S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 Glul ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a5 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI Ldhd GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Acat1 Acat2 Gcdh Echs1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Impa2 Ocrl Pten Impa1 Inpp5k Inpp1 Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5f Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk Bpnt2 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm1 Dut Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Dtymk Nme7 Nme6 Ntpcr Ctps2 Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Fads2 Acsl1 Acsm3 Acsbg1 Acsm4 Slc27a2 Acsm5 Acsbg2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Ggt5 Gstm4 Alox12 Gpx4 Alox5 Dpep1 Alox15 Ltc4s SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Ggps1 Acat1 Hmgcr Acat2 Mvd Hmgcs2 Fdps Idi1 Mvk Pmvk L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Gstz1 Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Tomt Aldh2 Aldh3a2 Adh4 Maoa Pnmt Comt Maob N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Gnpda1 Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Amdhd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Upb1 Dpys Dpyd SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Plcb2 Ip6k2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r4 Pip4k2a Pi4kb Inpp5d Pi4ka Itpka Plch2 Plch1 Inpp5a Plcd1 Plcd4 Synj1 Inpp5b Plcd3 Itpkc Itpk1 Itpkb Cdipt Ipmk Pik3cg Pik3cb Pik3cd Ocrl Pip4p2 Pip4p1 Pten Pik3ca Inpp5k Pi4k2b Plcz1 Pik3c2b Synj2 Inppl1 Plce1 Minpp1 Pik3c2a Pik3c2g Fig4 Pip5kl1 Mtmr3 Ppip5k1 Ppip5k2 Pip5k1c Pip5k1b Pip5k1a L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Aldh4a1 Prodh METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt2 Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss2 Acss1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 Paox L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Tgm1 Aloxe3 Slc27a4 Pnpla1 Cyp4f39 Alox12b Cers3 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis Carns1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Cad Umps Dhodh GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh Nt5c2 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Cat Sod3 Sod2 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Impa2 Impa1 Isyna1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Ndufa10 Cox7b Uqcrfs1 Ndufs1 Ndufs2 Ndufa13 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs8 Coxfa4l2 Uqcrq Coxfa4 Ndufa1 Ndufa3 Ndufa2 Ndufa5 Ndufa7 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cyc1 Ndufb2 Uqcrc2 Ndufb3 Uqcrc1 Ndufb6 Ndufb5 Ndufb8 mt-Nd4l Ndufb7 Ndufb9 Cox6b1 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcrb Uqcr10 mt-Co2 mt-Cytb mt-Co3 mt-Nd4 mt-Nd5 mt-Nd6 Ndufab1 Ndufc1 Ndufc2 mt-Co1 Sdhd Sdhc Sdhb mt-Nd1 Sdha mt-Nd2 mt-Nd3 Ndufa12 Cox6a1 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Nus1 Srd5a3 Dolk Dhrsx Dhdds PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Pfas Ak8 Atic Ppat Paics Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Adsl Impdh1 Guk1 Gart Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 Adss1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk2 Nmrk1 Nmnat3 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glul Glud1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pdx Pgls Pgd UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Coq6 Coq7 Pdss2 Pdss1 Coq2 Ubiad1 Coq3 Coq4 Coq5 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Impdh1 Nme4 Guk1 Nme1 Gmps Nme7 Nme6 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Vps29 Shmt2 Psat1 Shmt1 Phgdh Psph PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Nme3 Nme2 Nme5 Nme4 Guk1 Nme1 Nme7 Nme6 Ak5 Dguok Dck THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Dio1 Dio2 Ugt1a9 Sult1a1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Asns Gls2 Gls VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Nqo1 Ggcx Vkorc1l1 Vkorc1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Cyp1a2 Sult1a1 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Pnp Ada GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Gstz1 Gsta5 Gsta3 Anpep Gstm7 Gstm5 Ggt5 Gstk1 Gstm1 Nat8 Gstm2 Gsto2 Mgst3 Gstt2 Mgst2 Gstt1 Mgst1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Gart ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Alox5 Lta4h Ptgs2 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Azin2 Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Pcyt2 Cept1 Etnk1 Chkb Selenoi CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis Carns1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Tm7sf2 Hsd17b7 Sqle Nsdhl Ebp Lbr Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Dtymk Nme7 Nme6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Alox12 Gpx4 Alox15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Crym Aadat Pycr1 Pipox Dhtkd1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal5 Hyal4 Hyal1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp6v0b ATP6 Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp5pf Atp6v1c1 Atpaf2 Atp6v1a Atp6v1b2 Atp6v0d1 Vps9d1 Atp5mc3 Atp5mf Atp5me Atp6v0e1 Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Fpgs Shmt2 Shmt1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Vps29 Psat1 Phgdh Psph L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Pfas Ppat Gart PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Ggps1 Hmgcr Mvd Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Sqle Ebp Lbr Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Acat1 Acat2 Fdps Idi1 Mvk Pmvk PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Bdh1 Acat1 Hmgcs2 Hmgcl Bdh2 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Dcxr Cryl1 Akr1a1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pi4k2b Plcz1 Plce1 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Plcb4 Plcb3 Plcb2 Plcb1 Pi4k2a Plcg1 Plcg2 Pip4k2b Pip4k2c Pip4k2a Pi4kb Pi4ka Plch2 Plch1 Plcd1 Plcd4 Plcd3 Cdipt ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Aldh2 Aldh3a2 Acss2 Acss1 Cat CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Acat1 Acat2 Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Acadsb Echs1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Fads1 Fads2 Elovl7 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B3galt1 B3gnt5 B3gnt2 Fut2 Fut1 A4galt B4galt4 B4galt6 B4galnt1 Gbgt1 St3gal6 St3gal4 St3gal5 St3gal2 B4galt1 B4galt2 B4galt3 B3galnt1 St6gal1 B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B4galt2 B4galt3 St6gal1 St8sia2 St8sia3 Ugcg B3gnt5 B3gnt2 B4galt4 B4galt6 St3gal6 St3gal4 B4galt1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fpgt Fcsk GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Upb1 Dpys Dpyd S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation Mtap NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt Nadk CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Chdh Aldh7a1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Peds1 Agpat1 Pcyt2 Cept1 Etnk1 Chkb Selenoi Gnpat Pcyt1b Pcyt1a Agps Far2 Far1 Chka L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Afmid Haao Got2 Aldh8a1 Kyat3 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Dhtkd1 Aadat Kyat1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Hsd17b7 Cyp2a5 Cyp19a1 Hsd17b11 Hsd17b3 Hsd17b1 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 Elovl7 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St6gal1 B3galt4 B4galt6 Ugcg B4galnt1 St8sia1 St3gal5 St3gal2 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt1 Abo B3galt5 Fut2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Akr1b10 Cyp2e1 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat2b Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Dhodh Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ippk Itpk1 Ipmk GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Acot2 Scd1 Acot3 Acot4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Tbxas1 Hpgds Hpgd Akr1c18 Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 Cbr1 Ptgs2 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Pip4p2 Ocrl Pip4p1 Pten Inpp5k Synj2 Sacm1l Inppl1 Inpp5e Inpp4a Mtmr14 Mtmr3 Inpp4b Tpte Inpp5d Inpp5f Synj1 Inpp5b ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Tecr Hsd17b12 Elovl4 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcs Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Ephx3 Alox12 Gpx4 Alox5 Alox15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Tbxas1 Hpgds Hpgd Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 Ggt5 Ephx3 Alox8 Gstm4 Alox12 Dpep2 Cyp4f15 Gpx4 Alox5 Cyp2j6 Dpep1 Cyp4f3 Alox15 Cyp2d22 Ltc4s Lta4h Ptgs2 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi6 Padi2 Padi3 Padi4 Padi1 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Ocrl Pten Inpp5k Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k1 Ip6k2 Ip6k3 Ippk Ppip5k1 Ipmk Ppip5k2 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio1 Dio3 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd1 Txnrd3 Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Alox5 Ptgs2 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Bdh1 Acat1 Oxct1 Bdh2 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Dera Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox12 Alox5 Alox15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Maoa Cyp2c50 Cyp1a2 Sult1a1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Aldh8a1 Acmsd Dhtkd1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx3 Gsr Gpx7 Gpx4 Gpx2 Gpx1 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nampt Nmnat1 Nmnat3 Nmnat2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Abhd5 Mboat2 Agpat1 Agpat3 Lclat1 Agpat4 Agpat2 Cds2 Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam Mboat1 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm Minpp1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Aldh3a2 Fa2h Hacl1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Bpgm Gpi Tpi1 Pcx Mdh1 Mdh2 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc2 G6pc3 EG433182 Pgk1 Pgam2 Pgam1 Pgk2 Fbp1 Pck1 Fbp2 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Aoc2 Aldh2 Aldh3a2 Aoc3 Maoa Maob PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Tecr Elovl1 Hsd17b12 Elovl7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Fads1 Fads2 Acsl1 Elovl5 Acsm3 Hsd17b12 Acsbg1 Acsm4 Slc27a2 Acsm5 Elovl7 Acsbg2 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Itpk1 Ipmk &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Ggt5 Gclc Gss Cndp2 Gclm Oplah UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ntpcr Ctps2 Ctps1 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Pygm Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Pygb Mgam Hkdc1 Pygl L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Hibch Acad8 Bckdhb Hibadh Bckdha Aldh6a1 Dbt Bcat1 Dld Abat Bcat2 Echs1 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Ntan1 Ate1 Naa20 Naa25 Ntaq1 Metap1 Apeh Metap2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Alox5 Ptgs2 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1l1 Got1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Hkdc1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II Maoa TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Tsen34 Rtcb Tsen15 Ddx1 AI597479 Rtraf Tsen54 Fam98b Zbtb8os Tsen2 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tk2 Tk1 Dck Tyms PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Rrm1 Dut Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Dtymk Nme7 Nme6 Ntpcr L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Pycr2 Pycr1 Aldh18a1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gsta3 Gsta5 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Nt5c1a Nt5e Nt5c3a Impdh1 Pnp Gda Xdh Nt5c2 Ada L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Ahcy Mat2a Mat2b Mat1a Cbs Cth L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Mtap Mat2a Srm Mat2b Mat1a Enoph1 Adi1 Kyat1 Mri1 Apip D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Impa2 Ocrl Impa1 Inpp5k Inpp1 Synj2 Inppl1 Inpp5f Inpp5a Synj1 Inpp5b Bpnt2 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Bmpr2 Bmp2 Smad4 Acvr2a Bmpr1b Zfyve16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Ggt5 Gstm4 Dpep2 Alox5 Dpep1 Ltc4s Lta4h PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b6 Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Xdh Rbp4 Rbp1 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclc Gss Gclm DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Aldh3a2 Maoa Comt Maob MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Ephx3 Alox12 Alox15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1l1 Got1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis Gal3st1 Ugt8 St3gal5 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldha Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Aldh2 Aldh3a2 Aldh1b1 Aldh3b1 Aldh3a1 Maoa Sat2 Sat1 Maob CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckmt2 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Hmgcll1 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Mccc1 Auh Hmgcl Ivd Mccc2 GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Got1 Aga Aspg Asrgl1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Aldh2 Aldh3a2 Maoa Sult1a1 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Ak8 Adsl Ak1 Ak3 Ak2 Ak5 Adss2 Ak7 Adss1 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat3 Plaat1 Plaat5 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Afmid Haao Kmo Tdo2 Kynu Ido2 Ido1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Plcz1 Plce1 Plaat3 Plaat1 Plaat5 Pla2g2e Pla2g4f Pla2g2d Plcb4 Pla2g2f Plcb3 Pla2g4c Pla2g4e Pla2g4d Pld4 Pla2g4a Plcb2 Pld1 Plb1 Plcb1 Pld3 Pld2 Pla2g12a Pnpla8 Pla2g5 Plcg1 Pla2g3 Plcg2 Pla2g6 Pla2g1b Oc90 Pla2g10 Plch2 Plch1 Plcd1 Plcd4 Plcd3 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Tm7sf2 Hsd17b7 Sqle Nsdhl Ebp Lbr Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Got1 Gclc Gss Gclm COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Ppcs Pank3 Ppcdc Pank2 Coasy Pank1 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Aldob Aldoc Tkfc Aldoa Sis Khk Tpi1 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1 Prps2 Prps1l1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Tk2 Tk1 Tyms Nme3 Nme2 Nme5 Nme4 Cda Cmpk2 Nme1 Cmpk1 Dtymk Nme7 Nme6 Dck PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Cept1 Chkb Pcyt1b Pcyt1a Chpt1 Chka SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Afmid Haao Akr1a1 Nmnat1 Aldh8a1 Kmo Tdo2 Nmnat3 Nmnat2 Kynu Ido2 Acmsd Maoa Ido1 Dhtkd1 Maob Aldh2 Sult1a1 Aanat Tph2 Ddc Tph1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Cyp1a2 Gcdh Echs1 Acat1 Acat2 Aldh3a2 Qprt Nadsyn1 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Scp2 Hsd17b4 Acaa1a Hadh Hsd17b10 Acsbg1 Ehhadh Slc27a2 Acox1 Echs1 Acox2 Acsbg2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Ddc Akr1a1 Aldh3a2 Maob TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Lars2 Gars1 Qars1 Lars1 Vars1 Farsa Farsb Cars2 Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Iars2 Tars1 Ears2 Hars1 Pars2 Mars1 Mars2 Dars2 Yars2 Yars1 Hars2 Dars1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage Pdxk Pnpo N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Gnpda1 Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Ak8 Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Pnp Aprt Hprt1 Ada Adsl Impdh1 Guk1 Adk Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 Adss1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Lass1 Sptlc1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Rrm1 Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Dctd Nme1 Dtymk Nme7 Nme6 Ntpcr UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 Ctps2 Ctps1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Dmgdh Chdh Aldh7a1 Shmt2 Shmt1 Bhmt TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Aco2 Sucla2 Dld Mdh1 Mdh2 Fh Sdhd Idh3a Sdhc Dlst Sdhb Idh3b Sdha Cs Idh3g Suclg1 Suclg2 Ogdh N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 Tsr3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Scp2 Hadh Hadha Hsd17b10 Hadhb Acaa2 Eci1 Acsbg1 Slc27a2 Echs1 Acsbg2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Lass1 Sptlc1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Sord Adh1 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis B3galt1 B3gnt5 St6gal1 B3galt5 Fut2 B4galt6 Ugcg St3gal5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd2 Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Afmid Haao Aldh8a1 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Gcdh Dhtkd1 Echs1 Acat1 Acat2 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Ogt Oga CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Aldh1a2 Rdh16f2 Aldh1a1 Aldh1a3 Sdr16c5 Rbp4 Rbp1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide B4galt2 B4galt3 Abo Fut1 St8sia2 Fut9 Chst1 St3gal4 B4galt1 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Cda Upb1 Upp1 Dpys Upp2 Dpyd THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio1 Dio3 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4galt2 B4galt3 B3gnt2 Gcnt3 Gcnt2 B4galt1 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pfkp Bpgm Gpi Tpi1 Hk3 Hkdc1 Gapdhs Aldob Aldoc Hk2 Eno3 Gck Eno2 Hk1 Aldoa EG433182 Pgk1 Pgam2 Pgam1 Pklr Pgk2 Pfkl Pkm Pfkm HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4galt2 Lalba St6galnac6 St6gal1 B3gnt2 B3galt5 Fut2 B4galt4 Gcnt3 B4galt1 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Nt5e Impdh1 Pnp Xdh Nt5c2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Tyr Dct Trpc1 Tyrp1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Acsf3 Mcat Ndufab1 Oxsm ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation Faah FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd Adh5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galnt1 B3galt5 Fut2 Fut1 A4galt B4galt6 Ugcg Gbgt1 St3gal2 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Hk2 Gck Hk1 Treh Hk3 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Ephx3 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rbp2 Rbp3 Rdh5 Dhrs9 Lrat Rlbp1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 Rpe65 Rbp1 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Srd5a1 Srd5a2 Akr1c18 Cyp17a1 Hsd3b6 Hsd3b1 Hsd17b3 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Nme3 Nme2 Nme5 Impdh1 Nme4 Guk1 Nme1 Gmps Nme7 Nme6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 Rbp1 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Ephx3 Alox12 Gpx4 Alox5 Cyp2d22 Alox15 Ptgs2 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3cd Pik3ca Pi4k2b Pik3c2b Pik3c2a Pik3c2g Fig4 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Pikfyve Pik3c3 Sacm1l Pi4k2a Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pik3r2 Pik3r4 Pi4kb Pi4ka Cdipt Pik3cg Pik3cb UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Uap1 Pgm3 Hk2 Gnpda1 Gck Hk1 Gnpda2 Gpi Hk3 Gale Hkdc1 Gnpnat1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis Hkdc1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Got1 Cdo1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Elovl6 Acot7 Acsl1 Hsd17b12 Acsbg1 Acot2 Slc27a2 Acot3 Acot4 Elovl7 Acsbg2 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Aldh4a1 Got2 Hoga1 Prodh2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f15 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Acsl1 Ptgr1 Acsbg1 Slc27a2 Acsbg2 Acer1 Acer2 Asah2 Asah1 Sphk2 Sphk1 Sgpp2 Sgpp1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Pnp Pgm2 Ada PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Cda Upp1 Upp2 Tymp D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Pip4p2 Pip4p1 Plcb2 Plcz1 Plcb1 Plce1 Plcg1 Plcg2 Mtmr14 Mtmr3 Pip4k2c Pip4k2a Plch2 Plch1 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Srd5a1 Akr1c6 Srd5a2 Akr1c18 Akr1c21 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Mthfd2l Aldh1l1 Mthfsl Aldh1l2 Mthfd2 Mthfr Shmt2 Shmt1 Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat2b Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Pnp Hprt1 Ada REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Gpx3 Gpx7 Gpx6 Cat Gpx5 Gpx8 Sod3 Gpx2 Sod2 Gpx1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Nt5c1a Nt5e Nt5c3a Pnp Xdh Nt5c2 Ada ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Akr1b10 Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Aldh9a1 Shmt1 Tmlhe Bbox1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Ocrl Inpp5k Synj2 Inppl1 Ippk Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpk1 Itpkb Ipmk LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Alox8 Alox12 Gpx4 Alox5 Alox15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Daglb Cel Pnliprp2 Pnlip Lipc Pnpla2 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Nanp Nans Cmas Gne CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Ptpmt1 Crls1 Pgs1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Nmnat3 Nmnat2 Qprt Nadsyn1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis Cox10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Fads2 Elovl2 Elovl5 Hsd17b12 Elovl7 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4galt2 B4galt3 St6gal1 B3gnt2 St8sia2 Gcnt3 Gcnt2 St3gal4 B4galt1 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Aldh2 Aldh3a2 Cyp2e1 Acss2 Acss1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Aldh2 Aldh3a2 Acss2 Acss1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Mcee Dld Pcca Pccb Mmut LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1l3 Glb1 Lct NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Fmo3 Fmo2 Fmo5 Fmo4 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 Ugt1a5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Pgm1 Galt Galm Galk1 Pgm2 Gale UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Uap1 Pgm3 Hk2 Gck Hk1 Gfpt1 Gpi Gfpt2 Hk3 Hkdc1 Gnpnat1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt2 Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Atic Adsl Paics L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Aadat Aldh7a1 Aass Dhtkd1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sars2 Sars1 Pstk Sephs2 Sephs1 Sepsecs FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Phyh Acsm1 Aldh3a2 Hacl1 Slc27a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis Glul TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Ggps1 Fdps THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Tyw1 Lcmt2 Tyw3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Napepld Gde1 Plaat1 Enpp2 Plaat5 Pla2g1b VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Acat1 Acsm1 Acat2 Acadsb Echs1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Afmid Haao Nmnat1 Kmo Tdo2 Nmnat3 Kynu Nmnat2 Ido2 Qprt Ido1 Nadsyn1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsl3 Acsl1 Acsbg1 Slc27a2 Acsbg2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Dagla Plcb1 Daglb Ddhd1 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) Slc34a2 Aqp7 Slc2a1 Pnp Hemk2 Slc20a2 Slc20a1 Trmt112 Aqp9 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp2b10 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation Adh5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm1 Ugp2 Pgm2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Alox5 Lta4h Ptgs2 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 Papss1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Gmppb Gpi Pmm1 Mpi CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Tm7sf2 Hsd17b7 Sqle Nsdhl Ebp Lbr Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss UREA CYCLE%BIOCYC%PWY-4984 urea cycle Asl Cps1 Ass1 Otc GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Dmgdh Shmt2 Shmt1 Bhmt SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Suox Tst Sqor HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Alad Alas1 Alas2 Hmbs Fech Cpox Uros Urod Ppox PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Mcee Pcca Pccb Mmut L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Sds Bckdhb Bckdha Dbt Sdsl Dld GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Pnp Hprt1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Nos3 Nos2 Nos1 Asl Ass1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Got1 Bckdhb Bckdha Dbt Cbs Mcee Cth Dld Bhmt Pcca Bhmt2 Pccb Mtr Mmut Suox Cdo1 Ahcy Mat2a Mat2b Mat1a TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas1 Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Acat1 Hmgcr Acat2 Mvd Hmgcs2 Idi1 Mvk Pmvk TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Ppcs Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Agpat1 Plpp4 Plpp2 Plpp3 Plpp1 Mogat1 Dgat2 Plppr4 Dgat1 Plppr2 Plppr3 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam Mboat1 Abhd5 Mboat2 Agpat3 Lclat1 Agpat4 Agpat2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis Flad1 Rfk D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Minpp1 Itpk1 Ipmk CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh Pnmt 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw1 Tyw3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Cdo1 Fmo1 Csad ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Got1 Mdh1 Mdh2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor Bcar1 Fzr1 Ncoa1 Ap2b1 Arrb2 Fosb Cd44 Runx2 Kat2b Rb1 Mapk14 Tgfbr3 Prkar2a Pml Ski Map2k3 Mef2a Mef2c Brca1 Zfyve9 Rock1 E2f4 Tgfbr1 Cdkn1a E2f5 Tgfbr2 Atf2 Mapk8 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Ctnnb1 Map3k7 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Myc Cdc27 Akt1 Sox9 Cdc23 Skp1 Pdk1 Pard6a Dcp1a Rbx1 Prkcg Eid2 Prkcb Hgs Ube2d3 Prkcd Ube2d1 Nup153 Trp73 Btrc Cdc25a Atf3 Jund Sdc2 Pxn Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Ar Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Vdr Trp53 Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Ptk2 Stk11 Hspa8 Crebbp Smad2 Map4k1 Nup214 Smad3 Wwtr1 Sparc Smad4 Cdk6 Fnta Cdk4 Cdk2 Cul1 Cdc16 Cdk1 Tab1 Junb Daxx Smad6 Smad7 Hnf4a Rhoa Tgif1 Ing2 Xpo1 Xpo4 Ctcf Hdac1 Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Rbl2 Zeb2 Rbl1 Anapc10 Foxh1 Smurf2 Smurf1 Skil Pik3r1 Crk Pik3r2 Eng Lef1 Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Nfyc Prkar1b Ep300 Strap Map2k6 BDNF%IOB%BDNF BDNF Ptk2b Irs2 Elk1 Gsk3b Ntrk2 Ntrk1 Mapk3 Raf1 Akt1 Mapk9 Mapk8 Shc4 Mapk7 Shc1 Irs1 Mapk1 Foxo3 Plcg1 CCR1%IOB%CCR1 CCR1 Pxn Ptk2b Mapk3 Ccr1 Zap70 Creb3 Mapk14 Src Gna14 Rela Ccl7 Ccl5 Ccl4 Ccl3 Nfkb1 Stat1 Prkcd Ptk2 Mapk1 LEPTIN%IOB%LEPTIN Leptin Stat3 Grb2 Lepr Mapk3 Mapk14 Prkcd Irs1 Irs2 Sp1 Pik3r1 Pik3r2 Pde3a Itgav Socs7 Ncoa3 Ptpn11 Slc2a4 Jak3 Jak2 Egfr Ptk2 Khdrbs1 Itgb5 Mapk1 Lep Prkce THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin Stat3 Map2k1 Stat5b Atxn2l Mpl Mapk3 Gab1 Jak2 Shc1 Mapk1 Foxo3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor Akt1 Mapk14 Prkcb Shc1 Plcg1 Gsk3b Raf1 Src Rela Stat1 Jun Ptpn11 Jak3 Jak2 Grb2 Stat5b Socs1 Mitf Socs5 Socs4 Matk Socs6 Crkl Ptpru Gys1 Cltc Sh3kbp1 Cblb Mad2l1 Fgr Hck Dok1 Wipf1 Rps6ka1 Tnfrsf10b Kit Prkca Spred1 Il7r Sos1 Spred2 Inpp5d Grb7 Rasa1 Was Eif4ebp1 Cbl Mtor Epor Csf2rb2 Abl1 Fyn Grap Lyn Kitlg Pik3r1 Yes1 Crk Pik3ca Pik3r2 Stat5a Tec Fes Hras Atf2 Mapk8 Ep300 Mapk1 CCR7%IOB%CCR7 CCR7 Ptk2b Foxo1 Gsk3b Mapk3 Mtor Mapk14 Akt1 Rela Cfl1 Ccr7 Adrb2 Mapk8 Mapk1 Foxo3 Plcg1 WNT%IOB%WNT Wnt Ctnnb1 Pi4k2a Map3k7 Rac1 Ppp1ca Nfatc2 Sfrp2 Arrb2 Ppp2ca Sfrp1 Daam1 Rspo1 Prkaca Akt1 Dkk1 Mesd Pax2 Gsk3a Frzb Dixdc1 Chd7 Axin1 Prkcg Ror1 Ror2 Prkcb Gckr Lrp1 Arhgef4 Prkcd Lrp6 Csnk1a1 Nlk Lrp5 Wnt3a Dvl1 Dvl2 Gpc3 Dvl3 Wnt7a Wnt2 Wnt1 Gsk3b Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd3 Fzd5 Jup Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Fzd8 Smad1 Bcl9 Apc Jun Pin1 Tcf4 Pip5k1b Ccnd1 Cdk6 Rhoa Prkca Yes1 Lef1 Ilk Mark2 Mapk8 Sox1 Wnt5a Ctbp1 Cdh1 Setdb1 Ywhab FAS%IOB%FAS Fas Fas Rac1 Pkn2 Pkn1 Vim Dffa Cdk11b Mapk3 Cdc27 Akt1 Rock1 Prkcd Csnk1a1 Gsk3b Traf3 Psme3 Faf1 Eif2ak2 Arhgdib Stk24 Map3k5 Xpo5 Parp1 Traf2 Traf1 Dedd2 Plec Csnk2b Map2k1 Prkn Parg Rfc1 Mst1 Bcl2l1 Xiap Glrx Casp8ap2 Eif3j2 Eif4b Gtf3c3 Lck Tcp1 Daxx Btk Anxa4 Fadd Top1 Met Csnk1e Cast Dedd Cd59b Max Srf Aifm1 Uso1 Ptpn6 Uba7 Stk4 Stk3 Prkdc Rasa1 Ripk2 Fasl Numa1 Hspb1 Cflar Eif2s1 Bid Pak2 Fyn Casp8 Casp7 Lyn Tial1 Mbd4 Tia1 Casp9 Casp4 Casp3 Casp6 Fastk Satb1 Casp2 Casp1 Ripk1 Bmx Map2k2 Wee1 Diablo Pdcd6 Mapk1 Bax Bcl2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Rac1 Vim Erbb2 Clca1 Rpsa Ywhah Ywhae Akt1 Erbin Dsp Eif4e Lama5 Cd151 Itgb4 Lama2 Lama3 Mst1r Mylk3 Ywhaz Col17a1 Prkcd Itga6 Ntn1 Ephb2 Trp73 Pak1 Lamb2 Lamb3 Shc1 Pik3cg Irs1 Sfn Lamb1 Pik3cb Irs2 Pik3cd Rtkn Bad Eif6 Lamc1 Lamc2 Ar Src Ptpn11 Egfr Ptk2 Smad2 Grb2 Plec Smad3 Rhoa Met Prkca Eif4ebp1 Mtor Abl1 Fyn Pik3r1 Yes1 Pik3ca Pik3r2 Casp3 Ywhab NGF%IOB%NGF NGF Elk1 Map2k1 Mapk3 Creb1 Dnaja3 Prkci Frs2 Mapk1 Sp1 HEDGEHOG%IOB%HEDGEHOG Hedgehog Ctnnb1 Gas1 Kif27 Arrb2 Prkaca Ywhae Med23 Dhh Ihh Gli1 Gli3 Gli2 Shh Grk2 Ptch2 Ptch1 Dyrk1a Boc Med12 Med1 Hhip Stk36 Med6 Cdk8 Smo Sap18b Sufu GM-CSF%IOB%GM-CSF GM-CSF Bcar1 Mapk3 Akt1 Mapk14 Tgfbr3 Gsk3a Map2k3 Mapk9 Shc1 Plcg1 Pxn Elk1 Gsk3b Bad Raf1 Creb1 Tgfb1 Stat1 Jak2 Stat3 Grb2 Ikbkb Pdia3 Map2k1 Csf2ra Stat5b Slc2a1 Prdx3 Stam2 Gab1 Syk Rack1 Vav1 Sptan1 Rps6ka2 Ezr Crkl Pfn1 Csf2 Ganab Stam Cct5 Dpysl2 Ptprc Sh2b2 Hck Nfkbia Bcl3 Hnrnph1 Park7 Chuk Prkca Ptpn6 Cbl Csf2rb2 Lyn Pik3r1 Yes1 Pik3r2 Stat5a Fes Mapk8 Map2k2 Mapk1 Map2k6 CCR9%IOB%CCR9 CCR9 Ccl25 Foxo1 Itga4 Ccr9 Gsk3b Mapk3 Mapk14 Akt1 Ezr Mapk8 Rdx Madcam1 Msn Cdh1 Mapk1 Cd226 Itgb7 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK Grb7 Elk1 Nos3 Map2k1 Tie1 Stat5b Dok2 Mapk3 Tek Raf1 Nck1 Mapk14 Akt1 Stat5a Fes Bmx Pak1 Map2k2 Ptk2 Shc1 Mapk1 CCR5%IOB%CCR5 CCR5 Stat3 Grb2 Ikbkb Mapk3 Syk Akt1 Mapk14 Nfkbia Chuk Ptpn6 Ptk2b Psma5 C5ar1 Afp Ccl11 Cd4 Rela Ccl12 Ccl7 Ccl5 Ccl2 Ccl4 Ccr5 Pik3r1 Stat5a Stat1 Cfl1 Mapk1 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha Stat3 Stat5b Akt1 Vav1 Eif4b Crkl Map2k3 Nfkbia Prkcd Irs1 Foxo1 Irs2 Eif4ebp1 Cbl Mtor Zap70 Stat6 Crk Stat4 Stat5a Erbb3 Stat1 Pla2g4a Ifnar1 Ifnar2 Jak1 Arhgap30 Tyk2 Prkcq Map2k4 Rps6ka5 Stat2 Map2k6 TRAIL%IOB%TRAIL TRAIL Bex3 Ctnnb1 Chek2 Map3k7 Ikbkg Tnfrsf11b Prkaa1 Tradd Mapk3 Bak1 Bcl10 Mcl1 Xiap Vdac1 Akt1 Mapk14 Tnfsf10 Apaf1 Irf5 Atm Fadd Nfkbia Tnfrsf10b Aifm1 Prkdc Cbl Cflar Creb1 Bid Src Casp8 Casp7 Rela Nfkb1 Casp3 Casp2 Casp1 Ripk1 Diablo Ctsb H2ax Mapk1 Parp1 Bax Dap3 Traf2 NOTCH%IOB%NOTCH Notch Mapk3 Kat2b Skp1 App Sin3a Fhl1 Hivep3 Rbx1 Hdac2 Mfng Hey1 Numb Ccn3 Skp2 Sap30 Hes6 Tle1 Maml3 Notch4 Fbxw7 Notch1 Notch2 Notch3 Psen1 Pofut1 Gsk3b Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Dll1 Dll3 Rela Dll4 Itch Maml1 Ring1 Maml2 Smad1 Nfkb1 Hes1 Furin Jag2 Jag1 Cirsr Rbpj Yy1 Lfng Tcf3 Jak2 Stat3 Smad3 Smad4 Cul1 Hdac1 Lef1 Ep300 Mapk1 M-CSF%IOB%M-CSF M-CSF Gab3 Stat3 Pstpip2 Grb2 Dnm1 Csf1 Vim Stat5b Mitf Akt1 Fadd Prkcd Shc1 Ptk2b Inpp5d Cbl Casp8 Pik3r1 Stat5a Ptpn11 Ripk1 Ets2 Csf1r Myo18a Ptk2 Inppl1 Grap2 Tfe3 EGFR1%IOB%EGFR1 EGFR1 Mapk8 Mapk1 Mapk3 Myc Akt1 Prkcg Prkcb Hgs Prkcd Jund Pxn Dab2 Sp1 Jun Trp53 Cav1 Ptk2 Stk11 Smad2 Smad3 Cdk2 Cdk1 Rhoa Tgif1 Hdac1 Zfyve16 Foxo1 Fos Pik3r1 Crk Pik3r2 Bcar1 Ap2b1 Mapk14 Map2k3 Mapk9 Mapk7 Shc1 Plcg1 Ptk2b Irs2 Elk1 Gsk3b Raf1 Src Rela Nfkb1 Stat1 Ptpn11 Jak2 Egfr Khdrbs1 Stat3 Grb2 Map2k1 Stat5b Gab1 Socs1 Crkl Cltc Sh3kbp1 Cblb Dok1 Rps6ka1 Kit Prkca Sos1 Grb7 Rasa1 Eif4ebp1 Cbl Mtor Abl1 Fyn Lyn Pik3ca Stat5a Hras Cfl1 Ctbp1 Cdh1 Ywhab Rac1 Gsk3a Arhgef4 Jup Plec Lck Anxa4 Met Cd59b Ptpn6 Casp9 Ripk1 Map2k2 Bcl2 Pkn2 Vim Erbb2 Erbin Dsp Itgb4 Ywhaz Col17a1 Ephb2 Pak1 Pik3cg Pik3cb Pik3cd Bad Creb1 Prkci Frs2 Grk2 Dyrk1a Stam2 Vav1 Rps6ka2 Pfn1 Stam Nos3 Dok2 Nck1 Erbb3 Jak1 Tyk2 Rps6ka5 Stat2 Prkaa1 App Itch Inppl1 Dnm1 Myl12b Il17rd Pard3 Mprip Prkd1 Elk4 Eps8 Gja1 Tfg Ralb Otud6b Araf Plcg2 Arhgap5 Itsn2 Arap1 S100a14 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot2 Flot1 Errfi1 Myo6 Scrib Prkcz Tfrc Garem1 Pik3c2b mt-Co2 Antxr1 Arf4 Braf Shb Clta Pgam1 Cyld Ldha Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl1 Appl2 EG433182 Caskin2 Stx4 Pygb Gsn Pdzd11 Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Abi1 Ensa Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Socs3 Atxn2 Grb14 Grb10 Phpt1 Stip1 Map3k4 Pias3 Cdh3 Cdh2 Plekhn1 Eps15 Map3k3 Magi1 Map3k2 Map3k1 Hat1 Pkp2 Hnrnpdl Ldlr Pkp4 Pkp3 Flnb Anxa2 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Abl2 Serpinb3d Slc38a2 Ptpre Tnk2 Ptpra Cdk5 Alb Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Acp1 Sh3gl3 Adam9 Epha1 Epha2 Epha4 Itgb1 Pkm Dsg2 Sh3gl2 Sos2 Ctnnal1 Ubash3b Wbp2 Atp1a1 Sri Ephb1 Cebpb Cebpa Ephb3 Ephb4 Ahcyl1 Hnrnpa1 Ptpn1 Slitrk6 Csk Arhgap32 Arhgap35 Rbbp7 Tagln2 Pten Sh2b1 Ralbp1 Bcar3 Slc25a5 Spart Nectin1 Rps10 Ppp2r3a Prkaa2 Scamp3 Tns4 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Rin1 Tln1 Vasp Arhgef7 H3c8 Hnrnpr Sdc4 Sdc3 Insr Atp5f1c Usp6nl Pttg1ip Slc5a5 Snx5 Tollip Ptk6 Pdcd6ip Kirrel1 Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Dyrk1b Ptprk Dcbld2 Ptprf Git1 Rps27l Vav3 Laptm4a Cdv3 Plekha6 Plekha5 Vav2 Mink1 Actn1 Prpf4b Actn4 Plscr1 Gprc5a Aldoa Map2k7 Map2k5 Limd1 Cstb Git2 Krt18 Krt17 Racgap1 Wasl Cttn Mpzl1 Axl Ctnnd1 Nedd9 Huwe1 Tjp2 Cavin1 Cavin2 Sdcbp Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Sirpa Ralgds Dlg3 Crim1 Ddx6 Peak1 Afap1l2 Ddx3x Sfpq Pdpk1 Dapp1 Iqgap1 Asap1 Anks1 Asap3 Baiap2 Lsr Epn2 Epn1 Dyrk4 Rps6ka3 Epn3 Dock4 Usp31 Dyrk3 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Ptpn18 Rgs16 Ptpn12 Mta2 Egf Spry2 Spry3 Spry1 Reps2 Prag1 Spry4 Pebp1 Ptpn23 Zpr1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor Trim68 Bag1 Gtf2h1 Ncoa1 Psmc3ip Rbak Ccnd3 Cdk11b Nelfcd Pelp1 Runx2 Cdk9 Kat2b Xrcc6 Rb1 Cdk7 Hspa5 Xrcc5 Mdm2 Fhl2 Pias3 Pou2f1 Prmt1 Rac3 Rnf14 Brca1 Calr Nr0b2 Spdef Etv5 Efcab6 Lpxn Svil Ddc Il6st Tmf1 Arnt Hsp90b1 Zmiz2 Zmiz1 Rnf4 Foxa1 Gsk3b Magea13 Ncoa2 Ncoa6 Nsd2 Nsd1 Pnrc1 Pak6 Src Stub1 Tgfb1i1 Rela Slc25a4 Vip Rchy1 Ran Ncoa3 Egfr Stat3 Cebpa Rack1 Pten Park7 Ccne1 Ctnnb1 Ppp1ca Akt1 Sin3a Cdc25a Pxn Ar Ncor2 Sp1 Jun Tcf4 Ccnd1 Cav1 Esr1 Hspa8 Parp1 Smad3 Smad4 Prkd1 Daxx Top1 Tgif1 Hdac1 Brinp1 Nr2c2 Hspb1 Nr2c1 Nrip1 Ahr Hsp90aa1 Uxt Casp8 Pias4 Casp7 Kat5 Ube2i Kat7 Pik3r1 Gtf2f2 Gtf2f1 Pias1 Casp3 Sf1 Appl1 Ccnh Prdx1 Tle5 Patz1 Casp1 Dapk3 Flna Gsn Cdc37 Pa2g4 Ranbp9 Senp1 Ep300 Cdc25b Nono FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 Stat3 Cebpa Cbl Mapk3 Creb1 Gab1 Akt1 Lyn Flt3 Gab2 Stat5a Jun Cblb Atf2 Mapk1 CD40%IOB%CD40 CD40 Stat3 Ikbkb Map2k1 Mapk3 Syk Myc Mapk14 Akt1 Fyn Lyn Lck Pik3r1 Plcg2 Jun Fgr Nfkbia Jak3 Mapk9 Mapk8 Chuk Mapk1 TNFSF3%IOB%TNFSF3 TNFSF3 Rela Nfkb1 Traf5 Jun Relb Tnfrsf1b Tnfrsf1a Traf3 Nfkbia Nfkb2 Lta Ltb Ltbr Traf2 ID%IOB%ID ID Id4 Id3 Elk1 Myf5 Smad3 Tcf7l2 Rbl2 Rb1 Elk4 Rbl1 Cdk2 Hes1 Tcf3 Myod1 Psmd4 Pax5 Elk3 Atf3 Id2 Id1 G-CSF%IOB%G-CSF G-CSF Stat3 Grb2 Il3ra Csf3r Stat5b Pom121 Mapk3 Fth1 Pla2g1b Socs3 Syk Syp Rel Akt1 Mapk14 Cdk2 Cish Cdkn1b Csf3 Lck Hck Csnk1e Rps6ka1 Shc1 Inpp5d Cbl Prkci Lyn Gab2 Stat5a Stat1 Jak1 Ptpn11 Tyk2 Jak2 Mapk1 EPO%IOB%EPO EPO Stat3 Map2k1 Stat5b Mapk3 Gab1 Syk Akt1 Vav1 H2bc7 Gsk3a Crkl Hcls1 Sgk1 Sh2b2 Foxo4 Foxo3 Foxo1 Irs2 Bad Nos3 Braf Raf1 Mtor Epor Stat5a Jun Ptpn11 Jak2 Map2k2 Rps6ka5 Mapk1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma Stat3 Cebpb Mapk3 Akt1 Mapk14 Crkl Spi1 Plcg2 Ifngr1 Hoxa10 Irf1 Irf2 Irf8 Mapk11 Cbl Raf1 Stat6 Crk Stat5a Stat1 Pla2g4a Jak1 Prkcq Mapk8 Jak2 Egfr Mapk1 TNFSF1%IOB%TNFSF1 TNFSF1 Ikbkg Akt1 Rela Nfkb1 Traf5 Jun Relb Tnfrsf1b Tnfrsf1a Traf3 Nfkbia Nfkb2 Tnfrsf14 Lta Ltbr TNFALPHA%IOB%TNFALPHA TNFalpha Pkn1 Map3k14 Cdk9 Ywhah Rb1 Ywhae Mapk14 Pml Map3k3 Ywhaz Map3k2 Map3k1 Mapk9 Creb1 Src Rela Nfkb1 Traf5 Stat1 Relb Tnfrsf1b Tnfrsf1a Nfkb2 Ptpn11 Egfr Ikbkb Gab1 Syk Rel Rack1 Nfkbia Dok1 Bcl3 Rpl4 Nkiras1 Nkiras2 Chuk Tbkbp1 Trib3 Map3k8 Nlrp4e Rps11 Tnf Fbl Unc5cl Tbk1 Tnfrsf11a Akt2 Dpf2 Kcnq1 Azi2 Polr1b Ppp1r13l Polr1c Polr1a Usp2 Polr1d Polr1e Fbxw11 Txlna Stat5a Tank Gtf2i Hsp90ab1 Actl6a Smarce1 Tifa Cdc34 Rasa3 Mark2 Mapk8 Nfkbiz Papola Rps6ka5 Glg1 Bag4 Mapk1 Sec16a Ripk3 Ywhab Cradd Map3k7 G3bp2 Dcaf7 Ikbkg Cops3 Nfkbib Nfkbie Tradd Mapk3 Kpna6 Kpna3 Ccnt1 Tab3 Akt1 Tab2 Traf7 Traf4 Skp1 Pfdn2 Traf6 Birc2 Tnfrsf8 Ikbke Ywhag Hdac2 Psmd12 Copb2 Map2k5 Smarcb1 Ube2d3 Psmd13 Prkcd Alpl Rasal2 Akap8 Hdac6 Btrc Iqgap2 Psmb5 Peg3 Fbxw7 Bcl7a Ppp6c Nupr1 Fkbp5 Smarca4 Mcm5 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Psmd7 Psmd6 Mapkapk2 Fancd2 Psmd3 Jun Psmd2 Cops5 Elp1 Psmd1 Traf3 Ktn1 Spag9 Cav1 Faf1 Usp11 Glb1 Smarcc2 Prc1 Ddx3x Smarcc1 Rnf25 Map3k11 Crebbp Traf2 Tnfaip3 Traf1 Lrpprc Mtif2 Cul1 Tab1 Fadd Hdac1 Prkcz Brinp1 Nr2c2 Hspb1 Cflar Bid Hsp90aa1 Casp8 Casp7 Ube2i Casp3 Casp2 Ripk1 Flna Cdc37 Map2k6 GDNF%IOB%GDNF GDNF Pxn Ptk2b Bcar1 Ret Map2k1 Th Cdc25c Raf1 Gab1 Rps6ka3 Fyn Cdk1 Crk Jun Met Nfkbia Dok1 Map2k2 Ptk2 TNFSF8%IOB%TNFSF8 TNFSF8 Traf1 Tnfrsf8 Nfkb1 Relb Traf3 Nfkb2 Bcl3 Rel Akt1 Rela Mapk1 CXCR4%IOB%CXCR4 CXCR4 Bcar1 Rac1 Arrb2 Mapk3 Vav2 Map2k3 Prkcd Plcg1 Pxn Ptk2b Elk1 Gsk3b Bad Creb1 Zap70 Src Rela Nfkb1 Stat1 Ptpn11 Jak3 Jak2 Egfr Ptk2 Hspa8 Stat3 Ikbkb Map2k1 Stat5b Itk Cxcr4 Itgb2 Icam1 Gnai1 Vav1 Tff2 Lcp2 Rps6ka2 Cxcl12 Gna13 Crkl Grk6 Lck Fyb1 Plcg2 Ackr3 Esr2 Vcam1 Cblb Limk1 Rhoa Ptprc Usp14 Nfkbia Dok1 Chuk Foxo3 Ptpn6 Inpp5d Rasa1 Was Cbl Nck1 Fyn Lyn Sdc4 Ccr5 Pik3r1 Crk Stat4 Pik3r2 Cfl1 Map2k2 Stat2 Mapk1 Ywhab CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 Il4 Cabin1 Pou2f1 Ifng Fasl Cd40lg Akap5 Nfatc1 Csf2 Junb Nfatc3 Ptgs2 Nfatc2 Rcan1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Jun Fos Atf2 Il10 Sin3a Sin3b Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Tgif2 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Tfdp1 Foxo3 Foxo1 Creb1 Sap30 Col1a2 Tfe3 Dcp1a Rbl1 Itgb5 Sap18b Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Ncor1 Dlx1 Nr3c1 Myod1 Max Ep300 Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Cited1 Sp3 Runx3 Runx2 Kat2b Kat2a Cbfb Vdr Rbbp4 Rbbp7 Esr1 Hspa8 Crebbp Ski Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 E2f4 Tcf3 Cdkn1a E2f5 Smad7 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Nfkbia Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il12b Il18 Il18rap Il19 Cd3e Tnf Mpo Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Cxcl3 Jak2 Il12rb1 Pik3ca Tyk2 Nos2 Il24 Il17f Il23a Rela Il17a SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Hdac1 Ranbp2 Hdac4 Ube2i Mdm2 Pias1 Ran Pias2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Jun Pik3r1 Fos Mapk8 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Cd44 Vav3 Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Itgb3 Rock2 Chuk Pip5k1a Map3k14 Nfkb1 Pik3ca Rela ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Fkbp1a Mapk1 Mapk3 Smad4 Smad7 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Ppp1ca Csnk2b Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 Eng SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Irs1 Src Jun Pxn Irs2 Grb10 Gdnf Ptpn11 Prkaca Pik3r1 Gfra1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Mapk8 Dok5 Mapk1 Dok6 Grb2 Prkca Mapk3 Sos1 Rhoa Crk Bcar1 Hras Rac1 Creb1 Pik3ca Ret Grb7 Shank3 Shc1 Rasa1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Prkaca Mapk1 Mapk3 Fgf15 Col11a1 Col11a2 Cask Ccl5 Bsg Hpse Ppib Col2a1 Mmp9 Sdcbp Col3a1 Mmp7 Col1a1 Col6a1 Col5a2 Col4a3 Tgfb1 Col4a4 Col7a1 Col6a2 Hgf Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Col1a2 Fgf23 Fgfr3 Fgfr4 Mmp1a Lama5 Sdc1 Met REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Plce1 Lgals1 Lgals3 Rasgrf1 Nras Prkcb Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Sos2 Grb2 Prkca Sos1 Hras Rasa2 Rasa4 Rabgef1 Camk2b Rasal1 Nf1 Dab2ip Kras Prkcz Rasa1 Syngap1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Incenp Aurkb IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Stat5a Pik3r1 Il4 Cd40lg Socs1 Spi1 Stat6 Alox15 Ets1 Socs5 Myb Jak3 Il10 Aicda Jak1 Il13ra1 Il13ra2 Arg1 Bcl2l1 Fcer2a Mybl1 Dok2 Irf4 Itgb3 Lta Oprm1 Tff3 Inpp5d Ptpn6 Akt1 Thy1 Ccl17 Cbl Mtor Selp Ccl11 Gtf3a Pigr Col1a2 Mapk14 Egr2 Parp14 Il2rg Stat5b Bcl6 Fes Il4ra Hmga1 Retnlg Shc1 Irs1 Irs2 Cebpb Il5 Sp1 Grb2 Col1a1 Socs3 Jak2 Pik3ca IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Lck Bcl2 E2f1 Ugcg Il2ra Ptpn11 Pik3r1 Il2 Grb2 Sos1 Myb Rac1 Jak3 Jak1 Bcl2l1 Myc Akt1 Mtor Foxo3 Il2rg Nfkb1 Pik3ca Smpd1 Il2rb Eif3a Hsp90aa1 Sgms1 Shc1 Prkcz Gab2 Rela Tert SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Nras Il2ra Stat1 Prkaca Pik3r1 Il2 Ifng Rhoa Jak3 Jak1 Il2rg Il2rb Gab2 Shc1 Irs1 Lck Bdnf Afdn Kdr Ptpn11 Angpt1 Lmo4 Ngf Gab1 Frs3 Frs2 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Ntf4 Grb2 Ntf3 Sos1 Pdgfrb Ifngr1 Vegfa Hras Pdgfb Pag1 Arhgap35 Nos3 Egf Igf1 Ntrk2 Map2k2 Ntrk1 Map2k1 Il6ra Ntrk3 Tek Igf1r Il6 Jak2 Pik3ca Kras NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Cdkn1b Ep300 E2f1 Ar Stat3 Ncoa1 Kdr Runx2 Myb Crebbp Tcf3 Ctbp1 Spen Neurog3 Hdac1 Ncor2 Arnt Ptf1a Camk2d Ghr Hif1a Maml1 Hey2 Maml2 Cd4 Hey1 Parp1 Hes1 Twist1 Ascl1 Rb1 Hes6 Jak2 Tle1 Gaa Rbbp8 Kdm1a Rbpj Yy1 Ncor1 Notch1 Gata6 Gata4 Rcan1 Myod1 Gata1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itga7 Itga8 Itgax Itga5 Itga6 Itga9 Itgam Itga4 Itga1 Itga2 Itgae Itgal Itga10 Itga11 Itgad Itgb8 Itgb6 Itgav Itgb7 Itgb1 Itga2b Itgb4 Itgb2 Itgb3 Itga3 Itgb5 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Incenp Rhoa Golga2 Nudc Bora Kif2a Kif20a Fbxo5 Spc24 Ercc6l Ppp1r12a Fzr1 Pak1 Ect2 Rock2 Tubg1 Bub1 Cdc14b Cdc20 Ppp1cb Ppp2ca Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Wee1 Ppp2r1a Prc1 Cdk1 Bub1b Btrc Ninl Kiz Cdc25c Aurka Cenpe Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Cstf1 Bard1 Fancl Prkdc Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad51 Rad50 Pcna Fancd2 Ewsr1 Trp53 Topbp1 Xrcc6 Brca1 Ube2d3 Xrcc5 Atm Ube2l3 Cdk2 Rbbp8 Ccne1 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Rhoa Gna12 Gnaz Gnao1 Gnai2 Gnai1 S1pr5 Gnai3 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Src Stat5a Nras Pik3r1 Ngf Gab1 Grb2 Sos1 Hras Camk4 Ywhah Ntrk1 Ywhag Ywhae Pdpk1 Camk2a Ywhab Trpc3 Trpv1 Agap2 Akt1 Sfn Egr1 Bad Ccnd1 Foxo3 Plcg1 Gsk3b Creb1 Prkcd Ywhaz Pik3ca Kras Shc1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Jun Il18r1 Stat3 Il2ra Fos Il2 Ifng Pias2 Mapk8 Crebbp Stat4 Tgfb1 Il18 Il18rap Cd3e Mapk9 Cd4 H2-Eb1 Il13 Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Tbx21 Etv5 Irf1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Kif2c Ppp2r5d Smc4 Smc2 Birc5 Evi5 Ncaph Ppp1cc Cbx5 Npm1 Cdca8 Racgap1 Ncapd2 Septin1 Incenp Tacc1 Mylk Aurkb Des Nsun2 Pebp1 Klhl13 Rhoa Cul3 Vim Kif23 Kif20a Bub1 Sgo1 Aurka Psma3 Cenpa Stmn1 Ndc80 Rasa1 Klhl9 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Src Pik3r1 Nck1 Ptk2 Mapk1 Mapk3 Rhoa Bcar1 Ntn1 Rac1 Dock1 Elmo1 Fyn Yes1 Trio Dcc Map2k2 Map1b Wasl Map2k1 Dapk1 Pak1 Unc5b Camk2a Myo10 Unc5a Unc5c Agap2 Plcg1 Pik3ca S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gna13 S1pr4 Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Rhoa Gna12 Gnaz Gnao1 Gnai2 S1pr5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Mapk1 Pde3b Pik3cg Pik3r6 Map2k1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Cdkn1b Nras Ube2i Spi1 Ets1 Ptgs2 Myb Sin3a Pias3 Myc Adora2b Ccna1 Slc25a3 Birc3 Prtn3 Map3k7 Col1a2 Ets2 Clta Tfec Pim1 Iqgap1 Cdkn2a Rag2 Ppid Gata3 Atp2b1 Pax5 Zfpm1 Snd1 Maf Ncor1 Ptcra Kit Smarca2 Myod1 Mcm4 Cd34 Ep300 Bcl2 Lef1 Mat2a Cebpb Trim28 Cebpd Nlk Cebpa Elane Sp1 Csf1r Gstm2 Yeats4 Copa Wnt1 H2az1 Ppp3ca Kitlg Cbx4 Casp6 Anpep Mad1l1 Hspa8 Ca1 Hras Crebbp Zfhx3 Ski Cdk6 Lect2 Myf6 Tab2 Tab1 Hipk2 Ada Cdkn1a Ccnd1 Mpo Cd4 Hes1 Kras Gata1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Src Pxn Nras Rras Pik3r1 Nck1 Rap1a Ptk2 Mapk1 Grb2 Mapk3 Crk Hras Rac1 Ephb1 Ephb2 Wasl Map2k1 Ephb3 Map4k4 Pak1 Ephb4 Tf Efnb1 Efnb2 Efnb3 Rap1b Synj1 Dnm1 Itsn1 Rock1 Kalrn Efna5 Pik3ca Grb7 Kras Shc1 Rasa1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Mapk10 Src Mapk11 Pik3r1 Fasl Mapk8 Syk Map3k1 Pdpk1 Chuk Akt1 Birc3 Ikbkb Mapk9 Birc2 Mapk14 Ikbkg Map2k7 Map2k6 Cltc Cflar Faim2 Pik3cb Bid Casp8 Pik3ca Smpd1 Rfc1 Casp3 Ripk1 Btk Fas Fadd Ezr PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Nfkbia Bcl2 Smpd3 Ctsd Aifm1 Eif2ak2 Pawr Nsmaf Madd Asah1 Tnfrsf1a Bag4 Raf1 Tradd Mapk8 Cradd Mapk1 Pdgfa Traf2 Prkra Mapk3 Ksr1 Eif2a Map2k4 Sphk2 Bax Egf Igf1 Map2k2 Map3k1 Map2k1 Map4k4 Myc Akt1 Bad Tnf Birc3 Prkcd Nfkb1 Rb1 Bid Casp8 Smpd1 Ripk1 Prkcz Rela Fadd ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Lck Src Ppp2r5d Fkbp1a Ube2l3 Blk Pld1 Plcb2 Fyn Klk6 Yes1 Syk Pld2 Grk5 Ptk2b Th Tor1a Sncaip Slc6a3 Lyn Prkn Uchl1 Maob Stub1 Fgr Hck Bad Park7 Snca Prkcd ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Nfkbia Lck Src Pik3r1 Arrb2 Bcl3 Rel Ikbkb Mapk14 Nfkb1 Btrc Pik3ca Syk Rela RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Pkn1 Cdkn1b Jun Sh3gl2 Tln1 Pip5k1c Pip5k1b Vcl F2rl2 Fos Scai Mapk8 Itgb1 Rhoa Map2k4 Atf2 Pld1 Pld2 Ppp1r12a Rock2 Pip5k1a Rock1 Srf Ccn1 Slc9a1 Acta1 Mapk12 Map2k6 Pard6a Diaph1 Slc9a3 Rdx Cfl1 Msn Pten Cit Map2k3 Myl2 Limk1 Limk2 Prkcz Mrtfa Pkn2 Ezr SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Stat5a Stat3 Pik3r1 Rhoa Itga2b Bcar1 Blk Fyn Yes1 Itgb3 Lyn Akt1 Fgr Hck Cav1 Stat5b Shc1 Irs1 Lck Src Ins2 Prl Csf1r Ybx1 Prlr Egfr Cdh2 Fcgr3 Dok1 Csn2 Csf1 Insr Trpv6 Grb2 Txn Ptpn1 Pdgfrb Crk Csk Capn1 Pdgfb Spry2 Fer Lep Nox4 Egf Lat Lepr Socs3 Jak2 Pik3ca Tyk2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Src Prkaca Itga2 Mapk8 Sdc2 Mapk1 Csf2 Mapk3 Itgb1 Rhoa Hras Fgf15 Bax Cask Fn1 Mmp2 Kng2 Tnfrsf13b Ephb2 Sdcbp Cav2 Trappc4 Rack1 Epb41 Lama1 Lama3 Tgfb1 Prkcd Fgf23 Fgfr3 Fgfr4 Casp3 Nf1 Rasa1 Ezr RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Nras Ptpn7 Prkcb Braf Fos Map3k8 Elk1 Raf1 Mapk1 Prkca Mapk3 Hras Kras Map2k1 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Jun Mapk11 Fos Pou2f1 Ifng Mapk8 Mapk1 Mapk3 Junb Cul3 Atf2 Arg1 Mmp2 Bcl2l1 Th Plau Creb1 Mapk14 Atf3 Ep300 Bcl2 Ins2 Cbfb Prkca Brca1 Esr1 Cdk4 Socs3 Hrk Ccna2 Ccnd1 Hbb-bh1 Serpinb5 Kat5 Ache Il6 Mapk9 Macroh2a1 Ddit3 Col24a1 Hes1 Jdp2 Ruvbl2 Csrp2 Rb1 Jund Gadd45a Sele Dusp5 Tgfb2 Dusp1 Nos2 Pdgfra Nf1 Dusp10 Il23a Dusp8 Ppargc1a EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Efna2 Lck Efna3 Src Arhgef15 Crkl Ngef Epha1 Epha2 Epha3 Vav2 Epha4 Epha5 Epha6 Epha7 Cdk5 Epha8 Rhoa Crk Blk Vav3 Fyn Yes1 Lyn Fgr Pik3cg Hck Cbl Pik3r6 Plcg1 Rock1 Efna5 Efna1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Nfkbia Stat3 Prkaca Ranbp2 Hdac4 Ube2i Tnfrsf1a Ran Nr2c1 Smg5 Prmt5 Hdac3 Hdac5 Hdac7 Hdac6 Hdac9 Hdac8 Fkbp3 Sin3a Pparg Sin3b Chd3 Chd4 Sirt3 Sirt2 Sirt1 Hdac2 Smurf1 Wdr77 Sirt7 Gata2 Sirt6 Sirt5 Hdac1 Sirt4 Hdac11 Hdac10 Mta2 Tfcp2 Mbd3 Mbd2 Gatad2a Mxd1 Sap30 Gatad2b Sap18b Btrc Zfpm1 Ncor1 Max Ep300 Kat2b Rbbp4 Rbbp7 Crebbp Smad7 Ncor2 Tnf Nfkb1 Yy1 Rela Gata1 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Exoc1 Itga7 Nme1 Itga8 Exoc2 Dnm2 Pip5k1c Itga5 Spag9 Itga6 Avpr2 Itga9 Exoc7 Bin1 Ins2 Itga4 Ctnnd1 Itga1 Mapk8ip3 Itga2 Cpe Arf6 Itga10 Itga11 Itgav Itgb1 Pld1 Pld2 Ctnnb1 Klc1 Tshr Itga3 Cdh1 Asap2 Cltc Agtr1a Slc2a4 Adrb2 Scamp2 Acap1 Rala Exoc3 Exoc4 Ctnna1 Exoc5 Exoc6 Vamp3 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Cdkn1b Mapk10 Ep300 Csnk1a1 Csnk1g3 Ran Csnk1g1 Fasl Kat2b Mapk8 Bcl2l11 Csnk1g2 Zfand5 Skp2 Fbxo32 Ralb Mst1 Sod2 Crebbp Usp7 G6pc1 Rbl2 Cat Csnk1d Sgk1 Csnk1e Ywhah Cdk2 Sirt1 Ywhag Ywhae Ywhab Chuk Akt1 Sfn Foxo4 Plk1 Foxo3 Foxo1 Ikbkb Ywhaz Mapk9 Ctnnb1 Bcl6 Gadd45a Rala SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Gna15 Gna14 Abcc1 Gnaq Sphk1 Gna13 S1pr1 S1pr3 S1pr4 S1pr2 Sgpp1 Gnai1 Gnai3 Sphk2 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna11 Sgpl1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Cdkn1b Src Prkdc Prkaca Raf1 Bcl2l1 Ywhah Ywhag Ywhae Pdpk1 Cdkn1a Ywhab Chuk Akt1 Sfn Foxo4 Rictor Bad Mtor Map3k5 Akt3 Foxo3 Akt2 Foxo1 Gsk3b Casp9 Tbc1d4 Ywhaz Kpna1 Mapkap1 Gsk3a Mlst8 Slc2a4 Hsp90aa1 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Src Nme1 Pip5k1c Afdn Pik3r1 Vav2 Ctnnd1 Rap1a Itgae Arf6 Itgb7 Rhoa Crk Rac1 Akt1 Rap1b Ccnd1 Ctnnb1 Cdh1 Tiam1 Nckap1 Iqgap1 Klhl20 Ap1m1 Wasf2 Pik3ca Jup Cttn Tjp1 Dlg1 Ctnna1 Rapgef1 Cyfip2 Abi1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Dhh Hhip Ihh Lrp2 Gli2 Hhat Shh Pik3r1 Grk2 Akt1 Lrpap1 Ptch2 Smo Arrb2 Ptch1 Boc Gas1 Pthlh Cdon Pik3ca Tgfb2 Stil POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk3 Plk4 Plk2 Plk1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Jun Stat5a Stat3 Racgap1 Mapk8 Ncf1 Ncf2 Brk1 Arhgdia Noxa1 Bcar1 Map2k4 Baiap2 Atf2 Rac1 Iqgap3 Arpc1b Actr2 Plcb2 Actr3 Arhgap5 Pak2 Wasf1 Arpc3 Map3k1 Noxo1 Arpc2 Pak1 Cyba Abi2 Cybb Arpc5 Pip5k1a Arpc4 Map3k11 Nox1 Ctnnb1 Mapk14 Cdh1 Iqgap1 Cfl1 Map2k3 Ctnna1 Limk1 Pip5k1c Pip5k1b Crk Mapk9 Map2k7 Map2k6 Nckap1 Wasf2 Cyfip2 Abi1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Arr3 Cnga3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Rdh5 Gnb3 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Spata13 Arhgef9 Nme1 Fgd1 Git1 Ngef Dnmbp Mcf2 Arhgap17 Dock10 Dock11 Vav2 Ralbp1 Farp2 Racgap1 Dock6 Bcar3 Arhgef25 Apc Arhgap1 Itsn2 Arhgdia Vav3 Itsn1 Plcg1 Arhgef7 Mcf2l Arhgef6 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Ep300 Kdr Sp1 Adora2a Flt1 Epo Eif3e Ets1 Bhlhe40 Vegfa Hif1an Crebbp Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Pou5f1 Sirt1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn Arnt Elk1 Twist1 Serpine1 Efna1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Jun Mdm2 Pou2f1 Mapk8 Nr2c1 Hdac7 Map2k4 Sirt1 Gata2 Hdac1 Foxo1 Rel Mapk14 Hsp90aa1 Nr3c1 Smarca2 Pkn1 Src Ep300 Ar Ncoa2 Ncoa1 Cebpa Kat2b Crebbp Rack1 Hoxb13 Nr2c2 Kat7 Nr0b1 Egr1 Spdef Rxrb Rxra Gsk3b Smarce1 Kat5 Ehmt2 Rxrg Senp1 Carm1 Dnaja1 Zmiz2 Map2k6 Trim24 Appbp2 Pde9a Smarcc1 Tmprss2 Rchy1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Jun Crkl Pik3r1 Fos Elk1 Plcg1 Srf Cav1 Grb2 Itgav Sos1 Crk Pik3ca Cav3 Jak1 Shb Shf Pdgfra Rapgef1 Shc1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Ptn Src Mc4r Pomc Psen1 Agrp Egfr Fgf23 Fgfr3 Fgfr4 Fgf15 Cask Cttn Fyn Ncstn Aph1b Sdc3 Ncan SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Jun Mapk11 Cebpb Gdi1 Eif4ebp1 Pla2g4a Mitf Rab5a Elk4 Hspb1 Mapkapk3 Usf1 Mapkapk2 Krt8 Trp53 Eif4e Mapkapk5 Mef2a Rps6ka4 Esr1 Rps6ka5 Hbp1 Ptgs2 Mknk1 Atf2 Atf6 Mef2c Creb1 Slc9a1 Mapk14 Ddit3 Nos2 Ppargc1a ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Src Pxn Tln1 Git1 Prkaca Itga4 Arf6 Ptk2 Itgb1 Crk Bcar1 Spp1 Rac1 Prkar1a Dock1 Prkar1b Mdk Jaml Fn1 Jam2 Cd81 Ptk2b Ptpra Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Ywhaz Abi1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Dkk1 Ror2 Wnt1 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt7b Wnt3a Wnt7a Wnt2 Fzd10 Wnt3 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd7 Fzd6 Kremen1 Fzd9 Rspo1 Fzd8 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Fosl1 Cdkn1b Jun Fos Il2 Il4 Ifng Nfatc1 Csf2 Junb Ets1 Nfatc3 Myb Nfatc2 Atf2 Il10 Th Mmp9 Plau Gata2 Myc Tgfb1 Creb1 Ccn1 Ctnnb1 Col1a2 Acta1 Cdkn2a Cdk1 Pten Atf3 Maf Nr3c1 Ep300 Dmp1 Gja1 Edn1 Elf1 Penk Trip6 Il5 Dmtf1 Sp1 Mt2 Nts Mafg Crtc1 Bag1 Fosb Bcl2l11 Tcf7l2 Cops5 Cbfb Trp53 Fabp4 Timp1 Agt Esr1 Nppa Fosl2 H2-Q10 Egr1 Ccnd1 Hif1a Il6 Ccl12 Mmp1a Jund Dusp1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Stat5a Lyn Ptpn11 Pik3r1 Il5 Grb2 Stat5b Pim1 Jak2 Csf2rb2 Pik3ca Il5ra Cish Sdcbp INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Jun Pxn Ilk Rac1 Myl12a Ilkap Ruvbl1 Rhog Ppp1r14a Ppp1r12a Ppp1r14c Ppp1r14b Elmo2 Nck2 Tns1 Git2 Parvg Tacc3 Akt1 Snai1 Lims2 Rictor Zeb1 Ccnd1 Actn1 Parvb Gsk3b Zyx Creb1 Cdc37 Parva Ctnnb1 Ckap5 Parp1 Ruvbl2 Diaph1 Iqgap1 Aurka Hsp90aa1 Arhgef7 Arhgef6 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Gja1 Pip5k1c Ptpn11 Pik3r1 Ctnnd1 Cdh2 Mapk8 Ptpn1 Rhoa Rac1 Fer Gsn Lrp5 Plcg1 Rock1 Ctnnb1 Daglb Camk2g Mapre1 Dctn1 Gap43 Kif5b Cnr1 Fgfr1 Pik3ca Jup Gria2 Cttn Dagla Axin1 Myl2 Ctnna1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Thrb Thra Bcl2 Nr1h4 Nr1h3 Nr1h2 Ppard Ncoa1 Ppara Abca1 Srebf1 Nr4a1 Vdr Pparg Ncor2 Tgfb1 Rxrb Rxra Tnf Rxrg Fam120b Rara Rarb Med1 Rarg P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Trp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Jun Stat5a Ctsd Hdac4 Col18a1 Mpg Nrip1 Sra1 Ube2m Apbb1 Ebag9 Safb Phb2 Pdia2 Anp32a Ddx17 Ap1b1 Ddx54 Pou4f1 Lcor Pou4f2 Nr0b2 Cd82 Trim59 Dscam Pgr Axin2 Ncoa7 Atp5pf Chuk Myc C3 Hdac1 Mta1 Greb1 Hsf2 Ncoa3 Xbp1 Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Uba3 Nedd8 Ncor1 Ep300 Cebpb Ncoa2 Ncoa1 Lmo4 Prl Pcna Brca1 Esr1 Smad4 Ncor2 Nr0b1 Ccnd1 Med1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Stat5a Itga5 Pik3r1 Mapk8 Mapk1 Mapk3 Itgb1 Ets1 Rac1 Fyn Mmp2 Pld2 Dok2 Pak1 Akt1 Foxo1 Mapk14 Grb14 Fgf2 Angpt2 Stat5b Angpt4 Agtr1a F2 Fes Elf2 Tnip2 Plg Bmx Grb7 Shc1 Rasa1 Pxn Elf1 Ptpn11 Angpt1 Nck1 Ptk2 Grb2 Crk Nos3 Fn1 Tek Cdkn1a Elk1 Tnf Nfkb1 Pik3ca Rela DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Fosl1 Jun Nras Il2ra Prkcb Fos Prkce Il2 Ifng Fasl Mapk8 Mapk1 Nfatc1 Mapk3 Junb Nfatc3 Nfatc2 Il2rg Tnfrsf4 Il2rb Prkcq Tnfrsf9 Ifna16 B2m Gzmb Ifnar1 Eomes Ifnar2 Egr4 Cd8a Cd8b1 Tnfrsf18 Raf1 Prkca Hras H2-Q10 Map2k2 Map2k1 Ptpn7 Stat4 Braf Elk1 Egr1 Cd3e Tnf Mapk9 Cd3g Cd247 Prf1 Cd3d Kras SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Jun Itga5 Rras Pik3r1 Mapk8 Mapk1 Itgav Itgb1 Ets1 Rhoa Bcar1 Map2k4 Rac1 Dock1 Elmo1 Fyn Yes1 Wasl Pak1 Rock2 Acta1 Itgb5 Bmx Grb7 Arhgef7 Rasa1 Src Tln1 Pxn Vcl Arhgef11 Asap1 Nck1 Rap1a Arhgef28 Mapk8ip3 Sh3gl1 Arhgap26 Capn2 Ptk2 Raf1 Klf8 Ptpn21 Grb2 Sos1 Crk Arhgap35 Map2k1 Nck2 Git2 Braf Rap1b Actn1 Ccnd1 Plcg1 Mapk9 Pik3ca Rapgef1 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Lamb3 Lama2 Lamb1 Lama5 Lama1 Lamc2 Lama3 Itgb4 Itga6 Lamb2 Lamc1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Fancl Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad50 Fancd2 Topbp1 Brca1 H2ax Ube2t Blm Atm Chek1 Rad9a Top3a Wdr48 Fanci Fancm Usp1 Fancb Palb2 Rfc5 Rfc3 Faap100 Rfc2 Rpa1 Rpa2 Hus1 Rad17 Atrip Brip1 Cenps Brca2 Fbxw11 Xrcc3 Rad1 Faap24 Fan1 Hes1 Btrc VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Krt14 Wwp1 Rab38 Krt5 Nrg1 Cebpd Mre11a Adrm1 Il1a Axl Fbxw7 Perp Trp63 Top2a Mdm2 Vdr Hbp1 Fosl2 Atm Ada Rack1 Sfn Col5a1 Brca2 Gsk3b Yap1 Dlx5 Hes1 Bdkrb2 Itga3 Ppp2r5a Hells Igfbp3 Cdkn2a Itch Sec14l2 Stxbp4 T Fasn Tcf7l1 Pou2f2 Notch1 Ccnb2 Gpx2 Rrad CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Srebf1 Madd App Arhgdib Tnfrsf1a Slk Tradd Cfl2 Xiap Cradd Sptan1 Traf2 Lmna Apaf1 Gas2 Top1 Tfap2a Vim Numa1 Lmnb1 Bax Lmnb2 Pidd1 Casp7 Gsn Krt18 Casp4 Satb1 Casp2 Map3k1 Casp1 Diablo Dffa Dffb Birc3 Acta1 Limk1 Gzmb Bcl2 Ptk2 Casp6 Tnf Casp9 Birc2 Parp1 Prf1 Bid Casp8 Casp3 Ripk1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Spata13 Rasgrf1 Ngef Mcf2 Arhgap17 Vav2 Ralbp1 Racgap1 Dock6 Arhgef25 Arhgap1 Sos1 Arhgdia Rac1 Dock1 Elmo1 Vav3 Trio Tiam2 Arhgef2 Dock2 Abr Eps8 Def6 Rap1gds1 Prex1 Vav1 Bcr Kalrn Arhgap9 Tiam1 Arhgef7 Abi1 Arhgef6 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Tln1 Itgam Rap1a Rhoa Mst1 Itgb2 Jam2 Mmp2 Mmp9 Plau Myh2 Thy1 Rap1b Hck Selp Rock1 Tnf Lrp1 Il6 Selplg Ccn2 Jam3 Plat Ager Nfkb1 Icam1 Plaur Mst1r Apob Plg ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Nme1 Pip5k1a Arf6 Kalrn Mapk1 Tiam1 Mapk3 Rhoa Plaur Rac1 Arf1 Pld1 Rab11fip3 Rab11a Pld2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Jun Prkcb Pik3r1 Pla2g4a Fos Mapk8 Mapk1 Mapk3 Map2k4 Nfatc2 Fyn Syk Pld2 Pak2 Map3k1 Lyn Chuk Inpp5d Akt1 Cbl Vav1 Itk Plpp1 Fcer1a Klrg1 Gab2 Shc1 Hcls1 Rasa1 Cblb Wipf1 Fcer1g Pxn Lat2 Lcp2 Ptpn13 Ptpn11 Pla2g1b Ms4a2 Fcgr2b Ptk2 Dok1 Raf1 Grb2 Sos1 Hras Fer Lat Map2k2 Map2k1 Sphk1 S1pr1 Plcg1 Ikbkb Ikbkg Map2k7 Nfkb1 Pik3ca Dusp1 Btk Rela S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Src Cxcr4 Gnai1 Gnai3 Mapk1 Flt1 Mapk3 Pdgfrb Rhoa Vegfa Pdgfb Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Gna13 S1pr3 Akt1 Akt3 Jak2 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Vcam1 Pxn Itgb7 Itgb1 Rhoa Itga4 Madcam1 Ptk2 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Crkl Rasgrf1 Nras Stat3 Pik3r1 Mapk1 Mapk3 Rhoa Rac1 Dock1 Elmo1 Mcf2l Gab2 Shc1 Rasa1 Bdnf Ptpn11 Rap1a Ngf Gab1 Frs3 Matk Frs2 Sqstm1 Faim Prkci Maged1 Ngfr Dnaja3 Ntf4 Grb2 Shc3 Ntf3 Sos1 Shc2 Crk Gipc1 Rgs19 Hras Nedd4l Abl1 Arhgap32 Rit1 Rit2 Ehd4 Ntrk2 Rhog Ntrk1 Map2k1 Ntrk3 Rap1b Dnm1 Ccnd1 Plcg1 Tiam1 Pik3ca Rapgef1 Kras Prkcz CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Lck Src Nras Pik3r1 Rap1a Arf6 Rhoa Hras Rac1 Blk Fyn Lat Yes1 Syk Cyth2 Sgk1 Zap70 Cyth3 Cyth1 Dapp1 Pdpk1 Inppl1 Lyn Plekha2 Plekha1 Plcg2 Inpp5d Blnk Arap3 Fgr Adap1 Pik3cg Hck Arf5 Pik3r6 Foxo3 Plcg1 Pik3cb Arf1 Pik3ca Pten Itk Hsp90aa1 Btk Kras ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Wwp1 Stat5a Nrg1 Pik3r1 Prl Prlr Mdm2 Mapk1 Grb2 Mapk3 Fyn Tab2 Wwox Erbb2 Erbb4 Lrig1 Adam17 Hbegf Ereg Yap1 Nrg2 Btc Cbfa2t3 Stat5b Nrg4 Nrg3 Dlg4 Itch Pik3cb Jak2 Grin2b Pik3ca Ncor1 Shc1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Stat5a Nras Stat3 Stat1 Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk1 Grb2 Csf2 Mapk3 Sos1 Hras Csf2rb2 Cish Syk Map2k2 Prkacb Map2k1 Lyn Inpp5d Ikbkb Ywhaz Ccl12 Pim1 Stat5b Jak2 Csf2ra Pik3ca Osm Irf8 Kras Shc1 Gab2 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Pkn1 Mapk12 Map2k6 Mapk13 Map2k3 Ccnd1 Eef2k Map3k20 Snta1 Stmn1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Aqp5 Kifc3 Mgat3 Aqp3 Git1 Pip5k1c Nectin2 Lpp Afdn Vcl Myo6 Epha2 Stx4 Nck1 Plekha7 Ctnnd1 Camsap3 Egfr Arf6 Rhoa Egf Igf1 Igf1r Hgf Actn1 Rock1 Zyx Ctnnb1 Cdh1 Diaph1 Nckap1 Met Exoc3 Exoc4 Myl2 Ctnna1 Cyfip2 Lima1 Abi1 Vasp Efna1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Mapk11 Prkcb Prkaca Pik3r1 Myof Cdh5 Ptprj Camkk2 Akap1 Mapkapk2 Sh2d2a Mapk1 Hsp90ab1 Hgs Itgav Ptpn2 Mapk3 Vtn Rhoa Fyn Pak2 Ptk2b Itgb3 Ptpn6 Akt1 Cbl Fbxw11 Cav1 Ctnnb1 Mapk14 Iqgap1 Fes Arf1 Map2k3 Hsp90aa1 Ctnna1 Src Pxn Dnm2 Grb10 Vcl Kdr Ptpn11 Nck1 Gab1 Ptk2 Raf1 Grb2 Flt1 Prkca Vegfa Nos3 Map2k2 Map2k1 Pdpk1 Nck2 Braf Plcg1 Rock1 Prkcd Map2k6 Pik3ca Shb VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Fosl1 Birc5 Npm1 Eif4e Riox2 Peg10 Bmi1 Ndufaf2 Bax Bcat1 Ddx18 Trrap Shmt1 Taf12 Rcc1 Hspd1 Mmp9 Prdx3 Supt3 Cad Nme2 Taf4b Myc Mtdh Actl6a Mta1 Ldha Cdc25a Serpini1 Odc1 Taf9 Eif4g1 Gpam Rpl11 Id2 EG433182 Eif2s1 Supt7l Pfkm Pim1 Lin28b Myct1 Ccnd2 Tfrc Polr3d Hmga1 Pdcd10 Hspa4 Ireb2 Eif4a1 Hsp90aa1 Ubtf E2f3 Huwe1 Tert Tk1 Max Nme1 Ep300 Nbn Kat2a Trp53 Crebbp Smad3 Smad4 Slc2a1 Ruvbl1 Cdk4 Snai1 Kat5 Ruvbl2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Dusp16 Lck Src Traf6 Mapk11 Pak3 Prkg1 Map3k3 Ccm2 Map3k12 Ralb Map2k4 Rac1 Blk Fyn Yes1 Tab1 Pak2 Pak1 Lyn Fgr Hck Mapk14 Map2k6 Rala Dusp1 Map2k3 Ripk1 Dusp10 Dusp8 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Stat5a Crkl Stat3 Stat1 Pik3r1 Mitf Mapk8 Socs1 Mapk3 Lyn Ptpn6 Akt1 Cbl Foxo3 Vav1 Pten Kit Shc1 Bcl2 Grb10 Ptpn11 Stap1 Ptpro Spred1 Gab1 Spred2 Matk Epor Grap2 Dok1 Raf1 Pik3c2b Snai2 Sh2b2 Kitlg Sh2b3 Map4k1 Grb2 Tec Epo Sos1 Hras Crebbp Fer Map2k2 Map2k1 Pdpk1 Bad Gsk3b Jak2 Pik3ca GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Bmp4 Fgf7 Gpc3 Shh Furin Ptch1 Mapk9 Mapk8 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Src Pxn Itga9 Csf2 Itgb1 Bcar1 Vegfa Spp1 Tnc Rac1 Adam12 Adam15 Sat1 Vegfd Fn1 Vegfc Tgm2 Paox Adam2 F13a1 Adam8 Vcam1 Kcnj15 Csf2ra Nos2 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Pnkp Prkdc Polm Nhej1 Dntt Aptx Dclre1c Lig4 Aplf Xrcc4 Poll Xrcc6 Xrcc5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Jun Crkl Pik3r1 Eif4ebp1 Rab5a Ptprj Mapk8 Mapk1 Eif4e Hgs Ptpn2 Mapk3 Ets1 Rhoa Bcar1 Map2k4 Rac1 Pak2 Map3k1 Wasl Pak1 Inpp5d Akt1 Cbl Mtor Ctnnb1 Cdh1 Pard6a Ctnna1 Gab2 Shc1 Sh3gl2 Src Pxn Ptpn11 F2rl2 Nck1 Rap1a Gab1 Arf6 Ptk2 Raf1 Prkci Apc Grb2 Sos1 Ptpn1 Crk Hras Map2k2 Map2k1 Pdpk1 Inppl1 Nck2 Rap1b Snai1 Egr1 Hgf Bad Plcg1 Akt2 Rptor Kpnb1 Numb Sh3kbp1 Eps15 Mlst8 Ranbp9 Rin2 Arhgef4 Met Deptor Pak4 Akt1s1 Pik3ca Muc20 Ranbp10 Rapgef1 Prkcz EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Src Tln1 Pip5k1c Nras Stat3 Stat1 Ptpn11 Pik3r1 Nck1 Gab1 Egfr Ptk2 Gnai1 Gnai3 Mapk1 Grb2 Mapk3 Ptpn1 Sos1 Hras Gsn Egf Wasl Pak1 Nck2 Ptpn6 Plcg1 Pik3cb Pik3ca Kras Shc1 Rasa1 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Snx2 Pkn1 Gng2 Snx1 Arrb1 Dnm2 Akap13 Prkcg Prkcb Gnb1 Pik3r1 F2rl2 Gnai1 Gnai3 Prkca Arhgdia Rhoa Gna12 Gnaz Nos3 Gnao1 Plcb2 Gnai2 Gna11 Gna15 Gna14 Rock2 Gnaq Gna13 Dnm1 Rock1 Zyx Prkcd F2 Pik3ca Plcb3 F2r Myl2 Arhgef1 Plcb1 Trpc6 Vasp Grk3 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Dnm2 Itga5 Cxcl12 Sdc4 Fgf6 Cxcr4 Nudt16l1 Tfpi Ptk2 Prkca Itgb1 Gipc1 Rhoa Tnc Rac1 Adam12 Mdk Ccl5 Fn1 Tnfrsf13b Mmp9 Sdcbp Lama1 Lama3 Thbs1 Actn1 Prkcd Fgf2 F2 Fgfr1 Plg Fzd7 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Mdm2 Smyd2 Cse1l Kat8 Mapk8 Fbxo11 Ppp1r13l Prmt5 Kmt5a Dyrk2 Ptpa Rpl23 Ube2d1 Ccng1 Chek2 Setd7 Cop1 Ttc5 Pin1 Mdm4 E4f1 Ppm1d Daxx Akt1 Ppp2ca Rpl11 Mapk14 Nedd8 Cdkn2a Huwe1 Ep300 Trim28 Csnk1a1 Csnk1g3 Csnk1g1 Kat2b Csnk1g2 Trp53 Skp2 Crebbp Atm Usp7 Chek1 Abl1 Csnk1d Hipk2 Csnk1e Cdk2 Ccna2 Gsk3b Kat5 Prkcd Mapk9 Rchy1 Yy1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Fosl1 Cblb Jun E2f1 Egr4 Il2ra Il5 Fos Batf3 Il2 Il4 Pou2f1 Ifng Fasl Cd40lg Nfatc1 Csf2 Ptpn1 Junb Nfatc3 Ptgs2 Nfatc2 Pparg Cdk4 Rnf128 Ctla4 Irf4 Ptprk Dgka Slc3a2 Egr3 Ikzf1 Foxp3 Egr1 Tnf Egr2 Itch Gata3 Tbx21 Casp3 Prkcq Maf E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Cdh1 Jup Ctnnb1 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Gna15 Irs1 Jun Gna14 Pak1 Gnaq Gna13 Fos S1pr2 Elk1 Cdh5 Gnai1 Gnai3 Mapk14 Mapk8 Mapk1 Mapk3 Rhoa Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Src Gng2 Ar Gnb1 Pik3r1 Fos Ptk2 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Rac1 Gnaz Gnao1 Plcb2 Gnai2 Map2k2 Map2k1 Plcg2 Akt1 Gnrh1 Shbg Pelp1 Plcg1 Creb1 Pik3ca Plcb3 Plcb1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Plk3 Trp53 Chek2 Cdc25c Ccne1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Fosl1 Ep300 Jun Gja1 Dmtf1 Sp1 Nfatc1 Junb Nfatc3 Itgb4 Fosl2 Nfatc2 Nos3 Mmp2 Mmp9 Plau Lama3 Ccna2 Ccnd1 Hmox1 Txlng Usf2 Il6 Lif Col1a2 Dcn Ccl12 Thbd Mgp Mmp1a Atf4 Jund Cdkn2a Plaur ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Trim28 Mre11a Nbn Mdm2 Rad50 Fancd2 Brca1 H2ax Blm Atm Chek2 Abl1 Rad9a Top3a Cop1 Ctbp1 Ywhab Rad17 Cdc25a Dclre1c Xrcc4 Kat5 Mdc1 Terf2 Smc3 Ube2n Abraxas1 Bid Rbbp8 Uimc1 Trp53bp1 Smc1a Cdc25c HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Nfkbia Bcl2 Tnfrsf1a Bag4 Fasl Tradd Mapk8 Cradd Traf2 Casp6 Apaf1 Casp7 Casp2 Daxx Chuk Map3k14 Map3k5 Tnf Birc3 Casp9 Map2k7 Cd247 Nfkb1 Cflar Bid Casp8 Casp3 Traf1 Ripk1 Fas Rela Fadd ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Sftpa1 Myd88 Ly96 Tlr1 Chuk Vcan Cd14 Irak4 Ticam1 Tlr6 Tirap Tlr4 S100a9 S100a8 Tlr3 Tlr2 Ikbkb Ikbkg Rhoa Irak2 Irak1 Saa3 Hspd1 Bgn IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Stat5a Il1b Stat3 Stat1 Il2 Ifng Ebi3 Il6st Il12a Il12rb2 Il27 Il27ra Stat2 Jak1 Stat4 Tgfb1 Il12b Il18 Tnf Il6 Jak2 Il12rb1 Gata3 Tyk2 Tbx21 Il17a P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Mapk10 Psen1 Pik3r1 App Mapk8 Xiap Apaf1 Arhgdia Rhoa Rac1 Prkacb Diablo Chuk Akt1 Birc3 Plg Irak1 Shc1 Traf6 Myd88 E2f1 Bdnf Ngf Sqstm1 Prkci Bcl2l11 Maged1 Ngfr Trp53 Ntf4 Ntf3 Casp6 Rhoc Rhob Lingo1 Furin Mmp3 Omg Mag Mageh1 Smpd2 Bex3 Bex1 Nsmce3 Ntrk1 Rtn4 Ywhae Ripk2 Mmp7 Ndn Prdm4 Sort1 Zfp369 Bad Adam17 Casp9 Ikbkb Mapk9 Birc2 Ikbkg Pik3ca Casp3 Ncstn Aph1b Prkcz CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Pip5k1b Nkd2 Ranbp3 Dvl1 Lrp6 Klhl12 Dvl2 Dvl3 Pi4k2a Gsk3b Cav1 Csnk1g1 Apc Wnt3a Ctnnb1 Gsk3a Ppp2r5a Cul3 Fzd5 Axin1 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Src Jun Stat1 Ptpn11 Pik3r1 Fos Ctnnd1 Gab1 Frs2 Cdh2 Runx2 Sdc2 Mapk1 Grb2 Mapk3 Sos1 Fgf15 Spp1 Spry2 Ptk2b Mmp9 Plau Pdpk1 Camk2a Akt1 Cbl Plcg1 Klb Il17rd Fgf1 Ncam1 Fgf23 Fgfr3 Ssh1 Fgfr4 Fgfr2 Cdh1 Rps6ka1 Stat5b Plaur Pak4 Fgfr1 Pik3ca Cttn Shc1 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Smad1 Acvr1 Tlx2 Smad9 Amhr2 Fkbp1a Amh Bmp7 Smad5 Smad4 Bmpr2 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Cmtm2b Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Pawr Snurf Appl1 Ube2i Hnrnpa1 Ncoa6 Pias1 Ccnd3 Nrip1 Kdm3a Tgfb1i1 Tcf4 Vav3 Gsn Pias3 Ptk2b Tgif1 Pias4 Akt1 Pelp1 Srf Ctnnb1 Uba3 Cdkn2a Prkdc Ar Ncoa2 Xrcc6 Brca1 Xrcc5 Cdk6 Ccnd1 Carm1 Ranbp9 Hip1 Lats2 Tmprss2 Fhl2 Casp8 Kdm4c Kdm1a Znf318 Prdx1 Fkbp4 Patz1 Med1 Rps6ka3 Mak E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Src Pip5k1a Pik3r1 Akt1 Ctnnd1 Plcg1 Egfr Akt2 Zyx Ctnnb1 Casr Ajuba Cdh1 Rhoa Rac1 Pik3ca Jup Fyn Ctnna1 Vasp IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Jun Mapk11 Cebpb Stat3 Cebpd Stat1 Ptpn11 Pik3r1 Fos Mitf Lmo4 Gab1 Pias1 Il6st Grb2 Crp Timp1 Hsp90b1 Junb Sos1 Lbp Mcl1 Map2k4 Ptpre Rac1 Fgg Tnfsf11 Jak1 A2m Pias3 Bcl2l1 Il6ra Myc Socs3 Akt1 Hck Vav1 Foxo1 Prkcd Il6 Mapk14 Map2k6 Jak2 Pik3ca Tyk2 Irf1 Gab2 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha2 Epha3 Epha4 Epha5 Epha6 Epha7 Efna5 Epha8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Nbn Rad51 Mdm2 Fancd2 Topbp1 Chek1 Rad9a Mcm7 Smarcal1 Ppp2r2b Timeless Cep164 Cdk2 Cdc6 Rfc5 Tipin Rfc3 Mcm2 Ywhab Rfc2 Rpa1 Rpa2 Hus1 Rad17 Cdc25a Ppp2ca Atrip Plk1 Ccna2 Clspn Brca2 Fbxw11 Rad1 Ywhaz Ppp2r1a Btrc Cdc25c DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Axin2 Cul1 Skp1 Dvl1 Lrp6 Dvl2 Dvl3 Csnk1a1 Gsk3b Apc Wnt3a Ctnnb1 Gsk3a Fzd5 Btrc Axin1 Csnk1d Csnk1e IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Irs1 Pxn Irs2 Crkl Grb10 Ptpn11 Pik3r1 Ptk2 Raf1 Grb2 Ptpn1 Sos1 Crk Bcar1 Hras Igf1 Ywhae Pdpk1 Rack1 Nck2 Igf1r Prkd1 Akt1 Bad Prkcd Ywhaz Pik3ca Shc1 Prkcz CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Pgr Vcam1 Il1b Nlrp1a Antxr2 Antxr1 Il18 Tnf Mapk1 Map2k7 Map2k6 Mapk3 Map2k4 Map2k3 Map2k2 Casp1 Map2k1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Gnb1 Gngt1 Slc24a1 Rdh12 Pde6a Pde6b Rgs9bp Gnat1 Cnga1 Pde6g Rho Sag Grk1 Gucy2e Rpe65 Rdh5 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Ep300 Birc5 Fos Sp1 Gas1 Aurkb Skp2 Nfatc3 Esr1 Crebbp Chek2 Mmp2 Cdk4 Cdk2 Map2k1 Myc Plk1 Ccna2 Ccnd1 Brca2 Cenpb Gsk3a Hspa1a Onecut1 Nek2 Rb1 Cdkn2a Foxm1 Cdk1 Cks1b Tgfa Lama4 Xrcc1 Etv5 Cenpf Cenpa Ccnb2 Cdc25b Ccne1 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Gng2 Arrb1 Prkcg Prkcb Gnb1 Grk2 Prkce Rab5a Prkca Pld1 Plcb2 Gnai2 Gna15 Gna14 Pdpk1 Lyn Akt1 Fgr Pik3cg Hck Cbl Dnm1 Pik3r6 Arrb2 Plcb3 Cxcr1 Plcb1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Fga F10 Tgfbi Itgax F11r Icam4 Icam2 Itgam Itgal Fcgr3 Cd40lg Itgad Itgb2 Fgg Kng2 Plau Vcam1 C3 Thy1 Ccn1 Jam3 Plat Icam1 Plaur Spon2 Proc Gp1ba Fgb INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Gm14226 Gys1 Stx4 Ppp1cc Ins2 Lnpep Rhoq Trip10 Ppp1r3a Vamp2 Prkci Insr Ywhah Ywhag Ywhae Ywhab Akt1 Sfn Akt2 Gsk3b Tbc1d4 Ywhaz Slc2a4 Stxbp4 Prkcz PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Mapk10 Stat5a Stat3 Stat1 Pik3r1 Eif2ak2 Ptprj Mapk8 Mapk1 Itgav Ptpn2 Mapk3 Brk1 Ksr1 Arhgdia Rhoa Bcar1 Map2k4 Baiap2 Rac1 Arpc1b Blk Actr2 Actr3 Ppp2r2b Arpc3 Arpc2 Itgb3 Pak1 Lyn Arpc5 Arpc4 Fgr Ppp2ca Hck Srf Ppp2r1a Pten Shc1 Rasa1 Src Grb10 Ptpn11 Nck1 Rap1a Gab1 Sla Dok1 Arap1 Rab4a Usp6nl Grb2 Tagln Prkca Myocd Dock4 Sos1 Ptpn1 Actn4 Crk Csk Nherf2 Hras Nherf1 Sipa1 Ywhah Ywhag Ywhae Ywhab Braf Sfn Elk1 Plcg1 Prkcd Ywhaz Mapk9 Jund Kras Jun Nras Prkce Pla2g4a Fos Vav2 Rab5a Fyn Yes1 Pin1 Wasl Myc Eps8 Pik3cg Pik3r6 Cbl Lrp1 Stat5b Iqgap1 Lck Dnm2 Afdn Raf1 Pdgfrb Pdgfb Abl1 Pag1 Arhgap35 Map2k2 Map2k1 Nck2 Sphk1 S1pr1 Rap1b Map2k7 Nckap1 Pik3cb Jak2 Wasf2 Pik3ca Cttn Rapgef1 Cyfip2 Rps6ka3 Abi1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Src Tln1 F11r Pip5k1c Nectin2 Afdn Pik3r1 Vav2 Rap1a Farp2 Ptk2 Itgav Pdgfrb Crk Pdgfb Rac1 Nectin1 Nectin3 Ptprm Cldn1 Itgb3 Rap1b Ctnnb1 Cdh1 Iqgap1 Pik3ca Ctnna1 Rapgef1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Nfkbia Jun Pik3r1 Fos Vav2 Mapk8 Mapk1 Nfatc1 Mapk3 Ets1 Rac1 Syk Map3k1 Lyn Chuk Inpp5d Ptpn6 Akt1 Map3k7 Mapk14 Pten Shc1 Rasa1 Traf6 Fcgr2b Dok1 Raf1 Ppp3ca Map4k1 Grb2 Sos1 Csk Hras Pag1 Cd72 Cd22 Malt1 Card11 Map2k1 Dapp1 Cd79a Pdpk1 Cd79b Ibtk Bcl10 Plcg2 Ptprc Blnk Nfkbib Ppp3cc Ppp3cb Elk1 Cd19 Bcl2a1d Sh3bp5 Ikbkb Ikbkg Camk2g Nfkb1 Pik3ca Pou2f2 Btk Rela REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Cdkn1b Arhgef15 Ngef Akap13 Mcf2 Arhgef11 Vav2 Arhgef28 Arhgdib Arhgef25 Arap1 Arhgdia Rhoa Arhgap35 Vav3 Arhgap5 Trio Ect2 Arhgef2 Abr Arap3 Def6 Srgap1 Vav1 Arhgef3 Bcr Ophn1 Arhgap9 Arhgef17 Arhgdig Arhgef10 Arhgef12 Myo9b Arhgef18 Plekhg6 Arhgap6 Net1 Farp1 Arhgap4 Arhgef10l Dlc1 Arhgap8 Arhgef1 Mcf2l EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Syt1 Stx1a Stxbp1 Vamp2 Unc13b Chrna1 Snap25 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Mark2 Adam10 Neurl1a Notch4 Notch2 Notch3 Fbxw7 Dtx1 Dll1 Dll3 Il4 Mycbp Dll4 Mfap5 Jag2 Jag1 Mfap2 Dlk1 Mib1 Cntn1 Cntn6 Dner Lnx1 Cul1 Ctbp1 Skp1 Myc Hdac1 Cbl EG433182 Gata3 Btrc Rab11a Ncor1 Ptcra Ep300 Skp2 Furin Adam12 Cdkn1a Spen Ncor2 Dnm1 Ccnd1 Maml1 Maml2 Numb Eps15 Itch Rbbp8 Kdm1a Rbpj Yy1 Notch1 Ncstn Aph1b GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Lck Stat5a Bcl2 Il2ra Elf1 Ptpn11 Pik3r1 Sp1 Il2 Il4 Ccnd3 Fasl Grb2 Sos1 Jak3 Cdk6 Jak1 Bcl2l1 Lta Myc Foxp3 Ccna2 Il2rg Stat5b Prf1 Ccnd2 Pik3ca Il2rb Shc1 Gab2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Mapk10 Src Jun Nrg1 Nras Stat3 Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk8 Mapk1 Grb2 Mapk3 Sos1 Hras Rac1 Erbb3 Nfatc4 Nf2 Chrne Usp8 Rnf41 Map2k2 Dock7 Map2k1 Akt1 Ppp3cb Bad Erbb2 Mtor Mapk9 Nrg2 Pik3cb Jak2 Pik3ca Kras Shc1 Chrna1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Gng2 Arrb1 Prkcg Prkcb Gnb1 Rab5a Prkca Elmo1 Plcb2 Gnai2 Pld2 Rab7 Gna15 Cxcr2 Gna14 Pdpk1 Rac2 Lyn Dock2 Akt1 Fgr Pik3cg Ppp2ca Hck Cbl Dnm1 Pik3r6 Arrb2 Ppp2r1a Plcb3 Rab11a Plcb1 Vasp FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc2 Sdc1 Sdc4 Sdc3 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Fga Tgfbi F11r Kdr Sdc4 Itgav Lamb1 Vtn Pdgfrb Itga2b Vegfa Pdgfb Spp1 Tnc Fgg Fn1 Lamc1 Plau Itgb3 Col1a1 Sphk1 L1cam Col4a3 Thbs1 Pecam1 Col4a4 Thy1 Cd47 Edil3 Ibsp Col4a1 Fbn1 Col4a5 Ccn1 Col4a6 Col1a2 Sdc1 Plaur Lama4 Tgfbr2 Fgb THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Jun Stat5a Mapk11 Nras Stat3 Il2ra Prkcb Stat1 Pik3r1 Fos Prkce Il2 Ifng Mapkapk2 Mapk8 Socs1 Mapk1 Mapk3 Rhoa Jak3 Jak1 Fyn Syk Ptk2b Dok2 Myc Socs2 Stam2 Ikzf3 Stam Mapk14 Il2rg Stat5b Il2rb Gab2 Shc1 Rasa1 Irs1 Lck Bcl2 Irs2 Ptpn11 Raf1 Grb2 Sos1 Hras Cish Map2k2 Cdk2 Map2k1 Socs3 Mapk9 Pik3ca Kras GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc3 Gpc2 Gpc1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Npas2 Nr1d1 Nono Cry1 Cry2 Bhlhe40 Clock Bmal1 Chek1 Per1 Wdr5 Timeless Csnk1e IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Stat5a Il18r1 Il1b Stat3 Il2ra Stat1 Fos Il2 Il4 Ifng Fasl Socs1 Stat6 Sphk2 Atf2 Rab7 Mtor Mapk14 Il2rg Nfkb2 Il2rb Ccr5 Map2k3 Relb Gadd45g Gzma B2m Gadd45b Gzmb Hlx Lck Ccl4 Eomes Il1r1 Cd8a Cd8b1 Il12a Il12rb2 H2-Q10 Ripk2 Stat4 Il12b Il18 Il18rap Cd3e Cd4 H2-Eb1 Cd3g Map2k6 Cd247 Nfkb1 Cd3d Jak2 Il12rb1 Tyk2 Tbx21 Nos2 Rela BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Plau Vcam1 Edil3 Itga4 Madcam1 Fbn1 Ccn1 Itgb8 Itgb6 Itgav Itgb7 Vtn Itgb5 Sdc1 Plaur Tgfbr1 Fn1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Cdkn1b Pik3r1 Mapk1 Ilk Itgav Mapk3 Vtn Rhoa Bcar1 Spp1 Rac1 Vav3 Ptk2b Itgb3 Akt1 Edil3 Cbl Col1a2 Fgf2 Tgfbr2 Hsp90aa1 Irs1 Src Angptl3 Tln1 Pxn Mfge8 F11r Adgra2 Vcl Pi4kb Kdr Pi4ka Ptpn11 Pik3c2a Csf1r Ptk2 Csf1 Vegfa Col11a1 Col11a2 Igf1 Fn1 Col2a1 Col3a1 Col1a1 Col6a1 Igf1r Col5a2 Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Rock1 Col4a5 Col6a3 Col4a6 Sdc1 Casp8 Pik3ca SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Ep300 Tuba1b Mef2d Hdac4 Acss1 Acss2 Hoxa10 Tubb2a Kat2b H1-4 Trp53 Xrcc6 Crebbp Bax Sirt3 Sirt2 Sirt1 Sirt7 Cdkn1a Foxo4 Foxo3 Foxo1 Fhl2 Ppargc1a Myod1 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Ep300 Ncoa2 Prkcg Ncoa1 Prkaca Nrip1 Kat2b Mapk8 Mnat1 Mapk1 Ccnh Vdr Cdk7 Hdac3 Rbp1 Prkca Mapk3 Crebbp Hdac1 Ncor2 Akt1 Ncoa3 Rxrb Rxra Rxrg Mapk14 Cdk1 Rara Rarb Rarg HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Rack1 Eloc Arnt Hif1a Cops5 Trp53 Rbx1 Hif3a Os9 Cdkn2a Hif1an Naa10 Egln2 Cul2 Egln3 Hsp90aa1 Vhl FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Sftpa1 Cdkn1b Ep300 Jun Cebpb Ar Nkx3-1 Shh Fos Ins2 Sp1 Col18a1 Pou2f1 Nrip1 Vtn Brca1 Esr1 Crebbp Ap1b1 Pisd Sftpd Cyp2c55 Nfia Nfic Serpina1d Scgb1a1 Nr2f2 Dscam Gcg Foxa1 Atp5pf Foxa2 Foxa3 Ncoa3 Xbp1 Ndufv3 Prdm15 Apob NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Mapk10 Ror2 Nlk Csnk1a1 Mapk8 Rhoa Nfatc2 Rac1 Pparg Tab2 Yes1 Tab1 Setdb1 Camk2a Daam1 Chd7 Flna Dvl1 Dvl2 Arrb2 Dvl3 Wnt5a Rock1 Mapk9 Map3k7 Cthrc1 Fzd2 Fzd5 Fzd7 Fzd6 Prkcz PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Src Gng2 Mapk11 Nras Gnb1 Pik3r1 Gnai1 Gnai3 Grb2 Sos1 Rhoa Esr1 Bcar1 Hras Gnaz Nos3 Gnao1 Plcb2 Igf1 Gnai2 Mmp2 Gna11 Mmp9 Gna15 Gna14 Rock2 Gnaq Igf1r Gna13 Strn Akt1 Pelp1 Esr2 Hbegf Msn Pik3ca Plcb3 Plcb1 Kras Shc1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Ctnnbip1 Jun Klf4 Pitx2 Bcl9 mt-Co2 Myf5 Mitf Incenp Tcf4 Hbp1 Trrap Mmp2 Mmp9 Hdac2 Axin2 Cul1 Ctbp1 Skp1 Myc Hdac1 Ccn1 Id2 Ctnnb1 Cdh1 Cdkn2a Ccnd2 Btrc Tert Dkk1 Ep300 Lef1 Vcan Ar Ncoa2 Snai2 Apc Tcf7l2 Camk4 Ywhah Ywhag Ywhae Ywhab Neurog1 Cacna1g Sfn Myog Mdfic Igf2bp1 Dvl3 Ccnd1 Cby1 Fgf4 Zcchc12 Tbl1xr1 Ywhaz Kcnip4 Tnik Adcy7 Tle4 Med12 Ruvbl2 Tle2 Krt1 Tle1 Tle5 Dkk4 Chd8 Sall4 T Smarca4 Tcf7 Tcf7l1 Tbl1x Sp5 Cdx4 Cdx1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Stat5a Bcl2 Irs2 Crkl Stat1 Ptpn11 Pik3r1 Vav2 Rap1a Gab1 Epor Mapk8 Sh2b3 Grb2 Tec Epo Sos1 Hras Bcl2l1 Lyn Plcg2 Inpp5d Socs3 Ptpn6 Cbl Plcg1 Mapk14 Stat5b Nfkb1 Jak2 Rapgef1 Btk Shc1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Traf6 Mapk11 Map3k3 Ccm2 Map3k6 Map3k4 Taok1 Taok3 Map3k10 Traf2 Txn Atm Rac1 Tab2 Tab1 Map3k1 Map3k5 Map3k7 Mapk14 Map2k6 Gadd45a Camk2b Map2k3 Gadd45g Gadd45b C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Max Supt3 Myc Actl6a Ppp2ca Fbxw7 Taf9 Pml Gsk3b Kat5 Kat2a Supt7l Skp2 Ruvbl2 Ppp2r5a Hbp1 Cdkn2a Trrap Axin1 Pin1 Ruvbl1 Zbtb17 Taf12 Pak2 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Abcc1 Sphk1 S1pr1 Kdr Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Pdgfrb Rhoa Vegfa Ptgs2 Pdgfb Rac1 Gnaz Gnao1 Plcb2 Gnai2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Lck Src Lyn Lama1 Nrg1 Tgfb1 Fgr Tgfb3 Hck App Prnp Slit2 Serpinc1 Gpc1 Flt1 Fgf2 Vegfa Fgfr1 Blk Smad2 Tgfbr1 Tgfbr2 Fyn Yes1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Jun Prkcg Prkcb Pla2g4a Fos Prkce Mapk8 Ednrb Ednra Mapk1 Adcy3 Adcy4 Mapk3 Adcy1 Rhoa Adcy2 Adcy8 Bcar1 Adcy5 Rac1 Adcy6 Adcy9 Edn2 Plcb2 Edn3 Prkch Cysltr2 Cysltr1 Ptk2b Akt1 Col1a2 Slc9a1 Mapk14 Slc9a3 Prkcq Src Edn1 Gnai1 Raf1 Gnai3 Prkca Crk Hras Gna12 Gnaz Gnao1 Gnai2 Map2k2 Gna11 Map2k1 Col3a1 Gna15 Gna14 Gnaq Prkcd Adcy7 Mmp1a Jak2 Plcb3 Plcb1 Trpc6 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Flt4 Pgf Flt1 Vegfb Vegfa Kdr Vegfd Vegfc Nrp1 Nrp2 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Mapk10 Jun Pik3r1 F2rl2 Nck1 Prkci Mapk8 Grb2 Map2k4 Rac1 Fyn Wasl Nck2 Nphs2 Nphs1 Cd2ap Kirrel1 Akt1 Bad Arrb2 Plcg1 Mapk9 Pard6a Pik3cb Pik3ca Tjp1 Trpc6 Prkcz LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Nfkbia Gng2 Jun Pik3r1 Gnb1 Fos Prkce Adcy3 Adcy4 Adcy1 Rhoa Adcy2 Adcy8 Bcar1 Adcy5 Rac1 Adcy6 Adcy9 Mmp2 Pld2 Ptk2b Mmp9 Lyn Prkd1 Gna13 Akt1 Lpar4 Lpar3 Lpar2 Lpar1 Adra1b Src Pxn Trip6 Gab1 Egfr Gnai1 Ptk2 Gnai3 Crk Nherf2 Hras Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Plcg1 Gsk3b Prkcd Hbegf Adcy7 Tiam1 Nfkb1 Pik3cb Plcb3 Casp3 Arhgef1 Rela BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Itga7 Itga8 Itga5 Itga6 Itga9 Itga4 Itga1 Itga2 Col18a1 Itga10 Itga11 Itgav Itgb1 Vtn Spp1 Fgg Mdk Jam2 Cd81 Plau Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Fbn1 Npnt Nid1 Cspg4 Col1a2 Plaur Lama4 Fgb Fga Tgfbi Lamb2 Lamb3 Lama2 Lamb1 Lamc2 Vegfa Tnc Col11a1 Col11a2 Fn1 Tgm2 Col2a1 Lamc1 Col3a1 F13a1 Col1a1 Lama1 Col6a1 Col5a2 Lama3 Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Itga3 Lama5 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Fga Src Itga5 Itgam Elane Egfr Itgav Vtn Pdgfrb Itgb1 Crk Bcar1 Itgb2 Rac1 Fgg Mmp3 Dock1 Fn1 Mmp9 Plau Itgb3 Tgfb1 Hgf Lrp1 Ctsg Pdgfd Fpr1 Klk4 Itga3 Fpr2 Itgb5 Gpld1 Fpr-s1 Plaur Mmp12 Ctrc Plg Mmp13 Serpine1 Vldlr Fgb VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Cdkn1b Lgals1 Itga6 Spi1 Hdac3 Itgb1 Ptpa Itgb4 Myc Hdac1 Cdkn2b Wnt5a Foxo3 Creb1 Id2 Col1a2 Rbl1 Tmeff2 Gfi1 Aldh9a1 Clu Fth1 Tmem126a Sfrp1 Dkk1 Max Tbp Ep300 Bcl2 Csde1 Tsc2 Hmgcs2 Nfyb Cebpd Nfya Nfyc Cebpa Zfp36l1 Sp1 Dnmt3a Gtf2h2 Slc11a1 Sfxn3 Ndrg1 Ndrg2 Tjp2 Mxd4 Pdgfrb Brca1 Smad2 Smad3 Ccl5 Smad4 Zbtb17 Cdkn1a Dntt Erbb2 Ccnd1 Ddit3 Cflar Gadd45a Irf8 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Nrg1 Erbb2 Erbb4 Egfr Hbegf Ereg Nrg2 Areg Btc Nrg4 Nrg3 Tgfa Erbb3 Egf Hsp90aa1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Gng2 Gnb1 Grk2 Tuba1b Ranbp2 Hdac4 Ube2i Tubb2a Ran Ankra2 Hdac3 Hdac5 Bcor Hdac7 Esr1 Rfxank Hdac6 Hdac9 Mef2c Camk4 Ywhae Gata2 Ywhab Ncor2 Hdac11 Hdac10 Srf Bcl6 Hsp90aa1 Nr3c1 Gata1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Wwp1 Fkbp1a Pml Xiap Eif2a Smurf1 Daxx Tgfb1 Tgfb3 Ppp2ca Arrb2 Ppp1ca Cav1 Ctnnb1 Map3k7 Ccn2 Pard6a Tgfbr1 Tgfbr2 Shc1 Grb2 Sos1 Dynlrb1 Tgfbrap1 Nedd4l Zfyve16 Ppp2cb Smad2 Smurf2 Smad3 Strap Tab2 Dab2 Smad4 Tab1 Dact2 Tgfbr3 Sptbn1 Ppp2r2a Ywhae Rnf111 Pdpk1 Ppp1r15a Camk2a Zfyve9 Bambi Smad7 Yap1 Itch Axin1 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Cdh1 Itgb7 Itgae JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Jun Crkl Dbnl Lcp2 Prkcb Map3k8 Grap2 Mapk8 Map3k7 Map4k1 Crk Map2k4 Lat Map3k1 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Ep300 Bcl2 Chp1 Rcan2 Fkbp1a Prkcg Prkcb Prkaca Prkce Mef2d Nr4a1 Cabin1 Csnk1a1 Ran Mapk8 Akap5 Nfatc1 Prkca Mapk3 Nfatc3 Nfatc2 Crebbp Bax Prkch Camk4 Bcl2l1 Ywhah Ywhag Map3k1 Ywhae Ywhab Fkbp8 Nup214 Map3k8 Sfn Bad Gsk3b Prkcd Kpnb1 Ywhaz Mapk9 Mapk14 Pim1 Casp3 Prkcq Prkcz Rcan1 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Inpp5d Map3k14 Ptpn6 Akt1 Cbl Vav1 Pten Itk Prkcq Gab2 Shc1 Lck Traf6 Lcp2 Ptpn11 Nck1 Rap1a Grap2 Trpv6 Map4k1 Grb2 Prkca Sos1 Csk Hras Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Flna Ptprc Dbnl Map3k8 Sla2 Orai1 Stim1 Stk39 Plcg1 Rassf5 Cd3e Was Fyb1 Ikbkb Sh3bp2 Cd4 H2-Eb1 Ikbkg Cd3g Cd247 Cd3d Cd28 Cd86 Cd80 Kras VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Prkcb Ptpn11 Prkaca Pik3r1 Nck1 Mapk1 Flt1 Prkca Shc2 Mapk3 Vegfa Nos3 Nrp1 Nrp2 Pdpk1 Pgf Vegfb Cd2ap Akt1 Cbl Hif1a Plcg1 Cav1 Pik3ca Hsp90aa1 Rasa1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Ednra Grb2 Sos1 Edn1 Hras Egf Mtor Egfr Shc1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Gng2 Lgals3 Gli2 Shh Prkaca Gnb1 Smo Ptch1 Csnk1a1 Pias1 Gnai1 Csnk1g3 Csnk1g1 Gnai3 Csnk1g2 Rbbp4 Rbbp7 Crebbp Sin3a Gnaz Sin3b Gnao1 Gnai2 Csnk1d Csnk1e Hdac2 Map2k1 Foxa2 Hdac1 Akt1 Arrb2 Fbxw11 Gsk3b Prkcd Sap30 Rab23 Gli1 Gli3 Mtss1 Ift88 Kif3a Sap18b Stk36 Ift172 Sufu Btrc Spop INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Irs1 Exoc1 Exoc2 Grb10 Eif4ebp1 Ptpn11 Exoc7 Pik3r1 F2rl2 Ins2 Nck1 Rhoq Trip10 Dok1 Prkci Sh2b2 Insr Grb2 Ptpn1 Sos1 Crk Hras Sgk1 Ptpra Pdpk1 Nck2 Inpp5d Akt1 Cbl Foxo3 Akt2 Cav1 Grb14 Pard6a Pik3ca Sorbs1 Exoc3 Exoc4 Rapgef1 Exoc5 Shc1 Prkcz Exoc6 Rasa1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfd Pdgfa Pdgfrb Pdgfb Pdgfc Pdgfra EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Src Pak1 Inppl1 Epha2 Pik3r1 Vav2 Cbl Ptk2 Grb2 Tiam1 Rhoa Bcar1 Rac1 Arhgap35 Pik3ca Vav3 Acp1 Shc1 Efna1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Stat3 Stat1 Pik3r1 Mapk8 Sh2d2a Mapk1 Mapk3 Brk1 Ksr1 Map2k4 Baiap2 Rac1 Arpc1b Actr2 Pld1 Actr3 Pld2 Arpc3 Map3k1 Arpc2 Arpc5 Arpc4 Ppp2ca Srf Slc9a1 Smad1 Ppp2r1a Src F2rl2 Gab1 Capn2 Usp6nl Grb2 Prkca Sos1 Hras Ywhah Ppp2r2a Ywhag Ywhae Pdpk1 Ywhab Braf Sfn Elk1 Egr1 Bad Prkcd Ywhaz Mapk9 Dusp1 Mapk7 Zfp36 Kras Map3k2 Prkcz Mylpf Ralgds Jun Arf4 Ppp5c Diaph3 Nras Map2k5 Dusp6 Fos Vav2 Rab5a Rin1 Pebp1 Rps6ka4 Rps6ka5 Atf2 Bcl2l1 Wasl Eps8 Akt1 Mtor Creb1 Iqgap1 Rala Egfr Raf1 Egf Mef2c Map2k2 Map2k1 Rictor Mapkap1 Mlst8 Nckap1 Pik3cb Wasf2 Pik3ca Cyfip2 Rps6ka3 Abi1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Ywhae Ppp2r5d Clip1 Katna1 Pafah1b3 Lrpap1 Pafah1b2 Pafah1b1 Cdk5r2 Dab1 Dync1h1 Cdk5 Cdk5r1 Ndel1 Reln Dcx Pla2g7 Rhoa Iqgap1 Abl1 Rac1 Nudc Vldlr Map1b SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Src Cdkn1a Egr1 Tuba1b Itga1 Ccna2 Rock1 Mapk1 Ptp4a3 Mapk3 Agt Itgb1 Ptp4a2 Rhoc Rhoa Bcar1 Rabggta Rabggtb Rac1 Atf5 Cdk2 Ccne1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Lck Src Ptpn13 Pik3r1 Mapk8 Itga2b Map2k4 Rac1 Blk Rgs3 Fyn Yes1 Ephb1 Ephb2 Itgb3 Ephb4 Nck2 Lyn Efnb1 Efnb2 Fgr Hck Dnm1 Map3k7 Tiam1 Pik3ca VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Mapk11 Itga5 Pik3r1 Itga4 Itga1 Itga2 Mapk1 Grb2 Mapk3 Itgb1 Sos1 Crk Map2k4 Vegfd Fn1 Vegfc Flt4 Col1a1 Akt1 Creb1 Col1a2 Mapk14 Rps6ka1 Pik3ca Shc1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Src Pxn Arrb1 Git1 Epha2 Nck1 Egfr Arf6 Itga2b Gulp1 Fbxo8 Egf Ipcef1 Cyth2 Acap2 Kif13b Gna11 Cyth3 Lhcgr Iqsec1 Gna15 Arap2 Gna14 Itgb3 Gnaq Adap1 Hgf Arrb2 Tshr Agtr1a Met Adrb2 Acap1 Efna1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Mapk11 Trp63 Pml Mdm2 Jag2 Plk3 Bax Jak1 Pin1 Sirt1 Casp2 Prkacb Pfdn5 Fbxo45 Tuba1a Ccne2 Myc Bub1 Pea15 Il1rap Clca2 Ndufs2 Hagh Plk1 Gramd4 Foxo3 Aen Dcp1b Trp73 Rnf43 Dedd Mapk14 Flot2 Afp Hsf1 Wt1 Bak1 Bub3 Cdk1 Nsg1 Il4ra Gdf15 Serpine1 Plpp1 Ep300 Bin1 Sp1 Rad51 Bcl2l11 Nedd4l Chek1 Abl1 Cdk6 Serpina1d Ada Ntrk1 Cdk2 Rack1 Cdkn1a Sfn Wwox Ccna2 Brca2 Kat5 Hey2 Yap1 Rb1 Itch Rchy1 Fasn Fas Rela Gata1 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Src Gng2 Mapk11 Arrb1 Nras Gnb1 Pik3r1 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Gnaz Gnao1 Gnai2 Map2k2 Map2k1 Pdpk1 Akt1 Rictor Dnm1 Mtor Ccl11 Mapk14 Mapkap1 Cxcl9 Map2k6 Mlst8 Pik3cb Cxcl11 Pik3ca Cxcl10 Cxcr3 Map2k3 Pf4 Cxcl13 Kras IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Stat5a Cebpb Ptpn11 Prkaca Pik3r1 Grb2 Csf2rb2 Cish Bcl2l1 Ywhag Prkacb Inpp5d Hdac1 Id1 Ywhaz Pim1 Stat5b Jak2 Pik3ca Osm Il3ra Shc1 Cnksr1 Gab2 Srp9 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Gng2 Mapk11 Prkcg Prkcb Prkaca Gnb1 Prkce Grk2 Rhoa Rac1 Blk Plcb2 Fyn Syk Prkch Yes1 Lyn Vcam1 Gna13 Akt1 Fgr Hck Pik3cg Pik3r6 Arrb2 Arr3 Mapk14 Icam1 Gnb5 Rab11a Prkcq Ptgdr Lck Ptgir Src Tbxa2r Prkg1 Egfr Prkca Nherf1 Gna12 Nos3 Egf Gnai2 Tgm2 Gna11 Gna15 Gna14 Gnaq Dnm1 Rock1 Prkcd Sele Arhgef1 Prkcz Grk3 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Col17a1 Cd9 Itga6 Pmp22 Il1a Pik3r1 Egfr Lamb2 Lamb3 Lama2 Grb2 Lamb1 Prkca Itgb1 Lamc2 Mst1 Itgb4 Hras Rac1 Erbb3 Casp7 Egf Ywhah Ywhag Lamc1 Ywhae Ywhab Lama1 Lama3 Akt1 Sfn Erbb2 Rxrb Rxra Rxrg Ywhaz Cdh1 Lama5 Met Mst1r Pik3ca Lama4 Shc1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Nras Clip1 Eif4ebp1 Srebf1 Pml Mapk1 Eif4e Mapk3 Pld1 Pld2 Akt1 Mtor Fbxw11 Btrc Eif4a1 Ccne1 Irs1 Tsc2 Prr5 Rraga Ddit4 Rragb Rragc Rragd Tsc1 Eif4b Raf1 Ulk1 Ulk2 Rb1cc1 Rrn3 Prkca Poldip3 Pdcd4 Atg13 Eef2 Hras Sgk1 Map2k2 Ywhah Cdk2 Ywhag Map2k1 Ywhae Pdpk1 Ywhab Braf Sfn Rictor Rptor Ikbkb Ywhaz Mapkap1 Rps6ka1 Mlst8 Deptor Akt1s1 Eef2k Yy1 Kras Ppargc1a ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Chuk Nfkb1 Map3k14 Btrc Nfkb2 Relb DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Nlrc4 E2f2 Prdm1 Prkab1 Ppm1j Ctsd Trp63 Col18a1 Mdm2 Pml Plk3 Mcl1 Spp1 Bax Pou4f1 Edn2 Trrap Pou4f2 Mmp2 Cd82 Taf9 Cav1 Hspa1a Tgfa Pten E2f3 Tsc2 Nfyb Nfya Nfyc Pcna Ndrg1 Snai2 Apc Trp53 Sfn Hgf Bcl2a1d Serpinb5 Carm1 Bdkrb2 Met Igfbp3 Gadd45a Dusp5 Rchy1 Dusp1 Jun Epha2 Perp Cse1l Apaf1 Ccng1 Pidd1 Cop1 Bcl2l1 Hdac2 Casp1 Foxa1 Tfdp1 Trp73 Lif Afp Bcl6 Bak1 Gdf15 Serpine1 Atf3 Dkk1 Bcl2 Ep300 E2f1 Vcan Ddit4 Sp1 Egfr Kat2a Vdr Casp6 Drosha Crebbp Ccnk Pcbp4 Tap1 Hic1 Ppp1r13b Msh2 Tyrp1 Tnfrsf10b Sh2d1a Sesn1 Map4k4 Rgcc Steap3 Cdkn1a Jmy Fdxr Ddx5 Trp53bp2 Btg2 Rrm2b Ddb2 Prmt1 Bcl2l14 Rps27l Gpx1 Bcl2l2 Bnip3l Rnf144b Trp53inp1 Triap1 Irf5 Aifm2 Rb1 Dgcr8 Htt Scn3b Bid Zfp385a Arid3a Smarca4 Pms2 Cx3cl1 Pycard Mlh1 Fas Tigar Cebpz LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkaca Prkce Lpar4 Creb1 Adcy3 Adcy7 Adcy4 Adcy1 Rps6ka5 Adcy2 Adcy8 Adcy5 Adcy6 Adcy9 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Src Nme1 Snx1 Adam10 Dnm2 Bdnf Slit1 Gdnf Cbll1 Gfra1 Dsp Cables1 Ctnnd1 Rab5a Mep1b Igf2 Egfr Robo1 Arf6 Cdh2 Zbtb33 Hgs Ptpn1 Hras Crebbp Abl1 Rac1 Mmp3 Gna12 Fyn Egf Ntrk2 Rab7 Mmp7 Igf1r Gna13 Ptpn6 Ctnnb1 Cdh1 Tiam1 Rin2 Iqgap1 Met Jup Casp3 Ret Ctnna1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Nfkbia Ppp2r5d Git1 Birc5 Prkaca Mdm2 Aurkaip1 Ran Oaz1 Tacc1 Cpeb1 Ndel1 Aurkb Trp53 Dlgap5 Ajuba Tdrd7 Brca1 Fzr1 Pak1 Tacc3 Akt1 Gsk3b Tpx2 Ckap5 Gadd45a Aurka Arhgef7 Cenpa Cdc25b Rasa1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Cblb Nfkbia Mapk10 Traf6 Jun Stat5a Mapk11 Pik3r1 Il4 Mapk8 Cd40lg Traf2 Fcamr Traf3 Cd40 Map2k4 Tdp2 Tnfaip3 Jak3 Bcl2l1 Map3k1 Myc Map3k14 Akt1 Pik3cg Pik3r6 Birc3 Mapk9 Birc2 Mapk14 Nfkb1 Pik3cb Pik3ca Traf1 Rela VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network C3 Ncoa2 Ncoa1 Nr0b1 Ncoa3 Esr2 Smarce1 Ube2m Uba3 Nedd8 Smarcb1 Zfp709 Ddx54 Smarca4 Nr0b2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurka Aurkb LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Mark2 Tsc2 Ctsd Prkaca Tsc1 Trp53 Esr1 Stk11ip Stk26 Mark4 Smad4 Crtc2 Stradb Ywhah Smarcd3 Ywhag Strada Ywhae Cab39 Etv4 Stk11 Ywhab Sik3 Myc Sik2 Sik1 Psen2 Sfn Brsk2 Brsk1 Mtor Gsk3b Rptor Creb1 Cdc37 Ywhaz Mlst8 Akt1s1 Hsp90aa1 Ezr EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb3 Ephb4 Efnb1 Efnb2 Ephb1 Ephb2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Map2k5 Nras Fos Rap1a Cdk5 Raf1 Mapkapk2 Cdk5r1 Mapk1 Ntf3 Mapk3 Rps6ka5 Hras Rit1 Rit2 Mef2c Ehd4 Map2k1 Trpv1 Braf Rap1b Elk1 Egr1 Srf Creb1 Prkcd Mapk14 Map2k6 Rps6ka1 Map2k3 Mapk7 Kras Map3k2 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Map3k3 Stat1 Nsmaf Madd Tnfrsf1a Sqstm1 Bag4 Tradd Prkci Traf2 Txn Tnfaip3 Tab2 Smpd2 Tab1 Map3k1 Map4k4 Rack1 Chuk Nrk Map4k5 Map3k5 Map4k3 Tnf Tnfrsf1b Birc3 Adam17 Cav1 Cyld Ikbkb Map4k2 Birc2 Map3k7 Rffl Ikbkg Tnik Map2k7 Nfkb1 Casp8 Smpd1 Map2k3 Traf1 Ripk1 Prkcz Rela Fadd FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Foxf1 Abcc8 Kcnj11 Cebpb Alb Apoa1 Cebpd Hnf1a Cpt1b Cebpa Cpt1c Ins2 Sp1 Hadh Dlk1 G6pc1 Hnf4a Foxa1 Foxa2 Foxa3 Akt1 Creb1 Pklr Tat Afp Aldob Nkx2-1 Acadvl Alas1 F2 Ttr Tfrc Igfbp1 Ucp2 Slc2a2 Pck1 Nf1 Pdx1 Acadm Gck Nr3c1 Cpt1a Bdh1 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Jun Diaph3 Rasgrf1 Pik3r1 Prkce Vav2 Mapk8 Mapk1 Mapk3 Arhgdia Bcar1 Map2k4 Baiap2 Atf2 Rac1 Iqgap3 Arpc1b Actr2 Pld1 Actr3 Yes1 Pak2 Arpc3 Map3k1 Wasl Arpc2 Pak1 Arpc5 Arpc4 Map3k11 Eps8 Cbl Mtor Ctnnb1 Mapk14 Cdh1 Pard6a Iqgap1 Cfl1 Map2k3 Myl2 Ctnna1 Limk1 Arhgef7 Limk2 Arhgef6 Src Exoc7 F2rl2 Cdc42bpa Septin2 Pax6 Hes5 Raf1 Tnk2 Apc Hras Braf Gsk3b Mapk9 Map2k7 Map2k6 Tiam1 Pak4 Pik3ca Dlg1 Prkcz CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Gng2 Stat5a Stat3 Stat1 Pik3r1 Gnb1 Cxcl12 Grk2 Hgs Rhoa Bcar1 Rac1 Blk Plcb2 Fyn Yes1 Ptk2b Mmp9 Pak1 Lyn Inpp5d Gna13 Ptpn6 Akt1 Fgr Hck Pik3cg Pik3r6 Mtor Arrb2 Vav1 Foxo1 Arr3 Stat5b Cfl1 Limk1 Lck Src Pxn Ptpn11 Cxcr4 Gnai1 Ptk2 Rgs1 Gnai3 Ubqln1 Vps4a Vps4b Grk6 Stat2 Rhoc Ralb Crk Csk Rhob Pag1 Gnaz Gnao1 Gnai2 Pdpk1 Rack1 Ptprc Rap1b Rictor Dnm1 Bad Cd3e Cd4 H2-Eb1 Ssh1 Mapkap1 Mlst8 Cd3g Cd247 Cd3d Jak2 Itch Pik3cb Pik3ca Plcb3 Plcb1 Prkcz P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Ywhae Tcf3 Mapk11 Tsc2 Ywhab Sfn Hspb1 Mapkapk3 Creb1 Srf Raf1 Mapkapk2 Ywhaz Mapk14 Etv1 Lsp1 Cdc25b Ywhah Th Ywhag PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Dkk1 Ppp2r5d Jun Adam10 Psen1 Ppard Hnf1a Nlk Fos Dtx1 Dll1 Csnk1a1 Wnt1 Apc Mapk1 Mapk3 Nkd1 Dkk2 Crebbp Frat1 Tab1 Ctbp1 Myc Hdac1 Dvl1 Lrp6 Ccnd1 Wif1 Fbxw11 Gsk3b Ctnnb1 Map3k7 Fzd1 Tle1 Kremen2 Tle5 Btrc Rbpj Axin1 Ncstn Notch1 Aph1b VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Ep300 Wwp1 Mfge8 Shh Sp1 Cables1 Perp Trp63 Pml Mdm2 Jag1 Vdr Itgb4 Hbp1 Abl1 Bax Dhrs3 Traf4 Ogg1 Spata18 Tfap2c Nqo1 Ada Smarcd3 Evpl Ssrp1 Dicer1 Cdkn1a Chuk Fdxr Clca2 Plk1 Aen Serpinb5 Prkcd Ikbkb Flot2 Egr2 Itga3 Igfbp3 Cdkn2a Gadd45a Itch Gdf15 Btrc Fas Gpx2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Ep300 Cebpb Crkl Il1b Stat3 Stat1 Ptpn11 Pik3r1 Rap1a Pias1 Ifng Socs1 Mapk1 Ptpn2 Mapk3 Ifngr1 Crebbp Jak1 Casp1 Map3k1 Map2k1 Pias4 Dapk1 Ptges2 Camk2a Irf9 Smad7 Map3k11 Akt1 Rap1b Cbl Camk2d Mtor Prkcd Camk2g Jak2 Pik3ca Camk2b Irf1 Rapgef1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Ap2m1 Gbf1 Pip5k1a Uso1 Kdelr1 Gga3 Ap2a1 Asap1 Arfip2 Gosr2 Cltb Arfgap1 Copa Cd4 Clta Rac1 Arf1 Cyth2 Pld2 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Traf6 Jun Myd88 Il1r1 Il1b Map3k3 Irak4 Il1a Pik3r1 Sqstm1 Prkci Mapk8 Tab2 Tab1 Casp1 Chuk Il1rap Ube2v1 Ikbkb Ticam2 Map3k7 Irak3 Ikbkg Erc1 Tollip Map2k6 Il1r2 Il1rn Nfkb1 Ube2n Pik3ca Irak1 Prkcz Rela GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Krt14 Mapk10 Jun Stat5a Mapk11 Ppp5c Pomc Krt5 Stat1 Prkaca Fos Nr4a1 Il2 Il4 Mdm2 Pou2f1 Ifng Cdk5 Cdk5r1 Mapk8 Mapk1 Spi1 Nfatc1 Csf2 Mapk3 Fgg Bax Hdac2 Prkacb Hdac1 Akt1 Creb1 Mapk14 Afp Stat5b Icam1 Gata3 Hsp90aa1 Nr3c1 Tbp Ep300 Ncoa2 Ncoa1 Il5 Prl Csn2 Trp53 Crebbp Sgk1 Ywhah Cdkn1a Sfn Egr1 Gsk3b Il6 Mapk9 Il13 Mmp1a Nr1i3 Nfkb1 Tsg101 Kmt5b Smarcc1 Fkbp5 Sele Vipr1 Tbx21 Pou1f1 Smarca4 Smarcd1 Irf1 Cga Fkbp4 Pck2 Krt17 Rela Pbx1 Smarcc2 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Stambp Cblb Src Amph Sh3gl2 Chmp3 Epn1 Nras Zfyve28 Pik3r1 Rab5a Egfr Ptk2 Raf1 Hgs Grb2 Sos1 Ube2d3 Ube2d1 Hras Spry2 Egf Usp8 Synj1 Cbl Dnm1 Itsn1 Lrig1 Sh3kbp1 Eps15 Tsg101 Pik3cb Pik3ca Arhgef7 Kras Shc1 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Cdkn1b E2f2 Uxt Ces1d Tfdp2 Cdkn2c Cbx5 Tyms Mybl2 Sult2a1 Ranbp1 Ccnd3 Mcm3 Ces2h Ces4a Pola1 Prmt5 Dhfr Apaf1 Rybp Orc1 Ces3b Mcl1 Rrm1 Hbp1 Ces5a Rrm2 E2f6 E2f7 Trrap Casp7 Wasf1 Sirt1 Cdc6 Plau Ccne2 Myc Hdac1 Cdc25a Tfdp1 Trp73 Tfe3 Rbl1 Cdkn2a Cdk1 Serpine1 Xrcc1 E2f3 Ccne1 Smarca2 Tk1 Ep300 E2f1 Trim28 Cebpa Sp1 Kat2b Kat2a Topbp1 Rbbp4 Brca1 Crebbp Atm Rbl2 Hic1 Cdk2 E2f4 Cdkn1a E2f5 Ccna2 Rb1 Rbbp8 Yy1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Nfkbia Ripk2 Traf6 Bcl10 Chuk Tnf Tnfrsf1a Cyld Ran Ikbkb Birc2 Ikbkg Erc1 Prkca Ube2d3 Nfkb1 Atm Tnfaip3 Btrc Nod2 Rela Malt1 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Epha5 Fyn Efna5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Map3k14 Ptpn6 Akt1 Cbl Vav1 Prkcq B2m Shc1 Lck Traf6 Lcp2 Cd8a Cd8b1 Rap1a Grap2 Trpv6 Grb2 Prkca Sos1 Csk Hras H2-Q10 Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Ptprc Map3k8 Orai1 Stim1 Plcg1 Rassf5 Cd3e Ikbkb Ikbkg Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Kras REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Cdkn1b Jun Ube3a Fos Il2 Ifng Mapk1 Smg5 Mapk3 Sin3a Sin3b Terf1 Smg6 Tinf2 Parp2 Hdac2 Tnks Dkc1 Pot1 Pif1 Wrn Myc Acd Hdac1 Znfx1 Tgfb1 Terf2ip Akt1 Hnrnpc Pinx1 Mtor Mxd1 Sap30 Wt1 Terf2 Sap18b Hsp90aa1 Tert Max Ifnar2 E2f1 Mre11a Nbn Sp1 Egfr Sp3 Rad50 Rbbp4 Xrcc6 Rbbp7 Esr1 Xrcc5 Blm Atm Abl1 Rad9a Smad3 Egf Nr2f2 Ywhae Hus1 Ccnd1 Rad1 Nfkb1 Irf1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Cdkn1b Jun E2f2 Mapk11 Mitf Mdm2 Ccnd3 Spi1 Hdac3 Csf2 Atf2 Smarcb1 Pparg Sirt1 Ctbp1 Hdac1 Ppp2ca Suv39h1 Tfdp1 Brd2 Pax3 Aatf Rbp2 Atf7 Mapk14 Ckm Dnmt1 Taf1 Cdkn2a Ccnd2 Ubtf E2f3 Ccne1 Myod1 Tbp Ep300 E2f1 Cebpb Elf1 Cebpd Cebpa Gsc Raf1 Runx2 Cbx4 Skp2 Rbbp4 Crebbp Abl1 Cdk6 Sftpd Mef2c Cdk4 Cdk2 E2f4 Cdkn1a Ccna2 Ccnd1 Mapk9 Rb1 Met Tgfb2 Smarca4 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Pias4 Ctdsp1 Nup214 Ube2i Kpnb1 Mapk1 Ppm1a Mapk3 Nup153 Ctdspl Tgfbrap1 Smad2 Smad3 Smad4 Map3k1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Jun Fos Cxcl12 Npm1 Ets1 Hdac7 Mcl1 Itgb2 Hnf4a Gata2 Tff3 Ldha Akt1 Hmox1 Creb1 Id2 EG433182 Plin2 Adm Tfrc Cp Igfbp1 Pfkfb3 Serpine1 Nt5e Car9 Eng Pgm1 Fech Pkm Gck Aldoa Tert Abcb1a Pfkl Ep300 Rora Hk2 Hk1 Edn1 Bhlhe41 Ncoa2 Ncoa1 Sp1 Cxcr4 Ndrg1 Cops5 Epo Bhlhe40 Vegfa Furin Crebbp Egln3 Lep Smad3 Cited2 Pgk1 Smad4 Slc2a1 Abcg2 Tf Arnt Hif1a Nos2 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Crkl Grin2a Mapk8ip1 Pik3r1 Lrpap1 Rap1a Pafah1b1 Dab1 Cdk5 Cdk5r1 Mapk8 Reln Itgb1 Fyn Map1b Nck2 Arhgef2 Map3k11 Akt1 Cbl Gsk3b Map2k7 Itga3 Grin2b Pik3ca Vldlr Rapgef1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Chuk Pik3r1 Dap3 Tnfsf10 Ikbkb Tradd Mapk8 Mapk1 Ikbkg Traf2 Mapk3 Cflar Map2k4 Pik3cb Casp8 Pik3ca Smpd1 Ripk1 Tnfrsf10b Fadd Map3k1 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Gng2 Mapk11 Gnb1 Crh Mapk9 Mapk14 Mapk8 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Src Stat5a Stat3 Stat1 Kdr Pik3r1 Eif2ak2 Ins2 Csf1r Itga1 Lman1 Gab1 Egfr Pias1 Rab4a Csf1 Insr Grb2 Stat6 Ptpn2 Ptpn1 Pdgfrb Itgb1 Sos1 Eif2a Vegfa Pdgfb Crebbp Jak3 Jak1 Egf Hgf Kpnb1 Stat5b Met Pik3cb Pik3ca Shc1 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Ctdsp1 Grem1 Ahsg Sostdc1 Rgmb Rgma Xiap Mapk1 Hjv Chrd Cer1 Fst Bmp4 Nog Bmpr1a Bmp6 Zfyve16 Ski Bmp2 Smad6 Smurf2 Tab2 Smad4 Tab1 Smurf1 Ppp1r15a Bambi Smad7 Nup214 Ppp1ca Gsk3b Map3k7 Bmpr2 Smad1 Ppm1a Smad9 Ctdspl Bmp7 Smad5 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events Gna15 Gna14 Gng2 Rock2 Gnaq Gna13 Gnb1 F2rl2 Rock1 Rhoa F2 F2rl3 Plcb2 Myl2 Gna11 FSH%NETPATH%FSH FSH Map2k2 Grk4 Fshb Fshr Akt2 Grk6 Cga Appl1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Med23 Med12 Med1 Dhh Hhip Ihh Stk36 Prkaca Ctnnb1 Gli1 Med6 Gli2 Cdk8 Ywhae Grk2 Ptch2 Sap18b Ptch1 Dyrk1a Sufu Boc Arrb2 Gas1 Kif27 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Creb1 Ar Hdac1 Hspb1 Akt1 Pik3r1 Ptk2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Runx2 Rb1 Kat2b Tgfbr3 Prkar2a Trim33 Pml Ski Map2k3 Samd3 Mef2a Mef2c Brca1 Zfyve9 E2f4 Cdkn1a Tgfbr2 Arrb2 Ar Hdac1 Akt1 Pik3r1 Ptk2 Atf2 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Ube2i Myc Sox9 Skp1 Pdk1 Pard6a Ctnna2 Ctnna1 Dcp1a Rbx1 Eid2 Ube2d3 Ube2d1 Nup153 Trp73 Sik1 Btrc Cdc25a Atf3 Jund Pxn Sdc2 Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Pik3ca Ccnd1 Vdr Trp53 Cav1 Sptbn1 Esr1 Ppp2r2a Stk11 Hspa8 Map4k1 Ppp1r15a Nup214 Wwtr1 Sparc Cdk6 Smad4 Fnta Cdk4 Cul1 Cdc16 Tab1 Junb Daxx Smad6 Hnf4a Ing2 Xpo1 Xpo4 Pdpk1 Ctcf Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Gsk3b Rbl2 Zeb2 Anapc10 Smurf1 Crk Pik3r2 Eng Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Prkar1b Nfyc Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Fosb Runx3 Cd44 TCR%NETPATH%TCR TCR Map2k2 Ctnnb1 Dyrk1a Creb1 Akt1 Pik3r1 Ptk2 Atf2 Mapk1 Mapk3 Pxn Gsk3b Crk Pik3r2 Pard3 Prkd1 Prkd2 Eno2 Crkl Cd2ap Acta1 Plcg1 Cblb Plcg2 Ly9 Wipf1 Prkcd Itsn2 Rasgrp1 Rasgrp2 Vasp Arhgef7 Arhgef6 Rasa1 Txk Arhgef2 Unc119 Cabin1 Pttg1ip Pik3ap1 Bcl10 Grap Lnpep Pag1 Lyn Egr1 Nfkbib Fyb1 Tfrc Pik3c2b Cgn Homer3 Nfkbia Crebbp Kirrel1 Slamf6 Cyfip1 Grb2 Ada Ikbkb Itk Gdi2 Shb Tsg101 Dyrk1b Cltc Cd28 Nfkb1 Pgam1 Jak3 Ptprh Vav3 Rap1a Diaph1 Syk Skap2 Skap1 Gab2 Vav1 Vav2 Card11 Bdh1 Ldha Ldhb Tuba4a Prpf4b Icos Zdhhc17 Golga5 Ctla4 Was Cd3g Actr10 Cd3e Cd3d Dusp3 Def6 Pak1 Nfam1 Caskin2 Cct8 Dpysl2 Git2 Ahcy Grap2 Elp3 Mpzl1 Map2k1 Rapgef1 Hnrnph3 Nedd9 Stat1 Dbnl Mapk7 Sh2d3c Mapk8 Tuba1a Sla Map3k8 R3hcc1l Sit1 Dgka Erbin Cd86 Sdcbp Cd84 Sh2d2a Cd82 Cd80 Snrnp70 Lax1 Hsp90ab1 Rela Mtmr10 Dok1 Dok2 Hgs Fcrl5 Stk39 Pkp4 Flnb Anxa2 Raf1 Inpp5d Shc1 Pi4ka Stk4 Acly Ripk2 Elmo1 Abl1 Bmf Ptprc Tubb5 Ppp3cb Eprs1 Ptpra Pstpip1 Acbd6 Fer Ogn Cdk1 Lat Itpr1 Zap70 Wdr1 Arhgdib Ddx3x Txnrd1 Pecam1 Nfatc1 Hdac7 Acp1 Pgm1 Nck1 Nfatc2 Stam2 Anxa11 Msl2 Adam9 Dnm2 Epha3 Ddx49 Pkm Lck Evl Sos2 Lcp2 Sos1 Lpxn Ywhaz Eif3m Ubash3b Atp1a1 Src Atp1a3 Ptpn6 Trim25 Cbl Cebpb Dock2 Cd2 Muc1 Cd4 Trat1 Cd5 G6pdx Cd7 Ptpn11 Ptpn12 Mapk14 Arhgap35 Dnajb1 Ptk2b Sh2b3 Sh3bp2 Tec Khdrbs1 Ptpn22 Chuk Ran Mapk11 LEPTIN%NETPATH%LEPTIN Leptin Runx2 Esr1 Akt1 Src Ptk2 Jak3 Mapk1 Shc1 Plcg1 Plcg2 Khdrbs1 Chuk Crp Erbb2 Irs1 Irs4 Eif4ebp1 Pde3a Socs7 Gsk3b Prkaa1 Prkaa2 Gnaq Slc2a4 Fyn Jak1 Nos3 Cfl2 Sh2b1 Egfr Eif4e Stat1 Gsk3a Cdk5 Itgb5 Mapk8 Lep Nfkbia Limk1 Prkce Rps6ka2 Acacb Ncoa1 Igf1r Grb2 Ikbkb KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Matk Socs6 Ptpru Gys1 Akt1 Jak2 Sh3kbp1 Pik3r1 Mad2l1 Atf2 Rela Fgr Hck Prkcb Rps6ka1 Mapk1 Kit Tnfrsf10b Prkca Il7r Spred1 Ezr Raf1 Spred2 Inpp5d Grb7 Ep300 Mtor Crkl Epor Csf2rb2 Mapk12 Yes1 Cblb Abl1 Kitlg Rdx Msn Wipf1 Stat5a Stat5b Fes Cdk2 Hras Rasa1 Grap Jun Pik3ca Sos1 Cltc Src Jak3 Ptpn11 Mapk14 Tec Was Eif4ebp1 Gsk3b Crk Fyn Stat1 Mapk8 Socs1 Mitf Socs5 Socs4 BCR%NETPATH%BCR BCR Rb1 Hck Prkcb Rps6ka1 Prkd1 Crkl Plcg1 Prkcd Cdk2 Cd72 Stap1 Elk1 Sla2 Rasa1 Chst15 Malt1 Prkcq Gtf2i Tcl1 Rasgrp3 Btk Bcl10 Pip4k2b Pip4k2c Pip4k2a Cd79a Lyn Cd79b Pik3cg Cdk7 Bcl6 Btla Hnrnpk Itpr2 Bank1 Nfatc3 Cd22 Plekha2 Plekha1 Grb2 Hcls1 Lat2 Ikbkb Blnk Itk Ptpn18 Ccl4 Casp7 Mapkapk2 Casp9 Sh2b2 Fcgr2b Bax Stat3 Pip5k1c Pip5k1b Pip5k1a Vav1 Card11 Rapgef1 Ctnnb1 Nedd9 Stat1 Creb1 Akt1 Ptk2 Atf2 Rela Dok1 Mapk1 Shc1 Itpr1 Zap70 Nck1 Nfatc2 Jun Lck Sos2 Sos1 Map4k1 Ptpn6 Junb Mapk14 Pdpk1 Sh3bp2 Tec Foxo3 Chuk Fos Eif4ebp1 Gsk3b Crk Fyn Pik3r2 Gsk3a Bcar1 Fosb TNFALPHA%NETPATH%TNFALPHA TNFalpha Prkca Ep300 Stat5a Gtf2i Casp7 Mapkapk2 Bax Nkiras1 Rpl4 Nkiras2 Erbb3 Tbkbp1 Trib3 Rps11 Tbk1 Tnfrsf11a Dpf2 Kcnq1 Tax1bp1 Polr1b Polr1c Txnip Polr1a Polr1d Polr1e Actl6a Smarce1 Tifa Cdc37 Cdc34 Rffl Rasa3 Akt2 Nfkbiz Txn Glg1 Sec16a Cradd Dcaf7 Nfkbie Diablo Rel Faf1 Ikbkg Tnfrsf8 Ikbke Mark2 Tnfrsf1b Rfk Akap8 Psmb5 Ywhae Gab1 Bcl2l1 Rack1 Fkbp5 Fbxw7 Fadd Smpd3 Psmc2 Psmc1 Psmc3 Map2k5 Creb1 Itch Bid Hdac1 Commd1 Hspb1 Akt1 Trpc4ap Psmd7 Ptk2 Psmd6 Fancd2 Psmd3 Psmd2 Elp1 Psmd1 Mapk1 Ktn1 Pkn1 Map3k11 Lrpprc Mapk9 Brinp1 Mapk3 Nr2c2 Nlrp4e Ube2i Tnf Map3k5 Skp1 Hsp90aa1 Pdk1 Fbl Ppp1r12a Unc5cl Ppp1r13l Usp2 Xiap Fbxw11 Txlna Ube2d3 Tank Relb Map3k3 Map3k2 Btrc Rxra Flna Papola Bag4 Ripk3 G3bp2 Cops3 Kpna6 Kpna3 Cdk9 Zbtb17 Cyba Ccnt1 Trap1 Bcl3 Tab3 Tab2 Traf7 Mcm7 Traf4 Pfdn2 Traf6 Traf5 Birc3 Jun Birc2 Ywhah Ywhag Psmd12 Copb2 Hdac2 Cav1 Smarcb1 Ywhab Psmd13 Alpl Rasal2 Rnf11 Hdac6 Iqgap2 Peg3 Bcl7a Ppp6c Nupr1 Rps6ka5 Mcm5 Smarca4 Cul1 Tnip2 Polr2h Tab1 Pdcd2 Junb Nsmaf Zfand5 Cflar Casp3 Romo1 Casp2 Trim32 Spag9 Usp11 Glb1 Smarcc2 Prc1 Smarcc1 Rnf25 Foxo1 Mtif2 Map2k6 Rb1 Pml Nfkbia Crebbp Grb2 Nfkb1 Pak1 Stat1 Mapk8 Map3k8 Hsp90ab1 Dok1 Ddx3x Sos2 Sos1 Ywhaz Src Ptpn11 Mapk14 Irs1 Egfr ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Lamc2 Ar Vim Akt1 Pik3r1 Ptk2 Mapk1 Prkca Mapk3 Shc1 Mtor Yes1 Abl1 Prkcd Trp73 Pik3cg Jun Ywhah Pik3ca Grb2 Ywhab Ywhaz Src Ptpn11 Mapk14 Casp3 Clca1 Erbb2 Rpsa Irs1 Irs2 Fos Rhoa Pak1 Rac1 Eif4ebp1 Plec Dsp Lama5 Cd151 Itgb4 Lama2 Lama3 Fyn Mst1r Pik3r2 Met Mylk3 Col17a1 Egfr Itga6 Eif4e Ntn1 Ephb2 Lamb2 Ywhae Lamb3 Gab1 Sfn Lamb1 Pik3cb Pik3cd Rtkn Bad Smad2 Erbin Smad3 Eif6 Lamc1 WNT%NETPATH%WNT Wnt Map3k7 Sox1 Ctbp1 Akt1 Wnt5a Cdh1 Setdb1 Pi4k2a Ppp1ca Prkcb Sfrp2 Ppp2ca Sfrp1 Daam1 Prkca Dkk1 Mesd Pax2 Prkcg Frzb Dixdc1 Chd7 Axin1 Ror1 Lef1 Lrp1 Yes1 Arhgef4 Csnk1a1 Nlk Lrp5 Prkcd Gpc3 Dvl3 Wnt2 Wnt1 Tcf7l2 Wnt3 Fzd1 Jup Fzd5 Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Smad1 Bcl9 Pin1 Tcf4 Nfatc2 Jun Ccnd1 Ywhab Pip5k1b Cdk6 Rhoa Rac1 Prkaca Mark2 Mapk8 Arrb2 IL6%NETPATH%IL6 IL6 Ar Rb1 Map3k7 Hdac1 Hspb1 Akt1 Pik3r1 Fgr Hck Mapk1 Mapk3 Shc1 Ep300 Hsp90aa1 Plcg1 Nlk Stat5a Prkcd Stat5b Btk Cdk9 Socs3 Lyn Map3k4 Pias3 Cd40 Tyk2 Sgk1 Il6st Hnrnpa1 Il6 Bmx Crebbp Eif2a Jun Map2k4 Il6ra Grb2 Nfkb1 Stat3 Cbl Erbb3 Gab2 Vav1 Ptpn11 Daxx Mapk14 Ptk2b Foxo4 Foxo3 Foxo1 Map2k2 Erbb2 Fos Rac1 Eif4ebp1 Gsk3b Fyn Jak1 Pik3r2 Map2k1 Eif4e Stat1 Mapk8 Gab1 Map2k6 Ncoa1 Bad TSH%NETPATH%TSH TSH Creb1 Tshr Hspa5 Canx Gnai2 Atp1a1 Gnai1 Scrib Calr Gnai3 Map2k3 Gnaq Mapk3 Raf1 Lep Map2k6 Igf1r Gna12 Gna11 Ikbkb Gna13 Gnao1 EGFR1%NETPATH%EGFR1 EGFR1 Tjp2 Cavin1 Cavin2 Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Stambp Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Ripk1 Sirpa Ralgds Dlg3 Crim1 Ddx6 Afap1l2 Tgif1 Sfpq Dapp1 Asap1 Iqgap1 Asap3 Anks1 Baiap2 Lsr Epn1 Rps6ka3 Dyrk4 Epn3 Usp31 Dyrk3 Dock4 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Rgs16 Kras Mta2 Snrpd2 Egf Spry2 Spry3 Spry1 Reps2 Spry4 Pebp1 Ptpn23 Zpr1 Map2k2 Appl1 Dyrk1a Creb1 Hdac1 Pik3r1 Ptk2 Mapk1 Myc Jund Dab2 Sp1 Jun Pik3ca Trp53 Cav1 Stk11 Pdpk1 Foxo4 Zfyve16 Foxo1 Fos Gsk3b Crk Pik3r2 Ap2b1 Map2k3 Pard3 Prkd1 Crkl Plcg1 Cblb Plcg2 Prkcd Itsn2 Vasp Arhgef7 Pttg1ip Lyn Tfrc Pik3c2b Kirrel1 Shb Dyrk1b Cltc Nfkb1 Pgam1 Vav1 Vav2 Ldha Prpf4b Pak1 Caskin2 Git2 Mpzl1 Map2k1 Nedd9 Mapk7 Mapk8 Erbin Sdcbp Rela Dok1 Dok2 Pkp4 Flnb Raf1 Abl1 Ptpra Cdk1 Ddx3x Acp1 Nck1 Adam9 Pkm Lck Ywhaz Ubash3b Atp1a1 Ptpn6 Cebpb Ptpn12 Mapk14 Arhgap35 Ptk2b Khdrbs1 Erbb2 Eif4ebp1 Prkaa1 Prkaa2 Fyn Jak1 Nos3 Sh2b1 Egfr Gsk3a Cdk5 Rps6ka2 Socs1 Jak2 Sh3kbp1 Rps6ka1 Kit Prkca Grb7 Mtor Stat5a Stat5b Cdk2 Hras Elk1 Pik3cg Ptpn18 Casp9 Erbb3 Gab1 Itch Mapk9 Map3k3 Ywhab Rps6ka5 Irs2 Rhoa Rac1 Plec Dsp Itgb4 Met Col17a1 Ephb2 Pik3cb Pik3cd Bad Smad2 Smad3 Vim Ctbp1 Cdh1 Prkcg Arhgef4 Jup Socs3 Map3k4 Pias3 Tyk2 Hnrnpa1 Scrib Il17rd Myl12b Mprip Elk4 Gja1 Tfg Ralb Otud6b Araf Frs2 Frs3 Arhgap5 Prkci S100a14 Arap1 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot1 Errfi1 Myo6 Garem1 mt-Co2 Antxr1 Arf4 Braf Clta Cyld Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl2 EG433182 Stx4 Inppl1 Pygb Pdzd11 Gsn Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Ensa Stat2 Pkn2 Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Atxn2 Grb14 Rictor Grb10 Phpt1 Stip1 Cdh3 Cdh2 Plekhn1 Cfl1 Magi1 Hat1 Pkp2 Hnrnpdl Anxa4 Ldlr Pkp3 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Serpinb3d Abl2 Slc38a2 Ptpre Tnk2 Alb Bcl2 Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Sh3gl3 Epha1 Epha2 Epha4 Itgb1 Dsg2 Ctnnal1 Cd59b Wbp2 Sri Ephb1 Cebpa Ephb3 Ephb4 Ahcyl1 Ptpn1 Slitrk6 Csk Arhgap32 Rbbp7 Tagln2 Pten Ralbp1 Bcar3 Slc25a5 Arhgap42 App Spart Nectin1 Rps10 Tns4 Scamp3 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Pfn1 Tln1 Rin1 H3c8 Hnrnpr Sdc4 Sdc3 Insr Stam Atp5f1c Usp6nl Slc5a5 Snx5 Tollip Pdcd6ip Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Ptprk Ptprf Dcbld2 Rps27l Git1 Cdv3 Laptm4a Plekha6 Plekha5 Mink1 Actn1 Actn4 Plscr1 Gprc5a Map2k7 Aldoa Ncoa3 Limd1 Cstb Krt18 Krt17 Racgap1 Wasl Cttn Axl Ctnnd1 Huwe1 ID%NETPATH%ID ID Psmd4 Map2k2 Rb1 Fhl2 Tcf7l2 Pax5 Elk1 Elk3 Rbl1 Hes1 Atf3 Id3 Smurf2 Rbl2 Tcf3 Myf5 Mapk1 Elk4 Map2k1 Mapk3 Raf1 Smad3 Cdk2 IL9%NETPATH%IL9 IL9 Mapk3 Tyk2 Kat5 Stat6 Mapk1 Stat5a Il9r Stat5b IL3%NETPATH%IL3 IL3 Creb1 Ywhab Ywhaz Pik3r1 Nfkb1 Ptk2 Ptpn6 Dok1 Prkcb Mapk1 Ppp2ca Socs2 Prkca Bcl2l11 Kcnip3 Rara Gab2 Slc2a1 Inpp5d Gata2 Shc1 Crkl Csf2rb2 Ptprc Fes Foxo1 Hras Rxra Gsk3b Crk Pik3r2 Map2k1 Socs3 Lyn Prkaca Gsk3a Gab1 Bcl2l1 Rack1 Pik3cd Bad IL5%NETPATH%IL5 IL5 Ywhaz Nfkb1 Bax Atf2 Stat3 Hck Cbl Rps6ka1 Syk Raf1 Shc1 Alox5 Ptpn11 Il2rb Pla2g4a Crkl Mapk14 Il5 Sox4 Ptk2b Il5ra Stat5a Stat5b Prkcd Foxo3 Map2k2 Hras Elk1 Unc119 Gsk3b Jak1 Lyn Rapgef1 Ctnnb1 Pik3cg Stat1 Gsk3a Nfkbia Dnm2 Rack1 Jun Socs1 Hcls1 Grb2 Sdcbp Sos1 IL4%NETPATH%IL4 IL4 Akt1 Jak2 Ptk2 Atf2 Mapk1 Ets1 Mapk3 Inpp5d Shc1 Ep300 Plcg2 Prkcd Elk1 Rasa1 Cebpa Cd40 Tyk2 Nfkbia Crebbp Pik3ca Ikbkb Nfkb1 Ptpn6 Stat3 Cbl Cebpb Syk H3c8 Ptpn11 Mapk14 Stam Spi1 Il13 Cxcr4 Il13ra1 Snd1 Il4 Chuk Grk3 Il2rg Mapk11 H3c7 Irs2 Jak1 Ncoa3 Mapk8 Pik3cd Bad Socs1 IL-7%NETPATH%IL-7 IL-7 Akt1 Pik3r1 Stat3 Jak3 Mapk1 Il7r Mapk3 Shc1 Stam Cblb Stat5a Stat5b Foxo3 Foxo1 Map2k2 Il2rg Il7 Irs1 Irs2 Gsk3b Fyn Map2k1 Stat1 Gsk3a Bad NOTCH%NETPATH%NOTCH Notch Kat2b Akt1 Jak2 Pik3r1 Rela Mapk1 Mapk3 Ep300 Skp1 Lef1 Rbx1 Smad1 App Hdac2 Src Hes1 Nfkb1 Stat3 Tcf3 Cul1 Sin3a Fhl1 Mfng Ccn3 Skp2 Gsk3b Sap30 Hes6 Maml3 Notch4 Notch2 Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Dll3 Dll4 Maml1 Ring1 Maml2 Furin Fbxw7 Jag2 Cirsr Rbpj Yy1 Smad3 Lfng IL2%NETPATH%IL2 IL2 Stat4 Creb1 Il2ra Ybx1 Ets2 Plcb1 Akt1 Tert Pik3r1 Nr3c1 Atf2 Rela Itm2b Ccne1 Eif3b Il2 Prkcz Mapk1 Nmi Vil1 Mknk1 Ets1 Mapk3 Raf1 Shc1 Mtor Crkl Hsp90aa1 Stat5a Stat5b Cdk2 Bcl2 Elk1 Socs3 Lyn Pik3cg Stam2 Sgk1 Jun Lck Pik3ca Grb2 Sos1 Shb Nfkb1 Ptpn6 Jak3 Cbl Gab2 Vav1 Ptpn11 Il2rb Mapk14 Stam Ptk2b Foxo3 Map2k2 Il2rg Irs1 Irs2 Eif4ebp1 Crk Fyn Jak1 Pik3r2 Map2k1 Eif4e Mapk8 Pik3cb Pik3cd Il15 TSLP%NETPATH%TSLP TSLP Stat4 Relb Akt1 Nfkb1 Rela Stat3 Stat6 Mapk1 Map2k1 Nfkb2 Mapk9 Mapk3 Eif4e Stat1 Mapk14 Mapk8 Nfkbia Stat5a Stat5b RANKL%NETPATH%RANKL RANKL Map3k7 Ptk2 Nfkb1 Rel Nfkb2 Traf3 Tnfsf11 Atp6v1e1 Tab1 Sqstm1 Tab2 Tnfrsf11b Trem2 Mapk14 Traf2 Mapk8 Traf1 Traf6 Traf5 Spi1 Mitf Chuk IL1%NETPATH%IL1 IL1 Rb1 Akt1 Pik3r1 Nfkb1 Atf2 Rela Map2k3 Dok1 Ppp6c Elp1 Mapk1 Mapk9 Mapk3 Tab1 Pla2g4a Mapk14 Peli1 Ube2v1 Ube2n Irak4 Irak3 Irak2 Irak1 Tollip Myd88 Chuk Il1a Fbxw5 Il1b Map3k2 Peli2 Il1r2 Il1r1 Il1rn Rel Pik3r2 Tab3 Tab2 Mapk8 Traf6 Nfkbia Map2k6 Jun Ikbkb Map3k14 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Hacl2 Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Rpia Gpi Taldo1 Hkdc1 Pgd Tkt Hk2 Hk1 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation Faah FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Mthfd2 Dhfr Mthfd1l Tyms Mtr FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Gale Galt Aldob Aldoc Aldoa Hkdc1 Khk Hk2 Hk1 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Tab1 Mapk11 Traf6 Srf Mef2d Elk1 Map3k7 Map2k6 Map3k4 Hspb1 Mapk12 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Cryaa Rac2 Kdr Akt1 Rac3 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Pik3ca INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Nos3 Il10 Ikbkb Il11 Mapk7 Spi1 Il15 Irs1 Cxcr1 Stat6 Cxcr2 Stat4 Il13 Il18 Il2ra Il2rb Irs2 Il15ra Mapk6 Sla2 Elk3 Elk4 Pdpk1 Akt3 Myc Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Il20ra Fos Il23a Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Il5ra Sos2 Sos1 Il6st Shc1 Il10rb Il3ra Mtor Il2 Il4 Srf Il6 Il5 Elk1 Il7 Il9 Il21 Il12rb1 Mapk15 Il12rb2 Spic Il1a Stat5a Mapkapk2 Stat5b Il6ra Il4ra Stat3 Stat2 Stat1 Chuk Mknk2 Cdkn1a Mknk1 Cdkn1b Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 Pik3cb Pik3ca FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis Flad1 Rfk HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Rsad1 Hmbs Fech Eprs1 Cpox Urod Ppox Ears2 Cox10 Alad Qars1 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Cacna1g Cacna1c Chrnb4 Epb41l2 Kcnk3 Chrnb3 Clic6 Ppp1r1b Chrnb2 Gng2 Slc18a2 Adcy2 Drd2 Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Gnb1 Chrna4 Flna Gnai1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Sqle Fdps Mvk Pmvk Ggps1 Hmgcr Mvd Pdss1 Fdft1 Lss IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Grm2 Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc17a8 Slc1a6 Slc17a6 Vamp8 Vamp1 Gria4 Vamp3 Vamp2 Gria3 Snap29 Gria2 Snap25 Gria1 Grik5 Snap23 Stx19 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Stx11 Grin2b Grin2a Shank1 Shank3 Grm3 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 Pnpo CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Rpa3 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Mapk13 Mapk14 Pik3c2b Pik3c2a Hras Cdkn1a Mapk11 Pik3c3 Pdpk1 Akt3 Akt1 Akt2 Ccne1 Ccng1 Ctnnb1 Trp63 Kras Rb1 Ppp2cb Nras Ppp2ca Trp53 Tpte Pten Pik3c2g Rbl1 Cdk2 Pik3r5 Siah1a Pik3r1 Atm Pik3r2 Trp73 Pik3cg Pik3cb Pik3cd Mapk12 Pik3ca THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Plcb1 Hrh1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Gng12 Itpr2 Itpr1 Gng2 Plcg1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Gnb1 Prkce Prkca Plcb4 Plcb3 Gna11 Gng10 Gna14 Prkcz Plcd1 Plcb2 Plcd4 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Grin1 Gnaq Prkaca Prkcb Itpr1 Prkar1a Prkar1b Grik5 Prkx Prkacb Grina Grm1 Grik1 Plcb4 Grm5 Homer1 Gna11 Grin2d Grin2c Grin2a Grin2b OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Map2k3 Myc Mapk13 Bcl2 Mapk14 Eef2k Map2k4 Stat1 Mef2c Mknk2 Mknk1 Mapk11 Pla2g4a Mapk9 Elk1 Jun Mapk8 Map2k6 Ddit3 Max Mapk12 Txn 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Kcnk3 Gnao1 Gng2 Adcy7 Adcy2 Prkar2a Prkar2b Htr1d Htr1f Prkaca Gnai2 Kcnk9 Htr1b Htr1a Gng11 Gnai3 Gnb1 Gnai1 Gng10 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Gng2 Plcg1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Oxtr Prkcd Gnb1 Prkce Prkca Plcb4 Plcb3 Gna11 Gng10 Gna14 Prkcz Plcd1 Plcb2 Plcd4 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Gng3 Gng2 Gng4 Adcy7 Gng7 Adcy2 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Htr4 Gnb1 Gnal Gng12 Gng10 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Prkar1a Prkar1b Prkacb Cacna1g Gnao1 Adcy7 Adcy2 Prkar2a Prkar2b Prkaca Gng11 Gnai3 Gnb1 Cacna1a Cacna1b Gnai1 Gabbr1 Gabbr2 Adcy4 Adcy1 Adcy8 Adcy5 Adcy6 Adcy9 Kcnj3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2e3 Uba3 Ube2d1 Ube2e2 Ube2e1 Ube2g2 Ube2l6 Ube2g1 Ube2a Atg7 Sae1 Ube2l3 Ube2t Ube2v2 Ube2k Uba6 Uba7 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway App Erbb4 Apbb2 Nectin1 Apbb3 Trpc6 Afdn Trpc5 Cdh3 Trpc7 Kat5 Wnt5a Cdh1 Trpc1 Trpc4 Wnt5b Wnt9a Kat7 Wnt9b Fzd10 Ctnnb1 Wnt10a Bace2 Wnt10b Bace1 Acta1 Gsk3b Acta2 Actb Actr2 Notch4 Ern1 Notch1 Notch2 Notch3 Psen1 Wnt8b Wnt8a Psen2 Fstl1 Lrp1b Wnt16 Wnt11 Lef1 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Cd44 Actg1 Tcf7l2 Wnt3 Fzd1 Actbl2 Fzd3 Actc1 Fzd2 Trim3 Jup Fzd5 Trim2 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Rbpj Wnt2b 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh1b1 Maoa Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh4a1 Aldh1a3 Aldh2 Aldh3a1 Aldh16a1 Aldh8a1 Aldh7a1 Aldh9a1 Il4i1 Aldh1l1 Aldh1l2 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm2 Mdm4 Trp73 Cop1 Trp63 Trp53 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Hacl2 Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss2 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Pank3 Pank2 Pank4 Ppcs Pank1 Dcakd METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Aco1 Ireb2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Nfkbil1 Cd22 Vav3 Syk Vav1 Map2k2 Vav2 Map3k3 Map2k1 Map3k2 Hras Blnk Ikbkb Btk Cd79a Cd79b Ptpn6 Lyn Ptprc Ppp3ca Ppp3cb Nfkbia Cd19 Grb2 Mapk10 Fos Sos2 Sos1 Mapk12 Mapk13 Mapk14 Chuk Itpr3 Itpr2 Mapk11 Itpr1 Mapk1 Mapk9 Mapk3 Jun Mapk8 Rac2 Rac1 Araf Plcg2 Nras Prkcb Prkcd Raf1 Pik3cg Pik3cb Pik3cd Pik3ca P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Akt2 Trp63 Ppp2cb Ppp2ca Trp53 Trp73 Eif4ebp1 Tsc2 Tsc1 Igbp1 Prkaa1 Prkab2 Prkaa2 Rps6kb2 Prkab1 Akt3 Akt1 Prkag1 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Liph Plcb1 Dagla Lpl Pla1a Plcb3 Plcb2 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppa Pmm2 Gmds Mpi Gmppb Pmm1 MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrnp40 Zrsr2 Prpf3 Snrpb2 Snrpa HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Akt2 Rorc Arnt Txn2 Crebbp Egln2 Egln3 Mtor Vhl Hif1a Txn Akt3 Akt1 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Polr2e Creb3l1 Polr2f Ttf2 Creb3l2 Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Gtf2h4 Psmc3ip Gtf2f2 Gtf2h3 Gtf2f1 Brf2 Tbp Brf1 Prkar1a Tbpl2 Prkar1b Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Gtf2e1 Taf4 Taf2 Gtf2e2 Prkar2a Prkar2b Crebbp Gtf2a1l Polr2c Taf1c Taf9 Ep300 Creb3l3 Polr2h Creb3l4 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Oprd1 Pomc Gnao1 Gng3 Gng2 Gng4 Adcy7 Gng7 Adcy2 Gng8 Gngt2 Gnai2 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 Gnb1 Gng12 Gnai1 Gng10 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b10 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 Glul UNTITLED%PANTHER PATHWAY%P00019 untitled Nos3 Map2k2 Map2k1 Akt3 Akt2 Plcb4 Plcb3 Gna11 Gna14 Plcb2 Plcb1 Gnaq Itpr3 Itpr2 Itpr1 Prkar1a Mapk1 Prkar1b Pla2g4a Prkacb Mapk3 Akt1 Adcy7 Adcy2 Araf Prkar2a Prkcq Prkar2b Prkcg Prkaca Prkch Prkci Ednrb Prkcb Ednra Adcy3 Edn1 Prkcd Edn2 Gnal Edn3 Prkce Prkca Adcy10 Raf1 Gucy1b1 Prkg2 Adcy4 Prkg1 Adcy1 Gucy1a1 Adcy8 Gucy1a2 Adcy5 Adcy6 Adcy9 Prkcz HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Gch1 Fpgs Dhfr Tyms 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Gng2 Plcg1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Gng11 Prkcd Gnb1 Prkce Prkca Plcb4 Plcb3 Gna11 Htr2a Gng10 Htr2c Gna14 Htr2b Prkcz Plcd1 Plcb2 Plcd4 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Map3k3 Map3k2 Mapk10 Map3k4 Mapk13 Map2k4 Braf Pik3c3 Mapk9 Mapk3 Mapk8 Rac2 Map2k3 Rac1 Araf Nras Raf1 Pik3r1 Pik3r2 Pxn Pik3cg Col14a1 Pik3cb Map3k5 Pik3cd Itgbl1 Pik3ca Crkl Arfgap1 Col10a1 Pik3c2b Col1a2 Pik3c2a Col5a2 Ptk2 Col5a3 Map2k2 Dmbt1 Col5a1 Map2k1 Col9a2 Hras Col9a3 Col9a1 Arpc1b Lama5 Arpc1a Lama1 Lama2 Lama3 Lama4 Flnb Tln1 Vcl Vasp Col17a1 Col13a1 Fn1 Itga7 Mapk6 Arl1 Itga8 Itga5 Itga6 Itga9 Itga3 Itga4 Elmo2 Itga1 Itga2 Elmo1 Itga10 Itga11 Col4a3 Col4a4 Arpc3 Col4a1 Cav1 Actb Arpc2 Col4a2 Col8a1 Col4a5 Sos2 Col8a2 Sos1 Col4a6 Shc1 Arpc5 Parvb Parva Rap2b Col16a1 Rap2a Arf1 Rap2c Col12a1 Itgax Ilk Itgav Rnd2 Rhoc Rnd3 Rhoa Rnd1 Rhob Itgam Asap1 Itgae Itgal Arhgap10 Rap1a Col3a1 Rap1b Itgad Itgb8 Itgb6 Itgb7 Actg1 Itgb1 Itga2b Itgb4 Rras Actn2 Actbl2 Itgb5 Itgb2 Actn1 Col20a1 Actn4 Crk Arf6 Arpc5l Arhgap26 Col15a1 Col11a1 Col11a2 Src Ntn4 Dock1 Bcar1 Dnajc27 Lamb2 Lamb3 Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Col6a1 Col6a2 Flna Ptk2b Col6a3 Lims2 Lamc3 Rapgef1 Lamc1 Lamc2 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Arhgap9 Shc3 Rasa2 Rasa1 Vav3 Rasa4 Pdgfrb Vav1 Pdgfra Vav2 Pdgfa Map3k2 Pdgfrl Pdgfb Grap Fli1 Rps6kc1 Fev Gabpa Nck2 Jak2 Jak1 Nck1 Arhgap15 Grb2 Arhgap12 Gab1 Mapk10 Gab2 Etv3 Spdef Elf1 Elf2 Gsk3a Elf3 Rps6kb2 Elf4 Elf5 Ophn1 Mycbp Usf2 Grap2 Elp1 Rerg Nin Pkn2 Ninl Arhgap42 Pik3r5 Srf Elk1 Map3k4 Mapkapk2 Rps6ka4 Rps6ka5 Mknk2 Mknk1 Itpr3 Itpr2 Itpr1 Mapk1 Braf Ets1 Pik3c3 Mapk3 Jun Mapk8 Plcg1 Araf Plcg2 Nras Arhgap1 Prkca Raf1 Pik3r1 Pik3r2 Arhgap8 Shc2 Pik3cg Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Hras Ikbkb Mapk7 Stat6 Stat4 Mapk6 Elk4 Pdpk1 Myc Akt2 Jak3 Fos Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Shc1 Mapk15 Stat5a Stat5b Stat3 Stat2 Arhgap10 Stat1 Chuk Arhgap26 Ehf Srgap1 Srgap3 Rab11b Arhgap6 Arhgap5 Arhgap4 Erf Erg NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Slc44a3 Actr1a Acta1 Myo3a Acta2 Actr1b Actb Myo3b Chrnb1 Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh1 Myh2 Myh3 Myh15 Myh8 Myh9 Myh4 Myh6 Myh7 Myo1c Myo1b Myo1e Myo1d Myo5c Myo5b Myo1a Myh11 Myh14 Myh13 Myo1g Myo1f Plekhh3 Myh10 Myo18a Myo6 Myo18b Myo5a Myo9a Actg1 Slc5a7 Chrnd Chrne Chrng Actbl2 Chrna2 Chrna1 Actc1 Myo10 Chrna9 Myo15a Myo16 Chrnb4 Chrnb3 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Jak2 Stat6 Jak1 Stat5a Jak3 Stat5b Stat4 Stat3 Stat1 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism Sugct SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Phgdh Psph Psat1 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Pik3c2b Pik3c2a Vasp Ntn1 Rac2 Ntn3 Nfatc4 Rhou Rac1 Nfatc3 Ntn4 Nfatc2 Ablim1 Plcg1 Dcc Ntng1 Plcg2 Unc5b Unc5d Unc5c Pik3r5 Pik3r1 Pik3r2 Pik3cg Pik3cb Pik3cd Pik3ca ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc6a2 Slc6a3 Slc18a2 Slc6a19 Slc6a18 Slc6a15 Slc6a17 Slc6a20a Slc6a16 Slc18a1 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Fmo3 Ugt1a2 Cyp2a5 Inmt Ugt1a5 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism Sugct S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mat2a Mat1a Mtr CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Pfn1 Mylk3 Pfn3 Pfn2 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Pak5 Arpc1b Pak4 Tubb5 Arpc1a Tubb6 Tubb3 Tubb1 Wasl Mylk Limk1 Arpc4 Rock2 Tubb4b Rock1 Tubb4a Arpc3 Acta1 Myo3a Acta2 Actb Arpc2 Myo3b Arpc5 Myh1 Myh2 Myh3 Myh8 Myh9 Myh4 Myh6 Myh7 Rhoc Myh11 Myh14 Myh13 Myh10 Actg1 Actbl2 Actc1 Rac2 Rhou Rac1 Diaph2 Diaph1 Tubb2b Tubb2a Cfl1 Cfl2 Mylk2 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Rasa1 Map2k2 Rps6ka4 Map2k1 Rps6ka5 Irs1 Mapk1 Ins2 Irs2 Insr Irs4 Mapk3 Igf2r Igf2 Rps6kb2 Igf1 Insrr Igf1r Map2k3 Fos Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Raf1 Elk1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Ifng Jak2 Ifngr2 Jak1 Ifngr1 Stat1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Upp1 Upp2 Uprt Nme3 Nme2 Nme4 Uck1 Uck2 Uckl1 Adat2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc1a6 Vamp8 Vamp1 Gria4 Vamp3 Vamp2 Gria3 Snap29 Gria2 Snap25 Gria1 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Cacna1e Grm4 Grm7 Grm8 Vti1a Stx1b Cacnb1 Stx1a Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkar1a Prkar1b Prkx Prkacb Grm1 Grm5 Prkar2a Prkar2b Prkaca Gnai2 Gnai3 Gnb1 Cacna1a Cacna1b Gnai1 Adcy10 Grin2a APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Casp9 Ikbkb Nfkbia Mapk10 Igf2r Akt3 Akt2 Fos Trp53 Atf2 Eif2ak2 Birc3 Birc2 Tnf Madd Bcl2l11 Tnfrsf1b Tnfrsf1a Tradd Nfkb2 Nfkb1 Traf2 Bcl2l1 Xiap Map2k4 Endog Tnfsf10 Rela Chuk Relb Map3k1 Apaf1 Tnfrsf10b Lta Fadd Atf7 Ltb Atf6 Mapk1 Atf4 Atf3 Jdp2 Aifm1 Gzmb Map2k7 Gzmf Mapk9 Mapk3 Map4k4 Map4k3 Jun Mapk8 Fasl Atf6b Cradd Akt1 Bak1 Eif2s1 Map2k3 Casp8 Bcl2 Casp7 Prkra Casp3 Prkcq Bik Ripk1 Prkcg Map4k2 Prkch Diablo Bax Rel Prkcb Fas Daxx Map3k14 Prkcd Prkce Prkca Pik3cg Pik3cb Map3k5 Pik3cd Pik3ca LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Pak1 Map2k2 Map2k1 Pak3 Hras Pak2 Grb2 Mapk10 Gsk3a Pdpk1 Akt3 Kras Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Shc1 Atf2 Srf Elk1 Map2k6 Map3k4 Rhoc Mapk12 Mapkapk3 Rhoa Mapk13 Mapk14 Rhob Mapkapk2 Map2k4 Stat3 Stat1 Map3k1 Mapk11 Mapk1 Braf Ets1 Map2k7 Pik3c3 Mapk9 Mapk3 Jun Mapk8 Rac2 Akt1 Rac3 Map2k3 Rac1 Araf Nras Tiam1 Rala Ralb Exoc2 Raf1 Pld1 Pld2 Ralgds Rgl1 Pik3cg Pik3cb Pik3cd Pik3ca ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Plcb1 Gng3 Gng4 Gng7 Gnaq Map2k2 Gng8 Gngt2 Map2k1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Mapk1 Mapk3 Gng11 Gnb1 Prkca Raf1 Grk3 Grk2 Agtr1a Plcb3 Arrb2 Elk1 Arrb1 Gng10 Egr1 Agt Plcb2 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Polr2f Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Gtf2h4 Gtf2f2 Gtf2h3 Gtf2f1 Brf2 Brf1 Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Gtf2e1 Taf4 Taf2 Gtf2e2 Gtf2a1l Polr2c Taf1c Taf9 Polr2h P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Chek2 Gadd45b Gadd45a Wrn Hdac1 Traf2 Sfn Cdkn2a Mta2 Kat2b Gtse1 Pml Cdkn1a Cdk1 Sirt1 Cdc25c Pdpk1 Akt3 Akt1 Akt2 Ccne1 Trp63 Trp53 Tpte Pten Cdk2 Crebbp Mdm2 Atm Mdm4 Trp73 Ep300 Gadd45g Sin3a Sumo3 Pik3ca THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Vamp8 Vamp1 Vamp3 Vamp2 Trh Trhr Snap29 Stx3 Cga Snap25 Cacnb3 Cacnb4 Cacnb2 Snap23 Tshb Cacna1e Cacnb1 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Gng2 Plcg1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Gnb1 Cacna1a Prkce Cacna1b Prkca Prkcz ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b7 Hsd17b6 Hsd17b3 Soat2 Soat1 Hsd17b1 Hsd17b2 Lipa Cyp19a1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Ctnnb1 Cdh6 Pcdhgb6 Pcdhgb7 Cdh5 Cdh4 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Pcdh11x Cdh17 Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhgb1 Pcdhga5 Pcdhga6 Pcdhga7 Pcdhga8 Ctnnd2 Pcdhga1 Ctnnd1 Pcdhga2 Pcdhga3 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Acta1 Acta2 Actb Actr2 Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Wnt6 Wnt7b Wnt3a Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Actg1 Tcf7l2 Wnt3 Fzd1 Actbl2 Fzd3 Actc1 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b UNTITLED%PANTHER PATHWAY%P06664 untitled Tgif1 Skil Rela PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc2 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Pdha2 Suclg1 Mdh1 Ogdh Aco2 Sdhc Pdk2 Cs Fh Pdha1 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin2 Azin1 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 Mmut LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Dpysl2 Dpysl3 Cda Upb1 Nt5e Dpysl5 Aldh6a1 Dpys Abat Dpyd ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Gng3 Gng2 Gng4 Adcy7 Prkar2a Gng7 Adcy2 Prkar2b Gng8 Gngt2 Prkaca Gnb2 Gnb4 Gnb3 Gnb5 Gnb1 Gnal Gng12 Prkx Prkacb Adrb1 Gng10 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Foxo3 Gsk3b Tpte Pten Irs1 Mdm2 Mdm4 Tsc2 Ins2 Tsc1 Irs2 Insr Irs4 Gsk3a Igf2r Foxo1 Igf2 Igf1 Pdpk1 Insrr Pik3ca Igf1r HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gng3 Gng2 Gng4 Adcy7 Prkar2a Gng7 Adcy2 Prkar2b Gng8 Gngt2 Prkaca Gnb2 Gnb4 Gnb3 Gnb5 Gnb1 Gnal Gng12 Prkx Prkacb Gng10 Hrh2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gng3 Gng2 Gng4 Adcy7 Gng7 Adcy2 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gnb1 Gnal Gng12 Gng10 Adrb3 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Xdh Nt5e Ampd3 Gda METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Pomc Crh Gng3 Gng2 Crhr2 Gng4 Crhr1 Gng7 Gnaq Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gnb1 Gnal Gng12 Gna11 Gng10 Gna14 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Mapk13 Mapk14 Mapk7 Mapk11 App Mapk1 Cacnb2 Mapk10 Mapk9 Cacna1c Mapk6 Mapk3 Mapk8 Kat5 Cacna1f Cacna1d Prkcq Pkn3 Pkn2 Klc1 Bace2 Prkcg Adam17 Prkch Mapk4 Bace1 Prkci Klc4 Klc3 Prkcb Klc2 Cacna1s Apba1 Prkcd Apba2 Apba3 Prkce Prkca Pkn1 Psen1 Cacnb1 Psen2 Ncstn Prkcz Aph1b Mapk15 Mapk12 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Rac1 Ntn4 Dcc Ntng1 Cxcl12 Slit1 Slit2 Slit3 Robo1 Srgap1 Cxcr4 Abl1 Ntn1 Rac2 Ntn3 Rhoc DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Nme1 Nme3 Dscaml1 Nme2 Dhodh Nme4 Cad Ctps2 Ctps1 Cps1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Shc3 Rasa2 Pik3c2b Rasa1 Pik3c2a Rasa4 Map2k2 Map3k3 Map2k1 Map3k2 Hras Grap Stat6 Erbb4 Stat4 Gab1 Mapk10 Gab2 Akt3 Akt2 Sos2 Sos1 Pik3r5 Shc1 Map2k6 Map3k4 Mapk12 Erbb2 Mapk13 Erbb3 Mapk14 Stat5a Mras Stat5b Rasal2 Gab3 Egfr Map2k4 Stat3 Phldb2 Stat2 Nf1 Stat1 Rras2 Dab2ip Pebp4 Spry2 Spry3 Spry1 Spry4 Pebp1 Mapk11 Prkd3 Mapk1 Rras Prkd1 Braf Prkd2 Map2k7 Pik3c3 Mapk9 Mapk3 Mapk8 Rac2 Akt1 Map2k3 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Prkcd Prkce Prkca Raf1 Shc2 Pik3cg Prkcz Pik3cb Map3k5 Pik3cd Pik3ca PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Fgb Fga Mmp13 Fgg Mmp3 Plat Plg Mmp9 Mmp1a Plau Serpine1 Serpinf2 Plaur Serpinb2 PNAT%PANTHER PATHWAY%P05912 PNAT Gng3 Gng4 Gng8 Vamp8 Vamp1 Gnb2 Gnb4 Vamp3 Gnb3 Vamp2 Snap29 Stx3 Snap25 Prkx Snap23 Prkacb Epb41l2 Kcnk3 Epb41l3 Clic6 Ppp1r1b Drd1 Drd5 Ppp1cc Slc18a2 Adcy7 Gnaz Adcy2 Prkar2a Drd2 Prkar2b Drd4 Ppp1ca Prkaca Gnai2 Kcnk9 Epb41 Gng11 Gnai3 Gnb1 Flna Slc6a3 Gnai1 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Crebbp Shh Smo Ptch1 Sufu Fbxw11 Btrc Gli1 Gli3 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Slc5a7 Prkar1a Prkar1b Prkx Prkacb Gnao1 Prkar2a Prkar2b Prkaca Gnai2 Gng11 Kcnj9 Gnai3 Kcnj6 Kcnj5 Gnb1 Chrm2 Chrm4 Slc18a3 Adcy10 Gnat2 Gnai1 Slc6a8 Gnat1 Kcnj3 Gng10 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Gnpda1 Amdhd2 Gfpt1 Gnpda2 Gfpt2 Npl TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Jund Acvr1c Snip1 Lefty1 Tgfb2 Tgfb3 Gdnf Cited1 Acvrl1 Hras Cited2 Acvr1b Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Bmpr1b Gdf3 Gdf6 Bmp7 Gdf5 Bmp6 Mapk10 Bmp5 Gdf7 Bmp4 Bmpr2 Smad1 Bmp3 Smad2 Gdf9 Nodal Bmp2 Smad3 Smad4 Bmp1 Smad9 Acvr2a Tll2 Gdf15 Inhba Tll1 Inhbb Acvr2b Inhbc Tgfbr1 Smad5 Junb Tgfbr2 Smad6 Smad7 Crebbp Gdf11 Inhbe Gdf10 Atf2 Map3k7 Ep300 Mapk12 Mapk13 Mapk14 Tab1 Mapk11 Mapk1 Rras Mapk9 Mapk3 Jun Mapk8 Nras Bmp10 Bmp8a Bmp15 Skil Dcp1b Lefty2 Acvr1 Foxh1 Smurf2 Smurf1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation F10 F12 Proz Tfpi F2 Serpina10 F3 Thbd F7 F8 F9 Pros1 F2rl3 Fgb Itga2b Fga Fgg Plat Plg Plau Plaur F2r Klkb1 Kng2 Gp5 Proc Gp9 Gp1bb F13b Gp1ba Procr Vwf PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Casp9 Nos3 Gnaq Gngt2 Gnb2 Gnb4 Gnb3 Ptger1 Gnb5 Foxo4 Irs1 Gngt1 Ywhaz Insr Foxo1 Rps6kb2 Pdpk1 Akt3 Akt1 Akt2 Foxo3 Gnai2 Gsk3b Nras Gnai3 Gnb1 Sos2 Sos1 Gnat2 Gnai1 Pik3r5 Pik3r1 Pik3r2 Gna11 Gna14 Pik3cb Pik3ca HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Grm2 Gsk3a Crebbp Gng10 Ep300 Creb3l3 Creb3l4 Creb3l1 Hrh1 Gng3 Gng4 Creb3l2 Gng7 Gng8 Gngt2 Gnb2 Gngt1 Gng12 Adora2b Adora2a Prkar1a Adra2c Prkar1b Adra2b Htr6 Prkacb Htr7 Oprl1 Grm1 Phka1 Grm5 Phka2 Adrb2 Adra1b Adra1a Adra1d Sstr5 Sstr4 Oprd1 Sstr3 Sstr2 Sstr1 Oprm1 Adcy7 Htr5a Prkar2a Phkb Prkar2b Chrm1 Htr1d Chrm3 Htr1f Chrm5 Gnai2 Hrh4 Htr1b Hrh3 Htr1a Adora1 Adora3 Gnai3 Gnrhr Adcy3 Htr4 Gys1 Gnal Gys2 Clta Cltb Cltc Mtnr1a Adcy4 Creb1 Adcy1 Creb3 Adcy8 Phkg1 Adcy5 Phkg2 Adcy6 Mtnr1b Adcy9 Pygb Kcnj3 Htr2a Pygl Htr2c Pygm Htr2b Gpr50 Oprk1 Adrb1 Hrh2 Adrb3 Gsk3b Grm4 Grm7 Grm8 Rap1a Rap1b Drd1 Drd5 Gng2 Adcy2 Drd2 Drd4 Prkaca Kcnj9 Kcnj6 Gnb1 Kcnj5 Chrm2 Chrm4 Gnai1 Grm3 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Frs3 Shc3 Fgfr3 Rasa2 Pik3c2b Fgfr4 Rasa1 Pik3c2a Fgfr1 Rasa4 Fgfr2 Map2k2 Map3k3 Map2k1 Map3k2 Hras Grap Ptpn6 Mapk10 Akt3 Akt2 Sos2 Sos1 Shc1 Map2k6 Map3k4 Mapk12 Mapk13 Mapk14 Map2k4 Spry2 Spry3 Spry1 Spry4 Pebp1 Mapk11 Mapk1 Map2k7 Pik3c3 Mapk9 Mapk3 Mapk8 Rac2 Akt1 Map2k3 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Prkcd Prkce Prkca Raf1 Pik3cg Prkcz Pik3cb Map3k6 Map3k5 Pik3cd Frs2 Pik3ca ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Asl Nags Otc Ass1 Cad Cps1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gng3 Gng4 Gng7 Gng8 Gngt2 Cnga3 Pdc Gnb2 Cnga1 Gnb4 Grk1 Pde6g Gnb5 Calml3 Rho Gngt1 Gng12 Rgs9 Pde6a Pde6b Cngb3 Rcvrn Gng13 Gng2 Gnb1 Gnat1 Gng10 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Mapk14 Sfn Mapk7 Ywhaz Mapk1 Mapk10 Psma4 Psma3 Psma6 Psma5 Mapk9 Ccne2 Mapk3 Psma2 Mapk8 Psma1 Cask Ywhah Ywhag Ywhae Th Ccne1 Ywhab Psmb10 Sncaip Psmb7 Prkn Psmb1 Gpr37l1 Septin5 Septin4 Psmb3 Stx7 Septin2 Septin1 Stx12 Gpr37 Slc6a3 Ndufv2 Psma7 Pld2 Snca Elk1 Mapk15 Mapk12 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Gng3 Gng4 Gng7 Grin1 Gnaq Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Slc5a7 Itpr2 Itpr1 Grin2d Grin2c Grin2b Prkcq Pkn3 Chrm1 Pkn2 Chrm3 Prkcg Prkch Prkci Prkcb Gng11 Prkcd Gnb1 Slc18a3 Prkce Prkca Pkn1 Plcb4 Gna11 Gng10 Grin2a Gna14 Prkcz OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Oprd1 Gng3 Gng2 Gng4 Adcy7 Gng7 Adcy2 Gng8 Gngt2 Gnai2 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 Gnb1 Gng12 Gnai1 Pdyn Penk Gng10 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Rpa2 Top2b Prim1 Top2a Dna2 Top1 H3-3b Rfc5 Pold2 Pold1 H3c8 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pola1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Mcee Pcca Pccb Mmut DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Nme1 Rrm1 Nme3 Adsl Nme2 Rrm2 Nme4 Rrm2b Ak1 Gmps Ak3 Ak2 Nme5 Ak5 Adss2 Adss1 Ak8 Atic Nme7 Ppat Nme6 Dscaml1 Guk1 Gart VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Rxra F13b Vdr Rara Gc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Grm2 Gng13 Cacna1e Grm4 Grm7 Grm8 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Rhoa Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Rap1a Gnb2 Rap1b Gnb4 Gnb3 Itpr3 Gngt1 Gng12 Itpr2 Adora2b Itpr1 Adora2a Grm1 Oprl1 Grm5 Sstr5 Sstr4 Rap1gap Oprd1 Sstr3 Drd1 Sstr2 Rasgrp3 Drd5 Sstr1 Rasgrp4 Gnao1 Gng2 Oprm1 Rasgrp1 Rasgrp2 Prkcq Arhgef1 Dnajc27 Drd2 Garnl3 Chrm1 Drd4 Prkcg Bdkrb2 Chrm3 Prkch Bdkrb1 Chrm5 Prkci Gpr45 Prkcb Adora1 Adora3 Gnrhr Prkcd Gnb1 Chrm2 Cacna1a Clta Prkce Chrm4 Cacna1b Cltb Prkca Cltc Prkcz Oprk1 Grm3 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Ephb2 Ephb3 Dll3 Rasa1 Dll4 Dlk1 Pdgfrb Apc Pdgfra Tek Pdgfa Pdgfb Grap Nck2 Jak1 Nck1 Ctnnb1 F2r Hspb1 Mapkapk3 Mapk14 Mapkapk2 Map2k4 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Jun Cryab Mapk8 Cryaa Kdr Akt1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Frs2 Pik3ca Crkl Frs3 Casp9 Nos3 Pik3c2b Pik3c2a Fgfr1 Ptk2 Pak1 Map2k2 Tgfb1i1 Map2k1 Pak3 Hras Pak2 Wnt5a Akt3 Akt2 Wnt5b Wnt10a Fos Wnt10b Gsk3b Notch4 Sos2 Notch1 Sos1 Notch2 Shc1 Rhoc Rhoa Rhob Rbpjl Wnt7b Stat3 Dvl1 Dvl2 Stat1 Dvl3 Wnt7a Map3k1 Wnt2 Wnt1 Tcf7l2 Fzd1 Fzd3 Fzd2 Fzd5 Crk Rbpj Src Wnt2b Grb14 Fgf1 Dok1 Dok2 Dok3 Axin1 Grb7 Pdgfc Tcf7 Pld1 Pdgfd Pld2 Efnb1 Jag2 Efnb2 Jag1 Pla2g4c Pla2g4d Birc5 Angpt1 Apc2 Epha3 Ephb1 Dll1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Nme1 Dut Dtymk Rrm1 Nme3 Dscaml1 Nme2 Rrm2 Nme4 Rrm2b Tyms Adat2 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Syt5 Syt3 Vamp1 Syt2 Syt1 Syt11 Syt12 Syt7 Syt6 Rab3a Snap25 Stxbp1 Unc13c Unc13b Stx1b Syt15 Stx2 Stx1a Unc13d GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Lyn Ppp3ca Jak2 Nfkbia Grb2 Mapk10 Eif4ebp1 Nr2c2 Clu Ier3 Sp1 Sp3 Elavl1 Akt1s1 Yes1 Snai1 Tcf4 Ryr2 Ryr1 Hbegf Ryr3 Ctnnb1 Nos1 Hdac7 Akap1 Cckbr Pparg Gucy2e Arhgef28 Cd38 Ptgs2 Camk4 Map2k5 Ptpn11 Tpcn1 Tpcn2 Bad Cck Gast Traf6 Map3k11 Srf Mef2d Elk1 Map2k6 Hspb1 Mapk14 Eif4e Map2k4 Mef2c Itpr1 Mapk1 Pla2g4a Prkd1 Prkacb Braf Prkd2 Mapk9 Mapk3 Jun Mapk8 Akt1 Bcl2 Rac1 Nfatc2 Plcg1 Araf Prkcq Prkch Prkcb Prkcd Prkce Prkca Raf1 Pik3r1 Prkg1 Creb1 Adcy1 Pxn Pik3cb Ptk2 Pak1 Map2k2 Map2k1 Odc1 Mapk7 Irs1 Rock1 Foxo1 Elk4 Cdh1 Pdpk1 Ywhab Foxo3 Fos Rps6ka3 Gsk3b Rps6ka1 Sos1 Shc1 Atf2 Itgav Rhoa Bcl2l1 Stat3 Itgb1 Mmp3 Plau Crk Src Gng2 Slc18a2 Bcar1 Casp3 Prkaca Bax Map3k14 Gnb1 Ptk2b Arrb2 Egr1 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Pgam2 Pfkm Gpi Hkdc1 Hk2 Hk1 Aldoa Tpi1 Pklr Bpgm Eno2 Pfkl Pkm EG433182 Pgk1 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Rbpj Ncor2 Dll3 Cirsr Dll4 Dlk1 Rbpjl Maml1 Numb Notch4 Notch1 Notch2 Notch3 Jag2 Jag1 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Gad1 Abat Aldh5a1 Gad2 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Casp9 Map2k4 Faf1 Parp4 Parp3 Apaf1 Parp2 Parp1 Cflar Fadd Lmnb1 Lmnb2 Gsn Casp6 Capg Lmna Mapk10 Scin Dffb Mapk9 Jun Mapk8 Fasl Casp8 Casp7 Casp3 Fas Daxx Map3k5 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Jund Vav1 Grap Jak2 Kras Myo3a Myo3b Junb Myh1 Myh2 Myh3 Plcb4 Myh8 Plcb3 Myh9 Myh4 Gna11 Gng10 Myh6 Myh7 Gna14 Plcd1 Plcb2 Vwf Plcd4 Plcb1 Gng3 Gng4 Myh11 Gng7 Myh14 Gnaq Myh13 Gng8 Plcz1 Plce1 Myh10 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 Mapk1 Prkx Prkacb Cxcr3 Cxcr5 Mapk3 Cxcr6 Cxcl10 Jun C5ar1 Fpr1 Rac2 Ccr10 Akt1 Ccr1 Nfatc4 Xcr1 Ccrl2 Rac1 Nfatc3 Gnao1 Ltb4r2 Nfatc2 Plcg1 Rhog Araf Fpr-s1 Ccr9 Plcg2 Ccr8 Ccr7 Ccr6 Gnai2 Nfatc1 Nras Ccr5 Prkcb Ccr4 Ccr3 Gnai3 Ccr2 Cx3cr1 Ifnar1 Prkce Camk2d Ccl11 Raf1 Ccl12 Ccl7 Camk2a Ccl5 Ccl4 Adcy5 Ccl3 Adcy6 Ccl2 Pf4 Prex1 Pik3cg Cx3cl1 Prkcz Nfat5 Col14a1 Pik3cb Ccl22 Pik3cd Ccl20 Mylk2 Pik3ca Mylk3 Pak1 Pak6 Pak3 Pak2 Ikbkb Pak5 Arpc1b Pak4 Arpc1a Cxcr1 Mylk Cxcr2 Arpc4 Rock1 Cask Pdpk1 Akt3 Ifng Akt2 Arpc3 Acta1 Acta2 Actb Arpc2 Sos1 Shc1 Arpc5 Il2 Cxcr4 Col12a1 Rhoc Rhoa Nfkb2 Stat3 Itgal Rela Chuk Relb Itgb7 Actg1 Itgb1 Rras Actbl2 Actc1 Col20a1 Arpc5l Gng2 Adcy2 Prkaca Col6a1 Col6a2 Ptk2b Gnai1 Col6a3 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Hprt1 Pnp Gda HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Hip1 Bdnf Ift57 Dync1h1 Grin1 Dnal4 Dctn1 Rhoj Rhoq Dync1i2 Dync1i1 Arpc1b Ap2a2 Ap2a1 Tubb5 Arpc1a Hap1 Tubb6 Hip1r Tubb3 Kalrn Tubb1 Htt Gapdhs Dync1li2 Dync2h1 Grik5 Dync1li1 Dnai2 Tubb4b Dynll1 Grik2 Dynll2 Grik1 Tubb4a Capn9 Grik4 Cyc1 Grik3 Capn5 Grin2d Sp1 Capn7 Grin2c Capn6 Capn1 Grin2b Capn3 Capn2 Dnah3 Dlg4 Dnah5 Dnah8 Cyfip2 Cyfip1 Capns1 Trp63 Fos Capn10 Capns2 Capn11 Acta1 Acta2 Actb Trp53 Actr2 Crebbp Arpc5 Trp73 Ep300 Map2k4 Apaf1 Map3k10 Tbp Actg1 Actbl2 Actc1 Map2k7 Mapk9 Jun Arpc5l Rac2 Taf4 Rac1 Casp8 Rhog Casp3 Cltb Tubb2b Tubb2a Grin2a ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Pdha2 Pklr Acly Pcx Cs Pkm Me1 Clybl Pdha1 Pck1 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Vav3 Vav1 Pak1 Map2k2 Vav2 Map2k1 Pak3 Hras Pak2 Ikbkb Nck2 Ptprc Ppp3ca Ppp3cb Nck1 Nfkbia Akt3 Akt2 Grap2 Fos Sos2 Zap70 Sos1 Cd28 Cd86 Cd80 Lck Lcp2 Cd3g Cd247 Cd3e Cd3d Ppp3cc Lat Chuk Map3k1 Itpr1 Mapk1 Braf Pik3c3 Mapk9 Mapk3 Jun Mapk8 Akt1 Rac1 Plcg1 Araf Prkcq Nras Raf1 Pik3r1 Pik3r2 Pik3cg Pik3cb Pik3cd Pik3ca TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Irak4 Ticam1 Ecsit Mapk14 Nfkbie Tollip Irak1 Map2k2 Myd88 Tank Map2k1 Irf3 Tlr9 Chuk Ikbkb Tlr8 Tlr7 Tlr6 Tirap Tlr4 Tab1 Tlr3 Tlr2 Nfkbia Mapk9 Mapk3 Jun Mapk8 Map2k3 Traf6 Elk1 Map3k7 Map3k8 Ikbke Tbk1 Ticam2 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Pdxk Psat1 Pnpo WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Csnk1d Csnk1e Smarca5 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Smad1 Smad4 Ctnnb1 Ppp2cb Ppp2ca Smad5 Siah1a Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 Nfatc4 Nfatc3 Nfatc2 Gng13 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Lrp6 Lrp5 Wnt6 Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Tcf7l2 Wnt3 Fzd1 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Axin1 Arrb2 Arrb1 Hdac1 Ppp3ca Ppp3cb Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb6 Pcdhgb7 Cdh5 Cdh4 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Crebbp Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Ep300 Pcdha5 Pcdha4 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Pcdh11x Cdh17 Cdh16 Prkcq Cdh15 Cdh13 Prkcg Cdh12 Prkch Cdh11 Prkci Nfatc1 Cdh10 Prkcb Pcdh8 Pcdh7 Pcdh9 Prkcd Pcdhgb1 Pcdhga5 Prkce Pcdhga6 Prkca Pcdhga7 Pcdhga8 Pcdhga1 Pcdhga2 Pcdhga3 Prkcz Gsk3b Ppp3cc Arr3 Smarce1 Srcap Tbl1x Nlk Kremen2 Kremen1 Siah2 Ino80 Csnk2a2 Ep400 Hells Hltf Csnk1a1 Ppp2r5d Smarcal1 Ppp2r5c Gng2 Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Arid1a Fbxw11 Btrc Pygo2 Pygo1 Tle4 Tle3 Tle2 Tle1 Gnb1 Ctnna3 Ctnna2 Ctnna1 Tle6 Bcl9 Csnk1g3 Hdac3 Csnk1g2 Hdac2 Tbl1xr1 Smarcb1 Hdac8 Csnk2b Smarca2 Sag Smarca1 Smarca4 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Hprt1 Xdh Aprt Ada Pnp TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Grm2 Gng3 Gng4 Gng7 Gng8 Gngt2 Vamp8 Vamp1 Gnb2 Gnb4 Vamp3 Gnb3 Vamp2 Gnb5 Snap29 Snap25 Prkar1a Prkar1b Prkx Snap23 Prkacb Gnao1 Prkar2a Prkar2b Prkaca Gnai2 Gng11 Gnai3 Gnb1 Cacna1e Cacna1a Adcy10 Cacna1b Gnat2 Gnai1 Stx1b Cacnb1 Stx1a Gng10 Grm3 UNTITLED%PANTHER PATHWAY%P05916 untitled Gnao1 Gng3 Gng2 Gng4 Adcy7 Gng7 Adcy2 Gng8 Avp Gngt2 Oxt Gnai2 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 Gnb1 Gng12 Gnai1 Pdyn Gng10 Oprk1 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Rhoa Rac1 Arhgef1 Pak1 Fyn Dpysl2 Nrp1 Dpysl4 Plxnb1 Sema3a Sema4d Dpysl5 Cdk5 Fes Dpys Crmp1 Frk Rac2 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Plcb1 Gnao1 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gng11 Gnb3 Gnai3 Gnb1 Cacna1a Cacna1b Gnai1 Grm1 Grm5 Cacna1g Plcb3 Cnr1 Plcb2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Cavin1 Ubtf Ttf1 Psmc3ip Tbp Tbpl2 Tbpl1 Taf8 Rrn3 Taf1c Taf1a Polr1b Taf1b Polr1d Polr2k PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway Pdxk Pnpo SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Cda Tk1 Adat2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Gng3 Gng2 Gng4 Adcy7 Prkar2a Gng7 Adcy2 Prkar2b Gng8 Gngt2 Prkaca Gnb2 Gnb4 Gnb3 Gnb5 Gnb1 Gnal Gng12 Prkx Prkacb Adrb2 Gng10 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Oprd1 Gnao1 Gng2 Adcy7 Oprm1 Adcy2 Prkar2a Prkar2b Prkaca Gnai2 Gnai3 Gnb1 Gnal Gnai1 Pdyn Creb1 Penk Gng10 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Plcb1 Adra2a Prkcg Plce1 Prkcd Prkce Prkca Itpr1 Adra2c Adra2b Plcb4 Plcb3 Gna11 Adra1b Adra1a Plcb2 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Agt Ace ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway Kdr THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Pdha1 Idh3g Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Ikbkb Cd40 Mapk14 Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 Cd40lg Dusp1 Nfkb1 Chuk Tnfaip3 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Vac14 Sacm1l Inpp1 Pik3cb Pik3r4 Plcb4 Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Impa1 Mtor Isyna1 Becn1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Agt Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Gys1 Gaa Agl Ugp2 Pygl Amy1 Pgm1 Ugdh Gpi Ugt3a2 Gusb Pgm2l1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 Cyp2c65 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Gls2 Glud1 L2hgdh Pcx D2hgdh Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Gusb Ugt8 Hk1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Mapk8 Nfkbia Shc1 Map3k1 Ptpn7 Cd3g Cd247 Nfkb1 Elk1 Map2k7 Cd3d Mapk3 Ubc Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Fos Rela Nfat5 Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Nqo1 Nos3 Abcb1a Abcg2 Ralbp1 Por Abcc1 Abcc2 Slc22a16 Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 Cbr1 Akr1c18 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Amt Cps1 Glul Dld Gls2 Glud1 Hal Sds Gldc Aqp8 Asrgl1 Asns TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Map2k1 Itpr1 Raf1 Cacna1f Cacna1c Cacna1d Hras Mapk1 Cacna1s Nfkbia Nfkb1 Prkcb Mapk3 Prkca Rela Plcb1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Itpr1 Prkca Gnaq Plcb1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Synj1 Vac14 Inpp4b Pik3c2a Pten Pik3c3 Pik3r4 Egfr Pik3r1 Fig4 Cdipt Ambra1 Pik3cd Pip5k1a Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Erbb2 Plcb1 Becn1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Srm Odc1 Mat2b Mat2a ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Agt Ace MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Ldhd Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Gmds Pfkl Tpi1 Fbp1 Aldoa Gmppa Pmm1 Mpi Uxs1 Akr1b1 Sord Khk Pfkfb1 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Tyms Rrm2b Dck Cmpk1 Nme1 Dctd Nt5c Slc28a3 Slc29a1 Slc28a1 Ctps1 Rrm1 Rrm2 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Pdia2 Sdf2l1 Comt Hyou1 Cyp2e1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a5 Ugt1a1 Hspa5 Ephx1 Cyp3a16 Cyp2c50 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Nqo1 Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Hsd17b10 Acat1 Hadh Acadl Acads Acaa2 Echs1 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Cyp3a16 Cyp2d22 Sult1a1 Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Qars1 Rps15a Rps18 Rps19 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Aldh1a1 Cyp3a16 Cyp2b10 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Agt Ace DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Dct Tyr PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Gmds Pfkl Tpi1 Fbp1 Aldoa Gmppa Pmm1 Mpi Uxs1 Akr1b1 Sord Khk Pfkfb1 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway Cyp3a16 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Agt Ace INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Creb1 Gngt1 Fshr Prkacb Cga Gng12 Ppp1ca Gnb1 Adcy2 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Ddc Pnmt Th GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Acsm1 Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2b10 Ugt1a9 Slc22a1 Abcc2 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Per1 Npr1 Cry1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Map2k1 Lyn Lck Cd79b Grb2 Orai1 Blnk Raf1 Hras Mapk8 Shc1 Map3k1 Elk1 Prkcb Mapk3 Plcg1 Rac1 Prkca Ppp3ca Jun Ppp3cb Syk Fos Nfat5 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Tub Gngt1 Chrm1 Htr2c Gnaq Gnb1 Plcb1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Eprs1 Rpl4 Rps16 Rps15a Rps18 Rps19 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Farsa Farsb Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Agt Ace GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Bpgm Pgam1 G6pc1 Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Cyp3a16 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Cyp2e1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a1 Hspa5 Abcb1a Sult1e1 Sult2a1 Abcg2 Abcc4 Abcc5 Abcc1 Ugt2b36 Gstt1 Cyp2d22 Sult1a1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Pccb Mmut Dbt Dld Bckdhb Sds Pcca Bckdha METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp3a16 Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Ugt1a9 Cbr1 Cyp2d22 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Aars1 Rps16 Rps15a Rps18 Rps19 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Sdhd Sdhc Sdhb Sdha Ndufa1 ATP6 mt-Co1 Uqcrc1 Atp5f1d Atp5f1c Atp5pb Atp5f1b Atp5f1a Gpd2 Slc25a4 Slc37a4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Vkorc1 Nqo1 Ggcx LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Cyp3a16 Cyp1a2 Scn1b 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs Acacb Spcs1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Agt Ace OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Gaa Ugp2 B4galt1 G6pc1 Pgm1 Gale Glb1 Lct Gla Akr1b1 Hk1 Galt FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp3a16 Aldh3a1 Cyp2e1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpk1 Inpp4b Nudt3 Minpp1 Itpka Inpp4a Ipmk Ippk Impa1 Bpnt1 Ip6k1 Isyna1 Inpp5j BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Acat1 Hadh Acads Echs1 Acsm1 Hmgcl Oxct1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Fdps Hmgcr Acat1 Idi1 Mvd Mvk Fdft1 Lss Sqle Pmvk BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Gpi Pkm Pfkp Tpi1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Pgs1 Gpam Gpd1 Crls1 Cdipt Cds1 Pla2g2d Ptdss1 Ptdss2 Gde1 Plpp1 Pisd Phospho1 Pld2 Pcyt1a Pla2g15 Lypla1 Ptpmt1 Chat Dgka Pemt Chka Agpat1 Gpd2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C9 Cfp C8a Cfb Cfd C3 C5 C6 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Slc6a4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Sptlc1 Acer2 Cerk Sptlc2 Enpp1 Degs2 Gba1 B4galt2 Ugt8 Sphk2 Ugcg Sdr16c5 Gla HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Cat Sod3 Sod2 Tyrp1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Cyp3a16 Abcb1a Abcg2 Pdia2 Sdf2l1 Abcc1 Abcc2 Hyou1 Pdia6 Pdia4 Ppib Bche Dnajb11 Ces2h Ces1d Ugt1a9 Top1 Erp29 Ugt1a1 Hspa5 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Agt Ace WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Ireb2 Gsr Glud1 Pkm Sdhd Sdhc Hk1 Sdhb Sdha Cs EG433182 Idh3g Mdh1 Pgd Mpc1 Fh Idh1 Idh3a Slc2a13 Cad Gapdhs Bpgm Aco1 Rpia Gpi H6pd Tktl1 Taldo1 Pfkm Bckdhb Pdhx Aldoc Gls Acly Ogdh Pgk2 Sucla2 Slc16a1 PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway Cyp3a16 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Tubb1 Cdkn1a Abcc10 Cyp3a16 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Map2k1 Socs1 Irs1 Grb2 Insr Ptpn6 Raf1 Ghr Stat5a Stat5b Hras Mapk1 Rps6ka1 Slc2a4 Ins2 Sos1 Jak2 Shc1 Mapk3 Plcg1 Prkca KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Slc14a2 Atp1a2 Atp1a1 Atp1a3 Aqp3 Aqp2 Atp6v1b1 Ca1 Slc4a1 Scnn1a Scnn1b Scnn1g Atp1b1 Atp1b3 Atp1b2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Vac14 Pik3c3 Pik3r4 Ptpmt1 Pik3cd Prex1 Inpp5f Plce1 Inppl1 Zfyve16 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Vars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Mapk8 Map3k1 Jun Faf1 Arhgdib Map3k7 Pak1 Prkdc Ripk2 Fasl Parp1 Cflar Pak2 Lmnb1 Ptpn13 Lmnb2 Casp8 Rb1 Casp7 Casp3 Casp6 Sptan1 Lmna Map2k4 Fas Fadd Daxx Dffa Dffb ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Tubb1 Slco1b2 Abcb1a Abcg2 Abcc1 Tuba1b Abcc2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Agxt Gpt Mpc1 Pcx Aars2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Rpe Rpia Tpi1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Adam17 Prkca Erbb4 Erbb3 Psen1 Nrg2 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Agt Ace FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Alox15 Ugt1a2 Cyp4f17 Cyp4f15 Slc22a8 Ptgds Cyp3a16 Cyp2j6 Cyp4f3 Cyp2c50 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Pdia2 Ptgis Sdf2l1 Cyp2c65 Hyou1 Cyp2e1 Pdia6 Ephx2 Pdia4 Ptgs1 Ppib Alox12b Slc22a6 Dnajb11 Ptgs2 Ugt1a9 Erp29 Cbr1 Ugt1a1 Hspa5 Ugt2b1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Aqp1 Slc7a8 Slc7a9 Slc4a4 Slc6a20a Slc9a1 Ca1 Slc22a2 Slc22a6 Slc1a1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 Slc7a5 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Map2k1 Grb2 Ptpn6 Raf1 Epo Epor Stat5a Hras Sos1 Jak2 Mapk8 Shc1 Elk1 Mapk3 Plcg1 Jun Fos CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp3a16 Oprm1 Cyp2d22 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Rpe Rpia Pgm1 Dera Prps1 Gpi Pgls Pfkl G6pdx Tkt Fbp1 Aldob HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Rapgef4 Glp1r Camkk1 Itpr3 Abcc8 Cacna2d2 Cacna1a Slc2a2 Chrm3 Cacnb1 Prkca Gng2 Adcy10 Gnaq Vamp2 Gnb1 Plcb1 Rab3a LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Creb1 Htr6 Gngt1 Prkacb Ppp1ca Gnb1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Cyp3a13 Cyp3a16 Oprm1 Cyp2d22 Grin2a Cyp2c50 Cyp2b10 Grin1 Cyp2c65 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Cbs Cth Mettl6 Mars1 Scly Sephs2 Ggt1 Mat2b Slc39a8 Papss1 Mat2a GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Gngt1 Prkacb Gnb1 Adcy2 Ptgdr DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gys1 Ganab Hkdc1 Pgm2 Gpi Gbe1 Hk1 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Itpr1 Akt1 Adcy1 Rock1 Lpar4 Srf Gng2 Gnb1 Plcb1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Ntpcr Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Hsd17b1 Cyp19a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 Asns CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Map2k1 Itpr1 Nfkb1 Prkcb Raf1 Mapk3 Hras Mapk1 Prkca Nfkbia Rela Plcb1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Acss1 Haao Mif Dbh Tyr Fah Comt Cyp2e1 Dct Cat Aldh1b1 Aldh2 Acss2 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Map2k1 Irs1 Grb2 Ptpn6 Raf1 Ghr Stat5a Stat5b Hras Mapk1 Rps6ka1 Slc2a4 Ins2 Jak2 Shc1 Mapk3 Gh Plcg1 Prkca 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Agxt Gpt Mpc1 Pcx Aars2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Ugp2 Pgm1 Ugdh Galk1 Gale Gck Uxs1 Galt PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Akt1 Plcg1 Pik3cg Prkca Pik3r6 Vav1 Plcb1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Nmnat3 Nmnat2 Nadk Nqo1 Npr1 Nmnat1 Clock Nampt Ppargc1a Rora Sirt1 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Htr7 Creb1 Gngt1 Prkacb Ppp1ca Gnb1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Ugt1a2 Slc22a8 Cyp3a16 Cyp2c50 Pdia2 Sdf2l1 Cyp2c65 Hyou1 Pdia6 Ptgs1 Pdia4 Ppib Slc22a6 Dnajb11 Ptgs2 Ugt1a9 Ugt2b1 Erp29 Ugt1a1 Hspa5 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Pgam2 Galm Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Slc2a1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp1a2 Cyp2c50 Slc6a2 Slc6a4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Slc9a1 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Prkar1b Kcnj4 Chrm2 Prkar2a Kcnk1 Prkar2b Kcnq1 Atp1b4 Slc8a1 Mcu Adrb1 Atp1b1 Prkacb Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cyp1a2 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Chrna4 Chrna3 Cyp2b10 Ugt1a9 Cyp2a5 Fmo3 Chrnb2 Ugt1a5 Aox1 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Shmt1 Bbox1 Aldh9a1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Slc29a2 Paics Slc28a2 Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Nme2 Ak2 Ak1 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Slc29a2 Paics Slc28a2 Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Mpst Ctns Cdo1 Cth Cars1 Gclc Got1 Gclm Ldha MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Egfr Rasa1 Srf Stat6 Jak1 Egf Sos1 Stat3 Stat2 Mapk8 Stat1 Shc1 Map3k1 Elk1 Mapk3 Jun Fos Map2k1 Grb2 Raf1 Hras Map2k4 Prkcb Plcg1 Prkca FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Gmds Pfkl Tpi1 Fbp1 Aldoa Gmppa Pmm1 Mpi Uxs1 Akr1b1 Sord Khk Pfkfb1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Pdxp Pnpo Aox1 Pdxk Alpl NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Ugp2 Galk2 Pgm1 Ugdh Gale Uxs1 Hk1 Galt EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Agt Ace PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Mars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Tyms Ces1d Tymp Cda Slc28a1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Flad1 Rfk Acp1 Enpp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Ugt1a2 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Pdia2 Slc6a4 Sdf2l1 Slc6a3 Hyou1 Adra1a Pdia6 Scn10a Pdia4 Pcsk2 Ppib Chrna4 Dnajb11 Oprm1 Htr1a Ugt1a9 Erp29 Ugt1a1 Hspa5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Ugt2b36 Ugt2b1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Hsd17b10 Acat1 Hadh Acadl Acads Acaa2 Echs1 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Plpp1 Gnpat Cept1 Agps Agpat1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Sult1a1 Chst11 Sult2b1 Suox Papss2 Bpnt1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Agt Ace CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Ptgs1 Cyp3a16 Ptgs2 Cyp2d22 Ugt1a9 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Nme2 Ak2 Ak1 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Atp1a2 Atp1b1 Atp1a1 Atp1b3 Atp1a3 Gck Atp1b2 Treh Slc2a2 Slc5a1 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Cyp3a13 Maoa Cyp2d22 Cyp2c50 Aox1 Slc6a4 Maob ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Slc25a22 Gpt Slc1a4 Glud1 Slc38a4 Slc2a4 Slc2a2 Gpt2 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Tyms Rrm2b Dck Cmpk1 Nme1 Dctd Nt5c Slc28a3 Slc29a1 Slc28a1 Ctps1 Rrm1 Rrm2 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Gls2 Glud1 Pkm Pcx Sdhd Sdhc Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Pdha1 Idh3g Suclg1 Mdh1 Pgd Pklr Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Ldha Dlst Pdhb Aldob Idh3b Aco2 Dlat Aco1 Dld Rpia Gpi Pfkl G6pdx Pgk1 Taldo1 Tkt Slc2a2 Slc1a5 Hk2 Slc16a1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Gls2 Glud1 Pkm Pcx Pfkp Sdhb Sdha Cs EG433182 Dhtkd1 Suclg1 Mdh1 Pgd Mpc1 Suclg2 Fh Idh1 Idh3a Pdhb Idh3b Aco2 Dlat Tktl2 Aco1 Pdha2 Dld Slc16a4 Slc1a2 Rpia Gpi G6pdx Pgk1 Taldo1 Hk2 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Sc5d Cyp51a1 Hsd17b7 Nsdhl Msmo1 Dhcr7 Lbr Dhcr24 Ebp ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Tyk2 Mapk1 Jak1 Stat3 Mtor IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway Bche Oprm1 Ces2h Ces1d INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Vac14 Synj1 Plcb4 Pik3c3 Ptpmt1 Cct3 Pik3ca Ipmk Bpnt2 Impa1 Isyna1 Becn1 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Map2k1 Raf1 Hras Pik3ca Vav3 Rala Ralbp1 Casp9 Pld1 Rhoa Bad Ralgds Bcl2l1 Smad3 Elk1 Smad4 Chuk Apaf1 Akt1 Foxo4 Mapk3 Rac1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Cyp11a1 Agtr1a Hsd3b6 Gng2 Cyp21a1 Gnaq Gnb1 Cyp11b2 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Ddc Pnmt Th ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Egfr Abcb1a Abcg2 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Mpst Ctns Cdo1 Cth Cars1 Gclc Got1 Gclm Ldha ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b Itgb3 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Itpr1 Akt1 Adcy1 Rock1 Lpar5 Srf Gng2 Gnb1 Plcb1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Aldh1a1 Cyp3a16 Aldh3a1 Cyp2b10 Cyp2a5 Cyp2c65 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Glp1r Slc10a2 Gpbar1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Map2k1 Irs1 Grb2 Insr Raf1 Hras Mapk1 Slc2a4 Ins2 Sos1 Mapk8 Shc1 Akt1 Pik3cg Pik3r6 Irs2 Map2k2 Pdpk1 Foxo1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Lars1 Rps19 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Synj1 Nudt3 Ipmk Bpnt2 Impa1 Isyna1 Ip6k1 Ppip5k1 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Vac14 Synj1 Plcd4 Pik3c3 Pik3r4 Impa1 Becn1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b Itgb3 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Prkacb Drd1 Adcy2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Cyp3a13 Cyp3a16 Cyp2c50 Cyp2b10 Ephx1 Cyp2c65 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Cdkn1a Pcna Ccne1 Ccnd1 Gadd45b Cdk4 Cdk2 Bcl2 Cdk1 E2f1 Bax Rb1 Apaf1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C9 C8a Cfb C1qb C1qa C1rb Serping1 Masp2 C2 C4a C1s2 C1qc Mbl2 Cfd C3 C5 C6 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma4 Ubc Psmc6 Psma3 Psmc5 Psma6 Psma5 Psmc2 Psmc1 Psma2 Psmc4 Psmc3 Psma1 Ubd Psmd13 Ube2e1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmd4 Psmb2 Stub1 Uba1 Psma7 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Itpr1 Mapk8 Map3k1 Elk1 Map2k7 Jun Map2k1 Grb2 Raf1 Hras Mapk1 Pld1 Gna11 Src Fshb Lhb Gnrh1 Prkcb Gnrhr Hbegf Camk2a Cga Adcy5 Prkca Cdc42 Egr1 Mmp14 Erbb4 Lrrc7 Mmp2 Actn4 Plcb1 Atf4 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Nat1 Cyp3a16 Cyp1a2 Xdh Cyp2a5 Cyp2c65 Cyp2e1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Cyp3a16 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Gmds Gmppb Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Hk1 Fbp1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk Pfkfb1 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Gpi Hk2 Pkm Pfkp EG433182 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Cd79a Nfatc4 Nfatc1 Nfatc3 Nfatc2 Sos1 Ppp3cc Btk Mapk8 Shc1 Map3k1 Elk1 Mapk3 Rac1 Ppp3ca Jun Vav1 Ppp3cb Syk Fos Map2k1 Lyn Cd79b Grb2 Orai1 Blnk Raf1 Hras Prkcb Plcg1 Prkca LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Itpr1 Akt1 Adcy1 Rock1 Srf Gng2 Lpar1 Gnb1 Plcb1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Acat1 Hmgcl Bdh1 Oxct1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 Asns LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Mpo Cyp3a16 Top2a PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pcyt2 Pisd Pcyt1a Cept1 Pemt Chka HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Itpk1 Vac14 Sacm1l Inpp1 Minpp1 Pik3r4 Cct3 Ambra1 Pik3ca Plcd1 Itpka Miox Ptpmt1 Pi4ka Impa1 Isyna1 Becn1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Casp3 Gzmb Hmgb2 Endog Dffa Cad Casp7 Top2a GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b Itgb3 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Prkar1b Prkar2a Prkar2b Gngt1 Prkacb Prkar1a Adcy10 Prkaca Gnb1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Kars1 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Tktl2 Rpe Rpia Pgm1 Dera Prps1 Gpi G6pdx Taldo1 Pfkp Fbp1 Rbks TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Gusb Ugt8 Hk1 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C9 C2 C4a C8a C1s2 C1qc C1qb C3 C1qa C1rb C5 C6 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Pgam2 Bpgm Galm Pgam1 G6pc1 Gpi Pkm Pfkm Tpi1 Slc2a2 Aldob EG433182 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Fbp1 Hk1 Sord Aldoa CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Gusb Ugt8 Hk1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Nmnat2 Nt5c2 Nadk Enpp1 Pnp Nudt12 Nnmt Qprt Nmrk1 Bst1 Nampt Nnt Aox1 Nadsyn1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Gpi Hk1 Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Cyp3a16 Abcb1a Pdia2 Sdf2l1 Hyou1 Top2a Mpo Pdia6 Ptgs1 Pdia4 Ppib Dnajb11 Ptgs2 Erp29 Ugt1a1 Hspa5 Abcc3 Top2b IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Slc22a1 Abcb1a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Aanat Tph1 Kmo Inmt Aadat Wars2 Ddc Wars1 Tdo2 Kynu Cyp1a1 Acmsd Haao Ido1 Cat Aldh2 Afmid LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Ikbkb Traf6 Pfkp Slc25a1 Sdhd Ikbkg Sdhc Myd88 Sdhb Ly96 Nfkbia Sdha Cd14 Cs Tirap Tlr4 Nfkb1 Chuk Acaca Mdh1 Acly Me1 Rela HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Avpr2 Gngt1 Fshr Prkacb Gng12 Gnb1 Adcy2 COAGULATION%SMPDB%SMP0000586 Coagulation Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Cat Aldh1b1 Aldh2 Acss1 Acss2 Cyp2e1 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Gars1 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Gaa Ugp2 B4galt1 G6pc1 Pgm1 Gale Glb1 Lct Gla Akr1b1 Hk1 Galt BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Sc5d Cyp51a1 Hsd17b7 Nsdhl Msmo1 Dhcr7 Lbr Dhcr24 Ebp TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Tubb1 Slco1b2 Abcb1a Abcg2 Abcc1 Tuba1b Abcc2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nmnat3 Nmnat2 Aifm2 Nadk Cd38 Nqo1 Nmnat1 Nampt Trp53 Sirt1 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Gls2 Glud1 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh2 Idh3a Ldha Dlst Me1 Slc7a7 Pdhb Idh3b Aco2 Dlat Dld Got2 Mycbp Slc38a5 Slc1a5 Slc1a4 Acly Slc16a1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Rpe Rpia Tpi1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Atp1a2 Clcnkb Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Slc12a6 Slc12a1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Eprs1 Rpl4 Rps16 Rps15a Rps18 Rps19 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Ddc Pnmt Th SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Map2k1 Raf1 Hras Mapk1 Nfkbia Nfkb1 Gngt1 Mapk3 Cxcl12 Plcg1 Pxn Ptk2b Pik3c2g Crk Ptk2 Bcar1 Cxcr4 Gnai1 Gnaq Gnb1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Agt Agtr1a Ace DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Maoa Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Maob Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Aox1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Fbp2 Aldoc Pfkm Tpi1 Hk1 Aldob LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Cyp3a16 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cyp1a2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Agxt Gpt Mpc1 Pcx Aars2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Tnf Map2k6 Map4k2 Map2k3 Tradd Cradd Ikbkb Mapk14 Ikbkg Mapk8 Nfkbia Map3k1 Nfkb1 Chuk Map2k7 Map2k4 Jun Casp2 Ripk1 Tank TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Akt1 Plcg1 Prkca Pik3r6 Plcb1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Hadha Hadhb Hadh Acadl Cpt2 Acaa2 Cpt1a Slc25a20 Acsl1 Echs1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Inpp1 Itpka Nudt4 Ip6k2 Inpp4a Ipmk Impa1 Isyna1 Ppip5k1 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Bpgm Pck1 Pgam1 G6pc1 Gpi Pank3 Pcx Tpi1 Slc2a2 Fbp1 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Aldob PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Grin2a Kcnd2 Cyp2b10 Cyp2a5 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Ugt1a9 Ugt1a5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Chrna3 Atp1b1 Fmo3 Cacnb1 Atp1b3 Atp1b2 Aox1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Maoa Aldh3a1 Aoc1 Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Carns1 Hars2 Aldh2 Ftcd Hal Cndp1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Iars1 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Slc25a11 Got2 Slc25a12 Mdh2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Aldh7a1 Gnmt Mat2a Chdh Dmgdh Shmt2 Sardh Slc44a1 Bhmt Slc44a2 Mtr Shmt1 Mat2b PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C9 Masp2 C2 C4a C8a Mbl2 C3 C5 C6 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca Fasn CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Tyms Ces1d Tymp Cda Slc28a1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rars1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Mpo Cyp3a16 Top2a TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Slc25a11 Pdha1 Mdh1 Mpc1 Pcx Acly Me1 Pdhb CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway P2ry12 Cyp3a16 Cyp1a2 Cyp2c50 Cyp2b10 Pon1 Abcb1a CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Adra1a Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Hadha Hsd17b10 Hadhb Acaa2 Mecr Echs1 Ppt1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Tnf Map2k6 Map2k3 Mapk14 Sos1 Btk Mapk8 Gab2 Map2k7 Fyn Rac1 Il13 Syk Pla2g4a Fcer1a Il4 Il5 Map2k1 Kras Lyn Pdk1 Grb2 Ms4a2 Nras Raf1 Fcer1g Pik3r1 Csf2 Lat Lcp2 Hras Mapk1 Pik3ca Vav3 Akt1 Map2k4 Plcg1 Prkca Map2k2 Inpp5d DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Gls2 Glud1 L2hgdh Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Tktl2 Rpia Gpi Prps2 G6pdx Taldo1 Pfkp Fbp1 Rbks Rpe Pgm1 Dera Pgls SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Creb1 Mapk3 Ikbkb Mapk1 Prkca Nos3 Ikbkg Plcb1 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs Acacb Spcs1 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 Asns ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Gad1 Cdo1 Csad Ado Ggt6 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Slc29a2 Paics Slc28a2 Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Ngf Fgf1 Ccnd1 Chaf1a Hoxb9 Btg2 Rb1 Btg1 Prmt1 Trp53 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1b1 Nos3 Trpv4 Prkg2 Prkg1 Gucy1a1 Trpc7 Kcnq5 Kcnq4 Trpc4 Kcnq3 Gucy1a2 Trpc3 Kcnq2 Adcy10 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp3a16 Cyp2d22 Cyp1a2 Cyp2c50 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Dck Cmpk1 Nme1 Slc22a1 Nt5c Pgk1 Abcb1a Abcg2 Abcc4 Abcc1 Abcc2 Slc22a2 Pcyt2 Pcyt1a Sult1a1 Slc22a3 Abcc3 Chpt1 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Abcb1a Slc6a2 Slc6a4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Ugp2 Pgm1 Ugdh Galk1 Gale Gck Uxs1 Galt ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c65 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Cyp3a16 Abcb1a Pdia2 Sdf2l1 Hyou1 Top2a Mpo Pdia6 Ptgs1 Pdia4 Ppib Dnajb11 Ptgs2 Erp29 Ugt1a1 Hspa5 Abcc3 Top2b OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Gusb Ugt8 Hk1 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification Gsto1 Aqp9 Aqp7 Pnp Slc2a4 As3mt Slc2a1 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Itpk1 Inpp4b Nudt3 Inpp1 Minpp1 Itpka Impa1 Isyna1 Ip6k1 Ppip5k1 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Sars1 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Itpr1 Akt1 Lpar2 Adcy1 Rock1 Srf Gng2 Gnb1 Plcb1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Klb Fgf15 Nr1h4 Fgfr3 Slc10a2 Fgfr4 Fgfr1 Fgfr2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Galm Slc2a13 Pgk2 Aldob Gapdhs PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Sntb1 Abcc8 Cacnb1 Cacna2d2 Cacna1a Scn5a Gcg Slc2a2 Snta1 Sntb2 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Gmds Gmppb Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Hk1 Fbp1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk Pfkfb1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Gngt1 Prkacb Ptgir Myl3 Gnb1 Adcy2 Mylk CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Ikbkb Mapk14 Traf6 Ikbkg Mapk8 Nfkbia Map3k1 Ecsit Tollip Nfkb1 Irak1 Tlr1 Chuk Tlr9 Tab3 Tlr8 Tlr7 Tab2 Tlr6 Tab1 Tlr5 Tlr3 Tlr2 Rela Map3k7 Myd88 Ly96 Cd14 Tirap Tlr4 Map2k4 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Cyp3a16 Abcb1a Abcg2 Pdia2 Sdf2l1 Abcc1 Abcc2 Hyou1 Pdia6 Pdia4 Ppib Bche Dnajb11 Ces2h Ces1d Ugt1a9 Top1 Erp29 Ugt1a1 Hspa5 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Coasy Enpp1 Vnn1 Pank1 Ppcs Ppcdc METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Agt Ace 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Map2k6 Ikbkb Rps6ka1 Mapk8 Nfkbia Map3k1 Bad Nfkb1 Elk1 Chuk Map2k7 Jun Atf2 Arhgef7 Adora2a Pak1 Braf Map3k4 Nfkb2 Prkcz Hras Mapk1 Rap1a Pard6a Pik3ca Rapgef3 Rapgef2 Mapk11 Akt1 Creb1 Gngt1 Prkacb Map2k2 Pdpk1 Gnb1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Itpr1 Prkca Gnaq Plcb1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Hadha Hsd17b10 Hadhb Acaa2 Mecr Echs1 Ppt1 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Tars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Glud1 Pkm Sdhd Sdhc Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Suclg1 Mdh1 Pklr Mpc1 Fh Idh1 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Rpia Gpi Pfkl G6pdx Pgk1 Taldo1 Tkt Slc1a3 Hk2 Gls Slc16a1 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Ugp2 Pgm1 Ugdh Galk1 Gale Gck Uxs1 Galt PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps15 Rps17 Rpl15 Rpl8 Rps20 Rps24 Rps14 Rpl4 Aars1 Rps16 Rps15a Rps18 Rps19 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Tubb1 Cdkn1a Abcc10 Cyp3a16 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Adra1a Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Agt Ace BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Nudt11 Prex1 Ipmk Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Maoa Aldh3a1 Aoc1 Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Carns1 Hars2 Aldh2 Ftcd Hal Cndp1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Cyp3a16 Cyp2c50 Pde4d MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Hadha Hadhb Hadh Acadm Acaa2 Slc25a20 Echs1 Acsm1 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Sult1a1 Chst11 Sult2b1 Suox Papss2 Bpnt1 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Hsd11b1 Akr1d1 Srd5a1 Hsd17b3 Pdia2 Sdf2l1 Akr1c6 Cyp19a1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Cyp11b1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 Cyp2c65 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Pdha1 Idh3g Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Kdr Flt1 Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Ugt1a2 Pdia2 Sdf2l1 Ugt2b36 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Oprm1 Ugt1a9 Ugt2b1 Erp29 Ugt1a1 Hspa5 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Cyp3a16 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cyp1a2 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pcyt2 Pisd Cept1 Chka Ptdss1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Yars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Galm Slc2a13 Pgk2 Aldob Gapdhs LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Itpk1 Vac14 Inpp1 Minpp1 Pik3c3 Pik3r4 Fig4 Ambra1 Pik3ca Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Ippk Impa1 Plcd3 Isyna1 Becn1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2u1 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Hadha Ugt1a2 Hsd17b10 Hadhb Ivd Cyp2b10 Cyp2a5 Acadsb Acsm1 Ehhadh PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Dars1 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Atp1a2 Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Lct Slc2a2 Slc5a1 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Agt Ace METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Sntb1 Scn5a Snta1 Sntb2 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Aldh1a1 Abcc10 Cyp3a16 Cyp2d22 Cyp2b10 Ugt1a9 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Adam17 Egfr Prkca Erbb4 Erbb3 Psen1 Nrg2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Ccnd3 Wasf1 Cdkn1a Pcna Cfl1 Ppp1r12b Pak1 Ccnd1 Actb Cdk5 Myl2 Limk1 Pdgfra Arfip2 Vav3 Ralbp1 Pld1 Mylk Map3k1 Rac1 Cap1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Bpgm Pgam1 G6pc1 Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Gusb Ugt8 Hk1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Tnf Tradd Ikbkb Traf6 Tnfrsf1b Tnfrsf1a Ikbkg Ncoa3 Camkk2 Nfkbia Il1a Map3k1 Il1r1 Map3k14 Nfkb1 Irak1 Chuk Ubc Tab1 Rela Map3k7 Camkk1 Myd88 Tlr4 Fadd Ripk1 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Cyp2b10 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Cyp2c65 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Glud1 Pkm Pcx Sdhc Sdhb Cs EG433182 Pgam2 Pdha1 Idh3g Suclg1 Mdh1 Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Dlst Pdhb Aldob Idh3b Aco2 Aco1 Dld Rpia Gpi Pfkl G6pdx Pgk1 Tkt Slc2a2 Slc1a5 Pdhx Ogdh Slc16a1 CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl4 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Hsd17b1 Cyp19a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Aldh7a1 Bhmt Ahcy Mtr Pemt Mat2b Mat2a Chdh BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs Acacb Spcs1 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Agt Ace ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Cars1 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Agxt Gpt Mpc1 Pcx Aars2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Cyp3a16 Impdh1 Ces2h Ces1d Ugt1a9 Slco1b2 Abcb1a Abcg2 Cyp2c65 Abcc2 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Aldh1a1 Cyp3a16 Cyp2b10 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway P2ry12 Cyp3a16 Cyp1a2 Cyp2c50 Cyp2b10 Pon1 Abcb1a TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Duox1 Tpo Tg Cyba Cybb Nox4 Nox3 Duox2 Slc5a5 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Amigo3 Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Fbp1 Mpi Akr1b1 Sord Pmm2 Aldob Khk Tgds Pfkfb1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Map2k6 Ikbkb Rps6ka1 Mapk8 Nfkbia Map3k1 Bad Nfkb1 Elk1 Chuk Map2k7 Jun Atf2 Adora2b Arhgef7 Pak1 Braf Map3k4 Nfkb2 Prkcz Hras Mapk1 Rap1a Pard6a Pik3ca Rapgef3 Rapgef2 Mapk11 Adcy2 Akt1 Creb1 Gngt1 Prkacb Map2k2 Pdpk1 Gnb1 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Bpgm Pgam1 G6pc1 Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Sst Abcc8 Cacnb1 Cacna2d2 Cacna1a Slc2a2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Irs1 Tsc2 Insr Eif4ebp1 Tsc1 Eif4e Ins2 Akt1 Pik3cg Pik3r6 Irs2 Mtor Slc7a5 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Acat1 Hmgcl Bdh1 Oxct1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling P4ha3 Tlr4 Hif1a Il1b Sirt3 Nlrp3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Cyp3a16 Ugt1a9 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Oprk1 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Creb1 Gngt1 Prkacb Ppp1ca Htr4 Gnb1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Cyp1a1 Sult1e1 Pdia2 Sdf2l1 Hsd17b1 Comt Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Itpr1 Map2k3 Egfr Mapk14 Cacna2d2 Sos1 Mapk8 Map3k1 Elk1 Map2k7 Jun Map2k1 Grb2 Raf1 Cacna1f Cacna1c Cacna1d Hras Mapk1 Cacna1s Map3k2 Pld1 Gna11 Src Fshb Lhb Gnrh1 Adcy1 Prkcb Gnrhr Hbegf Camk2a Cga Cacnb1 Prkca Egr1 Mmp14 Mmp2 Prkaca Actn4 Plcb1 Atf4 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Vac14 Sacm1l Minpp1 Pik3c3 Pik3r4 Cct3 Ambra1 Plcd1 Itpka Miox Ptpmt1 Inpp4a Ipmk Ippk Impa1 Bpnt1 Isyna1 Inpp5j Becn1 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Map2k6 Map2k3 Ikbkb Mapk14 Traf6 Ikbkg Mapk8 Nfkbia Map3k1 Ecsit Tollip Nfkb1 Irak1 Elk1 Chuk Tlr9 Tlr7 Tab2 Tab1 Jun Tlr3 Tlr2 Fos Rela Map3k7 Myd88 Eif2ak2 Ly96 Ppara Cd14 Tirap Tlr4 Map2k4 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Nfatc4 Nfatc1 Nfatc3 Nfatc2 Sos1 Ppp3cc Mapk8 Nfkbia Shc1 Map3k1 Ptpn7 Cd3g Cd247 Nfkb1 Elk1 Cd3d Mapk3 Ubc Fyn Pik3cg Rac1 Ppp3ca Jun Vav1 Ppp3cb Fos Rela Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Pik3ca Zap70 Cd3e Map2k4 Prkcb Plcg1 Prkca MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Slc29a2 Slc28a2 Impdh1 Slc28a3 Slc29a1 Abcc4 Abcc5 Xdh Gmps Rac1 Hprt1 Aox1 Adk Ppat Tpmt FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacnb1 Cacna2d2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Itpr1 Dlg4 Nos1 Xdh Grin2a Aldh2 Prkacb Prkca Ppp3ca Grin1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Glud1 Pkm Pcx Pfkp Sdhd Sdhc Hk1 Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Pdha1 Suclg1 Mdh1 Pgd Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Dlst Pdhb Dlat Tktl2 Aco1 Dld Slc16a4 Rpia Gpi G6pdx Pgk1 Taldo1 Gls Slc2a1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Pdxp Pnpo Aox1 Pdxk Alpl PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Synj1 Vac14 Inpp4b Pik3c2a Pten Pik3c3 Pik3r4 Egfr Pik3r1 Fig4 Cdipt Ambra1 Pik3cd Pip5k1a Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Erbb2 Plcb1 Becn1 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Mpst Ctns Cdo1 Cth Cars1 Gclc Got1 Gclm Ldha BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Slco1a4 Nr1h4 Slc10a2 Gpbar1 Abcc4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Pex14 Crat Phyh Cpt2 Pex13 Abcd2 Aldh2 Hacl1 Slc25a20 Acsl1 Abcd1 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Cyp3a16 Cyp2b10 Pdia2 Sdf2l1 Cyp2c65 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Mc2r Gngt1 Prkacb Pomc Gnb1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Gusb Ugt8 Hk1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Aldh1a1 Cyp3a16 Aldh3a1 Cyp2b10 Cyp2a5 Cyp2c65 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Dlg4 Nos1 Grin2a Prkacb Prkca Ppp3ca Grin1 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Arnt Ahr Hsp90aa1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Map2k1 Grb2 Raf1 Stat5a Rasa1 Srf Hras Egf Stat3 Jak2 Mapk8 Shc1 Map3k1 Elk1 Map2k7 Prkcb Mapk3 Plcg1 Prkca Jun Erbb4 Fos LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Akt1 Adcy1 Rock1 Lpar6 Srf Gng2 Gnb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Gmds Gmppb Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Hk1 Fbp1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk Pfkfb1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Gusb Ugt8 Hk1 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp1a2 Cyp2c50 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a13 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Fbp2 Aldoc Pfkm Tpi1 Hk1 Aldob PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Hars1 Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Cyp2d22 Slc6a2 Slc6a4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Lhb Creb1 Gngt1 Prkacb Lhcgr Cga Ppp1ca Gnb1 Adcy2 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Atp1a2 Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Lct Slc2a2 Slc5a1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Gpi Pkm Pfkp Tpi1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Dgat1 Gpam Gpd1 Lpin1 Agpat1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Dhtkd1 Dld Aldh8a1 Acmsd Dlst BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Wars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Itpk1 Inpp4b Nudt3 Inpp1 Minpp1 Itpka Inpp4a Ipmk Ippk Impa1 Ip6k1 Isyna1 Ppip5k1 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Hsd17b1 Cyp19a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Slc12a3 Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp4a Aqp3 Atp4b Aqp2 Slc8a1 Atp1b1 Atp1b3 Trpv5 Atp1b2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Tnf Mapk8 Gab2 Map2k7 Fyn Rac1 Il13 Syk Fcer1a Il4 Map2k1 Kras Lyn Lck Grb2 Ms4a2 Nras Blnk Raf1 Pik3r1 Csf2 Lat Hras Mapk1 Akt1 Plcg1 Prkca Map2k2 Inpp5d SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Ikbkb Mapk1 Nos3 Ikbkg Mapk11 Nfkb1 Ptgs1 Chuk Creb1 Mapk3 Prkca Sucnr1 Plcb1 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Cyp3a16 Cyp2d22 Sult1a1 Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Casp3 Arhgdib Apaf1 Gzmb Parp1 Jun Arhgap5 Casp8 Casp9 Casp1 Prf1 Arhgap32 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Fbp2 Aldoc Pfkm Tpi1 Hk1 Aldob ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Nars1 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Galm Slc2a13 Pgk2 Aldob Gapdhs INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Hrh2 Creb1 Gngt1 Prkacb Ppp1ca Gnb1 Adcy2 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Lpar3 Itpr1 Akt1 Adcy1 Gng2 Gnb1 Plcb1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Dlat Aco1 Dld Gls2 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) PMC8716518__F11 Extracellular vesicles (EVs) isolated from key time points after burn injury induce differential gene expressions, predicted to significantly impact immune functions in macrophages in vitro RP2 NOA1 TOX PMC8165385__F1 Methylene Blue Application to Lessen Pain: Its Analgesic Effect and Mechanism MB BDNF SIRT1 CP PMC9210989__F3 Significance of PAK4 in signaling and clinicopathology: A review CDC42 TH EGF BAD HGF TRADD GEM EGFR RELB PAK4 GIP PMC4968117__F1 Epidermal growth factor receptor and its downstream signaling pathway EGF EGFR PTEN MTOR PMC7683543__F5 Canonical pathway enrichment analysis identifies immune response classical complement pathway as the ones most enriched in PVEC co-cultured with NPC C4A CR1 CTNNB1 PMC7890860__F4 Signalling pathway and key factors which regulated the mitochondrial energy metabolism in MSCs UCP2 SIRT3 SIRT1 PMC7905242__F4 “瓜蒌-甘草”药对化学成分（）-靶点蛋白（）-信号通路（）网络Chemical components ()-target protein ()-signal pathway () network of "Trichosanthis fructus-Glycyrrhizae radix et rhizoma" drug pair RARA BTK PLAT SHBG CYP2C19 F2 F3 LDLR IL2 ELANE ABCG2 NR1A2 PMC10216619__F4 Possible neurological and mental COVID-19 outcomes related to the angiotensin-converting enzyme 2/Mas/brain-derived neurotrophic factor (ACE2\Mas\BDNF) signaling pathway occupation by SARS-CoV-2 TMPRSS2 BAX BDNF ACE2 IL1B PMC10216619__F2 Adiponectin paradox and its related pathways during COVID-19 infection TMPRSS2 HMGB1 ACE2 PMC4456163__F1 Putative Regulatory Factors Associated with Intramuscular Fat Content MT3 PMC4714843__F7 Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi EGR1 CCL11 SPRY4 IL13 LIF SMAD6 BMP7 CXCL2 IL6 IL5 ID1 ID3 SPRY2 PMC8400885__F10 Benzoic Acid and Its Hydroxylated Derivatives Suppress Early Blight of Tomato (Alternaria solani) via the Induction of Salicylic Acid Biosynthesis and Enzymatic and Nonenzymatic Antioxidant Defense Machinery PMC8950247__F3 Polymorphisms and Gene-Gene Interaction in AGER/IL6 Pathway Might Be Associated with Diabetic Ischemic Heart Disease HMGB1 IL6 SFTPB CNTF ITGAM LMO4 ERAP1 AGER NFKB1 RELA PIAS1 PTPRE IL6ST JAK1 PMC8395431__F1 TNFA and Immune Checkpoint Inhibition: Friend or Foe for Lung Cancer? TRADD REL TRAF2 FADD PMC9408851__F3 Function of N-Myc Downstream-Regulated Gene 2 (NDRG2) as a Negative Regulator in Tumor Cell Metastasis SOCS1 STAT3 MYB NDRG2 PMC11957794__F3 Different types of COL remodeling-mediated signaling pathways STAT3 DDR1 ECD KEAP1 CXCL5 PMC8313969__F2 Macrophages, as a Promising Strategy to Targeted Treatment for Colorectal Cancer Metastasis in Tumor Immune Microenvironment STAT3 EGFR SMAD2 GSK3B SMAD4 PTEN HIF1A MTOR CCL5 CCL2 IL6R CTNNB1 FGFR2 PMC4360066__F6 T-cell activation pathway regulating six key activation genes DOK1 IFNG STAT1 TAGAP FYN BCL10 NFKB1 PMC12078210__F4 IL-21 promotes the formation and maintenance of germinal centers and plays a decisive role in the differentiation of GC-derived B cells into plasma cells BCR PAX5 GC PMC12078210__F2 Pathways of Allogeneic Antigen Recognition and the Impact of IL-21 on DCs CCR7 PMC4213195__F5 Schematic model of Wnt- and SHH pathways working interdependently in GBM based upon observations in this study SHH SMO CSNK1A1 CTNNB1 PMC2238877__F4 PharmGKB Irinotecan Pathway UGT1A1 TDP1 UGT1A3 UGT1A9 CES2 CES1 NFKB1 ABCG2 BCHE ABCC2 ABCB1 PMC6006338__F5 Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids STAT1 STAT2 IRF9 PMC7946814__F1 Sclerostin: an inhibitor of canonical Wnt signaling pathway APC LRP5 LRP6 CTNNB1 PMC11664622__F1 Hepatitis B virus immune tolerance mechanism IRF3 CTLA4 TNF PMC3151419__F6 Regulation of the mTOR signaling pathway by insulin and growth factors RHEB MLST8 TSC2 RICTOR TSC1 IGF1 PTEN MTOR DEPTOR IRS1 PMC11664622__F2 Pathogenesis of liver cancer CDKN1A SUFU APC PTCH1 AXIN1 LRP5 BCL2 LRP6 SMO ADAM10 CTNNB1 PMC3151419__F7 Regulation of mTOR pathway by Sestrins RHEB TSC2 TSC1 SESN1 SESN2 PMC4031321__F1 HIV induction by PKC activators and HDAC and BET inhibitors: NFKB is sequestered in the cytoplasm by IKB TF BRD4 CDK9 BRD2 PMC7677305__F4 Activation of the cGAS-cGAMP-STING pathway mediates obesity-induced inflammation and metabolic disorders TBK1 CGAS IRF3 PMC6117983__F4 Platelet hyperreactivity in type 2 diabetes mellitus VASP COX1 PGR IRS1 PMC6222618__F1 Post-squalene cholesterol biosynthetic pathway EBP SC5D DHCR24 PMC3677135__F6 The canonical Shh signaling pathway SUFU SHH SMO PMC3677135__F7 Wnt signaling pathways APC GSK3B LRP5 PTK7 LRP6 RYK RHO CTNNB1 PMC3677135__F8 Intracellular mechanisms underlying Wnt-induced axon guidance RYK CELSR3 PMC11780521__F5 Metabolic reprogramming in fibrogenic HSCs activation in chronic liver diseases EBP LRP5 XBP1 THRA PCSK9 TREM2 ACAT1 NR1B3 COL1A1 ADAM17 RARB TLR4 LDLR PMC9209730__F3 New Sights Into Long Non-Coding RNA LINC01133 in Cancer SMAD2 GDF15 MSC FOXP2 PMC3577986__F6 Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy APP RGS1 LPP KNG1 YWHAG PMC8042693__F11 PPI network ADH1C HEL-S-117 UGT1A7 PMC3577986__F4 Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy IFNG STAT3 IL10 TNLG1B ATG16L1 LRRK2 ITLN1 IRGM NKX2-3 ZNF365 SLC26A5 PMC9139342__F9 Mediating EGFR-TKI Resistance by VEGF/VEGFR Autocrine Pathway in Non-Small Cell Lung Cancer RHEB EGF TSC2 TSC1 EGFR HIF1A ARHA MTOR KRAS RAC1 PMC3577986__F1 Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy CD226 PPARG DNASE1 TGFBI PDCD1 IL2 IL10 TNLG2B BLK HDAC1 PTPN22 CBL NR2A1 HEL-S-125m C2 FCGR3A SCUBE1 STK16 ERBB2 BCL2 STAT4 LYN TREX1 REL TYK2 SELP PMC3677135__F2 Shh and Wnts guide commissural axons in the vertebrate spinal cord HHIP BOC SHH SMO PMC5991413__F1 Unsolved mysteries: How does lipid peroxidation cause ferroptosis? GPX4 LPCAT3 FACL4 PMC3821792__F2 TLR-4 signaling pathway.Notes: TLR-4/MD-2 complex homodimerization activates the MyD88-dependent pathway and TRIF-dependent pathway IFNG IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC9405250__F11 Polyphenols from Thinned Young Apples: HPLC-HRMS Profile and Evaluation of Their Anti-Oxidant and Anti-Inflammatory Activities by Proteomic Studies POR HMOX1 TXN BACH1 KEAP1 PMC8573346__F8 Iguratimod Alleviates Myocardial Ischemia/Reperfusion Injury Through Inhibiting Inflammatory Response Induced by Cardiac Fibroblast Pyroptosis via COX2/NLRP3 Signaling Pathway GSDMD NLRP3 COX2 IL16 PMC1134985__F3 Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others? CDS1 WEE1 SI CHP1 PMC3779382__F6 Therapeutic modulation of EBV infection and associated signaling pathways BCR MDM2 MTOR PMC11011165__F1 Inappropriate STAT activation in cancer cells BCR EGFR SRC PMC8067185__F1 Induction of EMT by targeting EMT-related genes via activation of the growth factor signaling pathway in pancreatic cancer CDH2 HDAC1 S100A4 HDAC2 MSX2 PMC3179879__F5 Abrin (ABR)-triggered apoptosis BAX ROS1 ABRA PMC4041745__F5 Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome CDC42 TRIO ROCK2 LIMK2 LIMK1 PLAUR GSK3B PLG HEL-S-28 PTEN VAV1 VEGFA SHE RAC1 DOCK1 EIF4E HRAS CRK EIF4G1 PMC4041745__F6 Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome CDC42 ROCK2 LIMK2 EGFR ARHA RHO GRB7 RAI1 FYN TIAM1 FER PAK1 RAP1A PMC3779382__F2 EBV-mediated oncogenic signaling pathway activation in EBV-positive diffuse large B-cell lymphoma of the elderly TRADD TRAF5 CDK2 TRAF1 TRAF3 TRAF2 PMC3115623__F5 Major intracellular signal transduction pathways for CRF1 and CRF2 receptors GRB2 SRC BDNF PMC3617635__F6 CLL-induced Rho GTPase signaling defects in T cells that suppress LFA-1 activation signaling and migration and how this is reversible with lenalidomide CDC42 ARHA RAC1 PMC5884250__F2 Proposed molecular mechanism for maintenance of MSC stemness by cell–cell adhesion through cadherin CDH2 SRC PMC4041745__F4 Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome F2 ARHA TRPC6 TRPC3 BDKRB2 PMC9126990__F1 Biochemical genesis of enzymatic and non-enzymatic post-translational modifications ACLY HEL107 EHHADH FAS ASL GLS PMC3419804__F1 Autophagy, Myocardial Protection and the Metabolic Syndrome RHEB TSC2 TSC1 HEL-S-62p ULK1 PTEN IRS1 PMC5710380__F1 Mast cells and their receptors TLR4 MRGPRX2 PMC11840356__F1 Mitochondrial Dysfunction and Pathways of Apoptosis in Traumatic Brain Injury (TBI) BAX BAD FAS FADD PMC7998465__F7 Molecular regulatory mechanism underlying UA’s anticancer activity in NSCLC cells, and UA’s inhibition of the EGFR/JAK2/STAT3 signaling pathway and PD-L1 STAT3 EGF EGFR PMC4284625__F1 Genetic pathways, prevention, and treatment of sporadic colorectal cancer BAX APC BRAF PMC7716721__F4 SFN-induced ferroptosis pathway GPX4 SFN SLC7A11 PMC12185281__F3 Pathophysiological mechanisms of insulin resistance in the vasculature PDK2 INS PMC4879750__F1 TGFB signaling in fibroblasts SMAD4 NOX4 PMC6087706__F2 Signaling cascades for YAP/TAZ regulation LATS1 MOB1A MOBKL1A LATS2 LIMD1 TEAD2 TEAD3 SRC TEAD4 CTNNB1 PMC4916901__F1 Link between DNA damage and transcription, and pathway of DSB-induced transcriptional repression RNF168 PRC1 RNF8 ATM PMC6366666__F1 TRAIL pathway targeting therapeutics BAX FADD PMC6211039__F2 Unfolded protein response pathways ATF4 EIF2A TRAF2 PMC8233907__F9 Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness CDC2 BAX FAS PTEN MDM2 CCNB1 CCND1 CDK4 PMC6060268__F4 Overlapping actions of metformin and rapamycin RPS6 EIF4B MTOR EIF4E PMC8858883__AF1 Puerarin specifically disrupts osteoclast activation via blocking integrinB3 Pyk2/Src/Cbl signaling pathway JUN SRC PMC4465126__F7 Proposed mechanism by which hyperaldosteronism decreases pulmonary endothelial eNOS activation and nitric oxide (NO•) generation in PAH STAR CYP11B2 NOX4 PMC8307022__F1 Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer TSC2 TSC1 GSK3B PTEN CTNNB1 PMC3814228__F1 Schematic diagram of the adiponectin-AMPK pathway in glomerular cells ADIPOR1 ADIPOR2 USF1 NOX4 PMC5522315__F3 Epithelial-to-mesenchymal transition in the development of endometriosis SMAD2 APC SOX2 GSK3B SMAD4 CTNNB1 PMC3575670__F5 Precursor of myostatin is promyostatin and consists of a propeptide that binds to myostatin noncovalently to form an inactive complex SMAD2 SMAD4 PMC10917964__F3 Schematic diagram illustrating the promotion of bone formation by incorporating Sr2+ on the surface of titanium-based materials SP2 NFATC1 MMP9 CTNNB1 PMC5069446__F2 Nutrients-mTOR-miRNA signaling in skeletal myogenesis MDM2 DROSHA ID1 IRS1 PMC6210148__F1 Topoisomerase 1 reaction and inhibitors TDP1 SSB PARP1 PMC5954027__F1 Selective and non-selective autophagy in CD4 T cells upon T cell receptor (TCR) activation ATG101 ATG10 ULK1 MTOR PMC6186311__F5 Beneficial effect of RC on hepatic glucose and lipid metabolism signalling pathways TG NR1C1 PMC11626780__F5 Immunosuppressive pathways involving tryptophan TDO2 SLC36A4 IDO1 PMC11626780__F6 Intracellular metabolic pathways of BCAAs and the mTORC1 signaling pathway RHEB RPS6KB1 ULK1 POLDIP3 TFEB BCAT1 HIF1A PMC11626780__F3 Glutamine interconversions and metabolic pathways PSAT1 ASNS PRODH PSPH PMC11626780__F4 Urea synthesis pathway involving arginine and PRMT-mediated FLT3 arginine methylation GLDC FLT3 ASS1 ASL KDM4C PMC4681406__F7 Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche through a Unique Signal Transduction Pathway - An Approach for Treating Bone Disease in Diabetes SMAD1 DKFZp781O1323 APPL1 ADIPOR1 MSC MMP9 PMC7068130__F8 Molecular Mechanism of Loss of Function of TLR9 Might Play a Major Role for NPC Susceptibility in Specific Ethnic Groups of NE IndiaSome populations, called “mongoloids,” show a significantly higher incidence for NPC PLSCR1 DGIC PRDM16 TLR9 UCP1 PMC2691147__F1 Hh signalling—a simplified model SUFU PTCH1 SMO PMC11726638__F9 Diagram encapsulates our hypothesis that cytidine/uridine monophosphate kinase 2 (CMPK2) promotes the progression of allergic rhinitis by activating the NLRP3 inflammasome via the mitochondrial DNA (mtDNA)‐STING signalling pathway CGAS NLRP3 CMPK2 PMC3142679__F1 Virus reactivation: a panoramic view in human infections ATF2 MYC PMC3095455__F1 Schematic representation of the apoptosis signaling pathway that indicates existence of three distinct signaling modules in the apoptotic intrinsic pathway BAX PMC8088080__F6 Unraveling the molecular crosstalk between Atherosclerosis and COVID-19 comorbidity TLR4 CXCL2 TRAF6 CXCL8 CXCL3 MYD88 PMC3887612__F5 Tau signaling cascade in LPA induced neurite retraction in differentiated Neuro2a cells LPA ARHA RHO PMC5472377__F6 Pathway alterations diagram integrating gene mutations and copy number alterations to identify pathways altered in UC- and CD-associated CAC EGFR APC BRAF SMAD4 PTEN MTOR MYC KRAS CTNNB1 FGFR2 RB1 CDKN2A TSC2 FBXW7 TSC1 CDK6 CCNE1 NF1 PI3 FGFR1 ERBB2 ATM CCND1 CDK4 PMC3840609__F5 Gonadotropin-releasing hormone (GnRH) signaling pathway containing genes that are represented in the Partial Correlation Information Theory (PCIT) network “growth at the onset of puberty” CDC42 EGFR BTC MMP2 HEL-S-11 PMC5665037__F2 Involvement of lncRNAs in the “adenoma-carcinoma sequence”, multi-step model of CRC pathogenesis EGF EGFR APC PTEN ZEB2 MDM2 MTOR HNRNPK KRAS CTNNB1 PMC3425519__F2 Intracellular vascular endothelial growth factor (VEGF) signal transduction pathway BRAF PTEN GRB2 MTOR PMC4417610__F2 Summary of the HGF/c-Met signaling pathway STAT3 HGF GRB2 SRC PMC12043450__F4 Signaling pathways associated with GH treatment for DOR MAPK1 BAX SIRT3 GRB2 MTOR GHR NOTCH1 PMC6512360__F9 The type I immune response in M FAT10 TH NOS2 IFNGR1 CTSW CST7 STAT2 MMP10 GZMK IRGM CASP12 CTSK IRF1 HIF1A IRF7 IRF8 TNF IFNG STAT1 PMC8546337__F1 Targeting DNA Repair Response Promotes Immunotherapy in Ovarian Cancer: Rationale and Clinical Application TBK1 CGAS GSK3B CXCL10 PMC5578105__F1 Ubiquitin signaling in both sub-pathways of nucleotide excision repair (NER), global genomic (GG-) and Transcription coupled NER (TC-NER), and double-strand break (DSB) repair MDC1 XPC RNF2 DDB2 RBX1 DDB1 CUL4A NEDD4 UVSSA RNF168 CUL4B RNF8 ATM PMC11721126__F1 The development of SARS-CoV-2 induced osteoarthritis EDN1 EDNRA EDNRB TNFSF11 TNF PMC7280757__F3 Complement Membrane Attack Complex GSDMD NLRP3 IL16 RELA RELB VCAM1 CCL5 SMURF2 CCL20 ZFYVE21 PMC5673544__F1 Tandem repeat variation near the HIC1 promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer ERCC1 XPA SIRT1 XPC PMC4657330__F8 Rac1 activation and Wnt synergistically enhance Beta-catenin transactivation in the canonical Wnt pathway APC GSK3B RAC1 PMC9453822__F2 Dietary polyphenols on cancer cell pyroptosis and the tumor immune microenvironment STAT3 CXCL12 CCL22 PMC4081676__F1 Protective role and partial mechanism of peroxisome proliferator-activated receptor A in alcoholic liver disease UCP2 NR1C1 TGFB1 UCP3 CD36 FGF21 SIRT1 PMC7556029__F3 Molecular mechanisms of IL-36R induced tissue fibrosis IFNG NLRP3 CXCL1 CCL2 MYD88 PMC10532080__F8 Knockdown of BAP31 Downregulates Galectin-3 to Inhibit the Wnt/Beta-Catenin Signaling Pathway to Modulate 5-FU Chemosensitivity and Cancer Stemness in Colorectal Cancer SOX2 GSK3B CTNNB1 PMC2917731__F1 Intracellular signaling of FIP1L1/PDGFRA+ (F/P) cells IL5RA CCR3 PMC7522025__F1 Schematics of spiralian embryo, TGFB superfamily cassette and larval Capitella phenotypes SMAD1 DKFZp781O1323 NODAL PMC5642700__F1 Systems biology analysis of longitudinal functional response of endothelial cells to shear stress GPX4 HIF1A CDKN2D HEL-S-97n GPX1 NOX4 CCNH GPX8 PROX1 FOSL2 HEL-S-128m PRDX3 CDK7 CCND2 NFKB1 HEL-S-2a MNAT1 CDK2 VCAM1 HDAC2 CDK4 PMC3325226__F3 A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study UGT1A1 HMGB1 TLR4 RELA IL18 AHR PPARGC1A MYC CP PMC8819670__F1 Hippo pathway consists of distinct oncogenic and tumour suppressive modules LATS1 LPA MOB1A LATS2 TEAD2 TEAD3 ARHA NF2 TEAD4 PMC8819670__F2 YAP/TAZ fusion partners and associated cancers NUTM1 MAML2 CAMTA1 PMC5818424__F7 Hypothetical model for the pathogenesis of glucose intolerance and insulin resistance in TRIM31−/− mice TRIM31 NLRP3 TLR4 IL1B PMC3564490__F3 Proposed alternative pathway of feto-placental androgen synthesis from 17-hydroxypregnenolone POR HSD3B2 SRD5A2 HSD17B3 CYP17A1 PMC3109867__F1 Insulin/iGF-1 signaling pathway is conserved across phylogeny IGF1 SGK1 PTEN PMC9525429__F1 Pattern to Link Adenosine Signaling, Circadian System, and Potential Final Common Pathway in the Pathogenesis of Major Depressive Disorder PER2 PER1 CRY1 PMC5040753__F7 Proposed mechanism of mechanical stretch-induced VSMC hypertrophy demonstrates that the RhoA/ROCK pathway activation, calcineurin activation, NFAT nuclear translocation, and leptin synthesis are involved in this process HEL-S-62p ARHA RHO PMC2863124__F1 DNA damage and replication checkpoints in various organisms CDS1 ATM PMC5294813__F3 Functional network of the interferon signaling pathway by IPA SOCS1 IFNG BAX IRF9 PIAS1 IRF1 PMC9132047__F9 Study on the Mechanism of Sancao Tiaowei Decoction in the Treatment of MNNG-Induced Precancerous Lesions of Gastric Carcinoma Through Hedgehog Signaling Pathway SUFU EGFR DHH SHH IHH SMO MTOR PMC4733656__F5 The Elizabeth River Story: A Case Study in Evolutionary Toxicology AHR AHRR CYP1B1 PMC6482218__F1 The role of molecular genetic markers in cellular stress response FKBP5 NR3C2 MBL2 BDNF TSC22D3 IGF2 NR3C1 PMC4947211__F1 Schematic presentation of gene network implicated in TLR signaling pathway TBK1 TLR9 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 PMC3642686__F4 Schematic description of the MSR IRF3 IRF7 ATF4 EIF2A XBP1 TRAF2 PMC2258669__F3 Enzymatic reactions and assays HPR HEL-S-162eP CP PMC6202076__F0 Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NFKB signaling pathway NFKB1 IKBKB RELA NFKBIA CREBBP CDK2 EP300 MYC PMC2258669__F1 Genomic and functional context of glycerate kinase enzymes in bacteria HPR HP STUM PMC5330810__F1 Inference of Cancer Mechanisms through Computational Systems Analysis APRT GMPR ADA PMC3997009__F1 Routes of presentation of viral peptides on DCs CD40 CD80 PMC8012550__F4 Genome-Wide Association Identifies Risk Pathways for SAPHO Syndrome RAB5C CSF1 SHC1 HEL-S-81p NCF2 FGF21 PIK3CD ASAP1 PRKCZ CTSS PPP3CA INS TUBB6 PPP3CC FGF8 FGF8A CTNNA3 RILP ATP6V1C1 ATP6V1C2 MAP2K6 SPHK2 PDPK1 ITGA2 PRKCA LILRB5 MAPK12 GRIN1 MARCO CYLD PIKFYVE CD209 AMPH MS4A2 IFNGR1 FCGR2B CTSK IL5 RAC1 DOCK1 CRK ITGAM IKBKB PMC5642700__F4 Higher-resolution version of with gene target names visible STAT3 HIF1A FYN CSF2 ADM LAMC2 PRDM1 NOB1 CTSL CTSK NAMPT DUSP4 RSAD2 VEGFA TNF TUBB FOS VCAN LTB ATF3 ENG CEBPA UHRF2 PTHLH FOXO1 AURKB RXRA GNA11 APOB PLTP MUC4 EGR2 CHKA BIK KLF4 TF XPA GFER KLF2 MC1R VASP ERCC2 BLMH LAT CXCL1 NOX4 TEAD4 NR1B3 RARB JUN EGR1 IGF2 PMC4887335__F1 Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes TRADD MLKL TAB3 CYLD FADD PMC5617345__F1 IGF-1R/AKT pathway determines cell fate in response to p53 PML PTMS IGF1R PMC5617345__F2 IGF-1R/AKT pathway determines cell fate in response to p53 IGF1 PTEN IGF1R MDM2 PMC5617345__F3 IGF-1R/AKT pathway determines cell fate in response to p53 IGF1 GSK3B IGF1R MDM2 PMC7404121__F2 Synergistic regulation mechanisms of leaf angle by phytohormones in rice CS BRD2 PMC4891268__F2 Cell-cycle entry regulated by a network of protein regulators TSC2 CDK6 TSC1 MTOR CDK4 PMC4466452__F1 Identified molecular targets involved in ELFEF-induced enhancement of adult hippocampal neurogenesis and osteogenesis MSC RUNX2 CTNNB1 PMC6099685__F7 The potential pathway underlying the anticancer activity of CK in human HCC cells STAT3 EIF2A PMC2814453__F1 Coupling between Akt-mediated cellular energy metabolism, cell survival and proliferation RHEB TSC2 TSC1 PTEN PMC8538975__F4 Transcriptome Analysis for Genes Associated with Small Ruminant Lentiviruses Infection in Goats of Carpathian Breed IFNGR1 CSF3 TNFRSF6B CSF3R IL1R2 IFNG IFNGR2 LY96 CSF2RB PPBP TLR3 TNFRSF13C TICAM1 TLR4 BMP4 IL18 TLR8 RIPK1 TLR7 AMH CCR10 TRAF2 CRLF2 BIRC3 PMC7677787__F2 Lysosomes function as an intracellular signal transduction platform RHEB TSC2 CBL TSC1 GRB2 PMC7432591__F2 Major signalling pathways associated with sarcopenia and peripheral arterial disease (PAD) CRP STAT3 IGF1 MTOR PMC3205276__F1 Biosynthetic pathway of sphingolipids consisting of free long chain bases (top row), which are N-acylated by several CerS enzymes to form dihydroceramides (upper row of octagons) CERS3 CERS5 GAL CERK SMS CERS1 CERS2 PMC3323831__F1 TLR signalling MAL TLR9 CD14 TLR5 IRF3 IRF7 TRAF6 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 FADD PMC8212127__F2 Insulin-Like Growth Factor Pathway and the Thyroid PI3 IRS4 GRB2 IRS1 PMC8212127__F3 Insulin-Like Growth Factor Pathway and the Thyroid IRS4 MDM2 IRS1 PMC3965270__F8 Integration of L-R Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2 CDH2 NODAL DAAM2 GPC3 PITX2 PMC8212127__F4 Insulin-Like Growth Factor Pathway and the Thyroid CD40 IGF1 CD34 PMC8866957__F2 Glimpse of Programmed Cell Death Among Bacteria, Animals, and Plants PURA POR RIPK3 BAX NRG1 CYB ZAR1 GPX4 PMC3421022__F1 The prolactin signaling network in NetSlim PRLR SOCS1 ZAP70 PIK3CA PPIB RAF1 SOS1 SHC1 PXN AGAP2 PIK3R2 PIK3R1 SOCS2 MAPK9 SOCS3 MYC MAPK8 FLNA MAPK3 MAPK14 TEC STAT1 SRC MAPK1 NOS2 FOS IRS1 HRAS PAK1 GRB2 MTOR YWHAG RPS6 JUN RAC1 CBL ITGB1 HEL-S-130P PRL NFKB1 HEL-S-69p RELA CASP3 SIRPA NEK3 JAK1 MAP2K1 CISH GAB2 YWHAZ PMC5597488__F5 Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder TH CA3 DRD1 DRD2 DRD4 BDNF PMC6295076__F7 Hypothesied pathway showing the inhibitory mechanism of cyclin G2 on Wnt/Beta-catenin signaling through Dpr1 CCNG2 APC GSK3B CTNNB1 PMC2659402__F3 Interleukin-31 acts through three signaling pathways: Jak/STAT pathway, PI3K/AKT pathway and MAPK pathway STAT3 OSMR GRB2 JAK1 PMC3418163__F1 The two enzymatic pathways generating inorganic phosphate (Pi) as a result of LPA degradation LPA HEL-S-5 PMC9436575__F6 Preventive Electroacupuncture Alleviates Oxidative Stress and Inflammation via Keap1/Nrf2/HO-1 Pathway in Rats with Cyclophosphamide-Induced Premature Ovarian Insufficiency KEAP1 MAF IL6 TNF PMC8260517__F2 Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities LATS1 LATS2 MTOR PMC5559826__F2 Downregulated genes involved in the insulin signaling pathway in response to the sugar-only diet POR BAD FAS KL PMC5378352__F6 All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma RARA RARB BCL2 FLT1 KDR PMC6406849__F3 LRRFIP1/GCF2 binds to exogenous and endogenous nucleic acids and activates type 1 interferon and pro-inflammatory cytokine responses IRF3 CTNNB1 MYD88 PMC8012063__F4 Status-dependent regulation of Kyoto Encyclopedia of Genes and Genomes pathway hsa050160 Alzheimer’s disease at the cross-tissue level LPL IDE CASP9 BAD REST SIN3A SP1 POC1A BPI CASP12 APOE GSK3B TAF4 UCP1 SNCA HEL70 TNF CASP3 APP TBP BDNF APAF1 HTT FADD PMC4555477__F1 Some sphingolipid fundamentals CERK HEL-S-5 LPP PMC4411553__F4 Current Antiplatelet Treatment Strategy in Patients with Diabetes Mellitus IL1A ITGB3 ITGA2B PMC4580488__F10 A schematic diagram showing the proposed signaling pathway underlying the regulation of ovarian cancer progression by HBEGF/EGFR/YAP/HBEGF and NRG1/ERBB3/YAP/NRG1positive feedback autocrine loops ERBB3 NRG2 NRG1 HBEGF EGFR YAP1 PMC5636111__F4 Novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia JUN EGFR MAPK8 PPP3CC CTNNB1 TCF7L2 FZD4 PDE1A ADCY3 PRKACG PLCB1 CALM1 CREBBP PLCB2 EP300 WNT3 PMC5636111__F5 Novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia RASGRF1 CDC42 GNAI3 GRIN2B PIK3CA GNAO1 MAPK11 FGF14 GRM6 RPS6KA2 AKT3 IL1A TRAF6 HRAS CRK FOXO1 PRKACG GABARAPL2 HOMER2 PLA2G4B SETD7 PMC5094186__F1 (1) Nicotine binds to the nicotinic acetylcholine receptor, causing a conformational change that opens the receptor's ion channel and allowing entry of Ca2+ and Na+ EGF BACE1 NRG3 MTOR SRC PMC10218397__F9 TASE and thymol supplementation in neuronal differentiation and outgrowth effect NAGK MAP2 BDNF PMC9561135__F10 Gut-lung axis: Gut microbiota changes associated with pulmonary fibrosis in mouse models induced by bleomycin TGFBR2 BAX COL1A1 SMAD2 COL3A1 TNF BLM TGFBR1 PMC5746105__F17 Pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury EGF GEM FACL4 NOX4 BTG3 CD83 TFRC PRKCSH WNK4 YBX3 CLU FGF9 CHEK2 SCRN3 KL HEL-S-108 AGA A4GALT CUBN CYLD ARG2 CXADR VWF GLYCTK DCXR CAD EAF2 PSMB8 CALY PLAUR FASN CTH KIT DPYD ARHA TNF FOS NFKBIA CCL20 PMC3660250__F8 Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3B, Neurotrophin-3 and CREB Signaling IGF1 GSK3B PLG IGF1R IGF2 PMC3807000__F2 Autophagy-related common pathway in neurodevelopmental disorders TSC2 TSC1 NF1 PTEN MTOR PMC3834144__F8 Schematic summary of OPRM1 differential signal pathways upon acute and chronic morphine administration RAF1 OPRM1 SRC PMC9040700__F2 High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons STAT1 NLRP3 ACE2 PMC9040700__F1 High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons HMGB1 TLR4 MTOR MYD88 PMC8518784__F9 Curcumin analog GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circular RNA zinc finger protein 83/microRNA‐324‐5p/cyclin‐dependent kinase 16 axis STAT3 PCTK1 PMC11212332__F7 Characterisation of sRNAs enriched in outer membrane vesicles of pathogenic Flavobacterium psychrophilum causing Bacterial Cold Water Disease in rainbow trout SOCS1 SOCS3 EEA1 PMC3616967__F4 Proposed model for iAs-induced birth defects via the GR pathway STAT3 NOS2 FAS PXN SMAD2 NR3C1 CTNNB1 VHL RB1 RELA NFKBIA CASP3 BCL2 CCND1 PMC7222031__F2 PVR’s role in immunomodulation CD96 HEL-S-92n TIGIT NECTIN2 PMC2810629__F1 Tale of Transforming Growth FactorB (TGFB) Signaling: A Soigné Enigma MAP3K7IP1 SMURF1 SMAD2 GSK3B SMAD4 ARHA TRAF6 PMC5746105__F16 Pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury MLYCD CSA2 ELOVL2 SERPINF2 ACSL3 DDOST VAV2 SOAT2 IL3RA KDELR3 CD46 SLC27A2 MGLL FAIM CSTB PRKAA1 LXN ACSS2 ABHD2 GOSR2 CEBPG MTTP CFI MGST2 PTS C9 A2M WNT4 FDPS CD163 MARCO GHR ABCC2 PKLR CYLD EPHX2 PRG4 NMI ACSF2 MSRA CCS ID2 CAPZA2 GCLM APOE C7orf24 HRG HAMP GSTM5 NEDD4 BCL2 EHHADH CXCL12 CS IFNGR2 PRKCSH VWF ADIPOR2 SERPINE2 ACSM3 AQP9 DBI C8A LIPE ACADL ENPP2 ASNS TNFSF10 LBP HEL-S-1a PMC10379122__F1 Unravelling the Role of P300 and TMPRSS2 in Prostate Cancer: A Literature Review TMPRSS2 SHBG ERG PMC7287266__F1 Retinal Degeneration Caused by Rod-Specific Dhdds Ablation Occurs without Concomitant Inhibition of Protein N-Glycosylation DHCR24 DPAGT1 NUS1 MVK HMGCS1 ALG5 SRD5A3 ACAT1 IPP DOLK HMGCR ACAT2 DHDDS DPM1 PMVK MVD DHCR7 FDPS FDFT1 PMC4147692__F3 Apoptosis induction by the HIV-1 envelope protein at the cell surface CDC2 BAX MTOR CXCR4 PMC9205467__F1 Ferroptosis in Chronic Liver Diseases: Opportunities and Challenges TF IREB2 SLC3A2 KEAP1 GPX4 FACL4 SLC7A11 NF2 HEL-S-64p HEL-75 ADA PMC4147692__F1 Involvement of HIV proteins in intrinsic apoptotic pathways: The viral proteins are marked in yellow BAX ATR BAD FAS RAF1 ATM PTEN APAF1 PMC8524328__F4 Exploration of the existing and candidate crosstalk between the diagrams of the COVID‐19 Disease Map COMP JUN PYCARD MAVS ITCH INA RELA ARHA MYC INS FOS PMC8524328__F5 Interferon type I signalling pathway diagram of the COVID‐19 Disease Map integrated with TF activity derived from transcriptomics data after SARS‐CoV‐2 infection ENG JUN INA IKBKE RELA TANK TLR7 PMC10603981__F1 Signaling pathways involved in ferroptosis SLC3A2 GPX4 FASN FACL4 NUPR1 SLC7A11 SQSTM1 ACACA PMC7067901__F2 Top three molecular networks identified by Ingenuity Pathway Analysis: (A) Network 1 TRRAP TRPS1 SFRS8 SLMAP YEATS4 MYLIP DST ZMYM4 PMC10603981__F2 Necroptosis signaling pathways RIPK3 FAS ZBP1 TRADD TLR3 MLKL RIPK1 TRAF2 PARP1 FADD PMC3290617__F1 Decrease of miR-146b-5p in Monocytes during Obesity Is Associated with Loss of the Anti-Inflammatory but Not Insulin Signaling Action of Adiponectin INSR IRAK1 TRAF6 IRAK4 IRS1 PMC5145761__F3 Displays canonical BMP pathway identified through Ingenuity Pathway Analysis (IPA) SMAD1 DKFZp781O1323 SMAD4 RUNX2 PITX2 SMURF1 FST NOG GREM1 TLX2 CAMK4 GRB2 NKX2-5 HOXC8 PMC3372896__F1 Central role of Beta-catenin in Wnt signaling and the cadherin complex APC GSK3B LRP5 LRP6 TEF CTNNB1 PMC5145761__F1 Displays canonical IL-1 signaling pathway identified through Ingenuity Pathway Analysis (IPA) ECSIT JUN TRAF6 UNK MYD88 PMC7425198__F6 Effective Method for Accurate and Sensitive Quantitation of Rapid Changes of Newly Synthesized Proteins RBMX SRSF7 RAN RBM22 CCL5 PRKCSH IL1B SF3B2 DDX5 NUP107 B4GALT1 TUSC3 RPL34 RPLP0 SEL1L AKAP8 RRBP1 YBX1 PTGS2 TNF RLF NUP160 RPL6 CHCHD3 RPL15 SRSF10 SEC63 ZNF384 HMGA1 RPL13A NUP153 RELA PLRG1 ALG1 RPS25 DNAJB11 DNAJA2 EGR2 HNRNPC CCL20 STT3B NUP98 PMC8476871__F1 NFKB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites CD40 LTBR TRADD RELA RELB TRAF6 TNF FADD MYD88 PMC8476871__F2 NFKB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites TLR1 GAL TIRAP TLR4 TLR9 HEL-S-28 MYD88 PMC9231801__F2 Three stages of immunological pathway leading to mortality in COVID-19: Stage I (Initiation), with early induction of predominant chemokines upon SARS-CoV-2 infection and viral sepsis CCL3 CCR5 CCR2 IL1A CCL5 CCL2 TNF PMC4487446__F7 Scheme illustrating the signaling pathway involved in the production of chemokines and cytokines induced by prostaglandin F2A (PGF2A) IL6 CCL2 CXCL8 IL1B PMC4203832__F4 Whole Proteome Analysis of Mouse Lymph Nodes in Cutaneous Anthrax CDC42 JUN MARCKS EPO HAMP HIF1A MAP3K11 ATF2 MYC UNK PMC5336598__F1 Role of the unfolded protein response (UPR) in cancer ATF4 EIF2A PMC4741987__F8 ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription SP1 C1QBP ZNF32 PMC2631600__F1 The HMGCR pathway HMGCR SC5D DHCR7 PMC6721423__F1 PTEN-mediated control of cancer stem cells (CSCs) hallmarks BMI1 STAT3 S100A4 GSK3B PTEN IL6 MTOR CXCR4 PAX7 IL6R MAOA PMC8809122__F9 Epigallocatechin gallate enhances human lens epithelial cell survival after UVB irradiation via the mitochondrial signaling pathway BAX PMC8471358__F1 Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives STAT3 IGF1 TLR4 SMAD2 SMAD4 IGF1R MTOR PMC3867867__F3 Genetic determination of testes in Japanese medaka fish, chicken, and mouse DMRT1 WT1 FOXI2 FOXL2 SOX9 SRY FGF9 WNT4 AMH PMC4104517__F2 Cell Death and Survival Through the Endoplasmic Reticulum-Mitochondrial Axis BAX AK2 MFN2 PMC5882778__F2 Systemic metabolic cues with Kisspeptin, orexigenic, and anorexigenic neurons POMC PC NPY AgRP PMC5971270__F5 IPA identified “LXR/RXR activation” as the canonical pathway in the ESPs of TC-1 cells with the highest predicted potential/significance affected by the treatment with caerin 1.9, predicted based on label-free quantitation LPL LY96 CD36 IL16 IRF3 ABCG4 APOA5 PMC9083176__F1 Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury RHEB MAF1 TSC2 TSC1 PTEN HEL-S-44 PMC5971270__F4 IPA identified “Tec kinase family signalling” as the canonical pathway in the cells with the highest predicted potential/significance of being affected by the treatment of caerin 1.9, based on iTRAQ data SCEL FAS FOS FADD PMC7279457__F2 Positioning Cx43 in the intercellular coupling by channels in the DC-T cell IS PANX1 CD80 APC PMC6683209__F1 Cyclin D1-CDK4/6-RB pathway and crosstalk in breast cancer TSC2 CDK6 EGFR CDK2 MTOR CDK4 PMC10474074__F2 Kennedy pathway and Lands cycle in ferroptosis LPA GPX4 LPCAT3 FACL4 PMC6429175__F8 Comprehensive pathway of Alzheimer’s disease derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG) LPL IDE CASP9 DCC BAD FAS CASP8 CASP12 APOE GSK3B SNCA TNF CASP3 APP APAF1 FADD PMC9611857__F2 A Pathological Interaction between Beta-amyloid and Mitochondria in the Occurrence and Development of Alzheimer’s Disease FIS1 OPA1 MFN1 MFN2 PMC9112566__F1 Endomembrane remodeling in SARS-CoV-2 infection TMPRSS2 CTSL ACE2 PMC3372896__F3 Intersection of pathways controlling Wnt/Beta-catenin signaling and cadherin-mediated adhesion EGF FER FGFR1 SMAD4 SRC CTNNB1 PMC3555267__F2 Typical MAPK signaling pathway MAPKAPK2 RHO PMC8147076__F1 Bioengineering of Genetically Encoded Gene Promoter Repressed by the Flavonoid Apigenin for Constructing Intracellular Sensor for Molecular Events AIP AHR PMC5187837__F1 The integrin outside-in signaling BAD ARHA MTOR RAC1 PMC2917906__F1 HIF-1A and HIF-2A have different functions in the cartilage RELA ADAMTS5 IHH RUNX2 PMC11671575__F1 Signaling pathway of FOXF2 in tumor progression TF ID2 EGFR BTC SMAD4 FOXF2 ZEB2 AREG VGLL4 IRF2BPL CTNNB1 PMC8268527__F1 Targeting NEDDylation as a Novel Approach to Improve the Treatment of Head and Neck Cancer UBA3 NEDD8 CAND1 PMC8034822__F4 Divergent cytokine pathways drive fibrosis IL25 TSLP TNF PMC8151747__F1 Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis tal-1 TK1 HEL-S-68p HEL-S-49 PDC PMC8151747__F2 Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis tal-1 TK1 PMC5954996__F7 BACTEROIDES FRAGILIS TOXIN COORDINATES A PRO-CARCINOGENIC INFLAMMATORY CASCADE VIA TARGETING OF COLONIC EPITHELIAL CELLS STAT3 APC CTNNB1 PMC7773148__F1 Fatty acid and endocannabinoid metabolism by cytochrome P450 classes CYP2J2 CYP2C9 CYP2C8 CYP4F2 CYP4F3 CYP4F12 PMC5133730__F7 Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway AQP2 AVP PMC11044490__F6 DEGs in plant hormone signal transduction pathway TF BIN2 EBF2 PMC7494970__F2 Involvement of Ang-II, ACE2, and Ang-1–7 in atherogenic pathways NOX5 ADAM17 ARHA ACE2 NOX4 PMC4779544__F1 Proposed pathway connecting HMGB1, TLR4, TLR2, MyD88, and TRIF signaling to inflammation and regeneration following muscle ischemia HMGB1 TLR4 MYD88 PMC4409274__F7 Cancer activates Stat3 in muscle to stimulate loss of muscle mass via two signaling pathways STAT3 SMAD2 PMC8957418__F3 Progress of Statin Therapy in the Treatment of Idiopathic Pulmonary Fibrosis TGFA ARHA RHO PMC4646237__F9 Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway IGF1 F2 IRS1 PMC10854933__F2 An illustration of the theoretical modes of action of the MRGPRX2 signaling pathway inhibitors ORAI1 MRGPRX2 LYN SRC PMC3689254__F2 General scheme of EGFR activation EGFR PTEN MTOR PMC3689254__F3 EGFR activation of the Ras/Raf/MEK/MAPK pathway EGFR ATF2 GRB2 FOS PMC3689254__F6 Several flavonoid compounds also target the Fyn/Src signaling pathway STAT1 FYN PCNA COX2 ATF2 SRC PMC9526582__F10 Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer DDR1 CD36 FABP1 C1R CILP NUMB PSG1 LYN LRRC32 VEGFA PCK1 FLNA PMC9348576__F2 Products of deregulated genes in Dp(16)1Yey/+ are enriched in proteins linked to glutamate receptor signaling pathway and in proteins involved in an ARC–PSD95 complex linked to ID and intelligence SHANK3 HRAS ARHGAP32 GDA PMC9526582__F13 Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer CD36 PCK1 PMC7758035__F5 GA biosynthesis and inactivation, highlighting the GA signal transduction pathway that enables GA homeostasis TF TPR ERF PMC5036257__F7 A new SLIT/miR-218/(NFKB/POU2F2/ROBO1) signalling pathway promotes gastric cancer (GC) metastasis SLIT3 SLIT2 POU2F2 PMC9512455__F7 Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice BAAT CYP7A1 PMC3317641__F7 Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated Genes SOX9 OSMR FKBP1A PLAUR FOXC1 GADD45B SFN AMFR TAP2 ASNS DUSP14 TNLG2B PMC6501790__F2 Epigenetic control and the circadian clock: linking metabolism to neuronal responses STAT3 NAMPT NHLH2 SIRT1 PMC8471000__F2 Metabolic Reprogramming and Host Tolerance: A Novel Concept to Understand Sepsis-Associated AKI SIRT1 SIRT6 PMC3317641__F6 Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated Genes LTBP2 KLF4 EMP2 KRT5 UGT1A3 THBS1 ETS2 ADM TAF5L KLF6 KRT14 SPRR1B MYC HMGCS1 PSAT1 PMC6743121__F8 Schematic depicting HSPA5 protects against DHA-induced ferroptosis in glioma cells GPX4 ELF2 HEL-S-89n ATF4 EIF2A PMC6297832__F6 Proposed mechanisms of anthocyanin’s effect on NVU dysfunction after ischemic stroke BAX BAD NLRP3 PMC10531065__F8 Antitumor Effect of the DNA Polymerase Alpha Inhibitor ST1926 in Glioblastoma: A Proteomics Approach FASN ANXA1 CBX3 HEL-S-30 RPA1 HEL-S-34 PROX2 DEK HEL-S-47e MTHFD1 PADI2 HYOU1 PHGDH EIF3C SLC25A6 YWHAZ PMC4539601__F4 Inferred network models capture oncogenic signaling pathways in melanoma TSC2 ATR STAR PCNA RS1 BRAF SRC CTNNB1 PMC8292951__F1 RNA Methylation in Systemic Lupus Erythematosus SOCS2 METTL14 IL2 IL7 SOCS3 METTL3 CISH ASB2 PMC5554748__F8 Cofilin Mediates LPS-Induced Microglial Cell Activation and Associated Neurotoxicity Through Activation of NFKB and JAK-STAT Pathway STAT1 COX2 TLR4 SRC IL1B MYD88 PMC8975241__F1 Effect of PD-1 on T cell-mediated signaling pathways and metabolism ZAP70 FAS FYN APC NFATC1 MTOR CPT1A LCK PMC8975241__F2 Metabolic effects of PD-1 ablation or blockade in effector (Teff) and regulatory (Treg) T cells NFATC1 MTOR SRC PMC4539601__F2 Cluster-guided pathway analysis of the response map HEL164 C6 ATR JUN BAD PCNA HEL-S-62p EGFR EBP BRAF CTNNB1 C2 COX2 RS1 BCL2 ATM SRC PMC9601210__F7 Therapeutic Targeting of NFKB in Acute Lung Injury: A Double-Edged Sword SYK RELA PMC7014257__F2 Strategies to overcome anti-angiogenic therapy resistance CCL18 EPHA2 VEGFA PMC4906396__F5 Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes STAR OSM PMC3474186__F3 Apoptotic signaling through tumor necrosis factor superfamily receptor 6 (Fas) and tumor necrosis factor receptor (TNFR) CASP9 FAS TRADD CASP3 APAF1 TRAF2 IL1B FADD PMC3474186__F4 Signaling pathways mediated by rat sarcoma (Ras) and protein kinase B (Akt) CASP9 CASP3 PTEN MDM2 MTOR PMC8082996__F9 Serum-derived exosomes containing NEAT1 promote the occurrence of rheumatoid arthritis through regulation of miR-144-3p/ROCK2 axis ROCK2 CCND1 CTNNB1 PMC7654839__F1 Optogenetic tools for remote activation of intracellular Ca2+ signaling CAD ORAI1 OCA2 STIM1 PMC4021255__F3 Ingenuity Pathway Analysis of genes negatively regulated by unliganded GR CXCL12 ST6GAL1 SPARC AIP PLCL1 TWIST2 SULF2 EFNA1 SMPD2 THRA MMP11 C1QTNF2 ITGB6 BCL2L1 PMC4021255__F4 Ingenuity Pathway Analysis of genes positively regulated by unliganded GR PRLR ID2 HEL-S-62p IRF9 NR3C1 RTP4 COLEC12 CD74 STAT5B CCND2 SP100 USP18 OASL CH25H P2RY6 TMSB4X DNASE2 AID CP TMSB10 PMC2938637__F2 Current model of early symbiotic signaling pathways NUP133 NUP85 PMC5302036__F3 Switching off malignant mesothelioma: exploiting the hypoxic microenvironment RAD52 CDKN2A UBA7 MSH2 AXL CCND2 HEL-S-133P HK2 EGFR BAP1 MTOR CCNB1 PMC8534876__F8 Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration BAX LIMK2 SUN1 RHO PMC8560683__F1 Klotho as Potential Autophagy Regulator and Therapeutic Target IGF1 BCL2 MTOR PMC8534876__F3 Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration SHH PC RAC1 PMC8841529__F6 Immediate-Early, Early, and Late Responses to DNA Double Stranded Breaks SHLD1 RNF168 CTC1 STN1 TEN1 RIF1 SHLD3 SHLD2 PMC4870238__F1 Signal transduction pathways that mediate Treg resistance converge on the PI3K/Akt pathway STAT3 TLR1 TLR4 TRAF5 TLR9 TLR8 TRAF1 TRAF3 TRAF6 TNF TRAF2 MYD88 PMC2797270__F8 Summary of Trif-biased signaling and selective p38 activation by sMLA TBK1 TLR4 MAL CD14 IRF3 LBP MYD88 PMC8648636__F2 Drug combination screening as a translational approach toward an improved drug therapy for chordoma EGF HGF TGFA EGFR PTEN MTOR PMC8841529__F1 Immediate-Early, Early, and Late Responses to DNA Double Stranded Breaks ERCC1 RAD52 PCNA RIF1 MDC1 BLM SSB BARD1 L3MBTL2 MCM7 LIG1 MRE11A BRCA1 RNF168 CDC45 PAXX GC RNF8 MCM3 MCM5 ATM MCM6 MCM2 PMC11594856__F1 Signaling pathway of CTLA-4 CD80 PMC8946661__F5 Systematic Review to Define the Multi-Faceted Role of Lysine Methyltransferase SETD7 in Cancer TP73 CCNE1 SHH MMP2 VEGFA SUV39H1 CCND1 TWIST1 SETD7 GLI3 PMC9027775__F5 Human RelA Transgene on Murine Macrophage Inflammatory Responses PPARG OSM TEC BCL2L1 MAF SRC IRF1 IL1A VEGFA CXCL10 FOS CEBPA CDKN1A EDNRB CXCL9 KDM1B HEL113 SLC40A1 TNFAIP3 UBE2L6 GEM MSMO1 IFIT1 IFIT3 IFIT2 FLCN DHX58 NCK2 VSIG4 TRIM21 TGFBR1 HAVCR2 GBP5 IL1R1 CD300A RIPK2 FRMD4B TUBB2A PPP1R15A CEBPD HAAO AHR CSTF2 NOD1 RAB11FIP1 POLR2A GBP2 CCL17 GBP3 SPEN CAV2 PYHIN1 NR1H3 CGN SELE SLC4A7 SQLE SPSB1 MAFB FABP4 PTGS2 SDC1 SPSB4 MAD2L1 CBL PMC7094200__F3 Other signaling mechanisms regulated by RSV in a DCM heart UCP2 KEAP1 TLR4 FGF2 PMC9640784__F2 Select mechanisms of HER2-targeted resistance CD44 CDK6 CDK2 MUC4 MTOR CCND1 CDK4 PMC3242881__F6A Src REGULATES SPHINGOSINE-1-PHOSPHATE MEDIATED SMOOTH MUSCLE CELL MIGRATION S1PR1 S1PR3 GSK3B SRC PMC8466012__F3 Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism KLF4 HIF3A HK2 SOX2 HEL-S-30 MYC PMC8466012__F4 Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism PDK4 HIF1A PMC5494602__F9 Model of TRAF3-dependent regulation of RIG-I signaling pathway by NS1/126-225 TBK1 MAVS TRIM25 IRF3 TRAF3 PMC8194041__F2 Stem cells in the treatment of renal fibrosis: a review of preclinical and clinical studies of renal fibrosis pathogenesis SMAD2 SMAD4 ZEB2 PMC3876432__F3 IL-6-STAT3 signaling and premature senescence STAT3 IGFBP5 NFKB1 RELA IL1A CXCL8 PMC2785637__F1 Schematic overview of hepatic lipid biosynthetic pathways TG PSD PEMT PMC4065097__F1 Simulation of Swanson's Literature-Based Discovery: Anandamide Treatment Inhibits Growth of Gastric Cancer Cells In Vitro and In Silico GRAP2 MAPK1 STAT3 TCEAL1 CDKL1 CD14 CDKN2D PTGS2 FOS HEL-S-102 DAPK2 NDUFA2 AHSA1 CYP3A4 GJA1 IL23A PMC7445477__F7 Troxerutin on vascular inflammatory mediators and expression of microRNA-146a/NFKB signaling pathway in aorta of healthy and diabetic rats IRAK1 IL6 TRAF6 IL1B PMC3594312__F5 Inactivation of DNA–Dependent Protein Kinase Promotes Heat–Induced Apoptosis Independently of Heat–Shock Protein Induction in Human Cancer Cell Lines KLF4 SOCS1 JUND TRAF3IP2 TNFRSF10B SLC1A3 NR1D1 PLAUR CYCS IRF1 VEGFA TRAF6 IPP RIPK2 AHR APP ATF4 EGR2 TRAF2 BIRC3 PMC3766771__F1 Transcriptional regulation of effector and memory CD8+ T cell fates STAT3 TSC2 KLF2 TSC1 FOXO1 ELL IL21R STAT4 CD133 SOCS3 MTOR PMC6198389__F3 Possible therapeutic strategies for cancer stem cell elimination CD44 MTOR ABCG2 CTNNB1 PMC3766771__F2 Transcriptional regulation of effector and memory CD8+ T cell fates CD80 PRDM1 PMC2287285__F7 Comparison models summarizing how eIF4E is not only downstream of the PI3K–AKT pathway (left) but can modulate this PI3K–Akt axis through NBS1 (right) CCNE1 PML CCNA2 MDM2 CCNB1 CCND1 EIF4E PMC12144634__F4 Cell cycle proteins: Linking the cell cycle to tumors CDC2 ATR WEE1 CDK2 ATM PLK1 PMC9603526__F2 Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease DAO PMC4355290__F5 Changes in Protein Expression in Two Cholangiocarcinoma Cell Lines Undergoing Formation of Multicellular Tumor Spheroids In Vitro ALB HEL-S-99n EZR HEL113 SERPINB5 HSPD1 HYOU1 HEL-S-125m BCR HEL-S-162eP KRT19 PMC3478445__F12 Model of Stat3, Ascl1a, and Lin28a in inducing maximal Müller glial proliferation in the light-damaged zebrafish retina STAT3 HBEGF LIN28A PMC8473751__F6 Insight in the Recent Application of Polyphenols From Biomass FOXC2 HEL-S-68p E2F3 CXCL1 MMP2 PTEN CXCL2 MMP9 SIRT1 PMC8473751__F3 Insight in the Recent Application of Polyphenols From Biomass GCLM NQO1 NGB PMC7666735__F8 Mechanisms contributing to RES inhibiting the metastatic potential of cervical cancer cells CDH2 STAT3 MMP3 JAK1 TWIST1 PMC7072286__F6 Venn diagram illustrating differential molecular pathways in recGB vs ERCC1 XPA CD80 ATR PCNA ATM ITK KRCC1 MDM2 POLE MBD4 MGMT TREX2 HUS1 MSH6 RAD50 RAD51 MSH2 MSH3 CTLA4 BARD1 MRE11A BRCA1 TREX1 CHKA LCK PMC11897911__F6 PGAM5 activating NFKB signaling pathway to promote polarization of M1 macrophages PGAM5 MTOR TNF PMC7547764__F1 c-MET/HGF pathway in gastric cancer pathogenesis HGF EGFR GRB2 MTOR SRC PMC7897492__F6 Working Model H2AX RNF169 DYRK1B POLI PMC9250438__F6 Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types STAT3 HGF MMP2 PTPRT PMC9437119__F8 Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics FIS1 MIF MFF TBC1D15 PMC5605936__F1 Antiviral apoptotic pathways BAX TBK1 TRADD TLR3 RIPK1 IRF3 FADD PMC4611218__F3 Effect of oral foreign plasmid pcDNA3 on complement activation classical pathway MASP1 C6 RAN HEL-S-62p C9 SET PMC155392__F3 Predicted pathways for degradation, transport, and metabolism of chitin by M NAGA CP PMC4611218__F2 Effect of orally administered foreign plasmid pDNA3 on proteasome degradation pathway IFNG HEL-S-71 UBE2H RPN2 UBE2R2 UBE2B UBE2D2 UBE2E3 RPN1 UBE2E1 UBE2A SET PMC8124914__F2 Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy VASP ARHA RHO PMC4581061__F3 Induction of the extrinsic pathway of apoptosis by phthalates FAS SP1 PMC8902906__F3 Biological and multifunctional roles of IL-38 in different infectious diseases and COVID-19 IFNG CXCL1 CCL20 PMC3514880__F3 Genome sequences of wild and domestic bactrian camels CBL INSR FOXO1 GRB2 PDK2 MTOR INS PMC9156568__F15 Characterizing the Propagation Pathway of Neuropathological Events of Alzheimer’s Disease Using Harmonic Wavelet Analysis LAT POLE INS PMC5571732__F1 Methionine metabolic pathway HEL-S-61p MTR MAT1A PMC3924811__F2 Mechanosignaling in Bone Health, Trauma and Inflammation JUN COX2 SRC RUNX2 FOS PMC4526774__F2 Pim signaling in MM RHEB MAX TSC2 BAD MYC ELF3 EIF4E PMC8046019__F1 Ghrelin-induced effector pathways and unavowed signaling hotspots RHEB LEAP2 ULK1 SMAD2 SMAD4 MTOR SRC GHR SIRT1 PMC3512188__F3 Roles of miRNAs in DNA damage response CDC42 PPM1D H2AX ATM MDM2 SIRT1 PMC8199999__F1 Minor Intron Splicing from Basic Science to Disease ZRSR2 STK11 ZNF547 RNPC3 PMC8199999__F6 Minor Intron Splicing from Basic Science to Disease GEMIN2 GEMIN5 PHAX SMN1 INS PMC8718186__F1 cGAS‒STING signaling and function in metabolism and kidney diseases TBK1 CGAS IRF3 PMC8161298__F1 TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis SOX2 TERT PMC3857355__F8 Therapeutic strategies that have been used to target the TGFB signaling pathway to reduce scarring SMAD2 SMAD4 PMC3163574__F2 Identification and Visualization of CD8+ T Cell Mediated IFNG Signaling in Target Cells during an Antiviral Immune Response in the Brain IFNG STAT1 IFNGR2 IFNGR1 JAK1 PMC3430731__F1 Signaling pathways regulating lipogenesis in cancer cells FASN MAL TIGAR MTOR AKR1B10 MYC SLC38A5 PMC4359552__F1 Conceptual model of general lifestyle effects, salient CHD pathogenetic pathways and CHD hallmarks TF NLRP3 IGF1 VCAM1 MIF BDNF TNF MPO PMC11570929__F4 mTOR signaling pathway and cellular senescence PRR5 RHEB TSC2 TSC1 DEPTOR CCND1 CDK4 PMC11570929__F5 Insulin-like signaling pathway and cellular senescence RHEB STAT3 TSC2 TSC1 MTOR JAK1 IRS1 PMC8161298__F7 TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis MDM4 CTCF LATS2 PTMS MDM2 PMC3857355__F3 TGFB/Smad signal transduction pathway SMAD2 SMAD4 PMC8738154__F5 Molecular characteristics and clinical outcomes of patients with Neurofibromin 1-altered metastatic colorectal cancer EGF NF1 EGFR PTEN MTOR PMC3757373__F1 Methionine metabolism in liver TH HEL-S-61p PMC5865700__F1 Shh signaling pathway SUFU SHH SMO PMC9218565__F1 Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy CD44 STAT3 NNMT CDK12 SP1 BRCA1 MMP2 NAMPT MTOR PMC4273979__F1 Pikromycin and methymycin biosynthetic pathway in Streptomyces venezuelae ATCC 15439 NME2 tmp_locus_29 HEL-S-5 PMC3315683__F1 Phosphatidylinositol 3-kinase signaling pathway RHEB INPP4B PTEN PMC3682211__F7 Aspirin targets multiple components of the AMPK/mTOR signaling pathway in colorectal cancer TSC2 TSC1 MTOR PMC9484965__F9 Quantitative Expression of SFN, lncRNA CCDC18-AS1, and lncRNA LINC01343 in Human Breast Cancer as the Regulator Biomarkers in a Novel ceRNA Network: Based on Bioinformatics and Experimental Analyses BAX BAD IGF1 MDM2 PMC3828604__F1 Interactions of stress proteins and cell surface TLR signaling pathways TBK1 TLR4 HSF1 IRAK1 ATM IRF3 ATF4 TRAF3 TRAF6 XBP1 MYD88 PMC6767494__F1 Management of cancer by fecal microbiota transplant STAT3 TNF CTNNB1 PMC3828604__F3 Stress proteins in crosstalk with cytoplasmic PRR signaling TBK1 NOD2 IRF3 IRF7 NOD1 ATF4 TRAF3 PMC6480560__F1 Transcriptional changes of type I interferon (IFN-I) signaling pathway members in the cerebellum of canine distemper virus (CDV)-infected compared to control dogs STAT2 IRF9 IRF1 IRF3 IRF7 MYD88 STAT1 TLR3 OASL MX2 MX1 TLR7 ISG15 JAK1 OAS1 TYK2 OAS2 PMC11855671__F6 Biosynthetic and signal transduction pathways of SA HPD NPRC PMC6498735__F1 Regulatory pathways leading to stem-like cells underlie prostate cancer progression CD44 FOXA1 MYC PMC3621568__F1 TGFB transduces signaling through Smad and non-Smad signaling pathways JUN SMURF1 SMAD2 SMAD4 ATF2 PMC1998884__F1 Pathways involved in GSIS PGP CIC MAL PDC PC CS PMC8085809__F2 Microbiota signalling to the host circadian and metabolic systems occurs via both contact-dependent mechanisms and contact-independent mechanisms FAS IF2B1 PYY NF2 PMC3209802__F1 Assembly of checkpoint and repair machineries at DNA damage sites H2AX RNF8 ATM MDC1 PMC10909944__F9 Mechanistic schematic model of action of circRNA_SLC8A1 in macrophages against Mtb infection SQSTM1 IL6 TNF PMC6736526__F3 Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect PROX1 CA3 NEUROD1 NOTCH1 PMC11036733__F6 Dengue virus pathogenesis and host molecular machineries CGAS STAT2 C1S TRIM69 PMC4547409__F9 Model illustrating the mechanism underlying inhibition of TGFB1–induced EMT and cell migration by KF SMAD4 PMC8910364__F9 Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway COX2 MMP3 PMC12121910__F4 Integrative analysis of metabolomics and transcriptomics revealing activation of lignin biosynthesis pathway in rice infected by Pst CAD PRX HP PMC6844540__F12 PI3K-AKT signaling pathway adapted from KEGG (ID: hsa04151) (A) the predicted targets and genes were signed in red; (B) the known targets and genes were signed in red SYK MYB EIF4B BAD RAF1 EBP RBL2 PTEN CD19 MTOR ME1 EIF4E RHEB TSC2 BCR CLU PI3 MDM2 PMC6746687__F3 Schematic diagram of EB virus involved in the G1/S transition CDK6 PCNA ATM ARID3A CDK4 PMC9449326__F2 Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis MYB EGF BAD HGF EGFR EBP GSK3B PTEN MTOR MYC MAPK3 FGFR2 BCR ATF4 RBL2 CD19 VEGFA IL6 RAC1 EIF4E TSC2 ITGB1 IGF1 BRCA1 NFKB1 RELA CDK2 PMC8085147__F2 CGAS–STING signaling pathway senses cytosolic DNA derived from either viral/bacterial infection or self-DNA CGAS IRF3 IL6 TNF PMC6412864__F3 Apoptotic signaling during ER stress ATF4 EIF2A TRAF2 PMC6895604__F2 Targeting senescent cells in translational medicine BAX ATR BAD ATM PTEN HEL-S-11 MTOR RBPJ LBR PMC6412864__F2 Crosstalk between UPR and autophagy LAMP3 LAMP2 ATF4 EIF2A XBP1 PMC3001129__F2 NOD-like receptor signaling beyond the inflammasome IFNG NLRP12 NLRX1 RIGI NOD2 IRAK1 NOD1 MYD88 PMC3539662__F1 Kaposi sarcoma-associated herpesvirus K1 activates PI3K/AKT/mTOR signaling thereby activating protein synthesis and survival pathways, while inhibiting apoptotic pathways SYK GSK3B LYN MTOR PMC3565070__F3 Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections EGFR CXCL1 CXCL2 CXCL3 MPO IL1R2 HMOX1 HBEGF IL24 LPO MUC5B MUC2 DDIT3 CFTR FOXA2 CXCR4 PMC6859544__F1 Redox Regulation in Glucose Metabolism FAS HEL-S-44 PMC5393166__F1 Schematic overview of the Nrf2 pathway RBX1 KEAP1 MAF PMC5853106__F2 Non-Canonical Wnt-signaling: Non-canonical Wnt/PCP (planar cell polarity) pathway CDC42 RYK HEL-S-11 ARHA NLK PMC8655231__F2 Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease TAB3 IRAK1 ABCD4 CYLD CTNNB1 MYD88 PMC5853106__F3 Wnt Signaling Pathway in Cancer APC LRP5 LRP6 RYK CTNNB1 PMC9402571__F6 Models for the negative regulation of NFKB signaling pathways by caspase-3-mediated cleavage of NFKBs CASP9 CASP3 FADD PMC5853106__F1 The Wnt Signaling Pathway in Cancer APC LRP5 LRP6 LEF1 CTNNB1 PMC9243210__F2 Metabolic reprogramming and epigenetic modifications on the path to cancer OGA OGT KAT2A PMC5805151__F1 Interaction between stress responses and circadian metabolism in metabolic disease DBP XBP1 PMC7984428__F2 Simplified canonical model of NMD pathway activation (A) in human cells which is controlled by three different ways so far and yet to be identified (B) UPF2 SMG1 XRN1 UPF3B SMG6 PMC8273387__F4 Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes RIPK3 CASP8 MLKL BCL2 RIPK1 PMC3502514__F1 Activation of stress signalling pathways in the liver of sows during lactation CRP UGT1A1 HEL-S-128m HP GPX1 PMC8273387__F2 Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes RIPK3 TRADD MLKL OTULIN RIPK1 CYLD TRAF2 FADD PMC8374049__F2 Inflammasome Signaling: A Novel Paradigm of Hub Platform in Innate Immunity for Cancer Immunology and Immunotherapy TH GSDMD GSDMC GSDMB DFNA5 PMC11673533__F1 Artificial sweeteners affect hormonal pathways in breast cancer IGF1 INS PMC3203793__F1 Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling APC GSK3B SIRT2 PMC4679438__F3 mTOR and its tight regulation for iNKT cell development and effector function RHEB TSC2 CAD TSC1 EIF4E PMC9102229__F7 Multiomic Profiling Identified EGF Receptor Signaling as a Potential Inhibitor of Type I Interferon Response in Models of Oncolytic Therapy by Vesicular Stomatitis Virus STAT3 STAT1 EGFR IRF3 PMC5492169__F9 Schematic model describing the CD99 peptide-induced signal transduction pathway HRAS RAF1 PIN1 CD99 PMC4679438__F2 mTOR and its tight regulation for iNKT cell development and effector function RHEB TSC1 FYN CD1D PMC6722098__F1 DEGs’ products protein-protein interaction network for each mineral ADAM2 APOO POSTN COMP ELOA CYCS VCAN PMC6155514__F5 Real-time carbon allocation into biogenic volatile organic compounds (BVOCs) and respiratory carbon dioxide (CO2) traced by PTR-TOF-MS, 13CO2 laser spectroscopy and 13C-pyruvate labelling IPP LOX PDC PMC4632296__F8 A working model depicting that RILP interacts with RalGDS to inhibit Ral pathway RILP RALA PMC6628296__F1 Canonical Wnt signaling pathway illustrating therapeutic intervention points targeted by Wnt modulators PORCN DKK1 AXIN1 LRP5 LRP6 CTNNB1 PMC3203793__F6 Molecular modulation of peripheral myelination by the Sirt2/Par-3/aPKC pathway APC GSK3B SIRT2 PMC6231577__F1 Effect of radiotherapy on DNA repair, mitochondrial function, cellular ROS, and EMT H2AX PRX ATM MTOR CCNB1 SSB CCND1 PARP1 PMC5543744__F6 Proposed mechanism of hypoxic-conditioned secretome effects on liver regeneration STAT3 SOCS3 SIRT1 PMC3464683__F3 Schematic representation of a plant cell with the major components involved in symbiotic signaling and defense signaling NUP133 NUP85 REM1 PMC6865084__F3 Core genes involved in the promotion of depression in patients with ovarian cancer ZFP36 PNOC CXCL12 HEL-S-2 JUND TIMP3 EGR1 FOSB SERPING1 CHPT1 JUNB SPARC COL3A1 CCL2 FOS ATF3 PLAT KNS2 HCA112 PRELP PLOD2 PLA2G7 DCN SMARCA4 PMC6215314__F6 Illustration of heterogeneous cancer death induced by dihydroartemisinin plus epirubicin liposomes through autophagy, apoptosis and necrosis BAX UVRAG ATG14 PMC7902034__F3 Activation of the cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of IFN genes (STING) signaling pathway and AIM2/IFI16 inflammasome CGAS GSDMD STIM1 AIM2 IFI16 IRF3 SLC19A1 IL1B PMC8164981__F1 Bhlhe40 as a TRM metabolic regulator TGFBR2 NOTCH2 BHLHB2 NOTCH1 ID3 RUNX3 PMC4260746__F4 Caspase-1 activation by inflammasomes leads to pro-inflammatory cytokine production: Inflammasomes can be triggered by various stimuli NLRC4 NLRP1 HMGB1 NLRP3 TIRAP IL1B MYD88 PMC5894239__F5 Functional network overrepresented in the list of differentially expressed miRNAs in response to infection of bovine macrophages with Streptococcus agalactiae strain (a) ST103 and (b) ST12 MRAP PMC7294136__F1 Functions of extracellular S100A4 protein S100A4 TLR4 CTNNB1 PMC7902034__F1 Localization, intracellular trafficking, and signaling pathways of nucleic acid-sensing Toll-like receptors (TLRs) TBK1 UNC93B1 TLR3 TLR9 TLR8 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC3747383__F1 PPARG transduction pathway LPL CDK5 COX2 EBP PMC4671727__F1 Complement Effectors of Inflammation in Cystic Fibrosis Lung Fluid Correlate with Clinical Measures of Disease C6 HEL-S-62p C2 PMC96649__F4 Stimulation of iNOS production by Pln is dependent on the IFNG signaling pathway NOS2 STAT1 IRF1 JAK1 PMC2858523__F1 Schematic diagram showing the RAS-MAPK signal transduction pathway and affected disease genes in disorders of the neurocardiofacialcutaneous syndrome family HRAS RAF1 SPRED1 SOS1 SHOC2 BRAF CS GRB2 KRAS PMC7857397__GA Neutralizing auto-Abs to type I IFNs underlie life-threatening COVID-19 pneumonia TLR3 IFNAR2 IFNAR1 IRF7 PMC3010252__F1 Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms HRAS RAF1 SPRED1 SOS1 NF1 SHOC2 BRAF CS GRB2 KRAS PMC9470853__F7 Fatty acid export (FAX) proteins contribute to oil production in the green microalga Chlamydomonas reinhardtii FAS ABCA2 FAT1 PMC11602941__F2 TGFB family signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 NODAL PMC11602941__F3 TGFB family signaling in human pluripotent stem cells SMAD1 DKFZp781O1323 SMAD2 SOX2 SMAD4 NODAL PMC7882887__F4 Emerging role of estrogen related receptorA in complications of non-small cell lung cancers TSC2 TSC1 MTOR PMC5003543__F4 Working model of consequences of PREX2 truncating mutations CDKN1C PTEN PREX2 IGF2 RAC1 PMC7196371__F9 Functions of HT in AD STAT3 KEAP1 PMC7324377__F1 Biological pathways associated with the response to Ni(S-tcitr)2 in yeast APOE PMC4654310__F6 Schematic model of SOCS-1 induction in a TLR4/MyD88-dependent and IFN-Beta-dependent signaling pathway STAT1 TLR4 JAK1 MYD88 PMC7809757__F1 EDA signaling pathway EDARADD TRAF6 EDAR PMC9453694__F1 Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non–small cell lung cancer EGFR GSK3B PTEN PMC7902134__F3 Yixin-Shu Capsules Ameliorated Ischemia-Induced Heart Failure by Restoring Trx2 and Inhibiting JNK/p38 Activation PPARG DGIC SMAD4 MYD88 TSC2 GNA11 RET CP MYLK2 TF BMP10 LDB3 TRH HEL-S-273 ENO2 MSLN HEL-S-62p ADRA1A INA LOXL1 IFIH1 SIX2 PTEN COL10A1 NEFL RPLP2 ENPP1 IKBKG CASR TPM1 ACTA2 HADHB MYL1 COL1A1 MYL3 NOS1AP tmp_locus_29 MYH7 HEL-S-14 TTN CNR1 TNNI3 DMD ROMO1 OAS2 CACNA1S FGF23 JUP CAV3 ANKRD23 CD2 COL1A2 GDNF P4HA3 FKBP1B COL9A1 SP7 GLA CD19 PNPLA2 NR1C1 PMC8480058__F2 Macrophages and cancer stem cells: a malevolent alliance CD44 CD80 SOX2 EPHA4 SRC BTN3A3 CD47 PMC8041205__F8 TcpC inhibits toll-like receptor signaling pathway by serving as an E3 ubiquitin ligase that promotes degradation of myeloid differentiation factor 88 TRAF6 UBE2D1 MYD88 PMC10474437__F2 Differentially expressed non-coding RNAs and their regulatory networks in liver cancer FOXA1 STAT3 EGF SMAD1 HGF TGFA DKFZp781O1323 SMAD2 APC PTEN CTNNB1 ANXA11 DKK3 CDK6 GRB2 SRC CDK4 PMC7530268__F1 Ferroptotic cascade FTH1 CISD1 LOX FTL KEAP1 GPX4 FACL4 SLC7A11 HEL-S-64p PMC7689683__F1 Signaling pathways of three estrogen receptors HBEGF EGFR GRB2 SRC PMC6280671__F4 Integrated Analysis Reveals Genomic and Expression Alterations in Signaling Pathways in HNSCC Differing in HPV Status PIK3CA ATR TNFRSF10B EGFR PIK3R2 AKT3 GSK3B SFN PTEN MTOR PLK1 CTNNB1 RB1 FGFR1 ATM MDM2 BIRC3 CASP8 EIF4E GSK3A CDKN1A TNKS FOXO1 GYS1 PPP2R1B CASP3 CHEK1 DVL3 PARP3 RFC3 BIRC2 NFKBIB FADD PMC11058355__F2 Functions of Mincle SAP130 SYK BCL10 CARD9 PMC9601310__F7 Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis MUSK LRP4 PMC2686112__F1 VHL gene complex targets hypoxia-inducible factors (HIF) for ubiquitin-mediated degradation TGFA F2 EGFR VHL PMC5953846__F8 Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer BAX NPS ABCC1 ABCG2 ABCB1 FADD PMC3336107__F1 The Unfolded Protein Response in the ER ATF4 XBP1 PMC3154715__F3 Working model of relaxin sustained-vasodilatory response PMC8268128__F2 Adipose Tissue-Derived Extracellular Vesicles and the Tumor Microenvironment: Revisiting the Hallmarks of Cancer STAT3 SOX9 MMP3 ATM TERT CCL2 TNF CTNNB1 VHL PMC5097071__F6 Redox homeostasis and metabolic changes during the adaptation to proteasome inhibitors ACLY ACSF2 ACSF3 HEL-S-133P PMC4664160__F4 Druggable Sensors of the Unfolded Protein Response BAX NLRP3 TXNIP MCL1 BCL2 ATF4 EIF2A PMC2696125__F2 Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease BAX BAD COX2 BIK PMC7058937__F2 Cell junction formation and maturation under RhoGTPase control in epithelial cells CDC42 ARF6 NUMB ARHA RHO RAC1 PMC11959089__F1 Overview Diagram of Ferroptosis Mechanism in Mycobacterium tuberculosis, EB Virus, and SARS-CoV-2 Infections GPX4 PTPA SLC7A11 PTGS2 PMC6482429__F1 Molecular pathways targeted by the TCMs covered in this review are summarized RIPK3 SIRT3 HMGB1 FAS MLKL TLR4 RIPK1 MTOR TNF TRAF2 SIRT1 MYD88 PMC7404778__F2 Graphical representation of the mechanism of action of bioactive compounds on the antioxidant and immune response KEAP1 MAF TNF MPO PMC9319825__F1 Emerging Biomarker-Guided Therapies in Prostate Cancer PTEN MTOR PMC3051174__F3 TLR4 signaling – a converged immune response pathway for hemorrhagic shock and septic shock TLR4 IRF3 MYD88 PMC10975235__F2 Type I IFN signaling STAT3 STAT1 STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IRF7 MTOR JAK1 TYK2 PMC5572260__F4 Signaling in human glioblastoma cell lines after treatment with vascular endothelial growth factor (VEGF), irradiation and axitinib CDC42 MAPKAPK2 PEG3 PMC5569752__F1 ER stress-mediated apoptosis and inflammation in cardiovascular disease BAX NLRP3 TXNIP ATF4 EIF2A PMC5569752__F2 Chronic effect of exercise on the ER stress-associated apoptosis and inflammation BAX NLRP3 TXNIP IL1B PMC5059456__F9 Regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways STAT3 APC GSK3B TCF4 CTNNB1 PMC8999618__F2 Sequence Requirements for miR-424-5p Regulating and Function in Cancers ATR BRCA1 WEE1 ATG14 CDK2 ATM MYT1 VEGFA MYC CDK4 PMC8999618__F3 Sequence Requirements for miR-424-5p Regulating and Function in Cancers STAT3 APC MAL FACL4 SMAD4 MTOR AMER1 MIEF2 KIF23 CTNNB1 UCP2 SIRT3 PRC1 CASP3 BCL2 APAF1 CCND1 PMC7535921__F8 Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation HDAC3 FANCD2 PMC2984500__F2 Selection of miRNA implicated in the TLR4 signalling pathway SOCS1 TIRAP TLR4 MAL IRAK1 TRAF6 IRAK4 MYD88 PMC9700348__F1 Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via A6B1 Integrin-Fyn-RhoA-ROCK Signaling FYN RHO RAC1 PMC6274979__F1 The activation of Yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) in epithelial cells and fibroblasts BIRC5 BCL2L1 AXL AREG CCND1 PMC2694443__F8 BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway SOST LRP5 LRP6 PMC8034969__F8 JAK-STAT signaling pathway and other related signaling pathway as well as the mechanism of the function of inhibitors identified in this study EGF MTOR PMC8007386__F6 Model depicting the role for microvillous cells involvement in the olfactory epithelium innate immune response to viral infection IL25 GNAT3 ALOX5 TRIM25 PLCG2 TRPM5 IL17RB PTGS1 PMC5837624__F1 Proposed mechanisms of cell injury induced by APOL1 variants NLRP12 NLRP3 TLR4 APOL1 IL1B PMC6862063__F12 Schematic summary of IL-6 induced effects on the JAK-STAT pathway and its main regulator, SOCS SOCS1 STAT3 SOCS3 IL6 JAK1 IL6R PMC3179880__F2 Functional role of skeletal muscle-derived neurotrophic factors after exercise RHEB GDNF MTOR BDNF RET PMC9382818__F1 Improved energy efficiency in microbial fuel cells by bioethanol and electricity co-generation PDC HEL-S-32 MB MDH2 HEL-S-26 PMC8532137__F1 Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology NR1i1 CYP2R1 CYP27A1 CSF1R IL1B PMC3931066__F7 Activation of the ATR-signaling pathway during G1/G0 or G2-M phases of the cell cycle XPA TOPBP1 ATR ATRIP PCNA XPC PMC8579187__F4 Interactions between the renin–angiotensin, complement and kallikrein–kinin systems on the vascular wall MASP1 C6 C7 MASP2 C1S C9 ACE2 PMC9221635__F2 Telomere Maintenance and the cGAS-STING Pathway in Cancer RAD51 DKC1 NHP2 GAR1 NOP10 ATM TERT SIRT1 PMC9221635__F3 Telomere Maintenance and the cGAS-STING Pathway in Cancer TBK1 CGAS IRF3 PMC11761133__F5 Functional model of resilience ATP8B1 KLF4 KIF26B PVALB GFAP NTRK2 LINGO1 RBFOX1 ANGPT2 BDNF RELN SST PMC7403229__F7 Mechanisms by which melatonin ameliorates oxidative stress via modulation of the Nrf2 pathway in cryopreserved OTs BAX GSTM1 PMC8579187__F1 Renin–angiotensin system PRCP ACE2 PMC11276752__F1 Deciphering Drug Resistance: Investigating the Emerging Role of Hyaluronan Metabolism and Signaling and Tumor Extracellular Matrix in Cancer Chemotherapy CD44 UGDH UXS1 HAS1 HAS3 HAS2 RHO PMC6585057__F7 Summary and schematic diagram of this study STAT1 OASL IFI27 MX1 IRF7 CCL5 HLA-B CXCL10 HLA-C HLA-A PMC11677181__F1 Wnt signaling pathways and the targets of their inhibitors JUN ROCK2 PORCN TNKS APC ARHA DAAM1 CTNNB1 PMC2662567__F2 Genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders RHEB CD44 HGF NF1 PLAUR PLG MTOR PMC6162743__F7 Prx II regulates CSC properties of colorectal cancers via PI3K/AKT, Hedgehog and Wnt/Beta-Catenin signaling APC GSK3B PRX SMO CTNNB1 PMC2662567__F3 Genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders RHEB NF1 PLAUR PTEN MTOR PMC11864756__SF1_3. Analyses of differentially expressed genes that were enriched at different timepoints DUSP5 DUSP10 MAFK APP TNF FOS PMC7497778__F2 Functions of HSCARG in the cytoplasm ASL TRADD IRF3 TRAF3 TNF TRAF2 PMC3339861__F3 EGF decreases sphingolipid biosynthesis transcripts EGF UGCG ACER1 FA2H SGPL1 SPTLC3 SPHK1 DEGS1 SGMS2 DEGS2 KDSR SGPP2 PMC3339861__F4 EGF decreases free fatty acid (FFA) biosynthesis transcripts EGF FASN OLAH HSD17B12 PMC4559887__F1 Homocysteine metabolism and major factors associated with hyperhomocysteinemia in rheumatoid arthritis patients VIT PMC6162743__F2 Overexpressed Prx II regulates stemness-associated properties of HCC cells EPCAM FOXM1 SOX2 PRX CCND1 PMC9313346__F2 P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells PANX1 CD80 APC MTOR PMC5546018__F1 NDRG1 inhibits oncogenic signaling pathways by down-regulating the ErbB family of receptors STAT3 EGF TGFA PAK1 EGFR RAC1 PMC5512074__F6 Schematic overview of p90RSK-mediated regulation of UBR5-containing miRISC TBK1 UBR5 TRAF3 PMC9125963__F2 Mechanisms involved in controlling RNA virus-induced intestinal inflammation TBK1 MAVS AKT3 IRAK1 IRF3 IRF7 TRAF3 MYD88 DDX1 NLRP6 TLR3 DHX36 DHX15 TLR7 PMC9125963__F3 Mechanisms involved in controlling RNA virus-induced intestinal inflammation TBK1 MAVS NLRP6 DHX15 IRF3 IRF7 PMC12143691__F1 Gut microbiota interacts with the mammalian epigenome by generating epigenetic substrates or acting as regulators for chromatin-modifying enzymes ALKBH5 WTAP METTL14 METTL3 KAT2A PMC9125963__F4 Mechanisms involved in controlling RNA virus-induced intestinal inflammation GSDMD NLRP6 NLRP3 DHX15 PMC12143691__F2 Epigenetic modifications induced by gut microbiota promote inflammatory bowel disease (IBD) HDAC3 HDAC1 ATG16L1 NLRP3 HDAC5 METTL14 AHR CEACAM6 FOXP3 ATG5 PMC6002427__F3 Signaling pathways in mast cell biology SYK LAT KIT LYN GRB2 SRC PMC2235195__F1 RA synthesis pathway CYP26B1 CYP26C1 RARA RARB RXRA RXRB CYP26A1 PMC3236823__F2 Evolution of the mTOR pathway RHEB HERC1 TSC2 RICTOR MAP4K3 TSC1 SGK1 INSR GSK3B PTEN MTOR TNF PMC6903684__F1 Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria FH ACO2 CS MDH2 PMC8706107__F1 HPV16 Entry into Epithelial Cells: Running a Gauntlet IFNG CGAS MYPOP SP100 PML PMC7316955__F3 Representative pathways of differentially expressed genes MAK LEPR ddo APP IL6 MTOR INS PMC4924657__F8 Double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression IL4 ARG1 IRF4 JAK1 PMC4369817__F6 Schematic diagram of the mechanism whereby miR-16 attenuation contributes to myocardial hypertrophy STAT3 CCNE1 CCND1 CDK4 PMC8819183__F3 Comparison of Tendon Development Versus Tendon Healing and Regeneration GDF5 gdf7 EGR1 SMAD2 EGR2 SCX MKX GDF6 PMC5412355__F3 The UPR downstream signaling pathway ELF2 XBP1 PMC10910709__F9 Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis GSDMD NLRP3 KEAP1 PMC8056081__F2 Diagrams of a hypothesized extreme resistance pathway and its possible relationship to the hypersensitive response TF AGO4 NRG1 SAG PMC8056081__F1 Extreme resistance to viruses in potato and soybean hosts TF AGO4 NRG1 SAG PMC8960923__F1 Estrogen Receptor Complex to Trigger or Delay Estrogen-Induced Apoptosis in Long-Term Estrogen Deprived Breast Cancer ERG MTOR PMC9592792__F3 Population‐based meta‐analysis and gene‐set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids TG ABCG8 ABCG5 GUGU APOB PMC9312706__F2 Drug Repurposing: The Mechanisms and Signaling Pathways of Anti-Cancer Effects of Anesthetics BAX GSK3B SLC7A11 PMC8960923__F2 Estrogen Receptor Complex to Trigger or Delay Estrogen-Induced Apoptosis in Long-Term Estrogen Deprived Breast Cancer STAT3 ATF4 EIF2A TNF PMC9312706__F3 Drug Repurposing: The Mechanisms and Signaling Pathways of Anti-Cancer Effects of Anesthetics CDC2 PTEN MTOR PMC9605520__F3 Preclinical and Clinical Research Models of Prostate Cancer: A Brief Overview HSD3B2 HSD17B3 CYP17A1 CYP11A1 HSD17B1 HSD17B2 RDH5 AKR1C2 PMC1052008__F1 Activation of PI3K/Akt signaling in adaptive versus maladaptive hypertrophy PTEN MTOR PMC5871897__F2 RAS-ERK signaling pathway EGF EGFR GRB2 PMC1052008__F3 GSK-3 as a convergence point in hypertrophic signaling HEL-S-28 NFATC3 GATA4 CTNNB1 PMC2795439__F1 Androgen-receptor signalling in normal prostate and PCa STAT3 EGFR PMC6539482__F1 The core components of the mammalian Hippo signalling pathway LATS1 LATS2 PMC5871897__F5 Colorectal tumorigenesis by both APC and KRAS mutations APC GSK3B KRAS CTNNB1 PMC5871897__F3 Aberrancies of the Wnt/Beta-catenin and RAS-ERK pathways and their cooperation in the tumorigenesis EGFR APC GSK3B LRP5 LRP6 GRB2 CTNNB1 PMC5871897__F4 Wnt/Beta-catenin and RAS-ERK pathway crosstalk EGF EGFR APC GSK3B LRP5 LRP6 GRB2 CTNNB1 PMC7689184__F16 TNFSF15 regulation of antimicrobial pathways NOS2 TNLG1B ATG16L1 TRADD IL16 NOD2 ATG5 TRAF2 FADD PMC5884684__F1 Connections between circadian cycles, C/EBPs and the NAD+-Sirt1 pathway may affect G-CSF induced granulopoiesis CEBPA SIRT1 PMC5871897__F8 KYA1797K as a potential strategy to overcome resistance to EGFR targeting drugs in CRC TNKS EGFR APC GSK3B LRP5 LRP6 GIP GRB2 CTNNB1 PMC9046588__F2 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy CD36 GC IRF1 ARG1 MYC BCL6 BCO1 PMC9046588__F3 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy PRMT1 JMJD6 TRAF6 MYD88 PMC7762355__F1 Inflammatory regulation mechanism in a TREM1/2-TLR4-dependent manner in the liver TREM2 SYK TREM1 TLR4 CD14 IRAK1 SRC TRAF6 IRAK4 CARD9 MYD88 PMC9046588__F4 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy PRMT7 PRMT2 MAVS PRMT3 IRF3 IRF7 TRAF6 PMC9046588__F5 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy PRMT1 TBK1 CGAS PRMT6 IFI16 IRF3 IRF7 PMC9046588__F6 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy RAF1 SOS1 PRMT6 APC GSK3B PTEN HIF1A ATF4 GRB2 MYC CTNNB1 PMC6904751__F7 TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKB/VPS34 pathway ULK1 WIPI2 TFEB PMC5705392__F2 Immunobiology of the IL-15-IL-15RA Complex as an Antitumor and Antiviral Agent STAT3 JAK3 JAK1 PMC4336604__F9 How p-CREB acts as a common downstream effector for multiple signaling pathways that regulate BCRP mRNA expression Xie, et.al EGF EGFR CRTC2 PMC4019937__F2 Phylogenomic reconstruction of archaeal fatty acid metabolism HEL-S-5 CR2 ACD PMC7914341__F8 PRLR-SF inhibits pentose phosphate pathway through NEK9-YAP/TEAD1-G6PD/TKT axis in PDAC cells HEL107 NEK9 PMC4209186__F9 Diabetes Recovery By Age-Dependent Conversion of Pancreatic D-Cells Into Insulin Producers FOXO1 MYC SKP2 ID1 PMC2288663__F6 Nucleotide excision repair pathway TF ERCC1 XPA PCNA CPD XPC PMC7352365__F3 The p53/MDM2 pathway by HERC2 HERC2 ATR ATM MDM2 NEURL4 PMC10539948__F1 IFNG signalling pathway SOCS1 EHBP1L1 STAT1 SOCS3 MTOR JAK1 PMC6859819__F3 TRK signalling pathway NGF C2 GRB2 PMC6539482__F3 Interaction between TNFA and the Hippo signalling pathway LATS1 BAX MOAP1 TRADD TRAF2 PMC9640836__F4 PAX5 alterations in B-cell acute lymphoblastic leukemia CDKN2A ZCCHC7 ETV6 PAX5 PMC12183287__F2 BAs contribute to host metabolism in various organs through FXR and TGR5 FGF8A PYY ABCG5 CCL21 NPC1L1 CYP7A1 FASN FGFR4 UCP1 CYP27A1 PMC5806628__F5 Summarization of biological function by a Concept Ontology WAS UNG PTEN PMC5861661__F1 p53-dependent cell death pathway BAX ATM MDM2 PMC6753234__F8 Microbiome–gut–brain axis in relation to AD PC PAH LPCAT1 PMC6162467__F4 CCN2 in regulation of LRP5/6 dependent Wnt signaling CTGF CTNNB1 PMC4162195__F6 Working model HES1 NOTCH1 HES5 PMC7572679__F2 Metformin modulates lipid metabolism in the intestine, liver, and adipose tissue TG FAS GSK3B MFF CTNNB1 PMC11791038__F7 FAM210B inhibits the proliferation and metastasis of lung adenocarcinoma via interacting with TOM70 and promoting IFNA/B production FAM210B STAT1 MAVS IRF9 IFIT3 IRF3 PMC2735864__F1 Genetic Variation in TNF and the NFKB Canonical Pathway and Risk of Non-Hodgkin Lymphoma TRADD TRAF5 RIPK1 TRAF2 PMC3295195__F10 A novel mechanism linking ROS/Src/caveolin-mediated activation of the EGFR-ERK signaling pathway to chronic Ang II exposure-induced EMT in cultured renal tubular epithelial cells HBEGF EGFR PMC9036252__F1 Two Modulators of Skeletal Development: BMPs and Proteoglycans BMPR2 ACVR2B SMAD1 ACVR2A MAP3K7IP1 DKFZp781O1323 RUNX2 PMC10950852__F9 Paradigm illustrates the beneficial efficacy of ginseng extracts in modulating circadian rhythm and inflammation FFAR3 PGLYRP1 PCNA TLR4 FGF21 NOD2 PMC8445516__F2 Robinow syndrome-associated genes involved in the WNT/PCP pathway identified in human subjects FZD2 NXN ROR2 PMC3722318__F1 Autophagy master regulator TFEB induces clearance of toxic SERPINA1/Alpha-1-antitrypsin polymers NFKBIA SERPINA1 TFEB IL6 PMC7156751__F7 A simplified tumor environment model STAT3 STAT1 STAT2 TLR4 CXCL1 IL18 IRF7 SOCS3 IL6 CXCL10 IL1B PMC9496462__F1 Dynamic Regulation of NFKB Response in Innate Immunity: The Case of the IMD Pathway in Drosophila HDAC1 CYLD FADD PMC4524510__F2 Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy FAS TRADD FADD PMC2699281__F2 Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease BAX MDM4 MDM2 PMC2699281__F3 Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease HEL-S-62p VCAM1 PMC5281639__F1 Induction of interferons (IFNs) and establishment of an antiviral state in a model chicken cell CSA2 TBK1 STAT1 JUN MAVS TLR3 STAT2 IRF7 ATF2 TYK2 PMC7347488__F1 Renin angiotensin system enzymatic cascade depicting primary receptor systems, biological actions of Angiotensin 2 and Ang-(1–7) and balance between ACE and ACE2 ACE2 PMC6676786__F2 TGFB family members exhibit distinct effects on heart hypertrophy TGFB binds to its own receptors RII and RI, activates TAK1, SMAD2/3, and p38, and moderately promotes cardiac hypertrophy IGF1 SMAD2 GDF15 TGFBR3 GFRAL PMC6676786__F3 The TGFB superfamily in cardiac dysfunction POSTN SMAD2 SMAD4 RHO TCF21 NOX4 TGFBR1 PMC4141540__F7 Schematic model of WNT7B signaling in CRPC cells and osteoblasts MARCKS WNT7B PMC7597673__F9 Photoreceptor metabolism cycles between an anaerobic light cycle and an aerobic dark cycle associated with phototransduction through PDE6 activities and mediated by SIRT6 and HIFlA HIF1A MTOR SIRT6 PMC12006985__F3 An overview of TAG synthesis pathway LPA GPD1 PMC7585830__F3 Positive and negative regulation of Hp (HAMP) transcription and systemic iron homeostasis through the Hp/Fpn signaling pathway POR ERFE STAT3 BMP6 HPR SMAD4 EPO HP HFE2 PMC7585830__F4 Altered iron homeostasis in breast Cancer Cells and the contribution of their microenvironment IFNG STAT3 S1PR1 SIRT3 SMAD4 IL6 HP SIRT2 IL6R HFE2 PMC7585830__F5 Summary for Inhibitors of the upstream hepcidin signaling: IL-6/IL6R/JAK/STAT3 and BMP/SMAD pathway STAT3 BMP6 SMAD4 HAMP HFE2 PMC2857022__F7 Mechanistic model of KLF11-mediated tumor suppression and its antagonism by an oncogenic pathway TIEG2 SIN3A EGFR PMC6581210__F1 Mitochondrial pathways of apoptosis and venetoclax mechanism of action BAX BAD BIK PMC2674698__F1 Structures and metabolic pathway of gangliosides () GM2A HEXA PMC8875868__F5 Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance BAG3 PAK4 ATM PTEN PMC8875868__F6 Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance HPD HDAC10 MGAT3 PMC8419469__F5 Analysis of Gene Expression Data Incorporating Tumor Purity Information LAMC2 COL27A1 LAMB3 LAMB2 COL5A3 LAMA4 SRC COL5A2 LAMA3 PMC8875868__F7 Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance HEL-S-22 PRMT6 NDP PMC2752847__F1 Type I interferon production by dendritic cells in host defense TLR1 MAVS PDC IRF3 TLR7 IRAK4 PMC9434059__F1 Specific epigenetic regulators serve as potential therapeutic targets in idiopathic pulmonary fibrosis STAT3 ACTA2 COL1A1 COL1A2 SMURF1 SMAD2 CTGF PMC8632454__F2 Recent and Upcoming Drug Therapies for Pediatric Heart Failure PLN TNC GC PMC3047627__F3 RECK pathway in stromal–epithelial interaction in prostate cancer HRAS MMP14 TIMP3 TIMP1 RECK TIMP4 MMP2 MMP3 MMP9 PMC6755252__F5 Signaling pathway regulation network of the three validated differentially expressed tRFs APPL1 PIK3CD SMAD2 GSK3B SKP2 TRAF6 PDPK1 FGFR1 CHP1 MDM2 SRC LRP6 IRS1 ADCY3 COL27A1 GRB2 GNAI3 GNAO1 HEL-S-273 TGFA CHRM1 EGFR CHD8 CTNND1 PRKAG2 NRG3 ATP2A2 IGF1R HTR2A LAMC1 MYLK3 MYLK4 RPS6KA6 TGFBR2 HTR6 EEF2K CREB3L2 BTRC MAP2K4 CCND2 GUCY1A2 ARHGEF12 FGF9 TPM3 ATP1B4 TACR1 SENP2 DKK2 PPM1B SHC3 LPAR3 NKD1 HRH1 PDGFD GPC1 PHKG2 SCN7A E2F2 SOCS4 KCNJ6 FZD7 BST1 GNAL FGF2 CBL DVL3 MAP2K1 PMC10879340__F4 Zebrafish Studies on TGFB Signaling and Pharyngeal Arch Patterning BARX1 GREM2 PRRX1 HAND2 GATA3 PMC8215710__F1 RIPK1-Associated Inborn Errors of Innate Immunity TRADD NLRP3 TAB3 RIPK1 TNF TRAF2 FADD PMC8739918__F4 Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis IFNG DHRS7B TYSND1 TLR4 CXCL10 LBP PMC9047021__F1 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer RAN DGCR8 DROSHA PMC3849893__F1 Interferon signaling pathway STAT2 IRF9 JAK1 TYK2 PMC9047021__F2 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer ULK1 TLR4 MYD88 PMC3800064__F2 The canonical and noncanonical NFKB pathway RELA RELB TRAF3 PMC1280267__F7 Model schema for the phosphorylation of CRMP-2 by Rho kinase, Cdk5, and GSK-3B CDK5 SEMA3A FYN GSK3B NUMB RHO PMC9247520__F2 Cryptic Phosphorylation-Mediated Divergent Biosynthesis of High-Carbon Sugar Nucleoside Antifungals MALL POLK POLI PMC9047021__F3 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer ATG16L1 SENP1 ATG5 PMC9047021__F4 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer RHEB DGCR8 PHF5A MTOR KAT2A PMC8005608__F3 TRIM-mediated regulation of innate immune signaling pathways TRIM13 TRIM14 TBK1 TRIM38 CGAS TRIM32 TRIM56 MAVS TAB3 TANK TLR9 TRAF3 TRAF6 TRIM21 MYD88 NLRP3 IL16 TLR4 NOD2 TLR8 TLR7 ECSIT TRIM31 IRF3 TRIM25 TLR3 DDX41 TRIM8 TRIM6 TRIM4 TRIM29 TRIM65 TRIM23 PMC7999520__F8 The signaling pathway by which the neogenin ligand RGMc enhances follicular development OXTR COX1 EDN2 COX2 TBXA2R ADRA1D PMC2963106__F2 VHL in clear-cell renal cell carcinoma and its relation to targeted therapy EGFR MAPKAPK2 MAPKAPK3 EPO BNIP3 MTOR PMC4169143__F1 Back to the Future: Oral targeted therapy for RA and other autoimmune diseases RHEB MLST8 TSC2 TSC1 GRB2 MTOR JAK1 SHE PMC6883692__F5 Tobacco-smoking associated genes map to interconnected interferon and stress response signaling networks KLF4 SERPING1 IFIT3 AIM2 TAP1 IFI35 SASH1 STAT1 SP100 IFNAR1 OAS1 APAF1 OAS2 PMC10151830__F7 Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy tmp_locus_29 HEL-S-162eP FASN ACACA ACADM PMC6549073__F9 Cisplatin-induced apoptosis in p53-intact and p53-disrupted signaling pathway conditions CDC2 ATR WEE1 PMC4625378__F2 Ceramide is the hub of sphingolipid metabolism CERS3 CERS5 SMS CERS1 tmp_locus_29 CERS2 CERS6 PMC5649420__F2 Integration of Canonical and Noncanonical Pathways in TLR4 Signaling: Complex Regulation of the Wound Repair Program BAMBI FYN TLR4 EGFR SMAD4 PTEN LYN ARHA TRAF6 MYD88 PMC4423712__F1 Cardiolipin synthesis and remodeling pathway PGS1 PGP CDS1 PC PMC6497892__F2 Comprehensive overview of the role of Clusterin on apoptosis-related events in cancer cells IGF1 ATM PMC4637098__F2 Kelch-like chicken erythroid-derived cap “n” collar homology factor-associated protein 1- (Keap1-) NF-E2-related factor 2- (Nrf2) antioxidant response element (ARE) signaling pathway RBX1 JUN KEAP1 NQO1 MAF PMC7311391__F6 Overall regulatory networks of miRNAs, circRNAs and mRNAs BAX CASP3 BCL2 PMC9450187__F1 Molecular Mechanisms of New Bone Formation in Axial Spondyloarthritis TPH1 HTR1B LRP5 LRP6 CTNNB1 PMC6829950__F7 Summary of SP600125 enhances C-2-induced cell death in bladder cancer cells through resisting JNK- SQSTM1/p62- Nrf2 mediated anti-apoptotic pathway and switching autophagy to apoptosis ATG3 KEAP1 ATG5 PMC10853543__F4 SOX TFs acts as the hub of signaling pathways in the tumorigenesis HGF GLS SMAD2 GSK3B NUMB CD133 IL6R FGF8A ALK NLRP3 SOX9 ETV6 FLT4 FOXQ1 SOX1 FGFR4 CCL7 SOX18 BMF IGF2BP2 SOX7 SOX4 CCR1 CDH2 FGFBP1 JUP MMP7 MCAM GOT2 SOX13 FRS2 SOX11 SOX12 SOX30 SOX2 DSC3 EZH2 IGF1 ASNS TWIST1 PMC8703482__F2 B Cell Involvement in the Pathogenesis of Ankylosing Spondylitis CD74 B2M SIRT1 PMC7923882__F13 Mechanisms for poly(dA:dT)-mediated HSV-2 inhibition in human cervical epithelial cells STAT3 STAT2 IRF3 IRF7 IL10RA GBP5 STAT1 RIGI IFNAR2 IFNAR1 ISG15 OAS1 TYK2 OAS2 PMC5576060__F1 Insulin and the PI3K/AKT Signaling Pathway Regulate Ribonuclease 7 Expression in the Human Urinary Tract IRS4 MTOR IRS1 PMC8675856__F7 Long non‐coding RNAs and their targets as potential biomarkers in breast cancer TAF5L CYP4F3 CYP4F8 PMC8675856__F8 Long non‐coding RNAs and their targets as potential biomarkers in breast cancer TAF5L CYP4F3 CYP4F8 PMC4865098__F7 Circadian rhythm pathway regulated by CTV-B2, CTV-B6 and CaLas-B232 PRR9 PRR7 ELF3 CAT56 PMC5642448__F1 Insulin signalling pathway PTEN GRB2 SHE PMC7783402__F2 Role of IIS signaling pathway in reproduction and its longevity Schematic diagram elicits that IIS is actively involved in reproductive function and lifespan in C PDPK1 PTEN GRB2 PMC5378188__F2 Animal NLRs provide structural insights into plant NLR function NLRC4 NAIP NLRP3 NOD1 PMC7775142__F5 Synthetic gene circuits for self-regulated drug delivery systems CD2 ADAMTS5 IL6 CXCL10 CCL2 PMC10867181__F3 Hypoxia regulates the metastatic cascade TCF3 ANGPTL4 LOX PAFAH1B1 HEL-S-28 HIF1A CXCR4 CTNNB1 PMC8430835__F1 Emerging Role of Non-coding RNAs in Drug Resistance of Ovarian Cancer PMC3899918__F2 Jak-STAT Signaling Pathway from KEGG (ID: hsa04630) overlaid with log2 fold change values using PathVisio indicating up (red) or downregulation (blue) following ART CBL EPO PMC6852473__F5 Comparison of central metabolic features of the Rifle comammox Nitrospira NONO PMC8406911__F8 CIRP promotes the progression of non-small cell lung cancer through activation of Wnt/Beta-catenin signaling via CTNNB1 CD44 MMP7 PTBP1 VEGFA EIF2A CCND1 LEF1 CTNNB1 EIF4E PMC3760419__F4 Cell Death in Disease: Mechanisms and Emerging Therapeutic Concepts BAX FAS TNF FADD PMC4181300__F2 Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes IL15 HEL-S-103 VEGFC TNFRSF1B HSPG2 TSHR F5 TNFRSF1A DHFR F7 IL2RA SCNN1A CCL2 IL6R IL1R2 IFNG IL1R1 PLAT STAT5B BCR NOD2 PTGS1 IL18 MMP2 MMP3 TLR7 TIMP3 IL10 SELE MMP10 CTLA4 IL10RA MMP9 VEGFA IL6 NR3C1 MTHFD1 IGF1 IL1RN PON1 ADRB2 HEL110 THBS4 PGRMC1 THPO IL12B NFKBIB IL10RB PMC7376555__F4 Schematic model illustrating cellobiose-elicited action of ER stress and lignocellulase synthesis SEC63 CDT1 SEC61G CWH43 SEC62 PMC4833515__F3 Oxysterol-Related-Binding-Protein Related Protein-2 (ORP2) Regulates Cortisol Biosynthesis and Cholesterol Homeostasis CORT HSD3B2 CYP11B2 CYP11A1 PMC4181300__F3 Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes VWF NOS2 TNFRSF1B FAS CSF1 MMP10 CD14 IGF1R IL1A TNF VCAN LIPC IFNG FGF7A REN PLAT IGF1 F3 PMC9324263__F7 Disruption of O-GlcNAcylation Homeostasis Induced Ovarian Granulosa Cell Injury in Bovine CDC42 OGA BAX PCNA TXNIP PMC10647353__F4 Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis MAML3 MAML2 PMC4772349__F2 Candidate driving genetic alterations and their druggability in AYA cancers PTEN MTOR CTNNB1 DDB1 CDK6 ALK CDKN2C RASA2 NF1 MSX1 POLG AXIN1 FAT1 MDM2 POLE CDK4 PMC5660709__F5 Mycobacterium tuberculosis interferes with phagosome maturation STAT3 CD36 UVRAG PTPA VPS33B EEA1 PMC3144426__F1 Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) ATF4 EIF2A XBP1 PMC10647353__F2 Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis SOX9 PORCN APC SOX2 SPIN1 HIPK1 CTNNB1 PMC4633016__F3 Schematic diagram showing the convergence of WNT and NOTCH signaling onto cell cycle regulation EGFR FZD1 CCND1 LEF1 RBPJ NOTCH1 CTNNB1 PMC10647353__F6 Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis SMAD2 SMAD4 ATM PMC4528692__F4 ΔNp63 and TAp63 TF networks TP73 SMAD2 MYC APP NOTCH3 CEBPB NOTCH1 DLX3 BNC1 CITED4 TFCP2L1 IKZF1 BACH2 LYL1 TCL1A E2F2 SOX15 LZTS1 SOX2 JAZF1 TFAP2A IRX1 NFATC1 VAV1 TCF7L1 IRF8 BCL11A NFYB SNAI3 RUNX3 IRX4 KLF15 ELL3 TANC2 RUNX1 MAFF TFEB EP300 LEF1 GLI3 PMC11534180__F11 Alzheimer's disease pathway modified from the KEGG database [29] ULK1 ACD MTOR INS COX2 INSR APP ATF4 LPL IDE CASP9 CASP12 APC ELF2 SNCA TNF TUBB ATG101 CDK5 RTN3 RTN4 ABO CASP3 NRBF2 MCU TRAF2 FADD PMC11534180__F13 PPI subnetwork of DEGs from HC and EC tissue RPL8 RPL13A HEL-S-162eP RPL4 SNAP25 RPS9 TUBB SYT1 PS1TP5BP1 PMC7492390__F2 Immunological basis of TCMR CXCL9 IFNG CXCR3 APC CXCL10 PMC3257753__F1 TWEAK-Fn14 signaling system TRAF5 TRAF6 TRAF2 PMC7492390__F3 Complement-dependent mechanisms of antibody mediated rejection VWF CD59 HEL-S-62p PMC5732752__F8 Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle FRS2 HEL-S-162eP GSK3B PMC3815941__F3 Bacterial and host effector molecules with potential probiotic effects LTA TLR9 PMC11739150__F1 Structures of the insulin/insulin-like growth factor (IGF) system TSC2 BAD IGF1 GRB2 SHE IGF2 PMC5732388__F3 Key downstream genes were identified in the PLK1 signaling pathway PSMD12 RGCC BUB1B NCAPG NEK2 KIF20A ZWINT MYC PMC8773933__F2 Bcl-2 Family Proteins in Estrogen Receptor-Positive Breast Cancer and Their Implications in Endocrine Therapy TF SP1 SRC PMC8773933__F3 Bcl-2 Family Proteins in Estrogen Receptor-Positive Breast Cancer and Their Implications in Endocrine Therapy BAX BAD APAF1 BIK PMC6102046__F6 CNPY2 is a Key Initiator of the PERK-CHOP Pathway of the Unfolded Protein Response CNPY2 ATF4 EIF2A PMC5394057__F1 Cellular mechanisms of radioresistance: (I) the cell cycle checkpoint signaling pathway is a critical progress that allowing times for cells to response to repair DNA damage CDH2 CD44 ATR ATM ABCG2 PMC6678780__F4 Protein network analysis of the overexpressed genes in the TLR non-responsive patient cells CHD8 SMARCD1 SETD2 NUMA1 ANKRD36 CHD9 BMI1 MYL6B MED12 BABAM1 UBL5 RBBP4 BCL7A MIS18BP1 RNF19A SCMH1 ARID2 PCNT ZNF521 NKTR USP24 ANKRD36C MYST4 SMARCC1 EXOC7 CBX2 SIAH1 FBXW9 COMMD3 KLHL3 WDR33 ASXL1 MYL5 EZH2 ILF3 ZNF219 PHIP MDC1 AF1Q MZF1 SNRNP200 BRWD1 ANAPC1 DDB1 PMC5732752__F9 Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle FRS2 HEL-S-162eP GSK3B CCNB1 PMC6804569__F4 Metabolic control of T helper cell differentiation HEL-S-133P IL2 PMC2912031__F4 Reciprocal inhibition mechanism by TGFB and IFNG SOCS1 TGFBR2 STAT1 IFNGR2 IFNGR1 SMAD2 PIAS1 SMAD4 JAK1 TGFBR1 PMC1175050__F1 NFKB pathway regulates inflammation, dendritic cell (DC) development and function, and thymic selection and regulatory T cell production CD40 JUN RELB TRAF6 TNF FOS MYD88 PMC7414992__F1 LT biosynthesis is part of metabolism of the omega 6 polyunsaturated arachidonic acid (AA), which is cleaved from plasmamembranes by phospholipase A2 (PLA2) LTB GPR17 LTA COX1 PMC4291618__F7 IAV facilitates bacterial adherence through the activation of the TGFB signaling pathway TF SMAD2 SMAD4 PMC4466627__F1 Ghrelin receptor controls obesity by fat burning GHSR COX2 UCP1 PMC8040901__F2 Involvement of the autophagy pathway in the phospholipids of exosomes from LnCap cells (Lipid Pathway Enrichment Analysis, LIPEA) ATG12 ATG5 PMC8040901__F3 Lipid Pathway Enrichment Analysis (LIPEA) has shown that the autophagy pathway is involved in the phosphorylation of exosomes from PC3 and DU-145 cells TF SLC3A2 IPP STEAP3 GPX4 LPCAT3 GC FACL4 HEL-S-64p CP ADA PMC6893734__F6 Schematic representation of the regulation of the autophagy-lysosome system in response to severe energy deficit and its modulation by exercise ATG12 CTSO ULK1 ALG13 AMBRA1 BCL2 DLD ATG5 PMC3949417__F1 Sensing of transferrin-bound iron and regulation of hepcidin expression in hepatocytes TF SMAD1 DKFZp781O1323 SMAD4 HFE HFE2 PMC8367056__F4 Desmoplakin and clinical manifestations of desmoplakin cardiomyopathy LATS1 LATS2 CTNNB1 PMC9409255__F3 Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer ATF4 ERO1A EIF2A RPAP2 PMC317132__F1 Model of somatic sex determination in C HSU53209 SDC1 SDC2 SDC3 PMC11641594__F9 Protein–protein interaction (PPI) performed by Ingenuity pathway analysis (IPA) STAT3 PXN HIF1A STAT1 SERPING1 ERG PDCD5 ADAR TRIAP1 TMEM97 HEY2 LRRTM2 TMEM109 EGFR PHACTR2 C1R DACT3 CCNL2 SAMD11 TNS1 APC2 GAS2L3 MEF2C TLE2 FOXH1 COBL APOA4 SMAP OLFM1 ARMCX1 PEAK1 MYL2 RPL27 KDELR2 TLN1 PDZRN3 OPTN CCND1 MAD1L1 ITIH4 AMER2 ITIH2 SERPINC1 ENDOD1 MESD SLAMF8 RPS2 ANKZF1 LGALS7B GZMA F11 CADPS CAMSAP3 GJB1 TCIM ALMS1 TAF8 YPEL3 TAF1 RELA FOXA2 TRIM29 PMC11641594__F7 Apelin signaling pathway with differentially expressed proteins (DEPs) KLF2 PDE3B SMAD4 NOTCH3 PMC11641594__F8 WNT signaling pathway with differentially expressed proteins (DEPs) ROCK2 APC SMAD4 RYK ARHA BAMBI RBX1 SOST INVS RNF43 CBY1 STOM NOTUM CER1 SKP1 NLK PMC4480315__F1 Homocysteine metabolism PMC11641594__F5 Human papilloma virus infection pathway with differentially expressed proteins (DEPs) ATR BAD TRADD STAT2 EGFR APC PTEN IRF3 TERT OASL CDK2 ATM SCRIB GRB2 TBP TYK2 FADD PMC11641594__F6 HIF-1 signaling pathway with differentially expressed proteins (DEPs) TF STAT3 TFRC HEL-S-133P TLR4 HEL-S-162eP EDN1 EPO PFKL MTOR HEL-S-87p VHL PMC1201344__F4 Fasting effects on fatty acid composition FAT4 FAT1 FAT2 FAT3 PMC3077393__F8 GATA2 Mediates Thyrotropin-Releasing Hormone-Induced Transcriptional Activation of the Thyrotropin B Gene GATA2 TSHB TRH PRL PMC9286923__F4 Metabolic Landscape in Osteoarthritis NOS2 SIRT7 ADAMTS4 MMP12 BMPR1A ADAMTS5 NAMPT PTEN MMP9 MTOR SIRT2 MYC PARP1 SOX9 HEL-S-68p MMP3 PC SIRT1 PMC5835092__F4 Ingenuity Pathway Analysis for the interaction between Jab1/COPS5 and PD-L1 STAT3 STAT1 JUN COPS5 S100A8 RELA GSK3B CASP3 HIF1A TNF TYK2 PARP1 PMC5835092__F5 Ingenuity Pathway Analysis to predict the effect of chemical drugs on level of Jab1/COPS5 STAT3 TXN JUN COPS5 NFKB1 SMAD4 PARP1 CTNNB1 PMC7258638__F1 Can respiratory syncytial virus (RSV)-dependent necroptosis be targeted for therapeutic benefit? Simpson and colleagues demonstrate that RSV infection readily induces necroptosis in RSV-infected airway epithelial cells RIPK3 IL25 HMGB1 TSLP MLKL TLR4 IL33 NACA2 RIPK1 GATA3 PMC9025423__F1 Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia FANCE FANCD2 FANCG FANCF FANCM FANCL FANCA FANCC FANCB PMC4225589__F5 Plasmalogen-Biosynthesis Pathway and Associated PhenotypesPlasmalogen synthesis is a multistep process that involves several enzymes GNPAT PEX7 FAR1 PMC4751407__F1 Disc in Flames: Roles of TNFA and IL-1B in Intervertebral Disc Degeneration TRADD TRAF1 TRAF3 TRAF2 FADD PMC5835092__F3 Ingenuity Pathway Analysis (IPA) for Jab1/COPS5 regulation network in cancer STAT3 JUN EGFR COPS5 SMAD4 PTEN HIF1A MIF IL6 CTNNB1 TXN NCOR1 NFKB1 NFKBIA BCL2 PMC4666639__F6 Fn14, a Downstream Target of the TGFB Signaling Pathway, Regulates Fibroblast Activation SMAD2 SMAD4 PMC3656404__F1 Signaling pathways involving PKR-mediated inflammation and immune regulation NLRC4 HMGB1 AIM2 IRF3 ATF2 EIF2A TNF PMC9604018__F7 Pharmacological and Therapeutic Applications of Esculetin FOXO1 DGAT2 FASN PMC8616597__F3 Transcriptome analysis reveals disruption of circadian rhythms in late gestation dairy cows may increase risk for fatty liver and reduced mammary remodeling PER1 CRY2 ADRB2 PMC5292181__F5 Functional interaction network analysis by GeneMANIA of candidate mouse and human genes related to brain metastasis ATAD2 THOC7 TTC28 CXCL12 SLC8A2 POLE2 TIMELESS TNFRSF4 SLC25A13 SLC7A11 HTR2A TNLG2B FKBP5 MSR1 UCN TPH2 TMEM150B VCAM1 MCM2 PLLP CXCR4 POLE PTPRQ RDX PMC4145387__F2 E-cadherin regulated signaling pathways involved in gastric cancer CDC42 CD44 MMP7 EGFR ARHA RHO TNF LEF1 RAC1 CTNNB1 PMC4468369__F7 Illustration for the mechanism underlying s-IL-15RA–induced EMT, migration, and invasion of human RCCs GSK3B SRC CTNNB1 PMC4339202__F6 Metabolic and Chaperone Gene Loss Marks the Origin of Animals: Evidence for Hsp104 and Hsp78 Chaperones Sharing Mitochondrial Enzymes as Clients GPT2 HEL-S-5 LYST PMC7352628__F7 CIGB-300-mediated effects on T-ALL cells JAK3 IL7R PTEN JAK1 PMC6467053__F2 Signal Transduction pathway for STAT3 STAT3 STAT1 EPO JAK1 PMC4326486__F4 Proposed model is that CD146 promotes angiogenesis and mesenchymal cell migration in melanoma ATF3 DVL2 PMC185249__F3 Sprouty is a rapidly inducible negative regulator of fibroblast growth factor (FGF) pathway signaling SPRY2 FRS2 GRB2 PMC7980828__F4 Flavivirus; entry, life cycle, and immune system interaction: (A) Flavivirus infections are generally transmitted through the bite of an infected mosquito or tick SOCS1 STAT1 IRF3 IRF7 IFNA2 FURIN PMC185249__F4 Signal transduction in the Transforming Growth Factor B(TGFB) family pathway is finely regulated at many levels EGF NODAL RHO TNF SKI PMC8762717__F9 PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature NLRP3 IL1B PMC5884924__F9 White adipose tissue browning through reducing tenascin C inflammatory signaling TNC SMAD1 NLRP3 TLR4 BMP4 HOXA5 PMC6731062__F3 Proteins in the glycolysis, tricarboxylic acid, and oxidative phosphorylation pathways examined by the Ingenuity Pathway Analysis software SDHD TH SDHA SDHB COMP ADA PMC3534995__F2 Canonical pathway representing LPS/IL-1-mediated inhibition of RXR function obtained by IPA from the analysis of HT29 data set CYP2B6 PAPSS2 TLR4 CD14 LBP PMC4697050__F3 Signaling pathway of BDNF BAD GRB2 PMC3534995__F3 Canonical pathway representing NRF2-mediated oxidative stress response obtained by IPA from the analysis of SW480 data set JUN RAF1 KEAP1 GSK3B MAPK14 RBX1 MAP3K1 EPHX1 FOSL1 GCLC MAF MAPK7 MAP3K7 MAP2K5 ATF4 MAP2K1 MAP3K5 PMC2947266__F10 The signaling transduction pathway leading to tPA induced fibroblast proliferation GSK3B CCND1 PMC4496222__F7 Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development EGFR GRB2 PMC4003867__F1 Emerging role of Interleukin-22 in autoimmune diseases STAT3 STAT1 JAK1 TYK2 PMC8517511__F2 CBX7 is Dualistic in Cancer Progression Based on its Function and Molecular Interactions BMI1 APC EZH2 JARID2 HDAC2 PMC8602812__F3 Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites ACLY CD80 CAD CD163 PMC8602812__F4 Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites ACLY TH CD80 ROS1 CAD CD36 PMC6975965__F4 ERBB2 signaling depicting actionable targets ERBB3 EGFR ERBB2 MTOR PMC3756346__F2 Map of the molecular mechanisms of apoptosis HTRA2 NAIP CASP9 BAD FAS TRADD CASP10 DIABLO FADD PMC9484255__F4 Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response ARID1A ATR CGAS ATM PMC9237231__F4 Regulation and Modification of GSDMD Signaling in Diseases NINJ1 GSDMD RIPK1 FADD TRIM21 PMC4090452__F2 Integration of the proposed pathways by which the NTPDase5/mt-PCPH acts on the neoplastic progression PTEN MTOR PMC7515865__F3 PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers BAD MTOR EIF4E PMC7515865__F1 PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers RHEB TSC2 TSC1 BCR PTEN PMC4070062__F3 Cytosolic nucleic acids sensors and autophagy ESX1 CGAS IRF3 PMC4070062__F1 TLRs and autophagy FER TLR4 TLR9 NOD2 IRF7 TLR7 NOD1 MYD88 PMC3971994__F1 HGF/Met receptor signaling pathway HGF GRB2 PMC3858246__F1 Canonical WNT/Beta-catenin signaling and inhibitors LEP APC CTNNB1 PMC8640016__F8 FUT8 negatively regulates NFKB2 signaling by blocking the activation of TNFR FUT8 BCL2A1 NFKB2 TNF FADD PMC8947839__F4 Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review FOXO1 MMP9 IL1B PMC5259907__F2 The network of cell apoptosis regulation induced by DNA damage BAX ATR ATM PMC5259907__F4 Network constructed based on BAX CASP9 CASP8 FOXO1 EGFR CASP3 ATM MYC FADD PMC7687032__F3 Blood–brain barrier integrity by microglia in health and disease: A therapeutic opportunity TREM2 SYK TREM1 APOE MTOR PMC3510123__F7 Eliminating the SLAC1 anion channel affects K+ channel activity, K+ uptake, and the rate of stomatal opening through its impact on and as predicted by the OnGuard model (; ) CRH MAL PMC3652804__F1 Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity PIK3CA SHC1 AKT3 IGFBP1 PIK3R1 IGFBP4 IGFBP2 IRS4 PTEN GH1 INS GHRHR IGFBP6 IRS1 IGF1 IGFBP5 INSR PDPK1 GHR PMC5749725__F2 Identification of metastasis driver genes by massive parallel sequencing of successive steps of breast cancer progression MAPK1 SMAD4 GIP IGF1R ARHA OTP LMO7 CTNNA3 CTNNA2 INSR FER ERBB2 NLK PMC9393500__F1 Biosynthetic approaches to efficient assimilation of CO2 via photorespiration modification in plant chassis HYI PMC10932467__F2 Possible effects of IL-6 signaling on energy intake and energy expenditure under non-obesogenic conditions STAT3 UCP1 ATM PMC4508517__F4 Uses of CRY2 domains RAF1 CRY2 PMC8635802__F4 Kinase Inhibition as Treatment for Acute and Chronic Graft-Versus-Host Disease TH PLCG1 APC PMC2911016__F1 “Go upstream, young man”: lessons learned from the p38 saga MAPKAPK2 ATF2 PMC2921576__F1 Schematic representation of hepatic methionine metabolism NNMT HEL-S-182mP HEL-S-61p PMC5508527__F2 Metabolic reprogramming and tolerance during sepsis-induced AKI TNF SIRT1 SIRT6 PMC6001073__F5 The gene or protein expression of GLUT1, HK1, PGM1, UGP2, GALT, GALE, SLC35A2, LALBA, and B4GALT1 on the lactose synthesis pathway throughout lactation GAL B4GALT1 SLC35A2 LYZG PMC5508527__F3 Metabolic reprogramming and tolerance during sepsis-induced AKI RHEB TSC2 TSC1 STAC TNF SIRT1 SIRT6 PMC5988853__F2 Interplays of interleukin-23 (IL-23), IL-6, signal transducer and activator of transcription 3 (STAT3), and retinoid-related orphan receptor Gt (RORGt) in the differentiation of pathogenic T helper 17 (Th17) cells STAT3 CCR6 CCL20 TYK2 PMC8160894__F6 TAK1/AP-1-Targeted Anti-Inflammatory Effects of Barringtonia augusta Methanol Extract TLR4 CCL2 MYD88 MAPK3 PMC6608034__F3 MTORC1 pathway: effect on TLR signaling cascades and modulation by bacteria STAT3 TSC2 TSC1 MYD88 PMC3073693__F4 Molecular pathways in dystonia THAP1 EIF2A PMC11880140__F2 Roles of five types of decidual innate immune cells in the regulation of labor initiation and PTB RAG1 PMC7265991__F1 Intersection of radiation and the tumor immune microenvironment HMGB1 CGAS CD36 PMC3328908__F9 Diagram of canonical tight junction signaling pathway PTEN CASK HEL-S-11 PMC3670239__F1 Infection-induced IL-10 and JAK-STAT SOCS1 STAT3 STAT1 CD14 SOCS3 JAK1 TYK2 PMC8422077__F2 Depiction of genetic dependencies in cancer EGF EGFR BRAF VPS4B VPS4A PMC8834883__F1 Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions ATG3 ATG12 ULK1 MTOR ATG5 ULK2 PMC8001445__F4 Metabolomic map of flor yeast gluconic acid consumption MAL PC GIP CIT PMC8834883__F3 Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions ATG16L1 ATG12 ATG14 PTEN MTOR ATG5 PMC6529190__F10 Adiponectin-mediated signaling pathway in HSCs DNMT3B APPL1 ADIPOR1 ADIPOR2 PTEN PMC7662373__F1 The hypoxia pathway under normoxia and hypoxia TF STAT3 VHL PMC6027421__F2 Steroid biosynthetic pathway CYP21A2 CYP17A1 CYP11A1 PMC8427689__F6 Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment SYK MATK MYB BAD GAL RBL2 PTEN CD19 SHE RAC1 TSC2 BRCA1 BCR GRB2 PMC11747879__F2 Activin signalling pathway FSTL3 SMAD2 SMAD4 PMC4156532__F9 Sestrin2 Promotes Unc-51-like Kinase 1 (ULK1)-Mediated Phosphorylation of p62/sequestosome-1 TBK1 KEAP1 ULK1 SESN2 PMC11894105__F2 Molecular mechanisms of apoptosis pathway activation BAX FAS TRADD FADD PMC4942281__F2 Oncogenic survival signaling components in PCNSL STAT3 CXCL12 IL10 CXCL13 PIM1 IL4 IRAK1 MYC MYD88 BTK BCR TLR4 BCL2 JAK1 PMC11894105__F3 TNF-induced necroptosis signaling pathway TRADD MLKL TRAF5 CYLD TRAF2 FADD PMC7023707__F1 Kynurenine pathway and tryptophan metabolism in the central nervous system HEL-S-90n KYNU KMO PMC12183064__F6 Molecular mechanism of ERA36-mediated protection against HG-induced apoptosis and senescence BAX CASP3 EZH2 PTEN PMC6426753__F1 Complement pathways HEL-S-62p CFI C2 C1S CFH CS CR1 PMC3890654__F1 Toll-like receptor-4 signaling pathway SOCS1 JUN TLR4 TAB3 MAL CD14 SIGIRR IRAK2 TRAF6 FOS MYD88 PMC3890654__F2 Negative regulators of toll-like receptor-4 signaling pathway by Lactobacillus jensenii TL2937 in porcine intestinal epithelial cells and antigen presenting cells JUN TLR4 TAB3 MAL CD14 SIGIRR TNF FOS PMC7865493__F1 Aryl hydrocarbon receptor (AhR) signaling pathways: canonical (A) and noncanonical (B) IF2B1 KLF6 EGFR AHR STC2 IL6 IL1B PMC11894105__F5 Molecular mechanisms and regulatory networks of ferroptosis TF STEAP3 GPX4 LPCAT3 FACL4 HEL-75 PMC7865493__F2 Molecular interactions within the AhR signaling pathway HMOX1 NQO1 AHR FLG CYP1A1 OVOL1 PMC6620896__F3 Conceptual model of cellular processes within Tv SAT2 ARX PMC12160515__F2 Possible signaling pathways in inflammatory-oxidative stress mediated neural regeneration BAD KEAP1 PTEN BDNF PMC3393719__F8 Yeast Magmas Ortholog Pam16 Has an Essential Function in Fermentative Growth That Involves Sphingolipid Metabolism PHB2 SAP30 PMC6027492__F2 Mitochondrial protein lipoylation GCSH FAS LIPT2 LIPT1 LIAS PMC4459582__F7 Kruppel-like factor 5 is required for perinatal lung morphogenesis and function TGFBR2 BMPR2 ACVR1 PDGFRA BMP2 PTGS1 ACVR1C KLF5 AMHR2 SEMA3B FGF18 FGFR2 PMC4905194__F2 Mechanisms of gap filling RAD18 RAD51 PCNA POLE RMI1 PMC4828451__F5 Complement activation pathways MASP1 C6 CD59 FH C7 HEL-S-62p C2 C9 C4A CR1 PMC6549747__F1 Signaling pathways implicated in different categories of breast cancer EGFR APC FGFR1 LRP5 KIT LRP6 IGF1R GRB2 MTOR CTNNB1 PMC6549747__F2 Interaction between tumor microenvironment components, including stromal cells, and tumor cells leads to enhanced cell growth, proliferation, angiogenesis and invasion FUS CDK6 MYC CYP3A4 CCND1 CDK4 PMC4682245__F5 DEGs involved in JNK pathway in Tg(RE:HSE:EGFP) MAX JUND ATF2 FLNA MEF2C PMC4772696__F3 Role of EZH2 in genomic signaling through canonical and non-canonical activity TF SUZ12 EED PMC3819741__F2 Identification of the genes in the MAPK signaling pathway that harbor or are in the close proximity of SNPs associated with feed efficiency MAX ECSIT NGF JUN FAS SPR CD14 HEL-S-11 ATF2 DAO PMC4084561__F2 Regulation of type I interferon responses CXCL9 STAT3 STAT1 SIN3A STAT2 IFNAR2 IFNAR1 IRF1 MX1 JAK1 TYK2 PMC4084561__F3 Regulation of type I interferon responses SYK STAT1 AGO2 STAT2 USP18 JAK1 TNF TYK2 PMC2842130__F9 Redoxosomal signaling for IL-1B and TNFA pathways IL1R1 TRADD TRAF6 TNF TRAF2 HEL-S-44 MYD88 PMC3236512__F2 Effect of FXR activation on triglyceride and cholesterol metabolism in the liver PCSK9 LPL TG NR1C1 ABCG8 ABCG5 HMGCR VLDLR PON1 LDLR APOB PMC8654299__F1 CoQ biosynthetic pathway of plant and the coexpression network IPP COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 PMC3151543__F2 Schematic depiction of how complement modulates T-cell immunity CD40 CD80 FAS HEL-S-62p APC BCL2 PMC4505959__F10 The molecular events leading to the production of IL-10 in macrophages exposed to S EGR1 ACO2 TIRAP TLR4 NFKB2 ADPGK NDUFA10 FOS MYD88 PMC2924648__F3 Directed cell migration PAK1 EGFR APC PTEN DOCK2 PMC7644914__F1 The underlying molecular mechanisms influencing the protein synthesis, degradation, and dynamic trafficking processes of ASIC1a NGF BDNF IL1B PMC3513219__F2 XRCC1 is instrumental in base excision repair (BER) of small oxidative lesions and a related mechanism for the repair of single-strand breaks (SSB-R), both caused by ionizing radiation OGG1 PNKP PMC12174687__F3 Nectin-4 signaling in normal and malignant cells CDH2 CXCL12 TIGIT CXCR4 PMC6217754__F1 IL-32-induced signaling pathway activation in macrophages STAT3 COX2 IL16 CXCL1 CXCL2 PMC7820759__F4 Schematic view of the molecular network and functions of human papillomavirus (HPV) E5, E6, and E7 oncoproteins in HPV-induced cancers PRMT1 STAT3 OGT EGFR KDM6B FOXM1 NHERF1 HLA-E CDK6 CARM1 E2F4 E2F6 CDK2 CDK4 PMC4867367__F4 GR cross talk with the TLR signaling pathway TBK1 GRIP1 MAL TANK IRAK1 IRF3 IRAK2 TRAF3 TRAF6 HDAC2 IRAK4 MYD88 PMC5777349__F9 SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis STAT3 APLN IL6ST CCL2 PMC6949885__F15 Molecular mechanism by which miR-601 downregulation inhibits the proliferation, migration and invasion of PCSCs by activating KRT5, and subsequently inhibiting the Wnt signaling pathway GSK3B WNT1 CTNNB1 PMC5296320__F2 Schematic representation of the role of pancreastatin (PST) in the regulation of insulin secretion from pancreatic beta cells GC GOPC GCK PMC4867367__F5 Cross talk of GR with the STAT signaling pathway STAT3 SRC PMC6103460__F1 Major Nai influx and efflux pathways and metabolic pathways involved in ATP supply CD36 MCU CPT2 NACA PMC5932189__F3 Myeloid C-type lectins and heterologous receptors SYK IRF1 MDM2 MTOR CARD9 MYD88 PMC8830302__F1 Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy IFNG HIF1A CTLA4 FOXP3 LAG3 PMC6430726__F7 Down-regulation of miR-543 expression increases the sensitivity of colorectal cancer cells to 5-Fluorouracil through the PTEN/PI3K/AKT pathway BCL2 PTEN PMC3532179__F1 Mathematical model of the apoptotic pathways induced by cisplatin BAX CASP9 ATR CASP3 PMC8000754__F4 Proteasome inhibitors and metabolic pathways SIRT3 HEL-S-133P NAMPT HIF1A ATF4 PMC11120609__F1 Metabolic pathway of cyclophosphamide CYP2B6 CYP2C19 CYP2C9 CYP3A4 PMC9389016__F7 Integrated network pharmacology and hepatic metabolomics to reveal the mechanism of Acanthopanax senticosus against major depressive disorder AMY1A GAA PYGM DAO MAOA PMC11552210__F2 Molecular pathways involved in the increase of fibrosis in the ovary and uterus by exposure to micro/nano plastics HMGB1 TLR4 SMAD2 MMP2 MMP9 PMC3978192__F2 Pathophysiology and pharmacology of hepcidin STAT3 SMAD1 TFR2 DKFZp781O1323 HFE IL6R HFE2 PMC6306333__F5 Proposed working model IL16 CXCL8 IL1B PMC6982102__F2 Ceramide is the central molecule in sphingolipid metabolism and can be synthesized by three different pathways: de novo synthesis pathway, sphingomyelinase pathway and salvage pathway CERK SMS tmp_locus_29 KDR PMC3575845__F7 Anti-quiescence network mediated by the Myc-miR-22 pathway HMGB1 TP53INP1 CARF MXD4 MYC PMC8025348__F2 Main mechanism of F TIGIT EGR1 TLR4 TNF IL1B CTNNB1 PMC5111721__F3 NAD+ metabolism is compartmentalized SIRT3 NMNAT1 SIRT4 SIRT5 NAMPT NMNAT2 SIRT2 SIRT1 SIRT6 PMC4695008__F6 Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2A/androgen receptor signals CCL5 CXCR4 VHL PMC1952649__F2 Two tales concerning skeletal muscle IGF1 IGF2 PMC11760605__F2 This diagram represents a schematic overview of the MAPK pathway, comprising three principal activation branches: RTK, ERK, JNK activation nodes STAT1 RAF1 MAPKAPK2 MAPKAPK3 MAPKAPK5 ATF2 IL6 GRB2 PMC8208723__F10 Root meristem size reduction and stem cell death in response to DSBs ATM PIN4 PIN1 PMC8102120__F1 Pyroptosis: A New Frontier in Kidney Diseases GSDMD NLRP3 IL16 AIM2 PMC3538647__F1 Metabolic map of the purine biosynthetic pathway PURA PURB PMC6688195__F1 Key intrinsic immune evasion mechanisms exploited by HPV oncoproteins in keratinocytes (KCs) CGAS STAT2 IRF9 TLR9 EZH2 TAP1 TRAF3 CXCL14 CD1D HEL-117 ME3 HDAC1 STAT1 PMC5935098__F3 Hippo Signaling Circuit and Divergent Tissue Growth in Mammalian Eye RPE SOX2 NF2 PMC8380402__F10 NCAPG promotes the progression of lung adenocarcinoma via the TGFB signaling pathway TF CDH2 NCAPG SMAD2 SMAD4 PMC3882710__F8 The potential role of MuRF1 in atrophy induced gene expression pathways MYOG CHRNG COL1A2 PNPLA3 ENO3 HEL-S-133P c-fgr PIK3R1 MEF2C PMC3674015__F1 (A–C) Schematic overview of particle-based vaccines CD40 PMC8908994__F2 Noncoding RNAs in Cardiac Hypertrophy and Heart Failure HOXA9 PLEKHM1 MFN2 IKBKE GATA4 MYD88 PMC4305955__F1 Fibronectin-related signaling pathway graph stored in HBVPathDB CSK RHO SRC PMC3248179__F2 Evi1 forms a bridge between the epigenetic machinery and signaling pathways RHEB TSC2 PTEN PDK2 PMC4331626__F4 Depiction of various pathways that are known to contribute to eEF2K regulation in systems biology graphical notation (SBGN) activity flow format () EEF2K TSC2 TSC1 EEF2 PMC8298820__F2 Glycyrrhizic Acid: A Natural Plant Ingredient as a Drug Candidate to Treat COVID-19 HMGB1 ACE2 PMC9367289__F1 Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells: Opportunities for Targeted Therapy SUFU SHH SMO PMC5903825__F1 Hepcidin regulation and action in non-cancerous tissue ERFE TFR2 HFE PMC4128256__F7 Models of Ras signaling in NF1-deficient GBM cell lines NF1 PTEN MTOR PMC2593023__F1 Unexpected pieces to the senescence puzzle EBP BRAF IGFBP7 IL8RB PMC4598780__F1 DNA damage response activates cell cycle checkpoint TOPBP1 ATR ATRIP H2AX WEE1 ATM GADD45A MDC1 CDC25B PMC5325323__F3 Neural tube closure: cellular, molecular and biomechanical mechanisms SMAD1 DKFZp781O1323 BMP2 SHH ARHA HP RAC1 PMC8156813__F5 Sildenafil Alleviates Murine Experimental Autoimmune Encephalomyelitis by Triggering Autophagy in the Spinal Cord MTOR BDNF ATG5 PMC8998017__F1 STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments CGAS IL6 ENPP1 PMC9103444__F3 Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer BAX MCL1 PMC6385449__F13 miR-506 inhibited the expression of LHX2, which hampered TCF4 expression and inactivated the Wnt/Beta-catenin signaling pathway, consequently inhibiting tumor growth and metastasis in NPC TCF4 CTNNB1 PMC11673094__F7 Targeting to insulin resistance is illustrated and summarized TLR4 TRAF6 IRS1 MYD88 PMC9103444__F8 Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer CDK12 PMC5944225__F9 Magnoliae Cortex and maize modulate Porphyromonas gingivalis-induced inflammatory reactions STAT3 COX2 IL1B PMC11673094__F5 Targeting to maintain mitochondrial function is illustrated and summarized OPA1 MFN1 MFN2 SIRT1 PARP1 PMC10490091__F7 Anti-Inflammatory Effect of Meriania hexamera Sprague by Targeting Syk Kinase in NFKB Signaling SYK TLR4 SRC MYD88 PMC11673094__F3 Targeting to attenuate the inflammation is illustrated and summarized HEL-S-31 PTX3 ACSL3 NLRP3 TXNIP TLR4 TRAF6 NOX4 MYDGF IL1B MYD88 PMC11673094__F4 Targeting to attenuate the ROS is illustrated and summarized SIRT3 GLP1R NOX4 PMC11673094__F1 Potential molecular pathways of fatty acid, especially PA-induced vascular endothelial dysfunction, are illustrated and summarized—PA uptake by endothelial cells through fatty acid transporter or passive diffusion PTX3 CYR61 NLRP3 OPA1 MFN1 TLR4 MFN2 TRAF6 NOX4 PARP1 IRS1 MYD88 PMC8684233__F3 Ferroptosis in urologic malignancies PANX2 GPX4 HEL-S-102 MTOR PMC5022081__F1 Post-translation processing of Klotho protein ADAM17 ADAM10 CS PMC8660617__F9 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients CDC2 ATR CDC20 RASSF1 CDC6 APC BRCA2 CDK2 ATM PTEN PLK1 SKP2 PMC11673094__F2 Targeting to attenuate the programmed cell death is illustrated and summarized PTX3 NLRP3 SIRT1 PMC3338196__F3 Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation MAL PC CIT PMC2972986__F1 Biological processes known to be stimulated in an AHR-dependent and/or AHR-independent manner by the tryptophan photoproduct FICZ AHR CYP1A1 PMC3839581__F1 Insulin Biosynthetic Interaction Network Component, TMEM24, Facilitates Insulin Reserve Pool Release C2CD2 IQGAP1 GIP HAPLN4 ATXN2 MAP2 INS TUBA1B PSMD2 DST PSMD1 ERC1 CLASP1 CLASP2 PXDNL PLAT ARFGAP3 TUBA4A PPFIBP1 MYO1C ARMC10 KIFC1 DMXL2 PXDN DMD ARHGEF2 PFKM APC MIF IGF2 NAGA DNAJB11 PFKL PMC4963802__F1 Wnt signaling pathway RNF43 APC LRP5 LRP6 GPR49 LGR6 PMC11475825__F4 IPA analysis of the signaling networks between AhR signaling and NRF2 signaling CYP1A2 CDKN1A AHR EP300 CYP1A1 PMC1774670__F2 Interaction of JC virus (JCV) T-antigen with key growth regulatory pathways MDM2 CCND1 IRS1 CTNNB1 PMC10310980__F1 Circadian clocks in cancer: Mechanisms and clinical implications CD44 BAX CRYZ CRY2 CRY1 GC MTOR PMC5547743__F7 Proposed model for I-SMAD-regulated signaling that enhances HSPG expression, cholesterol uptake and HCV entry BMP6 CD81 ALK VLDLR EGFR SMAD6 LDLR BMP7 PMC1774670__F6 P53 pathway BAX PCNA MDM2 PMC11475825__F2 Actin mechanism of the NRF2 signaling pathway UGT1A1 KLF4 ABCB6 JDP2 GPX4 GCLM SOX2 HIF1A IL6 BMP6 GCLC NOTCH1 HEL-S-44 PMC4257089__F1 In silico modeling of a CD4+ T-cell CDC42 RAF1 SHC1 LAT EGFR PTEN TGFBR1 BTK BCL10 INSR APP ITK SRC CAV2 AQP3 PLD2 NEU3 NGFR PTPN1 PTPN11 BMX PTGS2 GJB2 PTPN6 CSK GRB2 LCK PMC9250486__F4 Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited MTOR CTNNB1 PMC5571780__F1 Small GTPases in endothelial barrier regulation RASIP1 ARHA ARHGAP29 CTNNB1 RADIL PMC5869671__F1 NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival CD40 GBF1 FBXL15 LTBR RELB PMC2945208__F1 KEEPING AN EYE ON RETINOBLASTOMA CONTROL OF HUMAN EMBRYONIC STEM CELLS CDK6 CDK2 PMC2945208__F3 KEEPING AN EYE ON RETINOBLASTOMA CONTROL OF HUMAN EMBRYONIC STEM CELLS CDK6 E2F3 SOX2 CDK2 PMC1959234__F1 Schematic model for the "error-free" BRCA double strand break repair pathway Brief overview of components within the BRCA pathway used here as a working model that was tested here RAD50 MRE11A BRCA1 BRCA2 CHEK2 ATM PMC11703838__F2 Signaling pathways in TCSCs STAT3 KDM1A MAML1 KIF7 SUFU APC SOX2 SMO CTNNB1 GLI3 PMC8722734__F3 Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases KLLN FOXO1 FOXO3A DEDD MCM6 PMC5474494__F2 Phagocytosis mediated by receptors CDC42 TREM2 SYK PIR IRAK4 PMC5301133__F4 Protein interactome involved in neuroendocrine neoplasm proliferation.Proliferative signaling includes a tightly regulated signaling interactome (including RAS/RAF, MAPK, and PI3K/Akt) PIK3CA JUND RASSF1 EGFR AKT3 BRAF PTEN MAP3K11 MTOR TGFBR1 TGFBR2 MDM4 CDKN2A NF1 MDM2 MAPK1 JUNB KRAS FOS HRAS TSC2 RICTOR TSC1 VIPR2 RRAS MAP2K1 MAP2K2 AKTIP RRAS2 MAGED2 PMC2867937__F12 Segment-Specific Neuronal Subtype Specification by the Integration of Anteroposterior and Temporal Cues ST14 ST13 PMC5301133__F2 Mechanistic basis of secretory regulation in a neuroendocrine cell ADCYAP1R1 ADORA2A DRD1 CCK DRD2 PMC11703838__F5 Crosstalk between TCSCs and immune cells STAT3 CSF1 SIGLEC15 WNT3A CCL15 SIRPA WNT1 IL6 CCL2 CD47 PMC7268289__F7 Pathway bar plot explanation and pathway map explanation EIF4B BAD TIRAP CTSK PTEN IRF3 MTOR TNF TRAF6 IRAK4 EIF4E RHEB TLR3 BCR CASP3 PIR LBP FADD PMC8580862__F9 Immune-Related Molecular Profiling of Thymoma With Myasthenia Gravis STAR CDC20 PCNA SMAD2 SMC3 CD7 SMAD4 CYC1 MYLIP SKP2 MYL1 CDK7 E2F4 CDC45 CDK2 MDM2 PMC6025837__F6 Thyroid hormone signaling pathway RHEB CASP9 TSC2 BAD RXRA PFKFB2 PTEN MDM2 MTOR RXRB CTNNB1 PMC8870356__F1 Integrins in Modulating Smooth Muscle Cell Plasticity and Vascular Remodeling: From Expression to Therapeutic Implications EGFR GSK3B SRC CTNNB1 PMC5664393__F7 B-cell activating factor (BAFF)-BCR crosstalk in chronic lymphocytic leukemia (CLL) cells STAT3 SYK BTK BCR RELB LYN TRAF2 PMC6775706__F1 Cyclin D-CDK4/6-INK4-Rb pathway in breast cancer CDC2 CDK6 CDC6 CDK2 CCNA2 ORC1L CCND1 CDK4 PMC6775706__F2 Signaling pathways associated with tumorigenesis and combined treatments that alleviate drug resistance CDK6 EGFR BMP4 CDK2 MTOR CCND1 IRS1 CDK4 PMC6437095__F2 Interaction between miRNAs and TGFB pathway in GC LOX SMAD2 GC FSHR PMC6437095__F3 Interaction between miRNAs and FSH pathway in GC AKT3 GRB2 MTOR BDNF FSHR LHCGR PMC6437095__F4 Interaction between miRNAs and apoptosis pathway in GC NGF BAD FAS MAP3K1 TRADD IGF1 SMAD2 GC TNF TRAF2 SIRT1 FADD PMC11931041__F2 Diagram of the PI3K/AKT/mTOR (PAM) signaling pathway MLST8 TSC2 RICTOR TSC1 KEAP1 PTEN PDK2 DEPTOR NDFIP1 PMC4645220__F13 Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway LIMK2 LIMK1 MMP2 MMP9 PMC8859176__F10 Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation KDM4A EZH2 BDNF PMC5633884__F7 Elevated expression of Par3 promotes PCa metastasis via Hippo pathway inactivation FRMD6 TWIST1 PMC12252150__F2 Molecular mechanism of ERF3, SR4, DRM6-1, CHL1, NRL1, PM1, DMP2 and their role in resistance to P SWAP70 NRL PMC9414081__F10 Research progress on extraction technology and biomedical function of natural sugar substitutes HMGCR TRPM5 LDLR PMC9414081__F11 Research progress on extraction technology and biomedical function of natural sugar substitutes FASN GSK3B CPT1A PMC11555290__F2 Decoding tumor-fibrosis interplay: mechanisms, impact on progression, and innovative therapeutic strategies EGFR IL33 AREG PMC12025727__F5 Signaling pathways activated by AEG-1 in HCC STAT3 CTBP2 EGFR APC PTEN IL6 MYC LEF1 CTNNB1 PMC11555290__F1 (By Figdraw, ID: RASTR41933) Mechanism of fibrosis promotion by malignant tumors: Tumor cells secrete pro-fibrotic factor TGFB and activate CAFs through the TGFB/Smad signaling pathway SMAD2 SMAD4 PMC12025727__F3 Mechanisms by which AEG-1 induces MASH NR1C1 FASN TRAF2 PMC8433920__F5 Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities CDC2 CDC42 BAX SUZ12 BAD PCNA EGFR EZH2 MMP9 MTOR RAC1 CTNNB1 CDK6 FOXO4 MMP2 CDK2 SRC CDK4 PMC5201051__F7 Schematic depiction of aspects of adult olfactory GBC regulation BMI1 OMP ASCL1 SMAD2 NEUROG1 SOX2 HES1 PMC4926504__F1 Signaling mechanisms of epidermal growth factor receptor (EGFR) transactivation in renal fibrosis EGFR SMAD2 SRC PMC5742019__F1 Metabolic Strategies of Melanoma Cells: Mechanisms, Interactions with the Tumor Microenvironment, and Therapeutic Implications ACLY GLS HK2 FASN BRAF PTEN HIF1A MTOR MYC MTHFD1 PHGDH SHMT1 NRAS HEL-S-26 PMC7945361__F6 Proposed relationships of amphotericin biosynthesis with relevant metabolic pathways in S MAL DAP CIT PMC6063915__F2 PPAR Signaling Pathway and the Terpenoid Backbone Biosynthesis Pathway EHHADH MSMO1 EBP DHCR24 PLK1 ACADM ACAT1 CYP7A1 IDI1 FDPS HSD17B7 CPT2 TM7SF2 UBB LPL GGPS1 CYP51A1 ACOX1 SQLE MVK HMGCS1 HMGCR RXRA PMVK MVD FDFT1 PMC6063915__F3 LSEC and KC signaling pathways in 3DHLK systems ACOX1 EHHADH ACSL6 ACSL5 ACSL3 CYP8B1 FCER1A ACADS APOE FACL4 DHCR24 ACADM PCSK9 ACAT1 NR1C1 HMGCR ACAT2 CYP7A1 LDLR FDFT1 GAB2 CYP27A1 PMC3423502__F6 Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud DKK1 SPRED3 TBX6 PMC1679905__F6 Signalling routes emanating from the epidermal growth factor receptor (EGFR) EGF EGFR GRB2 SHE PMC3589096__F2 SREBP activation and input from mTORC1 signalling SREBF2 PMC3897773__F7 Regulation of Amyloid Precursor Protein Processing by Serotonin Signaling APP IPMK SRC PMC209288__F1 The biosynthetic pathway for the fibrillar collagens expressed in skin, identifying steps that are affected in different forms of EDS COL1A1 COL1A2 COL3A1 PMC3661399__F7 Selected AMPK and IGF-IR signalling pathways relevant to this study in normal (A) and hyperglycaemic (B) conditions TSC2 MTOR IRS1 PMC9556450__F2 Drug transport across the blood-testis barrier CDC42 RPS6 F5 PMC3295081__F1 Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models TLR4 JAK1 MYD88 PMC9505027__F1 MicroRNA: A Linking between Astrocyte Dysfunction, Mild Cognitive Impairment, and Neurodegenerative Diseases CDC2 MAPK1 SP1 IL13 SMAD2 GSK3B IRAK1 PTEN IRF7 MTOR PDK2 TNF TRAF6 RAC1 MDM4 STAT1 CDK6 IGF1 COX2 E2F4 NFKB1 MDM2 PMC8669491__F3 Altered protein secretion in Batten disease HEL-S-130P CTSA CLN3 TPP1 PMC8035226__F2 Metabolism of multiple substrates supports acetyl-CoA production in the fat cell ACLY ACSS2 FASN PMC10778207__F4 Src intracellular signaling pathway and various cellular processes controlled by each pathway STAT3 ARHA GRB2 MTOR SRC PMC5552707__F8 Network analysis of the gene pathways* catalogued in the Panther database, which - directly or indirectly - are connected with AD upon activation with Hp(2-20) GSK3B MAPK8 MAPK3 PLCG2 PDPK1 NRAS SRC NOTCH1 FRS2 APOE LRP6 ARPC1B EIF4E PPP6C ERBB3 NEK1 ACTR2 EIF4G1 PRKCI TCF7L2 FPRL2 ADAM9 MAP3K1 PRKCQ SOS2 IFNAR1 PSEN2 FPR1 PRKX FPR2 PPP4C CTNNA1 APBB2 SOCS6 WNT10B FZD5 ARPC4 ACTL8 ARHG MAPK13 ARPC2 ARPC3 IKBKE RPS6KB2 BRAF PKN2 LRP11 PTEN CTNNB1 PRR5 MAP2K4 ADAM17 RASA2 APP JUN PLD2 SPRY4 RBPJ NFKB1 RELA PIAS1 REL PMC10886920__F1 Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma STAT3 STAT1 RAF1 AXL MMP9 MTOR PMC3447932__F10 Vsx2 Controls Eye Organogenesis and Retinal Progenitor Identity Via Homeodomain and Non-Homeodomain Residues Required for High Affinity DNA Binding OTX1 VSX2 PMC3438665__F1 p53-dependent and -independent therapeutic strategies for cancer cells MDM2 MTOR PRIMA1 PMC10379333__F3 Pulmonary Sarcoidosis: Experimental Models and Perspectives of Molecular Diagnostics Using Quantum Dots TSC2 MTOR CCL2 ABCA1 PMC7593515__F2 YAP/TAZ by core components of Hippo signaling pathway LATS1 LATS2 AXL NF2 PMC6620386__F8 microRNA-613 exerts anti-angiogenic effect on nasopharyngeal carcinoma cells through inactivating the AKT signaling pathway by down-regulating FN1 MTOR PMC8683078__F2 Biofactoid data is connected to information sources and establishes a bridge between related pathways CDC2 CSA2 JUN NR1D1 SIRT5 PML UCP1 ATF2 MEF2C CRTC1 MGA ACSS2 HDAC1 SIRT3 GLUD1 SUMO1 SUMO3 SUMO2 CDKN1A SENP1 HEL-S-11 PAH PMC3513366__F1 Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells CD44 STAT3 TG MSI1 DCLK1 PI3 APC BRAF HP CTNNB1 PMC7593515__F3 Hippo signaling pathway and potential inhibitors of YAP/TEAD LATS1 BRD4 LATS2 HEL-S-62p AMOT RHO GRB2 IRS1 PMC8124199__F2 JAK/STAT Molecular Pathway in Vascular Remodeling Associated with Pulmonary Hypertension STAT3 STAT1 JAK1 TYK2 PMC8124199__F3 JAK/STAT Molecular Pathway in Vascular Remodeling Associated with Pulmonary Hypertension HEL113 MMP9 PMC5944149__F2 The overexpression of tRNAs regulated the progression of cancer acting on different ways: Ras, c-myc and TERT promoted the transcription of tRNA genes by binding to pol III ERBB3 ERBB2 TERT PMC6815315__F3 GSK3 regulates cell death, renewal, and differentiation IGF1 MCL1 APC IRS1 CTNNB1 PMC7667862__F9 Model for OTUD7B deubiquitination of TRAF3 and inhibition of NIK to suppress LCL161-induced lung cancer cell invasion and migration CD40 OTUD7B RELB TRAF3 PMC9291723__F1 Ferroptosis in Acute Kidney Injury TF FTH1 GPX4 NQO1 LPCAT3 BAP1 DPP4 FACL4 ALOX15 PMC6815315__F1 GSK3b and growth regulation RHEB IGF1 APC MTOR IRS1 PMC8514750__F4 GTPase-Dependent Mitochondrial Dynamins in Heart Diseases CDC2 SIRT3 SUMO3 SUMO2 SIRT1 PMC8514750__F5 GTPase-Dependent Mitochondrial Dynamins in Heart Diseases SIRT3 OPA1 OMA1 PMC8226626__F1 JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms STAT3 STAT1 EGF IL13 JAK3 IL4 IL11 IL6 IL31 TYK2 PMC3414439__F4 Combinatorial Drug Discovery Using Transcriptional Response Modules KCNE1 CAV3 GNAI1 CASP3 PRKCA SRC MAP2K3 TOP2A MAPK3 PMC3677821__F2 Schematic showing some major pathways implicated in cancer progression using Drosophila studies COMP CSK SCRIB SRC MYC PMC8924142__F1 Type I interferon-mediated tumor immunity and its role in immunotherapy STAT1 STAT2 IFNAR2 IRF9 IFNAR1 MTOR JAK1 TYK2 PMC8924142__F2 Type I interferon-mediated tumor immunity and its role in immunotherapy HMGB1 CLEC9A TBK1 CGAS TLR9 IRF3 IRF7 SLC19A1 MYD88 UNC93B1 ZBP1 TLR3 TICAM1 TLR4 DDX41 PMC1193534__F1 Comparative Genomics of Natural Killer Cell Receptor Gene Clusters DAG1 LCP2 SHC1 KIR2DL1 LAT PTEN VAV1 GRB2 SRC PTPN6 PMC4691064__F5A Transcriptomic Response to Nitric Oxide Treatment in Larix olgensis Henry RPS5 FRK HEL-S-11 PMC7316979__F3 Interaction networks from significantly upregulated serum cytokines from cancer survivors CRP EGF CXCL12 TFR2 CXCL5 PLAUR PDGFA IL1RL1 RBP4 CD40LG MMP9 hEMMPRIN TFF3 PECAM1 SPP1 FGF8A CHI3L1 ENG GDF15 GC DPP4 VCAM1 BDNF CCL17 PMC9460763__F5 Impaired autophagy with augmented apoptosis in a Th1/Th2-imbalanced placental micromilieu is associated with spontaneous preterm birth BAX ATG3 ATG5 PMC3625555__F3 Neuroactive ligand-receptor interaction and calcium signaling pathway LPA PLN PTGDR CAV2 EZR TRH BCR MCU PMC8666534__F5 Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer FGF7 KLF2 EZH2 PTEN PMC6932950__F1 An overview of current and emerging agents for TNBC therapy BRCA1 DHFR PTCH1 SHH SMO MTOR CDK4 PMC7593950__F5 Simplified scheme of putative role, function, and involvement of VEGF, PlGF, and IGFBP-3 in signaling pathways described in angiogenesis and tumor growth CDC42 PLCG1 PIGF MTOR PMC9261367__F6 T-Cell Aging-Associated Phenotypes in Autoimmune Disease RAB5A RAB11A PMC7017752__F3 Emerging therapeutic targets for neurofibromatosis type 1 (NF1) CSF1 NF1 KIT CTNNB1 PMC10136628__F1 Metabolic pathway of tetrahydrobiopterin (BH4) TH DHFR PAH PMC7280434__F1 Current strategies to overcome multidrug resistance SHH SMO CTNNB1 PMC3834778__F4 Shear stress reveals the mechanisms by which OA induces PICs and MMPs in human chondrocytes FAS PLK3 TLR4 PLK1 PMC3834778__F5 Networks of shear stress-induced OA progression BAX IL1B PMC7017752__F2 Emerging therapeutic targets for neurofibromatosis type 1 (NF1) NF1 RIN1 GRB2 MTOR PMC2712453__F5 Erb-associated signaling pathways BAD BCR PC MTOR PMC8699595__F2 Abscission Checkpoint: A Guardian of Chromosomal Stability INCENP CHMP4C CHMP4B ATM CEP55 PMC2712453__F6 TLR-mediated innate immune signaling pathway CD80 SYK FAS TNFRSF1A TLR9 MYD88 IFNG IL1R1 TLR4 TLR8 TLR7 IL10 TLR5 IL10RA IL1A IL6 TNF TLR1 TLR3 IFNAR1 IL6ST JAK1 IFNB1 CD8A HLA-A TLR10 FADD LCK PMC6770077__F1 Pathway shows the influence of adipocytes on cancer IGF1 INSR COX2 ADIPOR1 ADIPOR2 LEPR IL6 MTOR IL6R IRS1 SLC31A1 PMC2712453__F7 Signaling pathway inferred from a gene regulatory network CDC42 RFWD2 BET1 FAR1 PMC8178558__F1 Innate type 1 immune response, but not IL-17 cells control tuberculosis infection TBK1 CGAS DDX41 IRF3 PMC2712453__F2 G1-phase signaling pathways inferred with different heuristics SWI5 CIB2 CDC20 PMC2712453__F3 S-phase signaling pathways inferred with different heuristics CDO1 FAR1 CDC45 CDC6 PMC10518420__F3 An emerging research: the role of hepatocellular carcinoma-derived exosomal circRNAs in the immune microenvironment IFNG PMC8253500__F4 Comprehensive Analysis of lncRNA and miRNA Regulatory Network Reveals Potential Prognostic Non-coding RNA Involved in Breast Cancer Progression COL4A3 SLC2A4 TCF7L1 PMC3234318__F1 OB inhibition by MM cells HGF CCL3 IL3 IL27 BMP2 IL7 PMC5531462__F6 Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer FGF9 EVI1 FGF2 PMC3882682__F8 Canonical pathways BLK SYK CD81 BTK BCL10 HEL-S-62p TLR4 CR2 CD180 CD19 RAC1 PMC5531462__F4 Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer c-fgr FGF9 EVI1 PLA2G4C GRB2 FGF2 PMC2706303__F2 Bioelectric mechanisms in regeneration: unique aspects and future perspectives PTEN SOX10 PMC7757044__F1 Roles of related miRNAs during the phases of autophagy ULK1 UVRAG MTOR STX17 VAMP8 VAMP7 ATG101 ATG10 LAMP2 ATG3 ATG12 AMBRA1 ATG5 SIRT1 ULK2 PMC4189469__F1 Schematic illustrating mechanism for expression and function of regulatory genes for development of the oviduct and for development of epithelial-derived ovarian cancer SERPINB3 TF SERPINB11 A2M SPP1 PMC3033586__F2 Wnt pathway and its regulation of Beta-catenin in stem cells and cancer CD44 APC GPR49 CCND1 CTNNB1 PMC7702481__F5 Dangers of déjà vu: memory B cells as the cells of origin of ABC-DLBCLs CD58 GC PC MB PMC9606746__F1 Terpenoid natural products exert neuroprotection via the PI3K/Akt pathway BAX COX2 GSK3B PTEN MTOR CTNNB1 PMC6736714__F8 Gli phosphorylation code SUFU SMO PMC10295080__F1 Nrf2 signalling pathway KEAP1 GCLM PMC8670931__F5 Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound NFE2 EMX2 EYA2 CDH11 MBP MAPKAPK2 HSPA2 ETV4 SDC1 PMC10244678__F9 Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway FGF8A NLRP3 WAPAL PMC4118478__F1 p53 at the crossroads of MPN treatment STAT1 STAT2 TPO MDM2 MTOR JAK1 TYK2 PMC7691375__F1 Comparison of mouse and human pro-resolving macrophages IL16 TLR4 TLR9 ARG1 IL1B PMC8928416__F4 NOD1 and NOD2 in inflammatory and infectious diseases RIPK2 MAVS ATG16L1 ATG12 NOD2 IRF3 IRF7 NOD1 TRAF3 HSPB8 ATG5 TRAF2 PMC11908617__F4 Effect of ZNFs on CRC metastasis‐related pathways [46, 47, 51, 52, 55] ZNF326 ZNF334 ZNF384 ZNF276 ZFP57 ZNF460 CTNNB1 PMC4072689__F5 Hijacking of Host Cellular Functions by an Intracellular Parasite, the Microsporidian Anncaliia algerae LIMA1 HINT1 EIF3S2 EIF3K STAT2 PXN MAP1B IRF9 IFIT1 IFIT3 IFIT2 IRF7 MX1 PMC5299128__F6 Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea ATOH1 PMC8838402__F10 Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2 ANXA2 PLG NOX4 PMC4127876__F1 Diagram depicting hypothetical mechanisms by which the polycystins directly affect gene transcription and regulate the cell cycle STAT1 ID2 CDK2 CTNNB1 PMC6681802__F1 Pharmacokinetic and pharmacodynamics pathways for mycophenolate mofetil UGT1A7 UGT1A9 CES2 UGT1A10 IMPDH1 CYP2C8 IMPDH2 UGT1A8 CYP3A4 UGT2B7 ABCC2 PMC8083963__F1 Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease WLS EGFR SNX3 SNX27 PMC8083963__F2 Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease VPS29 VPS35 F2 F3 PMC6987486__F2 Mechanisms of how Sfrps modulate cellular apoptosis, angiogenesis, differentiation, inflammatory process, and cardiac remodeling IL10 SFRP4 FAS BMP1 HGF WNT3A TNF CCND1 LEF1 CTNNB1 PMC4435778__F5 Meiotic recombination RAD51 SPO11 DMC1 PMC12005559__F2 Cholesterol metabolism and transport pathways LPL LDLR PMC12005559__F3 Anchor model of female steroidogenesis, describing the estradiol synthesis pathway, its regulation, and perturbation by dioxin CYP17A1 CYP11A1 HSD3B1 HSD17B1 PMC3463457__F1 Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells MAPK1 CDK6 CDKN1A FOXO1 CDKN1B PRB1 MTOR PMC3674226__F3 Where No Synapses Go: Gatekeepers of Circuit Remodeling and Synaptic Strength PTEN ARHA MTOR PMC5233484__F1 The canonical and non-canonical autophagy pathways ULK1 ATG5 PMC4557770__F1 B cell receptor (BCR) signaling pathway and molecular interactions in the CLL microenvironment CD40 SYK CXCL12 CCL3 MTOR BTK BCR CCR7 CXCR5 CCL4 LYN VCAM1 CXCR4 PMC8549879__F1 Hepatic LC3 II/I Ratio Is Not Modulated in Exercised Mice ATG3 ATG12 ATG14 BCL2 ATG5 PMC9189063__F3 IFNB basal expression through TLR4/TBK/IRF3 pathway TLR4 IRF3 PIGS PMC10949727__F3 FOXO3a regulating EMT and drug resistance in breast cancer BRD4 CDK6 MDM2 SKP2 SIRT6 PMC8185863__F2 Epithelial-mesenchymal transition-related circular RNAs in lung carcinoma AGO2 DKK1 SMAD2 APC SMAD4 UHRF1 CTNNB1 PMC6158482__F1 Neutralization of the interleukin-12/interleukin-23 pathways associated with T-cell activation and differentiation TH IL23R IL12RB1 PMC5358800__F1 Myelodysplastic syndromes: updates and nuances STAG2 TET2 BCOR ZRSR2 SF3B1 RUNX1 PRC1 ASXL1 EZH2 HEL-S-26 PMC11706994__F8 LCWE-induced ALI NLRP3 TLR4 IL6 MYD88 PMC11615488__F5 Map of phospho-proteins in cellular signaling pathways that regulate YPP expression in mosquito fat body RAB1A MTMR3 KIAA0226 ATXN1L UVRAG ZYX NUMB PTEN MTOR RHEB TSC2 RICTOR ATG3 TSC1 ATG12 BCL2 SCRIB PMC4214761__F5 Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma TFRC CD74 PI3 CTSK MIF PMC7700615__F2 Signaling via TGFB receptors initiated at different intracellular locations and sites of inhibition by RAC1B TF SMURF1 SMAD2 SMAD4 SMURF2 SRC PMC4158461__F7 The underlying mechanism of CFE on the TLR4 signaling pathway IL16 TLR4 IL1B MYD88 PMC9420733__F6 Signaling pathways in obesity: mechanisms and therapeutic interventions CCK PYY POMC MC4R MC3R MC2R NPY ARC AgRP PMC3142564__F3A Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer EGFR ERBB2 MTOR PMC9420733__F2 Signaling pathways in obesity: mechanisms and therapeutic interventions IGF1 POMC UCP1 BMP7 NPY PTEN AgRP PZP Nucb2 IRS1 PMC9420733__F3 Signaling pathways in obesity: mechanisms and therapeutic interventions ADRB3 GDF3 ALK GDF15 POMC UCP1 NPY GFRAL AgRP RET pp6425 PMC9420733__F4 Signaling pathways in obesity: mechanisms and therapeutic interventions STAT3 OSBPL2 CXXC5 ADD1 NOTUM LRP5 UCP1 LRP6 RYK ARHA CTNNB1 PMC8145522__F2 Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN TBK1 CGAS MAVS USP15 TRIM25 RBM10 IRF3 IRF7 ATF2 PMC9420733__F5 Signaling pathways in obesity: mechanisms and therapeutic interventions BMP4 FASN POMC UCP1 FABP4 NPY AgRP PMC10949727__F2 FOXO3a regulating apoptosis and cell cycle in breast cancer BAX CASP9 FAS CASP3 CCND1 PMC8996682__F6 Blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments BAX NLRP3 CX3CR1 TLR4 CCR6 CX3CL1 NGB VCAM1 CD163 CTNNB1 MYD88 PMC6260991__F7 Schematic representation for hypothetical M2 macrophage-induced myofibroblast differentiation of LR-MSCs WNT7A FZD1 CTNNB1 PMC8469180__F3 Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Glucose Homeostasis and Diabetes-Related Endothelial Cell Dysfunction GRB2 IRS1 PMC3813872__F7 Models of Eph signaling in amphid axon guidance SGK1 PTEN PMC5629631__F23 Multiple modes of AOAA’s action in cancer cells GOT2 PMC2872012__F4 Functional genetic network as defined by the bioPIXIE tool (Myers et al VPS29 SAP30 VPS18 RIC1 VPS72 LEO1 RTF1 VPS36 PMC7883806__F1 Wnt signaling pathway ROR1 APC ROR2 GSK3B LRP5 LRP6 ARHA RAC1 DAAM1 CTNNB1 PMC2872012__F5 Detailed representation of the interactions between the components of the gene network VPS29 VPS35 VPS72 PMC6125421__F2 Signaling pathways of the unfolded protein response ATF4 EIF2A XBP1 PMC8023019__F1 Rationale for the combined use of an ICD inducer and an IDO-1 inhibitor HMGB1 APC ELF2 AHR MTOR PMC3434988__F1 Hepatocyte growth factor (HGF)–cMET axis signaling network and ongoing targeted therapy strategies RPTOR HGF EGFR GAR1 PMC7925880__F6 LREE regulates bile acid metabolism through intestinal flora NR2A1 FGFR4 LDLR PMC7734567__F2 Mapping the 12 pairs of genes, which are positively correlated in all 12 types of cancer, into the tryptophan metabolic pathway GCDH EHHADH AOX1 INMT DHTKD1 ACAT2 DLD PMC6374451__F7 Schematic overview of DNA demethylation during glioma progression PIK3CA CDKN2A CCNE1 IGF2BP3 PI3 PIK3R1 CDK4 PMC2998559__F1 Model Depicting major molecules and events in mast cell activation SYK BTK ORAI1 LAT STIM1 LYN GRB2 GAB2 PMC6779289__F2 PPI network generated for the proteins encoded by the eight statistical driver genes SYK ATR EGFR FABP1 BRCA2 CD46 BLM LIPC TEC BTK CFI PLCG2 NCOR1 ITK RAD50 LCP2 CFD DLL4 CFH KLRK1 BLNK MICA CD55 NCOA1 RBPJ MED1 RPA1 XRCC3 RAD51B NCOR2 RAD51C ITGAM CFHR3 RAD1 POLK PSEN2 APOB LYN PMC3626710__F5 Results from single pathway sets PCM1 PGM3 PGM2 HEL-S-49 FBP1 BST1 ARG1 ARG2 PMC6889286__F2 Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer STAT3 ROS1 ALK AXL EGFR NTRK1 BRAF FGFR3 PTEN MTOR RET PMC6628002__F2 Schematic representation of physiological and pathological aspects (major sources of oxidative stress) in Alzheimer’s disease (AD) and their corresponding antioxidant defense approach by anthocyanin in cholinergic neurons BAX GFAP CASP3 APP PMC7884371__F2 The NLRP3 inflammasome pathway GSDMD NLRP3 NOD2 RIPK1 TNF IL1B FADD MYD88 PMC7929492__F1 Canonical activation pathway for the NLRP3 inflammasome NLRP3 TLR4 RELA IL1B MYD88 PMC5775519__F1 Pattern recognition receptors (PRRs) for human immunodeficiency virus type 1 (HIV-1) recognition and the following pathway for triggering type I interferon (IFN-I) expression CGAS IFI16 IRF3 IRF7 MYD88 PMC8568271__F5 Interleukin-1 activation of NF-kB through Ajuba AJUBA TRAF6 CYLD PMC11125956__F11 Osteoblasts in Rheumatoid Arthritis Pathway BGLAP DVL1 SMAD9 SMAD1 ALPL CSF1 DKFZp781O1323 TGFB1 WNT3A GSK3B SMAD4 APC2 RUNX2 COL1A1 IL11 CSNK1A1 DKK2 SRC BMPR2 APC SMAD6 SP7 IL6 TNF SPP1 SMURF1 IGF1 AXIN1 BMP2 BCL2 PTH DLX5 TNFRSF11B WIF1 PMC5775519__F2 Type I interferons (IFN-I)-initiated signaling pathway leading to interferon-stimulated gene (ISG) expression STAT1 STAT2 IRF9 PMC9099669__F2 Demystifying the Neuroprotective Role of Neuropeptides in Parkinson’s Disease: A Newfangled and Eloquent Therapeutic Perspective HTRA2 VPS35 PINK1 SYNJ1 LRRK2 SNCA HEL-117 PMC11125956__F13 B Cell Receptor Signaling Pathway, KEGG SYK CD81 CD72 RASGRP3 BANK1 CD22 BLNK CD19 BLK BTK BCL10 BCR GC LYN GRB2 PMC11854592__F2 The EpCAM signaling pathway in cancer progression EPCAM ADAM17 EGFR FHL2 LEF1 CTNNB1 PMC3429092__F4 TRPC5-mediated feedback of Ca2+ and NO signaling in endothelial cells and attenuation of Ca2+ entry through TRPC6 by NO in smooth muscle cells TRPC5 HEL-S-11 TRPC6 PMC9099669__F5 Demystifying the Neuroprotective Role of Neuropeptides in Parkinson’s Disease: A Newfangled and Eloquent Therapeutic Perspective BAX TNF PMC7463463__F1 Amino acid metabolic pathways altered in cancer and select inhibitors targeting these pathways CDC42 ID2 PAK1 AHR AFMID RAC1 PMC7463463__F2 Targetable vulnerabilities related to serine and 1C metabolism PHGDH DHFR SHMT1 HEL-S-51e DHODH PMC7439204__F5 Anti-ARDS pathway of YQHYJD in KEGG EGF JUN BAD TGFA NRG3 MTOR SHE MYC NRG4 NRG2 CBL GRB2 SRC PMC10975212__F1 TGFB/SMAD signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC3462343__F7 Model depicting how chronic exposure to SAg could elicit an autoimmune disease SAG BCR APC PMC2785474__F4 TLR4 and chemokine receptor cross-talk ADRBK1 TLR4 IL8RB PMC11987241__F8 M2Φ-exos-mediated TGFB1-induced phenotypic transformation in BEAS-2B cells SMAD2 SMAD4 PMC10975212__F5 Non-SMAD, non-canonical TGFB pathways CDC42 TF TRAF4 SMAD6 ARHA MTOR SMURF2 TRAF6 RAC1 PMC2785474__F2 TLR signaling (an example in macrophages and dendritic cells) TBK1 TIRAP TLR9 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR7 PMC10525362__F1 Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond VIT CYP27B1 DBP CYP27A1 PMC3255783__F7 Model depicting the potential roles of Hrq1 in NER-based lesion processing XPA REV1 PCNA PMC11089204__F5 Proposed metabolic pathway of psilocybin and its active metabolite psilocin UGT1A9 UGT1A10 PMC4591813__F5 ErbB3 in RAF-inhibited mutant BRAF melanoma cells ERBB3 NRG1 ERBB2 PMC10670187__F1 LncRNA MIR4435-2HG is involved in signaling pathways for cancer progression CDH2 CDCA5 SNAI1 IQGAP3 SMAD2 MMP9 MTOR CTNNB1 PMC3121749__F8 Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions JUN LEFTY1 SMAD2 CRIPTO SMAD6 LEFTY2 CER1 SMAD4 NODAL SKI FOS PMC4863644__F2 Glucose stimulated insulin secretion (GSIS) and suggested stimulus/secretion coupling factors CIC PC GIP PMC7128029__F1 BA synthesis and transport pathway ATP8B1 FGF8A CYP7A1 PC PMC2943748__F6 SENP1 participates in the dynamic regulation of Elk-1 SUMOylation SENP1 HDAC2 FOS PMC10217757__F1 Specific Features of Focal Cortical Dysplasia in Tuberous Sclerosis Complex RHEB RPTOR TSC2 TSC1 TBC1D7 AKT1S1 MTOR DEPTOR PMC2759942__F5 Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity BMP4 BMP2 PMC7466447__F1 Immunoregulatory functions of TEC in the TME TEC IFNG CGAS EGFL7 CXCL10 FGF2 PMC7281325__F3 Multi-omic study identified up- and downregulated candidates in acquired trastuzumab-resistant BT-474.r2T cells compared to parental sensitive BT-474 cells ASS1 BAD HEY2 PXN IFIT3 MARCKS IFIT2 NEK9 FLNA TEAD2 AHNAK PSCA OAS2 IKZF3 ARHGAP35 CTIF SMARCC1 IFNL2 HIRIP3 TCOF1 VSIG2 NIPAL3 MAP4 MISP IMUP SPTBN1 ARFGEF2 DUT KRT4 CXCL10 MED1 MUC19 SET COG3 EMP1 CXCL11 PPFIBP2 BPIFB1 VAPB PCM1 TCEA3 DBN1 PLEC RS1 MCM2 PMC5259880__F3 The molecular mechanisms dysregulated in PD and thought to lead to DAergic neuronal cell death HTRA2 LRRK2 PLA2G6 FBXO7 SNCA PMC9221436__F4 Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment BMI1 KLF4 CD44 SOX2 PTEN MTOR TWIST1 CTNNB1 PMC6040288__F9 Network pathway: pathway enrichment analysis was performed LPL RTN4 APOE FES APP TNF FADD PMC10945329__F9 ADSCs-Exo pathway reduces pyroptosis and improves tissue regeneration in the liver, which has been injured by ischemia-reperfusion and partial resection GSDMD NLRP3 TLR4 CCND1 CTNNB1 PMC3047798__F3 Wnt signaling components regulate ubiquitylation SIAH1 APC CTNNB1 PMC3187166__F1 Selected part of the central metabolism in C HEL-S-162eP PTS ENO1 CS PMC5491788__F9 Intestinal FXR and TGR5 cross-talk in the regulation of GLP-1 secretion, hepatic bile aid synthesis, glucose and lipid metabolism, and insulin and glucose sensitivity CYP8B1 CYP7A1 FGFR4 CYP7B1 CYP27A1 PMC5615985__F6 Role of the LGM2605 in preventing asbestos-induced inflammation, oxidative/nitrosative cell damage, cell injury, and cell death proposed mechanism of asbestos-induced inflammation and oxidative/nitrosative stress and the protective effect of LGM2605 HMGB1 NLRP3 IL16 IL6 TNF PMC3047798__F1 Ubiquitin-mediated regulation of the core Wnt pathway components APC, Axin and Beta-catenin SIAH1 USP15 TNKS APC LRP5 LRP6 CTNNB1 PMC3142070__F4 Cause and metabolic consequences of fatty liver NR1C1 SHBG DGAT2 APOB ELOVL6 PMC4718179__F4 Activation of EGC and induction of a reactive EGC phenotype CD80 NR1C1 GFAP GDNF SOX9 SOX10 SOX8 S100B PMC8303222__F2 Importance of Being PI3K in the RAS Signaling Network BTK PTEN GRB2 CTNNB1 PMC6247401__F6 Proposed role of macrophage LRP1 depicted in diet-induced inflammatory conditions SFRP5 TH APC LRP5 LRP6 CTNNB1 PMC4897783__F8 Glucose induced activation of canonical Wnt signaling pathway in hepatocellular carcinoma is regulated by DKK4 DKK4 LRP5 CTNNB1 PMC2692402__F1 Glycerol phosphate pathway for de novo triacylglycerol (TAG) and glycerophospholipid synthesis LPA AGPAT5 HMFN0839 DGAT1 GPAT4 GPAT2 DGAT2 AGPAT3 AGPAT4 PC PMC5665759__F3 Androgen‐regulated lncRNAs, SOCS2‐AS1 and POTEF‐AS1 promote prostate cancer growth TLR3 POTEF SOCS2 TNFSF10 PMC4320821__F4 Network graph showing interactions between ID2 and ID3 and their MIC-inferred ‘target’ genes regulating cell death MAX KLF4 DUSP10 HEL113 TRADD CYCS PIK3R1 CREM PPP2CA ATF2 YY1 MYC ITGAX DUSP2 PRKCH DUSP3 IGF2R TXN GZMH SUMO3 NFE2 SUMO2 CCND1 MAP2K3 THBS1 JUN SIAH1 SP1 ID2 PTGS2 FOS ID3 RELA CREBBP BCL2 PMC3088996__F3 Regulatory role of ATM in cellular responses to DNA DSB repair FANCD2 RAD50 MRE11A BRCA1 CDK2 ATM MDM2 MDC1 PMC4184842__F6 Gene Expression Response of Chronic Lymphocytic Leukemia Cells to IL-4 Is Specific, Depends on ZAP-70 Status and Is Differentially Affected by an NFKB Inhibitor SOCS1 HRAS ZAP70 JAK3 NFKBIA GRB2 JAK1 IRS1 PMC8927800__F3 Type 2 Diabetes Complicated With Heart Failure: Research on Therapeutic Mechanism and Potential Drug Development Based on Insulin Signaling Pathway CD96 CASP9 BAD IGF1 MTOR PMC5795460__F1 Only the classical role of the Fanconi anemia (FA) pathway in the repair of interstrand cross-links (ICLs) is depicted, which involves highly coordinated protein–DNA and protein–protein interactions in the nucleus FANCE FANCD2 FANCG ATR FANCF ATM FANCM FANCL FANCA FANCC FANCB PMC5770079__F6 Apoptosis signaling pathway BAX CASP9 FAS CASP8 TRADD EIF2S1 CASP6 CASP3 DDIT3 BCL2 ATF4 MDM2 APAF1 TRAF2 FADD PMC8641876__F1 Schematic depiction of the regulatory network of YAP/TAZ LATS1 LATS2 SIRT1 PMC8927800__F1 Type 2 Diabetes Complicated With Heart Failure: Research on Therapeutic Mechanism and Potential Drug Development Based on Insulin Signaling Pathway IGF1 MTOR IRS1 PMC6635453__F5 Proposed pathway for RQ biosynthesis in C COQ3 COQ2 COQ6 COQ5 PMC6966492__F1 Cell death pathways triggered by the temozolomide-induced DNA lesion O6-methylguanine BAX ATR FAS SIAH1 HIPK2 ATM MGMT PMC8888891__F2 Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity? JUN SMURF1 SOX9 ADIPOR1 NFATC1 MTOR SMURF2 TRAF6 RUNX2 XBP1 TRAF2 CTNNB1 PMC7294112__F7 Schematic to represent the proposed molecular events in DHL‐induced apoptosis in laryngeal carcinoma cells BAX BAD PTEN PMC2919149__F7 Targeting HIF activation pathway for cancer therapy UQCRB HEL-S-11 MTOR VHL PMC10028837__F1 The oxidative phase of the pentose phosphate pathway including 6-phosphogluconolactonase (Pgl), that converts 6-P-gluconololactone to gluconate-6-P PURA TH LTA HAL PURB FOS PMC7052781__F2 Metabolic coordination of macrophage activation IFNG CD36 TLR4 PMC5482192__F5 Ten differentially expressed genes between human bizarre parosteal osteochondromatous proliferation and osteochondroma enriched in the TGFB signaling pathway SMAD1 THBS1 SP1 SMAD2 SMAD6 SMAD4 NODAL ARHA TGFBR1 BAMBI IFNG RBX1 SMURF1 E2F4 FST ROCK1 CTBP1 SKP1 SMURF2 PMC7332497__F3 Cytosolic and sub-cellular engineering of yeast for isoprenoids biosynthesis IPP IDI1 ADA PMC3659771__F1 Notch signaling in the vasculature MAML1 DLL4 JAG2 LFNG MFNG NOTCH2 NOTCH3 DLL3 RBPJ NOTCH1 PMC7952454__F3 DNASE2A deficiency causes an accumulation of phagocytosed dsDNA as well as nuclear dsDNA transported by autophagy into endolysosomal compartments IFNG CGAS TLR9 AIM2 IRF3 TLR7 PLD4 IL1B MYD88 PLD3 PMC3659771__F2 Notch signaling in the vasculature EPHB4 FOXC2 FOXC1 VEGFA NOTCH1 PMC6186458__F1 BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis BAX FADD PMC9686795__F1 Link between Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation in the Pathophysiology of Alzheimer’s Disease: Therapeutic Implications and Future Perspectives ATG101 NBR1 PINK1 FIS1 LRRK2 ULK1 AMBRA1 ATG14 PMC5705532__F1 Signaling involving TLR2 and TLR4 in strenuous and moderate aerobic exercise STAT3 IL10 TLR4 MTOR PMC2360544__F2 Novel therapeutic targets and proposed mechanisms of androgen resistance (text in red) in hormone refractory prostate cancer TMPRSS2 ADAR MTOR PMC9478452__F1 Current perspectives on interethnic variability in multiple myeloma: Single cell technology, population pharmacogenetics and molecular signal transduction CD40 STAT3 MLN LTBR LIF RELB APC IGF1R TRAF3 TNF MYC DEPTOR CTNNB1 TSC2 RICTOR TSC1 IGF1 COX2 CDK2 GRB2 TRAF2 CYLD CCND1 PMC6205911__F1 Post-squalene cholesterol biosynthetic pathway and examples of malformation disorders associated with defects at specific steps CYP51A1 EBP DHCR24 DHCR7 PMC4064721__F1 Scheme of participation of MC1R in regulation of melanogenesis ADRBK1 MRAP MC1R MGRN1 ASIP ARRB2 PMC4765532__F2 BMP signaling pathway including microRNA regulation SMAD1 DKFZp781O1323 BMP2 SMAD6 SMAD4 PMC4064721__F2 Scheme of the impact of MC1R on development of melanoma MC1R BRAF NRAS SRC SDC2 PMC4765532__F3 Wnt signaling pathway including microRNA regulation LRP4 SOST COL1A1 APC LRP5 LRP6 COL3A1 CTNNB1 PMC8648396__F10 Matrix metalloproteinases and tissue inhibitors of metalloproteinases in murine Beta-coronavirus-induced neuroinflammation HMOX1 TIMP1 HEL-S-67p RELA PMC8395092__F2 Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes CD80 BCR APC PMC4986885__F3 SRSF1's roles in transformation in breast cancer RRM1 RRM2 BIN1 MYC PMC5620176__F9 LncRNA ANCR down-regulation promotes TGF-Beta-induced EMT and metastasis in breast cancer HDAC3 RUNX2 PMC3840000__F1 A Potential Benefit of Albinism in Astyanax Cavefish: Downregulation of the oca2 Gene Increases Tyrosine and Catecholamine Levels as an Alternative to Melanin Synthesis DCT TYRP1 SLC24A5 PMC8597301__F8 Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis TLR4 MYD88 PMC6320319__F1 Schematic summary of the Wnt signaling derangements and the different traits of metabolic syndrome TG TCF7L2 ROCK2 SP1 LRP6 ARHA HEL-S-70p PMC5986049__F1 Control of erythropoietin (EPO) synthesis by the oxygen sensing pathway EPO VHL PMC4797366__F3 Wnt signalling in energy balance regulation LEPR GSK3B LRP6 AXIN2 PMC7122459__F1 Molecular signaling pathways involved in astrocytogenesis CNTF SOX9 LIF BMP2 NFIA PMC3430392__F1 The function of CETP in RCT.Notes: CETP mediates the equimolar transfer of CE and TG between atherogenic VLDL, LDL, and anti-atherogenic HDL LPL TG PMC7369697__F1 BRAF signaling pathway including abnormal signaling from BRAFV600E mutated proteins ARAF BAD BRAF PMC11134594__F2 TGFB signaling pathway: Integrins release TGFB by binding to LLC on ECM SMAD2 SMAD4 PMC7065707__F4 Cell cycle in stem cell proliferation, pluripotency and differentiation RBL1 CCNE2 SOX2 CCND1 HES1 PMC7065707__F2 Cell cycle in stem cell proliferation, pluripotency and differentiation CDC2 RB1 SOX2 CDK2 PMC3281554__F2 Possible mechanisms of regulation of DP thymocytes by multiple factors RORC ID3 CTNNB1 PMC11892258__F3 Mechanism of immunosenescence promoting tumor occurrence and development TREM2 SYK CXCR1 NAMPT SIRT1 PMC5192802__F2 Roles of nucleus PRDX1 in the H2O2‐induced apoptosis BAX PMC6928143__F5 Wnt signaling pathway was involved in NFPA CDC42 NPPA APC HEL-S-11 ATF2 ARHA CTNNB1 PMC6928143__F6 ERK-MAPK signaling pathway was involved in NFPA CRK BAD MOS PXN GRB2 SRC MYC EIF4E PMC3590201__F1 Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations MAX ECSIT EGF JUN CYC1 ATF2 TNF DAO FLNA MEF2C NFIB NLK BDNF PMC4097957__F1 TLR4 signaling pathway TBK1 TLR3 TLR4 TAB3 MAL IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC4770718__F1 PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response HEL-S-31 MAPK1 TBK1 ARRB2 STAT2 MAPKAPK2 CD14 HEL-S-28 IRF3 IRF8 TNF TRAF6 KRAS MYD88 MAPK3 STAT1 NFKB1 NFAT5 IKBKB TAOK3 MAP2K1 MAP2K2 MAP2K3 PMC9130030__F1 Realigning the LIGHT signaling network to control dysregulated inflammation LTBR CD160 BTLA PMC6928143__F3 PI3K-AKT signaling pathway was involved in NFPA RHEB TSC2 BAD HEL-S-69p HEL-S-28 PTEN CDC37 GRB2 MTOR EIF4E PMC4146642__F7 ABeta(1-42) oligomer-induced oxidative stress PIN1 CA9 PMC7692354__F1 Near-infrared (NIR)-triggered photothermal action in MDA-MB-231 and MCF7 cell lines: the illustration shows irinotecan hydrochloride (IT) on-demand release from irinotecan-loaded biotinylated carbon nanodots (CDs-PEG-BT/IT) by means of hyperthermia TRADD MLKL TRAF3 RIPK3 TRAF4 ATG3 TRAF5 RIPK1 ATG5 APAF1 TRAF2 CYLD FADD PMC6928143__F4 mTOR signaling pathway was involved in NFPA RHEB RPS6 EIF4B RICTOR HEL-S-69p RHO ERG PMC8151911__F2 Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review STAT3 GEM GC TRAF6 PMC11056900__F1 Molecular mechanism of mitochondrial dysfunction modulating the relationship between chronic liver disease SIRT3 STAT1 CGAS NLRP3 BNIP3 MCU IRF3 PMC11056900__F2 Endoplasmic reticulum dysfunction modulates chronic liver disease ATF4 EIF2A XBP1 IL1B PMC11056900__F3 Mitochondrial and endoplasmic reticulum-associated signaling regulates the molecular mechanism of chronic liver disease ROS1 MFN1 MFN2 PMC6169299__F8 Signalling pathways in the TLR response CD40 CXCL9 CD80 TBK1 CCL3 CD14 IRAK1 IRF3 IRF7 TRAF3 CCL5 CXCL10 MYD88 TLR3 TLR4 TLR8 CCL4 TLR7 PMC7990044__F3 Genetic modifications designed to address xenograft injury mechanisms GAL HLA-E APC SIRPA CD47 PMC8549681__F1 Glucocorticoids induce osteonecrosis of the femoral head through the Hippo signaling pathway LATS1 LATS2 RUNX2 PMC8389838__F5 Targeting Small GTPases and Their Prenylation in Diabetes Mellitus CDC42 RALA PAK1 ARHA TBC1D4 RAC1 IRS1 PMC7210546__F4 Possible cross-regulation of RAS and TLR4 in mediating the inflammation of DN TLR4 MYD88 PMC7210546__F1 TLRs and signaling molecules on the basis of literatures TIRAP TLR4 TLR9 TLR8 TLR5 IRF3 TLR7 TRAF6 MYD88 PMC7210546__F2 TLR4 signaling pathway in the DN on the basis of literatures TIRAP TLR4 IRF3 TRAF6 MYD88 PMC4323418__F7 Map of central carbon metabolism highlighting CceR and AkgR targets MAL TNLG7C CIT PMC5481839__F6 DOT1L safeguards cartilage homeostasis and protects against osteoarthritis DOT1L PPARGC1A LEF1 SIRT1 PMC7073516__F2 Fast and slow routes to break-induced telomere synthesis POLD3 RFC4 RFC1 RAD51 RFC2 MND1 PCNA RFC3 PMC10605176__F3 Noble gas-induced neuroprotection BAX TLR4 HEL-S-44 PMC6536925__F6 Relationship of the three diseases at gene, pathway, module, and function levels and the biological mechanism of T2DM, CML, and PCa SGCD PC MTOR PMC8087798__F8 Mechanism of POU2F2 regulates glycolytic reprogramming and GBM progression POU2F2 PDPK1 HK2 MTOR PMC10605176__F1 Neuroprotection by the volatile anesthetics sevoflurane and isoflurane STAT3 SP1 TLR4 GSK3B PMC6775191__F8 Network visualization analysis of “potential lipid markers-lipoproteins-TLR4/MyD88 signaling pathways” for anti-inflammatory effects of HLJDD CD36 SGMS1 KLRB1 SPHK1 PLA2G1B PLA2G3 SGMS2 PLA2G5 SMPD1 PLA2G2F SMPD2 PLA2G12B PLA2G2A MYD88 B3GAT1 PLA2G10 APOA5 IL1B CERK APOE HEL-S-34 PLA2G6 PEMT LIPE APOB PIGS PLA2G4B PMC7944035__F1 TLRs multiple signaling pathways STAT3 CD24 SMAD1 NLRP3 IGF1 TLR4 SMAD2 IRF3 MYD88 PMC4214202__F1 Simplified model of the potential contributions of selective sensors and cell types to IFN production during viral infections TBK1 CGAS TANK TLR9 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 XCR1 TLR3 PDC TLR8 TLR7 PMC11983764__F1 BCAA metabolism and tumours BCKDK PPM1K SLC25A44 GPRC5C BCAT2 BCAT1 PMC11983764__F2 BCAA hypocatabolism promotes tumour development ACLY BCKDK RAB1A CDC20 SLC25A44 BCAT2 RNF167 MEIS1 BCAT1 EZH2 STAMBPL1 PMC3249369__F4 Three MAPK pathways in yeast share common components and also contain pathway-specific factors CDC42 TXN RHO PMC5428537__F1 Meta Core pathway analysis indicated that cardiac hypertrophy signaling was significantly associated with sesamin-treated samples (P=1.148E-10) GAA APC HAND1 GATA4 TRPC3 HAND2 MEF2C PMC5514220__F2 Involvement of sirtuins in lifespan/healthspan elongation pathways IGF1 NAMPT MTOR PMC4019040__F1 Mutated and wild-type tyrosine kinase activation in cancer SYK BTK BCR EGFR FGFR1 ERBB2 LYN FGF2 PMC4093113__F2 Pathway analysis of the candidate genes NR1C1 F2 APOB KIN PMC2685579__F1 Synthetic pathways for polar lipids PGP PSD PC PMC9217774__F3 Serial Tumor Molecular Profiling of Newly Diagnosed HER2-Negative Breast Cancers During Chemotherapy in Combination with Angiogenesis Inhibitors ARAF ATR KIT KRAS RET PMC11084561__F3 Two consecutive signals are requisite for inflammasome activation GSDMD NLRP3 AIM2 PMC4394821__F1 Folate biosynthesis and utilization pathway (modified from reference ) DHFR FPGS DHPS PMC8261820__F3 Signal pathways and treatment of cytokine storm in COVID-19 MAVS STAT2 IRF9 IRF3 IRF7 MYD88 STAT1 TLR3 TLR8 TLR7 JAK1 TYK2 ACE2 PMC3883350__F1 VIP tunes immune and inflammatory response by regulating multiple signaling pathways VIP CD40 IL10 JUN RAF1 JUNB IRF1 CTLA4 TNF IFNG STAT1 COX2 TLR4 IL2 FOXP3 JAK1 TBP PMC4963239__F4 Mediator complex: a central integrator of transcription MED23 MED12 MED15 MED17 IRF7 TRAF3 CTNNB1 MYD88 PMC3834244__F1 MiRNA biogenesis and function AGO4 DGCR8 AGO1 AGO2 DICER1 DROSHA PMC3652852__F7 Peroxisome Proliferator-Activated Receptor (PPAR) G and PPARA Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders? NR1C1 APC PMC12148668__S1 Schematic diagram illustrates the preparation of IFNG treated RAW 264 NHS GC IL1B PMC3623586__F2 Schematic model of the regulation of intestinal homeostasis by the IL-22/STAT3 pathway in IECs STAT3 IF2B1 TYK2 PMC9187046__F1 GSK-3 regulates PD-1 and LAG3 expression for enhanced T-cell reactivity CD80 LAG3 LCK CTNNB1 PMC8593497__F1 Metformin on Hepatic Steatosis in Adults with Nonalcoholic Fatty Liver Disease and Diabetes: Insights from the Cellular to Patient Levels SCD ROCK1 LEPR HEL-S-5 TNF SIRT1 PMC7291227__F4 Ingenuity Pathway Analysis (IPA) upstream regulatory analysis TRIM31 TBX1 TLE4 CTSK KLK3 HCGV TERT TBX5 ASCL2 GJB1 MYC GCHFR COL2A1 NKX3-1 HDAC1 SOX9 MCM3 PMC7291227__F3 Ingenuity Pathway Analysis (IPA) gene network analysis MCAT NAALADL2 Pax9 TCP1 RPL22L1 NOL10 VGLL3 MYC SOX9 WTAP TMPRSS2 JAZF1 KLK3 GCHFR CAT56 RPL3 DIS3L LOXL2 MRM3 PSMD5 RSBN1L RUVBL1 KLNA1 HOXA4 TFEB TRIM8 ZGPAT USP20 ASNS TIMM23 RPS9 HAUS6 MYO9B TOR1B PMC5533267__F6 Glabridin on the estrogen pathway SP1 IGF1 PGR PMC4414696__F3 Simplified TAM signaling pathways in supporting cell proliferation and survival (A) and inhibiting inflammation (B) SOCS1 SOCS3 GRB2 PMC3866828__F3 HVJ-E-mediated apoptosis pathway in cancer cells CASP9 CASP8 MAVS CASP3 IRF3 IRF7 PMC4612381__F6 Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging EDEM1 HEL-S-269 ATF4 IL6 EIF2A XBP1 PMC5711482__F1 Targeting polyamine metabolism for cancer therapy and prevention SMOX PAOX PMC8295747__F2 Harnessing the Activation of RIG-I Like Receptors to Inhibit Glioblastoma Tumorigenesis TBK1 MAVS CASP3 IRF1 IRF3 IRF7 PMC8589328__F1 Substrate, intermediates and enzymes involved in the endogenous production and disposal of H2S VIT ETHE1 HEL-S-61p SUOX PMC10531041__F2 Stress Response in Autophagy Processes and Aging-Related Diseases BAG3 HSPB8 HEL-S-100n PMC11584093__F4 Anti-cancer signalling pathways modulated by curcumin, gingerol, and shogaol in cervical cancer cells BAX EGFR CTNNB1 PMC7810546__F7 Compound-target-pathway network CXCR3 HEL107 PPARG SYK ALPL MMP12 IKBKE BRAF F7 PRKCZ TERT PPP3CA VCP NCF1 MPO PRKCH HTR2B MYLK ALDH2 OLR1 PIG59 PRKCE F2R F2 NR3A2 PDE3A ACKR3 MMP3 APP HEL-S-11 KDR MDM2 SRC TOP2A EPHX2 NR1i1 BAX NOS2 JUN SELE KIT PTGS2 TNF FGF2 BCL2 EP300 PMC9272595__F8 Oncogenic receptor tyrosine kinase pathway with its downstream signaling pathways and small molecule inhibitors targeting different proteins of the network ROS1 AXL EGFR GRB2 MTOR PMC11899589__F7 Schematic representation illustrating the mechanism of action of erianin in lung cancer CAD MTOR DHODH PMC4825669__F6A Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy MYL7 STAT3 ZSCAN20 FRZB GNAO1 UBC GNB3 LY6G5B MYH4 FOS GPD1 MEF2C DKK3 RAZ1 BUD31 WNT9A VASN CEBPB RCAN1 MYH2 PMC8949908__F5 Betaine Supplementation Causes an Increase in Fatty Acid Oxidation and Carbohydrate Metabolism in Livers of Mice Fed a High-Fat Diet: A Proteomic Analysis HEL-S-22 CNPY2 ACADM BAAT SERPINC1 ACOX1 LGALS3BP NHP2 TIMM13 CHD6 EEF1B2 PCBP1 HMGN1 PC4 CASP8AP2 NOP58 CHCHD3 APOA2 RPE HOGA1 AGMAT UROC1 GSTM1 HYOU1 HEL-S-162eP PMC10139027__F5 Scheme of LDLR activity signaling pathway for follicular development with lovastatin stimulates steroidogenesis in ovaries STAR LDLR FSHR PMC8362328__F10 Upregulation of KLK8 Predicts Poor Prognosis in Pancreatic Cancer EGF KLK8 EGFR MTOR PMC8268639__F1 NUAK1 and NUAK2 Fine-Tune TGFB Signaling NUAK1 SMAD2 SMAD4 PMC7295848__F1 PI3K/AKT signaling cascades in cancers PIK3CA GC PC PTEN MYC PMC8133338__F1 Erythropoietin in bone homeostasis—Implications for efficacious anemia therapy EPO CD19 PMC5732365__F1 Rho GTPases and AD pathology APP ARHA RHO RAC1 PMC1878539__F1 Unchecked thrombin is bad news for troubled arteries TF TFPI APC PMC6172470__F1 Translation acrobatics: how cancer cells exploit alternate modes of translational initiation EIF4B ELF1 SUI1 EIF2A ELF3 PMC8219921__F1 Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System PTBP1 EGFR APC SOX2 ZEB2 CCND1 CTNNB1 PMC3674397__F2 Mechanisms of activity for sirtuins in Alzheimer's disease RARB ROCK1 APP ADAM10 PMC12155304__F4 Sinhyotaklisan as a Potential Therapeutic for Psoriasis: Network Pharmacology and Experimental Validation STAT3 PPARG EGF TGFB1 EGFR HIF1A MYC CCL2 MAPK3 CTNNB1 ALB HMOX1 IFNG CCND1 IL1B JUN HEL-S-89n PTGS2 MMP9 IL1A IL6 TNF FOS NR1C1 RELA CASP3 NFE2L2 ERBB2 BCL2 PMC6193563__F3 Metabolic reprogramming of the tumor microenvironment by p62 and its partners NR1i1 NBR1 KEAP1 TRAF6 PMC9061988__F1 Mathematical Modeling of Complement Pathway Dynamics for Target Validation and Selection of Drug Modalities for Complement Therapies C6 CD59 FH C9 CS PMC8888691__F5 Microglia and Astrocyte Function and Communication: What Do We Know in Humans? CCL3 CCR5 CCR2 TLR9 TLR5 CCR3 CCL5 CCL2 TLR1 TLR3 IL16 TLR4 TLR8 CCR4 CCL4 TLR7 CD200 CCR1 PMC8020258__F6 Osthole inhibits macrophage activation in an experimental model of asthma (schematic) IL4 ARG1 MIF PMC4964517__F4 Upregulation of melanogenesis by SOX9 SOX9 DCT PMC9495336__F3 Fucoidan from Marine Macroalgae: Biological Actions and Applications in Regenerative Medicine, Drug Delivery Systems and Food Industry KEAP1 SLC7A11 SIRT1 PMC6668978__F10 Schematic diagram shows the interplay of TGFB1, Notch, Shh signalling and Foxa in antler chondrocyte proliferation and differentiation TGFB1 SHH SMO NOTCH2 NOTCH1 PMC4590922__F4 The calgranulins, S100A8, S100A9, and S100A12, are secreted by cells of the myeloid lineage such as neutrophils and monocytes TLR4 S100A8 S100A12 S100A9 PMC6419612__F1 Metastatic progression in the bone CXCL12 LOX DKK1 PMC6056224__F1 Imbalanced expression/ activity of RAD18 and Y-family DNA polymerases dictates choice of TLS polymerases and can influence replication fidelity and genome stability RAD18 REV1 POLK POLI POLN MAGEA4 PMC9577232__F6 Targeting the cannabinoid system to counteract the deleterious effects of stress in Alzheimer’s disease BACE1 GSK3B CTNNB1 PMC6173361__F3 Comparative proteomic analysis of cat eye syndrome critical region protein 1- function in tumor-associated macrophages and immune response regulation of glial tumors NAPA TCIRG1 TAPBP PSMB6 CANX DNCL1 COPE VAMP3 HEL-S-269 TAP1 B2M TUBB HEL-S-99n LAMP2 TAP2 HLA-B HLA-A PMC3795238__F8 A model depicting androgen-AR-miR-29a regulation loop CDC42 IGF1 PMC5729470__F1 Differences in pathway activation between left-sided vs right-sided CRC ERBB3 STAT3 APC AK3 ERBB2 PTEN TCF4 SRC TYK2 AXIN2 PMC8456978__F2 New insights into the molecular mechanisms of axon guidance receptor regulation and signaling DCC ECD GDNF HEL-S-62p NRP1 SEMA3E RGMA EPHA4 ROBO1 NET1 FLRT3 SLIT1 LRIG2 EPHB2 ADAM17 C2 APP SRC RET PMC8224569__F6 Global Transcriptional Response of Aspergillus niger to Blocked Active Citrate Export through Deletion of the Exporter Gene LCT CS CIT PMC5823535__F1 Lessons from characterization and treatment of the inflammatory syndromes TRADD NLRP3 OTULIN RIPK1 TNF TRAF2 PMC7596324__F1 Mitochondria-targeted Therapies IL2 CTLA4 MTOR PMC6045629__F9 Mechanism of coagonism ZAP70 LAT ITK LCK PMC4716086__F1 Homeostasis and epidermal growth factor receptor downstream signaling pathway in keratinocyte HBEGF EREG TGFA EGFR GRB2 AREG PMC8612614__F3 Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench CRP GDNF BMP4 S100B PMC2947835__F2 Membrane proximal intracellular signals at the IS versus the HIV VS PLCG1 LAT GRB2 LCK PMC2704867__F5 Darpp-32 and Its Truncated Variant t-Darpp Have Antagonistic Effects on Breast Cancer Cell Growth and Herceptin Resistance EGFR PTEN PDK2 PMC8219171__F5 An Examination of the Putative Role of Melatonin in Exosome Biogenesis ATG10 ATG3 RAB8A ATG12 GSK3B ATG5 PMC8219171__F6 An Examination of the Putative Role of Melatonin in Exosome Biogenesis SLC2A4 TLE4 LRP5 LRP6 RYK FZD3 CSNK2A2 PLCG2 DKK1 PAX2 WNT1 EP300 MAP2K5 CSNK1A1 PMC6880659__F5 Proposed model of TFC pyroptosis in excessive iodine-promoted HT GSDMD NLRP3 IL1B PMC3884575__F2 Schematic representation of complement-mediated effects on T cells and APCs IFNG CD80 APC PMC12046282__F1 After CNPs enter cells through endocytosis, they induce the expression of TNFA and BMP2 STAT3 NLRP3 BMP2 XBP1 PMC3096194__F1 Cell cycle is controlled by the Rb pathway and p53 pathway TF CDKN2A CDK2 MDM2 CDK4 PMC3663521__F7 Schematic diagram illustrates the role of Dapper3 in UUO-induced renal fibrosis by regulating Wnt/Beta-catenin signaling MMP7 LRP5 LRP6 DAP CCND1 AXIN2 CTNNB1 PMC6709804__F2 Mechanism of response mediated by M1, M2, and M4 macrophages MMP7 STAT3 STAT1 MMP12 STAT2 IL16 TLR4 JAK3 IL4 IRF3 ARG1 JAK1 PMC8415634__F1 Emerging Mechanisms of Wnt Secretion and Signaling in Development APC LRP5 RYK ARHA CTNNB1 PMC5315281__F5 De novo assembly of the sea trout (Salmo trutta m. trutta) skin transcriptome to identify putative genes involved in the immune response and epidermal mucus secretion C1GALT1C1 B3GNT6 B4GALT5 PMC2063509__F1 AUTOPHAGY: HIGHLIGHTING A NOVEL PLAYER IN THE AUTOIMMUNITY SCENARIO ATG3 IGF1 IL4 MTOR TNF PMC8415634__F2 Emerging Mechanisms of Wnt Secretion and Signaling in Development RAB8A SNX3 PMC2491722__F4 Gdnf signaling pathways within the mammalian spermatogonial stem cell niche GDNF LYN SRC RET PMC2491722__F6 Gdnf signaling pathways within the mammalian spermatogonial stem cell niche GDNF CDK2 ATF1 GRB2 RET PMC7068464__F7 Schematic diagram showing that upregulation of large-conductance and Ca2+-activated K+ (BK) channel activity in activated hepatic stellate cells (HSCs) exerts an antifibrotic effect through suppressing of the profibrotic TGFB1 signaling pathway STAT3 TGFBI KCNMA1 TGFBR1 PMC5558548__F5 Sphingolipids as targets for treatment of fungal infections TH CERK SMS CER1 PC KDR MIP PMC7846556__F1 Inhibition of gasdermin D-mediated pyroptosis by necrosulfonamide, disulfiram, and dimethyl fumarate GSDMD IL1B PMC11294427__F2 S100A9 binds to Toll‐like receptor 4 (TLR4) to activate downstream pathways for biological effects NR1C1 NLRP3 TLR4 RHO S100A9 RAC1 MYD88 PMC2265304__F1 Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs? SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC11294427__F3 The S100A9‐receptor for advanced glycation end products (RAGE) signalling pathway in cardiovascular disease BMP2 S100A9 RUNX2 PMC4619615__F7 Structure-Activity Relationship of Synthetic 2-Phenylnaphthalenes with Hydroxyl Groups that Inhibit Proliferation and Induce Apoptosis of MCF-7 Cancer Cells CDC2 BAX FAS CDK2 CCNB1 CCND1 CDK4 PMC11616179__F2 Liver macrophages in liver fibrosis repair STAT3 MMP12 MMP9 PMC11616179__F3 LAMs and LCMs in liver injury TREM2 NLRP3 CX3CR1 MFN2 CCR2 PMC11616179__F1 Liver macrophage in the initiation and progression of liver fibrosis HMGB1 LOXL2 NLRP3 CCR5 CCR2 CCL5 MMP9 CCL2 TNF CCR8 CCL1 PMC8146072__F13 Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation BAX BAD CASP3 TNF PMC7998928__F1 Detrimental role of Formyl Peptide Receptor 1 (FPR1) in CVDs progression FPR1 IL6 IL1B PMC8146072__F10 Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation GLDC MTHFD2 PHGDH DHFR SHMT1 HIF1A ATF4 HEL-S-61p MTR KRAS HEL-S-51e PSPH PMC5891988__F2 ILC3s in the context of cancer LTB STAT3 LTA PMC11915259__F3 Microbiota disruption leading to an inflammatory environment TSC2 TLR4 IL6 MTOR PMC8281348__F9 Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells LATS1 TAOK1 TAOK2 LATS2 ANKRD1 MCC AXL DKK1 TAOK3 AIP MSC ARHA PMC3511325__F9 Protective Role of STAT3 in NMDA and Glutamate-Induced Neuronal Death: Negative Regulatory Effect of SOCS3 STAT3 BAX SOCS3 IL6 JAK1 PMC3279615__F3 Nucleotide excision repair (NER) pathway ERCC1 XPA PCNA CPD XPC PMC4587803__F3 NF KB signalling pathway C6 C7 HEL-S-62p C2 C4A PMC4610626__F2 Multiple activating human natural killer (NK) cell receptors and representative signalling pathways of 2B4, NKG2D, DNAM-1 and NKp46/30 ZAP70 SYK VAV3 LAT VAV2 PAK1 VAV1 GRB2 SRC RAC1 PMC7272438__F8 Proposed model for the involvement of miR-199a-3p and CAV2 in hepatic fibrosis TGFBR2 CAV2 SMAD2 TGFBR1 PMC4709508__F3 Toll-like receptors, adapter proteins, and signaling molecules TLR1 TIRAP TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 TLR7 TRAF6 MYD88 PMC6930809__F12 Potential mechanisms by which Meisoindigo protects against focal cerebral ischemia-reperfusion injury (CIRI) NLRP3 TLR4 CD14 IL1B PMC2771724__F3 Dopamine Receptor Signaling: Genes differentially expressed in the NAC of LE vs DRD1 DRD2 PDE10A PRKAG2 PMC2771724__F4 Synaptic Long-Term Potentiation: Genes differentially expressed in the NAC of LE vs MAPK1 PRKAG2 PPP3CA PMC6769439__F8 Possible mechanism of action underlying the protective effects of maltol against APAP-induced hepatic injury through inhibition of oxidative stress-mediated activation of the NFKB pathway and apoptosis and regulation of the PI3K/Akt pathway CASP9 CASP8 TRADD CASP3 APP FADD PMC7530368__F2 Mitochondrial dysfunction in kidney injury, inflammation, and disease: potential therapeutic approaches IFNG RIPK3 CGAS NOX4 IL1B PMC2584809__F6 Schematic model illustrating constitutive vs TH PNMT DBH NPY CADPS SNAP25 PMC8301439__F3 IDH Mutations in Glioma: Double-Edged Sword in Clinical Applications? GLS PDGFRA BCAT2 NAMPT BCAT1 PMC9228918__F7 ATM Pathway Is Essential for HPV–Positive Human Cervical Cancer-Derived Cell Lines Viability and Proliferation BRCA1 CHEK2 ATM PMC8616386__F2 Walking down Skeletal Muscle Lane: From Inflammasome to Disease IL10 GSDMD MAVS NLRP3 TXNIP IL1B PMC7641865__F8 The protective effects of hPMSCs on CD4+ T cells senescence FYN NQO1 GCLC GSK3B PMC9317022__F1 Innate Immunity Crosstalk with Helicobacter pylori: Pattern Recognition Receptors and Cellular Responses SYK TBK1 TLR9 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF6 IRAK4 MYD88 BCL10 TLR4 NOD2 TLR8 TLR7 CARD9 PMC5462452__F1 ROS in Cancer: The Burning Question MTHFD1 PRX ME1 HEL-S-26 HEL-S-44 PMC8616386__F6 Walking down Skeletal Muscle Lane: From Inflammasome to Disease GSDMD GHSR NLRP3 ADIPOR1 TLR4 PMC2670105__F1 IMP impedes Ras mitogenic signaling by limiting KSR1 complexes EGF KSR1 BRAF PMC3031545__F8 Regulation of Brown Fat Adipogenesis by Protein Tyrosine Phosphatase 1B FAS IGF1 UCP1 PMC4905708__F2 Coinhibitory pathways in the B7-CD28 ligand-receptor family HEL-S-92n CD80 APC LRBA PMC9024145__F3 Non-Coding RNAs in Sepsis-Associated Acute Kidney Injury CXCL12 PRKCI TLR4 UBL4A BNIP3L CXCR4 TUG1 PMC6891441__F1 Scheme of Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) function in the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway TBK1 CGAS IRF3 PDE12 ENPP1 PMC11034130__F2 Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy GGPS1 HEL107 FAS CD36 PTEN HIF1A CTLA4 FNTA TFAM ICOS FOXO1 STAT4 FOXP3 PMC4139724__F3 Functional features of gingivitis-associated microbiota FIGN FLI1 PMC6720954__F1 Upper, matrix metalloproteinase 1 (MMP1) cleavage of protease-activated receptors (PARs) result in increased Ca2+signaling MMP7 FAS MMP12 CXCL2 IFNG ICE1 CD74 IFNAR2 IFNAR1 CCL7 MMP2 IL8RB CCR1 PMC2928401__F8 Identification of Primary Gene Targets of TFAP2C in Hormone Responsive Breast Carcinoma Cells PRLR EPHB4 SHC1 SP7 ACD CD55 NCOA1 MYC BHLHB2 MTHFD1 COL18A1 SCARB1 IGFBP5 CRABP2 MYCBP2 BTC TP63 UNK PMC8773335__F5 Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach CD2 LAT C2 MMP2 MCU MMP20 MMP9 IL1B PMC11792030__F1 CoQ biosynthetic pathway IPP COQ4 COQ3 COQ2 COG2 COQ5 PMC7160660__F3 Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 transcription factor complexes RUNX1 CDS1 CNST FOXP3 MTOR PMC9214231__F3 Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe ATF1 MEI4 PMC10555542__F4 Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes Mellitus: A Randomized Controlled Trial SNAP23 FOXD1 RAB10 PIK3CA PLCB4 UPRT COL4A3 VAMP2 PTEN USP15 AHR CCND1 BAX VEGFA PHIP KRAS KLF15 CRK HMGCR EDN1 BCL2 EP300 SNAP25 GRB2 SESN2 PIGR GCNT1 PMC6986459__F1 Landscape of USP7 targets and modes of action.(a) The USP7–MDM2–p53 axis FOXO4 PTEN MDM2 NOTCH1 TRIM21 PMC7686287__F6 Schematic summary of high glucose activated NFKB pathway MMP7 STAT3 MMP2 JAK1 CCND1 IL1B PMC11034130__F3 Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy LPL CD36 FOXO1 STAT4 PTEN HIF1A CNST CTLA4 FOXP3 MYC VHL PMC11034130__F4 Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy CD27 CD36 GPX4 TNLG8A PTEN CTLA4 FOXP3 PMC8435685__F1 Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach DGCR8 ADAM17 ADAM10 DROSHA FURIN CTNNB1 PMC5343780__F1 Molecular mechanisms associated with inflammatory and oxidative stress in response to chronic exposure to PM0.1 KEAP1 AHR PTGS2 HEL-S-44 PMC12245507__F4 Ferroptosis signaling pathway TF GLS STEAP3 GPX4 HEL-S-64p PMC8773522__F1 Impact of Cancer Cachexia on Cardiac and Skeletal Muscle: Role of Exercise Training IGF1 SMAD2 MTOR TNF PMC4392874__F2 Network representations of the differentially expressed genes presented in pathway analysis DUSP10 ZAP70 EGFR WASL SMAD2 GSK3B PIK3R1 IL2RG STK4 PRKCZ NR1C2 PLA2G2D MTOR MYC IL11RA CR1 TNFRSF10A PRKAA1 CSNK2B GNB1 IFNG PLCG1 XCR1 INSR PI3 PDPK1 SRC CCND1 JUN PTPN11 VEGFA ARHA KRAS RAC1 FOS IRS1 CBL CXCR1 RPS6KB1 PLCB1 CSK ERBB2 BCL2 LYN MAP2K1 GRB2 TNFSF10 RRAS2 PMC5765207__F3 Developmentally regulated signaling pathways in glioma invasion HGF SMAD2 GSK3B SMAD4 MTOR CTNNB1 PMC9118284__F2 An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways TRADD NLRP3 TIRAP COX2 MMP2 MMP9 IL1B PMC9118284__F3 An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways BAX CASP9 CASP3 FADD PMC11923990__F9 Zbp1 Mediates central nervous system inflammation induced by AC via promoting macrophage inflammatory phenotypes CXCL9 CXCL10 PMC4971383__F1 Feedback loops that form the molecular clock PER3 PER2 CRY2 CRY1 NAMPT SIRT1 PMC11317487__F0 Graphical abstract and proposed pathway of rhMFGE8 administration attenuate hippocampal injury by improving neurogenesis in SAH models HPCA DCX MFGE8 MTOR CCND1 PMC5097173__F10 Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA RAD18 PCNA PIAS1 POLN PMC10813560__F8 Heatmaps were generated to visualise the notable pathways identified as significant by DIANA-miRPath (v RARA BAD AFP PMC4345914__F2 TLR signaling pathway and modulation effector molecules TBK1 TAB3 MAL TLR9 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR7 PMC5737877__F8 Proposed model for the regulation of BATF3 by S1P signalling in HRS cells S1PR1 S1PR2 SGPP1 SPHK1 PMC8263653__F14 Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture ADAM9 ADAM15 ASPH ADAM12 ADAM10 SRC INS PMC4142280__F4 Signaling crosstalk between the TGF-Beta-activated pathway and other pathways during EMT (according to Xu et al SMAD2 SMAD4 CTNNB1 PMC4630008__F1 Diagram of Hh signaling in mammalian cells STAT3 EGF ITCH BOC NRP1 GPC3 BMI1 ADRBK1 SUFU BCL2 MYCBP SMO RAB23 MDM2 ABCG2 GAS1 CCND1 WIF1 PMC4350105__F7 Genome-wide DNA methylome analysis reveals epigenetically dysregulated non-coding RNAs in human breast cancer STAG2 BRCA1 SMAD2 SMAD4 MYC TFDP2 PMC4630008__F2 Different roles of Hh signaling in cancer PTCH1 SMO MTOR PMC7027144__F3 Expression profiling of proteome reveals co-expression clusters and functional modules in HCC DBF4 MCM7 CTSO NCAPG ACADS ZWINT ACADL ACADM GINS1 MGMT PMC8622975__F3 Protective Effects of Equol (Soy Isoflavone Metabolite) on Coronary Heart Diseases—From Molecular Mechanisms to Studies in Humans TRADD TLR4 CCR2 IRF3 TRAF6 PMC2660327__F2 Network analysis using Ingenuity pathway analysis (IPA) software BAD BCL2 KDR SRC CTNNB1 PMC1847380__F14 Signaling pathways leading to pseudohyphal growth CDC42 SWI5 ACE2 PMC1847380__F15 Signaling pathways mediating the roles of Rho1 in cell wall assembly and actin organization ROM1 HMFT1766 SIM2 C2 PMC5377416__F11 Regulatory network construction for the overlapped genes CADM2 MTAP ERBB4 PER1 HNRNPD TLN2 CFH ZNF148 SMAD4 COPS8 IL17A PTGS2 NOTCH2 TRAF6 OTUD7B PTPRE NRAS PMC8908284__F3 Dualistic role of platelets in living donor liver transplantation: Are they harmful? STAT3 HGF IGF1 CCND1 PMC7049974__F1 Sterol reductases in cholesterol biosynthesis DHCR24 DHCR7 LBR PMC8047069__F2 Life Cycle of the Phagosome PI3 ARL8B EEA1 PMC6097257__F7 Merged network analysis from Ingenuity Pathway Analysis (IPA) software for associations among molecules related to rheumatoid arthritis, inflammation of joint, cell cycle and apoptosis LTBP1 CD40 PPARG AURKA ADAMTS15 ADAMTS14 SHOX UBE2C NFATC2 TUBB4B MLXIPL NR4A3 ZWINT CCNA2 HEL-S-99n EREG PRDM1 APOE HBEGF GFAP ADRB2 BDNF CP PTX3 CXCL12 IGFBP1 CILP TUBB2A TLR4 GADD45B GAS1 CD14 PTGS2 SDC1 CXCL6 STEAP4 CELF2 GMNN MKI67 PTTG1 ARHGDIB NUSAP1 CSGALNACT1 PTGIS USP2 ADRA2C SLFN11 MATN3 PTGES PTGER4 STC1 HCTP4 SKA3 PMC368431__F1 Sample view of a VisAnt application FAR1 PMC8894694__F4 Lipid rafts as viral entry routes and immune platforms: A double-edged sword in SARS-CoV-2 infection? CSA2 BCR TLR7 ACE2 MYD88 PMC6423593__F6 Pathview graph for the Kyoto Encyclopedia of Genes and Genomes term ‘calcium signaling pathway’ allows the visualization of the differentially expressed genes involved in this signaling pathway PLN CAV3 CAV2 BCR MCU CP PMC9022973__F2 Gal-8 on cytokine expression and secretion CD44 MRC2 MTOR TNF IL1B PMC7565128__F1 Hh pathway (inactive state and active state) and the crosstalk between Hh and EGFR pathways EGF JUN EGFR PTCH1 SHH PMC7565128__F2 Crosstalk between Hh signaling pathway and PI3K/AKT/mTOR pathway, Wnt/Beta-catenin pathway, Notch pathway JUN SOX9 APC PTCH1 LRP5 SHH LRP6 SMO MTOR CTNNB1 PMC6171019__F1 Signaling pathway with PLD1 participation was activated in LNCaP cells in the androgen-free environment BAD PC MTOR PMC3242363__F5 The mechanism of late PC STAT3 STAT1 JAK1 SRC LCK PMC3741132__F1 Application of Artificial Neural Networks to Investigate One-Carbon Metabolism in Alzheimer’s Disease and Healthy Matched Individuals RFC1 MTRR TYMS MTR PMC10300409__GA1 Oncolytic therapy with recombinant vaccinia viruses targeting the interleukin-15 pathway elicits a synergistic response IL15 IL15RA PMC8235796__F1 Expression of Wnt and TGF-Beta Pathway Components during Whole-Body Regeneration from Cell Aggregates in Demosponge Halisarca dujardinii APC GSK3B LRP5 KL LRP6 CTNNB1 TGFBR1 PMC6854717__F6 Mechanism scheme uncovers that CRISPR/Cas9-mediated knockout of NSD1 promotes H3K27me3 methylation and inhibits Wnt10b transcription, thereby suppressing activation of the Wnt/Beta-catenin signaling pathway WNT10B CTNNB1 PMC7456893__F1 Canonical and the non-canonical Wnt signaling pathways WNT10B WNT3A APC GSK3B ATF2 ARHA WNT10A WNT2B CTNNB1 WNT5B CD44 BCL9 COX2 WNT7A WNT1 WNT3 WNT4 WNT9A PMC7978298__F3 ROS induce cell death, mainly including apoptosis, necroptosis and ferroptosis GLUD1 SLC3A2 CASP9 PYGL FAS PIG59 TRADD SLC7A11 TIGAR TNF FADD PMC7978298__F1 Primary generation and elimination mechanisms of intracellular ROS ME3 MTHFD1 NOXA1 NOX3 MAL PRX FES ME1 HEL-S-26 NOX4 RAC1 PMC7961018__F1 Canonical TGFB signaling regulates the relationship between prenatal maternal depression and amygdala development in early life SMAD2 TGFBR3 SMAD4 PMC3001241__F1 MHC class II antigen processing pathways containing P MHC2TA PMC3001241__F2 Toll-like receptor signaling pathways containing P CD40 CD80 CASP8 TIRAP TLR9 CD14 IRF3 TRAF3 TRAF6 IRAK4 RAC1 MYD88 MAP3K7IP1 TLR3 KY TLR4 LBP FADD PMC9659230__F5A Reprograming of Gene Expression of Key Inflammatory Signaling Pathways in Human Peripheral Blood Mononuclear Cells by Soybean Lectin and Resveratrol SOCS1 IFNG BAX IRF9 IFIT3 IRF1 PMC9159819__F1 Neurobiological Links between Stress, Brain Injury, and Disease CORT BAX ATF4 MTOR EIF2A BDNF PMC7418744__F1 Pictographic representation showing the potential role of statins in COVID-19 infection IFNG HEL-S-92n PLG TNF PMC4276888__F7 Schematic of proposed TXNIP/miR-200/Zeb1/E-cadherin signaling pathway TXNIP PMC7560959__F7 Proposed metabolic pathway illustrating OTA nephrotoxicity HEL-S-22 KEAP1 PMC4243516__F1 Signaling partners of the p75NTR NGF MOG LINGO1 ARHA TRAF6 PMC9125939__F8 NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway NFATC1 NOX4 PMC9355645__F7 Transcriptome and Metabolome Analyses Reveal Differences in Terpenoid and Flavonoid Biosynthesis in Cryptomeria fortunei Needles Across Different Seasons HMGCR DHDDS WAS CPD MVK PMC3159106__F2 TLR-mediated myeloid differentiation primary response gene 88 (MyD88)-dependent and TIR domain containing adaptor inducing interferon (IFN)B (TRIF)-dependent signaling pathways TBK1 TLR1 LTA TIRAP TLR4 TAB3 CD14 TLR5 IRF3 TLR7 TRAF6 MYD88 PMC3492958__F1 Distinct roles for AlphaB hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling LPA NR1C1 PDPK1 PLIN1 PC IRS1 PMC7834960__F3 These pathways play an important role in cell growth, proliferation, and homeostasis, thus, a mutation in anyone may cause cancer cell survival, division and metastasis SUFU EGFR SMAD2 APC SMAD4 SHH SMO PTEN GRB2 MTOR CTNNB1 GLI3 PMC7834960__F4 Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review) LATS1 KEAP1 MDM2 FADD PMC5557756__F7 Schematic of a mechanosensitive pathway whereby low magnitude SS acts through the ER stress response pathways XBP1 and eIF2A to promote IRF-1-mediated VCAM-1 expression and VLA-4-dependent monocyte adhesion IRF1 VCAM1 EIF2A XBP1 PMC8576642__F7 Berberine attenuates atherosclerotic lesions and hepatic steatosis in ApoE-/- mice by down-regulating PCSK9 via ERK1/2 pathway PCSK9 VCAM1 MTOR TNF ABCA1 NOX4 SIRT1 IL1B PMC6945027__F5 Model for the regulation of the Hippo pathway by Vgll3 and Akap11 LATS1 LATS2 TEAD2 TEAD3 VGLL3 AKAP11 ARHGAP18 ARHA ARHGAP29 TEAD4 PMC3159106__F3 TLRs crosstalk with the phosphoinositide 3-kinase (PI3K) signaling pathway TLR4 TAB3 MTOR TRAF6 MYD88 PMC1636849__F8 Schematic summary of the signaling pathway leading to Nanog repression SOX2 ZFP42 GATA6 GRB2 PMC4582187__F7 Model describing the modulation of MLP quality control at the proteasome by BAG6 and SGTA TPR UBL4A BAG6 SGTA PMC4101967__F2 Interference with type I IFN-activated JAK/STAT signaling pathway and antiviral ISGs STAT2 IFNAR2 IRF9 IFNAR1 ISG15 TYK2 KPNA1 PMC8710575__F1 Gut Dysbiosis and Intestinal Barrier Dysfunction: Potential Explanation for Early-Onset Colorectal Cancer STAT3 TGFBI PAH CTNNB1 PMC5474518__F75 Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3B Signaling Pathway BAD GSK3B CH25H PMC8724616__F1 IGF1–PI3K-induced physiological cardiac hypertrophy: Implications for new heart failure therapies, biomarkers, and predicting cardiotoxicity IGF1 IGF1R PMC8904924__F1 Updated Review on Ozone Therapy in Pain Medicine IL10 KEAP1 IL13 NQO1 IL4 IL2 IL7 IL6 PMC6757020__F10 Illustration of pathway signalling where phosphorylation signalling PTMs have been sequenced and annotated in melanoma tumours from patients PAX3 CDKN2A MC1R BCL2 SOX10 MTOR CDK4 PMC5671526__F8 Schematic representations of potential mechanisms of PEBP1 in enhancing inflammatory response and neuron apoptosis after I/R injury IL6 IL1B HEL-S-34 PMC4423995__F1 Netrin-1 – DCC Signaling Systems and Age-Related Macular Degeneration RYR2 CACNA1A DCC CACNA1C NTN1 NFATC3 PMC4282344__F1 Pathways implicated in Alzheimer's disease (AD) SLC24A4 CELF1 SORL1 ZCWPW1 APOE BIN1 INPP5D TREML2 CASS4 PTK2B EPHA1 CR1 FERMT2 PICALM TREM2 CLU PSEN2 APP PMC6078181__F2 Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap CCL3 APC CFTR CCL4 CXCL10 IL1B PMC4254744__F6 HMGB1 Promotes a p38MAPK Associated Non-Infectious Inflammatory Response Pathway in Human Fetal Membranes HMGB1 TLR4 MYD88 PMC2787631__F7 Working model of PKA’s role in trastuzumab resistance EGFR PTEN PDK2 PMC4760904__F6 Agrin and LRP4 are central to a chondrogenic signalling network ACAN LRP4 SOX9 DKK1 LRP5 LRP6 COL2A1 PMC5086377__F1 TNF signaling pathway anomalies through antiapoptotic signaling by TNFR1 helped by upregulation of TRAF1 and inhibition of proapoptotic TNFR1 signaling by BIRC1/3 caspase inactivation CD40 TRADD IL2 STAT4 LYN MYC TRAF2 FADD PMC6263441__F1 Comparative Genomics Supports Sex and Meiosis in Diverse Amoebozoa MSH4 MSH6 RAD21 REC8 MSH2 SPO11 DMC1 SMC3 PMC6452301__F4 Interplay of well-known germline and somatic mutations in atherogenesis PCSK9 LPL SORT1 ANGPTL3 APC LDLR APOA5 IL1B PMC8645963__F1 Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer ME3 ME2 NADK ME1 HEL-S-26 PMC8645963__F2 Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer ME3 ME2 HEL-S-162eP NADK ME1 HEL-S-26 PMC7500474__F1 11-Oxygenated C19 Steroids Do Not Distinguish the Hyperandrogenic Phenotype of PCOS Daughters from Girls with Obesity HSD3B2 CYP17A1 HSD11B2 SULT2A1 PMC5825090__F1 The folate pathway in pancreatic cancer risk MTHFD1 HEL-S-182mP DHFR PEMT CTH PC CHDH MTRR HEL-S-61p TYMS MTR PMC4972972__F1 Dual regulation of GSK3 by the PI3K/Akt/GSK3 pathway and PLIN2 APC LRP5 LRP6 ADFP CCND1 IRS1 CTNNB1 PMC2757186__F9 Working model for the biochemical cascade leading to the AR PMC3032584__F1 NF-kappaB, a mediator for lung carcinogenesis and a target for lung cancer prevention and therapy LTB TRADD RELB TRAF2 PMC6628025__F1 Fibroblast growth factor receptors (FGFRs) are highly conserved transmembrane receptors consisting of three extracellular immunoglobulin-like (Ig-like) domains, a transmembrane helical region, and a cytoplasmic region with kinase activity FRS2 GRB2 PMC6707858__F1 Role of the Endolysosomal System in Parkinson’s disease VPS35 PINK1 LRRK2 VPS13C PMC6959064__F2 Calreticulin-mediated LMP1 signaling network that promotes EMT in NP69 cells KRT18 SSBP1 HEL113 SIRT7 MAPK13 HEL-S-269 CS KRT19 HEL-S-99n PLAT RIPK2 tmp_locus_29 KRT5 SP1 ANXA2 TUBB NR3C1 HDAC1 ITGB1 CUL4B CASP3 CFTR HLA-B AK4 RBM3 LMNA PMC4005015__F9A DIETARY HYPERGLYCEMIA, GLYCEMIC INDEX AND METABOLIC RETINAL DISEASES HEL-S-133P VHL PMC7521521__F1 Cullin-RING E3 ligases (CRLs) and the NEDD8 conjugation pathway FBXW8 RBX1 DDB1 SKP1 PMC6613878__F1 Therapeutic strategies targeting NAMPT against stroke BAX TSC2 NRK NAPRT NAMPT SIRT2 MTOR SIRT1 PARP1 SIRT6 PMC8699548__F2 Multicellular Effects of STAT3 in Non-small Cell Lung Cancer: Mechanistic Insights and Therapeutic Opportunities STAT3 EGF EGFR IL6 IL6R PMC7281185__F1 Impact of nitric oxide (NO) in senescence-mediated signaling pathways CXCL12 STAT1 COX2 CXCL1 ATM CCL5 CCL2 PMC6131595__F5 Metabolic reprogramming in cancer cells TIGAR PMC9587781__F3 Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease NLRP3 UNG IL1B PMC3524013__F3 Full network comparison of the original canonical pathway and the inferred cell-type-specific pathway TGFA RAF1 MAP3K1 IGF1 EGFR MAP3K7 IL1A GRB2 TRAF2 IRS1 PMC9587781__F1 Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease C6 C7 C5AR1 HEL-S-62p C2 C9 PMC11099588__F1 Biological functions of Amot family proteins and associated signal transduction pathways RICTOR NEDD4 PATJ PDLIM2 AMOT ARHGAP17 AMOTL2 AMOTL1 PALS1 MTOR YAP1 PMC7851309__F8 Neuroprotective Activities of Long-Acting Granulocyte–Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice SOCS1 PPARG ID2 NFATC2 NR4A3 IRF1 TGIF1 PTGDR2 GFI1 RORA NFATC2IP IL1R2 CCR6 MAF CCR4 FOXP3 JAK1 REL PMC9587781__F2 Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease CD59 C5AR1 IL16 TNF PMC6072627__F2 Intracellular activation of innate immune signaling by hyaluronan matrix CD44 TIRAP TLR4 TLR5 ARHA MYD88 PMC6566080__F9 Cytokine-cytokine receptor interaction signaling pathway map in the male group IL15 CD40 CXCR3 CXCL12 OSM CCL3 CCR5 CCR2 CCR3 CCL5 CXCL3 MPL IL1R2 IL17B CCL21 CCR6 IL17RB CCR7 IL2 TPO IL11 CCR1 IL1B IL13 LIF IL4 IL7R CD40LG IL1A IL6 CXCL6 TNF CXCL10 CNTF TSLP CCL4 IL7 CXCR4 IL23R CCL20 IL23A PMC8630747__F5 Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1B STAT3 HIF1A PMC7954711__F1 The B6 vitamers pyridoxal (PL), pyridoxine (PN), pyridoxamine (PM) and the respective phosphate esters pyridoxal-5′-phosphate (PLP), pyridoxine-5′-phosphate (PNP) and pyridoxamine-5′-phosphate (PMP) PNP PDX1 PC HEL-S-1a PMC6566080__F8 Hematopoietic cell lineage signaling pathway in the male and female groups IL3 CD7 CD14 CD22 CD19 CD34 CD44 CD24 ICE1 CDA CD37 CD33 CDS1 HEL-S-11 TPO PMC8304501__F1 Oncolytic Virus-Induced Autophagy in Glioblastoma RHEB TSC2 TSC1 UVRAG PTEN MTOR PMC8745434__F1 Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time HHIP KIF7 SUFU PTCH1 DISP1 SMO ARHA CCNB1 GAS1 RAC1 GLI3 PMC129737__F5 Model for repair of camptothecin-induced replicative damage TDP1 RAD1 PMC4283622__F1 Capecitabine activation and subsequent 5-FU activation, action, transport and catabolism CES2 CDA TK1 RRM1 RRM2 UCK2 DPYS DPYD UPP2 TYMS UMPS TYMP PMC3548426__F1 Telomere syndromes NHP2 GAR1 NOP10 CTC1 STN1 TERT TEN1 POT1 TPP1 PMC5342330__F9 Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells STAT3 SOX2 NUMB IGF1R SRC NOTCH1 LNX1 PMC6855070__F2 Molecular pathway signaling of angiogenesis-induced epithelial-mesenchymal transition in hepatocellular carcinoma TGFB1 HGF VEGFA PMC3137145__F3 Cigarette smoke exposure induces autophagy and apoptosis EGR1 ATG3 ATG12 ATG5 PMC2643977__F4 Proposed integrated model for local water transport inhibition by activation of P2Y2 and adenosine A1 receptors (A1R) in inner medullary collecting duct principal cell AQP4 AQP2 AQP3 AVP PMC11647666__F11 Reduction reactions dominate the interactions between Mg alloys and cells: Understanding the mechanisms ROR1 CCN4 TRPM7 EGFR APC ROR2 BNIP3 MTOR CTNNB1 RHEB TSC2 TSC1 SOX9 FOSL1 PMC5650456__F1 Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma EGF CD80 NGF CEACAM1 TGFA EGFR BRAF NRAS KIT BCL2 LAG3 PMC2716541__F6 Apoptosis of CD4+CD25high T Cells in Type 1 Diabetes May Be Partially Mediated by IL-2 Deprivation FAS CITED2 TNFRSF10B CCND2 CDKN1B GADD45B BCL2 PTEN SESN1 GADD45A PMC2881756__F7 Model illustrating the role of WDR3 in mediating cross-talk between ribosome biogenesis and p53-mediated cell cycle regulation WDR3 RPL11 MDM2 PMC3299554__F1 Diagrammatic representation of the Akt signaling pathway.Notes: Activation of receptor tyrosine kinase (RTK) by growth factor binding activates PIK3 BAD PTEN MDM2 MTOR CCND1 PMC4829553__F4 Genes positively and negatively connected to the expression of Egfr in the mouse liver CSA2 E2F4 FOXB1 EGFR RANBP1 TRAM1 TFG SI SLAMF9 SEC61B HNRNPK IKBKG PMC4059147__F5 Scheme for GAG biosynthesis (chondroitin/dermatan and heparan sulfate synthesis and keratan sulfate synthesis pathway) (A) and degradation (B) CHST14 HPSE GUSB HGSNAT CHST7 CHPF HPSE2 IDUA GLCE HEXB HEXA B3GALT6 HS6ST1 GNS SGSH GALNS EXT2 EXTL2 CHST12 HYAL2 UST HYAL3 HYAL4 PMC9610022__F3 High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models AMH MTOR PMC4548049__F2 Inborn errors underlying herpes simplex encephalitis: From TLR3 to IRF3 TBK1 CGAS TLR3 IRF3 TRAF3 PMC9106715__F8 Working model displays the mechanism of which RP1-59D14.5-modulated PCa tumorigenesis and progression LATS1 LATS2 TEAD2 TEAD3 TEAD4 PMC5391049__F1 Wnt Signaling and Colorectal Cancer WLS TNKS2 RNF43 PORCN APC GSK3B MYC GPR49 AXIN2 CTNNB1 LGR6 PMC4829553__F3 Sex Difference of Egfr Expression and Molecular Pathway in the Liver: Impact on Drug Design and Cancer Treatments? CSA2 EHHADH FKBP11 CPB2 GDPD1 EGFR PTDSS1 GNAT2 SSR1 DGCR6 SLC37A3 FARP1 SEC61G RNP24 SLC27A5 IKBKG E2F4 AK2 HEL-S-2a SI HNRNPK FOXB1 RANBP1 TRAM1 TFG SLAMF9 SEC61B MIF PMC2538513__F2 The involvement of death receptor pathway (right half) and mitochondrial pathway mediated (left half) apoptosis in nurse cell formation TRADD TNF APAF1 TRAF2 FADD PMC2538513__F4 Schematic illustration of the involvement of c-Ski and TGFB signaling pathway in nurse cell formation SMAD2 SMAD4 SKI PMC3086210__F9 NH2-terminal Propeptide of Type I Procollagen Acts Intracellularly to Modulate Cell Function SMAD4 TGFBR1 PMC10532419__F3 LOXL2 in Cancer: A Two-Decade Perspective TRIM44 LOXL2 SP1 ZEB2 EGFL7 FOS ZRANB1 KDM4C PMC10532419__F4 LOXL2 in Cancer: A Two-Decade Perspective VEGFC LOXL2 PMC9229135__F2 Clinical Escherichia coli: From Biofilm Formation to New Antibiofilm Strategies FIGN FLI1 PMC8113272__F2 Genomic network analysis showing the central role of genes related with cell cycle pathway ATR GSK3B MYC THRA RPL5 CTNND2 WT1 RARA CAMK2A CAMKK2 SALL4 SOX9 SNAI1 NDN F2R RARB ZBTB7A PBRM1 CTBP1 NPM1 POMC CSNK2A1 TBX3 SMO ZEB2 MDM2 F2RL1 STX1A RXRB CCND1 MGMT CDK4 MAPK1 TIMP3 ASXL1 LRP6 TFAP2A YBX1 TBX5 CD44 RUNX1 IKBKB RXRA PIR MCM3 ADAM10 IFNB1 TWIST1 PMC6306679__F4 Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy NAMPT NMNAT2 NNT NMNAT3 PMC8192371__F1 Beyond Microsatellite Instability: Evolving Strategies Integrating Immunotherapy for Microsatellite Stable Colorectal Cancer CD40 HEL-S-92n TLR4 EGFR LAG3 PMC5562708__F7 IRS4 interferes with BMP signal transduction and functions as a novel regulator of BMP signalling and myogenesis SMAD1 DKFZp781O1323 GSK3B SMAD4 IRS4 MTOR ID1 PMC5101720__F8 Pathway analysis using the KEGG Pathway database REN RPN2 RP2 RPN1 ARC PMC5101720__F7 Pathway analysis using the KEGG Pathway database RPE REN RPN2 RP2 ARC PMC3058357__F3 GRAIL and Otub1 regulation by the mTOR pathway controls naïve CD4 T cell proliferation IL2 MTOR PMC6895440__F2 Several typical post-translational modifications of PGK1 HDAC3 HEL-S-68p PDPK1 EGFR MTOR PIN1 PMC11464892__F7 IL-17 signaling pathway in CD 138 + MM cells USP25 TH IL17RC S100A7 TAB3 MMP3 APP MMP9 TNF FADD PMC6895440__F3 PGK1 involvement in drug resistance DNMT3B HEL-S-68p FOSL1 HIF1A PMC8913496__F1 RhoG’s Role in T Cell Activation and Function STIM2 ARHG ORAI1 STIM1 APC JAK3 IL7R JAK1 PMC6594866__F2 Key cytokines and transcription factors involved in the regulation of megakaryocyte maturation MPL GATA2 NFE2 FLI1 GATA1 IGF1 ETV6 TPO CCL5 IL1B PMC8074291__F7 Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells STAT3 IL16 EGFR BCL2 IL6 MTOR TNF PMC3240668__F6 Fibronectin - c-Myc network FUS FSHR CTNNB1 BTK OAS2 RPL31 RPL12 KLF6 GDI2 MNT APC RPS19 KHSRP HEL-S-28 E4F1 HEL70 TINAG VEGFA SHE RPL23 ABCB10 PSMC4 HRAS NPC2 RPL15 HNRNPF RPS20 MCM3 RPL4 ENO1 GRB2 PMC8533551__F1 Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis BMPR2 ENG BMP2 PMC7490524__F1 Alternative splicing rewires Hippo signaling during chronic liver injury and HCC ESRP2 MBNL3 SOX2 NF2 PMC3584681__F2 Pattern-recognition receptors (PRRs) and signaling pathways that lead to differentiation of antifungal T helper (Th) cells TH NLRP3 BCL10 MAL RELB IRF3 UNK IL1B CARD9 MYD88 PMC4488795__F2 Hepatic lipid homeostasis is regulated by LRP6 PCSK9 TG FAS LDLR LRP6 ELOVL6 PMC3016145__F1 Intracellular and extracellular chromogranin/secretogranin actions SCG2 CHGB NPY PMC4783290__F7 Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development MCC PDC ETV4 CS PMC6732626__F7 In the DP-treated cells, DP preferentially recognized and activated EGFR receptors on the cell surface EGFR MTOR PMC5742578__F1 Structure and function of ARNAX MAVS TLR3 TICAM1 IRF3 PMC3472468__F4 Effects of sleep deprivation on the insulin signaling pathway EXOC7 SOCS2 MTOR FOS EIF4E RHEB TSC2 TSC1 INSR FOXO1 PPP1R3G PPP1R1A PPP1R7 PMC7331746__F3 Essential functions of mitochondrial dynamics in immune cells CD40 IFNG MFN2 IRF1 CD163 PMC6296478__F1 Post-transcriptional regulation of cytokine expression and signaling ECSIT MAP3K7IP1 RUNX1 SP1 STK4 SOCS3 TRAF6 TNFSF10 RUNX3 MYD88 PMC7331746__F4 Essential functions of mitochondrial dynamics in immune cells RIPK3 MFN2 PDC CD14 MTOR TNF BIK PMC9319897__F5 Plasma Oxylipins and Their Precursors Are Strongly Associated with COVID-19 Severity and with Immune Response Markers CRP LOX IL18 GLA IL7 IL6 CXCL10 CCL2 IL1B CCL17 PMC7331746__F2 Essential functions of mitochondrial dynamics in immune cells CD80 OPA1 MFN2 IRF1 PMC4741699__F1 Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors SMAD9 SMAD1 DKFZp781O1323 EGFR SMAD2 PTEN MTOR SHE KRAS CD44 GSK3A PAK1 MDM2 TYK2 PMC12138068__F2 Phosphorylation and collagen-related diseases STAT3 STAT1 FOXM1 DDR1 TIMP1 SMAD2 APC LRP5 PEBP4 LRP6 IRF3 IL1B PMC11944037__F11 Biomarker-pathway-target network diagram of IPE anti-RA DHFR BST1 PTGS2 ARHA MAPK8 MAPK14 ALB PNP HEL-S-49 MAPK10 LCN2 SRC TYMP PMC4301309__F1 Central role of NMPRTase (Nampt*) in the salvage pathway for NAD biosynthesis and related cellular functions NMNAT1 NAMPT NMNAT2 NMNAT3 PMC12138068__F4 Ubiquitination, SUMOylation, methylation and collagen-related diseases PRMT1 TRIM13 PRMT3 EGFR FGFR3 EZH2 SENP2 SMURF2 PMC8424979__F5 Tetraploidization event shaped the Aquilaria sinensis genome and contributed to the ability of sesquiterpenes synthesis IPP HMGCR MVD FDPS PMC8804219__F2 Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products EMP1 FTH1 TFRC ANGPTL4 SLC40A1 GCLC MAF FACL4 SLC7A11 GLS2 HEL-S-64p RPA1 PMC7509998__F1 Pathway activation of Notch signalling receptors and their downstream signalling molecules JAG2 FURIN PMC9490047__F1 Current applications of adipose-derived mesenchymal stem cells in bone repair and regeneration: A review of cell experiments, animal models, and clinical trials LRP5 LRP6 RUNX2 CTNNB1 VHL PMC2574011__F1 Store-operated Ca2+ entry in T cells ORAI1 LAT FOXP3 LCK PMC5797066__F3 Decorin and downstream signaling cascades in tumor cells HEL164 TIMP3 EGFR PEG3 ARHA MTOR VEGFA MYC PMC10968131__F5 EFNA4, FGFR4, SLC3A2, and HNF1A are involved in signaling pathways that may promote carcinogenesis SLC3A2 RAF1 PIK3CD APC BRAF MTOR CTNNB1 ARAF HRAS FGFR4 MDM2 GRB2 HNF1A ERAS PMC8804219__F1 Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products IREB2 VDAC3 SLC3A2 FBXL5 HEL60 TGFB1 KEAP1 GPX4 SMAD2 LPCAT3 FACL4 SMAD4 SLC7A11 STAT1 FTH1 IPP FTL HMGCR STEAP3 NQO1 GLS2 HEL-S-64p HEL-75 PMC6434238__F2 Network for abnormal sub-pathway JRK CALML6 PIK3R5 SOS1 GYS2 PPP1CC PIK3R2 PPP3R1 AKT3 GSK3B RPS6KA1 SLC38A3 SMAD4 PTEN IGF1R YLPM1 PPP3CA PPP2R5C MAP3K14 FGFR2 RB1 RARA CAMK2A CCND2 CCND1 JUP RBL2 KRAS FGF2 FOXO3A CDKN1B PPP1R1A CDK2 GRB2 SEMA3B PMC3275089__F1 Schematic overview of the ABeta-Cav1.2-ptau-autophagy pathway CAV2 APP CALHM1 PMC3936506__F3 Cell Cycle Regulators Guide Mitochondrial Activity in Radiation-Induced Adaptive Response BAX SSB CCND1 PMC7578249__F4 Impaired monocytes function in ACLF CD80 TLR4 CCR2 IL33 MERTK PMC7098821__F1 Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease PINK1 FGF21 GDF15 PMC4169465__F1 The Role of Iron in Prion Disease and Other Neurodegenerative Diseases TF STEAP3 CP PMC9066069__F3 High‐fat diet (HFD)‐induced reprogramming of the hepatic clock and metabolic homeostasis NAMPT SIRT1 PMC7656422__F1 Immune suppression of Tregs via trans-endocytosis of CD80/86 from APCs CD80 PMC7037210__F1 Main anticancer molecular mechanisms mediated by cannabinoid receptors’ activation “↑, upregulation” and “↓, downregulation” BAX BAD ATF4 ARHA MTOR SRC CTNNB1 PMC8227118__F7 Genome-Wide Differential Methylation Profiles from Two Terpene-Rich Medicinal Plant Extracts Administered in Osteoarthritis Rats BAD RAF1 PTEN CD19 MTOR RAC1 PLEK RHEB ELF4 TSC2 BCR CD37 PI3 MDM2 PMC10917649__SF6 Mapping of the identified gene classes of MetaCyc PWYG-321 mycolate biosynthesis to the KEGG ko00061 fatty acid biosynthesis pathway MECR OXSM FAS HEXA HTD2 CBR4 FASN FES CP PMC8582545__F1 Disruption of Tumor Suppressors HNF4A/HNF1A Causes Tumorigenesis in Liver STAT3 TRADD TRAF2 PMC7350758__F1 Vital signaling pathways and important substrates for downstream regulation of USP4 USP4 SMAD4 TCF4 NLK HDAC2 TRAF2 CTNNB1 PMC11817781__F4 Top 10 genes and associated critical phenotypes network HMOX1 PLAT GDNF SQSTM1 PMC12199322__S1 Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway STAT3 HMGB1 PMC5814137__F4 Heterocellular nutrient symbiosis in the tumor microenvironment.Tumor-associated stromal cell populations engage in cooperative metabolic processes with cancer cells in the tumor microenvironment MSC TEF CIT PMC5673281__F3 Bile acids as global regulators of hepatic nutrient metabolism SPHK2 EGFR SRC PMC2118421__F7 Proposed model of RasGRP1 in FcɛRI-mediated signaling SYK FYN LYN ARHA GRB2 PMC5668920__F1 Fas apoptotic pathway FAS NRAS LRBA PMC7327349__F1 Graph of the IL-17 signaling pathway in KEGG database MPL ELL PLG MMP3 LCN2 MMP9 FADD PMC3004266__F10 Active Cdk1/cyclin B1 complex on the extrinsic death pathway CDC2 FAS CCNB1 FADD PMC10546379__F7 SIK2 on Wnt/Beta-catenin signaling pathway PHLPP2 SIK2 LRP6 HEL-S-26 PMC6609682__F7 IFITM3 promotes bone metastasis of prostate cancer cells by mediating activation of the TGFB signaling pathway SMAD2 IFITM3 SMAD4 PMC10217969__F5 Transcriptome and Metabolome Reveal Distinct Sugar Accumulation Pattern between PCNA and PCA Mature Persimmon Fruit FAS TREH GYG1 PMC11083682__F3 Influenza viral degradation of cellular proteins that do not directly regulate IFN signaling MOV10 CCND3 FBXO6 EIF4B ITCH CHD6 PML HDAC1 STAT1 NLRX1 IFITM3 CFTR HDAC11 MDM2 SSU72 HDAC2 GPS2 HEL-S-44 HDAC6 PMC10546379__F4 SIK1 inhibits tumor cell EMT by suppressing Beta-catenin signaling pathway and the expression of Twist 1 SIK1 TCF4 LEF1 CTNNB1 PMC11083682__F2 Influenza viral degradation of cellular proteins involved in the interferon responses SOCS1 DNMT3B NBR1 IFNGR1 IFNLR1 FBXO45 MAVS RNF5 IRF9 IRF3 TRAF6 PARP1 STAT1 IFNGR2 IFNAR2 IFNAR1 JAK1 TYK2 PMC2820418__F12 PRG5 signaling in axon growth and neurite retraction CDC42 LPA ARHA PMC7723774__F1 Preparation of the chitosan/sodium alginate (CA/SA) hydrogel simultaneously loaded with parathyroid hormone fragment PTH(1–34) and nano-hydroxyapatite for promoting cranial bone regeneration via the Notch signaling pathway BMP2 PTH RUNX2 HES1 HES5 PMC12249179__F8 Correction: Ye et al. The Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer. Cancers 2022, 14, 2101 PMC8358831__F3 Emerging Perspectives on Leukemia Inhibitory Factor and its Receptor in Cancer LATS1 LATS2 LIF SCRIB AREG PMC6120108__F2 The BDNF/ TrkB signalling in normal and glaucomatous conditions PLCG1 ATF4 GRB2 EIF2A BDNF PMC8495202__F2 Desmosomes as Signaling Hubs in the Regulation of Cell Behavior EGF PKP2 EGFR PKP1 DSG1 DSG2 PKP3 DSG3 DSG4 DSC1 PMC6120108__F3 Downstream consequences of neurotrophin signalling pathway affecting gene function and ER stress marker is possibly implicated in progression of RGCs axon damage in glaucoma MYOC ATF6B TMCO1 UBC ATF4 EIF2A OPTN XBP1 WDR36 PMC4716813__F2 Angiotensin-(1-7): A Novel Peptide to Treat Hypertension and Nephropathy in Diabetes? ACE2 PMC8980962__F5 JAK/STAT: Why choose a classical or an alternative pathway when you can have both? STAT3 IL2RB JAK3 EPO PMC8980962__F2 JAK/STAT: Why choose a classical or an alternative pathway when you can have both? STAT3 STAT2 STAT4 JAK1 IL23R TYK2 PMC11591759__F1 Two possible options for the interaction of Notch signaling pathway targets (Hes1, Hey1) with Runx2 RUNX2 HES1 PMC1847591__F1 Drugs that regulate hepatic bile acid and other organic solute uptake, synthesis, detoxification and secretion CYP7A1 SULT2A1 CYP3A4 PMC10244093__F9 Linc00662 m6A promotes the progression and metastasis of pancreatic cancer by activating focal adhesion through the GTF2B-ITGA1-FAK pathway GTF2B ITGA1 IGF2BP3 SRC PMC6849407__F8 Schematic diagram of the potential mechanisms for CDDO-Me–mediated Nrf2 activation in CHF AREL1 KEAP1 COX2 NQO1 GCLC PMC8678517__F2 Novel Pathways for Targeting Tumor Angiogenesis in Metastatic Breast Cancer TGFBR2 BMP10 ACTR2 SMAD9 SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC10970410__F8 Transcriptional Regulatory Networks (TRNs) based on DE pcRNAs common to KLF4KD and MXD4KD cells, in association with lncRNAs H2BC12 CD226 FAT4 MMP16 SCN8A LCP1 ADAMTS14 PRKD1 OXTR SPRR4 HS3ST3A1 SELPLG NEK2 HEL-S-10 MGST1 NR4A3 KALRN PLA2G4C SCUBE3 CEP70 ATOH8 CHSY3 ST3GAL1 WNT5B GBP4 BAMBI JAM2 NTNG1 FZD8 CYP4F11 CENPH GSTA4 RPA3 ID4 SPC24 CDKN3 CTGF CDH2 CACNA1A PRR9 EDN1 HAS2 BDNF PTX3 HEL113 PLCB4 RORA TPM1 GUCY1A2 CX3CL1 CCND1 GBP2 JUN GDNF TLN2 IL6 PITX2 FGF7 PTTG1 TLR1 ITGA1 HEL-S-75 WWC1 XYLT1 RGS4 DKFZp686P11128 BMPER CA9 ApoL6 HAUS4 PPP2R5A PMC4731439__F1 TNFAlpha-related signal transduction pathway participating in the differentiation of skin appendages TRAF3 EDARADD TRAF6 FURIN EDAR CYLD PMC7591509__F4 Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis LTB LTA ALOX5 ALOX15 ALOX12 PTGES PMC4731439__F2 Interaction of proteins involved in signal transduction via the TNFAlpha-related signal transduction pathway (based on http://string-db.org, simplified) UBC MAP3K7IP1 TRAF6 FURIN CYLD TNLG7C PMC8146983__SF1 Toward an Understanding of the Structural and Mechanistic Aspects of Protein-Protein Interactions in 2-Oxoacid Dehydrogenase Complexes GCDH AASDH AADAT AASS PMC11683013__F2 CGAS-STING pathway activation, Chinese medicine inhibits or activates cGAS-STING signaling pathway to treat various diseases TBK1 CGAS IRF3 IL6 PMC2971525__F1 DNA Damage Response (DDR) pathways in normal and malignant cells BAX ATR FAS FOXO1 H2AX CDK2 PMC8835786__F3 SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19 TBK1 IRF3 TRAF3 PMC3823115__F3 Potential mechanism of the HGF/ c-Met signal pathway hallmarks in lung cancer HGF EGFR MTOR PMC3823115__F1 TGFa/EGFR signal pathway may directly or indirectly lead to c-Met, while HGF/c-Met does not affect the phosphorylation of EGFR HGF TGFA EGFR ANXA1 PMC6923165__F3 Time-dependent changes of gene expression of the KRAS signaling pathway after treatment of PDAC model cell lines differing by the KRAS mutation status with paclitaxel in vitro PIK3CA RAF1 GSK3B BRAF PTEN MTOR ARHA PTK2B KRAS RAC1 ARAF RALA PDPK1 PAK1 PI3 RIN1 PRKCA MAP2K1 MAP2K2 RALBP1 PMC7913947__F1 The kynurenine pathway HEL-S-90n KMO PMC6328617__F1 CD44v6 engages in colorectal cancer progression CD44 MMP2 MMP9 SRC CTNNB1 PMC3136091__F1 Canonical and non-canonical NFKB signalling pathways RELA RELB PMC6328617__F2 CD44v6 engages in colorectal cancer progression HRAS CD44 CXCL12 MMP2 CCL5 PMC5521196__F5 Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function SOX17 LEF1 CTNNB1 PMC3200485__F2 RGS14 at the interface of hippocampal signaling and synaptic plasticity HRAS RIC8A RGS14 CA3 EGF PSD HEL-S-11 PMC6308626__F2 General mechanism of the extracellular signal-regulated kinase (ERK) pathway and key downstream products important in cocaine addiction JUN CDK5 FOS PMC8584463__F7 Substrate Stiffness Drives Epithelial to Mesenchymal Transition and Proliferation through the NEAT1-Wnt/Beta-Catenin Pathway in Liver Cancer TF CD44 APC VEGFA RUNX2 AXIN2 CTNNB1 PMC4791550__F2 Continuous time Bayesian networks identify Prdm1 as a negative regulator of TH17 cell differentiation in humans SOCS1 STAT3 BATF PRDM1 CXCR5 SOCS3 CISH PMC2094118__F1 The HIF1 pathway in normoxia (A) and hypoxia (B) ING4 HIF1A VHL PMC4811429__F6 Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes ADRBK1 HHIP ARRB2 SUFU GSK3B SHH PMC1572165__F3 Schematic drawing that shows the importance of cell-to-cell and cell-to-matrix-interactions in endothelial cell survival IFNG BAX BAD CTNNB1 PMC6404322__F1 Challenges of driving CD30-directed CAR-T cells to the clinic CCL22 CCR4 CCL17 PMC11591759__F2 Tissue-specific effect of the Runx2 transcription factor and its associations with various signaling pathways and target genes IL2RB MPZ MBP DKK1 RUNX2 PMC11663918__F1 Changes in proteins induced in the cytosol of microglia activated by BzATP and lipopolysaccharide (LPS) EGR1 NLRP3 TNFAIP3 TRAF6 TNF MYD88 PMC8465379__F4 An Updated Comprehensive Review on Vitamin A and Carotenoids in Breast Cancer: Mechanisms, Genetics, Assessment, Current Evidence, and Future Clinical Implications BAX EGFR MTOR PMC7002996__F5 KEGG pathway analysis of the p53 signaling pathway regulated by PCA RFWD2 BAX ATR FAS SIAH1 AIFM2 PERP PTEN MYC TSC2 CASP3 ATM PIGS MDM2 CDK4 PMC4038464__F3 Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease ENO2 SLC2A4 ACACA PCK1 HEL-S-5 PC HEL-S-32 MDH2 GCK HEL-S-133P HK2 HEL-S-278 FASN SLC2A2 SLC2A3 LDHB MPC1 MPC2 DECR2 GPD1 MDH1B PCK2 PDHX PGAM1 PGAM2 ALDOB ENO3 FBP2 HEL-S-68p HEL-S-162eP HEL-S-49 FBP1 ENO1 HEL-S-87p PMC10454035__F2 Hedgehog (Hh) signaling pathway, normal and with Gorlin syndrome PTCH2 SUFU PTCH1 SMO GLI3 PMC7226803__F3 Subcellular distribution of FoxO1 driven by nutritive stimuli in white/beige adipocytes IGF1 INSR INS PMC3423785__F2 Functional analysis of the top-scoring network of AE9a dysregulated genes SPTB HEL-S-103 KLF3 KLF7 RNF144B PRKCH ALOX5 MEIS1 APP LPP CCNB1 KLF6 LGALS7B GM2A SORT1 CDKN1A NAB1 NAB2 HBD Nbla10317 AIF1 CEP55 DACH1 PSAP GADD45A NUP210 CYBB PMC7397661__F3 Interrelated regulatory of CircRNA and EMT CDH2 HMGA2 CTNNB1 PMC2862093__F6 Glucagon-like Peptide-1 Receptor (GLP-1R) is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway GLP1R PI3 PDK2 IRS1 PMC4552880__F1 Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis TNC COMP HSPG2 LAMA1 ITGB4 CD36 HMMR THBS2 THBS3 VTN IBSP CHAD TNR ITGAV COL24A1 GP1BB ITGB6 GP1BA GP6 AGRN ITGA2 LAMC2 RELN CD47 COL2A1 CD44 COL27A1 LAMB2 THBS4 LAMA3 PMC6328617__F3 CD44v6 engages in colorectal cancer progression CD44 CXCL12 EGF HGF EGFR CXCR4 CTNNB1 PMC6328617__F4 CD44v6 engages in colorectal cancer progression CD44 HMOX1 FTH1 KEAP1 NQO1 MDM2 PMC4552880__F2 Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis C6 SMAD1 THBS1 SP1 SMAD2 SMAD4 NODAL ARHA BAMBI IFNG RBX1 FST SKP1 PMC3606754__F2 STRING analysis of the relationship between genes CRP TH MSH6 LTA MICA MIF VEGFA MMP11 BTNL2 RETN HLA-G ABO MMP3 PC TPH2 HP HLA-B KDR PMC3606754__F3 NF-AT signaling and leukocyte interactions have been enriched by GeneGo ZAP70 CD40 BCR LAT IL13RA1 IL4 CCR3 ITK HEL-S-11 LCK PMC8165262__F1 Interleukin-27 and Its Diverse Effects on Bacterial Infections EBI3 JAK1 TYK2 PMC3924248__F1 Contribution of MTHFR, MTR and MTHFD1 in the folate metabolic pathway VIT MTHFD1 MTR PMC4315992__F8 Signaling pathways for PDGF-induced proliferation in PSCs STAT3 STAT1 SRC PMC3192752__F5 Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment CYP8B1 BAAT CYP7A1 PMC11450209__F3 Exploring kinase-substrate interactions of proteins using KiNet BAD PINK1 RAF1 EGFR AKT3 RPS6KA1 BRAF MAPK8 MYC PRKAA1 MAPK3 TGFBR1 MAPK14 LATS1 INSR ROCK1 TTK PAK6 KLF10 EEF1A1 SRC EEF1A2 MAPK1 ROCK2 SGK1 PTPN1 KSR1 IRS1 PAK1 MAP3K7 MAP2K1 MAP2K2 PMC3944239__F8 Working model WEE1 CDT1 ORC1L ARHA PMC7180799__F6 Proposed signaling pathways for the protective effect of LPA against simvastatin-induced cytotoxicity in L6 cells LPA BAD BCL2 MTOR PMC9691847__F6 Baihu renshen decoction ameliorates type 2 diabetes mellitus in rats through affecting gut microbiota enhancing gut permeability and inhibiting TLR4/NFKB-mediated inflammatory response TLR4 TNF IL1B MYD88 PMC3337844__F1 Autophagic proteins FAS FADD PMC8820459__F1 p38MAPK Signaling Pathway in Osteoarthritis: Pathological and Therapeutic Aspects MAX ATF2 PMC9458461__F6 Nuclear DNA damage response by mitochondrial morphofunctional pathway BRCA1 MFN1 MFN2 ATM PMC7791134__F3 Distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells HEL164 TRH UBE2C BUB1B HMMR BIRC5 COL1A1 TACR1 CCNB1 ZCCHC12 ERCC6L CDCA2 CDC2 RAMP3 CHRM5 KIF11 PDE11A GNG4 NUF2 ECT2 MAK PRND RRM2 KNTC2 ECEL1 ADAM33 TACR3 ESCO2 TRHR TMIE FNDC1 TMEM215 SPC25 AURKB CEP55 AVP PMC6137129__F8 Visualization of KEGG IL17 signaling pathway genes differentially perturbed (FDR < 0.05) in rat muscle infected with A TH BOLL GNE LIF TAB3 ELL LCN2 TRAF6 TRAF2 FADD PMC6122050__F1 Tyrosine metabolic pathway – highlighting the site of the enzyme defect observed in alkaptonuria and type 1 hereditary tyrosinaemia and the site of action of nitisinone TRH PNMT DBH PMC6090502__F9 Model for NG2 ICD-mediated intracellular signaling in OPCs EEF2K EIF4B PC EEF2 MTOR PMC11079285__F3 TREM2 mediated immunosuppression and regulation of cancer progression TREM2 GSK3B CTNNB1 PMC6587274__F5 Summary of STAT3-FOXL2 signaling function in HeLa cell growth and apoptosis STAT3 FOXL2 GNRHR TNF PMC7792759__F3 TGFB signalling pathway in breast cancer cells HOXB7 SMAD2 SMAD4 PMC5043614__F1 Molecular subclassification of triple-negative breast cancer (TNBC) based on gene expression profiling CDC42 BRCA1 PTEN GRB2 MTOR SRC PMC5043614__F2 Links between altered glucose and phosphatidylcholine metabolism in breast cancer LPL FAS EGFR MTOR PMC11450209__F4 Exploring kinase-substrate interactions in functional contexts, such as pathways and shared domains using KiNet PRKD3 TH PRKD2 CAMK1 PKN1 SPR PRKD1 EGFR DHFR GSK3B PAK4 PRKAA1 MAPK3 HDAC3 TPH1 CAMK2A HIPK2 PTS SIK2 HDAC5 CSNK2A1 TPH2 CAMK4 PAH SRC HDAC2 HDAC6 MAPK1 LRRK2 MAPKAPK2 MAPKAPK5 HDAC1 CDK5 CAMK2D AURKB PRKAA2 HDAC8 HDAC9 MAP3K7 HDAC7 RPS6KA3 RPS6KA5 CAMK2G PRKG1 PMC5670149__F1 Wnt/Beta-Catenin Signaling SMAD2 APC LRP5 SMAD4 HEL-S-28 LRP6 CTNNB1 PMC11079285__F2 TREM2, as an oncogene, promotes the progression of PTC, GC, PRAD, RCC, EAC, and BCC by activating the PI3K/Akt, NFKB, and JAK/STAT3 signaling pathways, respectively STAT3 TREM2 SYK GC PMC4516462__F2 Transcriptional modifications of DNA repair by UPS in response to cellular stressing conditions BARD1 LIG1 MPG BRCA1 POLE PMC1896004__F4 Signaling pathways downstream of the Toll/TLRs ECSIT TRAF6 MYD88 PMC4516462__F3 Transcriptional activation of DNA repair mediated by UPS-dependent pathways DDB2 RAD51 MSH2 MPG PMS2 PCNA BRCA1 PML MDM2 FANCC MGMT XPC PMC9297598__F11 Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages STAT3 KLF6 MSC ARG1 CCL4 TNF PMC6374299__F2 MDSC-dependent promotion of PMN formation and evolution CXCL12 HMGB1 TLR4 S100A8 ARG1 MMP9 CXCR4 PMC8395144__F1 An Update on the Role of Nrf2 in Respiratory Disease: Molecular Mechanisms and Therapeutic Approaches KEAP1 GCLM NQO1 GCLC PMC9273597__F1 STING cg16983159 methylation: a key factor for glioblastoma immunosuppression CGAS IRF3 CXCL10 PMC7961553__F8 AIM2 function in microglia as a negative regulator of EAE CGAS AKT3 AIM2 IRF3 PMC7374198__F4 General overview of the lipid metabolism in Malassezia, based on lipidomic and in silico genomic analysis presented in and FAS PC FAT1 PMC4756744__F1 AVP-dependent signaling pathways in myogenic cells GATA4 AVP PMC9280743__F7 Mechanism and therapeutic strategy of hepatic TM6SF2-deficient non-alcoholic fatty liver diseases via in vivo and in vitro experiments TM6SF2 FASN CPT1A PMC7244374__F1 Vitamin A uptake, transport, and metabolism SCARB1 LRAT HEL111 RBP4 PMC3590201__F2 Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations LTBP1 IFNG FST SMAD6 SMAD4 SKP1 NODAL ARHA PITX2 PMC3590201__F3 Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations CAV2 BCR MCU PMC3523093__F1 Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches BAX EGF JUND BAD JUNB ATF2 TNF IRS1 PMC9271392__F5 Importance of Sclerostin as Bone-Muscle Mediator Crosstalk APC LRP5 MYF5 LRP6 CS CTNNB1 PMC9271392__F6 Importance of Sclerostin as Bone-Muscle Mediator Crosstalk SMAD2 APC MYF5 CS CTNNB1 PMC9271392__F3 Importance of Sclerostin as Bone-Muscle Mediator Crosstalk APC LRP5 LRP6 CS CTNNB1 PMC6723230__F2 Representative miRNA-gene network interactions between the genes with an altered expression levels when comparing tumor to normal tissue and their respective miRNAs, generated using miRNet HHIP SCD PERP RRM2 SDC4 SFN BBC3 IL6 SDC1 PMAIP1 CD44 DDB2 AGRN IGF1 CDKN1A PTCH2 CCND2 BMP2 BCL2 WNT4 GAS1 CCND1 SDC3 GLI3 PMC12238274__F3 Possible mechanisms of ApoE4 in microglial immune activation TREM2 HMGB1 NLRP3 GLS CD36 TLR4 MTOR LILRB3 TNF NOX4 TRAF2 MYD88 PMC4558214__F1 Soluble recombinant molecule consisting of the extracellular domains of CD80 linked to the Fc domain of Ig (soluble CD80 or CD80-Fc) has the potential to maintain and facilitate T cell activation through three independent mechanisms CD80 APC CTLA4 PMC4628649__F2 Proposed model of the role of TOX in innate lymphoid cell development TF ID2 IL7R TOX NFIL3 PMC12238274__F1 Possible mechanisms by which ApoE4 affects AB production and clearance TREM2 IDE CDK5 BACE1 APP MTOR PMC11896656__F1 Interferon-driven Metabolic Reprogramming and Tumor Microenvironment Remodeling TBK1 IFNGR1 CGAS STAT2 IRF3 IFI16 IRF7 MTOR STAT1 IFNGR2 TLR3 IFNAR2 IFNAR1 JAK1 TYK2 PMC12238274__F2 Possible mechanisms by which ApoE4 affects tau phosphorylation and clearance TF CDK5 PPP2R5E PMC3382204__F5 Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease LTA FAS TGFA HGF LEP LTBR OSM IL3RA IL21R CCR3 CSF3 CSF3R IL-21 MPL CCL23 VEGFB INHBB INHBA INHBE FLT4 CCR6 IL2 TPO CSF2 LEPR LIF KIT IL6 TNF LTB TSLP IL24 BMP2 CCR4 EDAR TNLG7C PMC3073781__F6 Schematic overview of the MDM2 and p53 signalling pathway BAX MDM2 MYC PMC3382204__F6 Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease CD40 CD2 CD36 IL3 CD7 CD14 CD22 EPO CD19 TNF CD34 CD44 CD24 EPOR CD37 CD9 CD33 IL2 TPO PMC3382204__F7 Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease VWF C6 CD59 CPB2 HEL-S-62p F5 PLAUR PLG CR2 CS PLAT F2R TFPI C2 F2 F10 F3 PROS1 C9 THBD A2M F8 F9 PROC PMC7988715__F2 EZH2 overexpression in prostate cancer TMPRSS2 EZH2 ERG MYC PMC5644641__F1 Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway EGF EGFR GRB2 PMC11509156__F3 Metabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compounds GC PMC11749514__F5 Role of the key gene set in the signaling pathway in PI3K-AKT SYK BAD IRF9 RBL2 PTEN CD19 MTOR RAC1 IRS1 RHEB GFAP BCR CD37 MDM2 PMC4381970__F3 Biological activities of TACI ICOS FAS TLR4 BCL6 MYD88 PMC3763651__F1 Schematic presentation depicting the regulation of receptor signaling through G-proteins STAT3 ARHA SRC PMC4744895__F1 Schematic diagram of potential mild freezing shock signaling pathways in barley CBL PC PMC6523340__F4 Simplified biosynthetic pathway of lignin and flavonols CAD ACD PMC3729625__F2 Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling RHEB ATG10 TSC2 ATG3 TSC1 ATG12 ULK1 ATG5 PMC3729625__F3 Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling ATG12 HEL-S-162eP TIGAR PMC4577901__F3 Signaling network of genes that are strongly upregulated following MARV challenge of NHPs SAA1 JUN FOXL2 IRF3 CXCL2 CEBPB CREB1 FOS NFKBIZ PMC3729625__F5 Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling HEL-S-44 PMC3444692__F2 ATF-2 is a nuclear target of p38/Jun N-terminal protein kinase (JNK) SMAD1 SMAD4 ATM ATF2 IL1B PMC4887869__F4 Hydrogen sulfide metabolite trimethylsulfonium is found in human urine RHD HEL-S-64p PMC5349796__F7 E2 and CTNNB1 signals in the oviductal ciliated and secretory epithelial cells regulating embryo transport KIF9 FOXJ1 NR3A2 CTNNB1 PMC7330432__F10 MicroRNA-4500 Inhibits Migration, Invasion, and Angiogenesis of Breast Cancer Cells via RRM2-Dependent MAPK Signaling Pathway PCNA RRM2 PMC1894978__F5 The secretory pathway under different ER stress conditions (t-PA secretion, tunicamycin and DTT) together with examples of genes that are transcriptionally induced or repressed SEC63 DPM2 SELL RFT1 USO1 ALG2 HEL103 ALG3 MNS1 GAS1 PMC7426153__F5 Microbial Strategies for Survival in the Glass Sponge Vazella pourtalesii ASPH FES GIP ACD FAP CIT PMC3823597__F7 Hypoxia-Induced Changes in the Bioactivity of Cytotrophoblast-Derived Exosomes MPL FSTL3 HSPG2 ANXA2 TNF PMC8931781__F1 Biological Activity of 3-O-Acetyl-11-keto-Beta-Boswellic Acid in Nervous System Diseases KEAP1 TLR4 GADD45A IL1B PMC5981095__F3 General schematic diagram of molecular events that regulate proliferation, differentiation and the initiation of migration in the SVZ CDC42 CDK5 FYN SOX1 SOX2 EPHA4 PAX6 HES1 CTNNB1 PMC5981095__F5 General schematic of terminal translocation and differentiation in the CP during development CDH2 VLDLR EPHA4 ROBO1 SATB1 FOXG1 CTNNB1 TBR1 CUX2 CRK DAB1 RAPGEF2 NECTIN3 NECTIN1 SRC CP PMC11770092__F9 Hypothetical model RBM4 RELB PMC8100301__F6 Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19 BAD FABP2 EDNRA CASP3 PTGS2 PMC5534294__F5 Signaling pathways underlying podocyte injury in DN ROCK1 GPR78 RHO CTNNB1 PMC9229059__F1 Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach NPPC RGS2 PLN PDE2A BAD ATP2B1 CALML6 VASP CREB3 RAF1 PPIF MYH6 AKT3 PPP3CA INS MYLK4 PRKCE INSR ROCK1 PDE3A ATP1B4 KNG1 CACNA1C SLC8A2 ARHA IRS1 CD44 NPPA PLCB1 OPRD1 GNA11 NPR2 ADRB1 ADCY1 MAP2K1 GATA4 MRM1 TRPC6 NPPB GNA13 PMC7017417__F1 Scheme summarizing transient receptor potential canonical (TRPC) channel isoforms dysregulated under myocardial infarction (MI) and ischemia and reperfusion TRPC7 TRPC4 TRPC1 TRPC6 TRPC3 PMC5685775__F2 Interactions between TGFB1, canonical WNT/Beta-catenin pathway and PPAR G in radiation-induced fibrosis DKFZp781O1323 SMAD2 APC LRP5 SMAD4 LRP6 CTNNB1 PMC7211126__F1 Schematic depiction of PD-related genes associated with different autophagy pathways VPS35 PINK1 LRRK2 HEL-S-67p FBXO7 PARK2 SNCA VPS13C PMC5685775__F4 Interactions between TGFB1, canonical WNT/Beta-catenin pathway and PPAR G in radiation-induced fibrosis GSK3B PTEN CTNNB1 PMC4926487__F3 Schematic representation of the DNA repair system for neuroprotection implying that genome stability is sustained on several tumor suppressors BRCA1 ATM PTEN PMC12189591__F2 Biosynthesis pathway of SFA and MUFA with graph data of fatty acid composition in the plasma of the control and atherosclerosis (AS) group FADS2 ELOVL1 ELOVL5 ELOVL6 FADS1 PMC5290251__F1 Nucleotide‐binding oligomerization domain (NOD)‐like receptor (NLR) pro‐inflammatory signalling pathway CARD8 ERBIN CAD NLRP3 TNFAIP3 TAB3 NOD2 NOD1 HEL-S-276 PMC5723018__F9 FKBP11 affects the formation and progression of AAD FKBP11 VCAM1 MMP9 IL1B PMC12215251__F1 Wnt/Ca2+ signaling pathway, created in BioRender CDC42 ORAI1 STIM1 NLK CTNNB1 PMC3342110__F1 Signaling pathways important for C INS PMC3493873__F1 TP53 mutation status-specific network of potential candidate driver genes shown based on their known and predicted functional interactions SOCS1 UBE2C EGFR HIF1A IGF1R CCNA2 PLK1 GTSE1 RARA CA12 BTRC ARNT2 MAP2K4 ADCY9 CCNE1 CCNB1 CCND1 ERBB4 VEGFA IRS1 ERBB3 PTTG1 CHEK1 BCL2 ADCY1 GLI3 PMC6660170__F1 Nanoparticle-mediated autophagy ATG12 MTOR ATG5 PMC3565579__F1 Proposed mechanism for opioid modulation for TLR TBK1 TLR1 TLR3 TIRAP TLR4 IRF3 LBP PMC6262497__F4 JAK-STAT signaling pathway after treatment with N4-Eru SYK RAF1 JAK3 IL2RA GRB2 LCK PMC6262497__F3 Notch signaling pathway after treatment with N4-Eru NUMB HES1 HES5 PMC3955168__F3 The unfolded protein response (UPR) pathway and its chemical modulators ATF4 EIF2A XBP1 PMC7002394__F10 Insulin signaling cascade targeted by WEE in PA treated HepG2 cells PDK4 DHRS9 RBP1 IRS1 PMC6258353__F3 Proposed biosynthetic pathway for TNL A (1) supported by the isolation of congeners or shunt metabolites 4–11, as indicated by the dashed arrows IPP TNIP2 TNIP3 PMC7306689__F7 Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3 CBL FGFR1 UBE2D3 PMC7864817__F1 Metabolic changes induced by DOXO in cardiomyocytes ULK1 BCL2 MTOR IRS1 PMC11769378__F3 Activation of TLR2 signaling pathway by bacterial lipoproteins (BLPs) TIRAP TRAF6 TNF MYD88 PMC6124166__F1 Schematic model demonstrating how PTH signaling leads to changes in SOST and RANKL expression in osteocytes TH SOST SIK2 CRTC2 HDAC5 PTH MEF2C PMC9386877__F1 Taste transduction and channel synapses in taste buds TRPM5 OTOP1 CALHM3 CALHM1 PMC9523695__F6 Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway FAS ATM MTOR PMC6643215__F9 Schematic diagram summarizing the anti-NSCLC action of butein via activation of ER stress and ROS generation BAX BCL2 ATF4 EIF2A XBP1 PMC10474147__F14 Mechanism underlying oxeiptosis KEAP1 PGAM5 AIFM1 PMC7600656__F5 Hepcidin expression via bone morphogenic protein (BMP)-SMAD signaling pathway in hepatocytes SMAD1 TFRC TFR2 DKFZp781O1323 SMAD4 HFE TMPRSS6 PMC3418550__F1 Pathways of SMX metabolism, bio-activation and detoxification, and pathway of GSH biosynthesis NAT2 HEL-S-64p NAT1 MPO PMC6721670__F5 Canonical pathways linked to hNgb binders in a non-stress condition TEC ELF4 RHO PMC6721670__F6 Upstream regulators and signaling cascades linked to the hNgb protein interactors in a non-stress condition ACHE NME3 MYB HEL113 REST EWSR1 EGFR HEL-S-89n ID1 FGF2 HEL-117 CDKN2A PRKCE NGB APP SHC3 YWHAZ PMC3589124__F7 FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage BAX HIPK2 FOXO3A ATM PMC4821380__F1 EGFR and IGF1R signaling pathways.Notes: Binding of extracellular ligands results in autophosphorylation of key tyrosine residues in the C-terminal domain of EGFR, which allows downstream proteins to bind through their Src homology 2 (SH2) domains TSC2 TSC1 EGFR PTEN IGF1R GRB2 MTOR IRS1 PMC4859809__F1 MicroRNA biogenesis pathways in cancer AGO4 DGCR8 AGO1 XPO5 AGO2 DICER1 DROSHA PMC4859809__F2 MicroRNA biogenesis pathways in cancer ATF3 DGCR8 DICER1 ATF1 ATF4 IL1A ATF2 DROSHA PMC11825590__F4 Portion of the canonical NFKB signaling pathway containing IRAK1 and inflammatory cytokines discussed in this study (IL-1beta, IL-6, and IL-8) MAP3K7IP1 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC5817867__F2 RTK-regulated signaling in breast cancer progression STARD13 EGFR SOX2 ERBB2 NODAL MYC TWIST1 PMC8623831__F4 Treatment of HT29 Human Colorectal Cancer Cell Line with Nanocarrier-Encapsulated Camptothecin Reveals Histone Modifier Genes in the Wnt Signaling Pathway as Important Molecular Cues for Colon Cancer Targeting TMEM97 SMAD4 SETD2 ROCK1 CCND1 CDK4 MMP7 CITED2 FEN1 DKC1 USP34 AFF4 APC MYO6 RPS27A YBX1 RPL21 SCAF11 SDC1 USP9X KITLG SFRP1 ZFYVE16 FKBP4 TNRC6B MCM3 MAP3K7 PMC7072884__F1 Schematic display of G-protein-coupled receptors (GPCRs) signalling in cognitive impairment BLK CASP9 BIK PMC3509892__F1 Transcriptional Changes Associated with Lack of Lipid Synthesis in Parasitoids FAS DLAT SCD PC CS PMC6745947__F1 Hepcidin regulation by iron and erythropoiesis TF ERFE BMP6 SMAD1 TFR2 BMP2 EPO HFE TMPRSS6 HFE2 PMC10903154__F4 Hippo pathway dysregulation from pancreas precursor lesions to malignancy STAT3 PAF1 ADM SOX9 PMC7811960__F2 Azithromycin effects in the pathophysiology of COVID-19 after receptor-mediated endocytosis, both viral (PAMP) and host released (DAMP) molecules trigger antiviral pathways TF IFNG IL10 APC IL4 POLI IL2 IL6 CXCL10 ACE2 IL1B PMC10903154__F1 Hippo signaling pathway and its network LATS1 MOB1A MOBKL1A LATS2 NF2 AREG MYC RUNX2 PMC9371685__F4 Sulfur and methane oxidation by a single microorganism NHS C2 CYC1 ACD RHO PMC3746082__F3 Diabetes mellitus induced regulation of osteoclast SYK GC CCR2 MTOR SRC TRAF6 TNF IL6R PMC3779868__F1 Phosphoinositide signaling and its regulation by phosphatases INPP4A INPP4B PI3 ITK PTEN PMC3746082__F1 Diabetes mellitus induced regulation of osteoblast HTR2B SOST TWSG1 MGP PTH GRB2 TNF RUNX2 PMC3746082__F4 Diabetes mellitus induced regulation of skeletal muscle CDC42 IGF1 GC MTOR EIF2A TNF RAC1 PMC4902960__F6 Activation of NFKB and STATs signaling pathway in ZIKV-infected hNPCs CD40 STAT3 CXCL12 STAT2 IRF9 TLR9 IRF3 TRAF3 TRAF6 MYD88 STAT1 TLR3 TLR8 STAT4 TLR7 CXCR4 TRAF2 PMC8863963__F14 Comprehensive Analysis of the Expression and Prognosis for ITGBs: Identification of ITGB5 as a Biomarker of Poor Prognosis and Correlated with Immune Infiltrates in Gastric Cancer HEL-S-99n RILP LOX CD36 TLR4 VAMP3 STX7 CD14 MARCO TUBB PIKFYVE MPO PMC3549317__F1 Lipid synthesis in yeast HEL-S-5 PC PMC8863963__F11 Comprehensive Analysis of the Expression and Prognosis for ITGBs: Identification of ITGB5 as a Biomarker of Poor Prognosis and Correlated with Immune Infiltrates in Gastric Cancer SYK BAD VASP HEL-S-28 RBL2 CYC1 PTEN CD19 RHO SHE RAC1 CRK BOLL FYN BCR CD37 RXRA MEI1 TOX GRB2 PMC4080186__F1 Rho GTPase signaling pathway represents a convergent approach to targeting fibrosis LPA RHO PMC6981023__F6 Graphic summary of the regulation of memory T cell response by mTOR and Stat3 STAT3 HIF1A SOCS3 BCL6 PMC5795459__F1 Canonical type I and III IFN signaling STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 IL10RB PMC9572342__F9 Fermentation Extract of Naringenin Increases the Expression of Estrogenic Receptor B and Modulates Genes Related to the p53 Signalling Pathway, miR-200c and miR-141 in Human Colon Cancer Cells Exposed to BPA TP73 BAX RPRM PTEN APAF1 PMC7313026__F2 RNF186, RNF182, and RNF152 are involved in the regulation of the mTORC1 pathway RHEB EGF USP4 EGFR SHH RNF182 FOXA2 RNF186 RNF152 PMC8647434__F1 Targeting Lymphangiogenesis and Lymph Node Metastasis in Liver Cancer PROX1 PDGFD VEGFC HIF1A VEGFA PMC8486873__F2 ER stress regulate the secretion of EVs which contained immunomodulatory factors HMGB1 IL10 TLR4 APC PTEN PMC8486873__F3 DNA damage stress induced the release of immunomodulatory cargoes through EVs CGAS IRF3 IL1B PMC3970768__F1 The biotin cycle and the known and putative roles MCC PC PMC7974027__F7 Schematic depicting possiblem echanisms governing the pro-tumorigenesis effect of NET and miR181a targets in the PGRMC1/EGFR–PI3K/Akt/mTOR signaling pathway in breastepithelialMCF10Acells CASP9 PCNA EGFR BCL2 PTEN PGRMC1 MTOR CCND1 PMC2728746__F7 Proposed model for the mitogen-activated protein kinase kinase 4 (MEK4) regulation of human prostate cell motility and for its inhibition by genistein ENG SMAD1 MAPKAPK2 PMC5336551__F2 Chronic lymphocytic leukaemia CHD2 RPS15 CD79B SYK BCOR CD79A SF3B1 XPO4 DYRK1A FUBP1 CARD11 BRAF CD22 TRAF3 MYC CTNNB1 MYD88 MGA GNB1 ELF4 MED12 FBXW7 BCR TLR8 RIPK1 ATM POT1 IKZF3 BIRC3 EWSR1 LRP5 CD14 ASXL1 PTPN11 CD19 IRF4 KRAS LYN MAP2K1 EGR2 DDX3X TRAF2 BRCC3 PMC6335096__F4 Peroxisome biogenesis PEX7 PEX19 PEX6 PEX5 GET3 PMC6335096__F5 Three mechanisms of pexophagy in mammalian cells RHEB NBR1 TSC2 TSC1 ULK1 PEX6 PEX5 ATM PEX2 PEX10 PEX12 PEX26 PMC4546491__F2 Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics GNAS DVL1 SALL4 FGFR1 NTRK1 SOX2 PMC6160397__F5 Proposed model for PD-L1 induction in CC WNK2 SOX6 PTEN CTNNB1 PMC4095565__F2 NOD1 and NOD2 signaling cascades MAP3K7IP1 ATG16L1 ATG12 TAB3 TRAF5 NOD2 NOD1 TRAF6 ATG5 TRAF2 UNK PMC7677640__F1 Mechanism of immune rejection caused by major histocompatibility complex (MHC) mismatch IFNG TH APC FOXP3 PMC9306018__F1 Diminishing Returns of Mechanical Loading and Potential Mechanisms that Desensitize Osteocytes SOST LRP5 LRP6 ARHA CTNNB1 PMC6008220__F3 Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes IFNG TH CS PMC6705132__F7 Schematic model for BA-TPQ-induced MCF7 cell apoptosis ATF3 JUN DDIT3 PMC4985172__F2 Intracellular signaling pathways of EET’s STAT3 EGF SRC PMC6103459__F1 Cell cycle proteins mediating progression during MI SPC25 SMC1B MCC APC KNTC2 SPC24 ESCO2 PMC7573295__F1 UCA1 can enhance expression of AKT1 and activate it through phosphorylation STAT3 HK2 MTOR PMC5133678__F7 RBM5 targets in the EGFR Signaling pathway CDC42 BAD RAF1 SHC1 SOS1 MAPK3 CRB2 PHLPP1 FOXO4 ADAM17 PDE1C PHLPP2 PDE1B PDPK1 CLTA AP2A1 PRKCA AP2A2 NRAS ADAM12 HEL-S-1 CAMK4 PRKAR1A TRIB3 CREB1 SPRY1 MAPK1 CDC2 CASP9 MAK PTPN11 KRAS HRAS SPRY2 TSC2 GSK3A PDE1A CDKN1A FOXO1 PRKACG FOXO3A CSK CALM1 ADAM10 JAK1 MAP2K1 PMC5260980__F4 Signaling pathways at the crossroad between autophagy and EMT STAT3 DEDD MTOR SRC RUNX2 EIF2AK2 PMC3901523__F3 Signaling pathways for inner ear proliferation and differentiation NEUROD1 CDKN1A ATOH1 CDKN1B NEUROG1 CDKN2D HES1 PMC5260980__F2 Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer JUP EGF TNC HEL113 ZEB2 PMC8522258__F4 Synergistic metabolic pathways that lead to a hyaluronan storm, NETosis, coagulopathy, and immune suppression STAT3 STAT1 EGFR HAS2 SIRT1 PMC2661888__F3 Hypergraph representation of the Boolean model for yeast glucose repression CATIP GAL PCK1 PMC8388496__F4 Comprehensive Transcriptomic Comparison between Porcine CD8− and CD8+ Gamma Delta T Cells Revealed Distinct Immune Phenotype CXCR3 CD79B SYK FAS CSF1 MAPK13 VAV2 CD27 PIK3R1 TEC IFNG CX3CR1 GHR CCL3L3 TNFRSF11A CXCR6 CCL16 NCK1 TNFRSF9 CD8B1 TNFSF6 XCL1 PIK3AP1 CD19 CD40LG TNF ICOS NFKBIA CD8A LCK PMC2880865__F8 Revitalization of a diastemal bud SPRY2 FGF7A SHH FGF5C FGF10 PMC2895370__F1 TLR4 signaling: The MyD88-dependent pathway through PDCD4 TLR4 MYD88 PMC4597143__F4 Quantification of the full chemotaxis pathway PIK3CA PXN PIK3R1 PRKCZ MAPK8 DOCK2 DOK1 EZR FYN CFI PDPK1 PRKCA WAS PC ITK TMSB4X SRC PIKFYVE MAPK1 APC INPP5D HEL-S-28 PTK2B NCKAP1 PID1 DOCK1 BRK1 HEL114 ARHGAP5 CRK PREX1 CAPNS1 RGS6 PARD3 MAP3K1 ELMO1 RAPGEF1 ARHGEF4 ARHGEF1 CSK ARHGEF7 WASF1 WASF2 GRB2 BAIAP2 ARHGAP24 GNA13 OPN1SW CDC42 ABI2 RGS2 RGS12 FERMT3 BAD GNAO1 PIK3R5 ZYX BRAF PTEN NCF1 CTNNB1 MYLK MAP2K4 S1PR2 RGS1 ARHGEF2 JUN ARHA S1PR1 FOXO3A NFKB1 RELA RPS6KA3 MAP2K1 PMC3662220__F1 Novel zebrafish model reveals a critical role for mapk in lymphangiogenesis TSC2 TSC1 GRB2 PMC9498168__F8 MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway KLF2 SCN8A GRIA2 DSCC1 HMGA2 ELAVL4 THY1 CACNG8 GLRA2 CLSPN NR4A3 E2F7 GABBR2 CDKN2B CCNA2 GRID2 UNC13A GINS4 CKAP2 OPRK1 STAT1 SHISA9 SHCBP1 DEPDC1B CDK6 LIN28A DNA2 LEFTY1 FOXC1 KRT5 XPO5 CADM2 IGF2BP3 PRDM1 CADPS RBFOX1 IL1A FOS RBL1 MAPK10 PMC7456945__F6 Simplified metabolic network indicating major pathways of volatile organic compound (VOC) synthesis and associated CO2 decarboxylation processes in the light IPP LOX PDC PMC7595122__F1 Caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer BAX CASP9 GSDMD CASP5 CASP4 CASP3 DFNA5 IL1B FADD PMC9534090__F4 Emergence and dissemination of monkeypox, an intimidating global public health problem IFNG SYK IRF9 APC IRF3 TRAF3 EIF2A TRAF6 PMC7595122__F3 Graphical model of the effect of various molecules on caspase-3 dependent tumor cells death CASP9 CASP3 DFNA5 PMC12179916__F5 Myosin heavy chain 9 activates the Wnt/Beta-catenin signaling pathway to enhance the proliferation and survival of cancer cells MYH9 CTNNB1 PMC11537654__F4 Homoharringtonine (HHT) enhances the proapoptotic effects of venetoclax by inhibiting the MAPK/ERK and PI3K/AKT pathways and activating the p53 pathway (orange line) ATR GSK3B ATM PTEN MDM2 PMC3705993__F1 LRP5, LRP6 and LRP4 are important components of the Wnt/Beta-catenin signaling pathway LRP4 DKK1 HBM LRP6 SFRP1 CTNNB1 PMC8126980__F4 Ferroptosis in infection, inflammation, and immunity STAT3 HMGB1 TBK1 JUN CGAS TGFB1 IKBKE IRAK1 IRF3 IRF7 TRAF3 TNF TRAF6 CCL2 IKBKG MYD88 AGER TICAM1 TLR4 IKBKB NFKBIA CHUK MITA PMC8505885__F1 Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations CD40 STAT3 BCR HEL-S-133P FOXO1 PAX5 F2 HK2 TRAF3 IRF4 MPC2 RRAS2 PMC3081180__F7 The participation of MCP-1, TNFA, MMP-9, E-cadherin, and Beta-catenin in macrophage fusion CCR2 MMP9 TNF PMC9393846__F1 Chromosome instability and aneuploidy as context-dependent activators or inhibitors of antitumor immunity CGAS APC MICA MICB PMC4863308__F1 Hedgehog (Hh) signaling.Notes: Normal activation of the signaling pathway results from the binding of Hh ligand to the 12-transmembrane patched 1 (PTCH1) SUFU PTCH1 SMO PMC8505885__F2 Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations CD40 STAT3 BCR TLR9 AHR HIF1A PMC6113163__F4 Signaling Pathway of Rho Guanine Nucleotide Exchange FactorImportant functions of this pathway involve antiapoptotic actions and regulation of actin-myosin interaction CDC42 PIK3CA PKN1 PIK3CD PIK3R2 WASL IQGAP1 RHO ROCK1 WAS RTKN ARHGDIG HEL-S-15 CIT CFL2 RHPN2 TNK2 MYBPH PFN1 ROCK2 LIMK1 ARHGDIB RPS6KB1 ARHGEF1 MAPK10 PMC11537654__F2 Homoharringtonine (HHT) causes phosphorylated eukaryotic initiation factor 4E (p-eIF4E) to SUMOize more fully SUMO3 LPCAT2 HEL-S-5 CDK2 PTEN ADAM10 PLA2G2D MTOR EIF4E TRIM21 PMC3446326__F1 Alterations in the FGFR signalling pathway that influence breast cancer FGFR4 FGFR1 FGFR2 PMC11537654__F3 Combination of homoharringtonine (HHT) and quizartinib inhibits the FLT3-AKT signaling pathway and its downstream targets (purple line) FLT3 BAX MTOR PMC11537654__F1 Homoharringtonine (HHT) directly binds the nuclear factor-kappa B (NF-KB) repression factor (NKRF) through the second double-strand RNA-binding motif (DSRM2), a nuclear localization signal for NKRF FLT3 TSC2 TSC1 SP1 MAP4K1 C2 HOXA9 TET1 MEIS1 PTEN MTOR MYC PMC7339185__F12 Regulation mechanism of miR‐128‐3p in BCSCs CD44 CD24 EGFR PYGO2 NEK2 CXCL16 CTNNB1 PMC4022581__F4 Transcriptome Profiling of the Theca Interna in Transition from Small to Large Antral Ovarian Follicles LTBP1 EPCAM ARNT2 LTBP2 NAT2 FRZB UBC AOX1 KLF6 COL14A1 NTRK2 IL20RA SLC7A2 TNF IF2G LIPG TSPAN3 STOX1 CD44 TESC NOSIP ATP1B3 XB PLXDC2 EPHX1 CLDN11 APBB1IP WDFY4 PTPRE BCL2 IL10RB PMC9483763__F1 Current Review in Basic Science: Animal Models of Focal Cortical Dysplasia and Epilepsy RHEB TSC2 TSC1 NPRL2 C16orf35 PTEN DEPDC5 PMC4041457__F4 The SDSA (synthesis-dependent strand annealing) and DSB repair sub-pathways GEN1 RTEL1 BLM SLX4 EME1 RMI1 PMC6349324__F1 Role of tumor-associated neutrophils in regulation of tumor growth in lung cancer development: A mathematical model EGF MYC PMC8607427__F2 Post-translational modifications of CDK5 and their biological roles in cancer EGR1 CDK5 PMC8607427__F3 Post-translational modifications of CDK5 and their biological roles in cancer PDPN STAT3 BAX CDK5 H2AX EGFR BIN1 CDK2 ATM EZH2 HCTP4 EME1 PMC6743755__F3 Petri net–based model of the human DNA base excision repair pathway PNKP FEN1 PCNA INS PMC6810723__F4 Network structure of the 66 genes (left figure) and the top 12 selected genes listed in (right figure) from KEGG “Drug metabolism-cytochrome P450” pathway, extracted using the R package KEGGgraph UGT1A1 CYP1A2 MGST3 FMO5 CYP2A6 AOX1 UGT1A9 UGT1A5 CYP2E1 CYP2B6 CYP2C19 MGST2 CYP3A4 PMC3563076__F2 Molecules involved during pancreatic development FOXA1 PDX1 SOX9 PAX4 MAFA PTF1A OCEL1 ECEL1 NEUROG3 FOXA2 POU3F4 FGF2 PMC7602498__F1 Homocysteine (Hcy) metabolic pathway VIT PMC4900455__F2 Reciprocal antagonism by TLR4 oncogenic and TGFB tumor suppressor pathways STAT3 IGF2BP3 YAP1 PMC5962335__F4 Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration PNP NRK NAPRT HEL-S-90n NAMPT PMC3947295__F1 Scheme of the metabolic pathway of n-6 and n-3 long-chain polyunsaturated fatty acids ELOVL2 GLA FADS2 ELOVL5 FADS1 PMC8715940__F6 Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes GRIN2B PIK3CA BAD PIK3CD GSK3B CHRM3 MTOR PSEN1 CTSC ERN1 CDK5R1 PDPK1 CHUK CSNK2A1 NOS2 JUN CTSL CTSK PTGS2 TNF CAMK2D PSEN2 IKBKB CASP3 MAP3K5 BIRC2 PMC9482625__F3 Cellular composition within the TME and the effect of EMT on TKI resistance EREG HGF TGFA AXL CCL15 SMAD2 SMAD4 ZEB2 CCL2 TWIST1 CTNNB1 PMC8715940__F7 Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes DVL1 PIK3CA PIK3CD CYCS GSK3B CHRM3 PPP3CA PSEN1 MAPK8 MAPK3 CDK5R1 RYR3 FRAT1 PSENEN MME CSNK1E APH1B DKK1 CSNK2A1 WNT1 CSNK1A1 EIF2AK2 MAPK1 CASP9 NOS2 FZD2 APC LRP6 TNF IRS1 HRAS PSEN2 AXIN1 CALM1 GRIN2B BAD TNFRSF1A BACE1 MTOR INS CTNNB1 EIF2S1 ADAM17 INSR CHUK ATF4 PTGS2 ARAF AGER NFKB1 CASP3 MAP2K1 TRAF2 PMC6715281__F1 Wnt signaling pathways and the regulation by Wnt antagonists and the bone microenvironment SOST APC ROR2 LRP5 LRP6 RYK HIF1A UNK VHL PMC9393259__F1 Underlying pathological mechanism of ferroptosis in the development of cardiovascular disease GPX4 SLC7A11 HEL-75 PMC9482625__F4 Impact of tumor metabolic reprogramming on TKI drug resistance FH HGF SP1 PHGDH CD36 EGFR FASN PTEN HEL-S-30 PMC8715940__F5 Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes STAT3 GRIN2B PIK3CA JUN BAD AXL GSK3B BACE1 NTRK2 PTGS2 MTOR PSEN1 CDK5R1 MME INSR CX3CR1 CHRNB2 PDPK1 CASP3 MAP3K5 PMC11955630__F9 Pathway analysis for CKS1B and related genes FLT3 STK11 RAF1 SOS1 EGFR AKT3 BRAF PTEN IGF1R FGFR2 CDKN2A ALK NF1 ERRFI1 FGFR1 CHEK2 RIT1 NRAS ATM MDM2 RPTOR ROS1 ERBB4 NTRK2 PTPN11 KIT KRAS RAC1 ARAF HRAS RHEB TSC2 CBL RICTOR TSC1 PDGFRA NTRK1 ERBB2 FGFR3 RPS6KA3 MAP2K1 MAP2K2 RET PMC8170402__F2 Molecular Mechanisms of Specific Cellular DNA Damage Response and Repair Induced by the Mixed Radiation Field During Boron Neutron Capture Therapy RAD51 BRCA1 BRCA2 ATM XRCC3 PMC3081924__F10 Model for SENP2-mediated modulation of Mdm2 in regulating p53 PML SENP2 MDM2 PMC7744508__F1 Central carbon metabolism network, which was implemented in the multi-level kinetic model of Synechocystis HEL107 HPR GCA TNLG7C PMC9393259__F2 Underlying pathological mechanism of ferroptosis in the development of cardiovascular disease TLR4 IL1B MYD88 PMC11989024__F3 Cellular signalings and mechanisms of integrin-mediated drug resistance in cancer cells EGFR MTOR SRC PMC6625751__F1 Type I interferon in rheumatic diseases CGAS MAVS STAT2 TLR9 CD14 IRAK1 IRF1 IRF3 IRF7 TNF TRAF6 IRAK4 MYD88 STAT1 TLR3 TLR4 TLR8 TLR7 JAK1 TREX1 TYK2 PMC5649010__F8 Model for atypical MyD88-independent TLR7 signaling during Yersinia pestis infection TLR7 EEA1 MYD88 PMC5449407__F7 SAR signaling in maize inflorescence based on DEG analysis LOX CAD PMC8929255__F4 Immune barriers in haematopoietic stem cell gene therapy IFNG CGAS ATM TNF PMC5153247__F8 Schematic diagram of Akt/Id2 signaling pathway in the neuron CA3 ID2 PMC7729279__F2 Illustration of molecular signaling involved in SARS-CoV-2 infection TMPRSS2 TBK1 CGAS MAVS STAT2 IRF3 IRF7 MYD88 STAT1 IFNAR2 IFNAR1 TLR8 TLR7 ACE2 IL1B PMC12061301__F7 AKT1 regulating cuproptosis in TNBC tumorigenesis DLAT FDX1 PMC8591232__F2 Targeting Macrophage Dysregulation for Viral Infections: Novel Targets for Immunomodulators IFNG STAT3 CXCL1 IL8RB PMC4284697__F1 Summary of the p53 pathway BAX DDB2 MSH2 PML TIGAR SCO2 MDM2 GADD45A SESN2 FANCC PMC9356848__F7 Transmembrane Protein ANTXR1 Regulates Gamma-Globin Expression by Targeting the Wnt/Beta-Catenin Signaling Pathway SOX6 APC CCND1 CTNNB1 PMC5095106__F3 TNFR1-elicited signaling pathways TRADD USP21 TNF CYLD TRAF2 FADD PMC8492288__F2 Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview ID2 AHR TNF ID1 PMC8170847__F2 Developmental Pathway and Interconnectivity of Immunotherapy and Nanotechnology: HEL-S-92n NPS PMC9312905__F7 Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry TG STIM1 TRPC6 PMC8431116__F2 MYC Rules: Leading Glutamine Metabolism toward a Distinct Cancer Cell Phenotype GLS LAT2 GPT PMC5190058__F8 Combination of gemcitabine-containing magnetoliposome and oxaliplatin-containing magnetoliposome in breast cancer treatment: A possible mechanism with potential for clinical application GML BAX PMC8536196__F1 Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review FKBP5 CRHBP SKA2 CRH MC2R PMC7460555__F1 PI3K/Akt/mTOR, ERK1/2-MAPK, and Wnt/Beta-catenin pathways RHEB TSC2 NGF TSC1 APC BACE1 RS1 LRP5 LRP6 PTEN GRB2 BDNF PMC6023907__F3 The BMP signaling cascade in osteoblast differentiation TCF12 SMAD6 SMAD4 RUNX2 TWIST1 MSX2 PMC3757225__F7 Mechanistic model of strain-induced fetal type II cell differentiation via integrin-TACE pathway HBEGF TGFA ADAM17 EGFR PMC6894473__F1 Schematic view of the Wnt signaling pathways between MSCs and HCC cells in inflammation microenvironment IFNG EPCAM APC ELL LRP5 MSC LRP6 TERT CTNNB1 PMC3260150__F2 Identification of a Potential Ovarian Cancer Stem Cell Gene Expression Profile from Advanced Stage Papillary Serous Ovarian Cancer BAD ADAM19 FPGT ST3GAL6 PMC6894473__F2 Schematic view of the TLR4 signaling pathways between MSCs and HCC cells in inflammation microenvironment TIRAP TLR4 MSC TRAF6 LBP MYD88 PMC6894473__F3 Schematic view of the AP-1 and PKB signaling pathways between MSCs and HCC cells in inflammation microenvironment BAD MSC PTEN MTOR TRAF6 PMC7503096__F1 Two common pathways implicated in thyroid cancer TERT PTEN MTOR PMC7699912__F1 Toll-like receptors (TLR)-mediated signaling pathway in keratinocytes TLR1 LTA TLR3 TLR4 TLR9 CD14 TLR5 IRF3 IRF7 PMC2956794__F1 Targeting DNA repair proteins for cancer treatment XPA RAD52 RAD51 LIG1 FEN1 PCNA BRCA1 BRCA2 ATM MGMT XPC PMC8441939__F1 Immune response to SARS‐CoV‐2 in children: A review of the current knowledge STAT2 IRF9 IRF3 PMC5904130__F5 Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist RHEB MTOR BDNF PMC10530696__F1 Deciphering the Enigmatic Influence: Non-Coding RNAs Orchestrating Wnt/Beta-Catenin Signaling Pathway in Tumor Progression SP1 BLACAT1 APC SOX4 CTNNB1 PMC4583389__F3 Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma BTC NRG3 NRG4 PMC8838558__F7 One-Carbon Metabolism in Alzheimer’s Disease and Parkinson’s Disease Brain Tissue HEL-S-61p MTR PMC6317074__F1 Proposed cholesterol-lowering mechanisms of PS ABCG8 ABCG5 ACAT2 NPC1L1 LDLR ABCA1 PMC6834139__F2 ST2/IL-33 immune cells signaling pathway IFNG CSA2 TGFB1 HGF IGF1 IL16 IL33 IRAK1 MYD88 PMC9188347__F1 Metabolites as drivers and targets in rheumatoid arthritis HEL-S-133P HK2 ACOD1 PMC8990477__F2 CAR-T Cell Therapy for Breast Cancer: From Basic Research to Clinical Application BCL2 MTOR MYC PMC8998551__F4 Solid Tumors and Kinase Inhibition: Management and Therapy Efficacy Evolution FLT3 PDGFRA KIT MTOR RET PMC2733795__F4 Regulation of STAT3 signal transduction pathway SOCS1 STAT3 SOCS3 IL6R PMC11544397__F6 ERS induces renal fibrosis in high-fat diet mice via the TGFB/SMAD pathway SMAD2 PMC4276042__F1 Targeting the PI3K pathway for cancer therapy RHEB BAX TSC2 BAD TSC1 GSK3B PTEN ARHA MDM2 CCND1 RAC1 EIF4E PMC9180737__F3 GLIS1-3: Links to Primary Cilium, Reprogramming, Stem Cell Renewal, and Disease STAT3 ARL13B CD133 PMC9180737__F2 GLIS1-3: Links to Primary Cilium, Reprogramming, Stem Cell Renewal, and Disease HEL113 SNAI1 FGFR1 GLIS1 PMC6750892__F11 Proposed mechanism for how AvB3 integrin signaling could be mediating fibronectin matrix assembly in TM cells HEL-S-28 ARHA SRC PMC11054193__F7 DEGs and DMs change following exogenous ABA therapy and UV-B stress in the R DLAT HMGCR MVD FDPS PMC7316593__F8 RSV induces Uric acid and leads to Th2 response HEL-S-92n TSLP IL13 IL33 CCL2 IL1B PMC3493902__F8 The diagram illustrates the possible mechanism of tumor cells-secreted CCN1 in regulation of pancreatic carcinogenesis through the regulation of SHh signaling SHH SMO CCNI PMC8093976__F4 Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases DLL4 SEMA3E PLXND1 RHO RAC1 PMC5751130__F1 Regulation of the TGFB signaling pathway by miRNAs SMAD2 SMAD4 SMURF2 PMC5159651__F7 Suggested model for modulation of Wnt pathway by OCC-1 splice variants APC APC2 APPL2 CTNNB1 PMC11274024__F6 Different cellular events in RG7388-resistant CLL samples BAX FAS TP53INP1 TNFRSF10B PCNA BBC3 AEN XPC TNFRSF10D DRAM1 DDB2 ZMAT3 PHLDA3 CDKN1A MDM2 PMC8093976__F2 Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases SEMA3C NRP1 SEMA3E PLXND1 PMC8093976__F3 Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases SEMA3C SH3BP1 SEMA3D ARF6 NRP1 PLXND1 VEGFA RAC1 PMC8593325__F3 Cleaved PINK1 in Neuronal Development, Synaptogenesis, and Plasticity: Implications for Parkinson’s Disease PINK1 PARL BDNF PMC10454494__F3 Prostate cancer pathways [112] TF BAD MVP PMC5000709__F2 Kallistatin inhibits angiogenesis and inflammation through blocking VEGF signaling and NADPH oxidase activity PDK2 VEGFA SRC RAC1 PMC5000709__F3 Kallistatin inhibits Wnt canonical pathway induced angiogenesis and inflammation CDC42 GSK3B LRP5 LRP6 RAC1 CTNNB1 PMC8437644__F7 Studies on the Role of circRNAs in Osteoarthritis CD36 CHAD CD47 PMC7415495__F6 Molecular mechanisms underlying Beta-cryptoxanthin inhibits A7-nAChR, thereby leading to the inhibition of lung cancer progression and metastasis BAX BAD MMP12 COX2 MMP2 MMP9 PMC4249256__F5 Illustration of the proposed crosstalk between insulin/IGF1 and IL-17 signaling pathways IL17RC IGF1 CXCL1 TRAF6 CCL20 PMC3730126__F1 Molecular mechanisms of cellular insulin resistance in muscle and liver LPL TG DGAT1 UCP3 DGAT2 IRS1 PMC4460810__F1 Wnt/Beta-catenin pathway regulates stem cell pluripotency and cell fate decisions during development CD44 APC MYC CTNNB1 PMC5328691__F1 Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance ELF2 ATF4 XBP1 PMC7415495__F3 Molecular mechanisms underlying Beta-cryptoxanthin prevention of cancer development/progression RARB HEL-S-133P MMP2 MMP9 CCND1 SIRT1 BCO1 PMC2689231__F6 Purine biosynthetic pathway, showing protein abundance changes for the P PURA ADK PURB PMC7162828__F1 Kynurenine pathway of tryptophan degradation HEL-S-90n KYNU AFMID PMC7388725__F2 Mitochondria and lysosomes in ferroptosis STAT3 CISD1 FH STEAP3 GPX4 MAL FES GLS2 PMC8778447__F1 Molecular Mechanisms Leading from Periodontal Disease to Cancer STAT3 BRAF KRAS CCND1 PMC3502626__F7 A theoretical model of synergistic interactions between resveratrol and HDAC inhibitors is presented CASP9 CASP8 RELA CASP3 SIRT1 PMC5328691__F2 Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance PLK3 ELF2 B3GAT3 CRELD1 ATF4 ATF2 PMC7388725__F1 Ferroptosis in a cell TF IPP HMGCR STEAP3 GCLC LPCAT3 FACL4 GLS2 HEL-S-64p ADA PMC5938095__F8 TrkB-mediated activation of the phosphatidylinositol-3-kinase/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus CA3 PC BDNF PMC3045483__F1 Interactions occuring in the ovarian mural granulosa cells (GC) and cumulus cells (CC) after the administration of hCG for ovulation induction MAPK1 MAPK14 EREG PGR GC BTC AREG MAPK3 PMC6628048__F1 Synthesis of bile acids (BA) CYP8B1 CYP7A1 CYP46A1 CYP7B1 CYP27A1 PMC3215729__F1 Rv2607 from Mycobacterium tuberculosis Is a Pyridoxine 5′-Phosphate Oxidase with Unusual Substrate Specificity PNP PDX1 PLP2 PMC3947125__F3 Schematic model of the autophagy pathway demonstrates several relevant markers of autophagy which are potentially influenced by a high cholesterol diet as well as possible points of regulation try resveratrol (RV) LAMP2 ATG12 MTOR ATG5 PMC4533011__F1 iNKT cell activation pathways in sepsis SAG APC CD14 CD1D PMC6811614__F1 GCs affect cross-talk of bone cells and their communication with muscle, vasculature and myeloid cell-derived osteoclasts SOST DKK1 MSC BAK1 WIF1 PMC7720507__F6 Internalization pathway of PLGA-PEI PCS NPs in MSCs CD81 NPS CD9 EEA1 CD63 IMPACT PMC7175615__F5 Pathway of TGFB2-TLR4 crosstalk within the glaucomatous TM BAMBI TLR4 MYD88 PMC5256872__F7 Transcriptome Sequencing Reveals Key Pathways and Genes Associated with Cisplatin Resistance in Lung Adenocarcinoma A549 Cells CREB3L3 BDKRB1 FGF13 FGF12 FGD1 ROCK2 MAP2K6 LIMK2 ROCK1 FGFR3 ARHA MAP2K3 PMC6368372__F1 Proposed mechanisms of action of glutamatergic modulators and other putative rapid-acting antidepressants EEF2K LHB GSK3B EEF2 BDNF PMC8965725__SF1 Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy NPS CGAS IRF3 PMC9526507__F2 Notch Signaling Pathway Contributes to Angiogenesis and Tumor Immunity in Breast Cancer HEY2 FOXC2 DLL4 TNF NOTCH1 PMC9526507__F1 Notch Signaling Pathway Contributes to Angiogenesis and Tumor Immunity in Breast Cancer MAML1 DLL4 ADAM10 DLL3 PMC7909764__F3 Senolytic therapies BRD4 OXR1 MDM2 CDK4 PMC5987016__F1 “Immune Gate” of psychopathology – mechanisms of gut derived immune activation leading to psychiatric manifestations MOG MBP CD69 TLR4 CRH LBP PMC4457640__F3 Protein Cys map to functional pathways based upon percent oxidation RAN FASN SNUPN HEL-S-69p TUFM CCT4 HEL-S-87p SRC PMC2901795__F1 Left: the EGFR pathway; Right: inhibition of the EGFR pathway by the EGFR monoclonal antibodies EGF TGFA EGFR KRAS PMC5799794__F1 Effects and underlying mechanisms of lncRNAs in various fibroses TGFB1 CFTR CYP4B1 ZEB2 N4BP2 FURIN PLXNA4 MYD88 PMC7491749__F1 Ras Signaling Pathway SOS1 GRB2 PMC11019826__F8 Utility of l-carnitine for preventing liver tumors derived from metabolic dysfunction–associated steatohepatitis EGR1 NEDD9 PMC7491749__F4 Overcoming Resistance to Drugs Targeting KRASG12C Mutation HRAS AURKA SOS1 KRAS PMC9347104__F1 Oxalate-induced apoptosis through ERS-ROS–NFKB signalling pathway in renal tubular epithelial cell ELF2 XBP1 PMC4892757__F1G MicroRNAs targeting TGFB signalling underlie the regulatory T cell defect in multiple sclerosis TGFBR2 SMAD2 SMAD4 FOXP3 TGFBR1 PMC11277110__F2 Roles of miRNAs involved in the developmental growth and apoptosis of Drosophila RHEB TSC2 TSC1 SKI PMC11277110__F4 Signaling pathways regulated by miRNAs in wing development WLS SUFU APC SMO PMC3648790__F4 Interplay Between the Cancer Genome and Epigenome RBBP7 RBBP4 PRC1 BAP1 EZH2 JARID2 HEL-S-26 ASXL2 PMC3213224__F3 Possible mechanism of reciprocal enhancement between innate and adaptive immunity, through NF-kB and STAT-1/IRF-1 pathway CXCL9 CXCR3 STAT1 CCR5 CCL5 CXCL10 PMC10959754__F4 Ubiquitination in TNF signaling SHARPIN RIPK3 CSA2 TRADD MLKL OTULIN TAB3 RIPK1 TNF CYLD TRAF2 FADD PMC11672279__S1 The brain‐targeting and therapeutic mechanism of T+A@Glu‐NPs against glioma BRD4 NPS NOTCH1 PMC6566291__F1 TGF-Beta-mediated skeletal muscle fibrosis SMAD2 SMAD4 TGFBR1 PMC4508827__F5 Toll signalling pathway of C CACTIN SP1 LDLR TRAF6 FADD MYD88 PMC4508827__F7 Jak-Stat pathway of C RAF1 PIAS1 CDK2 PTEN CDK4 PMC9476258__F2 The potential of plant extracts in cell therapy SMAD1 DKFZp781O1323 APC SMAD4 GRB2 RUNX2 CTNNB1 PMC6688483__F4 Role of CRPs in AIBD HEL-S-62p DSG1 DSG3 CD55 PMC8136123__F5 Histone deacetylase-2: A potential regulator and therapeutic target in liver disease (Review) EGF PTEN MTOR HDAC2 PMC8184824__F6 HJURP in PCa cells HJURP CDKN1A GSK3B PMC5033061__F6 An integrative analysis of the InR/PI3K/Akt network identifies the dynamic response to Insulin signaling RFC4 ENG TCP1 DGCR8 RFC2 NCOR1 AMOT RFC3 DROSHA ELF3 CTNNB1 PMC3770492__F2 A new Vitreoscilla filiformis extract grown on spa water-enriched medium activates endogenous cutaneous antioxidant and antimicrobial defenses through a potential Toll-like receptor 2/protein kinase C, zeta transduction pathway STAT3 TIRAP IRAK1 PRKCZ TRAF6 CCL20 FOS MYD88 PMC7576355__F5 FGFR axis, Ras-Raf-MEK and TP53 relationship to CDK4/6; FGFR results in activation of PI3K, Ras-Raf-MEK, STAT which increases cyclin D1, thereby promoting progression through the cell cycle CDK2 MDM2 CDK4 PMC7576355__F2 CDK4/6 pathway and FOXO3-FOXM1 axis: Cyclin D-CDK4/6 complex phosphorylates FOXM1 transcription factor which is involved in expression of G1/S phase genes FOXM1 CDK6 FOXO3A CDK4 PMC7598587__F7 Putative molecular pathway of catalpol in the skeletal muscle of type-2 diabetic mice in amelioration of glucose homeostasis and insulin sensitivity CS SIRT1 IRS1 PMC7576355__F3 Speckle-type POZ protein (SPOP) and CDK4/6 pathway CDK6 SPOP CCND1 CDK4 PMC7576355__F1 Androgen regulation of cell cycle and CDK4/6 pathway TF MTOR SRC PMC5972548__F2 Wnt signaling pathways ROR2 RYK RHO CTNNB1 PMC2671988__F2 Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder TSC2 TSC1 GRM8 NF1 NAPG PTEN MTOR PMC8904414__F1 Different Pattern of Cardiovascular Impairment in Methylmalonic Acidaemia Subtypes CBL CBLC PMC9166238__F1 Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease PINK1 HEL-S-130P TFEB MTOR SIRT1 PMC8331109__F8 Qilin Pill Exerts Therapeutic Effect on Resection-Induced Premature Ovarian Insufficiency Rats by Inhibiting the MAPK and PI3K-AKT Signaling Pathways EGF JUN TGFBI EGFR TNFSF6 KIT VEGFA TNF FOS FGF2 MAPK3 INSR RELA CASP3 IL2 KDR CDK4 PMC7139310__F1 PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases BACE1 ATF4 PMC7925768__F1 O-GlcNAcylation: the “stress and nutrition receptor” in cell stress response OGA TPR CD2 PMC7991810__F2 Signaling cascade of NC1-peptide that regulates spermatogenesis CDC42 RPS6 MTOR PMC8955086__F6 Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy NLRC4 GSDMD NLRP3 PMC9019367__F2 Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer SMAD2 APC SMAD4 CTNNB1 PMC5098226__F1 Engineering of Escherichia coli for direct and modulated biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer using unrelated carbon sources ACHE HEL-S-133P C2 PMC3920946__F1 Serine, one-carbon cycle, glycine synthesis (SOG) pathway GLDC MTHFD2 DHFR HEL-S-70p HEL-S-51e MTHFD1 PHGDH AMT GC SHMT1 MTHFD1L MTHFD2L DLD SLC25A32 NNT PSPH PMC5242448__F1 Cell signaling transduction pathways controlled by WISP-1 in different cancer cells EGFR MMP2 MMP9 VEGFA SRC NOTCH1 PMC4600536__F3 Role of IGF-I Signaling in Muscle Bone Interactions JUN BAD IGF1 GRB2 MTOR FOS PMC2966895__F2 Complement-targeted therapeutics CD59 HEL-S-62p C2 C1S SMCP C4A C4B_2 CR1 CP PMC6962593__F3 Toll like receptor 4 (TLR4)-dependent basal lung transcriptomics STAT3 MMP12 CCR5 MGA PPP1R15A DCLRE1A CEBPB RETNLB CCR1 IL1B GTF3C3 ZNF292 HCCS TTC28 GPATCH8 JUN CTSW NPEPPS EGR1 GLIPR1 HECTD1 ZMIZ1 BAG1 ISOC1 HRG DPH5 EPHB1 PTGS2 AREG HTATIP2 IL6 DFFB PMM1 FOS SPP1 MRPS23 PUM1 DYNC1LI2 ATF3 EDN1 APBB2 PMC9030821__F2 RNA-seq and Mitochondrial DNA Analysis of Adrenal Gland Metastatic Tissue in a Patient with Renal Cell Carcinoma CXCR3 CXCL12 CXCR6 CXCL13 CXCL1 CXCL16 CXCL2 CXCL6 CXCL10 CXCL14 CXCL3 CXCL11 CXCL17 IL8RB PMC11624815__F9 Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity CD47 PMC4455348__F1 Schematic of HER3 engagedment in heterodimerization and signaling BAD HSF1 GSK3B GRB2 MTOR PMC6260778__F8 Effects of the metabolite, RA, on Tregs SMAD4 FOXP3 PMC6260778__F6 Hypoxia induces differentiation of T-cells to Tregs SMAD4 FOXP3 MTOR PMC6260778__F7 Low pH induces differentiation of T cell into Tregs STAT3 SMAD4 PTEN FOXP3 PMC6260778__F5 Microenvironment recruits Tregs to tumor tissue by chemotaxis CXCL12 CCL28 CCR6 FOXP3 CXCR4 CCR10 CCL20 PMC7971890__F8 JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination JMJD6 TBK1 MAVS RNF5 IRF3 TRAF3 PMC6260778__F3 Effect of glycolysis on Tregs FOXO1 FOXO3A FOXP3 GCK MYC PMC8657471__F2 EREG/EGFR Pathway in Tumor Progression STAT3 EREG RAB27B HK2 EGFR AREG MTOR SRC PMC10281733__F10 LPS-antagonist potential of Q3G on pulmonary injury BAX GSDMD NLRP3 TLR4 PMC8657471__F3 EREG/EGFR Pathway in Tumor Progression EGF EREG HGF EGFR AREG PMC6061846__F8 Signalling pathway that mediates TRPA1-dependent PMA induced by GTN ALDH2 TRPA1 PMC8538727__F2 Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects NAPRT HEL-S-90n NMNAT1 KYNU KMO NAMPT NMNAT2 AFMID NMNAT3 PMC8657471__F4 EREG/EGFR Pathway in Tumor Progression CDH2 STAT3 EREG RAB27B EGFR ERBB2 AREG PMC7352727__F7 KRAS promotes glycolysis, protein and lipid synthesis and one carbon pathway MTOR KRAS PMC8657471__F5 EREG/EGFR Pathway in Tumor Progression EREG EGFR BRAF KRAS PMC9548442__F1 Lighting the way to host-directed immunotherapeutics TBK1 AXL STAT2 IRF9 IRF3 IRF7 TRAF3 STAT1 IFNAR2 IFNAR1 IFNB1 JAK1 TYK2 PMC6905007__F2 LRF/ZBTB7A’s silencing compromises Warburg effect and induces apoptosis in cancer cells FAS PFKP ZBTB7A BCL2 TIGAR SCO2 HEL-S-30 PMC7397197__F5 Nonautonomous replication stress response in the central nervous system TBK1 CGAS AIM2 IRF3 TNF PMC7233810__F5 Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism IPP HMGCR RHOB SQLE PMVK DHCR24 MVD HSD17B7 MVK PMC5641881__F1 Metabolic reprogramming in cancer cells under hypoxia ACSS2 GLS HEL-S-133P GYS1 FASN L2HGDH FBP1 HEL-S-26 PMC6278507__F6 Molecules associated with ‘focal adhesion’ pathway JUN HEL-S-28 PTEN ARHA GRB2 SHE PMC8047580__F1 An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy TF PLG ACE2 PMC3044157__F6 The Nuclear Guanine Nucleotide Exchange Factors Ect2 and Net1 Regulate RhoB-Mediated Cell Death after DNA Damage ECT2 RHOB NET1 PMC7430912__F5 KEGG pathway analyses of DESR genes expressed across multiple time points implicated the Adipocytokine signaling pathway as playing a prominent role in successful CNS axon regeneration STAT3 NR1C1 LEP LEPR NPY SOCS3 AgRP MTOR TRAF2 PMC8047580__F2 An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy TF VWF VCAM1 PMC8047580__F3 An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy TF TLR3 PLG HIF1A MTOR TRAF6 ACE2 PMC7991060__F1 Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action PTGIS PTGES3 PTGS1 PTGES PTGS2 PMC6691376__F8 Schematic model for the positive feedback loop between fibroblast activation and ECM deposition mediated by CD44-RhoA-YAP signaling pathway LATS1 CD44 LATS2 CS ARHA PMC8283805__F2 Comparison of COVID-19 and Lung Cancer via Reactive Oxygen Species Signaling ELF4 STAT3 EGF ADAM17 EGFR MTOR PMC8772830__F1 Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways KEAP1 HEL-S-67p IRAK1 TRAF6 TNF IRAK4 MYD88 PMC5072688__F5 Power-Law Modeling of Cancer Cell Fates Driven by Signaling Data to Reveal Drug Effects STAT3 EGFR CASP3 PMC11244889__F8 T3SS triggered LTB4 synthesis differs between neutrophils and macrophages LTB SYK GSDMD NLRP3 c-fgr STIM1 SCAP2 LYN PMC5833461__F7 EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection EZH2 ATG5 PMC6501765__F2 Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) PMCH PTH2 BDKRB1 NTS TRH HRH3 CGA SCTR TSHR TACR2 NMBR SSTR5 GHRH NMU GHRL FSHR LPA VIP MLN VIPR2 NPB PRSS1 PTH CALCA SCT GIPR PMC6501765__F3 Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) SYNJ1 IPPK CDIPT PMC6497508__F2 Role of the classical and terminal complement pathways in cold agglutinin disease and target levels of complement inhibitors HEL-S-62p C2 PMC4478296__F2 Mitogen-activated protein kinase (MAPK) signalling pathway EGFR KIT GRB2 MTOR PMC3625556__F7 The possible molecular mechanisms of pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis in rats BAX CCND1 CTNNB1 PMC4107162__F1 Mechanisms of cellular invasion by intracellular parasites HEL-S-62p CR1 PMC4702801__F1 Snapshot of Colorectal Cancer Atlas features LAT PTMS HEL-S-11 PMC10970282__F8 Construction of the potential miRNA-target negative correlation regulatory network involved in the FoxO signaling pathway following G CTSL BNIP3 TRIM63 FBXO32 PMC9523361__F5 Tuning Rex rules HTLV-1 pathogenesis CTRL IFNG IL2 ATF2 PMC7159149__F6 Commonly dysregulated genes CRP ECSIT CD40 STAT3 EGF LTA TRADD CD27 APC HRG IL17A MTOR CS AHSG MOK BAG2 PMC9496762__F2 Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis TRIM13 TRIM31 STAT3 TRIM32 EGFR SOX2 MTOR CTNNB1 TRIM21 TRIM44 TRIM28 TRIM24 TRIM47 TRIM37 RELA MAGEA6 MAGEA3 TRIM8 TRIM11 TRIM45 PMC5525000__F1 Schematic representation of sulfides (H2S) synthesis and oxidation pathways SQOR HEL-S-64p PMC4211077__F2 Advances in understanding of bile acid diarrhea FGF8A FGFR4 PMC3774122__F2 NRF2-mediated oxidative stress response pathway HMOX1 PRKCI FTL GCLC DNAJC19 VCP PMC2937358__F1 ERAlpha-Negative and Triple Negative Breast Cancer: Molecular Features and Potential Therapeutic Approaches EGFR CXCL2 CXCL6 CXCL3 PMC10298409__F11 Integrated Transcriptomics and Metabolomics Analysis of the Fructan Metabolism Response to Low-Temperature Stress in Garlic GLA PMC9685423__F1 Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry CYP11A1 HSD3B1 CYP7B1 CYP27A1 AMACR SLC27A5 H1-3 PMC7432057__F1 Mechanisms involved in the effects of adiponectin in different liver diseases including hepatic I/R CRP SAA1 STAT3 FAS RBP4 TRAF6 FGF2 MYD88 UCP2 TLR4 LCN2 SIRT1 HEL-S-44 PMC7432057__F3 Adiponectin and leptin in the progression of nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC) STAT3 SOCS3 MTOR PMC7408019__F6 KLF4 acts as a negative regulator of wt-CFTR but has its function disrupted in the F508del–CFTR cells KLF4 BAG3 GSK3B CFTR PMC6439804__F1 Hedgehog-Induced Osteogenesis SAG MSC SMO GLI3 PMC5343808__F1 Sonic Hedgehog Pathway: Shh acts on Ptch to inhibit the repression of Smo by Ptch SUFU SMO MYC PMC5343808__F2 Wnt Pathway: In the presence of Wnt ligands, Dsh blocks the Beta-catenin destruction complex consisting of Axin, APC, CK1, GSK3B MMP7 NEUROD1 APC GSK3B MYC CCND1 CTNNB1 PMC6540809__F1 B cells mediate MS pathology through antibody-dependent and antibody-independent mechanisms LTB LTA CXCL13 PC PMC8371405__F2 Long Non-coding RNAs on Bladder Cancer DNMT3B FOXQ1 ZEB2 KRAS TUG1 PMC7059628__F8 Comparison between wild‐type and gas7‐knockout neurons of mitofusin regulation by the PINK1 and parkin‐mediated mitophagy pathway GAS7 PINK1 CDK5 MFN1 MFN2 PMC8371405__F3 Long Non-coding RNAs on Bladder Cancer HNRNPL E2F4 TET1 SOX2 GSK3B SMAD4 EZH2 REL CCL2 PMC2923369__F2 Auto-layout of ‘Caffeine (C) neighborhood’ based on Ingenuity curated finding (IPA, Ingenuity® Systems) LEP CRH NPY PMC4548197__F1 Neuronal apoptosis network BAX CASP9 BAD CASP3 BCL2 MDM2 PMC6381369__F1 An illustrated view of Netrin-UNC5B signaling DCSTAMP JUN ALPL SELE CALY PRKCA HEL-S-11 RGMA PMC5729908__F9 m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway JAK3 IL7R IL7 METTL3 JAK1 PMC4323367__F7 Summary of radiation-induced persistent alterations of IGF1 and leptin signaling pathways observed in our study IGF1 IGF1R IRS1 PMC8745001__F4 Cytosolic Quality Control of Mitochondrial Protein Precursors—The Early Stages of the Organelle Biogenesis UBR1 ATF5 HSF1 OMA1 ATF4 EIF2A PMC139865__F12 Innate immunity pathways in Drosophila NFKB1 NFKB2 TRAF6 REL PMC4101637__F10 Working hypothesis on the distinct mechanisms by which TNFA/IL-1B and IL-6 inhibit the hepatic GH-IGF-I pathway during inflammation GHR IL1B PMC10215516__F2 PI3K/AKT/mTOR signaling pathway activation in HPV-positive HNCs SLPI PTEN MTOR PMC4258093__F3 Canonical Wnt signaling APC AXIN1 CTNNB1 PMC4030405__F1 Complement system C6 C7 HEL-S-62p C2 C1S C1R C9 CP PMC8847026__F12 “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer ACLY CIC PC CPT2 NNT PMC5903427__F1 Purine salvage pathway and HGprt function () PNP ASL ADA PMC4258093__F1 PI3K signaling RHEB TSC2 RICTOR TSC1 PTEN MTOR IRS1 PMC8509287__F2 Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis MAVS IRF3 MYD88 PMC3770093__F1 Sphingolipid biosynthetic pathway GAL GBA2 PMC6111072__F10 Schematic Diagram Illustrates and Summarizes the Role and Signaling Pathway of PAK1 in Regulating Human SSCsPAK1 is mediated by EGF, but not by GDNF or FGF2; PDK1, ZNF367, and KDR are the targets of PAK1 EGF GDNF PAK1 ZNF367 EGFR KDR FGF2 PMC8207884__F4 Correlation Between the Evolution of Somatic Alterations During Lymphatic Metastasis and Clinical Outcome in Penile Squamous Cell Carcinoma NRK KIT PTEN MTOR KRAS ARAF HRAS RICTOR SOST TSC1 ALK ATM APP PMC10486691__F6 Association of EN2 with ERBB, insulin, BCR-ABL and JAK signaling STAT3 JUN BAD PIM1 STAT2 MCL1 CRKL PTPN1 MTOR MYC CRK STAT1 CBL GFAP RAPGEF1 STAT4 MDM2 GRB2 GAB2 PMC7397749__F1 Synthesis and metabolism of PUFAs LPA ELOVL2 SAG LPCAT3 MBOAT7 PC FADS2 ELOVL5 FADS1 PMC7500861__F5 Metabolic pathway differences between LLO118 and LLO56 and identification of mGPD2 as a candidate gene AGPAT5 PIK3CD ACACA CDIPT PLCG1 UCK2 PLOD2 UMPS PLD3 GLYCTK GOT2 CAD ST3GAL6 HK2 FASN ALAS1 CMAS GLO1 HEL-S-30 NANS HGSNAT ACSS1 ADSL PNPLA7 GPCPD1 PGAM1 PAICS SDHB LPCAT4 HEXA GPD2 ENO3 PIGA PHGDH ME2 HEL-S-68p HAT1 PFKP PPT1 PIGL ALDH9A1 DLD ACADL PSAT1 PMC7761926__F1 General view of canonical and non-canonical Wnt signaling CDC42 ROR1 JUN APC ROR2 GSK3B LRP5 LRP6 ATF2 ARHA RAC1 CTNNB1 RNF43 ZNRF3 GPR49 DAAM1 PMC7736362__F1 Rewiring yeast metabolism to synthesize products beyond ethanol PDC CIT PMC5612418__F3 Neuroprotective actions of perinatal choline nutrition CHDH ChAT MTR MAT1A PMC3467082__F1 Translation of glutamine codons in yeast GC UACA PMC6415285__F2 Statins on several pathways involved in bone metabolism BMP2 CCL2 PMC11979612__F12 Aconiti Lateralis Radix Praeparata ameliorates heart failure via PI3K/AKT/Bnip3 pathway OPA1 BNIP3 ATG5 PMC7761926__F2 Wnt targeting agents for the Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 RNF43 TNKS PORCN NOTUM CER1 ZNRF3 TNIK GPR49 WIF1 PMC9619093__F2 Joint together: The etiology and pathogenesis of ankylosing spondylitis SOCS1 STAT3 RORC RUNX1 IL24 TLR4 SOCS3 PMC7158891__F3 An integrated overview of the immunosuppressive signaling pathways involved in the interaction between exosomal PD-L1 and T cells ZAP70 CD80 CD69 TNF PPL LCK PMC8875594__F1 PCSK9 Promotes Cardiovascular Diseases: Recent Evidence about Its Association with Platelet Activation-Induced Myocardial Infarction PCSK9 CD36 LDLR IL1A SRC PMC4707198__F5 Schematic illustration of Hog1-mediated posttranslational and transcriptional hyperosmotic stress response pathway GPD1 SLN PMC1479092__F1 The mitochondrial generated ROS-mediated activation of the p38 MAPK stress response pathway TF JUN JUNB ATF1 ATF2 PMC2892298__F8 Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors TEAD2 SOX11 SOX12 SOX4 PMC7849354__F2 Pseudomonas aeruginosa as a Model To Study Chemosensory Pathway Signaling F7 PMC7849354__F3 Pseudomonas aeruginosa as a Model To Study Chemosensory Pathway Signaling F7 HBM PMC4748038__F2 Shigella exploits Ca2+signaling to delay cell death and to dampen inflammation BAX CASP4 CASP3 BNIP3 NOD1 GADD45A PMC3296768__F5 Targeting Bone Remodeling by Isoflavone and 3,3′-Diindolylmethane in the Context of Prostate Cancer Bone Metastasis TES SLC10A2 NRCAM RARB SKI FOS PMC6580952__F1 Salient features of EBV latent transcripts during B-cell transformation, followed by B-cell lymphoma development CD40 ATR TRADD PIM1 IRF4 ATG3 CDK6 BCR CCND2 PAX5 E2F6 CDK2 BCL2 MDM2 ATG5 CCND1 BCL6 PMC7443136__F8 TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury COL1A1 GSDMD NLRP3 TLR4 MYD88 PMC2586899__F4 The involvement of TNFAlpha-mediated signaling pathways in insulin resistance TSC2 TSC1 MTOR IRS1 PMC7927199__F9 Proposed schematic model summarizing the role of GNL1 as an antiapoptotic protein BAX HEL-S-107 BCL2 PMC3324360__F5 Simplified TGFB pathway BAMBI ATF3 DDIT3 ID1 TGFBR1 PMC7554781__F2 Glial cell line-derived neurotrophic factor family ligands (GFLs) signaling PSPN FYN GDNF ARTN NRTN GDF15 SRC RET PMC4064060__F4 Molecular interactions between Wnt/Beta-catenin and PPARG signaling in colorectal cancer cells APC GSK3B PTEN CCND1 CTNNB1 PMC9438157__F9 M6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway GEM DDIT4 ALKBH5 SMG5 MTOR PMC9370682__SF1 Design, Synthesis and Biological Evaluation of [1,2,4]Triazolo[1,5-a]pyrimidine Indole Derivatives against Gastric Cancer Cells MGC-803 via the Suppression of ERK Signaling Pathway H1-5 H1-6 H1-8 HIST1H1E H1-1 H1-0 H1-3 H1-2 PMC12234474__F5 Targeted Therapeutic Strategies for PDAC HEL-S-308 HEL-S-162eP MTOR PMC4402390__F6 Metabolic network of CcsR-dependent targets and influence on cell regulatory networks COX1 CYC1 PMC8438693__F3 Protein phosphatase 2A in kidney disease (Review) TRADD TRAF2 FADD PMC4064060__F1 The Wnt/Beta-catenin signaling in epithelial cells CD44 ROCK2 APC ROR2 LRP5 LRP6 RHO CCND1 UNK CTNNB1 PMC6614411__F4 Pathway-based analysis for glycolysis, TCA cycle and pentose phosphate pathway RPE PGC MALL MAL AIP ATM PMC9170957__F2 From Therapy Resistance to Targeted Therapies in Prostate Cancer TF EGFR SRC PMC1236698__F2 Molecular mechanisms of autophagy ATG10 ATG3 ATG12 PI3 ATG14 ATG5 PMC6071982__F4 Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny HELZ2 ACOX1 DAGLA SCARB1 FASN ACACA PMC5479302__F8 Proposed signaling pathway activated by CTS in CCA cells.Notes: The potential mechanism of apoptosis induced by CTS in HCCC-9810 and RBE cells STAT3 BAX PMC9370780__F11 Cornuside Is a Potential Agent against Alzheimer’s Disease via Orchestration of Reactive Astrocytes THBS1 GFAP TGM1 AMIGO2 SERPING1 HEL-S-62p PBX3 SYP CD14 BDNF GBP2 PMC12128267__F9 Proposed mechanism of gastrointestinal exposure to SiO2 NPs induced AD-like neurotoxicity HDAC3 HDAC1 NPS PMC2743935__F5 Calcium signalling and cell-fate choice in B cells REST TRPM5 PMC10556522__F2 Genomic rearrangements that contribute to pathogenesis of ALK- ALCL () represents ALK- ALCL harboring DUSP22-rearrangement and associated signaling pathways ROS1 IKZF1 ERBB4 PRDM1 NFKB2 IRF4 MYC NCOR2 CD58 MLL2 WWOX BATF3 ANKRD11 TBL1XR1 PMC6071982__F5 Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny MSRA CTH MTR OPLAH HEL-S-64p HEL-75 PMC6744711__F2 Cross-talk between DNA damage and immune response ATR CGAS IRF1 ATM IRF3 PMC8450340__F8 Qiangjing Tablets Regulate Apoptosis and Oxidative Stress via Keap/Nrf2 Pathway to Improve the Reproductive Function in Asthenospermia Rats RBX1 JUN KEAP1 MAF PMC6591470__F2 Schematic illustration of the cell type-specific effects of impaired PI3K-Akt signaling in AD brain GSK3B IL1A MTOR BDNF PMC7151139__F1 BMP signaling pathway SMAD1 DKFZp781O1323 SMAD6 SMAD4 PMC9113095__F8 Genetic evidence for the requirements of antroquinonol biosynthesis by Antrodia camphorata during liquid-state fermentation COQ3 COQ2 COQ5 PMC10556522__F1 Pathogenic signaling pathways in ALK+ ALCL () represents deregulated T-cell receptor signaling pathways mediated by NPM::ALK ACLY STAT3 BAD OSM MTOR STAT1 FYN ALK ITK HDAC2 ATL1 IL9 IL17F CD48 CD244 IL10 IF2B1 MSH2 MSH3 IL13 SQLE IL4 IL6 IF2G GATA3 HDAC1 ICOS IL7 IL23R LEF1 LCK PMC6591470__F1 Schematic presentation of PI3K-Akt intracellular signaling TREM2 SYK GSK3B PTEN GRB2 PMC8280023__F3 Gut Microbial Metabolites in Parkinson’s Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment BAX FIS1 OPA1 MFN1 PMC5845444__F2 13C metabolic flux analysis of E HEL107 TAC3 MAL PTS CIT PMC2933224__F1 Gradient Descent Optimization in Gene Regulatory Pathways CASP9 FAS CASP6 CASP2 TRADD CASP4 CASP3 FADD PMC8945569__F2 Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer’s Disease: A Review NLRP3 IL1B PMC6467375__F5 PID1 alters the antilipolytic action of insulin and increases lipolysis via inhibition of AKT/PKA pathway activation TG PDE3B PMC4586249__F3 RecQ helicases in base excision repair (BER) and double-strand break repair (DSBR) TDP1 RAD52 MPG RAD51 RMI2 FEN1 PCNA APTX WRN NEIL1 IL1A BLM PARP1 OGG1 PNKP LIG1 DNA2 UNG POLE RMI1 PMC2562925__F8 Schematic depicting the roles of p53 and wnt7b in proposed pathway for NGF-mediated neurite outgrowth in PC12 differentiation NGF FZD7 FZD9 WNT7B PMC7985079__F1 Modified model of the HMA-induced viral mimicry in leukemic cells MAVS IRF9 RNASEL IRF7 RAC1 PMC4266699__F1 HER family and EGFR signaling pathway EGF HBEGF TGFA EGFR MTOR PMC7397772__F1 Apolipoprotein E (APOE) exhibits both proinflammatory and antiinflammatory properties NLRP3 TLR4 CXCL5 APOE LDLR IL1B MYD88 PMC4475926__F9 COX-2 increases insulin signaling by downregulation of miR-183 DDX5 DGCR8 DROSHA IRS1 PMC10874461__F5 Pathological mechanisms of osteoporosis induced by diabetes, glucocorticoids, and psychological stress SOST CRH GC GHRH MSC NMU GIP NPY IGFBP2 PTH CTNNB1 PMC10874461__F2 X-linked osteoporosis in males VWF APC LRP5 LRP6 CTNNB1 PMC5776968__F5 Signaling pathway responding to oligodeoxynucleotides of class C SYK TBK1 CGAS MAVS TLR9 AIM2 IRF3 IRF7 TNF MYD88 BTK BCR LYN IL1B PMC6636046__F7 Enriched KEGG pathways generated by ClueGO and Cluepedia PPARG CD80 CGAS GNAO1 HHIP GDPD1 ARPC2 EGFR RNASEL SDC4 GABRB3 PLA2G12A AREG NOTCH2 SLC44A1 SLC44A2 EML4 CTNNB1 HEL114 GNG2 GNAS HLA-E NRAS PMC4751379__F8 Ingenuity pathway analysis of GH signaling after hepatectomy SOCS1 STAT3 SOCS7 STAT1 CEBPA IGF1 SOCS4 SOCS2 A2M SOCS3 IGF2 IRS1 PMC9014242__F8 Signaling Pathways That Mediate Alveolar Macrophage Activation by Surfactant Protein A and IL-4 MAJN PKD1 JAK3 JAK1 PMC4706435__F6 MiR-124 Promote Neurogenic Transdifferentiation of Adipose Derived Mesenchymal Stromal Cells Partly through RhoA/ROCK1, but Not ROCK2 Signaling Pathway ROCK2 SP1 ROCK1 ARHA PMC4499589__F7 EphA2 Receptor Signaling Mediates Inflammatory Responses in Lipopolysaccharide-Induced Lung Injury EPHA2 TLR4 IL1B PMC3141988__F6 An E-cadherin–mediated Hippo signaling pathway LATS1 LATS2 PMC8686226__F3 Developing landscape of combinatorial therapies of immune checkpoint blockade with DNA damage repair inhibitors for the treatment of breast and ovarian cancers IFNG TBK1 ATR CGAS CCL3 BRCA1 ATM IRF3 CTLA4 PMC9272524__F3 Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance SIRT3 MTDH ACO2 PMC4083693__F1 Wnt signaling is required for long-term memory formation CDH2 APC TEF CTNNB1 PMC4292235__F1 Assembly and mechanism of action of CpG ODN/Tat nanorings IFNG PDC TLR9 MYD88 PMC3306972__F1 ABPP processing, the adaptor proteins interacting with its intracellular domain and the pathway leading to ERK1/2 activation NUMB APP GRB2 PMC9204553__F4 CTRP9 overexpression attenuates palmitic acid-induced inflammation, apoptosis and impaired migration in HTR8/SVneo cells through AMPK/SREBP1c signaling RHEB TSC2 FAS CD36 F2 HEL-S-5 GLA CFTR INS PMC5685850__F4 Wnt receptor signaling pathway and regulation of Rab GTPase activity involved in miRNA expression NFATC2 SMAD4 NR1C2 MAPK9 SFRP1 CTNNB1 BTRC CTNNBIP1 VANGL1 FRAT2 PRKACG TBC1D28 PRKCA TBC1D17 CREBBP DVL3 RUTBC1 TBC1D16 PMC11641400__F3 HA35 enriches signaling pathways involved in growth and antioxidant response in the developing murine intestine UBA3 SUMO1 UBE2B RPS27A UBE2F MDM2 MTOR KRAS PMC5664070__F3 An overview of signaling cascades involved in PLK1-induced EMT FOXM1 GSK3B ZEB2 PLK1 PMC6687767__F1 Natriuretic peptide signaling in adipose tissue NPS GC UCP1 ATF2 PMC8620858__F1 Hypoxia: The Cornerstone of Glioblastoma RBX1 HEL-S-133P SOX2 EPO BNIP3 PTEN MTOR UBXN7 ELOC NOTCH1 VHL PMC5014572__F3 Roles of MAS-related G protein coupled receptor-X2 (MRGPRX2) on mast cell-mediated host defense, pseudoallergic drug reactions and chronic inflammatory diseases NPS ORAI1 MBP MRGPRX2 EPO PMC12121061__F8 Schematic model illustrating the mechanism of combined treatment of VEN and C-82 CASP3 DFNA5 CTNNB1 PMC9150122__F1 Biophysical Survey of Small-Molecule Beta-Catenin Inhibitors: A Cautionary Tale BCL9 MMP7 LRP5 LRP6 CCND1 CTNNB1 PMC3890705__F6 Proangiogenic mechanisms activated in the omentum during transcoelomic EOC metastasis in the presence of anti-VEGF therapy HGF TIMP1 CXCL16 IGFBP2 IGFBP7 MMP9 VEGFA PF4 PMC8622675__F2 Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis? LATS1 LATS2 SRC PMC8371277__F2 Lipid droplets and lipid mediators in viral infection and immunity LTB TG LOX PMC3071916__F2 Insights into the Pathogenesis and Treatment of Cancer from Inborn Errors of Metabolism FH HEL-S-26 PMC7139621__F1 Therapies fighting breast cancer through the fibroblast growth factor receptor (FGFR) pathway PTX3 FRS2 GRB2 MTOR CDK4 PMC5983188__F1 Cytokine/long noncoding RNA (lncRNA) interplay in controlling immune cell development and function CCL5 PTGS2 TNF CXCL8 PMC4581295__F2 Signal pathways of chondrocyte hypertrophy FRZB SMAD1 DKFZp781O1323 SOX9 BMP4 APC GSK3B BMP2 IHH RUNX2 CTNNB1 FGF2 PMC6509841__F7 DEGs relevant to the “protein processing in endoplasmic reticulum” pathway under group “D vs SVIP BAX UBC SELL ELF2 SKP1 ATF4 EIF2A CP PMC3064560__F3 Analogue 3 also showed potent antiproliferative activity against the highly invasive non-small-cell lung cancer cell line CL1-5 with an ED50 value of 0.11 μM CDC2 ZW10 RCC1 RAN HCTP4 PMC11083511__F1 Subsets and functions of CD4+ T cells AHR IRF4 FOXP3 BCL6 GATA3 PMC5715135__F7 Canonical pathway of molecular mechanisms of cancer from IPA showing dysregulated mRNA targets along with their potential differentially expressed miRNA regulators found in Lebanese samples MAX BAX ATR BAD FRK MYC RBL1 CRK SUFU WNT1 GRB2 LEF1 UNK PMC8393536__F1 Myostatin/Activin-A Signaling in the Vessel Wall and Vascular Calcification GDF8 ALK SMAD2 CRIPTO TNF PMC8303169__F2 Pivotal Player: Components of NFKB Pathway as Promising Biomarkers in Colorectal Cancer RELA RELB TNF PMC12237497__F10 Working model of GPR120 modulation of mammary gland function CTCF CD36 TLR4 FASN ACACA TRAF6 CXCR4 CXCL14 PMC8303169__F3 Pivotal Player: Components of NFKB Pathway as Promising Biomarkers in Colorectal Cancer STAT3 EGFR KRAS PMC10512452__F6 IL-10 Exerts anti-inflammatory effects through STAT3 signaling pathway STAT3 TLR4 JAK1 MYD88 PMC10558228__F1 NFKB signaling pathway and targets of inhibitors against neuroinflammation in AD ADIPOR1 TLR4 CD14 TRAF6 TNF MYD88 PMC6727029__F2 Pre-synaptic and post-synaptic mechanisms regulated by PPT1 GAP43 FYN CRMP1 VAMP2 PPT1 SNAP25 PMC10558228__F3 NLRP3 signaling pathway and targets of inhibitors against neuroinflammation in AD GSDMD NLRP3 TLR4 PMC10558228__F4 PPAR, STAT3 and PI3K/Akt signaling pathways and targets of inhibitors against neuroinflammation in AD STAT3 PTEN TNF PMC10558228__F5 Targeting inflammatory signaling pathways with drugs shows promise in AD treatment C6 STAT3 NLRP3 APP PMC11908107__F8 LXR-alpha agonist is involved in various biological functions in liver transplants MTOR TNF PMC7264106__F1 TNFR1 and TNFR2 signaling pathway TRADD MLKL TRAF2 FADD PMC4201175__F1 Biochemical and genetic processes in malignant mesothelioma BAP1 PTEN MDM2 NF2 PMC6466115__F1 Biosynthesis pathway of histo-blood group antigens (HBGAs) by stepwise addition of monosaccharides to precursor structures FUCA1 FUT2 FUT3 PMC5499698__F1 mTOR-signaling pathway: mTORC1 and mTORC2 complexes and the key signaling nodes that regulate mTORC1 and mTORC2 RHEB MLST8 TSC2 RICTOR TSC1 TTI1 PTEN GRB2 MTOR DEPTOR PMC7230684__F1 Folate metabolic pathway disrupted by methotrexate (MTX) DHFR SLCO1B1 TYMS SLC19A1 PMC5499698__F3 Alterations in mTOR signaling pathway on spermatogenesis RHEB RPS6 TSC2 TSC1 PTEN PMC7286861__F6 The PGD2–GPR44 axis in human islets exposed to hyperglycaemia and proinflammatory cytokines PDX1 FOXO1 MAFA GSK3B PMC8820546__F2 AMPK/mTOR Signaling Pathway in Anticancer Activity of Metformin RHEB BAX TSC2 TSC1 IGF1 ATM CCND1 PMC5454408__F2 HBV modulation of innate immune sensors TLR1 RIGI MAVS TLR3 TIRAP PDC TLR9 AIM2 EZH2 UNK MYD88 PMC3254670__F1 Metabolic connections during apoptotic cell engulfment UCP2 MFGE8 AXL CD36 C1QB ABCA1 MERTK PMC8578102__F1 Transforming Growth FactorB and the Renin-Angiotensin System in Syndromic Thoracic Aortic Aneurysms: Implications for Treatment SMAD2 SMAD6 SMAD4 ARHA SKI TWIST1 PMC6220063__F1 Eicosanoid biosynthesis and PGE2 signaling via EP receptors COX1 HEL-S-11 PMC4600637__F1 Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia CDC42 HEL-S-47e LIMK2 PAK1 LIMK1 CDC42EP4 CDC42EP3 PMC6554373__GA Venlafaxine Mitigates Depressive-Like Behavior in Ovariectomized Rats by Activating the EPO/EPOR/JAK2 Signaling Pathway and Increasing the Serum Estradiol Level POR EPO BCL2 BDNF PMC10374743__F2 Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells HEL-S-133P HK2 HEL-S-162eP PMC8581319__F1 Epithelial‐Mesenchymal Transition in colorectal cancer: Annexin A2 is caught in the crosshairs STAT3 EGF HGF IGF1 ANXA2 SRC HEL-S-15 PMC8086286__F2 Expression and regulatory roles of lncRNAs in G-CIMP-low vs G-CIMP-high Glioma: an in-silico analysis DUSP5 EPHA2 EZH2 BBC3 MYC SPI1 CAMLG BMI1 PIDD1 HOXA1 MAP3K8 FOXO4 TIAM1 CCNE1 SNAI1 HOXA4 GADD45B FGFR3 NOTCH1 BIK PMC6873590__F1 Glycolysis and biosynthetic pathways emanating from glycolysis GLDC MTHFD2 TH MTHFD1 HEL-S-162eP SHMT1 MTHFD2L HEL-S-51e PSPH PMC7253636__F1 Human pathway of assembly of lipoyl moieties on its cognate proteins GCSH LIPT2 LIPT1 LIAS PMC6328441__F4 Mechanism of CHOP regulation in ER stress induced apoptosis BAX ATF3 BAG5 ATF4 EIF2A TRAF2 UNK PMC3654194__F1 Spatial and temporal organization of ubiquitin networks CD40 SHARPIN MAP3K7IP1 TRADD IRAK1 TRAF6 TRAF2 IRAK4 MYD88 PMC6328441__F1 Upstream regulatory pathway of CHOP ATF4 EIF2A PMC3504431__F1 MTOR pathway RHEB TSC2 GRB10 TSC1 ULK1 DEPTOR IRS1 PMC7779329__F3 SARS-CoV-2 and relevant biological processes that involve ACE, PGR, FXIIIB, and tPA TMPRSS2 PGR PLG ACE2 PMC4889230__F1 The stress-triggered signaling pathway leading to DNA damage and cell death MGST2 NOX4 PMC4967197__F5 Peroxisome proliferator-activated receptor (PPAR)-related fasting response in heart HEL107 PPARG HEL-S-273 HEL-S-133P CFD ETHE1 CPD TXN NR1C1 HADHB DLAT PPARGC1A HEL-S-44 PMC7215285__F3 Metabolic pathways including glycolysis, pentose phosphate pathway, tricarboxylic acid cycle, and lipid synthesis with target non-coding RNAs ACLY HEL107 FH HEL-S-133P HK2 PMC4655822__F3 Establishment and Dysfunction of the Blood-Brain Barrier CDH2 PMC11678534__F2 Creatine in the promotion of cancer malignancy BAX JUN SLC6A8 HEL-S-20 HEL-S-29 HK2 SMAD2 PMC7039327__F2 B-cell receptor signaling triggers formation of a multicomponent “signalosome,” which can activate BTK, AKT, PI3K, PLCG2, and BLNK, and CD19, a coreceptor important for PI3K activation CD79B SYK CD79A BTK ARHG BCR PLCG2 BLNK CD19 LYN ARHA RAC1 PMC9080378__F7 Genomic Understanding Reveals the Important Role of FGFR2 as Paeoniflorin Target for Circumventing Breast Cancer Resistance to Tamoxifen SOX9 BCL2 FGFR2 PMC3753040__F1 Chromatin Recruitment of DNA repair proteins: Lessons from the Fanconi Anemia and Double Strand Break Repair Pathways ATR BRCA2 FANCM FANCL FANCA FANCC FANCB FANCE FANCG FANCD2 FANCF BRCA1 USP1 PMC6450717__F7 Loss of CHP1 rewires glycerolipid metabolism in proliferating cells LPA TG GNPAT GPAT4 ABCD3 PC CHP1 PMC3880903__F8 Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in Mouse and Human ABCC3 ABCC2 PMC9403138__F3 Microbiota-derived short-chain fatty acids: Implications for cardiovascular and metabolic disease CXCR1 NLRP3 CX3CR1 CCR2 CCL2 CCR1 PMC9332593__F2 DNA Damage Response Regulation by Histone Ubiquitination BARD1 BRCA1 RNF168 RNF8 PMC8131681__F2 Smad Dependent TGFB and BMP Signaling Pathway in Bone Remodeling and Therapies MAP3K7IP1 SMAD2 NFATC1 TRAF3 TRAF6 PMC11647263__F6 In SAE, Nogo-A plays a critical role through a series of complex signaling pathways NLRP3 IRF3 TNF PMC8131681__F1 Smad Dependent TGFB and BMP Signaling Pathway in Bone Remodeling and Therapies SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC7469280__F2 TRAF6 mediates signaling transduction pathway ECSIT BAD MAP3K7IP1 TRAF6 MYD88 PMC7469280__F3 TRAF6 regulates tumor related to signaling transduction pathways ECSIT CD40 LRP5 MMP9 TRAF6 CTNNB1 PMC9563021__F7 Baicalin Modulates Inflammatory Response of Macrophages Activated by LPS via Calcium-CHOP Pathway NOS2 STAT1 FAS PTGS2 PMC4759477__F3 Platycodin D‐induced G2/M phase cell cycle arrest in cancer cells CDC2 WEE1 MDM2 CCNB1 PMC6290461__F2 Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases RAD51 PCNA PARP1 PMC6290461__F1 Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases ZMPSTE24 IL6 MTOR PMC3926427__F4A Targeting Fibroblast Growth Factor Pathways in Prostate Cancer FGF9 FGFR1 FGF10 FGF8 FGF2 PMC9553876__F1 Molecular pathway changes caused by TTFields on glioma, GBM, MPM, NSCLC, and breast cancer Fig. 1A, Gliomas and glioblastomas CGAS BRCA1 AIM2 ARHA MTOR PMC7929421__F2 Unfolded protein response pathway BCL2 ATF4 EIF2A XBP1 TRAF2 PMC9553876__F2 Molecular pathway changes caused by TTFields combined with radiotherapy or drugs in GBM, MPM, NSCLC, and breast cancer FANCD2 STAT3 JUN BRCA1 FANCA PMC7929421__F3 Immune response activation pathway TBK1 MAP3K7IP1 TAB3 IRF3 IRF7 TRAF3 TRAF6 NOX4 IRAK4 MYD88 PMC12111645__F7 THC-induced neurotoxicity Via MCU MCU EFHA1 SLC25A23 SLC25A25 PMC8148118__F3 Multifaceted Role of AMPK in Viral Infections TG TSC2 HMGCR TXNIP FOXO1 ULK1 TFEB HDAC5 HDAC7 PMC12006087__F4 KEGG pathway analysis TH ICOS BCL10 ITK GRB2 TNF CDK4 PMC6196273__F2 Iron chelators modulate multiple immunometabolic pathways via the stabilization of HIF1A IFNG FAS HIF1A IL1B PMC10733979__F1 Key cellular metabolic pathways in which NAD(P)H and FAD are involved, including glycolysis, the TCA cycle, oxidative phosphorylation, fatty acid oxidation and synthesis, and the glutathione pathway PRX UCP1 NNT PMC8989428__F3 Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) BAX SLC3A2 GPX4 SLC7A11 ATF4 GRB2 PMC4067916__F1 The Hippo pathway in mammals LATS1 FRMD6 LATS2 AREG PMC5802554__F1 Mutational heterogeneity of angioimmunoblastic T-cell lymphoma indicates distinct lymphomagenic pathways TET2 VAV1 ARHA PMC7577509__F1 Clinical implications of biomarker interactions in CRC PI3 BRAF ERBB2 PMC2529314__F8 Over-representation of Toll-like receptor signaling pathway genes CA14 PMC4527365__F2 Activation and downstream signaling of class III RTKs FLT3 GRB2 CSF1R PMC10967848__F1 Representation of metabolic pathways of lipoprotein APOC2 LPL APOC3 MTTP LDLR PLTP ABCA1 PMC9152215__F4 Network Pharmacology and Experimental Verification Strategies to Illustrate the Mechanism of Jian-Pi-Yi-Shen Formula in Suppressing Epithelial–Mesenchymal Transition ACAN TH DEK POLL PMC2529314__F7 Interactions of KEGG pathways for differentially expressed genes in different stages of PAD BCR FER APP PMC5361678__F6 Resveratrol fuels HER2 and ERAlpha-positive breast cancer behaving as proteasome inhibitor RICTOR PTEN MTOR SRC DEPTOR PMC4818883__F2 Frequently mutated genes in ErbB signaling pathway CRK HBEGF JUN BAD FRK BTC NRG3 MTOR SHE NRG4 PMC8516279__F7 Signal and interaction networks of CD36 PPARG TNKS2 DGAT1 CD36 TXNIP MAFA FABP1 CTNND1 SLC27A2 CTNNB1 ACSS2 LY96 NLRP3 TLR4 SRC PTGER3 STAB2 MRPL39 UMOD C1QTNF7 STAB1 CD14 TEFM ZC3H10 LAMB4 FABP4 HPS3 NR1C1 APOB CREBBP PLTP PMC4189793__F1 Involvement of Tumor Macrophage HIFs in Chemotherapy Effectiveness: Mathematical Modeling of Oxygen, pH, and Glutathione SRC NOX4 PMC2430908__F8 Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity TSLP PREB RBPJ PMC4485330__F1 Regulation of the interleukin (IL)–17 axis is essential for oral immunity and homeostasis STAT3 STAT1 APC PMC8350546__F7 NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells STRA8 RHEB PTMAP7 ANP32B DAZL CCND1 NANOS2 PMC12130335__F9 MAVS’ role in MIRI BAX RIGI MAVS TRAF5 BCL2 TRAF6 PMC5568613__F1 Pathway of corticosteroid synthesis in the adrenal cortex CYP17A1 CYP11B2 CYP11A1 PMC4849781__F2 HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data CMA1 PALM GRAP PMC5124618__F1 Changes in the VE response to inflammatory stimuli during sepsis TFPI MPO PMC6518927__F6 Network of genes targeted by miR-21, based on miRTarBase predictions and analysed by String CASP8 RECK SPRY4 E2F2 EZH2 PTEN MMP9 TNS1 TGFBR1 SPRY2 RB1 CBL SMURF1 CYFIP1 EIF4E3 RMND5A GID4 GRB2 SPRY1 FADD PMC5320444__F5 Comparative physiological and transcriptomic analyses provide integrated insight into osmotic, cold, and salt stress tolerance mechanisms in banana TF MYB PMC7318076__F2 Representative strategies to optimize cytoplasmic signaling of CD28ζ CAR STAT3 IL2RB PMC5678957__F1 Cell biology of APOL1 STAT3 TFEB APOL1 PMC6206573__F8 Ban-Xia-Xie-Xin-Tang on TNF signaling pathway MAFK TRADD ITCH JUNB LIF AIP TRAF3 NOD2 CASP3 DKFZp666G145 TRAF1 MRPL4 REL TRAF2 CASP10 FADD PMC10035756__F5 State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer APC RELA SMO CTNNB1 PMC3233626__F5 NIRF interaction network CDC2 HDAC1 TAF1 CDK6 PCNA CDK2 TAF1B TBP ING1 CDK4 PMC8596927__F12 TRPV4-induced Müller cell gliosis and TNFA elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NFKB pathway STAT3 GFAP PMC5587602__F7 Sodium butyrate has context-dependent actions on dipeptidyl peptidase-4 and other metabolic parameters IL16 DPP4 IL1B PMC3313666__F7 Outline of the mevalonate pathway CDC42 RHO PMC4822123__F8 Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice BMP15 STAT3 MTOR NOTCH2 GDF9 RAC1 NOBOX PMC9528772__F8 Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1‐Drp1 signalling pathway ADD1 ROCK1 SIRT6 PMC3726964__F3 Regulation of the EMT Pathway and Tec kinase signaling in Calu-6 compared to U1752 FAS SMURF1 HMGA2 ID2 FOXC2 TLR4 SMAD4 ZEB2 ARHA FOS PMC4037911__F1 Bid can be activated by multiple proteases in response to a variety of pathophysiological signals MTCH2 BAX FADD PMC8997759__F1 Liquid–Liquid Phase Separation in Cancer Signaling, Metabolism and Anticancer Therapy TBK1 CGAS IRF3 NF2 PMC5244366__F1 Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway EGF EGFR BRAF PMC305600__F7 An EGF receptor/Ral-GTPase signaling cascade regulates c–Src activity and substrate specificity STAT3 EGFR SHE SRC PMC6975143__F1 Unfolded protein response (UPR).Under normal conditions PERK, IRE1, and ATF6A are sequestered in an inactive state in the ER via their associations with BiP ATF4 EIF2A XBP1 PMC8989153__F1 Heterogeneous Causes of Cushing Syndrome Resulting From Primary Macronodular Adrenal Hyperplasia (PMAH) TRO HTR7 KDM1A ARMC5 AVPR2 HTR4 MC2R LHCGR GIPR PMC9461655__F9 Novel methylated cation channel TRPM4 inhibited colorectal cancer metastasis through Ca2+/Calpain-mediated proteolysis of FAK and suppression of PI3K/Akt/mTOR signaling pathway ORAI1 STIM1 MMP2 MMP9 MTOR PMC4031445__F2 Signal transduction by prostaglandin receptor EP2 PFN1 EGFR GSK3B SRC CTNNB1 PMC11907984__F2 Main function of CBXs family proteins ME3 CBX2 CBX6 CBX4 PCGF2 CBX1 SUV39H1 PMC3047603__F3 CYP17 inhibitors for prostate cancer therapy HSD3B2 HSD17B3 CYP11A1 RDH5 OMA1 PMC11907984__F3 Details of CBX members regulate Wnt/Beta-catenin, Hippo, MARK signalling pathways in tumours and mechanism CBX2 HMGA2 NCAPG CBX4 CBX1 CBX8 CBX3 WTIP AKR1B10 PDE4B KRAS CTNNB1 FGFR2 BMP4 GC CCND1 PMC11907984__F4 Details of CBX members regulate PI3K/AKT/mTOR, NFKB signalling pathways in tumours and mechanism PIK3CA CBX2 UBC EGFR PIK3CD EZH2 CBX8 PTEN MTOR RNF26 IRS1 PSMC4 PC FGFR3 S100A9 CCND1 PMC9224557__F5A Key Immune-Related Genes in the Heart Following Burn Injury MME STAC WAS CD14 POLI MIP LBP PMC11907984__F5 Details of CBX members regulate TGFB, Notch, HFI-1, P53/P21, E2F1/BIRC5, Rho GTPase, PRDM1/c-FOS signalling pathways in tumours and mechanism HEL113 TGFB1 HMGA2 EGFR CBX4 CBX8 RHO WDR5 TGFBR1 KPNA2 HEL25 WNK2 MMP2 PC CCND1 UBC PRDM1 YBX1 CBX3 VEGFA ITGB3 RAC1 ANGPTL4 SMURF2 ARHGAP24 PMC8739678__F3 FcG receptors in HER2-targeted breast cancer therapy HTRA2 CAD TREX1 PMC5667541__F2 Protein O-GlcNAcylation: emerging mechanisms and functions OGA TPR OGT GNPNAT1 CD2 SIN3A PGM3 PMC4882719__F2 Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy BAX EGFR PTEN PMC11354872__F2 Short chain fatty acids (SCFAs) and antioxidant roles against CRC development NLRP3 HEL-S-62p KEAP1 C2 PMC7012898__F1 Upstream and downstream targets of the TOR Complex (TORC) in plants RFWD2 RPS6 EIF3S3 PMC5667541__F4 Protein O-GlcNAcylation: emerging mechanisms and functions OGA OGT KCNQ3 ULK1 AgRP PMC9488999__F1 Is mitochondrial dysfunction a driving mechanism linking COPD to nonsmall cell lung carcinoma? PINK1 MAVS NLRP3 IL1B PMC6256059__F1 Notch receptor maturation, ligand dependent and independent activation pathway and targetable steps ADAM17 ADAM10 FURIN PMC4558162__F1 OVOL guides the epithelial-hybrid-mesenchymal transition STAT3 SMAD4 BMP7 PMC3772387__F8 Recruitment of FLNa, IQGAP1 and RacGAP1 to active B1 integrin regulates Rac1 activity IQGAP1 FLNA RAC1 PMC4677908__F6 Genomic and transcriptomic features of central carbon metabolism in C HEL107 RPE PC ASNS PMC3461903__F2 New molecular insights into peripheral T cell lymphomas HRAS STAT3 STAT1 PDGFRA PDGFA GRB2 JAK1 TYK2 PMC8228270__F1 HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response UBE2L6 IRF9 ISG15 JAK1 TYK2 PMC8228270__F2 HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response UBE2L6 ISG15 PMC4821889__F8 Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGFB signalling pathways LATS1 LATS2 SIAH2 PMC5514964__F6 Regulatory functional territory of PLK-1 and their substrates beyond mitosis CDC2 GTSE1 RAD51 C13orf34 BRCA1 TOPORS BRCA2 WEE1 MYT1 PLK1 PMC6769927__F4 The different Transforming Growth Factor B (TGFB) family members on articular cartilage biology and osteoarthritis (OA) development PRG4 STAT3 SMAD1 ALPL DKFZp781O1323 SOX9 SMAD2 ADAMTS5 MMP3 IL6 RUNX2 PMC6769927__F2 Transforming growth factor B (TGFB) family SMAD-dependent signaling BMPR2 SMAD9 ACVR2B SMAD1 ACVR2A TGFB1 DKFZp781O1323 SMAD2 BMP7 NODAL RUNX2 GDF5 TGFBR2 BMP6 SOX9 BMP2 PMC6769927__F3 Transforming growth factor B (TGFB) family SMAD-independent signaling MAP3K7IP1 SP1 SHC1 MAPKAPK2 AK1 ATF2 GRB2 CEBPB UNK PMC3907751__F1 ROS generation and its effect on angiogenesis RAC1 MPO PMC7247360__F1 Impact of Transcription Factor Prospero Homeobox 1 on the Regulation of Thyroid Cancer Malignancy PIK3CA PI3 PAX8 BRAF PTEN RET PMC3415277__F6 Identification of multiple disrupted components in a biological pathway MAPK1 EGF CASP9 BAD TGFA RAF1 SHC1 RASSF1 EGFR DUSP4 MYC KRAS TG PLCG1 SOS2 PRKCA MUC1 ERBB2 RRAS MAP2K1 GRB2 CCND1 PMC2904169__F1 Hypoxia-inducible factor (HIF)-2 regulates erythropoietin (EPO) GATA2 EPO PMC4234705__F2 Eph Receptor Tyrosine Kinases in Cancer Stem Cells EPHA2 EPHA3 MTOR PMC8533163__F8 Bacillus amyloliquefaciens SC06 Induced AKT–FOXO Signaling Pathway-Mediated Autophagy to Alleviate Oxidative Stress in IPEC-J2 Cells BAX ATG12 FOXO3A ATG14 BCL2 ATG5 SIRT1 PMC4561380__F6 Unveiling the metabolic potential of two soil-derived microbial consortia selected on wheat straw HEL107 GHB2 PMC4991449__F8 Adipocytes WNT5a mediated dedifferentiation: a possible target in pancreatic cancer microenvironment SFRP5 STAT3 ROR2 IL6 IL6R PMC3207123__F1 A view of CD133 expression as it relates to variety of normal tissue and cancer stem cells HIF1A MTOR CXCR4 PMC8486596__F2 Cellular senescence in cancer: from mechanisms to detection CDC2 CDKN2A ATR CDK6 CDK2 ATM MDM2 MTOR MYC CDK4 PMC8479832__F1 Purinergic signaling in the modulation of redox biology MPO PMC9684343__F7 CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor FASN PC HEL-S-26 PMC8479832__F2 Purinergic signaling in the modulation of redox biology NLRP3 CASP3 IL1B PMC12019274__F1 Effect of aberrantly expressed long non-coding RNAs on cell death in different modes RIPK3 CDKN2A GSDMD AGO2 NLRP3 MLKL GPX4 SLC7A11 SIRT1 PMC4324544__F8 Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model BAD FAS FADD PMC8992594__F4 Emerging actionable targets to treat therapy-resistant colorectal cancers IDO1 RELA CTLA4 VEGFA LAG3 PMC9688455__F1 PARP Inhibitors in Cancer Immunotherapy: Potential Friends to Immune Activating Molecules and Foes to Immune Checkpoints CD80 ATR CHEK1 ATM PMC8992594__F2 Emerging actionable targets to treat therapy-resistant colorectal cancers ERBB3 CASP9 EGF BAD HGF TGFA EPHA2 EGFR GSK3B BRAF ERBB2 PTEN PMC8992594__F3 Emerging actionable targets to treat therapy-resistant colorectal cancers TGFBR2 BRAF VEGFA ACVRL1 ANGPT2 PMC3880999__F1 Molecular details of BAFF/BAFFR-mediated activation of NFKB2 signaling pathway FBXW7 RELB TRAF3 TRAF2 PMC7892976__F2 Se transport across blood–brain barrier (BBB) and blood–cerebrospinal fluid barrier (BCB) HEL-S-134P SELENOF LRP8 GPX4 SELENOP SELENOW PMC7568161__F1 Proposed pathway underlying rh-CSF1 provided neuroprotection UCP2 CSF1 PLCG2 PMC153613__F4 Highlights of key changes in cell cycle, differentiation, and metabolism-related transcripts DUSP3 CCND2 MAPK9 RPS6KA3 NFATC3 BCL6 CDK4 PMC7469991__F1 Common signaling pathway with miRNAs involved in the different malignant phenotypes of gastric cancer BMI1 STAT3 SLC34A2 YES1 POU2F2 SUFU SMAD4 PTEN ROBO1 YAP1 CTNNB1 PMC6035417__F1 Molecular mechanism of apoptosis and necroptosis RIPK3 TRADD MLKL RIPK1 PMC3545927__F6 High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome DVL1 SMAD1 DKFZp781O1323 ALK SMAD2 APC GSK3B SMAD4 ATF2 GATA4 FURIN PMC9563506__F9 PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages CDH2 PCSK9 CXCL9 ARG1 MIF MMP9 CD163 IL1B PMC6953059__F1 Steps involved in the biogenesis and functions of miRNAs RAN DGCR8 PMC6799833__F7 Potential mechanisms of fluoxetine in the remission of AD HDAC1 SIN3A APP BDNF PMC9664042__F1 Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1B GSDMD IL33 IL1B PMC7614756__F6 Effect of NRP1 on the TGFBR2-VE-cadherin pathway in regulating adherens junctions and inflammatory responses CRP CXCL12 TGFB1 CSF1 SELL IL12A CXCL1 NRP1 CXCL16 CXCL2 IL6 CCL5 CCL2 CSF3 TGFBR2 CXCL11 HMOX1 IL16 IL11 SIRT1 SELP PMC6337329__F6 Proposed model of molecular interactions and clustering analysis CDC42 PARVA RSU1 ROCK1 HEL-S-28 ARHA MTOR PMC4631757__F10 The interaction between corneal stroma (canonical Wnt signaling) and epithelium (Bmp4 signaling) during mouse corneal development SMAD1 DKFZp781O1323 BMP4 LRP5 LRP6 TEF CTNNB1 PMC5496044__F1 Schematic diagram of domain structure for LRP1 and LDLR EGF LDLR FURIN PMC6799833__F4 Autophagy pathway RHEB ATG3 TSC1 ATG16L1 ATG12 ULK1 VMP1 UVRAG AMBRA1 ATG14 ATG5 PMC9523483__F2 OncomiRs as noncoding RNAs having functions in cancer: Their role in immune suppression and clinical implications MICA MICB TNF CTNNB1 PMC5514916__F8 NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway ACVR1 SMAD4 MDM2 PMC4071053__F2 Molecular network generated by Ingenuity Pathway Analysis (IPA) of highly significant gene changes in human RPE cells after in vitro stimulation with AGE (10 μg/mL) IFIT1 PNPT1 IFIT3 IFIH1 DTX3L IFIT2 SP110 RSAD2 CCL5 XAF1 ANGPTL1 CXCL11 IFNG STAT1 USP18 MX2 EIF2AK2 PMC4071053__F3 Interferon Signaling Pathway identified by Ingenuity software IFNG BAX STAT1 STAT2 PSMB8 IRF9 IFIT3 PIAS1 IRF1 TAP1 IFI35 PMC10483736__F1 Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA) CTC1 STN1 TERT TEN1 POT1 TPP1 PMC12017889__F1 Reported regulatory mechanisms of ferroptosis FTH1 FTL STEAP3 LPO GPX4 LPCAT3 FACL4 SLC7A11 MTOR PMC6390333__F1 De novo biosynthesis of various aromatic compounds derived from the SHK and aromatic amino acid biosynthesis pathway TH FH PTS SMO PAH CS DDC STS PMC12017889__F3 Relationship between ferroptosis and immunity IFNG STAT1 HMGB1 SLC7A11 PMC8555666__F10 Differential Association of Free, Conjugated, and Bound Forms of Polyamines and Transcript Abundance of Their Biosynthetic and Catabolic Genes During Drought/Salinity Stress in Tomato (Solanum lycopersicum L.) Leaves SOST ARG2 PMC5342554__F8 NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/Beta-catenin signaling pathway in hepatocellular carcinoma NTS APC RHO GRB2 CTNNB1 PMC6271612__F1 The molecular mechanism behind mitophagy after stroke MFN1 MFN2 BNIP3 PMC3976614__F1 Modulation of mitochondrial dysfunction by the PINK1/PARKIN pathway PINK1 MFN2 PMC8545469__F7 T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese TBK1 CGAS IRF3 PMC6571408__F9 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of MAGE A11 in patients with esophageal squamous cell carcinoma (ESCC) MTOR TNF PMC3676391__F1 Saccharomyces cerevisiae Assay System to Investigate Ligand/AdipoR1 Interactions That Lead to Cellular Signaling OSM APPL1 ADIPOR1 PMC6796858__F10 Cortical branched actin controls the G1/S transition HEL-68 ARPIN CORO1B ARPC1B PMC7464279__F7 Synergistic effect of cyclopamine and rapamycin SUFU SMO GLI3 PMC8234594__F1 Epithelial–Mesenchymal Transition Associated with Head and Neck Squamous Cell Carcinomas: A Review FOXA1 GSK3B TRAF1 TRAF3 TNF CCND1 TRAF2 CTNNB1 PMC8728363__F6 Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer CD40 CD24 CCR5 CCR2 CD47 PMC7226088__F2 Regulatory signaling pathways in MDSC development and functions RIPK3 STAT3 STAT1 COX2 IL16 S100A8 ARG1 IL6 JAK1 CCND1 MYD88 PMC9374671__F1 Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD consumers mediated by Twist2 NNMT NRK CYP2E1 SIRT1 PARP1 PMC3359728__F3 Regulation of homeostatic AMPAR trafficking and turnover CDH2 ARC BDNF CTNNB1 PMC1383482__F1 Tumor Necrosis Factor by Microbial Pathogens BAX TRADD TNF FADD PMC8249562__F4 Mitochondrial Hsp90 TRAP1 and Alzheimer’s Disease CDH2 STAT3 BAX PHB2 GZMM PINK1 EBP HSF1 PMC8816937__F7 Schematic diagram showing that the ETV4 functions in HCC metastasis MMP7 ETV4 DVL2 MYC CTNNB1 PMC6477167__F1 Interplay between HPV-infected keratinocytes and the local immune microenvironment critically influences cervical carcinogenesis.HPV suppresses inflammatory signaling in the host keratinocyte IL18 CCR7 CCL2 CCL20 IL1B PMC7734179__F1 Cytosolic DNA sensing pathways GSDMD TLR9 AIM2 MTOR TRAF6 MYD88 PMC4662454__F4 Targeting cancer by binding iron: Dissecting cellular signaling pathways STAT3 BAX SMAD2 SMAD4 ATF2 GRB2 SRC PMC4662454__F5 Targeting cancer by binding iron: Dissecting cellular signaling pathways CDH2 SMAD2 APC GSK3B SMAD4 LRP6 ARHA CTNNB1 PMC3378977__F1 Summary of the suggested mechanism for the regulation of MMPs and TIMPs in the paracrine interplay between SCC-25 cells and fibroblasts CD44 TIMP3 PMC4220839__F2 Cytosolic DNA recognition pathway for IL-1B production RAD50 AIM2 IL1B CARD9 PMC9170611__F4 Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer TSC2 RICTOR TSC1 LRP5 LRP6 PTEN CTNNB1 PMC9292562__F3 Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing TRPM2 NAMPT FOXP3 IL1B PMC7460532__F1 Phosphatase and tensin homolog (PTEN) signaling pathway and its interactions C2 PTEN MTOR PMC9292562__F4 Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing TPH1 NAMPT AHR SIRT1 PMC9292562__F2 Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing VIT NRK NAPRT SARM1 HEL-S-90n NAMPT PMC10779434__F2 The actin cytoskeleton within the foot processes CDC42 ACTN4 CD2AP SSH1 IQGAP1 ARHA TRPC6 RAC1 PMC7554583__F1 Mitochondrial stress responses in cystic fibrosis BAX PINK1 PAF1 ATF5 CLPP BCL2 PMC7554583__F2 mtDAMPs in cystic fibrosis Under stress, mitochondria generate and/or release immunogenic molecules, named mitochondrial damage associated molecular patters (mtDAMPs), that influence significantly the inflammatory response in CF lung disease NLRC4 VAPB ATF5 NLRP3 MCU PMC3743096__F4 Signal integration by mTORC1 coordinates nutrient input with biosynthetic output RHEB RUVBL1 RUVBL2 ATF4 EIF2A VHL PMC2938197__F1 Predicted hydroxy/hydroperoxy wybutosine biosynthesis pathway and domain architecture of key enzymes involved in its synthesis TYW3 TYW1 PMC5707548__F1 ATM (ataxia telangiectasia mutated)-mediated DDR (DNA damage response) signaling pathway BRCA1 RNF168 H2AX RNF8 ATM MDC1 PMC5535871__F5 Functional overview of ANRIL and pathways PRC1 ATM IL6 PMC4698399__F8 Processes responsible for the synthesis, trafficking, and degradation of membrane proteins EHD2 EHD3 RAB10 RAB17 RAB7B RAB7A EGFR EEA1 LAMP2 CASK DENND4C M6PR EHD1 PMC8286837__F1 Hypoxia activated UPR and DDR pathways ATR ATM ATF4 MTOR EIF2A XBP1 PMC4384293__F2 Paradoxical roles of autophagy induced by the tumor microenvironment during different stages of tumor development TSC2 FOXO3A BNIP3 ATF4 BNIP3L EIF2A PMC4548922__F2 Decreased fatty acid oxidation contributes to CKD progression TGFB1 CD36 PMC11763227__F7 FGF19 working model FGF8A CYP8B1 CYP7A1 FGFR4 PMC4986275__F4 Representation of the top Canonical Pathways, Functional Annotations and Upstream Regulators detected upon analysis of target genes and their co-regulated genes IL15 STAT3 FAS TIMP1 TGFB1 CLEC7A C3AR1 EGFR TNLG7A CCR5 HLA-DOA GNG12 IGFBP4 PTPRC HLA-DPB1 CCL5 IFNG ACTA2 CSF2RB MHC2TA TLR8 IL10 LCP2 ID2 IL13 IL10RA TNF ID3 TLR3 PMC8197124__F2 Crossroads between Host Copper Metabolism and Influenza Infection ATOX1 CCS SLC25A3 ATP7B COX17 ATP7A PMC5983675__F2 Tumor necrosis factor receptor signaling in multiple sclerosis IFNG CXCL12 PDGFRA LIF TNF PMC5963198__F4 Model of miR155 activation in BMDMs exposed to C SYK SRC PMC11621778__F9 Multi-omics co-analysis STAT3 SMAD1 NMBR ADRA1D SMAD2 GBP4 GABRB1 SLC27A1 GRM4 SPTLC2 WDR37 SPHK2 NPFF ADRA2B LAX1 USP18 COL4A2 COL4A1 ADORA2B ADAM8 TRIB3 RAB38 SEMA7A HEPACAM P2RX7 VIP FAT10 PPP2R2C SNAI2 IRF7 COL27A1 HAS1 TRH TGFB1 CD36 HEL-S-62p SPHK1 DHX58 PCK1 EEF2K COL1A1 ZBP1 ISG15 CAD COL1A2 IRGM BMP7 IL6 NCOA1 MKX CREBBP PMC2806892__F1 Methionine metabolism in vivo HEL-S-61p PMC11763227__F4 FGF19 alleviates LPS-induced hepatocytes apoptosis associated with AMPK activation in vivo and in vitro FGF8A FOS PMC5516800__F3 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? MTHFD1 PHGDH SHMT1 PSAT1 PMC5516800__F1 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? PFKFB1 FAS PFKFB4 HEL-S-133P HK2 PFKFB2 LDHB ALDOB HEL-S-68p F2 HEL-S-162eP GCK HEL-S-87p PMC3055447__F4 A schematic diagram of pyramidal cells (triangular) and GABAergic interneurons (square) within the trisynaptic pathway of the hippocampus PNN GCA HEL-S-11 PMC5516800__F2 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? FAS HK2 PMC5516800__F5 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? FAS PFKFB4 HEL-S-133P HK2 BRAF LDHB MYC KRAS PGAM1 ALDOB HEL-S-68p F2 HEL-S-162eP HEL-S-87p SRC PMC5516800__F6 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? PFKFB1 FAS PFKFB4 ALDOB HEL-S-133P F2 HK2 FBP1 PFKFB2 LDHB HEL-S-87p PMC4513218__F1 Part of the tamoxifen metabolic pathway CYP2B6 CYP2C19 CYP2C9 CYP3A4 PMC8468752__F2 Pharmacogenomics Variability of Lipid-Lowering Therapies in Familial Hypercholesterolemia UGT1A1 ABCG8 ABCG5 ABCB11 CYP2C8 ABCG2 CYP3A4 ABCB1 PMC4279797__F1 Pharmacology network-based drug repurposing for CMT1A disease GAL IGF1 PENK PMP22 TRPV1 BCL2 PDYN EGR2 SRC FLNA PMC8032975__F2 Lipoproteins and their three different metabolic pathways APOC2 LPL MTTP APOE PLTP HEL-S-70p PMC8468752__F1 Pharmacogenomics Variability of Lipid-Lowering Therapies in Familial Hypercholesterolemia PCSK9 LPL ABCG5 ANGPTL3 HMGCR APOE ABCG2 PMC7180987__F1 Effects of growth hormone on adipose tissue: old observations, new mechanisms TG PLIN1 G0S2 GHR PMC7989705__F2 Solute carriers (SLCs) associated with PDAC cell proliferation, angiogenesis, invasion, and metastasis CD44 STAT3 SLC3A2 LATS2 TP53INP1 SLC7A11 IL6 MTOR PMC7920467__F1 Ceramide de novo synthesis pathway CERS3 CERS5 CERS1 PMC3944264__F6 Proposed model for miR-542-3p-mediated suppression of osteoblast proliferation and differentiation SMAD1 DKFZp781O1323 BMP7 RUNX2 PMC7923474__F4 Label-free proteomics uncovers SMC1A expression is Down-regulated in AUB-E EIF2S1 ITGB1 MCM3 SKP1 SMC1A LMNB2 YWHAZ PMC7884645__F2 NLR in eXile: Emerging roles of NLRX1 in immunity and human disease NLRX1 CGAS MAVS ATG16L1 ATG12 TUFM IRF3 IRF7 TRAF3 TRAF6 ATG5 PMC7989705__F3 Solute carrier (SLC) expression is associated with cell death SLC3A2 PAF1 GPX4 SLC7A11 HEL-S-298 SLC31A1 PMC2612524__F7 A potential model for contributions of F-BAR-containing adaptor proteins and PTKs in regulating FcɛRI signaling during internalization SYK FER FES LYN PMC4872729__F2 Understanding the role of the kynurenine pathway in human breast cancer immunobiology TDO2 ID2 HEL-S-90n KYNU KMO ID1 PMC6274245__F5 Upstream signal transduction pathway leading to activation of canonical p50/p65 NFKB upon stimulation by tumor necrosis factor (TNF)A (see text for details, scheme realized with ScienceSlides) MAP3K7IP1 TRADD TNF TRAF2 PMC6274245__F6 Regulation of posttranscriptional modifications of NFKB and histone H3 with and without TNFA stimulation HDAC1 HDAC2 SIRT1 SETD6 PMC3226194__F7 An integrated pathway model involving FOXA1 in breast cancer CYP2C18 FOXA1 RAD51 BRCA1 BRCA2 ATM EPHX2 PMC5976735__F3 Main signaling pathways involved for 12 miRNAs differentially expressed after exercise from EVs purified from rat’s serum POR LAT MAK PMC6738443__F4 Modular network regulation map of gene-related ncRNA/TFs TF CD40 FUS BAX REST ELL IL6 TUG1 TNFSF14 MIA ACSL1 NR1C1 MME MIIP ADAM17 RELA WAS LDLR APP ATF4 MIP CPT1A PMC10889827__F3 Ihh signaling plays a critical role in periosteal bone biology and shows complex interaction with other molecules SMAD1 DKFZp781O1323 SUFU BMP2 IHH SMO PMC10889827__F4 Wnt signaling has important indirect as well as direct effects on PDCs SMAD1 DKFZp781O1323 APC GSK3B BMP2 IHH WNT7B CTNNB1 PMC10889827__F1 BMP signaling represents a fundamental signaling profile in periosteal effects BMP6 WNT3A BMP4 BMP2 PTH PMC10889827__F2 PDGF signaling mediates periosteal activation and blocks BMP2-induced osteogenesis SMAD1 DKFZp781O1323 BMP2 PMC8005457__F7 Pentamethoxylated flavone from Glycosmis ovoidea promotes apoptosis through the intrinsic pathway and inhibits migration of MCF-7 breast cancer cells BAX BCL2 PARP1 PMC6203329__F2 Cellular oxidative and genotoxic stress responses converge on the AMPK/mTORC1 pathway RHEB TSC2 TSC1 ATM PMC7408280__F3 Transcriptional modulation of the inflammatory response in PD TH COX2 MAF IL6 IL1B PMC9636152__F1 DNA damage signaling pathway BARD1 BRCA1 RNF168 H2AX RNF8 ATM RIF1 MDC1 PMC4253418__F7 Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer TF APC GSK3B RYK WNT3 MTOR CCNB1 SRC CCND1 CTNNB1 PMC5059721__F6 Carbon Ion-Irradiated Hepatoma Cells Exhibit Coupling Interplay between Apoptotic Signaling and Morphological and Mechanical Remodeling BAX C2 DIABLO PMC6539048__F5 Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence—A Transcriptomic Study MMP14 TXNIP MCL1 SMAD4 VCP CCND2 INSR FST KLF10 EGR1 ID2 IHH TGFBR3 TACR3 VEGFA PHIP FOS ID1 ANGPTL4 HEL-S-112 MAP3K1 BTG2 UBE2B ECE1 CHRDL1 EDNRA HSPA4 IGFBP7 EGR2 PMC6539048__F6 Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence—A Transcriptomic Study MMP14 EGR1 ID2 SMAD4 IHH VEGFA FOS ID1 BTG2 INSR KLF10 IGFBP7 EGR2 PMC9530954__F12 Identification of the molecular subgroups in Alzheimer's disease by transcriptomic data SYN2 SALL1 RPL35 HINT1 ANKRD40 FGF12 RPL18 BRD7 RAB6B MAPK9 MYLIP VPS35 ATP6V1C1 RBM17 TRIM8 CPM PRELP ATP6V0B PHF10 AHNAK METRN TAF10 PMC5616168__F13 Schematic diagram for the ADTRP signaling pathway CAD PIK3R3 ADTRP APOB PMC6600571__F1 Skeletal muscle insulin signalling MTOR IRS1 PMC6478619__F1 Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif is a point of convergence in signaling pathways LATS1 BIRC5 LATS2 RICTOR IGF1 EGFR CXCL5 RHO AREG KRAS IRS1 PMC9013714__F7 Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway EGFR TNF IL1B PMC8080681__F2 Aberrant HNF4Alpha-related cell signaling pathways in cancer STAT3 IL1R1 NR2A1 SMAD2 GSK3B TCF4 CTNNB1 PMC6760925__F5 Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations GAA OGT AANAT MTNR1B ASMT PMC554120__F8 The inhibition of Myt1 in the meiotic and mitotic cell cycles in Xenopus MOS MYT1 PMC7072214__F5 Phosphatidylinositol 3-kinase (PI3K) signaling pathway and signaling outputs BAD CDK6 SGK1 BCL2 CCND1 CDK4 PMC7072214__F4 Apoptotic signaling pathways with the reported interaction of Rab proteins BAX BCL2 FADD PMC3742358__F3 Pathway of nucleotide excision repair and translesion synthesis XPA PCNA UVSSA XAB2 PMC5342378__F8 PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer CDH2 PAX3 CDK6 GADD45A ZIC1 CCND1 CDK4 PMC12012940__F1 Identification and characterization of the core HPARBP network RBMX RAN DNCL1 KHDRBS1 TCERG1 DDX42 YARS2 FXR1 FIP1L1 SNRPD1 U2AF2 RPS3 DENR SNRPB2 UBAP2L NPM1 RBM12 DYNC1H1 EIF5B CPSF6 NCBP2 TRMT1 GTPBP4 RCL1 PRPF3 EWSR1 SNRPG EEF1E1 SNRPA ILF3 SSB PTBP1 RUVBL1 POLDIP3 PMC2582888__F8 Two parallel pathways are required for Abl-dependent cell detachment LPA EPHA2 ROCK1 CRKL ARHA PMC7206374__F4 Potential regulatory modeling of miR126-3p and PIK3R2 in porcine GCs (pGCs) INSR PIK3R2 PMC8144021__F1 Precision Medicine for Paediatric Severe Asthma: Current Status and Future Direction IL25 TSLP IL33 PMC5613059__F1 Frequent genetic alterations of PI3K/mTOR signaling pathway in HNSCC RHEB PIK3CA TSC2 RICTOR TSC1 EIF4EBP1 EGFR PRKAA2 PIK3CD PTEN PRKAA1 EIF4E PMC12012940__F7 The underlying molecular mechanisms of the specific HPARBPs and their common binding targets regulating the Wnt signaling pathway RNF43 U2AF2 PTBP1 LRP5 ZNRF3 LRP6 ILF3 GPR49 NCBP2 CTNNB1 PMC8719641__F3 New Insights Into the Biosynthesis of Typical Bioactive Components in the Traditional Chinese Medicinal Fungus Cordyceps militaris PTS PMC5874430__F10 Ingenuity Pathway Analysis (IPA) diagram of the cell cycle control pathway MAX BMI1 NRG1 ATR SIN3A PAK1IP1 SMAD4 CDK2 MDM2 SUV39H1 PMC5649056__F3 Canonical Wnt signaling and bone remodeling LRP5 LRP6 CTNNB1 PMC7072285__F6 Putative inhibitory effect of 8-HD in the IRF-3 signaling pathway TBK1 TIRAP TLR4 IFIT1 IRF3 TRAF3 CXCL10 MYD88 PMC8501049__F10 CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling RYR2 MFN2 MCU PMC2928711__F9 Leptin upregulates VEGF in breast cancer via canonic and non-canonical signaling pathways and NFKB/HIF-1A activation STAT3 SP1 PMC8938628__F1 Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting Beta-catenin/TCF4 signaling pathway BCL9 APC GSK3B LRP5 LRP6 CTNNB1 PMC8537064__F1 Molecular Mechanisms of the SLC13A5 Gene Transcription ACLY CIC SLC13A5 MTOR PMC5355165__F1 Crosstalk between microRNAs and the Wnt/Beta-catenin signaling pathway in cancer BCL9 APC CCND1 IGF2 CTNNB1 RUNX3 PMC4233297__F2 Summary of myocardial cellular effects and the injury response induced by anthracyclines BAX FAS TLR4 NFAT5 BRCA2 CASP3 MTOR GATA4 PMC5828413__F3 PPI network of CAD genes WDR12 HS3ST2 MYO1D CYP24A1 RNF103 NLRP11 NMT1 TLL1 ZNF610 EVI1 ZNF652 HIF1A GOSR2 ALK DAP SMARCA4 CTIF PPP2R2C MSRA MAP4 MIA FIGN CSK FES HFE HNF1A ATXN2 HEL-S-15 RPTOR CYP17A1 TET1 PCSK2 TXNDC11 MIA3 ADARB2 SYNE1 PTPRG TUBA1C NFIA IMMP2L GNG2 ARHGAP42 PLCE1 MACROD2 TNS3 KPNA3 MAGI1 DIPLA1 ARL15 RBM19 NAV2 PNLIPRP3 NALCN RASD2 DISC1 DNAJC5B PMC4490154__F1 What do we know about the cardiac benefits of exercise? CITED4 NRG1 IGF1 PTEN SET PMC5513686__F1 Principal effects of chronic alcohol abuse on anabolic and catabolic mechanisms that maintain skeletal muscle mass IGF1 MTOR IRS1 PMC8401259__F5 Immune Response and Apoptosis-Related Pathways Induced by Aeromonas schubertii Infection of Hybrid Snakehead (Channa maculata♀ × Channa argus♂) BAX CASP9 BAD TRADD CASP12 TNF MYD88 CASP6 CASP3 FES ATM TRAF2 FADD PMC3069685__F2 An Activating Transcription Factor 5-Mediated Survival Pathway as a Target for Cancer Therapy CREB3L2 ATF5 FRS2 PAK1 MCL1 PMC8401694__F1 Emerging Role of Nutraceuticals in Cardiovascular Calcification: Evidence from Preclinical and Clinical Studies TRPM7 SMAD1 TNFAIP3 BMP2 GPR39 RUNX2 CTNNB1 PMC8401694__F2 Emerging Role of Nutraceuticals in Cardiovascular Calcification: Evidence from Preclinical and Clinical Studies BMP2 GPR39 ENPP2 RUNX2 PMC5828413__F2 Coexpression network of CAD genes and metabolic pathway genes WDR12 HS3ST2 CYP24A1 DDOST DGKB NUDT5 TYMS COX6A2 HS6ST3 NMRK2 NDST3 C5orf47 CA3 SEZ6L ITPKA PAPPA2 PDXP CKMT2 FUT9 MGAT2 SYT2 SCD5 GAD2 DAP GGH GLB1 PPP2R2C PYGM ACSL6 POLE2 MAP4 NMNAT2 ADSL RPE PAICS PGAM2 ENO3 FBP2 ADCY1 AGPAT4 DHFR MYH7 UMPS CYP21A2 HSD3B2 CYP17A1 RRM1 RRM2 PCSK2 HEL-S-70p PLCE1 PNLIPRP3 NALCN RASD2 PMC6113562__F3 Regulation of inflammatory arachidonic acid (AA) derivatives after Leishmania infantum or Leishmania donovani infections NAT2 PMC4571721__F5 Chemokine signaling pathway map created based on KEGG pathways CRK FAS JAK3 ITK ARHA GRB2 SHE PMC2810291__F6 Endonuclein functions STAT3 ARHA SSB PMC8560782__F1 Urinary excretion of epigenetically modified DNA as a marker of pediatric ALL status and chemotherapy response UNG SMUG1 MBD4 TDG PMC7685174__F1 Balance of angiotensin (Ang) II and Ang-(1–7) in the renin-angiotensin system (RAS) TOMT ACE2 PMC2861953__F2 Altered signaling pathways and mouse models of thyroid cancer TSHR NTRK1 PTEN RET PMC4967202__F2 MMP-9 signaling in the left ventricle following myocardial infarction SP1 CD36 IL16 CCR2 PLG IL1B PMC8131382__F7 Hypothetical model for the regulation of cell proliferation and tumorigenesis by the Notch3ICD/PTEN axis PTEN MTOR NOTCH3 PMC6743293__F2 Molecular mechanisms of KLF15 in renal fibrosis and mesangial pathology KLF15 CDK2 PMC8569436__F1 STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications GAA STAT3 HIF1A MYC PMC8214965__F5 姜黄素通过Wnt/Beta-catenin信号通路诱导人晶状体上皮细胞的凋亡和细胞周期阻滞 CDC2 APC MAL CCNB1 CTNNB1 PMC12043473__F2 Conversion from normal fibroblasts (NFs) to cancer-associated fibroblasts (CAFs) involves multiple molecular mechanisms SOCS1 LPA CD44 STAT3 IGF2R EREG SMAD2 IL33 SMAD4 SKI YAP1 PMC12043473__F3 Origin of CAFs are complex, diverse, and heterogeneous STAT3 CXCL12 MSC PMC7176765__F1 Multiple Lysine methylation regulate cellular functions of p53 PRMT1 SMYD2 USP28 GIP SETD7 PMC4540601__F4 Differences in M1- versus M2-macrophage fueling reactions FAS CD36 ARG1 CPT1A PMC2997522__F2 Novel Therapies Against Aggressive and Recurrent Epithelial Cancers by Molecular Targeting Tumor- and Metastasis-Initiating Cells and Their Progenies SMO CXCR4 PMC5967272__F1 Aberrant signaling in systemic lupus erythematosus (SLE) T cells CD44 STAT3 SYK PTEN IRF4 LCK PMC8566527__F6 The mechanism of CIRT boosts anti-tumour immune responses in melanoma-bearing mice STAT3 ARG1 PMC3945331__F4 Modules identified by functional and gene expression enrichment analysis HEL113 PRMT2 PIK3R3 NFKB2 PIK3R2 WASL GSK3B PRKCZ RHO MYC TCERG1 GNB1 GNAS MYLK EZR SOST tmp_locus_29 ARHGEF12 MYH9 WAS AP2A2 STX1A NACA HTT UBB RDX NAPB DNAJB1 PFN1 FLNB SP1 MYH10 RPSA MYH1 APC DLG4 SNCA HEL-S-28 UBE2S FOS HEL114 GFAP RAPGEF2 ARHGEF1 CREBBP ARHGEF7 EP300 BAIAP2 PMC3945331__F5 Additional functional modules identified by ingenuity pathway analysis MAX RASGRF1 DVL1 ITGB4 PIK3R2 WASL AKT3 ZYX PTEN MTOR MAPK14 MYLK TXN SOST HSPD1 FYN HIPK2 INSR CLTA MDM2 HTT UBB AMPH EIF4B DNAJB1 BAG1 APC TSG101 B2M PSMD7 RPS18 DNAJC21 FOS SYMPK HEL114 AP2M1 HGS RBX1 FTL APOB CREBBP ARHGEF7 EP300 DNAJB11 PMC9102675__F2 Endothelin and RAS/ERK signaling in immunopathogenesis-related fibrosis in patients with systemic sclerosis: an updated review with therapeutic implications HRAS MTOR PMC5727330__F1 Downstream effectors of Ras pathway including Ral pathway and their biological roles CDC42 RIN1 RHO PMC5727330__F2 RalA/B effectors CDC42 RALA ARHA CCND1 RAC1 RALBP1 PMC2975924__F3 Eph/ephrin signaling regulates intestinal cell positioning and proliferation EFNB1 PI3 DVL2 DAAM1 PMC5501892__F2 Metabolic profiling of intracellular glycometabolism HEL107 HEL60 FH CS MYC IRS1 RHEB SDHA TSC2 PDHA1 HEL-S-304 RPIA HEL-S-68p OGDH SUCLG2 HEL-S-162eP HEL-S-32 ENO1 HEL-S-26 PMC5501892__F4 mRNA expression of enzymes and factors involved in glycometabolism HEL107 HEL60 PRKAG2 HIF1A CS MYC PRKAA1 HEL-S-32 HEL-S-26 PFKM FH HEL-S-133P HEL-S-30 IRS1 RHEB SDHA TSC2 PDHA1 HEL-S-304 TSC1 RPIA HEL-S-68p OGDH HEL-S-162eP HEL-S-49 RPS6KB1 SUCLG2 PRKAA2 PRKAG1 PRKAG3 PRKAB2 ENO1 PRKAB1 HEL-S-87p PMC4489427__F6 Integrated analysis of alterations in key pathways in nccRCC subtypes FH PTEN HIF1A FLCN KRAS VHL SDHD RHEB PDHX TSC2 SDHB TSC1 TFEB PDHA2 PRCC SDHC PMC5661624__F3 Redox regulation of cell–cell junctions RELA PMC6320606__F3 Schematic model depicting the proposed signaling pathway in LH/hCG-induced the resumption of meiosis NPPC BMP15 EGF COMP EGFR WEE1 NPR2 MYT1 FSHR GDF9 PMC6941304__F1 Models of Siglec-15–ligand interaction and downstream signaling CD44 SYK TRAF6 PMC4366058__F4 Mirin is an antiviral polyamide (AVP) sensitizer RAD50 MRE11A ATM PMC7160537__F7 Mechanism of TP-induced lung cancer cell inhibition via ribosomal stress initiation MDM2 RPL23 NCL PMC5661624__F4 Redox regulation of cell mobility CDC42 GSK3B PTEN ARHA MDM2 SRC RAC1 CTNNB1 PMC6190877__F1 General schematic diagram of molecular players involved in sex differentiation of gonochoristic teleost with genetic sex determination DMRT1 FOXI2 FOXL2 SOX9 AMH PMC6365663__F2 Overview of the heme biosynthetic pathway SLC25A38 SLC25A37 SLC25A28 PMC9693741__F2 Advances in neovascularization after diabetic ischemia SLIT2 ROBO1 CTNNB1 VHL PMC7810547__F2 miR-155 modulates TLR4 signaling pathway in sepsis SOCS1 TLR4 IRAK1 TRAF6 MYD88 PMC5458543__F3 Fucose metabolism pathways and variation in types of fucosylated glycans EGF SLC35C1 FUT1 FUT4 FUT8 FUT6 FUT2 POFUT4 FUT3 FUT5 POFUT2 FUT7 POFUT3 POFUT1 FUT9 PMC2727282__F7 Proposed coloboma mechanism in Lrp6-null eyes and a possible signaling network during early eye development BMP4 LRP6 TBX5 VAX2 PMC7756118__F6 The signaling pathway involving in megakaryocytic differentiation in normal and leukemic marrow AXL NPM1 PMC8238072__F1 Experimental Drugs for Chemotherapy- and Cancer-Related Anemia STAT3 SMAD2 IL6 PMC4777597__F1 The 5S RNP complex (RPL5, RPL11 and 5S rRNA) regulates MDM2-p53 in response to cellular stress RPL5 RPL11 MDM2 PMC7674854__F1 Schematic overview of insulin signaling and glucose utilization pathways in the brain MTOR IRS1 PMC7396595__F2 In the absence of co-stimulation, typically in a T lymphocyte that has not been exposed to antigen yet (naive T cell), GSK3B is constitutively active and phosphorylates NFAT2 CD80 IL10 GSK3B IL2 FOXP3 TBX21 CTNNB1 PMC12025042__F4 Non-genomic actions of Vitamin D NR1i1 STAT3 CYP2R1 DBP CYP24A1 CANX STAT2 HEL-S-269 PLAA STAT1 CYP11A1 SRC CUBN PMC6235178__F1 Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor LATS1 LATS2 PMC8012837__F1 Trop2 signaling NUMB PARP1 CTNNB1 PMC3633488__F3 Decorin’s effects on Beta-catenin and Myc stabilization by directly down-regulating EGFR and Met CIP2A EGF LRP5 LRP6 MYC CTNNB1 PMC3707615__F5 Encoding and Decoding Cellular Information through Signaling Dynamics ATF3 EGF NGF ATR TLR4 EGFR NGFR ATM MDM2 PMC4322839__F1 Negative feedback loops at the core of transcriptional oscillators MDM2 HES1 PMC8466058__F1 Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation ADAM10 HES1 NOTCH1 PMC7794676__F5 Pyroptosis on the tumor microenvironment CASP8 GSDMC CASP3 GZMA GSDMB DFNA5 PMC8833582__F5 Inflammation, Fibrosis and Cancer: Mechanisms, Therapeutic Options and Challenges STAT3 SMAD2 SMAD4 SMURF2 TRAF6 TGFBR1 PMC5405080__F11 Reactive oxygen species (ROS) maintenance by redox homeostasis FAS ATM TIGAR PMC6721595__F1 Human oligodendrocyte precursor cells (hOPCs) incorporate and metabolize nervonic acid FIG4 MOG MBP PMC3230307__F1 Autophagy regulation RHEB MLST8 TSC2 TSC1 PTEN MTOR PMC5535015__F1 NPD1 inhibits apoptosis during UOS TRADD TRAF2 FADD BIRC3 PMC9184412__F2 Dopaminergic control of Cushing’s syndrome GAL EGR1 MTOR DAO PMC3928023__F3 Wiring and firing neuronal networks: Endocannabinoids take center stage CDC42 NAPEPLD DAGLA DAGLB ARHA PMC5381981__F1 Metabolic scheme of targeted oxylipins LTB LTA LOX PMC10779100__F1 Regulation of osteoclast formation by MERTK and TYRO3 TYRO3 PROS1 ARHA MERTK PMC10779100__F2 TAM receptors and their downstream signaling pathways in osteoblasts AXL VAV2 APC GSK3B IGF1R ARHA IRS1 MERTK CTNNB1 TYRO3 IGF1 DKK1 PROS1 PMC3720736__F2 Activation of Wnt/Beta-Catenin Pathway in Monocytes Derived from Chronic Kidney Disease Patients APC LRP5 LRP6 CTNNB1 PMC6736563__F1 DSB repair pathways RAD51 PARP1 PMC5535015__F2 Up-regulation of BIRC3 transcription by NPD1-dependent c-REL expression TBK1 TRADD TRAF3 TRAF2 BIRC3 PMC9278165__F6 Comparative Transcriptome and Metabolome Analysis of Resistant and Susceptible Piper Species Upon Infection by the Oomycete Phytophthora Capsici CERK CAD PMC10758851__F1 Development and Clinical Applications of PI3K/AKT/mTOR Pathway Inhibitors as a Therapeutic Option for Leukemias RHEB MLST8 TSC2 RICTOR TSC1 BCR TTI1 CHUK PTEN MDM2 DEPTOR PMC10137778__F8 Whole Transcriptome Analysis of Differentially Expressed Genes in Cultured Nile Tilapia (O. niloticus) Subjected to Chronic Stress Reveals Signaling Pathways Associated with Depressed Growth RYR2 HRC CASQ2 PMC10137778__F9 Whole Transcriptome Analysis of Differentially Expressed Genes in Cultured Nile Tilapia (O. niloticus) Subjected to Chronic Stress Reveals Signaling Pathways Associated with Depressed Growth TUB RET PMC6633870__F7 Genes were clustered in the PPI network according to string database (genes from top 10 predicted pathways in BQG-treated group versus BLM group) BAX MAPK13 PAK4 CDKN2B MAP2 NCK2 MAP3K14 NCOR2 RARA FZD8 STH RASAL1 FES BOK RPRM GRB2 SESN2 NOTCH1 PMC7543578__F2 Sites of action of novel treatments for Graves hyperthyroidism CD40 TSHR IGF1R IL6 PMC9406657__F2 PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer TSC2 FOXO1 PTEN MDM2 PMC3372214__F1 Simplified schematic presentation of HCV genotype 2a-mediated blocking of the insulin signaling pathway RHEB TSC2 IRS1 PMC4100379__F5 The proposed mechanism underlying the inhibitory effect of MLN4924 in prostate cancer cells WEE1 CDT1 ORC1L PMC3118679__F1 The networks of factors (genes product, hormones, and metabolites) potentially involved in the regulation of milk protein synthesis in lactating bovine mammary tissue RPS6 ELF2 MTOR IRS1 EIF4E RHEB EEF2K STAT5B INSR LYZG EEF2 CSN3 LARS2 ELF5 ELF3 PMC3118679__F7 Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 60 relative to −15 d postpartum RPS6 ELL RPL23 EIF4E MAPK14 RHEB TSC2 EEF2K TSC1 GSK3A INSR LYZG RS1 EEF2 RPL4 CSN3 LARS2 SLC1A1 RPL22 ELF3 PMC3118679__F8 Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 240 relative to −15 d postpartum RPS6 EIF4E MAPK14 RHEB TSC2 EEF2K TSC1 LYZG RS1 EEF2 RPL4 CSN3 LARS2 RPL22 PMC5584741__F1 Regulation of autophagy signaling pathway VPS16 ATG10 ATG3 ATG12 UVRAG AMBRA1 ATG14 MTOR ATG5 PMC3118679__F6 Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 15 relative to −15 d postpartum RPS6 EBP MTOR RPL23 EIF4E MAPK14 RHEB TSC2 EEF2K TSC1 INSR LYZG RS1 EEF2 RPL4 LARS2 RPL22 ELF3 PMC3952558__F2 TLR4 Signaling Pathway TIRAP TLR4 CD14 IRF3 MYD88 PMC3337621__F2 Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation CD2 PI3 MAL PTEN IL6 FOXP3 MYD88 PMC9487140__F1 Review of potential medical treatments for middle ear cholesteatoma HMGB1 BTK TLR4 MIF CYLD ID1 IL6R PMC3633528__F1 Cytokine signaling cascades that influence tropoelastin transcription EGF HBEGF JUN TGFB1 TGFA SP1 EBP CDK2 CDK4 PMC6700477__F1 SHH pathway activity leading to phenotypical changes in esophageal epithelial cells SOX9 BMP4 PTCH1 SHH SMO PMC8844485__F3 Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting PARP10 HMGB1 BCR RELA ATM PARP1 IL1B PMC8617206__F4 JAK/STAT signaling pathway: from bench to clinic STAT3 STAT1 SMAD1 STAT2 IRF9 PMC6083010__F3 Ingenuity Pathway Analysis of Molecular Activation Based on Gene Expression Profiles(A) Gene expression data were analyzed by Ingenuity Pathway Analysis TIRAP MAVS NFATC2 TLR9 HIF1A SASH1 IKBKG MYD88 IL-21 IFNG STAT1 TLR4 MSC CHUK APP TLR7 F2RL1 EIF2AK2 DOCK8 NOS2 IF1IB1 SAMSN1 IFNL4 STAT2 TNK1 SYVN1 MAK FZD9 IRF1 IRF3 IRF7 IFNA2 PARP1 PAF1 TLR3 PRL RELA STAT4 JAK1 FADD PMC3006290__F1 Proposed signaling scheme for ischemic preconditioning GC GSK3B PMC3251883__F4 Proposed mechanism for VEGFA165 induced tumour growth TF CXCL9 DKFZp781O1323 TIMP1 SOS1 CREBZF SMAD4 IL7R IRF7 VEGFA IFNG RUNX1 SOS2 IL7 PMC7693908__F1 Oxygen sensing mechanisms KDM5A RGS4 VHL PMC4398619__F5 Diagram of EGFR signaling pathway showing impact of gefitinib and erlotinib on EGFR downstream signaling proteins STAT3 CBL GRB2 SRC PMC4572003__F2 Network integrating gene–metabolite associations and metabolite–metabolite correlations PEX5L NAT8 ELOVL2 NASP PYROXD2 ABCC1 ALDH18A1 KLKB1 FUT2 SLCO1B1 ACADM RNF167 ALOX12 PAH APOA5 SNAI2 GOT2 ACADS SCD APOE MBOAT7 CYP2C9 CYP2C8 HEL-S-61p GLS2 SPTLC3 PAOX FADS1 LIPC SGPP1 AHR OPLAH KNG1 GCDH SLC13A5 GADL1 ACSM2A ACSM5 NUBP2 DMBX1 DDC SCAPER SLC6A12 SLC7A6 IVD ASPG TDO2 AGXT PDXDC1 PHGDH SLC6A20 ANKH ABO ALX3 HEATR4 SH2B3 MGAM GCKR PRODH SLC16A10 PSPH GMPR HPS5 PM20D2 PMC9093043__F1 Metabolic and epigenetic landscape of HSCs and downstream progenitors CYP26B1 IDH3B PC HEL-S-26 PMC7544743__F1 MAL structure, pathway and dependent immune responses during infections SOCS1 LTA TAB3 MAL TLR9 SOCS2 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 BTK MAP3K7IP1 PMC10374606__F8 Prx II knock-down HaCaT cells are sensitive to H2O2 stimulation GSK3B PRX APAF1 PMC6447671__F8 PKZ-mediated signaling pathway ZDHHC1 IRF9 IRF3 PMC551522__F1 The Wnt signal transduction cascade APC RHO DAAM1 CTNNB1 PMC3293992__F11 Suppression of the NFKB Pathway by Diesel Exhaust Particles Impairs Human Antimycobacterial Immunity MAP3K7IP1 TLR4 TLR9 TLR8 IRF3 TLR7 IL6 PTGS2 TRAF6 IRAK4 MYD88 PMC7724953__F1 MTOR pathway RHEB EGF TSC2 TSC1 EGFR PTEN TNF IRS1 PMC4653686__F10 Proposed model of the pro-apoptotic pathway GAPDH/Siah1 in high glucose-induced human retinal pericyte apoptosis SIAH1 NONO HEL-S-162eP PMC2998162__F2 Schematics of the Hippo pathway in flies and mice KERA APP SCRIB PMC12155351__F5 Δ-9-THC-dose-dependent pathways and associated genes found in disease-specific pathways PPARG ENO2 CXCL1 FICD SELENOK BNIP3 BBC3 ZNF664 SQSTM1 LCMT1 EGLN3 PUM2 CLK1 AAK1 SEC22B TFRC JUN FOSB HK2 GCLM CXCL2 SAT2 TSC1 FTL HEL-S-68p PFKP GCLC NFKBIA PRKAB2 LCN2 PMC5712298__F1 Immunohaemostasis and infection TF TFPI MPO PMC9066210__F4 Biological roles and clinical significance of estrogen and androgen receptors in head and neck cancers FOXA1 IGF1 PMC3100780__F3 Integration of BMP, FGF and Wnt signalling at the level of Smad1 during neural induction SMAD1 LRP5 LRP6 PMC3448443__F2 Defining the Molecular Nexus of Cancer, Type 2 Diabetes and Cardiovascular Disease RHEB TSC2 PTEN MTOR PMC219066__F1 Tocopherol biosynthesis in plants GGPS1 KIN PMC7603366__F2 Dysregulated DNA damage response genes involved in pro-proliferative and apoptosis resistance characteristics of PAH-PAECs BMPR2 ATMIN UBR5 EIF2AK4 RAD51 BRCA1 ATM PAH PMC8799118__F5 Discovered differentially expressed lncRNA AC010973.2 can act as a diagnostic and prognostic biomarker for colon adenocarcinoma BAX EGF DCC BAD TGFA SMAD2 APC SMAD4 AREG MTOR RHO ERG TGFBR1 CTNNB1 POLK CASP3 GRB2 CCND1 PMC8910341__F1 Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits SYK BTK BCL10 BCR CD72 GC CD22 CD19 LYN PMC7893122__F1 Hedgehog signaling pathway and representative inhibitors of SMO, GLI and BRD4 BRD4 SUFU PTCH1 SMO CCND1 GLI3 PMC3178431__F6 p63 signaling in cancer cells RHEB STAT3 TSC2 APC GSK3B PTEN CTNNB1 PMC4107983__F1 Transcriptional programs controlling endocytosis EGFR TFEB HIF1A PMC3695880__F1 The wiring diagram of the UPR model MBIP ATF4 EIF2A PMC3166148__F3 The citric acid cycle pathway (reprinted from KEGG ) SUCLA2 ACO2 SUCLG2 HEL-S-32 PMC5923365__F1 Cellular pathways affected by genes significantly mutated in ALL FLT3 EGFR BRAF PTPN11 PTEN MTOR CTNNB1 ARAF TSC2 CBL ATM SH2B3 MDM2 GRB2 PMC8781990__F4 Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host CS ADA PMC5362592__F1 Different pathways induced by ALS proteins converge on translational repression FUS MAP1B EIF2A RAC1 HEL-S-44 PMC8781990__F5 Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host GIN1 APP PMC3574819__F10 O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation ATR H2AX ATM PMC12203532__F5 A) GNN explainer outputs node and edge importance for each sample CD200R1 DPT UBE3B PMC7918973__F1 Nrf2/ARE signaling pathway KEAP1 GCLM NQO1 GCLC MAF PMC8526709__F3 KEGG enrichments of DEGs in protein-protein interaction network (PPI) NR1i1 JUND CYP24A1 EGR1 SP1 LRP6 MAFB ARHA GATA3 CASR HBEGF FGFR1 GCM2 PDE4D PTH FGF23 PMC7431487__F1 Antiviral signaling pathways induced during viral infection TBK1 MAVS TANK IRF1 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR3 TLR8 TLR7 ISG15 PMC4403607__F12 Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity CDC2 BAX CDK12 MTOR CCND1 CDK4 PMC7145358__F3 Intra- and intercellular modulation of melatonin synthesis GC AANAT ME1 PMC8417798__F9 Obesity Attenuates Ventilator-Induced Lung Injury by Modulating the STAT3–SOCS3 Pathway STAT3 WNK4 SOCS3 PMC6628922__F5 Gestational Binge Alcohol-Induced Alterations in Maternal Uterine Artery Transcriptome AAK1 CRK VASP MME FER PXN THY1 F2 CYBA RAC1 CTNNB1 PMC5686665__F1 Lipogenesis, sphingolipid, and PA synthesis pathways ACLY UGCG CERK FASN KDSR PMC6497434__F1 New mechanistic insights into modifiable risk factors that promote pancreatic cancer STAT3 CXCL12 CXCR4 PMC5495030__F1 Canonical TGFB signaling pathway SMAD2 SMAD4 SKI PMC4649510__F7 Model of tissue homeostasis maintenance after an ER stress ATF4 HEL70 XBP1 RAC1 PMC6405822__F1 BMP signal transduction SMAD1 DKFZp781O1323 SMAD6 SMAD4 PMC7279047__F1 Aryl hydrocarbon receptor (AhR) signaling pathway CYP1A2 AIP AHR AHRR CYP1B1 PMC9496836__F1 Sirtuin 1 in Host Defense during Infection TGFB1 MTOR ATG5 SIRT1 PMC8782557__F1 Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases MLST8 ATM SIRT1 PARP1 IRS1 PMC6168922__F5 Signaling via the ALX/FPR2 receptor FPR1 APP FPR2 PMC7849055__F5 Diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence CD36 GSK3B PTEN IRS1 PMC3934462__F1 Apoptosis signaling and cell death relevant drugs BAX TRADD APAF1 FADD PMC11040941__F6 C6orf15 promotes liver metastasis via WNT/Beta-catenin signalling in colorectal cancer CPT1A LEF1 CTNNB1 PMC2685877__F1 Combined Yeast-derived Beta-Glucan with Anti-tumor Monoclonal Antibody for Cancer Immunotherapy CD40 TH APC PMC5492892__F1 Molecular networks between genes involved in NB development by the data mining IPA software ALK BRCA1 CHEK2 BCL2 MMP20 TERT KRAS PALB2 PMC3753504__F39 Activation of different death receptor signaling pathways depending on the culture conditions of hepatocytes HTRA2 BAX DIABLO FADD PMC2906263__F3 Suppression of IFN-induced Jak-STAT signaling in hepatitis C PRMT1 IFNLR1 IFNAR2 IRF9 USP18 IFNAR1 SOCS3 JAK1 TYK2 PMC6318427__F2 Current model of iron sensing in the liver to regulate hepcidin production BMP6 TFR2 HFE FURIN HFE2 PMC12153880__F1 The cGAS/STING pathway TBK1 CGAS IRF3 PMC5070595__F2 Relevant aspects of complement activation and inflammasome activation with their possible interconnection NLRP3 HEL-S-62p IL1B PMC7574648__F7 Model summarizing the functional relationship between Rab5-Rab11 GTPases and BDNF/TrkB-mediated CREB transcriptional regulation EGR1 ARC MTOR BDNF PMC7377856__F7 Proposed scheme for the possible mechanism of EA pretreatment suppresses CIR-induced autophagy via the SIRT1-FOXO1 signaling pathway FOXO1 SIRT1 PMC6664092__F6 Overview of QTG involved in organoleptic compound production MDH2 SKP2 MAEL PMC7873566__F3 Formation of the signaling-competent IL-1R complex and downstream IL-1 signaling IL1R2 IL1R1 UBC MAP3K7IP1 TAB3 IRAK1 IRAK2 PTGS2 TRAF6 TNF CXCL8 IRAK4 PMC5876464__F1 Signaling pathway of GRP78 ATF4 PMC2676892__F3 Chronic Lymphocytic Leukemia and B and T Cells Differ in Their Response to Cyclic Nucleotide Phosphodiesterase Inhibitors FOSL2 HMGCR NR4A3 CREM SLC2A3 SOCS3 AREG PDE4A PMC9102406__F3 Review of Toxicity Mechanism Studies of Electronic Cigarettes on Respiratory System KEAP1 EGFR AHR NOD1 CYP1A1 HEL-S-44 PMC12094572__F3 Molecular mechanisms of exercise-enhanced brain neuroplasticity by enhancing various peripheral factors NLRP3 APPL1 ADIPOR1 FGF21 PMC9526990__F1 Long non-coding RNAs affecting cell metabolism in cancer HEL-S-133P HK2 PMC12094572__F1 Effects of ADPN on metabolism in peripheral organs and related signaling pathways IL15 ADIPOR1 FOXO1 PMC8264452__F1 Use of Biologic Modifiers as a Bridge to Hematopoietic Cell Transplantation in Primary Immune Regulatory Disorders APC LRBA PMC8215834__F7 Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway STAT3 IL6 SRC TNF PMC3454471__F5 Redox regulation of the Nrf2–ARE pathway BACH1 KEAP1 MAF PMC3541279__F5 Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury MADD TBCB NGF NTRK2 SHH LINGO1 SMO ARHA BDNF TRAF2 FADD PMC6933942__F5 Summary of proposed mechanistic pathway of S1PR1-induced mechano-hypersensitivity S1PR1 NLRP3 IL16 TNF IL1B PMC3541279__F2 Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury TH LIPI GAL BAD CRAT TRADD CRH NFKBIA APP HEL-S-11 BIRC2 TRAF2 PMC2775236__F1 The effect of neuronal activity on the function of the miR379-410 cluster member miR-134 LIMK1 BDNF PUM2 PMC5416999__F11 Signaling mechanisms for PGF2A and AL-8810 stimulation of FP receptor EGF HBEGF EGFR SRC PMC3002356__F6 Proposed model of GS-mediated apoptosis in HNSCC cells BAX BAD FADD PMC7461721__F5 Signaling Pathways Converge on Profilin TF HDAC1 SMAD2 ROCK1 SMAD4 MMP2 ARHA MMP9 SRC VHL PMC8117212__F3 Proprotein Convertases in the Regulation of the Function of Immune Cells in the Oncoimmune Response STAT3 TLR4 IRF3 MYD88 PMC6129509__F10 Pi3k-akt signaling pathway interactions CCNE1 BRCA1 COL4A1 CDK2 LAMC1 CDK4 PMC5511646__F2 Cardiac hypertrophy (a) and cardiac fibrosis (b) signaling pathways GSK3B HDAC5 GATA4 PMC9138861__F7 Targeting TKI-Activated NFKB2-MIF/CXCLs-CXCR2 Signaling Pathways in FLT3 Mutated Acute Myeloid Leukemia Reduced Blast Viability CD44 FLT3 CD74 CXCL5 NFKB2 CXCL1 MIF IL8RB CXCL8 CDK4 PMC3821580__F2 Schematic representation of the functional/physical relationship between Dystrophin-Syntrophins-nNOS pathway and miRNAs involved in such signaling, both in a WT and a DMD context COL1A1 DMD HDAC2 PMC4642996__F7 A proposed scheme for BRCA1 and Gamma-H2AX-dependent DNA repair in neurons under normal conditions and in HD BRCA1 H2AX ATM PMC2840670__F1 K-ras mutation governs the effects of inhibition of epidermal growth factor receptor (EGFR) on the Ras/Raf/Mek signaling pathway EGF TGFA EGFR PMC6291505__F1 The involvement of several TMEMs in tumor growth through the TGFB signaling pathway TF TMEM158 TMEM97 TMEM88 TMEM14A GSK3B CTNNB1 PMC9086835__F7 LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis HEL-S-133P MTOR PMC5501768__F1 Scheme depicting mechanisms of resistance observed to BRAF and MEK1/2 inhibitors in vitro and in vivo AXL EGFR BRAF NRAS ERBB2 PTEN PMC8602198__F2 Contribution of miRNAs in the Pathogenesis of Breast Cancer ATG10 HMGB1 SAG ATG3 ATG12 SNAP29 UVRAG BCL2 SQSTM1 MTOR STX17 ATG5 PMC8602198__F1 Contribution of miRNAs in the Pathogenesis of Breast Cancer STAT3 BAX CASP9 STAT1 BAD TRADD ROCK1 CASP3 PTEN SRC FADD PMC3952073__F4 TAK1 Regulates Hepatic Cell Survival and Carcinogenesis TBR1 BAX SMAD2 SMAD4 YAP1 CTNNB1 PMC5796038__F3 Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis SERPINA3 ORM1 GPR119 NKAP RSPO3 A4GALT TNF PLA2G7 HEL-S-78p LILRA4 PMC3753504__F28 Influence of hepatocyte culture conditions on signaling and phenotype SMAD2 SRC PMC8547927__F3 PARP Inhibition in Prostate Cancer With Homologous Recombination Repair Alterations BRCA1 BRCA2 PARP1 PMC8336336__F6 Diet-derived transmission of MicroRNAs from host plant into honey bee Midgut SIAH1 ROCK2 APC LRP5 SMAD4 LRP6 RYK ARHA BAMBI SOST INVS CBY1 STOM CER1 SKP1 NLK DAAM1 PMC5862799__F3 The metabolic pathways utilized by T cells in nutrient replete versus metabolically challenging environments HIF1A FOXP3 MTOR PMC9427288__F2 Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs CYP2A6 CES2 CDA RRM2 UCK2 DPYS DPYD UPP2 TYMS UMPS TYMP SLC22A7 PMC8903693__F4 Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them? CDC2 BAX FAS CDK2 MDM2 APAF1 CDK4 PMC2787730__F9 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the cytokine and cytokine-receptor interaction pathway IL15 LEP OSM CCL3 CCL15 IL3 CCR2 IL3RA IL2RG CCR3 IL2RA IL15RA IL11RA CSF3 IL6R CSF3R IL-21 CCL23 CSF2RB CCL21 CCR6 CCL7 CCR7 IL2 IL11 IL9 CSF2 CCL16 LEPR LIF IL4 IL7R IL6 CCL14 CCL13 CNTFR CNTF CTF1 IL2RB CCL19 CCL25 IL9R CCR4 CCL4 IL7 CCL20 PMC4074572__F1 Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology CXCL13 NLRP3 CCL3 TLR4 CXCL1 CXCL2 CCL5 MTOR MYD88 PMC7806239__F7 Positive Feedback Loop Between TGFB and Androgen Receptor Supports Triple-negative Breast Cancer Anoikis Resistance SMAD2 SMAD4 PMC5666340__F4 CyaA toxin of B.pertussis inhibits the TRIF-dependent signaling pathways in human monocyte derived dendritic cells (MDDC) STAT1 TIRAP TLR4 IRF3 TRAF6 MYD88 PMC8303609__F4 KIR Receptors as Key Regulators of NK Cells Activity in Health and Disease ZAP70 SYK HLA-G LAT GRB2 PMC7013742__F2 Putative SUR1 molecular signaling pathways beyond cerebral edema in brain injury BAX NOS2 GFAP SP1 PATE1 TLR4 PLG CCL2 TRPC3 PMC1421301__F1 Interferon Regulatory Factor Expression in Human Breast Cancer STAT1 MHC2TA IRF2 TAP1 PMC3420877__F8 Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice EGF EGFR SRC PMC10935305__F9 Graphical illustration of the interaction between the gut microbial SCFA-induced Nrf2 redox signaling pathway and LPS/ROS facilitated systemic inflammatory cytokines NLRP3 GSTA4 COX2 TLR4 NQO1 TRAF6 MYD88 PMC7308735__F3 GPNMB contributes to a vicious circle for chronic obstructive pulmonary disease CSF2 GPNMB TNFSF11 MMP9 MYC PMC4526263__F1 Cellular alterations and molecular mechanisms involved in hepatic cystogenesis SEC63 IGF1 CFTR HIF1A MTOR PMC1877091__F15 PDCD10/MST4 signaling pathway and CCM protein function PDCD10 PMC2856329__F9 Brx-mediated osmotic stress-activated signaling system and its implications for the immune response CDC42 LTB NFAT5 RAC1 IL1B PMC3735826__F5 miRNA-548c: a specific signature in circulating PBMCs from dilated cardiomyopathy patients NR3C2 BIRC5 PRKCE SMAD2 RS1 PTEN VEGFA EGLN3 HDAC2 FOS VHL PMC7387202__F1 IGF system and its components IGF2R IGFBP5 IGFBP1 IGFBP2 IGF1R IGFBP6 PMC7937875__F7 Canonical pathway analysis HMFT1766 HSPG2 TIMP1 SELL SGK1 SERPINA3 CFH B2M CS IL6 HEL-S-78p SPP1 PPBP C2 A2M FGA VCAM1 SAA4 ADAMTS2 S100A9 XLKD1 PMC5384577__F2 Possible roles of Mgs1 and WRNIP1 in DNA transaction WRNIP1 RAD18 RAD52 ATMIN RAD51 MRE11A PCNA BRCA2 ATM POLN FBXO18 PMC8209977__F1 Homologous recombination, cancer and the ‘RAD51 paradox’ BRIP1 RAD51D STK11 RAD51 BRCA2 PTEN XRCC3 BARD1 RAD51C BRCA1 NF1 CHEK2 ATM PALB2 IMPACT PMC7028932__F2 Oncogenic pathways activated in T-ALL, the downstream signalling network of interleukin-7 (IL-7), NOTCH1, and polycomb repressor complex 2 (PRC2), and potential therapeutic targets SUZ12 EED FBXW7 EZH2 PTEN MTOR NOTCH1 PMC8990307__F2 Microglia and Neuroinflammation: Crucial Pathological Mechanisms in Traumatic Brain Injury-Induced Neurodegeneration TREM2 GSDMD NLRP3 TLR4 IRF3 PMC4177363__F5 Transcriptional response to dietary restriction in Drosophila melanogaster RAN UTP6 COMP UTP4 IMP3 NMD3 DKC1 IMP4 NHP2 PWP2 NOB1 UTP18 NOP10 LSG1 POLI EMG1 NHP2L1 DRG1 NOP58 PMC7653638__F5 FGFR1 and KLB effect on endocrine vs canonical FGF signaling FGF21 FGFR1 FGF2 PMC2566006__F2A A Defect in Menadione Biosynthesis Induces Global Changes in Gene Expression in Staphylococcus aureus HEL107 SDHA SDHB CDA PDC GLA SUCO SDHC ADA GAPT PMC6698547__F2 LMP-1 rescues Smads from Smurf1-mediated proteosomal degradation SMAD1 SMURF1 DKFZp781O1323 PMC5955428__F2 Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk EGF MOS GRB2 BDNF PMC3464734__F2 Pre-treatment expression of TLR, RIG-I and IFN-beta pathway genes compared between the two patient groups CSA2 TIRAP MAVS IKBKE PIK3R1 IFIH1 TLR9 IRAK1 ATF2 SOCS3 TRAF3 MAPK8 TRAF6 IRAK4 MYD88 MAPK14 ISG20 ZBP1 TLR4 TLR7 ISG15 OAS1 EIF2AK2 JUN STAT2 IRF9 IRF3 IRF7 RSAD2 CXCL10 NFKBIA IFNB1 TNFSF10 PMC7486775__F1 Candidate pathways supporting phosphoglycolate salvage in C MAEA PDHA1 C2 PDHA2 PMC3366012__F2 TNIP1-mediated signaling pathways CASP8 TRADD EGFR CASP3 TRAF2 FADD PMC3217196__F1 MicroRNAs in Mutagenesis, Genomic Instability and DNA Repair CDC42 CCNG1 ATR H2AX ATM PMC6202849__F2 Schema of deriving corneal cell phenotype from iPSCs PAX3 ABCB5 SOX9 BMP4 SOX2 CSK TFAP2A NODAL SOX10 ABCG2 PAX6 PMC8508869__F1 Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway STAT3 MTOR SRC PMC5323160__F10 Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis CDC42 FYN SHB VEGFA SRC PMC7697192__F2 Kin regulates macrophage polarization through MAPK, NFKB, and STAT6 signaling pathways IL10 ARG1 IL6 KIN IL1B PMC4384220__F1 PI3K-Akt-mTOR signaling pathway RHEB TSC2 BAD TSC1 PTEN MDM2 PMC8645962__F1 Acetylation in Tumor Immune Evasion Regulation SIRT7 SIRT4 SIRT5 SIRT2 HDAC3 HDAC1 SIRT3 IFNG HDAC10 HDAC8 HDAC5 HDAC7 HDAC11 FOXP3 JAK1 HDAC2 SIRT1 SIRT6 HDAC6 PMC3808414__F8 Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy TMEPAI PDPK1 PMC8289466__F10 Prognostic Value and Significant Pathway Exploration Associated with TOP2A Involved in Papillary Thyroid Cancer ENG KEL APP HEL-S-11 PMC11019597__F3 Heterologous fibrin biopolymer as an emerging approach to peripheral nerve repair: a scoping review MUSK LRP4 MMP3 PMC5323150__F12 SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride GADD45A SIRT1 PMC3745317__F1 Eicosanoid biosynthetic pathway and its activation by RTK/GFR → ERK1/2 signaling LOX COX1 COX2 C2 EGFR PMC7352599__F2 SRC constitutive activation modulates inflammation and metabolism concurring to tumor microenvironment sustainment in GBM STAT3 SRC PMC7059830__F1 Glycolytic-lipogenic pathway in TH17 cells FAS HMGCR HEL-S-133P HK2 MTOR MYC PMC9241288__F2 Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update AQP4 CD44 GDNF COX2 MSC VEGFA BDNF PMC2991775__F1 Pathways leading to the type I interferon production HMGB1 TBK1 IL10 TIRAP MAVS TAB3 TANK TLR9 CD14 RNASEL AIM2 IRF3 IRF7 TRAF3 RAC1 SPP1 BTK TLR3 TLR4 TLR8 TLR7 EIF2A FADD PMC3186862__F1 BAD pathway in genes associated with induced cisplatin-resistance HRAS CDC2 BAD IGF1 MAPK13 PDPK1 EGFR GRB2 IRS1 PMC5116261__F1 PI3K signaling: a molecular pathway associated with acute hypophagic response during inflammatory challenges RHEB STAT3 TSC2 TSC1 INSR LEPR POMC PTEN MTOR PMC4091817__F2 The oxidative stress regulatory pathway in erythrocytes TXN HEL-S-2a GPX1 HEL-75 HEL-S-44 PMC5945837__F8 Galactose metabolism pathway in Streptococcus pneumoniae D39 GAL TBP PMC5832136__F6 Anti-liver cancer mechanism of TF TF BAX BAD PTEN PMC7608107__F7 A proposed working model wherein miR-210 positively regulates microglia-mediated neuroinflammation via activating the NFKB signaling pathway by targeting SIRT1 and blocking p65 deacetylation IL6 SIRT1 IL1B PMC10934612__F3 Gene regulation in fatty acid metabolism pathways by GFIPO compared to WEGG LPA TG GPAT4 MTTP CIDEA FASN LIPE APOB ACACA ADA PMC3406244__F3 Thyroid Hormone Receptors and Cancer SP1 ELL MMP2 MMP9 MTOR SRC CTNNB1 CP PMC11010636__F2 Exploring the regulatory mechanism of intestinal flora based on PD-1 receptor/ligand targeted cancer immunotherapy CXCR3 CGAS NOD2 PMC7551725__F2 Tryptophan (Trp) metabolism and AhR pathway in health and disease STAT3 IDO1 AHR PMC3441782__F6 Molecular network of downregulated genes in U373MG cells following exposure to ET-770, the compound 1a JUN BAD POTEA BTC SHE PMC3441782__F7 Molecular network of upregulated genes in U373MG cells following exposure to ET-770 derivative, the compound 3 RAD21 CDC20 PCNA E2F4 MAL MIB2 CDK2 SKP2 PMC3387019__F7 Cardiac Kallikrein-Kinin System Is Upregulated in Chronic Volume Overload and Mediates an Inflammatory Induced Collagen Loss MMP3 ACE2 PMC6479968__F1 Protein C activation by the thrombin-thrombomodulin complex and the cytoprotective function of Activated Protein C (APC) in ischemic heart disease and heart failure APC PC RAC1 PMC9244704__F10 Integrated Metabolomics and Transcriptome Analyses Unveil Pathways Involved in Sugar Content and Rind Color of Two Sugarcane Varieties GNS TREH GYG1 PMC4377327__F5 Regulation of microRNA function in somatic stem cell proliferation and differentiation VAV3 MSI2 SKP2 PMC8301030__F1 Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans PTS HIST1H1E PMC4377327__F6 Regulation of microRNA function in somatic stem cell proliferation and differentiation SOX6 REST SOX9 PTBP1 PDGFRA CTDSP2 FOXJ3 HES5 PMC5082389__F5 IL-17 F signaling pathway is epigenetically altered in malignant COPD and non-malignant COPD lung airway epithelial cells IL17RC CXCL1 LCN2 PMC8301030__F9 Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans EGF BAD WNT3A GSK3B CTNNB1 PMC8497904__F6 Lgr4 Regulates Oviductal Epithelial Secretion Through the WNT Signaling Pathway CYP11A1 HSD3B1 NR5A2 CTNNB1 PMC3185611__F1 PRRs involved in detecting flaviviruses TLR3 IRF3 TRAF3 TRAF6 IFNA1 PMC9338538__F3 Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions VWF HEL-S-62p HEL-S-11 PMC4648419__F5 Enriched pathway of Integrin (A) and migration (B) HEL-S-22 HEL113 CANX HEL-S-269 FLNA HEL-S-99n MYLK EZR MYH9 PAH TLN1 HEL2 EMILIN1 ACTN1 PDIA4 MYL6 ITGA7 FLNB APOE HEL-S-89n PARP1 HEL114 HEL-S-125m ITGA1 ACTN4 MVP PLEC YWHAZ PMC9083130__F7 Integrin A4 up-regulation activates the hedgehog pathway to promote arsenic and benzopyrene co-exposure-induced cancer stem cell-like property and tumorigenesis ITGA4 SUFU PMC2443667__F1 Connections between the SAM cycle, transsulfuration pathway, and glutathione production GCLM GCLC CTH HEL-S-61p MTR HEL-S-64p PMC5167048__F3 Age‐associated defects interfering with function and survival of activated T cells STAT1 EGR1 CD69 DUSP4 PMC7017935__F12 Antral follicle steroidogenesis STAR HSD3B1 HSD17B1 PMC8535158__F4 NUAK Kinases: Brain–Ovary Axis TF HDAC1 NUAK1 IGF1 SMAD2 MMP2 MMP9 PMC2785127__F5 Putative targets of common changes in gene expression with single and repeated IMO stress TH PARG FOS PMC4447104__F1 Bacteria, the ER and the Unfolded Protein Response: Friends or Foes? ATF4 EIF2A XBP1 PMC5968105__F1 Senescence-associated secretory phenotype (SASP) is regulated by an interactive network of pathways that dictate its functional outcome EBP CXCL1 ATM CXCL2 MTOR NOTCH1 PMC5634503__F7 Proposed mechanism TF RPE RAB1A PMC11904505__F3 Endometrial carcinoma (EC) cells strategically employ immune checkpoint pathways, with a notable focus on the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis KRAS PMC4245458__F2 Regulatory cross-talk between the estrogen receptor alpha and MTA family members MTA2 MTA3 GRB2 PMC8773035__F1 Exosomal microRNA Differential Expression in Plasma of Young Adults with Chronic Mild Traumatic Brain Injury and Healthy Control RPS15 ACSL6 EPHB6 VASH1 PTEN HOXA11 VEGFA TNF PMC9408827__F3 Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities COMP ALPL COL9A1 COL10A1 RUNX2 COL2A1 PMC12174428__F1 IFN signaling in beta-cells and autoreactive T-cells (inset) via JAK/STAT pathway in T1D IFNGR1 IFNLR1 STAT2 IRF9 JAK3 CXCL10 XBP1 ATF3 STAT1 IFNGR2 HLA-E JAK1 TYK2 PMC8313993__F1 Metabolic pathway map illustrating high-value bioactive ingredients for food, agricultural feed materials, human health, and well-being products, provided by Corynebacterium glutamicum cell factories IPP MIF PROC STS PMC3814639__F2 Schematic model of the Nrf2–Keap1 signaling pathway RBX1 KEAP1 GCLM MAF PMC3814639__F3 Cross-talk between Nrf2 and other proteins RBX1 KEAP1 MAF DPP3 PMC3262331__F2 Schematic signaling pathway mediated by the L-CBM complex in T and B lymphocytes.Notes: The L-CBM complex acts in the canonical NFKB (p65/p50, cRel/p50) activation pathway mediated by IKKB downstream of TCRs and BCRs BCL10 BCR TLR4 RELB TRAF6 MYD88 PMC3262331__F3 Schematic signaling pathway mediated by the L-CBM complex in NK cells.Notes: The L-CBM complex acts in the canonical NFKB activation pathway through activating NK cell receptors (NKR) such as Ly49H, Ly49D, NK1.1, NKG2D, FcGRIII, etc BCL10 VAV1 RAC1 MYD88 PMC4393718__F2 EphA/ephrinA bidirectional signalling CDC42 STAT3 CRK HEL-S-28 RRAS RHO SRC PMC7237878__F1 Possible associations of the renin-angiotensin system with SARS-CoV-2 infection and lung injury caused by SARS-CoV-2 TMPRSS2 ADAM17 ACE2 PMC6225117__F1 Molecular mechanisms of (-)-epigallocatechingallate (EGCG) suppressing the proliferation of cervical cancer cells IGF1 EGFR CDK2 MTOR PMC9179436__F1 Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment STAT2 JAK1 TYK2 PMC9179436__F2 Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment STAT3 WNT3A AHR FOXP3 PMC3536343__F1 MTORC1 signaling to the translational machinery RHEB MAF1 RPS6 EEF2K TSC2 EIF4B TSC1 EEF2 PTEN DEPTOR PMC8745410__F1 Development and Use of Akt Inhibitors in Prostate Cancer TSC2 TSC1 PTEN MTOR PMC3536343__F4 MAPK signaling to the translational machinery RHEB RPS6 EEF2K TSC2 EIF4B TSC1 EEF2 DEPTOR EIF4E PMC4429241__F2 Signal transduction pathways activated by DNA to stimulate type I IFN expression BAX TBK1 CGAS MAVS ZDHHC1 TLR9 IRAK1 IRF3 IRF7 TRAF6 IRAK4 MYD88 TRIM25 TRAF5 AMFR TRAF2 PMC9028356__F1 Resistance to Photodynamic Therapy (PDT) in Vulvar Cancer SLC25A38 HMBS CPOX ABCB6 ABCG2 FECH ABCB10 UROD UROS PMC11061161__F3 Amino acid metabolism modulates T cell survival and lineage commitment TH MTOR PMC7766764__F4 Regulatory network for fungal dimorphism in U HEL-S-8a ROS1 CLP1 CIB2 CDK5 PRF1 MED1 RAC1 PMC9473615__F7 SAMD9 effect to DNA sensing pathway and proinflammatory responses CGAS SAMD9 IRF3 PMC11061161__F1 T cell activation and subset differentiation and function by lipid metabolism STAT3 FAS SULT2B1 CD36 AQP9 CPT1A PMC10882095__F5 Immune molecule interaction network in the blood and heart tissues of chronic Chagas disease (CCC) patients CXCL9 IFNG CCL5 CXCL10 CCL2 PMC2575513__F2 Diversification of the innate immune arsenal in amphioxus NAIP TIRAP TLR4 NOD2 NOD1 TNF MYD88 PMC4106758__F6 Visualized Gene Network Reveals the Novel Target Transcripts Sox2 and Pax6 of Neuronal Development in Trans-Placental Exposure to Bisphenol A PROX1 IGF1 SOX2 SHH PAK6 VEGFA NOTCH1 FGF2 GLI3 PMC4429241__F4 Signal transduction pathways activated by DNA to stimulate activation of inflammasomes and the NFKB pathway RAD50 MRE11A IL18 AIM2 IL1B CARD9 PMC7662426__F3 Molecular signaling pathway of PA28G in cancer PTTG1 MDM2 SIRT1 PMC4429241__F5 Endogenous and microbial mechanisms to downmodulate and evade DNA-driven innate immune responses TBK1 CGAS MAVS TRIM25 ATG9A ULK1 NLRC3 AIM2 IFI16 TREX1 DNASE2 PMC6608593__F4 PANTHER Pathway: an ontology-based pathway database coupled with data analysis tools ADRBK1 RAF1 PMC5570578__F7 Illustration describing the role of HPV E6/E7 oncogenes and HPV E6/E7 siRNA with cisplatin (CDDP) plus paclitaxel (PTX) therapy on HPV-infected cervical cancer cell fates ATR CDK2 ATM PMC11063389__F2 Therapeutic targets and inhibitors targeting JAK2/STAT3 signaling pathway for TNBC treatment GAA STAT3 PMC5369176__F1 Physiological functions of PD-related Rabs RAB10 RAB32 RAB13 RAB35 PMC5361605__F4 GIST and apoptosis signaling BAX CASP9 BIRC5 BAD CASP6 CYCS CASP3 BCL2 APAF1 DIABLO PMC7092730__F1 Three adipogenic transdifferentiation pathways EBF2 IGF1 EBP MSX1 PRDM16 BMP2 MYF5 EHMT1 PAX7 PMC3321615__F1 Canonical and noncanonical pathways of NFKB activation CD40 TLR4 RELB CD14 PMC9264937__F3 p53 Isoforms as Cancer Biomarkers and Therapeutic Targets BAX RAD51 PMC10967338__F2 EGFR wild type and EGFRvIII mutated comparison EGF TGFA EGFR BTC PMC7936186__F6 Schematic representation summarizing the integrated effects of PFA-enriched diets on intermediary metabolism in the broilers LIPC RPS6KB1 MTOR PFAS PMC10485805__F1 Intestinal flora regulates tumor microenvironment components STAT3 TLR4 CTSK TNF PMC10299676__F1 Mechanisms for activation of the JAK-STAT signaling pathway JAK3 JAK1 TYK2 PMC10967338__F7 TGFB canonical intracellular pathways and single-domain vNAR T1 coupled to TGFB1 SMAD2 SMAD4 PMC6114229__F1 Schematic presentation of MAPK/Ras signaling pathway EGF EGFR GRB2 PMC10967338__F3 Therapeutic tyrosine kinase inhibitors and anti-EGFR monoclonal antibodies in glioblastoma anti-EGFR mAbs bind the EGFR extracellular domain, preventing EGFR dimerization and subsequent activation RHEB STAT3 EGF TSC2 TGFA TSC1 EGFR BTC PTEN GRB2 PMC10967338__F4 IL13RA1/IL4RA JAK-STAT6 pathway, IL13RA2, and single-domain vNAR coupled to IL13RA2 IL13RA1 IL13RA2 PMC10967338__F5 Allosteric inhibition of Aurora-A kinase by the vNAR-D01 intrabody TBX2 STAT3 AURKA BAX EGF RAD51 EGFR BRCA2 GSK3B CTNNB1 BRCA1 MDM2 HCTP4 CLDN1 PMC7804955__F7 circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity IFNE NDUFB2 MAVS IRF7 PMC5677022__F3 10-miRNA-score predicts defects in the HR pathway in ovarian cancer ATR EMSY RAD51 BRCA2 BRAF PTEN PLK1 RB1 FANCD2 CDKN2A FOXM1 BIRC5 CCNE1 BRCA1 CCND2 NF1 AURKB CHEK2 ATM CCNB1 CDC25B CCND1 PMC8036376__F1 Metabolic pathway of clopidogrel and its target receptors CYP1A2 CYP2B6 CES1 CYP2C19 CYP2C9 ABCB1 PMC9614394__F11 Schematic mechanisms by which Wnt agonist 1 (Wnta1) regulates atrial atrial natriuretic peptide (ANP) secretion and mechanical dynamics TCF3 MAP3K7IP1 TCF4 ATF2 LEF1 PMC8594875__F8 S-nitrosoglutathione reductase (GSNOR) deficiency accelerates cardiomyocyte differentiation of induced pluripotent stem cells GSK3B NKX2-5 CTNNB1 PMC7686704__F2 Wnt–PCP signaling pathway in mammals CDC42 MUSK INVS INTU CELSR1 PTK7 RYK ARHA RAC1 PMC7686704__F3 Wnt–Ca2+signaling pathway in mammals CDC42 STIM2 INSR STIM1 RYK ATF2 NLK CTNNB1 PMC11141153__F6 AMPK signaling pathway depicted using KEGG in tissue lysate fractionThe levels of upregulation of the proteins observed in AMPK pathway are as follows: CAB39/MO25 log2 0 FAS CAB39 CD36 MTOR PDK2 INS RHEB TSC2 IGF1 INSR F2 PPP2R1B CFTR PMC7686704__F1 Canonical Wnt signaling pathway in mammals SIAH1 APC LRP5 IGFBP4 LRP6 RAC1 CTNNB1 BCL9 SOST RNF43 TNKS NOTUM ZNRF3 GPR49 PMC7686704__F8 Wnt signaling in breast cancer drug resistance CYP1A2 CYP2B6 CYP2C19 CYP2C9 ABCG2 CYP3A4 ABCB1 CTNNB1 PMC8955684__F2 Angiopoietin-Like Protein 4 and Insulin-Like Growth Factor-1 Expression in Invasive Breast Carcinoma in Young Women STAT3 BAD IGF1 BCL2 IGF1R MTOR IMPACT PMC5925582__F7 Illustration of p204 function in LPS/TLR4 signaling pathway TBK1 TIRAP CD14 TANK IRAK1 IRF3 TRAF6 IRAK4 MYD88 PMC5159240__F1 Oncogenic and tumor-suppressive mouse models for breast cancer engaging HER2/neu JUN BAD SP1 DMP1 HSF1 PTEN MDM2 GRB2 MYC CCND1 FOS PMC12026008__F2 Natural Products in the Treatment of Neuroinflammation at Microglia: Recent Trend and Features KEAP1 TLR4 MTOR PMC4208300__F3 Simplified outline of the MyD88-signaling pathway by which TLR agonists induce the production of inflammatory mediators CRTC3 TAB3 IRAK2 TRAF6 TNF IRAK4 MYD88 PMC5949249__F1 To Eat or Not to Eat – The Metabolic Flavor of Ferroptosis TFRC GPX4 GC SLC38A1 GLS2 ADA PMC5809773__F2 Biosynthesis of galactolipids in the chloroplast envelope membranes in Arabidopsis GAL HEL-S-11 PMC3175721__F6 Models for context-dependent ICL repair during replication SIX4 FAN1 PMC3874238__F2 Insulin is the major hormone controlling critical energy functions such as glucose and lipid metabolism BAD ASIP PTEN SOCS3 TNF IRS1 EIF4E RHEB CRK TSC2 PDE3B TSC1 GRB10 FYN GRB2 EHD1 PMC4114929__F3 Importance of RhoGTPases in formation, characteristics, and functions of invadosomes CDC42 VASP ARHA PMC11928533__F3 Diverse biological functions of the CRIP family BAX VEGFC FAS CXCL5 CXCL1 APC BBOX1 MTOR CCL5 CRIP2 CRIP1 CTNNB1 STUB1 ATOX1 IFNG CREB1 CCND1 PMC8904073__F7 Dickkopf-3 and Beta-catenin play opposite roles in the Wnt/Beta-catenin pathway during the abnormal subchondral bone formation of human knee osteoarthritis DKK3 APC GSK3B LRP5 LRP6 CTNNB1 PMC4870363__F1 Schematic overview of TLR signaling pathway in neutrophilic and eosinophilic asthma TLR3 TLR4 TLR8 TLR7 IL1B MYD88 PMC8227265__F1 Enhancing Sesquiterpenoid Production from Methane via Synergy of the Methylerythritol Phosphate Pathway and a Short-Cut Route to 1-Deoxy-D-xylulose 5-Phosphate in Methanotrophic Bacteria IPP MAL SCO2 CIT PMC4439431__F1 Metabolism of a resting uninfected cell ACLY HMGCR FASN ACACA PMC6763723__F1 VLC-SFA and VLC-PUFA elongation pathways ELOVL4 ELOVL3 ELOVL2 ELOVL1 ELOVL5 ELOVL6 PMC4439431__F2 Metabolism of a cell infected by HCMV ACLY HMGCR COX2 FASN PMC4439431__F3 Metabolism of a macrophage activated by immune signals ACLY HMGCR COX2 FASN ACACA PMC7982634__F3 Natural extracts exert inhibitory effects on PI3 K/Akt signaling pathway RPS6 CASP9 BAD GSK3B PTEN MDM2 GATA4 PMC7982634__F4 Natural extracts block NF‐KB signaling pathway ECSIT TRADD TNF TRAF2 MYD88 PMC7982634__F1 Natural extracts can induce apoptosis through ERS pathway and mitochondrial pathway BAX CASP12 ATF4 PMC7340679__F1 Anticancer activity of mistletoe MCL1 CDK2 BCL2 CCND1 CDK4 PMC11728246__F2 TRAPPC4 and TRAPPC9 in cell signaling TRAPPC4 TRAPPC9 RELB PMC11118191__F2 Overview of USP36-mediated signaling pathways LATS1 FXR1 LATS2 ANKRD1 USP36 CEP63 HK2 MDM2 PARP1 PMC7470069__F5 Mercury-sulfhydryl-dependent effects on apoptosis regulation KEAP1 BCL2 PTEN PMC2713245__F1 Signal transduction through activin receptors GDF11 SMAD2 SMAD6 SMAD4 CTNNB1 PMC8393314__F1 Glycosylation in Melanoma Progression TH MCAM GAL FUT1 FUT4 FUT8 AXL FUT2 EGFR ST6GAL1 PLG TG ST6GALNAC2 F2 GCNT2 ST3GAL5 GCNT3 ST3GAL3 PMC7340679__F7 Probable mechanism of antiobesity activity of mistletoe LPL FAS PMC7396059__F3 NKG2D signaling pathways CRKL VAV1 GRB2 RAC1 PMC6533528__F7 Schematic model of IL‐1B‐ and Fn‐fs‐mediated ADAMTS‐12 and ‐7 stimulation by Runx2 and Wnt/B‐catenin signalling modulation in OA‐SF COMP DKK1 APC ADAMTS12 WNT7B RUNX2 IL1B CTNNB1 PMC7396059__F2 Signaling pathways by NCRs SYK VAV3 LAT VAV2 VAV1 RAC1 PMC6769516__F5 Pathway of the investigated genes involved in apoptosis BAX CASP9 STAT1 BAD FAS CASP8 CASP3 SOCS2 PTEN TNF FADD PMC7940844__F1 Toll-like receptor 9 (TLR9) signaling pathway(s) upon CpG oligodeoxynucleotides (CpG-ODN) stimulation: CpG-ODN is internalized through endosomes where it interacts with the endosomic domain of TLR9 TLR4 TLR9 IRF3 IRF7 IL1B PMC5431817__F4 Summary of the main effects of diabetes and NRG1 treatment in gastrocnemius muscle TFAM ERBB4 CD36 NRF1 PMC2172299__F8 A hypothetical model showing the roles of Fak and paxillin in motile HeLa cells CDH2 CRK RAC1 PMC8002185__F3 Serine/glycine biosynthesis pathway activation in tumor treatment resistance PHGDH EGFR SHMT1 BRAF PSAT1 ATF4 MYC KRAS HEL-S-51e PSPH PMC8664605__F6 Integrative Analysis of DNA Methylation and Gene Expression Profiling Data Reveals Candidate Methylation-Regulated Genes in Hepatoblastoma DBF4 BAX ATR FAS PCNA AIFM2 PERP SMAD4 CYC1 PTEN MTOR MYC TSC2 CDC45 CASP3 CDK2 ATM MDM2 CAP1 CD6 PMC5704042__F2 Structure of SCF/c-KIT proteins and downstream signalling pathways CCND3 BAD CDK2 LYN GRB2 MTOR SRC PMC8002185__F1 Serine/glycine biosynthesis pathway activation in cancer PHGDH SHMT1 PSAT1 HEL-S-51e PSPH PMC4936987__F4 Pathway diagram of the genes in the tricarboxylic acid cycle HEL60 DLAT FH ACO2 OGDH DLD PMC9332011__F1 Hsp90 and Associated Co-Chaperones of the Malaria Parasite GRPR CDC37 PMC8002185__F4 Linking radiotherapy resistance and serine/glycine metabolism in the tumor and associated tumor microenvironment PHGDH PSAT1 HEL-S-51e PSPH IL1B PMC4651103__F1 Working figure of the angiogenesis pathway genes NR1i1 EGFR FLT1 KDR EGR2 TNF IRS1 IL1B TGFBR1 PMC4936987__F2 Pathway diagram of the glycolysis pathway DLAT ALDOB HEL-S-133P HK2 PC DLD HEL-S-32 ENO1 MDH2 MPC2 PFKM PKLR PMC8940980__F1 SARS-CoV-2 Infection: Host Response, Immunity, and Therapeutic Targets TMPRSS2 NLRP3 IL6 ACE2 MYD88 PMC8818156__F8 CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle CDC2 CENPF BAX CCNB1 PMC12249078__F3 Molecular mechanisms lead to uterine fibrosis TF SMAD2 SMAD4 MTOR CTNNB1 PMC7457002__F5 ATF3 plays a vital role in breast cancer ATF3 GOLPH3 PMC3992244__F2 Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer TSC2 RICTOR AAMP TSC1 PTEN MTOR SIRT1 PMC3992244__F3 Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer TSC2 TSC1 PTEN PMC7029724__F4 Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies EGF BAD PAF1 PDPK1 EGFR APC PTEN MDM2 TNF PMC8856111__F1 CounterAKTing HIV: Toward a “Block and Clear” Strategy? EZH2 TSG101 PTEN FOXP3 MTOR CXCR4 PMC6602147__F10 Proposed schematic mechanism of EBV-associated gastric carcinogenesis via the activation of the PI3K/AKT/mTOR pathway, and its blockade by CMG002 ELL PTEN MTOR PMC6106977__F1 MiR-30a significantly inhibits cell proliferation SEC23A UBE3C TFDP1 PRDM1 DTL EZH2 PTEN RUNX2 RPA1 CTNNB1 ATF3 MTDH EYA2 HEL-S-26 CCNB1 SOX4 PMC9703992__F6 Cub pathway ADAM17 EGFR RELA RELB RRAS GRB2 FURIN PMC6106977__F2 MiR-30a significantly promotes cell apoptosis by regulating several relevant effectors MTDH EZH2 PTEN RPA1 PMC5116300__F2 Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease LTB LTA IL4 PMC8323701__F1 Dehydroepiandrosterone sulfate as a scavenging antioxidant: the evidence from Caenorhabditis elegans’ nervous system under hypoxia PMC8071069__F5 FoxO signaling pathway and Glycolysis/Gluconeogenesis pathway IGF1 RBL2 GADD45B PTEN GCK PCK1 PMC2834467__F2 Map showing relationship between genes positively correlated with plasma estradiol superimposed on Ingenuity map MAPK1 ANGPTL4 CELSR2 PMC9331192__F2 Chicken Prolactin, Growth Hormone and Their Receptors in the Immune System IGF1 GHR PMC6080611__F2 Molecular regulation in autophagy ATG16L1 MTOR PMC8139665__F9 TLR3 Activation by Zika Virus Stimulates Inflammatory Cytokine Production Which Dampens the Antiviral Response Induced by RIG-I-Like Receptors STAT3 STAT1 TLR3 IRF3 SOCS3 PMC3814227__F2 Autophagy: regulation RHEB SIRT1 IRS1 PMC8799091__F5 Identification of significant genes in non-small cell lung cancer by bioinformatics analyses SYK MYB BAD BCR FRK MCL1 CYC1 CD19 PTEN RHO PMC9033806__F8 Schematic model illustrates the potential mechanisms by which GXYLT1 and GXYLT1S212* promote the metastasis of CRC EGFR GXYLT1 GXYLT2 HES1 PMC3425953__F1 Activity of Wnt canonical signaling pathway in the normal and tumor cells CRP APC GSK3B LRP5 LRP6 CTNNB1 PMC3425953__F2 The activity of the EGFR/KRAS signaling pathway in normal and tumor cells EGFR BRAF KRAS PMC3425953__F3 The activity of PI3K signaling pathway in normal and tumor cells EGFR PTEN MTOR PMC12170841__F1 Action of sEVs in promoting SC regeneration after SCI: (1) The sEVs alleviate symptoms by modulating the neuroinflammatory response to SCI CNTF CD81 NGF IL10 GDNF CD9 IL4 TSG101 FLOT1 BDNF CD63 PMC11599795__F2 In bladder cancer, YAP1 activity is regulated by YAP1 gene expression, post-transcriptional mRNA modifications, and the activity of the Hippo signaling pathway LATS1 LATS2 YAP1 PMC11599795__F1 Hippo signaling pathway is a key regulator of cellular and systemic metabolism, maintaining organ size and tissue homeostasis by controlling cell proliferation, survival and regeneration LATS1 LATS2 YAP1 PMC8732359__F1 LncRNA Expression Profiles in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Emerging Biomarkers and Therapeutic Targets LTB ROCK2 NOD2 OASL OAS3 SDC1 MTOR YPEL4 OAS2 PMC9695301__F3 Recent Progress in Research on Mechanisms of Action of Natural Products against Alzheimer’s Disease: Dietary Plant Polyphenols TLR4 CCR2 IL1B PMC3671665__F1 Targeting the Sonic hedgehog signaling pathway by compounds and derivatives from natural products PTCH1 SHH SMO PMC10671441__F8 S-Adenosylhomocysteine Hydrolase Downregulation on Wnt Signaling Pathway in SW480 Cells TH FAS HGF BCL2 POLI MYC CSF3 APOF PMC10671441__F9 Human Embryonic Stem Cell Pluripotency Signaling ESRRB DVL1 FGF7A REST LIF TERT NODAL TBX3 MYC DPPA4 FGF2 PMC5100803__F1 Genes associated with the NRF2-mediated oxidative stress response pathway that were differentially regulated in aldosterone-producing adenoma (APA) vs zona glomerulosa (ZG) and ZG vs zona fasciculata (ZF) GSTM4 GSTA3 AOX1 SCARB1 GSTA4 KEAP1 JUNB PRKCA FOS PRKCH PMC10671441__F4 IPA Core analysis of the Epithelial Adherens Junctions Signaling in SW480 AHCY deficient cells with increased expression of LEF1 protein EGF STK11 HGF EGFR IQGAP1 PTEN IGF1R FYN SNAI1 FGFR1 WAS NF2 ARHGAP35 CDH2 SNAI2 ECT2 ARHA YAP1 HEL114 CRK ACTR2 FARP2 NANOS1 ARHGEF17 TIAM1 ZBTB33 FER AFDN NAV2 WASF1 BAIAP2 PMC10671441__F2 Wnt Signaling pathway JUN MAP4K1 APC NR1C2 TCF4 APC2 MYC AXIN2 SFRP1 CTNNB1 CD44 CDKN2A MAP3K7IP1 BTRC DKK1 AXIN1 RUVBL2 MAP3K7 NLK MDM2 NR5A2 HNF1A CCND1 WIF1 PMC6917725__F10 Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases TRADD FADD PMC8914339__F1 Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer HMOX1 STEAP3 KEAP1 HEL-S-102 PMC8914339__F2 Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer GLUD1 LOX GPX4 LPCAT3 FACL4 PMC10341343__F2 Glucose metabolism in cancer cells PGAM1 PFKFB4 HEL-S-133P PHGDH HEL-S-68p F2 HEL-S-162eP PDC LDHB PMC9101486__F6 High-Fat Diet Induces Low-Grade Cochlear Inflammation in CD-1 Mice TAB3 IL6 VCAM1 TRAF6 TRAF2 MYD88 PMC6652202__F4 Protein-protein interaction network TARBP2 PTEN PS1TP5BP1 PMC8628183__F1 ER signaling mechanisms TF GPER SRC PMC5501721__F1 Extracellular nutrients are required to maintain oncogenic signaling in brain cancer – a critical role for mTORC2 TF PIK3CA PTEN PMC8981655__F3 m6A binding protein YTHDF2 in cancer KLF4 PER1 GSK3B SOCS2 PTEN MTOR VEGFA TNF MYC CTNNB1 NKX3-1 AXIN1 YTHDF2 UBXN1 BMF PRSS23 MOB3B HIVEP2 SETD7 LHPP PMC8981655__F4 m6A binding protein YTHDF2 in cancer AGO2 FOXC2 EGFR YTHDF2 SOX10 CXCR4 PMC9597993__F2 Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy IL20RB STAT3 IL19 ICOS PLA2R1 IL24 C2 APC SOX2 IL20RA JAK1 PMC7722523__F1 Molecular Pathway Activation Downstream of BCR-ABL1 BCR CRKL SMO GRB2 MTOR GAB2 CTNNB1 PMC4007780__F1 CADBIOM model for the canonical TGFB pathway TG SMURF2 PMC6312894__F1 From Bench to Clinic: the Potential of Therapeutic Targeting of the IL-22 Signaling Pathway in Atopic Dermatitis TLR4 CCR6 CCL20 IL23R PMC6434849__F7 Interesting putative mechanisms are identified by iPathwayGuide (www.advaitabio.com) on the Glutamatergic synapse and the Chemokine signaling pathways TH IDE SYP CLU DAO PMC8042267__F3 IL23 in the development and activation of Th17 cells IL17A IL6 IL23R PMC4786287__F1 Altering the Mitochondrial Fatty Acid Synthesis (mtFASII) Pathway Modulates Cellular Metabolic States and Bioactive Lipid Profiles as Revealed by Metabolomic Profiling OXSM HTD2 ACSF3 PMC8042267__F4 Therapeutic approaches targeting IL23 and IL17 signaling IL17A IL23R IL12RB1 PMC12251195__F2 Programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1)-mediated immune evasion in the tumor microenvironment KRAS LAG3 PMC6445045__F1 Schematic representation of the unfolded protein response (UPR) SP1 SP2 ATF4 XBP1 PMC8042267__F1 IL23 signaling in Crohn’s disease STAT3 IF2B1 STAT4 IL17A IL23R IL12RB1 PMC8042267__F2 IL23 mediated resistance to apoptosis of mucosal CD4+ T cells in anti-TNF refractory Crohn’s disease patients STAT3 IL23R PMC11551676__F1 Wnt signaling pathway IFNG APC CTNNB1 PMC11641910__F1 Network of protein interactions involving p21 in diverse cellular processes STAT3 CABL1 PCNA TSG101 MDM2 SET PMC11641910__F2 Various metabolic pathways involving p21 EGF RRAD EGFR TIGAR PMC4663607__F1 Effects of vitamin K antagonists and direct oral anticoagulants on coagulation TF F2 GLA PMC9000741__F2 Extracellular HSPs: The Potential Target for Human Disease Therapy IL15 TLR4 CD14 PMC3606632__F6 MTOR signaling pathway in KEGG pathway analysis RHEB TSC2 EIF4B RICTOR BRAF MTOR EIF4E PMC7352604__F4 Wt TP53 LUAD females are enriched in antigen processing and presentation pathways with links to longevity IFNG HEL-S-99n TAPBP CANX SUSD3 CTSH HLA-DRB1 B2M TNF PMC102215__F1 Pathways to Lignin Monomers.The “metabolic grid” shown in this scheme incorporates the results of recent studies suggesting previously unexpected substrate specificities for F5H and COMT (; ; ) CAD COCH PMC5179106__F3 A) Protein-protein interaction analysis of 524 AD-related proteins revealed two large protein clusters: the APP network (14 yellow nodes) and the CAD network (11 red nodes) CAD GAD1 GFPT1 GAD2 PMC9550168__F6 SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway SNAI1 IGF1 IGF1R ZEB2 PMC7868988__F1 The main cellular pathways regulated by NNMT NNMT NAMPT SIRT1 PMC1475580__F1 Sequence of events in ATM→ ATR dependent signaling of DSBs in S/G2 cells ATR ATRIP ATM PMC5593528__F8 Loss of p16INK4A stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway TFAM CDK6 CDK4 PMC6256083__F5 Proposed anti-inflammatory pathway of beauvericin (BEA) in macrophages (adapted from Yoo et al., ) SYK TLR4 SRC IL1B MYD88 PMC10495754__F1 RIPK3-CaMKII-mPTP signaling pathway RYR2 GLUD1 RIPK3 PYGL RIPK2 PIG59 TRADD MLKL RIPK1 MCU TRAF2 FADD PMC7343132__F6 Comprehensive RNA-Seq profiling of the lung transcriptome of Bashbay sheep in response to experimental Mycoplasma ovipneumoniae infection TLR8 IRAK1 IRAK4 IL1B MYD88 PMC7343132__F3 Comprehensive RNA-Seq profiling of the lung transcriptome of Bashbay sheep in response to experimental Mycoplasma ovipneumoniae infection CD40 TIRAP CD36 CD14 CPO IRF3 TRAF6 TNF RAC1 LBP FADD PMC2375600__F2 From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy STAT3 LEP FOXO1 INS PMC10981749__F8 Model for the induction of proinflammatory SASP by typhoid toxin ATF3 TBK1 CGAS IFNAR2 IFNAR1 IL18 EIF2A PMC3412720__F3 JAK-STAT signaling pathway CSF3R CCND3 CSF2RB PIM1 CCND2 EPOR IRF9 CREBBP CISH MYC PTPN6 SPRY1 PMC8534790__F5 Review of Bioeffects of Static Magnetic Fields on the Oral Tissue-Derived Cells and Its Application in Regenerative Medicine COL1A1 PDE1C NFATC1 RUNX2 CTNNB1 PMC3412720__F4 AKT signaling pathway PDPK1 NFKB1 NFKBIA CHUK PPP2CA IKBKG PMC6046223__F8 Signaling pathway which miR-21 can regulate multiple functions in astrocytes SMAD2 PTEN MTOR PMC7762545__F4A Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach CDC42 PIK3CA BAD RAF1 PXN NFATC2 PIK3R3 PIK3CD PIK3R2 PPP3R1 AKT3 PIK3R1 SHC2 PPP3CA SH2D2A PPP3CC RAC3 PRKCB PLCG2 SPHK2 PRKCA APP KDR SRC CASP9 PTGS2 VEGFA KRAS RAC1 HRAS HEL-S-102 MAP2K1 MAP2K2 PMC8658239__F2 Important Role of Endothelium and Extracellular Vesicles in the Cellular Mechanism of Aortic Aneurysm Formation SMAD2 VCAM1 ARHA TRAF2 PMC3057454__F2 Autophagy in Immunity and Cell-Autonomous Defense Against Intracellular Microbes WIPI1 ULK1 WIPI2 MTOR PMC2925029__F3 The IFN-λ receptor signaling pathway IFNK STAT1 STAT2 IFNAR2 IFNAR1 MX1 JAK1 TYK2 PMC7506081__F2 Sterol regulatory element-binding protein (SREBPs) mediate the uptake, efflux, and storage of cholesterol ABCG1 FAS LDLR PMC2168342__F7 Matrilysin and stromelysin-2 differentially control apoptotic transcriptional response GSK3B PIK3R1 HIF1A IRAK2 MYC BCL10 STAT5B BMF HEL-S-44 CSF2 MMP10 CASP12 VEGFA TNF RAD21 BAG3 MAP3K7 BCL2 DIABLO HTRA2 HEL-S-103 BAD FAS ERCC2 SPHK1 PTEN DIDO1 NR1B3 BTG1 RIPK2 LITAF HIPK2 CARD10 RARB CASP4 UNC5B IRAK3 SIVA1 RIPK1 APP YWHAG BIRC3 NGFR IL6 ARHA RHOB MUC2 CASP3 DDIT3 FADD PMC11004224__F7 PM2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study TF IFNG HEL-S-133P TLR4 HEL-S-162eP EPO HEL-S-87p VHL PMC7506081__F3 Sterol regulatory element-binding protein (SREBPs) is involved in the activation of M1-type macrophages ACLY CCL3 TLR4 CCL2 MYD88 PMC7506081__F4 In tumor cells, the glucose uptake is significantly increased ACLY STAT3 OGT KEAP1 FOXO1 FASN LDLR SLC25A1 MTOR PMC11004224__F5 PM2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study LPL UBC HEL-S-28 PLTP PMC4697149__F1 Enhanced inflammatory gene expression by IL1B; feedback control by DUSP1 and feed-forward control by ZFP36 ZFP36 TNF IL1B PMC11004224__F8 KEGG network diagram of cytokine-cytokine receptor interactionLarge white box: biological pathway map LTB CNTFR LTA TPO XCL2 TNF TNLG7C PMC6214980__F7 Sex-associated function of epithelial STAT3 signaling in K-ras mutant lung cancer STAT3 CXCL1 ARG1 CCL2 CCL1 PMC8507033__F4 Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining GDF5 STAT3 TCF7L2 TLR4 IRAK1 TRAF6 PMC5781259__F2 Construction and analysis of the HEV-host PPI network EEF2K EIF2AK4 EIF2S1 EIF4A2 EIF5B EEF1A1 EIF4A1 EEF1A2 GSPT2 EIF4EBP2 EIF4EBP3 EIF2B1 EIF4B PAIP1 EIF2B5 EIF2B3 EIF2B2 EIF4EBP1 EIF1AY EIF1AX EIF2AK1 EIF2S2 EEF1B2 EEF1G EIF5 EIF2S3 ETF1 PABPC1 EIF4G1 EEF2 PPL PMC8507033__F2 Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining HOXD10 BAX FOXO1 EEF2 PTEN MTOR TSHZ3 PMC8507033__F3 Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining STAT3 TCF7L2 FOXO1 IRAK1 PTEN MTOR TRAF6 PMC8102118__F6 Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy SMAD2 SMAD4 PMC11621219__F4 Immunostimulants regulating adaptive immune responses by activating TLRs TLR1 IL10 TLR3 TLR4 TLR9 TLR5 IRF3 IRF7 MYD88 PMC12012963__F1 Simplified schematic of de novo nucleotide synthesis HEL107 CAD UMPS DHODH PMC5486142__F2 Adiponectin signal transduction implicating a cross talk with the insulin signaling pathway: Insulin and adiponectin interact with their respective receptors, which trigger a cascade of signaling events APPL1 ADIPOR1 ADIPOR2 PTEN PMC6360685__F2 The mechanism of miR-34 in EMT STAT3 MDM4 SMAD4 LEF1 CTNNB1 TGFBR1 PMC6534557__F5 Directed acyclic graph (DAG) of the 10 most enriched Gene Ontology (GO) terms and cytokine–cytokine receptor interaction pathways based on KEGG analysis AEN PMC5039587__F1 Toll-like receptor 4 (TLR4) signaling pathway in porcine intestinal epithelial (PIE) cells JUN TLR4 TAB3 MAL CD14 SIGIRR IRAK2 TRAF6 IRAK4 FOS MYD88 PMC4255921__F1 Canonical and non-canonical TGFB signaling SMAD2 SMAD4 DROSHA PMC5039587__F2 Toll-like receptor 4 (TLR4) signaling pathway in porcine intestinal epithelial (PIE) cells by acidic (APS) and neutral (NPS) exopolysaccharides produced by Lactobacillus plantarum N14 and Lactobacillus delbrueckii TUA4408L NPS JUN TLR4 TAB3 MAL CD14 SIGIRR IRAK2 TRAF6 IRAK4 FOS PMC3134613__F6 Specificity in neuronal activity-regulated gene transcription CLCA1 EPHB2 FOXO3A BDNF FOS PMC11186373__F8 Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12 SLC6A12 GSDMD SGK1 PMC3035094__F6 Cic regulatory elements mediate Torso and EGFR responses TG CIC EGFR PMC3285553__F3 Additional mechanisms by which Wnt/Beta-catenin signaling can be modulated in cancer HGF APC SMO NOTCH1 CTNNB1 PMC3285553__F4 Schematic illustrating numerous small molecules and biological compounds identified in the literature that inhibit Wnt/Beta-catenin signaling at various points in the pathway DKK3 SFRP4 FZD8 APC GSK3B FZD7 CTNNB1 PMC4878148__F1 Genomic Landscape of Response to EGFR Blockade in Colorectal Cancer EGFR PDGFRA BRAF ERBB2 PTEN PMC6801973__F3 Entamoeba sulfolipid metabolism DIO1 SF1 PMC9641939__F6 Effects and related mechanism of alpha-adrenergic receptor inhibitor phentolamine in a rabbit model of acute pulmonary embolism combined with shock PLN HEL-S-11 PMC4231433__F1 Wired on sugar: the role of the CNS in the regulation of glucose homeostasis POMC MC4R AIP MTOR PMC11141639__F1 Winer et al JAK1 MYC PLK1 PMC5526760__F5 Summary of gene function and epistatic interaction of the IL-10/STAT3 signaling pathway in pediatric inflammatory bowel disease STAT3 IL10 IL10RA JAK1 TYK2 IL10RB PMC2674015__F2A Toll-like Receptors: Novel Pharmacological Targets for the Treatment of Neurological Diseases TBK1 TIRAP TLR4 MAL IRAK1 IRF3 TRAF3 TRAF6 MYD88 PMC8050341__F3 Lactate and amino acid metabolism in Tregs SLC5A12 GLS CD36 AHR FOXP3 ARG2 GPT CIT PMC2657110__F2 HIV-1 modulates the interferon-induced antiviral host mechanisms, protein kinase R and 2',5'-oligoadenylate synthesis ELF2 RNASEL RAC1 PMC8050341__F1 Mitochondria and fatty acid metabolism in Tregs ACLY FAS FABP5 C2 ENO1 FOXP3 PMC4825590__F1 Crosstalk between cell cycle regulators and cellular metabolism CDK6 APC CCND1 CDK4 PMC7609160__F1 Hippo Signal Transduction Mechanisms in T Cell Immunity LATS1 DOCK8 LATS2 FOXO1 APC GSK3B LRP5 RAB13 LRP6 ARHA CTNNB1 PMC6177401__F4 Dengue virus and the host innate immune response TBK1 CGAS MAVS TLR3 IRF3 IRF7 TLR7 TRAF3 TRAF6 DROSHA MYD88 PMC6177401__F5 Dengue virus and the host innate immune response STAT1 HEL-S-62p STAT2 UBR4 C1S JAK1 C4B_2 TYK2 PMC6177401__F2 Innate immune response to DENV infection TBK1 CGAS MAVS IRF3 IRF7 TLR7 TRAF3 TRAF6 DROSHA MYD88 PMC4364715__F4 Novel Genetic Locus Implicated for HIV-1 Acquisition with Putative Regulatory Links to HIV Replication and Infectivity: A Genome-Wide Association Study FRMPD1 BCL2 PMC6177401__F3 Dengue virus and the host innate immune response C6 STAT1 STAT2 TLR4 IRF9 C9 JAK1 C4B_2 TYK2 PMC3597092__F3 Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR FGF8A FAS BAAT CYP7A1 UGT2B4 SULT2A1 PMC3493824__F1 Cellular Targeting in Autoimmunity CD2 PMC3493824__F2 Cellular Targeting in Autoimmunity CCR5 CD22 CCR1 PMC2583357__F1 ALTERATION OF AKT ACTIVITY INCREASES CHEMOTHERAPEUTIC DRUG AND HORMONAL RESISTANCE IN BREAST CANCER YET CONFERS AN ACHILLES HEEL BY SENSITIZATION TO TARGETED THERAPY RHEB TSC2 JUN BAD RAI1 TSC1 HEL-S-28 PTEN MTOR SRC FOS EIF4E PMC2583357__F3 ALTERATION OF AKT ACTIVITY INCREASES CHEMOTHERAPEUTIC DRUG AND HORMONAL RESISTANCE IN BREAST CANCER YET CONFERS AN ACHILLES HEEL BY SENSITIZATION TO TARGETED THERAPY TSC1 PTEN CS PMC5839390__F6 NFAT-mediated defects in erythropoiesis cause anemia in Il2−/− mice EPOR KLF1 EPO NFATC1 PMC11354414__F3 Cell signaling pathway involving TNFA in activating NFKB TBK1 MAP3K7IP1 RIPK1 TNF PMC9685446__F9 Fatty Liver/Adipose Tissue Dual‐Targeting Nanoparticles with Heme Oxygenase‐1 Inducer for Amelioration of Obesity, Obesity‐Induced Type 2 Diabetes, and Steatohepatitis TG FASN SIRT1 PMC11546156__F1 Brief molecular mechanisms of the autophagy signaling pathway ATG10 ATG3 ATG12 ULK1 UVRAG ATG14 ATG5 ULK2 PMC11718791__F1 PI3K pathway and FDA-approved, or fast-track designation-granted PI3K inhibitors TSC2 TSC1 PTEN PMC11718791__F2 PI3K, cell cycle, and ER pathways crosstalk in HR+ HER- BC CDK6 TSC1 PTEN CCND1 CDK4 PMC6785146__F3 Mechanism of alterations in the TSPO-mediated mitophagic signaling pathway and NLRP3 inflammasome activation in bipolar disorder STAT3 PINK1 IL18 PBR IL1B PMC8417405__F2 Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation HRAS TSC2 ATR TSC1 IGF1 ATM PTEN MDM2 PMC5183627__F1 TGR5 regulates different cell signaling pathways STAT3 TRPA1 ITCH GSK3B ARHA RHO PMC6908786__F4 Different signaling pathways triggered by different iNOS inducers that regulate iNOS expression (left: activation of NFKB pathway; right: activation of JAK/STAT-1A pathway) TLR4 TRAF6 MYD88 PMC5334258__F3 Trafficking pathways of E-cadherin VPS35 SNX1 SCRIB NOSTRIN PMC3782064__F2 Ingenuity pathway analysis GLDC ATXN3 ZNHIT3 SACS EXOSC1 TNFRSF19 PILRB PILRA TUBB4B STAG1 SREK1 TCF2 PTPRC RCOR1 TYMS ACACA NEK9 TRAF3 CD99 FBXW7 COLEC12 CEBPG HSF1 MICA PGAM1 CEBPA ZGPAT WNT3 FOXA2 CCNK HNRNPC TRMT2A AATF PMC7247259__F1 Biogenesis, structure, release, and uptake of exosomes CD2 CD63 PMC8933076__F1 Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases CYP8B1 CYP7A1 GCA HSD3B7 CYP7B1 CYP27A1 PMC9068303__F8 N-((1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methylene-3-oxo-olean-12-en-28-amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch-Akt Signaling Pathway STAT3 MTOR CCNB1 CCND1 PMC8567988__F6 Flavonoid Library Screening Reveals Kaempferol as a Potential Antiviral Agent Against African Swine Fever Virus ATG12 ULK1 ATG14 DEPTOR PMC9597993__F6 Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy TGFB1 MTOR PMC6342515__F1 Therapeutic potential of NAD-boosting molecules: the in vivo evidence NAPRT HEL-S-90n NMNAT1 MAL NMNAT2 NAMPT SLC7A5 SLC22A13 SLC5A8 NOX4 SARM1 SLC36A4 NADK NMNAT3 PMC8933076__F3 Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases CYP46A1 CCL2 PMC5755497__F10A Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation AURKA PPM1D ATR PLK1 TRIP12 MDM4 C13orf34 WEE1 CHEK2 CHEK1 ATM RPRM EP300 MDM2 PMC7725656__F2 Diverse ubiquitin codes in the regulation of inflammatory signaling SHARPIN TRADD OTULIN RELA RIPK1 ATF2 TNF CYLD TRAF2 PMC12128541__F8 Proposed mechanistic pathway for HDAC3 in mediating psoriasis HDAC3 CGAS TNF PMC3518543__F4 NFKB activation pathway is regulated by S-nitrosylation TIRAP TLR4 SRC MYD88 PMC4789422__F6 Module network of the core network biomarkers in to investigate the bladder carcinogenic mechanisms from stage 1 to stage 4 bladder cancer cells TF JUN UBC COPS5 ECT2 HEL-S-269 HEL-S-89n TNF FOS GTF2A1 KPNA2 FAF2 HEL-S-99n ADRM1 RPS20 C17orf95 SUMO2 PAAF1 HEL-S-125m DNAJB11 BAG6 PMC12087080__F2 miR-155 participates in multiple cellular functions STAT3 SMAD4 IL6 ARHA JAK1 VHL PMC4789422__F7 Carcinogenic mechanisms from normal to stage 1 bladder cancer cells (a), and from stage 1 to stage 4 bladder cancer cells (b) FAF2 HEL-S-99n RPS20 UBC PSMD12 SUMO2 DNAJB2 ECT2 TNF PSMD2 PMC12087080__F3 Mechanistic overview of miR-155 in regulating insulin signaling and glucose metabolism SOCS1 TLR4 PDC PMC5133817__F1 Argon’s molecular mechanism STAT3 BAX TLR4 MTOR IRAK4 MYD88 PMC3140053__F1 Genetic Polymorphisms in Inflammation Pathway Genes and Prostate Cancer Risk STAT3 CXCL12 IL10 COX2 IL6ST IL6 CXCR4 TNF PMC8033157__F3 Immune evasion by coronaviruses TBK1 CGAS MAVS STAT2 IRF9 RNASEL IRF3 IRF7 TRAF3 TRAF6 RAC1 ADAM17 TLR4 ISG15 NF2 TYK2 ACE2 PMC9655478__F10 L-Citrulline Supplementation Restrains Ferritinophagy-Mediated Ferroptosis to Alleviate Iron Overload-Induced Thymus Oxidative Damage and Immune Dysfunction GPX4 IL1B HEL-S-44 PMC8033157__F1 Induction of type I IFNs in response to viral infections TBK1 CGAS MAVS TLR9 RNASEL IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 RAC1 MYD88 TLR3 INF2 TLR4 TLR8 PMC9596766__F1 Two faces of DNA oxidation in genomic and functional mosaicism during aging in human neurons OGG1 TET1 MUTYH PMC3616892__F6 MTOR in CD4+ T cell differentiation STAT3 SOCS5 STAT4 SOCS3 FOXP3 GATA3 PMC3535427__F1 Targeting 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) for colorectal cancer prevention and treatment LTB LTA LOX COX1 PMC10873211__F9 Nasal Administration of bFGF-Loaded Nanoliposomes Attenuates Neuronal Injury and Cognitive Deficits in Mice with Vascular Dementia Induced by Repeated Cerebral Ischemia‒Reperfusion BAX KEAP1 NQO1 PMC7408653__F1 Wnt Signaling Pathway Activation and Inhibition APC GSK3B CTNNB1 PMC9359433__F1 RET signaling pathway and RET inhibitors in human cancer STAT3 PSPN FRS2 GDNF ARTN NRTN IRS1 DOK1 SHANK3 GRB7 GRB10 GFRA3 GFRA2 GFRA4 DOK3 GRB2 SRC DOK4 DOK5 RET PMC9359433__F2 RET signaling pathway and RET inhibitors in human cancer STAT3 RET PMC9265429__F3 Interaction of mTOR and Nrf2 in Neurogenesis and Its Implication in Neurodegenerative Diseases RHEB MLST8 TSC2 TSC1 KEAP1 DEPTOR PMC7532973__F8 Schematic presentation of the mechanisms triggered by HAS3-induced EVs in target cells CD44 EGF DHH HAS3 IHH PMC3191937__F3 Local regulatory proteins that mediate some of the actions of TGFB in human myometrium and leiomyoma RUNX1 RUNX2 CTGF PMC3169542__F7 Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD MAVS TLR3 IRF3 PMC3466241__F7 Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway KEAP1 MAF PMC11915071__F3 Biological roles and molecular mechanism of circular RNAs in epithelial-mesenchymal transition of gastrointestinal malignancies OXCT1 FUS STAT3 SMAD2 APC GSK3B SMAD4 HAMP ADAM10 DOCK5 CTNNB1 PMC4816192__F1 Targeting of BCR and PI3K/AKT signaling as therapeutic strategy in CLL ROR1 SYK BCR PLCG2 BLNK IGF1R LYN MTOR PMC6287618__F1 Role of EGF Receptor Signaling on Morphogenesis of Eyelid and Meibomian Glands ASB1 HBEGF TGFA MAP3K1 EGFR ARHA FGF10 PMC8472426__F6 HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells HEL-S-102 ELF2 ATF4 EIF2A XBP1 PMC6862663__F1 Gut dysbiosis/permeability increase circulating LPS and exosomal HMGB1, leading to TLR activation in microglia and the induction of iNOS and superoxide HMGB1 PDC AANAT AHR ASMT PMC8047311__F2 Pathogenesis of AAV and the inhibition of the binding of biological agents CD80 CDS2 HEL-S-62p TNF MPO PMC9206211__F2 Classic Signaling Pathways in Alveolar Injury and Repair Involved in Sepsis-Induced ALI/ARDS: New Research Progress and Prospect STAT3 FGF21 MSC ARG1 MTOR SIRT1 PMC2741134__F2 Inteferons pen the JAK-STAT pathway IFNGR2 IFNGR1 STAT2 IFNAR2 IFNAR1 TYK2 PMC8593085__F6 An In-Depth Review of Niraparib in Ovarian Cancer: Mechanism of Action, Clinical Efficacy and Future Directions TBK1 CGAS APC IRF3 SLC19A1 PMC4833639__F1 Many oncogenic mutations drive nutrient transporter gene expression CD36 PAK1 ULK1 PI3 AMT ARF6 RAC1 PMC3900493__F1 Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms LTB LTA ESAM LTBR ELL PMC3900493__F2 Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms LTB CD40 ICOS LTA LTBR CXCR5 PMC3900493__F3 Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms LTB LTA LTBR PMC2723867__F1 Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses CDC42 ZAP70 FYN BCR PLCG2 APC PC BLNK CD19 LYN RAC1 LCK PMC11853266__F4 Advanced glycation end products (AGEs) induced inflammatory cell signaling pathways CDC42 TIRAP ARHA RAC1 PMC11853266__F5 TLR4 signaling pathway in DPN TLR4 CYLD HES1 NOTCH1 MYD88 PMC7072649__F1 Pre-B cell leukemia (PBX3) is a target and a regulator of multiple signaling pathways FLT3 HMGA2 TRIB2 PBX3 APC SOX2 PTEN IL6 MMP9 MYC PMC7867516__F7 Related mechanism responsible for isoflurane-induced proliferation of squamous cervical cancer cells PCNA MTOR HDAC6 PMC5553593__F7 Interaction network of lysine-succinylated proteins in D C2 SET PMC6299239__F2 Tankyrase-mediated Wnt/Beta-catenin signalling RNF146 APC CTNNB1 PMC12122448__F2 Biological processes and genes involved in the Apelin Adipocyte Signaling Pathway, significantly activated by the DOP diet GNA11 APLN LIPE HIF1A PMC9360879__F5 IL-13 alleviates idiopathic pulmonary hypertension by inhibiting the proliferation of pulmonary artery smooth muscle cells and regulating macrophage infiltration MRO MAL BOK ING1 PMC10968029__F1 Illustration of GRB2 in humans and other organisms, highlighting its role in signal transduction and depicting the subcellular localization of GRB2 CBL RAD51 MRE11A RBBP6 PTEN GRB2 PMC6348509__F1 Targeting LCSCs by suppression of autophagy and Nanog.Autophagy positively regulated LCSCs by suppressing p53 and favoring the activity of Nanog STAT3 AURKA CD24 HGF TLR4 NUMB ABCG2 TWIST1 ABCB1 PMC10610230__F7 Mechanism underlying the therapeutic effect of PT on IDD ACAN JUN EDN1 PTGS2 TNF FOS COL2A1 PMC10968029__F3 Diagrammatic portrayal of GRB2 splicing variants, particularly GRB3-3, in signal transduction GRB2 HNRNPC ADA PMC10968029__F4 Configuration of GRB2 in Protein Interaction and Signal Transduction CBL EGFR PRR14 MTOR SRC GAB2 IRS1 PMC8357504__F3 Genome-Wide Expression Difference of MicroRNAs in Basal Cell Carcinoma BAX DDB2 POLK GSK3B BMP2 DVL3 SMO BAK1 CTNNB1 GLI3 PMC12003390__F1 Crosstalk between benign non-immune cells and cancer cells STAT3 CXCL12 LIF PC SRC CXCR4 CXCL8 PMC5860944__F2 Epidermal growth factor receptor (EGFR) and EGFRvIII in glioblastoma (GBM) PCNA NF1 EGFR LIF PTEN PMC2946881__F1 Regulation of adipogenesis by canonical Wnt signaling cascade APC LRP5 CTNNB1 PMC8842579__F3 Battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies TBK1 SYK MAVS IFIT1 IFIT2 TRAF3 TRAF6 STAT1 BCL10 ZBP1 TLR4 IFITM3 CH25H B4GALT5 IFNLR1 STAT2 IRF9 FASN IFITM1 RNASEL DNAJC6 IRF3 SPATS2L LY6E TLR3 IFNAR2 ELF1 IFNAR1 JAK1 TYK2 IL10RB CARD9 PMC8842579__F4 Battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies SYK TBK1 MAVS STAT2 IRF9 IRF3 TRAF3 MYD88 STAT1 IFNAR2 TLR4 IFNAR1 JAK1 TYK2 PMC9346148__F1 腺苷/A2AR信号通路阻断在肿瘤治疗中的应用 ADK ADA PMC6558049__F9 Possible mechanism of CAPE-pNO2 inhibits TNBC growth and metastasis CDH2 STAT3 EGF EGFR VEGFA PMC3999750__F4 PAR1 and PAR2 modulate TLR3-dependent expression of IFNB in CFs TF TLR3 IRF3 PMC11754051__F7 Interferon alpha production by the MAGUK-family protein CASK under H5N1 infection CDK5 TNK1 CCT4 IRF7 CASK HEL-S-94n TAF15 PMC8790852__F1 Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer CD44 STAT3 CRK PLCG1 HGF EGFR GRB2 MTOR SRC CTNNB1 PMC7025585__F1 Bat cells mount an antiviral response to RNA viruses, but limit the expression of inflammatory cytokines RIGI MAVS NLRP3 STAT2 IRF3 TLR7 TNF PMC10564428__F8 Myeloid-specific knockout of SHP2 regulates PI3K/PLCG signaling pathway to protect against early myocardial infarction injury IFNG TNF MERTK MYD88 PMC4177028__F2 Intracellular energetic units (ICEUs) CD36 AK2 AK1 MAL PMC11721226__F2 TGFB/SMAD4 signaling pathway in immune cell; A The TGFB/SMAD4 signaling pathway promote the differentiation of naive CD4+ T cells into Th17 cells and regulatory T cells (Tregs) SMAD2 PMC7025585__F2 Exogenous and self-DNA sensing pathways are dampened in bat cells RIGI NLRP3 STAT2 TLR9 AIM2 MNDA PMC7330108__F2 Cancer cell death induced by Apoptin APC CDK2 BCL2 MMP9 MTOR APAF1 PMC3134994__F1 Schematic Illustration: TGF-beta signaling pathway SMAD2 SMAD4 PMC4542378__F1 Signaling networks activated during primary KSHV infection as analyzed by Kinex antibody array and IPA TRADD INSR EGFR MDM2 GRB2 SRC CEBPB TRAF2 IRS1 PMC3043627__F1 Simplified model for the intersection of signaling pathways regulating protein synthesis and degradation GSK3B MTOR EIF4E PMC2891946__F7 Crosstalks between EPCR, PAR-1, S1P1, and Tie2 TH PC ARHA RAC1 PMC6985208__F2 Signaling pathways associated with highly differentiated proteins in X spermatozoa UQCRC1 ACACB COX2 HEL-S-133P HEL-S-49 HEL-S-162eP HEL-S-278 PMC8091149__F6 Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function ECSIT SAA1 IL17F STAT3 JUN TIMP3 IL1A TNF IL17RA COL6A1 PLAT IL17C MAP2K4 RALA SERPINE2 INHBE SELS SCARB1 RELA RIPK1 PMC6985208__F3 Signaling pathways associated with highly differentiated proteins in Y spermatozoa PDHX GSTM3 DNAI2 CAPZB EFHC1 TUBA8 PMC7279580__F6 Zika virus dysregulates human Sertoli cell proteins involved in spermatogenesis with little effect on tight junctions EGF PGAM1 TIMP1 IGF1 IMPACT PMC1234333__F7 Knockdown of Smad4 affects only a subset of TGF-Beta-regulated target genes and functions SNAI2 CITED2 ADAM19 JUNB SMAD4 NET1 GATA3 ITGB6 SMURF1 RUNX1 GADD45B DLX2 ELK3 AKAP12 HES1 SOX4 PMC5322275__F3 Schematic model summarizing the findings of the proteomic and metabonomic profiling analyses DLG2 BSN GRIA3 GRIA2 VAMP2 TBX1 GSK3B DLG4 MTOR RHO DGCR8 TXNRD2 CAMK2G HIRA PMC10551897__F11 KEGG pathway diagram for PI3K-AKT signalling pathway SYK TSC2 BAD BCR BRCA1 RBL2 CD19 PTEN IRS1 PMC4727329__F7 MILP model identifies causal relationships from PI3K/AKT and TP53 pathways (KEGG) (a) PI3K/AKT pathway is altered in phase 1 of breast cancer progression; (b) TP53 pathway is altered in phase 2 of breast cancer progression PIK3CA IGF1 PTEN MTOR PMC10551897__F12 KEGG pathway diagram for EGFR tyrosine kinase inhibitor resistance pathway EGFR BRAF PTEN SHE PMC10551897__F13 KEGG pathway diagram for MAPK signalling pathway MAX ECSIT TH FAS TRADD CD14 GRB2 TRAF6 TNF TRAF2 PMC4982440__F6 Proposed Model of PI3KA Resistance in SGK1-Expressing CellsPIK3CA-mutant breast tumors depend on the PI3K pathway, which mainly signals through AKT RHEB TSC2 SGK1 PMC4108926__F2 Melanoma and integrated Breast cancer pathway landscape TES FAS ATM ME1 PMC2724002__F2 Controlling Hair Follicle Signaling Pathways through Polyubiquitination SHH GLI3 PMC2766659__F4 Signaling molecules and pathways regulating the fate of spermatogonial stem cells LHX1 GDNF BMP4 SMAD4 SRC PMC11506536__F2 Illustrates the multifaceted mechanisms of action of niclosamide in cancer treatment RHEB STAT3 RICTOR APC GSK3B MTOR OTP PMC9367165__F2 Twinkle twinkle brittle star: the draft genome of Ophioderma brevispinum (Echinodermata: Ophiuroidea) as a resource for regeneration research HDAC1 MESP2 NEDD4 ACBD3 LNX2 NUMB POFUT1 FURIN PMC8086092__F12 Comparative transcriptomic analysis reveals the regulatory mechanism of the gibberellic acid pathway of Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn.) dwarf mutants GAL GAS SKP1 PMC9212771__F6 In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19 BAD SP1 HEL-S-62p LIF OBI1 PMC6702832__F5 Modulation of the NFE2L2 pathway in keratinocytes MAF NFE2L2 SFN AHR PMC6263799__F1 Summary of the current model of the GET pathway GET1 GET4 GET3 PMC6702832__F6 Modulation of the NFE2L2 pathway in melanocytes MAPK1 KEAP1 MAF NFE2L2 PMC6702832__F7 The NFE2L2 pathway in fibroblasts MAPK14 MAF NFE2L2 SFN PMC2928959__F6 Hypothetical model for EGFR-dependent loss of cell polarity and activation of Wnt signaling in CS-exposed human airway epithelium EGFR APC LRP5 MUC1 LRP6 PMC5537818__F6 Underlying mechanisms of n-3 PUFAs protecting metabolic syndrome LPL TG FAS APOB MYD88 PMC12040899__F10 SUMOylation and SAFB2 in PDAC Progression AHNAK2 SAFB2 KRAS CTNNB1 PMC4871587__F3 Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis PLCG2 RRM1 HAS2 LFNG FGF5C GRB2 UTP11 MYC AZI2 PMC7082839__F7 Diverse APJ signaling pathways activated by prolonged mechanical load or apelin RYR2 PLN MTOR PMC3690588__F1 Wnt signaling BCL9 APC RHO CTNNB1 PMC2790152__F3 A model of the inhibitor of growth (ING) 2 signaling pathway RBP1 SIRT1 PMC7082839__F4 AT1R signaling pathways activated by prolonged mechanical load or Ang II ATR EGFR MTOR TRPC6 TRPC3 PMC2671642__F5 Comprehensive genomic characterization defines human glioblastoma genes and core pathways EGFR PTEN CDKN2B RB1 MDM4 CDKN2A CDK6 CDKN2C CCND2 NF1 PDGFRA ERBB2 MDM2 CDK4 PMC4881178__F7 Proposed pathway of ASPE signaling in MDA-MB-231 cells BAX CDK6 CDK2 CDK4 PMC5855681__F2 MicroRNAs regulate gene transcription SUZ12 DGCR8 AGO1 EZH2 YY1 DROSHA PMC3294426__F3A Into the Eye of the Cytokine Storm STAT3 TNFRSF19 SOS1 SOCS2 IRAK1 TCF4 SOCS3 MYD88 MAPK14 AHSG MAP2K6 C9 ORM1 HRG IL1A TNF HRAS MAP3K1 SOS2 MAP3K7 FGA MAP3K5 GRB2 TNIK TRADD MAPK13 SHC2 ORM2 TNFRSF8 TNFRSF18 TACI RBP2 SHC4 ITIH3 TNFRSF13C APOH RBP1 TNFRSF17 SAA2 NFKBIE RIPK1 CEBPB SHC3 ECSIT ITIH2 JUN C1S SOCS4 PTPN11 KRAS APOA2 SOCS7 MAP3K7IP1 HP MAP2K1 LBP NFKBIB PMC4081675__F1 Signaling pathways regulating hepatic stellate cell activation in alcoholic liver disease TLR4 SMAD2 SMAD4 BCL2 PMC1447421__F10 Hypothetical model describing the roles of Rad18 and PolK in the BPDE-induced S-phase checkpoint RAD18 ATR PCNA POLK ATM PMC7379175__F8 Model depicting the relationship between CIBZ, RB1CC1 and autophagy ATG101 ULK1 RB1CC1 PMC7477886__F3 Simulated network from genetic variant to disease constructed from the insulin signaling pathway from KEGG RHEB TSC2 BAD FAS TSC1 INSR FOXO1 GSK3B GRB2 PDK2 MTOR EIF4E PMC7477886__F4 Whole network from APOE genotype to AD constructed from KEGG-based Alzheimer’s disease pathway CASP9 BAD CACNA1C CASP8 TNFRSF1A CYCS APOE BACE1 RTN3 CASP3 ITPR2 ADAM10 PLCB3 FADD PMC2904682__F1 Schematic model of regulatory pathways involved in Mycn stabilization CDC2 RICTOR ALK GSK3A IGF1R PDK2 MTOR PIN1 PMC7407487__F4 Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney CASR WNK4 DCT PMC11706183__F8 Uncovering iron imbalance and inositol metabolism disruption: insights from the yeast model of N88S seipinopathy PC PIN1 INS PMC2883240__F1 Signaling pathways involving molecular markers for human breast cancer TBX2 ATR JUN PCNA DMP1 BRCA2 DHFR FOS BRCA1 ATM TBX3 MDM2 CCND1 CDK4 PMC2453756__F1 Pathway of murine Th17 differentiation TH IL25 FOXP3 PMC7569249__F5 Overexpression of Rab40b promotes hepatocellular carcinoma cell proliferation and metastasis by upregulating cyclin D1, cyclin E1 and MMP2 via PI3K/AKT signaling pathway CCNE1 MMP2 RAB40B CCND1 PMC2897739__F1 Recent advances in the genetics of systemic lupus erythematosus IKZF1 TNFAIP3 NCF2 PRDM1 TLR9 IRF7 IRF8 TRAF6 TNLG2B IFNG STAT1 ITGAM IFNAR2 IFNAR1 LYN JAK1 ATG5 TYK2 UBE2L3 FCGR2A PMC2752361__F3 MOLECULAR CONSTITUTION OF BREAST BUT NOT OTHER REPRODUCTIVE TISSUES IS RICH IN GROWTH PROMOTING MOLECULES CRK WT1 JUN FOSB VAV3 TUSC3 IGF1 FGF9 GHR PMC5557856__F6 Proposed mechanism by which CoQ10H2 improves metabolic function and inhibits insulin resistance in KKAy mice FAS NR1C1 SIRT1 PMC7140893__F6 Gene–gene interaction (GGI) and protein–protein interaction (PPI) predicted networks of DEGs enriched in the extracellular exosome post heat stress HEL113 TGFBI THY1 LAT DOCK2 ALB AHSG POSTN TUBA4A APOH KNG1 ITIH4 HSP90AB1 ICAM2 S100A4 A1BG CNDP2 DOCK10 DNAJB1 GNG10 SERP1 AMBP S100A6 CD14 IGFALS CD55 HEL-S-78p SPP1 APOA2 HEL-S-102 PTGES3 SIRPA FGA GNA13 PMC8939180__F4 Metabolome and transcriptome analyses identify the plant immunity systems that facilitate sesquiterpene and lignan biosynthesis in Syringa pinnatifolia Hemsl. IPP CAD MVD MVK PMC6523117__F7 Suggested mechanism of rFlaA:Betv1-mediated mDC activation STAT3 IRAK1 TLR5 MTOR TRAF6 IRAK4 MYD88 PMC9688731__F3 Extracellular Vesicles in Multiple Myeloma—Cracking the Code to a Better Understanding of the Disease EGFR MSC AREG MMP9 CXCR4 RUNX2 PMC6563125__F8 Model of interaction between an oncolytic virus and the host type I IFN response and cyclin expression STAT1 IRF9 CDK2 OAS1 PMC7825104__F3 Adrenergic signalling pathway and mechanisms LATS1 STAT3 SNAI2 BAD BRAF HIF1A MTOR PMC2713319__F1 Apoptosis and Epithelial Injury in the Lungs FAS FADD PMC1522081__F7 Involvement of MACF1 in the Wnt/Beta-catenin signaling pathway APC GSK3B PMC2713319__F3 Apoptosis and Epithelial Injury in the Lungs FAS TLR4 CD14 IL1B FADD MYD88 PMC7217787__F1 Rapamycin use in COVID-19 CD44 TH CD2 MAVS MTOR ACE2 PMC8053758__F4 Promising targets for therapy of osteoarthritis: a review on the Wnt and TGFB signalling pathways FOXO1 CLK2 SIRT1 PMC3753498__F9 Schematic representation of methionine metabolism via methionine cycle and transsulfuration pathway showing cysteine as a precursor of GSH and hydrogen sulfide (H2S) HEL-S-61p PMC5850680__F1 Under the action of BMP2 and inflammatory mediators such as tumor necrosis factor, the expression of transcription factors Runx2 and osterix can be activated via the BMP/Smad pathway CRP BMP2 LRP6 LRP3 TNF RUNX2 MSX2 PMC5913738__F2 Intermittent metabolic switching, neuroplasticity and brain health TFAM SIRT3 ULK1 MTOR BDNF NRF1 PMC5913738__F3 Intermittent metabolic switching, neuroplasticity and brain health SIRT3 MTOR BDNF SIRT1 FGF2 PMC11534336__F1 Schematic models of the core of MAPK/ERK pathway and human eIF3 complex RHEB EEF2K TSC2 TSC1 PAK1 GRB2 CCND1 ELF3 PMC2634257__F1 Simplified schemes of the three Wnt signaling cascades RHO LEF1 DAAM1 CTNNB1 PMC3111485__F5 A Large Gene Network in Immature Erythroid Cells Is Controlled by the Myeloid and B Cell Transcriptional Regulator PU.1 FOS GAB2 PMC5306369__F1 Complement activation and evasion by NS1 protein of flavivirus C6 C7 HEL-S-62p C1S C9 MNS1 C4A C4B_2 PMC10198710__F2 m6A methylases that participate in cancer glycolytic metabolic pathways PDK4 ENO2 HK2 ALKBH5 WTAP METTL14 YTHDF1 METTL3 BPTF PMC5774705__F3 Hybrid genome assembly and annotation of Paenibacillus pasadenensis strain R16 reveals insights on endophytic life style and antifungal activity FER RERE PMC9563266__F2 MARCKS in Metastasis and Treatment Resistance of Solid Tumors SOX2 MARCKS ERBB2 PTEN ARHA MMP9 ABCB1 PMC3315682__F1 Serine biosynthetic pathway PHGDH PSAT1 PSPH PMC4282831__F3 Seeing through VEGF: Innate and adaptive immunity in pathologic angiogenesis in the eye SEMA3A HEL-S-62p NRP1 CD55 IL1B PMC10198710__F3 m6A methylases that participate in ferroptosis TF SLC3A2 GPX4 SLC38A1 SLC7A11 YTHDF1 YTHDC2 TFRC TIAM1 ALKBH5 YTHDF2 METTL14 METTL3 IGF2BP2 PMC4339613__F3 Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment KEAP1 MAF VHL PMC1866211__F1 Hedgehog signalling pathway REN SPOP PMC6092617__F7 Targeting prohibitins at the cell surface prevents Th17‐mediated autoimmunity PHB2 IL17A FOXP3 PMC5727329__F2 DKK1 regulation of signalling pathways CKAP4 DKK1 APC LRP5 LRP6 RYK ARHA CTNNB1 PMC5823660__F3 An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice HEL-S-99n CANX BCL2 ATF4 XBP1 TRAF2 PMC8838622__F1 An Emerging Role of Defective Copper Metabolism in Heart Disease ATOX1 LOX ATP7B HEL-S-44 ATP7A CP PMC8472298__F2 Insulin and Insulin Resistance in Alzheimer’s Disease MTOR IRS1 PMC10907440__F2 Positive effects of SGK1 in embryogenesis SGK1 BMP7 VEGFA PMC2865489__F1 The estradiol-synthetic pathway and nuclear receptors STAR CYP11A1 PBR PMC2788159__F1 Regulation of mTORC1 mTORC1 is a multiprotein complex composed of Raptor, mLST8, PRAS40, and FKBP38 and regulates protein synthesis and cell growth by phosphorylating S6K1 and 4EBP1 RHEB TSC2 TSC1 MTOR EIF4E PMC8403639__F1 NRF2 signaling pathway KEAP1 GCLM NQO1 GCLC MAF PMC2788159__F2 Current proposed mechanisms of amino acid sensing by mTORC1 Amino acids are imported into the cells via various amino acid transporters and activate mTORC1 either by amino acid metabolites or by undefined membrane/intracellular amino acid sensor(s) RHEB TSC2 TSC1 PMC4303015__F2 microRNA-21 Mediates Stretch-Induced Osteogenic Differentiation in Human Periodontal Ligament Stem Cells LTBP1 BMPR2 TDP1 ACVR2B THBS1 DKFZp781O1323 PITX2 TGFBR2 ZFYVE16 BMP8A ACVR1C ACVRL1 SMURF2 PMC6506819__F3 Disease-Associated Genetic Variation in Human Mitochondrial Protein Import NDUFB10 YME1L1 OMA1 PMC11781172__F1 Novel representative therapeutic targets for SCLC AURKA TIGIT DLL3 CD47 LAG3 PMC7851145__F1 LPA intra- and extracellular biosynthesis and degradation LPA PLD2 PC PMC9578258__F2 Synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment CDC2 XPA TOPBP1 ATR RAD51 BRCA2 SSB PARP1 DDB2 DDB1 SMARCAL1 ETAA1 BRCA1 WEE1 CDK2 ATM PALB2 CDC25B PMC5294251__F7 Proposed model for the CD271 regulation and potential downstream effects mediating drug resistance and metastasis NGF FGF13 ATR RAD51AP1 H2AX PRKDC NEK2 ATM MDC1 TOP2A PMC8270677__F4 Replication Stress Response on a Narrow Path Between Genomic Instability and Inflammation RAD51 MRE11A TREX1 PMC5381059__F1 Cancer immunotherapies targeting the PD-1 signaling pathway CD40 ICOS APC PMC7125293__F4 Transcriptome analysis on fructose as the sole carbon source enhancing perylenequinones production of endophytic fungus Shiraia sp. Slf14 HEL107 DLAT COCH ADA PMC8422427__F6 Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications ATF4 EIF2A XBP1 TRAF2 IL1B PMC10902513__F2 TGFB/Smad signaling pathway involved in radiation skin fibrosis SMAD4 SMURF2 PMC8578301__F1 Clinical and biochemical footprints of inherited metabolic diseases. VI. Metabolic dermatoses. CERS3 UGCG SPTLC3 ELOVL1 KDSR ELOVL4 ELOVL3 SPTLC2 PHGDH ALOX12B SDR9C7 CYP4F22 SPTLC1 PSAT1 ALOXE3 SLC27A4 PSPH PMC8648894__F1 Signaling in the crowded cell RHEB CA3 EGFR TTI1 PTEN GRB2 MTOR DEPTOR MMD RAC1 SLC38A9 PMC5652738__F9 Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer STAT3 HGF EGFR PMC7403652__F4 KEGG pathway with significantly enriched differentially expressed proteins BAGE RFWD2 BAD FAS AIFM2 PGR PERP SIVA1 CDK2 ATM PTEN ME1 PMC4600925__F4 SGK1-mediated signaling pathway WNK1 SGK1 PDK2 PMC3289952__F1 Selected essential fatty acids molecular mechanisms ABCA9 ABCG1 ABCA1 PMC9387202__F10 The gut microbiota and lipidomic profiles by black chokeberry (Aronia melanocarpa L.) polyphenols via the glycerophospholipid metabolism signaling pathway LPCAT2 PLD2 PC PMC10561294__F7 Construction of PPI networks BCL2A1 MMP3 CXCL2 TNF CSF3 CCL20 CXCL3 PMC3289952__F2 Proposed role of essential fatty acids in “micromanaging” molecular actions GPR32 DGCR8 AGO2 CDKN1B PTEN DROSHA CEBPB PMC6437734__F6 VPA induces apoptosis in neutrophils and diminishes their phagocytic capacity BAX FPR2 PMC6437734__F8 VPA affects IL-12-, IL-15-, and IL-18-mediated IFNG production in NK cells IFNG JAK3 STAT4 MYD88 PMC6008067__F5 Proximity of Bcl-xl to p38, MK2, and RTN4 in platelet function STAT3 TNPO1 HNRNPA0 AGO2 HEL-S-21 ARPC5 AKT3 MAPK15 POR STAT1 PNP BAG2 FYN MAP2K6 STAT5B APP HEL-S-44 STAT2 LIMK1 ARHA HEL-S-47e TSC2 RTN4 HEL-S-102 YWHAZ PMC1592643__F3 An altered balance of proapoptotic and antiapoptotic molecules in trauma patients' T cells could indicate specifically increased vulnerability to apoptotic depletion HTRA2 BAD FAS CAD CD27 FAF1 GAS2 TNFRSF25 TNF ROCK1 DAPK2 APAF1 DIABLO PMC7232489__F2 Bifurcated pathway to synthesize hexanoic acid in M ACAT2 HBD PMC6172370__F8 P38 MAPK signaling pathway in the regulation of the NLRP3 inflammasome and macrophage pyroptosis NLRP3 IL1B PMC4908728__F8 Schematic showing the effects of RBE on LPS-activated microglia IL10 TLR4 IL1B MYD88 PMC6862352__F1 Hh in the ischemic skeletal muscle DHH SHH IHH PMC11077380__F2 Mechanism diagram illustrates the crosstalk between Se-AA metabolism and various cell types in the TME FAS HLA-E GPX3 GPX1 PMC10740873__F2 Ihh signaling pathway in regulating osteoblast differentiation (refer to Pan et al SOX9 PTCH1 IHH SMO RUNX2 GLI3 PMC11077380__F3 Antitumor application of Se-AAs SMAD2 BCL2 MICA MICB ULBP2 SSB PMC3733582__F3 Pathway Linker Results for AChE and BChE ACHE LAMA1 COL4A1 APP HAND1 BCHE LAMB1 COLQ PMC3830643__F2 Lipid Synthesis in Protozoan Parasites: a Comparison Between Kinetoplastids and Apicomplexans ELOA tmp_locus_29 ELOC PMC9284119__F5 Overexpression of TwSQS, TwSE, and TwOSC Regulates Celastrol Accumulation in Cambial Meristematic Cells and Dedifferentiated Cells POR IPP DDC PMC6010849__F10 Schematic overview of Nrf2 signalling crosstalk to both Wnt3a/B‐catenin and AMPK pathway in COPD/emphysema WNT3A NQO1 PMC2652645__F1A Detailed qualitative dynamic knowledge representation using a BioNetGen model of TLR-4 signaling and preconditioning RP1 TLR4 MAL CD14 IRAK1 TRAF6 TNF IRAK4 MYD88 PMC11048799__F5 Mechanism by which GAA promotes muscle development and growth through mirNA-targeted gene regulatory signaling pathway [27,43,44,47,48,49,50,51] HRAS GAA PDGFD PDGFA MTOR IGF2 EIF4E PMC5983927__F7 Antitumor effects of corilagin BAX FAS FADD PMC7817854__F2 miRNAs targeting SMO oncogenic hedgehog pathway to induce apoptosis in CRC EVC2 EVC DHH SHH IHH SMO PMC7261959__F12 Alterations induced on SIRT1/PGC-1A pathway by ABOs TFAM MFN1 NRF1 SIRT1 PMC6437734__F1 VPA inhibits LPS signaling in macrophages TAB3 CD14 PTEN MDM2 TRAF6 IRAK4 MYD88 PMC6741997__F8 Model of the neuronal death pathway involving Cdks CDK6 CDK5 CDK2 CDK4 HEL-S-44 PMC6437734__F2 VPA induces M1-M2 polarization of macrophages in response to LPS CD40 CD80 PMC6437734__F4 VPA inhibits monocyte to DC cell differentiation STAT3 CD83 CD80 IL4 IRF4 PMC9106028__F1 Front-Line Therapy for Metastatic Renal Cell Carcinoma: A Perspective on the Current Algorithm and Future Directions AXL APC CTLA4 MTOR PMC9343600__F11 Linagliptin in Combination With Metformin Ameliorates Diabetic Osteoporosis Through Modulating BMP-2 and Sclerostin in the High-Fat Diet Fed C57BL/6 Mice STAT3 DPP4 BMP2 GIP IL6 RUNX2 PMC7235440__F1 Herpesvirus host shutoff-associated proteins mediate evasion of the type I IFN signaling pathway (refer to ) TBK1 CGAS MAVS TLR3 STAT2 TLR9 IRF3 IFI16 IRF7 TRAF3 TRAF6 MYD88 PMC9641750__F6 Mitigation of Multi-Organ Radiation Injury with ACE2 Agonist Diminazene Aceturate IL10 ACE2 PMC8123313__F1 Leptin Receptor Compound Heterozygosity in Humans and Animal Models STAT3 FOXO1 POMC SOCS3 GRB2 PMC8196557__F6 miRNAs and Genes Involved in the Interplay between Ocular Hypertension and Primary Open-Angle Glaucoma. Oxidative Stress, Inflammation, and Apoptosis Networks APPL1 MAPKAPK3 GAS2 BBC3 RB1 SLC23A2 TRAF3IP1 TP53AIP1 PRSS56 MAPK8IP1 PAX2 IFT81 COL8A2 COL4A5 MMP2 ATF7 DAP FBN2 PTGFR FBLN2 APAF1 BCL2L13 BBS2 TDRD7 FBN1 CASP9 FOXE3 DCC POMT1 SIX1 MMP21 OPA1 SIX6 MMP17 CRYAA IRF1 IFT46 SSNA1 COL11A2 ITGB3 PAX6 ATOH7 IFT74 BCLAF1 ANGPT4 CRYBB2 RPGRIP1 MSRB3 TACC1 TP63 BCL2 DIABLO TGFB1 CD36 COCH MAP2 MDM4 COL1A1 FOXC1 LTBP2 THBS1 CYP1B1 XAF1 WDR36 MYOC C2 CYP11A1 C6 TGFBI COL4A3 C3AR1 GPX4 SPARC KALRN TRAF3 MMP11 ITGB6 BCL2L1 ITGA2 COL4A2 TPO MDM2 DCN TGFBR3 VEGFA LAMB2 COL5A2 MYO9B CDC42 TNC MMP14 FAS HEL-S-62p LOXL1 ARC ITGAV F2 PXDN OPTN CAV2 SERPINC1 GPC1 COL1A2 CASP2 GDNF IL6 XB CASP3 PMC9293517__F5 Explore the Therapeutic Composition and Mechanism of Schisandra chinensis-Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on Chemical Profile, Network Pharmacology, and UPLC-QTOF/MS-Based Metabolomics Analysis HEL-S-22 CYP1A2 ACHE TH JUN SELE PGR CHRM1 PTPN1 CHRM3 GSTM1 GABRA2 CHRM2 INSR F2 RXRA PTGS1 CHEK1 CDK2 PRSS1 KCNMA1 PMC3319358__F2 Gut triglyceride production TG DGAT1 ACAT2 DGAT2 SAR1B MGAT2 BLM VAMP7 PMC2668982__F2 CCN1 signaling and crosstalk with TNFA BAX CYR61 CASP8 TRADD CASP10 TRAF2 RAC1 FADD PMC6355473__F4 New targeted therapies in advanced primary cutaneous anaplastic large cell lymphoma STAT3 CD2 ALK AK2 AK1 AK3 NOTCH1 PMC7563957__F1 Simplified diagram of the 5-fluorouracil (5FU) conversion system TK1 RRM1 NT5E RRM2 TYMS TYMP PMC3319358__F1 Gut triglyceride production HMFN0839 DGAT1 GPAT4 DGAT2 BLM PMC6848764__F2 Working model for CILK1 signalling MLST8 SUFU OFD1 GSK3B IFT20 SMO DEPTOR GLI3 PMC6348090__F10 Transcriptome profiling reveals the role of ZBTB38 knock-down in human neuroblastoma ATR CDK6 CDK2 ATM PTEN PIGS MDM2 MTOR CDK4 PMC6607389__F3 Protein-protein interaction network complex and modular analysis CCL5 FLNA CXCL3 CDKN2A FOXQ1 B3GNT6 FAT10 NOS2 CES1 CXCL10 CXCL11 CRABP2 EDN1 CCL4L2 THBS4 REG1B Meflin ACTG2 PIGR AQP1 CHP2 PRSS8 OLFM4 AGPAT5 MXRA8 COL8A1 SPARCL1 FREM1 CES3 ARHGEF25 CXCL1 HTRA3 HTRA1 PTK7 FADS2 NTSR1 GGT7 HLA-DRB5 DEFA6 TNFRSF10A REG4 DEFA5 C6orf15 SYT7 HLA-DRA COL9A3 MUC20 PAP tmp_locus_29 DHRS12 SYNM ST6GALNAC1 MOGAT3 FHL1 HSPB7 LMOD1 CALB2 GNLY CTSF FOXA1 ANXA9 HEL-S-101 TNNC1 FSTL3 TNNC2 ASPN MAPRE3 HEL-S-90n MEGF6 ITLN1 NKD2 CST2 IHH RBP4 CST1 PDLIM4 DSG3 GBP1 TSC22D3 CACNG4 CYB5B SLC12A2 PPP1R14A LRRC26 KISS1 IGLL5 MFAP4 SERPINE2 MFAP2 FOLR1 MUC5B MGP RAMP1 DKFZp686P11128 SYT1 LTBP1 HEL164 RGCC MLXIPL TYMS MMP11 GBP4 CD74 DKK1 MAGEA6 PRELP HSPB8 VIP S100A4 TNFRSF11A SLPI ATOH1 SERPINA1 FOS HEL-117 SFRP4 CCL25 CDKN1C CCL4 PPL HEL-75 CXCL9 PLN COMP MMP14 FAS HEL-S-273 TIMP1 MSLN COL10A1 TNS1 pp6425 MYLK ACTA2 PDX1 HEL-S-14 EEF1A2 IL1B LGR6 CDCA2 EMILIN1 NKD1 GPC1 GNG4 GZMA BMP7 CXCL2 FNDC1 SULT2B1 IDO1 HEL-S-102 PMC3362922__F1 Hexosamine biosynthetic pathway and its dependent processes OGT SF1 SMS PGM3 PMC3281607__F2 Antioxidant roles of Prx I, Prx III, and Srx in ethanol-fed mouse liver CYP2E1 KEAP1 PRX PMC6219086__F5 DE genes on “Wnt Signaling Pathway and Pluripotency” pathway upon S DVL1 PRKD1 CTNND1 PRKCZ NR1C2 MYC PRKCH PRKCB CTNNB1 FRAT1 PRKCE PRKCA CRP NKD1 MMP7 JUN NKD2 APC SOX2 ARHA AXIN2 TCF3 TCF7L2 PRKCI PAFAH1B1 ZBTB33 PPP2R2A NFYA MAP3K7 CREBBP PPP2R3A EP300 MAPK10 PPP2R2D PMC12183286__F2 TREM2 signaling pathway (by Figdraw) CDC42 SYK LCP2 VAV3 SOS1 VAV2 LAT ddo BIN1 VAV1 RAC1 CTNNB1 MYD88 TREM2 ADAM17 CD2AP TLR4 SOS2 PC ADAM10 DOK3 GRB2 SRC LAT2 PMC6219086__F6 Insulin signaling pathway SOCS1 PIK3CA RAF1 SOS1 ARF6 GSK3B MAP3K11 MAPK9 SOCS3 MAPK8 MAPK3 MAPK14 MAP3K8 GRB10 CAP1 MAPK1 FLOT1 IRS1 RHEB TSC2 PRKCI TSC1 MAP3K1 PRKCQ SOS2 MAPK7 MAP3K7 MAP2K5 MAPK10 SNAP23 RRAD MAPK11 VAMP2 MAPK13 GYS2 PPP1CC SHC2 MAP3K14 XBP1 PRKCH CBLC GYG1 MAP2K3 MAP4K3 RAC1 CBL INPP4A IKBKB LIPE INPPL1 SNAP25 GRB14 MAP3K6 TBC1D4 STXBP3 EHD1 STXBP4 EHD2 STXBP1 KIF3A RAB4A MAP3K10 SHC1 MAP3K13 MAP3K12 ARF1 PIK3CD PIK3C2G PIK3C2A PRKCZ PTPRF FLOT2 MAP4K2 MINK1 SGK2 PRKAA1 MAPK6 MAPK4 MAP3K2 HEL-S-42 MAP2K6 PDPK1 PRKCA MAPK12 TRIB3 FOS EIF4E CRK RAPGEF1 GRB2 HEL-S-31 FAS PTEN ENPP1 MAP2K4 INSR MYO1C PFKM SHC3 JUN EGR1 EIF4EBP1 MAP4K1 PTPN1 PTPN11 IRS4 GSK3A GYS1 PRKAA2 PFKL PMC8165772__F7 Whole-genome resequencing provides insights into the population structure and domestication signatures of ducks in eastern China GRB2 SHE ENPP1 PMC7028855__F2 miR212 and Hedgehog pathway KIF7 SUFU PTCH1 SHH SMO GLI3 PMC10537781__F9 African swine fever virus I10L protein inhibits the NFKB signaling pathway by targeting IKKB TRAF4 MAP3K7IP1 TRADD IRAK1 TRAF6 TRAF2 MYD88 PMC8687399__F8 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy DKK1 APC LRP5 BCL2 NLK PMC4159616__F1 Bile Acids, Obesity, and the Metabolic Syndrome CYP8B1 GCA CYP7B1 CYP27A1 PMC8070467__F2 Metabolic link between diabetes and cancer EGF IGF1 MTOR PMC8687399__F6 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy APC LRP5 LRP6 NLK CTNNB1 PMC8687399__F7 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy BAX CASP9 CASP12 CASP3 BCL2 APAF1 TRAF2 PMC8038768__F8 Overview of this study SIPA1 HGF GRB2 PMC7933006__F2 Reduced Tdo2 expression leads to reduced Trp flux through the kynurenine pathway (KP) TPH1 TDO2 INMT HEL-S-90n KYNU SLC7A5 DDC PMC6908615__F8 Illustration on the possible underlying pharmacological mechanism of neurotrophic activity of SCH in cultured hippocampal neurons OXCT1 HNRNPH1 PREB STX1A PMC3687624__F1 Simplified view of the canonical Wnt signaling pathway (Modified from ref SOST APC GSK3B LRP5 LRP6 PMC6610485__F2 Mechanisms by which bacteria influence cancer development and progression STAT3 TIGIT CTNNB1 PMC11937519__F4 Schematic overview of the proposed BDNF-TrkB-FRS3 signaling pathway, its role in energy balance regulation, and its connection to the leptin-melanocortin pathway PCSK1 FRS3 LEPR POMC MC4R AgRP BDNF PMC9653759__F1 Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability BAX CGAS IRF3 PMC8633656__F1 Interleukin-17 family members in health and disease IL17RC SYK EBP CD93 IL17RB TRAF6 PMC6212405__F7 Distribution of the targets of Shenzhu Capsule on the compressed TNF signaling pathway IDE ITCH MLKL LIF CASP3 DAP HEL-S-11 TEF TRAF2 FOS PMC12115679__F4 Critical signaling pathways regulating TILs infiltration, proliferation, and anti-tumor response IFNG TIGIT FAS GPX4 FOXP3 IL8RB CXCL10 PMC5611503__F9 Signalling pathway of cytokine-cytokine receptor interaction signalling pathway TRO EGF LTA FAS LEP LTBR OSM EGFR EPO CCR3 GH1 MPL EPOR IF2D SP3 IL2 AMH IF2B1 KIT LTB ACTR2 TSLP IL24 CCR4 CXCR4 EDAR TNLG7C PMC6346075__F1 Transsulfuration pathway pcap PMC8700948__F1 Regulatory Effects and the Signaling Pathways of Natural Bioactive Compounds on Ferroptosis SLC3A2 TFRC GPX4 LPCAT3 FACL4 ADA PMC8217106__F4 Direct Targeting of Beta-Catenin in the Wnt Signaling Pathway: Current Progress and Perspectives APC TCF4 LEF1 PMC8217106__F1 Direct Targeting of Beta-Catenin in the Wnt Signaling Pathway: Current Progress and Perspectives BCL9 APC GSK3B LRP5 LRP6 PMC3376449__F1 HER2 signaling pathway STAT3 CR2 PTEN MTOR SRC CR1 PMC7450153__F1 CGAS-STING DNA sensing signaling pathway TBK1 IRF3 IL6 TNF PMC9318283__F9 Protective Effect of Eurotium cristatum Fermented Loose Dark Tea and Eurotium cristatum Particle on MAPK and PXR/AhR Signaling Pathways Induced by Electronic Cigarette Exposure in Mice AHR IL6 PMC7450153__F3 Protumor role of the cGAS-STING signaling pathway NFKB1 CCR2 MSC PMC7205036__F11 Scheme summarizing the mechanism of the protective effect of astragalin and CGA on E CGA CD14 IRAK1 IRAK2 TRAF6 IRAK4 IL1B MYD88 PMC3704221__F1 miRNA biogenesis pathway AGO4 DGCR8 AGO1 AGO2 CCR4 DROSHA PMC8782480__F4 IPA canonical pathway, “Interferon signalling” SOCS1 IFNG BAX PSMB8 IRF9 PIAS1 IRF1 GIP PMC12059070__F7 Gemcitabine-induced cellular responses CDC2 ATR RRM1 DTL RRM2 CCNA2 RPA1 PARP1 GMNN RB1 TK1 RPA3 CHEK1 SLBP POLD4 CCNB1 POLD2 PCLAF FBXO5 PMC5711269__F1 Reverse cholesterol transport pathway ABCG1 LDLR ABCA1 PMC3534848__F8 A proposed mechanism by which hyperaldosteronism decreases pulmonary endothelial eNOS activation and NO• generation in PAH CYP11B2 TET1 PMC4244643__F1 Biosynthesis of Isoprenoid building blocks IDI2 IDI1 MVK PMC4764764__F4 Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development TNFAIP6 EFNB2 HEL113 TGFB1 HEY2 F5 ERG EPCAM EDN1 F3 JAG2 KLF5 NOTCH3 PMC6214770__F7 Proposed signaling model of crosstalk between NIS and PTEN signaling pathway PTEN ARHA MTOR PMC12070570__F8 Schematic overviews of signaling pathways of enriched hypomethylated mRNAs in LMCI/Control LPL IDE BAD COMP APOC1 APOD CD36 SET TG ALK ABO PBR MCU APP NPB FADD ADA PMC7835216__F2 Emerging functions of branched ubiquitin chains UBR5 ITCH TXNIP APC PMC3785049__F3 Type I interferon induction is inhibited by paramyxovirus interferon-antagonist proteins at multiple stages TBK1 TLR3 IRF3 TRAF3 TRAF6 TRAF2 PMC3737169__F2 MTX cellular pathway AMPD1 DHFR ADK GGH TYMS HEL-S-70p MTR FPGS ADSL PMC9637033__F2 miRNAs: The Key Regulator of COVID-19 Disease TMPRSS2 DROSHA ACE2 PMC11752968__F2 Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases ATF4 XBP1 TRAF2 PMC4372648__F1 Three core signaling pathways altered in malignant gliomas MDM4 CDKN2A CDK6 CDKN2C CCND2 NF1 EGFR PDGFRA PTEN CDKN2B MDM2 CDK4 PMC7595309__F2 Dual-function quorum-sensing systems in bacterial pathogens and symbionts CASR SYP CP PMC5754225__F1 PI3K-AKT-mTOR signaling pathways in glioblastoma RHEB RPS6 TSC2 RICTOR TSC1 SGK1 PTEN MTOR IRS1 PMC3776238__F2 Wnt regulation of larval NMJ differentiation FZD2 DKFZp666G145 PMC6177712__F2 Schematic depiction of cannabinoid and exemplar mono‐, sesqui‐, and diterpenoid biosynthesis IPP C2 STS PMC7990354__F1 Molecular mechanisms of renal aging ROS1 APC GSK3B LRP5 LRP6 IL1B PMC2954189__F1 Simplified scheme of the double-edged role of Akt in tumor development CASP9 TSC2 BAD CDK2 MDM2 MTOR PMC11767460__F7 Association Analysis of the Genomic and Functional Characteristics of Halotolerant Glutamicibacter endophyticus J2-5-19 from the Rhizosphere of Suaeda salsa IMP3 SORD PROC TPP1 PMC7461309__F1 Pollen-induced activation of the innate immune system and Th2 polarization IL25 CCL22 TSLP CXCL13 TLR4 IL33 CXCR5 IRF4 TNF GATA3 CCL17 PMC4841025__F5 Insulin signaling pathway FAS CCK ARHG PYGB TRIP10 PTPRF PTPRT SOCS3 PCK1 CRK TSC2 CBL SOST CRB2 FBP2 LIPE PPARGC1A GCK PMC4841025__F6 Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice PPARG RARA NR1C1 SCD RXRA KERA NR1C2 PMC4841025__F7 Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice STAT3 LEP MTOR SOCS3 TNF PRKAA1 ACACB NR1C1 PRKCE PRKCA CHUK TRAF2 TEF PMC7059166__F2 Canonical Wnt/B‐catenin(WBC) signalling pathway APC GSK3B LRP5 LRP6 GPR49 LEF1 LGR6 PMC6483058__F4 Visualization of resulting networks from Min-cut on the pathway of AD GRIN2B BAD FAS CALML6 COX1 TNFRSF1A PPP3R1 CYCS GSK3B BACE1 PPP3CA MAPK3 ERN1 CDK5R1 ADAM17 APP GRIN1 PLCB3 APAF1 LPL IDE CASP9 CASP8 APOE HSD17B10 COX5A SNCA NAE1 TNF UQCRC1 CDK5 PAF1 RTN3 RTN4 HEL-S-162eP PSEN2 PLCB1 CASP3 CALM1 PLCB2 FADD PMC6483058__F5 Illustration for cut-edges and the CTGs in AD pathway from KEGG CASP9 FAS CYCS APOE GSK3B SNCA PSEN1 ERN1 CDK5R1 CDK5 HEL-S-162eP PSEN2 APP APAF1 FADD PMC7059166__F4 Cross talk dialogue between inflammatory and WBC‐signalling pathways in MPTP‐induced SVZ plasticity is lost with age HMOX1 GSK3B WNT1 CTNNB1 PMC5309231__F3 Downstream effects analysis enables prediction of the effect of gene expression changes in each treatment CASP9 BCL2L1 TGFA TNFRSF10B c-fgr CREM PRTN3 TNFSF10 TNF PRKCB PMC7186644__F1 Canonical Wnt/Beta-catenin signaling depends on the control of Beta-catenin degradation and translocation to the nucleus to activate target genes transcription DKK1 APC LRP5 LRP6 MYC CCND1 CTNNB1 PMC6256358__F1 Tankyrase function in cancer AMOT PTEN POLE PMC7226605__F3 Anti-cancer effects and cell death pathways regulated by cannabinoids and the classical cannabinoid receptors ATF4 MTOR EIF2A TRIB3 PMC8055291__F5 Illustration of TNF signaling pathway influenced by major putative targets of GBKC TRAF1 IL6 TRAF3 PTGS2 MMP9 CCL2 TRAF2 IL1B PMC8497507__F7 Schematic showing the roles of mGluR2/3, mGluR1 and DGK in controlling responses evoked by MF activation PLCB4 KCNJ6 DGKB DGKG GRM2 TRPC3 PMC1479816__F3 Pathways involved in mesenchymal cell proliferation and differentiation induced by G protein coupled receptors (GPCRs) ARHA RHO GRB2 MTOR PMC5987716__F2 SOD-dependent ROS signaling in mammalian cells TF HSF1 PRX PTEN SRC HEL-S-44 PMC6131212__F7 Activation mechanisms of the Hippo kinase signaling cascade LATS1 LATS2 SLMAP PMC4834478__F8 microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling STAT3 BAX STAT1 PMC4101832__F2 Processes and outcomes involving leptin, OB-R, Notch1, Notch4, IL-1R tI, JAG1, DLL4, VEGF, VEGFR2 (KDR), EGFR, AR and Ki67 (MKi67 gene) in the development of breast neoplasms MKI67 VEGFB VEGFC LEP DLL4 VEGFA PMC4701060__F1 Signal transduction pathway like mitogen-activated protein kinase/extracellular signal-regulated kinases signaling pathway STAT3 BAX JUN BAD APC TNF FOS CTNNB1 FYN CDK2 SMO MDM2 GRB2 SRC CDK4 FADD PMC2744676__F2 Diagram depicting proliferative and survival signaling pathways in cells BAX EGF BAD CDK6 PI3 EGFR MTOR CDK4 PMC7313395__F3 Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the Cell Cycle Pathway in Trypanosoma cruzi-infected myoblasts STAG2 RAD21 ATM SKP2 PMC3241824__F1 Operation of the mammalian Hippo pathway in mouse intestinal epithelium and human colon cancer YAP1 CTNNB1 PMC7313395__F2 Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the JAK/STAT Pathway in Trypanosoma cruzi-infected myoblasts STAT3 PIM1 JAK3 MTOR CSF3 PIAS2 CSF3R IL-21 CLCF1 STAT1 GFAP PIAS1 PIR FHL1 HEL-S-11 EP300 GRB2 JAK1 TYK2 PMC8632942__F6 Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease TES IFNGR1 IFNLR1 STAT2 IFIT1 IFIH1 IRF1 IRF7 STAT1 IFNGR2 IFNAR2 IFNAR1 ISG15 JAK1 OAS1 TYK2 PMC5362109__F2 Autoimmunity in vitiligo is driven by the IFN-Gamma-CXCL10 cytokine signaling pathway CXCL9 CXCR3 JAK1 CXCL10 PMC7272051__F3 Unveiling functional motions based on point mutations in biased signaling systems: A normal mode study on nerve growth factor bound to TrkA BAD FRS2 CR2 GRB2 IRS1 PMC11788965__F1 Simplified brassinosteroids (BR) biosynthesis and signalling pathways BIN2 UGDH PRX BAK1 CPD ABCB1 PMC11514642__F9 Abnormal expression of MECOM in uterine corpus endometrial carcinoma and its mechanistic involvement in regulating the Hippo signaling pathway and affecting cell cycle and apoptosis SMAD2 EVI1 FOXP3 CCND1 PMC4165418__F3 AKT's role in the NER pathway ERCC1 XPA PCNA PMC4165418__F4 AKT suppresses the HR pathway and activates the NHEJ pathway via many mechanisms RAD51 BRCA1 RNF8 ATM MDC1 PMC11276987__F3 Maladaptive UPR and endoplasmic reticulum (ER) stress-mediated inflammation VIT ATF4 EIF2A TNF XBP1 TRAF2 PMC3499080__F2 Alterations in the NRF2 canonical pathway in livers of mice treated with TMHF AOX1 HEL-S-107 PPIB KEAP1 GCLM HEL-S-94n VCP FKBP5 USP14 GPX2 TXN FTH1 CCT7 FTL EPHX1 GCLC CLPP HEL-75 UBB PMC11276987__F4 Unfolded protein response signaling with their regulating microRNAs ATF4 EIF2A XBP1 TRAF2 PMC8021562__F6 TOPORS-AS1 regulated by VDR, interacting with hnRNPA2B1, and inhibiting the Wnt/Beta-catenin signaling NR1i1 HNRNPA2B1 APC CTNNB1 PMC3137930__F8 Analysis of p53 target genes in melanocytes treated with Nutlin-3 for 18 h KLF7 PCNA NFKB2 CBX1 PTEN TIGAR FOXM1 KLF10 SCO2 MDM2 NOTCH1 GML BAX PIM1 PERP DTL ID3 CUL4A CDCA3 TK1 MCM10 NOC2L SSRP1 TAF6 CDK2 PMC11276987__F2 Schema of pathways producing and utilizing endoplasmic reticulum (ER)-derived H2O2 GPX8 HEL-S-97n NOX4 PMC9163972__F10 Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF‐KB Signaling Pathway CCR2 CCL7 CCL2 PMC9655277__F1 Immune Modulation by Myeloid-Derived Suppressor Cells in Diabetic Kidney Disease ROS1 PTH MTOR RAC1 PMC11276987__F7 Adiponectin signal transduction [118] APPL1 ADIPOR1 ADIPOR2 PTEN PMC5340150__F1 Autophagy in infection, inflammation, and immunity HMGB1 RIGI ATG16L1 NLRP3 ATG12 NOD2 AIM2 MTOR TRAF6 IL1B PMC11276987__F5 Cellular Senescence and Extracellular Vesicles in the Pathogenesis and Treatment of Obesity—A Narrative Review NLRP3 HSF1 IL6 MTOR SIRT1 PMC7237121__F1 CDK4/6 inhibitors and possible combined therapy with CDK4/6 inhibitors CDK6 MTOR CDK4 PMC11763662__F1 Various cell signaling cascades involved in breast cancer STAT3 AURKA EGF EGFR SMAD2 APC SMAD4 NUMB SMO MTOR CTNNB1 GLI3 PMC4281841__F2 Involvement of the IRE1Alpha-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases FAS NR1C1 CES1 DGAT2 PMC4281841__F3 Involvement of the IRE1Alpha-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases IRS1 PMC3478884__F1 Emerging role of nuclear architecture in DNA repair and genome maintenance ATR RAD50 ATRIP MRE11A RNF8 ATM PMC3711797__F4 Mathematical model of type I IFN signaling pathway SOCS1 STAT1 IRF1 PMC1304358__F3 Examples of extreme signaling pathways of the JAK-STAT signaling network IFNE STAT2 PMC7128030__F1 Bile acid synthesis CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC7867637__F2 High glucose on fibroblast activity and function SPARC CTGF IL1B PMC11763662__F6 Representative molecular targets in breast cancer, along with the corresponding immunotherapeutic and targeted treatment approach EGF CDK6 EGFR APC GRB2 SRC CDK4 PMC7785232__F6 GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection CD44 CD40 IFNG CD80 CD1C MERTK PMC11763662__F5 Molecular Insights on Signaling Cascades in Breast Cancer: A Comprehensive Review STAT3 TGFB1 HK2 CXCL1 SOX2 IL15RA CCL2 TGFBR2 PFKP CX3CL1 HLF SAMD3 CD163 PMC11763662__F3 Culmination of signaling pathways in the tumor stroma microenvironment involving cancer-associated fibroblasts (CAFs), adipocytes, and mast cells EGF CD36 CXCL1 CXCL16 FABP4 FAP CCL5 CCL2 CXCL3 FGF2 FABP5 PDGFRA CCL8 PMC9095358__F9 Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4/NFKB Signaling Pathway Affects Chondrocyte Pyroptosis GSDMD NLRP3 MYD88 PMC8802127__F7 Long non-coding RNA HNF1A-AS1 induces 5-FU resistance of gastric cancer through miR-30b-5p/EIF5A2 pathway GC EIF5A2 PMC9065418__F1 Association of TGFB Canonical Signaling-Related Core Genes With Aortic Aneurysms and Aortic Dissections SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 HP TGFBR1 PMC7061757__F8 Crosstalk between EGRF inhibition and TLR4 pathways in HNSCC TLR4 SRC MYD88 PMC7542117__F5 Core HIF-1 signaling pathway in THSWD against DR TF NOS2 HEL-S-133P EPO IGF1R VEGFA INS VHL TFRC IGF1 KEL TLR4 HEL-S-162eP FLT1 PMC3287012__F1 Signaling through CD44: hyaluronan binding to a receptor such as CD44 or RHAMM will cause a conformational change in the receptor LPA CD44 HGF ADAM17 PTEN ADAM10 CDC37 RHO TGFBR1 PMC2838843__F3 PTEN signaling pathway BAD PTEN PMC3844070__F1 The IFNG signaling pathway STAT1 IFNGR2 IFNGR1 PMC5964095__F10 Salvianolic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1A signaling pathway HEL-S-133P HK2 MTOR PMC6299648__F5 Oxidative status and leptin signalling pathway in human mammary epithelial cells STAT3 COX2 PMC11015925__F4 Circulating Levels of HOTAIR- lncRNA Are Associated with Disease Progression and Clinical Parameters in Type 2 Diabetes Patients MAPK1 STAT3 PIK3R1 PTEN MAPK9 IL6 NR1C1 PRKCE FOXO1 PDPK1 IKBKB NRAS PPARGC1A PMC6131212__F1 Activation mechanisms of the Hippo kinase signaling cascade LATS1 LATS2 NF2 PMC9925018__F8 KDM4D and Hippo signaling pathway in the regulation of cell cycle activities FOXM1 AURKB GC MYC YAP1 KDM4D PMC2913455__F7 E-selectin–mediated slow rolling CD44 SYK BTK c-fgr LYN PMC7546902__F4 Engineered biosynthetic pathway for geraniol in S MAF1 IPP ATF1 IDI1 PMC8481335__F2 Mitochondria in ferroptosis IREB2 CISD2 DGUOK SLC25A37 SLC25A28 LONP1 CGAS FXN FH ISCU GPX4 MFN1 MPC1 DHODH TFAM HMOX1 CISD1 PDK4 MFN2 POLG FES MITA GLS2 AIFM1 PMC6538180__F3 Transcriptional changes after herpes simplex virus type 1 infection in human trabecular meshwork cells DUSP5 ATF3 TGFB1 CCNL1 RHOB GADD45A PMC8481335__F1 Core mechanisms of ferroptosis TF SLC3A2 ACSL3 AIFM2 CD36 GPX4 LPCAT3 FACL4 HEL-S-89n SLC7A11 DHODH MPO POR ACSL1 CISD1 PLA2G6 NFE2L2 HEL110 LCN2 PMC5562070__F1 TGFB signaling induced apoptosis is modulated by the UPR cascade SMAD2 SMAD4 ATF4 EIF2A XBP1 PMC3430120__F2 Summary of pathways controlling muscle protein synthesis (MPS) and muscle protein breakdown (MPB) IGF1 MYF5 MTOR PMC4548225__F2 LGR4-Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 ZNRF3 IQGAP1 LRP6 CTNNB1 PMC8481335__F4 Endoplasmic reticulum in ferroptosis SLC3A2 CGAS ACSL3 STK11 KEAP1 CHAC1 GPX4 SCD MFN1 LPCAT3 FACL4 SLC7A11 MTOR MFN2 MITA ATF4 EIF2A PMC7647682__F3 Putative molecular mechanisms and signaling pathways that may regulate the endothelial-to-mesenchymal transition (EndoMT) process in systemic sclerosis SMAD2 SMAD4 CTNNB1 PMC9583547__F1 Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex GABRA2 SHBG GABRB2 PMC3313080__F2 Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate ATG12 GC ATF4 EIF2A UNK PMC12165590__F3 Applications of extracellular vesicles in osteoporosis HEL-S-133P CLEC11A CTHRC1 VEGFA PMC9583547__F3 Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex HRAS RAF1 EGFR MAP2K1 GRB2 SRC NR3C1 PMC8578048__F2 Long Non-Coding RNAs in Oral Submucous Fibrosis: Their Functional Mechanisms and Recent Research Progress COL1A1 E2F4 SMAD4 PTEN TRAF1 PDK2 SMURF2 PMC5394545__F5 High-Throughput Sequencing and Co-Expression Network Analysis of lncRNAs and mRNAs in Early Brain Injury Following Experimental Subarachnoid Haemorrhage TIRAP CTSK TLR9 MYO18B CPO IRF3 PLAC1 IL6 LAMC1 SHE IRAK4 RASIP1 LBP CD6 FADD PMC9547585__F7 The let-7f-5p regulates the PI3K/AKT/COX2 signaling pathway in forest musk deer lung fibroblast cell MUSK PIK3CA COX2 PMC6597188__F1 TNF-driven cell death in donor organ as a barrier to immunological tolerance RIPK3 TRADD MLKL TNF CYLD TRAF2 FADD PMC5011664__F1 Canonical wingless/int-1signaling pathway BTRC APC GSK3B LRP5 LRP6 CSNK1A1 CTNNB1 PMC4039567__F8 De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways TLR4 CXCL1 CXCL2 CS CCL2 MYD88 PMC5011664__F2 Non-canonical wingless/int-1 signaling pathway TSC2 FYN ROR2 RYK ATF2 ARHA MTOR SRC PMC4644789__F1 Interplay of TrkB and GR signaling pathways in the CNS CRH GC CRTC2 GCGR SHE BDNF PMC5836295__F1 Regulation of IL-33/ST2 pathway by sST2, IL-33 neutralizing antibodies, and GSK3Beta-regulated ubiquitin-proteasome system GSK3B IL33 FBXL19 PMC7232267__F5 Micro ribonucleic acid (miRNA) cross‐talk between miR 29 and miR let‐7 in the anti‐endothelial mesenchymal transition action of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline (AcSDKP) FGFR1 DPP4 TGFBR1 PMC8047194__F1 Hippo signaling pathways in Drosophila and mammals LATS1 FAT4 CDK7 HEL70 NF2 VGLL4 FAT2 FAT3 PMC7232267__F4 Fibroblast growth factor receptor 1 (FGFR1)–B klotho complex plays roles in endothelial homeostasis FGF8A FGF21 FGFR1 PMC4975621__F5 CAR targeted miRNA and mRNA in liver cancer STAT3 OGT CYP2A6 ABCC1 SERPING1 ADIPOR2 FASN HEL-S-78p MBTPS1 INSIG1 LIPA NR2F6 NR1C1 IGF1 ABCC3 ABCC2 APOA5 PMC8188209__F11 Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles FH C1S C1R VTN CR1 PMC9100923__F1 Prenatal Choline Supplementation Alters One Carbon Metabolites in a Rat Model of Periconceptional Alcohol Exposure PEMT MTRR HEL-S-61p MTR PMC3245622__F1 PI3K/Akt signaling pathway is involved in several human cancers BAD PTEN MTOR PMC9601721__F3 Whole-Exome Sequencing Reveals Pathogenic SIRT1 Variant in Brain Arteriovenous Malformation: A Case Report STAT3 KLF2 BNIP3 PTEN INS SKP2 ATG12 FAR1 INSR CDK2 ATM NLK MDM2 PMC6902869__F1 Tumor-targeting bacteria engineered to fight cancer IFNG TLR4 CD14 TLR5 IL1B PMC9553029__F3 NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain PANX1 TG TRPV1 HP PMC7461546__F5 NME protein-histidine kinase functions ACLY HEL-S-132P TRPV5 SUCLG1 NME2 EGFR KSR1 LHPP PMC11194209__F1 Major abnormal signaling pathways in TNBC EGF EGFR APC FZD7 LRP5 LRP6 PTEN GRB2 MTOR SHE NOTCH1 PMC4748524__F1 TLR signaling pathway genes TIRAP TLR9 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 TLR7 PMC7272661__F2 Graphic illustration of molecular autophagic pathway ATG101 ATG10 ATG3 FYCO1 ATG12 ULK1 UVRAG AMBRA1 ATG14 MTOR ATG5 PMC3872270__F2 Many ways to inactivate the p53 pathway in cancer ATM PTEN MDM2 PMC9284706__F2 Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death PANX1 CD80 FAS HIF1A CTLA4 PMC7033608__F3 Possible mechanism of Wilms tumor 1 antisense RNA (WT1-AS) functioning WT1 FOXN2 PMC7602874__F2 Schematic diagram of the role of the cGAS-STING pathway in cancer immunity TH SLC19A1 PMC7602874__F1 Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signalling pathway TBK1 CGAS IRF3 ENPP1 PMC3998523__F1 Sphingolipid pathway and subcellular localization of sphingolipid enzymes SMS tmp_locus_29 SKI PMC7876374__F2 Effect of EGCG on miRNA and Ca2+signaling in T cells STIM2 ORAI1 ELL PTEN MTOR PMC4438218__F1 Proposed model for the regulatory role of methenyl-dH4MPT in methylotrophic metabolism in M HPR HP GCK PMC9118050__F2 Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities CXCL12 TP53INP1 TXNIP SMAD2 CXCL1 HIF1A CXCL2 FAP CTNNB1 LBR CD44 COX2 WNT7A CXCR4 CYLD PMC3241001__F1 Pharmacologic Induction of CD8+ T Cell Memory: Better Living Through Chemistry RHEB TSC2 TSC1 APC GSK3B LRP5 LRP6 PTEN MTOR CTNNB1 EIF4E PMC9843445__F3 Major roles of the circadian clock in cancer ALDH3A1 MTOR PMC5213309__F5 Soluble tumor-derived signals change the phenotype of the tumor-associated macrophage, by induction of the mTOR pathway and glycolysis, and epigenetic changes MTOR PMC4047762__F6 ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway SMAD1 DKFZp781O1323 HEY2 DLL4 SMAD4 ID1 RBPJ PMC4248790__F4 Piwi proteins and piRNAs step onto the systems biology stage DNMT3B TDRD1 DNMT3L HIG-1 MOV10L1 FKBP6 PMC6726984__F2 SnoRD126 activates the PI3K-AKT signaling pathway through FGFR2 and snoRD50A/B and affects the MAPK signaling cascades PDK2 MYC FGFR2 PMC6329944__F1 Three phases of tooth eruption, preeruptive, intraosseous, and supraosseous, require signaling in the PTHrP/PTH1R pathway CSF1 PTH1R PMC5751231__F7 Regulation of miRNA expression in response to maternal disease and stress CCND2 E2F2 ADRA1A MYH7 FOS PRKG1 PMC7992277__F10 Na+ controls hypoxic signalling by the mitochondrial respiratory chain CAD MCU HEL-S-11 NACA PMC9580515__F5 Effect of micro/nano-sheet array structures on the osteo-immunomodulation of macrophages STAT3 MTOR CD47 PMC7356105__F2 Illustration depicts the localization of the gene products by cellular compartmentalization and indicates the downregulated expression of NF-kappaB signaling pathway as an effect of vitamin E formulation treatment on heat killed C EGF NGF LTA TGFA TIRAP TRAF2 PMC7728999__F4 LncRNA XLOC_221242 regulates the expression of DNER, which is the key factor of Notch signal pathway CDH2 SKP1 DNER RBPJ CTNNB1 PMC3604104__F5 Gene Expression Networks Underlying Ovarian Development in Wild Largemouth Bass (Micropterus salmoides) PDPK1 GSK3B CTNNB1 PMC3243113__F10 MULTIPLE WAYS TO DIE: DELINEATION OF THE UNFOLDED PROTEIN RESPONSE AND APOPTOSIS INDUCED BY SURFACTANT PROTEIN C BRICHOS MUTANTS ATF4 TRAF2 PMC9013399__F1 Significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease NNMT NAPRT HEL-S-90n NAMPT PMC4935227__F2 WWOX regulates multiple signaling pathways ERBB4 WWOX SHH SMO DVL2 SRC TNF RUNX2 PMC8360401__F2 Ischemic postconditioning for stroke treatment: current experimental advances and future directions BAD TLR4 BCL2 MTOR IRAK4 IL1B CTNNB1 PMC4935227__F3 The potential role of WWOX in anticancer drug-induced cancer cell apoptosis WWOX MTOR ATG5 PMC8036776__F1 NF-kB pathway targeted by GSH COX2 IL6 IL1B PMC3155407__F1 Murine model of the multiple actions to suppress immune surveillance of exosomes released from neoplastic cells JAK3 CD14 FOXP3 PMC4159787__F3 The relationship between RAGE and neurite outgrowth after spinal cord injury CDC42 HMGB1 S100B PMC4724957__F3 Metabolic pathway map of Parachlorella kessleri ATG14 ACD PMC8708558__F2 Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression SPON2 EMILIN1 FHL3 PLOD1 HEL113 HAPLN3 HHIPL1 PDLIM7 ADAMTS7 PDLIM2 C1R ZYX BMP1 MFGE8 COL18A1 TOR4A NOTCH1 PMC2533793__F10 Model for negative regulation of Wnt signaling pathway by corepressors SMRT and NCoR HDAC3 TCF4 CTNNB1 PMC5926502__F4 BIOGF1K, a compound K-rich fraction of ginseng, plays an antiinflammatory role by targeting an activator protein-1 signaling pathway in RAW264.7 macrophage-like cells TK1 TLR4 AK1 CD14 ATF2 MYD88 PMC4013446__F2 Functional significance of differentially expressed miRNAs—miRNA-512-5p, 190a and 200b-3p (Ingenuity pathway analysis) ACVR2A ROCK2 RECK LEMD3 RPS6KA2 PHF6 BRAF TAF4 PAG1 HEL70 SLC23A2 RAPGEF2 RAPGEF1 MAPK7 PMC7457075__F7 Possible mechanism of anti-inflammatory effect of OEA on colitis NR1C1 TRAF2 IL1B PMC4629442__F1 EGFR and its signal pathway STAT3 EGF BAD TGFA EGFR BCL2 PTEN GRB2 MTOR SRC PMC3548163__F2 Modes of action of environmental risk factors for autism at excitatory synapses in the CNS IGF1 GPR39 IGF1R PMC5964985__F2 Atrial fibrillation genes in calcium signaling and ECM–receptor interaction RYR2 SYK PTGER3 PLCB4 HSPG2 ITGA4 ERBB4 CD36 EGFR CHRM3 HTR2A ITGB3 PRKCB RYR3 ITGB6 AGRN ITGA1 PLCG2 PLCB1 PRKCA TTN PTGFR SDC2 LAMA3 PMC10933535__F1 Metabolic reprogramming and signalling cross-talks in tumour–immune interaction: a system-level exploration SOCS1 ZAP70 TH EGF CD80 CCL22 FAS TRADD APC PTEN TNF IFNG TSC2 ERBB2 CCR4 FOXP3 TRAF2 CCL17 PMC6321258__F1 Interaction between metabolism and histone acetylation and DNA/histone methylation ACLY ACSS2 PDC PMC2760069__F1 Brothers and Sisters: Molecular insights into arterial-venous heterogeneity EPHB4 HEY2 FOXC2 FLT4 NRP1 FOXC1 NRP2 SOX18 SOX7 NOTCH1 PMC7324687__F2 Dopamine interaction with adenosine and NMDA signaling JUN PER2 PER1 PMC4650770__F1 Biosynthetic pathways of histo–blood group antigens GAL FUT1 FUT4 FUT6 FUT9 FUT2 FUT5 FUT3 H1-2 PMC7322524__F1 Cell death pathways triggered by DNA sensors TBK1 CGAS GSDMD AIM2 IRF3 IL1B PMC7322524__F2 Cell death pathways triggered by RNA sensors RIPK3 BAX TBK1 ZBP1 MAVS TLR3 MLKL KL RIPK1 IRF3 FADD PMC8972192__F2 Exploration of Novel Pathways Underlying Irreversible Electroporation Induced Anti-Tumor Immunity in Pancreatic Cancer IFNG TRAF4 STAT1 TLR9 IRAK1 JAK1 TRAF6 MYD88 PMC5897459__F2 Biosynthetic pathway of thylakoid glycerolipids from phosphatidic acid (PA) in Arabidopsis thaliana PGP CDS2 CDS1 PMC8744307__F2 Inflammasomes in vascular cognitive impairment NLRC4 NLRP1 IL10 GSDMD NLRP3 AIM2 PMC5758348__F2 Illustration of the cellular and molecular targets of total and individual Panax notoginseng saponins (PNS) on neural cells destroyed by Alzheimer's disease RB1 ChAT REL PMC6830763__F1 Brief description of the interaction of a CD4+ T cell with B cells CD40 IFNG CD80 UNG PMC8292787__F1 Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy TSLP BCR IL33 IL5RA PC PMC8700074__F1 Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases KLF6 AHR AHRR REL CYP1A1 PMC3782218__F1 Role of the proteins and mediators involved in iron homeostasis and impact of hereditary hemochromatosis protein mutations in chronic kidney disease STAT3 BMP6 TFR2 EPO HAMP HFE IL6R HFE2 PMC7356105__F3 TNF pathway inhibition in HGF in response to C MAPKAPK2 A2M TNF TRAF2 UNK PMC10487821__F9 Activation of the Wnt/Beta-catenin signaling pathway via lithium released from the IPN-Li hydrogel APC GSK3B LRP5 LRP6 CTNNB1 PMC6818723__F14 Hypothetical signaling network integrating top genes identified through Rasch analysis BGLAP RPTOR FXN APOE PRNP NTM MTOR ARC PLXNC1 AEN CASR HDAC3 FYN ITGB1 MDM2 PMC2674702__F1 Metabolism of extracellular and intracellular bioactive lipids LPA C2 PMC5364998__F2 Paradoxical Role of High Mobility Group Box 1 in Glioma: A Suppressor or a Promoter? HMGB1 TLR9 RAC1 PMC8285047__F2 Nitric oxide in orthodontic tooth movement (Review) COX2 SRC CTNNB1 PMC7906391__F5 Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease APP PMC1571327__F6 FGF, Wnt and Tbx3 in epithelial–mesenchymal interactions regulating mammary gland initiation FGFR1 TBX3 FGF10 LEF1 PMC6295738__F4 The enzymes of bile acid synthesis BAAT AMACR PMC3612991__F2 Harmonies Played by TGFB in Stem Cell Biology NOG LIF SOX2 GSK3B SMAD4 NODAL CTNNB1 PMC2776288__F2 Crosstalk between ionizing radiation-induced apoptosis and NFKB pathway BAX ATM TRAF2 PMC2776288__F3 Crosstalk between apoptosis and NFKB signaling by IAP-antagonist MAP3K7IP1 TRAF2 PMC3362995__F5 The WNT10b and galanin-mediated signaling pathways linked to adipogenesis SFRP5 LPL DKK2 PMC2662368__F2 T cell differentiation proceeds along distinct pathways following antigen presentation by DCs IFNG STAT3 IL10 AHR STAT4 FOXP3 GATA3 PMC12133554__F2 Molecular mechanisms of LGR4 in tumor bone metastasis DKK1 LRP5 RNASEK CTNNB1 PMC2704819__F2 Catabolic pathways encoded by the T POR PMC12133554__F1 Molecular mechanisms of LGR4 in bone metabolism BMP2 LRP5 NFATC1 ATF4 CTNNB1 RSPO1 PMC8755460__F3 K63 ubiquitination in immune signaling TBK1 CGAS MAVS IRF3 IRF7 TRAF3 TRAF6 SHARPIN NLRP12 NLRX1 NLRP3 BCR NLRC3 RIPK1 FOXP3 TRAF2 PMC9452849__F13 Hope for bone regeneration: The versatility of iron oxide nanoparticles OMD DKK1 PDGFRA FGFR1 GRB2 RUNX2 CTNNB1 PMC4082789__F1 Exploiting sulphur-carrier proteins from primary metabolism for 2-thiosugar biosynthesis C6 HEL-S-62p C2 PMC7554980__F2 mRNA in vitro transcription and innate immunity activation RIGI MAVS TLR3 TLR8 RNASEL IRF7 TLR7 EIF2A MYD88 PMC3670240__F1 Ubiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells STAT3 LIF GSK3B TRIM8 TRIM6 TBX3 GRB2 MYC PMC8927697__F4 Inflammation and Cancer: From the Development of Personalized Indicators to Novel Therapeutic Strategies HMGB1 COX1 COX2 PMC2993794__F1 Stimuli and factors involved in yeast chronological aging HTRA2 TH PMC7072724__F8 PP2A regulation by S67/S62-phosphorylated ENSA/ARPP19 in human platelets and the impact of PKA/PKG on it ENSA ARPP19 VASP PMC8832032__F4 Mitochondrial Quality Control: A Pathophysiological Mechanism and Therapeutic Target for Stroke ATG10 TBK1 PINK1 ATG12 PGAM5 BNIP3 ATG5 PMC3185810__F2 Alteration of the IFN-I signaling pathway by HTLV-1 STAT2 IFNAR2 IFNAR1 JAK1 TYK2 PMC6330656__F1 Targeting ERBB Activation Mediated by CD74-NRG1 ERBB3 NRG1 CD74 ERBB2 PMC7823493__F2 Synovial membrane and bone interactions in rheumatoid arthritis LPA IFNG TNF PMC9158144__F7 Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer MT2A LATS2 PMC3185810__F1 Interplay between HTLV-1 and the type-I interferon (IFN-I) induction pathway TLR3 TLR9 TLR8 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC6361815__F1 Different types of GSLs UGCG B3GNT5 B4GALNT1 A3GALT2 A4GALT PMC10216109__F2 Melatonin antioxidant properties and tryptophan metabolic pathway CAND2 PRX ASMT PMC4043215__F1 Hypoxia-Activated Pathways Leading to Cancer Stem Cell Maintenance CD24 POU5F1 PMC6181033__F7 Proposed model for the role of ZmbZIP4 in maize root development and stress response ARF3 RAB18 PMC2695822__F9 Display of genes with high expression in IVF embryos ELL PRNP NGDN PMC10243716__F2 Ferroptosis as a vulnerability in cancer TFRC GPX4 EGFR FACL4 HILPDA NF2 ELOVL5 HEL-S-26 NOX4 DHODH VHL PMC4890337__F10 MWCNTg promote the EMT through the TGF-Beta-mediated Akt/GSK-3B/SNAIL-1 pathway TGFA CTNNB1 PMC8425214__F1 Regulatory networks of the Hippo signaling pathway in cancer development LATS1 LATS2 PMC5015648__F2 AB-crystallin negatively regulates multiple steps in the intrinsic (mitochondrial) apoptotic pathway BAX CASP9 CASP3 PMC2773630__F6 Molecular interactions during pheromone induced cell polarization CDC42 CDC2 FAR1 PMC8425214__F4 Regulatory networks of the Hippo signaling pathway in cancer development LATS1 CA3 LATS2 RHO PMC6206039__F7 Scheme summarizing the inhibition of cisplatin-induced nephrotoxicity by maltol via the down-regulation of AMPK through PI3K/Akt pathway BAX CASP9 TRADD CASP3 MTOR TNF TRAF2 FADD PMC8425214__F2 Regulatory networks of the Hippo signaling pathway in cancer development LATS1 SIAH1 SIAH2 AMOT ATF4 RHO USP9X PMC5597640__F9 Model for replication stress and its aftermath in the absence of BRCA2 RAD51 MRE11A BRCA2 PMC8425214__F3 Regulatory networks of the Hippo signaling pathway in cancer development LATS1 TBK1 MAVS SRC RUNX2 PMC9393183__F2 Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progression MASP1 HEL-S-62p C2 C1S PMC9393183__F3 Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progression MASP1 PLG ACE2 PMC11265800__F6 Signaling pathways in melanoma cells and tissue MMP2 CSPG4 PMC2887297__F1 Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease ELF2 ATF4 EIF2A PMC8584052__F2 P5C as an Interface of Proline Interconvertible Amino Acids and Its Role in Regulation of Cell Survival and Apoptosis MYC PRODH PYCR2 PMC9452720__F1 How zoledronic acid improves osteoporosis by acting on osteoclasts CSA2 CTSK TRAF6 PMC6349126__F1 Schematic outline of PC metabolism in yeast PLB1 GPC1 PC GDE1 PMC5701083__F2 Signaling pathways involving PFKFB3 EGF F2 APC PMC4209037__F3 Gene association network (GAN) 3 in lung ECSIT DAZAP2 SKIL FUCA1 EEF1G SMURF2 PPL PMC5701083__F3 Roles of PFKFB3 in different cancer cells SP1 PMC2814429__F2 Regulation of autophagy and apoptosis ATG10 ATG3 ATG12 HEL-S-62p MTOR ATG5 FADD PMC9356572__F2 Unique mutations in SARS-CoV-2 Omicron subvariants' non-spike proteins: Potential impacts on viral pathogenesis and host immune evasion MAVS TLR3 STAT2 WAS IRF3 IRF7 TRAF3 IMPACT PMC10881233__F2 Action of cryoablation combined with immune checkpoint blockers CD80 APC PMC6706170__F1 AvB5 integrin/FAK-mediated phagocytic pathway in TM-1 cells GULP1 ARHG TIAM1 CD36 SIRPA HEL-S-28 CD47 RAC1 DOCK1 PMC8514698__F2 Optimization of BCG Therapy Targeting Neutrophil Extracellular Traps, Autophagy, and miRNAs in Bladder Cancer: Implications for Personalized Medicine LAMP2 ATG10 ATG3 ATG12 ATG14 ATG5 PMC7641543__F1 EMT transcription factors by Wnt/GSK3B/Beta-catenin/Snail and PI3K/AKT/GSK3B/Snail signaling EGF EGFR APC GSK3B IRS1 CTNNB1 PMC10743660__F3 Nexus of Inflammation-Induced Epithelial-Mesenchymal Transition and Lung Cancer Progression: A Roadmap to Pentacyclic Triterpenoid-Based Therapies HMGB1 CXCL12 HGF SMAD2 ANXA2 APC SMAD4 PTEN IGF1R CTNNB1 MYD88 IGF1 TLR4 SRC CXCR4 PMC11720236__F2 Mechanisms of exercise modulation of pulmonary fibrosis TLR4 CXCL5 SMAD2 LRP6 IL8RB CTNNB1 PMC8168423__F9 Oral intake of Lactobacillus plantarum L‐14 extract alleviates TLR2‐ and AMPK‐mediated obesity‐associated disorders in high‐fat‐diet‐induced obese C57BL/6J mice FAS TIRAP FABP4 MYD88 PMC10743660__F4 Immune component of inflammation-induced EMT in lung cancer STAT3 SMAD2 CCR2 SMAD4 CCL2 IL6R PMC11720236__F3 Exercise modulation of renal fibrosis NR1C1 NOX4 SIRT1 PMC10743660__F6 Inhibition of inflammation-induced EMT by PTs CDH2 STAT3 EGF HMGB1 TIMP1 SYNPO EGFR SMAD2 APC LRP5 SMAD4 LRP6 MTOR RHO TRAF6 SKP2 CTNNB1 MYD88 RBX1 SMURF1 TLR4 SKP1 PMC11720236__F1 Pathogenesis of fibrosis: After tissue injury, immune cells (mainly macrophages) are activated and release cytokines (e SMAD2 SMAD4 CTNNB1 PMC10743660__F1 Key molecular events of EMT CDH2 CTNNB1 PMC11240630__F1 Pathways associated with the signaling of BCSCs APC GSK3B SMO MTOR PMC11720236__F4 Exercise modulation of myocardial fibrosis CHI3L1 STAT3 SIRT3 NRG1 LOXL2 FSTL1 FGF21 SMAD2 FOS SIRT1 FGF23 PMC11720236__F5 Antifibrotic mechanisms of exercise: Exercise exerts its anti-fibrotic effects by directly or indirectly (secreting exerkines or targeting microRNAs) affecting multiple signaling pathways associated with fibrogenesis CHI3L1 NR1C1 FSTL1 FGF21 LRP6 SIRT1 CTNNB1 PMC9366252__F3 Progress of tumor-associated macrophages in the epithelial-mesenchymal transition of tumor CDH2 JUN SMAD2 APC TGFBR3 VTN SMAD4 MTOR CTNNB1 TGFBR1 PMC10743660__F7 Inhibition of stemness by PTs STAT3 EGF RARA RBX1 HEL-S-53e EGFR APC SOX2 SKP1 SKP2 CTNNB1 PMC3318742__F8 Model of how RACK1 mediates activation of SHH/GLI signaling in NSCLC Cells SHH SMO PMC5605425__F1 Linking long non-coding RNA to control bile acid signaling and cholestatic liver fibrosis EPCAM S1PR2 CYP7A1 BCL2 PMC6500875__F2 Annexin A1 in inflammation FPR2 TNF PMC6500875__F3 Mechanisms of Annexin A1 in tumorigenesis SMAD2 SMAD4 PMC5884027__F2 NRF2- and SIRT1-signaling pathways targeted by antioxidant compounds IGF1 FOXO3A GSK3B PTEN SIRT1 PMC6443714__F1 The cytoplasmic destruction complex constitutively targets Beta-catenin for degradation LRP5 MSC CTNNB1 PMC5872689__F6 Suggested mechanism of pinitol-induced effects on the insulin secretion pathway IL10 CAD C4A PMC5884027__F1 Schematics of the metabolic pathways and their cellular localization affected in branched-chain organic acidurias and homocystinuria disorders mentioned in this work TCN2 PCCA DBT PCCB MTRR MMADHC CD320 CBL BCKDK CBLC PC DLD ABCD4 PMC1820632__F1 Cytokine-Effects on Glucocorticoid Receptor Function: Relevance to Glucocorticoid Resistance and the Pathophysiology and Treatment of Major Depression STAT3 STAT1 JAK1 TYK2 PMC5827745__F2 BCR‐ABL pathway BCR FOXO3A SMAD2 SMAD4 IHH SMO PTEN GRB2 MTOR CTNNB1 PMC8112168__F1 Multiple catalytic functions of IPMK in inositol biosynthesis pathway IPMK PTEN PPIP5K1 IP6K1 PMC7565564__F2 Examples of molecular mechanisms underlying the effects of uremic toxins on various cells, with focus on the aryl hydrocarbon receptor signaling (AHR) pathway TF AHR SRC PMC5187886__F2 Possible mechanisms of estrogen or EED action JUN SP1 PTEN NRF1 FOS PMC7773746__F1 Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway BAX BCL2 PMC6678879__F8 miR526b and miR655 overexpressing cells showing significant down regulation of tumour suppressor gene phosphatase and tensin homolog (PTEN) mRNA expression COX2 PTEN PMC5312548__F9 The role of NAD+ in the macrophage metabolic switch NAMPT HIF1A SIRT1 PMC6619438__F2 Innate immune recognition of Chlamydia TLR1 CGAS EPHA2 TLR3 TLR4 CD14 NOD2 IRF3 NOD1 IRAK4 MYD88 PMC3127207__F4 GenMAPP Diagram of Cell Cycle Pathway Genes Regulated by Luteolin in E2-Treated MCF-7 Cells CCND3 PCNA TFDP1 CDC6 GSK3B CCNA2 PLK1 SKP2 CCNH CCNB3 RB1 RBL1 CCNE2 CDK6 CCNE1 CCND2 WEE1 CDK2 CCNB1 CDC25B CDK4 PMC7076373__F1 CDC1 DC development CLEC4C CLEC9A XCR1 ID2 PDC BATF3 IRF8 PMC3127207__F2 Luteolin Effects on Estrogen Signaling Pathway (ESP) Genes DDX5 CRAT PGR IGFBP1 NRP1 HDAC3 PCK2 NCOR2 PELP1 CARM1 NCOR1 GRIP1 GRB2 TBP SRC SMARCA4 PMC6615902__F4 WNT signaling and regionalization of the GI tract epithelium BARX1 CDX2 DKK1 SOX2 SI IHH TCF4 CTNNB1 PMC12043837__F4 Regulatory role of lactylation in glioma pathology KLF15 ALDH1A3 HEL-S-133P PMC8582492__F1 Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A ZAP70 SYK JUN PTPRO BCR TCL1A PNPT1 ATM LYN FOS PMC6912360__F8 Mechanism capable of expressing or inhibiting an effect of Temozolomide (TMZ) MSH6 MSH2 PMS2 MGMT PMC5941588__F9 Comparison of networks affected by FA or O3 exposure in females at different stages of the estrous cycle AVEN CCNJ TNFAIP2 TMCC1 KIN MYC PMC10388730__F6 Influence of cold-stimulated adipocyte supernatant on the expression of adhesion-related molecules in Schwann cell line MAX ECSIT EGF JUND FAS RAF1 MAK CRKL CD14 TNF TRAF6 FLNA COIL HP NLK BDNF TRAF2 PMC4978108__F2 Apoptosis in pancreatic Beta-islet cells in Type 2 diabetes BAD FAS PMC7738964__F3 Peroxisome proliferator-activated receptor (PPAR) signaling pathway in the MetaCore analysis RXRA ACOX3 CPT2 CPT1A ACADM PMC7937674__F8 Schematic overview for the positive feedback loop between OTUD5 and mTOR signaling pathway OTUD5 MTOR DEPTOR PMC6605495__F1 Nutrient flux through the HBP modulates protein O-GlcNAcylation OGA OGT PMC8441765__F8 Schematic illustration of the proposed mechanisms for paclitaxel-induced growth inhibition in PC9 cells EGF ATR CCNE1 H2AX EGFR CDK2 BCL2 MTOR FADD PMC6605495__F2 Helper T cell differentiation and HBP STAT3 STAT1 APC FOXP3 GATA3 PMC5984665__F1 MicroRNA Regulation of K-Ras in Pancreatic Cancer and Opportunities for Therapeutic Intervention SPRED1 NF1 EGFR PTEN GRB2 SPRY1 PMC9136457__F1 When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response PLCB1 IPMK PTEN INPP5E PMC7216198__F8 Regulatory role of the IPs in immune surveillance in PB CD34+ Cells of PMF JAK2V617F mutated patients IFNG STAT1 IRF1 ARG1 TAP1 B2M TAP2 PSME2 HLA-A CD34 PMC2797409__F3 Reconstructed CCM of S POR HEL-S-162eP CS GK5 PMC4347221__F1 Shifting ecologies of malignant and nonmalignant cells following BRAF inhibition SYK RAF1 BCR BRAF NRAS PMC8036963__F3 DNA damage response (DDR) pathway involves sensor, transducer, mediator/amplifier, and effector proteins, which act following the induction of a DNA lesion or replication stress ATR ATRIP H2AX ATM PMC4867368__F7 The mechanistically diverse PF03099 lipoyl metabolism enzymes LPA LIPA LIPI LIPM PMC2579334__F3 Dysregulation of Mitochondrial Dynamics and the Muscle Transcriptome in ICU Patients Suffering from Sepsis Induced Multiple Organ Failure CRK BAD PDE3B CRAT GRB10 FYN VAMP2 PTEN GRB2 EIF4E PMC4637204__F4 Systemic Problems: A perspective on stem cell aging and rejuvenation STAT3 SMAD1 TGFBI MTOR PMC4855646__F9 Signaling pathways of TRIAD HNRNPAB HNRNPA2B1 PLK1 HTT PMC8236053__F2 Comparative Review of the Cell Biology, Biochemistry, and Genetics of Lactose Synthesis GAL B4GALT1 AQP3 LYZG DAP PMC6927352__F5 Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH LPL VWF ARHH VASP THY1 CD36 ARHA CHAD RAC1 CD47 CD44 TEC ITGAM CD9 PMC8616064__F2 Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms HGF CCL2 LAG3 PMC5131002__F2 YAP mediated gene expression in liver fibrosis LATS1 MOB2 ANKRD1 AMOT RHO PMC8431187__F2 Myeloma–Bone Interaction: A Vicious Cycle via TAK1–PIM2 Signaling STAT3 PIM2 VCAM1 TNF PMC4336165__F2 Growing recognition of the role for rare missense substitutions in breast cancer susceptibility BARD1 BRIP1 RAD50 RAD51 MRE11A BRCA1 BRCA2 CHEK2 ATM PALB2 PMC7699596__F3 Key autophagy pathway and its regulators (natural compounds) for treating diverse cancers TSC2 TSC1 RAF1 ULK1 MTOR PMC6636509__F8 Proposed model for the impact of targeted therapeutics, vemurafenib (PLX) and trametinib (TRA) on differentiated/pigmented phenotype of melanoma cells MC1R DCT PMC5618570__F2 Glycans and insulin/IGF system in cancer: an integrated mechanism OGT IGF1 MGAT3 IGFBP1 HIF1A IGF1R PMC6027367__F1 Unfolded protein response and NFKB signaling ATF3 ATF4 EIF2A TNF TRAF2 PMC5618570__F1 Insulin/insulin-like growth factor (IGF) system IGF2R IGF1 IGF1R IGF2 PMC4412144__F3 IPA Network JMJD6 WNK1 MCAM PLEKHF2 HOMER1 IMP3 SGK1 PITPNB TNFSF13 BNIPL CREM TSC22D3 TFRC LITAF ERRFI1 DDIT3 CREB1 PMC9388724__F5 Neuronal ferroptosis after intracerebral hemorrhage BAX KLF2 GPX4 USP11 SLC7A11 PMC4245781__F1 Signaling pathways of TRKA activation by NGF NGF FOXL2 GRB2 IRS1 PMC10705282__F4 In PTC, glycolysis is crucial for tumor growth STAT3 PMC6194107__F2 Origins of centromeric breaks DNMT3B MSH4 MSH6 ATR RAD51 MSH2 MSH3 SMC5 PTEN RIF1 BLM TOP2A PMC11375557__F2 Transcription Factors and Signaling Pathways in the Process of EMT KLF4 STAT3 EGF MMP14 SP1 KIF20A BTF3 OVOL2 ARL4C S100P EIF4E ITGB6 FOXM1 WT1 SOX9 FOXC2 ERBB2 CEACAM6 GATA6 ZEB2 MUC4 STC1 EIF5A2 PMC3757712__F3 Crosstalk between the Nrf2 and NFKB pathways HDAC3 KEAP1 MAF PMC10705282__F2 Exogenous pathway is a process for delivering triglycerides to peripheral tissues using chylomicrons and VLDLs LPL APOE LDLR PMC2758290__F1 The SIAE (sialic acid acetylesterase)-Siglec pathway for inhibitory signaling BCR CD22 LYN SIAE PMC3678537__F2 Wound Healing in Development APC GSK3B ARHA RAC1 CTNNB1 PMC3622313__F1 Regulation of HDL homeostasis by miRNAs ATP8B1 TG ABCG1 ABCB11 LDLR ABCA1 PMC4052099__F1 Predicted insulin signaling pathway in schistosomes based on the characterization of schistosome insulin receptors, the published S CBL FOXO1 GRB2 MTOR PMC8602684__F2 Metallothionein 1: A New Spotlight on Inflammatory Diseases STAT3 STAT1 MMP9 PMC11585094__F7 Potential ferroptosis and osteoporosis biomarkers through TMT proteomics and bioinformatics analysis TF SLC3A2 KEAP1 GPX4 NQO1 SLC7A11 PMC11375557__F1 Mechanisms of Epithelial-Mesenchymal Transition CDH2 EGF PMC11697870__F5 Multifaceted biological processes and pathways that are identified to be associated with AD progression GP6 BCR ABCB1 PMC5375109__F1 miR-33 regulation of adaptive fibrotic response in cardiac remodeling DROSHA ABCA1 CCND1 CDK4 PMC1172066__F8 Model depicting how inner ear polarity is generated in response to extracellular signals GBX2 PAX2 SHH PMC4201594__F6A FOXO3-mTOR Metabolic Cooperation in the Regulation of Erythroid Cell Maturation and Homeostasis PGAM1 HEL-S-133P HEL-S-68p HEL-S-162eP LDHB HEL-S-87p HEL-S-26 PMC3746754__F2 Iron metabolism in the eye, a review TFR2 PCBP1 HFE CP PMC8640549__F3 GPR56/ADGRG1 in health and disease CD81 ARHA RHO TNF PMC4613459__F2 Repurposing metformin: an old drug with new tricks in its binding pockets RHEB STAT3 TSC1 IGF1 IGF1R CCND1 PMC4823983__F5 Interaction between the genes differentially expressed in response to HDM CCL22 IL33 CCR3 IL2RA CCL2 IL-21 IL18 FOXP3 CCR8 CCL17 IL10 CCL11 TNFRSF4 IL13 IL17A AREG TNLG2B EPX ICOS IL25 CCL24 PRG2 RAF3 ADRB2 CCR4 CCL4 PMC8635240__F8 VDR Signaling via the Enzyme NAT2 Inhibits Colorectal Cancer Progression NR1i1 NAT2 STAT3 JAK1 PMC2859139__F1 Immunoregulatory pathways CD40 IFNG TGFB1 PMC3017908__F6 Major pathways affected in NMSC HHIP ARRB2 SUFU SHH PTEN GRB2 PMC136456__F7 The modulation of cellular signaling pathways by NS5A BAD GRB2 PMC8606660__F6 Intrinsic Mechanical Cues and Their Impact on Stem Cells and Embryogenesis LATS1 MOB1A MOBKL1A LATS2 ANKRD1 ARHA NF2 RUNX2 PMC6072898__F3 Mechanistic aspects of the antioxidant and anti-inflammatory action of berberine UCP2 RHO SIRT1 PMC6537107__F3 Changes in PUFA metabolomes are conserved across pharmacological and physiological models of skeletal muscle injury LTB TH LTA HP PMC6008965__F2 5-Fluorouracil drug pathway demonstrating the interaction of multiple gene products TH REN FH DTYMK RRM2 DPYS HEL-S-11 DUT GGH FPGS PMC8469789__F3 Ubiquitin-Specific Proteases: Players in Cancer Cellular Processes FANCD2 FLT3 FAS PCNA PMC9379326__F2 Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets LPL ACOX1 FAS CYP7A1 PMC8568546__F3 RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A SMAD2 YTHDF2 NODAL YTHDF1 METTL3 PMC8568546__F1 RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A SMAD2 WTAP METTL14 NODAL METTL3 PMC9600852__F1 Molecular Defense Response of Pine Trees (Pinus spp.) to the Parasitic Nematode Bursaphelenchus xylophilus LOX STS PMC8877616__F1 Current and Emerging Medical Therapies in Pituitary Tumors TGFBI DRD2 PRL EGFR SMAD2 SMAD4 MTOR PMC9149431__F3 All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity FAS TRADD MLKL CYLD TRAF2 FADD PMC5649110__F1 Narni-Mancinelli et al ZAP70 IFNG SYK CFP XCL1 SLC7A5 EGR2 PMC9188247__F8 Intramyocardial injected human umbilical cord-derived mesenchymal stem cells (HucMSCs) contribute to the recovery of cardiac function and the migration of CD4+ T cells into the infarcted heart via CCL5/CCR5 signaling CCR5 CCR2 CCL5 CCL2 PMC4967210__F13 Schematic summary of novel TXNIP-NFYA-SREBP2/miR-33a-AMPKA/CROT/CPT1/HADHB signaling pathway conferring TXNIP regulation of myocardial fatty acid oxidation HADHB TXNIP CROT NFYA PMC6579706__F1 Unfolded protein response (UPR) EIF2A XBP1 PMC2722767__F3 Application of SysPTM tools ROCK2 APC CER1 SMAD4 ARHA NLK PROC CTNNB1 PMC11670700__F1 Inhibition of the canonical Wnt/Beta-catenin signaling pathway by BI 905677 RNF43 LRP5 ZNRF3 LRP6 TCF4 CTNNB1 PMC4022110__F1 Schematic overview of MBL-dependent activation of the lectin pathway of complement C6 HEL-S-62p C2 C4A C4B_2 PMC9204405__F1 Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research STAT3 IL10 CCL3 CCR2 IL6 CCL2 PMC4441295__F5 Fangchinoline inhibits the growth and invasive potential of gastric cancer cells by inhibiting the PI3K/Akt pathway BAX GSK3B MMP2 CDK2 MMP9 PMC3672943__F1 Integration of Cell Signalling Pathways into Higher Order Networks Sculpts Transcriptional Landscapes FOXH1 TBX5 RUNX2 CTNNB1 PMC3635745__F1 Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways SYK CD81 CD79B CD72 BANK1 CD22 PTEN CD19 BLK PTPN22 BTK FYN CSK LYN PMC10888650__F1 Potassium’s (K+) Role in Various Cellular Processes JUN FAS CASP8 CAD IGF1 HEL-S-162eP CASP3 IGF1R GRB2 FOS IRS1 FADD PMC10888650__F4 ABCC8 Expression in Hypoxic and Inflammatory Conditions SP1 ABCC8 TRAF2 MYD88 PMC6819784__F2 Macrophage infection affects host metabolic state and can induce an M1 profile UCP2 IFNG IFNGR1 F2 TLR4 HIF1A PMC3427885__F4 Impact of HCV infection on ILK signaling RHD COX2 EPOR F8 PTEN MTOR PMC12129893__F2 Sources of the microbiota and mechanisms by which bacteria regulate tumor progression TLR4 CTNNB1 PMC3925803__F5 Model showing elevated calcium and/or phosphate up-regulate HGF secretion and c-Met activation in conjunction with activation of the PI3K/Akt signalling pathway, leading to SMC mineralisation, which can be inhibited by AdNK4 treatment HGF BMP2 NOTCH3 RUNX2 PMC8745708__F4 Neurofibromatosis Type 1 Gene Alterations Define Specific Features of a Subset of Glioblastomas NF1 FOSL1 MTOR RAC1 PMC5129910__F8 Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts IGF2R IGF1R SIRT1 PMC7945682__F2 Summary of targets to generate Super-Treg FAS DHFR LRBA IL2RA HIF1A B2M MTOR CD47 IFNG IL2RB RUNX1 HLA-E MHC2TA USP22 FGL2 AHR HDAC9 HDAC11 FOXP3 HDAC6 PMC4538424__F1 MicroRNAs as major players in immune-mediated beta-cell damage in autoimmune diabetes VAMP2 IL16 IRAK1 PMC8660617__F10 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients ATR PLAT CDC20 CENPH APC INCENP KNTC2 ATM CENPA NSL1 CENPB PMC8660617__F11 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients CDC2 RCC1 RAN ATR CDC20 EGFR APC ATM HCTP4 PMC8660617__F12 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients RAN ATR CDK6 CARM1 KEAP1 E2F4 NR3A2 APC ATM SKP2 CDK4 PMC8660617__F13 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients TH LAMP2 ATR tal-1 BCR IL33 PC ATM GIP RHO XBP1 PMC3539736__F3 PI3K Signaling in B and T Lymphocytes: New Developments and Therapeutic Advances RHEB ICOS KLF2 IL10 CCR6 FOXP3 PMC8660617__F14 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients FANCD2 ATR APC SI ATM SMO PMC8660617__F15 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients MAPK1 MAPK14 RAN ATR UBE2C C13orf34 APC ATM MAPK12 MIF PMC8630697__F3 Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer GPX4 MFN1 MFN2 KRAS PMC9536535__F7 Proposed model of S100A8/9 induction STAT3 TLR4 EBI3 IL27 S100A8 PLA2G1B PTGER4 PTGIR ZBTB40 PMC6813793__F3 Cross talk of Na+ and Ca2+signalling between the cell membrane and the mitochondria.Influx of Ca2+ into cells is mediated by multiple cell membrane pathways MICU1 TRPV1 MCU TRPC6 PMC9225892__F8 Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NFKB Pathways VASP CTSK PMC3690520__F3 TCR signaling pathway leading to NFKB and JNK activation BCL10 APC PMC1160519__F6 Cardiac glycosides inhibit TNFA/NFKB signaling by blocking recruitment of TRADD to the TNFR TRADD TNF TRAF2 FADD PMC6111343__F7 MiR-146a-5p in the Toll-like receptor signaling pathway CD40 TIRAP CTSK TLR9 CD14 CPO TRAF3 TNF TRAF6 IRAK4 RAC1 TLR3 TLR4 LBP CD6 IL9 FADD PMC6050918__F8 Proposed model for CaSR activation of NCC through a PKC-WNK4-SPAK pathway CALU KLHL3 ELL DCT PMC8807488__F3 Emerging Landscape of Long Non-Coding RNAs in Wilms Tumor TCF7L2 DGCR8 CCND2 FOXP2 PMC8807488__F4 Emerging Landscape of Long Non-Coding RNAs in Wilms Tumor SUFU RELB GLI3 PMC6468893__F10 Dual prey-inactivation strategy of the venom of C KCP PMC5397035__F12 Lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement SYK BTK PAK1 PMC7207242__F1 Complement activation pathways and viral evasion of the complement cascade CD59 HEL-S-62p C2 C9 CD55 C4A VCP CP PMC6361575__F3 Smad3 linker phosphorylation negatively regulates transforming growth factor‐B (TGF‐B)/Smad3 signaling EGF HGF SP1 FOXC2 GSK3B SMAD4 LEF1 CTNNB1 PMC4929323__F2 Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury ERBB3 STAT3 NRG1 ERBB4 LIF RHO MTOR PMC12035889__F4 Mechanism of trained immunity and related research TLR4 NOD2 IGF1R MTOR PMC7402325__F3 An ambivalence model of PI3K/AKT/SOX2 signaling and DNA damage control in various stem cell conditions BAX BAD SOX2 CDK2 PTEN MDM2 PMC2867412__F2 Proposed role for AMPK in the kidney in coupling catabolic pathways requiring ATP hydrolysis (primarily sodium transport) with metabolic pathways leading to ATP synthesis (primarily fatty acid and glucose oxidation) EEF2 CFTR MTOR PMC12035889__F2 Signaling pathways inflammation and oxidative stress induced by LPS, HIS, iE-DAP and MDP TLR4 NOD2 CD14 NOD1 MTOR TNF LBP PMC8326121__F6 Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives EGFR APC PMC7402325__F1 The canonical PI3K/AKT pathway with indication of key stimuli and central output functions RPS6 BAX BAD TGFA HK2 SOX2 CDK2 PFKFB2 PTEN MDM2 PMC7402325__F2 PI3K/AKT pathway is a superordinate module of SOX2 and p53 expression control BAX SOX2 PTEN MDM2 PMC8326121__F1 Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives RAD51 NONO PMC7796211__F1 P53 network and metabolism BMI1 MDM4 E4F1 MDM2 PMC7796211__F2 BMI1, ARF, MDM2, MDM4, E4F1, and p53 proteins shuttle between different subcellular compartments where they control different metabolic functions BMI1 MDM4 E4F1 ATF4 MDM2 PMC8156237__F4 Do Autism Spectrum and Autoimmune Disorders Share Predisposition Gene Signature Due to mTOR Signaling Pathway Controlling Expression? HLA-DOB NUP214 LEP LAT NRP1 TUFM PTEN MTOR INS MAPK14 HLA-E GC FLT1 TAP2 CYBA CRP IDE TCF12 TNFSF13 LEPR CD14 VEGFA FOS IRS1 RUNX1 MAP3K1 IGF1 NFKB1 RXRA NFKBIA GAB2 AVP PMC7796211__F3 Several metabolic pathways in which the different components of the p53 network are implicated, including glycolysis, Oxphos, amino acid, and fatty acid metabolism BMI1 MDM4 E4F1 MDM2 PMC9075007__F8 Working model for the effect of SULF2 monoclonal antibody 5D5 on PDGFRBeta-YAP signaling in CCA TF SULF2 CCND1 PMC3916405__F1 Distinct Antiviral Responses in Pluripotent versus Differentiated Cells MAVS TLR3 RNASEL RAC1 PMC3950678__F6 Causal gene network inferred from top discriminative modules at a significance level of 0.005 GLDC PPARG MYL10 SYNJ1 ACADSB DBT DAO ACSS2 HEL-S-182mP AMT SHMT1 MTHFD2L UPP2 MDH2 RXRB GPT IDI2 MYL7 PDE11A ID2 HEL-S-70p DLAT PRKCI AGXT DLD PMC9934381__F11 Model of cGAS-mediated antiviral function in EV-A71, SVV, and FMDV replication TBK1 CGAS IRF3 PMC3579782__F6 Early Activation of Rat Skeletal Muscle IL-6/STAT1/STAT3 Dependent Gene Expression in Resistance Exercise Linked to Hypertrophy STAT3 STAT1 GDF8 IGF1 STAT2 COX2 MYF5 IL4 IL6 JAK1 PAX7 PMC6487091__F3 Mechanisms involved in the prooncogenic activation of the NRF2/KEAP1 pathway JUN KEAP1 BRAF MYC KRAS PMC4869873__F4 Schematics of the inside-out signaling of integrin activation SYK BTK GSK3A c-fgr PIP5K1C JAK3 PLCB2 VAV1 PLCB3 ARHA PMC4436788__F12 Proposed model of arachidonoyl-CoA shunting in LPCAT3-deficient mice LPA TG LPCAT3 PC PMC7940512__F1 BM-resident CD69+regulatory T cells (CD69+ Treg) decrease expression of CD39 which is required for the canonical CD39/CD73 adenosine pathway TIGIT CD69 PC CD160 LAG3 PMC6719876__F3 Analysis of potential roles of combinatorial microRNA regulation in occurrence of valvular heart disease with atrial fibrillation based on computational evidences MAX TAOK2 JUND MAP4K3 CACNA2D4 CRKL AKT3 GNG12 STK4 MAP4K2 PC4 CACNG4 FOS TGFBR1 MAPK14 CRK MAP2K6 PRKCA NLK RPS6KA3 GRB2 BDNF PMC6719876__F4 Analysis of potential roles of combinatorial microRNA regulation in occurrence of valvular heart disease with atrial fibrillation based on computational evidences FZD5 PLCB4 FBXW11 PPP2CA PC4 PPP2R5E CSNK2B FZD4 BTRC CCND2 CAMK2D FOSL1 PRKCA EP300 NLK PMC2729995__F1 Apoptosis and the main anti-apoptotic molecules: Binding of death receptors (Fas, TNF-R, TRAIL-R) to their ligands (Fas-L, TNF, TRAIL) initiates the extrinsic apoptotic pathway TRADD BCL2 TNF FADD PMC7196481__F3 Expression profiling of winged and wingless destined pea aphid embryos implicates insulin/insulin growth factor signaling in morph differences EGF KLF2 EGFR SMAD4 BNIP3 IL7R RAG2 PTEN INS SKP2 FOXG1 IGF1 ATG12 INSR CCNG2 CDK2 ATM RAG1 NLK MDM2 GRB2 PMC11311808__F2 Genetic and Signalling pathway dysregulation in AC LATS1 LATS2 SMAD2 APC SMAD4 NF2 CTNNB1 PMC9541233__F1 Are UMFA (un‐metabolized folic acid) and endocrine disruptor chemicals (EDCs) co‐responsible for sperm degradation? An epigenetic/methylation perspective DHFR SLC46A1 SLC19A1 PMC3376184__F3 Function network built upon genes selected from the identified genetic component PPP2R2C GRIN2B HTR7 ERBB4 GABRA4 TRAF3 GABRG3 FOS FLNA DRD3 CAMK2A CAMK2D AGA BDNF CP PMC5861586__F2 Biological pathways whereby PM2.5 promotes cardiovascular events TLR4 ARC RHO TBP TNF PMC3517092__F1 Schematic depiction of the role of the retromer complex in mediating endosomal protein sorting VPS29 VPS35 RAB7A SNX3 SNX27 PMC9503294__F2 Roles of Skin Langerhans Cells in Immune Tolerance and Cancer Immunity STAT3 AHR DSG3 CD207 PMC7219856__F1 Interactions between the renin–angiotensin–aldosterone system and coronavirus Disease-2019 TMPRSS2 ADAM17 ACE2 PMC4177847__F4 Comparative Transcriptome Analysis Reveals the Genetic Basis of Skin Color Variation in Common Carp WNT5B SFRP5 MC1R ASIP DCT TYRP1 FGFR2 PMC7167370__F8 Possible mechanism of miR-519d overexpression in HCC BAX RAB10 MTOR ATG5 PMC11724471__F1 KRAS proteins and metabolic pathways affected by oncogenic KRAS mutation ACLY GOT2 CD36 HK2 FASN FADS2 MTOR KRAS FADS1 PMC7398104__F5 TGFB1 pathway activation is reduced following RYGB FOXM1 TGFB1 CSF2 ROCK2 ID4 IL18 AHR GREM2 TNF PMC5801739__F2 Aberrant mTOR Signaling and Disrupted Autophagy: the Missing Link in Potential Vigabatrin-Associated Ocular Toxicity? STAT3 GDNF PSMB8 GRM6 GABBR2 VEGFA SOCS3 PRKCB CTNNB1 GABBR1 RHEB ABAT MLST8 MUC5AC GABRE FKBP1A PMC8396471__F2 Fibrotic Idiopathic Interstitial Lung Disease: The Molecular and Cellular Key Players MMP7 SMAD2 AIP SHH CD163 TNF CTNNB1 PMC6904873__F6 PGP-mediated metabolite repair maintains flux through glycolysis and the pentose phosphate pathway PGP HEL-S-162eP GLO1 PMC5214458__F1 Schematic demonstrating the signaling networks and their cross talks involved in differentiating the mesenchymal stem cells (MSCs) into osteoblasts LRP5 MSC LRP6 RHO RUNX2 CTNNB1 PMC9649847__F1 Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury TIRAP TLR4 MYD88 PMC10419152__F1 MAPK signaling pathways in mammalian cells: The MAPK signaling pathways are mediated by highly conserved MAPKs, which are activated sequentially CDC42 TLR1 MOS TLR4 TLR5 ARHA TRAF3 SRC TRAF6 TRAF2 MYD88 PMC10419152__F2 Mammalian MAPK pathways by effector proteins: This figure depicts the various components of MAPK pathways targeted by the bacterial effector proteins CDC42 RHO TRAF6 RAC1 PMC8547127__F1 Tipping the balance: intricate roles of the complement system in disease and therapy C6 CD59 FH C7 HEL-S-62p C1S C1R CD55 C4A CR1 MASP1 C5AR2 SEZ6 C2 C9 C4B_2 PMC8534108__F1 Metabolomic Profiling in Renal Cell Carcinoma Patients: News and Views BAX BCL2 MTOR PMC3785124__F7 Simplified network controlling the fate decisions between osteogenic and adipogenic lineages in huAFMSCs APC FABP4 RUNX2 PMC8052156__F6 Active ingredient-target-pathway network PPARG PYGM MCL1 IGF1R PTGS2 TNF PYGL NR1C1 CDK6 HMGCR MMP3 CDK2 CFTR KDR SIRT1 PMC5292790__F1 Immune response in the polar clinical forms of leprosy NR1i1 CD209 LILRA2 LDLR CD163 PMC3769370__F8 Radioactive 125I Seed Inhibits the Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Triggering DNA Damage and Inactivating VEGF-A/ERK Signaling ATR ATM VEGFA CCNB1 PMC7795223__F1 Transcriptional AHR Signaling Pathway AIP AHR CYP1B1 SRC PMC7447759__F8 Functional annotation network GNG2 ATF3 TNNC1 MAFF CYFIP2 CSRP3 TPM3 MYL2 FHL1 ATP2A2 FOS CP PMC12028195__F1 DNA damage response (DDR) signaling pathway and DDR inhibitors used in clinical settings ATR RAD50 RAD51 MRE11A BRCA1 BRCA2 WEE1 PML ATM CLK2 PALB2 PMC7745059__F1 Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway TBK1 CGAS IRF3 ENPP1 PMC6280669__F2 Proposed TLR signaling network modified from previous reports (; ; ) CD40 CD80 TIRAP CD14 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 RAC1 TLR1 IL1B PMC3223826__F5 JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors CD44 CSA2 HEL113 PTGIS MED27 HEL-S-28 HABP2 ISG15 PMC12047224__F4 NFKB activation via the IKB degradation route is a common mechanism TRADD OTULIN TAB3 TRAF5 IRAK1 RIPK1 TRAF6 CYLD TRAF2 IRAK4 MYD88 PMC9179338__F3 Small but Powerful: The Human Vault RNAs as Multifaceted Modulators of Pro-Survival Characteristics and Tumorigenesis TFEB SQSTM1 PMC11988131__F3 Dual function of PHLDA3 as both an apoptosis inducer and inhibitor PHLDA3 SRXN1 XBP1 GPX1 PMC3221733__F3 Drosophila melanogaster as a model system for human brain cancers RICTOR EGFR CDK2 MYC CDK4 EIF4E PMC7401772__F6 Hypothetical scheme of the regulatory network underlying miR-19b targeted TSLP TSLP IL4 PMC6397564__F6 Critical roles of B3GalT5 and the globo-series GSLs in regulating the apoptosis and survival of breast carcinoma cells CD44 FAS FUT2 EGFR CASP3 B3GALT5 CTNNB1 FADD PMC3959190__F3 Metabolome-based genome-wide association study of maize kernel leads to novel biochemical insights TPR MAL ZFR PMC9634082__F2 Ubiquitin modification in osteogenic differentiation and bone formation: From mechanisms to clinical significance FZD5 SMAD1 CDC20 ITCH SMAD2 SMAD4 SKP2 APC2 RUNX2 TRAF6 TRIM21 CTNNB1 FGFR2 TRAF4 USP4 OTUB2 USP26 TRIM16 RNF185 USP34 JUNB USP9X CBL SMURF1 NEDD4 USP2 RELA BMP2 SMURF2 PMC9592993__F6 Integrating network pharmacology and experimental verification to decipher the immunomodulatory effect of Bu-Zhong-Yi-Qi-Tang against poly (I:C)-induced pulmonary inflammation FLT3 PPARG STAT3 SYK TLR9 CR2 CTSS MYC IRAK4 BCL2L1 PRKCA MMP3 NRAS ADORA2B KDR SRC NR1i1 P2RX7 PLG KLK3 NTRK2 PTK2B VEGFA TNF FOS ADRB2 CDK2 IL8RB CXCR4 HLA-A TH PGR EGFR NR1C2 MTOR ITGAV NOX4 IKBKG TGFBR1 RARA ADAM17 F2 NR3A2 TLR4 F3 AHR BIRC3 BAX SELE KIT MMP9 PTGS2 IL6 FGF2 RORC NR1C1 HEL-S-162eP IKBKB PDGFRA RELA EP300 LCK PMC6413120__F1 The MRN complex and the DNA-damage response RAD50 MRE11A BRCA1 ATM MDC1 PARP1 PMC4695904__F2 Oncogenic miRNAs involved in the apoptotic pathway BAX PTEN BMF CIT PMC10135105__F3 Activation of NRF2 signaling pathway by 4-HNE KEAP1 MAF PMC9145654__F5 TGFBeta-Treated Placenta-Derived Mesenchymal Stem Cells Selectively Promote Anti-Adipogenesis in Thyroid-Associated Ophthalmopathy HMGCR SMAD2 SMAD4 PMC4773776__F4 PKD2 and PKD3 support EMT and cell migration PAK4 PMC3166203__F10 Different ways to activate NFKB SYK TRADD TIRAP RELB TRAF5 IRAK1 TRAF6 TRAF2 IRAK4 MYD88 PMC6014919__F1 KRAS Activating Signaling Triggers Arteriovenous Malformations PIK3CA MTOR PMC5187938__F1 Proposed model of the role of KDM6A/B in definitive endoderm differentiation KDM6B DKK1 WNT3 CTNNB1 PMC3166203__F12 Upstream kinases and redox-sensitive phosphatases in NFKB activation PI3 PTEN TNF PMC3166203__F13 Redoxosome formation in IL-1 signaling IRAK1 TRAF6 RAC1 HEL-S-44 MYD88 PMC7000593__F6 Role and pathway acquired by keratin, cytokines, and interleukins in horn SCC STAT1 IL6 TRAF6 PMC4628872__F1 The canonical and noncanonical regulatory pathways of Nrf2 signaling KEAP1 GCLM MAF ATG5 PMC6311434__F7 Schematic molecular mechanism of SHH pathway regulation by HER2 in breast cancer cells GSK3B SHH PMC8630697__F1 Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer TBK1 STAT1 CGAS STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IL6 PMC4028786__F1 Homocysteine metabolic pathways PMC3356707__F1 Canonical WNT signaling pathway SOX17 VANGL1 APC CHD8 LRP5 CER1 LRP6 NLK CTNNB1 PMC8802512__F2 The S100 protein family in rheumatoid arthritis TIRAP CREB1 PMC11935715__F7 Piezo1 promotes atherosclerotic endothelial inflammation in response to OSS PIEZO1 VCAM1 SRC PMC12229362__F3 Phosphoinositide compartment GPR161 INPP5E PMC4807419__F1 The transcriptional and posttranscriptional regulation of LDLR expression PCSK9 LDLR PMC2766052__F8 The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation TBK1 MAVS IRF3 IRF7 TRAF3 PMC8358777__F7 Exploring the Pharmacological Mechanism of Radix Salvia Miltiorrhizae in the Treatment of Radiation Pneumonia by Using Network Pharmacology TH GAL BAD MAK RXRA RBL2 APP CD19 ME1 FADD PMC8265131__F8 Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways ANXA3 ACSL3 ANXA4 KEAP1 LTC4S ANXA6 ANXA2 HEL-S-7 FACL4 ANXA1 PLA2G5 PTGS2 ACSL1 LOX ALOX5 MAP2K6 PTGIS PLA2G6 PTGS1 PLA2G4B PMC6465568__F2 Signal crosstalk in NFKB transcriptional regulation IRF3 IFNB1 TNF MYD88 PMC6481333__F10 Microarray and pathway analysis of two COMMA-DB derived clones reveal important differences relevant to their developmental capacity in-vivo STAG2 CDC20 PCNA CDC6 STAG1 SMAD2 SMC3 SMAD4 MYT1 SKP2 CDK7 E2F4 CDK2 MDM2 PMC3463893__F2 The inductive and effector sites for the mucosal B-cell response in CD CD40 BCR GC PC PMC6801762__F1 Schematic presentation of the metabolic pathway and transporters that regulate the cellular polyamine levels SLC3A2 SLC22A3 SMOX SLC22A2 PAOX SLC22A1 SLC12A8 PMC5585869__F5 BCR–ABL pathway drives signaling in H929 cells and phosphorylation is inhibited by imatinib SHC1 BCR NPAT GAB2 PMC4822708__F7 CD47 regulation of autophagy ATG5 CD47 PMC2676108__F3 INHIBITOR OF APOPTOSIS (IAP) PROTEINS IN EUKARYOTIC EVOLUTION AND DEVELOPMENT: A MODEL OF THEMATIC CONSERVATION TRADD RELA TRAF2 FADD PMC6148320__F2 Helicobacter pylori infection and inflammatory bowel disease CDX2 NLRP3 ULK1 MUC2 NOD2 HP TRAF6 IL1B MYD88 PMC5396125__F1 Exome Analysis of Rare and Common Variants within the NOD Signaling Pathway TAB3 NOD2 NOD1 BIRC2 BIRC3 PMC2720375__F7 Genome-Wide Screen of Genes Required for Caffeine Tolerance in Fission Yeast TF RAD51 CCR4 ATF1 TPP1 HBA2 PMC4822708__F4 Functional crosstalk between CD36 and CD47 signaling CD36 SRC CD47 PMC5813732__F7 Salvianolic Acid B Enhances Hepatic Differentiation of Human Embryonic Stem Cells Through Upregulation of WNT Pathway and Inhibition of Notch Pathway FGF7A TCF3 HGF NUMB CCND1 LEF1 PMC3358449__F1 Key components in the regulation of methionine metabolism MSRA HEL-S-182mP HEL-S-61p PMC4133953__F8 Cell cycle regulation by miRNA and their targets dysregulated in cervical cancer CDC2 CDK6 FOXO1 CDK2 CCND1 CDK4 PMC4133953__F9 Network for miRNAs involved in migration and invasion of cervical cancer cells SEMA4D SP1 SMAD2 PLG ARHA GALNT7 PMC1618798__F2 Intrinsic apoptotic signaling pathway BAX PROC PMC1618798__F3 Extrinsic apoptotic signaling pathway FAS TNF FADD PMC5763483__F3 Potential cascade of molecular events leading to reduced differentiation of regulatory T cells for prevention of autoimmunity CD93 FOXP3 PMC7375019__F1 Activation of RAGE axis in Sars-Cov-2 infected cells in DM patients HMGB1 NLRP3 DPP4 IL1B PMC9434547__F1 Lactate metabolism in human health and disease YTHDF2 ARG1 PMC7791181__F8 Working model of the target interaction axis after SCI After SCI, TGF‐B1 expression was increased, leading to phosphorylation of the Smad2/3 protein, thereby promoting miR‐21a‐5p upregulation SMAD2 PMC4631256__F2 Epigenetic Mechanisms in Schizophrenia REST BDNF PMC5462018__F5 Conserved ABA signaling pathway in epidermis of H MYB AVP PMC5247472__F1 Vitamin D metabolism CYP2R1 CYP27B1 DBP CYP24A1 PTH FGF23 PMC7938641__F1 Hypothetical concept for the dysregulation of lung epithelial ion and fluid transport by SARS-CoV-2 NHERF1 CFTR ACE2 PMC3524194__F1 Upstream regulators of the Hippo pathway LATS1 LPA RHO PMC8898834__F2 Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection MAVS PDC MTOR PMC4444031__F4 Illustration of the Hedghog (Hh) signalling activation JUN DKK1 APC LRP5 LRP6 ARHA NLK CTNNB1 PMC3023296__F3 Cell cycle, cellular growth and proliferation pathways detected by ingenuity pathways analysis RPS27A FLCN NFYB CDC123 CDKN2A DNAJB12 DISP2 INVS NR2A1 GPR132 PEG10 CNOT3 VPS41 HEL2 PMC8824735__F1 Structure-based discovery of selective CYP17A1 inhibitors for Castration-resistant prostate cancer treatment CYP21A2 CYP17A1 CYP11A1 PMC7655170__F9 Schematic mechanism underlying CUEDC1-suppressed NSCLC progression SMAD2 CUEDC1 SMURF2 PMC11983443__F1 Leptin and adiponectin in health and disease TH STAT3 MTOR PMC9061764__F3 Mechanism identified for ketamine and/or (2 R, 6 R)-hydroxynorketamine (HNK) ID2 S1PR2 ID4 NAMPT MTOR ID1 ID3 PMC4619206__F4 MAPK signaling pathway in CNVRs unique to the susceptible line MAX ECSIT JUND FAS RAF1 CD14 TNF TRAF6 MEF2C NGF MOS NF1 NLK GRB2 BDNF TRAF2 PMC10605254__F5 PDLIMs and TGFB signaling pathway LMO7 SMAD1 SEMA3A DKFZp781O1323 PDLIM7 SMAD2 SMAD4 ARHA PMC10605254__F6 PDLIMs and MAPK and NFKB signaling pathway LMO7 STAT3 HEL-S-112 PDLIM7 LIMK2 PDLIM2 PDLIM3 PDLIM4 PMC10605254__F4 PDLIMs and integrin signaling pathway LMO7 HEL-S-112 PDLIM7 PDLIM2 PDLIM4 PMC3539824__F2 Opening Pandora’s jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders CDK5 FYN GSK3B NRP1 PMC8773595__F1 Clinical Significance of the Duality of Wnt/Beta-Catenin Signaling in Human Hepatocellular Carcinoma FOXM1 NR2A1 CTNNB1 PMC7370863__F1 VG9/VD2 T‐cell response to microbial antigens and self‐phosphoantigens—the little things that give it away IPP BTN2A2 BTN2A1 PMC4265312__F2 TLX: A Master Regulator for Neural Stem Cell Maintenance and Neurogenesis IL16 ASCL1 PAX2 BMP4 POU5F1 SOX2 WNT7A PTEN BCL11A PMC8773595__F2 Clinical Significance of the Duality of Wnt/Beta-Catenin Signaling in Human Hepatocellular Carcinoma APC GSK3B LRP5 LRP6 TCF4 CTNNB1 PMC8734057__SF1 Intricate relationship between SARS-CoV-2–induced shedding and cytokine storm generation: A signaling inflammatory pathway augmenting COVID-19 ADAM17 TNF ACE2 PMC2089068__F3 Relative transcript levels for genes from carbon central metabolism for PB12 (first value) and PB13 (second value), as compared to JM101 RPE SDHA SDHB MAL GALP SDHC TNLG7C CIT PMC5833436__F8 miR-146a-5p and TLR4 signaling TLR4 SMAD2 IRAK1 TRAF6 MYD88 PMC2089068__F4 Relative transcript levels for genes from carbon central metabolism for L-Phe overproducing strains RPE SDHA SDHB RPIA MAL GALP SDHC TNLG7C CIT PMC3810677__F1 Regulation of the HIF pathway by oxygen dependant and independent mechanisms (a) Under normoxia, prolyl hydroxylase domain proteins use oxygen and Alpha-ketoglutarate as substrates to hydroxylate conserved proline residues on HIFA subunits ANGPTL4 EDN1 MTOR VHL PMC7243250__F6 Signaling pathway of Bak’s neuroprotective effect against SAH injury which is suggested in the present study BAX TXNIP MMP9 PMC5755503__F2 Genetic alterations that lead to HIF activation in GBM TH EGF EGFR PTEN MDM2 MTOR PMC12129981__F1 Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review TBK1 CGAS IRF3 TNF PMC12129981__F2 Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review TBK1 CGAS NLRP3 IRF3 PMC11617312__F3 Canonical Wnt/Beta-catenin signalling in epithelial homeostasis and HPV-modulated homeostasis NHERF1 SIAH1 APC CTNNB1 PMC10342868__F8 Regulatory mechanism of lncRNA 220 PIK3CA TLR4 PIK3R1 MTOR MYD88 PMC8695500__F2 Immune Modulation as a Key Mechanism for the Protective Effects of Remote Ischemic Conditioning After Stroke TH BAX CSA2 CXCL12 TSC2 BAD STK11 TSC1 ULK1 GSK3B CD14 CXCR4 PMC11591885__F2 Leu supplementation leads to tumor cell death by inducing apoptosis and oxidative stress IGF1 IDO1 PMC8146072__F5 Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation HEL107 RPE PTEN KRAS PMC11591885__F1 Action of Leu and its metabolites TSC2 TSC1 EIF4EBP1 RPS6KB1 BCAT2 TBC1D7 SLC7A5 SESN2 PMC4811915__F9 Proposed model for the role of the Wnt/Beta-catenin pathway during odontogenesis DKK1 BMP4 CTNNB1 PMC9963318__F3 MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis POLL POLI MED25 PMC8329443__F3 Vital Roles of LINC00662 in Human Cancers LATS1 FRMD6 PMC6628350__F8 Liraglutide attenuates diabetes-associated neointima formation and pathogenic EndMT via the AMPK pathway SMAD2 IL1B PMC4561307__F8 The changes in soleus muscle gene expression within the TGFB and BMP pathways, with SCI (a) and acute response to treadmill training (b) SMAD1 DKFZp781O1323 FST SMAD2 SMAD6 SMAD4 PMC8327397__F6 Sphingolipid metabolism and the enzymes directly participating in the ceramide synthesis pathway CERK SMS tmp_locus_29 AHR PMC7458277__F5 Interaction network derived from the pathway analysis according to results of the genome-wide association study [GWAS] meta-analysis ST8SIA4 CD40 NCAM2 CACNG3 COMP TRIO SLC2A4 RPS6KA2 MC2R DVL2 EPHA4 SPRY2 CEBPG PLCG2 NUP210 XPOT HRH2 PMC8329443__F2 Vital Roles of LINC00662 in Human Cancers CDC42 HEL-S-79 IF2B1 ATF2 RHO PMC8717932__F1 Targeting Programmed Cell Death to Improve Stem Cell Therapy: Implications for Treating Diabetes and Diabetes-Related Diseases BAX GSDMD ATG3 MLKL CASP3 CAP1 TRAF2 FADD PMC6499473__F1 A Developing Therapeutic Decision Tree for Ductal Breast Cancer with Emphasis on the TNBC Subtype CDKN2A CDK6 PI3 CDK4 PMC11873181__F2 Regulation of mitochondrial quality control by PGAM5 PGAM5 PARL APC LRP5 LRP6 CTNNB1 PMC7226287__F8 BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma BMP8A TRIM24 KEAP1 PMC7467727__F5 MTOR regulation of oRG morphology CDC42 MTOR CP PMC6941425__F6 Targeting citrulline-specific B-cells using a CCP-STAL BCR CD22 CP PMC4949115__F2 M2a polarization JAK3 IRF4 JAK1 TYK2 PMC9094111__F1 Calcium Mediated Cold Acclimation in Plants: Underlying Signaling and Molecular Mechanisms CBL MYC PMC5795461__F1 Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses NLRP3 TLR3 TLR4 TLR8 NOD2 IRF3 IRF7 TLR7 TLR10 PMC5113305__F1 Molecular mechanisms supporting the proliferation of HCC cells despite serum withdrawal HMGCS1 OXCT1 HMGCL BDH1 SP1 PMC8441304__F6 SUMO‐mediated DNA replication‐independent DPC repair SPRTN RNF4 TRAIP PMC8927970__F1 Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity TBK1 TIRAP TAB3 TLR9 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 TLR7 TRAF2 PMC8185231__F1 Vitamin D: Possible Therapeutic Roles in Hepatocellular Carcinoma STAT3 MTDH AFP TXNIP HDAC2 PMC9231436__F2 Next-Generation Anti-Angiogenic Therapies as a Future Prospect for Glioma Immunotherapy; From Bench to Bedside FLT3 EGF CASP9 BAD GAL HGF TGFA PIM1 EGFR APC GSK3B LRP5 FLT3LG LRP6 HIF1A RHO PIN1 KITLG CTNNB1 COX2 F2 MDM2 CCND1 CDK4 PMC8359396__F1 Pharmacological validation of TDO as a target for Parkinson’s disease HEL-S-90n KYNU KMO HAAO PMC5654107__F5 Model of metabolic processes upregulated in aerial and in root cells TF HEL60 ACO2 PGM2 FBP1 NOM1 ARG1 HEL-S-4 PCK1 HES1 THRA CP PMC3931120__F7 In Utero Exposure to Second-Hand Smoke Aggravates the Response to Ovalbumin in Adult Mice SAA1 CCL24 CXCL13 CCL7 SELP TOP2A VCAN CP PMC6139224__F6 Diseases and functions analysis by integrated pathway analysis using 20 MeDEGs LTBR C3AR1 PLAUR PAG1 CTSZ CTSG SPI1 PRKCH RUNX3 NFE2 PRF1 FYN F2R CTSO ELANE PMC6195682__F4 Cytokine/chemokine driven JAK-STAT pathway in transgenic spleen CCL3 CCR2 CCR3 CTSS C4A CCL2 GRK4 CSF3R HLA-E OSMR CCL7 BMF MX1 TAP2 SRC GHR GBP2 PIM1 C1S IRF9 CD14 IRF7 GBP1 CXCL10 FOS DDB2 C2 IDO1 IL7 IL6ST LYN BCL6 PMC5789890__F3 Representation of the DNA methylation modifications that occurred within the PI3K/AKT KEGG pathway following 7 weeks of reloading in human subjects TSC2 BAD TSC1 BCR PTEN ME1 MDM2 MTOR PMC3615616__F1 Self-renewal and differentiation of gastric stem cells EGF ARF1 IGFBP2 FADS1 GKN1 MUPCDH PGC TFF2 MUC5AC TFF1 MUC6 PTHLH FOXQ1 CALM1 SHH PMC6491463__F3 Schematic depiction of the CD38/CD203a/CD73 adenosinergic pathway as a major mechanism of the acquired resistance to anti-PD-1/PD-L1 blockade within the BM niche RARA PMC6491463__F1 The purinome in the MM environment under bone marrow niche metabolic reprogramming HEL-S-133P ADA PMC3888787__F1 Bile acid synthesis occurs by two pathways, the classic ‘neutral’ pathway and the alternative ‘acidic’ pathway AKR1D1 CYP7A1 HSD3B7 CYP27A1 PMC5691655__F1 DNA damage repair (DDR) factors regulate cccDNA formation, expression, and degradation SMC6 POLK SMC5 PMC5691655__F2 HBV components interact with DDR pathways and proteins OGG1 DDB1 SMC6 SMC5 PMC3383804__F5 HCMV management of the PI3K/AKT/mTOR pathway RHEB TSC2 RICTOR TSC1 EIF4E PMC8540355__F1 Pathogenesis, Molecular Mechanisms, and Therapeutic Potential of the Interferon Pathway in Systemic Lupus Erythematosus and Other Autoimmune Diseases TBK1 CGAS MAVS TLR9 IRAK1 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR3 TLR4 TLR8 TLR7 PMC9266881__F2 Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression STAT3 ORAI1 EGFR STIM1 SMAD2 TRPC4 TRPC1 TRPC5 MTOR CA3 HEL-S-11 IL8RB TRPC6 PMC8507780__F10 Alterations in HLA Class I-Presented Immunopeptidome and Class I-Interactome upon Osimertinib Resistance in EGFR Mutant Lung Adenocarcinoma HEL-S-99n ERAP1 STX16 ATG2A HEL-S-269 LNPEP VPS37B PSMB10 TAP1 B2M PMC9316990__F3 Potential Roles of Dietary Anthocyanins in Inhibiting Vascular Endothelial Cell Senescence and Preventing Cardiovascular Diseases ATR ATM MDC1 PMC8065041__F10 This study STAT3 NOS2 FOXP3 CD163 PMC8144465__F4 Cannabidiol Modulates Mitochondrial Redox and Dynamics in MCF7 Cancer Cells: A Study Using Fluorescence Lifetime Imaging Microscopy of NAD(P)H BAX TRPV1 PMC7672029__F4 Flowering and sex determination metabolic pathways: identification of candidate genes underneath the QTLs TF CRY1 F11 AGL PMC5719056__F1 The mevalonate pathway leads to cholesterol synthesis HMGCR FDPS FDFT1 PMC9463773__F1 Diversification of PAR signaling through receptor crosstalk APC RHO RAC1 PMC9463773__F2 Diversification of PAR signaling through receptor crosstalk EGF CA12 COX1 COX2 TLR4 SMAD2 IRF3 RHO SRC TGFBR1 PMC4588110__F1 PI3Ks signaling during G2/M progression and mitosis phase CDC2 APC PLK1 PMC5596340__F5 Metabolic reconstruction of the candidate phylum members PAUC34f, Parcubacteria (OD1), Peregrinibacteria, and ACD39 (Bin 13) TH SHE PMC7157488__F1 Crosstalk between RNA metabolism and cellular stress responses during Zika virus replication TBK1 MAVS TLR3 STAT2 TLR4 ALKBH5 METTL14 IRF3 EIF2A PMC2615542__F2 Luteolin, a flavonoid with potentials for cancer prevention and therapy BAX RELA FADD PMC3880642__F1 Smoking and microRNA dysregulation: a cancerous combination EGF BAD TGFA EGFR GSK3B PTEN HIF1A MTOR ARHA MYC SKP2 CDK6 SLIT2 ADAM17 TLR4 PAH HOXD1 ZEB2 MDM2 ADAM8 SRC FHIT RDX PMC8994563__F7 Targets Exploration of Hydroxychloroquine for Pigmentation and Cell Protection Effect in Melanocytes: The Clue for Vitiligo Treatment MLPH PAX3 ACHE DTNBP1 RAB27A MC1R MSRB3 UVSSA PNMT SOX10 BLOC1S5 PMEL PMC4111847__F4 Glycolysis and the triacylglycerol biosynthetic pathway in Cp0710 MCAT HEL-S-162eP PMC6624447__F5 Canonical pathways generated in Ingenuity Pathway Analysis of interferon signaling pathway of DEGs in (A) T helper cells, (B) T cytotoxic cells, (C) monocytes, and (D) B lymphocytes of infected goats at 9 dpi SOCS1 BAX CAST IFITM2 FITM2 STAT2 PSMB8 PSMB3 IRF9 IFIT1 IFIT3 TAP1 IFI35 PIAS1 JAK1 TYK2 PMC6624447__F6 Canonical pathways generated in Ingenuity Pathway Analysis of Oncostatin M signaling pathway of DEGs in (A) T helper cells, (B) T cytotoxic cells, (C) monocytes, and (D) B lymphocytes of infected goats at 9 dpi CHI3L1 MT2A TIMP3 OSM OSMR MMP3 GRB2 PMC6769697__F1 Schematic depiction of copper and platinum distribution in tumor cell ATOX1 CCS LOX ATP7B COX17 HEL-S-44 ATP7A PMC9100382__F3 Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies STAT3 SIRT3 HMGB1 GULP1 MEGF10 GPC6 SIRT2 ABCA1 SIRT1 SIRT6 PMC3159179__F4 Methionine-Hcy metabolism PMC6315366__F4 Autophagy, Keap1 and p62 regulate Nrf2 in HCC TBK1 KEAP1 ULK1 MTOR PMC3699421__F2 Reactivation of HIV-1 transcriptional latency HEXIM1 EZH2 SUV39H1 PMC2593508__F8 Fasudil inhibits the myogenic response in the fetal pulmonary circulation GC ARHA RHO PMC5394422__F2 The autophagy pathway and core autophagy proteins WIPI2 ULK1 UVRAG ATG14 STX17 WIPI1 ATG10 LAMP2 ATG3 ATG12 AMBRA1 ATG5 ULK2 PMC9569062__F5 Advances in the modulation of ROS and transdermal administration for anti-psoriatic nanotherapies NPS PMC9374593__F8 Working model that PFKFB3 inhibition plays an important role of deregulating cancer stemness, EMT and chemosensitivity in small cell lung cancer LATS1 CD44 F2 SOX2 NF2 ABCG2 PMC8236950__F5 Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients TMPRSS2 STAT3 ACE2 PMC5011664__F3 Regulation of wingless/int-1 signaling by crosstalk in hepatocellular carcinoma HGF IGF1 GSK3B SMAD4 SPTBN1 CCND1 AXIN2 CTNNB1 PMC5386661__F10 Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance BMI1 GFAP MBP OLIG2 IBSP PMC9058112__F1 Cardiac Remodeling in Heart Failure: Role of Pyroptosis and Its Therapeutic Implications NLRC4 NLRP1 GSDMD NLRP6 NLRP3 AIM2 NLRP9 DFNA5 IL1B PMC8165101__F5 Small molecules in targeted cancer therapy: advances, challenges, and future perspectives SUFU PTCH1 SMO GLI3 PMC8226042__F1 Immunological response to COVID-19 and its role as a predisposing factor in invasive aspergillosis IL10 IL6 TNF ACE2 PMC8165101__F6 Small molecules in targeted cancer therapy: advances, challenges, and future perspectives BAX BIK PMC8165101__F7 Small molecules in targeted cancer therapy: advances, challenges, and future perspectives ATR RAD51 CHEK2 CHEK1 ATM PALB2 PMC3224542__F1 Genes related with the tau protein phosphatase-2A (PP2A) pathway PPP2R2A PPP2CA LCMT1 PIN1 PMC3394960__F10 A schematic model for the role of ANXA2 in the pathogenesis of adenomyosis ANXA2 VEGFA CTNNB1 PMC2933174__F6 Model depicting a novel mechanism by which cetuximab induces autophagy EGF BCL2 MTOR PMC3317440__F2 Strain-specific host gene networks activated in Mtb-infected BMM STAT3 PPARG EGF ITGA4 JAZF1 STARD4 PTK2B HDAC1 MECR HBEGF NR1C1 CCR7 CISH CCND1 IL12RB1 PMC3174390__F1 TGFB/Smads and crosstalk pathways in renal fibrosis and inflammation SMAD2 SMAD4 IL1B PMC9503046__F4A Antimicrobial Peptides and Biomarkers Induced by Ultraviolet Irradiation Have the Potential to Reduce Endodontic Inflammation and Facilitate Tissue Healing EGF SNAI2 CSF2 TGFA RAF1 MMP10 EGFR MMP9 TNF TRAF6 MAP3K14 RAC1 FGF2 FGFR2 IFNG FGF7 HBEGF PRKCA MAP3K7 MAP2K1 CEBPB TRAF2 PMC11607510__F3 Glucose metabolism reprogramming of VECs PIM1 HEL-S-133P F2 HK2 GCKR VCAM1 PMC7267399__F2 Possible life cycle of SARS‐CoV‐2 and potential intervention strategy TMPRSS2 HEL-S-69p ACE2 PMC3174390__F4 Inhibitory role of Smad7 in renal fibrosis and inflammation SMAD2 SMAD4 IL1B PMC11607510__F4 Glucose metabolism reprogramming of VECs in atherosclerosis CDH2 SIRT3 ROCK1 LDLR TIGAR VCAM1 ARHA MTOR ATG5 PRKAA1 PMC6850169__F1 Simplified lipid metabolic pathway in maize OGA LPA PGP FAS PMC6748048__F1 Kinase Activation Mechanisms in the Hippo Kinase Cascade SLMAP NF2 FGFR1OP2 STRN PMC4463932__F2 Glycosylation pathway defects with known immunologic consequences JAGN1 G6PC3 ALG12 SLC35C1 GCS1 SLC37A4 PGM3 CCR5 ALG1 SLC35A1 PMC6748048__F3 Upstream Regulators of the Hippo Pathway in Drosophila and Mammals PATJ HEL-S-28 HEL70 PALS1 RHO VGLL4 MYD88 LATS2 INSM1 CRB3 AMOT APP SCRIB NF2 SRC PMC6748048__F4 Hippo Pathway Mutations in Human Diseases LATS1 LATS2 GNA11 NF2 PMC6506890__F4 Mevalonate Pathway GGPS1 HMGCS1 IDI2 ACAT1 HMGCR ACAT2 IDI1 FDPS MVK PMC11577197__F1 CD8+ T cell differential hierarchy upon antigen exposure TIGIT CD69 KLRG1 CCR7 TOX PMC7005447__F5 Proteomics-guided metabolite supplementation strategy for arRP ACO2 HK2 FASN CS HEL-S-30 SDHA PDHA1 SUCLA2 C2 OGDH HEL-S-32 ENO1 PFKL HEL-S-26 PMC11577197__F2 Immunoediting in acute myeloid leukemia: Reappraising T cell exhaustion and the aberrant antigen processing machinery in leukemogenesis CD80 TIGIT BATF CD37 TOX IRF4 PMC9519863__F2 Gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis FGF8A LOX NLRP3 CYP8B1 SPHK2 TLR4 IL18 CXCL2 IL8RB MYD88 PMC8834247__F4 Put in a “Ca2+ll” to Acute Myeloid Leukemia CXCL12 HIF1A CXCR4 PMC8834247__F5 Put in a “Ca2+ll” to Acute Myeloid Leukemia ZAP70 IFNG CD80 BATF IRF4 PMC3721836__F9 Simplified model of Rac1 signaling and function in learning-induced adult neurogenesis JUN DCX GADD45B BDNF RAC1 PMC8834247__F3 Put in a “Ca2+ll” to Acute Myeloid Leukemia BAX FAS ORAI1 KDM2A MFN2 PML ATM PTEN MTOR HEL-S-26 FADD PMC4367602__F2 Ligand stimulation of ERK and PI3K signaling in BRAFV600E melanomas SPRY2 EGF HGF BRAF EIF4E PMC8081956__F3 Autophagy in Hepatic Steatosis: A Structured Review ATG101 ATG10 ATG3 ATG12 KEAP1 ULK1 ATG14 ATG5 PMC2878851__F3 Protein Interaction Network Underpins Concordant Prognosis Among Heterogeneous Breast Cancer Signatures PSMD12 PCNA MAP4 APC SPARC TSG101 PTEN STAT1 CCNE1 MCM10 AURKB E2F3 GINS2 MCM3 CREBBP MMP2 EN1 CCNB1 PMC6023743__F1 A well-studied example of modulation of phospholipid signal transduction cascade in the nucleus is turnover of inositol phospholipids, especially phosphatidylinositol-4,5-bisphosphate (PIP2) LPA PLCG1 PLD2 PLCB1 PC PMC5910322__F6 Pro-apoptotic mechanisms of miR-217-5p regulating the ERK-MAPK pathway at different sites MAPK1 BAX PRKCI BAD BAG3 SOX2 BRAF BCL2 GRB2 KRAS ITGAV RAC1 PMC1635984__F3 MRNA expression levels in TGFBeta-treated T84 epithelial cells compared to control cell culture MAPK1 EGF SOS1 EGFR APC PTEN DVL2 IGF2 CTNNB1 RBX1 FZD4 GRB10 IGF1 SOS2 CREBBP SKP1 RRAS WNT4 NLK GRB2 LEF1 PMC9335290__F2 CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases CDH2 BAX ITCH PC PTEN FOXK2 HOXB13 MTOR CCND1 CTNNB1 PMC2878851__F1 Protein Interaction Network Underpins Concordant Prognosis Among Heterogeneous Breast Cancer Signatures CDC20 CDKN1A APC NEK2 MAF SPARC MCM3 PTEN CCNB1 PMC7797150__F4 Prediction of target genes and circRNA-miRNA-mRNA network FUS DGIC RTP4 COLEC12 ZBTB7A ID4 IKZF3 MED17 ACVR2A SLC24A4 TGFBR3 VGLL4 SOS2 RMND5A PPP1R1A VCAM1 TP53RK PYROXD1 SLC30A9 ANKRD49 ZFP3 VPS13D RFX3 GAPVD1 TGFA FRMD3 RAB31 SYNPO2L TMEM33 TAB3 TGIF2LX TGIF2LY STK4 CDC42EP1 PPP2CA TGIF1 DNAJC9 ADNP SEC22C TGFBR1 DCTN5 INSIG1 TGFBR2 KMT2A STAU1 NUFIP2 SLC41A2 TGFBRAP1 ACVR1B GLG1 MLLT6 ARHGAP21 SNX4 SYNGR1 PXDN GRPEL2 ZNF549 C10orf104 MLXIP MCTS1 ZFHX3 SPAG7 SYNRG FSTL3 SEMA4C ORMDL1 UBE2G1 SSH2 SFRS3 RRM2 NABP2 GJB7 EPHA4 YTHDF1 KRAS SFRP1 ARPP19 MAP3K7IP1 SUI1 NRBF2 RGS4 DDX3X PMC3874316__F7 Antcin C-induced upregulation of antioxidative gene expression via the Nrf2/ARE signaling pathway and suppression of AAPH-induced apoptosis in human hepatic HepG2 cells BAX KEAP1 NQO1 MAF BCL2 APAF1 PMC6381446__F2 Schematic representation of the role of oxysterols in the Hh signalling pathway PTCH1 SHH SMO PMC2686735__F5 Map of BCR-pathway CDC42 BAD MAPK13 GSK3B BLNK PTEN VAV1 SHE RAC1 HRAS LYN GRB2 BIK PMC7308426__F5 Calcium signaling pathway ALB PLN CAV3 ORAI1 BCR STOM MCU DAO PMC7308426__F6 Pathway in cancer RARA PTEN PMC5814934__F6 Working model BRD4 RBPJ NOTCH1 PMC9146014__F1 Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses CAD CDA UCK2 CMPK1 UMPS DHODH PMC5977747__F2 Possible scenarios for PanDrugs therapeutic candidates EGF HGF EGFR MTOR PMC8980477__F1 Contribution of Interleukin-17A to Retinal Degenerative Diseases TRAF4 IL17RC EBP IL17RB TRAF5 TRAF6 TRAF2 PMC5997132__F4 Main pathway targeted using siRNA delivery systems in oral cancer.Notes: Examples of siRNA therapeutics alter multiple hallmarks applied for oral cancer CIP2A ANGPTL4 BAG3 HAS2 CXCR4 CD47 SOX4 PMC3823960__F6 Summary of retinoid pathway CYP26B1 LRAT HEL111 CYP26A1 PMC9671909__F6 Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models TH IKBKAP PMC8347567__F10 Fedratinib Attenuates Bleomycin-Induced Pulmonary Fibrosis via the JAK2/STAT3 and TGFB1 Signaling Pathway STAT3 PMC3607680__F3 The one carbon cycle PMC5080925__F6 Model showing association of PAX5, CD19, CD3, p53, Ras, Raf, MAPK and Zap70 in B-cell and T-cell type non-Hodgkin's lymphoma ZAP70 PAX5 CD19 PMC4292048__F3 TRAF4 function on TJs TRAF4 SMURF1 USP15 ARHA SMURF2 PMC6078642__F7 Enzymes necessary for local aldosterone synthesis are present in muscle-derived leukocytes STAR CYP11B2 CYP11A1 PMC6763548__F1 Scheme illustrating the actions of adiponectin/AdipoR agonist, AdipoRon, in the liver and the muscle UCP2 HEL60 NR1C1 ADIPOR1 ADIPOR2 CAMKK1 SIRT1 PMC3439965__F3 Simplified overview of the canonical Wnt signaling pathway FRZB DKK1 APC PMC4118716__F2 Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis STAT3 JAK3 STAT4 JAK1 TYK2 IL1B GATA3 PMC7879595__F2 Among P2X receptors, the P2X7 is highlighted within the context of BC CD44 ELL CTNNB1 PMC7879595__F1 The TME of solid tumors has the common characteristic of hypoxia (1% O2), which is due to a low supply of nutrients and oxygen BAX BCL2 PMC5514966__F4 Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target STAT3 RAF1 EZH2 SET NOTCH1 CTNNB1 PMC3390960__F1 Formation of the COPII vesicle on the surface of the endoplasmic reticulum SEC31B SEC31A SEC23A SAR1B SAR1A SEC24C SEC23B PMC3417062__F7 Molecular mechanisms underlying PA and histologically anaplastic PA RAF1 NF1 EGFR BRAF PTEN PMC7923229__F3 TRIM5Alpha-mediated regulation of innate immune signaling and molecular inflammation TRIM50 ULK1 TLR4 TAB3 TRAF6 PMC9237441__F5 Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities STAT3 BAX BAD AXL BCL2 APAF1 PMC6054220__F2 Autophagy induced by nutrient and nutrition stresses via the mTOR and AMPK signal pathways RHEB MLST8 TSC2 MTOR DEPTOR PMC4218725__F6 Shigella dysenteriae Modulates BMP Pathway to Induce Mucin Gene Expression In Vivo and In Vitro CDX2 MUC5AC MUC2 SMAD4 PMC5527897__F2 N‐linked glycosylation ALG8 SLC35A3 ALG6 ALG10 MGAT3 ALG13 MGAT2 ALG1 ALG3 PMC4051845__F1 DNA double-strand break repair pathway choice and cancer BARD1 BRCA1 RIF1 PMC8268913__F6 Transcriptional Modulation of the Hippo Signaling Pathway by Drugs Used to Treat Bipolar Disorder and Schizophrenia LATS1 NF2 CTNNB1 PMC8365911__F4 Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants BBS10 SLC25A5 EHD3 AEBP1 NDRG2 SLC7A1 THSD4 WASF3 RGCC RIOK3 RCC2 PBX1 ESYT2 MYC MBIP HEL-S-29 CD9 HEL-S-2 PTMAP7 CNTFR ENG MCM3 IGFBP7 GADD45A LAMA3 KLF2 AKT3 PRKAG2 IGFBP4 GGT7 IGFBP6 TYRO3 CDA ADAM12 AMFR FRZB AOX1 TLN2 MAFB STC2 DAAM2 HEL-S-34 HEXB RPL10A HEL-S-162eP RHOB HOXA10 CTBS NFKBIA NEO1 RPS12 PTGES TSPYL2 P3H2 ARHGAP10 KAT2B PMC5527897__F5 Ganglio‐series glycosphingolipid synthesis pathway UGCG B4GALNT1 ST8SIA1 B3GALT4 ST6GALNAC6 ST3GAL1 PMC4118716__F4 M1 and M2 macrophage polarization CCL22 CCL18 CXCL10 CCL2 IL1B CCL17 PMC2712666__F3 TNF superfamily: costimulation and clinical applications CD27 PI3 TNLG8A TRAF2 PMC7607850__F1 ZA inhibits the RANKL/RANK pathway NFATC1 MTOR TRAF6 PMC5509628__F2 Cav1.2 and Cav1.3 signaling mechanisms CA12 EIF2A PMC4811021__F1 Diagrams of the Hippo signaling pathway in (A) Drosophila melanogaster and (B) mammals highlight the core kinase cascade and upstream regulatory signals LATS1 PMC7855207__F1 Expanding the Clinical and Metabolic Phenotype of DPM2 deficient Congenital Disorders of Glycosylation DPM2 DPM1 DPM3 PMC9639813__F6 Key neuronal signalling pathways are downregulated in fast growing in vivo juvenile liver fluke POR SYP PMC9602136__F14 Deciphering the Key Regulatory Roles of KLF6 and Bta-miR-148a on Milk Fat Metabolism in Bovine Mammary Epithelial Cells PLTP ME1 PMC7762867__F1 Inflammatory signaling pathway in macrophages TLR4 NFKB1 MAL RELA IRAK1 IRAK2 TRAF6 TNF IRAK4 MYD88 PMC2847521__F11 Proposed model for the I3C disruption of a cross-regulatory positive feedback loop involving expression of GATA3 and ERA by stimulating the degradation of ERA protein RBX1 AHR GATA3 PMC5777301__F1 Type I Interferon signaling pathway STAT1 STAT2 IFNAR2 IRF9 USP18 IFNAR1 ISG15 JAK1 TYK2 PMC6349473__F2 Developmental processes regulate craniofacial variation in disease and evolution TCF12 SUFU SMAD6 SHH SMAD4 SMO RUNX2 TWIST1 PMC11820753__F3 Impact of CR on different nutritional pathways indicating how it promotes anti-cancer activity RHEB TSC2 TSC1 IGF1 IGF1R MTOR PMC6874456__F8 Schematic model of how TG NPs ameliorate CKD progression TG NPS PMC3670604__F4 Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma HEL-S-99n HEXA TNPO1 H2AX CLU VEGFA HEL-S-87p LMNA PMC1415320__F6 The proposed TGFB1 signaling mechanism that promotes EMT SMAD2 GSK3B SMAD4 CTNNB1 PMC3124345__F2 Schematic representation of the possible mechanisms leading to ovarian cysts in female patients with ORD POR CYP51A1 CYP17A1 PMC7708424__F5 An example of where Pascal pathway enrichment and HotNet2 home in on the same pathway causal of Hyperlipidaemia LPL APOC2 APOC3 APOC1 VLDLR APOE MYLIP ABCA1 APOA2 PCSK9 LIPC ABCG1 APOA4 SORT1 MTTP SCARB1 LDLR APOB HNF1A PMC9386081__F1 Non-coding RNAs in necroptosis, pyroptosis, and ferroptosis in cardiovascular diseases RIPK3 GSDMD TRADD NLRP3 MLKL GPX4 DFNA5 PMC4778854__F3 Changes in the expression levels of genes associated with cell cycle pathway in PC3 cell line after treatment with G CCND2 PRKDC APC EFS PTTG2 PMC11566483__F4 Caspase-3/8/9- and granzyme-mediated pathways RIPK3 BAX GSDMD GSDMC GZMA GSDMB RIPK1 DFNA5 TNF FADD PMC8699546__F6 Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation HMGB1 CD24 TIRAP TLR4 MYD88 PMC8699546__F3 Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation HMGB1 TIRAP TLR4 MYD88 PMC11566483__F2 NLRP3 inflammasome construction and activation GSDMD NLRP3 PTMS TNF PMC11519594__F6 Mechanism diagram of m6A-autophagy-mediated tumor treatment resistance PINK1 IGF2BP3 ULK1 SQSTM1 YTHDF1 MTOR TMA7 ARHGAP5 UBA2 DCP2 FOXO3A YTHDF2 METTL3 ATG5 PMC11519594__F7 M6A autophagy axis involved in tumor signaling pathway network NBR1 TP53INP2 HNRNPA2B1 IGF2BP3 METTL14 YTHDF1 PMC6857915__F6 Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease SIAH1 APC SMAD4 RYK ARHA CTNNB1 BAMBI SOST INVS ZNF3 NOTUM CER1 ZNRF3 SKP1 NLK PMC6857915__F7 Chronic obstructive pulmonary disease GDF8 LEP IL4 NODAL IF2G MPL TG INHA IF2D IL2 TPO IL7 AMH TNLG7C PMC8573870__F11 Effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons STAT3 SMAD2 IL4 PEG3 IL6 TNF IL1B PMC10311769__F2 Revealing of a novel double bond reductase related to perilla ketone biosynthesis in Perilla frutescens IPP MVD MTR MVK PMC7718402__F6 Neutrophil signaling during resolution of inflammation BAX FAS FADD PMC6857915__F8 Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease NUMB PMC9530352__F1 Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases IRF7 MYD88 PMC11947922__F1 Novel mechanism targeting Beta-arrestin-2 for the management of diabetic nephropathy ATF4 XBP1 PMC6775696__F11 Interactions between MKI67 and eight genes related to P53 signaling pathway CDC2 MKI67 GTSE1 CASP8 RRM2 CHEK2 CHEK1 CCNB1 PMC6357032__F2 Classification of caspases BAX MCL1 BCL2 PMC8688805__F2 Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review CD44 IFNG STAT3 CCND2 TOB1 DDIT4 EGFR STAT4 MTOR PMC8493876__F1 Targeting the CD27-CD70 Pathway to Improve Outcomes in Both Checkpoint Immunotherapy and Allogeneic Hematopoietic Cell Transplantation CD40 ICOS CD27 DPP4 LAG3 PMC9705325__F7 Proposed antitumorigenic mechanism of CPX on GC growth STAT3 GC SRC CCND1 CDK4 PMC8492608__F12 Pathological Features of Tumors of the Nervous System in Hereditary Cancer Predisposition Syndromes: A Review CD44 NUMB SMO POLE VHL PMC6829226__F4 LncRNAs regulate EMT signaling pathways SNAI2 SNAI1 SMAD2 APC GSK3B SMAD4 ZEB2 CTNNB1 PMC6033660__F2 Schematics of classical CSR from IgM to IgA CA3 BCR HEL-S-11 PMC7761714__F2 The NRF2 signaling pathway by microRNAs (miRNAs) in cancers BACH1 KEAP1 PRXL2A GCLC MAF HDAC2 SIRT1 HEL-75 PMC9540245__F6 Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis HEL-S-133P HEL-S-68p HK2 HIF1A PMC10625490__F2 HIV infection induces intestinal mucosal barrier damage and immune cell dysfunction, which aggravates the inflammatory response IFNG TLR4 TNF PMC6901542__F6 Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NFKB pathway activation through RPS3 VIT RPS3 LCN2 PMC4486656__F2 Fueling Immunity: Insights into Metabolism and Lymphocyte Function FH GLS HEL-S-133P PHGDH PMC11820997__F3 Beneficial effects of hydroxytyrosol (HTyr) on insulin signaling through the enhancement of insulin signaling pathways IL6 TNF IL1B PMC8858030__F3 Mass spectrometry imaging reveals substrate channeling by the purinosome, a liquid-like multi-enzyme assembly PAICS PFAS ADSL PMC5882318__F1 Analysis of the PI3K-AKT-mTOR pathway in penile cancer: evaluation of a therapeutically targetable pathway PDK2 MTOR PMC4276889__F6 Reduced HIF-1A expression in TRPM2-S-expressing cells determined by proteomic analysis TFAM TFRC HEL113 ENO2 HEL-S-133P HEL-S-162eP NPM1 HSPA4 HIF1A PMC6568224__F1 Necroptosis signaling pathwayNecroptosis can be caused by a variety of stimuli, including the ligands of the death receptor, TLRs, IFN receptors, and certain pathogens RIPK3 CASP8 TRADD TLR3 MLKL TLR4 CASP3 RIPK1 TNF CYLD TRAF2 PMC8761731__F11 Predicting 3D Structure, Cross Talks, and Prognostic Significance of KLF9 in Cervical Cancer STAT3 PGR TPD52 KLF9 RHO MDM2 PMC3890408__F2 Cooperating mutational events in MYC-driven lymphomagenesis and novel therapeutic opportunities.Notes: Continuous MYC expression is required for BL cell survival, as demonstrated by the apoptotic effect of the MYC inhibitor 10058-F4 on BL cell lines MDM4 CDK6 BCR GSK3B PTEN BMF MDM2 ID3 PMC7338604__F1 Wnt/Beta-catenin signaling pathway APC CTNNB1 PMC7338604__F2 Natural products targeting the Beta-catenin signaling pathway for cancer therapy RPL10 PPL CTNNB1 PMC3653932__F7 TLR4 Activates the Beta-catenin Pathway to Cause Intestinal Neoplasia TLR4 APC AXIN1 GPR49 CCND1 MYD88 PMC8651556__F1 Endothelial Dysfunction and Hyperhomocysteinemia-Linked Cerebral Small Vessel Disease: Underlying Mechanisms and Treatment Timing HEL-S-61p PMC2679751__F7 Proposed model for functional interaction between Ncs-1a, Pi4kB, and Arf1 in trafficking and secretion ARF1 BMP4 NCS1 PI4KB PMC9549509__F6 Therapeutic hypothermia alleviates myocardial ischaemia–reperfusion injury by inhibiting inflammation and fibrosis via the mediation of the SIRT3/NLRP3 signalling pathway SIRT3 NLRP3 IL1B PMC10375321__F1 One-carbon metabolism comprising the transmethylation pathway, nucleotide synthesis pathway, transsulfuration pathway and remethylation pathway MTHFD2 MTHFD1 DHFR HEL-S-61p MTHFS PMC3810143__F9 Downregulation of Nuclear-Encoded Genes of Oxidative Metabolism in Dialyzed Chronic Kidney Disease Patients TFAM YY1 NRF1 PMC11084272__F7 Action of multifunctional FYD in preventing cancer metastasis CDH2 MMP2 VCAM1 TNF CTNNB1 PMC5120123__F2 Positive regulatory signaling for Tfh differentiation IFNG STAT3 ICOS TBK1 KLF2 ITCH FOXO1 CXCR5 VAV1 ASCL2 BCL6 PMC5387898__F2 Simplified schematic of the possible mechanism of lymphangiogenesis in cancer cell metastasis EMILIN1 VEGFC SHH PMC4439078__F5 Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes TGFB1 KIF20A CREM ISG20 APOH CEBPD UCN FOXP3 TRIB3 HRK CEBPB CSRNP1 CDCA2 CEBPE MTHFD2 PRRG4 TMEM43 TNFRSF12A MMP19 JDP2 STK40 SOX11 ECT2 KNTC2 ECEL1 OPRM1 FOS CD34 MKI67 ATF3 CEBPA ITGA1 DDIT3 GADD45A PMC7216437__F3 ATM functions in DNA damage repair pathway ATR RAD51 BRCA1 H2AX BRCA2 CHEK2 CHEK1 ATM PALB2 SSB PMC2643928__F1 Activation of the transcription factors IRF3 and NFKB in response to infection with a single-stranded RNA virus CASP8 MAVS TANK IRF3 TRAF3 CASP10 FADD PMC7900405__F6 Schematic illustrating entosis and the actin machinery CDC42 PCDH7 ARHA RAC1 PMC3418847__F6 Interaction Map for PTMScan Direct: Akt/PI3K pathway reagent PIK3CA ATR BAD EPHA2 PIK3R3 PIK3R2 AKT3 GSK3B CTNND1 PIK3R1 PTEN MTOR MINK1 SHB FYN PI4KB RPS6 FOXK1 GOLGA4 EIF4H KHSRP STK24 KRAS IRS1 HRAS RICTOR GSK3A FOXO1 NFKB1 LCK PMC3109507__F1 Choosing the right path: does DNA-PK help make the decision? BARD1 PNKP RAD51 BRCA1 BRCA2 PALB2 BLM PMC8134690__F1 HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis TRIM28 TRIM37 AMBRA1 BCL2 TRIM17 TRIM59 TRAF6 PMC7525032__F6 Scheme of the proposed lung IIR against S TLR4 CXCL1 IL1B MYD88 PMC3162038__F2 Biosynthetic pathway to validamycin A and characterization of VldB, VldE, and VldH MAX PNP PMC7940683__F1 Siglec-G in sepsis STAT3 CD24 TLR4 GSK3B HIF1A SRC PMC7940683__F2 Siglec-G in various immune cells STAT3 CD80 HMGB1 MAVS NFATC1 IRF3 SIGLEC6 CD24 CBL RIGI BCR TLR4 LYN PMC6433784__F1 Mechanism of Action of FSH on Adipocytes UCP1 ATF2 FSHR PMC7387981__F1 Cannabinoids' pharmacology IDE RHO TRPM8 CTNNB1 PMC10478283__F8 Mechanism diagram POU5F1 SOX2 MSC CXCR4 HOXB4 PMC6827009__F6 Activation of CREM signaling pathway in spermatozoa of idiopathic infertile patients post-antioxidant treatment CRP TSSK2 PRKAR1A PMC4510718__F2 Survivin (SVN) pathways to apoptosis BAX FAS CAD TNF PMC10530547__F3 Transcription Factor Zbtb20 as a Regulator of Malignancy and Its Practical Applications PPARG AFP EGFR MMP2 Nbla10317 MMP9 CCND1 CTNNB1 PMC4361590__F7 Repulsive Axon Guidance by Draxin Is Mediated by Protein Kinase B (Akt), Glycogen Synthase Kinase-3B (GSK-3B) and Microtubule-Associated Protein 1B DRAXIN DCC MAP1B GSK3B PMC6396335__F1 Assembly of the interferon (IFN)G receptor (IFNGR) and activation of Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling SOCS1 STAT1 IFNGR2 IFNGR1 PIAS1 JAK1 PMC8103423__F4 Cell biology of Parkinson’s disease PINK1 FYN NLRP3 LRRK2 CD36 IL13 PLG LAG3 IL1B PMC9572491__F1 Mini Review on Molecules Inducing Caspase-Independent Cell Death: A New Route to Cancer Therapy BAX FAS BCL2 PMC3491806__F2 Inflammatory Bowel Disease CCR6 PMC4562633__F3 Discovery of Intermediary Genes between Pathways Using Sparse Regression NPPC TAPBP RAB10 CCL3 RELB IRAK1 MAPK8 PLEK XCR1 GDF15 NOD1 ADORA2B RAB11FIP1 PSME2 MAP2K3 GOLPH3 EIF2B2 PSMB8 PTGS2 OAS3 ETF1 EIF4E MTMR12 GPR85 ABHD17C SMG8 STX11 HEBP1 EME2 ESD CDK5RAP3 RAB8B RAB35 SERPINB2 AP3B1 FAM111A SPOPL PMC4562633__F4 Discovery of Intermediary Genes between Pathways Using Sparse Regression TAPBP TAP1 MAPK6 PSME2 NMI CASP8 TIMELESS STK40 B2M RSAD2 MNDA NPC2 CXCL11 MVP LCN2 JARID2 AP3B1 SPPL2A VDAC3 H2AB1 MMP25 RAB10 ENPP4 LGALS8 VASP SH3GLB1 STARD3 GBP7 SHISA5 TPST1 IFIT2 PROCR SNRPC GRN GLRX ATP10A RAB21 TMEM67 SLC25A22 TMCO3 PARP12 PARP11 MITD1 TNP2 CASP4 NOD2 NOD1 TAP2 ISG15 MOV10 LGALS3BP RRBP1 SP110 RAB32 CHMP4B RAB35 PPP2R5A PMC11747344__F6 Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation BAX SYK BAD BRAF RBL2 TFG PTEN CD19 MTOR RAC1 IRS1 CTNNB1 RHEB TPR TSC2 FAR1 BCR POLK MB CDC37 MDM2 CCND1 RET PMC3118418__F1 Which FGF ligands are involved in lens induction? PROX1 FOXE3 SIX3 BMP4 OTX2 BMP7 PMC4930925__F4 Gene circuits for biomedical applications STAT3 IF2B1 LSR TNF CREB1 HRH2 PMC4750973__F5 Identification of Targets of CUG-BP, Elav-Like Family Member 1 (CELF1) Regulation in Embryonic Heart Muscle RPL35 REST RPL31 RPS2 RPL10A ELL RPLP1 RPL14 RPL7 ELF3 PMC9181451__F3 Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein–Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases DCAF15 RBM23 PMC9181451__F4 Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein–Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases RBX1 DDB1 CDK12 PMC5142754__F1 Targeting Inflammation in Cancer Prevention and Therapy STAT3 IGF1 CCL2 PMC5142754__F2 Targeting Inflammation in Cancer Prevention and Therapy HEL-S-62p TLR4 IRF3 PMC9181451__F1 Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein–Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases DDB1 IKZF1 CRBN PMC12025505__F2 Signaling Mechanism of Budding, Proliferation, and Tissue Regeneration in Cnidaria LATS1 LATS2 APC CTNNB1 PMC8579452__F3 IL-1B in atherosclerotic vascular calcification: From bench to bedside NLRP3 LRP5 LDLR LRP6 RAC1 IL1B PMC8035348__F3 Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma SOCS1 MUC13 RREB1 APC GSK3B EZH2 PTEN CTNNB1 PMC8035348__F4 Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma TH OS9 LDLRAD3 PTN HOXA9 EZH2 ARHA PMC5799771__F7 CK1Alpha-, 26 S proteasome-dependent turnover of FOXO tumour suppressors in RAS-mutant cancer cells FOXO4 MTOR NRF1 PMC7755484__F7 Proposed mechanism of AS-IV-induced melanogenesis AHR TYRP1 CTNNB1 PMC3500781__F1 Two different pathways could bypass DNA damage causing stalled replication forks RAD18 REV1 PCNA PMC7288008__F3 Pathophysiology of Ulcerative Colitis CXCL1 IRF4 FOXP3 CXCL10 CXCL8 GATA3 CXCL3 PMC9315664__F4 Advances in Crosstalk between Porcine Circoviruses and Host STAT3 CGAS CGA MAVS DNAJC7 SP1 STAT2 SIGIRR IRF3 IRF7 SOCS3 MYD88 KPNA3 EIF2A TRAF2 HDAC6 IL1B PMC4445694__F1 Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists’ arsenal STAT3 SP1 PMC7723564__F7 Primary mechanism of PRP improves chronic inflammatory pain STAT3 HMGB1 GFAP PMC6616296__F10 Proposed mechanism of the p75NTR as a mediator of synaptic changes during SD ROCK2 ARHA BDNF PMC4219936__F2 Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice FGF8A SPHK2 S1PR2 TLR4 CYP7A1 SPHK1 DKFZp666G145 IL1B PMC4537170__F1 Mammalian base excision repair and single-strand break repair pathways PNKP LIG1 MPG FEN1 PCNA NEIL1 POLE PMC4219936__F1 Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice CYP8B1 CYP7A1 PMC10418722__F12 Study on the Regulation Mechanism of Quality Deterioration Due to Chilling Stress and Dry Exposure during Anhydrous Storage and Transportation of Yesso Scallop Patinopecten yessoensis JUN OMP APP PMC5780146__F5 Differentially expressed genes (red) in the neonatal respiratory distress syndrome group compared with the control group in the TNF signaling pathway ITCH SELE CA13 MLKL CST2 CASP3 NOD2 IL6 TRAF3 TNF TRAF2 FADD PMC5780146__F6 Differentially expressed genes (red) in the neonatal respiratory distress syndrome group compared with the control group in the influenza A pathway IFNG CASP9 ADAR CUTA IRF9 PML IRF3 SOCS3 IL6 PMC8913936__F3 Proteomic Analysis Reveals a Novel Therapeutic Strategy Using Fludarabine for Steroid-Resistant Asthma Exacerbation STAT1 TAPBP CANX STAT2 IFIT3 TAP1 B2M TAP2 JAK1 TNF TYK2 PMC4461786__F4 Noncanonical Wnt5a signalling: a simplified view ROR2 RYK PMC3611005__F10 LKB1-SIK2/3-class IIa HDAC pathway as a novel signaling module SIK3 SIK2 CRTC2 HDAC5 HDAC7 PMC7864190__F2 Latent TGFB activation and the canonical TGFB signaling pathway SMAD2 PMC8814522__F4 Do Genetic Polymorphisms Affect Fetal Hemoglobin (HbF) Levels in Patients With Sickle Cell Anemia Treated With Hydroxyurea? A Systematic Review and Pathway Analysis MYB HBS1L KLF1 ARG1 BCL11A ARG2 PMC8167679__F1 Iron homeostasis and iron-mediated ROS in cancer CDC2 STAT3 SLC7A11 PMC8097341__F2 Various mechanisms underlying targeting of de novo DNMTs by histone methylation DNMT3B DNMT3L NSD2 SETD2 PMC4632302__F9 Diagram of signaling pathway for genistein-induced apoptosis in Bax and p53-independent manner CASP9 CASP3 APAF1 PMC8841732__F10 All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐KB Signaling Pathway MAVS TRAF6 IL1B PMC10980521__F7 Main pathways of reproductive candidate genes for follicular growth and ovulation in Tibetan sheep BMPR2 SMAD1 STAR DKFZp781O1323 SMAD4 IGFBP2 RGMB IGF1R LHCGR GNAS IGF1 DIPLA1 CYP11A1 BMP4 PMC7993417__F4 Phenotypic diversity and metabolic specialization of renal endothelial cells SIRT3 FAS LAT PMC7993417__F5 Phenotypic diversity and metabolic specialization of renal endothelial cells TFAM LPA KLF4 KLF2 HAS2 LPAR1 NOX4 SIRT1 PMC3769322__F3 Regulation of action cytoskeleton in LTLT-Ca MCF-7 cells HEL114 CRK VASP FYN CD14 RHO GNA13 PMC12179639__F1 Scientific diagram illustrating the mechanism of FGFR1 signaling, showing key pathways like PI3K-Akt-mTOR and RAS-RAF-MEK-MAPK for cell survival and proliferation JUN FGFR1 PTEN MTOR FOS PMC1855985__F1 Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4 MAPK11 MAPK13 ERBB4 EGFR RPS6KB2 BRAF KRAS MAPK6 FGFR2 MAPK3 ARAF ERBB3 HRAS MAP2K4 RPS6KB1 FGFR4 MAPK7 FGFR3 MAPK12 PMC6362409__F1 Microbiota and the intestinal barrier against infectious threats IFNG TH TLR4 TLR5 IL6 PMC12179639__F2 Interactions between the PD-1/programmed death-ligand 1 (PD-L1), fibroblast growth factor receptor 1 (FGFR1) pathways, and chemokines IFNG NEDD4 CX3CL1 FGFR1 CXCL10 FGF2 PMC9581278__F9 Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARAlpha-SREBPs pathway FGF8A TG NR1C1 CYP8B1 CYP7A1 FGFR4 CYP7B1 CYP27A1 PMC8517756__F2 Endothelial dysfunction and COVID-19 (Review) TNF ACE2 PMC6551999__F5 A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? STAT3 CYC1 CCND1 PMC7343815__F4 Autophagy as a modulator of cell death machinery ATG5 PMC6551999__F1 A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? DAO PMC2821201__F6 A diagrammatic model to summarize the role and subcellular localization of survivin and its splice variants in the regulation of apoptosis and control of mitosis in cancer cells CDC20 INCENP PMC10559578__F2 Production of IL-1B and its transduction signaling pathway GSDMD NLRP3 TXNIP IRAK1 TRAF6 IRAK4 MYD88 PMC3491906__F1 Distinct signaling pathways of synaptic and extrasynaptic NMDAR in neuron fate ATF3 TXNIP SIK2 BDNF PMC11846447__F4 Muscle protein regulation through the mTOR pathway RPS6 TSC2 IGF1 MTOR IRS1 PMC12191313__F3 Molecular Mechanisms of Epithelial–Mesenchymal Transition in Retinal Pigment Epithelial Cells: Implications for Age-Related Macular Degeneration (AMD) Progression APC TNF CTNNB1 PMC3528293__F1 Generalized overview of the extrinsic and intrinsic apoptosis pathways BAX TRADD TNF FADD PMC11171594__F1 TLR-mediated signaling HMGB1 TIRAP TLR9 IRAK1 TLR5 IRF3 IRF7 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 TLR10 PMC6705839__F3 System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells CDC2 DBF4 CDC20 PCNA SMAD2 SMC3 GSK3B SMAD4 MYT1 PLK1 ORC3 SKP2 ORC2 RAD21 CDK7 E2F4 CDC45 CDK2 MDM2 PMC8671568__F1 Neuroadaptations and TGFB Signaling: Emerging role in models of neuropsychiatric disorders SMAD1 ACVR2A DKFZp781O1323 ARHA RUNX2 TGFBR1 CTNNB1 MEF2D CAP2 SMURF1 TMEPAI DBN1 BMP4 PMC7495088__F9 PIgR regulation in CF lung CFTR IL17A PIGR PMC3865699__F1 Major mechanisms linking obesity with impaired muscle regeneration PCNA MTOR IL1B PMC4841026__F5 Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study JUN CREB3 GPX4 CFH KHSRP NR3C1 CTNNB1 TNFSF14 TFPI2 DDB2 SLC52A1 ARD1A FBRS ADAM9 EDNRB PAK6 PMC3500394__F1 FoxM1 and WntBeta-catenin Signaling in Glioma Stem Cells FOXM1 APC LRP5 LRP6 TCF4 CCND1 CTNNB1 PMC5794818__F2 T cell activation induces autocrine and intracellular complement activation that regulates T cell metabolic function and inflammasome formation NLRP3 HEL-S-62p ELL CTSL CD46 FOXP3 MTOR PMC8075059__F3 Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis EDAR TNLG7C PMC8424978__F7 Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway STAT3 SELE SELP PMC5856858__F1 KEGG Apoptosis pathway with highlighted dysregulated mRNAs and miRNAs HTRA2 CSA2 BAD CAD CASP2 TRADD MCL1 AIP ME1 SET PIR ATF4 HRK TRAF2 FADD PMC4727405__F8 Alternative NOTCH pathway representations NCOR2 LATS2 PAWR DLL4 NPM1 PRKCA NUMB PMC5541362__F2 Serotonin and serotonin transporters in the adrenal medulla: a potential hub for modulation of the sympathetic stress response TH SET PMC4727405__F4 Screenshot of CNV and splicing representation BAD MTOR PMC5797067__F1 Exon 3 mutations of CTNNB1 drive tumorigenesis: a review APC GSK3B AXIN1 TEF AXIN2 PMC6754810__F1 Activators and suppressors of OCT4 in cancer stem cells VEGFC SENP1 APC FOXC1 CTNNB1 PMC9310348__F1 Apoptosis regulation through protein–protein interactions BAX BAD FAS BOK BMF HRK APAF1 BIK FADD PMC6830904__F1 Intracellular NAD metabolism NNMT NRK AOX1 NMNAT1 NAMPT NMNAT2 NMNAT3 PMC10915323__F1 Leveraging molecular targeted drugs and immune checkpoint inhibitors treat advanced thyroid carcinoma to achieve thyroid carcinoma redifferentiation FLT3 EGF HGF GDNF EGFR TPO MTOR RET PMC7750537__F6 Crosstalk between the coagulation cascade and autophagy on tumor-associated endothelial cells FOXO1 ATG14 PMC7750537__F7 Crosstalk between coagulation and autophagy promotes cancer-associated thrombosis and metastasis TGFA PMC3688827__F6 Transcriptome Analysis Reveals Novel Entry Mechanisms and a Central Role of SRC in Host Defense during High Multiplicity Mycobacterial Infection THBS1 FAS EGR1 ABCC1 TGFB1 JUNB PLAUR MYC ITGAV CTNNB1 HMOX1 DNAJB2 NLRP3 KPNA3 CDKN1A DNAJB6 NFKB1 GCLC AHR SRC REL IL1B PMC7750537__F1 Coagulation and clotting factor signaling TFPI APC PLG PMC8350333__F8 Cross-talk among MEN1, p53 and Notch regulates the proliferation of pancreatic neuroendocrine tumor cells by modulating INSM1 expression and subcellular localization INSM1 MEN1 CCND1 HES1 PMC7750537__F2 Autophagic pathway ATG101 VWF ATG10 IL19 ATG3 ATG12 ATG14 BCL2 ATG5 PMC7750537__F5 Crosstalk of the coagulation cascade and autophagy pathway in cancer cells TF ATG12 IL1B PMC7567008__F3 Crosstalk between Toll-like-receptor (TLR) signaling and the Hippo pathway in Drosophila and mammalian cells ECSIT TBK1 IRF3 TRAF3 TRAF6 IRAK4 MYD88 PMC4338943__F1 Retinoid signaling (RA) signaling pathway CYP26B1 CYP26C1 HEL-S-53e LRAT RBP4 HEL-S-4 ALDH1A3 DHRS9 CRABP2 CRABP1 DHRS4 RDH10 ALDH1A2 ALDH8A1 CYP26A1 PMC8076900__F1 Control of T Cell Metabolism by Cytokines and Hormones IL21R IL7R SLC7A5 MTOR PMC5056151__F2 Transport proteins in Alzheimer’s disease ABCC1 APOE ABCG2 ABCA1 ABCB1 PMC10216079__F3 Main signaling pathway in rheumatoid arthritis APC MTOR TNF CTNNB1 PMC5666796__F9 Schematic model of possible signalling events involved in the upregulation of TGFB1 expression by LTBP-2 LTBP2 F2 F3 PMC4253516__F7 Transforming growth factorB (TGFB) and the canonical Smad pathway negatively regulate CD1d-mediated antigen presentation SMAD2 SMAD4 PMC6130320__F4 MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics CD44 CD74 MIF PMC3830618__F2 Homeostatic plasticity at the Drosophila neuromuscular junction CDC42 SNAP25 PMC12010972__F4 Targeted therapy for osteoporosis SOST LRP5 LRP6 WIF1 CTNNB1 PMC12010972__F2 Inhibition of Wnt/Beta-catenin signaling pathway by Wnt signaling pathway inhibitors SOST DKK1 LRP5 RUNX2 WIF1 PMC12010972__F3 Wnt signaling pathway inhibitors SOST DKK1 APC GSK3B LRP5 LRP6 RUNX2 WIF1 CTNNB1 PMC12010972__F1 Regulatory mechanisms of the Wnt signaling pathway JUN APC ROR2 LRP5 LRP6 ARHA RUNX2 CTNNB1 PMC7567008__F1 Tumor-cell-intrinsic roles of Yap/Taz in regulating tumor immunity LATS1 LATS2 PMC7471657__F3 Gene ontology terms and KEGG pathways KRT20 CD3D MS4A1 PDCD1 PTPRC SNCA IL6 FOXP3 CD8A CD3G CD68 CD3E PMC9751411__F2 Interferon and interferon-stimulated genes in HBV treatment STAT1 STAT2 IFNAR2 IRF9 IFNAR1 PMC5591558__F3 EGFR cell signaling and lncRNAs relationship in lung cancer therapy resistance EGFR PTEN IGF1R GRB2 MTOR IRS1 PMC4649479__F1 Phosphatidylethanolamine and phosphatidylcholine biosynthesis by the Kennedy pathway occurs at different sites in Trypanosoma brucei PC PMC8835863__F1 Apoptosis during ZIKA Virus Infection: Too Soon or Too Late? ATF4 XBP1 FADD PMC5698512__F1 IL-6 signaling pathways ADAM17 MTOR CCND1 PMC9453844__F6 Identification of potential miRNA-mRNA regulatory network and the key miRNAs in intramuscular and subcutaneous adipose WNT10B PRICKLE3 STAR WNT16 FOSL1 NR1C2 RSPO3 WNT2B PMC11594159__F1 Redrawn from WSP268, the version of the Notch signaling pathway depicted on Wikipedia https://www DVL1 DTX1 DTX2 DTX3 DTX4 NUMB CTBP2 MAML3 APH1B CTBP1 JAG2 LFNG MFNG NOTCH3 DLL3 HDAC2 HES1 NOTCH1 HES5 DLL4 DTX3L DVL2 NOTCH2 TNF HDAC1 NCOR2 MAML1 PSEN2 DVL3 CREBBP PMC122866__F4 The pathway of PUFA synthesis in C FAT4 FAT1 FAT2 FAT3 PMC6770240__F1 Overview of an acute myeloid leukemia cell’s metabolism GLS HEL-S-26 PMC7552539__F5 Simplified examples of the roles that different classes of ceRNAs play in HCC oncogenesis USP22 ASAP1 ARHA SIRT1 PMC2905036__F3 Schematic diagram depicting the molecular mechanisms by which inflammation activates hepcidin transcription in the liver STAT3 BMP6 SMAD1 DKFZp781O1323 SMAD4 IL6 HFE2 PMC2905036__F2 Schematic diagram depicting the proposed role of bone morphogenetic protein (BMP) signaling pathway, HJV, HFE, and TFR2 in iron sensing and hepcidin regulation in the liver BMP6 SMAD1 TFR2 DKFZp781O1323 SMAD4 HFE TMPRSS6 HFE2 PMC8532063__F1 Current Diagnosis and Management of Primary Chylomicronemia LPL LMF1 GPIHBP1 PMC11641621__F3 Schematics describing the role of particular small-molecule protein kinases and their inhibitors in PAH microenvironment, including such molecular hallmarks as inflammation, apoptosis, proliferation, or mitochondrial function FLT3 ALK EGFR DDR2 MTOR PMC3334602__F7 Cordycepin analogues and the C PNP NT5E ADK ADA PMC5036407__F6 Illustration showing the mechanism by which NDRG1 mediates activation of the Wnt signaling pathway TLE2 APC CTNNB1 PMC5609400__F3 The Shh, TGFB/BMP, and Wnt morphogenic signaling pathways SUFU APC PTCH1 GSK3B LRP5 SHH LRP6 SMO RHO DAAM1 CTNNB1 PMC5029616__F1 Altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters GSK3B MMP2 ARHA MMP9 PMC5029616__F2 Altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters TFAM SP1 MDM2 PMC3168677__F2 MicroRNAs in Rheumatoid Arthritis TLR4 IRAK1 IL6 TRAF6 IRAK4 IL1B MYD88 PMC9393262__F1 Th2A cells: The pathogenic players in allergic diseases ZAP70 COX1 APC IL33 TRAF6 MYD88 PMC9698307__F1 Emerging Direct Targeting Beta-Catenin Agents BCL9 APC LRP5 LRP6 CTNNB1 PMC5773404__F2 Synaptically Localized Transcriptional Regulators in Memory Formation NPAS4 ARC BDNF CRTC1 PMC6895530__F6 Working model BAX BCL2 MTOR PMC8696218__F8 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells TGFBR2 SNAI1 SMAD2 SMAD4 TWIST1 TGFBR1 PMC8696218__F6 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells CPT2 APOA5 PMC8696218__F7 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells EGFR SOX2 ERBB2 IGF1R MTOR MYC PMC8696218__F4 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells CCL19 LTBR RELB BMP2 TERT MMP9 MYC KRAS TNF CCND1 PMC4617547__F1 Summary of unfolded protein response and endoplasmic reticulum stress signaling pathways STAT3 JUN PPP1R15A EIF2AK1 ATF4 ATF2 EIF2A PPP1R15B XBP1 TRAF2 PMC8696218__F5 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells STAT3 MMP2 MYC PMC2779759__F7 Schematic model illustrating how Jun proteins regulate the TIMP-3, TACE, and TNFA pathway: Jun proteins transcriptionally activate TIMP-3 expression, which is responsible for TACE inhibition TIMP3 JUNB TNF PMC8696218__F2 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells SOX9 DLL4 JAG2 MYC FURIN DLL3 PMC8696218__F3 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells SNAI1 SMO CCNB1 MYC PMC2528859__F2 The UPR sensors PERK, IRE1A, and ATF6 control mRNA translation and transcriptional induction of UPR-regulated genes ATF4 EIF2A IAPP PMC8696218__F1 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells APC GSK3B AXIN1 MYC TNIK GPR49 CTNNB1 PMC9495000__F6 Transcriptome Analyses Provide Insights into the Auditory Function in Trachemys scripta elegans GABRG2 KCNJ6 SLC38A1 GABBR2 GABRR3 PMC9520664__F1 V-Set and immunoglobulin domain containing (VSIG) proteins as emerging immune checkpoint targets for cancer immunotherapy NLRP3 HEL-S-62p PDK2 VSIG4 PMC8564058__F9 An ATX-LPA6-GA13-ROCK axis shapes and maintains caudal vein plexus in zebrafish LPA ARHA CTNNB1 PMC3310050__F12 Folate Decorated Dual Drug Loaded Nanoparticle: Role of Curcumin in Enhancing Therapeutic Potential of Nutlin-3a by Reversing Multidrug Resistance BAX BCL2 MDM2 PMC7249327__F6 At the top of the signalling pathway, the critical Arpp19 dephosphorylation at S109 by PP2A-B55D CDC2 ARPP19 MOS PMC5929433__F1 Ceramide species are elevated in human breast cancer and are associated with less aggressiveness UGCG CERK ORMDL1 GBA2 SGPL1 SGMS1 SGMS2 SMPD1 SMPD2 ASAH2 SMPD4 ORMDL2 ORMDL3 PMC4162460__F8 Schematic for reprogramming of EBV-induced glucose metabolism HK2 GSK3B MYC PMC6441621__F1 miR-223 regulates the canonical NFKB pathway and other pathways related to cancer STAT3 MAFB IRAK1 IGF1R TRAF6 IRAK4 MEF2C MYD88 STAT1 MAP3K7IP1 NLRP3 PKNOX1 FOXO1 NFAT5 REL PMC8760138__F3 Chloroplast ROS and stress signaling LOX FECH PMC2940478__F3 Web-accessible GnRHR pathway navigator REST CDA PMC8698532__F2 Targeting Inflammasome Activation in COVID-19: Delivery of RNA Interference-Based Therapeutic Molecules NLRP3 TLR4 SPRY1 PMC11995514__F5 Core mechanism of necroptosis and related kinases affect the signaling pathway RIPK3 ZBP1 TRADD MLKL RIPK1 TRAF2 FADD PMC9326668__F1 Polyamines and Their Metabolism: From the Maintenance of Physiological Homeostasis to the Mediation of Disease SLC3A2 SMS ATP13A3 SRM SLC22A3 SMOX SLC22A2 PAOX ARG1 SLC22A1 SLC12A8 PMC11995514__F6 Core mechanism of ferroptosis and related kinases affect the signaling pathway SIRT3 SLC40A1 AIFM2 GPX4 FGFR4 TCF4 SLC7A11 DDR2 SRC CTNNB1 PMC11995514__F3 Core mechanism of pyrotosis and related kinases affect the signaling pathway STAT3 NLRP1 GSDMD TRADD NLRP3 EGFR GSDMC GZMA GSDMB DFNA5 PMC11995514__F4 Core mechanism of autophagy and related kinases affect the signaling pathway ATG101 STAT3 ATG10 SYK PIM2 ATG3 ATG12 ULK1 EGFR BMX PLK1 ATG5 PMC3519956__F6 Schematic model depicting how HMW isoforms regulate bone formation FGFR1 FGF2 FGF23 PMC11995514__F2 Core mechanism of apoptosis and related kinases affect the signaling pathway STAT3 BAX EGFR MTOR PMC5313453__F2 Figure illustrating five pathways putatively causing pathological remodelling in ACM: 1) Deficits in EB-1 ID protein trafficking provoke disturbance of the ID morphology PLN GSK3B CTNNB1 PMC3928173__F4 Epigenetic loss of the PIWI/piRNA machinery in human testicular tumorigenesis PIWIL2 TDRD1 PIWIL1 PIWIL4 PMC4889278__F6 Upon tumor progression E-cadherin downregulation leads to an increase of the proportion of CSCs and acquisition of the ability to form secondary foci of tumor growth SOX2 CTNNB1 PMC2729687__F2 Immunological synapse or the interface between an antigen presenting cell and a T-cell PTPN22 APC CTLA4 FOXP3 PMC9563579__F1 Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation IRF3 TNF PMC3185522__F3 HCV induces the over-expression of PP2Ac via an ER stress response pathway PRMT1 STAT1 IFNAR2 JAK1 TYK2 PMC3865984__F1 Autophagy Pathway ATG10 ATG3 ATG12 ATG5 PMC3865984__F2 Molecular regulation of autophagy ATG101 ULK1 RB1CC1 MTOR PMC9127500__F9 Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non–Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway CDK2 ATF4 MTOR PMC11789495__F5 MTORC1 signaling pathway extensively controls cellular metabolism MTHFD2 CAD FOXK1 HK2 ULK1 HIF1A HEL-S-70p HEL-S-51e HEL-S-68p PHGDH HEL-S-49 PGM2 TFEB MTHFD1L SRPK2 ENO1 PSAT1 ATF4 HEL-S-87p PFAS PSPH PMC5291092__F8 Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox ALB KEAP1 NQO1 GCLC PMC7364497__F2 Crosstalk between key signal pathways during prostatic budding NKX3-1 CTNNB1 PMC7272660__F5 Genes mapped to KEGG pathways by pathway analysis EMP1 MPL PMC4284387__F2 MiR-124 and miR-9/9* engage in complex regulatory circuits activating a neuronal gene expression program REST PTBP1 HES1 PMC11617408__F6 Activin and BMP signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC4107712__F1 Illustration of the PI3K/Akt/mTOR pathway RHEB TSC2 TSC1 EGFR PTEN DEPTOR PMC11617408__F5 Apoptosis: Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) initiates cell death through two mechanisms: direct caspase activation or indirect activation via the release of apoptogenic factors from mitochondria FAS TRADD TNF TRAF2 FADD PMC6073766__F1 Major downstream signaling pathway of mTORC1 and mTORC2 MTHFD2 ULK1 TFEB DEPTOR PMC7317437__F5 Proposed schematic diagram of signalling pathways for doxorubicin‐induced muscle atrophy GDF8 IGF1 SMAD2 BNIP3 MTOR IRS1 PMC2701885__F2 Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence SOCS1 TBK1 TLR3 IFNAR2 IFNAR1 IRF3 IRF7 SOCS3 JAK1 TYK2 PMC11214400__F6 Inflammatory loop involving Staphylococcus aureus, IL-36G, and cathepsin S drives immunity disorders in familial acne inversa keratinocytes KLF4 IFNG PMC11549404__F9 Molecular mechanisms underlying FNDC4-mediated protection against cardiac I/R injury HIF1A FNDC4 PMC7393197__F3 Antitumour peptide based on a protein derived from the horseshoe crab: CIGB‐552 a promising candidate for cancer therapy BAX CASP9 CASP8 RAB5A CASP3 COMMD1 HEL-S-44 PMC2861543__F6 Differential role for endocytosis in receptor-dependent Nox1 generation of ROS and activation of cellular signalling EGFR ATF1 PMC7649120__F6 Scheme of possible pathways by which liposomes can “hit” PIM cells via C activation; example for the case of PEGylated liposomal doxorubicin (Doxil) and other PEGylated NPs ATR HEL-S-62p CR2 CR1 CP PMC4583851__F5 The differentially expressed profiles MAX ECSIT SYK LTA FAS TRADD LAT BLNK TRAF3 TRAF6 LTB BCR COX2 NLK TRAF2 LBP PMC8256842__F8 13-Gene Metabolic Prognostic Signature Is Associated With Clinical and Immune Features in Stomach Adenocarcinoma CGA LIF SHE INS PMC8473087__F5 COVID-19: Mechanistic Model of the African Paradox Supports the Central Role of the NFKB Pathway TMPRSS2 IL10 TLR3 IL13 TLR4 TLR8 IL4 IRF7 TLR7 VCAM1 CXCL10 ACE2 PMC3588179__F2 T-cell immune regulation by IDO1 HEL-S-92n PDC CD19 PMC6831453__F1 Multiple immunosuppressive mechanisms coexist in tumor microenvironment CD80 HMGB1 CXCL12 CCR5 CXCL1 CCR2 TLR9 ARG1 MTOR VEGFA CCL2 TDO2 CXCR1 TLR3 COX2 TLR4 TLR8 AHR TLR7 CXCR4 PMC3588179__F4 The mechanism of IDO1 regulation on viral infectious diseases IDO1 PDC MTOR PMC4673281__F6 Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic LTBP1 THBS1 LEP ROCK2 APC SMAD4 NODAL ARHA PITX2 BAMBI IFNG RBX1 SOST FST CER1 SKP1 NLK PMC11518755__F1 Molecular alterations of RAI-RTCs ALK PAX8 BRAF ARID2 PTEN MTOR RET PMC8070110__F2 Schematic diagram of the interconnection between EMT and TRF1/2 CDH2 SMAD2 SMAD4 MMP2 TERT MDM2 POT1 TWIST1 PMC11518755__F2 NIS expression TSHR SMAD2 PAX8 SMAD4 TTF1 PMC4516463__F1 Signalling pathways involved in skeletal muscle remodelling and atrophy following disuse BAX IGF1 C2 SMAD2 MTOR IRS1 PMC8848474__F1 Antitumor activity of the dual PI3K/mTOR inhibitor gedatolisib and the involvement of ABCB1 in gedatolisib resistance in canine tumor cells TSC2 FOXO3A PTEN PMC3811055__F2 mTOR pathway CD80 APC IL2 MTOR PMC3594971__F3 c-jun N-terminal kinase (JNK) pathway in postmitotic migrating neurons DCX MAP1B RAC1 PMC11989508__F3 In PD, the molecular mechanism of ERS involves the interaction of multiple factors THBS1 LRRK2 EIF2A FAM171A2 PMC11989508__F4 In PD, ERS forms a complex vicious cycle with mitochondrial dysfunction, oxidative stress, and neuroinflammation, collectively driving disease progression BAX HMGB1 LRRK2 TLR4 PMC11989508__F1 ER is a membranous network structure in eukaryotic cells, divided into the RER and the SER ATF4 EIF2A PMC4042834__F4 An example of a KEGG pathway containing genes involved in multiple processes MAX HEL-S-31 CDC42 CHP2 EGF FAS RAF1 EGFR EVI1 BRAF ATF2 MYC TRAF6 MEF2C NGF RASA2 NF1 NRAS ATF4 PPM1B ECSIT MAP4K3 JUN TNFSF6 CD14 TNF FOS MAP3K7IP1 MAP3K1 MOS RELA CASP3 HEL-S-102 DDIT3 NLK GRB2 TRAF2 PMC3847167__F4 Lines/LINS plays a putative dual role in WNT canonical pathway WNT1 CTNNB1 PMC4648177__F3 IG20pa and MADD as antagonists in the TRAIL-induced apoptotic pathway MADD FADD PMC7020748__F2 Key pathways most frequently mutated in MPM all contribute to global downregulation of microRNA levels LATS2 BAP1 BCL2 EZH2 MDM2 NF2 MYC DROSHA PMC5500790__F1 Wnt signaling pathways APC RYK RHO PMC6069411__F1 Canonical Hh signaling pathway SUFU GSK3B SMO PMC17314__F1 An integrated view of the biology of Halobacterium NRC-1 SRP19 SRP54 SRI CD2 PMC6069411__F2 Canonical Wnt/Beta-catenin signaling pathway [,,,,,,,] CD44 BCL9 MMP7 IGF2BP1 APC MAL SOX2 GSK3B PMC11434717__F3 Terpene trilactone biosynthetic pathway IPP MVD MVK PMC7818012__F2 Mass spectrometry-based protein‒protein interaction techniques and their applications in studies of DNA damage repair POLD3 RFC4 RFC1 RFC2 PMS2 OGG1 PNKP RPA3 POLD4 POLE POLD2 PALB2 MSH6 USP28 RAD52 RAD50 CETN2 MSH2 RAD51 POLE2 CHAF1B MSH3 CHAF1A H2AX HMCES UIMC1 NBN NUDT16L1 PRIM2 ABRAXAS1 PRIM1 MDC1 RBBP8 XPC TP53BP1 PMS1 DDB2 MSH4 NEDD8 BARD1 XRCC5 HEL-S-71 RBX1 MLH3 DDB1 UBE2H POLE4 LIG1 POLA1 MRE11A POLA2 BRCA1 APEX1 UVSSA POLE3 RPA4 ERCC5 ERCC1 BRIP1 ERCC2 PCNA BRCA2 XAB2 BLM CCNH DNA2 CDK7 POLG MNAT1 ATM POLR2A TOP2A WRN HMGN1 RPA1 PARP1 POLK EP300 RFC3 BRCC3 PMC8962344__F2 Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery CAD HEL-S-133P HEL-S-68p AK3 EPO BCL2 VHL PMC8221351__F9 Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer’s disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/Beta-catenin pathway WNT3A BACE1 CTNNB1 PMC7527296__F1 IL-6-STAT3 signaling is a potential therapeutic target for COVID-19 mediated by cytokine storm TMPRSS2 STAT3 HBEGF ADAM17 EGFR ACE2 PMC8134730__F7 Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice LIMK1 MTOR BDNF RAC1 PMC6539991__F4 Gene-Pathway network BAD FYN CDC20 PCNA BCL2 VEGFA PMC6539991__F5 Sub-molecular network of CC, EC and VC CDC2 IGF1 BCL2 CCNA2 VEGFA FGF2 PMC6539991__F3 Pathway networks MIA RAN PAH PMC5952219__F2 TLR4 signaling pathway TBK1 HMGB1 MAL IRAK1 RIPK1 IRF3 IRAK2 IRF7 TRAF6 TNLG7C MYD88 PMC2776748__F1 A, Schematic diagram showing intra-cellular functions of the Bcl family of proteins BAX BAD TNF CXCL8 APAF1 PMC10138871__F7 NpPP2-B10, an F-Box-Nictaba Gene, Promotes Plant Growth and Resistance to Black Shank Disease Incited by Phytophthora nicotianae in Nicotiana tabacum SKP1 PMC11203709__F3 VHL-mediated signaling/regulatory pathways in ccRCC with respect to PAX involvement PAX2 SMAD2 APC GSK3B PAX8 SEMA6A MTOR SMURF2 MYC CCND1 CTNNB1 VHL PMC4110518__F1 Cellular origin of thyroid carcinomas is shown PAX8 BRAF PMC8536509__F2 MTORC1 by amino acids in mammalian cells: A general picture of recent advances PRR5 RHEB MLST8 RICTOR IGF1 ULK1 TFEB MTOR DEPTOR IRS1 PMC9495330__F13 Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity TLR4 TRAF6 MYD88 PMC7817106__F7 Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation SOX2 SOX10 HDAC2 ADA PMC4562270__F4 Proteomic approaches for profiling negative fertility markers in inferior boar spermatozoa STAT3 TGFB1 AVPR2 GPX4 CYCS GSK3B INS TUBA1B MAPK8 MYC MAPK3 IFNG HSPD1 APP IL1B MAPK1 ACTN1 BAX SP1 STAT2 PTGS2 IL6 TNF UQCRC1 SDHA CEBPA GSTM3 HEL-S-162eP RELA CASP3 BCL2 GYPC ACRBP VCAM1 EMB RAB2A PS1TP5BP1 ACR AVP PMC11666154__F5 LTBP3 combined with SLC (TGFB and LAP via disulfide bonds) significantly strengthen the bioavailability of TGFB RBP1 SMAD2 SMAD4 pp6425 PMC7559172__F7 Wnt signaling pathway enriched in KEGG SIAH1 ROCK2 APC SMAD4 RYK ARHA CTNNB1 BAMBI SOST INVS STOM NOTUM CER1 SKP1 NLK DAAM1 PMC2131730__F4 LPS signals the TLR4 pathway on an APC (i.e., monocyte or dendritic cell) TIRAP TLR4 CD14 LBP MYD88 PMC3278537__F2 Signaling Pathways Underlying the Pathophysiology and Treatment of Depression: Novel Mechanisms for Rapid-Acting Agents PTEN GRB2 BDNF PMC9678415__F7 Systematic review of the biological mediators of fat taste and smell STIM1 TRPM5 SRC CALHM1 PMC6598280__F2 Paracrine effects of the ASC secretome and involved pathways CRP PDGFD IGF1 IL2 PMC9030409__F4 Personalized Diagnosis in Differentiated Thyroid Cancers by Molecular and Functional Imaging Biomarkers: Present and Future SLC5A5 BRD4 PDGFRA BRAF ERBB2 MTOR NOX4 PMC3654375__F2A Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning CDK5 FYN ARHA RAC1 PMC12041035__F3 Exosomes mediate crosstalk between kidney cells TEC HK2 TNF PMC8798716__F9 Identifying the potential regulators of neutrophils recruitment in hepatocellular carcinoma using bioinformatics method CAD LAT RHO OTP ADA PMC12041035__F5 Exosomes mediate cell regeneration, repair, and fibrosis SOCS1 HK2 PMC7196612__F2 Virulence factors of Fusobacterium (F.) nucleatum TIGIT ULK1 MYD88 PMC7196612__F3 Oncogenic properties of Bacteroides (B.) fragilis STAT3 CTNNB1 PMC4269881__F6 EHEC-host interactome reveals novel targets for the translocated intimin receptor CDC42 UBE3A METTL21A NCALD SLC34A1 TRADD HPCAL1 DTX2 HPCAL4 RBCK1 IRAK1 TRAF6 IRAK4 IKBKG MYD88 PNP TUBA4A TLR4 UBC CD14 ARHA TUBB MAP3K7IP1 HEL-S-162eP TRAF5 BAIAP2 TRAF2 PMC7232345__F7 Proposed model for OAS2 regulation of ZIKV replication and IFN pathway STAT1 STAT2 IRF9 IFIT2 IRF3 IRF7 OAS2 PMC12041035__F1 Biogenesis, secretion, and structure of exosomes CD81 CD9 CD82 CD63 PMC4123081__F1 Simplified schematic representation of the extrinsic and the intrinsic (mitochondrial) pathways of apoptosis and necroptosis BAX TRADD TRAF2 FADD PMC4133905__F2 Normal, physiological insulin signaling transduction (left) and an altered pathway following insulin withdrawal (right) in adult hippocampal neural stem cells TSC2 TSC1 MTOR PMC4123081__F4 Ingenuity Pathway Analysis of the miRNAs identified as involved in regulation of cardiomyocyte apoptosis (see ) FUT6 DOCK6 SPRR3 TMPRSS4 PLAC1 AFM FOXO6 PROKR1 FAM168A DUOXA2 SLC16A9 IFNG IP6K3 OSBPL7 BTN1A1 SEMA6D INSRR TRPV2 INPP4B CLEC4A RAB36 SCGB3A1 TINAG ANGPTL1 TK1 IGF1 UXS1 SIRT1 PMC11211753__F6 Possible mechanisms of action of TR for altering ECM turnover SMAD2 PLG SMAD4 PMC8430761__F1 Multiple Leptin Signalling Pathways in the Control of Metabolism and Fertility: A Means to Different Ends? STAT3 IRS4 PTEN MTOR SOCS3 CRTC1 KISS1 INSR POMC CARTPT NPY GRB2 AgRP SH2B1 PMC6925433__F4 The insulin signal pathway RHEB TSC2 BAD FAS CBL INSR GRB2 MTOR INS EIF4E PMC8062261__F12 TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NFKB activation SHARPIN COIL IRAK1 TRAF6 IRAK4 MYD88 PMC3271076__F8 Novel YY1-miR-1 Regulatory Circuit in Skeletal Myogenesis Revealed by Genome-Wide Prediction of YY1-miRNA Network CDC42 POLA1 CCND2 YY1 ARHA PAX7 HAND2 PMC3654375__F1A Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning SEMA4D ERBB2 RRAS ARHA RND1 RAC1 PMC7605384__F6 Network of the tRF-mRNA-pathway constructed with 7 selected tRFs (5 were upregulated and, 2 were downregulated) and their target gene CXCR3 STAT3 CACNG3 SOS1 PXN PRKCZ PPP3CA FZD3 PORCN FGFR1 PRKCA TAOK1 VAV3 FLNB XCL1 PRKACG PAK1 PLCB1 CXCR5 ADCY1 BDNF DAAM1 RASGRF1 CCL22 CACNG8 CACNA2D4 STK4 APC2 DUSP2 MEF2C TGFBR1 DUSP3 GNB1 CX3CR1 CX3CL1 PLCB3 MAP2K3 PPP2R5D DUSP7 CACNB1 PRICKLE2 CACNG7 GPC4 NFATC4 GNG13 GNB5 LAMTOR3 PLA2G12A DAAM2 MAP3K7IP1 CTNNBIP1 VANGL1 RELA DVL3 CREBBP FGFR3 CAMK2G PMC4142057__F1 Activation of NFKB signaling through canonical and alternative pathways LTB CD40 RELB TNF PMC4142057__F2 NFKB and p53 antagonises each others activity ATR MDM2 PMC6350063__F1 Understanding the Role of Antiviral Cytokines and Chemokines on Neural Stem/Progenitor Cell Activity and Survival STAT3 LIF CASP3 CCND1 HES1 PMC10605306__F1 Interleukin-33 signaling pathway IL33 TRAF6 IRAK4 MYD88 PMC4059820__F2 Signaling through T1R2/T1R3 in type II cells of taste buds, in the gut and in the B cells of the pancreas TRPM5 PLCB2 PMC2632675__F3 Cell cycle pathways in S MBP TEN1 H1-1 DAO PMC4517052__F1 Main metabolic pathway in the bioactivation and DNA adduct formation of BaP in lung CYP1B1 CYP1A1 MPO PMC4074570__F3 Regulation of receptor-mediated endocytosis by CRL pathways IFNE RBX1 IFNAR1 SKP1 PMC3900881__F3 Sugar for the brain: the role of glucose in physiological and pathological brain function HEL-S-162eP TIGAR PMC5840209__F3 Apoptosis signaling pathways BAX BMP6 BAD MCL1 FSHR BIK PMC5418249__F1 PD-1:PD-L1 mechanisms between T-cells and tumor cells ZAP70 APC PTEN MTOR PMC11904106__F1 Targeting intracellular autophagic process for the treatment of post‐stroke ischemia/reperfusion injury RHEB EGF TSC2 TSC1 PMC3904431__F3 Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges CDC42 HOXD10 HOXA1 CDK6 SP1 MCL1 MMP2 KIT BCL2 PTEN CEBPB SOX4 PMC6137199__F6 Predicted target genes of miR-125a-5p and let-7e-5p in the Inflammatory response molecular network KLF4 KLF3 PPARG SYK ABCC1 OSM JAK3 CCR2 F7 SMAD4 SULF2 ITGAX MAPK14 PTPRO OSMR IRAK3 IL2 MAPK12 ABCG2 PTGFR CYLD CD6 CRP ICAM2 IL10 CXCL13 SOCS4 TICAM2 OSCAR KIT ULBP1 PTGS2 CTLA4 IL10RA VEGFA TNF FOS ICOS ITGAM TSLP GALNS FES FPR2 TRAF1 PMC7377858__F6 circRNA-miRNA-mRNA network CORT FIGN TOPORS APC RERG SPOPL PMC3544775__F3 Laminin-211 in skeletal muscle function BAX BAD GRB2 PMC5543893__F8 Involvement of KRT23 in the cell cycle: G1/S check point pathway CDKN1A SMAD4 DACH1 KRT23 CEBPB PMC7835019__F9 Proposed model depicting the involvement of the eNOS/cGMP/PKG pathway in PF activation FBXW7 KIT MTOR PMC9071930__F7 Palovarotene Can Attenuate Heterotopic Ossification Induced by Tendon Stem Cells by Downregulating the Synergistic Effects of Smad and NFKB Signaling Pathway following Stimulation of the Inflammatory Microenvironment SOX9 MMP9 RUNX2 ID1 PMC3411066__F6 Formation and function of 16:1-PI in the signaling of the lipokine 16:1 in Swiss 3T3 cells LPA HMFN0839 FAS GPAT4 GPAT2 PC PMC5481559__F14 Proposed model for persistent fibrosis in mice after lung injury HAS2 HYAL3 NOX4 PMC9004589__F6 Astrocytes: The Housekeepers and Guardians of the CNS TRPA1 TRPC4 TRPC1 TRPC5 PMC8363454__F6 Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NFKB Signaling Pathway TIRAP PHLPP2 RAC1 PMC9095844__F1 Thioredoxin-1: A Promising Target for the Treatment of Allergic Diseases SYK BTK CCR3 LYN MIF PMC4526652__F7 Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue PMC9563430__F9 PRELP Regulates Cell–Cell Adhesion and EMT and Inhibits Retinoblastoma Progression CDC42 AURKA SMAD1 BAD DKFZp781O1323 CYCS BBC3 MYC CTNNB1 RB1 FANCD2 CDKN2C ATM MDM2 SRC RALBP1 BAX JUN LAMTOR3 APC TNFSF6 NBN BCL2L11 RBPJ FOS RBL1 CBL PRKDC SUFU CASP3 MAP3K7 CREBBP EP300 HP DIABLO FADD PMC9563430__F5 PRELP Regulates Cell–Cell Adhesion and EMT and Inhibits Retinoblastoma Progression MAX AURKA DVL1 BAX BAD BBC3 CCNC FOS RB1 PRKDC SUFU BCL2 ATM MAP3K7 NLK SRC FADD PMC9247880__F2 Molecular Genetics and Targeted Therapies for Paediatric High-grade Glioma EGFR BRAF PTEN MTOR MYC MDM4 TSC2 TSC1 CDK6 NF1 PDGFRA ERBB2 CDK2 MDM2 CDK4 PMC3824005__F3 Canonical and noncanonical functions of the apoptotic machinery BAX NMNAT2 PMC3314482__F1 Chk’ing p53-deficient breast cancers ATR NOG CDK2 ATM PMC3824005__F1 Core components of the apoptotic machinery BAX DCC TNF PMC4095906__F3 TLR and BCR signaling and integration in CSR and antibody responses CD40 RELB TAB3 MAL TLR9 MTOR TRAF3 TRAF6 IRAK4 HOXC4 MYD88 BCL10 BCR PLCG2 TLR4 TRAF2 AID PMC3656649__F1 ENDOCRINE RESISTANCE IN BREAST CANCER SP1 EGFR SRC PMC8493254__F5 Proteome Modulation in Peripheral Blood Mononuclear Cells of Peste des Petits Ruminants Vaccinated Goats and Sheep IFIT1 IFIT3 IRF3 DHX58 NCR3 TRAF4 IRF6 NGF RTP4 ZBP1 TRIM25 TLR3 TLR4 MX1 ISG15 DLX3 PMC8493254__F6 Proteome Modulation in Peripheral Blood Mononuclear Cells of Peste des Petits Ruminants Vaccinated Goats and Sheep STAT2 IRF9 SOCS4 IFIT1 GAS2 IRF3 IRF7 RSAD2 SOCS7 STAT1 ZC3HAV1 NFKBID ZBP1 TRIM25 IRF2 IFNAR1 ISG15 PMC12192923__F2 The cGAS-STING pathway in health and cancer therapy TBK1 CGAS IRF3 PMC7998005__F8 miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease FOXD3 ADD1 ROCK2 PMC7554708__F3 Representative pathways involved in the metabolism of diacylglycerol (DAG) and phosphatidic acid (PA) LPA PC LPP PMC7282166__F1 Protein-protein network of the 186 exposure genes RAN SLPI OSM ADM CLU SYT2 NAMPT GNAL GYPC DUSP2 PMC9304296__F2 DNA damage response proteins in canine cancer as potential research targets in comparative oncology TOPBP1 ATR RAD51 BRCA1 BRCA2 PALB2 PMC6819196__F8 HIPPO SIGNALING CONTROLS NLRP3 ACTIVATION AND GOVERNS IMMUNOREGULATION OF MESENCHYMAL STEM CELLS IN MOUSE LIVER INJURY LATS1 LATS2 NLRP3 MSC XBP1 CTNNB1 PMC9304296__F4 DNA damage response proteins in canine cancer as potential research targets in comparative oncology TOPBP1 ATR ATRIP MDC1 PMC5460284__F4 Network model describing association of hyperactivated mTOR signaling with developmental and morphological defects in forebrains TSC1 MVD PMC11663879__F4 Molecular mechanism and RNA modification with their functions in Macrophage STAT1 WTAP YTHDF2 PMC6121658__F1 MDSCs expansion is regulated by several factors in vivo microenvironment STAT3 IL33 AHR MTOR PMC6997465__F1 Immune system and nociceptor activation NGF TRPA1 NAV1 TRPV1 MTOR TNF PMC3757395__F1 Scheme of miRNA processing pathway DROSHA PMC8389290__F7 Uncovering Mechanisms of Zanthoxylum piperitum Fruits for the Alleviation of Rheumatoid Arthritis Based on Network Pharmacology MAX EGF UBC AQP7 MAK UCP1 HEL-S-28 NPB PLTP TNF DAO PMC9362873__F1 LILRB4, an immune checkpoint on myeloid cells TH BCR LILRB2 APOE LILRB4 ARG1 PMC10385954__F13 Putative mechanism of artemisinin neuroprotective action against 6-OHDA and MPP+-induced neuronal injury FYN GRB2 SRC PMC4835965__F4 ER stress and autophagy in AD EIF2S1 NLRP3 CLU HEL111 GSK3B MAP1LC3B2 HEL-S-89n CSTB ERN1 IL1B PMC5406529__F1 T cell immune checkpoints for anti‐tumor immunity ZAP70 CD80 CTLA4 PMC8636279__F2 Helminth extracellular vesicles: Interactions with the host immune system IL33 MTOR PMC5965688__F8 Nm23-H1 in cell cycle regulation and apoptosis BAX CDK6 CCND1 CDK4 PMC7253339__F1 NPC and associated factors RCC1 RAN PMC3386226__F8 Rad4TopBP1 ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner TOPBP1 ATR ATRIP CRB2 PMC4030989__F1 Sphingolipid pathway and basic structural units of sphingolipid biosynthesis CERS3 CERS5 CERK SPHK2 CERS1 SGPP1 CERS2 SPHK1 DEGS1 DEGS2 SGPP2 CERS6 PMC9315226__F4 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? BRD4 LRRK2 BRAF PMC4190013__F1 Signal transduction pathway for type I IFNs and a summary of key ISG effects on the virus and mucosal immune response during influenza STAT2 IFNAR2 IRF9 RNASEL IRF7 CXCL10 TYK2 RAC1 PMC5511157__F6 Mediation by Menin of milk protein synthesis through the PI3K/Akt/mTOR signaling pathway in mammary epithelial cells PRLR RPS6 MTOR EIF4E PMC3514012__F5 IPA generates IL-17C interactome CSF2 TRAF3IP2 NFKB2 IRF1 CXCL2 IRAK2 CCL2 IFNG IL17C NFKB1 NFKBIA IL36G LCN2 IL23A PMC3888473__F3 Top genes from SNP comparative analysis CYP2A6 ABCC1 HGF CYP2E1 PCNA SLCO1B1 BNIP3 NR1C2 MYC ABCG1 BCL2L1 NFE2 CYP7A1 MUC1 ABCG2 ABCC2 ABCB1 IL1B BAX NOS2 TNFSF6 PTGS2 MMP9 VEGFA IL6 TNF CYP1A1 CYP2B6 FOXO1 CYP2J2 NFE2L2 BCL2 XDH VCAM1 ABCC5 CYP3A4 ABCC6 CYP4A11 PMC3888473__F4 Pathway analysis on SNPs that affect gene expression and drug response NR1H4 ACHE RPS15A SLCO4C1 CHST3 SP1 SLCO1B1 VTN NR1C2 TNF NR3C1 HNRNPA2B1 GUGU CYP3A4 HNRNPC CYP4F12 SLC24A3 PMC8481945__F2 Melanoma Plasticity: Promoter of Metastasis and Resistance to Therapy PAX3 AXL EGFR SMAD2 NGFR ROR2 BRAF SMAD4 EZH2 MYC CTNNB1 HMGA1 NFIB NOTCH1 PMC4574966__F3 Multi-Marker Genetic Association Test Based on the Rasch Model Applied to Alzheimer’s Disease ATXN3 TP73 RPS6 HEL-S-101 ACO2 APOE MARCKS NUPR1 PLK1 AEN PABPC1 CNTF E2F6 YWHAG PMC5347792__F9 Galectin-1 induces invasion and the epithelial-mesenchymal transition in human gastric cancer cells via non-canonical activation of the hedgehog signaling pathway SHH SMO PMC4348060__F5 Differential network of breast cancer Cell Cycle pathway between early recurrent and non-recurrent patients CDC14B GADD45G BUB1B SFN SMC1A RB1 CDKN1B CREBBP ATM MCM5 MCM6 CDC25B YWHAZ PMC3716752__F1 Toward understanding the genetics of regulatory T cells in ovarian cancer CD80 APC RGS1 CTLA4 FOXP3 TNF PMC9534897__F4 Extracranial arteriovenous malformations demonstrate dysregulated TGFB/BMP signaling and increased circulating TGFB1 SMAD1 HEY2 SMAD6 HES1 PMC6304875__F1 General overview of the autophagic pathway and its regulators ULK1 MTOR ULK2 PMC7600068__F2 Potential mechanism of radiation-induced abscopal effect EGFR ATM PMC4619526__F1 Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study NR1i1 CYP2R1 CYP27B1 CYP24A1 RXRA DHCR7 PMC9315226__F2 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? MAP3K2 MEF2B MAPK7 BRAF NRAS MAP2K5 FOS MEF2C MEF2D PMC6769649__F3 Ligand-dependent EGFR signaling pathways EGF CBL EGFR GRB2 SRC PMC9315226__F3 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? EGFR BRAF IGF1R SRC KRAS FOS PMC7950238__F5 Signaling pathway diagram GSDMD NLRP3 TXNIP GATA4 PMC9315226__F1 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? CDC2 BRAF FOS PMC4309433__F1 Metabolic network of tomato cells FAS TK1 SCO1 HEL-S-162eP MAL CS CIT PMC7642048__F1 Mechanical stretch-induced signaling pathway in VSMCs AIM2 HDAC7 IGF1R SRC SIRT1 PMC8846306__F2 Running ‘LAPS’ Around nLD: Nuclear Lipid Droplet Form and Function LPA HMFN0839 GPAT4 DGAT2 PMC7988785__F1 An update on brown adipose tissue biology: a discussion of recent findings IL17RC TGFBI FGF21 FGF9 FGF7B CXCL14 PMC10380532__F2 mTOR Signaling Pathway and Gut Microbiota in Various Disorders: Mechanisms and Potential Drugs in Pharmacotherapy MLST8 RICTOR TTI1 MTOR DEPTOR PMC3912166__F1 Establishment of HeLa Cell Mutants Deficient in Sphingolipid-Related Genes Using TALENs UGCG ST3GAL5 B4GALT5 A4GALT PMC10380532__F3 mTOR Signaling Pathway and Gut Microbiota in Various Disorders: Mechanisms and Potential Drugs in Pharmacotherapy STAT3 IL33 MTOR PMC540032__F1 CellDesigner () diagram of the insulin/IGF receptor signaling pathway NGF INSR IRS4 PTEN PDK2 MTOR IRS1 PMC3868461__F7 Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter FAS MAL CIT PMC7191095__F3 Main signal pathways of YTHDF2 in human cancers CDH2 MAP2K4 EGFR SOCS2 YTHDF2 METTL3 IL1B PMC2045534__F6 Schematic model of the role played by GADD34 and the mTOR pathway in the suppression of viral replication TSC2 TSC1 MTOR PMC10741975__F5 Compound-pathway network has 41 points and 151 lines CXCR3 PIK3CA PIK3CD JAK3 CCR2 GSK3B CTSK CCR3 MAPK9 MTOR TNF MAP3K14 MAP3K5 CDK4 PMC7267062__F2 Death receptor apoptotic pathway in cancer induced by plant polysaccharides BAX FAS FADD PMC10741975__F7 Chemokine signaling pathway and PI3K-Akt signaling pathway influenced by esaxerenone EGF CDKN1A EGFR CDKN1B PIK3CD JAK3 CCR2 CDK2 CCR3 IL6 SRC IL6R PMC7267062__F1 Mitochondrial apoptotic pathway in cancer induced by plant polysaccharides BAX BAD FAS PMC7555774__F3 Inhibitory signaling events against AngII/AT1R-mediated senescence in VSMC SIRT3 ATG5 SIRT1 PMC8802973__F1 Safety and danger of biologic treatments in psoriasis in context of cutaneous T-cell lymphoma (CTCL) STAT3 JAK3 TNF PMC3384423__F1 MTOR signaling pathway RHEB TSC2 RAN RICTOR TSC1 NF1 PTEN MTOR DEPTOR PMC8669293__F6 Profound changes in cerebrospinal fluid proteome and metabolic profile are associated with congenital hydrocephalus SP1 ZNF148 OTC SULT2A1 CP PMC8669293__F4 Profound changes in cerebrospinal fluid proteome and metabolic profile are associated with congenital hydrocephalus MATK FLT4 NTRK3 CP PMC6600524__F1 Schematic representation of androgen deprivation therapy (ADT) or androgen receptor (AR) antagonist in mediating therapeutic resistance and neuroendocrine (NE) differentiation of prostate cancer (PCa) TGFBI LIF PTGS1 SPDEF CCL2 PMC8194090__F7 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation SOX9 RUNX2 PMC6944213__F6 Genotype, phenotype, and dose effects on Bcl6 inhibition upstream of the secreted factors canonical pathway IFNG IL10 IL12A BCL6 PMC8194090__F5 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation SOX9 SMAD2 RUNX2 PMC8194090__F3 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation SOX9 IHH SMO RUNX2 PMC2949081__F1 Summary of the RAS incorporating the Ang peptide family and physiological effects mediated via ATR subtypes ATR AMBN ACE2 PMC3770247__F1 Hedgehog signaling pathway, a morphogenic signaling pathway important in embryogenesis, tissue differentiation, cell growth and development CSK SHH SMO PMC8194090__F2 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation SOX9 APC GSK3B BMP2 LRP5 LRP6 RUNX2 CTNNB1 PMC7555140__F1 Small heat shock proteins (sHSPs) regulate apoptosis in the extrinsic and intrinsic apoptotic pathways HEL-S-102 CASP3 FADD PMC7249327__F3 From progesterone to Cdk1 activation: the scattered elements of a not fully understood signalling pathway CDC2 FIG4 ARPP19 MOS MYT1 PMC7552005__F1 PKR at the crossroads of virus sensing, innate immune signaling, and stress response pathways TBK1 MAVS TRAF5 IRF3 ATF4 TRAF3 EIF2A TRAF6 TRAF2 PMC5467017__F8 Working model portraying the effects of WNT/Beta-catenin signaling in PTENWT melanoma cells under nutrient starvation conditions APC PTEN CTNNB1 PMC11851658__F1 Pexophagy-related peroxisomal proteins PEX14 EHHADH PEX5 MTOR PEX16 PEX3 PEX13 PMC4017408__F1 Wnt signaling pathway APC GSK3B CTNNB1 PMC6902583__F6 Target network of bradycardia PLN CHRM1 ADRA1D NACA2 CHRM3 NOX4 GDA TRIM21 ADRB3 HCN4 HEL-S-99n KCNA1 CHRM4 REN ADRA1B CACNA1G ADRA2A ADRA2B SP4 UTS2 HCN1 PROC CHRM5 OPRM1 ARHA ANGPT2 RAC1 SEMA3A NPPA CHRM2 AQP9 ADRA2C ADRB2 RGS4 ADRB1 GJA1 CYBB AVP PMC11851658__F2 ROS function as signaling mediators in pexophagy TFEB PEX5 ATM PEX2 PMC5541090__F1 NREP, HIPK2, PRDM16, SMAD3 and their roles in the canonical TGFB signalling pathway TGFBR2 HIPK2 SMAD2 PRDM16 SMAD4 NREP TGFBR1 PMC7462746__F6 cGAS-STING Pathway inhibition by HCQ and CQ: DNA sensor cGAS (cyclic GMP-AMP synthase) can recognize DNA of viral/bacterial origin and synthesize a dinucleotide molecule, cGAMP (2′, 5′-cyclic GMP-AMP dinucleotide) CGAS IRF3 TNF PMC2647628__F1 CATERPILLER (NLR) Family Members as Positive and Negative Regulators of Inflammatory Responses CXCL12 CXCL13 RELA RELB IRAK1 CXCR4 MYD88 PMC7906184__F10 Graphic depiction of the conclusion from the present study SP1 LRRK2 PMC7779278__F3 Pyruvate dehydrogenase kinase (PDK) in immune cell metabolism CD80 CD36 HEL-S-5 PDC HIF1A PMC3348846__F2 Leukocyte recruitment to sites of injury/infection: dominant role of ROS HMGB1 TLR4 VCAM1 PMC4588544__F3 Current models for mitochondrial longevity TAF4 MTOR EIF2A PMC3348846__F3 Role of Rac1/RhoA balance in endothelial barrier integrity: impact of ROS and NO CDC42 ARHA RHO RAC1 PMC8546260__F1 TNFA/TNFR2 Pathway: Targeting a Brake to Release the Anti-tumor Immune Response RIPK3 RIPK2 TRADD C2 RIPK1 TRAF2 FADD PMC9294282__F3 Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair RAD51 KEAP1 RNF4 BRCA2 APC USP11 RIF1 FBXW7 BRCA1 RNF168 RNF8 RFWD3 UHRF1 PALB2 PMC3050844__F5 Aberrant Cell Cycle and Apoptotic Changes Characterise Severe Influenza A Infection – A Meta-Analysis of Genomic Signatures in Circulating Leukocytes CTCF MAL CDK3 PMC5337806__F5 TGFB signaling pathway SMAD1 DKFZp781O1323 SP1 SMAD2 SMAD6 SMAD4 ARHA TNF TGFBR1 BAMBI IFNG RBX1 SMURF1 E2F4 SKP1 SMURF2 PMC7779278__F1 Pivotal role of pyruvate dehydrogenase kinase 4 (PDK4) in regulating the metabolic switch between glucose and fatty acid oxidation in skeletal muscle in physiological and pathological conditions PDK4 CD36 FOXO1 HEL-S-5 PDC IRS1 PMC5337806__F3 MAPK signaling pathway MAX ECSIT CDC42 EGF JUN RAF1 EGFR CD14 TRAF6 FLNA MEF2C NGF MOS NLK GCK BDNF CDC25B PMC8067602__F4 Necroptopic signaling pathway TRADD MLKL TRAF2 FADD PMC5629629__F8 Proposed model of the cell autophagy induced by SAHA and TRAIL DR5-CTSB in breast cancer cell lines MTOR PMC9684732__F4 Endoplasmic reticulum of trypanosomatids: An unrevealed road for chemotherapy TRAF4 TG ELF2 ATF4 XBP1 TRAF2 PMC2938097__F6 TNF/Fas/TRAIL signaling pathway FAF2 FAS RIPK2 TNFSF13 DEDD FAF1 HDAC7 CRADD TNF TRAF2 PMC9544065__F12 Revisiting the therapeutic potential of tocotrienol BAX BCL2 TRAF3 EIF2A PMC4369380__F1 Distinct Integrin-Dependent Signals Define Requirements for Lytic Granule Convergence and Polarization in Natural Killer Cells HEL-S-28 SRC PMC5406714__F1 Targeted Inhibition of Hepatocyte Growth Factor (HGF)/c-Met Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC) STAT3 HGF GRB2 PMC6895828__F4 The cancer signaling pathway and protein network analysis of these up-regulated targets and the prognostic model of the ten-hub gene signature PLB1 CD40 ZAP70 CSF1 SHC1 CARD11 RASGRP3 TNLG7A JAK3 CCR2 CR2 IL21R BBC3 TNFRSF25 EGLN3 BIRC5 XCR1 INHBB OSMR CCR7 FLT1 LPCAT1 KDR IL18RAP JMJD7 RASAL3 P2RX7 RASGRP4 RGS14 CACNA1A CHST11 P2RY1 TNFRSF14 CHST13 RELT TNFRSF9 HK2 IL34 TNFSF6 F2RL3 KSR1 VEGFA ANGPT2 TNFSF14 CXCL11 MAP3K1 ELMO1 IFNAR2 PLA2G6 EDNRA BDNF CYBB IL12RB1 IL10RB IL20RB CXCL9 DUSP10 TNFRSF1B PLCB4 FAS TGFA TGFB1 TRADD TNFAIP3 EGFR TNLG8A SHC2 NCF1 ABCG1 CSF2RB INSR CX3CL1 NOTCH3 BIRC3 CACNB1 BAX PDGFD LCP2 DLL4 NGFR CD40LG IGF2 IL2RB CCL28 IL24 CCR4 CFTR IL7 LCK HRH2 PMC4040907__F6 The impact of 5q deletion upon myeloid cell fate GATA2 CEBPA EGR1 HNRNPA0 NAB2 IRF8 EGR2 PMC4774567__F1 Target function of MALAT-1 in cancer SOX17 BAX CDK6 SP1 SFPQ CCND1 pp6425 PMC7569310__SF1 Transient Receptor Potential Ankyrin-1 and Vanilloid-3 Differentially Regulate Endoplasmic Reticulum Stress and Cytotoxicity in Human Lung Epithelial Cells After Pneumotoxic Wood Smoke Particle Exposure ATF3 DDIT3 ATF4 EIF2A XBP1 PMC7565963__F1 Hedgehog signaling pathway KIF7 BOC SUFU PTCH1 SMO PMC11967251__F7 Mechanism graphic in this study STAT3 VEGFC IGF2BP3 SRC PMC3990910__F3 Mechanisms of Notch signaling silencing in AML MAML1 MAML3 LFNG NOTCH2 HES5 PMC3990910__F1 Mammal Notch receptors, ligands, and canonical activation pathway EGF NRARP ADAM10 NOTCH2 NOTCH3 NOTCH1 PMC6539122__F7 Interaction network of proteins involved in cancer, immune system, and signal transduction pathways PRKD3 ZAP70 STAT3 RAF1 SDC4 TAP1 MYC MAPK8 MAPK14 CDK6 NCOR1 CCR7 APAF1 CSF1R CASP8 SIN3A MYH10 KSR1 NCF4 HEL70 PIP4K2A CDC34 MTMR1 PSMD13 ARPC1B DAPP1 SCIN CHD4 DDB1 RASA3 BMP2K POLR2B PSMC6 MAP3K5 GNA13 VDAC3 ARPC4 ARPC2 AGPAT4 RPS6KA1 PRKCB GNB1 TPR PLCG1 RASA2 CTBP1 IL18 MAP2K3 YWHAG DTX3L HDAC1 HEL-S-162eP ACVR1 ADA SYK PSMD12 VAV2 PTPRC IRAK4 DOCK2 MAP3K2 ETV6 STAT5B PDPK1 HSPA2 HEL-S-1 INPP5D HEL-S-28 PGAM1 RUVBL1 GNA11 CXCR4 CYBB CDC42 UBE3A CTNND1 ATP2A2 PSMD2 PSMD1 BTK SNRPD1 MYH9 CHUK CDC2 CD81 DDX5 JUN PTPN6 SSB PDE3B CAMK2D SKP1 DVL3 RPS6KA3 RPS6KA5 TRAF2 CAMK2G PMC7514027__F6 Vanadium-protein complex inhibits human adipocyte differentiation through the activation of Beta-catenin and LKB1/AMPK signaling pathway FAS EPO CTNNB1 PMC3393821__F2 Altered expression of cytokine signaling pathway genes in peripheral blood cells of alcohol dependent subjects: Preliminary findings IL15 STAT3 TNFRSF1A NFKB2 RELB JAK3 IL21R TNF IL-21 IFNAR2 IFNAR1 NFKBIE BCL2 RIPK1 JAK1 TRAF2 PMC3384423__F4 CRLs/SCF E3 ubiquitin ligases regulate mTOR pathway TSC2 RBX1 CUL4A TSC1 PHLPP1 CUL7 MTOR VHL PMC4456188__F1 Mechanisms by which Beta-cell failure an apoptosis occur are complex, not completely unraveled and involve the interplay of numerous factors and conditions ATF3 TSC2 PDX1 TSC1 GSK3B MAF MTOR IRS1 PMC12004233__F5 Significant differentially expressed unigenes enriched KEGG pathway analysis by the comparative transcriptomic analysis of Mro-IR knockdown EHD2 EGF OCA2 EGFR SMAD2 MTOR INS TGFBR1 TGFBR2 CBL GNRHR INSR LDLR MDM2 GRB2 CCND1 PMC4389579__F1 Conceptual model of general lifestyle factors, salient CHD pathogenetic pathways and CHD hallmarks TF TH NLRP3 COX1 IGF1 VCAM1 MIF MPO PMC4509079__F1 BMI-1 is important in the regulation of cancer and CSCs, functioning through the activation of multiple signaling pathways BMI1 SALL4 MYC PMC8038495__F9 Proposed scenario of the altered mechanisms driven by HFD/IPA treatment OGA OGT IRS1 PMC5799234__F1 C-type lectin receptor (CLR) signaling in fungal recognition RASGRF1 SYK RAF1 NLRP3 BCL10 TLR4 IRF3 IL1B CARD9 MYD88 PMC9105460__F1 Immunotherapy for HER2-Positive Breast Cancer: Clinical Evidence and Future Perspectives HLA-E APC CTLA4 RET PMC3448082__F1 A simplified model of the feeding regulation hypothesis involving the hypothalamic neuropeptide signaling pathway CCK PYY POMC PMC5413580__F1 Generalized schematic of checkpoint molecule structure and expression, and the balance between stimulatory and inhibitory signaling HEL-S-92n CD80 HMGB1 CEACAM1 CD200R1 APC SIRPA CD200 CD47 LAG3 PMC4445746__F3 Predicted interactions between miRNA and mRNA targets within addiction relevant signaling pathways PRKCE PMC8175775__F6 Identification of Tumor Necrosis Factor-Alpha (TNFA) Inhibitor in Rheumatoid Arthritis Using Network Pharmacology and Molecular Docking TRADD TNF FADD PMC2705893__F1 Protein kinase Cι: human oncogene, prognostic marker and therapeutic target EGF BAD HGF PAK1 EGFR SRC MYC RAC1 PMC6030972__F6 Interactive KEGG diagram for Signaling pathways regulating pluripotency of stem cells HRAS TH TG MAFK TCF3 BAD INHBA GSK3B ELL GRB2 PMC4558313__F4 Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes CRTC2 PC MCU HEL-S-11 PMC5992426__F2 Venues of prenatal alcohol exposure (PAE) altering neuroinflammation GFAP TLR4 CCR2 VCAM1 BDNF CCL2 IL1B PMC9412785__F1 RAS signalling pathway and therapeutic approaches to target this pathway in cancer RHEB AURKA TSC2 TSC1 SOS1 SOS2 WEE1 HEL-S-28 PTEN GRB2 CDK4 PMC5108086__F3 Toll-like receptor signaling pathway color-tagged by co-morbidity findings CDC42 CD40 GAL TIRAP CTSK CD14 IL4 ARHA TRAF3 SHE CRK TLR1 TIAM1 TLR4 PDC TLR8 ITK TLR7 GRB2 LBP CP FADD PMC8864228__F2 Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases AQP4 ROS1 GDNF HEL-S-62p AQP9 IL1B PMC8003205__F2 CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 screens identified genes involved in Gb3 biosynthesis, with a schematic diagram of the Gb3 biosynthesis pathway and a summary of the top genes identified in CRISPR/Cas9 screens UGCG SLC35A2 TM9SF2 LAPTM4A AHR B4GALT5 TMEM165 KDSR A4GALT PMC7370165__F7 M2 polarization of tumor‐associated macrophages is dependent on integrin B3 via peroxisome proliferator‐activated receptor‐G up‐regulation in breast cancer CD36 FASN PMC6061668__F1 Endothelial injury pathways in thrombotic microangiopathies TF VWF CFI CFH VCAM1 MPO PMC3322527__F7 TGFB signaling pathway overlaid with differentially expressed genes GSC NODAL SKI PMC7479667__F3 Indirect and metabolic effects of stress on T cells CD80 MTOR PMC5038883__F6 Proposed mechanism by which V8 induces apoptotic cell death in human multiple myeloma RPMI 8226 cells BAX ATF4 EIF2A PMC4738049__F2 Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection IFNAR2 JAK3 IL21R RAG2 TYK2 PMC4549294__F14 UVB-Stimulated Expression of Transglutaminase 1 Is Mediated Predominantly via the NFKB Signaling Pathway: New Evidence of Its Significant Attenuation through the Specific Interruption of the p38/MSK1/NFKBp65 Ser276 Axis EGFR GSK3B TRAF6 PMC6335097__F9 Simplified signaling pathway for vasopressin-mediated sodium-chloride cotransporter (NCC) regulation in distal convoluted tubule (DCT) cells SGK1 OSR1 PMC6519110__F1 Intracellular NAD+ metabolism in eukaryotic cells NNMT PNP NAPRT NMNAT1 NAMPT NMNAT2 NADK2 NADSYN1 NMNAT3 PMC3423373__F3 Transcriptional Programs Controlling Perinatal Lung Maturation HEL164 PPARG GATA2 JUND NRP1 PIK3R1 SOCS3 EFNA1 RB1 TRIM28 BCR E2F3 KDR SOX17 BMPR2 SMARCC1 TIMP3 CBX2 BATF APOE HEL-S-28 TGFBR3 EZH2 VEGFA FGF10 MDC1 FOS SET ENG HBEGF L3MBTL2 APEX1 EDN1 CDK2 ADRB1 IL8RB HMGB2 PTPRM F11R TMOD1 KLF2 HELLS FAS CREB3 HCLS1 CDC20 RRN3 PCNA PMF1 HEL-S-62p EGFR ORC6 BRCA2 MYEF2 PDE4DIP GUCA2A CENPE TUBA1B BLM TEAD4 CSF3R CSF2RB PRKCE NME2 F2R F3 CHEK2 AHR ATM ACVRL1 DBF4 HMGB1 THBS1 B4GALT1 CITED2 ECT2 CBX3 ORC2 NFYB GMNN DEK CHEK1 BMP2 CCR4 PTPRE EHMT1 MAP3K6 PMC4657041__F9 The role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia RB1 SMAD4 EP300 DROSHA PMC7721010__F8 Schematic regulation mechanism of miR-361-3p on lymphoma cell behaviors WNT10A CCND1 CTNNB1 PMC6029413__F2 Multiple roles of the extracellular matrix (ECM) in modulating the cancer-immunity cycle HEL-S-92n CCR7 VCAN PMC7738607__F2 Skin immune response in dermatophytosis STAT3 SYK EGF EGFR CXCL1 TNF CXCL8 IFNG IL17RA NLRP3 IL23R CARD9 IL1B PMC4075065__F1 Insulin/mTOR signaling pathway and also the extrinsic modifiers that are present in diabetes AKT3 IRS4 MTOR IRS1 PMC6027159__F11 cGAS/STING signaling pathway CGAS TRIM32 TRIM56 PMC6027159__F12 TCR signaling pathway SHARPIN MAP3K7IP1 BCL10 USP2 TAB3 TRAF6 PMC6027159__F10 RIG-I/MAVS signaling pathway TRIM31 SHARPIN MAP3K7IP1 MAVS TRIM25 TAB3 TRAF5 TRAF6 TRAF2 PMC3376961__F1 Annexin A2 pathway in pancreatic cancer invasion and metastasis ANXA2 RHO PMC2908610__F1 Death receptor pathway via Fas ligand and Fas receptor FAS FADD PMC5571522__F7 Diagram of CPT inhibiting IGF‐1/AKT/mTOR pathway via suppressing the ERA in breast cancer IGF1 PTEN IGF1R IRS1 PMC6027159__F13 Genotoxic stress signaling pathway SHARPIN MAP3K7IP1 TAB3 ATM RIPK1 TRAF6 PMC9482139__F2 Energy metabolism pathways in breast cancer progression: The reprogramming, crosstalk, and potential therapeutic targets HEL-S-133P HK2 PMC12110588__F3 Structure, conserved motifs, and anti-interferon activities of programmed death-1 ligand 1 STAT3 JAK1 PMC6995521__F7 Differentially expressed proteins in the Cyp27a1−/−Cyp46a1−/−Soat1−/− vs GAA LAMTOR3 HEL-S-5 BPHL PMC2715971__F2 Interaction between insulin and interferon-alfa signaling pathway STAT1 STAT2 IFNAR2 IFNAR1 JAK1 TYK2 PMC9482139__F1 Energy metabolism pathways in breast cancer progression: The reprogramming, crosstalk, and potential therapeutic targets FH GLS HEL-S-133P PHGDH FASN PSPH PMC6626719__F3 Aberrant activation of the Wnt/Beta-catenin signaling pathway in hepatocellular carcinoma CAD APC GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC6838672__F3 High-Throughput Assessment of Kinome-wide Activation States CDC42 MAF BRAF NLK CDK9 CHKA PMC7226390__F7 Schematic abstract of the oncogenic and CSCs-promoting role of MALAT1 in HCC STAT3 TWIST1 CTNNB1 PMC6520011__F1 Impaired ribosome biogenesis RPL5 RPL11 POLI MDM2 PMC8022952__F1 Expected flavonoid biosynthesis pathway in maize C2 PMC3757426__F1 Epidermal growth factor receptor (EGFR) crosstalk ERBB3 ERBB4 EGFR ERBB2 IGF1R SRC PMC9506007__F2 Regulation Mechanism of Plant Pigments Biosynthesis: Anthocyanins, Carotenoids, and Betalains RFWD2 MYB PC PMC4792076__F7 Schematic view of B3 integrin–GSK3B and BMP-2–Smad cooperation SMAD1 BMP2 HEL-S-28 SRC PMC10993494__F9 Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development PPARG PIK3R1 PMAIP1 CXCL8 MYD88 IFNG MMP3 LPL NOS2 ADM SP1 PMP22 INPP5D TNF FURIN ACACB ANGPTL4 CEBPA PNPLA3 IGF1 FOXO1 EDN1 RXRA Nbla10317 CYP46A1 CCL4 ELOVL6 CDC42 TGFB1 LEP CD36 PGR ARPC3 PPP1R10 ATP5IF1 FADS1 MPO USP48 INSIG1 STRADA CCKBR ZNF117 TMEM169 NR5A2 CEBPB IL1B FASN PNPLA2 PTGS2 IL6 RAC1 FGF7 FADD PMC7910618__F4 Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/Beta-catenin/PPARD signalling NR1C2 CXCR4 CTNNB1 PMC3368988__F2 Sites of PP2A activity within the network of ERK activation RAF1 KSR1 SRC PMC138773__F1 EGFR transactivation by GPCRs and cytokine receptors EGFR SRC PMC5439543__F1 CHEK2 pathway FOXM1 NEK6 BRCA1 BRCA2 ATM CDC25B PMC5644640__F1 Summary of potential beta adrenergic signaling pathways in canine hemangiosarcoma and human angiosarcoma PTGS2 MMP9 SRC PMC4407294__F1 PI3K/AKT/mTOR and the RAS/RAF/MEK/MAPK pathways RHEB TSC2 TSC1 GSK3A FOXO1 GSK3B PTEN PMC4407294__F2 Molecular pathways regulating breast cancer stem cells (CSCs) STAT3 CXCR1 EGFR RELA SMO PTEN IL8RB SRC CTNNB1 PMC4754414__F1 Pathways for molecular targeting in prostate cancer radiotherapy RAD51D ATR RAD51 CYP17A1 MRE11A BRCA2 ATM PTEN HIF1A MTOR MDC1 XRCC3 PMC2729812__F1 Proposed pathway from pressure overload to LV hypertrophy and fibrosis HBEGF TGFA ADAM12 PMC10506215__F3 PTM of PGK1, including acetylation, phosphorylation, ubiquitination and O-GlcNAcylation HDAC3 HEL-S-68p MTOR PMC2908510__F3 Normal and Cancer-Related Functions of the p160 Steroid Receptor Coactivator (SRC) Family IGF1 EGFR ERBB2 GAB2 IRS1 PMC8010917__F2 NLRP3 activation pathway NLRP3 IL1B MYD88 PMC4029299__F3 Gene- and pathway-based connectivity map of vismodegib and Gorlin syndrome PTCH2 SUFU SMO PMC4455035__F2 Pericytes, microvasular dysfunction and chronic rejection ANGPTL4 ARHA BDNF PMC8036964__F7 Target-enriched KEGG pathway network for UR alkaloids against AD CCR5 GSK3B NTRK3 CHRM3 PSEN1 MAOA PSENEN DRD1 MME FYN DRD2 ALOX5 DRD4 APH1B CHRNB2 FGFR1 MMP2 MMP3 PDE4D CSF1R P2RX7 NOS2 NTRK2 CDK5 CHRM2 PSEN2 ADRB2 MAPK10 IL8RB GRIN2B HTR7 HTR4 HTR2A MTOR DRD3 HTR6 SLC6A3 ADAM17 SLC18A2 INSR GABRA5 5HT1A CCND1 CDC2 ACHE KIT MMP9 PTGS2 PARP1 CASP3 NTRK1 ERBB2 FGFR3 PMC11848799__F2 Monocyte eukaryotic initiation factor 2 signaling differentiates 17-hydroxy-docosahexaenoic acid levels and pain REST MAL ELF2 EIF2A EFS PABPC1 PMC11933059__F2 PAM pathway mechanism of action CDK6 PTEN CDK4 PMC8953665__F4 Cholesterol metabolism: from lipidomics to immunology APOC2 APOC1 SOAT2 APOE DHCR24 MYLIP ABCA1 HMGCS1 ABCG1 ABCG8 ABCG5 HMGCR APOC4 LDLR SOAT1 DHCR7 FDFT1 PMC1413813__F8 The signaling pathway regulating the expressions of SMAlpha-actin, SM-MHC, and calponin in SMCs on polymerized collagen in response to PDGF-BB/IL-1B costimulation IL1R1 HEL-S-66 MTOR PMC8953665__F1 Cholesterol metabolism: from lipidomics to immunology LIPA STAT1 TLR3 TLR4 CH25H SOAT1 CYP27A1 IL1B PMC6705791__F5 Proteome-transcriptome alignment of molecular portraits achieved by self-contained gene set analysis: Consensus colon cancer subtypes case study PCK2 APOC3 EHHADH ACSL3 ADM SCD DBI RXRB PMC6705791__F6 Proteome-transcriptome alignment of molecular portraits achieved by self-contained gene set analysis: Consensus colon cancer subtypes case study TAPBP HLA-DOB HEL-S-269 B2M HLA-DRA HLA-E CD74 HLA-G A2M HLA-DRB4 TAP2 HLA-B HLA-C HEL-S-283 PSME2 PMC4293272__F2 Cell Signaling Pathways Involved in Hematopoietic Stem Cell Specification SMAD1 DKFZp781O1323 WNT16 BMP4 VEGFA NOTCH1 CTNNB1 PMC4729769__F7 Schematic Diagram Depicting the Proposed Role of P-gp in the Formation of Peritoneal Adhesions following an Abdominal Operation TGFB1 SMAD2 PMC5095004__F9 MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma FAS ULK1 MAL MTOR PMC9354322__F3 Pleiotropic roles of cGAS–STING signaling in the tumor microenvironment IFNE POLI IRF3 PMC8304710__F2 Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer MTHFD2 PINK1 HEL-S-133P HK2 HEL-S-30 HEL-S-51e HEL-S-68p PHGDH HEL-S-162eP MTHFD1L ENO1 PFKL COXFA4L2 PSPH MXI1 PMC4563985__F3 Proposed mechanisms of activation of proinflammatory signaling pathways in IFN-mediated autoinflammatory diseases TBK1 CGAS MAVS STAT2 IRF3 IRF7 JAK1 TYK2 PMC4177461__F2 Helicobacter pylori mediated downregulation of B7-H2 on gastric epithelial cell inhibits Th17 cell development and facilitates bacterial persistence ICOS MTOR PMC5983750__F1 Molecular pathways involved in senescence IL10 ATM IL1A MTOR PMC3479314__F1 SHEDDING NEW LIGHT ON NEURODEGENERATIVE DISEASES THROUGH THE MAMMALIAN TARGET OF RAPAMYCIN RHEB MLST8 TSC2 TSC1 MTOR DEPTOR PMC9530903__F6 Metabolome and transcriptome association analysis revealed key factors involved in melatonin mediated cadmium-stress tolerance in cotton AGXT2 IVD DBT DLD PMC3811932__F1 Growth factors, insulin, nutrients and energy status regulate the activation of the PI3K/Akt/mTOR signaling network RHEB MLST8 TSC2 BAD RICTOR MAP4K3 TSC1 PTEN MTOR IRS1 PMC9442330__F2 Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders LPA DHRS7B PXMP2 AGPS GNPAT PC PMC6473256__F8 Cilia-dependent and independent activation of Gli proteins SUFU PTCH1 SHH OLIG2 SMO FOXA2 PMC12052750__F4 Gut microbiome imbalance disrupts the gut-lung axis IFNG NLRP3 IL1B PMC8117532__F6 Role of chimeric genes in pathway-related gene co-expression modules TH APC PMC3756172__F1 Summary of AERD associated single nucleotide polymorphisms in the genes of immune response and arachidonate pathway NAT2 PPARG PTGER2 PTGER3 CACNG6 SMOC2 SP1 LTC4S ST7 FCER1A IL13 KPG_011 CD14 SLC22A2 IL4 ADAM33 IL5 SLC6A12 NLRP3 TLR3 TLR4 RS1 PTGER4 PTGIR PMC3196377__F6 Regulator of G Protein Signaling 6 (RGS6) Mediates Doxorubicin-induced ATM and p53 Activation by a Reactive Oxygen Species (ROS)-dependent Mechanism RGS6 ATM MDM2 PMC4032668__F3 Simplified scheme of the DAF-16 signalling pathway in C SGK1 PMC4846574__F12 P21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events CDC42 SRC RAC1 PMC8151260__F1 Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies OSM PIM1 JAK3 BCL2 JAK1 CISH MYC PMC4192477__F2 Numerous proteins that interact with core components of the NOD2 and MAPK signaling pathways were identified as regulators of IL-8 secretion DUSP10 MYO1D AVPR2 MAVS ITCH PML TERT ATF2 PIN1 NCF1 MAPK3 CARD8 MAPK14 MYLK ELF4 BTRC RIPK2 SNAI1 NOD2 UBE2D3 ATM UBE2L3 SIN3A CAD JDP2 PLD2 RNF31 USP31 SIRT5 COMMD8 COMMD9 PPP2R1A hEMMPRIN CARD6 IRAK1BP1 CCDC6 HDAC1 BRCA1 RELA PPP2R1B RUVBL2 CDK5RAP3 CASP10 YWHAZ ELF3 PMC3081368__F8 HMGB factors are required for posterior digit development through integrating signaling pathway activities HMGB1 SHH HMGB2 CTNNB1 PMC6156463__F2 Metabolism of SAM MTAP MTOR PMC2731678__F3 PAK Signaling in Oncogenesis BAD RAF1 HEL-S-28 PCBP1 CCND1 PMC6156463__F5 Distinct metabolic pathways in cancer cells and their connection to epigenetic modifications ACLY GLS MTAP HEL-S-133P F5 HK2 NAMPT MTOR PCK1 ACSS2 PDC HEL-S-32 MDH2 HEL-S-26 PMC3911500__F7 Schematic model for how S6K1 inhibits TLR2- or TLR4-mediated signaling pathways MAP3K7IP1 TLR4 TRAF6 PMC6999456__F2 Sketches for DCA synthetic pathways C6 FAS C9 PMC1664664__F2 Neurotrophin signalling JUN FRS2 RHO GRB2 PMC5010673__F2 Summary of interactions involved in Wnt signaling cascades inferred to regulate NC biological functions DVL1 VEGFC GSK3B MYC CTNNB1 TLE2 BCL9 CTBP2 BTRC CCND2 CTBP1 SENP2 CCND1 NKD1 CCND3 FRZB JUN MAP4 APC DVL2 PYGO1 RHOU MAP3K1 CTNNBIP1 AXIN1 EP300 WIF1 DAAM1 PMC4563985__F4 Mechanisms of NFKB-mediated diseases CARD14 RIPK2 MAVS BCL10 TAB3 NOD2 IRF3 PMC6314674__F1 Metabolic pathways controlling macrophage activation states IFNG MRC1 FAS IL16 MRC2 ARG1 PMC4644679__F1 Hippo signaling pathway and main regulators BIRC5 ID2 HEL-S-62p SOX2 RHO NF2 AREG MYC VGLL4 AXIN2 CTNNB1 PMC4574066__F2 Downstream analysis of Wnt-related gene expression from aged animals predicts a decrease in cell viability and transcription of RNA IL10 ETS2 EGFR LIF IL4 IRAK1 IL1A MYC CCL2 CORT SERP2 SOX9 FOSL1 TLR4 RELA BMP4 IL18 SHH CCND1 PMC4911124__F8 Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection ISG20 HNRNPAB SFTPB POSTN HEL-S-277 C1QA AKAP12 SGTA PMC5745765__F12 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature IFNG TSLP TGFB1 HGF CD1A IL33 PMC6279911__F1 MiRNA targets in teleost fish immune system STAT1 MAVS STAT2 IRF9 IRF3 IRF7 TYK2 MYD88 PMC5745765__F10 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature IFNG TSLP TGFB1 HGF CD1A IL33 PMC5745765__F11 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature IFNG TSLP TGFB1 HGF CD1A IL33 PMC3137710__F2 Chemical ‘Jekyll and Hyde’s: Small-molecule inhibitors of developmental signaling pathways TNKS2 APC GSK3B AXIN1 AXIN2 CTNNB1 PMC4931673__F3 Circuitry of amino acid signalling to MTORC1 RHEB MLST8 TSC2 RAB1A TSC1 ARF1 SH3BP4 FNIP2 TBC1D7 FLCN MTOR PMC8392360__F1 PI3K/Akt Pathway: The Indestructible Role of a Vintage Target as a Support to the Most Recent Immunotherapeutic Approaches IFNG PTEN MTOR PMC8392360__F2 PI3K/Akt Pathway: The Indestructible Role of a Vintage Target as a Support to the Most Recent Immunotherapeutic Approaches BTK BRAF CTLA4 PMC5814187__F8 Dock derived compound against laminin receptor (37 LR) exhibits anti-cancer properties in a prostate cancer cell line model KPNA2 FTH1 UBE2C MCM3 WDHD1 UBE2S MCM6 ASNS PMC4189494__F6 Schematic representation of the negative regulation of TLR3 and TLR5 signaling by MUC1 TLR3 MUC1 TLR5 IRF3 MYD88 PMC6850916__F7 Inhibition of leucocyte migration was included in early moderate exercise‐mediated improvement of inflammation CXADR NR1i1 THBS1 TNLG1B TIRAP LILRB3 MYC FGF2 MYLK ALOX5 HEL-S-69p SFTPC P2RY4 P2RX1 HLA-A MMP28 ACR HRH2 PMC3109866__F1 Converging Pathways in Lifespan Regulation RHEB TSC2 RICTOR TSC1 SGK1 PTEN PMC2881822__F8 ERB Impedes Prostate Cancer EMT by Destabilizing HIF-1A and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading NRP1 VEGFA PMC6167544__F8 Cellar signal transduction pathway induced by GALT IRAK1 APP IRAK2 TRAF6 IRAK4 IL1B MYD88 PMC5061784__F3 HER2/PI3K/PTEN/Akt/mTORC pathway and potential sites for intervention with small molecule membrane‐permeable inhibitors and monoclonal antibodies (MoAbs) RHEB RPS6 MLST8 TSC2 RICTOR TSC1 ULK1 PTEN GRB2 MTOR DEPTOR IRS1 PMC6110865__F6 KLHDC7B and the Interferon signaling pathway BAX STAT2 IRF9 IFIT1 IFIT3 IRF1 TAP1 IRF7 IFI35 IFNG STAT1 RARB PIAS1 PMC5839951__F1 IGF-1 signaling mediated cell-specific skeletal mechano-transduction SOST IGF1 MSC IGF1R MTOR AXIN2 PMC6943569__F4 Activation of NF-кB by the canonical and/or the noncanonical pathway RELA RELB REL PMC6567082__F1 Crocus sativus extract affects the cell cycle by blocking the G2 and S phase via p53 and CyclinB-cdk2 proteins BAX BCL2 CDC25B PMC5645510__F2 KEGG pathway “FOXO signaling pathway” is regulated by let-7 miRNA EGF KLF2 IL10 SMAD4 BNIP3 PTEN IL6 INS SKP2 INSR CDK2 ATM HEL-S-11 NLK MDM2 PMC12087082__F4 Purine metabolic pathway CYP1A2 APRT NMT1 ADK ADSL NMT2 PMC3235480__F2 RAF/MEK/ERK and the PI3K/AKT/mTOR signaling pathways are shown BAD PTEN MTOR PMC7564661__F4 Membrane damage signaling TRIM16 NLRP3 TXNIP IL1B PMC5383353__F1 IRS4 signaling in malignant cells and therapy resistance NRG2 NRG1 IRS4 IRS1 PMC4652402__F2 Linear Motifs in T cell receptor signalling pathway hsa04660 CDC42 ZAP70 IL10 LAT IL4 RHO IFNG ICOS CBL FYN BCL10 IL2 ITK GRB2 LCK PMC4516574__F11 Hypothetical model illustrating p53 transgene mediated inhibition of Type I IFN signaling during VSV infection STAT1 STAT2 IRF3 TYK2 PMC9657855__F9 Storax Attenuates Cardiac Fibrosis following Acute Myocardial Infarction in Rats via Suppression of AT1R–Ankrd1–P53 Signaling Pathway BAX ANKRD1 MDM2 PMC6121259__F5 Signaling pathways involved in TNF/Thy-1-induced astrocyte polarization and migration THY1 SRC TNF PMC9354322__F1 Pleiotropic roles of cGAS–STING signaling in the tumor microenvironment STAT3 CGAS IRF9 IRF3 JAK1 TYK2 PMC12216578__F4 Effect of PM2 CAD LAT FGFR1 RHO PMC11796190__F7 Diagram highlights the distinct mechanisms by which EA and MA modulate hypothalamic function in PCOS ITGB1 SMAD2 TGFBR1 PMC8431827__F2 Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan Beta-Coronaviruses HMOX1 NFE2L2 CCL2 CXCL8 PMC4317626__F1 Complement activation pathways CD59 C2 CD46 PMC10242860__F4 Ferritin in cancer therapy: A pleiotropic tumoraffin nanocage‐based transport TBK1 TLR9 IRF3 PMC7664177__F2 Canonical Pathway of NFKB which represents the pro-inflammatory response, and Keap-Nrf2-ARE Pathway which represents anti-inflammatory response CSA2 KEAP1 COX2 MAF TNF PMC4149376__F8 Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways BSN NGF SFRP4 DBH WNT7A ChAT MAP2 BDNF CTNNB1 PMC4892113__F4 Role of Spermidine-TCPTP in the complex dynamics of pro- and anti-autophagic factors TSC2 ULK1 EGFR ATM EP300 PMC9138936__F4 Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer’s Disease UVRAG HDAC6 PMC8276693__F2 Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy IFNG STAT1 APC IRF1 JAK1 PMC4480265__F2 Sensing of cell death by myeloid C-type lectin receptors CXCL1 CXCL2 TNF CARD9 PMC8253910__F5 Normothermic Ex-vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis UFD1L MISP3 MGST3 PPARG SRSF7 BOD1L1 ROGDI SLC3A1 ETFB HPCAL1 SRP14 CHCHD4 ABHD10 EPB41L3 TRAPPC13 NR1C2 WASHC1 RXRG SLC22A10 DECR1 FN3K LIPA AMN PABPC4 RPS3A RMDN2 MME CDHR2 USP40 ATP6V1B1 HABP2 PPARGC1A CPT2 RXRB ACO2 GBA2 RPL21 MPC2 CYP4F8 CYP1A1 HOGA1 NR1C1 PLXDC2 RUVBL1 RXRA PMC9038420__F2 Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress RBX1 KEAP1 PMC6277552__F1 Iron metabolism in prostate cancer microenvironment LIPI IL6 PMC2674123__F10 Signaling cascade of PI3K/AKT pathway RHEB BAD HEL-S-28 PTEN CDC37 GRB2 MTOR GAB2 EIF4E PMC11023972__F3 DDR components regulate cytosolic RNA sensors-dependent IFNs and NFKB signaling pathways TBK1 MAVS ATM IRF3 IRF7 TRAF3 PMC11023972__F4 DDR components regulate NFKB signaling pathways TLR9 TLR8 ATM IRF7 TLR7 TRAF6 MYD88 PMC11023972__F1 DNA-damage response pathways XPA ATR ATRIP RAD51 H2AX WRN BLM XPC DDB2 DDB1 RECQL RAD17 ATM POLE MGMT PMC11023972__F2 DDR components regulate IFNs signaling pathways BRD4 TBK1 ATR CGAS RAD51 BRCA2 IRF3 IFI16 BLM FANCD2 BRCA1 ATM TREX1 PMC4926799__F3 Summary of the mechanisms by which stress-related immune alterations may precipitate depression RORC UNK IL1B PMC11023972__F5 DDR components regulate JAK-STAT signaling pathways STAT1 FEN1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 BLM TYK2 PMC10500222__F1 CELF2 affects ferroptosis through the MAPK signalling pathway TFRC GLS GPX4 ARF6 FACL4 WDR76 NFATC1 SLC7A11 ALOXE3 CELF2 PMC4573837__F1 Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal cell carcinoma and other solid tumors EIF4B RICTOR MTOR EIF4E PMC10500222__F2 CELF2 affects ferroptosis through the PI3K/AKT signalling pathway FTH1 FYN EIF4EBP1 GPX4 NQO1 MT1G PTEN SLC7A11 MTOR CELF2 PMC7892952__F1 Adenine-based purines are ubiquitous compounds present at intra- and intracellular levels in normal (i.e., astrocytes) and tumoral (i.e., GSCs) cells NTS PMC4748411__F4 Differential Expression of Genes and DNA Methylation associated with Prenatal Protein Undernutrition by Albumen Removal in an avian model HLA-DOA FOXP2 CPM ARRDC3 MT4 NR3C1 MAGEA4 PMC7398916__F5 BCR Signaling Pathway with FCRL genes SYK CD79B CD79A RAF1 SOS1 SHC1 VAV2 NFATC2 CARD11 RASGRP3 GSK3B PIK3R1 CD22 ATF2 PPP3CA MYC MAPK8 PPP3CC TEC FYN PLCG2 PDPK1 E2F3 STM7 FCRL5 LAT2 CREB1 FCRL3 PIP5K1A PTPN18 NCK1 CRKL INPP5D VAV1 HRAS DAPP1 CRK FOXO1 RAPGEF1 CALM1 GRB2 IMPACT MAX CDC42 HCLS1 PIP5K1C RPS6KA1 BRAF IKBKG MEF2C BTK PLCG1 CHUK CD81 JUN BLNK CD19 IRF4 PTPN6 RAC1 MEF2D BLK CBL GSK3A NFKB1 IKBKB RELA NFKBIA LYN REL GAB2 BCL6 LCK PMC3968564__F1 1A: Base excision repair (BER) pathway targets DNA damaged during replication or by environmental agents RAD51B ERCC1 XPA RAD52 RAD51D RAD51C XRCC3 XPC PMC6466823__F4 Main pathways and respective genes found in different treatments of ECs CDC42 PTX3 CD59 RAB10 CANX CTNND1 GNG12 PROCR GRN CSTB CTNNB1 GNB1 HLA-DRA CD9 PRKCA HLA-DQA2 MCAM HEL-S-43 MYOF RAB14 GNB2 METAP2 PTPN1 ARHA FGF2 CKAP4 NPC2 CD44 LAMP2 ENG RAB11A PRKDC STOM RELA HLA-B HLA-A PMC6376179__F4 Mutations in key pathways controlling cell growth STAT3 RAF1 EGFR AKT3 JAK3 BRAF PTEN IGF1R RB1 CDKN2A CCND2 NF1 FGFR1 ATM TBX3 CCND1 RUNX1T1 KRAS RAC1 GATA3 ERBB3 TSC2 TSC1 RUNX1 MAP3K1 CDKN1B IKBKB FGFR3 MAP2K2 PMC4677035__F6 FcGR-mediated phagocytosis pathway in the KEGG database is the putative pathway which is related to TNFA and TGFB1 expression in microglial cells SYK VASP LAT MARCKS GAB2 PMC10500222__F5 CELF2 affects ferroptosis via the Wnt/Beta-catenin pathway COX2 PAK1 GPX4 LRP6 CELF2 CTNNB1 PMC10420029__F8 Transcription related pathways in the seminal tissues of P RAN RBM22 NUP214 NMD3 PHAX CCNH OTP ELF4 CDK7 EIF5B TBP NUP85 THOC7 EIF4B PAIP1 NUP107 NUP205 ELF2 TAF4 POM121 NUP188 TAF9 PUF60 NUP62 TAF15 MAGOH RANBP2 AQR TAF12 CCDC12 TAF13 TAF11 THOC6 NUP153 CHERP ELF1 SUI1 NUP93 TAF7 TAF6 SNRNP27 NUP54 SLU7 TAF3 TAF10 PMC10500222__F6 CELF2 is the upstream regulation factor of MAPK signalling pathway, PI3K/AKT signalling pathway, autophagy and ERAD pathway, which can promote cancer cell ferroptosis through these pathways PTEN NFATC1 PREX2 ATG5 CELF2 PMC7994620__F4 Activation of cyclic AMP pathway through various genetic defects in adrenocortical tumors and hyperplasias GNAS PDE11A PRKAR1A PRKAR1B PMC10928970__F1 BRAF gene signaling pathway ARAF EGF EGFR BRAF HRG PMC3494542__F3 TGFB non-canonical signaling pathway CDC42 ARHA RAC1 CTNNB1 PMC5547956__F6 Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease MAX ECSIT JUN FAS EGFR CD14 TNF TRAF6 DAO FLNA MOS NLK GRB2 TRAF2 PMC5547956__F7 Synopsis of significant mitogen-activated protein kinase (MAPK) signaling pathway in the dentate gyrus (DG) of mice exposed to MPTP according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis MAX ECSIT EGF JUN FAS EGFR BAP1 CD14 TNF TRAF6 FLNA NGF GRB2 BDNF TRAF2 PMC4319670__F1 Insulin signal transduction pathway SNAP23 PI3 PTEN IRS1 PMC6029073__F1 Schematic diagram of the Sho1-dependant branch of the yeast high osmolarity glycerol (HOG) pathway as a model system for analysis of short linear motif function in signal transduction CDC42 NUP133 PMC5260495__F8 A schematic diagram shows that CD9 binds to gp130 and stabilizes gp130 by blocking its ubiquitin-dependent lysosomal degradation to promote the BMX-mediated STAT3 activation in GSCs STAT3 CD9 GSC BMX IL6 PMC6029073__F7 Examples of well-characterized signaling pathways contain numerous predicted short linear motifs APC LRP5 LRP6 HEL-S-64p CTNNB1 PMC10934027__F6 Metabolic pathway of terpene biosynthesis IPP MVP MVD MVK PMC5468443__F1 mTOR Signaling Pathway TSC1 PDPK1 PTEN IRS1 PMC6747043__F3 Endoplasmic reticulum (ER) stress-mediated inflammation ATF4 EIF2A XBP1 TRAF2 PMC8517779__F1 Biomarkers for gastrointestinal adverse events related to thiopurine therapy PACSIN2 NUDT15 TPMT PMC7552614__F10 Representation of the TGFB, BMP, and WNT signaling pathways SMAD4 MTOR CTNNB1 PMC1409799__F4 MAPK signaling pathways MEA1 SELL OPA1 RET PMC3578480__F2 Molecular pathways associated with CPPs NOTCH3 TWIST1 PMC10572663__F2 Signaling pathways regulating EMT EGF JUN HGF SMAD2 APC DHH SMAD4 IHH MTOR CTNNB1 SNAI1 SHH SMO LEF1 TWIST1 PMC2855202__F3 Cross-talk between the hexosamine biosynthesis pathway, O-GlcNAc modification of proteins, signaling events downstream of insulin action, and glucose-induced adipocytokine secretion OGA OGT SP1 VAMP2 GSK3B PTEN PMC10572663__F3 Hypothetical contribution of EMT-like process to the pathophysiology of RA TES RUNX1 SMAD2 MMP3 MMP9 MTOR PMC10572663__F4 Hypothetical contribution of EMT to the pathophysiology of pSS TES TGFB1 COL1A2 SMAD2 ZEB2 MMP9 COL3A1 PMC3847504__F5 Schematic illustration of the correlation in mechanisms among detected parameters HMGB1 TLR3 TLR7 MYD88 PMC9935518__F7 Decision-making workflow for selecting treatment for newly diagnosed ER+/HER2- metastatic breast cancer patients AEBP1 CDK6 FOXO3A MTOR CDK4 PMC11858609__F6 Illustrates the MAPK and NFKB signaling pathways activated by pro-inflammatory stimuli such as LPS, IL-1, IL-26, TNFA, and PAMPs COX2 TLR4 PMC11858609__F7 Effects of bioactive compounds on periodontal bone remodeling BMP2 NFATC1 RUNX2 PMC11858609__F3 Illustrates the NFKB signaling pathway, highlighting the role of pro-inflammatory stimuli such as LPS, IL-1, IL-36, TNFA, and PAMPs, which activate receptors (TLR4, IL-1R, TNFR) to initiate intracellular signaling cascades TRADD TLR4 IRAK1 RIPK1 IRAK2 TRAF6 TRAF2 MYD88 PMC4465296__F1 Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer TIAM1 INA ETV4 PC MDM2 KRAS PMC4465296__F3 Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer TGFBR2 SHH TGFBR1 PMC7246929__F1 Extrinsic apoptotic signaling pathway TRADD TNF TRAF2 FADD PMC7774640__F1 Cartoon proposed model of thyroid-associated ophthalmopathy (TAO) pathogenesis CD40 IGF1 CD34 PMC7471609__F3 Metabolic map visualization for (A) redox and hydrogenases pathway, (B) pyruvate node that links glycolysis, incomplete Krebs cycle, anapleurotic pathway, and fermentative pathway, and (C) sulfur metabolism using the Escher tool POR FDXR PPIE MALL PPIH ME2 PC PMC8143163__F1 Impact of H2S on Obesity-Associated Metabolic Disturbances CTH pcap DAO PMC5493710__F3 Improvement of the reprogramming process and replacement of c-Myc by small molecules and chemical compounds WNT3A BMP4 TGFBR1 PMC11626610__F4 Genes from the Toll-like receptor signalling pathway remain differentially expressed 8 h post 4th dose in MAD cohorts CD40 TIRAP CTSK TLR9 CD14 IRF3 IRF7 TRAF3 TNF IRAK4 RAC1 MYD88 TLR1 TLR3 TLR4 PDC LBP FADD PMC3077244__F5 The proposed signalling pathway PTEN CTNNB1 PMC4092857__F3 Activation of the DNA damage response upon CDT exposure CDC2 BAX ATR ATRIP CDK2 ATM CDK4 PMC3876433__F1 Oxidative metabolism in cancer STAT3 VEGFC PIM1 MCL1 SRC GAB2 PMC5328987__F1 Type III IFN signaling pathway SOCS1 IFNL2 IFNL4 STAT2 IFNL3 USP18 IRF3 MX1 TYK2 IL10RB PMC6704952__F9 Proposed mechanisms involved in the increase of SMN expression induced by ERK inhibition in the spinal cord of severe SMA-like mice SMN1 PMC12174016__F2 Mechanism of therapeutic strategies targeting pyroptosis for AD GSDMD NLRP3 TXNIP TLR4 MAF PMC12174016__F1 Molecular mechanism of pyroptosis NLRC4 NLRP1 NLRP3 AIM2 PMC8712646__F1 Vitiligo: An Autoimmune Skin Disease and its Immunomodulatory Therapeutic Intervention CXCL9 CXCR3 IL2 JAK1 CXCL10 NOTCH1 PMC9124774__F1 Recent Advances in Dual PI3K/mTOR Inhibitors for Tumour Treatment TSC1 PTEN MTOR PMC7518314__F1 Overlap between immune-signaling genes that are associated with pollution and SCZ CRP TLR4 CD14 IRF3 PMC3828651__F2 Molecular events associated with tumor suppressor gene product-induced senescence or apoptotic cell death of tissue-resident stem/progenitor cells during chronological aging BAX ATM PTEN MYC PMC6562892__F2 PPAR (peroxisome proliferator-activated receptor) signaling pathway enriched of differentially expressed genes (DEGs) in the jejunum of broiler chickens LPL SLC27A1 EHHADH UBC CD36 UCP1 HEL-S-28 ACADL PLTP CPT2 PCK1 SLC27A4 PMC7554122__F3 TGFB2-Hepcidin feed-forward loop TGFBR2 HAMP TGFBR1 PMC8124305__F3 S-Nitrosylation in Tumor Microenvironment IFNG STAT3 CD48 FAS HGF MMP2 IL1A MMP9 SRC TNF CCND1 PMC3193469__F4 Simplified cartoons illustrating the components of the cullin–RING E3 ligases (CRLs) RBX1 DDB1 CDC20 APC SKP1 APC2 PMC4355029__F4 RNA toxicity leads to activation of NFKB pathway HEL-S-162eP RELB BIRC2 PMC7376907__F1 Macroautophagy and mitophagy ATG101 UVRAG MTOR OPTN ATG5 PMC5073094__F2 Stimuli for degranulation of mast cells and basophils and interplay/overlap with type II-IV reactions NAT2 ALOX5 ITCH LTC4S XPNPEP2 DAO PMC7376907__F2 NLRP3 and AIM2 inflammasome pathways GSDMD NLRP3 AIM2 PMC7404091__F1 This figure summarizes the regulatory core of ferroptosis, approximately divided into three axes TF KEAP1 GPX4 ASCL4 LPCAT3 ALOX15 ATG5 PMC3193469__F6 Model of GA-induced DELLA protein degradation and the regulation of PIF protein function RBX1 SKP1 PMC3237253__F3 Adhesion of sickle red blood cells to the endothelium and cell activation CD44 CD36 BCAM VCAM1 CD47 PMC11576158__F2 Is choline kinase alpha a drug target for obesity? PPARG NR1C1 PRDM16 UCP1 SIRT1 PMC6930181__F2 Metabolic features of healthy and dysfunctional endothelial cells GLS ME2 HEL-S-162eP FASN MDH2 ARG2 PMC9149409__F7 Long Noncoding RNA MEG3-205/Let-7a/MyD88 Axis Promotes Renal Inflammation and Fibrosis in Diabetic Nephropathy AGO2 IL13 MYD88 PMC6155137__F8 GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway CDC42 RHO RAC1 PMC1698952__F4 Aspects of PRLR signaling as related to mammary gland function PRLR TEC PRL GRB2 SRC IRS1 PMC6836431__F1 mTORC1 and its signaling networks ULK1 GSK3B TTI1 PTEN HIF1A MTOR NOTCH2 DEPTOR RHEB MLST8 TSC2 TSC1 GRB10 ATF4 NOTCH3 NOTCH1 PMC10451996__F12 Mechanism by which fibroblast upregulation of VDR suppresses lung fibroblast proliferation and activation during pulmonary fibrosis NR1i1 STAT3 JAK1 PMC5655592__F6 Genes affected concordantly within the ileum and meta-analysis data sets formed biofunctional clusters of overlapping pathways CCR5 CTLA4 PMC5655592__F3 The antigen presentation pathway was downregulated in the GF mice CDC42 ALB HEL-S-99n PSMB3 HEL-S-269 PSMA4 PSMB10 PSMB2 TAP1 PSMA2 TAP2 PMC5655592__F4 Intraset concordancy and transcriptome-proteome discordancy of gene products related to protein translation, OxP, and chaperone proteins HSP90AB1 CANX RPSA HEL-S-310 RPL30 DNAJC2 TRIM21 EIF4E SDHD RPS16 ZNRF4 SDHB RPL39 RPS10 PLAT RPL17 RPS13 COX2 HSPA2 RPL27 RPL4 RPS12 REL PMC5715866__F6 Schematic showing the roles of EGFR ligands and NRG1 in the regulation of timing of ovulation and oocyte maturation ERBB3 NRG1 EREG EGFR BTC AREG PMC5779007__F7 HIF‐1A strongly associates with differentially expressed genes in rAAA VEGFC ANGPTL4 LOX CITED2 HEL-S-130P TNFAIP2 APOE BMP2 NTRK2 HAMP HILPDA FOS PMC8616463__F3 Global Reprogramming of Apoptosis-Related Genes during Brain Development POR BAX CAST CAD TRADD ATM REL TNF FADD PMC8643334__F1 Hepatitis B Virus e Antigen and Viral Persistence TNF IL1B PMC9018988__F1 Molecular Network of Colorectal Cancer and Current Therapeutic Options CDKN2A APC BRAF SMAD4 KRAS MGMT PMC5039366__F5 Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells HEL113 APC GSK3B RYK CTNNB1 PMC7106732__F2 Histone chaperone landscape of breast cancer metastasis FOXA1 DEK HJURP CCNE1 ANP32E PI3 NPM1 SKP2 PMC3172097__F1 Autophagy pathway in plants ATG10 ATG12 ATG14 PMC7318302__F1 Correlation of Notch signaling pathway and ER in breast cancer endocrine resistance MCAM EGFR HBD PMC8817240__F7 Sam68 contributes to intestinal inflammation in experimental and human colitis CSF2 RELA CCR2 CXCL10 TNF PMC7554194__F2 Other signals that regulate Schwann cell development P2RX7 CDH2 LPA P2RY1 P2RY2 APC ADAM22 ARHA GPR49 LGR6 PMC7554194__F3 Schwann cells integrate signals from the extracellular matrix (ECM) including mechanical forces, laminins and collagens GNAS DAG1 PMP22 ITGA6 EGR2 YAP1 PMC3799862__F5 Role of TRAF6 in RANK Signal Transduction Pathway MAP3K7IP1 TAB3 TRAF5 NFATC1 TRAF3 MTOR TRAF6 TRAF2 PMC6375727__F7 eIF2BE Constitutes a Pivotal Node between the Responses to Canonical Stress and Sema3ASema3A induces an initial (5 min) wave of local translation independent of the eIF2 pathway mediated by ERK-1/2 and mTOR EIF2B1 SEMA3A GSK3B ELF2 MTOR PMC4848607__F1 KEGG pathway analysis for the Toll like receptor (TLR) signaling pathway differentially expressed genes (DEGs) expressed in response to SAV-3 infection in TO-cells CD40 TIRAP CTSK TLR9 CD14 CPO IRF7 IL6 TRAF3 TNF TRAF6 IRAK4 MPL TLR3 LBP CD6 FADD PMC9040670__F8 Amino Acid and Fatty Acid Metabolism Disorders Trigger Oxidative Stress and Inflammatory Response in Excessive Dietary Valine-Induced NAFLD of Laying Hens FGF8A FAS ATF4 ASNS EIF2A PMC3573143__F2 Regulation of autophagy in response to stress RHEB TSC2 TSC1 ATG12 BNIP3 PTEN ATF4 MTOR EIF2A PMC4848607__F2 Summary of the Toll like receptors (TLR) and RIG-I like receptor (RLR) pathway genes based on upregulated genes shown in and excluding the downregulated genes shown in and TRIM15 IRF3 IRF7 PMC6700252__F3 Intrinsic intracellular signaling cascades of BDNF-TrkB and TrkB-A2a receptors PI3 GRB2 BDNF PMC5729535__F1 Extrinsic and intrinsic apoptotic pathways BAX APAF1 FADD PMC8427766__F3 COVID-19 Immunobiology: Lessons Learned, New Questions Arise CD80 TIRAP MAVS STAT2 IRF9 TAB3 CD14 IRAK1 IRF3 IL6 TRAF3 TNF TRAF6 CCL2 IRAK4 MYD88 STAT1 MAP3K7IP1 TLR4 TLR8 TLR7 JAK1 TYK2 PMC7457511__F9 Network analysis of DCAF subfamily genes WDR12 RFWD2 EED GSK3B AFMID WDR76 SIN3A GNB2 DTL PHIP DDB2 BRWD1 DDB1 CUL4A AMBRA1 PDHA2 FBXW8 TLE2 RBBP7 BTRC HDAC5 DET1 RPL10L DCAF5 DCAF15 ABCC11 FBXO22 CRBN PWP1 DCAF7 DDA1 DCAF1 LSM12 CSN1S1 TLE3 WSB2 ITLN1 ENTPD6 GRWD1 ACRV1 HCN3 WDR26 RNMT DCAF12L2 DCAF12L1 KATNB1 DCAF16 DCAF17 KATNA1 DCAF10 DCAF12 CCDC71 DCAF13 WDR59 CENPW DNAJC16 WDR57 NLE1 SMU1 WDR5B RNF220 PMC8427766__F4 COVID-19 Immunobiology: Lessons Learned, New Questions Arise TBK1 STAT1 MAVS STAT2 IRF9 IRF3 TRAF3 JAK1 PMC10453169__F5 Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma SHH SMO PMC4305100__F3 Interaction of HBV and TLR2/4 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC6275186__F2 Representative image of the participation of SARA in the TGFB signaling pathway PPIC EEA1 PMC10453169__F2 Schematic model of the canonical HH signaling pathway SUFU DHH SHH IHH SMO PMC4645345__F9 Proposed mechanism for SCG2 expression in HSV- and reovirus-infected cells SCG2 ARHA RHO PMC9454399__F5 Qingfei Jiedu decoction inhibits PD-L1 expression in lung adenocarcinoma based on network pharmacology analysis, molecular docking and experimental verification MIA BATF ICE1 TIRAP LAT POLI PTEN LCK GDA PMC7923165__F2 B-cell receptor signaling pathway is enriched in SYK targets in the DG75 Burkitt lymphoma cell line SYK BTK BCL10 BCR CD72 RASGRP3 GC CD22 BLNK CD19 LYN GRB2 PMC7264416__F4 Protein–protein interaction (PPI) network and pathway involving the survival-associated features GABARAP TH LEP TIRAP PATJ PCNA HEL-S-81p GEM LAT CD14 IRAK4 SET HEL-S-99n PDE3B HEXA C13orf34 UCN FGFR3 GRB2 CCND1 LBP PMC7923165__F3 Actin cytoskeleton regulation pathway is enriched in SYK targets in the MCF7 and MDA231 breast cancer cell lines HEL114 PXN F2 APC RHO INS DOCK1 PMC8979960__F7 Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease SPTLC2 SPHK2 SGMS1 CERS2 SMPD1 PMC2587278__F1 Oxidative and alkylation DNA damage is effectively repaired by the DNA BER pathway OGG1 TG EGR1 MPG NEIL1 HLF HIF1A PMC5650494__F3 Immune mediators in the brain and peripheral tissues in autism spectrum disorder RHEB PCDH10 TSC2 TSC1 PTEN EIF4E PMC8418145__F2 Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases CD40 PINK1 TFEB PMC5368188__F5 LIN28A/ZCCHC11 regulation of let-7 microRNA biogenesis, promoting cellular proliferation and modifying bioenergetics CCND3 LIN28B HMGA2 PIK3IP1 ATPAF1 HK2 DHFR CCNA2 CS MYC PAICS RICTOR TSC1 CDK6 LIN28A TK1 INSR CCND2 AK2 CRY2 IGF2BP2 CCNB1 CCND1 PMC5368188__F6 Transcriptional networks that regulate LIN28B expression LIN28B REST MYC SIRT6 PMC8408558__AF1 LINC01189-miR-586-ZEB1 feedback loop regulates breast cancer progression through Wnt/Beta-catenin signaling pathway DKK3 GSK3B LRP6 TCF4 DKK2 SFRP1 CTNNB1 PMC9381797__F1 Insulin signaling pathway was found to be associated with cerebrovascular pathologies in AD including inflammation, BBB disruption, and AB accumulation PGP GSK3B PTEN VCAM1 GRB2 PMC4830430__F4 Functional interplay between PPM1G and the transcription elongation machinery MEPCE LARP7 PPM1G ATM CDK9 PMC11688061__F7 Jak-STAT signaling pathway and related target expression, such as STAT TF HEL-S-133P IRF9 MTOR DAO VHL RBX1 TFRC GFAP TLR4 HEL-S-162eP PFKL JAK1 HEL-S-87p TYK2 PMC7880745__F7 Anti-metastatic Effects of Cationic KT2 Peptide (a Lysine/Tryptophan-rich Peptide) on Human Melanoma A375.S2 Cells JUN ARHA GRB2 PMC4868719__F7 Notch and Wnt/Beta-catenin signaling pathway play important roles in activating liver cancer stem cells WNT3A APC CCND1 HES1 PMC7537138__F4 SARS‐CoV‐2 and the possible connection to ERs, ACE2, and RAGE: Focus on susceptibility factors SRC ACE2 UNK PMC6472151__F1 The effects of thyroid hormones on the activity and expression level of eNOS in vascular endothelial cells PI3 PMC3251651__F4 Novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy SIN3A PCNA DHFR MDM2 SUV39H1 PMC5897396__F7 The proposed PTN pro-migratory signaling pathway that leads to CDK5 activation in human endothelial cells CDK5 PTN RAC1 PMC7884184__F2 The Keap1-Nrf2 signalling pathway in antioxidative stress-related radio- and chemoresistance TXN KEAP1 TFEB PMC7884184__F3 (1) The role of the PI3K-AKT signalling pathway in antioxidative stress related to radio- and chemoresistance RHEB TSC2 PTEN PMC9702353__F8 Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NFKB/NLRP3 signaling pathway GSDMD NLRP3 TNF PMC3249608__F2 RA-dependent non-transcriptional involvement in neurite outgrowth BAX BAD PTEN PDK2 MTOR RAC1 PMC5632457__F1 Predicted target genes of miRNA-34a in renal cell carcinoma pathway [KEGG hsa05211] JUN HGF TGFA PAK4 PTPN11 VEGFA EGLN3 VHL ARAF CRK SOS2 CREBBP EP300 GRB2 PMC3753703__F3 Alterations within the TP53 and RB1/E2F3 pathways in high-grade bladder cancer RB1 CCNE1 E2F3 MDM2 CCND1 PMC8025646__F1 Signals and molecules of pathological phagocytosis between microglia and target cell TREM2 HEL-S-62p SIRPA CD47 MERTK PMC8301007__F8 Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1Alpha-Sirt1 Pathway SIRT1 PMC6511634__F8 Schematic illustration for the potential mechanisms of PC4 in AIPC progression CDK6 CTNNB1 PMC9280721__F1 MTOR Signaling in Cardiovascular Disease to Target Acute and Chronic Inflammation MLST8 TSC2 TSC1 SGK1 TTI1 MTOR DEPTOR PMC11529026__F2 Smad-dependent and Smad-independent TGFB signaling in EndoMT CDH2 TGFBR2 SMAD2 SMAD4 TGFBR1 PMC4495377__F5 The flow of glucose carbons in the presence of added fructose in adipocytes MTHFD2 MTHFD1 MTHFD2L HEL-S-51e NNT PMC5578007__F2 Notch signaling modulates endothelial cells’ (EC) fate associated with neointimal hyperplasia NOTCH1 PMC4147035__F1 NFKB: A Coordinator for Epigenetic Regulation by MLL DOT1L HOXA9 RELA MEIS1 PMC6469758__F7 TLR2/4 signaling pathway mediates sperm-induced inflammation in bovine endometrial epithelial cells in vitro TLR4 IRF3 IL1B MYD88 PMC7753765__F3 Viruses join the circular RNA world TLR3 TRIM59 PMC3408195__F9 A novel KRAS-initiated pathway leading to the activation of VMP1 in cancer cells VMP1 KRAS GLI3 PMC5392402__F1 The workflow of PAIRS INA PTEN SET PMC3749885__F2 Pim kinase targets and their roles in inflammation and cancer SOCS1 ELF4 BAD SOCS3 PMC7016599__F2 Some of the signaling pathways regulated by integrin A6B4 in colorectal cancer cells MAX ITGB4 APC GSK3B BIN1 MYC CTNNB1 PMC8392871__F5 Novel Polyethylene Glycol-Conjugated Triazole Derivative with High Thyrointegrin AvB3 Affinity in Acute Myeloid Leukemia Management MMP10 LIF MPC1 SRC PMC8698607__F6 Comparative Proteomic Analysis of tPVAT during Ang II Infusion STAT3 UCP1 MTOR PMC6639052__F2 Proposed role of NEDD4 in IGF-1R signaling GRB10 NEDD4 IGF1 PTEN IGF1R IRS1 PMC5558474__F3 Impact of glucocorticoid on neurogenesis SGK1 DKK1 SMO CTNNB1 PMC8839902__F1 Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis SMAD1 DKFZp781O1323 SMAD2 MSC PTH RUNX2 CTNNB1 PMC7929780__F7 Canonical Notch signaling with points of intervention of current therapies ADAM17 ADAM10 NTM PMC2474948__F1 Integration of the TGFB1 apoptotic signal by the lipid oxidation end-product 4-hydroxynonenal TGFB1 SMAD4 ATF2 PMC8703169__F3 Mitophagy in Diabetic Kidney Disease SIRT3 TFEB BNIP3 SKP2 PMC8586418__F1 Recent Progress in Interferon Therapy for Myeloid Malignancies TBK1 STAT1 FAS CGAS STAT2 IRF9 IRF3 IRF7 JAK1 TNF TRAF2 TYK2 PMC8703169__F1 Mitophagy in Diabetic Kidney Disease UBR1 UBR4 PARL VCP PMC2916219__F5 A model for regulation pathways responsible for RN and AM symbioses NUP85 MYC PMC11979243__F3 Exosomes from different mesenchymal stem cells mediate apoptosis in brain cells after cerebral ischemia-reperfusion injury FOXO1 USP22 AIM2 DAPK2 MTOR SIRT1 PMC12149175__F0 Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway EGFR PIK3R1 PTEN MTOR PMC11988641__F1 MMP13 orchestrates dynamic remodelling of the extracellular matrix (ECM)’s physical properties LOX EGFR MMP9 PMC11520424__F3 STAT3 in HER2-positive breast cancer STAT3 EGF SRC PMC2901871__F7 Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis GEMIN2 GEMIN5 PHAX GEMIN6 GEMIN7 GEMIN8 PMC8795506__F9 Mesenchymal Stem Cells Overexpressing ACE2 Favorably Ameliorate LPS-Induced Inflammatory Injury in Mammary Epithelial Cells STAT3 TLR4 SOCS3 IL1B MYD88 PMC8988049__F7 Proteome-Level Investigation Into Plasmodiophora brassicae Resistance in Brassica napus Canola MYB ERF MYC PMC11520424__F2 Main STAT3 signal transduction pathways in breast cancer TF STAT3 EGF PIM1 EGFR PTPRC IL21R IL7R PTPRT MTOR SOCS3 DUSP2 CNTFR TRIM28 OSMR SRC GHR ERAS PMC10536292__F9 Theabrownin from Dark Tea Ameliorates Insulin Resistance via Attenuating Oxidative Stress and Modulating IRS-1/PI3K/Akt Pathway in HepG2 Cells PCSK9 HMGCR FOXO1 FASN GSK3B LDLR GCK PMC10759256__F1 DMMIC derivatization-assisted liquid chromatography-mass spectrometry method for metabolite profiling of the glutathione anabolic pathway in esophageal cancer tissues and cells GCLM GCLC HEL-S-64p PMC6624737__F1 Simplified demonstration of decarboxylation events with associated position-specific isotopomers used in this study HEL-S-62p C2 PC PMC7546399__F9 Network diagram of the metabolic pathways regulated by XFZYD on d 3 and 21 GABRA2 GAD1 ARG1 GAD2 PMC4832872__F3 Inflammation in gastric cancer: Interplay of the COX‐2/prostaglandin E2 and Toll‐like receptor/MyD88 pathways CD44 STAT3 HMGB1 CCL3 SOX2 CD14 CD133 MYD88 PMC7082326__F1 Mitochondrial PTEN-succinate axis promotes P NLRC4 NLRP3 TLR4 CFTR PTEN IL1B PMC7333287__F9 PI3K-Akt signaling pathway influenced by XLGB RHEB EGF BAD EGFR RXRA GSK3B CDK2 BCL2 MDM2 GRB2 MYC PMC9667311__F2 Ultrahigh resolution MS1/MS2-based reconstruction of metabolic networks in mammalian cells reveals changes for selenite and arsenite action TH HEL107 SPOP PMC3868569__F10 TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans PMC3804348__F1 Regulation of lipid metabolism in glioblastoma and the therapeutic drug targets FAS IDO1 LDLR MTOR ABCA1 PMC6751266__F1 Overview of microRNA-27a biogenesis, highlighting key enzymes in miRNA biogenesis DGCR8 XPO5 DROSHA PMC6751266__F2 Brief conclusion of miR-27a in regulating cell signal pathways Panel gray, miR-27a can regulate Ras/MAPK/ERK pathway to active key gene such as c-myc EGF FBXW7 FOXO1 PHLPP2 SMAD2 GSK3B SMAD6 SMAD4 CTNNB1 PMC6896744__F1 Schematic overview of the WNT signaling pathway MMP7 TIAM1 APC LRP5 MMP3 LRP6 ADAM10 CTNNB1 PMC6466116__F5 Transcriptomic analysis of Fgf10+/− versus control P3 lungs in NOX suggests that reduced Fgf10 expression could lead to vascular defects GNAS MAPK1 HRAS BAD OMP ROCK1 EDNRA NPR2 MAP2 FGF10 DAO RAC3 PMC7533107__F1 TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation GSDMD TRPM2 NLRP3 TLR4 CXCL8 IL1B PMC6109817__F2 Cross-talk between oestrogen (ER) and epidermal growth factor receptor (EGFR)/insulin-like growth factor 1 receptor (IGF-1R) signalling pathway and cyclin-dependent kinase (CDK)4/6 function IGF1R MTOR CDK4 PMC5490640__F4 Ubiquitin enzymes in the regulation of T cell-mediated autoimmunity ZAP70 ICOS ITCH RELA AIRE FOXP3 SKP2 CYLD STUB1 PMC5490640__F5 Ubiquitination in B cell activation CD40 OTUD7B TRAF3 TRAF6 TRAF2 PMC6975291__F11 The proposed pathway for suppression of glutamate release by postsynaptic metabotropic NMDAR signaling to Panx1 PANX1 TRPV1 HEL-S-11 FAAH SRC PMC5490640__F6 Ubiquitin chains and ubiquitin enzymes in the TNF-induced NFKB and apoptosis pathways SHARPIN TRADD OTULIN RELA RIPK1 TNF CYLD TRAF2 FADD PMC5490640__F7 TRIMs in the regulation of the immune response TRIM56 TRIM25 TRIM6 TRIM65 PMC5490640__F3 Ubiquitin enzymes in the TCR signaling pathway ZAP70 ITCH USP9X PELI1 PLCG1 MAP3K7IP1 USP15 BCL10 OTUD7B USP18 RELA MIB2 PC MDM2 CYLD LCK PMC9581404__F3 Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases APC LRP5 LRP6 CTNNB1 PMC2895421__F2 Convergent signaling pathways where inflammation and metabolic signaling intersect along the CHIEF pathway SOCS1 PIK3CA TSC2 TSC1 IKBKB SOCS2 IL4 PTEN IL6 MTOR TNF PMC9581404__F2 Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases APC CTNNB1 PMC5458740__F1 ECM–cell communication is dictated by focal-adhesion players GSK3B MTOR SRC CTNNB1 PMC5604037__F6 Schematic overview of MYC-mediated metabolic pathways MTHFD2 CAD DHFR LDHB TYMS DHODH ADSL PAICS MME RPIA OMP MTR PFAS PFKM PMC5016689__F7 Proposed model for the impact of CCL2 on HDL internalization and cholesterol efflux and regulatory mechanisms in HCAECs CCR5 CCR2 CCR3 CCL2 PMC10376673__F1 Breaking Bad: Inflammasome Activation by Respiratory Viruses CGAS GSDMD NLRP3 PMC2668236__F2 Major pathway and inflammatory mediators of sepsis and its related conditions TF CD14 IRF3 VCAM1 TNF PMC10489316__F9 Details of KEGG pathways of Ras, PI3K-Akt, and MAPK signaling pathway CDC42 BAD SHOC2 LAT MAL RHO GRB2 DAO RAC1 PMC5009769__F1 Wnt pathway regulation of intestinal stem cells CD44 DKK1 APC GSK3B LRP5 LRP6 CCND1 WIF1 CTNNB1 PMC7509716__F1 Proposed mechanism for enhancing antigen‐specific immune response by the CS‐IONzyme‐based influenza vaccine CD40 CD80 JUN IL16 PMC5009769__F3 Wnt pathway regulation of intestinal stem cells RNF43 LRP5 ZNRF3 LRP6 GPR49 LGR6 PMC6232757__F1 Representative scheme of the presence of O-GlcNAcylation on glucose metabolism in skeletal muscle OGA OGT FH HEL-S-162eP IRS1 PMC5335506__F2A Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage ADAR EED KEAP1 SRP14 FLOT2 AAAS SPTA1 MYL6B BTAF1 TPR PSMD3 PSMF1 EMD CPSF3 EIF3F ABCD3 HEL-S-108 NAMPT DSG2 LBR PGAM1 NONO CD2AP EIF3C ADA PMC7011400__F5 Proposed model for the effects of BSZYD on HEMEC angiogenesis through the VEGFR-2-mediated regulation of the MAPK signaling pathway PCNA MMP9 CCND1 PMC10910758__F7 Therapeutics of endochondral ossification and FOP targeting NFKB signalling SMAD9 HMGB1 SMAD1 DKFZp781O1323 SOX9 ACVR1 TLR4 RELA MSC RUNX2 ID1 SIRT1 PMC10878139__F5 TGFB signaling pathway mediates the effect of the GR signaling pathway in the TM SMAD2 SMAD4 PMC10878139__F3 Cross-talk between glucocorticoid receptor and YAP/TAZ signaling pathways LATS1 LATS2 PMC10878139__F4 Cross-talk between glucocorticoid receptor and Wnt signaling pathways DKK1 APC ROR2 ARHA RAC1 AXIN2 SFRP1 CTNNB1 PMC11201249__F2 Schematic presentation of mTOR modulation pathways TSC2 TSC1 NPRL2 C16orf35 DEPDC5 MTOR PMC3974856__F2 Tolerogenic plasmacytoid DC CCR6 PDC TLR9 VCAM1 CXCR4 PMC10910758__F1 Simplified diagram of the canonical pathway and alternative pathway of the NFKB signalling pathway (Created with BioRender LTB CD40 TLR4 RELB TNF PMC2533023__F5 Response of A549 cells exposed to crocidolite TNFRSF10B SOCS2 NTRK3 IRAK2 SOCS3 MYC CXCL3 MAP2K6 PIM3 VGF TRIB1 HLTF TFAP2C TIPARP STX1A STX3A HRK SMARCA4 LIMA1 TNFRSF12A ADM PLAUR LYST TNF ATF3 PTHLH ING1 GADD45A KLF4 RGS2 FOXD1 HEL-S-103 VEGFC TNFAIP3 LHB GEM SPHK1 PTEN RUNX2 THRA RARA LATS2 BTG1 FST PPP1R15A GDF15 GREM1 AHR GADD45B IL11 BIRC3 CITED2 KLF6 CXCL2 STC2 PTGS2 IL6 BCL2L11 DDIT3 BCL6 PMC10910758__F4 NFKB signalling during chondrogenesis in endochondral ossification SOX9 IGF1 BMP4 BMP2 MSC BMP7 RUNX2 RAC1 PMC10910758__F6 Scheme of FOP pathogenesis and the involvement of NFKB signalling SMAD9 HMGB1 SMAD1 DKFZp781O1323 SMAD4 MTOR RUNX2 ID1 LPA SOX9 ACVR1 TLR4 MSC ENPP2 PMC8454549__F3 Regulatory Role of Retinoic Acid in Male Pregnancy of the Seahorse KRT18 TRPM2 CRABP2 CYP7A1 COL4A2 SHH COL4A1 FSHR PITX2 CYBB PMC7816290__F7 PPI network and Path-Act-Network analyses CDC2 KIF11 NUF2 NCAPG SMC3 KNTC2 TTK SI CENPE CENPU SMC4 PMC6540047__F6 BRO priming of NFkB target gene expression in the absence of virus IL15 CD40 CXCL9 TNFAIP3 CD69 C1R SDC4 TAP1 CCL5 CCL2 IL15RA TAP2 GBP2 NFKBIZ TFEC NOS2 CSF2 EGR1 LIF NAMPT IRF1 CXCL2 IRF7 RSAD2 IL6 TNF CXCL10 ERAP1 NFKBIA BMP2 CCL4 VCAM1 IFNB1 TNFSF10 HLA-A PMC6540047__F4 BRO modulation of RV-induced NFkB target gene expression TFEC NFKBIA NAMPT NFKBIZ PMC6540047__F5 BRO priming of interferon response pathway in the absence of virus GYPB IFNE TBK1 MAVS IRF9 RIPK1 IRF3 TRAF3 ISG15 PIN1 FADD PMC7583882__F1 Schematic summary of Sphingosine 1 Phosphate (S1P)/S1PR (G-protein-coupled receptor) agonist and antagonist signalling SPHK2 SPHK1 RHO PMC8615162__F2 Coenzyme Q at the Hinge of Health and Metabolic Diseases ETFDH ANO10 FXN MPV17 PDZD8 MFN1 BRAF DHODH HMGCR SUCLA2 PARL MFN2 POLG LDLR PMC5958474__F8 Oxygen sensors, VEGF pathway regulators and stem cell master regulators regulate DNA damage response gene expression in human tissues KLF4 VEGFC SOX2 KIT HIF1A VEGFA MYC CD34 VEGFB FLT4 POU5F1 FLT1 KDR PMC2810142__F9 Network diagram of Sp1-interacting proteins RB1 STAT3 RAD51 SP1 BRCA2 SKP2 CDK4 PMC8850363__F1 Immune and Metabolic Alterations in Liver Fibrosis: A Disruption of Oxygen Homeostasis? CXCL12 USP19 APOE HIF1A PMC7591658__F6 BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes BAG3 HSPB8 BAG6 VCP PMC5953448__F2 Breast cancer related pathways SHARPIN RBCK1 RNF31 PMC4778564__F3 Hepatitis C Virus and Autophagy ATG12 IRGM ATG5 PMC4778564__F4 Hepatitis C Virus and Autophagy MAVS ATG12 ATG5 PMC8721920__F1 Interferon Control of Human Coronavirus Infection and Viral Evasion: Mechanistic Insights and Implications for Antiviral Drug and Vaccine Development TBK1 CGAS MAVS IFIT1 TANK IFIT3 IFIT2 MYD88 STAT1 CD74 USP18 TLR8 CH25H TLR7 OAS1 OAS2 STAT2 IRF9 IRF3 IRF7 LY6E IFNAR2 IFNAR1 JAK1 TYK2 PMC9485831__F4 Biochemical and physiological insights into TRH receptor-mediated signaling ADRBK1 TRH GSK3B BRAF GRB2 SRC CTNNB1 PMC6020372__F2 Molecular mechanism model for lncRNAs involved in the tumorigenesis of human TNBC KDM5B SFN ARHA PMC9576167__F1 Platelets and tyrosine kinase inhibitors: clinical features, mechanisms of action, and effects on physiology TEC SYK BTK FYN COX1 PLCG2 LAT LYN PMC5362544__F1 The association between copper transporters and the prognosis of cancer patients undergoing chemotherapy: a meta-analysis of literatures and datasets ATOX1 ATP7B ATP7A PMC3552512__F3 Oncogenic signals regulate each stage of translation RICTOR POLI EEF2 MTOR MYC EIF4E PMC11077368__F11 Schematic diagram explains the mechanism underlying by which SP protects against colitis CGAS GPX4 FACL4 SLC7A11 CXCL10 PMC6265312__F1 Triggering receptor expressed on myeloid cells-2 (TREM2) in microglial survival and metabolism TREM2 SYK GSDMD IL16 APOE GSK3B PC ADAM10 MTOR CCND1 IL1B CTNNB1 PMC8775565__F6 Physiological implications and importance of both simple-type and composite-type GSKIP in Wnt signaling GSKIP CTNNB1 PMC3389182__F1 Transcriptome analysis of HeLa cells response to Brucella melitensis infection: A molecular approach to understand the role of the mucosal epithelium in the onset of the Brucella pathogenesis MAX MAP3K10 GADD45G MAP3K12 EGFR BRAF STK4 PLA2G5 MYC IKBKG MAP2K4 CHUK DUSP14 MAP4K3 JUN RASGRF2 RPS6KA4 MARK4 MARK1 RAPGEF4 CRK MOS SOS2 CASP3 NTRK1 DDIT3 MAP2K1 GRB2 GADD45A YWHAZ PMC5206486__F1 Domain structure of retinoic acid-inducible gene-I (RIG-I) MAVS IFNAR1 IRF3 IRF7 TRAF3 JAK1 TRAF6 TYK2 PMC8497755__F1 Metabolic Modifications, Inflammation, and Cancer Immunotherapy EGF EGFR B3GNT3 CTNNB1 ZDHHC3 PMC8497755__F2 Metabolic Modifications, Inflammation, and Cancer Immunotherapy ZDHHC6 STAT3 ZDHHC11 TLR4 NOD2 IRF3 MYD88 PMC8557192__F1 New biological triangle in cancer: intestinal microbiota, immune checkpoint inhibitors and antibiotics ZAP70 HEL-S-92n CD80 CDK5 PTEN JAK1 LCK PMC3856107__F3 Roles and signaling pathways of let-7 in hypoxia- and neural stem/progenitor cells (NSPCs)-induced angiogenesis AGO1 SMAD2 PMC5883109__F9 EH regulates PGN-induced inflammatory response in DCs TIRAP GSK3B IRAK2 TRAF6 IRAK4 MYD88 PMC7486640__F5 One of the possible mechanisms of MFSD to alleviate the damage of high glucose to podocytes LRP5 LRP6 TCF4 CTNNB1 PMC3836362__F6 Interaction between dietary protein and mechanical loading on skeletal muscle cell RPS6 EEF2 MTOR PMC7912811__F1 Gonadotropin releasing hormone (GnRH) receptor signal transduction in endometrial cancer (EC) EGF JUND EGFR GRB2 SRC FOS PMC11521822__F6 The angiogenic signaling pathway in lean vs ADIPOR1 ADIPOR2 TWIST1 PMC5571156__F7 Mechanism of QE action SMAD2 SMAD4 PMC7912811__F2 Signal transduction of the putative truncated GnRH-II receptor in endometrial cancer (EC) EGF JUND EGFR PMC7576257__F1 TRAIL signalling pathway BAX TRADD TRAF2 FADD PMC7054750__F1 Active integrin internalization and trafficking pathways PGC RAB11B PTPRF RRAS RAB21 PMC4383231__F1 Intracellular fatty acid metabolism LPL LPA HMFN0839 GPAT4 CD36 GPAT2 PMC3097115__F5 PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans SF3B1 RBM22 PUF60 CACTIN SF3A1 SF1 PPWD1 TFIP11 U2AF2 HTATSF1 LSM5 SART1 SNRPB2 LSM7 RNF113A BUD31 ZMAT2 SYF2 CPSF6 KIN RBMX2 RNPS1 SNRPA1 PMC4037811__F1 An Inside View: VEGF Receptor Trafficking and Signaling NRP1 SRC CD47 PMC8220148__F7 Using Network Pharmacology and Molecular Docking to Explore the Mechanism of Shan Ci Gu (Cremastra appendiculata) Against Non-Small Cell Lung Cancer BAX ERF JUN BAD FOS BIK CDK4 PMC8220148__F5 Using Network Pharmacology and Molecular Docking to Explore the Mechanism of Shan Ci Gu (Cremastra appendiculata) Against Non-Small Cell Lung Cancer FLT3 AURKA PIK3CA ADORA2A TNKS2 MCL1 JAK3 TYMS DAO MAPK14 ALK FGFR1 PRKCA MMP2 KDR SRC BCHE CA14 NR1i1 NOS2 CTSL SREBF2 MIF SHE HMGCR CHRM2 IL8RB RET CA4 CA7 AURKC NR1H2 TGFB1 PTK6 PGR EGFR NR1C2 MTOR NOX4 RORA TGFBR1 BTK CA12 NR3A2 CDC2 ACHE KIF11 PTGER2 NR1H3 PTPN1 KIT MMP9 NR3C1 RORC CXCR1 TNKS ACVR1 PTGES MAP2K1 PMC3737722__F7 Model of cell-surface regulation of HH signaling CDON PTCH2 BOC PTCH1 SMO GAS1 PMC3718318__F16 ROS in endoplasmic reticulum (ER) stress-induced cell death LPA FAS CD36 PMC4179633__F7 Lcn2 role as a negative regulator in NFKB-STAT3 loop activation in macrophages STAT3 TLR4 LCN2 PMC7210384__F1 MGP Promotes Colon Cancer Proliferation by Activating the NFKB Pathway through Upregulation of the Calcium Signaling Pathway MGP NFATC1 VEGFA PMC3228218__F1 HCG/MET signaling pathway CDC42 CRK BAD CDK6 HGF GRB2 RAC1 PMC8297977__F6 Transcription Factors and Methylation Drive Prognostic miRNA Dysregulation in Hepatocellular Carcinoma CDC2 BAD MMP14 SGK1 NPY1R RFX5 RASGRF2 FOXM1 ACAT1 FOXO1 SRC CXCR4 CYP3A4 PMC9686558__F3 Ameliorative Effect of Tocotrienols on Perimenopausal-Associated Osteoporosis—A Review RBX1 KEAP1 PMC7814560__F6 Possible mechanism of Sfrp1-attenuated AMI injury in aged mice DVL1 SFRP1 CTNNB1 PMC10950953__F4 Immune cells interacted with jaw stem cells by signaling pathways PIEZO1 SUFU SMAD2 APC MSC SMO SAMD3 DLX5 TNF RUNX2 CTNNB1 PMC10950953__F5 Cellular interaction of immune cells and stem cells in the jaw IF2B1 MSC CCL2 PMC6258005__F3 Mitochondrial Fatty Acid Synthesis is the puppet master of mitochondrial biogenesis NDUFB9 HEL-S-5 NDUFA6 FMC1 FES PMC5844827__F1 Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment CCL28 FCER1A GATA3 PMC9650488__F6 Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular docking POR BAX TRO JUN TGFBI MVP RELA AIDA PMC3772117__F2 Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway PRC1 CSK PMC5397988__F2 Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy BAX FAS PMC6309266__F3 Long (lncRNA) and short (miRNA) of it: TGFBeta-mediated Control of RNA-binding Proteins and non-coding RNAs TGFB1 MSH2 SMAD2 SMAD4 TGFBR1 PMC10530375__F3 Anti-Inflammatory Effects of Peripheral Dopamine WNT3A GSK3B CTNNB1 PMC8318647__F1 Therapeutic mechanism of traditional Chinese medicine monomers on neurological recovery after spinal cord injury BCL9 APC LRP5 LRP6 CTNNB1 PMC11813745__F1 Figure-Schematic illustration depicting the role of Phosphodiesterases in Endocrine system and associated diseases NACA2 CNP CXCL10 ACE2 CXCL8 PMC3020905__F6 Molecular Basis for Vulnerability to Mitochondrial and Oxidative Stress in a Neuroendocrine CRI-G1 Cell Line FTL ATF4 UBB PMC3149315__F1 Biosynthetic pathway of GSL and the CIRES procedure GAL B3GNT5 ST3GAL5 B3GALT4 A4GALT B4GALNT4 PMC7523373__F1 Structure of Bruton’s tyrosine kinase (BTK) and associated cross-linking signaling pathways TH SYK BTK BCR BLNK LYN PMC6092430__F1 The mismatch repair pathway MSH6 MSH2 MSH3 PMS2 PCNA PMC9027630__F2 Osteopontin in Microglia Biology: Current Concepts and Future Perspectives CDC42 CD44 RAC1 PMC7461113__F1 Notch signaling pathway MTOR FURIN CTNNB1 PMC4973429__F2 Involvement of AKR1B1 in pathophysiology AKR1B1 PMC10854592__F2 STAT3 signaling pathway: STAT3 activation is initiated by upstream activity including ligand binding by (a) cytokines (IL-6 and non-IL-6 family members), (b) growth factors (EGF, FGF, etc STAT3 c-fgr EGFR ARHA SRC CCND1 TWIST1 PMC7821787__F1 MTOR signaling pathway and Rapalog therapeutic mechanisms RHEB TSC2 RICTOR TSC1 PTEN MTOR DEPTOR PMC3875765__F7 Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway PDGFD PMC5722815__F6 BMP2 or BMP6 signaling enhances adipocyte function PPARG SMAD1 LEP DKFZp781O1323 ID2 RXRA FASN ID4 SMAD6 SMAD4 ID1 ID3 PMC9451491__F4 Yuan-Zhi decoction in the treatment of Alzheimer’s disease: An integrated approach based on chemical profiling, network pharmacology, molecular docking and experimental evaluation GRIN2B GSK3B IL4 SNCA VEGFA VCP KCNA2 MPO LTB4R GLRB MME IL18 APP IL8RB RET PMC7425726__F9 Proposed regulatory pathway for FGF2 mediated mesenchymal transition in human corneal endothelial cells HEL113 SP1 SP3 FGF2 PMC3312242__F1 Regulation of cancer stem cells by inflammatory cytokine networks STAT3 CXCR1 RELA PTEN CYLD PMC7457372__F6 Signaling pathway by which C2S NPs promote osteogenesis through an autophagy effect ATG3 ULK1 SQSTM1 MTOR CTNNB1 PMC10902128__F4 TGFB signaling pathway TRADD BCR SMAD2 APC SMAD4 TRAF2 FADD PMC7583994__F1 Rearranged in transfection (RET) receptor structure and its intracellular signaling pathway DOK1 STAT3 GRB7 GRB10 FRS2 PI3 GDF15 GFRAL SRC IRS1 PMC4716672__F3 Therapeutic Interventions to Disrupt the Protein Synthetic Machinery in Melanoma POLI PTEN MTOR TBP PMC4115620__F6 Pathway analysis for H3K9me3 enriched genes in baboon SVZ cells CDC42 HEL-S-133P COPS5 RSU1 EPO HEL-S-28 PTEN MMP9 MTOR VEGFA RHO NCK2 VHL SUMO1 HIF1AN RICTOR BMP2 ATM MDM2 LEF1 NACA PMC12076972__F5 KEGG enrichment results related to the potential targets of Gyp LI HPSE NR1C1 F2 EGFR KIT CDK2 VEGFA SRC PMC11944911__F6 D-LA biosynthetic pathway in engineered S GPD2 MPC1 GPD1 PMC3547636__F2 G Protein-coupled Receptor FPR1 as a Pharmacologic Target in Inflammation and Human Glioblastoma STAT3 EGFR FPR1 ANXA1 SRC CXCL8 PMC5067255__F7 Proposed model for the profibrotic regulation of GLUT1 expression by TGFB SMAD2 PMC7564075__F4 Signaling mechanisms of CD271 NTS JUN ROCK2 LIMK1 BRAF HEL70 ARHA TRAF6 NGF EZR RTN4R SORT1 NTF4 NTF3 ROCK1 NRAS GRB2 BDNF RDX PMC4147769__F2 Possible mechanisms of autophagy in mammalian cells ATG10 ATG3 ATG16L1 ATG12 PI3 ATG14 MTOR ATG5 PMC8058227__F2 Ecdysone production and systemic release in response to dietary nutrient availability TSC2 TSC1 SMAD2 PMC4263456__F8 Myosin II accumulation and contractility are governed by a mechanosensitive control system IQGAP1 PMC8392544__F4 Applying Bioinformatic Platforms, In Vitro, and In Vivo Functional Assays in the Characterization of Genetic Variants in the GH/IGF Pathway Affecting Growth and Development STAT3 STAT1 IGF1 IGF1R SOCS3 GHR PMC3774790__F8 Lmx1a Encodes a Rostral Set of Mesodiencephalic Dopaminergic Neurons Marked by the Wnt/B-Catenin Signaling Activator R-spondin 2 TH LMX1A POU4F1 PITX3 WNT1 CALB2 CTNNB1 PMC9276970__F9 Extracellular Nucleosomes Accelerate Microglial Inflammation via C-Type Lectin Receptor 2D and Toll-Like Receptor 9 in mPFC of Mice With Chronic Stress NLRP3 TLR9 CLEC2D IL1B MYD88 PMC5488012__F1 Role of ROS in VEGF-mediated angiogenesis STAT3 HIF1A SRC NOX4 PMC3298530__F7 Tentative scheme for luteolin regulation of the IGF-IR signaling pathway in HT-29 human colon cancer cells MDM2 CCNB1 CCND1 IRS1 PMC3260001__F1 Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells CDC42 CASP8 ROCK1 CPN2 PTEN RHO MDM2 GRB2 MTOR SRC PMC9681871__F2 SMAD-(in)dependent bone morphogenetic protein (BMP) signalling pathway (oversimplification) SMURF1 ARHA SMURF2 PMC4253420__F7 Prolactin induces up-regulation of its cognate receptor in breast cancer cells via transcriptional activation of its generic promoter by cross-talk between ERA and STAT5 PRLR SP1 PRL PMC4147769__F1 Simplified outline showing key proteins within the extrinsic and intrinsic apoptotic pathways in response to extra- and intracellular stress CASP9 CASP8 CASP3 FADD PMC8302405__F6 Network Pharmacology/Metabolomics-Based Validation of AMPK and PI3K/AKT Signaling Pathway as a Central Role of Shengqi Fuzheng Injection Regulation of Mitochondrial Dysfunction in Cancer-Related Fatigue TH FAS SP1 FER tmp_locus_29 NOG MAL KL PMC4223072__F11 Epithelial AvB3-Integrin Boosts the MYD88-Dependent TLR2 Signaling in Response to Viral and Bacterial Components SYK IL10 IRAK1 IL2 IRF3 SRC IRAK4 CARD9 MYD88 PMC1436036__F12 Core signaling pathway downstream from V2R occupation in IMCD AQP2 PDE2A AVPR2 ARRB2 MYH10 GRK4 GNAS MYLK PDE1C ADCY3 HEL-S-162eP STX7 RYR1 ADCY6 PDE7A PRKAR1B PS1TP5BP1 AVP PMC3623872__F5 Nutrigenomics in Arma chinensis: Transcriptome Analysis of Arma chinensis Fed on Artificial Diet and Chinese Oak Silk Moth Antheraea pernyi Pupae MAFK EIF4B FAS ELL BRAF HIF1A MTOR INS EIF4E RHEB TSC2 RICTOR TSC1 GRB2 PMC8914285__F3 New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases CCL19 TLR4 CCR7 IRAK1 IRAK2 VAV1 TRAF6 IRAK4 MYD88 PMC6694749__F5 PIKKs-related signaling pathway in the aging brain ATMIN ATR BRCA1 ATM NRF1 MDC1 SSB PMC155294__F4 Representation of the cell cycle control pathway within TIGR Orthologous Gene Alignment (TOGA) BAX CDK6 E2F2 E2F3 CDK2 BCL2 ATM MDM2 CDK4 PMC7573473__F4 BCL-2 family members and their role in the apoptotic pathway BAX BAD PMC7767993__F4 Key connectors of (A) T1D-bacterial infection in Wnt signaling pathway and (B) T2D-obesity in appendage morphogenesis WNK1 PSMB6 TCF4 MYC MAPK3 PSMD3 ADRM1 HDAC2 UBB PSMB3 PSMD7 SNX3 AP2M1 PSMC6 CALM1 PSAP EGFR PSMA4 PSMB2 PSMD2 VCP HEL-S-276 PSMD1 CTNNB1 TUBA4A APP CLTC PSMD6 YWHAG PSMD4 MOV10 HEL-S-72p HMGB1 MYOD1 PSMD11 UBC JUN PFN1 HEL-S-91n EGR1 SDCBP NEUROD1 NR3C1 LMO4 NFKB1 RELA SKP1 TRIM29 DDX3X LEF1 BCL6 YWHAZ PMC11945976__F4 Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact RPE XK XDH PMC6321037__F2 S100A10 plays a key role in regulating pro-tumorigenic processes including proliferation, adhesion, motility, invasion, metastasis, and therapy resistance S100A10 ANXA2 PLG PMC4858120__F5 EGFR, HER‐2 and ER with downstream the RAS/RAF/MAPK and PI3K/AKT pathway EGFR BRAF PTEN MTOR KRAS PMC9221026__F1 Translational Regulation in mTOR Pathway RHEB MLST8 TSC2 RICTOR TSC1 PTEN MTOR PMC9654823__F6 Equus Beta-Defensin-1 Regulates Innate IMMUNE Response in S. aureus-Infected Mouse Monocyte Macrophage SYK CCL2 IL1B PMC9221026__F2 Translational Regulation in mTOR Pathway EEF2K EIF4B LARP1 EEF2 EIF4E PMC10550586__F4 Representation of the KEGG TNF Signaling Pathway, showing up-regulated (red boxes) and down-regulated (green boxes) genes MMP14 LTA FAS CSF1 ITCH MLKL CXCL1 TAB3 TRAF3 NOD2 CHUK MMP3 ATF4 CEBPB IL1B JUN CSF2 SELE JUNB BAG4 VEGFD PTGS2 MMP9 CXCL6 TNF FOS RIPK3 NFKB1 EDN1 NFKBIA TRAF1 BIRC2 TRAF2 FADD PMC4835942__F1 Ca2+-mediated regulation of autophagy in the heart CASR IGF1 ULK1 TFEB MTOR ATG5 PMC9692129__F7 Spatiotemporal characteristics of P-selectin-induced B2 integrin activation of human neutrophils under flow SYK BTK PLCG2 RAP1A PMC7883293__F8 ESM1 drives PCa metastasis by coordinating with the Wnt/B‐catenin pathway APC GSK3B LRP5 LRP6 ESM1 TCF4 CTNNB1 PMC9143202__F9 Notch3-Mediated mTOR Signaling Pathway Is Involved in High Glucose-Induced Autophagy in Bovine Kidney Epithelial Cells ATG3 NOTCH3 PMC8647113__F9 Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases TH COMP MAK COPA SHE VILL PMC8987494__F3 PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? RHEB PTEN MTOR EIF4E PMC11902984__F1 Pro-apoptotic TRAIL signaling pathway BAX APAF1 FADD PMC11172074__F1 Effect of miR-21 on the PTEN/AKT Signaling Pathway EGFR PTEN GRB2 SRC PMC4377205__F4 Gene interaction pathway TES PKP2 PKP1 CS ABI3 ADA PMC3425856__F4 CO prevents inflammatory responses via inhibition of NFKB signaling pathway VCAM1 MYD88 PMC4788817__F6 Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia AQP4 TLR4 CRH CRHR1 PMC3388509__F2 Inflammasomes and Intestinal Tumorigenesis STAT3 STAT1 COX2 PMC9024123__F4 Network Pharmacology Analysis of Huangqi Jianzhong Tang Targets in Gastric Cancer PIK3CA CYCS GSK3B HIF1A MYC MAPK8 MAPK3 RB1 HMOX1 BIRC5 BCL2L1 PRKCA MMP2 ABCB1 MAPK1 CASP9 CASP8 SP1 VEGFA FOS YAP1 HRAS GSTM1 CDKN1A RXRA CDK2 BCL2 HEL-S-22 EGF TGFB1 PCNA GAS EGFR PTEN IGF1R MTOR CTNNB1 CCKBR NR3A2 TLR4 CCND1 TOP2A IL1B BAX JUN MMP9 PTGS2 KRAS CASP3 NFE2L2 ERBB2 HRH2 PMC1502529__F6 Network modeling JUP SHC1 AXL PXN VAV2 EGFR PIK3R2 PIK3R1 PTPN11 GIT2 HGS CBL PLCG1 FYN ERBB2 GRB2 PMC4067728__F3 Molecular actions of 1,25(OH)2D3 in inflammation and energy homeostasis in adipocytes NR1i1 TLR4 IL1B PMC11913854__F7 DHP-mediated apoptosis in HCT116 cells FAS WAS FADD PMC9514424__F7 Multiomic analysis of dark tea extract on glycolipid metabolic disorders in db/db mice IL15 LTB PGP LTA PC ARC AGA CYP4F8 PMC11057055__F5 Identification of microRNA (miRNA) target genes PPARG STAT3 SMAD1 WASF3 WNT3A NEK2 SMAD2 SMAD4 RGMA HIF1A CXCL8 ATP7A TRAF4 SPHK2 MMP2 NREP ZEB2 PDE4A NOTCH1 MAPK1 SNAI2 FBN1 SP1 MYH10 CTSK VEGFA FOS SKI RUNX3 VCAN YAP1 VPS35 IGF1 CDKN1A PLEC TP63 RP2 WASF2 ADAMTS2 COL5A2 LAMA3 GNA13 CXCL12 HGF EGFR PRKAG2 PTEN MTOR RUNX2 COL3A1 ITGAV TGFBR1 TGFBR2 TPM1 ACTA2 FXR1 COL1A1 TOPORS PHLPP2 MYH9 CCND1 CXADR IL10 THBS1 EGR1 COL1A2 ASPN TFAP2A PTGS2 FGF2 C1QTNF6 DKK3 FGF7 AGTR2 ARGLU1 FOXF1 ITGB1 NR2F2 SCN2A DIPLA1 GJA1 PMC4791802__F5 Transcriptome and metabolic flux analyses in the central carbon metabolism in ST687 and ST1 (non-producer) strains HEL60 PPIE ACO2 MAL AIP HEL-S-4 MPC1 GPD1 tal-1 HEL-S-68p FBP1 HEL-S-32 PPL PMC3856398__F3 Ras-dependent versus Ras-independent extracellular signal-regulated kinase (ERK) signaling LAT PAK1 LCK PMC8129499__F4 Coordinated Contribution of NADPH Oxidase- and Mitochondria-Derived Reactive Oxygen Species in Metabolic Syndrome and Its Implication in Renal Dysfunction NLRP3 PDC TNF IL1B PMC10821092__F1 Pharmacology of Veratrum californicum Alkaloids as Hedgehog Pathway Antagonists ADRBK1 SPOP KIF7 CDON MOS BOC SUFU SMO GAS1 GLI3 PMC4865099__F6 Cluster analysis indicates a potential pathway for MWCNT-induced fibrosis based on two distinct phases FCGR2B MMP12 HEL-S-62p CCL3 CCR5 CXCL1 ARG1 TNF CCL2 SPP1 MYD88 CCL14 IGF1 FCER1G PTGIR CCL17 PMC7641541__F2 CR2 site-targeted complement inhibitors CD59 FH CR2 CR1 PMC7641541__F3 Schematic graph showing that the complement system participates in the development of alcohol-induced liver disease C5AR2 CYP2E1 HEL-S-62p TLR4 PMC3471675__F6 Structural Insights into the Common Gamma-Chain Family of Cytokines and Receptors from the Interleukin-7 Pathway IL2RB JAK3 JAK1 PMC3985673__F5 Immune activation-related modules differentially correlated in NSCLC CD2 HLA-DOB CD72 RASGRP3 CR2 BLNK FAIM RORA ABCB4 RNF144A HEL162 ITK STAP1 PMC9318596__F2 Exploring the Role of Staphylococcus aureus in Inflammatory Diseases RIPK3 LTA GSDMD NLRP3 TLR3 MLKL TLR4 RIPK1 PMC6347688__F1 Social rank on blood cell gene expression and regulation vary by species and treatment according to two new studies in PNAS (, ) TLR4 GC IRF3 IRF7 MYD88 PMC12153588__F10 FGF downstream multiple signaling pathways LIMK2 LIMK1 MAP4 ARHA GRB2 PMC7136425__F8 Compound BA-5 inhibits HSCs activation through blocking both TGFB1 and LPS-induced NFKB signaling pathways and further inhibits macrophage recruitment and activation BAMBI COL1A2 TLR4 SMAD2 SMAD4 MYD88 PMC6397540__F1 Proposed model of cell signaling associated with the ALK5-SMAD2/3 tumor-suppressive arm identified by Monsivais et al TGFBR2 BMPR2 ACVR2B SMAD1 ACVR2A DKFZp781O1323 SMAD2 PMC4663246__F1 Cyclin D1-cyclin-dependent kinase 4/6-retinoblastoma 1 pathway RB1 CDK6 CDK4 PMC6544049__F1 Circadian rhythms and memory formation PER2 CRY2 CRY1 DBT PMC10125773__F5 TNFA signalling pathway CSA2 TRADD TRAF3 TNF TRAF2 FADD PMC4762924__F1 Key pathways of glycogen synthesis and metabolism PYGM PYGL GYS2 PYGB GYS1 AGL NUDT14 PMC10125773__F3 IL-1A and IL-1B synthesis and signal transduction pathways IL1R2 IRAK1 TRAF6 MYD88 PMC11522688__F9 Schematic illustrations of AMSC-EV and HUMSC-EV repairments on photoaging in vitro and in vivo via regulation of the TIMP1/Notch pathway (Created with BioRender TIMP1 MSC ADAM10 HES1 SIRT1 NOTCH1 PMC3596529__F1 Intrinsic control of axon regeneration TSC2 PTEN PDK2 MTOR PMC8066579__F4 RLR, TLR and JAK-STAT signalling pathways and interference of signalling pathways by structural and non-structural proteins of coronaviruses STAT3 MAVS STAT2 IRF9 TANK TRAF3 TRAF6 MYD88 STAT1 TLR3 IL2 TLR7 NPL TYK2 PMC6323178__F5 Compound K, a ginsenoside metabolite, plays an antiinflammatory role in macrophages by targeting the AKT1-mediated signaling pathway TBK1 TLR4 IRF3 SRC PMC3070659__F1 Representative axon regeneration-regulating pathways discovered in genetic model organisms CNTF PTEN SOCS3 FOS PMC8577691__F3 STRING analysis of habenular proteins with increased levels after (−)-menthol exposure COPS7A UBE3A AP1G1 PCBD1 TRAPPC1 TCP1 SPR CTPS2 ZNF547 CCT6A RNF123 PPP5C DNAJC5 BRAF TUBGCP6 TRAPPC13 ANAPC2 PSMD3 TUBA4A NF1 TPH2 GAD2 TAOK1 CETN2 FASN GLA PSMD7 SEC24C SEC31A PAICS NEDD4 PSMC6 HEL-S-87p DCTN1 NUDT2 PMC3889478__F1 Comparison of in vivo (left) and in vitro (right) signaling support to the intestinal stem cell EGF WNT9B WNT3 WNT2B PMC10982685__F1 Integration of Psat1 into glycolysis and the serine biosynthetic pathway and its contribution to additional signaling mechanisms PHGDH PSAT1 ATF4 PSPH PMC3153486__F5 Impaired Vascular Contractility and Aortic Wall Degeneration in Fibulin-4 Deficient Mice: Effect of Angiotensin II Type 1 (AT1) Receptor Blockade TRDN ACTA2 TNNC1 TNNC2 ASPH ATP2A2 ACTA1 TNNT1 TNNI1 ATP2A1 PMC7583347__F1 S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease KEAP1 GCLM NQO1 GC NRP1 PMC9704760__F5 An example paths-between query to find the two distinct directed links between two simple chemicals in the Urea cycle pathway with k = 7 NAGS ASS1 ASL OTC PMC8431939__F3 CD112R/CD112 axis: a breakthrough in cancer immunotherapy CD96 CD226 TIGIT PMC4434687__F4 Conversion of tabersonine to 3-hydroxy-2,3-dihydrotabersonine by the combined action of T3O and T3R enzymes MIA DIO1 MIA3 PMC4582117__F8 Schematic of the VEGF-A/NRP1 signaling pathway to promote cancer cell proliferation NRP1 ARHA PMC2671717__F7 Schematic Overview of Pyrimidine de Novo Synthesis, Salvage, and Degradation.Nucleotides synthesized de novo enter the nucleotide pool and become further converted to nucleic acids and other metabolic intermediates UPRT INS CP PMC8130408__F1 Nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway mediated by nicotinamide phosphoribosyltransferase (NAMPT) and circadian NAD+ oscillation NAMPT SIRT1 SIRT6 PMC11019464__F2 Chemoprophylaxis of precancerous lesions in patients who are at a high risk of developing colorectal cancer (Review) APC LRP5 LRP6 IMPACT CTNNB1 PMC3525723__F4 Insulin signaling transduction BAX BAD RBP4 MTOR PMC7251756__F1 Glucose Metabolism and De Novo Lipogenesis (DNL) in Adipocytes ACLY ACSS2 FASN CS PMC4326637__F1 Biology of Advanced Uveal Melanoma and Next Steps for Clinical Therapeutics TRIO PTEN RHO MTOR PMC3989634__F2 Myeloid differentiation primary-response protein 88 (MyD88)-dependent and MyD88-independent TLR-4 signaling pathway TBK1 HMGB1 IRAK1 IRF3 TRAF6 IRAK4 MYD88 PMC11809005__F3 Reconstruction of the ginsenoside biosynthesis pathway in PN flowers, with expression profiles of structural genes across the six developmental stages HMGCR MVD FDPS MVK PMC6723199__F1 The metabolic pathway of caffeine NAT2 CYP1A2 CYP2A6 CYP2E1 PMC4758349__F2 AIM2 inflammasome in infection, cancer and autoimmunity: role in DNA sensing, inflammation and innate immunity GBP5 STAT1 CGAS STAT2 IFNAR2 IRF9 IFNAR1 AIM2 IRF1 GBP2 IL1B PMC7566803__F7 IPA ATM-signaling pathway in (A) EFV treated MRC-5 and (B) A549 cells TDP1 MON2 JUN H2AX ATM MDC1 BLM PMC3359655__F1 Central IR/IGF-1 signaling PI3 GSK3B APP IRS4 PTEN IGF1R PDK2 IRS1 PMC4317318__F2 Immunologic synapse PTPN22 APC FOXP3 PMC8698755__F5 Exploring the Value of BRD9 as a Biomarker, Therapeutic Target and Co-Target in Prostate Cancer SOCS1 STAT3 PIK3CA RAF1 PIK3CD PIK3C2G JAK3 PIK3R2 PIK3C2A PIK3R1 SOCS2 SOCS3 MYC MAPK3 STAT1 PIK3C2B MAPKAP1 PIK3R4 STAT5B PIM3 SOCS5 AKT1S1 MAPK1 PIM2 STAT2 DEPTOR HRAS MLST8 RICTOR IGF1 BCL2 PIK3R5 PIK3R3 AKT3 BRAF PTEN MTOR PRR5 RPTOR PIM1 SOCS4 KRAS ARAF SOCS7 STAT4 JAK1 MAP2K1 MAP2K2 TYK2 PMC6040266__F7 Mitochondrial sulfide-oxidizing pathway HEL-S-62p RHOD ETHE1 PMC8422911__F10 cartoon illustrating the mechanisms by which deficiency of Adam15 leads to exaggerated COPD in mice CXCR3 ADAM15 MTOR PMC2173906__F7 Hypothetical scheme of the mechanism by which Dkk1 promotes osteolytic lesions in vivo WNT3A DKK1 BMP2 CTNNB1 PMC10177541__F9 Effects and mechanisms of SQSTM1/p62 on migration and invasion of HCC KEAP1 MMP2 MMP9 PMC4346117__F3 Evolutionary model of non-spatial clustered metastatic ovarian cancer ARNT2 WAC PMC8586976__F4 Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics BAX CDK2 BCL2 PMC7882715__F3 Possible mechanism of polymorphism influences related with MAPK and PI3K/AKT cell signaling CYP2C19 UST UGT2B7 PMC6740038__F3 The Keap1-Nrf2 signaling pathway RBX1 KEAP1 GSK3B SKP1 PMC7677104__F5 New, potential drugs targeting mainly immune cells, adapted and modified from Michalak SYK BTK HEL-S-171mP IL2 MTOR PMC5818881__F9 SYK and downstream kinases are essential to drive inflammation and blistering in experimental epidermolysis bullosa acquisita (EBA) SYK PLAUR FPR1 NCF1 PMC8584226__F3 Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases LPA PC MTOR PMC6740038__F1 The dual roles of Keap1-Nrf2 signaling pathway in pancreatic cancer RBX1 KEAP1 PMC6425516__F1 Epigenetic regulation of peroxisome proliferator-activated receptorA (PPARA) in fatty acid oxidation (FAO) genes (A–C) and PPARA signaling to the FAO metabolome (D) CD36 RXRA DKFZp666G145 HEL-S-11 SIRT1 PMC3103541__F8 Long-Term Continuous Corticosterone Treatment Decreases VEGF Receptor-2 Expression in Frontal Cortex CORT PTEN MTOR PMC9013863__F2 Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma SOS1 EGFR PTEN GRB2 MYC PMC9013863__F3 Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma RICTOR TSC1 SOX2 PMC2749675__F1 Scheme of the Wnt signaling pathway APC GSK3B LRP5 LRP6 NLK DAAM1 CTNNB1 PMC9013863__F4 Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma STAT3 BAX CDK6 BCL2 MDM2 CCND1 CDK4 PMC6696356__F7 Scheme summarizing the protection of AB25–35-induced SH-SY5Y cell mitochondrial dysfunction by ginsenoside Re via inhibits ROS/ASK-1 dependent mitochondrial apoptosis pathway and activation of Nrf2-antioxidant response pathway BAX GCLC MAF PMC7154970__F2 Regulatory roles of microRNAs in Tregs NCOR2 IFNG STAT3 STAT1 SMAD2 NFAT5 FOXP3 PMC6657153__F7 Schematic representation of Notch1-mediated regulation of Akt signaling disturbed by TDP-∆C protein PTEN HES1 NOTCH1 PMC4332439__F7 Interplay model of Wnt/Beta-catenin, LPS/TLR4, and growth factors in ENS TIRAP TLR4 APC GSK3B IRAK1 TRAF6 LBP IRAK4 MYD88 PMC4711038__F5 Altered gene expression in the JAK/STAT signaling pathway during diapause NOP56 PAIP2 PMC4711038__F9 Altered gene expression in the JNK signaling pathway during diapause TRAF4 HEL70 TRAF6 RAC1 PMC6740038__F4 Targeting Keap1-Nrf2 signaling pathway for pancreatic cancer prevention and therapy RBX1 KEAP1 GSK3B SKP1 CP PMC5179564__F7 Acetylation of central metabolic enzymes in desiccated embryos ACOX1 FAS HEXA FASN ACADVL ACADL ACACA ACADM FADD PMC6174285__F1 Cyclic nucleotides signaling pathway in plant cells GC PSIP1 PMC5551552__F5 Schematic summarizing findings and proposed mechanism of placental lipid metabolism in obese women TG DBP NR1C1 CYB DGAT1 ADFP PMC7825801__F2 Cholesterol synthesis pathway HMGCS1 HMGCR PMVK DHCR24 MVD DHCR7 IDI1 MVK PMC7411426__F2 Targets of hsa-miR-1307 CDC42 RAB10 BAD GSK3B MTOR PDK2 INS IRS1 RHEB TSC2 PDX1 TSC1 INSR FOXO1 FGFR1 RAB35 TAP2 PMC3762275__F2 Recognition of particulate and soluble Beta-glucans by dectin-1 and signal transduction in macrophages and DCs SYK NLRP3 IL16 PC IRAK1 SRC TRAF6 IRAK4 CARD9 MYD88 PMC7825801__F3 Fatty acid metabolism HTD2 FASN HEL-S-5 CPT1A PMC6323203__F1 Kyoto Encyclopedia of Genes and Genomes pathway analysis of differentially expressed proteins HEL-S-62p C2 APC ELL PMC12210502__F7 The molecular interactions and signaling pathways involved in the association between TSC and renal cell carcinoma development (by Figdraw) TSC2 TSC1 GPNMB TFEB PMC3590661__F1 Schematic overview of the impact of HDACi on DSB signalling, HR and NHEJ DNA repair pathways RAD50 RAD51 MRE11A BRCA1 H2AX BRCA2 ATM PMC12210502__F8 The molecular interactions and signaling pathways involved in the association between TSC and renal angiomyolipomas development (by Figdraw) TSC2 TSC1 PMC12210502__F5 The molecular interactions and signaling pathways involved in the association between TSC and diabetic kidney disease development (by Figdraw) MLST8 TSC2 TSC1 MTOR DEPTOR PMC12210502__F6 The molecular interactions and signaling pathways involved in the association between TSC and renal cysts and polycystic kidney disease development (by Figdraw) BAD PKD1 TSC1 FNIP1 PMC12210502__F3 The molecular interactions and signaling pathways involved in the association between TSC and acute kidney injury development (by Figdraw) RHEB TSC1 MTOR DEPTOR PMC12210502__F4 The molecular interactions and signaling pathways involved in the association between TSC and renal fibrosis and CKD development (by Figdraw) MLST8 TSC2 TSC1 MSC TRIM6 MTOR DEPTOR PMC4061041__F6 ATM Regulates Insulin-Like Growth Factor 1-Secretory Clusterin (IGF-1-sCLU) Expression that Protects Cells against Senescence EGR1 IGF1 ATM IGF1R PMC12210502__F1 Patterns of TSC1/2 role in kidney disease (by Figdraw) RHEB TSC2 PKD1 TFEB MDM2 FNIP1 FOXI1 PMC12210502__F2 TSC1/2 signaling pathway (by Figdraw) RHEB MLST8 TSC2 RICTOR PTEN MTOR DEPTOR PMC6437992__F1 ABT cell receptor (TCR) signaling pathway THEMIS ZAP70 ARHH PLCG1 SOS1 LAT APC VAV1 GRB2 TRAF3IP3 LCK PMC4285849__F1 Impact of IBD genetic polymorphisms on dendritic cell function IL10 ATG16L1 NOD2 PMC3078497__F1 Effector signaling pathways activated during ischemia preconditioning STAT3 BAD GSK3B PMC3133356__F7 Model showing the role for Bmi1 in the DNA damage response pathway BMI1 ATR BRCA1 H2AX RNF8 ATM SSB PMC8093290__F6 Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y12 signaling pathway VASP NLRP3 TLR4 IL1B PMC8699297__F2 Impact of a Faulty Germinal Center Reaction on the Pathogenesis of Primary Diffuse Large B Cell Lymphoma of the Central Nervous System CD79A PRDM1 CARD11 BLNK MYC MYD88 CDKN2A CBL BTK BCL10 BCR PAX5 TBL1XR1 PMC7797784__F6 Proposed mechanism of action of JC-5411 via activation of Nrf2 pathway against arteriosclerosis FAS NLRP3 KEAP1 GCLM GCLC LDLR CPT1A IL1B PMC5179308__F7 Pathway to muscle fibrosis depends on myostatin stimulating the differentiation of fibro/adipogenic progenitor cells in chronic kidney disease STAT3 SMAD2 FAP PMC3612022__F6 Proposed synergistic pathway to mitotic cell death in cells treated with a combination of paclitaxel and gefitinib or the PLK1 inhibitor BI2536 WEE1 PLK1 PMC2834195__F1 The circadian clock signaling pathway NPAS2 PMC10311893__F5 MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study NCOR2 DYRK2 TCF7L2 EDN3 IL18R1 RPL11 FOXO3A LEPR BMP2 TAP1 GHR NFYB PMC4511633__F3 Hypothetical model of insulin resistance development in response to nutrition overload INSR NOX4 IRS1 PMC4783088__F2 Regulation of hepcidin antimicrobial peptide (HAMP) expression TFR2 EBP GDF15 EPO HAMP HFE PMC5794012__F4 An overview of the main metabolic pathways affected by the storage lesion in RBCs during routine storage in the blood bank LAT MAL PMC12205195__F14 Comprehensive Genomic and Immunohistochemical Profiling to Predict Prognosis and Recurrence in Fertility-Sparing Therapy Based on Progesterone for Endometrial Carcinoma STAT3 NR1C1 LEP TRADD LEPR POMC NPY SOCS3 AgRP MTOR TRAF2 PMC4810129__F2 Effects of virus mediated targeting of PDZ proteins often converge on the PI3K/AKT signal transduction pathway LPA NHERF1 PDLIM2 PTEN SCRIB PMC12205195__F15 Comprehensive Genomic and Immunohistochemical Profiling to Predict Prognosis and Recurrence in Fertility-Sparing Therapy Based on Progesterone for Endometrial Carcinoma HBEGF JUN EGFR GRB2 MTOR SHE FOS PMC6166676__F1 Study design PTPN11 PMC8677728__F1 Targeting PI3K/Akt signal transduction for cancer therapy TBK1 ATR FRS2 EGFR PTEN IGF1R TRAF6 TSC2 TSC1 IGF1 BCR ATM GRB2 PMC11005958__F1 Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo HEL-S-92n PTN APC MYH9 CTNNB1 PMC8677728__F2 Targeting PI3K/Akt signal transduction for cancer therapy TSC2 MDM2 PMC8674309__F1 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment TBK1 CGAS MAVS TAB3 TLR9 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 STAT1 TLR4 IL18 TLR7 IL1B JUN IFNLR1 IRF9 IRF3 IL6 TLR3 IFNAR2 RELA IFNAR1 JAK1 TYK2 IL10RB PMC8674309__F2 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment IL15 IFNG CD80 CCL5 CCL2 PMC8674309__F3 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment STAT1 CD80 CGAS TLR3 STAT2 IRF3 PMC8674309__F4 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment IFNG STAT1 IRF9 IRF3 IRF7 PMC5539397__F1 Effect of RBBP5 inhibition on glioblastoma TBK1 TLR4 SOX2 PMC3023527__F7 Schematic summary of the results showing the consequences of mPGES-1 mediated PGE2synthesis for LPS-induced neuroinflammation IL16 TLR4 IL1B PMC11673720__F2 A-to-I editing in mRNA coding region resulting in missense mutation ADAR FLNB COPA ARHA MTOR PMC11673720__F4 Regulatory mechanisms of A-to-I editing on Alu ADAR MAVS ROCK2 ROCK1 ARHA PMC4396475__F11 Casein kinase 1A–dependent feedback loop controls autophagy in RAS-driven cancers BNIP3 MTOR PMC6627192__F4A Molecular Comparison of Imatinib-Naïve and Resistant Gastrointestinal Stromal Tumors: Differentially Expressed microRNAs and mRNAs UBE2C CDC6 EVI1 E2F7 CCNA2 RORA KIF23 SHCBP1 AHR CDKN3 UNK GINS1 JUN DOCK7 E2F8 JUNB PRR11 MARK1 TSC22D3 GMNN RBL1 CCNE2 MT2A NUSAP1 MCM10 GINS2 CEP55 PMC10178966__F3 Potential biotargets associated with the CI−AKI TET2 BAX SIRT3 NLRP3 TXNIP TLR4 IL33 HDAC9 PMC11430655__F1 Interaction network constructed for genes involved in central carbon metabolism in cancer (hsa05230) limited to Homo sapiens (https://genemania SLC3A2 ENO2 SLC7A11 SLC7A5 RUNX2 SLC25A1 PKLR HEL-S-133P SLC7A10 CLYBL ENO4 LDHB PPM2C PDPR hEMMPRIN HEL-S-30 ENOSF1 NAALAD2 NR2F1 RUNX3 PDP2 PGAM1 PGAM2 RUNX1 ENO3 AGER LAMA4 PMC11430655__F2 Graph representing the interaction network of AGER (the gene encoding RAGE) with genes encoding RAGE ligands S100A4 HMGB1 CAPZA2 EGFR S100A8 CYP4B1 MAPKAPK5 IRAK4 SFTPB S100A1 CAPZA1 ITGAM AGER NFKB1 RELA S100A12 S100B PMC5126201__F1 Adenosine pathway mediates immune suppression APC ADA PMC84078__F7 Schematic of the influence of Notch on MEF2C and myogenic bHLH factor interactions MEF2C MEF2D PMC5719258__F5 An integrated model for valve development EPHB4 GATA2 KLF2 EFNB2 CELSR1 SDC4 NFATC1 TBX5 PECAM1 CTNNB1 PROX1 FOXC2 UGDH GATA4 PMC7414235__F1 Gastrointestinal symptoms in patients with coronavirus disease 2019 (COVID-19) CCL25 MTOR ACE2 PMC10888452__F1 The PI3K/AKT signaling pathway and its activation TSC2 BAD TSC1 PTEN MDM2 TRAF6 PMC7933442__F1 Hypothetical model showing how alpha1-antitrypsin (AAT) may affect staurosporine (STS)-induced apoptosis and autophagy in NSCLC cells CAD F2 MTOR ATG5 STS PMC11430655__F5 Graph representing the interaction networks of selected genes DNMT3B SLC3A2 MCAM HELLS ENO2 SLC7A11 MTOR SLC7A5 PDK2 NAALAD2 NR2F1 RNF44 F8A3 TRIM28 PDK4 CBFB ENO3 SALL3 KLHDC9 DNMT3L ENO1 LAMA4 PKLR ZFP57 PMC3421232__F5 Network of 25 target genes and their interactive genes involved in regulating apoptosis and autophagy CASP9 PIK3CA BAD CASP8 TRADD CASP12 FASN ATG14 IRAK2 MTOR PIK3R4 CASP3 CASP10 FADD PMC7796313__F1 Therapeutic targeting of TGFB in cancer: hacking a master switch of immune suppression SMAD2 SMAD4 PMC11430655__F4 Graph representing the interaction network of Diaph1 with proteins involved in cytoskeletal dynamics HMGB1 VASP PFN1 SSH2 ERBB4 LIMK1 ACTA1 ARHA AGER SSH3 RELA SSH1 DIAPH2 PFN3 PFN2 S100A12 RTKN S100B HEL-S-15 DAAM1 PS1TP5BP1 PMC5328816__F6 A schematic representation of carbon metabolism in wine yeast, including glycolysis, pentose phosphate pathway and tricarboxylic acid (TCA) cycle HEL60 tal-1 GPD2 BDH1 ACO2 ENO2 HEL-S-68p ENO1 MDH2 HEL-S-26 GPD1 PMC9035535__F1 Gut Microbial Community and Host Thermoregulation in Small Mammals UCP3 TLR4 UCP1 SLN PMC6745797__F1 Major hallmark of immunosuppression in the TME through diverse pathways in EGFR-mutant NSCLC EGFR GSK3B AREG FOXP3 CCL2 PMC7796135__F1 Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis STAT3 STAT1 COX2 TNF PMC3508619__F1 MYC proteins and the p53/MDM2/p14ARFpathway BAX MDM2 PMC6745797__F2 Intrinsic cancer cell pathways mediate the regulation of PD-L1 expression and MHC in EGFR-mutant NSCLC MHC2TA EGFR GSK3B CDC37 MTOR MYC PMC8784548__F1 Emerging Therapeutic Strategies for Attenuating Tubular EMT and Kidney Fibrosis by Targeting Wnt/Beta-Catenin Signaling CRP MMP7 SIK1 APC GSK3B LRP5 FHL2 LRP6 CTNNB1 RSPO1 MAF MMP2 CFTR DOCK4 PMC9064286__F3 Determinants of tumor sensitivity to GLS inhibitors GLS KEAP1 PC SLC7A11 MTOR HEL-S-26 GATA3 PMC3213765__F12 Schematic of the sonic hedgehog signaling pathway SUFU SHH SMO PMC3089575__F8 Proposed interconnection between PE synthesis and conversion (PL interconversion triad) during LD biosynthesis TG PSD PEMT PC PMC3213765__F13 The sonic hedgehog signaling pathway in the primary cilium CCND2 SUFU SHH SMO CCND1 PMC7985832__F2 TREX1 dysfunction triggers the cGAS-STING cytosolic DNA sensing pathway TBK1 CGAS IRF3 TREX1 PMC3213765__F17 Wnt signaling pathway APC AXIN1 CCND1 AXIN2 CTNNB1 PMC11003766__F5 The BTN2A1-BTN3A1-BTN3A2 complex regulation DDOST ST6GAL1 DPM3 MGAT2 FDX1 DPM2 RFT1 ALG3 IRF1 CMAS DPAGT1 NANS SLC35A1 ALG5 ALG12 SRD5A3 GCS1 RPN2 DOLK MGAT3 ALG13 DPM1 RPN1 FES B4GALT2 NARF HSCB NUBP1 NFU1 GMPPB NANP FDXR FXN MAN1A2 ISCU MAN1A1 ST6GAL2 HEL-S-62p ALG9 RER1 MAN1B1 ABCB7 CIAO1 GANAB MAN2A2 MAN2A1 MGAT5B MGAT5 MGAT1 MPDU1 MGAT4C MGAT4D LYRM4 DOLPP1 MGAT4A MGAT4B CTBP1 STT3A ZNF217 B4GALT1 TUSC3 ALG8 RUNX1 GNE ALG6 ALG10 C2 ALG1 BTN2A1 STT3B PMC6996360__F3 Genes involved in hedgehog, Wnt, TGF‐B, and p53 signaling pathways were differentially expressed during developmental BA SUFU APC PTCH1 SHH SMO PMC4298325__F6 A, Diagram of the prostaglandin synthesis pathway including relative expression values (arbitrary units) for synthetic enzymes and receptors from our previously reported microarray analysis of bovine growth plate chondrocytes () COX1 PMC3361623__F3 A New Framework for Understanding IRES-mediated Translation DENR EIF2D EIF2A PMC6996360__F2 Genes involved in Wnt, PI3K‐Akt, MAPK, TGF‐B, microsatellite instability, and p53 signaling pathways were differentially expressed during developmental BA CASP9 MSH6 DCC BAD MSH2 SMAD2 APC CASP3 SMAD4 BCL2 RHO CTNNB1 PMC3361623__F1 A New Framework for Understanding IRES-mediated Translation EIF4B EIF4H EIF5 ELF5 ELF3 PMC8971815__F2 Intestinal Fibrosis in Inflammatory Bowel Disease and the Prospects of Mesenchymal Stem Cell Therapy SMAD2 GSK3B SMAD4 CTNNB1 PMC4536527__F8 Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1A pathway in chondrocytes TLR4 HIF1A IL1B PMC10526873__F1 G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology EGF HBEGF EGFR SRC TNF PMC12035766__F1 Brief diagram of the mechanisms of molecular hydrogen BAX TLR4 ATF4 FOXP3 TRAF6 XBP1 PMC10526873__F2 G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology KLF2 EGFR ARHA SRC MEF2C PMC4569588__F4 Exploring the Altered Dynamics of Mammalian Central Carbon Metabolic Pathway in Cancer Cells: A Classical Control Theoretic Approach ATR PIM2 RET PMC4320069__F1 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants KLF4 MLPH SKIL VGLL3 KLK3 TBX5 MAP2 FGFR2 NKX3-1 SOX9 SP4 KLF5 IRX2 MAP2K1 KCNJ2 PMC8318284__F1 Network analysis of 12 miRNA-mRNA interaction pairs associated with OS in EOC patients EMP1 ATF3 POSTN HBEGF CH25H PROCR NAMPT HBB PMC3539150__F1 Schematic diagram illustrating the specific cascade and signaling pathway in LPS-primed macrophages stimulated with MSU, silica, or alum salt crystals IL16 PIR IL1B PMC4320069__F4 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants NKX3-1 MSMB TMEPAI CLDN11 NGFR ITGA6 KLK3 TERT FGF10 URI1 PMC12035766__F3 Molecular hydrogen alleviating IBD and intestinal injury IFNG GSDMD APC ATF4 XBP1 PMC4320069__F2 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants KLF4 MSMB MMP7 GATA5 KLK3 TERT FGF10 MYC FGFR2 NKX3-1 SOX9 CLDN11 ITGA6 KLF5 LEF1 PMC12035766__F4 Molecular hydrogen reducing intestinal I/R injury TF GSDMD IRAK1 PTEN IRAK4 PMC4320069__F3 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants MLPH NKX3-1 MSMB MMP7 MDM4 SKIL CLDN11 TCF2 KLK3 TERT FGF10 BIK PMC12035766__F5 Molecular hydrogen inhibiting CRC growth RHEB TSC2 TSC1 PMC2798195__F9 Proposed mechanism for pathogenesis due to H TLR1 TLR4 CD14 PMC6534778__F2 TLR4 signalling in hypertension and potential therapeutic targets TBK1 TLR4 TAB3 IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 IL1B MYD88 PMC5469213__F2 Tuberous sclerosis complex and mTOR pathway RHEB TSC2 TSC1 PMC6406290__F10 Scheme of proposed IS-induced apoptosis via ROS-NRF2 and MAPK signaling pathways in human astrocytes DUSP5 DUSP8 ROS1 PMC11834690__F1 Production of insulin and the classical insulin signaling pathway RHEB TSC2 TSC1 PTEN PMC7824062__F1 Competition of 2-OBA and Pyr in the l-threonine-overproducing E NR1A2 THRA PMC8766339__F7 Case Report: Differential Genomics and Evolution of a Meningeal Melanoma Treated With Ipilimumab and Nivolumab STAT3 SDE2 SF3B1 TRIO EIF1AX KPG_011 ARF6 PTEN TERT MTOR RHO YAP1 CTNNB1 LATS1 LATS2 AMOT PMC3213765__F20 Shh and BMP signaling ID2 ATOH1 SHH MB ID1 PMC2063755__F1 Signaling events during EMT HDAC1 CRK FOXC2 SMAD2 MTA3 GSK3B HEL-S-28 SRC HDAC2 LEF1 CTNNB1 PMC8781887__F1 Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond PCK2 CLP1 FBP1 ATF1 PCK1 PMC4887211__F9 Proposed working model for Fbxo21-mediated innate antiviral response NEDD8 RBX1 FBXO21 SKP1 MAP3K5 PMC5234836__F5 Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway TGFA IFI6 PARP14 PLSCR1 LGALS3BP IRF9 IFIT1 IFITM1 IFIT3 DTX3L IFIT2 SP110 IRF7 RSAD2 OAS3 XAF1 OASL MX2 MX1 ISG15 OAS1 OAS2 EIF2AK2 PMC4706383__F8 The proinflammatory role of HECTD2 in innate immunity and experimental lung injury TLR4 GSK3B PIAS1 TNF PMC8855927__F1 Itaconate, Arginine, and Gamma-Aminobutyric Acid: A Host Metabolite Triad Protective Against Mycobacterial Infection MCC NLRP3 TLR4 IRF1 TNF PMC11017435__F1 NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease BAX FAS TRADD FADD PMC9261345__F1 NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction ATR SARM1 NAMPT ATM SIRT1 PMC6771568__F2 IGF signalling pathway alterations occurring in cisplatin‐resistant TGCT PIK3CA PTEN IGF1R PMC10973144__F2 Protein glycosylation is closely interconnected with glycolysis and other metabolic pathways OGA OGT PGM3 STS PMC8033311__F1 Classical necroptosis signaling pathway initiated by the combining of TNF ligand and TNF receptor 1 TRADD MLKL FADD PMC10973144__F3 Pathological macrophages that promote inflammation or fibrosis have altered metabolism as a results of lung injury STAT3 CHIT1 NEU1 CD14 PMC6755353__F1 The endosomal Toll-like receptor 7 (TLR7) in remodelling of the infarcted heart HMGB1 IRAK1 TLR7 IRAK4 IL1B MYD88 PMC5321214__F1 Coupling of toxic and pro-inflammatory lipids and innate immune response CD36 TLR4 MYD88 PMC12230849__F4 MiRNAs regulate the proliferation and migration of VSMCs KEAP1 MEF2C CTNNB1 PMC12230849__F5 Factors influencing VSMC apoptosis and their signal pathways IGF1 MCL1 TRAF6 APAF1 PMC12230849__F6 Autophagy in VSMCs and its influencing factors DUSP5 TFEB TRPV1 ATG14 ATG2B MTOR ATG5 PMC11701794__F2 CEMIP affects the PI3K/AKT, EGFR, and Wnt/B‐catenin signaling pathways, which contribute to cancer progression by promoting cancer cell growth, angiogenesis, and proliferation, while also inhibiting cell death SEMA3A EGFR CEMIP SLC7A11 NR1C2 ASCL2 PMC4891345__F1 Genes and biological processes shared in Parkinson’s disease (PD) and cancer PINK1 LRRK2 COX2 SNCA PTEN MTOR PMC11701794__F3 CEMIP‐related hyaluronan (HA) degradation occurs through rapid vesicle endocytosis CD44 EGFR HAS1 HAS3 CEMIP HAS2 HYAL2 PMC3982925__F1 PGD2 pathway in alopecia COX1 COX2 PMC6397983__F12 The insulin-like growth factor system role in PMSC differentiation into the skeletal muscle PAX3 MYOG IGF1 SOX2 MTOR PAX7 IGF2 IGFBP6 IRS1 PMC4575611__F1 An outline of the inhibition of type I IFN signaling pathways by viral proteins of KSHV CGAS TLR3 TLR4 TLR9 IRAK1 IFI16 IRF3 IRF7 TRAF3 TRAF6 MYD88 PMC3683896__F2 Extrinsic and intrinsic pathways of apoptosis APAF1 FADD PMC7959785__F2 Biosynthetic pathway of selenoprotein translation GPX4 SEPSECS SEPHS2 PSTK GPX1 PMC7924631__F1 Overnutrition leads to increased gluconeogenic gene expression by altering gut microbiota and lipopolysaccharide (LPS) production FOXO1 TLR4 CRTC2 CD14 XBP1 PMC7722981__F2 Type 1 diabetes mellitus as a disease of the Beta-cell (do not blame the immune system?) STAT1 PDX1 TLR3 TLR4 TLR9 IRF1 CXCL10 IL1B MYD88 PMC7924631__F2 IRS acetylation by abnormal cytoplasm-appearing P300 causes insulin resistance FOXO1 CRTC2 INS IRS1 PMC5385611__F1 Cell migration induced by EGF via regulated alternative splicing of the Rho GTPase Rac1 EGF EGFR SPSB1 RAC1 PMC5743619__F1 Schematic presentation of different pathways involved in PCa disparity.1 STAT3 EGF IL10 IL6 MTOR PMC4527420__F1 A simplified representation of endocannabinoid synthesis and degradation pathway DAGLA DAGLB COX2 PC FAAH PMC10943956__F2 SASP regulation of aging intervertebral disc cells converges on the p53/p21 and p16/Rb pathways TBK1 TSC2 CGAS TSC1 H2AX ATM PTEN SSB PMC11500330__F3 Radiation-induced skin fibrosis and OS SP1 SMAD2 SMAD4 NOX4 PMC2734563__F2 Possible mechanisms of UbcH7 regulation of Chk1 levels sand S phase BARD1 MCM7 BRCA1 PTEN PMC7029350__F8 Both extrinsic and intrinsic pathways converge in the same terminal execution pathway, which is initiated by the cleavage of caspase-3 BAX TRADD FADD PMC3721230__F1 Mechanisms of action of lipopolysaccharide (LPS) as a sepsis inducer CD14 TNF MYD88 PMC7382779__F4 Functional Relationships by Gene Ontology (GO) Enrichment Analysis of Protein Regulation Networks and Phosphorylation Regulation Networks HEL-S-68p HEL-S-49 ENO1 ASTE1 PMC7029350__F6 Wnt signaling is regulated by the cytoplasmic Beta-catenin destruction complex, which consists of the core proteins AXIN, adenomatous polyposis coli, casein kinase 1, and glycogen synthase kinase 3 APC LRP5 LRP6 CCND1 CTNNB1 PMC4530250__F2 GDF-15 regulates signaling pathways essential for cardioprotection BAD ALK EGFR SMAD6 CTNNB1 PMC3729336__F1 Schematic overview of the kynurenine (KYN) pathway IDO1 KMO IDO2 PMC7029350__F5 Class I PI3Ks activated by receptor tyrosine kinases, such as epidermal growth factor receptor, can phosphorylate PI 4,5-bisphosphate to yield PI 3,4,5-triphosphate in the cell membrane BAD GSK3B PMC2733936__F1 Targeting the ASK1/MKK4/JNK pathway upstream of mitochondrial prodeath signaling BAX BAD TRAF2 PMC8634471__F2 Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer COX2 TLR4 EGFR GSK3B PTEN IGF1R PMC7156217__F9 Possible model for the CD40 signaling mechanisms CD40 TBK1 TRAF3 TRAF6 TRAF2 PMC6978796__F3 Roles of defective mitophagy in AD with a vicious cycle between them USP35 USP30 CDK5 USP15 OPTN PARP1 PMC6755251__F4 T-cell receptor signaling pathway IL10 CBL FYN BCL10 LAT IL4 ITK GRB2 DAO LCK CDK4 PMC6054540__F9 Regulation of hepcidin in breast cancer spheroids STAT3 BMP6 SMAD4 PMC6834141__F2 Simplified overview of the signaling pathways in the target cells presented in this review that are relevant for the development of a pharmacological therapy rationale STAT3 IGF1 LIF CCND1 FADD PMC7343963__F6 Construction of correlation network ZFP36 EGR1 ADRB2 FOS PMC3645912__F1 Induction and maintenance of IDO in dendritic cells STAT3 CD80 FOXO3A AHR FOXP3 PMC11948861__F3 Autophagy-mediated ferroptosis CDH2 SLC40A1 HPCAL1 ATG16L1 GPX4 DHFR SLC7A11 HIF1A MTOR WBP2 MARCHF6 ATG9A HEL-S-29 TFEB ATF4 ATG5 PMC11948861__F4 Autophagy-mediated other forms of RCD ATG10 HEL-S-99n HMGB1 WDFY3 ATG12 UVRAG APC MTOR ATG5 PARP1 PMC2780394__F7 The signaling network of differentially expressed proteins CDC42 BAD RELA CHEK1 PRKCA TP63 CDK2 CAMKK1 TFF3 CDK4 CTNNB1 PMC3206090__F5 Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development TSC2 TSC1 IGF1 GSK3B MTOR PSEN1 HTT PMC3206090__F2 Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development NGF HAP1 APP BDNF HTT PMC12223711__F3 Function of NDR1 and other NHLs in PTI and ETI responses RPS2 BAK1 PMC5629826__F1 Dopaminergic pathway genes and serotonergic pathway genes TH HTR1B DRD1 DRD2 DRD4 DRD5 HTR2A DDC DRD3 MAOA PMC3730337__F1 HDACi and DNMTi target the MM cell ATR APC ATM PMC2974943__F2 Intracellular signaling pathway within cranial neural crest cells mediated by endothelin-1 (Edn1) ECE1 ECE2 EDN1 FURIN PMC8204192__F4 Genome Analysis of a Verrucomicrobial Endosymbiont With a Tiny Genome Discovered in an Antarctic Lake C6 TK1 HEL-S-5 FES PMC8533927__F1 Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers KEAP1 KRAS YAP1 PMC8533927__F2 Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers ERBB3 AURKA FGFR1 ERBB2 IGF1R KRAS PMC11048239__F1 Flux-independent signaling pathways activated by AMPARs in neurons LYN ARC BDNF PMC8210594__F1 Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease CGAS RUNX1 KIT CTLA4 FOXP3 PMC6567134__F8 Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation TG APOA4 CD36 CIDEA FASN MOGAT1 LPIN1 CIDEC PMC4522390__F1 The Repeat Expansion Diseases: the dark side of DNA repair? OGG1 XPA RAD52 LIG1 FEN1 NEIL1 POLE PMC8353504__F1 Hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders NPY CPT1C AgRP CPT1A PMC5618525__F3 Signaling events downstream of IL7R (depicted in purple) and the pre-BCR (depicted in black and red) involved in the regulation of RAG1/2 expression and Ig light chain recombination CCND3 FOXO1 MCL1 JAK3 BCL2 IL7R RAG1 PMC6263343__F3 Heme biosynthesis CPO FECH UROD PMC11048239__F4 Flux-independent signaling by NMDARs in neurons PANX1 NOS1AP TRPV1 SRC PMC3682694__F1 Roles of molecules explained in this review in signal transduction ATR APC GSK3B PTEN MTOR SET CTNNB1 VHL RHEB TSC2 PKD1 TSC1 NF1 ATM PPA2 GRB2 PMC6274950__F10 Correlation networks of main potential biomarkers in response to T2DM rats CRP SOCS3 IL1B PMC8692454__F4 Reconstruction of the Rhodotorula frigidialcoholis major carbohydrate metabolic pathways mapped with transcriptomic data ACLY SDHB HEL-S-304 RPIA OGDH SORD PC DLD CS MDH2 XYLB SDHC PMC7794017__F1 Canonical and non-canonical WNT pathways MMP7 APC GSK3B LRP5 LRP6 RYK ARHA MYC CCND1 CTNNB1 PMC3243790__F1 Regulation of ABCA1 Functions by Signaling Pathways STAT3 IL6 TNF PMC2855687__F1 The kynurenine pathway with relevant regulatory components, summarizing gene expression and metabolite changes previously identified for schizophrenia in the frontal and anterior cingulate cortex TDO2 HEL-S-90n KYNU KMO HAAO MC5R MCHR1 PMC4135535__F3 Challenges in Vaccination of Neonates, Infants and Young Children CD40 BCR PLCG2 CD22 PMC2607114__F1 TFPI anti-coagulant and anti-inflammatory activities TF CAST TFPI LYN SRC PMC8228391__F1 Bilirubin: A Promising Therapy for Parkinson’s Disease SCARB2 PINK1 LRRK2 SNCA SMPD1 TNF PMC5844144__F1 Ferroptosis-associated metabolic networks IPP GPX4 LPCAT3 FACL4 ME1 ACACA PMC9657658__F2 Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells NOD2 NOD1 TRAF2 PMC3048826__F12 Signaling pathway of HMGB1-mediated ischemia reperfusion injury CDC42 HMGB1 IL10 TLR9 RHO SRC TNF RAC1 PMC7408018__F1 Autophagy pathway including the convergence of the endocytic pathway ATG101 LAMP2 ATG16L1 PIK3R4 ATG12 ULK1 ATG14 RB1CC1 MTOR PMC7520643__F1 Protein kinase B signaling pathway NQO1 PTEN PMC7300250__F1 Signaling pathways regulated by Shp1 STAT3 CDK6 CDK2 BCL2 SRC RAC1 CDK4 PMC2873801__F4 Relationships between differentially expressed miRNAs, putative target genes, and functions GLDC OTUD4 LY9 ASS1 GPHN TCEAL2 LAMA1 CLIC1 CTSH PLK2 DGIC AMPD3 IGLL1 PDE4DIP ALPK2 LDLR NNT SPRY1 NMI BATF ADM MMP10 MNT ATF3 ARHGDIB BCL2 NDP ELF3 PMC7408018__F2 ER stress unfolded protein response (UPR) pathways triggering autophagy ATG16L1 DDIT3 BCL2 ATF4 MTOR XBP1 PMC6858516__F5 Towards precision oncology in advanced prostate cancer RB1 CDK6 CDK2 CDK4 PMC9636677__F6 Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC CDC2 BAX HMGB1 BCL2 CCNB1 PMC6858516__F6 Towards precision oncology in advanced prostate cancer RB1 AURKA SOX2 EZH2 PMC6978262__F1 Signaling transduction pathways of regulating autophagy TRPM7 ULK1 MTOR PMC11055934__F1 Depicts the eicosanoid inflammatory pathway PTGIS COX2 GC CYP2C8 CYP4A11 EPHX2 PMC6858516__F3 Towards precision oncology in advanced prostate cancer FKBP5 PTEN PMC6858516__F4 Towards precision oncology in advanced prostate cancer MSH6 ATR MSH2 CDK12 PMS2 BRCA1 BRCA2 CHEK2 ATM PMC8468925__F3 Targeting the p53 Pathway in CLL: State of the Art and Future Perspectives ATR ATM PMC6858516__F1 Towards precision oncology in advanced prostate cancer RB1 CDK6 CDK12 BRCA2 CHEK2 ATM CDK4 PMC4791795__F2 Select Biological Pathways Significantly Associated with Differentially Regulated Genes EGF NGF LTA MAK NLK PMC11055934__F4 illustrates the various components of the p53 regulatory pathway and relevant polymorphisms associated with ISFO MMP2 WRAP53 MDM2 MMP9 TUG1 PMC2768529__F8 Proposed interplay between IL-15 and TNFA signaling in skeletal muscle CAD TRADD IL15RA TRAF2 FADD PMC4694985__F3 The respective drug targets in the overall architecture of molecular interactions for the top pathways correlating with response to Pazopanib A JUN RAD51 FASN PTEN MTOR IRS1 EIF4E TSC2 TSC1 ATM ATF4 CREB1 RET PMC11210914__F5 Mitophagy in ferroptosis PINK1 FTMT FUNDC1 PMC7744479__F2 Lymphoma induced angiogenesis in LNs and participating immune cells CXCL9 CXCR3 VEGFC LTA ELL MMP9 VEGFA FGF2 LTB CD44 CCL19 CCL21 IL16 CCR7 PMC11210914__F7 CMA- or TAX1BP1-mediated GPX4 degradation in ferroptosis HEL-S-72p LAMP2 GPX4 HEL-S-29 SLC7A11 SMPD1 MTOR PMC5217035__F7 Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling POR BAX PMC3936121__F7 MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family RRM1 MUC4 PMC3403823__F1 TLR-induced corneal inflammation TLR3 TLR4 TLR9 IRF3 TRAF6 MYD88 PMC8591223__F10 Low Expression of SLC7A11 Confers Drug Resistance and Worse Survival in Ovarian Cancer via Inhibition of Cell Autophagy as a Competing Endogenous RNA ULK1 UVRAG HIF1A MTOR STX17 RAB33B LAMP2 EIF2AK4 ATG12 NRBF2 RB1CC1 ATG5 ULK2 PMC8231924__F1 MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions ESAM MAGI1 ACTN4 RAPGEF1 AMOTL2 PTEN ARHA NET1 TRIP6 PMC2951022__F1 Toll-like receptor (TLR) signaling pathways ECSIT TBK1 TIRAP CD14 IRAK1 TLR5 IRF3 TRAF6 MYD88 TLR1 MAP3K7IP1 TLR4 RELA PMC3292584__F4 Differential gene expression in the TLR signalling pathway ECSIT JUN TIRAP CD14 TRAF6 FOS MYD88 LY96 TLR3 TLR4 IKBKB NFKBIA CHUK TLR7 LBP PMC5659172__F3 Trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase TXN HEL-S-62p C2 PMC7968485__F1 Ferroptosis: Regulated Cell Death GPX4 LPCAT3 FACL4 ADA PMC6978262__F2 Related miRNAs and target genes/pathways that regulate autophagy ATG10 ATG12 ATG9A BACE1 MTOR ATG5 SIRT1 PMC5630287__F6 Beta-NAD+ salvage pathway and PKC-mediated signaling influence localized PARP-1 activity and CTCF Poly(ADP)ribosylation CTCF NAMPT NMNAT2 NMNAT3 PMC2683584__F1 Control of Cell Number in the Sexually Dimorphic Brain and Spinal Cord BAX FADD PMC3675828__F3 Abundance distribution of cell cycle proteins APC APC2 ORC3 ORC2 POP1 PEF1 RBX1 RAD21 MRC1 RAD1 RAD17 SKP1 PPA2 PMC5876639__F1 Involvement of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) in DNA damage response pathway ATR ALK ATM MDM2 PMC7348182__F7 Results of RT‐qPCR and ELISA validation for cAMP and Rap1 signal pathway ADCY8 ADCY1 BLM PMC7148637__F40 RV regulation of the IFN amplification pathway STAT1 IFNGR1 IFNLR1 STAT2 IRF9 IFNAR1 IRF7 PMC8750433__F2 Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines IGF1 SMAD2 MTOR PMC4472122__F1 Signaling pathways activated by FGF/FGFR STAT1 FRS2 SRC PMC8489124__F5 Bai-He-Gu-Jin-Tang formula suppresses lung cancer via AKT/GSK3B/Beta-catenin and induces autophagy via the AMPK/mTORC1/ULK1 signaling pathway CYC1 APP PMC11210914__F1 Ferroptosis POR TFRC AIFM2 GPX4 MGST1 FACL4 NFE2L2 SLC7A11 DHODH PMC8798099__F4 Gene network screening of bladder cancer via modular analysis POR COMP KMO BRCA2 DAP TERT PMC11257964__F4 Targeting PANoptosis for cancer therapy RIPK3 GSDMD ZBP1 NLRP3 MLKL RIPK1 DFNA5 FADD PMC11257964__F1 Molecular machinery of apoptosis, pyroptosis, and necroptosis NLRC4 RIPK3 BAX FAS GSDMD TRADD NLRP3 MLKL RIPK1 TRAF2 FADD PMC3011268__F2 Regulation of Wnt signaling in Xenopus CNC C6 TRIO PTK7 PMC3253010__F3 A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype ICAM2 CAV2 HSPG2 AKT3 NRP1 SPARC PLXND1 JAM2 KCNB1 NID1 ARHGDIB NID2 FYN CD93 LAMA4 KDR PMC4830852__F1 Proteins encoded by genes analyzed in this study in the inhibition of the Wnt signaling SOX17 PPP2R2B DKK1 DACH1 CCND1 SFRP1 CTNNB1 PMC7139457__F1 Intrinsic apoptotic pathway and interactions between pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) family members BAX BAD BMF HRK BIK PMC4561407__F4 Translational control by ERK and mTOR EEF2 MTOR PMC3755409__F6 Scheme of the andrographolide regulatory pathway NRP1 KDR CCND1 PMC9437628__F4 System level modeling and analysis of TNFA mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets CAP2 CASP2 TRADD CASP3 TNF TRAF2 FADD PMC11050296__F10 Scheme showing the mechanism of olive-derived secoiridoids that regulate melanogenesis signaling pathway MC1R DCT CTNNB1 PMC6020395__F1 The vitamin-D metabolic pathway CYP2R1 CYP27B1 CYP24A1 CYP27A1 PMC8296701__F1 Genistein as a regulator of signaling pathways and microRNAs in different types of cancers STAT3 EGFR ATM MTOR KRAS PMC9437628__F2 System level modeling and analysis of TNFA mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets CASP9 CASP8 CASP2 TRADD CASP3 TNF TRAF2 FADD PMC3536145__F7 GXM-mediated inhibition of LPS-induced signal IL16 TLR4 MYD88 PMC11241568__F2 The JAK–STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia STAT3 STAT1 TSLP JAK3 JAK1 CRLF2 PMC4761208__F5 Pathway network of the 22 TSGs based on GeneMANIA BAX REST PLK2 APC STK4 PTEN FADD PMC5915057__F4 2’-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer CDC42 EGF ITGB4 TBXA2R PIK3R2 XBP1 PIK3C2B CACNA1H CDH11 SNN CD9 PDGFC MARCKSL1 NREP MEX3A TFAP2C KIAA1632 SOX4 APAF1 CSF1R JUP IL12A SELL CD14 DUSP4 PTK2B RAC1 FOS PECAM1 IRS1 S1PR3 GRB7 SORT1 ITGB1 IL24 NUAK1 TIAM1 EIF4E3 FGFR3 RRAS EMB GADD45A BCL6 PMC5915057__F5 2’-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer MMP16 POLD3 RNF4 PBX1 ELL CD133 TYMS MYC CCL2 BAG2 ETV6 NF1 AGL SMC2 CPT2 SPX HES7 PHYH ETV5 NR1i1 KIFC3 ABRACL ZNF703 ADAM19 HES2 IRX3 STK17B JUNB PRIM2 MIF PRIM1 FOS ZMAT3 COL18A1 POLA2 BTG2 AURKB MCM3 GINS2 ELK3 CYP4F3 KLF4 FDXR CDC20 PCNA EBP NFKB2 CENPE TGIF1 BLM XBP1 TPM1 CLU HEL-S-2a ATF4 CCND1 CEBPB MXI1 JUN CTH ID1 CCNE2 NFIB WWC1 DDIT3 RFC3 PMC6406640__F3 Schematic representation of gene silencing by siRNAs AGO4 AGO2 DROSHA PMC5690305__F1 Simplified metabolic pathway of thiopurines TG RAC1 TPMT PMC3478260__F4 signaling pathways triggered by L1CAM L1CAM HEL-S-28 SRC PMC5094313__F5 Metabolic pathways that may be affected by lactate flooding of brain after traumatic brain injury PC CIT PMC8122033__F4 CGAMP transport in the tumor microenvironment CGAS IRF3 SLC19A1 PMC8055391__F7 Follistatin-Like 1 Attenuation Suppresses Intervertebral Disc Degeneration in Mice through Interacting with TNFA and Smad Signaling Pathway IVD SMAD1 FSTL1 TLR4 BMP4 ADAMTS5 TNF PMC8616527__F3 Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease CDC42 POR FRMD6 RHO RAC1 PMC7478169__F1 Normal downstream pathway of TSC1 and TSC2, and its gene products RHEB MLST8 TSC2 TSC1 PMC9388335__F7 Inhibition of Kruppel-like factor 7 attenuates cell proliferation and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis through nuclear factor KB and mitogen-activated protein kinase signaling pathway KLF7 IL1B PMC3899964__F1 Discriminating Gene Expression Signature of Radiation-Induced Thyroid Tumors after Either External Exposure or Internal Contamination SMAD4 SULF2 CAMLG HEL-S-99n FRAT1 EREG WAS SHH MMP2 SMO PTPN18 EDN3 ID2 RNF11 ROR2 MED10 LRRFIP2 EZH2 OBSCN AREG ARHGEF3 ARHGAP19 ARHGAP12 AGGF1 SFRP4 ELMO1 UBE2B FOSL1 TNIK CHP2 CDC42 CXCL12 PLCB4 TGFA CDON EGFR RHO TGFBR1 PRKCE CLU TTN WWOX FZD1 GAS1 RRM2 FZD7 ARHA MED1 CD44 SF1 MFAP2 FRAT2 NOTUM HEL-S-102 NLK LYN ARHGAP10 PMC6273696__F30 mTOR signaling pathway was regulated by vancomycin in HK-2 cells RHEB RPS6 RHD TSC2 EIF4B TSC1 INSR PC MTOR ELF3 EIF4E PMC3407412__F3 Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles SPN CD226 CD40 TH ICOS CD80 CD2 APC CD22 PTPRC CTLA4 CD6 PMC3407412__F5 Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles BAD VASP HEL-S-28 PTEN ARHA SHE PMC2547860__F6 Networks among genes involved in milk fat synthesis DGAT1 VLDLR EPO FADS2 ACACA FADS1 ABCA1 INSIG1 ACSS2 BTN1A1 SPHK2 PPARGC1A ABCG2 LPL SCD FASN SREBF2 OSBP PPARGC1B ACSL1 GPAM THRSP LPIN1 SPTLC1 XDH PMC8957998__F8 Inspiration for COVID-19 Treatment: Network Analysis and Experimental Validation of Baicalin for Cytokine Storm TH MAFK MYL1 FRY KY MAK CS ME1 TNF TRAF2 PMC4174766__F2 Intracellular TLR signaling and trafficking in pDCs UNC93B1 TLR9 IRAK1 IRF7 TLR7 TRAF3 TRAF6 IRAK4 DOCK2 MYD88 PMC5549971__F7 Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses SIN3A NCOA1 RBBP7 KPNA2 HDAC1 NCOR2 SAP30 RBBP4 BRCA1 NCOR1 SAP18 EP300 HDAC2 SIRT1 KAT2B KAT2A PMC5686110__F2 Signaling pathway of breast cancer download from KEGG website– with targeted genes and pathways from germacrone, curdione, and furanodiene APC KIT REL PMC6365104__F1 Main regulation modes of copper transporters in human cells ATOX1 SP1 PMC6273696__F36 ER stress signaling pathway was regulated by vancomycin in HK-2 cells HEL-S-99n CASP9 CASP12 ATF4 XBP1 TRAF2 PMC6273696__F37 ERK-MAPK signaling pathway was regulated by vancomycin in HK-2 cells ARAF CRK BAD MOS PXN NFATC1 GRB2 SRC MYC DOCK1 EIF4E PMC5549971__F4 Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses NR1i1 EGF HEL-S-2 JUN LAMC2 MTOR ARHA KRAS FOS VCAN TRPS1 TPR ATF3 PLAT HPGD RELA NKX2-1 NFYA XDH GHR PMC6273696__F34 Remodeling of epithelial adherent junction signaling pathway was regulated by vancomycin in HK-2 cells HGS HGF RALA APC PMC6273696__F35 UPR signaling pathway was regulated by vancomycin in HK-2 cells OS9 CANX SEL1L BCL2 AMFR ATF4 XBP1 VCP TRAF2 PMC6273696__F33 Tight junction signaling pathway was regulated by vancomycin in HK-2 cells HEL114 CGN INA SAFB RAB13 STX4A PTEN CASK TNF PMC10520362__F3 Mammalian Intestinal Development and Differentiation—The State of the Art DKK3 FOXL1 RSPO3 BMP5 GPR49 WNT2B PMC5541263__F8 Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway TET2 RARB RXRA NUMB PMC6284756__F9 Regulatory effects of miR-1292 on hADSC senescence and osteoblastic differentiation FRAT1 APC LRP5 LRP6 LEF1 CTNNB1 PMC5701012__F7 PD-L1 upregulation in response to DNA double-strand breaks STAT3 STAT1 ATR RAD51 BRCA2 IRF1 ATM PMC2743272__F1 Mechanisms underlying the pleiotropic effects of statins in stroke CDC42 BMP2 ARHA RAC1 PMC6388629__F6 IPA network map depicting the DR signaling changes in HBEpCs after 6 h of infection with IAV H1N1 TBK1 CASP2 TRADD CYCS TANK GAS2 ARHGDIB REN BCL2 MAP10 TNFSF10 TWEAK DIABLO FADD SPTAN1 PMC7006459__F1 Fyn activates divergent signaling cascades in effector lymphocytes FYN BCL10 LAT PTEN LCK PMC6388629__F5 Ingenuity Pathway Analysis (IPA) network map depicting the DR signaling changes in HBEpCs after 2 h of infection with IAV H1N1 TBK1 TNFRSF1B CASP2 TRADD LIMK1 TANK ARHGDIB BCL2 MAP10 CRADD TNFSF10 TWEAK DIABLO SPTAN1 PMC6962108__F1 Mechano-sensing by LSECs drives fibrotic processes PIEZO1 HES1 YAP1 PMC2588608__F2 Pathway Annotation and Summary Hit Table ACAN DDT HP PMC12229552__F9 Schematic diagram illustrating the mechanism by which DDX1 lysine methylation mediates MATR3 alternative splicing to regulate IVDD NPS DDX1 EZH2 ME1 PMC4731263__F3 Mapping Proteome-Wide Interactions of Reactive Chemicals Using Chemoproteomic Platforms BAT5 PMC10486522__F1 Leptin and a schematic representation of leptin-induced signaling pathways STAT3 CAMKK2 SOCS3 MTOR IRS1 PMC10486522__F2 Adiponectin and a schematic representation of adiponectin-induced signaling pathways STAT3 APPL1 SOCS3 MTOR APPL2 SIRT1 IRS1 PMC3327653__F1 Recruiting a New Substrate for Triacylglycerol Synthesis in Plants: The Monoacylglycerol Acyltransferase Pathway LPA GPAT4 PC PMC6329310__F2 Role Of Atm In Ebv Life Cycle Regulation (A) The central role of ATM in the replication compartment of EBV BMI1 RAD52 RAD51 SP1 ATM MYC PMC6273696__F29 PI3K/Akt signaling pathway was regulated by vancomycin in HK-2 cells RHEB TSC2 BAD TSC1 HEL-S-28 PTEN CDC37 MDM2 GRB2 CCND1 CTNNB1 EIF4E PMC8198784__F3 Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis CIC AHR VCAM1 PMC6273696__F27 G2/M DNA damage check point signaling pathway was regulated by vancomycin in HK-2 cells AURKA PPM1D ATR MYT1 TRIP12 MDM4 HIPK2 C13orf34 WEE1 CHEK1 ATM RPRM MDM2 PMC6273696__F28 Apoptosis signaling pathway was regulated by vancomycin in HK-2 cells HTRA2 BAX BIRC6 FAS CAD MCL1 ROCK1 CYCS GAS2 TNF APAF1 DIABLO PMC8198784__F1 Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis TDO2 HEL-S-90n IDO1 KMO IDO2 PMC6484083__F2 The inferred and enriched PPI network from 43 genes that sensitize yeast to Mn when deleted POLL LIPE PMC8198784__F5 Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis STAT3 MTOR PMC6580320__F1 unctions and subsequent pathways of eukaryotic initiation factor 5A2 in human digestive system neoplasms ACSS2 FASN RHO EIF5A2 PMC3628365__F9 Speculative model of TERRA, hnRNP A1, and hTR/DNA-PKcs interactions at telomeres SMG1 PMC8939789__F7 Integrated model of potential mechanisms of HIV transcription and latency modulation by Beta-catenin CTNNB1 PMC8475157__F1 Abnormalities in the signaling pathway that exacerbate type I IFN responses STAT1 STAT2 IRF9 IRF1 STAT4 IRF7 IRF8 JAK1 TYK2 PMC11204236__F11 Proposed model illustrating the network of molecular mechanisms governed by miR-1 during early differentiation of the cardiac sinoatrial region NCOR1 CALM1 TBX5 GATA4 MED1 MEF2C PMC6525084__F3 RNA-seq identifies synergistic (GxE) genes, which are enriched in NF-kB signaling pathway TBP TRAF2 LCK PMC9662161__F5 Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells CDH2 RBM10 TNF CCND1 PMC10977403__F2 Dependence receptors have two properties: when the ligand is present, binding to the ligand promotes cell survival, migration or differentiation JUN FAS HEL-S-69p MTOR PMC5383785__F5 Depiction of RAS-ERK signaling pathway and primary and secondary connections to substrates identified by time-resolved phosphoproteome profiling MCAT STAT3 EGF TRIOBP JUND BAD GIGYF2 NUP214 RAF1 TP53BP2 SOS1 PXN ETV3 EGFR FOXP4 CNOT4 GIGYF1 CNKSR1 CNOT2 RHO FLNA LMO7 TPR ERF GRB10 TEAD3 HSF1 AHNAK RPTOR RPS6 NUP107 TCF12 TRIO FLNB NUP188 YAP1 IRS1 TP53BP1 RANBP2 NCOR2 PAK1 NUP153 TAF6 ERBB2 FOXK2 MAP2K2 TBC1D4 PMC4741654__F1 The complex metabolic network gearing the G1/S transition in leukemic stem cells: Hints to a rational use of antineoplastic agents FH DHFR CHDH PMC2395337__F1 5-Fuorouracil drug pathway demonstrating the interaction of multiple gene products FDXR FH RRM1 RRM2 DHFR DPYD DUT TYMS NME2 TK1 NFKB1 DPYS UNG GGH UMPS FPGS PMC5039188__F1 TLR signaling overview TBK1 TLR9 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC7039202__F1 Modular composition of the SGOCP MTHFD2 DHFR SFXN1 HEL-S-51e MTHFD1 HEL-S-68p PHGDH SHMT1 MTHFD1L PSAT1 HEL-S-61p MTR PSPH PMC7039202__F2 Sources of one-carbon units GLDC MTHFD2 AFMID AOC2 HEL-S-51e FTCD ADH5 UROC1 MTHFD1 TDO2 HAL SHMT1 MTHFD1L NAT1 PMC7039202__F3 Products of the SGOCP MTHFD2 SMS DHFR ARG1 HEL-S-51e AMD1 NNMT HEL-S-182mP SRM PEMT SHMT1 MTHFD1L SPTLC1 MAT1A PMC8753976__F3 Signal transduction mechanism of exosomes in diabetic complications (Review) ETS2 IGF1 SMAD2 PMC7039202__F4 Regulation of the SGOCP TSC2 TSC1 ATF4 EIF2A KDM4C PMC8753976__F4 Signal transduction mechanism of exosomes in diabetic complications (Review) TLR4 NUMB PMC9103730__F1 Abiotic Stresses in Plants and Their Markers: A Practice View of Plant Stress Responses and Programmed Cell Death Mechanisms ERF CD2 PMC4005613__F1 Molecular Pathways: Co-Expression of Immune Checkpoint Molecules: Signaling Pathways and Implications for Cancer Immunotherapy ZAP70 CD48 APC CD160 BTLA CTLA4 MTOR LAG3 LCK PMC8200641__F2 Endoplasmic Reticulum Stress, a Target for Drug Design and Drug Resistance in Parasitosis ATF4 EIF2A XBP1 PMC9661468__F4 Stress during mitosis activates apoptosis and inflammation CGAS IRF3 MDM2 PMC8301761__F1 Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer CXCR1 HGF KDR IL8RB PMC7051019__F2 a) Signaling pathways and transcription regulation of adipogenesis IGF1 EBP SIRT2 INS SIRT1 PMC8301761__F2 Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer RHEB TSC2 TSC1 INPP4B PI3 PTEN PMC8301761__F4 Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer TNKS APC GSK3B LRP5 LRP6 CTNNB1 PMC7802449__F4 Targeting TSH and IGF-1 Receptors to Treat Thyroid Eye Disease ECD TSHR IGF1R PMC8249129__F8 Therapeutic Targets and Mechanism of Xingpi Jieyu Decoction in Depression: A Network Pharmacology Study GSK3B BCL2 HEL-S-11 MTOR SRC MYC PMC6378304__F5 Strategies to overcome NK resistance in solid tumors CXCR3 TIGIT EGFR CXCL1 MICA CCL5 IL8RB MICB CXCL10 CXCL8 PMC5081350__F1 Wnt/Beta-catenin signaling pathway BCL9 TNKS APC GSK3B LRP5 LRP6 PMC6639976__F5 CXCL13 in prostate cancer CXCL13 CXCR5 PTEN PMC11206888__F7 Diagram of PI3K–AKT signaling pathway BAD GAL RBL2 PTEN CD19 MTOR MYC IRS1 EIF4E TSC2 CD37 MEI1 MDM2 PMC5081350__F3 Wnt/Beta-catenin signaling therapeutic targets BCL9 TNKS GSK3B PMC2737270__F1 Autophagy pathway and machinery.A ALG5 ATG10 ALG12 ATG3 ATG12 PMC5325695__F1 Emerging roles of p53 and other tumour-suppressor genes in immune regulation IFNE BAX TBK1 FAS STAT2 IRF9 TLR9 IRAK1 IRF3 IRF7 TRAF6 IRAK4 STAT1 TLR3 IFNAR2 IFNAR1 TLR8 TLR7 ISG15 PMC8200641__F4 Endoplasmic Reticulum Stress, a Target for Drug Design and Drug Resistance in Parasitosis SEC63 EIF2A PMC8219969__F1 Promising Future of Ferroptosis in Tumor Therapy SLC3A2 TFRC GPX4 SLC7A11 ATF4 PMC1817784__F2 Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders RHEB EEF2K TSC2 TSC1 MTOR PMC6861747__F17 Antidepressant-like effects and mechanisms of GXDSF via mediation of the CaMKII-CREB-BDNF signalling pathway in chronic unpredictable mild stress (CUMS)-induced depressive rats NGF FST BDNF PMC5462960__F7 Location of BHP biosynthetic genes and gene clusters in the genomes of SD1, SD3, and SD4 Acidobacteria and a number of selected environmental genomes as determined by BLAST protein searches HMGCR MVD SHE MVK PMC9381850__F7 Comprehensive Analysis of Interferon Regulatory Factor Expression: Correlation with Immune Cell Infiltration and Patient Prognosis in Endometrial Carcinoma DAP MIP HEL-S-70p EDAR FADD PMC9300693__F7 Proposed mechanism by which thiostrepton modulates ferroptosis via the STAT3/GPX4 signalling pathway STAT3 GPX4 SLC7A11 HEL-75 PMC2935989__F3 GRK2 interactome involved in the modulation of cell cycle progression ADRBK1 CDC2 FOXM1 CDK2 SMO PIN1 PMC7588972__F1 Pivotal role of Mediator complex in the ABA signaling pathway CDK8 MED18 MED25 PMC2935989__F2 GRK2 interactome involved in cell migration RGS2 CCR5 SMAD2 APC IRS1 ADRBK1 KCNJ3 RALA PAWR TLR3 TLR4 RGS4 CCR4 TLR7 MDM2 GRB2 SRC CXCR4 PMC3102695__F5 Ciliary Neurotrophic Factor Induces Genes Associated with Inflammation and Gliosis in the Retina: A Gene Profiling Study of Flow-Sorted, Müller Cells STAT3 KLF2 CEBPA GFAP ARHGEF11 UBTF LETMD1 PMC7588972__F2 Simplified network of TFs and Mediator complex in regulating the abiotic stress responses CDK8 MED14 MED16 MED25 PMC8973533__F5 Carbohydrate regulation response to cold during rhizome bud dormancy release in Polygonatum kingianum GAL ME2 STS PMC11024860__F9 Working Model: HDAC6 maintains primordial follicle dormancy TF TSC2 NGF BDNF HDAC6 PMC3791614__F1 The interactions between the control of the cell cycle and the expression of specific ligands for activating NK receptors in various pathologies ATR PCNA RAE1 CDK2 CDK4 PMC9105874__F1 Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors RIPK3 TRPM7 GSDMD CASP8 NLRP3 C2 MLKL IL18 RIPK1 IL1B FADD PMC9105874__F2 Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors PLCG1 GSDMD TRPM2 TRPV2 IL18 IL1B PMC6874533__F9 Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation, invasion, and self-renewal of hepatocellular carcinoma stem cells NKD1 HOXA11 CCND1 CTNNB1 PMC3249073__F1 PtdEtn synthesis pathways in Plasmodium and yeast MME PSD PMC2666844__F3 In the absence of Wnt stimulation, the APC (adenomatous polyposis coli) forms a trimeric complex, known as the “destruction complex,” with glycogen synthase kinase-3B (GSK) and Axin COX2 APC AXIN1 AXIN2 CTNNB1 PMC2666844__F5 Simplified schematic of hepatocyte growth factor (HGF)/MET signaling pathway HGF GRB2 PMC7693344__F1 Metabolic enzymes associated with glycolysis and the pentose phosphate pathway, depicted here, serve as critical regulators of inflammatory responses in myeloid and lymphoid cells MTOR HEL-S-30 MYC PMC2666844__F6 Simplified schematic diagram of transforming growth factor-alpha/epidermal growth factor receptor signaling pathway (TGFA/EGFR) TGFA EGFR GRB2 PMC8323674__F1 Research trends, hot spots and prospects for necroptosis in the field of neuroscience TLR3 MLKL TLR4 CRIP3 TNF PMC12245917__F1 Molecular signal pathways related to H CDC2 CGAS MMP10 RELB APC TAB3 LRP5 LRP6 IRF3 MMP9 TRAF6 CTNNB1 LATS1 CDX2 MMP3 TIFA TRAF2 PMC12245917__F2 Crosstalk among H YAP1 CTNNB1 PMC5802806__F5 Proposed mechanism C7 SRR PMC6343143__F2 Proposed model of estrogen-induced ROS generation increase in thyrocyte TPO SSB NOX4 PMC1782589__F2 Signalling cascades of the LPS pathway and reported sites of IL-10 intervention RAF1 MAPKAPK2 GSK3B CD14 LYN PMC11635231__F2 Importance of FXR in the enterohepatic circulation of BAs FGF8A ABCG8 NR2A1 ABCG5 CYP8B1 BAAT CYP7A1 FGFR4 GCA CYP7B1 CYP27A1 PMC11635231__F3 FXR in four lung diseases STAT3 EGF SNAI2 SNAI1 EGFR NQO1 GCLC IL18 IL6ST ARL11 TNF PMC7082402__F1 Red blood cell—inflammation vicious circle in sickle cell disease NLRP3 TLR4 IL1B PMC9552847__F7 PTEN loss promotes Warburg effect and prostate cancer cell growth by inducing FBP1 degradation FBP1 PTEN SKP2 PMC3248767__F2 Bevacizumab Treatment for Advanced Breast Cancer EGF HGF TGFA PMC11577950__F7 Metabolic pathway diagram of lysosome and autophagy pathways of DEGs after knockdown of HlDnmt1 and HlDnmt in Haemaphysalis longicornis ACP2 GAA GUSB GLA HGSNAT CLN3 LIPA IDUA NAGA GM2A HEXA LITAF GNS SGSH GALNS ABCA2 AGA ABCB9 ACP5 PMC2888475__F1 Cellular apoptosis pathways and intervention by both cellular anti-apoptotic proteins and viral proteins encoded by oncolytic Ad, HSV and VV CASP9 BCL2 FADD PMC9380140__F7 Upregulation of RCAN1.4 by HIF1A alleviates OGD‐induced inflammatory response in astrocytes COX2 IL18 HIF1A IL6 PMC8213017__F1 Modulation of Ferroptosis and Its Role in Central Nervous System Diseases TF SLC3A2 IPP GPX4 LPCAT3 FACL4 SLC7A11 ADA PMC3401974__F2 Mammalian target of rapamycin (mTOR) pathway regulates T-cell activation, differentiation and migration APC CCR7 MTOR PMC11726960__F2 Key characteristics of models used to recreate cardiac systems in vitro and relevant signaling pathways SHF IGF1 BMP4 APC LRP5 LRP6 CTNNB1 PMC3055312__F1 Signaling pathways regulating GSK3 and functions of GSK3 related to mood regulation TF LRP5 LRP6 BDNF DISC1 CTNNB1 PMC6713350__F5 Bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells HEL-S-31 TNC TSHB CXCL12 MLKL DOCK6 MYLK VEGFB RARA SOST CD300A NID2 CDK6 CD74 F2R BMP4 ADAM15 PLCB3 SPON2 SBNO2 SNAI2 LBH SGCB CDK17 AXL STK40 CD248 NRP2 GPC3 ARPC1B STS TLR3 AGER MGP PMC10484938__F7 Metabolic remodeling in the brain and liver following STF ASS1 ASL FOLH1 GPT2 RIMKLA RIMKLB HEL-S-61p MTR CIT PMC6182269__F1 Cell intrinsic dysregulation of innate immune signaling in MDS HSCs TIRAP CD14 TIFAB IRAK1 IRAK2 IL6 TRAF6 IRAK4 MYD88 IL1R1 NLRP3 IL16 RELA IL18 IL1B PMC8074054__F1 Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together IGF1 IL16 TNF PMC6460856__F3 MyD88 played a critical role in alveolar macrophage-mediated inflammatory response to CNTs TRAF6 IL1B MYD88 PMC4570544__F1 The Clp proteases and chaperones in Plasmodium and the Plasmodium translocon of exported proteins CSA2 CLPP CIPC PMC5876639__F2 Cellular senescence pathway activated by NPM-ALK STAT3 CDK6 ALK CDK4 PMC11890630__F8 Progressive accumulation of transcriptional alterations during the progression of T2D reduces adipocyte thermogenic capacity MAX PLN BAX PER2 PTEN C1orf51 RORB LRPPRC PACS1 ASF1A RYR3 NLRP3 CASQ2 CIDEA RELA PDE3A EDNRA RYR1 PPARGC1A HDAC11 BAK1 SIRT1 DIABLO NPRC PMC5187684__F1 A schematic of metabolic intermediate labeling from 13C glutamine HEL-S-26 NNT PMC8240065__F4 Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles SNAP23 CD48 CR2 IRAK1 CXCL2 CCL5 TRAF6 CCL2 CR1 IRAK4 MYD88 TLR4 CCL7 LYN IL1B PMC6460856__F2 Mechanisms by which carbon-based nanoparticles induce cytotoxicity of macrophages NLRP3 IL16 PMC9710325__F2 Perspectives on Challenges in Cannabis Drug Delivery Systems: Where Are We? BAD COX2 ATF4 ARHA SRC TRIB3 PMC8340019__F4 Jasmonates, Calcium, and Glutathione in Plants to Combat Abiotic Stresses Through Precise Signaling Cascade MAPK4 ERF MYC PMC10977574__F8 Compound-key target-core pathway NRK OXTR CTSH PGR AKT3 JAK3 BRAF NR1C2 CTSC MYLK BTK REN ALK FLT4 DPP4 MMP2 ATM ACHE NGFR TRPV1 SNCA VEGFA FURIN TNF CCKAR NR1C1 CDK5 CHRM2 HEL-S-130P c-fgr PDGFRA EDNRA PBR FGFR3 PIGS CXCR4 RET LCK PMC2868837__F3 Major gene products affected by virulent infection VEGFC JUN EGR1 EGFR IL1RL1 IL1A PTGS2 VEGFA EGR2 FOS IL1B PMC7281398__F5 Summary of Gene Ontology Analysis and Pathway analysis on genes that are associated with ex vivo VP16 response, ranked according to adjusted p-values RMI2 PCNA HMMR ZWINT GMNN CKAP2 FANCG BYSL MTFR2 UNG HLTF CENPA POLE PMC7409324__F2 NFkB-induced expression of MHC-I RELA RELB TRAF6 TRAF2 PMC10977574__F9 Core-compound-core key target-core pathway PPARG PIK3CA EGFR PIK3R1 TERT MTOR MAPK3 ALK F2 MMP2 MMP3 KDR MDM2 SRC PTPN11 PTGS2 MMP9 IL6 TNF HDAC1 HMGCR NFKBIA CDK2 BCL2 JAK1 LCK PMC6357155__F2 The life cycle of SARS-CoV and MERS-CoV in host cells HEL-S-69p DPP4 ACE2 PMC7409324__F3 Interferon (IFN)-induced expression of MHC-I IFNG STAT3 IFNGR2 IFNGR1 STAT2 IFNAR2 IFNAR1 IRF1 JAK1 TYK2 PMC7409324__F4 Therapeutic interference to boost MHC-I antigen presentation of tumors STAT3 STAT2 ITCH EGFR IRF9 PTPN1 PTPN11 IRF1 IRF3 PIN1 RNF2 IFNG STAT1 SMURF1 DUX4 N4BP1 RELA JAK1 CYLD PMC8517994__F2 MiRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer FAS ATG9B EIF2A XBP1 PMC10938947__F2 Introduction of pathways related to bone regeneration, like WNT signaling pathway APC LRP5 MSC LRP6 PMC7555571__F1 AHR signaling pathway AIP AHR AHRR CYP1B1 SRC PMC8651533__F2 Proline metabolism and redox; maintaining a balance in health and disease ALDH18A1 PRODH PYCR2 PMC9199231__F1 Interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms ACTL6A AJUBA RHO NLK VGLL4 PMC10938947__F3 Introduction of pathways related to bone regeneration, like Hedgehog signaling pathway, Notch signaling pathway and FGF signaling pathway FRS2 DLL4 MSC JAG2 IHH SMO GRB2 DLL3 PMC10938947__F4 Introduction of pathways related to bone regeneration, like BMP/TGFBsignaling pathway SMAD1 MAP3K7IP1 DKFZp781O1323 SMAD2 SMAD6 MSC SMAD4 PMC5816931__F2 Recognition of Mycobacterium tuberculosis (Mtb) by Dectin-1 SYK BCL10 APC TNF CARD9 PMC7291661__F2 Proinflammatory cytokines regulating keratinocytes or stem cells TRAF4 STAT3 CTNNB1 PMC10977574__F7 Core pathway of AP intervened by SHG (PI3K-Akt signaling pathway) BAD RXRA MDM2 GRB2 RAC1 IRS1 PMC4377297__F1 The role of trophoblastic microRNAs in placental viral infection AGO2 DROSHA PMC7465511__F2 MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment TET2 BRD4 ZRSR2 GATA1 BAP1 MTOR ME3 MPL RUNX1 tal-1 EPOR U2AF1 MEIS1 BCL2 TPO HEL-S-26 JARID2 SOX4 PMC8277214__F1 Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study CERS3 CERS5 CERS1 tmp_locus_29 CERS2 KDSR CERS6 PMC6742404__F1 Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison MBP MOBP KLF9 NR1A2 LAT2 THRA PMC5696170__F7 Measurements of heterotypic associations between cluster of differentiation CD74 and CD44 in human breast cancer-derived cells CD44 CD74 RELA MIF PMC7528551__F2 Phosphatidylcholines constitute a major metabolic signature of VAT versus SAT AGPS CHPT1 PEMT CEPT1 CHKA PMC6949682__F5 Canonical pathway; (b) heat map of the genes related to the colitis signaling pathway in colonic epithelial cells obtained from wild-type (WT) and Slc5a8-null (KO) mice fed the fiber-free diet (FF-diet) MAX VNN1 STXBP1 CD3D DPPA3 GNRH1 PTPN5 F2RL2 TBX21 INHA C9 TDG VIP NOS2 C1orf51 NR1C1 CMA1 HSD3B1 CYP2C9 GPR173 KISS1R SLC13A1 KRT13 HLA-A CD3E DEFA3 PMC3636710__F9 LBP/CD14-independent activation of host cells by E·albumin TLR4 CD14 LBP PMC7547598__F6 Transcriptome analysis reveals potential immune function-related regulatory genes/pathways of female Lubo goat submandibular glands at different developmental stages IL20RB GRAP2 PRKD2 TNC SYK LRRC4 HEL-S-81p SHD LAT MYBL2 THBS2 HLA-DOA DNTT ELL CD5 RAG2 PTPRC TAP1 ORC1L CDKN2D MYC TRIM21 CSF3R CDKN2C UNG RAG1 CAMK4 TAP2 POLE MARCO RASAL3 AMPH CD2 LIMK1 HEL70 VAV1 ITGB3 TUBB SPN IFNAR2 FCER1G CCR4 NFATC3 CXCR4 PMC7547598__F8 Transcriptome analysis reveals potential immune function-related regulatory genes/pathways of female Lubo goat submandibular glands at different developmental stages ZAP70 CD48 LAT IL4 CTLA4 ICOS CBL FYN BCL10 ITK GRB2 LCK CDK4 PMC10816220__F1 Transforming growth factor B (TGFB) and bone morphogenetic proteins (BMP) signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 ARHA MTOR SMURF2 PMC6769118__F9 Anti-autophagic and anti-apoptotic pathway activated in human DCs by P TLR1 ULK1 PMC7090203__F3 Physical activity alters circulating monocyte features and obese adipose tissue macrophage distinction KLF4 IFNG STAT1 CCR5 TLR4 CCR2 CD14 IRF3 IRF4 CCL2 PMC7090203__F2 LPS transferring pathway and modulation of TLR4 signaling cascade TIRAP TLR4 CD14 IRF3 TRAF3 TRAF6 LBP MYD88 PMC6704489__F3 Gene category of the NFKB signaling pathway SYK LTA LTBR TRADD TIRAP LAT TRIM2 TRAF3 TRAF6 DAO TRIM21 NGF PLCG1 BTK BCR ATM MIP IL1B CD14 BLNK LTB CNTF LYN LBP TRAF2 BIK LCK PMC3671299__F2 Schematic diagram of AB accumulation mechanism ACHE BACE1 SREBF2 MYOCD EIF2A PMC5424863__F2 Pathway hyperactivation defined by alterations of the PI3K/AKT/mTOR pathway RHEB TSC2 TSC1 PTEN PMC3887202__F1 De novo synthesis of steroids, oxysterols, and bile acids from cholesterol STAR CYP17A1 CYP11B2 CYP8B1 CYP11A1 PBR CYP7B1 CYP27A1 PMC6713396__F4 Transcriptional blood signatures for active and amphotericin B treated visceral leishmaniasis in India CYP1A2 BAX OGT FAS AHRR NR0B2 TNF NCOA7 NR2F1 NEDD8 NF1 NR3A2 AHR PMC9274491__F8 RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes malignant phenotypes of pancreatic ductal adenocarcinoma TIAM1 YAP1 PMC3903278__F8 Cofilin regulating actin dynamics and initiating HSV-1 entry LIMK1 EGFR ROCK1 RHO PMC8067275__F1 MicroRNAs that regulate the core components of Hippo signaling pathway LATS1 LATS2 NF2 AREG VGLL4 PMC5115734__F1 Evolution of the Tetrapyrrole Biosynthetic Pathway in Secondary Algae: Conservation, Redundancy and Replacement CPOX FECH UROD UROS PMC3576027__F2 Activity-dependent neuronal signalling and autism spectrum disorder UBE3A TSC2 TSC1 ARC MTOR BDNF PMC3576027__F3 Activity-dependent neuronal signalling and autism spectrum disorder UBE3A CARF NPAS4 ARC BDNF PMC3561559__F9 Schematic model of autoregulation of BMI1 BMI1 APC CTNNB1 PMC2684140__F9 Schematic representation of the S CDC2 MOB2 ACE2 PMC8811422__F19 Chinese Herbal Formula Ruyan Neixiao Cream Inhibits Angiogenesis of Precancerous Breast Lesions via Regulation of Ras/Raf/MEK/ERK Signaling Pathway HRAS TIMP3 RECK PMC4238427__F4 Ingenuity pathway analysis of top differentially affected pathways from the microarray data KLF2 GAPVD1 TRIM2 GMFB PMC5925761__F1 One-carbon metabolism (1-CM) and pentose phosphate pathway (PPP) at the cross-road between anabolism and redox balance MTHFD2 PHGDH ATF4 TIGAR MYC KRAS PSPH PMC6780043__F4 Effects of nanomaterials (NMs) on Ca2+ channels located on the cell membrane and Ca2+ stores and subsequent dysfunction of ion homeostasis STIM1 MTOR PMC6894260__F1 Wnt/Beta-catenin signaling pathway RNF43 DKK1 APC LRP5 ZNRF3 LRP6 CTNNB1 PMC8160634__F4 Potential Role for HUWE1 in Modulating Cisplatin Sensitivity MEI1 ATM HDAC2 HUWE1 PMC10610204__F4 Activation of DNA damage-induced checkpoint signaling pathway in ATM-deficient cells and mechanism of ATR inhibitor and ATM defect-induced synthesis and lethality (by Figdraw) ATR ATRIP ATM PMC10610204__F5 WEE1 and TP53 synthetic lethal interaction mechanism (by Figdraw) CDC2 ATR WEE1 CDK2 ATM SSB PMC7148120__F3 Microglial activation on metabolism IFNG CX3CR1 CX3CL1 PMC5735682__F9 Hypothetical illustration for the role of CWP APC GSK3B CTNNB1 PMC8160634__F2 Potential Role for HUWE1 in Modulating Cisplatin Sensitivity TOPBP1 ATR CDC6 HUWE1 PMC5821468__F5 Severe congenital neutropenias GATA2 RAB27A LYST GFI1 JAGN1 VPS13B HAX1 G6PC3 SBDS AK2 WAS CXCR4 AP3B1 PMC8712645__F1 Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy TBK1 RAD50 CGAS MAVS MRE11A BRCA1 IFI16 IRF3 CARD9 PMC8712645__F4 Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy CGAS CTLA4 PMC5450843__F10 A model for transcriptional regulation of RGC differentiation DLX1 ISL1 DLX2 VSX2 PMC4097318__F1A Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis PNPLA3 CCL2 TNF PMC3079800__F1 Parenteral Nutrition Impairs Lymphotoxin B Receptor Signaling via NF- KB IL10 CCL19 LTBR CCL25 MADCAM1 IL16 RELB CCL20 PMC9105027__F1 Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis PRG4 HBEGF TGFA EGFR SMAD2 SMAD4 PMC9105027__F2 Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis PRG4 ADAMTS4 APC LRP5 ADAMTS5 MMP3 LRP6 MMP9 CTNNB1 PMC5655361__F2 Signaling networks in aging TSC2 TSC1 SGK1 KRI1 PMC3072066__F5 Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state NKX2-2 SHH OLIG2 PAX6 FGF2 PMC3294166__F8 KEGG pathway mapping overlay for acidic pHe upregulated genes pertinent to OXPHOS SDHD CYB ND6 COX3 SI ND3 ND2 PMC2254485__F5 Tumour growth and metastasis: Role of NPP2-catalyzed reactions LPA WNT1 CTNNB1 PMC9612825__F1 Metabolic network RPE GAA GOT2 HEL-S-162eP MAL PIR HEL-S-32 CS MDH2 ME1 GPT CIT PMC8308226__F1 MiR-155 in Nutrition: Modulating Cancer-Associated Inflammation SOCS1 STAT3 SMAD4 IL6 ARHA JAK1 VHL PMC5354660__F5 Cycling hypoxia affects cell invasion and proliferation through regulation of claudins CDK6 DHFR SUV39H1 CDK4 PMC7796621__F7 Schematic model of the anti-inflammatory effects of hMuSCs on DSS-induced IBD AHR TNF PMC7555602__F3 Impact of redox imbalance on canonical pathway of miRNAs biogenesis RAN GSK3B DROSHA PMC3901115__F2 Autophagy pathway: Molecular features ATG12 AMBRA1 MTOR PMC2410042__F2 Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival BRD4 TGFB1 CSF1 TXNIP TGFBR3 EZH2 PTEN TGFBR1 SAP30 SIPA1 TFPI NDN RRP1B PI16 CSF1R PMC3784161__F1 AKT-mammalian target of rapapmycin (mTOR) signalling pathway RHEB TSC2 TSC1 FOXO1 GSK3B PTEN SRC IRS1 PMC3784161__F2 AKT controls T-cell differentiation RHEB RICTOR APC MTOR PMC4735774__F9 Schematic working model for presumed mechanisms underlying the effects of Mus81 knockdown on hepatocellular carcinoma (HCC) cells in response to chemotherapeutic drugs CDK2 PMC9139752__F1 Can Schlafen 11 Help to Stratify Ovarian Cancer Patients Treated with DNA-Damaging Agents? ATR SLFN11 EZH2 PMC7584116__F2 T cell metabolism by SOCE and Ca2+ signaling PANX1 STIM2 ORAI1 HK2 STIM1 SLC2A3 HIF1A IRF4 MYC PGC NR1C1 CAMKK2 ACADVL CAMK4 HEL-S-87p PMC6461560__F4 Phosphosites identified in proteins of the RAS-RAF-MAPK and PI3K-AKT-mTOR signaling pathway in H3255 (left panel) and H1975 (right panel) RPTOR EGF EIF4G1 RICTOR RPS6KB1 GRB2 MTOR EIF4E PMC7584116__F1 Ca2+ regulates metabolic pathways at different stages of the T cell life cycle PANX1 CD80 CAMKK2 APC PMC9206313__F2 RCAN1-mediated calcineurin inhibition as a target for cancer therapy IGF1 MAK GC IGF1R IL11 IL8RB VEGFA RCAN1 PROKR1 CXCL8 NFE2L3 PMC9095921__F1 Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke CCL3 GIP RHO PMC1526532__F1 Genomic Analysis of the Opi− Phenotype MME PC PSD2 PMC8423581__F3 Exosome: Function and Application in Inflammatory Bone Diseases TRAF5 PTEN SRC TRAF6 TNF TRAF2 PMC8423581__F4 Exosome: Function and Application in Inflammatory Bone Diseases LRP4 SOST APC LRP5 LRP6 ATF4 RUNX2 PMC10750275__F1 YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer LATS1 LATS2 RHO NF2 PMC6590390__F1 Wnt, Beta-catenin. and PCP signaling JUN APC ARHA RAC1 CTNNB1 PMC4057899__F8 Schematic diagram OXT EGF OXTR EGFR IL1B PMC5143481__F2 TLR4 signaling mechanisms TIRAP TLR4 CD14 IL1B MYD88 PMC8423581__F2 Exosome: Function and Application in Inflammatory Bone Diseases CSA2 RELA RELB TRAF6 IRAK4 MYD88 PMC5903700__F6 Schematic diagram summarising the biological processes underlying the association of the 35‐gene expression signature with PTEN/AKT signalling pathways TPT1 HEL-S-273 PTEN MTOR ACTG2 PMC9039621__F1 Complement-Mediated Neutralisation Identified in Ebola Virus Disease Survivor Plasma: Implications for Protection and Pathogenesis C6 TH FCN1 CS C4B_2 PMC9189314__F2 Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis GSDMD TXNIP IL1B PMC10137108__F1 Contribution of various long non-coding RNAs and microRNAs in osteogenic pathways MAP3K7IP1 SMURF1 APC LRP5 LRP6 SMURF2 DLX5 RUNX2 CTNNB1 PMC10137108__F2 Bone formation by miRNAs SOST RUNX2 PMC11602477__F1 Wnt/Beta-catenin pathway in CSCs APC RHO CTNNB1 PMC10137108__F3 Long non-coding RNA that regulates osteosarcoma invasion and metastasis FGFR3 PMC11602477__F2 Notch signaling pathway in CSCs (By Figdraw) NOTCH2 NOTCH3 NOTCH1 PMC11602477__F3 Hedgehog signaling pathway in CSCs SUFU PTCH1 SHH SMO PMC6345911__F7 Postulated mechanism for ceramide dependent regulation of G-CSF signaling in BMCs STAT3 CERS2 CXCL2 LYN IL8RB PMC10750275__F7 YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer HMGB1 SKIL PTEN ATG5 PMC10151765__F2 Generation, activation, and polarization of monocyte-derived macrophages in human malignancies FAS FYN PARP1 FADD PMC6330281__F2 Wnt signaling cascades SOST APC GSK3B LRP5 LRP6 CTNNB1 PMC4248054__F1 Mechanism of oestrogen action HBEGF EGFR SRC PMC7015151__F1 Outline of T-cell development and T-cell gene regulatory network MYB LMO2 TCF12 IKZF1 GFI1B LYL1 HHEX KIT RAG2 ERG BCL11A SPI1 GFI1 MEF2C GATA3 RORC RUNX1 HOXA9 MEIS1 RAG1 ATL1 LEF1 HES1 PMC3062054__F4 Roles for Growth Factors in Cancer Progression BCR EGFR KIT PMC3062054__F2 Roles for Growth Factors in Cancer Progression ERF BAD SMAD2 SMAD6 SMAD4 PTEN MYC FOS PMC8075259__F2 Anaplasmataceae: Dichotomous Autophagic Interplay for Infection RHEB TSC2 TSC1 GSK3B TFEB ATG14 PTEN SQSTM1 ETF1 ATG5 PMC8396570__F1 Putative Role of Vitamin D for COVID-19 Vaccination SYK TBK1 TLR9 IRF3 IRF7 TRAF6 CCL2 IRAK4 NLRP3 TLR3 TLR4 CCL7 TLR7 PMC8134850__F7 Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NFKB and TGFB1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling TIMP1 KEAP1 SMAD2 NQO1 SMAD4 MMP2 MMP9 TNF PMC3556981__F5 Analysis of Central Metabolic Pathway Gene Expression with Compartmentalization Information.Heat maps in boxes indicate the expression of individual genes, and the chart plots indicate the aggregate expression levels of the pathway genes FH CS PMC9254496__F1 Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways IPP DMD MVK PMC3767923__F6 Schematic of DNA damage response to double strand breaks XRCC5 PNKP NHEJ1 PRKDC ATM PMC8398289__F3 Elucidation of Melanogenesis-Associated Signaling Pathways Regulated by Argan Press Cake in B16 Melanoma Cells RAB27A ATP2B1 MAP3K12 DCT CTNNB1 PMC3177306__F2 The canonical vertebrate Wnt signaling pathway HIPK2 DKK1 APC LRP5 LRP6 CTNNB1 PMC1774601__F2 Death receptor mediated (extrinsic) pathway of apoptosis FAS TRADD FADD PMC6036444__F1 Schematic of one-carbon metabolism MTHFD2 MTHFD1 DHFR AMT MTHFD1L SHMT1 HEL-S-51e PMC2970711__F7 Scheme of cross-talk interactions between TIM-3, Gal-9 and TLR4 signaling networks CXCL12 TLR4 CXCL1 IL1B PMC9157498__F2 Noncanonical PD-1/PD-L1 Axis in Relation to the Efficacy of Anti-PD Therapy CD40 STAT1 CD80 EIF4E PMC7419046__F2 TGF‐B signaling regulates lncRNA expression and mechanisms of TGF‐B signaling control by lncRNAs SMAD2 SMAD4 TUG1 PMC5450629__F8 Tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas IGF1 IL4 IGF1R PMC4063317__F5 Receptors and cellular signaling pathways implicated in the antitumor effect of ANP STAT3 CORIN GSK3B CTNNB1 PMC4227274__F9 Cellular defense mechanisms induced by IPNV infection in CHSE-214 cells STAT1 BAD TLR3 PMC6245951__F7 Attenuating Effects of 1,2,3,4,6 Penta-O-Galloyl-Beta-D-Glucose on Pro-Inflammatory Responses of LPS/IFNGamma-activated BV-2 Microglial Cells through NFƙB and MAPK Signaling Pathways CDC42 TIRAP CD14 IRAK1 ARHA SHE TRAF6 IRAK4 DOCK2 MYD88 CRK TIAM1 TLR4 ITK GRB2 LBP FADD PMC11545288__F6 PPI network analysis of core targets screened from potential targets (A) and network diagram of the active component–key target pathway (B) of sugarcane vinegar polyphenols to mitigate oxidative stress STAT3 CGA RELA GSK3B NFE2L2 CDK2 PTGS2 MMP9 PMC11545288__F7 Mechanistic Insights into the Antioxidant Potential of Sugarcane Vinegar Polyphenols: A Combined Approach of DPPH-UPLC-MS, Network Pharmacology and Molecular Docking USP25 TH S100A7 FRY SP2 TRAF3 LCN2 CCL2 TNF S100A9 CCL20 PMC7568159__F2 MyD88 and IRAK-4-mediated signaling pathway TLR1 TLR3 TLR4 TLR9 TLR8 TLR5 TLR7 TLR10 IRAK4 MYD88 PMC3099592__F2 Activation of mast cells initiates a cascade of events resulting in Th2 polarization and both positive and negative feedback regulatory loops JAK3 PMC5342987__F1 BMP4 cellular signaling pathway including activators and inhibitors BAMBI SMURF1 SMURF2 PMC3073545__F2 Endocannabinoids in Liver Disease LPL TG FAS PMC4989048__F3 PhenomeExpress analysis TGFBI BUB1B SPARC FHL2 ZWINT BACH1 SOX9 ST6GALNAC2 PDGFC MAF COL8A2 CDKN3 CD163 S100A4 HLA-DQA2 TNFRSF12A SERPING1 TNFRSF4 FZD2 dik PLAUR ROR2 RUNX1T1 HAPLN1 ZDHHC4 ZNF329 LGALS9 FAP KIF1A SNRPN CLUH VCAN COL2A1 TNFRSF10D RAP2C MMS22L ATF3 CFDP1 NPEPL1 L3MBTL1 RUTBC3 FBLN5 SNCG PNMA2 MCM3 LAMB3 BLCAP LRP1B TRAF1 MYO1B COL9A2 TWEAK CCL20 DUSP10 COMP LGALS8 HMGA2 MAPK11 IGFBP6 HSD17B12 PLAT COL1A1 FZD1 TOP2A ITIH4 DBF4 LTBP2 CDC2 ETS2 IGF2 CD44 ACADL CEP55 GJA1 TYK2 TNFRSF11B SELP PMC11011352__F1 Regulating Protein–RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway LIN28B DGCR8 LIN28A TUT4 DROSHA PMC2912804__F7 Role of PGE2 in bridging TLR4 signaling and intestinal tumorigenesis COX2 TLR4 EGFR PMC6189293__F1 Complex interplay between O-GlcNAcylation and PI3K/AKT/mTOR signaling pathway controls numerous biological processes OGT TSC2 MTOR PMC6189293__F2 O-GlcNAcylation and PI3K/AKT/mTOR signaling pathway cross-dysregulation in human chronic diseases BAD HEL-S-133P FOXO1 GSK3B MMP2 MMP9 MTOR SMURF2 RUNX2 IRS1 PMC3583082__F3 This diagram summarizes the signaling pathway in thyroid carcinomas BRAF PTEN MTOR CTNNB1 PMC3632399__F5 RAS oncogene signaling JUN SP1 COX2 SP2 MMP2 MMP9 VEGFA FGF2 PMC4048454__F5 Metabolic pathway of vancomycin biosynthesis CIT PMC8969440__F7 Cordyceps militaris Modulates Intestinal Barrier Function and Gut Microbiota in a Pig Model TIRAP TLR4 TRAF6 MYD88 PMC9454096__F1 Evasion of interferon-mediated immune response by arteriviruses MAVS SP1 TLR3 STAT2 SP4 TANK SP2 IRF3 IRF7 ISG15 TRAF6 PMC4248746__F10 Model depicting the molecular mechanism involved in counterregulation of TLR-induced inflammatory signature by dectin-1 SYK PIAS1 IRAK1 CTNNB1 MYD88 PMC3457991__F3 Systematic Analysis of microRNA Targeting Impacted by Small Insertions and Deletions in Human Genome CASP9 EGF BAD GLS BRCA2 SMAD4 HEL-S-11 JAK1 PMC7757045__F4 LncRNA Regulates HCC Invasion and Progression by Modulating Tumor Immune Escape EGFR GADD45B LCK PMC8224460__F1 Resistance Responses of Potato Plants to Potato Virus Y Are Associated with an Increased Cellular Methionine Content and an Altered SAM:SAH Methylation Index CBL PMC12107760__F9 Changes in the main metabolic pathways of wheat root system in response to Act12 inoculation under drought stress PAH PHOSPHO1 PMC8933007__F4 Nicotinamide n-methyltransferase (NNMT) links nicotinamide adenine dinucleotide (NAD) and methionine metabolism during replicative senescence NNMT NMNAT1 NAMPT HEL-S-61p MTR PMC10960729__F6 Activation of cGAS–STING signaling pathway in autoimmune diseases, neurological diseases, and visceral inflammations ATM TREX1 DNASE2 C9orf72 PMC4066639__F5 Stress-signaling pathways in C CDC42 HEL-S-99n SP1 RAC1 HEL-75 PMC5445269__F3 Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans RHEB PINK1 SGK1 PMC8001543__F4 IL-7 effect on restoring 4-1BB signal transducer in HCV-specific CD8 T cells TGFB1 APC ELL TRAF1 PMC5528541__F9 A working model of Lhx2‐induced tumor progression SMAD2 SMAD4 PMC7118498__F2 TGFB 1 acts as a double-edged sword SMAD1 TGFB1 SMAD2 PMC6994220__F1 cis-carotene biosynthesis and regulation of PLB formation during skotomorphogenesis POR CR2 DET1 PMC7289600__F3 ERK and tested pathways RAP1GAP EGFR RAC1 PMC7118498__F1 TGFB 1 acts as a double-edged sword MAX TF MMP7 EGF SMAD1 HGF HMGA2 DKFZp781O1323 STAT2 ULK1 SMAD2 APC GSK3B SMAD4 HEL-S-28 MTOR IL6 TNF MYC GC ZEB2 IL1B PMC7326812__F5 Ingenuity pathway analysis (IPA) HCAR2 ANGEL2 NR1C1 ETS2 KLF9 EVI1 MAFB TNF TEF HNF1A PMC10244118__F8 Ly6D facilitates chemoresistance in laryngeal squamous cell carcinoma through miR-509/Beta-catenin signaling pathway LY6D ABCC1 AXIN2 ABCB1 CTNNB1 PMC9218441__F2 Intestinal strictures in Crohn’s disease: a 2021 update STAT3 IL13 OSMR ROCK1 APC GSK3B NOD2 RHO CTNNB1 PMC7575565__F6 RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells STAT3 RNF180 HGF PMC7019846__F2 Muscle protein synthesis and degradation signaling by omega 3 fatty acids (FA) TG ELF2 MTOR IRS1 EIF4E PMC7146513__F1 Specialized Pro-resolving Mediator (SPM) synthesis pathway and receptors GPR32 GPR37 FPR2 PMC10538533__F1 Updated roles of cGAS-STING signaling in autoimmune diseases CGAS IRF3 PMC6781272__F1 Generalized Toll-like receptor signaling mechanism, adapted from TBK1 TIRAP MAL TLR9 IRAK1 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 TLR10 PMC3303816__F3 Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis FBXW7 SIAH2 SEPT5 CASK PMC6224709__F4 Central carbon metabolism pathways in daf-2 and eat-2 mutants PCK2 ACO2 HEL-S-68p IAH1 FBP1 MDH2 PMC7393405__F1 Activation of the Main Innate Immune Receptors Involved in CVDs(A) Toll-like receptor (TLR) signaling pathway RIPK2 NLRP3 NOD2 NOD1 MYD88 PMC2799800__F1 Scheme of the model for the mammalian cell cycle CDC20 SKP2 PMC6178170__F10 Scheme showing a possible mechanism of the alleviated TLR-mediated inflammatory responses of macrophage U937 cells to the mycobacterial infection by coinfected A549 epithelial cells GSK3B MTOR TRAF6 MYD88 PMC4392729__F4 Th17 counteracts the effect of IL6 IL6 VEGFA IL5 PMC2948187__F1 Altered cellular pathways and processes in tumours RAN CBL EGFR PML RHO MTOR PMC8990939__F6 Prolonged exposure to simulated microgravity promotes stemness impairing morphological, metabolic and migratory profile of pancreatic cancer cells: a comprehensive proteomic, lipidomic and transcriptomic analysis CDC42 GLS HEL-S-133P HEL-S-162eP FASN ARHA HEL-S-30 PMC5779878__F6 The potential signaling pathways used by bufalin to induce apoptosis in SCC-4 human tongue cancer cells BAX PMC6590709__F5 Glycosylation in health and disease FAS EGFR TNF PMC8892604__F3 Deep Insight Into Regulatory T Cell Metabolism in Renal Disease: Facts and Perspectives GLS CD36 PMC5765504__F5 PPARG signaling HEL-S-273 SLC25A20 MLXIPL ADIG NUDT7 ACTA1 MGLL ACADM FGF8A CA3 NGF HADHB REN DGAT2 WNT1 ACADVL CPT2 KNG1 LPL MUC13 NR1i1 GPD1 ANGPTL4 PDK4 GPD2 THRSP TLR3 IGFBP5 DBI ELOVL6 CYBB PMC11790812__F3 Apoptosis of tumor cell induced by Dioscin BAX BAD ATM PMC11356641__F4 Signaling pathway involved in probiotics recognition TLR1 MAP3K7IP1 TIRAP IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC11790812__F4 Dioscin regulating autophagy in tumor cells MTOR PMC5409000__F6 Epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3), and Src-YES-associated protein 1 (YAP1) crosstalk STAT3 PXN EGFR RELA SRC TRAF2 PMC7822898__F6 Construction of lncRNA-related PPI networks linked to drug responsiveness in DLBCL STAT3 NFKBIA SOX2 BCL2 SETDB1 BCL7C MTOR EIF4E PMC6888083__F6 Mutual regulatory mechanisms among lncRNAs and miRNAs FGF8A BCL9 RNF4 DKK1 ZNRF3 APC2 E2F5 PMC7372134__F3 HO-1 dysregulation in cystic fibrosis (CF) GSK3B MAF HIF1A PMC7372134__F2 Hmox1 transcriptional regulation HMOX1 BACH1 KEAP1 GSK3B MAF HIF1A PMC5081262__F2 Major metabolic pathways in fatty acid metabolism: A) de novo lipogenesis and B) Polyunsaturated fatty acid metabolism SCD FASN GLA PMC3514907__F3 GeneGo “Cell Adhesion_ECM remodeling” pathway map MMP7 MMP16 EGF TIMP3 TIMP1 EGFR PLAUR PLG IGF2 MMP15 CD44 PLAT SERPINE2 IGF1 LAMA4 PMC4639852__F9 Human mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice STAT3 EGFR IL6 PMC11125634__F3 Schematic representation for DOCK11 and its partner AGAP2 regulating ARF1 activity to facilitate HBV retrograde trafficking ARF1 AGAP2 EGFR DOCK11 PMC11125634__F4 Proposed hypothesis explains the mechanism for the role of DOCK11 in HBV cccDNA formation and its modulation of histone modifications and RNA Pol II on HBV cccDNA CDC42 ATR PCNA DOCK11 PMC8204904__F5 Proposed signaling pathway that involves slit2/Robo2 and Nox2 activation during retinotectal pathfinding ROBO2 SLIT2 PMC2854285__F1 mTOR and cancer: many loops in one pathway RHEB TSC2 BAD TSC1 PTEN DEPTOR PMC10647618__F1 Canonical Hedgehog Signaling Pathway ADRBK1 SUFU GSK3B SMO PMC4199881__F1 Role of GKN1 in gastric cancer CASP8 COX2 CASP3 EZH2 GKN1 CTNNB1 PMC6471725__F6 Cinobufagin-induced effects on hepatocellular carcinoma Huh-7 cells with mutant p53 CDC2 BAX AURKA PCNA CCNB1 HNRNPK PMC5190133__F1 Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment BAX ING4 HMGA2 IGF1 FOXO1 EZH2 PTEN RUNX2 CTNNB1 FADD PMC3061066__F7 Model demonstrating the possible mode of action of hSSB1 RAD50 ATM MDC1 PMC5966718__F2 Detoxification of ammonia in the urea cycle and production of ornithine ASL OTC PMC9007670__F2 Pathophysiological Mechanisms Underlying Multiple Organ Dysfunction in Cytokine Release Syndrome GSDMD TRADD NLRP3 TRAF2 FADD PMC4287682__F1 MiR-15 family and its targets in the INSR signalling pathway ACLY RPTOR CRK BAD CBL GRB10 INSR STX4A PTEN IRS1 EIF4E PMC8110006__F4 Toward Colorectal Cancer Biomarkers: The Role of Genetic Variation, Wnt Pathway, and Long Noncoding RNAs SFRP4 WNT3 WIF1 PMC3227936__F1 EGFR signaling pathway EGF HBEGF TGFA GRB2 PMC8110006__F5 Toward Colorectal Cancer Biomarkers: The Role of Genetic Variation, Wnt Pathway, and Long Noncoding RNAs SFRP4 WIF1 PMC8110006__F3 Toward Colorectal Cancer Biomarkers: The Role of Genetic Variation, Wnt Pathway, and Long Noncoding RNAs PMC8258236__F2 Possible role of arsenic and gene-arsenic interactions in susceptibility to breast cancer: a systematic review SP1 IGF1 EGFR TERT IGF1R ATF2 PMC6600422__F2 Leptin receptor signaling is mediated by JAK-STAT, PI3K-Akt, and SHP2-ERK pathway STAT3 SOCS3 GRB2 IRS1 PMC4283135__F1 Canonical Notch signaling with points of intervention of current therapies ADAM10 NTM RBPJ PMC3392028__F3 Seven important signaling networks of osteoblast differentiation EPHB4 TGFB1 APC LRP5 ARHA RUNX2 FGF2 SOST SMURF1 BMP4 ADRB2 BMP2 ATF4 PTH PMC3392028__F1 Transcription factors and signaling involved in the osteoblast differentiation pathway SMAD1 DKFZp781O1323 EBP APC SMAD6 IHH RUNX2 MEF2C CTNNB1 HOXA2 STAT1 SMURF1 HOXA10 MSC ATF4 LEF1 HES1 MSX2 PMC9462519__F6 Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease RIPK2 TLR4 NOD1 IL1B PMC5364541__F8 Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway STAT1 STAT2 IRF9 OAS3 OAS1 OAS2 PMC4283135__F2 Notch signaling modules relevant for brain tumors TNC ITCH EGFR NUMB PMC4586474__F3 TGF-Beta-IDO-SHP axis TGFB1 IDO1 TLR4 RELB IRAK1 AHR PMC7193415__F8 GR Ser134 phosphorylation creates a feedforward signaling loop that potentiates further activation of the p38 MAPK pathway downstream of TGFB1 in TNBC models PIK3IP1 SMAD2 LEFTY2 SMAD4 KLF10 ATF4 PMC7764600__F2 Most important signaling molecules characterizing EBV + GC ARID1A CDKN2A EGF RCOR2 HGF EGFR PTEN MTOR PMC4586474__F1 Pathways of tryptophan metabolism HEL-S-90n IDO1 IDO2 PMC7764600__F3 Cellular degradation pathway of autophagy plays a fundamental role in immunity TLR4 TLR9 MTOR PMC2636986__F1 Adaptor protein containing pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain, and leucine zipper motif (APPL1)-mediated adiponectin and insulin-signaling pathways TSC2 TSC1 APPL1 ADIPOR1 RHOB MTOR PMC5853489__F3 DAL81 regulates expression of arginine metabolism in C. parapsilosis CPA2 CPA1 ARG1 ARG2 PMC6875424__F8 Possible mechanisms of the effects of methane against APAP-induced hepatic injury KEAP1 NQO1 APP PMC8245375__F5 Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity IRF9 RNASEL IRF3 IRF7 TRAF6 STAT1 TLR3 IFNAR2 TLR4 IFNAR1 MX2 MX1 TLR7 ISG15 PMC3032315__F3 Regulation of peripheral tolerance by the intrinsic and extrinsic apoptosis pathways in T and B cells BCR APC BCL2 BMF PMC3198933__F1 Toll-like receptor (TLR) signaling TBK1 MAL TLR9 TLR5 IRF3 TNF TRAF6 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC6473131__F1 Possible mechanisms of cancers caused by Porphyromonas gingivalis STAT3 MMP12 SOCS3 JAK1 IL1B PMC8687455__F7 Analysis of Wheat Wax Regulation Mechanism by Liposome and Transcriptome TG DGKA HEL-S-5 MGLL PMC8013702__F3 MuV infection of testicular somatic cells and downstream effects SOCS1 MX1 SOCS3 IL6 ISG15 CXCL10 PMC12145571__F2 Skeletal muscle atrophy is a multifactorial process that essentially results from a disturbance in the equilibrium between protein anabolism and catabolism SMAD1 DKFZp781O1323 IGF1 ULK1 SMAD2 SMAD4 BNIP3 MTOR PMC4179679__F3 Metabostemness: a metabolo-epitranscriptional switcher OGT SIRT1 SIRT6 PMC12085564__F7 Cardiomyocyte specific CD38 deletion protecting heart from acute myocardial infarction BAX SIRT3 MFN1 MFN2 BCL2 PMC6538211__F2 Illustration of the WNK-SPAK/OSR1-CCCs cascade in nervous and non-nervous system diseases WNK1 WNK4 HEL-S-62p PMC11727142__F9 Osteoblast‐Derived ECM1 Promotes Anti‐Androgen Resistance in Bone Metastatic Prostate Cancer SOS1 ENO1 GRB2 PMC4216607__F1 Management of Pediatric and Adult Patients with Medulloblastoma MAX APC SHH SMO MYC CDK4 PMC4706649__F2 Different apoptotic pathways are modulated by PEDF BAX CASP9 FAS CASP8 CASP3 BCL2 FADD PMC5906968__F1 Schematic representation of the regulatory pathways affecting gene expression during mouse spermatogenesis P1 AKAP4 PMC5279772__F6 Inhibition of NFKB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy CSA2 RELA FADD PMC4681408__F6 Patient-specific Immune States before Surgery are Strong Correlates of Surgical Recovery RPS6 HMGB1 TLR4 MAPKAPK2 RELA CD14 PMC10605590__F7 The potential non-genomic P4 action in colorectal cancer CXCR1 PGR PGRMC2 NENF PMC4693471__F2 Gene‐by‐age interaction miRNA–mRNA network analysis STXBP1 BOC AGAP2 PTF1A MED12 MAF NFKBIZ NOTCH1 ASB1 NTN1 ATOH1 NOTCH2 FOXG1 PPARGC1B FOXO1 MYCBP2 BCL2 CXCR4 BDNF VAMP2 CELSR3 SHANK3 ELF4 DCX SLIT3 NTF3 TEAD3 SIX3 SYP MSX1 GABPB2 CDH4 YAF2 DGKZ GAS1 MAML2 RAI14 SCA7 NRN1 ANKRD12 HMGB1 TRANK1 CPLX2 ABLIM3 TBX20 SEMA4F MTA2 USF1 NCOA1 TANC2 NR2A1 RTN4 SNAP25 LEF1 PMC2576563__F7 Tight regulation of MUC5AC mucin induction by pneumolysin via PAK4-JNK and MKP1 signaling pathways MUC5AC TLR4 PAK4 TRAF6 MYD88 PMC8510947__F2 STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function STAT3 COX2 MCU SOCS3 PMC10960729__F4 Activation and inhibition of the cGAS–STING signaling pathway in viral infection TBK1 CGAS TNF ENPP1 IL1B PMC10960729__F5 Tumor suppression and promotion of the cGAS–STING signaling pathway CGAS BRCA2 PMC10960729__F2 Triggers of cGAS–STING signaling pathway CGAS NONO PQBP1 PMC10960729__F3 Signal transduction mechanism of cGAS–STING TBK1 CGAS IRF3 PMC5874524__F8 LGM2605 inhibition of asbestos-induced NLRP3 inflammasome activation by blocking asbestos-induced reactive oxygen species (ROS) generation and activating the Nrf2-ARE pathway TXN NLRP3 KEAP1 NQO1 IL1B PMC8649885__F1 Schematic showing the reported genetic determinants of human EEA and EEAF MOS TUBB8 KHDC3L PADI6 NLRP2 TLE6 PMC5447385__F7 HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease HMGB1 TLR4 PHAX RAC1 PMC3521387__F9 ILOCi detected genes from T1D and their maps in 'type I diabetes mellitus' pathway IFNG HLA-DQA2 HLA-DRA PRF1 PTPRN2 TNF INS HLA-DQB1 PMC3521387__F7 ILOCi detected genes from BD and their maps in 'neuroactive ligand-receptor interaction' pathway LPA PLAT PRL LEPR HTR2A CALCR PMC3521387__F8 ILOCi detected genes from CAD and their maps in 'cytokine-cytokine receptor interaction' pathway POR SAG LTA FAS OSM PRL PMC11964952__F2 Proposed chart of T1D dual vulnerability initiated by Beta-cell metabolic dysfunction and CD4+ T-cell activation GLIS3 ATF3 CD80 GSDMD CTSH TXNIP APC GIP EIF2A XBP1 TYK2 PMC11964952__F3 T1D targets for therapeutic interventions in endocrine cells BAD TXNIP EGFR GCGR INS ARX SST GCG ALDH2 NKX6-1 HBEGF PDX1 NLRP3 CCND2 GIPR CDK4 PMC11964952__F4 T1D targets for therapeutic interventions in immune cells CD80 CD2 TXNIP MAFA CD69 APC CREM IL21R CD19 IRF4 TNF IFNG IGF1 DPP4 STAT4 PMC10378789__F2 Revisiting the Role of Autophagy in Cardiac Differentiation: A Comprehensive Review of Interplay with Other Signaling Pathways C6 ATG10 ATG3 ATG16L1 ATG12 ULK1 ATG14 BCL2 MTOR ATG5 PMC8773620__F1 Molecular Targeted Therapies: Time for a Paradigm Shift in Medulloblastoma Treatment? SUFU SHH SMO PMC4051158__F1 Role of the CD40–CD40L pathway during the CD8 primary response CD40 APC PMC8840228__F2 Muscle stem cell adaptations to cellular and environmental stress F2 ELF2 ATF4 PMC8840228__F3 Muscle stem cell adaptations to cellular and environmental stress TSC2 TSC1 EIF4E PMC9102653__F2 Subversion of the immune response of human pathogenic spirochetes MASP2 C1S C1R C4A C4B_2 CP PMC9330218__F3 Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer ACLY EGF RAX2 HMGCR EBP SCD FASN LDLR MTOR SIRT1 PMC4051158__F5 The CD40-CD40L pathway plays a critical role in CD4 T-cell–mediated IL-21 production during the rescue of exhausted T-cell response CD40 IL21R PMC7754534__F6 Proposed model of adenine-activated-hepcidin axis Adenine induces activation of cAMP/PKA signaling pathway, which in trun stimulates the activation of both SMAD1/5/8 pathways resulting in transcritional activation of hepcidin gene expression SMAD1 SMAD4 HAMP PMC3706439__F2 Fermentation of Xylose Causes Inefficient Metabolic State Due to Carbon/Energy Starvation and Reduced Glycolytic Flux in Recombinant Industrial Saccharomyces cerevisiae MAL ACD CIT PMC9382032__F7 Genetic and transcriptome analyses reveal the candidate genes and pathways involved in the inactive shade-avoidance response enabling high-density planting of soybean MAL SHE PMC4983807__F4 Members of receptor tyrosine signaling pathways that are predicted as indispensable nodes and targeted by cancer mutations, OMIM disease, viruses, or FDA-approved drugs RAF1 SOS1 SHC1 SMAD2 GSK3B PIK3R1 SMAD4 MAPK9 MYC MAPK8 MAPK3 MAPK14 RB1 EPHB2 CDK6 PDPK1 FGFR1 MDM2 MAPK1 VAV1 IRS1 HRAS ERBB3 IGF1 PAK1 MAPK7 CSK BCL2 RET CDC42 EGFR NFKB2 IGF1R INS TGFBR1 TGFBR2 RARA MAP2K4 INSR EEF1A1 CCND1 JUN KRAS RAC1 IGF2 NTRK1 ERBB2 DVL3 CREBBP JAK1 MAP2K1 LCK PMC5495464__F3 Interactions of IGF and ERB signaling pathways in malignancy STAT3 IGF2R EGF IGF1 EGFR IGF1R MTOR IGF2 IRS1 PMC4458429__F2 Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases SYK PXN CRKL MTOR SRC NEDD9 PMC9302318__F6 Network pharmacology analysis of molecular targets and related mechanisms of Guizhi decoction in treating of menopausal syndrome MAX ECSIT EGF RAN JUND FAS TRADD CD14 TNF FLNA HP NLK GRB2 TRAF2 PMC9302318__F7 Network pharmacology analysis of molecular targets and related mechanisms of Guizhi decoction in treating of menopausal syndrome SYK BAD GAL RBL2 CYC1 PTEN CD19 MTOR MYC RAC1 RHEB TSC2 BRCA1 BCR CD37 MDM2 GRB2 PMC8709142__F1 Beneficial Properties of Bromelain BAX BAD CCNC PMC6236434__F4 Mechanisms mostly deemed to contribute to the development of APAs TH KCNK5b CYP11B2 APC LRP5 NACA2 LRP6 ARHA LEF1 CTNNB1 PMC6535783__F1 RNF8 involves in DSB signaling pathway FAT10 L3MBTL2 DYRK2 CHD4 RAD51 JMJD1C RNF168 H2AX RNF8 ATM PALB2 MDC1 PMC11499591__F3 ApoM/S1P, Wnt/beta-catenin, and PI3K/AKT/mTOR signaling pathways involved in intestinal barrier damage SIRT3 SPHK1 MTOR CTNNB1 PMC4398256__F1 MTOR signaling and metabolic regulation RHEB ZAP70 MLST8 TSC2 RICTOR TSC1 FYN MTOR DEPTOR LCK PMC8466097__F2 Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer BAX BAD RECK PCNA MTOR APAF1 PMC8771504__F6 Chronic stress model simulated by salbutamol promotes tumorigenesis of gastric cancer cells through B2-AR/ERK/EMT pathway CDH2 PMC5308218__F4 Proximal Signaling Network of the BCR-ABL1 Oncogene Shows a Modular Organization SHC1 PPP1CC PIK3R2 PIK3R1 GNG12 NCK2 NEDD9 DOK1 TEC HSPD1 TUBA4A BCR CYFIP2 HEL-S-1 HEL2 ACTN1 NCK1 HEL-S-133P CAPZA2 CRKL PTPN11 YBX1 HGS CRK CAPZA1 MAJN CBL SH3BP1 ITSN2 PHGDH AVIL CD2AP RAPGEF1 LRRK1 CAPZB NCKIPSD CSK NCKAP1L CPNE2 WASF2 EPS15L1 GRB2 HEL-S-87p STAM2 GAB2 YWHAZ PMC3257580__F1 Kruppel-like factors in lymphocyte biology KLF4 KLF3 KLF2 KLF10 KLF13 PMC12081410__F11 Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway PCNA PDPK1 CDK2 CDK4 PMC6527596__F1 The regulatory mechanism of miRNAs in TLR signaling SNAP23 SOCS1 TLR9 IRAK1 IRAK2 TRAF3 TNF TRAF6 MYD88 TLR1 TLR3 NFKB1 TLR4 IRAK3 TLR8 TLR7 TLR10 IL1B SOCS6 PMC11653707__F1 MTOR signaling in activating TME cells RHEB TSC1 EGFR MTOR JAK1 PMC3518582__F3 Wnt7a signals bidirectionally through divergent pathways to influence both presynaptic and postsynaptic assembly and to promote excitatory synapse formation and function MAP1B GSK3B WNT7A PMC6363035__F3 Schematic Representation of DDR1-collagen signaling pathway in cancer CDH2 RPS6 STAT3 COX2 SRC HES1 TM4SF1 PMC3518582__F1 Wnt Signal Transduction Pathways MAP1B APC LRP5 LRP6 RHO CTNNB1 PMC5357236__F1 microRNAs in lipoprotein metabolism and cardiometabolic disorders ABCG1 ABCB11 CYP7A1 ABCA1 PMC3710321__F1 Regulation of STATs by polycystin-1 and their role in polycystic kidney disease STAT3 STAT1 EGF HGF IL13 IL4 SRC PMC3124048__F1 Parallels in haematopoiesis between the Drosophila LG and mammalian bone marrow CDH2 PMC9366230__F8 Cell membrane coated-nanoparticles for cancer immunotherapy PIR PMC5392015__F4 GHRP mechanism of action TGFB1 IGF1 CD36 MTOR ACE2 PMC10671516__F3 Granulosa cell glucose and lipid metabolism on oocytes CCS HEL-S-133P LDHB ADFP PMC11988865__F6 Regulatory mechanisms of Brandt’s vole brain tissue in response to hypoxia KLF4 HDAC1 BAD HEL-S-68p HEL-S-49 PTEN PMC7723926__F1 Schematic depiction of unfolded protein response (UPR) signaling cascade, and the interplay between endoplasmic reticulum (ER) stress response and inflammation RTCB NLRP3 TXNIP ATF4 IL6 EIF2A XBP1 PMC3759367__F11 Signaling pathway and proposed sites of arsenite perturbation KRT1 EGF KRT10 SMAD1 FOXN1 DKFZp781O1323 SMAD4 DUSP2 NOTCH1 PMC3158097__F1 Association Analysis of Canonical Wnt Signalling Genes in Diabetic Nephropathy APC GSK3B CTNNB1 PMC10671516__F1 Paracrine-mediated signaling between granulosa cells and oocytes BMP15 BAX PTX3 CASP9 SMAD1 STAR DKFZp781O1323 SMAD2 HAS2 GDF9 PMC3638465__F1 Metabolic map showing selected pathways of D CBL SLA FES PMC5983649__F1 Schematic overview of Annexins at the crossroad of late endocytic pathways RHEB NPC1 STARD3 STX6 SLC38A9 PMC3737723__F8 Model of the Prdm1a gene regulatory network for NCC specification FOXD3 TFAP2A NPB GRN SOX10 PMC8508234__F9 Therapeutic and Prognostic Values of LSM Family Genes in Breast Cancer RAN APC ATM CYC1 HCTP4 PMC6895975__F2 Extracellular regulation of mesendodermal gene expression DAND5 BMP4 SMAD4 NODAL NDP PMC3070849__F1 Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation SYK BTK FOXO1 PI3 BLNK CD19 PTEN IRF4 IRF8 JAK1 PREB AID PMC4020801__F3 Proteomics of Vitreous Humor of Patients with Exudative Age-Related Macular Degeneration ALB SERPINC1 HEL111 DDN SERPINA1 HRG FGA GPX3 PMC4441360__F6 EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met+ Hepatocellular Carcinoma ERBB3 TGFA EGFR PMC7746484__F1 Toll-like receptor (TLR) signaling pathways TIRAP TLR9 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR7 PMC9516464__F2 Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease CXCL9 BAX IL25 TLR3 MSC ARG1 PMC4250281__F1 Cellular signaling through pre-organized and inter-connected nanocluster assemblies with gel-like properties CDC42 EGFR APC IQGAP1 GRB2 MTOR RAC1 CTNNB1 S100B PMC9304635__F2 Diosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis PCSK9 LPL TG ABCG8 ABCG5 CES1 CD36 NPC1L1 CYP7A1 LDLR ABCA1 SIRT1 PMC8797823__F5 Frizzled receptor expression on patients’ survival with gastrointestinal cancers: A systematic review with meta-analysis APC CSK RHO RAC1 PMC5983650__F9 Bornyl cis-4-hydroxycinnamate-induced apoptotic pathway BAX HEL-S-99n BAD ATF4 EIF2A PMC8799916__F2 Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures BAX BAD FYN EGFR SMO SRC GLI3 PMC11568601__F9 Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway XBP1 PARP1 PMC4673555__F4 Proposed GC-C signaling in colitis CDX2 NR2A1 PDE3A GUCY2C SLC9A3 CFTR GUCA2B HNF1A PMC7684869__F2 Schematic figure of NPY and leptin in local homeostasis of bone remodeling ADRB2 NPY PMC5454045__F2 FGF signaling pathway ETV5 JUN ETV4 FOS PMC6523677__F2 MicroRNA-mRNA network constructed using CyTargetLinker CDA RRM1 RRM2 DCTD PMC3342058__F2 Major therapeutic targets for inhibition of donor-reactive memory T cell responses ICOS CD80 CD27 TNLG8A HEL-S-171mP MTOR PMC6775293__F8 Pathway of Alzheimer's disease LPL IDE CASP9 BAD CASP12 APOE IRF1 TNF CASP3 APP CA9 APAF1 FADD PMC4178318__F10 Schematic of Rab23 functions in chondrogenic cells SOX9 RAB23 PMC4837341__F4 Drug target identification using network analysis in Sini decoction GLDC CAD PLA2G3 FADS2 MIOX CDIPT PISD DAO ASPA PLA2G10 LPCAT4 AGXT PEMT ASNS GCK HEL-S-87p PMC9271168__F2 C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways PPM1D LONP1 MAFK KEAP1 DDIT4 PPM1G AMOTL2 HIF1A PPP1R15B XBP1 ERN1 HSF2 GCN1 MDM4 EGLN1 EIF2AK4 DNAJC3 CEBPG ATG3 ADM2 HSF1 CHEK2 ATM ATF4 EIF2A MDM2 ATG5 TAOK1 JUN ATG16L1 SYVN1 EIF2AK1 ELF2 VHL TP53BP1 ATG101 ATG10 ATG12 CDKN1A NFE2L2 ASNS NCL PMC7330693__F8 GINS2 interference induces apoptosis and cell cycle arrest GINS2 CCND1 CDK4 PMC7382369__F4 Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS TSC2 CAD TSC1 UMPS DHODH PMC3168773__F2 Functional relationship linking Crb proteins to the SWH pathway CRB3 SMAD2 PMC9655342__F3 Targeted Therapies in Advanced and Metastatic Urothelial Carcinoma ERBB3 RHEB TSC2 TSC1 ERBB4 PAK1 FGFR4 FGFR1 FGFR3 MDM2 GRB2 FGFR2 PMC8971665__F4 Retinoblastoma Protein Paralogs and Tumor Suppression TF CCND3 RBL2 RB1 RBL1 CCNE2 CDK6 CCNE1 CCND2 CDK2 CDKN3 CCND1 CDK4 PMC6232344__F3 Compounds and hitting targets on ICH BAX CASP9 NLRP3 TLR4 PMC6039985__F3 In PDA cells, E47 directed an integrated program of gene expression that controlled cell-cycle progression MIA HEL-S-162eP XPC PMC2939298__F1 Schematic diagram of androgen biosynthesis HSD3B2 HSD17B3 CYP17A1 CYP11A1 RDH5 AKR1C2 PMC7956267__F2 Transcriptional regulation involved in activating salt stress-responsive genes in rice MYB ERF CTCF PMC6557283__F2 YAP/TAZ signaling and resistance to chemotherapy CSF2 CSF1 CXCL5 IL8RB CSF3 PMC6557283__F1 YAP/TAZ signaling and resistance to targeted therapy BRD4 TBK1 AXL EGFR TEAD4 LATS1 ERBB3 LATS2 TEAD2 TEAD3 GRB2 NF2 MOB3B PMC7291251__F1 Upstream and downstream mTORC1 signaling RHEB MLST8 TSC2 TSC1 ULK1 TBC1D7 MTOR DEPTOR PMC5642500__F7 HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma ERBB3 EGFR GRB2 MTOR VHL PMC5051268__F2 Multiple Faces of FGF-23 CYP27B1 FAM20C DMP1 FGFR1 PTH ACE2 ENPP1 FGF23 PMC4312599__F5 Coordinately up-regulated genes of WNT signaling pathway in HCV versus HIV BAMBI RBX1 SOST SIAH1 ROCK2 APC CER1 SMAD4 SKP1 ARHA NLK CTNNB1 PMC9366716__F2 Cell wall and the response and tolerance to stresses of biotechnological relevance in yeasts ST14 HMFT1766 MID1 PMC7344072__F2 Mechanism by which proinflammatory cytokines in the OA knee joint stimulates MSCs to produce IDO1 STAT1 IDO1 BIN1 PMC2603552__F10 Role of oxysterol sulfation in lipid metabolism FAS SULT2B1 ABCA1 STS PMC4346193__F5 Schematic model illustrating how IGFBP-3 proteins regulate the TNFA and apoptosis pathway in REC: Right TIMP3 TNF PMC11979195__F2 Modulating oxidative stress: a reliable strategy for coping with community-acquired pneumonia in older adults KEAP1 MAF PMC3103151__F1 Intracellular pathway of folate metabolism with highlighted critical pathways of methotrexate (MTX) entry, effect and efflux RFC1 ABCC3 GGH HEL-S-70p ABCC2 FPGS ABCB1 ADA PMC5992473__F9 Schematic Illustrates a Model of miR372 Promotes Liver Cancer Cell Growth by Upregulating erbB-2 through Enhancing YB-1 via Targeting for PTENmiR372 accelerates malignant progression of liver cancer cells in vitro and in vivo CTCF ERBB2 CDK2 PTEN TCF4 CTNNB1 PMC8616315__F2 Multiple Interactions of RUNX with the Hippo–YAP Pathway LATS1 LATS2 RUNX3 PMC6528874__F1 Anti‐tumour effect of TNFA and IFNG alone and in combination IFNG TCP1 FAS PMC3382253__F4 Mitochondria biogenesis allows tissue adaption under stress SMAD2 SMAD4 PMC10750205__F2 Endosialin in Cancer: Expression Patterns, Mechanistic Insights, and Therapeutic Approaches MMRN2 CLEC14A PMC3382253__F3 Mitochondria are central organelles in determining cell fate in liver diseases BAX APAF1 FADD PMC8899336__F1 Wnt signaling in biliary development, proliferation, and fibrosis APC RHO LEF1 CTNNB1 PMC7785817__F2 Structures of Slit/Robo, and the Slit-Robo signaling pathway CDC42 CDH2 SRGAP1 ARHA CTNNB1 PMC8899336__F2 Wnt signaling in biliary development, proliferation, and fibrosis FGF7A HGF BMP4 PMC2548289__F1 Hereditary Hemochromatosis in the Post HFE Era TFR2 HFE HFE2 PMC9562887__F2 “Sweet Spot” of Targeting Tumor Metabolism in Ovarian Cancers STAT3 PTEN MTOR PMC5548184__F4 Heterogeneous ribosomes preferentially translate distinct subpools of mRNAs genome-wide APRT GPHN BAD FAS NAPRT CTSH TCN2 PML AIRE AMN MTTP RTN1 BOK APP PKN3 ATN1 PCTP S100A13 CUBN SRGAP2 ARG2 CIT SRGN ELAC2 AAMP PTN EGR1 LIMK2 APOE RERG ATG10 UBE2H SERPINE2 PDGFRA MAPK7 HEL-S-102 RPS25 LYN GATA4 PMC3437636__F2 Formation of the NFKB-stimulating TNFR1 signaling complex TRADD TRAF2 FADD PMC8516864__F4 Tryptophan/kynurenine pathway TH HEL-S-90n KYNU KMO PMC8516864__F2 Polyamine pathway and Cadaverine pathway SMS SRM ASNS PMC4353374__F2 SIRT1 in synaptic plasticity LIMK1 YY1 MTOR BDNF SIRT1 PMC7484393__F3 Correction: Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission NLRP3 TLR3 TLR8 IRF3 IRF7 TLR7 TNF IL1B MYD88 PMC11126064__F8 Hepatoprotective Effects of Allicin on Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Oxidative Stress, Inflammation, and Apoptosis BAX NQO1 TNF PMC8063048__F1 Roles that dopamine receptors play in regulating inflammasome formation as well as NFKB pathway HEL-S-101 NLRP3 HEL-S-69p PMC8063048__F2 Roles that dopamine receptors play in macrophages STAT3 IL4 IL2 PMC6666404__F4 Longitudinal multi-omics of host–microbe dynamics in prediabetes TG IL10 GLS tmp_locus_29 WAS SNCA APP HEL-S-11 PMC5418445__F1 Tumour angiogenesis: molecular pathways and potential interventional strategies HGF RHO RAC1 PMC10940030__F4 Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases SYK FYN ARF1 RHO MTOR SKI GAB2 PMC4538325__F3 Signaling pathways modulated by electrophilic lipids KEAP1 HSF1 MAF PMC6321423__F3 Schematic depiction of the TGFB signaling pathway STAT3 SMAD2 SMAD4 TGFBR1 PMC8618532__F2 Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function SIRT3 BATF IL4 MTOR SIRT1 PMC7718329__F7 TET1 and 5hmC in an obesity-linked pathway driving cancer stem cells in triple-negative breast cancer TARDBP TET1 PMC8740020__F3 Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug Design SOCS1 SOCS3 EIF2A PMC3686733__F2 Proteomic View of Interactions of Shiga Toxin-Producing Escherichia coli with the Intestinal Environment in Gnotobiotic Piglets HEL-S-133P GALP ASPA PMC2575825__F9 Redox-sensitive steps in hypothetical redox signaling pathways NOX5 TGFA IGF1 TLR4 EGFR PTEN SRC PMC7041777__F3 Interactions between AB, WNT pathway and energy metabolism in AD PDHX HEL-S-133P APC LRP5 LRP6 CTNNB1 PMC8740020__F2 Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug Design ATF3 ELF2 ATF4 XBP1 PMC2575825__F4 Glutathionine (GSH) redox network HRAS HAGHL GLRX2 RBP1 EGFR CFTR PTGES PMC3739939__F4 Pathway analysis showing integration between signaling pathways, transcription factors, and adhesion genes SNAI2 HEL113 SNAI1 TWIST2 ZEB2 SOX10 TWIST1 PMC6933333__F7 LncRNA TNRC6C‐AS1 silencing inhibits proliferation and promotes apoptosis and autophagy of TC cells LATS1 LATS2 STK4 PMC5516868__F1 Snf1 pathway and its components NRG2 NRG1 GAL TPK1 SIX5 C2 HSF1 PMC9042615__F7 Maresin 1 Alleviates Diabetic Kidney Disease via LGR6-Mediated cAMP-SOD2-ROS Pathway IL16 LGR6 PMC4564008__F1 Regulation of Hedgehog signaling by ubiquitination SUFU PTCH1 PMC8076792__F1 Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors? FAS CCL18 NPC1 SCD FASN DHCR24 ABCA1 NPC2 ABCG1 HMGCR CYP46A1 FOXP3 IL1B PMC8514848__F1 RASopathies: From germline mutations to somatic and multigenic diseases ARAF BAX CBL SPRED1 ECD NF1 BRAF BCL2 CS MTOR APAF1 PMC3798821__F6 The ILK signaling and its putative regulation by the micro-RNA-1 (miR-1) SNAI2 PARVA HEL-S-28 MYC CCND1 PMC8787047__F3 Accentuating CircRNA-miRNA-Transcription Factors Axis: A Conundrum in Cancer Research CDH2 BAX CDK6 FOXO3A SMAD2 USF1 SMAD4 YY1 MTOR CDK4 PMC3798821__F4 The valine degradation pathway from the differentially regulated genes in response to 3–7 days of mechanical overload KLF15 EHHADH HADHB BCAT2 DBT DLD PMC6889001__F2 Atherothrombosis and the NLRP3 Inflammasome – Endogenous Mechanisms of Inhibition SIRT3 NLRP3 TLR4 IL18 PTMS PMC3872295__F1 Mechanistic model to show how mechanical forces promote differentiation of fetal type II epithelial cells via release of soluble growth factors HB-EGF and TGFA with subsequent binding and activation of the EGFR and ERK signaling pathway HBEGF TGFA ADAM17 EGFR PMC9298356__F1 CAM photosynthesis: the acid test HEL-S-62p CS PMC6595533__F2 The proposed mechanisms by which norepinephrine (NE) and corticosterone/cortisol (CORT) regulate sterile inflammation CORT IL1R2 IL1R1 HMGB1 XCR1 NLRP3 CX3CR1 CR1 PMC8471002__F4 Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models LATS1 LATS2 SMAD2 HEL-S-28 ARHA PMC3334885__F1 T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice HEL164 TGFB1 NUSAP1 PKIG TTK LSR CENPA TSPYL2 PGRMC1 LBR PMC5334311__F1 The compensatory B‐cell proliferative signaling network mediated by insulin resistance TSC2 TSC1 CCND2 GSK3B PMC8471002__F2 Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models MAP3K7IP1 TLR4 HEL-S-28 ARHA TRAF6 IRAK4 IL1B MYD88 PMC8471002__F1 Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models SMAD2 APC SMAD6 SMAD4 CTNNB1 PMC8204080__F1 O-GlcNAcylation in Hyperglycemic Pregnancies: Impact on Placental Function OGA OGT GSK3B IRS1 PMC10999050__F3 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis STAT3 BAX CASP9 CASP8 TNFSF6 PTGS2 TNF MYC CDKN1A FOXO1 RELA PRKCA CASP3 CALM1 CCND1 IL1B PMC7699474__F3 Protein interaction networks (PPIs) for ploidy associated c-MYC -interacting bivalent genes NTS PBR BLNK MYC PMC8961648__F4 Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast HEL60 GAD1 ARG1 PCK1 HEL-S-26 PMC8177011__F7 Expression of Nutrient Transporters on NK Cells During Murine Cytomegalovirus Infection Is MyD88-Dependent HEL-S-92n IL33 MYD88 PMC5955790__F1 Tumor necrosis factor A (TNF) regulation in health and disease and its sleep-linked effectors and actions IL10 IL37 CRH GHRH IL4 IL6 TNF PMC6610925__F1 Hexosamine biosynthetic pathway OGA OGT PGM3 PMC4615139__F6 Proposed mechanism of cordycepin-induced apoptosis and cell cycle arrest in NB-4 and U937 cells CDK2 CCNA2 PMC6610925__F3 Hexosamine extended and salvage pathways OGA OGT GNE NAGK PMC6610925__F4 HBP regulates multiple proteins in cancer cells via OGT OGT FH H2AX FOXO3A ATF2 MTOR PMC8457844__F2 Classically known renin angiotensin pathway and the inhibitors identified from our high throughput screen AGTR2 AGTR1 PMC8571027__F4 Arginine methylation negatively regulates the anti-viral response TBK1 PRMT7 CGAS MAVS PRMT3 PRMT6 IFI16 IRF3 PMC5084027__F4 AMP-activated protein kinase (AMPK) signaling pathway MLYCD RPTOR SLC2A4 ADRA1A FASN TBCD MTOR INS ADRB3 EEF2K HMGCR INSR GYS1 EEF2 LIPE CFTR SRC CPT2 PMC6794370__F7 Mitochondrial dynamics in cancer FIS1 OPA1 MFN1 MFN2 MIEF1 MFF MIEF2 PMC6794370__F2 Mitochondrial physiology CYB PDC FES PMC9439649__F4 CAR T-Cell Therapy for Patients with Multiple Myeloma: Current Evidence and Challenges TSC2 BAD TSC1 CCNE1 MCL1 BCL2 ATF2 MDM2 MTOR CCND1 FOS MEF2C PMC12124620__F4 A) The role of notch signaling pathway in the aging of MSCs CCND1 HES1 PMC9526582__F2 Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer NTS HEL113 ALPL TGFBI THSD4 IGFBP2 MYLK FYN CASK ABCC2 CEMIP CADPS FCGBP TMEM200A TFF3 TMPRSS3 IGF2 DAZL NRXN3 HSPB3 SOHLH2 POTEE KIFAP3 SPANXD MAGEA2B HPDL MVP PALLD ASB9 SSPN CDK14 CD200 SERPINB2 APBB2 CD68 PF4 PMC4592163__F1 Endoplasmic reticulum stress inducing autophagy ATF4 EIF2A PMC6098222__F2 Stimuli-induced TLR2- and NOD2- mediated signaling LTA MAP3K7IP1 TIRAP MAL NOD2 TRAF6 MYD88 PMC2715236__F6 Model for the role of FANCM in the DNA damage response FANCD2 FANCM FAAP24 PMC5385391__F9 HMGB1 release regulated by the PLCG1–IP3R–SOC signalling pathway during calcium overload in hepatocytes HMGB1 ORAI1 STIM1 PMC9537025__F1 Mass spectrometry-based approaches to explore metabolism regulating ferroptosis LOX GPX4 GCLC LPCAT3 FACL4 DHODH PMC4047366__F11 Metabolic feedback via HBP and N-glycan branching MGAT5 MGAT1 MGAT2 GCGR PMC8889000__F3 Autophagy: a multifaceted player in the fate of sperm RHEB IFT20 KIT GOPC RAB1B PICK1 GJA1 RAC1 SIRT1 NANOS2 PMC7500163__F1 Pathways expressed during humoral immune response of SARS-CoV-2 infection VEGFC TRIM25 NFKBIA ATF4 MDM2 MMP9 VEGFA KITLG CD6 PMC7017144__F10 Pathway signaling network generated from the genes located within the top 100 DM tiling regions CDC42 ARVCF FBXL17 IRF2BP1 RAN IRF2BP2 VRK1 CREB5 PXN FGF21 PAK4 SMAD4 ATF2 DST CTNNB1 ERBIN CTNND2 STAT1 KCNB1 PLAT PRKCE CSNK2A2 ROCK1 CSNK2A1 ATM SRC POLE CCND1 SNAI2 ADAM19 JDP2 CCL11 GDNF ERBB4 NR3C1 ERBB3 FKBP5 NRG1 PLK3 HPGD SUFU IRF2 ERBB2 LYN ITGB5 TWIST1 ARHGAP24 ITSN1 PMC3715061__F1 Hedgehog signaling, vismodegib action, and acquired resistance PTCH2 SUFU PTCH1 SMO GLI3 PMC8652134__F3 Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease TG HEL-S-128m PCK1 NOTCH1 PMC5568783__F2 PERK arm of the unfolded protein response BAX BCL2 EIF2A XBP1 PMC4051800__F6 Causal BN learned from breast cancer cases for the ErbB pathway PIK3CA RAF1 SOS1 PIK3R2 PIK3R1 MAPK9 MYC NRG4 MAPK3 EREG PLCG2 PRKCA BTC NRAS SRC MAPK1 NCK1 CRKL AREG HRAS ERBB3 NRG2 CRK HBEGF SOS2 PAK1 CDKN1B MAPK10 GRB2 EGF BAD TGFA ABL2 PIK3R3 EGFR AKT3 BRAF NRG3 SHC2 NCK2 PLCG1 CBLC SHC3 JUN ERBB4 EIF4EBP1 KRAS ARAF NRG1 CBL CAMK2D ERBB2 MAP2K2 CAMK2G PMC2100400__F2 Innate and Adaptive Immune Response to Apoptotic Cells CRP MFGE8 PC PMC5568783__F1 IRE1A arm of the unfolded protein response BAX NLRP3 TXNIP IL16 XBP1 UNK PMC3735949__F3 Comparison of gene expression in RAW264.7 (RAW) and TGEM cells treated with KLA for the TLR4 signaling pathway TBK1 TNFAIP3 TIRAP RELB IRAK1 TRAF3 IRAK4 IKBKG CTRL LY96 COX2 TICAM1 IRAK3 RIPK1 IFNA1 NOS2 CASP8 TICAM2 MAL CD14 IRF3 IRF7 PTGS2 IL1A TNF RELA IKBKB MAP3K7 MAP2K1 VCAM1 MAP2K2 IFNB1 REL NFKBIB FADD PMC3983408__F7 Mechanism of immune dysfunction in Huntington’s disease IRAK1 IL6 IRAK4 PMC3887194__F13 Schematic modeling of the TcpB inhibition of TLR4 signaling TLR4 MAL MYD88 PMC5762524__F3 Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus ECSIT JUN FAS EGFR CD14 ATF2 TRAF6 FLNA MEF2C MOS NLK GRB2 TRAF2 PMC6378226__F1 Cell death pathways currently implicated in motor neuron cell death in ALS and related miRNAs BAX CASP9 FAS CASP8 MLKL CASP3 FADD PMC4031100__F3 Nutritional metabolomics: Progress in addressing complexity in diet and health SLC6A12 OMP SLC25A13 MAL PMC10453317__F2 GAB1 recruitment modes to activated receptors and major GAB1 signaling pathways CRK GRB2 PMC4292994__F3 Host genes with reproducible microbiome associations across cohorts MAPK14 STAT3 HEL-S-71 MAP3K7IP1 RIPK2 IL12A TXK NOD2 DAP IL12B IL23A IKBKG PMC4630209__F2 KIT-mediated signaling events BTK FYN KIT LYN GRB2 GAB2 PMC8166497__F5 N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis MAF HRK PMC11077654__S1 Cerebrospinal Fluid Dysregulation via a SPAK and OSR1 Targeted Framework Nucleic Acid in Hydrocephalus CSF1 OSR1 PMC4890577__F1 Bile acid signaling in murine hepatocytes EGR1 S1PR2 PMC8166497__F4 N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis BTK APP ACR PMC312639__F9 Proposed model for RhoA signaling to the c-jun promoter CDC42 ARHA RHO PMC4079737__F1 Molecular Pathways: Niches in Metastatic Dormancy BMPR2 AXL BCL2 BMP7 PMC7285711__F3 Interaction network analysis of the (A) visceral obesity pathway and (B) the cell cycle pathway, using the path designer of IPA RB1 CCNE1 TFDP1 THRAP3 SHOX2 CCNH PMC5452017__F2 Brain metabolism in health, aging, and neurodegeneration PDK4 F2 APC PMC5115734__F5 Evolution of the Tetrapyrrole Biosynthetic Pathway in Secondary Algae: Conservation, Redundancy and Replacement CPOX FECH UROD UROS PMC5452017__F3 Brain metabolism in health, aging, and neurodegeneration ACLY HMGCS1 AACS PMC9285394__F6 Vascular smooth muscle cells in the development of aortic aneurysms and dissections TGFBR2 MYLK ACTA2 FBN1 SMAD2 SMAD4 TGFBR1 PRKG1 PMC5452017__F5 Brain metabolism in health, aging, and neurodegeneration TFAM SIRT3 BDNF NRF1 PMC9645596__F1 TGFB: Signaling Blockade for Cancer Immunotherapy SMAD2 USP11 SMAD4 RHO TRAF6 TGFBR1 TGFBR2 TRAF4 SMURF1 USP15 USP4 GRB2 SMURF2 PMC3812160__F7 Transcriptome-Wide Mapping of Pea Seed Ageing Reveals a Pivotal Role for Genes Related to Oxidative Stress and Programmed Cell Death UBC PRX LRSAM1 PMC3693914__F2 DA biosynthesis and degradation TH PMC524522__F9 Mapping molecular correlates of aggressive mesothelioma to highly curated molecular pathways can identify the underlying molecular mechanisms of the disease BTG2 RXRA WEE1 ADA PMC9433080__F1 Treating non-small cell lung cancer by targeting the PI3K signaling pathway RHEB CASP9 TSC2 BAD RAD51 TSC1 FOXO1 FOXO3A CHEK1 PTEN RHO MDM2 PMC3792429__F1 Hierarchy of nucleolar stress-induced neuroprotection PTEN MDM2 MTOR NCL PMC4227423__F2 Differentially expressed genes in the proteasome pathway RPN2 CS POMP ING1 RPA1 PMC4111284__F1 IGF signaling pathway IGF2R IGF1 GHRH IGFALS IGF1R GHRHR GHR IGF2 SST PMC6700399__F1 Inflammatory pathway centered upon TNF in the process of NASH-HCC development STAT3 STAT1 ROS1 TLR4 TNF PMC6023281__F3 Neuroprotection and the PI3K/AKT/PTEN/GSK-3B pathway and SODs GSK3B MAF PTEN PMC5801575__F5 Proposed biosynthetic pathways of Cat315+, Cat316+ and WFA+ aggrecan GAL OTX2 CS PMC7886076__F4 PTEN signalling in other major oncogenic pathways PTEN PLAC1 FURIN CTNNB1 PMC3735949__F4 Comparison of the gene expression and eicosanoid metabolite changes in RAW264.7 (RAW) and TGEM cells treated with KLA is shown for the arachidonic acid metabolism pathway CTRL ALOX5 PLA2G6 PTGS1 PLA2G5 PTGES PTGS2 PLA2G4B PMC2768990__F2 BANs of differentially expressed genes in common between cell lines FGF8A SSBP2 GLIPR1 PIK3R3 DHFR DKFZp686P11128 IFI16 CADPS2 SLC26A2 LIPG FXYD3 PMC3735949__F5 A comparison of gene expression and lipid metabolite changes in RAW264.7 (RAW) and TGEM cells treated with KLA is shown for the sterol biosynthesis pathway CTRL HMGCR SOAT2 SQLE SC5D DHCR24 CH25H DHCR7 PMC5801404__F2 Mechanistic map of the signaling pathways involved in local translation mediated by class I mGluRs in neurons DGKK EEF2K MAP1B GRIP1 GSK3B PC ARC MTOR EIF4E PMC9152184__F2 Update in TIGIT Immune-Checkpoint Role in Cancer CD226 TIGIT IRF4 FOXP3 GATA3 PMC3735949__F6 Changes in the genes and processes related to mitochondrial metabolism in RAW264.7 and TGEM cells treated with KLA FAS CLYBL CPT2 PMC198547__F8 Leptin action on the TRH neuron STAT3 POMC MC4R NPY AgRP PMC2908768__F4 Cytokine signaling through the Jak/Stat pathway in mammary gland development SOCS1 SAA1 OSM IL13 PRL OSMR IL4 SOCS3 PMC11655924__F3 High glucose in diabetes enhances Wnt-stimulated nuclear accumulation of Beta-catenin APC ROR2 LRP5 LRP6 RYK ARHA CCND1 LEF1 CTNNB1 PMC3092522__F1 HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies PTEN IGF1R MTOR PMC11655924__F1 Anomaly of the insulin-signaling pathway RHEB TSC2 TSC1 RAF1 SOS1 GRB2 MTOR SHE IRS1 PMC5663718__F3 Periodontitis caused by defective killing of bacteria PLG CCR4 CCL2 PMC11655924__F2 Adrenergic signaling at the crossroads of diabetes, obesity, and cancer ADRB3 ADRBK1 TRIB1 IRS1 PMC6060254__F1 lncRNAs involved in the IFN antiviral response TBK1 CGAS IFI6 MAVS IRF9 IFIT1 IFITM1 IRF3 IRF7 CMPK2 RSAD2 GBP1 MYD88 TLR3 USP18 IFITM3 OASL MX1 TLR7 ISG15 JAK1 OAS1 TYK2 PMC8034148__F2 Regulatory mechanism of necroptosis RIPK3 TRADD MLKL RIPK1 CYLD FADD PMC7237193__F7 Regulatory network of let-7 is associated with the metabolism of glucose, fatty acids and amino acids in the silk gland TH PC CP PMC9502527__F2 Molecular Pathways of WRKY Genes in Regulating Plant Salinity Tolerance SOST MYC PMC11703377__F1 Remodeled fatty acid metabolism in tumor cells ACLY SCD EGFR FASN HEL-S-5 MTOR VHL PMC8222901__F2 Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity TRIM31 TBK1 TRIM38 TRADD MAVS HCGV IRF3 TRAF3 TRAF6 MYD88 CACTIN RIPK2 NLRP3 TLR3 TLR4 NOD2 TRAF5 TRAF2 PMC3078523__F2 Heme Oxygenase-1, a Critical Arbitrator of Cell Death Pathways in Lung Injury and Disease BAX BAD PMC3953959__F6 Regulation of TFs activity by degradation modulated by H2O2 TF KEAP1 ATM MDM2 PMC7248300__F2 HCMV encoded proteins which help to evade CD4+ T cell mediated immune responses CGAS MHC2TA PMC9507777__F4 Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma PDC IL6 MIF PMC4941299__F8 Involvement of SULF2 in Gamma-irradiation-induced invasion and resistance of cancer cells by inducing IL-6 expression STAT3 SULF2 CTNNB1 PMC8120474__F8 Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis GSK3B NFATC1 CTNNB1 PMC5437908__F2 Predicted synthesis pathway for the t6A modification and its derivatives in H GON7 YRDC TRMO CDKAL1 PMC5911724__F5 PI3K–AKT signaling pathway MYB SYK BAD CREB3 RAF1 MCL1 AKT3 CRTC2 PTEN MYC PCK1 CSF3 CSF3R BCL2L1 YWHAQ PHLPP2 PDPK1 PPP2R3B MTCP1 CHUK MDM2 CCND1 MAPK1 CASP9 GNB5 TNFSF6 RBL2 PIK3AP1 CD19 RAC1 IRS1 BRCA1 GYS1 FOXO3A NFKB1 CDKN1B RXRA BCL2 MAP2K1 CDC37 GRB2 PMC6908429__F4 Tetherin blocks virus release, activates an innate immune response and is counteracted by Vpu or Nef SYK CXCL10 TRAF6 TRAF2 PMC7582160__F4 Details of unfolded protein response activation in the venom gland PPARG CANX CD82 VCP MBTPS1 XBP1 INSIG1 ERN1 HEL-S-99n DNAJC3 CEBPZ MBTPS2 AMFR ATF4 EIF2A HEL-S-72p OS9 SYVN1 SEL1L SREBF2 HEL-S-125m DDIT3 BCL2 DNAJA2 TRAF2 PMC4325158__F3 Transcriptomic changes in central metabolic pathways induced by pho13Δ during growth on different carbon sources tal-1 HEL-S-49 ENO1 ADH5 PMC6509240__F7 Working model of polyI:C-mediated protection on pancreases from inflammatory injuries CXCL1 IRF3 CXCL2 IL1B PMC11669671__F3 Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products TF SORD MDP1 PMC7465096__F8 “cooperativity model of MIP-1A amplification” in THP-1 monocytic cells TLR4 IRAK1 IRF3 TRAF6 TRAF2 MYD88 PMC10389819__F6 C-Phycocyanin Ameliorates the Senescence of Mesenchymal Stem Cells through ZDHHC5-Mediated Autophagy via PI3K/AKT/mTOR Pathway MSC ZDHHC5 MTOR PMC11669671__F6 BGCs and biosynthetic pathways of (A) amphichopyrone B (39) and (B) penilactone A (41) and B (42) AMPH COCH PMC7550695__F1 Molecular players involved in the NRF1 pathway OGT USP15 NGLY1 NRF1 PMC6854591__F8 PH-EPS modulates the activation of RAW264.7 cells through the TLR4(Dectin-1)/NFKB/MAPK pathway TIRAP TNF MYD88 PMC10531730__F1 Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications RHEB TSC2 TSC1 IGF1 IRS1 PMC5085738__F4 Schematic model of drought responsive proteins involved in photosynthesis, carbon metabolism, fatty acid metabolism, and nitrogen and amino acid metabolism HEL107 RPE AGXT NONO HPR HEL-S-162eP AMT PC CS PMC6755737__F1 The central carbon metabolism of C PTS PMC10741690__F2 Mitophagy pathway PINK1 AMBRA1 BNIP3 FUNDC1 OPTN PMC11844033__F8 Graphical Abstract Under hypoxic conditions, JUN enhances the transcription of EGLN3, which subsequently binds to HUR to positively regulate the stability of EGFR mRNA JUN EGFR EGLN3 PMC5930795__F5 Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity TRH IGF1 FGF21 GHRH ATF4 STATH IRS1 PMC6856370__F9 Model of cross-talk between D2R and Wnt/Beta-catenin pathways, and Wnt3a transcriptional regulation WNT3A APC GSK3B LRP5 LRP6 PMC8708225__F1 Activation of the Hippo Pathway in Rana sylvatica: Yapping Stops in Response to Anoxia LATS1 LATS2 SOX2 PMC7366106__F8 TNF pathway modified from hsa04668 TRADD SELE ITCH MLKL LIF IL6 TRAF3 TNF C2 CASP3 MMP3 TRAF2 FADD PMC9523645__F7 SARS-CoV-2 Nsp6-mediated disruption of glycolysis MAX MGA HEXA TFDP1 GCK MYC PCGF6 PMC5590720__F1 Modes of action of Abatacept/Belatacept and anti-CD28 domain antibodies CD80 APC PMC4950965__F2 Targeting the RB-E2F pathway in breast cancer CDK6 MYC CDK4 PMC3887071__F2 Synthesis and Biological Properties of Fungal Glucosylceramide C6 C7 C9 PMC2680291__F1 Illustration of some of the key enzymes involved in the metabolism of methotrexate (MTX) FH DHFR GGH TYMS SLC19A1 ABCG2 HEL-S-70p FPGS PMC3566151__F1 TGFB and TGFB/Smad Signaling in the Interactions between Echinococcus multilocularis and Its Hosts SMAD2 SMAD4 PMC7116212__F6 Ribosome biogenesis pathway showing genes which are significantly changing upon sodium azide treatment of wild type cells UTP15 BMS1 RAN UTP6 UTP4 TCOF1 IMP3 NMD3 DKC1 IMP4 NHP2 PWP2 NOB1 GAR1 UTP18 NOP10 LSG1 POLI EMG1 NHP2L1 DRG1 NOP58 NOP56 PMC9500434__F8 Fucoxanthin prevents breast cancer metastasis by interrupting circulating tumor cells adhesion and transendothelial migration CDH2 VCAM1 CTNNB1 HEL-S-15 PMC6844627__F4 Mapping Biological Networks from Quantitative Data-Independent Acquisition Mass Spectrometry Proteomic Data: Data to Knowledge Pipelines DUSP3 HEL-S-101 CLIC4 LDB3 UBC HEL113 HSPD1 ENO3 HEL-S-162eP CYCS TNNI3 PMC8908968__F2 Genetics and Epigenetics of Parathyroid Carcinoma WT1 HIC1 CDC73 APC LRP5 LRP6 EZH2 DKK2 AXIN2 CTNNB1 PMC4451040__F2 Back from the dead; the curious tale of the predatory cyanobacterium Vampirovibrio chlorellavorus C6 IPP APC CS AEN PMC4023818__F10 Working model RPS6 TSC2 TSC1 PER1 PMC7357070__F3 Toll-like receptor signaling pathway includes the highest number of the proteins identified, related to immune system pathways and appearing in both SARS-CoV-2 and HIV-1 infections TIRAP CTSK TLR9 CD14 CPO RAC1 LBP IRAK4 FADD PMC12076214__F3 Multifunctional cytochrome P450 orchestrates radical cleavage and non-radical cyclization in 5-oxaindolizidine biosynthesis† C2 SP3 SP2 PMC8115730__F2 Mechanisms controlling pancreatic islet cell function in insulin secretion ACLY CIC SENP1 PC HEL-S-26 HEL-75 PMC3262193__F3 Signaling pathways and proteins that increase or decrease STAT5 signaling in normal mammary epithelial cells EGF TGFA ERBB4 PAK1 PRL ELF5 PMC10706414__F1 Interleukin (IL)-37 maintains its anti-inflammatory outcomes by limiting IL-18RA from adhering to IL-18 and by attracting the orphan decoy IL-1R8 to the IL-18R/IL-37/IL-1R8 complex STAT3 FYN NLRP3 PTEN MTOR MYD88 PMC7817290__F1 The effects of hypoxia on BMSC senescence MIF MTOR PMC8614808__F4 TRAP1 in Oxidative Stress and Neurodegeneration CDH2 STAT3 ELF2 ATF4 EIF2A PMC8505617__F6 The TGFB signaling pathway and the interaction between lncRNAs and the pathway TF TGFBR2 SMAD2 SMAD4 TGFBR1 PMC8505617__F5 The Hedgehog signaling pathway and the interactions between lncRNAs and the pathway GPR161 SUFU PTCH1 SMO PMC3995050__F1 The PI3K/Akt/mTOR pathway RHEB TSC2 BAD RICTOR TSC1 PTEN MDM2 PDK2 MTOR PMC8326207__SF2 Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions CERS3 TG EPHX3 WAS SDR9C7 CYP4F22 PMC8505641__F4 Mechanisms involved in the modulation of inflammation by miRNA derived EVs STAT3 NLRP3 IRAK1 PTEN SRC IRAK4 MYD88 PMC4943346__F1 Destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma APC CTNNB1 PMC5655313__F4 Role of growth differentiation factor 11 in development, physiology and disease FSTL3 GDF11 WFIKKN1 PMC8218521__F1 Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy CD80 GAL MUC1 CD19 PMC8218521__F2 Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy GMPPB NANP FUT8 GFPT1 NAGK DPM3 MAN2A1 MGAT5 MGAT1 SLC35A2 MGAT2 GCK GAL DPM2 SLC35B4 HK2 SLC5A1 TSPAN31 GMDS ALG3 CMAS C18orf45 FCSK PMM1 SLC35A1 SLC35A3 GNE PGM3 UGDH ALG13 DPM1 PMC9169372__F7 Targeting type IG phosphatidylinositol phosphate kinase overcomes oxaliplatin resistance in colorectal cancer RAD50 MRE11A BRCA1 PMC6397541__F7 AhR−AREG axis defines a signaling pathway between cellular intrinsic redox mechanisms and surrounding TME CXCL5 EGFR CXCL1 AHR CXCL2 CCL5 AREG VEGFA CCL2 PMC8699227__F7 Cell Cycle Progression by Growth Factor-Induced Cell Signaling PTEN CDK4 PMC8699227__F8 Cell Cycle Progression by Growth Factor-Induced Cell Signaling BAD PTEN PMC11659109__F3 Triggers for postnatal metabolic shift UCP2 GLA HIF1A PMC4357026__F8 Diagram depicting the possible activation of TM detoxification of xenobiotics TLR4 CD14 ABCB1 PMC3762301__F3 Molecular inhibitory mechanism of cPAP to block proliferation and survival of prostate cells RAF1 ERBB2 H1-2 PMC3739039__F3 Integrated “omic” analysis reveals global metabolic changes HEL107 UMPS HEL-S-70p PMC12205135__F3 Molecular mechanisms of peripheral sensitization in cancer pain BDKRB1 TRPV1 CCL2 BDKRB2 PMC12205135__F5 Glia-neuron interplay drives central sensitization in cancer pain CXCL12 CXCL1 IL8RB CXCR4 PMC9490723__F1 Proviral role of caspase-6 MAVS IRF3 IRF7 ATF4 EIF2A PMC6335100__F2 Mechanistic target of rapamycin (mTOR) signaling network RHEB NF1 ULK1 TFEB PTEN ATF4 GRB2 CASTOR1 IRS1 SLC38A9 PMC4636073__F7 T cell receptor signaling pathway showing downstream mediators regulated by DNA methylation, gene/protein expression and/or protein phosphorylation GRAP2 CD3D ZAP70 RAF1 PDCD1 SOS1 CARD11 GSK3B MAPK9 MAPK3 IFNG MAP3K8 PTPRO FYN BCL10 PDPK1 NRAS ITK MAPK1 NCK1 VAV1 CTLA4 FOS HRAS ICOS PAK1 MAP3K7 GRB2 CDC42 LAT NCK2 MAP3K14 IKBKG PLCG1 NFKBIE CHUK IL2 CDK4 IL10 JUN LCP2 IL4 NFATC1 ARHA IL5 KRAS CBL NFKB1 IKBKB RELA NFKBIA MAP2K1 MAP2K2 CD3G NFKBIB CD3E LCK PMC5216784__F10 Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1A and PERK pathways ATF4 XBP1 PMC8262610__F2 Fc Gamma Receptors as Regulators of Bone Destruction in Inflammatory Arthritis TEC SYK BTK OSCAR NFATC1 TRAF6 PMC5334358__F1 Necrototic pathway SAP130 HMGB1 TRADD TRAF5 S100A9 CYLD TRAF2 FADD PMC9277014__F1 Roles of TNF Signaling Pathways in Metabolism of Bone Tumors TRADD TRAF2 FADD PMC5343756__F1 A Critical Evaluation of Neuroprotective and Neurodegenerative MicroRNAs in Alzheimer’s Disease RAN AGO2 DROSHA PMC6770144__F1 HER2 signaling pathway JUN CDK6 CCNE1 CDK2 PTEN MDM2 MTOR MYC CCND1 FOS CDK4 PMC6770144__F2 Mechanism of TRA/GO action TRADD MLKL TRAF5 TRAF2 FADD PMC8002821__F3 Classical NFKB (Right) and STAT3 (left) activation pathways STAT3 HGF RELA TRAF3 MTOR TRAF2 UNK PMC12089637__F7 Proposed mechanism of LRRC56 regulation BC progression via RhoA/ROCKs axis ARHA LRRC56 YAP1 HEL-S-15 PMC7792434__F1 IL-39 and signaling pathway STAT3 STAT1 EBI3 IL23R PMC3579806__F4 Differentially Expressed miRNAs after GnRH Treatment and Their Potential Roles in FSH Regulation in Porcine Anterior Pituitary Cell CDC42 TF EGF MMP14 GNRHR EGFR MMP2 GRB2 SRC FSHB PMC6125400__F4 Simplified KEGG pathway “Proteoglycans in Cancer” with H3K4me3 and H3K27me3 enriched genes MAPK4 ARHGEF12 MAP4 PLAUR ARHA MYC PS1TP5BP1 PMC9166240__F6 Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy STAT3 ZAP70 MMP12 LRRK2 SMAD4 MTOR ARHA RUNX2 CD47 DOK1 IGF1 TLR7 GAB2 PMC11745089__F2 Relationships between gut microbiota, gut microbiota-associated metabolites, and EGFR/VEGFR/KRAS pathways EGF SP1 EGFR NRP1 MTOR PMC9166240__F8 Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy STAT3 MYD88 PMC9011113__F3 Myth of cobra venom cytotoxin: More than just direct cytolytic actions HSP90AB1 ENG FAS CASP3 ATF2 NOX4 PMC2707240__F2 Proposed model for As2O3-dependent activation of the mTOR pathway in a negative feedback regulatory manner in malignant cells RPS6 EIF4B MTOR EIF4E PMC3466441__F1 Peptide neuromodulation in invertebrate model systems PDF EN2 EN1 PMC6244318__F1 KEGG insulin signaling pathway identified by WebGestalt from the bta-miR-486 target gene list TSC2 BAD FAS INSR FOXO1 GRB2 INS EIF4E PMC6617290__F1 Model that proposes the form in which physical activity activates the nuclear factor erythroid 2-related factor 2 (Nrf2)–Keap1 pathway KEAP1 MAF PMC7140412__F2 The autophagy molecular pathway and target steps of its modulation RHEB ATG3 ATG12 FOXO1 UVRAG AMBRA1 ATG14 MTOR ULK2 PMC6617290__F2 Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise EEF2K TSC2 IGF1 USF1 MTOR NRF1 SIRT1 PMC4111995__F2 Molecular insights into NF2/Merlin tumor suppressor function LATS1 LATS2 AMOT PALS1 PMC8115215__F8 PSA regulatory mechanism of VRC metabolism CYP2C19 TRAF6 IL1B MYD88 PMC4356644__F1 BiP and its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions SIL1 SEL1L PMC5732750__F6 CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer CXXC4 SP1 GDF15 PMC2953915__F7 Model of E2F2-mediated regulation of the Ahr pathway E2F2 AIP AHR AHRR FAN1 PMC8505617__F1 The canonical Wnt/Beta-catenin signaling pathway and the interactions between lncRNAs and the pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC2667932__F1 Model for TGFB1-induced PAI-1 expression EGFR SMAD2 SMAD4 RHO PMC9456094__F2 PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review TGFBI APOE PMC6313860__F2 CLV-WUS signaling pathways in model and crop plant meristems SI FOS PMC3794713__F1 Simplified overview of commonly mutated oncogenes, tumor suppressors, and pathways in endocrine cancer MAX TMEM127 NF1 BRAF MYC RET VHL PMC5217521__F2 Oncogenic mutations for the upregulation of EREG expression.Notes: Oncogenic mutations in the EGFR, KRAS, or BRAF genes result in activation of the MEK/ERK signaling pathway, which in turn upregulates EREG expression EREG ERBB4 BRAF KRAS PMC6812587__F2 Macrophage function by polyamine synthesis NOS2 SMS SRM SMOX ARG1 ATG5 ARG2 PMC6755139__F3 STRING connectivity network demonstrating a protein–protein interaction network of predicted functional partners for differentially expressed genes in the brown module CDC42 GABARAP RGCC RIOK3 RPL30 RILP DNAJB2 DNA2 UQCRB MAF IGF2BP2 ABCG2 OPTN HEL-S-134P TFR2 DPM2 SNCA CMAS FECH TESC EPB42 DCAF12 RPIA USP12 TPGS2 NUDT4 TRAK2 DPH3 SNX1 ZMAT2 KAT8 SERF2 HAGH TXNRD2 RPL26 PMC4853920__F3 Alternative pathway is constitutively active at low levels through the hydrolysis of the thioester in C3 to C3(H2O) C6 FH HEL-S-62p PMC4703717__F1 Synthesis and immunomodulatory effect of gangliosides CD40 CD80 GAL ST8SIA1 PMC1237076__F7 Wnt-NLK pathway inhibits the activity of Myb family of proteins by two different mechanisms MAP3K7IP1 HIPK2 WNT1 NLK PMC10946266__F6 MgH2 protects against APAP-AKI by inhibiting TXNIP/NLRP3/NFKB pathway BAX BAD NLRP3 PMC2699768__F3 Aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism LTBP1 SP1 PLG AHR PMC5359838__F5 Schematic representation of the opposite p53-TRIM8 and N-MYC-miR17-5p/miR106b-5p networks in cellular response to treatments TRIM8 PMC2699768__F1 Aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism EGFR GSK3B CTNNB1 PMC6888570__F2 Canonical KEAP1/NFE2L2 antioxidant signalling pathway, induced by electrophilic ligands RBX1 KEAP1 NFE2L2 PMC4584279__F3 Selected signal networks induced by Dectin-1 and Dectin-2 SYK RAF1 BCL10 PLCG2 COX2 RELB PC HEL-S-11 GRB2 EGR2 CCL20 CARD9 PMC4317086__F1 Figure can be read from the upper-left corner in an anti-clockwise direction HEL-S-2a RHAG PMC2677203__F7 Signaling via the TgfB type I receptor Alk5 in heart development DKFZp781O1323 SMAD2 AK3 NFATC1 ARHA RUNX2 CTNNB1 PMC10970480__F3 Potential mechanisms by which exercise intervenes in insulin resistance through mitochondria-associated membranes TG FIS1 MFN2 MCU FUNDC1 PMC7340521__F7 Dual RNA-seq provides novel insight into the roles of dksA from Pseudomonas plecoglossicida in pathogen-host interactions with large yellow croakers (Larimichthys crocea) IL15 MMP14 LTA FAS CSF1 TRADD TNFAIP3 ITCH MLKL CXCL1 TAB3 SOCS3 TRAF3 CXCL3 CX3CL1 NOD2 MMP3 CSF2 CASP8 IL18R1 SELE LIF CXCL2 MMP9 IL6 TNF CXCL10 MAP3K7IP1 EDN1 TRAF1 CASP10 TRAF2 FADD PMC10970480__F2 Lipid metabolism-related proteins and pathways involving mitochondria-associated membranes CYB5R3 TG PSD DGAT2 SCD CYP11A1 PBR PMC3794713__F2 mTOR and MAPK pathways RHEB TSC2 TSC1 PTEN GRB2 PMC5922385__F8 Model of miR-652-mediated mechanism of EMT in PC3 cells PMC8829035__F9 Trilobatin, a Natural Food Additive, Exerts Anti-Type 2 Diabetes Effect Mediated by Nrf2/ARE and IRS-1/GLUT2 Signaling Pathways KEAP1 NQO1 PIR INS PMC5859169__F4 Alzheimer’s disease pathway and enriched gene ontology with Down-regulated genes NAPA CDC42 VDAC3 COX7B NDUFB6 NDUFB5 DCTN4 COX7A1 SLC17A7 SLC17A8 PPP3R1 NDUFV2 CYCS POLR2K NDUFA7 MAPK9 DNM3 PPP3CA MTOR SYT10 NDUFAB1 UNC13A NDUFS3 COXFA4 SLC25A4 MAP2K4 HEL-S-44 MAPK1 UBE2G1 SNCA NAE1 GNAL RAC1 RTN3 CALM1 SNAP25 SYT1 PMC3871865__F1 Photoreceptor cell death and rescue in retinal detachment and degenerations CASP9 CASP8 NLRP3 CASP3 IL18 FADD PMC8274179__F1 Cell death as part of innate immunity: Cause or consequence? RIPK3 BAX IL18 MPO PMC3760899__F3 Comparative Transcriptome Profiling of an SV40-Transformed Human Fibroblast (MRC5CVI) and Its Untransformed Counterpart (MRC-5) in Response to UVB Irradiation BAX GC20 NAT14 BCL2L2 TSPYL5 CDKN1A MEN1 SPHK1 AREG GADD45A PMC9615247__F1 STAT3 in the pathogenesis of nasopharyngeal carcinoma and its significance in anticancer therapy SOCS1 STAT3 EGF HGF TGFA MCL1 IRF4 CCL5 TNF CXCL10 MMP2 AHR IL23R IL9 CCL1 PMC5316362__F2 Ingenuity®Pathway Analysis (IPA®) revealed significant overlap between the XDP signature and gene networks related to (A) RNA polymerase II (p = 1.19 × 10−6) and (B) NFKB (p = 1.36 × 10−12) ANGPT1 HOXA10 HOXA11 MAP2K1 MAP2 PMC7817929__F3 Molecular Features of the Serrated Pathway to Colorectal Cancer: Current Knowledge and Future Directions MCC RNF43 BRAF ZNRF3 HP KRAS AXIN2 MGMT PMC4150760__F3 Inferred non-small cell lung cancer pathway using the SpliceNet and RNASeqNet EGF BAD TGFA EGFR BRAF ERBB2 GRB2 PMC4246201__F10 Relationship between GPxs and the NFKB pathway in the antiproliferation action of butyrate GPX4 VCAM1 GPX3 PMC6610297__F7 Metabolic pathway of glycerophospholipid, glycolysis, and TCA cycle under hypoxia stress LPA PGP FAS CDS1 PC HEL-S-26 PMC4824143__F1 Smad and non-Smad transforming growth factorB1 (TGFB1) signaling pathways MAP3K7IP1 TGFB1 SMAD2 SMAD4 ATF2 PMC3464294__F4 Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells SMAD2 VTN MTOR FRAT1 PLAT MDM2 MMP7 LIMK2 LIMK1 PLAUR LRP5 PLG HEL-S-28 VAV1 VEGFA ARHA SHE RAC1 DOCK1 EIF4E HRAS CRK MAP3K7IP1 PAK1 NLK GRB2 WIF1 NCL PMC6458850__F6 The role of CXXC5 and molecular mechanism of KY19382 in longitudinal bone growth CXXC5 GSK3B CTNNB1 PMC2673912__F6 Activin Modulates the Transcriptional Response of LBT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation CDC2 RAD50 TCP1 CDC20 APC ORC1L VEGFA PLK1 FANCG GTSE1 BRCA1 CDR2 RELA CDK2 ATM MDM2 GADD45A PMC2673912__F8 Activin Modulates the Transcriptional Response of LBT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation NR1i1 MAX CEBPA EGR1 SP1 EBP CREB1 CTNNB1 PMC11396801__F1 Selection of Reference Genes in Siraitia siamensis and Expression Patterns of Genes Involved in Mogrosides Biosynthesis MVD GLA MVK PMC8911477__F3 Dysregulation of mTOR Signaling after Brain Ischemia RHEB TSC2 TSC1 IGF1 BDNF PMC6255979__F2 Non-canonical mechanisms whereby betaine inhibits IL-1B production NLRP3 IL1B CARD9 FADD PMC4248710__F13 KLF4-dependent miRs cooperatively promote RAS-ERK pathway activity by cotargeting of pathway inhibitors SPRED1 NF1 GRB2 SPRY1 PMC4037835__F1 The MDC–MMSET–UBC9–53BP1–BRCA1 pathway BRCA1 PIAS1 MDC1 PMC8699127__F4 Tissue-Nonspecific Alkaline Phosphatase, a Possible Mediator of Cell Maturation: Towards a New Paradigm SMAD1 APC BMP2 LRP5 SMAD4 LRP6 CTNNB1 PMC6615683__F6 Model describing the putative mechanism of synergetic interaction between PFK158 and erlotinib in WT and mutEGFR NSCLC cell lines EGFR CREB1 PMC5900789__F1 IL-10-mediated modulation of myeloid cells TF STAT3 CD80 CD14 IRF3 IL10RA SOCS3 NFIL3 MYD88 STAT1 HLA-G TLR4 GPNMB JAK1 TYK2 PMC6178360__F5 Metastatic adrenocortical carcinoma STAT3 ERBB4 NCOA1 NCOR2 NR1B3 ADCY9 ADCY3 NCOR1 RBP3 STOM CREBBP ATM EP300 EIF2AK2 PMC10930675__F8 RUNX2 and CXCR4 effects on melanoma cells MTOR CXCR4 RUNX2 PMC8579759__F4 Oh, the Mutations You’ll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma SMAD2 SMAD4 PMC11656958__F7 Schematic diagram depicting that STING exerts antiviral innate immune response by activating pentose phosphate pathway HEL107 UBE3A TBK1 CGAS IRF3 PMC6071809__F6 Proposed signaling pathways implicated in the promoter-specific expression of CYP19 in Hs578t cells MAPK1 STAT3 MAPK3 PMC7779984__F2 Omega 3 Fatty Acids and COVID-19: A Comprehensive Review MAP3K7IP1 TLR4 TRAF6 MYD88 PMC7033213__F3 Top causal network explaining observed gene expression differences TXN CASP8 HEL-S-162eP EGFR NFKBIA CASP3 HIF1A PARP1 PMC5989395__F2 Working model of the role of lysophosphatidic acid (LPA) at the maternal-conceptus interface in pigs LPA ENPP2 PTGS2 LPAR3 PMC4521627__F3 Integrating physiological regulation with stem cell and tissue homeostasis BMI1 PRDM16 PTEN VHL PMC6003554__F2 Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population ATR CHEK2 ATM PMC5630004__F2 Drug targets on the TGFB signaling pathway TF SMAD4 PMC7750395__F9 Graphic abstract of IAV-induced acute lung injury HMGB1 TLR4 MPO PMC5630004__F1 Context-dependent transforming growth factor B (TGFB) signaling outputs arise from pathway interactions TF EGF TGFA SMAD4 TNF PMC3114084__F2 Titin domain arrangement in the cardiac sarcomere and connectivity within a mechanical signaling network NBR1 FHL2 FHL1 PMC8447269__F2 Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia SUFU SMO PMC11984845__F8 Proposed model integrating multi‐omics data of FIIN‐2 highlights the regulatory network of downstream and involved signaling pathways TF STAT3 TSC2 BCL2L1 TSC1 EPHA2 FRS2 EGFR PIP4P2 MTOR PMC7947698__F1 The Wnt signaling pathway in transgenic mice DKK1 APC GSK3B CTNNB1 PMC8447269__F1 Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia ADRBK1 SUFU PTCH1 DHH SHH IHH SMO PMC7178546__F1 Signaling Model from CAR Antigen Binding Through ERK Activation, Incorporating Models from literatureArrows and bars indicate activating and inhibitory interactions, respectively CD37 LAT CSK ITK CD19 GRB2 LCK PMC4426444__F2 Reconstructed metabolic pathways in the common ancestor of apicomplexans and dinoflagellates at the time of plastid gain (A) and in Hematodinium sp IPP FAS FES DAP PMC11629464__F1 MiRNA regulation of apoptosis and autophagy in Mtb-infected macrophage SOCS1 BAX BAD TIRAP CD14 IRAK1 MTOR TNF TRAF6 IRAK4 MYD88 RHEB IFNG STAT1 MAP3K7IP1 FOXO1 FOXO3A TLR4 TFEB BCL6 PMC6691526__F2 Impact of ovarian cancer-exosomes on target cells during pre-metastatic niche formation CD44 STAT3 ATF2 MMP9 CTNNB1 PMC10381003__F2 The TLR signalling pathways with highlighted gene polymorphisms involved in OA susceptibility TLR1 TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 TLR7 TRAF3 TRAF6 MYD88 PMC2677410__F2 Novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell RHEB TSC2 TSC1 PML PTEN MTOR PMC7717626__F1 Identity and the heterogeneity of extracellular vesicles and exosomes CD81 CD9 CD63 PMC10533046__F3 Recent Advances in the Biosynthesis of Natural Sugar Substitutes in Yeast UGT1A1 IPP PMC11012607__F4 Understanding the Impact of Polyunsaturated Fatty Acids on Age-Related Macular Degeneration: A Review ELOVL3 ELOVL2 ELOVL1 ELOVL5 TNF PMC3174190__F2 Autism-Associated Gene Expression in Peripheral Leucocytes Commonly Observed between Subjects with Autism and Healthy Women Having Autistic Children RPL3 EEF1E1 DGKA RPS17 RPL41 SART3 KLRC3 PC4 CNBP MAGOH MAGEA4 PMC10179295__F2 Paxillin participates in Wnt, integrin-FAK, and TGFB signaling pathways TGFBR2 FYN SMAD2 SMAD4 ARHA TGFBR1 PMC10179295__F3 Paxillin participates in MAPK and PI3K/AKT signaling pathways EGFR PTPRT SRC CCND1 PMC6513850__F8 Diagrammatic model summarising the proposed bimodal Wnt signalling regulation by DYRK1A, as reported in Figs – DYRK1A APC PMC8156652__F9 Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles GSK3B PTEN GRB2 PMC3430470__F5 The role of Monosaccharide Transport Proteins in carbohydrate assimilation, distribution, metabolism and homeostasis GAL HEL-S-62p C2 PMC7875919__F2 Lipid metabolism by the unfolded protein response ACLY FAS INS ELOVL4 PCSK9 LPA TG MTTP HMGCR DGAT2 LPIN1 LDLR CPT2 PECR CHKA CHKB PMC9623391__F1 Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease SPR HEL-S-90n KYNU KMO PMC6173648__F6 A hypothetical pathway that may underlie vibration-induced changes in gene transcription in the prostate BARD1 IL16 PMEL PMC6885365__F4 Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis tmp_locus_29 ACADS NANS LMNA PMC3396054__F3 TGFB activates Smad 2/3 and Smad1 pathway SMAD1 SMAD2 CTGF PMC8710701__F8 Neutrophil Homeostasis and Emergency Granulopoiesis: The Example of Systemic Juvenile Idiopathic Arthritis STAT3 STAT1 CEBPA PIM1 CDK2 SOCS3 MMP9 JAK1 CEBPB PMC4722119__F1 Regulation of fatty acid synthase by O-GlcNAcylation, Terra incognita TPR OGT FAS PMC4425321__F1 General scheme, illustrating BDNF-TrkB signaling through three main pathways in the neuronal cell (NC).Notes: PLCG pathway results in activation of neuronal plasticity and long-term memory formation via PKC, TRPC, and transcriptional factor CREB BAX GRB2 MTOR BDNF PMC4425321__F2 Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness CDC42 BDNF TRAF6 PMC9339642__F1 Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers GALNT3 STAT3 TUBA4B EGFR ST6GAL1 APC PTEN MTOR YAP1 IRS1 LATS1 BCL9 FBXW7 HMGA1 FOXO1 GC HOXB13 ZEB2 SIRT1 BRCC3 PMC8178780__F1 Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation STAT3 TLR4 CR2 PMC4269194__F1 Spatiotemporal regulation of feeding response by O-GlcNAcylation OGT GSK3B IRS1 PMC11866848__F6 Research progress of disulfidptosis in the TME KEAP1 SLC7A11 ATF4 PMC11866848__F7 Relationship between disulfidptosis-related pathways and ICIs EGR1 GLS HK2 IRF4 RAC1 PMC11866848__F4 SLC7A11 inhibiting ferroptosis in cancer cells SLC7A1 GPX4 ALOX12 PMC7937699__F2 From Melanoma Development to RNA-Modified Dendritic Cell Vaccines: Highlighting the Lessons From the Past CD80 MTOR PMC7010683__F8 Metformin reduces HGF-induced resistance to alectinib via the inhibition of Gab1 HGF MTOR PMC6023766__F4 Apoptosis signaling pathway and its control by phosphorylation BAX BAD BMF HRK BIK PMC11672879__F3 Protective mechanisms of phytochemicals in AMD BAX GCLM NQO1 GCLC SIRT1 PMC5963348__F7 Schematic model for SIRT3-induced autophagy and its underlying mechanism in SH-SY5Y cells following rotenone treatment SIRT3 ROS1 MTOR PMC9354605__F3 Landscape of chimeric antigen receptor T cell therapy in breast cancer: Perspectives and outlook ICOS CD27 PMC6023766__F2 Control of the PI3K and RAS signaling pathways by phosphatase signaling PTEN GRB2 PDK2 PMC8748692__F9 Proposed model for ER-stress-induced AR decrease ELF2 ATF4 PMC8291901__F2 Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment PGC ABO SIRT1 PMC6015598__F2 Dysfunctional cellular mechanisms in PD VPS35 RAB1A LRRK2 TFEB DNAJC6 SNCA PMC2922045__F1 TLR AGONISTS: Are They Good Adjuvants? TBK1 TIRAP TLR9 CD14 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR7 PMC7320018__F6 Possible roles of TBC1D9 (A) and MFGE8 (B) STAT3 OS9 MFGE8 SEL1L HIF1A TWIST1 PMC5461634__F3 Sub-network of cell cycle pathway regulated by C1orf132 and TMPO-AS1 GADD45G STAG1 SMC3 GSK3B ANAPC2 CCNA2 MYC SKP2 PTTG2 CCNB3 RB1 CDKN2A SMC1B CDK6 CCNE1 E2F4 E2F3 WEE1 CDC26 ESPL1 ANAPC10 WEE2 TFDP1 SMC1A ANAPC1 RAD21 CDKN1A CDC45 CDKN1B MCM3 MCM5 CDK2 CDKN1C MCM6 MCM2 GADD45A CDC25B STAG2 ATR CDC20 PCNA CDC6 SFN CDKN2D CDKN2B E2F5 CCNH CDKN2C CDK7 CCND2 CHEK2 TTK GADD45B CCNB1 CCND1 TFDP2 MAD1L1 CDK4 DBF4 CCND3 E2F2 RBL2 ORC3 ORC2 MAD2L1 RBL1 CCNE2 CHEK1 PMC11467144__F2 WNT signalling pathways in the intestinal crypt and potential therapeutic targets RNF43 APC LRP5 ZNRF3 LRP6 CTNNB1 PMC2885591__F2 With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging RHEB AMPH TSC2 RIN1 MTOR PMC10540641__F9 Schematic representing the manufacturing process of a targeted delivery system CD44 MMP2 PMC6385430__F8 Suppression of WNT2 in signaling pathway BAX GSK3B LRP5 CTNNB1 PMC7341846__F5 Alterations to the kynurenine pathway in RCC TDO2 HEL-S-90n KYAT3 IDO1 KYNU KYAT1 KMO HAAO NAMPT AFMID IDO2 PMC7613831__F4 DMT induces a transcriptomic signature promoting FAO and opposing fibrosis in the renal cortex of ZDF and ZDSD rats ACAN PPARG ACOX1 EHHADH NR1C1 CITED2 PC PMC9339518__F1 NAD+ redox balance, consumption and synthesis NAPRT HEL-S-90n KYNU KMO HAAO NAMPT AFMID PMC5835334__F7 Schematic diagram shows that TM suppressed the secretion of NO, TNFA, and IL-1B by reducing the bioavailability of copper and the activity of its downstream ROS/TRAF6/AKT/NFKB signaling pathway TRAF6 IL1B MYD88 PMC2885591__F1 With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging RHEB MLST8 TSC2 TSC1 DEPTOR IRS1 VHL PMC11467144__F7 Summary Chart KLF4 EGF BMPR1A MMP17 ANGPTL2 IL33 GPR49 PMC11467144__F5 EGF signalling pathways in the intestinal crypt and potential therapeutic targets EGF HBEGF IL33 PMC6751629__F8 The role of Asc1 in translation initiation RPSA ELF2 EIF3A ELF3 PMC9264948__F10 Prostate Apoptosis Response-4 (Par-4): A Novel Target in Pyronaridine-Induced Apoptosis in Glioblastoma (GBM) Cells WT1 FAS SOX2 BCL2 HIF1A RAB8B UACA CTNNB1 FADD PMC3986091__F3 Pathophysiology of Lung Injury Induced by Common Bile Duct Ligation in Mice CYP26B1 APOC2 APOC1 S100A8 CLEC4D HAMP RNF149 IL17A ALOX5AP TNF RHOV CLEC4E CXCL3 F10 LILRB4 SAA2 RAB32 IL8RB MB PLA2G7 PMC6102093__F1 Schematic illustration showing mechanisms of smooth muscle cell (SMC) phenotypic switching CYB5R3 ACTA2 MFN2 NOX4 PMC7845653__F3 Podocyte Notch1 signaling in diabetic nephropathy (DN) ARHA RHO NOTCH1 SIRT6 PMC7533414__F5 GSDMENT switches apoptosis to secondary necrosis/pyroptosis HMGB1 CASP3 DFNA5 PMC7533414__F6 Gasdermins augment the mitochondrial apoptotic pathway GSDMD CASP3 DFNA5 PMC3115901__F4 The core biochemical network of the ceramide/sphingosine-1-phosphate rheostat CERS5 CES1 SPTLC3 GCLC FFAR1 PMC9322892__F2 Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic CRP IL-21 IFNG NLRP1 NLRP3 PER2 IL33 FOXP3 PMC3724896__F4 Differentiated Neuroprogenitor Cells Incubated with Human or Canine Adenovirus, or Lentiviral Vectors Have Distinct Transcriptome Profiles FANCD2 BIRC5 RAD51 ATM HEL-S-11 BLM FAT2 MAD2L1 PMC12106535__F6 The apoptosis-related gene/tumor-associated antigen MUC1 in mesenchymal stem cell-mediated treatment of IBD POR GPX4 TLR4 LPCAT3 MSC MUC1 SLC7A11 PMC3951765__F1 NLRP3 inflammasome activation: CD36 serves double duty CD36 TLR4 TLR5 PMC7506080__F1 Upregulation of AMH production in testicular Sertoli cells SF1 SOX9 SRY AMH GATA4 PMC9636637__F2 Iron metabolism in chronic diseases related to obesity SLC3A2 PDX1 GPX4 RP2 SLC7A11 HFE2 PMC4069163__F6 Correction: De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response ZAP70 CD48 INTU LAT CTLA4 ICOS CBL FYN BCL10 ITK GRB2 LCK CDK4 PMC6950413__F1 Summarized natural and heterologous pathways for beta-carotene production investigated herein IPP PMVK PMC7854849__F1 Model indicating roles for MLH proteins in meiotic recombination MSH4 RAD51 SIX1 DMC1 SIX4 RMI1 PMC6287006__F5 KEGG analysis of hsa-miR-210 target genes MAPK1 EHD3 CSF1 PIK3R5 RAB31 ARF1 KSR1 SMAD6 GIT2 EFNA3 INPP5A SYNGAP1 IP6K3 INHBB KIF5A CYTH1 ACVR1B E2F3 FGFR1 AP2A2 PMC9250975__F2 Ubiquitin Binding Protein 2-Like (UBAP2L): is it so NICE After All? CDH2 CDC2 SP1 SMAD2 UBAP2L PTEN CCNB1 CTNNB1 PMC5457463__F3 Phosphoproteomic analysis of CCL2 treated DCs and confirmation of relevant signaling pathways CDC42 ADD1 GPSM1 FHOD1 PLCG2 ROCK1 CCR2 CRKL IQGAP1 ARHA CCL2 PMC9453003__F1 P38 MAPK Signalling in Testis Development and Male Fertility CYP26B1 SOX9 MAP2K6 SRY FGF9 WNT4 NANOS2 RSPO1 PMC7691587__F3 The mechanisms regulated by CMTMs in Hepatocellular Carcinoma CDH2 STAT3 EGF BAD HGF EGFR MMP9 MYC CMTM7 CMTM8 CMTM3 CMTM5 MMP2 BCL2 CCR4 CMTM6 CMTM2 CDK4 PMC6505517__F4 Interaction mapping of overlapping proteome changes in astrocytes treated with GBM a -stem and b -diff EVs APRT KRT1 FUS KRT10 MYC FLNA HEL-S-99n CDK6 RPS17 RPL10 PAH IGF2BP2 RPSA MAP4 HEL70 LMNB2 PSMC4 RICTOR IKBIP PSAP COX6B1 STRAP PFDN2 HSD17B4 SLC3A2 LMAN1 ARPC4 HEL-S-107 TCP1 CALD1 TGFB1 PDAP1 IMMT ARCN1 EGFR P4HA2 CTNND1 VCP TPM1 HADHB HEL-S-128m HEL-S-2a TPM3 STT3A APP HEL2 CDK4 CFL2 ACTN1 HEL-S-67p PDLIM4 KRAS LRPPRC RPL13A NFE2L2 SKP1 ERBB2 RPS25 PMC7890213__F2 Nrf 2 pathway as a target in different neurodegenerative diseases GSK3B IL7R HTT PMC3233287__F2 Illustration of main mechanisms of trastuzumab resistance (in red) and targeted agents to circumvent resistance (in blue) PIK3CA TSC2 TSC1 PTEN IGF1R GRB2 PMC4936551__F1 Proposed scheme to describe how are interconnected with Ca2+-pH signaling components in polar growing cells TH AGPS FER PMC5739026__F1 Three main classes of regulatory small RNAs AGO1 AGO2 DICER1 DROSHA PMC7890213__F1 Physiology of Nrf2 activation in both normal and stress conditions KEAP1 MAF PMC7785591__F1 Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway LRP5 LRP6 CTNNB1 HEL-S-44 PMC9588473__F4 High DKK3 expression related to immunosuppression was associated with poor prognosis in glioblastoma: machine learning approach DKK3 DKK2 SFRP1 PMC9588473__F5 High DKK3 expression related to immunosuppression was associated with poor prognosis in glioblastoma: machine learning approach DVL1 DKK3 THY1 DKK1 GSK3B AXIN1 DKK2 SFRP1 WIF1 CTNNB1 PMC9648670__F1 Interaction between gut microbiota and immune checkpoint inhibitor-related colitis CRP VIT IL1B PMC3243091__F2 Molecular control of palatal shelf growth and patterning BMPR1A OSR2 SHOX2 MEOX2 MN1 FGF10 BARX1 EPHB2 EFNB1 FGF7 MSX1 BMP4 SHH OSR1 PMC8698632__F3 Association of Circulating Heme Oxygenase-1, Lipid Profile and Coronary Disease Phenotype in Patients with Chronic Coronary Syndrome PCSK9 APOB PMC7589579__F2 Schematic representation of the endogenous and microbiota-associated pathways engaged in tryptophan breakdown in the gut environment IDO1 AHR PMC7335670__F7 IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer IQGAP1 CTNNB1 PMC3442575__F4 Genes Involved in the Calvin Cycle and Photorespiration.(A) Schematic of the Calvin cycle and photorespiration pathway in C GCSH HEL-S-68p SHMT1 TAL2 CS HEL-S-51e PMC11126959__F2 Biosynthesis of O-GlcNAc OGA TH GNPNAT1 PGM3 GFPT1 NAGK AMDHD2 PMC11126959__F3 Autophagy pathway CAMKK2 ATG16L1 ATG12 ULK1 SNAP29 MTOR ATG5 PMC11126959__F4 Impact of sustained changes in cardiac O-GlcNAcylation OGA RYR2 OGT REST SP1 ATF4 MTOR XBP1 PMC12178005__F4 Signaling pathways of diverse types of collagen affecting tumor progression by regulating tumor immunity TFAM STAT1 DDR1 SOX9 CXCL5 COL3A1 LAIR2 LAIR1 PMC12178005__F5 Signal ways of diverse types of HA affecting tumor progression by regulating tumor immunity CD44 CTNNB1 PMC7186400__F5 Paraburkholderia sp C6 HEL-75 PMC12178005__F3 ECM remodeling facilitates the formation of immunosuppressive TME CXCL12 DDR1 COX2 TLR4 SPARC CCR7 DDR2 CXCR4 PMC7313051__F2 Graphical summary of biological factors influencing anti-tumor immune response constituting three categories depending on anatomical level: tumor cell, tumor microenvironment, and the whole body IFNG PTEN B2M JAK1 CTNNB1 PMC9671658__F8 Glis1 and oxaloacetate in nucleus pulposus stromal cell somatic reprogramming and survival HEL107 DLAT HEL-S-162eP PC PAH HEL-S-30 PMC6160959__F5 Orlistat from PxEA perspective LPL ARRB2 MAPK13 FASN MGLL LIPF PNLIP PSEN2 ADAM10 GRB2 HEL2 NOTCH1 YWHAZ PMC9559691__F6 Metabolomic Analysis of the Takifugu Obscurus Gill under Acute Hypoxic Stress SLC3A2 GSK3B LRP5 TTI1 LRP6 PTEN FLCN MTOR INS SKP2 DEPTOR IRS1 RHEB RICTOR GRB10 TBC1D7 GRB2 RNF152 SLC38A9 PMC4398932__F5 Putative KF inhibition pathway in macrophage-mediated inflammatory signaling events SYK TLR4 IRAK1 SRC IRAK4 MYD88 PMC6698745__F2 Translesion synthesis RAD18 REV1 PCNA SPRTN POLK USP1 POLI POLE PMC5471801__F3 Enzymes involved in the metabolic pathway of PEB regimen UGT1A1 HEL-S-22 ABCB1 PMC9559691__F5 Metabolomic Analysis of the Takifugu Obscurus Gill under Acute Hypoxic Stress STAT3 INSR SMAD4 CDK2 PTEN MDM2 GRB2 NLK PDK2 SKP2 INS PMC7522758__F1 Circadian Dysregulation of the TGFB/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells TF CRY1 SMAD4 IMPACT PMC10610897__F7 Interaction network of genes and co-expressed lncRNAs involved in IAV replication regulation in MDCK cells HAX1 STAT1 HCLS1 IRF9 RSAD2 JAK1 TYK2 CLDN1 PMC8026947__F3 Unfolded Protein Response Pathway PDIA5 HEL-S-269 ATF4 EIF2A XBP1 PMC5363412__F1 Top Network Associated with the DERs Selected by the Criteria of 4-fold Change in Whole BloodThe functions related to this network are defined as cancer, organismal injury and abnormalities, and reproductive system disease GRHL3 NR1C1 PKD1 CCNO CCNE1 E2F2 E2F3 SMAD2 BCL2 MYC CCND1 TWEAK PMC6473842__F2 Signaling pathways in mDA neuron development PBX1 LRP5 LRP6 CTNNB1 FGFR2 DKK3 FZD3 PTCH2 LMX1A PTCH1 NOG FGFR1 PITX3 ETV4 SHH ZNRF3 WNT1 FGFR3 SMO BDNF GPR49 GLI3 PMC6491942__F10 Schematic depicting the sensitization mechanism of CsA to crizotinib STAT3 BTK KSR2 TLR9 NFATC1 PMC8569340__F3 Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy IFNG BRD4 EGF EGFR BRAF IRF1 PTEN MTOR PMC2662467__F6 Cell proliferation and apoptosis RB1 MDM4 CDK6 NF1 EGFR PDGFRA ERBB2 PTEN MDM2 CDK4 PMC8569340__F1 Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy CIP2A KRAS PMC8569340__F2 Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy PDPK1 KRAS CTNNB1 PMC9637915__F6 Proteomics unveil a central role for peroxisomes in butyrate assimilation of the heterotrophic Chlorophyte alga Polytomella sp. ACLY PXN PDC PMC11234216__F3 Signal mapping of transcription factors regulating the fate of HPCs NR2A1 SOX9 CTNNB1 PMC8532163__F9 Buddleoside-Rich Chrysanthemum indicum L. Extract has a Beneficial Effect on Metabolic Hypertensive Rats by Inhibiting the Enteric-Origin LPS/TLR4 Pathway TLR4 CD14 LBP MYD88 PMC5705877__F1 Biosynthesis of ceramide, sphingosine-1-phosphate, and ceramide-1-phosphate (a) CERK SMS SPHK2 tmp_locus_29 SPHK1 PMC9295051__F3 High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential SP1 HMGA1 SOX9 INSR COX2 AXIN1 CCND1 TRIM65 CTNNB1 PMC9295051__F4 High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential STAT3 BAX HMGA1 EZH2 NOTCH1 PMC11525935__F7 MiR-126 can inhibit the PI3K signaling pathway, promote M1 macrophage polarization, and suppress the activation of FAK and Rac-1, thus accelerating the progression of UUO MMP9 CD163 IRS1 PMC6446709__F1 Pathways for glycerolipid synthesis LPA PC PMC5550862__F8 Role of SDC-4 in the regulation of the integrin and FGF signaling pathways C2 CDK2 CCND1 PMC12203119__F2 Intestinal immunity and microbiota in gut health TLR3 TLR4 TLR9 TLR7 PMC3949025__F11 Scheme depicting the inhibition of smooth muscle contraction via CB1 receptors RGS4 ARHA RHO PMC3601265__F2 Hypothetical pathways involved in MHC–self peptide-TCR recognition and PNH clone dominance IL15 TH IL10 IL2 IL7 TNF PMC9654040__F2 Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in Cancers CIP2A EGFR APC GC GSK3B SRC CTNNB1 PMC6324070__F3 The MAPK (ERK) signaling pathway in the KEGG pathway map (hsa04010) where the main path from growth factor to ERK kinase is marked in pink EGF NF1 EGFR FAF1 KIT GRB2 KITLG DAO CCND1 PMC10453554__F1 Cyclin K-CDK12/13 complexes affect important biological processes and contribute to cancer development by phosphorylating different targets CDK12 BRCA1 PMC7425174__F2 PD-1-mediated immune regulation CD80 APC PMC3656449__F6 The pathway triggered by Tat and leading to activation of ISGs by Tat in APCs infected by HIV STAT1 IFI44 APOBEC3A IRF3 IRF7 OAS1 OAS2 PMC9424577__F6 An immunogenic cell injury module for the single-cell multiplexed activity metabolomics platform to identify promising anti-cancer natural products RIPK3 HMGB1 MLKL TLR4 APC ATM RIPK1 EIF2A APAF1 PMC5347023__F6 High-Concentrate Diet Induced Milk Fat Decline via Glucagon-Mediated Activation of AMP-Activated Protein Kinase in Dairy Cows TG FAS NR1C1 PMC5451860__F1 Role of WNT/beta-catenin pathway on aerobic glycolysis in gliomas HEL-S-133P LRP5 LRP6 CTNNB1 PMC5451860__F2 Opposing effects of PPAR gamma and canonical WNT/beta-catenin signaling in gliomas HEL-S-133P MYC CTNNB1 PMC9513432__F3 How sphingolipids affect T cells in the resolution of inflammation C2 CERS2 HEL-S-5 CERS6 PMC9513432__F4 How sphingolipids affect T cells in the resolution of inflammation IL10 IL6 FOXP3 MTOR PMC9074815__F4 Neuronal Redevelopment and the Regeneration of Neuromodulatory Axons in the Adult Mammalian Central Nervous System SEMA3A LINGO1 RHO PMC6883319__F3 MetaCore-generated pathway of differentially expressed genes involved in protein kinase A (PKA) signaling BAD APC AKAP8 SMAD4 PDPK1 PHKB HEL159 PDE3A 5HT1A NFKBIA AKAP11 PDE4D AKAP12 CREB1 NFKBIB PMC6883319__F4 MetaCore-generated pathway showing differentially expressed genes involved in sirtuin 6 regulation and function HEL-S-133P CD36 SCD FASN LDHB ACACA RBBP8 HMGCS1 LDLR ATF4 PTH ELOVL6 NRF1 PFKM CPT1A PMC6070710__F8 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response GMNN UBC MCM10 ORC3 POLE PMC11495891__F9 Application of EVs in the digestive system CAST FAS MB PMC9218731__F1 Cardiomyocyte death in sepsis: Mechanisms and regulation RIPK3 PANX1 GSDMD NLRP3 MLKL GPX4 TLR4 RIPK1 MCU SIRT1 PMC11495891__F6 Application of EVs in circulatory system injury CAD MSC SIRPA CD47 PMC7654574__F8 Protein–protein interaction networks of energy metabolism canonical pathways affected by AgNPs/CDDP exposure in HepG2 and THLE2 cells ACHE EHHADH HEL60 ACO2 GPX4 KYNU CYCS AFM HEL-S-30 FURIN SDHD ACSL1 ACAT2 HEL-S-49 HEL-S-162eP TXN2 DLD ENO1 PFKL PKLR PMC6883319__F6 MetaCore-generated pathway showing differentially expressed genes involved in mammalian target of rapamycin complex 1 (mTORC1) regulation EGF PLD2 EGFR GSK3B TTI1 AGTR1 PTMS MTOR CS MAP2 TRAF6 DEPTOR RAC1 PDPK1 TLR4 MAPK7 TBC1D7 MAP3K7 GHR PMC7654574__F9 Protein–protein interaction networks of the sirtuin canonical pathway affected by AgNPs/CDDP exposure in HepG2 and THLE2 cells BAX SIRT7 TIMM13 NDUFV2 NAMPT CYC1 MTOR SIRT2 ABCA1 NDUFS3 XPC SIRT3 SDHB APEX1 NFKB1 RELA NDUFB7 APP NDUFB3 ADAM10 TIMM23 TIMM10 GABPA SIRT1 PMC6883319__F7 MetaCore-generated pathway showing differentially expressed genes involved in ATP metabolism PAPSS1 ENPP3 PDE7B PDE10A AK3 BST1 PDE4B PAPSS2 PDE1C AK2 PDE4D ENPP2 FHIT AK5 COASY PMC6883319__F8 MetaCore-generated pathway differentially expressed genes involved in antigen presentation by major histocompatibility complex (MHC) class I: cross-presentation CD40 RAB10 RAB4A ARF6 TLR9 VCP IRAK4 VAMP8 MYD88 SEC22B OLR1 CD74 TLR4 MSR1 TLR7 RAB38 CD209 CLEC9A RAB27A RAB3C CLEC12A RAB33A RAB34 RAB11A HYOU1 TLR3 RAB32 RAB35 EHD1 PMC6883319__F9 Pathway analysis by Ingenuity Pathway Analysis (IPA) IL15 FAS POFUT1 MYC STAU1 CD24 CASP6 PDE3A GGH TNNC2 SLC35D1 RNPEPL1 NEU1 KIF3B PLAGL2 ARFGEF2 ACOT8 TGIF2 ADAT1 PFDN4 NR2A1 PNPLA3 TRIM25 HOXB13 CP PMC5308639__F7 Interleukin-6 increases matrix metalloproteinase-14 (MMP-14) levels via down-regulation of p53 to drive cancer progression STAT3 SP1 MDM2 PMC9141422__F1 Ganglioside GM3 Synthase Deficiency in Mouse Models and Human Patients UGCG ST3GAL5 B4GALT5 B3GALT4 UGT8 PMC3376735__F2 Regulation of the TGFB–BMP receptor complexes by reversible ubiquitylation WWP1 SMURF1 USP15 PMC4010202__F2 Proposed signaling mechanisms underlying the protective effects of mood stabilizing drugs against experimental stroke SP1 MSC BDNF CXCR4 PMC7895883__F1 Negative (blue) or positive (pink) regulation of TET2 in the inflammatory immune responses and related diseases LPL TET2 POLL CXXC5 PDC POLI ARG1 IRF7 SOCS3 FOXP3 PMC4999498__F2 Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells CDC42 SYK BAD PTEN TERT MTOR MEF2C DOCK2 BTK CD74 PLCG2 SP100 DOK3 HDAC2 SIN3A APC BLNK CD19 ARHA CD44 MAGI3 RAP2A APBB1IP LYN GRB2 CXCR4 AKAP12 PMC6070710__F9 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response RB1 ATR CD2 FAS MRE11A CYCS ATM CCNB1 PMC2737513__F1 IMP Dehydrogenase: Structure, Mechanism and Inhibition GMPR ADSL PMC3058380__F5 Focal adhesions in osteoneogenesis FYN MOS GRB2 PMC5354443__F11 Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway CDC2 ATR PMC8377368__F1 Innate Immune System Orchestrates Metabolic Homeostasis and Dysfunction in Visceral Adipose Tissue During Obesity ICOS IL25 FAS APC IL33 FOXP3 RORA GATA3 CD1D PMC4731262__F1 Wnt/Beta-catenin signaling in kidney injury and repair: a double-edged sword CDC42 APC GSK3B LRP5 LRP6 RHO DAAM1 CTNNB1 PMC7762844__F1 mTOR signalling in the cell at a glance RHEB TSC2 TSC1 SGK1 DEPTOR PMC3376735__F1 Logic of TGFB signalling from the membrane to nucleus ATF3 SMAD4 SKI CEBPB PMC5859335__F6 Relationship between cell cycle and common up-regulated genes identified between cancers CDC14B BUB1B STAG1 SMC3 SMAD2 GSK3B SMAD4 ORC1L CCNA2 MYC SKP2 PLK1 PTTG2 RB1 CDKN2A CCNE1 E2F4 MDM2 ESPL1 ANAPC10 WEE2 TFDP1 RAD21 CDKN1A CDC45 MCM3 MCM5 CDK2 MCM6 MCM2 CDC25B TGFB1 PCNA ORC6 SFN CDKN2D CDKN2B CCNH CDKN2C CDK7 YWHAQ TTK ATM CCND1 CDK4 DBF4 CDC2 ORC3 ORC2 RBL1 HDAC1 PKMYT1 FZR1 MAD2L2 PRKDC CHEK1 SKP1 CREBBP PMC6337789__F2 Biological interaction networking of identified HCAECs phosphoproteins in KD CALD1 COPS5 PML TPR UBR5 EMD MYO1C WTAP AKT1S1 POLR2A CAP1 MAPK1 NCK1 PECAM1 HEL114 FZR1 CDKN1A ELAVL1 PAPOLA NELFB HEL-S-102 PRP4K ERCC5 MYBBP1A SRSF4 MCM2 DDX3X NUP98 PMC9270353__F2 Liquid–liquid phase separation in tumor biology FUS RAD50 MRE11A ATM PMC8899988__F12 Novel HDAC11 inhibitor potentiates the tumoricidal effects of cordycepin against malignant peripheral nerve sheath tumor through the Hippo signaling pathway SP1 KIF18A PMC1877048__F1 Nutritional Route Affects ERK Phosphorylation and Cytokine Production in Hepatic Mononuclear Cells TLR4 CD14 PMC9497187__F9 Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells CERS3 CERK ACER1 CERS1 CERS2 SPHK1 DEGS1 DEGS2 SMPD2 CERS6 ASAH2 SMPD4 GLB1 ACER3 PMC5800973__F4 KEY ROLE OF EXTRACELLULAR VESICLES IN THE METASTATIC PROCESS CD44 CD81 FAS MMP9 CXCR4 PMC1783068__F1 Proximal B-cell receptor-mediated signalling pathways BLK SYK BTK FYN BLNK LYN GRB2 BIK PMC8895352__F2 Androgen receptor (AR) signalling pathway associated PC IncRNAs (Adapted from Aird et al. ) STAT3 CTBP1 IL6 PMC8234323__F3 Asparagine: A Metabolite to Be Targeted in Cancers ARF1 ATF4 SLC7A5 ASNS MYC LCK EIF4E PMC9497187__F1 Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells CERS3 CERS5 UGCG CERK CERS1 CERS2 SPHK1 DEGS1 DEGS2 SMPD1 KDSR SMPD2 CERS6 SMPD4 SPHK2 GLB1 PMC6263005__F1 Neuroprotective modulation of the unfolded protein response in Marinesco-Sjögren syndrome: PERK signaling inhibition and beyond ATF4 EIF2A XBP1 PMC10937592__F4 SCFAs bind with FFAR2, FFAR3 and GPR109A to improve hepatic steatosis, respectively FAS FFAR3 FFAR2 PMC10937592__F5 Possible mechanisms of SCFAs-induced epigenetic modifications to improve NAFLD YY1 MTOR MBD2 PMC2633716__F1 Genetic Variation in Calcium Sensing Receptor (CASR) and Risk of Colon Cancer CASR NR1i1 CYP24A1 PMC8348617__F2 Senescence-Associated Glycine max (Gm)NAC Genes: Integration of Natural and Stress-Induced Leaf Senescence MAX SAG NRP1 NRP2 PMC7726811__F1 PIDDosome pathway regulates HCC initiation and expansion PIDD1 CASP2 PMC10937592__F3 Mechanism of SCFAs madiate a decrease in cholesterol levels ABCG5 NPC1L1 CYP7A1 ABCA1 PMC11210699__F2 Therapeutic effects of baicalin and baicalein BAX ULK1 TLR4 CDK2 CCNA2 MTOR CTNNB1 PMC7064791__F1 CXCR3 receptor subtypes and related ligands that eventually result in CXCR3-B anti-tumor mechanisms, and responses in favor of tumor progression in the CXCR3-A signaling pathway following ligation of these ligands CXCL9 CXCL10 SRC PMC4206998__F2 MicroRNA induced by FSH at spermiogenesis IGF1 CCND2 PTEN IGF1R VEGFA FSHR CCND1 PMC11210699__F3 Therapeutic effects of baicalin and baicalein GSDMD NLRP3 BNIP3 BDNF SIRT1 PMC5811474__F6 Pictorial representation of p53 pathway regulated by E3 ligases and DUBs USP42 TRIM13 PHF20 BAX UBE4B CHFR FAS USP11 SP2 TRIM28 RNF43 HIPK2 TRIM25 USP4 ZBTB33 USP2 TOPORS ATM RFWD3 MDM2 USP24 PMC8112354__F1 O-GlcNAcylation in Immune Cell Activation OGA TRAF6 PMC5811474__F4 Illustration of E3 ligases and DUBs that regulate extrinsic pathway of Apoptosis FAS SH3RF2 TRADD ITCH PAK4 TRAF2 FADD PMC5811474__F5 Illustration of E3 ligases and DUBs that regulate TNF induced NFKB pathway SHARPIN ING4 TRADD USP19 PDLIM2 OTULIN TRAF5 USP21 TRAF6 CYLD TRAF2 FADD PMC4467418__F7 miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells AFP PTEN PMC8953107__F5 Fucoidan (Undaria pinnatifida)/Polydopamine Composite-Modified Surface Promotes Osteogenic Potential of Periodontal Ligament Stem Cells BAD CAD LAT OTP PMC7084447__F3 An illustration demonstrating BER OGG1 TDP1 PNKP LIG1 NEIL2 FEN1 PCNA NEIL1 POLE SSB PARP1 PMC8953107__F6 Fucoidan (Undaria pinnatifida)/Polydopamine Composite-Modified Surface Promotes Osteogenic Potential of Periodontal Ligament Stem Cells PI3 PTEN PMC5811474__F3 Regulation of Intrinsic pathway by E3 ligases and DUBs BAX BAD UBR5 TRIM32 RNF7 APC MEI1 TRIM2 PMC2928709__F4 Observation of the differentially expressed genes on the human cell cycle (A) and transforming growth factor beta (TGFB) signaling pathways (B) modified from Kyoto Encyclopedia of Genes and Genomes (KEGG) (www.genome.jp/kegg/kegg1.html) PCNA TFDP3 THBS2 ELL THBS3 SMAD4 PPP2CA NODAL MYC SKP2 CCNH RB1 CDK7 CCNE1 FST NOG CHEK2 WEE1 AMH MDM2 ACVRL1 DCN YWHAG ACVR2B THBS1 ACVR2A SP1 TFDP1 ARHA TNF PITX2 RBL1 PTTG1 RBX1 PRKDC ACVR1 CHEK1 SKP1 CDK2 THBS4 EP300 PMC2902905__F1 Sub-Cellular and Signaling Mechanisms Underlying Polar PIN Localization.A model of regulators and pathways contributing to polar PIN localization in roots is proposed based on results discussed in this review VPS29 SNX1 PIN1 PMC9497674__F9 Gene Expression Profiles of Human Mesenchymal Stromal Cells Derived from Wharton’s Jelly and Amniotic Membrane before and after Osteo-Induction Using NanoString Platform DTX3 DTX4 CIRSR NUMB CCNA2 PSEN1 PSENEN CTBP2 ADAM17 CTBP1 LFNG NOTCH3 DLL3 HDAC2 MAML2 HES1 DLL4 NOTCH2 RBPJ HDAC1 NCOR2 MAML1 FOSL1 PSEN2 EP300 KAT2B PMC11545099__F1 B cell receptor signaling pathway CD79B SYK CD79A BTK BCR PLCG2 CD19 LYN MTOR PMC5523853__F1 Key components of the stress response signaling network in C EGF JUN STK11 SGK1 EGFR SMAD2 HSBP1 PTEN HIF1A IGF1R MTOR SKI RHEB RICTOR PDPK1 GRB2 SIRT1 PMC10590753__F11 Differentially expressed proteins and metabolites KEGG annotation and visual analysis in the purine metabolism pathway OMP APP ADA PMC8234323__F1 Asparagine: A Metabolite to Be Targeted in Cancers ZBTB1 ATF4 ASNS EIF2A PMC8429149__F1 IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore TH MAP3K7IP1 IL36A IL36B TRAF6 MYD88 PMC8436187__F3 Release and activity of SQSTM1 in mouse sepsis GSDMD INSR TLR4 SQSTM1 MITA MYD88 PMC9362849__F5 Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation TRADD ITCH MIB2 RIPK1 TNF CYLD TRAF2 IMPACT PMC4100108__F4 The possible regulatory pathway of melanogesis activation MC1R ASIP DKK1 CTNNB1 PMC3828628__F1 IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK STAT3 SOCS3 IRS1 PMC6722462__F5 Metabolite pathway analysis with Pearson correlation coefficient only edges corresponding to correlations whose similarity was less than 0.5 are shown ACD TNF PMC4434617__F1 Role of transmethylation reactions in alcoholic liver disease VIT HEL-S-61p PMC9362849__F1 Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation SHARPIN TRADD H2AX OTULIN ATM CYLD PMC12185963__F10 TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway TLR3 TAB3 TRAF6 PMC8181875__F4 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer TFAM HMGB1 MAML3 EGFR SIRT4 HEL-S-102 PC SMO HEL-S-303 UHRF1 SIRT1 PMC7680400__F4 Synaptic microRNAs in Alzheimer’s disease NRN1 EPHB2 VAMP2 PTPN1 NRP2 SNAP25 STX1A SYT1 SIRT1 PMC7997823__F1 Signaling pathways of the main cytokines involved in cardiovascular diseases IL1R1 TRADD SHE TRAF2 IL1B PMC8181875__F1 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer STAT3 IL16 CXCL2 PMC8181875__F2 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer STAT3 RAD51 RER1 PC CA9 KRAS PMC8181875__F3 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer CDH2 DKK3 TXNIP HOXA9 WNT7A TP63 PTEN CTNNB1 PMC6748125__F6 Erythropoietin (Epo) binds to the Epo receptor (EpoR) to activate erythroid-specific gene transcription (EpoR, globins, glycophorin A (GPA), and miR-144/451) by GATA-1, resulting in hemoglobin (Hb) production ATG12 EPOR ULK1 SPHK1 EPO MTOR ATG5 PMC8998143__F2 Melanin and Melanin-Functionalized Nanoparticles as Promising Tools in Cancer Research—A Review ASIP PMC4677255__F2 Detected regulatory influences on the canonical Wnt pathway NKD1 LRP4 FRZB TRIB2 TLE3 LRRK2 APC APOE LRP5 LRP6 TCF7L1 DAAM2 TCF19 AXIN2 CTNNB1 EDIL3 TRAF4 SMURF1 NOTUM DKK2 TNIK NARF LEF1 PMC5364150__F7 Shigella modulates the innate immune response in epithelial cells MDM2 TRAF6 TRAF2 PMC3686324__F1 Osteoporosis – a current view of pharmacological prevention and treatment LRP5 LRP6 PTH PMC10861537__F7 Summary: impact of chemotherapy on CAF-S1 and CD8 T cell density in HGSOC ANTXR1 PRF1 FAP YAP1 PMC3686324__F3 Osteoporosis – a current view of pharmacological prevention and treatment LRP5 LRP6 PMC7570440__F1 Major longevity pathways and longevity-associated transcription factors in C TFEB SKP1 MTOR SIRT1 PMC6905468__F8 Schematic summarizing the effect of ATR kinase inhibition in cisplatin-treated quiescent cells ATR ATRIP PCNA PMC5772637__F6 Pathway studio analysis of genes analyzed in the study by the gene array analysis and qPCR BAX CAV2 CASP9 PFKFB4 CASP8 ADM DDIT4 ANXA2 BNIP3 CYC1 ANXA1 MMP9 FOS IKBKG TMED10 COXFA4L3 ANGPTL4 NFKB1 RELA NFKBIA CASP3 NFKBIE BCL2 ACTG2 PMC5772637__F7 Pathway studio analysis of proteins whose genes were analysed in the study by the gene array analysis and qPCR CASP9 PFKFB4 CASP8 TIMP1 ADM DDIT4 MARCKS MMP9 FOS PARP1 IKBKG TMED10 HMOX1 COXFA4L3 TMED1 RELA NFKBIA CASP3 NFKBIE BCL2 ACTG2 PMC5564816__F6 Ring finger protein 125, as a potential highly aggressive and unfavorable prognostic biomarker, promotes the invasion and metastasis of human gallbladder cancers via activating the TGFB1-SMAD3-ID1 signaling pathway CDH2 RNF125 ID1 CTNNB1 PMC6044452__F8 Possible signaling mechanism for cigarette smoke and FGF23-mediated regulation of FGFR4/PLCG/calcineurin/NFAT pathway FGFR4 IL1B FGF23 PMC6877688__F3 KEGG pathway enrichment analysis of photosynthesis related genes in S6, S72, and R (control) groups BOLL PES1 PC PMC7913870__F1 Hippo pathway LATS1 LATS2 STK4 PMC7484659__F3 Schematic model illustrates the neuroprotective effects of THSG on STS-induced toxicity by restoring BNDF-TrkB/Akt signaling axis and inhibiting apoptosis BDNF STS PMC4074185__F3 Hereditary leiomyomatosis and renal cell carcinoma KEAP1 HEL-S-133P PMC7913870__F3 Therapeutic targets to reactivate the Hippo pathway LATS1 LATS2 ALK FRY IKBKE ELL STK4 EZH2 PMC6877688__F4 The endocytosis pathway AMPH CHMP6 VPS25 CAPZB ARF6 LDLR PMC7573881__F5 Network of lncRNAs involved in regulating the Th cell activation pathway in tongue squamous cell carcinoma SOCS1 IFNG CXCR3 STAT3 CCR5 STAT4 SOCS3 GRB2 CD8A GATA3 RUNX3 PMC12120866__F6 Critical gene network analysis of the up-regulated DEGs in the M NDUFB6 NDUFB5 LTA CCL3 CXCL1 ZWINT AHSG UQCRB APOH NDUFB4 GC NDUFB1 UQCRH H3C15 H3C8 NDUFC1 H2AC21 SERPINC1 LIF PLG HRG COX5A CXCL2 HEL-S-78p APOB CENPA CCL4 FGA CXCR4 CCL20 PMC3398046__F5 MicroRNA Profiling in Mucosal Biopsies of Eosinophilic Esophagitis Patients Pre and Post Treatment with Steroids and Relationship with mRNA Targets TNFAIP6 B4GALT1 SAMSN1 LCP2 TP53BP2 RIOK3 ADIPOR1 RNF11 C1R TAB3 MYO6 KRT4 RTP4 TFPI ZFAND5 PMC5290526__F7 A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs CDH2 PMC9293663__F7 Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling MMP3 CXCL10 IL1B PMC3062664__F1 Metabolic insulin signaling pathway genes genotyped in the discovery cohort FRAT1 CBL FYN PTEN IRS1 PMC2790217__F17 Akt regulates growth by phosphorylating and inhibiting the TSC1-TSC2 complex in drosophila TSC2 TSC1 PTEN MTOR PMC5206652__F1 Identification of genetic susceptibility loci for intestinal Behçet’s disease RNASE11 TBCC NAALADL2 CHAC2 POMZP3 SORT1 ERAP1 NENF APP FOS PMC5720977__F1 Wnt and Hippo signaling network that either promotes or inhibits Wnt signaling through cytoplasmic and nuclear interactions of the two pathways LATS1 LATS2 BTRC APC GSK3B TBX5 VGLL4 YAP1 CTNNB1 PMC2349985__F1 Role of Leukotriene B4 Receptors in Rheumatoid Arthritis LTB LTA IL1B PMC3226036__F5 A schematic representation of the two classical apoptotic pathways in mammalian cells FAS DIABLO FADD PMC8778800__F1 FGFR Pathway Inhibition in Gastric Cancer: The Golden Era of an Old Target? PIK3CA FRS2 IL1A GRB2 MTOR PMC9605952__F1 Regulating pathways of ferroptosis SLC3A2 KLF2 DAZAP1 KAT5 KEAP1 RBMS1 GPX4 BAP1 FZD7 SOX2 SLC7A11 CTNNB1 ASAH2 STEAP3 ALOX15 LCN2 SRC PMC9605952__F2 Ubiquitination on ferroptosis CD44 KEAP1 MIB1 USP11 SLC7A11 ABCC5 PMC9605952__F3 Autophagy on ferroptosis GPX4 COPZ1 HIF1A ATG5 PMC10254355__F4 CIN and MSI signaling pathways in colorectal epithelial cancer: A modified cartoon from KEGG depicts known activated pathways in colorectal epithelial cells BAX TBK1 BAD EGFR SMAD2 APC RIOK1 SMAD4 MTOR TGFBR1 CTNNB1 POLK CHUK CCND1 PMC6894087__F7 Schematic drawing that illustrates the signaling pathway involving mTORC1/rpS6/Akt1/2 and Cdc42 utilized by NC1 peptide to induce Sertoli cell BTB remodeling in the testis CDC42 RPS6 PMC4095764__F1 Physiological anticoagulant characteristics of blood vessels on endothelial cells TF TFPI APC PC PMC9402792__F5 MRNA–miRNA–lncRNA Regulatory Network and Factors Associated with Prognosis Prediction of Hepatocellular Carcinoma DUSP10 NR1C1 ISCU RECK EGFR RHOB NOB1 MARCKS JMY HEL70 HEL-S-30 PMC8431530__F3 Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis DHFR HEL-S-61p MTR PMC2553572__F2 DSB repair pathways ERCC1 TDP1 PNKP RAD52 RAD51 BRCA2 ATM PMC6151343__F10 A schematic pathway for rosiglitazone induced HO‐1 expression in HPAEpiCs PAICS TLR4 PMC12245916__F2 Signaling pathways for intestinal microbiota regulating the polarization and activation of intestinal macrophages IRF3 IL6 MYD88 PMC7403206__F3 Podocyte insulin signaling VAMP2 INSR RS1 GRB2 PMC6381368__F6 Schematic representation of the suggested pathway by which CAFs induce cell proliferation, EMT and metastasis in CRC cell MTOR KRAS CCND1 PMC8315016__F8 Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer GSDMD NLRP3 IL1B PMC9144739__F2 Vaccination against Bacterial Infections: Challenges, Progress, and New Approaches with a Focus on Intracellular Bacteria CD40 IFNG NPS BCR PMC6350761__F1 Efforts in redesigning the antileukemic drug 6-thiopurine: decreasing toxic side effects while maintaining efficacy †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00463c TPMT PMC6738830__F6 Proposed model for impaired apoptotic response to hMPV infection in NECs from asthmatics BAX ATF4 EIF2A PMC7445530__F1 Regulatory mechanisms of BLACAT1 on proliferation, invasion, metastasis, tumor cell cycle control, apoptosis, autophagy, and chemoresistance in multiple human cancers CDH2 STAT3 SUZ12 VASP BLACAT1 CCR2 MMP2 EZH2 MMP9 ABCB1 CTNNB1 PMC7457047__F1 Drugs and antibodies that affect the function of the neuromuscular junction ACHE MUSK LRP4 COLQ PMC8526348__F2 Toxic effects of cell-free hemoglobin on the microvascular endothelium: implications for pulmonary and nonpulmonary organ dysfunction TF VWF NLRP3 HEL-S-62p TLR4 CFH IL18 VCAM1 RHO SRC PMC8155534__F6 Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling SMAD2 IL11RA PMC5013148__F9 Positive feedback regulation of type I IFN response mediated by IFNd-induced IRF3 and IRF7 activation in large yellow croaker STAT1 STAT2 IRF3 IRF7 PMC3953130__F2 Ack1 signaling pathway in normal and cancerous cells TMPRSS2 HK2 WWOX PMC11896877__F2 Activation process of nuclear factor kappa B (NFKB) and the regulation of the NFKB signaling pathway by the small ubiquitin-like modifier (SUMO) SENP1 SENP6 ANXA1 SENP2 PMC7555335__F3 Constitutive activation of STAT5 FLT3 EGF TGFA PIM1 EPOR EGFR MTOR PMC8634263__F9 Cyclic Mechanical Strain Regulates Osteoblastic Differentiation of Mesenchymal Stem Cells on TiO2 Nanotubes Through GCN5 and Wnt/Beta-Catenin APC WNT1 RUNX2 WNT10A AXIN2 CTNNB1 PMC8164819__F5 Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance HDAC1 SUZ12 DKK1 APC LRP5 HES1 STRAP CTNNB1 PMC8164819__F6 Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance SMAD1 DKFZp781O1323 FRS2 SMAD2 SMAD4 NODAL FOS TGFBR1 PMC7059188__F2 Soluble factor-activated signaling pathways in fibroblastic cells in CNT-exposed mouse lungs TIMP1 SMAD2 SMAD4 CD63 PMC8202686__F3 A2B Adenosine Receptors and Sphingosine 1-Phosphate Signaling Cross-Talk in Oligodendrogliogenesis RHO RAC1 PMC4643662__F3 The role of S100 proteins and their receptor RAGE in pancreatic cancer S100A4 S100A6 SHH S100A2 PMC7851123__F1 Genetic aberrations in DNA repair pathways: a cornerstone of precision oncology in prostate cancer ERCC1 FANCD2 ATR RAD51 PMS2 ATM PALB2 BLM PMC5872691__F1 One-carbon metabolism and DNA methylation DHFR HEL-S-61p MTR PMC9332234__F1 Concomitant Nrf2 Targeting and Stem Cell Therapy in Cerebrovascular Disease RBX1 KEAP1 PMC9634734__F1 BMP4 in adipose-derived stem cell differentiation: A minireview BAMBI BMPR2 BMP4 PMC2897904__F1 Proposed mechanisms of HDACi-induced apoptosis in colon cancer cells involving the mitochondrial pathway BAX HDAC10 HDAC5 HDAC9 HDAC7 APAF1 HDAC6 PMC7968000__F3 Tumor suppressive role of HNF4A FUS ADAM17 CDKN1A RRM2 BMP7 TCF4 CCND1 SET CTNNB1 PMC4819564__F2 Signaling cascades of Cripto-1, Notch/CSL, and Wnt/Beta-catenin BCL9 EGF PORCN SMAD2 APC CRIPTO SMAD4 NUMB NODAL SRC FURIN CTNNB1 PMC6330122__F3 Neurotoxicity of Anesthetics: Mechanisms and Meaning from Mouse Intervention Studies INSR EGFR GSK3B MTOR PMC7073187__F1 Main mechanisms by which the breakdown of tolerance to food antigens can occur IL25 TSLP IL13 IL33 IL4 IL31 IL5 PMC1797633__F1 Strategies of the different HCV proteins to antagonize IFN therapy STAT1 IFNGR1 TLR3 STAT2 IRF3 EIF2A PMC2724396__F1 Modified Lee-Heinrich model of wnt pathway APC GSK3B CTNNB1 PMC6106831__F5 Granulocyte activation and diapedesis mediators show greater induction during diestrus phase infection than in estrus ICAM2 ITGB1 GLG1 CCR4 IL8RB MIP CXCR4 JAM3 PMC5637726__F1 The role of the TGF-Beta-Smad and BMP-Smad signaling pathways in myocardial infarction and the mechanisms of some associated potential therapies ACTR2 HMGB1 SMAD1 DKFZp781O1323 ID2 SMAD2 TRPV1 SMAD6 SMAD4 GREM2 ABCC6 ID3 PMC5729346__F1 The abnormalities in the pathway of tyrosine metabolism in tyrosinemia type I HPD PAH PMC8151573__F1 Oncogenesis, Microenvironment Modulation and Clinical Potentiality of FAP in Glioblastoma: Lessons Learned from Other Solid Tumors STAT3 TGFB1 SHH PTEN FAP CCL2 PMC6477778__F1 Proposed sources of NOD1 activation and corresponding physiologic, endocrine, and cell tissue communication events leading to insulin resistance in different tissues RIPK2 PC NOD1 PMC6168336__F6 In this illustration, potential mechanisms of tumor cell survival via crosstalk between components of the MET pathway, glycolysis, and autophagy are depicted ATG3 HGF AXL MTOR PMC8307280__F2 Harnessing Carcinoma Cell Plasticity Mediated by TGFB Signaling SMAD2 SMAD4 PMC3835370__F1 Genomic Characterization of the Inherited Bone Marrow Failure Syndromes BRIP1 BRCA1 USP1 BRCA2 PALB2 UBE2T PMC7494613__F8 H3K27M mutations are dependent on a critical metabolic pathway also used by mIDH1 to regulate global H3K27me3 levels KDM6B HK2 EZH2 HEL-S-26 PMC9608452__F2 The microbiome and its metabolites in ankylosing spondylitis CXCL13 APC IL18 XBP1 PMC6971992__F2 ZIKV-induced ER stress initiates host cell unfolded protein response (UPR) ATF3 CHAC1 EDEM1 ATF4 EIF2A XBP1 PMC8097364__F2 Genome diversity and instability in human germ cells and preimplantation embryos FANCE ATR SMC6 BRCA1 BRCA2 FANCM FANCL FANCA BLM SSB PMC3835370__F5 Genomic Characterization of the Inherited Bone Marrow Failure Syndromes RPL11 NHP2 GAR1 RPS19 NOP10 RPS7 RPL35A RPS26 RPS29 SBDS RPS10 RPS24 RPS17 RPL26 PMC9433691__SF1 Compressive force regulates GSK-3B in osteoclasts contributing to alveolar bone resorption during orthodontic tooth movement in vivo APC MMP9 CTNNB1 PMC3920945__F3 Oncogenic and tumor suppressive autophagic pathways involved in miRNAs FOXO4 FOXO1 HDAC5 PMC4580556__F5 The debulking signature COMP SMAD1 TGFBI COL10A1 COL3A1 BMI1 TGFBR2 POSTN ACTA2 LOX GREM1 MMP2 TNFAIP6 SNAI2 TIMP3 FCGR2B CYP17A1 EGR1 ASPN CTSK FAP PRRX1 CXCL14 VCAN SOS2 GRB2 GATA4 PMC3825743__F5 Quantitative Phosphoproteomic Profiling of Human Non-Small Cell Lung Cancer Tumors CDC2 ATR BAD SOS1 PIK3C2A MTOR MEF2D RB1 FYN CAMK2D EP300 ATF7 ELK3 RRAS2 GAB2 PMC9420296__F2 Connecting telomere maintenance and regulation to the developmental origin and differentiation states of neuroblastoma tumor cells ATR TERF2IP ATM TERT POT1 TPP1 PMC9518657__F1 Control of aging by the renin–angiotensin system: a review of C. elegans, Drosophila, and mammals ACE2 PMC8554658__F1 Molecular mechanisms of chemo‐ and radiotherapy resistance and the potential implications for cancer treatment STAT3 CCND2 EGFR CTNNB1 PMC11671241__F7 Cortisol synthesis and secretion pathway and network of CRH‐ACTH‐cortisol signaling in Hu sheep MRAP STAR PBX1 LDLR MC2R PMC11671241__F5 Thyroid hormone synthesis pathway and network of TRH‐TSH‐TH signaling in Hu sheep ALB TH TG TTF2 TSHR HEL111 PAX8 TPO HEL-75 PMC11745090__F7 IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages STAT3 EGFR JAK1 PMC11671241__F6 Thermogenesis in Hu sheep RHEB COMP OMG FGF21 PMC4270061__F2 Cofilin pathway in breast cancer invasion and metastasis EGF EGFR RHO PMC6681775__F8 Regulatory mechanism of AQP1 in endometriosis WNT1 WNT4 AQP1 PMC8797698__F1 Immunotherapy and radiation for high-grade glioma: a narrative review TBK1 IL10 IDO1 AHR IRF3 IRF7 FOXP3 PMC6046295__F1 Mechanosignaling in normal keratinocytes and psoriasis CASR TH MTOR CTNNB1 PMC4270061__F1 Cofilin pathway in breast cancer invasion and metastasis CDC42 EGFR RHO SRC PMC7215894__F1 KLF11-mediated modulation of the TGFB signaling pathway in normal cells and tumors TIEG2 SIN3A SMAD4 TGFBR1 PMC10377897__F3 KV Channel-Interacting Proteins in the Neurological and Cardiovascular Systems: An Updated Review TF KLF4 NOTCH1 PMC2862867__F4 Sites of action of curcumin on cancer cells COX2 EGFR BCL2 VCAM1 ABCG2 PMC5452924__F1 Interaction of the E-cadherin-catenin complex APC SRC PMC5452924__F2 Operating mode of the E-cadherin-catenin complex in tumor metastasis EGF HGF EGFR APC GSK3B IQGAP1 WNT1 CCND1 CTNNB1 PMC8436916__F9 DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis ACAN DNMT3B TRPA1 COX2 MMP3 MMP9 PMC7846853__F1 PI3K pathway in the context of BCR signaling along with various targets STAT3 CD79B SYK CD79A BTK BCR CD19 PTEN NFATC1 LYN MYD88 PMC9688888__F9 Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway STAT3 BAX HMGB1 IL6 CCND1 FADD PMC140098__F7 A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer FHL2 RHO PMC2581798__F3 Information flow through the JNK network JUN IPP PINK1 SMG1 FER CDK2 FOS RET CDK4 PMC3035679__F3 Human inherited and mouse experimental defects in the cholesterol biosynthesis pathway that cause myelin disorders DHCR7 CYP27A1 ABCA1 PMC3035679__F4 Human inherited and mouse experimental defects in the glycosphingolipids synthesis pathway that cause myelin disorders UGCG FA2H SMPD1 PMC3378544__F4 Tamarindus indica Extract Alters Release of Alpha Enolase, Apolipoprotein A-I, Transthyretin and Rab GDP Dissociation Inhibitor Beta from HepG2 Cells LPL APOA4 ABCG8 HMGCR CD36 CYP7A1 PMC7827610__F1 Haem biosynthetic pathway and associated porphyria disorders HMBS AIP PMC5683102__F3 Loss of NLRX1 exacerbates neural tissue damage and NFKB Signaling following brain injury CD40 IL10 CASP8 TRADD RELB IRAK1 IRF1 TNF TRAF6 CCL2 IRAK4 MYD88 IFNG STAT1 BCL10 CARD10 NOD1 REL TRAF2 FADD BIRC3 PMC6947352__F11 Cell cycle pathway DBF4 CDK7 PCNA SMC3 SMAD4 CDK2 ORC3 SKP2 PMC8645889__F7 Hif-1A/Hsf1/Hsp70 signaling pathway regulates redox homeostasis and apoptosis in large yellow croaker (Larimichthys crocea) under environmental hypoxia BAX HSF1 PMC5135597__F1 Intracellular cholesterol landscape: dynamic integrator of the immune response OSBP VAPA IFITM3 LDLR CH25H PMC6034647__F1 From mice to men: TRPC3 in cerebellar ataxia CACNA1A ATXN1 PDYN TRPC3 PMC6025249__F7 Schematic diagram showing the mechanism of action of TFs against LPS-induced acute liver injury HMGB1 KEAP1 GCLM GCLC FASN IL1B PMC10898204__F5 KLF participates in the pyroptosis process of ulcerative enteritis through positive regulation of TXNIP/NLRP3 pathway KLF4 GSDMD NLRP3 TXNIP PMC5437570__F3 Interaction of antagonists with Wnt5A/Ryk signalling in vascular endothelial cells CTNNB1 HEL-S-15 PMC5373476__F7 Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis SOCS3 IL6 PMC6057448__F7 Death receptor signaling HTRA2 TBK1 FAS TRADD LIMK1 GAS2 DFFB ARHGDIB ROCK1 DFFA TRAF2 DIABLO LMNA FADD SPTAN1 PMC7834962__F1 IFN-related signaling pathways modulated by OncoTherad, zinc, vitamin D and glutamine during viral infections IRF3 MYD88 PMC7754001__F7 Schematic diagram for the signalling pathways related to the EMT and airway remodelling in response to TGF‐B1 DEK SMAD2 SMAD4 PMC4527592__F7 Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation HEL-S-68p PFKP HK2 HEL-S-162eP ENO1 HIF1A MICB HEL-S-87p PMC9166417__F1 PIKfyve as a drug target FIG4 PI3 PIP4P1 PTEN PIKFYVE PMC6274779__F5 DEGs involved in glycerolipid metabolism and fatty acid degradation pathway ACOX1 HEL-S-5 DGKE CPT2 PMC11788431__F8 C1GALT1-mediated regulation of Hh signaling and EWSR1::FLI1 expression EWSR1 SUFU SMO PMC4991353__F2 Canonical and non-canonical Wnt pathways have differing effects in cancer APC ROR2 ARF6 LRP5 LRP6 CTNNB1 PMC9647469__F3 Didang Tang inhibits intracerebral hemorrhage-induced neuronal injury via ASK1/MKK7/JNK signaling pathway, network pharmacology-based analyses combined with experimental validation PPARG NOS2 GRIN2B CASP9 JUN CSF2 CASP8 SLC2A4 PGR PTGS2 MMP9 MYC NR3C1 CTNNB1 NR1C1 IKBKB CASP3 KDR SRC CCNB1 GPT IL1B PMC3810304__F1 Potential pathways by which CKD modulates the accumulation of arterial macrophages CCR7 VCAM1 CCL2 PMC8675148__F2 Exploiting natural antiviral immunity for the control of pandemics: Lessons from Covid-19 TBK1 MAVS CCR2 IRF3 IL6 CCL2 MYD88 IFNAR2 PDC IFNAR1 CCL7 TYK2 IL1B PMC2808140__F2 Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host MAPK7 TRAF6 PMC6859545__F2 Cysteine residues are critical mediators of the antioxidant and heat shock responses KEAP1 HSF1 NFE2L2 PMC5884251__F1 Oncogene and tumor suppressor gene products regulate glucose and glutamine metabolism in cancer GOT2 PINK1 HEL-S-133P HK2 NEK2 PTEN TIGAR GLUD1 HEL-S-68p HEL-S-162eP ENO1 SCO2 GLS2 SIRT6 PMC9523668__F2 Targeting non-coding RNA H19: A potential therapeutic approach in pulmonary diseases STAT3 HMGB1 TGFB1 ROCK2 SIX1 EZH2 PTEN ARHA RUNX2 FTH1 COL1A1 NLRP3 NF1 TLR4 FGF9 PMC8945958__F1 Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives HMOX1 SLC3A2 LOX SP1 KEAP1 DHFR LPCAT3 FACL4 SLC7A11 PMC1410804__F7 Cdc42 regulates HF differentiation and cell–cell contacts in keratinocytes by modulating the turnover of Beta-catenin and plakoglobin CDC42 APC CTNNB1 PMC3934763__F7 Insulin signaling KEGG pathway in adipose tissue RHEB TSC2 BAD FAS CBL TSC1 INSR GSK3B GRB2 PDK2 MTOR INS PMC3934763__F8 PI3K-AKT signaling KEGG pathway in adipose tissue BAD RBL2 PTEN CD19 MTOR RAC1 IRS1 RHEB TSC2 BCR CD37 PI3 APIP MDM2 PMC12206661__F7 PI3K-AKT and Hippo pathways play important roles in the regulation of ovarian tumor cell proliferation and PD-L1 expression LATS1 LATS2 LAT PTEN LAT2 PMC4333457__F6 Proposed human innate immune signaling pathways activated during V STAT3 NOS2 OLFM4 OSM STAT2 IRF9 S100A8 IL17A TRAF6 MPO MYD88 STAT1 NLRP3 CASP4 TLR4 LCN2 JAK1 EPPK1 S100A9 TYK2 IL12B DEFA1B PMC9062100__F2 Toll-Like Receptors and Th Responses in Viral Myocarditis STAT3 TLR1 TLR3 TLR4 MAL IL18 TLR5 IRF7 TLR7 TLR10 IL1B MYD88 PMC8612763__F6 Metabolic changes associated with replicative lifespan (RLS) ENO1 GPD1 PMC9062100__F4 Toll-Like Receptors and Th Responses in Viral Myocarditis TH TLR3 TLR4 TRAF6 PMC3945033__F2 Computational simulation of eicosanoid profile in ATP-stimulated BMDM CTRL LTA ALOX5 HPGD PTGS1 ALOX15 PTGES PTGS2 PMC8016325__F6 Moringa isothiocyanate-1 regulates Nrf2 and NFKB pathway in response to LPS-driven sepsis and inflammation KEAP1 MAF IL6 PMC3679475__F1 Inflammatory adipokines suppress insulin signaling resulting in insulin resistance FOXO1 PTEN MTOR PMC5009362__F9 Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination MAP3K7IP1 TAB3 IRAK1 TRAF6 IRAK4 MYD88 PMC5592202__F5 Schematic drawing of the efferent signaling pathway of the inflammatory reflex in the context of the cholinergic system in immune cells CA4 ICAM2 CDA ChAT HEL-S-11 SLURP1 MYD88 PMC11482718__F10 Graphic summary of potential signaling pathway involved in MG-induced lipotoxicity in vitro and in vivo TG HMGCR FASN GLO1 PMC10665998__F6 Long non‑coding RNA PEG13 regulates endothelial cell senescence through the microRNA‑195/IRS1 axis VCAM1 MDM2 IRS1 PMC8242058__F6 Endoplasmic reticulum stress, chondrocyte apoptosis and oxidative stress in cartilage of broilers affected by spontaneous femoral head necrosis CASP9 CASP8 KEAP1 CASP3 BCL2 ATF4 ERO1A EIF2A ATG5 XBP1 PMC6441080__F7 The regulation of CP biosynthesis and the attachment to PG in S HEL-S-66 CP PMC8960436__F3 Celastrol Alleviates Autoimmune Hepatitis Through the PI3K/AKT Signaling Pathway Based on Network Pharmacology and Experiments NR1H4 PPARG SYK TIMP1 TGFB1 RAF1 EGFR HEL111 PIK3R1 MYC ACADM TGFBR1 HMOX1 STAT1 BCL2L1 BTK INSR F2 FGFR1 WAS MMP3 IL2 ITK FLT1 ELANE SRC CCND1 MAPK1 BAX NR1H3 CHIT1 HEL-S-7 SERPINA1 PTPN11 PTGS2 MMP9 VEGFA NR3C1 HRAS NR1C1 IGF1 CASP3 CYP2C9 GRB2 LCK PMC8835572__F2 Cancer as a Metabolic Disorder HEL-S-133P HK2 PTEN MYC PMC8829012__F3 HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease KIR2DL4 ZAP70 STAT3 HLA-G IL6R PMC8835572__F4 Cancer as a Metabolic Disorder ACLY ACSS2 FAS CD36 LDLR MTOR PMC6261125__F6 Transcriptome-wide identification of genes involved in Ascorbate–Glutathione cycle (Halliwell–Asada pathway) and related pathway for elucidating its role in antioxidative potential in finger millet (Eleusine coracana (L.)) SAG LTA PMC10030587__F2 Key events in cancer: Dysregulation of SREBPs FDXR MTOR TNF HEL-S-26 PMC5248531__F2 Mechanisms by which alteration of normal miRNA profiles can occur, leading to aberrant miRNA profiles in childhood solid tumours RAN DGCR8 XPO5 DICER1 TARBP2 MYC DROSHA PMC8003896__F3 Hcy metabolic pathways PMC8456981__F1 ROCK2 controls the balance between pro-inflammatory and Treg cell subsets, regulates cytoskeletal dynamics and profibrotic gene expression and drives both chronic inflammation and fibrosis in cGVHD LPA STAT3 ROCK2 JAK3 ARHA IRF4 FOXP3 PMC2790850__F2 Aberrant Myc expression causes mammary cancer USP28 BRCA1 ERBB2 MYC PMC9309761__F4 Analysis of Competitive Endogenous RNA Regulatory Network of Exosomal Breast Cancer Based on exoRBase ATR BAD PERP CD82 ATM CYC1 MYC PMC4120759__F1 ER stress and UPR ATF4 ASNS EIF2A PMC8638098__F5 Gene regulatory networks analysis of muscle-invasive bladder cancer subtypes using differential graphical model CD40 CXCR3 LTA GDF8 CSF1 OSM CCL15 IL3RA EPO IL36B CCL5 CCL23 XCR1 INHBE INHA CCL21 CCL7 GHR IL18RAP CCR8 CCL1 CCR1 BMPR2 IL17RC CXCR6 RELT TNFSF13 IL7R CXCL10 LTB CLCF1 IL25 TSLP IL17C CCL25 IL9R CCL4 BMP5 THPO CCL20 GDF9 IL12RB1 IL20RB TNLG5A CSF2RA CCL22 TNFRSF10C TGFB1 BMP8B INHBC IFNW1 BMP3 TNLG8A CCL26 NODAL CSF3 CSF3R TGFBR2 IL17B CSF2RB PPBP BMP4 ACKR3 XCL2 GHB2 CCR10 IFNA1 IL10 LEPR TNLG2B GDF6 BMP8A CNTF IL2RB IFNB1 IL13RA2 IL23A TNLG7C PMC6829385__F1 MAPK signaling pathway: ERK1/2, JNK1/2, and p38 EGF ATF2 TNF PMC8638098__F6 Gene regulatory networks analysis of muscle-invasive bladder cancer subtypes using differential graphical model PMCH PRLR ADORA2A CGA SCTR TBXA2R NMBR SSTR5 GHRL CHRM3 GABRR3 GABRG2 CHRM4 GRM4 DRD2 ADRA2B APLN GCK F2RL1 GHR VIP EDN3 ADM PENK F2RL3 SST CHRNG FPRL2 GABRA2 EDN1 EDNRA ADRB2 FPR2 PTGIR GRIA2 LEP HEL-S-62p GLRA2 PRH MC4R RXFP4 MC3R UCN3 GABBR2 HTR2A UCN2 GCGR PRLHR GRID2 GHRHR INSL3 CHRNB4 HTR2B LTB4R CHRNB3 HTR6 SSTR4 CCKBR GLRB CHRNA3 CHRNA2 CHRNA6 LPAR4 GLRA3 NPW P2RY2 CNR2 CHRNE TAC4 CHRNA10 GPR156 NR1A2 GRIA4 GABRQ P2RY10 GPR50 HCRTR2 P2RX5 TAC3 P2RX4 P2RX3 P2RX2 RLN2 KPG_011 RLN3 GZMA TACR3 TRHR NR3C1 CALCR CCKAR GCG DRD5 PTGER4 SCT GIPR PMC4595995__F3 HIV–tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling ECSIT TREM1 MAP3K7IP1 NOD2 SIGIRR TRAF1 TNF MYD88 PMC5953011__F1 Mechanisms regulating the canonical and non-canonical Wnt pathway SHANK3 DYRK1A APC CHD8 TBL1X PMC6477904__F1 Blnc1 assembles ribonucleoprotein transcriptional complexes with hnRNPU to form a positive regulatory loop with EBF2 and Zbtb7b EBF2 CELF1 ZBTB7B PMC7465322__F7 Possible functional network of the AR induction pathway in sugarcane MYC BAK1 PMC11734547__F6 Transcriptomics-based analysis of neurotoxic and reproductive effects in turbot (Scophthalmus maximus) after exposure to tris (2-chloroethyl) phosphate (TCEP) CDC42 GNRHR EGFR ITPR2 GRB2 PMC2857169__F5 NFKB in conventional T-cell activation APC IL5 PMC3382229__F4 Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis SLPI SYVN1 CXCL5 CCL15 DEFA4 APOL1 SFTPD HP NUTF2 PACSIN1 DEFA3 PMC6790333__F5 Cell motility in cancer invasion and metastasis: insights from simple model organisms SRC TNF FOS PMC5640840__F8 Schematic diagram showing the observed changes induced by HCV in endoglin-associated cell signaling pathways SMAD1 SOX2 BCL2 CCND1 ID1 HES1 SOX4 PMC9031373__F3 Evolving View of Uremic Toxicity EGFR AHR PMC2575612__F4 Inter-individual mRNA expression variances in the mitogen-activated protein kinase (MAPK) signaling pathway in rheumatoid arthritis (RA) compared with normal control (NC) POR MOK DAO PMC3382229__F5 Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis DEFA5 MMP7 DEFA4 DEFA6 DEFA1B DEFA3 PMC6111853__F2 Proposed working model for the role of Rho GTPases in S1P‐induced GEnC activation in the presence of MPO‐ANCA‐positive IgG S1PR1 S1PR3 S1PR2 ARHA RAC1 S1PR5 S1PR4 PMC2873439__F7 CXCR5 activate PI3K isoforms through GAlpha-Src-FAK pathway or via GB/G pathway leading to subsequent activation of ERK1/2 PI3 CXCR5 PTEN SRC DOCK2 PMC4557668__F8 JNK-dependent gene regulatory circuitry governs mesenchymal fate PCBP4 NR1H4 LMO7 CDX2 TCF12 NR2A1 ETV6 MEOX2 NFIL3 PMC5863732__F3 Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, Metabolic and Disease Implications SIRT3 ASL OTC ARG1 PMC10586807__SF3_1. Correlation between CRISPR KO and CRISPRa screen gene hits within certain pathways SOCS1 MAPK1 WNT3A TNFRSF1A MTOR TNF ATG10 STAT1 ATG3 BTRC AXIN1 RIPK1 AJUBA CCND1 PMC6161805__F5 Smoke-induced microRNAs and their target genes RPS15 DICER1 AGO2 SMAD2 SLC38A1 BRAF SMAD6 IL17A NR0B2 MAP2 XBP1 TUSC2 IL17B MAP2K1 BCL6 LMNA PMC3665639__F2 Cell cycle regulation of Golgi membrane dynamics STX5A PMC5983164__F2 RAS effector pathways TSC2 BAD TSC1 PTEN IRS1 PMC4580101__F5 How the embryo makes a limb: determination, polarity and identity HOXD10 HOXD13 HOXD12 HOXD11 HOXA13 HOXA10 SHH HOXA11 HAND2 FGF8 GLI3 PMC3712075__F6 Schematic diagram showing the involvement of CPT1C and ceramides in the hypothalamic ghrelin signaling pathway BSX NPY CPT1C AgRP CPT1A PMC2254585__F5 In silico knockout of PLCG1 in the HGF stimulated signalling network STAT3 SOS1 PTEN ATF2 GRB2 SRC PMC3490020__F1 The main MicroRNA biosynthetic pathway AGO1 AGO2 DROSHA PMC8995768__F1 Bone Morphogenetic Proteins Shape Treg Cells TGFBR2 BMPR2 ACVR2B ACVR2A ACVR1B BMPR1A SMAD6 ACVRL1 RUNX2 ID1 TGFBR1 PMC8422078__F1 Synthesis of GDP‐L‐fucose by the de novo and salvage pathway SLC35C1 FPGT FUCA1 FUOM GMDS POFUT1 PMC3857018__F1 Potential mechanism for active DNA methylation involving TET-mediated oxidation of 5mC, followed by TDG initiated BER pathway via recognition of 5hmC and 5fC (AP is an abasic site) (adapted from ()) TET2 TET1 TET3 TDG PMC9246655__F4 Insights from two independent transcriptomic studies of the bovine corpus luteum during pregnancy MAP3K1 TRIM24 PML SMARCD3 RDH12 PTEN ZBTB16 MAP3K5 PNPLA4 AKR1C4 DHRS3 PMC8624719__F3 Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC9327212__F1 Small biomarkers with massive impacts: PI3K/AKT/mTOR signalling and microRNA crosstalk regulate nasopharyngeal carcinoma RHEB RPS6 BAX BAD PTEN PMC9239783__F6 Exploration of the Molecular Mechanism of Danzhi Xiaoyao Powder in Endometrial Cancer through Network Pharmacology HRAS PMC8624719__F1 Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes TBK1 CGAS MAVS TLR3 MFN1 MFN2 IRF3 IRF7 TLR7 MYD88 PMC8624719__F2 Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes FADD MYD88 PMC5487853__F2 Representation of cilia-associated molecules that have been implicated in DNA damage responses (DDR) NEK8 CDC2 CEP164 ATR H2AX MDC1 PCM1 CEP63 OFD1 CDK2 ATM INPP5E CCNB1 PMC4747493__F8 Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer EGF EGFR DUSP4 IL6 PMC4565031__F2 Case study 1 (synthetic signaling pathway): Hypergraph showing every possible logic gate consistent with the prior knowledge network EGF RAF1 MAP3K1 EGFR MAP3K7 TRAF2 PMC9043318__F2 miRNAs Can Affect Intestinal Epithelial Barrier in Inflammatory Bowel Disease TLR4 IL1B MYD88 PMC8192809__F2 Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis ABCA1 PMC4978554__F1 CTLA-4 pathway inhibition CD80 APC PMC3898176__F2 Toll pathway TRAF2 FADD MYD88 PMC10963904__F4 Metabolic map of the L‐methionine synthesis pathway of E MAL THRA CIT PMC6324668__F1 Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins TDP1 ATR H2AX SLFN11 PMC10963904__F2 Metabolic map of the l‐methionine synthesis pathway of E MAL GLA THRA CIT PMC7292789__F1 Vertebrate complement cascades and the particular steps Lyme borreliae anti-complement protein interact FH HEL-S-62p C2 C1S C1R C9 C4A PMC8199487__F7 NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the Beta-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition BAX HDAC8 BCL2 BMX CCND1 MGMT CTNNB1 PMC10963904__F3 Metabolic map of the l‐methionine synthesis pathway of E TH MAL THRA CIT PMC230332__F7 Extracellular and intracellular antagonism of BMP signaling by myostatin and TGFB SMAD1 DKFZp781O1323 SMAD2 BMP2 BMP7 PMC3479242__F4 Optimizing the balance between host and environmental survival skills: lessons learned from Listeria monocytogenes MPL HEL-S-62p PTS PMC7786923__F8 Lnc-GAN1 repressed cell proliferation through cell cycle signaling pathway HEL-S-162eP PTEN CCND1 CDK4 PMC10742434__F1 Gut microbiota–host interplays in tryptophan and tyrosine metabolism, which affect mood and emotional states TH DBH ASMT PMC5524058__F8 Mechanisms of halofuginone action ATF4 EIF2A PMC3929326__F6 Regulation of Hippo-Yap1/Taz signaling by polarity complexes LATS1 LATS2 PATJ CRB3 AMOT SCRIB PALS1 NF2 PMC7182966__F3 Cancer hallmarks by the crosstalk between VEGF and Rho GTPase signaling pathways CDC42 PIGP ARHA SRC RAC1 PMC7926238__EV5 Models for disassembly of the metazoan replisome. The figure summarises data from this manuscript together with previous studies with early embryos of Caenorhabditis elegans and extracts of Xenopus laevis eggs UFD1L CDC45 TRAIP OFD1 MCM3 MCM5 MCM6 MCM2 PMC5684302__F2 Interrelationships between growth factor, nutrient availability and energy sensing pathways in metabolic regulation in health IGF1 IGF1R MTOR PMC5056494__F1 Signal transduction pathway mediated through CLEC-2 SYK BTK LAT SRC PMC5695117__F8 Proposed model for the autophagy process during E RHEB TSC2 TSC1 TFEB ATG14 PTEN ETF1 PMC4864533__F1 Signaling pathways downstream of Group I mGluR stimulation RHEB TSC2 TSC1 EIF4E PMC11928765__F2 Epithelial growth factor receptors (TGFBR/EGFR/KGFR) cellular signaling and their regulation by 16E5 STAT3 EGF ESRP1 HGF TGFA FRS2 EGFR SMAD2 SMAD4 FGF10 FGF2 RHEB TSC2 ESRP2 TSC1 GRB2 SMURF2 PMC5865411__F8 Proposed model for the novel dual functions of toll-like receptor (TLR)-10 in regulating IFN signaling SARM1 TLR3 IRF7 TLR10 MYD88 PMC3369892__F8 Summary diagram of the proposed adrenomedullin (ADM) signaling pathway in the retina RAMP3 RAMP2 ADM PMC3306173__F6 Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis TBK1 TLR3 IRF3 IRF7 PMC3419830__F1 Mechanisms of action for therapeutic agents in treating or preventing HAE HEL-S-62p PLG PMC5740757__F4 Interaction pathway of miR-1270 and target genes PARVG SP1 SOS1 CREB5 STAT2 ITCH TBL1X KSR1 STK4 IRF8 GABBR1 CRK FOSL2 PREX1 CREB3L2 MAML3 INSR PDPK1 PRKX DVL3 LYN CDC37 GAB2 ULK2 PMC6781492__F3 PPI networks and GO and KEGG pathway analyses for the top two positively co-expressed hub modules of SNHG7 in thyroid cancer RPS15A EIF3F RPL10 RPL31 RPL12 RPSA RPS19 RPL23 RPS7 RPS29 RPS20 RPS24 SART1 LSM7 SYF2 RNPS1 SNRPC RPL14 RPL7 RPL22 RPS5 EEF1G RPS27A PPP2R1A U2AF1 RPL4 RPS9 RPL26 RPL8 RPL32 RPS14 FBL RPL36AL RPL36 RPL38 SNRPD3 RPL37 TXNL4A RPS11 RPS8 MRPS18A GTF2F1 RPS3A PRPF6 MRTO4 CD2BP2 SNRPE RPL29 RPL28 RPS17 SNRPB MRPL17 RRP7A CPSF1 MRPL27 LSM4 NACA LSM2 TBL3 RPL27A TPT1 RPS21 RPS23 DDX49 SMG9 EIF3K RPS4X RPL7A MRPL2 NOB1 CTNNBL1 MRPS2 PABPN1 IMPDH2 POLR2F RPL13 POLR2H POLR2J RPL19 RPL3 SF3A2 RPL23A EIF3G EIF3E PRPF31 FAU EIF3D RPL35 PPIE RPL18 IMP3 PPIH IMP4 XAB2 HEL-S-310 RPLP2 RPL30 RPS16 RPL39 RPS13 RPS3 RPL27 BUD31 SNRPA RPL34 RPL11 RPS2 RPL6 RPL13A RPL10A RPS25 RPS12 REL PMC6781492__F4 Bioinformatics analyses for the top two negatively co-expressed hub modules of SNHG7 in thyroid cancer COG5 DYNLL2 PJA2 PIK3CA ATR KLHL20 KLHL9 KLHL5 ITCH GOLGB1 STAG1 MAPRE1 PPP2R5C PPP2R5E HUWE1 TRIP12 CLASP2 PI3 RECQL TRIM37 WAPAL GOLPH3 UBR1 RAD50 UBE3C HECTD1 SPTBN1 SMC1A VHL TP53BP1 RANBP2 WWP1 UBE2H PAFAH1B1 NEDD4 PRKDC UBA6 GOSR1 LTN1 RNF6 CDC27 REV3L RNF111 COG6 PMC4656203__F1 Folate transport and folate mediated 1-carbon metabolism in eukaryotic cells (for gene abbreviations and enzyme commission numbers, see and , respectively) MTHFD2 RFC1 ABCC1 FOLR3 HEL-S-70p HEL-S-51e FTCD AMT SHMT1 MTHFD1L GGH MTHFS FPGS PMC5548025__F7 A model of mTOR signaling pathways involved in AS CCR7 MTOR ABCA1 SIRT1 PMC5846794__F6 Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy PIK3CA SHC1 EGFR SMAD2 PIK3R1 SNTA1 SMAD4 KCNJ12 ACTN2 PRPF40A ACTA1 MAPK8 PTPN13 NCF1 MAPK3 KIF23 MAPK14 CAMK2A ITPKA CHUK MAPK12 DMD SRC YWHAG DAG1 TNFSF6 ACTN4 CAMK2D FOXO3A NFKB1 IKBKB GRB2 GAB2 YWHAZ LCK PMC8063416__F2 Still’ disease interactome a considering all disease effectors and their direct interactors and b focusing on disease effectors and their interaction to drug targets, and comparison to c pathway enrichment results of sJIA gene expression data PPARG CSF1 S100A8 TLR9 C1QB SOCS3 CXCL8 MYD88 IL-21 HMOX1 INHBA MMP3 MIP RAB27A IFNGR1 IL18R1 TNFSF6 IFNA2 CXCL10 CXCL11 IL12B FAS IL2RA SQSTM1 CS C4A IL18BP UNC13D NCR1 NCR2 NCAM1 SH2D1A CX3CL1 IL18 TLR7 ATG5 IL1B HMGB1 IL13 IL4 IL17A IL6 C1QA C2 NFKB1 RELA S100A12 S100A9 IL23A PMC4940627__F6 Schematic diagram of the mechanism of THs regulating gallstone formation in vivoFXR/RXR heterodimers which mediate phosphatidylcholine and bile salt transporters (ABC-B4 and ABC-B11) are down-regulated by THs ABCG8 ABCG5 ABCB11 ABCB4 LDLR PC PMC7288469__F4 CFTR Proteostasis Interactors RNF185 SYK DNAJB1 SIN3A STX6 SYVN1 DNAJC5 DNAJB12 SEC16A DERL1 RFFL HEL-S-102 CFTR PMC5192315__F2 Toll-like receptor signaling pathways ECSIT TK1 TIRAP IL16 TLR4 RELA IRAK1 TRAF6 MYD88 PMC4183827__F9 Proposed DAT/PAT, sulfolipid, and phthiocerol dimycocerosate biosynthetic pathways CHP2 MPL MMP17 CHP1 PMC4351453__F8 A proposed model of our study is shown UCP2 MTOR STC1 PMC5327616__F9 BM-MSC modulates inflammation response through mTORC1-p70S6K/mTORC2-Akt Signal Pathway STAT3 MLST8 RICTOR TLR4 CASP3 MSC MTOR IL1B PMC4008360__F3 Ingenuity pathway network analysis of differentially expressed miRNAs ENPP4 DRD2 CA13 MYZAP WDR35 IL11 CREB1 PMC2708980__F8 Proposed signaling pathway BAX RASGRP3 BCL2 PMC12187936__F3 Anti- and pro-tumoral immunity regulated by tumor-resident bacteria CHI3L1 IFNG ARG1 MPO PMC6690202__F1 Main pathways of NFKB activation CD40 TRADD TAB3 RELB REL PMC5240041__F3 Intracellular signaling pathways in lymphangiogenesis VEGFC MTOR RAC1 PMC5589692__F6 P38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells CDC42 FYN LIMK1 MAPKAPK2 VEGFA PMC5589692__F7 P38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells SRC CTNNB1 PMC11878248__F2 Predicted targets of host miRNA responsive to HSV-1 infection SOCS1 PMC3836475__F4 Gene network associated with IFN pathway signaling ADAR MS4A1 GBP7 IFIT3 IFIH1 NR4A3 IFIT2 CMPK2 VCP ISG20 GBP5 STAT1 RTP4 PARP12 IFI44 USP18 RNF114 EPSTI1 MX2 FBXO39 MX1 GPR141 ZNFX1 OAS1 GBP2 OAS2 USP25 FAT10 UBA7 STAT2 PARP14 LGALS3BP IRF9 IRGM XCL1 IRF1 SP110 IRF7 GBP1 OAS3 ATF3 CDKN1A IFI27 PMC8073701__F5 Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer CREB3L3 TF CGA EGFR CRTC2 CREM ATF2 TRAF3 PCK1 NFIL3 SOX9 ATF1 ATF7 POLR2A HDAC2 CEBPB KMT2B CREB1 ZBTB21 BARX2 TSSK4 JUN HEL-S-8a TLR1 NFYA CREBBP HLF EP300 PMC4808796__F1 ATM, ATR and DNA-PK signalling pathways TOPBP1 ATR ATRIP MRE11A BRCA1 RNF168 RNF8 ATM MDC1 PMC3595301__F1 Canonical or Wnt/Beta-catenin–TCF/LEF signaling CDC42 DKK1 APC ROR2 GSK3B RYK ARHA LEF1 CTNNB1 PMC3595301__F3 Crosstalk between Wnt and local inflammatory signaling pathways for the control of SVZ niche homeostasis GSK3B WNT1 CTNNB1 PMC6643140__F7 Proposed mechanisms of TRIP13 functions in BCa TRIP13 EGFR ID1 PMC7296543__F1 Canonical signaling pathway of TLRs TBK1 TIRAP TLR9 CD14 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 LBP PMC6909891__F1 Mechanistic target of rapamycin complex 1 (mTORC1) and mTORC2 signaling pathway and function TSC2 TSC1 IGF1 ULK1 PMC102186__F9 Ras-mediated signaling pathways NRAS ATF2 ARHA RHO RAC1 PMC7498644__F2 Activation of the canonical NLRP3 inflammasome NLRP3 IL18 IL1B MYD88 PMC3663908__F1 Major signaling pathways leading to cellular apoptosis HTRA2 BAX BAD FADD PMC2952128__F4 Functional gene networks identified using IPA from differentially expressed genes between control and 300 nM reversine-treated annulus fibrosus cells KRT20 TTC14 TNLG2A VPS33A DNAJB4 TLL1 CD55 PAX7 ORM2 CKAP2 BMI1 BTG2 HEL-S-14 ITGA6 HEL-S-66 AHNAK HCTP4 PMC8161229__F3 Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis TH FANCA PMC5837202__F3 Effect of PCB126 exposure on the calcium signaling pathway PLN CAV3 CAV2 TNC BCR MCU PMC4458453__F1 Pathway of eukaryotic translation initiation ELF1 SUI1 ELF3 PMC9266809__F6 miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR YY1 MTOR PMC4489351__F1 EDA pathway and its downstream signaling EDARADD TRAF6 EDAR TNLG7C PMC9121316__F1 Forward single‐cell sequencing into clinical application: Understanding of ageing and rejuvenation from clinical observation to single‐cell solution TOX MTOR PMC9374747__F4 In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states TF PGP IRS1 PMC6755815__F6 The pathway by which LPA increases LPP3 expression LPA RELA RELB PMC6682839__F3 Cell death and survival in the contrast of susceptible vs TRIO TFDP1 IFRD1 MSMO1 NACC2 NRP1 TPST1 GINM1 PROX1 FOSL2 WDFY3 HPGD ATXN1 NRF1 PMC6462535__F6 Ethanol regulation of stem cell differentiation via activation of RA signaling CRABP2 LRAT RBP4 RDH10 ALDH1A2 DHRS3 PMC10418437__F1 Signaling pathways activated by free mtDNA in the pathogenesis of metabolic syndrome TBK1 CGAS NLRP3 TAB3 TLR9 IRF3 IRF7 TRAF6 IL1B MYD88 PMC9374747__F6 In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states KLF4 TF RREB1 EGR1 HOMEZ RFX1 HOXC6 MYOG NR1C1 PKNOX1 PBX3 SP100 RELA ETV4 ZBTB16 PMC3744328__F1 Sumoylation and regulation of cardiac gene expression HDAC1 SAE1 XPC PMC3408825__F1 Autophagy pathway: signaling systems and three proposed membrane sources in autophagosome formation HMGB1 NLRP3 AIM2 IL1B PMC6715590__F1 NLRP3 inflammasome activation pathway NLRP3 IL16 TLR4 IL1B PMC12034127__F3 Iron overload activates the AKT/mTORC1 signalling pathway and inhibits TFEB expression, thereby inhibiting autophagy-mediated degradation of misfolded Alpha-syn and leading to neuronal death TF TFEB IGF2 PMC9454487__F1 Transforming Growth Factor-Beta Signaling in Cancer-Induced Cachexia: From Molecular Pathways to the Clinics SMAD2 RYR1 NOX4 PMC6174659__F1 P53 transcriptional pathway GML BAX ATF3 EGF TGFA PCNA MAP4 EGFR BCL2 ATM MDM2 PMC9454487__F2 Transforming Growth Factor-Beta Signaling in Cancer-Induced Cachexia: From Molecular Pathways to the Clinics SMAD2 SMAD4 PMC2724047__F6 Activation of the Akt (insulin signaling pathway) and FXR by bile acids in hepatocytes EGFR SRC PMC8080632__F8 Schematic diagram illustrating the theory in the current study ARHA NEUROD2 PMC7080523__F4 Innate immune regulation of cGAS‐STING‐mediated immune pathways by the host or viral elements CD80 CGAS IFI16 IRF3 IRF7 JAK1 TYK2 HBZ MYD88 PMC2724047__F5 Major cell signaling pathways activated by bile acids in hepatocytes CDC42 ERBB3 HRAS FGFR4 ERBB2 PMC7861567__F5 Mild hyperandrogenemia in presence/absence of a high-fat, Western-style diet alters secretory phase endometrial transcriptome in nonhuman primates ESRRA CCDC17 RBL1 ZNF333 TCF7L2 JUN FOXO4 E2F4 EZH2 TCF4 MYC CCND1 PMC4836034__F1 Autophagy pathway and its interaction with HSV-1 TBK1 KIAA0226 ULK1 UVRAG SQSTM1 EIF2A ULK2 EIF2AK2 PMC8086039__F1 Kill Two Birds with One Stone: Role of the RIPK-3 in Necroptosis and Inflammasome Activation RIPK3 NLRP3 MLKL MCU PMC6112260__F9 Protein-protein interaction networks of DEGs involved in the staphylococcus aureus infection signaling pathway RPL8 RPS15 NAALADL2 RPL35 HEL-S-62p RPS14 OTULIN RPL36 TUBB6 FLNA RPS16 RPL5 CSNK2A1 FNDC4 HEL2 MED23 RPL31 RPL12 RPS4X CFD RPL7A TUBB8 SQLE HEL70 RNF149 SET PURA GIT2 PDE3B HLA-DMA EIF3CL EMC6 TRFP RPS28 DDX19B HLA-DRB3 RPS25 RPS9 HLA-A PMC9389037__F1 The macrophage-to-myofibroblast transition in renal fibrosis SMAD2 JAK3 SMAD4 SRC PMC9693478__F3 Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex MRAP FRZB SHH ZNRF3 EZH2 MC2R SMO WNT4 RSPO3 AXIN2 WNT2B CTNNB1 PMC6828748__F4 Molecular pathway linked to oxidative stress response in E ADRM1 PSMD2 PMC1794588__F3 Small subnetwork identified for the shift from glucose to ethanol as carbon source MAL PKIA AIDA PMC3018162__F1 Schematic and mathematical representations of the main model assumptions GAA CSA2 SI PMC4026741__F1 Pattern recognition receptors in respiratory anti-viral immunity JUN TLR3 IRF3 JAK1 SRC TRAF6 FOS TYK2 PMC9585227__F1 Lipids for CD8+ TILs: Beneficial or harmful? IFNG STAT3 PPARG CD36 LDLR TNF CPT1A LAG3 PMC4197041__F1 Getting ready for building: signaling and autophagosome biogenesis STAT3 EGFR ULK1 SLC7A5 TRAF6 MYD88 RHEB TSC2 TSC1 TLR4 GRB2 EIF2A GAB2 PMC6939855__F1 Mechanisms of endocrine therapy resistance in ER+ breast cancer and treatment strategy PMS1 DDR1 NEIL2 PMS2 NF1 PI3 ATM CDK4 PMC9081983__F3 Non-Coding RNA in Neurological Complications Associated With Enterovirus 71 IRAK3 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 PMC4641492__F1 A lncRNA to repair DNA BRCA1 ATM HNRNPUL1 PMC8889147__F3 Network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease PPARG GLS ACADSB EBP NR1C2 ADRB3 ALB TPO ABCB1 CYP1A2 ACHE CYP21A2 REST DBH SQLE PTGS2 NR3C1 NR1C1 CXCR1 OGDH PPT1 ADRB2 ESD ADRB1 SLCO1A2 PMC6728077__F1 DCs modulate Tfh-2 responses through the IL-6/STAT3 signaling pathway STAT3 CXCR5 GATA3 PMC3496878__F4 Phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling pathway in cell proliferation in solid cancer TSC2 TSC1 EIF4EBP1 PTEN MTOR EIF4E PMC3496878__F1 Signal transduction in solid cancer cells including hepatocellular carcinoma CDC42 STAT3 JUN BAD FAS EGFR APC CYC1 PTEN MTOR FAP RHO FOS CRK MOS NF1 GRB2 SRC PMC8115630__F6 Relative abundance of respective enzymes involved in central carbon metabolic pathways in “Ca. B. sinica” based on proteomeic analysis HEL107 RPE SDHA SDHB HEL-S-162eP PC HEL-S-26 PMC8684084__F4 Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of osteosarcoma cancer MYB SYK PIK3CA SOS1 MCL1 GSK3B CRTC2 MYC BCL2L1 PDPK1 FGFR4 PRKCA PKN3 MDM2 TNFSF6 IRS1 EIF4E HRAS RHEB MLST8 TSC2 TSC1 BRCA1 CDKN1B RXRA CDK2 BCL2 GRB2 BAD STK11 DDIT4 AKT3 PTEN MTOR PCK1 YWHAQ PHLPP2 MTCP1 CHUK CCND1 RPTOR RPS6 RBL2 CD19 RAC1 ITGB1 GYS1 FOXO3A NFKB1 CDC37 GNG11 PMC3780793__F1 Genes identified in the phosphatidylinositol and hedgehog signaling pathways PIP5K1A PLCD3 CSNK1G2 CDS2 GAS GSK3B DGKB PTEN PIP4K2A CDIPT LCT PI3 BMP4 PRKCA SMO WNT4 RAB23 PI4KB OCRL ZIC2 PMC6690396__F3 Histone methylation-dependent DDR mechanisms MSH6 RNF168 SETD2 PMC3335850__F1 Gene Expression Analysis Implicates a Death Receptor Pathway in Schizophrenia Pathology BAX TNFSF13 BCL2 FADD PMC10229232__F1 Krüppel-homologue 1 regulates the development of Tuta absoluta and its cascade regulation pattern in the juvenile hormone signalling pathway AGO1 RPL32 CDC6 PMC11856996__F3 Inhibitory Effect and Mechanism of Hexanal on the Maturation of Peach-Shaped Phallus impudicus ROM1 C2 PI3 MIB1 PTEN HP PMC8495394__F3 P38G in Cancer: From review to outlook TF SUZ12 ERBB4 F3 CTNNB1 GATA3 PMC8495394__F1 P38G in Cancer: From review to outlook REST CCNE1 PMC6546959__F4 Proposed ternatin biosynthetic pathway GCG HEL-S-62p C2 GC PMC3348384__F1 miRNAs and estrogen action FUS RAN EWSR1 DGCR8 AGO2 DROSHA NCL PMC9540541__F2 Metabolic engineering of oleaginous yeast Rhodotorula toruloides for overproduction of triacetic acid lactone TH AMPD1 ME1 PEX10 PMC8287254__F1 Lactate as Potential Mediators for Exercise-Induced Positive Effects on Neuroplasticity and Cerebrovascular Plasticity FNDC5 HCAR1 VEGFA BDNF PMC11765629__F6 Metabolic pathway genes and metabolites altered in patients with MacTel SPTLC2 HEL-S-182mP PHGDH DHFR SPTLC1 GCKR HEL-S-61p GCK MTR PSPH PMC4727530__F2 BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics BAD EGFR BRAF MTOR KRAS PMC2673958__F1 Role of Adenomatous Polyposis Coli (APC) and Microtubules in Directional Cell Migration and Neuronal Polarization CDC42 APC RHO PMC7539770__F3 Influence of the SRSF1 splicing factor on malignancy through AKT signalling RHEB TSC2 TSC1 EIF4E PMC8749970__F2 Tumor-Associated Macrophages in Hepatocellular Carcinoma Pathogenesis, Prognosis and Therapy IL10 CCL18 IL6 CXCL10 CCL2 CCL20 CTNNB1 PMC11121235__F8 N-glycan metabolic pathway GCS1 DPM2 ALG11 ALG9 ALG13 GANAB DPM3 PMC8625973__F1 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy LATS1 LATS2 VASP ITCH AMOT ARHA NF2 RUNX3 PMC8625973__F2 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy LATS1 LATS2 NF2 CAMTA1 PMC8625973__F5 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy LATS1 WBP2 LATS2 WWC3 PMC8625973__F6 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy LATS1 WBP2 LATS2 WWC3 PMC8625973__F7 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy DDX5 WBP2 DGCR8 ITCH DROSHA PMC11986138__F1 Expression changes of genes associated with protein processing in the endoplasmic reticulum by the correction of LRRK2 by BAC DNA SVIP ATR RBX1 CASP12 PAG1 PC ATF4 PMC2713831__F5 Local Network Topology in Human Protein Interaction Data Predicts Functional Association BMPR2 ACVR2B SKIL JUN ACVR2A TGFBI INHBC IGSF1 PML TGFBR3 SKI pp6425 TGFBR1 ENG INHBB SMURF1 INHBA HIPK2 INHA SMURF2 GDF9 RNF111 STRAP PMC10792990__F4 Mechanism of GB on independent risk factors for atherosclerosis STAT3 TG TLR4 PMC5985050__F8 Proposed mechanisms by which PPARB/D regulates VLDLR levels and hepatic steatosis.PparB/D deficiency may result in an increase in VLDLR levels and hepatic steatosis through several mechanisms TG VLDLR FGF21 FGFR1 ATF4 EIF2A PMC3560376__F2 The TLR9-Notch ligand (dll4) on Mycobacterium-dependent granuloma formation TH CCL22 DLL4 CCR6 TLR9 CCL20 MYD88 PMC4727530__F1 BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics BAX BAD BMF HRK BIK PMC3060910__F1 Notch-2 Gene Is Regulated by Wnt Signaling in Cultured Colorectal Cancer Cells MAML1 HEY2 HES3 APC NUMB LFNG MFNG HES7 CTNNB1 HES5 PMC2612083__F1 Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder CORT NMB CRH BDNF TNF AVP PMC4042299__F3 The role of epigenetics in the biology of multiple myeloma SOCS1 STAT3 CDK6 WIF1 CDK4 CTNNB1 PMC8974835__F1 Pharmacological Rationale for Targeting IL-17 in Asthma C6 EGFR TRAF6 NOTCH1 FGF2 PMC6963149__F2 Aberrant expression of long non-coding RNAs (lncRNAs) is involved in brain glioma development EGFR OCEL1 PTEN MDM2 MTOR SHE DAO PMC5292133__F3 Network of the genes related with post-translational modification, cancer, and tumor morphology RBMX CASP12 RTN2 USP11 CSDC2 MYC RIPK3 LAMP2 CA12 CDK7 PTCH1 ADK INCENP BCAT1 ELK3 UHRF1 TPMT PMC8625973__F8 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy WBP2 LATS2 WWC3 USF1 PMC5292133__F4 Network of the genes related with cancer and DNA replication, recombination, and repair PPIC IFRD1 ARF6 PLK4 PHLDA1 MED1 MAOA RBL1 TFRC IL16 SRC POLE ITGB5 PMC9599649__F2 Cyclosporine A Delivery Platform for Veterinary Ophthalmology—A New Concept for Advanced Ophthalmology CDC42 VAV2 DBI RAC1 PMC7614835__S1 Purine Biosynthetic Pathway, the Pathway Transforms PRPP (Phosphoribosyl Pyrophosphate) into IMP (Inosine Monophosphate) in 10 Biosynthetic Stepsa ASL PMC2928685__F1 Schematic diagram of the interaction of HH signalling on p53 and Nanog SAG SOX2 PC SMO PTEN MDM2 PMC11854632__F1 Effects of miR-21 on key signaling pathways involved in SCI, with a focus on axonal regeneration, apoptosis, and inflammation STAT3 BAX BAD CASP8 ROR2 PTEN MTOR CTNNB1 CNTFR CNTF NGF GFAP CASP3 BDNF CCND1 FADD PMC3324922__F3 ALDH1A1 pathway JUP TH GSK3B FZD9 SMAD6 DVL2 SNCAIP FOS CTNNB1 KCNB1 FRAT1 DRD2 SLC6A3 SLC18A2 PITX3 LEF1 PMC3324922__F4 NOS3 pathway GATA2 TH KLF2 THBS1 ESAM GSK3B ACTN2 SLCO2A1 ENG COL18A1 ACTN4 ELF1 IKBKB LIPE TNFSF10 AVP PMC6407676__F10 TGFB inducible epithelial-to-mesenchymal transition in renal cell carcinoma TGFBR2 SMAD2 SMAD4 MMP2 TGFBR1 PMC4108799__F3 HMGB1 binding to receptors and activating signal transduction pathway CXCL12 HMGB1 LTA TIRAP TLR4 TLR9 CXCR4 MYD88 PMC6895093__F15 Apoptosis adapted from KEGG (ID: hsa04210), the know targets were signed in red; (B,C) the insulin signaling pathway adapted from KEGG (ID: hsa04910) the predicted targets and other human proteins were signed in red RHEB TSC2 BAD FAS ATM INS OTOF PMC4404103__F2 RNA Sequencing Reveals a Slow to Fast Muscle Fiber Type Transition after Olanzapine Infusion in Rats IDH3B CS SLC16A3 SUCLG1 SUCLA2 HEL-S-32 MDH2 PFKM GOT2 FH ACO2 HEL-S-133P HK2 LDHB HEL-S-30 SDHD SDHA SDHB PGAM2 ENO3 FBP2 HEL-S-68p OGDH HEL-S-162eP SUCLG2 DLD HEL-S-87p SDHC PMC2967585__F9 Mechanisms involved in alcohol-mediated suppression of type I IFN pathway in human hepatocytes STAT1 STAT2 SOCS2 IRF3 SOCS3 JAK1 TYK2 PMC8449753__F1 How FGF23 shapes multiple organs in chronic kidney disease NR1i1 GALNT3 ORAI1 EPO HIF1A PTH PTH1R FGF23 PMC4001041__F1 Schematic illustrating NLR attenuation of canonical and non-canonical NFKB signaling CD40 NLRP12 NLRX1 NLRC3 RELB IRAK1 TRAF3 TRAF6 MYD88 PMC8027489__F1 PI3K/Akt/mTOR signaling and its main components CENPO TSC2 BAD TSC1 CDK2 PTEN MDM2 JAK1 IRS1 PMC11942534__F3 5-Methylcytosine Methylation-Linked Hippo Pathway Molecular Interactions Regulate Lipid Metabolism LATS1 MOB1A PMC11942534__F4 5-Methylcytosine Methylation-Linked Hippo Pathway Molecular Interactions Regulate Lipid Metabolism LATS1 MOB1A FAS PMC8712723__F1 Evasion of I Interferon-Mediated Innate Immunity by Pseudorabies Virus CSA2 TBK1 CGAS STAT2 IRF9 PML TLR9 EPO IRF3 IRF7 MYD88 ISG20 STAT1 IFNAR1 JAK1 TYK2 PMC4169022__F3 Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma SACS SERPINF2 CDC20 HMMR RXRG PDE4B CTSG PCK1 GNAS RGS7 BACH1 SMARCE1 MED29 PPBP TYROBP SP100 CLU IRAK3 POMC PTGFR SMC4 VWF ESAM PDE10A INPP5D TACR3 NR3C1 FFAR1 CD44 PTGDR NCOR2 IRF2 SIRPA BCL2 CENPA EGR2 PMC5457776__F1 Insulin resistance in obesity TLR4 IRS1 PMC7216265__F3 lncRNAs affect glutaminolysis pathway in cancer SIRT3 GLS OGDH ME2 ME1 TUG1 PMC7216265__F4 Cancer glutaminolysis pathways through circRNAs GLS IGF2 CTNNB1 PMC7216265__F1 Canonical glutaminolysis pathway ACLY HEL60 GLS ACO2 FASN ME1 PIG59 SLC7A3 HEL-S-32 ATF4 MDH2 ASNS GLS2 HEL-S-26 PRODH GPT PMC7216265__F2 miRNAs affect glutaminolysis in cancer MAX ACO2 GLS PMC3474187__F9 Methionine sulfoxide and methionine sulfoxide reductase (MSR) redox cycle MSRA CTH PMC9145045__F2 Type I and Type II Interferon Antagonism Strategies Used by Paramyxoviridae: Previous and New Discoveries, in Comparison TBK1 MAVS TLR9 IRF3 IRF7 TRAF3 TNF IRAK4 MYD88 RIGI TRIM25 TLR3 TLR8 TLR7 PMC9145045__F3 Type I and Type II Interferon Antagonism Strategies Used by Paramyxoviridae: Previous and New Discoveries, in Comparison IFNGR2 DDB1 IRF9 ISG15 TYK2 PMC6715589__F2 APP regulation of mitochondrial OXPHOS metabolism BAD INSR APP PMC7409348__F5 Graphic representation of signaling pathways that promote gastric cancer PTEN BDNF PMC4949263__F2 Horizontal cell fate and cell type formation LHX1 ISL1 FOXN4 PTF1A PMC6503447__F9 Prospective model for clarifying the role and regulation of ATG5 and ATG7 on autophagy and ER stress ATF4 EIF2A ATG5 PMC6199358__F1 (Left) In the “off” state, Beta-catenin binds with glycogen synthase kinase 3B (GSK3B), axin2, adenomatous colon polyposis protein (APC), and casein kinase-1 (CK- 1) APC LRP5 LRP6 CCND1 AXIN2 CTNNB1 PMC5559174__F14 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome RHEB IGF1 ELF2 IL6 RHO MTOR SIRT1 PMC6199358__F2 The Wnt/Beta-catenin and other signaling pathways APC GSK3B LEF1 CTNNB1 PMC8498718__F3 RNA-seq profile of African American men with a clinically localized prostate cancer UVSSA LRP2BP SELENOW PMC7506056__F9 Aucubin attenuates liver ischemia-reperfusion injury by inhibiting the HMGB1/TLR-4/NFKB signaling pathway, oxidative stress, and apoptosis IL16 IRF1 MYD88 PMC4288522__F1 Intracellular signaling of mTORC1 and mTORC2 RHEB TSC2 TSC1 SGK1 NF1 PTEN NF2 DEPTOR IRS1 PMC4116802__F2 Inflammation induces B cell activation STAT3 BCR MYD88 PMC3293571__F7 EMT downstream of TGFB and HMGA2 HMGA2 ZEB2 PMC6628971__F1 Molecular mechanisms of the cGAS/STING pathway as a senescence-associated DNA damage sensor and inflammation trigger RPE TBK1 CGAS IRF3 PMC11975009__F2 VPS35 in Neurodegenerative Diseases FUS TREM2 VPS35 CDK5 HEL-S-130P BACE1 SLC4A11 LRP6 CTNNB1 PMC9019781__F1 WT1: The Hinge Between Anemia Correction and Cancer Development in Chronic Kidney Disease WT1 EPO VHL PMC6748047__F2 Protein pathway analysis using serum proteins present in healthy controls and/or AA patients BMP10 DKK4 FRZB THBS1 HGF SELL CLEC7A PPIF TNFRSF4 PDGFA PRKCZ DDR2 TNLG2B MPO TEC NID2 PARD3 DKK1 KREMEN1 BCL2 CNTN4 SGTA SELP CCL17 PMC8437933__F7 Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway FST PMC6705454__F8 Modulation of IGF-1R expression levels is sufficient to restore the AKT/CREB and ERK/Elk-1 intracellular signaling pathway activation profile, resulting in SMN expression increase in SMA mice IGF1 SMN1 IGF1R PMC7830527__F2 Proposed IFN-Gamma-dependent mechanisms of hyperprogression FAS NLRP3 IDO1 TLR4 CXCL5 IL8RB PMC7830527__F3 Proposed CD38-dependent mechanisms of hyperprogression ADORA2A IGF1 HIF1A IGF1R ANGPT2 IGF2 UNK PMC3233625__F3 Pleiotropic functions of EAPII/TTRAP/TDP2 CD40 SMAD2 PMC5963710__F7 Nonhuman primate kidney transcriptome in fetal development DVL1 PPARG SIAH1 LEP ROCK2 APC GSK3B LRP5 SMAD4 LRP6 ARHA PSEN1 MYC RBX1 BTRC CER1 SKP1 NLK DAAM1 WIF1 PMC4239504__F2 Molecule-mediated signal pathways in the propagation of liver cancer during liver regeneration SMAD1 DKFZp781O1323 SMAD2 SMAD4 MTOR PMC9559313__F1 Targeting Glucose Metabolism Enzymes in Cancer Treatment: Current and Emerging Strategies ENG FAS ALDOB HK2 AIP HEL-S-87p PMC4191248__F2 Pancreatic cancer pathway diagram page EGF TGFA PTEN ANO7 KRAS PMC3698421__F10 Schematic presentation of the Wnt signaling pathway APC LRP5 LRP6 CTNNB1 PMC3976613__F2 Non-selective autophagy regulation during diabetic nephropathy (DN) RHEB TSC2 RICTOR TSC1 IGF1 UVRAG PMC9164466__F7 FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion GSDMD FANCC IL1B PMC3712052__F1 Analysis strategy (–) to identify the putative regulatory effect of GWAS candidate () on FRMD3 regulation (), linking the gene to transcriptional regulation of the BMP pathway (–) and DN and suggesting a hypothetical regulatory model () FRMD3 MAP3K7 KRAS PMC11392662__F8 Domperidone, a Dopamine Receptor D2 Antagonist, Induces Apoptosis by Inhibiting the ERK/STAT3-Mediated Pathway in Human Colon Cancer HCT116 Cells STAT3 DRD2 PMC7528617__F6 Analysis of HIF-1 signaling pathway STAT3 HEL-S-162eP EPO HEL-S-11 ENO1 VHL EIF4E PMC4191248__F3 Hypoxia-inducible factor pathway SAT2 OS9 HIF1AN AMT EP300 VHL PMC4191248__F6 Renal cell cancer pathway SDHD FH ACD PMC7311976__F1 Wnt/Beta-catenin signaling pathway RNF43 PORCN APC LRP5 ZNRF3 LRP6 CTNNB1 PMC7311976__F4 Ubiquitination in the Wnt signaling pathway SIAH1 RNF146 ITCH APC LRP5 LRP6 FANCL HUWE1 CTNNB1 SMURF1 RNF43 NEDD4 ZNRF3 SMURF2 PLEKHA4 NARF PMC7311976__F5 Deubiquitination in the Wnt signaling pathway USP25 USP44 USP51 USP34 APC LRP5 LRP6 USP9X CTNNB1 USP14 USP4 USP47 CYLD USP6 PMC8821659__F4 Comparative Study of Bacillus amyloliquefaciens X030 on the Intestinal Flora and Antibacterial Activity Against Aeromonas of Grass Carp ABAT OTC PDK2 CIT PMC3198061__F3 In individuals with high macrophage aggregation around dead adipocytes as CLS, activation stimuli such as IL-1, lipopolysaccharide (LPS) and lipopolysaccharide binding protein (LBP), and TNFA bind to their appropriate membrane receptors TLR4 CD14 MMP9 LBP IRS1 PMC9314411__F8 Proposed model of the UVB-triggered biochemical pathways in human dermal fibroblasts BAX EGF BCL2 ATM PMC9031497__F4 Impact of Maternal Feed Restriction at Different Stages of Gestation on the Proteomic Profile of the Newborn Skeletal Muscle ECHS1 HEL60 ENO2 HEL-S-30 PDHA1 DLAT PIG59 OGDH HEL-S-162eP PDC DLD AGL HEL-S-26 PFKM PMC449769__F7 A model connecting telomere damage signalling and senescence-associated replicative arrest ATR H2AX ATM PMC11832533__F9 Brief Introduction to the Functions of lncRNAs (Wilusz et al RAB10 MCM5 EZH2 PLK1 TUG1 PMC5411440__F1 Cellular and molecular pathogenesis of Helicobacter pylori infection in gastric carcinogenesis MAX STAT3 CDH17 RASSF1 APC GSK3B SMAD4 HIF1A GKN1 CTNNB1 MYD88 CD44 COX2 TLR4 BCL2 PMC7649776__F4 Psychiatric and cognitive SNPs mark eQTLs that are associated with gene expression within the neurotrophin signaling pathway CDC42 BAX CRK NGF BAD FRS2 APP ARHA GRB2 SHE TRAF6 IRS1 PMC3188357__F2 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), is the major genotoxic heterocyclic amine generated from cooking meats at high temperatures CYP1A2 CYP1B1 CYP1A1 PHIP PMC8173334__F1 Diabetes and Cardiovascular Complications: The Epidemics Continue IRF9 PTMS IRF7 IRF4 PMC9174413__F7 Comparative proteomic analysis on chloroplast proteins provides new insights into the effects of low temperature in sugar beet PRX PC PMC3875938__F1 The mechanisms of Wnt/Beta-catenin pathway repression by 1,25(OH)2D3 in human colon carcinoma cells NR1i1 LRP5 LRP6 TCF4 CCND1 CTNNB1 PMC8083961__F3 Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration CDC2 IGF1 ERBB4 WEE1 ERBB2 IGF1R MTOR SIRT1 EIF4E PMC8268912__F1 Brain Symptoms of Tuberous Sclerosis Complex: Pathogenesis and Treatment RHEB TSC2 TSC1 NF1 ULK1 PTEN DEPDC5 EIF4E PMC2757648__F3 Interferon response genes are coordinately upregulated relative to the rs17445836 allele of IRF8 SOCS1 NCF2 IFIT1 S100A8 IFIH1 PML TLR9 IFIT2 CTSS PIN1 SPI1 INHBA LILRA2 TLR4 CHUK MX2 CSF1R GPR65 AOAH MXD1 LRCH4 IRF7 IFNA2 AGER IFNAR1 S100A9 PMC10984535__F6 Pathway dynamics of islets during diabetes progression FKBP5 CCKAR CCK FOXO1 FOXO3A HK2 SMAD2 CACNA1B RIPK1 PTEN PMC11354572__F1 Serum TLR2 and TLR9 in Prostate Cancer Patients in Relation to EBV Status CGAS MAVS TLR3 TLR9 AIM2 IFI16 IRF3 IRF7 TLR7 MYD88 PMC7943466__F4 General mechanism of MP formation, its mode of action, and the proposed possible impacts of diets on MPs that could be linked with CSVD TF PC VCAM1 RHO PMC10532491__F5 EGFR signal transduction pathway—an overview (modified after [94]) RB1 FUS PIK3CA ALK AXL EGFR BRAF PTEN MDM2 MTOR KRAS RET PMC3096494__F1 Regulation of Interleukin-10 Gene Expression in Macrophages Engulfing Apoptotic Cells SP1 TLR4 PBX1 CD14 MEIS1 PMC4061247__F3 Nuclear Trafficking in Health and Disease RANBP1 LRPPRC EIF4E PMC8502122__F1 Comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori PURB GPT PMC10532491__F2 Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer EGF HGF TGFA EGFR ERBB2 GRB2 PMC10532491__F3 Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer STAT3 STAT1 EGF EGFR AREG PMC3614848__F2 STRING interaction for proteins studied to find relevant networks in RCC BAX BIRC5 SLC2A4 SLC2A2 BCL2 SLC2A3 HIF1A KDR MDM2 VEGFA CA9 VHL PMC11941256__F1 BMP signaling pathway BMP6 BMP4 BMP2 BMP7 RHO BMP5 PMC7957592__F7 Influence of TP53 on FAM72 paralogs directly regulates the cell cycle in cancer ATR MYBL2 MCL1 CYCS PTEN RB1 BCL2L1 CASP6 CHEK2 ATM MDM2 SRGAP2 BAX CASP9 E2F2 TFDP1 FAM72D RBL2 FAM72B FAM72A RBL1 CASP3 CHEK1 CDK2 BCL2 BAK1 DIABLO PMC9119177__F7 Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways TRADD CD14 ATM HAMP MX1 TNF PMC5818912__F4 The ADAM17/EGFR axis ADAM17 EGFR AREG NOTCH1 PMC3674623__F6 Effect of sodium ferulate on caspase cascade apoptosis and IKK/NFKB pathways induced by TNF/TNF receptor TRADD TNF TRAF2 FADD PMC5818912__F7 ADAM17/EGFR signaling an important player in CF and COPD lung disease STAT3 EGFR AREG PMC5412308__F4 DEGs protein–protein interaction (PIP) network complex and modular analysis CCNA2 CXCL3 EPHB2 BIRC5 SERPINB5 CDCA5 INHBA SOX9 PTGS1 GCNT3 KCNMA1 BCHE GHR MMP7 CENPF ACSL6 P2RY1 MMP10 AGTR1 EZH2 AHCYL2 FAP AQP8 BEST2 UBE2T S100P CLDN2 SLC4A4 SCN9A CXCL11 KRT6B EPHB3 UGT2B15 PAPSS2 SCNN1B TCEA3 SLC9A9 COL4A6 ZG16 MT1E CDCA7 CEP72 CENPA OSBPL3 TCN1 PIGR ONECUT2 CCL20 HEPACAM2 CHP2 KIF15 ENC1 CXCL12 DLGAP5 OXGR1 HELLS CKAP2L SETBP1 MYOT CKS2 CXCL1 POLR1D ABI3BP LRRC8E LGI1 CENPE GALNT6 PCK1 ODAM SLC26A2 FABP6 PRKCB POU2AF1 PCSK9 DCLK1 tmp_locus_29 GDF15 ADAM12 DBF4 GNAI1 LRP8 ITLN1 SLC5A1 RRM2 KIT LPAR1 IRF4 CXCL6 NR3C1 SLC12A2 CHI3L1 NR3C2 CLCA1 CCL28 RUNX1 HSD17B2 FOXA2 HCTP4 SKA3 HEL164 MND1 NCAPG NEK2 KIF20A NMU MMP11 ITGA2 MEIS1 CDKN3 TRIB3 LMNB2 SFRP4 CCL19 CDC45 HSD11B2 GINS2 TOX MB MUC4 AKAP12 LAMA1 HMMR BRCA2 E2F7 SLC7A11 COL10A1 NOX4 PPBP TTK CCNB1 ERCC6L CDCA2 CDC2 CEACAM1 GNG4 NUF2 CXCL2 GREM2 ESCO2 LIPG MAD2L1 TESC GCG SPC25 SULT2B1 RAD51AP1 CENPW KIF18A CLDN1 PF4 PMC3202828__F5 Cif hijacks several and various signaling pathways by inhibiting the ubiquitin ligase activity of CRL CDT1 ARHA CTNNB1 PMC6065367__F8 Proposed mechanism for TSPO ligand-induced ATP release TSPO2 PBR PMC12215448__F4 Interaction of CD8+ NKT-like cells, CD8+ T cells and GDT cells with NK cells CD48 CD244 TNFRSF1B TNF PMC5566109__F5 CircRNAs and the related signaling pathways in human cancers CDK6 CCNE1 ITCH PRR11 EGFR PIK3CD TCF2 CDK2 CTNNB1 PMC9607849__F1 Development of a Chiral Supercritical Fluid Chromatography–Tandem Mass Spectrometry and Reversed-Phase Liquid Chromatography–Tandem Mass Spectrometry Platform for the Quantitative Metabolic Profiling of Octadecanoid Oxylipins LOX GLA ALOXE3 PMC11953509__F7 NEK2 promotes cancer cell progression and 5-fluorouracil resistance via the Wnt/Beta-catenin signaling pathway in colorectal cancer APC NEK2 CCND1 CTNNB1 PMC8660639__F7 Proposed mechanistic scheme of PCID2 in promoting the canonical Wnt signaling pathway in colorectal cancer PCID2 PML CCND1 CTNNB1 PMC3724648__F6 Model showing the effects of PP2A in SLE T-cells SP1 ELF1 TNLG8A SUI1 PMC5964874__F4 MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs MAX ECSIT EGF JUND FAS RAF1 EGFR CD14 TNF TRAF6 FLNA MEF2C NGF C2 MOS HP NLK GRB2 BDNF TRAF2 PMC4571158__F2 A schematic presentation of secreted, endocytic, and signaling pattern-recognition receptors HEL-S-62p C2 C4A C4B_2 PMC11671673__F8 Schematic diagram about working model of YTHDC1 YTHDC1 PIK3R3 RXRA EIF3A RPL37 PMC6345383__F2 PDA cells have a remarkable ability to adapt to nutrient fluctuations and targeted therapies GOT2 GLS HEL-S-32 ME1 PMC12068294__F2 Bioactivities of stem cells cultured on fish-derived biomaterials GPR32 GPR18 TLR4 PMC5454963__F1 Proposed action mechanisms of glutamine in intestinal cells STAT3 STAT1 STAT4 MTOR PMC4148147__F7 Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells MAVS PDC F7 IRAK1 IRF7 TLR7 TRAF3 TNF MYD88 PMC9406534__F3 TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer TBK1 MAVS IRF3 TRAF2 PMC3617098__F1 Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 SSB PARP1 PMC3620319__F3 An Integrated Approach to Uncover Driver Genes in Breast Cancer Methylation Genomes HDAC1 E2F2 TRAF2 PMC10937645__F8 Proposed model of the recognition of bacteriophage DNA by the animal immune system TBK1 CGAS TLR9 IRAK1 IRF3 IRF7 TRAF6 IRAK4 MYD88 PMC6378054__F1 UPR signaling cascade GLS ATF4 EIF2A PMC9406534__F2 TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer CAP2 RELB CAP1 TRAF2 PMC10305623__F1 11-oxygenated androgens in prostate cancer SRD5A2 HSD17B6 HSD3B1 HSD17B2 PC AKR1C2 PMC4922205__F2 BCR-ABL1 Signaling Network BCR COIL MTOR SKP2 GAB2 PMC3076281__F2 Sphingolipid effects on intrinsic and extrinsic apoptotic pathways BAX BAD FAS TRADD TNF FADD PMC3076281__F3 Effect of sphingolipids on the PI3K/AKT pathway CASP9 BAD PTEN MDM2 MTOR PMC6274856__F1 Cartoon showing the major signaling pathways targeted by phytochemicals in cancer EIF4B RAF1 PTEN MTOR PMC6862031__F5 Summary of altered metabolic pathways and regulatory mechanism of rFIP-nha against A549 cells TSC2 HEL-S-162eP PTEN TIGAR SCO2 MTOR GLS2 PMC7856101__F2 Gut Microbiota in Epigenetic Regulation of Colorectal Cancer STAT3 TLR4 CTNNB1 PMC7926694__F6 Emerging effect of ferroptosis in malaria immunity TF STEAP3 GPX4 SLC7A11 GLS2 PMC9283764__F4 Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0) SCARB2 PPARG FGF13 RAB14 HCST SNAP29 AHR CENPE NR1C2 TBP TNF PMC8065509__F2 LTBR signaling pathway in lymphatic endothelial cell (LEC) LTBR TRADD TRAF3 TRAF2 PMC3627549__F6 Decreased Hepatotoxic Bile Acid Composition and Altered Synthesis in Progressive Human Nonalcoholic Fatty Liver Disease AKR1D1 CYP8B1 BAAT GCA HSD3B7 CYP7B1 CYP27A1 PMC6098968__F1 Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums CASP9 JUN BAD GSK3B PTEN MTOR MYC FOS IRS1 CTNNB1 RHEB TSC2 RICTOR APP MDM2 GRB2 PMC9036297__F4 Uncovering Novel Pre-Treatment Molecular Biomarkers for Anti-TNF Therapeutic Response in Patients with Crohn’s Disease CRK BAD RHOD PMC3736540__F1 Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: A Key Signalling Pathway in Infection-Induced Preterm Labour TLR4 IRF3 MYD88 PMC5580529__F3 Proposed model for the regulation of synaptic restructuring by Wnt during learning (from ) APC GSK3B CTNNB1 PMC8385607__F5 Pima Indian Contributions to Our Understanding of Diabetic Kidney Disease CRAT PIM1 MTOR CEBPB PMC7532113__F1 ERBB family comprises four receptor tyrosine kinases including the epidermal growth factor receptor (EGFR) NRG1 IGF1R GRB2 MTOR PMC8746762__F12 The mechanism behind the inhibition of the TGF-Alpha-induced HCC cell migration by raloxifene and bazedoxifene TGFA EGFR PMC11901933__F8 Reparative potential of LF in UVB-exposed HaCaT cells SMAD2 HAS2 PMC3666377__F3 Functional Beta-cells respond to increasing glucose levels by increasing insulin secretion GLIS3 TIEG2 KIF11 PDX1 NEUROD1 RFX6 PAX4 PTF1A TCF2 FOXP3 GCK HNF1A PMC9240200__F2 Vicious Cycle: In Severe and Critically Ill COVID-19 Patients STAT3 TLR4 ACE2 PMC7336871__F2 Physical approximation of APP and BACE-1 - a key event in Alzheimer’s disease pathogenesis SNAPIN CD2AP SNX15 BACE1 SNX4 BIN1 NUMB APP SNX27 PACS1 PMC8888693__F1 Using a Systems Approach to Explore the Mechanisms of Interaction Between Severe Covid-19 and Its Coronary Heart Disease Complications TH IGF1 CROT VCAM1 MIF TNF PMC3319201__F3 Primary therapeutic targets in the Ras downstream signaling pathway NF1 PTEN RHO NF2 MTOR PMC12104164__F3 Signaling pathways related to fibrocartilageThe complex network of interrelated signaling pathways is involved in the generation of fibrocartilage, including TGFB/SMAD, WNT/Beta-catenin, Hippo, PI3K/AKT, and NFKB LATS1 TF LATS2 TEAD2 TEAD3 RELA COIL PTEN MTOR LEF1 TEAD4 CTNNB1 PMC3559989__F6 Bayesian regulatory network and optimal regulatory pathway of p42.3 protein S100A4 HEL-S-43 SP1 ROCK1 PTEN RHO VHL PMC7946937__F4 Rewired signal pathways by deregulated Myc in cancer and its related components available for synthetic lethality CDC2 PRKDC BUD31 XBP1 PMC4837572__F3 Synaptic transmission: lipid-protein interactions CDC42 GSK3B MARCKS NCS1 SRC PMC8491037__F1 Triacylglycerol remodeling in Physaria fendleri indicates oil accumulation is dynamic and not a metabolic endpoint LPA DAG1 HEL-S-5 PC PMC8495584__F3 Research progress on evodiamine, a bioactive alkaloid of Evodiae fructus: Focus on its anti-cancer activity and bioavailability (Review) STAT3 BAX MTOR PMC4707441__F2 Tetraspanins organize the T-cell immunological synapse CD81 CD80 PLAT CD9 APC CD82 CD151 RHO PMC5378187__F2 Plant-parasitic nematodes: towards understanding molecular players in stress responses PRX PMC4197207__F3 PRR signaling in testicular cells TLR3 TLR4 TLR5 MYD88 PMC8491037__F7 Triacylglycerol remodeling in Physaria fendleri indicates oil accumulation is dynamic and not a metabolic endpoint LPA HEL-S-5 PC PMC10723546__F3 Biological pathways in ccRCC ARID1A SUZ12 ATR EED BRAF PTEN HIF1A MTOR SETD2 RBBP7 MDM4 CDKN2A FBXW7 PBRM1 ARID2 ATM MDM2 RPL22 SMARCA4 EZH2 KRAS VHL HEL-117 TSC2 CREBBP EP300 USP20 PTH MAP2K1 MAP2K2 UHRF1 ELOC PMC8024119__F5 Enhanced activity of the RAS-MAPK signaling pathway due to the loss-of-function mutation of the NF1 gene and mode of selumetinib action RAF1 NF1 BRAF GRB2 PMC9185151__F1 InterferonA and its effects on cancer cell apoptosis STAT1 STAT2 IRF9 JAK1 TYK2 PMC5590790__F1 Molecular mechanism underlying cardiovascular diseases associated with the changing of intracellular Ca2+ through TRPCs TG TRPC6 TRPC3 PMC3661940__F1 Intrinsic somatodendritic and presynaptic modulation of action potential (AP) firing and transmitter release in 5-HT neurons CCK CX3CR1 GALR3 GALR2 PMC8431803__F1 Chlorpyrifos Disrupts Acetylcholine Metabolism Across Model Blood-Brain Barrier ACHE CYP2B6 CPO ChAT CP PMC5445933__F3 Main pathways altered in GEMMs of cutaneous melanoma HGF CDK2 PTEN MDM2 MTOR RET PMC6338564__F5 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses GLS NAMPT MYC PRODH SIRT1 PMC6338564__F6 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses ATM PTEN MYC PMC4641522__F4 Paradigm for testing the multiple independent mechanisms that reinforce IDO1-mediated immunosuppression in malignant glioma FOXO1 IDO1 APC SOCS3 SLN IDO2 PMC8082504__F10 Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway HMOX1 PIK3CA IL18 NFE2L2 NTRK2 GPX3 BDNF PMC5154770__F1 Naïve T cells are predominantly oxidative and constantly monitor their environment for immune insult IL15 MTOR MYC PMC7793984__F1 LMP agents and biological factors that induce lysosomal rupture and cell death LAMP2 NPC1 PC PMC3047044__F1 Simplified schematic version of the epidermal growth factor receptor (EGFR) signaling cascade EGF TGFA EGFR BRAF GRB2 PMC2817383__F4 Putative host signaling pathway induced by Y STAT3 STAT2 LIF IL33 PTGES DUSP16 MIP BAK1 LPP MYD88 PMC6423493__F5 GRP78 mediates hypoxia-induced EMT through smad2/3 and SRC/MAPK signaling SMAD2 SRC PMC9085754__F4 MALAT1 as master regulator of biomarkers predictive of pan-cancer multi-drug resistance in the context of recalcitrant NRAS signaling pathway identified using systems-oriented approach FOXD1 JUND EGR1 SP1 JUNB SMAD2 SPARC HIF1A FOS GATA3 NFIA CD44 TCF7L2 CEBPA RUNX1 NFKB1 RELA TFAP2C PMC6251060__F1 Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease ATG101 ATG10 ATG3 ATG12 ULK1 UVRAG AMBRA1 BCL2 STX17 ATG5 DEPTOR PMC6715306__F1 Extrinsic and intrinsic cues regulate the oligodendrocyte program ID2 PTEN TCF4 SOX10 MTOR YY1 RHO NRG1 FYN IGF1 MBP PDGFRA ID4 SHH BDNF OLIG1 SOX5 HES5 PMC6251060__F4 Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease PINK1 MFN1 FUNDC1 PMC4947555__F3 Histological chorioamnionitis shapes the neonatal transcriptomic immune response CEBPE PIM2 FOXO3A ANXA2 SPI1 PMC8898355__F1 Ferroptosis by Amino Acid Metabolism in Cancer GPX4 FES MTOR PMC9370123__F2 Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies TH RFC1 TPH2 PMC6042401__F8 Alterations in CREB signaling POLL POLI GRB2 TBP PMC7391667__F3 Direct pathway of m6A to regulate transcriptome a Two possible mechanisms of eIF3 regulating mRNA translation initiation MGA YTHDC1 METTL14 YTHDF2 YTHDF1 ELF3 YTHDC2 PMC8638425__F4 Insights into high-risk multiple myeloma from an analysis of the role of PHF19 in cancer EZH1 PHF19 SUZ12 EED EGR1 MCL1 EZH2 HIF1A MYC REN CDKN1A MVP BCL2 CDKN1C LZTFL1 LHPP PMC7510328__F2 MET and/or RON activation, signaling pathway, and biological consequence HGF EGFR MCL1 APC BCL2 IGF1R GRB2 MTOR CTNNB1 VHL PMC3744227__F1 Chemopreventive potential of natural compounds in head and neck cancer EGF EGFR RELA GSK3B MDM2 MTOR CTNNB1 PMC6409601__F4 Hypermodification of m5C34 in anticodon of cytoplasmic and mitochondrial tRNAs ALKBH1 NSUN2 NSUN3 FTSJ1 PMC2666381__F1 TLR signaling and the role of epithelium in corneal innate defense CSA2 LTA MAL TLR9 TLR5 IRF3 IRF7 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 TLR7 PMC9622788__F1 Regulatory necrosis in traumatic brain injury TRADD MLKL GSK3B CHMP4B ARC ME1 CYLD TRAF2 PMC9622788__F2 Regulatory necrosis in traumatic brain injury GSDMD NLRP3 PGAM5 TLR4 AIM2 ACE2 IL1B PMC4870750__F8 Seasonal bias in toll-like receptor (TLR) signalling pathway TBK1 PIK3CA MAPK11 TIRAP IKBKE TLR9 IRAK1 TRAF3 TRAF6 IRAK4 IKBKG MAPK3 MYD88 MAPK14 MAP2K6 RIPK1 TRIL CTSK TLR5 IRF3 IRF7 SPP1 MAP3K7IP1 TLR3 NFKB1 IKBKB MAP3K7 MAP2K1 FADD PMC4260725__F2 Major signaling pathway regulation and core machinery of autophagy ATG101 ATG10 ATG3 ATG12 ATG5 PMC9622788__F4 Regulatory necrosis in traumatic brain injury RIPK3 GSDMD TRADD BNIP3 MIF PMC1064894__F3 Toll-like receptor (TLR) signaling pathways TLR1 TLR3 TIRAP TLR4 TLR9 TLR5 IRF3 TLR7 TRAF6 MYD88 PMC10380946__F3 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer BAX BAD FAS TRADD EGFR ABO MTOR ABCA1 APAF1 TRAF2 FADD PMC12066790__F10 Oncogenic mechanisms of HTLV-1 in adult T-cell leukemia/lymphoma STAT3 PCNA CARD11 IRF4 MYC HBZ HAX1 BIRC5 TIGIT FBXW7 RNF8 CCR4 FOXP3 LAG3 PMC10380946__F4 Illustrates the apoptosis mechanisms triggered by DHA STAT3 BAD FAS TRADD OSGIN1 EGFR PTEN MTOR SDC1 TNF XBP1 TLR4 ATF4 EIF2A APAF1 FADD PMC10380946__F1 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer BAX BAD APAF1 PMC6899527__F3 Single-Cell Sequencing of ChAT/vAChT-Positive Cortical Cells and Analysis of Their Expressed TranscriptsExpression values were normalized (0–1) for each dataset TF CHRM1 GAD1 CHRM3 PRIMA1 IL6R CHRNB4 COLQ CHRNB3 CHRNA3 CHRNA2 CHRM4 CHRNA6 ISL1 CHRNB2 CHRNA10 BCHE OLIG1 VIP ACHE CHRM5 CHRNA5 NGFR LIF CHRNA7 GBX1 NTRK2 SLC18A3 RBFOX3 SLC5A7 LHX6 SST LHX8 GBX2 CNTFR CNTF GFAP CHRM2 NKX2-1 NTRK1 AIF1 ChAT IL6ST JAK1 TYK2 PMC10380946__F2 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer BAX BAD FAS H2AX APAF1 FADD PMC10380946__F7 ARA on apoptotic death pathways FAS HEL-S-28 EIF2A APAF1 FADD PMC8187247__F1 Antiviral strategies targeting herpesviruses NECTIN2 PDGFA PMC10380946__F5 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer BAX BAD FAS PTEN APAF1 FADD PMC10380946__F6 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer BAX BAD APAF1 PMC6216032__F4 Smad-dependent/independent transforming growth factor-beta signaling pathways TF ATF3 ARHA PMC10531214__F3 Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications STAT3 STAT1 STAT5B STAT2 JAK3 STAT4 IL6ST JAK1 TYK2 PMC10531214__F4 Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications IL19 IL24 LIF PMC10295928__F6 MiRNA-assisted immunotherapy CCL4 PTEN JAK1 PMC11625190__F1 Biosynthetic pathway of 1-phenylethylisoquinoline-derived PIAs ADH7 DDC PMC10295928__F5 MiRNA-assisted targeted therapy HGF AXL EGFR IGF1R MTOR KRAS IGF2 IRS1 SPP1 RHEB CD44 MUC1 SHH HDAC2 PMC6965651__F8 ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD MKRN1 CASP3 FADD PMC3601164__F3 Links between Toll-like receptor 4 and breast cancer TBK1 TLR4 IRF3 TRAF3 MYD88 PMC8488570__F3 The CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting STAT3 CCR2 MTOR CCL2 PMC4277955__F1 Interleukin-22 signaling pathway STAT3 JAK1 TYK2 PMC3601164__F2 Links between Toll-like receptor 4 and breast cancer TLR4 IRAK1 TRAF6 MYD88 PMC8909150__F1 Genomic and Epigenomic Landscape of Juvenile Myelomonocytic Leukemia CBL NF1 GRB2 KRAS GAB2 PMC11976435__F1 Wnt/Beta-Catenin signaling pathway DKK1 APC LRP5 LRP6 CTNNB1 PMC11851563__F2 Beta-Catenin and DNA repair pathways PRMT1 ERCC1 XPA FZD5 ATR PMS2 PCNA MYBL2 BRCA2 GSK3B TCF4 CTNNB1 CDX2 ATM TDG MGMT HMGB1 MSH6 SIAH1 RAD51 MSH2 MSH3 FEN1 PKP2 PARP1 BRCA1 RUVBL1 PMC8600818__F9 Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1A/miR-210/Rad52 pathway RAD52 H2AX ATM PMC6071762__F1 Biosynthesis of glycerophospholipids and sphingolipids in mammalian cells PGP HEL-S-5 PC PMC6658087__F9 Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice CCS KEAP1 SLC2A4 HK2 CYCS CYC1 FABP4 SLC25A3 CS MPC1 MPC2 SLC25A22 SLC27A1 MTFP1 DNAJC15 TIMM50 SLC25A18 SLC25A51 TOMM5 MFN2 HEL-S-5 SLC38A4 TIMM23 PMC6293111__F6 Model depicting the molecular function of Lsm12 LSM12 PCNA POLN PMC11851563__F1 Canonical Wnt signaling pathway APC GSK3B CTNNB1 PMC6071762__F5 Apparent unidirectional fluxes of the LTP-mediated inter-organelle transport of lipids are indirectly coupled with metabolic reactions of lipids OSBP PC PCTP PMC11976435__F2 Non-canonical Wnt signaling pathway LRP5 LRP6 ARHA DAAM2 NLK DAAM1 PMC6658087__F5 Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice ABI2 GATA2 STAT3 SYK VEGFC C3AR1 ABL2 TBXA2R HIF1A MYC IKBKG ADRB3 IFNG WT1 ANGPT1 SNAI1 CD93 IRAK3 NFKBIZ NOS2 FCGR2B SP1 SERPING1 LIF YBX1 IL17A TNF IL17RA BRCA1 FOSL1 EDN1 ATP1A4 TP63 NFKBIA POU2F1 REL GJA1 PMC3108205__F4 Delay in apoptosis at 9 hr HTRA2 BAX CAST BAD FAS CAD MCL1 APP TNF DIABLO PMC4909382__F7 Schematic depiction of the antiapoptotic conditions including the PRL signaling pathway in young RPE versus the proapoptotic conditions in aging RPE PRLR RPE PRL SIRT2 PMC3720859__F4 Capacity of Aptamers to Trigger Immune Activation in Human Blood TIRAP APP LPP LBP MYD88 PMC2920202__F2 Spatial-temporal signals determine the fate of activated CD8+ T cells IL15 CD40 CD2 ID2 CD27 TNLG8A PMC2785495__F3 Response of heterogeneous ribonuclear proteins (hnRNP) to ionizing radiation and their involvement in DNA damage repair ATR ATM MDM2 HNRNPK PMC3490606__F1 Reactions involved in the flux of fatty acids into LPA FAS HEL-S-5 PDC PC PMC1855986__F9 ATM-Mediated Transcriptional and Developmental Responses to Gamma-rays in Arabidopsis ATR CYCS WEE1 ATM PMC8013731__F8 Toll-like receptor signaling pathway and NF-kappa B signaling pathway regulated by the S100s alteration in HCC CD40 TLR3 ELL CTSK CD14 CPO TNF RAC1 LBP IRAK4 FADD PMC2833340__F1 Plane facts of PCP in the CNS CDC42 ATR VASP ROR2 CTHRC1 PTK7 PMC6689252__F6 Extinction-dependent network of genes in morphine-treated rats CCL27 ADCYAP1R1 GAP43 FUT4 CREM ASAH2 DRD2 NTF3 CNR1 GFRA2 GRIA4 RASGRP4 FLNB PARG PER2 NTRK2 SHE RHEB OPRD1 PEBP4 GMFG CYP46A1 ChAT VTCN1 ZDHHC8 REL TRPC3 MMD DEFB114 PRKG1 EMCN PMC3219092__F3 Nox regulation of the PI3K/AKT pathway BAD FOXO1 PTEN SRC PMC6757184__F1 Wnt/Beta-catenin signaling as a useful therapeutic target in hepatoblastoma EGF GSK3B SLC38A1 FHL2 CTNNB1 PMC3825518__F1 From Evolution to Revolution: miRNAs as Pharmacological Targets for Modulating Cholesterol Efflux and Reverse Cholesterol Transport TG ABCG1 LDLR PREB ABCA1 PMC4284388__F3 Platelet signaling induced by GPIb-IX-V and required for AIIbB3 activation VWF SYK PLCG2 PI3 LYN SRC RAC1 PMC4172484__F7 Amygdala-dependent fear memory consolidation via miR-34a and Notch signaling HES1 PMC4882019__F3 Temporal Expression of Peripheral Blood Leukocyte Biomarkers in a Macaca fascicularis Infection Model of Tuberculosis; Comparison with Human Datasets and Analysis with Parametric/Non-parametric Tools for Improved Diagnostic Biomarker Identification CPVL STAT1 PPBP DGIC CD93 CASP3 CD163 ApoL6 FOS KNG1 BIRC3 PMC8901678__F1 Hepatic glucose, lipids, and amino acid metabolism TG MAL ME1 MTOR HEL-S-26 PMC8901678__F2 Systemic iron homeostasis IBRDC1 SLC39A14 EPO PMC8901678__F3 Iron metabolism in the liver TF BMPR2 STAT3 SLC25A37 FBXL5 IBRDC1 SLC39A14 ACVR2A TFR2 MON1A SMAD4 EPO IL6 HFE2 ERFE BMP6 FTL STEAP3 HFE TMPRSS6 PMC4518307__F5 Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst MAX SLC3A2 GOT2 SLC6A13 ENO2 HK3 SLC25A10 SLC6A12 F2 PGM2 L2HGDH HEL-S-32 PFKL PMC8037590__F1 PI3K and MAPK signalling pathways RPS6 BAX BAD PTEN MTOR DEPTOR EIF4E RHEB TSC2 RICTOR TSC1 MLL2 MDM2 GRB2 PMC8037590__F2 Insulin-mediated feedback loops following PI3K/mTOR inhibition RPS6 PTEN GRB2 MTOR DEPTOR EIF4E PMC8387356__F1 Influence of diets on metabolites and the epigenetic machinery OGA OGT PRC1 PHF6 PMC2804114__F1 IR and IGF family signaling pathway RHEB TSC2 MTOR PMC7696079__F2 Underlying mechanisms of LND-mediated antitumor activity SDHD BAX SDHA SDHC HEL-75 PMC6888321__F3 Cell signaling pathways activated in osteogenesis and angiogenesis models: Wingless-related integration site (Wnt) pathway, bone morphogenetic protein (BMP) pathway, and fibroblast growth factor (FGF)/platelet-derived growth factor (PDGF) pathway SMAD1 DKFZp781O1323 SCUBE3 RUNX2 CTNNB1 PMC6748367__F6 KEGG Pathview readouts of DEX vs Control-associated differential gene expression PIK3CA EGFR APC ERBB2 PMC8633576__F13 Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3B Pathway and Activating Autophagy in Gastric Cancer CDC2 BAX GSK3B PARP1 PMC6468357__F4 FOXK2 role as an oncogene in cancer SOX9 FOXK2 AGA CCND1 CTNNB1 PMC8640960__F3 Molecular Characterization of Limited Ulcerative Colitis Reveals Novel Biology and Predictors of Disease Extension SOCS1 STAT3 TGFBI UGT1A5 OSM LRAT SLC17A8 SLC39A5 SLC39A2 IL33 HOXA6 UGT2B10 TAP1 SLC6A19 SOCS3 SLC30A8 CCL2 DHDH SERPINB8 MAOA SLC22A4 IFNG SLC22A5 ADH1A SLC30A10 HEL-S-18 SULT1A1 HOXC9 SLC17A1 NKX2-2 SULT1A2 GLYATL3 MT1G SLC4A10 HS3ST6 EVX2 ISX CYP27A1 TRPV6 HOXD9 UGT1A1 SLC26A3 TNFAIP6 TNFRSF12A IFITM2 MMP10 IL1A CXCL10 LOXL2 HSD3B1 HOXA4 SULT2A1 MT1E CXCL9 TNLG5A VEGFC THY1 SLC46A1 CYP4B1 CSF3 CSF3R ISG20 IL1B ENPP3 HSD17B3 MT3 KYNU HOXC6 IL6 SLC5A7 KRAS PITX2 HOXD10 SLC5A12 HOXD12 HOXD11 CYP3A4 IL23A SELP PMC10740672__F10 Oncogenic signaling pathway plays a crucial role in tumor suppression in vivo ATR ATM MDM2 PMC12220104__F2 Activation of the IL-11 autocrine loop: TGFB acts on the TGFB receptor on the cell membrane, phosphorylating Smad2/3 in the cytoplasm STAT3 CXCL5 SMAD2 CXCL1 GSK3B ATF2 MTOR CXCL6 IL11RA CCL20 CTNNB1 PMC3820452__F4 Working model for the proliferative, prosurvival, and migratory roles of TRPM8 in pancreatic adenocarcinoma cells EGF CAD EGFR TRPM8 PMC3820452__F2 Working model for the signaling mechanisms that mediate the cellular functions of TRPM7 in pancreatic adenocarcinoma HEL164 STAT3 EGF TRPM7 EGFR SOCS3 PMC2838317__F8 Differences between TRAIL- and AD5-10-induced signaling pathways FADD PMC12003952__F1 PLEVPs hydrogel alleviates psoriasis by modulating the IL-17 signaling pathway PDC FOXP3 PMC4251736__F4 Disorders of the PI3K-AKT-PTEN pathway PIK3CA AKT3 PIK3R2 PIK3R1 PTEN PMC9320947__F1 Contemporary Concise Review 2021: Interstitial lung disease MMP7 ACTA2 COL1A1 NOTCH3 PMC2832838__F1 CONVERTING HUMAN PLURIPOTENT STEM CELLS INTO BETA CELLS: RECENT ADVANCES AND FUTURE CHALLENGES SOX17 EGF PDX1 NR2A1 SOX9 MAFA PTF1A NODAL FOXA2 CXCR4 PMC7716236__F3 Metabolic variations in the course of NB4 differentiation along the myeloid lineage after treatment with ATRA CTRL SDHA NDUFB6 PGAM1 HEL-S-133P HEL-S-162eP LDHB DAP HEL-S-87p PMC10532319__F7 Isolinderalactone Induces Apoptosis, Autophagy, Cell Cycle Arrest and MAPK Activation through ROS–Mediated Signaling in Colorectal Cancer Cell Lines CASP9 CASP3 CDK2 CCNA2 PMC7166192__F3 Process of ferroptosis SLC11A2 TFRC SLC40A1 AIFM2 GPX4 LPCAT3 FACL4 PMC11481463__F1 Critical role of IET as a drug precursor and the metabolic pathways relating to IET biosynthesis in S tal-1 ADH5 PMC8039950__F3 Function and underlying mechanisms of sialylated IgG (s-IgG) in myeloid and B cells CD40 CD80 CSF1 BCR IL33 ELL TLR9 TLR8 CD22 TLR7 PMC6977602__F5 FSS regulating osteoclasts bone resorption function via ERK5 signaling pathway (green arrows are positively adjusted; red arrows are negatively adjusted; red lines are decreased due to inhibition of upstream proteins) CTSK NFATC1 MMP9 PMC3181038__F1 Signaling the unfolded protein response: Three proximal sensors IRE1, PERK, and ATF6 regulate the UPR through their respective signaling cascades ATF4 XBP1 PMC8124588__F1 Anaphylaxis: Focus on Transcription Factor Activity STAT3 GATA2 TSLP GATA1 MRGPRX2 TFEB KIT GATA3 PMC6628023__F5 Schematic illustration of the molecular pathway of AhR and its effects on FSHR and survival AHR FSHR PMC2766922__F2 Signaling pathways downstream of HVEM, LIGHT, and their binding partners are shown BCR CD160 BTLA TRAF3 GRB2 TRAF2 PMC3185585__F1 Remodeling the cellular secretory pathway to support enterovirus replication GBF1 ART1 ARF1 PMC3057180__F1 Backup DNA repair pathway POLM BRCA1 SSB PMC2840158__F6 Schematic showing cytoplasmic signaling pathway from ATM to TSC2 via LKB1 and AMPK to repress mTORC1 and induce autophagy TSC2 ATM MTOR PMC3431500__F1 Class I PI3K signal transduction pathway RHEB TSC2 TSC1 PTEN PMC4369255__F1 Synthesis and mechanisms of gaseous neurotransmitters in the relaxation of penile or other vascular tissues RHO PMC3414739__F2 LECA Rabs and their proposed functions RAB24 RAB14 RAB28 RAB32 RAB18 RAB23 RAB21 PMC7652848__F2 Aryl hydrocarbon receptor (AhR) signaling pathway and tryptophan-indoleamine 2,3-dioxygenase (IDO)-AhR axis AIP AHR PMC4130149__F1 An integrative overview of intracellular signaling pathways by the IL-1R, TLRs, NLRs, and CLRs upon an innate immune response to microbial infection or cell death SYK RIPK2 NLRP3 IL16 TLR4 MYD88 PMC4130149__F4 Schematic overview of TNF-Alpha-induced signaling pathways to activation of NFKB (a), apoptosis (b), and necroptosis (c) RIPK3 TRADD MLKL RIPK1 FADD PMC5316486__F3 Transposon mutagenesis identifies candidate genes that cooperate with loss of Transforming Growth Factor-beta signaling in mouse intestinal neoplasms RAF1 BMPR1A SMAD2 GSK3B PIK3R1 SMAD4 PTEN NEDD9 LATS1 PIK3C2B ACVR1B YWHAQ PDPK1 ITGA6 HEL-S-1 CSNK1A1 HEL2 BMPR2 ACVR2A ILKAP CSNK1D APC LRP5 LRP6 PPP2R1A RAC1 AXIN2 SKI YAP1 CD44 TCF3 ITGB1 CREBBP EP300 GRB2 RRAS2 YWHAZ PMC2933269__F1 Activin signaling regulates transcription of the FSHB gene SMAD4 FSHB PMC7679954__F1 Signaling pathway of NOD1/2 and most TLRs are interconnected through complex pathways JUN NOD2 NOD1 PMC3057180__F2 Exploiting synthetic lethal interactions for the treatment of human cancer ATR ATM GIP PMC2798273__F1 Role of CobT in the late steps of AdoCbl biosynthesis APP NDP PMC5527962__F4 Cell adhesion pathway and ECM–receptor interaction pathways are affected by RCT CD44 JAM2 ESAM CD36 NPNT CHAD CD47 CD99 PMC4334071__F2 Insulin signaling in ovarian thecal cells and proposed mechanisms for selective insulin resistance RAF1 CYP11A1 GRB2 MTOR SHE PMC5527962__F5 Leukocyte transendothelial migration pathway is affected by RCT TEC JAM2 ITGAM VASP ITGA4 THY1 VCAM1 ARHA CXCR4 JAM3 CD99 PMC1869627__F2 Pathway diagram developed using the Ingenuity Pathways Analysis and Knowledge Base in which all genes changed by more than 1.5 fold were queried HEL-S-101 TNC CAST S100A6 S100A8 ADAMTS3 CAPN3 HEL70 GFAP TTN AHNAK RDX S100B PMC3060494__F6 RPA/9-1-1- and hMSH2-mediated ATR activation in DNA damage signaling MSH6 TOPBP1 ATR ATRIP MSH2 PMC5880504__F8 Proposed pathway regulating cultured primary mouse hepatocyte levels of ECs: impact of phytocannabinoids (Δ9-THC), 2-AG, and Fabp1 gene ablation ALB FABP1 FAAH PMC4728196__F1 PI3K pathway with respective PI3K inhibitors TSC2 BAD PTEN MDM2 MTOR PMC6831867__F1 Reactive oxygen species (ROS) metabolism NOX5 NOX3 DUOX1 DUOX2 NOX4 HEL-S-44 PMC6831867__F2 Metabolic interplay between various ROS generators NOX4 HEL-S-44 PMC4264123__F1 Hypothetical diagram of LPS-triggered inflammation and apoptosis pathways summarized in A TBK1 HEL-S-62p CD14 IRF3 IRF7 TRAF3 TRAF6 LBP FADD MYD88 PMC5220130__F7 Schematic representation of the BCR signaling pathway demonstrating the ibrutinib sensitivity of BTK C481 variants and their impact on downstream signaling BCR PLCG2 SRC PMC3714559__F1 Model for resolving transcription-blocking lesions XPA UVSSA PMC6549003__F6 Proposed model for an auto-regulatory feedback loop between the miR-17-92 cluster and the Wnt/Beta-catenin/LEF1 signaling pathway FRZB FZD4 APC LEF1 CTNNB1 PMC3310826__F16 Schematic showing alterations to the TAG biosynthesis pathway in AS11 when DGAT1 activity is absent LPA DGAT1 LPCAT2 PC PMC9340544__F5 Heme Biosynthetic Gene Expression Analysis With dPCR in Erythropoietic Protoporphyria Patients HMBS CPOX ALAS1 ALAS2 FECH UROD UROS PMC8452481__F3 The nervous system in pancreatic cancer KLF4 STAT3 EGFR ASAP1 NTRK3 MTOR MYC GNAS RB1 ALK SRC HSP90AB1 CDH2 MMP7 ROS1 TNK2 RRM1 NGFR RRM2 NTRK2 MMP9 PARP1 CD44 HEL-S-125m NFKBIA ERBB2 RET CP PMC3194983__F1 Inhibition of the type I interferon (IFN) induction and signaling pathways by viral proteins of KSHV TBK1 STAT1 TLR3 STAT2 KY IFNAR2 TLR4 IFNAR1 MX1 JAK1 TYK2 PMC3712028__F7 Model for the mechanism of regulation of glucose metabolism in muscle and liver by leptin in the VMH STAT3 POMC ARC PMC11593954__F5 Comparison of neuro-regeneration mechanisms in the peripheral and central nervous systems CDH2 CNTF SHH RHO MTOR BDNF CTNNB1 PMC11661762__F2 Key enzymes of glucose metabolism (gluconeogenesis, green arrows), DNL (blue arrows), and FAO (orange arrows) are activated by TH (in red) UCP2 PDK4 FASN HEL-S-5 PMC4544784__F5 MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis TH CD2 CD36 ELL CD7 CD14 CD22 EPO CD19 TNF CD34 CD44 CD24 EPOR CD9 CD33 TPO CD6 PMC3906548__F1 AT2R-mediated molecular pathways involved in tissue injury FAS BDNF PMC3771549__F1 Role of Nox-derived ROS in Ang II-mediated effects in vascular cells ARHA PMC10138623__F6 TLR4–RAGE crosstalk participates in the HG-enhanced LPS-induced inflammation in BAMs (created with BioRender HMGB1 TLR4 S100A8 MYD88 PMC6562791__F1 Interconnected pathways of non-essential amino acids (NEAA) metabolism ASS1 ASL GLS PHGDH SHMT1 BCAT1 PSAT1 PAH ASNS HEL-S-51e PRODH PSPH PMC8964769__F6 Publisher Correction: Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway STAT3 HMFT1766 ENG SMAD1 DKFZp781O1323 SMAD4 ANGPT2 PMC9248037__F3 Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer NR2A1 GSK3B SULT1E1 PMC9098828__F1 Updated Understanding of the Crosstalk Between Glucose/Insulin and Cholesterol Metabolism PCSK9 HMGCR LDLR PMC4161047__F1 Pathways implicated in type I IFN production following L CGAS MAVS NOD2 DDX41 IRF3 NOD1 PMC2267731__F2 BL module: A network visualization of the top 25 scoring genes in BL BAX MYB TANK POU2F1 PMC4617137__F1 Anabolic pathway of renal sulfatides CERS3 CERS5 ELOVL2 UGCG FA2H SMS CERS1 CERS2 ELOVL1 ELOVL5 CERS6 ELOVL4 ELOVL3 ELOVL6 PMC8733402__F1 Longevity Factor FOXO3: A Key Regulator in Aging-Related Vascular Diseases IGF1 INSR FOXO3A PTEN MTOR INS PMC7568723__F6 Histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis VAV3 LIMK2 ROCK1 PFN2 RHO PMC9167587__F6 Proposed pathway of quercetin in preventing CKD SMAD2 SMAD4 PMC9678516__F9 Exploring the mechanism of Tengli Kangliu Decoction in the prevention and treatment of colorectal cancer precancerous based on network pharmacology PPARG HPSE PGR EGFR CYCS NR1C2 ACACA RHO CCNA2 MYC CCL2 RUNX2 MPO PRKCB BCL2L1 PLAT F2 F3 CHEK2 CHUK CRP BAX NOS2 JUN E2F2 SELE HK2 PTPN1 IRF1 TNF IGF2 FOS NR3C1 NR3C2 CTSO RELA IKBKB EDNRA APOB CDK2 BCL2 CYP3A4 PMC8021797__F2 Schematic presentation of the STAT1 signaling pathway STAT3 STAT1 IFNGR2 IFNGR1 STAT2 IFNAR2 IFNAR1 TYK2 PMC6571146__F8 Model depicting the potential involvement of the Mek/ERK1/2-MAPK and the PI3K/Akt/mTOR signaling pathways at different stages of developmental myelination and during adulthood RHEB TSC2 TSC1 MTOR PMC8347825__F2 Targeting DNA Damage Response and Repair to Enhance Therapeutic Index in Cisplatin-Based Cancer Treatment ERCC1 MSH2 PMS2 BRCA1 XPC PMC8542838__F3 An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities USP44 OTUD4 TBK1 CGAS MAVS IRF3 IRF7 USP49 OTUD3 IFNAR2 USP18 USP22 USP20 OTUB2 TYK2 CYLD PMC6787451__F6 Effects of ASA in SK‐N‐SH (N) cells TH PRB1 CDK2 CDK4 PMC3392816__F5 Model for inhibitory effect of extracellular nicotinamide phosphoribosyltransferase on insulin-like growth factor-1 function in chondrocytes IGF1 IGF1R IRS1 PMC8380002__F6 Glucose metabolic crosstalk and regulation in brain function and diseases RHEB TSC2 TSC1 WNT3A GSK3B LRP6 HIF1A PMC7072213__F2 Biogenesis mechanism of (a) exosomes and (b) MV, and their release processes which are coordinated through two different intracellular pathways, such as exosomes generation pathway and lysosomal degradation pathway RAB27A RAB27B SDCBP RAB35 PMC8532910__F1 Preclinical Evidence for the Interplay between Oxidative Stress and RIP1-Dependent Cell Death in Neurodegeneration: State of the Art and Possible Therapeutic Implications FAS TRADD MLKL TNF CYLD FADD PMC8558079__F7 Signal Transduction and Molecular Regulation in Fatty Liver Disease LATS1 MOB1A AMOT ARHA NF2 VGLL4 PMC9684170__F3 Hypersensitivity reactions to small molecule drugs C6 STAT3 C7 HEL-S-62p C2 C1S C1R MRGPRX2 C9 CS C4B_2 PMC7352703__F4 Enrichment Kyoto Encyclopaedia of Genes and Genomes (KEGG) analysis of DEGs engaged in the Notch signaling pathway ATXN1L ATXN1 CREBBP NUMB EP300 HES1 HES5 PMC9498168__F6A MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway SCN8A DMP1 NR4A3 SIX4 SOX6 PDE1C SOX4 PIM2 NHS PRDM1 IL1A FOS GRIK3 DUSP19 MYOM2 MTBP UPK1A TIAM1 HEL32 EPM2A SPINK7 ZNF99 HEL110 ABCC9 ERMN MAPK10 DYNAP AKAP12 SLC9A4 TXLNB ERP27 FBN3 ABHD1 PLN TMEM74 KLF2 GRIA2 CLEC3A SLITRK3 KCNN3 SMLR1 ATP2B4 MYEF2 SYT14 CLSPN MPP7 RAG2 E2F7 MZT1 IL2RA MC2R PI15 GPR19 GRID2 GINS4 CASR MGA PIG59 RIPK2 SYNM HEL-S-117 CADM2 MAL SOX2 RGMB CADPS DSG3 SFRP1 RBL1 CCDC17 BYSL ABCG5 SDR9C7 RGS4 PMC3856587__F2 Genetic pathway predicted to regulate the interaction between 5-HT synthesis, transport and degradation and the stress response mediated by the HPA axis CRH BDNF PMC10935043__F7 Diagram picturing two alternative pathways of sorting damaged mitochondrial components into mitochondrial-derived vesicles PINK1 PARK2 SNX9 PMC4474670__F3 Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity CDC42 EHD2 EHD3 EGF CHMP6 VPS25 ARF6 LDLR ARHA CHMP3 VPS36 VPS28 PMC3856587__F3 Simplified model of the regulatory interactions between the serotonin and stress response pathways mediated by the HPA axis SLC18A2 CRH BDNF MAOA AVP PMC3087601__F1 Cellular and bacterial profiles associated with oral epithelium-microbiota interactions ATR CDK7 PCNA CDC45 CDC6 SMAD4 CDK2 ATM MDM2 MYT1 SKP2 PMC8855827__F5 Integrative OMICS Data-Driven Procedure Using a Derivatized Meta-Analysis Approach MAPK1 STAT3 HGF PTK6 STAT2 EGFR HTR2A SOCS3 MAPK3 STAP2 STAT5B NTRK1 STAT4 JAK1 NFKBIZ PMC4474670__F6 Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity RGS14 CAD SP1 LAT RHO PMC4474670__F7 Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity MT3 XRN1 CNOT4 CNOT2 DIS3 DIS3L LSM1 LSM3 EDC3 PAN2 EDC4 CNOT3 LSM8 PAN3 RQCD1 CCR4 DCPS LSM4 LSM2 CA14 PMC5994424__F8 ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1 EGF ADM IL4 ARG1 LAMTOR1 VEGFA PMC7510352__F1 Families of PDGF/PDGFR and the downstream signalling pathways STAT3 PDGFD BCL2L1 SMAD1 BAD PDGFC MMP2 GRB2 VEGFA MYC PMC4488003__F6 The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core BAX MB MTOR PMC8651070__F2 Mechanisms Regulating HLA Class-I Antigen Processing Machinery Component Expression in Cancer Cells LTB NBR1 TBK1 STAT1 CGAS TRAF5 IRF1 IRF3 IRF7 TRAF3 JAK1 TRAF2 PMC5983187__F4 Intracellular signaling pathways arising from B common (Bc) receptor activation AK2 LYN JAK1 PMC10796104__F1 Mechanisms of Janus Kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) in chronic pain STAT3 IL33 SOCS3 CCL2 PMC8684694__F7 Glaucocalyxin A suppresses multiple myeloma progression in vitro and in vivo through inhibiting the activation of STAT3 signaling pathway STAT3 GLA IL6 PMC7649190__F2 Hypothesis that vascular endothelial growth factor (VEGF) may promote T cell exhaustion and therefore Demodex proliferation, by analogy with what happens with tumors TSLP LAG3 PMC7202399__F2 FOXO1 protein activation FOXO1 PTGER4 GPX3 NOX4 PMC8122057__F4 Interleukin (IL)-4 signaling sources (A) and targets (B) AID GATA3 PMC3797768__F4 An Integrated Approach Based on Multiplexed Protein Array and iTRAQ Labeling for In-Depth Identification of Pathways Associated to IVF Outcome CRP TF TH SERPING1 PLG HRG IL4 HAMP HEL-S-92n MBL2 APOH FGA LBP PMC7865468__F1 TGFB in Cancer: Metabolic Driver of the Tolerogenic Crosstalk in the Tumor Microenvironment HEL-S-133P SMAD2 GCLC FBP1 SLC27A2 ARHA GRB2 MTOR HEL-S-26 PMC2880454__F1 Targeting the cancer kinome through polypharmacology INSR EGFR KRAS PMC6219450__F3 DSB-free recombination-dependent replication.A RAD52 RAD51 MRE11A DNA2 WRN BRCA2 PMC8979166__F2 Why Does Piscirickettsia salmonis Break the Immunological Paradigm in Farmed Salmon? Biological Context to Understand the Relative Control of Piscirickettsiosis CXCR1 CD37 APC C9 CD22 STAT4 CD200 PMC9315303__F7 Genistein promotes M1 macrophage apoptosis and reduces inflammatory response by disrupting miR-21/TIPE2 pathway TLR4 VMP1 MYD88 PMC5408670__F1 Tumor necrosis factorA (TNF)/TNF receptor (TNFR)-mediated cell signaling TRADD TNF TRAF2 FADD PMC1502453__F5 Hoxc8-regulated transcriptional network in vivo CD44 EGF SMAD1 CDH11 EGFR SMAD6 SMAD4 HOXC8 CTNNB1 PMC9031059__F3 Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity MRC1 NAB2 GGA1 RCN2 MED13 PMC11846535__F4 Diagrammatic summary of therapeutic strategies and agents (light purple) targeting the TGFB signaling pathway SMAD2 SMAD4 PMC10443056__F1 Different interventions enhance nerve regeneration for the treatment of AD ACHE NGF MSC BDNF PMC2649302__F2 Wnt/-catenin signaling pathway APC GSK3B LRP6 CTNNB1 PMC2649302__F3 Conversations between Wnt/Beta-catenin and MAPK signaling pathways CDC42 RAF1 APC GSK3B LRP6 ARHA RAC1 CTNNB1 PMC3586749__F4 Epithelial to Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma EGF EGFR SMAD2 DSG2 MMP9 PMC2809778__F2 Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, Parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis HTRA2 TFAM PINK1 POLG POLRMT PMC9454636__F1 Drosophila as a Model for Human Viral Neuroinfections TBK1 CGAS TRADD TAB3 IRAK1 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 RELN MYD88 MAP3K7IP1 TRAF2 FADD PMC11846535__F1 This figure illustrates Canonical (SMAD dependent) and Non-canonical (SMAD independent) TGFB signaling pathways TGFBR2 SMAD2 RHO MTOR TGFBR1 PMC9454636__F2 Drosophila as a Model for Human Viral Neuroinfections AGO2 IRF3 IRF7 PMC11846535__F2 Exploring TGFB Signaling in Cancer Progression: Prospects and Therapeutic Strategies EGF HGF APC PTCH1 SMO MTOR PMC6707713__F4 Interplay between DNA tumor viruses and the host DNA damage response BRCA1 RNF168 H2AX ATM PMC8136133__F11 Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer GUCY2D NPPC PDE6G NOS2 GUCA1B GUCA1A GUCA1C PDE11A GUCY2F HEL-S-7a KCNMB3 KCNMB4 PDE5A MTNR1B GNAL CS MAPK14 GNAS PDE1A NPPA GUCY1A2 POU2F1 NPR2 GIPR PMC3924201__F4 Two mechanisms for growth-factor-mediated regulation of the Hippo pathway: activation of Ras-MAPK signaling and activation of PI3K-PDK1 signaling LPA EGF AJUBA PMC3924201__F1 Control of the core Hippo signaling pathway through interacting upstream modules LATS1 LATS2 PATJ AMOT SCRIB NF2 WTIP AREG PMC3924201__F2 Hippo pathway-mediated regulation of cell lineage and pluripotency by adhesion and epithelial polarization in the early mouse embryo LATS1 CDX2 LATS2 AMOT NF2 PMC6481737__F9 Working model of stiffness-dependent calcium response for neutrophils on HUVECs CD44 SYK SRC PMC9450835__F10 Summary illustration of the phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway for rapid lysosomal repair OSBP VAPA PI4K2A PMC7449905__F4 PAK1 is a key molecular determinant in major cell proliferation pathways EGF JUN PAK1 EGFR MTOR MYC LEF1 RAC1 CTNNB1 PMC7449905__F7 PAK1 in autophagy pathways ATG101 ATG12 PAK1 ULK1 FOXO3A SQSTM1 MTOR ATG5 PMC7449905__F9 Crosstalk between PAK1 and other cancer-related pathways TEAD2 TEAD3 PAK1 MTOR TEAD4 PMC6616108__F1 Processing of CD8 ppCT T-cell epitopes TAP1 B2M TAP2 PMC8356873__F1 Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma KEAP1 NQO1 MAF PMC10310781__F1 Amyloid Beta-based therapy for Alzheimer’s disease: challenges, successes and future BACE1 APP BACE2 PMC3858858__F4 Overall PI3K and MAPK-Erk signaling is complex, but can highly influence the balance between cell survival and death BAX BAD PTEN MTOR PMC3690105__F1 Metabolic pathway of clopidogrel CYP2B6 CYP2C19 CYP2C9 PMC8989865__F7 TGFB activates NLRP3 inflammasome by an autocrine production of TGFB in LX-2 human hepatic stellate cells NLRP3 IL18 NOX4 PMC3837249__F1 Toll-like receptor signaling in liver cells TIRAP MAL TLR9 IRAK1 IRF3 IRF7 TRAF6 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC11012292__F1 Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet ACHE PEMT ChAT HEL-S-61p PMC2678983__F4 IFN-gamma signaling pathway STAT1 IRF9 ATF2 DAO FANCC PMC10383978__F3 Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer ME2 PC ME1 PMC7168569__F1 Regulatory roles and underlying mechanisms of ELA-APJ axis in heart failure BAX TGFB1 MMP9 GATA4 PMC4568774__F1 Anti-tumor mechanism of combi-targeting molecule ERCC1 BAX EGF BAD TGFA RAF1 EGFR PMC7990776__F2 BRD4 in innate immunity BRD4 HMGB1 TBK1 CGAS IRF3 IL6 TNF IKBKG MYD88 TLR1 GSDMD NLRP3 TLR3 CASP5 CASP4 RELA IKBKB IL18 NFKBIA CHUK MITA CDK9 IL1B PMC4875828__F1 Mechanobiology of TGFB Signaling in the Skeleton SMAD1 DKFZp781O1323 SOX9 SMAD2 ARHA RUNX2 PMC5260935__F7 Late-phase synthesis of IKBA insulates the TLR4-activated canonical NFKB pathway from noncanonical NFKB signaling in macrophages TLR4 RELA NFKBIA PMC8584326__F1 Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering BIN2 BAK1 PMC9370360__F4 Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases ELF2 APP EIF2A PMC6533689__F2 Telomerase regulation and telomere elongation pathway STAT3 POLI TERT TEP1 PMC3882437__F4 Perturbed pattern of genes in the peroxisome proliferation activator receptor (PPAR) signaling pathway by DEX administration (ethanol plus DEX vs LPL UBC UCP1 HEL-S-28 ME1 CPT2 PMC4055569__F8 Augmenting Microarray Data with Literature-Based Knowledge to Enhance Gene Regulatory Network Inference TP73 STAT3 BAX EGF JUN PCNA FASN PTEN MTOR FOXN3 TNF CRK CCNG1 CDK2 ATM MDM2 BCL6 BIK PMC6906806__F10 The summary of the signaling pathway of TRPC3 upregulation in fibroblasts involved in fibrosis SMAD2 ARHA TRPC3 PMC10843903__F6 Increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study SYK TSC2 BAD BCR EBP RBL2 CD19 PTEN EIF4E PMC10525672__F3 Stress Urinary Incontinence: An Unsolved Clinical Challenge SMAD2 SMAD4 TGFBR1 PMC8533529__F2 Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution NNMT SARM1 NAMPT PMC7698658__F5 Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds CENPF BUB1B CCL3 CENPE AREG IL6 FOXM1 BIRC5 EZR IL16 AURKB CDC45 TLR7 KIN TRAF2 PMC3942883__F1 Induction and clearance strategies PTEN MB TEF PMC9066095__F3 New insights into checkpoint inhibitor immunotherapy and its combined therapies in hepatocellular carcinoma: from mechanisms to clinical trials WNT3A CTNNB1 PMC4591923__F1 Peptide vaccines and peptidomimetics targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy TGFA EGFR KDR GRB2 MTOR VEGFA PMC4231819__F1 Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential CD14 IRF3 TRAF6 IL1B MYD88 PMC6928879__F1 AHR-dependent signaling pathways EGFR AHR PMC6299603__F2 Adipocytokines mediate pancreatic cancer tumorigenesis by different signaling mechanisms STAT3 HEY2 MTOR SIRT1 PMC10957538__F1 Impact of particulate air pollution on airway injury and epithelial plasticity; underlying mechanisms NLRP3 MUC5B IL6 IL1B PMC6299603__F3 Altered gut microbiota is responsible for pancreatic cancer progression CD14 MTOR MYD88 PMC9290708__F1 Review article: therapeutic aspects of bile acid signalling in the gut‐liver axis FGF8A CYP27B1 CYP8B1 CYP7A1 FGFR4 CYP27A1 PMC5359376__F5 Enrichment analysis for pathway map ontologies revealed significant biological processes associated with the most promising targets commonly deregulated in mouse and human ALS EGF ELL PMC6700737__F1 MiR-126-orchestrated regulation of pDC effector functions in lymph nodes undergoing an immune response TSC2 TSC1 PDC TLR9 IRF7 MTOR MYD88 PMC9290708__F3 Review article: therapeutic aspects of bile acid signalling in the gut‐liver axis FGF8A CYP7A1 FGFR4 PMC7963413__F2 Cascade of events triggered by the overexpression of RB1CC1 in SCZ pathogenesis TSC2 TSC1 RB1CC1 PMC12086142__F1 Regulatory mechanisms of NLRP3 inflammasome in PF TGFBI GSDMD PINK1 TGFB1 NLRP3 SMAD2 SMAD4 MYD88 PMC2990064__F4 Modeling Dose-response at Low Dose: A Systems Biology Approach for Ionization Radiation BAX BCL2 PMC4322985__F1 BRAF vs RAS oncogenes: are mutations of the same pathway equal? differential signalling and therapeutic implications EGF EGFR PTEN PMC2891968__F5 Cellular pathways leading to upregulation of COX-2 in neutrophils TLR4 CD14 LBP PMC4850258__F5 Regulatory interactions of Usv101 SP1 UXS1 CIRSR GPR4 PMC2093951__F9 NOVEL VIP SIGNALING PATHWAY IN T CELLS cAMP→ Protein Tyrosine Phosphatase (SHP-2?)→JAK2/STAT4→Th1 differentiation VIP TYK2 IL12RB1 PMC6297758__F7 Involvement of c-myb and E2F1 in the expression and amplification of MYCN GMNN L3MBTL1 PMC6342007__F2 Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases RIPK3 TBK1 TRADD TAB3 RIPK1 OPTN CYLD PELI1 FADD PMC10957538__F2 Epithelial plasticity and impact of particulate matter (PM): Exposure to PM in short term, leads to inhibition of Notch1 by stimulating STAT3 and aryl hydrocarbon receptor (AhR) activation in basal epithelial cells CDH2 STAT3 BRD4 SACS AHR ZEB2 SCGB1A1 PMC10957538__F3 Impact of particulate matter (PM) on airway remodelling CXCL1 IL5 CXCL8 PMC8386127__F11 TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage LPL TREM2 IL10 AXL TLR4 DAP ADAM10 MYD88 PMC3728834__F7 Proposed model illustrating the effects of reduced TH in thyroid cancer development in ThrbPV/PV-PTU mice GSK3B PTEN NR1A2 PMC6478618__F2 Nonalcoholic fatty liver disease-Kyoto Encyclopedia of Genes and Genomes pathway and mechanisms of disease pathogenesis BAX LEP ITCH EBP SOCS3 INS XBP1 RAC1 IRS1 UNKL INSR ATF4 TRAF2 PMC5713364__F7 Analysis of the interconnection between AKAP12 and the merged networks of related joint diseases and functions RENBP ADAMTS2 PMC6602343__F1 Developmental signaling pathway architectures sense, process and control ligands in space and time TF EGF GSK3B SMO CTNNB1 PMC5039030__F8 Model - DPP9 is a negative regulator for Syk signalling, targeting active Syk for degradation by the N-end rule pathway SYK DPP9 CBL BCR FLNA PMC4797178__F5 GeneGO pathway map “Development_TGF-beta-dependent induction of EMT via SMADs” is significantly enriched for genes differentially expressed between MCF-7-Snail and MCF-7-Control cells CDH2 HGF HMGA2 SP1 ID2 SMAD2 SMAD4 HEL-S-28 ARHA PMC2978223__F1 Daphnia pulex insulin and TOR signalling pathways, adapted from Drosophila melanogaster TSC2 TSC1 PTEN PMC4905267__F1 Common vesicular trafficking module in the assembly of the immune synapse and the primary cilium VAMP3 APC IFT20 SMO PMC11204038__F1 Schematic diagram showing the NAD+ metabolic pathway NNMT NMRK1 CYP2E1 NAMPT SIRT1 NMRK2 PMC4117641__F5 TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in ABeta-Expressing Caenorhabditis elegans TCP1 MOB4 CCT8 STK24 PS1TP5BP1 PMC11850097__F11 Action of ZIP8 in macrophage polarisation and IDD TGFA ADAMTS5 PMC7226805__F1 Molecular mechanisms regulating autophagy ATG101 ATG12 ULK1 ATG14 VPS18 PMC4874035__F7 Vascular control of the haematopoietic microenvironment by Slit/Robo signalling CDC42 PMC11241496__F2 Targeted therapies in RAS-RAF-MAPK pathway EGFR PTEN MTOR KRAS RET PMC11241496__F3 Targeted therapies in the vascular endothelial growth factor (VEGF) pathway VEGFB VEGFC PIGF AXL PTEN MTOR VEGFA PMC5962337__F7 Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress AS3MT AQP7 MTF1 AQP9 HEL-S-162eP PMC5713364__F6 Network analysis by Ingenuity®Pathway Analysis (IPA) indicated molecules associated with rheumatic disease and inflammation of joint BDKRB1 PPARG GPC1 KLKB1 CREB5 RGS5 SESN3 PLG KCTD20 ADAMTS12 AKAP12 NOTCH2 PMC5512440__F7 Hepatocyte ABCA1 deletion impairs liver insulin signaling and lipogenesis CD36 LDLR ABCA1 PMC3575813__F10 Presence of a diversity of Alu-mediated events in genes involved in apoptosis BAD FAS TRADD ATM TRAF2 FADD MYD88 PMC7933466__F1 Metabolites regulating nucleic acid sensing pathways TBK1 MAVS TLR3 KEAP1 SUCNR1 IRF3 PMC7819868__F1 REG4 signaling pathway CDX2 CDK6 TGFA ADAM17 GPR37 SP1 EGFR GSK3B CDK4 REG4 CTNNB1 PMC8079368__F4 Molecular mechanism of lateral bud differentiation of Pinus massoniana based on high-throughput sequencing TF BIN2 HEL-S-30 PMC4915362__F3 Converging roles of caspases in inflammasome activation, cell death and innate immunity RIPK3 SYK FAS NLRP3 BCL10 NOD2 RIPK1 TNF IL1B CARD9 FADD MYD88 PMC9468863__F2 Impact of local anesthetics on epigenetics in cancer BTG1 EGFR PTEN MTOR SOX4 PMC4915362__F4 Converging roles of caspases in inflammasome activation, cell death and innate immunity BAX TBK1 CGAS MAVS MLKL IRF3 RIPK3 NLRP3 RIPK1 APAF1 CYLD IL1B FADD PMC10900617__F8 ZnONPs disrupt lysosome activity and impair autophagic flux to facilitate exosome secretion in keratinocytes and macrophages TLR1 NLRP3 TLR3 PMC7468567__F4 Target genes and pathways of COL-3 and CGP-60474 in treating lung injury in COVID-19 CDC42 JUN FAS VASP PFN1 RAB7A MAP3K13 PXN IL2RG RAG2 TNF CCL2 FOS HEL-S-99n BCL2L1 CAPZB WAS HLA-B SNX2 HLA-C HLA-A HEL-S-15 PMC8430223__F2 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases EPHB4 POSTN LRP6 CTLA4 RUNX2 PMC8996945__F2 Prognostic Role and Significance of Dll4 and Toll-like Receptors in Cancer Development JAG2 PMC6509750__F3 Influence of TGFB1 on the balance between the canonical WNT/Beta-catenin signaling and PPARG DKK1 APC LRP5 LRP6 PTEN CTNNB1 PMC8430223__F3 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases POSTN ATF4 EIF2A PMC8430223__F4 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases POSTN NOS2 ADAMTS4 MMP3 MTOR CTNNB1 PMC8430223__F5 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases POSTN NLRP3 TNF IL1B PMC5962337__F1 Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress ATOX1 CCS SCO1 CPO SCO2 COX19 ATP7B COX17 COX11 ATP7A CP PMC7587925__F3 Kupffer Cells TLR4 CD14 TRAF6 TNF LBP MYD88 PMC3606533__F1 Genes in choline/1-carbon metabolism and related pathways influence hepatic lipid balance PNPLA3 APC ABCB4 PEMT CHDH HEL-S-61p SLC44A1 PMC11011430__F5 Signaling pathways upregulated in higher Gleason grade groups NDC1 STAG2 NUP155 THOC2 RAN TICRR NUP214 MAU2 PCNA NMD3 STAG1 SMC3 PHAX SMAD4 SKP2 WAPAL SENP2 MDM2 NUP133 DBF4 NUP85 THOC7 TRIP13 MAL NUP205 POM121 NUP188 NUP62 MAGOH RAD21 MTBP SAP18 THOC6 CDC45 CDK2 NUP54 RNPS1 NIPBL PMC11011430__F6 Analysis of the Gene Networks and Pathways Correlated with Tissue Differentiation in Prostate Cancer TRDN PLN CAV3 HRC BCR PI3 NOG MCU DAO PMC3262916__F2 Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment NR1i1 APC CTNNB1 PMC11204910__F1 Heme biosynthetic pathway in erythroid cells and the role of ATP-binding cassette transporter B7 (ABCB7 gene): The first enzyme of heme synthesis is 5-aminolevulinate synthase (ALAS2), which is the rate-limiting enzyme SLC25A37 NDUFB11 ABCB7 FES ALAS2 HSCB PMC7923230__F6 New Gene Markers Expressed in Porcine Oviductal Epithelial Cells Cultured Primary In Vitro Are Involved in Ontological Groups Representing Physiological Processes of Porcine Oocytes COL1A2 UNC45B VLDLR THY1 TXNIP CELA1 SLC5A1 SGCE ITGB3 LIPG NOX4 LOX IDO1 CRABP2 FST SERPINB2 PMC7923230__F2 ‘Signaling pathways regulating pluripotency of stem cells’ KEGG pathway STAT3 JUN REST LIF APC DUSP9 SOX2 SMAD4 NODAL ISL1 NOG BMP4 HES1 PMC3984709__F9 Schematic diagram of the proposed interface between mechanostimulation and biological signaling at acupoint PANX1 TRPV1 PMC9681895__F3 Effect of maternal body mass index on the steroid profile in women with gestational diabetes mellitus CYP17A1 CYP11A1 PMC9172006__F3 TMEM16A as a potential treatment target for head and neck cancer STAT3 EGF EGFR SRC PMC8590447__F12 SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein MIF NOTCH3 ACE2 PMC4721683__F4 Signaling pathways related to the activity of oxaliplatin and 5-FU for colon cancer cell lines NF1 EGFR SMAD2 APC JAK3 GSK3B AXIN1 SMAD4 MTOR CTNNB1 TGFBR1 PMC2556095__F6 In the canonical TGFB signalling pathway, ligands signal through type I and II transmembrane protein kinase receptors TF IRF6 TGFB1 SMAD2 SMAD4 OVOL1 PMC2556095__F4 TGFBeta-related signalling pathway controlling Myc activity in keratinocytes E2F4 MYC OVOL1 PMC9661392__F8 Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway CDH2 BAX TMEM100 SCNN1D CCND1 PMC6700476__F1 Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells BMP4 SOX2 TBXT MTOR MIXL1 PMC11074473__F3 M5C methylation in innate immunity (By figdraw NSUN2 CGAS MAVS GPX4 TLR9 TLR5 IRF3 IRF7 NSUN5 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 ACE2 PMC10813482__F1 DNA modification of MSCs in SONFH MSC FZD1 RUNX2 ABCB1 PMC4885164__F1 Role of stromal cell-derived factor 1A pathway in bone metastatic prostate cancer MSC CXCL16 CXCR4 CD164 PMC6076887__F3 MRN complex activates possible (alternative) pathways at DSBs TOPBP1 ATR ATRIP RAD51 DNA2 BRCA1 RAD17 BRCA2 ATM MDC1 PMC4967105__F3 SKN-1 in the development of C MED1 POP1 CTNNB1 PMC4652017__F2 Putative stress signaling pathway in wheat where functional genomics contribute TF MYB ERF PMC4460069__F1 Comparative Transcriptome Analysis Reveals the Influence of Abscisic Acid on the Metabolism of Pigments, Ascorbic Acid and Folic Acid during Strawberry Fruit Ripening GMPPB IPP SHD DHFR PMVK GGH MVK DHPS PMC5803081__F1 Beyond Alkylating Agents for Gliomas: Quo Vadimus? HK2 MYC HEL-S-26 PMC9270554__F7 Metabolic plasticity in blast crisis-chronic myeloid leukaemia cells under hypoxia reduces the cytotoxic potency of drugs targeting mitochondria ACLY HMGCS1 OGDH HEL-S-133P HEL-S-68p FASN ME1 HEL-S-87p HEL-S-30 HEL-S-64p HEL-75 PMC6155262__F7 CCL19 suppresses angiogenesis through promoting miR-206 and inhibiting Met/ERK/Elk-1/HIF-1A/VEGF-A pathway in colorectal cancer CCL19 CCR7 VEGFA PMC4122337__F2 Potential roles of GPR120 and its agonists in the management of diabetes MAP3K7IP1 NLRP3 IL1B PMC9616595__F1 Intersection of metabolism and inflammation is governed by the intracellular topology of hexokinases and the metabolic fate of glucose HK2 HEL-S-162eP S100A8 SIRT2 S100A9 PMC8151958__F2 GSK-3B in the Regulation of Protein Turnover, Myosin Phenotype, and Oxidative Capacity in Skeletal Muscle under Disuse Conditions TSC2 IGF1 CTNNB1 PMC9293977__F5 Bone remodeling: an operational process ensuring survival and bone mechanical competence EPHB4 EPHB2 MTOR PMC4589110__F4 TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System DTNB MSRA TXNIP PRX PTEN PMC5600869__F3 Passive DNA demethylation pathway DNMT3B PMC5600869__F4 Active DNA demethylation pathway DNMT3B SMUG1 MBD4 TDG PMC11622572__F7 Signaling pathway analysis of genes in cluster 5 using KEGG database (A) Gene expression profile during functional unloading (B) Heatmap of DEGs with p LPL APOC3 ACOX1 EHHADH CD36 FABP1 FABP4 HMGCS1 APOA2 PLIN4 OLR1 ANGPTL4 FABP5 RXRA PLIN1 ACADL PLTP CPT2 SLC27A4 APOA5 PMC5955127__F3 Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells FOXM1 PYGO2 APC GSK3B TCF4 CTNNB1 PMC5343833__F6 Involvement of TGFB/Smad pathway in AA-induced fibrogenesis PMC4197574__F3 Studying ultradian oscillations using optogenetic tools ASCL1 CRY2 MTOR PMC4861305__F1 Decorin induces autophagy in endothelial cells PEG3 MTOR DCN PMC4066640__F5 MYC autorepression and general cellular gene repression by histone modification EZH2 PTEN MYC PMC5009385__F7 Insulin-like growth factor 1 regulates growth of endometrial carcinoma through PI3k signaling pathway IGF2R IGF1 IGF1R CCND1 IGF2 PMC7247696__F1 Toll-like-receptor (TLR)-4, after activation by pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) supported by myeloid differentiation factor-2 (MD-2), initiates downstream signaling in two major ways TIRAP TLR4 IRAK1 IRF3 TRAF3 TRAF6 MYD88 PMC7247696__F2 TLR-4 Signaling vs. Immune Checkpoints, miRNAs Molecules, Cancer Stem Cells, and Wingless-Signaling Interplay in Glioblastoma Multiforme—Future Perspectives DKK3 TBK1 PMC7828596__F1 Canonical aryl-hydrocarbon receptor (AhR) pathway EPHX1 AIP AHR AHRR PMC5503214__F7 Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat CIDEB DGAT1 DGAT2 APOB PMC11806588__F2 The potential pathways and mechanisms of genes associated with skin colour-related phenotypes MC1R CPNE7 ASIP SPG7 DEF8 IRF4 PMC11806588__F3 The potential pathways and mechanisms of genes associated with wrinkling and sagging-related phenotypes PRDM16 SPTLC1 RORA PMC5600869__F1 Schematic diagram for molecular mechanisms of activation of ER stress PI3 ATF4 EIF2A PMC11806588__F4 The potential pathways and mechanisms of genes associated with skin cancer-related phenotypes CLPTM1L TERT LPP PMC9479192__F1 Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies APC GSK3B CTNNB1 PMC3374844__F1 Three major UPR pathways in metazoans ATF4 EIF2A XBP1 PMC9414803__F4 Portulaca oleracea L. Extract Regulates Hepatic Cholesterol Metabolism via the AMPK/MicroRNA-33/34a Pathway in Rats Fed a High-Cholesterol Diet TG ABCG8 CYP7A1 PON1 ABCA1 PMC5470961__F5 Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis BAMBI LMO7 EPX FER INSR SMAD4 ARHA NLK TNF OTP PMC9095829__F10 TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases ADM TRPC5 IL8RB TRPC3 PMC3362997__F10 Competitive displacement of DMP1 by ASARM peptide modulates PHEX–DMP1-mediated FGF23 expression (see central osteoblast in green) TCIRG1 DMP1 FGF23 PMC6292929__F1 CBL0137 exhibits its antitumor activity via multiple pathways CBL HSF1 NOTCH1 PMC9214065__F1 Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell INA APC GSK3B LRP5 LRP6 CTNNB1 PMC6440987__F2 Pool sizes of intracellular metabolites in S HEL60 HEL-S-68p HEL-S-32 ENO1 MDH2 PCK1 HEL-S-26 PMC9268386__F2 Estrogen-Related Receptor A: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis IFNG STAT1 TANK SENP6 MYC PMC9268386__F3 Estrogen-Related Receptor A: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis TGFB1 CCL7 MTOR VEGFA PMC8787094__F1 Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins CGAS MAVS MLKL RNASEL IRF3 MYD88 RIPK3 GSDMD RAF3 ZBP1 NLRP3 TLR3 RNASET2 RO60 TLR8 TLR7 ZNFX1 OAS1 PMC3230308__F1 Autophagy pathway and relationship to mTOR signaling TSC2 TSC1 UVRAG AMBRA1 PML PTEN MTOR PMC3473259__F2 Main pathway disorders leading to muscle proteolysis, atrophy, hypoxia and anti-oxidant response CHFR UBE2G1 GSK3B HIF1A MIF MTOR HEL-S-97n CLN3 CBL ENO3 FOXO1 HEL-S-162eP NDUFA3 CYGB AAG1 AKTIP PFKM PMC2727910__F1 Map of arachidonic acid (AA) cascade LTB LTA COX1 PMC9686921__F6 NADPH Oxidase 5 (NOX5) Overexpression Promotes Endothelial Dysfunction via Cell Apoptosis, Migration, and Metabolic Alterations in Human Brain Microvascular Endothelial Cells (hCMEC/D3) RPL19 RPL35 RPS10 RPL34 RPS5 RPL29 RPL28 WDR55 PMC6414445__F9 Rickettsia conorii and R ACLY VDAC3 MTCH2 SLC25A5 GOT2 FH ACO2 SLC25A3 CS PDHA1 HADHB ME2 SLC25A6 SLC25A1 DLD HEL-S-32 MDH2 TOMM40 HEL-S-26 MST065 PMC9596445__F5 Phenylpropane Metabolic Pathway Illustrates in flavonoids accumulation and lignin synthesis in Populus wilsonii CAD F3 PRX PMC9450349__F5 ASXL1/2 mutations and myeloid malignancies BRD4 BAP1 MTOR PMC7324642__F2 Humoral innate immune signaling pathways SPN REL FADD PMC2330230__F9 Candidate interactors and their putative postion in the Frizzled signaling pathway HDAC1 EGFR APC ARHA CREB1 NOTO PMC12235022__F6 Investigating the Therapeutic Mechanisms of Honeysuckle (China) in Sepsis Through Network Pharmacology and Experimental Validation SOCS1 ZAP70 STAT3 JUND CCK KEAP1 MCL1 GSK3B TLR9 EPO SOCS3 MYC MAPK8 CCL2 CTSC MAPK3 MAPK14 IFNG HSPD1 ADM2 MFN2 POMC MMP3 GHR CALML3 NR1i1 MEFV H4C9 CASP9 NOS2 SIGLEC9 DEFB4B P2RY11 APOE CASP12 APC SNCA IRF3 TNF ANGPT2 SST TSC2 ACTR2 TSLP FZD4 IGF1 CDKN1A PRKACG EDNRA EDNRB BCL2 HLA-B THPO CCL20 AVP HEL-S-103 IL19 CXCL12 LEP CD27 CRH IL2RA TERT ITGAX PLCG1 HLA-DRA TLR4 CNR2 IL18 NOD2 IL31 VWF ARRB2 IL4 CD19 IL17A HEL-S-30 SPP1 NLRX1 MRC1 CXCR1 TLR3 CREBBP EP300 TNFSF10 CALCA PS1TP5BP1 CD40 CD3D PPARG SYK LTA CLEC7A VLDLR PIK3CD IRAK4 HMOX1 TXN CD74 PRKCA APLN CYBA MDM2 VIP RYR2 EDN3 CSF2 ADM TNFSF6 PLG NAMPT AIM2 PTK2B FOS IFNAR2 HSPA4 FGA CCL4 IL8RB BDNF CXCR4 RET TNC ADAR EGF HEL113 COMP BAD FAS PSPN ARTN NRTN HEL-S-62p TAB3 SQSTM1 PTEN ATP2A2 CS MTOR CSF3 NOX4 BTK LY96 ACKR3 IL2 FCGR2A CRP BAX TRPM7 JUN GDNF SELE CD14 BLNK PTPN11 CXCL2 CD44 ITGAM AGER RELA PTH CISH PF4 PMC12235022__F7 Investigating the Therapeutic Mechanisms of Honeysuckle (China) in Sepsis Through Network Pharmacology and Experimental Validation CD40 CD80 TIRAP STAT2 CTSK CD14 IRF3 IRF7 TRAF6 MYD88 TLR4 TYK2 LBP FADD PMC6741895__F7 The FA pathways involved in ABeta-induced neuronal dystrophy CBL CDK5 FYN GSK3B APP PMC5063343__F5 Heat Stress and Lipopolysaccharide Stimulation of Chicken Macrophage-Like Cell Line Activates Expression of Distinct Sets of Genes CD40 CASP9 JUN HSPA14 DNAJA4 TRAF6 HSF2 IFNG LITAF DNAJB6 TLR4 HSPA2 IL18 CASP3 RB1CC1 CCL4 IL12B PMC3234268__F5 Genome Characterization of the Oleaginous Fungus Mortierella alpina ACLY RPE GLYCTK ELOVL2 HEL-S-304 RPIA ACAT2 ACD SMO CDIPT PMC5031209__F2 Apical signals inhibit nuclear YAP localisation EGFR RHO SRC PMC9553898__F8 Possible scheme depicting the role of mTORC1 signaling in estrogen-induced epithelial cell proliferation and differentiation in mouse vagina RPTOR EREG YAP1 PMC5437397__F7 RNA interference (RNAi) pathway members in malacostracans AGO1 AGO2 DERA ME1 DROSHA PMC5010773__F1 Representation of Canonical Wnt/Beta-catenin pathway APC HEL-S-11 RHO MYC CCND1 CTNNB1 PMC7599158__F3 Proposed molecular functions for lncRNAs PICSAR and PRECSIT in cSCC MMP10 EGFR PMC11617869__F2 SSA significantly impacts cancer by inhibiting cell proliferation, inducing apoptosis, suppressing invasion, reducing cell growth, and alleviating skin toxicity BAX BAD EGFR GC MTOR SRC CXCR4 NOX4 PMC321741__F1 Signaling pathways for TLR-3 and TLR-4 TLR3 TLR4 IRF3 PMC4267955__F10 Loss of signaling via GA13 in germinal center B cell-derived lymphoma S1PR2 P2RY8 ARHGEF1 ARHA GNA13 PMC4409298__F7 BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses SMAD1 DKFZp781O1323 CCL2 YAP1 PMC5732027__F5 Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements AGO2 POLI PMC3680431__F7 Acute-Phase Serum Amyloid A in Osteoarthritis: Regulatory Mechanism and Proinflammatory Properties CD36 TLR4 GC IL1B PMC8073961__F2 Role of adiponectin in VSMC MFN2 ARHA IRS1 PMC11654178__F4 Upstream Pathway of Triterpenoid Synthesis in C HMGCR MVD FDPS MVK PMC4424351__F9 The role of UV radiation in the modulation of STING-dependent IRF3 activation TBK1 CGAS ULK1 AMBRA1 IRF3 PMC9676400__F7 Chicken anemia virus VP1 negatively regulates type I interferon via targeting interferon regulatory factor 7 of the DNA-sensing pathway TBK1 CGAS IRF7 PMC3318683__F12 A model of MMP-9 sorting and trafficking in activated macrophages RAB27A CD63 PMC5574206__F1 BMP signalling utilises canonical Smad dependant pathways and non-canonical Smad-independent pathways BAMBI SMURF1 NEDD4 RNF11 PMC8258627__F1 Advances in the role of autophagy in the development of retinoblastoma ATG12 ULK1 TFEB MTOR ATG5 PMC3798270__F6 The Bacterial Response Regulator ArcA Uses a Diverse Binding Site Architecture to Regulate Carbon Oxidation Globally ACHE SDHA HEL-S-5 AIDA PMC7408918__F1 Androgen at supraphysiological level (SAL) induces cellular senescence through the PI3K/Src/Akt/mTOR pathway RAF1 MTOR SRC PMC11594236__F1 Cellular mechanisms involved in OA synovitis in osteoarthritis CCL3 S100A8 CCL5 CCL2 PMC7408918__F2 AR antagonist induces cellular senescence in PCa through the Src/Akt pathway RAF1 SRC PMC11594236__F2 Cells of innate immunity and network of mediators in OA synovitis CD209 STAT1 CD14 GNLY PMC3411967__F1 Cell-proliferative signaling pathways in lung tumors EGF EGFR NRAS PMC6510479__F4 Epigenetic reprogramming of the innate anti-viral interferon response (IFN) RELA IRF1 EZH2 MYD88 PMC3809064__F1 Targeting Mutant Fibroblast Growth Factor Receptors in Cancer CBL FRS2 SOS1 IL1A GRB2 PMC11854957__F1 Transcription Factor CcMYB330 Regulates Capsaicinoid Biosynthesis in Pepper Fruits AMT CS PMC9168780__F12 Emerging roles of cystathionine Beta-synthase in various forms of cancer ACLY SMAD2 SP3 TWIST1 CTNNB1 PMC9192746__F5 Quercetin against atrial fibrillation explored by network pharmacology combined with molecular docking and experimental validation MAX CD14 HELB HP PROC DAO PMC12069211__F9 Construction of “KEGG pathway-target” network CA4 TH MAFK AKR1B10 CDK6 ALOX5 TLR4 HEL-S-11 PDE4D ABCG2 ABCB1 ACHE NOS2 CA13 HSD11B1 CYP1B1 AKR1C1 MMP9 VILL CHRM2 HSD17B2 XDH PTGES REL AKR1C4 PMC4392267__F8 Proposed model for the involvement of TRIP in the TNF-induced inflammatory response CSA2 TRADD SPHK1 IL6 TNF TRAF2 IL1B PMC7746852__F2 Alteration of host signaling pathways by HIV-1 FAS TRADD NLRP3 CCR5 CXCR4 FADD PMC7746852__F3 Insights into the counteraction of host defense by viral protease and Vpu TBK1 PEX7 MAVS IRF3 PEX2 PEX11B CTNNB1 PEX13 PMC9168780__F10 Emerging roles of cystathionine Beta-synthase in various forms of cancer CAMKK2 PTEN MTOR PMC9168780__F11 Emerging roles of cystathionine Beta-synthase in various forms of cancer KEAP1 BCL2 TYMS MTOR PMC3071576__F2 Proof of Concept Trials in Bipolar Disorder and Major Depressive Disorder: A Translational Perspective in the Search for Improved Treatments PSD NACA PMC7290051__F5 Interaction between imaging agents and the blood-brain barrier SLC25A38 HMBS ALB ABCB6 PBR ABCG2 FECH SLC22A6 ABCB10 UROD ABCB1 SLC15A2 PMC8739471__F10 Integrated Pharmacogenetics Analysis of the Three Fangjis Decoctions for Treating Arrhythmias Based on Molecular Network Patterns PLN CAV3 CAV2 HRC BCR PI3 MCU PMC11284386__F1 Systemic and renal iron homeostasis ERFE STAT3 EPO HIF1A PMC9331520__F3 Tumor microenvironment involvement in colorectal cancer progression via Wnt/Beta-catenin pathway: Providing understanding of the complex mechanisms of chemoresistance CXCL12 HGF CTNNB1 PMC9331520__F4 Tumor microenvironment involvement in colorectal cancer progression via Wnt/Beta-catenin pathway: Providing understanding of the complex mechanisms of chemoresistance HGF APC GSK3B CTNNB1 PMC5399110__F9 A schematic representation or summary of the alteration in endothelial cell signaling by aberrant NOSTRIN expression TRADD NOSTRIN TRAF6 PMC10148646__F1 Molecular and Clinical Features of Hepatocellular Carcinoma in Patients with HBV-HDV Infection DNMT3B HEL-S-22 NOX4 CTNNB1 PMC3091517__F2 Ras/PI3K/PTEN/Akt/mTOR Pathway and Potential Sites of Therapeutic Intervention RHEB RPS6 EIF4B PTEN MDM2 GRB2 MTOR SHE DEPTOR PMC3091517__F3 Interactions between the Ras/Raf/MEK/ERK, Ras/PI3K/PTEN/mTOR and Wnt/Beta-Catenin Pathways that Result in the Regulation of Protein Translation and Gene Transcription RHEB TSC2 TSC1 SALL4 PMC3091517__F1 Ras/Raf/MEK/ERK Pathway and Potential Sites of Therapeutic Intervention with Small Molecule Membrane-Permeable Inhibitors RPS6 EIF4B GRB2 EIF4E PMC7149907__F5 Oncogenic seRNA participates in carcinogenic processes through activating various signal-pathway EGFR SOX2 GSK3B TP63 EZH2 ARHA MYC CD47 CTNNB1 PMC8196994__F1 Altered Signal Transduction in the Immune Response to Influenza Virus and S. pneumoniae or S. aureus Co-Infections C6 FH HEL-S-62p C2 C1R C4A PMC9424846__F3 Assessing the suitability of long non-coding RNAs as therapeutic targets and biomarkers in SARS-CoV-2 infection PMC9424846__F4 Assessing the suitability of long non-coding RNAs as therapeutic targets and biomarkers in SARS-CoV-2 infection STAT3 IL17RC TRAF6 IL23R IL1B PMC4102832__F2 Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities H2AX GSK3B LRP6 CTNNB1 PMC10742113__F1 Comparative signaling pathways mediated by adiponectin, leptin and resistin STAT3 ADIPOR1 ADIPOR2 TLR4 LEPR POMC SOCS3 IL6 VCAM1 AgRP PMC7526619__F1 Omega-3 and omega-6 long-chain fatty acids synthesis pathways compete for the same enzymatic machinery in the cell ELOVL4 ELOVL3 ELOVL2 COX1 COX2 C2 ELOVL1 ELOVL5 PMC10242764__F7 Molecular Mechanisms of Notopterygii rhizoma Et Radix for Treating Arrhythmia Based on Network Pharmacology RFWD2 BAX CASP9 ATR AIFM2 PERP CASP3 CDK2 ATM PTEN MDM2 MTOR PMC10742113__F2 Comparative signaling pathways of IL-6, PAI-1 and MCP-1 STAT3 CCR2 SOCS3 PMC3419619__F8 Protein kinase CD (PKCD) activation by proteolytic cleavage downstream of tumor necrosis factor (TNF) signaling in dopaminergic neurons TRADD TRAF2 FADD PMC10242764__F5 Construction of drug-compound-target-pathway network C6 C7 HEL-S-62p C2 C9 PMC6959184__F1 The role of MYD88 signaling in normal physiology and lymphomagenesis STAT3 CD79A BCR PLCG2 IRAK1 IRAK2 MTOR TRAF6 PMC12190641__F1 Study flowchart IGSF3 AMD1 SPTLC2 PMC8599287__F7 USP25 Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Modulating the PI3K/AKT Pathway via Deubiquitinating PTEN USP25 CDC2 PTEN CDK4 PMC8396448__F4 Pathogenesis and Therapeutic Approaches of Diabetic Neuropathy in the Retina STAT3 STAT1 TSC2 TSC1 SGK1 LIF GSK3B PTEN SOCS3 BDNF EIF4E PMC10742113__F5 Bacterial degradation of trimethylamine (TMA) for trimethylamine N-oxide (TMAO) formation NLRP3 IMPACT PMC4425997__F1 The fundamental aspects of the DNA damage response pathway BAX ATR BRCA2 ATM PMC10742113__F3 Signaling pathway mediated by Escherichia coli lipopolysaccharides (LPSs) FAS TLR4 VCAM1 TRAF6 TNF IRS1 MYD88 PMC8396448__F3 Pathogenesis and Therapeutic Approaches of Diabetic Neuropathy in the Retina BAX CASP9 BAD GSDMD CAD SP1 TRADD CASP3 SP2 ATF4 TRAF2 FADD PMC7409273__F7 Proposed model of signaling pathways involved in HPV16 E7-mediated Pirin upregulation in oral epithelial cells EGFR PIR PMC8904921__F5 Green Tea Polyphenols Upregulate the Nrf2 Signaling Pathway and Suppress Oxidative Stress and Inflammation Markers in D-Galactose-Induced Liver Aging in Mice KEAP1 NQO1 MAF TNF PMC3670266__F1 Circulating miRNAs as new activators of the JAK-STAT3 pathway STAT3 SOCS5 IL6 PMC8509312__F6 Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment MAL NNT CIT PMC2823977__F1 REACTIVE OXYGEN SPECIES, CELLULAR REDOX SYSTEMS AND APOPTOSIS BAX FAS TRADD TRAF2 FADD PMC3613593__F1 Hedgehog pathway KIF3A BOC SMO RAB23 GAS1 GLI3 PMC6697777__F7 CaSR-mediated signaling and mesenteric artery relaxation CASR ADRBK1 NPS CYP2J2 PMC8526712__F5 Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy MADD STAT3 IFNGR1 TRADD JAK3 IRAK1 IRAK2 IRAK4 MYD88 IL1R1 STAT1 IFNGR2 IRAK3 MAP3K7 TRAF2 FADD PMC8430856__F2 Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance BAD TRIAP1 PTEN MDM2 PDK2 PMC8430856__F1 Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance BAX TRADD PMC2684550__F2 In MSTN-null mice, regulators of the PI3K pathway and cell survival/apoptosis likely contribute to muscle hypertrophy BIRC5 PINK1 PTEN PMC3855388__F4 CyTargetLinker: A Cytoscape App to Integrate Regulatory Interactions in Network Analysis TEC EREG SHE PMC3787240__F2 Selected non-epigenetic effects of sulforaphane and I3C/DIM on prostate cancer cells BAX CDK6 BCL2 SFN PTEN MTOR PMC5397262__F2 Misregulated expression of members of the ubiquitin cascade contributes to the aberrant signaling of various pathways in cancer TRADD RBCK1 SMAD2 RNF31 SMAD4 UBE2S TNF HEL-117 STUB1 VHL WWP1 SHARPIN UBE2V1 USP15 USP4 SMURF2 PMC9562180__F2 Macrophages, Chronic Inflammation, and Insulin Resistance TRADD TLR4 SOCS3 IL6 TRAF2 IL6R IRS1 MYD88 PMC4670915__F5 Scheme of the metabolic effect in control and differentiated SH-SY5Y cells SIRT3 MDM2 PMC8359344__F2 Multifaceted role of cell cycle regulators in the coordination of growth and metabolism FAS GLS DHFR ELOVL6 SIRT6 PMC8359344__F3 Multifaceted role of cell cycle regulators in the coordination of growth and metabolism CDC2 CDK6 CDK5 RALA TXNIP MFN1 APC CDK2 FLCN CDK4 PMC4591129__F3 Microarray Analysis of the Gene Expression Profile and Lipid Metabolism in Fat-1 Transgenic Cattle LPL UBC AQP7 SCD UCP1 HEL-S-28 PLTP PMC6791268__F2 Oncogenic activity of Bacteroides fragilis and Salmonella enterica STAT3 CXCL5 CXCL1 SMO CXCL2 CTNNB1 PMC10673274__F1 Sites of cellular PPi formation and details of galactose metabolism HEL-S-66p PPA2 PMC7840349__F2 Recent Updates of Lipoprotein(a) and Cardiovascular Disease TEC TFPI PLG PMC8960856__F4 MicroRNAs in Serum Exosomes as Circulating Biomarkers for Postmenopausal Osteoporosis ROCK2 APC SMAD4 RYK ARHA BAMBI SOST INVS CBY1 STOM WAS CER1 SKP1 NLK PMC10914313__F7 The mechanism by which ARM promotes chemoresistance via PPARG/ABCG2 pathway TF CD36 ABCG2 PMC2484121__F2 Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs): Multifunctional proteins in cancer CD44 DMP1 PI3 PTEN PMC11978139__F2 Molecular processes underlying CXCL2 secretion STAT3 FAS TLR4 CXCL2 SOCS3 PMC2725207__F3 Tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1 RFC4 RFC2 RFC3 PMC3197364__F6 Hypothesized mechanisms for sphingolipids in cardioprotective signaling in response to ischemia or hypoxia HEL164 PAK1 TNF SKI PMC11953409__F1 Metabolic pathway shifts in T cells RHEB TSC2 TSC1 APC PMC6283435__F3 TF cascades under glucagon control KLF15 EGR1 TFEB YY1 PMC8574228__F5 Metabolic flexibility and HFpEF LPL CD36 HEL-S-5 SIRT1 PMC8574228__F2 Fibrotic–inflammatory remodelling in heart failure with preserved ejection fraction STAT3 SMAD2 SPARC TRPC1 SMAD4 MMP9 COL3A1 COL1A1 LOX MMP2 MMP3 VCAM1 TRPC6 TRPC3 PMC8327170__F3 Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma IGF1 IGF1R TRAF3 PMC6146524__F4 Galactose metabolism, glycosylation and inflammatory cascades in galactosaemia LEP FUT8 UGDH ALG9 MGAT3 LEPR ANXA1 PMC8574228__F1 Signalling pathways in cardiac hypertrophy RGS2 PLN TRPC1 CNP MTOR RHO IRS1 EIF4E SIRT3 PDE9A GCA RGS4 HEL-S-11 TRPC6 TRPC3 PMC9353479__F6 Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co‐Culture Chip EGFR MTOR MYC CCND1 PMC8038842__F2 Human mitochondrial fatty acid biosynthesis (mtFAS) pathway MCAT PDHX MECR OXSM DLAT LIPT2 HTD2 LIPT1 ACSF3 LIAS DBT PMC4629004__F3 Changes in genes encoding components of the glycolytic, TCA cycle, and mitochondrial NADH shuttle pathways in gastrocnemius muscle in response to BCATm KO SLC2A4 CS SLC16A3 SUCLG1 SUCLA2 MDH2 PFKM GOT2 ACO2 HEL-S-133P HK2 LDHB HEL-S-30 GPD1 SDHD SDHA SDHB PGAM2 GPD2 SLC25A12 ENO3 SLC25A11 FBP2 HEL-S-68p OGDH HEL-S-162eP SUCLG2 DLD ENO1 HEL-S-87p SDHC PMC4408550__F1 Activation of TGFB requires liberation of the TGFB dimer from an inactive latent complex with the LAP PLG ARHA FURIN PMC4629004__F2 BCATm KO on protein synthesis pathways RPL8 RPS15 RPS15A RPS14 RPL38 RPS8 EIF3F RPS17 PAIP2 AAG1 RPL27A RPS21 EIF3S2 EIF3K RPSA RPS19 RPS18 RPL23 IRS1 RPS7 EIF4E RPL19 RPL35A RPS26 RPS29 RPS20 EIF4G1 EIF3G RPS24 EIF3E PPM1L FAU RPL36A EIF3D RPS4Y1 EIF3M EIF3B ELF3 RPL18 RPS6KA2 DDIT4 HEL-S-310 RPS16 RPS10 EIF3S3 RPS3 RPL27 EIF2A ELF5 RPL22 RPS6 EIF4B RPS5 RPL11 RPS2 EIF2AK1 ELF2 RPS27A RPL21 EIF5 PPP2R1A RPL15 RPL13A EIF3C SUI1 PPP2R3A RPS25 RPS12 RPS9 PPP2R5A PMC8613644__F2 Cell-free network communication in alcohol-associated disorders and liver metastasis ZFP36 HPSE HEL-S-101 RAB27A TGFA SDCBP HGS RAB27B PLEC ADARB1 AKT1S1 RAB9A EXPH5 HTT PMC4278286__F4 Altered metabolic pathways in clear cell renal cell carcinoma: A meta-analysis and validation study focused on the deregulated genes and their associated networks SLC12A1 EHD2 STAT3 SPAG4 NPHS2 HEL113 LHX1 TIMP1 SLC34A1 ENO2 PLSCR1 HIF1A IGFBP2 ABCA1 LIPA STAT1 BTG1 FLT1 SP1 PSMB8 CD14 VEGFA GATA3 ALDOB SCARB1 HEL-S-87p CA9 BHLHE41 NR3B3 PMC3895605__F2 Possible signalling pathways involved in enteric neurogenesis by a 5-hydroxytryptamine 4 receptor (5-HT4R) agonist mosapride citrate (MOS) CDC42 SPRY2 TRIR EDN3 KIF26A GDNF MOS EDNRB PTEN RHO GRB2 RET PMC8699756__F3 Transcriptome Analysis in Vulvar Squamous Cell Cancer ANAPC10 ANAPC13 CDC20 WEE2 ANAPC7 ANAPC11 CDC23 ANAPC2 MYC EFS SPN FZR1 E2F4 CDC45 MCM3 ATM HEL-S-1 CDC37 CDC27 MCM2 TFDP2 HEL2 PMC3703268__F6 Network view of TGF-beta signaling pathway alterations in colorectal and ovarian cancer SKIL MYBL2 MAPRE1 SMAD2 ZFYVE9 ZNF7 SMAD4 CPNE1 NCOA6 MYC MAPK3 TGFBR1 TGFBR2 FOXH1 MAP2K4 NCOR1 CLU HSF1 TRIB1 APC TGIF2 NR2A1 PPP2R2A MAP3K7 CREBBP EP300 MAP2K1 PMC6685260__F5 Molecular characterization of subpathway signatures GNB1 GNAI3 GABARAP RAF1 PGR c-fgr GSK3B CHUK GABARAPL2 GNGT2 PMC10743556__F2 Keap1/Nrf2/ARE signaling pathway KEAP1 NQO1 PMC3188957__F4 Highest confidence network of genes influenced by CLOCK knockdown ANTXR1 UGT2B15 CD36 MGAT3 UGT2B10 MIF UGT2B17 S100P PMC3534992__F7 MiR-146b function in IEC-6 cells mediating TGFB signaling SIAH2 SMAD2 SMAD4 PMC8039382__F2 Metabolic and signaling networks involved in anoikis-resistance mechanism STAT3 EGFR FASN PTEN MTOR MYC PMC8103695__F5 Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo RHEB TSC2 TSC1 GSK3B DEPTOR IRS1 PMC4170681__F1 The genetic signatures of pediatric high-grade glioma: no longer a one-act play CCND3 CDK6 CCND2 CCND1 CDK4 PMC4882600__F8 RhBMP-2 Activates Hippo Signaling through RASSF1 in Esophageal Cancer Cells LATS1 LATS2 CDK6 RASSF1 GSK3B BMP2 CCND1 CDK4 PMC8088956__F2 Dysregulation of Wnt/B‐catenin signaling by protein kinases in hepatocellular carcinoma and its therapeutic application EGF HGF EGFR APC NEK2 GSK3B AXIN1 LRP5 PAK4 LRP6 NLK CTNNB1 PMC6165531__F1 The sugar metabolism (green) and signaling (blue) pathways TES OGT FIS1 RGS1 PMC3089884__F5 Chemokine Signaling Pathway CLU RAG1 SHE PMC7603127__F2 NRF2 directs numerous metabolic processes that impact cancer cell survival and proliferation, including NADPH production and the metabolism of lipids, amino acids, nucleotides, and iron/heme (a) MTHFD2 HEL107 FAS GLS GPX4 GCLM ME1 FECH HEL-S-51e HMOX1 TXN PHGDH GCLC SHMT1 PSAT1 ASNS HEL-S-26 HEL-75 PMC9406467__F3 Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer? VRK1 CHEK2 ATM PMC4935811__F3 Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards CX3CR1 ARG1 IRF8 PMC4736825__F4 Model of translational repression of Nodal pathway components XCR1 YBX1 NODAL ELF3 PMC6393772__F6 Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways CDH2 BRAF ZEB2 SRC PMC6393772__F7 Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways GSK3B BRAF SRC CTNNB1 PMC7432012__F3 Tumor necrosis factor beta (TNFA), interleukin 1 beta (IL-1B), bone morphogenetic protein (BMP), and transforming growth factor beta (TGFB) are stiffness-dependent signaling pathways SMAD1 ALPL MAP3K7IP1 DKFZp781O1323 SMAD2 SMAD4 COL10A1 ATF2 RUNX2 IL1B PMC3931462__F8 Proteolytic cleavage of CDCP1 contributes to enhanced tumor cell survival and motility through the FAK and Akt signaling pathways downstream of complex formation between cleaved CDCP1 and B1 integrin PLG SRC CDCP1 PMC7432012__F4 Material stiffness-induced Wnt signaling APC LRP5 LRP6 CTNNB1 PMC9534854__F9 BNC1-Merlin-Hippo-YAP signaling -Ferroptosis axis LATS1 BNC1 LATS2 GPX4 FACL4 NF2 PMC6393772__F2 Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways PDPK1 LIMK1 RHO PMC8750485__F1 Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases NNMT SARM1 KYNU KMO NAMPT PMC11847137__F9 Schemic working model revealing the possible role of ZC3H15 in mediating BCP ZC3H15 KEAP1 NQO1 GCLC PMC5604081__F1 Regulation of intrinsic cancer metabolism by obesity-associated growth factors ACLY FAS IGF1 HEL-S-133P HK2 IGF1R CS MTOR MYC HEL-75 PMC9434279__F1 Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus IAPP IL1B PMC3732476__F2 Notch signaling pathway MAML1 ADAM17 ADAM10 PMC7555059__F1 Hierarchy of repair pathways choice in mammalian cell RAD52 RAD51 BRCA1 PAXX BRCA2 POLE PMC6240761__F1 Hypothalamic-pituitary-adrenal axis signaling IGF1 EGFR CRH GC CCR2 CCL2 TNF GHR PMC7555059__F4 Proposed antagonistic relationship of 53BP1 and BRCA1 during DSB repair pathway choice based on DNA resection BRCA1 H2AX ATM RIF1 PMC3121899__F3 Cartoons of PAR-1-dependent signaling by APC and thrombin in endothelial cells when EPCR is either free or occupied by protein C PC ARHA RAC1 PMC2806113__F6 Working model of TGFB actions in renal interstitial fibrogenesis TSC1 MTOR PMC6719047__F2 RTT-related protein known functional interaction networks GABBR2 MEF2C TRRAP ZBTB18 NCOR2 CHD4 ZFX RHOBTB2 CACNA1I KCNQ2 SCN2A ZNF620 HOMER2 PMC6518824__F3 Schematic indicating the pathway from Micronucleus formation to activation of the cGAS-STING pathway, and canonical and non-canonical routes to Type I interferon response CGAS RELB IRF3 PMC9629402__F7 In Silico and In Vitro studies of taiwan chingguan yihau (NRICM101) on TNFA/IL-1Beta-induced human lung cells TNFAIP6 JUN MAPKAPK2 CD14 IL6 TNF TRAF6 CXCL8 FOS COL1A1 MAP3K7IP1 MAP3K7 TRAF2 LBP PMC7690798__F2 Functional interaction network and molecular classes of the 20 genes with high RNAi efficacy from SF3B2 RPS15A LONP1 RAN PSMB3 EGFR LARP1 TERT RPL37 CTNNB1 SNRNP200 RPL5 RBX1 HSPD1 SNRPD1 EIF3E TBC1D3B SARS1 POLR2L EEF2 ERBB2 EIF3B RPL14 RPL7 PMC6438456__F10 Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers MLST8 RICTOR EGFR APC GSK3B PTEN HEL-S-11 MTOR CTNNB1 PMC6535785__F7 Probable molecular mechanistic pathway of ruthenium baicalein complex BAX PCNA CASP3 MTOR PMC5312370__F6 RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy STAT3 RAD51 MTOR PARP1 PMC8436408__F1 Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NFKB Modulators COX2 TLR8 TLR7 PMC4447524__F1 Resistance to BCR-ABL1 tyrosine kinase inhibitors may take the form of (left) point or compound mutation-based, BCR-ABL1-dependent resistance or (middle) recruitment of alternative pathway signaling upon effective inhibition of BCR-ABL1 POR STAT3 SRC FGF2 CP PMC2956608__F1 Inhibition of the type I interferon (IFN) pathway of Kaposi's sarcoma-associated herpesvirus (KSHV) IRF6 TBK1 CD14 IRF7 PMC8453146__F2 Kill and Clearance in HCC: An Approach Based on NK Cells and Macrophages CD40 CCL3 CX3CR1 CX3CL1 ARG1 CCL4 CCL5 CCL2 PMC6616015__F2 Gene-gene interaction networks CBX1 NRARP SMN1 PRIM2 RADIL ANGPT4 CARD14 MALL HEL-S-75 EPHX4 ARHGAP18 CDK2 OGDHL KCTD9 ADGRG6 REL RIMBP2 ZBED4 PMC2921274__F2 Eph receptors and ephrins in cancer: bidirectional signaling and beyond HRAS EPHB2 EPHA2 SRC PMC7390515__F2 TGFB signaling in health and disease SMAD2 SMAD4 PMC8699427__F2 Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease PER2 PER1 IL18 PMC2082051__F5 Networks of pathways unique in the HIV-1 regulated mPBMCs KLRC2 ZAP70 HLA-DMB CD244 HLA-DRB1 BRAF RPS6KA1 CTLA4 PTPN6 MAPK3 HLA-DMA HLA-DRA TYROBP PMC4920181__F5 An illustration showing roles or functions of analyzed retinal disease-related genes GUCY2D RD3 CRB1 CRX PCDH15 USH2A NR2E3 MAK RPE65 RP1L1 KCNV2 NPHP1 CC2D2A RP1 RPGRIP1 SAG FZD4 TLR3 TUB OTX2 RDH12 NDP PMC10859375__F5 Lipid laden macrophage accumulation in the p NPC2 LPL PLIN4 ACSL1 CD36 DGAT2 SCD PLIN1 FABP4 PMC7542331__F5 Regulatory loops around TGFB1 link important transcription factors and cytokines NR1i1 KLF2 EGR1 TGFB1 EZH2 TWIST2 CCL5 RUNX3 SNAI1 FOXO1 EDN1 KLF9 TWIST1 PMC6465591__F1 Lymphatic vessel functions during tumor progression CXCL12 VEGFC CCL21 CCR7 VCAM1 CXCR4 PMC1087229__F8 Signaling pathway of NGF-induced neurite outgrowth in PC12 cells CDC42 NGF VAV3 SOS1 VAV2 RAC1 PMC5293580__F5 Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways RHEB MAP4K3 MTOR PMC11622859__F4 Reconstitution of the biosynthetic pathway of CNs in this work and the semi-synthesis of ISIR-050 IPP PMC5386521__F1 Scheme depicting a molecular pathway by which Cdc25A is induced/activated and promotes neuron death in disease and development MYB CDK4 PMC3606047__F1 Adenosine Signaling During Acute and Chronic Disease States ADORA2A AHR ADORA2B PMC2921274__F4 Eph receptors and ephrins in cancer: bidirectional signaling and beyond FYN PTEN ARHA LCK PMC7214542__F1 Regulatory and catabolic pathways for glucose and xylose metabolism in E CRP HPR PTS GALP PMC3241422__F10 Control of Rho1 activity through the cell cycle ROM1 HMFT1766 PMC3724215__F1 IGF pathway EIF4B BAD SHC1 EIF4EBP1 PTEN IGF1R MTOR IGF2 EIF4E IGF2R IGF1 INSR GRB2 PMC7972191__F7 Graphic abstract showing how the KPNA2/CBX8/PRDM1/c-FOS pathway works in BCa KPNA2 BCOR PRDM1 CBX8 PMC5870182__F6 Schematic diagram illustrating the mechanism of WYHZTL formula in regulating Wnt/Beta-catenin signaling pathway APC GSK3B CCND1 CTNNB1 PMC12163303__F2 Mechanisms of translation regulation RHEB EEF2K TSC2 TSC1 EEF2 GRB2 PMC3426818__F5 MUC5B gene expression is transcriptionally regulated by various mediators and pathways ERBB3 SP1 MUC5B ERBB2 IL17A IL1B PMC9623415__F1 PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer MTOR PMC4240652__F6 Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet CXCR3 CRK TIAM1 JAK3 ARHA SHE PMC4240652__F8 Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet CD48 VAV3 LAT APC IL4 PPP3CA CTLA4 TNF DAO CBL FYN BCL10 IL2 ITK GRB2 CD3E LCK CDK4 PMC11002873__F3 Working model for the Wnt, TGFB, and Pax6 signalling in the regulation of ciliary body development SMAD1 DKFZp781O1323 MSX1 SMAD2 BMP4 SMAD4 PAX6 LEF1 AXIN2 MSX2 PMC4163376__F2 Simplified overview of the Rb/E2F pathway MCM7 MCM3 MCM5 MCM6 MCM2 PMC3148569__F6 Perturbed TGFB/Smad and mitogen-activated protein kinase signalling pathways in Dupuytren's fibroblasts BMP6 COL1A2 SMAD2 SMAD4 NODAL PMC7520270__F5 Enrichment and functional annotation by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) EPHA2 ENO2 COX2 HEL-S-66 STX3A GINS1 SLC11A2 UBC DAG1 ANXA2 ANXA1 PLEKHH2 KDELR1 STK39 CHD3 HMGCS1 AGR2 FTH1 SLC39A11 RAD51C SYTL2 SLC35A3 ALDH5A1 FTL ARL2BP ALDH7A1 PFKP CRABP2 CRABP1 PMC8458764__F1 Metabolic Contributions of Wnt Signaling: More Than Controlling Flight CDC42 TCF7L2 APC LRP5 LRP6 RYK ARHA RAC1 CTNNB1 PMC5858703__F4A Retinoic acid-related Orphan Receptor G (RORG): connecting sterol metabolism to regulation of the immune system and autoimmune disease STAT3 CD5L IL23R PMC7764399__F2 Various gut microbial stimuli due to dysbiosis can cause the initiation of inflammation in the intestine TH BAX TGFBI NLRP3 IRGM IL23R CARD9 PMC8458764__F2 Metabolic Contributions of Wnt Signaling: More Than Controlling Flight APC GSK3B CTNNB1 PMC7284378__F5 Proposed mechanisms for protective effects of MWF on chronic alcohol-induced liver injury LPA HMGCR ACAT2 PMC8882905__F4 Antiplatelet Therapy in Patients With MINOCA VWF COX1 IL1A PMC5963346__F3 DEGs associated with TNF signaling pathway at different time points after cerebral ischemia MLKL CASP3 TNF PMC9623415__F2 PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer GSK3B MTOR CREB1 CDK4 CTNNB1 PMC6462347__F5 Schematic overview of the folate metabolic pathway mediated by FOLR, DHFR, and MTRR FH DHFR MTRR MTR PMC4803789__F2 Molecular regulation of autophagy ATG101 ATG10 ATG3 ATG16L1 ATG12 ULK1 WIPI2 UVRAG BCL2 ATG5 PMC12006828__F15 Biosynthetic gene cluster and (B) proposed biosynthetic pathway of stipitatic acid TSR3 TSR2 TSR1 PMC7002875__F8 KDM5C is a SAHA-sensitive marker of a druggable pathway damaged in NDDs SCN2A KDM5C ZNF711 BDNF SYN1 ARX PMC12006828__F11 Biosynthetic gene clusters and (B) the proposed biosynthetic pathways of helvamide B and arizonamides ATR PARG PMC6441734__F6 JNK pathways in mammals and drosophila LRRK2 ATF2 ME1 PMC3575449__F1 From photomorphogenesis to cancer RFWD2 CSN3 MDM2 SKP2 CSN2 PMC6477797__F6 Biological pathways associated with non-synonymously mutated genes in TCL1 mice CD40 ARHH ITGA7 EGFR PIK3R1 PTEN MTOR TRAF3 KRAS ELF4 MED12 NR1C1 BCR PI3 F3 IKBKB NPM1 NUTM1 PMC6322364__F7 TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress CDC2 FANCD2 ATR PCNA BRCA1 TIA1 PMC8436938__F13 Siberian fir terpenes extract Abisil on antioxidant activity, autophagy, transcriptome and proteome of human fibroblasts CDC2 STAG2 DBF4 CDC20 PCNA CDC6 STAG1 ORC6 SMC3 GSK3B SMAD4 ORC3 SKP2 MED1 ORC2 CDK6 CDK7 E2F4 CDC45 CDK2 MDM2 CDK4 PMC4256277__F4 Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway TXNDC16 ARHGAP22 SEC61A1 MUSTN1 SLC39A14 CMKLR1 STARD8 ASPSCR1 NR1D1 THAP7 ERGIC1 TRIM2 HSD3B7 MGAT1 USP36 DNA2 DOLPP1 FDPS SRC GOT2 TLE3 RAB34 LRP5 LRP6 LGALS9 BAIAP2 EHD1 PMC4256277__F2 Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway ARHGAP22 STARD8 PARVG ASPSCR1 TMEM109 COQ3 ERGIC1 MTIF2 TATDN3 TRIM2 SCRN1 HSD3B7 RAB40C RHO MTOR QSCN6 CHCHD7 PAPOLB CYTIP STARD7 ADHFE1 MYO7A NIPA2 FHDC1 DOLPP1 VPS18 SRC CPT2 PXMP2 CAD RAB34 RPL35A TFAM BAIAP2 EHD1 PMC3596326__F4 Structural Phylogenomics Reveals Gradual Evolutionary Replacement of Abiotic Chemistries by Protein Enzymes in Purine Metabolism AMN PMC3805607__F3 Comparative Transcriptional Profiling of 3 Murine Models of SLE Nephritis Reveals Both Unique and Shared Regulatory Networks TH ALPL RRAD CCK PILRA SELPLG IL3 SPARC MARCKS PRKCZ STAP2 AMN PROZ APEH HEPH PROS1 MSRB2 MMP2 POLE AMACR GCDH VEGFA CELF2 HEL-S-8a ITGAM MGP RELA HFE PLTP LYN HAGH PMC4760780__F7 Proposed model for Usp12 function in the pathway of TCR signaling USP12 LAT USP46 TRAT1 PMC5732848__F1 Environment Matters: Microglia Function and Dysfunction in a Changing World TREM2 NGF IGF1 HEL-S-62p BDNF PMC8465283__F1 p53 mRNA Metabolism Links with the DNA Damage Response HUS1 BAX TOPBP1 ATR ATRIP PML PLK4 MDC1 XPC BRCA1 POLK RAD17 ATM GADD45A PMC3805607__F2 Comparative Transcriptional Profiling of 3 Murine Models of SLE Nephritis Reveals Both Unique and Shared Regulatory Networks STAT3 PYCARD TGFB1 RELB HEL-S-51e CCL2 FLNA CTSC DOCK2 ASPA PLEK ABAT LITAF PRKCE TYROBP F2R OSMR PARP2 MCCC1 PLD4 MTHFD2 DOCK10 ACADS HEL-S-130P RHOB DKFZp686P11128 RRAS ASNS HLA-C PMC9709205__F3 Impact of SOX2 function and regulation on therapy resistance in bladder cancer COX2 SOX2 IGFBP1 IGF2 PMC10417115__F2 miRNA binding sites at the rs8720 and rs12587 variants of the KRAS gene and their function in tumor regulation SP1 PTEN KRAS PMC3947785__F1 What’s the Mtrr with your grandparents? F2 F3 MTRR MTR PMC9532536__AF1 Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway CDC2 FOXM1 KIF20A A2M CCNB1 PLK1 PMC3567816__F1 A summary of the newly proposed inflammasome activation pathway including PKRs' recently found role NLRC4 NLRP1 HMGB1 NLRP3 AIM2 IL1B PMC8003318__F2 miR-29a and HCC carcinogenesis SMARCE1 MCL1 PTEN MDM2 APAF1 PMC8003318__F3 miR-29a as an epigenetic modifier SOCS1 TET2 AFP TET1 TET3 SETDB1 MMP9 PMC8003318__F4 Role and mechanism of miR-29a in metabolic adaptation SPARC ROBO1 SIRT1 PMC8003318__F5 ceRNA acts as miR-29a sponge to positively promote HCC progression MCL1 ROBO1 TUG1 C22orf13 PMC8003318__F6 miR-29a as a regulator of tumor microenvironment STAT3 LOXL2 IFITM3 IGF1R VEGFA ROBO1 CLDN1 PMC8405630__F4 Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy CDC2 ATR CDK6 RRN3 CDK2 ATM MDM2 TBP CDC25B CDK4 PMC5030232__F7 Major metabolic pathways anticipated to participate in spore germination process in N HEL-S-304 RPIA ADK PMC6473282__F6 Proposed regulatory mechanism of estrogen in colitis-associated colorectal cancer at week 2 (A) and at weeks 10 and 16 (B) NLRP3 COX2 GCLM GCLC TNF PMC5435615__F5 Diagram of heme effect ECSIT CD80 TIRAP TXNIP TAB3 TRAM1 IRAK1 IL6 TRAF3 TNF TRAF6 IRAK4 MYD88 HEL-S-92n MAP3K7IP1 MAP2K4 NLRP3 TLR4 MAP2K3 TRAF2 TRAM2 PMC4116803__F1 Improving GD T cell functions by TLRs in combinatorial therapy IPP CD69 MICA PMC8301900__F3 Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway BAD CDK6 PTEN MTOR FOS CDK4 PMC6834161__F2 Working model of FH physiopathology and the effects of CoQ PCSK9 LDLR ABCA1 PMC7882549__F2 Mevalonate pathway and possible mechanism of action of statins BAX EGFR BCL2 RHO PMC6617458__F3 Microbial N-cycle and chitin convergence and degradation pathway mediated through the addition of chitin NAPA KIN PMC8944541__F5 Venetoclax-Resistant MV4-11 Leukemic Cells Activate PI3K/AKT Pathway for Metabolic Reprogramming and Redox Adaptation for Survival EN2 EN1 PMC6607732__F1 STING pathway activation in DNA repair deficient breast cancer TBK1 CD80 CGAS IRF3 CCL5 CTLA4 FOXP3 CXCL10 LAG3 PMC5431893__F1 Pathway of “aryl hydrocarbon receptor signaling”-initiated smoking-related cancer SMAD6 AHR DUSP4 PAH AHRR SMARCA4 PMC7506147__F1 In the cytoplasm, PTEN mediates dephosphorylation of PIP3 to PIP 2 which inhibits the PI3k/Akt/mTOR signaling pathway leading to slower tumor growth BMI1 PTEN MTOR KRAS PMC4442271__F1 Obesity, immunomodulation and chronic kidney disease LTB LTA COX1 COX2 C2 IL6 PMC7998562__F1 Complement activation pathways C6 CD59 EED FH C7 HEL-S-62p CD46 CD55 INS C4A C2 C9 C4B_2 PMC10311182__F1 Key piece of the airway remodeling puzzle revealed—LIGHT signaling in the lung LTBR RELB TRAF3 TRAF2 PMC8864109__F6 lncRNA Mirt1: A Critical Regulatory Factor in Chronic Intermittent Hypoxia Exaggerated Post-MI Cardiac Remodeling TUBB4A VTI1A ALPI ALPL CNGA4 LAMA1 AGO2 BMP3 GREM2 RHO ANGPT2 OTP SAP30 INHBA PAX5 ATXN1 ZEB2 RDX PMC8289790__F1 Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment STAT3 IL10 NR1C1 SMAD2 SMAD4 HIF1A FOXP3 MTOR PMC8289790__F2 Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment SMAD4 PTEN FOXP3 MTOR CPT1A PMC6429583__F2 Homology of the GSH synthesis pathways in mammals and Caenorhabditis elegans GCLM GCLC GC PMC3670113__F1 Role of SHIP1 in bone biology ID2 INPP4B PI3 USP1 GSK3B PTEN CTNNB1 PMC2842081__F1 Telomeres: protecting chromosomes against genome instability ATR DKC1 WRN ATM TERT BLM POT1 TPP1 PMC5842023__F8 T cell receptor signaling pathways in eosinophilic asthma ZAP70 CD48 CD2 CBL FYN BCL10 LAT ITK GRB2 DAO LCK CDK4 PMC6888549__F1 Wnt signaling pathways SOST APC LRP5 LRP6 CTNNB1 PMC6547487__F5 Functional significance of several key genes from four KEGG pathways differentially expressed in female and male magpies EEF2K JUN NR2A1 RUNX1 LAT APC ATM JAK1 RORA PMC6189633__F3 Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity TRAK1 ATPAF1 LRRK2 BACE1 COX5A MAPK9 CS PSEN1 PRDX3 GPD2 APH1B CASP3 CPT1A HEL-75 PMC5522964__F1 Epithelial to mesenchymal transition (EMT)-inducing transcription factors and the reported E3 ubiquitin ligases that govern their stability FBXW8 FBXL14 MDM2 PMC5832878__F7 DAX1 promotes cervical cancer cell growth and tumorigenicity through activation of Wnt/Beta-catenin pathway via GSK3B APC GSK3B CCND1 CTNNB1 PMC6890794__F7 Summary of changes to the Wnt pathway as a result of AD + TS treatment CD44 STAT3 CASP3 CTNNB1 PMC2657106__F1 Activation of the G2/M checkpoint after DNA damage CDC2 ATR APC WEE1 ATM MYT1 PLK1 PMC8859819__F4 Epigenetic regulation of inflammation by microRNAs in post‐infectious bronchiolitis obliterans FLT3 DKFZp781O1323 SOS1 BMPR1A PIK3CD CCR2 SKP2 CCL2 CXCL8 CXCL3 INHBA INHBE EPOR OSMR CCR7 KDR DCN BMPR2 ACVR2B IFNA21 VEGFA IRS1 FOXG1 TNFRSF10D IL25 CCL24 CCL19 ATG12 CCL25 IFNAR1 IL8RB BMP5 SMURF2 SIRT1 CCL20 TNLG5A CD27 CCL26 IGF1R TGFBR1 TGFBR2 PPBP NOG ROCK1 ACKR3 IF2B1 CXCL16 KIT CXCL2 IL17A BCL2L11 KRAS ZFYVE16 GDF5 FOXO3A ACVR1 RPS6KB1 BMP2 CCR4 SKP1 CREBBP IL6ST BCL6 PMC9194136__F5 Exploring the metabolic landscape of pancreatic ductal adenocarcinoma cells using genome-scale metabolic modeling ACLY GOT2 HEL-S-133P FASN MAL ME1 KRAS PMC6120815__F1 Innate Immune Signaling and Alcohol Use Disorders IFNG HMGB1 TLR4 CCR2 IRF7 TLR7 TRAF6 PMC7407180__F5 Proposed biosynthetic pathway leading to terpenoids in A IPP MVK PMC4398671__F8 Schema of structure and signaling pathway of G-CSFRI and G-CSFRIV TP53INP1 SOCS3 CCL2 PMC2667983__F4 Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia LIF TIGAR SCO2 MDM2 PMC8224255__F2 Efficacy of phytochemicals as immunomodulators in managing COVID-19: a comprehensive view IL2 IL6 ACE2 PMC8883632__F10 Abundant expression of ferroptosis-related SAT1 is related to unfavorable outcome and immune cell infiltration in low-grade glioma IFNG FER CLEC2D ALOX15 PMC9382640__F2 Mechanisms and prospects of circular RNAs and their interacting signaling pathways in colorectal cancer GSK3B MTOR PMC7666199__F4 Reconstructed hydrogenotrophic methanogenesis metabolic pathway with associated carbon fixation through the reductive Acetyl-CoA pathway, methane metabolism and coenzyme biosynthesis by Methanobacterium sp POR MTR PMC5244562__F1 Scheme of PI3K pathway with candidate regulators of mTORC2 colored in green MLST8 RICTOR MTOR IRS1 PMC4433776__F1 HHLA2 interaction with two receptors to regulate T cell functions TMIGD2 APC HHLA2 PMC5915062__F4 Proteomic alterations in early stage cervical cancer JUP CALU KRT10 PKP1 HEL-S-84 TUFM FHL2 ATP1B1 PTPRF DSG2 EVPL DSG3 ATP6V0D1 GBP1 IVL FLNA DSC2 CDK6 CRABP2 KRT13 PPL TOP2A CDK4 PMC5915062__F5 Proteomic alterations in early stage cervical cancer RFC2 FEN1 PCNA RRM2 HEL-S-269 TAP1 FMR1 PLAA SMARCA5 HEL-S-99n MYO1E TACC2 MCM7 MTHFD1 MRM3 PRKDC MCM3 MCM5 MCM6 RFC3 SMC2 MCM2 PMC5915062__F2 Proteomic alterations in early stage cervical cancer RFC1 HEL-S-107 FEN1 KDM5A LMNB2 XBP1 ORC2 S100P PLAA RB1 TPR MCMBP KAT7 PCM1 RABL6 PAX8 MCM3 WDHD1 FOXK2 MCM6 PCLAF PMC5915062__F3 Proteomic alterations in early stage cervical cancer RIC8A HEL-S-269 SMC3 NAMPT TAP1 SMC1A PLAA HEL-S-99n TPR HLA-DRA ERAP1 NUP153 NUP93 MCM3 WDHD1 HEL110 MCM5 MCM6 MCM2 DDX3X NUP98 PMC7891830__F2 Golgi resident proteins and membrane trafficking pathway FGD1 ZNF547 CGN ATP2C1 ARFGEF2 PMC9279440__F5 Investigation on the cellular mechanism of Prunetin evidenced through next generation sequencing and bioinformatic approaches against gastric cancer LOX PIG59 TLR3 H2AX CYLD FADD PMC5935095__F3 Cooperative Instruction of Signaling and Metabolic Pathways on the Epigenetic Landscape MTAP MTOR PMC4377623__F2 Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis LAP3 PMC9020266__F1 Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair PNKP RAD52 RAD51 BRCA1 PAXX BRCA2 ATM PALB2 BLM PMC6538740__F1 Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment STAT3 ATR RAF1 EGFR PML SFN MTOR MYC PIN1 VCP CTNNB1 STUB1 MAPK14 POR RB1 CHEK2 CHUK APP HEL-S-11 HEL-S-1 KDR SRC HNRNPK CCND1 TOP2A NR1i1 UBC ARRB2 EEF1G YBX1 PPP2R1A TUBB LRPPRC VHL PARP1 ELAVL1 PRKDC RELA HSPA4 NFKBIA CREBBP CDC37 SIRT1 PS1TP5BP1 PMC7407977__F9 Molecular signal pathway of the proposed cell death crosstalk in B16 cells exposed to plasma induced-ROS BAX ATG5 FADD PMC8378592__F2 Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways IFNG GRAP CCL3 IL16 IRF9 ACE2 CSF3 PMC9662279__F5 SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases TRPM2 MTF1 RELA NAMPT SKP2 TNF SIRT6 PMC8378592__F3 Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways CD40 SYK LTA LEP TIRAP LAT CD14 BLNK TRAF3 TRAF6 LTB NGF BTK TRIM25 BCR COX2 IL16 TLR4 ATM VCAM1 TRAF2 EDAR PMC3145778__F9 Redox-Induced Src Kinase and Caveolin-1 Signaling in TGFB1-Initiated SMAD2/3 Activation and PAI-1 Expression EGFR RHO PMC9662279__F7 SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases RHEB FOXD1 SP1 ATG12 MTOR REL GATA4 SIRT6 PMC7201075__F1 Arachidonate-prostanoids pathway gene expression in colorectal cancer (CRC) tumors PTGER2 PTGER3 PTGS2 PTGDR PTGIS HPGD PTGER1 PTGES3 PTGS1 PTGES PTGER4 PTGFR PTGIR PMC4325920__F1 Roles of FMRP in the pathogenesis of AD MAP1B GSK3B PTEN MTOR ARC MAP2 EIF4E RHEB TSC2 SYNGAP1 TSC1 FYN NF1 PAK1 APP PMC3536146__F8 Pathway representation of canonical and Pyk2-mediated TLR9 signaling TBK1 JUN TLR9 IRF3 IRAK2 TRAF3 SHE TRAF6 FADD MYD88 PMC10526250__F1 Changes in the Acetylcholinesterase Enzymatic Activity in Tumor Development and Progression BAX BAD PMC3322338__F1 Hypothetical model for neuroimmune-related actions of miRNAs in brain of human alcoholics (e.g., in microglia) TLR4 IRAK1 IRAK2 SOCS3 TRAF6 CXCR4 IRAK4 MYD88 PMC5187688__F5 TCA pathway ME2 CS PMC5379509__F8 Novel one-class SVM based negative data sampling method for reconstructing proteome-wide HTLV-human protein interaction networks GRAP2 WDR12 MESP2 VASP HEL-S-81p DTX2 ITCH LAT TLE2 PSENEN CDK6 BCL10 WAS UBB THEMIS SPEN UBC AGO1 LCP2 NCK1 NEUROD1 MIB1 RNF31 TBL1X NKAP CCNC HGS PTPN22 RBX1 RELA ZNF423 ETV2 SNW1 PMC5712622__F3 Akt/mTOR pathway represents a major axis of phosphorylation signal transduction in response to phagocytosis RPS6 RPTOR EIF4B BAD GNB5 PTEN MTOR MYC PCK1 IRS1 CTNNB1 EIF4E RHEB TSC2 BCL2L1 RICTOR TSC1 BCL2 AKT1S1 GRB2 CCND1 PMC3474235__F1 The prostaglandin biosynthetic pathway (adapted from ) 15-deoxyΔ12-14-PGJ2 is a metabolite derived from arachidonic acid GSTM1 PMC4900217__F2 Induction of oxidative stress and defense pathways NOS2 XDH URAD HEL-S-64p NOX4 HEL-75 PMC7782450__F3 Amino acid catabolism caused by ARG1 and IDO triggers a shortage of l-arginine and tryptophan, disturbing the homeostasis of host tissues ARG1 ATF4 MTOR EIF2A PMC3474235__F2 Scheme of the various interactions between GSTs and MAPK implicated in stress-signaling pathway (adapted from ) GSTA4 TRAF2 PMC4900217__F6 Metabolic reprogramming for NADPH production HPD HEL107 RPE HEL-S-304 RPIA F2 HEL-S-49 GCK RBKS PSPH PMC5564037__F4 Capturing Human Naïve Pluripotency in the Embryo and in the Dish KLF4 STAT3 TET2 DPPA3 TFCP2L1 KLF2 TET1 LIF APC GSK3B LRP5 SOX2 CTNNB1 TCF3 DNMT3L TBX3 UHRF1 JARID2 SP5 PMC8914318__F7 New Vistas in microRNA Regulatory Interactome in Neuropathic Pain DUSP5 IL10 TIRAP TXNIP SMAD2 SMAD4 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 MAP3K7IP1 NLRP3 TLR4 GRB2 CXCR4 TRAF2 PMC7961479__F1 Predominant signaling pathways contributing to melanomagenesis and progression RHEB TSC2 MTOR PMC6801787__F1 Schematic illustration vitamin D synthesis pathway and signalling mechanisms relevant to PAD formation VIT CYP27B1 DBP CYP27A1 PMC7961479__F2 Activating mutations and activation of alternative upstream receptors confer resistance to inhibitors targeting aberrant MAPK signaling RHEB TSC2 BRAF MTOR RAC1 PMC8619854__F3 Promising Role of TGFB Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report FAS FYN TGFBR1 PMC9397497__F6 Electrical stimulated GLUT4 signalling attenuates critical illness‐associated muscle wasting FOXO3A MTOR TBC1D4 PMC3370605__F1 Roles of N-acetyl-l-glutamate synthase (NAGS) and of its homologous enzyme N-acetyl-l-glutamate kinase (NAGK) in arginine biosynthesis NAGS OTC NAGK ARG1 PMC6691238__F1 Cell apoptosis under ER stress BCL2 ATF4 EIF2A TRAF2 PMC3078503__F4 PIKKs and TCR-associated pathways BAX ATR ATRIP BRCA1 H2AX ATM MDM2 PMC4662426__F5 Difference in expression of the calcium signaling pathway between rat neurons and OPCs grown in vitro PLN CAV3 CAV2 BCR MCU LCK PMC12075545__F6 IFN-Gamma-mediated suppression of ANGPT2-Tie2 in endothelial cells facilitates tumor vascular normalization during immunotherapy STAT1 FOXO1 JAK1 ANGPT2 PMC4438385__F1 Brown adipose tissue uncoupling and thermogenesis TG UCP1 PMC4332855__F3 Mycobiota: interactions between commensal fungi and the host immune system STAT3 STAT1 DOCK8 CLEC7A S100A9 IL1B CARD9 IL12RB1 PMC9774157__F6 Maqui Berry and Ginseng Extracts Reduce Cigarette Smoke-Induced Cell Injury in a 3D Bone Co-Culture Model KEAP1 NFATC1 MMP9 PMC4919473__F7 Inhibition of LINE-1 retrotransposition by the SLX4com prevents pro-inflammatory signaling SLX4 EME1 PMC6204284__F2 An illustration of spontaneous DNA double strand break induction and their roles in maintaining the stemness and tumorigenicity of cancer cells STAT3 CAD CASP3 ATM PMC11881714__F2 Normal copper metabolism ATOX1 CCS ATP7B COX17 COX11 HEL-S-44 ATP7A CP PMC11881714__F3 Mechanisms of neuronal damage attributable to Cu toxicity APP TNF HEL-S-44 PMC12095056__F4 Cilia and ciliary signaling contribute to therapeutic resistance ATR SOX2 BCL2 ATM ABCG2 ABCB1 PMC4868425__F8 The GLUD2 genotype effect on mouse metabolome HEL-S-304 CREBBP PMC6148547__F6 MiR-106p-5p in cervical cancer: from expression to molecular mechanism COMP ITGB1 GNG4 GSK3B MTOR VEGFA PMC7376809__F1 An update on stem cell therapy for Asherman syndrome SMAD2 APC SOX2 GSK3B SMAD4 CTNNB1 PMC5104320__F4 MinePath: Mining for Phenotype Differential Sub-paths in Molecular Pathways ERBB3 NRG2 NRG1 HBEGF PIK3R5 EIF4EBP1 EGFR CDKN1B AKT3 BTC GRB2 MTOR PMC4579870__F2 Core UPR pathway and its modulation on autophagy RHEB TSC2 FOXO1 ULK1 ATF4 EIF2A ATG5 ULK2 TRAF2 PMC4579870__F1 Molecular events in autophagy pathway ATG10 ATG3 ATG12 UVRAG ATG5 PMC5807095__F9 Signaling events that are induced by the LH surge and regulate the processes of ovulation and luteinization PRLR STAR EBP CYP11A1 NRP1 APLN PLXND1 HEL-S-61p PTGFR RUNX2 EMCN PMC5807095__F3 Hedgehog signaling pathway components in the ovary ACTA2 STAR CYP17A1 HHIP PTCH2 PTCH1 DHH IHH SMO GDF9 GLI3 PMC4548949__F3 Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus PLB1 ACLY TH TNC THBS2 OTC ACACA DCTD GDA LCT DGAT2 NR3A2 TPM3 GCK FHIT DGKZ ARG2 LPL THBS1 JUN FASN LIPG NR1C1 DLAT POLE4 DTYMK PRODH PHOSPHO1 MYL4 PMC4548949__F4 Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus PTDSS2 CYP2A13 PDIA4 JUN THBS1 CYP17A1 DNAJB1 HK2 APOE PRKCZ IGF1R PISD LIPG IRS1 FGF8A ADRB2 MMP2 HEL-S-61p GCK HEL-S-87p CPT1A DCN PHOSPHO1 PS1TP5BP1 PMC4846903__F5 ErbB4 signal pathway EGF SHC1 ECD SOS1 ITCH ERBB4 PGR EGFR WWP1 ERBB3 NRG1 GFAP ADAM17 NEDD4 PI3 WWOX CSN2 S100B PMC3784453__F10 Leu452His Mutation in Lipoprotein Lipase Gene Transfer Associated with Hypertriglyceridemia in Mice in vivo UCP2 LPL PGC TG SIRT1 PMC11068999__F4 Hh signaling pathway RB1 APC CTNNB1 PMC9268899__F1 Astrocytes in Neurodegeneration: Inspiration From Genetics LRRK2 APOE PARK2 SNCA MMP9 MTOR PMC11068999__F2 Wnt/Beta-catenin pathway RB1 APC CTNNB1 PMC11670693__F1 Inhibition of the canonical Wnt/Beta-catenin signaling pathway by BI 905681 RNF43 LRP5 ZNRF3 LRP6 TCF4 CTNNB1 PMC7961479__F3 MAPK, PI3K, and angiogenic reactivation confers resistance to c-KIT and VEGFR TKIs RHEB TSC2 MTOR PMC9581055__F10 Identification of Biomarkers Controlling Cell Fate In Blood Cell Development BAX JUN SP1 TNLG7A SMAD6 NFATC1 CDKN2B ERG RUNX2 GATA3 CTNNB1 FLI1 tal-1 SOX9 CDKN1C GJA1 PMC7664111__F7 Graphical rendering of GRP78-dependent CRIPTO signaling driving stem-like tumor cell phenotypes SMAD2 CRIPTO NODAL SRC PMC12035885__F2 Crucial environmental factors associated with NK cell function in the TME of breast cancer IFNG HDAC1 STAT3 IL2RA LDHB PMC12035885__F3 Main metabolites in the TME of breast cancer that affect NK cell function IFNG FTH1 HLA-G MICA MICB PMC4557010__F7 Schematic models for JAK/STAT cell signaling pathway and the inhibitory actions for JAK/STAT target anticancer drugs TF EGF LIF MTOR SRC PMC6855049__F6 Antifracture pathways of potential targets for treating fracture from main active ingredients of Drynariae Rhizoma CDC42 JUND RAF1 RXRA GSK3B APP ATF2 GRB2 SRC MYC TRAF6 TNF PMC5069086__F6 Schematic model for HCV-induced CD4+ T cell senescence regulated by the ΔNp63–miR-181a–Sirt1 and ΔNp63–miR181a–DUSP6 signaling pathways FOXP3 SIRT1 PMC4939511__F2 Signal pathways of migration inhibitory factor (MIF) CD44 JUN CD74 MIF PMC10149936__F14 Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth PAK4 RHO SRC RAC1 PMC7015662__F1 AIM2 inflammasome activation GBP5 PIF1 GSDMD IRF9 AIM2 PMC7120363__F2 Autophagy is involved in the regulation of the normal function of the intestinal mucosa and the pathogenesis of enteritis CGA ATG16L1 IRGM ATG5 XBP1 PMC3192861__F10 A schematic model of GC-mediated acute activation of NHE3 via SGK3 SGK1 GC GCGR SGK2 PMC7301251__F3 Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology HEL113 MMP14 PGR EGFR BRAF PTEN TERT MTOR MYC MAOA KRT19 IL-21 ABAT MMP2 ELANE ABCG2 BCHE ACHE BAX JUN PARG APC VEGFA TNF KRAS FGF2 VHL HRAS RXRA ERBB2 BCL2 PMC9528770__F2 Brain–immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders TRADD MTOR TRAF2 FADD PMC12045570__F2 Ferroptosis related signaling pathway affected by EBV, HTLV-I and KSHV viruses SLC3A2 SLC40A1 GPX4 SLC7A11 DHODH POR SIRT3 FANCD2 ATF3 LIPT2 CDKN1A ELAVL1 DPP4 PMC4862632__F1 Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro CRP STAT3 EGF CASP8 TRADD TLR4 EGFR RELA CASP3 MMP9 TRAF2 MYD88 PMC8881509__F7 Extracellular circulating miRNAs as stress-related signature to search and rescue dogs RFWD2 ATR PERP ATM MYC PMC7271281__F4 The ncRNA pivot regulator on the dysfunction module MISP PMC2897923__F1 Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression GSK3A COX2 APC TCF4 CCND1 PMC6721308__F2 Distribution of the genes significantly modulated in the Alzheimer’s disease pathway ADAM17 RTN4 PSEN2 BACE1 APP APAF1 PMC2897923__F2 Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression ROCK2 HEL-S-62p CTHRC1 ARHA RAC1 PMC9380335__F6 Impact of fetal exposure to mycotoxins on longissimus muscle fiber hypertrophy and miRNA profile SYK TSC2 BAD BCR CD37 RBL2 CD19 ME1 MDM2 GRB2 RAC1 PMC2897923__F3 Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression CD44 STAT3 KISS1 ROR2 PMC3205325__F2 Canonical TGFB signaling; Smad-dependent pathway downstream of TGFB receptors SMAD2 SMAD4 PMC4047858__F7 Combined metabolomics–transcriptomics identification of pathways affected by MPP+ MTHFD2 ROS1 PHGDH DHFR CTH PSAT1 TYMS HEL-S-51e PSPH PMC3477860__F4 Schematic diagrams of the role of STAT1 in antimycobacterial, antiviral and antifungal immunity CD40 STAT3 IL17RC STAT2 IRF9 IRF1 IL21R IRF3 TRAF3 IRF8 STAT1 TLR3 JAK1 IL23R TYK2 CARD9 IL12RB1 PMC7252450__F4 Advances in circular RNAs and their role in glioma (Review) STAT3 NOVA2 IGF2BP3 EGFR CFH FZD7 TCF2 MMP9 CTNNB1 HOXB7 PI3 NT5E CDK2 SOX4 CDK4 PMC6519821__F7 Proposed molecular mechanism of the anti-esophageal cancer activity of Rk3 BAX CASP9 BAD CASP3 MTOR ATG5 CCND1 CDK4 PMC7461358__F10 MiR-199a-3p and miR-199a-5p might affect MAPK signaling pathway by regulating DUSP5 and MAP3K11 MAX ACVR2A PLAT PARVA UNG PMC5137819__F1 Phosphatidylinositol‐3 kinase (PI3K)–AKT PI3K‐AKT pathway is activated upstream by ligand binding to a growth factor receptor, in this case a receptor tyrosine kinase (RTK) BAD FOXO4 FOXO1 PTEN MDM2 PDK2 MTOR PMC8250149__F2 NLRC5: A Potential Target for Central Nervous System Disorders LTA TRIM25 ATF1 TRAF3 TRAF6 CYLD PMC6820523__F9 Our proposed model of nsDNA-induced APOL1 expression through engagement of the cGAS/IFI16-STING pathway in human immortalized AB8/13 podocytes TBK1 STAT1 CGAS APOL1 IFI16 IRF3 JAK1 TYK2 PMC4031758__F2 Wnt signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC9333241__F8 Mapping of gene expression change on Na/K-ATPase/Src signaling pathway CRK SOST SPR FYN MAK CYCS CYC1 SHC3 PMC9465375__F4 Roxadustat: Not just for anemia TXN BCL2 PMC6324838__F1 Overview schematic of the proposed relationship of inhalant organic dust exposures induction of bone loss TLR4 CXCL1 NOD2 MYD88 PMC6770051__F5 miRNA-responsive biological pathways and the presence or absence of interactions between its genes and the transfected miRNA UFD1L SVIP CDC42 RGS14 OS9 UBC CAD UBE2G2 LACRT VAV2 LAT CASP12 GIP RHO ID1 CRK RBX1 PKD1 SKP1 HEL-S-11 DOCK4 EIF2A PMC2663984__F5 Expanded canonical Wnt/GSK3 signaling pathway APC LRP5 LRP6 CTNNB1 PMC5263152__F1 Canonical and non-canonical NLRP3 inflammasome activation HMGB1 NLRP3 IFNAR2 TLR4 IRF3 TNF PMC12210545__F3 Complement system and the role of HCQ HEL-S-62p C2 PMC8250149__F3 NLRC5: A Potential Target for Central Nervous System Disorders VEGFA CCND1 CTNNB1 PMC3031501__F8 Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells TSC2 GSK3B CDK2 MTOR SKP2 PMC4820338__F1 Schematic model of RIP1-mediated regulation of the PI3K-Akt pathway RHEB TSC2 TSC1 PTEN MTOR IRS1 PMC5034700__F1 Proposed metabolic pathway of lapatinib CYP3A4 PMC9169033__F4 Metabolic adaptations in MS FAS GLS PMC7791185__F9 NLRP3 Inflammasome Activation and Pyroptosis in Lactate‐stimulated Human NP Cells GSDMD NLRP3 ACCN3 PMC8326261__F3 Genetic variant of cyclooxygenase-2 in gastric cancer: More inflammation and susceptibility CCL3 USF2 CXCL1 USF1 TLR9 ATF2 TNF MYD88 PMC5520506__F1 PI3K/Akt signalling and its activation in cancer IGF1 AKT3 PTEN PMC7849620__F4 Mechanisms of abnormal coagulation and hepatic ischemia/hypoxia reperfusion injury in COVID-19-associated liver injury VWF TLR4 CCR2 TLR7 CXCL10 CCL2 CXCL8 IL1B PMC3355838__F3 Wnt signaling pathways APC LRP5 LRP6 ARHA NLK UNK CTNNB1 PMC3355838__F1 Step model of thyroid carcinogenesis TSHR BRAF PTEN CTNNB1 PMC3355838__F2 Genetic events involved in thyroid tumor initiation and progression TSHR BRAF PTEN PMC12154509__F4 SIRS signaling: inflammatory pathways during shock and cytokine storm and the production of soluble cytokine receptor antagonists TRAF6 IRAK4 MYD88 PMC10969160__F1 Summary of potential therapeutic targets MMP7 EGF APC SMYD3 LRP5 SOX2 LRP6 MTOR CTNNB1 HOXA5 BMI1 CD44 SUFU SMO PMC11866803__F10 Hsa_circ_0125356 promotes gemcitabine resistance by modulating WNT canonical and non-canonical pathways via miR-582-5p/FGF9 axis in non-small cell lung cancer ROCK2 AGO2 FGF9 ARHA DAAM1 CTNNB1 PMC12192441__F1 Signaling pathways of activins and other TGFB related ligands in adipocytes TF BMPR2 GDF3 ACVR2B SMAD1 ACVR2A DKFZp781O1323 SMAD2 SMAD4 PMC6580686__F1 miRNAs regulating the conserved pathways of aging in skeletal muscle TERT SIRT1 PMC4454460__F5 A model showing different pathways to repair replication fork damage due to structure-forming sequences RAD52 RAD51 PMC4436567__F2 Effectors interfering with SA-dependent signaling and gene regulation MED19 PMC7398379__F5 Proposed model of the transgelin mechanisms involved in promoting colon cancer metastasis NCKIPSD WAS CALM1 WIPF1 RHO RAC1 PARP1 PMC6321180__F3 Wnt1/Beta-catenin signaling as a key player in glia–neuron cross-talk IL16 GSK3B WNT1 PMC6321180__F1 Canonical Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) pathway and non-canonical Wnt/Ca2+ and Wnt/planar cell polarity (PCP) pathways [,,,,,] CDC42 APC ROR2 GSK3B LRP5 RYK ARHA PMC6321180__F2 Wnt1/Beta-catenin signaling regulation of midbrain dopaminergic (mDAergic) neuron survival/death according to our published findings [,,,,,,,,] APC GSK3B LRP5 LRP6 GPR49 LEF1 PMC7530130__F28 Enzymatic Noncovalent Synthesis MLKL RIPK1 TNF PMC7904711__F1 Shh pathway SHH SMO GLI3 PMC10150162__F9 Progress in non-viral localized delivery of siRNA therapeutics for pulmonary diseases RALA CCR2 PTEN CCL2 KRAS PMC9121315__F9 Hepatic pannexin‐1 mediates ST2+ regulatory T cells promoting resolution of inflammation in lipopolysaccharide‐induced endotoxemia PANX1 NLRP3 TLR4 IL33 PMC5732537__F8 Virus-induced endoplasmic reticulum (ER) stress and the consequent downregulation of the stimulator of interferon genes (STING) pathway in acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) TBK1 CGAS RNF5 IRF3 PMC9037064__F3 Progress in the Study of Non-Coding RNAs in Multidifferentiation Potential of Dental-Derived Mesenchymal Stem Cells BAMBI MAPK14 STAT3 STAT1 SMAD2 BMP2 SMAD4 FAT1 TCF4 JAK1 NOTCH2 CTNNB1 PMC4233036__F2 Pathway analysis highlights opposing regulation of a DNA repair pathway in radioresistant versus radiosensitive cells IFNG ATR ATM MDC1 PMC6610339__F1 Release of mitochondrial proteins and mtDNA initiates an inflammatory response in CICD BAX CGAS NLRP3 TLR9 IRF3 PMC9039039__F7 Research Progress of Exosomes in Bone Diseases: Mechanism, Diagnosis and Therapy CBL TOB1 PZP PMC2830572__F1 TNF A inhibits erythropoiesis by direct and indirect effects GATA2 EPOR EPO HIF1A PMC2811741__F7 Mast Cells Mobilize Myeloid-Derived Suppressor Cells and Treg Cells in Tumor Microenvironment via IL-17 Pathway in Murine Hepatocarcinoma Model CCL22 MMP9 CCL2 PMC7764352__F7 STRING: AML associated enriched pathways among the top 94 identified drug targets TFRC SOST USP4 RPSA POLE PMC7840718__F3 Wnt growth factor triggers macropinocytosis by binding to co-receptors Frizzled (Fz) and LDL receptor-related protein 6 (Lrp6) on the cell surface PRMT1 PAK1 APC GSK3B LRP6 CTNNB1 PMC11118937__F1 Nrf2 signaling in mitigating heat stress and xenobiotic-induced oxidative distress and apoptosis KEAP1 PMC8751739__F8 Suppressive effects of dental pulp stem cells and its conditioned medium on development and migration of colorectal cancer cells through MAPKinase pathways BAX FAS BCL2 CTNNB1 PMC7644630__F2 TBK1 and Innate Immune Signaling TBK1 CGAS MAVS TLR3 TLR4 RELA TANK RIPK1 IRF3 OPTN MYD88 PMC7840718__F1 Cancer cells ingesting extracellular small particles, such as protein, necrotic debris, and ATP, through macropinocytosis CDC42 PAK1 EGFR PTEN MTOR RAC1 PMC7840718__F2 Growth factors stimulation induces the PI3K/Akt/mTORC1 pathway RHEB TSC2 TSC1 PMC4400645__F1 PI3K Pathway Balances Self-Renewal and Differentiation of Nephron Progenitor Cells through Beta-Catenin Signaling FAT4 WNT9B CTNNB1 PMC6008200__F7 Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research CDC42 BAD CALML6 GSK3B ZNF274 CALML4 MAP2 PSEN1 SH2B2 TRAF6 NGF PLCG1 NTF3 PLCG2 PDPK1 NFKBIE ATF4 HEL2 CALML3 BAX FRS2 CRKL MAPKAPK2 ARHA RAC1 CRK SORT1 MAP3K1 FOXO3A PSEN2 MAPK7 NFKBIA MAP2K5 GRB2 BDNF NFKBIB PMC2858667__F1 Endocannabinoids Differentially Modulate Synaptic Plasticity in Rat Hippocampal CA1 Pyramidal Neurons CA3 C2 PMC8192250__F1 Mechanisms linking gut microbial metabolites to insulin resistance PRDM16 TRPV1 PCK1 IRS1 PMC9362167__F4 Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective STAT3 NLRP3 MTOR PMC3138544__F1 Targets and therapies for B-cell non-Hodgkin's lymphoma (B-NHL) within the context of the 10 hallmarks of cancer and overlapping oncogenic signaling pathways RHEB CSA2 BTK LYN MTOR PMC9248984__F3 Targets for limiting DC maturation / activation CD40 CD80 SGK1 TNLG8A CCR7 PMC4254517__F2 Anti- and pro-apoptotic roles of RIPK1(A) Upon TNFR-1 ligation RIPK3 CASP8 TRADD MLKL RIPK1 TRAF2 FADD PMC7069528__F1 Effect of cannabidiol (CBD) in Parkinson's disease and Alzheimer' disease (AD) GFAP TRPV1 APP FAAH IL1B S100B PMC3295030__F1 Simplified description of the insulin/IGF-1 signal transduction (IIS) pathway in invertebrates and mammals FOXO4 AKT3 IRS4 PTEN GRB2 FOXO6 IRS1 PMC2896944__F3 Hsp90 shelters aberrant neuronal proteins PINK1 LRRK2 GSK3B PMC5709276__F1 Pathway alterations in glioblastoma multiforme MDM4 CDKN2A CDK6 NF1 EGFR BRAF PTEN CDKN2B MDM2 MTOR CDK4 PMC10860821__F3 OA is a condition that involves the breakdown of cartilage in the joints NLRP3 ADAMTS5 IL1B PMC10860821__F1 Three types of pyroptosis pathway GSDMD NLRP3 TLR4 RIPK1 CMPK2 MYD88 PMC5836578__F5 Bioinformatic analysis of ATP-binding cassette subfamily A member 1 (ABCA1), revealing its preventive role in carotid plaque rupture and atherosclerosis progression during the inflammatory reaction NR1H2 NR1C1 NR1H3 FABP1 RXRA TBL1X RXRG NCOA1 ABCA1 PMC7290603__F3 Impact of tumor-derived EVs in Cancer Therapy Resistance HEL-S-22 TP53INP1 CTNNB1 PMC123677__F3 The action of S-phase checkpoints in the suppression of spontaneous genome instability RFC4 RFC2 MRE11A PCNA RFC3 DDC DRC1 PMC4553792__F3 Inactivation of DPH5 induces NFKB and death receptor pathways STAT3 EGF JUN SP1 IRF1 TNF IFNG STAT1 NFKB1 RELA IKBKB NFKBIA CREBBP EP300 CREB1 IL1B PMC6478864__F1 Wee1 inactivates Cdk1 by phosphorylation at tyrosine 15 CDC2 RRM2 WEE1 CCNB1 PMC7064006__F13 Possible metabolic pathway maps associated with the lipid biomarkers in dampness-heat induced diarrhea and dampness-heat induced diarrhea with PD treatment LPA PGP CERS1 PC PMC7503462__F1 Schematic description of tryptophan metabolic pathways with assigned physiological roles and regulatory points of select metabolites KYNU KMO ASMT IL1B IDO2 PMC8924449__F9 Transcriptomic and Metabolomic Analyses Reveal Key Metabolites, Pathways and Candidate Genes in Sophora davidii (Franch.) Skeels Seedlings Under Drought Stress HPD XDH MAP2K1 PRODH PRR7 ELF3 PMC3557440__F4 Schematic overview of the homologous recombination (HR) pathway RAD50 RAD51 MRE11A PMC9169637__F7 Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells’ response to Pten deletion PTEN MTOR CXCR4 OCM PMC11430608__F1 Mechanism of development of AP STAT3 IL6 TNF PMC7353012__F3 Functions of UCA1, lincRNA-ROR, and lncRNA MIR2052HG in the tamoxifen resistance of breast cancer LMTK3 EZH2 MTOR CTNNB1 DUSP7 PMC12000292__F4 ANXA2 inhibits tumour cell apoptosis and its effects on tumour immunity FAS NLRP3 ULK1 ANXA2 FADD PMC7353012__F4 Functions of GAS5, DSCAM-AS1, and Eleanors in the tamoxifen resistance of breast cancer PTEN PMC4069315__F1 Mechanisms of action of lactic acid bacteria via extrinsic and intrinsic pathways of apoptosis FAS BAK1 TNF PMC3384717__F9 Androgens up-regulating PCa cell proliferation via p66Shc-ROS signal pathway ERBB2 GPX1 PMC4069315__F2 Immune responses induced by lactic acid bacteria LTA IL16 PMC6893972__F7 Neuronal molecular pathways indicate glutamate and dopamine receptor signaling, in a representation of 45-day cerebral organoid proteomes TH GLS PSD PMC7747855__F7 Astrocytic SHH signaling pathway regulates BBB integrity after ICH SHH SMO PMC7356355__F1 Intoxification Pathway EGF IL2 PMC8844822__F1 SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites SARM1 NAMPT NMNAT2 PMC9446157__F2 Calcium signaling in cancer metastasis to bone TRPM7 HEL-S-43 STIM1 TRPV2 IGFBP1 TRPC1 IGF1R NFATC3 SRC TRPV6 PMC8127498__F8 Tissue-specific transcriptome analyses reveal candidate genes for stilbene, flavonoid and anthraquinone biosynthesis in the medicinal plant Polygonum cuspidatum PMVK MVD MVK PMC6001756__F1 Estrogen receptor (ER) signalling pathway TF SP1 EGFR ERBB2 SRC MYC PMC12000292__F2 ANXA2-induced autophagy inhibits apoptosis in tumour cells STAT3 ULK1 S100A10 ANXA2 TFEB PMC3310197__F7 Interactions of signaling by ER stress, oxidative stress, and cytokines with the pathways of autophagy: Induction of autophagy requires the assembly of Beclin-1 with class III PI 3 kinase (Vps34) and UVRAG ATG10 ATG3 ATG12 UVRAG MTOR PMC4826689__F1 Canonical Wnt signaling pathway (Beta-catenin-dependent Wnt signaling pathway) DKK1 APC GSK3B AXIN1 LRP5 LRP6 CTNNB1 PMC4826689__F2 Noncanonical Wnt signaling pathway (Beta-catenin-independent Wnt signaling pathway) APC NLK CTNNB1 PMC4613338__F1 Glutamine metabolism and potent targets for cancer therapy SLC7A11 SLC7A5 MTOR MYC PMC5402045__F2 ST2/IL-33 signaling pathway IL33 TLR9 IRAK1 IRF1 FOXP3 TRAF6 GATA3 MYD88 PMC9107211__F3 Incidence and immunomic features of apyretic COVID-19 in patients affected by solid tumors: a prospective cohort study SYK CD81 CD72 RASGRP3 GSK3B CD22 BLNK CD19 BTK BCL10 BCR GC LYN GRB2 PMC5927707__F2 Involvement of ZMYND8 and demethylases in the DDR and cancer ZMYND8 GATAD2A KDM5A KDM5C ME1 PMC11813773__F2 Dual roles of SBAs in colon cells: anticancer and cancer-promoting effects MDM4 EBP EGFR MDM2 PMC11813773__F3 Anticancer effects of SBAs in Hepatocellular Carcinoma (HCC) and Pancreatic Cancer STAT3 BAX NDRG2 PMC8152700__F5 Cardiac fibrosis POSTN COL1A1 APC GSK3B LRP5 LRP6 COL3A1 PMC7352479__F3 Crosstalk among glycolysis, MAPK, and PI3K pathways BAX BAD HEL-S-133P HEL-S-162eP PTEN PFKL MDM2 PMC7352479__F1 Glucose metabolism HEL-S-133P HK2 HEL-S-162eP FBP1 HIF1A PFKL GPC3 PMC7352479__F2 Oxidative stress pathways RHEB TSC2 TSC1 KEAP1 MAF PTEN MTOR PMC3017081__F4 Cell cycle G1/S check point subnetwork ATR TGFB1 GSK3B SMAD4 CDKN2D CDKN2B SKP2 RB1 CDKN2A CKS1B PLAGL1 CDK6 CCNE1 ATM CCND1 CDK4 CDC2 TFDP1 TGIF2 NPAT HDAC1 UHRF2 CDKN1A CDK2 IFI27 GRB2 PMC5330121__F6 The interactive pathways of stress-responsive miRNAs and their targets MYB NFYA SPX PMC3017081__F3 Crosstalk between interleukin signalling pathways IL3 IL4 IL2 IL7 IL6 IL5 PMC6456508__F8 TLR4/NFKB pathway mediating miR-625-5p and COL1A1 in IDD pathogenesis BTK COL1A1 TIRAP TLR4 IL6 IL1B MYD88 PMC11430608__F3 Activated intracellular signaling pathways in acute pancreatitis and their inhibition by natural compounds STAT3 KEAP1 MLKL TLR4 MYD88 PMC9505822__F1 Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer TDP1 SSB IMPACT PMC9599866__F3 Targeting KRAS in PDAC: A New Way to Cure It? AURKA EGFR MTOR KRAS PMC4513356__F1 Wnt Signaling in Dendritic Cells: Its Role in Regulation of Immunity and Tolerance FOXP3 CTNNB1 PMC7705326__F1 Mechanism of action of possible anti-SARS-CoV-2 drugs on the interferon signaling pathway STAT3 TBK1 STAT2 IRF9 MCL1 TLR9 IRF1 IRF3 IRF7 MTOR TRAF3 MYD88 IFNG STAT1 TLR3 STAT4 JAK1 TYK2 PMC4163504__F1 Proposed molecular interaction between two neuropathologies such as major depressive disorder and Alzheimer’s disease CA3 APOE APP PMC3085438__F5 Working model for the role of CCN6 in breast cancer invasion WISP3 IGF1 IGF1R IRS1 PMC7999260__F3 Combination therapy for miR-21i and TMZ STAT3 BCL2 PTEN PMC7999260__F4 General principle of the HSV-TK suicide gene system ATM TNF FADD PMC7593559__F2 AAI can activate TGFB/Smad-independent signaling pathways to cause abnormal cell proliferation CYP1A2 TGFBR2 EGFR SMAD2 IL18 SMAD4 BCL2 GRB2 CYP1A1 TGFBR1 PMC3757404__F1 Wnt/Beta-catenin Signaling Pathway SOST APC LRP5 LRP6 CTNNB1 PMC3390257__F2 mTOR: from growth signal integration to cancer, diabetes and ageing RHEB TSC2 EIF4B TSC1 GSK3B PTEN YY1 SESN1 SESN2 IRS1 PMC9338659__F4 Frontier progress of the combination of modern medicine and traditional Chinese medicine in the treatment of hepatocellular carcinoma STAT3 BAX EGF EGFR MTOR ATG5 CCND1 PMC11520425__F1 Classic Wnt/Beta-catenin signaling pathway: mechanisms in closed and open states APC LRP5 LRP6 CTNNB1 PMC11520425__F2 Wnt signalling regulation of osteoblasts and osteoclasts MCC ROR2 LRP5 LRP6 PKN3 ARHA RHO SRC CTNNB1 PMC11575928__F2 Survival mechanisms of ovarian cancer spheroids in ascites HGF COL4A2 FZD7 NOTCH3 KRAS TWIST1 PMC11575928__F3 TAMs in spheroid formation, survival and metastasis EGF VEGFC CCL18 EGFR CCR5 ARG1 MMP9 CD47 POSTN CD24 HBEGF UBR5 SIRPA CD163 GPT PMC1600679__F7 Summary of changes in the Wnt/Beta-catenin pathway in pancreatic adenocarcinoma FZD2 APC GSK3B CTNNB1 PMC9252752__F7 Inhalation of Salvianolic Acid B Prevents Fine Particulate Matter-Induced Acute Airway Inflammation and Oxidative Stress by Downregulating the LTR4/MyD88/NLRP3 Pathway NLRP3 IL16 TLR4 TRAF6 MYD88 PMC2760938__F13 Regulation of Lysophosphatidic Acid-induced Epidermal Growth Factor Receptor Transactivation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells by Protein Kinase CD, Lyn Kinase, and Matrix Metalloproteinases LPA HBEGF EGFR LYN PMC3395887__F3 Interaction of pathogen recognition and ST2 receptor systems with FcERI leads to substantial enhancement of production of cytokines and chemokines TLR3 TLR4 IL33 ATF2 TRAF6 IRAK4 MYD88 PMC3348998__F1 Lipids and Prostate Cancer ACLY HEL60 HMGCR SCD HK2 FASN ME1 ACACA HEL-S-26 PMC10473156__F3 DNA Damage Response-Associated Cell Cycle Re-Entry and Neuronal Senescence in Brain Aging and Alzheimer’s Disease ATR RAD50 RAD51 MRE11A DNA2 BLM PMC5398881__F6 Scheme showing hyperglycemia-induced VEGF expression regulated by PRR, RAC1, and miRNA signaling LOX PTEN HIF1A SPRY1 RAC1 PMC3035994__F1 Simplified model of nutrient signaling pathways influencing metabolic responses RHEB TSC2 TSC1 PTEN PMC5891886__F3 Epithelial proteomic networks for TRIM28 high (a) and low (b) ratio cases BAX TRIM28 RUNX1 EGFR SPHK1 MTOR LCK PMC7562735__F10 Distribution of targets of KGEC on the comprehensive signaling pathway SYK BAD TRADD SGK1 LAT MMP9 MTOR TNF SGK2 BCR COX2 TLR4 MMP3 IL2 BCL2 VCAM1 LCN2 GRB2 TRAF2 BIK CDK4 FADD PMC4905361__F2 TNFR1 signaling CAP2 SHARPIN TRADD TAB3 RIPK1 TNF CAP1 CYLD PMC8086570__F5 Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses NCALD TRIM9 MBD6 WDR4 GSC TWIST2 ZEB2 PMC7504541__F9 Hypothetical role of IL-6 in oncogenesis and tumor-associated thrombocytosis STAT3 ADAM17 TPO PMC419721__F7 Schematic model of signaling events to MEKs and Erks induced by threshold concentrations of Epo GSK3A EPOR GSK3B EPO PMC5746087__F7 miR-564 inhibits hepatocellular carcinoma cell proliferation and invasion by targeting the GRB2-ERK1/2-AKT axis BAD HEL-S-28 PTEN MTOR CTNNB1 EIF4E RHEB TSC2 TSC1 CDC37 MDM2 GRB2 CCND1 PMC7915065__F1 Signaling pathways and factors involved in programmed cell death ligand-1(PD-L1)-induced resistance STAT3 EGFR YAP1 PMC7915065__F2 Key mechanisms underlying resistance to PD-L1 (1) CD80 NLRP3 HHLA2 YY1 IL8RB JAK1 LAG3 PMC4744516__F1 Long noncoding RNAs in viral infections MAVS TRIM25 IFITM3 IFITM1 IRF3 ISG15 EIF2A PMC4050248__F7 Protein kinase C epsilon (PKCɛ) is a major regulator of mitochondrial nicotinamide phosphoribosyltransferase (Nampt) and nicotinamide adenine dinucleotide (NAD) NAMPT HIF1A NMNAT3 PMC6537414__F6 Functional analyses of five core clusters PRLR STAT3 RAF1 MCL1 PIK3R1 IL2RG SOCS3 MTOR MYC CSF3R BCL2L1 GHR PIM1 PTPN11 PTPN6 HRAS GFAP IL2RB CDKN1A PIAS1 BCL2 EP300 IL6ST JAK1 GRB2 CISH PMC10458946__F6 STING signaling pathway inhibition by STINGB in various ways and at various steps TBK1 CGAS PMC11452178__F9 The regulation of muscle phenotypes by MSTNDel73C mutation with FGF5 knockout MYOD1 GDF8 FOSL1 MYMX MYMK PMC3475613__F2 Schematic illustrating metabolic pathways prominent in malignant cells MAX FH HEL-S-133P HK2 MPC1 MPC2 MYC HEL-S-26 PMC9640569__F6 Genomic control of inflammation in experimental atopic dermatitis TSLP IL33 VEGFA PMC9526899__F3 Omega-3 supplementation on components of the endocannabinoid system and metabolic and inflammatory responses in adipose and liver of peripartum dairy cows TG DAGLA MLXIPL FASN FABP4 IL6 MGLL PMC7673069__F1 Schematic presentation of the life cycle of SARS-CoV-2 in the host cell and proposed sites of famotidine action TMPRSS2 HEL-S-69p ACE2 PMC9376585__F5 Pyroptosis in inflammation and cancer P2RX7 CARD8 IL10 GSDMD NLRP3 IL18 DFNA5 PMC4107230__F6 Different mechanisms of signaling for EMT which might be induced by FGF10 CDH2 TIMP1 APC GSK3B CDK2 MTOR FGF10 PMC7814631__F6 Cell signaling pathways in the epigenetic regulation of myogenesis ACTN1 MYOG CARM1 IGF1 MYF5 EZH2 YY1 PAX7 CTNNB1 PMC7967207__F1 Tannic acid (TA) acts as a repressor for multiple proteins essential in several oncological signaling pathways STAT3 EGF EGFR SMAD2 LIF SOX2 SMAD4 TGFBR1 PMC7945216__F7 Mechanism graph of the regulatory network and function of FoxM1-mediated miR-335-3p in NSC self-renewal FOXM1 CDK2 CDK4 FMR1 PMC2259464__F2 TGFB signaling pathway SMAD2 SMAD4 PMC8750186__F4 mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells RB1 PSMB6 FH TFDP1 PSMB3 E2F4 E2F3 TFDP2 PSMD13 PMC5885760__F2 Microbiome series CUTC PMC8044581__F10 MicroRNA-1297 suppressed the Akt/GSK3B signaling pathway and stimulated neural apoptosis in an in vivo sevoflurane exposure model BAX GSK3B PTEN PMC5531511__F3 Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort KLF2 INSR BNIP3 CDK2 ATM HEL-S-11 MDM2 NLK SKP2 INS PMC7878388__F1 HSV manipulations on the cytosolic pattern recognition receptors TBK1 CGAS MAVS AIM2 IFI16 CTNNB1 PMC5531511__F4 Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort AFP PATJ APC PMC4800863__F5 Schematic illustrations of l- and d-proline metabolism in Sinorhizobium meliloti PROB1 PROC PMC2704572__F1 Complement effectors generated during activation contribute to various mechanisms that limit tumor growth MASP1 MASP2 HEL-S-62p C2 C4A C4B_2 PMC7884467__F1 NLRP3 inflammasome pathway GSDMD NLRP3 KL PTMS FADD PMC2704572__F2 Some complement proteins can accelerate tumor growth MASP1 FH MASP2 C2 C4A C4B_2 PMC6434430__F2 ERK signaling pathway was hyperactivated in the patient’s tumor tissue ZAP70 JUN BAD DDR1 LAT EGFR KIT MYC KRAS FOS PDGFRA RAP1A NTRK1 ATF1 GRB2 RET CSF1R PMC5384838__F1 Vesicular acetylcholine transporter defect underlies devastating congenital myasthenia syndrome ACHE MUSK LRP4 ALG2 GFPT1 ChAT DPAGT1 ALG14 SCN4A COLQ PMC4709758__F9 Signaling pathways of IL-17A in synovial fibroblasts TRADD RELA TRAF5 IRAK1 TRAF6 TNF TRAF2 MYD88 PMC9483202__F3 Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases UCP2 KEAP1 GSK3B PTEN SIRT1 PMC6295097__F7 Proposed pathway of anti-tumor effects of propofol on lung cancer A549 cells MTOR CTNNB1 PMC3712618__F4 Putative PGC-1-mediated mechanism of cancer-induced skeletal muscle wasting IGF1 MTOR IRS1 PMC4735260__F6 Transcriptional regulation of mitophagy CITED2 SP1 BNIP3 ATF4 FUNDC1 PMC6193900__F1 Signaling pathways and regulatory nodes that indicate novel therapeutic approaches for KRAS mutant NSCLC STAT3 TBK1 FRS2 KEAP1 ECT2 KRAS RAC1 YAP1 CDCP1 ERBB3 PAK1 FGFR1 WEE1 SRC HES1 FSTL5 PMC9170780__F4 Bone pain: Progress in research from bench to bedside DCC MSC ARHA PMC6508148__F3 Proposed models of CST1 participating in the signaling pathways.Notes: CST1 was involved in GSK3, AKT, and IL-6 pathways GSK3B CST1 PMC8106556__F1 Targeting the alternative bile acid synthetic pathway for metabolic diseases FGF8A CYP8B1 CYP7A1 FGFR4 CYP7B1 CYP27A1 PMC8106556__F2 Targeting the alternative bile acid synthetic pathway for metabolic diseases FAS ABCG8 AKR1D1 ABCG5 CYP8B1 CYP7A1 CYP7B1 CYP27A1 ABCA1 PMC3978875__F6 Proposed signalling interactions between C-type natriuretic peptide (CNP) and mechanical loading in chondrocytes CSK NPR2 CNP IL1B NPRC PMC11781175__F8 AS III induces autophagy and activates the nuclear translocation of Nrf2, resulting in the accumulation of p62 and autophagic flux blockade KEAP1 MAF YAP1 PMC7453787__F2 BMP-SMAD pathway and hepcidin regulation in different iron states BMPR2 BMP6 TFR2 ACVR2A BMP2 HAMP HFE FURIN TMPRSS6 HFE2 PMC7453787__F4 Crosstalk between inflammation and the BMP-SMAD pathway in hepcidin regulation BMPR2 STAT3 BMP6 ACVR2B ACVR2A BMP2 HAMP HFE2 PMC6354897__F1 Key pathways interacting with theMEP pathway in chloroplast LOX C2 CS PMC7918730__F3 Clock and mTOR pathway interconnection TSC2 MTOR PMC4750108__F1 Working model of the innate immune sensing of tumors leading to spontaneous T cell responses in vivo TBK1 CGAS IRF3 PMC11117976__F3 NETosis in neutrophils TXNIP IL8RB PMC11117976__F5 M2 macrophage polarization PRX ARG1 IRF4 HEL-S-44 MPO PMC11117976__F1 TLR and NOD receptor-mediated immune response MAP3K7IP1 RIPK2 NLRP3 TXNIP NOD2 NOD1 TRAF6 PMC7005297__F1 Wnt/Beta-catenin pathway in cancer stem cells DACT1 MMP7 APC PMP22 SMYD3 GSK3B LRP5 LRP6 EZH2 TERT MYC HOXA5 CD44 TIAM1 DKK2 GPR49 TEF PMC7005297__F2 Hedgehog signaling pathway in cancer stem cells GALNT1 FBXL17 USP48 RUNX3 BMI1 CD44 PRKCI SUFU PTCH1 FOXC1 SHH SMO TWIST1 CCND1 BCL6 HDAC6 PMC8508937__F3 ERB Regulation of Gonadotropin Responses during Folliculogenesis APPL1 FSHR LHCGR PMC7005297__F3 Targeting cancer stem cell pathways for cancer therapy BMI1 CD44 CD40 TNFRSF19 CCR7 FOXP3 PMC3986830__F1 DREAM complex: Master coordinator of cell cycle dependent gene expression LATS1 FOXM1 LATS2 FBXW7 DYRK1A CDK2 CDK4 PMC11117976__F8 Immune suppression during bacterial infection CA12 NLRP3 TXNIP PRX PMC7177584__F3 PRDM proteins participation in signal transduction pathways, proliferation, and gene expression regulation CEBPE PRDM8 JUN PRDM5 INCA1 PRDM14 PRDM13 PRDM1 PRDM11 SMAD2 APC PRDM16 GSK3B MTOR FOS SKI IRS1 CTNNB1 DKK1 SERPINB2 ADAMTS12 PMC6095988__F2 Androgen signaling pathway in granulosa cells of the primordial follicle HEL-S-99n SHBG SRY NCOA1 TBP SRC PMC7177584__F1 PRDM proteins contribution in the mechanisms related to invasiveness and metastasis FYN TIMP1 PRDM14 PRDM13 PAK1 PRDM1 ARHGAP30 RELB PRDM2 MMP2 ERBB2 BMP5 PMC3707302__F3 Immunological synapse: the gateway to the HIV reservoir ADAM17 NUMB ADAM10 PMC5427056__F1 Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy RHEB EIF4B TSC1 SGK1 NF1 FOXO1 ULK1 PTEN HP DEPTOR IRS1 EIF4E PMC5464113__F2 Genes found to modulate the accumulation and secretion of different aggregated species of aSyn RAB27A RAB11A RAB13 RAB8B PMC8725311__F2 Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier JUN BAD MYC PMC5688955__F1 Diagram showing the various effects as well as the different pathways activated by ouabain in ADPKD cells BAX EGFR CFTR SRC PMC6221947__F1 Polyamine Pathway and Reaction Mechanism of DHS EIF5A DAP DOHH PMC8630681__F8 Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway TF HMOX1 SLC3A2 FER GPX4 PMC4016715__F2 Ciliary-vesicle-dependent steps of ciliogenesis, and modular organization and mechanism of the IFT machinery RAB14 IFT46 BBS1 IFT140 IFT172 IFT74 IFT80 IFT52 IFT22 TPR IFT43 RAB15 RAB12 BBS9 BBS7 IFT57 IFT81 BBS5 BBS4 IFT20 IFT25 PMC4016715__F3 Model depicting ciliary cargo trafficking pathways CEP290 RPGR PCM1 RP2 BBS4 IFT20 ARF4 ARL6 ARL3 NPHP3 UNC119 PMC9376585__F1 Pyroptosis in inflammation and cancer NLRC4 NLRP1 GSDMD NLRP3 AIM2 PMC9376585__F2 Pyroptosis in inflammation and cancer CGAS PINK1 GPX4 PLK4 IRF7 CARD8 NLRP1 DPP9 PLCG1 NLRP3 ELANE DDX3X EIF2AK2 IL1B PMC6696194__F8 Signaling pathway for GSSA via SCARB1 receptor from CD19+ lymphocyte SYK BCR BLNK LYN PMC9500586__F3 Personalized nutrition: A review of genotype-based nutritional supplementation ALDH1A3 HEL-S-53e ALDH1A2 DHRS3 PMC11892138__F7 Eugenol accelerates intestinal stem cell regeneration to protect the intestinal barrier integrity through inhibiting JAK2/STAT3 signaling pathway in Salmonella enteritidis-challenged broiler chicks STAT3 GPR49 PMC6761967__F5 Whole driver PC3-represented PCa signaling pathway PARVB DKFZp434N041 GRINA RELB SMAD2 ORC1L PMAIP1 MTOR LPA ADRA1B HSPD1 CACNA1I TUBB2A SHC3 TFDP2 SIAH1 F2RL3 BLNK TNF SNRPN CBL HEL-S-125m PTCH2 CSK LEF1 SNRPA1 PMC6829248__F2 Summary of natural product regulation in proteostasis machinery RB1 MDM2 MTOR PMC3443258__F6A An inventory of peroxisomal proteins and pathways in Drosophila melanogaster AGPS GNPAT HEL-S-5 PMC8834581__F3 Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle GC SRC HCTP4 PMC6305227__F1 Propionibacterium acnes: loss of diversity, selection of phylotypes, and its different target activities in acne CD44 CRH PMC6639256__F7 READ pathways (p53 signaling pathway, intestinal immune network for IgA production, and colorectal cancer pathway) enriched in DEmRNAs during READ BAD APC ATM PMC3329340__F3 Simplified TOR signaling network with known Arabidopsis homologs in Italic writing MLST8 TSC2 RICTOR TSC1 PMC5469033__F1 Adipose Tissue NAD+ Biology in Obesity and Insulin Resistance: From Mechanism to Therapy SIRT3 NRK SIRT7 NAPRT SIRT4 SIRT5 NAMPT SIRT2 SIRT1 SIRT6 PMC9928999__F2 Regulatory effects of oral microbe on intestinal microbiota and the illness TJP1 TLR4 S100A9 CCL20 PMC8419056__F3 Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment HMGB1 NLRP3 TLR4 EGFR GSDMB TNF PMC8419056__F2 Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment STAT3 BAX HMGB1 NLRP3 GSDMC PMC5079533__F4 Ingenuity pathway analysis of endocrine networks depicted in through NR1i1 BGLAP TRH CYP24A1 SLC34A1 LEP UCP3 LEPR AIP RXRG INS SPP1 FGFR2 CASR GNAS REN INSR FGFR1 ADRB2 APLN KL CALCA ACE2 PMC7577320__F1 Malic Enzyme 1 (ME1) in the Biology of Cancer: It’s not Just Intermediary Metabolism ACLY ME3 HEL-S-133P ME2 FASN PMC3472558__F1 EGFR signaling pathway (reprinted with permission from BioCarta Pathways STAT3 EGF RAF1 GRB2 JAK1 FOS PMC10644365__F2 Signaling pathways associated with ERA TF RHEB TSC2 TSC1 APC PTEN GRB2 MTOR CTNNB1 PMC4688235__F2 Recent advances on viral manipulation of NFKB signaling pathway CGAS MAVS TLR3 TLR9 IFI16 TLR7 CCL5 MYD88 PMC6293255__F5 Top two networks (A and B) identified by Ingenuity Pathway Analysis as overrepresented within the list of 245 genes (P < 0.005) dysregulated in human IAPP transgenic (HIP) vs GABBR1 RAMP3 PPARG ATF3 NPAS2 SERPINE2 PLAUR TP63 SERPINB2 CCL2 FOS PMC6277408__F4 Analysis of p53-pathway in relation to miRNA expression and potential targets BAX CASP9 CASP3 PMC8631789__F5 Overt Acute Hepatitis B Deteriorates in Females: Destructive Immunity With an Exaggerated Interleukin-17 Pathway IFNG IL4 PMC2494844__F2 Genomic dissection of the cytokine-controlled STAT5 signaling network in liver SOCS2 SOCS3 GHR PMC3089989__F2 Gene expression pattern of the P38 MAPK signaling pathway MAX MAPKAPK2 MAPKAPK3 TIFA TRAF2 PMC4688235__F1 Recent advances on viral manipulation of NFKB signaling pathway CGAS TIRAP MAVS TAB3 TLR9 IFI16 CCL5 TRAF6 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 DDX41 TLR8 TLR7 FADD PMC9102649__F4 Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non‐small cell lung cancer cells via p53‐p21 signaling pathway CDK6 CDCA5 CDK2 CDK4 PMC9460126__F7 Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation ULK1 MTOR VASN PMC11795593__F7 Transcriptomic and metabolomic-based revelation of the effect of fresh corn extract on meat quality of Jingyuan chicken SPHK1 SGMS2 CERS6 PMC7136521__F1 Angiogenic and vasculogenic mimicry promotion by CSCs is mainly triggered by VEGF among several types of cancer STAT3 FZD2 DKK1 CCR3 CD34 PMC11989355__F4 KEGG pathway diagram POR TH HEL-S-11 PMC4088997__F5 Rapamycin and paclitaxel nanoparticles synergistically target the PI3K/Akt/mTOR pathway by suppressing feedback loop Akt phosphorylation BAD PTEN IRS1 PMC5687841__F6 Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis ZAP70 EGF LTA TGFA LTBR TIRAP SPHK1 RELB TAB3 SDC4 MGLL TNF VCP MYD88 NGF RELA SERPINB2 REL LCK PMC5474292__F3 Nodes linking the enriched KEGG pathway by hub genes PPARG NOS2 JUN EGFR NFKB2 RPS6KA2 IL4 PTK2B PLK1 MYC FOS IRS1 BTRC TK1 MAP2K6 INSR PRL MYH9 GADD45B EDNRB CDK2 MDM2 LMNA PMC4614816__F1 Cells express exosomes comprising lipids however lipids impact on cancer cells according to cell phenotype PTEN CXCR4 NOTCH1 PMC9354757__F1 Profile of Glasdegib for the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML): Evidence to Date SUFU SMO GLI3 PMC9406051__F9 Genomic Aberrations Generate Fusion Gene FOXK2::TP63 and Activate NFKB1 in Cutaneous T-Cell Lymphoma HID1 CAMK2D NFKB1 UBE2D3 IRF4 RBPJ PMC4107453__F8 Role of the SIK2-p35-PJA2 complex in pancreatic beta cell functional compensation TSC2 PJA2 CDK5 SIK2 PMC3634440__F1 Gene regulatory networks of plant transcription factors (TFs) in plant abiotic stress responses and abscisic acid-dependent gene expression MYB ERF SNRK PMC9352922__F3 PKCA and PKCD: Friends and Rivals CDC2 CDK2 MTOR SRC CDC25B CDK4 PMC6425079__F1 Schematic diagram depicting proposed mechanisms responsible for aniline inducedspleen toxicity OGG1 NEIL2 NEIL3 NEIL1 IL1A PMC10995224__F2 Signaling pathway that was affected by ridaforolimus TSC2 PHLPP1 PHLPP2 PTEN MTOR DEPTOR PMC9304707__F2 What we have learnt from Drosophila model organism: the coordination between insulin signaling pathway and tumor cells HDAC3 EGFR EIF4E PMC12037492__F1 Mechanisms via which TYMP promotes platelet activation and osteoclast differentiation SYK FYN NFATC1 LYN TRAF6 TYMP PMC4770095__F2 Regulation of Th2 Cell Immunity by Dendritic Cells KLF4 CD40 CCR7 IRF4 IRF8 PMC2731164__F7 Embryonic Stem Cell Differentiation TNFRSF10B BUB1B IRAK2 PLK1 MYD88 RB1 SMC1B E2F4 MDM2 APAF1 ESPL1 CASP8 CASP12 SMC1A CDKN1A CDKN1B DFFA MCM3 MCM5 CDK2 MCM6 MCM2 CDC25B BAD FAS TRADD CDC20 TNFRSF1A CDC6 SFN CDKN2D CDKN2B MAP3K14 IL1R1 CASP6 CDK7 CCND2 IRAK3 CHEK2 CHUK RIPK1 ATM BIRC3 DBF4 CCND3 BAX DFFB RBL1 HDAC1 PKMYT1 FZR1 PRKDC RELA CHEK1 NFKBIA CREBBP PMC12037492__F3 Mechanism via which TYMP modifies epigenetic and resists apoptosis TYMP catalyzes the conversion of thymidine to thymine and 2DDR, which binds to integrin AVB3/A5B1 on progenitor cells, thereby activating the PI3K pathway MDM2 IRF8 RUNX2 TYMP PMC5321802__F2 Regulation of hepcidin expression in hepatocytes in response to iron status and requirements (left) or inflammation (right) STAT3 BMP6 JAK1 HFE2 PMC9326259__F9 Mechanism and Molecular Targets of Ejiao Siwu Decoction for Treating Primary Immune Thrombocytopenia Based on High-Performance Liquid Chromatograph, Network Pharmacology, Molecular Docking and Cytokines Validation VWF FH CPB2 HEL-S-62p TFPI CR2 F11 F8 CD19 CS PMC8113755__F1 WNT plasma membrane signaling in PDAC TSC1 RNF43 PORCN APC GSK3B LRP5 LRP6 MTOR MYC GPR49 CTNNB1 PMC6493202__F6 Neuroprotection by Sildenafil NGF PTEN ARHA BDNF PMC7408575__F2 JAK-STAT canonical signaling pathway IL19 IL24 EPO TPO PMC5703970__F3 C-T-P network NOS2 GRIN2B NTSR1 HTR2A PTGS2 MMP9 TNF AGTR2 F2 HEL-S-102 PTGS1 CALM1 PBR MMP2 APP ADCY1 PMC5703970__F4 Neuroinflammation pathway and therapeutic modules CDC42 PLN NOS2 BAD HTR2A PTGS2 LOX GNRHR HEL-S-102 PTGS1 CASP3 MMP2 APP ADCY1 SRC PMC7795265__F6A Proteomic Profiling of the First Human Dental Pulp Mesenchymal Stem/Stromal Cells from Carbonic Anhydrase II Deficiency Osteopetrosis Patients GNAI3 S100A4 KDM3A AIP PCOLCE YBX1 MB PLOD2 GLB1 FERMT2 PMC9646750__F1 Advances in multi-omics study of biomarkers of glycolipid metabolism disorder TCF7L2 PNPLA3 ABCC8 DPP4 CTNNB1 PMC3003706__F7 Distinct B1 and B3 integrin pathways converge to regulate cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells TRIO SRC CD47 RAC1 PMC478571__F3 Chart of cell cycle genes PCNA CDC6 ORC6 CCNA2 ORC3 SKP2 ORC2 CCNH RB1 CCNE2 CDK7 CCNE1 CDC45 MCM3 CDK2 MCM5 MCM6 POLD4 MCM2 CCND1 CDK4 PMC4232069__F2 A FOXO3-driven pathway abrogates inflammatory responses in a transforming growth factor (TGF)B1-dependent manner TGFB1 FOXO3A IL1B PMC8082541__F1 Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue NR1C1 PRDM16 TRPV1 UCP1 ATF2 TRPM8 SIRT1 PMC8616505__F2 Interplay between the Unfolded Protein Response, Inflammation and Infection in Cystic Fibrosis NFIB ELF2 ATF4 XBP1 TRAF2 PMC7798015__F4 Direct and indirect intracellular effects of CCN proteins in chronic myeloid leukemia (CML) CCN4 BAX CYR61 NFKB1 CCN3 CTGF NOTCH1 PMC8299052__F4 MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1A/SIRT3 Signaling Pathway SIRT3 MCU PMC7798015__F2 Complex regulation of CCN2 expression, and the diverse actions of the CCN2 protein, as reported in literature GDF5 VWF IGF2R DCSTAMP EGFR CCN3 RHO CTGF PMC8299052__F1 MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1A/SIRT3 Signaling Pathway MICU1 MCU MCUB EFHA1 C6orf79 PMC9695228__F11 Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core ADRBK1 CDON BOC SUFU GSK3B SMO GAS1 KIF27 PMC11520086__F3 Metabolic pathway and enzyme gene expression difference of C1 compounds in the transcriptome group, Formaldehyde vs HYI GAR1 GCK CIT PMC7010578__F4 Major pathways and genes related to major depressive disorder (MDD) TGFA FRS2 NTRK2 GRIK2 CRK DRD1 DRD2 MALL NTRK1 CASP3 ERBB2 GRB2 BDNF PMC6186337__F1 In this figure, we consider potential mechanisms regulated by physical activity and caloric restriction in inhibiting the mTOR pathway IGF1 IGF1R MTOR PMC3657575__F10 The signaling pathways involved in calpain-mediated regulation of dendritic protein synthesis induced by BDNF PTEN MTOR BDNF PMC5635727__F2 Lut alleviates I/R injury by inhibiting apoptosis by up-regulating AKT, increasing BCL-2 protein and decreasing BAX protein PLN BAX KEAP1 HEL-S-69p PMC6323179__F6 Proteome changes in (A) G-protein signaling pathway, (B) calcium signaling pathway and (C) ginsenoside synthesis pathway and (D) ribosomes biogenesis, ubiquitin-mediated proteolysis and RNA transport pathway NUP155 RAN IPP RPN2 ELF2 PC EIF5B ELF3 PMC8953452__F1 HOG pathway and the regulation of osmoadaptive responses in yeast TF CIB4 C6 CIB3 MRC1 CIB2 C2 PMC5390025__F2 Host-Helminth interaction: There are two sides of immune response against a parasite invasion, one leads to worm survival in host and the other to worm killing IL25 IL33 ARG1 PMC7830946__F7 Nuclear factor erythroid 2 (NEF2)-related factor 2 (Nrf2) signaling pathway of oxidative stress KEAP1 PMC3110895__F4 Modeled miRNA mediated pathways in the pathogenesis of lung fibrosis BAX FAS APC TNF PMC2634254__F2 Embryonic liver development ALB PROX1 HGF NR2A1 AFP BMP4 FGF2 PMC4013402__F1 Glucose and glutamine metabolism in cancer cells SLC7A1 GLS SLC5A1 PMC2634254__F4 Upstream regulators and downstream targets of Beta-catenin during embryonic liver development SFRP5 BMP4 FGF10 CCND1 CTNNB1 PMC4889573__F2 cAMP intracellular signaling pathways in target cells of Treg suppression CD83 CD80 NFATC1 PMC4138319__F3 miRNA- and TF-mediated sub-network specific to the TGFB signaling pathway MMP14 ANAPC7 SLC38A1 IRF1 ATP2A2 STK39 TGFBR2 MAGI3 FRMD6 SYNPO2 PDZD2 FZD4 CDK6 SPOCK2 TNS3 QK3 ITGB8 GCLC IL6ST YWHAZ CDK4 PMC7915382__F1 Aldosterone signaling pathway most significantly affected by oregano with 19 genes CRAT NEDD4 ICMT PMC7188969__F2 CD36 in Type 2 Diabetes Mellitus: Beta-Cell Dysfunction and Beyond NLRP3 TXNIP CD36 SRC PMC8042171__F2 Genetic glycoengineering in mammalian cells FUT3 ST8SIA1 B3GALT4 ST6GALNAC6 ST6GALNAC2 GALNT12 GCNT2 MGAT2 POGLUT2 ST3GAL5 B3GNT6 GALNT16 B4GALT5 GCNT3 PLOD3 ST3GAL3 GALNT10 RXYLT1 LARGE2 POGLUT3 CSGALNACT2 B3GLCT TMTC2 TMTC1 UGCGL2 TMTC4 LARGE ST3GAL6 ST8SIA5 ALG2 ST8SIA6 GXYLT1 B4GALNT2 GXYLT2 ALG3 B3GALNT2 ST8SIA2 EXT1 PIGV gcnt B3GNT3 B3GALT1 XXYLT1 SIAT4C COLGALT1 GALNT9 GALNT8 CHPF2 GalNAc-T18 PIGB B3GNT9 B3GNT8 B3GAT3 B3GNT7 B3GNT4 B3GNT2 PIGM ST6GALNAC4 B4GALT4 GCNT1 EXTL1 CHSY1 GCNT4 UGCG UGGT1 FUT1 GALNT5 FUT4 FUT8 FKRP FUT6 GALNT4 C1GALT1 FUT5 DPY19L1 POFUT2 DPY19L2 FUT7 DPY19L3 DPY19L4 POFUT1 GALNT6 ST6GALNAC1 LFNG MFNG A4GALT GALNT7 CSGALNACT1 C2 ABO XYLT1 ST8SIA4 OGT CHSY3 ST3GAL1 B3GAT1 TPO GALNT3 PIGA MGAT3 ALG13 TH MGAT5B MGAT1 MGAT4D STT3A GALNT1 GAL B4GALT1 CHPF UGT8 ALG8 B3GNT5 B4GALNT1 ALG10 ALG1 EXTL2 STT3B PMC7142254__F3 Targeting USP7-MDM2/MDMX-p53 network for cancer therapy GNE MDM2 PMC4259860__F7 Differential proteomic profiling unveils new molecular mechanisms associated with mitochondrial complex III deficiency APRT HEL113 HEL-S-107 HEL70 SNX6 HEL114 EIF3S3 MTHFD1 HEL-S-304 HEL-S-162eP DLD ENO1 HEL-S-87p HEL-S-64p PMC2888385__F6 Nodal-Smad2 signaling regulation of the BMP pluripotency pathway in mouse ES cells GATA2 NODAL ASCL2 FGF8 PMC3479343__F7 Placental PPARG Regulates Spatiotemporally Diverse Genes And A Unique Metabolic Network TG DGAT1 LDHB DCAKD PMC5831804__F1 Major players implicated in the phenotypes associated with the deletion of GUP1 in S CDC42 ROM1 SIM2 FAR1 ORM1 ORM2 PMC8891816__F2 miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review CDC2 STAT3 CDK6 CDK2 PTEN IL6 MTOR CDK4 PMC2538516__F1 Biosynthetic relationships between amino acids, as defined by their biosyntheses and their relationships with the glycolytic pathway and the citric acid cycle CGN UCN DAP GGN PMC9485267__F1 Targeting p85B nuclear translocation for the tumors with PIK3CA helical domain mutations DLG2 EZH1 EZH2 IRS1 PMC8153134__F2 Molecular Basis of Calcium and Phosphorus Inherited Metabolic Disorders NR1i1 CYP2R1 CYP27B1 CYP24A1 PTH CYP27A1 FGF23 PMC5827181__F2 Toward novel ways of MALT1 activation? TRAF4 BCL10 BCR TRAF5 TRAF3 TRAF6 TRAF2 PMC5827181__F1 The waves of MALT1 activation BCL10 CARD11 TRAF6 PMC9001993__F5 2-Methoxy-1,4-naphthoquinone (MNQ) regulates cancer key genes of MAPK, PI3K, and NFKB pathways in Raji cells BAD EGR1 TRADD NFKB2 LAMTOR3 BRAF PTEN KRAS FOS ARAF HRAS RB1 ITGB1 FOXO1 NFKB1 FOXO3A CDKN1B PMC6311529__F7 Proposed model of LUBAC-mediated ubiquitination on cFLIP in the TNFA receptor signaling pathway SHARPIN TRADD RNF31 TRAF5 RIPK1 TRAF2 FADD PMC4027966__F3 Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes GNG2 FRMD4B UTP18 KCNMA1 TPMT ATP6AP2 PMC5960485__F8 Network showing the most important gene interactions for the “regulation of canonical WNT signaling” (GO term GO:0060828) pathway DVL1 AGO2 CSNK1E AXIN1 LRP5 WNT1 LEF1 AXIN2 PMC7731198__F4 Novel mechanism of lysostaphin resistance in ST72 isolate and its associated metabolic pathway DHFR DHPS PMC6198057__F1 Scheme depicting the main upstream and downstream regulators of mTORC1 signaling pathway RHEB TSC2 TSC1 BCL2 GIP SIRT1 PMC7991912__F2 Pathway overrepresentation and gene ontology analysis of cisplatin-induced significantly deregulated proteins RPL35 RPSA RPS14 FASN RPL36 RPL13 RPL6 AARS1 ELF4 SH3BGRL3 RPL23A RPS20 RPL17 PHGDH RPL29 RPL7 PMC7491384__F3 Dietary Regulation of Immunity NLRP3 EIF2A PMC10141597__F1 Profiling Germinal Center-like B Cell Responses to Conjugate Vaccines Using Synthetic Immune Organoids CD40 BCR MBP PMC7965690__F4 How MARylation is predicted to be involved in the regulation of colorectal cancer MACROD2 APC GSK3B AHR CTNNB1 PMC2874225__F1 The DSBR and SDSA meiotic recombination models RAD51 SPO11 DMC1 PMC5715672__F3 Pathway of catecholamine biosynthesis TH PNMT DBH PMC7436979__F6 Components-Targets-pathway network MAPK1 NOS2 EGF JUN EGFR PTGS2 MMP9 VEGFA IL6 CCL5 TNF MAPK3 IFNG HMOX1 TLR4 EDN1 RELA CASP3 BCL2 IL1B PMC5500762__F3 Lysine acetylation events involved in carbon fixation (A), tricarboxylic acid cycle (B), and photosynthetic pathway (C) HEL107 SDHA SDHB CYB RPIA MNT FES CS ASPA PMC3465263__F10 Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt1−/− Mice PCMT1 PTEN PMC3479191__F5 Multilevel factors cooperatively perturb pathways MAPK1 PPP2R2C SMAD1 COMP DKFZp781O1323 RASSF1 E2F2 BMPR1A MYC E2F5 ARAF GDF5 HRAS RB1 CDKN2A INHBB SMURF1 INHBA INHBE CDKN1A ID4 EP300 SMURF2 CCND1 PMC11281550__F6 Changes in metabolites in PI3K/AKT/FOXO signaling pathway after TeA, PAT alone, and combined exposure STAT3 KLF2 EGFR SMAD4 BNIP3 PTEN INS SKP2 SET ATG12 INSR CDK2 ATM NLK MDM2 SIRT1 PMC5996928__F5 Molecular signaling pathways involved in astrocyte reaction in AD TF STAT3 HEL-S-62p IL18 PMC3466807__F1 BOLERO-2 trial: the addition of everolimus to exemestane in the treatment of postmenopausal hormone receptor-positive advanced breast cancer RHEB TSC2 TSC1 PTEN MTOR PMC3604893__F1 A) Model of multi-agent vs ALOX5 BCR MUC1 PMC4713514__F5 Focal adhesion pathway analysis based on the KEGG database CRK BAD VASP FYN HEL-S-28 PTEN ARHA SHE PMC9630602__F2 Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases GSDMD NLRP3 FOXO1 IRF3 PTEN DFNA5 MDM2 TRAF6 MYD88 PMC9630602__F4 Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases TBK1 IRF3 TRAF6 PMC12185430__F2 Gut microbiota-derived metabolites in MASLD pathogenesis under dysbiosis FGF8A CYP2E1 TLR4 CD14 AHR MTOR LBP PMC12185430__F3 Botanical drugs-mediated immunomodulation through LPS/TLR4 signaling TLR4 TNF MYD88 PMC5635727__F3 In HF, SERCA2a is a vital target regulated by Lut for effective cardiomyocyte contraction and relaxation PLN SUMO1 PMC12185430__F1 Mechanistic framework of the “multiple-hit” hypothesis in MASLD progression The pathogenesis of MASLD involves sequential pathological hits driving progression from hepatic steatosis to end-stage liver injury TG TLR4 IL6 TNF PMC12205216__F2 Natural products downregulating TGF‐B pathway in treatment of leukemia SMAD2 SMAD4 CDK9 CCND1 CDK4 PMC7397827__F1 Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL) TLR3 MLKL RIPK1 TNF PMC6945981__F5 Effects of perlecan deficiency on transcriptome changes in (A) the 1-day study groups and (B) the 7-day study groups VWF MAK CHAD PMC6030166__F6 Combined network analysis of metabolites and lipids ACLY PIK3CA GAD1 SGMS2 GFPT1 PSMA4 ACD MYC ABAT HMOX1 NAGS AARS2 TTL IMPA2 HEL-S-80p FAHD1 AIMP2 FARSB UBB ATAD2 UBC CIC GOT2 CES2 FOLH1 GCLM APOE PTGS2 BCL2L11 SDHA PAICS SLC25A12 TK1 HEL-S-69p GCLC HLA-B ASNS HLA-C PYCR2 MAT1A PMC4770165__F1 Aryl hydrocarbon receptor signaling pathway is depicted with 3,3′-diindolylmethane as a model agonist CYP1A2 AHR AHRR CYP1B1 CYP1A1 PMC6030166__F8 Central carbon metabolism in cancer ACLY IDE GLS HEL-S-133P ELL PFKFB2 PTEN TIGAR MYC SLC16A3 SIRT3 OGDH ERBB2 HEL-S-32 GCK SIRT6 PMC7397827__F5 Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL) ZBP1 TLR3 MLKL TNF PMC12205216__F3 Natural products upregulating TGF‐B pathway in treatment of leukemia SMAD2 SMAD4 PMC12205216__F4 Natural products targeting TGF‐B pathway in treatment of colorectal cancer SMAD2 SMAD4 PMC8269285__F10 Monosomy 3 Is Linked to Resistance to MEK Inhibitors in Uveal Melanoma ATF3 REST F2 MAL VEGFA PMC5384023__F7 tmTNF-Alpha-induced STAT1-dependent apoptotic signaling via TNFR1 STAT1 TRADD TRAF2 FADD PMC11662063__F6 Proposed model suggests that SS18-SSX drives the acitivation ofTYK2/STAT3/Bcl2 axisthereby mediating apoptosis evasion in SS cells STAT3 BCL2 TYK2 PMC5414786__F7 Components of insulin signaling pathway and the up-regulated genes with H3K27ac- or H3K4me3-increased regions by decidualization FAS CBL INSR FOXO1 GRB2 MTOR SHE PMC3261278__F1 Synaptic translation and signaling pathways modulated by FMRP (a) and dysregulation of these pathways in the absence or significant reduction of FMRP (b) DLG2 APP ARC MMP9 EIF4E PMC3261278__F2 Targeted treatments for fragile X syndrome CYFIP1 PTEN ARC MTOR PMC7034838__F3 Iron metabolic pathways in the processes of sponge plasticity CPOX NGB FECH UROD UROS PMC11728517__F4 Extrinsic and intrinsic apoptosis pathway BAX TRADD TRAF2 FADD PMC8229991__F2 Activin-A Induces Early Differential Gene Expression Exclusively in Periodontal Ligament Fibroblasts from Fibrodysplasia Ossificans Progressiva Patients BMPR2 SMAD9 ACVR2B SMAD1 ACVR2A FSTL3 DKFZp781O1323 SMAD2 SMAD4 INHBB INHBA ACVR1 FST ACVR1C PMC11954783__F2 Review of recent molecular pathology of bladder urothelial carcinoma RNF43 APC LRP5 ZNRF3 LRP6 GPR49 CTNNB1 LGR6 PMC7509150__F5 KEGG analysis for signaling pathways CD40 TH LTA TRADD TIRAP LAT CXCL1 TRAF3 TRAF6 LPA BCR NOD2 SI MMP3 ATM JUN SELE LIF CD14 BLNK TNF FOS LTB NPB LYN LBP TRAF2 FADD PMC6414514__F4 Dynamic mechanism of ADP-ribosylation reversal PARG MACROD1 NUDT16 NUDT5 MTOR PMC7556678__F1 Thromboinflammatory pathways in sickle cell disease TF VWF TLR4 PMC9559307__F1 Biomarkers in the Management of Colorectal Liver Metastases BAX EGF BAD IGF1 APC GSK3B PTEN IGF1R CTNNB1 PMC3156642__F1 Crosstalk between the canonical and non-canonical transforming growth factor-beta1 (TGFB1) and myostatin pathways SMAD2 SMAD4 PMC12139502__F2 Proteome features of the four major heart cell-types GATA2 ASS1 ASL HSPG2 ITGB4 MYH6 CTNND1 OTC VTN ATP2A2 CTNNB1 CTNNA2 JAM2 ACTA2 MYH7 MYL12B MYH13 CLDN5 RYR2 NOS2 MCAM DAG1 TNNC1 MYH1 ARG1 ARHA ERG PECAM1 XB CCR4 GJA1 PMC6102278__F8 Fas-mediated EGF-induced EGFR signaling A proposed model of the robust EGF-induced EGFR signaling pathway mediated by the pro-survival, phosphorylated Fas that can lead to aggressive behavior of cancer cells is presented here STAT3 EGF FAS YES1 EGFR SRC CCND1 PMC1876696__F1 Pathways for the synthesis of the major phospholipids in S TG IPP PSD PEMT PC PMC10928192__F1 TNF/TNFR1 signalling through complex I TRADD RIPK1 TNF TRAF2 PMC10928192__F2 TNF/TNFR1 signalling through complex II RIPK3 TRADD MLKL RIPK1 TNF TRAF2 FADD PMC10928192__F3 Interplay between TNF/TNFR1 complex I and complex II signalling pathways RIPK3 TRADD MLKL TAB3 RIPK1 TNF CYLD TRAF2 FADD PMC5058780__F2 FAK and paxillin, two potential targets in pancreatic cancer RHO GRB2 SRC PMC6902872__F1 Pathway to chronic rapamycin therapy in prostate cancerModel: Chronic mTORC1 inhibition delays of PCa progression from active surveillance EEF2 MTOR EIF4E PMC11744640__F6 Molecular mechanisms of SARS‐CoV‐2‐induced pulmonary fibrosis TMPRSS2 IFNG TREM2 ACE2 PMC11744640__F8 Canonical and noncanonical TGF‐B signaling pathways TGFBR2 TRAF4 SMAD2 SMAD4 ARHA MTOR TGFBR1 PMC11744640__F9 Important signaling pathways involved in fibrosis TGFBR2 CGAS NR1C1 HEL-S-28 SMO ATF4 IL11RA XBP1 CTNNB1 TGFBR1 PMC308804__F4 Visualizing protein interaction networks in HPRD MAPK14 OPRK1 CRK SYK SOS1 CRKL KDR GRB2 SRC CEBPB DRD3 LCK PMC5173100__F8 Novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway CDK6 CDK2 CCNA2 CDK4 PMC7828713__F2 Microglial regulation of neuronal networks and CNS homeostasis CX3CR1 BDNF PMC3896667__F5 Significantly altered pathway in primary tumor MMP7 ATR MYC DOCK1 RB1 CRK CBL PRKDC PDGFRA AXIN1 LAMB2 EP300 MDM2 PMC4013180__F3 Multiple pathways can stimulate Beta-cell replication in obesity, and there is overlap of many of the downstream activators HGF PDX1 EGFR GSK3B CAMK4 PMC4444223__F1 Model diagram of tumor necrosis factor-alpha (TNFA) signaling TNF FADD PMC9097379__F7 ROCK-ezrin signaling pathway mediates LPS-induced cytokine production in pulmonary alveolar epithelial cells SYK HMGB1 IRAK1 ARHA IL1B MYD88 PMC8362831__F1 Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1+/−/Tis21KO Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the PI3K Inhibitor MEN1611 PDGFD SMG1 TIMP1 EIF3A PTEN MTOR DEPTOR PTCH1 SIK2 IL8RB SRC CXCR4 RRAGA PMC7828713__F1 Effectors of microglia function associated with neurodegeneration and how microglia damage or kills neurons TREM2 HTT C9orf72 PMC6315857__F1 Transforming growth factorB 1 (TGFB1) mediates a signaling pathway in tissue fibrosis ATR SMAD2 SMAD4 ATM ARHA MTOR TRAF6 TGFBR1 PMC5696728__F2 Oncolytic virus mediated enhanced anti-tumoral immunity, including enhanced CAR T-cell recruitment and effector function CD40 CXCL9 IFNG ICOS FAS CGAS BATF3 CCL4 CXCL10 PMC5662566__F3 Integrin-linked kinase (ILK) signaling pathway is altered following RVFV infection KRT18 HEL114 HEL113 PXN RSU1 BMP2 NCK2 NACA LEF1 PMC9483736__F8 Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress STAT3 TNC MTOR CXCL8 TGFBR1 TGFBR2 PLCE1 PLCG1 CXCR1 ERBB2 IL8RB ACVRL1 BIRC3 PMC5765116__F9 DENV2-induced autophagy is ER stress-UPR dependent, involving PERK-eIF2Alpha-ATF4 and IRE1Alpha-JNK-BECN1 pathways ATG12 ATF4 EIF2A PMC3774329__F6 The interactions between Rho/Rho-kinase signaling and bone morphogenetic protein (BMP)/transforming growth factor (TGF)B signaling PPIC GIP RHO PMC5025790__F9 Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency SMAD1 DKFZp781O1323 SMAD2 CRIPTO SMAD4 NODAL PECAM1 CTNNB1 PMC7890422__F1 Caveolin-1, a master regulator of cellular senescence HMGB1 SP1 IGF1 EGFR RHO MDM2 SIRT1 PMC9270398__F9 Working model of TRIM24 in regulation of P-bodies in response to insulin AGO2 TRIM24 EDC4 IRS1 PMC4297187__F2 Schematic summary of the results obtained from the microarray analysis DIXDC1 SOX17 PRICKLE2 TAX1BP3 TLE4 FZD7 LRP5 LRP6 DVL2 DAAM2 AXIN2 SFRP1 DKK3 SFRP4 CTBP2 VANGL1 DKK1 FOSL1 FZD1 WIF1 PMC9174896__F2 Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years DUSP5 ACTR2 BMP4 APC PMC2757940__F2 Major components of FGF and HH signaling pathways FRS2 SUFU SMO GRB2 PMC5797063__F1 MicroRNA expression and activity in T-cell acute lymphoblastic leukemia FBXW7 NRARP NOTCH1 PMC7448411__F1 Wnt/Beta-catenin signaling by miRNAs CDH2 STAT3 FRAT1 APC GSK3B LRP5 LRP6 SFRP1 YWHAZ PMC7448411__F2 Use of miRNAs to combat EMT ASCL2 PMC3541304__F1 Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis TSC2 TSC1 CDKN1A DDIT4 HIF1A MTOR DEPTOR PMC3106338__F10 INTERFERON-ALPHA MEDIATES THE DEVELOPMENT OF AUTOIMMUNITY BOTH BY DIRECT TISSUE TOXICITY AND THROUGH IMMUNE-CELL RECRUITMENT MECHANISMS TG TSHR APC CXCL10 OAS1 TRIM21 PMC6851267__F8 Ghrelin attenuates neuroinflammation and demyelination in EAE involving the NLRP3 inflammasome signaling pathway and pyroptosis GSDMD NLRP3 IL1B PMC10952045__F4 Various molecular mechanism of the osteogenic and osteoclastogenic function through cellular uptake of GNPs and functionalized GNPs NPS OSM EBP BMP2 OSCAR NFATC1 RUNX2 RAC1 PMC9636824__F9 Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation of Rb family proteins RB1 CDK6 CDK2 MTOR CCND1 CDK4 PMC7484401__F4 ANM analysis on long-term PIMi treated cells finds changes in protein complex enriched for signaling and growth pathways CD40 FLT3 MYB PIK3CD CYCS GSK3B MYC PIDD1 CDK6 IFNGR1 VEGFA PCK2 IGF1 CDKN1A SOS2 IFNAR1 TRAF1 VCAM1 TNFAIP3 CTSH DDIT4 RELB IGF1R MTOR TNFRSF10A PRKCB CCND2 YWHAQ F2R GADD45B ATM BIRC3 HSP90AB1 BAX ACTG1 IFNA17 THBS1 JUN RRAGD EIF4EBP1 BCL2L11 PTPN6 FGF7 IL2RB HEL-S-125m ITGA1 NFKB1 CASP3 STAT4 LYN TNFSF10 PMC2572865__F1 Hematopoietic niche and bone meet BMPR1A DKK1 LRP5 PTH PTH1R CTNNB1 PMC5726441__F4 PI3K pathway in human disease RHEB TSC2 TSC1 PMC5726441__F1 PI3K pathway in human disease RHEB TEC TSC2 BTK TSC1 CSH2 C2 INPP4B PI3 ITK PTEN RHO PMC5726441__F6 PI3K pathway in human disease BAD PIM1 SGK1 PTEN SRC MYC IRS1 PMC3164321__F1 KEAP1 Cullin-3 E3-ubiquitin ligase complex and its roles in maintaining cellular levels of NRF2 and IKBKB RBX1 KEAP1 IKBKB PMC8235118__F8 Mitochondrial Function Are Disturbed in the Presence of the Anticancer Drug, 3-Bromopyruvate MAX HEL-S-162eP HEL-S-44 PMC6622839__F9 Model of VAMP3- and VAMP7-dependent surface transport SNAP23 VAMP3 VAMP7 PMC9255244__F3 Fusobacterium nucleatum: a new player in regulation of cancer development and therapeutic response CFD TLR4 NFATC3 MYD88 BIRC3 PMC7816800__F4 Functional interactions between genes under positive selection in the insulin signaling pathway (ingenuity pathway analysis, IPA) ACLY CRK BAD CBL GRB10 VAMP2 LIPE PTEN SOCS3 GRB2 PMC7816800__F5 Functional interactions between genes under positive selection in the SIRT signaling pathway (ingenuity pathway analysis, IPA) RARA WRN RELA PMC7816800__F6 Functional interactions between genes under positive selection in the NF-ĸB signaling pathway (ingenuity pathway analysis, IPA) CD40 EGF NGF LTA TRADD TIRAP RELB HDAC2 PMC7816800__F7 Functional interactions between genes under positive selection in the mTOR signaling pathway (ingenuity pathway analysis, IPA) RHEB TSC2 EIF4B INSR PC RHO MTOR ELF3 IRS1 EIF4E PMC7369834__F1 Genomic and non-genomic effects of glucocorticoid receptor (GR) binding to the different players of the inflammatory and metabolic pathways involved in the Duchenne muscular dystrophy (DMD) myocyte DMD MTOR IRS1 PMC8020906__F2 mTOR is activated by growth factors via PI3K-Akt and RAS/MAPK pathways RHEB PTEN PMC11853774__F1 Crosstalk between the Hedgehog (Hh) and PI3K pathways in hematological malignancies FLT3 SUFU GSK3B FOXC1 SMO MTOR PMC5290741__F5 Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine RHEB TSC2 TLR1 TSC1 AKT3 PTEN MTOR MYD88 PMC8827382__F2 p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets ATG10 ATG3 ATG12 ULK1 UVRAG AMBRA1 ATG14 ATG5 ULK2 PMC8827382__F1 p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets BAX BCL2 MDM2 MTOR TNF FADD PMC4472234__F4 Elementary Flux Mode Analysis Revealed Cyclization Pathway as a Powerful Way for NADPH Regeneration of Central Carbon Metabolism RPE PGC PTS KIT CS PMC7335672__F9 miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells LTB PTGDR LTA COX1 PTGIS LTC4S KPG_011 PTGIR PMC8020906__F5 Interplay between HBP, mTOR, and AMPK signaling pathways RHEB OGT TSC2 TSC1 GYS2 GYS1 ULK1 PTEN PMC8020906__F3 mTOR in cancer stem cells (CSCs) SOX2 CTNNB1 PMC8020906__F4 AMPK pathway activation and energy homeostasis CAMKK2 HMGCR TXNIP GYS1 ULK1 PMC8469128__F1 MicroRNAs—The Heart of Post-Myocardial Infarction Remodeling ENG SP1 FURIN PMC7929927__F8 BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection TMED9 C20orf185 PMC8469128__F2 MicroRNAs—The Heart of Post-Myocardial Infarction Remodeling COL1A1 PTEN MTOR EGR2 TRAF6 SPRY1 PMC5404743__F1 New Milestones Ahead in Complement-Targeted Therapy COMP FH HEL-S-62p CR2 CS PMC7401802__F1 Biosynthesis of CL and PE LPA PGS1 PGP HMFN0839 MOG PRELID1 AGPAT4 PLSCR3 PC PTPMT1 FLJ10842 PISD PMC4933442__F8 TNF-Alpha-induced expression of the inflammation-associated genes mediated by PLCE LPA CXCL1 CCL2 CXCL8 PMC1905845__F1 Schematic representation showing the plausible signaling events from uPAR integrin complex BAD FAS PLG PTEN MTOR FADD PMC2662295__F5 TRAF6- and MEKK1-mediated signal for IFNB production in the RLH/IPS-1 signaling pathway IRF3 TRAF3 TRAF6 FADD PMC8160027__F2 Vital role for nitric oxide in intraocular pressure homeostasis NOSIP PLCG1 NOSTRIN PMC8160027__F3 Vital role for nitric oxide in intraocular pressure homeostasis PIEZO1 SRC PECAM1 CTNNB1 PMC2905744__F3 Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors BAD PTEN MTOR PMC3826168__F2 Molecular mechanism and function of CD40/CD40L engagement in the immune system CD40 TRAF3 TRAF2 PMC3013016__F8 The molecular mechanisms employed by the Ras/MAPK pathway to regulate mTORC1 signaling RHEB TSC2 TSC1 EIF4E PMC8534692__F7 Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Protein Knockout Mice NPC1 HK3 MSMO1 FABP1 SC5D ACSS3 MOGAT2 ACOT12 ACSS1 PGAM1 HEL-S-5 SOAT1 FDFT1 PMC6411465__F9 A schematic diagram illustrating the proposed mechanism of AR‐CD44‐SOX2 signaling CD44 SOX2 PMC7759768__F3 Major sources of oxidative stress in Parkinson’s disease and the corresponding antioxidant defense mechanism in dopaminergic neurons TH BAX CASP9 BAD GFAP CASP3 DKFZp666G145 HEL-S-11 PMC9139943__F3 Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance ATR MRE11A FEN1 SSB PMC8842882__F1 Signaling networks orchestrate metabolism for coordination of T cell fate BATF IRF4 MYC PMC11049012__F1 BCG-driven activation of the bladder cancer TME involves the NFKB/TNFA signaling pathway and IRFs/IFN pathway CXCL9 CXCL11 CXCL12 CCL22 COX2 CCL5 CXCL10 TNF CXCL8 PMC9139943__F4 Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance RAD51 E2F4 BRCA1 PMC9139943__F6 Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance PARG SLFN11 PALB2 SSB PMC7956519__F2 Main non-canonical signaling pathways activated by JAK2V617F in Ph-negative MPNs TIRAP EPOR BCAM ATF2 TRAF6 MYD88 PMC7956519__F3 Major non-canonical mechanisms derived from CALRMut HEL-S-72p TAPBP FLI1 RPL11 OXR1 APC HEL-S-269 MSI2 HEL-S-89n TAP2 PMC4178743__F7 Interference in type I IFN production by HEV proteins MAVS TRIM25 IRF3 PMC11737358__F2 Metabolic pathway of homoarginine (hArg) synthesis and associated substrates SLCO4C1 ASS1 ASL OTC ARG1 PMC99537__F5 Basic metabolic pathways in C PTS FES GHR PMC3244200__F4 Epithelial–mesenchymal transition (EMT)-related pathways EGF JUN EGFR SHH FOS PMC6099423__F1 Model about the effect of indoleamine 2,3-dioxygenase 1 (IDO1) on the utilization of the main energy sources by activated CD4+ T-cells IDO1 APC AHR CPT1C CPT1A PMC6028720__F3 Compound–target–pathway subnetwork of 12 compounds relating to AD CYP2A6 TNKS2 ABCC1 MCL1 GSK3B TLR9 SIRT2 DHODH DAO MAOA MAPK14 DRD1 DRD2 CHRNB2 PTGS1 ADORA2B PSIP1 BCHE ABCB1 GGPS1 CES1 HSD17B10 MVK HPGD AURKB CYP2C9 CDK2 BCL2 MAPK10 HTR7 EGFR BACE1 NOX4 SIRT3 CA12 SLC18A2 F3 ALOX15 ELANE ABCG2 TNK2 KIF11 HSD17B3 CHRNA7 PTPN1 PTGS2 SLC6A2 PARP1 GMNN VKORC1 HCAR3 ATAD5 TRPA1 POLK TNKS HSD17B1 CHEK1 NFE2L2 PTGES PRSS1 CYP3A4 PMC7118423__F2 The angiotensin-converting enzyme 2 (ACE2) signalling pathway involved in SARS-CoV-induced CCL2 expression CCL2 ACE2 PMC7864727__F1 Epigenetic Regulation and Nonepigenetic Mechanisms of Ferroptosis Drive Emerging Nanotherapeutics in Tumor STEAP3 DPP4 HEL-S-102 FACL4 FES PMC3666381__F1 Metabolism in totipotent stem cells CAD HEL-S-133P PC PMC3666381__F2 Metabolism in pluripotent stem cells GLDC HEL-S-49 HEL-S-162eP PMC5852605__F1 Canonical and non-canonical Wnt pathways and their effects in pluripotent stem cells (PSCs) APC ATF2 RHO PMC11889860__F5 Apium graveolens-associated Aspergillus sp.: metabolomic profiling and anti-MRSA potential supported by in silico studies CD40 CSA2 TIRAP IRF9 CTSK TLR9 CD14 TRAF6 IRAK4 RAC1 MYD88 TYK2 LBP FADD PMC11889860__F6 Apium graveolens-associated Aspergillus sp.: metabolomic profiling and anti-MRSA potential supported by in silico studies IL15 JUN CD2 TRADD SELE MLKL LIF CD5 IL6 TNF CXCL10 FOS C2 EDN1 NOD2 CASP3 MMP3 CYLD FADD PMC3965173__F1 Signaling pathways that can be inhibited to increase the radiation response of tumors BAD EGFR PTEN MTOR PMC8941656__F1 Evaluation of Iron Deficiency and Iron Overload BMP6 TFR2 EPO HFE IL6 HFE2 PMC5287922__F2 Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases IL23R IL12RB1 PMC1237009__F1 Will the Real Cholesterol Transporter Please Stand Up TG ABCG8 ABCG5 ACAT2 ARF1 NPC1L1 ABCA1 PMC11049059__F8 CCN1-mediated signaling pathway in pregnant women with SARS-CoV-2-infection ENG PIGF CYR61 TGFBR1 PMC7483921__F7 Inhibition of Wnt/Beta-catenin signaling by TcdA WNT3A APC GSK3B CCND1 CPD RAC1 CTNNB1 PMC8145791__F14 TRPC channel-derived calcium fluxes differentially regulate ATP and flow–induced activation of eNOS ORAI1 TRPC4 TRPC3 PMC5086093__F7 Models depicting consequences of PNH-related mutations on NEDD4L stability and PI3K/Akt/mTOR and TGFB/Smad pathways RHEB DAB1 TSC2 TSC1 C2 SMAD2 PMC2829061__F7 Cdk1 Targets Srs2 to Complete Synthesis-Dependent Strand Annealing and to Promote Recombinational Repair CDC2 RAD51 SIX5 PMC7452853__F11 Proposed mechanisms associated with 10% XCDM-induced hTM cell stiffening and Wnt pathway activation-mediated rescue of cells from stiffening CD44 ACTA2 CAVIN1 LRP5 LRP6 ARHA AXIN2 TNLG7C CTNNB1 PMC8504146__F5 Non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential ENG HEL-S-11 PMC12254798__F1 Obese adipose tissue (AT) microenvironment interacts with tumor cells during cancer progression STAT3 IL10 NLRP3 FABP4 PMC8504146__F2 Non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential CDH2 AXL EGFR PMC11356869__F1 Signaling pathways in osteogenesis and osteoclastogenesis SMAD1 DKFZp781O1323 BMP2 CTSK SMAD4 NFATC1 TRAF6 RUNX2 CTNNB1 PMC11356869__F2 East Asian Herbal Medicine (EAHM) effect on bone to prevent osteoporosis COX2 BMP2 IRAK1 MMP3 TRAF6 RUNX2 CTNNB1 MYD88 PMC8536789__AF1 Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease LAMP2 DGAT1 ATF4 PMC7886759__F3 Lipotoxic UPR induces hepatic cell death ATF3 BCL2 EIF2A TRAF2 PMC10141502__F1 Nutrigenomic profiling of reduced specification diets and phytogenic inclusion effects on critical toll-like receptor signaling, mitogen-activated protein kinase-apoptosis, and PI3K-Akt-mTOR gene components along the broiler gut HRAS TSC2 LTA FAS LITAF TLR3 TLR4 CHUK IRF3 IL6 TRAF6 MYD88 PMC7886759__F4 Modes of cell death in NASH FAS GSDMD NLRP3 MLKL PMC6102695__F7 Kyoto Encyclopedia of Genes and Genomes pathway map illustrating ‘hsa05200: Pathways in cancer’, as identified by pathway enrichment analysis using the Database for Annotation, Visualization and Integrated Discovery BAD HAL KMO PMC6500972__F8 Poly(ADP‐ribosyl)ation of BRD7 by PARP1 confers resistance to DNA‐damaging chemotherapeutic agents RNF146 BRD7 PARP1 PMC3210466__F1 MTOR signaling pathways RHEB TSC2 RICTOR TSC1 PTEN MTOR DISC1 EIF4E PMC4991447__F9 Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1A via the PI3K/AKT/mTOR pathway CDH2 MTOR PMC7986493__F10 Glycine, serine, and threonine metabolism pathways of L AGXT PHGDH PSAT1 PSPH PMC3370224__F9 The ARF6 signaling pathway involved in HLHCGR internalization as deduced from the present study ARF6 LHCGR PMC5357501__F4 The significance of SIRT1 in Alzheimer’s disease RARB BACE1 APP ADAM10 SIRT1 PMC5038066__F7 Proposed model for Leishmania donovani-mediated host TLR2 downstream signaling TLR1 COX2 NFATC2 PMC4484471__F8 Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2 MACC1 HGF GC TWIST1 PMC7809420__F5 Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration RGS2 HPSE EHHADH HEL113 MMP14 VASP GEM LNX2 LRAT PROCR CDIPT FGFR2 NGF CDA CYBA EMILIN1 BAX EFNB2 GPC1 JUN CERK MAL HAMP GLA RERG TINAG TUBB HAND2 SET ASPG PTPRS SOWAHB CMIP RHOB MYL12A MMP27 SMYD4 MGAM EDEM2 ADAM10 LRCH1 PDCL LBP FNDC10 PMC6305110__F1 Promising immune checkpoint LAG-3: from tumor microenvironment to cancer immunotherapy HEL-S-92n CD80 HHLA2 LAG3 PMC8169545__F2 Novel ligands and modulators of triggering receptor expressed on myeloid cells receptor family: 2015–2020 updates LPL SYK ADAM17 APOE ADAM10 PMC5489658__F8 Schematic summary of the mechanisms by which tick-borne Phlebovirus NSs proteins inhibit the canonical IFN induction and signaling pathways TBK1 STAT1 IFNGR2 IFNGR1 IFNLR1 MAVS STAT2 IFNAR1 IRF3 JAK1 TYK2 PMC4399027__F2 Activation of the MAPK pathway in thyroid cancer TPR ETV6 NTRK1 BRAF NTRK3 FLJ10842 RET AKAP9 PMC6302542__F3 Leptin regulates fatty acid oxidation in muscle by activating AMPK POMC MC4R NPY AgRP PMC3068086__F5 Coordinately up-regulated cell cycle genes in CD8+ T cells from the VIR group (VIR versus BDL) illustrated in cell cycle pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/) CDK7 PCNA CDK2 PMC3068086__F6 Branches of MAPK pathway significantly enriched in CD4+ T cells from the LTNP group (BDL versus LTNP) CDC42 HRAS JUN NFKBIA CREBBP MAPK9 NFATC3 GRB2 MAP2K3 FOS PMC4012993__F6 Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation JUN APPL1 APC AKT3 GSK3B PAG1 HEL-S-28 NR1C2 TCF4 AXIN2 CTNNB1 DKK3 FRAT1 RARA F2R WNT7A WNT4 FZD1 SRC CCND1 SOX5 WIF1 PMC7037284__F1 Guanylyl cyclase-cGMP signaling pathway PGC NPS CNP PMC6028303__F2 Revisiting antipsychotic drug actions through gene networks associated with schizophrenia MDK NCAN PTN DRD2 AKT3 MED19 SREBF2 RRAS EP300 TCF4 FURIN MEF2C PMC9130392__F1 mTOR pathway gene expression in association with race and clinicopathological characteristics in Black and White breast cancer patients RHEB TSC2 TSC1 PMC9406168__F6 Integrative, In Silico and Comparative Analysis of Breast Cancer Secretome Highlights Invasive-Ductal-Carcinoma-Grade Progression Biomarkers MAX LTBP1 STAT3 LAMA5 SMAD1 TGFBI DKFZp781O1323 HSPG2 EGFR SDC4 SMAD4 MTOR LAMC1 MYC LAMB1 CTNNB1 PCSK9 AGRN LDLR CCND1 ACTG1 FBN1 THBS1 GPC1 DAG1 SP1 LAMC2 LGALS3BP CTSL FZD7 VEGFA ASCL2 FOS LOXL2 ITGB1 ME2 LAMB3 LAMB2 PMC3068086__F7 Schematic overview of the network of enriched pathways related to HIV disease progression BAX BAD CASP3 PMC5315647__F7 Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis XPA ATR MC1R POMC PMC3068086__F4 Coordinately up-regulated TCA cycle genes in CD8+ T cells from the VIR group (VIR versus LTNP) illustrated in TCA cycle pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/) ACLY PCK2 MAPDA OGDH SUCLG2 HEL-S-32 MDH2 SDHC PMC8251939__SF4 Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors DCC BOC PMC5315647__F9 Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis XPA ATR ASIP PMC5587765__F3 IPA canonical pathway analysis and molecular activity of genes regulated by p53 in response to OT in differentiated SH-SY5Y cells HTRA2 BAX CASP9 BAD FAS CASP8 CYCS TNF ID1 ROCK1 DFFA CASP3 DDIT3 MAP3K5 GADD45A GAS1 PRODH BIRC2 APAF1 DIABLO PMC7720404__F1 TF-miRNA-gene network STAT3 PPARG PLCB4 CLDN22 DKFZp781O1323 PIK3R5 GNG5 SOS1 USP45 PIK3R3 SEMA4G WASL PPP3R1 AKT3 CLDN10 PAK4 CLDN3 CLDN16 DUSP2 PRKCB STAT5B NKX2-2 CX3CL1 PRKCA NKX2-5 KPNA1 CALML3 ESAM ROCK2 GNG10 E2F2 MYH10 RBL2 ITGB3 SEMA4D CCNE2 RUNX1 GNA11 CALM1 PLCB2 DGKE GRB2 PS1TP5BP1 PMC1781924__F1 Thy-1-associated signaling pathways STAT3 SMAD1 FYN THY1 LAT PI3 ARHA PMC8505958__F2 Abnormal Airway Mucus Secretion Induced by Virus Infection STAT3 TGFA SP1 IDO1 EGFR TRPV1 AHR IL1B PMC10606123__F1 Underlying mechanism of histone deacetylases in regulating ovarian cancer metastasis HDAC3 KLF4 FOXA1 SIRT3 HMGB1 HDAC5 HDAC9 SIRT1 CTNNB1 HDAC6 PMC4693276__F4 The synthetic lethality pathway model based on a deficiency in Alt-NHEJ and the double-strand break repair pathway BRCA1 BRCA2 POLE PMC3943304__F5 Activation of growth factor receptor protein tyrosine kinases results in autophosphorylation on tyrosine residues BAD PTEN MDM2 PMC7288517__F6 Mechanisms of accelerated aging triggering PD RBMS1 ADD2 B3GNT2 FOXP3 BCL6 PMC3943304__F6 Canonical and non-canonical JAK-STAT pathway and its subversion by BCR-ABL or mutant KIT KIT MTOR SRC CCND1 GAB2 PMC7288517__F5 Shortest paths for enrichment analysis of KEGG and BP ACSL6 FABP1 B3GNT2 FOXP3 BCL6 ATL1 IL12RB1 PMC9659971__F2 Immunometabolism in the tumor microenvironment and its related research progress SLC16A3 GPR132 MYC TNF PMC9659971__F3 Immunometabolism in the tumor microenvironment and its related research progress RIPK3 CD36 FASN SIRT4 PCK1 PMC4630370__F8 Proposed mechanism for NFKB signaling inhibition mediated by the antitumor peptide CIGB-552 BTRC MAP2K6 ITCH MAP3K7 SKP1 ETHE1 TRAF6 COMMD1 SETD7 PMC4931624__F1 The Wnt signaling pathway and possible points for therapeutic interventions to restrict S100A4-mediated tumor progression and metastasis S100A4 DKK1 APC GSK3B LRP5 LRP6 CTNNB1 PMC9708673__F1 Pathway-level mutation analysis in primary high-grade serous ovarian cancer and matched brain metastases STAT3 TJP1 C3AR1 SMC3 JAK3 FGF7B PIK3R1 KALRN PLCL1 OR2T12 OR52N4 GOLGA3 GRIK2 RAB6C NISCH CACNA1F TEC SMPD4 SUPT6H PIK3C2B RGPD4 CLVS1 APOBEC3F NCOR1 PLCG2 COL22A1 CD93 CLTA SHH HEL-S-26 PDE4A P2RX7 TRIO FZD2 PDE10A MEGF10 USO1 APC PLG DNAJC6 SMC1A PTK2B RICTOR POLA1 PDE1A SPTAN1 WNT10B TET2 BRD4 BRCA2 IGF1R MTOR RUNX2 XBP1 pp6425 MDM4 SLIT2 TLR4 MYH9 PDE3A ATM APP PLCB3 CLTC DNMT3B RPTOR VWF ITGA4 KMO DSG1 PDE5A ANXA1 EP300 PMC5356908__F2 Immune cells in liver regeneration STAT3 HEL-S-62p MYD88 PMC4969639__F7 Proposed model for IFNGamma-induced apoptosis of HNSCC cells IFNG CASP9 CASP4 CASP3 ATF2 JAK1 PMC7139641__F3 Network of the most strongly dysregulated proteins of the glomerular ECM in FSGS HEL-S-78p HBB PMC8833116__F10 Overexpression of chaperonin containing TCP1 subunit 7 has diagnostic and prognostic value for hepatocellular carcinoma CCT7 AFP PMC5160413__F1 RA pathway is differentially regulated in stem cells from VS and SC fat depots HEL-S-101 TNC HEL-S-53e CTSK CDKN2B PITX2 NR2F1 WT1 ALDH1A3 MME PLAT RARB RARRES1 MGP F3 CDH6 PTGS1 HOXA4 MEIS1 RDH10 ALDH1A2 ENPP2 DHRS3 PMC6022997__F3 Illustration showing presumed mechanisms mediating suberoylanilide hydroxamic acid (SAHA)-induced autophagy BAX BAD ULK1 BCL2 TIGAR MTOR PMC6954088__F8 The proposed mechanism for AAV9-shMyh9 against I/R-induced neuronal injury BAX ROCK1 PMC3786590__F1 Simple molecular pathway for sex determination in the mammalian gonads SF1 SOX9 SRY FST FGF9 DHH AMH RSPO1 PMC6172149__F1 Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity TF CXCL9 CXCL11 MAVS TFPI CX3CL1 IL6 CXCL10 TNF PMC3684179__F1 Cyclin D1 stability is regulated by ubiquitination-dependent proteasomal degradation FBXW8 USP2 CCND1 PMC6022997__F1 Autophagy, apoptosis, and cell cycle arrest mediated by the activity of nuclear p53 protein (p53) in its function as a transcription factor in stress conditions BAX TSC2 BAD MAP1B ULK1 BCL2 MTOR ATG5 PMC6022997__F2 Autophagy and apoptosis mediated by the cytoplasmic activity of p53 protein under basal conditions BAX BAD ULK1 BCL2 TIGAR MTOR PMC3247643__F6 Overlay of significant canonical pathway and the connectivity in the molecular mechanism of cancer, with the eight genes in IPA canonical pathway and with the genes in Network (I) that differentially altered in PCB exposure SAA1 TNFRSF12A TGFB1 LAMC2 CD36 ATP1B1 CD46 PSMA2 BCL2L11 KRAS E2F5 HEXB ITGB1 IGFBP5 CCND2 MGAT3 PON1 LDLR BCL2 DKFZp686P11128 CP UNK IL23A PMC3618688__F4 Resection of Non-Small Cell Lung Cancers Reverses Tumor-Induced Gene Expression Changes in the Peripheral Immune System TIRAP RELB TLR9 CD14 TLR5 TRAF6 MYD88 TLR1 MAP3K7IP1 NFKB1 TLR4 REL TLR10 PMC6794464__F2 Scheme of differentiation of M cells in PP TNFAIP2 HEL-S-7 RELA RELB SPIB MARCKSL1 TRAF6 CCL20 SOX8 PMC3786590__F3 Neuroendocrine control of pituitary and gonadal function KISS1 GNRHR ARC KISS1R FSHR PMC8117355__F1 Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer NDRG2 FAS NCK1 EZH2 PARP1 VHL BMI1 STAT1 CBL BTG2 CDKN1A E2F4 PRC1 HEL-S-87p CP PMC9055624__F2 Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease EGF PLCB2 SRC ACE2 PMC3745819__F1 A CENTRAL ROLE FOR INDUCIBLE HEAT SHOCK PROTEIN 70 IN AUTOIMMUNE VITILIGO CD40 CD83 CD80 PMC5059430__F9 EtOH-induced BK channel internalization via Wnt/Beta-catenin signaling APC LRP5 LRP6 CTNNB1 PMC7863132__F2 Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease PLN BAX MCU PMC4631624__F1 Homologous recombination deficiency: Exploiting the fundamental vulnerability of ovarian cancer BARD1 FANCD2 RAD51 DNA2 BRCA1 BRCA2 ATM FANCM FAN1 PALB2 BLM SLX4 PMC7863132__F1 Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease PLN MCU PMC7570055__F2 Cigarette smoke-related vascular irritation and activation in patients with COPD LTB CXCL9 CXCR3 TGFA CCR2 CXCL2 CXCL10 HDAC2 IL1B PMC8537160__F1 Wnt and Beta-Catenin Signaling in the Bone Metastasis of Prostate Cancer CDC42 APC ROR2 LRP5 LRP6 ARHA CTNNB1 PMC5385559__F5 Genetic dissection of seed oil and protein content and identification of networks associated with oil content in Brassica napus TH RARA INA PMC12034266__F1 Sphingolipid biosynthesis and metabolic pathways UGCG CERK SGPL1 DEGS1 KDSR PMC8630440__F4 Proteomic analysis of human umbilical cord serum exosomes using mass spectrometry and preliminary study of their biological activities in liver cancer cell lines CD44 VWF CHAD CD47 PMC4120074__F7 Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor ERBB3 NRG1 BRAF ERBB2 PMC8650380__F2 Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications NLRP1 TLR4 MYD88 PMC8650380__F4 Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications TREM2 MBP TLR4 VCAM1 MYD88 PMC4120074__F2 Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor BAX MSH6 NRG1 RICTOR GSK3A HEL-S-162eP EGFR KIT PTEN MTOR LCK PMC6932173__F6 Proposed inositol-requiring protein 1 alpha (IRE1A)-dependent mechanism of type I interferon induction upon proteasome impairment IRF3 IRF7 TRAF3 EIF2A PMC11893557__F2 Impact of autogenous and post-intervention gut microbiota on immune cells in HCC TF IL25 CXCR6 CXCL16 MTOR CXCL10 PMC12196557__F5 Interactive effects of prenatal Poly I:C exposure and antipsychotics on various signaling pathways and receptors in the dorsal raphe nuclei TLR3 AKT3 GAD1 GAD2 CREB1 CTNNB1 PMC12092528__F4 RhoA/ROCK signaling pathway and Tau GSK3B PTEN RHO PMC8760698__F2 Bioactivities and mechanisms of natural medicines in the management of pulmonary arterial hypertension BMPR2 HMOX1 APLN HEL-S-28 PAH MYC NOTCH1 PMC3038181__F1 Activation of the PI3K/Akt pathway in cancer EGFR PTEN TRAF6 DEPTOR PMC3839612__F5 A detailed model of the Rad5-mediate template switch pathway, assuming gap filling dependent on a subset of HR functions after the replication fork has passed RAD18 RAD51 PCNA RMI1 PMC8979958__F3 Mammalian sirtuins and metabolic reprogramming SIRT3 SIRT7 GLS SIRT4 SIRT5 SIRT2 SIRT1 SIRT6 PMC8760698__F5 Bioactivities and mechanisms of natural medicines in the management of pulmonary arterial hypertension HMGB1 NLRP3 BCL2 PAH MTOR EIF2A PMC7779353__F10 Diagram of a signaling regulatory network that determines the AEC II differentiation phenotype ACE2 CTNNB1 PMC3657316__F3 Ciliary signaling pathways implicated in control of cell proliferation ID2 PDGFRA CDK2 PMC3160786__F1 mTOR signaling pathway The scheme depicts mTOR signaling cascade in the regulation of energy and growth factor-dependent translation and autophagy RHEB TSC2 TSC1 ULK1 DEPTOR ELF3 EIF4E PMC3160786__F2 Amino acids sensing of mTORC1 Rag-Ragulator-dependent mTORC1 activation in response to amino acid RHEB TSC2 PMC6641558__F3 The proposed pathway for constitutive AhR signaling and crosstalk with Src AHR AHRR SRC PMC7038996__F7 Two-step mechanism for SSB end resection in SSB repair and signaling.Step 1: An SSB is recognized by APE1, which then initiates SSB end resection in the 3′–5′ direction to generate a small gap (this work) ATR PCNA SSB PMC4051134__F5 Targeting JAK2 in the therapy of myeloproliferative neoplasms PIM2 PIM1 EPOR PMC6120446__F7 Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood SYK MYB MAFK BAD BCR CLU MYCL CD19 PTEN ME1 PMC3334621__F7 IsomiRs and miRNAs target similar biological pathways MAX BAX RAN ATR JUN BAD CD2 FAS OCEL1 CRK ISL1 MAP3K7IP1 HIPK2 NF1 RS1 ATM HEL-S-11 GRB2 LEF1 FADD PMC4051134__F3 Targeting JAK2 in the therapy of myeloproliferative neoplasms EPOR EPO PMC7721612__F9 RNA sequencing analyses reveal differentially expressed genes and pathways as Notch2 targets in B-cell lymphoma RPTOR PIK3CA JUN LTA FZD2 NCF2 PIK3R3 NFATC1 MTOR PPP3CA SH2D2A TNF NCK2 FOS PPP3CC CSF2RB FYN BCR ELMO1 HSF1 NFKBIA NLK SRC TRAF2 PMC6120446__F6 Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood CRP MPL FAS CD14 NLK TNF DAO FLNA MEF2C PMC7086007__F1 Pathogenic mechanisms of CRP causing inflammation and renal fibrosis in diabetic nephropathyCRP binds to FcGRII and activates the NFKB signal pathway to induce inflammation CRP MTOR PMC9321586__F3 Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation STAT2 HEL-S-62p EBP IRF9 MAPKAPK2 TAB3 IRAK2 MTOR SOCS3 MINK1 TRAF6 RAC1 IRS1 TSC2 TSC1 MAP3K7IP1 CCND1 PMC5668671__F2 Toll-like receptor signaling TLR1 TIRAP TLR3 TLR4 TLR9 TLR5 IRF3 TLR7 MYD88 PMC7086007__F3 NLR signaling pathways in diabetic nephropathyThe NLRP3 inflammasome can be activated by the ROS/TXNIP/NADPH oxidase signaling pathway and extracellular ATP, and inhibited by IL-22 NLRC4 IF2B1 NLRP3 TXNIP NOD2 NOD1 IL1B CARD9 PMC5668671__F5 HPVs infect host epithelial cells through TLRs EGF EGFR MTOR PMC2639789__F9 Summary diagram of E2 regulation of Wnt/Beta-catenin signaling pathway after cerebral ischemia and proposed role in E2 ischemic neuroprotection JUN DKK1 GSK3B WNT3 PMC12134342__F3 Tumor-associated neutrophil oncogenic mechanisms STAT3 S100A8 FAM3C IRS1 SPP1 MPO PMC12134342__F4 Tumor-associated neutrophil tumoricidal mechanisms FAS TRPM2 HGF SIRPA CXCL2 QPCTL CD47 MPO PMC3902172__F7 In vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis DLL4 MSC NOTCH2 HES1 NOTCH1 PMC12134342__F5 Interactions of tumor-associated neutrophils with other cells in the tumor immune microenvironment PANX1 IL1R1 CCL4 CXCL2 ARG2 PMC6797988__F6 Inhibitory effect of glycyrrhizin on ferroptosis during acute liver failure functions by promoting the Nrf2/HO-1/HMGB1 signaling pathway TF HMGB1 GPX4 PMC9445553__F6 Immune responses to different Uropathogens call individual interventions for bladder infection EGFR HBD CXCL2 RNASE7 CCL2 CCL20 PMC3225017__F2 c-MET signaling adaptors and mediators STAT3 CRK CBL HGF GRB2 SRC PMC3225017__F3 c-MET transactivation CD44 HGF PI3 GRB2 SRC PMC8146627__F1 Interrelationship between pregnancy, venous thromboembolism, and thyroid disease: a hypothesis-generating review TF TFPI PLG PMC10474868__F1 Polyhydroxylated Fullerene C60(OH)40 Nanofilms Promote the Mesenchymal–Epithelial Transition of Human Liver Cancer Cells via the TGFB1/Smad Pathway CDH2 SMAD2 SMAD4 PMC12098228__F2 Baicalein and baicalin significantly influences apoptosis in colorectal cancer cells BAX PCNA MMP2 MMP9 CCNB1 GADD45A CCND1 PMC11201817__F2 The influence of curcumin on mammalian DHA synthesis pathway and its neuroprotective effect [61] FADS2 IL6 BDNF TNF PMC12098228__F3 Baicalin inhibits colorectal cancer metastasis by targeting key migration and invasion pathways CDH2 CD44 BAX CCNE1 SOX2 CCNB1 CCND1 PMC5343289__F2 Crosstalk between autophagy and inflammatory signaling pathways: balancing host defence and homeostasis STAT3 TBK1 CGAS MAVS ATG16L1 ULK1 TUFM MYD88 IFNG NLRX1 NLRP3 EIF2A JAK1 IL1B PMC12098228__F1 Baicalein and baicalin suppressing proliferation in colorectal cancer BAX PCNA DKK1 MDM2 MTOR CCND1 CDK4 CTNNB1 PMC6577427__F1 NAD+ salvage pathway in mammals NRK NAMPT PMC9408924__F5 Differentially CTCF-Binding Sites in Cattle Rumen Tissue during Weaning BAMBI THSD4 E2F4 SKP1 NODAL ARHA PMC10740672__F8 Growth suppression mediated by p53 RHEB TSC2 TSC1 PTEN PMC10973673__F1 Crosstalk between non-coding RNAs and cell-cycle events: A new frontier in cancer therapy CDC2 SSBP1 ATR APC E2F5 CDK6 GSK3A E2F4 WEE1 CDK2 ATM SIRT1 CDK4 PMC7878365__F3 Sestrin modulates cell signaling networks in physiological responses to environmental stresses KEAP1 ULK1 SMAD2 SESN3 SMAD4 ATF4 SESN1 EIF2A SESN2 XBP1 PMC3205232__F1 A brief survey of mRNA surveillance DCP2 RAI1 DCPS NUDT16 PMC5782799__F5 Gene interaction network UBC IL4 PTMS CCNA2 ZBTB16 ZZZ3 ZDHHC13 PMC9157790__F2 Wnt Signaling in the Breast: From Development to Disease RNF43 DKK1 APC GSK3B LRP5 ZNRF3 LRP6 GPR49 WIF1 CTNNB1 PMC3321453__F6 Vitamin D pathway and sites of interaction with dietary factors NR1i1 CYP24A1 PTH PMC6081565__F1 Two classic pathways of necroptosis TRADD MLKL TNF PMC9157790__F4 Wnt Signaling in the Breast: From Development to Disease SFRP5 RSPO4 DKK4 FZD7 LRP5 LRP6 SFRP1 CTNNB1 DKK3 DKK1 GPR49 WIF1 LGR6 PMC9445553__F4 Immune responses to different Uropathogens call individual interventions for bladder infection HMGN2 TLR4 NOD2 RNASE7 PMC9405604__F4 Depletion of Mdig Changes Proteomic Profiling in Triple Negative Breast Cancer Cells ELF4 RPS6 OS9 EBP TRAF2 ELF3 PMC5800786__F4 Metabolic Regulation of Immune Responses IL7R MTOR TRAF6 PMC4428658__F3 Eculizumab and Recurrent C3 Glomerulonephritis C6 C7 C9 PMC4731654__F3 Wnt signaling pathway LRP5 LRP6 CTNNB1 PMC8450343__F6 Differential Expression of Immune Response Genes in Asymptomatic Chronic Chagas Disease Patients Versus Healthy Subjects CD40 IFNGR1 FAS CSF2 CSF1 IL12A CD27 IL27 IL6 TNF IL5 TBX21 HAVCR2 IFNG STAT1 IFNGR2 IL18 IL2 BCL2 IL7 IL12B PMC4624297__F4 Comparison of typical innate immune signaling cascades (top panel) with those activated by CJD infection (bottom panel) STAT1 STAT2 IFNAR2 IRF9 IFNAR1 IRF3 MX1 ISG15 CXCL10 PMC4650800__F5 Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling TGFB1 MMP3 MMP9 PMC7999177__F2 Transcriptomic alteration-based identification of potential diseases and functions modulated upon leptin upregulation SAA1 LEP CCL11 MMP12 CXCL5 CTSK PTGS2 MMP9 IL1A IL6 FGF7 MMP3 LCN2 PMC3349255__F7 Schematic diagram of a cross-regulation network between FOXA1 and the ErbB2 signaling pathway in ER-negative breast cancer FOXA1 TLE3 PAK1 RELB ERBB2 CREB1 FOS PMC2712597__F6 Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways RHD MOCS3 URM1 PMC4498776__F6 Global Transcriptomic Profiling of Cardiac Hypertrophy and Fatty Heart Induced by Long-Term High-Energy Diet in Bama Miniature Pigs ECSIT EGF FAS CR1L EGFR CD14 SIX4 ATF2 PPP3CA TNF TRAF6 MOS NFIB ATF4 GCK TRAF2 IL1B PMC2712597__F1 Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways NEDD8 GABARAP SUMO1 SUMO3 ATG3 UFM1 ATG12 UBA6 GABARAPL2 ISG15 PMC7354691__F4 Interaction network downstream of Atoh7 HELLS PRPF38A CTTNBP2 RSRC2 MRPL43 BOP1 NME6 COPA PAPOLG ATOH7 NELFA COX17 TRMT61A SYMPK CISD1 IPP COL1A1 ZNF217 SMC2 WASF2 PMC7503925__F6 Pigment-type switching controlled by dual signaling from MC1R MC1R MGRN1 ASIP MB PMC3124513__F6 Integrated Bio-Entity Network: A System for Biological Knowledge Discovery CEBPA TPM3 FPR1 IL2 PTK2B KCNK3 PMC3960869__F2 Interaction of Neisserial surface molecules with the complement system C6 C7 HEL-S-62p C2 C9 PMC4073605__F7 Proposed model for the formation of reactive oxygen species at mitochondria, activation of Nrf2, and regulation of phase 2 gene expression in the nucleus KEAP1 PI3 MAF PMC2768581__F2 Role of Cross Talk between PI3-Kinase and ERK/MAP Kinase Pathways in Artery-Vein Specification EPHB4 FOXC1 SHH PMC2858157__F6 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration RAD18 JUN TRIOBP FRS2 SLC9A3 AIM2 ZNF274 TRAF3 TCERG1 MZF1 ZNF675 CCNO BRCA1 CHEK2 GABPB2 MCM6 FADD PMC5980236__F1 Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells IPP MVP MVK PMC3747497__F1 FGF signalling: diverse roles during early vertebrate embryogenesis FRS2 GRB2 SRC GAB2 PMC2858157__F7 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration BRIP1 PYHIN1 CABL1 DNAJB4 PERP DTL ELL BRAF KIF20A TCF21 NPAT LATS1 TMF1 BCCIP EIF1AD NR2A1 POLR3E LCMT2 BRCA1 PELO RPS25 PMC2858157__F8 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration HDAC3 EMP1 AURKA E2F2 DDX11 CDC6 CASP3 CLSPN PRIM2 CCNA2 PMC2858157__F9 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration HDAC3 EMP1 FZR1 PCNA DNAJB6 E2F2 CDC6 DTL CLSPN EPO PRIM2 CCNA2 PMC6930397__F5 Functional protein interaction network of PLOD family genes PLOD1 FBN1 PPIB COL9A1 SPARC ADAMTS3 COL14A1 PCOLCE COL3A1 BMP1 COL9A3 SOX9 CRTAP COL16A1 PCOLCE2 MMP2 COL12A1 PLOD3 PLOD2 COL9A2 ADAMTS2 DCN PMC2592809__F9 Scheme summarises different intracellular pathways during osteoblast differentiation which include promoting (blue) and inhibiting (red) factors and are mainly mediated by Smad proteins ACTR2 WNT3A EBP BMP2 SMAD6 HEL-S-11 DLX5 RUNX2 SKI DLX3 MSX2 CTNNB1 PMC4654378__F2 NOX system is central to host defense CSA2 NLRP3 NOD2 VCAM1 DUOX2 NOX4 IL1B NDP PMC9231311__F4 Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants IFNG GSDMD COX1 PMC6363620__F3 Complex interplay between CCT and actin and tubulin DYNAP PMC12243265__F9 RGCs damage in glaucoma were ameliorated via Gut microbiota-IAA-eye signaling pathway AHR IL6 MB IL1B PMC5323256__F8 Glycogen Synthase Kinase-3B Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3 NGF IGF1 GSK3B PMC4820873__F6 Schematic model of IGF1R-evoked and p110Beta-evoked resistance to p110A inhibition in PIK3CA mutant breast cancer cells PIK3CA IGF1 IGF1R MTOR IRS1 PMC3562627__F2 EGFR monoclonal antibodies (MoABs) cetuximab/panitumab, and BRAF inhibitors in BRAF mutated colorectal cancer EGFR BRAF KRAS PMC4381257__F1 Important ECM molecules and ECM receptors involved in cancer cell invasion CD44 MMP2 HEL-S-28 RHO MMP9 PMC6724557__F1 TNFR2 can modulate TNFR1 signaling TRADD TRAF2 FADD PMC6724557__F3 Model of TNFR2-mediated regulation of NFKB transcriptions factors in Tregs RELA RELB TRAF2 PMC6768886__F7 MiR-532-3p suppresses colorectal cancer progression by disrupting the ETS1/TGM2 axis-mediated Wnt/Beta-catenin signaling FZD7 LRP5 LRP6 LEF1 CTNNB1 PMC2374711__F5 Proposed model of APL pathogenesis induced by PML-RARA BCOR MYBL2 PML TCERG1 RORA CHD9 RARA UBTF STAT5B SPIB ETV4 ATF1 EGR1 USF1 FOS RUNX1 FOXO1 ACTL6A RXRA NFYA STAT4 NFYC EGR2 ARID5B LEF1 SND1 BCL6 PMC9250635__F1 CGAS activation and cGAS-STING signaling TBK1 CGAS IRF3 PMC9250635__F2 CGAS activity in cells CGAS CASP5 CASP4 PQBP1 CASP3 TREX1 ZCCHC3 PMC3649977__F2 STL-based Analysis of TRAIL-induced Apoptosis Challenges the Notion of Type I/Type II Cell Line Classification C6 BAX BCL2 PMC6542701__F2 ER’s coregulatory proteins and genomic binding sites differ between endometrial cancer and breast cancer cells TF GREB1 FOXA1 ETV4 GATA3 PMC5549027__F15 Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway BAX MTOR PMC11502381__F2 Bidirectional regulation of the cGAS-STING pathway and immune cells in the tumor immunosuppression microenvironment (A) The cGAS-STING pathway inhibits M2 macrophage polarization and promotes anti-tumor immunity STAT3 NOS2 CGAS CCR2 CCL7 TFEB FOXP3 CCL2 PMC8657039__F2 Early TP53 Alterations Shape Gastric and Esophageal Cancer Development ATR WEE1 ATM PMC5442340__F4 KEGG pathway for Hippo signaling pathway LATS1 RASSF6 LATS2 AFP SOS2 AMOT AREG MYC CTNNB1 PMC7263595__F1 Intragenic suppressor mutations of the COQ8 protein kinase homolog restore coenzyme Q biosynthesis and function in Saccharomyces cerevisiae COQ7 COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 PMC5442340__F5 KEGG pathway for PI3K-Akt signaling pathway BAD RBL2 PTEN MTOR MYC RAC1 TSC2 BCR CD37 PI3 RXRA MEI1 GRB2 PMC5082287__F3 Pathway depicting Beta-hydroxy-Beta-methylbutyrate (HMB)-modulated genes identified in the present analysis, which could directly or indirectly affect skeletal muscle cell functions SAA1 LAMA5 SVIL HACD1 ZFP91 F2R ITGB1BP2 TAGLN3 MYF5 DMD FADS1 MEF2C PMC6981772__F2 Plant sterol and cholesterol metabolism LPL APOO ACAT2 ABCB4 APOE PMC4631354__F3 Characterization of SCDs as Membrane Maintenance Regulators FAT4 FAT1 FAT2 FAT3 PMC5082287__F5 Relevance network over-viewing discussed relationships between Beta-hydroxy-Beta-methylbutyrate (HMB)-modulated genes and cell processes (Pathway Studio Web Mammalian) ESRRA NOS2 ABHD5 DMD PMC9369281__F2 MicroRNAs in Inflammatory Bowel Disease and Its Complications SOCS1 STAT3 PDLIM2 PTEN PMC5539204__F6 Complexity of the miRNA-mRNA interactome network in rat soleus muscles with cardiac cachexia MMP16 ITGB1 SMOC2 COL22A1 TLN2 PMC4107940__F1 General interplay between the canonical TLR signaling pathway, the cytokine-mediated DNA repair feedback loop, and the growth factors-mediated signaling pathway ERCC1 STAT3 XPA HMGB1 RAD51 TIRAP MAL TYMS MYD88 OGG1 XRCC5 STAT1 BRCA1 STAT4 GRB2 PMC7470101__F1 Role of cytokines in mediating communication between immune cells IL15 IL10 IF2B1 IL13 IL3 IL27 IL4 IL6 IF2G IL5 IL-21 IFNG IL25 IL24 IF2D IL18 IL2 IL7 IFNB1 PMC8247566__F2 MiR-126 pro- and anti-angiogenic function in different cell-types RPE S1PR2 PIK3R2 VCAM1 PMC3448682__F7 Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis GBP4 CD40 MEFV PIM1 UBE2L6 TNFAIP2 TRAFD1 IFNB1 IL15RA OAS1 OAS2 PMC10985261__F12 The VDR-mTOR Signaling Pathway in DKD Development NR1i1 DDIT4 MTOR PMC4676991__F2 Autophagic signaling pathways associated with oxidative stress TSC2 TSC1 ULK1 FOXO3A UVRAG BNIP3 ATM PTEN PMC7098960__F2 The immune response induced by polygenic diseases related to the composition of the intestinal microbiota in patients with IBS and healthy subjects MGAT5 STAT3 TIRAP NOD2 TLR7 IL10RA TRAF6 IL23R TYK2 IL12RB1 PMC8058464__F1 Transcriptional signature of Leishmania infected macrophage FAS IL4 MTOR SIRT1 PMC6057036__F7 RASAL2-mediated hippo signaling pathway LATS1 LATS2 CCND1 YAP1 PMC6836336__F3 GREM1 expression is associated with genes involved in collagen formation and extracellular matrix (ECM) organization PDPN AEBP1 MMP14 THBS2 SPARC CTHRC1 GLT8D2 SRPX2 DPYSL3 RARRES2 NOX4 POSTN INHBA LOX MMP2 ADAM12 ADAMTS12 TNFAIP6 FBN1 P4HA3 ANGPTL2 CTSK FOXF2 FAP PRRX1 VCAN GLIS3 LOXL2 MSRB3 BMP1 DKFZp686P11128 ADAMTS2 PMC9598787__F7 Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation TRADD MCL1 SOCS3 PMC4254277__F2 Protein and Amino Acid Restriction, Aging and Disease: from yeast to humans ATF4 MTOR PMC11011407__F2 Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies CDC42 EPHB2 EPHA2 FGFR1 RRAS EPHA4 MTOR RAC1 FGF2 PMC11011407__F3 Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies EPHB4 EPHB2 EPHB1 CDK4 PMC11011407__F4 Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies EPHA2 EPHA7 PMC6403468__F13 Model of ApoER2 and VLDLR mediated signaling during cortical development DAB1 DCC CP PMC3897553__F8 Neural Epidermal Growth Factor-Like Like Protein 2 (NELL2) Promotes Aggregation of Embryonic Carcinoma P19 Cells by Inducing N-Cadherin Expression CDH2 SP1 PMC10526485__F2 Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human Diseases MICU1 MCU MCUB EFHA1 MICU3 PMC7294139__F3 Gene ontology and pathway enrichment and network analysis of blue module genes CXCL12 MMP14 TIMP3 TGFBI P4HA2 THBS2 PCOLCE COL3A1 VCAN POSTN LOX COL22A1 DCN PMC11016919__F1 Trimetazidine May Potentially Confer Neuroprotective Effects against COVID-19-Induced Neurological Sequelae via Inhibition of Death-Associated Protein Kinase 1 (DAPK1) Signaling Pathways: An Evidenced-Based Hypothesis BAX PTEN BDNF PMC6694821__F6 Protein interactome of genes downregulated upon productive HPV16 infection of epithelial tissue types NDRG2 FUT2 FUT3 TAP1 ERN1 MAP3K8 FYN PLCG2 NDN RIT1 HEL-S-26 TM7SF2 SAA1 VAV3 MMP10 IRF9 JMY B2M IRF7 OAS3 ERBB3 HBEGF COL18A1 UGDH LCN2 TCN1 HLA-A CCL20 F11R RGS2 TGFA PTK6 NFKB2 CXCL1 NR1C2 PRKCH DHRS9 MX2 AMFR MX1 ISG15 OAS1 CALB2 OAS2 MYO6 CTH SP110 FLG XAF1 SERPINE2 MAFF PTGES TNFSF10 CGA VLDLR ST3GAL1 SP100 OASL ALOX12 PLA2G7 AMACR GAS7 S100A4 IFITM2 FOSB IL18R1 SLPI LAMC2 NAMPT KLK3 RSAD2 EPHA1 PCK2 GPX2 PTHLH BTG2 GPNMB HFE RNF144B SLC40A1 GAS INA IFIT1 IFIT3 IFIH1 SMOX RORA IFI44L RPTN SPNS2 YOD1 LCE1E HLA-F PPBP HLA-G LCE1D LYPD2 IL36RN HELZ LYPD6B TMPRSS11D TNFRSF21 HEL-S-52 TYMP TPD52L1 IL1B TJP3 UBC GAL CGN NLRP2 NTM PARP1 PDK4 IL36G ASNS GAB2 CLDN1 PMC7423683__F4 Notch and the Regulation of Osteoclast Differentiation and Function NOTCH2 NOTCH3 HES1 NOTCH1 IL1B PMC12045470__F5 Sepsis-induced liver injury GPX4 TLR4 HEL-S-44 PMC12045470__F6 Sepsis-induced myocardial injury HMGB1 NLRP3 GPX4 TLR4 NOX4 PMC12045470__F3 Sepsis-induced lung injury HMGB4 FTH1 NLRP3 TLR4 TNF PMC12045470__F4 Sepsis-induced kidney injury NLRP3 GPX4 TLR4 SLC7A11 NOX4 HEL-S-44 PMC9324529__F1 Immunosuppressive Mechanisms in Brucellosis in Light of Chronic Bacterial Diseases CD80 TLR4 EGFR TLR8 PMC8899123__F3 Molecular Docking as a Therapeutic Approach for Targeting Cancer Stem Cell Metabolic Processes OXCT1 SUFU SHH SKP1 SMO MTOR SKP2 PMC4099420__F6 Gene Expression Profiling of the Response to Interferon Beta in Epstein-Barr-Transformed and Primary B Cells of Patients with Multiple Sclerosis SOCS1 ADAR SYK DGIC IFIT1 IFIH1 TLR9 IFIT2 TRIM21 MYD88 ISG20 APOBEC3F OASL MX1 TLR7 OAS1 OAS2 EIF2AK2 IL27RA TRIM5 APOBEC3G IFNGR1 AIM2 IRF7 OAS3 IRF8 c-fgr PMC8017232__F7 Proposed model depicting the involvement of TIPE2 in the RIG-I signaling pathway TBK1 MAVS IRF3 PMC12045470__F2 Protective mechanism of dexmedetomidine against multiorgan dysfunction BAX HMGB1 GSDMD NLRP3 TLR4 MTOR TNF NOX4 HEL-S-44 PMC10374575__F6 GHS-R1a/D2R heterodimers activation in dopaminergic neurons TH GAL PMC4179756__F13 Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27 HTRA2 PMC4071201__F1 Depiction of the systematic procedure to study drug resistance in MM BAX TGFA MAP3K1 IGF1 TLR4 EGFR MAP3K7 GRB2 MTOR TRAF6 TRAF2 IRS1 PMC4071201__F2 p38 MAPK isoforms for drug resistance BAX RAI1 PC MTOR SHE IRS1 PMC8498061__F2 Myricetin: A comprehensive review on its biological potentials STAT3 EGF EGFR MTOR HIRA PMC9201453__F2 Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases DIO1 TGFBI SP1 PIM1 SMAD2 MMP3 CDK2 PMC9201453__F3 Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases TRIP13 NDRG2 THRSP PDGFA PMC7056742__F2 Activation of NLRP3 inflammasome has involved in the pathogenesis of several renal diseases including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy (DN), IgA nephropathy (IgAN), etc NLRP3 IL1B FADD PMC4620942__F5 Modeling the calcium-mediated pro-apoptotic action of less toxic natural products INSR DDIT3 ATF4 EIF2A PMC10520667__F7 LncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: A Boolean model of cell death BMI1 ULK1 MTOR PMC4184083__F1 Addition of RASAL1 to the canonical scheme of the RAS-coupled MAPK and PI3K pathways RASAL1 BRAF PTEN MTOR PMC4601496__F1 Manipulation of neutrophil function by P MAL MYD88 PMC3627065__F8 Factors situated at the interface between the ubiquitin-proteasome and the autophagy-lysosome degradative systems BAG3 BAG1 MTOR PMC3627065__F6 Integrated view of mammalian autophagy ATG10 ATG3 ATG12 UVRAG AMBRA1 ATG14 BCL2 ATG5 PMC3829803__F7 Retinoid action during paramyxovirus infection MAVS IFNAR2 IRF9 IFNAR1 IRF1 IRF7 PMC3954580__F5 MEK5/ERK5 Pathway: The first fifteen years CDH2 STAT3 EGF SNAI2 BAD FOXO3A LIF IL6 SRC MEF2C CTNNB1 PMC9266688__F8 Tumor-Suppressor Role of the A1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma FOXO1 EGFR MTOR SRC PMC6377309__F1 SAMHD1 down-regulates the IFN-I pathway TBK1 CGAS RIGI IRF3 PMC6377309__F2 SAMHD1 prevents the activation of NFKB signaling RELB IRF1 TNF PMC1764624__F1 Synthesis and breakdown of proteins by amino acids MTOR IRS1 EIF4E PMC6377309__F5 Role of SAMHD1 in the crosstalk between innate and adaptive immune responses APC PMC10222038__F1 Vitamin D metabolic pathway CYP2R1 CYP27B1 MOK PMC4543607__F1 Major EDCF-mediated signalling pathways in hypertension and diabetes COX1 RHO PMC8479196__F3 Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy LPO CD36 FASN PMC8479196__F1 Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy CD36 FASN MSC PMC3091682__F2 Correlation of Predicted miRNA Targets with Hosts CSA2 SRD5A2 CASP9 BAD PDGFA PTEN MTOR RB1 FOXO1 CDK2 MAP2K1 MDM2 GRB2 PMC9513149__F1 DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology ATR CDK6 CDK2 ATM GATA4 CCND1 CDK4 PMC9201453__F4 Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases USP18 TRIP12 PMC4177605__F3 PPAR signaling pathway from KEGG LPL UBC UCP1 PLTP PMC3954580__F2 MEK5 regulation and downstream targets EGF SNAI2 NGF BAD FOXO3A LIF IL6 ZEB2 SRC BDNF FOS PMC5352205__F8 Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness BRAF MMP9 PMC5863775__F1 MST2-RASSF protein–protein interactions through SARAH domains LATS1 ARAF LATS2 FAS MDM2 KRAS PMC8694249__F1 Phosphatases of regenerating liver are key regulators of metabolism in cancer cells – role of Serine/Glycine metabolism GLDC PHGDH PRL PSAT1 PTEN PSPH PMC4162761__F1 Biosynthesis and Roles of Phospholipids in Mitochondrial Fusion, Division and Mitophagy PGP GPAT2 CDS1 GPT2 PC PMC5325784__F2 HPV E6 and E7 interacts with core components of the interferon pathway CGAS STAT2 IRF9 TANK IRF1 IRF3 IRF7 TRAF3 HEL-117 STAT1 IFNAR2 IFNAR1 JAK1 PMC6423448__F1 Key components of the Hippo pathway in Drosophila and mammals LATS2 NF2 PMC6006200__F2 Fe/S cluster biogenesis CFD PMC2886068__F2 Bile salt synthetic pathways CYP7A1 HSD3B7 CYP27A1 PMC7568356__F3 CircRNA-miRNA-mRNA networks in hematological malignancies FZD3 CCND1 CTNNB1 PMC3387579__F1 De novo DAG/TAG synthesis (Kennedy pathway) LPA DAG1 FAS PMC6691039__F1 Platelet Theory SYK LAT PMC4018451__F1 The IRS-1→PI3K→Akt insulin signaling pathway TSC2 BAD FOXO3A PTEN PDK2 IRS1 PMC4018451__F2 Schematic summary of hippocampal formation alterations in the IR→IRS-1→PI3K→Akt→mTOR signaling pathway of AD dementia cases versus age- and gender-matched controls TSC2 TSC1 GSK3A PTEN PDK2 MTOR IRS1 PMC6691039__F2 Endothelial theory VWF PMC8460702__F5 Growth hormone promotes hepatic gluconeogenesis by enhancing BTG2–YY1 signaling pathway BTG2 YY1 PCK1 PMC5346332__F3 Role of Aim2 protein in non lupus-prone and lupus-prone strains of mice in the regulation of type I IFNs production TBK1 IFNAR2 IRF9 IFNAR1 AIM2 IRF3 IRF7 PMC8034456__F8 The beneficial effects of FGF19 on muscle atrophy, metabolic homeostasis and irisin secretion in skeletal muscle FGF8A TFAM MYOG UCP1 NRF1 IRS1 PMC8155122__F3 Biased signaling of oxycodone and morphine EGFR TRPV1 HEL-S-34 PMC7198830__F1 Direct cardiotoxic effects of anti-cancer therapies in cardiomyocytes BAD ERBB4 ERBB2 MTOR SRC PMC9060002__F7 Data suggest multiple potentially active epithelial–mesenchymal transition-associated pathways in CF, with YAP1 mediating their crosstalk HSP90AB1 HEL-S-133P S100A8 CFTR MYC LEF1 PMC9706580__F8 Mutant Kras and mTOR crosstalk drives hepatocellular carcinoma development via PEG3/STAT3/BEX2 signaling STAT3 BEX2 TSC1 PEG3 MTOR KRAS PMC5346332__F1 Constitutive low levels of IFNB that are produced by most cell types “prime” type I IFNs producing cells for a robust type I IFNs production upon sensing “danger” signals such as cytosolic DNA and TLR ligands TBK1 STAT1 CGAS STAT2 IFNAR2 IFNAR1 IRF3 IRF7 TYK2 PMC10594068__F3 Bone is a tissue that consists of diverse cell types (osteoblasts, osteoclasts) that interact in a complex manner MSC PTH PTH1R PMC6094638__F3 Anti-inflammatory function of tumor necrosis factor receptor-associated factor (TRAF)2 and TRAF3 in toll-like receptor (TLR) signaling pathway MAP3K7IP1 TAB3 RELA TRAF3 TRAF6 PELI1 TRAF2 MYD88 PMC4148386__F3 MAPK signaling pathway MAX FAS TGFB1 RASGRP3 CD14 NLK KRAS FLNA TGFBR1 PMC8327900__F1A What Are the Clinical and Systemic Results of Periodontitis Treatment in Obese Individuals? NR1C1 APPL1 INSR ADIPOR1 ADIPOR2 PMC6407861__F1 Assembling a protective shield SHLD1 BRCA1 ME2 RIF1 SHLD3 SHLD2 PMC8928443__F4 Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations STAT3 MAP2K4 PC PTEN MYD88 PMC6094638__F1 Function and regulation of tumor necrosis factor receptor-associated factor (TRAF)6 in MyD88 signaling pathway MAP3K7IP1 MYSM1 USP4 OTUD7B TAB3 USP20 TRAF6 CYLD MYD88 PMC7125957__F1 B9 metabolism comprising the thymidylate cycle (red diagram), the methionine cycle (green diagram) and the purine biosynthesis pathway (blue diagram) VIT DHFR PMC7125957__F2 Vitamin B6 metabolism in humans PNP HEL-S-302 HEL-S-1a PMC10966134__F8 Schematic illustrating the proposed mechanism by which the PERK pathway modulates autophagy during RACK1‐mediated neuroprotection after TBI ATF4 EIF2A ATG5 PMC6657611__F2 Notch-targeting therapeutic approaches in TNBCs NTM NOTCH2 NOTCH3 NOTCH1 PMC5138043__F2 FAT4 participates in tumor transformation through the Hippo–Wnt signaling pathway by inducing YAP–TAZ activation.Notes: Src-mediated tumorigenesis also results from Src activation to repress FAT4 gene expression via MEK/ERK or cofilin1 FAT4 FOXK1 APC SRC CTNNB1 PMC8216017__F1 CXCL12 in Kidney Diseases: A Friend or Foe? CXCL12 SHH CXCR4 PMC8216017__F2 CXCL12 in Kidney Diseases: A Friend or Foe? TEC CXCL12 BAD DPP4 CXCR4 PMC9004567__F5 Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine CXCL12 HGF KDM7A MTOR CHAD INS MYC ITGAV SPP1 IGF1 CHUK ITK JAK1 PMC7201649__F10 Copper Induces Oxidative Stress and Apoptosis in the Mouse Liver FAS TRADD AHR TNF FADD PMC9001970__F1 Evolving Roles of Notch Signaling in Cortical Development JAG2 NOTCH2 NOTCH3 NOTCH1 PMC3544113__F1 Main deregulated signaling pathways in PMBCL SOCS1 MAP3K14 TNF PMC6584414__F1 Schematic illustration of albumin nanoparticles preparation and their targeted delivery to breast cancer cells and metastatic lymph node NPS SPARC SMO PMC6367250__F1 The roles of circRNAs in cancer phenotypes and biological characteristics TIMP3 FOXO3A CTNNB1 PMC4894443__F4 Flatworms have lost the right open reading frame kinase 3 gene during evolution RIOK3 LTV1 NOB1 RIOK2 PMC5240838__F8 Proteostasis network via the HSF1-SQSTM1 axis TBK1 HSF1 SQSTM1 PMC6944215__F5 Representation of the adverse outcome pathway (AOP) network involving BPF CDK6 GPER CCND1 CDK4 PMC10384765__F6 Exploring the Molecular Basis of Vesicular Stomatitis Virus Pathogenesis in Swine: Insights from Expression Profiling of Primary Macrophages Infected with M51R Mutant Virus TRIM38 IFNA17 STAT2 IRF9 IFNA4 IRF3 IFNA2 SOCS3 FOS TRIM21 IFNG IFNK TRIM25 IFNAR2 IRF2 AHR PMC10474147__F2 Necrosis and apoptosis: morphological features and signaling pathways BAX CASP9 CASP8 TRADD CASP3 CASP10 FADD PMC3941921__F3 Highest-scoring downregulated network: Energy Production, Metabolism and Cell Structure SLC25A4 PFN1 CAMK2D HEL-S-1 ATP1A1 SLC8A1 HEL2 YWHAZ PMC3941921__F5 Downregulated network of CANB1 in traumatic brain injury (TBI) PPP3CA PPP3R2 PMC6678366__F4 Molecular mechanism of soft-jet plasma-induced cancer cell apoptosis via the mitochondrial intrinsic pathway and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activation BAX H2AX PMC7667085__F1 Pseudomonas aeruginosa injection (PAI) make the naïve T cell mature through both CD80/86 and MHC-II signal pathway in dendritic cells (DC) CD80 PMC2788936__F3 Signaling and regulation of PRR-induced autophagy TLR4 IL18 MYD88 PMC3941921__F2 Highest scoring upregulated network: Cellular Assembly HEL113 INA PLEC MYH9 ERMN MAP2 NEFL SYN1 NEF3 LMNA NEFH PMC11484394__F2 Diagram illustrating the regulation of the p53 pathway by miRNAs in prostate cancer (WP3982) BAX CASP9 SIAH1 CASP8 PERP PTEN BBC3 MTOR PMAIP1 CYS1 ZMAT3 IGF1 TP53AIP1 SESN3 CASP3 CHEK2 ATM MDM2 APAF1 PMC3784162__F2 Toll-like receptor 3 (TLR3) participates in both defence and offence in host immunity to viruses TLR3 IRF3 TRAF3 TRAF6 TRAF2 PMC4891224__F1 Is There a Future for AKT Inhibitors in the Treatment of Cancer? RPS6 TSC2 TSC1 PTEN CCND1 IRS1 PMC2784308__F1 An illustration of the MC1R pigmentation pathway and the loci implicated in melanoma risk MC1R ASIP TYRP1 PMC5399014__F6 Metabolic pathway of lipid accumulation in oleaginous microorganisms and related key enzymes FAS CS PMC4915479__F4 Major TGFB signaling pathways in vascular cells TBR1 ENG GSK3B CDK2 ATF2 RHO GRB2 NET1 SMURF2 TRAF6 LEF1 PMC7277712__F6 Bisphenol A-induced synthesis of steroids: The bisphenol A (BPA) spreads out through the membrane and binds the cytosolic multi-protein aryl hydrocarbon receptor (AhR), allowing its release in the cytoplasm by the heat shock protein (hsp)-90 STAR PBR AHR PMC3304564__F1 PI3K/AKT signaling module and cross-talk with other pathway RHEB BAX TSC2 PTEN PMC5846438__F2 Signaling pathways of different amino acids in intestinal inflammation CASR MTOR ACE2 PMC2905406__F10 Illustration of GDNF signaling disruption by coated silver nanoparticles FYN GDNF PI3 RET PMC5846438__F1 Possible signaling mechanisms of amino acids in intestinal inflammation in the ECs are illustrated CASR MTOR ACE2 PMC3658307__F2 Liver Ischemia and Reperfusion Injury: New Insights Into Mechanisms of Innate – Adaptive Immune-Mediated Tissue Inflammation CD40 CXCR3 HMGB1 TLR4 TLR9 STAT4 CXCL10 CCL2 CXCL8 IL1B CD1D PMC7396796__F1 Model representing the molecular signaling pathway of WAVE3 contributing to cancer progression and metastasis EGF SMAD2 RAC1 PMC10886137__F4 JNK and p38 MAPK signaling pathway of filefish upon Cd exposure JUND TRADD IL2 IL11 TNF TRAF2 MYD88 PMC8953253__F4 Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator STAT3 SOST WNT16 OSM OSMR GRB2 JAK1 PMC10886137__F5 Glycolysis pathway of filefish upon Cd exposure ENO2 HEL-S-49 HK2 HEL-S-162eP ENO1 GCK PMC10886137__F6 Fatty acid degradation-related pathways of filefish upon Cd exposure ACD CPT2 PMC10886137__F7 Citrate cycle (TCA cycle) pathway of filefish upon Cd exposure SDHD SDHA SDHB DLAT MDH2 PMC8914342__F3 Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases TFF1 CTCF ELAVL1 MDM2 IMPACT PARP1 PMC1386115__F3 Integration of lipid metabolic and inflammatory signaling in macrophages by LXRs ABCG1 COX1 TLR3 TLR4 NOD2 IRF3 MMP9 TNF ABCA1 IL1B PMC9103147__F3 Proteostasis Perturbations and Their Roles in Causing Sterile Inflammation and Autoinflammatory Diseases CGAS CGA IRF3 MDM2 PMC6024333__F2 Mechanisms of innate and acquired resistance to immune-checkpoint inhibitors (ICPIs) JAK1 CTNNB1 PMC7528619__F2 Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1 CGAS DDX41 IFI16 IRF3 CTNNB1 PMC7528619__F3 Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1 LAT IFNAR2 IRF9 IFNAR1 IFIT3 CH25H TYK2 PMC6627600__F1 Interactions between RHOB and EGFR, Ras, PI3K/Akt/mTOR, MYC, and HDAC HDAC1 EGF TGFA EGFR RHOB PTEN GRB2 MTOR MYC HDAC6 PMC7249724__F3 Micro-environment favorable for re-pigmentation PAX3 MC1R SMAD4 PC PMC10743093__F3 Schematic illustration highlighting targets of senotherapeutics including senolytics and senomorphics FOXO4 GPNMB MTOR PMC5749411__F4 Regulation of Granulosa and Theca Cell Transcriptomes During Ovarian Antral Follicle Development BAX BAD FAS TRADD C2 AIP ATM TRAF2 FADD MYD88 PMC7531836__F1 Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease C6 CD59 FH C7 HEL-S-62p C9 CR1 PMC5749411__F5 Regulation of Granulosa and Theca Cell Transcriptomes During Ovarian Antral Follicle Development TGFBI SMAD2 SMAD6 SMAD4 NODAL ARHA PITX2 IFNG RBX1 SMURF1 FST BMP4 SI SMURF2 PMC2396493__F1 P53 on the IGF-1 signaling pathway RICTOR IGF1 PTEN MTOR PMC8348034__F6 Cigarette Smoke Condensate Exposure Induces Receptor for Advanced Glycation End-Products (RAGE)-Dependent Sterile Inflammation in Amniotic Epithelial Cells HMGB1 IL6 IL1B PMC8450413__F5 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer PORCN APC CTNNB1 PMC2821977__F1 All steroids derive from cholesterol, which can be synthesized within the brain for de novo neurosteroidogenesis () STAR CYP11A1 PBR PMC9685566__F9 Transcription level differences in Taxus wallichiana var. mairei elicited by Ce3+, Ce4+ and methyl jasmonate CDC42 RAF1 MOS FLNA RAC1 PMC5442293__F1 Role of WIP1 phosphatase in termination of DNA damage response ATR CDKN1A ATM MDM2 CDC25B PMC7007436__F7 Pten-mediated Gsk3B modulates the naïve pluripotency maintenance in embryonic stem cells GSK3B PTEN MTOR PMC6698381__F3 Pathways involved in sphingolipid metabolism UGCG ACER1 GBA2 SGMS1 SPHK1 DEGS1 SGMS2 SMPD1 SMPD2 ASAH2 SPHK2 SGPP1 ACER3 PMC6471604__F1 Mucins: the Old, the New and the Promising Factors in Hepatobiliary Carcinogenesis MUC13 STAT3 BAX MUC15 HGF EGFR MEI1 MUC1 MB CCND1 AXIN2 CTNNB1 PMC8686517__F1 TNFA in MS and Its Animal Models: Implications for Chronic Pain in the Disease RIPK3 TRADD MLKL RIPK1 TRAF1 TRAF2 FADD PMC6425566__F3 Mitonuclear communication GRSF1 EGR1 EPO SIRT1 PARP1 PMC8450413__F1 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer RNF43 APC GSK3B ZNRF3 CDK14 LRP6 GPR49 CTNNB1 PMC8450413__F2 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer CDC42 JUN RYK ATF2 ARHA DAAM1 PMC6441546__F4 One-carbon metabolism GAA AS3MT HEL-S-20 SLC19A1 MTR PMC8450413__F3 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer TGFBR2 SMAD2 APC GSK3B LRP5 LRP6 SMO DKK2 SFRP1 TGFBR1 PMC11042222__F4 Loss of Ffar4 is associated with decreased AMPK signaling and increased cellular senescence in the infarcted myocardium ATR RAD50 FAS POC1A CD82 PTEN INS MRE11A HLA-G CIDEA CDK2 ATM MCU GATA4 CDK4 PMC8450413__F4 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer BCL9 ADAM19 ADAM10 MYC PMC9637639__F6 Identification of the effect and mechanism of Yiyi Fuzi Baijiang powder against colorectal cancer using network pharmacology and experimental validation CASP9 MSH6 BAD POLK APC MYC PMC3734838__F6 Schematic illustration delineating the role of the AKT/Foxo3a/Bim pathway in selenite-induced apoptosis of CRC cells PTEN SRC PMC7792222__F2 miRNA-mediated regulation of BCSCs via targeting the Wnt/Beta-catenin signaling pathway DKK1 APC AXIN1 LRP5 LRP6 TCF4 CCND1 CTNNB1 PMC10878789__F10 Schematic diagram illustrating the occurrence of asthma NLRP3 ATG9A ULK1 PMC7453253__F1 Imbalance of T cells in asthma pathogenesis IL25 TSLP FAS IL33 STAT4 FOXP3 BCL6 GATA3 PMC7528619__F1 Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1 TBK1 MAVS TLR3 TLR4 MAL TLR9 IRF3 TRAF3 GGH TRAF6 MYD88 PMC5176079__F1 Stress kinases in the modulation of metabolism and energy balance EEF2K JUND ATF2 IRS1 PMC10669090__F2 The influence of risk factors on the formation of peak bone mass SOST IGF1 RUNX2 CP PMC7247003__F2 Schematic presentation of key pathways activated in a colorectal cancer cell by three groups of cell membrane receptors EGF GAL GALR1 EGFR GALR2 GRB2 BDNF FADD PMC7499294__F1 ER stress-induced apoptosis in lesional macrophages and ECs FAS ATF4 EIF2A TRAF2 PMC7499294__F2 ER stress-induced inflammation in macrophages and ECs NLRP3 TXNIP ATF4 EIF2A TRAF2 PMC7793297__F13 Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells CD40 SAG RUNX1 TLR4 ELL TNF RUNX3 PMC7209958__F1 Is there a role for tau glutathione transferases in tetrapyrrole metabolism and retrograde signalling in plants? POR HMBS CPOX UROD UROS PMC3413046__F2 Integrated functional association analysis of protein and genetic interactions on alanine and aspartate GLDC ZNHIT3 HEL60 SGPL1 SPTLC3 GAD1 COQ9 HEL-S-51e ABAT GLUD1 SPTLC2 SHMT1 pcap PC AADAT HEL-S-26 GPT AGXT2 GOT2 KYNU GPT2 ALAS2 DDC ESRRA HDC NR2A1 AGXT PDXDC1 MOCOS PSAT1 PMC7792222__F5 miRNA-mediated regulation of the BCSCs via targeting the BMI-1 signaling pathway BMI1 MDM2 CDK4 PMC7792222__F4 miRNA-mediated regulation of BCSCs via targeting the PI3K/AKT/mTOR signaling pathway PTEN MTOR PMC5001910__F3 A guide to immunometabolism for immunologists IFNG NLRP3 HEL-S-162eP IL1B PMC7263313__F4 Targeting senescent cells to attenuate cardiovascular disease progression CGAS TREX1 DNASE2 PMC6727512__F3 Biosynthesis of AhR ligands from tryptophan metabolism CYP2E1 HEL-S-90n C2 PMC6727512__F1 AhR transcription in mammalian cells and the putative mechanism of AhR activation CYP1A2 POLL CUL4B POLI AHR AHRR CYP1B1 PMC3660516__F4 Statins Are Associated with Reduced Risk of Esophageal Cancer, Particularly in Patients with Barrett’s Esophagus: A Systematic Review and Meta-Analysis PI3 RHO RAC1 PMC4475795__F1 UPR signaling schematic SP1 SP2 ATF4 EIF2A PMC9032796__F3 Epitranscriptomics of SARS-CoV-2 Infection MGA JUN STAT2 IRF3 METTL3 PMC8231835__F1 MicroRNAs: The Link between the Metabolic Syndrome and Oncogenesis STAT3 TIMP3 HMGA2 FOXP4 SOX2 CTBP1 PTEN SRC CTNNB1 PMC9551057__F8 Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NFKB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus STAT3 IL10 APC MYD88 PMC3043796__F3 Proteins of signaling pathways activated by ET-1 are targets for O-GlcNAc HEL-S-11 ARHA RHO SRC PMC3043796__F1 Signaling pathways activated by endothelin-1 (ET-1) in vascular smooth muscle cells (VSMC) HEL-S-11 ARHA RHO SRC PMC11653592__F1 Main metabolic processes of estrogen HSD17B1 HSD17B2 CYP1B1 CYP1A1 CYP3A4 PMC3072047__F1 Carbon flux rerouting during Mycobacterium tuberculosis growth arrest HEL107 FAS DLAT TGS1 PMC11653592__F2 Mechanism of 16Alpha-OHE promoting pulmonary hypertension SOX17 BMPR2 SMAD1 DKFZp781O1323 CD36 SMAD2 APOE SMAD4 TNF ID1 NOX4 CCND2 PFKP COIL CCND1 HEL-S-44 PMC4854877__F2 Dynamic angiogenic signaling balance and angiogenic switch LPA PLCG1 PKD1 FYN CD36 PMC11653592__F4 4-OHE in pulmonary hypertension; 4-OHEs competitively decrease the activity of 2-OHE2, inhibiting the formation of 2-ME2 HEL-S-22 KEAP1 COX2 MTOR TNF PMC9078765__F5 Utilizing Network Pharmacology and Molecular Docking Integrated Surface Plasmon Resonance Technology to Investigate the Potential Targets and Mechanisms of Tripterygium wilfordii against Pulmonary Artery Hypertension TH MAK APP DAP PMC11653592__F5 Influence factors of CYPs and HSD17B in PH IGF1 COX2 HSD17B1 HSD17B2 AHR CYP1B1 PDE4B TNF CCND1 IGF2 PMC3875720__F4 Upregulated Genes Encode Key Enzymes in Central Carbon Metabolism.Steps in the glyoxylate cycle (A), gluconeogenesis (B), and oxidative pentose phosphate pathway (C) are shown tal-1 MGRA FBP1 PCK1 PMC3295664__F1 Methanol utilization (MUT) pathway in P AOX1 HEL-S-49 FBP1 PMC4112277__F1 The PPP and glycolysis is shown HEL107 HEL-S-133P PMC9610969__F2 Molecular Pathways Related to Sulforaphane as Adjuvant Treatment: A Nanomedicine Perspective in Breast Cancer BAX CCND1 CTNNB1 PMC3824052__F2 Smoking-Induced CXCL14 Expression in the Human Airway Epithelium Links Chronic Obstructive Pulmonary Disease to Lung Cancer ST14 JUP MUC13 CXCL14 PMC8779729__F1 Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential IREB2 KEAP1 GPX4 LPCAT3 HEL-S-102 FACL4 ALOX15 ATG5 PMC7813639__F2 Prospects for pharmacological targeting of pseudokinases RFWD2 TRIB2 FAM20C EPOR PI3 FRK FAM20A BRAF TRIB1 EPO GHR PMC7140895__F5 Expression of genes in biosynthesis pathway of catechins, theanine, and caffeine under N, P, and K starvation F3 AIDA PMC9482317__F2 TGFB signaling in the tumor metabolic microenvironment and targeted therapies SMAD2 SMAD4 MTOR SKP2 PMC12236007__F7 Hypothesis schematic models illustrates that Myh3 regulates the development of porcine intramuscular preadipocytes through the p38 MAPK signaling pathway to affect IMF content LPL CEBPA FAS HAL CDK2 PIGS PMC9482317__F3 TGFB signaling in the tumor metabolic microenvironment and targeted therapies HEL107 TGFB1 CD36 SMAD2 FASN TGFBR3 SREBF2 SLC7A5 PMC3275361__F3 Signaling and cross talk of the PTH and Wnt signaling pathways in osteocytes WNT3A DKK1 LRP5 LRP6 PTH AXIN2 PMC8977630__F3 Novel Synthetic and Natural Therapies for Traumatic Brain Injury AQP4 HMGB1 IGF1 APC BDNF MYD88 PMC6241212__F2 Innate antiviral immune responses during viral infection CSA2 MAVS STAT2 IRF9 TANK TLR9 TRAF3 TRAF6 IFNG STAT1 TLR3 USP18 TLR8 MX1 TLR7 ISG15 TYK2 PMC2646278__F5 Pathways of global genome nuclear excision repair (GG-NER) and transcription-coupled nuclear excision repair (TC-NER) XPA RBX1 CETN2 CDK7 CCNH XPC PMC4482723__F1 Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease TDO2 ID2 HEL-S-90n KMO ID1 IDO2 PMC9699386__F5 High Glucose-Induced Cardiomyocyte Damage Involves Interplay between Endothelin ET-1/ETA/ETB Receptor and mTOR Pathway BAX C2 MTOR FOS PMC8131923__F3 Adipose tissue plasticity and the pleiotropic roles of BMP signaling LOX BMP4 BMP2 BMP7 ATF2 PMC8131923__F4 Adipose tissue plasticity and the pleiotropic roles of BMP signaling BMPR2 SMAD1 DKFZp781O1323 PMC3163143__F2 Schematic presentation of molecular changes associated with N-Myc amplification in neuroblastoma MAX MYCL MDM2 MXI1 PMC8710790__F2 Cholesterol‐Associated Steatohepatitis in the Development of NASH ABCG8 ABCG5 NPC1 ACAT2 NPC1L1 ABCA1 PMC3163143__F3 Genomic and non-genomic actions of all-trans retinoic acid (ATRA) RAE1 APP ADAM10 SKP2 PMC8131923__F5 Adipose tissue plasticity and the pleiotropic roles of BMP signaling BMP4 ATF2 PMC7365923__F1 Artemisinin-family drugs for cytokine storm in COVID-19 IFNG CCL24 TIRAP STAT4 IL6 TRAF3 TRAF6 PMC3271661__F3 Summary of Kit/Kitl signaling during spermatogenesis BMP4 SOX3 BCL6B KIT DND1 FSHR DAZL PMC9270134__F6 Investigation of Molecular Mechanism of Banxia Xiexin Decoction in Colon Cancer via Network Pharmacology and In Vivo Studies PIK3CA CYP2E1 CCR5 CYCS GSK3B HIF1A MAPK8 CCL2 CXCL8 MAPK3 MAPK14 HEL-S-99n HMOX1 PRKCA MMP2 SRC MAPK1 CASP9 NOS2 CASP8 B2M VEGFA TNF FOS EDN1 RXRA EDNRB BCL2 HLA-B CXCR4 TGFB1 EGFR CCR3 PTEN MTOR INS COL1A1 HLA-G TLR4 CCND1 IL1B CDC2 BAX IL10 JUN RPS27A MMP9 PTGS2 RELA RS1 CASP3 NFKBIA NFE2L2 PMC3492913__F1 Diagrammatic representation of BMP signaling pathway BMPR2 SMAD1 DKFZp781O1323 BMPR1A PMC6270990__F2 PD-1 action on T-cells CD80 APC PMC338271__F1 HDL enhances NO production by eNOS in vascular endothelium APOB SRC PMC8484365__F2 Endocrine Disruption and Reproductive Disorders: Impacts on Sexually Dimorphic Neuroendocrine Pathways TF EGF EGFR ERG PMC3562404__F2 Biochemical relationships between the CDP-choline pathway of PtdCho synthesis, the degradation of PtdCho, and general phospholipid metabolism in mammals SMS CHDH PMC5964648__F3 UPRmt and stem cell regulation PHB2 ATF4 SIRT1 PMC7387468__F3 piRNAs related to the epigenetic control of pathways involved in vesicles transport, phagocytosis, demyelination, apoptosis, inflammation, loss of sensation, and pain are differentially expressed in leprosy patient (LP) KCNH1 GNAI3 ENTPD5 KCNK13 KNOP1 SHISA6 SLC9A2 TMEM59 GGCX IL21R TYRO3 ETV6 KCNQ2 DUSP8 CACNA1C CASP8 CARF TRPV1 CASP3 GNA11 SLC1A2 GLI4 IL23R SV2C CLVS2 PMC3319314__F3 APE1 role in DNA base excision repair (BER) FEN1 PCNA PMC6213852__F1 Host metabolism and cytokine induction TBK1 CGAS MAVS MFN2 IRF3 HIF1A MTOR MYD88 PMC8126031__F3 Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients STAT3 IGF1R ZEB2 MTOR IRS1 PMC11956735__F2 Platelet factor 4 (PF4) regulates several immune cells CXCR3 SYK IL13 APC TLR9 IL6 CCL5 TGFBR1 PDC TLR8 IL2 TLR7 PF4 PMC7265888__F2 Annotated KEGG pathway of Endocytosis (A), Peroxisome (B) and MAPK signaling pathways (C) about differentially expressed genes MLYCD EHD2 DBP HMGCL LOC51064 PEX19 CHL1 PEX6 NUDT19 PIPOX PEX2 PXMP4 PEX16 PEX10 PEX3 PEX12 DAO PEX26 PEX7 PTS PECR AMACR PHYH EPHX2 AMPH MPV17 MVK CROT PMVK GRB2 BIK MAX EGF FAS EGFR GIP PAOX NUDT7 BAAT KEL LDLR VPS36 PXMP2 AGPS JUN CD14 ddo DHRS4 XDH NLK TRAF2 PMC5986633__F7 Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death RHEB KLF15 TSC2 BCAT2 MTOR PMC6406952__F2 LncRNAs are mediators of angiogenesis and inflammation in EC STAT3 VEGFA TUG1 PMC7753952__F1 LKB1 in glucose metabolic reprogramming RHEB TSC2 TSC1 HDAC10 HEL-S-133P F2 HEL-S-162eP CRTC3 SIK2 ENO1 MTOR PMC9008213__F2 Two-Faced Role of Autophagy in Endometrial Cancer MTOR ULK4 PMC6389615__F1 Schematic representation of genes involved in osteoclast-poor and osteoclast-rich osteopetrosis RELA SNX10 PMC5597599__F13 Computational modeling framework MAPK14 EGF SOCS3 PMC11638062__F2 Examples of protein ubiquitination and their roles in ovarian cancer FBXO2 ARHGAP26 FBXO6 TRPM7 SOX6 RNASET2 HIF1A FBXO16 PMC11638062__F3 Examples of protein phosphorylation and their roles in ovarian cancer HEL164 EGFR PIK3R2 IRS4 PTEN MTOR PDK2 MYLK FER TRIM37 MYL2 SIK2 CDK2 FOXK2 PMC8495205__F1 Molecular Basis of Prostate Cancer and Natural Products as Potential Chemotherapeutic and Chemopreventive Agents FOXA1 NCOR2 CYP17A1 NCOR1 CYP11A1 PMC3690158__F1 Wnt signaling pathways RYK SRC CTNNB1 PMC6316648__F3 Major mechanisms for hepcidin regulation TF STAT3 SMAD1 TFR2 SMAD4 HAMP HFE2 ERFE BMP6 BMP2 HFE JAK1 TMPRSS6 PMC11823593__F2 Canonical and non‐canonical Wnt signaling pathway JUN APC LRP5 LRP6 RYK ARHA RHO CTNNB1 RSPO1 RNF43 DKK1 ZNRF3 GPR49 DAAM1 LGR6 PMC12086632__F2 The H2S–NO–HNO–TRPA1–CGRP pathway as a crucial element in migraine pathogenesis TRPA1 PMC11357267__F3 Pathways altered in chickens vaccinated with GII HEL-S-99n OS9 CANX EBP SEL1L BCL2 AMFR ATF4 EIF2A XBP1 VCP TRAF2 PMC7687681__F7 Indirect regulatory functions of miR-128-3p on FOXO4 NPTX1 FOXO4 SIRT1 PMC5983678__F1 GPCRs signaling pathway in HCC LPA HEL-S-11 RHO PMC10889780__F9 Putative roles of glutathione and AP-1 in the cooperation between VDDs and Nrf2 activators in inducing differentiation of AML cells NR1i1 KEAP1 RXRA MAF PMC6036887__F2 Butyrate suppresses colorectal cancer development BAX SP1 NRP1 PMC3763548__F8 Role of the eIF2A/ATF4 signaling pathway in the transcriptional activation of autophagy genes NBR1 ATG10 GABARAP DKFZp762B153 ATG3 ATG12 ATF4 GABARAPL2 EIF2A ATG5 PMC9606825__F2 NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia ADAM17 BCR NOTCH1 PMC4055861__F2 Base excision repair (BER) pathway OGG1 LIG1 MPG NEIL2 FEN1 NEIL3 NEIL1 UNG MBD4 TDG PMC11931723__F7 Genomic potential for tryptophan and indole-3-acetic acid (IAA) synthesis in Anza-Borrego isolates of Bradyrhizobium and Methylocaldum DEDD DDC PMC8530968__F2 Axon growth and innervation of peripheral targets ROR1 CD40 NGF TP53INP2 HGF ROR2 BDNF RAC1 PMC8261594__F5 Study on the mechanism of the Modified Ginseng-Schisandra Decoction (MGSD) in the treatment of recurrent respiratory tract infection (RRTI) based on network pharmacology MAX KL HEL-S-11 REL PMC12022909__F1 AhR-based drug discovery F3 AHR PMC8261594__F6 Study on the mechanism of the Modified Ginseng-Schisandra Decoction (MGSD) in the treatment of recurrent respiratory tract infection (RRTI) based on network pharmacology MAK CASP3 TNF PMC12022909__F2 Rewired Yonemitsu MCR: scope and mechanistic insights ATM PMC5338934__F1 Transport pathway of irinotecan.Notes: A prodrug, irinotecan, is moved into hepatic cells by passive effusion UGT1A1 CES2 CES1 APC ABCC2 ABCB1 PMC7886690__F1 Signaling pathways activated in the unfolded protein response (UPR) ELF2 ATF4 TRAF2 PMC7430846__F6 Signaling pathways associated with cold acclimation of two carp species activated in the FoxO signaling pathway CD36 EGFR BNIP3 PTEN IGF1R PDK2 INS IGF1 HMGCR INSR CCNG2 GRB2 SIRT1 PMC7353687__F4 Signal pathways and metabolic pathways involved in abnormal RBP HOXD10 CD44 STAT3 STARD13 PTEN HOXD1 MYC PMC9515729__F2 Beneficial Role of Vitamin D on Endothelial Progenitor Cells (EPCs) in Cardiovascular Diseases NR1i1 IL6 VCAM1 PMC4038461__F6 Finding Novel Molecular Connections between Developmental Processes and Disease HIF1A MTOR SRC PMC3340185__F5 A model for the XIAP-regulated RhoGDI SUMOylation signaling pathway in modulation of cell motility UBC ARHA OTP PMC8272721__F6 Proposed model of selective anticancer activity of NSLC01 in cancer cells with high NRF2 activation EEF2K PHGDH EEF2 PSAT1 ASNS PSPH PMC7472841__F3 RIG-I-like receptors (RLRs) antiviral signaling pathway TBK1 MAVS IRF3 IRF7 TRAF3 TRAF6 TRAF2 PMC8955204__F1 MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging RPTOR PSMD3 IGF1 MFN2 MTOR TRIM63 PMC3203691__F3 CXCL10/IP-10 in Infectious Diseases Pathogenesis and Potential Therapeutic Implications CXCL9 IFNG PMC138693__F2 Phosphoinositide 3-kinase (PI3K) signalling and cancer BRCA1 ATM PTEN PMC4502956__F1 TRAIL signaling pathway BAX CASP9 CASP8 CASP6 MCL1 CASP3 BCL2 APAF1 FADD PMC3095770__F2 Hypothalamic proopiomelanocortin processing and the regulation of energy balance STAT3 PRCP POMC PCSK2 NHLH2 PMC4502956__F2 TRAIL signaling pathway and some points of therapeutic intervention MCL1 BCL2 PMC11918095__F7 SiO influences fibrosis in HTMCs via ferroptosis induction GPX4 SLC7A11 NOX4 PMC9283766__F2 Insights Into the Role of Platelet-Derived Growth Factors: Implications for Parkinson’s Disease Pathogenesis and Treatment TH JUN CTNNB1 PMC11907553__F1 The KRAS signaling pathway CDC42 TBK1 BAD MTOR KRAS PMC10418793__F6 Major pathways involved in retinal inflammation STAT3 JUN RELB MTOR FOS PMC3270265__F5 Regulation of cell death by glucose metabolism BAD MTOR FADD PMC11212664__F8 Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DSS-induced colitis NOD2 NOD1 MYD88 PMC3270265__F3 Glucose metabolism in cancer cells F2 HEL-S-162eP ENO1 TIGAR PMC9102069__F2 Immunogenic Cell Death, DAMPs and Prothymosin A as a Putative Anticancer Immune Response Biomarker BAX MLKL PMC8402745__F4 Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges SOCS1 STAT3 STAT1 ARID5A SOCS3 PMC6400555__F3 Models for the roles of Scribble in organizing molecular interactomes involved in synaptogenesis, epithelial polarity, and adhesion, and growth regulation LATS1 LATS2 DLG5 FAT1 SCRIB RHO PMC11974557__F1 Adipose Tissue Inflammation and Insulin Resistance Mediated by TLR4 Activation and Adipokines CRP IRS1 PMC8402745__F2 Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges TMPRSS2 DPP4 ACE2 PMC8402745__F3 Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges HMGB1 NLRP3 MASP2 TLR4 MYD88 PMC10216084__F8 TRPV4 and TRPM8 signalling pathways relevant to the present study C6 TRPC6 TRPC3 TRPM8 PMC2391280__F1 A signaling pathway AKTing up in schizophrenia DRD1 DRD2 PMC3216694__F1 Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors LPA PC HEL-S-11 RHO LPP PMC7212589__F8 Mechanistic working model of EVI5 in controlling Emi1 accumulation or TGF- B/Smad signaling pathway: MiR-486-5p regulates EVI5 expression via Emi1 or TGFB/Smad signaling in NSCLC CDH2 APC MMP2 CCNA2 PMC7997242__F4 CD226 downregulation CD226 SRC PMC4923112__F3 Classification pathway for primary lymphedema GATA2 VEGFC KIF11 FH FOXC2 CCBE1 FLT4 CXNO MTOR PMC1952166__F1 Signaling cascades required for TCR-mediated integrin activation CDC42 PLCG1 LAT ITK PMC6059364__F2 Crosstalk of Notch with p53 and p63 in cancer growth control KLF4 BAD GADD45B PTEN SCO2 MDM2 BCL6 PMC4856261__F6 NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes CD40 ZAP70 EGF TRADD TNFAIP3 TIRAP CARD11 TAB3 MYD88 HDAC1 UBE2V1 NGF MAP3K7IP1 PLCG2 HDAC2 LCK FADD PMC4856261__F4 NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes SOCS1 BAX IFITM2 STAT2 PSMB8 IFITM1 IRF1 TAP1 IFNG STAT1 IFITM3 BCL2 JAK1 OAS1 TYK2 PMC3084988__F2 TLR structure and signaling TLR3 TIRAP IRF3 PMC4856261__F5 NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes TRIM25 RIPK1 TRAF3 TRAF6 TRAF2 FADD PMC9619213__F2 Follistatin-like protein 3 in human non-tumor pathophysiologies and cancers FSTL3 CD36 SMAD2 MMP2 ADAM12 MMP9 SIRT1 YAP1 IL1B CTNNB1 PMC7955704__F2 EGFRex20ins TKI resistance CDK6 ERBB4 EGFR PMC7608616__F3 Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance BAX GSK3B PTEN PMC11203611__F4 Diagram of endocannabinoid biosynthesis and mode of action of the endocannabinoid system within a neuron NAPEPLD TRPV1 FAAH PMC5599995__F6 Proposed model by which mesenchymal stromal cell (MSC) derived soluble PD‐1 ligands modulate the activation status and effector function of CD4+ T cells PTEN PMC5027689__F1 Fanconi anemia (FA) DNA damage repair pathway ATR ATRIP PMS2 BRCA2 CLK2 POLI FANCM FANCL FANCA BLM FANCC UBE2T FANCB FANCE FANCG FANCD2 FANCF POLK EME2 FAAP24 POLN SLX4 EME1 PMC6747410__F1 Signaling pathway of DNAM-1 receptor FYN PLCG2 VAV1 PMC3023986__F2 Wnt Signaling as a Therapeutic Target for Bone Diseases DKK1 APC ROR2 LRP5 LRP6 RYK SRC TEF LEF1 SFRP1 CTNNB1 PMC9377071__F7 Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease RIPK3 MLKL RIPK1 PMC3422444__F1 AIDing antibody diversity by error-prone mismatch repair MSH6 MSH2 PCNA PMC3422444__F2 AIDing antibody diversity by error-prone mismatch repair MSH6 MSH2 PMS2 H2AX RNF8 PMC3923659__F3 Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer IL10 MAPKAPK2 TAB3 IRAK1 IRAK2 IRF7 TRAF6 IRAK4 MYD88 IL1R1 MAP3K7IP1 MBP IL1B PMC5076853__F1 More to life than NFKB in TNFR1 signaling SHARPIN TRADD TAB3 RIPK1 TNF TRAF2 PMC5749242__F5 The two fates of C3b generated in the retina HEL-S-62p CFI CFD CFH PMC11056704__F8 Graphic illustration for role of oestrogen‐induced exosomal SNHG17‐CCL13‐CCR2‐M2 macrophage axis in ovarian cancer CCL13 CCR2 PMC3923659__F2 Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer MAPKAPK2 TAB3 IRAK1 IRAK2 IRF7 IL1A IL6 TRAF6 IRAK4 MYD88 IFNG IL1R1 MAP3K7IP1 COX2 MBP CCND1 IL1B PMC6617682__F1 The mechanism of exosomal miRNAs loading DGCR8 AGO2 DROSHA PMC4937511__F9 Candidate SCI biomarker input for Systems Biology and pathway network analysis GOT2 HEL-S-49 ANXA2 FASN EEF2 ANXA1 PMC3405917__F4 EMT in fibrosis CDH2 ZEB2 PMC9412305__F4 The Innate Immune Response during the Human Papillomavirus Life Cycle BAX FAS PMC9412305__F5 The Innate Immune Response during the Human Papillomavirus Life Cycle BAX TBK1 CGAS MAVS IRF3 PMC7085234__F1 RREB1-involved in MAPK signaling pathway RREB1 EGFR GRB2 PMC7085234__F2 RREB1 regulates different target genes in different cancers RREB1 ANKRD1 ANGPTL4 ARHGEF2 PMC3722486__F9 Proposed role of Foxg1 in CM development FOXD1 MSX1 OTX1 PAX6 CCND1 LEF1 WNT2B FOXG1 PMC4524513__F1 Tendon Mechanobiology: Current Knowledge and Future Research Opportunities COMP tmp_locus_29 AIP OTP PMC3405917__F1 Wound repair and fibrosis IL25 TSLP TGFB1 IL33 TNF PMC6841741__F3 Ingenuity pathway analysis of the significantly altered miRNA found in the follicular fluid showing that 12 of these miRNA were related to the genes involved in the Inflammatory disease pathway JUN CSF2 PSPN TNF MAP2K4 HPS4 GPR75 MAF RAM2 GPR180 GPR135 NCL LMNA PMC5725281__F9 Cardioprotective effect of CAPE-oNO2 BAX SMAD2 NRF1 SIRT1 HEL-S-44 PMC7052362__F2 Tumor-associated macrophages (TAMs) in promoting tumor progression and related mechanisms STAT3 CD24 ELMO1 APOE SIRPA SIGLEC10 LILRB1 CD47 PMC6384614__F5 Biosynthetic pathway for the capuramycin-type nucleoside antibiotics APP HEL-S-66 LIPK PMC6841741__F2 Ingenuity pathway analysis of the significantly altered miRNA found in the follicular fluid showing that 12 of these miRNA were related to the genes involved in the Organismal Injury and Abnormalities, Reproductive System Disease pathway CRACR2B MT1A PGC DNAH7 KANK3 GPR75 SHE SLC22A10 SP5 SELENOW PMC9553103__F2 ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain PNP AK1 ENPP1 ADA PMC9055718__F6 Anti-inflammatory effects of lavender and eucalyptus essential oils on the in vitro cell culture model of bladder pain syndrome using T24 cells LTA IRF3 IL1B PMC5931372__F1 Clonal evolution mechanisms in NT5C2 mutant relapsed acute lymphoblastic leukemia TPMT PMC8632384__F11 Network Pharmacology-Based Study on Irritable Bowel Syndrome Prevention and Treatment Utilizing Shenling Baizhu Powder JUN SELE UMPS TNF PMC7576987__F5 Working model of 2,3-DCPE in colon cancer cells ATR ATM PMC6006682__F4 Representative coverage of Calvin-Benson cycle enzyme HEL-S-68p HEL-S-162eP FBP1 PMC8324677__F1 Stress kinases in the development of liver steatosis and hepatocellular carcinoma BAX ACOX1 EHHADH NR1C1 FABP5 NCOR1 FGF21 RAC1 IRS1 PMC4237616__F2 Survival tree analysis of significant SNPs associated with NSCLC survival identified from the single SNP analysis (q<0.10) in our initial cohort WNT5B CXXC4 AXIN2 WIF1 PMC8949960__F1 Cancer-Related Cachexia: The Vicious Circle between Inflammatory Cytokines, Skeletal Muscle, Lipid Metabolism and the Possible Role of Physical Training RICTOR ALK IGF1 SMAD2 IGF1R IL6 MTOR PMC8949960__F2 Cancer-Related Cachexia: The Vicious Circle between Inflammatory Cytokines, Skeletal Muscle, Lipid Metabolism and the Possible Role of Physical Training ALK IGF1 SMAD2 IGF1R IL6 MTOR PMC4965740__F9 Computational discovery of Epstein-Barr virus targeted human genes and signalling pathways SMAD1 HHIP CDON DYRK1A BOC KIF27 CTNNB1 CDK8 MED12 SHH SMO GAS1 HEL2 MED23 NR2E1 SIN3A ARRB2 MED6 DHH IHH MED1 SKI KIF7 SAP18 PTCH2 SUFU PTCH1 CREBBP SDC2 GLI3 PMC3080795__F2 Scheme for CCM including main pathways - glycolysis/gluconeogenesis, penthaphosphate pathway, citrate cycle, overflow pathway RPIA MAL SUCO CIT PMC7460634__F2 Semaphorins in adipogenesis SEMA3A SEMA3G GSK3B PMC4965740__F8 Computational discovery of Epstein-Barr virus targeted human genes and signalling pathways WDR12 STAT3 SMAD1 DTX1 HEY2 ITCH PIK3R2 GSK3B PIK3R1 NUMB YY1 PSEN1 SKP2 FBXW7 MAML3 ASCL1 JAG2 APP FHL1 NOTCH3 DLL3 HDAC2 MAML2 HES1 NOTCH1 HES5 SPEN SIN3A BLOC1S1 DLL4 MAGEA1 HES6 CNTN1 NOTCH2 RBPJ SAP30 TCF3 NFKB1 PSEN2 EP300 SNW1 LEF1 LCK PMC8380049__F2 Novel Experimental Therapies for Treatment of Pulmonary Arterial Hypertension BMP10 BMPR2 SMAD1 DKFZp781O1323 SMAD4 PMC6637138__F7 Innate immune response activation in BRCA2-deficient cells STAT1 CGAS STAT2 IFNAR2 BRCA2 IFNAR1 IRF3 PMC4264220__F1 Schematic representation of homocysteine metabolism and intersection with glutathione (GSH) production and folate cycle PMC3309495__F2 Pathway analysis of altered metabolites upon paroxetine treatment GYS2 DPP4 GCK HEL-117 PMC4155643__F1 Pathways of sphingolipid degradation and synthesis ELOVL2 HACD1 ACSL3 ACER1 SPHK1 FACL4 ELOVL1 ELOVL5 CERS6 ELOVL4 ASAH2 ELOVL3 SPHK2 CERS3 CERS5 ACSL6 ACSL5 CERS1 CERS2 HACD3 HACD2 HACD4 ALDH3A2 ACSL1 ELOVL6 ACER3 PMC7348939__F1 Fundamental aging mechanisms that contribute to sarcopenia OPA1 MFN1 MFN2 PMC7348939__F2 Possible molecular mechanisms of cellular senescence in skeletal muscle cells CYR61 WNT3A CDK2 CDK4 PMC6028526__F2 Insulin biosynthesis and secretion PDX1 NEUROD1 MAFA INS SST PMC3943598__F1 Molecular mechanisms in Carney complex (CNC) and McCune-Albright syndrome (MAS): Receptor activation (ligand binding) makes GsA to exchange GDP to GTP, GsA is then freed from the BetaG dimer and activates adenyl cyclase (AC) GNAS CTNNB1 PMC3056800__F7 Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds ASL GC AIDA GDA PMC3639322__F3A Time-dependent network analysis reveals molecular targets underlying the development of diet-induced obesity and non-alcoholic steatohepatitis PPARG ACACB NR1C1 CRAT LEP HEL-S-273 ITCH CIDEC FABP4 MGLL GCK GBP2 PMC3681733__F2 Reprogramming Neutral Lipid Metabolism in Mouse Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes LPA LIPA MGAT1 DGAT1 ABHD5 MGAT2 LIPE PC PLD3 PMC3257556__F2 Known components of the PCP signalling pathway and related cellular functions CDC42 FAT4 PRICKLE2 DVL1 FRZB INTU CELSR1 PTK7 DVL2 ARHA RAC1 FUZ FZD3 VANGL1 RHOB ROCK1 PMC5813884__F5 Nitrogen regulation of the GAAC pathway ELF2 EIF2A CDC34 PMC5813884__F6 Influence of the RTG pathway on nitrogen metabolism MKS1 HEL60 HEL-S-26 PMC2813229__F4 Pathway analysis result showing 18 differentially expressed proteins following 50% PH can be sorted into the c-myc pathway PROX1 PML NDUFS3 ACADM PMC6151665__F8 Mechanism of emodin to inhibit IAV replication and IAV viral pneumonia TLR4 NQO1 GCLC TRAF6 PMC5088520__F1 Path2enet: generation of human pathway-derived networks in an expression specific context DVL1 DTX1 DTX2 DTX3 DTX4 NUMB PSEN1 PSENEN CTBP2 MAML3 CTBP1 JAG2 LFNG DLL3 MAML2 HES1 HES5 DLL4 DTX3L DVL2 RBPJL NCOR2 MAML1 PSEN2 DVL3 CREBBP SNW1 KAT2B PMC5088520__F2 Pathway-expression-networks produced for B cell CD19+ (top), T cell CD8+ (bottom left) and T cell CD4+ (bottom right) based on the transformation of the NOTCH Signaling Pathway done with Path2enet DVL1 CTBP2 DTX3L NUMB DVL3 LFNG CD19 EP300 MFNG PMC8835043__F1 Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin CDC2 CDK2 CDK4 PMC1371031__F4 Model on Bcr effects on Beta-catenin BCR GSK3B MYC CTNNB1 PMC6509867__F8 Annotated functions of the extracted pathway network TUNAR GAL LAT EGFR GNAL HEL-S-11 PMC6948307__F5 Schematic diagram of IL-1B signaling pathway in MSC adhesion to HUVECs IL16 MSC PMC3210925__F5A Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis PGP HPR PMC6635885__F2 Activation modes of the NLRP3 inflammasome and the regulatory mechanism of CVDs CASR RYR2 NLRP3 TXNIP TLR4 IL18 IL1B PMC2683106__F5 Promoting cell proliferation and repressing differentiation EBF2 CCNG2 SOX2 MTOR MIXL1 PITX2 PMC6368065__F7 Hematopoietic deletion of COX-2 increases adiposity and AT inflammation in obesity FZD4 MMP12 COX2 AXIN1 DVL3 FABP4 PMC6220476__F1 Circular RNA ITCH and 0043256 act as miRNA sponges to regulate the expression of ITCH ITCH CTNNB1 PMC8269088__F1 Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets STAT3 SYK MAL IRAK1 BLNK TLR5 IRF3 IRAK2 MTOR TRAF3 TRAF6 IRAK4 MYD88 TLR1 BTK FYN BCR LYN GRB2 PMC8269088__F2 Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets FBXW7 CCL19 DLL4 DLL3 PMC7555769__F2 Noncanonical HH signaling pathway SMO ARHA RHO MTOR PMC6117282__F2 Gene networks involved in a) 'developmental disorder, ophthalmic disease, organismal injury and abnormalities' (score = 41) and b) 'cell-to-cell signaling and interaction, nervous system development and function, inflammatory disease' (score = 21) VDAC3 RYR3 IFNG APH1B APP UNK FAM210B JUN GPR119 RAC1 FOS UNKL VPS35 DDX24 IPP TIGD1 TMED8 FOXO1 NBPF10 SPATA16 PLPP5 CASP3 CFHR2 SNTB2 CMTM2 PMC7555769__F3 SMO in cancer BMP4 MMP2 BCL2 SMO CCNI RHO MMP9 PMC4496218__F9 Pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis PTEN VCAM1 PMC11731776__F2 Figure compares normal and G3BP1-depleted or inhibited senescent cells STAT3 IRF3 PMC7555769__F1 Canonical Hedgehog (HH) signaling pathway FOXF1 SUFU BCL2 SMO CD133 PMC3535180__F1 Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target? CRP COX1 IL1B PMC11731776__F3 Figure illustrates the DNA damage response pathway leading to cellular senescence ATR CDK6 CDK2 ATM GATA4 CCND1 CDK4 PMC6058063__F1 Immunoglobulin G4-related disease (IgG4-RD) and immune pathways to therapy. Naïve B cells are activated by exposure to antigens IL-21 CD40 CD80 IL10 BCR CD27 IL21R CD19 PMC8882273__F7 Selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease NLRP3 IL1B HTT PMC5542228__F5 Quantitative proteomics profiling reveals activation of mTOR pathway in trastuzumab resistance RPS6 RPTOR PIK3CA EIF4B CAB39 EIF4EBP1 RPS6KB2 RPS6KA1 RPS6KA4 MTOR MLST8 RICTOR PDPK1 RPS6KB1 PRKAA2 RPS6KA3 PMC9324353__F2 Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90 BAX FAS EGFR BCL2 MTOR HEL-S-100n CDK4 FADD PMC12146343__F2 Signals from the gut microbiota lead to the differentiation of T cells into various subtypes TGFA TLR4 FOXP3 MTOR GATA3 MYD88 PMC12146343__F1 Gut microbiota involved in the development of AIH TLR4 AHR MTOR PMC6605322__F7 Scheme summarizing the protective effects of sevoflurane on lipopolysaccharide-induced inflammation and apoptosis by suppressing the activation of the miR-27a/TLR4/MyD88/NFKB signaling pathway TLR4 MYD88 PMC8579454__F3 Lipid-induced S-palmitoylation as a Vital Regulator of Cell Signaling and Disease Development ZDHHC6 FYN CD36 TLR4 FASN LYN IL8RB TNF IRAK4 MYD88 PMC4127586__F2 A model of Src homology 2B1 regulation of leptin signaling STAT3 SH2B1 IRS1 PMC6692341__F5 Control of fruit biochemical composition CD2 CCS HEL-S-5 CER1 ACER3 PMC4699913__F4 Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling WRNIP1 CDC2 BAX ATR SPR TIMELESS PCNA PML SMC1A MTOR NCOA1 XPC KIF23 MAPK14 FANCD2 CHD4 NONO PIAS1 CHEK2 ATM RNF20 INTS3 RAX PMC6192992__F6 Scheme depicting role of HORMAD1 in DSB signaling and repair BRCA1 RNF8 ATM PMC9711961__F8 Paeoniflorin Inhibits LPS-Induced Activation of Splenic CD4+ T Lymphocytes and Relieves Pathological Symptoms in MRL/lpr Mice by Suppressing IRAK1 Signaling TLR4 IRAK1 TNF PMC6764628__F5 Relationships of the top differentially expressed genes within the top GSEA gene sets RRAD ADM GEM MCL1 PTGS2 IL6 HMOX1 ATF3 BTG2 HEL-S-102 GADD45B EGR2 TM4SF1 PMC9693644__F1 Epha2 Receptor Blockers Involved in Cerebral Malaria from Taraxacum officinale, Tinospora cordifolia, Rosmarinus officinalis and Ocimum basilicum: A Computational Approach LTA EPHA2 CCL2 TNF UNK PMC5426657__F7 Protective effects and functional mechanisms of Lactobacillus gasseri SBT2055 against oxidative stress HMOX1 NQO1 GCLC PMC11392660__F3 Immunologic mechanisms following decellularized matrix transplantation involve several crucial steps TLR9 PTEN MTOR MYD88 PMC2989646__F4 The involvement of zinc metalloproteinases in AB metabolism IDE ADAM19 ADAM17 ADAM9 ECE1 ADAM15 APP ADAM33 ADAM10 ADAM8 PMC8367322__F1 LncRNA BANCR in Human Cancers: An Updated Review APC GSK3B CCND1 CTNNB1 PMC6186432__F2 Apoptotic membrane blebbing through DR5/Casp-3/ROCK1 signaling pathway MYLK LIMK2 FADD PMC7642512__F2 CD40 induces activation of autophagy signaling pathway CD40 ATG3 ATG16L1 ATG12 ULK1 MTOR ATG5 UNK PMC8367322__F4 LncRNA BANCR in Human Cancers: An Updated Review CDH2 SOS1 ARHA GRB2 TNF PMC8349595__F4 Nutrition, One-Carbon Metabolism and Arsenic Methylation GAA AS3MT HEL-S-20 PEMT PC HEL-S-61p SLC19A1 MTR PMC11817496__F9 The apoptosis signaling pathway triggered by PM2 BAX CASP9 CASP8 TRADD CASP3 AIP PAH CASP10 TRAF2 FADD PMC3096731__F1 Eph receptor and mTOR pathway crosstalk: implications for cancer RHEB TSC2 TSC1 PTEN MTOR PMC4240271__F1 Post-translational regulation of TGFB receptor and Smad signaling PPIE ROCK2 ITCH SMAD4 TRAF6 SKI WWP1 BAMBI CD44 HGS SMURF1 USP15 SMURF2 STRAP PMC6075432__F14 Sodium fluoride induces autophagy in mammalian mice spleen ATG16L1 ATG12 MTOR ATG5 PMC9404585__F1 Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2 SYK TYROBP MTOR SRC PMC6803322__F8 Diagram illustrating the IL-6 signaling pathway triggered by the binding of IL-6 and its receptor complex resulting in JAK2/STAT3 activation STAT3 SOCS3 PMC7010923__F2 Proposed model for signaling pathway of fibrosis in MDC1A HEL-S-28 MTOR ACE2 PMC9469193__F8 Antigastric Cancer Effect of Triptolide is Associated With H19/NFKB/FLIP Axis TRADD TNF PMC7822116__F3 Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects? SIRT3 PON1 GPX1 HEL-S-44 PMC5945496__F6 Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells HRAS HMOX1 TXN KEAP1 GCLM BRAF ABCC3 SFN SLC7A11 PMC12136072__F2 Signaling pathway of BMP4 as well as activators and inhibitors of BMP4 cellular signaling BAMBI BMP1 SMURF1 SMAD6 SMAD4 SMURF2 PMC12136072__F3 Recent Advances in the Delivery of Bone Morphogenetic Proteins for Targeting Glioma: An Updated Review BMI1 STAT3 SMAD1 DKFZp781O1323 TNFAIP3 PTCH1 SHH SMO NOTCH2 NOTCH3 NOTCH1 GLI3 PMC8536203__F9 Proteomic Landscape of Extracellular Vesicles for Diffuse Large B-Cell Lymphoma Subtyping CD79B SYK CD79A RAF1 SOS1 CD72 RASGRP3 CARD11 GSK3B CD22 PPP3CA IKBKG PRKCB BTK PLCG2 GC CHUK CD81 FCGR2B IFITM1 BLNK PIK3AP1 CD19 VAV1 PTPN6 FOS DAPP1 HRAS LILRB2 IKBKB HP LYN MAP2K1 GRB2 NFKBIB PMC5468628__F1 GRN and SBN circuits HESX1 VIP SIX6 SOX2 FOXG1 GBX2 PROX1 LMO4 SIX3 BMP4 OTX2 SOX3 EN1 SHH WNT1 WNT8B FEZ1 AVP PMC3649098__F3 Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis CRP TF COX2 IL16 VCAM1 PMC8520942__F1 Recent Advances of WEE1 Inhibitors and Statins in Cancers With p53 Mutations CDC2 GPX4 MVP WEE1 CDK2 PMC5710670__F1 Clinically relevant inhibitors of the isoprenoid biosynthetic pathway (IBP) (a) Statins inhibit HMG CoA reductase, consequently reducing the entire IBP CDC42 IPP RAP1A FDPS ARHA RAC1 PMC5987911__F1 Logical regulatory network graphs for a mammalian cell cycle network (PN1) and a melanoma-related pathway network (PN2), modified from and 1 in Qian and Dougherty, respectively HADHB CDC20 STC2 S100P PMC9319949__F11 Repositioning Linagliptin for the Mitigation of Cadmium-Induced Testicular Dysfunction in Rats: Targeting HMGB1/TLR4/NLRP3 Axis and Autophagy BAX HMGB1 NLRP3 TLR4 DPP4 BCL2 SQSTM1 MTOR PMC5854428__F1 Viral manipulation of STAT3: Evade, exploit, and injure STAT3 EGFR JAK3 PTPRC IL21R IL7R PTPRT MTOR SOCS3 DUSP2 CNTFR TRIM28 OSMR JAK1 SRC TYK2 GHR PMC5854428__F2 Viral manipulation of STAT3: Evade, exploit, and injure STAT3 TRIM28 PC SOCS3 JAK1 PMC2957472__F3 Helicobacter pylori: gastric cancer and beyond APC GSK3B LRP5 LRP6 CTNNB1 PMC12110123__F9 Ginsenoside CK can enhance the expression of CD69, CD80, and CD86, stimulate the NFKB and AP-1 inflammatory signaling pathway, and induce macrophages to secrete iNOS and TNFA to enhance inflammatory response CD80 CD69 CD82 PMC4715579__F6 Top biological network generated by Ingenuity Pathway Analysis for differentially expressed proteins of (A) ALDH+/CD44+CD24−, (B) ALDH+/CD49f-EpCAM+ and (C) CD44+CD24−/CD49f-EpCAM+ PDCD11 FUS LONP1 ATXN10 SF3B1 COPS5 CCT4 NUMA1 PLAA STAU1 PROX1 HSPD1 YBX3 WTAP SNRPB CSNK1A1 NF2 TARDBP RPLP0 NAMPT GLO1 TUBB ANXA11 CAPNS1 RUVBL2 PMC6042724__F3 Whole exome sequencing identifies MRVI1 as a susceptibility gene for moyamoya syndrome in neurofibromatosis type 1 HRAS RGS2 ENG MTDH NF1 TRPC4 SFN TGFBR1 PMC12110123__F5 Anticancer Mechanisms of Ginsenoside Compound K: A Review MMP2 MMP9 CXCR4 PMC4397421__F1 Translocations affecting the NFKB activation pathway CSA2 BCL10 CARD11 PTS TRAF6 BIRC2 MYD88 PMC12110123__F4 Ginsenoside CK inhibits the expression of AKT/mTOR/p70S6K1 proteins and blocks the PI3K/AKT/mTOR signaling pathway in cancer cells, reducing the expression of MMP2 and MMP9 proteases MMP2 MMP9 MTOR PMC6476865__F2 The PI3K-Akt-mTOR signaling by bioactive sphingolipids RHEB S1PR1 S1PR3 CERK S1PR2 PMC3011892__F4 Cell cycle pathway containing Treponema denticola differentially regulated genes in calvarial bone compared with sham-infected controls at P ≤ 0.05, adapted from Pathway Express and using the Kyoto Encyclopedia of Genes and Genomes nomenclature CDK7 PCNA CDK2 MYT1 PMC5182153__F1 Insulin Receptor Signaling Pathway Targeted by Surgery-Responsive microRNAs ACLY BAD VAMP2 ELL PTEN MTOR SOCS3 EIF4E CRK PDE3B CBL TSC1 GRB10 FYN INSR LIPE STX4A GRB2 PMC3011892__F5 Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles CDK7 MALL PCNA CDK2 ORC2 PMC9692683__F2 SARS-CoV-2-Induced Amyloidgenesis: Not One, but Three Hypotheses for Cerebral COVID-19 Outcomes CRP GFAP NLRP3 S100B PMC3011892__F1 Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles SPN CD226 CD40 ICOS CD80 CD2 APC CD22 PTPRC CTLA4 CD6 PMC5567867__F1 Major steps in the HR pathway in budding yeast RAD52 ATR RAD51 PMC3163259__F1 Wnt/Beta-catenin signalling in the absence and presence of Wnt stimulus DKK4 DKK3 DKK1 GSK3B NLK DKK2 CTNNB1 PMC7705761__F4 Identification of key gene networks controlling organic acid and sugar metabolism during watermelon fruit development by integrating metabolic phenotypes and gene expression profiles DAP CS PMC5910271__F2 Redox Regulation of Circadian Molecular Clock in Chronic Airway Diseases SIRT3 SIRT1 PMC8657568__F1 Plant Dehydrins: Expression, Regulatory Networks, and Protective Roles in Plants Challenged by Abiotic Stress ICE1 MAPK6 PMC8043250__F1 Top left, in red: NK cells recognize tumor targets that lack MHC, as this prevents the inhibitory response mediated by KIR CD96 CD226 TIGIT CDS2 CRTAM PLCG2 EGFR VAV1 MICA MICB PMC3747619__F2 Key reactions involved in the sphingolipid metabolic pathway UGCG CERK KDSR PMC9655901__F3 Interplay between Autophagy and Herpes Simplex Virus Type 1: ICP34.5, One of the Main Actors TBK1 CGAS MAVS PCNA KEAP1 IRF3 C1QBP PMC6321280__F3 Many molecules regulate apoptosis and Hippo-YAP signaling pathway S100A1 RASSF6 FBXW7 EGR1 ITCH CRB3 IKBKE PML TFAP2C AJUBA ARHA PMC5080657__F2 Genetics of immune-mediated disorders FGFBP2 OCC1 UBE2L6 KLF6 PSTPIP2 MYADM S100A10 TAP1 CCL5 GBP1 FOS CRIP1 GBP4 STAT1 GZMH NLRP12 TAGAP RIPK2 PPP1R15A SH2B3 GBP2 PMC2763943__F2 Nox proteins in signal transduction TRADD PAK1 MAPKAPK2 PMC4694912__F3 MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model MSH6 PCNA RPA3 ESCO1 SMC3 DERPC ATM CHTF18 CS INS RPA1 PMC7082279__F1 Resistant mechanisms of TKIs in target therapies of NSCLC EGFR IGFBP1 SDC4 IGFBP4 TFG IGF1R KRAS EML4 NRG1 ALK CD74 ERBB2 LAT2 PMC6321280__F1 Components of the Hippo-YAP signaling pathway LATS1 LATS2 PMC9158463__F1 Understanding How Physical Exercise Improves Alzheimer’s Disease: Cholinergic and Monoaminergic Systems GSK3B APP ARHA SIRT1 PMC7029504__F7 FOXO signaling pathway enriched in KEGG STAT3 KLF2 SMAD4 BNIP3 PTEN INS SKP2 ATG12 INSR CDK2 ATM NLK MDM2 PMC7484684__F5 DE miRNA/mRNA interaction network constructed and visualized using Cytoscape software MYO1D COQ2 LRTM2 NR1C2 SPPL3 ST6GALNAC6 RAB22A MIPOL1 STRN3 PRKCB KRTAP7-1 SLAMF7 MFAP3L LRFN2 ADD1 SLC7A6OS HIPK2 KIFC2 AEBP2 SMAP2 MEGF9 PRKCA TRIM31 SLC22A3 LRP6 SFRP1 CHI3L1 TANC2 N4BP1 CFTR CPNE2 RBKS SDC3 PMC4050496__F2 Notch: Architect, Landscaper, and Guardian of the Intestine EGF FURIN PMC3835661__F1 Cell Death in Heart Disease TRADD TRAF2 FADD PMC8263688__F8 IL-17 signaling pathway plays a key role in laryngeal squamous cell carcinoma with ethnic specificity JUND TRADD TNFAIP3 MAPK13 TAB3 GSK3B TRAF3 MAPK8 TRAF6 CXCL8 CXCL3 MAPK3 IFNG CCL7 IL18 ANAPC5 CHUK MMP3 CEBPB IL17F IL17RC CSF2 CASP8 CCL11 MMP9 TNF HEL-S-125m ELAVL1 NFKB1 MAPK7 NFKBIA MAP3K7 PMC7458396__F2 Cellular signalling pathways mediated by the constitutive activation of US28 STAT3 HEL-S-162eP RHO JAK1 CCND1 CTNNB1 PMC4100111__F3 Bioinformatics analysis by String KRT18 OXTR HEL-S-97n VCP PGAM1 CPA2 HEL-S-304 HEL-S-125m HEL-S-68p CPB1 CTRB1 MYG1 NPLOC4 DNPEP UBXN6 PMC3546894__F1 Cytokine regulation of immune response cell phases through gender specific pathways IFNG IL10 IL6 PMC5152733__F1 Lymph node fibroblastic reticular cells in health and disease PDPN CLEC1B LTBR CCL19 MFGE8 CXCL13 MADCAM1 CCL21 NFKB2 CXCR5 VCAM1 CXCR4 PMC5963715__F3 PI3K/AKT/mTOR signaling pathway RHEB TSC2 PTEN MTOR PMC5352059__F4 Differentiated regulation of immune-response related genes between LUAD and LUSC subtypes of lung cancers GRAP2 CD40 CD80 PIK3CA TIRAP VAV2 LAT CARD11 DAO MYD88 IFNG LY96 SOST FYN CDA BCL10 IL18 RIPK1 IL2 CDK4 IL10 CSF2 LCP2 NCK1 MAL CTSK CD14 IL4 CTLA4 IL6 ARHA PTPN6 FOS ICOS PAK1 NFKB1 GRB2 CD3G LBP CD3E LCK PMC9099959__F4 Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology ATR BRCA1 ATM AHR PMC9099959__F5 Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology HEL-S-71 TRADD TAB3 IRAK1 AHR IRF7 TLR7 TRAF6 TRAF2 IRAK4 MYD88 PMC9099959__F3 Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology CYP1A2 BRCA1 AHR PAH TRAF6 CYP1A1 PMC11732762__F2 CD28 signaling in FOXP3 expression and the effects of belatacept CD80 APC RELA FOXP3 MTOR PMC8839664__F6 Metabolism and Health Effects of Rare Sugars in a CACO-2/HepG2 Coculture Model LPL KHK EGR1 HMGCR TXNIP FASN KLF5 XDH ACACA TNF FOS SIRT1 PMC7056524__F1 In normal B cells, Mir-15/16 target Bcl2 BAX BAD BCL2 PMC5174080__F1 Innate and adaptive immune responses induced by Avian leukosis virus (ALV) IRF3 TLR7 PMC4905167__F1 Novel targets for ATM-deficient malignancies FANCD2 BRCA2 ATM SSB PARP1 PMC10417163__F2 Signaling pathways play an essential role in organizing the Golgi apparatus and maintaining neuronal polarity during neurogenesis GOLPH3 DAB1 HEL-S-36 MAJN PITPNB ARF1 ARHA PMC2597811__F1 Molecular Genetics of Colorectal Cancer: An Overview MSH2 PMS2 APC SMAD4 CTNNB1 PMC6376477__F11 Molecular mechanism of circHMGCS1: regulating miR-503-5p to control IGF signaling by functioning as a ceRNA GLS IGF1R IGF2 PMC3010690__F2 Zinc metalloprotease activity in APP processing IDE GLA APP PMC8987592__F2 TGFB/Smad Signaling Pathway in Tubulointerstitial Fibrosis SMAD2 SMAD4 TGFBR1 PMC8987592__F1 TGFB/Smad Signaling Pathway in Tubulointerstitial Fibrosis SMAD2 SMAD4 PMC7544055__F5 Toll like Receptor signalling by Prevotella histicola activates alternative NFKB signalling in Cystic Fibrosis bronchial epithelial cells compared to P. aeruginosa TLR4 RELB TLR5 PMC2855642__F2 Glycosylation of Alpha-dystroglycan POMT2 POMT1 FKRP PMC5116673__F3 Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis F11R GATA2 SMAD1 TGFB1 BMPR1A HMMR MEOX2 IGFBP2 ITGAV MMP11 FGFR2 HEL-S-14 BMP4 ITGA6 SHH MEIS1 SHC3 RCAN1 PAX3 MEOX1 ANXA3 MTUS1 PERP TBX5 GREM2 FGF10 COL18A1 CP PMC2612755__F5 A theoretical pancreatic endocrine tumor cell, smooth muscle cell (pericyte) or endothelial cell demonstrating the sites and mechanism of action of novel agents for the management of metastatic PETs FLT3 EGFR PTEN MTOR PMC8518663__F1 Manipulation of auxin signalling by plant viruses TPR SKP1 PMC8518663__F2 Manipulation of auxin signalling by plant viruses TPR SKP1 PMC3904723__F7 Putative functions of the differentially expressed proteins in metabolic processes of rice grain development at high temperatures HEL-S-162eP GIP HEL-S-11 PMC7448212__F6 Mechanism by which MCL attenuates the inflammatory response of NRK-52E cells NLRP3 IL1B PMC10177107__F1 Different signaling pathways and epigenetic mechanisms that have been deregulated during TNBC progression and growth, contributing to stemness ATR BRCA1 BRCA2 ATM PTEN MTOR PMC9108976__F2 Cellular and Developmental Roles of Cullins, Neddylation, and the COP9 Signalosome in Dictyostelium discoideum C6 CUL9 CUL5 DCUN1D1 UBE2M NAE1 CAND1 HEL-117 NEDD8 RBX1 CUL4A CUL7 CUL4B CSN3 UBE2F CSN2 PMC3958149__F2 Example of Janus kinase (JAK) inhibitors blocking cytokine signalling STAT1 JAK3 JAK1 PMC7905801__F1 IDO- and cell-mediated immunosuppression CD80 IDO1 APC PMC6501234__F9 Proposed molecular mechanism for LPS-induced downregulation of StAR expression and progesterone production in pGL STAR NR5A1 GATA6 GATA4 PMC6071399__F3 Analyzing Toll-like receptor signaling pathway by QIAGEN, KEGG and wikipathway websites and drawing pathway by Pathvisio software TES EED INS PMC7890234__F1 Activation of unfolded protein response BAX ATF4 EIF2A XBP1 TRAF2 PMC6387699__F1 Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications TET1 GC PMC10217562__F5 KEGG diagram of plant hormone signal transduction pathway under salt stress BIN2 EBF2 PMC5371797__F2A Non-Canonical Roles of Dengue Virus Non-Structural Proteins TBK1 MAVS IRF3 CS PMC3617338__F1 Multivalency and conditional regulation at the cell surface MGAT5 MGAT1 MGAT2 PMC2584013__F25 ER stress and ROS in NAFLD/NASH BAX ATF4 TRAF2 PMC3438932__F7 The role of dimeric TIR platform for the inhibition and activation of MyD88 signaling pathway IRAK1 IRAK2 IRAK4 MYD88 PMC10891858__F1 Investigating the Role of Non-Coding RNA in Non-Alcoholic Fatty Liver Disease TG FAS MTOR PMC7054754__F2 Core signalling pathways maintaining human pluripotent stem cells (hPSCs) SMAD2 LRP5 SMAD4 LRP6 NODAL IGF1R MYC INS CTNNB1 FGF2 PMC10891858__F4 Major signaling pathways by ncRNA in NAFLD/NASH as discussed in the text (Created with BioRender MTOR PMC7054754__F1 An overview of class IA PI3K signalling ACLY MTHFD2 MAF1 CAD TXNIP HK2 ULK1 UVRAG POLI PFKFB2 PTEN MYC EIF4E USP14 TSC2 EEF2K PI3 TFEB EEF2 BCL2 ATF4 MDM2 CCND1 PMC2584013__F23 TNF-induced and ROS-dependent events in target cells: the role of JNK activation in mediating cell death TRADD APAF1 TRAF2 RAC1 FADD PMC4918704__F1 TLR4 (toll-like receptor 4) signaling: MyD88 (myeloid differentiation primary response 88)-dependent and MyD88-independent pathways mediate TLR4 signaling TIRAP TICAM2 CD14 CXCL2 IRF3 IL6 CXCL6 TNF CCL2 CXCL8 MYD88 TICAM1 TLR4 CCL20 PMC4546439__F1 Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened SUFU PTCH1 SMO GLI3 PMC4546439__F2 Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened FAS SOX2 MMP2 BCL2 ATM MMP9 PMC10478475__F8 Hypothesized mechanism by which Ex-4 reduces tau hyperphosphorylation via Wnt/Beta-catenin/NeuroD1 signalling in T2D models NEUROD1 APC CTNNB1 PMC12215756__F10 NCC cellular metabolism is coupled to a developmental program SNAI2 FOXD3 SNAI1 GLS WNT1 HEL-S-30 PMC9433570__F9 Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism KLHL9 UBE2C CDC20 RRM2 KIF20A EHF PTPRK CXCL6 CLEC3B CXCL3 RAP2C CHI3L1 TFPI2 NGF XB ALDH3A1 CCNB1 IL1B PMC5428311__F3 Summary of the major global regulatory responses of S PTS SPI1 TNLG7C PMC4438467__F1 Mitochondrial cholesterol trafficking in regulation of macrophage sterol metabolism LDLR CYP27A1 ABCA1 PMC8187249__F2 Protected complex of biofactors and antioxidants improved growth performance and modulated the immunometabolic phenotype of broiler chickens undergoing early life stress STAT3 TIRAP TLR7 IL23R TRAF2 SIRT1 PMC6491684__F8 Schematic representation that hypothesizes the effects of ethanol (A), THC and/or OEA (B) on neurotrophic signaling pathway via AKT and ERK1/2, and its neurogenic response in the hippocampus MKI67 DCX NTF3 CASP3 BDNF PMC3030733__F1 Interventions in nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 signaling pathway KEAP1 NQO1 MAF PMC3308892__F4 ER stress-associated miR-346 induction TAP1 XBP1 PMC7530341__F6 Proposed gestational age-dependent changes in placental TRP metabolic pathways SLC3A2 SPR HEL-S-90n KYNU KYAT1 PTS SLC22A3 AANAT ASMT SLC7A5 DDC PMC5460696__F1 Schematic of androgen synthesis illustrating the classic androgen pathway (gray boxes) and the steroids of the 11-oxygenated androgen pathway (black boxes) CYP17A1 HSD11B2 PMC5491785__F7 Schema of the putative mechanisms by which myostatin may influence the function of bone cells DKK1 SMAD2 NFATC1 PMC8278082__F7 Naa10p and IKKA interaction regulates EMT in oral squamous cell carcinoma via TGF‐B1/Smad pathway TGFB1 SMAD4 PMC10039534__F2 Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment IFNG NEDD4 GSK3B IL2 B2M FOXP3 CXCL10 PMC4520755__F1 Canonical Notch signalling pathway and relevant pharmacological inhibitors under development in cancer CCND3 MAML1 CDKN1A DLL4 JAG2 NRARP MYC DLL3 PMC4520755__F2 Canonical HH-signalling pathway and pharmacological inhibitors targeting this pathway that are under ongoing development as anticancer therapies BMI1 KIF3A CCNE1 SUFU DHH SMO MYC CCND1 GLI3 PMC4520755__F3 Canonical Wnt signalling pathway and pharmacological inhibitors under investigation in cancer CD44 BCL9 MMP7 PPARG COX2 APC LRP5 LRP6 CCND1 HNF1A CTNNB1 PMC3531707__F3 PERK signaling under virus attack ELF2 ATF4 XBP1 PMC7456554__F3 Toll-like receptor (TLR) pathways deregulated in systemic sclerosis (SSc) TBK1 TIRAP MAL CD14 IRAK1 IRF3 TRAF3 TRAF6 MYD88 PMC9095362__F2 Cancer Stem Cell-Derived Exosomes in Cancer Progression CRP ERBB3 STAT3 COL18A1 THBS2 ERBB2 PTEN PMC7996755__F2 Targeting Nrf2 signaling pathway in chemoprotection KEAP1 ORM1 PMC9095362__F3 Cancer Stem Cell-Derived Exosomes in Cancer Progression CDH2 PTEN PMC7996755__F3 Nrf2 signaling in mediating DOX resistance of cancer cells LPA CD44 PMC9095362__F1 Cancer Stem Cell-Derived Exosomes in Cancer Progression DGKA RECK ACTN4 PTEN PMC7996755__F1 Schematic presentation of Nrf2 signaling pathway RBX1 KEAP1 GCLM GCLC PMC9656931__F10 Protective Effect of the Polysaccharides from Taraxacum mongolicum Leaf by Modulating the p53 Signaling Pathway in H22 Tumor-Bearing Mice BAX CD19 PMC10510267__F8 MCL’s protection against PD-related peritoneal fibrosis TGFB1 SMAD2 PMC7876405__F1 p38MAPK-MK2 axis is activated in response to diverse inflammatory stimuli MAP3K7IP1 TRADD TLR3 TLR4 TAB3 IL33 TRAF6 TNF TRAF2 MYD88 PMC5058662__F3 RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney CD40 CD80 JUN CCL3 TLR4 AKT3 CCL4 IL6 CCL5 TNF FOS IL1B PMC5923345__F1 NF2/merlin-Hippo signaling cascade dysregulation LIN28B PLCB4 MYC VGLL4 YAP1 LATS1 CD44 FOXM1 LATS2 AMOT AJUBA NF2 CCND1 PMC5923345__F2 Signaling cascades and molecules that affect Hippo pathway signaling and YAP1/TAZ activation in MM cells LATS1 LATS2 RHO MTOR YAP1 CTNNB1 PMC6016729__F6 Where Hematopoietic Stem Cells Live: The Bone Marrow Niche SBDS DICER1 CTNNB1 PMC4613848__F1 RASSF1A/LATS1/CDK2 pathway upon fork stalling LATS1 ATR ATRIP RAD51 WRN BRCA2 CDK2 BLM PMC6604204__F11 Schematic model of how minocycline may inhibit TNF-Alpha-induced cell fusion MMP3 MMP9 SRC PMC8607372__F3 Cytosolic and nuclear recognition of virus and viral evasion TBK1 MAVS TRIM25 IRF3 DHX58 TRIM65 PMC4613848__F2 RASSF1A regulation of the Hippo pathway in response to DNA damage LATS1 ATR RAF1 CDK2 ATM YAP1 PMC3087924__F1 Autophagy in macrophages STAT3 MTOR PMC8607372__F4 Cytosolic and nuclear recognition of virus and viral evasion TBK1 CGAS IFI16 IRF3 PMC10951359__F6 CGRP-induced anxiety-like behavior through epigenetic regulation of the p-HP1G–KLF11–MAOB–dopamine pathway TIEG2 HP PMC2464594__F4 Oct-4 Targets in the Wnt Signalling Pathway PPARG RBX1 SIAH1 APC GSK3B LRP5 CER1 LRP6 SKP1 NLK PROC PMC5270432__F4 rno-miRNA-mRNA network affecting VEGF signaling pathway based on the first global prediction.VEGF: Vascular endothelial growth factor CHP2 MAPK11 RAF1 PXN NFATC2 PIK3R2 PPP3R1 SPHK1 MAPKAPK3 PLA2G5 SHC2 PLA2G2D MAPK3 PRKCB PLA2G2A MAPK14 PLA2G10 SPHK2 PRKCA NRAS MAPK1 CASP9 NFATC4 MAPKAPK2 PLA2G2C NFAT5 NFATC3 PLA2G4B PMC5791370__F4 Proteomic analysis of the genes in Xllp08 and wild-type E SDHA SDHB MAL PPY CIT PMC9572368__F2 Ubiquitin–Proteasome System (UPS) and Viral Infection in Plants NBR1 RBX1 C2 SKP1 PMC8607372__F1 Cytosolic and nuclear recognition of virus and viral evasion DDX19A IFIT5 TBK1 MAVS TRIM25 NLRP3 IFIT1 IRF3 DHX58 TRIM65 PMC8607372__F2 Cytosolic and nuclear recognition of virus and viral evasion TBK1 CGAS DHX36 NLRC3 IFI16 IRF3 TREX1 MYD88 PMC5238783__F2 miR-22 services as onco-miRNA to promote tumor malignant transformation MAPK1 CCND2 PTEN PMC7343820__F8 AChR antibody-induced effects on myotubes expressing AChR clusters MUSK LRP4 PMC6945172__F5 Schematic of fatty acid Beta-oxidation, oxidative stress response and cholesterol absorption processes in the enterocytes of mouse ABCG8 ABCG5 MTTP GSTM3 CD36 ACAT2 NPC1L1 LOC51064 PMC2698322__F4 Key proteins regulated by PKB that are involved in metabolism (yellow); cell cycle progression (green); cellular growth (red); cell survival and apoptosis (blue); angiogenesis (orange) and neurological processes (purple) TSC2 BAD TSC1 MDM2 PMC4589385__F1 Bioinformatics Analyses of the Role of Vascular Endothelial Growth Factor in Patients with Non-Small Cell Lung Cancer CDC42 MAPK1 CASP9 BAD RAF1 PXN NFATC2 AKT3 MAPKAPK2 PIK3R1 SHC2 PTGS2 VEGFA PPP3CA SH2D2A RAC1 PRKCB HRAS PLCG1 SPHK2 HEL-S-102 MAP2K1 KDR SRC PMC2698322__F3 Complex relationship between PI3-K, mTOR and PKB signalling RHEB MLST8 TSC2 RICTOR TSC1 PTEN MTOR PMC4632950__F3 Molecular complexes involved in the calcium signaling pathways responded to BPS and WEX treatments TRDN HEL-S-99n AKAP5 ASPH PMC8032655__F6 Cell cycle at high altitudes (The purple boxes represent enzymes or genes, green box represent down-regulated) EGF INSR SMAD4 PTEN GRB2 INS PMC9260044__F2 Novel Insight of CircRNAs in Cervical Cancer: Potential Biomarkers and Therapeutic Target FOXM1 TFCP2 SOX9 PMC4632950__F2 Molecular complexes involved in the integrin-linked kinase signaling pathway responded to BPS and WEX treatments BMP2 HEL-S-28 PTEN HIF1A MTOR NCK2 PMC8874522__F2 Cerebellar and Striatal Implications in Autism Spectrum Disorders: From Clinical Observations to Animal Models DRD1 DRD2 HEL70 PMC7671463__F3 Cell signalling influences immune response and resistance to immunotherapy IFNG MTOR CTNNB1 PMC7359798__F2 Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids TBK1 MAVS XRN1 MLKL IFIT1 IFIT2 TRAF6 MYD88 DCP2 NLRP6 NLRP3 ZBP1 DHX36 DHX15 RNASET2 TLR8 TLR7 RNASEL NLRP9 IRF3 IRF7 RAC1 IFIT5 RIPK3 TASL RAF3 IFIT1B TLR3 DHX29 TRAF2 FADD PMC9331395__F6 Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD+ Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase MSH6 MSH2 PMS2 PARG PARP2 PARP1 MGMT PMC7359798__F3 Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids TBK1 CGAS MAVS TLR9 TRAF6 MYD88 BCL10 NLRP3 APOBEC3F APEH IL16 DNASE2 PLD4 PLD3 HMGB1 RAD50 AIM2 IFI16 IRF3 IRF7 TFAM TASL NONO TREX1 CARD9 ZCCHC3 PMC6953032__F3 JNK pathways controlling contradictory responses in neurons ATF3 SPRR1A KIF6 ATF2 PMC11626976__F6 Interaction role between TRIM family and p53 signaling pathway in GI cancer TRIM32 TRIM28 TRIM24 TRIM25 TRIM67 MDM2 TRIM59 TRIM23 PMC11626976__F4 Interaction role between TRIM family and STAT3 signaling pathway in GI cancer STAT3 TRIM14 SPHK1 TRIM52 MMP2 TRIM66 MMP9 TRIM29 PMC11626976__F5 The TRIM family in the TGFB signaling pathway in GI cancer TRIM25 TRIM47 CCL15 SMAD2 SMAD4 PMC11626976__F2 Interaction role between TRIM family and Akt signaling pathway in GI cancer TRIM44 TRIM14 TRIM32 TRIM24 PTEN TRIM59 PMC11626976__F3 Interaction role between TRIM family and Wnt/Beta-catenin signaling pathway in GI cancer MMP7 TRIM32 APC CTNNB1 TRIM50 TRIM28 CARM1 TRIM24 TRIM15 TRIM11 TRIM58 TRIM29 CCND1 PMC3670242__F1 JAK-STAT pathway and hematopoietic stem cells from the JAK2 V617F perspective STAT3 AK2 PMC8310348__F1 Immunity and Viral Infections: Modulating Antiviral Response via CRISPR–Cas Systems TBK1 CGAS MAVS TLR9 AIM2 IRF3 IFI16 IRF7 MYD88 TLR3 TLR8 TLR7 IL1B PMC6543669__F2 LncRNA/pseudogene–miRNA–mRNA ceRNA network in CRC ZFP82 SOBP RASSF2 RIMS3 CSF1 SCML1 ADAMTSL3 SCARA3 ZER1 SLC30A4 KCTD1 ATP11A RUNDC3B HECW2 KCTD12 SNRPF EDIL3 PLPP3 FGFR2 SIDT2 AGAP3 ZNF662 WWTR1 RNF125 ATP8B2 TARBP1 TTLL7 TSPAN18 ZNF655 FGFR1 OSBPL1A MEIS1 CPEB2 SPG20 STX1A NTN1 HOMER1 PCDH7 SOX12 L1CAM APC C7orf24 PID1 TMPRSS3 SNCG FOSL1 BCL2 HELLS VAMP2 AKT3 AMOTL1 LRP11 PI15 DPYSL3 TNS1 PLEK MYLK NCAM1 ARNT2 OLFM1 TMEPAI FST CYP26B1 EPHB4 CD48 HAPLN3 ABCB6 GNAL LPAR1 PITX2 CHPF FGF2 FGF7 NRG1 CIDEC SRPX STC1 UST RIPOR2 RBM28 PMC7445374__F2 Contact system in disease states C2 C1S C1R PLG A2M C4A PMC3245550__F2 Arf Family G Proteins and their regulators: roles in membrane transport, development and disease GBF1 ARF1 ARF3 ASAP1 ARF4 ARL1 ARF5 PMC7998362__F7 Four identified pathways responsible for P TH CPOX SPR PTS PAH TYRP1 XDH FECH UROD UROS PMC3527886__F2 Network of biglycan signaling in osteoblast differentiation and stabilizing role of biglycan in skeletal muscle SMAD1 DKFZp781O1323 WNT3A SMAD2 SMAD4 CTNNB1 PMC7818013__F1 DNA double-strand break repair pathway choice: a new focus on 53BP1 ME2 RNF168 RNF8 ATM RIF1 MDC1 PMC8783345__F4 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease RELA PMC8783345__F5 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease TH MAL PROC PMC6769485__F2 Anti-apoptotic and cell survival activities of some HSPs in cancer BAX FAS PAF1 PMC6769485__F3 HSP90 functions as a mediator of many oncogenic and signaling pathways CDC42 STAT3 BAX FAS EGFR APC GSK3B BCL2 SRC CTNNB1 FADD PMC6580974__F9 Network diagram displaying the IAV-dependent phosphorylation changes in the actin cytoskeleton and focal adhesion KEGG pathways JUN BAD PXN F2 APC PC PTEN ARHA INS CR1 PMC12055712__F8 Model illustrating the regulatory role of Roraa in circadian rhythms and metabolism PER3 RORC PER2 RORB TEF NFIL3 BMAL2 PMC8783345__F6 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease POR TH MAL PMC8783345__F7 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease MOK MAL CP PMC10530670__F5 Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Apoptosis, TNF Alpha and Interferon Gamma Response Gene mRNA Expression in T Lymphocytes CAD CASP2 ATM APP TNF BIK DIABLO FADD PMC6354076__F1 Sirtuins and metabolism SIRT3 SIRT7 SIRT4 SIRT5 SIRT2 SIRT1 SIRT6 PMC6354076__F2 Sirtuins and B lymphocytes SIRT3 BCR SIRT4 GC CD5 SIRT2 PREB SIRT1 SIRT6 PMC6329746__F6 Molecular signaling pathways relevant to the resistance to MAPK pathway inhibitors RPS6 CDK6 MTOR CDK4 PMC7920740__F3 Description of antioxidant enzyme system regulation via the Keap1-Nrf2-ARE pathway KEAP1 MAF PMC3294214__F2 Signaling pathways regulating epithelial immune response in nematode epidermal (a) and intestinal (b) cells, adapted from Tan and Shapira SGK1 PMC7818013__F3 DNA double-strand break repair pathway choice: a new focus on 53BP1 RAD51 BRCA1 RNF168 RNF8 RIF1 MDC1 PMC6471594__F2 Cilia-dependent regulation of the Hedgehog signaling pathway SUFU PTCH1 SMO PMC6471594__F3 Cilia-dependent regulation of PDGFRA signaling pathway PI3 PDGFRA IFT20 PMC7906909__F8 Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer BAX RAD51 F2 MTOR PMC7762141__F2 Host immune response against P TIRAP CCR6 TLR9 CCR4 IRF3 NOD1 CS IL1B MYD88 PMC7045519__F3 Epigenetic regulators in ferroptosis ELAVL1 BAP1 WDR76 FADS2 PMC3136937__F4 Identification and Analysis of Signaling Networks Potentially Involved in Breast Carcinoma Metastasis to the Brain HEL-S-103 NASP HEL113 TRIAP1 PGLYRP1 HSBP1 VHL ZMAT3 ENG RPS10 HNRNPA2B1 RPS3 ASB9 MB CDC37L1 PMC3847901__F2 Rat sarcoma viral oncogene homolog (RAS) activation converts normal keratinocytes to an initiated phenotype through a series of potentially reversible autocrine signals EGF FYN EGFR CXCL1 CXCL2 IL8RB MMP9 CXCL6 SRC MYD88 PMC6621562__F1 Ubiquitin regulations on mTOR signaling components SZT2 ITFG2 SGK1 ULK1 PTEN FLCN MTOR CASTOR1 DEPTOR RAC1 IRS1 RHEB TSC2 RICTOR TSC1 PHLPP1 SH3BP4 NPRL2 TFEB C16orf35 TBC1D7 DEPDC5 PMC3847901__F3 Divergent roles of myeloid differentiation factor 88 (MyD88) in colon carcinogenesis NLRP6 NLRP3 MYD88 PMC7045519__F1 Known function of organelles in ferroptosis STAT3 CHAC1 ARF1 GPX4 FACL4 GCA RIPK1 SLC7A11 ATF4 PMC4180336__F2 Bile acid biosynthetic pathways CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC5111231__F2 Hypothetical pathway regulating the response of skeletal slow twitch muscle to endurance training: myogenesis, fuel usage, and myosin fiber type change MYOD1 MAL HIF1A MBTPS1 MEF2C PMC4132015__F5 Notch, TGF-Beta, Wnt, Hedgehog, JAK-STAT and MAPK pathways LTBP1 EGFR IL3 EPO SMAD4 NUMB NODAL TGFBR1 IFNG FST IL2 SMO RAB23 GAS1 HES1 HES5 THBS1 PIM1 SP1 APC IL6 ARHA PITX2 SUFU SKP1 NLK ZIC2 CP PMC9136572__F3 Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases NLRP3 OMP S1PR2 CD36 TLR4 DFNA5 PMC8137523__F1 Inhibition of the mevalonate pathway by statins affects several outputs and lipid-regulating transcription factors GGPS1 ACLY UBIAD1 PDSS1 RHO NUS1 MVK INSIG1 HMGCS1 ACSS2 IPP HMGCR PMVK LDLR MVD FDPS IDI1 FDFT1 PMC8137523__F2 Oncogenic signaling pathways play a dual role in generating tumor hallmarks that increase demand for mevalonate pathway intermediates while concurrently upregulating mevalonate pathway meet the demand ACLY RHO GRB2 CTNNB1 PMC7550403__F1 Pathways of complement activation with complement regulators and inhibitors highlighted CD59 FH HEL-S-62p VTN CD46 CD55 C4A C4B_2 CP PMC4831273__F9 How the source and context of activated GAs and cAMP may determine whether they enhance or inhibit TCR-stimulated IL-2 transcription PLCG1 LAT HEL-S-11 LCK PMC4180336__F5 Bile acid feedback inhibition of bile acid synthesis FGF8A NR2A1 CYP8B1 FGFR4 PMC9136572__F2 Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases FAS CYP8B1 VLDLR APOE FGF8A TG NR1C1 ANGPTL3 INSR CYP7A1 NPC1L1 LDLR GCA PLTP FOXA2 CYP27A1 PMC9277228__F2 Necroptosis and Neuroinflammation in Retinal Degeneration SHARPIN RIPK3 TBK1 TRADD MLKL RIPK1 TRAF2 FADD MYD88 PMC1855990__F2 Identification of Key Processes Underlying Cancer Phenotypes Using Biologic Pathway Analysis CREBBP KIT PMC8137523__F5 Prenyltransferase biology is key to identifying targets of statin anti-cancer effects PTAR1 RABGGTB RABGGTA SKP1 RHO FNTA PMC8137523__F6 Rational combinations enhancing the effects of statins at the mitochondria BAX GPX4 BCL2 ABCA1 DHODH PMC8137523__F4 Tumor suppressors act as a checkpoint for mevalonate pathway flux by suppressing SREBP activity KIF3A PML PTEN ABCA1 INSIG1 VHL PMC5343835__F3 Proposed interaction of AQP1 with Wnt/ Beta-catenin signalling and cadherin-catenin complex APC GSK3B LRP5 LRP6 CCND1 CTNNB1 AQP1 PMC2817557__F2 Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota CSA2 TIRAP TLR4 NOD2 IRF3 LBP IRAK4 PMC5872357__F1 Epac signalosome in cardiac hypertrophy and ischemia RYR2 GHRH GHRHR PMC5584153__F4 Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis EGF BAD PTEN CXCL8 CCND1 FGF2 PMC4171211__F11 Proposed model of tetrandrine-induced apoptosis in prostate cancer BAX FAS FADD PMC9166517__F8 Network Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis MAX ECSIT EGF JUND FAS TRADD CD14 TNF DAO FLNA HP NLK GCK GRB2 TRAF2 PMC8103031__F2 CBP-JMF: An Improved Joint Matrix Tri-Factorization Method for Characterizing Complex Biological Processes of Diseases FOXA1 NME3 MYB JUN UBC VAV3 PCNA VAV2 FOS RAC3 POLR2H ERBB3 BCL9 FOXM1 TFF1 CA12 RHOD RUVBL1 ERBB2 FGFR3 CENPA MCM2 CCND1 CD68 PMC8103031__F3 CBP-JMF: An Improved Joint Matrix Tri-Factorization Method for Characterizing Complex Biological Processes of Diseases ERBB3 MYB VAV2 MAPKAPK2 ERBB2 RAC3 CDC25B PMC10860311__F1 Ovarian clear cell cancer carcinogenesis ARID1A PIK3CA PTEN PMC7693401__F2 Toll-like 4 receptor signaling in MCs SNAP23 FYN TLR4 VAMP3 CD14 IRAK1 LYN ATF2 TRAF6 TNF IRAK4 MYD88 PMC7693401__F3 Control of TLR4-mediated signaling in MCs SOCS1 SNAP23 TLR4 IRAK1 ATF2 SOCS3 TRAF6 IRAK4 MYD88 PMC5094751__F12 Comparative Gene Expression Profiling of Primary and Metastatic Renal Cell Carcinoma Stem Cell-Like Cancer Cells HS3ST2 ACSL3 F2RL2 HLA-DPB1 CTNND2 POSTN EREG MGMT SAA1 MMP7 TIMP3 ADAM19 TMEM158 CLEC18B SYNE2 GLIPR2 UTY ADAMTS9 GPR179 GPRIN2 NOTCH2 TROAP BRK1 RNF213 CSMD2 EBPL HBEGF EFNB1 RNF183 CRLF1 HMGCR HPGD EDNRA BCL2 CP RAP1GAP VEGFC ITGB4 CXCL1 SPHK1 DPYSL3 ABCA1 NOX4 TGFBR1 TPM1 NTF3 CLU DET1 ARG2 PTN PDLIM7 MMP9 NEF3 FGF2 NEFH SFRP1 SYTL2 CFTR PMC9372913__F8 WNT4 overexpression and secretion in thymic epithelial tumors drive an autocrine loop in tumor cells in vitro JUN CELSR1 APC TLE4 LRP5 LRP6 TCF4 ATF2 MTOR RHO RAC1 CTNNB1 TLE2 CD44 TCF3 PMC7693401__F4 Molecular events involved in the response of MCs to mediators produced by cell damage and stress HMGB1 FYN TLR4 IL33 HIF1A TNF MYD88 PMC3864445__F2 Fermentative hydrogen production from glucose by E MAX HEL-S-133P PMC6771012__F3 Molecules and cellular pathways that contribute to thyroid cancer development ALK APC GSK3B BRAF TERT PTEN MDM2 MTOR RET CTNNB1 PMC2658537__F1 Sample signalling scheme showing pathways known to be active in melanoma TSC2 BAD TSC1 BRAF PTEN MTOR PMC3233530__F2 Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis SMAD1 ACVR2A RAF1 BMPR1A BRAF PIK3R1 PIK3C2A SMAD4 NODAL KRAS TGFBR1 RB1 ACVR1B PPP2R2A CREBBP GRB2 YWHAZ SMARCA4 PMC4531430__F6 miRNA–gene–pathway regulatory networks MYLK CXCL12 FGF12 VAV3 HMGCR LAMC2 ITGA2 FACL4 PRKAB2 GHR TNLG2B PMC4909106__F4 Innate sensing of Toxoplasma gondii and Plasmodium sp MAVS TLR9 IRF3 IRF7 TLR7 IRF8 MYD88 PMC10572711__F2 Major and other possible molecular pathways associated with NLRs in IBD MAVS ATG16L1 IRAK1 MAPK8 TRAF6 MYD88 NLRC4 MAPK14 NLRP1 NLRP12 NLRX1 GSDMD NLRP7 NLRP6 NLRP3 TLR4 NOD2 CARD9 PMC6326574__F1 Immunological mechanisms responsible for radiation-induced abscopal effect CGAS APC IRF3 MX1 PMC8517268__F7 Dynamic m6A mRNA Methylation Reveals the Role of METTL3/14-m6A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration METTL14 YTHDF1 METTL3 PMC6914705__F10 Schematic representation of how SteA suppresses the nuclear factor kappa B (NFKB) pathway NEDD8 SKP1 CAND1 PMC3478886__F1 Prognostic Value of Cell-Cycle Regulation Biomarkers in Bladder Cancer CDKN2A EGFR ERBB2 CDK2 MDM2 CCND1 CDK4 PMC3109595__F5 Gene regulatory network model for specification of the skeletogenic mesoderm lineage NRL HEL23 FOXN2 ERG FOXN3 PMC8250126__F1 Janus kinase signaling as risk factor and therapeutic target for severe SARS‐CoV‐2 infection JAK1 TNF ACE2 PMC6152668__F3 DET- and IDET-induced apoptosis in different cancer cell lines BAX FAS MTOR FADD PMC8861201__F1 Metabolic Engineering for Valorization of Agri- and Aqua-Culture Sidestreams for Production of Nitrogenous Compounds by Corynebacterium glutamicum NOG MAL CIT PMC7947867__F4 Model showing plasma membrane NKCC1 and mitochondrial respiration: a link through leucine? Aerobic respiration utilizes the KREBS cycle and the electron transport chain DNAJC3 XBP1 IRS1 PMC8761794__F2 CGAS/STING Pathway: A Novel Target for Cancer Therapy CXCL11 NOS2 CGAS SLC19A1 CXCL10 TNF PMC8761794__F3 CGAS/STING Pathway: A Novel Target for Cancer Therapy TBK1 CGAS IRF3 PMC8761794__F1 CGAS/STING Pathway: A Novel Target for Cancer Therapy TBK1 STAT1 STAT2 IFNAR2 IFNAR1 IRF3 CCL5 CXCL10 OAS1 TNF PMC10526343__F1 Comprehensive Review on Neuroimmunology: Insights from Multiple Sclerosis to Future Therapeutic Developments APC VCAM1 PMC4748726__F4 Network of osteogenic specific proteins regulated by BMP2 signaling BGLAP ALPL COL1A1 COL1A2 BMP2 SPARC IBSP RUNX2 SPP1 PMC9563116__F2 Biochemical Pathways of Cellular Mechanosensing/Mechanotransduction and Their Role in Neurodegenerative Diseases Pathogenesis LATS1 LATS2 BOC RHO CTNNB1 PMC9628242__F6 Tetrahedral framework nucleic acids promote diabetic wound healing via the Wnt signalling pathway VEGFA CCND1 LEF1 CTNNB1 PMC8835964__F8 Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer BAX ATF5 OPA1 MCL1 EIF2AK1 BBC3 PMAIP1 BCL2L11 PHB2 EIF2S1 STOML2 DELE1 DDIT3 OMA1 ATF4 BAK1 PMC8424636__F7 Nicorandil inhibits TLR4/MyD88/NFKB/NLRP3 signaling pathway to reduce pyroptosis in rats with myocardial infarction GSDMD NLRP3 TLR4 MYD88 PMC10565453__F2 Organelle-level mechanisms of mitochondrial quality control TH FIS1 OPA1 POC1A NRF1 MFF SIRT1 PMC7827341__F2 IL-1A signaling pathway IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC8143883__F6 MicroRNA-342 Promotes the Malignant-Like Phenotype of Endometrial Stromal Cells via Regulation of Annexin A2 ANXA2 MTOR PMC10565453__F3 Altered mitochondrial quality control in renal tubule cells under high glucose conditions STAT3 PINK1 FIS1 OPA1 TXNIP PGAM5 MFN1 MTOR MIOX TFAM PHB2 SIRT3 PACS2 CXCR4 NRF1 PMC7713123__F1 Pathway engineering in yeast for synthesizing the complex polyketide bikaverin ENO2 RPS2 HEL-S-68p HEL-S-49 CLC PMC12134904__F5 IL-2 Action JAK3 PTEN FOXP3 MTOR JAK1 PMC10298860__F11 Albino phenotype of ‘HJY’ might be modulated by a plastid retrograde signaling pathway POR PPCS PMC8471942__F1 Genetic Aberrations of DNA Repair Pathways in Prostate Cancer: Translation to the Clinic ERCC1 XRCC5 ATR RAD51 PRKDC ATM PMC4127075__F1 Regulation of EMT by KLF4 in Gastrointestinal Cancer BMI1 KLF4 CDX2 FOXM1 IFITM3 SPRR2A CCNB1 KRT4 CCND1 PMC4127075__F2 Regulation of EMT by KLF4 in Gastrointestinal Cancer CDH2 KLF4 STAT3 EGF EGFR SMAD2 SMAD4 MTOR NOTCH2 NOTCH1 CTNNB1 PMC9273993__F3 Multifaceted Roles of Chemokine C-X-C Motif Ligand 7 in Inflammatory Diseases and Cancer CXCR1 IL8RB MTOR PMC9877271__F1 Unfolded protein response and ER-associated degradation under freezing, anoxia, and dehydration stresses in the freeze-tolerant wood frogs ATF3 ATF4 PMC8515174__F2 Complement inhibition for the treatment of COVID-19 triggered thrombotic microangiopathy with cardiac failure: a case report MIA ADAMTS13 PMC6310057__F1 Potential targets of glucose metabolism for anticancer therapy HEL-S-133P HEL-S-162eP PMC6769561__F2 Schematic summarizing the molecular mechanisms contributing to cancer progression STAT3 EGFR FREP1 PMC5751948__F1 Activation of NFKB (nuclear factorKB) by canonical and atypical pathways LTA MAP3K7IP1 BCL10 RELA RELB PC TNF PMC2395050__F1 PG-recycling pathway of the wild type (A) and trapping of anhMurNAc-tripeptide in an ampD mutant (B) MPL DAP PMC10935119__F9 Enzastaurin, midostaurin, and lestaurtinib FLT3 PTEN MTOR PMC5447271__F1 Illustration of Wnt signaling cascades APC GSK3B AXIN1 LRP5 NLK CTNNB1 PMC9380940__F3 Causal network predicted for STAT3 regulator showing its relationship with obesity and inflammatory response, obtained using Ingenuity Pathway Analysis (IPA) STAT3 POMC CDKN2B PMC7821690__F1 Crosstalk Signaling and miRNA Deregulation in Obesity Related Breast Cancer STAT3 BAD HMGA2 FOXO1 PTEN MDM2 SRC FOS PMC4329227__F2 Pentose phosphate pathway and cancer HEL107 RPE ATM TIGAR MTOR SRC MYC PMC12076877__F3 Aryl hydrocarbon receptor: a new frontier in male reproductive system AHR AHRR PMC4884395__F1 Kynurenine pathway of tryptophan metabolism GFAP KYNU IL6 IL1B IDO2 PMC4344557__F2 Proposed mechanism of action of yerba maté on the modulation of the PI3K-AKT signaling pathway IRS1 CTNNB1 PMC4773443__F5 Metabolic intermediates regulate Yersinia virulence CRP HPR RELA PMC9268458__F1 Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research NR1i1 CYP2R1 GC DHCR7 PMC3629228__F2 De-Regulated MicroRNAs in Pediatric Cancer Stem Cells Target Pathways Involved in Cell Proliferation, Cell Cycle and Development ATR THBS1 PERP SMAD4 PTEN NODAL ARHA MYC IFNG TSC2 FST CASP3 CDK2 ATM SKA1 PMC11201201__F2 VEGFR activation by the VEGF family of growth factors and resulting downstream signaling pathways to angiogenesis and lymphangiogenesis VEGFB VEGFC PIGF MTOR VEGFA PMC4149734__F5 Turnover of proteins in metabolic pathways in barley leaves POR PGP HPR PMC8001935__F3 PPI-specific gene-regulatory networks of top 5 KDs in IGF-I and IR (eQTL mapping) PIK3R5 ITCH PRKCZ PTPRF PPP2CA PPP3CA ATP2A1 CSNK2B RPS3 INSR BCR OTX2 YWHAG CDH2 CGN ERBB4 IRS1 HRAS RAB11A FER PLCB1 FES MAP2K1 GRB2 KLC2 NCL PMC7961896__F2 Unfolded protein response (UPR) pathways in skeletal muscle ATF4 EIF2A TRAF2 PMC3024731__F2 Examples of the signaling role of Cdc42 in selective tissue cell types CDC42 ELL INS PMC7961896__F1 Molecular mechanisms regulating skeletal muscle mass SMAD2 SMAD6 ELF2 BNIP3 BMP7 PTEN IGF1R ATF2 MTOR RHEB TSC2 RICTOR IGF1 GDF11 MAF TRAF2 PMC9474891__F2 Role and regulatory mechanism of m6A methylation in the nervous system SRSF7 FOXM1 HNRNPA2B1 HK2 WTAP ADRB2 METTL14 IGFBP2 METTL3 MTOR HNRNPC MGMT PMC9335447__F6A MicroRNA global profiling in cystic fibrosis cell lines reveals dysregulated pathways related with inflammation, cancer, growth, glucose and lipid metabolism, and fertility: an exploratory study SHC1 MAK COCH PIK3R1 NTRK2 KIT VEGFA ARHA BAMBI IFNG RPS6KB1 BMP2 KDR REL SKA1 PMC7372882__F7 PI3K-AKT signaling pathway plays a central role in anti-TAO system of SP EGF BAD FAS ITGB4 MAK MCL1 TNFSF6 PTEN CXCL2 PTGS2 VEGFA TNF INS RAC1 IRS1 MAPK3 BCL2L1 INSR IL2 BCL2 MDM2 GRB2 CASP10 PMC5264313__F4 Microarray analysis reveals alterations in the expression of major pathways of cellular metabolism in response to changes in collagen extracellular matrix density.A PHGDH SHMT1 HEL-S-32 HIF1A HEL-S-51e PSPH PMC8189684__F3 MEScan: a powerful statistical framework for genome-scale mutual exclusivity analysis of cancer mutations PIK3CA KEAP1 EGFR PTEN SMC1A MTOR CDKN2A CDK12 BRCA1 NF1 NPM1 NFE2L2 MDM2 HEL-S-26 PMC7257216__F8 Schematic diagram illustrating the mechanism by which asiaticoside inhibited MMT and ROS generation TGFB1 SMAD2 SMAD4 PMC4786634__F1 Both signal 1 and signal 2 are required for NLRP3 inflammasome activation MAVS NLRP3 TXNIP MFN2 IL1B MYD88 PMC5706502__F5 NcRNAs involved in mTOR signalling pathway RHEB TSC2 LAMTOR3 PTEN IGF1R DEPTOR IRS1 PMC4352384__F5 Polymicrobial synergy and dysbiosis in inflammatory disease TLR1 SMURF1 MAL ARHA MYD88 PMC4352384__F6 Polymicrobial synergy and dysbiosis in inflammatory disease TLR1 NLRP3 TLR4 GSK3B CXCR4 IL1B PMC8444018__F4 Temporary Regulatory Deviations and the Coronavirus Disease 2019 (COVID-19) PCR Labeling Update Study Indicate What Laboratory-Developed Test Regulation by the US Food and Drug Administration (FDA) Could Look Like IVD APC PMC10840489__F3 Endosomal and cytoplasmic viral RNA sensing by RLRs and TLRs MAVS TLR3 IRF3 IRF7 TLR7 MYD88 PMC11758981__F1 Gut microbial regulation of lipids reflects the influence of gut microbiota on hyperlipidemia in various treatment methods ANGPTL8 LPL ANGPTL3 PMC4367433__F2 Pathway for protein modification by UFM1 UFL1 UBA5 UFC1 UFM1 PMC10604364__F3 Illustration depicting the formation and fate of hybrid cells TLR4 MSC CTNNB1 PMC4367433__F4 Pathway for estrogen-induced ASC1 ufmylation for ERA transactivation UFM1 SP2 CCND1 PMC6027295__F1 Main signaling pathways of adiponectin in healthy liver NR1C1 ADIPOR1 ADIPOR2 PMC4440546__F5 Context-dependent control of alternative splicing by RNA-binding proteins FASTK EGFR PMC1895802__F1 TGFB signaling pathway and mechanisms of inhibition during leukemogenesis SMAD2 SMAD6 SMAD4 PMC7273480__F9 Metabolic pathway analysis MOK SI SHE PMC7457738__F8 Proposed schematic representation for GAST in GC development and progression STAT3 GAS SRC MMP11 PMC3924831__F2 Apoptosis signaling under ER stress conditions BAX ATF4 EIF2A TRAF2 PMC6133308__F1 KEAP1-NRF2 pathway is altered in human lung cancers.Schematic of KEAP1-NRF2 pathway under homeostatic conditions (left), oxidative conditions (center) or synergistic conditions, for example in a cancer cell (right) KEAP1 GSK3B MAF PMC4252505__F3 Hras-Braf MAP-Kinase pathway visualized using GenMAPP software RAP1GAP MAPK1 JUN RAF1 MAP3K12 BRAF KRAS MAPK3 ARAF MAP3K2 RASA3 SIPA1 MAP2K4 MAP3K1 MBP NRAS MAPK10 RRAS MAP2K1 MAP2K2 PLCB3 PMC5719347__F7 Signalling pathways associated with PRDXs and hypothetical illustration of PRDXs in mouse spermatozoa HEL-S-22 HEL-S-128m FAS PRDX3 HEL-S-2a EGFR SRXN1 GLRX PMC8851036__F2 Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective Endocarditis COMP TLR4 HEL-S-11 VCAM1 MPO PMC10384495__F2 Molecular and Genetic Interactions between Obesity and Breast Cancer Risk STAT3 ADIPOR1 NR3A2 ADIPOR2 LEPR MTOR PMC6667461__F1 Overview of direct and indirect pro-allergenic immune responses to anti-ulcer drugs (AUD) TH HEL-S-92n FRK AHR IL6 PMC5613156__F3 NOD-like receptors control various forms of PCD in mammals and filamentous fungi TPR NWD2 NLRP3 APAF1 PMC2803786__F2 Network analysis of the top 250 predictor genes SAA1 VPS16 CAV2 HEL-S-2 CACNA2D2 IRF9 VAMP3 WASL DUSP4 TAP1 GBP1 KRT6B SUMO3 CEBPG HLA-F HTATSF1 RHOB SSRP1 HSPA4 AHR MYCBP AMFR CXCR4 PMC2198843__F1 Adhesion regulation of nucleocytoplasmic trafficking of signaling molecules APC HEL-S-28 CASK LEF1 PMC8575484__F3 Identification of Candidate Genes Related to Synovial Macrophages in Rheumatoid Arthritis by Bioinformatics Analysis BAD MAL PMC9467755__F2 Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future HMGB1 NLRP3 IL6 PMC10313304__F9 Exploring the active ingredients and mechanism of Shenzhi Tongxin capsule against microvascular angina based on network pharmacology and molecular docking MAX JUND FAS RAF1 TRADD FRK CD14 TNF FLNA MEF2C MPL NLK TRAF2 PMC3784473__F9 The Suf Iron-Sulfur Cluster Synthesis Pathway Is Required for Apicoplast Maintenance in Malaria Parasites LIPA IPP PMC7122562__F2 Viral infection suppresses autophagy ATG3 ULK1 IRS1 PMC7122562__F3 Viruses manipulate autophagy to promote their replication MAVS ARF1 EDEM1 SNAP29 UVRAG IRGM TUFM STX17 GBF1 TSC2 ATG3 ATG12 ATG5 PMC4562884__F1 Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development APC ROR2 LRP5 LRP6 RHO PMC8185109__F3 Mitochondrial ER contact sites in neurodegeneration FUS PINK1 VAPB PSD MFN2 GSK3B PC MCU APP ATG5 PMC10530616__F15 Schematic illustration for the effects of Actinidia deliciosa (kiwi) extract on pathways related to T2DM STAT3 BAD KEAP1 GSK3B PTEN SIRT1 PMC7891678__F1 TGFB as a gatekeeper of BMP action in the developing growth plate SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 ACVRL1 TGFBR1 PMC8727908__F2 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling BRD4 SNAI1 RELA IL6 MMP9 PMC8692109__F8 Human Alpha-defensin 6 (HD6) suppresses CRC proliferation and metastasis through abolished EGF/EGFR signaling pathway EGF DEF6 EGFR CCNA2 PMC8727908__F5 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling BRD4 POLL RELA POLI MMP9 CDK9 SMARCA4 PMC8727908__F6 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling ARID1A BRD4 MED4 RELA MMP9 PMC3812255__F2 Serotonin Gene Variants are Unlikely to Play a Significant Role in the Pathogenesis of the Sudden Infant Death Syndrome FEV TPH2 HTT PMC11748645__F8 PD-L1 monoclonal antibody improves left ventricular function by modulating the CD47/SHP2/SIRPA/SYK/FcGR signaling pathway in tumor-associated macrophages, thereby inhibiting cGAMP expression SYK CGAS NLRP3 IRF3 CD47 PMC8727908__F8 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling IL6 MMP9 NOX4 PMC5529431__F5 Representation of the putative signaling pathways involved in B-cell clonogenicity induced by interaction of S75X/p17R76G with p17R(s) CDC2 CASP9 PAK1 PAX2 CHEK2 CDK2 YWHAZ PMC11748645__F5 PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPA/SYK/FcGR signalings in tumor associated macrophages STAT3 SYK SIRPA MYC CD47 PMC1483167__F1 Liver X receptor opens a new gateway to StAR and to steroid hormones FAS CYP11A1 LDLR ABCA1 PMC3815023__F2 Functional Networking of Human Divergently Paired Genes (DPGs) RBM22 CDC20 PCNA CDC6 ISY1 SMAD4 MYT1 NHP2L1 PUF60 SKP2 MAGOH STAP2 AQR CCDC12 CHERP CDK2 STAP1 PMC12250376__F9 Overexpression of (P)RR in SHR and Renin-Induced HepG2 Cells Leads to Spontaneous Hypertension Combined with Metabolic Dysfunction-Associated Fatty Liver Disease TG CD36 FASN PMC11955602__F0 Diagram illustrates how herbal formulations and extracts derived from TCM exert potential effects on AD through modulation of the PI3K/AKT signaling pathway BAX BAD PTEN PMC9600997__F8 TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40 CD40 BAX TRAF1 TRAF3 TRAF6 PMC6826992__F9 Models of EGFR-ligand dependent pathway and EGFR-ligand independent pathway in EIS cells ERBB3 EGFR SRC PMC2891338__F1 Endotoxin binding: Schematic overview of the LPS, LBP, CD14 and TLR-4 signal transduction pathway TLR4 IL6 TRAF6 LBP MYD88 PMC7042390__F9 Wnt signaling pathway APC GSK3B LRP5 WNT7A WNT1 LRP6 WNT4 ARHA NLK WNT7B CTNNB1 PMC6617733__F1 Distinct molecular and morphologic features of apoptotic, necroptotic, and necrotic cell death RFWD2 CAP2 TRADD MLKL CYLD TRAF2 FADD PMC3410255__F1 Regulation of PTEN/PI3K/AKT pathway by microRNAs IGF1 PTEN CCND1 PMC4879160__F4 Sclerostin actions LRP4 LRP5 LRP6 PTH PMC12000830__F2 Regulatory role of MEG3 in cancer progression and suppression IL18 PTPN11 RASL11B PTEN IL6 PMC9004513__F1 MTORC1 Activity by Amino Acids and Growth Factors RHEB MLST8 TSC2 TSC1 NPC1 TBC1D7 FLCN MCRS1 MTOR CASTOR1 SLC38A9 PMC12000830__F3 MEG3 lncRNA: a key regulator of tumor suppression across multiple cancer pathways STAT3 BAX MMP2 MMP9 MTOR PMC10151763__F2 Klotho’s impact on diabetic nephropathy and its emerging connection to diabetic retinopathy BMP2 KL WNT7B RUNX2 CTNNB1 PMC6458732__F6 A leucine-rich diet modulates the mTOR cell signalling pathway in the gastrocnemius muscle under different Walker-256 tumour growth conditions STAT3 IL6 MTOR IRS1 PMC10151763__F1 Klotho’s impact on diabetic nephropathy and its emerging connection to diabetic retinopathy EGR1 IGF1 TLR4 SMAD2 TGFBR3 SMAD4 IGF1R ARHA ADAM8 CTNNB1 FGF23 PMC5543436__F1 a The subcellular localization of the three isocitrate dehydrogenase isoforms and their roles in normal cellular metabolism FAS HEL-S-26 PMC5418193__F1 Insulin/insulin growth factor signaling pathway and its activation by reactive oxygen species (ROS) TSC2 TSC1 PTEN PMC8595768__F3 Oxidative stress-induced damage of IDE and BVR-A is associated with development of brain insulin resistance IDE GSK3B MTOR PMC7407108__F1 Hippo pathway LATS1 FAT4 FRMD6 AMOTL1 RHO NF2 VGLL4 PMC8264455__F1 Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing KEAP1 MAF PMC8595768__F1 Insulin signaling GSK3B GRB2 MTOR IRS1 PMC5382875__F1 Cytosolic co-delivery of miRNA-34a and docetaxel with core-shell nanocarriers via caveolae-mediated pathway for the treatment of metastatic breast cancer CD44 CDK6 SIRT1 NOTCH1 PMC11668677__F6 Summarizing figure for NA protective effect on lung tissues against the toxic effects of radiation NOS2 TGFB1 ARG1 TNF PMC8197487__F7 Developments for Collagen Hydrolysate in Biological, Biochemical, and Biomedical Domains: A Comprehensive Review TF BAX CSA2 JUN BAD FRK PTEN SHE TRAF6 NGF FOXO1 NOD2 NOD1 CARD9 PMC8449777__F7 Schematic showing the mechanisms underlying miR-2337 induction of TGFB1 production in GCs TGFBR2 AGO2 TGFBR1 PMC8198882__F1 Inflammasome NLRP3 Potentially Links Obesity-Associated Low-Grade Systemic Inflammation and Insulin Resistance with Alzheimer’s Disease RHEB RICTOR FOXO1 MTOR PMC4054275__F11 Proposed regulatory mechanism of protein tyrosine phosphatases in C TF ATF1 ERG PMC6930621__F10 Hepatic metabolic pathways of Met VIT PMC8132252__F2 Biological and Clinical Factors contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19 VWF HEL-S-5 PC ADAMTS12 PMC9513044__F2 Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment STAT3 APC GSK3B CTNNB1 PMC7249743__F8 Potentially HCC-related KEGG pathways RFWD2 ATR FAS PCNA SMC3 SMAD2 SMAD4 PTEN MTOR MYC SKP2 CDK7 E2F4 SIVA1 ATM MDM2 CDK4 CDC2 BAX AIFM2 PERP DERA ORC3 ORC2 TSC2 IGF1 CDC45 CASP3 CDK2 PIGS PMC9513044__F1 Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment STAT3 NOS2 ARG1 PMC9697637__F2 Marine Natural Products from the Russian Pacific as Sources of Drugs for Neurodegenerative Diseases CDK5 GSK3B APP PMC6349152__F1 The role of SUMO in kidney fibrosis SMAD4 VHL TGFBR1 PMC7378533__F2 Type I IFN due to the activation of IFN receptors STAT3 STAT1 STAT2 JAK1 TYK2 PMC3773303__F3 Clathrin-dependent and -independent endocytosis of STx CDC42 SYK RHO PMC5845882__F8 gga-miR-155 and the suppression of IBDV replication SOCS1 TBK1 TLR3 TANK IRF3 IRF7 PMC7759095__F4 SARS-CoV-2 infection and signaling pathways as potential targets for treatment TMPRSS2 ACE2 PMC9057928__F3 Emerging roles of retromer and sorting nexins in the life cycle of viruses VPS35 SNX2 SNX5 SNX27 PMC1904449__F3 In silico modeling derived from Pathway Assist software analysis of differential gene expression in JRA neutrophils compared with healthy control subjects FOSB ADM TNLG7A MCL1 TNF PTMAP7 CD83 HLA-DRA CDA RALA FES HEL-75 GNLY PMC7896749__F3 LncRNA‐mediated posttranslational modification of other proteins involved in metabolic pathways FUS MDM2 SIRT1 PMC9576507__F3 Pyroptotic cell death in SARS-CoV-2 infection: revealing its roles during the immunopathogenesis of COVID-19 POR NLRC4 NLRP1 GSDMD NLRP3 IL16 AIM2 ACE2 PMC8893235__F2 Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals? BRCA1 tmp_locus_29 PSD ULK1 BNIP3 ULK2 PMC5751344__F3 Involvement of galectins during carcinogenesis HRAS APC GSK3B NRP1 ARHA CTNNB1 PMC9437339__F9 Apolipoprotein A-I mimetic peptides (ApoAI MP) improve oxidative stress and inflammatory responses in Parkinson’s disease mice STAT3 APOC3 GLRX2 CCS EGFR CD40LG IL1A TNFRSF6B NR3C1 STUB1 APOA2 LPA FKBP4 IL1R1 HBEGF PLCG1 NONO APOB EP300 AHSA1 CDC37 HEL-S-64p SIRT1 IL1B PMC2684021__F1 The fungal cell wall and downstream cellular responses following engagement of Dectin-1 and TLRs on antigen presenting cells (APC) SYK IL10 APC IL2 IL6 TNF CARD9 MYD88 PMC7038193__F3 Sp1 mediated tumorigenesis in ovarian cancer (OC) SP1 MDM2 SRC PMC8526690__F3 Mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues PIEZO1 SOST AIP MSC ATF4 HP PTGS2 RUNX2 TNFRSF11B CTNNB1 PMC4383556__F9 Transcriptome Analysis and Its Application in Identifying Genes Associated with Fruiting Body Development in Basidiomycete Hypsizygus marmoreus TSC2 EIF4B COMP RICTOR ACADS DCT TYRP1 HIF1A MTOR CTNNB1 PMC9460496__F9 Transcriptional Memory in Taraxacum mongolicum in Response to Long-Term Different Grazing Intensities C6 PC FES PMC3703549__F8 Ang II activates the Notch1/Snail signaling, which is responsible for the pathogenesis of proteinuria in diabetic nephropathy HES1 NOTCH1 PMC8911352__F2 Paediatric Behçet’s Disease: A Comprehensive Review with an Emphasis on Monogenic Mimics SHARPIN TRADD BCR OTULIN RELA RIPK1 PMC3697124__F3 Antibiotics doxycycline and minocycline inhibit inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi EGF LTA TIRAP RELB PMC5809464__F9 Lipid metabolic pathway analysis of identified differential lipid species PC TYW1 IMPACT PMC11410975__F0 ALKBH5 activated JAK2/STAT3 signaling pathway and mediated m6A demethylation on Stat3 mRNA, but not Jak2 mRNA, resulting in the phosphorylation and nuclear translocation of STAT3, which enhances the transcription of hypertrophic genes (e STAT3 NPPA ALKBH5 NPPB PMC2821954__F2 Portrayed here is a molecular pathway analysis of genes regulated in the mouse nucleus accumbens by a direct infusion of the HDAC inhibitor MS-275 after chronic social defeat stress REST TGFA STAT2 ADRA1A EGFR IFIT3 RHO JAK1 PMC6826893__F5 Crosstalk between RAS-ERK pathway and FOXM1 DUSP10 TH FOXM1 SKP2 PMC4713713__F3 Activation of autophagy and caspase-independent apoptosis pathway and proposed mechanism of action of magnetic nanoparticles functionalized with LL-37 on colon cancer cells BAX ATG5 PMC3019079__F1 The homocysteine and folate metabolic pathway RFC1 MTRR MTR PMC7494756__F1 Output and input pathways of the central circadian timing system in the mammalian brain that may be involved sundowning–related behavioral aggression and circadian dysfunction in Alzheimer’s disease and related dementias VIP NPY AVP PMC9499548__F4 Two Short Repeats in the 5′ Untranslated Region of Insulin-like Androgenic Gland Factor in Procambarus clarkii (PcIAG) That Regulate PcIAG Expression DVL1 JUN JUND MOS HEL-S-11 ARHA NLK PMC8967653__F1 Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins FAT4 LATS2 TEAD2 TEAD3 APP DCHS1 RET TEAD4 FBXL7 PMC7683721__F7 Signaling cascade for the aberrant TRPV4 and calcium activation in endometrial cancer PXN ROCK1 ARHA PMC11972515__F2 LncRNAs in acute myeloid leukemia IGF1R TUG1 PMC4595210__F4 Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice GPT2 ADORA2B ARRDC3 MAP2K2 EGR2 HES1 CP PMC9319091__F11 VMP1 Regulated by chi-miR-124a Effects Goat Myoblast Proliferation, Autophagy, and Apoptosis through the PI3K/ULK1/mTOR Signaling Pathway VMP1 MTOR PMC6721648__F2 Pathways of androgen action in the Sertoli cell TF EGFR SRC PMC5105060__F9 Analysis of Zinc-Exporters Expression in Prostate Cancer NAPA CSF2 SLC30A4 SLC30A8 B3GNT3 SNX27 DIRAS3 SLC30A7 SLC30A6 RBM25 SLC30A10 SLC30A2 SLC30A5 INSR SLC30A1 ELAVL1 CLPSL1 CCL4L2 CCL4 SLC30A9 PMC5094499__F1 Pleiotropic effects of hyperglycaemia‐induced miR‐126 underexpression and insulin resistance RAF1 SPRED1 PTEN IRS1 PMC6685059__F2 Translational challenges with systemic and local cell delivery TF HEL-S-62p TFPI CD9 MREG MSC CD46 CS PMC5418463__F1 Regulatory T (Treg) cells modulate CD8 T‐cell exhaustion, but the programmed cell death protein 1 (PD‐1) pathway determines viral control TNF PMC6778255__F8 Schematic view of the role of AvB3-int in PD-L1 expression and antitumor immunity STAT1 STAT2 JAK1 PMC6266222__F3 Regulatory effects on immune-related pathways induced by a group of compounds from health-strengthening herbs IFNG IFNGR2 IFNGR1 REN CANX FYN TAP1 B2M NFYC TAP2 GRB2 PMC6938582__F2 Action of metformin in endocrine tumors: metformin is a negatively charged molecule that enters the cell through organic cation transporters (OCTs) STAT3 ATF3 TSC2 TSC1 IGF1 EGFR MTOR CCND1 IRS1 PMC9596769__F3 Immunomodulatory potential of secretome from cartilage cells and mesenchymal stromal cells in an arthritic context: From predictive fiction toward reality NR1i1 IL10 IF2B1 IGF1 CCR5 IL4 SHH HIF1A IL6 IL9 PMC6744391__F9 TAAR1 signaling pathway/apoptotic pathway components BAX TAAR1 PMC4084927__F10 Acetaminophen and NAPQI are Toxic to Auditory Cells via Oxidative and Endoplasmic Reticulum Stress-dependent Pathways ATF4 EIF2A XBP1 PMC12060066__F4 Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies BAD VASP GC CNP ARHA TRPC6 INS PMC7198484__F4 Intracellular Staphylococcus aureus persisters upon antibiotic exposure SDHB LDHD CS PROC NR1A2 THRA PMC3280691__F1 Beta-catenin signaling: a novel mediator of fibrosis and potential therapeutic target APC AXIN1 LRP5 LRP6 AXIN2 CTNNB1 PMC7723172__F3 Effects and mechanisms of corosolic acid-induced anti-inflammatory and anti-MS activities NLRP3 IRS1 PMC8625880__F2 Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair RAD52 RAD51 LIG1 BRCA1 PAXX BRCA2 POLE PALB2 PARP1 PMC8625880__F3 Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair ERCC1 XPA DDB2 DDB1 CETN2 PCNA UVSSA XPC PMC4700926__F1 The core autophagy pathway and its regulation by miRNAs LAMP2 ATG10 ATG3 ATG16L1 ATG12 UVRAG BCL2 TBC1D2 ATG5 PMC2758293__F2 An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective CDH2 PATJ FER CRB3 GSK3B HEL-S-28 PALS1 SRC CTNNB1 PMC8615762__F1 Chemokine Pathways in Cutaneous Melanoma: Their Modulation by Cancer and Exploitation by the Clinician CCL27 CXCL9 CXCR3 EGF CXCL12 CCL22 HGF CCL3 CXCL5 CCR5 CXCL1 CCR2 CCL5 CCL2 CXCL8 CXCL3 CCL21 CCR6 CCR7 CCR10 CCR8 CCL1 CCL17 CXCL2 CXCL6 CXCL10 CXCR1 CCL25 CCR4 CCL4 IL8RB CXCR4 CCL20 PMC5574038__F6 The role of the Dishevelled DEP domain in Wnt/Beta-catenin signal transduction WNT3A LRP6 CTNNB1 PMC7721491__F4 Association of PPARs with neuroinflammation IFNG IL6 TNF PMC6976994__F3 Mechanistic aspects of DME regulation in mouse liver tumors with mutations in either the Ctnnb1, Hras, or Braf oncogene CYP2E1 AHR CYP1A1 CTNNB1 PMC9228804__F3 Tumor Suppressive Effects of GAS5 in Cancer Cells CDK2 PTEN MTOR CCND1 EIF4E PMC3882755__F8 A Receptor-Specific Function for Notch2 in Mediating Vascular Smooth Muscle Cell Growth Arrest Through p27kip1 CDK2 NOTCH2 SKP2 PMC5466396__F9 Crosstalk of hypoxia-induced endothelial-mesenchymal transition (EndMT) signaling pathways SMAD2 SMAD4 NOTCH1 RUNX3 PMC9228804__F6 Tumor Suppressive Effects of GAS5 in Cancer Cells RHEB TSC2 EIF4B TSC1 PTEN MTOR EIF4E PMC4682189__F2 Comparative transcriptome analysis of grapevine in response to copper stress POR CPOX UROD UROS PMC8755416__F2 Renal consequences of the novel coronavirus disease 2019 (COVID-19) and hydrogen sulfide as a potential therapy ACE2 DAO IL1B PMC3184987__F5 Activation-Induced Cytidine Deaminase (AID)-Associated Multigene Signature to Assess Impact of AID in Etiology of Diseases with Inflammatory Component EGR1 ID2 FCER1A FCER1G IL13 PAX5 CD14 CD19 IRF8 EGR2 ID3 CD3E PMC9181689__F2 Enhancing the Therapeutic Potential of Mesenchymal Stromal Cell-Based Therapies with an Anti-Fibrotic Agent for the Treatment of Chronic Kidney Disease TNF IL1B PMC5465356__F8 ATP-binding cassette transporter A1 regulates phosphoantigen release and VG9VD2 T cell activation by dendritic cells IPP MTOR ABCA1 PMC4991739__F5 Dynamically alternative pathway network CA3 CAV2 TNC BCR PIR PMC7161696__F9 Pathway of hyphal formation CDC42 NRG1 TPK1 OFD1 LMO1 PMC3091753__F3 Representative genes that responded to [BF/S+L/Ep] treatment NCAM2 SLA IKBKG SOX6 PPBP AMOT RBP1 SYCP1 NRXN1 HTT RBM14 CDH10 ABCE1 SP1 PER2 APC MAPKAPK2 OSCAR CXCL2 AHRR ACSS1 TWSG1 DMC1 NFKB1 SERPINB2 ASB2 PMC5345753__F1 Different molecular mechanisms that can induce time-delay necessary for the generation of oscillations in transcription factor activity MDM2 HES1 AXIN2 CTNNB1 PMC6668488__F7 A proposed schematic representation of Mn-dependent adaptive and toxic response pathways BET1 NDUFAF5 ARFGAP3 FABP5 ADAM10 PMC8325099__F7 Identification of novel biomarkers for arthrofibrosis after total knee arthroplasty in animal models and clinical patients TGFBR2 SMAD2 SMAD4 RHO TGFBR1 PMC3709248__F4 Nitr9L–Dap12 activation of cytotoxic cells ZAP70 SYK KIR2DS2 FYN SRC LCK PMC1933158__F6 A hypothetical model for the dual roles of insulin signaling in human brain IDE NEUROG2 MYC PAX6 PMC8306439__F3 Combining Oncolytic Viruses and Small Molecule Therapeutics: Mutual Benefits RHEB TSC2 TSC1 PTEN MTOR IRS1 PMC3145614__F1 Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium ELOVL2 FADS2 FADS1 PMC5601173__F3 SOCS molecules: the growing players in macrophage polarization and function STAT3 JAK3 STAT4 IL10RA TYK2 PMC4222248__F7 EGF signaling pathway to stimulate proliferation of conjunctival goblet cells EGF SRC PMC9496100__F3 Ginsenoside and Its Therapeutic Potential for Cognitive Impairment RB1 BAX BAD IGF1 GSK3B PTEN IGF1R MTOR FGF2 PMC7325921__F2 Quantification of intracellular carbon energy metabolism FBP1 PC GIP PCK1 PKLR PMC11617210__F10 ADRB2 serves as a novel biomarker and attenuates alcoholic hepatitis via the SIRT1/PGC-1A/PPARA pathway: integration of WGCNA, machine learning and experimental validation NR1C1 ADRB2 CXCL10 CCL2 CXCL8 SIRT1 PMC3764486__F2 Expanding roles for CD4+ T cells in immunity to viruses CD40 TH ICOS CD27 TNLG8A PMC4785262__F3 Neutrophil Functions in Periodontal Homeostasis SMURF1 MAL ARHA MYD88 PMC7542236__F1 PI3K/Akt/mTORC1 pathway, Ras/Raf/MEK/ERK pathway, mTORC2 signaling, and the EMT process RHEB SYK CSK ARHA SRC IRS1 EIF4E PMC4380230__F2 Endothelial cell metabolism in normal and diseased vasculature AGXT2 HMGCR HEL-S-162eP DHFR ARHA PARP1 PMC9181642__F8 Angiotensin II Inhibits Insulin Receptor Signaling in Adipose Cells PDK2 INS PMC3916982__F2 Crosstalk of signaling pathways in breast cancer and the potential clinical therapeutic targets RHEB BAD NF1 C2 EGFR BCL2 PTEN MDM2 EIF4E PMC8517487__F10 Expression of Microtubule-Associated Proteins in Relation to Prognosis and Efficacy of Immunotherapy in Non-Small Cell Lung Cancer ATR BAD PER2 EBP APC CYC1 CD46 PTEN PER3 TSC1 OASL CDK2 ATM PMC8526928__F2 Rhinovirus Immunity and Asthma STAT1 STAT2 IFNAR2 IRF9 JAK1 TYK2 PMC2677387__F1 mTORC1 activation by nutrients and growth factors RHEB MLST8 TSC2 RICTOR TSC1 PTEN MTOR PMC4324736__F3 Individual involvement of the products of the eight studied genes (shown in red colour) in the (a) RAS/RAF/MEK/MAPK, (b) PI3K/AKT, and (c) GNAQ/11 signalling transduction pathways HRAS GNA11 BRAF PTEN MTOR KRAS PMC7247819__F2 Activation and inhibition of the AIM2 and NLRP3 inflammasome in SLE, Ps, AD, and vitiligo NLRP3 PLXNB2 AIM2 TLR7 IL5 PMC5669850__F1 Role of the inflammasome in chronic obstructive pulmonary disease (COPD) TIRAP TLR3 TLR9 NOD2 TLR5 NOD1 RIF1 TRAF6 PMC10530962__F2 Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications SMAD2 SMAD4 PMC6000455__F1 mTOR信号通路mTOR signaling pathway RHEB EGF TSC2 TSC1 IGF1 PTEN IRS1 EIF4E PMC8484528__F5 Integrated Analysis and Finding Reveal Anti–Liver Cancer Targets and Mechanisms of Pachyman (Poria cocos Polysaccharides) STAT3 EGF PTPRC MMP9 VEGFA TNF FGF2 ALB HRAS BCL2L1 CASP3 SRC CXCR4 PMC6701435__F5 KEGG pathway analysis for HepG2 cells depicting the upregulated genes in the TNF signaling pathway after the treatment with TIT3; the altered genes are marked ALPI MMP14 FAS SELL TRADD ITCH SELE MLKL LIF MMP3 TNF FADD PMC6337474__F1 Top left: Wnt binds to the Frizzled receptor (Fz) and the LRP5/6 co-receptor BMP2 MSC PTH CTNNB1 PMC9181207__F1 Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis CYP8B1 BAAT CYP7A1 CH25H GCA CYP46A1 CYP7B1 CYP27A1 PMC2782725__F2 Cell cycle and acute kidney injury BAX PMC8607431__F7 Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy BRAF PTEN MTOR SRC YAP1 PMC8237188__F1 JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib IFNG JAK3 EPO JAK1 TYK2 PMC11941543__F2 Influenza virus interaction with autophagy MTOR PMC7493230__F4 Proposed mechanism for the EGFR/c-Met-mTOR/S6K signaling axis in NSCLC RHEB RPS6 EGF TSC2 HGF FOSL1 EGFR WEE1 LRP5 CTNNB1 EIF4E PMC6937862__F2 The graphical user interface and output of ZDOG MYB SYK PIK3CA CSF1 RAF1 SOS1 MCL1 GSK3B CRTC2 MYC BCL2L1 PDPK1 PRKCA PKN3 MDM2 CASP9 TNFSF6 IRS1 EIF4E HRAS RHEB MLST8 TSC2 TSC1 BRCA1 CDKN1B RXRA CDK2 BCL2 GRB2 BAD CREB3 AKT3 PTEN MTOR PCK1 CSF3 CSF3R YWHAQ PHLPP2 MTCP1 CHUK CCND1 RPTOR RPS6 EIF4B EIF4EBP1 RBL2 CD19 BCL2L11 ITGB1 MAGI1 GYS1 FOXO3A NFKB1 RPS6KB1 PMC5427079__F6 Reactome pathways displayed in Figure were converted into a functional interaction network using FI network view GPC4 CTRB2 LMF2 GPC2 CTRC APOF AMN APOA2 LIPC MTTP A2M TCN1 SDC2 PMC5427079__F5 Enriched pathway analysis: The entities in the diagram colored purple are hits within positive gene list STX4A STXBP3 PMC10739988__F2 Advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review) STAT3 EGFR MTOR PMC7709261__F1 Outline of TGFB signaling pathway regulating HCC initiation and progression CDH2 STAT3 THBS1 AXL PCNA EGFR MMP9 MYC KRAS TGFBR1 CTNNB1 CD96 TGFBR2 CD44 PMC1767116__F3 Mitochondrial death signalling pathways BAD DIABLO PMC7709261__F2 Function of lncRNAs in regulating TGFB signaling pathway to affect HCC tumorigenesis TGFBR2 KRT19 TGFBR1 PMC10657592__F1 Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering LPA EGF SMAD2 SMAD4 GRB2 TRAF6 RAC1 PMC8567041__F4 Integrative multi‐omics approach for mechanism of humidifier disinfectant‐associated lung injury SMAD2 MMP2 PMC8522789__F1 Clinical and Mechanistic Characteristics of Current JAK Inhibitors in IBD IL-21 IL10 IL2 IL6 JAK1 IL5 TYK2 IMPACT PMC8674945__F1 Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation CRP HEL-S-62p PLG VTN SRC HNRNPC PMC4607752__F5 BaP effects on the expression of BaP marker genes and genes involved in the AHR signaling pathway HEL-S-103 STAT3 SNAI2 THBS1 ABHD4 ANXA1 LDB1 HUNK NBEA EMILIN2 CELF2 MPO SLC22A7 FGFR2 TXN MYH7 GCLC NFE2L2 EN1 AHR FGFR3 APP PMC10725447__F0 Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/Beta-catenin signaling activation APC FAM83F CTNNB1 PMC5434467__F1 The structure of IL-35 and the activation of the JAK-STAT signaling pathway STAT1 EBI3 STAT4 PMC5814839__F8 P53 signaling pathway targeted by hsa-mir-34a in liver cancer TP73 ATR FAS CD82 CYCS PTEN BBC3 PIDD1 MDM4 CDK6 ATM MDM2 APAF1 CDK4 CCND3 BAX SIAH1 PERP RRM2 EI24 ZMAT3 DDB2 TSC2 IGF1 SESN3 CASP3 RPRM PMC8568984__F4 Cross-platform transcriptomic profiling of the response to recombinant human erythropoietin SLC4A1 CA12 RHAG AQP1 PMC6714137__F11 Schematic representation of inhibitory effect of miR‐539 on EMT and metastasis of PCa DLX1 SMAD4 PMC10173380__F7 Schematic diagram illustrating the mechanisms through which VNN1 in PC cells induces Beta-cell dedifferentiation by inhibiting the AMPK/GAPDH/Sirt1/FoxO1 signaling pathway VNN1 FOXO1 HEL-S-162eP SIRT1 PMC6966464__F2 Four ErbB receptors EGF BAD TGFA ERBB4 PTEN SHC2 MTOR ERBB3 NRG2 NRG1 HBEGF BTC ERBB2 GRB2 SRC PMC2195865__F1 Extrinsic and intrinsic cell death signaling pathways BAX FADD PMC5759086__F3 Metabologenomics of Phaeochromocytoma and Paraganglioma: An Integrated Approach for Personalised Biochemical and Genetic Testing TH PNMT DBH PMC6379280__F2 Rationale for choosing Arl13b, SMO, and melanin-concentrating hormone receptor 1 (MCHR1) as cilia-targeting moieties PTCH1 ARL13B SHH SMO MCHR1 PMC4082763__F1 Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease IPP RHO PMC8883943__F1 D-Amino Acids as a Biomarker in Schizophrenia DAOA ddo DAO PMC9693569__F1 Polyphenols for Livestock Feed: Sustainable Perspectives for Animal Husbandry? IPP RRH OMG PMC11891048__F2 S-palmitoylation is involved in immune response types STAT3 BAX SYK CD36 LAT APC ZDHHC4 SQSTM1 FOS ZDHHC3 ZDHHC11 PLCG1 ZDHHC12 PALM ZDHHC7 ZDHHC21 ZDHHC19 LYN ZDHHC5 ZDHHC8 LCK FADD PMC7600636__F2 Canonical pathway of STAT3 signaling STAT3 SOCS3 SRC PMC2820477__F2 Scheme of known Wnt pathways CDC42 RHOB APC ROR2 LRP5 LRP6 RYK ARHA PMC3675900__F2 Eicosanoids in Metabolic Syndrome LTB CD36 FADS2 ELOVL5 FADS1 PMC2996902__F1 CoQ10 biosynthesis pathway COQ7 PDSS1 COQ3 COQ2 COQ6 COQ5 PMC12075257__F7 Schematic model showing the role of WED in regulating megakaryocyte differentiation and platelet generation GATA1 FOS PMC2820477__F1 Schematic junctional organization and Beta-catenin signaling in CNS ECs: comparison of brain and retina ESAM TSPAN12 PC ABCB1 CTNNB1 PMC3962112__F1 Biosensor-derived promoters upstream of modules B and C to control the expression of fadD and atfA, and the ethanol biosynthetic pathway (adhB and pdc), respectively FAS PDC FADD PMC10620831__F8 PRMTs regulate antiviral innate immunity PRMT1 TBK1 PRMT7 CGAS PRMT2 PRMT3 MAVS PRMT6 IRF3 IFI16 TRAF6 TLR4 PRMT9 PMC5488238__F6 BMP–Notch interaction in intestinal homeostasis and CRC disease subtypes BMPR2 MAML1 ID2 BMP4 BMP2 ID1 ID3 PMC7075948__F1 Interferon (IFN) signaling enhancement by the inhibition of the Wnt pathway through miR-34 TBK1 GSK3B IRF3 PMC7492298__F6 Granulosa cells undergoing apoptosis BAX CASP9 FAS CASP8 TNFSF6 CASP3 BCL2L11 FSHR FADD PMC7836322__F2 Replication cycle of HCoV HEL-S-69p DPP4 ACE2 PMC9574713__F7 Temporal Alterations of Sphingolipids in Optic Nerves After Indirect Traumatic Optic Neuropathy UGCG GBA2 UGT8 PMC6757160__F2 General mechanism of SYK activation and SYK-mediated signaling: a pathway demonstrating the involving of downsignaling associated with SYK activation SYK NLRP3 CFTR PMC6705574__F8 The mechanisms underlying contributions of YAP/TAZ/Beta-catenin to the spinal central sensitization after nerve injury and regulation of dCTB on YAP/TAZ/Beta-catenin and Hippo signaling pathways LATS1 LPA LATS2 APC GSK3B PS1TP5BP1 CTNNB1 PMC7018500__F1 Signaling pathways involved in the recognition of HSV STAT1 CGAS TLR3 STAT2 IRF9 TLR9 IRF3 IRF7 TRAF3 JAK1 TYK2 MYD88 PMC11016017__F3 Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling BAX ATR EGFR SMYD3 SOX2 MTOR TNF IRAK4 CD44 CD24 COX2 ATM SIRT6 PMC7607115__F2 Model for TERT promoter mutations, TERT expression and telomerase activation during the pathogenesis of TC CDKN2A TSHR BRAF TERT PMC5720788__F1 Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis FAS INA CP PMC4545213__F4 Mammalian molecular clock and oscillation of mRNA and protein in peripheral tissues PER3 PER2 CRY2 CRY1 FBXL3 PMC8235534__F1 Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update ACLY PCK2 FAS HEL-S-133P F2 HEL-S-162eP PC PCK1 PMC11968292__F3 Keap1-dependent and Keap1-independent regulatory pathways of Nrf2 KEAP1 AHR PMC8035078__F1 LTA synthesis, models for the cross-membrane d-alanine modification process and examples of WTA and complex SCWP synthesis pathways GAL LTA PMC6207586__F6 Mechanism of action of microtitre plate based complement activation assays C6 C7 C9 PMC8397452__F6 Multifaceted Roles of Proline in Cell Behavior LEFTY1 SMAD2 LEFTY2 PKDCC ATF4 PRODH FGF8 PMC3039745__F1 TRAF6 and A20 control K63-linked ubiquitination of Beclin 1 to trigger autophagy TLR4 BCL2 TRAF6 PMC9569951__F1A Roles of Androgens in Humans: Biology, Metabolic Regulation and Health TH SST PMC4292866__F11 Naproxen Induces Type X Collagen Expression in Human Bone-Marrow-Derived Mesenchymal Stem Cells Through the Upregulation of 5-Lipoxygenase COX1 COL10A1 RUNX2 PMC2941735__F2 Targeting Non-Homologous End-Joining Through Epidermal Growth Factor Receptor Inhibition: Rationale and Strategies for Radiosensitization EGF TGFA EGFR PTEN PMC2938833__F2 Actin-cytoskeleton signaling pathway and the candidate genes involved in colorectal cancer progression in patients with ulcerative colitis ABI2 EGF ARHGEF12 F2 ARHGEF1 CD14 ARHA GRB2 BAIAP2 LBP PMC2938833__F3 Pfn gene neighborhood and its interacting pathway VASP PFN3 WASF1 PFN4 PMC6127659__F1 Long non-coding RNAs affect epithelial-mesenchymal transition in gastric cancer cells SUZ12 EED HGF SMAD2 GSK3B EZH2 MMP9 YAP1 WDR5 CTNNB1 PMC4190549__F1 The PI3K/Akt/mTOR pathway BAD FAS PTEN MTOR CCND1 PMC4467582__F7 Proposed schema of the pathways underlying renal protection conferred by xenon (Xe) preconditioning PTEN TNF PMC5362547__F1 Hippo signaling pathway provides novel anti-cancer drug targets LATS1 MOB1A MOBKL1A LATS2 AXL PMC8277576__F5 Steroids on T lymphocytes AIRE FOXP3 PMC9237470__F1 Basal Cell Carcinoma and Hedgehog Pathway Inhibitors: Focus on Immune Response SUFU SHH SMO PMC11800603__F2 Innervation in gliomas promotes tumor growth GRB2 MTOR NLGN3 SRC BDNF PMC9237470__F2 Basal Cell Carcinoma and Hedgehog Pathway Inhibitors: Focus on Immune Response SUFU PTCH1 SMO PMC10967436__F7 ROS modulation of the Keap1-Nrf2-ARE signaling pathway KEAP1 NQO1 MAF PMC11800603__F3 Several example mechanisms of therapeutic avenues of cancer neuroscience: A Inhibit of ADAM10/NLGN3 can suppress glioma growth by targeting its downstream PI3K-mTOR signaling pathway NGF ADAM10 NLGN3 BDNF PMC8481821__F2 Neu Perspectives, Therapies, and Challenges for Metastatic HER2-Positive Breast Cancer EGF NRG1 HBEGF BAD TGFA HIF1A GRB2 MTOR PMC4613661__F1 Model for KSHV v-cyclin-induced dysregulation of Notch signaling during lymphomagenesis CCND3 CDK6 NOTCH3 HES1 PMC3653035__F1 Beta-Catenin plays two main functions in the cell APC LRP5 LRP6 LEF1 CTNNB1 PMC3653035__F2 Wnt ligands induce diverse Wnt pathways MAP1B LRP5 LRP6 RYK RHO LEF1 CTNNB1 PMC3516764__F9 Model for the involvement of the RA in neuronal differentiation FABP5 RARB AJUBA SIRT1 PMC2726781__F1 Retromer sorting pathway is made up of a coat complex that binds and transports transmembrane receptors between the endosome and the trans-Golgi network (TGN) VPS29 VPS35 APP PIGR M6PR PMC3314478__F1 Parkinson’s disease: don’t mess with calcium STIM1 TRPC1 ATF4 MTOR PMC10759737__F6 RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding RPTOR STAT3 SPHK2 YY1 MTOR PMC4721539__F1 Dissecting Germ Cell Metabolism through Network Modeling HEL126 PLB1 CYP26B1 CYP1A2 CES1 LRAT CES3 PID1 PNLIP LDLR LIPE ADFP RETSAT ABCA4 PMC7319280__F7 Systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics OSM ATM MDM2 PMC7369811__F7 Scheme of the potential IR-induced EGFR/NFKB–RIP1–Src–STAT3–EMT pathway STAT3 EGFR SRC PMC7232439__F1 Schematic diagram for activation of innate immune responses and interferon (IFN) signaling pathway after influenza A virus (IAV) infection MAVS NLRP3 TLR3 IRF9 CH25H IRF3 IRF7 TYK2 PMC5075576__F2 Complement-dependent cytotoxicity and inflammation CD59 HEL-S-62p C4B_2 PMC6449645__F1 (A1) GPCRs induce GAq dependent c-Src activation at the plasma membrane and tyrosine phosphorylation of NEDD4-2, releasing NEDD4-2 auto-inhibition MAP3K7IP1 NEDD4 C2 SRC PMC4851164__F3 Network modeling of TGFB signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint Sonic hedgehog and Wnt pathway activation CDC42 FUS CHD1L EGF HGF EGFR GSK3B IGF1R SNAI1 FOXC2 SHH SMO ZEB2 SRC SNAI2 EGR1 HEL-S-28 AXIN2 CD44 IGF1 c-fgr PAK1 SUFU GRB2 TWIST1 PMC4743039__F8 Bidirectional synaptic structural plasticity after chronic cocaine administration occurs through Rap1 small GTPase signaling MAL ARHA MTOR PMC4491987__F6 Effect of the combination of rapamycin and resveratrol on the PI3K/Akt/mTORC1 signaling pathway RHEB TSC2 EIF4B TSC1 IRS1 PMC4851164__F7 Network modeling of TGFB signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint Sonic hedgehog and Wnt pathway activation FUS SNAI1 SUFU GSK3B SHH HEL-S-28 SMO PMC4398700__F3 Ingenuity® Pathways Analysis reveals a possible network of genes activated in IEC-6 cells upon induction of the ephrin-B pathway ATF3 FBN1 CAST SP1 PIM1 JUNB F3 AHR PTGS2 HES1 FOS PMC3156249__F1 B-Myb, Cancer, Senescence, and MicroRNAs E2F4 CDK2 SKP2 PMC4731824__F8 Novel NFKB/YY1/microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis BTRC TRADD RELA IRAK1 YY1 TRAF6 TRAF2 IRAK4 MYD88 PMC3039968__F2 Regulatory Processes Linked to PL Metabolism COX1 COX2 C2 HEL-S-5 PMC11794924__F3 Molecular mechanisms of granulomatous inflammation for sarcoidosis; Antigen-presenting cells, like macrophages and dendritic cells, initiate phagocytosis of antigens STAT3 CXCR3 CCR5 IL33 MTOR TBX21 STAT1 IL16 CCR6 FOXP3 JAK1 CCL20 TYK2 PMC8210588__F5 Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives IPP MVD MVK PMC9661764__F5 ERAlpha-NRF2 signalling axis promotes bicalutamide resistance in prostate cancer CD44 GCLC ERG ABCG2 ABCC2 ABCB1 PMC9197233__F5 Mechanical Strain Induces Transcriptomic Reprogramming of Saphenous Vein Progenitors NR1i1 CDC42 SMAD1 DKFZp781O1323 SMAD2 IRF7 NODAL MAP2 PITX2 MAP2K4 HOXC9 ZNF423 TLX2 BCL2 GSC MAP2K1 GRB2 AMH RNF111 PMC2854141__F9 Uncovering Molecular Biomarkers That Correlate Cognitive Decline with the Changes of Hippocampus' Gene Expression Profiles in Alzheimer's Disease STAT3 FCAR EGF FAS CSF1 TGFB1 LEP RNPC3 EGFR MCL1 GAS NDUFV2 NEFL MYC CSF3 BCR NF1 BMP4 TTN SRC CREB1 MYOD1 JUN ETS2 EGR1 SP1 HEL-S-133P AGTR1 IL4 ARHA TNF NEF3 NEFH CEBPA FOXO1 PRL HEL-S-69p PLCB1 ERBB2 BCL2 PMC7892446__F2 Mechanisms by which SARS-CoV-2 promotes muscle wasting and sarcopenia SMAD2 IGF1R SOCS3 MTOR ACE2 PMC6966687__F3 Networks presenting the functional protein-protein interactions of the (A) 97 down- and (C) 67 upregulated proteins related to the GO term “protein phosphorylation” (GO:0006468) MUSK AURKA LTK MASTL FASTK ABL2 SNRK MTOR TEC LATS2 RICTOR ALK LIPE SMO PMC7352245__F3 Canonical and alternative NFKB signaling pathways CD40 SYK CD79B CD79A LTBR CARD11 RELB TRAF3 BTK BCL10 BCR NFKB1 RELA LYN BIRC2 TRAF2 BIRC3 PMC7759744__F1 Mitochondrial dynamics and bioenergetics in inflammatory astrocytes and neurological disorders CDK5 OPA1 MFN2 PDK2 PMC9495339__F3 Nrf2 in Pulmonary Fibrosis: Molecular Mechanisms and Treatment Approaches MAFK RBX1 MAFG MAFF KEAP1 NQO1 GSK3B PRX PMC7017485__F4 Ingenuity Pathway Analysis showing the plasma membrane and extracellular proteins directly related to YAP1 PATJ MSLN CCDC85C CD36 EGFR SV2B PRRG2 ZYX PIEZO2 MPP7 MPDZ IGF1R NEGR1 SCNN1D DEFA6 TRIP6 CTNNA2 AGRN AMOT APP DMD NF2 HEL-S-52 PIEZO1 THBS1 DAG1 DCC ERBB4 LRP6 PRNP AREG USP9X IGF2 NPPA PARD3 EDN1 PTCH1 BMP2 IGFBP7 VCAM1 PMC7698885__F6 PNPLA3 I148M promotes activation of HH signaling and its downstream target Yap FOXF1 PNPLA3 PFKL AREG HEL-S-30 PMC8750789__F2 AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders CDC42 CACNA1C ST3GAL5 AUTS2 PCGF5 ELMO2 RAC1 MDGA1 PMC10887023__F2 Gene interaction network of dyslexia and stress-associated genes PRMT2 EPB41L3 ROBO1 AKR1B1 MRPL19 KIAA0319 KIAA0319L DYX1C1 TSC22D2 DCDC2 TMEM130 MRGBP C21orf66 MANSC4 CNTN2 PCNT MANSC1 P2RY1 MIB1 RP1L1 TSC22D3 NR3C1 FKBP5 NR3C2 TFIP11 CMIP GPNMB S100B AKAP9 PMC3696556__F4 CD4+ follicular helper T cell infiltration predicts breast cancer survival JUN BATF CD27 LAT AKT3 PAG1 CTLA4 FOS CBL PLCG1 FYN BCL10 CSK NFKBIE BTLA DUSP16 LIME1 SIT1 REL PTPN4 CD6 LCK PMC4529918__F1 An illustration representing microRNAs (miRNAs) and their targets involved in EGFR signaling pathway in lung cancer and anti-EGFR therapy ERF EGFR BRAF PTEN MTOR MYC KRAS PMC3696556__F5 CD4+ follicular helper T cell infiltration predicts breast cancer survival DUSP5 ZAP70 CD80 CRTAM PDCD1 HEL-S-81p HEL-S-62p CD27 LAT STIM1 CARD11 AKT3 IL2RA FYN BCL10 NFKBIE ITK TRAT1 CAMK4 SIT1 PTPN4 CD6 JUN BATF TNFRSF9 PAG1 CTLA4 FOS ICOS GRAP CSK BTLA CD200 REL LCK PMC7290974__F4 Altering host gene expression by disrupting transcriptional regulators PML TRAF6 MYD88 PMC5179328__F3 TLR signaling pathway and ENU-induced mutations that impair TLR-dependent TNF or type I IFN secretion TBK1 SYK LTA TIRAP CD36 MLKL TLR9 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 EIF2AK4 TLR4 TLR7 SLC15A4 RHBDF2 DTNBP1 HCFC2 IRF9 CD14 IRF1 TLR5 IRF3 IRF7 TNF UNC93B1 TLR1 MAP3K7IP1 TLR3 CSK HPS5 PMC11758815__F8 Iron signaling TF CD44 BMP6 MCOLN1 SMAD1 DKFZp781O1323 FES HAMP PCBP1 PMC7290974__F1 Toll-like receptors (TLR) and nucleotide-binding domain and leucine-rich repeat (NLR) receptor signaling in response to L RIPK2 TLR3 IFNAR2 IFNAR1 NOD2 IRF3 IRF7 NOD1 TRAF6 MYD88 PMC11758815__F9 Copper signaling SLC46A3 MT3 CCS PDZD11 HEL-S-67p EGFR SLC25A3 MTOR ATP7B ATP7A ATOX1 CD44 DLAT HEL-S-44 PMC3406594__F8 Schematic model showing role of AMPKA1 as an upstream kinase of TAK1 in TLR4-mediated signaling pathway TLR4 TAB3 MAL IRAK1 TRAF6 TNF MYD88 PMC7900430__F2 Mechanism of the inhibitory role of Wnt/Beta-catenin pathway in preadipocytes during adipogenesis APC GSK3B LRP5 LRP6 CTNNB1 PMC8307089__F1 Intersection of Two Checkpoints: Could Inhibiting the DNA Damage Response Checkpoint Rescue Immune Checkpoint-Refractory Cancer? IFNG TBK1 CD80 HMGB1 ATR FER PMC7829553__F1 Currently known CoA-dependent enzymatic reactions and transporters in human peroxisomes PXMP2 DBP ACOX1 GNPAT CRAT ABCD2 BAAT CROT ABCD3 NUDT7 NUDT19 LBP PMC7829553__F2 Currently known NAD+/NADH- and NADP+/NADPH-dependent peroxisomal enzymatic reactions, transport of NAD+/NADH, NADP+/NADPH, NMNH+, AMP, and 2′,5′-ADP, and role of shuttle systems PEX14 PXMP2 DBP NUDT12 PEX5 LDHB HEL-S-32 HEL-S-26 GPD1 LBP DECR2 PEX13 PMC7829553__F3 Currently known FAD, PLP, ThPP, FMN, and heme-dependent enzymatic reactions in the peroxisomes and transport of FAD, PLP, ThPP, heme, FMN and AMP PEX14 PEX7 NUDT12 HAO1 PEX5 PEX13 PMC8312441__F7 Methylation silencing CDH23 is a poor prognostic marker in diffuse large B-cell lymphoma CKS2 DCHS1 CKS1B CDHR2 CCNE1 E2F4 WEE1 NF2 CCNB1 TFDP2 RDX CDC2 CDH17 PCDH15 E2F2 TFDP1 CDH23 CDH24 CDH26 RBL2 PCDHGA12 PCDHJ CDHR1 PCDHB4 CDH16 PCDHB7 RBL1 CCNE2 PKMYT1 CDKN1A CDKN1B CDK2 PMC2744356__F1 Toll-like receptors in skin infectious and inflammatory diseases TBK1 TLR3 TLR4 TLR9 TLR8 IRAK1 TLR5 IRF3 TLR7 TRAF6 MYD88 PMC5992788__F1 CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease GATC APP PMC5178148__F2 Hypothetical model depicting a potential role of SMAD3 activation in GCT development FOXL2 FOXO1 FOXO3A F3 TGFBR3 PTEN GATA4 TRIB3 TGFBR1 PMC7869020__F1 Purine salvage and de novo purine biosynthesis (DNPB) APRT PAICS PFAS ADSL PMC4310752__F1 Therapeutic targeting of cancers with loss of PTEN function RAD51 PTEN PMC2519122__F1 Role of mTOR in anticancer drug resistance RHEB TSC1 NF1 PTEN GRB2 IRS1 EIF4E PMC4037353__F1 MicroRNA regulation of the germinal center response NCOR2 TH ICOS PHLPP2 GC CCR7 PTEN BCL6 RORA PMC9104602__F5 ZIKV infection downregulates host mRNA expression in the placenta, including genes associated with cellular function and development CD79B OCA2 BANK1 EPO NMU PLA2G2A MHC2TA MAPK8IP1 SOX1 PDGFC MMP3 CNTN2 RAB38 TNFAIP6 H4C9 TNFSF13 CELSR2 OLIG2 TNF PAX6 IRS1 TBR1 MTCL3 ONECUT1 BRS3 UNC93A SSMEM1 ADGRB2 EDN1 ADGRB1 LIN7A NRIP2 KCNN2 LY6G6D ZBTB7C BDNF MPP3 NOBOX SKOR1 RASGRF1 SYT9 SYT17 FOXR2 DNAAF19 LYRM7 LHX5 TNFSF8 INA SERPINI1 CXCL1 KCNK4 POU2AF1 SLC6A3 GRM8 RARB CIDEA AQP4 THBS1 SIM2 NEUROD1 ARG1 ACSS3 HEL-S-92n TDO2 MGP POU5F1 NTRK1 SV2C SYT1 GIPR PMC3864542__F1A What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-kinase Pathway PTEN IRS1 EIF4E PMC8557339__F4 Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis UFC1 C1R FAM3B SFN LYZ CD300C GRN C4A CSF3 HAVCR2 SLAMF7 CA3 YWHAQ HEL-S-1 HEL-S-66 ISG15 C4B_2 HEL2 YWHAG CD209 S100A4 HEL-S-34 PGAM1 MRC1 GFAP HEL-S-69p MB YWHAZ PMC8971730__AF1 CCL18 promotes breast cancer progression by exosomal miR-760 activation of ARF6/Src/PI3K/Akt pathway CCL18 ARF6 SRC PMC3281634__F1 Simplified diagram of the unfolded protein response ATF4 EIF2A XBP1 PMC5288713__F6 Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage NLRC4 NOS2 IL16 PMC7869020__F5 Regulation of de novo Purine Biosynthesis and Purinosome Formation AURKA PAICS ATR PRKCE AURKB ATM HEL-S-70p PFAS ADSL PMC9479340__F1 Tumor accomplice: T cell exhaustion induced by chronic inflammation EGF HGF PMC4497368__F1 The signaling pathway involved in EPO-induced neuroprotection STAT3 BAX EPOR EPO RHO MMP9 PMC4524753__F2 Diagrammatic sketch shows the hypothetical mechanism of HOTAIR in digestive tract cancers ME3 CTNNB1 PMC11821962__F4 WWP1-involved signaling pathways and regulatory mechanisms WWP1 ERBB4 SMAD2 RNF11 BAP1 KLF5 PTEN KLF14 MYC NDFIP1 PMC11821962__F5 WWP1 in different types of human cancers STAT3 MMP21 SMAD2 BAP1 PTEN TCF4 KLF14 MMP9 MTOR VEPH1 MYC NDFIP1 CTNNB1 WWP1 LATS1 LATS2 CDK6 MMP2 KLF5 PMC9630603__F4 Intersection of stem cell biology and engineering towards next generation in vitro models of human fibrosis SMAD2 MSC SMAD4 PMC9486394__F1 Regulation and coordination of the different DNA damage responses in Drosophila CDC2 ATR ATM PMC9486394__F2 Regulation and coordination of the different DNA damage responses in Drosophila OGA CDC2 ATR ATM PMC2901146__F2 Taxol biosynthetic pathway IPP C9 PMC9329401__F7 High protein diet in the induction of sIgA response CCL28 TLR4 PIGR PMC8031259__F2 Insulin signalling pathway and Insulin resistance in COVID-19 and Diabetes infection.Adapted from Jung & Choi (2014), Finucane and Davenport (2020), Rajpal et al TBP IRS1 PMC5130286__F3 Working model RPE IRAK1 VEGFA TRAF6 PMC5923440__F1 MAMP/PAMP sensing pathways in the intestine TBK1 CGAS MAVS TANK SIGIRR IRAK1 IRF3 IRF7 TRAF3 TRAF6 MYD88 CARD8 NLRX1 IL16 NOD2 NOD1 PMC7583738__F1 PTEN in the PI3K/Akt signaling pathway EIF4B GSK3B PTEN CCND1 PMC9386306__F10 Oncogenic circular RNA circ_0007534 contributes to paclitaxel resistance in endometrial cancer by sponging miR-625 and promoting ZEB2 expression ZEB2 TWIST1 PMC5384626__F1 Metabolic pathway of retinoic acid CYP26B1 CYP26C1 ALDH1A3 HEL-S-53e RDH10 ALDH1A2 CYP26A1 DHRS3 PMC3303474__F3 Bibliosphere network of ubiquinol-sensitive genes regulated in liver tissues of C57BL6J mice TF GPAM SP1 ABCA1 PMC7145850__F3 Quantitative results of sphingolipids and enzymes by LC-MRM-MS CERS3 UGCG CERK ACER1 CERS1 SGMS1 CERS2 SPHK1 DEGS1 SMPD1 SGPP2 ASAH2 SPHK2 PMC7572682__F2 Lysosome and nucleus interaction in signaling and transcription NR1C1 FOXO3A CRTC2 TFEB ZKSCAN3 PMC4903173__F1 Foiling IDOL to help control cholesterol PCSK9 HMGCR USP2 LDLR PMC6798117__F9 Model depicting the effects of ZIKV infection on cell cycle progression in hNPCs ATR ATM PMC8112476__F1 Targeting inflammation in atherosclerosis — from experimental insights to the clinic NLRP3 TFPI CCL7 IL1B PMC6729001__F7 Schematic model of METTL3 in regulating CRC METTL3 PMC2783472__F1 Impaired DNA Damage Response – an Achilles’ Heel Sensitizing Cancer to Chemotherapy and Radiotherapy BAX RAD50 MRE11A BRCA1 H2AX ATM MDM2 PMC2783472__F2 Impaired DNA Damage Response – an Achilles’ Heel Sensitizing Cancer to Chemotherapy and Radiotherapy CDC2 BAX ATR BRCA1 PML CDK2 ATM PMC6895606__F1 CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases MECR LIAS PPCS PPCDC COASY PMC6714168__F2 The role and proposed mechanism of Wnt5a in psoriatic arthritis ROR2 RHO PMC10851565__F3 Autophagy’s dual-edge effect on NF-KB and PI resistance SYK TRADD ULK1 RELB OTULIN TAB3 IRAK1 IRAK4 MYD88 ATG12 ATM VCAM1 REL CYLD PMC12023901__F8 ERS-mediated suppression of ERA expression ATF4 XBP1 PMC8268178__F1 Connecting Cholesterol Efflux Factors to Lung Cancer Biology and Therapeutics NPC1 STARD3 PMC5110879__F1 MicroRNAs biogenesis and function DGCR8 AGO2 DROSHA PMC9329261__F2 Elevated CD4+ T Cell Glucose Metabolism in HIV+ Women with Diabetes Mellitus PDHA1 HK3 PDK2 HEL-S-26 MDH1B PMC6418414__F1 The wild-type CARD9 protein consists of an N-terminal caspase activation and recruitment domain (CARD) followed by a coiled-coil domain and a C-terminal tail TRIM62 SYK BCL10 RELB COIL TNF CARD9 PMC7015808__F1 Steroidogenic pathway with oxysterols followed in this study.Abbreviations: CHEH – cholesterol epoxide hydrolase, CH25H – cholesterol 25-hydroxylase, CYP – cytochrome P450, DHCR7 – dehydrocholesterol reductase, ROS – reactive oxygen species CYP7A1 CH25H DHCR7 CYP27A1 PMC3147800__F9 Model showing the cooperative function of LMO7 and Rho in the activation of MRTFs LMO7 LPA RHO PMC8797967__F8 Knockdown of ferritin heavy chain (FTH) inhibits the migration of prostate cancer through reducing S100A4, S100A2, and S100P expression S100A4 ELL S100A2 S100P PMC4589691__F6 Regulatory relationships of a KEGG gene set for the human T cell receptor signaling pathway in RegNetwork TF IL10 JUN CSF2 MAPK13 GSK3B IL4 TNF KRAS FOS CD47 HRAS IFNG FYN BCL10 PAK1 RELA NFKBIA CHUK NRAS LCK CDK4 PMC11853510__F2 Mechanisms of bioactive materials and cytokines in regulating inflammation and maintaining pulp equilibrium through various signaling pathways involving the nucleus [70,71,72,73,74,75,76,77,78] TH TRADD APC IL4 PMC9221615__F9 Endothelial Dysfunction in Acute Hepatic Porphyrias HMBS CPOX FECH UROD UROS PMC3262938__F2 N-glycan biosynthetic pathways in eukaryotes and glycoengineering ALG3 MNS1 PMC10970066__F1 Major components and auxiliary factors of the Notch signaling pathway (modified from ) CCND3 EGF FBXW7 KDM5A EP300 MYC PMC7927147__F1 Development of opto-BMP system BMPR2 SMAD1 DKFZp781O1323 SMAD4 PMC9172199__F3 Comprehensive insight into endothelial progenitor cell-derived extracellular vesicles as a promising candidate for disease treatment CD81 CD9 ARF6 TSG101 CD63 PMC3501016__F1 Finding a New Regulator of the Blood Coagulation Cascade♦ TF TFPI PAK1 PMC10647767__F1 Developments in Genetics: Better Management of Ovarian Cancer Patients FANCD2 RAD51 BRCA1 BRCA2 CHEK2 ATM PMC9324059__F5 Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2 IL10 REN EGFR MTOR VEGFA IRS1 PMC7875638__F4 Network with 11 herbs, 165 active ingredients, 110 intersection targets, and 8 signaling pathways MOS MMP2 HIRA PMC4496101__F1 The extrinsic and intrinsic apoptotic pathway HTRA2 BAX FADD PMC4148637__F1 Relationship between PI3-K–Akt–mTOR signaling and autophagy in muscular dystrophy RHEB TSC2 ATG12 FOXO3A BNIP3 PMC4697333__F5 Reconstruction of TNFAsignaling pathway (target instance) ALPL TRIM32 TXNIP COPE COPS5 SMAD2 FAF1 PEG3 MAPK9 MAPK3 DOK1 MAPK14 RB1 EZR SOST SMARCE1 CRADD GLB1 CREB1 NFKBIZ MCC CASP8 RPSA MAPKAPK2 DERA CRYAA USP11 IRF1 PSMD7 TNF IRS1 PSMD13 ERBB3 RASA3 TSC1 MAP3K1 SOS2 BCL2 MAP2K5 CASP10 DIABLO TBK1 TNFRSF1B NFKB2 TNFRSF1A SPHK1 FBXW11 PPP2CA PRKCB KPNA2 IPO13 RPL18A DPF2 SMARCC2 TXLNA LITAF NUPR2 NSMAF COPB2 AK1 AIMP2 TNIP2 G3BP2 POLR2L COPS4 MUC1 CSRNP2 NKIRAS1 NKIRAS2 MYBPC3 PSMD6 YWHAG RASA4 POLR2C RNF25 HEL-S-101 TBKBP1 RNF31 COPS8 COPA RAC1 LRPPRC MAP3K7IP1 USP2 IKBKB RUVBL2 CREBBP RPL4 CDC37 DDX3X SYK EED FBL NEK2 TRAIP MTIF2 POLR2K PRKCZ TRAF3 SMARCD1 TRAF6 RPS11 TXN BCL2L1 PYGL MOAP1 TRIM28 HSPA2 PRKCA C9 HEL-S-1 CYBA SMARCA4 MADD SMARCC1 ING4 PSMB3 FOS MCM7 RXRA HSPA4 MCM3 ARHGEF1 MCM2 GADD45A CYBB TRADD RASSF1 ARCN1 ITCH EGFR TAB3 IKBKE RELB TANK PML TGIF1 PSMA2 MTOR PSMD2 NCF1 IKBKG TNFRSF8 CKAP2 MYLK PIG59 BTRC RPS13 MAP2K4 PRKCE TICAM1 PRC1 NFKBIE GREM1 SENP2 NOD1 PPM1B ROMO1 HEL2 BAX JUN CASP2 TICAM2 PTPN11 IRS4 RIPK3 PAPOLA SENP1 RPS6KB1 PPP2R1B RELA PIAS1 ARF3 SKP1 MYBBP1A MAP2K1 REL BIRC2 FADD YWHAZ PMC10647767__F4 Developments in Genetics: Better Management of Ovarian Cancer Patients APC RHO CTNNB1 PMC4697333__F6 Cross-talks between TGFBsignaling pathway and TNFAsignaling pathway (target instance) JUND COPE SMAD2 GSK3B SMAD4 FLNA MAPK14 CIDEB FOXO4 E2F3 MAF SOX18 CRADD CREB1 NFKBIZ RNF11 SENP6 ITGB3 YAP1 FNTA PSMD13 ERBB3 TSC1 SOS2 MYCBP2 BCL2 NUP214 STK11 PPIF PGR PMF1 ANAPC11 TNFRSF1A CDC23 CNOT4 RPS6KB2 NR1C2 HEL-S-276 CTCF LITAF NME2 CDKN2C RARB OTUD7B ADAM15 POLR2L MUC1 ACVRL1 MAP2K3 TFDP2 EIF2B1 EWSR1 XPO5 EIF2B2 NEUROD1 RPS27A COPS8 RBL2 VHL NLRP12 PTTG1 RUNX1 SMURF1 CNOT3 USP2 ERBB2 SNX1 FOXA2 CCNK LEF1 SMG1 XPO4 TNFRSF19 UBE2C UPF3B SMG6 TRAIP HECW2 TRAF6 RPS11 HSPA2 PSMB10 HEL-S-1 SRC SMARCA4 ZFP36 HHEX JUNB POLR2F POLR2H MAGOH RUNX3 MSH4 CRK EIF3E ARHGEF1 RNF111 TAF10 RAB6B TANK MEF2C TEAD4 CKAP2 FOXH1 TNFRSF18 GLG1 PRC1 SNX4 GREM1 VPS18 ATM RB1CC1 NKX2-5 VPS36 CITED2 VPS33A SOX2 NCOA1 PARP1 TNPO1 PEG3 TCF4 ATF2 MYC FANCD2 TRAF4 PSMD3 DCP2 FBXW7 CAMK2A SMARCE1 CCNE1 EIF3F ZEB2 RPSA KHSRP IRF7 SKI BCLAF1 HGS SMURF2 BAK1 CASP10 IRF2BP1 TGFB1 SNX6 IPO13 NSMAF COPB2 ROCK1 COPS4 CSRNP2 NKIRAS1 OLIG1 MYBPC3 VPS16 RNF25 HERC1 HEL-S-101 DCAF6 SIK1 BCAP29 PROK1 ARRB2 ANK2 EID2 CITED1 KIF1B BAG4 COPZ2 EXOSC8 XPO7 COPA KTN1 CNDP1 FKBP3 MED31 CNOT1 CCNE2 DYNLRB2 SGA56M MAP3K7IP1 EDF1 POLR3D EIF3J CREBBP SYK SHC1 SPARC ANAPC2 TRIM24 MAP2K6 E2F4 TRIM37 PRKCA CYBA MADD MED15 DYRK2 ANAPC10 ING4 TGFBR3 ATF3 RPE ENG MCM7 BRCA1 HOXA9 MCM3 MCM6 SAMD3 SND1 STRAP CYBB TP73 KLF4 TNFAIP3 ARCN1 BRCA2 RELB MTOR PSMD2 DIS3 EDC3 PAN2 PAN3 KLF10 SENP2 NOD1 HEL2 CASP2 E2F2 TICAM2 SMAD6 HOXA11 DPP3 TGIF2 PITX2 PAPOLA SENP1 ARF3 CASP3 HEL-S-102 SNX2 JAK1 REL YWHAZ PMC10647767__F5 Developments in Genetics: Better Management of Ovarian Cancer Patients CDH2 STAT3 HEL-S-53e MMP2 MMP9 CCND1 CTNNB1 PMC4697333__F3 Reconstruction of Notch signaling pathway (target instance) WDR12 STAT3 SMAD1 DTX1 DTX2 PIK3R2 GSK3B PIK3R1 PRKCZ SKP2 PSEN1 MAPK3 ASCL1 MDM2 SRC HDAC2 HES1 NOTCH1 MAPK1 SIN3A MXD1 MXD4 BLOC1S1 MIB1 MAGEA1 MNT HES6 CNTN1 NOTCH2 FURIN RUNX3 RNF2 TCF3 PRKCQ PSEN2 ADAM10 SNW1 BCOR HEY2 CHAC1 ITCH NUMB YY1 CTNNB1 ADAM17 CHUK JAG2 APP FHL1 LFNG CAMK4 DLL3 MAML2 SPEN JUN DLL4 CCNC RBPJ WWP1 NCOR2 HDAC1 SAP30 MAML1 MFAP2 ARRDC1 EPN1 RELA SYNJ2BP HDAC9 RYBP EP300 ASB2 LEF1 LCK PMC5250669__F7 UPR activation in the spinal cord from an X-ALD mouse model EDEM2 ATF4 EIF2A XBP1 PMC10647767__F6 Developments in Genetics: Better Management of Ovarian Cancer Patients STAT3 HGF MTOR PMC4123468__F7 Reactive Oxygen and Nitrogen Species in Steatotic Hepatocytes: A Molecular Perspective on the Pathophysiology of Ischemia-Reperfusion Injury in the Fatty Liver BAX TRADD TRAF2 FADD PMC4697333__F4 Reconstruction of TGFBsignaling pathway (target instance) DVL1 SKIL JUND RAF1 SOS1 PXN COPS5 PIK3R2 SMAD2 GSK3B SMAD4 TCF4 ATF2 FANCL MYC MAPK3 MAPK14 RB1 CCNE1 FOXO4 MAF MAPK1 NR1i1 SP1 KHSRP SPTBN1 ITGB3 SKI FNTA FOXG1 YAP1 HGS ONECUT1 CDKN1A SMURF2 IRF2BP1 STK11 NUP214 ANAPC7 CNOT4 PPP2CA CDKN2D PROX1 CTCF SUMO1 ROCK1 FKBP1A ACVRL1 OLIG1 MAP2K3 HERC1 EWSR1 SIK1 ARRB2 NEUROD1 EID2 CITED1 RBL2 ARHA AXIN2 ZFYVE16 CNOT1 RBL1 HDAC1 DYNLRB2 RUNX1 SMURF1 CNOT3 MEN1 IKBKB CREBBP SNIP1 EP300 SNX1 VPS39 UBE2I STK11IP LEF1 PJA1 PARD6A SMG1 XPO4 SHC1 SPARC ANAPC2 TRAF6 MAP2K6 STAMBPL1 SRC MED15 ANAPC10 JUNB FOS MAGOH RUNX3 PIAS2 RANBP2 ATF3 CRK ANAPC1 ENG BRCA1 AURKB TAF7 SNW1 CDC27 GRB2 EGR2 PRKAR1B STRAP TP73 ITCH PML TGIF1 MTOR MEF2C CTNNB1 FOXH1 EDC3 BTRC PAN2 PAN3 SNX4 KLF10 CCND1 JUN NCOA1 WWP1 FZR1 ITGB1 NUP153 NFKB1 PPP2R1B PIAS1 SKP1 MAP2K1 PMC7458397__F6 p85 roles (p110 dependent and independent) in the insulin response CDC42 IGF1 GSK3B PTEN IRS1 PMC10647767__F8 Developments in Genetics: Better Management of Ovarian Cancer Patients STAT3 EGF MTOR PMC1774279__F1 Two major intracellular pathways cause apoptosis BCL2 APAF1 PMC9203687__F1 ILC2s in Solid Tumors: Facilitate or Inhibit? CXCL2 CCL5 PMC8495393__F8 FGF7-induced E11 facilitates cell-cell communication through connexin43 CDC42 PDPN FGF7 GRB2 GJA1 PMC6350546__F2 Targets and the simplified downstream effects of their autoantibodies encountered during dermatomyositis MAVS PMC6902895__F2 The biosynthetic pathway for argyrin production in Cystobacter sp ARG1 ARG2 CP PMC5913620__F2 Regulation of Beta-cell autophagy IFNG ULK1 RAG2 RAG1 ATF4 EIF2A ATG5 ULK2 SIRT1 IL1B PMC9570087__F1 Protein Acetylation Going Viral: Implications in Antiviral Immunity and Viral Infection CGAS KAT5 STAT2 IRF9 OTC IRF3 IFI16 IRF7 HDAC3 OTUD3 STAT1 IFNAR2 IFNAR1 HDAC9 ISG15 JAK1 TYK2 SIRT1 HDAC6 PMC4608686__F6 Equivalent Gene Expression Profiles between Glatopa™ and Copaxone® HLA-DMB CXCR3 ICOSLG IL18R1 S100A10 IL27 APC IL2RG CR2 IL2RA CCR3 TNF CXCL10 GATA3 MYD88 IFNG IL18 CCR4 STAT4 IL18RAP IL12B PMC5868363__F11 Possible cellular mechanisms involved in calycopterin-induced apoptosis in HepG2 cells BAX BCL2 APAF1 PMC7396666__F2 Mammalian UPR LOX ATF4 EIF2A XBP1 PMC3742180__F8 Comparison of Cellular Uptake and Inflammatory Response via Toll-Like Receptor 4 to Lipopolysaccharide and Titanium Dioxide Nanoparticles TLR4 CD14 LBP PMC5843858__F4 Diagram showing the possible mechanism involved in the difference between the angiotensin-converting enzyme (ACE) I/D polymorphisms affecting the generation of kinin peptide agonists for B2R and B1R in the downstream variation signaling effects CPM MTOR IRS1 PMC4446516__F1 Complement activation pathways and their regulators MASP1 C6 CD59 C7 MASP2 HEL-S-62p C2 C9 CR2 C4A CR1 PMC4442886__F1 MTOR pathway and its interactions with other important pathways and cellular process relevant to cancer TSC2 TSC1 EGFR CDK2 PTEN MTOR CXCR4 VHL PMC4714670__F4 Cooperation between RasV12 and oncogenic niche cells (ONCs) SCRIB TNF PMC3342401__F7 Summary diagram of the proposed ADM signaling pathway in retina RAMP3 RAMP2 ADM PMC5563468__F5 Regulation of the ROCK/MRTF/SRF pathway in fibroblasts LPA ARHA PMC6941795__F2 Metabolic adaptation and maladaptation in adipose tissue RYR2 CD36 CIDEA PRDM16 UCP1 MCU ATF2 PMC11048169__F1 Main signaling pathways within cancer cells BAX ATR JUN ERBB4 EGFR MCL1 PTEN MAP2 MYC FOS ERBB3 TSC2 CDK6 MAP2K4 MAP3K1 FOXO1 INPP4B BCL2 ATM MDM2 GRB2 CDK4 PMC11048169__F3 Information exchange and signal transmission between cells within the tumor microenvironment ZAP70 ASS1 LAT CCR2 IL4 IL6 NOTCH2 TNF CCL2 XBP1 IFNG ATF4 EIF2A JAK1 NOTCH3 TRAF2 ARG2 NOTCH1 PMC3113807__F5 The Interplay between Protein L-Isoaspartyl Methyltransferase Activity and Insulin-Like Signaling to Extend Lifespan in Caenorhabditis elegans PCM1 SGK1 PMC3613937__F1 Desmoglein-1, differentiation, and disease ERBIN EGF LORICRIN SHOC2 DSG1 GRB2 DSC1 PMC8353812__F10 Characterization and comparative analysis of transcriptional profiles of porcine colostrum and mature milk at different parities TNC MYB LAMA1 CREB5 ITGB4 NGFR PIK3R2 THBS2 COL9A1 JAK3 THBS3 ITGB3 BCL2L11 CSF3 ITGA2B LAMB1 KITLG FGFR2 NGF FGF9 PRKCA COL4A5 IFNA1 PMC10301361__F4 Involvement of the cytoskeleton in the immune response to viral infections TBK1 MAVS IRF3 PMC9666114__F1 MP0274, a Novel DARPin Therapeutic Targeting Human EGFR2 Signaling in Breast Cancer After Prior Trastuzumab and Pertuzumab BAD FOXO3A MTOR PMC2268956__F3 The major pathways leading to apoptosis HTRA2 BAX HEL-S-162eP APAF1 PMC4340657__F1 Modes of cell death NLRP3 MLKL FADD PMC9166799__F5 Secreted ARSs function in cancer YARS FAS GARS1 CXCR1 KARS1 TARS1 CDH6 IL8RB PMC3977891__F2 Interplay between Wnt signaling and other anti-ageing pathways CAMKK2 APC GSK3B MTOR SIRT1 PMC7649144__F1 DHEA is synthesized from pregnenolone through the Δ5pathway (red arrows) thanks the activity of the enzyme CYP17A1 HSD3B2 CYP11A1 STS PMC5141431__F4 Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism NNMT NRK HEL-S-90n NAMPT PMC9208818__F3 Current Status, Opportunities, and Challenges of Exosomes in Oral Cancer Diagnosis and Treatment EGF THBS1 EGFR IL33 CMTM6 COL10A1 PMC3189824__F2 Schematic model for the activation of NFKB signaling pathways CD40 LTBR PTS RELB REL PMC7877337__F3 Virulence factors and related effects in P RAC1 IL1B PMC7471374__F2 Upstream and downstream pathways of CARD9 SYK BCL10 TLR4 IRAK1 TRAF6 TRAF2 IRAK4 CARD9 MYD88 PMC4549066__F1 Activation signals for effector and regulatory T-cell division and proliferation PIM2 JAK3 IL2 PTEN FOXP3 MTOR PMC8146599__F3 Centrosome Dynamics and Its Role in Inflammatory Response and Metastatic Process IL10 ANGPTL4 GDF15 IL6 PMC7973041__F6 m6A methylation plays a critical role in adaptive immunity ICOS YTHDF2 YTHDF1 METTL3 JAK1 VHL PMC7399146__F3 Autophageal mechanism and stages ATG12 ULK1 MTOR ATG5 PMC7399146__F4 Physical exercise actions against aging brain and the apoptotic process BAX NGF FAS BDNF APAF1 FADD PMC9604507__F1 Reversible Platelet Integrin AIIbB3 Activation and Thrombus Instability VWF SYK BTK VASP GC PMC7565641__F5 Innate immune signaling pathways modulating BV transgene expression TBK1 CGAS MAVS IRF3 IRF7 PMC6896028__F1 Nrf2, through its targeted genes, has an anti-carcinogenic role in the case of normal cells and a pro-carcinogenic effect in the case of transformed malignant cells HEL-S-22 HEL107 KEAP1 CDCA4 GCLM PTGR1 KRT16 ABCF2 MMP9 VEGFA ARHA HEL-S-51e CXCL8 SDHB COX2 GCLC PSAT1 ATF4 ABCG2 CYP3A4 HEL-S-44 PMC5515859__F8 Proposed metabolic pathway of F18 in vitro FMO5 HEL-S-25 CYP3A4 PMC5651170__F2 Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications ZAP70 PTPN22 APC LCK PMC6896028__F2 The Nrf2 pathway is regulated at multiple levels by different microRNAs RBX1 KEAP1 PMC7973041__F3 m6A modification participates in innate immunity via regulating the recognitions of unmodified transcribed RNA (tRNA), invading pathogens, exogenous RNAs, and aberrant endogenous double-stranded RNA (dsRNA) MAVS TLR3 RNASEL TLR7 EIF2A PMC7129915__F1 Summary of antiviral signaling pathways in chickens MAVS TIRAP TLR3 IFNAR2 TLR4 IRF9 IFNAR1 IRF7 TLR7 PMC9478308__F6 Research into the mechanism of intervention of SanQi in endometriosis based on network pharmacology and molecular docking technology SYK BAD GAL RBL2 PTEN CD19 MYC RAC1 RHEB TSC2 BRCA1 BCR CD37 MEI1 GRB2 PMC9627214__F2 Necroptosis: A new target for prevention of osteoporosis RIPK3 TRADD MLKL RIPK1 TNF TRAF2 IL1B FADD PMC8263639__F6 Tipping-point for apoptosis following dual inhibition of HER2 signaling network by T-DM1 plus GDC-0980 maximizes anti-tumor efficacy RHEB TSC2 BAD RICTOR TSC1 MCL1 GSK3B BCL2 PTEN GRB2 PMC7471374__F3 Maturation of DCs and IL-1A/B mediated by CARD9 SYK IL1R1 NLRP3 BCL10 PMC5962685__F8 ALA metabolic pathway of cucumber under NaCl stress POR WAS PMC5002062__F1 ClC-Kb/2 expression and function in the distal nephron WNK1 WNK4 SLC4A11 PMC4580658__F1 Schematic diagram showing select signaling pathways in melanoma PTEN GRB2 MYC CDK4 PMC7237829__F1 Endoplasmic Reticulum Stress Signaling in Cancer Cells RTCB ATF4 EIF2A PMC8258675__F1 Mechanisms associated with the depigmentation of brown eggshells: a review CPOX SLC25A5 ABCB6 ABCG2 FECH UROD UROS PMC7576986__F2 Type I IFN signaling and viral countermeasures STAT1 STAT2 IRF9 JAK1 TYK2 PMC6008657__F3 Insulin signaling also controls mTOR pathway that inhibits autophagy ATG12 ULK1 MTOR ATG5 PMC26952__F7 Activation of specific target genes by TGFB and Wnt pathways SMAD4 LEF1 PMC6387036__F2 HBV- and HCC-related genes in L1 biology RAD21 TERT CTNNB1 PMC9425222__F3 DNA Repair Pathway Genes Associated With Ataxia TDP1 RFC4 RFC1 RAD50 RFC2 RAD51 FEN1 PCNA APTX BRCA2 PARP1 PNKP LIG1 MRE11A BRCA1 ATM RFC3 PARP2 PMC2504760__F1 Mechanisms by which diabetes increases cardiovascular disease CD36 VCAM1 TNF PMC2831538__F3 Autophagy regulation in response to stress TSC2 TSC1 ATG12 BNIP3 MTOR EIF2A PMC10137494__F2 Steroid synthesis pathway CYP21A2 CYP11B2 PMC338270__F1 Modification pathway of proteins for isoprenylation/methylation and effects of inhibitors of each enzymatic step ICMT ARHA RCE1 PMC7472700__F3 T-MPs function CD80 CGAS PMC11882765__F1 Ferroptosis Signalling Pathway TF SLC3A2 STEAP3 GPX4 DHFR LPCAT3 FACL4 SLC7A11 PMC7563796__F1 Multiple functions of microglia and macrophages in brain injury MFGE8 CD200 CCL2 PMC7472700__F1 CGAS–STING pathway CSA2 CGAS IFNAR2 IRF9 RELB IRF3 TRAF6 PMC7299722__F1 Effects of doxorubicin on cardiac mitochondrial dynamics and mitochondrial function FIS1 OPA1 MFN2 PMC2816010__F6 Effect of dasatinib on the BCR-ABL signaling pathway CRK EIF4B CBL BCR PTS BCL2 ATF2 SRC MYC GAB2 MEF2C BCLAF1 PMC10671302__F4 Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases CHI3L1 CD44 VEGFA PMC9357805__F2 Microenvironment That Regulates Vascular Wall Stem/Progenitor Cells in Vascular Injury and Repair CDC42 STAT3 CSA2 VAV2 CCR2 IL8RB TNF RAC1 PMC3500853__F3 EphrinB reverse signaling CDC42 PAK1 ARHA RHO PMC6177397__F2 RDGN regulates TGFB signaling transduction in tumor cells.Notes: TGFB binds to TBR and activates SARA, which then recruits and activates intracellular SMAD2/3 protein SIX1 SMAD2 SMAD4 DACH1 PMC5810846__F4 Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics TNK2 PMC7260844__F1 Schematic representation the regulatory networks of lncRNAs in major biology activities during brain developmental process SUZ12 NFIB GSK3B BMP2 OLIG2 ZEB2 BDNF HES1 CTNNB1 PMC8505078__F6 Exploring the Mechanism of Resveratrol in Reducing the Soft Tissue Damage of Osteoarthritis Based on Network Pharmacology and Experimental Pharmacology TES TRO LTA tal-1 MAK PROS1 CD14 APP PMC2634670__F1 Strategies to inhibit the VEGF signalling pathway PIGF DLL4 PMC2577427__F9 Model depicting signaling pathways for TPR-mediated modulation of OLG development and function TPR COX1 RHO PMC5809441__F1 Pleiotropic effects of statins CRP TF PMC11274344__F6 The cancer antioxidant regulation system in therapeutic resistance and scientific questions to be solved MTHFD2 GLS KEAP1 GCLM SLC7A11 ME1 SLC6A9 KRAS ME3 GLUD1 MTHFD1 ME2 GCLC HSF1 HEL-S-26 NADK2 HEL-S-64p NNT HEL-75 PMC7167007__F1 Interferon signaling pathway TBK1 STAT2 IFNAR2 TLR4 IRF9 IFNAR1 IRF3 TYK2 PMC5385290__F2 Folate Nutrition and Blood-Brain Barrier Dysfunction DHFR TYMS MTR PMC10937114__F3 Hypoxia affects adenosine signaling pathways in erythrocytes(A) AMPK-BPGM signaling pathway AMPD3 SPHK1 ADORA2B PMC8307963__F2 Syndromes of Thrombotic Microangiopathy: A Critical Appraisal on Complement Dysregulation HEL-S-62p C9 CD46 C4B_2 PMC8005659__F1 Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3B/Beta-catenin signalling pathway SIRT3 GSDMD NLRP3 GSK3B LRP5 LRP6 RUNX2 AXIN2 IL1B CTNNB1 PMC8139204__F2 CD36 Signaling in Diabetic Cardiomyopathy VAMP2 CD36 VAMP3 VAMP4 IRS1 PMC4205853__F2 Schematic comparing signaling cascades activated by EPO in microglia and macrophages MTOR CTNNB1 PMC8120550__F8 Overexpression of ING3 is associated with attenuation of migration and invasion in breast cancer STAR TNP2 AGER RELA SMO REL PMC6412134__F1 Targeting GBM CSC-mediated chemo/radio resistance by small molecule inhibitors L1CAM EGFR RAD17 SHH ATM SMO ADAM10 ABCG2 CTNNB1 PMC5842951__F1 Rho kinase signaling and cardiac physiology ROCK2 ROCK1 ARHA FHOD3 PMC5810846__F1 Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics APC LRP6 LEF1 CTNNB1 PMC5694448__F6 A model of leptospire-induced apoptosis in macrophages through bid-induced release of AIF/ Endog signaling pathway CASP8 PMC6048953__F2 Insulin action and resistance in obesity and type 2 diabetes RHEB TSC2 TSC1 FOXO1 PMC5810846__F3 Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics RRH PMC9685520__F1 Phase separation drives the formation of biomolecular condensates in the immune system ZMYND8 TBK1 CGAS PMC2100342__F3 Activation of NFKB via the classical and the alternative pathway LTBR RELA RELB VCAM1 REL PMC4813427__F6 Summary of NOP receptor signaling ADRBK1 ARR3 PMC3437536__F1 Class I phosphoinositide-3-kinase (PI3K) signaling pathway BAD FOXO1 PTEN RAC1 PMC5578103__F3 Schematic diagram illustrating the mechanisms of how the estrogen receptor (ER) coordinates with the epidermal growth factor receptor (EGFR) to affect the cell growth in the lung adenocarcinoma EGF EGFR MTOR SRC PMC8544609__F2 Hormetic ER stress signaling elucidated in HSCs TH DDRGK1 ORAI3 STIM2 RUNX1 ORAI1 C2 STIM1 SEL1L ELF2 ATF4 XBP1 PMC2266095__F2 Schematic presentation of the NFKB signaling network in radiation-induced adaptive radioresistance GADD45B ATM SSB PMC11941885__F3 Mechanical stress-related podocyte injury CDC42 CLCF1 EPB41L5 APOL1 TRPC5 ARHA TRPC6 RAC1 PMC2872497__F4 Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment SMAD2 SMAD4 NODAL PMC11941885__F2 Immune-mediated podocyte injury CD80 FH TIRAP HEL-S-62p IRF3 IRF7 CD55 MYD88 PMC8664902__F5 Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis NFATC2 TCN2 PRKCZ MGLL NGF PIGN OPHN1 RC3H1 ARID1B CDH18 MICAL3 MMP2 RPL10 GDAP1 PDE4D ZNF816 CNTN4 KLRD1 FHIT CYLD SMARCA4 ROS1 NOS2 MSRA TBX1 TGFBR3 AREG CLN3 RUNX3 ESRRB RGS6 RAI1 ALG13 LAMA4 DEFA1B ITSN1 DLG2 TNC ADAR GNAO1 STK11 BRD7 TANK PARK2 GRID2 SLIT3 SLC6A3 PRKCE NLRP6 EBI3 WWOX CAMK4 GRIA4 HEL-S-15 CAMTA1 VWF KIF11 TUSC3 ATG16L1 E2F2 CUTA GNE RAB11A PRKDC RELA CREBBP STAT4 TRAF2 PMC8664902__F6 Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis LTBP1 ADORA2A TIRAP GPX4 SSR1 CTSS HIF1A FGF8 SLC23A2 PHLPP1 MSR1 UCN NRAS FLT1 KCNMA1 CABIN1 NBL1 SNAP47 NOTCH1 CDH2 EYA4 FOLR2 CACNA1A HCN2 TBX1 KHSRP FURIN NPC2 FOXO1 RXRA BCL2 SIRT1 NPPC ACLY STK11 HSPG2 TANK PARK2 ZNF7 NR1C2 CD83 CD300A SLIT3 SUMO2 KCNQ3 KCNQ2 NLRP6 EMP2 RRM2 NFATC1 PTPRK HEL-S-70p PTPRS U2AF1 ZBTB16 PMC6263010__F1 Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus DCX GFAP PTCH1 SOX2 PMC10778012__F5 tRF-mediated translational regulation RPS28 JAG2 YBX1 EIF4E PMC6263010__F2 Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus DCX GFAP PTCH1 SOX2 SHH PMC10778012__F1 Oncogenic signaling can drive changes in the transcription of tRNA genes MTOR MYC PMC3058926__F5A Proof of Concept: A review on how network and systems biology approaches aid in the discovery of potent anticancer drug combinations RAP1GAP SAA1 IFNGR1 CETN3 CITED2 PINK1 TXNIP SCD SERPINA3 NBEA CTNNB1 DUSP3 GPX2 NR2A1 OSMR LPIN1 CYP4F3 S100A9 CLDN1 PMC7260686__F5 Herb-target-signaling pathway interaction network MAX VEGFC FZD2 EGFR AKT3 FZD7 TERT VEGFA IL6 MYC FOS TGFBR2 HRAS RB1 HMOX1 CBL BCR PTCH1 BMP4 BMP2 WNT3 GRB2 PMC2628394__F15 Biological network representing the schizophrenia p-value ranking EMX2 SOX9 HLA-F RXRA NR4A3 HIF1A ABCG2 EIF4E PMC3931732__F9 CHC-1 and EPN-1 promote actin polymerization in response to CED-1 signaling MEGF11 MEGF10 EPN1 PMC2628394__F16 Biological network representing the bipolar disorder p-value ranking JUND PDX1 CD74 JUNB WTAP CREM ATF1 NPY HLA-DPB1 ATF4 ATF2 GHR PMC9232097__F7 Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer HEL-S-22 PPARG SYK EPHA2 PGR EGFR JAK3 GSK3B NR1C2 IGF1R CCNA2 MAPK8 PLK1 TGFBR1 MAPK14 TGFBR2 PDPK1 NR3A2 FGFR1 CSNK2A1 IL2 KDR SRC MAPK1 HEL-S-72p NOS2 CTSK PTPN1 KIT PTGS2 ARHA HRAS RHEB HEL-S-130P RXRA CASP3 CDK2 MAPK10 LCK PMC5912970__F2 Genes affecting progression of bacteriophage P22 infection in Salmonella identified by transposon and single gene deletion screens GAL PMC6492940__F4 Essential metabolites PRX HEL-75 ASPA PMC6492940__F5 Inflammation, apoptosis and cell survival BAX STAR GPER APAF1 CTNNB1 PMC3325001__F2 Modes of Hh pathway signaling SUFU PTCH1 SMO PMC9314556__F1 Mitochondrial Epigenetics Regulating Inflammation in Cancer and Aging BAX TBK1 CGAS IRF3 PMC3325001__F1 Hh signaling pathway SUFU PTCH1 SMO PMC7755476__F11 Cell cycle and (b) TGF-beta-signaling pathway regulated by the E2F alteration in brain and CNS cancer AAR2 PCNA ORC6 SMAD2 SMC3 APC CD7 RGMA NODAL ARHA SKP2 ORC2 PITX2 HFE2 BAMBI IFNG RAD21 CDK7 FST BMP2 CDK2 MDM2 CDK4 PMC7576986__F1 IFN-I induction and viral counteracting actions TBK1 TLR3 TLR4 TLR9 TLR8 IRF3 IRF7 TLR7 TRAF6 PMC4380423__F5 Specific Medicinal Plant Polysaccharides Effectively Enhance the Potency of a DC-Based Vaccine against Mouse Mammary Tumor Metastasis TH TREM1 IL10 CD2 CSF2 CSF1 IL6 TNF IL5 CSF3 IL7 IL1B CCL1 PMC11092636__F3 Exercise activates the EGFR/insulin signaling STXBP1 MAP3K12 PRKCZ PTEN MTOR MAP3K14 MAPK14 CA3 HEL-S-42 MAP2K4 INSR PRKCA APP HEL-S-11 SHC3 PTPN11 CRK TSC2 GYS1 RAPGEF1 MAP2K5 MAPK10 SNAP25 MAP2K1 TBC1D4 PMC4437334__F1 Active killing of motoneurons through death receptors under pathological context IFNG IFNGR2 NGF IFNGR1 FAS LTBR FADD PMC5663622__F3 Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials F2 APC RHO CTNNB1 PMC5038604__F4 Protein-protein interaction network of the overlapped DEGs MUC13 HEL114 ACTN1 NEU1 CFTR GLB1 PMC5595906__F4 Results of PPI network analyis RBMX FUS MYB ALPL NRP1 MAPK9 PLK1 MAPK3 BCL2L1 AKAP11 SNRPB SMARCA4 TPT1 URM1 RNF10 TFDP1 USP19 GNB2 WBP11 MRPS7 UCHL5 TBPL1 MRPL14 PSMD7 TAF9 TFAP2B ELP4 LSM6 SET ATF3 RPL23A HMGCR BAG3 MAP3K1 PRPF31 RBM4 PSMC6 ATXN1 DACH1 PPP4C GLI3 MAX RGS12 BCOR HEL113 HELLS PCNA CBX4 BCAM YY1 ACTA2 DCX ADD1 EEF1A1 SSU72 RBM14 CDK4 BAX PRPF3 CCNC CHD3 TFCP2 NR2A1 NR2F2 NFYA TSPYL2 HNRNPC PMC4486731__F3A BRAF gene: From human cancers to developmental syndromes MDM2 GRB2 KRAS CDK4 PMC2781329__F4 Schematic diagram for HO-1 modulation of signaling pathway and adiponectin, EET levels, and vascular function ADIPOR1 ADIPOR2 PMC3218540__F2 Folate metabolic pathway DHFR PMC4421076__F6 Sustained Interleukin-1B Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids BAX IL1R1 PKD1 IL16 IGFBP1 IRF8 IL1B PMC5004238__F4 Schematic illustration of axon-microglia interactions and the CASP6/p38/TNFA signaling pathway in the spinal cord dorsal horn of male rodents CASP6 TRPV1 BDNF PMC6640082__F1 Mammalian Heme Synthesis Pathway HMBS ALAS2 FECH UROD UROS PMC6640082__F2 Heme Synthesis Metabolon HMBS SUCLA2 PGRMC1 ALAS2 FECH UROD UROS CP TMEM14C PMC7464452__F2 Possible endothelial–mesenchymal and epithelial–mesenchymal interactions in BPD-PH FGFR1 SHH FGF10 FGF2 FGFR2 PMC4029965__F7 Predicting Response to Preoperative Chemotherapy Agents by Identifying Drug Action on Modeled MicroRNA Regulation Networks CDADC1 UGCG BUB1B PGR AURKB TTK ERBB2 STK4 PMC8539587__F1 Undercover Agents of Infection: The Stealth Strategies of T4SS-Equipped Bacterial Pathogens NLRP3 AIM2 TLR5 TRAF6 IL1B MYD88 PMC7305518__F5 Graphene induced activation of macrophage signaling pathway (Zhou et al IRAK1 TRAF6 IRAK4 MYD88 PMC4316204__F2 Remodelling the extracellular matrix in development and disease TH MMP14 CDKN1B MMP2 MMP9 MMP11 PMC4316204__F3 Remodelling the extracellular matrix in development and disease BTBD7 MMP14 LOX LRP5 MMP2 MMP3 ARHA FGF10 FGFR2 PMC3375273__F6 TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Osteoclast Differentiation MAP3K7IP1 NFATC1 TRAF6 FADD PMC9219669__F2 Apoptosis and (in) Pain—Potential Clinical Implications BAX CASP9 NGF FAS CASP8 CASP3 BCL2 TNF PMC11012756__F5 Therapeutic Advances and Challenges for the Management of HPV-Associated Oropharyngeal Cancer AURKA FBXW7 WEE1 BRAF FAT1 PTEN MDM2 MTOR PLK1 PIN1 CDK4 CTNNB1 PMC9454904__F2 Current Understanding of Asthma Pathogenesis and Biomarkers HEL-S-92n CXCL5 CXCL1 TNF CXCL8 PMC8371935__F1 Phylogenetic Analysis of Core Melanin Synthesis Genes Provides Novel Insights Into the Molecular Basis of Albinism in Fish MC1R TYRP1 PMEL PMC8549349__F7 ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway ITGB1 TLN1 PMC6322652__F1 mTORC1 and mTORC2 as regulators of cell metabolism in immunity RHEB TSC2 TSC1 SGK1 PDPK1 PTEN PMC2755611__F1 Regulation of aging: does autophagy underlie longevity? RHEB TSC2 TSC1 RAF1 PTEN SIRT2 NRF1 SIRT1 EIF4E PMC5686720__F11 Work model for NLRX1-mediated MAVS degradation during viral infection TBK1 NLRX1 MAVS IRF3 PMC22672__F8 Orb6 kinase is proposed to be part of a regulatory cascade contributing to the mitotic control and responding to the Ras1 and Cdc42-dependent morphological control pathway via the Pak1/Shk1 kinase CDC42 PAK1 WEE1 PMC4646251__F12 The signaling pathways involved in GnRH-induced ERK activation (red arrows) and ErbB4 cleavage (blue arrows) NRG1 HBEGF PKD1 FYN ERBB4 EGFR SRC PMC5555103__F1 Fatty liver diseases are initiated by aberrant hepatic lipid metabolism, and sirtuin 1 (SIRT1) activation plays beneficial effect against the process through inhibiting de novo lipogenesis and increasing fatty acid Beta-oxidation TG FAS NR1C1 ELOVL6 SIRT1 PMC8639500__F4 SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells DUSP5 STAT3 DUSP8 JUN FOSB NFATC2 SOX2 IL6 FOS IL6R STAT1 KLHL21 IL24 SOX9 IL36G BCL2 IL11 IL23A PMC12041846__F6B DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity GNAS COMP PPP1R18 CDK5 PAWR CALY CREBBP CREM ATF1 CAMK4 PMC12041846__F6C DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity ACHE TH NOS2 CHRM5 KEAP1 CHRM1 NGFR CHRNA7 SLC18A3 CHRM3 IL6 TNF SLC5A7 HMOX1 CHRM4 FYN CHRM2 NFE2L2 BCL2 ChAT KCNJ2 PMC12041846__F6A DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity RYR2 JUN GAP43 LEP GSK3B KALRN ARHA HTR2B CD44 HTR1B FOXO1 CASP3 GNA11 MMP3 PC MAP3K5 SRC GNA13 PMC11594113__F1 Insulin-like growth factor 1 signaling pathway BAD MDM2 MTOR PMC3076503__F4 Bioenergenesis neurotransmitter pathways with differentially expressed genes between frontal cortex and hippocampus ACSL3 GAD1 NR1C2 CS NDUFA10 GPX1 COXFA4 ABAT SUCLA2 ACSL6 HK2 DDC NDUFB10 SDHB MIPEP AGXT COX7A2 SLC25A18 ADH6 OGDH UQCRFS1 HEL-S-162eP RXRA ATP6V1E1 ATPAF2 ZNF183 GSTZ1 PPA2 GRB2 NDUFAF1 CPT1A SDHC PMC5764254__F7 Trans10,cis12 conjugated linoleic acid inhibits proliferation and migration of ovarian cancer cells by inducing ER stress, autophagy, and modulation of Src GSK3B ATF4 SRC CTNNB1 PMC5413074__F6 Canonical (NFKB1) pathway requires the NEMO (NFKB essential modulator) complex (IKB kinase A, IKB kinase B, IKB kinase G) to phosphorylate IKB, leading to its degradation CD40 CCL21 IL6 PMC3076503__F5 Bioenergenesis neurotransmitter pathways with differentially expressed genes between frontal cortex and hypothalamus EHHADH PIK3R3 GAD1 NR1C2 CS NDUFA10 COX17 ABAT ALDH2 GPT ECHS1 HK2 DDC NDUFB10 DLAT AGXT SLC25A18 ADH6 UQCRFS1 ATPAF2 ZNF183 GSTZ1 MAP2K2 PPA2 GRB2 GLS2 NDUFS1 PMC7495669__F5 Gene-vocalization links MAGOHB RANGRF NTS SIM1 PPIL3 WBP11 DDC SEMA3A PAX8 TPH2 HEL-S-64p FKBP14 NDNF PMC6003316__F5 Genes of gossypol pathway enzymes and their expressions IPP MVP MVK PMC6355689__F3 Pathway representation for dopamine metabolism TH ALDH2 DRD1 DRD2 SLC6A3 HEL-S-53e SLC18A2 DRD5 DDC DRD3 MAOA PMC5409508__F2 Material Cues as Potent Regulators of Epigenetics and Stem Cell Function RHO MTOR PMC4440595__F2 The BMP/SMAD signaling pathway BMP6 SMAD1 DKFZp781O1323 SMAD4 ID1 PMC10987721__F2 Akkermansia muciniphila: a potential candidate for ameliorating metabolic diseases ICAM2 TG FFAR3 TLR4 FFAR2 PMC3754249__F2 HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations ACLY HEL60 ACO2 HEL-S-133P MAL BNIP3 BNIP3L HEL-S-26 PMC3754249__F3 HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations PGAM1 TKTL2 HEL-S-133P LDHB PMC6685213__F4 Kaposi Sarcoma TBK1 CGAS MAVS TLR9 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR3 IL16 TLR4 TLR8 TLR7 PMC7716495__F1 Activated and inhibited Wnt/Beta-catenin pathway APC GSK3B CTNNB1 PMC8200981__F1 Neutrophil Extracellular Traps in Tumor Metastasis: Pathological Functions and Clinical Applications HMGB1 TLR4 TLR9 HEL-S-28 MMP9 RAC1 CTSC MPO MYD88 PMC7716495__F2 Hallmarks of diverse categories of Wnt/Beta-catenin targeted agents in cancer PORCN DKK1 LRP5 PMC7716495__F3 Graphic overview of Wnt/Beta-catenin signaling pathway targeted interventions in cancer studies COX1 PORCN COX2 C2 GSK3B CTNNB1 PMC8061201__F2 Function of LncRNAs in diabetes-related renal inflammation and fibrosis EGR1 NLRP3 CTNNB1 PMC8848980__F6 Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus FOXN1 KRT71 FOXE1 FREM1 FZD10 HOXC13 THBS3 FRAS1 FREM2 VAV1 CD40LG LTB BTK COL1A1 PTCH2 PTCH1 NOTUM LYN LEF1 DLX3 PMC8848980__F3 Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus CSF2RA HGF LAT PIK3CD CHAD NCF1 PRKCB BAMBI BTK CSF2RB FLT4 CX3CR1 WAS RGS14 COL1A2 SELE NGFR BLNK PIK3AP1 TNF RELN LTB NAIP XB GRAP CHRM2 COL27A1 BMP2 CFTR CD3G PMC6679375__F3 Wnt-EarlyEx tumors show expression of Wnt-associated pathway signatures DVL1 GSK3B SMAD4 MYC PSEN1 BAMBI SOST FZD8 CTBP2 CSNK1E FZD3 CSNK2A2 PORCN DKK1 SRC SOX17 MMP7 FZD2 APC LRP5 LRP6 DVL2 SFRP4 TCF7L2 FZD4 PRKACG RUVBL1 FOSL1 PSEN2 AXIN1 PRKX SFRP5 DKK4 FZD5 FZD10 CHD8 NR1C2 CSNK1A1L APC2 CSNK2B CTNNB1 CCND2 CTBP1 SENP2 DKK2 FZD1 CCND1 NKD1 CCND3 NKD2 FZD7 TCF7L1 AXIN2 SFRP1 CXXC4 CTNNBIP1 FRAT2 CER1 RUVBL2 DVL3 CREBBP EP300 NLK LEF1 WIF1 PMC6913804__F1 Schematic overview of cell death pathways affected by Coxiella burnetii effector proteins BAX BAD PMC10741569__F1 Viruses modulate the EGFR signaling network EGFR VGF RIDA PMC3323522__F7 A Novel 3-Hydroxysteroid Dehydrogenase That Regulates Reproductive Development and Longevity CYP7A1 HSD3B7 CYP27A1 PMC11544528__F5 Mechanisms by which NR4A1 regulates osteoporosis and adipogenesis via the Notch signaling pathway RUNX2 HES1 PMC3877685__F2 Automatic Context-Specific Subnetwork Discovery from Large Interaction Networks HEL-S-62p C2 BRAF CCND1 CTNNB1 PMC4123127__F1 Hippo in the Path to Heart Repair LATS1 LATS2 PMC8618018__F2 Morphophysiological and Proteomic Responses on Plants of Irradiation with Electromagnetic Waves RFWD2 DDB1 FDXR PC ATP6 PMC3529568__F1 TGFB latency, activation and signal transduction SMAD2 SMAD4 ARHA FURIN PMC8275829__F2 ADAMTS Proteases ADAMTS15 ADAMTS14 ADAMTS7 ADAMTS5 ADAMTS9 FURIN ADAMTS20 ADAMTS16 ADAMTS19 ADAMTS17 ADAMTS8 ADAMTS6 ADAMTS12 ADAMTS13 ADAMTS2 PMC2758485__F1 Wnt/PCP signaling and its effects on organogenesis BBS4 CTNNB1 PMC2834542__F5 Actin cytoskeleton signaling pathway as represented by Ingenuity Pathway Analysis CRK ATR ARHA PMC3901886__F1 Schematic representation of ligand-activated AHR signaling AHR AHRR PMC7053300__F5 MiR-17 family miRNAs are predicted to target the p21/CDK/E2F1 pathway to modulate the G1/S transition of the cell cycle under oxidative stress RB1 RBL1 CDK6 CCND2 RBL2 SMAD4 CCND1 CDK4 PMC9647060__F4 Transcriptome and metabolome analyses provide insights into the relevance of pericarp thickness variations in Camellia drupifera and Camellia oleifera CAD RO60 PMC2864141__F1 Models of checkpoint control in (a) S HUS1 CRB2 RAD1 CDS1 RAD17 WEE1 POLE PMC7040013__F4 Pathway analysis reveals predicted gene targets enriched in predominately nervous system signaling pathways for focal (A) or diffuse (B) injury cohorts RALB SOS1 SOS2 CREBBP RRAS GRB2 KRAS PMC4075091__F5 Domain structure of p62 and its interacting partners NBR1 KEAP1 TRAF6 PMC8185227__F3 LncRNAs in the Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma STAT3 EGR1 FOXK1 LRP6 PTEN MTOR CTNNB1 CDK8 PTTG1 BMP1 DKK1 MYBBP1A FOXA2 PMC12221920__F3 Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration LATS1 LATS2 NFATC2 LOXL1 MPDZ SCRIB AJUBA PMC12221920__F4 Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration LATS1 DKK3 MOB2 TIAM1 LRCH4 HSF1 MTOR SRC PMC12221920__F1 Two states of the Hippo pathway in the mammalian tumor microenvironment LATS1 MOB2 PMC5036969__F3 Mitochondria and Cancer PTEN YY1 MTOR PMC10374481__F7 HAMLET effect on cell death and mitochondrial respiration in colorectal cancer cell lines with KRAS/BRAF mutations BAX EGFR APAF1 BIRC3 PMC2834616__F4 EGR3 and miRNAs involving in signaling pathways and regulatory networks in schizophrenia and nervous system NRG1 NGF EGR1 DRD2 NGFR GAD1 BCL2 NPY ARC GABRA4 BDNF PMC5008272__F7 Monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model DKK1 APC GSK3B LRP5 PMC6612409__F2 Intestinal disease-related pathway including MAPK signaling pathway, NF-kappa B signaling pathway, calcium signaling pathway, and chemokine signaling pathway PLN BDKRB1 RAF1 TRADD TNFRSF1A IRAK1 NTSR1 HTR2A CS TRAF6 IRAK4 PRKCB MYD88 F2R TLR4 IL18 SRC IL1B NOS2 CD14 PTGS2 TNF CXCR1 PTGER1 RELA EDNRA HEL-S-102 TRAF5 LBP TRAF2 PMC9585326__F1 Mitochondria-associated endoplasmic reticulum membranes in insulin sensitivity, energy metabolism, and contraction of skeletal muscle INSR TLR4 PPA2 IRS1 PMC6878846__F1 Hereditary systemic autoinflammatory diseases and Schnitzler’s syndrome MAP3K7IP1 TRADD OTULIN IRAK1 RIPK1 TRAF6 TNF TRAF2 IRAK4 MYD88 PMC9024452__F6 Restricted Activation of the NFKB Pathway in Individuals with Latent Tuberculosis Infection after HIF-1A Blockade VIT CYP27B1 IL18 PMC6977016__F3 Role and mechanisms of frequently-studied traditional herbs in treating NAFLD FXR1 NLRP3 SIRT1 MYD88 PMC3266662__F3 Correlations of genes in central carbon metabolism with SPPR RPE EN2 tal-1 ENO2 HEL-S-68p LAT MAL EN1 GIP ENO1 CIT PMC7966921__F3 Myristoylation in regulating TRIF-related adaptor molecule (TRAM) during LPS-induced TLR4 inflammatory responses TLR4 MAL IRF3 MYD88 PMC8490662__F8 Macrophage-Mediated Bone Formation in Scaffolds Modified With MSC-Derived Extracellular Matrix Is Dependent on the Migration Inhibitory Factor Signaling Pathway CD44 CD74 OSM MSC MIF FGF2 PMC8968907__F4 Mitochondrial anti-apoptotic dependencies of hematologic malignancies: from disease biology to advances in precision medicine CD44 CD40 BAX CXCL12 MCL1 BCL2 PTPN11 CXCR4 KRAS PMC3984536__F3 HCV life cycle and points of intervention TG EGF CD81 DGAT1 EPHA2 NPC1L1 EGFR APOE LDLR APOB CLDN1 PMC6096387__F8 Proposed mechanism of JuA-mediated AB clearance ABCG1 CD36 APOE ABCA1 PMC8778593__F2 Therapeutic implications of exosomes in the treatment of radiation injury TGFBR2 LATS2 TRAF6 MMP11 NOTCH1 PMC5770815__F1 Kynurenic acid (KYNA) synthesis along the kynurenine pathway and its mode of action KYNU AHR IDO2 PMC5770815__F2 Kynurenic acid (KYNA)-mediated pathways of inflammatory signaling ARRB2 IL4 IRF1 AHR IL6 SRC TNF CTNNB1 PMC6316386__F1 Transient receptor potential (TRP) channels and itch signaling HTR2B LPA S1PR3 HTR7 TSLP TRPA1 TRPV3 TRPC4 TRPV1 TRPM8 PMC8954173__F1 Genetic Landscape of Peripheral T-Cell Lymphoma ZAP70 STAT3 LAT JAK3 ITK VAV1 RHO GRB2 JAK1 TYK2 LCK CTNNB1 PMC6774191__F6 ERKI/II (MAPK) can serve as a convergence site for multiple extracellular signals known to induce plasticity in mature neurons SOS1 GRB2 SRC PMC4881570__F2 MiRNAs in cardiac fibrosis pathway STAT3 SMAD2 IL6 RHO JAK1 COL3A1 SPRY1 FOS PMC6920353__F4 Blood transcriptome profile induced by an efficacious vaccine formulated with salivary antigens from cattle ticks CXCR3 CIC SIN3A SP1 STAT2 EGFR IRF9 CCR2 TLR9 AGTR1 EPO STAT1 IFNGR2 AGTR2 ENO3 SSTR2 C2 BCAN ZNF217 AHNAK RASD2 CCR1 BDKRB2 PMC9185618__F2 Targeting the methionine addiction of cancer HEL-S-182mP MTAP HEL-S-61p PMC4498940__F3 Changes in the pRb and p53 pathway promoting cell cycle passage in high-grade central chondrosarcoma, as found in the present and previous studies MDM2 CCND1 CDK4 PMC5390360__F4 Interaction between AMPK and AKT on the phosphorylation: Growth factor activates TKR and promotes the activation of AKT via IRS1/PI3K/PDK1 signaling PTEN IRS1 PMC4881570__F3 MiRNAs in cardiomyocyte apoptosis pathway STAT3 CASP9 GSK3B BNIP3 PTEN HIF1A MTOR ARHA TNF MYC PRKCE ROCK1 CASP3 BCL2 MCU JAK1 APAF1 CCND1 UNK PMC5758710__F1 G10’s modified pathway diagram for the alfalfa lignin system CAD CCR2 CCR1 PMC5390360__F2 ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway TG TSC2 EIF4B BAD HK2 GSK3B BCL2 MDM2 MTOR ULK2 EIF4E PMC5390360__F3 ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway RHEB TSC2 EIF4B TSC1 ULK1 PMC5805998__F3 Functional enrichment of combined differentially expressed gene list in severe asthma across all tissues KLF4 TF JUN CD14 SNCA PTGS2 CS ITGAX CCL2 SPI1 MAPK6 RHEB RALA RELA HEL110 CCL4 PMC8211286__F1 Schematic presentation of IL-6/JAK/STAT3 pathway in pancreatic cancer cells and tumor microenvironment STAT3 KRAS PMC8523922__F2 IL-36 in the Pathophysiological Processes of Autoimmune Diseases IL4 IL2 MYD88 PMC7049637__F2 Proposed mechanisms involved in the anti-fibrotic activity of curcumin by inhibiting the activation of PSCs to acquire myofibroblast-like phenotypes ACTA2 IL16 IL6 PMC7049637__F3 Proposed mechanisms involved in the anti-fibrotic activity of rhein CDH2 STAT3 EGFR SHH PMC3348440__F1 Target-derived NGF mediates axon growth and synapse assembly in sympathetic neurons via endocytic signaling mechanisms NGF PMC4105941__F1 The Self-Limiting Dynamics of TGFB Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation SMAD2 SMAD4 SMURF2 PMC2134838__F2 ALTERNATE ROUTES FOR DRUG DELIVERY TO THE CELL INTERIOR VTI1A VAMP3 YKT6 VAMP4 PMC8812242__F6 Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction TH MAL TOB2 AGA PMC8612001__F3 Epigenetic modifications in thymic epithelial cells: an evolutionary perspective for thymus atrophy WNT5B CDH2 SMAD2 WNT4 PMC8898354__F1 Crosstalk between adipose tissue and the microbiota-gut-brain axis in metabolic diseases CCK PYY ARC PMC8507396__F2 PLCG1 in regulation of VEGFR2 and FGFR1 signaling PLCG1 FRS2 FGFR1 GRB2 PMC8898354__F3 Crosstalk between adipose tissue and the microbiota-gut-brain axis in metabolic diseases LEPR ARC PMC9496810__F7 White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy APC LRP5 LRP6 CTNNB1 PMC5770468__F8 Model depicting the suggested signaling pathway modulated by CSs to inhibit HIV-1 gene expression EGFR MAPKAPK2 CS GRB2 SRC PMC4132214__F1 Transcriptomic differences between OVCAR3 and SKOV3 and PCA after interaction with the mesenchymal cells SNAI2 NRP1 SHOX2 TSC22D3 RUNX2 ERBB3 CDKN2A DKK1 EDN1 CEBPD PC ERBB2 BDNF TWIST1 PMC2774854__F1 Schematic overview about TCR-dependent signalling pathways CDC42 ORAI3 FYN ORAI1 LAT STIM1 IL2 GRB2 LCK PMC4132214__F2 Pathways modified in OCC upon MSC contact related to adherence, migration, and invasion OGT VAV3 TXNIP VEGFA DKK3 ATF3 POSTN MAP3K8 NID1 CDH11 DIPLA1 HAS3 MMP3 SULF1 BDNF PMC8140999__F5 Translational control by eIF2A phosphorylation ELF2 EIF2A PMC8523993__F8 Performance Assessment of the Network Reconstruction Approaches on Various Interactomes PIK3CA MMP12 PIK3CD PIK3R2 PIK3C2A PIK3R1 PRKCZ MAPK3 FGFR2 LPA RB1 PIK3C2B CDK6 CCNE1 FOXO4 MAP2K6 NF1 PDPK1 PRKCA NRAS SRC MAPK1 MSH6 HRAS ERBB3 TSC2 PRKCI TSC1 BRCA1 PRKCQ FBLN5 FOXO1 CDK2 MAP2K5 GRB2 EGFR BRCA2 IGF1R PRKCH PRKCB MAP2K4 APOH ATM APP CDK4 KRAS SPRY2 CBL FOXO3A ERBB2 EP300 MAP2K1 MAP2K2 PMC4586477__F2 TAA-specific CD8+ T cells often lack co-stimulation for an immune response against tumors CDC42 ZAP70 SYK CD80 FYN LAT PAK1 CSK ITK VAV1 GRB2 FOS PMC11087724__F1 AMPK/mTOR signaling pathway involved in regulation of feed intake in chickens (created with BioRender RHEB TSC2 TSC1 MTOR PMC11087724__F2 Leptin and insulin signaling pathways in the hypothalamus of chickens regulating neuropeptide genes (created with BioRender STAT3 FOXO1 POMC NPY SOCS3 IRS1 PMC11087724__F3 Detailed leptin signaling pathway in the hypothalamus of chickens (adapted from “Cytokine Signaling through the JAK-STAT Pathway”, by BioRender STAT3 NPY SOCS3 PMC4586477__F5 Many signals overlap with PI3K/AKT/mTOR pathways in tumor-specific CD8+ T cells RHEB TSC2 BAD TSC1 HEL-S-28 PTEN CDC37 MDM2 GRB2 EIF4E PMC7905169__F3 Regulation of NF-kB activation by ubiquitin ligases and DUBs TAB3 TRAF6 CYLD PMC6097464__F11 TGF-beta signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set MAPK1 THBS1 ROCK2 SP1 SMAD2 THBS2 THBS3 TNF MYC TGFBR1 TGFBR2 IFNG RBX1 INHBB INHBA ACVR1 FST SKP1 SMURF2 PMC7905169__F4 The regulation of TGFB pathway by ubiquitin ligases and DUBs WWP1 SMURF1 USP15 SMAD2 USP11 SMAD4 SMURF2 PMC7230639__F1 Mechanisms of lactate-BDNF interaction following physical exercise FNDC5 HCAR1 BDNF SIRT1 PMC6097464__F10 MAPK signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set PURA CRK ARHH BAD SHC4 PAF1 FER CRKL HEL-S-28 PTEN VEGFA SHE PMC6303891__F7 Putative mechanism is demonstrating how the loss of SEMA5A can trigger EMT GSK3B SEMA5A CTNNB1 PMC3896784__F8 Model of FTO regulation of leptin action and glucose homeostasis through the LepRb-STAT3 signaling pathway STAT3 LEPR SOCS3 PMC5603666__F10 Graphic representation of pathways for furanodiene-induced cell apoptosis and for doxorubicin-resistant MCF-7 cells outcomes BAX BAD HEL-S-11 PMC7807149__F6 Lycopene Production Pathway in Triple KOE RPE PC GOPC PMC10999658__F7 Molecular mechanism underlying CE accumulation in ccRCC and suppression of cancer progression upon CE depletion SOAT1 MTOR VHL PMC6778377__F6 Schematic illustrating how Nrf-2 activation regulates phenotypic modulation KEAP1 GCLC HEL-S-44 PMC4388604__F1 WDFY1, a new player in the TLR-TRIF pathwayTLR3-stimulated signaling is fully dependent on TRIF, and TLR4 stimulates two signaling pathways, one of which is dependent on TRIF TLR3 TLR4 PMC3695741__F2 Nicotine and Pathological Angiogenesis BAD TRPC4 TRPC1 TRPC5 PMC3764071__F1 One-carbon metabolism and glutathione (GSH) synthesis and metabolism INA HEL-S-61p MTR PMC8482636__F7 Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer INMT SMYD3 MSC PMC4313732__F2 Cytosolic nucleic acid pattern recognition and activation of ISGs STAT1 CGAS MAVS USP18 CH25H RNASEL AIM2 IRF1 IFI16 IRF3 IRF7 RAC1 PMC8434532__F4 Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer ATF4 EIF2A XBP1 PMC6695817__F1 Mitochondrial antiviral signaling protein (MAVS)-dependent antiviral signaling pathway IFNLR1 MAVS IFNAR2 IRF1 IRF3 PMC5380511__F7 A genome-wide loss-of-function screen identifies SLC26A2 as a novel mediator of TRAIL resistance CDC42 STAT3 PIK3CA TGFA RAF1 SOS1 PIK3R3 BRCA2 SMAD2 GSK3B PIK3R1 SMAD4 MAPK9 MAPK8 NCK2 TGFBR1 TGFBR2 RB1 STAT1 RALB CDK6 RALA MAP2K4 E2F3 PRKCA CHUK RALBP1 CDK4 MAPK1 CASP9 RAD51 NCK1 KRAS RAC1 CBL MOS CAMK2D NFKB1 SOS2 MAPK10 JAK1 MAP2K1 GRB2 PMC6115922__F1 Honey Bee Immune Pathways—Highlighting Genes Implicated in Antiviral Immune Responses AGO2 UNC80 FADD PMC4746893__F1 Cyclin D/cyclin-dependent kinase (CDK)4/6/retinoblastoma (Rb) Pathway and the cell cycle CDC2 CDK6 CDK2 CCND1 CDK4 PMC6972667__F4 Linking the protein C pathway with EPCR‐ and ICAM‐1‐binding IEs in cerebral malaria VWF APC MMP9 PMC8140811__F7 Protein Signature Predicts Response to Neoadjuvant Treatment With Chemotherapy and Bevacizumab in HER2-Negative Breast Cancers SYK CXCL12 EGFR NRP1 ACACA VEGFA ANGPT2 TP53BP1 ANGPT1 MYH9 CHEK1 BCL2 KDR CXCR4 NOTCH1 PMC6294046__F4 Druggable proteome across five classic cancer pathways HRAS PIK3CA EGF ALK EGFR BRAF NRAS KIT PTEN MTOR KRAS HEL-S-26 PMC5337876__F10 Schematic diagram depicting proposed mechanism for the Wnt signaling pathway activation during differentiation of ADSCs into insulin-producing cells LRP5 LRP6 CTNNB1 PMC8913504__F3 Metabolism Characteristics of Th17 and Regulatory T Cells in Autoimmune Diseases IL2RB IL2RA FOXP3 MTOR JAK1 PMC6404501__F2 Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/ reperfusion injury RHEB MTOR PMC2831127__F7 Proteins Secreted By Embryonic Stem Cells Activate Cardiomyocytes Through Ligand Binding Pathways STAT3 HGF ROCK2 JUNB IGFBP1 ERBB2 IGFBP2 ARHA MIF RAC1 FOS MEF2D PMC7760417__F1 Virus entry initiates the interferon (IFN) response IFNLR1 MAL IFNAR1 IRF3 TYK2 MYD88 PMC3678388__F1 Canonical ATR signaling pathway and functions of newly identified regulators.(A) ATR signaling is activated in response to single-stranded DNA gaps in the genome CEP164 TOPBP1 ATR ATRIP BACH1 CDC6 FANCM FAAP24 MCM6 MCM2 CINP CDC5L PMC8324723__F1 Forecasting early onset diminished ovarian reserve for young reproductive age women BGLAP STAT3 SLPI PGR BAG1 TSG101 SUMO1 PRL RELA ADRB2 POMC CD163 TBP SRA1 PMC3678388__F3 ATR recruitment to some DNA base lesions proceeds through a mismatch repair-dependent mechanism.Mismatch repair proteins may contribute directly and indirectly to ATR recognition of some times of DNA damage TOPBP1 ATR ATRIP PMC8156839__F1 Survey of Bacterial Microcompartment Distribution in the Human Microbiome GRM3 GRM4 GRM6 GRM2 PMC6002666__F4 Predicted models for central metabolisms of A OMP AMT PMC9021375__F8 Lysophosphatidic Acid Receptor 3 Suppress Neutrophil Extracellular Traps Production and Thrombosis During Sepsis LPA TLR4 CD14 MYD88 PMC9475012__F1 Neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review ATG3 CDK5 BACE1 EIF2A BDNF IRS1 CTNNB1 PMC7780227__F1 MAPK pathway: activators and inhibitors CDC42 ATF2 RHO PMC2975271__F9 Schematic model for regulation of mTOR pathway signaling through interaction of the p53 target Plk2 with TSC proteins TSC2 TSC1 PLK2 MTOR PMC8705144__F3 Hippo Pathway in Regulating Drug Resistance of Glioblastoma LATS1 LATS2 NF2 PRCC PMC5120213__F1 Schematic model of the three apoptosis signaling pathways BAX CASP9 ATR CASP8 CASP3 MSC CASP10 PMC8705144__F1 Hippo Pathway in Regulating Drug Resistance of Glioblastoma LATS1 LATS2 NF2 PMC9630567__F1 Involvement of endoplasmic reticulum stress in rifampicin-induced liver injury KEAP1 ATF4 XBP1 PMC9613996__F5 Hypothesis of how loss of Gamma-secretase function causes ferroptotic stress LRP8 MAML1 GPX4 SEPHS2 SELENOP NOTCH1 PMC8236109__F1 Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net HDAC1 FOXM1 SP1 BRCA1 CDC6 EGFR BRCA2 PMC3425078__F5 Effects of NO and nitrosative stress on apoptosis FAS APAF1 PMC8236109__F2 Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net FOXM1 BRCA1 CDC6 EGFR BRCA2 CCND1 PMC2596245__F3 EET- or sEHI-mediated antihyperalgesia occurs through 2 distinct mechanisms TES LOX PBR PMC2882520__F3 Disease associations in the hypothalamus (genes regulated at p<0.001; fold change > ±1.5) SLC12A3 GFER MED28 TOPBP1 HEL-S-19 PNMT C1S C1QBP INS SLC4A1 MYLK PELP1 NR3A2 PRC1 PC FES MCM2 CCNB1 BIRC2 CREB1 PMC83988__F10 Signaling pathways for NFKB activation by IL-1B CDC42 TRAF6 RAC1 MYD88 PMC2570606__F6 Proposed model for the effects of hypoxia-induced energy stress on them TOR pathway in HNSCC cells RHEB TSC2 TSC1 MTOR PMC5904076__F2 HSPs and the DNA damage response (DDR) ATR ATRIP H2AX HSF1 HEL-S-102 ATM PMC7930050__F7 GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia CDK6 CDK4 PMC7563617__F5 Metformin-induced CSC suppression through AMPK activation and inhibition of protein prenylation by suppression of the mevalonate pathway GGPS1 IPP HMGCR SQLE FDPS RHO MTOR PMC10857240__F1 Proteins and genes involved in chlorophyll synthesis pathway POR HMBS CPOX MGP UROD UROS PMC4200333__F9 Signaling pathways involved in TC adhesion-induced ICAM-1 expression on ECs under flow chamber conditions CD44 SP1 PMC6047913__F6 Enriched target genes of the TFs TCF7, RUNX1, STAT3, and SOX4 in the MAPK signaling pathway ECSIT MPL JUN FAS MOS NF1 CD14 DAO FLNA PMC11940265__F6 Arachidonic acid metabolism pathway, with genes detected in ovary and testis transcriptomes LTB PGC LTA HEL110 ALOX12 PMC4183126__F2 PALB2 links BRCA1 and BRCA2 into a pathway of products of breast cancer susceptibility genes RAD51 BRCA1 BRCA2 PALB2 PMC5904076__F6 HSPs and double strand break repair POLL RAD51 LIG1 PCNA BRCA1 HSF1 BRCA2 HEL-S-102 POLI PMC2765790__F7 Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes NAMPT SIRT1 PMC11940265__F5 Oocyte meiosis signaling pathway, with genes detected in ovary and testis transcriptomes POR CD2 REC8 STAG3 IGF1 MOS C2 SMC3 CDK2 MYT1 PLK1 INS PMC11958968__F3 Network representation of DSF, its modulated targets, and pathways involved in RF TNLG1B CYP2E1 CTSH PIK3R1 HSD17B10 PTEN HTR2A PTGS2 MMP9 MTOR TNF PLA2G2A ALDH2 FTL ALOX5 NLRP3 CDKN1A FOXO3A RIPK1 PIGS THPO PMC12003521__F2 Mouse LrNK cells in other liver diseases (except for liver viral infection and liver cancer) CXCR3 CGAS IL33 CXCL10 TNF PMC11958968__F5 Cluster analysis for DSF-modulated targets GUSB CYP2E1 MGST1 CR2 MMP9 TNF ALDH2 ALOX5 ITGB8 NQO1 PTGS1 CCR7 MMP2 VCAM1 CXCR4 CYP3A4 CCR1 HEL-S-44 PMC3400941__F1 Model depicting PI3K signaling BAD PTEN MTOR IRS1 PMC9654827__F8 Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma SNCB SNCA PMC5051518__F1 Simplified diagram of the adaptive and apoptotic pathways of ERS BAX ATF4 EIF2A XBP1 PMC11628441__F1 MTOR signaling pathway in astrocytes (simplified scheme) RHEB TSC2 TSC1 INSR HABP2 PTEN PMC5540209__F1 PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression IGF1R GRB2 IRS1 PMC4698658__F1 Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers CD36 FASN LIPE CPT1C HIF1A TIGAR SCO2 MTOR MGLL MYC IMPACT PMC6594283__F7 Possible signaling transduction pathways induced by SIRT7 in LPS-treated DCMECs BAX SIRT7 MAP3K7IP1 IL16 TLR4 PMC3667869__F1 Resistance to EGFR targeted therapies AXL EGFR PTEN PMC5054714__F2 DEGs in cell cycle pathway Up-regulated and down-regulated DEGs are highlighted in red and green, respectively CCND3 ATR TGFB1 PCNA TFDP1 SMAD4 CCNA2 MAD2L1 CCNH CCNB3 PTTG2 RB1 RBL1 CCNE2 PRKDC CHEK2 CDK2 UBE2F YWHAG PMC7463613__F2 Notch signaling pathway in cancerogenic events NOTCH2 NOTCH3 NOTCH1 PMC11202427__F1 BMP pathway in cardiomyocyte differentiation SMAD1 DKFZp781O1323 ISL1 SMAD4 PMC3035565__F11 WNKs: atypical protein kinases with pleiotropic actions WNK1 WNK2 WNK4 PAK1 ARHA RAC1 PMC11202427__F2 WNT signaling pathway APC GSK3B CTNNB1 PMC5054714__F1 DEGs in p53 signaling pathway Up-regulated and down-regulated genes are color-coded in red and green, respectively ATR BAD CDK2 PTEN UST PMC8418611__F4 Several signaling pathways regulated by circRNAs in osteoporosis SMAD1 TRADD SMAD2 APC GSK3B LRP5 SMAD6 SMAD4 LRP6 RUNX2 CTNNB1 SMURF1 BMP2 SMURF2 TRAF2 PMC6781400__F7 Schematic illustration of the role of CyclinD1 to regulate Dicer promoter in ICC CDK6 CCND1 CDK4 PMC4641790__F8 Mammalian target of rapamycin complex 1 (mTORC1) is required for mouse spermatogonial differentiation in vivo SOHLH2 RARA NR1B3 SOHLH1 EIF4EBP1 RPS6KB1 PDPK1 KIT PMC7541099__F3 Putative mechanisms of SARS-CoV-2 infection TMPRSS2 TLR7 MMP9 FURIN ACE2 MYD88 PMC8999129__F3 Novel Insights into Autophagy and Prostate Cancer: A Comprehensive Review STAT3 EGFR PTEN MTOR CTNNB1 PMC317204__F8 Schematic diagram illustrating a model for the antagonistic roles of Dp110 and DPTEN in Drosophila growth control IRS4 IRS1 PMC7541099__F2 Therapeutics under clinical trials targeting the cytokine storm in SARS-CoV-2 infection CRP STAT3 ADAM17 HEL-S-62p MAK MSC TPO SOCS3 MMP9 ACE2 MYD88 PMC9141180__F2 Soyasapogenol C from Fermented Soybean (Glycine Max) Acting as a Novel AMPK/PPARA Dual Activator Ameliorates Hepatic Steatosis: A Novel SANDA Methodology AURKA SYK PRKD1 TYMS FAAH MAPK14 PYGL PSENEN DRD2 SPHK2 PIM3 NPC1L1 GC F10 ITK HEL-S-11 MDM2 POLE HEL-S-26 BCHE ABCB1 EPHX2 NR1i1 PDE10A SCD CTSL GRM2 FNTA HMGCR AURKB PSEN2 CYP2C9 CDK2 CA4 PGR EGFR AKT3 SPHK1 BRAF NR1C2 TERT PRKCH OPRK1 SHBG F2R CNR2 TTK CHUK CNR1 APP CCND1 ACHE NR1H3 PTPN1 FABP4 CYP1A1 CRHR1 S1PR1 RORC NR1C1 MALL IKBKB INCENP PTPRE PMC11668946__F1 Ferroptosis in ischemic stroke: Animal models and mechanisms SLC3A2 GPX4 LPCAT3 FACL4 ALOX15 APP SLC7A11 HEL-S-64p PLAA PMC11668946__F3 AA participates in the deacylation/reacylation cycle of membrane phospholipidscPLA2A cleaves glycerophospholipid molecules at the sn-2 position to produce AA LOX LPCAT3 FACL4 PMC7680860__F2 Synthetic CO2 fixation pathways for acetyl-CoA synthesis HEL107 RPE PMC3085878__F3 TLR-induced microbial resistance TBK1 TANK TLR9 CD14 IRAK1 IRF1 TLR5 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 TLR1 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC7599540__F4 Src Homology Region 2 Domain-Containing Phosphatase-2 (SHP-2) targeting on melanoma cells EGF HGF PMC5297719__F1 Molecular Biomarkers for Prediction of Targeted Therapy Response in Metastatic Breast Cancer: Trick or Treat? GSK3A GSK3B PTEN IGF1R SRC PMC3356073__F1 Phosphatidylinositol 3-kinase (PI3K) signaling cascade RHEB TSC2 BAD RICTOR TSC1 PTEN MDM2 MTOR PMC6723883__F4 model of CFHR1-3 participation in Andes orthohantavirus (ANDV) infection response CFHR3 CFHR1 SIRPB1 PMC4050365__F5 Single-stranded RNA loading to AGO-clade Argonaute proteins DGCR8 AGO2 DROSHA PMC4325211__F3 Placental oxidative stress triggers the expression of transcription factors to regulate angiogenesis and trophoblast invasion STAT3 SP1 KLF8 SP3 PMC8154696__F10 An overview of ODE exposure induced mitochondrial dysfunction in microglia and BSCs TFAM CGAS PINK1 MFN1 MFN2 TLR9 IRF3 TNF PMC6136429__F3 CIN activates cGAS-STING signaling TBK1 CGAS RELA RELB IRF3 TRAF3 TRAF2 CSF1R PMC8564337__F6 Reduced MAGI3 level by HPV18E6 contributes to Wnt/B‐catenin signaling activation and cervical cancer progression MAGI3 CTNNB1 PMC7224363__F1 Chemical reactions triggered by Δ9-fatty acyl-CoA desaturase, EC:1.14.19.1, also known as Stearoyl-CoA-desaturases (SCD), introducing a double bond and thus affecting lipid metabolism FAS FZD4 HMGCR GPX4 APC BAP1 AXIN1 LRP6 CTNNB1 PMC9927011__F1 Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer STAT3 IL13 CXCL5 CXCL1 CXCL2 PMC3581799__F5 Cell-to-cell signaling network generated by ingenuity pathway analysis of differentially expressed genes: Molecules are represented as nodes, and the biological relationship between two nodes is represented as an edge (line) HCAR2 TREM1 FCAR TNFRSF1B BCL2A1 CD36 PTPRC ITGAX CXCL3 CSF3R CCL7 CCR1 FCGR2A IL1B CCL3L3 NOS2 GAL SELL F13A1 CLEC5A FCGR1A SDC1 CLEC4E FCER1G NFKBIA IL8RB S100A9 PMC9927011__F2 Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer CD80 CGAS CTLA4 PMC5465238__F1 Schematic outline of intracellular Ras signaling pathways in the suprachiasmatic nucleus (SCN) regulating circadian clockwork EGR1 PER2 PER1 JUNB CRY2 GSK3B PMC8998406__F1 Notch Signaling Pathway by Bioactive Dietary Agents SOX9 ADAM10 CCND1 NOTCH1 PMC2376243__F8 Schematic mechanism of AB oligomer-mediated aberrant PAK activation and translocation in Alzheimer disease pathogenesis CDK5 FYN TIAM1 PMC7281445__F1 Tumor Necrosis Factor (TNF)/TNF-Receptor 1 (TNFR1)-mediated signalling and cell death checkpoints RIPK3 TRADD MLKL TANK RIPK1 TNF PMC5002480__F1 Cross talk between multiple signaling pathways involved in tumor progression and resistance TF ATR BRCA2 ATM RHO PMC6966522__F2 The IL7R structure and signaling mechanism JAK3 GRB2 JAK1 PMC2949446__F1 Luteolin and gefitinib regulation of EGF Signaling Pathway and Cell Cycle Pathway genes in PC-3 human prostate cancer cells EGF GRB2 PMC8610132__F7 miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer TIMP1 CTNNB1 PMC6491685__F1 Complement system CD59 FH HEL-S-62p C2 VTN CR1 PMC3561537__F6 Scheme of EGFR signaling pathway activated by NEU3-induced GM3 reduction EGF NEU3 EGFR PMC7717145__F1 Disease-based pathway analysis of genes involved in the pathogenesis of lung diseases and respiratory failure MBL2 CSF2 FOXF1 TLR4 NKX2-1 CFTR SFTPC PTEN IL5 TNF ACE2 STRAP PMC3580961__F2 Transcription at damaged DNA XPA PCNA UVSSA XPC PMC8472588__F9 ALK-Negative Anaplastic Large Cell Lymphoma: Current Concepts and Molecular Pathogenesis of a Heterogeneous Group of Large T-Cell Lymphomas STAT3 CD58 ROS1 MSC IL2RA IRF4 JAK1 MYC TYK2 PMC4598026__F5 Tumor Necrosis Factor Alpha and Insulin-Like Growth Factor 1 Induced Modifications of the Gene Expression Kinetics of Differentiating Skeletal Muscle Cells NRK SLC40A1 ASPN CSDC2 UNC13C PARM1 CMBL CAPN6 LIX1 FIBIN SEMA3C AKNAD1 CPA1 SEMA6D SEMA6A SEMA5A SERPINB2 PMC9900921__F7 Simplified de novo sphingolipid biosynthesis pathway UGCG FA2H SI KDSR PMC3906547__F1 Reverse cholesterol transport pathway delivers free cholesterol from macrophages or other cells to the liver or intestine for excretion LDLR PLTP PMC9635594__F3 Schematic diagram showing the role of mucins in cancer metabolism MUC13 HEL-S-133P BRCA1 HEL-S-68p PGM2 HK2 MUC1 PFKFB2 ENO1 TIGAR HEL-S-30 PMC11083431__F6 Possible gene expression changes from enhanced NRF2 signaling and depleted NOTCH signaling in the bile acid synthetic pathway from cholesterol in Keap1F/F::RbpjF/F::AlbCre liver at 3 W of age MAFG CYP8B1 ABCB11 CYP7A1 CYP7B1 NRF1 CYP27A1 PMC7545792__F8 Map of Th17 cell signature cytokines and the IL-17 signaling transduction pathway USP25 IL17RC TBK1 DEFB4B CCL11 TRADD CXCL1 CXCL2 TRAF3 CXCL10 CCL2 CXCL3 IFNG IL17RB CCL7 LCN2 S100A9 CCL20 TRAF2 FADD CCL17 PMC6071257__F1 Epstein–Barr virus (EBV) oncoproteins affecting p53 signaling pathways ING4 MDM2 PMC8065646__F3 Examples of redox regulation of specific transcription factors PDX1 PAX4 KEAP1 PAX6 PMC8065646__F4 Redox targets within insulin secretory pathway and proteins involved in extracellular redox signaling ADAM17 KY SENP1 TRPC1 PRX TRPC5 ACE2 NOX4 PMC9687473__F1 Targeting Adiponectin in Breast Cancer BAX FAS CCND1 PMC12011584__F1 VEGF signaling pathway in stimulating sngiogenesis (By Figdraw2 VEGFB VEGFC PIGF NRP1 NRP2 PMC9635594__F1 Schematic diagram showing the mucins role in cancer stemness and chemoresistance MUC13 STAT3 BAX LMO2 EGFR SOX2 LRP6 CTNNB1 CD44 MUC5AC TSPYL5 FOXO3A MUC1 BCL2 MUC4 CXCR4 GPR49 ABCB1 PMC9635594__F2 Mucin’s role in epithelial to mesenchymal transition (EMT) CDH2 STAT3 MUC5AC MUC4 PMC7597043__F1 Mechanisms of venetoclax resistance CD40 SYK BTK BCR MCL1 BCL2 PMC5425748__F2 Illustration of the multiple signalling pathways for TGFB in the VSMC In the normal state, TGFB is sequestered by microfibrils, bound to fibrillin-1 through LTBP-1 and fibulin-4 interactions, until its required release LTBP1 TGFBR2 TGFBR1 PMC7599957__F1 Network diagram of the model IPP ACAT2 PMVK LDLR MVD FDPS MVK PMC4894418__F5 Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing MAX FAS RAF1 CD14 NLK BDNF DAO FAT2 FLNA TRAF2 PMC7716161__F3 Role of IL-17 in the pathogenesis of acinar duct metaplasia, pancreatic intraepithelial neoplasia, and pancreatic cancer ADM DCLK1 KRAS PMC6497964__F8 The signaling pathway from EPHB6 to catecholamine biosynthesis in AGCCs TF TH EFNB1 EGR1 EPHB6 PMC10820593__F5 Common adjuvants and proposed mechanisms CGAS APP IRF3 IRF7 TNF PMC5391303__F1 Pharmacokinetic and pharmacodynamic evaluation of ibrutinib for the treatment of chronic lymphocytic leukemia: rationale for lower doses SYK BTK BCR PLCG2 LYN CXCR4 PMC8513284__F10 FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway RAB10 ELAVL1 TLR4 CTNNB1 PMC4491123__F1 The miRNA biogenesis and function RAN AGO2 TARBP2 DROSHA PMC8946846__F9 Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway VWF VASP IRAK1 PMC11172514__F1 The mechanism regulating NLRP3 inflammasome activation in canonical, non-canonical, and alternate pathway GSDMD CASP8 NLRP3 IRAK1 TRAF6 IRAK4 FADD MYD88 PMC10513492__F7 Lipid and atherosclerosis and (B) AGE-RAGE signaling pathway in diabetic complications map of Chaihu Anxin Capsule for their potential treatment of depression TH EGR1 SELL NLRP3 TIRAP IRF3 TNF PMC4062707__F2 Signalling pathways activated by chemokine receptors CDC42 JUN PAK1 ROCK1 ARHA MTOR SRC RAC1 PMC1480427__F1 ω3 LC-PUFA and ω6 LC-PUFA biosynthetic pathways FAS GLA TNLG7C PMC7812220__F8 Protein-protein interaction network of hsa-miR-126-5p-related differentially expressed genes KLF2 NCAPG HMMR FUT3 FHL2 TMPRSS4 PGC CA3 SLIT2 MME PPBP MYZAP TLR4 CLEC14A AQP4 ZFP36 SOX17 SCEL CAV2 LRRK2 SELE MMP10 PTGS2 GJB2 FAP EMP1 RGS18 FOXF1 MFAP4 RGS17 CALCRL STX11 PALMD PROK2 P2RY13 CDCA7 EDNRB GKN2 MGAM PTPRB SNTN AKAP12 SCN4B EMCN PMC7812220__F9 Protein-protein interaction network KIF15 KLF2 BUB1B SELE MMP10 NUF2 NCAPG HMMR FUT3 FHL2 TCF21 FAP ATF3 ITGA1 PPBP CDCA7 SULF1 PLOD2 CCNB1 HCTP4 APOLD1 XLKD1 EMCN PMC5610833__F1 Catecholamine synthesis pathway TH PNMT DBH PMC4344511__F4 Estimation of multi-factor mediated dysregulations affected by the module TF EGF EGFR INA ANXA2 ELL KIT PTEN SNX6 CTCF C2 AVIL AHR ADAM12 HEL-S-1 PMC8449320__F7 FGF-2–dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis JUN SPARC FAP PMC4417485__F1 Fission Yeast-based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity GIT2 FBP1 PMC9600294__F5 Adipokines as Regulators of Autophagy in Obesity-Linked Cancer BAX NR1C1 IGF1 ATG12 ULK1 LDLR MTOR ATG5 PMC8350063__F7 LGI1 governs neuritin-mediated resilience to chronic stress HDAC5 LGI1 IRS1 MEF2D PMC8640120__F1 Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers CD40 TH GC PMC11800652__F5 Metabolic maps of Sulfurovum species from Kebrit Deep BSI POR RTCA PMC5471512__F8 Insulin resistance in LMC metabolism, inflammation, and contractility PTEN UNK IRS1 PMC6701246__F1 Mechanisms promoting macrophage phagocytosis of AC by lipid mediators STAT3 GPR32 GPR18 ANXA1 FPR2 RHO IL1B PMC5439269__F3 Eukaryotic DNA mismatch repair (MMR) MSH6 MSH2 PMS2 PCNA POLE PMC5413367__F1 Targeting molecular pathway EGF EGFR SRC PMC6908425__F2 Deletion of fumarases leads to changes in carbon fluxes and amounts of metabolic enzymes RPE RPIA MAL SDHC CIT PMC8072122__F1 Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways APC LRP5 LRP6 PTEN MDM2 MTOR CTNNB1 PMC6908425__F4 Deletion of glycogen synthase in a ΔfumABC strain restores carbon fluxes without changes in amounts of metabolic enzymes SDHD RPE RPIA MAL REL SDHC CIT PMC9315443__F5 Revolution of CAR Engineering For Next-Generation Immunotherapy In Solid Tumors CD40 ICOS CD27 IRF7 MYD88 PMC4668848__F2 Influence of MAP on TLR9 signaling PAK1 TLR9 IRAK1 IRF3 IRAK2 TRAF3 SRC TRAF6 IRAK4 FADD MYD88 PMC4234068__F1 COMPLEMENT REGULATION IN RENAL DISEASE MODELS C6 CD59 FH C7 C2 C9 CR1 PMC7444072__F5 Interaction networks of DMCs according to severe features of PE LRGUK SPP2 STK32A BEND7 DLGAP2 BANP EBF3 MLKL ZIC4 GAS INS-IGF2 ADGRB3 NUMB HLA-DPB1 KRT19 ROBO2 RPL17 KSR2 HLA-F DPYS FAT10 TICAM2 PTPRT DROSHA PTPRN2 BCL11A HEL-S-70p IGF2 VCAN CCDC6 RXRA PCOLCE2 FGFR3 PMC4904104__F5 Disturbed metabolic pathway related to NAFLD and HD-TE treatment LPA TG PSD PTDSS1 PEMT PC PMC6261473__F1 Nrf2–Keap1 signaling pathway KEAP1 MAF PMC12073235__F1 Primary to specialized metabolic flow in Cannabis AANAT PAOX PMC3568263__F2 Defective counterregulation and hypoglycemia unawareness in diabetes: Mechanisms and emerging treatments NTS CRH ARC PMC4905266__F1 Intersection between the Ras and the SUMO pathway in cancer GRB2 SAE1 PMC8577254__F2 Retinoic acid in the commitment to meiosis CYP26B1 CYP26C1 ALDH1A3 HEL-S-53e RDH10 ALDH1A2 CYP26A1 PMC3218933__F3 Embryonic pathway signaling leads to induction of epithelial-to-mesenchymal transition EGF SNAI2 AXL DLL4 KLF8 JAG2 SMO TWIST2 DLL3 TWIST1 SNAI3 CTNNB1 PMC3218933__F2 Cross-talk among embryonic signaling pathways and experimental inhibitors SMAD2 GSK3B SMAD4 IHH PTEN SFRP1 CTNNB1 DKK3 DKK1 FOXC1 JAG2 SMO GRB2 HES1 PMC5390606__F2 A simplified network identified by IPA pathway CDKN1B CCNB1 CCND1 PMC9013942__F2 Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms HSF1 CAP1 TRAF2 SIRT1 PMC9013942__F3 Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms STAT3 BAX ROCK2 JAK1 SRC CXCR4 CCND1 PMC4339951__F1 TGFB pathway in muscular dystrophy TGFBR2 SPP1 PMC3475374__F1 Conceptual schematic of M POR MTR PMC7610648__F3 Replication-coupled ICL repair NEIL3 FAAP24 SLX4 PMC7196371__F12 Functions of exercise in AD HDAC3 BDNF HDAC2 IL1B PMC8485521__F3 MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells GRB2 PMC8883456__F6 Main repair pathways for trapped topoisomerases in humans TDP1 MRE11A SPRTN RNF4 TRIM41 GCNA FAM111A PARP1 PMC8485521__F2 MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells PTEN MTOR PMC9569450__F1 Dual Effect of Tryptamine on Prostate Cancer Cell Growth Regulation: A Pilot Study KYNU KMO HAAO AFMID PMC8385797__F5 Smoking induces sex-specific changes in the small airway proteome FSTL3 FH SPOCK2 HEL-S-62p CD55 PMC7281786__F5 Mitochondrial mediated immune functions and cell signaling IFNG MAVS NLRP3 FPR1 TLR9 IL1B PMC9280276__F2 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer SLC3A2 GPX4 EGFR MT1G SLC7A11 MTOR PMC9280276__F3 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer GPX4 ASCL4 LPCAT3 SLC7A11 PMC9280276__F1 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer STAT3 SLC3A2 TFRC ACSL3 ARF1 GPX4 FACL4 GCA SLC7A11 HEL-75 PMC5364922__F7 Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population PDE3B SHC1 INSR FOXO1 RPS6KB1 PRKAA2 PPARGC1A SOCS3 MAP2K1 PRKAA1 IRS1 PMC9280276__F4 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer SLC3A2 STAT1 CD81 TYRO3 GPX4 PROS1 IRF1 PMC11231459__F2 Tumor progression targeting PDGFR-B signaling pathway, contributed to the pathogenesis of DFSP (created with Biorender.com) STAT1 COL1A1 STAT2 PTEN MTOR PMC9280276__F5 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer SLC3A2 TFRC MTDH SNAI1 GPX4 FACL4 SLC7A11 NF2 TWIST1 PMC11231459__F5 Understanding of FGFs/FGFR signaling pathway in pathogenesis of DFSP (created with Biorender.com) FRS2 FGFR1 GRB2 FGFR2 PMC9519154__F1 Exploring autophagy-related prognostic genes of Alzheimer’s disease based on pathway crosstalk analysis BAGE BAD SELE SCAI ATP6 INS C2 MOS TUB CASP3 PIR MCU APP HEL-S-11 FADD PMC10375783__F2 Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy POR CGAS GPX4 LPCAT3 FACL4 ATM SLC7A11 PMC10375783__F3 Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy IFNG SLC3A2 STAT1 HMGB1 TGFB1 LPCAT3 FACL4 ATM SLC7A11 KRAS PMC11985419__F9 ICAM-1-Mac-1 mediated NET formation mechanism in response to LPS or LTA LTA TLR4 CIT PMC9535304__F4 Molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NFKB pathway under oxidative stress HDAC3 MAFK KEAP1 TRAF6 GPR55 RAC1 PMC2685460__F7 Induction of Distinct TLR2-Mediated Proinflammatory and Proadhesive Signaling Pathways in Response to Porphyromonas gingivalis Fimbriae TIRAP CD14 RAC1 MYD88 PMC4491123__F2 Targets of miRNAs in different cell types of developing mouse lungs SSH2 APC RBL2 ADD3 TIAM1 CDKN1A SRGAP1 SHH KLF5 SMO HEL-S-108 NOTCH3 BDNF NOTCH1 PMC3440872__F4 Model showing a role for Yap in governing cardiac growth and survival by interlinking the Hippo, IGF, and Wnt pathways LATS1 LATS2 APC GSK3B IGF1R CTNNB1 PMC10373097__S1 Rationally designed cancer vaccine based on NIR-II fluorescence image-guided light-triggered remote control of antigen cross-presentation and autophagy PLN MTOR PMC6797510__F10 HOTAIR competitively binds to miR‐206, thereby promoting STC2 expression, activating PI3K/AKT signalling pathway AGO2 STC2 PMC5964020__F2 Cortisol and catecholamine metabolism TH PNMT DBH PMC7936909__F7 Most correlated MAPK signaling pathway enriched in KEGG mapper FLNA STS PMC2756058__F1 Pathway of cellular processing of cobalamin (OH-cbl) and location of main enzyme defects in the pathway leading to methylmalonic acidemias and cobalamin metabolic disorders MMAA MMACHC CBL MMADHC MCEE PMC6274736__F1 Schematic diagram of c-mesenchymal–epithelial transition (c-MET) activation signaling pathways STAT3 HGF ALK EGFR GRB2 PMC6274736__F2 Targeting HGF/c-MET pathway in digestive system cancers by microRNAs STAT3 HGF MMP2 MTOR VEGFA PMC3435197__F2 Spectrum of somatic mitochondrial mutations in five cancers CYB HEL-S-26 PMC8584253__F7 PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway SOX2 MTOR MYC CD47 PMC3549672__F2 Ubiquitination in Signaling to and Activation of IKK TRIM25 MIB1 MIB2 IRF3 PMC8519338__F1 Macrophage Activation Syndrome and COVID 19: Impact of MAPK Driven Immune-Epigenetic Programming by SARS-Cov-2 TLR3 TLR4 CD14 ACE2 IL1B MYD88 PMC4104414__F1 Figure shows the endothelial response to a high salt diet TGFB1 SMAD2 PTEN PMC3549672__F3 Ubiquitination in Signaling to and Activation of IKK BCL10 TRAF6 PMC4453619__F7 Molecular genetic model (adapted from ; ; ; ) FZD5 LRP5 TCF2 LRP6 CTNNB1 PMC7738893__F1 Action of monoclonal antibodies (mAb) in cancer therapy CDC42 ZAP70 STAT3 BAX SYK APC CTLA4 MTOR VEGFA SRC FADD PMC7738893__F3 Molecular mechanisms for impaired antibody therapeutic activity in cancer C6 IL10 CD7 PMC6302140__F11 Schematic depicting the proposed molecular mechanism by which citrate regulates cellular redox signaling pathways in BMSCs COX7B GOLT1B RAB27A DCXR ATP6V1D EDF1 SGSH MYL12B PMC9634730__F1 Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment FOXP3 MYC PMC9535304__F2 Molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NFKB pathway under oxidative stress RBX1 BACH1 KEAP1 MAF PMC8605525__F8 Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3 STAT4 RUNX3 PMC4012776__F1 Trim21 negatively regulates the DDX41-mediated signaling pathway TBK1 DDX41 IRF3 IRF7 TRIM21 PMC9099524__F5 Hypoxia as a Modulator of Inflammation and Immune Response in Cancer STAT3 EGF MAP3K7IP1 COX2 SRC TRAF6 IL1B VHL PMC3591623__F7 Model for the putative mechanism by which Fsk-cAMPi negatively regulates IL-2R signaling in human T-cells JAK3 IL2 JAK1 PMC7189297__F1 Relationship between EPO and FGF23 metabolism SCD EPO FGF23 PMC6984609__F1 Role of autophagy in the maintenance of intestinal homeostasis and potential mechanisms by which defective autophagy may contribute to CD development TIRAP MCL1 GSK3B MTOR ERN1 EIF2AK4 CASP14 RIPK2 NLRP3 IL16 TLR4 NOD2 IL18 CHUK FOXP3 OPTN IL1B IL10 IF2B1 LRRK2 IRGM LRP3 IRF3 IL6 TNF CLDN2 PTPN22 CASP3 BCL2 IFNB1 RAB2A PMC9099524__F1 Hypoxia as a Modulator of Inflammation and Immune Response in Cancer EPO MMP2 VHL PMC9099524__F2 Hypoxia as a Modulator of Inflammation and Immune Response in Cancer STAT3 COX2 KRAS IL1B PMC6109480__F1 PD-1/PD-L1 signaling and reprograming in T cells LAT APC GIP PTEN MTOR LCK PMC6689979__F2 Subcellular compartmentalization of sphingolipid metabolism KDSR SKI SPP1 PMC8641543__F5 Inhibitors of nucleotide synthesis SLC25A38 MTHFD2 MTHFD1 PHGDH MTHFD1L SHMT1 SFXN1 TYMS SLC6A9 HEL-S-51e DHODH PMC3307959__F5 Unconventional roles of kinesins in cell signaling KIF26A GDNF APP SMO GRB2 CIT PMC6383653__F6 Signaling pathway activated by OxPAPC XPA FYN PAK1 SRC RAC1 PMC4604749__F4 Life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics RHEB HEL-S-92n TSC2 DDA1 TSC1 HNRNPK NCL PMC6383653__F4 Proposed model for the cross-talk between HGF/c-Met and SphK1/S1P/Spns2/S1P1 signaling axis in HGF-mediated lamellipodia formation SPNS2 HGF RAC1 PMC3128772__F6 Cell signaling between rNSCs and hMSCs in coculture GFAP TGFB1 NOTCH3 PMC4633353__F7 Constitutive control of AKT-1 gene expression by JUNB / CJUN in ALK+ anaplastic large cell lymphoma: a novel crosstalk mechanism STAT3 JUN JUNB JAK3 MTOR SRC PMC7726326__F7 Gene interaction network of upregulated and downregulated DEGs in TP-treated PC1 (A,B, respectively) and PC2 cells (C,D, respectively) identified by STRING software using a high confidence interaction score (0.700) SRGN ACLY FUS HELLS FOSB EBP DTL SQLE DHCR24 CLSPN GNAL FGF2 PLAT NOP2 CENPH CENPK CENPP MMP3 FDPS MCM2 PMC3599046__F2 Toll-like receptor signaling pathway in response to MDV infection TLE2 TIRAP ELL CTSK CD14 TRAF6 LBP FADD PMC7761032__F2 Potentials and Pitfalls of a Human Cervical Organoid Model Including Langerhans Cells STAT3 JAK3 STAT4 JAK1 TRAF2 TYK2 PMC3599046__F1 JAK/STAT signaling pathway in response to MDV infection EPO PIN1 PMC9030480__F2 Translational Strategies to Target Metastatic Bone Disease TARP PTH CCL2 PMC3917750__F1 Dual regulatory effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) on neuronal apoptosis PCSK9 BAX BACE1 PMC5256122__F1 Representation showing the mutations associated with the RAS/RAF/MEK/ERK pathway observed in melanoma CDK6 GNA11 BRAF NRAS PTEN MDM2 MTOR CDK4 PMC6400990__F2 Schematic overview of glycine metabolism and six genetic loci for glycine in/near genes encoding enzymes related to glycine metabolism GLDC GCSH PHGDH PSPH PMC8745614__F5 Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells TIMP1 ATP1A1 SNRPC COL3A1 GNAS GSTM4 GSTM1 ADAM15 RBPMS HP1BP3 RRM2B HEL-S-108 SPG20 ZC3H11A TCEA2 CP PMC8601173__F1 Metabolic engineering of microorganisms for the production of multifunctional non‐protein amino acids: G‐aminobutyric acid and D‐aminolevulinic acid MAL PTS CPO CIT PMC9204890__F5 Genome-wide alternative splicing profile in the posterior kidney of brown trout (Salmo trutta) during proliferative kidney disease BAT2L ACTN1 UBN2 PLEKHM2 SHD OPA1 SNX5 MYD88 TPM1 RFFL PHKB HAAO MB AHCYL1 PTPRH PMC9643771__F1 Updates in combined approaches of radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer TBK1 CGAS IRF3 PMC2930805__F1 Metabolic signaling pathway of candidate pathway TSC2 TSC1 PTEN MTOR IRS1 PMC11519876__F1 Reelin signaling pathway in Alzheimer’s disease (AD) DAB1 VLDLR SRC PMC7986695__F2 Crucial cells and molecules involved in postsynaptic responses in the regenerative niche at the vertebrate neuromuscular junction (NMJ) MUSK LRP4 MMP3 PMC6447849__F1 Biogenesis of miRNA DGCR8 AGO2 POLI DROSHA PMC5468653__F3 Prolific nicotine production in the genus Nicotiana evolved from stepwise duplications of two primary metabolic pathways DAO MPO PMC3729926__F6 Aldose Reductase Inhibition Enhances TRAIL-Induced Human Colon Cancer Cell Apoptosis through AKT/FOXO3a-dependent upregulation of Death Receptors BAX BCL2 FADD PMC7280878__F4 Target genes and pathways of COL-3 and CGP-60474 in treating lung injury in COVID-19 CDC42 MMP14 FAS VASP PXN CCL2 FLNA HEL-S-99n BCL2L1 MAP2K6 WAS MMP3 HEL2 HEL-S-15 CDK4 JUN PFN1 ARHA TNF FOS CHD4 EIF4G1 GSK3A ARHGEF7 SNX2 HLA-B HLA-C GNG11 HLA-A YWHAZ PMC9400233__F5 Two-stage genome-wide association study to identify novel genetic loci associated with acute radiotherapy toxicity in nasopharyngeal carcinoma KLF4 STAT3 TFCP2L1 INHBB RHOF SMAD2 SMAD4 PTPN4 SIRT1 PMC5241319__F2 Autocrine and intracellular complement activation NLRP3 HEL-S-62p CTSL CD46 MTOR IL1B PMC4896923__F1 Involvement of Notch in the regulation of myelination and axonal growth EGF MAFK NGF F3 NUMB ADAM10 NOTCH2 RBPJ NOTCH1 PMC4896923__F2 NRG/Erb signaling in the control of peripheral myelination and axonal growth ERBIN RAPGEF2 GDNF ERBB4 ERBB2 LINGO1 GRB2 MTOR BDNF RET PMC5241319__F3 Systemic complement in metabolism TG C5AR2 HEL-S-62p C1S C4B_2 PMC7917964__F10 Ingenuity Pathway Analysis NR1i1 STAT3 PPARG JUN IL33 CEBPA TSLP RORC NR2A1 TLR4 NFE2L2 AHR CEBPB PMC7606547__F4 Construction of a complete set of Neisseria meningitidis mutants and its use for the phenotypic profiling of this human pathogen ECD tmp_locus_29 INA PIR FES ADA PMC2366099__F1 Folate and one-carbon metabolic pathway TCN2 PON1 MTRR HEL-S-61p MTR PMC4664912__F6 Transcriptomes reveal the genetic mechanisms underlying ionic regulatory adaptations to salt in the crab-eating frog ALB NR3C2 EHHADH SCNN1G AVPR2 ATP6V1G3 ATP6V1F CTSA AVP PMC4876452__F5 Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis SYK TLR1 TLR4 NOD2 RNASEL IRF3 NOD1 OAS1 TRAF6 TNF OAS2 MYD88 PMC4876452__F6 Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis CD40 LTA NLRP14 NLRP10 IRAK1 NLRP9 NLRP2 MPO NLRC4 NLRP12 NLRP6 NLRP3 TLR4 NOD2 NOD1 GRB2 TLR10 IL1B PMC4876452__F7 Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis HTRA2 PARP10 FAS CASP8 TRADD LIMK1 CYCS TANK ACIN1 GAS2 DFFB ZC3HAV1 ARHGDIB CASP6 ROCK1 DFFA CASP3 APAF1 TRAF2 CASP10 DIABLO LMNA FADD SPTAN1 PMC12058784__F3 Related biological functions in bone tissue FUS HMGB1 HEL-S-7 PMC9251379__F4 Molecular Mechanism of Yellow Mushroom (Floccularia luteovirens) Response to Strong Ultraviolet Radiation on the Qinghai-Tibet Plateau TH MAL FECH PMC10453365__F1 Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling JUN COX2 TLR4 IRAK1 IRF3 IRF7 TRAF6 FOS IRAK4 MYD88 PMC7662962__F2 Platelet activation by CXCR chemokine receptors CXCL11 CXCR6 CXCL16 MIF CXCR4 PMC1867370__F9 Root Phenotypes of Wild-Type, noxy2, and coi1-1 Plants Responding to Oxylipins.Ten-day-old seedlings grown on MS medium and in the presence of 9-HOT (25 μM), 9-oxo-C9 (15 μM), or JA (10 μM) LOX tmp_locus_29 PMC3531730__F6 Proposed model for the signaling pathway mediating NFKB activation induced by C-type lectin receptors SYK BCL10 PLCG2 TRAF6 CARD9 PMC3183592__F1 Normal hepatic methionine metabolism PEMT PC PMC5347794__F9 Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway BAX GEM EIF2A PMC9355550__F2 Combinatorial Strategies With PD-1/PD-L1 Immune Checkpoint Blockade for Breast Cancer Therapy: Mechanisms and Clinical Outcomes APC PMC5272919__F2 Opportunistic intruders: how viruses orchestrate ER functions to infect cells DNAJB12 DNAJB14 DNAJC18 SGTA PMC10384840__F9 Natural Flavonoids Quercetin and Kaempferol Targeting G2/M Cell Cycle-Related Genes and Synergize with Smac Mimetic LCL-161 to Induce Necroptosis in Cholangiocarcinoma Cells RIPK3 TRADD C2 MLKL RIPK1 GLA TRAF2 PMC4112617__F1 Insulin-like growth factor pathway IGF2R IGF1 IGF1R IGF2 PMC9266441__F2 Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NFKB Signaling Pathway CGA COX1 TIRAP TLR4 IRAK1 IRF3 TRAF6 IRAK4 MYD88 PMC6399612__F9 Myogenin promoter‐associated lncRNA Myoparr is essential for myogenic differentiation POLI PMC9657829__F6 DNA Methylation in Neurological Diseases TET2 ADK MBD5 RELN PMC6164146__F2 Activation and Attenuation of IL-33/ST2 Signaling IL33 SIGIRR IRAK1 TRAF6 IRAK4 MYD88 PMC9657829__F4 DNA Methylation in Neurological Diseases BRCA1 BACE1 APP PSEN1 PMC7778457__F2 FA signaling in the DNA ICL repair pathway BRIP1 ATR RAD51 BRCA2 FANCM PIN1 UBE2T FANCD2 RAD51C REV1 BRCA1 FAAP24 RFWD3 UHRF1 PALB2 SLX4 PMC6100577__F3 Double strand break chromatin stability mechanisms CDC2 BARD1 LIG1 RNF168 RNF8 ATM PARP2 MDM2 MDC1 BLM PARP1 PMC8528729__AF1 MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer NEUROD1 ASCL1 POU2F3 YAP1 PMC10960969__F8 Metabolic pathway of methanotrophs EMP1 IDE HEL-S-304 OGDH HEL-S-162eP CYC1 CS HEL-S-26 TNLG7C PMC3037747__F4 BCR, NFKB, and PI3K/AKT/mTOR deregulation in MCL TSC2 BCR RELA RELB FAF1 BLNK PTEN PMC12052849__F5 Proposed working model of apoptosis regulated by USP18 through the PERK-eIF2Alpha-ATF4 signaling pathway BAX USP18 ATF4 PMC7804490__F2 T cell signaling by E3 ligases and DUBs CDC42 ZAP70 TSC1 USP15 FOXO1 LAT MDM2 CYLD FBXO38 PELI1 PMC10545718__F1 Bioactive lipid-mediated regulation of insulin downstream signaling and lipid metabolism in adipocytes: mechanistic overview TG PDE3B NR1C1 CRAT CD36 IRS1 PMC4607871__F2 Spindle assembly checkpoint and error correction CDC2 MCC CDC20 APC PMC10545718__F2 Genetic deletion of lipid biosynthetic and metabolic enzymes on adipocyte metabolism TG PDE3B ORMDL3 CD36 TMEM86A PMC9396482__F1 Wnt/Beta-catenin signaling: a multifunctional target for neuroprotective and regenerative strategies in Parkinson’s disease DKK1 APC WNT1 CNP PMC5765398__F2 Mucosal tolerance in the gut and its breakdown in food allergy FCER1A CX3CR1 NRP1 IRF4 IRF8 CR1 GATA3 PMC5969551__F2 Role of Cic in Ras-MAPK signaling and growth control LATS2 CIC TEAD2 TEAD3 TEAD4 PMC5902686__F7 Putative metabolic pathway of drought stress responses in flag leaves and developing grains of Zhongmai 175 IPP CFI HEL-S-162eP GIP PMC3037747__F2 Cyclin D1, at the center of MCL pathogenesis CDK6 GSK3B CDK2 ATM CDT1 MTOR CCND1 CDK4 PMC7290580__F3 Signaling pathways by cIAP-mediated degradation of TRAF2 and/or TRAF3 TRAF1 TRAF3 REL TRAF2 MYD88 PMC6424867__F6 Arenaviral proteins (NP and Z) inhibit the RIG-I/MDA5 and NFKB pathways MAVS MAL IRAK1 IRF3 IRF7 MYD88 PMC6392423__F8 Protein kinase C pathway for prolactin regulation of metabolic gene expression in prostate epithelial cells as represented by mitochondrial aspartate aminotransferase TF JUN PRL FOS PMC6287621__F1 Specific targets and potential therapeutic strategies to inhibit or slow the progression of CKD HGF TGFBR3 BMP7 NOX4 PMC12041846__F6D DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity GRIP2 AKAP5 GRIP1 TARP MYO6 PICK1 PMC8257731__F1 Detailed drawing of the fine molecular mechanisms of lithium on specific cell targets IFNG STAT3 GSK3B MTOR BDNF TNF XBP1 PMC11076692__F2 46,XX Testicular and ovotesticular DSD NR5A1 SOX10 CTNNB1 RSPO1 FGFR2 DMRT1 WT1 FOXL2 NR2F2 SOX9 SRY FGF9 SOX3 WNT4 SOX8 PMC11076692__F1 Genes and mechanisms of sex determination CBX2 NR5A1 SOX10 CTNNB1 FGFR2 DMRT1 LHX9 WT1 EMX2 FOXL2 NR2F2 SOX9 SRY FGF9 GATA4 PMC2417187__F7 Activation of the UPR in the absence of H6PD HEL-S-99n ATF4 XBP1 PMC7695361__F7 Mechanism diagram of the KEGG pathway LRP5 SMAD4 LRP6 BAMBI HDAC1 RBL1 NGF CDK6 CCND2 COX2 E2F4 RELA GADD45B TRAF1 VCAM1 SAMD3 CDK4 IL1B PMC6539093__F2 Schematic view of the ERK pathway in response to growth factors, hormones, and mechanical stress ERBIN ANKRD1 SHOC2 FHL1 PMC7460641__F3A Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop GAL BAD STH SI AGA PMC4272446__F2 NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease JUN TNFAIP3 ITCH OTULIN TAB3 MAPK8 CXCL8 IKBKG MAPK14 DEFB1 RIPK2 RELA NOD2 NFKBIA BIRC2 BIRC3 PMC4005353__F1 AGS genes cooperate to metabolize reverse transcription products of endogenous retroelements TBK1 IRF3 TREX1 PMC3426484__F1 Asparagine N-Glycosylation pathway GMPPB MAN1A2 ALG11 MAN1A1 ALG9 GANAB MAN2A2 DPM3 MAN2A1 MGAT1 DOLPP1 MGAT2 MGAT4B OS9 DPM2 RFT1 ST8SIA6 ALG2 ALG3 ST8SIA2 DPAGT1 PMM1 SIAT4C ALG12 MANEA EDEM3 DOLK ALG6 PGM3 ALG10 MGAT3 ALG13 ALG1 PMC8687818__F5 Anticancer Action of Xiaoxianxiong Tang in Non-Small Cell Lung Cancer by Pharmacological Analysis and Experimental Validation BAX NOS2 EGF JUN SELE EGFR GLA MYC CCL2 FOS INSR RELA RXRA CASP3 CDK2 BCL2 PMC8973075__F3 Mesenchymal Stromal Cells for Enhancing Hematopoietic Engraftment and Treatment of Graft-Versus-Host Disease, Hemorrhages and Acute Respiratory Distress Syndrome TF CD59 FH HEL-S-62p TFPI MSC CD46 CD55 PMC12128733__F8 Hypothetic molecular mechanisms and modes of the pharmacological action of adaptogen are updated from the authors’ free access publication [66] and authors’ drawings COX2 CRH IL6 TNF PMC8687818__F8 Anticancer Action of Xiaoxianxiong Tang in Non-Small Cell Lung Cancer by Pharmacological Analysis and Experimental Validation CASP9 EGF JUN CHRM2 RELA CASP3 CDK2 CCNA2 MYC PMC7383626__F1 Non–small cell lung cancer tumorigenesis pathways and mutation frequencies are illustrated PIK3CA ROS1 ALK NF1 EGFR NTRK1 BRAF FGFR3 PTEN KRAS RET PMC12128733__F9 Effect of Rhodiola extracts on the eicosanoid signaling pathway LTBR ALOX15 ALOX12 PTGIR PMC5320608__F10 Schematic model of TREM2 in the regulation of Beta-catenin signaling and microglial survival TREM2 SYK WNT3A CCND1 CTNNB1 PMC8268497__F6 Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development MIB1 ADAM10 RBPJ PMC11502356__F6 Insulin signaling pathway and the shortlisted key mRNA markers STAT3 PRDM1 GSK3B PTEN MTOR IRF4 MYC FOXO1 TLR4 BCL2 ATM MDM2 SRC PMC4599573__F13 Schematic diagram shows that PLB regulates the Nrf2-mediated oxidative signaling pathway and its downstream proteins NQO1, GST, and HSP90 in SCC25 cells.Abbreviations: ROS, reactive oxygen species; GST, glutathione S-transferase KEAP1 NQO1 MAF PMC3989738__F6 Direct target genes of hypoxia-mediated hypoxia-inducible factor-1A (HIF-1A) signaling HMOX1 HEL-S-133P HEL-S-68p EDN1 SLC2A3 HIF1A VEGFA PMC7936035__F7 Not Frozen in the Ice: Large and Dynamic Rearrangements in the Mitochondrial Genomes of the Antarctic Fish ATP8 COX1 COX2 COX3 ATP6 PMC4636767__F5 Schematic presentation of a model highlighting the probable mode of action of AMA on placental development CCL3 IL16 IL2RA IL6 CCL5 MIF CXCL10 CCL2 TNF PMC9540681__F2 Human–rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic–ischemic pathway melatonin‐sensitive BAX EGF NGF CDK6 IGF1 PTEN GRB2 MTOR SHE CDK4 PMC3156782__F2 Wnt/Beta-catenin signaling pathway generated by Ingenuity Pathway Analysis (IPA) CD44 TCF4 MDM2 NLK MYC AXIN2 WIF1 PMC8243607__F6 Transcriptomics identifies key defense mechanisms in rice resistant to both leaf-feeding and phloem feeding herbivores MYB ERF PMC6043822__F6 The main modulated genes and their reciprocal interactions in the cell KRT18 PTGER2 THBS1 ALPL TGFB1 FLNB HMMR GAS PCOLCE G0S2 CCNA2 PHLDA1 CNN3 BMP2 PCOLCE2 WNT4 VCAM1 RCAN1 PMC6559886__F5 Fistein Suppresses Human Osteosarcoma U-2 OS Cell Migration and Invasion via Affecting FAK, uPA and NF-ĸB Signaling Pathway In Vitro EGFR ARHA GRB2 CTNNB1 PMC8139523__F2 Take a Walk to the Wild Side of Caenorhabditis elegans-Pathogen Interactions TF SGK1 PMC7268632__F2 Endoplasmic Reticulum (ER) Proteostasis Network RTCB ATF4 EIF2A XBP1 TRAF2 PMC12004596__F1 Inhibition of T‐cell activation ZAP70 CD80 HMGB1 FGL1 APC PTEN LCK PMC7268632__F3 Novel Outputs of the Unfolded Protein Response (UPR) Related to Learning and Memory Processes ATF4 EIF2A BDNF XBP1 PMC8509383__F2 Melatonin as a Therapeutic Agent for the Inhibition of Hypoxia-Induced Tumor Progression: A Description of Possible Mechanisms Involved SEMA4D LOX ANGPT1 BCL2 CTSC PMC8901478__F2 Talimogene Laherparepvec: Moving From First-In-Class to Best-In-Class POR CGAS IRF3 JAK1 TNF TYK2 PMC5455318__F2 Hyperinsulinemia on the tumor cell microenvironment and intracellular signaling that contribute to tumor growth and progression IGF1 IGF1R IGF2 IRS1 PMC6122270__F4 Multiple pathways of CD44/CD44v6-promoted CIC motility: CD44/CD44v6 drive CIC motility by activation of signaling cascades as well as protease activation STAT3 ADAM17 GEM EGFR LRP6 ADAM10 ARHA CXCR4 CTNNB1 PMC4633447__F4 Schematic diagram showing the possible consequences of SLC7A3 dysfunction on the mTOR and NO pathways RHEB MLST8 TSC2 TSC1 ULK1 PTEN MTOR DEPTOR EIF4E PMC5110160__F10 Acute Simian Varicella Virus Infection Causes Robust and Sustained Changes in Gene Expression in the Sensory Ganglia TBX2 RASSF2 ROGDI NR1H2 MAFG USF2 SOX10 FLNA RAC3 EEF2K ADRM1 PRKCSH MBP PDPK1 HSF1 FGFR1 HDAC11 HEPACAM GNB2 SOX2 SREBF2 LDB1 SHE HEL-S-47e GFAP PADI2 FKBP2 EPN1 AATK PPP1R9B CHMP1A ENPP2 APLP1 PMC8506063__F7 Bioinformatics analysis reveals the roles of cytoskeleton protein transgelin in occurrence and development of proteinuria LPL SYK BAD UBC UCP1 HEL-S-28 RBL2 PTEN CD19 ME1 MYC RAC1 IRS1 EIF4E TSC2 OLR1 TSC1 AQP7 BRCA1 BCR PLTP CDC37 MDM2 GRB2 PMC6122270__F3 CD44/CD44v6 and CIC apoptosis resistance MMP7 HBEGF FAS HGF ERBB4 LAT CASP3 PC CDC37 GRB2 MMP9 PMC6085123__F5 NOD-like receptor signaling pathway STAT1 CASP8 TXNIP IL16 TLR4 IL18 AIM2 JAK1 TYK2 IRAK4 CARD9 PMC2818233__F2 Nuclear phosphoinositide-mediated stress response pathway RBX1 PDX1 SPOP PMC7494507__F2 Regulatory mechanisms of CD47 expression.Regulators of CD47 expression in cancer cells includes cytokines, oncogenes, microRNAs as well as enzymes STAT3 IL16 SIRPA QPCTL MYC CD47 PMC7283076__F1 Cytokine storm induced by SARS-CoV-2 STAT3 STAT1 CXCR1 STAT2 IRF9 IL18 JAK1 TYK2 MYD88 PMC2323406__F4 Stimulus Design for Model Selection and Validation in Cell Signaling EGF EGFR GRB2 PMC7283076__F2 TLR recognizes extracellular PAMPs and initiates the transcription of NLRP3, proIL-1B, and proIL-18 through the NFKB signaling pathway, and oligomerized NLRP3, ASC and pro-caspase-1 form a multiprotein complex that activates caspase-1 HMGB1 NLRP3 IL1B PMC4155598__F8 CDK 4/6 inhibitors sensitize PIK3CA Mutant Breast Cancer to PI3K inhibitors CDK6 MTOR CCND1 CDK4 PMC8113420__F1 Possible mechanistic links between the activation of the PKR-eIF2A branch of the ISR and hippocampal/cortical plasticity under physiological and age-related neurodegenerative conditions ATF4 EIF2A RAX PMC5485424__F9 Schematic model of BRAFV600E signaling-induced epigenetic silencing by H3K27me3 in tumorigenesis MAX EZH1 SUZ12 EED AEBP2 GC EZH2 DROSHA JARID2 SET PMC8459449__F1 Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress REST SENP1 HEL-S-26 FFAR1 PMC8634673__F1 Epstein-Barr Virus and the Origin of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome IFNG TH HEL-S-92n FOXP3 CCL20 HLA-DQB1 PMC8429127__F1 Sulforaphane-Nrf2-GSTM1 pathway in the prevention of kidney disease progression: Gene - diet interaction GSTM1 KEAP1 NQO1 AKR1C1 PMC6717205__F1 Schematic overview of glycolysis and mitochondrial respiration HEL-S-133P F2 LDHB PMC3748992__F5 Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma CALML3 GNG12 DCT TYRP1 HEL70 RAC3 PMC9131252__F1 Electrical charge on ferroelectric nanocomposite membranes enhances SHED neural differentiation ERBB4 ERBB2 ARHA MTOR PMC3835203__F1 New mechanisms of NOD-like receptor-associated inflammasome activation GBP5 MAVS NLRP3 TLR4 TNF BRCC3 PMC5732032__F1 Targeting EGFR Co-dependent Signaling Pathways in Glioblastoma EGFR PTEN MTOR SRC PMC5286880__F5 Interferon signaling pathway as differentially regulated by ZIKV and HCMV in maternal-decidual and fetus-derived chorionic villus tissues IFNG BAX IFITM2 IFITM1 IFIT3 IFI35 TYK2 PMC2981097__F2 Double strand DNA repair: Homologous recombination and Non-homologous end joining BRIP1 RAD52 RAD21 RAD50 RAD51 BRCA1 H2AX BRCA2 ATM ZNF350 PALB2 XRCC3 PMC5732032__F4 Targeting EGFR Co-dependent Signaling Pathways in Glioblastoma BRD4 SOX9 LDLR ABCA1 FOXG1 PMC8088128__F3 Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective RPTOR ERBIN PIK3CA FBXW7 SHOC2 SCRIB VCP HUWE1 PMC8980014__F1 CSNK2 phosphotargets, associated pathways, and CSNK2-regulated phenotypes identified in this review STAT3 TSC2 TSC1 EGFR IKBKB RELA NFKBIA CHUK PTEN MDM2 MTOR IKBKG PMC9457836__F5 Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia IL13 IL33 IRAK1 IL6 IL5 MYD88 PMC8424196__F4 Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease RAB4A DTX1 DTX3 DTX4 DTX3L IRF1 ADAM10 METTL3 CXCL10 PARP1 PMC10417792__F1 The MET signaling pathway and the sites of action for MET targeted therapies STAT3 HGF EGFR GRB2 MTOR SRC RAC1 PMC2749725__F1 Coverage of the insulin receptor signaling pathway CRK BAD CRAT GRB10 RS1 OCEL1 PTEN GRB2 MTOR EIF4E PMC3253327__F1 Acute and Chronic Regulation of Aldosterone Production HSD3B2 STAR CYP11B2 CYP11A1 PMC3253327__F2 Acute and Chronic Regulation of Aldosterone Production STAR PC MC2R PMC8424196__F3 Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease TBK1 DTX1 DTX2 DTX4 DTX3L FABP4 IRF3 FOXP3 PARP1 PMC8088128__F5 Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective RAF1 SHOC2 BRAF PMC7361619__F1 COVID‐19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches LPL LTB ABCG1 PON1 APOE LDLR MIP ABCA1 ACE2 PMC8124226__F7 Microencapsulated Bifidobacterium bifidum and Lactobacillus gasseri in Combination with Quercetin Inhibit Colorectal Cancer Development in ApcMin/+ Mice FRAT1 APC GSK3B PPP2CA FBXW4 LEF1 CTNNB1 PMC8948217__F3 Notch signaling pathway: architecture, disease, and therapeutics SOX9 TCF2 HNF1A PMC8948217__F5 Notch signaling pathway: architecture, disease, and therapeutics CXCL5 FOXP3 CCL2 GATA3 PMC4988489__F2 The piRNA Pathway: Guardian of the Genome –A Fly’s Perspective ME1 AGA PMC8802807__F12 Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary EGF HBEGF TGFA EGFR BTC PMC7350315__F3 Schematic overview of the classical ATM and ATR DDR FANCD2 ATR ATRIP H2AX RAD17 ATM PMC7350315__F4 ATR signaling pathway is involved in the HPV life cycle FANCD2 TOPBP1 ATR RRM2 GATA4 PMC3696796__F5 Schematic depiction of LB-205 effects on NGF stimulated pathways BAX NGF APAF1 PMC7822850__F8 LINC01152 upregulates MAML2 expression to modulate the progression of glioblastoma multiforme via Notch signaling pathway MAML2 RBPJ PMC9358040__F4 Dysregulation of Subcutaneous White Adipose Tissue Inflammatory Environment Modelling in Non-Insulin Resistant Obesity and Responses to Omega-3 Fatty Acids – A Double Blind, Randomised Clinical Trial TCF20 MMP7 FZD5 DACT2 TCF12 TGFB1 APC LRP6 APC2 CTNNB1 CD44 RARA TCF3 TCF7L2 SFRP4 WNT3 FZD1 CSNK1A1 SRC CCND1 TCF23 PMC6275040__F1 Schematic representation summarizing the transforming growth factors-beta (TGFB) receptor complexes and signaling pathway in endothelial cells SMOC1 HMFT1766 SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC5299619__F1 The canonical T2R signaling pathway TRPM5 PLCB2 CALHM1 PMC8969576__F3 Targeting Chitinase 1 and Chitinase 3-Like 1 as Novel Therapeutic Strategy of Pulmonary Fibrosis CHI3L1 CD44 IL10 CHIT1 CCL2 PMC7352656__F1 Molecular mechanisms for acquired resistance STAT3 EGF HGF AXL EGFR PTEN IGF1R MTOR PMC6148305__F12 Hypothetical pathway of MIF-2/D-DT-dependent mechanisms in proximal tubule cell regeneration CD44 CD74 SLPI ATF4 EIF2A CCND1 PMC7880315__F8 Working model of Beta-elemene and RT on tumor growth in NSCLC cells CDH2 CD44 PMC3468386__F1 The canonical Wnt signaling pathway APC CTBP1 INS PMC2675709__F5 Comparison of metabolites and transcripts in glycolysis, tricarboxylic acid (TCA) cycle, and pH-regulating pathways between the wild type (WT) and the stop1 mutant ME2 GAD1 ME1 PMC7071121__F6 Proposed mechanism for RPG in regulating the uterine involution in post-natal dairy cows IGF2R IGF1 IGF1R MTOR IGF2 PMC7261103__F2 Role of renin/angiotensin system (RAS) and kallikrein/kinin system (KKS) in pathogenesis of COVID-19 TMPRSS2 PLG ACE2 PMC8277969__F3 Metabolic reprogramming in cancer: mechanistic insights from Drosophila OGT EGFR CSK SCRIB MYC PMC4369962__F4 Calcium signaling pathway in old nitrate treated aorta PLN CAV3 CAV2 TNC BCR MCU PMC7412701__F6 Schematic diagram and potential mechanisms of sotrastaurin inhibition effect on osteoclast resorption DCSTAMP CTSK ACP5 PMC11262449__F1 Genes involved in glucose sensing, the reward system, sweet taste receptors, the endocannabinoid system, and insulin mediated glucose uptake found to have SNP associations with dietary sugar intake and/or cardiometabolic risk factors in children INSR IRS1 PMC8229527__F1 NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications PLCG2 DAP VAV1 PMC9352970__F2 Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role? NLRP3 VCAM1 MTOR TNF PMC7141637__F1 Proposed model for SARS-CoV-2-associated diarrhea TMPRSS2 MTOR ACE2 PMC7767049__F2 Administration of Beta-AR blockade can enhance the efficacy of RT by modulation of tumor microenvironment in irradiated and non-irradiated tumors CXCL9 IFNG CXCR3 LYPD3 HK2 CXCL10 PMC4865030__F1 Interplay between Fanconi anemia and homologous recombination pathways in genome integrity BRIP1 TOPBP1 ATR RAD51 WRN BRCA2 FAN1 BLM UBE2T RAD51C DNA2 BRCA1 FAAP24 GEN1 PALB2 SLX4 PMC6478283__F13 Identification of key regulatory genes connected to NFKB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network EGF RAN JUND BAD OTOR EGFR NFKB2 RELB EPO ATF2 TRAF6 FGFR2 LPA STAT1 EPOR TLR4 UNG IL2 ATM HEL-S-11 TPO JUN JUNB ARHA TNF FOS NFKB1 BCL2 STAT4 VCAM1 REL PMC4683444__F5 Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity STAT3 RAF1 TRADD LEPR DCT KIT SOCS3 TNF KITLG IRS1 HRAS NR1C1 NFKB1 POMC CHUK NPY MAP2K1 TRAF2 PMC12193766__F3 Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology KEAP1 GCLC MAF PMC5622249__F6 Schematic diagram of hypothetical mechanisms underlying chloroquine enhances sensitivity to cisplatin in ovarian cancer cells MTOR ATG5 PMC5857537__F2 Molecular alterations in aldosterone-producing benign adrenal cortical neoplasms KCNJ5 CYP11B2 ATP2B3 PMC5386520__F2 Gas6 and TAM receptor signalling STAT3 BAD TYRO3 AXL GRB2 NCK2 PMC11700734__F11 Metabolomic and metagenomic analyses elucidate the role of intercropping in mitigating continuous cropping challenges in tobacco VIT TH MYOF TUB CYRIA ABCA2 PC ARC HP ABCG2 EMB PMC8399382__F1 Metabolic Host–Microbiota Interactions in Autophagy and the Pathogenesis of Inflammatory Bowel Disease (IBD) ATG16L1 ATG12 IRGM NOD2 ATG5 PMC4729697__F7 Ingenuity Pathway Analysis (IPA) illustration showing upstream regulation of the pathway for NFKB HDAC3 IL18 TNF NR3C1 PMC5857537__F7 Molecular alterations in cortisol-producing benign adrenal cortical neoplasms MC2R PRKAR1A PMC4743890__F1 Neural circuitry and immunity ACHE NTS TLR4 PMC8945726__F2 Mitochondrial Oxidative Stress and Cell Death in Podocytopathies BAX CASP9 CASP8 BCL2 PMC3461213__F1 Regulatory mechanisms of phosphate homeostasis DMP1 PTH FGF23 PMC3156300__F9 Prolactin-Stimulated Activation of ERK1/2 Mitogen-Activated Protein Kinases is Controlled by PI3-Kinase/Rac/PAK Signaling Pathway in Breast Cancer Cells PRLR PRL GRB2 PMC8600311__F2 Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases S100A4 NR2A1 EPHA2 RHO PMC4865030__F2 Interplay between Fanconi anemia and homologous recombination pathways in genome integrity TOPBP1 ATR RAD51 ID2 BRCA2 UBE2T MCM7 BRCA1 MCM3 ATM MCM5 FAAP24 MCM6 MCM2 PMC8470500__F1 Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders TNF IL1B PMC8470500__F2 Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders CRP NLRP3 TLR4 MIP PMC7283441__F1 Signaling cascade of apoptosis in traumatic brain injury (TBI) BAX BAD FAS PMC7762483__F5 Oxidative stress-induced activation of AP-1 in an ASK1-dependent manner induces TGFB and galectin-9 expression HMGB1 BTK TIRAP TLR4 MYD88 PMC6873206__F1 YAP regulation by mechanical stimuli LATS1 LATS2 PMC9558365__F1 Wnt/Beta-catenin signalling pathway in Haematological Neoplasms APC GSK3B LRP5 LRP6 CTNNB1 PMC9577372__F2 Transforming growth factorB in tumour development CDC42 FOXA1 HMGA2 SMAD2 SMAD4 TGFBR3 ATF2 ARHA TRAF6 TGFBR1 FOXC2 FOXA2 ZEB2 GRB2 TWIST1 PMC8473795__F3 Glycocalyx Impairment in Vascular Disease: Focus on Inflammation NLRP3 VCAM1 IL1B MYD88 PMC3595616__F1 The branched isoprenoid pathway MGA IPP DHCR7 PMC3461213__F4 Overall picture of the physiology of FGF-23 and its role in phosphate homeostasis DMP1 PTH FGF23 PMC7826455__F6 Role of miR‐362 in cervical cancer SMAD2 SMAD4 SPTBN1 PMC2892459__F5 Overlay of IfnB timecourse analysis onto the macrophage pathway using BioLayout Express3D SOCS1 IL15 CD40 CXCL9 FAS TNFRSF1A IFIT2 TAP1 SOCS3 MYD88 STAT1 TIFA TLR7 EIF2AK2 IFNGR1 CASP2 STAT2 IRF1 IRF7 GBP1 TNF CXCL10 TLR3 IRF2 BCL2 TNFSF10 CYBB PMC2518081__F3 The pathways involved in polycystic kidney disease PC CFTR AVP PMC9577372__F7 Transforming growth factorB in tumour development MMP2 PTEN MMP9 PMC2892459__F4 Snapshots from the integrated macrophage pathway diagram PSMD4 PSMD11 FAS HK2 PRKRA HLA-DOA PSMC1 NHLRC1 HLA-DPA1 PSMD7 TNF PSMD2 PSMD13 PSMD1 TRIP12 MAPK14 HLA-DRA SIAH2 IFNAR1 IFNB1 TYK2 PMC9201061__F2 Clinical Manifestations and Molecular Backgrounds of Parkinson's Disease Regarding Genes Identified From Familial and Population Studies LRRK2 SNCA VPS13C PMC5228322__F1 Illustration of the Wnt signaling pathways RHO NLK CTNNB1 PMC7408457__F2 Change in the profile of proteins and mRNAs of molecular factors in the primary tumor of the kidney and its metastatic sites PTEN MTOR INS PMC5996030__F2 Possible autophagy signaling pathways in traumatic brain injury (TBI) TLR4 NQO1 MTOR PMC5858516__F9 HyFS and the Hsp90/Akt/mTOR axis in lung cancer cells ATG101 ULK1 MTOR PMC7819896__F1 Cartoon representing the overview of the pathogenesis of COVID-19 and the potential activity of ruxolitinib JAK3 JAK1 PMC9931120__F11 The working model of how FMDV infection regulates host amino acid metabolism RHEB TSC2 SLC38A8 MTOR PMC2813054__F1 Changes in Akt signaling with differentiation of CD8+ T cells and co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1)-blocked highly differentiated CD8+ T cells KLRG1 PMC8094964__F10 DDIT3 Targets Innate Immunity via the DDIT3-OTUD1-MAVS Pathway To Promote Bovine Viral Diarrhea Virus Replication SMURF1 MAVS DDIT3 MX1 OTUD1 PMC3760546__F4 Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease TF TFPI PLG PMC7921671__F3 Cysteine metabolic circuitries: druggable targets in cancer RHOD CS PMC3760546__F6 Natural inhibitors of coagulation and anticoagulant drugs.TF, tissue factor; VKA, vitamin K antagonists; AT, antithrombin; APC, activated protein C; TFPI, tissue factor pathway inhibitor type-1 TF F2 APC PMC5346233__F2 Targeting Notch signalling pathway regulates angiogenesis in the pathological ovary NOTCH2 NOTCH3 NOTCH1 PMC3533361__F1 GSK3 signaling in neural development CDC42 APC LRP5 LRP6 PTEN DISC1 PMC7921671__F5 Cysteine metabolic circuitries: druggable targets in cancer CIC CTH HEL-S-64p PMC7572318__F3 RIPLET is an essential E3 ligase for RIG-I signaling pathway TBK1 MAVS IRF3 PMC9144507__F2 Metformin and Cancer, an Ambiguanidous Relationship TSC2 IGF1 IGF1R MTOR PMC7402324__F2 WNT Signaling in Melanoma CDC42 ROR2 RHO PMC11379076__F2 MTORC1/2 signaling pathways RHEB MLST8 TSC2 TSC1 ULK1 PTEN DEPTOR ULK2 PMC7402324__F3 Proposed model of the crosstalk between canonical and non-canonical WNT-signaling in melanoma CDH2 CD44 BCL9 SIAH2 ROR2 ARF6 LRP5 LRP6 CTNNB1 PMC11379076__F3 Interaction between mTOR pathway and HCC ACLY TSC2 TSC1 LHB AFP ULK1 YY1 MYC CXCR4 PMC7590211__F3 Opposing modulatory effects of TRIM25 and TRIM47 on TGFBeta-Smad signaling in the GI tract TRIM44 TRIM14 TRIM25 TRIM47 SMAD2 GSK3B SMAD4 PTEN MTOR PMC3942026__F2 Evolution of a Cellular Immune Response in Drosophila: A Phenotypic and Genomic Comparative Analysis SPN ALK TUB EGFR SP7 GCM2 TEP1 DDC RAC1 MYD88 PMC7590211__F4 TRIMs on proinflammatory STAT3 (A) and NFKB (B) signaling cascades in CRC TRIM31 STAT3 TRIM14 CXCL13 SPHK1 RELB USP14 VPS35 CCL19 CCL21 JAK1 TRIM29 REL PMC7590211__F2 Role of TRIMs in the control of p53 tumor-suppressor protein CDH2 APC GSK3B LRP6 CTNNB1 CD44 TRIM28 TRIM24 TRIM25 TRIM67 MDM2 TRIM29 TRIM23 PMC7402324__F1 Simplified scheme of canonical WNT -signaling pathway BCL9 RNF43 MAK APC GSK3B LRP5 ZNRF3 LRP6 CTNNB1 PMC4485451__F1 BCR Signaling Pathway and Small Molecule Inhibitors of BCR Signaling SYK BTK PLCG2 BLNK CD19 LYN MTOR PMC6873206__F4 YAP regulation by focal adhesion signaling LATS1 LATS2 RHO NF2 SRC PMC8641543__F1 Oncogenic factors regulate cancer cell metabolism MAX MTOR MYC PMC9570183__F1 Polyphenols as Potent Epigenetics Agents for Cancer DNMT3B DACT2 APC PMC8641543__F2 Inhibitors of glucose metabolism HEL-S-133P PHGDH HK2 LDHB GPT PMC3185539__F1 Summary of NSP1 inhibition of the innate immune response pathway TBK1 STAT1 TLR3 STAT2 IRF3 PMC7492639__F1 Ozone-mediated effects on intracellular pathways involved in cell injury and inflammation CXCL12 IL25 CGAS NLRP3 KEAP1 IL33 MIF CCL2 PMC7402324__F6 Compounds and antibodies affecting WNT/Beta-catenin-signaling pathway that were investigated in melanoma (preclinical studies, except for LGK974, which is tested in the clinical trial NCT01351103) BCL9 TNKS DKK1 INA APC GSK3B LRP5 LRP6 CTNNB1 PMC8831284__F3 Transcriptome-wide association study identifies novel blood-based gene biomarker candidates for Alzheimer’s disease risk SNX32 YPEL3 NECTIN2 INCA1 TP53INP1 XYLT1 TAF6 NRF1 EPHA1 ZNF232 TRAPPC6A PMC5427281__F8 Model depicting the mechanism of phagocyte priming by apoptotic cells CRK RAC1 PMC5059336__F3 miRNAs modulation in direct cardiac reprogramming TBX5 GATA4 HAND2 PMC2965861__F1 The AMPK pathway in relation to various molecules TSC2 STK11 FASN MTOR PMC3129516__F2 SIRT3 and Cancer: Tumor Promoter or Suppressor? SIRT3 TRPM2 NAMPT PMC7576205__F6 Inhibiting insulin and mTOR signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma RPTOR RPS6 AXL RPS6KB1 IGF1R GRB2 MTOR GAB2 IRS1 PMC8268497__F2 Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development SUFU PTCH1 SHH SMO GLI3 PMC8268497__F3 Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development SMAD4 ARHA MTOR PMC2703803__F1 The Heme Biosynthetic Pathway of the Obligate Wolbachia Endosymbiont of Brugia malayi as a Potential Anti-filarial Drug Target CPO UROD UROS PMC4435535__F1 Notch signaling as a novel regulator of metabolism STAT3 FASN PCK1 PMC4435535__F2 Notch signaling as a novel regulator of metabolism TG PRDM16 UCP1 PPARGC1A IL1B PMC10474053__F3 PI3K-AKT pathway and major upstream effectors in the signaling network RHEB TSC2 BAD RICTOR TSC1 INPP4B GSK3B PTEN PMC9556862__F1 Using Clustered Regularly Interspaced Short Palindromic Repeats gene editing to induce permanent expression of fetal hemoglobin in Beta-thalassemia and sickle cell disease: A comparative meta-analysis HBG2 HBG1 CHD4 KLF1 BCL11A PMC4905314__F1 ER stress induced by oncogenic BRAF and modulation of basal autophagy in melanoma ATF4 MTOR EIF2A TRAF2 EIF4E PMC6396338__F6 Contrasting strategies for disrupting interferon (IFN)-mediated responses in hepatitis A virus (HAV) versus hepatitis E virus (HEV) infections MAVS TLR3 STAT2 IRF3 TYK2 PMC8891817__F18 Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling TRIM31 COL1A1 NLRP3 GCLM SMAD2 NQO1 GCLC CXCL10 IL1B PMC10474053__F6 Ca2+-mediated inhibition of membrane localization of PIP-binding proteins PLN TSC2 TSC1 GSK3B MCU PMC10474053__F5 Dysregulation of Ca2+ channels and pumps in metabolic diseases PLN STIM1 CRTC2 TFEB MCU PMC5834520__F1 Osteopontin in the progression of solid organ tumour BAX DSPP DMP1 PMC7699570__F2 Signaling targets of CO HMGB1 EGR1 NLRP3 PMC5834520__F2 Osteopontin in the progression of solid organ tumour CD44 EGF EGFR PTEN HIF1A PMC11660139__F8 Inhibition of miR-675 on TGFB signaling and OC progression SMAD2 SMAD4 PMC9355713__F3 Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism NLRP3 KEAP1 ATF4 PMC3100753__F4 Regulation of the estrogen signaling pathway inside the nucleus PELP1 CTBP2 PMC5441870__F3 Central metabolism of T NAPA RTCA NDP PMC4904747__F16 JAK STAT pathway STAT1 JAK1 PMC3272176__F1 Signal Transduction pathways downstream of activated HER family of receptors PTEN MTOR CCND1 PMC5805715__F4 The gene targets of miRNA identified by NGS in the AIS patients and their role in osteoblast and osteoclast differentiation depicted from KEGG and DIANA miRPath v3 SMAD1 DKFZp781O1323 SMAD2 APC GSK3B CTSK SP7 SMAD4 RUNX2 FGF2 NFIA CTNNB1 BMP4 BMP2 PMC11018134__F7 FBL Promotes LPS-Induced Neuroinflammation by Activating the NFKB Signaling Pathway FBL CD14 MYD88 PMC9311231__F3 Metabolic assessment of tumors reveals alternative pathways for Trp catabolism OGDHL CYP1B1 PMC5984668__F1 STATus of STAT3 in Psoriatic Arthritis STAT3 CCR6 AHR CCR4 TNF CCR10 PMC6429030__F2 TLR2/IFN-λ3 protein-protein interaction was performed by using String software STAT3 IL10 IFNL3 IL4 IL6ST IL6 PMC8472352__F2 New Functions of Vav Family Proteins in Cardiovascular Biology, Skeletal Muscle, and the Nervous System VAV2 PAK1 ARHA SRC RAC1 PMC5756134__F2 An Unexpected Friend – ROS in Apoptosis-induced Compensatory Proliferation: implications for regeneration and cancer AIP PMC7962738__F2 Glutamine synthesis, nucleotide biosynthesis, and the pentose-phosphate pathway HEL107 CAD CTPS2 RRM1 RRM2 CMPK1 TYMS ADSL RPE PAICS PNP CTPS1 DTYMK UCK1 TK1 OMP GUK1 AK2 UCK2 UMPS PFAS TYMP PMC8811913__F6 Transition Toward Nitrogen Deprivation in Diatoms Requires Chloroplast Stand-By and Deep Metabolic Reshuffling HEL107 NREP PMC7962738__F1 Glycolysis, gluconeogenesis, glycogen metabolism, the hexosamine pathway, oxidative phosphorylation, and the TCA cycle OGT FH CS MPC1 MPC2 PCK1 PGAM1 PDK4 HEL-S-68p OGDH HEL-S-49 HEL-S-162eP FBP1 PC PFKL HEL-S-87p PMC7544648__F1 Mechanisms of alcohol-induced microglial eCIRP in promoting AD pathology STAT3 HMGB1 CDK5 NLRP3 TLR4 JAK1 PMC5403593__F3 Cartoon illustrating two independent parallel pathways in the post-mitosis G1 phase (G1-pm) in cell proliferation: MAPK and the Hippo pathways LATS1 LATS2 EGFR YAP1 PMC3422784__F5 Sensing the environment: Regulation of local and global homeostasis by the skin neuroendocrine system TPH1 CYP2C19 AANAT TPH2 ME1 NAT1 PMC3541667__F5 Hypothetic model explaining how KDM6 may contribute to definitive endoderm differentiation KDM6B DKK1 WNT3 CTNNB1 PMC6958404__F1 Major Signalling Pathways Involved in Hepcidin Regulation STAT3 SMAD1 TFR2 DKFZp781O1323 SMAD6 SMAD4 EPO HFE2 ERFE POR BAMBI BMP6 TWSG1 GDF15 HFE JAK1 TMPRSS6 PMC5403593__F2 Cell cycle phases and two examples of independent core pathways in the G1 stage GIP YAP1 CTNNB1 PMC4846832__F6 Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury TLR4 IRAK1 MYD88 PMC7543703__F2 NSAIDs inhibit the synthesis of prostaglandins that protect against COVID-19 COX1 PMC8602059__F1 Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma LTBR TRADD RELB TAB3 TRAF3 TRAF6 VCP MYD88 MAP3K7IP1 OTUD7B TNIP2 TRAF5 TRAF2 CYLD PMC6850914__F1 Signal transduction pathways initiated by IL‐29 STAT2 IRF9 NFATC1 JAK1 TYK2 PMC6525179__F5 Gene expression and 14C fatty acids production in LC-PUFA synthesis pathway of liver between knockout (KO) and wildtype (WT) salmon ELOVL4 ELOVL2 CPM PMC6854382__F10 Study on the mechanism of the MPAPO promoting of corneal wound repair and axonal regeneration (A) MPAPO activates the classic Wnt/Beta-catenin signaling pathway through the PAC1 receptor CDK6 BCL2 CDK4 CTNNB1 PMC8113731__F1 Mitotic kinases as drivers of the epithelial-to-mesenchymal transition and as therapeutic targets against breast cancers NEK2 GSK3B PMC4508581__F4 Model illustrating the relationship between hypoxia, ER stress, and activation of the unfolded protein response ATF4 EIF2A XBP1 PMC2788213__F4 Systems-Level Comparison of Host-Responses Elicited by Avian H5N1 and Seasonal H1N1 Influenza Viruses in Primary Human Macrophages SPN MAVS TLR3 PMC3536147__F3 Identification of Burkholderia cenocepacia Strain H111 Virulence Factors Using Nonmammalian Infection Hosts PURA PURB PMC9638168__F2 MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring KLF4 STAT3 BAX TIMP3 MAK TMEM9B ABO SMAD6 PPP2CA IL6ST MMP9 PMC6185734__F9 Magnetic fields affects microtubules via EGFR and calcium pathways EGF EGFR MARCKS PMC7849182__F8 Schematic showing multiple signaling pathways of HSYA F2 TLR4 GRB2 MTOR MYD88 PMC8447736__F4 Bioinformatics analysis of SARS-CoV-2 infection-associated immune injury and therapeutic prediction for COVID-19 MME SELE MAK ELL CASP3 MMP3 TNF FADD PMC12151402__F1 Proposed effect of CHEK2 loss of function on cytotoxic T-cell recruitment at different organizational levels ATR CGAS CHEK2 ATM IRF3 PMC8147131__F7 Metformin Dysregulates the Unfolded Protein Response and the WNT/Beta-Catenin Pathway in Endometrial Cancer Cells through an AMPK-Independent Mechanism ATF4 CTNNB1 PMC11502721__F2 Intestinal homeostasis by microenvironment STAT3 EGF NRG1 TGFB1 DGAT2 MMP17 AHR RSPO3 CTNNB1 RSPO1 PMC8447736__F5 Bioinformatics analysis of SARS-CoV-2 infection-associated immune injury and therapeutic prediction for COVID-19 POR PMCH OXT VIP MLX CRH LEPR SI NMU DAO PMC11502721__F3 Intestinal stem cells (ISCs) by glucose, fatty acid, and ketone body metabolism HK2 FASN MPC1 CPT1A PMC5627579__F3 Proximal tubule (PT) phosphate reabsorption XPR1 PTH FGF23 PMC4683444__F4 Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity BAX BAD CSF2 IL3 TNFSF6 AKT3 NGF BCL2L1 CSF2RB NTRK1 DFFA BCL2 ATM BIRC2 PMC9562620__F9 Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NFKB signaling pathway COX2 TNF IL1B PMC5448108__F7 A proposed model for the regulation and function of two Grp78 genes in JH-stimulated locust vitellogenesis MCM7 EIF2A SRC PMC3837055__F1 Schematic view of kallistatin action in the canonical Wnt pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC5239457__F7 EIF2A serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress LATS1 WWP1 LATS2 FOXO1 ATF4 EIF2A PMC10215824__F3 Obesity-altered adiponiche and tumour development: some novel proposed mechanisms in mature adipocytes and precursor cells TF VEGFC MTOR TNF CD34 PMC9647059__F1 Neuroinflammation in retinitis pigmentosa: Therapies targeting the innate immune system SOCS1 STAT3 IL1R1 NLRP3 EDN2 IL16 LIF EDNRB SOCS3 CCL2 MYD88 PMC3192015__F1 Mammalian target of rapamycin, Akt, and phosphatidylinositol 3-kinase signaling RHEB MLST8 TSC2 RICTOR EIF4E PMC2684375__F1 Factors involved in the regulation of corporal smooth muscle tone GC CNP RHO PMC4980583__F5 Thumbnail image of MAPK signalling pathway MAX NLK TRAF6 TNF FLNA PMC5100880__F6 Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer BAD CDK2 BCL2 PTEN MDM2 PMC5345976__F10 Scheme summarizing the protective effects of Xn on LPS-induced acute lung injury via activation of the AMPK/GSK3Beta-Nrf2 axis NLRP3 TXNIP GSK3B IL1B PMC5100880__F7 Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer BAD CDK2 BCL2 PTEN MDM2 PMC9301183__F1 NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes GSDMD NLRP3 ACE2 IL1B PMC6030217__F1 Role of NUAK1 in anti-oxidant signalling NUAK1 KEAP1 GSK3B MYC PMC8018950__F3 Top regulatory effect predicted by Ingenuity Pathway Analysis within Fayoumis at 6 dpi comparison ABCG1 IL33 MAPK9 IRF8 FOXP3 NFIL3 FOS PMC5095680__F4 Impact of miR-140 overexpression on proteins involved in the NFKB signaling pathway ADAMTS4 ZFP91 ADAMTS5 IL6 IL1B PMC5382464__F1 Significantly up-regulated genes during analysed training periods in Arabian horse blood that belong to the FoxO signalling pathway (KEGG ecb04068) STAT3 EGF EGFR SMAD4 BNIP3 IL7R PTEN INS SKP2 SIPA1 ATG12 INSR CDK2 ATM NLK MDM2 PMC5784915__F6 Inferring hidden causal relations between cancer and normal networks HTRA2 BAD STK11 RPS6KA2 RPS6KB2 CYCS GSK3B RPS6KA1 FBXW11 BNIP3 MTOR PRKAA1 MAPK6 MAPK3 BCL2L1 CAMKK2 BTRC USP1 HEL-S-1 DUSP16 YWHAG MAPK1 RPTOR EIF4B RHEB RBX1 RICTOR PRKDC PRKAA2 PRKAG1 CASP3 MAP3K7 BCL2 PRKAB1 RPS6KA3 YWHAZ PMC9617413__F4 Transcriptomic and metabolomic analyses for providing insights into the influence of polylysine synthetase on the metabolism of Streptomyces albulus SDHB DAP PMC9233553__F2 Coronaviral PLpro proteases and the immunomodulatory roles of conjugated versus free Interferon Stimulated Gene product-15 (ISG15) IFNG USP18 ISG15 TYK2 PMC5784915__F7 Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks HEL164 AURKA VRK1 PCNA CCNA2 BLM CKAP2 FOXM1 CDKN2C CDCA8 SPAG5 CCNB1 CDC2 DBF4 ESPL1 FEN1 ECT2 DTL RRM2 KNTC2 CDCA3 AURKB CDCA7 CEP55 MCM2 CDC25B PMC10845297__F3 Fibroblasts of metastatic organ in PMN formation TNFAIP3 FAP CCR8 CCL1 PMC4745841__F7 Functional interpretation of the IL-6 gene signature and its relationship to the three main downstream pathways of IL-6.Notes: The 17 genes are part of the Jak-STAT IL-6 downstream pathway STAT3 S100A7 IFITM2 EBP SERPINA3 S100A8 IFITM1 AKR1C1 CEBPD IFITM3 AKR1C2 TMC5 LCN2 S100A9 GBP2 PMC6099083__F5 Tumor Epigenetically Upregulated Genes (EUG) in Epstein-Barr Virus Infection pathway CD44 CD40 IFNG STAT3 IL10 NEDD4 JAK3 IRF3 MDM2 TBP TRAF6 PMC10085880__F7 In silico identification of potential miRNAs -mRNA inflammatory networks implicated in the pathogenesis of COVID-19 SYK ADAR IL10 NLRP3 TLR3 STAT2 IRF9 IRF3 TRAF3 PMC9265283__F5A Tissue-Based Proteomic Profiling in Patients with Hyperplasia and Endometrial Cancer HEL107 KRT10 ACTG1 HEL-S-68p tmp_locus_29 CCT4 EEF1A1 HEL-S-165mP HEL-S-30 PMC3826456__F2 Diagram of PI3K/Akt and Ras/Raf pathway (see text for details) RHEB TSC2 TSC1 EGFR IRS1 PMC2670830__F4 Signaling in pterygium JUN EGR1 BTG2 APOE USF1 SPARC SP3 DKFZp686P11128 CSTA FOS PMC2932530__F9 Redox regulation of the PI3K/Akt signaling pathway BAD PI3 PTEN PMC2733082__F2 InterferonG signaling pathway and mutations in its components found in human uterine leiomyosarcoma STAT1 IRF1 JAK1 PMC8739172__F4 Exploring the Mechanism of Panax notoginseng Saponins against Alzheimer's Disease by Network Pharmacology and Experimental Validation SLC3A2 RICTOR GHB2 RHO GRB2 MTOR TNF PMC6836530__F8 Schematic diagram of the molecular mechanisms underlying NOTCH2-regulated EMT NOTCH2 TRAF6 PMC8465509__F2 Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics STAT3 BAX EGFR MTOR SRC PMC9399684__F2 Modulation of ion channels in cancer chemo-resistance KLF4 CD44 BAX BAD TRPV2 SOX2 GSC MDM2 CTNNB1 PMC2525561__F4 Schematic diagram of in vivo n3 VLC-PUFA biosynthetic pathway mediated by ELOVL4 and other ELO families [modified after Suh and Clandinin ()] ELOVL4 ELOVL3 ELOVL2 ELOVL1 ELOVL5 PMC5485329__F3 AMPK and mTOR pathway by Sestrins TSC2 TSC1 ULK1 MTOR NOX4 PMC5382464__F2 Significantly up-regulated genes during analysed training periods in Arabian horse blood that belong to the PI3K-Akt signalling pathway (KEGG ecb04151) SYK BAD RBL2 PTEN CD19 MTOR RAC1 EIF4E RHEB TSC2 BCR PI3 RXRA MEI1 CDC37 MDM2 PMC6593125__F1 T-cell receptor (TCR) signaling LAT CSK GRB2 LCK PMC4741479__F4 Radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas DNMT3B MYB SP1 MCL1 CD40LG SMC1A VEGFA WT1 CDK6 CDKN1A BCL2 ATM FLT1 KDR MDM2 CCND1 CDK4 PMC7310461__F4 Alterations in TCR signaling pathway GRAP2 CD3D ZAP70 PIK3CA RAF1 PDCD1 VAV2 NFATC2 CARD11 PIK3CD PIK3R2 GSK3B PIK3R1 PTPRC PPP3CA PPP3CC IFNG TEC FYN BCL10 PDPK1 NRAS CSF2 NCK1 VAV3 CD8B1 VAV1 CTLA4 TNF FOS HRAS ICOS PRKCQ SOS2 PAK1 MAP3K7 GRB2 CDC42 MAPK13 LAT PIK3R3 PPP3R1 PAK4 IKBKG PLCG1 NFKBIE CHUK IL2 CDK4 IL10 JUN LCP2 IL4 NFATC1 CD40LG PPP3R2 IL5 PTPN6 KRAS NFKB1 IKBKB RELA NFKBIA MAP2K2 NFATC3 CD3G CD8A NFKBIB LCK PMC7310461__F5 Alterations in the BCR signaling pathway SYK PIK3CA CD79B CD79A RAF1 SOS1 VAV2 CD72 NFATC2 CARD11 RASGRP3 PIK3CD PIK3R2 GSK3B PIK3R1 CD22 CR2 PPP3CC BCL10 PLCG2 LILRB5 LILRB1 FCGR2B VAV3 IFITM1 FOS LILRA4 HRAS DAPP1 SOS2 GRB2 PIK3R3 PPP3R1 RAC3 IKBKG PRKCB BTK LILRA2 NFKBIE CHUK LILRA6 LILRA1 LILRA3 CD81 JUN BLNK CD19 NFATC1 NPAT PPP3R2 KRAS RAC1 LILRB2 NFKB1 IKBKB RELA LILRB4 NFKBIA INPPL1 LYN NFATC3 NFKBIB PMC11958781__F9 Mechanistic diagram illustrates that KLF6 cooperates with FOSL2 to promote H3K23su levels and enhance 5-FU resistance in HCT15-FR cells FOSL2 SEMA3C RAC1 CTNNB1 PMC4077717__F1 Overview of the general innate immune response to viral infection TBK1 CGAS MAVS IRF9 IFIT1 IFITM1 PML IRF3 IFI16 IRF7 RSAD2 MYD88 STAT1 TLR3 IFNAR2 IFNAR1 CH25H MX1 ISG15 JAK1 OAS1 TYK2 IL10RB PMC8555304__F3 Chemoprotective and chemosensitizing effects of apigenin on cancer therapy BAX BAD KEAP1 MEI1 TNF PMC1885990__F1 Scheme depicting a molecular pathway by which cell-cycle-related molecules promote cell death in neurons in development and disease HDAC1 E2F4 SUV39H1 CDK4 PMC3096978__F4 Functional network connections between HRneg/Tneg signature genes MAPK1 STAT3 CLIC5 EXOC7 IL10 CXCL13 MAPK11 SP1 CCL3 HAPLN1 EEF1G ACTA1 TNF IFNG RPS28 CCR7 RGS4 PMC7310461__F3 Alterations in SLE signaling pathway based on calculated final parameters H2BC12 CD40 C6 CD80 HLA-DOA HLA-DPB1 CTSG IFNG SNRPB C9 H3C15 H3C8 H2AC21 HLA-DQA2 H4C9 C7 TNF HLA-DOB HEL-S-62p HLA-DRB1 C1R HLA-DPA1 C4A HLA-DRB5 HLA-DRA SNRPD1 ELANE HLA-DRB4 C4B_2 FCGR2A HLA-DMB C8G IL10 H2AC14 HIST1H2AB HIST1H2AK H2AJ C1S H2BC14 H2BC15 H2BC11 HIST1H2BE CD40LG MACROH2A2 FCGR1A H2BFM HLA-DQB1 H2BW1 H2BC9 H2AZ1 H4C7 H2BC8 HLA-DMA H3F3B H2BC3 H3-5 FCGR3A C8A HLA-DRB3 PMC6687721__F7 The synergistic effects of oxaliplatin and piperlongumine on colorectal cancer are mediated by oxidative stress BAX CASP9 CASP3 ATF4 EIF2A PMC2151384__F2 CON and NR samples; black/white boxes denote genes not detected on the human genechip with baboon RNA generated probe RHEB STAT3 TSC2 EIF4B RICTOR TSC1 LEPR HIF1A MTOR EIF4E PMC9090500__F7 Rapid Inflammasome Activation Is Attenuated in Post-Myocardial Infarction Monocytes NLRP3 TNFAIP3 IL18 PMC9362342__F1 Cellular senescence and the SASP BMI1 ATR ETS2 FOXO3A CXCL1 ATM MDM2 MTOR GATA4 CDK4 PMC3326643__F2 Targeting Mnks for Cancer Therapy RHEB TSC2 EIF4B TSC1 NF1 PTEN ELF3 IRS1 EIF4E PMC8932957__F2 Conserved nutrient-sensing response pathways in worms, flies and mammals EGR1 IGF1 TFEB MYC PMC8052137__F6 Underlying Molecular Mechanisms Involved in Traditional Chinese Medicine Smilax china L. for the Treatment of Pelvic Inflammatory Disease STAT3 PGR PLAUR PTGS2 MMP9 TNF SLC22A6 MPO ALB HSPD1 MMP2 IL2 LCN2 CYP3A4 ABCC2 ABCB1 PMC12029909__F5 Screening for maps of metabolic pathways involved in key differentially expressed metabolites MAL APP CIT PMC6718556__F5 Several metabolic mechanisms may provide an advantage to Tregs in the tumor microenvironment FAS CD36 GCK PMC6533481__F7 The molecular mechanism involved lncRNA MEG3 affecting the fraction healing of mice after tibia fracture WNT10B GSK3B EZH2 COL10A1 RUNX2 CTNNB1 PMC8554124__F9 Systematic Review of Transcriptional Dysregulation in Huntington’s Disease Studied by RNA Sequencing HEL-S-103 DNAJB1 HEL-S-102 PMC9656133__F6A Integrated Multi-Omic Characterization of the Detachment Process of Adherent Vero Cells with Animal-Based and Animal-Origin-Free Enzymes LAP3 PMC2743781__F3 NAD biosynthetic pathways from nicotinamde and nicotinic acid in yeast, invertebrates, and mammals NMNAT1 NAMPT NMNAT2 NMNAT3 PMC6549095__F7 Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NFKB expression AXL MMP2 MMP9 PMC8451004__F4 Integrated analyses of long noncoding RNAs and mRNAs in the progression of breast cancer SYK MYB TSC2 BAD BCR RBL2 CD19 PTEN MDM2 RAC1 PMC10741662__F1 WNT/Beta-catenin signaling pathway APCDD1 APC LRP5 LRP6 CTNNB1 PMC3546740__F2 Simplified schematic overview of the biosynthesis of the main secondary metabolites stored and/or secreted by tomato glandular trichome cells IPP FAS HEL-S-5 STS PMC2889494__F3 Protein components of the pheromone response network constructed by the PCST approach TF SWI5 ORC6 ARAP1 CCR4 ACE2 PMC8894239__F3 mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment TLR1 TGFB1 POLI PTEN FOXP3 GCK PMC9311918__F1 mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases RHEB BAX TSC2 PINK1 TSC1 TFEB ATG14 ATF4 BNIP3L PMC8894239__F1 mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment RHEB TSC2 TSC1 FOXO3A PTEN DEPTOR PMC9311918__F3 mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases MLST8 MTOR DEPTOR IRS1 PMC11668900__F1 Mechanisms affecting gastric epithelial cell plasticity CDC42 CDH2 ARHH SNAI2 SMAD2 DLL4 APC LRP5 SMAD4 LRP6 MYC CTNNB1 CD24 KIF7 PTCH2 DKK1 SUFU PTCH1 SMO CXCR4 DLL3 GLI3 PMC6829565__F6 Schematic diagram depicting the MAPK/ELK1 signaling pathway linking Ang II-RBM20-titin splicing RBM20 TTN PMC8583510__F5 Mitochondria as a Cellular Hub in Infection and Inflammation ECSIT MAVS TANK TLR9 IRF3 IRF7 TRAF3 DHX58 TRAF6 MYD88 TLR1 GSDMD NLRP3 TLR3 TLR4 IL18 TLR8 TLR7 PMC3127159__F2 TPO signaling pathway BCL2 TPO PMC12050339__F7 Molecular pathways involved in the mechanism of mLV injury PROX1 PIEZO1 VEGFC FOXC2 CX3CR1 PRDM1 EGFR XLKD1 PMC6298397__F3 Central metabolic pathway of representative carbon sources in model iZBM1060 (detailed information on enzyme information and reactions are presented in Supplementary Table ) ME2 MAL GIP KDR CIT PMC5932555__F2 Design and application of scaffold RNAs controlling both genomic target sequence and regulatory function MXI1 CP PMC9687450__F5 UPLC-QTOF/MS Metabolomics and Biochemical Assays Reveal Changes in Hepatic Nutrition and Energy Metabolism during Sexual Maturation in Female Rainbow Trout (Oncorhynchus mykiss) TG PC BIK PMC8582418__F3 Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment GLS FASN PMC4110160__F1 Differential LSEC Signalling in Models of Acute or Chronic Injury HGF FGFR1 CXCR4 PMC3880197__F2 Reactive oxygen species in cancer PTEN SRC RAC1 PMC11056316__F9 Schematic illustration outlining the mechanism by which PIN operates during osteoclastogenesis ATP6V0D2 NFATC1 MMP9 TRAF6 RAC1 ACP5 PMC8623999__F7 Exercise Training Alleviates Cardiac Fibrosis through Increasing Fibroblast Growth Factor 21 and Regulating TGFB1-Smad2/3-MMP2/9 Signaling in Mice with Myocardial Infarction FGF21 SMAD2 MMP2 MMP9 PMC7843416__F1 Type I interferonopathy-associated genes are involved in the sensing and metabolism of viral RNA RNASET2 TREX1 PMC2810486__F1 The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections TIRAP COX2 IL16 TLR4 IL6 TRAF3 MYD88 PMC8395241__F7 Analysis of PPARG Signaling Activity in Psoriasis IL17F STAT3 PPARG JUN STK11 EGFR TICAM2 IL17A TRAF6 KRAS FOS MYD88 IL-21 TSC2 RORC MAP3K1 PDPK1 TICAM1 MAP3K7 MAP2K1 SRC PMC5497685__F1 Ca2+ regulates different steps of autophagy TRPM2 ULK1 PI3 TFEB HEL-S-11 MTOR PMC4096794__F8 Sumoylation Pathway Is Required to Maintain the Basal Breast Cancer Subtype FOXA1 TFAP2A TFAP2C PMC7689098__F1 KLF9 regulates cAMP signaling pathway genes in HT22 cells JUN RAF1 TIAM1 VAV2 RAP1A ARHA RHO AMH BDNF FOS PMC7689098__F2 KLF13 regulates cAMP signaling pathway genes in HT22 cells JUN RAF1 TIAM1 VAV2 PAK1 RAP1A ARHA RHO AMH BDNF FOS PMC3720582__F1 Comprehensive Hedgehog Signaling Pathway FAS HHIP ITCH BOC DHH IHH NUMB TCF4 SKI RUNX3 PTCH2 CCND2 SUFU PTCH1 SHH SMO NOTCH1 GLI3 PMC3720582__F2 Structural and Logical Analysis of a Comprehensive Hedgehog Signaling Pathway to Identify Alternative Drug Targets for Glioma, Colon and Pancreatic Cancer HHIP ITCH BOC DHH IHH NUMB TCF4 SKI RUNX3 SNAI1 PTCH2 SUFU PTCH1 SHH BCL2 SMO GAS1 PMC6038002__F10 Tim‐3 exacerbates kidney ischaemia/reperfusion injury through the TLR‐4/NF‐KB signalling pathway and an NLR‐C4 inflammasome activation NLRC4 TLR4 TNF PMC7689098__F9 Proposed model for the repressive actions of KLF9 and KLF13 on cAMP-dependent neurite-outgrowth RAF1 RAP1A KLF9 KLF13 PMC4121837__F6 Proposed model for 18-5p–mediated inhibition of viral reactivation through the MAPK signal transduction pathway MAP3K2 BCR RAC1 PMC8123704__F5 Dipterocarpus tuberculatus Roxb. Ethanol Extract Has Anti-Inflammatory and Hepatoprotective Effects In Vitro and In Vivo by Targeting the IRAK1/AP-1 Pathway IRAK1 IRAK4 IL1B MYD88 PMC3032466__F11 Expression of cell cycle genes in wild-type (WT) and CKX-4 tubers after GA3-mediated tuber sprouting CDC20 APC WEE1 PMC8305988__F4 Personalized Genomics Approach of the Prostate Cancer CASP9 BAD EGFR AKT3 PTEN MMP9 MTOR CTNNB1 CDKN1A CDKN1B NFKBIA CREBBP CHUK MDM2 CREB1 PMC3679038__F7 Involvement of ERK-Nrf-2 Signaling in Ionizing Radiation Induced Cell Death in Normal and Tumor Cells MAFK KEAP1 GCLC PMC9133881__F5 miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network DKK4 BMP4 BMP2 PC FGF20 EDARADD HEL-S-30 EDAR TNLG7C CTNNB1 CIT PMC6566851__F5 Effect of butyrate on the Wnt signaling pathway Butyrate can increase Wnt1/2/3 expression, which bind to their receptor Fzd to activate Wnt signaling pathway WNT1 WNT3 CTNNB1 PMC9005359__F5 Risk-Related Genes and Associated Signaling Pathways of Gastrointestinal Stromal Tumors ATR HIPK2 HLA-G HEL-S-69p MRC2 ATM GATA4 PMC12090635__F2 EMT and Notch signaling pathway STAT3 ACTL6A KIAA1217 ADAM10 TSPAN5 C6orf79 RNF187 NOTCH1 PMC6566851__F8 Crosstalk of signaling pathways under butyrate influence STAT3 BAX FAS RAC1 PMC12090635__F1 Composition and activation of Notch signaling pathway DLL4 JAG2 DLL3 PMC4850467__F1 Different compounds in cigarette smoke regulate EMT AHR PAH SRC PMC8399643__F3 Regulatory roles of aminoacyl-tRNA synthetase in cardiovascular disease SP1 SP2 ATF4 XBP1 PMC2914561__F1 Translation control of gene expression AGO1 MTOR EIF2A EIF4E PMC6474359__F2 IL-17 family of cytokines in health and disease IL17RC SYK BAD CAD ARID5A TRAF5 TRAF6 TRAF2 PMC9658645__F3 Monocyte, a Maestro in the Tumor Microenvironment (TME) of Breast Cancer EGF CXCL17 CCL18 CSF1 SPARC VEGFA PITPNM3 PMC6679138__F3 Proposed model for the cellular response to complex DNA damage (CDD) induced by proton beam therapy (PBT) in chromatin RNF20 MSL2 PMC9062296__F8 Endolymphatic Hydrop Phenotype in Familial Norrie Disease Caused by Large Fragment Deletion of NDP FZD4 TSPAN12 LRP5 PMC8569703__F1 Contextual Essentiality of Mitochondrial Genes in Cancer FAM36A TFB2M GFER MRPS6 TRIAP1 LETM1 FXN ISCU CHCHD4 CYCS COQ2 SLC25A3 CS DHODH BCL2L1 PC TOMM40 HEL-S-44 PTPMT1 DUT TFAM UQCRFS1 FES NDUFA2 PPA2 PRODH SDHC PMC8299562__F2 Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies FGF8A STAT3 CAMKK2 LEPR NPY SOCS3 MTOR EIF4E PMC6108178__F3 Primary myelofibrosis based on results obtained in animal models MPL TPO PMC5476263__F2 Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes FANCD2 ATR FEN1 HLTF ATM FAN1 BLM PMC4890621__F2 BIOPROSTHETIC HEART VALVES OF THE FUTURE CRP CD44 ICAM2 PIGS CD34 PMC11952772__F2 Lactobacillus regulate skeletal muscle pathways through short-chain fatty acids FFAR3 IGF1 MTOR FFAR2 PMC11952772__F1 Possible mechanism of Lactobacillus alleviating sarcopenia TLR4 IMPACT PMC4861839__F1 Inositide signaling pathway and target agents used to treat gastric cancer and colorectal cancer TSC2 RICTOR TSC1 PTEN MTOR PMC6463672__F8 LINC01354 and Wnt/beta-catenin signaling pathway MMP7 HNRNPD TCF4 CTNNB1 PMC7903614__F6 Primary paracrine and autocrine signalling contributes to cholesteatoma pathogenesis upon activation of the TLR4 pathway EGF EREG HGF TLR4 CXCL5 IGF2 IL1B PMC8353874__F2 Triple-negative breast cancer: understanding Wnt signaling in drug resistance STAT3 EGF EGFR MUC1 TWIST2 PTEN GATA6 GRB2 MTOR TWIST1 CTNNB1 PMC8353874__F1 Triple-negative breast cancer: understanding Wnt signaling in drug resistance CDC42 CD44 EGFR APC GSK3B LRP5 LRP6 ARHA CCND1 DAAM1 CTNNB1 PMC10037512__F6 Mechanism of STX5 involvement in HCC metastasis STX5A CAD MTOR PMC6027047__F1 Metabolic activation of aristolochic acid I (AA-I), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 5-methylchrysene, and tamoxifen are shown as prototypes of procarcinogens POR IDE NQO1 PHIP PMC5562846__F1 Simplified scheme of chromatin changes in response to double-strand break (DSB) occurrence highlighting a central role of the ATM kinase RAD50 MRE11A RNF168 RNF8 ATM MDC1 PMC8862475__F7 Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas HEL-S-5 MTOR CIT PMC7803748__F4 Muscle atrophy and hypertrophy: implications in health and disease TRADD TRAF6 TRAF2 IRS1 PMC7803748__F1 Muscle atrophy and hypertrophy: implications in health and disease UBE4B PSMD11 GABARAPL1 FBXO31 PSME4 ULK1 BNIP3 MTOR IRS1 RHEB USP14 TSC2 RICTOR TSC1 IGF1 PMC7803748__F2 Muscle atrophy and hypertrophy: implications in health and disease SMAD1 DKFZp781O1323 GDF11 SMAD2 SMAD6 SMAD4 BMP7 MTOR PMC8024302__F4 Effect of extracellular vesicles on the regulation of mitochondria under hypoxia NLRP3 TLR9 IL1B MYD88 PMC8024302__F5 Effect of extracellular vesicles on the regulation of mitochondria under hypoxia ULK1 MFN2 HIF1A MFF PMC2952980__F1 Multifactorial pathway leading to gastric carcinoma SIM1 TLR4 IL1B PMC3548018__F2 Integrated scheme for MIF expression, signal transduction and regulation of glucocorticoid immunosuppression and cell survival CD44 CD74 MAPKAPK2 MIF IL8RB SRC CXCR4 TNF PMC8533092__F1 Non-Alcoholic Fatty Liver Disease in Lean and Non-Obese Individuals: Current and Future Challenges PNPLA3 TM6SF2 IL33 SREBF2 IL1B PMC8851862__F3 Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat CDC2 ATR RAD51 CDK6 DNA2 NEK11 CDK2 ATM NUDT16L1 SSB CDK4 PMC5643752__F1 Schematic representation of Nrf2 and Keap1 protein domains KEAP1 MAF PMC9634729__F1 Targeting DNA damage response as a potential therapeutic strategy for head and neck squamous cell carcinoma MSH2 MSH3 BRCA1 SSB XPC PMC5643752__F2 Hinge-latch model of Nrf2 JUN KEAP1 NQO1 MAF PMC4905289__F2 TGFB signaling TGFBR2 CRIPTO TGFBR3 SMAD4 MSI2 HEL-S-89n PMC5629438__F3 Intracellular and Extracellular mode of Toll‐like receptor (TLR) signalling pathways: signalling heterogeneity in TLR pathways arises from the differential recognition of pathogen‐associated molecular patterns (PAMPs) by different TLRs TBK1 TIRAP TAB3 MAL TLR9 CD14 IRAK1 TLR5 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC4086146__F1 Schematic model of mammalian heme homeostasis BACH1 FECH PMC11755879__F1 Molecular mechanisms of NLRC5 regulation of NFKB and type I IFN pathways and MHC I gene expression TBK1 STAT1 MAVS RFXANK IRF1 IRF3 JAK1 PMC11755879__F2 Functions of NLRC5-dependent domains SPN STAT3 SIN3A FABP4 IRF3 CCND1 PMC2900209__F6 Inflammation Stages in the Acute Lung Injury in Mice JUN RAF1 MAP4K1 TNF TRAF6 MAP3K2 MAP2K4 MAP2K6 RASA2 NFKB1 PAK1 CRTAP FGFR1 DDIT3 MAP2K1 MAP2K2 AHSA1 GRB2 MAP2K3 TRAF2 CREB1 PMC11755879__F3 NLRC5 in cancer LMX1A VEGFA CTNNB1 PMC3944192__F1 Kidney Regeneration: Common Themes From the Embryo to the Adult SALL1 LHX1 PAX2 BMP4 BMP2 PAX8 BMP7 WNT9B WNT4 WNT7B PMC9614744__F7 Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D EGF JUN BAD CBL BTC GRB2 SHE MYC PMC9614744__F8 Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D MAX ECSIT GAL FAS APMAP CD14 ASIC2 MIF TRAF6 DAO NLK GRB2 TRAF2 PMC6314413__F3 Representative Wzx/Wzy-dependent capsular polysaccharide (CPS) biosynthesis pathway in the group B streptococcal serotype III GAL SCOC ACCS PMC6916502__F7 Proposed mechanisms for panx1 regulating ferroptosis in renal IR injury PANX1 FTH1 PMC9136161__F2 Degradative and Non-Degradative Roles of Autophagy Proteins in Metabolism and Metabolic Diseases SNAP23 SEC22B SNAP29 STX4A STX3A PMC11625861__F1 The HS biosynthetic pathway GLCE B3GALT6 EXT2 XYLT1 EXT1 HS2ST1 PMC11765393__F1 Insulin signaling pathway in a healthy human brain GRB2 MTOR SHE NRF1 IRS1 PMC9084498__F1 Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity HEL-S-5 CS PMC4807882__F3 A Review of Systemic Treatment in Metastatic Triple-Negative Breast Cancer NR1i1 EGF CXCR1 CTLA4 GRB2 MTOR SRC PMC9181737__F2 Molecular Insight into the Therapeutic Effects of Stem Cell-Derived Exosomes in Respiratory Diseases and the Potential for Pulmonary Delivery TLR4 IKBKB PMC9019758__F9 Bushen Culuan Decoction Ameliorates Premature Ovarian Insufficiency by Acting on the Nrf2/ARE Signaling Pathway to Alleviate Oxidative Stress BACH1 CLU MAL MAF PMC7969947__F3 Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition ALK TFG MTOR PMC8864737__F3 WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization TH PMC4280296__F1 Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement MTR PMC6014344__F4 Cross-link between TGFB pathway, Wnt pathway, and ILK pathway TGFB1 SMAD2 APC SMAD4 PMC7976506__AF1 Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease CIT PMC6014344__F2 Molecular mechanisms involved in induction and progression of podocyte EMT caused by hyperglycemia CAD HEL-S-28 CTNNB1 PMC6014344__F3 TGFB/Smad classic pathway SMAD2 SMAD4 SMURF2 SKI PMC8864737__F2 WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization ART1 PDHA1 HEL-S-68p FBP1 AIP FAT1 AMH PCK1 HEL-S-26 FAT3 PMC8107416__F1 DHODH and cancer: promising prospects to be explored CAD OMP UMPS DHODH PMC7969441__F3 Telomere signaling pathway linking DNA damage response (DDR) and activation of ATM/ATR kinase, cycle arrest, and initiation of DNA damage ATR ATM POT1 PMC4705829__F1 Signaling crosstalk between the mTOR complexes MAF1 EIF4B TTI1 POLI MTOR DEPTOR RAC1 IRS1 EIF4E RHEB MLST8 TSC2 EEF2K RICTOR TSC1 TBC1D7 ELF3 PMC3827841__F6 TGFB and NOTCH activation in AoSMCs stimulated with P SMAD2 SMAD4 HES1 PMC9569545__F1 Mitochondrial DNA Repair in Neurodegenerative Diseases and Ageing MFN1 MFN2 SSB PMC3827841__F3 Protein-protein interaction network and SPIA analysis of the 28 up-regulated genes related to positive regulation of cell proliferation and 21 down- regulated genes related to negative control of cell proliferation KLF4 TBX2 TGFB1 HEY2 SPHK1 PML TGFBR1 TNFRSF8 PRKCA SOX4 ADM CTTNBP2 IL34 PDGFA NGFR TGFBR3 IGF2 TNLG2B ATF3 EFNB1 HBEGF COL18A1 SCG2 BMP2 FGFR3 BDNF BDKRB2 ADA PMC8365418__F10 Study of the pathology and the underlying molecular mechanism of tissue injury around hematoma following intracerebral hemorrhage NEUROD1 ASCL1 NGFR DLX5 NEUROD6 RET PMC7298859__F7 TNFA/TNFR2 immune checkpoint signaling pathway could be used to target different aspects of tumor cells micro environment CD80 TNF PMC1235815__F7 Possible ATM pathways contributing to polyomavirus replication (see Discussion) BRCA1 C2 CDK2 ATM MDM2 PMC3796519__F6 IL-27 Enhances the Expression of TRAIL and TLR3 in Human Melanomas and Inhibits Their Tumor Growth in Cooperation with a TLR3 Agonist Poly(I:C) Partly in a TRAIL-Dependent Manner STAT3 STAT1 TLR3 PMC3879613__F7 Biological functions regulated by miR-378 and miR-378* HEL-S-133P HEL-S-69p PMC9292677__F1 Uncovering the ‘sphinx’ of sphingosine 1‐phosphate signalling: from cellular events to organ morphogenesis SPHK2 SPHK1 LPP PMC9292677__F2 Uncovering the ‘sphinx’ of sphingosine 1‐phosphate signalling: from cellular events to organ morphogenesis PHB2 LMO2 TRIO HGF SPHK1 TRAF2 PMC9292677__F4 Uncovering the ‘sphinx’ of sphingosine 1‐phosphate signalling: from cellular events to organ morphogenesis S1PR1 SPNS2 S1PR3 COX2 S1PR2 SPHK1 GSK3B LRP5 NFATC1 CTNNB1 PMC5167996__F7 A model on how BLM complex promotes FANCM recruitment to stalled forks and replication traverse of ICLs ATR FANCM BLM PMC8201988__F5 Integrative Ranking of Enhancer Networks Facilitates the Discovery of Epigenetic Markers in Cancer BAX EGF IGF1 POLK EGFR MDM2 PROC DAO CDK4 PMC3077922__F3 Gene expression changes in response to zebularine therapy in vivo MGST3 CAST ANXA4 PCGF2 TYMS PHLDA1 MYC NCBP1 TRIP12 MYOC UXT PHB2 SIN3B PTMAP7 LSM1 TMEM126A LSM3 RPN2 HNRNPH1 RPL29 CEPT1 SRPK2 CTNNA1 IMPACT PMC5226641__F1 Dysregulation of MicroRNA Biogenesis Machinery in Cancer RAN DGCR8 XPO5 DROSHA PMC6606799__F2 Temporal changes in the transcriptome related to the central metabolic pathway in a synchronized C MAL FBP1 PMC7461813__F2 TM4SF1 promotes the development and migration of cancer cells CDH2 STAT3 BAX DDR1 PCNA SOX2 DVL2 MTOR VEGFA KRAS CTNNB1 ADAM23 TM4SF1 PMC7409344__F3 eIF4B can stimulate eIF4A EIF4B CTNNB1 EIF4E PMC7312067__F1 MITOL regulates both RIG-I-like receptor (RLR) pathway and Toll-like receptor (TLR) pathway; (B) Relativity between MITOL and cell death signaling in cancer cells MAVS TANK IRAK1 MYD88 PMC7409344__F2 eIF3 consists of the conserved eIF3a, eIF3b, eiF3c and the less conserved eIF3e, eIF3f, eIF3h subunits EIF3S3 EIF3E EIF3F EIF3C EIF3A EIF3B MTOR PMC4320988__F1 Molecular Pathways: Linking Tumor Microenvironment to Epithelial–Mesenchymal Transition in Metastasis CD44 STAT3 LOX SMAD4 DDR2 IL6 ZEB2 JAK1 TWIST1 IL6R PMC6062828__F2 Presynaptic homeostatic functions of calcineurin (CaN) CDK5 HEL-S-11 PMC9356669__F6 Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19 TMPRSS2 MAVS NLRP3 TLR4 IRF9 TLR8 IRF3 IRF7 TLR7 TRAF6 ACE2 PMC8555221__F2 Systematic review of proteomic biomarkers in oral squamous cell cancer CDK6 CCND1 CDK4 PMC8903576__F11 Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism STAT3 BAX ATF4 MTOR EIF2A PMC6260243__F4 JAK1 may be the target molecule of (+)-terrein in the IL-6 signaling pathway in HGFs STAT3 CSF1 GRB2 VEGFA PMC3681875__F7 Novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair BRCA1 CDK2 CDT1 PMC8487948__F1 WNT signaling pathway WLS BCL9 RNF43 PORCN APC LRP5 ZNRF3 LRP6 GPR49 LGR6 PMC6056413__F7 Schematic diagram showing proposed pathway through which cyclic mechanical loading regulates primary cilia expression to control tendon matrix turnover SET HDAC6 PMC5290160__F7 MYC-mediated mRNA cap methylation of Wnt/Beta-catenin signaling pathway transcripts TRRAP MAX CDK7 GSK3B POLI RNMT MYC PMC10850749__S1 Garcinone C attenuates RANKL-induced osteoclast differentiation and oxidative stress by activating Nrf2/HO-1 and inhibiting the NF-kB signaling pathway CTSK NFATC1 MMP9 PMC8487948__F4 Targeting the WNT pathway- inhibitors in clinical trial WLS BCL9 RNF43 PORCN TNKS APC LRP5 ZNRF3 LRP6 GPR49 CTNNB1 LGR6 PMC8870278__F3 Mitophagy in Viral Infection MAVS NLRP3 TUFM ATG5 PMC5343325__F5 Jak-STAT signaling pathway CBL PIM1 EPO IL6 PMC5343325__F3 P53 signaling pathway TSC2 ATR BAD CYRIA CASP3 CDK2 ATM PTEN MYC PMC5343325__F4 TGFB signaling pathway BAMBI LTBP1 IFNG RBX1 SMAD1 THBS1 FST SMAD4 SKP1 NODAL ARHA PMC3362516__F1 Mitochondrial Ca2+ influx and efflux mechanisms MICU1 LETM1 MFN2 MCU PMC5343325__F2 MAPK signaling pathway MAX ECSIT FAS EVL MOS NF1 CD14 NLK BDNF TNF FLNA TRAF2 PMC4590606__F13 Model of T3-induced hepatic mitophagy RPTOR CAMKK2 FOXO1 ULK1 SQSTM1 MTOR NR1A2 PRKAA1 PMC7462335__F5 Exploring New Therapeutic Pathways in Pulmonary Hypertension. Metabolism, Proliferation, and Personalized Medicine STAT3 BAX EGF TGFB1 EGFR GSK3B HEL-S-28 PTEN HIF1A TERT MTOR ARC FGF2 APP CCND1 PMC6620530__F2 Highlights of tumor metabolism ACSS2 HMGCR GLS HK2 HEL-S-162eP DHFR FASN PDC LDLR TYMS MYC PMC7576358__F9 Mechanism of forsythin protecting RPE cells from apoptosis induced by hydrogen peroxide through the Nrf2 signaling pathway BAX KEAP1 NQO1 PMC6279568__F5 Resistance to MET and MET/MAPK/ERK inhibition in DFCI358 HRAS STAT3 EGFR IGF1R SHE KRAS IRS1 PMC7501145__F1 Nutrient Transporters by Metabolic and Environmental Stresses SIM1 SIM2 APC PMC7097199__F2 Signal transduction by SUMO JUN SMO GRB2 PMC4756895__F1 Metabolic pathways – (a) Metabolic pathway of phenylalanine; (b) Pathway of urea cycle NAGS ASL OTC PMC4078227__F2 Hedgehog signal pathway SUFU SHH SMO GLI3 PMC1948012__F10 Action for AICAR in human leukemia ALL cells RHEB TSC2 TSC1 PTEN MTOR PMC9382309__F3 DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression DDX5 MDM2 PMC4370503__F1 Vitamin D Receptor Cdx-2 Polymorphism and Premenopausal Breast Cancer Risk in Southern Pakistani Patients VIT NR1i1 CDX2 RXRA PMC9489161__F2 Immunological and toxicological risk assessment of e-cigarettes IL6 IL1B PMC7645269__F8 Fibrogenesis during skeletal muscle atrophy TRAF4 SMAD2 NOX4 PMC3323758__F4 DNA base excision repair: A mechanism of trinucleotide repeat expansion OGG1 FEN1 TNR PMC8534645__F2 Sirtuins as Interesting Players in the Course of HIV Infection and Comorbidities SIRT3 NR1C1 FOXO1 FASN SIRT1 SIRT6 PMC9101148__F2 Bioactive Compounds in Obesity: Metabolic Mechanism Focused on Inflammation STAT3 POMC PTPN1 AgRP PMC4353731__F1 Treatment of heterotopic ossification through remote ATP hydrolysis BMPR2 SMAD1 TGFB1 TIMP1 MMP12 ID2 BMP7 RUNX2 COL3A1 SOSTDC1 ACVR1 MSX1 BMP4 ID4 GREM1 BMP2 CREBBP ACVRL1 DLX5 CXCR4 PMC4065826__F2 MAP kinase signaling in SC plasticity NRG1 JUN GDNF LIF CCL2 UNK PMC6146372__F3 Autophagic control of Toxoplasma gondii CD40 IFNG ULK1 EGFR TRAF6 PMC4858865__F1 Overexpressed metabolic pathways in the infection ARG1 AIDA PMC9069556__F2 Coronavirus Infection and Cholesterol Metabolism TG EBP DHCR24 CH25H DHCR7 ACE2 PMC8305159__F5 Antimelanogenesis Effects of Theasinensin A MC1R TYRP1 PMC11117611__F5 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases LATS1 SPRY2 STAT3 NEDD4 PTEN MTOR PMC11117611__F6 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases NEDD4 TXNIP ANXA2 FBP1 PTEN IGF1R PMC9382309__F4 DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression DDX5 APC RELA TCF4 CTNNB1 PMC3372922__F2 Action of TIEG in the TGFBeta-Smad signaling pathway SMAD2 SMAD4 PMC11117611__F3 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases NEDD4 IGF1 PTEN IGF1R RDX PMC11117611__F4 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases NEDD4 YY1 MYC PMC9382309__F6 DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression DGCR8 DROSHA PMC7952134__F4 Bioinformatic pathway analysis of proteins with altered phosphorylation site occupancy in PPP2R5D E420K-variant cells.A, proteins associated with enriched KEGG pathways identified in F ABI2 RBMX ATR RBM22 VASP SHC1 PML WIPF1 MPDZ PTEN MTOR NCK2 SKP2 APC2 MYLK TPR CDK7 ASAP2 AMOT DHX16 WEE1 SI CHUK ZEB2 NCBP2 CDC2 JUN ROCK2 UVRAG MYH1 APC LPAR1 ARHA DEPTOR CRK TSC2 PRKDC ARAP1 SSH1 NUP93 RRAS EP300 SCRIB SNX2 WASF2 MCM2 RNPS1 PMC7952134__F7 PPP2R5D E420K-variant signaling RPS6 TSC2 GSK3A IGF1 GSK3B IGF1R PPP2R5D CTNNB1 PMC7227035__F6 EGFR (a) and NFKB (b) pathway-focused RT-PCR gene expression analysis of representative TNBC PDX RNA samples collected before and after Pan-HER treatment STAT3 EGF JUN RELB MTOR PMC12081406__F1 Biosynthetic pathway of sphingosine 1-phosphate and related molecules CERK SMS SPHK2 tmp_locus_29 SPHK1 PMC11211685__F5 Fusarium mycotoxins: The major food contaminants PTEN TNF PMC11211685__F4 Fusarium mycotoxins: The major food contaminants TRO ZEB2 PMC5961061__F1 Structures, enzymes, and reaction mechanisms of lipoic acid metabolism LIPA LIPT2 LIAS SI PMC4816652__F8 Long-term ERK Inhibition in KRAS-mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression SMAD1 ACVR2A CERK DKFZp781O1323 BCR MAPKBP1 HEL-S-28 MAP2 MAPK8 MINK1 PRKCH PMC8884272__F1 Intriguing Role of TLR Accessory Molecules in Cardiovascular Health and Disease TBK1 TRIL CD36 TAB3 VTN IRAK1 IRF3 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR4 LBP HTT PMC8356007__F10 Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research IFNG EGF JUN NR1C1 INSR EGFR FASN IL18 CSK BCL2 PTGS2 MTOR PMC3575666__F4 VPS4B downregulation increases the expression of mitochondrial fatty acid Beta-oxidation related proteins and down regulates the expression of glycolysis related proteins in SKBR3 cells ACLY FH HEL-S-133P IDH3B HK2 FASN LDHB CS ACADM PDHX HADHB SUCLA2 HEL-S-68p HEL-S-162eP ENO1 MDH2 HEL-S-87p PMC8356007__F11 Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research STAT3 GAL TFRC HEL-S-133P HEL-S-162eP MTOR HEL-S-87p VHL PMC6113216__F7 RGMa regulation of TGFB1/Smad2/3 signaling in astrocytes GFAP TGFB1 SMAD2 SMAD4 RGMA PMC8694403__F3 iTRAQ and PRM-Based Proteomic Analysis Provides New Insights into Mechanisms of Response to Triple Therapy in Patients with Rheumatoid Arthritis TF STAT3 SLC3A2 GPX4 LPCAT3 FACL4 EPO CYC1 PRNP VHL TFRC STEAP3 TLR4 GC HEL-S-87p ATG5 HEL-S-64p CP ADA PMC9246651__F1 Cellular communication network factor 1 by Ras homolog family member A in bovine steroidogenic luteal cells LATS1 LATS2 CYR61 ARHA LHCGR PMC10040775__F5 Low-protein maternal diet during gestation affects the expression of key pancreatic Beta-cell genes and the methylation status of the regulatory region of the MafA gene in the offspring of Wistar rats PPARG ATF3 JUN EP300 INS FGF2 PMC3708799__F2 PTEN in Beta-Cell Growth TSC2 BAD FAS TSC1 GSK3B PTEN MDM2 MTOR PMC8349889__F7 Gene regulation by EGR1 in ABC DLBCL BRD4 SYK STAT1 BTK EGR1 BCR NAB2 IRF7 JAK1 MYC TYK2 PMC7110906__F1 PI3K/AKT/mTOR signalling pathway BAD PTEN MDM2 MTOR DEPTOR ELF3 PMC8577020__F1 P53 family member p73 in the regulation of cell stress response BAX ATR RAD51 BRCA2 COX4I1 ATM CCNB1 GADD45A YAP1 PMC8326120__F1 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue HDAC3 TG CGAS QK3 APPL1 UCP1 XBP1 SIRT1 PMC9428205__F7 Potential regulatory mechanism of inhibiting autophagy to enhance the cytotoxicity of FIIN-2 on A549 and A549/DDP cells BAX FRS2 MTOR PMC8326120__F2 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue TG GC UCP1 PMC8326120__F3 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue TG BMP8B PRDM16 UCP1 PMC8756491__F1 Biallelic variants in MESD, which encodes a WNT-signaling-related protein, in four new families with recessively inherited osteogenesis imperfecta SOST MESD DKK1 APC LRP5 LDLR WNT1 LRP6 WNT3 PMC8326120__F4 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue RHEB TH MLST8 TG TSC2 RICTOR TSC1 GSK3B UCP1 PTEN MTOR DEPTOR PMC8326120__F5 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue TG TSC2 TSC1 TRPV3 TRPV2 PRDM16 GC TRPV1 UCP1 PMC5241026__F8 RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms RHPN2 RAB3D ARHA SIRT1 PMC8577020__F5 P53 family member p73 in the regulation of cell stress response PHGDH PSAT1 PFKL GLS2 PMC8714953__F1 Porcine Reproductive and Respiratory Syndrome Virus Evades Antiviral Innate Immunity via MicroRNAs Regulation MAVS STAT2 IRF9 IRF3 IRAK2 IRF7 SOCS3 TRAF6 IRAK4 MYD88 TLR3 IFNAR2 TRAK2 TLR7 TYK2 PMC5597737__F1 Activation of NFKB and IL6/STAT3 signalling pathways in NPC cells by multiple EBV-encoded latent gene products STAT3 TLR3 RELB IRF3 IL6 TRAF3 TRAF6 CYLD TRAF2 IL6R PMC5149556__F1 Molecular events that connect inflammation to insulin resistance in obesity TBK1 TRADD IL16 TLR4 IRF3 TRAF3 TNF TRAF2 MYD88 PMC6366304__F2 Common nodes of resistance to targeted therapies within the PI3K pathway PIK3CA INPP4B EGFR PIK3R2 BRAF PTEN PMC6638189__F1 Overview of RNAi pathways in aedine mosquitoes AGO1 AGO2 DROSHA PMC6366304__F3 Targeting the PI3K pathway in cancer with small-molecule inhibitors INSR IRS1 PMC5453110__F1 IL-8/IL-8R axis SYK CXCR1 PTEN ATF2 IL8RB SRC CTNNB1 PMC4951400__F4 Classification of Colon Cancer Patients Based on the Methylation Patterns of Promoters CCK GDNF BMP3 CRH LRP5 EPO NRG3 FGF5C MTOR FGF8 NRG1 FGF7A DRD2 DRD4 DRD5 SMO WNT3 ADCY1 GRB2 SRC BDNF PMC6906312__F6 Ingenuity Pathway Analysis (IPA) of differential metabolites in POD 7 between GIK and TPN ANGPT4 CP PMC3213398__F7 Working Model for the Late-Acting Function of NFU1 in Mitochondrial Fe-S Protein BiogenesisThe findings of this work suggest a late-acting function of NFU1 in the pathway of Fe-S (red and yellow circles) protein maturation NFU1 ISCU NEU1 ISCA1 PMC6993496__F6 Positional relationships of CDKN3-associated genes in the cell cycle DBF4 PCNA CDC6 SMAD2 SMAD4 MYT1 ORC3 SKP2 ORC2 CDK7 E2F4 CDK2 MDM2 PMC8810313__F1 Viral deubiquitinases and innate antiviral immune response in livestock and poultry TBK1 CGAS MAVS IRF3 IRF7 TRAF3 ISG15 PLP2 TRAF6 PMC6675602__F7 Pterostilbene (PTS) prevented ROS formation and reversed palmitic acid (PA) mediated increase in hepatic glucose production by reducing expression of genes coding for gluconeogenic enzymes and their transcription factors NR1C1 PC PMC6604150__F3 Differentially expressed genes were labeled in the proteoglycans in cancer pathway in the placenta after IVF-ET during the first trimester by KEGG MAFK TIMP3 FRS2 PARL EGFR SMO HEL-S-11 RHO PMC3315368__F4 Gene Array Data from CWR22RV1 xenografts treated with PD325901 for three weeks EGF NGF RALB MOS NF1 EGFR GRB2 BDNF PMC9497767__F4 Epithelial–Mesenchymal Transition by Synergy between Transforming Growth FactorB and Growth Factors in Cancer Progression CD44 FGF7A ESRP2 ESRP1 ZEB2 FGF2 PMC8904967__F2 Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer GPX4 SLC7A11 HEL-S-64p PMC3835685__F1 Human epidermal growth fa ctor receptor 2 (HER2) signal transduction pathways NRG2 EGF NRG1 HBEGF TGFA BTC NRG3 PTEN MTOR UNK NRG4 PMC11542427__F3 Shows that, owing to aging, there is an increased release of proinflammatory adipokines that stimulate the activation of TNF, TGFBR, and insulin receptors FOXO1 EBP ULK1 APC UCP1 KLF5 CTNNB1 PMC4657121__F1 Amino acid metabolic pathways targeted in cancer therapy TPH1 ASS1 ASL PHGDH SHMT1 BCAT1 GLS2 PMC6812767__F8 Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions TIRAP TICAM2 TLR9 CD14 TLR5 TRAF6 MYD88 NR1C1 MAP3K7IP1 TLR3 TICAM1 TLR4 TLR8 TLR7 TLR10 PMC6397079__F7 The effect of miR-15a-5p on MK GPVI signaling CRP MYLK SYK FYN PLCG2 PMC8542908__F3 Telomere Signaling and Maintenance Pathways in Spermatozoa of Infertile Men Treated With Antioxidants: An in silico Approach Using Bioinformatic Analysis RB1 TPM1 CCNE1 EGFR MYC MAPK3 PMC7646179__F1 FGF/FGFR signaling pathway CRK FRS2 APP GRB2 MTOR DOCK1 CP PMC11275499__F1 Antidepressant potential of ghrelin, which exerts neuroprotective effects by promoting neuronal proliferation and neurotrophic factor production in the brain STAT3 MTOR BDNF CTNNB1 PMC5852553__F10 Actin cytoskeleton signaling pathway in Cobb chickens OGA ABI2 EGF TRIO PXN APC GNG12 ARHA FLNA DOCK1 HEL114 CRK GRB2 BAIAP2 LBP LCK PMC4599016__F5 Two separate GA13 Switch Region signaling pathways TPR SRI ARHA PMC4442437__F10 Schematic of proposed mechanism for CpG-induced enhancement of the transepithelial transport of H9N2 WIV in nasal mucosa CD40 CD80 TLR9 CCL20 PMC2912657__F1 NFKB activation pathways CCL19 ARHA REL PMC8593035__F7 Mechanism of NUSAP1 promoting DNA repair process by binding with RAD51 RAD51 NUSAP1 BRCA2 ATM MDM2 PMC11917137__F7 Schematic model for the mechanism and role of HOGA1 in ccRCC HOGA1 CCND1 CTNNB1 PMC3670289__F3 Differential STAT3 signaling in the heart STAT3 PDPK1 GSK3B JAK1 PMC8582810__F7 Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer BAX MEI1 DIABLO PMC6456510__F5 Possible regulatory association of miRNA let-7-related gene networks HIF1AN ADRB2 PMC4605443__F2 The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective TEC TREM2 SYK DOK3 GRB2 MYD88 PMC4520659__F4 Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARA expression FABP5 RARB CRABP2 CRABP1 PMC7545926__F8 Schematical representation of the protective mechanism of H2O2 preconditioning for improving the therapeutic potential of BMSCs GSK3B MTOR CXCR4 CCND1 PMC4605443__F1 The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective TEC TREM2 SYK SOS1 GSK3B GRB2 SRC CARD9 CTNNB1 PMC5036923__F1 The IMD pathway and its regulation by Die and WntD FZD4 FADD PMC6366304__F1 Common PI3K pathway aberrations found in a variety of solid tumor types PIK3CA INPP4B PIK3R1 PTEN FGFR2 PMC8995746__F1 Targeting NLRP3 Inflammasome With Nrf2 Inducers in Central Nervous System Disorders NLRP3 KEAP1 COX2 TXNIP MAF PMC8323235__F9 ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways FOXO1 EGFR GSK3B IRS1 PMC6001480__F3 Functional networks in mucinous type epithelial ovarian cancer MED23 EIF4G1 ELAVL1 PSMB8 PSMB10 SNW1 PSMB2 KAZN CACYBP NR1A2 PPL RPAP3 PMC9476644__F3 Curcumin's prevention of inflammation-driven early gastric cancer and its molecular mechanism BAX WNT3A APC GSK3B LRP6 MYC CTNNB1 PMC5115347__F1 The degranulatory signaling cascade of RBL‐2H3 (adapted from refs SYK LAT LYN PMC7539839__F1 Mitochondrial roles in health and disease PINK1 OPA1 MFN1 MFN2 FES PMC8324678__F3 Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD PNPLA3 TM6SF2 MBOAT7 ADFP PMC5294487__F1 Steroid hormone synthesis and endogenous oestrogen metabolism in humans CYP17A1 CYP11A1 CYP1A1 CYP3A4 PMC3350790__F1 Dmrt genes integrate sex-specific, spatial, and temporal cues to induce sexually dimorphic differentiation in restricted groups of cells VAV1 RHO PMC4589549__F4 Canonical Wnt pathway illustrating the roles of PITX2 dependant genes NKD1 CD44 DKK4 APC LRP6 MYC CCND1 PITX2 CTNNB1 PMC2633299__F11 UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes COX1 PLCB1 TEP1 PMC3081620__F1 Representative cascade of the TGFB pathway TF SMAD2 SMAD4 PMC5645534__F2 Overall survival mechanism used by the Apicomplexan parasites in different host cells SOCS1 STAT3 BAX IL10 BAD HGF EGFR PTEN MMP9 MTOR TG BCL2 SRC TRAF2 CP PMC2394768__F4 Network diagram comprising genes and functional processes associated with regulated AS events in the CNS PACSIN2 OPA1 MAPKAPK3 MYO6 GHB2 RHO SYNE1 PMC6269430__F5 General mechanism of Wnt induction BMI1 CDKN2A PRC1 USP16 PMC2757291__F6 The SLAM-Associated Protein (SAP)/Fyn/PKCθ Pathway is Required for Thymocyte-mediated CD4 T Cell Development TEC FYN APC PMC8290884__F2 Selective Neuron Vulnerability in Common and Rare Diseases—Mitochondria in the Focus VPS35 PINK1 MOS OPA1 LRRK2 MFN2 GDAP1 OPTN PMC8910853__F3 Aldehyde Dehydrogenase 2 as a Therapeutic Target in Oxidative Stress-Related Diseases: Post-Translational Modifications Deserve More Attention BAX ALDH2 TGFB1 SIRT1 PMC11765076__F1 Aerobic glycolysis in cancer HEL-S-162eP HEL-S-30 CP PMC8618899__SF1 Time-Dependent Changes in Hepatic Sphingolipid Accumulation and PI3K/Akt/mTOR Signaling Pathway in a Rat Model of NAFLD ASAH2 TSC2 BAD SPTLC2 TSC1 GSK3A SMS SPHK2 tmp_locus_29 GSK3B PTEN MTOR PMC3416606__F1 Central carbon metabolism in S HEL60 tal-1 GPD2 BDH1 ACO2 ENO2 HEL-S-68p HEL-S-32 ENO1 MDH2 HEL-S-26 GPD1 PMC11765076__F2 Pentose phosphate pathway and its connections with our metabolic pathways HEL107 RPE RPIA PMC7491459__F3 Schematic diagram sketching three well-characterized pathways (3 vertical lanes) in which TGFB plays a role via signaling and/or transactivation/crosstalk and which may act to promote or prevent hypertension EMILIN1 HBEGF TGFB1 TGFBRAP1 ADAM17 EGFR SMAD2 PMC4130844__F1 Signal transduction and immune response in Helicobacter pylori infected gastric epithelial cells BAX JUN PAK1 TLR4 NOD1 IL6 GRB2 SRC GPT PMC11765076__F4 Serine metabolism pathway PHGDH DHFR SHMT1 PSAT1 TYMS HEL-S-51e PSPH PMC6695959__F1 DNAM-1 signaling pathway leading to natural killer (NK) cell activation CD96 TIGIT NECTIN2 FYN VAV1 PMC11765076__F5 Proline metabolism pathway PRODH PMC11765076__F6 Tricarboxylic acid (TCA) cycle or Krebs cycle FH ACO2 IDH3B CS SDHD SDHA SDHB SUCLG1 OGDH SUCLG2 DLD MDH2 SDHC PMC5398979__F2 Pathway alterations in glioblastoma EGFR BRAF PTEN CDKN2B RB1 MDM4 CDKN2A CDK6 CDKN2C NF1 PDGFRA MDM2 CDK4 PMC10344634__F10 Graphical abstract COPS6 CDH2 HEL-S-87p PMC8324678__F1 Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD LPA PC ADFP PMC7283464__F2 Enteroviruses regulate apoptosis through the PI3K/AKT pathway BAX BAD MDM2 PMC9107190__F9 Label-free LC–MS/MS proteomics analyses reveal proteomic changes in oxidative stress and the SOD antioxidant strategy in TM cells SELE SMAD4 MMP2 PIN1 TNF DAO PMC9219453__F5 Relationship between Plasma Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Level and Proteome Profile of Cows TF RBP5 ADCYAP1R1 CES2 HEL-S-62p CFD HEL111 CFH RBP4 GNG2 GNAS TFRC RBP2 CFP RBP1 PMC8037268__F17 Signaling pathways affected by hSDC1 overexpression in DEN-induced hepatocarcinogenesis HBEGF AXL INSR EGFR APC SDC1 REL DEPTOR CCND1 CTNNB1 EIF4E PMC7174595__F1 Lysophosphatidic acid (LPA) as a promoter in Alzheimer’s disease (AD) related neurodegeneration LPA BAX CASP9 BAD HEL-S-62p CASP3 ARHA RHO PMC9650365__F1 Crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease BAX ATG3 ATG12 ULK1 MTOR ATG5 PMC7466743__F5 Targeting the CLL/MSC crosstalk using CXCR4/CXCL12 and BCR signaling inhibitors CXCL12 SYK BCR MSC BCL2 LYN CXCR4 PMC3946676__F1 Changing appetites: The adaptive advantages of fuel choice ATR FAS GLS PHGDH HEL-S-26 PMC3946676__F2 Changing appetites: The adaptive advantages of fuel choice MTHFD2 MTHFD1 PHGDH MTHFD1L SHMT1 HEL-S-51e PMC5354934__F3 Anti-tumor activity of metformin: from metabolic and epigenetic perspectives IGF1 MTOR PMC8169546__F1 The Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases STAT3 KEAP1 EGFR PMC6471792__F3 Hypothetical G protein-coupled receptor (GPCR) heterodimeric T1R2/T1R3 taste receptors exist in a multimeric receptor complex with NMBR, IRB, and Neu-1 in naïve IR expressing cells EBP NMBR NEU1 MMP9 IRS1 PMC9392712__F4 Targeting autophagy as a therapeutic strategy against pancreatic cancer RPE GOT2 RPIA GLS HK2 GPT2 MAL HEL-S-32 ME1 CIT PMC7504001__F10 Schematic picture proposing that OXY modulates the IL-1Beta-stimulated inflammatory response IRAK1 TRAF6 IRAK4 PMC3442893__F1 Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment PIK3R4 ATG14 MTOR PRODH PMC9392712__F2 Targeting autophagy as a therapeutic strategy against pancreatic cancer ATG101 ATG3 ATG16L1 ATG12 ULK1 ATG14 ATG5 PMC3680918__F6 Schematic diagram of the PIP signaling pathway in ER-negative breast cancer ITGB1 ERBB2 CREB1 PMC8308509__F3 Hypomethylating Chemotherapeutic Agents as Therapy for Myelodysplastic Syndromes and Prevention of Acute Myeloid Leukemia UBE2V2 HGF SP1 IGF1 PRKDC PMC5076460__F6 Global gene profiling of aging lungs in Atp8b1 mutant mice ARHH MYL3 CREBBP ARHA MB PMC5076460__F4 Global gene profiling of aging lungs in Atp8b1 mutant mice RB1 DNAJC3 PIK3CD F3 CREBBP MB PMC5076460__F5 Global gene profiling of aging lungs in Atp8b1 mutant mice ATP2B2 ATP2B1 MB PMC6823401__F10 Figure shows an MPR route that gets activated by the stimulation of progesterone receptor and has a role in cell proliferation by upregulation of PKA/cAMP by the activation of CREB/CREM/ATF-1 RHEB RPS6 STAT3 SP1 EGFR GRB2 SRC CTNNB1 EIF4E PMC8657738__F4 Skin Aging, Cellular Senescence and Natural Polyphenols ACLY LPA GLS CS ME1 PMC4826959__F1 Schematic representation of polycomb-repressive complex 2 inhibition mechanisms ME3 EZH2 SET PMC7765584__F4 Gene network interaction of cancer stem cell signaling pathway in (A) LNCaP cells and (B) C4-2B cells with and without enzalutamide treatment MAPK11 FZD4 INHBE MAPK12 FZD1 MYC KRAS ID3 PMC5920436__F1 BCR pathway activation SYK CD79A BTK BCR LYN MTOR PMC9557748__F5 Terpenoids and their gene regulatory networks in Opisthopappus taihangensis ‘Taihang Mingzhu’ as detected by transcriptome and metabolome analyses IPP MVD MVK PMC7957739__F1 Dysregulation of signaling pathways by chronic viral hepatitis and epigenetic imprinting impact the secretion of circulating candidate biomarkers to the blood STAT3 AFP DKK1 EGFR MTOR GPC3 PMC6701341__F5 Circadian clock pathway mapped with relative expression levels (T1 vs PRL INA PMC4696776__F2A Insights into acute myeloid leukemia via single cell network profiling PLCG2 PI3 ABCG2 CXCR4 PMC8234087__F2 ChoK-Full of Potential: Choline Kinase in B Cell and T Cell Malignancies PLCD3 CD40 LACC1 TRAF3 FAAH MYC BCR TLR4 PEMT PC LPCAT1 STM7 CHKA PMC6950657__F1 Mechanisms underlying the life-extending and tumor-inhibiting effects of calorie restriction in mammals IGF1 NPY IGF1R MTOR PMC9650365__F2 Crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease LAMP2 SIRT3 GSDMD NLRP3 TXNIP MTOR SIRT1 PMC8190181__F1 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer SOCS1 STAT3 TCF12 SMAD2 IL33 SMAD4 FAP SKI LPA CD44 IGF2R EREG SRC PMC5899973__F3 Bile acid–microbiota cross-talk in gastrointestinal inflammation and carcinogenesis LOX MME TNF PMC5899973__F4 Bile acid–microbiota cross-talk in gastrointestinal inflammation and carcinogenesis IFNG SRC MYC FOS IL1B PMC3653888__F3 Yin Yang 1 and Adipogenic Gene Network Expression in Longissimus Muscle of Beef Cattle in Response to Nutritional Management NR1i1 IFNG PPARG ENG GTF2B STAT5B IGFBP5 YY1 RXRB KAT2B PMC3252343__F4 Expression Signature of IFN/STAT1 Signaling Genes Predicts Poor Survival Outcome in Glioblastoma Multiforme in a Subtype-Specific Manner STAT1 EIF1AD IFIT1 USP18 IFI27 MX1 ISG15 OAS1 PMC3653888__F4 Summary of YY1 gene network expression in steers comparing early weaning (EWS) against normal weaning without creep feeding (NWN) at 240 days on treatment.Notes: Cellular locations depicted are from the Ingenuity Pathway Analysis® knowledge base NR1i1 PPARG STAT5B IGFBP5 POLI YY1 RXRB KAT2B PMC11601888__F4 Function analysis of the high-confidence functional lncRNAs RAN SMAD2 BMP4 SOX2 WAS SMAD4 NODAL SET CTNNB1 FGF2 PMC9069003__F3 Action of Ozone Therapy in Emerging Viral Diseases: Immunomodulatory Effects and Therapeutic Advantages With Reference to SARS-CoV-2 NLRP3 KEAP1 MAF ACE2 IL1B PMC9069003__F4 Action of Ozone Therapy in Emerging Viral Diseases: Immunomodulatory Effects and Therapeutic Advantages With Reference to SARS-CoV-2 NLRP3 KEAP1 HIF1A ACE2 IL1B PMC7450930__F7 Distribution of the target proteins of Xiaochaihu decoction on the predicted pathways (The red nodes are potential target proteins of Xiaochaihu decoction, while the orange nodes are relevant targets in the pathway) STAT3 INSR GSK3B MMP2 CCL2 UNK CTNNB1 PMC8835790__F1 Epigenetics in the Diagnosis and Therapy of Malignant Melanoma AMD1 HEL-S-182mP SMS HEL-S-20 SRM SMOX MTRR ARG1 HEL-S-61p UHRF1 MTR MGMT PMC9213320__F1 Scaffold-dependent function of RIPK1 in experimental non-alcoholic steatohepatitis SHARPIN RIPK3 TRADD MLKL TAB3 CASP3 RIPK1 CYLD TRAF2 FADD PMC5397865__F8 Salt suppresses IFNG inducible chemokines through the IFNGamma-JAK1-STAT1 signaling pathway in proximal tubular cells CXCL9 IFNG CXCR3 STAT1 IFNGR2 IFNGR1 CXCL1 JAK1 CXCL10 PMC11753526__F6 Type I interferons attach to their receptors, causing tyrosine kinase 2 to phosphorylate tyrosine and activate STAT1 and STAT2 STAT2 IRF3 TYK2 PMC12241195__F5 Tackling Wnt signaling by the Wnt inhibitor SM04690 PRG4 DYRK1A FOXO1 APC GSK3B CLK2 ARHA SIRT1 PMC4511561__F5 Integrative Analysis of the Developing Postnatal Mouse Heart Transcriptome DBF4 SMAD2 SMC3 SMAD4 ORC1L MYT1 ORC3 ORC2 CDK6 CDK7 E2F4 CDK2 CDK4 PMC8238877__F1 SARS-CoV-2 signals through TLR2 to activate proinflammatory cytokine expression CXCL10 TNF MYD88 PMC7539765__F5 Probable interactions among TRIP13 and other molecules within clear cell Renal Cell Carcinoma TRIP13 MTOR HES1 PMC8586510__F2 Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh WNT10B SHH KIT WNT3 WNT4 WNT7B PITX2 FGF8 PMC11753526__F2 Comprehensive examination of the Toll-like receptor 9 (TLR9)-mediated signaling pathway TIRAP TAB3 IRAK1 IL6 TRAF6 CCL2 TNF CCL20 IRAK4 MYD88 PMC6351931__F10 Schematic diagram of the signaling pathway relevant to HKMT-induced pleural fibrosis in pleural mesothelial cells (PMCs) TLR4 NOX4 PMC8534156__F3 Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers CSK GRB2 SRC PMC8534156__F5 Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers CBL CRAT SRC PMC4367644__F1 IGF-1R Signaling Pathway BAD IGF1 PTEN IGF1R MTOR PMC4494900__F3 Emerging role of CaMKII in cancer TIAM1 CDK4 PMC6833135__F3 Gene expression levels of central carbon metabolic pathways TH HEL60 ACO2 ENO2 PGM2 HEL-S-49 MAL HEL-S-4 MDH2 HEL-S-26 ADH5 CIT PMC4541321__F2 Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case CSA2 PRODH PMC2448841__F5 Proposed model of arrest of maturation/activation of DCs via ILT4 receptor and HLA-G ligand STAT3 HLA-G TLR4 CSK TRAF6 MYD88 PMC8672651__F1 Complement as driver of and therapeutic target in COVID-19 MASP1 FH MASP2 C1S C1R RELA CD46 ACE2 PMC8570289__F1 Key Activating and Inhibitory Ligands Involved in the Mobilization of Natural Killer Cells for Cancer Immunotherapies ZAP70 CD48 SYK VAV1 MTOR TIGIT HLA-E FYN HLA-B GRB2 HLA-C HLA-A LCK PMC11854242__F5 YAP-mediated gene expression in liver fibrosis LATS1 LPA LATS2 ANKRD1 COL1A1 ROCK2 ARHA SRC PMC11854242__F6 Mechanosignaling via Integrins: Pivotal Players in Liver Fibrosis Progression and Therapy ACTA2 SMAD2 SMAD4 COL3A1 PMC11854242__F4 Rho/ROCK/MRTF/SRF transcription pathway and its upstream regulation by the actin cytoskeleton in liver fibrosis LPA COL1A1 ROCK2 ROCK1 ARHA SRC PMC9037381__F2 Pathogenic Mechanisms of Fusobacterium nucleatum on Oral Epithelial Cells SNAI1 PMC5625807__F2 Genes identified from the enrichment analysis were significantly associated with OSA comorbidities LIPC LEP HTR3D LEPR EDNRA ADRB2 HTR2A PMC8102094__F3 Positive and Negative Regulation of Ferroptosis and Its Role in Maintaining Metabolic and Redox Homeostasis ATM SLC7A11 GLS2 PMC2661962__F1 Where Do MAIT Cells Fit in the Family of Unconventional T Cells? CD27 MR1 ZBTB16 CD1D PMC6003288__F2 Luteolin inhibition of receptor-mediated tumor progression.Notes: Involvement of luteolin (green) in modifying processes necessary for metastasis FOXO3A GSK3B PTEN MTOR CTNNB1 PMC6003288__F3 Luteolin-mediated extrinsic and intrinsic apoptosis in breast cancer.Notes: Illustration abridging the involvement of luteolin (green) in purposed apoptotic pathways BAX FAS FADD PMC9037381__F3 Pathogenic Mechanisms of Fusobacterium nucleatum on Oral Epithelial Cells HMGB1 NLRX1 NLRP3 NLRP10 CD46 IL1A ADAM8 MMP9 CTNNB1 PMC8203678__F5 Genome-wide portrait of pervasive drug contaminants CPA2 CPA1 ARG1 ARG2 PMC7841880__F1 Canonical PTEN pathway depicting PI3K/AKT/mTOR and MAPK/ERK signaling RICTOR PI3 PTEN MTOR EIF2A PMC7333890__F2 Stress responses to aneuploidy and radiation ATR ATM PMC3359076__F5 Regulation of thrombin-induced RelA/p65 nuclear translocation by the Rho-actin pathway CSA2 RELA ARHA PMC4077945__F1 Lipid metabolites as metabolic messengers in inter-organ communication FAS NR1C1 ELOVL6 PMC4979518__F6A mTORC2 controls cancer cell survival by modulating gluconeogenesis PRMT1 STAT3 ENO2 FABP1 MTOR PCK1 CHUK AKT1S1 MAPK1 SGK1 PCK2 RHEB PGAM1 TSC2 RICTOR PGAM2 TSC1 ALDOB ENO3 FBP2 HEL-S-68p HEL-S-162eP RXRA FBP1 CDK2 ENO1 HEL-S-87p PMC3134408__F1 Proposed molecular pathways in arterial, venous and lymphatic specification in a developing embryo EPHB4 PROX1 HEY2 FOXC2 FOXC1 NRP2 SOX18 SOX7 PMC11053014__F1 Model of Hippo sinaling pathway in mammalian cells and the activity of Hippo sinaling pathway controls the dynamic localization of YAP/TAZ between nucleus and cytoplasm LATS1 LATS2 NF2 PMC11053014__F2 Molecular mechanism by which mechanical cues regulate YAP/TAZ LATS1 LATS2 ARHA NF2 PMC6352980__F2 Paths to stemness: building the ultimate antitumour T cell KLF4 STAT3 KLF2 SMAD1 SMAD2 LIF APC GSK3B LRP5 DUSP9 SMAD4 LRP6 MTOR ID1 ID3 CTNNB1 LATS1 TSC2 TCF3 LATS2 IL24 BMP4 PMC6988818__F2 The Renin-Angiotensin System and Vitamin D in Keloid Disorder—A Review NR1i1 SELL PMC4580089__F1 Intracellular trypanosomatid parasites evade the protective role of IFNG signaling by targeting essential components of the JAK-STAT pathway IFNG STAT1 IRF1 PMC5362524__F8 Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NFKB in vitro BAX EGF EGFR PMC8324391__F1 Reactive Oxygen Species as a Link between Antioxidant Pathways and Autophagy KEAP1 FOXO1 TFEB ATG14 ULK2 SIRT1 PMC4951124__F6 CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling CXCL12 EGFR SMAD4 SRC CXCR4 PMC8396202__F2 Cell-Free DNA in Rheumatoid Arthritis TBK1 CGAS IL18 TLR9 AIM2 IRAK1 IRF3 IRF7 TRAF6 IRAK4 MYD88 PMC2723817__F1 Targeting lung inflammation: novel therapies for the treatment of COPD SLPI CXCL1 CCR2 IL8RB CCL2 HDAC2 PMC11913674__F1 mRNA vaccines immunogenicity TBK1 RIGI MAVS TLR3 BCR APC TLR8 RNASEL IRF3 IRF7 TLR7 MYD88 PMC5671742__F2 Anticancer drugs that induce oxidative stress on endothelial cells NRG1 ERBB4 ERBB2 PMC8190181__F2 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer DNMT3B FOXA1 STAT3 SMAD9 CXCL12 SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 NODAL MMP9 GREM2 FAP RHO MMP2 CXCR4 PMC8190181__F3 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer CXCL12 HGF EGFR CXCL5 SMAD2 SPARC PTEN NODAL MTOR IGF2 CD44 BMP2 VCAM1 CXCR4 PMC8190181__F4 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer CDH2 GFER POSTN EGFR FASN ATF2 VCAM1 CXCR4 TWIST1 PMC5723914__F1 FGFR signaling pathway FRS2 GRB2 PMC12026832__F3 Signaling pathways in cardiac fibroblast LATS1 CDC2 ACTA2 LATS2 TBX20 SOX9 PCNA APC TCF21 MTOR TEAD4 CTNNB1 PMC8221395__F4 Use of Iron Oxide Nanoparticles to Reprogram Macrophage Responses and the Immunological Tumor Microenvironment FTL MAF PIR PMC4983539__F1 Innate Immune Evasion Strategies of DNA and RNA viruses TBK1 MAVS TRIM25 IRF3 IRF7 TRAF3 PMC4986693__F6 Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2 and P-ERK CCKBR EGR1 CCND1 PMC4261029__F1 Schematic illustration of the mTOR signaling pathway, including major upstream regulators and downstream substrates for both the mTORC2 and mTORC1 kinase complexes RHEB MLST8 TSC2 RICTOR TSC1 TBC1D7 PTEN MTOR IRS1 PMC11618000__F8 MST2-mediated Hippo signaling pathway involved in T LATS1 TEAD2 TEAD3 TEAD4 PMC8605871__F7 Whole Exome Sequencing Study in a Family with Type 2 Diabetes Mellitus RHEB TSC2 FAS IGF1 INSR CD36 ULK1 F2 CFTR MTOR INS PMC5957449__F3 Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage POR CYP1A2 GSTM4 ABCC1 GSTM1 MAFF GSTM3 NFE2L2 AHR GSTM5 PMC4459531__F1 Serrated Pathway to Colorectal Cancer CDKN2A APC BRAF KRAS PMC3206070__F2 Temporal Order of Genetic and Pathway Alterations in Tumorigenesis PIK3CA EGFR APC SMAD4 PTEN KRAS TGFBR2 EVC2 RB1 CDKN2A TCF7L2 PXDN EPHA3 HEL-S-26 PMC6590809__F1 Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC4115279__F1 Death-Defining Immune Responses After Apoptosis BAX CAD APAF1 FADD PMC2690992__F2 Signaling control of mesenchymal and amoeboid cell phenotypes ARHGAP22 DOCK3 RHO NEDD9 RAC1 PMC4013251__F1 Canonical microRNA (miRNA) biogenesis pathway: miRNAs are initially transcribed as long, variable-length hairpin RNA substrates called primary miRNAs (pri-miRNAs) directly off the DNA template in the nucleus by RNA polymerase II (A) DGCR8 AGO2 DROSHA PMC7982415__F4 NLR-mediated signaling pathway in mammals GSDMD MAP3K7IP1 NLRP3 CASP5 CASP4 IL18 AIM2 IFI16 NOD1 PMC4781997__F3 Apoptosis through death receptors: a signaling pathway in TLE(HS) RB1 CASP8 TNFRSF1A RELA NFKBIA TNFRSF10A TNFRSF6B PMC7982415__F2 TLR-mediated signaling pathway MLKL TAB3 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 NLRP3 TLR4 CASP3 TLR7 FADD PMC7499322__F2 Promotional roles of MSC-derived exosomes in tumors FGF8A MSC PMC7499322__F3 Inhibitory roles of MSC-derived exosomes in tumors MSC PLK1 PMC4892133__F1 Rapid degradation of HIF-1A by the ubiquitin-proteasome pathway, during normoxia CXCL1 EPO MIF PMC4189449__F1 Pathway where human papillomavirus (HPV)16 E5, E6 and E7 oncoproteins regulate cyclooxygenase-2 (COX-2) expression associated with the cervical carcinogenesis HDAC3 JUN EGFR PMC3678733__F3 Visualization of curated components of pathways and inferred interacting proteins and small molecules LATS2 STK24 CDK3 PMC3678733__F1 Human Hippo signaling pathway AMOT DVL2 HEL-S-1 HEL2 PMC7143141__F1 Long-term recreational football training in successful aging TFAM TSC2 ATG12 NAMPT MTOR PMC8226666__F2 Hippo Pathway: A Master Regulatory Network Important in Cancer JCAD MTOR PMC11641450__F2 Modulation of WNT/Beta-catenin signaling pathway by natural compounds in cancers BCL9 DKK1 APC GSK3B LRP5 LRP6 CTNNB1 PMC4741750__F3 Down-regulation of IKKB expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma CD40 CD80 PIK3CA PIK3CD TLR5 CXCL2 MAPK9 TRAF3 CXCL10 TRAF6 IRAK4 MYD88 MAPK14 MAP3K7IP1 MAP2K4 NFKB1 NFKBIA MAP3K7 CCL4 TLR7 PMC8226666__F1 Hippo Pathway: A Master Regulatory Network Important in Cancer RHO SRC PMC8533696__F3 Targeting Notch to Maximize Chemotherapeutic Benefits: Rationale, Advanced Strategies, and Future Perspectives STAT3 MCL1 DLL4 NUMB BCL2 HES1 PMC6046102__F1 TNBC: The current and upcoming therapeutic strategies targeting the mutant proteins or pathways to enable tailored-therapeutics ATR EGFR BRCA2 DUSP4 PTEN MTOR KRAS BRCA1 NF1 INPP4B PI3 ATM CDC25B PMC10540835__F1 Dopaminergic regulation of inflammation and immunity in Parkinson's disease: friend or foe? TH NLRP3 IL1B PMC4661875__F2 Intrinsic and extrinsic apoptotic pathways: The intrinsic, or mitochondrial, pathway is initiated from within the cell in response to DNA damage, loss of cell-survival factors and severe cell stress FAS TRADD DIABLO FADD PMC2887084__F1 New Strategies in Head and Neck Cancer: epidermal growth factor receptor inhibition in head and neck cancer HRAS EGF HBEGF TGFA PTEN GRB2 MTOR SRC CCND1 PMC3837032__F7 Impaired Nrf2 activation and antioxidant gene expression in fetal endothelial cells in GDM KEAP1 GSK3B MAF PMC3203325__F2 XPC: Implications in cancer and oxidative DNA damage ERCC1 DDB2 PCNA POLK POLE XPC PMC3552145__F10 PGN-induced miR-132 and miR-212 in TLR signaling TLR1 TLR4 CD14 IRAK1 TLR5 IRAK2 TRAF6 IRAK4 MYD88 PMC4896389__F4 Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence CXCL9 CXCL11 ASB1 CXCL12 CD80 PIGF HGF CXCL16 VEGFA CXCL10 CXCR4 TGFBR1 PMC3121188__F7 ERK-dependent signalling during conditioning and extinction of fear JUND JDP2 FAP PMC4351152__F1 MTOR pathway is regulated by numerous upstream pathways, typically in response to growth factors (anabolic) or energy/nutrient deficiency (cell static or catabolic) RHEB RICTOR PTEN MTOR PMC7003380__F1 Biology of ICOS in the tumour microenvironment TH ICOS APC CTLA4 FOXP3 PMC7003380__F2 Targeting regulatory and/or effector T cells with ICOS agonistic or antagonistic antibodies ICOS CD80 APC PMC2430694__F2 Inflammatory Pain: The Cellular Basis of Heat Hyperalgesia NGF IGF1 TRPV1 PMC4251421__F2 Simplified diagram of the mammalian target of rapamycin (mTOR) signaling pathway and its relationship with autophagy and apoptosis RHEB TSC2 TSC1 RHO PMC5727303__F2 Inhibitors of Wnt signalling BCL9 TNKS APC LRP5 LRP6 CTNNB1 PMC8134874__F9 Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells LATS1 TAOK1 TAOK2 LATS2 TAOK3 RHO PMC6149873__F1 Inverse relationship between canonical and non-canonical Hedgehog signaling in colon cancer stem cell (CSC) differentiation PTCH1 SMO PMC10706788__F13 Pathway of glutathione metabolism by EHP in the late stages of infection LAP3 PMC10706788__F10 Pathway of purine metabolism by EHP in the early stages of infection ADM HAMP APP OTP PMC10706788__F11 Pathway of glutathione metabolism by EHP in the early stages of infection LAP3 PMC6776186__F6 Graphical abstract of the model of the activation of IL2RG/JAK/STAT following the overexpression of the ITK-SYK fusion gene SYK IL2RG ITK PMC8134874__F3 Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells LATS1 LATS2 PLCG1 PLD2 ARHA ARHGAP29 PMC8155538__F2 Renal Ciliopathies: Sorting Out Therapeutic Approaches for Nephronophthisis NEK8 AQP2 GPR161 SHH CFTR SMO GLI3 PMC5712254__F1 Metabolic Advantages and Vulnerabilities in Brain Metastases RPIA GLS PFKP HK2 PMC6764236__F2 Regulation of neutrophil metabolism FAS HEL-S-5 MTOR PMC6540463__F3 PI3K-AKT signaling pathway which was achieved by DAVID pathway analysis TSC2 BAD BCR HEL-S-69p RBL2 CD19 PTEN MDM2 MTOR RAC1 PMC6540463__F4 Hippo signaling pathway which was achieved by DAVID pathway analysis ID2 AFP PATJ AMOT APC PALS1 AREG MYC PMC8924093__F3 Anti-HER2 therapy in metastatic breast cancer: many choices and future directions CDK6 IGF1 EGFR PTEN MTOR CCND1 CDK4 PMC6011341__F3 The Base Excision Repair Pathway LIG1 FEN1 PCNA POLE PMC4012266__F2 The autophagy process and signaling pathway ATG10 ATG3 ATG12 MTOR ATG5 PMC3432194__F2 Epistasis network for WTCCC GWAS of bipolar disorder CEP290 PSME4 RIOK3 NEIL3 EPB41L3 FHL2 CMPK2 GRIK2 EDIL3 HEL-S-18 SOSTDC1 PLLP TDG TMTC2 STAB2 SELL SYDE2 NGRN LIPN IPMK ARAP2 TMEM200A SORCS2 SLC24A2 BHLHB2 WDR27 SLC24A1 POPDC1 GNA14 OGFRL1 DPP6 CSMD3 ELMO1 SUDS3 DCDC1 TBCK SNX16 ARPP-21 SLC10A2 GPR37 ST6GAL2 SPTLC3 FBXW11 ZIC1 PLAA CTNNA2 ADD1 NAPG POTEA WWOX RREB1 CAV3 KMO RIOK2 IFT140 RAC1 CELF2 MRPS23 LMO4 ARL15 WDFY4 RBM19 SLC24A3 HRH2 FAT3 PMC7875896__F8 Protective mechanism of levo‐tetrahydropalmatine against liver fibrosis TIMP1 SMAD2 MMP2 PMC6588884__F2 MET protein structure (a) and HGF/MET signaling pathway (b) HGF GRB2 PMC8209516__F3 Markers and Reporters to Reveal the Hierarchy in Heterogeneous Cancer Stem Cells SOX2 NOTCH1 CTNNB1 HDAC6 PMC9526459__F2 Revisiting potential value of antitumor drugs in the treatment of COVID-19 BTK TLR3 TLR8 TLR7 PMC9496095__F2 Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis WNK1 WNK4 KLHL3 PMC8745273__F6 Brachygnathia Inferior in Cloned Dogs Is Possibly Correlated with Variants of Wnt Signaling Pathway Initiators PLCB4 FBXW11 PCDH19 PRKCH PMC4252624__F5 Glutathione peroxidase activity pathway which was significantly altered in the liver of female LMB, obtained from GSEA, featuring GO terms MGST3 BAX GPX4 LOC51064 GPX3 IL6 GPX1 GPX2 TXN HEL-S-128m ALOX5 CASP3 GPX7 GSTT1 PMC8662121__F1 Type I interferon in the treatment of COVID‐19 TBK1 MAVS TLR3 TLR4 TLR8 IRF3 IRF7 TLR7 ACE2 MYD88 PMC4252624__F6 Classical Complement Pathway affected in the ovary of female LMB (by gene set enrichment analysis (GSEA)) C6 C7 HEL-S-62p C2 C1S C1R C9 C8A C4B_2 PMC8662121__F2 Type I interferon in the treatment of COVID‐19 STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC7261019__F1 Rerouting of glucose utilization in RA and SLE T cells PDP2 PMC7814730__F4 DILI-related processes inferred from predicted targets and pathway annotations CYP1A2 DYRK2 PLA2G1B FABP4 AKR1B1 CCNB3 ESRRA RPS6KA6 NR1B3 CSNK2A2 CYP2C9 AKR1C2 PRKAB1 PTGES NQO2 PMC6156325__F4 BH4 modulates the nitrosation of key proteins in the Ubiquitin-Proteasome system PSMD11 PSMD2 PSMD6 PMC5524794__F1 Protoporphyrin IX biosynthetic pathway in the shell gland of brown egg laying hens SLC25A38 CPOX ABCB6 ABCG2 FECH UROD UROS PMC2692422__F7 IL-1Beta-induced upregulation of RGS4 expression in colonic SMCs via canonical IKK2/IKBA/NFKB signaling is differentially modulated by the MAPK and PI3K/Akt/GSK3B pathways GSK3B RGS4 IL1B PMC5901847__F1 Diagram of signal pathways and molecules participating in the preservation of the pluripotency state and reprogramming CASP9 EGF BAD SAG SUFU APC LIF SOX2 SMO GRB2 SET CTNNB1 PMC3446495__F1 Impaired immune system in patients with systemic lupus erythematosus (SLE) IL10 TNFAIP3 NCF2 RASGRP3 HLA-DRB1 APC IFIH1 IRF7 IRF8 TNLG2B BLK PTPN22 ITGAM PDC STAT4 LYN UBE2L3 PMC7230071__F1 Key regulators of ferroptosis SLC3A2 PGP KEAP1 GPX4 LPCAT3 BAP1 FACL4 SLC7A11 MDM2 PMC9573482__F7 Quercetin and Resveratrol Differentially Decrease Expression of the High-Affinity IgE Receptor (FcERI) by Human and Mouse Mast Cells SYK LAT LYN GRB2 EIF2A PMC4015830__F2 Intersection of BC modules 143, 79 and 82 ERBB4 RBL2 IL20RA CCNA2 SKP2 EEA1 ERBB3 IL2RB UBTF CDKN1A INSRR CBLC CDK3 KRT27 PMC7140647__F5 Different potential contributing players and their pathways activated in proposed antibody-dependent NK cell-mediated cytotoxicity in the thyroid gland of AITD patients SYK PAK1 TPO MICA MICB HLA-C PMC5657500__F1 Death receptor signaling in the heart: cell survival, apoptosis, and necroptosis BAX CASP9 TRADD MLKL CASP3 TRAF2 FADD PMC8998918__F4 Environmental Phenol and Paraben Exposure Risks and Their Potential Influence on the Gene Expression Involved in the Prognosis of Prostate Cancer TF BAD PLAT PTEN ERG PMC6707065__F1 Normal Adrenal Steroidogenesis Pathway HSD3B2 CYP21A2 STAR CYP17A1 CYP11B2 CYP11A1 HSD11B2 PMC5878942__F3 Physiology and role of irisin in glucose homeostasis FAS PRMT3 COX2 FOXO1 PCK1 PMC4467417__F5 Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/Beta-catenin pathway ITCH WNT3A DVL2 PMC5878942__F2 Physiology and role of irisin in glucose homeostasis TFAM PYGM NR1C1 HK2 PCK1 PMC2474812__F1 Classical and back-door pathways of androgen biosynthesis HSD17B3 UGT2B15 CYP17A1 CYP11A1 HSD17B2 AKR1C2 AKR1C1 CYP7B1 UGT2B17 STS PMC3923149__F2 Co-regulation of hepatic wound healing and regenerative responses via TWEAK- and LTBeta-mediated cellular cross-talk LTB LTBR CCL2 PMC8301972__F2 Functional Implications of the Dynamic Regulation of EpCAM during Epithelial-to-Mesenchymal Transition EPCAM SNAI2 SNAI1 TWIST1 PMC6800286__F7 The pathway leading to IL-1B release from NK92 and its inhibition by DMF or MMF DNMT3B GSDMD IL1B PMC2615236__F1 Regulation of IGF-I Function by Proinflammatory Cytokines: At the Interface of Immunology and Endocrinology TSC2 BAD PI3 AKT3 IGF1R GRB2 MTOR CTNNB1 EIF4E PMC6915875__F6 The mechanism of AML cell-secreted exosomal miR-4532 in hematopoiesis of HSCs LDOC1 STAT3 DKK1 PMC5803787__F7 Model for the fate decision of XY PGCs regulated by stage-specific FGF9 levels STRA8 FGF9 NANOS2 PMC5413166__F5 An example of innate immune response induced by E2 in ML-1 cells SCARB2 SACS MAFF PORCN CXCL16 CYC1 PSG1 PMC4383884__F5 Cisplatin response pathway SLC22A4 SLC47A1 SLC22A2 PMC5250589__F1 Impact of ELS on the normal development of tissues and organs CRP NGF GC BDNF PMC6262822__F1 Parts of the signaling pathways of the five mutated proteins in the 5 syndromes of this review CASR TSHR FSHR PMC3197531__F12 Beta-Adrenergic Receptor-PI3K Signaling Crosstalk in Mouse Heart: Elucidation of Immediate Downstream Signaling Cascades GSK3A GSK3B MTOR PMC3641604__F9 The innate immune antiviral response triggered by IFNB and TNFA in AECs DUOXA2 TBK1 RIGI MAVS IFIT1 IRF3 TRAF3 DUOX2 TRAF6 PMC4940190__F1 Adipose tissue dysfunction and its effects on tumor metabolism HEL-S-133P HK2 HEL-S-162eP MTOR XBP1 PMC3732559__F5 HMGB1 in Cancer: Good, Bad, or Both? HMGB1 ULK1 HEL-S-102 PMC12167820__F2 Transcriptome analysis of S FH HEL-S-162eP PCCB DAP CS PMC2984446__F10 PI 3 Kinase Related Kinases-Independent Proteolysis of BRCA1 Regulates Rad51 Recruitment during Genotoxic Stress in Human Cells BARD1 RAD51 BRCA1 PMC4673337__F1 Innate receptor signaling and stefin B influence NFKB activation and caspase-11 expression in macrophages NLRP3 TIRAP TLR4 IL18 CD14 LBP MYD88 PMC6116003__F2 Pathway for Type I tumor formation ARID1A BRAF ERBB2 PTEN KRAS PMC2843693__F2 Molecular Origins of Cancer TGFBR2 BAX PIK3CA EGFR APC BRAF SMAD4 PTEN KRAS CTNNB1 PMC4850162__F2 Riboclustering-mediated signaling pathways that regulate innate inflammatory modulators, including cytokines/chemokines HEL-S-76p TLR3 TLR4 TLR5 PMC6116003__F6 Wnt Signaling Cascade APC LRP5 LRP6 CTNNB1 PMC2811231__F7 Gene program of neutrophil recruitment and tissue injury based on gene expression and in vitro data TNFAIP6 FCAR PTGER3 CSF2 B4GALT1 PLAUR FUT7 IRAK1 PTGS2 MYD88 LTB4R CD44 IL1R1 ALOX5 FPR1 PTGES PTGIR IL1B PMC3819010__F2 EBPR metabolic map inferred from the Accumulibacter clade IIA genome, adapted from ) ATR ADK PDC MMD PMC4472235__F2 Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s Disease RHEB RPS6 TSC2 EIF4B TSC1 INSR PC HIF1A RHO MTOR ELF3 EIF4E PMC5136518__F1 Alterations in DLPFC layer 3 pyramidal cells in schizophrenia CDC42 HEL-S-47e LIMK2 PAK1 LIMK1 PMC6078908__F6 Conceptual Circuit Model for How External Warming Induces and Links Sleep and Body CoolingSkin warming activates a pathway that runs through the spinal cord and is relayed by glutamatergic neurons in the lateral parabrachial nucleus [, , ] LPO MPO PMC3624298__F1 Downregulation of human NK cell-mediated cytotoxicity pathway genes in response to Gal-9 ICAM2 CD48 KIR3DL1 KIR3DL2 HLA-E ULBP3 ULBP1 MICA HLA-B MICB ULBP2 PMC6822471__F4 Docosahexaenoic acid (DHA) signaling pathway detected by GSEA BAX BCL2L1 BAD PIK3C2B GSK3A CYCS BCL2 BIK PMC4393792__F2 T Cell Metabolic Fitness in Anti-Tumor Immunity IFNG BAX MCL1 AHR HIF1A SIRT1 PMC7311998__F5 Molecular mechanisms of ID1-mediated BMP signaling pathway to control GLP-1 secretion in GLUTag cells BMPR2 SMAD9 SMAD1 DKFZp781O1323 BMP4 ID1 PMC5134126__F1 Osteoclasts arise from hematopoietic monocyte/macrophage precursors upon interaction of RANKL with its receptor RANK SMAD2 SMAD4 NFATC1 TRAF6 FOS PMC4177360__F5 TLR signaling and CXCR4/7 in human liver MDB formation TLR3 TLR4 CXCR4 MYD88 PMC8909056__F1 Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity TH FOXO3A DOHH PMC7531038__F6 Possible intracellular signaling pathways activated in chondrocytes upon treatment with pararama hair extract TGFBI SP1 HEL-S-62p SMAD2 CXCL16 SMAD4 VEGFA IL6 CCL2 CD44 MAP3K7IP1 MAP2K4 TLR4 NFKBIA PMC7230488__F2 MAPK signaling pathway with nodes color-coded based on the z-value obtained from the meta-analysis of the GSE53987, GSE12649 and GSE21138 datasets MAX RASGRF1 DUSP10 CACNG3 JUND FAS CSF1 TGFB1 RAF1 TRADD SOS1 AKT3 BRAF ATF2 MYC TRAF6 MAP3K14 FLNA MEF2C TGFBR1 DUSP3 MAP2K6 MAP2K4 NF1 CHUK HEL-S-11 ATF4 MAP2K3 ECSIT TNFSF6 CD14 TNF FOS ARAF CRK RAPGEF2 MAP3K7IP1 PAK1 NFKB1 HEL-S-102 TAOK3 NLK MAP2K1 MAP2K2 NFATC3 GRB2 TRAF2 PMC5520917__F8 OA-induced growth inhibition of colon cancer via reprogramming fatty acid metabolism under hypoxia APC FASN HIF1A CTNNB1 PMC2634968__F6 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling IRAK1 TIFA AJUBA PMC3724356__F2 Molecular events in cholangiocarcinogenesis EGF EGFR ERBB2 BCL2 MDM2 PMC2634968__F7 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling TLR1 TLR4 TLR9 TLR8 IRAK1 TLR5 TIFA TLR7 TRAF6 TLR10 MYD88 PMC8504951__F7 Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway STAT3 FGFR1 VEGFA SRC FGF2 PMC8062762__F4 Summary diagram showing potential points in endometrial cell signaling pathways which may be influenced by BVDV infection TRIM56 IFIH1 IRF3 IRF7 RSAD2 TRAF3 TRAF6 IFNG STAT1 TLR3 IFNAR2 IFNAR1 TLR8 TLR7 TYK2 PMC3042723__F2 Signaling pathways regulating dendritic spine actin remodeling with the induction of LTP by theta burst stimulation (TBS).Schematic of signaling pathways linking three classes of synaptic to regulation of the actin cytoskeleton CDC42 ARHA SRC PMC3672788__F6 Summary for the effect of calcineurin inhibitor, tacrolimus, on the regulation of RANKL expression through IL-6/sIL-6R/JAK2/STAT3/SOCS3 pathway STAT3 SOCS3 PMC7976506__F5 Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease FPR2 CIT PMC3734934__F6 Disruption of mindin exacerbates cardiac hypertrophy and fibrosis SMAD2 SMAD4 PMC6627624__F5 Scheme to summarize the current understanding of triterpenoid biosynthesis in metazoans IDI1 MVK PMC3263561__F2 Interaction between glia and neurons may lead to neuron damage and death TLR4 CD14 LBP PMC6627624__F7 Scheme of the post squalene pathway for cholesterol biosynthesis BOC SI SMO PMC6635068__F1 Rb pathway loss and assays for their detection TF RB1 CDKN2A CDK6 CCND1 CDK4 PMC2634968__F2 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling IRF3 IRF7 PMC9295467__F2 Generation of Leydig-like cells: approaches, characterization, and challenges HSD17B3 STAR CYP17A1 SCARB1 CYP11A1 LHCGR PMC8868544__F1 AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis KEAP1 AHR PAH PMC3788325__F2 Signaling pathways in RILF FOXM1 GSK3B ARHA CTNNB1 PMC2634968__F5 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling TLR3 VAV1 RAC1 PMC6446225__F1 Proposed overview of the vascular immunopathology of sickle cell disease (SCD) CD36 TFPI TLR4 FPR1 ANXA1 FPR2 PMC7678118__F5 PDGFRA/EGFR signaling activation and effects on RAS/MAPK pathway EGF TGFA SOS1 GRB2 SRC PMC11213636__F7 Combination of Pirfenidone and Andrographolide Ameliorates Hepatic Stellate Cell Activation and Liver Fibrosis by Mediating TGFB/Smad Signaling Pathway SMAD2 SMAD4 PMC7772566__F6 Mapping germ-layer specification preventing genes in hPSCs via genome-scale CRISPR screening ACLY PPARG CYP4A22 PSME4 MSMO1 UQCR10 MRPL12 HSD17B11 COX7C OAZ3 RPL38 RDH11 PPP2R3C NDUFA10 VNN2 HDAC3 PSMD3 CIDEA ACOX3 IDI1 FDPS AASS ARG2 NMNAT3 ACSL5 SP1 PNMT SCD SQLE SOX2 NAMPT BST1 FABP4 MVK HMGCS1 RPS29 ACAT2 UQCRFS1 MVD EP300 PSAT1 DHCR7 PMC10565042__F1 Diverse types and molecular mechanisms of the Wnt signaling pathway CDC42 ROCK2 APC RYK ARHA RAC1 DAAM1 CTNNB1 PMC5538118__F2 Molecular map of pathways that lead ROS to cause OPC dysfunctioning in SZ RHEB TSC2 NR1C1 TSC1 FYN PDGFRA PDGFA MTOR PMC10565042__F2 Involvement of ncRNAs in modulating the Wnt signaling pathway in prostate cancer APC RYK CTNNB1 PMC10502727__F1 Basic research on chordoma EGFR MTOR PMC9126727__F4 Investigating the Molecular Mechanism of Quercetin Protecting against Podocyte Injury to Attenuate Diabetic Nephropathy through Network Pharmacology, MicroarrayData Analysis, and Molecular Docking COL1A1 PTGS2 PMC10565042__F3 Wnt signaling pathway-related ncRNAs in the regulation of invasion and migration in prostate cancer DIXDC1 NKD1 FZD5 NDRG2 TLE3 FZD2 SOX30 APC EZH2 TUG1 RAC1 HMGB3 SFRP1 CTNNB1 CD44 TCF7L2 PMC10565042__F4 Wnt signaling pathway-related ncRNAs in the regulation of EMT, apoptosis, stemness, and CRPC formation in prostate cancer CD44 RAB11A FZD2 APC LEF1 SFRP1 CTNNB1 PMC7789127__F1 Dual-specificity tyrosine-regulated kinase 1B expression and activity DYRK1B RHO MTOR KRAS RLF PMC7655968__F2 Simplified representation of the structured reaction pathway of glycolysis (Maria, ), and of the TRP synthesis (in the yellow area) (Maria et al., ) in E MAL PTS CIT PMC4428446__F2 Scheme of the signal transduction pathways that control C CDC42 CST5 TPK1 PMC9274486__F8 miR-199a-3p/5p regulate tumorgenesis via targeting Rheb in non-small cell lung cancer RHEB MAPK11 EGFR MTOR PMC8091816__F4 Sulforaphane suppresses lipopolysaccharide‐ and Pam3CysSerLys4‐mediated inflammation in chronic obstructive pulmonary disease via toll‐like receptors TIRAP TLR4 IRAK4 MYD88 PMC8174708__F1 Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies ASL CTH MTRR PSPH PMC5596436__F7 Selected microRNA-target (cell cycle pathways) interaction data CDC2 CDK7 PCNA CDC6 SMC3 CDK2 MDM2 MYT1 SAE1 SKP2 PMC7519685__F4 Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? BAX FAS BCL2 TNF PMC1933372__F3 RAN regulation pathway constituents exhibiting abundance changes, with a figure adapted from the GeneGo MetaCore database RANBP2 SUMO1 RCC1 RAN RANBP1 OTP PMC8789115__F5 Graphlet adjacency captures centrality of cancer driver genes in the FSAHF pathway RB1 UBN1 EP400 HMGA2 HMGA1 CABIN1 H1-0 HIRA PMC7795059__F1 Scheme illustrating the diverse autophagic pathways in cancer cells ATG101 ATG10 ATG3 ATG12 ULK1 ULK2 PMC9578877__F12 Ageing-Associated Transcriptomic Alterations in Peri-Implantitis Pathology: A Bioinformatic Study MAX TF GATA2 EGF VEGFC FAS HGF TRADD FGF21 NFKB2 CYCS MTOR INS POR TXN INSR APP FOXP3 FGF23 JUN GZMK AREG VEGFA ALOX5AP KRAS IGF2 FOS CBFB HOXA9 HEL-S-162eP RELA IKBKB PDGFRA ERBB2 MAP3K7 FGFR3 SDHC PMC11762533__F4 Effect of aberrant activation of the HGF/c-MET signaling pathway on PD-L1 expression in various tumors: increased PD-L1 expression in NSCLC by activating the downstream pathway PI3K-AKT-mTOR STAT1 MACC1 HGF CMTM6 STAT4 MTOR PMC7970325__F8 Reconstructed differential DNA repair molecular network for the comparison of Papillary cancer (PC) vs Follicular cancer (FC) MPG NEIL2 PMS2 NEIL3 FAN1 FANCM ATF2 FANCL FANCA FANCB PIDD1 FANCE FANCD2 FANCG SERPINB5 CDK6 CARM1 MUTYH USP1 WEE1 UNG MDM2 POLE PALB2 CREB1 HES1 MBD4 SMUG1 TDG DYRK2 POLL RAD50 SIAH1 RAD51 KAT5 SP1 H2AX IRF9 PERP NBN ARFGEF2 AREG MDC1 UBE2T ZMAT3 LIG1 MRE11A CDKN1A STEAP3 TP63 CDK2 SESN1 SIRT1 RASGRF1 CDC42 BRIP1 PPM1D ATR FDXR CREB3 PCNA EGFR CD82 BRCA2 SFN PTEN CDKN2D BLM GTSE1 WDR48 TLK1 TOP3A HIPK2 CARD16 PRH2 RAD9A CHEK2 ATM ATF4 GPS2 UNK CDK4 BAX HMGB1 DDX5 RMI2 FEN1 NEIL1 DROSHA RPRM CREBBP EP300 TRAF2 RMI1 PMC11762533__F2 Impact of HGF/c-MET Signaling Pathway on Immune-Suppressive Cells and Their Interactions: Immune-suppressive cells primarily include CAFs, TAMs, MDSCs, and Tregs FGF8A CHI3L1 STAT3 HGF FGFR4 MSC ETV4 ETV2 ARG1 PMC7185194__F6 Novel universal mechanism of immunosuppressive A151 ODN RHEB STAT3 RICTOR PDPK1 MYC PMC11762533__F3 Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion STAT3 HGF ARG1 PMC6943888__F1 Regulation of D-secretase in neurodegenerative diseases STAT1 BACE1 SRPK2 APP BDNF SET PMC11762533__F1 Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion STAT3 CRK HGF CTNNB1 PMC7185194__F2 GGIN identified by IPA software STAT3 JUN EGR1 FOXO3A CREBBP IL2 EP300 PMC11274073__F11 Therapeutic Potential of Dalbergia pinnata (Lour.) Prain Essential Oil in Alzheimer’s Disease: EEG Signal Analysis In Vivo, SH-SY5Y Cell Model In Vitro, and Network Pharmacology STAT3 STAT1 STAT4 IL6 TYK2 IL6R PMC9646457__F7 Myeloid checkpoints for cancer immunotherapy LILRB2 APOE LILRB4 ARG1 B2M SRC LILRB1 PMC2801257__F1 Signaling through the Lymphocyte receptor induces a novel regulatory motif for MAP kinase activation SYK BTK BCR CD22 BLNK CD19 PTEN LYN GRB2 PMC9110840__F1 Advances in the Study of the Ubiquitin-Editing Enzyme A20 TRADD TRAF5 ZNF7 TRAF6 TNF TRAF2 IL1B MYD88 PMC5421515__F1 Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis KLF2 TGFB1 NLRP3 IGF1 ATF2 VCAM1 MTOR TNF IL1B PMC6279936__F1 Processes of liver fibrosis progression and regression during human hepatosplenic schistosomiasis TH EGF HMGB1 IL4 PMC5421515__F2 Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis ATG101 RHEB TSC2 TSC1 ULK1 TRPV1 SQSTM1 MTOR ApoL6 PMC5421515__F3 Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis SMAD1 DKFZp781O1323 ULK1 FOXO3A BNIP3 TIGAR MTOR PMC6626370__F2 Convergent inflammatory signaling through NFKB potentiates BRD4-dependent transcription of VI mediators, a result suppressed by apabetalone BRD4 HMGB1 TRADD CCR2 PMC6651063__F6 DE mRNA corresponding genes in the cultivar “Huoche” under heat stress PRR9 FER PRR7 ELF3 CAT56 PMC4429650__F3 Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis CRP TF COX2 IL16 VCAM1 PMC7185565__F2A Emerging Themes in PDZ Domain Signaling SHANK3 TIAM1 PATJ ROR2 LRP5 CASK RHO PICK1 DAAM1 CTNNB1 PMC5739098__F8 Proposed model of changes in epigenetic status before and after establishing hiONs from hiPSCs and epigenetic silencing by hyperglycemia in orexin neurons OGA OGT GNE GC SIRT1 PMC5145083__F9 Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats MGRA ACE2 PMC7807718__F6 Scheme summarizing the inhibition of H2O2-induced oxidant injury by FPNP via the up-regulation of antioxidant enzymes and TGFB/Smad pathway FH SMAD2 PMC9481960__F1 Knowledge-guided deep learning models of drug toxicity improve interpretation HDAC1 EGFR TOX SRC PMC6635557__F3 Schematic model of AngII-induced and mechanical stress-induced signaling pathway in vascular smooth muscle caveolae CAV3 EGFR PMC12182306__F12 Scheme highlighting the main findings of the study FGF21 CX3CL1 AHR PMC2574839__F2 Androgen synthesis pathway and therapeutic targets HSD3B2 SRD5A2 HSD3B1 PMC3726398__F2 Reconstructing the interactions among different modules of the MAPK pathway EGF SHE PMC4104784__F5 RNA-seq upregulation of energy metabolism gene expression ACO2 NDUFV2 CS UQCRC1 PDHA1 SUCLA2 HEL-S-68p HEL-S-49 HEL-S-162eP UQCRC2 HEL-S-32 ENO1 SDHC ADA PMC5144662__F6 T-cell receptor (TCR) signaling pathway GRAP2 CD3D ZAP70 NFATC2 LAT NFKB2 PAK4 MAP3K14 FYN IL2 LAT2 CDK4 JUN CSF2 IL4 NFATC1 CTLA4 ARHA IL5 PTPN6 FOS HRAS ICOS CBL IKBKB GRB2 CD3G CD3E LCK PMC3492937__F5 Stem cell pathways analysis for label-retaining cancer cell (LRCC) KLF4 DVL1 CXCL12 SMAD1 FOXN1 DKFZp781O1323 DTX1 DTX2 GSK3B CTNNB1 RB1 FGF7A MME CCND2 BMP4 FGFR1 WNT1 CSNK2A1 UTF1 GPR49 SOX17 NEUROG2 SOX2 BMP7 BMP1 BMP2 CYP2C8 LEF1 PMC8392691__F2 Renin–Angiotensin System in the Tumor Microenvironment of Glioblastoma ATR MTOR ACE2 AXIN2 CTNNB1 PMC8657427__F2 Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches CD44 STAT3 BAD PMC7338450__F2 GA12/13 signaling in metabolic diseases ROCK2 USP22 ARHA SIRT1 PMC12093937__F4 Drug targeting on skin cancer stem cell niche PAX3 STAT3 APC SHH SMO MTOR SRC CTNNB1 PMC4385444__F1 Disease implications of the Hippo/YAP pathway LATS1 LATS2 TEAD2 TEAD3 AMOT RHO NF2 VGLL4 TEAD4 PMC7338450__F4 GA12/13 signaling in metabolic diseases VIT ATG12 ATG14 HAS2 NOTCH1 PMC8580835__F2 Host cell-intrinsic innate immune recognition of SARS-CoV-2 SOCS1 TBK1 STAT1 MAVS STAT2 RAE1 IRF3 ISG15 NUP98 KPNA1 PMC8560708__F3 Targeting DNA Damage Response Pathway in Ovarian Clear Cell Carcinoma ARID1A AURKA ATR RAD51 ATM PLK1 TOP2A PMC8560708__F1 Targeting DNA Damage Response Pathway in Ovarian Clear Cell Carcinoma ATR RAD51 PCNA ATM XPC PMC10669528__F4 Process of GSDMD in the pathogenesis of systemic onfection TF GSDMD CD14 AIM2 ACE2 PMC4826038__F3 Serpinin/pGlu-serpinin formation, its signaling pathway and PN-1-dependent biogenesis of secretory granules in (neuro)endocrine cells CGA SP1 PMC11956425__F5 CXCR3/PLC/IP3/IP3R signaling pathway stimulated by PT IFNG CXCR3 GLA CFTR PMC4243952__F2 Impact of cellobiose on central carbon metabolism, amino acid biosynthesis and thiamine biosynthesis of Saccharomyces cerevisiae HEL60 ENO2 ACO2 CYC1 ARG1 CDT1 PCK1 GPD1 PDX1 tal-1 GPD2 HEL-S-68p GLG1 HEL-S-49 FBP1 HEL-S-32 NDE1 ENO1 MDH2 HEL-S-26 ARG2 PMC8392407__F1 Unraveling the IGF System Interactome in Sarcomas Exploits Novel Therapeutic Options TF EPHB4 EPHA2 IGF1 IGF1R IGF2 PMC8392407__F2 Unraveling the IGF System Interactome in Sarcomas Exploits Novel Therapeutic Options LATS1 TF LATS2 IGF1 IGF1R IGF2 PMC12093937__F1 Niche for normal and cancer skin stem cells TCF3 FAS PMC12093937__F2 Core signaling pathways in skin stem cell niche LATS1 STAT3 LATS2 APC SHH MTOR SRC CTNNB1 PMC7236211__F1 Pathway engineering strategy for succinate production in S SDHB MAL CIT PMC7443482__F3 Biosynthesis, transport, and roles of the coenzyme thiamine diphosphate in the model plant Arabidopsis PDC NCS1 PMC12093937__F3 Signaling network in skin cancer stem cell niche PAX3 STAT3 APC GSK3B MTOR CTNNB1 LATS1 TCF3 LATS2 PTCH1 SHH SMO SRC TWIST1 PMC6586801__F2 Hypoxia signaling in human diseases and therapeutic targets ADORA2A ADORA2B ADA PMC3193400__F2 Activation of NFKB and regulation of downstream transcriptional antioxidant and pro-oxidant targets MT3 CYP2E1 RELA RELB GPX1 PMC9240796__AF1 Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway BNIP3 HIF1A PMC4742390__F2 BMI1 regulates BCSC BMI1 DKK1 WNT1 PMC4350683__F6 Regulation of sonic hedgehog expression by integrin B1 and epidermal growth factor receptor in intestinal epithelium EGFR BMP4 BMP2 SMO PMC3668831__F1 Iron regulation by hepcidin STAT3 BMP6 SMAD1 SMAD4 HFE HFE2 PMC8657427__F7 Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches GLS CD36 FASN HEL-S-5 CS PMC6410669__F2 Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives BAX FAS CDK6 CDK2 PTEN MTOR CDK4 PMC9437626__F2 Therapeutic targets by traditional Chinese medicine for ischemia-reperfusion injury induced apoptosis on cardiovascular and cerebrovascular diseases BAX TRADD C2 TNF PMC7463953__F2 Putative target gene interaction network graph generated using Ingenuity Pathway Analysis of miR-34 and miR-181 family miRNAs nodes within a simulated cell PNOC ADA PMC7565866__F3 Micronutrients in one-carbon (1C) metabolism and DNA methylation HEL-S-61p PMC7275785__F1 Hyperprogression to a dual immune blockade followed by subsequent response with cabozantinib in metastatic poor-risk clear cell renal cell carcinoma with NOTCH mutation PTEN GRB2 MTOR HES1 RAC1 PMC5746039__F6 Glycolysis and its branching pathways FAS HEL-S-133P HK2 LDHB PMC3831618__F2 Fe(II)-dependent, uridine-5′-monophosphate Alpha-ketoglutarate dioxygenases in the synthesis of 5′-modified nucleosides LIPN HP LIPK PMC11144369__F1 Outlines of the AhR signaling pathway CYP1A2 COX2 NQO1 AIP AHR AHRR CYP1B1 SRC PMC8006404__F7 Proposed mechanism about excessive caffeine intake-disturbed differentiation of myogenic progenitors through retinoic acid (RA) signaling pathway MYF5 MYH7B PAX7 PMC11144369__F2 FICZ-induced, AhR-mediated skin carcinogenesis from UV radiation EGFR AIP AHR CYP1A1 PMC8790316__F3 Central Role of Extracellular Vesicles in the Mechanisms of Thrombosis in COVID-19 Patients With Cancer and Therapeutic Strategies TF VWF TH APC PC IL1A PMC3751776__F2 BTK signaling pathway STAT3 SYK BLNK LYN PMC3745216__F3 TGFB signalling pathway RBX1 BTRC KEAP1 SMAD4 SKP1 PMC10740823__F9 Graphical abstract of the mechanism COL1A2 SMAD2 SMAD4 PMC6233116__F7 Tbx5 is required for a mesoderm–endoderm bidirectional signaling loop for cardiopulmonary development SHH TBX5 WNT2B PMC6897284__F3 Epigenetic regulation of miR-126 by metabolic changes in malignant mesothelioma ACLY IGF1 SIRT1 PARP1 IRS1 PMC9407090__F1 Prefrontal Cortex Response to Prenatal Insult and Postnatal Opioid Exposure F11R CD80 SELL ITGA4 MADCAM1 ITGB8 SELE SELPLG SELP PMC9407090__F2 Prefrontal Cortex Response to Prenatal Insult and Postnatal Opioid Exposure MAPK1 TPR GRIA2 PRKCE PLCB1 GNA11 PLCB2 GNAL ITPR2 MAP2K1 PMC5949883__F2 Network of metabolic pathways that regulate leukemia TSC2 TSC1 PTEN MYC PMC2758708__F2 Diagrammatic representation of non-canonical Wnt signalling in a mammalian cell SFRP5 DVL1 SMURF1 CELSR1 VANGL1 CTHRC1 PTK7 DVL3 DVL2 ARHA SMURF2 SFRP1 PMC7564482__F1 Folate-homocysteine metabolism pathway and possible causes of folate deficiency HEL-S-182mP DHFR MTRR MTR PMC7862610__F6 Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population CRP CS TNF PMC7589139__F5 The proposed molecular mechanism of glucose-6-phosphate dehydrogenase (G6PD) deficiency in human aortic endothelium and monocytes VCAM1 TNF PMC3179812__F6 Stem Cell Marker (Nanog) and Stat-3 Signaling Promote MicroRNA-21 Expression and Chemoresistance in Hyaluronan/CD44-activated Head and Neck Squamous Cell Carcinoma Cells CD44 STAT3 PMC11964643__F2 Effector-mediated inflammation CDC42 NLRC4 STAT3 TRIM56 PAK1 TRAF6 TRIM65 PMC6386537__F3 Immunologic Pathways in Protective versus Maladaptive Host Responses CXCR3 LTA LTBR OSM CCR2 IL3RA FLT3LG CYC1 MYC TRAF6 CCL2 FLNA DAO CXCL3 IL-21 POR INHBB INHBA INHBE CCL21 CCR7 TPO KDR GCK GHR CAP1 CCR1 TNFSF6 TNF FOS LTB CNTFR TSLP CCL25 GRB2 BDNF IL23R EDAR MAX IL19 TRO EGF FAS LEP TAB3 MPL IFNK IL18 IL2 XCL2 AMH GHB2 ECSIT JUN LIF CD14 CXCL2 IF2G CNTF SF1 IL24 MOS PRL BMP2 CCR4 NLK TRAF2 TNLG7C PMC8306345__F6 Anti-Inflammatory Influences of Cystic Fibrosis Transmembrane Conductance Regulator Drugs on Lung Inflammation in Cystic Fibrosis GSDMD NLRP3 TLR4 IL6 CCL2 TNF IL1B MYD88 PMC3815439__F13 MicroRNAs: molecular features and role in cancer BAX SIRT1 DIABLO FADD PMC2679989__F1 Function of Nod-like Receptors in Microbial Recognition and Host Defense JUN C2 TAB3 NOD2 CARD9 PMC8758217__F1 Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients ATF3 RBX1 KEAP1 ATF4 EIF2A PMC2408406__F1 Microvasculature in the pathogenesis of inflammatory bowel disease CD40 TLR4 PC TLR5 PMC8671602__F4 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity DDX19A MAVS NLRP6 NLRP3 DHX15 IRF3 DDX3X IL1B PMC7790571__F3 KEGG pathway: map04064 LTA TRADD TIRAP LAT RELB BLNK LTB NGF TRIM25 BCR COX2 ATM LYN MIP EDAR CYLD PMC8671602__F2 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity DDX5 MAVS HCGV IRF3 TRAF3 TRAF6 SNRNP200 DDX24 DHX29 DHX15 DDX46 DDX56 DDX60L PMC11782130__F7 Location and role of Gtl2-Dio3 target genes in the Wnt and PI3K-Akt signaling pathway LAMA5 SYK SHISA6 EPHA2 PIK3R5 EGFR PIK3R1 VTN EFNA1 PRKCB CTNNB1 FGFR2 MYLK ANGPT1 BCR OSMR DKK2 STM7 GHR EFNA5 SHISA4 NGFR LRP5 TLE4 LRP6 ARHA ANGPT2 RELN AXIN2 IRS1 SPP1 SFRP1 FGF7 SFRP4 IGF1 IFNAR2 COL4A6 PDGFRA PMC8671602__F3 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity DHX30 CGAS DHX36 IFNAR2 IRF9 IFNAR1 DDX41 IRF3 IFI16 TYK2 DDX60L PMC5997150__F2 Requirement of the Arf6-based mesenchymal pathway in both mesenchymal-type and amoeboid-type cancer invasion LPA EGF EPB41L5 HGF ARF6 ARHA RAC1 PMC8671602__F1 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity TBK1 TLR9 IRF3 IRF7 TRAF3 TRAF6 MYD88 DDX24 TLR1 DDX1 TLR3 DHX36 TLR4 TLR8 TLR7 PMC8546001__F4 BMP signaling requirements in mucociliary cell types SMAD1 DKFZp781O1323 SMAD4 PMC8978634__F6 Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome GSDMD NLRP3 IL1B PMC3013041__F5 Relationship between transcription factors and their regulatory factors TF ELF4 JUND JUNB GSK3B PMC9130463__F3 Transient Receptor Potential Vanilloid1 (TRPV1) Channel Opens Sesame of T Cell Responses and T Cell-Mediated Inflammatory Diseases TRPV1 SMAD4 GATA3 PMC5860983__F11 Human binge alcohol intake inhibits TLR4-MyD88 and TLR4-TRIF responses but not TLR3-TRIF pathway: HspA1A and PP1 play selective regulatory roles TLR3 TLR4 IRF3 TNF MYD88 PMC11808218__F11 Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway TFRC GPX4 SLC7A11 BDNF PMC12229020__F1 ECM deposition-induced inflammation and fibrosis CORT JUN LOX NLRP3 SIRT1 PMC6010831__F9 Proposed model of the mechanism that links mitochondrial dysfunction and insulin resistance in non‐alcoholic steatohepatitis TFAM TG INSR MFN2 NRF1 PMC7347220__F5 Lyme disease bacterium, Borrelia burgdorferi, stimulates an inflammatory response in human choroid plexus epithelial cells ADAMTS15 TXNIP RGMA CMPK2 IFI35 SOCS3 CCL2 PISD CXCL3 GBP4 NGF RTP4 SPOCK2 USP18 FGFR4 OASL CCR7 AMPH APOC1 MPZ STAT2 CDH23 APOE IRF7 HSD11B1 G0S2 LGALS9 RSAD2 OAS3 RNF213 CCL13 UNC93B1 CRLF1 THOC6 DACT2 SMOC1 TNFRSF1B HEL-S-62p DDIT4 IFIT1 IGFBP4 SAMD11 PDE4B TRIM21 TLE2 ISG20 HELZ2 IFI44 POLG CEBPD ELANE MX1 ISG15 OAS1 COXFA4L2 OAS2 GBP2 HEL-S-134P CYP26B1 PARP10 HMFT1766 KCNG2 CPZ INMT HEL163 PHYHD1 PF4V1 PLEKHG3 NGFR BATF2 DTX3L AP3B2 CXCL2 SP110 PDGFRL OLFM2 CXCL6 SMTNL2 CLEC3B CHST7 COLEC11 KCNE4 CYP4X1 RAB20 SLC15A3 HES4 CA11 TRIM25 RASL10B IGFBP5 IDO1 PODN HEL-S-75 THEMIS2 ENPP2 TNFSF10 PMC8436873__F1 Impaired macrophages and failure of steroidogenesis and spermatogenesis in rat testes with cytokines deficiency induced by diacerein STAR NLRP3 CYP11A1 MIF CD163 PMC8382889__F1 Stem Cell-Derived Exosomes Potential Therapeutic Roles in Cardiovascular Diseases CD81 HMFT1766 CD24 CD9 EGFR CD63 EDIL3 PMC7408589__F12 Influence of X-rays (7 Gy) on regulation of the p53 pathway (according to the Mus musculus p53 signaling pathway available at https://www.genome.jp/kegg/) in mESCs in presence of LIF (+LIF) and absence of LIF (-LIF) RFWD2 CASP9 TSC2 ATR SIAH1 PERP LIF CASP3 ATM PTEN MDM2 MTOR PMC11037034__F3 Novel milestones for early esophageal carcinoma: From bench to bed TLR4 SMAD2 MYD88 PMC12229020__F2 Impaired ECM degradation in PCOS BAX LOX COX2 GC BCL2 AHR ATF4 PMC12229020__F3 Altered mechanical forces in ECM remodeling FOXO3A GC PTEN PMC5791855__F1 Tuning the depth of quiescence for cancer therapy RB1 CDK6 CCNE1 CDK2 MYC CCND1 CDK4 PMC7322352__F4 MAPK Signaling PathwayGenes in the pathway are colored based on their expression in TN tumors MAX ECSIT FAS RAF1 TRADD NF1 CD14 GRB2 NLK TNF FLNA TRAF2 PMC2214701__F3 Building bone to reverse osteoporosis and repair fractures DKK1 APC GSK3B LRP5 LRP6 SFRP1 CTNNB1 PMC7322352__F5 MAPK Endogenous RNA NetworkThis figure shows the network of interacting protein-coding mRNAs and non-coding microRNAs in the MAPK singling pathway RASGRF1 STAT3 BAD TGFB1 HGF PXN BRAF IRAK1 MYC TGFBR2 STAT1 ANGPT1 NF1 ATF1 DUSP16 SRC HEL-S-28 NFATC1 RAC1 DOCK1 EIF4E CRK IGF1 MOS PDGFRA CACNA2D1 GRB2 PMC4596691__F4 Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNG Regulation PRLR FLT3 CXCR3 LTBR BMPR1A EPO CXCL3 VEGFB XCR1 INHBB INHBA FLT4 EPOR IF2D CCR7 KDR GHR CSF1R BMPR2 ACVR2A RELT TNFSF6 VEGFA TNF LTB CLCF1 CNTFR IL25 CTF1 TSLP CCL19 NOA1 IL8RB CXCR4 THPO EDAR CCL20 TNLG5A CSF2RA EGF CCL22 FAS HGF TGFB1 LEP INHBC CD27 EGFR CXCL1 IL2RG CCR3 GH1 CSF3R MPL PPBP GHB2 CCR10 IFNA1 LEPR NGFR KIT BMP7 CXCL2 IF2G KITLG CNTF IL2RB IL24 PRL BMP2 IFNB1 IL23A TNLG7C PMC9515549__F1 Enabling factor for cancer hallmark acquisition: Small nucleolar RNA host gene 17 STAT3 CDK6 KLF6 LRPPRC CTNNB1 PMC9553755__F6 Exploring Potential Biomarkers, Ferroptosis Mechanisms, and Therapeutic Targets Associated with Cutaneous Squamous Cell Carcinoma via Integrated Transcriptomic Analysis TH AURKA PMC9700862__F8 Overall mechanisms involved in CNNM4 overexpression caused by APAP overdose CNNM4 ATF4 TNF XBP1 PMC5355168__F1 Warburg effect, hexokinase-II, and radioresistance of laryngeal carcinoma SOCS1 STAT3 INPP4B PMC5467070__F1 Lipopolysaccharide induces apoptosis of hepatocytes via the TLR4/PI3K/Akt/GSK-3B pathway BAX TLR4 GSK3B CD14 LBP PMC7410168__F5 Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control SOCS1 CD40 STAT3 CD80 TBK1 CGAS MAVS PLSCR1 IFIT1 IL21R CTSZ IFI44L IFNG USP18 MX1 ISG15 OAS1 STAT2 IRF9 IFITM1 IFNA4 DTX3L IFI16 IRF3 RUNX3 ICOS CXCR5 STAT4 TYK2 BCL6 PMC2721285__F1 RAS/MAP kinase signaling pathway BRAF KIT PMC8894702__F2 miR-1269a and miR-1269b: Emerging Carcinogenic Genes of the miR-1269 Family HOXD10 CASP9 CASP3 RASSF9 PTEN CDC40 SOX4 HTT PMC8618211__F2 Clinical Manifestations, Pathogenesis, Diagnosis and Treatment of Peripheral Neuropathies in Connective Tissue Diseases: More Diverse and Frequent in Different Subtypes than Expected NGF CIC HEL-S-62p C2 CLC C4B_2 TNF PMC6964037__F4 Functional network analysis of I-MDSCs in CRC microenvironment STAT3 SOST INVS STOM APC NOTUM SKP1 RYK ARHA GRB2 NLK WIF1 PMC9308790__F8 Molecular mechanisms underlying TRIM25-regulated DOX-induced cardiotoxicity TRIM25 XBP1 PMC6290882__F1 Hedgehog signaling pathway SUFU PTCH1 SMO PMC5865869__F3 Differentially-expressed gene pathway network generated using CluePedia TLR3 RHO TNF MYD88 PMC6162445__F3 Mechanism of GPCR bias agonism involves insulin receptor activation ATR EBP NMBR MMP9 IRS1 PMC2435603__F8 Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth by Fluvoxamine: Role of Sigma-1 Receptors, IP3 Receptors and Cellular Signaling Pathways CDC42 NGF GRB2 PMC3265821__F1 Change in RAF isoform usage in response to a RAS mutation BRAF GRB2 PMC6121429__F3 Insulin signaling IRS1 PMC2441985__F3 The regulation of the insulin signaling pathway by miRNA cluster mmu–mir-183–96–182 SHC1 GRB2 IRS1 PMC9686289__F8 Exploring the pathogenesis linking traumatic brain injury and epilepsy via bioinformatic analyses GPR137B AGO4 STAT1 GDF11 INPP5D PIK3C2A GYG1 MBD3 HSDL2 PLXNC1 IGSF6 BSDC1 PMC12176804__F5 IL-17 signaling pathway was enriched in the BD vs S100A7 COX2 S100A10 S100A8 CCL7 MMP3 IL6 MMP9 CCL2 S100A9 CCL20 PMC7758031__F1 Regulatory mechanisms of DELLA stability by PTMs RFWD2 RBX1 DDB1 SKP1 PMC5876660__F3 KSHV regulation of the TLR signaling pathway TBK1 TLR4 TLR9 TLR8 TANK IRAK1 IRF3 TLR7 TRAF3 TRAF6 MYD88 PMC9449932__F2 Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2 TH JUN TJP1 MAVS IRF9 IRF7 GJB1 TRAF6 MYD88 RNF2 IRF2 MX2 MX1 ISG15 TYK2 OAS2 TJP3 PMC7790228__F11 TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response RHEB TBK1 MAVS TFG IRF3 TRAF3 CHAD MTOR PMC11984404__F9 Schematic diagram regarding key parts of this study STAT3 CX3CR1 JAK3 LCN2 PMC7843579__F8 Schematic diagram illustrating the global view of transcriptional changes in MPTP/p-induced progressive PD mice model SERPIND1 TH DRD2 ADM C2 EN1 MTOR PMC5474932__F1 Integrated Transcriptomic and Metabolomic Analysis of Five Panax ginseng Cultivars Reveals the Dynamics of Ginsenoside Biosynthesis ARAF IPP MVP IPMK MVK PMC9267017__F1 Novel Drugs with High Efficacy against Tumor Angiogenesis CDC42 FYN RHO CTNNB1 PMC11016256__F1 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis TGFBI HMGA2 SIX1 SMAD2 SMAD4 PMC5440471__F3 Manipulation strategies of neutrophils and the immune system by P IL16 TNF IL1B PMC5808955__F1 Schematic overview of the effects of Saccharomyces boulardii CNCM I-745 on enzymes within the small intestine MGA PTS SI GRB2 DAO PMC9403334__F3 Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint MCU TRPC3 PMC3618249__F2 Single drug simulation result on T2D model HRAS PPARG CBL SHC1 SOS1 INSR PTPN11 GRB2 AgRP GRB14 IRS1 PMC5270220__F1 APP cleavage pathways ADAM9 BACE1 APP BACE2 ADAM10 PMC11016256__F2 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis SMAD2 ITGA6 PTEN PDK2 PMC11016256__F3 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis HMGB1 RELA RELB PMC3618249__F3 combination drug simulation result on T2D model HRAS PPARG SOST INSR PTPN11 GRB2 AgRP GRB14 PMC11016256__F4 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis HMGB1 HMGA2 ITGA6 SMO PTEN PMC5116470__F1 Some of the known pathways linking DDR to autophagy TSC2 ULK1 ATM PTEN MTOR DEPTOR PMC3058407__F1 Antiviral apoptotic pathway is mediated by IRF-3 and Bax BAX TBK1 TLR3 TLR4 NOD2 IRF3 TRAF3 TRAF6 TRAF2 PMC3612776__F1 Pathways affected in monogenic hypertensive disease WNK1 WNK2 NR3C2 KLHL3 DCT PMC8136436__F1 Biogenesis and clearance of H2S and reactive sulfur species ETHE1 SQOR PMC4832112__F1 Necroptotic pathway MAP3K7IP1 TRADD TLR3 MLKL CYLD TRAF2 FADD PMC8745152__F9 Fibroblast Growth Factor 23 Stimulates Cardiac Fibroblast Activity through Phospholipase C-Mediated Calcium Signaling ORAI1 FGFR1 FGF23 PMC9563553__F1 Impact of the Hippo Pathway and Cell Metabolism on Pathological Complete Response in Locally Advanced Her2+ Breast Cancer: The TRISKELE Multicenter Prospective Study LATS1 LATS2 HMGCR ARHA CTNNB1 PMC5903986__F1 Astrocyte glycogen and lactate: new insights into learning and memory mechanisms PSD MTOR SRC BDNF PMC6003946__F12 SLIT2-ROBO1/ROBO2 and the CDC42-RAFs-ERK1/2 MAPK cascade ROBO2 STAR SLIT2 PAK1 CYP11A1 SRGAP1 ROBO1 FSHR GDF9 PMC8914507__F2 Contributions of glycolytic intermediates and glutamine to collagen protein synthesis GLS PHGDH PSAT1 HEL-S-51e PSPH PMC6769855__F1 Simple depiction of signaling pathways for the activation of classical NLRP3 inflammasome (canonical and non-canonical) and alternative inflammasome CASP8 NLRP3 TLR4 RIPK1 IL1B FADD PMC3417373__F4 Signaling cascades that regulate the intrinsic and extrinsic pathways of apoptosis BAX BAD PTEN BNIP3L MIF EGR2 FADD FGFR2 PMC3058986__F8 Possible role of RACK1 in VEGF/Flt1-induced cell migration VEGFB PIGF VEGFA RAC1 PMC8638980__F5 Association of air pollution and homocysteine with global DNA methylation: A population-based study from North India IL6 IL1B PMC9084887__F2 Advances in the Structural and Physiological Functions of SHARPIN CD40 SHARPIN TRAF2 MYD88 PMC6461947__F6 Current understanding of SHON and ERA signalling SP1 SMAD2 SMAD4 PMC5555159__F24 Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products PIGC PIGF PIGH PIGN PIGA PIGL PIGM PMC3734592__F5 Ingenuity analysis of representative accumulated proteins in response to inactivation of CRL/SCF system MAX STAT3 MAFG SMAD4 RB1 HMOX1 CCNE1 WEE1 SP3 ABCC3 SRXN1 MDM2 CDK4 CCND3 SIN3A FASN NRG1 THRSP MAFF CDKN1A FOXO3A CDKN1B GCLC NFE2L2 SUV39H1 PMC9162151__F3 Pathogenesis and treatment of multiple myeloma BAD IGF1 GSK3B MTOR PMC10041518__F1 Biosynthetic pathways for pyrimidine and purine nucleotides, relevant inhibitors and oncogenic regulators ATR CAD DHFR IMPDH1 IMPDH2 DCTD DHODH ADSL PNP CDA UCK1 UCK2 ATM UMPS ADA PMC7915224__F6A Ins and Outs of RAS Effector Complexes ATR FAS E2F2 GSK3B E2F7 MTOR RHO MYC E2F5 ERC1 CDK6 E2F4 E2F3 E2F6 CDK2 ATM UNK CDK4 FADD PMC10041518__F4 Supraphysiological GTP abundance promotes metastasis through the activation of RHO-family GTPases CDC42 IMPDH1 IMPDH2 RHO GMPR PMC10041518__F5 Hyperactive nucleotide synthesis confers resistance to a range of therapeutic interventions CAD GPX4 HIF1A UMPS DHODH PMC10041518__F2 Nucleotides fuel cancer cell growth and proliferation OGT CDA HEL-S-62p DHFR HIF1A ME1 MYC DHODH PMC10041518__F3 Altered nucleoside handling facilitates cancer cell immune evasion PNP IMPDH1 IMPDH2 GMPR ADSL PMC4818674__F1 Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration PTEN ARHA MTOR PMC7223478__F4 Several major mechanisms that have been implicated in vascular aging SEMA3G EDN1 GC ARHA RHO PMC6195654__F11 BMP signaling pathway overlapped with the results of the comparison BAVc vs SMAD1 JUN DKFZp781O1323 BMP3 SMAD6 SMAD4 BMP7 RUNX2 PITX2 BMP8A BMP6 MAP3K7IP1 SOSTDC1 FST NOG BMP4 GREM1 TLX2 CAMK4 BMP5 NKX2-5 PMC2754156__F3 LPS signal transduction via the MyD88-dependent pathway TIRAP CD14 TRAF6 LBP IRAK4 MYD88 PMC2754156__F4 LPS signal transduction via the MyD88-independent pathway CD14 TRAF6 LBP PMC6195654__F10 Hepatic fibrosis/hepatic stellate cell activation canonical pathway CXCL9 BAX EGF CSF1 HGF EGFR SMAD2 SMAD4 IL4 IL10RA IFNG ACTA2 COL1A1 CCL21 RARB MMP2 PMC7563523__F1 Proteins, non-coding RNAs, and signaling pathway regulators involved in the lack of response of colorectal adenocarcinoma to pharmacological treatment ERCC1 BAD MPG HEL-S-21 EGFR TYMS ATP7B CTNNB1 SNAI1 ZEB2 GPR49 CYP1A2 BAX CES2 APC SOX2 SLC19A1 VEGFA KRAS CD47 XPC EIF4E CD44 PIGF ERBB2 CYP3A4 TWIST1 FADD PMC4762141__F5 Different gene expressions in regulation of actin cytoskeleton pathway in AuNR-treated MDA-MB-231 cells ABI2 LIMK2 PXN APC BRAF GNG12 PAK4 ARHA INS HEL114 CRK F2 WAS DIAPH2 CSK MAP2K2 WASF2 BAIAP2 RRAS2 GNA13 PMC7797663__F1 Central pathway of cancer cachexia involving GDF15 and GFRAL with RET proto-oncogene as a coreceptor NTS GDF15 GFRAL RET PMC6089887__F3 Metabolic pathway map in the plasma comparing common bottlenose dolphins (n = 3, blue columns) and beagle dogs (n = 3, red columns) MIA DAP ACD OTP PMC6136406__F8 Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1–nuclear factorKB/p65 pathway in RAW264.7 macrophages and in COPD mice SIRT1 IL1B PMC4762141__F4 Differential gene expression in glycolysis/gluconeogenesis pathway in AuNR-treated MDA-MB-231 cells DLAT HEL-S-162eP PMC7839966__F5 Comprehensive analysis of the lncRNA-associated competing triplets PMC4779258__F6 Ozone-induced lung inflammation and role of IL-6 signaling pathway: ozone-associated lung inflammation is primarily driven by lipid ozonation products (LOP) and generation of free radicals primarily in lung epithelial cells STAT3 IL6 IL6R PMC12207060__F3 Schematic representation illustrates the molecular mechanism regulating MTNR1A, NEAT1 and AANAT gene expression in renal TECs HNRNPL MTNR1A EXOSC10 PER2 PITX1 AANAT PMC6832198__F4 Intracellular molecular alterations and their effects on tumour microenvironment immune activity KIT PTEN MTOR PMC8396295__F7 Gene-Metabolite Network Analysis Revealed Tissue-Specific Accumulation of Therapeutic Metabolites in Mallotus japonicus CAD PMC12207060__F1 Diagrammatic representation of the melatonin synthesis pathway and melatonin receptor-mediated cell signaling MTNR1A AANAT MTNR1B DDC PMC8361364__F1 Interconnections Between Somatic and Ovarian Aging in Murine Models KIT PTEN MTOR PMC8550885__F2 Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan RHEB TSC2 RICTOR TSC1 TNF PMC5716761__F7 DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer DEK TSC1 MTOR PMC8123408__F2 Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis CDH2 TPH1 PMC8550885__F3 Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan CD80 TLR4 APC TLR9 TLR8 TLR7 MTOR PMC7442594__F7 Schematic proposed model of HDAC10 in KRAS-driven lung cancer development CD44 SOX9 HDAC10 PMC5415769__F3 RICTOR is upstream of multiple canonical pathways TCIRG1 C6 BAX ATP6V1A NDUFS5 PSMC1 NDUFA7 ATP6V0D1 UQCRC1 SDHA RICTOR ATP6V1C1 COX7A2 UQCRC2 NDUFB3 COX6B1 PMC5415769__F2 Canonical pathways form groups for each individual protein SOCS1 TCIRG1 PPARG STAT3 PPIB HMGCL HEL-S-21 ATP6V1A ARPC5 DBT PRPF8 NDUFA7 PTPRC MYC MAPK14 IFNG ATP6V1C1 PLCG2 HEL-S-32 OXCT1 ECHS1 GCLM APOE HSD17B10 INPP5D B2M ATP6V0D1 TUBB UQCRC1 SNRNP200 SDHA MYO1E ACTR2 RICTOR CCT7 COX7A2 OGDH HLA-A COX6B1 CDC42 TGFB1 SH3GLB1 ARPC2 ARPC3 PRPF40A RHO MTOR PNP HADHB INSR MYH9 UQCRC2 APP TLN1 NDUFB3 DYNC1H1 HEL-S-165mP PLD4 PRPF3 MYL6 NR3C1 LBR LAMP2 FTH1 IVD NR1C1 FTL FCER1G TFEB HNRNPC PMC2650010__F1 Akt-dependent and independent mechanisms of mTOR regulation in cancer RHEB MLST8 TSC2 RICTOR TSC1 PI3 PTEN MTOR PMC2650010__F2 Akt-dependent and independent mechanisms of mTOR regulation in cancer RHEB MLST8 TSC2 MAP4K3 TSC1 MTOR PMC2650010__F3 Akt-dependent and independent mechanisms of mTOR regulation in cancer RHEB MLST8 TSC2 TSC1 MTOR PMC4680051__F2 Metabolic networks placing mitochondria at the center of anabolic and bioenergetics pathways in cancer cells HEL-S-133P PHGDH PMC5629070__F6 Schematic representation of the proposed IR signal diversification by ligand-induced crosstalk with molecular partners DDR1 IGFBP2 MTOR IGF2 IGFBP6 PMC6115946__F8 miRNA regulatory pathway in the control of the protein synthesis through SIRT1—TSC:mTOR RHEB TSC2 TSC1 IGF1 IGF1R MTOR SIRT1 PMC4503878__F6 Schematic representation of the dual role of 25-HC in the sterol biosynthesis pathway and the IFN--regulated innate immune response using SBGN system (inset shows key) ATF3 HMGCR CH25H PMC9266903__F1 Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment HMOX1 LOX GPX4 FACL4 PMC3738954__F4 Key signaling pathways modulated by WNV infection SOCS1 TBK1 TRADD MAVS TANK CCL5 TRAF3 TRAF6 TRIP6 MAPK6 MYD88 STAT1 NOD2 MX1 ISG15 SRC OAS1 IL1B CASP9 CASP8 STAT2 IRF9 IRF1 IRF3 IRF7 TNF NLRP1 MAP3K7IP1 CASP3 CCL8 CASP10 TRAF2 FADD PMC8740226__F15 Effect of Chinese Herbal Medicine Mixture 919 Syrup on Regulation of the Ghrelin Pathway and Intestinal Microbiota in Rats With Non-alcoholic Fatty Liver Disease GHSR POMC NPY PMC3932252__F2 Autophagy is negatively regulated by the phosphatidylinositol 3-kinase (PI3 K)/Akt signaling pathway, which activates mammalian target of rapamycin (mTOR) in response to growth factors and also phosphorylates Beclin 1 ATG101 ATG10 ATG3 ATG12 ULK1 UVRAG RB1CC1 MTOR ATG5 PMC2822937__F7 Downstream effectors of the ErbB receptor signalling pathway ERBB3 ERBB4 EGFR ERBB2 PTEN GRB2 PMC4306938__F9 Schematic presentation for araguspongine C-induced autophagic death in breast cancer cells EGF HGF MTOR PMC8896306__F4 Circadian rhythms and cancers: the intrinsic links and therapeutic potentials LATS1 LATS2 PMC2754915__F1 Schematic illustration of different pathways of glucose metabolism in cancer cells HEL-S-133P FASN PDC PMC12103767__F6 Proposed hippocampal signaling pathway altered by early amyloidosis PPP3R1 APOE GSK3B PIANP IGFBPL1 NEUROD2 DAB1 CAMKK2 IGF1 LSR CREBBP RCAN1 HIVEP2 PMC9130080__F45 Triclosan-induced neuroinflammation develops caspase-independent and TNFA signaling pathway associated necroptosis in Neuro-2a cells RIPK3 CASP8 TRADD MLKL TRAF2 FADD PMC3829196__F2 The p53-mediated apoptotic signaling pathways BAX ATR FAS PERP ATM APAF1 PMC3565214__F1 Major oncogenic signaling pathway alterations in urothelial carcinoma TSC2 TSC1 FGFR3 PTEN MTOR PMC6031328__F2 Regulatory mechanisms for alternative splicing impact numerous components of the CME DNAJC6 NUMB CLTB SNAP91 SNX9 EPN2 FCHO1 FCHO2 ITSN2 CLTA EPN1 CLTC ITSN1 PMC6086351__F1 Small Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver RB1 EGFR ERBB2 PMC4593342__F1 Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy MSC HOXB4 CTNNB1 PMC9001149__F10 Signaling pathway and molecular mechanisms underlying TLR/zVAD-induced autophagic cell necroptosis TBK1 STAT1 TLR3 TLR4 IRF3 JAK1 TYK2 MYD88 PMC2754915__F3 Signalling events which determine glucose utilization within the cell PTEN TIGAR SCO2 IRS1 PMC3532876__F2 Vicious spirals of repeating self-accelerating oxidative stress and dysregulated redox and information signaling as possible causes of type 2 diabetes PDX1 TXNIP MAFA PRX NOX4 PMC6800950__F4 SREBP pathway mediated NLRP3 inflammasome activation NLRP3 IL16 PMC3618452__F3 Metabolomic Analysis Reveals Metabolic Disturbance in the Cortex and Hippocampus of Subchronic MK-801 Treated Rats FXN MAK GLRA2 CFH CHKA HTT PMC4160369__F2 Molecular Approaches to Thyroid Cancer Diagnosis TSHR BRAF PTEN MTOR PMC6943935__F3 Noncanonical IL-17 signaling TRAF4 LRIG1 SYK CARD14 BCL10 SOS1 EGFR TRAF6 CCL20 PMC3583298__F7 Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation ATM IGF2 PMC5663620__F1 Novel strategies to prevent the development of multidrug resistance (MDR) in cancer BAX FAS ABCB1 PMC10244677__F1 Integrated high-throughput analysis identifies super enhancers in metastatic castration-resistant prostate cancer FKBP5 BRD4 TACC3 NAV1 BCR PMC9158441__F7 Aconiti Lateralis Radix Praeparata as Potential Anticancer Herb: Bioactive Compounds and Molecular Mechanisms HEL-S-133P HK2 MTOR HEL-S-30 PMC4658032__F8 MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NFKB Signaling Pathway Following Negative Regulation MFHAS1 CD14 TNF MYD88 PMC5786286__F5 5-HT2Asignaling pathways BAX BCL2 GRB2 SRC PMC6530392__F1 Sublytic C5b-9 promotes tumor growth and survival by activating several signaling pathways STAT3 BAX GAL BAD FOXO1 JAK1 PMC11804041__F11 SNHG involved in a serious of cellular biological role in EC BCL9 RECK MTOR SOX4 NOTCH1 PMC6533455__F1 Bone development and skeletal homeostasis LRP4 SFRP4 SOST DKK1 LRP5 LRP6 PMC3910515__F7 TGFB signaling at the BBB during acute peripheral inflammatory pain SMAD1 TGFB1 DKFZp781O1323 SMAD2 SMAD4 PMC8215365__F12 Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection JUN NRK TLR3 MAK TLR4 MAL CD14 FOS PMC6697957__F5 Wnt signaling: a promising target for osteoarthritis therapy SMAD1 COL1A2 DKFZp781O1323 SMAD2 APC BMP2 LRP5 LRP6 DKK2 CTNNB1 PMC9322890__F5 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) BAX CASP9 CASP3 MTOR SRC APAF1 PMC7786386__F4 p38-signaling in white adipose tissue browning MAP3K7IP1 GC UCP1 PPARGC1A ATF2 PMC9322890__F6 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) STAT3 BAX CASP9 TRADD KEAP1 IRAK1 MTOR TRAF6 IRAK4 MYD88 BCL10 CASP3 RIPK1 TRAF2 SIRT1 PMC6697957__F3 Wnt signaling: a promising target for osteoarthritis therapy SMAD1 DKFZp781O1323 SOX9 ANXA6 BMP2 LRP5 LRP6 SMO RUNX2 HES1 CTNNB1 PMC6697957__F1 Wnt signaling: a promising target for osteoarthritis therapy ACAN FRZB SOX6 SOST SOX9 APC LRP5 MMP3 RUNX2 COL2A1 CTNNB1 PMC8161352__F5 Endophytes: the novel sources for plant terpenoid biosynthesis RB1 IPP F2 PMC7600458__F8 Signaling pathways underlying the cooperative relationship between stearic acid and TNFA for MIP-1A/CCL3 production XPA TRADD TLR4 IRAK1 IRF3 TRAF6 IRAK4 MYD88 PMC3598692__F8 Toll-like receptor signaling pathway figure supplied by KEGG ] INTU TIRAP CTSK CD14 IL6 TRAF6 TNF FADD PMC3787652__F2 Differentiation and commitment of IL-17-producing T helper (TH)17 cells in the midpoint of other coacting cells in favor of and against the harboring individual TF STAT3 IRF4 RORA GATA3 ICOS STAT1 IL17RA CCR6 CXCR5 AHR CCR4 STAT4 FOXP3 IL23R PMC11022604__F1 Wnt/Beta-Catenin signaling pathway in hepatocellular carcinoma: pathogenic role and therapeutic target APC GSK3B LRP5 LRP6 CTNNB1 PMC9232692__F2 Emerging roles of spliceosome in cancer and immunity SF1 U2AF2 U2AF1 PMC5569703__F1 Rapid Evolution of Primate Type 2 Immune Response Factors Linked to Asthma Susceptibility CD40 EPX CCL11 FCER1G MBP APC CD40LG TNF PMC9322890__F7 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) CASP9 KEAP1 SMAD2 GSK3B CASP3 PMC3243812__F8 Beta2-adrenergic receptor engagement on a B cell that will make IgE uses a unique signaling pathway to increase the level of IgE produced CD40 ADAM10 PMC6253933__F5 Roles of SIRT7 in cancer CDC2 SIRT7 ZER1 SMAD4 PMC7501977__F1 Underlying mechanism of mitophagy in influencing COPD with different phenotypes PINK1 LRRC2 MAVS NLRP3 MLKL OPTN PMC10879685__F2 NSCLC: from tumorigenesis, immune checkpoint misuse to current and future targeted therapy CDC42 STAT3 EGF CD80 EGFR APC IRF1 PTEN VAV1 MTOR MYC GATA3 STAT1 PLCG1 FGFR1 GRB2 LCK PMC9331826__F1 Epithelial–Mesenchymal Transition-Mediated Tumor Therapeutic Resistance DUSP4 ABCB1 CTNNB1 PMC9331826__F3 Epithelial–Mesenchymal Transition-Mediated Tumor Therapeutic Resistance AXL DCLK1 EGFR CTNNB1 PMC11125956__F7 T helper 1 Activation Pathway SOCS1 CXCR3 ICOSLG STAT3 CD80 CCR5 IL27 SOCS3 NFIL3 TBX21 HAVCR2 IFNG STAT1 KLRC1 MAP2K6 IL18 IL2 KLRD1 IL27RA IL18R1 VAV1 LGALS9 IL6 GATA3 ICOS HEL-S-92n PRKCQ IFNAR1 STAT4 TNFSF11 GRB2 CD8A PMC11125956__F8 T helper 2 Activation Pathway CD40 TGFB1 CCR5 IL33 CCR3 SOCS3 PTGDR2 TBX21 MAF IL31 CCR8 CCR1 CXCR6 IKZF1 JUN TNFRSF4 IL4 VAV1 TNLG2B RUNX3 S1PR1 ICOS CHD4 TSLP IL24 C2 PRKCQ CCR4 STAT4 GRB2 CXCR4 BHLHE41 PMC7764163__F2 Simplified canonical NFKB signaling pathway with its many deubiquitinating regulators and the molecular targets of those enzymes TRADD TAB3 RELB RIPK1 CYLD TRAF2 PMC5601171__F1 Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy FOXM1 SUFU APC PTCH1 SOX2 GSK3B SHH SMO ABCG2 UST GLI3 PMC3239343__F2 Intracellular signalling during inflammation-induced osteoclastogenesis SYK TRADD OSCAR NFATC1 TNF TRAF6 IRAK4 MYD88 TEC IL1R1 BTK TRAF5 TRAF2 PMC5696218__F10 Verrucarin J inhibits ovarian cancer and targets cancer stem cells WNT1 NOTCH1 PMC4921457__F1 Mechanisms responsible for aldosterone synthesis in zona glomerulosa cells under normal physiological conditions and excess production in primary aldosteronism ARMC5 KCNJ5 CYP11B2 ATP2B3 MC2R NACA CTNNB1 PMC4446054__F3 Top enriched network associated with BCa progression MDK RPS23 ANXA1 PTEN VEGFA IAPP RB1 IGFBP5 CAMK2N1 ITGA2 F3 HDAC5 UBE2D3 APP BIRC2 RCAN1 CYLD CCND1 PMC5601171__F5 Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy EGF EGFR PTCH1 SMO PTEN MTOR MYC PMC5601171__F3 Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy FOXM1 PTCH1 SOX2 SHH GLA SMO MTOR ABCG2 GLI3 PMC2952492__F1 Regulation of neo-vascularization by SDF-1 EPO TPO VEGFA CXCR4 PMC2774072__F7 Proposed consequences of impaired insulin signaling in AD brain and in the STZ-injected rat brain OGA OGT PTEN MTOR PMC8774031__F7 Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications POLL POLI RPL38 MTOR RPLP2 PMC8526300__F2 New Horizons for the Roles and Association of APE1/Ref-1 and ABCA1 in Atherosclerosis GULP1 MEGF10 APOE HEL-S-7 ANXA1 ABCA1 PMC86511__F9 Common and distinct activities of TGFB and BMP in C2C12 cells SMAD1 DKFZp781O1323 SMAD2 SMAD4 RUNX2 PMC9479087__F2 Polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment SLC3A2 SMS SRM SMOX PAOX PMC6067831__F1 The HPA axis CORT CRH CRHR1 PMC7990797__F6 KEGG enrichment pathways of DEGs related to IL-17 signal pathway and cytokine–cytokine receptor interaction MAPK14 TRAF4 IL17RA IL18 CCR7 IL1A CSF3 CCL20 IL23A PMC7859776__F7 An illustrative model to show the proposed mechanism of miR-126-3p promoting sorafenib resistance in HCC SPRED1 PMC11839412__F1 The relationship between CD133, AKT, and MAPK signaling in cell cycle regulation (By Figdraw TSC2 EGFR GSK3B PTEN MTOR CCND1 CXCL3 PMC11839412__F2 Roles of WNT and Notch in CD133+cell cycle regulation (By Figdraw TRPM7 LEP HEL-S-53e APC EZH2 MYC CCND1 HES1 PMC12021630__F2 Molecular mechanism of PGRN in osteoarthritis COMP SOX9 ATG12 BMP2 IHH VCAM1 RUNX2 ATG5 XBP1 SIRT1 PMC11839412__F3 Crucial miRNAs impacting CD133 and cell cycle regulation (By Figdraw DUSP5 RAB27A CCND1 CDK4 PMC11839412__F4 Other pathways involved in the regulation of CD133 and the cell cycle (By Figdraw BMI1 HDAC1 STAT3 DUOXA1 PMC1808970__F3 AIRE expression is controlled by the lymphotoxin pathway RELA RELB AIRE PMC12021630__F6 Molecular mechanism of PGRN in osteoporosis OSM HEL-S-62p CTSK OSCAR NFATC1 ATF4 RUNX2 CSF1R ACP5 PMC6482288__F3 Schematics presenting mechanisms of actions of approved and selected experimental cytokine and cytokine receptor agonists and antagonists IL1R2 IL1R1 TNF PMC12021630__F4 Molecular mechanism of PGRN in intervertebral disc degeneration RUNX2 AXIN2 IL1B CTNNB1 PMC12021630__F8 Molecular mechanism of PGRN in DOP ACAN NOS2 MTOR COL2A1 IL1B PMC4613246__F2 AKT-independent PI3K signaling in cancer BTK PTEN PMC4613246__F1 PI3K/AKT signaling pathway TSC2 BAD PTEN PMC2883337__F1 Chromaffin cell genes involved in catecholamine biosynthesis, storage, secretion and degradation TH SPR SCG2 CHGB PNMT VAMP1 PTS NPY DDC MAOA PMC6139289__F3 A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780 SOS1 EGFR NRAS ATF4 PMC8700603__F3 Association between Altered Oncogenic Signaling Pathways and Overall Survival of Patients with Metastatic Colorectal Cancer FLT3 SOS1 SMAD2 GSK3B SMAD4 MYC FGFR2 ALK NF1 DKK1 ERRFI1 FGFR4 FGFR1 RIT1 MXD3 MYCL MAPK1 ROS1 ACVR2B MXD1 MXD4 MNT APC TLE4 NTRK2 HRAS ERBB3 RHEB TSC2 SFRP4 RICTOR TSC1 AXIN1 RET SFRP5 MAX DKK4 STK11 EGFR BRAF PTEN IGF1R CTNNB1 TLE2 MGA MLX DKK2 MLXIP TLE3 ERBB4 KIT PTPN11 TCF7L1 KRAS RAC1 AXIN2 SFRP1 ARAF DKK3 CBL RNF43 PDGFRA NTRK1 ERBB2 FGFR3 MAP2K1 PMC3070484__F1 iNKT cell autoreactivity: what is “self” and how is it recognized? CD40 HEL-S-92n ICOS APC CD1D PMC8713748__F2 Systems biology analysis of human genomes points to key pathways conferring spina bifida risk STAT1 CGAS STAT2 IRF9 ROCK1 ELF2 PML SOCS3 RHO JAK1 TYK2 PMC4613246__F4 PI3K-independent AKT activation in cancer TBK1 PTK6 PTEN SRC PMC6517498__F2 Model of canonical inflammasome activation involving regulation of autophagy induced by Ehrlichia TLR9 IL1B MYD88 PMC6517498__F3 Model of regulation of inflammasome activation by type I IFNs in Ehrlichia infection IFNAR2 IFNAR1 TLR9 IL1B MYD88 PMC8931468__F6 Vanillin Derivatives Reverse Fusobacterium nucleatum-Induced Proliferation and Migration of Colorectal Cancer Through E-Cadherin/Beta-Catenin Pathway APC GSK3B CTNNB1 PMC6104135__F3 Schematic summary of HIF-1 signaling in hypoxia and diabetes NR1C1 HEL-S-133P HIF1A PMC2684527__F2 Stochasticity in Protein Levels Drives Colinearity of Gene Order in Metabolic Operons of Escherichia coli MT3 MT1M MB MT4 PMC8419281__F2 An Update on Targeted Treatment of IgA Nephropathy: An Autoimmune Perspective C6 C7 MASP2 HEL-S-62p C2 C1S PMC8319688__F4 Combining Genome-Wide Gene Expression Analysis (RNA-seq) and a Gene Editing Platform (CRISPR-Cas9) to Uncover the Selectively Pro-oxidant Activity of Aurone Compounds Against Candida albicans CYS1 GPD2 TPK1 GLG1 PGM2 HEL-S-49 HEL-S-4 PCK1 ADH5 PMC4960866__F1 Overview on the role of apolipoprotein E (APOE) in the three main pathways of plasma lipoprotein metabolism LPL ALPL APOE LDLR PMC9520939__F4 Meta-transcriptomic comparison of two sponge holobionts feeding on coral- and macroalgal-dissolved organic matter FAT4 PDIA4 RAB34 MTA3 TIGAR WDR26 TRAF3 TRAF6 IRAK4 NONO CASP3 IQUB NLK WASF2 NOP53 HSDL2 PMC3931971__F1 Simplified schematic of common mutations in the Hedgehog signaling pathway leading to basal cell carcinoma from pathway activation (a), and therapeutic targets of this pathway (b) PTCH1 SHH SMO PMC6664527__F2 The canonical Wnt signaling pathway APC GSK3B CTNNB1 PMC6021456__F7 Interaction of LBR, Rab5, Nup205, and NXF1 in the PI3K/mTOR/AKT signaling pathway RHEB RPS6 EEF2K TSC2 EIF4B TSC1 PTEN IGF1R IRS1 EIF4E LBR PMC5429720__F6 DEGs related to fatty acid degradation and PPARA signaling pathway between APFL and AP TH PPARG ESD PMC9017276__F8 mtDNA-STING Axis Mediates Microglial Polarization via IRF3/NFKB Signaling After Ischemic Stroke CGAS IRF3 ARG1 PMC6286780__F1 Zinc and zinc transporters are involved in FcERΙ-mediated mast cell activation FYN ARHA GAB2 PMC6092260__F2 MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development CDC42 BAX FRS2 CRKL MAP2 RHO MYC FOS IRS1 CRK GRB7 SHB GRB10 FRS3 BCL2 GRB2 GRB14 GAB2 PMC12221917__F2 Signaling pathway induced by TNFR2 LTA RELB TRAF3 TRAF2 PMC12007507__F2 Factors affecting DC maturation and function in NSCLC STAT3 CCL19 TLR4 NOD2 MYD88 PMC1502396__F1 The interaction between the AR and the ErbB/MAPK pathway ERBB3 JUN BAD GSK3B ERBB2 MDM2 GRB2 SHE CTNNB1 PMC6583763__F1 N-linked glycosylation in the ER EDEM3 RPN1 STT3A EDEM2 STT3B PMC2517702__F3 Signal transduction in the CD95 pathway CASP3 FADD PMC11584862__F6 Two-step model describes the transition from naïve to primed epiblast and subsequent differentiation DNMT3B FOXH1 SMAD2 SOX2 SMAD4 WNT3 PMC7565380__F3 Most important ncRNAs that regulate ER and HER2 receptors, drug efflux, apoptosis, DDR, cell cycle arrest, EMT, and CSCs features in BC drug resistance BAD EGFR BNIP3 PTEN IGF1R MTOR RPA1 CTNNB1 CD44 CDK12 CCNE1 BRCA1 ERBB2 ZEB2 CDK3 ZNF17 TINCR CCND1 PMC6568242__F2 Transcriptional Regulation of Proteasome Subunit Genes DDI1 NRF1 YAP1 DDI2 PMC9699340__F3 Constitutively Active Androgen Receptor in Hepatocellular Carcinoma FKBP5 TSC2 PHLPP1 GSK3B CTNNB1 PMC6410766__F8 Signal transduction pathways that mediate migration induced by OA in breast cancer cells EGF HBEGF EGFR SRC PMC9279298__F1 Plasmacytoid dendritic cells during COVID-19: Ally or adversary? TMPRSS2 CD80 MAVS PDC IRF3 IRF7 TLR7 IL6 ACE2 IRAK4 MYD88 PMC3631463__F8 Combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation FBXO3 TLR1 TLR4 TRAF6 TRAF2 MYD88 PMC4834358__F1 Molecular pathways and targets of the epithelial–mesenchymal transition CDH2 PTCH1 GSK3B HEL-S-28 SMO TWIST2 HIF1A ZEB2 TRAF6 TWIST1 CTNNB1 PMC4834358__F2 Hexosamine biosynthetic pathway (HBP) and glycosylated EMT targets CDH2 SNAI1 SMO CTNNB1 PMC5604128__F3 Extracellular matrix-receptor interaction signaling pathway CD44 VWF CHAD CD47 PMC7343448__F10 Mechanism of Sirt1 associated Adriamycin-resistance in DLBCL cells TFAM ND1 ND6 SIRT1 PMC3895947__F4 Wide variety of glycoconjugates such as heparin sulfate proteoglycan (HSPG), chondrotin sulfate proteoglycan (CSPG), N-glycosylated cystatin C, and galectins-1 are involved in signaling pathways inducing proliferation and self-renewal of NSCs STAT3 LIF GRB2 PMC12130087__F1 Canonical Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 CTNNB1 PMC6167374__F4 Prominent changes upon ageing in the central carbon metabolism ACLY HEL60 ENO2 IDH3B SLC25A20 RHO CS PYGL HADHB SUCLG1 SUCLA2 MSC SLC25A1 PC AGL MDH2 PFKM ECHS1 AGPS GOT2 CRAT FH ACO2 PYGB PDHX EN2 SDHA PGAM1 SDHB DLAT PDHA1 GPD2 PHGDH HEL-S-68p OGDH PFKP HEL-S-162eP HEL-S-49 SUCLG2 DLD ENO1 CPT1A PMC11876573__F6 Association network of differentially expressed genes (DEGs) in the MAPK pathway in the organ of Corti in Fkbp5−/− mice following acoustic overexposure (AO) DUSP10 EFNA4 MAP4K3 MAP2K6 RASGRP3 TNFRSF1A CACNA2D1 MAPK10 ANGPT2 TNF IL1B PMC5900450__F2 Arachidonic acid (AA) pathway of inflammation mediators LTA LOX CDA COX1 COX2 PMC11876573__F3 Association network of differentially expressed genes (DEGs) in the tumor necrosis factor signaling pathway in the organ of Corti in wild-type mice following acoustic overexposure (AO) JUN MMP14 CSF1 MAPK11 IL18R1 SELE TNFRSF1A JUNB LIF CXCL1 CXCL2 PTGS2 SOCS3 CXCL10 FOS RIPK3 MAP2K6 RELA ATF4 CEBPB IL1B PMC11876573__F5 Association network of differentially expressed genes (DEGs) in the MAPK pathway in the organ of Corti in Fkbp5−/− mice before acoustic overexposure (AO) ANGEL2 JUN MAP3K7IP1 EN1 PMC3707916__F5 Altered Protein Networks and Cellular Pathways in Severe West Nile Disease in Mice BAX NCAM1 HMGB1 GAP43 CYFIP2 CASP3 BCL2 APP CAMK4 MAP2 DPYSL3 TNF PMC11671260__F2 Multiple drug treatments that interfere with the gut microbiota PYY IRAK4 MYD88 PMC7004849__F2 Cells within the skeletal niche utilize long chain free fatty acids (LCFA) for energy generation via two complimentary cellular catabolic processes of the carnitine shuttle and Beta-oxidation PCSK9 HMGCR LDLR CPT2 PMC7723893__F1 TNFR1 activation pathway RIPK3 TRADD MLKL RIPK1 CAP1 CYLD TRAF2 PMC5700458__F1 The UPR mediators have versatile roles in different cell types either in the presence of balanced or unresolved ER stress STAT3 XBP1 PMC5707529__F2 Schematic representation of the HIV-1 life cycle TRIM50 SERINC3 HMX2 SLFN11 PMC7723893__F2 TNFR2 activation pathway TAB3 RELA TRAF1 TRAF3 PMC9926998__F8 Ozonated Water Inhibits Hepatocellular Carcinoma Invasion and Metastasis by Regulating the HMGB1/NFKB/STAT3 Signaling Pathway HMGB1 MMP2 MMP9 PMC9669482__F4 Ferroptosis and its role in skeletal muscle diseases SLC3A2 GPX4 SLC7A11 PMC8039952__F4 Approaches to turn a “cold tumor” into a “hot tumor” CD80 DCT CXCR4 PMC8570409__F5 Immunopathology and Immunopathogenesis of COVID-19, what we know and what we should learn CGAS ADAM17 NLRP3 ACE2 PMC9603380__F12 Binding of Gamma-Glutamyl Transferase to TLR4 Signalling Allows Tissue Factor Activation in Monocytes TF TIRAP TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC8138266__F5 Inhibition of the Wnt/Beta-catenin signaling pathway reduces autophagy levels in complement treated podocytes GSK3B LRP5 LRP6 PMC5810418__F7 Small Wnt Pathway Solutions to nuclear Beta-catenin, denoted by a compartment marked ‘n’ for nucleus FZD5 WNT3A APC AXIN1 LRP6 CTNNB1 PMC8419495__F4 Gene Expression Analysis Reveals Key Genes and Signalings Associated with the Prognosis of Prostate Cancer AURKA PTGER3 P2RX2 NPFFR2 TACR2 TBXA2R RRM2 CCNA2 GNA14 DRD2 ADCY3 SSTR2 CDC45 PLCB1 TTK EDNRA GNA11 EDNRB CNR1 CCNB1 PMC5810418__F8 Large Wnt Pathway solutions TLE2 APC TLE4 LRP6 TCF4 CTNNB1 PMC8570409__F3 Immunopathology and Immunopathogenesis of COVID-19, what we know and what we should learn TH RIGI TLR3 TLR4 IRF9 APC IL18 IRF3 IRF7 TLR7 IL1B MYD88 PMC5810418__F6 Small Wnt Pathway Solutions to ubiquitinated Beta-catenin, denoted by a post-translational modification with a ‘U’ APC SKP1 AXIN2 CTNNB1 PMC6321468__F2 The non-polyphenolic compounds’ major mechanisms of action on CRC cells CDC2 BAX PMC11841418__F1 3D printed magnesium silicate/Beta-tricalcium phosphate scaffolds promote coupled osteogenesis and angiogenesis GSK3B RUNX2 CTNNB1 PMC10377024__F2 Landscape of Genetic Mutations in Appendiceal Cancers FLT3 EGF ATR TGFA HGF EGFR SMAD2 GSK3B BRAF SMAD4 PTEN RHO MYC TGFBR1 CTNNB1 TGFBR2 GNAS PLCG2 ATM NOTCH3 NOTCH1 APC LRP5 LRP6 KRAS HRAS CDKN1A GNA11 GRB2 PMC10377024__F3 Landscape of Genetic Mutations in Appendiceal Cancers FLT3 EGF HGF TGFA EGFR BRAF KIT RHO MYC KRAS HRAS PLCG2 GNA11 NRAS ERBB2 GRB2 PMC10377024__F4 Landscape of Genetic Mutations in Appendiceal Cancers FLT3 EGF HGF TGFA EGFR PMC10377024__F5 Landscape of Genetic Mutations in Appendiceal Cancers TGFBR2 ATR CDKN1A ATM TGFBR1 PMC10377024__F6 Landscape of Genetic Mutations in Appendiceal Cancers FLT3 PIK3CA EGF HGF EGFR ERBB2 PTEN PMC10377024__F7 Landscape of Genetic Mutations in Appendiceal Cancers GNAS APC GSK3B GNA11 AXIN1 LRP5 LRP6 ARHA NOTCH3 MYC NOTCH1 CTNNB1 PMC10377024__F8 Landscape of Genetic Mutations in Appendiceal Cancers TGFBR2 SMAD2 SMAD4 TGFBR1 PMC4232733__F1 The IGF1R/mTOR signaling pathway resulting in growth and survival of the cell IGF1 PTEN IGF1R MTOR IGF2 PMC6321468__F1 The polyphenols’ major mechanisms of action on colorectal cancer (CRC) cells COX2 CDK2 CTNNB1 PMC10957658__F3 COX-2-PGE2 signalling pathway in RCC RAP1GAP STAT3 SRC PMC11531455__F7 A5-nAChR and SOX2 signaling cascade is involved in lung cancer progression and immune escape STAT3 SOX2 PMC10957658__F4 Membrane receptor mechanism of EET in RCC BAX HBEGF FOXO1 EGFR CYP2J2 CYP2C9 BCL2 CYP2C8 CCND1 PMC4505437__F8 CFZ inhibition of PTH-induced osteoclastogenesis PTH TRAF6 PMC4396380__F1 Reduced Tyk2 gene expression in Beta-cells due to natural mutation determines susceptibility to virus-induced diabetes STAT2 IRF1 IRF3 ATF2 STAT1 TLR3 IFNAR2 IRF2 IFNAR1 TLR8 MX1 TLR7 JAK1 TYK2 PMC8590789__F6 Cellular retinol binding protein-1 inhibits cancer stemness via upregulating WIF1 to suppress Wnt/Beta-catenin pathway in hepatocellular carcinoma EPCAM SOX2 CCND1 WIF1 CTNNB1 PMC10957658__F1 AA metabolism LTA COX1 COCH PMC8765545__F7 Exploring Long Non-Coding RNAs Associated with IP3/DAG Signaling Pathway as Potential Biomarkers Involved in Mast Cell Degranulation in Chronic Spontaneous Urticaria with 2-Year Follow-Up CDC42 CASP9 BAD COX2 PMC8193087__F1 Selenium Transport Mechanism via Selenoprotein P—Its Physiological Role and Related Diseases ARR3 PSTK SELENOP PMC4924662__F6 FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3B/Beta- catenin signaling cascade via FGFR4 activation FGF8A FGFR4 GSK3B CTNNB1 PMC7847648__F4 PPI network construction revealed the most significant modules, and signaling pathway enrichment analyses were conducted for the module genes PTTG1 BIRC5 TRIP13 FOXM1 HJURP CDC45 CENPN CDKN3 CENPE TYMS CCNB1 PMC9676466__F6 Whole genome analysis for plant growth promotion profiling of Pantoea agglomerans CPHN2, a non-rhizobial nodule endophyte TH MAK MB EMB ADA PMC6538920__F1 Wnt signaling pathways JUN APC GSK3B LRP5 LRP6 CTNNB1 CP PMC6538920__F2 Wnt signaling deregulation in the aging brain and in AD DKK1 GSK3B LRP5 LRP6 CTNNB1 PMC7713372__F4 Functional profile of main vitamin D target genes THBS1 CYP24A1 TGFBI OSM HLA-DRB1 SEMA6B STAB1 MPEG1 G0S2 CCL24 HBEGF HLA-DRA AQP9 FBP1 LAMB3 RASAL1 THBD S100A9 CYP27A1 PMC166813__F1 The GA biosynthetic pathway in pea SLN PMC7276919__F1 DNA Sensing in the Innate Immune Response TLR9 IRAK1 IRF1 IRF7 TRAF3 TRAF6 ATG5 IRAK4 MYD88 PMC7276919__F2 cGAS/STING pathway, a major cytosolic dsDNA sensing pathway mediating type I IFN signalingcGAS is localized close to the plasma membrane TBK1 CGAS IRF3 ATG5 PMC7276919__F4 RNA helicases, the proteins sensing dsDNA and the cross talk between dsDNA and dsRNA sensingDHX9 binds to CpG-B DNA through its DUF1605 domain and leads to NFKB pathway activation and proinflammatory cytokine release TBK1 CGAS MAVS DHX36 DDX41 IRF3 IRF7 TRAF6 PMC4269174__F4 Complementary metabolic pathways between the brown planthopper and its yeast-like symbiont NHS TEP1 PROC PMC8538427__F11 Polar Oxy-metabolome Reveals the 4-Hydroxymandelate CoQ10 Synthesis Pathway HPD COQ7 HPDL COQ3 COQ2 LDHD D2HGDH COQ6 COQ5 PMC5142153__F1 Summary of extrinsic, intrinsic and membrane stress apoptotic pathways BAX ATM MDM2 FADD PMC7605660__F7 The underlying mechanisms of zeaxanthin’s effects on signaling pathways and the induction of apoptosis in human gastric cancer cells CDC2 STAT3 ROS1 BAD CDK2 CCNB1 PARP1 PMC3984876__F1 Cilia in the nervous system: linking cilia function and neurodevelopmental disorders LRP5 SHH LRP6 SMO PMC6462325__F4 The effects of Cordyceps militaris on the levels of the main molecules in the TLR4/NFKB pathway in CKD patients COX2 TLR4 IL1B PMC9139434__F1 Leveraging STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate Immunity to Induce A “Hot” Tumor Microenvironment That Is Responsive to Immunotherapy TBK1 CGAS IRF3 PMC6704133__F6 Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma ITGB1 EGFR RHO SRC PMC8197226__F1 Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis DUSP10 JUN HEL70 FOS PMC8197226__F3 Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis EGF WDR62 KIF1A PMC5459509__F12 Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations GPC4 APC RHO PMC8369417__F6 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases TEC BTK BLNK CD19 NFATC1 LYN MYD88 PMC4474402__F5 Dysregulation of astrocyte extracellular signaling in Costello syndrome SNAI2 PNN ELK3 HES1 NFIA PMC8369417__F5 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases BTK TLR9 NFATC1 TLR7 LYN TNF PMC7912299__F4 Pathways to the generation of cytosolic and mitochondrial citrate and its utilization ACLY CIC FH ACO2 HMGCR GLS SLC13A5 PMC8369417__F3 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases TLR1 TLR4 IRF3 NFATC1 TRAF6 RAC1 MYD88 PMC8369417__F1 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases CDC42 SYK DCSTAMP VAV3 OSCAR CTSK BLNK NFATC1 EEIG1 TRAF6 RAC1 TREM2 BTK PLCG2 PMC7912299__F8 Mitochondrial and cytosolic pathways leading to D2-L2 hydroxyglutaric acid (D-L-2HG) accumulation (see text for explanation) CIC PHGDH L2HGDH D2HGDH HEL-S-32 MDH2 PMC6405411__F6 Signaling pathways activated by the LH surge in ovulatory follicles ERBB3 NRG1 EREG ERBB2 AREG LHCGR PMC7846784__F1 Perspectives on skeletal muscle stem cells KLF7 CXCL12 TSC2 HMGB1 HGF TSC1 PTPN11 AHR MTOR CXCR4 PMC4474305__F9 The differential subversion of type I IFN and mitochondrial apoptotic pathway by LCMV BAX TBK1 MAVS IRF3 TRAF3 PMC8627558__F2 Dynamic and cell-specific transport networks for intracellular copper ions ATOX1 ATP7B ATP7A PMC4992261__F4 5 nM PhIP activates STAT3-mediated transcriptional regulation SAA1 STAT3 POSTN ALPL EGR1 LEP SGK1 TXNIP ANGPTL2 PMC6405411__F8 PGE2 synthesis, receptors, transport, and metabolism in granulosa cells PTGER2 PTGER3 HPGD PTGER1 PTGES PTGER4 PTGS2 LHCGR PMC12153588__F5 Microtubule dynamics regulated by interconnected pathways coordinating polymerization and depolymerization CDK5 ARHA CCNB1 PLK1 PMC12153588__F6 PI3K-Akt pathway’s role in coordinating cytoskeletal dynamics during axon guidance by regulating microtubules, intermediate filaments, and actin networks RHEB LIMK2 LIMK1 MAP4 CRKL GSK3B PTEN ARHA PMC4847623__F1 Sphingolipid biosynthetic pathway ORM1 GHB3 MIP ORM2 PMC12153588__F4 Microfilament signaling pathway CDC42 LIMK2 LIMK1 ARHA PMC4058013__F3 KLK5 protease suppresses breast cancer by repressing the mevalonate pathway PCSK9 HMGCR LDLR HSD3B7 DHCR7 RHO PMC8423867__F3 N-terminal acetylation and lysine acetylation SIRT7 ESCO1 SIRT4 SIRT5 ATF2 SIRT2 ESCO2 MCM3AP CDY1B HDAC3 HDAC1 SIRT3 TAF1 MHC2TA HDAC10 HAT1 HDAC8 HDAC5 HDAC7 HDAC2 SIRT1 SIRT6 HDAC6 PMC8423867__F4 The protein acetylation in regulation of cancer-associated events STAT2 FOXO1 IRF9 ATM PTEN SKP2 PCK1 PMC9157426__F3 Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity ANGPTL4 PYY PMC8900014__F1 Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway IFNGR2 IFNGR1 IFNLR1 STAT2 IFNAR2 IRF9 IFNAR1 TYK2 PMC9420268__F1 Osteosarcoma with cell-cycle and fibroblast growth factor genomic alterations: case report of Molecular Tumor Board combination strategy resulting in long-term exceptional response CDK6 FRS2 CCND2 FGF7B GRB2 MTOR CDK4 FGF23 PMC4773096__F1 Dynamic Modeling and Analysis of the Cross-Talk between Insulin/AKT and MAPK/ERK Signaling Pathways RHEB TSC1 PTEN GRB2 MTOR PMC2926987__F3 Reconstructed antioxidant regulation pathway of detoxifying proteins TF MAPK1 CRYZ MAFK JUN MAFG KEAP1 MAPK8 FOS MAPK14 POR MAFF EPHX1 GCLC NFE2L2 ATF4 CREB1 HEL-S-44 PMC5866353__F1 Compiled summary of signaling pathways activated by prostanoid receptor PGE2 receptor 2 (EP2) in osteocytes, neurodegenerative diseases, and colon cancer (see text for details) HGF EGFR SRC CTNNB1 PMC12067647__F5 The cytokine-cytokine receptor interaction pathway in IIM patients with/without anti-MDA5+ autoantibodies CXCL12 FAS LEP LIF CD7 IL4 CXCL3 MPL TSLP INHA TPO AMH TNLG7C PMC3628025__F7 Proposed model suggesting that TGFB increases COX-2 levels and PGE2 secretion in prostate cancer cells and both TGFB and PGE2 activate PI3K/AKT/mTOR signaling pathway EGF EGFR SMAD2 MTOR PMC6447799__F3 Leptin signaling pathways STAT3 SOCS3 MTOR PMC4870076__F6 Potential mechanism underlying Qinggan Huoxue Recipe-mediated inhibition of epithelial-to-mesenchymal transition in alcoholic liver fibrosis rats SMAD2 SMAD4 PMC3636761__F1 PI3K signaling pathway and the downstream targets of Akt TSC2 BAD TSC1 GSK3B PTEN CCND1 PMC6270750__F1 Astragaloside biosynthetic pathway IPP MVP MVD PMC6175639__F8 Schematic Illustrating Potential Pathways for Glucose Utilization and Energy Production by Tendon Cells EGF HEL-S-133P SMAD2 HIF1A PMC5831777__F3 Hh signaling within the developing TMJ SOX9 PTCH2 PTCH1 IHH SMO COL10A1 RUNX2 COL2A1 GLI3 PMC10152377__F1 Somatic Variants Activating Ras/Raf/Mitogen-Activated Protein Kinase (MAPK) Pathway Genes in Mesial Temporal Lobe Epilepsy NF1 GRB2 PMC10346897__F4 Mechanism by which PUFAs suppress cholesterol synthesis via inhibition of the signaling pathway of sterol regulatory element-binding protein-1 (SREBP-1) [74] ABCG1 FAS ABCG8 ABCG5 INSIG1 PMC5958547__F1 New Opportunities and Challenges to Defeat Cancer Stem Cells STAT3 CXCR1 SMO PMC10845654__F8 Working model PAQR7 BAX PMC4407014__F4 An incomplete engagement of the TCR pathway differentiates BT-061 from other anti-CD4 mAbs UNK PMC2710138__F8 Feedback inhibition of the phosphatidylinositol 3—kinase (PI3K) pathway RHEB MLST8 TSC2 RICTOR PTEN MTOR PMC9929207__F4 MAPKAPK2-centric transcriptome profiling reveals its major role in governing molecular crosstalk of IGFBP2, MUC4, and PRKAR2B during HNSCC pathogenesis ZFP36 ELAVL1 MAK MAPKAPK2 PMC2710138__F2 Phosphatidylinositol 3—kinase (PI3K) signaling pathway CDC42 RHEB TSC2 BAD TSC1 PTEN MDM2 RAC1 PMC4900191__F2 Regenerative Medicine: Charting a New Course in Wound Healing PROP1 MAP3K7IP1 MYC CYLD PMC6347283__F1 Representation of signaling pathways upstream of MTORC1 RHEB MAPK1 TSC2 TSC1 MAPK13 DDIT4 TBC1D7 PTEN RRAGA IRS1 MAPK3 PMC6347283__F2 Effectors downstream of MTORC1 MTHFD2 STAT3 RPS6 PPARG EIF4B CAD GLS MCL1 SIRT4 HIF1A ATF2 YY1 MYC EIF4E GLUD1 EEF2K PHGDH EEF2 PC BCL2 PPARGC1A ATF4 ASNS PMC8894463__F8 Schematic illustrating the mechanism by which TRIM45 regulates cerebral I/R injury by activating NFKB signaling in microglia MAP3K7IP1 TRIM45 PMC7509400__F2 Immune functions of GD T cells in cancers FAS MICA MICB IL1B PMC6068089__F9 Schematic depicting neuroprotective roles of BRCA1 towards I/R injury BRCA1 GPX4 GCLC PMC3222593__F2 Pathway Studio® (Ariadne Genomics) was used to identify known relationships among human homologues of the genes identified as differentially regulated by ANOVA TH HDAC1 NR1C1 HEL-S-302 HEL-S-162eP MYC INS FOS PS1TP5BP1 GPT PMC8072347__F1 OSCAR Signaling in Osteoclastogenesis and Bone Disease TEC BTK BLNK NFATC1 SRC TRAF6 PMC4594952__F3 Concise review on the current understanding of pancreatic cancer stem cells CD44 EPCAM FOXM1 DKK1 APC SOX2 GSK3B SHH HES1 CTNNB1 GLI3 PMC6788756__F2 Functions of the calcineurin signaling pathway in S GPX2 SIM1 SIM2 MID1 HEL-S-84 HEL-S-11 RCN2 HES1 YAP1 VPS36 PMC11523277__F1 Effect of ubiquitination imbalance on osteosarcoma cells and its clinical application TRIM46 ARIH1 RNF180 USP1 TRAIP MDM2 USP9X TRIM21 PMC11523277__F2 Ubiquitin-mediated regulation of key signaling pathways in tumor cells RNF7 USP19 ITCH OVOL2 UBE2T TRIM21 MKRN1 FBXW7 USP33 SPOP RNF43 USP3 USP4 MLF2 USP2 TRIM37 CUL4B ZNRF3 TRIM66 MDM2 USP16 PMC8471964__F6 Idebenone Decreases AB Pathology by Modulating RAGE/Caspase-3 Signaling and the AB Degradation Enzyme NEP in a Mouse Model of AD ADAM17 BACE1 APP PMC11523277__F3 Dysregulated ubiquitination pathway drives osteosarcoma malignancy RNF180 PCNA KEAP1 CBX4 TRAIP MTOR SKP2 RUNX2 TRIM21 CTNNB1 NLRP3 CDK7 ALKBH5 USP1 MYCBP MDM2 A1BG HEL-S-43 POLE2 KLF6 ARHA USP9X CHPF MEF2D CD44 L3MBTL2 TRIM46 ARIH1 USP22 SIRT1 PMC3621012__F2 Regulation of miRNA biogenesis and turnover in the immune system MYB IRAK1 TRAF6 MYC PMC5072418__F1 Proposed Pd0/PdII catalytic cycle for aryl fluorination PDF ARX PMC5918594__F4 Proinflammatory challenge and anti‐inflammatory drugs on expression of genes related to tryptophan and kynurenine metabolism SLC3A2 TPH1 GOT2 IDO1 KYNU KMO HAAO SLC7A5 AFMID SLC16A10 MAOA PMC5371895__F1 Schematic metabolic model showing important pathways after proliferation of Streptococcus suis serotype 2 in porcine blood (A) and cerebrospinal fluid (CSF) (B) GAL PTS CIT PMC2796203__F1 Targeting the Transforming Growth FactorB Signaling Pathway in Human Cancer CDC42 TF EGF GSK3B TGFBR3 RHO STRAP TGFBR1 PMC2796203__F2 Targeting the Transforming Growth FactorB Signaling Pathway in Human Cancer SMAD2 SMAD4 TGFBR1 PMC11523277__F4 Potential of ubiquitination modulation in osteosarcoma treatment RAD18 DDRGK1 TRIM46 FBXW7 TRIM28 RNF4 USP1 SOX2 ZNRF3 RAB22A PMC3287202__F6 Overview of pre-miRNA processing LIN28A AGO2 DICER1 DROSHA PMC11833784__F5 Schematic representations of energy metabolites and enzymes involved in glycolysis, TCA cycle, ETC and AMPK pathway in ileum of layer pullets TFAM CS NRF1 PMC6916690__F2 Signaling pathways and cross talk, regulated by E-cadherin EGFR ARHA MTOR TNF RAC1 PMC12035655__F10 Novel Wnt/Beta-catenin signaling gene signature for progression and metastasis of gastric cancer TCF3 AEBP1 HEL113 CPZ FZD2 CTNNB1 PMC6505469__F10 Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro ATF4 TRIB3 PMC2671916__F6 Novel functional modules with dynamic gene expression changes potentially linked to prion pathophysiology: (A) androgen metabolism, (B) iron metabolism, (C) arachidonate/phospholipid metabolism LTB LTA AMPD3 DBI HSD3B7 HFE PMC3618522__F1 Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway In Cancer Prevention and Treatment RARA FABP5 RARB CCND1 PMC3913495__F1 IL-6 exerts its pleiotropic activity by activation of gp130 through its binding to transmembrane or soluble IL-6 receptor CRP STAT3 GRB2 PMC3618522__F2 Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway In Cancer Prevention and Treatment RARA RARB PARP1 PMC6963578__F2 Schematic diagram of interactions between arenavirus proteins and host innate immune machinery TBK1 IRF3 EIF2A PMC5742799__F2 Hypothetical model for the proposed anti-inflammatory role of MUC1 in response to P TGFA SP1 EGFR MUC1 IRAK1 TLR5 TRAF6 TNF IRAK4 MYD88 PMC5759160__F3 Schematics of the Wnt/Beta-catenin signalling pathway APC GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC8134663__F2 Unraveling the Role of the Apical Papilla During Dental Root Maturation HHIP WNT3A APC LRP5 SOX2 LRP6 RUNX2 CTNNB1 FGFR2 DSPP NOTUM FGFR1 SHH WNT4 PMC7697917__F8 BDNF pathway STAT3 RELA NTRK2 AHR BDNF HDAC2 FOS PMC5849167__F5 Ang-2 up-regulating EMT and facilitating lung cancer metastasis NOS2 HEL113 TGFA ADM HEL-S-68p HEL-S-162eP EPO ENO1 MTOR IGF2 VHL PMC8132202__F4 Risk prediction model of gene signatures in ovarian cancer through bagging of GA-XGBoost models MSMB PDGFD NRK VAV3 IGFBP4 PID1 VCAN FNDC1 FIGN HIF3A SYTL2 INHBA MFAP4 IGFBP5 SYTL5 INPP4B PCSK5 RAB1 GHR NDNF PMC5504240__F1 Circadian metabolites have pleiotropic mechanisms by which to maintain cellular rhythmicity NPAS2 SIRT3 PER2 ME2 GPR176 VIPR2 MTOR SIRT1 SIRT6 PMC3133259__F1 The CoA biosynthetic pathway PPCS PPCDC PMC3248184__F1 YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention GSK3B SRC PMC5352107__F4 Triple-negative breast cancer: is there a treatment on the horizon? EGFR FACL4 MTOR PMC8479803__F1 Vascular smooth muscle cells in atherosclerosis: time for a re-assessment KLF4 ACTA2 SOX9 CD36 DKFZp686P11128 MYOCD TCF21 SCAI RUNX2 CD68 PMC7486896__F8 Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/Beta-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma MMP7 SP1 MMP2 CTNNB1 PMC8357478__F9 Tianma Formula Alleviates Dementia via ACER2-Mediated Sphingolipid Signaling Pathway Involving AB TF CDC2 PDK4 PMC5466513__F1 Autophagy in UV damage response RHEB ATG10 TSC2 ATG3 TSC1 ATG12 ULK1 UVRAG PTEN SESN2 ATG5 PMC8307504__F6 Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation TBK1 CGAS IRF3 PMC5571543__F8 Proposed mechanism of ESA‐mediated downregulation of Foxp3 in regulatory T cells SMAD2 SMAD4 FOXP3 PMC4263025__F1 RAF fusion genes in prostate and gastric cancer and melanoma ESRP1 RAF1 BRAF AGTRAP PMC8430084__F2 Neutrophil extracellular traps (NETs): the role of inflammation and coagulation in COVID-19 TF VWF TFPI PLG FDPS ADAMTS13 PMC6592994__GA Biological role of MALAT1 in cyclin D1, miR-363-3p and Mcl1 gene regulations MCL1 APC CCND1 CTNNB1 PMC3313594__F3 Targeting blood–brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery TF SMAD1 DKFZp781O1323 SMAD2 PMC9138253__F3 Cross-Talk between Wnt Signaling and Src Tyrosine Kinase CDC42 ROR1 HEL113 TRIO APC ROR2 GSK3B LRP5 LRP6 ARHA SRC CTNNB1 PMC3313594__F5 Targeting blood–brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery SMAD1 DKFZp781O1323 SMAD4 PMC1817809__F1 AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues HEL-S-5 AgRP MTOR PMC4609654__F1 The Wnt signaling pathway with selected inhibitors WNT10B RNF43 APC GSK3B WNT1 CTNNB1 PMC9138253__F6 Cross-Talk between Wnt Signaling and Src Tyrosine Kinase ROCK2 ROCK1 GSK3B LRP5 LRP6 ARHA SRC CTNNB1 PMC1817809__F2 AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance CNTF HEL-S-5 MTOR PMC3322992__F8 Pathways required for the role of CDCP1 in EGF/EGFR-induced cell morphological changes and increased cell migration EGF EGFR CDCP1 PMC8926078__F1 Non-Coding RNAs in Autophagy During Carcinogenesis HMGB1 EGFR ULK1 UVRAG ATG14 BNIP3 PTEN STX17 ATG101 ATG10 TSC2 ATG3 TSC1 ATG12 AMBRA1 ATG5 ULK2 PMC6828502__F1 Dual pathway for metabolic engineering of Escherichia coli to produce the highly valuable hydroxytyrosol DDC PMC2735908__F8 Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway WNK1 WNK4 SGK1 DCT OSR1 PDK2 PMC12230486__F4 Metabolic Adaptations and Therapies in Cardiac Hypoxia TXN FH GLS HEL-S-133P SHD PAX5 F2 HK2 SIRT4 TIGAR MYC HEL-S-51e PMC6499784__F4 Schematic representation of a proposed model of the TBS pathway interaction with PET CYB PC FECH PMC8249349__F1 Metabolic alterations in pancreatic cancers RPE GOT2 RPIA GLS HK2 MAL HEL-S-32 ME1 CIT PMC8249349__F2 Pancreatic cancers rely on autophagy and lysosomal scavenging ATG101 ATG3 ATG16L1 ATG12 ULK1 ATG14 MTOR STX17 ATG5 PMC9068506__F3 Association of Gut Microbiota with Inflammatory Bowel Disease and COVID-19 Severity: A Possible Outcome of the Altered Immune Response MAVS STAT2 IRF9 TLR8 TLR7 ACE2 MYD88 PMC6854743__F8 Signaling pathway of the Akt + diuron-induced glioma PCNA UHRF1 PMC7266824__F2 Ibrutinib in Chronic Lymphocytic Leukemia: Clinical Applications, Drug Resistance, and Prospects STAT3 SYK MTOR IL6R IKBKG BTK BCL10 BCR PLCG2 RELA IKBKB NFKBIA LYN JAK1 PMC12230486__F1 Under Hypoxic Conditions, The Energy Metabolism of Cardiomyocytes ChangesMany of the discussed pathways show protection against ischemia-reperfusion injury (IRI) (green arrows) or are protective if blocked (red arrows) TXN IKZF1 FH GLS HEL-S-133P SHD PAX5 F2 SIRT4 TIGAR MYC HEL-S-51e PMC11352684__F4 TRIM proteins in the cellular signaling pathway of MAFLD TRIM16 TRIM31 TRIM38 GPX4 FASN TAB3 HIF1A TRIM59 TRIM21 TRIM24 CEBPD TNIP3 TRIM67 TRIM8 RHBDF1 SNX8 SIRT1 TRIM65 PMC12230486__F2 Metabolic Adaptations and Therapies in Cardiac Hypoxia NR1C1 PDK4 CD36 HIF1A PMC5722516__F7 Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/CIP2A axis CIP2A MTOR PMC12230486__F3 Metabolic Adaptations and Therapies in Cardiac Hypoxia VEGFC CD36 VEGFA TIMD4 MERTK PMC9654020__F1 Looking into Endoplasmic Reticulum Stress: The Key to Drug-Resistance of Multiple Myeloma? CAMKK2 MCU ATF4 MTOR XBP1 TRAF2 PMC10572085__F2 Signaling pathways of the CD44 intracellular domain (CD44-ICD) under hypoxia CD44 PFKFB4 ECD SOX2 RUNX2 CCND1 PMC10572085__F3 Signaling pathway activated by HA-CD44 interaction CDC42 CD44 EGFR ERBB2 RHO RAC1 PMC6130388__F6 Schematic of proposed model IL16 IL1B PMC4850468__F1 Molecular Mechanisms of EndoMT COMP TIMP1 SMAD2 PTCH1 SHH SMAD4 SMO HIF1A NOX4 NOTCH1 PMC10572085__F5 HA-CD44 binding-activated signaling pathways CD44 SOX2 BCL2 PMC8485759__F4 Purine synthesis and its dependency on mitochondrial metabolism PAICS MTHFD1 HEL-S-70p ADSL PMC12211383__F1 Sources and metabolic functions of serine PHGDH SHMT1 PSAT1 HEL-S-51e PSPH PMC11815735__F9 Proposed mechanism elucidating the involvement of EBV in oral cancers encompasses the regulation of host cellular lncRNA LINC00944 CXCL9 STAT1 CD80 CCL3 IRF1 CXCL10 PMC5630322__F7 Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma EGF EGFR MSC PMC7641864__F7 Metabolomics analysis of the mechanisms of hUCMSC treatment for POI APOA2 OMP AIRE PMC10388466__F7 Peptidase inhibitor (PI16) impairs bladder cancer metastasis by inhibiting NFKB activation via disrupting multiple-site ubiquitination of NEMO SHARPIN ANXA1 PI16 PMC7026421__F1 Rho-ROCK signaling mediates entotic cell death in tumor FH DAP RHO PMC7586277__F7 Pathway leading to phagocytosis of senescent AD-MSCs NLRP3 HEL-S-62p C3AR1 TXNIP IL16 TLR4 IL18 CD14 PMC6721448__F3 BRAF-mediated signaling in normal and cancer cells HGF NF1 EGFR BRAF MTOR CDK4 PMC3196116__F10 Proposed model shows the requirement of the IL-4RAlpha-Jak2-mediated signaling pathway for IL-13-induced M2 gene expression in human monocytes/macrophages STAT3 STAT1 CD36 PMC9381384__F1 Clinical, phenotypic and genetic landscape of case reports with genetically proven inherited disorders of vitamin B12 metabolism: A meta-analysis MMAA MMACHC MMADHC ABCD4 MTR LMBRD1 PMC7779201__F3 Hypothesis of Apatinib acquired drug‐ resistance mechanism caused by WRN point mutation ROS1 WRN PTEN MDM2 PMC8763889__F2 Carcinogenic mechanism of TFF3 LINGO2 CDH2 STAT3 BAX BAD COX1 PGR EGFR GSK3B TERT MTOR RHO TFF3 ARAF BCL2 IL8RB CXCR4 PMC5773092__F7 Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers HRAS BRAF SHH KRAS PMC9114637__F1 Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis ACAN IL1R1 PIEZO1 PMC3099033__F9 Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling RHEB RPS6 TSC2 TSC1 PMC8956597__F3 Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer BAD SHC1 ABL2 EGFR AKT3 RPS6KB2 GSK3B PAK4 BRAF MTOR MYC NCK2 PAK6 SRC CCND1 MAPK1 JUN NCK1 CRKL ARAF CDKN1A CAMK2D PAK1 RPS6KB1 MAP2K2 GRB2 CAMK2G PMC5499671__F3 TGFB regulation of T cells in multiple sclerosis TGFBI SMAD2 SMAD4 FOXP3 PMC8956597__F4 Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer BAD SHC1 SOS1 ABL2 EGFR AKT3 RPS6KB2 GSK3B PAK4 BRAF MTOR MYC NCK2 STAT5B PAK6 SRC CCND1 MAPK1 JUN NCK1 CRKL ARAF CDKN1A CAMK2D PAK1 RPS6KB1 MAP2K2 GRB2 CAMK2G PMC8956597__F5 Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer BAD SHC1 SOS1 ABL2 EGFR AKT3 RPS6KB2 PAK4 BRAF MTOR MYC NCK2 PAK6 SRC CCND1 MAPK1 JUN NCK1 CRKL ARAF CDKN1A CAMK2D PAK1 RPS6KB1 MAP2K2 GRB2 CAMK2G PMC6281578__F8 LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA PIK3CA RXRA GSK3B PMC2774878__F2 The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis CXCL12 EGF CXCR4 VHL PMC3195753__F3 Comparative analysis of plastid transcriptomes in cucumber RPS15 MATK RPS19 RPL36 RPS18 RPS7 RPS11 RPS8 CYB CLPP PC RPL14 RPL22 PMC5988607__F3 Regulators of MST1 and MST2 LATS1 LPA LATS2 C2 PMC7047199__F1 Radiation-induced effects on pathways related to mitochondria in cardiac cells BAX NR1C1 GSTA4 KEAP1 PGAM5 PMC8921539__F4 Hypoxia and chronic kidney disease KEAP1 EPOR EGFR EPO VHL PMC10867724__F4 Demonstration of the TNF signaling pathway and the target to be tested JUN TRADD ITCH SELE MLKL CASP3 NOD2 TNF CYLD TRAF2 FADD PMC4349561__F2 Pathway analyses of direct interactions among transcripts mediated by P4 in the ovary SPEN TRAF4 CD59 PGR PAK1 MYH9 PGRMC1 SNX9 PMC4349561__F3 Pathway analyses of A) tumor protein p53 (TP53) B) E2F transcription factor 1 (E2F1), and C) miRNA 124-1 TRAF4 CDKN2A MYB PKD1 FEN1 IFRD1 MYBL2 POLI MCM5 TOP2A PMC6198132__F3 Hypothetical scheme for the unfolded protein response-induced signaling cascade in MANF-deficient beta cells RFWD2 CSA2 BCL10 ATF4 EIF2A TRIB3 XBP1 TRAF2 PMC3444501__F4 Therapeutic Effects of Astragaloside IV on Myocardial Injuries: Multi-Target Identification and Network Analysis CRP STAT3 HPSE EGF TGFA EGFR BST1 KIT CD40LG RAC3 NCF1 MAPK14 ALB ENG MME NF1 F2 HEL-S-162eP DAPK2 MAPK12 HLA-A ACE2 SELP PMC9104445__F8 Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway MMP7 NGF MMP9 PMC4947819__F2 SOX2-mediated sensing of cytoplasmic DNA and the associated signaling pathway in neutrophils SOX2 ATF2 IL1B PMC8959092__F3 Repurposed drugs targets in ovarian cancer COX2 SOX2 MTOR PMC7894323__F6 Infigratinib and ribociclib in inducing differentiation and preventing dedifferentiation CDC2 CDK6 FRS2 SOX9 CDK2 GRB2 MTOR CCND1 CDK4 PMC11629812__F6 S‐Nitrosylation of NOTCH1 Regulates Mesenchymal Stem Cells Differentiation Into Hepatocyte‐Like Cells by Inhibiting Notch Signalling Pathway HES1 NOTCH1 PMC8523946__F3 MiR-873-5p: A Potential Molecular Marker for Cancer Diagnosis and Prognosis JMJD8 PLEK2 TUSC3 APC GSK3B CXCL16 PTEN MMP9 MTOR TNF KRAS NDFIP1 CTNNB1 MAP3K7IP1 HOXA9 TRAF5 GRB2 TRAF2 PMC12112582__F4 Illustration shows the GPCR signaling pathway exploited by neuropeptides in insects to transmit signals regulating various physiological processes, including the mating behaviors PDF NPS PROC PMC8521155__F1 The Complement System by Neoplastic Disease of the Central Nervous System CD59 HEL-S-62p C2 CD46 CD55 PMC4224453__F10 miR-18a Inhibits CDC42 and Plays a Tumour Suppressor Role in Colorectal Cancer Cells CDC42 PHLPP2 PTEN RAC1 PMC7877185__F3 Competing endogenous RNAs (ceRNAs) and the signaling pathways involved in lung cancer cell invasion and migration BRD4 EGF SLC12A5 MYEOV HMGA2 ZFHX4 EGFR SMAD2 GSK3B SMAD4 PTEN MTOR RUNX2 TGFBR1 MMP11 CTNNB1 TGFBR2 ADAM15 MMP2 ZEB2 CDH2 MADD MMP7 SMS GSKIP TGFBR3 EZH2 MMP9 VEGFA FOXO1 PMC7877185__F1 Competing endogenous RNAs (CeRNAs) and the signaling pathways involved in lung cancer cell proliferation EGF PCNA E2F2 RRM2 PTEN CCNA2 MYC SKP2 IGF2 IRS1 CDK6 E2F3 CDK2 CYLD PMC7404143__F5 Roles of NRP2 in SMC phenotypic switching NRP2 ARHA PMC3084021__F1 Conservation of the RB and Hippo signaling pathways in humans and fruit flies LATS2 MCM3 CDK2 CDK4 PMC6441712__F7 Effects of SIRT2/cMYC pathway in CCA cells.SIRT2 and cMYC reprogrammed the metabolism of CCA cells by up-regulating downstream p-PHDA1 and PHGDH/PSAT1/PSPH PDHA1 PHGDH SIRT2 PSPH PMC7404143__F3 Endothelial cell NRP2-mediated signalling pathways ANGPTL4 SMAD2 NRP2 RRAS ARHA VEGFA TGFBR1 PMC523224__F6 Metabolic pathway leading to generation and detoxification of MG HEL107 RPE MAOA PMC8293794__F1 New developments implicating IL-21 in autoimmune disease IFNG STAT3 STAT1 IL21R PMC8738868__F4 Emerging commonalities of circRNA-mediated signaling pathways APC GSK3B CTNNB1 PMC8293794__F2 New developments implicating IL-21 in autoimmune disease STAT1 JAK3 JAK1 PMC6052012__F4 Metabolic construction of the putative pathway for AOM coupled to Fe(III) reduction in “M CYB C2 MTR PMC4835044__F8 Schematic depicting the Arg-auxotrophic response ASS1 AXL GSK3B BRAF PMC9413556__F1 Targeting IRE1Alpha-JNK-c-Jun/AP-1-sEH Signaling Pathway Improves Myocardial and Coronary Endothelial Function Following Global Myocardial Ischemia/Reperfusion ATF4 EIF2A XBP1 PMC3591455__F5 Essential Role of the Zinc Transporter ZIP9/SLC39A9 in Regulating the Activations of Akt and Erk in B-Cell Receptor Signaling Pathway in DT40 Cells SYK BTK BLNK CD19 LYN GRB2 PMC6865334__F8 Potential pathway for enhanced invasion upon mechanical stimulation PAK1 LIMK1 RAC1 PMC10991915__F4 Physiological and transcriptome analysis elucidates the metabolic mechanism of versatile Porphyridium purpureum under nitrogen deprivation for exopolysaccharides accumulation RPE MAL PDC CIT PMC5385655__F6 Schematic representation of the effect of S3I-201 in obesity-induced extensive mammary hyperplasia STAT3 MMP2 PMC8489683__F1 Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node TFAM FOXO1 FOXO3A NAMPT HIF1A NRF1 VHL PMC4673623__F1 Simplified diagram of one-carbon metabolism (1-CM) including the methionine cycle, the roles of one-carbon nutrients, and links to lipid metabolism PEMT PC HEL-S-61p PMC7140716__F1 Role of ARTS and Smac in induction of apoptosis TRADD TRAF2 FADD PMC7140716__F2 Models for Smac-mimetic (SM) and ARTS-mimetic (AM) mode of action RIPK3 TRADD RELB RIPK1 TRAF3 TRAF2 FADD PMC4922058__F4 Illustration of metabolic pathways reported to have altered gene and metabolite expression by integrated pathway analysis (MetaboAnalyst) ALDH2 LPCAT2 AGPAT4 LDHB ME1 CHKA PMC4354890__F1 Causes and Consequences of Replication Stress DDT ATR MCM7 ATRIP PCNA MCM3 MCM5 MCM6 MCM2 PMC2854673__F1 Minimally oxidized LDL induces TLR4-dependent lipoprotein uptake by macrophages CDC42 SYK TLR4 CD14 VAV1 RHO PMC8348875__F8 Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE) BAX CCND1 CDK4 PMC9675355__F5 Regulators of nucleotide excision repair (NER) in melanocytes XPA ATR MC1R EDNRB XPC PMC4676710__F1 A and B, top two networks of proteins eliciting a significantly elevated (P < 0.01; mean ratio > 2) autoimmune response in WHI human prediagnostic TNBC samples, based on Ingenuity Pathway Analysis POR FOS CTNNB1 PMC4676710__F3 And B, top two networks of proteins eliciting a significantly elevated (P < 0.01; mean ratio > 2) response in C3(1)-T TNBC mouse model samples collected before palpable tumor compared with baseline, based on Ingenuity Pathway Analysis ESRRA HEL-S-43 NFYA TRIM2 STXBP3 PMC4694982__F9 By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis EPCAM JUN FOS PMC2670521__F9 New Microbicidal Functions of Tracheal Glands: Defective Anti-Infectious Response to Pseudomonas aeruginosa in Cystic Fibrosis FHL3 SP1 RPS6KC1 PRPH2 SPHK1 NRAP CTNND1 FHL2 SMPD1 PECAM1 SFTPB ASAH2 BCL2L1 PRKCE SPHK2 NPC1L1 HEL-S-5 SP3 FHL1 SNW1 LYN SRC TRAF2 LCK PMC4698256__F1 Proposed cytotoxic mechanisms of NEDDylaton inhibition in human malignancies WEE1 CDT1 MTOR DEPTOR PMC4896925__F2 Localization of AKAPs in T cells PMC6875203__F3 Cross talk between induction of mitochondrial oxidative/nitrosative stress and autophagy HMGB1 MID1 TFEB C19orf12 ATM SHE PMC9148418__F6 Pharmacological modulation of healthy aging with urolithin A, NAD+, resveratrol and spermidine SIRT3 NRF1 SIRT1 PMC7966414__F1 Simplified metabolism of Lupinus albus nodules and cluster roots under P and N deficiencies CS PMC3730487__F2 Two mechanisms of phase II xenobiotic-metabolizing enzyme induction by phase II inducers MAF AHR NRF1 PMC8989838__F6 Metabolic Reprogramming of Alloreactive T Cells Through TCR/MYC/mTORC1/E2F6 Signaling in aGvHD Patients HEL-S-162eP MYC PFKM PMC3347034__F3 Inhibition of type I IFN signaling by DENV: IFNA/B binds the type I IFN receptor (IFNAR), which is composed of IFNAR1 and IFNAR2 and is found on the surface of nucleated cells STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC3998185__F7 Metastatic Stem Cells: Sources, Niches, and Vital Pathways CXCL9 STAT3 EGF TNC CXCL12 SMAD1 CSF1 HEY2 EGFR CXCL1 S100A8 LOX IL11 VCAM1 PLOD2 IL8RB SRC CXCR4 GPR49 CSF1R PMC5436704__F3 Cell–cell communication and cyclic AMP coordinates oocyte meiotic maturation in worms and mammals DAB1 PDE3A VAV1 PMC7993611__F1 Hypopigmented burn hypertrophic scar contains melanocytes that can be signaled to re-pigment by synthetic alpha-melanocyte stimulating hormone in vitro MC1R PC DCT TYRP1 PMC7912475__F2 Impact of Maternal Food Restriction on Heart Proteome in Appropriately Grown and Growth-Restricted Wistar—Rat Offspring COMP ARPC2 AGTR1 HEL-S-28 ARHA MYLK ACTR2 ENG TTN APLN MAP2K2 GRB2 RRAS2 ACE2 PIKFYVE PMC7088938__F4 Fusion hallmarks: trends in cellular pathways fusions by fusion event cluster NGF ERBB4 IGF1R RHO PMC7464402__F8 Apoptosis signalling pathway and cell cycle arrest in response to Moringa extract and 3-HBI BAX BAD PAF1 PMC12061513__F4 Protein palmitoylation modifications are involved in regulating osteogenic matrix mineralization and differentiation signals BMPR2 SMAD1 FKBP11 DKFZp781O1323 BMPR1A SMAD4 IFITM5 RUNX2 PMC4951290__F1 Nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells LPL HEL-S-133P MSMO1 SPTLC3 FASN DHCR24 PCCB ME1 ME3 PCK2 PGAM1 HMGCR PHGDH HEL-S-32 ENO1 MDH2 TM7SF2 GPT PMC11548906__F2 Regulation of adipogenesis in lipedema GATA2 PPARG SMAD1 CSF1 DKFZp781O1323 SMAD4 MEDAG NEGR1 BICC1 SIRT2 LYPLAL1 ADD1 LOX SEMA6D CEBPB CSF1R ACP5 FBN1 ERBB4 LIF EMILIN2 GATA3 FGF2 SFRP1 CEBPA MRC1 IGF1 SIRT1 CD68 PMC10383192__F1 Peptide Vaccine Design Targeting KIT Mutations in Acute Myeloid Leukemia BAD KIT MTOR SRC PMC9127082__F1 Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells GPX4 ALOX15 SLC7A11 DHODH PMC7281113__F1 HOTAIR role in breast cancer (BC) drug resistance mechanisms with details of the main molecular pathways involved HOXD10 TFF1 BAD PTEN CTNNB1 PMC7281113__F2 Main cellular processes inhibited or activated by the silencing of HOTAIR in BC cells HOXD10 PCDH10 BAD BCL2 PTEN MTOR CCND1 VCAN GATA3 PMC11632373__F1 Biosynthetic pathway of GPI-APs PIGP PIGC PIGH B3GALT4 PIGU PGAP1 PIGT PIGO PGAP2 PGAP3 PIGN PGAP4 PIGW PIGY CLPTM1L PIGX ARV1 PGAP6 PIGK GPLD1 DPM2 PIGV PIGF PIGA PIGB PIGL PIGS PIGM PMC5572180__F3 Alterations to the phosphatidylinositol-3-kinase (PI3K)/Akt signalling pathway and outcome prediction in ovarian clear cell carcinoma (OCCC) PIK3CA PIK3R2 PIK3R1 PTEN PMC7852150__F1 Metabolic features of hPSCs ACO2 FASN PSAT1 PMC5228426__F2 Most highly-rated network of microRNA-1297 target genes in Ingenuity Pathway Analysis NTRK3 PTEN SNCAIP MEF2C RB1 NAIP IGF1 CDH11 ELF1 ATXN1 MEIS1 TRIM45 ZHX1 EPC1 CYLD ZNF268 CP MYBL1 PMC3642326__F7 CQ excites TRPA1 and TRPC3, sensitizes TRPV1, and inhibits TRPM8 through different signaling mechanisms TRPA1 TRPV1 TRPC3 TRPM8 PMC7015249__F9 Serum amyloid A 1 (SAA1) induced muscle atrophy SAA1 TLR1 TLR4 RELA CSK IL6 PMC9532536__F8 Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway CDC2 FOXM1 KIF20A A2M CCNB1 PLK1 PMC6013765__F3 “threshold model”, as exemplified by the FGF8-FGFR system, can explain disparities in transcriptional activity EN2 FRS2 GBA2 PMC8558176__F1 WNT3 hypomethylation counteracts low activity of the Wnt signaling pathway in the placenta of preeclampsia APC GSK3B LRP5 LRP6 CTNNB1 PMC9534556__F2 Potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry ACHE BAX ChAT PMC6602412__F2 M6A on the AKT signaling pathway PRR5 PHLPP2 MTOR PMC6602412__F3 M6A on the JAK/STAT signaling pathway STAT3 STAT1 JAK3 JAK1 PMC8458633__F8 Network Pharmacology and Experimental Validation Reveal the Effects of Chidamide Combined With Aspirin on Acute Myeloid Leukemia-Myelodysplastic Syndrome Cells Through PI3K/AKT Pathway HRAS CASP3 CDK2 CCNA2 MMP9 SRC CDK4 PMC7229175__F7 BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis TIRAP TLR4 ARF3 MYD88 PMC7312764__F6 Analysis of the major constituents in SHED-CM and the plausible mechanisms of SHED-CM-mediated neuroprotective effects ROBO3 MAPK11 TGFB1 HOMER1 CALM1 IGFBP2 PTEN OPRM1 BMP5 IGFBP6 KLC2 PMC7485335__F2 ICOS signaling pathway in Tregs CXCR3 ICOS CD80 APC GSK3B FOXP3 PMC9184479__F6 Central metabolism of C. albicans is altered by L. rhamnosus colonization ALPL HEL-S-162eP MAL CS CIT PMC7827874__F2 Transforming growth factorB (TGFB) superfamily signaling in PAH CDC42 TGFBR2 SMAD1 DKFZp781O1323 NODAL ARHA ID1 PMC8093614__F1 PD-1 Immune Checkpoint Inhibitor Therapy Malignant Tumor Based on Monotherapy and Combined Treatment Research APC PMC7827874__F4 Endothelial to mesenchymal transition (EndoMT) in PAH CDH2 VWF MMP2 MMP9 PMC12245985__F7 Late‐stage DMD skeletal muscle transcriptomic changes in TGFB signalling pathway HCAR2 SFRP4 SMAD1 TGFB1 DKFZp781O1323 SERPING1 BMP4 SMAD4 ADAM12 DMD UNC13C PMC9052997__F1 An adult case of NOTCH3 mutation in pulmonary artery hypertension NOTCH3 RBPJ PMC10911275__F4 FlyBase Pathway Report pages CBL EGFR RHO PMC11667160__F6 The common upstream signaling pathways of autophagy and apoptosis under ERS BAX ATF4 ERO1A MTOR XBP1 TRAF2 PMC11667160__F4 Schematic diagram illustrating the macroautophagy process ATG101 ATG10 ATG3 ATG12 ULK1 ATG5 PMC11667160__F5 Schematic diagram of ERS regulating autophagy through four pathways ATF4 MTOR SESN2 XBP1 TRAF2 PMC3356354__F10 High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes CBL FYN BCL10 LAT ITK CTLA4 GRB2 LCK PMC11667160__F3 ERS-induced apoptosis BAX ATF4 ERO1A TRAF2 PMC6604479__F2 Improving Outcome in Infantile Autism with Folate Receptor Autoimmunity and Nutritional Derangements: A Self-Controlled Trial TH RFC1 TPH2 PMC1913583__F1 The methionine and folic acid cycles and the metabolic pathway of arsenic AS3MT HEL-S-21 PMC3963078__F7 HIV-1 Nef Induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors EBP AKT3 PMC9356043__F9 Virus-host interaction analysis in colorectal cancer identifies core virus network signature and small molecules DDX3Y DEK CDK2 DDX3X PMC8006014__F1 Insulin signaling pathways CBL GIP PMC8006014__F2 Pathological effect and consequence of insulin resistance BAD PDE3B INSR FOXO1 PTEN GRB2 PMC9259869__F1 Gestational Diabetes Mellitus and Energy-Dense Diet: What Is the Role of the Insulin/IGF Axis? IGF1 IGFBP1 IGFBP2 IGF1R IRS1 PMC2798710__F1 New roles for Notch in tuberous sclerosis STAT3 TSC2 TSC1 MTOR NOTCH1 PMC7755949__F3 Ubiquitin System and A20: Implications in Health and Disease MAP3K7IP1 TRADD BCL10 TAB3 TRAF6 CYLD TRAF2 PMC7715027__F2 Transcription regulation and consequent tissue functions in hypercapnia CXCL12 DPT BCL2 ARHA REL TNF CXCL14 PMC11784343__F6 The figure shows the PI-PLC protein, which participates in the IP3 and IP4 synthesis pathways and mobilizes calcium to regulate cell reactions and proliferation requiring free calcium RUTBC1 TWIST1 CTNNB1 PMC5772763__F1 Aneuploid cell survival relies upon sphingolipid homeostasis UGCG SGMS1 SGMS2 PMC8814915__F1 A9-Containing Nicotinic Receptors in Cancer STAT3 BAX CHRNA9 PPM1F TWIST1 PMC7287924__F1 Model Schematic SRC CD47 CIT PMC5125867__F2 T cells in Systemic Lupus Erythematosus CD44 STAT3 ICOS SYK IRF4 MTOR BCL6 PMC6170398__F2 Central role of hepcidin in regulation of iron metabolism ERFE STAT3 IL6 PMC7824065__F6 Metabolic reprogramming to form metastatic tumors ACSS2 PHGDH ASNS PRODH PMC2922222__F1 Conserved ATR→CHK1 checkpoint signaling pathway in eukaryotes (, ) TOPBP1 ATR ATRIP PMC2517145__F1 PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells PTEN RHO CCND1 IRS1 EIF4E PMC5464836__F9 Combinatorial treatment with polyI:C and anti-IL6 enhances apoptosis and suppresses metastasis of lung cancer cells STAT3 TLR3 PMC5684649__F1 Proposed salinity tolerance mechanism in Cicer arietinum L CAP2 SOS1 CARF SOS2 PMC8317254__F1 Mitochondrial and Organellar Crosstalk in Parkinson’s Disease LRRK2 MFN1 MFN2 BCL2 PMC9600485__F1 TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems BAX APAF1 FADD PMC5955615__F1 Inhibition of the dysregulated NF-kB/YY1/Snail loop CDH2 YY1 PMC5904225__F10 Schematic summary of the findings IL6 CCL2 CXCL8 IL1B PMC7933493__F1 Retinoid cycle of retina RPE LRAT RPE65 PMC8961787__F1 Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension ACAT1 ACSL1 HEL-S-133P CD36 ACAT2 SLC7A5 ACACA PMC9185072__F3 Increased serum concentrations of estrogen-induced growth factors Midkine and FGF2 in NF1 patients with plexiform neurofibroma TF NF1 ERG FGF2 PMC6454881__F6 NAD+ regulates T-cell differentiation through a novel MC-dependent signaling pathway TG FOXP3 GATA3 PMC5368067__F1 Wnt signaling pathway and targets of small‐molecule inhibitors BCL9 TMEM88 DKK1 APC LRP5 LRP6 CTNNB1 PMC10318600__F1 Signaling pathway of ferroptosis GPX4 HEL-75 PMC9044760__F2 RIPK3-mediated necroptotic pathway FAS TRADD MLKL TRAF2 FADD PMC7261776__F8 Abnormal expression of bHLH3 disrupts a flavonoid homeostasis network, causing differences in pigment composition among mulberry fruits MYB GLS CS PMC5004891__F4 STING: infection, inflammation and cancer CGAS CD8A IL1B MYD88 PMC7071808__F2 Oxidative stress in TGFB1-mediated fibrosis SMAD2 TRAF6 PMC9638655__F1 Blood-based biomarkers for diagnosis, prognosis, and severity prediction of COVID-19: Opportunities and challenges MADCAM1 TLR3 VCAM1 TNF ACE2 PMC11277296__F2 Mechanisms of mitochondrial dysfunction HTRA2 BAX TBK1 CGAS FIS1 TRADD OPA1 MFN1 IRF3 MFF NLRP3 MFN2 FADD PMC8468289__F1 Influencing Factors and Molecular Pathogenesis of Sarcopenia and Osteosarcopenia in Chronic Liver Disease MYOD1 SGK1 ULK1 SMAD2 ELF2 SMAD4 PTEN ARHA DEPTOR EIF4E RHEB MYOG TSC2 TSC1 PMC3857553__F2 Summary of Tim-3 expression on different innate immune cell populations and its functions TLR3 C2 TLR9 TLR7 PMC3947657__F4 H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity FGF13 NTS PKIB KCND2 CD36 ZNF300 ADARB1 ACE2 NOX4 DCN PMC8959827__F8 PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis CTRL PDK4 HMGCR PDC PMC3794709__F1 Steps in the reverse cholesterol transport pathway LPL ABCG1 LDLR PLTP ABCA1 PMC8949885__F2 Marginal Zone B-Cell Populations and Their Regulatory Potential in the Context of HIV and Other Chronic Inflammatory Conditions CD40 CD83 BCR NR4A3 MTOR TLR10 PMC3439334__F5 WNT signalling pathway map enriched with genes up-regulated in tumorgraft-forming tumors CDC42 MMP7 LIMK2 SMAD2 GSK3B PLG VAV1 MTOR ARHA SHE RAC1 CTNNB1 EIF4E HRAS MAP3K7IP1 PAK1 NLK SRC CP PMC4338284__F4 Molecular Characterization of the Peripheral Airway Field of Cancerization in Lung Adenocarcinoma USP14 TUSC2 DAG1 B4GALT1 IFRD1 DIAPH2 AIP DUSP4 ELOVL1 MAP2K1 MAP2 FERMT2 PMC3439334__F6 Immune response pathway map enriched with genes down-regulated in the tumorgraft forming patient tumors HRAS IFNG HLA-E MAP3K1 VAV1 ATF2 SHE FOS PMC8580479__F1 Hallmark features of cellular senescence MTOR CCL2 CCL20 PMC4838829__F4 Genome-wide association studies for fatty acid metabolic traits in five divergent pig populations SCD FASN FADS2 ELOVL5 ELOVL6 PMC3337162__F2 Polarization of migrating cortical neurons by Rap1 and N-cadherin CDC42 RALB RALA VAV2 IQGAP1 RAC1 RALBP1 PMC11206589__F1 Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies BAX EGFR FASN IGF1R PMC5649128__F1 Role of Platelet-Derived Transforming Growth FactorB1 and Reactive Oxygen Species in Radiation-Induced Organ Fibrosis SMAD2 TRAF6 PMC5295401__F5 Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells RABGGTB RABGGTA FNTA PMC7015854__F2 Isolation of an archaeon at the prokaryote–eukaryote interface MAL DHDH DCN CIT PMC9956228__F2 New Insights into the Genetics and Epigenetics of Aging Plasticity EZH1 PRDM8 KDM5B ASH1L KAT6A PRDM16 KDM5A NSD2 EZH2 SIRT2 ME1 ME3 HDAC1 ME2 HDAC2 SIRT1 SIRT6 PMC9417543__F1 Microbiota and COVID-19: Long-term and complex influencing factors TMPRSS2 ARG1 IL6 FOXP3 MTOR ACE2 PMC4650145__F7 NeurimmiRs were found targeting multiple molecules of the integrin and NFKB pathway CDC42 CD40 RAB5C BTK MIB2 CREBBP HEL-S-28 NOD1 TRAF3 TRAF2 RAB21 PMC5821033__F2 TGFB/SMAD4 signaling in cancer TF SMAD2 APC SMAD4 PTEN ATF2 MTOR CTNNB1 PMC11603854__F1 Current concept of the signaling pathway underlying the Beta-adrenergic regulation of CaV1 DCT CS PMC4696840__F3 miRNAs regulate cell metabolism by targeting key metabolic enzymes and multiple oncogenic signaling pathways BAX HGF GLS HK2 EGFR PTEN TIGAR MTOR PMC4148364__F5 Pathway analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway database KEL ND6 ND4 ND3 CENPE ME1 PMC11083429__F1 When a DNA single-strand break (SSB) happens, poly (ADP-ribose) polymerase (PARP) guides SSB repair through NAD+poly(ADP-ribosyl)ation (PARylation) of histones and chromatin remodeling enzymes BARD1 FANCD2 BRD4 ATR CYP17A1 BRCA1 USP1 CHEK1 ATM PALB2 SSB PMC8061829__F1 Fungal cell wall: An underexploited target for antifungal therapies C7 HEL-S-11 PMC11206589__F2 Suggested anticancer molecular mechanisms of bromelain CD44 CDC2 BAX CDK2 CDK4 PMC11206589__F3 Suggested anticancer molecular mechanisms of sulforaphane CD44 BAX CDK6 GCLC CDK2 PTEN CDK4 IL1B PMC3866192__F1 Polymorphisms of CYP51A1 from Cholesterol Synthesis: Associations with Birth Weight and Maternal Lipid Levels and Impact on CYP51 Protein Structure HMGCS1 CYP51A1 HMGCR ACAT2 EBP SC5D DHCR24 DHCR7 HSD17B7 LBR PMC4066667__F3 Current understanding of molecular mechanisms regulating spermatogonial stem cell (SSC) self-renewal in mice ETV5 EGF LHX1 FYN GDNF BCL6B TAF4B LYN PMC9242006__F1 Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression IDE FZD4 SPHK1 CFTR FABP4 CD8A SYT1 IL1B HEL-S-44 FGF2 PMC8216287__F4 Multi-functionality of UHRF1: epigenome maintenance and preservation of genome integrity BRCA1 ATM UHRF1 PMC5093979__F3 Genes and interaction relationship in the module 31 (a) and 35 (b) POLD3 DKK3 PCNA IRF2 AIM2 IRF1 GBP1 KIN POLD2 GBP2 PMC5979412__F3 NFKB-Mediated Inflammation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Does Autophagy Play a Role? RELA RELB MTOR PMC3852044__F3 MAPK signalling pathway MAX RAN FAS BAP1 CD14 TNF TRAF6 FLNA MEF2C MOS NLK GRB2 BDNF TRAF2 PMC3852044__F4 Wnt signalling pathway SIAH1 ROCK2 APC SKP1 ARHA NLK PMC12183292__F3 Molecular activity of platelet-regulated T cell immune response in acquired aplastic anemia (AA) TFAM IFNG CXCR3 CXCR5 PMC11979264__F7 Mechanisms by which Met inhibits HGHF-induced ferroptosis and DOP SLC3A2 FTH1 GPX4 SLC7A11 PMC12136294__F4 Profiles of DEGs and DAMs in TCA cycle, insulin signaling pathway and Glycerophospholipid metabolism in response to diapause OGDH PC CS PMC2896553__F6 DISTINCT SPECTRUM OF COPY NUMBER ABERRATIONS IN PAEDIATRIC HIGH GRADE GLIOMAS SPEN NRAS ATM PSCA PMC8959898__F1 Non-Alcoholic Fatty Liver Disease in HIV/HBV Patients – a Metabolic Imbalance Aggravated by Antiretroviral Therapy and Perpetuated by the Hepatokine/Adipokine Axis Breakdown IL10 NR1C1 TLR4 FGF21 CD14 IL6 CHAD MTOR TNF PMC4365363__F3 The major TNFR1-mediated signaling pathways CSA2 TRADD MLKL TAB3 TNF TRAF2 FADD PMC7556656__F1 NOTCH1 signaling pathway and effects of NOTCH1 mutations on CLL susceptibility to anti-CD20 mAb SPEN APC ADAM10 NOTCH1 PMC6255977__F1 Transcriptome response of Salvia miltiorrhiza to overexpression of AtPAP1 CAD CCR2 CS PMC6885903__F3 The constructed network included a main connected component and 9 isolated nodes (DEGs) SAMSN1 IFIT1 PTPRC RSAD2 IL6 IRF8 STAT1 RORC OASL MX1 ISG15 OAS1 OAS2 PMC10124776__F1 Pig heart and lung xenotransplantation: Present status GAL HLA-E APC SIRPA CD47 PMC6797571__F2 Platelet‐derived growth factors from breast cancer or neuroblastoma stimulate the platelet‐derived growth factor (PDGF) receptors and initiate immune and tumorigenesis response BAD TLR3 TLR4 TLR9 PCNP BIK PMC4287412__F9 Regulation of Wnt canonical and calcium-dependent pathway molecules in microstructured Ti surfaces SOST WNT3A DKK1 APC ROR2 DKK2 SFRP1 PMC7356262__F11 Schematic figure of the NFKB signaling pathway and inhibition of IKK complex after treatment with VA TRADD IRAK1 CCL5 TRAF6 TRAF2 IRAK4 IL1B MYD88 PMC4957332__F4 Changes in transcript abundance of genes involved in central metabolic pathways and bioprocesses in response to elevated CO2 in C-169 ASL HEL-S-162eP OTC CS PMC6851586__F1 Pathways in the pathogenesis of PSO CXCL9 STAT3 S100A7 DEFB4B CXCL5 CXCL1 KRT16 CXCL2 CXCL10 CXCL8 CXCL3 CXCL11 DEFB1 PDC HLA-C CCL20 DEFA1B IL1B PMC11873641__F1 Metabolic adaptations in cancer cells ACLY ACSS2 FAS CD36 SCD LDLR FADS2 HEL-S-26 PMC7600801__F1 MAPK signaling pathway (A) in a BRAF inhibitor-sensitive cell showing sites of action of BRAF inhibitors and MEK inhibitors, and (B) after BRAF inhibitor resistance development NF1 BRAF PTEN MDM2 MTOR PMC11873641__F4 Intricate signaling pathways linking obesity to cancer progression IGF1 IGF1R IL6 MTOR MYC PMC5627415__F2 Epigenetic mechanisms currently associated with aortic VICs BGLAP MMP16 SMAD1 MMP14 ALPL TGFBI TGFB1 MMP9 RUNX2 SPP1 CTNNB1 BMP4 BMP2 MMP2 SIRT6 PMC9444135__F1 Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance VCAM1 MTOR PMC8399842__F1 Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine STAT3 NOS2 CYP3A4 TNF PMC2975200__F9 MyD88-induced protein accumulation pathways through SQSTM1 and HDAC6 SQSTM1 TRAF6 CYLD HDAC6 MYD88 PMC3193496__F1 Two conserved branches of the canonical Wnt pathway TCF3 HIPK2 SYS1 POP1 PMC3229036__F2 Subversion of the actin cytoskeleton during viral infection CDC42 ROCK2 LIMK2 LIMK1 ROCK1 F11 ARHA SRC RAC1 PMC3193496__F2 HIPK2 and NLK/LIT-1 in Wnt signaling TCF3 HIPK2 WNT1 TCF4 WNT3 NLK POP1 PMC4610178__F4A Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise RB1 CDKN2A CDK6 CCNE1 CDKN1A E2F3 CDK2 MDM2 CCND1 CDK4 PMC9321669__F5 Dissimilative Pathway of Komagataella phaffii (Pichia pastoris): Formaldehyde Toxicity and Energy Metabolism CTRL MAL APP PMC7885873__F1 Cytokine regulated alterations to the splenic microenvironment during experimental visceral leishmaniasis CXCL12 CCL19 CXCL13 CCL21 PRDM1 CCR7 NTRK2 TNF LAG3 PMC7675396__F4 Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation TF TFPI TNF ACE2 IL1B PMC5325762__F4 The DNA Damage Response During the Life Cycle of Human Papillomaviruses TOPBP1 ATR ATRIP RAD17 PMC6391454__F4 Graphic image representation of the possible mechanisms of lung inflammation in COPD involving purinergic signaling pathway ENTPD1 ENTPD2 ENPP1 ENTPD3 ADA PMC8508793__F2 RNA Deregulation in Amyotrophic Lateral Sclerosis: The Noncoding Perspective TBCE FUS NMI INA ATXN2 PMC5325762__F3 The DNA Damage Response During the Life Cycle of Human Papillomaviruses RAD50 MRE11A BRCA1 RNF168 ATM MDC1 PMC4304915__F6 HIV-1 Tat activates a RhoA signaling pathway to reduce NMDA-evoked calcium responses in hippocampal neurons via an actin-dependent mechanism EXOC3 ARHA SRC PMC4706528__F1 PI3K/Akt/mTOR (PAM) pathway and inhibitors of the pathway tested in phase I-III clinical trials on solid tumors and/or breast cancer TSC2 CDK6 TSC1 INPP4B PTEN MTOR CDK4 PMC4491894__F3 Differential expression of a core set of genes whose products comprise a functional interactome is an underlying feature of chronically wounded RPE cells GLDC PMCH LTBP1 MYB NTS TGFBI NCAPG LPCAT3 SPARC FHL2 NMU DNM3 TYMS FANCA INHBA GALNT12 USP1 MAF DCN SMC4 SRGN LPL FBN1 SLPI dik HAPLN1 OAS3 VEGFA EDNRA MCM6 CENPA IGFBP7 PLCB4 TGFB1 MAPK11 PIK3R3 HMMR THBS2 CLSPN SHC2 BLM PRKCB MERTK LMO7 DNA2 CCND2 FST ADAM12 FHL1 VASN GAL THBS1 FZD7 NRP2 LPAR1 GBP1 KITLG SFRP1 SPP1 GPR68 PCSK7 SERPINE2 PRSS1 SKA3 PMC9612213__F3 Molecular Mechanisms of Inflammasome in Ischemic Stroke Pathogenesis NLRP3 TLR4 RIPK1 FADD MYD88 PMC6300500__F1 Models for antigen cross-presentation mechanisms induced by adjuvants in DCs SNAP23 RAB34 TLR4 MYD88 PMC33333__F2 Role of the antioxidant response element and the transcription factor Nrf2 in chemoprevention KEAP1 MAF NRF1 PMC7332907__F2 Roles of FFA2 in immune cell populations STAT3 NLRP3 ELL ALDH1A2 IRF4 XBP1 PMC3221684__F8 Insulin Receptor-Mediated Signaling via Phospholipase CG Regulates Growth and Differentiation in Drosophila STAR EGFR RHO SHE PMC4009148__F2 Signaling pathways induced by IL-17F IL17RC RAF1 TRAF6 PMC9532630__F1 Cellular loci involved in the development of brain arteriovenous malformations BMP10 ENG BRAF KRAS PMC3783562__F3 Metabolic actions of Rho-kinase in periphery and brain STAT3 FOXO1 ROCK1 POMC NPY SOCS3 AgRP MTOR PMC6812177__F1 Proposed mechanisms of inflammasome involvement in RTT OxInflammation.The scheme summarizes the basal and LPS + ATP-stimulated status of the inflammasome pathway by comparing the responses of CTR and RTT fibroblasts NLRP3 IL1B PMC7738752__F1 Omega 3 and Omega 6 metabolic pathway (from ) FADS2 FADS1 ADA PMC5397677__F1 Signaling pathways relevant to glial neoplasms in adults and children PIK3CA MYB RAF1 EGFR BRAF PTEN TERT KRAS CDKN2A NF1 PDGFRA FGFR1 HEL-S-26 MGMT MYBL1 PMC10038327__F3 Mitochondria as disease-relevant organelles in rheumatoid arthritis SLC5A12 IL18 TNF IL1B PMC140665__F8 Interaction between the Wnt/Beta-catenin and Wnt/Ca2+ pathways WNT1 NLK CTNNB1 PMC10038327__F4 Mitochondria as disease-relevant organelles in rheumatoid arthritis SLC16A3 GLUD1 STAT3 CCL18 HEL-S-62p RFX5 PMC7591300__F1 Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19? TMPRSS2 FURIN ACE2 PMC11745087__F3 Newly elucidated regulatory mechanisms relevant to RNA m6A modification (created in Figdraw) IGF2BP3 SOX2 KHSRP MTOR SLC7A5 PARP1 CTCF SETD1A PSMD9 KPG_010 METTL3 IGF2BP2 TBP PMC3193496__F4 Context-dependent function of HIPK2 in Wnt signaling TCF3 HIPK2 LEF1 PMC11745087__F2 Outline of the interplay between m6A modification and radiation-induced injury effects on distinct normal organ tissues (created in Figdraw) HMGB1 TIRAP FOXO1 ERRFI1 ALKBH5 METTL14 YTHDF2 METTL3 IGF2BP2 PMC7488244__F1 Melatonin and urological cancers: a new therapeutic approach SIRT1 FADD PMC3458271__F2 Two proposed models of ephrin-B reverse signaling in palatal EMT based on current evidence STAT3 MTOR PMC11881903__F7 Proposed model depicting the process underlying TOD-dependent muscle regeneration CCL3 CCL2 PARP1 PMC11931045__F2 Red rectangles for upregulation, the blue rectangle for downregulation MTOR PMC12024679__F2 Notch1 pathway FBXW7 HES4 DTX1 MYC NOTCH1 PMC3712714__F1 Interaction between the vitamin D endocrine system and the inflammatory signaling pathway in control of cancer cell growth (for details, see ) NR1i1 CYP27B1 CYP24A1 PMC5504949__F2 IL-6/soluble IL-6 receptor signaling at the nexus of endocrine function: illustrative examples TH STAT3 STAT1 TJP1 STC1 PMC5665664__F6 Regulatory model of ATX expression in adipose tissue and the biological functions of adipocyte-derived ATX in diet-induced obesity LPA STAT3 LIF PMC9415106__F4 Application of Mesoporous Silica Nanoparticles in Cancer Therapy and Delivery of Repurposed Anthelmintics for Cancer Therapy STAT3 EGFR MTOR YAP1 CDK4 CTNNB1 PMC5350572__F8 Illustration shows the proposed overall mechanism by which butyrate inhibited proliferation and induced apoptosis in hepatic cells PTEN SIRT1 CTNNB1 PMC9452304__F1 Complete biosynthetic pathway for the production of vinblastine in yeast IPP ADH6 IDI1 PMC9495847__F10 Paeonol Attenuates Hepatic Ischemia/Reperfusion Injury by Modulating the Nrf2/HO-1 and TLR4/MYD88/NFKB Signaling Pathways BAX KEAP1 TLR4 MYD88 PMC6391560__F6 Model for light input to the circadian clock network of Drosophila PDF ECEL1 SLN PMC8458276__F6 Different MMR excision-resynthesis pathways PCNA POLE PMC6532024__F6 Regulatory mechanisms of the IL-17–TRAF6 pathway USP25 TBK1 EBP TAB3 TRAF3 TRAF6 PELI1 TRAF4 CARD14 MAP3K7IP1 BCL10 TRAF5 TRAF2 CYLD PMC11943269__F4 Schematic model represents the possible RT role in adjuvant therapy for TNBC STAT3 CXCR6 EGFR PTGR1 TTK MTOR DHODH PMC8017943__F4 GA biosynthesis and isoprenoid pathway mRNAs in SRB suspensor and embryo proper regions PMC3285038__F1 Schematic of Smads mediated TGFB signaling pathway SMAD2 SMAD4 TGFBR1 PMC6532024__F2 Receptor signaling pathways upstream of TRAF6 ECSIT CD40 CARD14 RIPK2 RIGI MAVS BCL10 TBCEL CARD11 NOD2 IRAK1 TRAF6 PMC3285038__F2 Schematic summarizing the role of signaling Smads in epithelial carcinogenesis HGF SMAD2 SMAD4 PTEN PMC6532024__F3 Inflammatory loops in the EIME of psoriasis SAA1 CARD14 IL24 BCL10 CXCL1 CXCL2 TRAF6 CCL20 PMC6886017__F6 Diagrammatic representations of putative mechanisms of microRNA 375 in regulating metadherin-induced cell proliferation, cell migration, and angiogenesis in human colorectal cancer MTDH PI3 NFKB1 RELA NFKBIA BRAF VEGFA KRAS CTNNB1 PMC9532630__F4 Cellular loci involved in the development of brain arteriovenous malformations COX2 TLR4 IRAK1 MYD88 PMC9294167__F1 Multifaceted Role of STAT3 in NK-Cell Tumor Surveillance STAT3 SOCS3 JAK1 TYK2 PMC6136085__F2 Persistent infections through defective viral genome immunostimulation MAVS TRAF1 TNF PMC4294505__F9 CCR7-stimulated phosphorylation-inhibition of AMPK CCL19 CCL21 CCR7 PMC5825917__F3 Means to enhance the immune response in the tumor microenvironment (TME) IFNG HGF FAP PMC12127168__F4 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways BAX BAD JAK1 CCND1 GAB2 PMC12127168__F5 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways HHIP SUFU PTCH1 SHH SMO PMC8049868__F1 Recognized pathways of androgen biosynthesis in prostate cancer STAR CYP17A1 CYP11A1 AKR1C2 PMC12127168__F2 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways TRAF6 TRAF2 MYD88 PMC4023177__F3 Key signaling pathways involved in the early recurrence/metastasis (R/M≤6months) and late recurrence/metastasis (R/M6-12months) of H-HCC STAT3 SPDEF GHRL SMPD2 CTSC MAOA RB1 IFNG HEL-S-99n POSTN ANGPT1 PRKCA F2RL1 TOMM40 SRC GLB1 CEBPE HNRNPAB CD209 APOC3 OPA1 SREBF2 PRTN3 HEL-S-78p CYFIP1 FGA HNF1A PPL DIABLO NUPR1 MPO PLAA FXR1 PIG59 CLU CASP4 ALDH3A1 CEBPD HSF1 DPP4 LDLR SOAT1 MUC1 APP GPLD1 KNG1 CRP ACHE BAX NR1H3 IL13 FASN OSCAR SSB APOA2 MBL2 ITGAM IPO5 PDGFRA RELA LGALS4 KANK2 SNX33 CORO1A SNX2 TNFSF10 ApoL6 TIMM23B PMC12127168__F3 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways APC ZNRF3 CTNNB1 PMC12127168__F8 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways KEAP1 NQO1 MAF PMC4327859__F1 TLR4/NFKB signalling pathway and TLR4/ MAPK signalling pathway in gastrointestinal epithelium MAP3K7IP1 TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC9469633__F8 Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer WNT7A MTOR CTNNB1 PMC12127168__F6 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways STAT2 GRB2 JAK1 TYK2 PMC4968087__F7 ACTIVATION OF p53 IN DOWN SYNDROME AND IN THE Ts65Dn MOUSE BRAIN IS ASSOCIATED WITH A PRO-APOPTOTIC PHENOTYPE BAX MDM2 SIRT2 SIRT1 PARP1 PMC3902845__F2 Multiple changes in gene expression influence KRAS activity, the KRAS downstream pathway and cell growth occur during development of a “mature” PDAC cell EGF TGFA EGFR PMC3969038__F1 NFKB signaling pathway and cancer related mutations BCL10 CARD11 RELA MYD88 PMC2064840__F9 Divergent TGFB signaling pathways induce transcriptional regulation through Smads and translational regulation through the mTORC1 pathway SMAD2 SMAD4 PMC12019327__F7 Mechanism of anticancer action of salinomycin and oxaliplatin cotreatment against CRC cells BAX CASP9 CASP3 PMC5462861__F1 Nrf2 activation by misfolded proteins KEAP1 PMC12021879__F1 Mechanistic map of metabolic bone disease: The pathogenesis of MBD primarily involves four key pathological dimensions: abnormal bone resorption, abnormal bone formation, abnormal mineral deposition, and metabolic factors SMAD1 DKFZp781O1323 LRP5 LRP6 NFATC1 PTH FGF23 PMC10451275__F3 Changes in subcellular localization of Ras upon S-nitrosylation HRAS HIF1A SRC PMC5400663__F1 Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas EGF SMAD1 DKFZp781O1323 EGFR MTOR PMC7699726__F2 KEAP1-NRF2 modulation in cancers such as RCCs CSA2 FH KEAP1 BRAF MTOR MYC KRAS VHL TSC2 TSC1 FYN PRCC SIRT1 PMC2902148__F2 Inhibition of VEGF signaling pathways VEGFB VEGFC VEGFA PMC2902148__F1 VEGF signaling interactions VEGFB VEGFC PIGF NRP1 NRP2 VEGFA PMC4255606__F4 Proposed role of stem-progenitor cells in leiomyoma pathogenesis MED12 HMGA2 CTNNB1 PMC8463536__F3 P53 family members, such as p53, p63, and p73, some transcription factors, such as SP1 and CREB, and noncoding miRNAs, such as miR-144, miR-885-5p, and miR-101 regulate the transcription of TIGAR SP1 NSD2 HIF1A TIGAR MYC PMC3422654__F1 Genes Associated with Outcomes in the Context of Two Fatty Acid Metabolism Pathways MLYCD ACSL1 ACSL3 AGPAT3 PMC8463536__F4 Enzymatic activity of TIGAR TIGAR PMC9220138__F4 Nrf2 Activation in Chronic Kidney Disease: Promises and Pitfalls ACLY TFAM CD36 FASN SLC25A1 NF2 CPT2 PMC5984538__F4 NFKB and Wnt signaling pathways LTA TRADD APC TAB3 GSK3B LRP5 LRP6 BBC3 TRAF3 TNF AXIN2 CTNNB1 NGF MAP3K7IP1 MAP2K6 TRAF5 ATM NLK TRAF2 IL1B BIRC3 PMC5864212__F6 Deciphering the nature of the coral–Chromera association EEA1 CD63 PMC10453069__F4 DNA repair pathways of DNA double-strand breaks TOPBP1 ATR RAD50 RAD51 WRN BRCA2 NBN FANCA BLM FANCC RBBP8 PARP1 FANCD2 FANCF MRE11A BRCA1 ATM PALB2 PMC6925091__F5 Necroptosis is an example of antagonistic pleiotropy RIPK3 ZBP1 MLKL RIPK1 MTOR PMC6558469__F1 Mechanisms of tumor progression and tumor microenvironment‐mediated immune evasion in classic Hodgkin lymphoma (cHL) CD40 CD163 PMC10453069__F2 ATM- and ATR-mediated pathways in the presence of damaged DNA TP73 CDC2 TOPBP1 ATR H2AX WEE1 ATM PMC10453069__F3 Excision repair pathways of DNA single-strand breaks ERCC1 MSH6 MSH2 MSH3 PMS2 PCNA XPC OGG1 MLH3 LIG1 APEX1 AGA APEX2 PMC8122702__F2 NRF2/KEAP1 Signaling Pathway in Cancer Metabolism RBX1 KEAP1 PMC10453069__F1 Clonal evolution of plasma cell dyscrasias BRAF ATM MYC KRAS PMC9189267__F3 Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19 IL1R1 HMGB1 GSDMD MAVS NLRP3 AIM2 PMC4763179__F1 Living biointerfaces based on non-pathogenic bacteria support stem cell differentiation BMPR2 SMAD1 DKFZp781O1323 USP45 BMP2 SMAD4 PMC3379801__F8 p16-Cdk4-Rb signaling pathway diagram CDKN2A CDK6 CDKN2B CDK4 PMC6220384__F1 HMBG1 and inflammatory and immune processes STAT3 CXCL12 HMGB1 TLR4 CXCR4 PMC4012967__F1 IL-6/JAK/STAT pathway STAT3 EGF EGFR SOCS3 SRC CCND1 IL6R RET PMC4294374__F1 Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat PCSK9 TG IGF1 LDLR LRP6 MTOR PMC6220384__F2 HMGB1 and Fas/FasL signal pathway in uveitis HMGB1 FAS VCAM1 PMC2731131__F10 Schematic summary of LPS-triggered programmed cell death in human endothelial cells TLR4 FADD MYD88 PMC4285107__F1 New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish SHH PMC4107064__F1 Progress in Central Nervous System Lymphomas STAT3 CXCL12 IL10 CXCL13 PIM1 IL4 IRAK1 MYC IRAK4 MYD88 BTK BCR TLR4 BCL2 JAK1 PMC8518013__F7 Hedgehog/GLI1 signaling pathway regulates the resistance to cisplatin in human osteosarcoma SMO PMC6530347__F2 Overview of thyroid hormone (TH) production, transport, activity and regulation DIO1 NR1A2 THRA PMC11380518__F3 Biosynthesis of the IPP and DMAPP via the MVA pathway (purple) and MEP pathway (green) IPP MVD MVK PMC8642962__F6 Novel mutation of SATB2 inhibits odontogenesis of human dental pulp stem cells through Wnt/Beta-catenin signaling pathway DKK1 CTNNB1 PMC3959773__F1 Mitochondrial respiratory chain ETFDH PDSS1 COQ3 COQ2 COQ9 COQ6 CPT2 PMC12193433__F4 IL-6/JAK/STAT3 signaling pathway and oleocanthal-mediated inhibition STAT3 MMP2 JAK1 CCND1 PMC2624576__F1 Alternative splicing in the NFKB signaling pathway MAP3K7IP1 TRADD TIRAP IRAK1 IRAK2 TRAF6 TNF CYLD TRAF2 IRAK4 MYD88 PMC12193433__F3 Schematic on HGF/C-Met signaling in mesenchymal cells, activating RAS-ERK, RAC1-JNK, PI3K-AKT, and STAT3 pathways to regulate cellular processes STAT3 HGF GRB2 MTOR SHE RAC1 PMC5946030__F2 Mitochondrial DNA mediates pro-inflammatory response TBK1 CGAS TLR9 IRF3 DNASE2 TNF MYD88 PMC2999098__F3 CKI members in canonical Wnt signaling TCF3 JUN APC FOS PMC2765788__F6 STRIATAL NEUROPROTECTION WITH METHYLENE BLUE STH MB CP PMC4327859__F4 Post-transcriptional gene suppression mediated by miRNAs is involved in the fine-tuning of epithelial anti-Cryptosporidium defence SNAP23 TLR4 CX3CL1 PMC4041145__F1 Akt and NFKB signaling in drug resistance mechanism of tumor cells BAD COX2 MDM2 PMC7105577__F2 Crosstalk between major signaling pathways during nephron progenitor cell (NPC) differentiation LATS1 FAT4 LATS2 ALK DKK1 APC GSK3B GRB2 AXIN2 SFRP1 CTNNB1 PMC6854009__F4 Highlighted NF-Kappa B Signaling KEGG Pathway (hsa04040) with Enriched Genes from the LRT Analysis (Bonferroni-adjusted p < 0.05) for Influenza Infected Subjects (–) CNTF EGF NGF BCR ELL TNF EDAR CYLD DAO PMC8466445__F1 Anti-Viral Pattern Recognition Receptors as Therapeutic Targets TBK1 CGAS MAVS TLR9 IRAK1 IRF3 IRAK2 IRF7 TRAF3 TNF TRAF6 BTK TLR3 TLR8 KL TLR7 MB PMC3413411__F1 PI3K-AKT-mTOR signaling pathway RHEB MLST8 TSC1 SGK1 PI3 PTEN MTOR DEPTOR IRS1 PMC6854009__F5 Highlighted NF-Kappa B Signaling KEGG Pathway (hsa04040) with Enriched Genes from the LRT Analysis (Bonferroni-adjusted p < 0.05) for Influenza Vaccinated Subjects (–) CNTF EGF NGF BCR ELL PC TNF EDAR CYLD DAO PMC7642822__F8 Regulator effect networks generated by Ingenuity Pathway Analysis (IPA) in MCF7 over-expressed mitochondrial fission factor (MFF) BAX SVIL ROCK2 PXN PARVA FASN CD14 TYMS CCNA2 ARHA RPA1 KRT19 RB1 ADD1 ITGB1 CLU NFKBIA MUC1 MAP2K1 CCND1 PMC3652384__F2 The mechanism of late PC STAT3 STAT1 JAK1 SRC LCK PMC11852910__F4 Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies MAVS SOX9 BRD7 AMOT AXIN1 PTEN PARP1 PMC7160658__F1 Checkpoint inhibition‐induced adverse events CD80 APC PMC11852910__F5 Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies TNKS2 RNF146 HIF1A PARP1 PMC5657403__F1 Regulation of the intrinsic pathway to apoptosis by B‐cell‐lymphoma‐2 (BCL2) family members BAX BAD MCL1 BCL2 BMF HRK BIK PMC5344425__F1 Nonalcoholic steatohepatitis-related hepatocellular carcinoma: is there a role for the androgen receptor pathway? F2 GSK3B TNF CTNNB1 PMC4075482__F5 Pathway Analysis DLAT OGDH HEL-S-87p NNT NDUFA5 PMC2655983__F3 Simplified version of colorectal-cancer biological pathway in KEGG database for genes with mutation data in COSMIC PI3 APC BRAF SMAD4 KRAS CTNNB1 PMC7726150__F6 How Lrp6-APEX2 may interact with the ESCRT machinery and TFG in multivesicular body formation during Wnt-induced endocytosis TFG LRP6 PEX2 APEX2 PMC4563120__F5 The acute phase response is not generally up regulated in patients with < 14 mo survival ECSIT TF STAT3 JUN TRADD HAMP MTOR TNF FOS FGA HRK TRAF2 CP PMC7400809__F4 Action of TET inhibitors STAT3 SP1 TET1 MEIS1 PMC10741130__F6 Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer CASP9 TSC2 BAD HGF TSC1 MDM2 CCND1 EIF4E PMC7866084__F1 NLRP3 inflammasome activation in AD and PD with potential intervention of natural extractions FYN NLRP3 CD36 TLR4 MYD88 PMC8456397__F2 Molecular Insights into the Crosstalk Between Immune Inflammation Nexus and SARS-CoV-2 Virus TLR3 STAT2 IRF9 IRF3 TYK2 PMC8891531__F1 Trained Immunity: An Overview and the Impact on COVID-19 TLR4 NOD2 ATF7 MTOR TNF IL1B PMC3705551__F2 Major catabolic and anabolic pathways in mammalian cells HEL-S-133P MAL SLC5A1 CS CIT PMC11242417__F3 Signaling pathways of macrophage polarization SOCS1 STAT3 JAK3 ARG1 SOCS3 TRAF6 IRAK4 STAT1 TLR4 STAT4 JAK1 TYK2 NOTCH1 PMC9553197__F2 Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective BAX CASP9 FAS EGFR CASP3 MMP2 PTEN MMP9 MTOR RAC1 PMC11242417__F1 Macrophage origins and biological functions BCR ARG1 TNF PMC8222483__F2 Linkage between inflammation and fibrosis in muscular dystrophies: The axis autotaxin–lysophosphatidic acid as a new therapeutic target? LPA SMAD2 TGFBR3 SMAD4 RHO SRC PMC5700507__F2 Immediate immune responses of pulmonary resident cells to RSV infection in neonates TSLP CXCL1 PDC IL33 PMC7785737__F3 Wnt signaling pathways CDC2 APC GSK3B LRP6 CTNNB1 PMC3193874__F2 Caloric Restriction and Chronic Inflammatory Diseases PTEN IGF1R IRS1 PMC6916499__F1 Retinoid transport and transformations in vision LRAT RPE65 RDH5 PMC7856191__F8 Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways. SLAMF7 BCR C2 CD22 SHE PMC6434111__F1 l-Arginine de novo synthesis pathways OTC CIT PMC3103318__F7 Model pathway for genistein-induced ASAH1 transcription in MCF-7 cells ABCC1 SP1 ABCG2 PMC3693188__F1 TP53-centered network in CLL: A novel pathogenetic model for chronic lymphocytic leukemia (CLL) showing a pathway of microRNAs and cytogenics that are involved in the development of CLL ZAP70 MCL1 BCL2 ATM MDM2 PMC3484676__F3 Rbf1 occupies multiple nodes in conserved signaling pathways RHEB SPEN WBP2 TSC2 TSC1 NEDD4 PARL MIB1 SIK2 APP PTEN FURIN PMC2253531__F5 Induction of immune response to Wolbachia infection in S2 cells TUB REL FADD MYD88 PMC4751644__F1 PI3K signaling and common mutations related with ASD and schizophrenia RHEB ERBB4 NF1 PTEN BDNF DEPTOR FMR1 EIF4E PMC1622889__F1 Anti-apoptosis of families of HSPs BAX BCL2 BOK PMC8799861__F6 CGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy PDE3B CGAS TLR3 TLR4 IRF3 PMC5983771__F1 Intracellular immune ecosystem in a virus infected cell STAT1 MAVS TLR3 STAT2 TLR4 IRF9 TLR9 TLR8 TLR5 IRF3 TLR7 MYD88 PMC8799861__F5 CGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy LATS1 TF LATS2 CGAS GSDMD IRF3 PMC11655944__F2 Antitumor effects mechanism of EH STAT3 BAX TLR4 MMP2 ATF4 MMP9 MYC TNF XBP1 CCND1 IL1B PMC11655944__F3 Main components of EH Antitumor’s effects mechanism STAT3 BAX CDK6 EGFR SMAD2 SMAD4 CDK2 MTOR PLK1 PMC4771656__F7 Signaling pathway of SFN in U251MG cells BAX BAD BCL2 SFN PMC9563115__F1 Tumor-Associated Neutrophils in Colorectal Cancer Development, Progression and Immunotherapy STAT3 HGF TLR4 MSC IRS1 PMC3139800__F1 Regulation of endonuclease activity in human nucleotide excision repair XPA PCNA POLK XPC PMC10954797__F2 Graphical representation of stress signal-mediated dysregulation of p53 expression during progression from colitis to cancer ATR ATM PMC7873640__F1 Detail description of both canonical and noncanonical TGFB signaling and interaction of natural compounds in the regulation of this signaling cascade at various levels TF SMAD2 GRB2 MTOR PMC3918130__F5 Adenovirus elicits IFNAB production by a novel viral induction pathway TLR3 TLR9 IRF3 IRF7 TLR7 MYD88 PMC11966486__F1 CD28 signaling motifs mediate co-stimulatory signaling to regulate T cell function CD80 APC IL2 ITK VAV1 GRB2 LCK PMC5836070__F2 Ethanol indirectly interferes with DNA integrity by affecting key points (labeled in red) or enzymes in folate metabolism DHFR HEL-S-61p MTR PMC6867841__F7 Schematic picture depicting the effect of the immune factors on cysticercal brain infection IL18 TRAF1 TRAF3 TRAF2 PMC10954797__F4 ERCC4 may serve as an important regulatory factor for the upregulation of PD-L1 expression induced by DNA damage signals and DDR defects ATR ATM PMC7457324__F3 Metacore analysis reveals the top scored network of IL-6 pathway HEL-S-92n STAT3 APOH SAA2 A2M HP JAK1 PMC6606335__F5 Phase I/II Trial of Carfilzomib, Pegylated Liposomal Doxorubicin, and Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma BAD OMP HRK PMC7027163__F1 MAPK cascades SP1 APP PMC4599573__F8 PLB regulates remodeling of epithelial adherens junctions pathway in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis RAN HGF APC PMC9158441__F5 Aconiti Lateralis Radix Praeparata as Potential Anticancer Herb: Bioactive Compounds and Molecular Mechanisms BAX MAP3K7IP1 ATG3 MEI1 CDK2 ATF4 XBP1 APAF1 FADD PMC4580090__F1 Role of STAT3 in lung cancer STAT3 EGFR IL6 SRC PMC2953497__F9 Tumor Necrosis FactorA Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells ANKRD29 TULP2 TPT1 AP1S3 SIK1 CES2 SNCB XPNPEP2 GPX3 IL6 CTLA4 SAP30 IFITM3 ABCG2 NLGN3 TWEAK ACP5 PMC6110912__F2 Summary of roles of different DUBs on the development of cardiac hypertrophy USP14 USP4 USP18 CYLD PMC3547902__F2 Autocrine functions of VEGF in breast tumor cells ASB1 SEMA3A NRP1 NRP2 PMC4599573__F5 PLB regulates death receptor signaling in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis FAS TRADD LIMK1 GAS2 DFFB TNF ARHGDIB CASP6 ROCK1 DFFA APAF1 TRAF2 DIABLO LMNA FADD PMC6110912__F1 Summary of roles of different E3 ligases on the development of cardiac hypertrophy TCAP TRIM32 FOXO1 TRAF3 MDM2 MTOR TRAF6 TRAF2 PMC4899619__F1 TGFB/Smad canonical signaling pathway BMPR2 BMP2 SMAD4 ACRV1 PMC4599573__F2 PLB regulates cell cycle at G2/M checkpoint in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis MDM4 AURKA CDC26 CDK7 C13orf34 BRCA1 CKS2 ATM RPRM PMC10704547__F2 AhR ligand-activated pathways mediate pro-cancer activities in breast cancer cells EBP KYNU RELB PTEN MMP9 CYP1B1 CYP1A1 CTNNB1 TDO2 STAT5B MMP2 AHR PAH SAMD3 CCND1 HDAC6 PMC7912808__F6 Ingenuity pathway analysis of processes related to Barrett’s transcriptome CIP2A CEBPA SPINK1 NR2A1 TLR4 RHO HNF1A BIK SMARCA4 PMC4599573__F1 Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells ELF4 ARHA RHO MTOR PMC1978064__F4 MiR-103/107 and PANKs may constitute coordinated transcription units with synergistic cellular effects concerning cellular acetyl-CoA levels and other metabolic pathway elements ACLY ACOX1 ACSL1 PDK4 PANK3 FASN LRP6 LRP11 PDPR GLS2 PISD PMC10704547__F1 AhR ligand-activated pathways mediate anticancer activities in breast cancer cells CYP1A2 BAX AHR CYP1B1 CYP1A1 SOX4 NOTCH1 CDK4 PMC7998316__F3 Simplified scheme highlighting processes in which PD-related proteins function in the endo-lysosomal pathway VPS29 VPS35 PLA2G6 PMC5605239__F6 Model for avoidance of APOBEC-induced lesions ahead of lagging strand DNA synthesis REV1 GC PMC2834757__F9 Upregulation of SOCS-3 and PIAS-3 Impairs IL-12-Mediated Interferon-Gamma Response in CD56+ T Cells in HCV-Infected Heroin Users RB1 STAT3 STAT1 STAT4 TYK2 IL12RB1 PMC2653380__F3 Schematic representation of bile acid synthesis by the classical neutral pathway BAAT HSD3B7 CYP27A1 AMACR AKR1C4 PMC10704547__F4 AhR ligand-activated pathways/genes exhibit anticancer or pro-cancer activity in breast cancer cells KLF4 BAX AIP MMP2 AHR AHRR MMP9 CXCR4 CCND1 SOX4 PMC7004529__F1 Characteristics of cellular senescence CDK6 CDK2 CDK4 PMC4302918__F3 Metabolic crosstalk between key signaling pathways in stem cells via ROS and other metabolic co-factors UCP2 FOXO3A PTEN SIRT1 PMC7004529__F2 Biological function of senescence‐associated secretory phenotype (SASP) factors in physiological and pathological conditions CXCL1 CCL5 CCL2 PMC7004529__F3 CGAS‐STING pathway in senescence‐associated secretory phenotype (SASP) regulation TBK1 CGAS IRF3 PMC7214151__F3 Interaction between Rap2‐Hippo‐Yap1 pathway and TGF‐B signaling LATS1 TGFBR2 LATS2 SMAD2 SMAD4 HTRA1 DDR2 CTNNB1 PMC7460797__F2 1,25(OH)2D3 exerts neuroprotective effects via GDNF NR1i1 GDNF GFRAL RET PMC8566155__F1 Clinical Features and Pathophysiological Mechanisms of COVID-19-associated Gastrointestinal Manifestations TMPRSS2 CCL25 IL17A MTOR PMC7243420__F2 From Beyond the Pale to the Pale Riders: The Emerging Association of Bacteria with Oral Cancer FOXO1 ZEB2 NLK PMC6217750__F4 Redox Regulation of Heme Oxygenase-2 and the Transcription Factor, Rev-Erb, Through Heme Regulatory Motifs HDAC3 HDAC1 NCOR1 ZNHIT1 GSK3B RORA PMC8220152__F3 Deubiquitinating Enzymes Orchestrate the Cancer Stem Cell-Immunosuppressive Niche Dialogue: New Perspectives and Therapeutic Potential BMI1 USP14 STAT3 USP15 USP4 NFATC2 USP22 MDM2 FOXP3 CTNNB1 PMC3651593__F1 Pathway of Fbw7-mediated degradation RBX1 UBC SKP1 PMC9342591__F1 Cast of characters TGFB1 IL18 IL6 WNT7B WNT10A CTNNB1 PMC3392150__F1 Unfolded protein response and its role in intestinal homeostasis and inflammation ATF5 ATF4 EIF2A TRAF2 UNK PMC12131435__F8 Intricate signaling interactions between cancer-associated fibroblasts (CAFs) and cancer cells, highlighting key pathways involved in tumor progression, proliferation, migration, and metastasis GFER CXCL12 FAS HGF CXCL5 EGFR SMAD2 PTEN NODAL MTOR IGF2 CD44 POSTN EREG BMP2 VCAM1 PMC6340935__F1 The hexosamine biosynthetic pathway (HBP) leads to UDP-GlcNAc formation and regulates O-GlcNAcylation OGA OGT PMC10253447__F1 Notch signaling pathway inhibition leads to intestinal differentiation ATOH1 MUC2 HES1 RBPJ PMC5289527__F6 Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility IL6 PMC2756960__F8 Effect of DLK1 and RTL1 but Not MEG3 or MEG8 on Muscle Gene Expression in Callipyge Lambs IGF1 TXNIP HEL-S-67p PTEN IGF1R MTOR IRS1 PMC4303637__F1 Metabolic reconstruction for Candidatus Iainarchaeum andersonii genome CIC MSC FES AMH PMC4899619__F2 Multiple TGFB signaling pathways ADRBK1 ARHA GRB2 MTOR SHE CDK4 PMC4899619__F3 TGFB and tumor suppression CDK6 ID2 E2F4 BMF APAF1 DIABLO CDK4 PMC4438421__F3 TLR-ligand-mediated NFKB activation TBK1 TIRAP IRF3 TRAF3 TRAF6 MYD88 PMC6814613__F8 Proposed signaling pathway of the study NINJ2 EGFR PDGFRA PMC8777033__F3 Computational Framework to Identify Metabolic Engineering Strategies for the Co-Production of Metabolites RPE PIG59 MALL MAL CIT PMC10253447__F2 Hedgehog signaling pathway in the development of intestinal metaplasia in the distal esophagus SMAD1 DKFZp781O1323 DHH SMAD4 IHH AGR2 CDX2 SOX9 PTCH2 SUFU PTCH1 BMP4 MUC2 SHH SMO FOXA2 PMC11767263__F1 Exercise alleviates sarcopenia by regulating multiple signaling pathways RHEB FNDC5 IGF1 APC MFN2 GSK3B UCP1 CTNNB1 PMC5253284__F2 The unique biochemical aspects of MET-mediated bypass signaling driven by cell surface RTK aggregates leading to de-coupling of EGFR oncogenic function from its tyrosine kinase activity (alternate signaling) STAT3 HGF EGFR PTEN MTOR PMC4778288__F5 CRHR1 alterations in CRPS patients and schematic representation of miR-34a mediated repression of CRHR1 regulating POMC expression and BMI a CRHR1 was significantly higher in poor responders than in responders POMC CRHR1 PMC6220113__F4 Illustration of lipoprotein alterations in chemotherapy recipients after 6 months LPL TG PMC6321489__F3 Scheme of the main steps for autophagy and their regulation by AMPK ATG101 ATG10 ATG3 ATG12 DEPTOR PMC3166463__F1 RIGI-like receptor pathway RIGI MAVS TANK IRF3 IRF7 TRAF3 TRAF6 PMC12131435__F2 Process of normal fibroblasts transforming into CAFs can be described as follows: a Growth Factor and cytokine stimulation SOCS1 STAT3 IGF2R EREG SMAD2 IL33 SMAD4 FAP SRC SKI YAP1 PMC7109323__F6 Inhibition of PRRSV by LPS ADAM17 TLR4 CD163 PMC3166463__F3 Innate immune signalling at the mitochondria ECSIT TLR1 NLRX1 MAVS NLRP3 IL16 TLR4 IRGM TRAF6 PMC4534527__F1 Illustration of sonic hedgehog (SHH) signaling pathway SUFU PTCH1 SHH SMO CCND1 GLI3 PMC7765927__F2 Suggested interaction model between EBV and P CXCL5 CXCL1 MMP2 MMP9 MTOR PMC12131435__F1 Various regulated cell death mechanisms—ferroptosis (1), cuproptosis (2), and necroptosis (3)—influence the tumor microenvironment (TME) by shaping immune cell populations and modulating tumor progression ASAH2 GPX4 APC PMC3913057__F3 ErbBs/EGFR(s) signaling pathways JUN RAF1 SP1 GRB2 JAK1 MYC FOS PMC8620049__F1 Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers BAX NRAS KIT PMC8620049__F2 Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers BAX SUFU PTCH1 SMO PMC3936782__F2 Neuroprotective/apoptotic intracellular cascades at baseline and as mitigated by mood stabilizers in BD BAX BAD CAD BDNF APAF1 PMC3820259__F2 Roles of lipids in the tumour microenvironment LPA FAS FASN FABP4 PMC8870715__F1 Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements EGFR PTEN MDM2 MTOR CCND1 PMC8869227__F4 Cytoplasmic and Nuclear Functions of cIAP1 CDC42 CD40 MAP3K7IP1 TRADD TLR4 TAB3 TRAF3 TRAF2 MYD88 PMC11724356__F2 NSCLC immunotherapy resistance STAT3 CDKN2A STK11 MTAP EGFR BRAF B2M MTOR KRAS LAG3 PMC8276205__F3 PD-L1 in the immune dysfunction that mediates hypoxia-induced multiple organ injury ZAP70 STAT3 PLCG1 FOXP3 MTOR PMC7662834__F7 Insulin signaling pathway RHEB TSC2 BAD TSC1 INSR INS PMC7576823__F3 Talin1 plays significant roles in cancer related pathway JUN HEL-S-28 RHO MTOR SRC CTNNB1 PMC11666973__F6 Pattern diagram of H9N2 PB1 regulation of the RIG-I signaling pathway TBK1 MAVS TRIM25 IRF3 PMC8870715__F2 Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements BAX FADD PMC8870715__F3 Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements LAMP2 SIRT3 UVRAG ATG14 MTOR PMC8573224__F5 In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment RPE HPR HEL-S-162eP MAL PTS CS TNLG7C ADA CIT PMC7364809__F2 Signaling pathway of SGK1 in oncology SP1 SGK1 JUNB RANBP1 GSK3B GATA3 CTNNB1 RHEB TSC2 FOXO1 FOXP3 MDM2 IL23R MGMT PMC6600269__F1 Survival signaling pathways related to the PI3K/Akt pathway in mouse macrophages RHEB TSC2 BAD TSC1 BCL2 PTEN PMC8573224__F4 In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment RPE HPR HEL-S-162eP MAL PTS CS TNLG7C CIT PMC5056247__F1 Mitogen-activated protein kinase (MAPK) pathway and phosphoinositide 3 kinase (PI3K) pathway with downstream effectors RHEB TSC2 BAD TSC1 PTEN MDM2 GRB2 PMC4199593__F5 De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana VWF HEL-S-62p F5 C1S F7 F11 C2 F2 F10 F3 PROS1 THBD F8 F9 PROC PMC4767459__F2 Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer RHEB EIF4B TSC1 BRAF PTEN HIF1A MTOR IRS1 EIF4E PMC4199593__F6 De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana ECSIT TBK1 TIRAP MAVS PIM1 IRAK1 IRF3 IRAK2 IRF7 MTOR TRAF3 TRAF6 IRAK4 RAC1 MYD88 STAT1 MAP3K7IP1 TLR3 TLR8 TLR7 FADD PMC4905168__F1 Noxa and cancer therapy BAX FOXO3A ATF4 HEL-117 PMC7210406__F7 Proposed pathway of kynurenine effects on BMSCs HDAC3 CXCL12 NCOR1 IDO1 AHR CXCR4 PMC4199593__F7 De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana BAX NGF CASP8 CASP6 IL3 CASP3 BCL2 ATM PTEN APAF1 CASP10 PMC9476726__F9 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer SMAD2 MTOR PMC7827270__F2 Action of Oxaliplatin: L-OHP is transported into the cell by solute carrier family 31 (copper transporter), member 1 (SLC31A1) ERCC1 HEL-S-22 ERCC2 SLC31A1 PMC9476726__F7 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer LATS1 LPA RHO PMC3894232__F3 JAK2-STAT5B pathway and osteoblast differentiation RUNX2 GHR PMC4776098__F1 Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina PPIC STAT3 MYB PIK3CA PRKD1 RAF1 HEL-S-77 RGS16 PRKCZ HIF1A MYC STAT1 HSPD1 FLT4 PRKCA NPM1 KDR GRIN1 SRC CDH2 MAPK1 TRIO VAV3 MYH10 STAT2 RPSA SNCA EZH2 MIF VEGFA PAX6 DAB1 HNRNPA2B1 FOXO1 PAK1 MCM3 PLCB2 MCM2 GRB2 AKAP12 CXCR4 RET CXCL12 HEL113 TSHR SGPL1 ITCH EGFR BRAF CCR3 OTX1 MTOR RUNX2 KHDRBS1 CTNNB1 PLCG1 TYRO3 HEL-S-2a MYH9 CHUK HDAC6 HEL-S-15 HSP90AB1 CDC2 HEL-S-101 PTN FASN ID1 VHL ID3 NR3C2 RORC FOXO3A PDGFRA RPS6KA3 MAP2K1 MAP2K2 HEL-S-87p DDX3X PMC9476726__F5 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer STAT2 COX2 EPOR EPO GRB2 MTOR TYK2 PMC4776098__F2 Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina STAT3 RAF1 SHC1 RGS16 HIF1A CCL5 MYC MAPK3 FYN STAT5B NPM1 HTT CDH2 MAPK1 AXL RPSA MIF IRS1 YAP1 PRKCI HNRNPA2B1 PAK1 CDKN1B CSK EN1 BCL2 CXCR4 CXCL12 HEL113 MMP14 EGFR SPHK1 CCR3 MTOR ITGAV CTNNB1 ROCK1 CHUK CCND1 HDAC6 FASN HEL-S-89n VHL FTH1 FOXO3A IKBKB CCR4 HEL-S-87p DDX3X PMC9476726__F6 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer HHIP SUFU PTCH1 SHH SMO PMC9476726__F3 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer EGF BAD EGFR PTEN PDK2 MTOR PMC9476726__F4 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer APC GSK3B ZNRF3 CTNNB1 PMC3587995__F2 p53/p21/pRb/E2F and p16/pRb/E2F signaling pathway BMI1 MDM2 CDK4 PMC9476726__F2 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer ECSIT TRADD COX2 TNF TRAF2 FADD MYD88 PMC3894232__F2 JAK2-STAT5B pathway and osteoblast differentiation IGF1 STAT5B GHR PMC4824608__F1 Various possible mechanisms of Ca2+-ITPR-mediated control of autophagy MCOLN1 ULK1 TFEB BCL2 MTOR ULK2 PMC9008778__F4 Thrombosis and Inflammation—A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C TF VWF NLRP3 IL18 PC PF4 PMC9008778__F5 Thrombosis and Inflammation—A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C TSC2 TSC1 NLRP3 APC PC PARP1 IL1B PMC4377021__F10 Relevant crosstalk of altered signaling pathways involved in cell death for PTC and ATC S100A4 TIMP1 S100A10 ANXA2 PIAS1 NRP2 GATA6 PMC8934861__F5 Analysis of Gene Expression Profiles in the Liver of Rats With Intrauterine Growth Retardation LPL UBC AQP7 FABP1 FABP2 UCP1 HEL-S-28 FABP4 PLTP PMC4606863__F1 Eicosanoid Storm in Infection and Inflammation LTB TRPA1 COX1 COX2 LTC4S TRPV1 PMC9124149__F1 Mitochondrial Malfunction in Alzheimer's Disease: New Therapeutic Hope FIS1 MFN1 MFN2 MIF PMC4459756__F3 Risk loci of human autoimmune diseases associated with the TFH developmental pathway TH STAT3 ICOS CD80 PTPN22 BATF IL12A CXCR5 STAT4 IRF8 IL23R IL12B PMC4606863__F3 Eicosanoid Storm in Infection and Inflammation NLRP3 COX2 TLR4 IL1B PMC3420349__F1 P53 signaling pathway: In normal conditions (black arrows), p53 is maintained at very low levels BAX ATR PCNA ATM MDM2 PMC8117096__F3 CGAS-STING Pathway: Novel Perspectives in Liver Diseases TBK1 CGAS IRF3 PMC5412459__F1 Isotopomer formation through carbon distribution of [1,2-13C2]-glucose HEL107 MAL PC CIT PMC5296735__F5 Integrated Analysis of LncRNA-mRNA Co-Expression Profiles in Patients with Moyamoya Disease CSF3R CSF2RA CXCR1 CXCL16 IL8RB BCL6 FOS PMC7661711__F2 PTRH2: an adhesion regulated molecular switch at the nexus of life, death, and differentiation RPS6 BAX PKD1 PTRH2 BCL2 MTOR PMC6584781__F1 Signaling pathways that converge on p38 mitogen-activated protein kinase (MAPK) activation and formation of plexiform-like lesions in pulmonary arterial hypertension (PAH) STAT3 TG VEGFC TSN MMP9 PMC7816286__F6 Potential signaling pathway by which CD90 regulates biological behavior and energy metabolism in gastric cancer cells SIRT3 PTEN MDM2 SIRT2 SIRT1 SIRT6 PMC7186402__F1 Classic control network of ferroptosis SLC3A2 GCLM LPCAT3 FACL4 SLC7A11 PCBP1 VIT CISD1 NOX3 HMGCR STEAP3 GCLC HEL-S-102 GSC HEL-S-64p PMC8382288__SF1 Dual regulation of osteoclastogenesis and osteogenesis for osteoporosis therapy by iron oxide hydroxyapatite core/shell nanocomposites BMP6 BMP2 SMAD6 MSC NFATC1 TRAF6 PMC8992566__F1 Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms CORT TBP PMC8992566__F4 Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms LTB MAPK4 RB1 CD40 STAT3 AURKA SOX2 EZH2 PTEN SRC ONECUT2 CTNNB1 PMC3549674__F1 New and emerging treatments for estrogen receptor-positive breast cancer: focus on everolimus RHEB TSC2 TSC1 EGFR GSK3B PTEN IGF1R SRC DEPTOR CCND1 PMC8879274__F1 Potential to Fight Obesity with Adipogenesis Modulating Compounds LPL PPARG CEBPA SAG PDGFRA LRP5 UCP1 SMO PPARGC1A CTNNB1 PMC7354287__F7 Androgen-binding AR inhibits TGF-Beta-related Pathway SMAD2 SMAD4 PTEN CTNNB1 PMC11572637__F1 Elafibranor on alcohol-associated liver disease in mice NR1C1 TLR4 HEL-S-44 PMC7565591__F3 Coupling of signal transduction and (default) pathways affecting mRNP formation and mRNA fate DCP2 XRN1 EDC4 DCP1A TRAF6 PMC2999229__F1 Hypothetical model for the molecular signaling pathways of vasculogenic mimicry in tumors and anti-vasculogenic mimicry (VM) therapy strategies GAL BEX2 EPHA2 ID2 MMP2 NODAL PMC10379376__F2 Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells DAZAP2 SOX2 NODAL SLAIN1 TCF3 CDK6 CCND2 LEFTY1 TOB2 LEFTY2 CCND1 MBD2 CDK4 PMC5399913__F3 Anti-recombination and anti-crossover activities of Srs2 during replication and HR mediated DSB repair RAD52 RAD51 PCNA PMC7191165__F2 Classic UPR signaling pathways ATF4 EIF2A TRAF2 PMC7604572__F1 ATP drives ATPase pump, membrane potential and Hh patterning ECD HEL-S-162eP SMO LPP PMC11927159__F3 SLC7A11 Inhibitors Represent a Promising Therapeutic Target by Facilitating the Induction of Ferroptosis in Breast Cancer TF GLS STEAP3 GPX4 HEL-S-64p PMC3307887__F1 Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells CD44 STAT3 LEP PMC3668058__F6 Schematic representation of interacting fatty acid metabolic pathways in wild-type, D1, and D1o3-3 leaves LPA DGAT1 PC PMC11927159__F1 SLC7A11 Inhibitors Represent a Promising Therapeutic Target by Facilitating the Induction of Ferroptosis in Breast Cancer BAX GPX4 SDC1 APAF1 PMC5495058__F2 Signaling pathway in sea urchin sperm GC PMC4469332__F3 The production of BH4 within the DRG plays a critical role in pain signaling SPR PMC6785123__F5 Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma ACTN1 PIK3CA NCK1 PIK3R2 WASL MAL PIK3R1 ACTN2 NCK2 NPHS1 FYN ACTN4 CD2AP CASK PMC5399913__F1 Role of Srs2 in the promotion of PRR RAD18 RAD51 PCNA PMC4469332__F2 Intracellular levels of BH4 depend on three production conduits the de novo synthesis pathway, the recycling pathway and the salvage pathway IFNG CNTF NGF SPR DHFR LIF PTS PMC8043057__F1 Interactions of proteins encoded by studied genes in COVID-19 FH HEL-S-62p THBD CS ADAMTS13 PMC3493385__F2 RNAseq Analysis of the Parasitic Nematode Strongyloides stercoralis Reveals Divergent Regulation of Canonical Dauer Pathways NCR1 NCR2 IGF1 SGK1 PPM2C PTEN SKI ADA PMC4553214__F2 IPA analysis based hnRNPD networks in oral cancer RTCB RBMX FUS ARID1A DKFZp434N041 HNRNPA0 AGO2 RPS14 TRIM2 ATXN2 SNRPD3 MTOR KHDRBS1 TIAL1 RPS16 HNRPR ELF4 SMARCE1 SMARCC2 HNRNPH1 RPS3 HNRNPK RBM14 HNRNPAB HNRNPL MYL6 AGO1 RPS2 RPLP0 HNRNPD TFG KHSRP YBX1 ILF3 RPL13 TAF15 PABPC1 RPL6 HNRNPF SF1 NONO ELAVL1 HNRNPC DDX3X CP NCL PMC10379376__F5 Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells DNMT3B SUZ12 TCF3 LATS2 ASH1L SOX2 WEE1 EZH2 PMC11608829__F6 miRNAs and circRNAs role in pathogenesis CEBPA PMC5611871__F1 AMPK-activating drugs that reduce cellular ATP levels, such as the antidiabetic metformin, promote tumor suppressive actions in a LKB1-dependent manner RHEB MLST8 TSC2 TSC1 PTEN MTOR DEPTOR PMC4946926__F10 The proposed model for production of IFNB in response to extracellular dsRNA TBK1 TLR3 IL6 TRAF3 SRC TRAF6 PMC5436728__F1 Deconstructing the Complexity of TGFB Signaling in Hematopoietic Stem Cells: Quiescence and Beyond TF SMAD2 SMAD4 RHO TGFBR1 PMC7303082__F6 Adenosine affects the B cell receptor pathway SYK BTK PLCG2 PMC4284624__F1 ITCH E3 ligase in ATM network LATS1 JUN ITCH ATM PMC8206147__F8 Schematic diagram of METTL14-mediated lncRNA OIP5-AS1 implicated in the Progression of PTC ADAMTS8 EGFR METTL14 PMC7084349__F1 Cellular mechanisms mediating activity-dependent translational control EEF2K ELF2 EEF2 MTOR PMC7084349__F2 Translational control in antidepressant action EEF2K EEF2 MTOR BDNF PMC3828572__F8 mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions PTEN MTOR KRAS PMC5610547__F5 Metabolic pathways BAD MTAP SMS CS HP PMC8106838__F4 Therapeutic toolkit to modulate Notch signalling ADAM17 RIN1 RBPJ PMC8106838__F2 Skin architecture and Notch pathway member distribution NOTCH2 NOTCH3 NOTCH1 PMC8106838__F1 An overview of Notch maturation, activation and processing ADAM17 SI RBPJ PMC6541695__F2 IGF-2 bioactivity at the surface of an ovarian granulosa cell IGF2R INSR IGFBP2 STC1 IGF2 IRS1 PMC7545699__F7 Schematic diagram illustrating the role of repression of FGF signaling in inducing Dnmt3b inhibition during early development of IVF embryos DNMT3B FGF7A SP1 FGF2 PMC9388540__F6 Molecular model of FMRP-mediated regulation in GSCs WNT5B GSK3B CTNNB1 PMC2647163__F3 Advances on the Understanding of the Origins of Synaptic Pathology in AD CDK5 FYN INSR GSK3B ARC BDNF RAC1 PMC5376330__F9 Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway VASP FPR2 RAC1 PMC8582326__F2 Microtubules as Major Regulators of Endothelial Function: Implication for Lung Injury CLASP2 RHO HDAC6 PMC10476430__F2 Underlying upstream and downstream mechanisms of cardiokines that mediate the heart-to-adipose tissue communication PCSK9 FSTL1 FGF21 FGFR1 LDLR MTOR MED13 PMC5577134__F3 Biosynthetic gene cluster and proposed biosynthetic pathway of ilamycins C6 HEL-S-62p LIAS C2 PMC5244394__F9 Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation EGF EGFR ChAT PMC7022878__F10 Summary suggesting the mechanisms of LUT attenuated hepatotoxicity induced by PbAc NOS2 KEAP1 IL16 GPX1 HEL-75 PMC8457865__F8 WNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M STAT3 WNT16 SHC1 OSM OSMR PMC2909029__F2 A possible mechanism for the inhibitory effect of p66Shc on mitogenic signaling EGF EGFR GRB2 PMC6135780__F1 Extracellular signalling roles of S1P MFSD2B SPNS2 ELL PMC7730311__F1 Immune interaction and metabolic character of tumor cells and the mechanism of immune checkpoint inhibitor and metabolic intervention CD80 SLC16A7 HEL-S-133P APC HIF1A SIRT6 PMC4681601__F1 Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy IDO1 TLR4 APC TLR9 IRF1 KIT AHR SOCS3 FOXP3 MTOR PMC3131061__F1 TIR and NFKB signaling pathways TLR3 BCR IRAK1 TRAF6 EDAR IRAK4 MYD88 PMC5663846__F1 Kynurenine pathway KMO HAAO AHR PMC3638621__F11 The pathway map of urea cycle NAGS HEL-S-20 OTC ARG2 PMC11552425__F2 Whole-exome sequencing in cerebrovascular diseases CHST14 PDE4DIP NTM EDIL3 TMEM132B NFX1 TRPV3 ACOT4 MUC5B PLOD3 ADAM10 TPO ACVRL1 NOTCH3 PMC9284488__F3 LPS-mediated atherosclerosis TIRAP TLR4 TNF MYD88 PMC11039815__F1 Harnessing the cGAS-STING pathway to potentiate radiation therapy: current approaches and future directions TBK1 CGAS ABCC1 IRF3 SLC19A1 PMC6660578__F4 Genetic risk factors and synapse dysfunction in AD pathogenesis ADAMTS4 SORL1 APOE BIN1 PTK2B PSEN1 FERMT2 PICALM TREM2 PLCG2 CLU CD2AP PSEN2 ABO ADAM10 PMC6125308__F2 c-Met/INSR crosstalk in hepatocytes HGF INSR IRS1 PMC2930673__F2 Transport of heme synthesis intermediates and heme in metazoans SLC25A38 CPOX ABCB6 BACH1 ABCG2 FECH PMC5257030__F8 Scheme of the interaction between the intrinsic apoptosis, autophagy and stress response pathways governing the HepG2 response to CdS QDs BAX ATG3 DNAJB9 ATG14 BCL2 APAF1 PMC4817777__F5 Regulatory pathway leading to colon cancer–promoting splicing aberrations PTBP1 HEL-S-30 MYC PMC8254267__F2 Gut microbiota-mediated immunomodulation in tumor LTA CXCR6 COX2 TLR4 CXCL16 PTGER4 FOXP3 MYD88 PMC2930673__F1 Cellular iron processing TF ABCB7 FES PCBP1 ABCB10 PMC7201932__F7 Graphical summaries TGFB1 BMP2 PMC8183409__F2 Mutations in PTEN and TSC1/2 are associated with dysregulation of translation and transcription RHEB TH TSC2 RYK PMC4019504__F5 Integrated Analysis of Genome-wide Copy Number Alterations and Gene Expression in MSS, CIMP-negative Colon Cancer CD44 MAP3K7IP1 DKK1 APP TCF4 MDM2 NLK SRC SFRP1 WIF1 CTNNB1 PMC8997154__F2 Impact of Cannabinoid Compounds on Skin Cancer BAX LOX BCL2 GPR55 TRIB3 PMC5131753__F2 Possible mechanisms of ribosomal proteins L5 and L11 signaling to MDM2 RPL5 RPL11 MDM2 PMC7477357__F1 Coagulation cascade and the fibrinolytic system TF TFPI F2 APC PLG PMC8152462__F4 Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs MAX STAT1 ATF1 ATF2 MYC TNF PMC2920636__F5 Molecular networks over-represented by E VEGFC ANKRD1 PLAT RPL12 GRPEL1 MRPL2 PLAUR THBS2 PLG MYCBP MYC PMC10297006__F2 Ezrin controls several major cellular functions through the regulation of downstream signaling transduction pathways SP1 SIX1 RHO PMC2266794__F4 Integrative Genome-Wide Expression Analysis Bears Evidence of Estrogen Receptor-Independent Transcription in Heregulin-Stimulated MCF-7 Cells MOS EGFR NEK2 HEL-S-11 NLK NPAT DAO PMC4617749__F4 Kyoto Encyclopaedia of Genes and Genomes (KEGG) annotated the Toll-Like Receptor Signalling Pathway as significantly enriched in the RNA-seq dataset for HC CD40 CD80 TIRAP CTSK TLR9 CD14 IRAK1 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 RAC1 MYD88 STAT1 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 LBP IL1B FADD PMC4221383__F3 Developmental Pathways Activated in Melanocytes and Melanoma RAF1 MAK EDN1 EDNRB PMC5583221__F1 Mechanism of axon degeneration and sites of action of chemotherapeutic drugs NGF SARM1 NMNAT1 NMNAT2 PMC9395689__F7 RAGE pathway activation and function in chronic kidney disease and COVID-19 LPA HMGB1 S100A8 PLG APP S100B PMC9395689__F5 RAGE pathway activation and function in chronic kidney disease and COVID-19 HMGB1 SMAD2 SIRT1 PMC9395689__F6 RAGE pathway activation and function in chronic kidney disease and COVID-19 HMGB1 CCL2 PMC8430758__F4 Usage of Natural Volatile Organic Compounds as Biological Modulators of Disease TLR4 CD14 TNF LBP MYD88 PMC9395689__F3 RAGE pathway activation and function in chronic kidney disease and COVID-19 TRPC6 RAC1 NOTCH1 PMC9395689__F4 RAGE pathway activation and function in chronic kidney disease and COVID-19 SMAD2 PMC4767650__F2 INHIBITOR OF APOPTOSIS PROTEINS AS INTRACELLULAR SIGNALING INTERMEDIATES BAX PMC8430758__F6 Usage of Natural Volatile Organic Compounds as Biological Modulators of Disease BAD FAS BCL2 MTOR MYC FADD EIF4E PMC3983720__F8 Diagram of putative mDA differentiation pathway based on this and other studies TH SMAD1 DKFZp781O1323 LMX1A PITX3 SHH FOXA2 PMC12140325__F8 KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration through Regulation of Wnt/B‐catenin signaling Pathway MKI67 AURKA KLF1 LRP6 CTNNB1 PMC8552907__F4 Enrichment analysis for specific cellular pathways NUP155 SEC61A1 THOC2 RAB5C RAB4A CANX RAB7A DDOST SSR1 AAAS STUB1 BAG2 WASHC5 CLTA HEL117 AP2A1 AP2A2 PDCD6IP PABPC5 THOC1 THOC3 ARFGAP2 NUP58 NUP42 THOC7 AP2S1 ALYREF SEC23A CAPZA2 NUP205 ACIN1 FMR1 MAGOH AP2M1 GCS1 EIF3G RPN2 EDEM3 THOC6 NUP93 RPN1 NUP54 HLA-C NUP210 HLA-A RNPS1 CDC42 LMAN1 RAB10 HEL-S-107 UBE2G2 ARPC2 ARPC3 HEL-S-269 GANAB SNX6 IGF2R TFRC EIF2S1 PRKCSH ARFGAP3 CYFIP2 SMAP2 RAB11FIP1 EIF4A1 NGLY1 CLTC HSP90AB1 RNF5 HEL-S-89n RRBP1 EIF2S3 SEC23B HEL-68 ZFYVE16 SEC31A HEL-S-125m HYOU1 RAB35 DNAJB11 SNX2 DNAJA2 STAM2 STT3B PMC5520455__F2 Schematic depiction of reported effects of mammalian caspases in autophagy-related effectors ATG3 ATG16L1 ATG5 BCLAF1 PMC9656741__F3 PSEN2 Thr421Met Mutation in a Patient with Early Onset Alzheimer’s Disease SACS SETX SYT11 SLC24A4 VPS11 LRRK2 TMEM106B SORL1 SPG11 CASS4 ATXN2 EPHA1 FIG4 CD33 PSEN2 NOTCH3 PMC8170084__F1 Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease YTHDC1 HNRNPA2B1 RBM15 WTAP VIRMA METTL14 YTHDF2 YTHDF1 HNRNPC ELF3 PMC4641911__F3 Schematic representation of a hypothetical pathway in neurodegeneration involving stress signaling to and from the Golgi CDK5 CDKN1B LMTK2 PMC4585638__F3 ‘Obesity’ is healthy for cetaceans? Evidence from pervasive positive selection in genes related to triacylglycerol metabolism PLCB4 GPAT2 CD36 MLXIPL ACACA MGLL FABP6 LPA GNPAT PLCG2 DGAT2 CIDEA PC GOT2 ACSL6 ACSL5 SREBF2 SERTAD2 FABP4 PLCH1 MOGAT2 PLCH2 PLCD4 PLCE1 PDE3B FABP2 PLCB2 PMC4711159__F2 Mechanisms regulating CD4+ and CD4+CD25+forkhead box protein 3 (FoxP3) balance CD40 CD80 APC IL2 CTLA4 FOXP3 PMC11899884__F4 PI3K/AKT/mTOR-mediated autophagy by NPs in cancer therapy RHEB TSC2 TSC1 PMC5500564__F3 Differential gene expression in the tamoxifen metabolism pathway CYP2C9 CYP3A4 PMC5500564__F4 Differential gene expression in xenobiotics metabolism pathway between Asian American and Caucasian American DIO1 GNE NAGK DUT PMC9027240__F2 Target Therapy for Hepatocellular Carcinoma: Beyond Receptor Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors KIF7 SUFU SMO PMC9027240__F3 Target Therapy for Hepatocellular Carcinoma: Beyond Receptor Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors LEP APC GSK3B LRP5 LRP6 CTNNB1 PMC11899884__F1 PI3K/AKT/mTOR pathway in Cancer TSC2 TSC1 PTEN DEPTOR PMC5811448__F9 Model linking the adaptive and innate immune responses during tumour development via IL-33-ILC2 axis CXCL9 TH STAT1 IL33 CXCL10 PMC6278270__F1 The main molecular pathways linked to inflammatory and immunomodulatory activities modulated by Curcumin and Echinacea TLR4 IL1B MYD88 PMC3003336__F4 FLCN pathway TSC2 BAD TSC1 FNIP2 FLCN PTEN FNIP1 PMC6016849__F1 O-Linked Beta-N-acetylglucosamine (O-GlcNAc) Modification: A New Pathway to Decode Pathogenesis of Diabetic Retinopathy OGA OGT PGM3 HK2 PMC9317121__F9 BMP Signaling Pathway in Dentin Development and Diseases TF SMAD1 DKFZp781O1323 SMAD2 BMP2 SMAD6 SMAD4 BMP5 PMC8631517__F9 EMS1/DLL4-Notch Signaling Axis Augments Cell Cycle-Mediated Tumorigenesis and Progress in Human Adrenocortical Carcinoma CDC2 DLL4 ESM1 PMC5949932__F2 Regulating network of exosomal proteins and ncRNAs in tumors JAM2 MYB ABL2 LAMC2 S100A8 MMP9 S100A9 PMC4570614__F7 Dynamic differentially expressed (DE) genes were involved in T and B cell development as well as innate and adaptive immune response TH IL10 IL13 APC BLNK IL6 FOS MYD88 IFNG CDA IL2 LBP FADD IL12RB1 PMC8781713__F6 LRG1: an emerging player in disease pathogenesis TF STAT3 EGF HMFT1766 SMAD1 DKFZp781O1323 EGFR SMAD2 SMAD4 CTNNB1 ENG RUNX1 ROCK1 PMC5876636__F2 TGFB1 signaling via SMAD-dependent/independent pathways TGFB1 THY1 PLOD2 VCAN PMC7797639__F7 [missing figure legend] JMJD8 EGF EGFR PMC1193608__F8 Model of HAV interaction with the dsRNA-induced IRF-3 activation pathway TBK1 TLR3 TANK IRF3 PMC6375072__F1 Molecular signaling mechanisms of nicotine mediated anti-inflammatory effects STAT3 HMGB1 PMC4811984__F6 Reduced dopaminergic transmission in the mesolimbic pathway may overrule orexigenic signals from the arcuate nucleus TH POMC NPY ARC AgRP PMC8346982__F2 Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment CD44 HAS3 HAS2 HYAL2 CTNNB1 TGFBR1 PMC8346982__F3 Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment CLU PMC5067692__F1 Newly synthesized FGFR1 can enter either the constitutive membrane pathway or regulated nuclear pathway in membrane pathway the receptor is processed and glycosylated in Golgi and accumulates in plasma membrane VIT NGF BMP7 PMC6689231__F2 Insulin signaling pathway INSR PDPK1 IRS1 PMC6158369__F1 Primary and acquired resistance to CD38 antibodies CD59 CD55 PMC8081604__F9 Polydatin Attenuates OGD/R-Induced Neuronal Injury and Spinal Cord Ischemia/Reperfusion Injury by Protecting Mitochondrial Function via Nrf2/ARE Signaling Pathway BAX KEAP1 NQO1 MAF PMC10341681__F6 Signaling pathways and targets of saponins against apoptosis in AD BDNF TRAF2 SOX8 CTNNB1 PMC7229901__F1 Treg-mediated suppression CD80 TIGIT AREG PMC9249680__F2 Engineering Yarrowia lipolytica to produce nutritional fatty acids: Current status and future perspectives LPA FAS PC GPD1 POT1 PMC4265676__F7 Schematic model of WRAP53B function in the DDR pathway RAD51 BRCA1 TUB RNF168 H2AX RNF8 ATM MDC1 PMC8133800__F1 Decorin as a possible strategy for the amelioration of COVID-19 SMAD2 SMAD4 PMC10341681__F2 Signaling pathways and targets of AB metabolism regulation by saponins IDE AXL TFEB APP ADAM10 PMC10341681__F3 Signaling pathways and targets of saponin-regulated tau protein phosphorylation CDK5 LCMT1 IRS1 PMC8774728__F1 New Strategies and Combinations to Improve Outcomes in Immunotherapy in Metastatic Non-Small-Cell Lung Cancer IFNG CD80 TIGIT CGAS PMC10514522__F2 Microglial metabolism shifts from OXPHOX to glycolysis in the inflammatory state HEL107 CAD COX2 MTOR MYD88 PMC10341681__F4 Signaling pathways and targets of saponins against neuroinflammation in AD CDK2 NOX4 SOX8 CTNNB1 PMC10514522__F3 Lipid metabolism in microglia in the inflammatory state TREM2 FAS CD36 APOE LDLR NFKBIL1 PMC10341681__F5 Signaling pathways and targets of saponins against oxidative stress in AD HEL-S-22 GCLC NOX4 CTNNB1 PMC10254162__F11 FAK/Src signaling pathway CDC42 CRK SRC DOCK1 PMC8497485__F3 Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer STAT3 STAT1 ARG1 IRF8 MTOR JAK1 IL1B MYD88 PMC3582104__F1 The intracellular signaling pathways modulated by somatostatin receptors BAX SRC SST PMC4593735__F1 Innate immune interactions within the central nervous system modulate pathogenesis of viral infections TBK1 CGAS MAVS NLRP3 RNASEL IFIT2 IRF3 EIF2A MYD88 PMC7484982__F3 Reign in the membrane: How common lipids govern mitochondrial function PGP CDS2 CHPT1 PRELID1 FLJ10842 TAMM41 LPA STARD7 PGS1 PRELID3B PSD CDS1 PEMT PC CEPT1 PMC4996658__F2 Co-ordinating Notch, BMP, and TGFB Signalling During Heart Valve Development SMAD2 SMAD4 RBPJ PMC7484982__F4 Reign in the membrane: How common lipids govern mitochondrial function BAX CERT1 tmp_locus_29 MFF PMC5414836__F3 Cytokine Decoy and Scavenger Receptors as Key Regulators of Immunity and Inflammation STAT3 IL1R1 IL33 PTEN MTOR IL1B MYD88 PMC4996658__F3 Co-ordinating Notch, BMP, and TGFB Signalling During Heart Valve Development SMAD1 SMAD2 PMC9230742__F6 Combined Transcriptomic and Proteomic Profiling to Unravel Osimertinib, CARP-1 Functional Mimetic (CFM 4.17) Formulation and Telmisartan Combo Treatment in NSCLC Tumor Xenografts STAT3 BAX OSM EGFR SOX2 AGA PMC4975441__F4 Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells EPOR EPO SOCS3 PMC8555376__F1 Race to stymie BTK: zanu zings STAT3 CXCL12 SYK BTK BCL10 BCR CARD11 IRAK1 LYN MTOR CXCR4 MYD88 PMC11670978__F9 Pathway of action of HnAg in treating UC mice MUC2 AHR TNF PMC11048596__F4 Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma SPN CD2 FSTL1 RPSA BMP2 CER1 PTPRC TLR7 RPS12 PMC11048596__F5 Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma C6 FSTL1 E2F2 RPSA TNFRSF1A SLC2A3 RPL19 DKK3 DDB2 FRAT1 RPL18A CTBP2 MAFF ID4 BMP2 RPS12 MDM2 PMC4975441__F8 Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells EPOR EPO SOCS3 PMC11711721__F7 Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/Beta-catenin pathway modulation APC GSK3B CTNNB1 PMC11048596__F6 Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma FRAT1 SMAD1 DKFZp781O1323 FSTL1 APC BMP2 CER1 SMAD4 MDM2 CTNNB1 PMC7031145__F7 Phosphoinositide-3-kinase, phosphatase and tensin homolog, p38 mitogen-activated protein kinase and RAS pathways modulated by caffeine EGFR PTEN MTOR PMC2834246__F2 Regulation of chromatin structure by drugs of abuse CDK5 FOSB HDAC5 NPY BDNF PMC3391582__F2 Signaling Circuitries Controlling Stem Cell Fate: To Be or Not To Be RHEB TSC2 LRP5 LRP6 MTOR GPR49 LGR6 PMC2790539__F1 Apoptosis in cerebral ischemia and reperfusion BAX BAD FAS CAD PMC3280275__F6 Kinome-Wide Functional Genomics Screen Reveals a Novel Mechanism of TNFAlpha-Induced Nuclear Accumulation of the HIF-1A Transcription Factor in Cancer Cells TRPM7 ADCK2 TRIB2 HIF1A PMC7031145__F6 Inhibition of transforming growth factor B pathways caused by caffeine TGFBR2 SMAD2 SMAD4 CTGF TGFBR1 PMC5808116__F8 H. pylori T4SS induces potent IL-8 induction EGR1 EGFR HP PMC5029667__F7 PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells MDM4 PIM1 MDM2 PMC11036351__F1 Hyper-Responsive Chemiluminescent Probe Reveals Distinct PYRase Activity in Pseudomonas aeruginosa GAL MB PMC3794591__F5 Pathway map of fatty acid metabolism SP4 POT1 PMC8165240__F1 Cannabinoid Signaling in Auditory Function and Development PTPN22 DAGLA DAGLB ABHD12 ABHD6 COX2 F2 ABHD4 FAAH GDE1 PMC5867015__F2 Signalling pathway of Pak1 in the heart CDC42 PLN PAK1 RAC1 FBXO32 PMC4405647__F13 Schematic presentation of molecular mechanisms by which acidosis controls the mTORC1 and eEF2K pathway to shut down protein synthesis and aid cancer cell survival RHEB EEF2K TSC2 TSC1 PMC9454586__F2 Oncostatin M: From Intracellular Signaling to Therapeutic Targets in Liver Cancer STAT3 STAT1 SOCS3 JAK1 PMC8349405__F3 Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens SMS SRM SMOX EIF5A PAOX DOHH DHPS PMC3904630__F9 OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness NRL CRX NEUROD1 NR2E3 OTX2 RORB PMC8349405__F5 Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens TBK1 STAT1 MAVS IRF9 IRF3 JAK1 TYK2 MYD88 PMC9475269__F2 Amino acid metabolism in skeletal cells ASL GLS SLC7A7 SLC1A3 SLC38A1 ATF4 PTH PMC9475269__F3 Amino acid metabolism in skeletal cells ACAN SOX9 GLS PMC10961392__F2 Recent advances of myotubularin-related (MTMR) protein family in cardiovascular diseases RYR2 CGAS MTMR3 MTMR2 MTMR8 CRH MTMR9 MTMR4 MTMR6 MTM1 MTMR1 PMC4645172__F5 Glatiramer acetate treatment negatively regulates type I interferon signaling STAT1 LTA TLR3 TLR4 IRF3 ATF2 TNF MYD88 PMC6123652__F3 Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments POLD3 RAD52 RAD51 WRN BRCA2 PARP1 XRCC3 FANCB FANCD2 CHD4 RAD51C SMARCAL1 MRE11A DNA2 BRCA1 HLTF ZRANB3 RADX FBXO18 PMC3110186__F5 Unraveling Molecular Signatures of Immunostimulatory Adjuvants in the Female Genital Tract through Systems Biology IFNG IL10 RNASEL REL TNF IL1B MYD88 PMC2746238__F2 Induction of autoimmunity by pristane and other naturally-occurring hydrocarbons TBK1 TLR3 TLR4 CCR2 TLR9 TLR8 TLR7 MYD88 PMC5987909__F4 Stiffness-induced acute lung injury and pulmonary hypertension CTSK PAH RHO PMC3544185__F6 Complex Patterns of Altered MicroRNA Expression during the Adenoma-Adenocarcinoma Sequence for Microsatellite-Stable Colorectal Cancer SAA1 ARHH ROCK2 APC SKP1 HEL-S-11 PROC PMC6541445__F3 Cellular mechanisms and signals that coordinate plasma membrane repair CDC42 RHO PMC10819745__F3 Pattern diagram of immune cell response process triggered by PRR signal triggered by HSV-1 infection TBK1 CGAS MAVS MAL TLR9 IRAK1 IRF3 IFI16 TRAF3 TRAF6 IRAK4 MYD88 TLR3 INF2 TLR8 TLR7 PMC7539815__F4 Proposed GnRH-analog effect on NAV3 and resultant effect on leiomyoma development GNRHR NAV3 CTNNB1 PMC6585524__F1 Photic signaling pathways involving main kinases activities in the circadian clock VIP PER2 PER1 CRY2 GC BDNF PMC6610579__F3 Schematic summary of molecular pathways induced by HBx-B genes LAMC2 FOXO1 PAK1 SULT2A1 PAK6 ALOX12 SRC CYP3A4 IGF2 SPP1 PMC5873314__F1 Theoretical model of how genetic polymorphisms influence symptom burden during breast cancer treatment NGF BDNF PMC7724080__F2 Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) ATR RAD50 PARG BRCA2 RIF1 SHLD3 SHLD2 SHLD1 MRE11A BRCA1 SLFN11 ATM PALB2 PMC4335352__F5 Example of non-mitotic functions of Plk1: effects on the mTOR pathway RHEB RPS6 TSC2 EIF4B TSC1 ULK1 BRAF EIF4E PMC5535966__F8 G-protein signaling of LW pigs ADRBK1 BTK CSK PC PMC8941195__F2 RAS/MAPK pathway JUNB ATF2 GRB2 PMC8941195__F3 a. PLCG signaling pathway and b. PI3K pathway PDPK1 PMC7956994__F1 Complement system with focus on most relevant targets for therapeutic inhibition CRP C6 PTX3 CD59 FH C7 HEL-S-62p C4A CR1 C5AR2 C2 C9 C4B_2 PMC8027469__F2 Investigating the Underlying Mechanisms of Circular RNAs and Their Application in Clinical Research of Cervical Cancer MDM4 RAF1 ITGB1 QK3 PCNA EIF3C EGFR SMAD4 MDM2 PMC4258146__F2 Canonical Wnt/Beta-catenin signaling DKK1 GSK3B LRP5 LRP6 PMC12238443__F2 Current model of the BR signaling pathway in Arabidopsis thaliana BIN2 BAK1 ABCB1 PMC8431670__F3 UBL5/Hub1: An Atypical Ubiquitin-Like Protein with a Typical Role as a Stress-Responsive Regulator FANCD2 YAP1 PMC8036867__F2 Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1A) in the onset of Parkinson’s disease TFAM PINK1 GPX1 PMC7005498__F1 Cartoon Illustrating the UPR Pathway Involving Multiple Organelles and Three Branches, Several TFs, and Downstream Molecules Involved in Feedback Loops ATF4 EIF2A PMC11351691__F4 Hub proteins were obtained and verified by molecular docking P2RX7 BRD4 PIK3CA EGFR BRAF NAMPT HEL-S-30 IDO1 TLR4 F10 PTGS1 CREBBP AHR CYP2C9 CNR1 KDR ABCG2 PMC8139654__F11 Microfilaments and Microtubules Alternately Coordinate the Multistep Endosomal Trafficking of Classical Swine Fever Virus CDC42 PAK1 LIMK1 EGFR ROCK1 ARHA RAC1 PMC7725584__F2 Active compound-potential target network CSA2 PPARG PGR LYZ MTOR CCNA2 NOX4 MAOA MAPK3 FOSL2 LCT CHRM4 PIG59 CDK6 PRKCE F2 F10 MMP2 ACHE NOS2 JUN SELE FASN PTGS2 OPRM1 VEGFA IL6 NCOA1 IGF2 FOS NR3C2 GFAP CHRM2 AGER RELA RXRA BCL2 CISH BIK SELP PMC11049935__F5 Plant hormone signaling pathways and related DEGs TF BIN2 EBF2 PMC2993603__F1 A tincture of hepcidin cures all: the potential for hepcidin therapeutics STAT3 BMP6 TWSG1 GDF15 LIF TMPRSS6 HFE2 PMC5076770__F2 The biological complexity of colorectal cancer: insights into biomarkers for early detection and personalized care STAT3 EGF HGF COX2 APC GSKIP PTEN MTOR SRC PMC8683220__F2 Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight. VCAM1 TNF PMC5471631__F8 RIPK1 and RIPK3 kinases engage the IFN-I pathway downstream of the adapter protein TRIF RIPK3 TBK1 MLKL TLR4 RIPK1 IRF3 PMC6610579__F5 The schematic image of HBx/AKT/FOXO1 signaling pathway and AA metabolism induced inflammation LTB ALOX12 CTNNB1 PMC5683904__F7 Schematic to illustrate model of Wnt pathway FOXJ1 DKK1 GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC6851170__F9 The anti-TGEV effect of Lp-1s STAT1 IFNAR2 IFNAR1 OASL MX2 ISG15 JAK1 PMC3073855__F1 Childhood Obesity – 2010: Progress and Challenges TRH PYY CRH POMC NPY AgRP BDNF PMC2837985__F9 Proposed model for the regulatory mechanisms of the Ras and cAMP signaling pathways in stress response and antifungal drug susceptibility in C CDC42 GSC2 MSH6 MND1 PKP1 PMC7432085__F5 Pathway studio network analysis of PLA2R1 and PLA2R1 promoter methylation in breast cancer ESRRA MYC PMC9139316__F1 Detecting DNA: An Overview of DNA Recognition by Inflammasomes and Protection against Bacterial Respiratory Infections RIPK3 TBK1 CGAS GSDMD ZBP1 NLRP3 CASP5 CASP4 AIM2 IRF3 IFI16 IL1B PMC8113812__F3 Role of exosomes derived from serum in sepsis SOCS1 HMGB1 BAD FAS IL4 MTOR TNF IL1B MPO MYD88 PMC8878749__SF2 Nanosized Codelivery System Based on Intracellular Stimuli-Triggered Dual-Drug Release for Multilevel Chemotherapy Amplification in Drug-Resistant Breast Cancer CD44 PNP PTS PMC8113812__F5 Role of exosomes derived from epithelial and endothelial cells in sepsis ROCK1 IRAK1 PTEN TRAF6 TNF IL1B PMC7560934__F1 Diagrammatic representation of Beta-cell function NR2A1 GCK PMC8660205__F6 Network Pharmacology and Molecular Docking Study of Zhishi-Baizhu Herb Pair in the Treatment of Gastric Cancer PLN MYB BAD GAL RBL2 CYC1 PTEN CD19 TSC2 tal-1 CD37 APP MDM2 PMC5504167__F2 Corticotropin-releasing hormone (CRH) controls the placental “surveillance and response” system so that the fetus can detect threats to survival and adjust its developmental trajectory CRH NR3C1 PMC6456712__F1 MHtt aggregation, generation of ER stress and the consequent UPR protective and later pro-apoptotic responses KEAP1 ATF4 EIF2A PMC9700492__F5 Transcriptomic and metabolomic insights into the role of the flgK gene in the pathogenicity of Pseudomonas plecoglossicida to orange-spotted grouper (Epinephelus coioides) SYK IL10 PLCG2 RELB CALM1 NFATC1 NFATC3 EGR2 IL1B PMC4738349__F10 Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis RIPK3 MLKL RIPK1 PMC4065342__F2 The biosynthesis pathway of the major terpenoids in plants IPP ME2 MBP PMC2291295__F1 Keratinocyte Apoptosis in Epidermal Development and Disease BAX FAS PMC4001725__F2 Estrogenic Steroid Hormones in Lung Cancer EGF IGF1 HRG MTOR SRC PMC3299342__F3 Signaling by PERK, IRE1, and ATF6 ATF4 EIF2A XBP1 TRAF2 PMC9663996__F5 ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis HMGB1 GSDMD NLRP3 IL1B MYD88 PMC2291295__F2 Keratinocyte Apoptosis in Epidermal Development and Disease EGF NGF BAD HGF EGFR PMC12108044__F5 KEGG pathway enrichment analysis TNF PMC9528626__F2 OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases CD44 CD74 COX2 MIF IL8RB SRC CXCR4 PMC7241622__F1 Intracellular signaling pathways examined (A) and the experimental protocol used (B) TG REST PMC12096500__F8 Proposed mechanism of PSVII treatment in psoriasis involves the modulation of the STAT3/NFKB signaling pathway and the regulation of pyroptosis STAT3 GSDMD NLRP3 IL18 PMC5322464__F3 MapMan overview of significant (FDR adjusted p ≤ 0.05 & log2 fold change ≥2) differentially expressed loci (SDEL) involved in biotic stress pathway, unique to PB1+Pi9, upon M MYB ERF MSC PMC4556464__F2 Hedgehog signalling pathway showing development of TNBC FAS SMO PMC6279938__F1 Impact of i-proteasome subunits on innate immune signaling in myeloid cells CD40 CD80 TLR9 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR3 TLR4 CCR7 TLR7 IL1B PMC6398499__F4 Crosstalk between Wnt, RA and related signaling pathways in orofacial clefts CYP26B1 ALDH1A3 TBX1 LRP6 FGF10 PMC4584337__F2 Comparison between the biosynthesis of isoprenoids in photosynthetic organisms (A) and the biosynthesis pathway proposed in haloarchaea (B) IPP C2 CS PMC10375653__F2 Involvement of the SIRT1-NLRP3 pathway in the inflammatory response NLRP3 TLR4 IL1B PMC2637651__F3 Transcriptomes in Healthy and Diseased Gingival Tissues MAX EGF FAS MOS CRKL CD14 NLK BDNF FLNA STS PMC6400530__F2 Pathogen antioxidant networks: The examples of Mtb and T TH MSRA APC TXN2 PMC8899168__F7 4‐octyl Itaconate inhibits lipopolysaccharide (LPS)‐induced osteoarthritis via activating Nrf2 signalling pathway KEAP1 NQO1 GCLC PMC9072026__F1 Intertwined Relation between the Endoplasmic Reticulum and Mitochondria in Ischemic Stroke BAX CASP9 CASP12 ATF4 PMC10411465__F4 Alterations of polyunsaturated fatty acids metabolic pathways in AAD MMP2 GLA VCAM1 MMP9 PMC3161734__F3 Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii RPE NAGS MME ASL ADK PDC OTC ACD ARG1 FLJ10842 PMC10411465__F2 Gut microbiota-derived metabolites in AAD CUTA CUTC PMC12035886__F1 Mechanism of histone modifications in regulating enzalutamide sensitivity in advanced prostate cancer DOT1L KDM7A HOXB13 PMC10411465__F3 Major amino acid metabolic pathway involves AAD PRMT1 ME3 MMP2 MMP9 SIRT1 ARG2 PMC12035886__F2 Histone modifications drive neuroendocrine differentiation in prostate cancer STAT3 EZH2 PMC8170620__F2 Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection STAT3 BAX DRAM2 NEK6 FOXO3A LNX1 PMC9191761__F1 Non-canonical WNT signalling pathways ROR1 ROR2 RYK ARHA RAC1 PMC8170620__F4 Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection EZH2 PTEN NOTCH2 PMC11700300__F2 Pathogenetic mechanisms of WT1 in AML TET2 WT1 BCL2 MYC CCND1 PMC8170620__F1 Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection STAT3 BAG2 SOCS3 TRAF6 MYD88 PMC8385445__F1 Leigh Syndrome: A Tale of Two Genomes NDUFB8 NDUFA12 TACO1 COX10 NDUFA9 SURF1 NDUFV2 PET100 NUBPL TTC19 NDUFS8 NDUFAF6 UQCRQ NDUFA10 NDUFAF4 NDUFS3 NDUFS4 COXFA4 SDHAF1 NDUFAF2 COX3 SCO2 NDUFAF5 LRPPRC SDHA ZNF183 NDUFA2 NDUFS1 PMC5021578__F2 Genetic Alterations of D-Catenin/NPRAP/Neurojungin (CTNND2): Functional Implications in Complex Human Diseases CDC42 APC GSK3B RHO CTNNB1 PMC6398499__F1 Key components and potential pharmacological targets of Wnt signaling implicated in orofacial clefts FZD2 ROR2 GSK3B LRP6 RYK WNT9B CTNNB1 WLS PORCN MSX1 FZD1 LEF1 TEF PMC6398499__F2 Crosstalk between Wnt, Cdh1, Bmp, TgfB and Fgf signaling pathways in orofacial clefts Pax9 TGFB1 BMP7 TGFBR3 FGFR2 SPRY2 IRF6 GRHL3 ACVR1 MSX1 BMP4 FGFR1 SHH PMC2966547__F1 Homocysteine metabolic pathways HEL-S-61p PMC9394413__F3 Normal and Pathological NRF2 Signalling in the Central Nervous System BACH2 KEAP1 GCLM DPP3 GPX8 HMOX1 GPX2 FTH1 BACH1 FTL BRCA1 NQO1 GCLC BCL2 PALB2 HEL-75 PMC6398499__F3 Crosstalk between Wnt, Shh, primary cilia and other related signaling components in orofacial clefts KIF3A SHH FOXF2 FGF18 CTNNB1 GLI3 PMC7408991__F4 Redox homeostasis and metabolic shift through activation of the Nrf2-Keap1 pathway and regulation of the NAD+/NADH ratio by PM redox enzymes KEAP1 FOXO3A SIRT1 PMC6901795__F7 A schematic model of zbTRIM25-mediated RLR signaling pathway during RGNNV infection TBK1 RIGI MAVS TRIM25 IRF3 TRAF3 TRAF6 PMC3201744__F1 MiR-21, miR-126, and miR-148a directly or indirectly regulate DNMT1 in SLE CD4+ T cells.A TF TNLG8A EGFL7 PMC6770264__F1 Bone metastasis physiopathology: implication of cancer cell-microenvironment interactions and therapeutic targets CXCL12 BMP4 CXCR4 PMC6330604__F1 DSBR pathways and the effect of RAD51 paralog loss on pathway choice RAD51 MRE11A BRCA2 ATM MDC1 PMC8405392__F4 Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology HEL111 PTPRC PTEN PTGS2 MMP9 TNF MAPK8 ALB PTPN22 RARA ALOX5 NR3A2 RELA ADRB2 NFKBIA MMP3 IL2 ELANE PMC2975945__F4 Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS CD40 LTA MAP3K7IP1 LTBR TIRAP NFIB RELB REL LCK PMC6710350__F4 Microglial inflammatory responses by IFNB signaling SOCS1 IFNG STAT3 STAT1 STAT2 COX2 IFNAR2 IRF9 IFNAR1 SOCS3 MTOR TYK2 PMC9394413__F2 Normal and Pathological NRF2 Signalling in the Central Nervous System RBX1 KEAP1 PMC3763042__F1 Working model of renoprotective pathways activated by relaxin NOS2 SMAD2 PMC2975945__F2 Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS TF TIMP1 PIM1 PMC5330146__F2 The SOLLI model predicts targets of therapy NR1C1 SCD CCR2 PMC8232256__F4 Advances in Chemokine Signaling Pathways as Therapeutic Targets in Glioblastoma TH CCR2 CXCL2 CCL2 PMC4402485__F1 Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors HEL-S-92n TLR1 TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 TLR7 MYD88 PMC5283711__F1 Redifferentiating Thyroid Cancer: Selumetinib-enhanced Radioiodine Uptake in Thyroid Cancer NRAS PTEN GRB2 MTOR RET PMC3491909__F1 Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR RHEB MLST8 TSC2 RICTOR TSC1 SGK1 PI3 PTEN PDK2 MTOR DEPTOR PMC5036404__F2 Schematic overview of the molecular pathways involved in necroptosis TRADD TLR3 MLKL TNF CYLD TRAF2 FADD PMC9082937__F7 Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis AXL TLR4 SOCS3 PMC11232677__F7 KEGG pathway analysis of differentially expressed genes on cell cycle pathway in AML patient group with high beta-catenin levels vs controls TICRR CDC14B MAU2 CDC20 PCNA CDC6 CD82 CD7 SMAD4 SKP2 PLK1 CDK7 TTK WAPAL CCNB1 MAD1L1 DBF4 TRIP13 PTTG1 RAD21 MIA MTBP CDC45 DDX11 CDK2 CDC27 CDC25B NIPBL PMC11232677__F8 KEGG pathway analysis of differentially expressed genes on signaling pathways regulating pluripotency of stem cells in AML patient group with low beta-catenin levels vs controls BMPR2 STAT3 SKIL REST DKFZp781O1323 PIK3R3 LIF APC DUSP9 SOX2 SMAD4 NODAL RIF1 CTNNB1 TCF3 FZD3 IGF1 BMP4 TBX3 JAK1 PMC3847898__F1 Wnt signaling pathways and the effects in mature synapses APC LRP5 LRP6 ARHA RAC1 PMC2627520__F2 Biosynthesis of Natural and Hyperelongated Chondroitin Sulfate Glycosaminoglycans: New Insights into an Elusive Process CHSY1 CS CHSY3 CHPF PMC187486__F8 Effects of Cdk4 disruption on the pathways controlling senescence and transformation CDK2 MDM2 CDK4 PMC5731654__F2 Impact of BRAFi on T cell response to melanomas BRAF TYRP1 PMC3742913__F5 Gene pathways revealed by comprehensive genomic profiling SOCS1 MMP16 IFNE CXCR3 STAT3 SYK SMAD1 DKFZp781O1323 MMP12 OSM NCF2 CCR5 JAK3 CCR2 AK3 FHL2 IRAK1 IRAK2 SOCS3 TRAF6 PLK1 IRAK4 MYD88 IL16 CCR7 MMP2 SRC APAF1 CCR1 HEL-S-44 CASP9 CASP8 SP1 STAT2 IRF1 VAV1 TNF CXCL10 RUNX3 HRAS PREX1 TIEG2 BMP1 c-fgr CXCR4 CXCL12 MMP14 TRADD CXCL1 CCR3 RUNX2 TGFBR1 TGFBR2 CASP4 TLR4 IL2 CDK4 IL9 CASP2 EGR1 LIF CXCL16 IL4 IRF4 IL6 CXCL6 PARP1 CD44 CXCL17 RUNX1 ITGB1 IL24 FOXO3A CASP3 CCR4 JAK1 TRAF2 LCK FADD PMC3319919__F2 Components of the TLR pathway and genes commonly induced during the innate immune response of zebrafish to bacterial infection C6 CASP9 TBK1 MYB IL10 HEL-S-62p F5 EBP MAL TAB3 IRAK1 MMP9 HEL-S-78p MYC TRAF6 IRAK4 NCF1 MYD88 MAP3K7IP1 SLC30A1 IRAK3 FGA BIRC2 IL1B PMC3824029__F1 Peripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease SYK CD80 BTK BCR LAT ITK LYN ATF2 GRB2 GATA4 PMC5528934__F2 Genes associated with paclitaxel (A) and gemcitabine (B) mechanism of action (direct targets, metabolizing enzymes), genes previously associated with resistance, and stable genes in the biological pathways targets BAD ABCC1 HEL-S-62p TUBB4B NFKB2 TYMS MAP2 DCTD OPRK1 CSAG2 BIRC5 BCL2L1 ABCC10 TMEM243 CTPS1 CDA TUBB1 CNGA3 HEL74 AK1 SLC29A1 SLC28A3 BMF RRM2B ABCB1 TUBB4A BAX BCAP29 ABCB11 MAP4 RRM1 RRM2 CMPK1 GBP1 FGF2 BCL2 CYP2C8 TWIST1 PMC4342515__F1 ncRNAs affect Akt pathway in cell cycle ING4 SP1 NRP1 SP2 RAB40C RBP2 CDK6 CCND2 ERBB2 CDK2 ATM MDM2 CDK4 PMC3137149__F1 Simplified model of the tuberous sclerosis complex signaling pathway RHEB TSC2 TSC1 MTOR DEPTOR PMC4435677__F2 Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma TP73 HGF MAVS IGF2BP3 VEGFA IL6 YAP1 RB1 CDKN2A MTTP CDKN1A DCLK1 COX2 TLR4 PMC4342515__F2 ncRNAs affect CDKIs and Myc pathway in cell cycle DNMT3B IGF2BP1 CDK6 CCND2 MXD1 CDK2 MTOR CCND1 CDK4 EIF4E PMC9225019__F1 Review of Multiple Myeloma Genetics including Effects on Prognosis, Response to Treatment, and Diagnostic Workup CCND3 CCND2 MAF FGFR3 CCND1 PMC5872179__F2 Proximal T-cell signaling cascade ZAP70 JUN PYY VAV1 MYC REL FOS LCK PMC5036404__F1 Schematic overview of the intrinsic and extrinsic arms of apoptotic signaling BAX BAD FAS TRADD OPA1 BCL2 TNF CYLD TRAF2 FADD PMC12060353__F8 Aseptic inflammation caused by acinar cell injury leads to local tissue hypoxia COL1A1 CXCL1 IL8RB PMC8489222__F2 Targeting smooth muscle cell phenotypic switching in vascular disease TET2 MYOCD GATA6 IRS1 PMC8885929__F4 GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a C. elegans model of Parkinson’s disease ACHE HEL-S-11 DAO PMC137498__F6 Regulation of Cdc25A by Chk1 CDK2 PMC3042531__F3 Regulation of Innate Immunity by signaling pathways emerging from the endoplasmic reticulum TIRAP TLR4 ATF4 IL6 TNF XBP1 MYD88 PMC8489222__F4 Targeting smooth muscle cell phenotypic switching in vascular disease LATS1 LATS2 CCND2 RHO CCND1 PMC3855094__F7 Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects CDC2 STAT3 ALK EGFR FGFR1 WEE1 BRAF CDK2 ITK SRC LCK CDK4 PMC12176010__F1 Research progress on the regulation of autophagy in cardiovascular diseases by chemokines RHEB MLST8 TSC2 TSC1 ULK1 DEPTOR ULK2 PMC3938021__F3 Dissecting the Molecular Basis of the Role of the O-Mannosylation Pathway in Disease: Alpha-Dystroglycan and Forms of Muscular Dystrophy B3GALNT2 B4GALT2 PMC3524152__F2 Bacterial effector targets the TRAF6-NFKB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells MAP3K7IP1 BCL10 TRAF6 PMC2757135__F1 Cholesterol transport in steroid biosynthesis: Role of protein-protein interactions and implications in disease states NPC2 STAR NPC1 CYP11A1 PBR PMC3855094__F5 Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects CDC2 STAT3 ALK EGFR FGFR1 WEE1 BRAF CDK2 ITK SRC LCK CDK4 PMC8194945__F1 Nephroprotective activity of natural products against chemical toxicants: The role of Nrf2/ARE signaling pathway RBX1 KEAP1 MAF IL1B PMC9146859__F2 Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals HMGCR SCARB1 NR3A2 LDLR CH25H ZMPSTE24 ABCA1 MED1 APOA5 PMC4395516__F7 Reported interactions between factors associated with Peters anomaly B3GLCT HCCS FOXE3 PITX3 FOXC1 SLC4A11 TFAP2A CYP1B1 PAX6 FLNA PITX2 NDP PMC7177266__F4 Speculated view of the melanin synthesis pathway MC1R ASIP SLC24A4 BCL2 SOX10 PMC5772929__F1 Mechanism through which metformin exerts its antitumor effects (A) by reducing the level of insulin in serum to inhibit the PI3K/Akt/mTOR signaling pathway and (B) by activating AMPK to inhibit the mTOR pathway RHEB TSC2 BAD TSC1 MTOR CCND1 PMC6753625__F1 Common signaling pathway for IL-1 family cytokines IL1R1 IL33 IL36A TRAF6 PMC8250151__F1 Myeloid-Derived Suppressor Cells as a Potential Biomarker and Therapeutic Target in COVID-19 CCR2 CCL7 ARG1 MTOR CCL2 PMC3250228__F3 FOLATE-ALCOHOL AND CANCER PATHWAY HYPOTHESES CYP2E1 DHFR PMC8584156__F3 Drosophila melanogaster as a Model Organism to Study Lithium and Boron Bioactivity IPP CTNNB1 PMC3613936__F2 Striking the target in iron overload disorders BMP6 TMPRSS6 HFE2 PMC3196888__F8 A model showing the overlapping functions of MMR and FA proteins in ICL and MMR ATR MSH2 MSH3 PMS2 PMC7967251__F4 Potential signaling interactions between LPA and p53 in transformed cells LPA ACP6 KLF5 MDM2 PMC7967251__F2 Crosstalk between the p53 and sphingolipid pathways.The complex interplay of p53 with key enzymes of the sphingolipid metabolic pathway in modulating DDR is shown above CERS5 ATR SPHK1 ATM CERS6 PMC4055201__F8 Schematic diagram illustrating the possible mechanisms responsible for CORM-2 effects on LPS-induced VCAM-1 expression in RASFs JUN VCAM1 TRAF6 FOS MYD88 PMC7013392__F4 Representation of the targets of stemazole (ST) involved in the MAPK signaling pathway MAX ECSIT JUND FAS TRADD NF1 CD14 NLK TRAF2 PMC10413047__F2 LncRNAs regulating the proliferation and apoptosis of NSCLC MDM4 YBX1 PMC10413047__F3 CASC9 and lncRNA UCA1 in drug resistance in NSCLC FOSL2 EZH2 PMC4138268__F8 Schematic representation of smoke-provoked MUC1 glycosylation in regulation of MUC1-C/p120ctn interaction and adherens junction (AJ) disruption EGFR GALNT6 SRC PMC5323396__F1 TLR molecular cascade GSK3B NLK MYD88 PMC5323396__F2 General overview of the Wnt signaling pathway APC LRP5 LRP6 ARHA CTNNB1 PMC5323396__F3 Proposed molecular talking points between TLRs, Wnt, and nuclear factorKB (NFKB) RELA GSK3B LRP5 PIAS1 LRP6 NLK REL RAC1 CTNNB1 MYD88 PMC3166557__F2 Planar Cell Polarity Pathway – Coordinating morphogenetic cell behaviors with embryonic polarity APC ROR2 PTK7 WNT1 RHO DAAM1 CTNNB1 PMC2998095__F7 ID2 in clock resetting ID2 PMC2877959__F3 Uric acid transport and disease MAP4 ABCG2 PMC4590647__F7 rLGALS9 internalization and signaling in CRC RAF1 MAP2K1 ATG5 PMC8172013__F1 Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling DKK1 APC NOTUM GSK3B LRP5 LRP6 SFRP1 CTNNB1 PMC7987655__F1 Tourette Syndrome Risk Genes Regulate Mitochondrial Dynamics, Structure, and Function SHANK3 CBLN2 PMC9496903__F7 ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK- and NO-Mediated Mechanism LANCL1 SIRT1 PMC5731985__F2 Mesenchymal stem cells in idiopathic pulmonary fibrosis MSC CXCR4 CXCL8 CTNNB1 PMC8059835__F8 Hippo signaling pathway in podocytes after GSK3B knockdown LATS1 FAT4 RASSF6 SMAD2 AJUBA NF2 PMC7462725__F2 Pathophysiological processes that drive cyst formation and growth in renal tubular epithelial cells of the collecting duct in ADPKD and the mechanism of action of vasopressin V2 receptor antagonists and SST analogues TSC2 TSC1 CFTR MTOR PMC3047474__F1 Architecture of intestinal TD and TI IgA responses CD40 TSLP PIGR PMC3047474__F2 Innate IgA-inducing signaling pathways IRAK1 TRAF6 TRAF2 IRAK4 AID RUNX3 MYD88 PMC11931165__F8 Osteogenic differentiation of GLP-1RA on BMSCs APC LRP5 SP7 RUNX2 CTNNB1 PMC11036006__F4 Diagram of “component-target-pathway” STAT3 HPSE MMP12 EGFR HTR2A AKR1B1 NOX4 HTR2B HTR6 DRD1 HTR1B CASP6 DRD2 ADRA2B ROCK1 PRKCA MMP2 IL2 APP HEL-S-11 ELANE PDE4D KDR ABCB1 CDC2 ACHE CASP8 CASP2 TRPV1 PDE5A PTGS2 VEGFA TNF FGF2 RORC ADRA2C EDNRA XDH CA9 PMC6177612__F3 Metabolic pathways of arachidonic acid COX1 PMC9290242__F3 Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management MTHFD2 MTHFD1 GLS HEL-S-51e DHODH PMC8515898__F1 Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Breast Cancer GSDMD NLRP3 PMC3118759__F5 Alteration to activity of the Akt/GSK3B signalling pathway can explain a number of the changes observed in microarray analysis of flies expressing rCAG, rCUG and rAUUCU repeats in the nervous system ATXN3 NGF ATXN1 GSK3B BDNF HTT PMC4615895__F6 The model for effect of miR-214 on osteoclastogenesis PTEN PDK2 PMC3353888__F1 Adrenergic Alpha-1 Pathway Is Associated with Hypertension among Nigerians in a Pathway-focused Analysis TH ADRA1B PNMT ADRA1A DBH POMC GNA11 DDC PMC4139891__F1 In renal cancer cells, stem cell factor (SCF) binding to the c-Kit receptor (c-KitR) induces several signal transduction pathways that lead to its proliferation, invasion, survival, and angiogenesis STAT3 NEDD8 FYN PTEN LYN MTOR SHE RAC1 OTP PMC4214862__F1 PI3K/AKT/mT0R signaling pathway TSC2 BAD RICTOR TSC1 PTEN MDM2 MTOR CCND1 ELF3 EIF4E PMC5436942__F4 A) IPA analysis suggests the involvement of signaling by ITAMs (immunoreceptor tyrosine-based activation motifs) in the FcGR pathway at 24h ACTR2 PXN c-fgr PIK3R2 PMC6283278__F1 Mitochondrial quality control mechanisms as molecular targets in cardiac ageing TFAM PINK1 FIS1 OPA1 MFN1 MFN2 NFE2L2 NRF1 PMC3397862__F7 Schematic representation for the up-regulating mechanism of NSC proliferation by modulating Notch signaling with Lewis X-containing glycans in NSCs FUT9 NUMB PAX6 NOTCH1 HES5 PMC6283278__F2 Mitochondrial quality control mechanisms as molecular targets in cardiac ageing TF TBK1 CGAS PINK1 FIS1 OPA1 MFN1 TLR9 TFAM FOXO1 FOXO3A MEN1 F3 MFN2 NFE2L2 NRF1 SIRT1 PMC5489563__F1 Action of thioester-containing proteins (TEPs) in mammals and mosquitoes HEL-S-62p C1S VTN TEP1 PMC6283278__F3 Mitochondrial quality control mechanisms as molecular targets in cardiac ageing RHEB IGF1 ULK1 TFEB PMC9032523__F1 COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3? NNMT NRK AOX1 NAPRT HEL-S-90n KYNU KMO NAMPT PMC6545170__F2 Wnt signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC9032523__F3 COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3? NNMT AOX1 NMNAT1 NAMPT NMNAT2 HEL-S-61p NMNAT3 PMC2999349__F3 Location of 2,4DNT impacted genes in the pathway association network PPP2R2B PLCB1 PTPRG PMC6695471__F1 Transcriptional regulation of carotenoid biosynthesis pathway (CBP) genes in photosynthetic tissues RFWD2 PIF1 DDB1 DET1 PMC2790753__F1 Microarray data for the genes in the pathway coined from the central genes in the KEGG pathways ‘insulin signaling pathway’ and ‘adipocytokine signaling pathway’ STAT3 PPARG TNFRSF1B LEP TRADD SLC2A4 CD36 TNFRSF1A FACL4 PRKAG2 FLOT2 SOCS3 PCK1 IKBKG ADRB3 PGC CPT2 RXRB EXOC7 ACSL5 ADIPOR1 ADIPOR2 LEPR FASN FLOT1 TNF CBL ACSL1 FOXO1 PFKP PRKAG1 RELA IKBKB RXRA NFKBIA JAK1 PFKL CPT1A TRAF2 NFKBIB PMC2724975__F6 Illustrating expansion results with ambiguity networks SELL ME1 SKA1 PMC3759924__F2 Lin28/let-7 regulatory axis CCND3 DGCR8 RICTOR HMGA2 MSI1 INSR TUT7 TUT4 DROSHA CCND1 CDK4 PMC9031400__F3 Tumor Microenvironment in Glioma Invasion STAT3 GDNF IL6 PMC11085166__F2 Keap1-Nrf2 signalling pathway for gene expression control KEAP1 NQO1 PON1 MPO PMC5061804__F1 Cellular signalling upstream and downstream of mammalian target of rapamycin (mTOR) complexes RPS6 EIF4B ULK1 GSK3B PTEN IGF1R MTOR DEPTOR ATG101 RHEB TSC2 TSC1 FOXO1 FOXO3A F3 PMC8526643__F2 What signals the glyoxalase pathway in plants? RAB18 HEL70 ME1 PMC4143103__F2 Canonical and noncanonical TGFB signaling TGFBR2 SMAD2 SMAD4 ARHA SKI TGFBR1 PMC3372091__F3 Mechanisms underlying the biological effects of polyphenols KEAP1 IL16 BDNF PMC7365993__F2 RAS-RAF pathway in relation to miR-31 and RASA1 EGFR GRB2 FOS PMC6493850__F2 Putative mechanisms underlying the neuroprotective effects of TGF‐B1 against AB‐induced neurodegeneration DKK1 GSK3B LRP5 LRP6 CTNNB1 PMC2679364__F6 OVARIAN CANCER BRAF KRAS PMC12249743__F5 Representation of epidermal human cell infection by SARS-CoV-2 and antiviral mechanisms TBK1 CGAS STAT2 PMC6262606__F1 Nuclear factor-kappa B signaling pathway CD40 LTBR BCR RELA RELB PMC3474261__F1 MTORC1 signaling and genetic mutations at specific sites in the pathway RHEB TSC2 TSC1 SOX2 MTOR EIF4E PMC4890987__F14 Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells MAX ID2 MAPKAPK2 TAOK3 DDIT3 TLR9 RPS6KA5 TRAF6 MAP2K3 FOS MYD88 PMC3403683__F1 T cell receptor (TCR)-mediated signalling pathway ZAP70 PALM FYN LAT APC LCK PMC5905132__F2 Adversarial functional module (AFM) pairs AP2M1 AP2S1 TAX1BP3 RHPN2 CBL AP2A1 RHO CLTB RTKN PMC4890987__F13 Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells CTCF CCR7 SMAD4 PKIA LRRFIP2 ATF4 ABLIM1 LEF1 PMC6352437__F8 Schematic diagram on the molecular mechanism of the anti-adipogenic effect of 10-HDA in 3 T3-L1 preadipocytes LPL TG EBP FABP4 PMC4890987__F10 Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells BTG3 JUN FLNB CRKL ZNF274 G0S2 MAP2K3 FOS CDK4 PMC11790572__F1 Shared immunopathologic mechanisms of the atopic march IL25 TSLP TGFB1 IL33 PMC3218055__F3 Proteomic Signatures of Human Oral Epithelial Cells in HIV-Infected Subjects AHSG HEL-S-99n LIMA1 EZR HEL113 DNAJC7 CRABP2 SNCG HEL-S-34 DKFZp761E1322 PMC7921839__F2 Diagram depicting the main proposed events in the autophagy pathway ATG10 ATR ATG14 ATG5 PMC11740111__F5 Analysis of the effects of TPBG-KD on signaling pathways using KEGG SIAH1 MCC APC RYK SHE DOCK2 BAMBI ALB RBX1 SOST INVS RNF43 CBY1 NOTUM NLK PMC11383167__F1 Biomarker validation in AGS SIGLEC1 STAT1 STAT2 IRF9 IFI27 RSAD2 ISG15 PMC9688631__F3 Molecular Biomarkers of Malignant Transformation in Head and Neck Dysplasia ATR CDK6 CDK2 ATM MDM2 CDK4 PMC5341791__F3 Signaling pathways triggered by GDNF activation of the RET transmembrane receptor ETV5 GDNF BCL6B GRB2 SRC FOS RET PMC3380091__F3 Endometrial androgen target gene set CCKBR BAD TRH SHCBP1 HIF1A MAOA PMC7322088__F7 Enhancing tumor growth due to the Hippo pathway being interrupted by LATS2 O-GlcNAcylation OGT LATS2 NF2 PMC6242950__F3 Caspase-dependent apoptosis pathways in myofibroblasts BAX BAD FAS BCL2 PTEN SMPD1 RHO FADD PMC3654583__F1 The RIG-I/MAVS signaling pathway in cancer cell-selective apoptosis MAVS IRF1 CXCL10 PMC3113675__F7 Arginine methylation of G3BP1 regulates both Ctnnb1 mRNA and canonical Wnt/Beta-catenin signaling PRMT1 WNT3A DVL3 CTNNB1 PMC4214635__F2 De Novo Mutations in Moderate or Severe Intellectual Disability GRIN2B SETBP1 STAG1 TCF4 YY1 FLNA CTNNB1 SHANK3 KCNQ3 PPP2R2B KCNQ2 HEL-S-80p DYNC1H1 GRIN1 VPS4A PPP2R5D RYR2 TUBA1A CACNA1A NACC1 CACNG2 TRIO EGR1 CDKL5 BCORL1 MYH10 ASH1L WDR33 SMC1A KIF1A SET SYNGAP1 ARD1A PDHA1 SCN2A ALG13 DDX3X CAMK2G SPTAN1 PMC9133251__F6 Modified natriuretic peptides and their potential roles in cancer treatment GC SI CNP PMC7755097__F3 Retinoic acid signaling pathway is identified by topographic transcriptomic analysis of NAcSh TBX2 DPPA3 MGST3 GATA2 MCL1 PPM1G CHL1 PHLDA1 MAPK8 NEUROD6 LAMB1 RPL5 COL4A2 HEL-S-1 GAD2 CSNK1A1 HES1 HEL-S-44 CD6 CEBPE P2RX7 SLC26A3 MMP7 PDYN WNT7B GRM2 COL2A1 SIAT4C REC8 BTG2 CFP CRABP2 RXRA GRB2 UBE3A ABI3BP NR1C2 XBP1 MEF2C PRKCH CTNNB1 RARA NR1B3 NME2 UBE2D3 ISG15 MAP2K3 ABLIM1 CYP26B1 PTPRU LTC4S SETD5 JCHAIN CAPN7 KIF1B PPP2R5B YBX1 DDX10 PRNP TERF1 SLC25A15 PTP4A3 CD34 HOXB6 LYPD1 CREG1 HSF4 HIVEP3 TSPAN14 FABP5 FUBP3 KANSL3 SHKBP1 CRABP1 NAV2 NFATC3 ASNS SYN1 PMC6947386__F2 Cellular calcium [Ca2+] homeostasis and signaling: Organelles and molecules that are involved in Ca2+ pathways ORAI1 STIM1 MCU TRPC5 TRPC3 PMC4997072__F2 TLR signal transduction pathways TBK1 TIRAP TLR3 TLR4 CD14 IRF3 TRAF3 TRAF6 LBP MYD88 PMC4406223__F4 Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation CTRL RS1 IRS1 PMC8800007__F3 Targeted Cancer Therapy Based on Acetylation and Deacetylation of Key Proteins Involved in Double-Strand Break Repair BAX NAT10 MORC2 SIRT1 PARP1 PMC8421919__F2 Bioinformatical identification of key genes regulated by IGF2BP2-mediated RNA N6-methyladenosine and prediction of prognosis in hepatocellular carcinoma HSPG2 SOCS3 CCNA2 CSTB MAPK3 FOXM1 TACC3 HJURP CDCA5 SPC24 GGH SPON2 CHAF1A NHP2 TUBB IGF2 HRAS MCM7 CDCA3 HMGA1 GINS2 MCM3 EMC3 MGAM HCTP4 HMGB2 YWHAZ PMC6876670__F2 Canonical WNT/Beta-catenin pathway: “on” and “off” states DKK1 APC GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC6876670__F3 WNT/Beta-catenin, TGFB1, PI3K-AKT, SMAD, and PPARG pathways DKK1 APC LRP5 LRP6 PTEN CCND1 CTNNB1 PMC7878545__F6 Summary of Treg-of-B (P) cell generation and their molecular mechanisms in alleviation of asthmatic inflammation BAX AHR LAG3 PMC7476662__F4 Predicted genes in the MAPK signaling pathway targeted by downregulated serum miRNAs (miRNAs) in BD, sarcoidosis, and VKH TAOK1 FGF13 FAS FGF14 PPP5C BRAF CACNB4 RRAS ATF2 KRAS MEF2C TGFBR1 PMC2953449__F3 Different effects of gut- and brain-derived serotonin on the osteoblast HTR1B ADRB2 ATF4 PMC6876670__F6 Canonical WNT/Beta-catenin pathway, Warburg glycolysis, and cancer HEL-S-133P DKK1 APC GSK3B LRP5 LRP6 PTEN CTNNB1 PMC3061549__F1 The classical and alternative selection pathways in the thymus FOXP3 CD8A PMC3175541__F7 NK2 homeobox 1 (NKX2-1)–Sam Pointed Domain Ets-like Factor (SPDEF)–associated gene network analyzed using Ingenuity Pathway Analysis ITGA7 MMP12 ORM1 SPDEF AREG ORM2 CCKAR SCIN IFNG AGR2 CLCA1 ICOS NKX2-1 CREBBP TLN1 PMC8950345__F1 Fanconi Anemia Pathway in Colorectal Cancer: A Novel Opportunity for Diagnosis, Prognosis and Therapy FANCE FANCD2 ID2 MRE11A BRCA2 FANCM FAAP24 PALB2 PARP1 PMC8950345__F2 Fanconi Anemia Pathway in Colorectal Cancer: A Novel Opportunity for Diagnosis, Prognosis and Therapy FANCD2 MSH6 RAD51C RAD51 MSH2 PMS2 FANCM PMC5851908__F1 Regulatory network for p42.3 involvement in tumor cell apoptosis (red pathway indicates the maximally possible acting pathway) BAX S100A4 HEL-S-43 BAD PAK1 ROCK1 S100A2 TRAF2 S100B PMC4196247__F6 Role of long-chain and very-long-chain polyunsaturated fatty acids in macular degenerations and dystrophies ELOVL4 ELOVL3 ELOVL2 ELOVL1 ELOVL5 PMC3832246__F1 TNFR1 signaling of cell survival/proinflammatory and apoptosis pathways. Upon TNF receptor activation, complexes I (survival pathway) and II (apoptosis) are formed SHARPIN TRADD TNFAIP3 TRAF5 MMP3 VCAM1 CXCL10 TRAF6 TNF TRAF2 FADD PMC5851908__F3 Regulatory network for p42.3 involvement in colorectal cancer cell apoptosis (the red pathway indicates the possible acting pathway for p42.3 involvement in cell apoptosis) BAX CASP9 DCC BAD APC WWOX CASP3 PTEN MDM2 CTNNB1 PMC3073571__F8 Cone-specific Visual Cycle RPE LRAT RPE65 PMC6950849__F1 Central role of TORC1 signalling pathway and importance of wild alleles for yeast nitrogen consumption GIN1 GEN1 EIF2A PMC2916406__F7 New model for a novel role of p38 MAPK in the DNA damage response in cancer cells CDC2 ATR ATM PMC6053314__F5 NFKB Activation in primary CNS lymphoma STAT3 SYK CD79B CD79A PIM2 CXCL13 PIM1 BCL2A1 CARD11 IRAK1 MTOR IRF4 TRAF6 MYD88 BTK BCL10 BCR CXCR5 BCL2 RGS13 JAK1 PMC6943912__F1 Immunogenetic effects of low dose (CEM43 30) magnetic nanoparticle hyperthermia and radiation in melanoma cells CXCR3 CCL22 CCL3 CCR2 CCR3 CCL2 CCL23 CCL21 CCR6 CCL7 CCR7 XCL2 CXCR6 CCL16 CCL11 CXCL16 CCL14 CCL13 CXCL17 CCL24 CCL19 CCL25 CCR4 CCL4 CXCR4 PMC12132251__F4 Functional integrative gene-based enrichment for genes annotated to the meta-analyzed hypo- and hyper-methylated CpGs consistent across all three studies and across all LF phenotypes: GACRS, CAMP and VDAART BAGE KRT14 MYADM PC CAPN12 ZFP2 TTC21A MPO PMC6024579__F2 Hepatic cell death pathway and liver injury in response to high fat diet exposure FAS CASP8 CASP3 TNF IL1B FADD PMC5930509__F9 Proposed hypothetical model depicting the involvement of miR-424/503 cluster in the Activin signalling pathway by targeting SMAD7 SMAD2 SMAD4 PMC9701047__F6 Comparative transcriptomic analysis provides insights into the molecular basis underlying pre-harvest sprouting in rice HEL-S-162eP CS PMC2655379__F8 Potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle PDK4 IGF1 PDC IRS1 PMC10221877__F8 Response of DA metabolic pathway to Cd stress in duckweed TH PNMT DBH PMC6745137__F6 Mechanisms of Yi Guan Jian Decoction in Chronic Hepatitis B Patients with Liver Fibrosis FCN2 ARHGAP1 KIF13B CYTH2 CCL18 BRPF1 CCL3 RNF4 PBX1 RXRG QSCN6 VAMP8 INHBA CSNK1D DUSP4 DVL2 TNF FOS SKI HGS EIF4G1 OPRD1 CYP2C9 CENPB THPO PRKAR1B MEA1 SMG5 POFUT2 SMN1 FBXL19 TREM2 IGF2R DPF2 HSF1 LDLR SRXN1 IFNA1 TFDP2 IL1B LNX1 JUN FASN SEC24C STS USP30 DPP9 PLK3 RELA PHF5A MBD3 OCRL PMC7078051__F4 Iron homeostasis disruption in HLRCC FTH1 FOXM1 RBX1 FTL KEAP1 VHL PMC4049860__F3 CCM1 and the second life of proteins in adhesion complexes APC LRP5 LRP6 CTNNB1 PMC3973244__F7 Role of RNase L and TLR3 activation during inflammation in insulin response of obese people's myotubes TLR3 TLR4 RNASEL IRF3 SOCS3 IRS1 MYD88 PMC7815887__F2 T2 inflammatory pathway (eosinophilic COPD and asthma) and the target sites for anti-IL-5 agents IL25 TSLP IL33 IL5RA GATA3 PMC6210917__F7 Tsc3 regulates the balance between canonical and noncanonical SPLs by promoting l-alanine incorporation into the SPL de novo synthesis pathway TH ORM1 ORM2 PMC8011202__F1 Insulin and pharmacological agents on endothelial insulin signaling DPP4 GIP GRB2 PMC5568011__F7 MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis SP1 INSR PTPN1 IRS1 PMC2725943__F7 A model of mammalian Hh signaling SPOP SUFU PTCH1 SMO GLI3 PMC9547905__F4 Hybrid network of genetic associations revealed by gene-based association studies and significant partial correlations of detected sphingomyelins, SGPL1 SPHK2 SPTLC3 SGPP1 CERS2 PMC4009339__F3 Gene network of T-ALL (early response) derived from GeneMANIA (a) and STRING (b) (NR3C1 interaction is highlighted) POR FKBP5 FBXL17 FKBP4 NASP JUN KDM5A FOS NR3C1 TRIM23 PMC3678415__F2 HDL biogenesis ABCG1 ABCA1 PMC3374768__F11 Activation of EGFR/ERBB2 via Pathways Involving ERK1/2, P38 MAPK, AKT and FOXO Enhances Recovery of Diabetic Hearts from Ischemia-Reperfusion Injury EGF EGFR ERBB2 PMC6822566__F1 Complement cascade and its diverse effects of on alloimmunity and inflammation CD59 FH HEL-S-62p C2 C1S CD46 PMC3678415__F1 HDL metabolic pathways and current drugs under development TG ABCG8 ABCG5 LDLR PLTP ABCA1 PMC11820857__F10 In darkness (A), CRY1 remains in its inactive form and is unable to suppress BR signaling because it does not interact with dephosphorylated BES1 RFWD2 CRY1 PMC9589344__F1 Targeting aldehyde dehydrogenase for prostate cancer therapies RARA HEL-S-53e RARB DLL4 SMAD2 GSK3B SMAD4 SIRT2 CCND1 CTNNB1 PMC3221387__F1 Impact of miR-215 on cell proliferation, cell cycle, chemoresistance, and EMT DTL DHFR MCM3 ZEB2 PMC4061808__F4 Exercise activates a wide variety of intracellular signal transduction pathways to promote neurogenesis of granule cells from neuroprogenitors in the dentate gyrus PROX1 NEUROD1 APC SOX2 PMC8405297__F6 Biological Activity, Hepatotoxicity, and Structure-Activity Relationship of Kavalactones and Flavokavins, the Two Main Bioactive Components in Kava (Piper methysticum) BAX NLRC3 MMP2 MMP9 MTOR CCND1 CDK4 PMC10931536__F4 Selected epigenetic changes and host-virus interactions perpetrated by EBV nuclear antigens and latent membrane proteins STAT3 ATF3 CD79B SYK CD79A BTK BCR PLCG2 RELA BLNK TRAF6 PMC10525526__F1 Phenotype Alterations in the Cecal Ecosystem Involved in the Asymptomatic Intestinal Persistence of Paratyphoid Salmonella in Chickens CRK BAD FRS2 ARHA GRB2 SHE TRAF6 PMC7842006__F3 Ingenuity Pathway Analysis (IPA)-identified immune related gene networks with score > 20 IFNG WNK2 STAB2 LDB2 BCR CMTM8 NAMPT LILRA4 PMC12145526__F2 The BMP pathway in the musculoskeletal system SMAD9 SMAD1 DKFZp781O1323 COPS5 SMAD6 SMAD4 MTOR USP9X STUB1 SMURF1 USP15 NEDD4 USP4 RNF111 PMC7783313__F5 Macrophage and bone remodeling related diseases RIPK3 CCL18 PMC7490109__F1 Possible mechanism of SARS-CoV-2 mediated innate immune response at the lung alveolar cell TLR8 TLR7 CCL8 TRAF6 CCL2 ACE2 IL1B PMC12145526__F3 BMP signaling in OP FRZB ANGPTL4 COL1A1 RUNX1 DKK1 MSC TWIST2 ATF4 CCL2 RUNX2 AXIN2 PMC3338606__F6 Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NFKB Signalling MAFA TLR4 MYD88 PMC12154924__F2 Recent Advances in Molecular Research and Treatment for Melanoma in Asian Populations ROS1 BRAF KIT MTOR PMC9167935__F9 MSC-ACE2 Ameliorates Streptococcus uberis-Induced Inflammatory Injury in Mammary Epithelial Cells by Upregulating the IL-10/STAT3/SOCS3 Pathway STAT3 GSDMD NLRP3 SOCS3 PMC12145526__F7 Crosstalk of the BMP with other signaling pathways in musculoskeletal disorders (Created with BioRender SMAD1 DKFZp781O1323 RUNX1 SOX9 SMAD2 APC MAPKAPK2 GSK3B SMAD6 SMAD4 SMURF2 CTNNB1 PMC9372960__F1 Deucravacitinib for the Treatment of Psoriatic Disease IL19 JAK3 EPO TPO JAK1 TYK2 PMC3171509__F1 This figure illustrates the core TSC-mTor pathway, as discussed in the text TSC2 TSC1 PTEN MTOR PMC11006730__F4 Acid-sensing ion channels and downstream signalling in cancer cells: is there a mechanistic link? RIPK3 RIPK1 ARHA PMC2742584__F7 Interaction networks of As sensitivity in yeast RFC4 RAD50 RFC2 MRE11A RPA4 WDHD1 RFC3 PMC9381515__F3 Mechanism of necroptosis leads to airflow limitation in COPD RIPK3 HMGB1 MLKL PMC8189177__F1 FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes LPL TG BMP4 PDGFRA MSC MYF5 FGF10 FGFR2 PMC4130217__F4 Protomural role of tumor-associated macrophages (TAM) EGF CCL18 MIF CTNNB1 PMC8189177__F2 FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes LIF SFTPC FGF10 PMC9381515__F1 Main detection methods of necroptosis RIPK3 MLKL RIPK1 PMC11544529__F2 DUBs in the PI3K/AKT, NFKB and MYC pathways in urologic cancers USP43 EGFR USP22 UCHL5 PTEN IGF1R MTOR TNF CYLD USP16 PMC11544529__F3 DUBs in the RAS/RAF/MEK/ERK, p53 and TGFB pathways in urologic cancers USP28 USP19 SMAD2 SMAD4 MDM2 GRB2 USP9X USP26 PMC11544529__F4 DUBs in the Wnt/Beta-catenin and Hippo pathways in urologic cancers LATS1 USP25 LATS2 MINDY1 USP34 APC CYLD CTNNB1 PMC7415419__F5 Models for mammalian target of rapamycin (mTOR) behaviors on autophagic signaling pathway activation during osteoclast differentiation and formation RHEB TSC2 TSC1 ULK1 MTOR PMC4807884__F1 Regulation of SMN2 gene expression in SMA PRLR SMN1 PMC7415419__F6 Autophagy regulatory signaling pathways are involved in the pathological process of osteoarthritis/rheumatoid arthritis (OA/RA) RHEB SIRT3 ULK1 MTOR SIRT1 PMC5401738__F1 IL-12 activation of JAK-STAT pathway STAT4 TYK2 PMC10296674__F3 Canonical pathways derived using the IPA tool SHARPIN BAD SHC1 BCL2 PTEN PREX2 CCND1 PMC3976829__F4 Schematic illustrations for potential signaling pathway of IMF deposition in skeletal muscles regulated by GHR and SOCS3 LPL IGF2BP3 LEPR SOCS3 GHR WNT10A PMC11612504__F2 Role and mechanism of the EGFR/MET-mediated signaling pathway in cancer cells EGF BAD HGF EGFR GSK3B PTEN MTOR PMC6664158__F1 Proposed molecular mechanisms of PAX3 in glioma pathogenesis and progression PAX3 MMP7 GFAP GSK3B CCND1 CTNNB1 PMC4339542__F4A Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells TF STAT3 JAK1 PMC3677161__F5 Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease TCIRG1 MYB SYK CLIC1 PARVG IFI30 RBM47 ADAM28 PTPRC CTSS MYO1F MYO1G DOCK2 DOK1 TYROBP CD74 PTGS1 LAT2 HEL-S-43 APOC1 SERPINA1 IL10RA SLC7A7 CMTM7 FPR1 AIF1 CMTM6 IL10RB TNFRSF1B PYCARD GRN GPX1 TGFBR1 CSF3R HLA-DRA LILRA2 CD33 IL13RA1 IL18 MFNG CSTA HLA-DMB ARHGAP30 BLNK PTPN6 SLC15A3 HLA-DMA RUNX1 FCER1G PBR LYN REL PMC10374212__F3 NLRP3: a new therapeutic target in alcoholic liver disease GSDMD CYP2E1 IL1B MYD88 PMC3133616__F4 Functional network of ion channels in T lymphocytes TG TRPM7 ORAI1 STIM1 APC PMC8397987__F3 Fructose and Mannose in Inborn Errors of Metabolism and Cancer KHK ALDOB FBP1 PMC7140408__F6 Reductive schematic of the proposed VPA induction pathway in the treatment of ADSCs toward neural differentiation SCN3A SLC25A24 APOA4 GFAP EGFR FGF21 SOCS5 FGFR3 KCNG4 KCNT2 NETO2 PMC3169181__F2 Crosstalk between host autophagy and viruses ATG3 ATG12 MTOR ATG5 PMC8298499__F6 Untargeted Metabolomic Profiling of Liver in a Chronic Intermittent Hypoxia Mouse Model TF SLC3A2 STEAP3 GPX4 PRNP CP ADA PMC7826840__F4A Analysis of the Immune Responses in the Ileum of Gnotobiotic Pigs Infected with the Recombinant GII.p12_GII.3 Human Norovirus by mRNA Sequencing CD40 ICOS CD80 IL24 VAV1 GRB2 GATA3 PMC3921899__F1 Lipid signals and insulin resistance AGPAT5 HMFN0839 DGAT1 GPAT4 GPAT2 AGPAT3 AGPAT4 MTOR LPA ACSL1 RICTOR GSK3A FOXO1 DGAT2 PC PMC7897836__F2 Developmental Regulation of GFAP Expression PRMT1 CNTF GFAP SIN3A OSM ERBB4 LIF BMP2 NFIA PMC8929449__F5 Smoking-induced changes in buccal mucosal gene expression QK3 CCND2 RPS6KB1 SMAD2 BMP2 CLDN3 ITGAV PMC8929449__F9 Smoking-induced changes in buccal mucosal gene expression STK4 MAP3K14 IKBKG KCNA3 GTF2F1 DLGAP1 RIPK2 CTDSPL CCNE1 SHANK1 INSR PHLPP2 SMO EPHA3 CSNK1A1 CRP TIMP3 CFH DYRK1B NTRK2 FOS RPS6KB1 POLDIP3 PSEN2 BMP2 RPS6KA5 PMC10036590__F4 Targeting CLDN18.2 in cancers of the gastrointestinal tract: New drugs and new indications NRG1 CLDN18 MTOR PMC4942188__F1 Targeting lipid metabolism for the treatment of Anaplastic Thyroid Carcinoma RHEB EGF TSC2 TSC1 HMGCR CD36 SCD FASN LDLR MTOR PMC8834417__F1 Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives HK2 HIF1A MTOR PMC3470584__F2 Suppressed RNA-Polymerase 1 Pathway Is Associated with Benign Multiple Sclerosis TBX2 TRAF3IP2 EPHA2 FSTL1 DNCL1 FHL2 MYC TRAF6 COX17 IFNG NID2 BICD2 DUSP26 RAD17 NOL3 APOL1 GNL3L UBB SMARCA4 CAST ASXL1 RPL35A HPGD EEF2 DUSP10 NRCAM RRN3 CD27 IKBKE SPHK1 THRAP3 POLR1D DGKA MED14 ITGA6 ATM CAMK4 TAP2 POLRMT GTPBP4 ACHE RPS6 AFF4 NFATC1 LRPPRC CD44 TFPI2 RUNX1 CHST12 PMC9461676__F3 Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies PDGFD VEGFC IL33 FAP VEGFA IL6R PMC9461676__F4 Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies TH FAS GCA FOXP3 LAIR2 PMC5714444__F1 Intracellular sugar-responsive gene regulatory network SIK3 SIRT1 PMC5714444__F2 The role of the HBP and protein O-linked GlcNAc conjugation in the regulation of Drosophila physiology OGA OGT PGM3 PMC7826431__F3 Open questions regarding NB–MSC interactions STAT3 IGF1R CCL5 NOTCH2 PMC3932028__F5 Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells RAPGEF2 RAPGEF4 PMC8582349__F3 MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets RAN AGO2 DROSHA PMC6985587__F2 Predicted interactions among apoplastic proteins and signaling molecules in resurrection plants during dehydration PMC4222910__F6 In Vitro, In Silico and In Vivo Studies of Ursolic Acid as an Anti-Filarial Agent MAP3K8 TIRAP MAP2K6 CD36 MAL CD14 IRAK1 MAP2K3 CREB1 PMC9461676__F5 Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies STAT3 OSM CXCL5 CXCL1 PMC8107678__F1 Toll-Like Receptors Gene Polymorphisms in Autoimmune Disease TIRAP TRAF6 MYD88 PMC8431455__F5 Hexokinase and Hexose Transporters in Preferential Use of Glucose over Fructose and Downstream Metabolic Pathways in the Yeast Yarrowia lipolytica HEL60 tal-1 FBP1 MDH2 HEL-S-26 GPD1 PMC7955431__F1 Coronavirus Disease 2019–Associated Thrombosis and Coagulopathy: Review of the Pathophysiological Characteristics and Implications for Antithrombotic Management TMPRSS2 STOM IL18 PLG ACE2 PMC9147390__F9 Evaluation of TILI-2 as an Anti-Tyrosinase, Anti-Oxidative Agent and Its Role in Preventing Melanogenesis Using a Proteomics Approach PAX3 CASP9 PIK3CA ACVR2A DKFZp781O1323 RAF1 PIK3CD TYRP1 ABCB10 MAPK3 BMP6 SMURF1 MAP3K7IP1 PAF1 MAP3K7 MAPK12 SMURF2 PMC4794363__F6 SGEF is Regulated via TWEAK/Fn14/NFKB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide ARHG BRCA1 TRAF2 PMC2921475__F1 Cord Blood Genomic Analysis Highlights the Role of Redox Balance UCP2 HEL-S-2a PMC12092457__F1 SPC25 is an important part of the NDC80 centromere complex SPC25 NUF2 KNTC2 PMC23119__F3 Roles of INH-induced genes in the context of a proposed pathway for mycolic acid biosynthesis CMA1 INHA CS PMC6794807__F5 Protein-Protein interaction network and 5 identified sub-networks of TTR-mRNAs HTRA2 MCAT MADD ADAR ADM GEM COCH GLA PC4 POR PAN2 CLU HAL RELA HEL-S-69p MRPS27 ASNS CROCC CNTRL WDR8 PMC8775450__F2 Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments OGG1 TFAM SIRT3 PINK1 FOXO3A ATF4 SIRT2 NRF1 SIRT1 ADA PMC8359037__F2 Systematic summary of survival and death signalling during the life of hair follicle stem cells DKK1 APC CTNNB1 PMC7590459__F1 Simplified diagram of the KP HEL-S-90n IDO1 KYNU KMO PMC6539070__F2 Molecular mechanisms of adipogenesis BMP4 ZNF423 CTNNB1 PMC8359037__F3 Systematic summary of survival and death signalling during the life of hair follicle stem cells SUFU SHH SMO PMC4064254__F2 An atlas of genetic influences on human blood metabolites ABCC1 PAOX FADS1 SLC22A4 LIPC ADHFE1 ALOX12 PAH OPLAH TYMP CRAT SCD APOE NUBP2 DDC SCAPER AGXT SLC6A20 PHGDH ANKH ALX3 SH2B3 MGAM HEL-S-61p GCKR GLS2 PRODH GMPR PSPH PM20D2 PMC3001953__F2 EGFR-mutated lung cancer: a paradigm of molecular oncology DUSP8 DUSP4 GRB2 MTOR CCND1 PMC4937026__F4 Activation of STAT3 in KSHV-infected endothelial cells STAT3 CD59 CD55 SH3BGR PMC8724243__F1 Progress on the Function and Application of Thymosin B4 BAX SMAD2 LEF1 CTNNB1 TGFBR1 PMC6794807__F9 Five functional lncRNA-mRNA trans regulatory network CHD1L ACD CNOT2 ASNS HEL-S-51e PMC8044749__F1 Proposed immunopathological roles of circulating histones in sepsis TF COX2 IL16 PMC9010858__F2 Treatment of Retinoblastoma: What Is the Latest and What Is the Future CD2 PMC11024162__F9 TGFB signaling pathway SMAD2 SMAD4 PMC3460040__F8 Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with Sorafenib RAF1 ORAI1 STIM1 BRAF PMC3773516__F6 MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways TBR1 DLX1 DLX2 ZEB2 CREB1 SOX5 MEF2C FMR1 ARX PMC3601842__F1 mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development RHEB TSC2 RICTOR IGF1 PTEN MTOR DEPTOR PMC12018393__F4 Tamoxifen metabolic pathway CYP2C9 CYP3A4 PMC8359037__F7 Systematic summary of survival and death signalling during the life of hair follicle stem cells BAX CASP9 CASP3 MDM2 FADD PMC12018393__F8 Fulvestrant predominant metabolic pathway UGT1A4 UGT1A3 SULT1A1 UGT1A8 PMC9448512__F1 Canonical and non-canonical AhR signaling pathways KLF6 AHR SLC7A5 CYP1B1 CYP1A1 PMC3670316__F7 Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis RIPPLY2 MESP2 WNT3A TBX6 PMC12018393__F6 Toremifene metabolic pathway CYP2C9 CYP3A4 PMC4260983__F1 Sex hormone biosynthesis and degradation pathway UGT1A1 SRD5A2 HSD3B1 CYP1B1 CYP1A1 PMC12092457__F2 SPC25 can be used as a scaffolding platform to coordinate the assembly of the SPC25/RIOK1/MYH9 trimer complex, triggering RIOK1-mediated phosphorylation of MYH9 Ser1943 SPC25 MYH9 KNTC2 RIOK1 PMC5228523__F4 MicroRNA-gene interaction networks of the MAPK signaling pathway HEL-S-31 CCNI2 CACNA1C FAS MAP4K3 RAF1 E2F2 CRKL KRAS DUSP2 MAPK6 MAPK14 CRK MAPKAP1 CCNE1 BCR F3 CHUK MAP2K1 PMC7772402__F1 Schematic presentation of early steps of SARS-CoV-2 life cycle TMPRSS2 SI ACE2 PMC4728678__F2 Lipid rafts as platforms for cell signaling SRC CXCR4 FADD PMC125938__F8 An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype PROX1 XLKD1 CD34 PMC5138100__F6 New Insights into Protein Hydroxylation and Its Important Role in Human Diseases EPOR dik HUWE1 MAPK6 PMC4075164__F2 Multiple intracellular signal transduction pathways are activated by GH SRC GHR PMC4194224__F7 Expression of Suppressor of Cytokine Signaling-3 (SOCS3) and its role in neuronal death after complete spinal cord injury STAT3 BAX SOCS3 PMC7198187__F1 Immunomodulation in COVID-19 STAT3 STAT1 TIGIT STAT2 COX2 TLR4 IRF9 IRF4 CCL2 ACE2 MYD88 PMC4235760__F1 MICRORNAs IN ER STRESS: DIVERGENT ROLES IN CELL FATE DECISIONS CASP2 TXNIP ATF4 EIF2A PMC5968394__F2 PI3K/Akt signaling facilitates ROS detoxification and redox homeostasis SGK1 KEAP1 GSK3B PMC2785932__F3 Four pathways by which the EBV latent membrane protein 1 (LMP1) is thought to signal inside cells TRADD JAK3 TRAF1 ATF2 GCKR TRAF3 TRAF2 PMC2383880__F7 A logic-based diagram of signalling pathways central to macrophage activation FAS CASP4 NFKB2 RELA SOCS3 TNF LMNA PMC2383880__F1 Manual layout of Type II interferon signalling (IFNG) taken from the integrated pathway diagram (Figure 2) IFNG IL18 GAS1 PMC4914733__F7 Proposed signaling mechanisms mediated by Lipoxin A4 in preventing intestinal epithelium cells from intestine ischemia reperfusion (IIR) injury KEAP1 FABP2 DAO PMC6546329__F3 Intestinal luminal putrescine is produced by collective biosynthetic pathways of the commensal microbiome ASL OTC PMC3711139__F4 Preparation of Dihydrothieno- and Dihydrofuranopyrimidines BOC PMC10815168__F1 Schematic diagram depicting the miRNA signaling pathways activated by aldosterone through the MR WNK1 TIMP3 SGK1 ITSN2 ELAVL1 HSD11B2 PTEN TUG1 ITSN1 PMC6370674__F2 Pathway map of Notch signaling (A) and Th1 differentiation (B) in KEGG ACHE TH CLU STAT4 SET PMC6598836__F4 Essential metabolism and mitochondrial regulation on B cells (A) and Antibody-Secreting Cells (B) CD40 FAS BCR CD9 PMC7699985__F1 VEGFR-2 signaling and 4 types of anti-angiogenic agents VEGFA SRC PMC8779539__F1 Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer’s Disease and Long COVID PMC5568615__F2 COX-2/PGE2pathway in colitis-associated CRC COX1 CXCL1 PMC7335982__F6 Signaling pathways and deregulation of its modalities such as Stat3/mTor, Hedgehog, Notch and Wnt/-catenin cascade defined as a new therapeutic strategy in the prevention of cancer extension, especially CSCs growth behaviors modification () APC SMO CTNNB1 PMC9366743__F6 Beta-Carboline Alkaloids From the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-pulmonary Fibrosis Agent That Inhibits TGFB/Smad Signaling Pathway SMAD2 SMAD4 TGFBR1 PMC12039932__F5 Nanomaterial-based DDSs treat OA by targeting chondrocytes BAX WNT3A BCL2 PMC9288068__F4 Exploring immunotherapy in colorectal cancer CXCL9 CXCL11 TH STAT1 POLI CXCL10 PMC12039932__F3 Nanomaterial-based DDSs treat OA by targeting synoviocytes TRPA1 MMP3 MTOR TNF PMC3215775__F1 Molecular mechanisms through the Epidermal Growth Factor Receptor pathway EGF EGFR GRB2 PMC6487669__F16 De Novo Pyrimidine Biosynthetic Pathway Diagram CAD CTPS2 CMPK2 UMPS DHODH PMC12039932__F2 Nanomaterial-based DDSs treat OA by targeting macrophages CGAS TLR3 TRPV1 MTOR PMC8085542__F1 Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH FGF21 GSK3B GHRH GIP GCGR GHRHR FGF8A NR1C1 IGF1 CYP7A1 FGFR4 LDLR NR1A2 GHR GIPR PMC7105304__F10 Leptin-mediated MTP regulation through long- (ObRb) and short- (ObRa) forms of leptin receptors TF STAT3 PMC10749620__F2 NRF2 peptide with its seven Neh domains and their roles RBX1 KEAP1 RXRA MAF PMC10749620__F3 KEAP1-NRF2-ARE pathway RBX1 KEAP1 MAF PMC10749620__F4 KEAP1-NRF2 by P62 non-canonical pathway RBX1 KEAP1 PMC7823450__F1 Metabolic pathway of oxysterol sulfates CH25H CYP46A1 CYP27A1 PMC7823450__F2 Novel regulatory pathway of oxysterol sulfation BAD CYP27A1 PMC6341466__F1 Expanding the Clinical and Molecular Characteristics of PIGT-CDG, a Disorder of Glycosylphosphatidylinositol Anchors PIGP PIGC GPAA1 PIGH DPM2 PIGV PIGU PGAP1 PIGT PIGO PGAP2 PGAP3 PIGF PIGN PIGW PIGA PIGY PIGX PIGB PIGL HEL-S-5 PIGK PIGS PIGM PMC10948547__F1 Molecular mechanisms of TLR4 in osteoporosis development KDM4A HMGB1 CUL4A TLR4 RUNX2 S100B MYD88 PMC3273847__F1 Innate Immunity in the Host Defense Against intestinal Bacterial Pathogens TLR3 TLR4 NOD2 IRF3 IRF7 NOD1 TLR7 TRAF6 IL1B MYD88 PMC8391638__F2 Rho-Proteins and Downstream Pathways as Potential Targets in Sepsis and Septic Shock: What Have We Learned from Basic Research ARHA RHO PMC6398501__F8 An integrated model for ROS mediated clearance of VAP(P58S) aggregates via UPS MTOR VCP HEL-S-44 PMC4905335__F1 Mechanism of retention of BRCA1/BARD1 complexes at DNA double-strand break sites BARD1 MACROH2A1 BRCA1 RNF168 H2AX RNF8 PRDM2 ATM RIF1 MDC1 PMC6329923__F8 Proposed model of the mechanism of GALNT6-mediated regulation of proliferation and metastasis thought Beta-catenin /MUC1-C signaling in breast cancer APC GALNT6 CCND1 CTNNB1 PMC5104508__F1 Classical view of progressive linear cascades in the asymmetry-determining pathway SMAD1 SMAD2 SHH SMAD4 NODAL PITX2 FGF8 PMC7915278__F5 Selected network of 138 proteins that were found in a functional screen for proteins involved in the pathway in cancer (KEGG: hsa05200) PIK3CA PIK3R2 SMAD2 CYCS PIK3R1 SMAD4 MAPK8 SPI1 MAPK3 BCL2L1 RALA BCR PLCG2 PRKCA WNT4 HDAC2 RALBP1 CASP9 MSH6 MSH2 MSH3 CRKL DVL2 PIAS2 CRK RBX1 SOS2 LAMB3 BCL2 TRAF1 GRB2 CTNNA1 LAMA3 MAX CDC42 TGFB1 NFKB2 PML STK4 IGF1R MTOR LAMC1 ITGAV IKBKG TGFBR1 CTNNB1 TGFBR2 TPR PLCG1 RALB ITGA6 CTBP1 CHUK RXRB BIRC3 JUP FH TFG KIT MMP9 ARHA KRAS RAC1 CCDC6 ARAF CBL ITGB1 HEL-S-125m IKBKB CASP3 PIAS1 DVL3 CREBBP EP300 MAP2K1 TRAF2 PMC4979485__F1 LINP1 regulation and role in the NHEJ DNA-repair pathway H2AX EGFR ATM PMC7915278__F4 Functional networks of proteins involved in the following pathways: (A) B-cell receptor (BCR) signaling pathway (hsa04662), (B) cellular adhesion molecules (CAMs) pathway (hsa04514), (C) PPAR signaling pathway (hsa03320) PIK3CA RAF1 SOS1 CD72 RASGRP3 PIK3R2 PIK3R1 CD22 GSK3B SDC4 ACADM BCL10 ACOX3 NRAS SCD5 CYP27A1 APOC3 ACOX1 ACSL6 ACSL5 ICAM3 SELL VAV3 ITGB7 L1CAM MPZL1 CNTN1 DAPP1 SPN SOS2 VCAM1 HLA-A F11R HLA-DOB HLA-DPA1 HLA-DRA HLA-DMB CD19 KRAS RAC1 PECAM1 FABP5 DBI IKBKB NFKBIA LYN CPT1A CD40 CD79B SYK CD79A ACSL3 NFATC2 VAV2 HLA-DOA PIK3CD CLDN3 FACL4 PTPRC PTPRF CR2 SLC27A2 HLA-DPB1 PPP3CA CD99 PPP3CC SLC27A1 CD58 HLA-E MADCAM1 CHP1 CPT2 INPP5D VAV1 PCK2 ACSL1 PLTP GRB2 EHHADH ITGAV IKBKG NCAM1 BTK GLG1 ITGA6 CHUK SIGLEC1 CD81 CD2 ITGA4 BLNK NFATC1 PTPN6 HLA-DQB1 ITGAM ITGB1 NFKB1 RELA MAP2K1 SLC27A4 NFKBIB PMC4841712__F1 Regain control of p53: targeting leukemia stem cells by isoform-specific HDAC inhibition PIM1 USP22 HDAC8 ATM SIRT1 PMC5435887__F1 Main genetic and signaling pathway alterations in UMs and CMs PLCB4 TRIO BAP1 ARF6 BRAF MARCKS KIT PTEN MTOR RHO RAC1 RASA2 NF1 NRAS PREX2 PMC11155398__F4 Biological functions of SUMOylation cascade in tumors SUMO1 SUMO3 TRIM28 RNF146 CBX4 WTAP METTL14 YTHDF2 IRF1 METTL3 SAE1 TRIM21 PMC2670969__F4 PBT-1 induced genes in different pathways according to the KEGG and BIOCARTA pathway databases CDC2 BAD CDK6 CDK7 CDK2 MTOR GHR CCNH CDK4 PMC7166496__F5 Regional signaling pathway analysis of the genes associated with heart diseases SDHA HADHB DLAT HEL-S-162eP ALDH9A1 DLD CS HEL-S-87p HEL-S-26 ACSS1 PMC6559935__F1 Leptin and leptin receptor activation pathway STAT3 SOCS3 PMC11155398__F2 Biological significance manipulated by SUMOylation in tumors SUMO1 SUMO3 TRIM28 RNF146 RNF168 SENP1 MORC2 PIAS1 CSNK2A1 FOXK2 IGF2BP2 PMC5866057__F1 MTOR signaling pathway with potential contributions from GABA and Glu receptors CAB39 GIP SNCA PTEN VEGFA CS RHEB ABAT TSC2 IGF1 BCL2 TBP PRODH AVP PMC3967868__F1 Drug resistance mediated by AEG-1/MTDH/LYRIC MTDH AGO2 FOXO1 DPYD MMP9 MYC ATG5 SND1 PMC5983605__F2 Diagram of WNT (Wingless-type) signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC2811646__F4 Molecular targets in NFKB pathway modulated by PEITC and SFN COX2 SFN TNF PMC2811646__F3 Molecular targets in Nrf2/phase II enzymes pathway modulated by PEITC and SFN UGT1A1 GSTM1 KEAP1 MAF SFN PMC8068835__F11 Summarized interconnection between PC synthesis, trans-sulfuration pathway, folate cycle, methionine cycle, polyamine pathway, and trypanothion synthesis PEMT PC HEL-S-61p PMC9251307__F1 Molecular Mechanism of Caffeine in Preventing Bronchopulmonary Dysplasia in Premature Infants KEAP1 ATF4 HEL-S-44 PMC4817351__F8 Molecular pathways of proliferation, survival and senescence CDKN2A ROS1 CDK6 ALK NTRK1 CDK2 PTEN MDM2 MTOR RET CDK4 PMC8788178__F2 Multiple roles of mothers against decapentaplegic homolog 4 in tumorigenesis, stem cells, drug resistance, and cancer therapy SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC11835119__F4 Phyllanthus emblica–active components–target–pathway network STAT3 PIK3CA ALPL ADORA2A RAF1 ABCC1 GSK3B CHRM3 FAAH ERN1 MAOA MAPK3 CA3 ADRA2A CHRNB2 FGFR1 CSNK2A1 HEL-S-11 HEL-S-26 CA14 ABCB1 MAPK1 SCN1A HTR1D KCNK9 NTRK2 GRIK1 MIF CA5B TNF CA5A SCN5A GABRA6 GABRA3 SCN9A GABRA2 CHRM2 ADK OPRD1 MAPK10 BRD2 CA7 PDE2A CHRNB3 DUSP3 GABBR1 CHRNA3 KCNJ3 CA12 CHRNA6 SLC6A3 5HT1A APP SLC1A1 ACHE HEL-S-72p CHRNA7 OPRM1 NR3C2 HEL-S-162eP PBR KDM5C CA9 DDX3X HRH3 DYRK1A GABRG2 GRM4 ADRA2B GCK GRIN1 GBA2 TRPV1 HEL-S-28 VEGFA UGT2B7 GRM2 CDK5 HEL-75 HEL-S-22 CHRM1 GABRB2 BRAF MTOR RORA CASR SHBG CYP2C19 ABCG2 CYP1A2 TNK2 KCNJ6 GABRB3 MMP9 PTGS2 CACNA2D1 CASP3 MAP2K1 PMC3443126__F7 H2O2-modulated permeability increase and cytoskeleton reorganization via MARCKS phosphorylation in endothelial cells PLCG1 MARCKS RAC1 PMC6540205__F3 Activation of the prolactin signalling pathway in the mink uterus in activated versus diapause states TH PRL GCK PMC8126061__SF1 Iridin Induces G2/M Phase Cell Cycle Arrest and Extrinsic Apoptotic Cell Death through PI3K/AKT Signaling Pathway in AGS Gastric Cancer Cells CDC2 FAS CCNB1 PMC11835119__F7 Exploring the mechanism of action of Phyllanthus emblica in the treatment of epilepsy based on network pharmacology and molecular docking PMCH TRH OXTR LHB SCTR TSHR HEL-S-62p TACR2 CRH PRH GIP GHRL GHRHR PRLHR FSHR LTB4R LPA VGF UTS2 SPX GHR GRPR MLN LEPR TACR3 TRHR NR3C1 CALCR MLNR QRFP KISS1 APELA GHSR UTS2R PTH PTGIR GIPR AVP PMC6540205__F1 Activation of the PI3K/AKT signalling pathway in mink uteri in activated versus diapause states SYK BAD EBP PTEN CD19 MTOR ME1 MYC RAC1 EIF4E RHEB TSC2 BOLL BRCA1 BCR MEI1 PMC8600110__F1 Receptor-Mediated NETosis on Neutrophils TMPRSS2 SYK HMGB1 TLR9 MPO TRPM2 CXCR1 NLRP3 TLR4 NOD2 TLR8 TLR7 ACE2 PMC5445935__F2 Correlates of metastatic melanoma response to checkpoint inhibition B2M CTLA4 PMC8711145__F6 Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis NLRP3 TLR4 RIPK1 IL1B FADD MYD88 PMC3372530__F2 Diagram of genes that have been implicated in susceptibility to CL and ML disease caused by L TGFBR2 STAT3 FLI1 COL1A2 SP1 SMAD2 SMAD4 IL6 IL6R TGFBR1 PMC8711145__F2 Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis CASR GSDMD GPRC6A MAVS NLRP3 TXNIP NOD2 CMPK2 TNF PMC6574129__F5 Aurora kinase plus BTK blockade inhibits the chronic active BCR pathway and induces apoptosis in DH/DE-DLBCL SYK PLCG2 HEL-S-162eP PMC3291789__F1 Targeting the p53 signaling pathway in cancer therapy - The promises, challenges, and perils BAX FAS MSH2 TP53INP1 PERP LIF TIGAR GPX1 FANCC XPC DDB2 MDM4 SCO2 SESN1 MDM2 GADD45A SESN2 PMC9409103__F3 Recent Developments in the Understanding of Immunity, Pathogenesis and Management of COVID-19 TBK1 CGAS IRF3 PMC5140782__F1 Metabolic rewiring in melanoma GOT2 GLS HEL-S-133P GPT2 DHFR MPC1 MPC2 MYC PCK1 PDP2 GLUD1 PHGDH SHMT1 ASNS HEL-S-26 PYCR2 PMC11948033__F3 Modulation effect of TEVs on CD8+ T cell BMI1 OGT FAS HLA-G PMC5140782__F2 Metabolic rewiring in melanoma HMGCL NF1 BRAF PMC11948033__F4 Treatment strategies to reversing immune escape EPCAM PMC7013084__F1 CSCs alter the composition and functional properties of immune cell subsets, which results in an impaired CSC recognition and elimination by the immune system SIRPA CCL5 FOXP3 CCL2 CD47 PMC9686704__F1 Research Progress on Mitochondrial Dysfunction in Diabetic Retinopathy HEL-S-162eP ARHA PMC3501207__F1 Cholesterol Accumulation Regulates the Expression of Macrophage Proteins Implicated In Proteolysis and Complement Activation HSP90AB1 HEL-S-62p APOE CFH CD14 C1QB MIF ARHA SPP1 ITGAM IGF1 C1QA CFP IL1RN F2 GRB2 HLA-C YWHAZ PMC9258520__F1 Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications NRK SIRT7 NAPRT NMNAT1 KYNU SIRT4 KMO SLC22A3 SIRT5 NMNAT2 NAMPT SIRT2 SLC7A5 SLC12A8 SLC5A8 SIRT3 NNMT SARM1 SLC36A4 SLC25A51 NADK SIRT1 SIRT6 NMNAT3 PMC4964437__F2 Lipid mediators and HIF1A signaling in hypoxic prostate cancer (PCa) cells COX2 SPHK1 GSK3B SRC PMC4494663__F14 New Biology of Estrogen-induced Apoptosis Applied to Treat and Prevent Breast Cancer BCL2 TNF FADD PMC4604214__F3 Key Figure: Developmental and Disease-associated Pathways Regulated by Chromodomain Helicase DNA Binding Protein 7 (CHD7).CHD7 can affect the activity of several signalling pathways that control development GBX2 SMAD1 SEMA3A TBX1 MLL2 OTX2 SOX2 FGF10 FGF8 GLI3 PMC11742855__F4 Сomplex interplay between cell cycle-related genes and their influence on various signaling pathways in NETs EPCAM RICTOR EGFR BCL2 EZH2 MTOR RET CDK4 HEL-117 PMC11280205__F5 Mechanism in the development of a higher 2D:4D ratio SMAD2 SPHK1 NOTCH3 PMC5855762__F1 The molecular signaling pathways underlying the effects of CC2238/AANP in endothelial cells, smooth muscle cells, and platelets GAL ATP8 GIP PTEN PMC7693470__F1 Schematic simplified representation of thyroid hormone synthesis GPX2 TG PMC8564336__F1 Biological and clinical implications of metastasis‐associated circular RNAs in oesophageal squamous cell carcinoma CDH2 GSK3B PTEN WNT3 CTNNB1 PMC11506032__F5 Pathophysiology, Treatment, and Prognosis of Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome: A Review STAT3 STAT1 CXCL13 STAT2 MTOR VEGFA PMC8016949__F1 Assessing fatty acid-induced lipotoxicity and its therapeutic potential in glioblastoma using stimulated Raman microscopy FAS DGAT1 DGAT2 PMC5214845__F3 Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors MAL IRF3 TRAF6 MYD88 PMC3428377__F3 Signaling pathways for estrogen production and action JUN JUND PI3 PMC4522054__F1 Conceptual model of general health factors, salient CHD pathogenetic pathways and CHD hallmarks CRP TF IGF1 VCAM1 MIF MPO PMC8015649__F3 Mitochondrial Pyruvate Carriers are Required for Myocardial Stress Adaptation OGA OGT PHGDH PC PMC3706484__F5 Xenogeneic-Free Protocol for Isolation and Expansion of Human Adipose Stem Cells for Clinical Uses IL1R2 EZR HBEGF HLA-F FCRLA EPOR HLA-DRB1 F13A1 B2M IL10RA PMC11980100__F9 Histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks RAD50 MRE11A H2AX ATM PMC2913378__F3 Signaling pathways that mediate actomyosin-dependent disruption of the epithelial barrier in inflammation IFNG RHO TNF IL1B PMC8038106__F1 Molecular pathophysiology of hereditary hemorrhagic telangiectasia (HHT) BMPR2 SMAD2 PAH PMC8469305__F5 Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NFKB Signaling Pathway TG FASN IL1B PMC8375232__F4 Functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma EIF3A YTHDF2 AAG1 PMC12084965__F7 Green tea epigallocatechin gallate attenuate metabolic dysfunction-associated steatotic liver disease by regulation of pyroptosis GAL GSDMD NLRP3 TNF PMC8375232__F5 Functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma WNT2B CTNNB1 PMC8004548__F1 Interleukin-6 classical and trans-signaling SOCS1 ADAM17 SOCS2 ADAM10 PMC6220136__F1 EGFR signaling and generation of Treg and tol-DC STAT3 EGF EGFR AREG FOXP3 PMC7230049__F1 Rationale for homocysteine removal by the administration of a full array of activated micronutrients VIT DHFR CHDH MTRR HEL-S-61p MTR PMC3816537__F3 Pathway based analysis of high ranking composite score genes reveals key signaling pathways associated with PDAC clinical progression FAS CBL EGFR DFFA CASP3 PTEN MTOR DFFB SRC KRAS FADD PMC4080280__F4 Stage-specific expression of individual genes in Ras and Wnt pathway orchestrate cardiogenesis STAT3 EGF SMAD1 BMPR1A PIK3CD GSK3B PTEN IKBKG MAPK6 CTNNB1 MAPK4 SOST MAP2K6 PI3 MAPK12 MDM2 MAP2K3 TEF BMPR2 JUN LIF APC SOX2 LRP6 PTPN11 FOS ACTR2 MAPK7 FGL2 MAP2K5 GRB2 ERAS PMC8038106__F2 Targets of bevacizumab and tacrolimus HEL164 BMPR2 SMAD1 DKFZp781O1323 PMC8456159__F7 Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus STAT3 BAX DPF3 CEMIP IL23R PMC3225503__F6 Pathway model based on vision related TMT-associated gene expression changes indicating a possible mechanism for TMT elicited neurobehavioral changes ARR3 CRX RHO PMC6451295__F3 Different sources of EVs in the cancer-to-stroma communication network FGF8A EGFR SIRPA CD63 PMC5140782__F3 Metabolic rewiring in melanoma GPX4 ARHA GPX1 HEL-75 HEL-S-44 PMC8529160__F4 Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury ADAM17 MAK ADAM10 PMC4973254__F5 Predictive Immunohistochemical Markers Related to Drug Selection for Patients Treated with Sunitinib or Sorafenib for Metastatic Renal Cell Cancer PTEN RET VHL PMC4882277__F7 Proposed mechanism by which miR-21 links hepatic lipid accumulation and the development of cancer CCNB1 CCND1 PMC3410018__F5 Immune cell types implied to be involved in celiac disease by pathway analyses STAT3 ICOSLG CD80 FAS TNFSF6 APC CCR3 PTPRK CTLA4 IFNG ICOS SH2B3 IL18RAP IL1B PMC7339077__F2 Biomarkers of primary and acquired resistance occurring in the (A) tumor microenvironment (TME), (B) in the tumor, and (C) host factors TIGIT PTEN B2M LAG3 CTNNB1 PMC4899229__F1 Type III IFN signaling pathway STAT3 STAT1 STAT2 TLR9 IRF3 TLR7 PMC8117215__F2 Early Emergence of Adaptive Mechanisms Sustaining Ig Production: Application to Antibody Therapy ELF2 MBTPS2 ATF4 XBP1 PMC5935119__F2 Genetics of coronary artery disease: discovery, biology and clinical translation LPL ANGPTL4 ANGPTL3 PMC5334259__F2 Cellular unfolded protein response mechanisms XBP1 PMC7149109__F1 Antiviral innate immune response TBK1 MAVS STAT2 IFIT3 IRF3 TRAF3 TRAF6 MYD88 HEL-S-92n STAT1 IFNAR2-IL10RB JAK1 TYK2 IL10RB PMC7736127__F1 Neuronal insulin signaling and brain structure in non-demented older adults: The ARIC Study IGF1 GSK3B IRS1 PMC5074855__F7 Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogen Candida albicans NRG1 TPK1 PMC7682536__F1 Spectrum of RAS-MAPK pathway disease genes and associated RASopathies HRAS CBL RAF1 SPRED1 SHOC2 RIT1 BRAF RRAS CS GRB2 KRAS PMC3492703__F1 Biosynthesis and posttranscriptional processing of miRNA DGCR8 DICER1 DROSHA PMC3943767__F3 Proteolytic pathway that controls glucose uptake in fat and muscle UBL3 TBC1D4 IRS1 PMC3775123__F2 Signaling modules that are important therapeutic targets to counteract muscle wasting IGF1 SGK1 JUNB SMAD2 IGF1R MTOR PMC3632064__F3 Motor axons release Agrin and ACh MUSK CRK LRP4 CRKL PMC3775123__F1 Signaling modules responsible for autophagy-lysosome pathway in the adult ATG10 GABARAP ATG3 PINK1 ATG12 TFEB BNIP3 MUL1 KIAA1632 BNIP3L ATG5 PMC7232389__F6 Eukaryotic initiation factor 2 (EIF2) signaling pathway RPL8 AGO2 PIK3R2 RPL38 SPI1 RPS8 RP1 PIK3C2B RALA RPL28 RPL41 RPS21 RPS23 AGO1 EIF3K RPL12 RPL7A RPL13 RPS7 RPL3 RPS26 RPS24 PTBP1 FAU EIF3D RAP1A EIF3M RPL9 GRB2 AKT3 NOX4 RPL39 EIF3S3 RALB RPS13 RPS3 RPL27 ATM RPL14 EIF4A2 RPL7 RPS6 RPS5 RPS2 RPL21 RPL6 EIF3C RPL4 RPS12 RPS9 RASD2 PMC7232389__F7 Sirtuin signaling pathway ACLY PPARG PPIF HEL-S-133P ATG14 MTOR SIRT2 SDHD ACSS2 SDHA SDHB NR1C1 HSF1 APP PAM16 RRP9 PFKM SDHC PMC8259493__F2 Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies PKD1 MTOR PMC6627458__F8 Mechanisms underlying the anti-inflammatory effects of oxytocin (OT) on lipopolysaccharide (LPS)-stimulated microglia TLR4 ATF4 IL1B PMC5687887__F1 Summary of pathways and signals discussed in this review that induce NK cell activation and/or NKG2D ligand expression in tumor cells and in virus-infected cells HDAC3 ATR CGAS ATM IRF3 ATF4 PMC8005482__F1 Inactivation of tumor suppressors in GBM cells that affect GAM biology STAT3 CCR5 CCR2 PTEN MTOR CCL5 TNF CCL2 YAP1 CTNNB1 LOX NF1 CX3CR1 CX3CL1 SRC PMC9678997__S1 Tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis TH PINK1 LRRK2 PMC4747365__F7 Molecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells BAX CASP9 CASP3 PMC3743775__F6 Cis Association of Galectin-9 with Tim-3 Differentially Regulates IL-12/IL-23 Expressions in Monocytes via TLR Signaling STAT3 STAT1 IRF3 PMC9237930__F1 New dawn for cancer cell death: Emerging role of lipid metabolism ACAT1 LPCAT2 HMGCR CD36 EGFR ROCK1 FASN LDLR ALOX12 SQSTM1 ABCA1 CPT1A PMC9237930__F2 New dawn for cancer cell death: Emerging role of lipid metabolism CD36 FASN WDR76 SREBF2 FADS2 ADFP ME1 SIRT1 INSIG1 SIRT6 PMC7335402__F3 Relevant biological network containing the DPTs and their associated genes () was constructed using Cytoscape version 3.8.0 ATG101 ATG10 ATG12 ATG5 PMC5516940__F3A Proteomics analyses of prostate cancer cells reveals cellular pathways associated with androgen resistance SYK BAD EBP RBL2 PTEN CD19 MTOR MYC RAC1 TSC2 BCR PI3 RXRA MDM2 CCND1 PMC5043055__F5 Pathways leading to lignin and heteroxylan in maize pericarp at stage R3 CAD JCAD PMC9170863__F4 TEMTing target? Clinical and experimental evidence for epithelial-mesenchymal transition in the progression of cutaneous squamous cell carcinoma (a scoping systematic review) KLF4 STAT3 GAL AXL DKK1 EGFR SOX2 TRAM1 MTOR DDC PRAF2 CTNNB1 PMC6881378__F11 Proposed mechanisms for the role of MC mediators in response to tumor cells GAL PCNA CP PMC6368395__F3 Immunosuppressive agent-induced cell-intrinsic tumorigenic pathways CXCR3 STAT3 ATF3 HGF PMC6858953__F1 Claudins inhibit multiple oncogenic pathways LATS1 PTEN IGF1R PDK2 CCND1 PMC6368395__F4 Oncogenic viral infections in post-transplantation malignancies FAS EGFR FADD PMC8413833__F8 Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas BAX TIMP3 CDK2 MIF PMC3887921__F2 Regulation of autophagy by nutrient signals ATG101 RHEB TSC2 TSC1 ULK1 UVRAG AMBRA1 MTOR PMC4905265__F1 Schematic description of multiciliogenesis MCC ARHA FLNA PMC9364625__F5 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity HEL-S-133P CD36 FASN TLR8 AHR FOXP3 MTOR PMC9364625__F3 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity CCR7 CCR4 GCK CCR8 PMC9364625__F4 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity TFAM PTEN FOXP3 PMC4314111__F2 Rise of regulatory RNA CTCF AGO1 EZH2 DROSHA PMC7143458__F3 Location of differentially expressed genes (indicated by red boxes) in the purine metabolic pathway OMP PMC6889944__F7 Proposed antifibrotic mechanism of G SMAD2 SMAD4 PMC10530916__F8 Endoplasmic Reticulum Stress-Related Ten-Biomarker Risk Classifier for Survival Evaluation in Epithelial Ovarian Cancer and TRPM2: A Potential Therapeutic Target of Ovarian Cancer STAT3 PPARG STAT1 SP1 NFKB1 RELA HIF1A IL6 PMC8687677__F1 The Role of Gut Microbiota in Diabetic Retinopathy NLRP3 TLR4 HP MYD88 PMC9364625__F2 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity CD36 MTOR PMC6341905__F1 TGF and RBM5 signaling cascade BAX EGF BAD TGFA PTEN RBM5 PMC8199164__F4 Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer ATR RAD50 RAD51 TIMELESS H2AX NRP1 PLK4 MDC1 REV1 MRE11A BRCA1 RNF168 RNF8 PMC4449425__F2 Activation of canonical (Wnt–Beta-catenin) pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC6934488__F6 Metabolic network diagram between phenylpropanoid biosynthesis pathway, pentose phosphate pathway and proline metabolic pathway CAD PRODH PMC9043410__F4 Structure-based identification and pathway elucidation of flavonoids in Camptotheca acuminate TH CAST PMC7567033__F1 Scheme of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in the regulation of autophagy process EIF4EBP1 EGFR ULK1 UVRAG ATG14 PTEN DEPTOR ATG101 RHEB TSC2 TSC1 NF1 AMBRA1 PMC11414392__F11 RUNX1-MUC13 regulatory mechanisms in CRC metastasis MUC13 RUNX1 CCND1 AXIN2 PMC9226665__F6 Endotoxins Induced ECM-Receptor Interaction Pathway Signal Effect on the Function of MUC2 in Caco2/HT29 Co-Culture Cells CD44 TNC AGRN HSPG2 ROCK2 MYL2 LAMB2 IBSP ARHA SRC ITGAV PMC8615041__F1 IL-36A and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling STAT3 JUN TIRAP CD14 IRAK1 IL36A IRAK2 MTOR IRAK4 FOS MYD88 ATG3 ATG12 TLR4 ATG5 PMC7272533__F1 IL-18 signaling pathway ATR BAD FAS CYCS PTMS PTEN POR tmp_locus_29 IL18 PRKCA CHUK HEL-S-11 NACA BAX JUN TRIL ACADS FOS DEK ATF3 RELA REL FADD ACR LCK PMC8070103__F1 RAF-MEK-ERK pathway is activated by H/K and NRAS upon extracellular stimuli ARAF RAF1 BRAF NRAS PMC2711664__F1 Signal transduction mechanisms implicated in leptin action STAT3 MTOR PMC8070103__F4 RAF1 negatively regulates the proapoptotic Hippo pathway by binding to MST2 upon growth factor stimulation LATS1 FAS RAF1 NRAS PMC10982327__F2 Molecular pathways involved in animal glaucoma models at the level of retinal ganglion cell FAS SMAD2 SMAD4 SRC PMC8163539__F4 Systematic Pharmacology Reveals the Antioxidative Stress and Anti-Inflammatory Mechanisms of Resveratrol Intervention in Myocardial Ischemia-Reperfusion Injury CD40 tal-1 TIRAP PDC MIP RAC1 MYD88 PMC2869556__F1 Metabolic folate pathway DHFR MTRR MTR PMC2898136__F6 Eicosanoids and cancer CDC42 LTB COX2 EGFR CCL2 CXCR4 FGF2 PMC2898136__F3 Eicosanoids and cancer EGFR GSK3B CCR7 MMP2 SRC PMC2898136__F1 Eicosanoids and cancer LTB LTA COX2 PMC5940378__F7 Proposed aPPD anti-prostate cancer mechanism BAX MDM2 PMC4649380__F5 CTGF Signaling Network ModelWe compiled a list of molecules known to be associated with hematopoiesis () and reported to interact directly or indirectly with CTGF and each other using EXERBT text mining and Pathway Commons, respectively ( and ) FZD5 TGFB1 FZD10 EGFR SMAD2 GSK3B SMAD4 PTEN MYC SKP2 ITGAV CTNNB1 TGFBR2 IGF2R FZD8 CDK6 FZD3 CCNE1 FZD1 CCND1 CDK4 FZD2 LRP5 FZD7 ITGB3 FOS CCNE2 FZD4 CDKN1A FOXO1 CDKN1B CDK2 EP300 PMC7962393__F7 Functional Prediction of the Key Genes Involved in HBV Associated HCC DEPDC1 AURKA TGFB1 TRADD PCNA HMMR STAG1 SMC3 NEK2 SMAD2 KIF20A SFN SMAD4 ZWINT CENPE CCNA2 MYC SKP2 CCNH KIF23 RB1 CDK6 PRC1 ATM CCNB1 TBP TOP2A SMC4 GINS1 CDC2 DBF4 CENPF KIF11 KNTC2 ORC2 HDAC1 MKI67 RAD21 NUSAP1 CDCA3 PRKDC MCM3 SKP1 CDK2 MCM2 PMC4928090__F4 Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish MAPK1 STAT3 PPP1R3A FOXO3B IL10 SGK1 GYS2 PYGB TNFSF6 IL7R PRKAA1 CRK CBL CDKN1A CCNG2 PPARGC1A CCND1 PMC2518078__F1 Cotargeting survival signaling pathways in cancer RHEB TSC2 BAD TSC1 PTEN GRB2 EIF4E PMC7439842__F1 Known and speculated roles of NADPH oxidase (Nox) and ROS in G-protein-coupled receptor (GPCR) transactivation of epidermal growth factor receptor (EGFR) EGF EGFR SRC PMC7312018__F4 Tamoxifen modulation of membrane and nuclear estrogen receptor (ER) signaling TF EGF TGFB1 EGFR GPER HEL-S-28 SRC PMC6319021__F5 Proposed mechanism for kCer acting as a Sema3A-like ligand SEMA3A FYN LIMK1 NRP1 RAC1 PMC20092__F5 A model for the v-Crk-mediated signaling pathway CRK JUN GRB2 PMC5852877__F1 TLR4 intracellular signaling pathways TBK1 TIRAP TAB3 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC12023698__F7 Working model of AMPK-ULK1 activating autophagy in nZnO induced bone regeneration ULK1 SP7 MSC RUNX2 PMC9520460__F10 Complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment HEL-S-62p HP CD163 PMC10891054__F9 PART1/AC007728 FCGBP PMC7757025__F3 Signal transduction of BII spectrin in tumor STAT3 IGF2BP3 SMAD2 APC GSK3B LRP5 SMAD4 LRP6 IL6 YAP1 CTNNB1 EPCAM FANCD2 TLR4 HES1 CDK4 PMC9224204__F4 Chronic LY341495 on Hippocampal mTORC1 Signaling in Mice with Chronic Unpredictable Stress-Induced Depression EIF4B BDNF EIF4E PMC8598308__F5 Genome-Wide Correlation of DNA Methylation and Gene Expression in Postmortem Brain Tissues of Opioid Use Disorder Patients NAPEPLD RIMS1 DAGLA ABHD6 CNR1 MGLL FAAH PMC5116860__F3 Mechanism of action of metformin HEL164 PKD1 PTEN MTOR EIF4E PMC6513775__F4 Possible site of action of beta (B) asarone in apoptosis, cell proliferation and growth BAX CDK2 PMC8450533__F4 RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in Dexamethasone-Treated Human Trabecular Meshwork Cells CDC42 IDE BAD CAD VAV2 LAT RHO DAO CRK RAD1 NF1 MB BIK PMC8450533__F5 RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in Dexamethasone-Treated Human Trabecular Meshwork Cells BAD VASP THSD4 SMAD2 SMAD6 SMAD4 HEL-S-28 RGMB NODAL ARHA TNF SHE HFE2 BAMBI IFNG SMURF1 E2F4 SKP1 SMURF2 PMC4889429__F2 MiR-155 on virulent (green) and avirulent (yellow) Mycobacterium species infection in macrophage PKIA TNF PMC8326283__F8 Liquid–liquid phase separation in human health and diseases SPOP PMC12230579__F7 Network of compound-reaction-enzyme-gene PNLIPRP2 GLS LYPLA2 ALDH16A1 CS LIPA LIPC HMOX1 NAGS ALDH1A3 ALDH3A1 OPLAH GPT CHKB UGT1A1 UGT1A3 CRAT PLD2 GCLM GPT2 FLJ10842 LIPG ALDH3A2 SDHA UGT2B15 OGDH PEMT LIPE DLD ChAT CHKA HEL-75 PMC8326283__F6 Liquid–liquid phase separation in human health and diseases ZAP70 CGAS SOS1 LAT GRB2 LCK PMC7696687__F3 Various physiological roles of intracellular visfatin (iNAMPT) SIRT3 NRK SIRT7 NMNAT1 NADK NMNAT2 SIRT2 SIRT1 NMNAT3 SIRT6 PMC5518130__F4 Differently expressed protein-coding genes and lncRNAs participating in the AMPK signaling pathway via DAVID KEGG analysis RHEB EEF2K TSC2 FAS IGF1 INSR POC1A CD36 F2 CFTR MTOR INS PMC3875959__F3 Proposed model for the role of lncRNAs in RB pathway CDK6 CCND1 PMC4470747__F1 Innate Immune Evasion In Re-Emerging RNA Viruses TBK1 MAVS AGO2 TRIM25 TLR3 IRF3 IRF7 TRAF6 PMC7269781__F3 BRCA pathway ATR BACH1 ATM ATF1 PMC10384352__F2 Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections C1S C1R C4B_2 PMC10384352__F3 Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections SYK TANK IRF3 ATG5 LILRB1 PMC5989766__F8 Impaired Akt signalling leads to iron accumulation APP PCBP1 HEL-S-44 PMC4191269__F1 Controller composed of the KDEL receptor (KDELR) and the Gq and Gs signaling pathways maintains the homeostasis of membrane transport at the Golgi complex ATF3 SP1 ATF1 ATF2 SRC CREB1 PMC7052944__F5 Regulatory effect of GPC3 on the WNT signaling pathway GSK3B ARHA GPC3 CTNNB1 PMC5021733__F1 Negative regulators of Toll-like receptor signaling SOCS1 TLR1 LTA TLR3 TLR4 MAL TLR9 TLR5 IRF3 TRAF3 TRAF6 MYD88 PMC5823541__F1 MTOR signaling pathway and the cell cycle pathway associated with lung adenocarcinoma as reported in TSC2 STK11 TSC1 NF1 ATM MDM2 MTOR PMC9218900__F3 Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation STAT3 HMGB1 GSDMD NLRP3 IRAK1 TRAF6 REL IRAK4 NFKBIZ PMC4370254__F1 Schematic depiction of sonic hedgehog (SHH) synthesis, secretion, and signaling HHIP BOC SUFU PTCH1 DISP1 SHH SMO GAS1 GLI3 PMC7696687__F1 Three-mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis pathways NMNAT1 NMNAT2 NMNAT3 PMC5354895__F14 Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGFB signaling CDH2 SP1 PMC8399569__F5 Plant Salicylic Acid Signalling Pathway Regulates the Infection of a Biotrophic Pathogen in Grasses Associated with an Epichloë Endophyte COIL MYC PMC11192764__F1 TGFB complex and TGFBR signaling pathways SMAD2 TGFBR1 PMC7696687__F2 Salvage (rescue) pathway remains a predominant pathway to meet NAD+ cellular requirements NAMPT PMC7727191__F3 Signaling pathways which CD44 regulates CD44 MMP2 MDM2 MMP9 SRC CTNNB1 PMC5844972__F2 Three pathways of the unfolded protein response (UPR) GLS ATF4 XBP1 PMC6148250__F8 S100A10 and PAI-1 are regulated by Smad4-dependent TGFB1-mediated signaling and FOXC2-mediated PI3K signaling TGFB1 FOXC2 S100A10 SMAD2 SMAD4 MTOR TGFBR1 PMC3723114__F1 Canonical and noncanonical TGFB signaling systems activated during mammary tumorigenesis LOX SMAD2 SMAD4 ARHA GRB2 PMC7349823__F7 Distinct mechanism of miR-210 in the regulation of mouse and cattle adipogenesis ZNF423 TCF4 CTNNB1 PMC6558396__F1 Drosophila Hippo pathway Network WBP2 PATJ ZYX SCRIB PALS1 PMC8590693__F7 Hypothetical model illustrating multiple actions of NCT-58 on cancer stem-like properties, HER2 signaling, and trastuzumab resistance in HER2-positive breast cancer CD44 HSF1 PMC8431385__F2 Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts BAD LTA FAS TNFRSF10B MCL1 CYCS BBC3 IGF1R TNFRSF25 MYC IKBKG TNFRSF18 CDKN2A BIRC5 BCL2L1 BCL2L2 MAP2K4 CASP4 NFKBIE BOK CHUK MDM2 HRK APAF1 BAX CASP9 CASP2 TNFSF6 IRF3 IRF4 BCL2L11 DFFB IGF2 IRF6 PRF1 IKBKB IRF2 BCL2 MAPK10 TNFSF10 BAK1 REL CASP10 NFKBIB DIABLO PMC8431385__F3 Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts TF POLD3 RFC4 RFC1 NOX5 RFC2 PMS2 PCNA GSTT2 MGST1 GPX3 GPX1 NOX4 MAOA MAPK14 HMOX1 NOX3 TXN2 POLD4 POLD2 POLE HEL-S-44 UGT1A3 MSH6 MSH2 POLE2 MSH3 JUNB CYP1A1 RPA1 FOS POLE4 NFKB1 POLE3 GCLC NFE2L2 XDH MAPK10 RFC3 CYBB HEL-75 PMC4542789__F3 Sub-network of genes regulated by E2F3, E2F4, and the E2F functional group TP73 MYB PCNA CYC1 TYMS CCNA2 SKP2 NOX4 CASP6 CCND2 TTK CCNB1 FBXO5 ATAD2 DBF4 ZNF703 RAD51 MSH2 ECT2 ORC2 MAD2L1 RBL1 PTTG1 CCNE2 MCM7 PEG10 TK1 MCM10 ECE1 MCM3 MCM5 MCM6 GAB2 PMC3429121__F2 Metabolic flux through the purine salvage pathway in L APRT ASL GMPR GDA PMC6592070__F1 CAMP/PKA pathway in S RGS2 GAL PGM2 PMC6592070__F2 CAMP/PKA pathway in C GAL PGM2 GIP PMC10572524__F7 DEGs in NOD/Toll-like receptor signaling pathway NAIP STAT2 TLR4 IRF9 TLR5 IRF3 CXCL2 CARD9 PMC11820663__F4 Macrophage polarization-related signaling pathway (by Figdraw) STAT3 STAT1 TLR4 SMAD2 IRF3 MYD88 PMC11592674__F6 Simulated microgravity effects on transcriptomic profile of bone marrow cell culture FAT4 ALPL PATJ PALS1 WTIP RUNX2 DCHS1 YAP1 LATS1 FRMD6 LATS2 LIMD1 TEAD2 YWHAQ AMOT CASP3 MEIS1 AJUBA NF2 SRC LPP CTGF PMC7709628__F1 Interplay between nutrient-sensing pathways potentially affecting health span IGF1 FGF21 MTOR INS PMC7709628__F2 Specific nutrients and dietary manipulations affecting insulin/insulin-like growth factor signaling (IIS) pathway IGF1 INSR FGF21 MTOR INS PMC11770381__F5 Neutrophils in CAC STAT3 ROS1 GPX4 CXCL1 CD177 MMP9 PMC6173473__F3 Crosstalk of bone cells within bone marrow regulates bone remodeling, adipogenesis, hematopoiesis, and angiogenesis PPARG LEP LEPR ADRB2 MSC EPO CXCL2 HIF1A PMC6592070__F3 Connections between the cAMP/PKA pathway and virulence-related functions in C NRG1 ROS1 CIRSR PMC5250648__F2 Ca2+ induces autophagy LRRK2 MCOLN3 TFEB MTOR PMC2861491__F1 Destruction of the Beta-catenin (Beta-Cat) destructor Axin TNKS2 APC CTNNB1 PMC5357773__F5 FcGRIIIb initiates signaling pathways to the nucleus SYK SRC PMC8805398__F1 Rapamycin, Acarbose and 17Alpha-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation IL6 TNF EIF4E PMC6813288__F3 Mechanism of NFKB activation by PA TLR4 GSK3B EIF2A TRAF6 PMC6548160__F3 CSC signaling pathways which are regulated by BRCA proteins BRCA1 DHH SHH IHH JAK1 NOTCH1 PMC2575845__F1 RLR signaling pathway and its negative regulatory molecules TBK1 NLRX1 RNF125 TRIM25 IRF3 TRAF3 ISG15 TRAF6 CYLD FADD PMC2782488__F1 Cytokine signaling modules in inflammatory responses SOCS1 STAT3 RORC IL21R IL7R SOCS3 FOXP3 IL23R RORA PMC2782488__F3 Cytokine signaling modules in inflammatory responses STAT3 CXCL1 SOCS3 CCL2 PMC6122031__F9 Putative regulatory mechanisms of the FNM process MYB APC PMC2864712__F10 PAK4 regulates adhesion and migration via multiple signalling pathways HGF PAK4 ARHA PMC8931538__F9 JAM-A–tetraspanin–AvB5 integrin complex regulates contact inhibition of locomotion CD81 CD9 CSK SRC RAC1 SRA1 PMC8429033__F7 Blocking the Hepatic Branch of the Vagus Aggravates Hepatic Ischemia-Reperfusion Injury via Inhibiting the Expression of IL-22 in the Liver STAT3 CCND1 TYK2 PMC3868890__F2 Main synaptic signaling mechanisms of endocannabinoid and hypocretinergic systems HCRTR2 INA HCRTR1 HEL-S-11 PMC1322299__F1 Tweaking Microtubules to Treat Scleroderma SMAD2 SMAD4 PMC5492089__F7 Schematic of canonical Hh pathway TH SMO GLI3 PMC4110715__F5 GeneGo graphic representation illustrates Transcription Androgen Receptor (AR) nuclear signaling MAPK1 HRAS STAT3 EGF IGF1 EGFR GRIP1 MMP2 GRB2 NCOA1 PMC3872778__F2 Similarities between NAA synthesis and citrate synthesis MAL PDC CS PMC3590129__F7 Differential Expression of miR-145 in Children with Kawasaki Disease TGFBR2 SMAD2 SMAD4 ARHA KRAS TGFBR1 PMC5975367__F3 Targeting Autophagy in Cancer STAT3 EGF JUN EGFR ATM PTEN MDM2 MTOR PMC4222471__F2 RAS signaling pathway and genes mutated in juvenile myelomonocytic leukemia (in black) CBL RAF1 SOS1 NF1 GRB2 MTOR PMC4197205__F1 An IL-1-induced signaling pathway is mediated by K63-linked polyubiquitination of IRF1 SPHK1 CCL5 TRAF6 PMC7349538__F9 Biological model proposed for the yeast response to stress caused by inorganic acids MID1 GAS1 HEL-75 PMC2213034__F8 Our model for the mechanism of anti-CD63 inhibition SYK FYN LYN CD63 GAB2 PMC9331907__F3 Metabolism on Macrophage Polarization Under Different Disease Backgrounds FAS IL1B PMC7488362__F2 Diagram depicting the mechanism of CR involving multiple signaling pathways ROCK2 EGFR SMAD2 APC PTEN MTOR RHO CTNNB1 CD44 HBEGF ROCK1 SRC GAB2 NOTCH1 PMC5105878__F1 Schematic overview of the stepwise mechanisms involved in the development of immunoglobulin E (IgE)-mediated food allergy IL25 TSLP IL33 PMC8501036__F7 Proposed mechanistic pathway for the Fe2O3@KO2/zeolite catalyzed hydrogenation of CO2, highlighting the efficacy of our multifunctional system FER COCH IMPACT PMC10648679__F1 PSCs have emerged as a promising candidate for stem cells in PDAC IGF2 CTNNB1 PMC7760557__F9 Melatonin in mitochondria of WT mice during cardiac aging HMOX1 NLRP3 KEAP1 INA AMT MFN2 FADD PMC6570498__F1 Endogenous H2S production, metabolism during methionine cycle PMC5946314__F1 Manipulating the PD-1 pathway to improve immunity ZAP70 APC PMC8752351__F3 CD36 in cardiovascular disease INSR CD36 FOXO1 PMC2853371__F9 CD28 costimulation, IL-2 signaling, and mTOR pathway regulate Otub1 and GRAIL expression, controlling proliferation in primary naive CD4 T cells APC PC MTOR PMC9616467__F8 Embryonic transcriptome unravels mechanisms and pathways underlying embryonic development with respect to muscle growth, egg production, and plumage formation in native and broiler chickens MUSK EGFR SMAD2 IGFBP1 PRKAG2 NR1C2 MYOZ2 IGFBP2 ACACA MTOR CCNB3 HEL-S-42 TSC22D2 PDE3A NRAS PDE4D GCK CCND3 CAV3 CAV2 RHOF EIF4EBP1 FASN ROR2 LDHB ARHA IGF2 GDF5 ACACB ALDOB IGF1 FOXO1 HEL-S-162eP RHOB SOS2 MAP3K7 PRKAB2 ENO1 MAP2K2 GRB14 SMURF2 PMC6668486__F2 NK cell transduction pathways involved in primary immunodeficiencies IL15 IFNG STAT1 STAT2 IFIT1 RELA RELB JAK1 DOCK2 PMC3248020__F9 Schematic representation of S100A7-mediated signaling that inhibits proliferation and motility in ERA+ breast cancer S100A7 GSK3B CTNNB1 PMC7073073__F8 Representation of ATF6 acting on the TGFB–Smad pathway for induction of fibrosis genes COL1A1 SMURF1 TMEPAI SMAD2 SMAD4 SMURF2 TGFBR1 PMC8100607__F3 Reporters of Cancer Stem Cells as a Tool for Drug Discovery FOXJ1 HEL-S-53e SOX2 CTNNB1 PMC8100607__F1 Reporters of Cancer Stem Cells as a Tool for Drug Discovery SOX2 ABCG2 PMC9378776__F2 Tryptophan in Chlamydia trachomatis persistence CYP1A2 IL10 AHR ARG1 AHRR CYP1B1 CYP1A1 PMC9414242__F1 Recent Advances in Nanoparticles-Based Platforms Targeting the PD-1/PD-L1 Pathway for Cancer Treatment CD80 NPS APC PMC5015042__F1 The mTORC1 amino acid–sensing pathway RHEB ARF1 CASTOR1 SLC38A9 PMC7019991__F2 Representative image describing the role of the NOTCH/JAG1 pathway in AML-MSCs of a model describing MSCs in human BM niche KITLG HES1 CD34 PMC11874752__F8 Schematic diagram displays the function of FLJ in CRPC ULK1 ULK2 PMC11635105__F4 STRING protein-protein interaction networks for the differentially methylated circadian pathways-related genes in HS PELO CSTF3 AGA PMC6563219__F3 Pathway visualization using downregulated differentially-expressed unigenes in Axon guidance, Regulation of actin cytoskeleton and Adherens junction CDC42 ROBO2 DCC FYN NCK1 APC GSK3B SMAD4 ARHA ROBO1 SRC CTNNB1 PMC6563219__F4 Pathway visualization using downregulated differentially-expressed unigenes in cAMP signaling, Focal adhesion, Calcium signaling, Hippo signaling in fly and Notch signaling CRK SCRIB RHO GRB2 CTNNB1 GLI3 PMC4111923__F2 An example of a CN: the EGF signaling pathway includes > 60 proteins and has several alternative pathways (from http://www.sabiosciences.com/pathwaycentral.php, where many other networks are also shown) STAT3 EGF EGFR RHO RAC1 STAT1 RAB5A PAK1 CSK MUC1 ERBB2 GRB2 JAK1 PMC7723514__F6 Pimozide in prolactinoma bromocriptine resistance PRLR PRL CCND1 PMC4060531__F3 Genetic Basis of Diffuse Large B Cell Lymphoma CD40 CD79B CD79A BCL10 BCR CARD11 IRF4 BCL6 MYD88 PMC7311368__F1 Obesity and Breast Cancer: The Role of Crown-Like Structures in Breast Adipose Tissue in Tumor Progression, Prognosis, and Therapy IL33 CCL2 IL1B PMC6815593__F9 Schematic mechanism of matrine signaling pathway that inhibits cell growth and leads to cell death in HL-7702 cells CASP9 FAS CASP8 KEAP1 CASP3 CDK2 PMC5336494__F2 Diagram of signaling pathways that control Notch expression in PC PKD1 CYR61 EGFR ASPH PMC8076903__F1 TRP Channels in Brain Tumors STAT3 EGF TRPM7 FAS CERK HGF TRPC1 TRPV1 RHO MLSN2 RAC1 TRPM8 ATF3 GFAP TRPM2 TRPA1 IGF1 TRPV2 MCU GSC TRPC6 PMC4086465__F1 NKT-cell subsets: Promoters and protectors in inflammatory liver disease FAS APC PDC PMC5336494__F1 Diagram of Notch signaling MMP9 CCND1 PMC6142530__F1 Novel agents and pathways under investigation in MDS MTOR HEL-S-26 PMC2856528__F1 The three complement activation pathways, converging to cleave C3 C2 C1S C1R C4B_2 PMC2963059__F2 Non-canonical Wnt pathways CDC42 BCL9 NLK DAAM1 CTNNB1 PMC1998879__F2 Molecular pathway associated with neuronal migration DAB1 DCX VLDLR NDEL1 PMC2963059__F1 Canonical Wnt/Beta-catenin pathway BCL9 APC CTNNB1 PMC7601404__F1 Arginine biosynthesis NAGS ASL NAGK PMC9433876__F1 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response LATS1 LATS2 NF2 PMC9433876__F2 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response IFNG CXCL12 CSF1 TLR4 CXCL1 ARG1 CD163 SPP1 PMC9433876__F3 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response LATS1 LATS2 PMC9433876__F4 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response LATS1 BACH1 TRIOBP TRAF6 PMC2704571__F2 Diagrammatic representation of hormone therapy-induced changes in gene expression in the dorsal raphe block TNFAIP6 EGF UBC FAS DKFZp781O1323 TRADD KMO FAF1 TGFBR3 TNF BFAR TGFBR1 FGFR2 NGF MAP2K4 MAP2K5 TNFRSF21 BDNF APAF1 FADD PMC9116906__F2 Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets STAT3 CSA2 CDC37 TRAF2 PMC9423640__F2 Key genes pathway identification and potential drug design NR2A1 PAX4 NKX2-2 HEL-S-11 PMC8818874__F5 Confirmation of inhibitingTLR4/MyD88/NFKB Signalling Pathway by Duhuo Jisheng Decoction on Osteoarthritis: A Network Pharmacology Approach-Integrated Experimental Study STAT3 PPARG BAD PCNA SLC2A4 CYCS CCNA2 MAPK8 MYC CCL2 RUNX2 COL3A1 MPO PRKCB MAPK14 BIRC5 BCL2L1 PLAT COL1A1 ALOX5 F3 CHEK2 LDLR THBD CHUK MMP2 ALOX12 KDR CCNB1 CCND1 CDK4 MAPK1 HEL-S-117 BAX CASP8 SELE HK2 CXCL2 CXCL10 CYP1A1 FOS CDKN1A CDK2 MGAM MAPK10 PTGES HEL-75 PMC6107850__F1 Overview of RNA-sensing pathway TBK1 DDX1 MAVS NLRP3 TLR3 DHX36 DHX15 TANK IRF3 IRF7 PMC8314463__F1 Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice RHEB IPP HMGCR RHO PMC8901705__F1 Key therapeutic targets in the pathogenesis of autoimmune diseases CD40 CD80 APC JAK3 IL21R CD19 CTLA4 TNF ICOS GC JAK1 IL23R TYK2 IL1B PMC8884367__F3 Inhibitory Immune Checkpoint Molecules and Exhaustion of T cells in COVID-19 FYN LAG3 LCK PMC8409023__F1 Targeting the tumor microenvironment in chronic lymphocytic leukemia SYK BTK BCR ITK CD19 PMC2929918__F1 Homocysteine metabolism in the liver HEL-S-61p PMC6021530__F1 Regulatory functions of oncogenic and tumor suppressor miRNAs on canonical Wnt signaling pathways in HCC BMI1 CD44 BCL9 DKK1 APC WWOX NLK CTNNB1 RUNX3 PMC6996500__F7 Protein expression profile changes of lung tissue in patients with pulmonary hypertension RYR2 DMD DSC2 PMC12189131__F2 Metabolic effects of hydroxybenzoic acid derivatives on the coenzyme Q biosynthesis pathway COQ8B COQ8A COQ7 PDSS1 COQ3 COQ2 COQ9 COQ6 COQ5 PMC6996500__F8 Protein expression profile changes of lung tissue in patients with pulmonary hypertension PLN MYL3 MYH6 MYL2 DMD PMC9044593__F8 An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer ALDH2 NFYA PMC3759013__F1 Melanoma: New Insights and New Therapies AKT3 BRAF NRAS KIT BCL2 PTEN ME1 MTOR PMC3556327__F4 Cholesterol biosynthesis theme analysis ACADVL PMC7026586__F7 TP53BP1 and associated genes are downregulated in prostate cancer BRCA1 RNF168 RNF8 RIF1 TP53BP1 PMC2920482__F1 Detection of WNV and activation of IFNA/B genes and ISG according to the 2-step model IFNAR2 IFNAR1 IRF3 TRAF3 TYK2 PMC6209820__F5 Major pathways of cancer immunotherapy of Ganoderma in immune cells RCL1 F3 CD14 PMC9548376__F6 Autism-associated CHD8 keeps proliferation of human neural progenitors in check by lengthening the G1 phase of the cell cycle CBL EGFR CHD8 CDK2 PMC6920895__F5 The metabolic network and key enzymes in Aurantiochytrium sp FAS ACD PMC3877660__F1 An overview of EGFR and Wnt/Beta-catenin signaling DACT1 EGF TGFA PIM1 EGFR APC GSK3B LRP5 PTEN MTOR CTNNB1 CRK NEU2 GRB7 CBL EREG GRB2 CCND1 PMC5589252__F6 Mapping the STK4/Hippo signaling network in prostate cancer cell TP73 DVL1 SMAD1 TGFB1 PATJ RASSF1 FZD10 SMAD2 GSK3B FBXW11 SMAD4 BBC3 PPP2CA WTIP MYC APC2 TGFBR1 CTNNB1 LATS2 LLGL2 AFP YWHAQ AMOT NF2 CCND1 NKD1 SNAI2 CRB1 SOX2 AREG YAP1 gdf7 PRKCI WWC1 AXIN1 SCRIB CTNNA1 BIRC2 LEF1 PS1TP5BP1 PMC8745615__F2 Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins FLT3 MTOR USP9X PMC8745615__F3 Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins RFWD2 TRIB2 TRIB1 PMC9687758__F10 Genome-Wide RNA Sequencing of Human Trabecular Meshwork Cells Treated with TGFB1: Relevance to Pseudoexfoliation Glaucoma LATS1 SMAD1 AFP AMOT SMAD2 APC SOX2 SMAD4 PALS1 AREG PMC8156814__F5 Antitumor Activity of Nitazoxanide against Colon Cancers: Molecular Docking and Experimental Studies Based on Wnt/Beta-Catenin Signaling Inhibition CASP9 BAD APC CASP3 RHO CCND1 PMC6996500__F6 Protein expression profile changes of lung tissue in patients with pulmonary hypertension SGCB MYL3 IGF1 MYL2 DMD PMC5346542__F1 Metabolic reprogramming drives: (A) T-cell fate and function and (B) antitumor-immune response CD80 HIF1A CTLA4 MTOR MYC PMC11593441__F4 Signaling pathways regulating macrophage (Mφ) polarization STAT3 IL10 TIRAP CCR2 ARG1 IRF3 MTOR TRAF3 TRAF6 MYD88 STAT1 TLR4 NOTCH1 PMC10944288__F1 chemokine signaling pathway (hsa04062) as outlined in the KEGG database BAD PROC DOCK2 PMC10778864__F2 VEGF-VEGFR signaling pathway VEGFB VEGFC PIGF VEGFD VEGFA PMC8514798__F2 Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype STAT3 SOCS3 DUT PMC5309818__F3 Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions FUT3 URAD PMC11355545__F8 Schematic depicting the signaling pathway ROS/PARP/TRPM2 that causes SiNPs-induced lung inflammation in mice TRPM2 PARG SQSTM1 PMC10996061__F2 Impact of amotosalen/UVA treatment on phosphoproteome signaling and platelet pathways MAPKAPK2 HEL-S-102 MAP3K5 SRC MAP2K3 PMC11919857__F5 LncRNA-NEAT1 in cancer HMGA1 SOX9 MAK SULF1 KRAS PMC6966712__F8 Hypothesis of XIST/TSIX/PD-L1 regulation MTOR PMC4420606__F8 TLR3/TRIF mainly regulates IL-32-mediated pro-inflammatory cytokine and IFNB secretion through activation of RIP-1 and TRAF family proteins TBK1 TLR3 IRF3 IRF7 TRAF1 TRAF3 TRAF2 PMC4792590__F4 Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner BAX CASP9 BAD MSH2 SMAD2 APC CASP3 SMAD4 PMC8003462__F1 Physiological functions of the various kinases included in the PKR/p38/RIPK1 pathway BACE1 RIPK1 EIF2A PMC2929244__F6 Defects in physiologically driven actin signaling at hippocampal synapses in Fmr1-KO mice PSD ARHA SRC PMC4956564__F2 NFKB-mediated regulation of inflammatory and immunosuppressive CD4+ T-cell lineages STAT3 IL10 BATF TRADD NFKB2 CARD11 RELB IL6 TRAF3 TRAF6 GFI1 TBX21 MYD88 IFNG RORC MAP3K7IP1 BCL10 IL2 IL7 STAT4 FOXP3 TRAF2 CARD9 PMC4696186__F2 Molecular mechanisms linking ciliogenesis and cell cycle regulation CEP290 NEK1 KIF24 NEK2 OFD1 DAP NDE1 MARK4 INPP5E PLK1 HDAC6 PMC7397409__F1 ERS and unfolded protein response (UPR) ATF4 PMC3340722__F2 TNF related apoptosis-inducing ligand and its receptors in ocular tumors FADD PMC6203150__F1 Regulation and downstream effects of the Akt signaling pathway TSC2 BAD TSC1 PTEN MTOR PMC9392983__F7 miR-212-3p attenuates neuroinflammation of rats with Alzheimer’s disease via regulating the SP1/BACE1/NLRP3/Caspase-1 signaling pathway SP1 NLRP3 BACE1 PMC3313452__F4 The noncanonical NFKB pathway RELB TRAF3 TRAF2 PMC8007363__F7 Smad3-NOX4-derived ROS-mediated p38MAPK/Akt signaling in TGFB1-induced ECM production of HBSMCs CS NOX4 PMC2789488__F3 Schema of major signaling pathways involved in renal development (for space and clarity, not all factors in each pathway shown) KCP GDNF SHH SMO GRB2 CCND1 RET CTNNB1 GLI3 PMC10305525__F2 Three major H2S synthesis pathways are of enzymatic, non-enzymatic, and gut microbial origin ETHE1 DAO PMC2880522__F1 Results of a Pathway Studio® analysis of direct relationships between the components of the protein-bound fraction of renal cyst fluid ALB AHSG KRT1 SERPINC1 KRT10 HEL-S-62p APOH SERPINA1 PLG FGA PMC5730494__F6 Integration of signaling changes after the induction of BP1 FGFBP1 RAF1 RAC1 FGF2 CIT PMC11621238__F4 Mitochondrial dynamics and mitophagy in GBM cells KLF4 PINK1 MFN1 MFN2 RAB32 BNIP3 FAM72A DISC1 BCL2L13 PMC5388765__F1 An integrated network for phenylpropanoid regulation in the grape berry VIT MYB ERF PMC3194179__F4 Ingenuity Pathway Analysis identified NFKB as the Top Network signaling Hub where the shaded shapes indicate the candidate genes from the present study CTNND2 ANKRD1 PACRG KCNQ5 SPARC RASGRF2 RRAS KCNN2 NOD1 MAP2K5 OPTN SOX5 PMC3133912__F8 Bhlhb5 and the Notch signaling pathway DBX1 FOXN4 SHH OLIG2 LFNG PMC3194179__F2 Ingenuity Pathway Analysis identified ERK as the Top network signaling Hub where the shaded shapes indicate the candidate genes from the present study FER MGAT3 AKAP6 CTNND1 UCN3 PMC11825806__F7 Schematic diagram illustrating the effects of targeted activation of ErbB4 receptor on neuronal aging via ferroptosis inhibition ERBB4 GPX4 SLC7A11 PMC3194179__F3 Ingenuity Pathway Analysis identified MapK as second Top network signaling Hub where the shaded shapes indicate the candidate genes from current study TCF3 TCF12 ADAM19 PITX1 PAX5 GUCY2C GPRIN3 SRGAP3 PSAP TNIK FOXN3 PMC8529041__F7 Cancer Cell-Derived Exosomes Promote HCC Tumorigenesis Through Hedgehog Pathway SHH CCND1 PMC9492373__F9 Atractylenolide III Attenuates Apoptosis in H9c2 Cells by Inhibiting Endoplasmic Reticulum Stress through the GRP78/PERK/CHOP Signaling Pathway ELF2 ATL3 ATF4 PMC9201060__F7 Anti-Müllerian Hormone Signal Transduction involved in Müllerian Duct Regression TF SFRP5 SMAD1 APC LRP5 SMAD4 LRP6 CTNNB1 F2 WNT7A MMP2 AMHR2 AMH WIF1 PMC4773560__F1 Mathematical model of adrenal steroidogenesis in NCI-H295R cells CORT HSD3B2 CYP21A2 HSD17B3 CYP11A1 PMC5412458__F2 Ubiquitylating enzymes and deubiquitylating enzymes (DUBs) govern the outcome of TGFB signaling TRAF4 USP15 SMAD6 SMURF2 TRAF6 PMC3417348__F8 Proposed role of ER calcium underlying early disruptions in synaptic homeostasis at the CA3–CA1 synapse in AD RYR2 CA3 HEL-S-11 PMC4090103__F2 Virulence Strategies of the Dominant USA300 Lineage of Community Associated Methicillin Resistant Staphylococcus aureus (CA-MRSA) ARG1 ARC SPEG PMC4272565__F6 Breast cancer pathway ATR SMC1B BRCA1 H2AX AURKB ATM CDK3 BLM PMC9201060__F1 Anti-Müllerian Hormone Signal Transduction involved in Müllerian Duct Regression TF TH SMAD1 DKFZp781O1323 SMAD4 AMHR2 AMH PMC8461076__F7 Effect of MAP3K8 on Prognosis and Tumor-Related Inflammation in Renal Clear Cell Carcinoma ARAF ALK MAK STOM KIT SPG20 NF2 KIN PMC5826318__F1 Host-secreated miRNAs regulate the gut microbiota that in turn affects the host via induction of specific miRNAs STAT3 ABCG1 BCL2 PTEN ABCA1 PMC4063414__F3 Phosphoglycerate mutase 1 (PGAM1) controls the levels of allosteric regulators 3-phosphoglycerate and 2-phosphoglycerate PGAM1 HEL-S-304 RPIA PSAT1 PSPH PMC10943178__F10 The effects of EC‐EVs in sepsis‐related ALI/ARDS CD80 ITGA4 VCAM1 PMC9635865__F1 Recent advances in postoperative pulmonary rehabilitation of patients with non-small cell lung cancer (Review) PIK3CA GSTM1 TERT WNT3 MMP9 CTNNB1 PMC2433332__F3 T-cell polarizing factors STAT3 LAT JAK3 JAK1 TYK2 PMC5828008__F6 Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior CLDN11 NF1 GJB2 PMC11172800__F3 Significantly, DE genes (identified by KEGG) were involved in the bacterial invasion of epithelial cells signaling pathway during 8-week S CDC42 CAV2 ARHG ARPC5 PIK3CD HEL-S-28 DNM3 RHO SHE CTNNA2 CRK ITGB1 CD2AP WAS PMC7933196__F1 Berberine on diseases by regulating intestinal flora CD36 TLR4 CD14 MYD88 PMC5685854__F7 Pathway of VEGFR-2 (produced using the Pathway Builder Tool) VEGFC PXN VEGFA SRC PMC9139317__F5 Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma IDO1 KYNU KMO AFMID IDO2 PMC8138777__F1 Breaking androgen receptor addiction of prostate cancer by targeting different functional domains in the treatment of advanced disease TMPRSS2 CHKA PMC3908331__F9 KEGG mapping for cell cycle pathway MPL PCNA C2 MAL CDK2 CA14 PMC3868844__F6 Proposed signaling network involving mTORC2 and the p38 pathway EEF2K STAT1 ADRA1B GYS2 ATF1 MTOR FXYD1 XBP1 DEPTOR ATP11C PMC2988877__F2 DNA Damage Response: Making it safe to play with knives ATR ATM BLM PMC6460326__F1 HPV16 endocytosis and trafficking to multivesicular bodies CD151 CD63 PMC9167958__F7 Temperature and Growth Selection Effects on Proliferation, Differentiation, and Adipogenic Potential of Turkey Myogenic Satellite Cells Through Frizzled-7-Mediated Wnt Planar Cell Polarity Pathway FZD7 ARHA RAC1 PMC2988877__F3 The DNA Damage Response: Making it safe to play with knives ATR PCNA BLM PMC8534027__F2 Roles of Diacylglycerol Kinase A in Cancer Cell Proliferation and Apoptosis DGKA ARHA MTOR PMC5397843__F1 Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors CCND3 UBC PCNA RPL11 SKP2 VHL MDM4 CDKN2A SUMO1 CDK6 CDKN1A CDKN1B CREBBP CDK2 CDKN1C EP300 MDM2 CCND1 CDK4 PMC3683050__F11 Distinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle ECSIT JUN FAS RAG1 GRB2 NLK GCK TNF TRAF2 ERI1 PMC6921025__F1 Overview of PI3K-AKT signaling pathway CDCA2 RICTOR CRKL PTEN MTOR PMC4568771__F1 The Wnt/Beta-catenin signaling pathway and the oncology-indication drug candidates discussed in the paper BCL9 APC LRP5 LRP6 PMC2215765__F1 Schematic overview of the LPS TLR4 signaling pathway CD14 IRF3 TNF LBP IL1B MYD88 PMC7227439__F1 Role of metformin in VSMCs dysfunction PDK4 IFI16 MTOR SKP2 RUNX2 PMC4653031__F7 Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells IGFBP5 HIF1A IGF1R PMC8933845__F1 Immune Underpinnings of Barrett’s-Associated Adenocarcinogenesis: a Retrial of Nefarious Immunologic Co-Conspirators COX2 LIF IL1A IL6 TRIB3 IL1B PMC10866932__F7 SALL4 promotes cancer stem-like cell phenotype and radioresistance in oral squamous cell carcinomas via methyltransferase-like 3-mediated m6A modification CD44 SALL4 METTL3 CCND1 CTNNB1 PMC7563239__F1 Possible mode of action of matrikines on pulmonary arterial endothelial cells FAS ARHA MTOR FADD PMC2258259__F1 Metabolic pathways involved in pyrimidine metabolism DHFR UCK2 UMPS DHODH PMC11817128__F6 Target protein involved in NGF-NTRK1 signal transduction controls key protein targets NGF STAR COX2 NTRK1 GRB2 PMC7376370__F8 Proposed mechanism and pathway of RUT in suppressing DSS-induced IBD in mice HMOX1 MAF HEL-S-44 PMC10487967__F2 CGAS–STING pathway in cell death, autophagy, and senescence TBK1 CGAS MLKL IRF3 PMC3688698__F3 The mTOR Pathway in Hepatic Malignancies MTOR EIF4E PMC10487967__F3 Different roles of the cGAS–STING pathway in host defense and various diseases JUN CGAS IRF3 COPA PMC7545119__F1 Diagram of substrate utilization and suspected pathways in BAT LPL HMFN0839 CD36 SLC25A44 DGAT2 FASN UCP1 MPC1 MPC2 PMC3764828__F5 Model depicting mitochondrial generation of H2O2 as a key modulator of TCR-mediated signal transduction ZAP70 PLCG1 LAT APC GRB2 LCK PMC6724002__F6 Schematic representation a proposed pathway for hispidin-induced Nrf2/ARE-mediated cytoprotective proteins GCLM NQO1 GCLC PMC7216777__F1 Metabolic processing of bioactive lipids and their role in host immune response to infection TES LTB LOX PMC6591114__F1 Ze brafish as a model system to delineate the role of heme and iron metabolism during erythropoiesis CPOX STEAP3 FES PCBP1 ALAS2 FECH UROD UROS PMC3026990__F5 Signaling networks associated with PPARD and inflammatory and invasive gene expression CDC42 CASP9 MMP12 SELL EGFR NR1C2 CXCL2 MMP9 CXCL6 MPO FGF2 AGER IKBKB CASP3 MMP2 PMC5696077__F3 Biosynthesis and Structure-Activity Relationships of the Lipid A Family of Glycolipids STAT1 NLRP3 TIRAP IFNAR2 IFNAR1 IRF3 MYD88 PMC9598565__F3 Postnatal Conditional Deletion of Bcl11b in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington’s Disease PPP1R1B PPP1R18 CDK5 PAWR CALY CREBBP CAMK4 ATL1 SET PMC4970297__F6 Model summarizing the role of the HH signalling pathway and its primary transducer, GLI2, during mES cell cardiomyogenesis SHF MESP1 SUFU PTCH1 SMO TBX5 NKX2-5 GATA4 MEF2C GLI3 PMC5552241__F6 Proposed model of the Src/IGF-IR signaling axis present in both prostate cancer Exo and cells IGF1 SRC PMC8245769__F1 Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles NPAS2 PER2 PMC3713161__F7 Summary of the effects of increased dietary fat plus ethanol on the AMPK pathway and expression of enzymes involved in fatty acid synthesis ACLY HEL-S-5 HFE PMC4514171__F1 TLR diversity, ligands, and signaling TBK1 TLR1 TIRAP TLR3 TLR4 TLR9 IRAK1 TLR7 TRAF6 MYD88 PMC9630107__F3 Glucose metabolism proteins regulated by Src FYN F2 HK2 HEL-S-162eP SRC PMC3737583__F8 Working model for how ERA may modulate signaling by TLR-activated DCs PDC IL23R IMPACT IL1B PMC12114427__F2 Inducible expression pathway of Viperin MAVS IFNAR2 IFNAR1 IRF1 IRF3 IRF7 PMC9419932__F4 Estrogen Signaling Dictates Musculoskeletal Stem Cell Behavior: Sex Differences in Tissue Repair IGF1 EGFR PTEN ERG PMC9472457__F2 Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19 TMPRSS2 TBK1 CGAS MAVS IFNA21 IRF9 IRF3 IRF7 IRF2BPL MYD88 IFNG NLRP7 NLRP3 TLR3 TLR4 NOD2 TLR8 TLR7 TREX1 DNASE2 PMC5706812__F10 Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway AKT3 MTOR EIF4E PMC7686960__F6 Proposed model showing the suppressive mechanisms of Maackiain in RANKL‐activated NF‐KB and NFATc1 signalling pathways CTSK NFATC1 MMP9 ACP5 PMC9168169__F2 Advances in the study of RNA-binding proteins in diabetic complications JUND PDE3B PDX1 NLRP3 MFN2 MTOR HNRNPK ATG5 DDX3X IGF2 IL1B INSIG1 PMC3436188__F8 Interaction between Ryk and Wnt signaling pathways LRP5 LRP6 RYK ARHA CTNNB1 PMC3875403__F6 MDA-7 interferes with tumor promoting pathways GSK3A GSK3B PTEN PMC4230782__F9 The role of Pkp3 in cell–cell junction formation PKP2 PKP3 ARHA PMC8766833__F9 Quercetin Attenuates Podocyte Apoptosis of Diabetic Nephropathy Through Targeting EGFR Signaling BAX EGFR PMC8412840__F2 TGFB2 in cartilage development and diseases SMAD1 TIMP3 DKFZp781O1323 SMAD2 SMAD4 RUNX2 COL2A1 PMC9027975__F2 Interplay between Viruses and Host DNA Sensors IRAK1 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC11920683__F10 Schematic showing genes upregulated by ibudilast treatment during NMDA retinal damage on scRNA‐seq analysis SGK1 ULK1 TTI1 MTOR RHO DEPTOR IRS1 EIF4E RHEB MLST8 RICTOR TSC1 GRB10 IGF1 TBC1D7 GRB2 PMC9027975__F5 Interplay between Viruses and Host DNA Sensors TBK1 IFI16 IRF3 PMC5345336__F4 Notch signaling pathway DLL4 JAG2 DLL3 PMC8125679__F2 More Than Meets the Eye: Scientific Rationale behind Molecular Imaging and Therapeutic Targeting of Prostate-Specific Membrane Antigen (PSMA) in Metastatic Prostate Cancer and Beyond IGF1R SOX7 FLNA PMC3398238__F7 A ubiquitin-binding protein FAAP20 links RNF8-mediated ubiquitination to the Fanconi anemia DNA Repair network FANCD2 ATR RNF8 FANCM FAAP24 MDC1 PMC5769420__F4 Aurora kinase A and aurora kinase B interact with oncogenes to initiate tumorigenesis AURKA RALA BRCA1 PMC8820871__F4 Mechanistic Insights of Qingre Jiedu Recipe Based on Network Pharmacology Approach against Heart Failure MYB BAD FRK MAL POLI CYC1 PTEN PMC4258904__F2 Plasmacytoid dendritic cell as the Swiss army knife of the immune system: Molecular regulation of their multifaceted functions CD40 CD80 TLR9 IRAK1 IRF7 TRAF3 TRAF6 IRAK4 MYD88 BTK NAB2 TLR7 LAG3 PMC4841296__F1 Main molecular mechanisms affected in malignant megakaryopoiesis and platelet function defects MPL GP9 MYB NFE2 FLI1 GATA1 RUNX1 TUBB1 MYH10 MYH9 TPO CCND1 PMC2610259__F1 Chronic colon colitis model KEAP1 NQO1 MAF SFN PMC7014825__F6 JNK1-dependent IL-17 and TGFB signaling TGFBR2 IL17RC SMAD2 CXCL1 SMAD4 ATF2 IL11 IL6 TGFBR1 PMC6466002__F2 Duck RIG-I-like receptor (RLR) family signaling pathway MAVS TRIM25 OASL IRF7 PMC4629002__F4 Networks predicted by Ingenuity Pathway Analysis in Cmah-null mice PPARG NAT8 FMO5 STIM1 RGS16 HSD3B7 RXRG VAMP7 FBXO2 HSF2 STAT5B PARP2 GCK HEL-S-44 LPL ACOX1 APOE AIP HAMP G0S2 ALAS2 AQP8 HEL-S-94n CUX2 ANGPTL4 THRSP BTG2 NT5E HLA-B IL8RB ELOVL6 HEL-S-22 HEL107 EHHADH ASL LEP ITCH AACS IGF1R MEDAG IGFBP2 RHO TFRC RBP1 CSRP3 AHR MED13 SPON2 HSP90AB1 HEL-S-134P DDX3Y HEL-S-72p SERPINA12 GNAT1 EGR1 CRELD2 SGK1 H6PD PER2 CEND1 IVNS1ABP HBA2 FKBP5 RORC NR1C1 USP2 IKBKB LIPE INPPL1 ASNS PMC9292703__F1 Tryptophan‐derived serotonin‐kynurenine balance in immune activation and intestinal inflammation IDO1 KMO AANAT PMC10931026__F1 The polyamine synthesis pathway AMD1 SMS SRM SMOX PAOX PMC8866876__F4 Nrf2 Pathway in Liver Diseases CYP2E1 GSTM3 KEAP1 NQO1 SFN SQSTM1 SNX10 PMC8866876__F1 Nrf2 Pathway in Liver Diseases RBX1 KEAP1 GSK3B PMC6116371__F3 CircRNA and cancer-associated signaling pathways STAT3 EGFR SETDB1 PMC4620040__F1 Inflammatory bowel disease (IBD) as a multifactorial disorder STAT3 TNFAIP3 ARPC2 XBP1 TNFRSF6B CD1D SLC22A5 NLRP3 DLG5 TLR4 CCR6 NOD2 IL18RAP IL10 TNLG1B ATG16L1 LRRK2 ITLN1 IRGM DMBT1 TSLP PTGER4 IL23R IL12B CARD9 PMC8674839__F2 Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits RYR2 RYR3 ORAI1 STIM1 TRPC1 PMC4191659__F2 Receptor “hijacking” by malignant glioma cells: a tactic for tumor progression STAT3 EGF EGFR BCL2 SRC CXCL8 PMC4470795__F1 Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis ALDOB ENO2 HEL-S-133P HEL-S-68p HEL-S-49 HEL-S-162eP PC LDHB ENO1 PMC9272348__F3 Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease ACHE HEL-S-44 PMC3640280__F5 A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance IGF1 HEL-S-62p HEL-S-5 MTOR PMC7380956__F1 Accessory pathways of glucose metabolism: DAG1 FKRP PHGDH PMC3429879__F1 Therapeutic Mechanisms of Treatment in Cervical and Vaginal Cancer PNP TK1 PMC3641842__F1 The complement system C6 C7 SERPING1 HEL-S-62p VTN CD46 CD55 C4A CR1 MASP1 C2 MBP C9 C4B_2 PMC5887227__F9 ScRNA-seq profiling on progenitor cells and hPSCs PDPN SALL1 PLN NODAL MEF2C HOXA1 GDF3 CD24 AFP OTX2 TFAP2C TBX3 KDR HAND1 PAX3 SNAI2 PTN ECSCR TFAP2A CDX1 PRRX1 PAX6 HEL-S-78p FOS ID1 CD34 ARID5B ZIC2 PMC6345546__F1 Mechanisms of translation initiation currently known EIF3D ELF3 EIF4E PMC8268428__F2 Janus Face of IL-33 Signaling in Tumor Development and Immune Escape BAX IL33 SIGIRR IRAK1 CDK2 AREG TRAF6 IRAK4 MYD88 PMC8650690__F6 Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism IGF1 SMAD2 MTOR PMC4011666__F7 Calcineurin Signaling Regulates Neural Induction Through Antagonizing the BMP Pathway SMAD1 DKFZp781O1323 SMAD4 PMC9570443__F1 Pyroptosis and Insulin Resistance in Metabolic Organs GSDMD NLRP3 DFNA5 PMC3502876__F1 Reactive oxygen species-mediated autophagy regulation HMGB1 ULK1 UVRAG BNIP3 PTEN MTOR DEPTOR RHEB MLST8 TSC1 ATG12 HEL-S-2a ATM ATG5 ULK2 PMC7875152__F2 Genetic causes of PH SOX17 BMP10 BMPR2 ENG ATP13A3 ABCC8 TBX4 ACVRL1 KCNK3 AQP1 PMC8833412__F1 New Insights on the Genetics of Pheochromocytoma and Paraganglioma and Its Clinical Implications MAX FH CS EGLN2 SDHAF2 MERTK CSDE1 VHL EIF4E SDHD HRAS SDHA EGLN1 SDHB TMEM127 MAML3 NF1 FGFR1 MDH2 HEL-S-26 APAF1 SDHC RET PMC3518467__F1 Fast, Potent Pharmacological Expansion of Endogenous Hes3+/Sox2+ Cells in the Adult Mouse and Rat Hippocampus STAT3 GFAP HES3 MTOR PMC3731517__F6 Hepatic cholesterol synthesis and catabolism enzymes, uptake receptors, BA transport systems, phase II detoxification enzymes, and nuclear receptors investigated in this study UGT1A1 CYP8B1 CYP7A1 LDLR SULT2A1 CYP7B1 CYP27A1 PMC6038278__F1 Dysregulated genes and associated miRNAs in the KEGG TGFBeta-signaling pathway BAMBI IFNG RBX1 INHBA SP1 FST SMAD4 SKP1 NODAL ARHA TNF TGFBR1 PMC4264883__F4 Downstream Targets of Lmo4 Are Modulated by Cisplatin in the Inner Ear of Wistar Rats STAT3 STAT1 LMO4 NOX3 BRCA1 BCL2 JAK1 TYK2 PMC6038278__F2 MiRNA-mRNA associations involving genes in the KEGG TGFBeta-Signaling Pathway by location of action: extracellular factors (a), membrane receptors (b), and nuclear factors (c) RBL1 THBS1 TFDP1 TGIF2 MYC E2F5 PMC2733081__F4 MAPK Signaling Cascade is a Central Hub in the Regulation of Cell Cycle, Apoptosis and Cytoskeleton Remodeling by Tripeptidyl-Peptidase II INHBE E2F4 ITGA6 RPS6KA3 MYC PMC5137308__F7 Molecular mechanism for neurogenesis activated by 5-HT4 receptors by MOS CDC42 SPRY2 KIF26A GDNF MOS PTEN RHO GRB2 RET PMC9305276__F4 Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation MAVS NLRP3 IRF3 IL1B PMC3531289__F1 Chapter 3: Small Molecules and Disease PTER AEN PMC8866876__F5 Nrf2 Pathway in Liver Diseases LHB CYP2E1 KEAP1 SFN CCL4 PMC6321527__F5 Hypothesized mechanism of S5-induced death of human melanoma A375 cells EGFR CCNB1 PMC5141361__F3 Details of the PMF network model showing deregulated miRNAs and genes that participates to specific connected pathways, linked in turn to biological processes and functions germane to the disease ANGPT4 ARHGEF12 MISP CREBBP PTEN ARHA MTOR PMC3159301__F1 Pathways involved in platelet hyperreactivity in DM patients and therapeutic targets VASP COX1 GC IRS1 PMC8009526__F1 Signaling networks in inflammatory pathways and risk for suicidal behavior STAT3 IL10 JUN NFKB1 NFKB2 SI IL6ST TNF CEBPB FOS IL6R IL1B PMC7487062__F4 MDA-9/Syntenin/SDCBP: New insights into a unique multifunctional scaffold protein CDC42 STAT3 EGFR SMAD2 GSK3B HEL-S-28 IGFBP2 MMP9 VEGFA ARHA TGFBR1 CTNNB1 MMP2 SRC PMC4607655__F3 Metaproteomics Reveals Functional Shifts in Microbial and Human Proteins During a Preterm Infant Gut Colonization Case HEL114 VASP TIAM1 CGN CRB3 RAB13 STX4A PTEN CASK ARHA CTNNB1 PMC5283709__F3 A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2 C2 FRK TERT RET PMC3789261__F3 Pathways impinging specifically on glucose-mediated F-actin remodeling in the B cell CDC42 VAMP2 PAK1 PMC2858906__F1 Main steps and key regulators in blood and lymphatic vasculature development PROX1 SOX18 ETV2 PMC7920857__F8 Mechanism graph of the regulatory network and function of SIRT1 in aging of HEMECsSIRT1 restrains cell aging through GIRDIN phosphorylation via Akt signaling pathway IGF1 SIRT1 PMC11629350__F6 Neural graph network displaying the six signaling pathways that were detected as significantly regulated, along with the genes within these pathways that were significantly affected by mechanical loading (0 CACNB1 NCOR2 ARHGEF18 WHAMM AQP7 SLC2A4 PMC8650620__F2 In Sickness and in Health: The Oxygen Reactive Species and the Bone PTH RUNX2 NOX4 CTNNB1 PMC8426635__F7 Tricin Biosynthesis and Bioengineering CAD PRX PMC5480057__F4 Extended regulatory network to describe Nanog multistable dynamics in serum/LIF ESRRB KLF4 FGF7A SOX2 PMC6539579__F5 Roles of c-Myc in colorectal cancer (CRC) organoids PRDM1 CEMIP PMC6539579__F3 Regulation of Wnt/Beta-catenin/c-Myc signaling pathway APC TCF4 CCND1 CTNNB1 PMC5354887__F7 Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells BRAF KRAS IRS1 PMC11783064__F3 Molecular-signalling pathways activated by methamphetamine contribute to cardiotoxicity BAX FIS1 KEAP1 TAAR1 BCL2 PMC12065022__F7 Working model for the mechanism of quercetin on HCC BAX P4HA2 MTOR PMC9672399__F5 Tridimensional cell culture of dermal fibroblasts promotes exosome-mediated secretion of extracellular matrix proteins LTBP1 CSF1 SPARC NPTX1 NID2 F10 NPM1 PRELP HNRNPK FBLN2 TNFAIP6 APOD SERPING1 APOE HAPLN1 B2M TUBB RELN VCAN CTSO APOB ACLY PTX3 MMP14 HEL-S-62p LOXL1 IGFBP4 SRPX2 C4A RARRES2 CLU TPM3 GREM1 LDLR HABP2 APP NOTCH3 C4B_2 ITIH2 HEL-S-101 COL1A2 CFD FASN IL6 SFRP1 FNDC1 OLFML2B LOXL3 LOXL4 MFAP2 PTPRE HP CSPG4 PMC6371621__F1 The mechanisms of microRNA biogenesis and its regulation of gene expression AGO4 RAN DGCR8 AGO1 AGO2 DROSHA PMC7554303__F2 Various cell fates upon Mycobacterium tuberculosis infection TRADD CD36 IL1B FADD PMC8106603__F2 Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma MFN1 MFN2 EIF2A XBP1 PMC10539095__F2 Molecular Basis of Wnt/Beta-Catenin Signaling Pathways in Neurodegenerative Diseases F2 RYK RHO DAAM1 PMC8955937__F9 WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders HEL-S-133P HK2 HIF1A CS PMC8700745__F3 Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid–Base Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel Mechanism for a Co-Occurring Polyautoimmune Scenario VIT PTHLH SLC26A7 PTH2R PC PTH SST PMC3607103__F3 Recognition of nucleic acids by innate immune cells triggers cytokine production MAVS BCR TLR9 DDX41 AIM2 IRF7 TLR7 MYD88 PMC3284544__F4 Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis MAP3K7IP1 TIRAP TLR4 CD14 TRAF6 LBP MYD88 PMC3284544__F5 Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis HTRA2 TRADD TRAF2 DIABLO FADD PMC8941124__F7 Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells DRAM1 BMI1 BAX ULK1 BCL2 ATM MYC PACS1 PMC8572597__F7 Exploring the Effect of Jiawei Buguzhi Pills on TGF-Beta-Smad Pathway in Postmenopausal Osteoporosis Based on Integrated Pharmacological Strategy BAMBI SMURF1 THSD4 FST SMAD2 SMAD4 NODAL RHO SMURF2 TNF PMC9189138__F2 Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT CDH2 TGFB1 EPHA2 EGFR DDR2 LYN RHO CXCR4 SOX4 PMC3284544__F6 Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis IFNE MAVS TANK IRF3 IRF7 ISG15 RET UNK PMC6167446__F1 Pathogenic roles of NLRP3 inflammasome in liver diseases NLRP3 TXNIP TLR4 TLR7 IL1B PMC10926276__F5 Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRB/PI3K/AKT pathway MPG HEL-S-273 TXNIP SDC4 SCAI GMFB SUMO2 ZBP1 HAL GBP2 NUP58 MAPK1 HSD3B2 CAD ROCK2 SCD SNCA MOGAT2 HGS ENG ITGAM NECTIN2 GTF2B CDK5 UBE2B DDX47 GPNMB STX2 SAA4 MB ASNS CYP7B1 RTCA PMC3849943__F2 Network of the interactions of the miRNAs and their target genes (experimental observed or highly predicted) CD40 F11R MMP14 CSF1 TNFAIP3 TNFRSF10B NRP1 ST8SIA1 IL2RA SOCS3 MYC CCL2 ULBP2 TGFBR1 BCL2L1 PNP PTPRO TLR4 DPP4 IL18 TRIB1 COL4A1 CDH2 TNLG1B PIM1 TNFRSF9 TNFSF13 KLRK1 PLXND1 PTGS2 FOS TIGIT FTL SCG2 SCARB1 LPAR2 PMC3513881__F3 Proposed three pathways for the mechanism of nicotinic acetylcholine receptor (nAChR)-mediated survival signal transduction STAT3 FYN PMC4545436__F1 Signaling pathways involved in CSCs SAG APC PTCH1 GSK3B SHH SMO CTNNB1 PMC4423147__F8 The Nodal signaling pathway during establishment of the LR asymmetry in amphioxus DKK4 GDF3 FOXQ1 DKK1 LHX3 NODAL GDF1 DKK2 PMC3297581__F6 Tcf7 Is an Important Regulator of the Switch of Self-Renewal and Differentiation in a Multipotential Hematopoietic Cell Line CEBPE STAT3 JUN IRF1 NR1C2 ERG RUNX2 RORA CEBPA FLI1 RUNX1 HLF ELK3 REL PMC10540075__F8 Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights NRK NAPRT HEL-S-90n NMNAT1 KYNU KMO SLC22A3 NMNAT2 NAMPT SLC7A5 SLC12A8 SLC5A8 SLC36A4 NADK NMNAT3 PMC7595283__F1 Some like it hot: Candida activation of inflammasomes NLRC4 SYK NLRP3 EGFR IL1B CARD9 PMC6795182__F1 Cluster-1, cluster-2, and cluster-3, with molecular-targeted therapeutic options MAX EGF FH EGFR EGLN2 IRS1 CSDE1 CTNNB1 VHL HDAC1 EGLN1 TSC2 TSC1 TMEM127 MAML3 NF1 MDH2 PMC4599277__F7 Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-Beta-catenin signaling axis in a microRNA-34a dependent manner STAT3 APC GSK3B WNT1 CTNNB1 PMC6059011__F1 EV Biogenesis and Interaction With Recipient CellsExosome formation starts with endocytosis, a process in which the cell membrane is pinched inward and captures bioactive molecules, resulting in the formation of the endosome RAB27A RAB27B RAB7A RAB31 ARF6 TSG101 PMC8027612__F8 Protective effect of SAA on vascular permeability via inhibition of VEGFA-Src-MMP signaling pathway activation during acute ischemic stroke VEGFA CTNNB1 PMC4417677__F1 Cartoon illustration of the physiological roles and therapeutic implications of OCT1, SLC13A5 and ZnT8 in glucose metabolism, lipogenesis and insulin pathway TG OGDH SLC13A5 PMC8306901__F5 Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Germinoma CBL NF1 NRAS KIT PTEN MDM2 CTLA4 PDK2 MTOR KRAS PMC5416953__F5 Working model of the role of LXR in Fgf21 gene regulation in mouse liver during fasting HDAC3 POLL POLI DUX1 RORA PMC8215544__F4 Neddylation Regulates Macrophages and Implications for Cancer Therapy BAX WEE1 CDT1 ORC1L PMC4658613__F6 Insulin-like growth factor-1 signaling with regard to Helicobacter pylori associated glucose dysregulation IGF1 IGF1R IRS1 PMC11979393__F1 The apoptosis signaling pathway BAX TRADD BCL2 TRAF2 FADD PMC10181312__F2 Circadian clock system involved in regulating photoperiodic flowering in Arabidopsis, soybean, and rice PRR5 RFWD2 PRR9 RFT1 PRR7 EHD1 ELF3 PMC11853215__F7 Proposed simplified signaling pathway elucidating the mechanism underlying the amelioration of steatosis induced by Exendin-4 CDC2 GLP1R FOXM1 NR1H2 FAS MTTP ACADL CXCR4 PMC4609261__F1A Mapping the pathways of resistance to targeted therapies HRAS MTOR PMC5448109__F6 Simplified models of ribonucleotide excision repair in Eukarya (A), Archaea (B), and Bacteria (C) POLL FEN1 PCNA POLI PMC8106186__F1 Signalling pathways involved in CM, UM and MM oncogenesis, and regulation of HIF under hypoxia NF1 BRAF NRAS KIT PTEN MTOR CXCR4 PMC1913098__F1 Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control STAT3 LIF SOCS3 PMC4470795__F4 Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis GSTM3 HEL-S-21 GLS2 PMC3812980__F6 Proposed schema of how the BMP signaling axis limits neurogenic muscle wasting SMAD1 DKFZp781O1323 SMAD4 PMC8293747__F1 Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review GSDMD NLRP3 IL1B PMC8858079__F1 IGF cascade IGF2R BCL2 IGF1R GRB2 MTOR CCND1 IRS1 PMC10964526__F8 Potential pathways of exercise training to improve pulmonary function USP44 CCL3 FOXP3 MTOR TRPM8 PMC4506786__F4 Linear ubiquitination signals in adaptive immune responses SHARPIN TRADD OTULIN TRAF5 RIPK1 TNF CYLD TRAF2 FADD PMC11849352__F1 TLR3 signaling pathway TLR3 IRF3 TRAF3 TRAF6 PMC11103046__F1 Cardioprotective Mechanisms of SGLT2 Inhibitors Against Cancer Treatment–Induced CardiotoxicitySodium-glucose cotransporter-2 (SGLT2) inhibitors protect against cardiovascular toxicity induced by anticancer drugs via multiple mechanisms NLRP3 NQO1 ATF4 MTOR PMC4506786__F1 Linear ubiquitination signals in adaptive immune responses SHARPIN TRADD OTULIN TRAF5 TNF CYLD TRAF2 PMC9708627__F2 Interferon in systemic lupus erythematosus—A halfway between monogenic autoinflammatory and autoimmune disease PDC TREX1 PMC5563293__F2 Schematic presentation of the fusion-activated Ca2+ entry (FACE) CAD ORAI1 CD9 ADA PMC11103046__F2 The Anticancer Effects of SGLT2iSGLT2 inhibitors (SGLT2i) inhibit glucose uptake by inhibiting SGLTs (SGLT-1 and SGLT-2) and glucose transporters (GLUTs) FOXA1 TIMP1 EGFR SHH MTOR HNRNPK YAP1 PMC3378547__F5 Molecular Effects of Doxycycline Treatment on Pterygium as Revealed by Massive Transcriptome Sequencing SRPRB PDIA4 GMPPB SEC61A1 PPIB EDEM1 SEL1L ALG2 GLT8D2 XBP1 VCP PDIA5 SIL1 HYOU1 RPN1 STT3A DNAJB11 ATF4 WFS1 SSR2 PMC7554303__F3 Immunometabolic and bioenergetic changes in a macrophage infected with Mycobacterium tuberculosis CXCL9 CAD CD36 IL13 JAK3 IL4 MFF CXCL10 GATA3 MYD88 C2 COX2 JAK1 PMC7226825__F2 Anti-inflammatory roles of GFLs and their receptors following air pollution, allergy, bacteria or virus infections IL10 IF2B1 TGFB1 GDNF ARTN NRTN IL4 IL6 MPO CDA IL16 GFRA2 RET PMC3683875__F1 Nucleotide excision repair (NER) pathway ERCC1 XPA PCNA CPD XPC PMC3670291__F2 Roles of STATs signaling in cardiovascular diseases STAT3 GRB2 JAK1 SRC PMC8145016__F2 Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients NR1i1 FGFR4 FGF23 PMC3008633__F1 Examples of reaction–diffusion processes in muscle TNC PC CS MB PMC7555983__F6 MiRNAs, their related gene targets and cellular pathways likely involved in MFS aortopathy APC CCNA2 PMC7290605__F4 Schematic diagram represent the Putative mechanism of HPV in breast carcinogenesis NFX1 COX2 BRCA1 SRC PMC7659352__F13 Co-treatment with coffee decoction and tamoxifen markedly induces apoptosis by activating p53 in MCF-7 cells GREB1 BAX TFF1 HEL-S-130P PGR PMC6387651__F6 Proposed signaling pathways that regulate LSEC phenotype and crosstalk between LSECs and HSCs in normal and fibrotic liver EGF HBEGF CD36 EGFR ADAMTS13 CD47 PMC4082184__F2 Turning Off AKT: PHLPP as a Drug Target PTEN IRS1 PMC3911663__F5 Summary model for rAdV DNA sensing CGAS TLR9 DDX41 AIM2 IRF3 IRF7 MYD88 PMC9612852__F2 Intracellular checkpoint of IL-15 signaling in human or murine NK cells STAT3 FOXO1 JAK3 GRB2 MTOR JAK1 IL15RA XBP1 GAB2 PMC8704600__F1 Crosstalk between Statins and Cancer Prevention and Therapy: An Update BAX EGFR BCL2 RHO PMC3727904__F2 PATHWAYS IN MICROBE-INDUCED OBESITY IFNG LTBR PYY TLR4 TLR9 CD14 TLR5 IL1B MYD88 PMC4777532__F3 Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance GLDC TXNDC12 ACSM2B ABHD14A NAF1 CARNS1 GSTT2B GATF-C GLYATL2 PIPOX TYMS HEL-S-51e DAO ASPA NAGS SPTLC2 FYN NF1 GAD2 MTHFD2 NOS2 ALDH3A2 RELN DLD MTR TAF10 GLS VAMP2 DHFR GAD1 ACTN2 INS HYI PIG59 HEL-S-182mP AMT MTHFD1L OGDHL ARG2 GAL CAD TBL1X ARG1 CACNG4 HEL-S-70p MED1 PPY HEL-S-8a AGXT FOXA2 SNAP25 ASNS PMC9314626__F2 Metabolic dynamics instruct CD8+ T‐cell differentiation and functions CD80 TSC2 SLC7A1 TSC1 OPA1 APC MTOR MYC CPT1A PMC7865543__F3 Signaling pathways involved in regulation of and therapeutic avenues for targeting the LOX family LOXL2 BMP1 LOX LOXL1 SRC PMC10473154__F1 Understanding the Involvement of microRNAs in Mitochondrial Dysfunction and Their Role as Potential Biomarkers and Therapeutic Targets in Parkinson’s Disease TFAM PINK1 OPA1 LRRK2 MFN1 MFN2 SNCA NRF1 PMC7263916__F4 Avian leukosis virus subgroup J and reticuloendotheliosis virus coinfection induced TRIM62 regulation of the actin cytoskeleton ABI2 HEL114 TG PXN F2 APC RHO INS DOCK1 PMC8949402__F2 Immune Escape Mechanism and Vaccine Research Progress of African Swine Fever Virus CGAS TLR3 PMC7187988__F2 Hormonal control of adipocyte lipolysis PDE3B ABHD5 PLIN1 GC ABHD15 PNPLA2 FAP IRS1 PMC6780086__F6 Transcriptional profiling of enzymes involved in type II fatty acid synthesis (FASII), glycerolipid synthesis in plastid (GLSp) and cytosol glycolysis (GLSc), and beta-oxidation TG GAL FAS PC PMC5777172__F2 Regulation of hepatic glucose metabolism in health and disease PDE3B INSR GCGR GCK PMC5729931__F5 Enhanced AMPA receptor trafficking mediates the anorexigenic effect of endogenous glucagon like peptide-1 in the paraventricular hypothalamus GLP1R NTS PSD CRH PMC5431987__F5 Ingenuity Pathway Analysis cancer network from RNA-Seq breast cancer samples HCAR2 NRG1 EGFR CASP3 PRNP ZEB2 BCL6 NEDD9 PMC8369345__F1 Role for Frizzled and Their Post-Translational Modifications in the Mammalian Central Nervous System APC GSK3B LRP6 RYK RHO CTNNB1 PMC12106438__F2 Molecular mechanisms of intracellular lactate production and export GLS HEL-S-133P PDC PMC12106438__F3 Effects and mechanisms of lactate on macrophage polarization HMGB1 GPR65 HK2 ARG1 HIF1A MPC1 PMC3379693__F1 Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut TBK1 TIRAP TLR9 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 TLR7 PMC7187988__F5 Adipocyte lipolysis is implicated in disease such as diabetes, fatty liver disease and cancer FAS PLIN1 PC G0S2 IL1B PMC8012622__F5 Formation pathway of cytoskeleton structure by F-actin CDC42 ARHA RHO RAC1 PMC5356911__F1 Extracellular vesicles in mediating progression, metastasis and potential treatment of hepatocellular carcinoma MAP3K7IP1 TAB3 TRAF6 UNK PMC5226619__F3 Inflammasome: an emerging therapeutic oncotarget for cancer prevention STAT3 STAT1 TNF PMC8093981__F1 14‐3‐3 proteins in cell signalling pathways and virus infection TSC2 BAD PMC8093981__F2 14‐3‐3 proteins in cell signalling pathways and virus infection TLR1 TRIM25 TIRAP TLR4 IRF3 IRF7 PMC7163447__F9 Proposed model for the role of mitochondrial biogenesis process in developmental fluoride neurotoxicity and protective action of RSV TFAM NRF1 SIRT1 PMC2784025__F8 Proposed model of the underlying mechanism by which NeuroD6 may bridge neuronal differentiation to survival CASP9 CASP3 APAF1 NEUROD6 PMC5479446__F1 Schematic view of UPR response in mammals ATF4 EIF2A XBP1 TRAF2 PMC10534925__F3 Epidermal Growth Factor Receptor-Targeted Neoantigen Peptide Vaccination for the Treatment of Non-Small Cell Lung Cancer and Glioblastoma CD80 FAS PMC7736222__F2 PGC-to-ProSG-to-SG transition ETV5 CDC2 LHX1 CD82 NANOS3 KIT DAZL STRA8 MKI67 PGC CDKN2A NR1B3 ELMO1 PALLD POU5F1 ID4 ETV4 DNMT3L PIWIL4 UTF1 PMC11522757__F1 Regulated cell death (RCD) pathways implicated in pathological cardiac hypertrophy RIPK3 BAX GSDMD NLRP3 LPO MLKL GPX4 MTOR TNF ULK2 PMC10571577__F3 Acquired mechanisms of resistance to MET-Is EGF NRG1 EGFR BRAF KRAS PMC10571577__F1 HGF/c-MET signaling pathway ROR1 CD44 STAT3 HGF EGFR MST1R GRB2 MTOR CTNNB1 PMC9228484__F1 Virus–Host Interplay in Junín Mammarenavirus Infection HDC PMC3857020__F10 Proposed functions of Spry1 and Spry2 in regulation of eyelid closure SPRY2 CCND2 SHH FGF10 CCND1 SPRY1 FGFR2 PMC9228484__F2 Virus–Host Interplay in Junín Mammarenavirus Infection ARF1 TSG101 IMPDH2 VPS4B VPS4A PMC7910064__F5 Schematic figures of metabolic alterations in HCC TG FAS NR1C1 CD36 HEL-S-26 PMC6498733__F1 Beta-adrenergic signaling pathway in prostatic cancer BAD ENO2 PAK4 BCL2 ARHA HDAC2 PMC8190251__F3 Longevity pathways in stress resistance: targeting NAD and sirtuins to treat the pathophysiology of hemorrhagic shock NMNAT1 NAMPT NMNAT2 SIRT1 NMNAT3 PMC8105194__F1 Endocannabinoid and dopaminergic system: the pas de deux underlying human motivation and behaviors DAGLA SAG FAAH PMC12167312__F1 Developmental neurotoxicity induced by anesthetics targeting GABAARs BAX BACH1 TLR4 MTOR BDNF TRAF6 MYD88 PMC6997384__F1 Erythropoietin and its derivatives: from tissue protection to immune regulation STAT3 CCL11 CCL3 CD36 CXCL1 JAK3 EPO ARG1 CCL2 MERTK TPR MFGE8 JAK1 CEBPB PMC12167312__F2 Effects of anesthetics targeting GABAARs on different neuronal populations BDNF TNF PMC12167312__F3 Neuroprotective mechanisms of NAS BAX TIRAP TLR4 GPER TLR7 TRAF6 MYD88 PMC5618308__F1A Unlocking the NFKB Conundrum: Embracing Complexity to Achieve Specificity MAP3K7IP1 TRADD TAB3 RELA TRAF5 TRAF6 TRAF2 IRAK4 MYD88 PMC6997384__F2 Erythropoietin and its derivatives: from tissue protection to immune regulation SOCS1 STAT3 TPR TLR4 TLR9 IRAK1 EPO TRAF6 IL1B MYD88 PMC6997384__F3 Erythropoietin and its derivatives: from tissue protection to immune regulation POR TPR IL2RB APC EPO IL2RA GRB2 JAK1 PMC2997007__F5 Candidate master switch molecules and signaling pathways involved in LPS-induced inflammatory response of monocyte THP-1 cells SYK IL10 TNFRSF10C EGR1 ITGA4 OSM TNFRSF10B SP1 SELE CCR5 CD14 ATF2 ITGB3 KITLG CTNNB1 STAT1 ITGA2 RELA BCL2 VCAM1 TNFRSF11B SELP IL1B PMC2997007__F6 Identification of putative signaling regulators for immune-modification TNFRSF10C SP1 NGFR YY1 KITLG MPO STAT1 ITGA2 RELA BCL2 CXCR4 TNFRSF11B SELP PMC9485555__F8 Exercise inhibits JNK pathway activation and lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease ACOX1 BAD FAS CD74 CD36 BCL2 MIF PMC7365992__F3 Extrinsic pathway involves transmembrane receptor mediated interactions FAS FADD PMC7365992__F4 Apoptosis and genes involved in oral cancer - a comprehensive review BAD CAD AVEN DIABLO PMC8493690__F5 Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway LATS1 LATS2 YAP1 PMC11591633__F5 Pharmacological modulation of NCC function in the DCT CASR WNK1 WNK4 SGK1 KLHL3 OSR1 PMC11591633__F3 Post-translational modifications regulating NCC activity in the DCT WNK1 WNK4 CAB39 KLHL3 OSR1 PMC11591633__F4 Physiological stimuli that modulate NCC activity CORT WNK1 WNK4 SGK1 KLHL3 OSR1 INS AVP PMC11598704__F3 Role of deubiquitinating enzymes on the cell cycle in GC USP35 LATS1 LATS2 USP3 USP12 OTUD7B OTUD5 USP20 USP37 USP9X USP29 USP49 PMC4628672__F3 Pathways analysis of the proteins listed in by means of the Ingenuity software CASP9 HEL-S-67p BCL2 APAF1 PMC2954727__F1 Working model of the effects of E2 on cell migration VAV2 EGFR NODAL ARHA SRC PMC6942871__F6 The main targets of miR-221/222 involved in ovarian cancer STAT3 ARF4 PTEN BMF SOCS3 PMC4454164__F7 Proposed mechanism for RSV in the regulation of mtROS homeostasis through Sirt3 signaling pathway in HUVECs SIRT3 ROS1 PMC3405730__F2 IL-2 signals by activating three principal signaling pathways, the SHC/RAS/MAP kinase pathway, JAK1/JAK3/STAT5 pathway, and PI 3-K/AKT/p70 S6 kinase pathway TF IL2RB JAK3 IL2RA GRB2 JAK1 PMC4765995__F1 Polyp to colorectal cancer sequences OMP SMO KRAS PMC7427429__F3 Pathogen-derived molecules enabling VP22 to evade the DNA-sensing pathway in cells TBK1 CGAS AIM2 IRF3 IL1B PMC7663815__F11 Crosstalk between androgen and Notch signaling pathways in rodent Sertoli cells GC HES1 NOTCH1 PMC8303459__F1 MEK5/ERK5 Pathway in Health and Disease KLF4 KLF2 PAK1 PMC9256747__F2 Molecular mechanisms underlying suicidal NETosis and vital NETosis COX2 TLR4 IL8RB MPO PMC6520938__F1 Canonical Wnt signaling pathway APC GPR49 CCND1 PMC8116282__F3 Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry GOT2 FH IDH3B EGLN2 SDHAF2 VHL SDHD SDHA SDHB SLC25A11 MDH2 HEL-S-26 SDHC PMC6520938__F2 Canonical Notch signaling pathway CDKN1A FURIN CCND1 PMC12131388__F6 Drug-pathway-target-disease network of ATBC in ovarian damage (A) and infertility (B) PPARG MCL1 IGF1R PTGS2 TNF KRAS MAPK14 HDAC1 STAT1 BCL2L1 NFKB1 TLR4 CASP3 NFE2L2 MMP2 IL2 BCL2 ATM SRC PMC8265496__F4 Necrotizing lymphadenitis may be induced by overexpression of Toll-like receptor7 (TLR7) caused by reduced TLR9 transport in plasmacytoid dendritic cells (PDCs) PDC TLR9 IRAK1 IRF7 TLR7 TRAF6 IRAK4 MYD88 PMC7532258__F8 HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3B/Beta-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats GSK3B LRP6 CTNNB1 PMC9216203__F1 Secreted proteins positively related to bone homeostasis and baseline Vo2max SMOC1 COMP NOG COL9A1 EPYC CRTAC1 PMC7067140__F1 DYSREGULATION OF METABOLIC ENZYMES IN TUMOR AND STROMAL CELLS: ROLE IN ONCOGENESIS AND THERAPEUTIC OPPORTUNITIES ACLY FH GLS HEL-S-162eP FASN CS MYC GDA PMC11682976__F1 Angiogenesis and EMT regulators in the tumor microenvironment in lung cancer and immunotherapy VEGFC PDGFRA EPO VHL PMC6169812__F1 New interactors of endothelial adherens junctions (AJs) HEG1 RASIP1 TRIO RAB11A RHO SRC CTNNB1 PMC3938851__F1 Insulin/IGF-1 signaling and regulation RHEB TSC2 GRB10 TSC1 IGF1 ULK1 IRS1 PMC4426861__F1 Pathogenesis of Aortopathy in Marfan Syndrome and Related Diseases TF PLAT TRAF6 TGFBR1 PMC6338075__F5 Rhythms of life: circadian disruption and brain disorders across the lifespan TH CCK SIRT1 MAOA PMC4739352__F9 Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90 MADD BAD TRADD IGF1 RIPK1 APAF1 PMC2673547__F8 Oncogenic Function of ATDC in Pancreatic Cancer Through Wnt Pathway Activation and Beta-catenin Stabilization APC GSK3B CTNNB1 PMC12155930__F6 Anti-Inflammatory Activity of Thymol and Thymol-Rich Essential Oils: Mechanisms, Applications, and Recent Findings ROCK2 FHOD1 ROCK1 PTEN ARHA TNF PMC4850137__F1 Reactions induced by IL-10 CD2 MAFA RELA NFKBIA CHUK MTOR ACACA PMC8303459__F3 MEK5/ERK5 Pathway in Health and Disease CDC42 KLF4 KLF2 PAK1 MSC PMC7816678__F3 Diversity in stimulus sensing, fuel sources, and thermogenic mechanisms of brown and beige adipocytes TG CD36 SLC25A44 UCP1 SLC7A5 PMC7432891__F1 Schema of the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway and its regulators and effectors JUN SP1 EBP BCL2 APP GRB2 FOS PMC5743035__F8 Oxidative Stress in HIV Infection and Alcohol Use: Role of Redox Signals in Modulation of Lipid Rafts and ATP-Binding Cassette Transporters HMGCR DHCR7 HEL-S-64p PMC9510596__F1 Tryptophan metabolites in depression: Modulation by gut microbiota KYNU KMO AANAT ASMT PMC5468003__F5 Network analysis obtained from IPA of differentially regulated proteins (p ≤ 0.05) between recurrence (R) and recurrence-free (RF) patients STAT1 ADAR TAPBP RAB1A USO1 PML MYO9B RNF213 PMC3845579__F1 Regulation of mammalian target of rapamycin (mTOR) by the LKB1/AMPK signaling pathway RHEB TSC2 TSC1 PTEN MTOR PMC7833367__F2 Biphasic role of wnt/Beta-catenin pathway in heart muscle development MESP1 DKK1 CTNNB1 PMC4171766__F2 Top networks observed in Ingenuity Pathway Analysis (IPA) ENDOD1 HECTD1 ASXL1 TSC22D3 SHE RPS11 ZNF331 SRCAP CTCF TIEG2 ERMAP TACC1 CDA NAB1 PMC8478550__F3 Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases NLRP3 SMAD2 SMAD4 NOX4 PMC8478550__F1 Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases NLRP3 IL13RA1 SMAD2 JAK3 SMAD4 ATF2 TNF TYK2 PMC8182936__GA Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway NLRP3 IL1B PMC8478550__F2 Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases NLRP3 SMAD2 SMAD4 PMC4159950__F2 MicroRNAs As Biomarkers For Clinical Features Of Lung Cancer EZH2 PTEN MYC PMC5833693__F6 Glucocorticoid-induced apoptotic signaling pathway BAD GC BCL2 GRB2 PMC5351412__F1 Differentiation potential of mesenchymal stem cells BMP2 MSC MTOR PMC11225869__F1 In alveolar general capillary endothelial (gCap) cells, IGFBP7 prevents FBXW2-dependent ubiquitination and degradation of NFKB1/2 FBXW2 NFKB1 IGFBP7 PMC8583721__F2 Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases SMAD2 SMAD4 PMC5702042__F8 Suggested model of activation of the NLRP3 inflammasome by Fonsecaea pedrosoi hyphae in macrophages SYK NLRP3 IL18 IL1B PMC3867791__F6 Regulated in DNA Damage and Development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1) TSC2 TSC1 ULK1 ATF4 EIF2A PMC3823475__F2 Membrane VEGF receptors expressed by astroglial tumour cells PIGF GC KDR PMC3828821__F1 How does the metabolism of tumour cells differ from that of normal cells TH CA12 HEL-S-133P HK2 FASN MAL GLS2 CA9 CPT1A PMC9367238__F2 Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer RB1 SMYD2 MDM4 CCNE1 MAPKAPK3 PTEN MDM2 PMC4294653__F12 mTOR signaling pathway regulated by PLB in PC-3 cells.Notes: PC-3 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis RPS6 EIF4B RAN ULK1 HIF1A RHO IRS1 EIF4E TSC2 RICTOR TSC1 INSR PC ELF3 PMC6289345__F5 The proposed metabolic pathway of cryptotanshinone in HLMs CYP1A2 CYP2A6 UGT1A9 CYP2C19 UGT2B4 CYP3A4 UGT2B7 PMC5058685__F7 Hypermethylated in cancer 1(HIC1) suppresses non-small cell lung cancer progression by targeting interleukin-6/Stat3 pathway STAT3 HIC1 MMP2 PMC4294653__F13 mTOR signaling pathway regulated by PLB in DU145 cells.Notes: DU145 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis RPS6 EIF4B RICTOR INSR ULK1 HIF1A ELF3 IRS1 EIF4E PMC4036317__F11 How PLCG1 regulates USP1 phosphorylation to mediate 20E-induced gene expression for metamorphosis PLCG1 USP1 PMC9600272__F2 Emerging Role of ERBB2 in Targeted Therapy for Metastatic Colorectal Cancer: Signaling Pathways to Therapeutic Strategies TF TBK1 EGF SOS2 GRB2 MTOR VEGFA MYC PMC4294653__F11 PLB regulates apoptosis signaling pathway in PC-3 cells.Notes: PC-3 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis HTRA2 BAX BIRC6 BAD FAS CAD MCL1 CYCS BCL2 APAF1 DIABLO PMC3392173__F1 Wnt signaling pathways SOSTDC1 DKK1 APC RHO SRC LEF1 WIF1 CTNNB1 PMC4337883__F2 Choline metabolism in malignant transformation SP1 CHPT1 PMC4394890__F2 MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction MAX STAT3 RFX5 SMAD4 PTEN TCF4 YY1 MYC CTCF ZNF283 ZBTB7A TBP CEBPB JUN EGR1 SP1 LIF VEGFA FOS ESRRA RBX1 CEBPA NPPA RELA BCL2 PMC4394890__F5 MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction GATA2 JUN EGR1 COL1A2 RAF1 SP1 MCL1 SMAD2 SMAD4 PTEN VEGFA YY1 MYC TGFBR1 COL1A1 C2 BCL2 PMC11098157__F1 Metabolic pathway for S‐warfarin UGT1A1 CYP2C9 CYP3A4 PMC10568316__F2 Mφ-related inflammatory signaling pathways in NEC HMGB1 GSDMD NLRP3 TLR4 IRAK1 TRAF6 TNF IRAK4 MYD88 PMC8568295__F9 Hub gene multi-factor regulatory network NR1i1 KLF4 WT1 ITGAM FPRL2 RUNX1 SP1 C3AR1 SP3 SP2 KLF5 SPI1 PMC7242393__F10 Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics PGAM5 IRF3 MTOR PMC10568316__F1 Multifunctional role and mechanism of IMφs in NEC pathogenesis IGF1 CXCL5 BMP2 ARG1 TNF PMC3651771__F1 Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1RAvB3 integrin complex in tumorigenesis and angiogenesis IGF1 IGF1R SDC1 PMC4326712__F2 Simplified synopsis on the PI3K-AKT and RAS-MAPK signaling pathways and their interactions RHEB BAX GRB2 MTOR GAB2 PMC7010853__F8 Speculatively schematic diagram of this scientific hypothesis including the most significant SF (CLEF5), OS-SEs (GSG1L|35698|AP, GSG1L|35696|AP) and downstream pathway (Primary bile acid synthesis) CELF5 PMC8766727__F6 USP14: Structure, Function, and Target Inhibition USP14 NOTCH1 CTNNB1 PMC7685564__F1 Cross-Kingdom Activation of Vibrio Toxins by ADP-Ribosylation Factor Family GTPases ARF1 ARF6 CFTR CPD PMC8185986__F2 F ig . 2.Mϕ regulation of PMN chemotaxis ADRBK1 TLR4 IL8RB PMC3904428__F1 Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target RALA RALBP1 PMC7967180__F1 The leukotriene signaling pathway LTB GPR17 LTA PMC8349014__F1 Flavonoids on diabetic nephropathy: advances and therapeutic opportunities RHEB BAX MTOR PMC10968226__F2 TRPV4 channels in osteoarthritis ACAN SOX9 TNF PMC7582185__F4 Transcription factor CREB1 exhibits an opposite regulation in the downstream genes between WT and VCP TG mice in response to 2W TAC MYC GRIK2 OTOF INHA MIDN NEXMIF ARFGEF3 IER2 SORCS3 GAD2 KCTD4 TIPARP CHRNA1 CALCB LYPD6 PLCXD2 NNAT SLC17A6 TAFA1 XKR4 PNMT FOS HPGD EGR2 HLA-A KLF4 ZFP3 CYR61 LEP GEM GAD1 ARC VCP COL24A1 SSBP2 CTNNA2 HLA-DRA REN CEBPD HEL-S-14 FOXP3 IL1B CDH10 GAL JUN SMS TACR3 MKI67 TG PRL MUC2 APOLD1 PMC6529853__F5 Dysfunctional subpathway (path:04020_1) of calcium signaling pathway in CESC GNA14 AVPR1A TACR2 EDNRA EDNRB PTGFR PMC9368906__F4 LncRNA H19 Impairs Chemo and Radiotherapy in Tumorigenesis CD44 CTNNB1 PMC7711540__F5 Validation and pathway analysis of elevated S100A8 protein in FSHD SKA2 JUN PFN1 PANK3 TMEM245 S100A8 KRT16 FOS HUWE1 IGF1 TLR4 HEL-S-108 TMSB4X PROC S100A9 ATP11C HEL-S-15 TMSB10 PMC7830067__F1 Metformin enhances CD8+/CD4+ ratio to favor an immunoreactive microenvironment IFNG FOXP3 MTOR TNF PMC11831438__F10 Scheme depicting the proposed mechanisms for the neuroprotective effects of Tat‐Nrf2 peptide treatment in ischemic stroke GCLC SENP6 PMC7416697__F7 ABCC4 function in SHH signaling SUFU PTCH1 SHH SMO GLI3 PMC3571350__F10 Schematic model of IFN-induced apoptosis in WISH cells STAT1 CASP8 STAT2 IRF9 CASP3 JAK1 TYK2 FADD PMC11014460__F1 Responses of HIFs to hypoxia or hyperoxia HEL-S-68p EPO VHL PMC5081117__F6 Targeted transcriptomic analysis EHHADH HMGCL ASL ALDH18A1 AANAT DBT DAO AMD1 HEL-S-29 HEL-S-5 BCAT2 HAAO AADAT GOT2 CAD MTAP HEL-S-133P KYNU ENOPH1 AGMAT HEL-S-8a TDO2 IDO1 LAP3 HEL-S-61p APIP MTR PMC9247101__F5 Targeting fibrosis: mechanisms and clinical trials TGFBR2 EGF SMAD2 SMAD4 TGFBR1 PMC7202451__F5 Gene expression in the actin cytoskeleton signaling pathway for the hepatic transcriptome of S CRK FGD1 PXN APC GNG12 GRB2 SRC FLNA LBP PMC4462367__F2 Schematic diagram of the signaling of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway involved in human cancers TSC2 BAD RICTOR TSC1 INPP4B EGFR GSK3B PTEN MDM2 CCND1 EIF4E PMC7202451__F6 Gene expression of the ILK Signaling pathway in the hepatic transcriptome of S KRT18 HEL113 PXN RSU1 PTEN MMP9 MTOR RHO MYC NCK2 FOS RICTOR COX2 BMP2 CASP3 NACA PMC10419859__F2 ATX/LPA signaling pathway in different inflammatory diseases LPL LPA RHO PMC7202451__F7 Gene expression of the signaling by rho family GTPases pathway in the hepatic transcriptome of S PKN1 CRAT GFAP CYFIP1 PARG PMC4462367__F1 Schematic diagram of estrogen receptor (ER) signaling SP1 PTEN MTOR PMC3097472__F1 Methionine, an essential amino acid required for protein synthesis, is the source of methyl groups for a number of methylation reactions such as methylation of nucleic acids, proteins, biogenic amines, phospholipids, and for creatine synthesis etc HEL-S-61p PMC7549162__F6 Comprehensive network construction of crucial signaling pathways and DEGs associated with HBV-ALF ICAM2 HLA-DMB SYK CD244 SOS1 HLA-DRB1 HLA-DOA HLA-DQA1 TAP1 CTSS HLA-DPB1 HLA-DPA1 HLA-DMA HLA-DRA PRF1 HLA-E TYROBP HCST FCER1G HLA-B HLA-A LCK PMC2882734__F6 Pathways of VLC-PUFA biosynthesis ELOVL4 ELOVL3 ELOVL2 ELOVL1 ELOVL5 PMC9054177__F1 Molecular Basis of the Effect of Atorvastatin Pre-treatment on Stem Cell Therapy in Chronic Ischemic Diseases – Critical Limb Ischemia BAX BAD IGF1 HIF1A RHO MTOR IGF2 VHL PMC11969464__F2 Ingenuity pathway analysis of differentially enriched proteins RASGRF1 BAD RAF1 VAMP2 CTNND1 BRAF MARCKS FARP1 MTOR MAPK14 CLASP2 TLN1 HEL-S-15 APOE PLG ERC2 DLG4 RELN CRK SYNGAP1 CDK5 AFDN RAPGEF1 SNAP25 BDNF PMC10144233__F1 Heme b biosynthesis pathway HMBS MAL UROD UROS CP CIT PMC11969464__F3 Visualization analysis of pathways identified from normalized, significantly differentially-SUMO-enriched proteins AMPH BSN RAB3C LETM1 SYNPO HOMER1 EIF3K ARF1 MAP4 ERC2 EIF3A BRSK1 PTPN11 ACTN2 FLJ10842 DAP3 EPHA4 RAC1 RHEB SYT7 GSK3A RTN4 PMC4890990__F1 Molecular mechanisms of long noncoding RNAs on gastric cancer STAU1 KLF2 IGF2BP1 CDK6 RUNX1 SP1 E2F3 BCL2 MTOR CALN1 TINCR PMC10144233__F2 Formation of uroporphyrinogen III (UPG III) and the branching of the heme b biosynthesis HMBS SHD UROD CPD UROS PMC11514755__F8 NF-kappaB signalling pathway CD80 TIRAP CD14 IRAK1 IL6 TRAF6 IRAK4 MYD88 COX2 TLR4 TRAF1 VCAM1 TRAF2 LBP PMC7016717__F3 Oncogenic activation of the STAT3 pathway in T-cell lymphoma STAT3 JAK3 JAK1 PMC7016717__F2 Janus kinase 1 (JAK1)/STAT3 signaling in DLBCL STAT3 JUN BATF EGR1 SGK1 MEF2B BCL2A1 NFKB2 MCL1 SOCS3 IRF4 MYC MYD88 NFKBIA BCL2 JAK1 NFKBIZ PMC9240244__F7 Working model of the protective effects of Rb1 against D-GalN/LPS induced ALI: Rb1 inhibition of the TLR4/MyD88/NFKB signaling pathway and NLRP3 inflammasome activation RB1 NLRP3 MYD88 PMC9570477__F7 An Integrative Transcriptional Network Revealed Spatial Molecular Interplay Underlying Alantolactone and Inulin Biosynthesis in Inula racemosa Hook f. STS SST PMC2908475__F2 The intracellular signaling network regulating T-cell trafficking and differentiation IL15 IL-21 SELL CCR7 IL21R IL2 PTEN BCL6 PMC6719725__F6 Assessment of network module identification across complex diseases HTRA2 GRAP2 IL17F SLA LAT CTLA4 HTRA4 TFF3 MPO POR STAP2 TFF2 RICTOR GRAP RELA STAT4 REL RETNLB PMC5824497__F2 NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning NRK SIRT7 NAPRT HEL-S-90n SIRT4 SIRT5 NMNAT2 NAMPT SIRT2 SIRT3 SIRT1 NMNAT3 SIRT6 PMC6003041__F3 Regulation of SREBP1 and lipid metabolism by oncogenic signaling in CSCs ECHS1 ACADS ACADVL COX6A2 PMC6003041__F4 Interaction between oncogenic signaling and lipid desaturation in CSCs ACLY CDC2 EGF EGFR FASN FGFR3 KRAS PMC6838739__F1 Signaling pathways in osteoclast (OC) differentiation, survival and death JUN TRADD PTH MTOR TRAF6 FADD PMC8151162__F4 Transcriptome Analysis of the Japanese Pine Sawyer Beetle, Monochamus alternatus, Infected with the Entomopathogenic Fungus Metarhizium anisopliae JEF-197 NCR1 NCR2 TBK1 CASP8 MYD88 PMC10933439__F1 Canonical Activin-, BMP-, and IFN-mediated signaling pathways BMPR2 SMAD9 ACVR2B SMAD1 ACVR2A DKFZp781O1323 STAT2 IRF9 SMAD2 SMAD4 STAT1 SMURF1 USP18 JAK1 TYK2 PMC5705900__F8 Possible mechanisms through which crocetin and AS101 reverse the early adaptive response of the ovary to CPM SIRT3 CPM PMC8674449__F2 Ecogenomics Reveals Microbial Metabolic Networks in a Psychrophilic Methanogenic Bioreactor Treating Soy Sauce Production Wastewater TRO FH NHS MAL PMC5455971__F2 Targeting iron metabolism in drug discovery and delivery ERFE STAT3 BMP6 SMAD1 TFR2 DKFZp781O1323 SMAD4 HAMP HFE IL6 HFE2 PMC3706566__F6 Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization UCP2 SIRT3 FIS1 UCP3 MFN1 MFN2 NRF1 SIRT1 PMC2851161__F1 The Notch signaling pathway NOTCH2 NOTCH3 NOTCH1 PMC7926651__F4 Main mechanisms of Kupffer cell activation during chronic ethanol exposure NLRP3 TLR4 IL1B PMC8593816__F5 Clinical Significance of Screening Differential Metabolites in Ovarian Cancer Tissue and Ascites by LC/MS CYP2R1 CNDP2 FASN FADS2 DPYD CNDP1 ACADM CYP27B1 ACSL1 ALOX5 CYP7A1 CYP11A1 DPYS PMC2492871__F4 Networks top-ranked by Ingenuity Pathway analysis after knockdown of TP53 (A) and LSR1+TP53 (B) S100A4 SPINK1 TNFAIP2 BNIP3 RRM2B PMC5833825__F6 Photosensitization of A2E triggers telomere dysfunction and accelerates retinal pigment epithelium senescence RPE CXCR4 IL1B PMC11931864__F6 Molecular mechanisms through which hUC-MSC-sec improves aged oocyte quality MSC BDNF BTG4 DAZL PMC7096478__F7 The possible mechanisms used by M APC HES1 NOTCH1 PMC5292006__F4 Ingenuity pathway analysis of uniquely hypomethylated promoters CD80 LAT JAK3 SOCS2 SOCS3 CTLA4 TNF FYN IL9R IL2 GRB2 JAK1 LCK PMC7096478__F8 The possible mechanisms used by M RUNX1 BEST2 PMC2586079__F1 COMPLEMENT ACTIVATION FRAGMENT Bb IN EARLY PREGNANCY AND SPONTANEOUS PRETERM BIRTH HEL-S-62p C2 C1S C1R PMC7096478__F9 The possible mechanisms used by M RUNX1 NOTCH1 PMC7214175__F7 Proposed model of metformin‐induced activation of the Hippo pathway in drug‐sensitive and drug‐resistant breast cancer cells FRMD6 SCRIB NF2 PMC7303083__F7 LPS-TLR4 MAPK pathway stimulated by 1% ECVE treatment of LPS-matured MoDCs HMGB1 TAB3 IRAK1 IRAK2 TRAF6 IRAK4 HEL-S-44 MYD88 PMC4836665__F3 Differences in Whole Blood Gene Expression Associated with Infection Time-Course and Extent of Fetal Mortality in a Reproductive Model of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection RAD21 FZR1 FYN SHB CDC20 APC SMC3 CSK ITK GRB2 SLK PMC4123209__F2 Tale of two cytokines: IL-17 and IL-22 in asthma and infection STAT3 IL17RC EBP TRAF5 JAK1 TRAF6 TRAF2 TYK2 PMC6720052__F7 Schematic of the signalling pathways involved in AVE 0991-attenuated pyroptosis and hepatocyte damage induced by heat stress by inhibiting the ROS-NLRP3 inflammatory signalling pathway NLRP3 IL16 NOX4 PMC8634426__F1 From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin RAD50 MRE11A H2AX ATM ARHA NET1 PMC11907527__F6 Subgroup-specific heterogeneity in common pathways CD40 ZAP70 TREM1 LTA LTBR TIRAP OSM CARD11 FACL4 IRAK1 GHRL TRAF3 TRAF6 MYD88 NGF BCL10 ALOX5 PLCG2 HDAC2 ETV5 RAB27A IFNGR1 CASP8 SERPINA1 AREG PRTN3 TNF FOS UBE2V1 ICOS MAP3K1 IL1RN NT5E TRAF5 MAP3K7 TNFSF11 LCN2 EGF HGF TGFA TNFAIP3 TNFSF8 NFKB2 TAB3 GH1 CR1 LTB4R IL1R1 BTRC CARD10 TNFRSF17 SGPP1 IL18 LDLR CHUK ELANE CD40LG MMP9 CD55 TNLG2B HDAC1 PDK4 MAP3K7IP1 IKBKB RELA BMP2 ERBB2 TRAF2 PMC8256170__F2 OX40/OX40L Axis Regulates T Follicular Helper Cell Differentiation: Implications for Autoimmune Diseases APC CXCR5 TRAF2 PMC4266467__F1 iNOS: A Potential Therapeutic Target for Malignant Glioma STAT3 EGF COX2 EGFR PMC8637192__F6 Copper Tolerance Mechanism of the Novel Marine Multi-Stress Tolerant Yeast Meyerozyma guilliermondii GXDK6 as Revealed by Integrated Omics Analysis GCLC HEL-S-64p CIT PMC4532730__F1 Intercellular apoptosis-inducing ROS signaling LPO PMC11907527__F3 Additional analysis on Amini et al, J Neuroinflammation, 2023 (PMID: 36691064) SLC39A14 PIK3R1 HIF1A PPP3CC WNT2B ZNF331 SWAP70 ADAM23 CDK6 PPM1K PTPN4 EPHX2 NUP205 ILF3 CTLA4 C1orf57 PDP2 ZC3H8 RABL3 EXOC2 POLS NBEAL1 PRKCQ TTC39C TMEM116 TRAF5 MTMR4 HGF GLS AKT3 PROCR MTOR IL11RA PRKCH EP400 GPR18 PDE3A DPP4 CLEC2D CASK RPL22 P2RY10 AGPS DDX5 BEX2 PTPN11 SYNE1 GATA3 HOXC4 CD96 S1PR1 MTHFD1 CCL28 RNF144A LRCH1 PFAS IL23A NMT2 PMC8689983__F3 Reactome pathway knowledgebase 2022 HNRNPL GABARAP HIPK2 ELAVL1 GABARAPL2 PMC2492871__F5 Networks top-ranked by Ingenuity Pathway analysis after knockdown of LSR1 (A-B) SERPINE2 PLAUR MYOCD ELF3 PMC2492871__F6 Networks top-ranked by Ingenuity Pathway analysis after knockdown of LSR2 (A-B) ADAM19 SPINK1 SERPINE2 FLNA PMC6545975__F1 Receptor signaling pathway and recruitment of IL-1RAcP IL36A IL36B MYD88 PMC8300159__F1 Crossroads between Zinc and Steroidal Implant-Induced Growth of Beef Cattle HBEGF IGF1 EGFR GPER MMP2 IGF1R MMP9 PMC6506518__F8 Proposed multi-target and multi-component action modes of hawk tea as a previously unrecognized cholesterol-lowering agent LPL NPC1L1 LDLR APOB PMC11929655__F3 Protein–Protein Interaction (PPI) Network and Enrichment Analysis TSC2 TSC1 TXNIP TP63 SFN YWHAZ YWHAG PMC4761371__F2 RhoGTPase switch at the cell–cell contact CDH2 TRIO TIAM1 VAV2 ARHA RAC1 PMC4532730__F8 High concentrations of photofrin-derived singlet oxygen triggers the generation of cell-derived singlet oxygen, catalase inactivation and intercellular ROS-dependent apoptosis signaling through the NO/peroxynitrite and HOCl signaling pathway LPO PMC4532730__F9 Catalase inactivation by low concentrations of photofrin-derived singlet oxygen requires an additional amplification step that is mediated by the FAS receptor and caspase-8A LPO PMC9008482__F2 mRNA Translation Is Dynamically Regulated to Instruct Stem Cell Fate LARP1 ELF2 MTOR EIF2A ELF3 EIF4E PMC11929655__F1 MTOR signaling pathway RHEB TSC2 TSC1 DDIT4 MTOR PMC6895189__F4 Adaptive divergence of Notch signalling pathway in tiger DTX2 DTX4 NUMB DVL2 PSEN1 NCOR2 PSENEN CTBP2 MAML3 ADAM17 PSEN2 CTBP1 JAG2 CREBBP DVL3 LFNG SNW1 MFNG DLL3 HES1 PMC7102443__F8 Pleiotropic functions of Htt in the TLR-4 signal transduction system in BMMCs SNAP23 SYK FYN TLR4 IRAK1 LYN TRAF6 IRAK4 MYD88 PMC7048264__F7 HIF-2A regulation via DDX28 RBM4 DDX28 PMC11842281__F4 PI3K‐AKT signaling pathway by nSolver Software (PathView) SYK MYB EIF4B BAD RBL2 PTEN CD19 MTOR RAC1 IRS1 RHEB TSC2 BCR MDM2 PMC8722197__F6 Endophytic fungus Pseudodidymocyrtis lobariellae KL27 promotes taxol biosynthesis and accumulation in Taxus chinensis MYB ERF PMC5923370__F3 Summary of discussed cancer-relevant pathways that activate YAP and TAZ EGF TGFA AXL EGFR BMP4 RHO SRC ARHGAP29 CTNNB1 PMC4926186__F2 Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses STAT1 STAT2 IFNAR1 EIF2A JAK1 TYK2 ELF3 PMC6860913__F3 TLR9 has been proposed to signal through two independent cascades, (A) the canonical inflammatory pathway and (B) the non-canonical stress tolerance pathway TLR9 IRF7 TRAF6 MYD88 PMC12170596__F3 Microbiota dysbiosis alters gastric epithelial cell signaling pathways CDX2 OLFM4 CGAS SP1 ATG16L1 RUVBL1 PTGER4 GPR49 CTNNB1 PMC12170596__F4 Microbiota shapes the suppressive immune microenvironment STAT3 NLRP3 TLR4 GC TLR9 IRF3 PMC5147901__F3 Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection KLF4 NCOR2 IFNG IL10 CX3CR1 MREG CX3CL1 FBXO7 HP TRAF2 CSF1R PMC7586489__F1 Locations of DNA base lesions govern TNR instability through BER OGG1 FEN1 PMC7586489__F2 TNR expansions and deletions through BER FEN1 PCNA PMC12170596__F2 Microbiota increases host cell genomic damage and suppresses genome repair MSH6 MSH2 MSH3 TLR4 MYD88 PMC3552307__F1 Double-stranded and single-stranded RNA signaling pathway TLR3 TLR9 IRF3 IRF7 TLR7 TRAF3 TRAF6 TRAF2 FADD MYD88 PMC3349304__F6 Identification of transcripts and proteins associated with hemocytes TRAF4 HEL-S-62p VTN TRAF6 REL CD63 MYD88 PMC6600448__F2 Molecular mechanisms of alcohol-induced apoptosis and autophagy in hepatocytes STAT3 BTK FAS CYP2E1 GSK3B CCND1 CTNNB1 FADD PMC11674514__F3 Various IL6 pathway inhibitions SOCS1 SOCS3 IL6 IL6R PMC8033034__F1 Unfolded protein response (UPR) signaling pathway ATF4 EIF2A XBP1 PMC8033034__F2 Relevant events involving IRE1A and PERK proteins at mitochondria–ER contacts (MERCs) MFN2 ATF4 MTOR PMC11839352__F4 枸杞多糖改善高原低氧环境雌性大鼠生殖损伤的机制研究 STAT3 HPSE ADRA1D TLR9 PIN1 HDAC3 EGLN1 BCL2L1 HTR1B DRD2 ADRA2A PRKCA MMP2 HEL-S-11 KDR ABCB1 NR1i1 CES1 ABCB11 HK2 TRPV1 VEGFA SLC22A6 DTYMK HMGCR ECE1 HSD11B2 FDFT1 EGFR NR1C2 AKR1B1 DRD3 PRKCH OPRK1 IGF2R PRKCE NR3A2 TLR4 IL2 SLC1A1 CDC2 FOLH1 NEU3 CHRNA7 PTPN1 ATP1A1 FABP4 OPRM1 FGF2 NR1C1 FBP1 LGALS4 CASP3 KDM5C PTPRB SLC1A2 CA9 CPT1A ADA PMC5562963__F1 Early and lethal neurodegeneration with myasthenic and myopathic features GMPPB DPM2 RFT1 DPAGT1 DPM3 ALG5 MPDU1 DOLK ALG6 ALG10 DOLPP1 ALG13 DPM1 ALG1 PMC11674514__F1 IL6 classical and trans-signaling activation pathways ADAM17 ADAM10 IL6 PMC5779028__F8 Local TRPV4 channel‐dependent Ca2+signaling regulates endothelium‐dependent vasodilation in resistance‐sized PAs CSA2 MALL GC PMC8946148__F2 Emerging Roles for Mammalian Target of Rapamycin (mTOR) Complexes in Bladder Cancer Progression and Therapy RHEB MLST8 TSC2 RICTOR TSC1 EGFR PTEN DEPTOR PMC7794044__F4 Signalling pathways activated by peptidoglycan upon stimulation of NOD-like receptors NLRP1 NLRP12 RIPK2 ATG16L1 NLRP3 NOD2 IRF7 TRAF6 IL1B CARD9 PMC8206194__F2 Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints LRP5 LRP6 CTNNB1 PMC5993794__F3 Ingenuity Pathway Analysis of SNX8, PCP2, KNG1, and RORA SNX33 SNX9 SNX8 RORA PMC4383744__F1 Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape CD59 FH HEL-S-62p CD55 PMC4383744__F2 Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape HEL-S-62p C2 C1S C9 CR2 CR1 CP PMC8704836__F6 Lowering pO2 Interacts with Photoperiod to Alter Physiological Performance of the Coastal Diatom Thalassiosira pseudonana SDHB CYB COX10 COX2 PMC11667232__F6 Big data analytics for aortic aneurysm SPN POR MYLK TIMP3 MMP12 COA1 SKI PMC9348623__F6 Molecular Mechanisms of the Convergent Adaptation of Bathypelagic and Abyssopelagic Fishes GRK1 RHO SRC PMC8623813__F1 Clinical Translation of Combined MAPK and Autophagy Inhibition in RAS Mutant Cancer JUN MYC FOS PMC7855863__F3 Key Metabolic Functions of Beta-Arrestins: Studies with Novel Mouse Models RXRA AgRP IRS1 PMC3782237__F4 Mammalian target of rapamycin pathway is deregulated by mutations in cancer EGF TSC2 TSC1 PTEN MTOR PMC3204462__F1 TRAIL signaling pathway and regulatory proteins BAX CASP9 MOAP1 BAD ARAP1 MCL1 DAP3 ARC TRAF2 FADD PMC7149927__F9 Schematic diagram showing the effect of MG-infection on chicken thymus tissues NLRP3 MTOR TRAF6 IL1B MYD88 PMC6736567__F1 Canonical Hh signaling ADRBK1 ITCH CCND2 SUFU PC SMO PMC12057268__F1 Interactions between chronic inflammatory pathways, MetS, and various skin diseases EGF BTNL2 BACH2 IGF1 IL3 TLR4 EGFR IL4 IL2RA SH2B3 VCAM1 PMC11624276__F8 Schematic diagram displaying the role and mechanism of GPR160 in bone cancer pain MME SP1 GPR160 PMC5141645__F1 Schematic diagram of HGF/c-MET signal transduction pathway STAT3 HGF MTOR PMC5125891__F3 Sphingolipids in Mitochondria BAX FAS TRADD TNF FADD PMC7012211__F6 Schematic diagram displaying the impact of AREG on intrinsic apoptosis signaling BAX BAD EGFR AREG PMC5584463__F1 Mechanistic target of rapamycin (mTOR): A mediator of social development HP MTOR PMC7586489__F4 Crosstalk between BER and MMR promotes TNR expansions and suppresses TNR deletions OGG1 FEN1 TNR PMC2721971__F3 EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis† EGF CBL EGFR ARF6 GRB2 PMC8348732__F4 Post-Translational Acetylation and Deacetylation of Signaling Proteins and Transcription Factors after Cerebral Ischemia: Facts and Hypotheses HDAC3 MAX GSK3B MDM2 SIRT2 SIRT1 HDAC6 PMC9386470__F1 BTK, the new kid on the (oncology) block? SYK BTK BCL10 BCR CD19 LYN MYC MYD88 PMC9061815__F5 scATAC-seq analysis and heterogeneity of regulation between MGE and LGE ST8SIA4 JUND ZIC4 SMC3 PBX1 TCF4 DLX1 ISL1 ASCL1 ID4 MAF NRF1 SOX4 TMSB10 HES5 SOX11 OLIG2 ZNF219 NRXN3 NR2F1 SST NKX2-1 DLX2 POU3F2 POU3F3 TSHZ2 NR3B3 TMEM123 MAX ZNF704 ZNF503 ZNF107 RHBG CREB5 ZFHX4 MEF2C FOXM1 ACTG1 JUN IGF2BP3 SOX2 BCL11A LHX6 ARX MEF2D LHX8 NR2F2 RHOB NFIB DLX5 PMC11939868__F2 Long non-coding RNAs (lncRNAs) regulate immune escape in the tumor immune microenvironment (TME) STAT3 PMC11939868__F3 LncRNA and Tils in TNBC MYL2 MICA MICB PMC7898723__F3 Whole‐exome sequencing of non‐BRCA1/BRCA2 mutation carrier cases at high‐risk for hereditary breast/ovarian cancer MSH6 RFC1 RAD50 MSH2 FEN1 NEIL1 FAN1 FANCA ESCO2 FANCE MUTYH CHEK2 UNG ATM TDG PMC2826517__F1 The current understanding of PELP1 signaling pathway STAT3 PELP1 EGF EGFR SRC PMC6387057__F1 Schematic depiction of the mTOR signaling network RHEB CAD TFEB MTOR SKI DEPTOR PMC5860940__F2 Simplified overview of the intracellular signaling mechanisms governing CCA cell motility and invasiveness BMI1 S100A4 FBXW7 SALL4 SOX9 GSK3B PTEN MTOR PMC8615881__F1 Matrix Metalloproteinases in Endometriosis: A Potential Target MMP7 STAT3 MMP10 IL34 EGFR IL37 JAK3 MMP9 HEL-S-94n COX2 MMP2 MMP3 FGA PMC8279385__F2 Specialized pro-resolving lipid mediators in pulmonary inflammation diseases: mechanisms and development IL25 IL13 IL33 PMC7202522__F5 USP22-pivot gene-module-pathway network suggesting USP22 could affect multiple pathways by up-regulating UBC SCARB2 SOCS1 UBE2J2 UBE2J1 CDC20 UBE2C UBE2L6 AP4M1 AP1S1 CDC6 UBE2W CREM MYC FBXO2 UBA2 CDC2 MCOLN1 UBC APC RNASEL MED1 SORT1 USP22 CDK2 UBE2A CDC25B PMC6458165__F1 Networks related to immune modulation and inflammatory response NFKBID OSM TNFRSF10B AMPD2 PTPRE PTEN ADD2 CD133 DUSP2 ACR PMC6458165__F2 Ingenuity pathway analysis networks related to neurological disease are presented in this figure (A,B) POR ZNF331 AIP HEL110 PMC2587085__F1 Targeting EGFR and Src Pathways in Head and Neck Cancer ERBB3 ERBB4 EGFR ERBB2 SRC PMC5941822__F1 Insulin signaling pathway RHEB TSC2 ASL TSC1 GSK3B PTEN MYC PMC3152870__F4 Signalling pathway of type III interferons (IFNs) compared with type II and type I IFNs IFNG STAT1 IFNGR2 IFNGR1 IRF9 PMC5154826__F2 Hedgehog Signaling in the Stomach IFNG MSC SHH IL1B PMC2905627__F7 Schematic diagram demonstrates intracellular signaling events in the Ras/ERK1/2 pathway as well as the upstream and downstream cascades activated by GDNF in the C18-4 cells GDNF CDK2 ATF1 GRB2 RET PMC7341381__F1 Structure of the Slit/Robo protein ROBO2 ROBO3 ROBO1 CTNNB1 PMC4475536__F3 Mechanism of action of paclitaxel BAD TLR4 MYD88 PMC3172101__F1 New additions to the Hippo pathway in flies (a) and man (b) CD44 WBP2 AMOT PMC5447946__F5 ENOs and 14-3-3 in neurodegeneration BAD NLRP3 LRRK2 GSK3B PLG SNCA PMC3845023__F1 Sulfate assimilation pathway PAPSS1 PAPSS2 SLC35B2 SLC35B1 HEL20 PMC6425613__F6 Functional enrichment and gene network analysis ADAR CD59 OSM C3AR1 HEL-S-62p TNFRSF1A HLA-DRB1 C1R IFI30 IL33 SOCS2 IL2RA C1QB PELI3 TRIM68 CR1 IL1R1 HLA-DRA HLA-E IFITM3 CXCR6 IL18R1 FITM2 FRS2 CFD C1S HLA-DQA1 IFITM1 CFH IL7R IRF8 PRTN3 FGF10 HLA-DQB1 ARAF CCL13 CNTF CCL19 C1QA CFP TNFRSF11B IL13RA2 PMC12179084__F2 Key signalling pathways implicated in macrocephalic ASD RHEB TSC2 TSC1 NF1 CHD8 PTEN MTOR CTNNB1 PMC3497822__F7 The signaling pathway by which FSH promotes AKT activation in GCs GC GAB2 IRS1 PMC11662456__F1 Figure demonstrates PPARG and its relation to signaling pathways H1-1 H1-2 PMC5187887__F1 Schematic diagram representing chromosomal DNA and the major components of the DDR signaling pathway (top) RAD52 ATR BRCA1 H2AX BRCA2 CDK2 BCL2 ATM PMC5117143__F7 ATR is required to maintain G2/M checkpoint integrity and prevent apoptosis induced by proliferation-associated DNA damage BAX ATR HEL-S-62p ATM PMC7181472__F5 Kunxian capsule in treating RA STAT3 MTOR TRAF6 TNF RORA PMC7181472__F6 Mechanism of side effect caused by Tripterygium hypoglaucum hutch and the mechanism of alleviation compensated by the rest of herbs NOS2 REST IMPDH2 ASNS PMC10253306__F2 Interactions found in polyQ-containing ID hub proteins located in both cytoplasm and nucleus using protein interaction annotation of HPRD HDAC3 ATXN1 PMC10253306__F3 Splicing Modulators Are Involved in Human Polyglutamine Diversification via Protein Complexes Shuttling between Nucleus and Cytoplasm CDC42 HAP1 RHO GRB2 VCP HDAC6 PMC8316605__F1 Cryo-EM: A new dawn in thyroid biology TG TSHR PMC8316605__F2 Cryo-EM: A new dawn in thyroid biology TH TG DIO1 TSHR HEL111 TPO PMC8105667__F5 Transcriptome analysis identifies signaling pathways related to meat quality in broiler chickens – the extracellular matrix (ECM) receptor interaction signaling pathway CD44 VWF CD36 CHAD CD47 PMC8599584__F6 KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway CDC42 KIF15 EGF EGFR PMC9179967__F4 Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling PTCH1 SHH SMO CCNB1 GLI3 PMC8054134__F2 Sources of proline in RPE SLC6A20 PYCR2 PMC2891965__F8 Updates in the characterization of the COX-2 pathways in human neutrophils LTA COX2 PMC8054134__F4 Proline generates GSH and NADPH to counter oxidative stress ME3 ME1 PRODH HEL-S-26 PMC7113187__F8 Proposed mechanism of BMP6 signaling pathway regulated by PSMD14-ALK2 axis in colorectal cancers BMP6 SMAD1 SMURF1 DKFZp781O1323 SMAD4 PMC10861954__F4 Apoptosis and Inflammatory Signal Pathways Associated with Unremitted ER Stress and UPR ATF4 EIF2A TRAF2 PMC5072394__F1 Viral evasion of intracellular DNA and RNA sensing MAVS TRIM25 HEL-S-69p IRF3 IRF7 PMC3026989__F1 The innate immune induction pathway through RLR activation IRF3 IRF7 IFNB1 PMC8082775__F3 Nonsense-mediated RNA decay and its bipolar function in cancer SLC7A11 ATF4 EIF2A MAP3K14 UPF3A PMC3497822__F1 The signaling pathway by which FSH promotes AKT activation in GCs GC GAB2 IRS1 PMC4008642__F1 Molecular Pathways: BRAF Induces Bioenergetic Adaptation by Attenuating Oxidative Phosphorylation EGF EGFR AIP BRAF PTEN MTOR PMC4021393__F2 Activation of the "Role of BRCA1 in DNA Damage Response’ pathways in NCR versus CR samples BARD1 IFNG ATR BACH1 ATRIP MSH2 MRE11A ATM ATF1 MDC1 PMC10861954__F3 Unfolded Protein Response ATF4 EIF2A PMC7944059__F7 Kyoto Encyclopedia of Genes and Genomes pathway map illustrating differentially expressed genes (DEGs), as identified by protein-protein interaction network analysis using STRING TESC TRO KIT NTM GHR PMC3109408__F2 Simplified diagram of Kynurenine pathway: during neuroinflammation, 95% of the dietary tryptophan is metabolized along the KP within the brain HEL-S-90n KMO PMC12094478__F3 Mechanism of EVs in AKI SIRT3 KEAP1 CD5L PMC8358851__F1 Drivers of phenotypic variation in cartilage: Circadian clock genes NPAS2 DBP DAP PMC3411757__F1 Modular Nature of Dendritic Cell Responses to Commensal and Pathogenic Fungi SYK CD80 RAF1 RELB RNASEL RHO RAC1 CD83 STAT1 BCL10 MHC2TA TLR3 PLCG2 COX2 IL16 LYN ISG15 SRC OAS1 CCL20 CARD9 CCL17 PMC6747549__F1 Schematic summary of the molecular pathways of F TIGIT IL1B CTNNB1 MYD88 PMC9520027__F11 Identification of lysophosphatidic acid in serum as a factor that promotes epithelial apical junctional complex organization LPA NECTIN2 KPG_010 RHO LPAR1 CTNNB1 PMC6487480__F1 Polyamine metabolism and cancer: treatments, challenges and opportunities APRT MTAP SMOX PAOX ARG1 PMC4326377__F10 Activation of BV2 microglia could trigger a strong inflammatory reaction in PC12 cell apoptosis by toll-like receptor signaling pathway BAX TLR4 MYD88 PMC395917__F5 BMP4 and LIF signaling in pluripotency STAT3 SMAD1 MAP3K7IP1 BMP4 LIF SMAD4 PMC9549772__F2 Chinese Herbal Medicines for Diabetic Nephropathy Fibrosis Treatment NOTCH2 CTNNB1 PMC7348083__F2 Heat shock protein 90 inhibition and multi‐target approach to maximize cardioprotection in ischaemic injury KEAP1 HSF1 CDC37 PMC11884866__F10 Diagram illustrates the role of PCBP2 in immune evasion in prostate cancer TBK1 IRF3 PMC3770300__F1 Computational framework of 3D vascularized bone regeneration within a porous biodegradable CaP scaffold BMP2 MSC RUNX2 PMC1895551__F1 Prosurvival signaling pathways and their downstream targets BAD CASP3 GRB2 PMC8674840__F5 ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses STAT1 MAVS STAT2 IFNAR2 IFNAR1 IRF3 JAK1 TYK2 PMC5607427__F6 Model of Syk and SFK signaling in B CDC42 SYK MARCO RAC1 PMC3338536__F4 TDP-43 Identified from a Genome Wide RNAi Screen for SOD1 Regulators SF3B2 TARDBP PSMD11 UBC HEL70 HMGN1 PRIM1 CRYBA4 HEL-S-92n KEL KLRG1 POLD2 SGTA PMC3291304__F1 Protein quality control systems are potential targets for mechanism-based treatments of demyelinating Charcot-Marie-Tooth disease (CMT) USP14 MPZ PMP22 PMC4714209__F1 Biosynthesis of Sec on its tRNA SEPSECS PSTK PMC8822596__F2 Ferroptosis in cancer and cancer immunotherapy TF RAB7A STEAP3 GPX4 TPD52 GCLC ATG5 HEL-S-64p DHODH PMC8822596__F3 Ferroptosis in cancer and cancer immunotherapy HCAR1 TFRC KEAP1 GPX4 LPCAT3 FACL4 PTEN SLC7A11 NF2 HEL-S-64p NOX4 HEL-S-44 PMC8803838__F2 Neutrophils in chronic inflammatory diseases ICAM2 IF2B1 NLRP3 CXCL1 CD177 IL18 CXCL2 CTSG IL1B MPO PMC8113860__F3 Crosstalk and regulation of innate immune cells in the esophageal cancer tumor microenvironment CXCL9 STAT3 HMGB1 CXCL16 SIRPA CXCL2 CXCL10 CCL2 CCL20 CD47 CXCL3 PMC5385394__F1 Major pathways associated with pancreatic ductal adenocarcinoma and site of action of current treatments EGFR SMAD4 MTOR PMC4123742__F3 Current model for replication-independent ICL repair ERCC1 XPA REV1 POLK POLN XPC PMC6749452__F8 The metabolic pathway networks of particularly significant potential biomarkers for the therapeutic effect of p-b4 on MSU crystal-induced GA rats ALOX5 LTC4S KDSR PMC8333862__F1 NAD+ Homeostasis in Diabetic Kidney Disease NAPRT HEL-S-90n NAMPT PMC8500707__F1 Genomic Landscape of HIV-Associated Plasmablastic Lymphoma CD44 MYC NOTCH1 PMC9697247__F1 Selective Activation of the Wnt-Signaling Pathway as a Novel Therapy for the Treatment of Diabetic Retinopathy and Other Retinal Vascular Diseases RECK APC TSPAN12 GSK3B LRP5 CTNNB1 PMC2720065__F8 Proposed signaling pathway of mmLDL-induced, TLR4/Syk-dependent ROS generation and proinflammatory cytokine expression SYK TLR4 CD14 MYD88 PMC7974260__F2 Representative diagram of circRNAs that interact with the circRNA-miRNA-mRNA regulatory network/RBPs and regulate oncogene or tumor suppressor signaling pathways ZNF609 MYLK VEGFC HEL-S-133P SMAD4 PTEN SLC8A1 VEGFA FNTA PMC3161675__F3 Signal Transduction Involving the Dmp1 Transcription Factor and its Alteration in Human Cancer BMI1 TBX2 DMP1 JUNB TBX3 MDM2 MYC CCND1 CDK4 PMC10511911__F5 Regulation of insecticide resistance mechanisms involves epi-transcriptome signals, detoxification signaling pathways, and long non-coding RNAs (lncRNAs) TF KEAP1 AHR PMC8295591__F2 HIV-1 Hijacking of Host ATPases and GTPases That Control Protein Trafficking ABCE1 RAB27A RAB7A RAB11A RANBP1 PMC6976902__F1 miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo SMO PMC5274667__F6 Cross talk between lipid/glucidic metabolism and cancer LPL ANGPTL4 ANGPTL3 IGF1 PMC5274667__F3 Molecular mechanism governing ANGPTL4-mediated TG hydrolysis TG ANGPTL4 GPIHBP1 PMC8850798__F8 Selenium binding protein 1 inhibits tumor angiogenesis in colorectal cancers by blocking the Delta-like ligand 4/Notch1 signaling pathway HEL-S-134P DLL4 HES1 NOTCH1 PMC2959101__F4 Schematic diagram of NELL-1 signaling pathways in osteoblast cells NELL1 SMAD1 BMP2 SMAD6 SMAD4 RUNX2 PMC4123742__F7 Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair ERCC1 ATR RAD50 RAD51 FANCM FAN1 FANCL IL1A BLM FANCB FANCD2 MRE11A BRCA1 RNF8 FAAP24 SLX4 EME1 PMC6555892__F1 MINA Workflow CXCL9 IL18R1 IL12A EGFR IFIH1 IL2RA IL10RA IL-21 PTPN22 DGKA ATG12 IL2 SH2B3 STAT4 GRB2 PMC6200076__F1 Mechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma SGK1 BRAF MTOR PMC8263687__F8 Novel mechanism driving poor-prognostic gastric cancer: overexpression of the transcription factor Krüppel-like factor 16 promotes growth and metastasis of gastric cancer through regulating the Notch pathway CDH2 MFAP5 KLF16 CDK2 CTNNB1 PMC5795269__F1 Nicotinamide adenine dinucleotide biosynthetic pathway SARM1 HEL-S-5 NAMPT PMC6896717__F8 The schematic model of the process of regulating Akt/mTOR signaling by NL3 RHEB TSC2 TSC1 PTEN PMC7555474__F5 Rap1 promotes tumor progression via disruption of E-cadherin-mediated cell adhesion CDH2 RAP1GAP PMC9687982__F1 Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury NLRC4 NLRP1 AIM2 PMC8514845__F2 Scaling the tips of the ALPS STAT3 SOCS3 PMC10525645__F1 Abnormalities in Copper Status Associated with an Elevated Risk of Parkinson’s Phenotype Development ATOX1 CCS SLC25A3 ATP7B COMMD1 COX17 HEL-S-44 ATP7A CP PMC5747363__F2 Molecular targets of and mechanisms of resistance to major antimalarial drugs CYB DHFR DHODH DHPS PMC4506514__F1 Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma RB1 PIK3CA CDKN2A FRS2 SOS1 NF1 FGFR4 ATM PTEN MDM2 GRB2 CDK4 PMC7339444__F8 Pcdh8 in Wnt/PCP signaling in Xenopus PCDH8 ARHA RAC1 DAAM1 PMC10525645__F2 Simplified scheme for the conversion of food-derived copper into biovaluable copper ALB ATOX1 ATP7B COX17 HEL-S-44 ATP7A CP PMC6539971__F1 Microtubule-associated protein 1 light chain 3 (LC3)-P62 autophagy signaling pathway ATG3 ATG12 ATG5 PMC11395544__F9 Oral Administration of Probiotic Bifidobacterium breve Ameliorates Tonic–Clonic Seizure in a Pentylenetetrazole-Induced Kindling Mouse Model via Integrin-Linked Kinase Signaling CASP3 HEL-S-28 CTNNB1 PMC12146023__F2 Casein kinase 1 epsilon (CK1E) as a potential therapeutic target in chronic liver disease TBK1 EGFR APC FASN GSK3B LRP5 LRP6 TRAF3 CTNNB1 GLI3 PMC8443620__F2 Metabolic capabilities in three new actinobacterial classes TH MAL PMC3721281__F2 Asparagine-linked glycosylation pathway ALG5 ALG6 RFT1 ALG10 DPM1 ALG13 ALG1 ALG3 PMC3219404__F1 Putative involvement of the receptor for advanced glycation endproducts (RAGE) during infection HMGB1 VCAM1 S100A12 PMC4087161__F2 Phosphorylation of Foxo1 at S253 by Akt promotes Foxo1 cytoplasmic retention and ubiquitination, which serves as a central mechanism controlling Foxo1 stability and activity () PRMT1 DYRK1A SIRT2 PMC12057185__F2 Processes of the three major classes for protein lipidation HRAS ICMT NRAS RHO RCE1 PMC9503909__F8 Fractionated Proton Irradiation Does Not Impair Hippocampal-Dependent Short-Term or Spatial Memory in Female Mice H3F3B MACROH2A1 MTX2 H2AX H2AJ MYADM ATP6V0C ATP6V0D1 COX6B1 PMC9629566__F3 Niloticin binds to MD-2 to promote anti-inflammatory pathway activation in macrophage cells IL19 TLR4 MYD88 PMC12057185__F7 Cohesive model of lipidation in the TME HGF BCR HEL-S-133P TLR4 IRF3 MICA LYN MICB TNF RAC1 PMC12057185__F5 S-palmitoylation within the TME GSDMD ZDHHC7 HEL-S-133P ZDHHC19 ZDHHC18 ZDHHC9 ZDHHC5 MTOR ZDHHC13 ZDHHC3 PMC12057185__F6 S-prenylation within the TME RHEB SYK CLEC9A EGFR AMOT ROCK1 CRACR2A ARHA RHO GRB2 DEPTOR RAC1 PMC12057185__F3 Comprehensive kinetic model illustrates dual lipidation interplay within the TME signaling pathways TRIM31 FYN MAVS LAT APC LCK PMC12057185__F4 N-myristoylation in the TME STAT3 BAD CGAS FAS ARF1 IRF3 MTOR FGF10 ACSL1 BTK BCR LAMTOR1 SRC PMC6429383__F7 Compound-target network of 3DC2ME FLT3 PPARG CYCS CTSS PLK1 FGFR2 POR MAPK14 ALB GNAS CHRM4 MME CACNA1G DRD4 F10 PRKCA PTGS1 POMC SMO KDR SRC ABCB1 CACNA1A NOS2 CES1 METAP2 CTSK TRPV1 VEGFA ITGB3 RPL3 ACACB GABRA2 RXRA ADRB2 EDNRB CYP2C9 BCL2 MAPK10 NR3B3 SLC12A1 TH EGF NFKB2 DHFR LYZ NR1C2 PTGDR2 PDE4B FABP6 RORA PRKCB RARA NR1B3 CHRNA2 REN TUBB1 SHBG RARB NR3A2 APP CACNA2D3 CACNB3 CACNG1 CACNA1S GABRP ADGRD1 CACNB1 HRH1 KIT TACR3 PTGS2 FECH HBA2 NR1C1 GNRHR NFKBIA CFTR CACNB4 PRSS1 LCK PMC4672393__F1 Complement System and Antibody Mediated Transplant Rejection FH C4A C4B_2 CR1 PMC4109688__F2 Toward T Cell Protein–Protein Interaction Activity Relevant to Alopecia Areata ZAP70 LAT LCK PMC8113373__F4 CircRNAs: role in human diseases and potential use as biomarkers LATS1 MKI67 AURKA LATS2 PMC5496785__F1 Restore the brake on tumor progression PTCH1 SHH SMO GLI3 PMC4985808__F7 Transcriptomic analysis of heteromorphic stamens in Cassia biscapsularis L TH CBL PMC7546716__F1 T-cell polarisation in COVID-19IL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs CXCL9 STAT3 TH CXCR3 CCR2 IL33 CXCL10 CCL2 GATA3 MYD88 IFNG RORC NLRP3 IL16 IL2 FOXP3 CCL8 PMC8113373__F2 CircRNAs: role in human diseases and potential use as biomarkers ITCH APC GSK3B DVL2 MYC CCND1 CTNNB1 PMC9709075__F6 Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus CAST IFITM2 IFITM1 PNPT1 IFNB1 OAS3 IFNA2 OAS2 PMC7893118__F1 TGFB signaling SMAD2 SMAD6 SMAD4 GRB2 PMC7602704__F1 Involvement of TPMT on the thiopurine metabolic pathway AOX1 IMPDH1 XDH TPMT PMC6170637__F4 Animal and plant cells NLRC4 NLRP3 RPS2 NOD2 NOD1 PMC8640216__F1 Interplay of the Unfolded Protein Response in Neurodegenerative Diseases: A Therapeutic Role of Curcumin ATF4 EIF2A PMC6170637__F3 Animal and plant cells TH RAN TLR4 MAL PMC9343597__F1 Present and Future: Crosstalks Between Polycystic Ovary Syndrome and Gut Metabolites Relating to Gut Microbiota PYY SHBG PMC7002574__F4A Pathway and network analysis of more than 2500 whole cancer genomes RBMX GAP43 KEAP1 PIK3R1 SMAD4 MYC ALB RB1 RPL5 CDKN2A FBXW7 SOX9 NF1 PBRM1 NRAS SOX4 NOTCH1 HEL-S-44 ARHGAP35 CASP8 MYH10 DTL MIB1 APC NTRK2 B2M RELN HEL-S-66p CDKN1A SUFU PTCH1 CALM1 HLA-A HNF1A VEGFC STK11 VAMP2 TERT CNOT2 COL3A1 TGFBR2 PLCG1 CDK12 SPOP EIF4A2 RPL22 FOXA1 CBX3 PTPRK ARHA KRAS RAC1 VHL MEN1 CREBBP KDM5C DDX3X PS1TP5BP1 EPHA2 PTPRC HNRPR BCL9 PYGL NFE2 ARID2 PRKAR1A CNBP SMARCA4 ACVR2A ID2 PLAUR TLE4 NCKAP1 NOTCH2 BHLHB2 NR2F1 HRAS CBFB BTG2 STAG2 KLF4 SF3B1 BRD7 EGFR BRCA2 BRAF PTEN CTNNB1 FST MLL2 ATM TBL1XR1 SRSF9 HOXB5 BAX KMT2C ZFP36L2 CITED2 PCF11 HNRPA3 PCDH9 SOX2 GATA3 RNF43 HOXA10 NFE2L2 SRSF4 AJUBA TNFRSF11B RRAS2 PMC8996410__F3 Proteolysis-targeting chimeras (PROTACs) in cancer therapy BRD4 CDK6 BRD7 BRD3 EGFR WEE1 CDK2 BRD2 CDK4 PMC12146603__F3 Neurotransmitter pathway affected by genetic 5‐HTT inactivation at PND8 GRM4 GLS GAD2 GRIA4 PMC6606846__F2 Regulation of (p)ppGpp metabolism in Gamma-proteobacteria HPR RELA PMC11313179__F7 Illustration of the most significant regulated target genes related to PPAR signaling pathway LPL NR1C1 PLIN5 PMC9168430__F3 Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence TPH1 IDO1 AHR PMC4568143__F1 From bench to bedside: what do we know about Hormone Receptor-positive and Human Epidermal Growth Factor Receptor 2-positive breast cancer? TGFA EGFR HRG PMC4150834__F2 MC1R, the cAMP pathway and the response to solar UV: Extending the horizon beyond pigmentation ADRBK1 MC1R ARRB2 NRAS PMC5809511__F4 Non-canonical Wnt signaling at the primary cilium MKS1 INVS FZD3 ARHA PMC8238251__F1 Endogenous AGE formation and pathobiological actions of RAGE receptor ligands HMGB1 PC JAK1 PMC8111493__F1 Regulatory T cells in ischemic stroke STAT3 CCR5 EGFR CCR6 CCL5 AREG MMP9 CCL20 CCR8 CCL1 PMC6398892__F2 Regulation mechanism of ECM/integrin/EphA1‐mediated cell adhesion HEL-S-28 ARHA EPHA1 PMC5714692__F2 Nutrient regulation of pancreatic Beta-cell proliferation TG CD36 PMC5845716__F1 TANK-binding kinase 1 (TBK1) in humoral responses ICOS TBK1 CGAS MAVS TLR3 TLR4 GC IRF3 OPTN PMC11809008__F9 HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway GSDMD NLRP3 PMC6064949__F10 A model depicting the mode that hypoxia exacerbats acute lung injury (ALI) via the toll-like receptor 4 (TLR4) signaling pathway and the protective effect of hypoxia-inducible factor 1 alpha (HIF-1A) TLR4 IL18 CD14 IL6 LBP IL1B PMC1216340__F10 Schematic model depicting potential mechanism that might contribute to epithelial-specific regulation of the CFTR gene EBP CFTR YY1 PMC5435082__F1 Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes GLA FADS2 FADS1 PMC64811__F2 Failure of endogenous regulation of wound-healing in idiopathic pulmonary fibrosis (IPF) COX2 PMC5903677__F3 Therapeutic targets for brain injury for nanoparticle mediated drug delivery NPS EPO BDNF PMC3267701__F1 Amyloid precursor protein (APP) processing pathway EGFR HEL111 PMC8802892__F5 Transcriptomic and Metabolomic Analyses Reveal Inhibition of Hepatic Adipogenesis and Fat Catabolism in Yak for Adaptation to Forage Shortage During Cold Season LPL TG IGF1 SCD LDLR FABP4 PMC12090542__F1 Five signalling pathways in regulating the immune microenvironment of DW TF SMAD2 APC LRP5 SMAD4 LRP6 MTOR SRC LEF1 CTNNB1 PMC2963177__F2 Integration of non-SMAD and SMAD signaling in TGFB1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells EGFR SMAD2 SMAD4 ARHA PMC8949198__F1 Oxidative Stress in Arterial Hypertension (HTN): The Nuclear Factor Erythroid Factor 2-Related Factor 2 (Nrf2) Pathway, Implications and Future Perspectives KEAP1 MAF FN3K PMC7021762__F7 Components of GFI on KEGG gene networks PIK3CA TNFRSF10C EGFR NFKB2 BRAF PIK3R1 PTEN MTOR EFNA1 KRAS FGF7 GADD45B NRAS EP300 PMC5122403__F8 Increased translocation of antigens to endosomes and TLR4 mediated endosomal recruitment of TAP contribute to nicotine augmented cross-presentation TLR4 MTOR IRAK4 MYD88 PMC9166893__F8 Essential role of CK2A for the interaction and stability of replication fork factors during DNA synthesis and activation of the S-phase checkpoint ATR MCM7 ATRIP H2AX CDC45 MCM3 CLSPN CDK2 MCM5 MCM6 MCM2 PMC5777733__F12 Targeting the SUMO pathway as a novel treatment for anaplastic thyroid cancer TF PIAS1 SAE1 PIAS2 PMC9445673__F8 Gene network downstream plant stress response modulated by peroxisomal H2O2 CALML3 HSF4 IRAK3 CRYAA HSPBP1 PMC5204325__F1 Cross talk between the transforming growth factor B (TGFB) family and Wnt signaling at multiple points SMURF1 APC SMAD4 SMURF2 CTNNB1 PMC8108031__F1 Repurposing metformin for the treatment of gastrointestinal cancer IGF1 IGF1R MTOR PMC6430635__F4 Different subcellular sources of MHC-I molecules for cross-presentation CD74 RAB11A SCAMP3 PMC6430635__F5 Convergence of three vesicular pathways of endocytic traffic on the cross-presentation compartment in dendritic cells SNAP23 SEC22B RAB27A RAB11A RAC1 MYD88 PMC3757665__F2 Nrf2-Keap1 signaling pathway HMOX1 PMC5509726__F3 Protein-protein interaction networks of metabolism related pathway enriched genes PPARG FUT8 FUT5 FADS2 ETHE1 ST3GAL1 ACSS2 PIG59 B3GALT5 PKLR ST3GAL6 HK2 PERP APC HEL-S-28 LDHB B3GALT2 HEL-S-30 B3GNT3 PCK2 SIAT4C FBP2 ADH6 PGM2 FABP2 DBI FBP1 B3GNT7 B4GALT2 HEL-S-87p CA9 CPT1A B4GALT4 PMC6910162__F1 Overview of metabolic pathways in atherosclerosis and trained immunity ABCG1 FAS CD36 HK2 PMC8830041__F7 Interleukin-17A pretreatment attenuates the anti-hepatitis B virus efficacy of interferon-alpha by reducing activation of the interferon-stimulated gene factor 3 transcriptional complex in hepatitis B virus-expressing HepG2 cells ISG20 SOCS1 IL17RC IL17RA IFNAR2 USP18 SOCS3 ISG15 TRAF6 TYK2 PMC5509726__F6 Protein-protein interaction networks of lipid metabolism related pathway enriched genes CD36 PLA2G2D PLA2G4F GPD1L ABCA1 PLA2G12B PLA2G2A PLA2G10 GPAM DGKA MTTP ALOX15 DGKE PLD3 PMC2801624__F1 A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches MYF5 NOTCH3 PAX7 PMC8790554__F2 Celiac disease: From genetics to epigenetics TF UNG TUG1 PMC9113239__F6 Fabrication and evaluation of a BMP-2/dexamethasone co-loaded gelatin sponge scaffold for rapid bone regeneration SMAD1 DKFZp781O1323 BMP2 RUNX2 ID1 PMC8117216__F1 Repositioning of Antiparasitic Drugs for Tumor Treatment CD44 BAX CD24 PAK1 SOX2 MTOR MAST1 PMC8113030__F3 Redox regulation of the insulin signalling pathway PTEN PMC3646677__F1 B-Raf protein and signaling pathways FLT3 MAP4 EGFR BRAF CR2 MAP2 GRB2 MTOR CR1 PMC8113030__F4 Redox regulation of the insulin signalling pathway GSK3B PMC5958133__F6 Gene transcription in key nutrient metabolic pathways involved in lipid synthesis between L FAS DLAT SCD HEL-S-162eP PMC8113030__F5 Redox regulation of the insulin signalling pathway SGK1 AKT3 IGFBP1 IGFBP4 IGFBP2 PTEN IGF1R INS IGF2 IGFBP6 IRS1 IGF1 IGFBP5 PMC9389448__F2 Modes of action and diagnostic value of miRNAs in sepsis RAN DGCR8 AGO2 DROSHA PMC9167543__F2 MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer JUN APC GSK3B WNT1 CTNNB1 PMC9389448__F3 Modes of action and diagnostic value of miRNAs in sepsis MAP3K7IP1 TIRAP TAB3 CD14 IRAK1 IRAK2 TRAF6 TNF IRAK4 MYD88 PMC3852967__F3 Interaction network of genes differentially expressed in response to glatiramer acetate (GA) SLC5A5 CXCL9 IL27 IL2RG IGFBP1 GHRH PTPRC ITGAV IL-21 PPBP HCST CYP2C19 IL18 POMC ADCY6 AgRP OXT ICAM2 XCL1 DEFA4 CXCL10 CD34 PTPRCAP TNFSF14 AIF1 VCAM1 TRAF2 PMC6886858__F6 A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus SLFN12 FAM72C STAT1 RBM43 PDIA4 DHRS9 STAT2 IRF1 IRF7 PMC6441925__F1 DNA repair pathways with mutated genes highlighted PMS1 BRIP1 MSH6 RARA RFC1 MSH2 MRE11A PCNA BRCA1 BRCA2 ATM PALB2 PMC7418032__F6 Autophagic Clearance of Active and Damaged Mitochondria in HSCs ATG10 ATAD3A PINK1 TSC1 ATG16L1 ATG12 TFEB BNIP3 FLCN MTOR ATG5 PMC8203498__F1 Representation of the signaling pathways involved in B-cell clonogenicity induced by clonogenic vp17s MSH2 RAF1 EGFR CDK2 JAK1 PMC7921306__F1 Genomic and non-genomic mechanisms of glucocorticoids IL10 IL6 TNF PMC3475172__F1 Model of canonical eukaryotic translation initiation pathway ELF2 EIF2A PMC6886858__F4 A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus STAT1 FAS IFIH1 PML IRF1 IRF7 CXCL10 PLK1 TNFSF10 CCL2 PMC3243350__F1 Biosynthetic pathway of oxylipins in Arabidopsis ECD COCH PMC6942823__F6 Inhibitory effect of Tt-ME in RAW264.7 macrophages STAT3 SYK TLR4 IRAK1 SRC MYD88 PMC3929501__F1 a) Digrammatic representation of follicle growth from the non-proliferating pool of primordial follicles RPS6 TSC2 TSC1 PTEN PMC2712786__F1 Pathways of extrinsic and intrinsic apoptosis, highlighting roles of Bcl-2 family members BAD BMF HRK BIK PMC10138595__F3 PGE2 Promotes Immunoregulation through Cross-Regulation between Beta-catenin and NFKB by Activating the Wnt-Beta-catenin Signaling Pathways APC GSK3B CTNNB1 PMC3064126__F6 PHEX, DMP1, matrix extracellular phosphoglycoprotein (MEPE), and ASARM peptides are proposed to dynamically regulate FGF23 expression in bone VIT DMP1 FGF23 PMC10138595__F1 Cytokine Storm and ALI/ARDS Induced by Influenza Virus Infection HMGB1 IRF3 IRF7 TLR7 MYD88 PMC12016489__F8 Two major complexes of the mTOR signaling pathway and their pathways RHEB MLST8 TSC2 TSC1 DEPTOR PMC6030168__F7 Hypothetical model showing that imbalanced LIMK1 and LIMK2 expression activates the WNT/Beta-catenin pathway and leads to CRC progression and EMT-induced metastasis LIMK2 LIMK1 CTNNB1 PMC1964754__F6 Furin in development, homeostasis and disease MMP2 FURIN EDAR PMC4440819__F7 DA-Raf-Mediated Suppression of the Ras—ERK Pathway Is Essential for TGFB1-Induced Epithelial—Mesenchymal Transition in Alveolar Epithelial Type 2 Cells ACTA2 SMAD2 FGF2 PMC7072529__F1 Hypothesised regulation of extracellular matrix composition by the cilium and ciliary proteins ACAN TIMP3 INTU PTCH1 IFT20 ARF4 SMO HEL-S-11 PMC5346543__F9 Diagrammatic presentation of the mechanism of EMAP-II in combination with TMZ suppressed malignant biological behaviors of GSCs via miR-590-3p/MACC1 inhibiting PI3K/AKT/mTOR signaling pathway MACC1 IGF1 MTOR PMC7696686__F6 The current working hypothesis PINK1 OPA1 MMP2 RHO RAC1 PMC6333051__F2 IL-6 signaling in the tumor cell of the bone marrow niche STAT3 GRB2 MTOR PMC5553399__F8 Proposed mechanism for G2 phase-specific nuclear export of CENP-F NUP133 CDC2 CENPF PMC3851442__F2 Transposable elements and their potential role in complex lung disorder TH APC PMC9420447__F7 Alpha-Momorcharin Inhibits Proinflammatory Cytokine Expression by M1 Macrophages but Not Anti-Inflammatory Cytokine Expression by M2 Macrophages TBK1 MAP3K7IP1 TLR4 CD14 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC8801426__F2 G Protein-Coupled Receptor Kinase 2 as Novel Therapeutic Target in Fibrotic Diseases ADRBK1 STAT1 IFNAR2 IRF1 AVP PMC10031257__F3 Focal adhesion proteins in skeleton and diseases STAT3 SOX9 MMP10 VTN ADAMTS5 SRC RUNX2 PMC7760926__F1 Role of oxidative stress in muscle wasting during cancer cachexia IGF1 JUNB ATF4 MTOR PMC6492276__F2 Biosynthesis of O-GlcNAc and UDP-GlcNAc OGA OGT GNPNAT1 GFPT1 PMC9408832__F3 Targeting the Sphingolipid Rheostat in Gliomas CERS3 CERS5 UGCG CERK ACER1 GBA2 SGPL1 CERS1 SGMS1 CERS2 DEGS1 SGMS2 DEGS2 SMPD1 KDSR SGPP2 SMPD2 CERS6 ASAH2 SMPD4 SGPP1 ACER3 PMC11896785__F2 Mass Spectrometry as a First-Line Diagnostic Aid for Congenital Disorders of Glycosylation COG5 VMA21 GMPPB SLC35C1 FUT8 DDOST MAN1B1 GANAB DPM3 ATP6AP2 PRKCSH MGAT2 STT3A ST3GAL3 ALG14 B4GALT1 DPM2 TUSC3 RFT1 ALG3 FCSK NUS1 SLC35A1 COG3 ALG5 MAGT1 SLC35A3 DOLK VMA12 ALG6 ATP6V0A2 ALG10 TRAPPC11 DHDDS SLC39A8 ALG13 DPM1 COG8 TMEM165 COG7 SSR4 COG2 SSR3 COG1 VMA22 STT3B COG6 OSTC PMC3060320__F2 Schematic illustration of signalling within the type I interferon (IFN) system SOCS1 IFNA7 CXCR3 STAT3 IFNA6 IFNA8 IFNA13 IFNA14 TIRAP IFNA16 IFNA10 IF1AA9 NRP1 TLR9 TRAF3 SOCS3 MYD88 IFNA21 STAT2 IRF9 TNFSF13 IRF1 IRF3 IRF7 IFNA2 IRF8 PIAS2 IFNAR2 IRF2 PDC MAP3K7 TNFSF11 CXCR4 TRADD TNFAIP3 IFNW1 IKBKE IFIH1 TANK AZI2 IFNK RIPK2 ZBP1 TNFRSF13C TLR4 TNFRSF17 TLR8 TLR7 TBKBP1 IFNA17 IFNA4 IRF4 TNLG2B SPP1 TLR3 IKBKB PIAS1 TYK2 FADD PMC9399520__F7 Celastrol ameliorates osteoarthritis via regulating TLR2/NFKB signaling pathway TIRAP COX2 MYD88 PMC8721241__F3 Updated role of ABA in seed maturation, dormancy, and germination MAPK11 SNRK ABI3 PMC5157899__F4 PEP-mediated metabolism in thermogenic cells of S PPIH MAL PMC2731675__F3 FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION CD40 BCR GC PC IL1A PMC4705593__F1 Cholesterol biosynthesis pathway HMGCR LDLR FDPS FDFT1 ABCA1 PMC7333652__F8 Microenvironment-related gene TNFSF13B predicts poor prognosis in kidney renal clear cell carcinoma APRT HEL-S-182mP TNLG7A EPN1 UCK2 HEL-S-61p MIF SRC LSM6 PMC8580647__F4 Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling SMAD1 TGFA SMAD2 SMAD4 RUNX2 PMC7226777__F1 Principal functions of the 18-kDa translocator protein (TSPO): initiation of programmed cell death, including apoptosis, as well as regulation of the cell’s nuclear gene expression BAX PBR MYC FOS CLK1 ID3 PMC2812698__F1 Signalling pathways that regulate cell wall remodelling of Candida albicans CDC42 MID1 PMC4572872__F2 Many anticancer agents mediate tumour cell killing though activation of the BCL-2-regulated apoptotic pathway BAX BAD BMF PMC9650829__F2 Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside CDH2 EPCAM EGF ADAM17 EGFR SOX2 FHL2 LEF1 CTNNB1 PMC9192945__F1 Myeloid Cells in GBM Immunosuppression STAT3 CD80 CXCL1 BATF2 CD14 MIF MMP9 CCL2 CXCL8 CD33 FGL2 IL8RB HEL-S-26 CD63 PMC5639307__F7 Summary of the study results with pathway SUFU SHH SMO RAC1 PMC8708027__F6 Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review CDK6 E2F2 EGFR MCL1 ITGB3 BAK1 SIRT1 SOX4 CDK4 PMC5012964__F3 Steroidogenic pathway HSD3B2 CYP21A2 HSD17B3 CYP17A1 CYP11A1 HSD3B1 HSD17B2 PMC8708027__F3 Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review BAX TSC2 BAD TSC1 MDM2 MTOR PMC6323488__F3 Different signaling pathways related to EGFR activation induced by CTGF/EGFR interaction CDC2 PCNA EGFR CDK2 CCNB1 PMC5012964__F2 Molecular pathways underlying the development of the male external genitalia HOXD13 HOXA13 BMP4 BMP2 SHH BMP7 FGF10 FGF8 CTNNB1 PMC4352987__F3 Multiple signaling pathways regulate the expression and activity of Sox9 during chondrogenesis GATA5 SOX6 SOX9 NKX3-2 SHH HIF1A GATA6 GATA4 SOX5 COL2A1 PMC4352987__F4 Different combinations of transcription factors drive tissue-specific gene expression in immature versus hypertrophic chondrocytes GATA5 SMAD1 DKFZp781O1323 SMAD2 NKX3-2 FOXA3 HIF1A COL10A1 VEGFA RUNX2 MEF2C RUNX3 COL2A1 SPP1 CTNNB1 MEF2D ACAN SOX6 SOX9 FOXA2 GATA6 GATA4 SOX5 PMC4352987__F5 Regulatory pathways downstream of BMP, Fgf18, CNP, Ihh or PTHrP signaling control chondrocyte proliferation and hypertrophy STAT1 SIK3 NPR2 IHH FGFR3 CNP PTH1R RUNX2 CCND1 FGF18 MEF2C MEF2D PMC9695474__F3 Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions MAVS STAT2 EGFR IRF9 IRF1 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR3 TLR7 TYK2 PMC8389606__F2 NFKB and Human Cancer: What Have We Learned over the Past 35 Years? LTBR BCR RELB CYLD MYD88 PMC8708027__F1 Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review TGFA EGFR PTEN GRB2 PMC7783549__F7 Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice HTRA2 BAD FAS CAD CASP2 CASP12 AIP TNF F3 MEI1 CASP3 ATF4 TRAF2 DIABLO FADD PMC7196462__F2 Roles of SMAD3 in the TGF‐B and the BMP pathway TF SMAD2 SMAD4 DROSHA PMC3632646__F2 Regulation of GLI1 the isoforms by the canonical and noncanonical pathways SAP18 SUFU PDGFRA GSK3B SHH SMAD4 SMO MDM2 PMC5546320__F5 Oxygen Availability and Metabolic Adaptations ATG3 ATG12 ULK1 BNIPL BNIP3 ATF4 BNIP3L ATG5 PMC12154332__F1 Barrel-like structure of ABO forms ion channels in the cell membrane, allowing Ca2+ to enter the cell TFAM SRC NRF1 SIRT1 PMC11605246__F8 Schematic explanation of the mechanism of action: the transformation into M2-like of spleen macrophages in patients with PH is activated, which in turn activates the Ras-Raf-MEK-ERK-c-Myc signaling pathway axis IL10 CD36 IL13 IL4 CD163 PMC12086986__F7 Magnolin mitigates CXCL10‐induced skin ageing CXCR3 GAL CXCL10 PMC12154332__F2 Serotonin and BDNF initiate neurogenesis CDK5 HEL-S-11 PDK2 BDNF PMC7843995__F5 CFMSN and associated drugs MAPK1 BCL2 IL6 VEGFA MYC KRAS PMC6825310__F4 Executable network model as seen in the BMA tool MAX EGF BAD ETS2 MCL1 BNIP3 EZH2 PTEN MYC CTNNB1 VHL COX2 CDK2 WNT1 MDM2 CDK4 PMC8750045__F1 Tight Control of Non-Canonical TGFB Pathways and MicroRNAs Downregulates Nephronectin in Podocytes TRAF4 SMAD2 SMAD4 MAP3K7 ARHA MTOR TRAF6 PMC6912965__F1 Underlying mechanisms of Tregs in PAH BMPR2 ARHA CCND1 PMC6966641__F1 Major pathways involved in muscle loss in cancer cachexia SMAD2 MTOR MYD88 PMC10853679__F7 Graphical abstract to present metabolic heterogeneity in central and peripheral tumour areas of LumA and LumB LPL PIK3CA PDK4 EGFR TYMS PLA2G2A PMC7106581__F2 Graphic summary of physiological activities of Fndc5/Irisin that are elicited through pathways other than MAP-kinase signaling STAT3 GDF8 ULK1 TLR4 FABP4 MTOR BDNF TRAF6 MYD88 PMC7017070__F1 MiRNA processing pathway DGCR8 XPO5 DROSHA PMC5855561__F9 Working Model for regulation of prostate cancer AHR CD84 CYP1B1 IL1B PMC7757024__F2 SIRT1 regulates neuroendocrine secretion TH TSHR SIRT1 S100B PMC7757024__F1 SIRT1 modulates glucose metabolism through regulating cell secretion UCP2 HEL-S-277 FABP4 SIRT1 PMC4090493__F6 Proposed mechanism by which -shogaol inhibits melanin biosynthesis TF MC1R PMC5716074__F7 “Prokaryotic Pathway” Is Not Prokaryotic: Noncyanobacterial Origin of the Chloroplast Lipid Biosynthetic Pathway Revealed by Comprehensive Phylogenomic Analysis LPA FAS HEL-S-5 PC PMC6539782__F1 Carbohydrate and protein metabolisms EGR1 PFKFB2 SLC7A11 SIRT1 PMC8897051__F2 Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions STAT3 MDM2 MTOR CTNNB1 PMC5716074__F1 “Prokaryotic Pathway” Is Not Prokaryotic: Noncyanobacterial Origin of the Chloroplast Lipid Biosynthetic Pathway Revealed by Comprehensive Phylogenomic Analysis LPA LPP GPT PMC2911501__F2 gp130-dependent cytokines promote axon regeneration and SOCS3 act as a critical negative regulator of the signaling pathway STAT3 CNTF LIF SOCS3 IL6 IRS1 PMC2911501__F3 PTEN-regulated signaling pathway BAX TSC2 BAD TSC1 PTEN MTOR EIF4E PMC7017070__F7 OncomiRs miR-221 and miR-210 and their impact on cancer cells HOXA1 CDKN1A VMP1 PTPN1 SMAD4 SCD5 MMP9 PMC7017070__F3 Important tumor suppressive miRNAs and their impact on cancer cells EZH2 CXCR4 KRAS PMC12007672__F8 Mechanistic illustration of KGF-2’s role in inhibiting inflammation and alleviating DED by regulating the HMGB1/TLR4 pathway HMGB1 NLRP3 TLR4 PMC3709783__F6 UV-induced cyclobutane dimers- structure (A) and repair by the Nucleotide Excision DNA Repair (NER) pathway (B) ERCC1 XPA DDB2 ERCC5 XPC PMC4955940__F1 T-cell activation is regulated by antigen presentation, as well as stimulatory and inhibitory co-receptors ZAP70 CD80 JUN LCK PMC6960141__F10 Proposed mechanistic model of FA-97 ameliorates DSS-induced colitis against oxidative stress by activating Nrf2/HO-1 pathway KEAP1 TLR4 NQO1 IL1B PMC8733961__F4 5q35 duplication presents with psychiatric and undergrowth phenotypes mediated by NSD1 overexpression and mTOR signaling downregulation TSC2 MTOR PMC2895369__F1 High-flux and low-flux systems of electron transfer pathways GPX4 FES GPX1 PMC8879487__F1 Utility of Genomic Testing for Hyperphenylalaninemia PCBD1 SPR TPH2 PAH JDP1 PMC5788639__F6 Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement IGF1 BRAF CCND1 PMC3061041__F1 Negative regulation of the IMD pathway EGFR POLE CYLD FADD PMC7611899__F1 Fibrosis development and signaling pathways TLR4 SMAD2 SMAD4 ADAM10 MTOR REL CTNNB1 PMC5250671__F1 Oncogenic pathways in glioma and possibilities for pharmacological interventions, relevant for the models described in this article RB1 PTEN MDM2 GRB2 MTOR HEL-S-26 CDK4 PMC3757428__F2 Growth factors mediated mTORC1 and mTORC2 activation RHEB TSC2 TSC1 PMC3374088__F1 Caspase-8 has a crucial role in the regulation of DRs RIPK3 TRADD RIPK1 TNF FADD PMC8913526__F1 Helminth and Host Crosstalk: New Insight Into Treatment of Obesity and Its Associated Metabolic Syndromes TNF IL1B PMC11651451__F2 Oxidative stress and inflammatory response leading to CHD associated with SLE PTX3 VCAM1 TNF PMC11651451__F3 Initiation and activation of inflammasome of NLRP3, and the production process of IFN-I NLRP3 IRF3 IRF7 TNF PMC6170174__F8 The role of Piezo1 and Gq/G11 proteins in endothelial response to different flow patterns PIEZO1 PDE4D SRC PMC2042025__F3 Notch pathway is a frequent target of insertion NUMB PSEN1 CCND1 PMC9146692__F3 Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models STAT1 TLR3 STAT2 TLR8 TLR7 PMC8160512__F8 Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells CFTR IL6 PMC4444590__F1 Mitochondrial complex I dysfunction in patients with BD could lead to increased release of superoxide anions, resulting in greater reactive oxygen species (ROS) production NLRP3 IL1B PMC4613458__F2 Signalling to eIF4E in cancer RICTOR MTOR EIF4E PMC10095454__F6 The mechanism by which SDC3 cooperates with the regulation of milk fat synthesis and inflammatory response PPARG TNF SIRT1 SDC3 PMC11484321__F7 Distinct methylome profile of cfDNA in AMI patients reveals significant alteration in cAMP signaling pathway genes regulating cardiac muscle contraction RYR2 TNC CACNG2 GHSR TIAM1 ADCY9 HRC CASQ2 PAK1 VIPR2 CACNA2D3 FFAR2 PMC7796410__F2 Peptide-Based Nanomaterials for Tumor Immunotherapy CD44 GEM HEL70 PMC4192274__F2 Genes from the PPAR signaling pathway that were in regions surrounding QTL associated with at least one trait using the Bayesian approach CYP4A22 RXRA FADS2 CYP4A11 PMC5869700__F6 Toll-like receptor signaling pathway CD40 TIRAP CTSK IRAK1 TLR5 IL6 MYC TRAF6 IRAK4 RAC1 MYD88 STAT1 TLR1 MAP3K7IP1 NFKBIA LBP UNK FADD PMC4789659__F4 Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo DYRK2 HIPK2 DAPK2 HIPK1 HIPK4 PMC9294428__F4 Discovering gene regulatory networks of multiple phenotypic groups using dynamic Bayesian networks NR1i1 PPARG SMAD1 JUN FOSB SMAD2 TFAP2A ATF2 FOS RARA NR2A1 CDK6 NFKBIA TBP PMC9536840__F7 Pathway impact and pathology of example disease genome-wide association studies (GWAS) hit CAD PCCB IMPACT PMC7020378__F9 Spatiotemporal metabolism in the apple fruit GIP ASPA PMC2743399__F3 Improved readability and performance with multi-scale information integrated in pathway visualization using metagraph DVL1 JUND FAS DTX2 NFATC2 GSK3B NUMB ATF2 PSEN1 PSENEN MAML3 RASA2 FST CTBP1 LFNG DLL3 HES1 DCN MAPKAPK5 HDAC1 NCOR2 RBX1 CREBBP GRB2 WIF1 PMC2662565__F3 Bipolar disorder: from genes to behavior pathways MARCKS BDNF CTNNB1 PMC4135953__F9 Network of genes in mice immunized with UV-V after SARS-CoV challenge PTX3 MMP14 ADM SLPI IKBKE TANK TLR9 IRF7 LIPG MYD88 PLAT INHBA TLR3 TNFAIP2 SAA2 PMC9425297__F10 The role of FAM72A in SHM and CSR MSH6 MSH2 UNG FAM72A PMC11920859__F1 Gli pathway-targeted Co(iii) Schiff base complexes inhibit migration of basal cell carcinoma cells† SUFU PTCH1 SMO PMC8753429__AF1 Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NFKB signaling pathway HMGB1 TLR4 PMC6955127__F6 Effects of AMI (92 mg/ml) on the mechanism of Raw264.7 cells infected with influenza virus TBK1 TLR3 IRF3 PMC7934404__F2 GBPs regulate host antiviral innate immune signaling pathways GBP4 GBP5 MAVS STAT2 GBP7 IRF3 IRF7 PMC9456027__F2 Factors and Pathways Modulating Endothelial Cell Senescence in Vascular Aging IGFBP5 FOXO3A FGF21 IGFBP1 SIRT1 SIRT6 PMC5041887__F6 Cell polarity signaling in the plasticity of cancer cell invasiveness CDC42 SMURF1 VANGL1 APC PTEN ARHA DAAM1 PMC5041887__F7 Cell polarity signaling in the plasticity of cancer cell invasiveness CDC42 SMURF1 PTEN ARHA FMNL2 PMC6372626__F6 Frequent genetic alterations in genes from angiogenesis pathway in UBC STAT3 FRS2 SOS1 PXN HIF1A MTOR KRAS FGF2 HRAS PLCG1 PLCG2 SOS2 FGFR1 ERBB2 FGFR3 APP SRC ADGRG6 PMC6856883__F3 The regulatory roles of lncRNAs in TAM by regulating classic signaling pathway MMP2 TRAF6 PMC6856883__F1 Regulatory roles of lncRNAs in TAM polarization STAT3 PMC1183194__F5 Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin CASP9 CASP6 CASP2 CASP4 DFFA CASP3 CYC1 APP DFFB BIRC2 APAF1 LMNA PMC1183194__F6 Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin RB1 JUN ARHGDIB CASP6 MAP2K4 DFFA FAF1 MAP3K7 DAO FADD PMC1183194__F4 Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin STAT3 STAT1 BAD CASP8 RAF1 HEL-S-102 CASP3 CSK BCL2 CYC1 TNF APAF1 PMC2358953__F2 Network diagram showing the checkpoint response to uncapped telomeres RAD1 RAD17 RAD9A PMC4666900__F1 Simplified pathway diagram showing the Leishmania-APC and T cell interaction STAT3 ZAP70 IL10 IL3 APC IL4 IRF3 MTOR IL6 IL5 IL6R IFNG STAT1 IFNAR2 IFNAR1 IL2 STAT4 LCK PMC3064222__F9 Proposed signal transduction pathways in NG following receptor activation with leptin and CCK-8 CCKAR STAT3 HEL-S-62p ATF1 ARHA PMC7606273__F1 Autophagy and UPR pathways as well as their interconnection in SARC-CoV-2 pathogenesis ATF4 MTOR PMC6202145__F1 Structure of hRLX2, hypothetical pathway intermediates of RXFP1/2 and the benefits of hRLX2 therapy in radiation cystitis TGFB1 TIMP4 ARHA RXFP2 PMC521130__F2 Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeasts TH GAL RPL18 PMC8941799__F1 Myocardial bioenergetics in the healthy and in the diabetic heart OGT HK2 HEL-S-162eP CPT2 PMC3517581__F7 Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal SH-SY5Y Cells BMPR2 PDE7B LAMA1 RECK PEG3 HEL-S-89n IL6 TNF C1orf21 ELAVL2 TAF9B GFAP NFE2L2 GNL3L BCL2 APLP1 MMD PMC9247467__F3 CD44 In Sarcomas: A Comprehensive Review and Future Perspectives CD44 MMP14 ADAM17 SOX2 ADAM10 MMP9 TWIST1 PMC9220066__F3 Therapeutic Aspects and Molecular Targets of Autophagy to Control Pancreatic Cancer Management RHEB TSC2 TSC1 ULK1 MTOR KRAS DEPTOR PMC6292558__F2 Bioinformatic analysis of differentially expressed proteins (DEPs) identified in this study RAF1 MMP12 LAMB1 KRT19 EZR COL4A4 SCG5 HSPB2-C11orf52 MMP24 MMP26 VGF STX18 DEHAL1 MMP2 MMP3 NRAS STX3A LPL MAPK1 MMP7 MMP10 MMP17 SNCA COL11A2 FAP RELN SCG2 CHGB HPGD MMP20 THBS4 RIMS1 VAMP2 TSHR CD36 POTEF GFPT1 MAP2 AKR1B10 COL3A1 DCLK1 SYNM VWF THBS1 KRAS DDC SPP1 MOS CALCA SYN1 MMP16 SPARC MMP11 POSTN PLIN1 COL4A2 COL4A1 GDAP1 TMSB4X RAB27A TIMP3 LAMC2 PENK NAMPT VCAN COL2A1 LOXL2 LAMB3 LAMB2 IGFBP7 PPL LAMA3 RET CISD2 SYN2 TNC COMP MMP14 TIMP1 ENO2 LAMA1 THY1 TIMP4 EGFR THBS2 BRAF THBS3 VTN CHAD TNR UNC13A MMP15 EEF1A2 CPLX2 PCSK2 FABP4 MMP9 PTPRN2 CD34 TG XB HEL-S-102 PMC6151487__F5 Representative modules of ESCC-related metabolic network AGXT2 IDI2 ACLY HEL-S-133P HAO1 DBT FNTA ASPA ABAT HADHB HEL-S-182mP SPTLC2 ACAT2 BCAT2 PC HAO2 PAH IDI1 GPT PMC8298003__F22 Skin as a critical window in unveiling the pathophysiologic principles of COVID-19 TF VWF HEL-S-62p ACE2 PMC7939748__F2 Molecular mechanisms of plant-based foods in the alleviation of NAFLD SIRT3 FAS KEAP1 MTOR PMC11892979__F1 Clinico-genetic Analysis of Adenosine Signaling Pathway in Drug-Resistant Epilepsy MAPK1 NT5E ADK ADARB1 CREB1 PMC7939748__F3 Molecular mechanisms of plant-based foods in the alleviation of AFLD BAX FAS CYP2E1 KEAP1 FOXO1 TLR4 CASP3 MYD88 PMC7245796__F4 Metabolites on post-translational modification of EZH2 protein ACLY OGT PGM3 PDC EZH2 PMC5206726__F1 Relaxation oscillations and hierarchy of feedbacks in MAPK signaling NF1 EGFR NF2 PMC4023047__F3 Role of POR in biosynthesis of androgens in classic and alternate pathways POR HSD3B2 SRD5A2 FDXR HSD17B3 STAR HSD17B6 CYP17A1 CYP11A1 FDX1 AKR1C2 PMC5431431__F2 DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer SOCS1 GREB1 KLF4 PPARG TNC EGF TGFB1 EPHA2 LAMA1 MYH6 SMAD2 PBX1 MYC CXCL8 KRT19 CTNNB1 ACTA2 PLAT INHBA CCND2 PAX2 PPARGC1A KRT7 TBX3 KDR HAND1 DLX3 MSX2 SOX17 JUN IRX3 KLF6 SLC4A7 SOX2 IL6 NPPA CRABP2 ADRB2 SKP1 IL6ST BMPER GATA4 PPL PMC5336163__F8 PAF-mediated endotoxin tolerance MAP3K7IP1 STAB2 TLR4 IRAK1 SOCS3 JAK1 TRAF6 MYD88 PMC7985098__F4 Effects of statin on NLRP3 inflammasome and TLRs pathways CCS NLRP3 MYD88 PMC3159112__F5 Ad signaling in endothelial cells ADIPOR1 ADIPOR2 TNF PMC6863963__F1 Conflicting roles of RASAL2 in different cancers CD44 TSC2 IPO5 SOX2 GSK3B MTOR VEGFA CTNNB1 PMC5743757__F1 Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets TIRAP TLR3 TLR4 TLR9 TLR8 CD14 TLR5 TLR7 LBP PMC5743757__F2 Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets STAT3 MYB RAN TIRAP IL6 IL6R PMC7985098__F1 Roles of NLRPs and TLRs pathways in atherosclerosis pathophysiology CCS LOX NLRP3 MYD88 PMC6997467__F1 Signaling pathway of ncRNAs in RA ECSIT TLR1 MAP3K7IP1 TRAF6 CTNNB1 MYD88 PMC8225153__F4 Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety CDC2 STAT3 BAX CDK2 MTOR CCNB1 CTNNB1 PMC8225153__F3 Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety ACHE IDE APP BDNF TNF PMC5679744__F7 Fgf10-Hippo epithelial mesenchymal crosstalk maintains and recruits lung basal stem cells CSA2 FGF10 WNT7B PMC8446765__F1 Dysregulated androgen synthesis and anti-androgen resistance in advanced prostate cancer CYP17A1 STS PMC5447318__F2 Infection of virus can stimulate airway epithelium and produce antimicrobiota defense through IL-22/IL-22R signaling pathway TLR3 TLR4 TLR9 S100A9 PMC4155893__F3 Positive feedback loop between EGFR and ERA36.Notes: A positive feedback loop has been confirmed that EGFR signaling activates transcription of ERA36 through an AP-1-binding site in the promoter region of ERA36 EGFR SRC CCND1 PMC7907040__F2 Major signaling pathways of GPCR subfamilies PGC CTNNB1 PMC4562327__F1 Transition of primordial to primary follicles BMP15 BMP6 FOXI2 FOXL2 KL WNT4 AMH FSHR GDF9 PMC4064064__F3 MicroRNAs and Toll-like receptor signaling pathway in hepatitis B virus infection TLR3 TLR4 TLR9 IRAK1 IRF3 TLR7 TRAF6 MYD88 PMC8395432__F2 SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection RP1 TMPRSS2 PARP1 PMC6528338__F5 An integrated gene interaction network built for genes related to wing dimorphism RPL8 RPL35 RPL18 FBL HEL103 GRWD1 PTEN RPL30 ALDH2 USP3 NOP2 LITAF RPL28 RBM19 EIF3M RPL27 RPL4 SPTBN5 PPAN HIGD2A FTSJ3 PMC8395432__F6 SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection TMPRSS2 TLR3 TLR4 TLR9 TLR8 TLR7 ACE2 PARP1 PMC6442574__F1 Focal forebrain IR/IGF1R DKO eliminates signaling by receptor homodimers and hybrids in hippocampus or central amygdala IGF1 GSK3B IGF1R GRB2 MTOR IGF2 IRS1 PMC8205700__F4 Mesenchymal stem cell-derived exosomes: a promising vector in treatment for diabetes and its microvascular complications TLR4 SMAD2 ZEB2 MTOR VEGFA PMC8035080__F4 Mycolic acid biosynthesis and recycling INHA COCH PMC9330582__F1 Effect of the Gut Microbiota on Systemic and Anti-Tumor Immunity and Response to Systemic Therapy against Cancer STAT3 TIGIT FOXP3 MTOR IMPACT PMC9659945__F1 Progress of protein synthesis factors eIFs, eEFs and eRFs in inflammatory bowel disease and colorectal cancer pathogenesis ID4 ELF2 ATF4 PMC9659945__F2 Progress of protein synthesis factors eIFs, eEFs and eRFs in inflammatory bowel disease and colorectal cancer pathogenesis EEF2 MTOR MYC PMC5976976__F4 Hypothetical diagram showing target sites for the action of curcumin (diferuloylmethane) in signal transduction pathway KEAP1 IL16 NQO1 MAF BCL2 APP PMC7594717__F8 Metabolic flux map for C MAL CIT PMC10450211__F2 Circular RNAs: novel actors of Wnt signaling pathway in lung cancer progression ITCH DKK1 CTNNB1 PMC10509026__F1 Schematic view of vitamin D (VD) signaling pathway mediated VD receptor (VDR) NR1i1 CYP2R1 CYP27B1 CYP24A1 PTH FGF23 PMC9996228__F2 Genetic control of meiosis surveillance mechanisms in mammals RNF212 BAX ATR SPO11 ATM PMC10450211__F1 An Illustration of the circRNAs that directly or through specific miRNA sponges activate the Wnt signaling pathway and play a role in the progression of lung cancer ZNF124 FGF7 BIRC6 NOVA2 FZD4 KLF8 PLAGL2 TNF SOX4 PMC6854078__F8 Proposed schematic representation of the signaling pathways involved in the redox regulation of inflammasome activation in G6PD-deficient cells NLRP3 TLR4 IL1B HEL-S-44 PMC9581482__F8 Proposed model of LXR inhibition by oxysterol misbalance contributes to inflammation and fibrosis in murine WD TG TIMP1 FASN ATP7B PMC9252087__F2 PCycDB: a comprehensive and accurate database for fast analysis of phosphorus cycling genes PURA DCD RPIA ADK PTS DUT PURB PMC4974116__F3 HCV dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy CXCL9 BAX UBQLN2 RRM2 CTSS BBC3 GBP1 EFNA1 CXCL10 CXCL8 SERPINB8 SOX9 PHGDH LCN2 CCL20 TM4SF1 PMC11652361__F1 Siglec-15 affects four key areas: bone metabolism, modulates infections caused by pathogenic microorganisms, immune regulation, and the pathogenesis of hematologic diseases CD44 COIL TRAF6 IL1B PMC9273851__F2 Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases TFRC IPP FTL KEAP1 GPX4 DHFR SLC7A11 DHODH PMC11652361__F2 Illustration of osteoclasts differentiation CD44 SYK TRAF6 PMC9626029__F4 Bleeding Propensity in Waldenström Macroglobulinemia: Potential Causes and Evaluation VWF LTA ADAM10 PMC7653364__F4 Dysregulation of A-to-I RNA editing promotes cancer progression GABRA3 DHFR IGFBP7 PMC6994382__F2 Gene-network for genes mapped to 16 variants which replicated in both Hispanics and African Americans IL15 CD2 CLEC16A DEXI IL12A TMED9 LMAN2 CLTCL1 CFH IL2RA CD46 CLTB IRF8 CTLA4 IL15RA RNP24 CR1 TMED10 CD58 CLEC2D IL2 CCR4 PMC9626029__F3 Bleeding Propensity in Waldenström Macroglobulinemia: Potential Causes and Evaluation SYK BTK PLCG2 PMC4976849__F1 Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis MTHFD1 RFC1 ABCC1 DHFR ABCC3 MTRR GGH HEL-S-70p ABCC2 FPGS ABCB1 ADA PMC7160326__F1 Different WNT signaling pathways APC ROR2 GSK3B LRP5 LRP6 ARHA DAAM2 DAAM1 CTNNB1 PMC7160326__F2 The proteins that underlie Robinow syndrome or omodysplasia (indicated in red) in the WNT/planar cell polarity (PCP) pathway DVL1 GPC4 FZD2 NXN ROR2 GPC6 DVL3 ARHA DAAM2 RAC3 DAAM1 PMC7160326__F3 Modulators of the canonical WNT signaling pathway that are involved in the regulation of bone mass in human disease DVL1 LRP4 APC GSK3B LRP5 WNT1 LRP6 CTNNB1 PMC1899878__F1 Regulation of dimorphism in C NRG1 TPK1 ECE1 CAP1 PMC7269828__F1 Predictive biomarkers for PARPi efficacy RAD51B CDK12 BRCA2 CHEK2 ATM FANCA PALB2 PMC5328506__F2 Programmed cell death as a defence against infection RIPK3 BAX ZBP1 TLR3 MLKL TLR4 RIPK1 FADD MYD88 PMC5328506__F4 Programmed cell death as a defence against infection IFNG RIPK3 NLRP3 MLKL RIPK1 TNF IL1B FADD PMC4114189__F1 Molecular pathway of the mechano-induction of tenascin-C MAL HEL-S-28 ARHA RHO PMC4981669__F5 Possible mechanism for the antagonistic effect of Lpp and RNA in innate immune stimulation in monocytes and macrophages TLR1 IL18 TLR8 TLR7 LPP TNF MYD88 PMC7110195__F1 Nucleic acid sensors inducing type I and type III interferons TBK1 CGAS DDX1 MAVS DHX36 NOD2 DDX41 MYD88 PMC4981669__F4 Possible mechanisms for the synergistic immune stimulation of TLR2 and NOD2 ligands TLR1 IL6 LPP MYD88 PMC9261320__F1 Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases ATF4 EIF2A XBP1 TRAF2 PMC2783518__F1 Wnt signaling and senescence: a tug of war in early neoplasia? LRP5 LRP6 CTNNB1 PMC9261320__F2 Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases C13orf34 ATF4 EIF2A XBP1 TRAF2 PMC2692400__F1 Hormone and nutrient signaling pathways modulating leptin translation RHEB TG TSC1 ELF3 IRS1 PMC5614756__F1 DJ-1 activates ERK1/2 signaling pathway TH HEL-S-44 PMC6154041__F3 The role of Wnt5a-Ror2 signaling in osteoclast differentiation JUN SP1 ROR2 PKN3 RHO PMC9207338__F1 Pathophysiological Role of Nucleic Acid-Sensing Pattern Recognition Receptors in Inflammatory Diseases TBK1 CGAS TLR9 AIM2 IRAK1 IRF3 IFI16 IRF7 TRAF3 TRAF6 MYD88 NLRP3 TLR3 TLR8 TLR7 IL1B PMC5533708__F6 TANC protein interaction network LATS2 TANC2 TANC1 ZYX SCRIB HEL-S-1 TNIK PMC7348178__F6 VEGI‐251‐induced TAM apoptosis TRADD TRAF2 PMC6397982__F8 HMG-CoA Reductase Inhibitors Attenuate Neuronal Damage by Suppressing Oxygen Glucose Deprivation-Induced Activated Microglial Cells COX2 IL16 LDLR PMC10977553__F6 Mechanism through which agarwood against RAS PIK3CA CSF1 TRAF3 SOCS3 CCL5 CCL2 MMP3 CYLD CSF2 CASP8 IL18R1 JUNB DAB2IP IRF1 TNF FOS EDN1 TRAF1 VCAM1 CCL20 MMP14 FAS TRADD TNFAIP3 ITCH MLKL CXCL1 NOD2 CHUK RIPK1 ATF4 MAP2K3 CEBPB IL1B JUN SELE LIF BAG4 VEGFD MMP9 PTGS2 IL6 CXCL6 RIPK3 IKBKB RELA CASP3 NFKBIA IFNB1 BIRC2 TRAF2 FADD PMC6834162__F2 Methotrexate (MTX) transporters, metabolic pathways and intracellular enzyme targets RFC1 DHFR GGH TYMS HEL-S-70p FPGS PMC3857329__F3 As discussed in the preceding sections, the catalytic activation method using HNTf2 allows efficient borylation with optimal substrates such as 22 TH NME2 PMC6834162__F4 MTX affects several signal transduction pathways implicated in the pathogenesis of rheumatoid arthritis (RA) IL15 IFNG IL2 IL1B PMC10560454__F1 tFNAs improve hUMSC chondrogenic potential through the regulation of the PI3K/AKT pathway ACAN SOX9 ARHA MTOR COL2A1 PMC8586713__F1 PTSD as an Endothelial Disease: Insights From COVID-19 BRD4 PLG FURIN ACE2 BRD2 PMC10508518__F5 KEGG simulated signaling pathway analysis OMD CASP9 CBL XK POLK LAT MAK APC MAL PMC3545297__F1 Energy metabolism in a typical mammalian cell GAL FAS PMC6784888__F4 Leveraging single-cell genomics to expand the fungal tree of life PC CP PMC8880811__F3 The Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas: An Update NF1 MTOR RET PMC3890531__F4 IGF signaling pathway STAT3 BAD IGF1 IGF1R GRN PMC6826966__F2 Mechanism of resistance to arsenic trioxide- all-trans retinoic acid (ATO-ATRA) therapy in APL FLT3 RARA BCOR F2 PML ZBTB16 MTOR TNF PMC9097844__F8 ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3B/Snail pathway driven by TGFB/Smad signals GSK3B MMP2 MMP9 PMC5110973__F4 Nitrogen-induced metabolic changes and molecular determinants of carbon allocation in Dunaliella tertiolecta LPA MME MAL PDC GIP ACD PMC9593054__F2 NLRP3-mediated pyroptosis in diabetic nephropathy FOXM1 GSDMD NLRP3 TLR4 SIRT4 MTOR SIRT1 PMC8774030__F1 Therapeutic Potential of Naturally Occurring Small Molecules to Target the Wnt/Beta-Catenin Signaling Pathway in Colorectal Cancer TNKS APC NOG NOTUM LRP5 LRP6 GPR49 LGR6 PMC6423768__F7 A schematic diagram of exosomal miR-128-3p based signaling pathway in CRC treatment BMI1 EZH2 TWIST1 PMC3931461__F1 Progress in molecular-based management of differentiated thyroid cancer BRAF PTEN MTOR PMC3506908__F4 Pathway analysis derived by comparison of the relative abundance of metabolites from sera derived from patients with locoregional CRC and liver-only metastases, as determined by GC-MS AEBP1 NRTN ITLN1 BPI MAPK15 CXCL16 CAMK1D CLEC10A G0S2 SPOCK1 PMP2 ZNF675 MAPK4 TFF2 IL17B KSR2 CAMK2N1 HAS1 RAB32 TREH EDAR CP AVP PMC3943494__F3 Ceramide Metabolic Pathway in Epidermis CERK SMS CERS2 PMC7503488__F1 Actions of metformin on immune cells, blood platelets and endothelium during the development of neurodegeneration disease: Metformin has multiple properties such as anti-inflammatory, antioxidant and antithrombotic properties VWF PF4 PMC9252100__F6 Curcumenol Mitigates the Inflammation and Ameliorates the Catabolism Status of the Intervertebral Discs In Vivo and In Vitro via Inhibiting the TNFA/NFKB Pathway IL1RL1 TRAF3 TNF PMC3848109__F3 TGF-ß fibrotic pathway SMAD2 PLG SMAD4 PMC9593054__F3 NLRP3-mediated pyroptosis in diabetic nephropathy GSDMD EGR1 NLRP3 TXNIP FOXO1 EZH2 MTOR PMC3011942__F1 Phosphatidylinositol 3-kinase-Akt (PI3K-Akt) pathway becomes activated via stimulation of receptor tyrosine kinases (RTKs) and the assembly of receptor–PI3K complexes CDC42 BAD GSK3B PTEN MDM2 PDK2 MTOR RAC1 PMC9593054__F4 NLRP3-mediated pyroptosis in diabetic nephropathy GSDMD NLRP3 KEAP1 ELAVL1 PMC5592666__F2 CoQ6biosynthetic pathway in S COQ7 COQ3 COQ2 COG7 COQ6 PMC9593054__F5 NLRP3-mediated pyroptosis in diabetic nephropathy NLRP3 IGF1 GSK3B EZH2 MTOR CPT1A PMC9593054__F6 NLRP3-mediated pyroptosis in diabetic nephropathy GSDMD NLRP3 PTEN METTL3 MTOR DDX3X SIRT1 PMC3112527__F3 Summary of the signaling pathway mediated by RET SHANK3 GRB7 GRB10 FRS2 GRB2 DOK4 SRC DOK5 PMC9550454__F6 Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach HEL164 SYK BCR CD19 MDM2 MYC RAC1 PMC9550454__F7 Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach HEL164 BAD C2 PENK NRBF2 SNCA APP HEL-S-11 FADD PMC10622993__F2 Common signaling pathways and ALDH1 expression in CCA CDH2 EBP EGFR SMAD2 APC GSK3B LRP5 SMAD4 MTOR CTNNB1 TGFBR1 PMC3279640__F1 Bi-potential gonad development to either testis or ovary CBX2 DHH NR5A1 CTNNB1 RSPO1 DMRT1 LHX9 WT1 EMX2 SOX9 SRY FST FGF9 FGFR1 WNT4 AMH GATA4 SOX8 PMC2586270__F6 Furin action in pituitary gonadotrope cells SMAD2 FURIN PMC3279640__F2 Known genes and pathways of the different cell types of the developing testis in mouse (modified from Wainwright and Wilhelm ) VNN1 HSD3B2 CITED2 DHH SOX10 CBLN4 INSL3 FGFR2 WT1 SF1 SOX9 SRY PTCH1 FGF9 WNT4 AMH NOTCH3 GATA4 SOX8 HES1 PMC4772163__F5 Gene dysregulation is restored in the Parkinson’s disease MPTP neurotoxic mice model upon treatment of the therapeutic drug CuII(atsm) OXT SHANK3 RAMP3 MYLK MAPK13 SPHK1 DDC MEF2C PMC3170587__F2 Microenvironmental genomic alterations reveal signaling networks for head and neck squamous cell carcinoma CRK CBLC CREM SRC LCK PMC4330468__F1 Molecular targets and associated therapies to block three immunosuppressive checkpoints in a malignant brain tumor (glioma) model CD80 APC CTLA4 PMC11740643__F5 Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis IFNG KLF3 EGFR CTSK SMAD4 CDK2 CYC1 APP PTEN INS SET PMC8187562__F13 Pre-clinical Evidence: Berberine as a Promising Cardioprotective Candidate for Myocardial Ischemia/Reperfusion Injury, a Systematic Review, and Meta-Analysis STAT3 BAX FOXO1 BNIP3 BCL2 PTEN MTOR HES1 SIRT1 NOTCH1 PMC6822710__F1 Mck1 kinase is a new player in the DNA damage checkpoint pathway CDC6 HEL-S-84 PMC8512456__F2 Tumor immune microenvironment in epidermal growth factor receptor-mutated non-small cell lung cancer before and after epidermal growth factor receptor tyrosine kinase inhibitor treatment: a narrative review RNF25 STAT3 CXCR6 AXL EGFR SMAD2 CXCL1 HEL-S-28 PTEN CXCL2 IGF1R CTLA4 CXCL6 SPP1 FOXP3 CXCR4 PMC6255705__F9 Schematic representation of metabolic reprogramming caused by the DAPAT mutation during diurnal cycle GAD1 D2HGDH CS PMC10551637__F1 Targets and applications of nanodrug targeting myeloid cells in osteosarcoma for the enhancement of immunotherapy NPS SIRPA CD47 PMC7301642__F5 ATG8-mediated selective autophagy pathways in plants NBR1 ORM1 PBR PMC8024584__F8 MAPK-signaling pathway with 5 selected genes (Ssk1, Pbs2, Ste11, Hog1, and Ssk2), known to be associated with response to osmotic stress CBL SELL GPD1 PMC4709637__F1 Exogenous avian leukosis virus-induced activation of the ERK/AP1 pathway is required for virus replication and correlates with virus-induced tumorigenesis MAX ECSIT JUN FAS RAF1 CD14 TRAF6 DAO FLNA NLK GRB2 BDNF TRAF2 ERI1 PMC3227962__F5 Targets for intervention in the TGFB1 pathway (partial list) [, , ] ROCK1 RHO MTOR PMC7559222__F7 SNORA71A/mRNA/pathway interaction network constructed and visualized by Cytoscape software AMY1A MRAP RPS21 LEP EPB42 SNRPA RPS14 GGH ALAS2 HBB LBP TNMD PMC10607711__F2 Propagation of pressure in the epidermis and certain mechanotransducers involving the modulation of mechanical stimuli in keratinocytes CASR PIEZO1 PMC2875073__F5 Albumin alters TGFB pathway gene expression LTBP1 STAT3 EGF SMAD1 DKFZp781O1323 MAPK9 RUNX2 MAPK3 TGFBR1 TGFBR2 BAMBI IFNG STAT1 INHBA FST NOG BMP4 FKBP1A WNT1 THBS1 JUN LIF SMAD6 TGFBR3 TNF FOS SKI SPP1 RUNX3 ENG NFKB1 CREBBP JAK1 LEF1 PMC3741150__F8 Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNFA Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells TFAM ECE1 TLR9 PMC7762580__F1 Fructose and glucose degradation pathways ALDOB SORD HEL-S-87p AKR1B1 PMC2386920__F7 IRF-5 in the innate antiviral response TBK1 RIGI TLR9 IRAK1 IRF3 TLR7 TRAF6 MYD88 PMC7762580__F2 Fructose contribution to the pentose phosphate pathway HEL107 RPE KHK ALDOB SORD HEL-S-87p AKR1B1 PMC7708042__F4 DNA breakage formation induced by G4 stabilization DNA2 FEN1 SSB PMC4390799__F1 For therapeutic modulation of the UPR ATF4 EIF2A XBP1 PMC8904388__F1 Multifaceted Roles of cAMP Signaling in the Repair Process of Spinal Cord Injury and Related Combination Treatments SLPI EBP ARG1 RHO PMC7699867__F2 Regulation between actin cytoskeleton and Yap/Yorkie at the apical cell cortex in Drosophila and in mammalian cells TRIO ARHGAP29 PMC11575037__F3 Figure shows selected subnetworks of the differential network for Liver tissue in Diabetes SOCS1 PPARG CYP2E1 OSM AGAP2 CCR2 PRKCZ ADAM28 CCL5 NRG4 IFNG CYP27B1 MME ADM2 NLRP3 USP18 CCR7 POMC GCK F2RL1 TRIB3 TINCR AGTR1 AIM2 TNF GPR84 ATF3 DNAJC27 TMEM26 NAPSA LY86 GPER CCL4 LCN2 CCL20 NPPC KCP HGF ACACA TBX21 ABCA1 RORA MPO MERTK PCSK9 NCR1 TREM2 SIRT3 SHBG CX3CR1 CCR6 DPP4 AMH DUSP14 ACE2 CD248 ARG1 STEAP4 NR3C2 RIPK3 NRG1 PDE3B RORC TRPM2 SARM1 AQP9 ABO STAT4 CD8A CD3E ADA PMC5215839__F2 Posttranscriptional mechanisms of regulation of the miRNA biogenesis pathway DGCR8 TUT4 DROSHA PMC11575037__F5 Figure shows Selected subnetwork of the differential network for Aorta tissue in Diabetes TIRAP CYP2E1 OSM AGAP2 CCR2 TLR9 PRKCZ ADAM28 ATF2 NRG4 DOCK2 OGG1 GRB10 MME ADM2 NLRP3 USP18 CCR7 POMC FNDC4 GCK TRIB3 TINCR LPL DCD FITM2 IL34 IRF1 TNF ANGPT2 IRS1 TMEM26 NAPSA LY86 DUSP12 PAQR3 DKFZp666G145 AGTRAP TRAF1 CCL4 LCN2 SIRT1 NPPC EGF KCP FAS HGF EGFR MLKL ENPP1 TBX21 ABCA1 NOX4 RORA MPO MERTK DHRS9 CX3CR1 IRAK3 BMP4 DPP4 LDLR ATM AMH ACE2 ARG2 MAFB ARG1 IRF4 STS NR3C2 RIPK3 SOCS7 NRG1 NR1C1 NLRX1 TRPM2 TLR3 ABO LIPE STAT4 CD3E ADA PMC7803379__F1 Non-redox cycling mechanisms of oxidative stress induced by PM metals KEAP1 HEL-S-162eP EGFR PRX PMC8558403__F2 Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications TLR4 CCL4 CCL2 PMC3433910__F1 Putative scheme of the cellular metabolism in the hydrogen producing arachaeon T APRT PGP AIP PC PMC11575037__F7 Figure shows selected subnetwork of the differential network for Heart tissue in Diabetes ALB NAPSA POLM ADM LIPE ATM ACACA CCL2 ADA PMC9564177__F1 KEAP1-NRF2 System and Esophageal Cancer KEAP1 NQO1 GCLC GSK3B PTEN PMC1288546__F1 Human SHH-PTCH-GLI pathway (left) and its links to human diseases (right) GLI3 PMC4156318__F2 ATM-NFKB-regulated signaling network causing the adaptive resistance to IR in normal human skin epithelial HK18 cells ATM CCNB1 CCND1 PMC7387173__F3 Segregation of acute activity and cell transcriptional gene expression in POMC and NPY/AgRP cells GHSR INSR LEPR POMC PC TRPC5 NPY AgRP PMC4837871__F2 Sex-determining Region of Y Chromosome-related High-mobility-group Box 2 in Malignant Tumors: Current Opinions and Anticancer Therapy STAT3 EGF EGFR SOX2 SMO ABCG2 CTNNB1 PMC12155444__F6 Composite Enzyme-Gene Network of Key Metabolites and Targets TH LTC4S PLD2 DGKB FLJ10842 DGKG BAAT UGDH DGKD LAP3 RELA DGKE UPP2 DGKZ TYMP ADA PMC9043895__F3 Corrigendum: The Role of Histone Lysine Methylation in the Response of Mammalian Cells to Ionizing Radiation RAD51 ME1 VCP KDM4A ME3 BARD1 HDAC1 L3MBTL1 tal-1 BRCA1 ME2 RNF168 KDM2A SETMAR PRC1 RNF8 MBTD1 PALB2 HDAC2 PMC9569498__F1 O-GlcNAcylation in Renal (Patho)Physiology OGA OGT PGM3 PMC3607541__F6 Interleukin-1 alpha modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil CXCL5 CCR2 CCL7 IRF7 TLR7 IL8RB CCL2 MYD88 PMC9310808__F1 Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides cthGAMP TBK1 CGAS INA IRF3 PMC5609887__F5 Integrated analysis profiles of long non-coding RNAs reveal potential biomarkers of drug resistance in lung cancer BMPR2 SNAI2 SKIL GLIPR1 PLAUR MAPKAPK3 CTHRC1 FRMD6 HBEGF ADAMTS6 COL1A1 INHBE COL27A1 NRIP3 MATN3 JARID2 PMC6072829__F7 Zyflamend and NFKB pathway UBC MMP2 MMP9 CCND1 PMC4263263__F2 Metacore analysis of leading edge genes CDC20 APC PLK1 SKP2 PMC4586784__F2 Modes of signaling in Hh pathway-dependent cancer HHIP PTCH1 SMO PMC4263263__F3 Metacore analysis of leading edge genes MAPK14 BAX JUN HEL-S-11 ATF4 XBP1 TRAF2 ERAS PMC9603940__F6 Microbe-Derived Antioxidants Reduce Lipopolysaccharide-Induced Inflammatory Responses by Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1B Signaling Pathway NLRP3 SFN IL1B PMC7662987__F5 Schematic display of antitumor activity of CUDC-907 hybrid drug against prostate cancer cells RRM1 RRM2 WEE1 MYC PMC11602063__F15 ROS promote ginsenoside biosynthesis under water stress IPP HMGCR PMC5466420__F10 Illustration depicting the roles of Yap in submandibular gland epithelial development LATS1 LATS2 EREG KRT14 EGFR PMC8875669__F2 Biosynthesis and the Roles of Plant Sterols in Development and Stress Responses IPP DHCR24 SI SMO SSR2 PMC9028838__F1 MicroRNAs: Novel Targets in Hepatic Ischemia–Reperfusion Injury SOCS1 SIRT3 MARCKS SMAD4 TRAF6 CXCR4 MED1 SIRT1 PMC8238121__F1 PARP Inhibitors in the Ovarian Cancer Microenvironment: Moving Forward From Synthetic Lethality TBK1 CGAS RAD51 CCL5 CXCL10 PMC8050411__F5 Enriched canonical pathways of the DEGs associated with the p53 signalling pathway identified by IPA, showing gene expression and predicted relationships between top regulated 311 nm UVB DEGs at 6 h and 18 h post-irradiation BAX ATR JUN PAN2 PCNA JUNB PML ATM PTEN PIGS TIGAR HP PMC11938626__F6 Oncogenic mechanisms of HBsAg mutants in hepatocarcinogenesis SHB LHB CDK2 MTOR VEGFA CDK4 PMC8050411__F6 Enriched canonical pathway of IFN transcriptomic pathway identified by IPA, showing gene expression and predicted relationships between molecules differentially regulated by 311 nm UVB 18 h after irradiation IFNG BAX IFITM2 PSMB8 IRF9 IFIT3 IRF1 MX1 OAS1 PMC11938626__F2 HBsAg induces the HCC tumorigenesis by promoting proliferation RAF1 APC GSK3B SRC CCND1 CTNNB1 PMC11938626__F3 Various oncogenic effects induced by the ER stress in the development and progression of HBV-related HCC ACLY FGF8A STAT3 ACSL3 SHB LHB FADS2 ATF4 MTOR VEGFA XBP1 TRAF2 PMC4392845__F1 13C Isotope-Assisted Methods for Quantifying Glutamine Metabolism in Cancer Cells FH GLS OGDH CS HEL-S-26 PMC4904011__F1 Protein pathway driving the migraine process at the tripartite synapse COX2 PRRT2 SNAP25 FHL5 ASTN2 MEF2D PMC3553975__F8 Subnetworks identified from (a) Loi et al MAPK1 STAMBP PPARG JUN RXRG MAPK8 FOS NCOR2 RUNX1 GRB10 STAT5B GRB2 DNTTIP2 BCL6 MAPK8IP2 TDG PMC3553975__F6 Subnetworks identified from (a) Wang et al TP73 UBE3A UBE2G2 CDC20 PCNA PGR PML CCNA2 TGFBR1 HDAC3 GMNN TGFBR2 CD44 RBL1 MCM7 CDKN1A PRC1 CDK2 BCL2 SMURF2 POLD2 PMC8704137__F4 Ferroptosis in Non-Small Cell Lung Cancer: Progression and Therapeutic Potential on It SLC3A2 SLC7A11 HEL-S-64p HEL-75 PMC9715766__F2 Gut microbiota, pathogenic proteins and neurodegenerative diseases TREM2 CGAS NLRP3 TLR4 MYD88 PMC9245541__F2 How Do Pollen Allergens Sensitize? IL25 CD80 TSLP IL33 CD1D PMC1525234__F6 Working model of regulatory mechanisms controlling cell death in response to mating pheromones HMFT1766 GLS MID1 PMC5257007__F3 Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers FH PCCA MAL PCCB PMC3523822__F1 Biosynthetic pathway of diphthamide in eukaryotes DPH1 DPH2 DPH6 DPH7 DPH3 DPH5 PMC5040452__F13 Impact of Heat Stress on Cellular and Transcriptional Adaptation of Mammary Epithelial Cells in Riverine Buffalo (Bubalus Bubalis) IFNG TH TGFB1 CSF2 CXCL2 TNF CSF3 PMC3929252__F1 Estrogen, HER2 signalling, and the PI3K/Akt pathway in drug-resistant breast cancer.Notes: ER can activate gene transcription by nuclear translocatin following ligand binding (1) or as a result of receptor phosphorylation in the absence of ligand (2) BAD GSK3B PTEN IGF1R SRC PMC10296711__F12 Schematic illustration of the IL1-R/TLR/NFKB pathway with emphasis on activation of different NFKB subunits via the IRAK1/TRAF6-mediated pathway TAB3 IRAK3 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC10296711__F10 Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer AURKA TBK1 SOX2 TLR9 KLK3 IRAK1 EZH2 IRF3 IRAK2 IRF7 MYC TRAF6 IRAK4 CD47 MYD88 TLR1 TLR3 TLR4 IRAK3 TLR8 TLR7 TLR10 PMC7174405__F1 Key proteins and important processes in vertebrate HH signaling pathway SUFU PTCH1 DISP1 SMO PMC2820748__F6 Sites within the early steps of the insulin signaling pathway affected by OGT and O-GlcNAcylation STAT3 OGT SP1 PMC7827067__F2 Pathway map of PIK3CA/AKT CDC2 BAD VBP1 MYO3B MYO3A GSK3B VTN PTEN MINK1 SHE CR1 HRAS PDPK1 RELA NFKBIA MAPK7 ERBB2 CDK2 CDK14 CFTR CDK3 GRB2 PMC5379071__F4 Proteogenomic integration reveals therapeutic targets in breast cancer xenografts PAH PMC7417632__F7 Hypothetical molecular mechanism of the H19/miR-29a/Wnt signaling pathway in HF inducibility of DP cells DKK1 APC GSK3B LRP5 LRP6 CTNNB1 PMC2867902__F6 A feed forward loop for nutritional regulation of PNPLA3 FAS PNPLA3 SCD ELOVL6 PMC4303448__F1 The IKB kinase complex in NFKB regulation and beyond CSA2 MAP3K7IP1 PMC8353268__F4 Quantitative developmental biology in vitro using micropatterning NOG NPB NODAL PMC8826716__F10 Transmembrane p24 trafficking protein 2 regulates inflammation through the TLR4/NFKB signaling pathway in lung adenocarcinoma TLR4 EGFR RNP24 PMC9310369__F1 Main mechanisms of mitochondrial DAMP signalling P2RX7 BAX PANX1 TBK1 CGAS MAVS ERAL1 RELB APC TLR9 IRF3 IRF7 TNF CD1D TFAM AGER RELA MITA IFNB1 BAK1 IL1B PMC4598605__F5 Diagrammatic representation of mammalian target of rapamycin pathway: A crucial intersection of type 2 diabetes and Alzheimer’s disease RHEB GRB2 MTOR PMC4852538__F2 Pathway association between TH and metabolic process via ABCC8 (Kir6.2) (A) MAPK1 JUN MAPK11 FOSB MAPKAPK2 FOS MAPK3 MAPK14 ATF3 PRKACG ABCC8 SP3 SHH ATF1 FOXA2 PMC10311505__F3 YAP at the progression of inflammation TBK1 CGAS RIGI MAVS IRAK1 IRF3 TRAF3 TRAF6 PMC4970609__F10 Roles of hBVR in activating IRK/PI3K/Akt pathway BACH1 GSK3A IGF1 PMC6468556__F4 Model for HCV assembly and release DGAT1 DGAT2 ABHD5 APOE PMC3854349__F1 Biochemical adaptations of mammalian hibernation and naturally induced reversible insulin resistance PDK4 IRS1 PMC10033682__F3 Ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway MATK FURIN MMP11 STS NISCH POR RARA NR1B3 HEL-S-69p CNR2 WAS STK16 CSK MMP2 ACE2 PMC12180163__F13 Pathways of action of ESPs intervention to alleviate UC in mice IL25 EGF MUC2 IL33 WNT3 TNF PMC10033682__F4 Ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway FLT3 MMP14 EGFR MCL1 GSK3B BACE1 PTPRF NOX4 MGA ALDH2 DRD2 DRD4 SHBG AHR MMP2 ABCG2 CDC2 PIM1 MMP9 SAE1 CXCR1 GSK3A ADK CCR4 BCL2 XDH PMC3216306__F1 Downregulation of macrophages signalling by Leishmania infection TBK1 TIRAP TLR4 CD14 IRF3 IRAK2 TRAF6 IRAK4 MYD88 PMC6338098__F2 TGF-beta signalling in bovine mammary gland involution and a comparative assessment of MAC-T and BME-UV1 cells as in vitro models for its study BAD TGFB1 SMAD2 SMAD4 PMC4801794__F2 PI3K/AKT/mTOR signaling pathways RHEB TSC2 RICTOR TSC1 HEL-S-28 PTEN MTOR IRS1 PMC11435552__F1 Suppression of Interferon Response and Antiviral Strategies of Bunyaviruses TBK1 MAVS RIOK3 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 ISG20 TLR3 GC HP ISG15 PMC4158873__F2 O-GlcNAc and cancer metabolism OGT FAS GLS HEL-S-133P HEL-S-68p HEL-S-162eP ENO1 SCO2 MTOR PMC5082879__F3 Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models STAT3 RFC4 ADAMTS4 PCNA MYBL2 DNTT NUFIP1 FRAS1 CCT4 MYC DOK1 CCNG1 BTRC NPM1 TGFBR3 SDC1 ITGB3 PMS1 MLH3 C1QA BRCA1 CHEK1 ERBB2 CDC27 SDC2 TRAF2 YWHAZ CP PMC11435552__F2 DBV and GTV suppressing the IFN antiviral system by NS sequestration of key signaling molecules into IBs or FSs TBK1 STAT1 MAVS TRIM25 STAT2 IRF3 IRF7 PMC4158873__F3 PI3K/Akt/mTOR signaling pathway RHEB OGT TSC2 RICTOR TSC1 PTEN MTOR EIF4E PMC5082879__F2 Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models FGF13 NCAPG MYBL2 DIRAS2 DNALI1 CENPE KCNN4 ZNF185 NEDD9 HBG1 STAT1 SOX9 PBRM1 SLC29A1 FHL1 SPRY1 CENPF RPS23 SPRY4 SORL1 DUSP4 KRT23 SLC7A2 CYP1B1 NR2F1 SPRY2 TG MAJN CRLF1 MFAP2 CRABP2 PMC10216404__F2 Effects of RSV on activation of SIRT1 signalling pathway SOX9 MSC NFATC1 RUNX2 SIRT1 PMC9007691__F6 Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer EMP1 RAC1 PMC12246835__F3 Underlying renoprotective mechanisms of anthraquinones by regulating IƙB/NF-ƙB, Keap1/Nrf2 and PI3K/Akt/mTOR signaling pathways OGT KEAP1 GCLM PTEN MTOR EIF4E RHEB TSC2 RBX1 TSC1 LOX NQO1 GCLC PMC4471883__F7 TLR4 signalling pathway to alleviate microglial activation BAX TLR4 BCL2 IL1B MYD88 PMC10216404__F4 Effects of RSV on the regulation of microRNAs and BMP2 signalling in protecting bone BMP2 MSC RUNX2 NOX4 PMC12246835__F2 Underlying renoprotective mechanisms of anthraquinones by inhibiting TGFB1/Smad and Wnt1/Beta-catenin signaling pathways SMAD2 APC LRP5 SMAD4 LRP6 CTNNB1 TGFBR1 PMC11172918__F4 Ouabain–NKA-induced changes in epithelial cultured cells MDCK MTOR SRC PMC8219020__F1 Live-attenuated oral polio vaccine as a potential source of protection against COVID-19 – Review of literature CD226 TIGIT APC PMC5625110__F1 Src family kinase signaling in renal fibrosis STAT3 FYN EGFR SRC PMC7583949__F2 Macrophages in cardiac fibrosis NRG1 IL10 CD14 CCL4 TNF PMC4564869__F3 Quantitative Phosphoproteomics Reveals Crosstalk Between Phosphorylation and O-GlcNAc in the DNA Damage Response Pathway OGT SCX PMC11172918__F3 Different signaling pathways activated by the binding of CGs and ROS to NKS ORAI1 STIM1 EGFR MTOR SRC PMC7549352__F1 miRNA biogenesis: the canonical pathway begins with the transcription of miRNA genes to form the pri-miRNA ELF4 DGCR8 PAN2 PAN3 DROSHA PMC6870983__F2 Schematic model of the mechanism of HuR-regulated tumor cell migration TGFB1 SNAI1 UGDH RAB31 EGFR MMP9 SIRT1 PMC6079259__F2 Mechanism of Homologous Recombination (HR) RAD51 ATM PMC4578617__F1 miRNAs that control signaling governing osteogenesis and adipogenesis SMAD1 BMP2 MSC CTNNB1 PMC7864218__F3 Intersection of Mechanotransduction and Regenerative Osteogenic Materials CDC42 APC ARHA NLK CTNNB1 PMC8532088__F2 Influenza virus RNA polymerase as an innate immune agonist and antagonist NBR1 TBK1 MAVS TRIM25 RNF5 IRF3 IRF7 TRAF3 TRIM35 PMC10755185__F6 Transcriptome Changes and Metabolic Outcomes After Bariatric Surgery in Adults With Obesity and Type 2 Diabetes BAX CFI EPO NAMPT APP AGTRAP ADAM10 PMC2824768__F4 Entry into an ICL repair pathway depends on the mode of recognition REV1 MPG DDR2 XPC PMC8000576__F2 Mechanisms by which MYC induces apoptosis MAX BAX BRD4 MDM2 MYC APAF1 PMC8000576__F1 BCL-2-regulated apoptotic pathway BAX BAD BMF HRK BIK PMC8430060__F5 Gene expression patterns of neuronal cells reveal the pathogenesis of autism MME HLA-G EGFR IL6 VEGFA PMC3513217__F2 Schematic illustration of irinotecan disposition pathway UGT1A1 UGT1A9 ABCC1 APC ABCG2 CYP3A4 ABCC2 ABCB1 PMC3513217__F3 Metabolism pathway of tamoxifen and its interaction with estrogen receptors.Copyright © 2009 CYP1A2 CYP2B6 SULT1A1 CYP2C19 CYP2C9 CYP3A4 PMC9243258__F4 R-loop Mediated DNA Damage and Impaired DNA Repair in Spinal Muscular Atrophy ATR SETX BRCA1 H2AX ATM SSB PMC11556706__F1 Phase regulation of Ca2+-cAMP oscillation and corresponding mathematical modeling CSA2 AKAP10 PMC2666503__F1 F igure 1.— FRS2 GRB2 PMC9260753__F6 Network Pharmacology Experiments Show That Emodin Can Exert a Protective Effect on MCAO Rats by Regulating Hif-1A/VEGF-A Signaling HEL-S-22 TNKS2 NR1H2 CYP2E1 EGFR TLR9 DRD3 MAOA CYP3A7 CYP3A43 RIPK2 CDK6 ALOX5 NR3A2 AHR KDR ABCG2 BCHE ABCB1 CA14 CYP1A2 CES2 AXL CA13 HEL-S-133P FASN LDHB CA5B CYP1B1 MIF TNF PTP4A3 STS AURKB RELA ERBB2 BCL2 XDH CYP3A4 LCK PMC4087671__F1 Control of the TRAF6 signalosome by miR-146a STAT1 IRAK1 TRAF6 CXCR4 IRAK4 MYD88 PMC7791871__F7 YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas LATS1 LATS2 PTEN MTOR PMC5548460__F1 Beyond transcription factors: how oncogenic signaling reshapes the epigenetic landscape LMO2 PMC3423122__F10 Transcriptome of genes encoding enzymes and proteins on the lactose synthesis pathway, including GLUT1, HK1, PGM1, UGP2, GALE, GALT, SLC35A2, LALBA, and B4-GALT1, -3, and -5 B4GALT1 SLC35A2 LYZG PMC3423122__F11 Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans PRLR STAT3 STAT1 SLC35A2 SP1 EPO IRF1 CEBPB PMC8217661__F2 Wiskott-Aldrich Syndrome Protein: Roles in Signal Transduction in T Cells APC CRKL ITK PMC2483283__F2 Coexpression of genes within three core metabolic pathways IVD ACP4 BCAT1 AGL ACP5 PMC8267412__F2 Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer GPC5 WNT3A CTNNB1 PMC8267412__F3 Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer PSD4 ARF6 SDC1 KRAS PMC6912266__F1 Potential intracellular target points for (i) acute alcohol and (ii) chronic alcohol in a stylized cell LTB CD40 NLRP3 RELB IRAK1 TRAF6 REL LBP IRAK4 MPO MYD88 PMC3860520__F3 Toll-like receptor (TLR)-4 signaling pathway in alcoholic liver disease TBK1 TIRAP IRAK1 IRF3 TRAF3 TRAF6 IRAK4 MYD88 PMC7687005__F8 Mechanistic diagrams indicate that in osteoporosis, miR‐497 could promote osteoblast proliferation and collagen synthesis, and inhibit osteoblast apoptosis through inhibiting LRG1 and activating TGF‐B1/Smads signalling pathway HMFT1766 SMAD2 SMAD4 PMC2483283__F4 Coexpression of the genes for fatty acid biosynthesis ACP4 ACP5 PMC6009972__F11 ML141-induced hepatocyte differentiation CDC42 ALB WNT3A CTNNB1 PMC2483283__F5 Leucine degradation pathway in mitochondria IVD MCC BCAT2 BCAT1 PMC9607901__F3 Recent advances in the diagnostic and therapeutic roles of microRNAs in colorectal cancer progression and metastasis STAT3 TRADD EGFR MCL1 SMAD2 APC GSK3B SMAD4 PTEN HIF1A MTOR TNF CTNNB1 CCND2 TRAF2 CCND1 PMC8908266__F1 Deubiquitinases in Virus Replication and Host Innate Immune Response OTUD4 TBK1 CGAS OTULIN TLR9 TRAF3 TRAF6 OTUD1 MYD88 USP15 USP27X USP4 USP18 USP1 TLR8 TLR7 OTUB2 CYLD USP25 USP19 IRF9 TLR5 IRF3 IRF7 USP49 OTUD3 TLR1 USP2 USP20 PMC7891831__F1 Enzymatic cascade of the renin-angiotensin system (RAS) and the key receptor systems ACE2 PMC5050041__F1 Neuregulin 1 - erbB4 pathway in schizophrenia: From genes to an interactome DTNBP1 NRG1 FYN PSD RGS4 GRB2 SRC DISC1 AKAP9 PMC10548138__F2 PI3K /Akt in COPD regulation IL6 TNF PMC4114321__F3 Regulation of homologous recombination in eukaryotes CIB4 CIB3 ATR CIB2 ATRIP RAD51 PCNA BRCA2 ATM CLN3 PMC10548138__F1 Transduction and regulatory pathways of PI3K/Akt pathway INPP4B PTEN PDK2 PMC6325760__F1 Schematic diagram showing PR/RANKL pathway and downstream RANK-mediated signaling in mammary epithelial cells EGF ID2 EGFR CCND1 TRAF2 PMC6995173__F7 NAMPT’s role in the proliferation of human CRC cells through the regulation of Wnt/Beta-catenin signaling APC NAMPT CTNNB1 PMC3189169__F1 Toll-like receptor (TLR) and type I interferon (IFN) signaling pathways TBK1 IFNA8 STAT2 IRF9 TLR9 IRF3 TRAF3 MYD88 STAT1 TLR3 TLR8 TLR7 JAK1 TYK2 PMC11786412__F7 Reconstruction the sex determination regulatory pathway involving amhr2 DMRT1 HSD11B2 WNT4 AMHR2 AMH PMC8195904__F2 Adamantinomatous craniopharyngioma as a model to understand paracrine and senescence-induced tumourigenesis RNF43 APC ZNRF3 CTNNB1 PMC8458763__F5 Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease PIEZO1 SMAD2 ANXA2 PMC6450552__F2 Systematic illustration of PGRN-mediated signaling pathways STAT3 EPHA2 FOXO4 PMC8392110__F1 Targeting STAT3 Signaling Pathway in Colorectal Cancer STAT3 EGF SOCS3 SRC PMC9496369__F1 Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives EGFR VCAM1 PMC9522619__F7 Properties of flavonoids in the treatment of bladder cancer (Review) CD44 HEL-S-53e NRBP1 FGFR3 PTEN MDM2 MMP9 MTOR TNF SIRT1 PMC6041267__F8 A schematic model of mitochondrial distribution regulated by the Arf6–AMAP1–ILK pathway PRKD2 TRAK1 RHOT1 ARF6 TRAK2 HEL-S-28 PMC9522619__F2 Properties of flavonoids in the treatment of bladder cancer (Review) ATG101 BAX FAS TRADD STEAP3 GPX4 ATG14 MTOR TNF FADD PMC9522619__F3 Properties of flavonoids in the treatment of bladder cancer (Review) STAT3 SMAD2 PTCH1 SOX2 GSK3B LRP5 SMAD4 SHH LRP6 SMO CCND1 CTNNB1 PMC9522619__F5 Properties of flavonoids in the treatment of bladder cancer (Review) STAT3 FTH1 MMP2 ATF4 MTOR SRC PLK1 PMC3412276__F1 Mannose metabolism in Trypanosoma brucei PMC9522619__F1 Properties of flavonoids in the treatment of bladder cancer (Review) CDC2 ATR CDK2 ATM PLK1 PMC3962548__F4 Controlling clot formation TF TFPI APC PC PMC3798018__F1 PLD and phosphatidic acid in the cell RHEB TSC2 TSC1 NME2 PLD2 PC RHO GRB2 MTOR SRC LPP PMC8329951__F6 Identification of differentially expressed genes in diabetic kidney disease by RNA‐Seq analysis of venous blood platelets HDC CAD LIF IL5RA ddo DPYS IL2RA IL20RA IL15RA PMC3354586__F3 Ingenuity pathway analysis (IPA) identified critical expression networks containing genes that are significantly correlated with the extent of necrosis in The Cancer Genome Atlas (TCGA) glioblastoma (GBM) samples from all subclasses (A and B) ZFP36 STAT3 JMJD6 TNFAIP3 NPC1 PLAUR RELB S100A8 SLC2A3 RAC1 ITGAM KSR2 RAF3 CD163 CEBPB PMC5027135__F4 A new model of MC4R microcircuitry POMC MC4R AgRP PMC5432127__F1A Maternal obesity on placental function and fetal development NR1C1 ADIPOR1 ADIPOR2 MTOR IRS1 PMC3275548__F3 Liver from Campari tomato treatment PPARG IMMT RNPC3 SMAD2 MGLL PDE4B DHODH TGFBR1 CTNNB1 RB1 TACC3 NR1B3 MTX2 F2 PAX2 FARSLA LDLR MTX1 KIFC1 IL2 MAPRE2 HEL-S-32 ITPR2 SLC1A1 CACNB1 LMO2 YES1 MAPRE3 APC DPH5 SREBF2 FLOT1 E4F1 ARG1 TNF NR2A1 ALDOB NR2F2 FHOD1 FOXO1 BBS7 ANKH IL13RA2 PMC3890531__F5 VEGF and NOTCH signaling pathways GC FLT1 VEGFA NOTCH2 NOTCH3 NOTCH1 PMC8448420__F2 Autophagy and Mitochondrial Homeostasis During Infection: A Double-Edged Sword ECSIT TIRAP IRF3 TRAF3 MTOR TRAF6 PMC5362546__F2 Long non-coding RNAs in nasopharyngeal carcinoma: As systemic review RAB10 RAB11B PFN1 RAB11A E2F3 EZH2 ARHA PMC9496180__F8 Fibrotic Response of Human Trabecular Meshwork Cells to Transforming Growth Factor-Beta 3 and Autotaxin in Aqueous Humor LPA STAT3 COL1A1 RHO PMC8259730__F1 Precision Medicine for Paediatric Severe Asthma: Current Status and Future Direction [Corrigendum] IL25 TSLP IL33 PMC2761106__F8 BMP7 signaling in the NZ SMAD1 DKFZp781O1323 BMP7 ATF2 ID1 PMC2743934__F8 Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD EEF2K EEF2 ARC PMC2990979__F1 Portions of the pathway utilized in Beta-branching are highlighted with color in this depiction of the bryostatin biosynthetic pathway C7 HEL-S-5 UNK PMC8346058__F2 Targeting Inflammation after Myocardial Infarction: A Therapeutic Opportunity for Extracellular Vesicles? S1PR1 ADAM17 NLRP3 IGF1 C1QA CCR2 IRAK1 TRAF6 MERTK MYD88 PMC7255381__F4 Signaling of the VEGF Ligands, Receptors, and the Inhibitors of the VEGFA Pathway VEGFB PIGF NRP1 NRP2 VEGFA PMC3427656__F1 GH-STAT5 signaling pathway IGF1 CDKN1A CDKN2B GHR PMC7016858__F1 Biogenesis and heterogeneity of tumor-derived extracellular vesicles CD81 AGO2 CD9 CD82 CD63 PMC7924189__F6 Mechanism of rice blast resistance in Tetep at cellular level TF MYB ERF LPO PMC3910266__F2 NOD1 signaling and interactions with Rho GTPases and NFATc CDC42 RIPK2 NOD1 HEL-S-11 RAC1 PMC7854028__F1 miRNAs participate in the regulation of key genes related to cellular response to IR BAX ATR PRKDC EGFR ATM PTEN MTOR PMC8931289__F9 Tear miRNAs Identified in a Murine Model of Sjögren’s Syndrome as Potential Diagnostic Biomarkers and Indicators of Disease Mechanism SOCS1 CD40 STAT3 MYB GADD45G CDCA4 TNLG7A MCL1 ARF6 TMEM100 SOCS3 TRAF6 COXFA4 MAPK3 CLVS1 SALL4 CCNE1 OMP FGFR1 APLN A2M CDKN3 AID MAPKAPK2 GSKIP SYDE2 PSMD7 SPRED1 PIP4P1 BCL2 GRB2 AK4 HEL-S-103 GRIN2B RNF144B AKT3 KDSR TFRC PNP CCND2 CASP5 INSR PHKB HELZ MTMR11 RPL14 LSM11 RBM6 CCND1 DGCR2 DESI1 UNK NPRC CAMTA1 CMC4 CRP SDCBP2 TFCP2L1 PLSCR4 FAM32A CACUL1 HLA-DQB2 ARL2 CDKN2AIP PTCD3 CD14 POLR3F TADA1 CYB561 RORB FGF2 ENSA CHEK1 HDAC8 LBP TRAF2 PMC12058831__F5 Investigation of the mechanism of Buyang Huanwu decoction in improving learning and memory impairment in Alzheimer's disease mice based on lipidomics AGPS GNPAT CHPT1 PMC2746747__F1 Molecular ablation of TGFB signaling pathways by tyrosine kinase inhibition: The coming of a promising new era in the treatment of tissue fibrosis SMAD1 SMAD2 SMAD4 TGFBR1 PMC5709847__F2 Regulatory mechanism of expression of DNA damage response genes by the checkpoint pathway PMC7854028__F3 IR-induced modulation of miRNAs initials carcinogenesis BAX BCR PTEN PMC5709847__F1 Checkpoint cascade in S PMC9393691__F4 Metabolic rewiring directs melanoma immunology AHR FOXP3 LAG3 PMC6113440__F3 Modified chlorambucil (Chb‐M') as a safe lead compound of novel anticancer drug therapy RUNX1 CBFB RUNX2 RUNX3 PMC9157603__F6 Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology TH REN PROB1 PMC6528848__F1 Different regulatory mechanisms of BANCR in different human malignancy HDAC3 CDH2 TSHR MMP2 EZH2 NOTCH2 PMC6639196__F4 Conceivable migration pathway related to PNETs based on literatures MMP7 CLEC3A PKP3 LCN2 MTOR PMC5532371__F8 A possible pathway for pre-miR-199a-mediated regulation of HSV-1 secondary envelopment CDC42 ARF1 ARHGAP21 PMC7730500__F1 Schematic diagram illustrating the steps and enzymes involved in the base excision repair (BER) pathway TDP1 MPG NEIL2 FEN1 PCNA PARG WRN NEIL3 NEIL1 BLM PARP1 OGG1 PNKP SF1 LIG1 MUTYH PARP2 MBD4 SMUG1 TDG PMC5922992__F1 Nucleotide-binding oligomerization domain 1-mediated mucosal host defense against Helicobacter pylori infection CXCL9 CXCL11 IRF7 NOD1 TRAF3 CXCL10 CXCL8 PMC7317091__F1 Summary of osteoclast differentiation induced by integration of CSF-1R, RANK, immunoreceptor-like and integrin receptor signaling TREM2 SYK CSF1 VAV3 PLCG2 OSCAR NFATC1 GRB2 TRAF6 CSF1R PMC11492689__F1 Roles of non-coding RNAs (ncRNAs) in host response to PRRSV infection SOCS1 STAT3 TBK1 MAVS STAT2 SRP14 IRF9 IRF3 IRF7 SOCS3 TNF IRAK4 RAC1 STAT1 TLR3 CD151 TLR7 CD163 TYK2 PMC8501630__F5 Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors RHEB RPS6 TSC2 EIF4B TSC1 INSR PC RHO MTOR ELF3 EIF4E PMC11492689__F2 Roles of ncRNAs in host response to PRRSV infection IFNAR2 AKT3 IRF1 IRF7 PMC9613904__F8 Proteostatic consequences of PKB/Akt-mTORC1 pathway manipulation in muscle TSC1 ULK1 IRS1 PMC11837477__F10 EGFR roles in fetal and postnatal pancreas development EGF HBEGF ADAM17 EGFR BTC MTOR SRC RAC1 PMC11010095__F8 The pivotal role of CTRP9 in reendothelialization of EPCs and the protective mechanisms of AMPK‐mediated Akt/eNOS signaling involved in adipoR1 and N‐cadherin receptor CDH2 ADIPOR1 ADIPOR2 PMC9355085__F3 Epigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity VIT DNMT3B RICTOR APC RELB GSK3B IRF4 FOXP3 MTOR SATB1 BIK TGFBR1 PMC11834966__F3 Action of PRMT3 and CARM1 in different cancer PFKFB4 MPG PRMT3 HEL-S-133P ST7 GPX4 CDCA4 FACL4 LRRFIP2 EZH2 HIF1A MTOR VEGFA YY1 MYC CTNNB1 CUL4A CARM1 NFIB HEL-S-162eP GC TFEB METTL14 HEL-S-32 PMC6337236__F2 Iron handling in the tumor microenvironment TF STAT3 EGF SMAD1 DKFZp781O1323 SMAD4 HAMP BMP6 IFNG HEPH LCN2 CD163 IL1B PMC9198488__F2 Key Role of RNA Modification in Breast Cancer CDH2 AURKA IGF2BP1 C5AR1 IGF2BP3 YTHDF1 SMC1A DROSHA CTNNB1 ALKBH5 WTAP YTHDF2 METTL14 KRT7 ENO1 METTL3 IGF2BP2 STC1 GJA1 PMC5727541__F4 2-hydroxyisobutyrylated enzymes involved in TCA cycle, pentose phosphate pathway, pyruvate metabolism, glycolysis/gluconeogenesis and starch biosynthesis pathways HEL107 RPE SDHA DLAT FH HEL-S-304 RPIA OGDH HEL-S-162eP DLD PMC11837477__F13 EGFR roles in lung fibrosis EGF ADAM17 EGFR AREG PMC4713620__F2 Model of RNF43-regulated p53 cell cycling pathway RNF43 MDM2 CCND1 PMC2955448__F1 Pathogenesis of prostate cancer: from molecular to metabolic alterations ACLY MAPK1 FAS HMGCR PTEN PMC10539878__F3 Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease CASR IL1R1 PYCARD GSDMD MAVS NLRP3 MFN2 PTMS TNF FADD BRCC3 PMC2896848__F2 Alternate and peripheral androgen synthesis pathways STAR CYP11A1 STS PMC8465606__F7 Ascorbic Acid Regulates the Immunity, Anti-Oxidation and Apoptosis in Abalone Haliotis discus hannai Ino TRAF4 TIRAP TLR4 IRF3 TRAF3 TRAF6 IRAK4 UNK IL1B MYD88 PMC2784121__F6 NPM-ALK oncogenic tyrosine kinase controls T cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells CDC42 ZAP70 STAT3 VAV3 LAT VAV1 ARHA RAC1 LCK PMC12217521__F6 The paracrine effects of Mac-ADSCs PIK3CA HGF IL11 IL6 VEGFA PMC3131451__F1 The PI3K/mTOR signaling pathway highlighting the phosphorylation sites tested in our cellular and biochemical assays PTEN MTOR PMC10040407__F8 Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure TH GPX4 FACL4 PMC8792742__F2 Inflammasome Activation in Pulmonary Arterial Hypertension HMGB1 GSDMD TLR4 IL1B PMC9372260__F4 Integrated analysis of multiple bioinformatics studies to identify microRNA-target gene-transcription factor regulatory networks in retinoblastoma BRIP1 RAD52 CDC20 CDC6 RRM2 TYMS GTSE1 MCM7 CTPS1 CDC45 MCM3 MCM6 MCM2 PMC6522569__F2 Beyond PD-1 Immunotherapy in Malignant Melanoma IDO1 LAG3 PMC4413906__F2 Progesterone receptor signaling in the initiation of pregnancy and preservation of a healthy uterus TF PGR SRC PMC6568338__F8 Adhesion-dependent and -independent pathways leading to DNA synthesis in ET-1-treated astrocytes RHO GRB2 SRC PMC9688773__F8 Lipid Dys-Homeostasis Contributes to APOE4-Associated AD Pathology HMGCR PEMT DHCR24 PC DHCR7 PCYT2 PMC10535041__F5 Antagonistic Activity of Oroxylin A against Fusarium graminearum and Its Inhibitory Effect on Zearalenone Production FH HEL-S-304 RPIA ACO2 PMC3621013__F5 Control of Alternative Splicing in Immune Responses: Many Regulators, Many Predictions, Much Still to Learn CD44 FASTK LEF1 CELF2 PMC2770326__F6 Selective pathway utilization of analogs is ensured by the nonpermissivity of enzymes at critical junctures RENBP GNE FPGT DPAGT1 GALK2 PMC12034657__F4 PI3K/AKT/mTOR signaling pathway activated by Sr CASR SP2 MTOR PMC2770326__F4 Pathway options for sialic acid glycoengineering GNE COCH NANS PMC7952251__F2 Regulatory mechanism of aromatase and '2-cell, 2-gonadotropin hypothesis' IGF1 SMAD2 IGF1R FSHR CEBPB PMC5864864__F7 Proposed model of the temporal contributions of Wnt ligands and Beta-catenin to Alpha-galactosylceramide (Alpha-GalCer)-induced interferon gamma (IFNG) and IL-4 responses by liver natural killer T (NKT) cells DKK1 APC SFRP1 CTNNB1 PMC9539487__F4 Partners in crime: Proteins implicated in RNA repeat expansion diseases RAN DHX36 ELAVL1 EIF3B EIF2D EIF2A CAPRIN1 PMC4443896__F1A Activation of the JAK/STAT pathway in Behcet’s Disease GAS GRB2 MTOR CEBPB PMC11595439__F3 The CWI signaling cascade HMFT1766 SP1 RHOT1 COIL ATF1 PMC3500439__F1 Molecular Pathways: The Metabolic Regulator Estrogen-Related Receptor Alpha as a Therapeutic Target in Cancer TSC1 IGF1 IL4 YY1 MTOR PMC7911116__F2 Lithium interactions with oxidative stress, inflammation and glutamatergic pathways GSK3B BCL2 BDNF PMC2871634__F5 Regulation of apoptosis FAS CAD TRADD PAK1 TRAF2 FADD PMC8157630__F6 Identification of significant genes as prognostic markers and potential tumor suppressors in lung adenocarcinoma via bioinformatical analysis CDC42 CAD LAT RHO OTP PMC4319431__F1 Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions GALNT3 BAX FUT6 FUT3 TRAF2 FADD PMC7911116__F1 Activated and deactivated WNT pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC4085981__F1 Positive feedback in cardioprotection: Can more mechanism lead to translation? RPS6 RICTOR PC MTOR PMC2620272__F4 Bimodal genes that were switched "on" as a result of HIV infection in KEGG T-cell receptor signalling pathways CRB2 FYN CDA CD36 LAT ITK CTLA4 DAO LCK PMC3071786__F6 Changes in mRNA levels among various signalling pathway members following inhibition of FGFR activity FZD10 AKT3 XBP1 CTNNB1 FGF7A FZD8 ATF4 SPRY1 SNAI2 GPC4 FRS2 APC FZD7 TBX6 FGF5C TBX4 ARHA ZIC3 CDX4 SPRY2 POU3F1 ATF3 FZD4 PDGFRA NOTUM HDAC8 EDNRB CREBBP WNT3 SNW1 ELK3 GRB2 FGF18 PMC9251686__F7 Receptor interacting protein 1 knockdown induces cell death in liver cancer by suppressing STAT3/ATR activation in a p53-dependent manner STAT3 TOPBP1 ATR RIPK1 PMC6527808__F1 Molecular pathogenesis of Epstein-Barr virus-positive NK/T-cell lymphoma ECSIT HACE1 FOXO3A PTPRK MYC DDX3X PMC8416054__F2 Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease CD40 CD80 TNFAIP3 CD72 RASGRP3 TLR9 IRAK1 IRF7 CTLA4 TNF MYD88 BLK PTPN22 ITGAM LILRA2 PDC CSK STAT4 TLR7 LYN FCGR2A PMC8416054__F3 Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease CD44 CD40 CD80 PTPN22 FAS TRAF1 FOXP3 TRAF6 PMC2819165__F2 Genetic Susceptibility to Lymphoma BCL2L1 IL10 LEP CCND2 TLR4 NFKBIA IL6 IL10RA TNF CCND1 PMC2770326__F2 Mammalian sialic acid metabolism ST8SIA4 NANP ST6GAL2 ST3GAL6 NEU3 ST8SIA5 ST6GAL1 NEU1 ST8SIA6 ST8SIA1 CMAS ST8SIA2 NANS ST3GAL1 SIAT4C NEU2 GNPNAT1 NEU4 GNE PGM3 ST6GALNAC2 KL ST3GAL3 ST6GALNAC4 PMC11058230__F7 A hypothetic model for signaling pathway alterations and cellular phenotypes in MPS II neurons MMP7 SCN9A CACNA1A P2RX3 KCND2 FOSL1 NEFL AXIN2 CTNNB1 PMC5861197__F3 Paradigm of host inflammation responses to Salmonella and its interaction with autophagy as well as ubiquitination NLRP12 TRAF3 TRAF6 IL1B MYD88 PMC8168445__F1 Reactive astrocytes are a key component to neuroinflammation in AD STAT3 EBP FOXO3A PMC5861197__F4 The similar activation process of autophagy and NFKB pathway in response to Salmonella SHARPIN OTULIN OPTN PMC5343350__F7 Potential mechanisms involved in T helper type 17 (Th17) differentiation under T‐bet over‐expression conditions IFNG RUNX1 AHR IRF4 PMC6873406__F9 Non small cell lung cancer KEGG pathway BAX CASP9 BAD RASSF1 POLK EGFR JAK3 ERBB2 FHIT DAO PMC3366822__F7 Schematic diagram showing the role of NDRG1 in inhibiting the EMT via regulation of the TGFB/SMAD and Wnt pathways SMAD2 SMAD4 CCND1 CTNNB1 PMC3851951__F4 Microbiota impact on the epigenetic regulation of colorectal cancer LTA TIMP3 RUNX3 PMC6767051__F2 Cell cycle‐non specific mechanisms for the resistance to CDK4/6 inhibitors CDK6 SMAD2 SMAD4 CDK2 PTEN ZEB2 MTOR CDK4 PMC7408838__F2 SRC-mediated molecular pathways formally assessed in malignant mesothelioma (MM) STAT3 POSTN CDK6 SRC CCND1 CDK4 PMC2871634__F4 WNT/Beta-catenin signaling pathway FRAT1 FRZB APC GSK3B CCND1 CTNNB1 PMC7819563__F3 Correlation between glucose metabolism and amino acid metabolism in tumor cells GLUD1 ASS1 HEL-S-133P PHGDH GPT2 HEL-S-26 PMC6333678__F2 Signaling pathways activated after binding of E2 and G1 to GPER EGF EGFR SRC CCND1 PMC5809440__F2 Assessment of liver microenvironment through whole-genome RNA Seq CD80 TBK1 IFIT1 IFIT3 IFIH1 IFIT2 IRF3 IRF7 TRAF3 OAS3 MYD88 MAP3K7IP1 IFI44 IFITM3 STAT4 ISG15 OAS2 EIF2AK2 PMC11294417__F10 Schematic diagram for NEK2 functions during porcine embryonic development CDC2 APC NEK2 LRP5 LRP6 MYC CTNNB1 MRE11A BRCA1 PRKDC CHEK2 CHEK1 CDK2 CCNB1 PMC6245977__F1 RAS signaling pathway with proteins mutated in JMML in red CBL GRB2 MTOR GAB2 PMC7281231__F7 Schematic representation summarizing the impacts of PEDV ORF3 on NFKB and IFNB signaling cascades TBK1 MAVS RELA IRF3 IRF7 IL6 PMC6632210__F7 LPS-mediated platelet activation and TLR4 expression in canine platelets COX1 TLR4 CD14 CS LBP PMC7343769__F1 Molecular mechanisms of chloroquine/hydroxychloroquine in pDCs CD80 CGAS MAVS TLR9 TLR7 IL6 TNF MYD88 PMC9320269__F4A Analyzing the Systems Biology Effects of COVID-19 mRNA Vaccines to Assess Their Safety and Putative Side Effects CORT HLA-B HLA-A PMC7488754__F1 Scheme of processes that maintain a certain receptor density on the postsynaptic membrane at the activated synapse RHEB SHANK3 TSC2 TSC1 PMC8347170__F2 Autoimmune Responses in Oncology: Causes and Significance CD80 PMC3992631__F3 Comparison of gene expression in immobilized relative to planktonic yeast: (A) intermediary metabolism and (B) cell cycle ACO2 ENO2 HEL-S-68p PDC HEL-S-32 ENO1 HEL-S-4 MDH2 CDC34 HEL-S-26 ADH5 PMC10526805__F3 Phosphoinositide Signaling by Scaffolds at Cytoplasmic Membranes IQGAP1 PMC10526805__F2 Phosphoinositide Signaling by Scaffolds at Cytoplasmic Membranes LAPTM4B NEDD4 ARF1 MAP4 EGFR ARF6 DAB2IP IQGAP1 PTEN PMC8470522__F3 Actions and Roles of FSH in Germinative Cells LIN28B GDNF BMP4 ID4 BCL6B BCL2 FSHR RET PMC4685420__F1 Schematic summarizing some of the genes and pathways known to influence c-Myc cap-independent translation in multiple myeloma (MM) IGF1 RPS25 IL6 MTOR PMC7819563__F2 Metabolic alterations in hepatocarcinoma OXCT1 HEL107 CUEDC2 HEL-S-133P PMC9424728__F9 Integrating physiology, genetics, and transcriptome to decipher a new thermo-sensitive and light-sensitive virescent leaf gene mutant in cucumber POR CPOX UROD UROS PMC4694793__F3 Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy HGF EGFR BCL2 SMO PTEN MTOR PMC7841926__F4 Illustration of the calcium signaling pathway induced by major putative targets of SMT PLN CAV3 CAV2 PMC12203940__F1 Wnt signaling pathways APC LRP5 LRP6 RYK ARHA RHO CTNNB1 PMC4964175__F1 Pharmacological targets of ibuprofen HEL-S-62p RGMA ARHA PMC5890536__F9 RFc constructs on human complement HEL-S-62p C2 C4A CP PMC8106045__F1 Physiology and pathophysiology of copper transport and metabolism ATOX1 ATP7B CP PMC4227521__F1 Erythropoietin receptor and signaling pathways STAT3 STAT1 BTG1 EPOR EPO GRB2 SHE PMC3980740__F5 Signaling circuit driving transformation and tumorigenesis STAT3 IL6 NOTCH3 SRC PMC1782564__F6 Hypothesized asthma cascade in hapten immune contact sensitized mice, consist of B-1 cell- to immunoglobulin M- (IgM) to complement-driven airway responses AHR CS PMC4553261__F1 Data slicing and pathway enrichment analysis COX2 APP SET PMC9654339__F3 In Vivo Models for Prostate Cancer Research SPOP NSD2 PTEN ERG PMC9654339__F4 In Vivo Models for Prostate Cancer Research BRCA1 PTEN ACSS3 MDM2 HOXB13 MYC MGMT PMC9654339__F5 In Vivo Models for Prostate Cancer Research MAX MMP7 STAT3 RIPK2 ALK FZD2 APC BRAF PTEN MYC CTNNB1 PMC4653709__F12 Proposed schematic representation showing the mechanism of ETH and its effect on neurogenesis GSK3A APC CTNNB1 PMC11950527__F3 Annotated map of EM on PCa-related signaling pathways USP25 FLT3 TH S100A7 TRAF3 CCL2 POLK CCL7 MMP3 LCN2 CCL20 TRAF2 FADD PMC7603200__F4 Connection between the PI3K/AKT/mTOR pathway and GLI activity RHEB GSK3B PTEN DEPTOR GLI3 PMC8281607__F2 Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation GNPAT FAR1 TMEM86B PEMT PMC11854706__F6 Signaling pathways induced and inhibited by ACE PARD6A PIK3CA BAD TRADD EGFR CYCS GSK3B PIK3R1 PTEN CTNNB1 CCND2 CCND1 APAF1 CCND3 CASP9 CASP8 APC TNF KRAS RAC1 AXIN2 PARD3 PARD6G PARD6B CASP3 AXIN1 BCL2 CASP10 FADD PMC8467449__F3 Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer PCSK9 CYP17A1 HMGCR LDLR SOAT1 SREBF2 ABCA1 PMC4198363__F5 A role of autophagy in PTP4A3-driven cancer progression SQSTM1 MTOR ATG5 PTP4A3 PMC7603200__F2 MTOR pathway MTHFD2 RHEB CAD GSK3B TBC1D7 PTEN DEPTOR EIF4E PMC7286374__F3 Primary pathway of steroidogenesis and enzyme inhibition by posaconazole (P) CYP21A2 STAR CYP17A1 CYP11B2 CYP11A1 PMC8505360__AF1 Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis ULK1 ATG14 MTOR HEL-S-44 PMC12211798__F7 Proposed model of IGF2BP3 joined in autophagy mediated TNBC metastasis with m6A-dependent molecular mechanisms AAG1 MTOR PMC7275878__F1 Genetic basis of pneumococcal and staphylococcal infections: inborn errors of human TLR and IL-1R immunity SHARPIN TLR1 TIRAP IRAK3 TLR9 IRAK1 TLR5 TLR7 TRAF6 TLR10 IL1B MYD88 PMC3508562__F1 Diagram representing the possible endogenous and exogenous TLR activation pathways and the accompanying response.Abbreviation: TLR, toll-like receptor TLR4 TNLG7C PMC3508562__F2 Genomics in cardiovascular diseases: analysis of the importance of the toll-like receptor signaling pathway TBK1 TIRAP TLR9 CD14 IRAK1 TLR5 IRF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 TLR7 PMC11206721__F1 Nutrition-related signaling pathway leading to diabetic nephropathy SIRT3 FAS NR1C1 ELMO1 FOXO3A MTOR SIRT1 PMC6241696__F4 Regulatory network of FSH to cervical cancer GSK3B CASP3 FSHR PMC9576970__F2 Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach PLVAP PRODH PMC4127169__F2 Wnts organize presynaptic (CNS and NMJ) and postsynaptic (NMJ) specializations through multiple signaling pathways MUSK GSK3B RAC1 CTNNB1 PMC9576970__F3 Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach CXCL11 ABCG5 SP1 NPC1L1 CXCL1 SREBF2 CXCL8 PMC9404373__F1 Metabolomics in rheumatoid arthritis: Advances and review STAT3 LOX HK2 PDC PC MMP9 IL1B FGFR2 PMC9576970__F4 Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach MMP7 STAT3 JUN SLC3A1 MMP12 CXCL1 PTGS2 IL6 TNF IFNG STAT1 NFKBIA IL8RB IL1B PMC8119379__F2 De-coding genetic risk variants in type 1 diabetes CD226 PLN ZAP70 CD80 CTSH FUT2 IFNG STAT1 NOD2 IL18 IL2 APC IRF3 CXCL10 CD47 CBL TLR3 IFNAR2 ABO IFNAR1 SIRPA UBASH3A JAK1 TYK2 LCK PMC5226501__F1 Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease LATS1 LATS2 PMC6967385__F2 Mouse gene expression affected by biofilm status LPL UBC AQP7 HEL-S-28 PLTP CPT2 PMC261890__F8 T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression LAT ITK MTOR SRC LCK PMC3583110__F2 Intrinsic and extrinsic apoptotic pathways BAX TRADD FADD PMC7086359__F6 Concerted effects of iAs-induced Nrf2 and HIF1A on glycolytic metabolism CTRL HEL107 PGAM1 ENO3 HEL-S-68p PFKP HK2 HEL-S-162eP ENO1 HIF1A HEL-S-87p HEL-S-30 PMC9144327__F3 Diffuse Intrinsic Pontine Glioma: Molecular Landscape, Evolving Treatment Strategies and Emerging Clinical Trials ACVR1 EZH2 KIP75 PMC6862519__F3 Schematic model CASR AQP4 AQP2 AQP3 AVP PMC8080978__F5 Pathways enrichment of Walktrap modules FLT3 STAT2 EPO PTPN11 TRAF3 RHO GRB2 MTOR MAP3K14 BIRC2 TRAF2 BIRC3 PMC8080978__F3 GO and Pathway enrichments of the PPI network FAT4 HHIP TNFAIP3 MAFG CREB5 AK3 RCOR1 PTEN MYC CD151 APP DMD H3C8 CEBPB BIRC3 LTBP2 ANKRD1 ERBB4 SPRY4 CRKL RGMB PTGS2 VEGFA IL1A IL6 TNF GNA14 CBL H3F3B DGKD MAP3K7 CPQ CALCA FLRT2 CLDN1 GNA13 EHD1 PMC10379484__F2 Endothelin-1 in Health and Disease VWF LAMP2 CD81 EDN1 PMC8080978__F9 Hypothesized mechanism of action of downregulated ERBB4 in SARS-CoV-2 infected cells TMPRSS2 ERBB4 EGFR APC PMC5880643__F1 Peripheral complement interactions with amyloid B peptide (AB) in Alzheimer’s disease: 1. Erythrocyte clearance of AB HEL-S-62p C1S C4A C4B_2 PMC8034193__F4 Calcium (or Ca2+) signaling pathway in T SLC25A4 TRDN PLN CCKBR CAV2 HRC BCR PI3 CALM1 MCU PMC9674149__F7 Kyoto encyclopedia of genes and genomes (KEGG) signaling pathway map ChAT PMC8081888__F4 Metabolic Landscape for Maintaining Retina Integrity and Function RPE MAL LDHB PMC4061475__F1 Dopamine biosynthetic pathway TH PAH PMC3770583__F7 Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice CDC42 BAD PAK1 CCND1 PMC5416929__F8 Working model of TGFB and NFKB pathway interactions that regulate GCT viability SMAD2 PMC4132962__F1 Protective mucosal immunity mediated by epithelial CD1d and IL-10 STAT3 APC PMC4001311__F6 Schematics of the regulation of the HMOX1 expression under normal (a and b) and stress conditions (c and d) and without (a and c) or with (b and d) BRD4 knockdown BRD4 SP1 KEAP1 MX1 PMC10539950__F2 Innate immune signalling in response to cytosolic DNA and DNA damage TBK1 CGAS RELB ATM IFI16 IRF3 CCL5 CXCL10 TRAF6 CCL20 PMC3621569__F6 Planar cell polarity pathway (PCP pathway, non-canonical pathway) cascade CELSR1 ARHA DAAM1 PMC9254110__F7 FOXF2 oppositely regulates stemness in luminal and basal-like breast cancer cells through the Wnt/beta-catenin pathway TF HDAC3 BCR NCOR1 FOXF2 FZD1 PMC3010226__F2 Cellular and molecular scheme for an adaptive immune axis leading to acute lung disease after viral infection TH CCL19 FCER1A CCR5 PDC CCR7 AHR CCR10 PMC5507681__F8 Signaling pathways involved in keratinocyte growth and differentiation that are perturbed by SbIII and AsIII KRT1 LRIG1 EGF FOXN1 EGFR NOTCH1 PMC9664671__F1 HOXA9 in solid tumors: mechanistic insights and therapeutic potential JUN HK2 ULK1 SOX2 MTOR RUNX2 FOS IRS1 CTNNB1 ATG12 HOXA9 BCL2 CYBB PMC7960940__F7 IPA network analysis of differentially expressed proteins in G6PC3 deficiencyIngenuity Pathway Analysis (IPA)-based network 1 of the 148 differentially expressed protein panel IL13 C1QB GPX3 PTGS2 FOS GATA3 IL-21 TFPI2 ENG IGLL5 DGKA C2 PLCB1 TNFSF11 GATA4 BCL6 CD3E PMC7960940__F8 IPA networks analysis of differentially expressed proteins in G6PC3 deficiencyIngenuity Pathway Analysis (IPA)-based network 2 of the 148 differentially expressed protein panel SAA1 CD40 VWF JUND F5 CCL3 TNFSF8 IL13 MCL1 IRF7 IL6 SATB1 TAF8 GP1BA AGER F2 F8 F9 HBB S100B PMC6482478__F1 Basic mechanisms of lithium function IPP GSK3B CHN1 PMC7171331__F7 LGR6 KEGG pathway SOST INVS SIAH1 STOM APC NOTUM SMAD4 SKP1 RYK ARHA NLK DAAM1 PMC5008685__F2 Mechanisms of initiation of translation ELF1 SUI1 EIF5 ATF4 EIF2A ELF5 ELF3 PMC5008685__F1 PERK-dependent Unfolded Protein Response ATF4 EIF2A CCND1 PMC12081606__F7 Working model BNIP3L FUNDC1 NRF1 PMC5008685__F4 CHOP-induced apoptosis under prolonged ER stress DDIT3 ATF4 ERO1A EIF2A PMC6008457__F1 Reaction scheme of the metabolic sub-model LPA GAL LOX GRAP MAL GIP INS PMC5866223__F3 Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension KY RHO PMC6406535__F1 Contrasting Patterns of Rapid Molecular Evolution within the p53 Network across Mammal and Sauropsid Lineages PPM1D ATR FAS SFN PTEN MAPK14 MDM4 GTSE1 CCNG1 CCNE1 CCND2 CHEK2 ATM MDM2 CCND1 SIRT6 BAX CASP9 CASP8 SIAH1 PERP ZMAT3 TSC2 IGF1 CDKN1A STEAP3 SESN3 CASP3 CHEK1 RCHY1 PMC6083633__F2 Molecular mechanism model for lncRNAs involved in the tumorigenesis of human TNBC BLK EGF HBEGF LRRK2 EGFR ARF6 GPNMB IGF2 PMC6261981__F2 Potential mechanisms involved in propagation of Alpha-syn IFNG TH NLRP3 RNF11 MTOR MPO PMC9633631__F3 Lung fibrosis: Post-COVID-19 complications and evidences TF MMP7 MMP14 APC CTNNB1 PMC6103439__F5 Homeostasis, regeneration and tumour formation in the mammalian epidermis GSK3B MMP2 IL6 CTNNB1 PMC9633631__F4 Lung fibrosis: Post-COVID-19 complications and evidences LATS1 BIRC5 LATS2 AXL AREG PMC5069085__F1 Integration of lipid homeostasis into the macrophage host defense response TLR4 MARCO IL1B PMC11502746__F6 Selected impacts of MGO exposure in SH-SY5Y cells ATP5F1D HMOX1 ENO2 UQCRB IDH3B KEAP1 GCLM NDUFB4 NDUFA7 COQ6 PFKL NDUFS4 PMC3416758__F7 TAp73-Mediated the Activation of C-Jun N-Terminal Kinase Enhances Cellular Chemosensitivity to Cisplatin in Ovarian Cancer Cells BAX ATF2 FOS PMC3148248__F5 TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding HMGB1 TIRAP TLR4 CD14 IRF3 RAC1 LBP IRAK4 MYD88 PMC8495178__F8 N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells METTL4 PMC6489264__F1 Dauer signalling pathway model proposed for Haemonchus contortus NCR1 NCR2 SGK1 PPM2C INS PMC1839891__F1 Systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery SMO PMC2776723__F6 Integration of activated transcription factors with the upstream signaling network during CB1R-induced neurite outgrowth NR1i1 STAT3 MYB HIVEP1 PAX6 RUNX2 THRA POR STAT1 CEBPA NFYA STAT4 SRC CREB1 PMC7588666__F1 Base excision repair and its implications to cancer therapy OGG1 PNKP LIG1 FEN1 PCNA PARG NEIL1 UNG PMC3769628__F2 Four current models of PARP inhibitor-induced cancer cell killing RAD51 BRCA1 BRCA2 ATM PTEN PMC9569475__F5 Hsp90 as a Myokine: Its Association with Systemic Inflammation after Exercise Interventions in Patients with Myositis and Healthy Subjects STAT3 STAT1 PMC3621569__F3 Inversin functions as a switch between the canonical Wnt and non-canonical Wnt/PCP pathways APC GSK3B LRP5 LRP6 ARHA CTNNB1 PMC7795665__F3 PPARG involved in trophoblast differentiation GCM1 CTNNB1 PMC5086000__F1 Inflammasome Activation Mechanisms during Bacterial Sexually Transmitted Infections (STIs) NLRP3 AIM2 NOD1 IL1B MYD88 PMC9261390__F1 Implications of Sphingolipids on Aging and Age-Related Diseases CERS3 CERS5 SPHK2 tmp_locus_29 CERS1 CERS2 SPHK1 CERS6 PMC8080836__F3 GD T cells ZAP70 IFNG STAT3 SOX13 CD27 IL18 BTLA CTLA4 IL1B PMC12154794__F3 Retinoids and fibrosis TGFB1 EPHA2 SMAD2 PMC9253924__F45 Inhibition of anti-inflammatory pathway through suppressors of cytokine signalling (Socs2/Socs3) in the initiation of hepatocellular carcinoma KRT18 CYP1A2 CYP2E1 SOCS2 SOCS3 CYP1A1 MYD88 PMC7521313__F7 Mechanism of danshen on heart failure is mediated by MyD88‐dependent TLR4‐TRAF6‐NF‐KB inflammation pathway’ TLR4 RELA TRAF6 PMC10242999__F2 Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer CDC42 TF SRC PMC3849481__F6 Schematic diagram showing CSFV triggers RIG-I and MDA5 dependent signaling pathway to IRF-3 and NFKB activation to promote the production of antiviral and inflammatory cytokines in porcine alveolar macrophages CSA2 TBK1 IRF3 IL1B PMC4278548__F1 Central metabolic routes and the aromatic compounds biosynthesis showing key metabolites and the genes involved in their transformation AAMP MAL PPY CIT PMC10242999__F3 Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer TF EGF F3 PTEN MTOR KRAS TNF RAC1 CTNNB1 PMC5466514__F1 Cancer cells take advantage and manipulate the ROS-Ca2+ interplay in two ways: 1) by inhibiting large ROS-Ca2+ surges that mediate apoptosis (red pathway) ORAI3 TRPM2 ORAI1 STIM1 TRPC1 TRPV1 MCU TRPC6 PMC5510801__F1 Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model DKK1 APC SFRP1 CTNNB1 PMC7521313__F3 Danshen is shown to regulate the TLR signalling pathway CSA2 CD80 TIRAP MAPK13 FRK PIK3CD CTSK TLR9 CD14 IL4 IL6 CXCL10 RAC1 SPP1 TLR4 TLR8 MAPK10 LBP FADD PMC4085163__F6 Schematic models of signalling pathways used by SDF-1/CXCR4 and GLP-1/GLP-1R in the activation of beta catenin/TCF7L2-mediated transcriptional expression of genes involved in beta cell survival and proliferation a SDF-1 activation of WNT signalling TCF7L2 APC CXCR4 PMC7467536__F2 PRC2-mediated feed-forward control of transcription factors and signaling pathway components can serve as a “dimmer switch” of gene expression changes TF COMP PROZ PMC9600545__F4 Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance IFNG STAT1 IFNGR1 IL4 PMC12235416__F1 (Figure created using BioRender MAML1 ADAM17 ADAM10 PMC5352108__F1 Long non-coding RNAs in anti-cancer drug resistance PTEN CTNNB1 PMC7000272__F1 RELA interactome CASP8 NFKB2 RELB HIF1A SQSTM1 VEGFA PLK1 CXCL8 CTNNB1 SOX9 NFKB1 FOXO3A RELA NOD2 BCL2 NOTCH3 TWIST1 CYLD ELF3 PMC8834144__F8 Comparative Transcriptomic Profiles of Differentiated Adipocytes Provide Insights into Adipogenesis Mechanisms of Subcutaneous and Intramuscular Fat Tissues in Pigs MTHFD2 FAS PLK2 CA13 DGKD CYCS THBS3 GALNT6 PFKL FOS PMC7072933__F1 Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma RHEB TSC2 TSC1 MTOR PMC9485270__F5 Melanoma: Molecular genetics, metastasis, targeted therapies, immunotherapies, and therapeutic resistance CDKN2A BRAF NRAS TERT PTEN MYC NEDD9 CTNNB1 PMC11084446__F8 Brief diagram of the proposed therapeutic effect of the LiESWT in improving detrusor hyperactivity via TRPV channels and the cellular signaling pathway involved in regulating intracellular Ca2+ oscillation in a rat model of OHD-induced DHIC TRPV1 ARHA PMC5055575__F9 The signalling pathways mediating PTH and BMP-2 induced regulation of Phospho1, Smpd3 and Alpl in osteoblast cells ALPI ALPL BMPR1A BMP2 PTH PTH1R PHOSPHO1 PMC8631470__F1 Cross-Talk Between Tumor Cells Undergoing Epithelial to Mesenchymal Transition and Natural Killer Cells in Tumor Microenvironment in Colorectal Cancer BAX HMGB1 TIGIT CRTAM CADM1 ADAM17 PCNA MICA MICB PMC5833552__F1 Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation CD40 CD80 BCR TLR4 TLR9 IL1B PMC7467536__F1 PRC2 core and accessory proteins and downstream effects ME3 EPOP AEBP2 ME2 ME1 PMC3218884__F4 Signalling network of proteins identified as major targets of autoantibodies in patients with unidentified ANA PROX2 HNRNPL RB1 FUS DEK HEL-S-99n HEL113 RBBP4 KHSRP HDAC2 LMNA PMC11772333__F5 Biosynthetic pathway of three representative pyrroles POR PIGC CPO UROD MGMT UROS PMC4512304__F2 Ramification of IFN signaling pathways leading to immunostimulatory and immunosuppressive regulation of macrophage polarization CXCL9 IFNAR2 IRF9 IFNAR1 IRF1 MX1 JAK1 TYK2 PMC7374916__F10 Schematic illustration of the proposed mechanism for H2R/H3R to alleviate microglia-induced neuroinflammation FOXO1 TLR4 IL1B PMC5527800__F3 Ingenuity pathway analysis ST14 CD40 KLF2 JUND MMP14 TGFBI TIMP1 TGFB1 HGF LEP OSM THY1 FCER2 NR0B2 MYC CTSG MAPK3 MMP11 CTNNB1 NNMT EIF2S1 PLAT MME INHBA ADAM17 SP3 MMP2 MMP3 A4GALT MAPK1 DAG1 GAL SELL JUNB PLAUR IGF2 FOS IRS1 ACAN HRAS CD44 TG LOXL2 EDNRA LCN2 PMC6534900__F3 Summary of the regulation network of Ids in heart development is shown MESP1 SMAD1 DKFZp781O1323 WNT3A BMPR1A SMAD4 TBX5 ISL1 ACVR1B SMARCD3 FOXA2 KDR GATA4 PMC11647257__SF2 Various signaling molecules, such as glucocorticoids, androgens, progesterone, BMP4 (which activates SMAD), and IL-6 (which activates the downstream signaling molecule STAT3), regulate the transcriptional activity of S100P in cancer cells STAT3 BMP4 CACYBP S100P PMC5062963__F7 Comparative model of transcriptional activation of ERA by cognate ligand versus cAMP signaling in the absence of estrogen HDAC1 REST CARM1 GRIP1 HDAC6 PMC4254647__F3 FA/BRCA DNA damage response pathway BRIP1 RAD51C USP1 BRCA2 PALB2 UBE2T PMC6994583__F1 Pathways of H2S production VIT PMC8065809__F10 Postulated model for the mechanism underlying IGF-Trap resistance in MDA-MB-231 FRS2 FGFR1 GRB2 PMC9458025__F3 Functional Annotation of Lactiplantibacillus plantarum 13-3 as a Potential Starter Probiotic Involved in the Food Safety of Fermented Products ALB ENG XK WAS BOK SHE PMC2872188__F2 Generalized depiction of the energy cost of neurovascular coupling and its impact on astrocytic glucose utilization (CMRglc) C2 PLAA PMC3305403__F4 The Nucleoside Diphosphate Kinase Gene Nme3 Acts as Quantitative Trait Locus Promoting Non-Mendelian Inheritance NME3 FGD2 RHO PMC6631168__F1 The Role of Wnt and R-spondin in the Stomach During Health and Disease RNF43 SOX9 APC SOX2 GSK3B LRP5 ZNRF3 LRP6 GPR49 LGR6 PMC9205222__F2 Molecular Approaches Reduce Saturates and Eliminate trans Fats in Food Oils LPA FAS HEL-S-5 PMC8529064__F5 Microbiota in Infant Health: From Early Life to Adulthood HBD TIFA TRAF6 PMC2750148__F2 NFKB signal transduction UBC TRAF6 MYD88 PMC4959106__F1 De novo SL biosynthesis and S1P metabolism S1PR1 SPNS2 SPHK2 tmp_locus_29 SPHK1 PMC5466881__F1 Strategies for Increasing Pancreatic Tumor Immunogenicity CD40 CXCL13 GEM CCL2 PMC11177172__F5 Regulatory associations between protein-protein networks, based on the IPA Knowledge Base RPS15 RPS15A HMGB1 PCBD1 TARDBP EIF1AX SRP9 RPS10 FABP5 TRIM25 RPS12 RPS9 AHNAK CP PMC4959106__F3 Nogo-B regulates de novo SL biosynthesis through the inhibition of SPT activity to control vascular tone and BP S1PR1 SPNS2 NONO S1PR2 ARHA PMC8533259__F3 Coordination of RNA Processing Regulation by Signal Transduction Pathways ATR MDM2 PMC7346062__F5 KEGG pathways related to resveratrol-targeted genes AKT3 TP63 MDM2 PMC4401777__F7 Loregic: A Method to Characterize the Cooperative Logic of Regulatory Factors GATA2 HEL-S-76p NFE2 EGR1 tal-1 SP1 NFYA GRN HDAC2 PMC8154354__F2 Insights into Ammonia Adaptation and Methanogenic Precursor Oxidation by Genome-Centric Analysis POR AMT MTR PMC2246131__F7 Schematic diagram showing the possible effects of the reelin pathway in protection from CM DAB1 VLDLR GSK3B SRC RELN PMC5988607__F1 Signaling network of MST1 and MST2 kinase LATS1 MOB1A MOBKL1A LATS2 FOXO3A PMC5727869__F10 The function mechanism of HER2-HER3 co-expression STAT3 MTOR PMC9033932__F3 Targeting TGFB signal transduction for fibrosis and cancer therapy SPSB1 SMAD4 PMC4214731__F8 Network-Based Classification Model for Deriving Novel Drug-Disease Associations and Assessing Their Molecular Actions STAT3 PPARG PLCG1 SOS1 FOXO1 MTG1 AGTR1 PTPN11 A2M IL2 GRB2 CREB1 PMC4909545__F1 Nutrient-sensing mTORC1: integration of metabolic and autophagic signals ATG101 RHEB TSC2 TSC1 TFEB AMBRA1 TTI1 DAPK2 DEPTOR PMC11803499__F2 B cell signaling is integrated downstream of activating receptors to regulated B cell‐specific cellular functions and B cell fate decisions CD40 SYK CD79B CD79A RELB TLR9 CD19 MTOR TRAF3 TRAF6 DEPTOR EIF4E MYD88 RHEB TSC2 BTK RICTOR TSC1 BCR RELA TLR7 LYN TRAF2 PMC5024535__F6 Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression NTS CDA DTYMK DPYS DCTPP1 DPYD TYMS TYMP PMC10707303__F5 Fibrotic factors in the development of DKD STAT1 WT1 MMP2 PMC11803499__F4 Inhibitory receptors modulate the PI3K/AKT/mTOR pathway to influence B cell fate decisions RHEB CD40 TSC2 FAS RICTOR TSC1 BCR CD22 PTEN DEPTOR PMC4640679__F5 Non-biased molecular screening identifies novel molecular regulators of fibrogenic and proliferative signaling in myxomatous mitral valve disease MMP16 JUN SIK1 HGF CD69 CD14 TCF4 FCGR1A RUNX2 MYC FOS CD83 FZD8 TLR3 CX3CR1 CD93 CX3CL1 BMP4 FGF9 TOB2 MMP2 IL7 TLR7 WNT9A PMC4633932__F2 Nutrient, growth factor, and energy sensing impinge on the mTOR pathway RHEB RICTOR MTOR PMC5512170__F3 Barcoding of GPCR Trafficking and Signaling Through the Various Trafficking Roadmaps by Compartmentalized Signaling Networks VPS29 VPS35 FKBP15 SNX27 PMC2975092__F6 Biological interaction between glucose and genes up- (light grey) or down-regulated (white) in primary hepatic stellate cells after overexpression of Smad7 LPL HEL-S-101 HGF ENO2 CYP2E1 EIF4EBP1 HK2 VEGFA NR2F1 EPHX1 PFKP HEL-S-14 AKAP12 PMC6441107__F7 Proposed diagram for miRs-449 regulation in doxorubicin sensitivity and resistance cells RB1 CCNE2 CDK6 CDK2 CDK4 PMC7334005__F6 Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space HDAC3 OGT PER2 NCOR1 CRY1 ALAS1 NAMPT HDAC2 SIRT1 PMC11663674__F1 Isolation, bioactivity, and synthesis of natural products from Litsea verticillate with anti-HIV activities TES PDC CUTC MB ME1 PPY PMC6796923__F4 LSECtin-BTN3A3 axis promotes breast cancer stemness in vitro SOX2 BTN3A3 PMC4809656__F8 Molecular mechanisms by corilagin suppresses cholangiocarcinoma progression through Notch signaling pathway MAML1 MTOR HES1 NOTCH1 PMC8901598__F2 Metabolic and Epigenetic Regulation by Estrogen in Adipocytes ADRB3 TET2 PPARG EBP UCP1 EZH2 KDM4B ERG TDG PMC2637898__F2 EGFR signaling pathways TSC2 PTEN GRB2 MTOR PMC2637898__F3 EGFR signal transduction pathways EGF HBEGF TGFA EGFR PMC2637898__F4 VEGF signaling pathways VEGFC NRP1 NRP2 PMC6829200__F1 Components and regulatory factors in the complement alternative pathway (CAP) HEL-S-62p CFI CFH CS PMC4663505__F7 Drug target prioritization by perturbed gene expression and network information KLF4 BAX PPARG JUN LYPD3 RHOF ADM EGFR PTEN PTGS2 TNF MYC TFF2 WT1 NFKB1 RHOB JAG2 ADFP WNT4 PTGES CREB1 SPRY1 PMC5298971__F1 Vitamin D synthesis pathway VIT NR1i1 CYP2R1 CYP27B1 CYP24A1 CYP27A1 PMC3772119__F1 Drosophila JAK-STAT pathway in blood cell formation and immunity GAA LAT BCL6 PMC2763507__F1 Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses JUND BAD MARCKS BDNF CTNNB1 PMC4344844__F2 Wnt and FGF mediated epithelial mesenchymal crosstalk during lung development PTEN GRB2 MTOR CTNNB1 PMC6759464__F1 Abbreviated summary of monocyte activation pathways CRP CCL18 IL16 TLR4 LBP PMC8996539__F4 Neutrophil degranulation and myocardial infarction MMP7 CD36 PLG MMP2 MMP3 MMP9 PMC7564943__F6 AhR-induced cyclooxygenase (COX) 2/PGE2/EP4 has differential effects in anti-viral cells vs COX2 PDC AHR PMC11079401__F2 MiRNAs in EMT regulation via TGFB signaling pathway in pancreatic tumor cells RAF1 SMAD2 NRP1 SMAD4 ARHA SMURF2 DUSP2 PMC11079401__F3 MiRNAs in EMT regulation via PI3K/AKT signaling pathway in pancreatic tumor cells ANXA3 KDM5B MTOR S100P PMC7564943__F3 AhR activation contributes to alterations in mitochondrial metabolism as does suppressed pineal melatonin COX2 PDC AANAT AHR ASMT PMC10670414__F8 Anticancer Effects of 6-Gingerol through Downregulating Iron Transport and PD-L1 Expression in Non-Small Cell Lung Cancer Cells BAX STAT5B STEAP3 EGFR PMC11079401__F4 MiRNAs in EMT regulation via WNT and JAK/STAT signaling pathways in pancreatic tumor cells APC SOCS5 LRP5 LRP6 SOCS3 ST7L CTNNB1 PMC8841354__F5 Interleukins and Ischemic Stroke IL19 IL33 IL18 IL1B PMC6066316__F8 Differentiation of monocytes promotes resistance to ripoptosome signaling RIPK3 MLKL TLR4 IFNAR1 RIPK1 PMC8001593__F3 Host-catalyzed HIV-1 assembly pathway was developed into a screen for small molecule inhibitors XRN1 PMC5683051__F1 Interconnection between endoplasmic reticulum (ER) stress/unfolded protein response (UPR) pathways and mitochondria-NLRP3 inflammasome in allergic diseases NLRP3 ATF4 EIF2A ATP6 IL1B PMC8431527__F1 Hypoxia Pathway Proteins and Their Impact on the Blood Vasculature STAT3 ING4 LIMD1 ARG1 VHL RUNX3 PMC4344844__F3 Wnt and FGF mediated epithelial mesenchymal crosstalk during lung development APC LRP5 LRP6 CTNNB1 PMC11900433__F9 Phosphoinositide 3-kinase (PI3K)/Akt pathway PTEN MTOR PMC11904867__F2 Nur77 in glucose metabolism PGAM2 ENO3 FBP1 PIR ENO1 MTOR HEL-S-30 PMC9515456__F4 Sneaking into the viral safe-houses: Implications of host components in regulating integrity and dynamics of rotaviral replication factories AGO2 EDC4 DCP1A EIF2A XBP1 DCP1B PMC11900433__F8 MAPK/AP-1 signaling pathway MAPKAPK2 MAPKAPK3 MAPKAPK5 RAC1 PMC7940537__F1 MTORC1 signaling and glycolysis pathways MTOR DEPTOR EIF4E PMC11900433__F5 NRF2–ARE pathway RBX1 KEAP1 PMC5009750__F1 NFKB pathway genes with correlation to HOXA1 expression in breast cancer CD40 ZAP70 SYK CXCL12 LTA LTBR TRADD TIRAP LAT NFKB2 TRAF3 TRAF6 PRKCB NGF LY96 PLCG1 BCR ATM CD14 BLNK CXCL2 CD40LG PTGS2 TNF LTB TNFSF14 CNTF TRIM25 NFKB1 BCL2 TNFSF11 LYN LBP TRAF2 LCK PMC6531411__F1 Diversity of the effects of DJ-1 in cell TH BAX CMA1 KEAP1 TOPORS PTEN DDC PMC5384354__F9 Proliferation by crosstalk of miR-204 and miR-17/92 in smooth muscle cells STAT3 PAH SRC PMC7481292__F5 Summary of effects of TCDD on OCM gene expression and metabolites HEL-S-182mP HEL-S-61p PMC8430083__F5 Comprehensive network analysis of different subtypes of molecular disorders in lung cancer TNC COMP BTK COL1A1 RECK AGER SOCS3 CCL2 SKP2 ITGAV MPO PMC4593320__F2 Role of Bmi-1 in Ink4a/Arf Pathway PRC1 MDM2 CDK4 PMC8066025__F2 Indirect antiviral activities of PARPs through immunomodulation PARP10 IFNG PARP12 PARP11 PARP14 TANK DTX3L IRF3 PMC10310985__F4 DEAD-box RNA helicases with special reference to p68: Unwinding their biology, versatility, and therapeutic opportunity in cancer STAT3 EGFR APC PTEN GRB2 MTOR TRAF2 PMC6503977__F7 Proposed Shh-Foxd1-Cdkn1c signaling model FOXD1 PTCH1 SHH CDKN1C SMO CCND1 CDK4 PMC6892507__F5 Gene expression is associated with virulence in murine macrophages infected with Leptospira spp ATM PMC2871799__F6 Human endometrial receptivity SERPINF2 HEL-S-62p PLG HEL-S-78p JAM3 TGFBR1 MASP1 BMP6 C2 FST F2 PROS1 MB PROC DCN BDKRB2 PMC11937194__F5 Related mechanisms of TRPC1, TRPM7, CLCA2, CLCA4, and TTYH3 in the process of EMT CDH2 CLCA4 TRPM7 RAF1 TRPC1 TTYH3 PMC11937194__F6 Related mechanisms of TRPV1, TRPM8, Orai1and KCa3 ORAI1 CD69 TRPV1 TNF TRPM8 PMC11937194__F7 Related mechanisms of TRPC3, TRPV1, L-VGCC, A2D1 and TTYH3 in regulating tumor stemness HRAS TRPV1 MMP2 CCND1 TRPC3 TTYH3 PMC8170311__F1 Metabolism in the Development of Personalized Therapies in Acute Myeloid Leukemia FLT3 CD36 NPM1 EZH2 SLC7A5 PMC11937194__F4 Related mechanisms of TRPV3, TRPV4, and Orai1 in tumor angiogenesis ORAI1 TRPV3 PMC9457814__F2 Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches TF MTOR PMC8172474__F1 Therapeutic Escape in GAq-Mutant Uveal Melanoma: It’s a FAK TRIO BAP1 RHO LAG3 PMC7585948__F10 Targeting feed-forward signaling of TGFB/NOX4/DHFR/eNOS uncoupling/TGFB axis with anti-TGFB and folic acid attenuates formation of aortic aneurysms TGFBR2 DHFR NOX4 TGFBR1 PMC3882126__F1 Autism genes keep turning up chromatin SHANK3 SMARCC1 SMARCC2 JMJD1C ARID1B CHD8 GABRB3 SMC1A MTOR NLGN3 NRXN1 PMC5359687__F1 Heterogeneity in Cancer Metabolism: New Concepts in an Old Field GLUD1 HEL107 GLS HEL-S-133P FASN PSAT1 ME1 PMC8524664__F10 Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3B signaling pathway BAX GSK3B PMC5359687__F6 Heterogeneity in Cancer Metabolism: New Concepts in an Old Field CXCL12 FOXP3 MTOR PMC10380285__F1 Influence of Single Nucleotide Polymorphisms on Vitamin D Receptor Protein Levels and Function in Chronic Liver Disease NR1i1 SP1 SP3 SRC PMC8727779__F3 Strategies to overcome drug resistance using SHP2 inhibitors EGF CSK GRB2 SRC PMC3939323__F3 A, JAK-STAT signaling pathway in interaction network CBL PIM1 EPO IL6 PMC9377404__F8 Vitamin B6 Metabolic Pathway is Involved in the Pathogenesis of Liver Diseases via Multi-Omics Analysis GUSB DCXR AOX1 HEL-S-302 SORD AKR1B10 DAO POR HEL30 C2 UGDH IL18 PSAT1 HEL-S-165mP XYLB PMC8196896__F3 Transmembrane TNF and Its Receptors TNFR1 and TNFR2 in Mycobacterial Infections TRAF1 TNF TRAF2 PMC8196896__F2 Transmembrane TNF and Its Receptors TNFR1 and TNFR2 in Mycobacterial Infections RIPK3 TRADD RIPK1 SMURF2 TNF TRAF2 FADD PMC8923098__F1 Reversing epigenetic repression of transposable elements for improving tumor immunogenicity TES CGAS MAVS SETDB1 PMC5189614__F1 Cellular control of hyperglycemia EGF EGFR IGF1R GRB2 MTOR PMC4701041__F7 Proposed model for a critical role of ERA in E2-induced cholesterol gallstones ABCG5 ABCB11 ABCB4 LDLR PMC3434475__F1 The canonical translation pathway in eukaryotes with the ribosomal recycling and initiation phases shown in detail ABCE1 EIF4B ELF1 SUI1 ELF2 EIF5 ELF5 ELF3 PMC10993426__F2 Metabolites, metabolic pathways and related metabolic genes that take part in necrosis and necroptosis ZBP1 MLKL ATF4 STRAP PMC2930269__F2 CSCs drug resistance methodology ABCG2 CD47 ABCB1 MGMT PMC10993426__F3 Metabolites, metabolic pathways and related metabolic genes that play the roles in ferroptosis TF GPX4 BAP1 SLC7A11 HEL-75 PMC7520711__F1 Major regulators and effectors of the phosphatidylinositol 3-kinase (PI3K) pathway in lymphocytes PIK3IP1 BCR INPP4B PI3 CD19 PTEN MTOR PMC10993426__F1 Metabolites, metabolic pathways and related metabolic genes that play the roles in apoptosis ACLY BAX TRADD SCD ETV4 NAMPT TIGAR MTOR APAF1 FADD PMC10993426__F7 Metabolites, metabolic pathways and related metabolic genes that work in autophagy STK11 HEL-S-162eP SIRT1 PMC10993426__F4 Metabolites, metabolic pathways and related metabolic genes that play the roles in pyroptosis GSDMD NLRP3 GPX4 IL18 LDLR FABP4 PMC11647257__SF6 CNN1 signaling pathway involved in cancer DKK1 HEL-S-14 MMP2 MMP9 MTOR CTNNB1 PMC8236857__F2 Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead MAX MIA PTCH1 MYC PMC8236857__F3 Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead EPHA2 HMGCR FASN IL13RA2 PMC4509978__F2 CMV-induced embryonic mouse organ of Corti dysplasia: network architecture of dysfunctional lateral inhibition PROX1 HEY2 PCNA ATOH1 JAG2 FGFR3 NOTCH1 FGF8 HES5 PMC10875085__F2 Mechanisms for E protein-induced lung injury NLRP3 PALS1 IL6 MYD88 PMC11725633__F2 Immunoregulation of CD4+ and CD8+ T cells by fatty acids ACLY CD5L FASN PCYT2 FOXP3 GATA3 PMC5898978__F1 Prostaglandin E2 as a Regulator of Immunity to Pathogens LTB LTA PMC11725633__F1 Fatty acid metabolism in T cells LPA FFAR3 CD36 FASN FFAR2 FFAR1 PMC7775286__F1 Diagram of NK cell receptor signaling: KIR2DL4 ZAP70 SYK FYN LAT VAV1 PMC7157668__F1 Mycobacterium evades macrophage apoptosis by induction of anti-apoptotic cytokines and miRNAs expression TRAF4 STAT3 BAX BAD FAS EBI3 BCL2 NOP53 TYK2 FADD PMC7734804__F1 Initial establishment of anti-viral state via innate immune responses to DENV infection TBK1 CGAS MAVS IRF3 IRF7 TRAF3 TRAF6 MYD88 PMC10452836__F7 Reconstructed network using StringDB of the dynamic interactome of KRASG12C (grey halo) in HEK293 cells identified in the AP-MS screen JUP WTIP KRAS RADIL PMC10875085__F1 Mechanisms for S protein-induced lung injury STAT3 NLRP3 TLR4 IL6 ACE2 PMC3703753__F2 Impact of Subarachnoid Hemorrhage on Parenchymal Arteriolar Function HBEGF KY EGFR PMC10879484__F7 Predicted activation of macrophage classical activation signaling pathway in parenteral nutrition piglets PARP14 CD14 IRF1 HEL-S-30 TNF MERTK IFNG TLR4 RELA NDUFS1 CCL20 GBP2 CYBB PMC10879484__F8 Therapeutics identified as strongly inhibited upstream regulators in Ingenuity Pathway Analysis NR1H4 JUN STAT2 IRF9 CREBBP MED1 FOS PMC3083951__F3 A model (steps 1-4) for copper homeostasis in Schizosaccharomyces pombe (Schiz SCO1 COX17 COX11 PMC4550399__F8 Temporal Gene Expression of the Cyanobacterium Arthrospira in Response to Gamma Rays C6 CUTA PMC5045492__F2 Depiction of the organization of the major steroid biosynthetic pathways in the adrenal cortex POR STAR SULT2A1 CPD PMC5012644__F2 Hypoxia-inducible transcription factor (HIF) pathway in clear cell renal cancer PBRM1 BAP1 SETD2 ELOC VHL PMC2646147__F6 A model for three pathways of TLS in mammalian cells POLK POLN CPD PMC7103649__F9 Significant correlations between HSD17B4, ACAA1, and PXMP4 expressions and immunomodulator gene expressions CD40 HSD17B4 TAPBP CXCL12 LTA TGFB1 PDCD1 CD27 TNLG8A CD180 IL2RA TNFRSF25 PXMP4 HAVCR2 TNFRSF18 HLA-E CDA KLRC1 HLA-F TNFRSF17 KDR MICB TAP2 HLA-DMB IL10 CD2 TNLG2A TNFRSF14 TNLG1B KIR2DL1 TNFRSF4 TNFRSF9 TNFSF13 TMIGD2 HHLA2 KLRK1 ULBP1 B2M CTLA4 LGALS9 TNFSF14 TIGIT IDO1 CD160 BTLA HLA-B CXCR4 HLA-A PMC4718075__F2 Adipocytokines and Hepatic Fibrosis STAT3 APPL1 SOCS3 PMC6104113__F7 Simplified schematic showing the potential strategy for muscle‐derived miR‐23a/27a to attenuate muscle atrophy and renal fibrosis IGF1 SMAD2 PTEN PMC9588789__F7 Schema depicting the BET inhibitor resistance in PCa cells due to RB loss and hyperphosphorylation BRD4 GNB1L CDK6 CDK4 PMC9576946__F1 Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion CDC2 PIK3IP1 PCNA MCM5 MTOR PMC3297025__F1 IL-1 signaling leads to actin stress fiber formation IRAK1 IRAK2 RHO TRAF6 IRAK4 MYD88 PMC3297025__F2 BTB restructuring and spermiation are coordinated by IL-1A during spermatogenesis IL10 IRAK1 IRAK4 MYD88 PMC9140926__F10 Prunetinoside Inhibits Lipopolysaccharide-Provoked Inflammatory Response via Suppressing NFKB and Activating the JNK-Mediated Signaling Pathway in RAW264.7 Macrophage Cells CSA2 COX2 IL1B PMC9240468__F5 MIR4435-2HG Is a Potential Pan-Cancer Biomarker for Diagnosis and Prognosis LATS1 LATS2 E2F4 SMAD2 APC FZD7 ST8SIA1 YBX1 MDM2 YAP1 CTNNB1 TGFBR1 PMC4012311__F11 Regulation of TRN mechanosensation PI3 PMC5429979__F2 Glutamine/glutamate utilization in proliferating cells SLC3A2 GOT2 GLS SLC25A13 GPT2 SLC7A5 MPC1 ME1 MPC2 GLUD1 PIG59 PDC BCAT2 SLC25A1 HEL-S-32 PSAT1 GPT PMC5429979__F3 Serine/glycine metabolism in proliferating cells MTHFD2 MTHFD1 PHGDH DHFR SHMT1 PSAT1 HEL-S-51e PSPH PMC8264290__F1 Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm JUN HEL-S-62p SELE ITCH MLKL IL13 SOCS3 TRAF3 TNF FOS C2 NOD2 TRAF2 FADD PMC4633493__F1 Mechanisms through which microRNAs (miRNAs) implicated in the TGFB signaling pathway in the lung epithelial cells and fibroblasts STAT3 SMAD2 SMAD4 SMURF2 PMC6581552__F2 Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets FGF8A NR1C1 CYP8B1 FGF21 FGFR4 CYP7B1 CYP27A1 PMC3578987__F2 MITOCHONDRIAL GLUTATHIONE: FEATURES, REGULATION AND ROLE IN DISEASE FAS TNF UROS PMC6886551__F4 Protein–protein interaction network of the differentially expressed proteins between IH-exposed HUVECs treated with or without estradiol (E2) TFB2M TRIAP1 RPS6KA1 NUDT19 COQ9 MTOR TXNL4A NDUFAF4 MEAF6 BRAT1 NOC4L PRPSAP1 LACTB AK1 SAMM50 CSTF1 RPRD1B ATM SH3GL1 ARL1 MRPL47 RPRD2 HDAC2 DAG1 USP34 BRD3 GPT2 PTPN11 WDR26 EHMT1 ASNS RBM28 PMC6002380__F4 NOD-like receptor signaling pathway MAP3K7IP1 TAB3 NOD2 CCL2 TRIP6 CARD9 PMC7582305__F6 Downstream signaling cascade activated by ATR and ATM via CHK1/2 dependent phosphorylation events BAX MDM2 PMC10686798__F1 Wnt/Bcatenin signaling pathway RNF43 APC LRP5 ZNRF3 LRP6 GPR49 CTNNB1 PMC10995981__F2 CircRNAs play a pivotal role in the advancement of esophageal cancer by modulating the Wnt pathway through diverse mechanisms FZD3 ITCH SRXN1 SOX4 CTNNB1 PMC10995981__F3 circRNAs play a pivotal role in the initiation and progression of liver cancer by regulating the Wnt pathway through diverse mechanisms DKK3 HEL-S-68p E2F3 E2F6 APC ZIC1 RTKN2 CTNNB1 PMC6481643__F10 Novel IL-1Beta-ILC3-IL-2 circuit is essential for the maintenance of Tregs and immunologic homeostasis uniquely within the small intestine NOD2 FOXP3 IL1B MYD88 PMC3493339__F4 STRING Network STAT3 UBC TGFA SHC1 NCK1 EGFR PTPN1 PTPN11 PTPN6 STAT1 CBL EREG PLCG1 ERRFI1 ERBB2 GRB2 SRC PMC11798966__F1 Proposed mechanisms of NLRP3 inflammasome activation and regulation in HBV infection GSDMD NLRP3 TLR4 PMC3493339__F1 ERBB Pathway EGF JUN BAD CBL BTC MTOR SHE PMC7349634__F1 Pathways of synthesis of oxylipins from Eicosapentaenoic acid (EPA) and ARA PUFAs TES LOX GLA PMC6168629__F3 Regulatory mechanisms that control the switch from PKM1 to PKM2 RBM4 SFRS3 NEK2 MTOR MYC PMC7593653__F5 Diabetes-induced cardiac UPS dysfunction RFWD2 NR1C1 KEAP1 FOXO1 MAF GATA4 IRS1 PMC7293394__F1 Antibody-mediated complement activation in pathology and protection BCR C2 CR2 CD46 CS CR1 CP PMC4016892__F6 Schematic model illustrating the signaling pathway by which ANG suppresses the inflammatory response involving TBK1-mediated NFKB nuclear translocation in HCFs inflamed by TNFA IL10 IL18 IL4 PMC3246422__F10 PP-associated modulation of inflammatory chemokine production and repair-related processes in keratinocytes through EGFR system IFNG STAT3 TGFA EGFR RHO PMC4088925__F3 Summary of expression patterns of complement components in the placenta CRP CD59 FH HEL-S-62p C9 CR1 CP PMC7601592__F1 Most important approaches to melanoma treatment BRAF KIT PMC8298002__F5 Physiological, Genomic and Transcriptomic Analyses Reveal the Adaptation Mechanisms of Acidiella bohemica to Extreme Acid Mine Drainage Environments FTH1 PMC10375050__F3 Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease TIFA TRAF6 ALPK1 PMC6941427__F4 Differentially expressed genes (DEGs) involved in flavonoid metabolic pathway and lignin metabolic pathway GCG CAD GC PMC8400831__F4 CIDO ontology updates and secondary analysis of host responses to COVID-19 infection based on ImmPort reports and literature TMPRSS2 HP ACE2 PMC6941427__F6 Differentially expressed genes (DEGs) involved in terpenoid metabolic pathway IPP LOX MDC1 MVK PMC3444914__F1 The DNA base excision repair (BER) pathway PCNA POLE PMC6941427__F9 The regulatory network of key long non-coding RNAs (lncRNAs), genes, and metabolites involved in flavonoid metabolic pathway, terpenoid metabolic pathway, and jasmonic acid/methyl jasmonate (JA/MeJA) biosynthesis and signal transduction pathway GCG LOX CAD MVK PMC10375050__F2 Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease NOD2 IRF3 NOD1 TRAF6 PMC6953035__F10 Proposed model depicting the impact of PC1/3 knockdown on the activation of TLR4 STAT3 TLR4 IRF3 MYD88 PMC8883233__F2 MCL1-mediated regulation of apoptosis BAX MCL1 BCL2 PMC5071578__F5 Role of TSN in carcinogenesis HEL-S-43 TGFB1 CXCL16 TSN PMC5038578__F1 Molecular pathways associated with inflammatory bowel disease STAT3 IL10 TNFAIP3 ATG16L1 LRRK2 ARPC2 ITLN1 IRGM DMBT1 XBP1 SLC22A5 TSLP DLG5 NLRP3 TLR4 CCR6 NOD2 PTGER4 IL23R IL18RAP IL12B CARD9 PMC4278335__F4 In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma RNF41 CDC42 EHD2 EHD3 EGF ITCH ERBB4 EGFR ARF6 PTEN MTOR ARHA VPS28 CBL SMURF1 NEDD4 VPS25 LDLR MDM2 CLTC VPS36 PMC9494158__F4 Traditional Chinese medicine prescription Shenling BaiZhu powder to treat ulcerative colitis: Clinical evidence and potential mechanisms STAT3 MAP3K7IP1 TLR4 MYD88 PMC9164031__F6 Inhibition of eNOS Partially Blunts the Beneficial Effects of Nebivolol on Angiotensin II-Induced Signaling in H9c2 Cardiomyoblasts RPS6 MTOR RAC1 PMC6699409__F2 MTORC1 and MEK-ERK signaling pathways regulate eIF4F activity and assembly EIF4B CYFIP1 EIF4E PMC5513767__F1 Complementopathies HEL-S-62p C2 C1S C4B_2 PMC4614807__F2 Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus ATAD2 PRPF19 LIMS1 IRX3 RASSF1 MYH10 HEL-S-77 IRF1 FOXF2 CS PTPRG SUMO1 MAFF SOX9 RBM10 PBR AHR SOX4 PMC5123561__F3 Heterotrimeric G Proteins: Breaking the rules of engagement, space and time STAT3 EGFR SMAD2 MMP9 MTOR PLCG1 CDK5 INSR FOXO1 TLR4 MMP2 BCL2 SRC PMC4614807__F8 Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus STAT1 STAT2 IFNAR2 IRF9 IFIT1 IFNAR1 IFIT3 IFIT2 JAK1 TYK2 PMC6953081__F2 Regulation of eIF4F complex formation by PI3K/Akt/mTOR, MAPK/MNK, and AMPK pathways and drugs targeting these pathways EIF4B EIF4E PMC8014301__F1 The SphK‐S1P‐S1PRs pathway in invasion of the nervous system by SARS‐CoV‐2 infection S1PR1 S1PR3 S1PR2 INA RHO S1PR5 S1PR4 PMC8829062__F1 Deciphering the Roles of Metformin in Alzheimer’s Disease: A Snapshot BACE1 APP MTOR PMC12063284__F3 SMKIs-induced cardiotoxicity STAT3 ATF3 EGFR SLC7A11 SRC PMC8640358__F5 Network Pharmacology and Molecular Docking–Based Investigation: Prunus mume Against Colorectal Cancer via Silencing RelA Expression HEL-S-22 EGF EGFR HIF1A PPP3CA MAPK8 MYC COL3A1 NCF1 PRKCB BIRC5 BCL2L1 CHEK2 PRKCA MMP2 MMP3 CCNB1 CCND1 TOP2A CDC2 CYP1A2 BAX CASP9 PTGER3 GSTM2 CASP8 CXCL2 PTGS2 MMP9 VEGFA IL1A CXCL10 CYP1A1 FOS ERBB3 CDKN1A RELA IKBKB RXRA ADRB2 CASP3 NFKBIA BCL2 ADRB1 CYP3A4 PMC11867957__F1 Classic Wnt/Beta-catenin pathway cascade diagram APC LRP5 LRP6 CTNNB1 PMC8504100__F2 Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives STAT3 TH CCL22 CXCL5 CXCL1 CCR2 CXCL2 MICA FAP CCL5 CXCL6 YAP1 CLCF1 CHI3L1 TSLP DPP4 MSC FOXP3 CXCR4 CD68 CCL17 PMC8504100__F3 Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives STAT3 CCR2 IL6 FAP CTLA4 CCL2 CXCR4 PMC6497965__F6 Proposed signaling cascade for phosphorylated PCNA-promoted EMT PCNA GSK3B ATM PMC7749093__F1 Cardiovascular molecular imaging SSTR2 CCR2 PBR FAP CXCR4 PMC6843074__F4 IL-22 signaling pathway for expression of acute phase response proteins S100A7 IF2B1 CXCL5 S100A8 MMP3 CCL2 S100A9 CDK4 PMC9307950__F4 Sex-biased adaptive immune regulation in cancer development and therapy NR1B3 SHBG TLR4 HSD17B1 TLR9 TLR7 PMC11866596__F1 TREM1 signaling pathway ZAP70 STAT3 SYK TREM1 GRB2 TRAF6 CARD9 MYD88 PMC2106361__F1 Current model of the Fanconi anemia pathway RAD18 ATR PCNA FANCM FANCL FANCA BLM FANCC FANCB FANCE FANCG FANCD2 FANCF BRCA1 FAAP24 PMC6590191__F3 Interaction network formed by the encoded proteins of genes showing P values of potential relevance in our study (P < 1 × 10−4), according to the presence/absence of carotid plaques RPS6KA2 SNX5 ADAM2 LLGL2 TEAD3 PRKCA NOD1 TRAM2 PRICKLE2 KIFC3 Nbla00697 CCDC148 CCDC124 TULP1 MAK KIF17 SYNPR ADAMTS3 ARL5B BAIAP2L2 EPHB1 SPOCK1 GPR158 OVOL2 hEMMPRIN TMEM14B TECTA TMEM132D DSCAM COL25A1 NSUN6 AIG1 GPR132 HEL-177 SH3YL1 FAM135B ECE1 AGBL1 PLA2G6 CATSPERD PMC8260388__F3 Cellular signaling cross-talk between different cardiac cell populations: an insight into the role of exosomes in the heart diseases and therapy SOCS1 TSC1 MTOR ACE2 PMC5339794__F3 Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis CXCL9 RFC1 ABCC1 TGFB1 AMPD1 HLA-DRB1 DHFR SLC46A1 MTRR TYMS HEL-S-70p CXCL10 HLA-DQB1 PTPN22 SLC16A7 TLR4 SLC22A11 ABCC3 GGH ABCG2 ABCC2 CCND1 FPGS ADA PMC3837590__F3 Macrophage infiltration in adipose tissues, oxidative stress and IR LPL CCR2 IL1B PMC3337163__F1 Breaking up is hard to do CDC2 AURKA RALA RALBP1 PMC2774487__F2 Pathway showing genes involved in Parkinson's disease (Courtesy: KEGG pathway) HTRA2 TH CASP9 SNCA PMC6745219__F2 Tumor Necrosis Factor Receptor 1 (TNFR-1) Signalling Pathway BAX TRADD TRAF2 FADD PMC8003366__F1 View at a glance of the landscape of the metabolic interactions between genes and pathways discussed in the manuscript TET2 BAX HEL-S-26 PMC7117101__F2 Mechanisms by which SND1 promotes oncogenesis SPRY2 TGFBR2 E2F2 ELL CDK2 PTEN CCND1 SND1 PMC4096962__F6 Combinatorial cytokine regulation of iNOS expression in IMF IFNG STAT1 IL1B PMC3515677__F1 Summary of the mechanisms of DC-mediated HIV-1 transmission to CD4+ T cells CCR5 CXCR4 PMC2874080__F2 Pathway of de novo synthesis of saturated and monounsaturated fatty acids and regulation of lipogenic genes by transcription factors (LXR, SREBP-1c and ChREBP) FAS SCD ELOVL6 PMC9054782__F6 Hibiscus sabdariffa extract improves hepatic steatosis, partially through IRS-1/Akt and Nrf2 signaling pathways in rats fed a high fat diet FAS TNF IRS1 PMC3138675__F2 Molecular mechanisms in hereditary cancer APC PTEN MDM2 MTOR CTNNB1 PMC5682923__F1 Complex Roles of mTOR in Adipocytes and Beyond RHEB GRB10 TFEB FLCN PTEN SLC38A9 PMC5772977__F1 The transforming growth factorB1/Smad signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC9137176__F7 Granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin EGFR GC AREG LHCGR YAP1 PMC12072397__F3 The osteoblastogenesis signaling pathway and its lncRNA-induced regulation SMAD4 MYC PSEN1 BAMBI CTNND2 FRAT1 SOST CSNK1E DKK1 PRKCA CACYBP NBL1 SOX17 MMP7 SIAH1 ROCK2 ROR2 APC LRP5 LRP6 TUG1 FOSL1 ZNRF3 WNT3 SIRT1 NUMB RYK RUNX2 CTNNB1 NOG ROCK1 DKK2 ROR1 GPC4 JUN ARHA RAC1 ID1 RSPO1 SFRP1 INVS RNF43 CBY1 NOTUM CER1 SKP1 EP300 NLK DLX5 PMC4359241__F2 Androgen receptors beyond prostate cancer: an old marker as a new target CYP1A2 STAT3 CYP2C9 CYP3A4 PMC4359241__F3 Androgen receptors beyond prostate cancer: an old marker as a new target RICTOR MTOR PMC12072397__F2 The osteoclastogenesis signaling pathway and its lncRNA-induced regulation SOCS1 SYK STAT2 OSCAR CTSK MAFB BLNK NFATC1 ARHA IRF8 TUG1 TRAF6 TREM2 STAT1 CBL TEAD3 GRB2 GAB2 SIRT1 PMC4258442__F3 Nitrosothiol signaling and protein nitrosation in cell death BAX FAS UNK FADD PMC6521150__F2 Proposed model for actinomycin D assembly (A) and 4-MHA precursor production (B) in S HEL-S-62p C2 APP ASMT PMC8395918__F7 Physalin A, 13,14-Seco-16, 24-Cyclo-Steroid, Inhibits Stemness of Breast Cancer Cells by Regulation of Hedgehog Signaling Pathway and Yes-Associated Protein 1 (YAP1) SMO YAP1 PMC9551033__F4 AMBRA1 and its role as a target for anticancer therapy STAT3 AMBRA1 SMAD4 PTEN SOCS3 CTNNB1 PMC7468493__F1 The signal transduction pathways associated with epithelial–mesenchymal transition (EMT) CDH2 BMI1 EGF HGF FOXK1 LGI2 CPEB2 TNF CTNNB1 SMARCA4 PMC8706716__F1 Targeting AKT in ER-Positive HER2-Negative Metastatic Breast Cancer: From Molecular Promises to Real Life Pitfalls? RHEB TSC2 BAD TSC1 PTEN MTOR PMC6387402__F1 Activation of signaling pathways in respiratory epithelial cells upon viral infection MAVS STAT2 IRF9 IRF3 TRAF3 TRAF6 MYD88 STAT1 TLR3 IFNAR2 TLR4 IFNAR1 TLR8 TLR7 JAK1 TYK2 PMC7217380__F2 PPI network and module analysis of HCC CYP2C19 MT1E MT1G PMC6602956__F6 Schematic diagram of NPY(1–36) expression and secretion in activated LX-2 cells and the signalling pathway involved NPY1R NPY MTOR ELF3 EIF4E PMC1183420__F1 Simplified 13-hydroxylation pathway of GA biosynthesis in vegetative tissue of pea SLN PMC11959038__F7 Association of LRP1B with the Hedgehog signaling pathway in CRC CDC2 PTCH2 SUFU PTCH1 CHEK2 SHH CDK2 LRP1B SMO CCNB1 CCND1 GLI3 PMC4615219__F1 Aberrant activation of alveolar epithelial cells (AECs) in lung fibrosis IPP CD151 SHH CTNNB1 PMC9709420__F6 Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in vivo validation HAL MAK APP FADD PMC4796823__F1 Identification of Potential Drug Targets in Cancer Signaling Pathways using Stochastic Logical Models STAT3 JUN BAD MCL1 MUC1 MTOR SRC MYC FOS EIF4E PMC5451598__F12 Schematic pathway illustrating the inhibitory effects of BMP4 on PDGF-induced calpain-2 activation, cell proliferation, and collagen synthesis in normal and PAH PASMCs TGFB1 BMP4 PAH PMC1440308__F6 Alternative Th network STAT1 STAT4 GATA3 PMC1440308__F7 Alternative Th network ITK STAT4 ATF2 TRAF6 GATA3 PMC2965566__F2 Transcriptional control of invariant NKT cell development DOK1 ZAP70 FYN BCL10 PMC8430321__F5 Network Pharmacology-Based Analysis on the Potential Biological Mechanisms of Sinisan Against Non-Alcoholic Fatty Liver Disease LOX PCOLCE TNF PMC7460810__F1 Biogenesis pathway of YRNAs and YsRNAs RAN RO60 RNASEL PMC5446478__F3 Biochemical and metabolic changes within the tumor ACLY GLS MTOR PMC7422677__F8 Index and biological spectrum of human DNase I hypersensitive sites ZNF331 TH FAS FYN ALK IL2 STAT4 LCK PMC5472375__F4 Based on GeneCodis3 analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, 23 significantly enriched pathways were revealed SLC26A3 SCEL SELE EGFR GRB2 TRAF6 INS TRAF2 AQP1 PMC3965409__F6 Positive Feedback Regulation of Proliferation in Vascular Smooth Muscle Cells Stimulated by Lipopolysaccharide Is Mediated through the TLR 4/Rac1/Akt Pathway TRIO TLR4 CD14 RAC1 MYD88 PMC11638059__F3 Few molecular mechanisms by which TAM affects EC CCL22 S100A8 CCR4 MMP9 VEGFA S100A9 PMC8198065__F2 PLysRS-Ap4A Pathway in Mast Cells Regulates the Switch from Host Defense to a Pathological State MSC MTOR PMC4948278__F2 Cancer stem cells supporting activities of CD44v6 HEL164 CD44 CAP2 MMP14 HGF MMP2 CD46 ARHA MMP9 CAP1 PMC4948278__F4 CXCR4, a marker of migrating cancer stem cells CD44 CRK BAD TSPAN8 SRC CXCR4 PMC7811571__F1 Graphical abstract NLRP3 TLR4 ACE2 IL1B PMC4948278__F5 EpCAM-palmitoylated claudin7 complex in pancreatic cancer stem cells CD44 EPCAM GEM HEL-S-28 PTEN SRC PMC7811571__F2 Main TLR4 signalling pathways TBK1 TLR4 TAB3 MAL IRF3 TRAF3 TRAF6 LBP IL1B MYD88 PMC9013884__F7 Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases TH STAT3 IFNGR2 NGF IFNGR1 FAS EGFR MMP2 GIP MMP9 FAAH PMC11596539__F3 UV damage and EGCG repair of collagen network layers in photoaged skin EGFR SMAD2 PMC7538181__F1 Transcriptional regulation of memory B cell differentiation CD40 STAT3 CCND3 SYK MEF2B IL21R EZH2 TCF4 IRF4 IRF8 MYC MEF2C ID3 CDKN2A TCF3 CDKN1A BCR CCND2 CDKN1B LYN BCL6 PMC7926484__F3 Dysregulated pathways governing liver hepcidin expression in PAH STAT3 BMP6 SMAD1 TFR2 DKFZp781O1323 SMAD2 SMAD4 BMP7 HAMP HFE PMC7538181__F3 Transcriptional regulation of memory B cell differentiation CD40 BACH2 TLE3 IRF4 MYC KRAS SKI CDKN2A CBL CDKN1A FOXO1 BCR BCL6 PMC8204445__F1 Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease HEL-S-90n KYNU KMO HAAO PMC6802331__F1 Schematic diagram of the JNK signaling pathway promoting cell death in ovarian cancer BAX CASP9 BCL2 PMC6862839__F4 Toll-like receptors (TLRs) in Lamellibrachia luymesi IRAK1 IRAK4 MYD88 PMC4414745__F4 Regulation of rice Hd3a and RFT1 expression by photoperiod EHD3 RFT1 EHD1 PMC6930256__F6 The networks of the PI3K-AKT signaling pathway related genes, representing the level of regulation of PI3K-AKT signaling pathway related genes compared with the blank control group in haemocytes, at various times when the HdAKT was inhibited by dsRNA TAX1BP3 PARVB EIF4B PARVA EIF4EBP1 TNFSF6 HEL-S-28 MTOR EIF4E RHEB MLST8 TSC2 RICTOR TSC1 RPS6KB1 IKBKB AKT1S1 HEL-S-1 AKTIP EIF4EBP2 PMC6802331__F3 JNK signaling pathway mediated drug resistance ATF2 PARP1 SIRT6 PMC5371185__F1 Schematic representation of the DNA damage response (DDR) pathway ATR WEE1 ATM PMC7908992__F3 Main molecular mechanisms involved in the antioxidant activity and the beneficial effects of dietary polyphenols in metabolic, cardiovascular, and neurodegenerative diseases ULK1 TFEB PMC6704558__F2 Signaling pathways for CSF-1 and FAK CDC42 MDM2 SRC PMC8282090__F8 KEGG pathways regulated by GPA2 or ASC1 as determined by sensitivity analysis UTP15 IMP3 IMP4 PWP2 UTP18 PMC2966110__F8 Stbd1 participation in glycogen metabolism and Stbd1 structure GAA GABARAP GABARAPL1 STBD1 PMC7108389__F4 TNFR and TLRs induced TNF signaling pathway MAP3K7IP1 TRADD USP4 OTULIN TAB3 RIPK1 TRAF6 TRAF2 USP48 FADD MYD88 PMC7108389__F2 Viral genome induced IFN production pathway via RIG-I and interacting DUBs USP25 TBK1 CGAS MAVS IRF3 IRF7 TRAF3 USP15 USP3 USP4 USP18 USP20 PLP2 USP21 CYLD PMC8910759__F3 Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders CD44 NLRP3 TRAF6 PMC7108389__F3 TLRs, IFNARI and IFNARII induced IFN production pathway USP25 TRADD STAT2 IRF9 TAB3 TRAF6 STAT1 MAP3K7IP1 USP18 RIPK1 JAK1 TRAF2 TYK2 CYLD FADD PMC8910759__F4 Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders SYK IL1R1 TLR4 IL33 CD14 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC9301043__F1 Pathogenesis of HCC Driven by NASH and the Preventive and Therapeutic Effects of Natural Products TG MTOR PMC7382586__F1 Regulatory mechanisms of linc-ROR in breast cancer SMAD2 ARF6 ZEB2 DUSP7 PMC9187756__F1 Four ferroptosis defense pathways SLC3A2 OMP GPX4 DHFR SLC7A11 DHODH PMC4838319__F2 De novo synthesis of CoA is a highly conserved pathway that consists of 5 enzymatic steps: pathothenic acid phosphorylation, cysteine conjugation, decarboxylation, conjugation to an adenosyl group and phosphorylation PPCS PPCDC PMC2790076__F5 Comparative Analysis of Gene Expression Patterns and Cell Phenotypes between Cervical and Peripheral Blood Mononuclear Cells CXCL9 CD80 PIK3CA PIK3R5 TIRAP NFKB2 TLR9 IRAK1 MAP2 TRAF3 TRAF6 IKBKG MYD88 TLR4 IL18 TLR8 CHUK TLR7 MAPK1 CD14 TLR5 IRF3 TNF CXCL10 RAC1 FOS SPP1 TLR1 MAP3K7IP1 IFNAR1 NFKBIA PMC11593403__F10 Characterization of phenotypes in melanoma cell populations resistant to dabrafenib or AZ628 MTCH2 FTH1 AXL GPX4 BRAF SLC7A11 CCNA2 CCND1 PMC6365902__F1 B-cell receptor pathway, which may be dysregulated in TNBC SYK BTK BCL10 BCR CD72 BLNK CD19 LYN GRB2 PMC8029610__F1 CGAS–STING pathway as a therapeutic target in inflammatory diseases TBK1 CGAS IRF3 IFNB1 PMC6365902__F2 MAPK signaling pathway, which may be dysregulated in TNBC MAX ECSIT JUN FAS CR1L LEP SELL APMAP CD14 TNF DAO FLNA APP NLK ERI1 PMC6105390__F4 Dietary fat and fiber interact to uniquely modify global histone post-translational epigenetic programming in a rat colon cancer progression model NR1H4 ENTPD5 PPARG CADM1 VLDLR PLK2 LPCAT3 SLC9A3 SLC27A2 MGLL CCL5 ACADM PYGL SLC23A2 HLA-E MTTP DGAT2 ABCD3 CPT2 NFKBIZ ABCB1 SLC26A3 IFNGR1 SCD HLA-DQA1 AQP8 CXCL10 ALDH3A2 BHLHB2 EMP1 CYP2C18 BMP6 EPB41L4B SLC51A CYP4F12 CYBB RBP7 PLA1A NCEH1 FA2H FABP1 ADTRP SLC25A20 NR1C2 ACTN2 CYP4B1 IL1R1 HEL-S-128m ARNT2 SSTR2 PPARGC1A ABCG2 SLC1A1 ARG2 GNAI1 SLC22A3 GZMA CTH GJB2 AXIN2 NR3C1 DIO1 NR1C1 NR2A1 PDK4 DBI ACADL MAP2K1 SLC13A1 LBP CPT1A PMC2898064__F3 Overlay of predicted functional interactions onto a human curated GBM pathway from the TCGA data set HRAS SP2 ATM KRAS PMC6365902__F3 mTOR signaling pathway, which may be dysregulated in TNBC RHEB TH PTEN RHO MTOR SESN2 RNF152 DEPTOR PMC6956866__F3 Pue for different pathways CD40 IFNG ARG1 CD163 CXCR4 ATG5 PMC9322024__F2 Antiaging Mechanism of Natural Compounds: Effects on Autophagy and Oxidative Stress KEAP1 TFEB SFN MTOR VCP SIRT1 PMC8029610__F2 CGAS–STING pathway as a therapeutic target in inflammatory diseases BAX TBK1 CGAS APC IRF3 SLC19A1 ENPP1 IMPACT PMC9187756__F4 Various roles of p53 in ferroptosis SLC7A1 CDKN1A DPP4 FACL4 ALOX15 ALOX12 SLC7A11 PTGS2 PMC8354203__F3 Downregulation of miR-142a Contributes to the Enhanced Anti-Apoptotic Ability of Murine Chronic Myelogenous Leukemia Cells MYB CIAPIN1 TIRAP E2F2 TIGAR IRF8 PMAIP1 CEBPA CDK6 RAD17 PIR CER1 BIRC2 PMC7718954__F4 cGAS‐STING signaling pathway TBK1 CGAS OMP IRF3 PMC8441965__F7 Inhibin BA is an independent prognostic factor that promotes invasion via Hippo signaling in non-small cell lung cancer FRMD6 INHBA WWC1 PMC7604619__F3 Kinase pathways deregulated in Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) FLT3 ABL2 CRKL EPO NTRK3 MTOR KRAS POR IL2RB PDGFRA FGFR1 NRAS BCL2 SH2B3 LYN JAK1 PMC3310875__F6 Progesterone Receptor Activates Msx2 Expression by Downregulating TNAP/Akp2 and Activating the Bmp Pathway in EpH4 Mouse Mammary Epithelial Cells SMAD1 DKFZp781O1323 BMP4 BMP2 MSX2 PMC8930095__F2 Talin-1 interaction network in cellular mechanotransduction (Review) F2 F3 ARHA PMC7718954__F1 Necroptosis, apoptosis, and pyroptosis signaling pathways RIPK3 BAX GSDMD MLKL RIPK1 TNF IL1B PMC5139081__F8 CF airway epithelium and pathogen adaptation CFTR MYD88 PMC3499061__F2 Schematic illustrations of the two significant pathways in the genome-wide gene self-reported asbestos exposure interaction analysis TAPBP FAS CAD CANX MHC2TA EGFR FAT1 CTSS CD47 FADD PMC8184946__F8 Graph indicates the mechanisms of how TRPM2 promote pancreatic cancer proliferation and tumorigenesis TRPM2 CCND1 MEF2C PMC8634864__F2 Evolution of memory system‐related genes CA12 MAL SRC PMC4147963__F1 Natural killer cell cytotoxicity (NKCC) FAS CAD FADD PMC6530346__F5 Effect of chronic treatment with PDF and addition of AlaGln on individual pathways TF TH HEL111 RHO CS THRA AHSG APOH F2 NF2 NACA CRP GAA SERPING1 AMBP PLG HRG HAMP IL6 HEL-S-78p LBR HEL-S-92n FGA HP LBP CP PMC6391774__F4 Levels of regulation of NKG2DL expression EGF SP1 HSF1 MTOR TNF PMC4640466__F2 Noncanonical Wnt/calcium pathway CDC42 ROR2 RYK ARHA NLK DAAM1 PMC4640466__F3 Wnt inhibitors currently in clinical trials APC GSK3B LRP5 LRP6 CTNNB1 PMC4640466__F1 Canonical Wnt signaling.Notes: (A) Wnt off APC GSK3B LRP5 LRP6 CTNNB1 PMC2744654__F5 ProMeTra visualization of relative metabolite pools and transcript abundances during fermentation of the l-lysine producer C DLD ACR PMC3243479__F3 Fatty acid Beta-oxidation, TG synthesis, and phospholipid biosynthesis pathways MADD PSD PEMT DMD PMC6029485__F1 IGF signaling pathway TSC2 BAD TSC1 IGF1 IGF1R ARHA GRB2 MTOR IRS1 EIF4E PMC5741523__F1 Hepatitis B Virus Persistence TBK1 MAVS TLR4 IRF3 PMC6029485__F2 IGF signaling pathway in pulmonary fibrosis EGR1 IGF1 EGR2 FOS PMC6823181__F1 GPER signaling pathways in cancer cells BAX EGFR RHO FOS PMC4857136__F1 Signaling pathways frequently deregulated in MDS TF STAT1 TRADD STAT2 TRAF1 TRAF2 FADD PMC2910246__F8 Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: Apoptosis through the formation of 3-hydroxykynurenine STAT1 JAK1 PMC4408919__F3 Opposing effects of target overexpression reveal drug mechanisms DHFR FPGS DHPS PMC7011253__F1 Schematic diagram of Chinese medicines direct and indirect regulating NFKB pathway in UC treatment STAT3 TLR4 MYD88 PMC3818951__F1 Osteoclastogenesis RB1 CTSK TRAF6 PMC8138161__F4 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway BAX CCND2 ATG5 PMC8872619__F3 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells CDC2 FOXM1 EGFR PMC12024444__F3 The Hippo signaling pathway in osteoclasts LATS1 RASSF2 LATS2 NFATC1 AJUBA TRAF6 RUNX2 PMC8138161__F5 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway BAX BCL2 MTOR ATG5 PMC8872619__F4 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells RHEB ATR HIPK2 HEL-S-69p ATM PTEN MDM2 PMC8138161__F2 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway FAS CAD FADD PMC10311114__F2 Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges ADIPOR1 ADIPOR2 PMC12024444__F1 Hippo signaling pathway regulates cell homeostasis under many factors LATS1 LATS2 PAK1 RHO RUNX2 RAC1 PMC8872619__F2 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells RBL1 FOXM1 E2F2 EGFR CCNA2 CCNB1 PMC8138161__F3 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway BAX FAS ULK1 F2 MTOR ULK2 FADD PMC12024444__F2 YAP/TAZ have different regulatory effects on different stages of osteogenic and chondrogenic differentiation COL1A1 SOX9 VGLL3 DPM1 MSC MX1 COL10A1 NFATC1 RUNX2 CTNNB1 PMC7366109__F5 KEGG signaling pathway enrichment network of Pre-No PPARG EGF BAD PTEN MTOR MYC CCL2 MAPK4 RB1 BCL2L1 PRKCE INSR NR3A2 PRKCA KDR MDM2 JUN PIM1 IL4 CXCL2 CD40LG VEGFA FOS DIO1 NR1C1 RELA RXRA PMC8138161__F1 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway LAMP2 ATG3 ATG12 ULK1 UVRAG AMBRA1 MTOR ATG5 ULK2 PMC3445776__F1 The Hedgehog signaling pathway SUFU PTCH1 SMO PMC8872619__F5 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells TF NKX3-1 BAD PLAT CDK2 BCL2 PTEN ERG CCND1 PMC8535862__F2 Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer DIRAS3 STAT3 SUMO1 ULK1 FOXO3A UVRAG AMBRA1 NRBF2 ATG14 BCL2 KLF10 SRC PMC11036658__F9 Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer CDC2 BAX MTOR PMC4335789__F1 Mechanisms that promote resistance to PI3K pathway inhibition PTEN MTOR PMC8138161__F6 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway CA12 TLR4 MTOR PMC4905241__F1 Cell cycle-dependent regulation of E2F1 PRMT1 C6 ATM MYC SKP2 PMC4905241__F2 DNA damage-dependent regulation of E2F1 PRMT1 BAX NEDD8 ATR BCL2 ATM MDM2 APAF1 SETD7 PMC11395567__F2 Simplified illustration of the signalling pathway depicting priming and activation of the NLRP3 inflammasome GSDMD TRADD NLRP3 IRAK1 IRAK4 FADD BRCC3 MYD88 PMC11279438__F1 Vitamin D’s role in skeletal muscle NR1i1 DBP FOXO3A CUBN PMC11279438__F2 Relationship between oxidative stress and weakness of muscle TNF SIRT1 HEL-S-44 PMC8328045__F5 Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron ABCG1 TLR4 ATF1 TNF IL1B CD34 PMC4905454__F3 Cancer stem cells and signaling pathways in radioresistance CD44 BAX TGFA MTOR NOTCH2 NOTCH1 CTNNB1 PMC7721054__F2 Anatomy of an mRNA ELF2 ELF3 EIF4E PMC8328045__F3 Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron SYK NLRP3 TLR4 VCAM1 MYD88 PMC11279438__F3 Antioxidative role of vitamin D in muscle dysfunction OPA1 KEAP1 MFN1 FOXO3A MFN2 SIRT1 PMC7985100__F3 Signaling pathways and gene regulation on NLRP3 inflammasome RIPK3 NLRP3 DICER1 TXNIP MLKL RIPK1 CTNNB1 PMC8440972__F3 Houttuynia cordata Thunb: An Ethnopharmacological Review BAX KEAP1 PMC4584313__F2 Hedgehog Signaling in Malignant Pleural Mesothelioma SUFU SMO GLI3 PMC11566155__F10 Novel function for Alpha-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction EPHA4 RHO NCK2 PMC4905454__F1 Cancer stem cells and signaling pathways in radioresistance BAX BAD TGFA BRCA2 PIR CDK2 MTOR PMC4849016__F2 Regulation of RNase 7 induction STAT3 EGFR ATF2 PMC10394732__F2 Mechanisms involved in mutant p53 exerting GOF effects TF CDC2 BAX IL7 SMARCD1 MYC PMC3245324__F2 Ischemic preconditioning (IPC): signaling pathways and targets PTEN MTOR SRC PMC5541046__F7 Working model of the EphA4–ephexin1 signaling pathway and BDNF-TrkB signaling pathway in the model of depression CDK5 FYN EPHA4 BDNF PMC8699295__F3 TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer EGF TRPM7 FOXC2 EGFR SOX4 PMC11720051__F2 Diagram of Hippo Signaling Pathway “on” & “off” states LATS1 MOB2 LATS2 MTF1 NF2 PMC7579731__F1 Contemporary treatment approaches for metastatic colorectal cancer driven by BRAF V600 mutations EGFR APC GSK3B BRAF GRB2 MTOR CTNNB1 PMC3602516__F1 Identification of Small Molecule Activators of BMP Signaling SMAD1 DKFZp781O1323 BMP2 SMAD6 SMAD4 ID1 PMC11173247__F8 Wound-induced genes involved in plant–insect interactions in arabidopsis WT and lox2 mutants MYB RGL3 PRX MYC PMC5214941__F2 Proinflammatory role of extracellular interleukin (IL)-1A HAX1 IL1R2 IL1R1 PMC4050127__F1 Targeting LIM kinase in cancer and neurofibromatosis LIMK2 NF1 ARHA RAC1 PMC7655196__F1 Summary scheme of MerTK-mediated macrophage HSC crosstalk pathway in fibrotic NASH TGFB1 ADAM17 MERTK PMC7326904__F1 Evaluation of Silencing Effect of miR-133a-5p Mimic on TIM-3 Expression in AML (HL-60) Cell Line ECSIT JUN FAS TRADD GRB2 NLK GCK TNF TRAF2 PMC4045235__F3 CUL7-OBSL1-CCDC8 pathway and its predicted role in cell growth INSR CUL7 IRS1 PMC10925900__F7 Amyloid-Beta-Induced Dendritic Spine Elimination Requires Ca2+-Permeable AMPA Receptors, AKAP-Calcineurin-NFAT Signaling, and the NFAT Target Gene Mdm2 NFATC4 HEL-S-62p NFATC3 MDM2 PMC8526962__F4 Everything Old Is New Again: Drug Repurposing Approach for Non-Small Cell Lung Cancer Targeting MAPK Signaling Pathway CASP9 BAD ALK POLK EGFR PMC8526962__F5 Everything Old Is New Again: Drug Repurposing Approach for Non-Small Cell Lung Cancer Targeting MAPK Signaling Pathway EGF TGFA GRB2 PMC6540369__F1 a Biosynthetic pathway of glycyrrhetinic acid constructed in S IPP ID2 PMC6703648__F7 Proposed model for the role of the Rb/E2F pathway in the coordination of proliferation and differentiation during neurogenesis DLX1 E2F7 DLX2 PMC4917665__F2 Metabolic pathway of aerobic glycolysis, FAS and FAO ACLY HEL-S-133P HK2 FASN ME1 CPT2 PMC9290266__F8 RA signaling pathway combined with Wnt signaling pathway regulates human-induced pluripotent stem cells (hiPSCs) differentiation to sinus node-like cells HCN4 TBX18 CACNA1G BMP4 SHOX2 TBX3 TBX5 SCN5A PITX2 PMC8670263__F1 CGAS–STING pathway: more than fighting against viruses and cancer TBK1 CGAS IRF3 PMC8253380__F1 Mechanistic Overview of Taste Bud Maintenance and Impairment in Cancer Therapies ASCL1 SHH GPR49 HES1 PMC8253380__F2 Mechanistic Overview of Taste Bud Maintenance and Impairment in Cancer Therapies PORCN SUFU LRP5 LRP6 SMO CTNNB1 PMC5144577__F1 Canonical Notch signaling and Notch conservation between human and Monosiga brevicollis EGF JAG2 NUMB PMC5874734__F1 Induction of necrosis by L RIPK3 MLKL IRF3 IMPACT PMC6678606__F1 Stearoyl-CoA desaturase 1 (SCD1) as a molecular target for anticancer therapy EGF HEL-S-53e EGFR GSK3B PTEN CCND1 CTNNB1 PMC6514153__F3 Reelin signaling pathway in Golgi Dynamics and morphology CDC42 DAB1 CLASP2 VLDLR LIMK1 GSK3B SRC RAC1 PMC11087106__F7 High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NFKB and PI3K/AKT/mTOR signaling pathways in rats BAX MTOR TNF PMC5474195__F2 Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy RHEB PTEN CTNNB1 EIF4E PMC5797575__F8 Proposed scheme of the possible mechanisms associated with the effects of asiaticoside (AS) on attenuation of cell growth inhibition and apoptosis induced by AB1-42 in human brain microvascular endothelial cells (hBMECs) TLR4 TRAF6 MYD88 PMC4490961__F2 Interaction of the TFF2-CXCR4 axis with the active RAS-RAF-MEK-ERK pathway in the serrated pathway of colorectal cancer TFF2 EGF EGFR CXCR4 PMC7281527__F1 Canonical microRNA (miRNA) biogenesis pathway DGCR8 STAR DROSHA PMC4308035__F1 Proposed pathways by which prostate cancer cells activate AR signaling, including variants (AR-Vs), and thus acquire resistance to AR-directed therapy IGF1 IL6 PMC4199664__F1 Cell cycle regulatory pathways CDC2 CDK6 NF1 EGFR HIF1A TIGAR SCO2 MTOR CDK4 PMC7565308__F5 Systems biology analysis TES SRPRB RAN HEL113 RAB21 EPCAM ALDH2 TFRC GRB10 YWHAQ TPD52 MYH9 FDPS HEL-S-15 NOS2 POLM MYOF FASN ANXA1 HEL-S-30 HEL-S-94n RPL23 HEL114 ANXA11 CASP3 HEL-S-87p SND1 LMNA PMC8406742__F2 Neutrophil Extracellular Traps in Cancer HMGB1 CEACAM1 EGFR KRAS IL1B MPO PMC7411791__F1 Toll-like receptor (TLR) signaling in response to viral infection TBK1 TLR4 IRAK1 RIPK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC8748997__F8 The proposed model SOCS1 IFNAR2 IFNAR1 ARG1 MTOR TYK2 PMC3845556__F1 Targeting the PI3K-AKT-mTOR signaling network in cancer RHEB TSC2 TSC1 IGF1 PTEN MTOR IGF2 PMC7565308__F6 Global subnetwork analyses SYK CD79A TNFAIP3 CARD11 FAF1 PTEN MTOR TRAF3 MYC TRAF6 PRKCB BIRC5 BCL2L1 BTK BCL10 PLCG2 MAPK1 RPS6 BAX CASP8 IL6 TNF NR3C1 EIF4E FKBP5 NFKBIA BCL2 LYN CASP10 FADD PMC7859290__F1 Biosynthesis of the molybdenum cofactor (Moco) and metabolic pathway of sulfur amino acids and purine degradation MOCS3 GPHN MOCS2 PMC4033628__F2 Synthesis of representative structures along the Golgi-centric core M1 and M2 glycan synthesis pathways B3GAT1 POMT2 POMT1 POMGNT2 FUT9 PMC7897327__F2 m6A RNA modification regulates hematopoietic system development MAVS YTHDF2 BCL2 PTEN METTL3 EIF2A CCND1 AXIN2 PMC4033628__F3 Representative core M3 structures that are dependent on multiple initial activities based in the ER POMT2 POMT1 POMGNT2 POMK B3GALNT2 LARGE2 PMC7349681__F2 Types of extrusion S1PR2 RHO PMC12254754__F2 Schematic illustrates that inhibition of GLUT1 results in an increase in the tumor OXPHOS pathway, leading to excessive production of ROS, which subsequently promotes TNFAlpha-mediated cell death CXCL9 CXCR3 CXCL10 PMC6933354__F6 Schematic model indicating that SPRY4‐IT1 competitively binds to miR‐217 and TCF7L2, consequently regulating the Wnt/B‐catenin signalling pathway to promote stemness of breast cancer cells TCF7L2 APC GSK3B CTNNB1 PMC9542654__F4 Exploration of hub genes involved in PCOS using biological informatics methods SYK BAD RBL2 PTEN CD19 MYC RAC1 IRS1 EIF4E RHEB TSC2 TSC1 BRCA1 BCR CD37 RXRA MDM2 CP PMC8383754__F3 Identification of HIF-1A/VEGFA signaling pathway and transcription factors in Kashin-Beck disease by integrated bioinformatics analysis NOS2 CASP9 JUN CYCS APOE MMP9 MTOR SPP1 CD44 IFNG FOXO3A HEL-S-102 CASP3 MMP2 APP CREB1 CCND1 PS1TP5BP1 IL1B PMC9608206__F2 Clinical implications of the interaction between PD-1/PD-L1 and PI3K/AKT/mTOR pathway in progression and treatment of non-small cell lung cancer STAT3 PTEN MYC MXI1 CTNNB1 EIF4E PMC11002130__F4 tsRNAs as inhibitors of MAPK pathway activation via targeting MAPK-related proteins CDC42 RHO BDNF CCND1 PMC8383754__F5 Identification of HIF-1A/VEGFA signaling pathway and transcription factors in Kashin-Beck disease by integrated bioinformatics analysis NOS2 DBP MAFK JUN JUND TIMP1 MAFG MAFA JUNB PIK3R1 MTOR VEGFA IL6 FOS PRKCB MAPK3 IFNG HMOX1 NFE2 HEL-S-162eP RELA NFE2L2 BCL2 PMC2659375__F2 MET as a target for treatment of chest tumours CDC42 PXN RHO GRB2 SRC PMC8317503__F1 Knockout Gene-Based Evidence for PIWI-Interacting RNA Pathway in Mammals SPOCD1 TDRD1 DNMT3L DDX4 HIG-1 TDRD12 TEX15 TDRD6 PMC7393201__F7 Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1A pathway BAX TGFBI FGF21 FGFR1 IL1B PMC4307801__F1 HER2-Positive Breast Cancer: Current Management of Early, Advanced, and Recurrent Disease BAD PTEN GRB2 MTOR SRC CCND1 PMC5486146__F1 Thyroid cancer hystotypes and their causative genetic events PAX8 BRAF PTEN CTNNB1 PMC4270129__F1 This figure shows the VEGF pathway for angiogenesis CXCL1 IL8RB CXCL8 APAF1 PMC4829549__F2 MET signaling pathway STAT3 BAD HGF MDM2 GRB2 MTOR SRC PMC8728240__F2 Priority index: database of genetic targets in immune-mediated disease TH PML MYC TRAF2 PMC3526895__F9 Schematic model of the signaling pathway activated by redox/metabolic imbalance and its possible positive impact on human lifespan GCLC NFE2L2 PPARGC1A PMC9312948__F2 Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors SIRT3 HIF1A SRC MYC PMC9228579__F3 Immunobiology of Nipah Virus STAT3 STAT1 STAT2 IRF9 STAT4 TYK2 PMC8074097__F6 Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy BAX BAD RPIA IL16 PMC4690264__F1 Type I IFN signaling pathway and transcriptional changes of selected ISGs in the spinal cord of TMEV- compared to mock-infected SJL/J mice MX2 MX1 ISG15 PMC6747431__F5 The different expression of HH (hedgehog) signaling RAB20 SHB PLG SMO HEL-S-11 PMC3464048__F1 Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets STAT3 FAS RAF1 MTOR FADD PMC3464048__F2 Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets STAT3 SRC MYC PMC1849962__F5 Regulatory networks model of GSL biosynthetic pathway in Arabidopsis accession Columbia CBL F2 F11 PMC12242330__F1 Phenylpropanoids metabolism: recent insight into stress tolerance and plant development cues CAD PRX PMC12093320__F1 Genes encoding downstream NFLs evolve at a slower and more consistent rate comopared to genes encoding upstream NFLs LATS1 SOCS1 DKK3 TRIM38 LATS2 CITED2 HHIP PTCH1 SIGIRR HES1 AXIN2 CTNNB1 PMC6044425__F2 The N-linked protein glycosylation pathway ALG5 DPM2 DOLK ALG6 ALG10 DPM1 ALG13 ALG1 GFPT1 ALG3 DPAGT1 DPM3 PMC8470960__F2 Effects of Intermittent Fasting on Brain and Cognitive Function HEL-S-5 MTOR BDNF PMC2756474__F7 CREB Mediates Prostaglandin F2Alpha-Induced MUC5AC Overexpression IL1R1 MUC5AC COX2 IL1B PMC4110182__F1 SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease GEMIN2 GEMIN5 GEMIN6 GEMIN7 GEMIN8 LSM6 HNRPR LSM1 LSM3 LSM5 LSM8 LSM7 LSM4 LSM2 PMC6469489__F1 Multiple pathway stimulation of ADAM activity, leading to sAPPA proliferation and notch stimulation EGF EGFR APP PMC11604893__F1 Tumor energy metabolism: implications for therapeutic targets HEL-S-133P HEL-S-162eP PDC MTOR HEL-S-30 PMC9072795__F1 Molecular signaling in temporomandibular joint osteoarthritis MED12 GAL ADAMTS4 FGFR1 ADAMTS5 IHH FGFR3 SMO ADAM10 CTNNB1 GLI3 PMC4440618__F5 Chlamydia pneumoniae Inclusion Membrane Protein Cpn1027 Interacts with Host Cell Wnt Signaling Pathway Regulator Cytoplasmic Activation/Proliferation-Associated Protein 2 (Caprin2) APC LRP5 LRP6 CAPRIN2 CTNNB1 PMC11604893__F3 SWI/SNF complex regulating tumor metabolismThe purple gene and arrow represent glucose metabolism ACLY PPARG ACOX1 HEL-S-133P PFKP SCD FASN FBP1 SMARCD3 HEL-S-30 SMARCA4 PMC6225799__F6 Activation of the interferon-ɣ/STAT1 pathway SOCS1 BAX AK2 PMC5817726__F2 Role of Bruton’s tyrosine kinase downstream of the B cell receptor SYK BTK RAF1 BCL10 BCR PLCG2 PI3 CARD11 CD19 PTEN LYN MYC PMC10855951__F5 Transcriptomic Analysis Provides Insights into Candidate Genes and Molecular Pathways Involved in Growth of Mytilus coruscus Larvae KIF3A KIF7 E2F4 SUFU SMAD2 SMAD4 SMO GLI3 PMC6224961__F2 Regulation of priming and fusion of insulin granules by glucose and the incretin GLP-1 CFTR SNAP25 PMC7259377__F6 GLS1-mediated reduction of oxidative stress is associated with increased phospholipid synthesis and the activation of folate and methionine cycles PTDSS2 TG HEL-S-182mP PTDSS1 PEMT CTH PCYT2 HEL-S-61p MTHFS HEL-S-64p MAT1A PISD PMC7246647__F2 Oncogenic FGFR signaling in gastrointestinal stromal tumors (GISTs) FGF7A CTCF PMC6206165__F9 Model showing possible mechanism for regulation of ovarian development by four key miRNA/gene pairs SFRP4 FZD4 SMURF1 APC NR5A1 SMAD4 SMURF2 CTNNB1 PMC7246647__F1 Fibroblast Growth Factor Receptor (FGFR) structure, ligand binding and signaling TK1 GRB2 PMC4221550__F3 smicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma EGF NGF MOS c-fgr EGFR BRAF GRB2 MYC PMC8131586__F6 Illustration of the positive feedback loop between tamoxifen-resistant ER-positive breast cancer cells and M2-like TAMs STAT3 EGF EGFR ARG1 PMC10244098__F2 N7-methylguanosine modification: from regulatory roles to therapeutic implications in cancer TGS1 WDR4 RNMT PMC7072743__F2 Activation of the mechanistic target of rapamycin (mTOR) RHEB MLST8 TSC2 RICTOR TSC1 MTOR IRS1 PMC2857869__F4A Metabolic Engineering for Production of Biorenewable Fuels and Chemicals: Contributions of Synthetic Biology HPR NADK PMC3049838__F3 Wnt signaling pathway activation in R1A deficient tumor cells APC GSK3B LRP5 CTNNB1 PMC3800433__F1 The central role of group 2 innate lymphoid cells (ILC2s) in type 2 immunity IL25 TSLP EGFR IL33 AHR PMC2742089__F3 A biochemical pathway of secreted proteins that regulate D-V patterning in Xenopus BMP1 BMP4 BMP2 BMP7 PMC5607250__F9 Predicted regulation relationships between differentially expressed miRNAs and target genes based on KEGG pathway PRLR XDH PMC8127529__F2 Azithromycin: Immunomodulatory and antiviral properties for SARS-CoV-2 infection TMPRSS2 ADAM17 ACE2 PMC4632976__F1 The intracellular parasite Toxoplasma gondii depends on the synthesis of long chain and very long-chain unsaturated fatty acids not supplied by the host cell ELOA ELOC PMC6690620__F1 Biochemical pathway of the creation of homocysteine and specific enzymes/vitamins necessary for conversion to methionine vs PMC8642426__F2 Pharmacological insights into autophagy modulation in autoimmune diseases CGAS ATG3 ATG16L1 TLR3 ATG12 ULK1 IRGM NOD2 PARK2 ATG5 PMC2785619__F2 Up-regulation of TGFB signaling in Timp3−/−-AB hearts SKIL SMAD1 JUN SMAD2 LIF RUNX2 FOS SKI RUNX3 SPP1 MAPK3 TGFBR2 BAMBI IFNG ENG INHBA FST NOG BMP4 FKBP1A CREBBP PMC4249087__F8 The UPR-induced HAdV infection boost by GCA C2 GCA PMC3520888__F1 Escorting Ras CHMP6 RIN1 EGFR VPS4A PMC3192435__F2 Targeting the PI3K/Akt/mTOR pathway to treat lymphoma RHEB TSC2 TSC1 PMC6788945__F3 Sex-differential regulatory network CBLN3 SCEL FOXO4 TPO CTSS SDR39U1 KIZ PMC3535856__F6 Proposed mechanism for MCME-mediated inhibition against migration of CL1 cells SRC CTNNB1 PMC6962451__F5 The proteome landscape generated by the direct comparison between cells differentiating in alginate capsules and Matrigel differentiated-cells NR1C1 BRCA1 RXRA ATM PTEN RHO MTOR PMC5682960__F7 Working model of the action of PEDF + DHA in enhancing corneal nerve regeneration VIP NGF SPRR1A PLG NPY BDNF SEMA7A PMC2575530__F2 Insulin-like growth factor-I signaling pathway involved in breast cancer BAD IGF1 SOS1 GSK3B PTEN GRB2 MTOR IRS1 PMC9113874__F7 Transactivation at C-TAD Domain of HIF-1A by Factor-Inhibiting HIF-1A (FIH-1): A Potential Target for Therapeutic Intervention in Cancer TH HIF1A UNK PMC7037626__F1 Protein interaction network of MMPs, collagen II and aggrecan CXCL12 ADAMTS4 SPARC PCOLCE CHAD PZP TNR ITGAV LPA NGF MMP26 MBP BCAN MMP2 MMP3 PRELP CRP MMP19 UMOD PLAUR TNFSF6 MMP17 HAPLN1 ITGA2B ACAN HBEGF BMP2 MMP20 PMC3055988__F2 Further implications of G-/GM-CSF-induced JAK-STAT signaling in peripheral sensory neurons SCN10A STAT3 KCNK2 KCND2 TRPV1 PMC10304636__F4 Schematic diagram representing cardioprotective molecular mechanisms of GLP-1 analogs in cardiomyocytes BAX GLP1R DRP2 BAD MFN1 MFN2 MTOR GPX1 PMC9258689__F5 Interaction mechanism of nickel ions with L929 cells based on integrative analysis of proteomics and metabolomics data MAP3K7IP1 ALDH18A1 SRM PYCR2 PMC8330049__F1 Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies PLN NF1 GRB2 SRC PMC9258689__F4 Interaction mechanism of nickel ions with L929 cells based on integrative analysis of proteomics and metabolomics data GATA1 GPX4 LAP3 SRM HEL-S-26 GPX1 PMC8180257__F7 MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus ROR1 FOXJ1 ROR2 MEIS1 PMC4949768__F1 Central carbon metabolism model for M HPR MAL CIT PMC5849286__F1 Sphingolipids and Redox Signaling in Renal Regulation and Chronic Kidney Diseases SMS tmp_locus_29 HEL-S-5 PC PMC4947675__F1 Non-canonical autophagy in the clearance of dead cells ULK1 UVRAG ATG5 PMC5899024__F6 For Therapeutic Targeting of AKAP Signaling Complexes in Nervous System Disorders CNTF LRRK2 HEL70 BDNF PMC8412110__F5 Cdc42 signalling in cell migration CDC42 STAT3 DOCK10 ARHA RAC1 PMC3690396__F7 Regulation of the Hippo pathway by cAMP-PKA signaling LATS1 LATS2 RHO PMC8038986__F1 Contribution of cell death signaling to blood vessel formation RIPK3 BAX MLKL BCL2 PMC8990811__F1 Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation CD226 CD40 TH ICOSLG CD80 CD2 PDCD1 HLA-DRB1 APC CD22 PTPRC CTLA4 SPN ICOS CD58 TIGIT HLA-B CD6 PMC6917045__F2 Interplay between the UFM1 pathway, ER stress and cell fate UBA5 UFC1 UFM1 ATF4 SRC PMC6917045__F3 Control of proteostasis by the ufmylation pathway TF UFL1 UFC1 UFM1 RPL26 PMC12185702__F6 MAPK/OIS/SASP axis in pLGG cells ATR GSK3B GFPT1 IL6 PLK1 IRS1 CDK6 AURKB POU5F1 CDK2 ATM HEL-S-44 CDK4 IL1B PMC3335094__F3 Mechanical Strain Regulates Osteoblast Proliferation through Integrin-Mediated ERK Activation MAX ECSIT FAS MOS NF1 CD14 ATF2 GRB2 NLK FLNA MEF2C PMC11648424__F2 Compound target–protein–protein interaction functional enrichment network of A PPARG SYK PIK3CD MAPK9 IRAK4 MAPK3 HDAC3 ADRBK1 MAPK14 DRD1 MME FGFR1 PTGS1 ITK FLT1 PARP2 MDM2 CPT2 HEL-S-26 SRC HDAC2 ABCB1 CCR1 EPHX2 MAPK1 DYRK2 AXL SCD TRPV1 HEL-S-28 SNCA NEK1 CBFB HMGCR HPGD AURKB SIRT1 CDC25B SETD7 CDC42 CA7 BRD4 SLC10A2 TBK1 HTR7 BAD MAPK11 MAPK13 LAT FABP1 AKT3 DHFR BRAF NR1C2 TERT MTOR TGFBR1 PLAA DUSP3 BTK REN NAAA TTL SLC6A3 QPCT F2 ALDH3A1 TTK ACKR3 CNR1 HDAC11 HDAC6 CDK4 CDC2 ACHE P2RX3 BRD3 PTPN1 KIT CLK2 FABP4 TRHR PARP1 HDAC1 NR1C1 CXCR1 GSK3A CALCRL RPS6KB1 NTRK1 CREBBP MAP2K1 LCK PMC5688007__F2 Mitochondrion: a central architect of copper homeostasis SIRT3 SCO1 COX19 HEL-75 HEL-S-44 ATP7A PMC4603304__F5 Signaling pathway analysis of the potential mature EBOV miRNA target genes HEL-S-62p SELPLG NFKBIE CRYAA RIPK1 TBP PMC6349928__F1 Non-coding RNAs as integrators of the effects of age, genes, and environment on ovarian aging FOXO3A PTEN AMH PMC2899674__F1 Molecular pathway for arterial, venous and lymphatic cell fate determination in vertebrate embryo EPHB4 PROX1 FOXC1 SOX18 SOX7 PMC4367606__F2 Tumor cell ligands recognized by human GD T cells IPP NECTIN2 ULBP3 MBP APC ULBP1 MICA MB MICB PMC9170129__F10 Evidence for Neuropeptide W Acting as a Physiological Corticotropin-releasing Inhibitory Factor in Male Chickens JUN NPBWR2 NPW CRH POMC MC2R PMC6487485__F1 Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut Microbiome CYP8B1 GCA HSD3B7 CYP7B1 CYP27A1 PMC11849638__F9 Schematic depiction of the PKA/SHP2/STAT1 pathway STAT1 STAT2 COX2 IFNAR2 IRF9 IFNAR1 PDE4D JAK1 TYK2 PMC5055439__F1 Stem cell metabolism PML HIF1A MTOR PMC4404318__F1 Toll-Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework BTK TLR3 TIRAP TLR4 CD14 IRF3 IRF7 TRAF3 TRAF6 MYD88 PMC8183764__F1 Fructose and metabolic diseases: too much to be good KHK ALDOB FASN GCK PKLR PMC6388657__F6 IPA to identify the signaling pathway associated with the differentially expressed proteins across all the conditions studied TH AHSG SERPINF2 HEL111 CFH TEF PMC3877388__F6 Syndecan-1 (CD138) Modulates Triple-Negative Breast Cancer Stem Cell Properties via Regulation of LRP-6 and IL-6-Mediated STAT3 Signaling STAT3 CD24 LRP6 CCL20 IL6R PMC6288499__F1 Epidermal growth factor receptor pathway in patients with wild-type and mutant BRAF and KRAS EGFR BRAF KRAS PMC8809363__F1 Recent Advances in the Role of Arid5a in Immune Diseases and Cancer STAT1 ARID5A TLR4 PMC6910185__F4 A diagram of mechanistic insight of genistein (Gen) to induce apoptosis in cancer cells BAX DNASE1 ATR FAS HIPK2 HK2 ATM PTEN MTOR TNF IL1B PMC6910185__F5 Molecular targets of genistein (Gen) in cancer cell cycle CDC2 EGF ATR EGFR CDK2 ATM PTEN MDM2 NOTCH1 PMC6910185__F6 Schematic representation of antiangiogenic activity of genistein (Gen) in cancer STAT3 VASP PTEN ARHA RHO MDM2 MTOR SRC FOS YAP1 PMC6910185__F7 Illustration of antimetastatic potential of genistein (Gen) in cancer TIRAP TLR4 EGFR NQO1 MAF ATF2 MMP9 IL1B MYD88 PMC12185702__F2 Mapping of the multi-omics MAPK/OIS/SASP axis in pLGG cells GATA2 AURKA GAP43 NFATC2 GSK3B MARCKS HIF1A ADD2 ATF2 MYC PLK1 NFIL3 MAPK3 MAPK14 EGLN1 CDKN2A WT1 CAMK2A LOX FOXO4 E2F4 MARCKSL1 MMP3 SRPK2 TBP NOTCH1 HTT HEL-S-44 SP1 JUNB MAPKAPK2 FOS IRS1 ATF3 MYOG PAICS AURKB MCM2 TCF20 ARID1A MAFK ATR BAD BCL2A1 CXCL1 BRAF PML GFPT1 KPNA2 HCFC1 KIFC1 ATM OPTN CEBPB CDK4 CDC2 IKZF1 JUN RBL2 HDAC1 KDM1A PDK4 RUNX1 FOXO3A NFKB1 RELA FOXA2 JAK1 PMC5388758__F5 Gene networks associated with intestinal processes and diseases POR C6 C7 HEL-S-62p AGER C2 C1S C9 PTEN C4B_2 RORA PMC11765784__F2 Mechanism of amino acid signal sensing in PCa RHEB GCN1 VWCE ATF4 PMC7035310__F3 Main anatomical connections—outputs and input pathways (shown as arrows) of the zona incerta SI DCN PMC4716033__F2 p21-activated kinase 4 signaling pathways in gastric cancer EGF TGFB1 HGF EGFR SMAD2 PAK4 MMP2 CCND1 CTNNB1 PMC7946393__F1 Membrane trafficking regulation of primary cilium assembly in intracellular pathway PACSIN2 CEP290 CEP164 EHD3 INTU RAB34 SNAP29 ARL13B PACSIN1 IFT172 TMEM67 LPA CEP128 KIFC1 IFT20 AHI-1 RAB35 CEP97 RAB23 EHD1 PMC2901320__F5 CXCR4 pathway is affected in CD34+ cells from CAD patients HRAS STAT3 CRK FYN VAV1 RHO CXCR4 RAC1 PMC7969034__F8 Working model of IFI16/p204 recognizing dsDNA to active downstream signaling pathway TBK1 IFI16 IRF3 PMC6928971__F2 Overview of hedgehog signaling pathway DHH SHH IHH SMO PMC7564905__F1 Signaling mechanisms mediating the actions of neurotrophins STAT3 BAX STAT1 BAD FOXO1 GSK3B MDM2 GRB2 MTOR MYC PMC8397941__F3 Mechanistic Insight into the Effects of Curcumin on Neuroinflammation-Driven Chronic Pain TF CX3CR1 TLR4 PMC4689171__F2 IRAK4 inhibition to shut down TLR signaling in autoimmunity and MyD88-dependent lymphomas BTK BCL10 CARD11 IRAK1 IRAK4 MYD88 PMC11280978__F1 Mechanism of action by which MNPs cause neurotoxicity BDNF PMC3157841__F1 Expression Level Drives the Pattern of Selective Constraints along the Insulin/Tor Signal Transduction Pathway in Caenorhabditis SGK1 PMC8692646__F1 mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication RHEB TSC2 TSC1 ULK1 TFEB PTEN PMC10862883__F5 Acceleration within PREs widely affects the Notch signaling pathway DVL1 DTX1 HEY2 DTX2 DTX3 CIRSR NUMB TLE2 CTBP2 MAML3 ADAM17 APH1B CTBP1 JAG2 LFNG MFNG NOTCH3 HDAC2 MAML2 HES1 NOTCH1 HES5 DVL2 TLE6 RBPJ RBPJL HDAC1 NCOR2 MAML1 ATXN1 DVL3 CREBBP EP300 SNW1 KAT2B PMC6328495__F1 The regulation of the mevalonate pathway and the role of mevalonate-derived metabolites in cell proliferation UBIAD1 HMGCR PMC6435658__F7 Illustration summarizes the molecular mechanism and signaling pathways underlying the effect of Dis on HCT-116 cells HDAC1 BAX FAS ID2 HDAC5 SETD2 TNF HDAC2 ID1 FADD PMC4819171__F2 Transcriptome sequencing reveals e-cigarette vapor and mainstream-smoke from tobacco cigarettes activate different gene expression profiles in human bronchial epithelial cells MAX ECSIT PIR CS GRB2 FLNA TRAF2 PMC7912927__F1 PI3-K/Akt/mTOR signaling cascade RHEB TSC2 RICTOR TSC1 HEL-S-28 PTEN MTOR PMC2866836__F1 Mitochondrial Ca2+ channels/transporters and role in mitochondrial function DCC MCU PMC8212145__F4 Causal interactions from proteomic profiles: Molecular data meet pathway knowledge MYB SHC1 PMAIP1 PISD LAMB1 KRT19 MAPK14 RB1 STARD7 IFNG TFF1 CD24 MHC2TA PRKCA FLT1 SRC CCR1 STAT2 NBN RPS6KA4 IRF7 PRTN3 TCF7L2 CDKN1A BRCA1 MAP3K7 GREB1 GFER ATR MMP14 LAMA1 PGR CXCL1 IKBKE PML MTOR TBX21 XBP1 PRKCB RARA FOXC1 ATM ELANE CAMK4 KCTD6 ABCA3 CCND1 CXADR FOXA1 CD40LG MMP9 PTGS2 KRAS PRF1 PRKDC INCENP HEL-S-102 EP300 RPS6KA3 HCTP4 LCK PMC5796233__F1 Tumor progression toward cancer metastasis FAS PTEN VCAM1 CTNNB1 PMC5796233__F2 Overview of anticancer properties of pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene; PS) FAS EGFR MUC1 PTEN MMP9 CTNNB1 PMC6821383__F1 Complement system and therapeutic targets in bacterial meningitis C6 C7 HEL-S-62p C2 C9 C4A C4B_2 CP PMC3259218__F1 Gemcitabine metabolic pathway genetic polymorphisms and response in non-small cell lung cancer patients CDA RRM1 RRM2 SLC29A1 RRM2B DCTD PMC3147552__F8 Schematic overview of IDO induction by H STAT1 STAT2 TLR4 IRF9 IRF3 JAK1 TYK2 MYD88 PMC3833059__F7 Scheme of the proposed LIF signaling pathway in trophoblasts TF STAT3 LIF SOCS3 GRB2 MTOR PMC7793792__F1 Regulatory mechanisms of ferroptosis TF IREB2 SIRT3 STEAP3 GPX4 GSK3B SLC7A11 ATG5 KDM3B PMC6543449__F2 IRFs in the TLR and IFN pathways IFNGR2 TIRAP TLR3 STAT2 IFNAR2 TLR4 IRF9 IRF2 TLR9 IRF1 IRF7 TLR7 PMC9685675__F6 Roux-en-Y gastric bypass-induced perturbative changes in microbial communities and metabolic pathways in rats PLB1 ASAH2 CERS1 DEGS2 KDSR PMC8226792__F4 Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins CDC42 TBK1 PIK3CA BAD RAF1 PLA2G10 BCL2L1 RALA FOXO4 CHUK RALBP1 ETS2 PLD2 TNFSF6 KSR1 ARHA PLCE1 EXOC2 TIAM1 SHOC2 AFDN RIN1 SOS2 RELA RRAS REL PMC3355325__F2 Two distinct DC semi-maturation pathways induce different types of regulatory T cells IL10 RELB CCR7 TNF CTNNB1 PMC6819419__F1 Necroptosis molecular pathway RIPK3 HMGB1 TRADD TLR3 MLKL TLR4 IL33 FADD PMC5295594__F2 Regulation of ecdysteroidogenesis TSC2 TSC1 SMAD2 PMC9289614__F1 Editorial: Autophagy-Mediated Cell Survival and Death in Disease Progression and Treatment ATG101 ATG3 ATG12 ULK1 ATG14 ATG5 PMC11016524__F2 Understanding PI3K/Akt/mTOR signaling in squamous cell carcinoma: mutated PIK3CA as an example TSC2 TSC1 CSH2 C2 PTEN PMC2430503__F1 Resistance to ErbB-targeted cancer therapeutics MTOR IRS1 PMC8212145__F5 Causal interactions from proteomic profiles: Molecular data meet pathway knowledge STAT3 BAD RAF1 SHC1 PGR AKT3 GSK3B PIK3R1 RPS6KA1 BRAF SMAD4 MAPK9 ACACA MTOR MAPK8 PRKAA1 MAPK3 PRKCB CTNNB1 MAPK14 FOXM1 WWTR1 PDPK1 PRKCA NRAS HEL-S-1 SRC CCNB1 CCND1 MAPK1 RPS6 JUN PTPN11 YBX1 ERBB3 ACACB TSC2 NRG1 RICTOR COL6A1 GSK3A FOXO3A RPS6KB1 CDKN1B RELA ERBB2 BCL2 LCK PMC9113527__F1 Enhancing HR Frequency for Precise Genome Editing in Plants RAD52 RAD51 PMC3163779__F1 Thyroid hormone action is modulated by the deiodinases TRH PMC6567815__F2 Synthesis and function of NAD+ in the cytoplasm and nucleus HEL-S-90n NAMPT NADSYN1 PMC6567815__F3 Synthesis, metabolic pathways and function of acetyl-CoA ACLY ACSS2 SIRT3 FAS HEL-S-162eP HEL-S-278 PC ACSS1 SIRT1 PMC11394240__F1 YAP/TAZ mechanisms in solid tumors, particularly HCCs, in hypoxic environments LATS1 LPA LATS2 RHO PMC11394240__F3 Phosphorylation of YAP/TAZ under hypoxic conditions LATS1 LPA BIRC5 LATS2 SIAH1 HMGCR IGF1R RHO PMC5711827__F1 Innate immune signaling pathways that drive type I IFN responses in mycobacteria-infected host cells TBK1 ESX1 CGAS TLR4 NOD2 IRF3 PMC5949009__F6 Schematic of accelerated tissue regeneration pathway via the dynamic and adaptive HMGB1–CXCL12–CXCR4–GAlert axis CXCL12 HMGB1 CXCR4 PMC5628280__F1 Signal transduction by flagellin in mammalian cells NLRC4 IL16 TLR4 TLR5 TRAF6 CCL20 IL1B PMC3130491__F4 Schematic of leptin intracellular signaling through the STAT3 and PI3K-PDE3B-cAMP pathways in the hypothalamus STAT3 PDE3B POMC NPY SOCS3 IRS1 PMC5933896__F3 Signaling and regulatory network of gp120 at apoptosis pathway ITGAM MAVS CX3CL1 FPR1 IL2RG BCL2 TERT FPR2 SLC1A2 NOX4 CD1D PMC7837452__F7 Iron-Sulfur Cluster Biogenesis, Trafficking, and Signaling: Roles for CGFS Glutaredoxins and BolA Proteins BOLA2B NUBP1 CIAPIN1 FES PCBP1 NDOR1 PMC7837452__F5 Iron-Sulfur Cluster Biogenesis, Trafficking, and Signaling: Roles for CGFS Glutaredoxins and BolA Proteins NFU1 PMC5381815__F2 TAM Receptor Tyrosine Kinases as Emerging Targets of Innate Immune Checkpoint Blockade for Cancer Therapy SOCS1 STAT1 SOCS3 PMC8207720__F3 Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma HNRNPL APC MMP2 EZH2 CXCR4 TUG1 USP47 SIRT1 CTNNB1 PMC2864432__F3 Insulin/IGF1 signalling pathways and AD BAD IGF1 IGF1R GRB2 SHE PMC9156618__F2 Bioinformatics approach reveals the critical role of the NOD-like receptor signaling pathway in COVID-19-associated multiple sclerosis syndrome CD40 PDCD1 CCL3 EPO HLA-DPB1 SLC6A19 CXCL8 PRKAA1 CTRL IFNG MME NLRP3 FLT4 F10 MAPK1 MEFV CSF2 CTSL AGTR1 PLG IL7R VEGFA FURIN CXCL10 HGS HLA-B ADAMTS13 ADAMTS2 HLA-A PYCARD TNFAIP3 IL2RA MTOR CS INS CSF3 MPO PSMD1 BTK REN PLAT F2 TLR4 F3 TLR7 ISG15 ACE2 FCGR3B VWF HMGB1 IL10 CD14 CD19 hEMMPRIN RBPJ HLA-DQB1 STS AGTR2 FCGR3A PRKAA2 CASP3 NCKIPSD NFE2L2 IL7 IFNB1 CYP3A4 PMC8209414__F2 Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis ACSS2 GOT2 HEL-S-133P CD36 F2 HK2 ASNS PRODH PMC4178909__F1 The role of the VHL elongin BC complex in the HIF1 pathway in normoxic, hypoxic, and pseudohypoxic conditions RBX1 CUL5 PFKL ELOC VHL PMC5180601__F6 Condition-specific dependency network (CDN) for indisulam for drug-sensitive cell lines EGLN1 JUN HEL-S-133P EDN1 ASPH EP300 HIF1A VEGFA EGLN3 CA9 CREB1 VHL PMC4545821__F5 2A-DNT on transcript expression, protein expression and nuclear signaling mapped onto the Kyoto Encyclopedia of Genes and Genomes (KEGG) peroxisome proliferator-activated receptor (PPAR) pathway UBC UCP1 HEL-S-28 PLTP ADA PMC4869267__F1 Scheme of glucose metabolism and the respiratory chain in Gluconobacter oxydans DSM2343 POLL PDC POLI PMC9157768__F7 Extracellular Vesicles From Stored Red Blood Cells Convey Heme and Induce Spic Expression on Human Monocytes SPIC BACH1 CX3CR1 TLR4 PMC8645845__F2 Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer ADM VLDLR TUG1 POU3F3 PMC11673387__F6 LTA causes mammary gland injury in dairy cows LTA FASN SREBF2 PIGS PTGS2 TNF PMC8233004__F5 Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin – A Promising Natural Lead for New Drug Discovery and Development IPP MVD MVK PMC9658666__F2 Pathways of Angiogenic and Inflammatory Cytokines in Multiple Myeloma: Role in Plasma Cell Clonal Expansion and Drug Resistance HGF DKK1 TNF IL1B PMC3924254__F7 A6 integrin is the upstream regulator of the IGF-1R signaling pathway that enables low levels of caspase-3 activation to signal lens epithelial cell differentiation initiation IGF1R SRC PMC8350499__F1 Acetylation in doxorubicin-induced cardiotoxicity STAT3 BAX IGF2BP1 STAT2 OPA1 IGF1R MTOR SIRT3 STAT1 IGF1 NLRP3 TINCR SIRT1 HDAC6 PMC6085989__F1 Proposed model of host signaling cascade in response to microbial signals to promote hematopoiesis STAT1 STAT2 TLR4 IRF9 DAP IRF3 NOD1 TRAF3 JAK1 TYK2 MYD88 PMC4767455__F1 Role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications DDB2 TSC2 DDB1 CUL4A CUL4B HEL-S-11 XPC PMC3678929__F2 Insulin-like growth factor 1 receptor (IGF-1R) signaling pathway TSC2 BAD TSC1 IGF1 ELL PTEN GRB2 MTOR IGF2 IRS1 PMC10512581__F1 Hippo signaling pathway and therapeutic targets LATS1 ACTR2 LATS2 CDK6 PMC8660125__F1 Regulation and Function of Interferon-Lambda (IFNλ) and Its Receptor in Asthma CDHR3 TLR3 TLR8 IRF1 IRF3 IRF7 TLR7 TRAF6 PMC9613570__F2 Non-pharmacological interventions for vascular health and the role of the endothelium KLF4 PIEZO1 KLF2 SRC PMC3678929__F1 The insulin receptor (IR) with its two subtypes IR-A and IR-B, the insulin growth factor 1 receptor (IGF-1R) and the hybrid receptors (IGF-1R/IR-A and IGF-1R/IR-B) IGF1 IGF1R IGF2 PMC5423118__F8 Graphic summary TK1 DCTD PMC3092277__F1 Hippo signaling network in mammals LATS1 RASSF6 LATS2 AMOT NF2 PMC6901313__F11 Conceptual framework of BCL-xL expression during persistent LPS senescence induction BAX NRAS PMC7153214__F6 The mechanism STAT3 PMC10307880__F2 Viral-mimicry response induced by DNMTis TES STAU1 TBK1 MAVS TLR3 IRF3 IRF7 PMC5414155__F7 Overall impact of ethanol stress on C PIG59 MALL GIP PMC11642419__F2 PRV evades the TLR and RLR signaling pathways TBK1 MAVS TLR3 TLR4 TLR9 TLR5 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC7838829__F2 Going, Toll-like receptors in skin inflammation and inflammatory diseases TIRAP TAB3 CD14 IRAK1 IRF3 TRAF3 TRAF6 MYD88 TLR3 TLR4 TLR8 TLR7 LBP PMC11642419__F3 PRV evades the DNA-sensing signaling pathway TBK1 CGAS UBE3C IFI16 IRF3 PMC5597247__F1 Transcriptional regulation of glycolytic and mitochondrial metabolism UCP2 STAT3 HEL-S-133P MEIS1 ENO1 HIF1A HEL-S-87p MYC PMC6470739__F2 Antioxidant signaling pathway regulated by quercetin BAX EGR1 KEAP1 MAF PMC11642419__F4 PRV evades the IFNAR–JAK–STAT signaling pathway ISG20 STAT2 IFNAR2 IRF9 EPO MX1 ISG15 TYK2 PMC12213685__F12 HDH-SBH drug pair act on potential targets and mechanisms of action of PI3K/AKT signaling pathway SYK BAD RBL2 PTEN CD19 MTOR RAC1 IRS1 EIF4E RHEB TSC2 TSC1 BCR CDC37 MDM2 GRB2 PMC8966870__F2 ILC2s can contribute to tumour rejection or tumour growth KLRG1 IL33 ARG1 CXCL2 CCL5 CXCL8 PMC4325629__F1 Hedgehog signaling in cancer stem cells: a focus on hematological cancers HHIP KIF7 PTCH2 SUFU PTCH1 SMO CCND1 GLI3 PMC4325629__F2 Hedgehog signaling in cancer stem cells: a focus on hematological cancers PTCH1 SMO CCND1 PMC7838032__F3 The cyclin D–CDK4/6 complex ATR CDK6 GSK3B CDK2 ATM CDK4 PMC2818223__F2 GSK3 regulation of STATs, Smads, Beta-catenin, and NFAT STAT3 LRP5 LRP6 CTNNB1 PMC8185945__F9A In Parkinson's patient-derived dopamine neurons, the triplication of Alpha-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition RASGRF1 CDC42 MAP3K10 SHC1 SOS1 VAV2 MAPKAPK3 MAPK9 MAPK8 MAPK3 MAPK14 PLCG1 DRD2 MAP2K6 SLC18A2 PDPK1 SRC MAPK1 GNAI1 JUN MAPKAPK2 RAC1 FOS MAPK10 MAP2K1 MAP2K2 GRB2 BDNF PMC9668345__F3 Alterations in the Salivary Proteome and N-Glycome of Sjögren’s Syndrome Patients KRT10 KRT2 HGF COL1A2 OSM LGALS3BP TNLG7A PML VEGFA PPP3CA NR3C1 STAT1 RORC NFKBIA PMC3393825__F1 Signaling the Mitochondrial Unfolded Protein Response HTRA2 CLPP NRF1 PMC6646234__F10 MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling BAX THY1 HES1 HES5 PMC2516358__F7 Time ordered sequential events control cellular decision of migration EGR1 HGF DHRS9 ERRFI1 PTGS2 AKAP12 FOS PMC3925720__F1 miR-22 in tumorigenesis PTEN MYC PMC7381748__F2 TPL2 signaling CD40 STAT3 JUN EGFR BPI CXCL1 GSK3B NFATC1 MMP9 COX2 MMP2 CXCR4 IL1B PMC7779757__F1 WNT pathaway signaling PORCN APC ZNRF3 GPR49 LEF1 DAAM1 CTNNB1 PMC3851544__F6 MT1G as a tumor suppressor in thyroid cancer cells through regulating the PI3K/Akt and Rb/E2F pathways.MT1G restoration inhibited phosphorylation of Akt, leading to inhibition of cell growth MT1G MDM2 PMC7751468__F6 Differentially expressed genes between normal mammary tissues and triple negative breast cancer tissues involved in PI3K/Akt signaling pathway based on the Kyoto Encyclopedia of Genes and Genomes analysis SYK MYB BAD BCR PI3 PTEN ME1 MDM2 RAC1 PMC9664868__F1 Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library PPCS PPCDC PMC1082717__F1 The mTOR pathway and the potential intersection with LMP2A-activated PI3-kinase/Akt signaling HIF1A MTOR MYC CCND1 EIF4E PMC5896702__F2 Biomarkers of resistance to immunotherapy CD80 APC MDM2 JAK1 LAG3 PMC11929342__F5 Nrf2 as a target in ovary and ovarian dysfunctions focusing on its antioxidant properties KEAP1 PMC12176563__F3 Multimodal regulation of cardiac metabolic flux and enzymatic hierarchy OGT NR1C1 BDH1 CD36 PMC12176563__F4 Metabolic-targeted therapeutic interventions for cardiac functional recovery HEL-S-62p DPP4 GIP SIRT1 IMPACT PMC8120183__F7 Cardamonin inhibits the progression of oesophageal cancer by inhibiting the PI3K/AKT signalling pathway CDH2 BAX BAD PDK2 APAF1 PMC7103699__F1 Schematic representation to highlight the possible mechanism of action by which adjuvants exert their adjuvanticity CGAS TIRAP AIM2 PMC4333386__F8 The functional interaction between RecQ helicases and the FA pathway RAD51 MRE11A BLM PMC11398426__F7 Regulation of STING expression by CBFB/RUNXIn basal conditions, CBFB acts as a rheostat to fine-tune cGAS-STING pathway activity TBK1 CGAS IRF3 VHL PMC7901659__F1 Prostaglandin-Endoperoxide Synthase 2 (PTGS2) in the Oviduct: Roles in Fertilization and Early Embryo Development COX1 COX2 PMC3144045__F1 Signal pathway activation by different surface PRRs SYK BCL10 MAL IRAK1 IRAK2 HFE SRC TRAF6 IRAK4 CARD9 MYD88 PMC3508273__F4 The role of tumor-associated macrophages (TAMs) during tumor angiogenesis IL10 FGF2 PMC5385204__F6 Genomic alterations in malignant melanoma MC1R ASIP NGFR AKT3 GSK3B BRAF TFAP2A EZH2 MTOR MYC KITLG GNAS NGF CREB3L2 BOK EP300 ATF4 HLA-B MDM2 PMC2783837__F2 TRAIL-R1/-R2 apoptotic signaling pathway FADD PMC6061042__F3 Tri-m-cresyl phosphate and PPAR/LXR interactions in seabream hepatocytes LPL FADS2 ME1 SET PMC4482087__F7 Rewired upstream transcription subnetwork in regulating the downstream pentose phosphate pathway in biomass conversion in Y-50049 yeast strain versus the wild-type NRG2 tal-1 FBP1 NOM1 RFX1 PMC7693814__F5 Illustration describing inflammation and apoptosis mechanisms in SARS-CoV-2 infection, suggesting similarity with those in Parkinson’s disease under oxidative stress TMPRSS2 STAT3 STAT1 PARP14 ACE2 TYK2 FADD PMC5167405__F8 Non-Canonical Role of IKKA in the Regulation of STAT1 Phosphorylation in Antiviral Signaling TBK1 STAT1 MAVS IRF3 IL6 JAK1 TYK2 PMC7554875__F1 NFKB and MAPK pathways SP2 IRAK1 TNF IRAK4 MYD88 PMC4066980__F4 Model for Id1 regulation of melanocyte growth and melanoma development NOP16 BRAF ID1 PMC5791865__F1 Impact of MK2- and IKK-dependent phosphorylation on RIPK1 function CASP8 RIPK1 FADD PMC7241659__F1 Cellular metabolism during T cells activation CD36 HIF1A MTOR MYC PMC8363725__F6 The biosynthesis of the nemamides PCP2 HEL-S-62p C2 PCP4 PMC12150591__F2 Oxidative stress plays a dual role in CRC development APC GSK3B CCND1 CTNNB1 PMC6469615__F2 Proposed metabolic pathway for shea butter biosynthesis adapted from Argout et al LPA GPAT4 PC PMC4482087__F6 Rewired transcription network regulating metabolic pathways for tolerant industrial yeast Saccharomyces cerevisiae NRRL Y-50049 NRG2 GAL OAF PMC12150591__F3 Differential regulation of oxidative stress and cell death by wild-type and mutant p53 UCP2 MDM2 MTOR NOX4 PMC12150591__F4 Oncogenic roles of KRAS and BRAF mutations in CRC development, malignant transformation, and metastasis PDPK1 GCLC BRAF PMC4610744__F1 Genes and pathways identified from GWAS and/or studies of monogenic allergy-related diseases STAT3 NFATC2 IL33 LRRC32 MYC IL6R RORA TGFBR1 TGFBR2 PLCG2 WAS IL2 FOXP3 LPP FOXA1 DOCK8 CDHR3 IL13 IKZF4 IL1RL1 DSG1 CDSN SPINK5 FLG OVOL1 GATA3 TSLP TLR1 IL2RB PGM3 PTGER4 KLF13 BCL6 TLR10 PMC7958998__F2 From genetics to pharmacological treatment.Notes: Bone morphogenetic protein receptor II, BMPR-II; BMP-responsive element, BRE; Caveolin-1, CAV1; 12-kDa FK506-binding protein, FKBP12 BMPR2 SMAD1 DKFZp781O1323 SMAD4 KCNK3 PMC6201690__F1 Overview scheme of the PD risk factor genes and the molecular pathway where they are involved SCARB2 COQ7 PINK1 LRRK2 HLA-DQA1 ALAS1 BST1 SNCA TMEM175 SMPD1 SLC17A5 VPS35 HEL-S-130P FBXO7 KAT8 MCCC1 PMC10152798__F5 HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway WNT4 PMC3464266__F3 Insights into Pancreatic Cancer Etiology from Pathway Analysis of Genome-Wide Association Study Data MAPK1 CHRM5 AKT3 F2RL3 GZMA NEUROG3 LPAR1 OR1C1 MYLK3 OR14A16 CHRNB3 OR10G3 OPRK1 OR10P1 CCKBR GABRG1 OR13C9 OR13F1 OR10C1 OR11A1 NMUR1 OR13A1 EDNRA OR13C3 PMC4390253__F1 Construction of the Golgi/endosome network (GEN) and of the IR subnetwork (IRGEN) KRT18 HEL107 HEL-S-273 ARCN1 PRKAA1 CTNNB1 APOA4 PRKCSH INSR AK2 CLU LNPEP HEL2 CRP LPL UBC CIC GNAT1 CAD ANXA2 CTH MIF HEL-S-70p PHB2 ACACB LAMP2 KIF5A GCS1 HEL-S-162eP FKBP2 PLVAP APOB HP GRB14 PIGR TPMT PMC8698340__F2 Peripheral Cytokine Levels as a Prognostic Indicator in Gastric Cancer: A Review of Existing Literature TIRAP PAK1 TLR4 GRB2 TRAF6 MYD88 PMC7940388__F6 Signaling pathway mediated by CBD in SH-SY5Y cells ULK1 TRPV1 MTOR ULK2 PMC3817717__F2 Ingenuity Pathway Analysis (Ingenuity Systems, Inc., Redwood City, CA) of endothelial gene expression LTBP1 ARHGAP1 SEC61A1 SMAD1 EPHA2 TP53BP2 THAP7 SERPINI1 IKBKE HIF1A MYC TRAF6 XBP1 ERN1 HEL-S-99n TPM1 PLAT PACRG ATP6V0C TPM3 WAS ATM HNRNPK FBLN2 DHPS JUN STAR ADM SP1 TFDP1 PLG EPHA4 ARHA FGF2 CEBPA ERAP1 DBN1 NAB2 ARHGAP8 SIRPA SERTAD1 TMOD2 AP1B1 BIRC2 SERPINB6 CDK9 DNAJC10 PMC8855225__F1 Gli Phosphorylation Code in Hedgehog Signal Transduction ADRBK1 GPR161 KIF7 SUFU SMO PCK1 CP PMC6660363__F2 Serum Proteomics Based Discovery Of Predictive Biomarkers Of Response To Androgen Deprivation Therapy In Advanced Prostate Cancer KRT1 STAT3 COMP TGFB1 MXD4 LEMD3 LPA AHSG APOA4 RPN2 ITIH3 AFP MUC5B HP HSD17B7 PIGR HBB PMC5660951__F7 Suggested mechanism of EtSCT action in CCl4-induced hepatic injury BAX SMAD2 MMP2 MMP9 PMC9127077__F1 C-Type Lectin Receptor Signaling in the Intestinal Microbiota-Inflammation-Cancer Axis SAP130 STAT3 SYK RAF1 AHR CXCL2 CARD9 CTNNB1 PMC8585084__F3 Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System SYVN1 ULK1 ATG14 TRAF6 ATG10 ATG3 USP15 ATG12 NEDD4 TRIM37 ATG5 SIRT1 TRIM65 NOTCH1 PMC4115639__F4 Cartoon depicts IL-15 mediated activation of the PI3K/ERK1/2 and JAK1/STAT3 pathways STAT3 IL2RB JAK1 IL15RA PMC3681701__F9 Sources of sphingolipids for the parasite RAB43 RAB30 RAB14 SMS tmp_locus_29 PMC4226052__F6 Up-regulation of the type I IFN canonical pathway by IFNB treatment STAT1 STAT2 PSMB8 IRF9 IFIT1 IFIT3 JAK1 TYK2 PMC8463267__F10 Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NFKB and RAS/RAF/MEK/ERK signaling pathway CDH2 CD44 PMC3822007__F1 New developments in the Induction and Antiviral Effectors of Type I Interferon TBK1 IRF3 TRAF3 CTNNB1 PMC6801420__F5 Pathway signaling network generated from the genes located within the top 100 most differentially methylated CpG islands FLT3 MLLT1 TTBK1 TNKS2 STK11 SHC1 DYRK1A GSK3B PAK4 ATF2 ARC ARHGAP32 DTNB GNAS NTF4 KLF16 ALK TEAD2 PRKCA SMO SH2B1 SRC DGKZ SHC3 MGMT JUN FRS2 APC VAV1 PTPN6 SKI YAP1 IRS1 TAF12 EIF4G1 CBL PCM1 TNKS CER1 EP300 RNF111 GAB2 PMC3925679__F2 Bile Acid Receptors in Non-alcoholic Fatty Liver Disease FGF8A PCSK9 LPL TG NR1C1 PDK4 ANGPTL3 VLDLR FGF21 LDLR PMC7670427__F3 EIF2 pathway overlay with the experimental data, AD detection and molecules activation prediction (MAP) ATF3 EIF2A CCND1 NOX4 PMC8015775__F11 Proposed model for a role of BANK1 in tolerant patients BLK SYK FAS BCR BANK1 TRAF6 DIABLO FADD PMC7946832__F1 Complement cascade and key canonical and non-canonical activities C2 CD46 MTOR PMC6517507__F1 Model suggesting the relationships between Th17, Th1* and cTh1 populations and their potential roles in post-vaccination immunity, LTBI and active TB CXCR3 IL16 CCR6 IL1B PMC6008051__F5 Network interactions of transcription factors predicted to be upstream of differentially expressed skeletal muscle genes MYLK2 RB1 MYOD1 GDF8 TNNC2 HIF1A VEGFA CTNNB1 SMARCA4 PMC4966488__F1 Viral oncolysis dependent on RNA-activated protein kinase (PKR) inactivation STAT3 EIF2A FADD PMC6356359__F6 Proposed epigenetic model of colonic inflammation and carcinogenesis associated with long-term exposure to a diet high in n-6 fatty acids (n-6HFD) APC CCND1 CTNNB1 PMC9629042__F2 Ultrasensitive chemiluminescent neuraminidase probe for rapid screening and identification of small-molecules with antiviral activity against influenza A virus in mammalian cells POR MAX PMC3631177__F2 Expression of Glyceraldehyde-3-Phosphate Dehydrogenase Associated Cell Cycle (GACC) Genes Correlates with Cancer Stage and Poor Survival in Patients with Solid Tumors FBP1 HEL-S-87p PMC8960167__F1 Application of Regulatory Cell Death in Cancer: Based on Targeted Therapy and Immunotherapy BAX FAS GSDMD MLKL DFNA5 TNF CYLD APAF1 PMC8960167__F2 Application of Regulatory Cell Death in Cancer: Based on Targeted Therapy and Immunotherapy GPX4 LPCAT3 FACL4 NFE2L2 ALOX15 SLC7A11 AIFM1 PARP1 PMC5964334__F6 Proposed model of an energy balance-responsive network associated with DNMT1 regulation, DNA methylation and transcriptional regulation of ERA and ERB STAT3 EGF IGF1 EGFR TLR9 IGF1R TNF IRS1 IL1B PMC4002811__F2 Peli1 mediates IKK activation by the TRIF-dependent TLR pathway TLR3 TLR4 IRAK1 IRF3 IRAK2 TRAF3 PELI3 TRAF6 PELI1 IRAK4 MYD88 PMC3268129__F1 Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins TTL GRAP RET PMC7869004__F6 Drug target prediction and repurposing“Waterdrop” diagrams showing drug-target TES GLS PPM2C SNAP25 MTOR PMC8664259__F7 Role of TAF7 in linking transcription and translation BRD4 TAF1 TAF7 TEF PMC5474130__F2 Oxysterols in human cancer OSBP ABCA1 ABCB1 PMC6645245__F11 Schematic diagram representing possible antifungal mechanism (a–e) of CIN and EUG in C IDI1 ERG ASPA PMC9329358__F1 Molecular mechanism of pyroptosis HMGB1 GSDMD GSDMC GZMA GSDMB DFNA5 TNF PMC4689482__F2 ARID1A mutation and anticancer agents on the PI3K/AKT pathway ARID1A BRAF PTEN MTOR KRAS PMC3494084__F4 Baculovirus infection impact on host cell metabolism MAL CS CIT PMC5902007__F1 The gut microbiota in health and MS FOXP3 PMC11638311__F4 Metabolic pathway of sphingolipids CERS3 CERS5 CERK SPTSSA CERS1 CERS2 DEGS1 DEGS2 SGPP2 SPTLC2 SPHK2 SGPP1 SPTLC1 PMC11531110__F8 Metabolic pathway analysis and metabolite-protein interaction networks in broiler chickens challenged with CP and its different toxin combinations HEL-S-53e IMPACT PMC11531110__F9 Integrated metabolic pathway network analysis in NE-affected jejunal tissues NOS2 ALDH18A1 P4HA2 PC CS ARG2 PMC10136970__F3 Pan-pathway inhibition EGF CDK6 EGFR GRB2 CDK4 PMC6678315__F2 Activation of c-Rel signaling by the canonical NFKB pathway in B cells CD40 BTK BCL10 BCR PLCG2 PMC8257365__F1 Dietary Antioxidants in p53-Mediated Cancer Chemoprevention and Tumor Suppression BAX PERP PMC5838194__F3 Gene ontology enrichment of relate 16 key genes to the PPI network of NAFLD rat after fat diet feeding is presented ACLY ALB MAPK1 ACACB ACACA SRC TNF INS DECR1 PMC10419059__F3 Wnt/Beta-catenin signalling pathway LRP4 DKK1 APC LRP5 LRP6 DKK2 SFRP1 CTNNB1 PMC10419059__F2 Insulin and IGF-1 signalling pathway IGF1 GSK3B IGF1R PMC7711884__F1 Graphic scheme of the genes involved in the adsorption, distribution, metabolism and excretion (ADME) of fluoropyrimidines CYP2A6 CES2 CES1 RRM1 RRM2 DPYD TYMS SLC22A7 CDA UCK1 TK1 SLC29A1 UCK2 ABCC3 DPYS UPP2 ABCC5 UMPS ABCG2 TYMP PMC3179949__F6 A schematic representation showing 17Beta-estradiol inhibition of uPA and MMP-9 expression, and cell motility via suppression of JNK1/2 pathway in human LoVo colon cancer cells TIMP3 TIMP1 NMB PMC6266080__F4 LPL pathway and associated proteins LPL ANGPTL4 ANGPTL3 SEL1L LMF1 GPIHBP1 PMC9511810__F2 Base excision repair accessory factors in senescence avoidance and resistance to treatments CUX2 FEN1 NF1 KEAP1 COX2 Nbla10317 PTEN SATB1 NOX4 PMC4370285__F8 Schematic model of EGFR stabilization by cigarette smoke EGF EGFR GRB2 PMC8174805__F1 Disparate roles of retinoid acid signaling molecules in kidney disease FABP5 LRAT PMC4381776__F1 One-carbon metabolism in the cytoplasm and nucleus TK1 DHFR MTR PMC4889059__F2 Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype PC MTOR PMC8961234__F4 Unraveling the regulation of sugar beet pulp utilization in the industrially relevant fungus Aspergillus niger ABRA PMC10523725__F7 Gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis SLC3A2 GPX4 SLC7A11 PMC2577794__F1 Uncovering cryptic genetic variation in C EGF EGFR ADAM10 GRB2 PMC6098952__F1 Schematic representation for the possible interaction of viral oncogene proteins with various levels of Wnt/Beta-catenin cell signaling cascade SIAH1 APC GSK3B LRP5 LRP6 SRC MYC CCND1 CTNNB1 PMC5901897__F2 MEK5-ERK5 Signaling in Cancer: Implications for Targeted Therapy STAT3 FOXO3A PML HIF1A FOS PMC5541270__F8 Proposed mechanistic scheme of MUC13 regulating NFKB activation, related to , , and MUC13 TRADD ATM TRAF6 PARP1 PMC12119701__F8 Possible mechanism underlying KCTD1-enhanced HCC progression KCTD1 MTOR PMC6082822__F1 Autoimmune Responses in Severe Asthma EPX CCL21 IL16 APC ELL CCL17 MPO PMC8375270__F1 When Viruses Cross Developmental Pathways SUFU DHH SHH IHH SMO PMC4946912__F7 Network of transcriptional regulation and ligand receptor signaling PHF20 ZFP3 STAT3 RNF32 ENO2 ASB13 CHAC1 TGOLN2 CXCL1 GNL2 TMEM33 RGS16 TMEFF2 MSI1 RHOD SCMH1 CREB1 ZFP36 GALNT1 EGR1 CHAF1B CD14 HEXIM1 BLNK IRF1 IRF2BPL AF1Q BARX1 BARD1 HOXD13 ELAVL1 MGP EGR2 BDNF GADD45A GDE1 PMC5226473__F1 CDK4/6 inhibition: the late harvest cycle begins RHEB TSC2 EGFR MTOR CDK4 PMC8375270__F2 When Viruses Cross Developmental Pathways NOTCH2 NOTCH3 NOTCH1 PMC10237620__F1 MTOR signaling pathway in cardiac aging MLST8 TSC2 PINK1 TSC1 SGK1 ULK1 RHO MTOR DEPTOR PMC4007103__F2 Biogenesis of Drosophila small regulatory RNAs AGO1 AGO2 DROSHA PMC128142__F1 Proposed biosynthetic pathway of GPI in the ER of P PIGA PIGB GIP PIGM PMC7713543__F2 SARS-CoV-2 Replication and Interaction with Host Cells(A) Simplified schematic of the viral replication cycle TMPRSS2 MAVS TLR3 TLR7 ACE2 PMC8375270__F5 When Viruses Cross Developmental Pathways HES2 HES3 DLL4 FZD7 IHH CTNNB1 EVC FBXW7 HES4 DKK1 SHH SMO HES1 HES5 PMC4147239__F1 MTOR signaling pathway RHEB TSC2 TSC1 PTEN IRS1 EIF4E PMC9436908__F2 Modulatory effect of high salt on immune cells and related diseases NLRC4 NLRP3 NFAT5 ARG1 IRF4 MTOR TNF PMC11979251__F2 Immunogenic cell death (ICD) induced by epigenetic modifiers of DNA methyltransferase, histone deacetylase and proteasome inhibitors HDAC3 TUSC2 HEL-S-99n HMGB1 ANXA1 CXCL10 XBP1 PMC5061805__F1 Fast action antidepressants activate mTOR EEF2K MTOR BDNF PMC11979251__F3 Molecular mechanisms of immunogenic cell death (ICD) related to reactive oxygen species (ROS) production and endoplasmic reticulum (ER) stress SP1 ATF4 PMC5061805__F2 Mechanisms involved in the delay of therapeutic response to classic antidepressants in MDD patients EEF2K MTOR BDNF PMC11979251__F6 Crosstalk between immunogenic cell death (ICD) and different intracellular signaling pathways of nuclear factor kappa-B (NFKB), stimulator of interferon genes (STING), and mitogen-activated protein kinase (MAPK) HEL-S-99n TBK1 HMGB1 IRF3 PMC4856820__F3 Schematic picture demonstrating the myogenesis pathway and the myogenic regulatory genes (highlight in red color) identified in beltfish muscle transcriptome PAX3 MYF5 PAX7 PMC3755473__F1 Plasma Cells For Hire: Prior Experience Required BACH2 PRDM1 MTOR PMC9363660__F1 Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation IFNG HEL-S-92n BCR PREB TNF PMC1316260__F6 Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway EGF PLCG1 SHE PMC7803547__F2 CD8+ T-cell metabolism in COVID-19 CD80 KEAP1 APC MTOR IL1B PMC4696838__F2 MSCs reduce a central profibrotic factor, TGFB1, using STC1 in bleomycin-induced pulmonary fibrosis UCP2 PI3 MTOR BLM PMC7666630__F4 Constructed ceRNA networks based on the selected vital genes related to the MAPK signaling pathway: (a) the circRNA-miRNA-mRNA network and (b) lncRNA-miRNA-mRNA network DUSP5 DUSP10 DUSP8 JUN GADD45G HEL-S-102 GADD45B BDNF DUSP2 FOS PMC3658475__F2 P53/MDM2 regulation BAX ATR FAS ATM MDM2 XPC PMC7784881__F1 CD5 and B lymphocyte responses: multifaceted effects through multitudes of pathways and channels SYK IL10 BCR PLCG2 CD5 LYN MTOR PMC2846071__F1 Prevention trumps treatment of antibody-mediated transplant rejection CD40 BCR HEL-S-62p PMC5642988__F1 Hippo pathway in intestinal regeneration and disease LATS1 LATS2 AMOT RHO YAP1 PMC4174460__F1 Seven FDA-approved agents for the treatment of kidney cancer targeting the von Hippel–Lindau (VHL) tumour suppressor pathway TGFA EGFR MTOR VHL PMC5642988__F4 Hippo pathway in intestinal regeneration and disease EGFR YAP1 PMC2276649__F8 GSK-3B Targets Cdc25A for Ubiquitin-Mediated Proteolysis and GSK-3B Inactivation Correlates with Cdc25A Overproduction in Human Cancers ATR GSK3B ATM PMC11975862__F7 Active ingredient–shared target–pathway network analysis REN SHBG MDM2 PMC5642988__F5 Hippo pathway in intestinal regeneration and disease LATS1 LATS2 YAP1 CTNNB1 PMC3565315__F1 Overview of the Hedgehog signaling pathway: a simplified model for Hh signaling in mammalian cells KIF7 SUFU SMO PMC5642988__F2 The Hippo pathway in intestinal regeneration and disease CCNE1 EGFR HEL70 PMC5638134__F6 Chloroformate Derivatization for Tracing the Fate of Amino Acids in Cells and Tissues by Multiple Stable Isotope Resolved Metabolomics (mSIRM) GLDC MTHFD2 PHGDH SHMT1 PSAT1 PMC5642988__F6 Hippo pathway in intestinal regeneration and disease LATS1 MOB1A LATS2 YAP1 PMC3565315__F2 Overview about currently tested Hedgehog pathway inhibitors and their mode of action KIF7 SUFU DHH SHH IHH SMO PMC8961445__F2 Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators? STAT3 SYK BCR TLR4 TLR9 HIF1A MYD88 PMC8433626__F5 Protein C-Mannosylation and C-Mannosyl Tryptophan in Chemical Biology and Medicine DPM2 DPM1 DPM3 PMC8611677__F5 Cortical Transcriptomic Alterations in Association With Appetitive Neuropeptides and Body Mass Index in Posttraumatic Stress Disorder HCRTR2 P2RY1 P2RY11 PIK3R5 RBMS1 SOX2 PHC2 SIX4 KIRREL1 NPY5R ERG DYNLT1 NPY4R WNT2B ADGRE2 ADGRE5 GPR68 S1PR3 SALL3 NMUR1 GALR2 HILPDA SRC CCR1 PMC10466072__F9 Schematic diagram LATS1 LATS2 CDK6 RASSF1 PTEN CDK4 PMC6826584__F5 Notch signaling pathway by ubiqutination upon binding of Jagged/Delta (JAG/DLL) ligands to the Notch receptor (N1); the endocytic system is activated in the ligand-bearing cell EGF ITCH LNX2 MIB1 NUMB FBXW7 MAML1 ADAM17 NEDD4 RNF8 MIB2 ADAM10 MDM2 DLL3 HES1 NOTCH1 PMC7150840__F1 Simplified scheme of the Wnt/Beta-catenin signaling pathway SOST APC GSK3B LRP5 LRP6 CTNNB1 PMC5552414__F7 Abl Kinase Regulation by BRAF/ERK and Cooperation with Akt in Melanoma STAT3 PTEN TWIST1 PMC7150840__F2 FGF23/Klotho interactions with the Wnt/Beta-catenin pathway in the bone, kidney, and heart FGFR1 CTNNB1 FGF23 PMC2843459__F11 Schematic diagram illustrating the proposed signaling pathway involved in LTA-induced cPLA2/COX-2–dependent airway inflammation LTA RAC1 MYD88 PMC9363660__F3 Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation IFNG TNF PMC6826584__F3 Wnt signaling pathway and its regulation by ubiquitination The canonical Wnt signaling pathway is triggered by Wnt ligand binding to the complex of its receptor, Frizzled, and co-receptors LRP5/6 SIAH1 RNF146 ITCH APC LRP5 MYC CTNNB1 KLHL12 SMURF1 RNF43 SIAH2 ZNRF3 SKP1 SMURF2 GPR49 CCND1 FGF18 PMC6826584__F4 TGFB signaling pathway and its regulation by ubiqutination TGFB released from the LTBP1 complex binds to TGFB receptor II (TGFBRII) and initiates transphosphorylation and activation of the associated TGFB receptor I (TGFBRI) LTBP1 ITCH SMAD2 FAF1 SMAD4 SKP2 MIXL1 WWP1 HGS SMURF1 MYCBP2 GSC SMURF2 PMC4145234__F1 Regulatory networks of miRNAs and PI3K/AKT pathway in controlling EMT and cancer stemness in human tumors including endometrial cancer EZH2 PTEN MTOR TWIST1 PMC8863680__F2 Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations TBK1 MAVS STAT2 IRF9 IRF3 JAK1 TYK2 PMC7272579__F5 KEGG database pathway hsa05200: pathways in cancer BAX CDK6 POLK CDK2 MDM2 CDK4 PMC9022632__F2 Biology and Clinical Relevance of HCMV-Associated Adaptive NK Cells SYK HLA-E TNF PMC6298254__F3 Protein-protein interaction map of the TNF-induced NFKB signal transduction pathway TRADD MAVS ULBP3 LNX2 DHFR AMOTL1 TRAF3 GOLGA3 SHARPIN TRAF4 MOXD1 STAT1 MINDY3 YOD1 GDI1 UMAD1 TXLNA RNF115 S1PR2 AMOT CCDC112 HEL-S-166mP CEP135 CCDC14 NCS1 MLF1 MKRN2 OPTN CYLD ACTG1 CETN3 CASP8 FZD7 PRIM1 TNF TROAP RAB11B MAP3K7IP1 TRIM25 OFD1 TRAF5 TRAF1 RAB9A TRAF2 NDNF FADD PMC3865046__F1 Proteasome-dependent degradation of replisome components regulates faithful DNA replication ATR RBX1 MRC1 ATRIP TIMELESS PCNA CDS1 SKP1 PMC12066772__F16 The mechanism by which Iso inhibits RANKL-induced osteoclastogenesis CTSK NFATC1 MMP9 TRAF6 PMC8775422__F4 Pathophysiology of Mild Hypercortisolism: From the Bench to the Bedside APC LRP5 LRP6 CTNNB1 PMC4766428__F2 Bacterial cellulose synthesis mechanism of facultative anaerobe Enterobacter sp. FY-07 FAS HEL-S-162eP PDC OTP PMC6298254__F1 Protein-protein interaction map of the TNF-induced NFKB signal transduction pathway SHARPIN MAP3K7IP1 CASP8 TRADD ITCH RNF11 OTULIN TNF CYLD TRAF2 FADD PMC10518103__F9 DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress HSP90AB1 STAT3 DSCC1 PMC4979363__F6 Proposed mechanism of Hb (and its oxidized species)-induced toxicity: Hb undergoes oxidation to higher oxidation states, such as HbFe3+ and HbFe4+ F2 TLR4 HP PMC2762009__F1 The Tripartite Glutamatergic Synapse in the Pathophysiology and Therapeutics of Mood Disorders HRAS PSD NACA PMC8468657__F3 Iterative Upgrading of Small Molecular Tyrosine Kinase Inhibitors for EGFR Mutation in NSCLC: Necessity and Perspective EGF EGFR PTEN MTOR PMC2849853__F5 Regulation of the Hypothalamic Thyrotropin Releasing Hormone (TRH) Neuron by Neuronal and Peripheral Inputs MC4R NPY ARC AgRP PMC3788099__F7 Association between Inflammatory Infiltrates and Isolated Monosomy 22/del(22q) in Meningiomas CD40 CD59 HLA-DOB CD69 HLA-DRB1 PTPRC HIF1A IL11RA MYD88 TREM2 IGF2R CD58 HLA-DRA CD74 TYROBP CD93 WAS MSR1 PRKCA TLR7 CCR1 FCGR2A IL1B HLA-DMB HLA-DQA1 APC CD14 TLR5 FCGR1A IL10RA IRF8 SEMA4D CD44 IL17RA HLA-DMA FCGR3A BCL2 LYN VCAM1 GAB2 CYBB PMC4747886__F4 Molecular mechanisms of survivin in tumorigenesis STAT3 SMAD2 SMAD4 MDM2 CDK4 CTNNB1 PMC7522266__F2 Bifidobacterium longum subsp HEL107 PMC9524955__F7 Study on the mechanism of warming yang and reducing turbidity decoction in the treatment of diabetic kidney disease based on network pharmacology TF EGR1 SELE FOXO1 SMAD2 SMAD4 PIN1 PMC7843730__F2 Mechanistic dissection of diabetic retinopathy using the protein-metabolite interactome PIK3CA PIK3R1 GRIK2 DLGAP1 CAMK2A CD9 MAPK12 LY6K PSCA IZUMO3 IZUMO2 IZUMO4 SPACA1 ATAD3C ADAM18 SPACA4 LY6H TEX101 LYPD4 TANC1 ARHGAP15 APC TMEM121 PLEKHA2 LRFN4 AREG LRFN1 TSSK2 ERBB3 LY6G6D CTNNA1 CDC42 UBE3A GRIA3 LYPD3 TGFA EGFR PTPN13 CTNNB1 LRFN2 LYPD2 ACP6 LYPD6B GRIA4 CACNG2 MYO6 ARHA RAC1 AKAP5 CAMK2D ERBB2 CAMK2G PMC7843730__F5 Mechanistic dissection of diabetic retinopathy using the protein-metabolite interactome POR GRAP WAS LYST BOK ChAT CSTA ADA PMC8258133__F2 Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells EBP PRDM16 MSC PMC3664143__F1 A Novel High-Throughput 1536-well Notch1 Gamma-Secretase AlphaLISA Assay ADAM17 MBP ADAM10 PMC8279913__F2 Current therapeutics against HCV MAVS TLR3 TRAF6 PMC9019414__F4 Network Pharmacology Approach for Uncovering the Antitumor Effects and Potential Mechanisms of the Sijunzi Decoction for the Treatment of Gastric Cancer ACHE BAX PPARG EGF JUN BAD SELE EGFR PTGS2 ACACA VEGFA IL6 TNF MAPK3 POR PLAT HMGCR HEL-S-130P AHR MMD IL1B PMC8396838__F5 Comparative Transcriptome Analysis Reveals bmo-miR-6497-3p Regulate Circadian Clock Genes during the Embryonic Diapause Induction Process in Bivoltine Silkworm CRY2 CRY1 DBT PMC6590462__F6 Japanese encephalitis virus (JEV) intracellular effect mechanism PAK4 XBP1 PMC7880553__F2 Figure 2.Metabolites in early adulthood are associated with the cardiovascular phenome and identify pathways central to CVD development HEL-S-62p PC CS PMC4373423__F10 Suggested model for RF effects and interactions in various mouse tissues NR1C1 TNF SIRT1 PMC1195968__F1 RSV binding and triggering of cellular responses TLR4 IRF3 MYD88 PMC6874141__F1 Ras signaling pathways RARA EGFR PMC9112062__F7 Endothelial AMPKA1/PRKAA1 exacerbates inflammation in HFD‐fed mice ACLY EP300 PRKAA1 PMC11825097__F8 LIPG regulates goat intramuscular preadipocyte lipid deposition through the PPARA signaling pathway TG FASN LIPG PMC7094317__F2 Cell polarity pathways are targeted by diverse human viruses.Interplay between the Scribble (SCRIB), PAR, and Crumbs (CRB) complexes is central to the control of cell polarity CDC42 FAT4 PATJ APC SCRIB HBZ PMC7763974__F4 Apoptosis induced by high levels of NO is mediated via activation of the extrinsic apoptosis pathway which involves the TNFR and Fas/Death Receptors BAX FAS TRADD TRAF6 TRAF2 FADD PMC2774076__F7 Current working model of the signaling pathway components (shaded areas) that are differentially regulated in C57 and CD-1 pup brain tissues and cultured NSCs under normoxic and hypoxic (Hx) conditions STAT3 HIF1A MTOR BDNF CXCR4 PMC9230939__F2 Dual Roles of Protein-Bound Solutes as Toxins and Signaling Molecules in Uremia EGFR AHR PMC6485344__F1 The Krebs cycle FH ACO2 OGDH CS PMC5066299__F35 S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway TF KEAP1 MMP9 IL1B PMC6020056__F1 Complement cascades HEL-S-62p C2 PMC3269021__F8 Interaction of TOR pathway members for the regulation of phagocytosis RHEB TSC2 PTEN PDK2 PMC4362528__F8 Human splicing code reveals new insights into the genetic determinants of disease PRPF19 NDRG2 LHX1 AGO1 PPP5C DMBT1 AP3B2 KCNH3 COL13A1 ARHGAP32 AK8 RPS8 NISCH CEP250 RPL19 RAB3GAP1 CDHR2 PSMC6 EIF3F CDC45 PCNT LARS2 CSPG4 PMC3143377__F2 Molecular Targeted Approaches in Mantle Cell lymphoma BAD GSK3B PTEN PMC6042708__F14 Radio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells PGAM1 PDHA1 PFKL PMC9488512__F3 Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis FGF9 SHH FGF10 PMC3143377__F3 Molecular Targeted Approaches in Mantle Cell lymphoma BTK BLNK MTOR PMC3195192__F2 VEGF-VEGFR signaling in lymphangiogenesis VEGFC VEGFD VEGFA PMC4151823__F9 WWOX At The Crossroads Of Cancer, Metabolic Syndrome Related Traits And CNS Pathologies SMURF1 WWOX SMAD4 SMURF2 RUNX2 PMC8249521__F3 Introducing the novel Cytoscape app TimeNexus to analyze time-series data using temporal MultiLayer Networks (tMLNs) HEL-S-92n CDC20 POLA2 RAD17 COCH POLE SCT SMC4 PMC5352450__F2 Next generation sequencing and its applications in HPVassociated cancers CASP8 LTBR KEAP1 EGFR PTEN B2M TRAF3 MYC CTNNB1 RB1 CDKN2A CDK6 FGFR1 TP63 NFE2L2 ERBB2 FGFR3 HLA-B BIRC2 HLA-A FADD PMC7063521__F1 Positive and negative regulators of hepcidin synthesis ERFE STAT3 BMP6 TFR2 BMP2 SMAD4 HFE TMPRSS6 HFE2 PMC4811695__F1 Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects RHEB MLST8 TSC2 GRB10 GSK3B TTI1 PTEN MTOR NOTCH2 NOTCH3 DEPTOR NOTCH1 PMC6927459__F12 The impact of PSC and tumor cells on immune cells in the pancreatic cancer stroma STAT3 CD80 CXCL12 CCL18 CCL22 TGFA PCNA SMAD2 SPARC TLR9 SMAD4 MTOR TGFBR1 IFNG POSTN ADAM17 COX2 IL2 MICB IL10 CCL11 HEL-S-133P IL13 IL4 MICA CTLA4 IL6 TIGIT SERPINE2 BCL2 ADAM10 PMC8648391__F1 Potential synthetic lethal strategy with PARP inhibitors: perspective on ‘Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP’ MDM2 SNRPA1 PMC2757632__F1 O-GlcNAc cycling: Implications for Neurodegenerative disorders OGA OGT TRAK1 NUP62 PMC533963__F11 Model illustrating the signaling pathway through which Brk participates in EGF-induced cell migration and invasion EGF EGFR CRKL RAC1 PMC6591840__F5 Potential mechanisms underlying EOC chemoresistance and the sensitizing effect of PI3K inhibition CDH2 HEL-S-53e CS MTOR PMC4811695__F3 Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects C6 RICTOR FOXC2 FGF21 TTI1 UCP1 MTOR DEPTOR PMC6927459__F10 The crosstalk between PSC and pancreatic cancer cells EGF THBS1 TGFB1 GLS CD36 ANXA6 HIF1A IGF1R ABCA1 CD44 SERPINE2 HEL-S-32 SLC1A2 PMC9466598__F1 The hedgehog signaling pathway in rheumatic diseases: An overview TRPM7 SUFU SMO ENPP1 PMC7232513__F2 Interplay between virus-induced cellular aggregates and inclusions ELF4 AGO2 ATF4 EIF2A PMC9634253__F2 Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer STAT3 PLK3 ATM MTOR PMC6223216__F1 Wnt signalling pathways APC LRP5 LRP6 RYK RHO PMC7383044__F1 Activated c-Mpl dimer leads to activation of multiple signaling pathways which promote proliferation and platelet production MPL GRB2 PMC6234444__F1 Induction of oxidative stress by a virus infection and genome replication KEAP1 NQO1 MAF PMC2784899__F7 Model to account for responsiveness to cAMP level in activation but not inactivation of eumelanin synthesis MC1R MGRN1 ASIP MB PMC11669278__F7 Interaction network among the key genes, enzymes, pathways, and metabolites AGXT2 GOT2 CAD PLD2 GPT2 GFPT1 AOC2 MAOA NAGS TPH1 AASDHPPT AARS2 PIG59 AGXT KLNA1 HEL-S-5 ChAT ASNS BCHE CHKA NADSYN1 PHOSPHO1 CHKB GPT PMC9259182__F6 Identification of molecular mechanisms underlying the therapeutic effects of Xintong granule in coronary artery disease by a network pharmacology and molecular docking approach TF SELE EDN1 CASP3 VCAM1 PMC5746547__F1 PFKFB3-driven glycolysis and the central role of FAO via CPT1a function in ECs (a) Schematic of PFKFB3 as a key regulator of the glycolytic activity in ECs and the angiogenic switch PROX1 F2 PMC8588021__F3 Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders KEAP1 NQO1 GCLC IL1B PMC5833380__F3 ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells HEL107 ENO2 GLS HEL-S-133P HK2 GCLM HEL-S-89n HEL-S-304 HEL-S-68p F2 HEL-S-162eP ENO1 PFKL PMC4917857__F3 Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis HMGCR EBP CYP11A1 SQLE SC5D DHCR24 DHCR7 FDFT1 HSD17B7 TM7SF2 PMC2820725__F4 Redox signaling responses in DCs and T cells during T cell activation CD80 LAT GRB2 LCK PMC4917857__F7 Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis CYP11A1 CYP7A1 CYP46A1 HSD17B7 CYP27A1 PMC4336945__F3 Roles of Microphthalmia Transcription Factor and pigmentation in melanoma POMC DCT TYRP1 PMC3558493__F8 ErbB2-Dependent Chemotaxis Requires Microtubule Capture and Stabilization Coordinated by Distinct Signaling Pathways CDC42 PAK1 APC ERBB2 ARHA RAC1 PMC2888582__F6 Proteomics-Based Systems Biology Modeling of Bovine Germinal Vesicle Stage Oocyte and Cumulus Cell Interaction VDAC3 HEL113 HEL-S-273 HSPG2 EPHA2 GNG5 HEL-S-62p EGFR SMAD2 VTN HIF1A ITGAV RAB21 CTNNB1 GNB1 HEL-S-99n IGF2R GNPNAT1 POSTN ACTA2 TFRC APOH CD9 TPM3 ITGA2 ALOX12 HEL-S-1 CCND1 CFL2 JUP PNN ANXA1 ARHA PROX2 LRPAP1 ACTR3 BCAP31 ACTN4 VANGL1 MYL12A VCAM1 GDF9 ACR PMC9257096__F15 KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway CDH2 KIFC3 CDK2 MTOR PMC5520463__F1 The serine synthesis pathway (SSP) diverges from glycolysis utilising the intermediate 3P-glycerate, which is converted by PHGDH, PSAT-1, and PSPH into serine and then glycine PHGDH PSAT1 KRAS PSPH PMC6168630__F1 PI3KD activation in B- and T-cells during class-switch recombination ZAP70 BCR LAT BLNK RAG2 UNG PTEN AID PMC9562258__F1 BRAF Inhibitors in Non-Small Cell Lung Cancer ARAF BRAF GRB2 KRAS PMC8139249__F1 Bone Cells Differentiation: How CFTR Mutations May Rule the Game of Stem Cells Commitment? HOXA2 SMAD1 SOX2 MSX2 PMC2875624__F1 Alterations in transforming growth factor beta signaling cause changes in chondrocyte differentiation and osteoarthritis development SMAD1 SMURF1 DKFZp781O1323 SMAD2 SMAD6 SMURF2 RUNX2 PMC4552299__F2 Transcriptomic Analysis and Meta-Analysis of Human Granulosa and Cumulus Cells CD48 CD80 CST7 HEL-S-62p KRT23 TNF STEAP4 NLRC4 NLRP1 OLFML2B SASH3 SLC43A2 AQP9 NFAM1 PROK2 RAB37 GNLY PMC4479532__F3 Activation of a B-cell and its regulation by miR-155 SYK BCR LYN PMC4190552__F1 Roles of leukotrienes and acetylation in the expression of pro-inflammatory mediators through the NFKB pathway LTB LTA KPG_011 RELB PMC2891887__F2 Lymphangiogenesis and Lymphatic Metastasis in Breast Cancer VEGFC CCL21 CCR7 VEGFA CXCR4 PMC4702319__F1 CagA mediates dysregulation of the Wnt/Beta-catenin signaling pathway APC GSK3B LRP6 TEF CTNNB1 PMC3526371__F1 NFKB activation in pathogenesis and therapy of cancer LTB EGFR RELA PTEN TRAF6 KRAS TRAF2 MYD88 PMC3674567__F4 Postulated model for regulation of large luteal cells of ruminants (left) and primates (right) STAR CYP11A1 PTGS2 PMC9398379__F2 Whiff of the future: functions of phenylalanine‐derived aroma compounds and advances in their industrial production CAD PMC7950231__F5 Induction of type I interferons and signalling leading to the innate immune response during SARS-CoV-2 infection and drug pair action site TBK1 STAT2 IRF9 IKBKE IRF3 TRAF3 OAS3 TRAF6 IKBKG MYD88 STAT1 IFNAR2 NFKB1 IKBKB IFNAR1 NFKBIA CHUK TREML4 MAP3K7 TLR7 JAK1 OAS1 TYK2 OAS2 PMC3720155__F2 Sketch of the relationship between IGF signalling, the PI3K pathway and androgen responses in the prostate IGF1 INPP4B PTEN IGF2 PMC8282456__F3 Recent Advances in Heterologous Synthesis Paving Way for Future Green-Modular Bioindustries: A Review With Special Reference to Isoflavonoids BAX HMFN0839 MTTP FOXO3A BMP2 MMP2 BCL2 MMP9 PMC7563527__F1 Versatile cross-talks of CAF with activated progenitor cells and HCC TGFB1 HGF SHH CCL2 PMC4522610__F1 Main extracellular stimuli and intracellular signaling pathways leading to astrocyte reactivity in ND TF STAT3 CNTF GFAP COX2 SOCS3 IL6 IL1B HEL-S-44 PMC10266770__F1 STAT2 deficiency and other inborn and acquired defects of type I IFN signaling result in susceptibility to viral infections STAT1 STAT2 JAK1 TYK2 PMC2944809__F5 Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli Virulence STAT3 TBK1 TLR4 A2M TNF MAP2K3 TRAF2 PMC4310697__F4 Toll-like receptor (TLR), nucleotide-binding oligomerization domain (NOD)-like receptor (NLR), and retinoic acid-inducible gene (RIG-I)-like receptor (RLR) signaling CSA2 SYK TIRAP IRF3 TRAF3 TRAF6 CARD9 MYD88 PMC4173780__F1 Strategies for the production of linear, primary alcohols CRP HBD AHR FADD PMC8490190__F2 Emerging Nondopaminergic Medications for Parkinson’s Disease: Focusing on A2A Receptor Antagonists and GLP1 Receptor Agonists FOXO1 GSK3B MTOR PMC5497827__F1 Summary of the canonical Th2 pathway and “new spins” on the pathways that lead to allergic inflammation SOCS1 IL25 TSLP IL13RA1 IL33 IL4 AHR DENND1B SOCS3 STUB1 PMC4057583__F10 Link between NFKBIA and EGFR pathway in Glioblastoma EGF EGFR NFKBIA PMC7992789__F3 Roles of miRNAs in modulating the autophagy process in human breast cancer NBR1 LAMP2 ATG10 TSC2 ATG3 TSC1 ATG16L1 ATG12 PML PTEN SQSTM1 ATG5 PMC8267830__F1 Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network TH TSC2 GRB10 GSK3B PTEN DEPTOR PMC6367540__F4 Figure illustrates the signal transduction cascades of TGF/BMP, Wnt, Hedgehog signaling pathway in the development of cranial sutures SMAD1 DKFZp781O1323 KIF7 PTCH1 DHH SHH IHH SMO CTNNB1 GLI3 PMC5869864__F3 mTORC1 as the main gateway to autophagy ATG101 ULK1 TFEB AMBRA1 PMC4643669__F1 Novel role of miR-33 in regulating of mitochondrial function TFAM ABCG1 HADHB PDK4 CROT NRF1 ABCA1 CPT1A SLC25A25 PMC5739091__F1 Rag GTPase-dependent amino acid signaling pathway upstream of mTORC1 RHEB CASTOR2 CASTOR1 SLC38A9 PMC3392447__F2 Routes of AMPAR trafficking GRIP1 PICK1 KIF1A PMC3081173__F4 Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology CDC42 SPRY2 VTN ARHA PMC8467578__F1 Looking at Alzheimer’s Disease Pathogenesis from the Nuclear Side TES APOE GSK3B APP ADAM10 SIRT1 PMC5223230__F1 A central role of Batf3 DCs and the STING pathway in orchestrating anti-tumor T cell responses CXCL9 BATF3 CCL4 CXCL10 PMC4074565__F1 Regulation of mTORC1 by amino acids NPRL2 GIP FLCN LAMTOR1 SEH1L FNIP1 MIOS WDR24 PMC9340325__F2 Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products NLRP3 IGF1 PTEN IL1B PMC7767850__F4 Immune escape through PD-1/PD-L1 pathway in B-cell malignancies IFNG CD80 APC B2M PMC6114981__F7 FABP5-mediated transcriptional controlling network of mitochondrial functions in PCa cells FH FABP5 ACO2 MFN2 PMC7767850__F3 PD-1/PD-L1/PD-L2 pathway hijacking in oncology IFNG CD80 GNAL PMC4364059__F2 TLR and NLR pathways ATG16L1 NOD2 IRAK1 IRAK2 NOD1 TRAF6 IRAK4 MYD88 PMC7053056__F1 Kynurenine pathway represents one of three routes for NAD+ production or recycling ART5 ART3 ART4 PARP6 SIRT7 NAPRT PARP4 PARP16 PARP15 PARP8 AFMID SIRT2 NMRK2 SIRT3 PARP12 PARP11 HAAO AADAT SIRT6 NMNAT3 PARP10 GOT2 ID2 PARG HEL-S-90n PARP14 KYNU NMNAT1 SIRT4 SIRT5 NAMPT NMNAT2 IDO2 NMRK1 SARM1 IDO1 NADK PARP3 NADK2 NADSYN1 SIRT1 PMC8267830__F2 Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network RICTOR GRB10 GSK3B PTEN DEPTOR PMC4364059__F3 The inflammasome pathway CARD8 NLRC4 NLRP3 IL16 PMC3817019__F1 How the VEGF-A signaling pathway is linked to its main biological functions.Notes: VEGF-A can bind VEGFR-2 dimer PLCG1 NRP1 NRP2 VEGFA PMC3817019__F2 EGFR pathway and its main downstream effectors, PI3K/AKT and KRAS/BRAF/MEK/MERK.Notes: Activated AKT and MEK/MERK can induce cancer cell proliferation and invasion EGFR BRAF KRAS PMC4831838__F4 Proteomic Characterization of Middle Ear Fluid Confirms Neutrophil Extracellular Traps as a Predominant Innate Immune Response in Chronic Otitis Media BPI HEL57 AZU1 DMBT1 LYZ BPIFA1 PRTN3 CTSG MPO ITGAM MUC2 HEL110 ELANE S100A9 PIGR PMC7962349__F6 Intervention of natural products from traditional Chinese medicine on the TME STAT3 TLR4 IRF3 PMC4380398__F7 Pik3ip1 Modulates Cardiac Hypertrophy by Inhibiting PI3K Pathway EEF2K PIK3IP1 IGF1 EEF2 MTOR PMC5955471__F9 Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1 BACH1 KEAP1 IRF3 PMC4926194__F2 Known host targets of phleboviral NSs proteins in retinoic acid-inducible gene 1 (RIG-I) signaling and type I IFN induction TBK1 MAVS TRIM25 IRF3 PMC6844227__F14 KEGG pathway annotations of the PI3K-Akt pathway in non-small cell lung cancer SYK EIF4B BAD RBL2 SP2 PTEN CD19 MTOR RAC1 IRS1 EIF4E RHEB TSC2 BCR RXRA CDC37 MDM2 GAB2 PMC9301867__F5 Whole-exome sequencing identified mutational profiles of urothelial carcinoma post kidney transplantation HSP90AB1 PIK3CA IKZF1 SIN3A EGFR PIK3R1 NTRK3 MTOR VEGFA CXCL8 HRAS RB1 CDKN2A CDKN1A FOXO1 CDKN1B HDAC5 MMP2 ERBB2 MAP2K1 CCND1 CP PMC4695847__F1 Functions of mono-ADP-ribosylating ARTD (ADP-ribosyltransferase diphtheria toxin-like) enzymes and of mono-ADP-ribosylating Sirtuins in signaling SIRT4 GSK3B IL4 AHR TOX SIRT6 PMC5593680__F1A Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials ACLY RHEB FAS TSC1 FOXO3A EGFR MTOR EIF4E PMC7039855__F1 Wnt signaling pathways ROR1 BCL9 JUN TNKS APC ROR2 GSK3B ARHA RAC1 PMC7039855__F2 Wnt/Beta-catenin signaling in DCs and tumors in driving immune suppression and immune evasion CD80 XCR1 LRP5 XCL1 CCR7 LRP6 CCL4 TCF4 FOXP3 MTOR IL1B CTNNB1 PMC3835153__F2 Cisplatin resistance.Notes: Cisplatin creates DNA adducts and activates the apoptotic pathway, thus killing rapidly dividing cells CASP3 ERBB2 ATP7B ATP7A PMC6386927__F6 THD on a crosstalk in Fzd/GSK3B/Beta-catenin/P62 axis APC GSK3B TCF4 CTNNB1 PMC11747375__F3 GA inhibited the proliferation and migration of VSMCs CDC42 CDC2 FAS KSR2 PTEN ARHA RAC1 PMC11747375__F1 Molecular targets and mechanism of action of GA in hyperlipidemia BAX PGC NOS2 BAD FAS CD36 UCP1 FABP4 TNF PMC11747375__F2 Inhibition of atherosclerotic lesions by GA CDC42 KSR2 POLDIP2 ARHA NOX4 PMC3327724__F1 Heroin metabolic pathway in humans UGT1A1 ACHE UGT2B7 PMC8822594__F3 New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer STAT3 KLF2 CUL4A ITGB4 LAMC2 MCL1 EZH2 LPP CCND1 MYD88 PMC6244246__F5 Integrated transcriptomics and metabolomics pathway diagrams LPA GNPAT DGKA LPCAT2 APOH HEL-S-5 CLPS CHKB PMC5555522__F3 Molecular Pathway in Thyroid Cancer TSHR BRAF PTEN MTOR PMC7571161__F4 IFN signaling and synthesis pathway RIGI MAVS TLR3 STAT2 IFNAR2 IRF9 IRF3 ACE2 TYK2 PMC3822617__F3 Multifunctionality of ARC in regulating apoptosis signalling BAX BAD FAS ARC FADD PMC7140698__F9 Effects of Dot1L inhibition in influenza virus infected cells DOT1L TBK1 MAVS TRIM25 IRF3 PMC8125073__F5 Oral Epithelial Cells Distinguish between Candida Species with High or Low Pathogenic Potential through MicroRNA Regulation RPS6 NOS2 HEL113 TGFA ADM ANK2 EIF4EBP1 HIF1A MTOR NCOA1 HEL-S-30 IGF2 EIF4E HMOX1 RBX1 KDM1A ADRA1B FOXP3 MDM2 CTGF ELOC CP PMC4327623__F2 The main signaling pathways involved in the neuroprotective action of GDNF on dopaminergic neurons GDNF CASP3 BCL2 RET PMC8125073__F7 Oral Epithelial Cells Distinguish between Candida Species with High or Low Pathogenic Potential through MicroRNA Regulation IL19 BAX REN ECE1 SMAD2 LEPR MAL LYN MIP PMC4926123__F7 Anti-tumor effect of Beta-glucan from Lentinus edodes and the underlying mechanism STAT3 BAX CASP9 PARP1 PMC4988449__F1 Schematic model depicting how ERK1/2 activity is transduced through the Shoc2 scaffold PPIC ERBIN SHOC2 SCRIB PMC8306148__F1 Identification and Characterization of Multiple Myeloma Stem Cell-Like Cells APC GSK3B MTOR PYGO1 RHEB BCL9 TSC2 KIF7 SUFU DISP1 SHH SMO GLI3 PMC8917804__F3 Cellular and humoral host immune responses to SARS-CoV-2 viral infection STAT1 MAVS TLR3 STAT2 IRF9 IRF3 IRF7 TLR7 CS ACE2 TYK2 MYD88 PMC4613517__F1 Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress RBX1 KEAP1 MAF PMC11195429__F2 CGAS-STING signaling pathway TRIM38 CGAS KAT5 TNF SENP7 TTLL6 ENPP1 PARP1 TTLL4 USP35 DNASE1L3 OTUD3 ZDHHC18 SENP2 TREX1 PMC11195429__F3 Antitumor therapies awake the cGAS-STING signaling to accelerate the antitumor immunity CXCL9 CASP9 CGAS SLC19A1 CXCL10 PMC10308384__F5 Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development AQP4 CD59 NPS TLR4 CD55 PMC5929409__F4A In vitro study on role of σB protein in avian reovirus pathogenesis P2RX7 BMPR2 NOS2 WNT3A ANXA2 S100A8 SMAD6 SP7 SMAD4 HIF1A DDR2 MMP9 RUNX2 FGF2 HDAC3 TGFBR2 SOX9 TLR4 BMP2 FGFR3 S100A9 FGF18 ELF3 FADD PMC9578963__F1 Orchestrated signaling by PI3KA and PTEN at the membrane interface RHEB TSC2 BAD TSC1 PI3 MAP4 PTEN MDM2 SNX27 PMC10308384__F9 Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development FOXJ1 TLR4 PMC5666046__F3 Prolonged mechanical loading beyond physiological levels on tenocytes, increases the expression of IL-1B and CCL2 FAS CCL2 IL1B PMC9396386__F6 Time-course transcriptome analyses of spleen in rainbow trout (Oncorhynchus mykiss) post-Flavobacterium psychrophilum infection CD14 CXCL10 MYC MYD88 CXCL11 LY96 GRAP NFKB1 PDC NFKBIA CHUK IL12B LBP PMC7610305__F1 Upregulated AspH activates the Notch signaling pathway CD44 CCND3 EPCAM PCNA ASPH RBPJ PMC406426__F1 What is the role of mTLR7 in the antiviral response? Many ssRNA viruses (including VSV and influenza viruses) engage host cell receptors that trigger endocytosis TBK1 TLR3 TLR9 IRF3 TRAF6 IRAK4 MYD88 PMC5677537__F1 Ethanol upregulates TNFA in Kupffle cells via the activation of multiple pathways Ethanol administration activates the TLR4 pathway, ROS production and complement activation to increase the expression of TNFA TBK1 EGR1 TIRAP HEL-S-62p TLR4 IRAK1 IRF3 TRAF6 MYD88 PMC4983472__F5 Intracellular and intercellular signaling and cellular dynamics in bone healing and bone remodeling SMAD1 DKFZp781O1323 SMAD2 BMP2 MSC PTH RUNX2 CTNNB1 PMC8446672__F1 Targeting the Interleukin-23/Interleukin-17 Inflammatory Pathway: Successes and Failures in the Treatment of Axial Spondyloarthritis STAT3 IRF4 IL23R TYK2 PMC5666046__F2 Effect of mechanical strain on tenocyte CCR2 PC CCL2 IL1B PMC3205681__F2 Post-translational modifications (PTMs) of transcription factors OGA OGT RHD SRI MAFA VILL PMC3993104__F2 Interplay between host and bacterial factors leads to tissue destruction, vascular leakage, and hyperinflammation in invasive GAS disease SAG HEL-S-162eP APC PLG PMC1327675__F3 Interactive map (pathway) of 46 genes/proteins created in PathwayAssist® from the list of transcripts up-regulated in the testes of ABP-transgenic mice PGR MYH6 HEL111 MYF5 LYZ MAP2 MYC KLK6 BTK MME NTF3 SHBG A2M CYBA ETS2 EGR1 CAD SLPI GDNF IL6 CLN3 CD44 ATF3 CFTR NFYC PMC6034133__F8 Inflammation leads through PGE/EP 3 signaling to HDAC5/MEF2‐dependent transcription in cardiac myocytes TIAM1 HDAC5 RAC1 PMC5017163__F1 Different strategies of metabolic regulation in cyanobacteria: from transcriptional to biochemical control HEL107 HPR GCA GPD1 PMC6406345__F3 Protein–protein interaction network of associated genes in the etiopathogenesis of ANCA-associated vasculitis CD226 HLA-DRB1 TLR9 HLA-DPB1 MICA HLA-DPA1 COL11A2 PRTN3 HLA-DQB1 PTPN22 HLA-DRA AGER RXRB PMC6739476__F7 Pathway map assigned for MAPKs signalling ST14 ROM1 CD24 YOD1 MALL MAL MIP PMC11195429__F1 cGAS-STING and cell death pathways RIPK3 BAX CASP9 TBK1 CGAS GSDMD ZBP1 NLRP3 MLKL CASP3 IRF3 TNF PMC11682996__F1 Mechanisms of IFI44L in human diseases RIPK3 BAX TBK1 TREM1 IFNAR2 IFNAR1 TLR7 PMC5381938__F1 Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy IFNG APC CTLA4 PMC9314331__F5 S6K functions in feedback regulation HDAC1 TSC2 TSC1 GSK3B IRS1 PMC6755182__F8 Ginsenoside Rb1 prevent the steroid-induced avascular necrosis of the femoral head through BMP-2 and VEGF signaling pathway RB1 BMP2 RUNX2 PMC9522762__F2 Liver kinase B1 in tumor progression through regulation of lipid metabolism ACLY CD36 FASN SIK3 SIK2 CRTC2 SRPK2 MTOR PMC3708584__F3 ‘ErbB signalling' and ‘TGFB pathway' in the canonical pathway EGF HBEGF JUN ERBB4 BTC NRG3 GSC NODAL GRB2 MTOR PITX2 NRG4 PMC4351296__F6 Mechanism of dynamics of the EGFR-NHERF1-NHE1 signaling axis and its role in PDAC growth and invasion.In control cells EGFR, NHERF1, and NHE1 are separate EGF NHERF1 EGFR PMC3212439__F5 Immunoproteasomes Regulate Lps-Induced Trif/Tram Signaling Pathway in Murine Macrophages STAT1 TLR4 IRF3 TRAF3 TRAF6 TNF MYD88 PMC4624194__F1 STAT3 Signaling in Polycystic Kidney Disease STAT3 EGF HGF SRC PMC8418613__F4 STRING pathway analysis of LM and LuM CD11b+ druggable proteomic targets STAT3 LAMA5 ATP2B1 HSPG2 MYH6 TUBB4B HEL-S-269 MGST1 ABCF2 HEL-S-97n TUBA1B DECR1 MPO HEL-S-99n PYGL H1-10 NID1 HSPD1 ALOX5 TTN ALOX15 COL4A1 ELANE ACTN1 ABCE1 PYGM HMGB1 PDIA4 COL1A2 PGLYRP1 LGALS3BP APOE PTPN1 PSMD7 LGALS9 MMP9 CREG1 LAMP2 ITGB1 HEL-S-125m GNS RPN1 SIRPA LAMB2 ADAM10 HP LYN CYBB PMC6269503__F1 Role of Hippo signaling in regulating immunity LATS1 CGAS CXCL1 IRF3 MYD88 PMC3946526__F6 The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer CYP26B1 LRAT CYP26A1 PMC8026967__F3 Beyond DNA repair and chromosome instability—Fanconi anaemia as a cellular senescence-associated syndrome RAD51 FANCM FANCL FANCA FANCC FANCB FANCE FANCG FANCD2 RAD51C FAAP24 RFWD3 PALB2 SLX4 PMC5911217__F7 BRD7 regulates the insulin signaling pathway by increasing phosphorylation of GSK3B MEA1 BRD7 GSK3B MTOR EIF4E PMC6600376__F2 Mitogen-activated protein kinase (MAPK) cascades in activated, myofibroblast-like hepatic stellate cells (HSC/MFs) CDC42 EGF JUN CAD PAX2 RHO PMC6600376__F3 Major phenotypic responses in activated, myofibroblast-like cells (HSC/MFs) as well as, more generally, in hepatic MFs TGFB1 TIMP1 PMC11076734__F4 PINs-mediated auxin transport regulation during salt stress SOS2 PIN4 PIN1 PMC6600376__F1 ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis IFNG TGFB1 HGF TGFA MMP12 MMP9 CXCR4 FGF2 PMC3638125__F2 Intracellular signaling pathways of GLP-1R in the pancreatic Beta-cell FOXO1 EGFR ATF4 CCND1 PMC3172156__F2 RLR signaling pathway showing RIG-I bound to ligand RNA and signaling downstream to IRF-3 and NF-kB to induce IFNA/B production from a virus-infected cell IRF3 TRAF3 JAK1 PMC8908406__F1 Dawn of precision medicine in diffuse-type gastric cancer HGF FRS2 SMAD2 GSK3B SMAD4 CPO ARHA GRB2 MTOR FGFR2 PMC6121065__F1 mBDNF/TrkB and proBDNF/p75NTRsignaling pathways regulate gamma-aminobutyric acid neurotransmission PTEN ARHA SHE PMC11089157__F4 Post-translational regulation of FOXK2 CAD FOXO3A ATM FOXK2 MTOR SIRT1 PMC11089157__F5 Emerging roles of FOXK2 in cancers and metabolic disorders REST SIN3A TXNIP BAP1 EZH2 FOXK2 VHL PMC4335356__F4 Spatio-temporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases FHL3 TAOK2 JUN HIRIP3 UBC PCNA HEL-S-90n CDIPT YPEL3 NGF INO80E DOC2A PAGR1 MVP CSNK2A1 APP PRRT2 CORO1A PPP4C HEL-S-87p PMC11089157__F3 Transcriptional regulation of FOXK2 EGF SOX9 EGFR FOXK2 PMC9513364__F3 Advances in surface modification of tantalum and porous tantalum for rapid osseointegration: A thematic review TGFBR2 BMPR2 SMAD1 DKFZp781O1323 BMP2 SP7 RUNX2 CTNNB1 TGFBR1 PMC2747343__F1 Ingenuity pathway analysis shows 17 genes from the 180 genes associated with the NF-E2-related factor-2 (NRF-2)-mediated oxidative stress response pathway HEL-S-22 JUN AOX1 PXN LOC51064 PROX1 DNAJC3 CCT7 FTL ATF4 HSPB8 HEL-S-165mP HEL-S-44 CP PMC11082402__F5 Riboflavin metabolic pathway FLAD1 HEL-S-10 PMC9357610__F5 Pirfenidone alleviates cardiac fibrosis induced by pressure overload via inhibiting TGF‐B1/Smad3 signalling pathway SMAD2 PMC5291771__F1 The signaling pathway of DDX41 in innate immunity TBK1 BTK DDX41 IRF3 TRIM21 PMC5528350__F1 miRNA deregulation in cancer RAN DGCR8 XPO5 AGO2 MYC DROSHA PMC7191850__F7 Graphical summary of MITF action as a potent antioxidant in RPE cells through regulating NRF2-dependant antioxidant signaling to protect the neural retina against oxidative stress-induced degeneration RPE GCLM GCLC MAF PMC10148080__F4 NAT10 as ac4C writer in diseases BAX CEP170 NAT10 CDK2 CCND1 CDK4 PMC4131779__F2 Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil TGFBR2 STAT3 FLI1 SP1 SMAD2 SMAD4 TGFBR1 PMC6144938__F3 Important steps in cholesterol synthesis and homeostasis ABCG1 CYP11A1 DHCR24 LDLR DHCR7 ABCA1 PMC3358533__F5 PPARA signaling canonical pathway in chronic arsenic-exposed lung epithelial cells HSP90AB1 DNAJB12 NR1C1 CITED2 DNAJB6 COX2 NR1C2 NR0B2 TRAF6 TRAF2 HTT PMC9284900__F8 METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner METTL3 DKK2 DROSHA CTNNB1 PMC4267524__F8 Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer HDAC1 INA PTEN PMC7694477__F1 Hereditary hemorrhagic telangiectasia (HHT) and the transforming growth factor beta (TGFB) signaling pathway in endothelial cells BMP10 BMPR2 ENG SMAD1 DKFZp781O1323 SMAD4 ID1 PMC4197858__F2 Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease HEL107 RPE RPIA SMS SRM PMC4197858__F3 Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease UBIAD1 HMGCR DHFR ARHA GLO1 PMC7286357__F8 Proposed mechanism by which Xbp1s promotes inflammation and injury in renal tubular cells during AKI in sepsis TLR4 CD14 TCF2 SOCS3 XBP1 LBP PMC3836044__F1 Canonical (Wnt/Beta-catenin) pathway PIGO DKK1 APC CTNNB1 PMC4504424__F2 Cytokines determined to be up-regulated in plasma collected from pancreatic adenocarcinoma patients IL4 IL17A IL6 CCL5 VEGFA S100A9 FGF2 PMC12106287__F1 Membrane receptor tyrosine kinases-linked anti-BC effects of flavonoids as modulators of the MAPK signaling pathway, highlighting their capacity to function as sensitizers in chemoresistant BC and/or as chemopreventive agents CDC42 ATF2 RHO PMC9476305__F5 Recent advances and limitations of mTOR inhibitors in the treatment of cancer RHEB TSC2 TSC1 PTEN IGF1R MTOR IRS1 EIF4E PMC6627216__F1 Synthetic lethality of PARP-inhibitors in HR-deficient tumors ATR BRCA1 CHEK2 ATM CCDC6 PMC9307349__F2 Active Compounds and Targets of Yuanzhi Powder in Treating Alzheimer's Disease and Its Relationship with Immune Infiltration Based on HPLC Fingerprint and Network Pharmacology PLK2 SLC1A3 CHRM1 SNCA TNF CCL2 FOS ITGAV IL6R SPP1 GABRG2 RB1 PIG59 MAP2K4 GABRA5 F3 NFKBIA BCL2 MAP2K1 ITGB5 GJA1 PMC4555184__F3 Stem cell mechanobiology: diverse lessons from bone marrow RHO LMNA PMC6359168__F3 Apoptosis induced by Endoplasmic Reticulum (ER) stress BCL2 ATF4 TRAF2 PMC3906332__F4 Reprogramming of non-genomic estrogen signaling by the stemness factor SOX2 enhances the tumor-initiating capacity of breast cancer cells INSR SOX2 MTOR PMC7255038__F3 Schematic diagram representing interplay between metabolism and epigenetics ME3 OGT ME2 ME1 SIRT1 SIRT6 PMC3575604__F1 Evolution and impact of subclonal mutations in chronic lymphocytic leukemia POR ATM PMC9405286__F1 Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review CDH2 STAT3 BAX EGFR SMAD2 SOX2 MTOR CTNNB1 MYD88 TFRC ATG3 FTL TLR4 ATM CCND1 CDK4 PMC9503837__F2 Histone acetylation dynamics in repair of DNA double-strand breaks ATM HMGN1 MDC1 PMC5037390__F6 Hypothetical mechanistic network derived from predicted upstream regulators for genes found to be differentially expression in chondrocytes in transition from monolayer to alginate bead cultures (redifferentiation) JUN EGR1 APOE HIF1A CXCL2 BHLHB2 FOS COL2A1 ATF3 SOX9 NFKBIA GPNMB NFE2L2 ATF4 PMC6710759__F1 Schematic KEGG map representations of signaling pathways involved in Alzheimer's disease (a), Parkinson's disease (b), and amyotrophic lateral sclerosis (c) LPL IDE CASP9 BAD CCS APOE GSK3B SNCA NEFL TNF NEF3 NEFH IMPA2 CASP3 APP APAF1 PMC9398942__F5 Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise PDE5A PMC7593920__F3 The HMGB1 signaling pathway HMGB1 SP1 SELE CP PMC8165220__F3 Rac1, A Potential Target for Tumor Therapy CDC42 BMPR2 JUN ROCK2 VAV2 NRP2 IQGAP1 RAC1 CTNNB1 SEMA3C PAK1 OIP5 PLS1 MMP2 ERBB2 RAB35 ARHGAP24 PMC3312932__F2 Regulation of the human catalytic subunit of telomerase (hTERT) CTCF SP1 INHBC E2F4 MNT SMAD4 TERT MDM2 MTOR IGF2 PMC6662580__F1 Hippo pathway RASSF6 TP53BP2 PATJ RASSF1 PTPA STK4 LATS1 MOB1A FRMD6 MOBKL1A LATS2 BTRC HIPK2 AMOT ANKRD17 HEL-S-1 ANKHD1 CSNK1A1 NF2 HEL2 TAOK1 WBP2 CRB3 WWC1 SCRIB AJUBA CTNNA1 PMC8978518__F9 Therapeutic potential of the human endogenous retroviral envelope protein HEMO: a pan‐cancer analysis TF APC LRP5 LRP6 MB AXIN2 CTNNB1 PMC2442833__F1 Metabolic network of oryza sativa L MAL GIP CIT PMC6585737__F1 Receptors and signaling pathways mainly contributing to anti‐inflammatory polarization of microglia SOCS1 STAT3 NGF AXL SOCS3 NOX4 PMC3996671__F1 Ras and autophagy in cancer development and therapy ULK1 MTOR ATG5 RAC1 PMC9471064__F4 Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets BAX FAS TRADD TRAF2 FADD PMC6585737__F3 Metabolic drugs and molecular pathways exploitable to drive microglia into a pro‐regenerative phenotype MOS ARG1 SIRT1 PMC9471064__F5 Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets ATG101 ATG3 ULK1 AMBRA1 ATG14 MTOR PMC2758611__F6 Schematic presentation of the proposed TGFB signaling alteration that promotes HNSCC in mice HRAS TGFBR2 SMAD2 SMAD4 PTEN TGFBR1 PMC4724815__F6 Long non‐coding RNA urothelial cancer‐associated 1 promotes bladder cancer cell migration and invasion by way of the hsa‐miR‐145–ZEB1/2–FSCN1 pathway CDH2 ZEB2 PMC3444139__F3 NFKB signaling pathway in ATL CD40 LTBR RELA RELB PMC8740004__F6 FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma HDAC3 FOXA1 CTNNB1 PMC4689294__F1 Wnt canonical and non-canonical pathways APC ROR2 GSK3B LRP5 LRP6 ARHA DAAM1 PMC4049685__F2 Colorectal cancer metastasis signaling pattern DVL1 EGF JUN BAD EGFR SMAD2 RHO MYC KRAS CDA COX2 E2F4 GRB2 UNK PMC6947613__F1 Molecules and pathways involved in the effect of statins on NO production by endothelial cells CRP RHO RAC1 PMC2834303__F9 PI3K-Akt pathway negatively regulates LPS signaling and gene expression in mouse macrophages by inhibiting the activation of MAPKs TF EGR1 PTEN ATF2 TNF PMC4568768__F1 FSH signaling FSHR PMC4022041__F3 Genes involved in the TGF beta signaling pathway after 5 days RBX1 THBS1 SMAD2 SMAD4 NODAL ARHA PMC4279731__F7 RBP-J acts as a master regulator that maintains the identity of the JG cell KLF4 SRI NFATC4 HEL-S-14 MYOCD FCAMR GATA6 CRIP1 PMC5992182__F6 RIP1 protects melanoma cells from apoptosis induced by BRAF/MEK inhibitors BRAF CYLD PMC8812234__F6 IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer CD44 AMER1 CTNNB1 PMC8082456__F1 Key Role of NAD+ in Anti-Tumor Immune Response: An Update CGAS PMC8481577__F6 TNF-Alpha Pathway Alternation Predicts Survival of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer CXCL9 HEL-S-92n CXCL10 TNF PMC3824101__F1 Mechanisms involved in type I IFN production and its receptor signaling TBK1 CGAS FAS MAVS STAT2 IRF9 TLR9 IRF3 IRF7 MYD88 STAT1 TLR3 TLR4 NOD2 TLR8 NOD1 TLR7 JAK1 TYK2 PMC8070209__F10 Pathway involved in the synthetic lethality of PARPi with combination of cisplatin on Twist knockdown CisR OC cells BAX CASP9 CASP3 PMC5058735__F9 Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation TP73 MYCL MYC PMC3754247__F2 Oncometabolites: linking altered metabolism with cancer FH ACO2 KEAP1 MAL PMC4939268__F1 Metabolites involved in Glycolysis and Amino Acid Metabolism are Altered in Short Children Born Small for Gestational Age LPL RPS6KA1 PRODH TNF PMC7471342__F1 Top 25 mRNA-hub genes in baseline analysis PPARG SHC1 ITCH EGFR RPS14 CTNNB1 RPS16 FYN RPS3 APP HNRNPK HEL2 PSMD4 FAT10 RPS6 JUN RPS2 RPLP0 HEL-S-28 TSG101 CDC34 PARP1 WWP1 RPL3 RPS20 CSK ERBB2 SKP1 RPL4 RPS9 PMC8810966__F12 Sex- and estrous-cycle dependent dorsal hippocampal phosphoproteomic changes induced by low-dose ketamine RAF1 C2 HEL-S-14 BRAF CREM SMO HEL-S-11 PMC9170928__F8 Chicken telomerase reverse transcriptase mediates LMH cell pyroptosis by regulating the nuclear factor-kappa B signaling pathway IFNG NLRP3 GSDMA IL1B PMC11994599__F9 Salvia miltiorrhiza Bunge root in the treatment of myocardial fibrosis: research progress and challenges BAX TLR4 NOX4 MYD88 PMC11687105__F1 M(6)A biological functions SOCS1 CXCL1 SOCS2 SOCS3 MTOR FOXM1 ABCC10 AAG1 ATG5 CCND1 FGF16 SOHLH1 NPNT FASN VIRMA SOX2 KIT YTHDF1 PABPC1 POLK YTHDF2 IL8RB CISH BDNF BHLHE41 PMC11994599__F7 Salvia miltiorrhiza Bunge root in the treatment of myocardial fibrosis: research progress and challenges SMAD9 SMAD1 DKFZp781O1323 SMAD2 SMAD4 MMP2 MMP9 PMC11687105__F2 Therapeutic potential of RNA m(6)A in lung cancer BRD4 DLGAP5 PINK1 UBE2C KEAP1 CDC6 FRAS1 SOCS2 PTEN SLC7A11 COL10A1 TNS1 MTOR RAC3 HOXA1 FOXM1 DCP2 FLT4 ALKBH5 WTAP PLOD2 IGF2BP2 CYLD FAM83D TRPM7 IGF2BP1 TIMP3 IGF2BP3 H2AX JUNB VIRMA EZH2 YTHDF1 AKR1C1 YTHDC2 ID3 MZF1 HNRNPA2B1 TK1 ATG12 AXIN1 METTL14 YTHDF2 DAPK2 METTL3 HNRNPC TWIST1 PMC3760860__F6 Organized Emergence of Multiple-Generations of Teeth in Snakes Is Dysregulated by Activation of Wnt/Beta-Catenin Signalling SOX2 GSK3B LEF1 PMC8173116__F2 Monochromatic Lighting During Incubation and Vaccination on the Splenic Transcriptome Profiles of Chicken PDIA2 CTRL C1QTNF6 TNF PMC7922079__F4 Targeting EPC expansion as a novel therapeutic strategy TPH1 GATA1 MTOR PMC8801576__F8 Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T Cells via Increasing IL-6 Secretion Through PI3K/AKT Pathway IFNG IL10 TGFB1 PMC12055897__F2 LncRNAs and IgA nephropathy: underlying molecular pathways and clinical applications JUN PTEN PMC12055897__F5 LncRNAs and IgA nephropathy: underlying molecular pathways and clinical applications EGF EGFR PTEN PMC4668540__F1 Sonic Hedgehog Pathway PTCH1 SHH SMO GLI3 PMC7075017__F1 Fanconi anemia pathway of DNA repair RAD52 RAD51 ID2 TRAIP FAN1 FANCA BLM PARP1 FANCD2 REV1 MRE11A DNA2 POLE PMC3998839__F1 mTORC1 is a component of mTOR that is directly inhibited by rapamycin and rapamycin derivatives like everolimus RHEB EEF2K EGF TSC2 EIF4B BAD TSC1 IGF1 BCL2 PTEN CCND1 EIF4E PMC7862491__F2 Expanding the role of proteasome homeostasis in Parkinson’s disease: beyond protein breakdown STAT1 KEAP1 IRF1 JAK1 NRF1 DDI2 PMC6382377__F1 Lymphopenia and DMTs for relapsing forms of MS HEL-S-171mP ELL DHODH PMC7999163__F2 Possible mechanisms through which the gut microbiota could affect the homeostatic and hedonic pathways PYY PC NPY ARC AgRP PMC8169406__F5 Strategies to restore NO bioactivity GC ACE2 PMC6352225__F6 Schematic illustration of the role of human papilloma virus (HPV) oncoproteins in the production of macrophage migration inhibitory factor (MIF) HEL-S-133P MIF MTOR PMC7354740__F1 Leptin action in granulosa cells GRB2 IRS1 PMC7261627__F2 New insights into progesterone receptor signaling in the endometrium required for embryo implantation SOX17 WNK1 GATA2 PGR FOXO1 EGFR BMP2 MUC1 SMO WNT4 HAND2 PMC8724833__F7 Schematic figure of the action of OASL in pulmonary viral infection CGAS MAVS TLR3 TLR9 OASL AHR IRF3 IRF7 TLR7 TRAF6 GATA3 MYD88 PMC12158553__F1 Cellular heterogeneity between OA patients and non-OA controls CD44 GDF10 CXCL12 GRP CYTL1 CD74 MIF IL8RB CD163 PROC TNF PMC6718311__F1 Pro-apoptotic JNK pathway is strictly restricted in neurons BAD BMF DUSP16 HRK PMC4685734__F5 Apoptotic cell recognition receptors and scavenger receptors ARHG MEGF10 VAV1 ARHA RAC1 PMC8935239__F9 Icariside II enhances cisplatin-induced apoptosis by promoting endoplasmic reticulum stress signalling in non-small cell lung cancer cells ATF4 EIF2A PMC4685734__F6 Apoptotic cell recognition receptors and scavenger receptors MEGF10 ABCA1 RAC1 PMC5335589__F5 The extrinsic pathway of the coagulation cascade was investigated in our study VWF TFPI IL1A PMC7010798__F7 Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway CDC42 SFRP5 PPARG JUN LRP5 PTK7 WNT9B ATF2 TNF RUNX3 SFRP1 CTNNB1 FZD4 RUNX1 DKK1 NLK PMC11487499__F2 SPOCK1 promotes cancer occurrence by inducing the PI3K/Akt signaling pathway (by Figdraw) PHGDH PSAT1 ATF4 PMC9548471__F1 Genetic backbone of ankylosing spondylitis: how knowledge of genetic susceptibility informs our understanding and management of disease SOCS1 STAT3 SOCS3 TYK2 PMC3572392__F4 Almost all Theileria annulata proteins involved in glycolysis and citric acid cycle were identified in the study FH OGDH HEL-S-68p HEL-S-162eP PC CS PMC5124549__F1 Redox Biology and the Interface Between Bioenergetics, Autophagy and Circadian Control of Metabolism TF OGT KDM3A PMC3984540__F6 S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment care mediated by Gi and Rac CDH2 MMP2 RHO PMC11988162__F1 Illustration of the MAPK (left) and JAK/STAT (right) signaling pathways CDC42 JUN PTPRC ATF2 RHO MYC PMC11274390__F1 Zn and Cu in the synapse under physiological and pathophysiological conditions: (A) Roles of Zn and Cu under normal physiological conditions MT3 APP ATP7A PMC6358740__F6 Facets of Theiler’s Murine Encephalomyelitis Virus-Induced Diseases: An Update TRADD TLR3 IRF3 IRF7 TLR7 TRAF3 EIF2A TRAF6 FADD MYD88 PMC3478307__F2 Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K PDPK1 TRAF6 IRAK4 MYD88 PMC9094075__F1 Drug resistance in targeted cancer therapies with RAF inhibitors EGF EGFR BRAF GRB2 PMC7282681__F2 Schisandra chinensis on Alzheimer's disease signaling pathway LPL IDE CASP9 DCC BAD CASP3 APOL1 APP TNF APAF1 FADD PMC3805993__F2 Novel KP/KISS1R signaling pathways in breast cancer cells lacking the estrogen receptor, ERA CDH2 EGFR IQGAP1 ARHA MMP9 PMC3104724__F2 This figure outlines the role of KLF10 protein as a target and as a regulator of the TGFBeta-Smad 2,3 signaling pathway SMAD2 SMAD4 KLF10 PMC8869601__F6 Potential Citrate Shunt in Erythrocytes of PKAN Patients Caused by Mutations in Pantothenate Kinase 2 ACLY HEL60 PANK2 L2HGDH HEL-S-26 PMC7268922__F3 Function pathway analysis between COPD and the two genes: CD38 and TNFRSF12A EGF HMGB1 TNFRSF12A TGFB1 IL13 IL6 ARHA TNF FGF2 MAPK14 IFNG TRPM2 FOXO3A CASP3 KL IL2 ERBB2 SIRT1 IL1B PMC3175639__F2 Clock-cancer connection in Non-Hodgkin’s Lymphoma: a genetic association study and pathway analysis of the circadian gene Cryptochrome 2 IFNG VEGFC CEACAM1 SAMD9 ZBTB32 TXNIP CEACAM6 IL6 PMAIP1 GBP1 PMC5559046__F3 Cooperation of 20HE, IS, and TOR signaling pathways in the regulation of fly larva growth and development RHEB TSC2 TSC1 ID2 SHD PTEN ND2 ID1 PMC6601021__F1 Activation of the UPR pathway in tumor cells RTCB ATF4 EIF2A PMC3657461__F3 PI3K/AKT signaling in prostate cancer CDH2 FKBP5 PTEN CCL2 PMC3657461__F4 The JAK/STAT signaling in prostate cancer STAT3 ATF3 BRCA1 IL6 PMC5767254__F1 myomiRs and muscle mass wasting and atrophy pathways TFRC IGF1 EIF4EBP1 EIF4E3 FOXO3A YY1 HTR2A MTOR TWIST1 CTNNB1 PMC3657461__F5 ERK and PI3K activation and their crosstalk HRAS JUN BAD PTEN GRB2 PMC5767254__F2 Exosomal microRNAs (miRNAs), proteins, and muscle mass wasting ATG12 FOXO3A IRAK1 TLR7 TRAF6 IRAK4 MYD88 PMC3657461__F6 TGFB/SMAD signaling pathway and its implication in prostate cancer BMP10 SMAD2 SMAD4 PMC3657461__F7 Wnt signaling and its implications in the development of prostate cancer APC GSK3B LRP5 LRP6 MYC CTNNB1 PMC8104964__F1 TLR4 signaling pathways TBK1 TIRAP TICAM2 CD14 IRF3 IRF7 TRAF3 TNF CXCL10 TRAF6 MYD88 TICAM1 TLR4 IFNB1 LBP PMC2729321__F3 Is NFKB a good target for cancer therapy? Hopes and pitfalls MLN RELA RELB TRAF5 TRAF3 TRAF6 CYLD TRAF2 PMC3264131__F1 Metabolic pathway of C HEL-S-162eP PC PMC4591954__F1 Therapeutic targeting of the canonical WNT pathway CD44 TNKS APC GSK3B GPR49 CTNNB1 PMC3657461__F1 Androgen receptor (AR) signaling in prostate cancer STAT3 EGF PTEN PMC5854649__F1 TLR4 signaling pathway ECSIT BTK MAP3K7IP1 TLR4 MAL CD14 IRAK2 TRAF6 IRAK4 IL1B MYD88 PMC7765557__F2 Leptin-induced signaling pathways STAT3 EGFR PTEN MTOR SOCS3 ARHA CTNNB1 FOXO1 ROCK1 POMC RS1 NPY GRB2 AgRP SRC PMC9530148__F3 Astrocytes in neuropathic pain STAT3 S1PR1 CNTF LIF CXCL1 MMP2 OLIG2 RGMA ARHA MMP9 CCL2 RAC1 PMC8351219__F4 Molecular mechanisms of action of Nutlins in neuroblastoma cells HIPK2 MDM2 PMC2597498__F2 TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway RHEB TSC2 RICTOR MTOR EIF4E PMC2597498__F4 TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway RHEB EIF4E PMC12104071__F2 Research on the role and mechanism of the PI3K/Akt/mTOR signalling pathway in osteoporosis RHEB PTEN PMC3810594__F1 Renin-angiotensin-aldosterone system and regulation of insulin signaling phosphorylation of docking protein insulin receptor substrate -1 (IRS-1) is the major converging point in insulin signaling MTOR IRS1 PMC6966713__F5 Linear ubiquitination and NFKB activation TRADD IRAK1 IRAK2 TNF TRAF6 IRAK4 MYD88 SHARPIN RIPK2 TLR4 NOD2 TRAF5 RIPK1 TRAF2 PMC6800142__F7 TGFB receptors activate Smad signaling and non-Smad signal transduction pathways SMAD2 SMAD4 TRAF6 PMC5672637__F10 Schematic diagram for the functional mechanism of Aster glehni extract ACLY TG FAS HMGCR IL6 PMC5668426__F7 AGEs-Cyr61-VEGF pathway observed in this study RPE STAT3 MMP2 PMC8817869__F7 Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTorc2/Akt Signaling FOXO1 PCK1 SIRT1 PMC11547603__F1 Activation of the components of the TGFB/Smad canonical signaling pathway initiates the fibrosis process by inducing transcription of the downstream fibrotic genes TGFBR2 TGFBR1 PMC11547603__F2 Activation of TGFB stimulates NFKB and MAPK signaling pathways with the subsequent activation of the Wnt/Beta-catenin pathway TGFBR2 TRAF4 TRAF6 TGFBR1 PMC6368618__F8 Decidual RANKL/RANK interaction promotes the residence and polarization of TGFB1-producing regulatory GD T cells CD80 FOXP3 PMC11547603__F3 Activation and interaction of both canonical Wnt signaling and non-canonical Wnt/TGFB SMAD2 APC PMC4879891__F1 Canonical Wnt signaling pathway APC LRP5 LRP6 TEF CTNNB1 PMC9141076__F3 An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis AHR NFATC1 CYP1A1 PMC11547603__F4 Interaction between non-canonical Wnt/Beta-catenin and TGFB/Smad signaling pathways to stimulate the fibrogenesis process and transcription of the downstream fibrotic genes WNT5B FZD8 SMAD2 CTNNB1 PMC11547603__F5 An overview of role of TGFB in the pathogenesis of intestinal fibrosis COL1A1 COL1A2 TIMP1 PTEN MMP9 MTOR PMC11555136__F5 Signaling pathway involved in the development of persistent bladder hyperalgesia HMGB1 TLR4 MIF MYD88 PMC2949659__F1 Tamoxifen metabolic pathway CYP2B6 CYP2C19 CYP3A4 PMC11175075__F1 Jasmonic Acid on Stress Response and Quality Formation in Vegetable Crops and Their Underlying Molecular Mechanisms MYB LOX MYC PMC5897904__F2 Genes mapped to the IL-6 pathway by IPA Software CRP MAP3K7IP1 MAPKAPK2 TRAF2 FOS PMC12066244__F7 Action of Osteo‐F in osteoarthritis MIA IL13 IL4 COL2A1 PMC3462935__F5 Schematic diagram depicting the potential interactions between EGF, S100A11, and Ca2+signaling pathway in human endometrial cell IL15 HEL-S-43 EGFR LIF PMC9658491__F4 Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 SMURF2 DLX5 RUNX2 TGFBR1 PMC9658491__F5 Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review APC GSK3B CTNNB1 PMC5359577__F10 Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells TRPM2 PARG HEL-S-11 PMC8618701__F5 Proteomic Characterization of Plasma Rich in Growth Factors and Undiluted Autologous Serum CDC42 TGFBI PKN1 GFAP CYFIP1 PARG RHO PMC2043401__F1 Schematic outline of fatty acid synthesis in apicomplexans LIPA FAS MAL CP PMC8627049__F7 Integrated DIA proteomics and lipidomics analysis on non-small cell lung cancer patients with TCM syndromes PCSK9 LPL TG HEL-S-128m ANGPTL3 LDLR PC PMC6237564__F7 Stimulation of autophagy by MAC in lung cancer cells TSC2 BNIP3 MTOR PMC5543726__F2 REV1 and DNA polymerase zeta in DNA interstrand crosslink repair RAD18 FANCD2 REV1 MSH2 PCNA POLK FAN1 SLX4 EME1 XPC PMC5542201__F3 Effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS) RHEB TSC2 BAD TSC1 PTEN PMC9549801__F1 Relationship Between Ferroptosis and Diseases TF SLC3A2 STEAP3 GPX4 LPCAT3 FACL4 SLC7A11 ADA PMC12105125__S1 Schematic diagram of this study PC IRF3 IL6 CXCL10 TNF PMC4779714__F4 Identification of compounds that modulate retinol signaling using a cell-based qHTS assay STAT3 SYK SRC PMC8418074__F4 Current Insights and Advancements in Head and Neck Cancer: Emerging Biomarkers and Therapeutics with Cues from Single Cell and 3D Model Omics Profiling STAT3 CD3D JUN KEAP1 KRT6C EGFR APC PTEN MTOR MYC RB1 CDKN2A KRT6B FBXW7 CREBBP ATM EP300 GRB2 NOTCH1 CDK4 PMC9134657__F2 New therapeutic targets in ovarian cancer through identifying significantly non-mutated genes TBR1 BRWD1 TRAPPC9 COPS5 TRPV6 SMARCA4 PMC7555718__F4 Osteoclasts and Microgravity TEC SYK BTK OSCAR NFATC1 PMC8946555__F1 Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer NTS ADK ADA PMC8914608__F2 Emerging Biomarkers Beyond Leukotrienes for the Management of Nonsteroidal Anti-inflammatory Drug (NSAID)-Exacerbated Respiratory Disease CD40 IL25 TSLP DPP10 IL13 IL33 IL4 IL6 PMC6827304__F5 DAMGO and morphine differentially assemble protein-interaction networks to control MOR spatiotemporal signaling JUP ADRBK1 CRKL DSG1 IQGAP1 RAC1 DSC1 PMC2749695__F4 Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target RHEB BMPR1A APC PTEN MDM2 MTOR MYC CCND1 CTNNB1 PMC2749695__F5 Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target RHEB PGC TSC2 BAD VASP RBL2 CFTR MDM2 MTOR MYC CTNNB1 PMC2575629__F3 Alternative pathway of NFKB activation CD40 LTBR TRAF3 REL PMC7750705__F1 Roles of MGO in modulating cell signaling pathways, host immunity, and antiviral activity BAX HK2 ELL PMC4784386__F4 Functional interaction network of the final set of 50 genes prioritized with the consensus strategy and 100 additional interacting genes PPARG SRP14 DBT PRPF8 PHC2 ORC1L ROBO1 SNRPF NCBP1 PYGL FYN DRD2 SNRPB CSNK2A1 AGL NRF1 SRP19 SRP54 GOT2 PYGB SNCA EZH2 MAGOH SET SNRNP200 RNF2 PDHX RPE SF3A2 MCM7 SHOC2 OGDH MCM3 MCM5 DLD CHMP1A NDUFS1 SNRPA1 TH NDUFA12 ERCC2 CDC6 SLC25A20 CBX4 TRPC1 SNRPC CS CHMP3 MNAT1 APP RCN2 NCBP2 DBF4 SNRPG SNRPA CIRBP GTF2E1 GTF2E2 SRP68 CHMP2A ORC3 ORC2 ESRRA NR1C1 DLAT NR2A1 CHMP4C RGS4 CHMP4B NDUFA2 PMC4784386__F5 Functional interaction network comprising gene sets prioritized by Limma and ML BAGE GDF8 DKFZp434N041 CHST3 IGSF1 TLL1 PBX1 ADGRB3 PEX3 BMI1 C1orf21 STAT1 DRD2 FOXO4 HLTF F8 MDH2 NNT MASP2 LMAN2 PNMT APC AGTR1 HEL103 RELN NRXN3 RPS29 FRY SCG2 CHGB RBM4 CDK14 SESN1 SPTAN1 NPPC IL15 SYT17 ZNF547 VBP1 PSG1 SCNN1A PPP2R5C CCNH SUMO3 PAP SLC18A2 POLG COPS4 SLC25A32 RPL7 VPS4B ABCB9 ACP2 LILRA1 ACTG1 HEL-S-101 GPR161 CIRBP GOLGA1 BANF1 NFYB ZFP37 SCN1B RBFOX2 RBL1 TMOD3 VRK3 CRYZL1 HECA MAGED1 HIGD1B FLJ13057 SCN3B RGS4 VAT1 SS18L2 CRIM1 P4HA1 SYT1 PSMG1 PCDHB8 RLBP1 GNGT1 BCAS2 SYNGR3 CDH19 SMPX CXXC1 SELPLG STX10 KERA PDE6C TPBG WDR11 PDCD2 CLK1 SPTLC2 MT1G PRELP ARL1 SMARCA4 OXCT1 P2RX7 BMPR2 ROR2 SIRT4 RUNX3 RAD21 PAICS ATG12 INSM1 FBLN5 HEL32 SHOC2 EN1 DLD PYROXD1 RBM3 RET STRAP TH ATR IMMT HEL20 E2F5 SMAP TLK1 PCDH8 QPCT INSR SNX4 CTDSP2 CACNB3 SYCP1 PPM1B RCN2 KCNJ2 PLOD1 ITGA7 PF4V1 KCNJ6 PTPRN2 CCNC ESRRA NRG1 PKD1 PDK4 MAGI1 CHEK1 AHSA1 MMD PMC3728089__F5 Cholinergic anti-inflammatory pathway STAT3 ERBB4 TLR4 PMC12229708__F7 Uterine stromal MEN1 regulates stromal decidualization and epithelial differentiation ME3 PRL DKK1 IGFBP1 HAND2 PMC5963742__F5 BPA increases downstream survival proteins and GPER while attenuating the growth inhibitory effects of EGFR inhibition HEL-S-162eP EGFR HEL-S-44 PMC5486049__F5 Scheme representing major factors of CWIP and the calcineurin signaling pathway CDC42 ROM1 PMC11618518__F4 Macrophages in organ fibrosis IL13RA1 SMAD2 CCR2 VTN CCL2 TNF IL1B PMC11618518__F1 Molecular mechanisms of tissue fibrosis C2 SMAD2 RELA IL33 SMAD4 RHO MTOR CTNNB1 PMC7461575__F4 Integrates stress response (ISR) in the context of muscular disorders ATF4 TIA1 PMC8632384__F9 Network Pharmacology-Based Study on Irritable Bowel Syndrome Prevention and Treatment Utilizing Shenling Baizhu Powder TRO HEL-S-11 TNF FADD PMC8708342__F2 Species-Specific Differences in Aryl Hydrocarbon Receptor Responses: How and Why? KLF6 AHR PMC5931110__F1 Immune activating and suppressive effects of DNA double-strand break (DSB) signalling ATR IRF1 ATM PMC9320222__F9 Ferrocene-containing nucleoside analogue targets DNA replication in pancreatic cancer cells HUS1 ATR RAD50 RAD51 RAD1 MRE11A BRCA1 RAD17 BRCA2 NBN ATM RPA1 PMC3632591__F7 RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats HEL-S-22 HEL164 PLN NRCAM GULP1 FAS MMP12 VLDLR MYBL2 HEL57 BRCA2 NEFL CCNA2 ACTA1 PLK1 ELAVL2 INHBA CCNE1 PRC1 BOK MDM2 SMC4 MYBL1 STAR NUF2 EHF NEF3 MAD2L1 SPP1 PTTG1 CDKN1A AURKB MCM3 CDKN1C PSAT1 MCM6 NSL1 PMC7471342__F2 Top 25 mRNA-hub genes in delta analysis HEL-S-101 AGAP2 APOE CCR2 EEF1G SNCA CCT4 TSG101 CRK HEL-S-162eP HEL-S-102 EEF2 APP FGA PMC3632591__F8 RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats PMCH HEL-S-22 PLN EGF INA CENPE SULF2 FADS1 THRA EZR MME PRC1 MMP2 APP SMC2 CDC2 GNAI1 PRRG4 STAR NUF2 ECT2 VEGFA XPC UGDH CFTR HCTP4 PMC8229605__F1 Molecular Perspective of Nanoparticle Mediated Therapeutic Targeting in Breast Cancer: An Odyssey of Endoplasmic Reticulum Unfolded Protein Response (UPRER) and Beyond ELF2 ATF4 PMC8623349__F7 Nutrigenomic Effect of Hydroxytyrosol in Vascular Endothelial Cells: A Transcriptomic Profile Analysis MAX PLN PRKD1 PTEN MYOCD ATF2 MYC CTNNB1 MAP2K6 MAP2K4 MYH7 HDAC2 MAP2K3 RCAN1 UNK JUN EIF4EBP1 LIF MAPKAPK2 ARHA TNF TSC2 CTF1 NPPA IGF1 IKBKB EDN1 MAPK7 MAP3K7 MAP2K5 NPPB CYBB PMC8623349__F6 Nutrigenomic Effect of Hydroxytyrosol in Vascular Endothelial Cells: A Transcriptomic Profile Analysis HEL-S-99n CANX EBP BCL2 AMFR XBP1 VCP TRAF2 PMC4777991__F1 Regulation of insulin-like growth factor signaling pathway by microRNAs in hepatocellular carcinoma IGF2R IGF2BP1 IGF2BP3 IGF1R IGF2BP2 PMC5818278__F2 Synthetic scheme of CS oligosaccharides using enzymes COMP PNP PMC5509150__F4 Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival CYP2C9 CYP2C8 CYP4F2 CYP4F8 PMC7026059__F5 Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway SUCLA2 CS HP PMC3310225__F10 Protein Kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development CREM WNT4 FGF8 PMC6600639__F1 Upon T-cell receptor (TCR) signaling, the protein arginine methyltransferase PRMT5 interacts with DUSP14 and induces its methylation on Arg17, Arg38, and Arg45 residues MAP3K7IP1 DUSP14 TRAF2 PMC8186314__F1 GLI1: A Therapeutic Target for Cancer SUFU BRAF SHH SMO KRAS PMC6903391__F3 Epigenetic changes induced by iAs AS3MT CTH HEL-S-61p PMC5812824__F2 Gonadotropin regulation by pulsatile GnRH: signaling and gene expression SKIL GNRHR FOS FSHB PMC11559183__F1 Regular neuregulin 4 (Nrg4)-erb-b2 receptor tyrosine kinase 4 (ErbB4) signaling pathway EGF ERBB4 NRG4 PMC7916440__F2 Simplified overview of major protective signaling pathways involved in RIPC, the reperfusion injury salvage (RISK) pathway, and the survivor activating factor enhancement (SAFE) pathway STAT3 BAX BAD GSK3B PMC9219813__F2 Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface S1PR1 S1PR3 S1PR2 RHO S1PR5 S1PR4 PMC5812824__F1 Gonadotropin regulation by pulsatile GnRH: signaling and gene expression LHB GNRHR SNURF PMC5063512__F6 Schematic showing the mechanism of IGFBP-2-mediated regulation of Beta-catenin pathway in glioma cells involving A5B1 integrin, FAK and GSK3B GSK3B MMP2 IGFBP2 CTNNB1 PMC10514503__F2 S1P maintains the intestinal intraepithelial EC barrier SPNS2 S1PR2 RHO S1PR5 S1PR4 PMC10514503__F3 S1P protects the intestinal barrier through multiple means STAT3 S1PR1 S1PR3 S1PR2 SPHK1 IL18 ARHA S1PR5 S1PR4 PMC7102936__F3 mTOR at the nexus of nutrition, growth, ageing and disease RHEB EGFR GSK3B FNIP2 FLCN PTEN GRB2 SESN2 CASTOR1 TNF SLC38A9 PMC9221318__F4 Hedgehog Morphogens Act as Growth Factors Critical to Pre- and Postnatal Cardiac Development and Maturation: How Primary Cilia Mediate Their Signal Transduction PTCH1 SMO ARHA MTOR SRC RAC1 GLI3 PMC9221318__F3 Hedgehog Morphogens Act as Growth Factors Critical to Pre- and Postnatal Cardiac Development and Maturation: How Primary Cilia Mediate Their Signal Transduction SMO GLI3 PMC9471064__F1 Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets CDC2 RIPK3 BAX ATR TRADD MLKL GPX4 RIPK1 MTOR TRAF2 FADD PMC9219426__F1 Mitochondrial DNA in dynamics of the immune response to COVID-19 TMPRSS2 TLR9 ACE2 MYD88 PMC7102936__F5 mTOR at the nexus of nutrition, growth, ageing and disease RHEB NF1 PC PTEN BDNF PMC6831883__F3 Timing Analysis and Its Results for the Citric Acid Cycle(A) Timing analysis CTRL NOG MAL CIT PMC6433665__F3 Common alterations in fluorosis‐proliferation and differentiation SMAD9 SMAD1 DKFZp781O1323 SMAD2 BMP4 CTNNB1 FGF2 PMC5166550__F9 Signal pathway of IGF-1 by exercise IGF1 MTOR PMC6315103__F1 ProQ-dependent changes in Salmonella-infected HeLa cells TUBA1A ATR RRAS PMC3623009__F1 Simplified scheme of the complement activation network CD59 FH HEL-S-62p C2 CLU CR2 CD46 CD55 C4B_2 CP PMC7466665__F3 Role of LPA on Hippo-YAP mediated osteogenesis, angiogenesis and osteoimmunology LATS1 LPA CXCL9 ANGPT1 IL16 ARG1 RUNX2 PMC9456385__F1 Reactive Oxygen Species and Long Non-Coding RNAs, an Unexpected Crossroad in Cancer Cells BAX KEAP1 ATM PTEN MDM2 MTOR TNF PMC9221389__F8 Integrated Analysis Reveals S100a8/a9 Regulates Autophagy and Apoptosis through the MAPK and PI3K-AKT Signaling Pathway in the Early Stage of Myocardial Infarction HEL-S-103 JUN EGFR AKT3 MAPKAPK2 CD14 MYC MAP3K14 NGF MAP3K8 AGER MAPK7 MAPK10 MAP2K2 RRAS2 PMC8770807__F1 Hypomethylating Agent-Based Combination Therapies to Treat Post-Hematopoietic Stem Cell Transplant Relapse of Acute Myeloid Leukemia IFNG FLT3 SYK FOXP3 PMC9221389__F9 Integrated Analysis Reveals S100a8/a9 Regulates Autophagy and Apoptosis through the MAPK and PI3K-AKT Signaling Pathway in the Early Stage of Myocardial Infarction CASP9 MAP3K1 TIRAP GIP RHO MYD88 PMC4456045__F3 Negative feedback cross talk between PI3KA/Akt and NFKB signaling pathway by a local brief stimulation of TLR9, a potent preconditioning tool for programming the subsequent responses to I/R injuries and stimulation by TLR2, TLR4, or TLR5 ligands TBK1 NFKBIA TLR9 CD14 IRF3 ATF2 TRAF3 TRAF6 PMC4456045__F1 All TLRs signal through the common MyD88-dependent pathway MAL MTOR MYD88 PMC7736343__F7 An autoregulatory feedback loop of miR-21/VMP1 is responsible for the abnormal expression of miR-21 in colorectal cancer cells STAT3 VMP1 TFEB PTEN PMC3036178__F1 Lymphotoxin and the immediate tumor necrosis factor (TNF) family LTBR RELB TRAF3 TNF TRAF2 PMC8883113__F6 Prognostic Value of the Developmental Gene FZD6 in Young Saudi Breast Cancer Patients: A Biomarkers Discovery and Cancer Inducers OncoScreen Approach APC LRP5 LRP6 CCND1 CTNNB1 PMC2882741__F1 Schematic view of the GSL metabolism pathways GATC SMS GLA PMC4045475__F1 MUC1: A Novel Metabolic Master Regulator TSC2 TSC1 CD36 MUC1 FAT1 TIGAR MDM2 GLS2 PMC9409325__F8 Tumor Necrosis Factor-Alpha-Induced C-C Motif Chemokine Ligand 20 Expression through TNF Receptor 1-Dependent Activation of EGFR/p38 MAPK and JNK1/2/FoxO1 or the NFKB Pathway in Human Cardiac Fibroblasts EGFR TNF CCL20 PMC4045475__F3 MUC1: A Novel Metabolic Master Regulator HEL-S-133P CD36 MUC1 FAT1 GLS2 GPX1 HEL-S-44 PMC11931058__F8 Distribution of key targets in the most relevant pathways MAX TF STAT3 TH EGF FAS EGR1 TRADD SELE CD14 TNF PIN1 FLNA MEF2C MMP2 NLK GCK TRAF2 CDK4 PMC3724940__F5 Transcriptomic Analysis of Insulin-Sensitive Tissues from Anti-Diabetic Drug Treated ZDF Rats, a T2DM Animal Model NDUFB8 NDUFB6 NDUFB2 CXCL12 IDH3B CHCHD4 CYC1 NDUFS8 NDUFA13 COX6A2 UQCRQ NDUFAB1 ENY2 NDUFS3 MRPS12 MRPL34 COX6A1 FUNDC2 SOX6 CHCHD2 HADHB CHCHD6 COX8A CHCHD10 ACTR8 NDUFS6 NDUFB7 UQCRH VPS72 CLIC4 ETFDH CXCL13 COX5A CCL19 COX7A2 IPO5 PMC4602285__F7 The role of miR-19b in the inhibition of endothelial cell apoptosis and its relationship with coronary artery disease CASP3 PTEN APAF1 PMC6278438__F4 pathway of miRNA processing to regulate mRNA decay DGCR8 AGO2 DROSHA MDC1 PMC8156356__F2 Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function STAT3 BAX RELA MTOR FADD PMC3135880__F5 Survival and proliferative effects of Dilong extract on RSC96 Schwann cell NGF GDNF IGF1 PCNA PLG HEL-S-11 IGF1R BDNF CCND1 PMC8046396__F2 PPI network of HT consists of 43 nodes, 234 edges, an average node degree of 17, and a high-confidence interaction (0.7; ) PPARG LEP PCNA NUMB CDKN2B INS MYC ITGAV CTNNB1 RB1 CDKN2A ADAM17 CCNE1 CCND2 E2F4 CCND1 HES1 ADIPOR1 ADIPOR2 APOE RBL2 IL6 TNF RBL1 ANGPTL4 IGF1 CDKN1A PRL CDKN1B RXRA CDKN1C PMC4417587__F1 Metabolic pathways associated with 5-HT INMT KYNU KMO AANAT ASMT AFMID DDC ALDH3A2 MAOA IDO2 TPH1 ALDH2 TDO2 IDO1 HAAO TPH2 AADAT PMC7359717__F1 Synthesis and release of ACh by tuft cells ACHE GNAT3 TRPM5 PLCB2 ChAT BCHE PMC4123572__F6 Putative inhibitory pathway of the Cp-BF-mediated anti-inflammatory response SYK TLR3 TLR4 SRC TRAF6 MYD88 PMC11009220__F2 Interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health TBK1 MAVS IRF3 IRF7 TLR7 TRAF6 ACE2 MYD88 PMC2828612__F1 Putative mechanism by which the UPS acts downstream of BDNF/TrkB signaling to ultimately regulate Alpha-synuclein aggregation FAS BDNF FADD PMC8834953__F3 Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives HMGB1 NLRP3 IL1B PMC8566112__F4 Peroxisomal biogenesis pathway PEX14 PEX19 PEX6 PEX5 PEX16 PEX10 PEX3 PEX12 PEX13 PMC8566112__F5 Peroxisomal Beta-oxidation pathway ACOX1 ABCD2 ABCD3 PMC8566112__F6 Ether lipid synthetic pathway LPA DHRS7B AGPS GNPAT FAR1 PMC8080614__F1 Glutamine metabolic pathways GLUD1 GOT2 GPT2 ASNS GLS2 HEL-S-26 CP PMC12102898__F5 Diverse E3 ligases participate in the modulation of multiple signaling pathways via the ubiquitination process, playing crucial roles in either immunological activation or immune evasion through specific mechanisms STAT3 TH NBR1 TBK1 TRIM32 CNOT4 PARP1 BCLAF1 TRIM21 CDK6 SPOP MARCHF3 CDK4 PMC12102898__F3 NFKB signaling pathway processes and associated ubiquitination CD40 LTBR TRADD ITCH RELB IRAK1 TRAF3 TRAF6 MYD88 PLCG1 BCL10 BCR PLCG2 TRAF5 GRAMD4 TRAF2 PMC5923348__F3 Intricate relationship between CD30 and AP-1 in Classical Hodgkin Lymphoma (CHL) and Anaplastic Large Cell Lymphoma (ALCL) BATF JUNB TRAF3 TRAF2 PMC5877576__F11 EGFR multimerization and signaling, illustrating how carbohydrate-binding proteins or carbohydrate-transferases can directly affect transmembrane receptor signal transduction EGF EGFR MUC1 PMC12102898__F4 HBV virus structure and related immune ubiquitination process involving HBx protein UHRF2 NEDD4 HMMR APC TRIM29 TRAF6 CTNNB1 PMC12102898__F1 PI3K/Akt and Ras/MAPK signaling pathway processes and associated ubiquitination RHEB FBXW7 SPOP TSC1 NEDD4 BRCA1 TRIM71 PTEN GRB2 TRAF6 PMC12102898__F2 Wnt/Beta-catenin signaling pathway processes and associated ubiquitination RNF146 RNF43 APC AXIN1 TRIM65 CTNNB1 PMC6566956__F2A Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells ELF2 ATF4 EIF2A PMC8978805__F2 Impact of anti-inflammatory agents on oncogenic pathways DNMT3B STAT3 TET2 CXCL12 COX1 TET1 MCL1 GSK3B EZH2 MTOR SETD2 MYC YAP1 CIP2A TSLP COX2 CXCR4 CREB1 CRLF2 IL12RB1 PMC7904157__F5 SlKLUH expression is associated with genes involved in ‘Cutin synthesis and transport’ pathway HEL-S-15 PMC10458925__F1 EGFR/PI3K/AKT/mTOR signaling pathway RHEB TSC2 TSC1 EGFR PTEN DEPTOR PMC5551366__F12 Mitogen-activated protein kinase signaling pathway MAX ECSIT MOS NF1 CD14 NLK TNF FLNA PMC3534167__F2 Hodgkin lymphoma CD40 TNFAIP3 RELB NFKBIA NFKBIE REL CYLD PMC8509779__F1 Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways TH STAT3 CD80 APC VCAM1 TNF ACE2 PMC8080614__F5 Glutamine oncometabolites and energy production from glutamine TG GOT2 FH KEAP1 HEL-S-32 MDH2 HEL-S-26 PMC10367567__F1 CXCL12-CXCR4/CXCR7 signaling pathway CXCL12 BAD APC CXCR4 CTNNB1 PMC7792119__F9 Schematic diagram for the functions and mechanism of linc00887 in regulation of cervical cancer LATS1 FRMD6 LATS2 PMC3995293__F5 Oxidative Stress-Associated Protein Tyrosine Kinases and Phosphatases in Fanconi Anemia IFNG STAT1 ATR ATM PMC3209293__F6 IA30-infected pigs fail to induce immune response genes associated with pattern recognition of viruses and cytokine and immune cell responses in the lung CD40 SYK LCP2 TNLG7A JAK3 IFIH1 KLRK1 BLNK PIK3AP1 IGF1R IRF7 TNF CXCL10 MYD88 BTK TYROBP FCER1G TLR8 IFNB1 PSME2 GBP2 CCR1 PMC4620423__F1 Core signaling pathways in embryonic stem cells and cancer stem cells CDC2 STAT3 SMAD1 DKFZp781O1323 SMAD2 LIF APC SMAD4 NODAL FOS CTNNB1 BMI1 SUFU PTCH1 SMO PMC8481630__F7 BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NFKB Signaling Pathway Through Targeting TRAF2 TRADD TRAF2 FADD BRCC3 PMC12108521__F1 Molecular mechanisms of ferroptosis and key regulatory pathways STEAP3 GPX4 LPCAT3 FACL4 PMC3180440__F2 Regulation of the early myogenic transcriptional program by the kinome CDC2 CDK6 FOXO1 CDK2 GIP CDK4 PMC3180440__F3 Regulation of the late myogenic transcriptional program by the kinome CDH2 NFATC3 PDK2 MTOR CDK9 CTNNB1 PMC5620322__F1 PRAS40 signaling in tumor RHEB TSC2 PIM1 IRS1 PMC6018527__F1 Sema4D/Plexin-B1 signaling SEMA4D PLCG1 ROCK2 LIMK1 ROCK1 GSK3B ERBB2 RRAS ARHA RND1 RAC1 PMC4871423__F6 Integrated and Functional Genomics Analysis Validates the Relevance of the Nuclear Variant ErbB380kDa in Prostate Cancer Progression CXCR3 GATA2 SIN3A PPIG MAP3K14 RUNX2 CCND1 MXI1 PMC6636438__F2 Schematic model of ROS-activated signaling involved in the rapid modulation of NGB levels, its localization, and function on the redox balance outside mitochondria HMOX1 GCLM NQO1 NGB PMC5582379__F3 Five enriched pathways and their contributing DEGs are shown RFC4 RFC2 CDC20 PCNA RCC2 DHFR CENPE TYMS MYC SKP2 GINS4 CENPO CENPK E2F3 SMC2 AUP1 POLE LIN9 SMC4 GINS3 CDK4 CENPL CENPF SKA2 UBC NUF2 CENPN RBL2 SPC25 MCM7 POLA2 GINS2 CDK2 CENPA RFC3 PMC6032286__F1 Neuromuscular junction and congenital myasthenic syndromes ACHE MUSK PREPL LRP4 ALG2 GFPT1 DPAGT1 COL13A1 COLQ VAMP1 SYT2 ChAT ALG14 PMC7038066__F2 Proposed model of NO-dependent protein–protein interactions underlying GluA1 and GluA2 subunits’ trafficking CDK5 ARC BDNF PMC12245701__F2 TGFB inhibitors: the future for prevention and treatment of liver fibrosis? RHO MTOR PMC5084677__F8 Proposed model for the accumulation of BRCA1 complexes at DSB sites BARD1 BRCA1 RNF168 RNF8 RIF1 PMC4137413__F2 Genetics of Pulmonary Arterial Hypertension BMPR2 EIF2AK4 KCNK3 PMC9294386__F2 HIF-1A in Osteoarthritis: From Pathogenesis to Therapeutic Implications HMOX1 SOX9 BMP2 EPO BNIP3 PMC11103679__F1 Direct and indirect mechanisms of androgen signalling TF SRC PMC5486002__F1 The human 42 Kb INK4-ARF (CDKN2A/B) locus (not to scale) and its participation in two pathways controlling cell-cycling and differentiation CDK6 MDM2 CDK4 PMC4620694__F1 Graphical summary: DNA repair proteins such as DNA-PKcs can be targeted to improve outcomes for patients with ovarian cancer FANCF BAD EMSY RAD51 BRCA1 PARP2 PARP1 PMC5486002__F5 Examples of two pathways of histone modification by polycomb complexes leading to suppression of selected TSG SFRP5 DNMT3B BMI1 DKK3 ATR RBBP4 DKK1 PRC1 ATM DKK2 CDK4 CTNNB1 PMC5564844__F1 Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer EGFR GRB2 PMC9662188__F2 Caspase-2–dependent activation of de novo lipogenesis IL17RC CYP7A1 FASN DHCR24 LDLR DHCR7 PMC3460930__F1 Lovastatin Induces Multiple Stress Pathways ATF3 TSC2 EGFR ATF4 MTOR EIF2A CCND1 PMC9502459__F1 Do or Die: HPV E5, E6 and E7 in Cell Death Evasion BAX BAD FAS TRADD TRAF2 PMC4344846__F2A IQGAPs choreograph cellular signaling from the membrane to the nucleus RAN APC GSK3B LRP5 ZNRF3 IQGAP1 LRP6 PMC5000066__F9 Proposed model illustrating how KLHL21 modulates the NFKB signaling pathway via targeting IKKB KLHL21 TNFAIP3 CXCL1 IL1B NFKBIZ PMC5747948__F9 Comprehensive molecular biomarker identification in breast cancer brain metastases UGCG UFC1 CRTC3 MLXIPL RPL36 NDUFS4 COXFA4 COXFA4L3 FUNDC2 LSM3 CSNK2A2 PHLPP2 HEL-S-66 MYL12B RPL22 RPL27A TAF1D TMEM223 MRPL40 RPL31 PNN C3orf60 SLC19A2 CPA3 GTF2H2C_2 MRPS24 PCDHB14 CWC15 TUBG1 HAUS2 BANF1 HAUS1 HEL-S-34 ARMCX3 FKBP3 RPL23A RPL13A PLRG1 SLC25A6 PRSS23 APLP1 CCNK PMC5747948__F6 Comprehensive molecular biomarker identification in breast cancer brain metastases RASGRF1 RAP1GAP DDT KNOP1 CDON PLK2 GSDMB RPLP2 BLM MICU3 CCNG1 LLGL2 TTK SRC CENPU RRAGD RPS2 SPRY4 DMBT1 UBE2S GPR26 S100A7A EXOSC4 KNL1 ESRP2 NUSAP1 SMARCA1 EID1 LRCH2 PFKP CEP72 DHRS3 PMC6650613__F1 Schematic representation of the steroidogenesis pathway CORT CYP17A1 EPGN PMC5747948__F7 Merged network based on eight upstream regulators, of which E2f, ERBB2, IL6, HGF, and RABL6 were in a predicted activation state (z-score > 2) and let-7, TP53, and CDKN2A were in a predicted inhibition state (z-score < - 2) KIF15 BRIP1 RFC4 WASF3 PLK2 CKS2 BNIP3 ORC1L RARRES2 BLM H1-0 CDCP1 CDKN2A CCNG1 KIF24 PPFIBP1 ZNF655 TTK WDR76 CEBPB PCLAF NR1i1 LRP8 S100A7 RAD51 KITLG NR3C1 DRAM1 CCNE2 ANGPTL4 NUSAP1 LY86 DTYMK RABL6 C5orf22 POLR3GL SSPN ERBB2 GJA1 PMC5097364__F4 T3-actions from genomic and non-genomic effects on cell adhesion and differentiation during vertebrate development STAT1 APC RAC1 CTNNB1 PMC5747948__F5 Top canonical pathway is entitled, role of BRCA1 in DNA damage response BARD1 TOPBP1 ATR ATRIP MSH2 NBAS ATM MDC1 PMC11976366__F6 Quercetin inhibits gefitinib-activated cell death in NSCLC via regulating SHP2/ROS/AMPK/XBP-1/DJ-1 signaling pathway-mediated mitochondrial autophagy CGAS NLRP3 IRF3 PMC5097364__F2 Signaling pathways involved in cell-cell adhesion mediated by E-cadherin in physiological and pathological conditions KIFC3 APC RHO STS CTNNB1 OTP CP PMC7246474__F2 Summary of proposed pathogenic mechanisms in TRAPS TRADD TRAF5 RIPK1 TNF TRAF2 PMC8899988__F8 Novel HDAC11 inhibitor potentiates the tumoricidal effects of cordycepin against malignant peripheral nerve sheath tumor through the Hippo signaling pathway SP1 KIF18A TUBA1B PMC3747576__F6 Urokinase pathway model PLAT PLG PMC3825115__F1 Notch pathway effects on cytoskeletal plasticity TH TUB NUMB PMC11881735__F7 Epigenetic regulation of NFKB and JAK/STAT signaling pathway in SAH HDAC3 KLF4 STAT3 IL10 EZH2 SOCS3 VCAM1 TRAF6 MYD88 PMC5564844__F4 Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer STAT3 EGFR PTEN PMC8919722__F8 PRR-Mediated Immune Response and Intestinal Flora Profile in Soybean Meal-Induced Enteritis of Pearl Gentian Groupers, Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂ CXCL1 DAP CCL2 TNF UNK PMC12139130__F2 An overview of mechanisms of how gut microbiota increases the efficiency of immunotherapies IFNG CGAS TLR4 TLR9 IRF7 RGMB MTOR PMC11837068__F7 Schematic diagram illustrating that lncRNA H19 positively regulates S1PR3 expression by disrupting HDAC2/H3K27ac binding in EPCs S1PR3 HDAC2 PMC12139130__F1 Gut microbiota modulation in cancer metabolic reprogramming BAD RELA TIGAR FFAR2 PMC7432326__F1 Mode of 70-kDa heat shock protein (Hsp70) action inside and outside the cell BCR TLR4 APC FOXP3 PMC2174913__F2 Checkpoints activated upon rereplication CDC2 FANCD2 ATR ATRIP BRCA1 RAD17 CDK2 ATM PMC3308137__F2 miRNAs that promote or inhibit tumorigenesis provide diverse functions within oncogenic and tumor suppressor signaling pathways SPRY2 CCNE2 LIN28B CARD10 CCND2 PTEN CDC27 MYC KRAS SPRY1 PMC9354928__F11 Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma ARAF CDKN2A STAT1 NF1 BRAF GRB2 PMC7998272__F3 Alternate splicing of the LOXL2 mRNA LOXL2 HIF1A SRC PMC4098619__F1 Schematic diagram representation of some of the pathways regulated by HNF1a PCBD1 PDX1 SLC2A2 CREBBP PCBD2 CTNNB1 PMC5653694__F1 Circadian rhythms are driven by a vast network of oscillators regulated by multiple interconnected feedback loops that, in turn, synchronize the entire organism REST ARC MPO PMC2989866__F2 The Regulation of the CNS Innate Immune Response Is Vital for the Restoration of Tissue Homeostasis (Repair) after Acute Brain Injury: A Brief Review CD59 FH HEL-S-62p CR1 PMC8051073__F4 Ingenuity Pathway Analysis (IPA), prediction network of the T1DM conditions presented in this study with the upregulation (red) of miR-126-5p, IL-7, TNFA, VEGF-C, CXCR1, CXCR2 and glucose CCL27 VEGFC CXCR1 CELA2A IL8RB PMC4165197__F4 Action of recombinant bovine somatotropin (rBST) IGF1 GRB2 SHE PMC6966813__F3 Ubiquitination on mTOR signal affects the cross-talk between RAS-RAF-MEK and PI3K-AKT-mTOR pathways RHEB TSC2 FBXW7 RICTOR PDK2 MTOR TRAF6 PMC2728430__F1 How ERK1/2 Activation Controls Cell Proliferation and Cell Death Is Subcellular Localization the Answer? GRB2 FOS PMC7596389__F10 Probable protective mechanism of UDCA against As(III)-mediated cytotoxicity in vivo and vitro BAX NQO1 PMC3782845__F4 Possible origin of WM precursors from IgM+ memory cells CD27 GC CD19 PMC3782845__F5 MYD88—an intriguing link between WM and natural effector IgM+ memory cells TIRAP CD27 TLR4 TLR9 TLR8 IRAK1 TLR5 TLR7 TRAF6 IRAK4 MYD88 PMC1899305__F7 GM-CSF Regulates a PU.1-Dependent Transcriptional Program Determining the Pulmonary Response to LPS TIRAP MAL CD14 IRAK1 TRAF6 MYD88 PMC3110886__F4 Functional analyses of differentially expressed predicted targets of significantly altered microRNAs MADD RPS24 ARHA CP PMC4316180__F3 Tumor necrosis factor (TNF) induced apoptosis pathway and the Fas-Fas ligand-mediated apoptosis pathway FAS TRADD TNF TRAF2 FADD PMC3090136__F1 Prostanoid biosynthesis and response pathway COX1 COX2 PMC4425560__F7 Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway STAT3 MMP2 MMP9 CCND1 PMC8351877__F4 Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy CD40 IFNG CXCR3 STAT3 HEL-S-92n BOC IL27 STAT4 SOCS3 NFIL3 GATA3 RUNX3 PMC3146625__F1 Schematic overview of the steroidogenic pathway HSD3B2 HSD17B4 HSD17B3 CYP17A1 STAR FASN AKR1C1 UGT2B17 UGT2B15 CYP11A1 HSD17B2 AKR1C2 AMACR PMC4962007__F3 Willin, merlin and ezrin are all FERM containing proteins that can influence proper functioning of the cytoskeleton, cell to cell junction complexes (TJ: tight junctions, AJ: adherens junctions) and the hippo signalling pathway LATS1 LATS2 PMC5222873__F4 Nuclear factor Y controls flowering time HEL-S-62p CRY2 CRY1 C9 AGA PMC7389684__F10 Schematic illustration depicting a proposed model of the molecular mechanism of PVT1 in gemcitabine resistance in human pancreatic cancer AGO2 PYGO2 ATG14 CTNNB1 PMC3682205__F3 Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair RHEB TSC2 TSC1 NEDD4 PTEN MTOR PMC6612148__F3 CK2 actions on chaperone machinery (a), NFKB signaling (b), and PI3K/AKT/PTEN pathway (c) PTEN CDC37 NOTCH1 PMC9014248__F3 USP13: Multiple Functions and Target Inhibition ACLY TOPBP1 ATR OGDH BRCA1 ATG14 CDK2 ATM UBL4A BAG6 VCP SGTA PMC6445872__F2 In monocytes/macrophages and adipocytes, SIRT1 deacetylates NFKB(p65), resulting in reduced expression of inflammatory mediators such as TNFA and MCP-1 HEL-S-11 MTOR SIRT1 IRS1 PMC6445872__F5 SIRT6 also attenuates NFKB signaling via histone H3K9 deacetylation at the chromatin level STAT3 SIRT6 PMC10539544__F1 GLUL gene knockdown and restricted glucose level show synergistic inhibitory effect on the luminal subtype breast cancer MCF7 cells’ proliferation and metastasis BAX PIG59 GLS SLC38A1 GLA PMC4019409__F2 Protein Kinase Signaling at the Crossroads of Myocyte Life and Death in Ischemic Heart Disease ROS1 TRADD SIRT2 RAC1 FADD PMC2696318__F3 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE BAD FOXO3A BRAF PTEN MDM2 GRB2 MTOR PMC7685642__F2 miRNAsis involved in up-regulation of the bladder cancer PTEN DEPTOR PMC2696318__F4 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE BAX HBEGF ATR BAD ATM MDM2 GRB2 SRC PMC7685642__F3 Resveratrol, curcumin and paclitaxol affects the mTOR pathway at several stages from inhibition to PI3K to suppression of Akt signaling to prevent the mTORC1 and mTORC2 complexes RHEB TSC2 TSC1 PTEN MTOR DEPTOR PMC7355854__F1 Simplified scheme of the L-arginine/nitric oxide (NO) pathway NOS2 ASL HEL-S-277 ARG1 ARG2 PMC7056575__F1 Signaling via the PI3K pathway and inhibition of PGE2 production by NSAIDs TSC2 BAD TSC1 GSK3B PTEN PMC2696318__F5 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE DUSP5 HBEGF ATR PTEN MDM2 PMC7685642__F1 MTOR signaling cascade TSC2 RICTOR TSC1 RHOB PTEN RHO MTOR EIF4E PMC2696318__F6 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE CDK6 PTEN MDM2 CDK4 PMC2696318__F7 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE BAD PTEN GRB2 MTOR SRC PMC6360145__F3 Her2 signaling pathway in breast cancers NRG2 PDPK1 GRB2 KRAS PMC5725018__F6 Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway LEF1 CTNNB1 PMC6568219__F1 Novel insights into cell cycle regulation of cell fate determination CDK6 SMAD2 ATM CDK4 PMC5693256__F2A DNA repair after oxidative stress: current challenges OGG1 PARP1 PMC11794540__F8 The mechanism by which endothelium-derived AGGF1 attenuates ischaemic retinopathy CDC2 CCNA2 CCND1 TWEAK AGGF1 PMC1895816__F2 Identification of a Bcr-Abl kinase signature VASP DYRK1A BCR CD2AP GSK3B HIPK1 CDK3 PMC6346557__F7 1A,25(OH)2D3 attenuates Il-6 and IL-1Beta-mediated inflammatory responses in MacCM-stimulated human white preadipocytes IL16 RELA IL6 PMC99889__F13 Erk activation following TCR stimulation ZAP70 LAT GRB2 PMC8114918__F6 Schematic figure showing the possible contribution of miR-506 to phenotypic presentation of colitis in patients with PSC + UC compared to those with UC alone SPHK1 PMC4767244__F2 NFKB activation pathways CD40 ATR LTBR RELB ATM PMC4767244__F3 NFKB signaling by oncogenic pathways in GBM ING4 NF1 EGFR ATM PTEN CYLD PMC6889380__F2 Haem synthesis pathway ABCG2 FECH UROD UROS PMC5214729__F4 Proposed renoprotective mechanisms in diabetic nephropathy (DN) through adenosine monophosphate-activated protein kinase (AMPK) activation STRADA TSC2 HMGCR MTOR NRF1 PMC8431402__F10 Comparison of the Effects of Resveratrol and Its Derivatives on the Radiation Response of MCF-7 Breast Cancer Cells BAX FADD PMC10685161__F2 Role of AGR2 as a critical regulator of maintaining intestinal barrier function by affecting the intestinal goblet cell differentiation, maturation, and secretion of MUC2 AGR2 EGF ATOH1 EGFR MUC2 SPDEF GFI1 PMC10685161__F3 Effect of UPR-AGR2 signaling pathways on goblet cells during ETEC infection AGR2 EGFR MUC2 PMC7648344__F1 Activation of MET pathway: pleiotropic effects on cancers through activation of a number of signaling pathways STAT3 BAD HGF MDM2 GRB2 MTOR SRC PMC10685161__F1 Major UPR pathways initiated from the ER and the potential role of AGR2 in interacting with EGFR and MUC2 AGR2 EGFR MUC2 ATF4 EIF2A XBP1 TRAF2 PMC5412772__F1 TRAIL‐ and TNF‐induced signaling complexes—so similar yet so different CASP8 TRADD MLKL PROC FADD PMC9478857__F2 Bronchial smooth muscle cell in asthma: where does it fit? ARHA RAC1 PMC7379270__F3 The mTORC1 pathway RHEB MLST8 TSC2 TSC1 ULK1 ATF4 TRAF6 DEPTOR PMC7379270__F4 The NF‐KB pathway NGF TRADD RELA TRAF5 TNF TRAF2 PMC8619803__F1 Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair RAD52 RFC1 PCNA PML FANCM KDM4B BLM PARP1 FANCD2 SMARCAL1 TOP3A MRE11A DNA2 HLTF ZRANB3 HEL-S-26 SLX4 PMC11829435__F7 Proposed model showing the mechanism of combined HDAC and FLT3 inhibition FLT3 RAD51 NOG WEE1 ATM CD34 PMC4303322__F4 The mammalian DNA damage checkpoint pathways and/or systems HUS1 TOPBP1 ATR ATRIP BRCA1 RAD17 ATM MDC1 PMC7703541__F2 Targeting the renin−angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges AGTR2 MGRA AGTR1 MRGPRD ACE2 PMC8072221__F12 Expressional and Prognostic Value of S100A16 in Pancreatic Cancer Via Integrated Bioinformatics Analyses VMA21 SDHA DLAT NUP214 ACAT2 LZTS1 CS RAB25 ACADM RBM42 PMC3114474__F1 Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer ERBB3 HGF EGFR PMC7094289__F1 TLR signalling - TLR1, TLR2, TLR4, TLR5, TLR6 and TLR10 are expressed on the surface of the cell whereas TLR3, TLR7, TLR8 and TLR9 in intracellular vesicles like endosome and lysosomes TIRAP IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC11012314__F7 Boosting Clear Cell Renal Carcinoma-Specific Drug Discovery Using a Deep Learning Algorithm and Single-Cell Analysis COL21A1 BIRC7 EGF FH TGFB1 CADM2 TGFA CTSK HIF1A DVL2 VEGFA EGLN3 EGLN2 VHL EGLN1 RBX1 CDKN1A TFEB CREBBP EP300 PRCC ELOC PMC9031790__F3 Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin Patents BAX BAD EIF2A PMC6849114__F6 De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry MCIDAS FOXJ1 CCNO NOTCH1 NOTO PMC9316401__F1 Association between Leptin (G2548A) and Leptin Receptor (Q223R) Polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University STAT3 SOCS3 PMC9499815__F8 Trophoblast Exosomal UCA1 Induces Endothelial Injury through the PFN1-RhoA/ROCK Pathway in Preeclampsia: A Human-Specific Adaptive Pathogenic Mechanism USP14 HEL-S-133P HK2 TSG101 ARHA PMC11843251__F11 Metrnl/C‐KIT Axis Attenuates Early Brain Injury Following Subarachnoid Hemorrhage by Inhibiting Neuronal Ferroptosis METRNL GPX4 FACL4 PMC8304079__F1 CAMP in Beta Cell Stimulus–Secretion and Intercellular Coupling VIP GHSR TRPM2 CCK SSTR2 OXR1 TRPM5 GIP NALCN NACA GIPR PMC3970352__F2 Metabolic pathway of Inflammatory Response in humans TH APC PMC8572812__F3 Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases STAT3 IGF1 MTOR JAK1 PMC9086828__F3 Microglia in the Neuroinflammatory Pathogenesis of Alzheimer’s Disease and Related Therapeutic Targets CD36 ADIPOR1 BACE1 CCL5 PMC9549314__F7 We are all aging, and here's why PTEN PPA2 GRB2 PMC4917523__F4 Schematic representation of the interplay between the IGF1 signaling axis and p53 genome protection pathway IGF1 IGF1R MDM2 IGF2 PMC8917441__F7 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis TF MOK APP HEL-S-87p PMC2696318__F1 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE BAX GRB2 SHE PMC8917441__F8 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis CAST CAD TARP APP FADD PMC8811717__F4 Integrated Stress Response, Drug Targets, and Drugs ATF3 GSK3B ELF2 NUPR1 ATF4 TRIB3 XBP1 PMC8572812__F1 Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases STAT3 INSR PTEN MTOR JAK1 PMC8572812__F2 Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases STAT3 IGF1 ARG1 MTOR PMC9124632__F1 Type-I interferons in the immunopathogenesis and treatment of Coronavirus disease 2019 TBK1 CGAS MAVS TLR9 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR3 TLR4 NOD2 TLR8 TLR7 JAK1 TYK2 PMC9031790__F2 Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin Patents ATF4 XBP1 PMC9110208__F9 Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway KEAP1 CTSK NFATC1 MMP9 MTOR TRAF6 PMC7460314__F2 Key pathway of adipose metabolism LPL TG FAS NR1C1 HEL-S-5 FABP4 PMC6555193__F4 Cancer pathway gene set targeted only by natural products for a cancer driver target CCNE2 CCNE1 CDKN1A E2F8 CDKN1B CDK2 E2F7 CCNA2 ARID3A PMC1564204__F6 Schematic pathway of lipid turnover induced by Pi stress PC HEL-S-44 PMC3226388__F3 Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway RHEB RPS6 EEF2K TSC2 EIF4B TSC1 MTOR EIF4E PMC2844927__F3 Routes of interaction between epoxyeicosanoid and endocannabinoid signaling pathways TRPV1 FAAH PMC10536747__F2 Liver and Muscle Transcriptomes Differ in Mid-Lactation Cows Divergent in Feed Efficiency in the Presence or Absence of Supplemental Rumen-Protected Choline SCD HK2 LPIN1 PRKAG2 NR1C2 MAP2K3 PMC8866688__F1 Hypoglycemia Impairs the Heat Shock Protein Response: A Risk for Heat Shock in Cattle? DNAJB1 UBE2G2 HEL-S-102 MAPKAPK5 HEL-S-94n STUB1 PMC10525531__F7 High Hepcidin Levels Promote Abnormal Iron Metabolism and Ferroptosis in Chronic Atrophic Gastritis STAT3 GPX4 PMC10745682__F2 Potential association between the ER stress signaling pathway and obesity ATF4 EIF2A XBP1 IRS1 PMC2801237__F5 Proposed revised model of mammalian DNA damage response ATR RAD50 MRE11A BRCA1 H2AX RNF8 ATM MDC1 PMC3170087__F2 dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity IFNG TLR3 PMC3381108__F2 Unfolded protein response (UPR) BAX CASP3 ATF4 EIF2A XBP1 TRAF2 PMC84049__F9 Control of LHB gene expression by Egr-1, Ptx1, and SF-1 EGR1 GNRHR PMC6423962__F1 Expanded cholesterol synthesis pathway diagram HMGCR EBP SQLE SC5D DHCR24 DHCR7 HSD17B7 TM7SF2 LBR PMC6923311__F4 Homology-directed repair pathway determination and its favorable cell contexts RAD50 MRE11A WEE1 PMC6923311__F1 DSB repair pathways.1017In the C-NHEJ pathway, DSB formation induces binding to broken ends by KU70/80 heterodimers that subsequently recruit the DNA damage response kinase (DDK) complex such as DNA-PKcs in mammals DNA2 FEN1 BRCA1 H2AX GC ATM RIF1 PMC6079365__F2 Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance FAS TLR4 IL1B MYD88 PMC3353643__F6 Proposed model of WNK4 signaling pathway mediating NCC regulation in DCT WNK1 WNK4 SGK1 DCT OSR1 PMC8125460__F2 From Channels to Canonical Wnt Signaling: A Pathological Perspective APC GSK3B AXIN1 MYC CTNNB1 AQP1 PMC9232569__F7 Targeting signaling pathways in prostate cancer: mechanisms and clinical trials ROR1 RNF43 APC GSK3B CTNNB1 PMC5310573__F5 Estrogen metabolism pathway including enzymes (blue field) and chemical compounds HSD17B4 HSD17B3 HSD3B1 HSD17B1 HSD17B2 HSD17B10 HSD17B7 STS PMC4867368__F12 Comparison of the lipoate assembly pathways of E LIPA LIPM PMC8647428__F1 Osteochondroma Pathogenesis SMAD1 FZD8 DKFZp781O1323 PTCH1 LRP5 SHH IHH LRP6 WNT4 WNT2B CTNNB1 PMC3412587__F1 Ras signaling pathway which is disrupted in juvenile myelomonocytic leukemia (JMML) CBL SOS1 NF1 ASXL1 GRB2 PMC8047216__F1 Stem cell migration CXCL11 CXCR3 EPO CCR4 CCR3 BDNF CXCR4 PMC6072433__F6 Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids DNAJC1 CYP2E1 CTNNB1 PMC6072433__F4 APAP-sensitive proteins related to protein synthesis TMED7 RPL12 HEL-S-100n CAND1 CTNNB1 RPS11 MAPK3 PIG59 RPS3 EEF2 SKP1 EIF3B RPL4 CACYBP CLDN1 PMC4981742__F1 Mitochondrial dysfunction in gliomas- Evasion of Apoptosis: Impaired mitochondrial function due to the genomic mutations in mtDNA leads to impaired function of electron transport chain thus enhancing generation of ROS BAX EGF MDM2 MTOR APAF1 PMC11076710__F9 Nrf2/ARE signaling pathway, mitochondrial ROS, and NLRP3 inflammasome in renal tubular epithelial cells under high lipid conditions NLRP3 KEAP1 NQO1 PMC8272378__F2 Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis GLDC TOMT PXMP2 IDH3B NDUFV3 DBT HIF1A LDHB PDK2 ACSS2 RPL15 GCSH SUCLA2 LIAS OGDH AMT DLD AASS PMC7466429__F2 Signaling pathways activated by catecholamines STAT3 USP28 HEL-S-133P MDM2 MYC PMC7466429__F3 Stress hormones on the immune system COX2 APC TNF PMC7596389__F9 Schematic presentation probable protective mechanism of Ursodeoxycholic acid (UDCA) against As(III)-mediated hepatic injury by activating the Nrf2 pathway GPX8 HMOX1 BAX CASP9 KEAP1 NQO1 CYCS CASP3 NFE2L2 BCL2 HEL-S-44 PMC6116077__F3 Interferon pathway IFNG STAT1 STAT2 IRF9 JAK1 TYK2 PMC2696566__F1 Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy CDC42 HRAS PTEN IGF1R RHO MTOR SRC MEF2C IRS1 PMC2696566__F2 Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy ATR ATM PARP1 PMC10968558__F6 Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review HEL-S-22 ATXN3 HEL-S-72p BAX PLCB4 CYCS HMOX1 BCL2L1 GSTA4 NQO1 GCLC HSF1 NFE2L2 PPARGC1A SYT1 HEL-S-44 PMC8389183__F5 Recent ecophysiological, biochemical and evolutional insights into plant carnivory TF KIN PMC5297839__F1 Phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR), retrovirus-associated DNA sequences/mitogen activated protein kinase (RAS/MAPK) pathways and c-MYC are master regulators of cell growth and proliferation RPS6 POLI PTEN EIF4E PMC10968558__F2 Mitochondrial dysfunction in the pathogenesis of SCA3 ATXN3 BAX CYCS BCL2 PMC8552808__F3 Treatment of COVID-19 with Traditional Chinese Medicine: What Herbs Can Help Win the Battle with SARS-CoV-2? APC TNF PMC10968558__F3 Alteration of DNA damage response in the pathogenesis of SCA3 PNKP BAX ATR CHEK1 ATM PMAIP1 MDC1 PMC9288037__F1 Biomarker discovery for practice of precision medicine in hypopharyngeal cancer: a theranostic study on response prediction of the key therapeutic agents STXBP4 FUS HEL113 PCNA EGFR MYBL2 TUBB4B KLK11 NINJ2 TUBA2 PTEN TERT TUBB6 MYC MMP2 PC PDE4D SELENOW TUBB4A FABP4 PARP1 AGR2 RAB15 NONO RELA TP63 ERBB2 CDK2 BCL2 GJA1 LMNA YWHAZ PMC6854373__F8 Graphical abstract of how EGFR signaling pathway and downstream effector inhibit the miR-124a expression and the role of ETS2 in insulin production in pancreatic beta cells PDX1 ETS2 FOXA2 PMC2923715__F5 Wnt signaling pathways ARHA NPHP3 CTNNB1 PMC8027424__F1 Autotrophic and mixotrophic metabolism of an anammox bacterium revealed by in vivo 13C and 2H metabolic network mapping POR HEL107 RPE FH CS PMC7923692__F1 RPTOR BioID2 reveals spatial association between mTORC1 and FAs TCIRG1 PIK3CA CAB39 PXN CARD11 PIK3CD GSK3B TTI1 TLR9 ASAP1 MYC VAMP8 PRKAA1 HAX1 GRB10 MAPKAP1 ETV6 PIK3R4 EIF3F AP2A2 AKT1S1 CSNK1A1 SRC HEL-S-44 AP2S1 LIMS1 DNAJB1 DEPTOR IRS1 EIF4E RHEB MLST8 RAB3GAP1 VPS35 TSC2 RICTOR TSC1 CUL7 ARHGEF7 GRB2 SEH1L SNAP23 GNAI3 SLC3A2 VPS13D CALD1 ARPC2 PHACTR4 ARL8A SQSTM1 PPP2CA CEP192 TNS1 MTOR LAMTOR2 AKR1B1 IGF2R HEL-S-128m LIMD1 NAPG PEAK1 TLN1 LAMTOR1 LPP RRAGA EIF4EBP2 RPTOR RPS6 EIF4B TBKBP1 RRAGD CGN EIF4EBP1 PARVA ANXA6 RSU1 LAMTOR3 ANXA1 ARHA EML4 MAJN TNS3 RPS6KB1 IKBKB KANK2 INPPL1 LYN PMC3012004__F2 Sites of action for inhibitors and shRNAs in the EGFR-PI3K-Akt-mTOR pathway TSC2 RICTOR TSC1 EGFR PTEN MTOR IRS1 PMC8005514__F3 PI3K/AKT pathway and HER2-targeted therapy resistance PTEN IGF1R MUC4 MTOR PMC8005514__F4 PI3K/AKT pathway is related to chemotherapy, CDK4/6 and PARP inhibitor resistance CDK6 KEAP1 GSK3B PTEN MTOR SRC SSB CDK4 PMC8005514__F1 PI3K/AKT signaling pathway in breast cancer BAD PTEN PMC3012004__F1 PI3 kinase signaling pathway in glioma TSC2 BAD RICTOR TSC1 EGFR GSK3B PTEN IGF1R MTOR CCND1 PMC2928642__F8 The PA-mediated activation of mTORC1 signaling RHEB LPA TSC2 TSC1 PC PMC10239497__F10 Dissecting specific Wnt components governing osteogenic differentiation potential by human periodontal ligament stem cells through interleukin-6 FRAT1 APC LRP5 LRP6 CTNNB1 PMC6643108__F5 Relation graph of KEGG pathways in which differentially expressed genes were significantly enriched CCNE2 FAS PCNA LAMC2 MAPK9 FOS PMC4241130__F2 Energy Metabolic Re-Programming in the Hypertrophied and Early Stage Failing Heart: A Multi-systems Approach ACAN HEL-S-5 ACADM PMC8503815__F2 Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer BAX CASP9 BAD CASP3 PTEN ATF4 PMC3877975__F5 Coordinately up-regulated genes of chemokine signaling pathway in monocytes from the VIR group (VIR versus BDL) ARHA GRB2 SHE DOCK2 PMC5342747__F5 Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells EGF IGF1 EGFR IGF1R PMC8136775__F1 Untangling the crosstalk between BRCA1 and R-loops during DNA repair RAD52 RAD51 DNA2 BRCA2 PALB2 BLM PARP1 PMC3976145__F1 Genes involved in the WNT signaling pathway APC LRP5 LRP6 TEF PMC8156432__F8 Orai1 Channel Regulates Human-Activated Pancreatic Stellate Cell Proliferation and TGFB1 Secretion through the AKT Signaling Pathway TGFB1 ORAI1 STIM1 PMC3826118__F1 Role of Calcium, Vitamin D, and the Extrarenal Vitamin D Hydroxylases in carinogenesis CASR NR1i1 CYP24A1 COX2 TCF4 CTNNB1 PMC7916216__F2 Direct and indirect effects of radiotherapy, chemotherapy, and protein kinase inhibitors on NK cell activity HLA-G GSK3B BRAF CXCL16 MICA ULBP2 PMC7882494__F7 Pathway analysis DKK4 ACVR2A SMAD2 APC BRAF PIK3R1 SMAD4 PTEN IGF1R MYC KRAS IGF2 AXIN2 TGFBR1 CTNNB1 TGFBR2 ERBB3 DKK3 CHEK2 NRAS ERBB2 ATM RPS6KA3 PMC8282181__F3 Protein Kinases: Potential Drug Targets Against Schistosoma japonicum CBL FOXO1 GRB2 MTOR PMC8282181__F4 Protein Kinases: Potential Drug Targets Against Schistosoma japonicum CDC42 GRB2 TNF TRAF2 PMC7669714__F3 DNA replication restart pathway choice REV1 POLK POLDIP2 PRIM1 PRIMPOL POLN PMC10503159__F9 Proposed model depicting the possible mechanism of bta-miR-223 on mediating inflammatory injuries and oxidative stress via regulation of NLRP3 inflammasome and Keap1/Nrf2 pathway NLRP3 KEAP1 TLR4 PMC8122117__F4 Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic targets MBOAT7 MTOR GPR55 PMC4272512__F2 Immune, antioxidant and inflammatory targets that L-glutamine, L-arginine and BCAA are involved NOS2 GLS HSF1 MTOR SIRT1 HEL-75 PMC3705552__F2 TIR8/SIGIRR, a negative regulatory receptor of ILR and TLR signaling SIGIRR MTOR MYD88 PMC6441003__F7 Proposed model for the impact of Metformin on FOXO3a and gene transcription in primary human fibroblasts RHEB IL-21 TSC2 TSC1 IL1A IL6 PMC12081257__F1 Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression KEAP1 GCLM NQO1 GCLC PMC1186734__F6 Glucocorticoid Receptor-Dependent Gene Regulatory Networks PPARG IGFBP1 YY1 MYC PCK1 ABCA1 MMP11 STUB1 TXN STAT1 CKS1B E2F4 HLA-G PPARGC1A GAS1 HEL2 SMARCA4 MAPK1 MMP7 JUN ETS2 NR1H3 ADM PSMB8 SERPINA1 B2M TNF NCOA1 NR3C1 FNTA HOXA5 APOA2 EIF4G1 ONECUT1 NR1C1 NR2A1 DBI RELA CASP3 HSPA4 HLA-B HLA-C NFKBIB BRD2 PMC8383365__F1 Pyroptosis at the forefront of anticancer immunity NLRP1 GSDMD NLRP3 GSDMC GSDMB AIM2 RIPK1 DFNA5 RHO GSDMA IL1B FADD PMC6833007__F1 Mechanisms involved in activation and regulation of NLRP3 canonical pathway IL16 SIRT2 EIF2AK2 MYD88 PMC7166547__F2 Innate immune response and adaptive immune responses of Coronaviruses (CoV) infection during an infection TIRAP TLR3 TLR4 IRF3 IRF7 IRAK4 MYD88 PMC7180609__F7 Glutamine-dependent metabolic pathways in T HAL PRODH PMC6383680__F6 Nucleotide-binding oligomerization domain-containing protein (NOD)1 and NOD2 signaling cascades MAP3K7IP1 ATG16L1 ATG12 TAB3 TRAF5 NOD2 NOD1 TRAF6 ATG5 TRAF2 UNK PMC6734087__F2 Canonical transforming growth factor (TGF)B and noncanonical pathways in endothelial to mesenchymal transition (EndMT) ACTA2 SNAI2 SNAI1 SMAD2 SMAD6 SMAD4 MTOR TWIST1 PMC6734087__F3 Diagrammatic representation of other pathways involved in endothelial to mesenchymal transition (EndMT) regulation ACTA2 SNAI1 SMAD2 SMAD4 HIF1A NOX4 PMC11520539__F3 Diagram illustrates the immune exchange pathway mediated by ADAR1, a dsRNA A-to-I editing transformation modulating enzyme ADAR LIN28B IL3RA PMC5968182__F1 Hypothetical roles of linear and circular ANRIL lncRNA in regulating inflammation and cell survival in human vascular endothelial cells and potential drug targets PES1 YY1 IL6 PMC6023503__F2 IPA pathway analysis, in which specific genes emerged throughout our review, are shown in purple TRIM52 ZNF706 HTT PMC7268359__F6 Schematic diagram of the mechanism of soyasaponins’ regulation on TLR4 signaling pathway TIRAP CD14 IRAK1 TRAF6 LBP IL1B MYD88 PMC6005741__F1 The force is strong with this one: Metabolism (over)powers stem cell fate VIT ACLY EGFR APC MTOR CTNNB1 PMC5834423__F1 MicroRNAs (miRNAs) targeting insulin signaling mediators FOXO1 GRB2 KRAS IRS1 PMC5019081__F3 Wnt signaling pathways regulate gene expression and cell movements CDC42 APC ROR2 LRP5 LRP6 ARHA RAC1 PMC3717758__F3 Structure–activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease APOE APP GGA1 PMC7880430__F2 Finding branched pathways in metabolic network via atom group tracking CR2 DKFZp666G145 ACD CR1 PMC5344939__F1 Molecular mechanisms of PI3K-AKT-mTOR signaling cascade related neurodevelopmental diseases PTEN FOXG1 PMC2679770__F3 Proposed saxitoxin biosynthetic pathway C2 STS PMC9466315__F4 Immune responses to Lassa virus TBK1 TLR1 MAVS TIRAP APC TRAF3 MYD88 PMC3390254__F1 An emerging role of mTOR in lipid biosynthesis RHEB MLST8 TSC2 TSC1 SGK1 MTOR DEPTOR PMC4151049__F2 Biochemical Signaling of PD-1 on T Cells and Its Functional Implications FYN LAT PTEN CPT1A PMC4859290__F7 Analysis of signaling pathways specific to base:apex comparison COX7B RPS6 RPS21 RPS23 NDUFS5 ELF2 MTOR UQCRQ PABPC1 NDUFA11 SDHD RPS16 RPS27 RPS26 ELF4 SDHB RPS3 RPS17 ZNF183 RPS25 ELF3 PMC8278124__F8 Astragalus polysaccharide attenuates LPS‐related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway TLR4 CTSK NFATC1 IL6 TRAF6 TRAF2 PMC9155915__F7 Pharmacological Mechanism of Shen Huang Chong Ji for Treating Alzheimer's Disease Based on Network Pharmacology and Experimental Validation RHEB TSC2 GAL BAD BCR CYC1 CD19 GRB2 MTOR RAC1 EIF4E PMC6822174__F1 Cell metabolism ACLY FH GLS FASN HEL-S-5 PMC5343902__F2 Mammalian target of rapamycin (mTOR) pathway RHEB EGF TSC2 TSC1 ULK1 EGFR PTEN GRB2 PMC5451429__F8 Proposed model for the effects of GSK3B inhibitors on HCV virion particles’ assembly/release APOE GSK3B APOB PMC8914022__F1 Weighing in on Adipogenesis IVD GLS SIRT4 MCCC1 PMC3823580__F8 Synergistic Effect of Everolimus and Chloroquine on Endothelial Cell Number Reduction Is Paralleled by Increased Apoptosis and Reduced Autophagy Occurrence BAX CLC BCL2 MTOR EIF4E PMC3992201__F2 Genes identified in GWAS of Phase 1+2 AA subjects using a case-control model in the canonical pathway “calcium signaling.” The gene or gene families with a significant association result are shown in orange HEL-S-99n CAD PMC2702844__F2 Cell biology of autophagy in metazoans: a developing story RHEB TSC2 TSC1 BCL2 PMC8656925__F1 Targeted Therapy in HR+ HER2− Metastatic Breast Cancer: Current Clinical Trials and Their Implications for CDK4/6 Inhibitor Therapy and beyond Treatment Options CDK6 MTOR CDK4 PMC9688771__F2 Sweet Warning: Mucin-Type O-Glycans in Cancer GBF1 GAL SRC PMC9192598__F2 Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter JUN EGR1 MYH10 CXCL1 THBS2 COCH STK4 IFI16 MMP9 IL6 GBP1 ABCA1 pk ANGPTL4 SOX9 TFPI ITGA2 AKAP12 S100A9 BIRC3 PMC9192598__F3 Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter TNC KRT10 JUN CSF2 TGFA LIF PLAUR MMP9 CYP1A1 FOS HMOX1 EREG IL24 IL1RN IL18 SERPINB2 LCN2 TNFSF10 DCN PMC7052851__F1 Cholesterol biosynthesis pathway in cancer cells ACAT1 HMGCR ACAT2 SQLE PMC3278830__F3 Functions related to hepatic cultures.Subgraphs of a hepatocyte response network induced by genes annotated with MSigDB gene sets NR1H3 CYP2E1 PSMB8 LOC51064 MGST1 ANAPC2 RXRG ADH7 UGT2A1 NR2A1 ITGA1 GSTM3 ACTN4 WEE1 CHEK1 ITGA6 NRAS MCM6 PFN2 NR5A2 RRAS2 PMC7235470__F1 Cytokine storm and stress can increase gut dysbiosis/permeability, further contributing to cytokine induced IDO and TDO, leading to kynurenine and kynurenic acid, which activate the AhR to increase CYP1B1 and regulate the NAS/Melatonin ratio CYP2C19 PDC AANAT AHR ASMT CYP1B1 PMC9181382__F4 Rethinking Sesquiterpenoids: A Widespread Hormone in Animals HMGCR PMVK MVK PMC9373414__F1 CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial APC NOTUM DKK2 WIF1 PMC1088000__F4 In Silico Analysis of the L C7 F5 HEL-S-5 PMC3131135__F1 Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection TLR9 IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 TLR7 PMC3131135__F2 Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection MAVS IRF3 PMC7919196__F2 Pathogenesis of COVID-19, showing the involvement of components of the fibrinolytic system in various steps TMPRSS2 PLG ACE2 PMC3540170__F4 Immunoregulatory role of anchored cAMP signaling in T cells TLR4 CD14 FOXP3 LCK PMC3975429__F1 MAPK signalling cascades leading to MK5 activation PAK1 PMC5224989__F3 Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring RHEB TSC2 BAD FAS INSR GRB2 MTOR INS EIF4E PMC5655190__F14 Sodium fluoride induces renal inflammatory responses by activating NFKB signaling pathway and reducing anti-inflammatory cytokine expression in mice IL10 IL4 IL1B PMC9635866__F6 Realgar-induced KRAS mutation lung cancer cell death via KRAS/Raf/MAPK mediates ferroptosis GPX4 FACL4 KRAS PMC7862443__F2 Met1-Ub Machinery FAT10 SHARPIN OTULIN CYLD PMC7724447__F1 Role of statins and PCSK9 inhibitors in COVID-19 pathophysiology and complications PCSK9 LDLR ACE2 MYD88 PMC5562164__F3 Innate Immunity to Intracellular pathogens: balancing microbial elimination and inflammation GAL ATG16L1 HEL-S-62p IL16 ULK1 ISG15 PMC3877903__F9 Fumigaclavine C-induced apoptosis in MCF-7 breast cancer cells through the mitochondrial pathway BAX BAD CDK2 BCL2 CCNB1 PMC3996160__F6 A hypothetical model depicting the mechanisms used by SARS-CoV PLpro-TM to disrupt the STING-TRAF3-TBK1 complex required for activation of the IFNB production pathway TBK1 MAVS IRF3 TRAF3 PMC5841288__F9 Model of the Itch/Beta-arrestin2-dependent regulation of the SuFu/Gli3 complex function ITCH SUFU PTCH1 SHH SMO MB GLI3 PMC6217971__F3 Co-occurrence networks of diagnostic KOs involved in major energy and carbon fixation metabolic pathways in Llamara microbial mats from pond LLA9 DERA SOX2 SDHD SDHA SDHB NIFK COX2 PDC COX3 DLD HP AADAT SDHC COX11 PMC5853495__F7 Model for biosynthesis of sterols and other isoprenoids in rice roots LPA IPP DAP PMC6104109__F2 Canonical pathways of oxidative phosphorylation and mitochondrial dysfunction NDUFB2 COX7A2 NDUFS8 PMC1798432__F8 Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages IFNG TLR4 ATF2 PMC11006482__F9 Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice HADHB NLRP3 TNF SIRT1 PMC5311241__F9 A positive feedback loop from Snail to Cat L to CUX1 and back to Snail drives EMT and can be inhibited by Cat L inhibitor Nbla10317 PMC4484807__F6 Immunological Response to Single Pathogen Challenge with Agents of the Bovine Respiratory Disease Complex: An RNA-Sequence Analysis of the Bronchial Lymph Node Transcriptome CD40 TIRAP CTSK TLR9 CD14 CPO IRF3 TRAF6 IRAK4 RAC1 MYD88 TLR4 PDC LBP CD6 FADD PMC4654299__F2 Regulation of endosomal trafficking RAB27A RAB7B RAB27B ARF1 ARF6 RAB22A PMC7911386__F2 Signaling pathways of obese/T2D cell, of critical COVID-19 cases CRP BAX EGR1 NLRP3 TLR8 IRAK2 IRF7 TLR7 CCL2 ACE2 IL1B MYD88 PMC4055129__F1 Inhibition mechanism of MTX in DNA synthesis pathway DHFR MTRR FPGS PMC8584169__F2 Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease TREM2 CX3CR1 CX3CL1 BDNF PMC6967775__F1 Synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas EGF EGFR MTOR PMC7843454__F3 Peroxisomal and mitochondrial fatty acid oxidation are dysregulated in both early and late CKD GAA ETFA ETFB ACADS PMC6682659__F3 Molecular consequences of the PrPC/AB interaction in AD FYN ABO PMC7599912__F3 Metabolic Pi sensing in mammals (modified from ) CASR FRS2 GRB2 SPX IP6K1 PMC12116377__F2 Summary diagram illustrating PD-L1-related immune sensitivity and resistance mechanisms in GC HPD CD44 GC FOXP3 PMC7028128__F8 Proposed model linking the miR‐574‐5p locus to the biology of goat mammary epithelial cells (GMECs) CDC42 RPS6 BAX EGF EIF4B JUN BAD EGFR AKT3 MTOR MAP2 MAP2K4 MAP2K1 CCND1 PMC8718268__F4 Dynamics of Wnt signalling RNF43 APC LRP5 ZNRF3 LRP6 GPR49 CTNNB1 LGR6 PMC8453690__F2 Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke BAX BAD MMP9 BDNF TNF PMC6713433__F6 mRNA-miRNA-pathway regulatory network TNFSF8 GRK1 IL8RB IL12B PMC8835409__F5 Estrogen Receptors-Mediated Apoptosis in Hormone-Dependent Cancers BAX TAF9B FOXL2 PTEN PMC2964873__F1 The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities SIAH2 SOX9 HES6 HIF1A FOXA2 PLOD2 PMC3848785__F3 Schematic diagram of the known PtdEtn biosynthetic pathways PSD2 PMC6769509__F3 Flavonoids as anti-diabetic agents: Modes of Action VEGFA PMC8388033__F4 Multi-layered network-based pathway activity inference using directed random walks: application to predicting clinical outcomes in urologic cancer FAS TGFB1 ACADSB CDC23 FACL4 GNG12 AIRE FADS1 MAPK3 PYGL OXSM PIG59 CREB3L4 HAL ABCD3 ALOX15 ABCC3 ACOX3 PRPF19 PYGM GNG13 ITGB7 STAT2 PYGB ACADS NTRK2 CDC34 HLA-DQB1 GNG2 IDUA HLA-DMA ABCG8 CHMP4C CALM1 ABCC9 ABCA4 PMC8874859__F4 How RSV Proteins Join Forces to Overcome the Host Innate Immune Response TF SOCS1 TBK1 MAVS STAT2 IRF9 IFIT1 IRF3 IRF7 SOCS3 TRAF3 STAT1 TRIM25 IFITM3 OASL JAK1 TYK2 PMC6479799__F2 Mechanism of CB-R-mediated antitumor activity in breast cancer cells JUND ARHA MTOR SRC GPR55 CTNNB1 PMC7294576__F9 Beta-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NFKB Signaling Pathways CDH2 CD44 BAX PMC2966480__F4 E3 ubiquitin ligase activities of KEAP1 and AHR RBX1 KEAP1 AHR PMC5504455__F10 Diagrammatic summary of the principal ways by which the Unfolded Protein Response pathway may interact with the mTOR/AKT pathway to modulate protein synthesis within the placenta EEF2 MTOR EIF2A EIF4E PMC3488210__F3 Sub-network found among the genes in a differential expression experiment that compares FA patients to controls MYB BAD NPEPPS APC ERG MTOR PMC3488210__F5 Significant sub-networks (see also ) found among the lists of most essential genes, ranked by the RIGER parameter, obtained for both cell lines: (A) Jurkat and (B) K562 RELB XAB2 MYC RPS7 HEL-S-47e YEATS4 MBIP MCCC2 LYAR RELA ATM RPL7 VPS72 CNBP PMC5776165__F1 MAPK signaling pathway, where each MAPK phosphorylates several transcriptional factors, regulating protein expression AK1 ATF2 MYC MEF2C MEF2D PMC3170087__F4 dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity IRF3 TRAF3 FADD PMC4060077__F1 Molecular switching from apoptosis to necroptosis BAX PGAM5 MLKL TNF FADD PMC5937214__F7 Signaling pathways between palmitate and TNFA for CCL2 production CPZ TLR4 IRAK1 IRF3 TRAF6 CCL2 TRAF2 MYD88 PMC5393155__F10 Insulin receptor signaling pathways ELF4 PTEN MTOR IRS1 PMC8577797__F6 Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway RHBDF2 STAT3 EGF ADAM17 EGFR PACS2 EIF2A PMC3769702__F5 Pathway diagram of the CTLA4 signaling in cytotoxic T lymphocytes from the IPA SYK CD80 PLCG1 FYN LAT CTLA4 GRB2 LCK PMC3172806__F7 A model of pericyte-induced EC survival signaling VTN VEGFA PMC6121264__F6 Putative targets of down-regulated miRNAs in SHH MB CSC enriched pathways, include (A) pathways in cancer and (B) PI3K-Akt pathway RHEB EGFR GRB2 MYC CTNNA1 RAC1 CTNNB1 PMC9502483__F2 Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease NLRP3 SCARB1 CD36 TLR4 MMP9 PMC4687464__F2 Wilms' tumor 1 (WT1) contributes to metanephric mesenchyme self-renewal and its differentiation SALL1 WT1 LHX1 HOXD11 PAX2 BMP4 SIX2 BMP7 WNT9B WNT4 BMPER GAS1 PMC7465315__F1 Keratinization at a glance TGM1 TGM3 PMC5354742__F3 Gene expression profiling of tumor-initiating stem cells from mouse Krebs-2 carcinoma using a novel marker of poorly differentiated cells NTS SLC2A4 NFATC2 ABCA1 ADRB3 FGFR1 GPA2 ALOX15 MMP2 RIIAD1 PDE4D ITM2A GATA6 PDE7B PER2 tal-1 TDO2 PDK4 NPPA IGF1 PON1 NT5E PROK2 CD200 CP PF4 PMC6815045__F3 PI3K-Akt signaling pathway SYK CASP9 EIF4B BAD RBL2 PTEN CD19 MTOR ME1 MYC RAC1 EIF4E RHEB TSC2 CA3 SIPA1 BCR RXRA MEI1 MDM2 GAB2 PMC7700122__F2 Under normal homeostatic conditions, Keap1 homodimerizes through the N-terminal BTB domain and binds to the cullin-based (Cul3) E3 ligase, forming Keap1-Cul3-RBX1 (Ring box protein-1) E3 ligase complex, leading to Nrf2 ubiquitination and degradation RBX1 KEAP1 GCLM NQO1 PMC9672378__F1 Myeloid and lymphoid cell development by O-glycans on Notch EGF MAML1 DLL4 ADAM10 NOTCH1 PMC10035973__F6 RNA-seq and microRNA association analysis to explore the pathogenic mechanism of DHAV-1 infection with DEHs MFN2 TRAF3 BCL2L13 PMC8624316__F1 Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition DNMT3B TDG PMC7423897__F3 Overlap of identified miRNA targets with pathways related to the pathogenesis of atherosclerosis TF CD40 TNFRSF12A TNFRSF14 CCR2 CCR3 CXCR4 PMC9679015__F2 Polymerase D-interacting protein family and their emerging roles in diseases CDH2 LIPT1 ECT2 TRPV1 POLDIP2 HIF1A ARHA CLPX CCND1 NOX4 PMC5090832__F1 JAK/STAT, Raf/MEK/ERK, and PI3K/PTEN/Akt/mTOR pathway cascades.In the JAK/STAT pathway, JAK2, which can be inhibited by AG490 and/or SOCS3, can phosphorylate STAT3 through downstream signalling STAT3 PTEN SOCS3 MTOR PMC5090832__F2 Proposed signaling mechanism underlying the neuroprotective role of tPA.tPA enters the cell where it indirectly activates cellular signaling mechanisms, including Janus kinase 2 (JAK2) and/or mammalian target of rapamycin (mTOR) STAT3 MTOR PMC7922220__F2 GnRH-II signaling in ovarian cancer cells assuming that a truncated GnRH-II receptor (A) or no GnRH-II receptor (B) exists BAX EGF JUND EGFR PMC7599984__F1 Wnt signaling pathway GSK3B LRP5 LRP6 PMC11206395__F3 Therapeutic mechanism of polyphenols for anxiety disorder IL11 BDNF PMC7922220__F1 GnRH-I receptor signaling in ovarian cancer cells EGF JUND EGFR GRB2 SRC PMC7599984__F3 TGFB family signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC7599984__F4 Hedgehog signaling pathway BOC SUFU SMO PMC6503366__F5 “Cytokine–cytokine receptor interaction”, “steroid biosynthesis” and “cell cycle” pathway and the identified regulator PRLR CDC2 EGF SMAD1 DKFZp781O1323 PCNA EGFR DHCR24 EPO VEGFA CCNA2 BMP6 STAT1 EPOR CDK2 TPO AMH CCNB1 CCND1 PMC3362297__F11 Proposed roles of the calcineurin signaling cascade in stress responses, drug tolerance, and virulence in C MID1 HEL-S-84 RCN2 PMC10242157__F7 Versatile role of Serpina3c in physiological and pathological processes: a review of recent studies FOXO1 TLR4 ENO1 CTNNB1 PMC7823885__F3 Pathways of lipid metabolism modulation in hepatic tissue by the Gl-2 extract of a Mexican strain of Ganoderma lucidum, under a high-cholesterol diet (HCD) given to C57BL/6 mice ACLY HEL-S-103 JUN SIK1 EGR1 DNAJB1 FASN FOXA3 ACACA ME1 ELOVL5 HEL-S-70p FOS ACSS2 ATF3 MOXD1 BTG2 FDPS EGR2 PMC6147049__F3 ER signaling pathway HIF1A IL6 CCND1 PMC6147049__F4 HER2 signaling pathway MDM2 GRB2 MTOR PMC6147049__F5 Canonical Wnt/Beta-catenin signaling pathway CD44 MMP7 APC GSK3B CCND1 PMC2933905__F2 Distinct functions for TPPII in the nucleus and cytosol BAX ATM SSB PMC11978336__F5 Interaction between lipid metabolism and macrophage polarization in atherosclerosis ABCG1 IL10 NLRP3 TLR4 ABCA1 PMC12170582__F5 This figure illustrates the diverse neuroprotective effects of Rut and its underlying molecular mechanisms CA3 NGF GDNF TLR4 BACE1 APP BDNF PMC9349561__F5 Exploration of molecular targets and mechanisms of Chinese medicinal formula Acacia Catechu ‐Scutellariae Radix in the treatment of COVID‐19 by a systems pharmacology strategy BAD MMP14 STAR SORD SELE ITCH ELL AIP RBL2 CD19 TSC2 PAF1 BRCA1 C2 NOD2 EMB TRAF2 PMC12170582__F3 This figure reveals important factors in anti-inflammatory signaling pathway of Rut in the CNS microenvironment NLRP3 COX2 TLR4 ARG1 PMC1201250__F7 Mechanism of TgHSP70 tolerance in PMs from WT mice TG TLR4 IRAK1 IRF3 TRAF6 MYD88 PMC7847688__F3 Roles of Pin1 in virus infection STAT3 PIN1 CCND1 CTNNB1 PMC6781638__F4 Pathway analysis shows the identified proteins and their respective interactions SLC25A5 NDUFB2 ADORA2A PINK1 NDUFB11 CYCS NDUFS5 PRRG2 CYC1 TCF4 SNAP91 HEL-S-51e SNCAIP DAO DRD1 DRD2 DRD4 NDUFB4 NDUFB1 NDUFA3 HCN1 UQCRH CNTN4 NDUFC1 APAF1 UBB APOC3 MCAM CASP9 TMTC1 APOE APC SNCA FCGBP TNF SDHD SDHA PRKACG FES SDHC VDAC3 HTRA2 GNAI3 GIGYF2 PPIF NDUFB9 NDUFA6 SHANK3 RTN4R CACNA1I UQCRB SLC18A2 OTUD7B APP COXFA4L2 SLC1A1 GNAI1 HEL-S-67p LRRK2 DPYD ETF1 PTGIS SLC25A6 RGS4 NFATC3 ZDHHC8 COX7B NDUFB6 PRKD1 ADAMTSL3 STAG1 SMG6 NDUFV2 NDUFA7 NDUFA13 NDUFAB1 NDUFA10 PPP3CC NDUFS3 COXFA4 SLC25A4 CFI NDUFS6 A2M SRPK2 DTNBP1 UBA7 HEL-117 UQCRC1 RGS6 UQCRFS1 NAB2 AMBRA1 ZNF183 LAMA4 BDNF NDUFS1 COX6B1 SYN2 NDUFB8 NDUFA12 UBE2J2 UBE2G2 UBE2J1 GPR37 UBE2L6 NDUFV3 NDUFA9 HEL-S-62p UQCR10 COX7C NDUFS8 HTR2A UQCRQ NDUFA11 NDUFS4 UQCRC2 NDUFB7 PAK6 NDUFB3 EPC2 UBE2L3 COX6B2 MAD1L1 ZNF536 NRGN GRM3 SLC18A1 COX8C TPSG1 NDUFC2 UQCR11 UBE2G1 CLCN3 APOL4 UBQLN1 APOL2 ZNF804A GNAL RERE NDUFB10 NRG1 CASP3 VIPR2 NDUFA2 DISC1 PMC5974360__F10 Wnt/Beta-catenin and hedgehog signaling in myofibroblast differentiation FZD10 WNT7B WNT10A CTNNB1 PMC2885761__F2 Schematical overview of the signaling pathway mediated by MC1R RAB27A MC1R PMC6678287__F6 Simplified pathways showing the effect of F-6 cell proliferation and death BAX CASP9 CASP3 MTOR PMC4699037__F1 Signaling affecting stem cells identity and their interplay with chromatin TES KLF4 STAT3 FGF7A SMAD2 BMP4 LIF SOX2 GSK3B NODAL FGF2 PMC11978336__F2 Interaction between lipid metabolism and macrophage polarization in atherosclerosis CRP ABCG8 ABCG5 CYP7A1 PMC11978336__F3 Interaction between lipid metabolism and macrophage polarization in atherosclerosis VCAM1 TNF SRA1 PMC6121264__F5 Putative targets of up-regulated miRNAs in SHH MB CSC enriched pathways, include (A) pathways in cancer, (B) PI3K-Akt pathway, and (C) protein processing in endoplasmic reticulum SEC61A1 UBE4B HEL-S-107 CANX RAF1 DDIT4 PIK3R2 HEL-S-269 GNG12 GANAB VCP MBTPS1 MAPK3 TRAF4 FGFR1 CHUK AMFR NPLOC4 CCND1 MAPK1 UBQLN1 PPP2R1A ITGB1 HEL-S-125m SAR1B SKP1 DNAJB11 SSR3 SSR2 PMC11978336__F1 Interaction between lipid metabolism and macrophage polarization in atherosclerosis LPA BAX PC PMC3575576__F6 Proposed signaling pathway TWIST1 PMC4377308__F3 Genetic alterations of protein tyrosine phosphatases in human cancers STAT3 CAD PTPN11 PTPRT SRC PMC2908016__F2 Therapeutic HPV vaccines PMC6627937__F7 Graphical illustration of the proposed mode of FBXW5-induced regulation of intracellular signaling in gastric cancer CDC42 ROCK1 FBXW5 ARHA SRC PMC2708714__F2 Direct targets of WT1 identified in the Wnt signaling pathway DACT1 APC TBL1X NLK CTNNB1 PMC6347501__F3 ‘Stemness’ maintenance pathways in CSCs HEL-S-133P APC GSK3B LRP5 LRP6 SMO HIF1A PDK3 PDK2 ABCG2 TEF CTNNB1 PMC8394908__F3 Splicing factor mutations in hematologic malignancies ERF UPF2 MEPCE UPF3B CDK9 MAGOH PMC8949786__F5 Characterization of Accessible Chromatin Regions in Cattle Rumen Epithelial Tissue during Weaning MAPK1 SMAD1 SMAD2 SMAD6 KRAS FOS TGFBR2 INHBB INHBA NR2A1 RALA TMEPAI INHA ZNF423 BCL2 MAP3K7 MAPK12 MAP2K2 RRAS2 PMC8949786__F6 Characterization of Accessible Chromatin Regions in Cattle Rumen Epithelial Tissue during Weaning KRT18 VEGFC HEL113 CREB5 NFKB2 TNFRSF1A PIK3R2 PIK3R1 MYC NCK2 RAC3 CTNNB1 ITGB6 PIK3R4 ITGB8 MYH9 MAPK12 ATF4 CCND1 HEL-S-15 MAPK1 ACTN1 MYL6 FLNB MYH10 PARVA FBLIM1 RHOT2 FOS RHOU RICTOR ITGB1 ACTN4 PPP2R2A MAPK10 LEF1 PS1TP5BP1 PMC3148591__F2 Major signaling pathways of IPC- and Ipost-mediated protection against cardiac cell death STAT3 PMC8204759__F1 Golgi-localised components that mediate mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) signalling RHEB GOLPH3 RAB1A ARF1 PMC3204848__F13 Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane COX1 PLCG2 PMC6470053__F8 Nature and nurture: Confluence of pathway determinism with metabolic and chemical serendipity diversifies Monascus azaphilone pigments RC3H1 H1-5 H1-1 H1-3 PMC3341711__F1 TGFB/Smad canonical signaling pathway TF SMAD2 SMAD4 TGFBR1 PMC6470053__F9 Nature and nurture: Confluence of pathway determinism with metabolic and chemical serendipity diversifies Monascus azaphilone pigments RC3H1 H1-5 H1-1 PMC9485288__F8 G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction ANKRD1 G3BP2 VCAM1 PMC8832959__F1 Cancer metabolism and dietary interventions ACLY KHK GOT2 HEL-S-133P HK2 MAL ME1 ACSS2 ACAT1 BCAT2 BCAT1 HEL-S-32 CIT PMC6001654__F1 Role of DKK4 in different signal pathway NR1i1 CD44 DKK4 GSK3B CCND1 CTNNB1 MAPK3 PMC8096907__F2 miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune Diseases SOCS1 STAT3 SMAD2 SMAD4 IL21R SNIP1 SOCS3 IRF4 IL23R PMC7845572__F2 An overview of cellular metabolic pathways in MM cells HEL-S-133P HK2 PTEN PMC7879452__F6 In nucleus, Lnc-BTG3-7:1 co-regulates the transcription of C21ORF91 gene with nuclear synergistic transcription factor JUND JUND GSK3B GRB2 CTNNB1 EURL PMC8002431__F4 Gene networks regulating flowering time showing differentially expressed genes in cid3cid4 PRR5 EFL1 PRR9 ELF4 PRR7 ELF3 CAT56 PMC8311559__F1 Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases STAT3 APC FOXP3 MTOR IL1B PMC6944118__F8 Working model of the role of HERC2 in p53‐MDM2 loop regulation HERC2 ATR ATM MDM2 NEURL4 PMC3742228__F2 Schematic overview of Hedgehog signaling and rationale for combination therapy with (chemo)radiotherapy SUFU PTCH1 SHH PC ATM SMO MMP9 ABCG2 ABCB1 CTNNB1 GLI3 PMC7226770__F3 Blood–brain barrier, theoretically a motorway for a melting-pot of EXOs RAB27A RAB27B CD46 PMC2770887__F1 ER stress-induced signaling pathways that mediate autophagy ATG12 EIF2D MTOR ATG5 PMC4110175__F5 LDN Inhibition in TGFB Signaling Pathway adapted from KEGG 04350 BAMBI IFNG RBX1 SMAD1 DKFZp781O1323 SKP1 TGFBR1 PMC5047918__F2 Simplified view of B HEL-S-133P PTS LDHB PMC4110175__F2 SP600125 and BCI Inhibition in MAPK Signaling Pathway adapted from KEGG 04010 MAX NGF JUNB EGFR GCK INS PMC8604912__F7 Molecular mechanism by which Lactobacillus spp. regulate the core fucosylation of epithelial cellsthrough the Wnt pathway FUT8 WNT3 CTNNB1 PMC8353313__F6 Coeloglossum viride var. bracteatum extract attenuates staurosporine induced neurotoxicity by restoring the FGF2-PI3K/Akt signaling axis and Dnmt3 DNMT3B CASP3 FGF2 CP PMC4444401__F6 Function of the Chondrocyte PI-3 Kinase-Akt Signaling Pathway is Stimulus Dependent STAT3 IL1R1 OSM OSMR IRS1 IL1B PMC9117016__F9 Wheel-Running Exercise Protects Ovariectomized Mice from Bone Loss via IFN-Gamma-Mediated Suppression of the NFKB and MAPK Pathways CTSK NFATC1 TRAF6 PMC9185832__F1 Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes IFNG IL18 MYD88 PMC7947359__F2 BPs in the macrophage polarization STAT1 NLRP3 PMC7195796__F6 Effect of P17 reovirus on cancerous signaling pathway CDC2 TPR CDK6 CDK2 PTEN CCND1 PMC4100983__F4 Vemurafenib and panitumumab combination tailored therapy in BRAF-mutated metastatic colorectal cancer EGFR IGF1R MTOR PMC4859317__F1 Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan HEL-S-162eP GSK3B IL6 MTOR TNF PMC4440397__F1 Calcium channels in T cells PLCG1 STIM1 APC PMC4678629__F2 Classical pathways of type I IFN induction and HCV mediating IFN resistance STAT1 MAVS TLR3 STAT2 IRF3 TYK2 PMC9496732__F3 Regulating the Expression of HIF-1A or lncRNA: Potential Directions for Cancer Therapy CDH2 PMC10990278__F1 The Wnt signaling pathway RNF43 PORCN APC AXIN1 LRP5 ZNRF3 LRP6 CTNNB1 PMC8438241__F7 Sec62 Regulates Endoplasmic Reticulum Stress and Autophagy Balance to Affect Foot-and-Mouth Disease Virus Replication UVRAG XBP1 SEC62 PMC6708269__F1 Metabolism and Redox in Pulmonary Vascular Physiology and Pathophysiology HEL-S-162eP PRX PMC5745708__F9 PMSC differentiation into skeletal muscle using the insulin-like growth factor system MYOG IGF1 SOX2 MTOR IGF2 IGFBP6 IRS1 PMC7408912__F4 Scheme presenting the major proteins of the DNA damage response (DDR) signaling pathway and the miRNAs that interact with them H2AX ATM PMC7408912__F5 MiRNA regulation of homologous recombination (HR) repair factors after IR RAD52 RAD51 H2AX BRCA2 ATM PALB2 PMC3904625__F8 Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation ANKRD26 FLI1 RUNX1 TPO PMC8232085__F4 Polyphenol Supplementation Reverses Age-Related Changes in Microglial Signaling Cascades TCIRG1 RAN S100A8 PRPF8 CTSS C1QB CTSZ ALB IFNG HEL-S-99n UBA2 STAT1 HSPD1 ALOX5 PSME2 H2AC21 ABCB1 INPP5D PGAM1 DDB1 HEXA HSPA4 HSD17B4 ZYX PSMB2 YLPM1 C4A AKR1B1 CTNNB1 COL1A1 HEL-S-2a FKBP1A C4B_2 IL1B HSP90AB1 PDIA4 HNRPA3 FASN HEL-S-89n FGF2 PARP1 FTH1 THOP1 ITGAM MTDH HEL-S-125m ERAP1 HMGA1 HEL-S-130P PMC5823630__F6 Anti-estrogens mitigate mTORC1 inhibitor-induced activation of PI3K/AKT IGF1 INSR IGF1R IRS1 PMC4390903__F2 DNA damage pathways and how CHK1-, WEE1-, or CDK1 inhibitors can synergize with cytarabine to increase its DNA damaging efficacy in AML CDC2 HUS1 ATR RAD50 MYT1 SSB RAD1 MRE11A RAD17 WEE1 CDK2 ATM MDM2 PMC6245348__F6 Molecular network and proposed mechanism of activity.Notes: (A) The predicted mechanism for the reversal of cell survival, angiogenesis, and inhibition of apoptosis BAX BAD CASP8 EGFR PTEN MTOR VEGFA PMC4622404__F2 N-Glycan biosynthetic pathways in induced pluripotent stem cells (iPSCs), iPSC-derived cardiomyocytes, and human cardiomyocytes MGAT3 ST6GAL1 ST3GAL3 PMC10935410__F4 Protein-to-protein subnetworks involved in prolactin, leptin, BDNF, and neurotrophin signaling pathways in CD4+ lymphocytes STAT3 BAD RAF1 SHC1 GSK3B PIK3R1 MTOR FYN STAT5B CHUK SRC CCND1 HEL2 YWHAG BAX PTPN1 NTRK2 PTPN11 VAV1 NCOA1 PTPN6 IRS1 HRAS NFKB1 RELA ERBB2 BCL2 GRB2 BDNF SYN1 YWHAZ PMC8599049__F8 Interleukin 6 trans-signaling increases prostaglandin E2 production in human granulosa cells SOCS3 IL6 PTGS2 PMC312710__F8 RegA regulation by differential degradation UBC SKP1 PMC5961063__F1 Summary of ROS modulation during ECM detachment CD44 TXN FAS GCLM GCLC PRODH HEL-S-26 HEL-S-44 PMC8639021__F3 Neurobiology of COVID-19: how can the virus affect the brain? TMPRSS2 TLR3 TIRAP TLR4 IRF9 IRF3 TLR7 TRAF6 ACE2 IRAK4 MYD88 PMC9323154__F1 Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential BAX BAD FAS FADD PMC5584049__F6 AC6 and AC6-ΔN signaling CAV3 STAT3 SRC PMC5821947__F1 Regulation of expression and functional role of CD38 IL16 PMC4643957__F9 Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States BMP4 LRP5 LRP6 PMC11914587__F10 TGFB signaling TGFBR2 SMAD2 TGFBR1 PMC8763503__F8 STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway NR1i1 PMC5359955__F2 Title: In PI3K-Akt-mTOR signaling pathway, PI3K inhibits autophagy via activation of Akt RHEB TSC2 TSC1 MTOR PMC6094490__F1 Toll-like receptor (TLR) signaling pathways TBK1 TLR1 TLR3 TLR4 TLR9 CD14 TLR5 IRF3 IRF7 TLR7 MYD88 PMC11914587__F14 Mitophagy in neurons STAT3 SIRT3 ATG12 PMC4127946__F9 Proposed model for the role of CD28, CTLA-4, CD80, and the PD-1/PD-L pathway in mice after ischemic stroke CD80 APC PMC7047153__F1 Innate immunity and antiretroviral activities IRF7 MYD88 PMC11914587__F11 Interactions between astrocytes, microglia and neurons leading to neuroinflammation NLRP3 CD14 IL1B HEL-S-44 PMC3785965__F4 p120catenin regulation of Rho-GTPase signalling CDC42 VAV2 ARHA PMC8970045__F3 Full Functional Sex Reversal Achieved Through Silencing of MroDmrt11E Gene in Macrobrachium rosenbergii: Production of All-Male Monosex Freshwater Prawn UFD1L RHEB SVIP OS9 TSC2 RBX1 TSC1 CDC20 SEL1L SKP1 MTOR PMC8970045__F4 Full Functional Sex Reversal Achieved Through Silencing of MroDmrt11E Gene in Macrobrachium rosenbergii: Production of All-Male Monosex Freshwater Prawn PCNA CDK2 WNT4 PMC7287096__F5 Schematics of trafficking deficits mediated by pathogenic LRRK2 or knockdown of Rab8a RAB8A LRRK2 EGFR PMC9070300__F2 Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer’s Disease: Possible Therapeutic Role of KV1.3 Channel Blockade FYN NLRP3 TLR4 IL1B PMC7287096__F4 Schematics of EGFR degradation and recycling assays EGF RAB8A EGFR PMC7924360__F1 Modification of PtdIns Mediated by PI3K, PTEN, SHIP, INPP4 and the PI3K signaling pathway in cancer: The phosphorylated state of inositol lipids inserted in the cell membrane is controlled by inositol kinase and phosphatase enzymes PI3 PTEN PMC2975490__F1 Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis APC ROR2 LRP5 LRP6 RHO NLK CTNNB1 PMC9284871__F7 Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4 RPE NEDD4 MSC PTEN PMC4349708__F3 Mining Host-Pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms CDC42 CAV2 BAD VASP FLNB PARVA HEL-S-28 PTEN ARHA FLNA ITGAV HEL114 FYN BIRC2 LAMA3 PMC8039192__F2 Molecular mechanism of the Hippo signaling cascade LATS1 LATS2 PMC8039192__F3 Mechanism of the lncRNA-mediated regulation of Hippo pathway in cancer LATS1 FRMD6 LATS2 AMOT EZH2 PMC4083090__F7 A model of the role for ATRIP SUMOylation in the ATR pathway TOPBP1 ATR ATRIP PMC8912926__F7 Potential regulatory network of androgens and progestins regulating testis organization and spermatogenesis via Insl3 CYP17A1 INSL3 PMC7564391__F5 Major lncRNAs involved in taxane resistance SIK2 BCL2 AAG1 CDK4 PMC2929310__F3 Transcript abundance patterns in Kawasaki disease patients with IVIG resistance CEBPE CEACAM1 ASB3 SCARB1 TNFRSF9 AGER CYBA AMH TNF PMC8310668__F9 Proposed schema of AZ, SFN, and AZ+SFN targeting the pro-survival pathways in BC KEAP1 PC SFN PMC8501670__F3 Caenorhabditis elegans as a model for obesity research FAT4 FAS FAT1 FAT3 PMC4792095__F1 Inhibition of guanylate biosynthesis enzymes limits tumor invasion and growth IMPDH1 IMPDH2 GMPR PMC2929310__F6 Transcript abundance patterns in Kawasaki disease patients with IVIG resistance MAX ATF2 TNF PMC11462682__F2 Hexosamine biosynthesis pathway and cardiac function OGA OGT OPA1 PMC8591138__F6 Identification of Cross-Pathway Connections via Protein-Protein Interactions Linked to Altered States of Metabolic Enzymes in Cervical Cancer AURKA FUS TBK1 RFC4 NASP CDC20 CDC6 GSK3B VTN DNM3 TYMS MTOR CCNA2 FLNA MPO MDM4 BCL2L1 RBBP4 CDKN2C FKBP1A BUD31 HEL-S-66 CDK4 HEL-S-67p PER1 PLAUR MIF TNF PROX2 RICTOR CROP FZR1 ZRANB2 NONO TLR3 HSPA4 MCM3 CREBBP RFC3 TRAF2 PMC6770969__F6 KEGG AMPK signaling RHEB TSC2 FAS INSR POC1A F2 CFTR ACD MTOR INS PMC2994033__F1 Signaling complexes are induced by TNFA to mediate NFKB activation, apoptosis, and necroptosis TRADD CYLD TRAF2 FADD PMC9187215__F1 Dysregulation of Type 1 Interferon Signaling in Systemic Sclerosis: a Promising Therapeutic Target? STAT1 STAT2 IRF9 SMAD2 IRF7 IRF8 JAK1 TYK2 PMC2775888__F2 Cellular mechanisms by which flavonoids and their metabolites protect against neuroinflammation and neuronal injury induced by 5-S-Cys-DA, DHBT-1 and related ROS IFNG STAT1 BAD PMC9187215__F2 Dysregulation of Type 1 Interferon Signaling in Systemic Sclerosis: a Promising Therapeutic Target? STAT1 STAT2 IFNAR2 PDC JAK1 TYK2 PMC9099786__F2 Dissecting the Functional Role of the TRIM8 Protein on Cancer Pathogenesis IFNG STAT3 TRIM8 JAK1 PMC6889432__F5 Notch, PI3K, TGFB, Wnt/B-catenin, and EGFR/Ras signaling pathways are interacting with each other EGFR SMAD2 APC GSK3B SMAD4 PTEN GRB2 MTOR KRAS PMC7147523__F4 CD11c+ microglia as a subset of microglia present through life and across conditions CSF1 SIRPA ATM CD47 PMC4592238__F10 Small Molecule DAM Inhibitor, Pyrimidinedione, Disrupts Streptococcus pneumoniae Biofilm Growth In Vitro PTS GIP TBP PMC5980750__F1 Hippo-Yap signaling in ocular development and disease LATS1 RUNX1 PATJ AMOT RUNX2 PMC8386298__F2 Moving Towards Targeted Therapies for Triple-Negative Breast Cancer PTEN MTOR PMC6889432__F1 EGFR and PI3K signaling pathways in CRC RHEB ELF4 EGF TSC2 TSC1 EGFR PTEN GRB2 MTOR MYC PMC6889432__F2 Notch signaling pathways in CRC VWF MIB1 ADAM10 PMC10040549__F1 Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications TF FER STEAP3 LPCAT3 FACL4 PMC5241340__F8 Hypothesis of miR-567 modulation in healthy and BC cells SMAD2 SMAD4 PMC9576411__F2 Oxidative Stress and Intervertebral Disc Degeneration: Pathophysiology, Signaling Pathway, and Therapy NLRP3 KEAP1 COX2 PMC7226482__F2 Caspase-dependent and -independent apoptosis pathways utilized by cytotoxic T-cells (CTLs) and NK-cells and mechanisms of bone marrow microenvironment-mediated immune resistance STAT3 BAX HGF IGF1 MSC TNF NDUFS3 SET FADD PMC8007632__F7 Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGFB1/SMAD2/3 pathway and ABCC1 transactivation TGFB1 ATF4 TGFBR1 PMC3823134__F2 Schematic pathway of different steps of autophagy ATG12 ULK1 BCL2 MTOR PMC1410736__F1 Disposition of 17Beta-estradiol (E2) and metabolites UGT1A1 SULT1A1 PMC8641993__F1 Signaling Pathway of PGE2 and Its Regulatory Role in T Cell Differentiation COX1 PMC8988245__F2 Endoplasmic Reticulum Stress of Gut Enterocyte and Intestinal Diseases MFN2 ATF4 XBP1 PMC3756827__F1 Sirt3 deacetylation targets, and regulation of Sirt3 expression and activity SIRT3 HEL-75 PMC9006951__F2 Alzheimer’s Disease: An Update and Insights Into Pathophysiology GFAP GRID2IP PLG MMP3 MMP9 COX17 PMC5509684__F7 Statistically differentially expressed genes GALNT3 IFNG OGT FUCA1 MGAT4A MGAT3 RELA GCNT3 REL GCNT1 PMC9006951__F1 Alzheimer’s Disease: An Update and Insights Into Pathophysiology FGF7 GRB2 FGFR2 PMC419935__F8 A working model for the CblSTR signal transduction pathway CBLC CP PMC9589357__F4 Transcriptome analysis of malate-induced Schizochytrium sp. FJU-512 reveals a novel pathway for biosynthesis of docosahexaenoic acid with enhanced expression of genes responsible for acetyl-CoA and NADPH accumulation SDHA FAS HEL-S-162eP PC CS ME1 PMC11668798__F2 Sphingolipid rheostat targeting in adult-type diffuse gliomas CERS3 CERS5 SGPL1 CERS1 SGMS1 CERS2 SGMS2 SMPD1 KDSR SGPP2 PLPP3 SGPP1 PLPP2 PLPP1 PMC12027064__F2 The microbiota-induced expression of MMPs during OSCC PEAR1 CXCL2 IL8RB PMC12027064__F3 Microbiota-induced expression of MMPs in ECM remodeling during IBD and CRC IL10 TLR4 TNF PMC11720488__F1 Dysregulated Signaling Pathways in Canine Mammary Tumor and Human Triple Negative Breast Cancer: Advances and Potential Therapeutic Targets HOXB5 EGFR TINAGL1 PTK7 PMC11720488__F2 Dysregulated Signaling Pathways in Canine Mammary Tumor and Human Triple Negative Breast Cancer: Advances and Potential Therapeutic Targets PRR5 RICTOR PTEN MTOR DEPTOR PMC4428393__F2 Cytoplasmic folate-mediated one-carbon metabolism is required for de novo purine, thymidylate, and methionine synthesis MTHFD1 PMC1481516__F2 Metabolic pathway and bioenergetics of net citrate production in prostate cells MAL CS CIT PMC9278000__F2 Recent clinical findings on the role of kinase inhibitors in COVID-19 management BTK NLRP3 ACE2 IL1B PMC8946707__F1 Understanding the Notch Signaling Pathway in Acute Myeloid Leukemia Stem Cells: From Hematopoiesis to Neoplasia NOTCH2 NOTCH3 NOTCH1 PMC6067656__F1 Schematic representation of human adrenal steroidogenesis POR HSD3B2 CYP21A2 SRD5A2 HSD17B3 PAPSS2 CYP17A1 CYP11A1 PMC11790428__F1 Signaling pathway of NOD1 ATG16L1 IRF7 NOD1 TRAF3 RHO IL1B PMC7439808__F6 Reductive Glutamine Metabolism and Serine-Driven Folate Metabolism Suppresses Mitochondrial ROS Accumulation to Support Anchorage-Independent Growth and/or Metastatic Disease MTHFD2 MTHFD1 MTHFD1L HEL-S-51e HEL-S-26 PMC8440421__F5 Chitosan-mediated cGAS-STING and inflammasome activation, and the promotion of Th1 responses IFNG TBK1 CGAS NLRP3 IRF3 IL1B PMC4891098__F6 WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in human oral squamous cell carcinoma cells VEGFC HEL-S-28 PMC8909980__F6 Inflammatory Cytokine Production in Human Monocytes by cGMP and IRAK3 TLR4 IRAK3 RELA IRAK1 IL6 TRAF6 TNF IRAK4 MYD88 PMC8992488__F2 Glioblastoma chemoresistance: roles of the mitochondrial melatonergic pathway PDC AANAT AHR GSC CYP1B1 PMC6512043__F8 T10 inhibited NFKB activity via miR155-5p/SHIP1 axis CSA2 TLR1 IL16 TLR4 TRAF6 PMC10572156__F7 Beta-Sitosterol Suppresses Lipopolysaccharide-Induced Inflammation and Lipogenesis Disorder in Bovine Mammary Epithelial Cells BAX SCD FASN MTOR TNF PMC11015656__F1 Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review EGF HGF EGFR PTEN HIF1A RHO SRC HEL-S-26 DEPTOR MGMT PMC175791__F10 Differential regulation of NFAT and SRF by the B cell receptor via a PLCG–Ca2+-dependent pathway CDC42 RHD SYK BTK BCR LYN PMC3979452__F4 MiRNA regulation of skin fibrosis in epithelial and fibroblast cells SMAD2 SMAD4 PTEN ZEB2 PMC11015656__F2 20S proteasome inhibitors and their targets E2F4 CDK2 CCNB1 TNF CDK4 PMC8834318__F4 Cisplatin Resistance in HPV Negative Head and Neck Squamous Cell Carcinomas LOX ITGB1 PMC3298845__F1 Wnt/Beta-catenin signaling pathway in liver biology and disease APC LRP5 LRP6 CTNNB1 PMC6599650__F1 Schematic illustration of the formation of pH- and redox-responsive, methotrexate-loaded, APP-derived micelles via self-assembly in aqueous solution MMP2 APP MMP9 PMC9626535__F10 MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome BAX GPX4 BCL2 PMC400410__F5 Functional associations of genes identified by discriminant function analysis (DFA) in patients with juvenile rheumatoid arthritis (JRA) who were undergoing treatment TGFB1 FTL IL1RN CLU SLC2A3 INS CD63 NFIL3 PMC400410__F3 Functional associations of genes selected as differentially expressed in patients with juvenile rheumatoid arthritis (JRA) and normal controls PLN B2M TNF INS NPAT CAT56 IFNG CBL FPR1 CASP3 APP MX1 SRC PMC400410__F4 Functional associations of hypervariable (HV) genes in patients with juvenile rheumatoid arthritis (JRA) RANBP2 IFNG MYOD1 TGFB1 HEL-S-130P FUT2 ZNF263 DAP HLA-C TNF HLA-A PMC5932495__F2 The role of inflammasomes in Parkinson's disease and Alzheimer's disease CDK5 NLRP3 IL16 NLRP10 MYD88 PMC5463201__F2 Endogenous sources and consequences of ROS overproduction NOX5 NOX3 DUOX1 DUOX2 NOX4 PMC5463201__F3 Examples of NOX signal transduction STAT3 NOX5 MMP2 NOX4 EIF4E PMC1804347__F4 Systemic sclerosis: a prototypic multisystem fibrotic disorder CDC42 EGR1 MAP3K7IP1 SP1 RHO RAC1 TGFBR1 PMC10987301__F3 visually outlines the RAS/microRNAs (miRNAs) pathway in cancer metastasis, emphasizing the pivotal role of the Ras signaling pathway, particularly in tumor initiation and metastasis RASSF1 GRB2 PMC8166856__F7 STAT3 in gefitinib resistance STAT3 EGFR SRC PMC7490765__F5 Molecular basis of drug resistance in cancer ATR IGF1 EGFR ATM MTOR SRC PMC3438084__F6 A subset of the up-regulated genes with known function in response to maize root exudates HEL60 PTS PMC4193161__F8 A simple model was constructed on the basis of transcriptome data ERF PC RGR BAK1 PMC6695670__F2 Toll-like receptor (TLR) signaling TBK1 TIRAP MAL TLR9 TLR5 IRF3 IRAK2 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 TLR10 PMC5983921__F3 Wnt/Beta-catenin signaling pathway APC LRP5 ZNRF3 EP300 TEF CTNNB1 PMC8585982__F1 CAR-T: a potential gene carrier targeting solid tumor immune microenvironment CD80 PMC5412337__F1 Current strategies for targeting the epidermal growth factor receptor (EGFR) pathway STAT3 EGF HGF MTOR PMC8748960__F4 Training associated alterations in equine respiratory immunity using a multiomics comparative approach IFNG BAX MAK IRF9 PIAS1 IRF1 TYK2 PMC8497895__F2 Harnessing DNA Repair Defects to Augment Immune-Based Therapies in Triple-Negative Breast Cancer CD80 ATR CGAS APC ATM CTLA4 PMC11794105__F1 Signaling pathway regulating EMT in epithelial cells JUN SMAD2 APC CTNNB1 PMC8497895__F1 Harnessing DNA Repair Defects to Augment Immune-Based Therapies in Triple-Negative Breast Cancer CDC2 ATR ATRIP RAD51 BRCA1 WEE1 ATM SSB PMC4158168__F6 Signaling pathway that metformin uses to regulate T cell and osteoclasts in autoimmune arthritis STAT3 MTOR TRAF6 PMC7483800__F3 SARM1 Axon Degeneration Pathway: Control of the NAD+ Metabolome Regulates Axon Survival in Health and Disease NRK NAPRT SARM1 NAMPT PMC7831909__F2 Sulforaphane targets Nrf2 pathway to prevent kidney disease progression KEAP1 NQO1 VCAM1 AKR1C1 PMC7483800__F1 SARM1 Axon Degeneration Pathway: Control of the NAD+ Metabolome Regulates Axon Survival in Health and Disease SARM1 NMNAT2 SKP1 STMN2 PMC6492912__F1 The nicotinamide adenine dinucleotide (NAD) biosynthetic pathways in mammals NRK NAPRT NAMPT PMC3721034__F2 MDM2-p53 pathway revisited BAX HIPK2 ATM E4F1 TIGAR SCO2 PMC10991944__F1 Metabolic engineering of methylotrophic Pichia pastoris for the production of Beta-alanine MAL ASPDH ASPA CIT PMC11670207__F6 Identification of key genes related to growth of largemouth bass (Micropterus salmoides) based on comprehensive transcriptome analysis MAPK1 STAT3 PPARG JUN PER2 LEPR PIK3R1 ASPA MAPK3 CDKN1A FOXO1 HEL-S-162eP RELA BOK JAK1 SIRT1 PMC3721034__F5 MDM2-p53 pathway revisited RNF2 HIPK2 PML RYBP JMY MDM2 RPL26 PMC11670207__F7 DEGs in growth-related pathways PCK2 STAT3 FOXO3B SOS2 IKBKB PIK3CD PIK3R1 GRB2 MTOR JAK1 PCK1 RRAS2 PMC11659141__F4 Complement and coagulation genes are differentially expressed in head kidney samples between A CD59 C7 HEL-S-62p CS PMC3066048__F1 Complementation of Saccharomyces cerevisiae coq7 Mutants by Mitochondrial Targeting of the Escherichia coli UbiF Polypeptide COQ3 COQ2 COQ6 COQ5 PMC5165248__F1 Simplified schematic depiction of a hypothetic PrPc-induced signaling cross-talk between PI3K/Akt and Wnt/Beta-catenin pathway under hypoxic conditions EGR1 HEL-S-133P GSK3B PRNP CTNNB1 PMC7603558__F6 Signaling pathways involved in the actions of the 12 herbs against OvCa CD40 FAS TLR4 PMC2687355__F7 The signaling pathway MyD88 ⇒ p38 ⇒ EGR-1/AP-1 is essential for GBS-induced transcriptional activation of TNF EGR1 MAL PMC8110832__F3 Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer NAMPT SLC5A8 SIRT1 MEF2C PMC8110832__F1 Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer HK2 HEL-S-162eP EGFR PCK1 CTNNB1 PMC2637482__F2 Crosstalk between Robo4/Slit2 and VEGF signaling pathways SLIT2 RAC1 ROBO4 PMC6485244__F2 NFKB-BRD4 signaling in innate inflammation and remodeling BRD4 SNAI1 RELA IRF7 IL6 PMC7503576__F1 Bile acid synthesis pathways CYP8B1 CYP7A1 GCA CYP7B1 CYP27A1 PMC8045781__F2 Oncogenic RAS-dependent control of cellular metabolism RPE GOT2 RPIA GLS COX2 GPX4 HK2 FASN GFPT1 ENO1 ME1 KRAS PMC5406893__F7 Summary of the survival and growth phenotypes in breast cancer BAD RAF1 EGFR MCL1 IGF1R MTOR KRAS PMC5790481__F13 Melatonin attenuated brain death tissue extract-induced cardiac damage by suppressing DAMP signaling HMGB1 TLR4 MAL IL18 CD14 ME1 IL1B MYD88 PMC11682973__F1 The PI3K/AKT/mTOR signaling pathway ATG101 RHEB TSC2 TSC1 FOXO1 ULK1 FOXO3A F3 PTEN ELF3 IRS1 PMC7692672__F1 Synthesis and metabolism of sphingolipids (SLs) GLS tmp_locus_29 PC PMC9465647__F1 Resveratrol on rheumatoid arthritis: From bench to bedside KEAP1 RELA FOS SIRT1 PMC7736467__F6 Cannabinoid signaling pathways affecting neuronal extension length STAT3 BRCA1 ARHA SRC PAX6 PMC9125579__F10 Contribution of Mitochondria to Insulin Secretion by Various Secretagogues HMFN0839 GPAT4 ORAI1 CD36 GPAT2 STIM1 TRPC1 GPR119 TG TRPM2 TRPM5 SNAP25 TRPC3 PMC5078498__F1 Dopaminergic miRNA nodes in a rich network of connections in synaptic plasticity pathways PRKAG2 CHP1 PMC7082880__F5 Drugs targeting Wnt pathways in cancer treatments RNF43 LRP5 ZNRF3 PTK7 LRP6 GPR49 CTNNB1 PMC11576406__F4 Pathways significantly affected by shear stress in HBMECs(A) Effects of physiological shear stress (1 CD226 CD40 CXCL9 PLN CXCR3 TNC CXCL12 CXCL5 CXCL1 CXCL8 CD99 CXCL3 TRDN JAM2 CD58 HRC GLG1 BCR PI3 ICAM2 CAV3 CAV2 CXCR6 CD2 ESAM CXCL13 ICAM3 ITGA4 SELL ITGB7 SELE CXCL16 CXCL2 CXCL6 CXCL10 PECAM1 CD34 CXCL11 ITGAM CXCR1 ITGB1 TFEB CXCR5 MCU IL8RB CXCR4 SELP PMC7082880__F2 Wnt signaling pathways CDC42 MUSK STAT3 JUN APC GSK3B PTK7 RYK ATF2 RHO CTNNB1 LATS1 LATS2 FYN RNF43 TEF PMC11576406__F6 Pathways significantly affected by iRBC exposure in HMBECs(A) The endosomal signaling pathway was affected by co-incubation with ring stage iRBCs and shear stress (1 SNX12 CDC42 EHD2 CXCL9 CXCR3 VTA1 EHD3 RAB10 CXCL12 CXCL1 SMAD2 ARF6 SNX5 CXCL8 CD99 CHMP3 CXCL3 VPS28 JAM2 CHMP6 VPS25 SNX4 LDLR SRC AMPH CXCR6 ESAM CXCL13 CXCL16 TSG101 CXCL2 ARHA CXCL6 CXCL10 SNX3 EEA1 PECAM1 CXCL11 VPS35 CXCR1 CAPZB CXCR5 SNX1 RAB35 IL8RB CXCR4 PMC6305747__F2 Pentraxins-expanded network of complement activation and regulation CRP PTX3 FH HEL-S-62p CP PMC7078296__F7 Helicobacter pylori-induced adrenomedullin modulates IFN-Gamma-producing T-cell responses and contributes to gastritis STAT3 RAMP2 ADM AGA PMC4369672__F1 Intracellular signaling proposed to be involved in the inflammatory response during immune-mediated joint diseases such as aseptic loosening HMGB1 TBK1 TIRAP S100A8 IL33 TLR9 IRAK1 TLR5 IRF3 IFI16 IRF7 TRAF6 IRAK4 MYD88 TLR1 NOD2 DDX41 NOD1 IFNB1 S100A9 IL1B PMC4369672__F2 Simplified overview of the RA-associated inflammation-promoting factors DKK3 SFRP4 WNT3A ROR2 IL1B PMC7163451__F8 Schematic diagram about the central role of co-treatment with Beta-elemene and cetuximab in ferroptosis induction and migration inhibition TF SLC3A2 SLC40A1 STEAP3 GPX4 SLC7A11 PMC8706759__F1 Targeting DNA repair pathway in cancer: Mechanisms and clinical application PNKP ATR PCNA PARG BRCA2 ATM SSB XPC PMC8706759__F3 Targeting DNA repair pathway in cancer: Mechanisms and clinical application ATR CGAS ATM IRF3 PMC11455816__F8 Schematic of MAGL blockade-mediated protection from GC-induced bone homeostasis imbalance LPL RUNX2 CTNNB1 PMC8618597__F5 Leucosceptoside A from Devil’s Claw Modulates Psoriasis-like Inflammation via Suppression of the PI3K/AKT Signaling Pathway in Keratinocytes MKI67 STAT1 DEFB1 S100A7 IF2B1 DEFB4B IL17A IL6 HP PTGS2 CCL2 CCL20 PMC8485741__F1 Induction and Evasion of Type-I Interferon Responses during Influenza A Virus Infection MAVS STAT2 IRF9 IRF3 IRF7 MYD88 STAT1 TRIM25 TLR3 TLR8 MX1 TLR7 ISG15 TYK2 PMC4172968__F11 Schematic representation of the signaling pathway proposed for the AhR-dependent control of cell migration CSK AHR SRC PMC10459054__F1 Typical pathway of miRNA formation RAN DGCR8 DROSHA PMC10459054__F4 Natural Products Treat Colorectal Cancer by Regulating miRNA PTBP1 MMP3 PMC10459054__F2 Anti-cancer mechanisms of five agents (1) resveratrol induces growth inhibition and apoptosis in colon cancer DLD-1 cells by reducing miRNA-96 expression through MAPK/ERK1/2 signaling pathway activation ERBB3 STAT3 BAX EGFR EVI1 GCNT3 MTOR PMC9254480__F1 VEGF/VEGFR-Targeted Therapy and Immunotherapy in Non-small Cell Lung Cancer: Targeting the Tumor Microenvironment CDC42 VEGFB VEGFC BAD FYN RAF1 MAPKAPK2 NRP1 NRP2 VEGFD MTOR VEGFA PMC9546106__F2 Neutrophil granule proteins in orchestrating inflammation and immunity SYK c-fgr TLR9 DOCK2 PMC4378458__F4 NAD+biosynthetic pathways NAPRT HEL-S-90n NAMPT PMC9666786__F1 Crosstalk between enteric serotonergic neurons and colorectal cancer stem cells to initiate colorectal tumorigenesis HTR1F HTR1B HTR1D AXIN1 TPH2 CCND1 CTNNB1 PMC11287639__F1 SMAD4 in the transforming growth factor-beta (TGFB) signalling pathway TGFBR2 BMP10 BMPR2 SMAD9 ACVR2B SMAD1 ACVR2A DKFZp781O1323 BMPR1A BMP4 BMP2 TGFBR1 PMC2778287__F6 Schematic representation of a dualistic model depicting the development of ovarian cancer BRCA1 EGFR BRCA2 BRAF PTEN KRAS PMC2678157__F9 The steroid synthesis pathway showing genes regulated in this study HSD17B3 STAR HSD11B2 HSD3B7 PMC6317954__F4 Metformin combined with Abs or small molecular inhibitors in cancer treatment IGF1 EGFR MTOR PMC3146784__F2 TLR ligands and signalling TIRAP TLR3 TLR4 TLR9 TLR5 IRF3 IRF7 TLR7 MYD88 PMC9437261__F7 Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice STAT3 FXR1 FAS MMP9 JAK1 PMC6317954__F1 General molecular mechanisms of metformin on inhibiting cancer cell growth IGF1 IGF1R MTOR PMC4691138__F1 Schematic presentation of proposed molecular epigenetic mechanism of sulforaphane’s action including interdependence between histone modification and DNA methylation PCNA CCND2 SFN PTEN PMC9299441__F8 Neutrophil Survival Signaling During Francisella tularensis Infection BAX BAD GSK3B PMC5382021__F6 Group B Streptococcus degrades cyclic-di-AMP to modulate STING-dependent type I interferon production TBK1 CGAS IRF3 PMC7565808__F1 Micropeptides encoded by lncRNAs regulate tumor malignant behaviorsa Linc00998 encodes micropeptide SMIM30 promotes HCC development by inducing SRC/YES1 membrane anchoring and MAPK pathway activation RPS6 STAT3 SMIM22 SP4 BPI SQLE IGF2 PMC8041881__F4 IL-17 signaling pathway USP25 TRADD ELL IL4 TRAF3 LCN2 REL FADD PMC11978694__F5 MiRNA in treatment of gout arthritis SOCS1 KLF2 EREG NLRP3 TLR4 NFAT5 ZEB2 VEGFA MYD88 PMC4306190__F4 Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview HMGB1 VCAM1 S100B PMC7139574__F1 Biological pathways involved in chronic lymphocytic leukemia (CLL) pathogenesis and harboring therapeutic implications CD40 FBXW7 BTK LTBR BCR PLCG2 RELB ATM TRAF3 TRAF2 BIRC3 PMC6549020__F1 cTAZ: a safeguard factor of antiviral response TBK1 STAT1 STAT2 IRF9 ACVR1C IRF3 FOXP3 PMC11978694__F2 Molecular pathways involved in gouty arthritis and potential miRNA regulators GSDMD NLRP3 TLR4 PTEN ARHA MTOR SIRT1 MYD88 PMC9663420__F6 P2RX receptors and inflammatory markers in SCZ P2RX7 P2RX4 NLRP3 SERPINA3 PMC3185489__F1 Diagram connecting the insulin pathway and fatty acid (FA) biosynthesis LPA FAS SCD MTOR IRS1 PMC7240781__F8 Crosstalk between the adrenal steroidogenic regulatory network and the immune pathway PGR GRN IL1B PMC5483452__F8 Schematic illustrating the role of Nupr1 in METH-induced apoptosis and autophagy in neuronal cells NUPR1 MTOR TRIB3 PMC8320172__F3 Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? EGFR MTOR ACE2 PMC7730574__F5 Anti-inflammatory activity of Ep-ME when targeting TAK1 in the AP-1 signaling pathway JUN TLR3 TLR4 IRAK1 IRAK4 MYD88 PMC6497798__F3 Targeting of host gene expression by Toxoplasma gondii SOCS1 CD40 STAT3 STAT1 EGR1 SOCS2 IRF4 PMC9589293__F2 Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses PNLIPRP2 IPO11 CGA ITIH6 ARFRP1 EGFR ANKS1A BCAS3 GSK3B C7orf21 COX7C SMAD4 AGTPBP1 RSAD1 MAP2 TBC1D8 ZNF12 ZNF135 ALB PNLIP HMOX1 UBA2 ALKBH5 MIB2 MAF RAG1 UBC MAP4 SCD BST1 hEMMPRIN CASP8AP2 ARHGAP29 NLRP1 DKK3 ARD1A HMGCR HTATSF1 MAP2K1 PMC9589293__F3 Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses DEF6 MYC TMEM41A KIF23 CTNNB1 AARS1 LARP1B FHAD1 CTCF TCEAL7 APOBEC3D WWTR1 TIGD4 ADGRV1 CHURC1 CD33 RNF24 PCDHA11 RBMXL1 POLR3B SRSF8 SPEG CCR8 CRB1 DGKG CYB5B HMGCS1 IFT22 TCF3 DPF3 CREBBP ABCD4 JARID2 IL10RB PMC9589293__F4 Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses ACLY CD59 GSTM2 MSMO1 SMAD2 FADS2 HBA2 MOK PLAT HEL-S-277 FOSL1 CYGB ADFP ChAT DYRK3 TMEM119 PMC5040224__F2 Major regulatory pathways involved in the regulation of Runx2, a chief transcriptional regulator of osteogenesis SMAD1 DKFZp781O1323 DKK1 BMP4 GSK3B BMP2 DKK2 RUNX2 LEF1 CTNNB1 PMC6497798__F1 Autophagy initiates host immunity and Toxoplasma immune evasion CD40 STAT3 EIF2A SRC PMC7504854__F3 Mechanism by which A20 regulates arthritis TRADD MLKL TAB3 TNF TRAF6 MYD88 RIPK3 GSDMD NLRP3 TRAF5 RIPK1 TRAF2 IL1B FADD PMC3185489__F4 The effects of HCV on steatosis development FAS NR1C1 SCD APOB PMC11755957__F8 Cellular response in bovine sperm after frozen-thawed NGF HEL-S-128m HEL-S-67p CLU PMC7640369__F6 Pathways in which radiosensitizing effects of c-myc gene knockdown induced G2/M phase arrest by intrinsic stimuli through the mitochondrial signaling pathway CCNB1 CCND1 PMC3185489__F2 Some of the effects brought about by HCV on insulin signaling in hepatocytes PKD1 MTOR IRS1 PMC8436723__F4 Screening a Prognosis-Related Target Gene in Patients with HER-2-Positive Breast Cancer by Bioinformatics Analysis DBF4 PCNA CDC6 SMC3 CDK2 CYC1 MCM2 SKP2 ORC2 PMC3605881__F6 Scheme of mechanisms underlying attenuation of cardiac dysfunction induced by endotoxin, after NG-R1 treatment TLR4 TRAF6 MYD88 PMC8012432__F1 Novel Method to Differentiate Tonsil-Derived Mesenchymal Stem Cells In Vitro into Estrogen-Secreting Cells CYP17A1 CYP11A1 STS PMC10487928__F4 Gamma interactome of the top 20 most connected differentially expressed genes (DEGs), defense response to virus genes, angiogenesis genes, adaptive and innate immune genes, and SARS-CoV-2 proteins CALD1 TGFA PTK6 EPHA2 HIST1H1E CCNA2 CCL2 H1-1 EPHB2 MX1 ISG15 SIGLEC10 DOK4 MARCHF8 JUP CDC2 H4C9 LGALS3BP SNCA hEMMPRIN OAS3 ID1 H2BC9 H2BC3 RIN1 ERBB2 MCM2 PMC6640647__F2 Simplified TGFB signaling pathways CDK2 NODAL ARHA MTOR MYC PMC8819604__F3 Pathophysiological Pathway Leading to the Development of Valve Calcification in Chronic Kidney Disease PCSK9 LPA PTH FGF23 PMC3830198__F4 Model showing the proposed mechanisms of lncRNA-mediated regulation of the RB pathway CDK6 CDK4 PMC3830198__F5 Model showing the proposed mechanisms of lncRNA-mediated regulation of the p53 pathway ATR ATM MDM2 PMC8132131__F4 Interplay between hydrogen sulfide and other signaling molecules in the regulation of guard cell signaling and abiotic/biotic stress response KIN PMC4369647__F2 Signaling pathway associated with CD37 ligation by SMIP-016 SYK CD37 GSK3B LYN CTNNB1 PMC11754069__F1 Intrahepatic network and metabolic signaling in NAFLD ACLY ACSS2 KHK MTTP XBP1 ERN1 PMC11754069__F2 Extrahepatic organ-specific networks associated with NAFLD FGF8A FGF21 POMC SPARC GIP NPY AgRP CYP7B1 PMC6460526__F2 CYLD-associated signaling pathways CDH2 JUN MAP3K7IP1 LTBR TRADD SUFU RELA RELB SMO CYLD TRAF2 CTNNB1 PMC10003241__F3 Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease COL1A1 GLS SLC7A7 SLC1A3 LRP5 LRP6 ASNS RUNX2 PMC4906788__F2 TGFB signaling pathway BAMBI LTBP1 IFNG THBS1 E2F4 FST SMAD4 SKP1 NODAL ARHA TNF PMC4755536__F7 De Novo Transcriptome Assembly and Characterization for the Widespread and Stress-Tolerant Conifer Platycladus orientalis PRR9 ELF3 CAT56 PMC7400738__F2 Biogenesis, secretion, composition, and application of exosomes as liquid biopsy CD81 CD9 TSG101 CD63 PMC7001864__F1 Molecular Control of Canonical WNT Signaling DVL1 RNF43 PORCN DKK1 APC NOTUM AXIN1 LRP5 ZNRF3 KREMEN1 GPR49 CTNNB1 PMC7001864__F3 Impact of WNT Signaling on Cancer Immunosurveillance IDO1 DKK1 BATF3 FOXP3 CXCL10 PMC10041388__F1 Metabolic reprogramming in cancer: Mechanisms and therapeutics PCK2 OGT HEL-S-133P HK2 ENO1 PMC6928102__F8 Proposed model of the EPHB2 signaling cascade that regulates the synaptic plasticity through the phosphorylation of AKT under neuroinflammation-associated perturbation of glutamatergic transmission EFNB1 GLS GAD1 BDNF PMC6905197__F1 Hippo signaling pathway LATS1 MOB1A PMC6928102__F5 Correlation network between the significantly changed metabolites and proteins of the hypothalamus in the LPS group compared with that in the CON group BORCS6 PGAM5 CRH HSBP1 ROBO1 CDC42EP4 LAMTOR2 PPIP5K1 EFNB1 NECTIN2 PTPRO EDC3 GRB10 ARHGEF17 PRKX ChAT SH2B1 PTPN4 JPT1 PMC9653955__F13 Phytocannabinoid Compositions from Cannabis Act Synergistically with PARP1 Inhibitor against Ovarian Cancer Cells In Vitro and Affect the Wnt Signaling Pathway RAD51 TRPV2 DKK1 F7 DVL2 CTNNB1 PMC3820524__F1 Overview of hemostasis TFPI APC PMC7072767__F4 PINK1-Parkin pathway regulates IPAS expression and inhibits neuronal death PINK1 PMC7356809__F3 FAT10 is expressed in response to RNA virus infection and acts as a negative feedback regulator of RIG-I activation MAVS IRF3 IRF7 TRAF3 TRAF6 TRAF2 PMC6237963__F6 Cell cycle regulation pathway and the genes whose expressions were altered by 11-KT STAG2 CDC20 PCNA CDC6 STAG1 SMC3 SMAD2 SMAD4 MYT1 SKP2 PLK1 CCNB3 CDK6 CDK7 CCND2 E2F4 MDM2 CCNB1 CDK4 CDC2 DBF4 UBC APC RBL2 ORC3 RAD21 CCNE2 CDC45 CDC25B PMC6022559__F6 Subnetworks of breast cancer subtypes PTPRM MSH6 PIK3CA EGFR PER1 CARD11 IBSP MYC KRAS SPOP ACVR1B PLCB1 TLN1 INPPL1 PMC5061729__F1 EGFR signaling pathway modified from MetaCore® PLCG1 CBL SHC1 NCK1 EGFR IGF1R GRB2 SRC PMC9009225__F5 Qinggan Huoxue Recipe Alleviates Alcoholic Liver Injury by Suppressing Endoplasmic Reticulum Stress Through LXR-LPCAT3 LPCAT3 ATF1 EIF2A XBP1 PMC8847441__F5 Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development HES1 RBPJ NOTCH1 HES5 PMC11050203__F1 Activated signaling pathways: (a) the Wnt signaling pathway is activated in the presence of Wnt APC LRP5 MDM2 MTOR CTNNB1 PMC8365519__F5 Low-Dose Radiation Can Cause Epigenetic Alterations Associated With Impairments in Both Male and Female Reproductive Cells SNRNP200 RHOB MYC POLE NACA FLNA PMC10974426__F1 Virus-activated intracellular signaling pathways STAT1 CGAS IFNAR2 IRF9 IFNAR1 IRF1 IRF3 JAK1 TYK2 PMC3962044__F1 NFKB signaling pathways in osteoclast lineage cells TAB3 RELB TRAF3 TRAF6 TRAF2 PMC3962044__F3 IAP antagonists and NFKB signaling in osteoclast lineage cells TRADD RELB RIPK1 TRAF3 TRAF2 PMC6260925__F6 Senescence prevention by HO‐1 activation PINK1 PMC7120155__F11 Antifibrosis therapy LPA FRK MTOR PMC5904200__F2 Simplified scheme of established complement activation pathways CRP CD59 FH C5AR2 C5AR1 HEL-S-62p C3AR1 C2 CD55 CR1 PMC7762936__F2 Post-translational regulation of the long and winding cholesterol synthesis pathway IDI2 EBP SC5D DHCR24 MVK LBR MARCHF6 HMGCR ACAT2 PMVK MVD DHCR7 FDPS IDI1 HSD17B7 PMC3171365__F2 Bayesian network fits for mutation data for cycle checkpoint II pathway using (a) Minimum Spanning Tree algorithm (maximum indegree of 1); (b) Bayesian Information Criterion (maximum indegree of 2) RB1 FANCG CCNE2 CDKN2A ATR CCNG2 CDC34 RBBP8 PMC3171365__F3 Bayesian network fits for wildtype data for cycle checkpoint II pathway using (a) Minimum Spanning Tree algorithm (maximum indegree of 1) RB1 FANCG CCNE2 CDKN2A ATR CCNG2 CDC34 RBBP8 PMC5807685__F1 Canonical hippo signaling pathway LATS1 MOB1A MOBKL1A LATS2 PATJ AMOT PMC9099564__F2 Glioma Stem Cells in Pediatric High-Grade Gliomas: From Current Knowledge to Future Perspectives BMI1 CD44 PTN SPARCL1 SOX2 SPARC OLIG2 RHO MTOR PMC6802183__F7 Model structure consists of HIF-1A signaling, tumor signaling, and ATP depletion modules AMN HEL164 EGF NF1 EGFR PTEN GRB2 PMC8352569__F3 DNA Methylation of PGC-1A Is Associated With Elevated mtDNA Copy Number and Altered Urinary Metabolites in Autism Spectrum Disorder FIS1 STOML2 OPA1 MFN2 NRF1 GABPA PMC8010885__F6 Cholesterol associated changes in cancer cells and available therapeutic targets ABCG1 NPC1L1 LDLR ABCA1 PMC10758146__F1 Lithium exerts neuroprotective effects in ischemic stroke through multiple mechanisms NLRP3 MTOR BDNF CTNNB1 PMC7597592__F9 Proposed model of how TNFA and RIPK3 induce KC death following PH RIPK3 RIPK1 IL6 CCL2 FADD PMC2918404__F8 Osteogenic Transcription Factor Runx2 Regulates Components of the Fibroblast Growth Factor/Proteoglycan Signaling Axis in Osteoblasts FGFR1 RUNX2 FGF2 PMC3555197__F1 LXRs and prostate physiology: potential beneficial actions of LXRs over prostate cancer ABCG1 BAD ABCG8 ABCG5 LDLR ABCA1 PMC11899595__F1 Key molecular mechanisms/rationales for targeted agents in mantle cell lymphoma (MCL) BAX CXCL12 SYK CD79A BTK IKZF1 BCL2 LYN MTOR CXCR4 CRBN IKZF3 PMC3567093__F6 Somatostatin Derivative (smsDX) Targets Cellular Metabolism in Prostate Cancer Cells after Androgen Deprivation Therapy GLUD1 ACAT2 ENO1 HEL-S-26 PMC6695833__F1 YAP1/Hippo and wild-type p53 pathways coordinately maintain genomic stability in response to stress LATS1 TF LATS2 MDM2 YAP1 PMC6695833__F2 Transcriptional co-ordination between YAP1/Hippo and p53 family proteins in tumorigenesis or apoptosis CDC2 BAX TP53AIP1 ACTL6A WWC1 PML MDM2 CCNB1 YAP1 PMC7582405__F5 Most significant IPA networks involving the proteins that were differentially regulated between the CF and control states SERPINC1 APOA4 CFI PMC5486846__F1 The extrinsic and intrinsic apoptotic pathways, as well as the inhibitory effect of various IAPs on pro-apoptotic molecules NAIP TRADD TNF FADD PMC8318865__F7 Expression characteristics of interferon-stimulated genes and possible regulatory mechanisms in lupus patients using transcriptomics analyses STAT2 PLSCR1 IRF9 IFITM1 IFIH1 IRF3 IRF7 MYD88 STAT1 TLR1 IFNAR2 TLR4 IFNAR1 PMC8576660__F2 Narrative review of emerging roles for AKT-mTOR signaling in cancer radioimmunotherapy STAT3 GRB10 GSK3B GRB2 SRC MYC PMC12197781__F6 Effect of Ad14 miRNAs on the NFKB signaling pathway CD40 ZAP70 TBK1 EGF LTA TNFAIP3 TIRAP TNLG7A CARD11 TAB3 GH1 TRAF3 TRAF6 MYD88 MAP3K8 NGF BTRC PLCG2 TNFRSF17 CHUK HDAC2 CASP8 TNF TNLG2B HDAC1 UBE2V1 HEL-S-71 MAP3K7IP1 RELA BMP2 TRAF5 TNFSF11 TRAF2 FADD LCK PMC9180607__F5 Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration SP1 HK2 SP3 CCN3 RFX1 CTGF YAP1 PMC8624704__F5 Long-Term Effects of Ionizing Radiation on the Hippocampus: Linking Effects of the Sonic Hedgehog Pathway Activation with Radiation Response NRG1 ADORA2A PTN PAFAH1B1 ALK PTCH1 CXCL1 SHH EP300 FGF2 PMC4412127__F1 Signaling pathway regulation of ΔNp63 STAT3 SUFU EGFR GSK3B IRF3 IRF7 CTNNB1 FGFR2 GLI3 PMC4551923__F8 Rad4–Rad23 and GG-NER E3 ligase function in DDR signalling and dNTP synthesis PMC7291293__F3 Summary of caveolae/CAV-1 in signal transduction during virus infection ARHA SRC RAC1 PMC8507004__F7 Promotion of chemerin in rat diabetic kidney disease through enhancement of TGFB1/Smads/CTGF pathway CCRL2 SMAD2 SMAD4 PMC4112878__F1 Endoplasmatic reticulum stress caused by saturated free fatty acids BAX BAD BIK PMC4506078__F4 Adaptation of a Bioinformatics Microarray Analysis Workflow for a Toxicogenomic Study in Rainbow Trout DBF4 BAD STAG3 CDC20 PCNA PGR LAT SMAD4 MYT1 INS ORC3 REC8 CDK6 IGF1 CDK7 MDM2 CDK4 PMC5077201__F6 Possible model of TIPE2 inhibition of activation of TAK1 signaling MAP3K7IP1 TRAF6 TRAF2 PMC7650600__F8 KIR2DL2/L3/S2+ CD8+ T cell cluster analysis of the protein-protein interaction (PPI) network with STRING database RPL35 TNFRSF1B NUP214 CCL3 EGFR IFIT3 RPL36 CCR3 SMAD4 HLA-DPB1 RPL37 TGFBR1 RPS27 IFNG CD58 RPS3A RPL17 HLA-F RPL29 WAS UBE2D3 ADCY6 RPL7 CCR1 RDX DNMT3B KCNC3 FBXO6 CD244 KIR2DL2 GTF2H5 NME7 IRF7 TAF15 RUNX3 CD44 RPS24 PRF1 CDKN1A EIF3J RPL36A FCGR3A FOXO3A ACVR1 MAP2K1 ZBTB16 FBXW4 HLA-A PMC9271773__F2 Targeting Adenylate Cyclase Family: New Concept of Targeted Cancer Therapy CAST VAV2 EBP ATM CTNNB1 PMC9002106__F3 Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials NLRP3 COIL TNF PMC5154531__F6 Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway NPR2 CNP NPRC PMC7697003__F4 FAK involvement in rhabdomyosarcoma TSC2 HGF IGF1 MTOR SRC PMC9271773__F5 Targeting Adenylate Cyclase Family: New Concept of Targeted Cancer Therapy EGFR MYC SIRT6 PMC4943290__F1 Agents acting on the renin–angiotensin system pathway ©PharmGKB MAPK1 BDKRB1 TGFB1 AGTR1 CTSG ATP6AP2 NR3C2 AGTR2 CMA1 REN MME MGRA ACE2 BDKRB2 PMC4877005__F3 Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure BSN ATP2B1 SYNJ1 PCLO ATP2B3 ANK2 ATP2B4 SYP ATP2A2 GRIN1 SPTAN1 PMC9096244__F2 Review: PI3K/AKT/mTOR Signaling Pathway and Its Regulated Eukaryotic Translation Initiation Factors May Be a Potential Therapeutic Target in Esophageal Squamous Cell Carcinoma CDKN2A FBXW7 EGFR ERBB2 AJUBA MTOR CCND1 PMC9096244__F3 Review: PI3K/AKT/mTOR Signaling Pathway and Its Regulated Eukaryotic Translation Initiation Factors May Be a Potential Therapeutic Target in Esophageal Squamous Cell Carcinoma RPS6 TSC2 BAD RICTOR PTEN MTOR IRS1 PMC4951461__F2 Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls TPH1 CRAT IDO1 PMC2668232__F5 Principles in TLR signaling TBK1 TLR4 TAB3 MAL TANK IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC1963413__F1 Oval of iNOS-inducing signaling pathways NAPA IL19 TLR3 ATF2 PMC3572009__F5 Dysfunctional Activation of Neurotensin/IL-8 Pathway in Hepatocellular Carcinoma Is Associated with Increased Inflammatory Response in Microenvironment, More Epithelial Mesenchymal Transition in Cancer and Worse Prognosis in Patients RGS2 TNC NTS HEL-S-43 THBS1 MASP2 F13B CCL15 SPHK1 CXCL1 HSD11B1 ITGA2 CCL20 TNFRSF11B KNG1 PMC9263829__F1 Can the cGAS-STING Pathway Play a Role in the Dry Eye? VCAM1 IL1B PMC3694976__F10 Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia CBL PIM1 EPO IL6 PMC4877005__F2 Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure ACTN1 ANK2 SPTBN2 EPB41L3 SPTBN1 ACTN2 CNP VCP NEFH NCAM1 ACTN4 PLEC AP2A2 SPTAN1 PMC4593313__F1 Cellular interactions in normal and diseased vasculature FGF7A FGFR1 VCAM1 RUNX2 FGF8 FGF2 FGF23 FGFR2 PMC204456__F5 Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans HEG1 EGFR CIRSR GRB2 PMC6887797__F1 TSC2 mediated crosstalk between the Akt/mTOR pathway and the cyclin D1-CDK4/6 axis.The cyclinD1/CDK4/6 axis is responsible for increased phosphorylation TSC2 and TSC1, and promotes the phosphorylation of the mTOR substrates, 4E-BP1 and S6K1 TSC2 CDK6 TSC1 EGFR MTOR CCND1 CDK4 PMC10845928__F1 Immunologic properties of cancer stem cells (CSCs) STAT3 CEACAM1 CSF1 HK2 TAP1 TCF4 MTOR CCL5 CHMP2A CCL2 CD47 CTNNB1 SOX9 SIRPA TAP2 TRIB3 PMC10845928__F2 Ferroptosis in CSCs SLC3A2 FTL GPX4 STEAP1 SLC7A11 CXCL2 CXCR4 PMC10845928__F3 Mechanisms underlying radio-resistance in CSCs STAT3 ATR RAD51 CCND2 ATG14 CDK2 ATM PMC10845928__F4 Mechanisms underlying chemoresistance in lung CSCs BMI1 ALDH2 ROCK2 PAK1 NFYA POLR3G ABCG2 HES1 NOTCH1 ABCB1 PMC7352359__F3 Current model of regulating the BRI1 abundance on the plasma membrane (PM) SNX1 FLOT1 BAK1 PMC3474103__F22 Diagram demonstrating the sites and mechanism of action of novel agents for the management of pancreatic endocrine neoplasm RAF1 EGFR MTOR PMC7232103__F1 Proposed mechanism for the synthesis of dihydroindoles from triazole 1a and rationalization of dihydroindole regioselectivity from sigmatropic rearrangements HEL70 PMC4043921__F4 Cytoskeletal proteins in cerebral cavernous malformation signaling pathways SMURF1 OSM MYH9 PDCD10 CCM1 MTOR PMC8560953__F7 Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells RAD18 REV1 PCNA POLN PMC4784227__F4 Heme biosynthesis pathway CPO UROD UROS PMC7072620__F1 HMGB1/RAGE and HMGB1/TLR4 signaling pathways in AD: HMGB1 can interact with extracellular AB peptides and decrease AB deposition by inhibiting AB clearance by microglia, as well as increasing Beta- and Gamma-secretase activity ACHE HMGB1 GSK3B IL1B PMC10838448__F2 RANKL/RANK signaling pathway activates NFATc1 PPP1R18 ANXA3 NFAM1 NFATC1 HIF1A TRAF6 PMC368161__F7 Interaction Networks in Yeast Define and Enumerate the Signaling Steps of the Vertebrate Aryl Hydrocarbon Receptor FUS PAF1 AHR SCO2 TWF1 SET PMC5354690__F1 FoxO1: a novel insight into its molecular mechanisms in the regulation of skeletal muscle differentiation and fiber type specification RHO MTOR MEF2C NOTCH1 PMC9710321__F1 Cannabis sativa and Cannabidiol: A Therapeutic Strategy for the Treatment of Neurodegenerative Diseases? STAT3 NGF APC GSK3B TRPV1 PMC9710321__F2 Cannabis sativa and Cannabidiol: A Therapeutic Strategy for the Treatment of Neurodegenerative Diseases? APC GSK3B TRPV1 PMC6398583__F3 Control of aerobic glycolysis by ERK and JNK signaling pathways in proliferating cells HEL-S-133P PARP14 BRAF HIF1A MYC PMC6398583__F4 ERK- and JNK-mediated phosphorylation of PKM2 is at the crossroad between proliferation and apoptosis EGF PARP14 PIN1 PMC4985055__F2 BMP signaling in bone SMAD1 MAP3K7IP1 SMURF1 DKFZp781O1323 GREM1 SMAD6 SMAD4 RUNX2 PMC4985055__F1 TGFB signaling in bone MAP3K7IP1 SMAD2 SMAD4 SMURF2 PMC7061838__F5 Relationships between GRHL2 and TGFB/MAPK signal pathways TF SMAD2 SMAD4 PMC6618030__F5 A suggested relationship between the defatting cocktail and intracellular lipolytic metabolic pathways ACOX1 FAS HEL-S-5 APOB PMC8591115__F7 KRAS mutation: from undruggable to druggable in cancer HRAS MTOR KRAS IRS1 PMC8861005__F7 Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway TG PCNA BCL2 IRS1 PMC8591115__F2 KRAS mutation: from undruggable to druggable in cancer CDC42 TBK1 EGF BAD TIAM1 MTOR KRAS PMC7664983__F1 Action of Statins and Potential Interactions with Estrogen CYP2C9 CYP3A4 PMC11211395__F3 Dual role of sirtuins in cancer: biological functions and implications XPA BAX ATR WRN SIRT1 PARP1 TDG SIRT6 PMC6874216__F1 The biosynthetic pathway of ubiquinone (Q) in E COQ7 IPP COQ3 COQ2 COQ6 COQ5 PMC4899530__F14 Mechanism of Nrf2 activation by DMF and MMF and its role in neuroprotection BACH1 KEAP1 MAF PMC11211395__F2 Dual role of sirtuins in cancer: biological functions and implications RPS15A SIRT3 TFRC SIRT4 MYC SIRT6 PMC3481038__F2 Scheme demonstrating mechanisms used by natural compounds to drive changes in the epigenome PCNA PTEN PMC7224341__F1 Compartmentalization of adenosine biochemistry PNP AK1 ADA PMC3225948__F7 Three arms of the unfolded protein response stress-responsive signaling pathway ELF2 ATF4 XBP1 PMC2797439__F1 Class IA PI3K signalling pathway RHEB TSC2 TSC1 PI3 FLCN PTEN MTOR FNIP1 PMC4964535__F1 Mechanism and pathway map of the prostate cancer (modified based on KEGG database) CD44 BAD HGF FRK SOX2 CDK2 BCL2 EZH2 PTEN MDM2 PMC6138501__F1 Inflammasome activation and purinergic signaling in Chlamydia-infected cells TLR4 IL1B PMC9144571__F2 Whole Aspect of Runx2 Functions in Skeletal Development BGLAP COL1A1 COL1A2 PTHLH SP7 IBSP TNFSF11 DLX5 RUNX2 SPP1 PMC9406852__F1 Transcriptome Profiling Reveals Differential Expression of Circadian Behavior Genes in Peripheral Blood of Monozygotic Twins Discordant for Parkinson’s Disease NR1D1 GPR157 PMC11598538__F3 Metabolites and DEGs in the biosynthesis pathways of fatty acid derivative and terpenoid in Oncidium Twinkle ‘Red Fantasy’ IPP LOX MVP MVK PMC2826542__F1 An Overview of IL-7 Biology and Its Use in Immunotherapy BAX GSK3B PTEN JAK1 PMC2738133__F3 Molecular Aspects of Moraxella catarrhalis Pathogenesis CEACAM1 HEL-S-62p VTN C4B_2 RAC1 PMC5932236__F4 Pan-cancer molecular classes transcending tumor lineage across 32 cancer types, multiple data platforms, and over 10,000 cases C6 CD80 CCL18 CSF1 PDCD1 DTX1 KEAP1 IDH3B FACL4 HIF1A CCL2 SUCLA2 SNAI1 HEL-S-5 PC HEL-S-32 MDH2 CPT2 NNT HES1 LAG3 NOTCH1 ACSL6 ACSL5 C7 HES2 TNFRSF4 TNFRSF9 APC PPM2C CTLA4 PDPR VEGFA NOTCH2 SAGE1 CTAG1B SDHD PDP2 TNFSF14 SDHB ACSL1 PDHA1 OGDH SUCLG2 PDC AXIN1 DLD PDHA2 SDHC XLKD1 ACLY HEL113 HEY2 HEL-S-62p PDK2 CS CTNNB1 SUCLG1 JAG2 NOTCH3 DLL3 CD48 CD244 IL10 FH ACO2 PDGFA DLL4 FASN ME1 PDK3 MMP9 DLAT PDK4 NFE2L2 ACADL BTLA CPT1A FGF18 CD68 MAGEA4 LCK PMC6367587__F9 Schematic map describing apoptosis induction of the TRAIL and Andro combination therapy BAX FADD PMC3693544__F1 Transcriptional feedback in the insulin signalling pathway modulates ageing RPS6 SHC1 SGK1 MED1 PMC3693544__F2 Transcriptional feedback in the insulin signalling pathway modulates ageing RHEB LPA PGC EEF2K RICTOR TSC1 C2 SIK2 PTEN CTNNB1 PMC8645722__F8 G protein pathway suppressor 2 suppresses gastric cancer by destabilizing epidermal growth factor receptor EGF CBL EGFR MTOR GPS2 PMC5390339__F1 Canonical Wnt signaling pathway APC LRP5 LRP6 CTNNB1 PMC4850838__F2 Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease LPL APOC3 ANGPTL4 PMC9697024__F8 Apigenin Ameliorates Hyperuricemia and Renal Injury through Regulation of Uric Acid Metabolism and JAK2/STAT3 Signaling Pathway STAT3 SOCS3 PMC7440669__F2 In silico co-factor balance estimation using constraint-based modelling informs metabolic engineering in Escherichia coli ME2 LDHD ME1 PMC3102743__F7 Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin SOX17 FOXH1 NODAL PMC3674720__F1 The insulin-signaling pathway CRK BAD FYN MTOR TRIB3 IRS1 PMC8085803__F2 Immunoceptive inference: why are psychiatric disorders and immune responses intertwined? IFNG CRH TNF PMC4931134__F1 Disruption of miRNA biogenesis by estrogens and cigarette smoke can lead to oncogenesis EGFR MYC DROSHA PMC11012149__F2 Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease HNRNPAB HMGB1 FAS CAD TRADD MLKL AIP MARCKS AIM2 IGF1R NLRC4 NLRP1 NLRP3 TLR4 HTT FADD PMC3891052__F3 Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns to Shape the Cancer Genome MAX BCOR ATR FAS RNF4 EGFR BRAF PTEN MTOR MYC TGFBR1 TRRAP GNAS HLA-DRA SPOP CCNE1 NF1 SHH NRAS SMO MDM2 NF2 SRC SMC4 RPL22 BAX SIK1 APC PTPN1 PTPRK ARHA TNF KRAS GATA3 VHL HRAS BRDT CHD4 PRKCI RUNX1 FOXO1 SUFU EP300 PSPH TRAF2 FADD TNLG7C PMC6929403__F2 The ceRNA networks involved in the chemokine signaling pathway CXCL9 CCL11 PPBP GNG13 CX3CL1 CXCL2 CXCL10 GNG11 CXCL3 PF4 PMC4969098__F3 Actions of IL-21 on T cells are context-dependent and shaped by cellular and environmental parameters STAT3 STAT1 STAT4 IRF4 MTOR PMC9021453__F6 Regularity of Toll-Like Receptors in Bovine Mammary Epithelial Cells Induced by Mycoplasma bovis IRF3 IRF7 MYD88 PMC5019180__F2 Complement-mediated regulation of metabolism and basic cellular processes MASP2 HEL-S-62p C1S CTSL BCL2 CD46 MTOR C4B_2 PMC2651433__F2 A nuclear SIRT1 mechanism for delaying NAD-ATP depletion through inhibition of PARP-1 is presented NMNAT1 NAMPT SIRT1 PMC7600363__F2 Biosynthesis and major signalling pathways activated by FLT3 wildtype (WT) (a) and FLT3 with internal tandem duplication (ITD) mutation (b) FLT3 NOX4 PMC6357151__F5 Differential Transcriptome Responses to Aflatoxin B1 in the Cecal Tonsil of Susceptible and Resistant Turkeys GRPR VIP GAL CCK PYY NMB SSTR5 GIP SST NPY2R CCKAR CHRM2 GIPR PMC2651433__F4 The Importance of NAD in Multiple Sclerosis PARP10 PARP6 SIRT7 PARP4 PARP16 PARG PARP14 PARP15 PARP8 SIRT4 SIRT5 SIRT2 PARP1 SIRT3 IFNG PARP12 PARP11 TRPM2 PARP3 PARP2 SIRT1 SIRT6 PMC6518944__F3 Metabolic dysregulation in GC‐derived B‐cell lymphoma SIRT3 IKZF1 PAX5 HIF1A MTOR MYC PMC6518944__F4 Aberrant BCR signaling in GC‐derived B‐cell lymphomas CD79B SYK CD79A TNFAIP3 HEL-S-62p CARD11 TLR9 IRAK1 PTEN MTOR TRAF6 IRAK4 IKBKG MYD88 BTK BCL10 BCR NFKBIE BLNK CD19 ID3 HVCN1 TCF3 IKBKB NFKBIA PMC6797793__F1 A schematic of the tanshinone biosynthetic pathway IPP CP PMC8556920__F1 Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment IGF1 HIF1A IGF1R MTOR PMC5945668__F3 Contraction of smooth muscle cell: cellular pathway and the role of MYL9 and of other genes related to MMIHS RHO PMC7831272__F7 Proposed model on the epigenetic regulation mechanisms of histone H3K27 acetylation causing the FLHS in laying hens TF FGF7 ANGPTL4 FABP1 KIT PMC3328452__F8 Identification of Protein Networks Involved in the Disease Course of Experimental Autoimmune Encephalomyelitis, an Animal Model of Multiple Sclerosis NAPA TUBA1A NAPB HEL-S-269 TUBB NEFH PGAM1 C10orf27 ACTR3 APP HEL-S-66 ENO1 KCNMA1 PS1TP5BP1 PMC3671248__F7 Model for 20E regulation of IMD innate immune signalling DPT FADD PMC9002353__F7 mTOR Signaling Pathway Regulates the Release of Proinflammatory Molecule CCL5 Implicated in the Pathogenesis of Autism Spectrum Disorder GSK3B CREBBP CCL5 MTOR PMC4529006__F1 Genes within the BDNF signaling pathway [adapted with permission from Macmillan Publishers Ltd FRS2 PDPK1 CAMK4 GRB2 BDNF SYN1 PMC10875059__F1 Metabolic pathway of risperidone UGT1A1 CYP3A4 ABCB1 PMC5653411__F1 Apoptosis and necroptosis as host defense strategies to prevent viral infection RIPK3 BAX CGAS MAVS TRADD TLR3 MLKL RIPK1 IRF3 FADD PMC8927965__F2 Dysregulation of Survivin-Targeting microRNAs in Autoimmune Diseases: New Perspectives for Novel Therapies STAT3 TGFB1 SFMBT1 E2F3 PI3 SMAD2 PTEN PMC10875059__F3 Pharmacogenomics and non-genetic factors affecting drug response in autism spectrum disorder in Thai and other populations: current evidence and future implications CYP3A4 ABCB1 PMC6696086__F5 Signaling pathway regulating pluripotency of stem cells is modified during neural differentiation KLF4 MAPK13 BMP2 FZD9 WNT4 APC2 PMC6363687__F4 FGFR1 pathway promotes NFKB signaling MAP3K7IP1 TRADD TAB3 FGFR1 PMC2395193__F3 Gene networks identified in both recEbo-VP35/WT- and recEbo-VP35/R312A-infected cells compared to mock-infected and irradiated controls RASSF1 SLC19A2 TANK PCBP1 FOS KITLG CDKN2A SUPT16H HEL-S-68p ENO1 RPL9 CTNNA1 EMB NARF TM4SF1 PMC6412296__F1 Intrinsic and extrinsic apoptotic signalling pathways and points of therapeutic intervention BAX MCL1 FADD PMC11476647__F1 Nrf2/Keap1/ARE signaling pathway REST BRF2 KEAP1 PMC3775564__F5 Molecular network analysis of the miR-200 family and potential molecular targets with Ingenuity pathway analysis (IPA) BMI1 TFRC TFR2 HNRPA3 E2F4 CTBP1 AGTR1 HFE B2M ZEB2 PMC3089921__F1 mTOR activation supports cancer cell survival LAT MTOR CCND1 PMC6993271__F1 Actions of metformin in eukaryotic cells STAT3 ATF3 MTOR PMC11476647__F2 Pathways influencing Nrf2 build-up and its downstream pathways KEAP1 PGAM5 GC PTEN PMC7026856__F1 [U-13C6]-glucose metabolism in the brain MAL GIP CIT PMC7581685__F2 Part of the innate immune signaling pathways triggered after the viral RNA is recognized by TLRs and RLRs TBK1 MAVS STAT2 TANK IRF3 IRF7 TRAF3 MYD88 STAT1 TLR3 IFNAR2 IFNAR1 TLR8 TLR7 JAK1 TYK2 PMC9684661__F2 Immunometabolism in the pathogenesis of vitiligo CXCL9 CXCR3 STAT1 CXCL10 PMC5137695__F5 Summary model of Tri-DAP activity and pathway utilization in HCMV-infected cells TBK1 RIPK2 IRF3 NOD1 PMC9684661__F1 Immunometabolism in the pathogenesis of vitiligo CXCL9 PDC CXCL16 CXCL10 PMC4013640__F2 Pericyte physical and biochemical interactions at the NVU CDH2 TGFBR2 PMC7279287__F1 Synthesis of butyrate in E FAS HBD PMC2845642__F2 Molecular Mechanisms of T cell Receptor and Costimulatory Molecule Ligation/Blockade in Autoimmune Disease Therapy LAT LCK PMC3672773__F1 Schematic presentation of select miRNAs that regulate toll-like receptor signaling pathways TBK1 MAL TLR9 TLR5 IRF3 IRAK2 IRF7 IL6 TRAF3 TRAF6 MYD88 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC1698636__F6 F igure 6.— HMFT1766 CDC34 PMC151039__F1 The classical pathway for bile acid synthesis begins with CYP7A1, which converts cholesterol into 7Alpha-hydroxycholesterol CYP7A1 CYP7B1 PMC3863339__F1 RACK1 signaling complexes BAX SRC CCND1 PMC3286973__F2 Cell-line subtypes have unique SuperPathway network features MAX VTN MAPK9 MYC SKP2 RUNX2 XBP1 PISD CTNNB1 FOXM1 TFF1 CCND2 E2F3 SHH CAMK4 EIF4A1 HEL-S-44 CDK4 ZFP36 MSH2 KLK3 VCAN GCG POLR3D APOB BCAT1 FOXA2 MAP2K1 PMC3286973__F3 Pathway diagrams can be used to predict response to therapies FAS ERBB4 ERBB3 EREG CASP6 PLK3 CHEK2 CHEK1 TP63 ERBB2 ATM GADD45A BCL6 PMC11064802__F7 Action of carbohydrates in atherosclerosis therapy NR1C1 ABCG8 ABCG5 NPC1L1 MTOR MYD88 PMC11064802__F1 Action of TCM prescriptions and natural bioactive molecules in atherosclerosis therapy by targeting peroxisome proliferator-activated receptors (PPARs) ACOX1 ABCG1 NR1C1 CD36 TLR4 ABCA1 CPT1A MYD88 PMC4831128__F6 Ingenuity Pathway Analysis (IPA) of cholesterol and bile acid metabolism genes PPARG ABCG1 NR1C1 NR1H3 NPC1 RXRA APOE ABCA1 PMC3186046__F1 S1P receptor subtype-specific heterotrimeric G protein coupling and intracellular signaling mechanisms S1PR1 S1PR3 S1PR2 PTEN RHO PMC9519310__F7 Interaction of the IFNG/JAK/STAT1 and JAK/STAT3 Signalling Pathways in EGFR-Mutated Lung Adenocarcinoma Cells STAT3 STAT1 EGF EGFR PMC2654418__F6 Crosstalk between the Androgen Receptor and Beta-Catenin in Castrate Resistant Prostate Cancer TCF3 YES1 CTNNBIP1 GSK3B TCF4 LYN MYC LEF1 CTNNB1 PMC8520212__F5 The tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor? TIGIT CEACAM1 SIRPA HP CD47 PMC2663816__F1 Single-Cell Profiling Reveals the Origin of Phenotypic Variability in Adipogenesis tmp_locus_29 RS1 HEL-S-11 PMC12150179__F2 Influence of ROS induced by microplastics on macrophage metabolism, function, and polarization CD40 NOS2 CGAS CD36 GPX4 MTOR CCL2 RIPK3 TFRC GSDMD NLRP3 COX2 ATM CD163 PMC12150179__F3 Microplastics indirectly affect macrophages by disrupting gut microbiota COX2 TLR4 CCL2 PMC8470673__F1 High-Fat Diets Modify the Proteolytic Activities of Dipeptidyl-Peptidase IV and the Regulatory Enzymes of the Renin–Angiotensin System in Cardiovascular Tissues of Adult Wistar Rats HYI ACE2 ADA PMC5104457__F1 ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis RIPK3 MLKL RIPK1 CPD PMC5354977__F1 Interplay between immune checkpoint proteins and cellular metabolism CD80 HEL-S-133P HIF1A CTLA4 MTOR PMC5292326__F1 Functions of natural IgM in homeostasis maintenance and autoimmune diseases prevention; (A) sIgM enhances apoptotic cell clearance BCR CD5 PREB PMC8615588__F1 Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs EGF TGFA ECD ERBB4 EGFR NRG3 ARHA NRG4 ERBB3 NRG2 NRG1 ERBB2 GRB2 PMC6753603__F2 Schematic overview of the two most common pathways with genetic alterations in thyroid cancer—mitogen-activated protein kinase (MAPK) and phosphatidylinositide 3-kinase (PI3K) pathways TSC2 TSC1 ALK NF1 FGFR1 FGFR3 PTEN MTOR RET FGFR2 PMC8256363__F9 Novel lncRNA promotes myogenesis of bovine skeletal muscle satellite cells via PFN1‐RhoA/Rac1 PFN1 ARHA RAC1 CTNNB1 PMC5293166__F4 Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy IFNG BACH2 SELL FOXO1 C2 CCR7 PTEN FOXP3 PMC9465037__F2 Bacterial cyclic di-adenosine monophosphate in the host immune response NLRP3 DDX41 IRF3 PMC10706706__F6 DEGs expression pattern diagram of JA biosynthetic pathway in mustard leaves after beet armyworm larvae chewing LOX AOC2 PMC6450927__F10 Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A NLRP3 TXNIP TLR4 MYD88 PMC6407289__F11 Model for Pyk2 action in AD risk FYN ROCK2 PSD ABO ARHA PMC9520111__F2 TNFIFN-induced necroptosis RIPK3 ZBP1 TRADD MLKL IFNAR1 CASP3 TNF TRAF2 FADD PMC7555743__F7 Schematic diagram showing the signaling pathways involved in anti-inflammatory effects of the combination of ginsenosides Rg2 and Rh1 in macrophages STAT1 TLR4 IL1B PMC8882979__F1 Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs ROR1 APC ROR2 LRP5 LRP6 PMC5470107__F2 Interconnected processes of (i) S1P synthesis and degradation within the sphingomyelin/salvage pathway, (ii) S1P export and (iii) signaling through binding to five specific G-protein-coupled receptors, S1PR1-5 S1PR1 SPP2 SPNS2 S1PR3 SPHK2 S1PR2 SPHK1 RHO S1PR5 SPP1 S1PR4 PMC5638182__F2 Mongersen, tofacitinib, filgotinib: mechanisms of action SMAD2 JAK3 PMC6265005__F1 Tumor necrosis factorA pathway for necroptosis RIPK3 TRADD MLKL RIPK1 TNF TRAF2 FADD PMC8127406__F7 Multi-OMICS study of a CHCHD10 variant causing ALS demonstrates metabolic rewiring and activation of endoplasmic reticulum and mitochondrial unfolded protein responses HTRA2 CHCHD2 CHCHD10 FGF21 GDF15 CLPP MTOR XBP1 PMC8296533__F1 Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment PDPN CXCL12 CCL28 CSF1 PDGFC FGF2 PMC4677515__F1 Survey of the Impact of Deyolking on Biological Processes Covered by Shotgun Proteomic Analyses of Zebrafish Embryos GNGT1 GDF8 TGFBI CLEC7A MEF2B ATP6V1A SNAP91 ATP2A1 CYTIP POSTN HSPD1 MAP2K6 USP1 HSPA2 HP1BP3 NRAS CCDC14 KRT7 MDH2 AHNAK CCL1 CCR1 HNRNPL PYGM AMPD1 GDI2 HEL-S-278 HSD17B10 KRT4 HEL-117 ME3 UQCRC1 MKS1 CCL24 HEL-S-66p SETD3 CRISP3 CASQ1 FPR1 CRYBA2 HEL-S-57 IL8RB ADAP2 NTHL1 GNG7 AVP CNNM2 CRYBB1 SPAG1 NOL11 TRH CCL22 DCHS1 GNB1 SUMO1 NME2 YWHAQ SNAPIN AK1 TTN LAMTOR1 ADCY6 CLTC RRAGA CCL17 HMGB1 UBC ACO2 RPS5 PKP1 EEF1G NPHP1 CXCL6 INVS INPPL1 HEL-S-87p RASD2 SLC38A9 PMC2629585__F7 Local Inflammation Induces Complement Crosstalk Which Amplifies the Antimicrobial Response CRP HEL-S-62p C2 C1S C1R PMC6355880__F8 Model describing the distinct fates of NK cells during NK cell education PI3 HEL-S-11 PIKFYVE PMC7564754__F4 How selected polyphenols can interact with p57 expression and activity (see and text for details) EGR1 PCNA CDKN1C PMC7278812__F3 Selenium-dependent antioxidant system of glutathione peroxidases (GPx) and thioredoxin reductases (TrxR) GPX4 GPX1 PMC8101358__F1 Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome PTPN22 SPTLC2 SPTLC3 SGPP1 DEGS1 ABHD4 SPTLC1 FAAH SGPP2 GDE1 PMC7564754__F3 Selected polyphenols that interfere with p27 expression and activity (see and text for details) CDKN1B CDK2 SRC PMC4940708__F8 Mechanism of the disease-modifying effect of P021 in AD GSK3B APP BDNF PMC6010716__F3 Genes predicted to increase cardiovascular angiogenesis are strongly up‐regulated by CpG pre‐conditioning 24 h post‐I/R CEACAM1 ITGAM ITCH SET PMC8204760__F3 Non-G-protein signaling at 5-HT receptors CDC42 CDK5 APP SRC PMC8204760__F4 Constitutive activation of 5-HT6 receptors by different GPCR-interacting proteins (GIPs) CDC42 CDK5 NF1 GIP MTOR PMC9425441__F7 Vascular Endothelium and Coagulation: Homeostasis, Disease, and Treatment, with a Focus on the Von Willebrand Factor and Factors VIII and V VWF PC ADAMTS13 PMC4085546__F2 KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma SMO MMP9 VEGFA KRAS PMC8473645__F8 Glutathione peroxidase 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis GSTM1 NR2F2 GPX4 PMC6747935__F2 How insulin-stimulated cleavage of TUG and subsequent trafficking of GSVs coordinately regulates multiple physiologic effects USP25 HEL-S-61 IRS1 PMC6370335__F2 Intercellular and intracellular signals that initiate liver regeneration STAT3 EGF HBEGF HGF TGFA IL1B PMC12026336__F1 RSV infection induces TLR signaling TLR4 CD14 TRAF6 PMC4256331__F11 The signaling pathways affected by Syk that drive AB production, neuroinflammation, and Tau hyperphosphorylation SYK BACE1 GSK3B PMC7988780__F3 Is nuclear sirtuin SIRT6 a master regulator of immune function? GLS MYC SIRT6 PMC3876437__F1 A non-canonical JAK-STAT pathway in IFN therapy of poxvirus infection and multiple sclerosis IFNGR2 IFNGR1 JAK1 PMC5000752__F7 Simplified representation of canonical and non-canonical Hedgehog(HH) signaling HHIP SUFU PTCH1 SMAD4 SMO MTOR GLI3 PMC3000843__F1 Schematic representation of chiral 3HV production via the threonine biosynthesis pathway in metabolically engineered E HBD THRA PMC10520719__F11 ADAM11 a novel regulator of Wnt and BMP4 signaling in neural crest and cancer HSP90AB1 SMAD1 ADAM11 DKFZp781O1323 BMP4 SOX2 SOX3 FZD7 LRP5 LRP6 CCND1 CTNNB1 PMC5000752__F6 Androgen receptor (AR) signaling pathway GRB2 SRC PMC9682156__F1 Autophagy and the primary cilium in cell metabolism: What’s upstream? SMAD2 MC4R FLCN MTOR PMC2491599__F2 Wnt canonical signaling pathway MMP7 JUN APC CER1 MYC WIF1 PMC3415084__F2 Impact of placental insufficiency on endocrine responsiveness in fetal myoblasts and myofibers IRS1 PMC8307885__F2 Nano-Strategies Targeting the Integrin AvB3 Network for Cancer Therapy CASP2 CBY1 CEACAM6 SRC CTNNB1 PMC2491599__F3 Wnt signaling pathwhay in cervical cancer FZD3 ROCK2 APC NLK PMC5546324__F5A AKT/PKB Signaling: Navigating the Network RHEB TSC2 COIL TBC1D7 PMC8995861__F3 Oxidative RNA Damage in the Pathogenesis and Treatment of Type 2 Diabetes NUDT15 NUDT18 NUDT5 PMC9307784__F4 Orbital fibroblasts (OFs) in acute and chronic TED CD40 TSHR IGF1R PMC8970309__F2 Overcome Drug Resistance in Cholangiocarcinoma: New Insight Into Mechanisms and Refining the Preclinical Experiment Models APC ABCG2 PMC3133937__F1 Concerted regulation of the WNT-DVL-GSK3B signaling pathway in NAc by chronic social defeat stress PROP1 AXIN1 WNT4 AXIN2 CTNNB1 PMC8850271__F1 Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease CYP7A1 GCA CYP27A1 PMC8850271__F2 Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease FGF8A CYP7A1 FGFR4 PMC4493455__F2 Schematic overview of ligand-stimulated SR signal transduction FYN CD36 LYN SRA1 PMC8861487__F2 Innate Immunity in Natural Elite Controllers of HIV-1 Infection CGAS TLR3 TLR4 TLR9 TLR8 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC11915864__F9 RNF20 demonstrates dual regulation of the chicken MDA5-IFNB signaling pathway by targeting chMDA5 (created using Figdraw) TBK1 MAVS RNF20 IRF7 PMC3986510__F1 Ceramide de novo synthesis pathway CERS3 CERS5 CERS1 CERS2 CERS6 PMC3986510__F4 Diagram demonstrating sites of interference by various small molecule agents or genetic ablation of enzymes engaged in ceramide and sphingolipid synthesis pathway CERS3 CERS5 CERS1 CERS2 CERS6 PMC6194161__F1 TLR and CLR interactions with helminth-derived products HEL-S-92n SYK NLRP3 TLR3 TLR4 MYD88 PMC8508851__F13 Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey ATM PTEN MDM2 PMC3613056__F7 Pathway scheme of baicalein on the cell proliferation inhibition and cell metastasis inhibition in human bladder cancer cell 5637 GSK3B MMP2 MMP9 CCNB1 CCND1 PMC3688269__F2 Dysfunctional telomeres activate upstream checkpoint PI3 kinases, such as ATM (ataxia-telangiectasia mutated) or ATR (ataxia-telangiectasia and Rad3 related), - () ATR CDK6 ATM CDK4 PMC3513735__F3 Most enriched molecular networks showing interactions between the significant genes (according to SAM)—(a) FOSB, ERK, MAPK3, CYR61, and the RAS-genes; (b) DUSP1, ERK1/2, P38MAPK, DUSP9, and RASD1; (c) CYR61 and NFRKB ZFP36 PACSIN2 VEGFC FOSB C21orf58 NFRKB dik ARHGEF5 DUSP9 TSC22D3 SHE NCK2 RHOV SSBP2 SLC25A4 RHOU GRB7 BCR EDC4 SP100 OSMR RHOB TRAM2 PMC5421758__F2 Identification of potential new treatment response markers and therapeutic targets using a Gaussian process-based method in lapatinib insensitive breast cancer models OGA GABARAP WNK1 OGT CD46 RNP24 EFS STUB1 GNAS STAT1 TRIM28 PKNOX1 WDR37 CLTA NDUFB4 PECR NOTCH1 HTT MAPK1 NR1i1 MLPH TBCB POLM FRS2 RNF10 PITPNB TWF1 BARD1 NONO SAFB USP22 EGF MMP14 VAMP2 SBF1 CDYL MTSS1 PPP2CA TNS1 ATXN2L RHO SLTM DST ZNF710 GDPD2 KLHDC2 PIGO MPL MAEA PRKCSH BTRC U2AF2 MED16 AIMP2 NFKBIE FOXA1 SNRPG PTN COPZ2 XPO7 STS NPPA ELAVL1 PAPOLA NUP153 EP300 MAP2K1 LYN PFKL HNRNPC XPOT YWHAZ PMC2711321__F2 Wiring diagrams for a three-module decomposition of the intrinsic apoptotic pathway BAX HEL-S-62p C9 BCL2 PMC11240800__F2 Abnormal signaling pathways contribute to the pathogenesis of uLMS SUFU SMO GRB2 SRC PMC7564554__F7 lncRNA–mRNA co–expression network INAFM2 PMC6430781__F5 Sub-network of the innate signaling pathway obtained after IPA analysis of the differentially expressed genes in A549 lung epithelial cells infected with WM 06.482 conidia ZFP36 MAFK MAFF BCR JUNB RELB CS PIGS PMC4433221__F5 Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode BAX STAT2 PSMB8 IRF9 PIAS1 IRF1 IFI35 JAK1 PMC2267714__F3 Gene expression changes detected in selected pathways in M group ATR PCNA CDR2 PMC4433221__F6 Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode EPCAM ADAR UBA7 STAT2 BPI IRF9 IRF3 MX1 RSAD2 OAS2 ENPP1 PMC9298548__F3 Comparative Transcriptome Analysis Reveals the Mechanism Associated With Dynamic Changes in Meat Quality of the Longissimus Thoracis Muscle in Tibetan Sheep at Different Growth Stages RHEB TSC2 FAS INSR CD36 F2 CFTR PDK2 MTOR INS SIRT1 PMC6612360__F1 Endothelial dysfunction and angiogenesis impairment in the ageing vasculature PARP11 IGF1 MTOR SIRT1 PMC7651862__F8 Our working model in this study CD44 MMP7 TRIM37 GSK3B PTEN TCF4 CCND1 LEF1 TWIST1 CTNNB1 PMC5819357__F1 Combinatorial CRISPR-Cas9 metabolic screens reveal critical redox control points dependent on the KEAP1-NRF2 regulatory axis HEL107 ENO2 HK3 PC HEL-S-32 MDH2 GCK PFKM PKLR GOT2 H6PD HEL-S-133P HK2 HEL-S-278 MAL LDHB ME1 RPE PDHX PGAM1 DLAT PDHA1 PGAM2 ALDOB ENO3 RPIA FBP2 ME2 HEL-S-68p PFKP HEL-S-162eP HEL-S-49 DLD ENO1 PDHA2 PFKL HEL-S-87p PMC8804062__F1 Neurobiological Opportunities in Diabetic Polyneuropathy RB1 BAX BAD CDK6 SEMA3A PTEN ARHA MTOR CDK4 PMC5852779__F2 TLR2, TLR4, and TLR5 signaling pathways TBK1 TLR3 TLR4 IRAK1 TLR5 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC6326689__F3 Molecular pathways modulating lifespan via control of the translation machinery RHEB RPS6 EEF2K TSC2 EIF4B TSC1 LARP1 ELF2 EEF2 ATF4 EIF4E PMC8874935__F3 Vav Proteins in Development of the Brain: A Potential Relationship to the Pathogenesis of Congenital Zika Syndrome? CDC42 SOCS1 ZAP70 RHO USP9X RAC1 PMC3334407__F5 Schematic model for inhibition of cell proliferation by EGCG analogs TSC2 TSC1 MTOR PMC6594015__F6 Schematic depiction IRF6 PDK2 MTOR PMC4915230__F1 Cell signaling pathway through which DD complex elicits a balance between survival and programmed cell death RIPK3 TRADD TAB3 RIPK1 TNF CYLD TRAF2 FADD PMC12223915__F6 Serum Pharmacology Combined with Network Pharmacology Reveals the Effects and Mechanisms of Ganmai Dazao Decoction in the Treatment of Depression OXT VIP RAI1 NPY SHE PMC4051765__F1 Responses of the Insulin Signaling Pathways in the Brown Adipose Tissue of Rats following Cold Exposure CRK TSC2 BAD CBL GRB10 VAMP2 PTEN SOCS3 GRB2 MTOR EIF4E PMC9559204__F8 Mycobacterial acyl carrier protein suppresses TFEB activation and upregulates miR-155 to inhibit host defense TFEB MTOR PMC7700034__F7 Schematic outline representing the acute effect of AB (1-42) on cholesterol dyshomeostasis-induced neurotoxicity and its possible protection through quinovic acid BAX GFAP HMGCR KEAP1 SYP BACE1 CASP3 IL1B PMC7830632__F1 Apoptosis, inflammation and endoplasmic reticulum (ER) stress regulated by the caspase family BAX TMEM214 FAS AIM2 PMC3658451__F2 Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity TLR1 BCL10 TLR3 TLR4 TLR9 TLR8 NOD2 TLR5 TLR7 CARD9 PMC7830632__F2 Response model of Ras/phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR pathway to the growth factors, amino acids and glucose levels RHEB ECHS1 RICTOR SH3BP4 PTEN MTOR IRS1 EIF4E PMC7723170__F1 Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC5021946__F4 Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways AGXT2 GLDC HEL-S-182mP AGXT DGKA CTH FLJ10842 SRR MGLL PMC6429193__F1 JAK2-STAT5-SOCS pathway and domain structure of STAT5 OGA CDK8 OGT PAK1 COIL EPO RHO MTOR SRC PMC4808242__F1 Obesity-linked metabolic pathways susceptible to diet induced epigenetic perturbation ST8SIA4 TH PPARG CEBPA NNMT LEP SLC6A3 FASN POMC CDKN1C SETDB1 MBD2 PMC7764689__F3 Ingenuity pathway analysis (IPA) network analysis of the modified proteins in response to BK 48 h stimulation relative to control in RASMC RPS6 CAV2 TNC HEL113 HEL-S-130P PXN HEL-S-102 PMC3745259__F1 The hexosamine biosynthetic pathway provides the donor substrate for O-GlcNAcylation and other types of protein glycosylation OGT PGM3 PMC316921__F6 Wnt signaling in the early C. elegans embryo APC POP1 PMC3745259__F2 O-GlcNAc is involved in the cellular stress response OGT MAP3K7IP1 SP1 HSF1 GSK3B GPX1 PMC4369723__F5 Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B STAT3 STAT1 EGF TGFA SP1 EGFR GRB2 PMC8304542__F2 Anti-VEGF(R) Drug Discovery Legacy: Improving Attrition Rates by Breaking the Vicious Cycle of Angiogenesis in Cancer VEGFB VEGFC PIGF VEGFD VEGFA PMC11394487__F5 AMPK signaling pathway RPTOR STK11 EIF4EBP1 STIM1 ULK1 FASN MTOR STRADA MLST8 TSC2 EEF2K TSC1 NR2A1 HMGCR EEF2 CFTR CPT2 CCND1 PMC8873123__F3 Autophagy plays a double-edged sword role in liver diseases HMGB1 TGFBI ATG12 ATG9A MTOR ATG5 PMC8288800__F5 Long noncoding RNAs in metastasis site-specific tropism STAT3 NSUN6 CCL2 PMC11394487__F6 ERK/MAPK signaling pathway PPARG BAD SHC1 PXN EIF4EBP1 LAMTOR3 CRKL KSR1 BRAF RPS6KA1 NFATC1 PTK2B DUSP2 FOS DOCK1 EIF4E ARAF CRK STAT1 MOS RAPGEF1 SRC PMC6070639__F2 PA induces the upregulation of PGC-1A expression via multiple signaling pathways TFAM PGC IGF1 MTOR NRF1 GPX1 PMC8288800__F3 Long noncoding RNAs regulate metastasis via various pathways using diverse mechanisms TCF7L2 ITGB4 GSK3B EZH2 FOXA2 ZEB2 MTOR MYC JARID2 CTNNB1 PMC4149521__F4 Gene Expression Profiling Reveals Epithelial Mesenchymal Transition (EMT) Genes Can Selectively Differentiate Eribulin Sensitive Breast Cancer Cells EGF HGF SP1 EGFR EDNRA ARHA NOTCH1 PS1TP5BP1 FGF2 PMC7578566__F3 Cellular senescence by extracellular matrix during chronic fibrotic diseases CYR61 EBP SMAD2 APC SMAD4 RAC1 CTNNB1 PMC11394487__F7 PI3K/AKT signaling pathway BAD RAF1 SHC1 MCL1 SFN PTEN MTOR CTNNB1 PDPK1 MAPK8IP1 MDM2 CCND1 HEL2 LIMS1 EIF4EBP1 HEL-S-28 EIF4E RHEB TSC2 TSC1 CDKN1A CDKN1B BCL2 MAP3K5 CDC37 GRB2 GAB2 PMC4763954__F1 Fas:FasL interactions FAS TRAF1 FADD PMC7432812__F2 Schema for the mechanisms for different types of cell deaths BAX BAD FAS TRADD GPX4 MLKL LPCAT3 DFNA5 RIPK3 GSDMD BMF HRK TRAF2 FADD PMC11394487__F2 Mitochondrial biogenesis pathways TF TFAM PPRC1 MAK PMC5295669__F2 Modes of DNA synthesis RAD52 PIF1 RAD51 PCNA POLK POLE PMC8288800__F6 Long noncoding RNAs and tumour microenvironment HNRNPL CCL2 PMC8490516__F8 Kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis ICOS TFRC FOXP3 PMC11953055__F8 Schematic illustration summarizing the mechanism by which NSUN2 promotes colorectal cancer (CRC) STAT3 NSUN2 EGFR CUL4B PMC4452855__F2 Types I and III IFNs canonical signaling pathways SOCS1 IFNLR1 STAT2 IFNA4 IRF3 IRF7 IFNA2 IFNAR2 USP18 IFNAR1 ISG15 IFNA1 TYK2 PMC9305279__F1 Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19 ATG12 ULK1 TFEB ACE2 PMC9305279__F2 Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19 TMEM41B VPS11 ATG12 ULK1 SNAP29 VMP1 VPS39 STX17 VAMP8 ACE2 PMC6895510__F1 Regenerative abilities contribute to the application of BM-MSC in psychocardiological disease VWF GFAP FOXC2 F2 FOXC1 NOTCH1 PMC9015857__F10 Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis MAPK1 SYK PLCG1 LAT GRB2 PMC6996643__F2 Meta‐analysis and field synopsis of genetic variants associated with the risk and severity of acute pancreatitis DEFB1 IL10 TNFAIP3 TIRAP TLR4 NFKBIA CD14 IRF3 LBP MYD88 PMC8534037__F2 Microenvironmental Reactive Oxygen Species in Colorectal Cancer: Involved Processes and Therapeutic Opportunities HGF SMAD2 GSK3B SMAD4 CTNNB1 PMC5752239__F9 The putative mechanism involved in the transdifferentiation from SESCs to CECs DOCK9 NEUROD1 DKK1 PAX6 CTNNB1 PMC11475022__F6 GSEA of 18 patients with CTEPH from the GEO database TH GUSB ABCC1 EBP SURF1 SMC3 FHL2 FADS2 ACADM POP1 MRPS15 MRPS30 ARHGEF12 PTS CYBA CPT2 CNTRL CENPF TNFRSF12A CRAT TRIO COL1A2 SMS SSH2 HEL-S-278 APC MAL STARD4 CEP250 HMGCS1 SDHA DLAT HEL-S-87p NIPBL PMC7736044__F1 Interplay between cysteine protease activation and mitochondrial deteriorating processes in MS myelin degeneration LAMP2 PMC3887753__F1 Sequential pathway leading to renal ischemia-reperfusion injury CCR5 IL8RB PMC2695499__F10 Changes in OSM signaling STAT3 OSM OSMR IL6ST JAK1 TYK2 PMC12199726__F1 Molecular and cellular signaling of intestinal tuft cells in response to infections IL25 PLCG2 TRPM5 SPIB ChAT PMC3532050__F1 NFKB inhibition by A20 in the TNFR1 signaling pathway TRADD ITCH RNF11 RELA TRAF5 TNF TRAF2 PMC3376977__F2 NK cells sense tumors, course of disease and treatments IFNG STAT1 BCR HLA-G VHL PMC8309156__F1 Behind the Adaptive and Resistance Mechanisms of Cancer Stem Cells to TRAIL BAX ABCG5 FADD PMC8419687__F2 IL‐4‐induced changes in metabolism and their effects on gene expression CD36 EIF5A ARG1 IRF4 PMC9082817__F7 Transcriptomic Profiles of Splenic CD19+ B Cells in Mice Chronically Infected With the Larval Echinococcus granulosus MMP14 F5 AGPAT4 CD46 GPX3 NFIL3 ITGAV MPL POSTN STAT1 IL1R1 COL1A1 MFGE8 SULT1A1 OSMR CD9 ALOX12 LILRA6 CDH2 IFITM2 COL1A2 IFITM1 CFH CD14 TGFBR3 CYP1B1 CD55 STEAP4 ITGA2B CD34 GM2A COL6A1 PDGFRA NRIP3 ENPP2 CD63 PF4 PMC514582__F10 Schematic of Nef signaling pathways and their relationship with Nef’s biologic effects in podocytes MAPK1 STAT3 SRC PMC11484033__F6 Lats-IN-1 protects cardiac function and promotes regeneration after myocardial infarction by targeting the hippo pathway LATS1 LATS2 PMC12153738__F4 PGRN’s multifaceted roles in lysosomal function, autophagy, and metabolism impacting cardiovascular health CD36 TFEB SOCS3 IL6 PMC3847559__F5 Combining DC vaccination with immune checkpoint blockade CD80 PMC12153738__F3 Progranulin (PGRN) in vascular pathophysiology SMAD1 SORT1 DKFZp781O1323 EPHA2 TLR4 VCAM1 PMC5784573__F2 Radiation effects on antitumor immune responses: current perspectives and challenges CD80 HMGB1 FAS CGAS C5AR1 HEL-S-62p C3AR1 TLR4 CXCL16 ATM VCAM1 CCL2 PMC5968744__F1 Schematic representation of the signal transduction pathway of ATF3 protecting against I/R-induced inflammation, apoptosis, or myocardial injury in various organs TF HDAC1 ATF3 PMC4982433__F3 Signalling pathway and targeted therapy in gastric cancer KMT2A KMT2C HGF RAF1 PTCH1 EZH2 SMO MTOR FGFR2 PMC7485092__F2 Innate and adaptive immune responses in SARS-CoV-2 Infection IFNG IL10 IF2B1 IL4 IL6 CCL2 CXCL3 PMC8670437__F7 In situ Metabolomics of Metabolic Reprogramming Involved in a Mouse Model of Type 2 Diabetic Kidney Disease FAS HDC pcap PMC2874622__F2 The Role Of Mitochondria In The Mammalian Antiviral Defense System NLRX1 MAVS MFN2 UQCRC2 PMC9140097__F1 Chromosomal Instability in Chronic Myeloid Leukemia: Mechanistic Insights and Effects BCR GC SSB PMC8002454__F1 Rheb-mTORC1 signaling pathway in neurodegeneration RHEB MLST8 TSC2 TSC1 ULK1 BACE1 TBC1D7 MTOR PMC2722250__F2 Silent chromatin assembly in budding and fission yeast CHP2 CHP1 ARC PMC8637215__F7 Cytokine and Complement Response in the Glaucomatous BB1-CTGF Mouse Model HEL-S-62p CFD CXCL1 CXCL2 CXCL10 PMC12024285__F12 1-DNJ alleviating OS in porcine GCs BAX PGC MFN2 MCU ATF4 PMC2707511__F6 DNA Topoisomerase I Inhibitors: Chemistry, Biology and Interfacial Inhibition ERCC1 TDP1 RAD50 MRE11A BRCA1 MDC1 EME1 PMC9524011__F2 Dysfunction and ceRNA network of the tumor suppressor miR-637 in cancer development and prognosis TF STAT3 EGF EGFR HEMGN LIF NUPR1 WNT1 PTEN CTNNB1 PMC3183400__F4 New Insights into insulin resistance in the diabetic heart STAT3 SOCS3 IRS1 PMC8231807__F1 FGFR Inhibitors in Oncology: Insight on the Management of Toxicities in Clinical Practice FGF8A CYP24A1 BRAF MTOR KRAS PMC5226550__F7 Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes CSK PTEN SRC PMC4779427__F6 DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States BMPR2 APOD BMPR1A NCF2 APOE HIF1A EGLN3 NCF1 CTNNB1 TCF7L2 OLR1 ISL1 MAP2K4 CDKN1A IGFBP5 MYPN ABCC9 HSPB8 PMC7310212__F1 Modeling the Tumor Microenvironment and Pathogenic Signaling in Bone Sarcoma LATS1 RHEB TSC2 TSC1 IGF1 PTEN IGF1R RHO MTOR EIF4E PMC4955846__F1 Toll-like Receptors, Triggering Receptor Expressed on Myeloid Cells Family Members and Receptor for Advanced Glycation End-products in Allergic Airway Inflammation STAT3 SYK IRAK1 GRB2 TRAF6 IRAK4 PMC6944218__F5 PCB153 exposure altered forkhead box O (FOXO) signaling pathway PRMT1 STAT3 EGF KLF2 EGFR SMAD4 BNIP3 IL7R RAG2 PTEN IGF1R PDK2 ATG12 INSR CDK2 ATM RAG1 NLK GRB2 PMC9086899__F4 BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications TF BMPR2 SMAD1 MAP3K7IP1 DKFZp781O1323 SMAD4 ATF2 PMC6479341__F1 The role of unfolded protein response (UPR) in cell survival upon induction of ER stress ATF4 EIF2A PMC2677752__F1 Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development ENG IL16 HOXA5 PMC6050934__F7 NOX4/TRPC6 pathway is important in podocyte calcium regulation and renal damage progression in diabetic kidney disease ROS1 TRPC6 NOX4 PMC11015223__F9 OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS–STING pathway to mediate GBM immune escape BNIP3 OMA1 BNIP3L PMC4223653__F2 Neurology of mTOR RHEB EGF TSC2 TSC1 IGF1 NF1 ULK1 GSK3B TBC1D7 PTEN BDNF PMC4223653__F3 Neurology of mTOR TSC2 TSC1 NF1 ULK1 PTEN MTOR ULK2 PMC8137566__F7 Activation of Wnt/Beta-catenin signaling pathway induced by cooperative activity of ALK and N-Myc PTN ALK CSNK1E DDX3X LEF1 CTNNB1 PMC11489333__F8 Positive feedback for self-driving of NK-92AFR-CAR-CXCR3A cells based on IFNG and TNFA synergistically induced high CXCL10 expression STAT1 IFNGR1 CXCL10 PMC6787556__F4 NAD+ Depletion and Impaired Mitophagy Are Pivotal Events in Common Neurodegenerative Diseases FUS CDK5 SARM1 HEL-S-162eP BACE1 NAMPT NMNAT2 BDNF PARP1 PMC8282409__F2 New Insights on the Early Interaction Between Typhoid and Non-typhoid Salmonella Serovars and the Host Cells NLRC4 NAIP NLRP3 TLR4 GBP1 TLR10 PMC5372489__F2A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus PRKCE INSR SOCS4 SLC2A2 SOCS2 INS IRS1 PMC6787556__F1 Nicotinamide Adenine Dinucleotide (NAD+) Production and Catabolism in Mammalian Cells NAPRT HEL-S-90n NMNAT1 KYNU SLC22A3 NMNAT2 NAMPT SLC12A8 NNMT SARM1 SLC36A4 NADK NMNAT3 PMC9284792__F11 Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway RAF1 UBE3C YTHDF2 ACD POLR2A HEL-S-34 PMC8160143__F8 Bacterial and viral induced expression of IL22 SAA1 IF2B1 IL7 IL1A IL6 IFNB1 TNF PMC9164251__F1 Exploiting Extracellular Vesicles Strategies to Modulate Cell Death and Inflammation in COVID-19 STAT2 IFNAR2 IRF9 IFNAR1 IRF7 MDM2 ACE2 PMC536026__F1 Schematic of the Gp1 mGluR/FMRP pathway ADRBK1 PTEN PMC4671457__F5 A, B) Functional analyses of target genes of the differentially expressed miRNAs in MAPK signal pathway MAX ECSIT FAT4 EGF LTK JUN FAS RAF1 INA CD14 TNF TRAF6 SPN MOS NLK TRAF2 PMC6441662__F5 Fibroblast growth factor receptor 4 signalling pathway in cancer FRS2 FGFR4 GRB2 PMC7141219__F3 Upstream network analysis of the proteins from endothelial cells exposed to ponatinib and Notch-1 signaling inhibition JUN NR3A2 FOXO3A RELA NFKBIA PMC3663815__F7 Pathway summary of peptide array and antibody array results RHEB TSC2 BAD TSC1 FOXO1 BRAF PTEN MTOR INS IRS1 EIF4E PMC7641573__F5 Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway CDH2 CTNNB1 PMC9321501__F3 Investigating the molecular mechanisms of Tamoxifen on the EMT pathway among patients with breast cancer GABARAP MYLK KIF11 CDC20 PSMC6 PXN MCM10 NEK2 CHEK2 PML PLK1 PMC6600399__F2 Regulation and role of the PI3K-AKT-mTORC1 pathway in ribosome biogenesis and translation initiation MAX MAF1 RPS6 EIF4B LARP1 PTEN MYC DEPTOR RHEB TSC2 EEF2K POLDIP3 LARP6 MDM2 ELF3 PMC8667978__F1 Managing Antiphospholipid Syndrome in Children and Adolescents: Current and Future Prospects TF TLR4 PDC TLR9 TLR7 CS PMC9321501__F5 Investigating the molecular mechanisms of Tamoxifen on the EMT pathway among patients with breast cancer AURKA PLK2 CDC6 ECT2 KIF20A SOCS2 SOCS3 PTK2B PLK1 KIF23 KIZ MYLK BIRC5 KAT7 STAT5B C13orf34 AURKB PRC1 INCENP GINS2 CDCA8 SGOL1 CENPU PMC5577045__F8 Signaling pathways altered by XWL-1-48 BAX FAS H2AX ATM MDM2 PMC8722763__F6 Ailanthone suppresses the activity of human colorectal cancer cells through the STAT3 signaling pathway CDH2 CDC2 STAT3 BAX PMC3937030__F1 MTOR pathway signaling pathway ELF4 EIF4B PC EEF2 MTOR PMC2728865__F2 Transcriptional Regulation of Metabolism Associated With the Increased Desiccation Resistance of the Cactophilic Drosophila mojavensis HEL-S-162eP PDC PMC6045671__F1 Hippo pathway LATS1 FRMD6 WWTR1 LATS2 STK4 NF2 VGLL4 YAP1 PMC10670380__F3 Multi-level functional integration of extended regions of the human genome, above and beyond individual noncoding RNAs NONO APOE PMC5441763__F5 CD19 is the linchpin between CXCR4, the BCR, and the actin cytoskeleton CXCL12 SYK FOXO1 CD19 CXCR4 PMC12110894__F7 Expression changes of key enzyme genes for flavonoid synthesis pathway in different light treatments BIN2 MVD FDPS PMC3988961__F3 Pathway analysis LPA ATF3 TRO JUN JUND EGR1 SCARB1 GAS MAF ZNF365 GBP1 PID1 PMC4732882__F1 Metabolism and the circadian clock converge NAMPT SIRT1 PMC8997905__F2 Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases SYK SARM1 NLRP3 TLR4 FPR1 NOD2 TNF IL1B PMC11498046__F4 Preparation of PGRsEV-siYTHDF1 IFNG FZD7 SIRPA YTHDF1 CD47 CTNNB1 PMC10564423__F8 Schematic diagram illustrated how core fucosylation regulated alveolar epithelial cells senescence in pulmonary fibrosis through TGFB/Smad2/3 pathway in vivo and in vitro SMAD2 BLM PMC5360546__F4 Hippo pathway LATS1 PMC9480797__F3 Molecular pathways in glioblastoma-derived stem cells to identify effective drug agents: A bioinformatics study KIF15 DBF4 AURKA DKC1 CENPN MYBL2 ECT2 NEK2 KIF20A CENPE TERT NEK9 CCNA2 KIF23 FOXM1 CDKN2C C13orf34 CENPA KIF18A CCNB1 TOP2A SMC4 PMC7409586__F1 Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency SEPSECS EEFSEC SEPHS2 TRNAU1AP PSTK RPL30 NCL PMC4547750__F4 Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases DUSP3 MTOR TNF DUSP14 CDC25B DUSP7 PMC2735600__F7 Contribution of Rho to canonical Wnt3A signaling WNT3A APC GSK3B LRP5 LRP6 ARHA PMC10996135__F6 Distribution of common targets in the two most associated pathways MAX ECSIT SYK MYB EIF4B BAD FAS TRADD CD14 RBL2 PTEN CD19 TNF EIF4E RHEB TSC2 BCR CD37 NLK GCK MDM2 GRB2 PMC6356823__F2 Predictive pathway for polyamine synthesis in microalgal cells SMS DAP PMC7409586__F3 Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency SELE GC MCM5 PMC11868327__F3 Molecular cascade of the involvement of GluD2 or GluRD2 in cerebellar cell death BAX PC ATG5 PMC6828590__F13 Regulatory mechanism of the VEGF signal pathway in different groups CDC42 CASP9 BAD COX2 PIR SRC PMC4420611__F5 Lysosome pathway AGPS LAP3 ABCA2 UTY PMC6828590__F11 Regulatory mechanism of the PI3K-AKT signal pathway in different groups HEL164 SYK BAD GIP PTEN MTOR MYC BCR TLR4 MDM2 CCND1 CASP9 EIF4B GAL RBL2 CD19 RAC1 IRS1 EIF4E TSC2 TSC1 BRCA1 RXRA CDC37 GRB2 PMC6828590__F12 Regulatory mechanism of the MAPK signal pathway in different groups MAX ECSIT EGF SRI JUND FAS EGFR CD14 ATF2 TNF TRAF6 FLNA MEF2C NGF MOS NF1 PAK1 PC NLK BDNF TRAF2 PMC7952883__F3 General mechanisms of sildenafil in different types of cancer ABCC1 ARG1 MTOR ABCG2 KRAS ABCB1 CTNNB1 PMC4336821__F7 Bile Acids Regulate Nuclear Receptor (Nur77) Expression and Intracellular Location to Control Proliferation and Apoptosis CCND2 RARB RXRA RBBP8 CDK4 PMC6745167__F2 Results of network analysis: differentially regulated proteins from the SILAC approach are indicated in green (TCam-2) or in red (NTERA-2) ERBB3 TH EGF ALPL IGF1 PYGB LEFTY1 EGFR BCAM ERBB2 GGH SHE PMC5354081__F1 Examples of Metabolic Pathway Linking Gut Microbiota to Cardiovascular Diseases NLRP3 CD36 CYP7A1 CYP27A1 PMC11727624__F1 Biological processes of the canonical Hedgehog (Hh) signaling pathway ADRBK1 HHIP SUFU SMO HP KIN PMC4854486__F1 Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis GIP NALCN GIPR PMC5460031__F10 IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression PTX3 IL17RC MAML1 CXCL1 CCL7 TRAF5 TRAF6 S100A9 STEAP4 TRAF2 NOTCH1 CP PMC3155635__F3 Functional pathway analysis of the 12-gene genomic instability signature using Ingenuity Pathway Analysis TF RBM8 FOXA1 AURKA CCND3 CASP9 MYB IL10 CCL18 CD40LG TERT TNF MYC CDKN2A BCL2 MUC4 CCNB1 CASC3 HCTP4 CDK4 TNPO2 PMC7754529__F3 Co-expression pattern of the most significantly enriched pathways of differentially expressed genes involved in post-traumatic stress disorder TBK1 EGF GRIN2B PIK3CA PTPN5 FGF12 TGFA RAF1 SOS1 EGFR IKBKG MAP3K8 INSR PRKCA CHUK DUSP16 DUSP7 TAOK1 DUSP8 GNG13 CRKL NTRK2 PTPN11 KRAS RAB5A NFKB1 MAPK8IP2 PMC8160963__F1 Identifying Novel Actionable Targets in Colon Cancer TGFBR2 BAX IGF2R DCC APC BRAF SMAD4 KRAS PMC3082499__F5 Anti-apoptotic mechanisms of Akt RHEB BAX TSC2 BAD TSC1 MDM2 MTOR PMC8160963__F2 Identifying Novel Actionable Targets in Colon Cancer TRRAP BCL9 PAF1 BTRC TNKS APC GSK3B CTNNB1 PMC8160963__F3 Identifying Novel Actionable Targets in Colon Cancer SMAD2 SMAD4 TGFBR1 PMC4126409__F1 Pathways for HJ Resolution(A) Resolvases RuvC and GEN1 digest HJs to generate linear products with single nicks (carets) GEN1 SLX4 EME1 PMC3082499__F2 Mediators of the extrinsic pathway of PCD by Fas and TNFR-1 signaling FAS TRADD TNF FADD PMC321458__F8 Model of the role of RNase MRP in cell cycle control CIB2 XRN1 APC PMC8301371__F8 TLR7 Activation of Macrophages by Imiquimod Inhibits HIV Infection through Modulation of Viral Entry Cellular Factors STAT3 CCR5 TLR7 JAK1 TRAF2 TYK2 MYD88 PMC7461042__F2 HIF1 signalling pathway TF EGF TFRC HEL-S-133P HEL-S-162eP EPO IL6 HEL-S-87p VHL PMC6454084__F1 Putative palmitoylated proteins of the mechanistic target of rapamycin (mTOR) signaling pathway RPTOR FLCN MTOR RHEB MLST8 TSC2 TSC1 WDR59 NPRL2 C16orf35 TBC1D7 DEPDC5 SEH1L MIOS WDR24 PMC3116244__F1 Signaling Pathways Altered in Hepatic Cancer Stem Cells STAT3 BAD APC GSK3B FHL2 PTEN TERT MTOR IGF2 CTNNB1 IGF2R EPCAM CDX2 ADAM17 LEF1 CCND1 PMC6535055__F9 The mechanism graph of the regulatory network of PIEZO2 under different circumstance including normal (A) and cancer (B) CDON PIEZO2 PMC6839745__F1 Structure and treatment strategy of TAT-CLs-DHA/siRNA HMGB1 TLR4 IL1B MYD88 PMC7835870__F1 Metabolic conversion pathway from the essential omega-3 PUFA, ALA, to longer-chain omega-3 PUFAs, EPA, DPA and DHA ELOVL2 FADS2 ELOVL5 FADS1 PMC8280825__F1 Mitochondrial apoptosis pathway and opportunities for pharmacological inhibition BAX CGAS NLRP3 OPA1 PNPT1 PMC8137978__F1 Ferroptosis in Acute Respiratory Distress Syndrome SLC3A2 GPX4 SLC7A11 GLS2 PMC8553038__F2 Exosomes: Emerging Cell-Free Based Therapeutics in Dermatologic Diseases STAT3 TSPAN6 CD81 SMAD2 TSG101 PTEN MMP9 CTNNB1 CD9 HEL-S-162eP CD151 MMP2 TSPAN8 WNT4 CXCR4 CD63 SIRT1 PMC6177564__F2 Schematic illustrations of identified pathways in hepatitis C virus-induced liver carcinogenesis CTNNB1 PMC3093193__F2 Update on the regulation of mammalian melanocyte function and skin pigmentation EDN3 MC1R HGF NGFR DCT KIT TYRP1 NRG1 NGF SOX9 EDN1 POMC EDNRB PMC8315846__F6 MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture PTGIS IRAK1 HEL-S-1 TRAF6 IRAK4 MYD88 PMC5561186__F8 Schematic overview of effects of metformin on gene expression and metabolism in human adrenal H295R cells, focused on mitochondria and steroidogenesis UCP2 PCK2 STAR CYP17A1 ENO2 ENO3 GDAP1 ABCA1 COX6B2 ACSS1 PMC5576886__F1 Impact of Base Excision DNA Repair in Age-Related Neurodegenerative Diseases OGG1 LIG1 NEIL2 FEN1 PCNA MUTYH NEIL3 NEIL1 UNG POLE MBD4 TDG PMC3025761__F1 Schematic illustration of the various steps involved in the ubiquitin proteasome pathway and general architecture of the cullin 1 (CRL1) and cullin 4 (CRL4)-based E3 ubiquitin ligases RBX1 DDB1 PCNA SKP1 PMC2769052__F9 Schematic representation of a potential mechanism of IFN-Gamma- and STAT3-dependent cell growth modulated by TSC2/mTOR signaling pathway IFNG STAT3 TSC2 MTOR PMC7352671__F2 Sorafenib resistance EGFR CYP3A4 PMC7123108__F2 Cordyceps militaris adenine metabolic pathway PNP NT5E ADK ADA PMC6785598__F4 Epigenetic regulation of stem cells KLF4 TET2 ME2 PRC1 POLI TDG PMC8184806__F6 SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions HEL-S-102 ATF1 TNF PMC4880867__F1 Fzd7 receptor complexes and signalling output RNF43 ROR2 LRP5 ZNRF3 SDC4 LRP6 RYK WNT3 CTNNB1 PMC11360101__F7 Cytoscape shows the interactions between 9 major components of CSAEs and 4 known kidney injury pathways CDC42 RYR2 PLN STIM2 TRADD ORAI1 STIM1 MTOR ARHA DAO RAC1 OMD RIPK3 TLR3 TLR4 ROCK1 RIPK1 TRPC3 TRAF2 FADD PMC5549368__F1 Checkpoint inhibitors in melanoma and early phase development in solid tumors BRAF CTLA4 PMC3227454__F2 Epidermal growth factor and aging: A signaling molecule reveals a new eye opening function EGF INSR KRI1 EGFR INS PMC6485421__F1 NFKB and tumor-associated macrophages NOS2 IRF3 ARG1 IRF7 CXCL10 MYD88 PMC4328972__F1 Metabolic disturbance in the diabetic heart and prospective therapeutic targets FAS NR1C1 NLRP3 TLR4 PMC3391966__F1 Model of hedgehog action in the fetal male reproductive system SF1 PTCH1 DHH SHH PMC2778015__F3 Master regulator miRNA of oncogenic and tumor suppressor TP53INP1 CCNE1 BCL2 ATM MDM2 AATF PMC6065152__F2 Pancreatic cancer microenvironment participates in metastasis STAT3 LOX CX3CR1 TLR4 CXCL1 SHH QSCN6 CXCL8 PMC5677514__F1 Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme PIGC PIGF PIGN PMC3592971__F3 Four simplified signaling pathways STAT3 SMAD1 TNFRSF1B TGFB1 SMAD2 GSK3B SMAD4 MAPK9 SOCS3 CDKN2B MTOR MYC ATP2A1 TGFBR1 CTNNB1 GNAS ADCY8 DKK1 FZD1 CSNK1A1 HTR5A SP1 LEPR APC SMAD6 LRP6 DVL2 IRS1 BMP8A IKBKB AXIN1 AMHR2 CAMK2G TRAF2 PMC5085707__F1 Stages of cancer cell colonisation of the bone CASR CDH2 CXCL12 VTN IL11 VCAM1 CXCR4 PMC11836306__F1 TORC1 pathway in humans and yeast, derived from Refs3,19 SZT2 ITFG2 KICS2 FLCN CASTOR1 DEPTOR RHEB MLST8 TSC2 TSC1 WDR59 NPR2 DEPDC5 CASTOR2 FNIP1 MIOS WDR24 NPRC PMC3328638__F1 Glucose, fatty acid (FA) and glutamine metabolic pathways HEL107 HK2 TIGAR PMC6335266__F1 Simplified representation of the complement system, divided into pattern recognition molecules (PRMs), pathway specific and common components as well as inhibitors C6 CD59 C7 HEL-S-62p C2 C9 VTN CD46 CD55 C4A C4B_2 PMC7443478__F9 Sensitization of glutamate receptor‐mediated pain behaviour via nerve growth factor‐dependent phosphorylation of transient receptor potential V1 under inflammatory conditions AKAP5 NGF TRPV1 PMC7593681__F9 Potential mechanism of HBO treatment on intestinal barrier after SCI ROCK1 RHO PMC10796096__F1 cGAS-STING signaling pathway in amyotrophic lateral sclerosis (ALS) TREM2 TBK1 CGAS HNRNPA2B1 IRF3 SQSTM1 OPTN VCP HEL-S-44 C9orf72 PMC7664196__F3 Autophagy, Ca2+ and cancer ATG16L1 ORAI1 STIM1 ATG14 MTOR PMC7664196__F2 Apoptosis and Calcium (Ca2+) dynamics in cancer BAX FAS MCL1 BAP1 PML MCU PTEN APAF1 FADD PMC4136471__F2 Cellular and molecular interactions between HCL cells and their microenvironment CD44 CD40 CXCL12 SYK BTK BCR MSC CXCR4 PMC8632547__F3 Hippo Signaling Pathway: The Trader of Tumor Microenvironment TEAD2 TEAD3 CXCL5 CXCL1 IL8RB CCL2 TEAD4 PMC8632547__F4 Hippo Signaling Pathway: The Trader of Tumor Microenvironment LATS1 LATS2 TEAD2 TEAD3 RHO SRC TEAD4 PMC8632547__F1 Hippo Signaling Pathway: The Trader of Tumor Microenvironment LATS1 MOB1A TAOK1 TAOK2 TAOK3 NF2 VGLL4 PMC8632547__F2 Hippo Signaling Pathway: The Trader of Tumor Microenvironment LATS1 LATS2 RHO SRC PMC6304368__F7 Anti-HBV mechanism of TLR3 signaling of HSCs STAT3 TLR3 STAT2 IFNAR2 IRF9 IRF3 IRF7 HEL-S-70p TYK2 PMC6034666__F2 Engagement between the gut immune system and a probiotic (exemplified by Bifidobacterium longum subsp PDC TLR9 CCL20 PMC8632547__F5 Hippo Signaling Pathway: The Trader of Tumor Microenvironment LATS1 ROR1 LATS2 APC ROR2 RHO CTNNB1 PMC3481450__F6 Overlapping network between MCF-7 and ZR-75.1 cells TF VPS37D LCMT2 PMF1 ENY2 TIAL1 PMC4429670__F1 Vicious cycles in bone metastasis SOST DKK1 MTOR PMC8095092__F2 Cardiotoxicity of the BCR-ABL1 tyrosine kinase inhibitors: emphasis on ponatinib BAX BAD BCR BCL2 GRB2 GAB2 PMC6123311__F3 Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins POMC SOCS3 SH2B1 PMC7519200__F3 Innate immune system is the first line of defense against infection and injury and plays critical roles in the maintenance of brain homeostasis NLRP3 IL16 SIRT1 PMC5679168__F1 Contribution of BBB breakdown and dysregulated BBB transport to AD pathophysiology based on findings in animal models, as shown in and VLDLR PICALM PMC11046441__F3 Diversity of metabolic arrangements for Alpha-glucan and disaccharide pathways in the context of prokaryotes MAK MAL GC KIN PMC3514351__F1 Ingenuity pathways analysis summary HEL-S-107 PRF1 HYOU1 PENK PCSK2 LIPE LAG3 CP PMC6497837__F1 Schematic showing mechanisms underlying morphine tolerance JUN NLRP3 NEUROD1 TRPV1 TRAF6 PMC4094071__F8 AEG-1 regulation of HIV-1 neuropathogenesis IL18 YY1 TNF PMC7526653__F1 2HG metabolic pathway HEL-S-133P HEL-S-26 PMC6686482__F7 Schema presented the mechanism through which NOTCH1 aerobic glycolysis and signaling in PC cells were modulated by MACC1-AS1 PAX8 MMP9 NOTCH1 PMC11576191__F1 CaMKK2 signaling pathway CAMK1 GHSR CAMKK2 CAMK4 PMC8826371__F7 Graphical representation of the possible mechanism by which the stat4 genetic polymorphism affects HCC TG CYP2E1 FGL2 STAT4 PMC9194156__F2 Neurodevelopmental disorders, immunity, and cancer are connected STAT3 TIRAP IRAK1 IRAK2 TRAF6 TNF IRAK4 MYD88 PMC9194156__F5 Neurodevelopmental disorders, immunity, and cancer are connected FRS2 GRB2 MTOR DEPTOR PMC5794698__F1 Major communication pathways of the microbiota–gut–brain axis CCK PYY NPY PMC7526653__F3 Cystathionine metabolic pathway PHGDH SHMT1 CTH PSAT1 HEL-S-51e PSPH PMC3525110__F3 Proposed model for EA signaling CORT RAC1 MVK PMC5778870__F1 Interaction of miRNAs as oncogenic and tumor suppressor HRAS PTEN PMC2935335__F1 The highly simplified PI3K/Akt and MAP kinase pathways in thyroid cancer BRAF PTEN MTOR RET PMC4183711__F8 Diagram depicts a model in which Eya2 and Ebf3 are positioned in the gene regulatory pathway for the development of RGCs ONECUT1 ISL1 EYA2 POU4F2 EBF3 SOX11 ATOH7 PAX6 HES1 SOX4 HES5 PMC6646339__F7 Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke IGF1 MTOR PMC4755325__F1 CGAS-STING Defense Pathway and Its Counteraction by Viruses CGAS MAVS AIM2 IRF3 MYD88 PMC4755325__F2 The cGAS-STING Defense Pathway and Its Counteraction by Viruses TBK1 CGAS TRIM32 TRIM56 RNF5 ULK1 IRF3 RNF26 PMC9296991__F1 Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations NOS2 TLR4 SOCS3 PMC4769158__F11 Proposed mechanisms by which loss of TRAF2 in keratinocytes causes a psoriasis-like skin inflammation REL TNF TRAF2 PMC8431333__F5 Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression ARHGEF17 SUFU ARHA PMC9404709__F2 Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells SIRT3 AMT SIRT1 PMC3903161__F1 Steps of autophagy pathway activation ATG101 ATG3 ATG12 ULK1 ATG14 MTOR ATG5 PMC4325706__F3 Pathway Express analysis of the host response to IBDV infection in the spleen CASP9 BAD TRADD CASP3 EPO ATM TNF FADD PMC4325706__F4 Pathway Express analysis of the host response to IBDV infection in the bursa BOLL BCL10 BCR CD19 DAO PMC6939687__F2 Interplay between HIF-1A and Notch during hypoxia SOX2 NAMPT NRARP CP PMC4327822__F5 mGluR1/5 signaling pathways relevant to protein synthesis RHEB EEF2K TSC1 RAF1 ELF2 EEF2 PDK2 MTOR EIF4E PMC6781639__F2 VEGFR structures and their specific ligands VEGFB VEGFC PIGF NRP1 NRP2 VEGFA PMC8771846__F7 RhoJ facilitates angiogenesis in glioblastoma via JNK/VEGFR2 mediated activation of PAK and ERK signaling pathways PAK4 TNF PMC6989995__F1 Toll-like receptor 4 (TLR4)-KO aggravates dextran sulfate sodium (DSS)-induced intestinal damage by attenuating cell cycle and cytokine-cytokine receptor interaction TRO PCNA CDK2 ORC3 SKP2 TNF TNLG7C CA14 PMC6989995__F2 Toll-like receptor 4 (TLR4)-KO aggravates dextran sulfate sodium (DSS)-induced intestinal damage by attenuating TLR signaling pathways and enhancing the apoptosis pathway HTRA2 MAFK CAD ATM TEP1 ME1 TRAF2 IRAK4 FADD PMC8129546__F2 Gegen Qinlian Decoction Ameliorates Hyperuricemia-Induced Renal Tubular Injury via Blocking the Inflammatory Signaling Pathway PPARG IGF1R HTR2A CCL5 MTOR GH1 MYC CCL2 MAOA MAPK3 IL18 THBD MMP3 ABCG2 IL10 CASP8 GNB3 ADIPOR1 IL6 TNF NR3C2 NR1C1 FABP2 PON1 RELA CASP3 HAS2 XDH SIRT1 PMC10474119__F9 Mechanistic diagram summarizing the regulatory effect of TGR5 in mitochondrial dysfunction and neuroinflammation in Müller cells TBK1 CGAS PC IRF3 PMC8910147__F1 CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives CXCL9 CXCR3 CXCL12 CXCR6 CXCL5 CXCL1 CXCL16 ARG1 MIF CXCL10 CXCL8 FOS CTNNB1 CXCL11 CXCR1 PDC CXCR5 IL8RB CXCR4 PMC5727324__F6 DKK1–CKAP4 axis as a novel molecular target for cancer therapy and future perspectives CKAP4 DKK4 DKK3 DKK1 DKK2 PMC5727324__F4 DKK1 and CKAP4 signalling axis CKAP4 DKK1 PMC6295421__F5 Proposed mechanisms of nitrergic neurotransmission in the SIP syncytium VIP PDGFRA PMC5727324__F2 Polarized trafficking of Wnt proteins and receptors WNT3A DKK1 ROR2 WNT1 LRP6 RYK PMC5727324__F1 ‘Two endocytic routes and two outputs model’ in the Wnt signalling pathways WNT3A DKK1 APC ROR2 LRP6 TCF4 CTNNB1 PMC10505339__F2 NFKB signalling pathway LTB RELB TNF RUNX2 PMC10706418__F5 Analysis of hormone signaling transduction in response to CGMMV infection TF BIN2 EBF2 BAK1 PMC3091762__F9 IPA representation of the complement system pathway enriched in cluster 6, 3 hours post-infestation with P C6 CD59 C7 C2 CR2 C4A C4B_2 CR1 PMC10505339__F4 BMP signalling pathway SMAD1 DKFZp781O1323 SMAD6 SMAD4 PMC3091762__F7 IPA representation of the canonical pathway for leukocyte extravasation signalling in cluster 4, 24 hours post-infestation with P TEC CRK HEL-S-11 RHO PMC1570177__F1 Mathematical Modeling Identifies Inhibitors of Apoptosis as Mediators of Positive Feedback and Bistability BAX CASP9 CASP8 HEL-S-62p CASP3 C9 APAF1 PMC5659885__F2 Stretch-induced actomyosin contraction in epithelial tubes: mechanotransduction pathways for tubular homeostasis VASP ARHA SRC PMC8416109__F5 Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds EGFR GRB2 PMC9213757__F1 Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways BARD1 L3MBTL1 MRE11A SMARCAD1 BRCA1 RNF168 RIF1 PMC7832239__F1 Crosstalk between complement and coagulation cascade in COVID-19: There are 3 major self-regulating and overlapping pathways of complement activation system C7 HEL-S-62p C1S C9 PMC2956119__F1 This figure shows the two distinct but ultimately converging apoptosis signaling pathways in mammals BAX CASP9 FAS CASP3 APAF1 FADD PMC5595129__F1 An overview of roles of miRNAs as a regulator of DDR in response to radiation in cancers ATR RAD51 BRCA1 H2AX BRCA2 ATM SSB PMC2956119__F2 The many roles of FAS receptor signaling in the immune system CD40 FAS BCR PMC9503463__F2 NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity MAVS PMC6553925__F6 Summary of all identified phosphosites in LPS signaling pathway TBK1 TIRAP TAB3 CD14 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TLR4 IRAK3 TNIP2 TRAF2 PMC11395329__F6 MiR-27a-5p functions in hDPCs MAP3K7IP1 FSTL1 TLR4 RELA IRAK1 TRAF6 IRAK4 MYD88 PMC9503463__F1 NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity NLRP3 NOD2 IRF3 TRAF3 PMC8129546__F8 Gegen Qinlian Decoction Ameliorates Hyperuricemia-Induced Renal Tubular Injury via Blocking the Inflammatory Signaling Pathway BAX GSDMD NLRP3 PMC2373983__F1 Human T-Cell Leukemia Virus Type 1 Blunts Signaling by Interferon Alpha STAT2 IFNAR2 IRF9 IFNAR1 IRF1 ISG15 GBP1 PMC2956119__F3 The many roles of FAS receptor signaling in the immune system CASP9 FAS CASP3 APAF1 FADD PMC4149467__F6 GATA regulation of Notch signaling in the intestine LCT FABP1 ATOH1 MUC2 PMC8080387__F5 Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow–derived mesenchymal stem cells by regulating TP63 GSK3B TP63 PTEN CTNNB1 PMC10505339__F1 Interaction of Wnt/Beta-catenin and Wnt/Ca2+ signalling pathways in an inflammatory environment LRP5 LRP6 NLK CTNNB1 PMC8173139__F1 Radiotherapy and Cytokine Storm: Risk and Mechanism IFNG NLRP3 FPR1 TLR9 CXCL16 CCL5 CXCR4 PMC3064629__F6 miR-34a, MAGE-A genes, and p53 form a positive feedback loop modulating chemosensitivity in cancer cells MAGEA2B MAGEA12 MAGEA6 MAGEA3 PMC5733474__F2 Enriched PI3K/AKT signaling pathway, identified by Ingenuity Pathway Analysis based on 300 differentially expressed genes (nominal P values < 0.05) detected exclusively in both week 8 and week 12 topiramate (TPM) groups RHEB TSC2 BAD HEL-S-125m CCIN NFKBIE RRAS PTEN MTOR PPP2R5D CTNNB1 PMC6727394__F1 Altered metabolic pathways and associated circRNAs in cancer GLUD1 GLS HEL-S-133P FASN HEL-S-5 PMC6727394__F2 circRNAs and the Warburg effect associated signaling pathways STAT3 APC GC BCL2 IGF1R MTOR VEGFA CTNNB1 PMC7140961__F3 Metabolic pathway based on phenolic profiling CAD ACD PMC2575728__F2 Following the cytokine signaling pathway to leukemogenesis: a chronology EPOR JAK3 IL2RA JAK1 REL LCK PMC4066644__F2 Model of tumor heterogeneity PTCH1 SHH SMO PMC2583327__F10 Transcriptional and Translational Regulation of Transforming Growth FactorB Production in Response to Apoptotic Cells ARHA MTOR EIF4E PMC6199573__F1 Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A ATR TGFB1 PCNA BUB1B EGFR BRAF E2F5 SKP2 CCNB3 PTTG2 PRKCH CCND2 E2F4 E2F3 E2F6 ATM HEL-S-1 CCNB1 HDAC2 HEL2 YWHAG CDK4 E2F2 MAP4 APC SMC1A KRAS FOS PTTG1 CCNE2 MCM10 CDC45 MCM3 EP300 MCM2 PMC6721639__F1 After interacting with CD154, CD40 recruits and interacts with several adapter proteins, including TRAF1, 2, 3, 5 and 6 CD40 CD80 MAPKAP1 RELA RELB MEI1 TRAF5 IL6 PMC7334537__F1 Steroidogenesis including the classic androgen pathway (dark blue) and the alternative androgen biosynthesis pathway (light blue), both resulting in the synthesis of potent 5Alpha-dihydrotestosterone (DHT) POR CYP21A2 SRD5A2 CYP17A1 PMC8423434__AF1 Principles of signaling pathway modulation for enhancing human naive pluripotency induction LIF SRC RBPJ PMC5646231__F1 Regulation of Exercise-Induced Autophagy in Skeletal Muscle PINK1 ULK1 BNIP3 FUNDC1 MTOR ULK2 PMC151063__F9 p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop BAX DDR1 MDM2 PMC6332791__F9 A proposed model underlying the OTUB2/U2AF2 axis as an activator of the Warburg effect and tumorigenesis in NSCLC cells U2AF2 HEL-S-68p MTOR OTUB2 PMC6060714__F6 Valproic acid causes radiosensitivity of breast cancer cells via disrupting the DNA repair pathway RAD52 RAD51 BRCA1 BRCA2 PMC3529366__F6 BMP2-WNT4-FOXO1 pathway in HESC differentiation SMAD1 DKFZp781O1323 FOXO1 BMP2 LEFTY2 WNT4 BCL2L11 DCN SST CTNNB1 PMC4999430__F1 Interplay between EPEC/EHEC and inflammasome NLRC4 NLRP3 FADD PMC8437142__F10 Morphine-induced inhibition of moderate acute intermittent hypoxia-induced phrenic long-term facilitation (pLTF) TLR4 BDNF NACA PMC9622720__F4 Network exploration of gene signatures underlying low birth weight induced metabolic alterations SYK BAD GAL RBL2 PTEN CD19 MYC RAC1 IRS1 RHEB TSC2 BRCA1 BCR CD37 MEI1 MDM2 PMC8585600__F1 Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applications POR STAT3 TLR9 ACE2 PMC5485083__F2 Top Left: Gene expression networks activated whilst differentiating cells are treated with varying doses of escitalopram BMS1 RPL32 ANK2 DNTT GNL2 PWP2 PTPRN DLG4 DST CKAP2 DPF3 DCAF13 TNFRSF21 PMC9308265__F8 Chronic heat stress promotes liver inflammation in broilers via enhancing NFKB and NLRP3 signaling pathway NLRP3 TLR4 IL1B PMC8524770__F3 Sex hormones in lung cancer CXCL12 CXCR4 PMC8524770__F4 Sex hormones in lung cancer EGF IGF1 HRG MTOR PMC4279092__F2 Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis STAT3 EBI3 MTOR CD63 PMC3874419__F4 Cross-talk of EGFR/HER2 signaling with other pathways EGFR GSK3B PTEN HES1 CTNNB1 PMC10705939__F2 Schematic diagram of the regulatory pathways of K+ channels or transporters in Arabidopsis and rice HDAC10 BAG4 PMC5890100__F2 Whenever there is any inflammatory stimulus to the cell, there is activation of several molecular cascades such as NFKB, Nrf2, MAPKinase, JAK/STAT, p53, PI3K/mTOR, CREB, and Wnt/Beta catenin BAX CSA2 BAD KEAP1 JUNB RELB MTOR CTNNB1 MYD88 PMC5601168__F1 Wnt/Beta-catenin pathway in arrhythmogenic cardiomyopathy APC GSK3B LRP5 LRP6 CTNNB1 PMC5601168__F2 Wnt/Beta-catenin pathway in arrhythmogenic cardiomyopathy PKP2 GSK3B NF2 CCND1 CTNNB1 PMC3759561__F1 Regulation of Muscle Protein Synthesis and the Effects of Catabolic States TSC2 TSC1 IGF1 GSK3B PMC6265603__F3 Altered PI3K/Akt pathway during normal and insulin resistance OGA OGT PTEN PMC8688947__F1 High-Fat Diet-Induced Renal Proximal Tubular Inflammatory Injury: Emerging Risk Factor of Chronic Kidney Disease HDAC3 TGFB1 NLRP3 CHAC1 CD36 TLR4 CCR2 IL33 MTOR MYD88 PMC6265603__F1 Model-based in silico analysis of the PI3K/Akt pathway: the elucidation of cross-talk between diabetes and breast cancer RPTOR OGT IGF1 PTEN IGF2 PMC6769682__F5 Receptors used by chemerin, visfatin, resistin and apelin for their signaling pathways ROR1 CCRL2 CMKLR1 DCN PMC9001126__F7 Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway MSC MMP9 BAK1 PMC8963304__F8 Profiling Secreted miRNA Biomarkers of Chemical-Induced Neurodegeneration in Human iPSC-Derived Neurons TIMP1 HGF PTEN ITGAV NOX4 CTNNB1 ACTA2 TMSB4X CCND1 NOTCH1 CDK4 DDX5 SP1 AGTR1 VEGFA ITGB3 RAC1 FGF2 CD34 HRAS MAP3K7IP1 ITGB1 EDNRA NFKBIA EDNRB CDK2 PTH GRB2 PMC3569837__F2 Understanding metabolic regulation and its influence on cell physiology PFKFB4 KEAP1 F2 TIGAR PMC5930454__F8 miR-135b upregulated in BLBC represses multiple genes LTBP1 ROCK2 SMAD2 APC SMAD6 SMAD4 NODAL ARHA TGFBR1 BAMBI IFNG RBX1 SOST INVS E2F4 FST NOTUM RAE1 SKP1 NLK DAAM1 PMC8232957__F1 Cholesterol Metabolism as a Potential Therapeutic Target and a Prognostic Biomarker for Cancer Immunotherapy CD36 CCR7 IL8RB MMP9 XBP1 LAG3 PMC5735743__F3 MTG16, and other MTG family members, may play a role in the constitutive repression of both Wnt and Notch signaling pathways NRARP TCF4 MYC CTNNB1 PMC4816337__F1 Quantitative Modeling of the Alternative Pathway of the Complement System C6 CD59 FH C7 HEL-S-62p CR1 PMC5661630__F3 ZIP-mediated signaling pathways promote cell proliferation and metastasis in luminal and tamoxifen-resistant breast cancer cells STAT3 EGF EGFR GSK3B SRC PMC6151767__F27 Asymmetric aldol/lactonization sequence for the synthesis of spirooxindole dihydropyranones 93 BOC NBN SI PMC2217489__F4 F igure 4 RHEB PTEN MTOR PMC5661630__F2 Zinc deficiency in prostate cancer cells promotes cell survival via a phosphoinositide 3-kinase (PI3K) signaling pathway PCNA PTEN CDK4 PMC3864108__F1 Schematic diagram showing the interaction between NW arenaviruses and host innate immune response TBK1 TLR1 MAL IRF3 TRAF3 MYD88 PMC6626595__F2 Biosynthesis pathway of sialylation ST8SIA4 NANP ST6GAL2 ST3GAL6 ST8SIA5 ST6GAL1 ST8SIA6 ST8SIA1 CMAS ST8SIA2 ST6GALNAC6 NANS ST3GAL1 SIAT4C GNE ST6GALNAC2 ST6GALNAC1 ST3GAL5 ST3GAL3 ST6GALNAC4 PMC8770421__F2 Versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function BMP10 BMPR2 SMAD9 ACVR2B SMAD1 ACVR2A DKFZp781O1323 SMAD6 SMAD4 BMP6 ENG BMP4 BMP2 PMC6147150__F2 Pathway and network analyses showing major cellular processes associated with persistence of BD HEL164 STXBP4 AURKA TREM1 KRT10 TICRR LETM1 TNFRSF19 HEL-S-81p MPDZ ZWINT PLK1 TXN IQGAP3 IFNL2 PRR11 DSC3 KRT4 DUSP19 UACA JARID2 CP DEPDC1 CDC42 CKAP2L PTK6 SPRR3 TMPRSS4 STAP2 GTSE1 DGKA PRC1 KIFC1 TEF DIXDC1 KRT5 PTGER2 AQP3 NUF2 KRT14 PKP1 KNTC2 KRT3 PKP3 KIF18B IL17A KRT23 DSG3 EIF6 TUBA1C IL7 TMOD2 NPL HCTP4 PMC3607076__F3 ATM controls cellular survival in response to DNA damage through multiple pathways ATM MDM2 PMC12215033__F7 Schematic pathway illustrating the potential effect of curcumenol on Fc epsilon receptor I signaling SYK BTK FYN LYN GAB2 PMC3607076__F4 Selected summary of the ATM signaling network ATR H2AX ATF2 HMGN1 RIF1 MDC1 ATMIN TSC2 CEP63 RNF168 RNF8 ATM RNF20 PMC3983448__F4 Human epidermal growth receptor family members, the PI3K/Akt pathway, and targeted drugs COX2 EGFR CCR4 PTEN IGF1R MTOR PMC3042643__F1 EGFR signaling pathway EGFR PTEN GRB2 PMC3983448__F2 Molecular pathway for microsatellite instability+ gastric cancer BAX ARID1A PIK3CA XPO5 TARBP2 HDAC2 PMC2739295__F6 Gene Expression Profiling in Cells with Enhanced Gamma-Secretase Activity CD44 HEL113 SIAH1 GSK3B LRP5 LRP6 ARHA PROC PTPRG SPP1 CTNNB1 PMC7774932__F7 Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus PPARG NR1C1 FABP4 NR1C2 PMC8282058__F6 Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer’s Disease: Implications for Treatment IGF2R BACE1 APP IGF2 PMC7774932__F8 Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus PPARG NR1C1 NR1H3 FABP4 NR1C2 PMC3580541__F5 TRAF6 and TRAF2/5 signaling pathways CSA2 TRAF5 TRAF6 TRAF2 PMC7318778__F2 Dendritic cell metabolic reprogramming in tumor immune evasion HEL-S-53e IDO1 MSR1 XBP1 CTNNB1 PMC3898101__F8 Separate PI3K and Wnt signaling pathways APC AXIN1 CTNNB1 PMC8387852__F5 Gold nanoparticles enhance microRNA 31 detection in colon cancer cells after inhibition with chlorogenic acid BAX CGA SOX2 PMC3697618__F7 Diagram illustrating the phagocytic signaling pathway initiated by TLR4-linked JAK2 activation during the internalization of B CDC42 TLR4 CD14 LBP PMC5282884__F7 Illustration of interaction between NRIP2, RORB, and HBP1 NRIP2 TCF4 RORB CCND1 AXIN2 RORA PMC7358640__F1 Main calcium signaling pathways through Ca2+ channels and transporters involved in the regulation of calcium homeostasis in mammalian cells TRPM7 STIM2 ORAI1 STIM1 TRPC4 TRPC1 TRPM6 TRPM8 ORAI3 CA11 MCU TRPC6 TRPC3 TRPV6 PMC10831399__F3 NRP-1 gene expression generating axis of stem-cell properties LIN28B NRP1 PMC6099543__F7 Proposed biosynthetic pathway for nine ginsenosides ARAF RB1 F2 PMC4237243__F4 PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways CDC2 BAX RAD51 BRCA1 H2AX BRCA2 PMC12020991__F9 Schematic diagram of the molecular mechanism of PEDV hijacking CD4+ T cells for migration to the intestinal mucosa CDC42 MADCAM1 RAC1 PMC4888492__F1 Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle RPS6 BAD AKT3 IGFBP1 IRS4 PTEN PDK2 IRS1 TSC2 CBL TSC1 FYN FOXO1 GRB2 PMC4888492__F2 Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle TGFA AKT3 IGFBP1 PTEN GRB2 MTOR IRS1 PMC5665080__F2 Metabolic reprogramming associated with immune cell activation engages the mevalonate pathway ACLY FAS MTOR PMC5665080__F3 Inflammatory and immune responses to mevalonate pathway dysregulation IPP IL16 KRAS MVK PMC5665080__F1 SREBP-driven mevalonate pathway ACLY HMGCS1 ACAT1 IPP PDSS1 HMGCR PMVK MVD FDPS MVK PMC4237243__F5 PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways CDC2 BAX RAD51 BRCA1 H2AX BRCA2 MTOR PMC4053348__F1 Role of MALT1 in signaling to NFKB in ABC DLBCL CD79B SYK CD79A BTK PYY BCL10 BCR CARD11 IRAK1 CYLD IRAK4 MYD88 PMC6595388__F7 Signaling pathway ECSIT BAX TRADD RIPK1 TRAF2 FADD PMC3992846__F2 Production of biosynthetic precursors during glycolytic metabolism and their putative regulation during Xenopus tail appendage regeneration HEL-S-162eP SLC2A3 PMC4298731__F6 Cancer systems biology of TCGA SKCM: Efficient detection of genomic drivers in melanoma DVL1 GNAO1 MC1R CALML6 FZD10 GSK3B BRAF CTNNB1 GNAS ADCY8 EPHB2 CAMK2A CREB3L2 FZD3 NRAS PLCB3 ASIP DCT KIT TYRP1 KITLG EDNRB PLCB2 EP300 MAP2K1 PMC6028640__F1 Schematic overview of the pathway linking IMMP2L to senescence IMMP2L GPD2 SCCA2 PMC7292335__F1 Cbl-B in T-cell activation IL2 CTLA4 PMC4411085__F7 Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis FUS VCP CHMP2B PMC7937869__F7 Coronavirus N protein inhibiting IFNB production TBK1 TRIM25 IRF3 TRAF3 PMC2292467__F6 DNA replication and damage checkpoint regulation MRC1 PCNA CDC45 PMC4411085__F5 Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis FIG4 UBQLN2 VAPB VCP CHMP2B PMC11053446__F6 KEGG pathway analysis for DE mRNAs from cTECs infected with IBV DMV/1639 or IBV Mass41 CD40 CD80 TIRAP STAT2 CTSK TLR9 CD14 TLR5 IRF3 IRF7 TNF TRAF6 MYD88 CTRL TLR3 TLR4 TYK2 LBP FADD PMC9120667__F1 Metabolism and Endocrine Disorders: What Wnt Wrong? PRMT1 WLS PORCN DKK1 APC LRP5 LRP6 CTNNB1 PMC8224327__F2 Anti-Angiogenic Property of Free Human Oligosaccharides EGF VEGFC EGFR DLL4 VEGFA NOTCH1 PMC4258562__F1 Schematic presentation of the pathways involved in the inflammatory response during acute pancreatitis IL16 TLR4 MYD88 PMC1287678__F9 Putative signaling pathway of the evolutionarily conserved Toll/NFKB pathway utilizing the E ECSIT TRAF6 LBP IRAK4 PMC5429546__F4 KEGG analysis of upregulated and downregulated promoter DMGs showing involvement in a metabolic pathway CHSY1 ITPKA MTAP ALG10 HEL-S-278 DBH RDH12 PRODH TYMP OLAH PMC7004536__F3 Alterations in the oncogenic pathways in 88 NSCLC cell lines other than the CUL3‐KEAP1‐NRF2 system ARID1A STK11 EGFR PIK3R1 BRAF PTEN MTOR SETD2 RB1 CDKN2A ALK CCNE1 RBM10 NF1 PI3 ARID1B RIT1 NRAS ARID2 ATM MDM2 CCND1 SMARCA4 CDK4 ROS1 KRAS HRAS TSC2 TSC1 U2AF1 ERBB2 RET PMC7403894__F3 Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies TLR1 NLRP3 TLR4 HSF1 GSK3B TLR8 IRAK1 TLR7 TRAF3 ACE2 IL1B MYD88 PMC3547105__F1 The autotaxin-LPA-LPA1pathway LPA GAS PC PMC3782523__F1 Blocking the B7-H4 pathway with novel recombinant antibodies enhances T cell-mediated antitumor responses CD80 PMC9260869__F6 Downregulation of TNFR2 decreases survival gene expression, promotes apoptosis and affects the cell cycle of gastric cancer cells RP1 TRADD TNF TRAF2 PMC7403894__F1 Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies TLR1 NLRP3 TLR4 HSF1 GSK3B SIRT1 PMC3102606__F4 Pathway context for RME modules found in glioblastoma MKI67 CDKN2A NF1 EGFR SERPINA3 TARP ERBB2 PTEN EP300 MDM2 PMC2991311__F4 Systems Biology Approach Uncovers Cellular Strategies Used by Methylobacterium extorquens AM1 During the Switch from Multi- to Single-Carbon Growth RPE CAD HPR MAL WAS CS MICB ADA CIT PMC7014913__F2 Pathogenic alpha-synuclein transmission VPS35 LRRK2 SNCA PMC6113245__F1 Biosynthesis pathway of HBGAs FUT2 FUT3 PMC2800957__F1 Targets for lithium’s neuroprotective effects BAD MARCKS BDNF CTNNB1 PMC3492042__F8 MicroRNA targetome suggests aberrant upregulation of cell cycle regulators in AD brains RAD21 CDK7 PCNA CSK CDK2 MYT1 SKP2 ORC2 PMC11599740__F2 Activating insulin growth factors and energy deprivation triggers the HIF signaling pathway STRADA RHEB OGT TSC2 TSC1 NF1 RHO GRB2 IRS1 VHL PMC3492042__F5 MicroRNA targetome suggests aberrant upregulation of T cell receptor signaling pathway molecules in ATL cells CBL FYN LAT ITK GRB2 DAO LCK PMC8932107__F4 BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea GRB2 SHE BDNF PMC6862444__F2 GBM induction of PD-L1 secretion STAT1 IFNGR2 IFNGR1 EGFR VGF PTEN MTOR TRAF6 MYD88 PMC4419223__F3 Green tea modulates the various cell signalling pathways in cancer BAX LOX PTEN TNF PMC6880928__F1 Splicing the innate immune signalling in leukaemia U2AF1 IRAK4 MYD88 PMC4419223__F2 Role of green tea in cancer prevention through the modulation of genes involved in initiations, promotion, and progression of cancer BAX COX2 BCL2 PTEN PMC3492042__F3 MicroRNA targetome suggests aberrant upregulation of cell cycle regulators in AD brains ATR WEE1 MYT1 PMC10573510__F6 Asthma pathway CD40 MBP APC EPO TNF PMC5964147__F7 HMGA1 exacerbates tumor growth through regulating the cell cycle and accelerates migration/invasion via targeting miR-221/222 in cervical cancer TIMP3 CCNE1 HMGA1 MMP2 MMP9 CCND1 PMC3196058__F2 Dynamic Role of Beta-Catenin in Synaptic Plasticity CAD APC GSK3B PMC6938674__F8 Targeting CDK7 for treating Yap/Taz-driven cancer POLL CDK7 POLI PMC3317271__F1 Simplified scheme of cell death and survival pathways involved in ALF BAX ROS1 TNF TRAF2 FADD PMC8444356__F2 Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target CDH2 EGF MMP12 FGL1 EGFR MTOR PARP1 PMC4864964__F1 Processes involved in generation of the T cell-inflamed tumor microenvironment phenotype CXCL9 CD80 CXCL10 PMC11918971__F7 Aerobic exercise (AE) stimulates the synthesis of anti-inflammatory “muscle factors” such as IL-6, IL-10, and IL-1ra through skeletal muscle contraction while reducing the activity of proinflammatory factors such as TNFA IGF1 CRH BDNF TNF PMC4864964__F2 How tumor-intrinsic Beta-catenin signaling mediates exclusion of T cells from the tumor microenvironment ATF3 CD80 CCL4 CTNNB1 PMC8112849__F3 Melanogenesis signalling pathways MC1R CTNNB1 PMC3991209__F1 Diagram showing activation of Notch signalling HEY2 NOTCH2 NOTCH3 FURIN HES1 NOTCH1 PMC8081528__F9 The mechanism of Txnip-mediated cone rescue TXNIP LDHB PARP1 PMC8163614__F1 B2-Adrenergic receptor agonism as a therapeutic strategy for kidney disease MFN1 MFN2 PMC8082854__F2 Metabolic adaptation mechanism of metastatic organotropism STAT1 SDHB HEL-S-2a HEL-S-29 PC FABP4 GATA6 ASNS MTOR AKR1B10 PRODH TNF PMC8163614__F2 B2-Adrenergic receptor agonism as a therapeutic strategy for kidney disease WNK4 HDAC8 PMC5752449__F6 Proteasome and ErbB signaling pathway JUN BAD POMP MTOR ARC MYC IFNG CRK CBL RPN2 BTC RP2 GRB2 PMC7005787__F6 UPR activation and patient outcome in cancer ATF4 EIF2A XBP1 PMC6275018__F3 Representative model of leptin-induced EMT signaling STAT3 GRB2 PMC8836072__F3 Proliferation and Apoptosis Pathways and Factors in Oral Squamous Cell Carcinoma BAD BCL2A1 BMF HRK APAF1 BIK FADD PMC5752449__F4 Shared and specific mechanism of four autoimmune diseases CD40 TIRAP CTSK CPO IRF3 TRAF3 TRAF6 RAC1 MYD88 TLR3 PDC LPP FADD PMC5752449__F5 The shared and specific mechanism of four autoimmune diseases CDC42 BAD FAS CAD EGFR INS DAO FSHB RHEB TSC2 HBEGF TSC1 INSR MMP2 GRB2 GAB2 PMC7215987__F1 Phosphoinositide 3-kinase-Akt-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway RHEB TSC2 RICTOR TSC1 PTEN MTOR DEPTOR IRS1 EIF4E PMC7215987__F2 Main components and crosstalk between the Ras-Raf-mitogen-activated protein kinase-Ras- extracellular signal-regulated kinase (Ras-Raf-MEK-ERK) pathway, the spleen tyrosine kinase (SYK) pathway and the PI3K-Akt-mTOR pathway RHEB SYK TSC2 BAD TSC1 PTEN SRC DEPTOR IRS1 EIF4E PMC7449758__F7 Proposed action model for the PI3K/AKT/FoxO3a pathway via ROS regulating DNA damage in the lung, liver, and kidney induced by Nano-TiO2 intratracheal administration ROS1 GADD45A PMC3674381__F7 Model of XIAP as a switch between type I and type II signaling BAX PMC7468012__F1 Embryonic MTHFR contributes to blastocyst development SHMT1 MTR HEL-S-51e PMC8077906__F1 Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review ZAP70 MTOR LCK PMC3531868__F1 Receptors for IL4 and IL13 are comprised of four different subunits, IL4RA (green), gamma chain (Gc; purple), IL13RA1 (red), and IL13RA2 (yellow) IL13 IL13RA1 IL4 PMC3512134__F6 Overall organization of mitotic exit control CDC20 APC PMC7855837__F1 Elesclomol: a bis(thiohydrazide) amide compound that binds copper in a 1:1 ratio LOX DBH FDX1 HEL-S-44 PMC4316689__F2 Activation of RAS–MAPK pathway induces expression of numerous genes, some of which can be targeted TF EBNA1BP2 GOLT1A AURKA KIF11 AURKB CENPA HCTP4 WDR5 PMC2838081__F10 Molecular pathways regulated by C/EBPB during E-induced proliferation of uterine epithelial cells RAD18 ATR E2F3 CDK2 ATM PMC8229353__F1 Opposed Interplay between IDH1 Mutations and the WNT/Beta-Catenin Pathway: Added Information for Glioma Classification STAT3 HEL-S-133P APC GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC8229353__F2 Opposed Interplay between IDH1 Mutations and the WNT/Beta-Catenin Pathway: Added Information for Glioma Classification HEL-S-133P APC PIN1 CTNNB1 PMC4838196__F3 Phosphoproteome analysis links protein phosphorylation to cellular remodeling and metabolic adaptation during Magnaporthe oryzae appressorium development ATG10 GSG1 SLA2 ATG3 ATG12 PGM2 SNX4 ATG5 CAP1 PSD2 GDE1 PMC7273358__F6 Metabolic rewiring of the hypertensive kidney PPARG CCK ACSF3 CYCS DBT HIF1A ACD MYC MAPK8 ACADM MAPK3 MAPK14 ALB IFNG NLRP3 BCAT2 HEL-S-11 NPY CNBP GLB1 LPL ACOX1 ECHS1 ACADS SCD APOE HSD17B10 TRPV1 SNCA MIF PTK2B AKR1C1 VEGFA TNF FOS HMGCR IGF1 CDKN1A ACAT2 DLD APOB BCL2 VCAM1 EHHADH HGF TGFB1 LEP CD36 EGFR FGF21 NR1C2 RHO MTOR INS CRTC1 ABAT ACAT1 TLR4 TPM3 LDLR IL2 APP FOXP3 KNG1 CRP RPTOR IL10 JUN FASN IL4 EXOSC8 PRNP IL17A MMP9 PTGS2 RAC1 GCG IVD NR1C1 KRT12 PRL FOXO3A CASP3 NFE2L2 PTH PMC4167267__F7 Observed tumor patterns SF3B1 STK11 KEAP1 BRCA2 GSK3B POTEF BRAF PTEN TERT MTOR SETD2 ARHGAP32 CTNNB1 RB1 ETV6 NF1 FBN2 SMARCA4 APC ERG SYNE1 HRAS NKX3-1 RANBP2 FOXO1 NBPF10 CDKN1B MAP2K1 PMC8756109__F7 Vps34 Inhibits Hepatocellular Carcinoma Invasion by Regulating Endosome-Lysosome Trafficking via Rab7-RILP and Rab11 RILP EGFR PMC2195768__F6 Proposed signaling pathway of the purinergic receptor: regulation of cardiac autonomic activity TEC FYN PMC6419954__F6 G-protein mediated effects on smooth muscle tone regulation PKN1 CRAT GFAP CYFIP1 RHO UNK PMC3953345__F2 Schematic presentation of the molecular mechanisms of myogenic differentiation PAX3 MYOG MEOX1 MYF5 CTNNB1 PMC5649202__F2 Gene regulatory network (GRN) inferred for members from the NFKB pathway SYK PRKCI CARD10 CHUK BLNK ATM PMC9678096__F7 Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway SOX2 SIRT1 PMC5649202__F4 Gene regulatory network (GRN) inferred for members from the TP53 pathway CDC2 TP73 BAX PPM1D ATR FAS GADD45G PERP CD82 CYCS SFN EI24 DDB2 TSC2 IGF1 CCNE1 CCND2 GADD45B ATM RRM2B SESN1 MDM2 CCNB1 APAF1 PMC4633791__F1 Activation of effector and regulatory T cells by antigen presenting cells CD40 APC FOXP3 PMC4633791__F3 Induction of cell lines of spy cells into functionally distinct Treg lines APC IL5RA IRF4 FOXP3 PMC4633791__F4 Newly recruited CD4+ T-cell soldiers induced to be spies APC FOXP3 PMC4633791__F5 Activated and aggressive CD4+T cell soldiers convert to spies FAS FOXP3 PMC3974997__F2 Interference with the host NFKB signaling pathways by STPKs of pathogenic bacteria: LegK1, OspG, and NleH1 RPS3 RELB CRKL PMC4489880__F5 When pathways collide: collaboration and connivance among signaling proteins in development LATS1 FRMD6 LATS2 EGFR SHH NF2 PMC5723694__F7 TNFAlpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion IFNG STAT3 STAT1 PMC4489880__F4 When pathways collide: collaboration and connivance among signaling proteins in development LATS1 FAT4 LATS2 NF2 PMC4252843__F5 PROTEASE MEDIATED HUMAN SMOOTH MUSCLE CELL PROLIFERATION BY UROKINASE REQUIRES EPIDERMAL GROWTH FACTOR RECEPTOR TRANSACTIVATION BY TRIPLE MEMBRANE SIGNALING HBEGF EGFR ADAM12 ADAM10 PMC2202913__F1 Control of Food Intake by the Hypothalamic Leptin-Melanocortin PathwayThe hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis POMC ARC AgRP PMC4489880__F1 When pathways collide: collaboration and connivance among signaling proteins in development APC LRP5 LRP6 CTNNB1 PMC5723694__F3 TNFAlpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion SOCS1 IFNG IRF9 IFIT1 PIAS1 IRF1 IFI35 TNF PMC4489880__F2 When pathways collide: collaboration and connivance among signaling proteins in development RYK ARHA SRC PMC6302376__F5 Regulatory relationships between genes in a signal pathway regulating the TP53 gene ATM MDM2 PMC5667558__F1 microRNAs and lipid metabolism ATP8B1 LIPA ABCG1 ATG12 ALDH1A2 ATG5 ABCA1 PRKAA1 PMC7069501__F3 Therapeutic targeting of trained immunity NLRP3 CD36 NOD2 MTOR TNF IL1B PMC8138124__F1 New Faces of old Friends: Emerging new Roles of RNA-Binding Proteins in the DNA Double-Strand Break Response RBMX FUS PRPF19 RAD51 GEMIN2 CIRBP BRCA2 SFPQ WRAP53 MDC1 BLM PARP1 HDAC1 NONO DNA2 BRCA1 RNF168 SETMAR RNF8 ATM PALB2 RBM14 PMC9694773__F1 The Pathogenesis of Acute Porphyria Attacks and Increasing Hepatic PBGD as an Etiological Treatment FH CPO UROD UROS PMC8123490__F4 Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC TH TG NR1C1 LOXL2 CCR5 CCR2 PMC7415776__F1 Metabolic rewiring of cyanobacterial central metabolism with a synthetic acetate‐acetyl‐CoA/malonyl‐CoA (AAM) bypass for improved photosynthetic production of acetone from CO2 MAL GIP AIDA PMC2836122__F2 Cytokine signaling through the JAK/STAT pathway SOCS1 STAT3 STAT1 IFNGR2 IFNGR1 IFNAR2 LIF IFNAR1 SOCS3 PMC9227908__F4 Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches ISCU HK2 FASN MTOR PMC9227908__F1 Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches RPIA HEL-S-133P TIGAR MYC KRAS PMC6485631__F1 CD69: from activation marker to metabolic gatekeeper CD69 JAK3 PMC9099129__F3 Natural killer cells in liver transplantation: Can we harness the power of the immune checkpoint to promote tolerance? ZAP70 LCK PMC6643109__F3 In T2 DM rats, where the Hepatic Glucokinase (HGK) is lower, the level of lncRNA NONRATT021972 is increased GSK3B HEL-S-70p PMC3254042__F7 Signaling pathways involved in synaptic plasticity and neuroglia functions with associated molecules and cellular tasks (analysis based on Ingenuity IPA software) EGF BRAF PTEN MDM2 GRB2 MTOR PMC5070717__F1 GSK3B in TLR4 responses TBK1 MAP3K7IP1 TIRAP TLR4 GSK3B IRF3 TRAF3 TRAF6 MYD88 PMC5022960__F4 Regulating signal pathway related to gastric lipase (LIPF) and diacylglycerol kinase A (DGKA) in gastric cancer (GC) HDAC1 NPAS2 MYOD1 DGKA CEBPB LIPF PMC5070717__F2 GSK3B in TLR3 signaling TBK1 MAP3K7IP1 TLR3 GSK3B IRF3 TRAF3 TRAF6 PMC4575837__F2 Dietary restriction, mitochondrial function and aging: from yeast to humans TFAM SIRT3 FOXO3A EIF4E PMC7877093__F11 Five genes are indicated in red on the AGE–RAGE signaling pathway map after PGQYD treatment (red) TF BAX TG EGR1 SELE MMP2 IL6 CDK4 PMC9097084__F9 Transcriptional Profiling of Resistant and Susceptible Cultivars of Grapevine (Vitis L.) Reveals Hypersensitive Responses to Plasmopara viticola MYB ERF STS PMC3531794__F1 Impact of IL-27 on lymphocyte signaling pathways CXCR3 STAT3 STAT1 EBI3 AHR JAK1 TYK2 GATA3 PMC6835611__F7 Inflammatory signaling pathway and the resulting downstream responses IL13 VCAM1 MMP9 PMC7418786__F3 Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication STAMBP STAT3 PRKD2 SOS1 PXN EGFR WASL CTNND1 PIK3C2A MAPK14 CTRL AAK1 CLTA PRKCA SRC EPHX2 NCK1 SIK3 PAG1 PTPN1 BIN1 RPS6KA4 HDAC1 HGS CBL PACSIN3 ITSN2 AGFG1 OXSR1 CDC42BPB EPN1 ARHGEF7 MAP2K2 EPS15L1 ITSN1 PMC4314215__F4 MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy TNC HMGA2 ZEB2 ARHA MYC SOX4 RDX PMC5233753__F1 Schematized general estrogen signaling pathway DKK1 MTOR CTNNB1 PMC4646278__F8 Overview of the role of pioglitazone activated PPARG and ROCK inhibition on survival of dissociated single hPSCs GSK3B ARHA CTNNB1 PMC6766413__F4 μOR regulation of CXCR4 working modelMorphine or other μ-opioids binding to μORs on cortical neurons activates a GAi-protein pathway that leads to de-acidification of endolysosomes, and efflux of endolysosomal iron to the cytoplasm CXCL12 PAK1 LIMK1 CXCR4 RAC1 PMC9613808__F2 Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics TMPRSS2 MAVS IKBKE TLR9 IRF3 IRF7 TRAF3 TRAF6 IRAK4 BTK NLRP3 TLR3 TLR4 IFNAR1 TLR7 ACE2 PMC6562674__F1 Hedgehog signaling pathway SUFU PTCH1 SMO GLI3 PMC7057977__F5 COAD “cyan” module APOL6 subnetwork TAP1 CMPK2 IFI35 IL15RA GBP4 STAT1 HLA-E SP100 USP18 PSMB10 APOL1 PSME2 EIF2AK2 FAT10 BATF IRF1 IRF7 OAS3 CXCL10 RNF213 CXCL11 LAP3 HLA-B HLA-C HLA-A UBE2L6 IFIT1 IFIT3 IFIH1 PML IFIT2 TRIM21 IFI44L HLA-F CX3CL1 EPSTI1 MX2 MX1 TAP2 ISG15 TYMP OAS2 GBP2 PSMB8 BATF2 APOL2 DTX3L SP110 GBP1 XAF1 LAMP3 IDO1 NUB1 HERC6 ETV7 ApoL6 PMC7540116__F1 Metformin inhibits cancer invasion and migration via AMPK signaling pathway TSC2 TSC1 IGF1 IGF1R DEPTOR CCND1 PMC7540116__F2 Metformin inhibits cancer invasion and migration by blocking EMT signaling pathway STAT3 SMAD2 SMAD4 ZEB2 MTOR PMC7540116__F3 Metformin inhibiting cancer invasion and migration STAT3 TSC2 HMGA2 COX2 SMAD2 SMAD4 MTOR MYC PMC4659166__F7 Network of interactions between GWAS candidate genes using ingenuity pathway analysis (IPA) THOC2 DOCK7 CGN NME7 RSU1 CEP192 LATS1 LATS2 SEC16A LRCH2 OFD1 PLEKHG1 SIPA1L2 KIAA1549 PMC5757216__F1 Circadian clocks: from stem cells to tissue homeostasis and regeneration PER3 DBP PER2 PERP CRY2 CRY1 FBXL3 HLF RORB TEF PMC3110863__F4 Regulation of MeCP2 expression by Bdnf GRB2 BDNF PMC3927937__F2 Mixed-lineage leukemia FLT3 BRD4 APC CTNNB1 PMC9178375__F2 Gut microbes and muscle function: can probiotics make our muscles stronger? PYY IGF1 ULK1 IGF1R IRS1 PMC9477829__F1 Exosome biosynthesis and uptake pathways RAB31 CD63 PMC8889587__F6 Aberrant protein S-nitrosylation in ER stress-mediated insulin resistance ATF4 EIF2A ADA PMC3744831__F2 DDR-adapted model in meiotic silencing TOPBP1 ATR SPO11 H2AX ATM MDC1 PMC5188458__F1 Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer’s Disease PMC7569438__F10 Molecular mechanism by which Guttiferone K exerts anti-inflammatory effects in Mtb-infected macrophages NLRP3 COX2 TLR4 MTOR TRAF6 MYD88 PMC1874671__F2 Genomic organization of the CDKN2A locus and description of involvement of its transcripts (p16INK4a and p14ARF) in the Rb and p53 pathways CDKN2A CDK6 MDM2 CDK4 PMC2754694__F1 Transcriptional regulation of human CYP17 SIN3A SP3 SRC PMC6125039__F1 Human and yeast peroxisomal Beta-oxidation pathways ACOX1 AGPS GNPAT ABCD2 FAR1 BAAT AMACR POT1 PHYH PMC4584349__F1 Metabolites of the folate cycle, transsulfuration pathway, and methionine (Met)-homocysteine (Hcy) cycle CTH PC HEL-S-61p PMC11084589__F2 Inhibition of pathway activity induces microglial cell state transition TLR4 ARHA TRAF6 MYD88 PMC11084589__F3 Increased pathway activity induces a shift from a neurotoxic to a neuroprotective state in microglia CA3 TLR4 TRAF6 MYD88 PMC11084589__F4 Possible targeting pathway of ABA in PD CAMKK2 TLR4 MYD88 PMC11611323__F2 Metabolism of AdA DBP LOX ELOVL5 LBP ADA PMC8084697__F1 Type I and III Interferons in COVID-19 TBK1 MAVS STAT2 IRF9 IRF3 RSAD2 TRAF3 MYD88 STAT1 TLR3 TLR4 TLR8 TLR7 ISG15 JAK1 TYK2 ACE2 PMC11611323__F3 Action of AdA in NAFLD CD36 GPX1 ADA PMC6857111__F5 Coexpression network was constructed by WGCNA RGPD8 RGPD1 TH SFRS18 RAN ZBED6 CIRSR SKP2 PPBP SRM ITK DAP MXD1 USP34 DCUN1D1 RRM2 SNCA JMY BCLAF1 RANBP2 ZFYVE16 ALDH7A1 BMPER RGPD6 NIPBL PMC11913683__F4 CAT has anti-osteoporotic effects through other pathways IFNG STAT3 PKD1 COX2 GPX4 GSK3B BCL2 CYP1A1 RUNX2 SIRT1 PMC7359092__F1 Recent discoveries on the protective role of IL-22 against tissue injury STAT3 REG3G FGF21 BCL2 MTOR CCND1 PMC9325512__F1 CMTM6 and CMTM7: New leads for PD‐L1 regulation in breast cancer cells undergoing EMT SNAI1 CCL20 CD47 PMC3612515__F3 Graphical representation of Ingenuity Pathway Analysis results showing considerable overlap of the significantpredictor genes in the significant biologic pathways HSPG2 PANK1 SNX7 MTUS2 BRAF TYMS PPP3CA ITGAV FANCC TEAD4 E2F4 ARHGAP21 NOL3 WNT7A CEBPB YWHAG DYRK1B NAMPT ANXA1 KRAS YAP1 NR3C1 FGF2 CUL4A FOXO1 APBB1IP YWHAZ PMC4263413__F1 Transcriptome Profiles of the Protoscoleces of Echinococcus granulosus Reveal that Excretory-Secretory Products Are Essential to Metabolic Adaptation HEL-S-162eP HEL-S-87p PMC11913683__F2 Mechanisms by which CAT promotes osteoblast differentiation SMAD9 SMAD1 DKFZp781O1323 GSK3B SMAD4 MTOR TNF RUNX2 PKD1 IGF1 COX2 PTCH1 BMP2 SHH SMO S100A12 SIRT1 PMC11913683__F3 CAT inhibition of osteoclast differentiation BAX CTSK OSCAR PTEN NFATC1 SIRT6 PMC3612515__F1 Graphical representation of Ingenuity Pathway Analysis results showing significant predictors genes in ‘Gene Expression, Cell Cycle, Cancer’ pathway PRMT1 PYHIN1 RAD51 PANK1 ARL6IP1 ING5 PPP3CA CAMLG FKBP3 CKAP2 MAPK4 CPOX SEMA3C TP53AIP1 TRIM24 UNC5B PARP2 PMC8495591__F4 Blood glucose control contributes to protein stability of Ski-related novel protein N in a rat model of diabetes SMAD2 SMAD4 SMURF2 PMC3612515__F2 Graphical representation of Ingenuity Pathway Analysis results showing significant predictor genes in ‘InflammatoryResponse, Cell Death, Infection Mechanism’ pathway PYHIN1 CUL9 ARL6IP1 ING5 MED13L TGIF1 MAN2A1 FKBP3 RBX1 SEMA3C FBXW7 TP53AIP1 TRIM24 UNC5B PPT1 BAG6 DCLRE1A PMC4754720__F4 Metabolic regulation of mitochondrial transport and mitophagy RHEB OGT PGAM5 ULK1 FUNDC1 PMC4441389__F5 Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation GSK3B PTEN PMC7199713__F1 Herbal medicine on the intrinsic pathway of apoptosis BAX APC LRP5 LRP6 MTOR CCND1 CTNNB1 PMC7199713__F2 Herbal medicine on the extrinsic pathway of apoptosis CDC2 FAS TRADD CDK2 FADD MYD88 PMC4597337__F5 Molecular Mechanisms for High Hydrostatic Pressure-Induced Wing Mutagenesis in Drosophila melanogaster NEDD4 NUMB HEL-S-28 HP PMC6450213__F5 Gene network on chemokine signaling pathway by KEGG analysis of module-related DEGs CRK TIAM1 ELMO1 PAK1 ITK ARHA GRB2 SRC DOCK2 PMC2740411__F8 Transcriptional regulation of cell cycle arrest gene p21 by ZBTB5 BCOR SP1 ZBTB5 PMC3977821__F6 Robustness and Plasticity of Metabolic Pathway Flux among Uropathogenic Isolates of Pseudomonas aeruginosa SDHA SDHB SDHC TNLG7C PMC6425710__F1 Pericytes contribute in homeostasis of the BBB through different mechanisms CDH2 NGF DLL4 FGFR1 SMAD4 HIF1A NOTCH3 SRC NOX4 PMC6425710__F2 Under pathologic circumstances, pericytes present stemness or trans-differentiation potential CD44 GFAP SOX2 OLIG2 VCAM1 MAP2 CD34 PMC3418731__F3 Signaling within the JAK-STAT pathway in bovine monocytes and M STAT3 STAT1 IL2RB STAT2 IL16 IFNAR1 IL7R STAT4 IL1A GRB2 JAK1 TYK2 PMC8297548__F2 TIRAP in the Mechanism of Inflammation SOCS1 HMGB1 TLR1 BTK TIRAP TLR4 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC5820622__F2 Depiction of classical and nonclassical pathway to NF-kB (p65-p50 or RelBp52) translocation activation CD40 CSA2 RAF1 TRADD TIRAP RELB TLE4 TRAF3 TRAF6 IRAK4 MYD88 GRB2 TRAF2 PMC5472670__F1 The UPR signaling pathways ATF4 EIF2A XBP1 PMC5512418__F7 The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity LATS1 LATS2 MYD88 PMC1326326__F3 Proposed regulation of Cdc25A at the G1 and intra-S-phase checkpoints ATR CDK2 ATM PMC12105201__F8 SLC3A2 and SLC7A5 in the pathogenesis of OA SLC3A2 SLC7A5 MTOR PMC4259987__F2 Pathway analysis (STRING v9.05) of 39 proteins significantly dysregulated in the CSF of subjects with mild or moderate delirium relative to the mild AD control with no delirium HEL-S-2 NRCAM APOD APOE HRG SCG3 CLEC3B HBA2 APOA2 KLK6 NCAM1 APOH CHGB CLU BCAN APP FGA IGFBP7 HP CSTA HBB PMC3835199__F4 = Transporter, ◊ = Enzyme, ∇ = Kinase, ∆ = Phosphatase, = Transcription regulator, 〇 = Other, = Complex/group, = Peptidase GNB1 THRAP3 GABPB2 DYNC1H1 MTM1 CPAP PDE4B NRF1 INTS7 NDEL1 HTT CTXN1 PMC7078196__F6 Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation TSC2 IGF1R FURIN PMC8773838__F2 Janus Kinase Signaling Pathway and Its Role in COVID-19 Inflammatory, Vascular, and Thrombotic Manifestations JAK3 JAK1 PMC3674867__F1 Plasminogen Activator Inhibitor-1: The Double Edged Sword in Apoptosis BAX VTN PMC8469138__F6 Molecular Biology Networks and Key Gene Regulators for Inflammatory Biomarkers Shared by Breast Cancer Development: Multi-Omics Systems Analysis STAT3 GNAI1 GAL APOE GNAZ PRKCA APOB STAT4 PLTP JAK1 TYK2 NOTCH1 LCK PMC5467823__F6 Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer PLN ADAM18 ADAM11 BCL2A1 MMP21 ADAMTS7 ROR2 ADAMTS9 ADAM21 ADAM20 ADAM30 ADAMTS6 ECE2 ADAM22 IL36G ADAMTS2 PMC6952436__F1 Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment ZAP70 CD80 BATF CDK2 MTOR LCK PMC4594353__F1 Characteristics, regulators and effects of the epithelial-mesenchymal transition (EMT) CDH2 CTNNB1 PMC3565216__F1 Phosphatidic Acid Plays a Central Role in the Transcriptional Regulation of Glycerophospholipid Synthesis in Saccharomyces cerevisiae CDS1 GPT2 PC INS PSD2 PMC7859098__F4 m6A modification in immune-related bone homeostasis PTH METTL3 VEGFA TRAF6 PTH1R PMC9021207__F2 Associated immune metabolism in the tumor microenvironment ARG1 KRAS PMC9563138__F2 Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs ACLY HMGCR SQLE FASN PMC4354380__F1 Polycomb and trithorax proteins regulate chromatin structure and gene expression YY2 PRC1 SIRT1 PMC5104533__F2 An Immunological Perspective on Neonatal Sepsis REST HEL-S-5 IL1B PMC8458393__F8 Wuzi-Yanzong prescription alleviates spermatogenesis disorder induced by heat stress dependent on Akt, NFKB signaling pathway TYRO3 AXL EPOR EPO MYD88 PMC7426447__F2 Signal transduction of ginseng gintonin on the mammalian cell plasma membrane via LPA receptors, GPR40, and GPR55 LPA HEL-S-11 BDNF GPR55 PMC8486193__F4 Reactive oxygen species in cancer: Current findings and future directions BAX FAS MTOR APAF1 FADD PMC7426447__F4 Signaling pathway for gintonin-mediated autophagic influx via LPA1 receptor MTOR ATG5 HTT PMC5372489__F3A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus CRK CACNA1C PRKCE INSR SLC2A4 PIK3R2 MAPK10 ACACA KRAS TNF INS IRS1 PMC8922318__F5 Identification of the Potential Key Genes and Pathways Involved in Lens Changes of High Myopia MAX ECSIT FAS CD14 TNF TRAF6 FOS MEF2C PAK1 NLK PROC TRAF2 CDC25B PMC8922318__F6 Identification of the Potential Key Genes and Pathways Involved in Lens Changes of High Myopia TRDN PLN CAV3 CAV2 TNC HRC BCR PI3 MCU PMC7991738__F1 Apoptosis regulation via Cl− channels in ESCC cell SPAST CLIC1 ANO9 CLCN2 CFTR CNTRL PMC9371493__F8 Active compounds and molecular mechanism of Xuefu Zhuyu decoction for atherosclerosis, based on network pharmacology and molecular docking TF STAT3 SELE MMP2 PIN1 TNF PMC11729014__F13 Mechanism of action of NCOA4-mediated ferritinophagy-induced ferroptosis promoting endothelial injure CGAS APOE VCAM1 PMC3438185__F9 Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice FAS FADD PMC10377123__F3 Pharmacological Potential of Betulin as a Multitarget Compound KEAP1 GCLM GCLC MAF AHR PMC11279831__F1 IL-36 signaling pathway AP1S3 CARD14 CCL3 SERPINA3 IL36A PMC8665538__F5 Comparative analysis of aneurysm subtypes associated genes based on protein–protein interaction network NLRP12 NLRP3 CASP5 CASP4 IL18 IL1B PMC4211323__F1 Possible roles of Hsp90 in AD CDK5 TLR4 PMC9530810__F5 Comprehensive analysis of m6A-modified circRNAs in peritoneal metastasis of high grade serious carcinoma of ovary MAX NAT2 HPD MAFK FAS HEL-S-133P CD14 F11 SHE FLNA MOS HEL-S-11 PFKL SPX PMC6306698__F6 Pharmacological regulation of pluripotency circuitry establishment during cellular reprogramming via the FEN-stimulated PPARA regulatory pathway NR1C1 RXRA NR5A2 PMC4549768__F1 DNA damage tolerance mechanisms RAD52 RAD51 POLN RMI1 PMC4549768__F2 Regulation of DNA damage tolerance by proliferating cell nuclear antigen modification RAD18 PCNA POLN PMC3843373__F4 The PI3K pathway is the evolutionary conserved signalling pathway to ensure that growth and development is synchronised to the appropriate metabolic conditions: energy and substrate requiring processes only proceed when a ‘fed state’ is indicated BAD PTEN MTOR PMC7682023__F5 Schematic depicting genes in the PLC signalling pathway PLCG2 PLCL2 PLCB2 PMC9026965__F1 Vitamin D Impacts on Skeletal Muscle Dysfunction in Patients with COPD Promoting Mitochondrial Health NR1i1 PINK1 FIS1 RHOT1 MFN1 CS IL6 MTOR SIRT1 PMC9026965__F2 Vitamin D Impacts on Skeletal Muscle Dysfunction in Patients with COPD Promoting Mitochondrial Health NR1i1 MFN1 BNIP3 PMC10385528__F3 Anticancer mode of action of melittin on the essential molecular targets in different carcinomas STAT3 BAX MMP2 CCND1 PMC3700115__F7 Known and novel roles of the p38-MK2/3 signaling pathway in cross-striated muscles TF EGR1 SP1 NRF1 PMC5026795__F1 Recognition of C. albicans by pattern recognition receptors SYK TLR4 MAL IL4 TNF IL1B PMC9421066__F2 Crosstalk between sonodynamic therapy and autophagy in cancer ATG101 ATG3 ATG12 ULK1 NRBF2 MTOR ATG5 PMC2519092__F2 Cellular responses after six hours exposure to L TRH CDS1 ACD ARHA HLA-C HLA-A PMC9409683__F1 Regulatory Roles of Estrogens in Psoriasis TF GPER ERG PMC7035921__F3 miRNA regulation of miR-155 upon mycobacterial infection and dual role of miR-155 in the survival of mycobacteria SOCS1 RHEB GABARAP BACH1 ATG3 COX2 FOXO3A TLR4 MYD88 PMC8611092__F3 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression MOV10 TCF12 ZIC4 PMC8611092__F4 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression ITGB1 PTEN IGF1R MTOR PMC8611092__F2 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression BAD BCR RS1 PTEN MTOR PMC8611092__F5 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression NID1 RET PMC9672132__F1 Investigation of the physiological response of radiation-induced cystitis patients using hyperbaric oxygen MAPK1 NOS2 CXCL12 IL10 JUN CRH IL4 PTGS2 VEGFA IL1A IL6 CCL5 TNF PARP1 MAPK3 TFF2 HMOX1 CNTF NGF NTF3 F2 BDNF IL1B PMC3380339__F1 Cross-regulation between the IL-1B/IL-18 processing inflammasome and other inflammatory cytokines HMGB1 MAVS BCL10 CCL3 RAB39A AIM2 IRF3 CCL20 IL1B CARD9 PMC4395390__F3 Exploring Triacylglycerol Biosynthetic Pathway in Developing Seeds of Chia (Salvia hispanica L.): A Transcriptomic Approach FUS FAS FBL FASN FES AGL FARP1 PMC10304248__F2 Mycobacterium tuberculosis and apoptosis modulation BAX TRADD TNF FADD PMC10304248__F3 Mycobacterium tuberculosis and the necrotic-like cell death modulation ESX1 TRADD GPX4 MLKL TAB3 PTPA IRAK1 TNF TRAF6 MYD88 RIPK3 GSDMD NLRP3 HEL-S-69p NOD2 RIPK1 TRAF2 PMC3313983__F5 Associations between HIV and Human Pathways Revealed by Protein-Protein Interactions and Correlated Gene Expression Profiles STAT3 STAT1 EGF TGFA EGFR JAK1 PMC7379134__F8 Schematic diagram showing the crosstalk of the ASK1-JNK1/2 pathway and ER stress during DICD BAD BCL2 EIF2A XBP1 TRAF2 PMC9554302__F2 Advances in RIPK1 kinase inhibitors TRADD MLKL CYLD TRAF2 FADD PMC7158602__F7 The functions of OMT on inhibiting NP cells inflammation HMGB1 IL16 TLR4 TRAF6 MYD88 PMC7641301__F7 Over-regulated pathway after 48 h Forskolin stimulation TH JUN HEL113 PLEC EEF2 FOS LMNA PMC8874497__F2 Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer ACLY ACSS2 FAS ACO2 HMGCR CD36 PEMT LDLR ABCA1 PMC2998553__F3 Screen shot of the user interfaceofSimmune2.0 ZAP70 LAT RET PMC4133513__F1 Toll-like receptor signalling MAL TLR9 CD14 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 LBP PMC2912611__F8 From HLA-B27 to spondyloarthritis: a journey through the ER TH ERAP1 IL23R PMC8262388__F6 Interplay Between Mitochondrial Reactive Oxygen Species, Endoplasmic Reticulum Stress, and Nrf2 Signaling in Cardiometabolic Health FGF21 GDF15 ATF4 PMC2808058__F3 The effects of SOX4 and HOXC6 on Notch pathway activation and metastasis DKK3 TNC BMP7 ADAM10 PSEN1 SOX4 SFRP1 NOTCH1 WIF1 PMC2808058__F1 Schematic of the Notch pathway HES2 BMP7 ADAM10 PSEN1 NOTCH1 PMC2808058__F2 The effects of the SOX4 and HOXC6 transcriptional networks on PI3K-AKT pathway activation in prostate cancer IGF2R EGFR FGFRL1 SOX4 NOTCH1 CTNNB1 FGFR2 PMC7916951__F1 Multiple intracellular pathways triggered by Cytomegalovirus (CMV) and Epstein–Barr virus (EBV) infection converge on expression of proinflammatory cytokines and type I Interferon (IFN) response genes CGAS IRF2 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC1201514__F1 Regulation of the PIS1-encoded Phosphatidylinositol Synthase in Saccharomyces cerevisiae by Zinc CDS1 PSD2 PMC7858668__F2 Complement cascade and complement targeting therapies MASP1 C6 CD59 C2 DPP4 CD46 C4A C4B_2 PMC3268389__F1 Pathways and compartmentation of FA supply for TAG synthesis in plants FAS PC PMC3096054__F1 miRNA biogenesis pathways and regulatory networks AGO4 AGO1 AGO2 PMC7858668__F1 Complement in diabetic kidney disease CD59 HEL-S-62p CS PMC6856008__F6 MicroRNA Regulatory network with miRs from the anti-survival/EMT group SYK TIRAP SOS1 NFATC2 MCL1 GNG12 PTEN IGF1R LAMC1 TNR IKBKG PRKCB BAMBI BCL10 PLCG2 F2R TLR4 FGFR1 MDM2 NFATC4 APC NTRK2 IL7R VEGFA WNT7B CXXC4 FZD4 RELA ZNRF3 TRAF1 MAPK10 LYN GNG11 WNT8B LBP YWHAZ PMC5089367__F5 Targeted interactome of microRNAs (miRs) (miR-30c and miR-331-3p) GSK3B PMC7020042__F6 Schematic diagram showing D and DA on adipocyte differentiation through GSK-3B/Beta-catenin signaling in ASCs CEBPA FAS GSK3A APC CTNNB1 PMC5128196__F1 Huntington's disease pathway from KEGG database BAX LIPI REST SIN3A SP1 CASP3 TAF4 HEL70 PMC6341806__F2 Summarized molecular pathway of BDNF/TrkB's oncogenic role STAT3 EGFR BDNF PMC3443857__F1 Progesterone regulated paracrine signaling model depicted within the uterine compartments at the time of embryo implantation BMP2 MUC1 IHH WNT4 HAND2 PMC8469858__F1 Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer AXL RAC1 PMC7015852__F6 Water lily genome and the early evolution of flowering plants VIT POT1 NOTO PMC4076981__F8 Schematic drawing of the current model for the interrelationship between nutrient and light signaling in T GNB1 HEL-S-5 PHIP PMC7675406__F3 Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19 VWF ICAM2 CCR2 CCL2 PMC8814673__F2 Advances in research on the effects of platelet activation in acute lung injury (Review) MAPK1 SYK SRC TNF PMC5173167__F1 Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy CXCL12 CXCL5 PC ARG1 MMP9 MYC CCL2 IL1B PMC4479818__F1 Folate metabolic pathway MTHFD1 DHFR MTRR HEL-S-61p TYMS MTR PMC5584302__F2 PD1 signal transduction pathways in T cells ALB ZAP70 ITCH CDK2 PTEN PMC8710012__F1 Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis LATS1 LATS2 DKK1 AREG MYC CCND1 GATA3 PMC4939890__F2 Pathophysiological mechanisms involved in bicuspid aortic valve (BAV) SOX9 WNT3A BMP4 BMP2 LRP5 ARHA RUNX2 NOTCH1 PMC3705329__F1 SMAD/BMP pathway in hepatocytes TF TFR2 SMAD4 HFE PMC8710012__F4 Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis LATS1 LATS2 HEL-S-62p CDK9 PMC5378358__F6 Transcriptome analysis of Corynebacterium glutamicum in the process of recombinant protein expression in bioreactors MAL PC CIT PMC7300268__F1 Regulation of YAP/TAZ CDC2 AXL MARK4 ARHA MYC VGLL4 CTNNB1 LATS1 BIRC5 TIAM1 AMOT NLK NF2 CCND1 PMC8161467__F7 Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild-type TP53 colon and gastric cancer cells with aberrant KRAS signaling MDM4 FAS MDM2 KRAS PMC7606690__F4 Nef-mediated activation of Itk requires Nef homodimers ITK HEL-S-11 LCK PMC8720622__F7 LncRNA LINC00460: Function and mechanism in human cancer CCNG2 KDM2A EZH2 CTNNB1 PMC7352793__F6 ncRNAs involved in the IR-induced Wnt/Beta-catenin pathway TCEAL7 CTNNB1 PMC2254178__F1 Vital Elements of the Wnt-Frizzled Signaling Pathway in the Nervous System APC GSK3B CTNNB1 PMC8863344__F2 Reciprocal regulation of cellular mechanics and metabolism RHO SRC TRIM21 PMC3570203__F2 Genes highly expressed in TNBC compared to HR-positive, HER2-negative breast cancer HEL-S-22 DEPDC1 CDC20 MMP12 MYBL2 CENPE TYMS MAP2 PLK1 FOXM1 TACC3 SERPINB5 TUBA4A TTK KIFC1 TOP2A CENPF KNTC2 MKI67 PTTG1 AURKB HEL-S-162eP CRABP1 CHEK1 CENPA HCTP4 PMC3129465__F2 Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies TSLP TGFB1 CCL26 FLG WDR36 PMC3636031__F9 Early Apoptosis of Macrophages Modulated by Injection of Yersinia pestis YopK Promotes Progression of Primary Pneumonic Plague TRAF6 FADD PMC9204334__F1 Molecular Role of IL-35 in Non-Small Cell Lung Cancer STAT3 STAT1 EBI3 FOXP3 CTNNB1 PMC6468848__F2 The Notch signaling pathway CDK8 SOX2 CCND1 PMC6417835__F3 Architecture of the Fanconi anemia (FA) core complex, with FAAPs (Fanconi anemia–associated proteins) indicated by numbers FANCE FANCG FANCF REV1 FANCM FANCL FANCA UBE2T FANCC FANCB PMC6468848__F3 Functional effects of Notch-regulated miRNAs in glioblastoma UVRAG NOTCH2 DLL3 NOTCH1 PMC6417835__F4 Roles of FA proteins in replication stress ATR RAD51 RMI2 BRCA2 FANCM FANCL BLM UBE2T MCM7 MRE11A DNA2 BRCA1 MCM3 MCM5 MCM6 MCM2 PMC10840486__F9 Schematic illustration showing synergistic calcium supplementation and SIM delivery strategy for osteoporosis F3 BMP2 RUNX2 PMC6468848__F4 Other Notch-related tumorigenic aspects in the pathogenesis of Glioblastoma TRPM7 CHAC1 ID4 STC1 FOXG1 CTNNB1 PMC8002742__F3 The NLRP3 inflammasome pathway NLRP3 IL18 IL1B PMC8185253__F11 Assessment of Significant Pathway Signaling and Prognostic Value of GNG11 in Ovarian Serous Cystadenocarcinoma CD44 VWF CD36 DMP1 CHAD NPAT CD47 PMC3624769__F1 Interferon (IFN)-Gamma-activated pronecrotic and prosurvival signaling pathways STAT1 MLKL JAK1 FADD PMC8536488__F1 Cancer and Covid-19: Collectively catastrophic STAT3 TRADD TRAF2 FADD PMC6471380__F1 Molecular mechanisms of insulin functions and associated modifications in the hypothalamus STAT3 CCR5 PTEN SOCS3 CCL5 GPR17 PDE3B RICTOR TLR4 GPR78 POMC ATF4 AgRP PMC6858945__F1 Outline of the molecular pharmacology and response determinants of clinical TOP1 inhibitors TDP1 ATR MRE11A SLFN11 CHEK1 PMC8002742__F1 The activation of the Toll-like receptor signaling pathway TLR1 TIRAP TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 IRF7 TLR7 MYD88 PMC3309175__F7 Mammalian target of rapamycin (mTOR) signaling pathway for the regulation of skeletal muscle protein synthesis in response to growth factors, nutrition, and mechanical stimuli RPS6 ELF2 EEF2 MTOR PMC8002742__F2 Activation of type I interferon production via endosomal Toll-like receptors and RNA sensor signaling pathway in Sjögren’s syndrome TBK1 UNC93B1 MAVS TLR3 TLR9 IRAK1 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC4970451__F1 Migration of opioid-containing immune cells and opioid release within inflamed tissue CXCL8 IL1B PMC6237962__F3 Results of significant canonical pathways associated with ion-transport and the molecules involved RYR2 PLN ATR PMC6237962__F4 RNA sequencing-based analysis of the laying hen uterus revealed the novel genes and biological pathways involved in the eggshell biomineralization CREM CFTR SRC PMC8704918__F2 CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression MRC1 CCNC PMC8503187__F1 Biased Ghrelin Receptor Signaling and the Dopaminergic System as Potential Targets for Metabolic and Psychological Symptoms of Anorexia Nervosa POMC MC4R NPY ARC AgRP PMC2769253__F3 MicroRNAs in cancer E2F2 E2F3 MYC PMC3137003__F2 The insulin and leptin-melanocortin signaling pathway is responsible for maintaining energy and metabolic balance by controlling appetite POMC MC4R AgRP PMC2769253__F1 MicroRNAs in cancer DROSHA PMC8163825__F2 Key metabolic pathways in Hermodarchaeota genomes MAL AGA VILL PMC8997791__F2 Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases KEAP1 MTOR ATG5 PMC3433932__F3 The scheme summarizes the stretch-induced pathway that allows ROS scavenging in response to mechanical stimuli EGR1 SIRT1 PMC6639758__F3 An example of autocrine and paracrine interactions between NPY neuron (blue) and POMC neuron (green) in the ARC and their downstream effector neuron (i.e., neuron in PVN; beige) POMC MC3R NPY AgRP PMC2818158__F1 Inflammation at a molecular level: a simplified scheme TLR3 TLR4 MAL IRF3 TNF PMC5314324__F5 Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity PTMAP7 UBE2S CS PMC2315691__F1 Complement system and complement regulatory proteins (CRegs) MASP1 CD59 C2 CR1 PMC12217925__F8 CDH17-mediated regulation of LGR5 expression, Wnt signaling and drug resistance EPHB2 CDX2 CDH17 ABCG2 MYC GPR49 SLC38A5 PMC4253612__F3 Genes in cancer-related pathways ATF5 RAF1 EGFR NFKB2 APC GSK3B MMP9 TNF MYC CTNNB1 HRAS GRB2 SRC PMC4881561__F4 Notch signaling pathway and the localization of NSD1, BAP1, PDE4DIP and ATP10B in mesothelial cells PDE4DIP ATP10B NOTCH2 PMC6142509__F1 Activation and regulation of the alternative complement pathway HEL-S-62p CFI CFD CFH PMC5258846__F1 Microtubule motors drive Hedgehog signaling in primary cilia KIF7 SUFU SMO GLI3 PMC5155223__F6 Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma SRGAP2C ROBO1 SRGAP2 PMC1939900__F6 Different signaling pathway mediated by A3(IV)NC1 RELA MTOR EIF4E PMC4965087__F2 Pathways Underlying Distinct Cell Death Mechanisms in Two Human Lung Cancer Cell Lines in Response to SN1 Methylating Agents Treatment RFWD2 CASP9 ATR BAD FAS SIAH1 PERP PTEN MYC TSC2 CCNG1 CCNG2 CDR2 CASP3 CDK2 RRM2B MDM2 GADD45A PMC2582809__F1 Role of cytokines in DC and T-cell interactions APC FOXP3 IL23R PMC9709755__F3 Transcriptome profiling of colorectal tumors from patients with sepsis reveals an ethnic basis for viral infection risk and sepsis progression ARHG SHC1 MYH6 NFKB2 GSK3B PRKAG2 RPL38 PPP2R5C MTOR RPLP2 MAPK3 RPS16 ITGB6 VEGFB ACTA2 MAP2K6 PPP2R2B MYH7 ATF4 RND2 PPP2R5D RPTOR RPL12 PARVA MYH4 RPL7A HEL-S-28 RPL21 ITGB3 RPL23 RHOV RPL6 HEL114 RPS26 RPS24 EIF3E RPL13A CASP3 CREBBP RPL9 ACTG2 RPL26 CP PMC3109603__F7 Comparative pathway networks of cyclic genes in mouse, chicken and zebrafish NKD1 DACT1 TNFRSF19 NRARP DUSP4 DUSP2 AXIN2 ID1 DKK1 DUSP14 SP5 HES1 HES5 PMC12027552__F7 Correlation network diagram of differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) in the plant hormone signal transduction pathway under the FR treatment TF BIN2 EBF2 PMC6540516__F8 Evolution of erlotinib resistance in CD166+ OSCs EGFR TWIST1 PMC3997714__F1 Autophagy is involved in the initiation of hepatocarcinoma (HCC) MTOR EIF2A PMC9019486__F3 miR-874: An Important Regulator in Human Diseases STAT3 CXCL12 AQP3 APC TFAP2B YAP1 CTNNB1 LATS1 CDK8 LATS2 SUFU PTCH1 SMO HMGB2 AQP1 PMC4279367__F1 Under physiological conditions, ERK signaling is regulated by extracellular signals binding to receptor tyrosine kinases (RTKs) RB1 NF1 PTEN MTOR CDK4 PMC9692680__F5 Network Pharmacology- and Molecular Dynamics Simulation-Based Bioprospection of Aspalathus linearis for Type-2 Diabetes Care INSR HK2 EGFR RELA EP300 PRKCB PMC9644706__F3 FADD as a key molecular player in cancer progression BCL2 FADD PMC6281268__F9 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis CORT PC PMC6300493__F2 WW domain protein roles in genomic stability ATR ITCH BRCA1 WWOX ATM RNF20 SMURF2 PMC6281268__F6 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis ATR GSK3B WEE1 ATM MYT1 PMC6281268__F7 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis HTRA2 BAX BIRC6 FAS CAD MCL1 CYCS TNF DIABLO PMC6281268__F8 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis LTA UST TNF PMC6300493__F7 E3 modulate breast cancer cell invasion and metastasis WWP1 EGF SMURF1 ITCH EGFR SMURF2 USP9X CXCR4 PMC6431671__F7 Integrative pathway enrichment analysis showing the interaction between predicted and experimental targets ITIH2 HEL-S-72p SERPINC1 SERPING1 ORM1 SERPINA1 HRG SMAD4 VEGFA LSM6 CTNNB1 EEF2 A2M APOB HP ADCY1 CREB1 ITIH4 PMC6300493__F6 E3 ligases regulate breast cancer cell proliferation WWP1 WBP2 SMURF1 ITCH AMOT LRP5 LRP6 SMURF2 PMC6300493__F4 Inactivation of the Hippo pathway induces breast cancer metastasis LATS1 ABI2 MOB1A NSUN6 LLGL2 ABL2 MARK4 SKI PMC5519339__F2 CREB-induced IL-10 production is regulated by IFNG SP1 GSK3B PMC3365841__F16 GPCR-modulated channel activity in pituitary cells VIP TRH CRH GHRH NACA2 ERG PMC7399097__F3 Interleukin-17A signaling transduction pathway TRAF4 IL17RC BAD CAD ARID5A TAB3 TRAF6 DDX3X TRAF2 PMC4309263__F6 Schematic representation of the reciprocal auto-sustaining loop between Jagged1 ligand and Notch3 receptor in T-ALL ADAM17 ADAM10 NOTCH3 NOTCH1 PMC3365841__F11 Pituitary cells express GPCRs that engage the cAMP signaling pathway VIP C2 CRH GHRH SST PMC2872116__F1 Analysis of a protein interaction network in the context of the T-cell pathway JUN MAPK12 REL FOS LCK PMC2872116__F2 Structuring protein interactions around familiar canonical pathways provides intuitive visualizations RAN NPAT REL LCK PMC11577955__F8 Mechanisms underlying the tryptophan metabolic pathway TDO2 DLD AFMID DDC PMC5841164__F1 PTEN signaling in Treg cells FOXO1 APC NRP1 PTEN FOXP3 PMC11411235__F4 Functions of tetraspanins in PC TSPAN1 STAT3 TET2 VEGFC TSPAN8 MMP9 SRC TSPAN7 FAM3A PMC11411235__F5 Functions of tetraspanins in CRC TSPAN1 TSPAN9 TSPAN6 TSPAN12 TSPAN8 TSPAN5 PMC11411235__F2 Functions of tetraspanins in GC TSPAN1 MMP7 TSPAN9 EGFR TSPAN31 TSPAN8 TSPAN5 PMC11411235__F3 Functions of tetraspanins in liver cancer TSPAN1 TSPAN15 GSK3B TSPAN31 ADAM12 TSPAN8 TSPAN5 MMP9 TSPAN7 CDK4 PMC4667402__F2 Comprehensive illustration of transcription changes in skeletal muscle of red cusk-eel under handling stress using modified KEGG pathway maps using Pathvisio v3 TMOD1 UBE4B MYOD1 HEL113 UBC HEL-S-273 SMAD2 UVRAG TNNT1 HERC2 TPM1 RPN2 ATG12 tmp_locus_29 PRH2 TPM3 RPN1 HEL-S-108 DMD ULK2 PMC3110626__F1 Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome PIK3CA BAD PIK3R3 PIK3CD PIK3R2 AKT3 PIK3R1 RBL2 PTEN TERT MTOR PIK3R4 MDM2 CCND1 PMC9136039__F6 Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer EECP CXCR1 GAS APC IL8RB TFF3 PIGR CXCL8 CXCL3 PMC10135467__F2 Illustration of the regulatory network of METTL3 in the nervous system FXR2 ERFL SOX2 EZH2 NPAS4 ARC BDNF TRAF6 DLL3 PMC8750188__F3 Identification of Let-7 miRNA Activity as a Prognostic Biomarker of SHH Medulloblastoma LIN28B LIN28A PMC8566343__F10 Comprehensive Proteome and Acetyl-Proteome Atlas Reveals Molecular Mechanisms Adapting to the Physiological Changes From Pre-laying to Peak-Laying Stage in Liver of Hens (Gallus gallus) EHHADH CAD KY CROT F2 HEL-S-11 PPA2 AADAT ADA PMC9582773__F2 Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease CRP TMPRSS2 KEAP1 TLR9 TLR7 TNF MPO PMC2933676__F3 The canonical Wnt signaling pathway LRP5 TEF CTNNB1 NDP PMC6369205__F11 Regulatory role of GRK2 in TLRs-mediated signaling pathways for iNOS expression in microglial cells ADRBK1 STAT3 STAT1 TLR3 TLR4 TLR9 IRF1 PMC9355054__F1 Systematic review: Molecular docking simulation of small molecules as anticancer non-small cell lung carcinoma drug candidates EGF EGFR PTEN GRB2 PMC3364993__F5 Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes EGF EGFR SRC PMC9323107__F2 Need for Individualized Risk Assessment in Cardiovascular Disease TFPI PLG PMC8469784__F8 Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals—An Overview AANAT ASMT PMC5372366__F4 Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus TGFBI SPARC PSAP PMC9664769__F5 Disinfectant dodecyl dimethyl benzyl ammonium chloride (DDBAC) disrupts gut microbiota, phospholipids, and calcium signaling in honeybees (Apis mellifera) at an environmentally relevant level CAV3 DMD BDNF PMC9575643__F2 Cellular, molecular, metabolic and epigenetic approaches to studying trained immunity TLR4 TNF IL1B PMC6791490__F3 Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches TH TRH TSHR AHR TPO TRHR PMC4543340__F1 HGF/MET signaling pathway HGF GAB2 PMC8790411__F1 Biomarkers for response to immune checkpoint inhibitors in gastrointestinal cancers CXCL9 TET1 MDM2 POLE PMC3791171__F4 Molecular pathogenesis and mechanisms of thyroid cancer TG TSHR BRAF TPO PMC3791171__F1 Molecular pathogenesis and mechanisms of thyroid cancer TIMP3 TGFB1 TSHR FOXO3A TPO HIF1A VEGFA SLC5A8 PMC3791171__F2 Molecular pathogenesis and mechanisms of thyroid cancer FOXO3A GSK3B PTEN MTOR CTNNB1 PMC4658327__F1 Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation OGT RENBP GNE EGFR GC COCH MUC1 NPL PMC4252768__F2 Wnt5a: A Player in the Pathogenesis of Atherosclerosis and other Inflammatory Disorders STAT3 ROR2 PMC9706101__F2 Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors TSC2 WNK4 SGK1 FOXO1 FOXO3A NFAT5 TNF IL23R PMC4252768__F1 Wnt5a: A Player in the Pathogenesis of Atherosclerosis and other Inflammatory Disorders APC ROR2 LRP5 LRP6 RHO CTNNB1 PMC3593299__F1 Ghrelin neuroprotective pathways in Parkinson’s disease UCP2 TFAM GHSR PINK1 LRRK2 ULK1 MTOR PMC3816228__F2 Receptors involved in allergen recognition and uptake by AECs SYK TSLP TLR4 EGFR CCL20 PMC5831949__F3 Key biological pathways with DNB genes in cytokine-cytokine receptor interaction and PPAR signaling pathway PRLR IL19 EGF LTA FAS LEP OSM INHBC CCR2 CCL2 MPL CCL23 INHA OSMR IL17RB SI KDR AMH GHB2 GHR UBC LEPR LIF SP7 HEL-S-28 TNF TNLG2B CNTFR TSLP PIGF CCL25 IL7 EDAR TNLG7C PMC9126461__F1 Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features RASSF1 BRAF GRB2 RAC1 PMC5796257__F1 Deregulated frizzled (FZD) in Wnt/Beta-catenin signaling SOX9 ELL CTNNB1 PMC7981598__F5 Description of 3 overlapping-pathways for complement activation: The complement: opsonin C3b, anaphylatoxins C3a and C5a (complement peptides), and membrane-attack complex (MAC, C5b-9), produced by all three pathways HEL-S-62p C2 PMC8543968__F6 Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium STIM1 EGFR MCU CDK4 PMC6188668__F7 Arid5a in the IL-17R signaling pathway IL17RC ARID5A CEBPB TRAF2 NFKBIZ PMC9470149__F2 The CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications JAK3 CCR2 MTOR CCL2 PMC9010225__F2 Emerging role of PARP-1 and PARthanatos in ischemic stroke TRPM2 PARG MIF PMC2947178__F8 Model for the Coordinated Action of the Mating Types to Regulate Different Stages of Pathogenic Development of U CLP1 PRF1 PMC10989365__F6 CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway CALD1 PTEN PMC8789681__F1 Resistance to Dopamine Agonists in Pituitary Tumors: Molecular Mechanisms TGFBR2 TPT1 SMAD2 RHO FLNA TGFBR1 PMC5927358__F1 Canonical Wnt signaling pathway RNF43 APC LRP5 ZNRF3 LRP6 PMC7981598__F2 Status of mannose-binding lectin (MBL) and complement system in COVID-19 patients and therapeutic applications of antiviral plant MBLs ATR ACE2 PMC5927358__F3 Wnt/TOR and Wnt/STOP signaling pathways TSC2 APC GSK3B LRP5 LRP6 PMC5671492__F7 Biphasic concentration-dependent regulation of Cav-1 gene expression and GSK-3B activity by fluoxetine in astrocytes EGF EGFR GSK3B SRC PMC5831797__F2 Schematic depiction of the cross-talk between Hh signaling and DYRK kinases DYRK2 DYRK1A PTCH1 MAL DYRK1B SMO GLI3 PMC6771624__F5 KEGG pathways for TCA cycle and retinol metabolism in the T 6 vs CYP1A2 SDHD UGT1A9 FH ACO2 IDH3B LRAT DHRS4 HEL-S-32 RETSAT PMC7397755__F1 Lineage plasticity in cancer: a shared pathway of therapeutic resistance RB1 EGFR NKX2-1 SOX2 EZH2 MYC KRAS PMC8979719__F7 Comparison of Three Species of Rhubarb in Inhibiting Vascular Endothelial Injury via Regulation of PI3K/AKT/NFKB Signaling Pathway AURKA STAT3 PPARG PIK3CA EGFR TERT MTOR MMP15 MPO POR ALB ADAM17 MMP2 ALOX12 MDM2 SRC NOS2 KIT PTGS2 MMP9 VEGFA IL6 TNF FGF2 ERBB2 BCL2 SELP PMC7476343__F1 Representation of the reciprocal links between cancer and thrombosis TF VWF APC PC PMC6144451__F7 The effects of CLN3, flupirtine, retigabine, and benzyl (compound 5) or allyl (compound 6) carbamate derivatives on ceramide synthesis and intrinsic/extrinsic apoptotic pathways BAX FAS CERS2 DEGS2 SMPD1 CLN3 CERS6 FADD PMC4744706__F2 Key players of the mTOR complex1 cascade in LR asymmetry Cartoon depicting a simplified model of the TORC1‐dependent signalling pathway and its physiological outcome TSC2 TSC1 ULK1 GSK3B ATG14 PMC9317563__F1 Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms CD40 CD80 SYK TLR9 TCF4 TRAF3 MYC TRAF6 MYD88 RB1 ETV6 NLRP3 MHC2TA SPIB NRAS ZEB2 SRC AXL HES6 POLI AIM2 EZH2 IRF3 IRF7 CTLA4 IRF8 TNF ICOS BCL2 TET2 SF3B1 ZRSR2 CD27 MTOR RUNX2 BTK PIG59 TLR4 ATM TLR7 IKZF1 BLNK BCL11A KRAS CD47 TIGIT TLR3 SIRPA NFATC3 PMC5795054__F1 Scheme of the biosynthetic pathway downstream to phenylalanine FH PAH PMC5336482__F2 Involvement of GSK3 in TLR4 signaling pathways.Activation of TLR4 by LPS or alarmins (called ligand in the figure) involves dimers of TLR4 binding to CD14 and MD-2 TBK1 TLR4 CD14 IRF3 TRAF3 TRAF6 MYD88 PMC3407815__F1 The interleukin (IL)-12/IL-23/interferon (IFN)G pathway and its role in mycobacterial disease control CD40 STAT1 IRF8 JAK1 PMC9179367__F1 Supplemental Nicotinic Acid Elevates NAD+ Precursors in the Follicular Fluid of Mares NAPRT NAMPT SLC5A8 PMC8067156__F2 Pathophysiology of Ulcerative Colitis CXCL1 IRF4 FOXP3 CXCL10 CXCL8 GATA3 CXCL3 PMC8502484__F1 Parallels Between the Antiviral State and the Irradiated State CGAS MAVS STAT2 IRF9 TLR9 AIM2 IRF3 IRF7 TRAF6 MYD88 STAT1 TLR3 TLR8 TLR7 PMC9467317__F4 TI2-induced subnetwork BAX CSA2 CASP9 CBX2 TRADD MLKL TNF tmp_locus_29 CASP3 APP PROC CYLD CP FADD PMC9065611__F5 Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto HMBS CPOX ALAS1 ALAS2 FECH UROD UROS PMC8434535__F11 Protective Effects of Sal B on Oxidative Stress-Induced Aging by Regulating the Keap1/Nrf2 Signaling Pathway in Zebrafish CRYZ MAFK CCS SIRT3 TXN EIF2AK4 BACH1 HEL-S-2a NQO1 GCLC NRF1 EIF2AK2 HEL-S-44 HEL-75 PMC11705637__F4 Main pathways involved in INPP5E activation AURKA SUFU INPP5E PMC8160090__F1 JAK-STAT in Early Hematopoiesis and Leukemia STAT3 CXCL12 STAT1 LEPR JAK3 TPO CLPS JAK1 TYK2 PMC9467317__F1 TNFR1 signal transduction pathway TRADD C2 MLKL TNF CYLD TRAF2 FADD PMC8979819__F8 Schematic summarizing the effects of Gab2 on RTK expression and signaling in Flt3-ITD positive AML AXL GFRA2 GAB2 RET PMC1361319__F1 Scheme of branch pathways of phenylpropanoid metabolism in plants leading to the synthesis of anthocyanins, flavonols, PAs, and lignin CAD HEL-S-62p PMC4618268__F1 Everolimus Combined With Gefitinib in Patients with Metastatic Castration-Resistant Prostate Cancer: Phase I/II Results and Signaling Pathway Implications FKBP5 EGFR IGF1R PMC11653102__F8 AD-like neuropsychiatric dysfunction in a mice model induced by the combination of high-fat diet and intraperitoneal injection of streptozotocin TREM2 TREM1 TNF IRS1 PMC8226009__F4 N6-Methyladenosine RNA Methylation Regulator-Related Alternative Splicing (AS) Gene Signature Predicts Non–Small Cell Lung Cancer Prognosis TH POLL CRAT HMGCL MORF4L2 NEK11 CFH PML KRAS ERF FYN PTS APP NLK PMC2215060__F1A WE GATHER TOGETHER: INSULATORS AND GENOME ORGANIZATION CTCF IGF2 PMC8084285__F2 Promising role of defensins peptides as therapeutics to combat against viral infection INA SHE ACE2 PMC5278199__F1 Human EGF signaling pathway (reprinted from Biocarta ) STAT3 EGF SOST RAF1 GRB2 SHE PMC5993136__F1 Regulation of lipid metabolism in cancer cells ACLY DGAT1 CD36 FASN MTOR ABCA1 ACSS2 ACAT1 TG HMGCR DGAT2 LDLR SLC25A1 PMC3786223__F2 The potential role of miRNAs in the attenuated myogenic process in the elderly IGF1 SMAD2 CDC34 PMC11885449__F10 Mito-nuclear carbon metabolism in Toxoplasma FH APC MAL HEL-S-26 CIT PMC4177046__F1 Aberrant Regulation and Function of MicroRNAs in Cancer DGCR8 AGO2 DROSHA PMC4631599__F9 Intracellular Networks of the PI3K/AKT and MAPK Pathways for Regulating Toxoplasma gondii-Induced IL-23 and IL-12 Production in Human THP-1 Cells PI3 TLR4 PMC4057758__F6 Graphical representation of two of the top score networks identified by Ingenuity Pathway Analysis (IPA) MAX NRG1 ATR SIN3A PCNA BRCA1 DHFR SMAD4 ATM MDM2 SUV39H1 PMC3696504__F1 Relationship between metabolism and the autophagy machinery during the innate immune response IFNG ATG10 IL10 ATG3 ATG12 IL13 UVRAG IL18 IL4 HIF1A IL6 ATG5 PMC2196458__F7 Fas-signaling pathways in relation to the cytoskeletal networks, the Golgi-sorting compartment, and the surface membrane EGF FAS EGFR GC FADD PMC4262781__F1 Aberrant miRNA expression in liver cancer promotes cell-cycle progression CDC2 RB1 CDK6 PCNA SMAD2 SMAD4 CDK2 MDM2 MYC CDC25B CDK4 PMC12072370__F4 Knockout of StNADC has devastating effects on NAD synthesis and activates plant senescence and tuberization pathways ENPP3 NUDT15 SDHA HEL-S-8a SDHB NAXE NADK NAMPT SIRT2 PMC116060__F6 Proposed signal transduction pathways involved in PKC-mediated SRE activation ARHA RAC1 PMC4262781__F2 Aberrant miRNA expression in liver cancer affects the functionality of apoptosis pathways CDC2 RFWD2 BAX CASP9 ATR FAS CASP8 PCNA MCL1 PTEN MYC TSC2 CCNG1 CDK6 CASP3 CDK2 BCL2 ATM MDM2 APAF1 CDK4 PMC8222170__F7 KEGG pathology and disease analysis BAX COMP BAD APP PMC3178285__F5 Proposed signaling of TNFA− and leptin-induced EL upregulation in primary placental ECs MADD TRADD LEPR LIPG TRAF2 PMC11848126__F2 MTOR signalling pathway, highlighting mTORC1 and interactions that regulate canonical initiation MAF1 ULK1 IGBP1 LARP1 PTEN MTOR NCBP1 RHEB EEF2K PDPK1 CRY2 EEF2 ATF4 EEF1A1 PMC6938856__F10 Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer through the Blockade of the PI3K/Akt Axis MTOR CCND1 CTNNB1 PMC11848126__F4 CK2 signalling pathway, highlighting interactions that regulate canonical initiation EIF4B TGFB1 EIF3S2 NCK1 PER2 LARP1 PTEN TGFBR2 EIF4G1 EIF3G EIF3J EIF3F PDPK1 CRY2 ATF4 EIF4A1 ELF5 PMC3030971__F1 Key proteins and pathways in the replication stress response network RAD52 TOPBP1 ATR RAD51 MRE11A H2AX RAD17 INO80 ATM BLM PMC10728939__F3 Signaling pathways regulated by BAMBI SMAD2 APC LRP5 CD14 SMAD4 LRP6 TCF4 TRAF6 TGFBR1 MYD88 BAMBI TLR4 VCAM1 PMC6523967__F1 Cyclin D1–CDK4/6–Rb pathway in breast cancer TSC2 CDK6 CDK2 MTOR CCND1 CDK4 CTNNB1 PMC6598324__F7 The potential mechanism of FOXP3-mediated regulation of cancer cell stemness FOXP3 HES1 NOTCH1 PMC10886574__F3 Sirtuins Affect Cancer Stem Cells via Epigenetic Regulation of Autophagy TET2 SIRT3 SIRT7 NLRP3 TET1 SIRT4 SOX2 MSC SIRT2 CXCR4 CTNNB1 SIRT6 PMC5851329__F4 Summary of Potential Eph/Ephrin Tumor Promoting Pathways STAT3 FYN ERBB2 PTEN RHO RAC1 CTNNB1 PMC10886574__F2 The SIRT1–c-Myc axis in the control of stem cells MAX USP22 TERT SIRT1 PMC2682019__F9 A link between glucose and insulin signaling in Beta-cells IGF1 FOXO1 GRB2 MTOR PMC8267928__F5 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction REG3G TNLG7A MGST1 EVI1 TAP1 SMPD2 NRG4 TFF1 STAT1 SPHK2 MGST2 HEL-S-171mP PDGFC SPIB CYBA NOS2 EDN3 LAMC2 SORD PLAUR TNS4 ENPP7 APOBEC2 TMEM171 TM4SF4 IGSF9 SUSD2 XRCC5 AADAC SASS6 YPEL2 RAPGEF1 MUC4 PLEK2 SETBP1 FUT4 CD36 MYADM GIP GUCA2A ABCA1 TGFBR2 CD37 MX2 HEL-S-7 RRM2 BIN1 CEMIP ME1 HTATIP2 XAF1 RIPK3 HEL-S-8a NR1C1 PDK4 PMC8267928__F6 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction SKIL MAVS PTGR1 EVI1 TAP1 DHX58 ABCA1 NRG4 SIRT3 ZBP1 CASP4 USP18 CRY2 SPIB PAX8 MX2 OAS2 OXCT1 CD209 NOS2 STAT2 SORD TNFSF13 PLAUR BATF2 CTH SP110 ME1 CXCL10 ACOT12 MBL2 NR1C1 ZC3H12A LY86 PPT1 RNF186 AQP1 PMC8267928__F7 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction LOC51064 MGST1 PCK1 ABCA1 MAPK6 SIRT3 GSTA4 MGST2 NQO1 PPARGC1A NOS2 GSTM2 WRN RRM2 RBBP8 GSTM4 XRCC5 GPX2 GSTA3 NR1C1 GSTM1 GSTM3 EPHX1 SUV39H1 HEL-S-64p PMC7538784__F1 Current mechanisms proposed for metformin in pathological pain RHEB IFNG TSC2 CAMKK2 IPMK PMC4854363__F3 Negative regulatory NLR functions during viral infection NLRP12 TBK1 NLRX1 MAVS NLRC3 IRAK1 TRAF3 TRAF6 PMC8267928__F3 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction SIM2 MAVS STAT2 SORD CD36 PLAUR CTH SP110 ABCA1 SKI RIPK3 AADAC C2 PPT1 USP18 CRY2 MX2 FES AQP1 PMC7016866__F8 Model for the activation of Notch2 signaling in renal tubular epithelial cells under high glucose conditions and the possible actions of LE or LE/GC-KO in suppressing the Notch2 signaling cascade MAML1 PMC8267878__F5 Current Understanding of IL-37 in Human Health and Disease CCL3 RUNX2 CCL20 RAC1 PMC12078438__F5 NI-ADSCs activating the Notch pathway to promote nerve regeneration by inducing and maintaining the reparative phenotype of Schwann cells GFAP HES1 NOTCH1 PMC6638267__F8 Working model for the role of peroxisomes in fungal infection PEF1 PEX7 PEX6 PEX5 PEX13 PMC10875036__F5 IAV NS1 and SARS-CoV-2 Nsp1 antagonism of innate immune responses MAVS STAT2 IRF9 IRF3 IRF7 MYD88 STAT1 TRIM25 TLR3 IFNAR2 IFNAR1 TLR7 ISG15 EIF2A JAK1 TYK2 PMC3751673__F3 Ingenuity pathway analysis of the top-ranked network CCL23 CCL22 CD1B CD200R1 CD1A KMO IL17RB CCR4 NFIL3 IL13RA2 CRLF2 PMC3508196__F1 TARGETING ONCOGENIC BRAF IN HUMAN CANCER NF1 EGFR KIT ERBB2 PTEN MTOR MYC FOS PMC6721815__F2 MAPK signalling in the context of wild type BRAF and mutant BRAFV600E USP28 NF1 BRAF NRAS GRB2 PMC6721815__F3 Adaptive response-mediated resistance to BRAF inhibitors in melanoma ERBB3 USP28 EGFR TFEB BRAF GRB2 SOX10 PMC4931622__F1 The Wnt/Beta-catenin signaling pathway in renal cell carcinoma (RCC) APC GSK3B IGFBP4 CCND1 WIF1 CTNNB1 VHL PMC7730698__F2 Role of CK1D/E in the Wnt signaling pathways ROR1 DKK1 ROR2 GSK3B LRP5 LRP6 RYK FOXP3 MYC CTNNB1 PMC10527795__F1 Wnt signaling pathway CDC42 APC ROR2 LRP5 LRP6 RHO RAC1 CTNNB1 PMC6160310__F1 Hepatitis E Virus life cycle ACTG1 IFNGR1 IRF9 EIF3A TSG101 IRF7 TUBB EIF4E IFNG STAT1 IFNAR2 EIF4A2 ISG15 EEF1A1 PMC7892472__F1 Key aspects of BAFF-R, TACI, and BCMA signaling within the context of CVID RELA RELB BCL2 TRAF3 TRAF2 PMC3873642__F1 A proposed model of the DNA-damage response pathway BRCA1 H2AX RNF8 ATM MDC1 PMC11204528__F8 Dicerandrol C Suppresses Proliferation and Induces Apoptosis of HepG2 and Hela Cancer Cells by Inhibiting Wnt/Beta-Catenin Signaling Pathway GSK3B LRP5 LRP6 LEF1 CTNNB1 PMC7462918__F3 Membrane trafficking of SGLT1/Sglt1 TGFB1 SGK1 RS1 PMC4384750__F9 Model of SOX2 feedback signaling pathway EGFR SOX2 BMF FOXO6 PMC9374328__F1 c-Met: A Promising Therapeutic Target in Bladder Cancer HGF C2 SMURF2 SRC CREB1 PMC12206656__F4 Copper is closely associated with various forms of PCD RIPK3 DLAT GSDMD PINK1 ZBP1 NLRP3 GPX4 FES MTOR PMC8072220__F8 Complex of distal appendage–associated kinases linked to human disease regulates ciliary trafficking and stability CEP164 PLEKHO1 CSNK2A1 SMO PMC3713213__F7 Signaling pathways showing mechanisms involved in the protective effects of cardiac-specific CYP2J2 transgenic mice subjected to diabetic stress ATR PDK4 CYP2J2 IRS1 PMC8066826__F2 Adiponectin and its receptors and schematic representation of adiponectin-induced signaling pathway APPL1 ADIPOR1 ADIPOR2 MTOR PMC9104939__F6 Recent Advancements in Antifibrotic Therapies for Regression of Liver Fibrosis TGFBR2 IGF1 TLR4 SMAD2 AKT3 TLR9 BCL2 IGF1R CTGF TGFBR1 PMC6952948__F5 The role of mTOR in glutamine metabolism and hexosamine biosynthesis GLS MYC PMC6952948__F6 The role of mTOR in the pentose phosphate pathway and nucleotide synthesis MTHFD2 HEL107 CAD RPIA OMP IMPDH2 HEL-S-70p MYC PMC7961658__F7 Possible mechanism of action of glycyrrhizin (GL) in colon cancer STAT3 HMGB1 SOX9 TLR4 IL6R MYD88 PMC9343382__F1 Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe? NRK NAPRT HEL-S-90n NAMPT PMC4386408__F5 The mechanism of the switch off in Shh canonical signaling during spinal cord development SHH SMO GLI3 PMC4994041__F7 The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis YAP1 CTNNB1 PMC4130654__F1 PI3K-PTEN-mTOR pathway RHEB TSC2 TSC1 SGK1 PTEN RHO PDK2 DEPTOR RAC1 PMC7566413__F2 Regulatory Function of CCR9+ Dendritic Cells in Inflammation and Autoimmunity CCL25 FOXP3 PMC10874556__F1 Mechanical cue-dependent scarring STAT3 RREB1 IL33 IL11 ZEB2 PMC3095361__F9 ROS, elicitor and hormone regulation of O3-induced CRKs TF DND1 PMC5581728__F2 Molecular actions of HDIs in sarcoma FUS BAX RARA PTEN MDM2 FADD PMC3116122__F1 PI3K pathway activates different processes that regulate proliferation, apoptosis and migration BAD EGFR PTEN RHO MDM2 MTOR PMC3372068__F1 Coagulation and complement cascades TF HEL-S-62p C2 CS PMC7013859__F2 LPS recognition by toll-like receptor 4 (TLR4) TLR4 CD14 IRF3 LBP MYD88 PMC7216071__F8 Activation mechanism of miR-223 negative regulation of the TLR4/MyD88-NFKB signaling pathway NLRP3 IL1B MYD88 PMC517537__F7 Signaling kinases involved in regulation of TNFA, IL-10, and IL-6 in Kupffer cells LTA SRC PMC3428770__F2 Signalling events activating PKB/Akt and cellular functions regulated by PKB/Akt WNK1 SYK TBK1 BAD RAF1 HEL-S-28 PTEN EIF4E TSC2 TSC1 CDC37 MDM2 JAK1 GAB2 TBC1D4 HTT PMC6423427__F1 Overview of UPR signaling pathway ATF4 EIF2A XBP1 PMC8036623__F2 Proteolysis on the VEGF pathway STAT1 PLG MMP2 MMP9 PMC3587611__F8 Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial Germ Cells in the Mouse Embryo PGC CTDNEP1 DKK1 LRP5 WNT3 CTNNB1 PMC9557158__F9 MiR-21 and let-7 cooperation in the regulation of lung cancer LIN28B LIN28A PLAG1 PMC3759196__F9 Aberrant Signaling Pathways in Glioma STAT3 SMAD1 DKFZp781O1323 TNFAIP3 SMAD4 OLIG2 IL6 NOTCH2 TRRAP BMI1 PTCH1 SHH SMO NOTCH3 NOTCH1 GLI3 PMC4177022__F6 Proposed mechanism of testicular apoptotic response to x-ray exposure CASP9 FAS CASP8 AVEN APAF1 CASP10 BIRC3 PMC3196283__F1 BER pathways BER is initiated by a damage specific DNA glycosylase and APE1 that excise the damaged base and incise the arising abasic site, respectively generating a DNA single strand break with a 5'-sugar phosphate FEN1 PCNA PMC3759196__F6 RTK/PI3K/Akt signaling TSC2 TSC1 PTEN PMC3759196__F7 P53 pathway and retinoblastoma (RB) tumor suppressor protein signaling are shown RB1 MDM4 ATM MDM2 CCND1 CDK4 PMC3650616__F9 MEK inhibition increases lapatinib sensitivity via modulation of FOXM1 FOXM1 EGFR MTOR PMC12072112__F5 Insulin resistance, neuroinflammation, and tau pathology in Alzheimer’s disease IDE TLR4 GSK3B MTOR PMC12072112__F1 Insulin signaling pathway regulating glucose uptake and storage MTOR IRS1 PMC12072112__F2 Interaction between insulin signaling, inflammation, and oxidative stress in cellular metabolism TG GSK3B GRB2 MTOR IRS1 PMC10757641__F1 G protein-coupled receptors and obesity GLP1R NTS GHSR PYY POMC MC4R GIP ARC GCGR AgRP GIPR PMC11983301__F2 Podocytes, renal tubular epithelial cells, and glomerular mesangial cells in DKD USP25 TRIM13 PINK1 APC FASN TRAF6 TRIM63 VHL FBXW7 SMURF1 RFFL USP22 GATA4 TRIM29 SIRT1 CYLD PMC12228841__F5 TLR2 and TLR4 signaling pathways and their interplay TLR1 TLR4 TAB3 IRAK1 TRAF6 IRAK4 MYD88 PMC4779598__F5 A proposed model illustrating how SOX4 interacts with PI3K-AKT, Wnt-Beta-catenin, and AR signaling pathways, and how the PI3K-AKT-mTOR pathway regulates the expression of SOX4 in prostate cancer progression EGF EGFR GSK3B PTEN SOX4 CTNNB1 PMC4264417__F2 Notch receptor and pathway EGF MAML1 NOTCH2 NOTCH3 NOTCH1 PMC4264417__F3 Notch–EGFR crosstalk in TNBC EGF EGFR NOTCH1 PMC4264417__F4 Notch–HER2 crosstalk in HER2+ BC (A) EGF HRG PMC8077955__F2 Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease IGF1 IL16 TLR4 IL6 TNF MERTK PMC4264417__F1 HER receptor and pathway: (A) there are four members of the HER family of RTKs: EGFR/HER1, HER2, 3, and 4 RHEB EGF EED EGFR PTEN PDK2 DEPTOR PMC5930388__F5 PI3K/AKT/mTOR pathway TSC2 TSC1 PTEN PMC2330246__F1 Overview of NAD biosynthesis and salvage pathways and a link with other metabolic pathways via ADP-ribose HEL107 RPE PMC4856023__F3 The blockade of immune checkpoints in cancer immunotherapy CTLA4 PMC4183535__F4 Maternal Obesity and Tobacco Use Modify the Impact of Genetic Variants on the Occurrence of Conotruncal Heart Defects GSTA3 GSTM2 RFC1 GSTA4 TCN2 GCLC DNMT3L BHMT2 AHCYL2 HEL-S-61p MTHFS MGMT PMC11049885__F2 Network comprised of the IRs affecting ecdysone synthesis MRPL44 TH FDX2 ITM2C UPF2 PPP1CC EBP SC5D PIK3R1 DHCR24 AKR1B1 DAO SHANK3 HBG2 MED18 HBG1 PIGN GFRA2 SOAT1 PIGK ALG14 HBB HTT CDK4 CYP51A1 CSNK1D SREBF2 SSNA1 DPAGT1 HAUS1 ALDH3A2 VKORC1 MYOC UBA3 ONECUT1 ENO3 TRFP NAB2 PPP2R1B RPN1 MAPK7 TP63 FAM114A1 MRPL32 ALDH3B1 NINL CEP78 ZFC3H1 PMC11049885__F3 Network comprised of the IRs that compete with ecdysone synthesis MRPL44 TH FDX2 ITM2C UPF2 PPP1CC EBP PIK3R1 DHCR24 AKR1B1 HBG2 MED18 HBG1 PIGN NQO1 SOAT1 AKT1S1 ALG14 HBB CDK4 CYP51A1 UBIAD1 CSNK1D SREBF2 SSNA1 DPAGT1 HAUS1 ALDH3A2 MYOC UBA3 ONECUT1 PNPLA3 ENO3 TRFP NAB2 PPP2R1B RPN1 MAPK7 TP63 FAM114A1 MRPL32 ALDH3B1 NINL HAUS6 CEP78 ZFC3H1 PMC9446423__F2 Endocrine therapy resistance: what we know and future directions TSC2 TSC1 SP1 PMC5222515__F5 Methodology for Cancer Therapeutics by Systems Pharmacology-Based Analysis: A Case Study on Breast Cancer-Related Traditional Chinese Medicines NOS2 CHRM4 PIM1 CHRM2 PGR CHRM1 EGFR RXRA CHRM3 KDR NR3C1 PMC2796982__F3 Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway CDC42 FZD3 APC WNT1 RHO DAAM1 CTNNB1 PMC11049885__F6 Key IRs significantly affecting ecdysone synthesis FDX2 EBP SC5D SREBF2 PMC7404026__F1 Canonical and non-canonical Nuclear factor kappa B (NFKB) signaling pathways CD40 ZAP70 SYK LTA TRADD RELB TRAF6 MYD88 LTB BTK BCL10 BCR RELA REL TRAF2 LCK PMC6005692__F11 HIV-1 gp120 up-regulates BDNF expression in BV2 cells via Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 TEF PMC8338882__F2 HPV immune modulation of the tumor microenvironment CD80 HLA-E FOXP3 PMC7290828__F1 Mitochondrial Protein Quality Control System (MPQC) HTRA2 PINK1 CLPP OMA1 CLPX MIP PMC3732602__F1 TGFB signaling TGFBR2 RAF1 RHO PMC8621451__F5A Positive Salt Tolerance Modulation via Vermicompost Regulation of SOS1 Gene Expression and Antioxidant Homeostasis in Vicia faba Plant SOS1 SOS2 HEL-S-11 PMC3732602__F5 TGFB processing and uPA-uPAR-dependent activation PLG FURIN PMC10140933__F12 Pathways of protein synthesis and transport activated by CsRALF34 overexpression (based on the KEGG signal pathway database) GCN1 VAMP7 PMC3240715__F3 Molecular mechanisms of FGFR3 signaling in cartilage SOCS1 STAT3 STAT1 FRS2 SOS1 LIF IHH FGFR3 SOCS3 IL6 CNP GRB2 PMC8100490__F7 Zearalenone exposure affects the Wnt/Beta-catenin signaling pathway and related genes of porcine endometrial epithelial cells in vitro APC USP1 GSK3B LRP5 SMAD4 LRP6 CCND1 XRCC3 CTNNB1 PMC4409267__F1 Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation ACAT1 FAS ACAT2 PDC PC PMC2999931__F2 Postsqualene cholesterol synthetic pathway EBP SC5D DHCR24 DHCR7 HSD17B7 LBR PMC7248321__F5 Multiple signaling networks are regulated by hsa-miR-205-5p based on ingenuity pathway analysis (IPA) ABI2 PHF20 KIF13B RAN SLAIN2 NOX5 CSF1 MDIG HAUS8 PHETA2 NCAPG CDC42BPA SPIRE1 PLXNB1 MYC CDC42EP3 NEK6 MID1 BMF ACVRL1 ATG5 SERINC3 FLNB FIS1 MIA3 MARK4 AREG KITLG FERMT2 CHCHD3 MKI67 PDK4 GSTM1 HYOU1 DDX11 POLDIP3 RELA INPPL1 ELF3 PMC7149230__F5 Synchronization of central carbon enzyme and metabolite abundance with cell cycle phases ACO2 ENO2 HEL-S-49 MAL HEL-S-32 CIT PMC6760157__F6 Cystathionine Beta-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter EPOR EPO ALAS2 FECH PMC3784205__F6 Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans TFAM PNPLA2 PDK2 CPT2 PMC2729268__F2 Map of protein interactivity (binding, regulation, modification) between genes revealed to be significantly associated with bladder cancer in urothelial cell samples GNB1 F11R ATF3 LRP8 TFRC HHIP LEPR APOE ERBB2 BMP7 AMFR TGFBR1 PMC5661256__F7 Schematic diagram of a signalling pathway related to anti‐apoptotic or anti‐inflammatory effects of polydatin on LTA‐induced injury CASP9 LTA CASP3 PMC4625495__F1 Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury IL6 ARHA PMC4389564__F1 CD44 acts as a co-receptor for several cell surface receptors including RTKs, G-protein coupled receptors, and LRP6 CD44 CXCL1 LRP6 CXCR4 CTNNB1 PMC8942208__F3 Differentially expressed components of four of interesting pathways involved in immune response and drug metabolism in F. gigantica-infected hLNs and pBLs AZU1 CD1E CCR3 GP5 CXCL3 MPO NCR1 INHBB GSTA4 IL18 MAPK12 CCL17 IL17F IL13 LIF IL4 PTGS2 PLA2G4F MMP9 IL1A IL6 CXCL6 TNF CXCL10 GSTA3 ADH6 FOSL1 FGA ALDH3B1 IL12B LBP IL23A PMC4255043__F1 Induction of nuclear factor-activated T cells c1 (NFATc1) in osteoclasts TREM2 SIRPB1 GSK3B OSCAR MAFB NFATC1 HEL-S-11 IRF8 TRAF6 PMC10931359__F3 S1PR signaling pathways in liver regeneration and HCC progression S1PR1 S1PR3 S1PR2 RHO PMC7486245__F1 Components of the TgfB signaling pathway that have been implicated in cardiomyocyte proliferation SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC7669638__F2 Molecular Regulation of Cdk5 activity NGF EGR1 CDK5 FYN GDNF BDNF PMC4104512__F4 Functional zonation of the rat adrenal cortex: the development and maintenance CYP11B2 CYP11A1 ZFR PMC6902440__F4 Interactions of TGFB pathways, WNT, Smad and the Hippo pathway in fibrosis LATS1 LATS2 PTEN PMC6902440__F2 TGFB1 effects on the balance between the canonical WNT/Beta-catenin pathway and PPARG DKK1 SMAD2 APC LRP5 SMAD4 LRP6 CTNNB1 PMC6910186__F8 Roles of miR-21 and the PDCD4/c-Jun signalling pathway in renal cell carcinoma MMP2 MMP9 VEGFA PMC3303581__F1 Myostatin signals through the ActRIIB-ALK4/5 heterodimer activate Smad2/3 with blocking of MyoD transactivation in an autoregulatory feedback loop RHEB IGF1 SMAD2 MTOR PMC5363987__F8 CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy PRLR EREG ERBB4 PRL CUZD1 PMC6487484__F1 Mechanisms Linking Mechanotransduction and Cell Metabolism ARHA CTNNB1 PMC10686715__F2 Exosomes from different MSCs mediate PCD in myocardial cells after myocardial infarction BAX NLRP3 STEAP3 MSC PTEN TRAF3 MTOR ATG5 PMC6487484__F2 Mechanisms Linking Mechanotransduction and Cell Metabolism ARHA CTNNB1 PMC4367964__F5 Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta HMGB1 PYCARD RPS6KB2 CIAO1 SNRNP200 ITGAM DDB1 SNAI1 NLRP3 TICAM1 CASP4 TLR4 IL18 MMP3 MUC1 IL1B PMC10686715__F4 Angiogenic effect of exosomes released by different MSCs after MI EFNA3 TH HGF MSC PRSS23 PMC4229635__F6 Shed Sdc-1 induces the activation of EGFR and downstream signalling pathways via sHB-EGF MMP7 HBEGF EGFR MMP9 PMC10686715__F5 Exosomes secreted by different sources of MSCs regulate the inflammatory microenvironment after myocardial infarction MSC FES EZH2 BCL2L11 BCL6 PMC8599300__F4 Mechanistic Target of Rapamycin Complex 2 Regulation of the Primary Human Trophoblast Cell Transcriptome CRP SOCS1 STAT3 MAPKAPK2 CD14 A2M SOCS3 TNF TRAF2 LBP PMC5786332__F6 HIV replication in monocyte derived macrophages (MDM) by steroid hormones IL15 CXCL9 IFNA13 CCL3 IFNA2 TNF CXCL10 CXCL11 IKBKB IFNAR1 IFNB1 IL12B IL1B PMC4196580__F6 Toll-like receptor signaling pathway showing the annotated and non-annotated proteins CD40 TIRAP CTSK TLR9 CD14 CPO TRAF6 IRAK4 RAC1 TLR3 LBP CD6 FADD PMC4196580__F7 B cell receptor signaling pathway showing the annotated and non-annotated proteins SYK BCL10 BCR CD72 GC CD22 BLNK CD19 LYN PMC4196580__F8 T cell receptor signaling pathway showing the annotated and non-annotated proteins CD48 CBL FYN BCL10 LAT ITK GRB2 LCK CDK4 PMC4196580__F9 Chemokine signaling pathway showing the annotated and non-annotated proteins CRK ELMO1 RHOD ITK SHE REL DOCK2 PMC8755678__F3 Endothelium function by fatty acids KLF2 FOXO1 DLL4 VEGFA MYC CPT1A NOTCH1 PMC3489747__F2 TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis TBK1 COMP IRF3 FADD PMC7473858__F8 Pathway modeling for genome signaling and metabolic reconstruction revealed the pathological mechanism of oral cancer using KEGG and Wiki pathway databases BAX PTEN PMC7028849__F8 Schematic illustration on possible roles of aminooxyacetic acid (AOAA) on macrophage metabolism and polarization CD36 PFKL TNF PMC7281956__F10 The ROS/PARP/TRPM2 signaling pathway that mediates SiNPs-induced pulmonary inflammation in mice TRPM2 PARG CXCL1 SQSTM1 CXCL8 PMC9621617__F4 Alterations in bone fracture healing associated with TNFRSF signaling pathways MSC NFATC1 RUNX2 FADD PMC2799380__F6 Connective tissue associated signalling network common to various cardiac hypertrophy animal models and human cardiac disease SLC7A1 COL1A2 TIMP1 ASPN EGFR SMAD2 SMAD4 COL14A1 ATP1A1 CS COL3A1 COL1A1 SERPINE2 IGFBP5 OSMR KLF9 SULF1 APP FBLN2 PMC11053956__F6 JAK/STAT signaling pathway mapper TRADD OSM H2AX MLKL IL33 TNF LOX PIG59 ZBP1 NLRP3 TLR3 TLR4 FES USP21 CYLD FADD PMC7428229__F7 DEGs mapped to the cysteine and methionine metabolism pathway in shoots SMS APIP ADI1 MRI1 PMC8176883__F3 Proteomics-Based Insights Into the SARS-CoV-2–Mediated COVID-19 Pandemic: A Review of the First Year of Research GIGYF2 MYH9 RTCA PMC7300268__F4 YAP/TAZ regulation by lipid metabolism and YAP/TAZ-targets for Lipid metabolism LPA FAS HMGCR ARHA CTNNB1 PMC6161735__F1 Nrf2/Keap1 signaling pathway in homeostatisis and stress KEAP1 MAF PMC3251842__F2 TGFB response pathway TF SMAD2 SMAD4 PMC5817727__F4 Regulation of PTEN, a major regulator of the PI3K/AKT signalling pathway EGR1 PTEN ATF2 PMC9412181__F1 Overexpression of enzymes in glycolysis and energy metabolic pathways to enhance coenzyme Q10 production in Rhodobacter sphaeroides VK-2-3 ACLY SDHA DLAT OGDH HEL-S-162eP GCK ADPGK MVK PMC5831902__F3 The calcineurin/NFAT signaling pathway and the miRNAs involved in feedback loops to modulate the pathway activities AKAP5 MAP3K7IP1 DYRK1A ORAI1 LRRK2 STIM1 HOMER2 PMC6862668__F1 Signaling pathways and therapeutic targets BMP10 ENG PTEN VEGFA KRAS PMC5348387__F6 Oncolytic vaccinia virus combined with radiotherapy induces apoptotic cell death in sarcoma cells by down-regulating the inhibitors of apoptosis BAX BAD DIABLO PMC5734142__F1 Reduced Retinoblastoma Protein Expression Is Associated with Decreased Patient Survival in Medullary Thyroid Cancer CDC2 CDK6 CDK2 RET CDK4 PMC4009444__F2 Intracellular signaling pathways for hepcidin expression BMP6 SMAD1 DKFZp781O1323 HFE IL6 HFE2 PMC4397969__F1 (De-) Oiling Inflammasomes MAP3K7IP1 NLRP3 ARRB2 IL1B MYD88 PMC8226720__F1 An Overview on Diffuse Large B-Cell Lymphoma Models: Towards a Functional Genomics Approach CD40 TET2 TNFRSF14 DTX1 TNFAIP3 SGK1 CD27 TNLG8A EZH2 IL6 IRF8 BTG1 BCR MLL2 EP300 CCND1 BCL6 PMC8848207__F1 Role and mechanism of action of LAPTM4B in EGFR-mediated autophagy STAT3 TSC1 EGFR UVRAG EIF2A ATG5 PMC8848207__F2 Role and mechanism of action of LAPTM4B in EGFR-mediated autophagy STAT3 ATG3 LAPTM4B EGFR MTOR PMC9177660__F2 NcRNAs implicated in regulation of ferroptosis GPX4 ASCL4 SLC7A11 PMC8879474__F5 Tissue Transglutaminase but Not Microbial Transglutaminase Is Inhibited by Exogenous Oxidative Substances in Celiac Disease IFNG APC PMC9685814__F2 From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders ACHE BCHE BDNF PMC6597757__F2 Illustration depicting primary signalling mechanisms of different neuronal and astrocytic proteins encoded by genes implicated in ID/ASDs SHANK3 MTOR PMC8558397__F1 Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges EGFR APC CTNNB1 PMC4329815__F3 Signaling pathways implicated in hyperstimulation of macropinocytosis and vacuolization of macropinosome-derived compartments NGF PAK1 ARF6 PMC8467255__F4 Biological Significance of the Protein Changes Occurring in the Cerebrospinal Fluid of Alzheimer’s Disease Patients: Getting Clues from Proteomic Studies APOC2 ABCG1 APOA4 ABCG5 CD36 LDLR ABCG4 ABCA1 PMC7760556__F1 Possible pathways for immunogenic activation in response to autologous iPSCs-whole cell vaccines CD40 HEL-S-92n CD80 tmp_locus_29 PMC4065631__F2 Ligand bias prevents class equality among beta-blockers ARG1 ARG2 PMC8432812__F5 Proteogenomic analysis of pancreatic cancer subtypes SPEN RPTOR DKK4 STK11 TLE3 COPE APC AKT3 NRARP PTEN MTOR RHEB DKK3 TEC TSC2 RICTOR TSC1 RNF43 HEL-S-11 EP300 PMC5825871__F9 Role of Gpr161 in forelimb initiation, limb patterning and skeletal morphogenesis GPR161 PTCH1 SHH IHH TBX5 FGF10 RUNX2 GLI3 PMC10525532__F4 Thioredoxin/Glutaredoxin Systems and Gut Microbiota in NAFLD: Interplay, Mechanism, and Therapeutical Potential NLRP3 TXNIP IL1B PMC3879708__F2 Upstream nutrient signaling to mTORC1 and AMPK RHEB TSC2 TSC1 BNIP3 PMC8507803__F2 Good Cholesterol Gone Bad? HDL and COVID-19 TG ABCG1 PON1 APOB ABCA1 PMC3966329__F1 Regulation of autophagy by ARV TFEB PTEN EIF2A PMC8009859__F1 Illustration of proposed MB related proteins/pathways described in this review. (i) Conventional MB-related signaling pathways SP1 SUFU APC GSK3B WEE1 SMO PDE4D MTOR SRC CTNNB1 PMC8474995__F1 Is there a place for cellular therapy in depression? CRP NLRP3 GC PMC5657612__F10 The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease AQP4 CD36 PICALM PMC8172449__F1 NAD metabolome and metabolic pathways NRK CYP2E1 HEL-S-90n NAXE NMNAT1 KYNU KMO NAMPT AFMID NAXD NNMT SARM1 HEL-S-162eP HAAO TPO PMC5851940__F5 Highlighted genes to represent a single pathway CDC42 TEC ARHH ITGAM ITGB1 ITGA4 ARHA CXCR4 RAC1 PMC5851940__F1 Biological pathway of Leukocyte Transendothelial Migration () TEC JAM2 ARHH THY1 TOB2 RAE1 ARHA JAM3 RAC1 CD99 PMC7949067__F3 Relevant pathways of the unfolded protein response (UPR) BAX BAD EIF2A XBP1 PMC7369379__F7 C-P-T network of top 20 pathway BAX JUN NR1C1 PLAT RXRA RELA PRKCA CHUK CCL2 PMC5432641__F2 Nucleotide excision repair and the ATR-CHK1-mediated DNA damage checkpoint XPA TOPBP1 ATR ATRIP TIMELESS XPC PMC10965438__F1 Nanomaterials modulating TAMs for the treatment of GC STAT3 CD80 NPS CD163 DUSP2 PMC5980186__F5 Proposed model describing the regulatory pathway between Smad7 and hepcidin expression in hepatocytes BAMBI BMP6 SMAD1 DKFZp781O1323 SMAD6 SMAD4 HFE PMC10965438__F6 Nanomaterials modulating TAM polarization for the treatment of HCC via the STAT signaling pathway STAT3 STAT1 CD80 CD163 PMC6097550__F1 NRAS mutant melanoma: an overview for the clinician for melanoma management CDK6 NRAS CDK4 PMC10965438__F7 Nanomaterials modulating TAMs polarization for the treatment of HCC via the NFKB signaling pathway STAT1 CD80 NPS CGAS TLR5 TLR7 PMC5429649__F11 The mechanism of Salvia fruticosa-induced relaxation of rat isolated aorta COX1 COX2 C2 PMC6154840__F1 PKCι drives both common and lineage-specific oncogenic pathways in lung cancer MMP10 PAK1 SUFU ECT2 PTCH1 SOX2 SHH SMO KRAS RAC1 ELF3 PMC5976231__F5 Vascular wall resident Sca-1+ progenitor cell migration in response to chemokines and lipoproteins CDC42 STAT3 CXCL1 CCR2 IL8RB MMP9 CCL2 RAC1 PMC10846380__F6 CK1A degradation by FPFT-2216 and subsequent p53 pathway activation and CBM complex/NFKB pathway inhibition DDB1 CUL4A BCL10 CARD11 MDM2 CRBN PMC11786022__F7 Mechanism of TGFB activates cancer metastasis potential by inducing metabolic reprogramming and bioenergetic adaptation CDC2 CDK6 CDK2 CDK4 PMC3572906__F3 Microbial Cell Components Induced Tolerance to Flagellin-Stimulated Inflammation through Toll-Like Receptor Pathways in Intestinal Epithelial Cells HEL-S-31 ECSIT JUN TIRAP CD14 IRF3 IRAK2 CXCL10 IRAK4 MYD88 BTK MAP3K1 TRAF2 FADD PMC12135143__S1 Biosynthetic pathway of IMP (Adapted with permission PURB PMC8192774__F3 Differential methylation of G-protein coupled receptor signaling genes in gastrointestinal neuroendocrine tumors VNN1 SERPINF2 KRT71 CACNA2D2 RXFP4 ACTA1 COL3A1 VNN2 DEFB129 DEFB128 GIMAP4 APOBEC4 TAAR9 TAAR6 PPBP DEFB136 TAAR5 F2 KCNAB1 DEFB134 TAAR2 KRT73 CEACAM3 PECR URI1 GPT GNAI1 PNOC CEACAM1 KPG_011 KCNV2 POLR3G GABRB3 POLR2F TRHR SST KRT6B PVALB SIRPA GATA4 PMC12016470__F8 Sildenafil promotes osteogenic differentiation of hMSCs and suppresses bone loss by affecting TGFB signaling SMAD2 SMAD4 PMC5322168__F5 Induction of IL-21 in Peripheral T Follicular Helper cells is Indicator of Influenza Vaccine Response in Previously Vaccinated HIV-Infected Pediatric Cohort CDH2 STAT3 ZAP70 SELL ID2 IL21R DUSP4 NFATC1 CXCL10 RORA RUNX3 ID3 IL-21 IFNG ICOS CCR7 CXCR5 CAMK4 STAT4 IL6ST FOXP3 CXCR4 PMC9264955__F6 Prognostic and Predictive Role of Body Composition in Metastatic Neuroendocrine Tumor Patients Treated with Everolimus: A Real-World Data Analysis RHEB MLST8 TSC2 GRB10 TSC1 DEPTOR PMC4740345__F3 Sirolimus and CNI impact on insulin signaling pathway YY1 IRS1 PMC5322168__F4 Induction of IL-21 in Peripheral T Follicular Helper cells is Indicator of Influenza Vaccine Response in Previously Vaccinated HIV-Infected Pediatric Cohort IL15 TRIM5 CD2 SELL ID2 CD69 IL4 IL2RA IL21R IL7R RUNX3 IL-21 IFNG ICOS STAT1 PIK3C2B CD74 BCR CCR7 STAT4 IL6ST BCL6 PMC3648498__F3 Alzheimer’s disease pathway from the KEGG database LPL IDE CASP9 BAD AGER CASP12 CASP3 SNCA APP TNF FADD PMC7305909__F1 Virus-based and host-based targets against the coronavirus replication cycle TMPRSS2 HEL-S-69p DPP4 FURIN ACE2 PMC12102949__F2 Illustrates Various Molecular Mechanisms Facilitating the Formation and Survival of DTPs under Targeted Therapy and Immunotherapy SMARCC1 ARID1A OGT BRD4 GPX4 SOX2 EZH2 SETDB1 MTOR MED1 FGF2 CTNNB1 FOXM1 ASCL1 NPC1L1 APOB ChAT GRB2 POLE APOBEC3B SMARCA4 PMC12102949__F3 Multiple Cross-linking Mechanisms among Tumor Cells or/and the Surrounding Environment Sustain the Formation and Persistence of DTPs under Targeted Therapy and Immunotherapy TF TNLG5A CXCL12 HGF CCL11 CD27 TNLG8A CXCL1 MTOR CTNNB1 IFNG FGF7 FGFR4 OIT3 PMC10932085__F1 TRPs modulate inflammation in immune cells STAT3 TRPM7 TRPC1 TRPV1 MTOR TRAF6 STAT1 TRPM2 NLRP3 TRPM5 FOXP3 TRPC6 TRPC3 PMC10932085__F2 TRPs modulate anti-inflammation in immune cells TRPV1 TRPC5 TRPM8 PMC6824679__F2 Synthesis of phosphatidylinositol and acyl chain remodelling TAMM41 LPA TG PGP MBOAT7 PC PMC5103281__F2 Mechanistic cycle for silyl-mediated cross-coupling ALK SET PMC4295872__F8 Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation CASP9 BAD CASP8 EGFR CASP3 ERBB2 EPSTI1 PSMC3IP FADD PMC4999690__F1 GM-CSF and IL-6 signaling STAT3 MMP9 JAK1 CDK9 PMC6356072__F4 Protein-protein interaction networks among differentially expressed proteins PDPN SLC25A5 SYNPO APPL1 DNCL1 NMT1 ARPC5 GGCX CYCS ACADM PEX3 LAMB1 MAOA ALB TRAPPC4 NID1 BAG5 CAMKK2 QK3 NF1 EIF3F MFN2 OPA1 ACADS IFT74 XXYLT1 ACTR2 COL18A1 SUCLG2 FKBP2 SNRPA1 VDAC3 AGPAT5 SPARCL1 YLPM1 LMO7 ABAT TPR SNAPIN DPP4 FARSB COXFA4L2 UBXN6 CMC4 FH PTN ACO2 UBE2M SLC22A2 GMDS BANF1 DLAT PTPRS ACTN4 EIF3J RHOB CPT1A RPL26 PS1TP5BP1 NDUFB6 LETM1 SLC6A13 NDUFV2 DNAJC5 CDIPT GNAZ SLC25A4 CHCHD6 HSPA2 NDUFS6 COL4A1 AGL MRPL47 AASS HEL-S-2 LIMA1 FZD2 HEXIM1 CLYBL SLC2A3 SLC19A1 HEL-S-78p HRAS ACAN AQR PPP1R18 EIF3E CAPZB FGA LAMA4 AK4 TES NFU1 SSBP1 ADAR TRIAP1 RAB31 ABCB7 ETHE1 NAAA ETFA RPL17 FYCO1 APOH HCFC1 UBAP2L DYNC1H1 PFKM RAPH1 NRGN GBP3 NUCKS1 ABCE1 ABHD11 PDIA4 A1BG CPNE3 EARS2 SHISA7 BTF3L4 HSPA4L PITRM1 FAM136A AIF1L C1QTNF5 SBSPON FN3KRP MTIF3 MIEN1 IARS2 SLC35A4 NDUFB10 IRGQ KDM1A CISD1 FAM98B ALG6 CCT8 SMU1 CSPG4 PMC5288241__F2 Prostate cancer and the unfolded protein response ATF4 EIF2A TRAF2 PMC12200665__F9 TPA-induced activation of a PKCD/RIPK4/IRF6 signaling pathway inducing lytic EBV reactivation and epithelial cell differentiation in EBV-infected NOKs KLF4 IRF6 dik PMC4066235__F4 microRNAs in Cancer Cell Response to Ionizing Radiation ATR H2AX CDK2 ATM MDM2 CDK4 PMC4066235__F5 microRNAs in Cancer Cell Response to Ionizing Radiation CDC2 ATR H2AX WEE1 ATM MDM2 CCNB1 PMC4066235__F7 microRNAs in Cancer Cell Response to Ionizing Radiation BAX CASP9 CASP8 MCL1 FADD PMC2721360__F2 Colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition ITGB4 APC SMAD4 FHL2 PRNP HIF1A MYC CTNNB1 RARA MAP1A HEL-S-130P CTSO AXIN1 NFE2L2 WIF1 PMC3488108__F1 Immune-Neuroendocrine Integration at the Adrenal Gland: Cytokine Control of the Adrenomedullary Transcriptome IFNG STAT3 STAT2 PMC3014093__F3 Upper panel LIG1 WRN PMC6991964__F8 EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria LTA EPHA2 CCL2 TNF PMC12049823__F1 Genetic regulation of SPP1 regulated by TFs and the signaling pathway in disease CD44 STAT3 MIF RUNX2 CTNNB1 PMC6288187__F1 Vasorin 3D structure: Cartoon representation of the structure model of Vasn predicted by RaptorX (http://raptorx.uchicago.edu/) ADAM17 SMAD2 SMAD4 NUMB ADAM10 VASN PMC5951947__F4 An illustration of the PI3K mutant, ER+ breast cancer network BAD CDK6 FOXO3A MCL1 CDK2 BCL2 PTEN IGF1R MYC CDK4 PMC7187888__F6 Danqi Pill (DQP) targeted on HIF-1A/PGC-1A signaling pathway and finally elevated cardiac energy metabolism in the failing heart UCP2 TFAM NR1C1 PDK4 RXRA NRF1 VHL PMC7189569__F4 TNF signalling pathway MADD TRADD TRAF3 PTGS2 TNF APAF1 TRAF2 FADD PMC10418884__F10 Regulatory pathway of GR GC SRC PMC7390836__F4 DSGs That Are Driver Genes of the CRC Pathway(A) Mapping of DSGs in the CRC pathway from KEGG EGF CASP9 MSH6 BAD MSH2 MSH3 SOS1 EGFR APC SMAD4 AREG MTOR ARHA ERG MYC HRAS POLK RPS6KB1 CASP3 MAP2K1 PMC8976061__F4 Biosynthesis of the phosphonate antibiotic argolaphos A (3) ALPI ALPL ALPG PMC4066235__F3 microRNAs in Cancer Cell Response to Ionizing Radiation BAX EGFR MCL1 PTEN PMC5585627__F3 Sphingosine-1-phosphate (S1P) in estrogen receptor- (ER-) positive breast cancer EGF ABCC1 EGFR SPHK1 MTOR ABCG2 PMC10522371__F7 KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling MMP2 PTEN KIF18A MMP9 PMC5442653__F3 Potential usage of nanoparticles for splenic targeting RAB8A AKT3 PTEN MTOR PMC8234716__F3 Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives NLRP3 COX2 VCAM1 PMC8234716__F2 Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives STAT3 STAT1 IL18 PTEN PMC7840310__F6 Cell cycle program in cell death and metamorphosis CD44 VWF MMP14 CD36 VTN MMP2 CHAD MMP9 CD47 MMP11 PMC4818578__F1 NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? HMOX1 IGF1 FOXO3A IGF1R MDM2 PIN1 PMC8104092__F6 G-Protein-Coupled Receptor and Ion Channel Genes Used by Influenza Virus for Replication RGS2 SRC PMC8455272__F8 TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease NOS2 MRC1 CSF2 CCL19 CCL21 CXCL16 ARG1 PMC8104092__F7 G-Protein-Coupled Receptor and Ion Channel Genes Used by Influenza Virus for Replication ADRBK1 BTK RAF1 GSK3B CSK PC PMC7198260__F2 Ectopic lipids in insulin resistance INSR PC IRS1 PMC4818578__F2 NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? NOX5 IGF1 PAH VCAM1 MTOR NOX4 PMC6974395__F3 Fumarate hydratase in cancer: a multifaceted tumour suppressor NFU1 FH ISCU ACO2 BOLA3 KEAP1 BOLA1 FES PMC6825568__F7 Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response TOPBP1 ATR GSK3B PMC8104092__F5 G-Protein-Coupled Receptor and Ion Channel Genes Used by Influenza Virus for Replication RAP1GAP STAT3 GRB2 SRC PMC9410784__F2 Correlation of PM2.5 Exposure with Acute Attack and Steroid Sensitivity in Asthma ATF2 TNF PMC9221191__F2 Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response BAX FAS FADD PMC8004373__F7 Interaction network of CXCR family proteins (cBioPortal) PIK3CA SPR CXCR1 GNE GNB4 ACKR3 NPR2 IL8RB PMC8932232__F1 Store-operated Ca2+ entry in cardiovascular disease ORAI1 STIM1 IL13 PMC7538683__F5 Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer ATR PCNA SMAD4 PTEN MYT1 ME1 SKP2 GDA TSC2 CDK7 PRH2 SIVA1 CDK2 ATM PMC4494932__F6 Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells AFP PTEN MTOR SRC CXCR4 PMC9623297__F2 Regulatory roles of circular RNAs via autophagy in ischemic stroke RHEB TSC2 TSC1 GSK3B BNIP3 PMC5056854__F5 PPAR signaling pathway upregulated in LCMUFA group compared to control (FDR < 0.01) and olive oil group (FDR < 0.01) LPL UBC HEL-S-28 PLTP PMC11020458__F4 Direct osteogenic effects and mechanisms of RE NMs TBCE SMAD1 DKFZp781O1323 APC GSK3B FAM53B TEF CTNNB1 PMC7379200__F3 MicroRNA (miRNA) regulation in the maintenance of male hormonal balance STAR GLG1 RNF4 MEIS1 POU2F1 PTEN ABCA1 DSC1 GLI3 PMC4365602__F7 This schematic shows the numerous pro-inflammatory mediators produced by peri-implant tissue and immune cells reacting to implant debris, which can negatively affect bone turnover IL16 IL18 IL1B PMC3171751__F3 Altered gene expression during pressure overload hypertrophy OXT STAT3 CSA2 JUN BATF FAS VRK1 CPB2 ABCB11 TAF4B ATP2A2 GNAL VAMP4 MAP3K8 COL1A1 GDF15 PLAG1 EBI3 DEDD CRHR2 MAPK12 CDC27 LPP CHKA PMC11950169__F6 Key mechanisms involved in TTFields-induced activation of AKT CDH2 BAD ARHA PMC5107467__F7 Amide-linked local anesthetics induce apoptosis through apoptotic pathways (the extrinsic death receptor pathway and the intrinsic mitochondrial pathway) and MAPK pathways in human non-small-cell lung cancer cells BAX CCND1 FADD PMC11815446__F1 Metabolic pathway of Clopidogrel CYP1A2 CYP2B6 CYP2C19 CYP2C9 PMC7038167__F5 Graph of genes and processes involved in the pathway 04110: Cell cycle DBF4 CDC20 PCNA CDC6 SMAD4 MYT1 ORC3 SKP2 ORC2 CDK7 E2F4 CDK2 MDM2 PMC3107509__F1 Wnt signaling pathways WNT1 ARHA CTNNB1 PMC8197977__F3 Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer NNMT AOX1 NAMPT PMC3989729__F7 A schematic diagram illustrating the interplay between TLX and the BMP-SMAD signaling pathway in the regulation of neurogenesis and astrogenesis GFAP BMP4 SMAD4 PMC8438703__F1 Understanding microglial diversity and implications for neuronal function in health and disease TREM2 AXL CX3CR1 ADAM10 PMC2567511__F1 The tetrapyrrole pathway in plants showing intermediates and genes analyzed in this study POR CPO UROD UROS PMC9159374__F3 Amelioratory Effect of Resistant Starch on Non-alcoholic Fatty Liver Disease via the Gut-Liver Axis TG PYY TLR4 PMC8197977__F1 Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer NNMT NRK NAPRT HEL-S-90n NAMPT PMC6542994__F1 Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome MAX TH NTS NR1C1 CDA PMC5624455__F4 Leukocyte extravasation signaling pathway altered by a high-fat-diet, Taeumjowitang, and green tea in the epididymal white adipose tissue CD44 TH CRK JAM2 ARHH VASP ITGB1 ITGA4 FER PXN ARHA PMC9229764__F2 Variation in the Humoral Immune Response Induced by the Administration of the BNT162b2 Pfizer/BioNTech Vaccine: A Systematic Review CD80 FAS APC ACE2 PMC9471015__F1 Applications and prospects of genome editing in plant fatty acid and triacylglycerol biosynthesis LPA PDC PC PMC5881172__F1 Unfolded protein response SP1 SP2 ATF4 XBP1 PMC7830093__F1 Comparative view of wild-type p53 function in ESC maintenance, differentiation, and somatic-cell reprogramming of human and mouse: ESC maintenance: p53 is maintained in an inactive state in both human and mouse ESCs KLF4 MDM4 AURKA LIN28A TRIM24 SOX2 MDM2 SIRT1 PMC7184931__F1 This schematic diagram shows the metabolic pathways controlling activation and lineage specification in the immune system CD44 STAT3 RAB4A VLDLR CD36 LDLR AHR SLC1A4 FOXP3 JAK1 NDP PMC9328443__F7 SNPeffect: identifying functional roles of SNPs using metabolic networks IPP ME2 PMC7184931__F2 Metabolic control of T-cell related to tryptophan metabolism TH APC AHR MTOR PMC9328443__F6 SNPeffect: identifying functional roles of SNPs using metabolic networks DAP RGR PMC9410115__F1 Pathophysiology of Coagulation and Emerging Roles for Extracellular Vesicles in Coagulation Cascades and Disorders TF VWF APC PLG PMC9328443__F3 SNPeffect: identifying functional roles of SNPs using metabolic networks RGR PMC6278486__F3 High-energy donor UDP-GlcNAc is provided by the hexosamine biosynthetic pathway (HBP) and is connected to UDP-GalNAc and CMP-NeuAc OGA OGT NANP GNE NANS PMC4516432__F5 Models for pre-miRNA uridylation by TUT7 Pre-miRNA uridylation by TUT7/4/2 in microRNA biogenesis pathway AGO2 TUT7 TUT4 PMC6345743__F5 Comparing ECM-receptor interaction pathway for (a) DA and (b) non-DA neurons based on DEGs and DEmiR TH CA7 THBS1 COMP GAL FAS LAMC2 SV2B COL9A1 THBS3 CHAD LAMB1 SPP1 AGRN COL1A1 ITGB1 RELA SI HEL-S-11 LAMA3 PMC6311498__F1 Cartoon illustrating the intracellular distribution of ATP7A, ATP7B, and DBH DBH ATP7B ATP7A PMC3132612__F2 The major signal transduction pathway in the ER stress response ATF4 XBP1 TRAF2 PMC7184931__F3 cGAS-STING-IFN pathway activation in SLE CGAS SLC19A1 TREX1 PMC2797892__F10 Pathway induction after pathophysiologic stimulation of BSMC by three coordinate stimuli: strain, hypoxia, and damaged matrix STAT3 MTOR EIF4E PMC3677627__F5 Molecular network based on some key metabolites reversed by resina draconis or isosorbide dinitrate treatment RAMP3 PDGFD PDE11A RLN3 GPR39 UCN3 GRK4 PMC5742900__F3 Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals IDE DIO1 AHR PMC5742900__F4 p53 signaling pathway and related significant changes observed in response to postprandial serum (orange: upregulated compared to fasting serum; green: downregulated compared to fasting serum) RFWD2 ATR FAS SIAH1 PERP PTEN MTOR MYC TSC2 RAI1 CDK2 ATM PIGS MDM2 PMC5887474__F3 Canonical p53 DNA damage response pathway AURKA CDKN1A PCNA CCNB1 GADD45A PLK1 PMC3067813__F7 Model of proposed HEB, GATA3, and Notch1 interactions GFI1B NOTCH1 GATA3 PMC5426948__F2 Proposed signalling pathway showing that genetic loci deregulated through altered methylation in Beckwith-Wiedeman syndrome are upstream of pheochromocytoma-paraganglioma susceptibility genes NGF NF1 MAK MEN1 MTOR SHE MYC RET VHL PMC9425815__F1 Involvement of host microRNAs in flavivirus-induced neuropathology: An update TBK1 MAP3K7IP1 TAB3 CCR2 NFKBIA SMAD6 IRF3 PMC9425815__F4 Involvement of host microRNAs in flavivirus-induced neuropathology: An update BACH1 SOCS5 EZH2 TRAF6 PMC3675946__F6 Cell wall integrity (CWI) signaling pathway with transcriptomic expression changes during limonene stress GSC2 ROM1 HMFT1766 HEL-S-68p PMC9425815__F3 Involvement of host microRNAs in flavivirus-induced neuropathology: An update STAT3 TRIAP1 TNFAIP3 MAVS RNF11 IRF1 PTEN TRAF3 STAT1 RNF125 SOCS5 TLR7 NRF EEF1A1 NOTCH1 PMC7904692__F1 Antiviral pathways in silkworm AGO2 EGFR PTEN PMC6713920__F3 The schematic flow of biosynthetic pathway of DNJ in S C6 ADM C2 PMC8108589__F3 LRP-1 modulates neurodegeneration and neuroregeneration NGF TRADD IL16 TRAF1 TRAF2 FADD PMC7534062__F8 Schematic diagram depicting the effects and mechanisms of TPH-1 against renal fibrosis and the regulation of PAA on TPH-1 expression TPH1 APC AXIN1 CTNNB1 PMC8108589__F1 Proinflammatory pathways regulated by LRP-1: The interaction between LRP-1 and ApoE represses the formation of IRAK1–TRAF6 complex and therefore the NFKB-mediated pathway IL16 TLR4 APOE IRAK1 IRF3 TRAF6 CCL2 MYD88 PMC8667344__F1 Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor APC IL5RA IRF4 FOXP3 GATA3 PMC7074087__F7 PC inhibitor attenuated glycolytic shift and metabolic reprogramming in pulmonary hypertension HEL-S-133P GSK3B PC PAH PMC5710802__F3 RLR-mediated RNA sensing pathways IL10 RIGI MAVS TRADD TANK IRF7 IL6 FADD PMC8774167__F1 Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance ATG3 MTOR PMC11660554__F5 Alterations in the HSV-1-associated host antiviral signaling pathway in HGFs HEL-S-99n MAVS IRF7 PMC6410042__F6 Pathway analysis for PRR and IFN signaling SOCS1 INA IFIT1 IFIT3 TAP1 IFI35 MYD88 IFNG STAT1 RARB TLR4 IFITM3 NOD1 MX1 TLR7 OAS1 IFITM2 STAT2 PSMB8 IRF9 FRK RNASEL IRF1 TNF TLR3 FITM1 PMC12241104__F1 Biosynthesis of shikimate HEL107 PTS PMC8651602__F2 Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis TET2 HIF1A PRODH PYCR2 CIT PMC3316122__F2 Schematic model depicting activation of the AIM2 inflammasome by F IFNAR1 AIM2 IRF3 IL1B PMC8954241__F4 Toxic Mechanism and Biological Detoxification of Fumonisins BAX FAS TRADD MTOR TNF ATG5 FADD PMC7885408__F9 Role of SIK1 in the transition of acute kidney injury into chronic kidney disease SIK1 APC GSK3B LRP5 LRP6 CTNNB1 PMC10296498__F1 IL-33/ST2 signaling pathway activation IL33 TRAF6 MYD88 PMC2262896__F6 Interferon signaling STAT1 STAT2 PSMB8 IRF9 IFIT1 IFITM1 IRF1 JAK1 PMC2262896__F4 TCR signaling pathway CRP LAT NEK2 RAC1 TEC NEK1 CBL CRB2 SHB FYN CSK ITK LCK PMC8225190__F6 Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response RHEB TSC2 TSC1 TFEB PTEN PMC9113089__F2 Glioma and the gut–brain axis: opportunities and future perspectives CCK PYY IL1B PMC2311292__F2 Pathway representation of all the tryptophan related genes analyzed GFER GCDH PRMT2 KYNU CYP1B1 LCMT1 INS ALDH3A2 MAOA CARM1 LCMT2 OGDH CASP3 ALDH9A1 AADAT METTL6 PMC7746821__F1 Summary of drug resistance in tumor immunotherapy TIGIT CD24 PBRM1 ATM TNF CD47 LAG3 PMC8110656__F8 I2 imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway BAX BAD GFAP GSK3B PMC7460823__F1 Representation of the metabolites and related pathways involved in the Epithelial-Mesenchymal transition (EMT) process in cancer LATS1 ACSS2 TAAR9 CAD FFAR3 SNAI1 TLR4 SMAD2 MMP9 FFAR2 YAP1 TAAR8 PMC9396337__F9 Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt/GSK-3B signaling HDAC3 HDAC1 BAX GFAP GSK3B IL6 BDNF PMC3523725__F7 PPARG COUNTERACTS LRP1-INDUCED VASCULAR CALCIFICATION BY INHIBITING A WNT5A SIGNALING PATHWAY SOX9 PMC10779188__F1 BRAF signaling pathway and targeted therapies in the BRAF pathway BRAF GRB2 MTOR PMC12130703__F0 TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus CGAS IRF3 TRIM21 PMC9707496__F2 Dysregulation of FBW7 in malignant lymphoproliferative disorders STAT3 CREBBP EP300 PMC8959654__F1 LncRNAs Mediating Wnt/Beta-Catenin Signaling in HCC CTNNB1 PMC8959654__F2 LncRNAs Mediating Wnt/Beta-Catenin Signaling in HCC CTNNB1 PMC8959654__F3 LncRNAs Mediating Wnt/Beta-Catenin Signaling in HCC DKK1 PMC10341994__F8 Mechanism of AM polarization toward M1 phenotype and early apoptosis induced by rLLB exposure BAX BCL2 IL6 PMC12232702__F5 AKT phosphorylates USP4 RHEB TBR1 USP4 SMAD4 TRAF6 TRAF2 PMC5710802__F1 cGAS-STING pathway senses cytosolic dsDNA IL10 CGAS PQBP1 IRF3 IL6 PMC6562601__F1 De novo pyrimidine and purine synthesis pathways PAICS CAD UMPS HEL-S-70p PFAS DHODH ADSL PMC9569764__F8 Developmental Transcriptome Analysis of Red-Spotted Apollo Butterfly, Parnassius bremeri FAS MALL PMC2783859__F3A Identification of Actively Translated mRNA Transcripts in a Rat Model of Early Stage Colon Carcinogenesis CCND3 DVL1 JUN CEND1 APC GSK3B PRKCZ MAPK9 PPP2R5C ARHA MYC PRKCH PRKCE CSNK1E FOSL1 PRKCA LDLR MAPK10 FZD1 PMC4667861__F1 Signalling pathways and mechanisms regulated by vagal activation TFAM STAT3 PMC6524401__F1 Overexpression of IL-6 and its potential negative consequences on the viral immune response APC IL4 PMC6522855__F2 Complement pathway CD59 C2 C1S CR2 CD46 CD55 C4A C4B_2 PMC5132394__F8 iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration WNT5B WNT3A APC GSK3B MMP3 CTNNB1 PMC9076740__F2 Maturation of beta cells: lessons from in vivo and in vitro models ACLY GOT2 MTOR ME1 HEL-S-30 GPD1 GPD2 SLC25A12 SLC25A11 SLC25A1 PC HEL-S-32 MDH2 HEL-S-26 PMC8576424__F2 GIP Receptor in the CNS for the Pathogenesis of Obesity GIP SOCS3 GIPR PMC1779567__F6 Functional dissection of signaling modules in human TReg cells S100A4 TP53INP1 TNFRSF10B ID2 PIM1 APC IL7R MYC SATB1 GATA3 TNFRSF18 PTTG1 TRAF1 STAT4 FOXP3 MDM2 FHIT FADD PMC9311382__F1 Gut microbiota in sarcopenia and heart failure IL1R1 SMAD2 BNIP3 IGF1R IL6 MTOR TNF TRIM63 PMC6385748__F7 Graphical representation demonstrating the role of PDK4 in obesity-induced MAM formation and skeletal muscle IR PDK4 FOXO1 IRS1 PMC2871659__F1 Overall scheme of key genetic and epigenetic events in colorectal tumorigenesis BAX COX2 APC BRAF CTNNB1 PMC4917669__F2 The MyD88-independent pathway TBK1 TLR4 MAL CD14 IRAK1 IRF3 IRF7 TRAF3 TRAF6 LBP PMC4917669__F4 Graphical abstract TLR4 IRF3 IRF7 MYD88 PMC12146001__F2 Introduction and optimization of lanosterol biosynthesis pathway in E LST1 IPP SMO PMC4917669__F1 MyD88-dependent pathway TLR4 CD14 IRAK1 IRAK2 TRAF6 LBP IRAK4 PMC9569207__F8 Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases BAX TLR4 PMC4320499__F6 MM patient 3 profile schematic MAP3K12 MCL1 HIF1A MAP3K11 PMAIP1 RCE1 MAP4K2 MAPK8 CTNNB1 MAPK14 BCL2L1 CCND1 NOTCH1 CDK4 SP1 AIP KRAS RBPJ RHEB TSC2 NR1C1 TSC1 BAG3 MAP3K1 CDKN1A CASP3 CDK2 BCL2 PMC5278463__F7 Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism TFEB IRF3 TREX1 PMC11247557__F9 Pyroptotic macrophages promote proliferation and chemotherapy resistance of peripheral T‐cell lymphoma via TLR4 signaling pathway GSDMD NLRP3 TLR4 BCL2 TRAF1 BIRC3 PMC8921549__F7 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury RB1 BAX FAS KEAP1 FADD PMC8921549__F3 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury RB1 BAX FAS FADD PMC8921549__F4 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury RB1 BAX SIRT1 PMC8921549__F5 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury RB1 BAX KEAP1 PMC4276460__F7 HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells STAT3 FADD PMC7322915__F1 Effect of caffeine on Cdc25 regulation in S RAD1 CDS1 APC WEE1 PMC6370048__F2 Downstream effectors and upstream regulatory pathways of RKIP CDH2 STAT3 HMGA2 GSK3B BRAF EZH2 PTEN YY1 CTNNB1 ADRBK1 BACH1 VCAM1 CXCR4 NOTCH1 PMC5961473__F7 miRNA–gene interaction network.Notes: miRNAs are shown in pink, genes from Gmagenta are shown in magenta and genes from Ggreen are shown in green PLN PPP1R12B HEL-S-273 COL1A2 ATP2B4 THBS2 AGTR1 ITGB3 TPM1 MYLK CTNNA3 PPP2R2B COL5A3 DMD SCN4B PMC2048738__F1 Reactions of the Calvin cycle, starch synthesis, photosynthetic carbon oxygenation pathway, triose-P export, and Suc synthesis represented in the model (Supplemental Appendix S1, A and B) HPR GCA GIP PMC11882405__F10 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action SOCS1 STAT3 BAX PMC2099624__F9 Schematic model of Nrf2 regulation by Keap1 RBX1 KEAP1 MAF PMC9703913__F2 Cofilin Acts as a Booster for Progression of Malignant Tumors Represented by Glioma CDC42 TGFBR2 ROCK2 PAK1 ROCK1 RHO HEL-S-52 TWIST1 VSIG4 TGFBR1 PMC3784815__F3 Kidney immune activation against ischemia-reperfusion and transplant injury HEL-S-62p APC CS PMC9371855__F6 Rosin Derivative IDOAMP Inhibits Prostate Cancer Growth via Activating RIPK1/RIPK3/MLKL Signaling Pathway RIPK3 HMGB1 MLKL GPX4 RIPK1 FADD PMC4676894__F9 Mechanism-based combinatorial experimental regimens aimed at disrupting known oncogenic cooperation pathways in ABC-DLBCLs CD40 STAT3 SYK SMAD1 DKFZp781O1323 CARD11 RELB PTEN IRF4 MYC IRAK4 MYD88 BCL10 BCR BCL2 JAK1 BCL6 PMC7601443__F3 Crosstalk between adipose tissue clock and important signaling targets KLF15 NAMPT MTOR SIRT1 PMC6314025__F3 Model unifying proteostasis in ER and cytoplasm of Plasmodium falciparum in mechanisms of artemisinin resistance PI3 ELF2 EIF2A PMC4676894__F5 Proposed model for the postulated functions of STAT1 in HR-DLBCL-NOS IFNG STAT1 IL10 IL6 JAK1 PMC4676894__F2 Oncogenic (deregulated) intracellular signaling pathways in germinal center B cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) CD58 CD2 S1PR2 P2RY8 BCL2 EZH2 PTEN RHO BCL6 PMC7905558__F7 Experimental framework LATS1 LATS2 MMP2 CTNNB1 PMC4676894__F3 Oncogenic (deregulated) intracellular signaling pathways in activated B cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) CD40 STAT3 SYK CD79B IL10 CD2 CD79A CARD11 IL6 IRF4 IRAK4 MYD88 CD58 BCL10 BCR BCL2 EP300 JAK1 BCL6 PMC9644577__F2 Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation FITM2 APC CTNNB1 PMC2663399__F2 DNA Damage Tolerance: When It’s OK to Make Mistakes RAD18 PALM PCNA PMC5549707__F8 4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice MAP3K7IP1 TIRAP TRAF6 MYD88 PMC8068170__F1 WNT signaling pathways JUN APC LRP5 LRP6 ARHA CTNNB1 PMC8534197__F8 Molecular Signature Expands the Landscape of Driver Negative Thyroid Cancers FLT3 SLC3A2 STAT3 RASSF1 EGFR GSK3B TTI1 PTEN FLCN MYC CTNNB1 IFNG CSF2RB OSMR TBC1D7 MDM2 GHR CCND1 CASP9 PIM2 PIM1 STAT2 APC FZD7 LRP6 RELN DEPTOR IRS1 RHEB MLST8 TSC2 TSC1 XB CBY1 IFNAR2 IFNAR1 ERBB2 STAT4 CASTOR2 GRB2 SESN2 BIRC2 PMC2663399__F5 DNA Damage Tolerance: When It’s OK to Make Mistakes RAD18 ATR ATRIP PCNA PMC6623974__F2 Functional interaction network analysis PTCH1 PLAUR SHH VCAM1 CCL2 TRAF2 PMC1360652__F6 Working model for the effects of 15d-PGJ2 and thiazolidinediones on TNF-stimulated NFKB activation and COX2 expression PPARG COX2 TNF PMC4615939__F11 Proposed scheme for mechanical stretch-induced VSMC hypertrophy through leptin synthesis, RhoA/ROCK pathway, ROS formation, and GATA-4 nuclear translocation ARHA RHO GATA4 PMC12205666__F8 SiNPs inducing pulmonary genotoxicity and malignant transformation via autophagy dysfunction KEAP1 RNF168 SQSTM1 MDM2 PMC5378159__F1 Synthesis and metabolism of repressors of SREBP processing and LXR ligands, 24S,25-EC, 25-HC, of the EBI2 ligand 7A,25-diHC and of the RORGt ligand 7B,26-diHC CYP7A1 CH25H HSD11B1 CYP46A1 CYP7B1 CYP27A1 PMC5378159__F3 Synthesis and metabolism of oxysterol modulators of Hh signalling CYP7A1 HSD11B1 DHCR7 CYP27A1 PMC5286373__F2 Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype HEL-S-133P PHGDH PMC3771080__F1 Pathway analysis depicting cytokine and cytokine receptor interactions relative to position in the cellular environment IL15 IL10 TGFB1 TNFRSF1A IL4 IL7R IL1A IL6 IL15RA TNF TNFRSF10A TGFBR1 IFNG IFNGR2 IFNAR2 IL1RN PMC5286373__F3 Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype MTHFD2 PHGDH MTHFD1L PSAT1 HEL-S-51e PSPH PMC6009840__F1 Metabolic Reprogramming in Kidney Cancer ASS1 ASL GLS HEL-S-133P FASN HEL-S-5 GPX1 PMC2933389__F9 Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications RHEB TSC2 TSC1 MTOR EIF4E PMC6009840__F2 Metabolic Reprogramming in Kidney Cancer ALDH2 DDC MAOA PMC7760867__F1 Relapse-associated genes and pathways interacting with R-CHOP immunochemotherapy BAX ATR BCR MCL1 BCL2 ATM CD19 MDM2 MYC PMC6476918__F1 Canonical and alternative Wnt signaling pathways LATS1 JUN LATS2 DKK1 APC ATF2 ARHA LEF1 RAC1 CTNNB1 PMC11701040__F2 Mechanisms by which mitochondrial dysfunction drives the development of chemotolerance in colorectal cancer (CRC): mitochondrial dysfunction drives CRC cell proliferation and chemotolerance CDC2 OTUD6A MTFR2 ARF1 BRAF CTNNB1 PMC8264993__F8 AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury AXL ABCA1 PMC10301029__F1 Tyrosine kinase (EGF pathway) and Wnt/Beta-catenin pathways STAT3 EGF FRS2 EGFR APC LRP5 LRP6 MMP9 CTNNB1 CRK STAT1 COX2 GRB2 RND1 PMC3640986__F2 Steroid Receptor Coactivator-3 as a Potential Molecular Target for Cancer Therapy IGF1 IGF1R MIF IRS1 IL1B PMC10301029__F2 Overlap between the tyrosine kinase pathway, Wnt/Beta-catenin, and prostaglandin inflammation pathways COX2 CTNNB1 FGF2 PMC10301029__F3 EMT transition pathway STAT3 SMAD2 HEL-S-28 TNF SHE CTNNB1 HDAC3 HDAC1 ZEB2 GRB2 SRC HDAC2 LEF1 PMC6627503__F2 Mitochondrial antiviral response MAVS IRF3 IRF7 PMC11965601__F1 LBP in inhibiting retinal cell apoptosis MTOR LBP IL1B PMC4339376__F10 Effects of Magnolol and Honokiol on Adhesion, Yeast-Hyphal Transition, and Formation of Biofilm by Candida albicans TPK1 ECE1 PMC11965601__F3 Flavonoids in inhibiting retinal cell apoptosis NGF BDNF PMC7433927__F1 Interrelationships among components of the 1-carbon metabolism pathway (Methionine cycle, Folate cycle, and Transsulfuration pathway) SMS SRM DHFR CTH MTRR HEL-S-61p TYMS MTOR MTR FTCD PMC8654269__F1 IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies TIRAP TIFAB IRAK1 TRAF6 MYD88 PMC11965601__F6 Autophagy regulation in Lycium barbarum L TSC2 ULK1 ULK2 LBP PMC2678718__F1 Conversion of subendothelial macrophages into cholesterol-laden foam cells is believed to constitute the foundation of the atherosclerotic lesion FYN LYN MARCO CD68 PMC5032153__F1 Notch signalling pathway ADAM17 ECD DLL4 PMC8369418__F1 NAD+ in Alzheimer’s Disease: Molecular Mechanisms and Systematic Therapeutic Evidence Obtained in vivo NRK NAPRT HEL-S-90n NMNAT1 KYNU KMO SLC22A3 NMNAT2 AFMID SLC12A8 SARM1 SLC36A4 SLC25A51 HAAO NNT NMNAT3 PMC5079664__F1 CDK4-CDK6 protect DNMT1 from autophagy PML CDK4 PMC4799531__F1 The central metabolic pathways leading to n-butanol in E HBD PMC5368219__F1 Alterations in histone methylation in pediatric and adult high-grade glioma CHTOP EGFR BRAF PMC9382911__F1 Pyruvate as a Potential Beneficial Anion in Resuscitation Fluids PC PMC11900823__F7 Mechanism of BRD7 inhibiting immune escape of NPC STAT3 BRD7 MTOR PMC9304652__F2 Research Progress on Structure and Anti-Gynecological Malignant Tumor of Shikonin STAT3 BAX MTOR PMC3191034__F7 Postulated model for GRTH negative autocrine molecular mechanism of regulation of androgen synthesis in Leydig cells STAR HMGCR PMC8441359__F2 Chronic low‐grade inflammation in heart failure with preserved ejection fraction IL1R1 GSDMD NLRP3 TNF IL1B PMC8478560__F2 Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer STXBP4 HOXD10 BAD TPD52 CTNNB1 PMC4822552__F4 Serum transferrin carrying the xeno-tetrasaccharide NeuAc-Gal-GlcNAc2 is a biomarker of ALG1-CDG GAL RFT1 ALG1 PMC3243745__F6 Metabolic pathways illustrating TCDD-elicited changes in the mouse (A) and rat (B) LPL PGP LPIN2 GPAT2 AIDA LIPC GPD2 ALDOB DGAT2 PAK1 HEL-S-162eP HEL-S-69p CHDH CHKA PMC6193072__F1 Canonical NFKB pathway BCL10 RELB FOXP3 CXCR4 CYLD PMC4622839__F1 PIK3/AKT/mTOR signaling pathway in acute myeloid leukemia MLST8 BAD RICTOR PTEN MTOR EIF4E PMC6348597__F1 The signaling pathway implicated in VIDD development TLR4 MTOR SRC PMC6275407__F2 T helper cell differentiation signaling pathway CD40 STAT3 ICOS CD80 TGFA IL21R CXCR5 STAT4 FOXP3 IL23R IL6R PMC7667157__F7 ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway NOTCH1 PMC4234172__F2 Signaling pathways employed by CSCs: Distinct combinations of paracrine and juxtracrine signals induce the EMT in different contexts ROR1 FZD5 STAT3 SMAD2 LRP5 SMAD4 SMO FOS CTNNB1 PMC3892554__F2 TRB3 at the crossroads of ER stress and mTORC function ATF4 MTOR EIF2A PMC9568463__F8 HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress HERC2 ATF2 GPX1 HEL-S-44 PMC5761485__F1 Biosynthetic pathway of steroid sulfates HSD3B2 STAR CYP17A1 CYP11A1 PMC5445662__F1 Intracellular signaling pathways associated with IR-induced cell death modalities RIPK3 BAX CASP9 TSC2 FAS CASP3 ATM PTEN MTOR ULK2 PMC2769199__F8 Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice TLR3 TLR4 MAL IRF3 MYD88 PMC6027703__F5 Relationship between Beta-catenin, MEN1, and NCOR1 mutations and the Wnt signaling pathway summarized NCOR1 MEN1 CTNNB1 PMC7642974__F9 The autophagy pathway by E3 ubiquitin ligases TRIM32 PINK1 VPS11 WIPI2 ULK1 FBXW11 LRSAM1 TRAF6 DEPTOR HUWE1 HERC2 ATG101 ATG12 TFEB AMBRA1 OPTN ATG5 CRBN PMC6120695__F2 Secreted immunomodulatory factors transcriptionally induced by oncogenic Kras signaling CXCL5 CXCL1 CXCL2 KRAS CXCL8 PMC5394116__F1 Although a myriad of intracellular signaling is involved in passive therapies, their pathways show some overlap CTLA4 MTOR CXCR4 PMC5761026__F1 Simplified scheme for one-carbon metabolism DHFR MTRR PMC2593475__F1 PI3K/PTEN/Akt/mTOR Pathway BAD PTEN MTOR PMC2674579__F1 GST-MDA-7 causes PERK-dependent vacuolization and JNK pathway activation in transformed cells that leads to cell death BAX BAD PMC4203662__F1 Targeting the PI3K/AKT/mTOR pathway: potential for lung cancer treatment SGK1 PTEN PMC7192953__F6 Interregulation of the PIKK family members DNA-PKcs and ATM and their downstream substrates in the DDR pathway activated following DSB induction by IR RBX1 H2AX ATM HIF1A PLK1 PMC4019000__F1 Dietary Fatty Acids and the Aging Brain TES IDE LOX GSK3A INSR RXRA ABO GSK3B PTEN PDK2 BDNF PMC7192953__F4 Pathways of DNA double-strand break repair RAD51 BRCA1 BRCA2 POLE PARP1 PMC8396177__F1 Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease TLR4 SRC MPO PMC6120695__F3 Cooperation of Kras-mutant tumor cells with pancreatic stellate cells in tumor microenvironment (TME) immunomodulation STAT3 CXCL12 IL6 CXCL10 KRAS PMC3765962__F2 Important molecular pathways and drug targets in RCC FLT4 HEL-S-133P HEL-S-68p EPO FLT1 KDR MTOR VHL PMC9434839__F3 Oxidative stress in ovarian aging: a review BAD KEAP1 NQO1 MTOR PMC5381329__F1 Homocysteine metabolic pathway CTH MTR PMC3548977__F1 Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists HHIP BCL2 SMO MYC IGF2 PMC8204050__F7 Key Macrophage Responses to Infection With Mycobacterium tuberculosis Are Co-Regulated by microRNAs and DNA Methylation RHEB TSC2 FAS POC1A CD36 F2 CYC1 CFTR INS SIRT1 PMC9457687__F5 Single cell states of the NFKB signaling pathway C2 IL6 CXCL8 UBB IL1B PMC2235216__F1 Arsenic-induced acquired androgen independence JUN FOS PMC8074247__F6 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer KLF4 ATR STAC APC PC ATM RHO PMC8074247__F4 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer MAPDA MAK CCR3 APP PMC10135714__F10 Schematic illustration shows the protective effect of extract of Lonicera japonica in particulate-matter (PM)2 BAX TNF MYD88 PMC8074247__F8 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer POR NGF ATR EMSY PDPK1 CDK2 ATM CS PMC8783446__F10 Novel Gamma-sarcoglycan interactors in murine muscle membranes SVIL C12orf57 EPB41L4A SGCD RNPEP SGCE SMP1 TNS2 BRAF SGCG SGCZ PRDX3 HEL-S-80p NR3A2 DMD NACA DAG1 ABHD4 SPN PURA PAICS TACC2 TRIM25 ERBB2 NCL PMC6274615__F1 KEGG-defined p53 signaling pathway with dysregulated mRNA and miRNA highlighted RFWD2 BAX CASP9 TSC2 ATR BAD PERP CDK2 ATM PTEN MDM2 MYC PMC8465847__F1 Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer PRF1 CX3CR1 CD69 CXCR5 TOX LAG3 RUNX3 PMC6408950__F1 RBP-J functions as a key negative regulator of osteoclastogenesis and inflammatory bone resorption PLCG2 NFATC1 TNF PMC2924379__F2 Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis HTRA2 BAX BAD CASP8 TRADD TRAF6 NAIP CASP3 BOK HRK BIK DIABLO FADD PMC11842356__F2 Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics TBK1 CGAS IRF3 CCL5 CXCL10 TNF PMC8481092__F1 MiR-2392 in driving SARS-CoV-2 infection PFKFB4 ND4 APP ND2 RHO HEL-S-30 PMC2920679__F1 Regulation of mammalian target of rapamycin (mTOR) signaling functions RHEB TSC2 FBXW7 TSC1 PMC5035594__F1 Anticipatory UPR Activation: A Protective Pathway and Target in Cancer EEF2K EEF2 EIF2A PMC5035594__F2 Anticipatory UPR Activation: A Protective Pathway and Target in Cancer EGF NGF HGF BCR SRC PMC2709429__F11 Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin CD36 DDC PMC11880921__F1 Biosynthesis pathway of GD2 (5) UGCG GAL B4GALNT1 ST8SIA1 B4GALT5 B3GALT4 PMC3272624__F1 Schematic depicting mTORC1 signaling in a NAC a medium spiny neuron with anterogradely transported BDNF being released from a VTA dopamine neuron terminal and glutamate released from a prefrontal cortex projection neuron RHEB TSC2 TSC1 MTOR BDNF PMC6352924__F2 Tumour necrosis factor receptor 1 (TNFR1) signalling pathway RIPK3 TRADD MLKL TAB3 TRAF5 RIPK1 TNF CYLD TRAF2 FADD PMC7642974__F1 Action and classification of E3 ubiquitin ligases causing neurological diseases in human TRIM32 FBXO31 ITCH FBXW11 TRIM2 LRSAM1 ASB10 TRAF3 HECW2 RNF170 PEX10 HEL-S-305 HUWE1 TRIP12 FBXL7 HERC2 RHOBTB2 RNF125 MID1 TOPORS RNF168 UBE3B CRBN HERC1 VPS11 RANBP2 HACE1 RBX1 DDB1 CUL4B FBXO7 SKP1 ELOC PMC5830185__F2 Current evidence on statin use and prostate cancer prevention: are we there yet? EGF CDK2 RHO MTOR PMC5840201__F1 Neurosteroid synthesis in the retina CYP21A2 CYP17A1 CYP11A1 CYP46A1 CYP27A1 PMC5543040__F1 Gonadotropin-releasing hormone (GnRH) receptor signal transduction in human cancers BAX EGF JUND GNRHR BRCA1 EGFR SRC CCND1 PMC2865534__F1 Heterologous Expression and Maturation of an NADP-Dependent [NiFe]-Hydrogenase: A Key Enzyme in Biofuel Production HPD CP PMC2814769__F5 Primary Cilium as a Complex Signaling Center APC GSK3B LRP5 LRP6 ARHA CTNNB1 PMC4148120__F7 MAPK pathway as an apoptosis enhancer in melanoma SPRED1 BRAF PMC5006112__F1 MTOR pathway TSC2 RICTOR STK11 TSC1 EGFR PTEN MTOR PMC5817802__F3 Model for TMPRSS2-ERG regulation of the IGF1R gene IGF1 ERG PMC7525950__F2 PI3K-mTOR autophagy pathway utilizes PIP3 lipid signaling RHEB TSC2 TSC1 ULK1 PTEN PMC7007879__F7 Potential differences between Socs3 and Cish gene expression SOCS3 CISH BRD2 PMC2861325__F9 An Ingenuity pathway analysis containing about half of the genes in subfactor 8 of Myc factor 6 HEL164 AURKA BUB1B ARF1 NEK2 MYC PSMD2 LRRC59 HEL-S-276 HNRPR PROX1 GOSR2 TTK RPL7 HEL-S-44 PSMD11 BACH2 ARRB2 UBE2S GLO1 TUBG1 HEL-S-94n RAC1 TUBA1C EIF4G1 AURKB HEL-S-162eP HEL-S-69p CHEK1 YWHAZ PMC6387281__F1 Schematic overview of the autophagy process and genetic and drug targets to inhibit specific aspects of autophagy ATG10 ATG3 ATG12 ATG5 ULK2 PMC8557683__F6 Circular RNA expression profiles in human bronchial epithelial cells treated with beryllium sulfate BAD GRAP IRF9 PMC1890551__F1 Eumelanin synthesis pathway and gene duplications in vertebrates OCA2 DCT TYRP1 PMC1550314__F1 Ras activation in response to phorbol ester proceeds independently of the EGFR via an unconventional nucleotide-exchange factor system in COS-7 cells HBEGF EGFR GRB2 PMC7261339__F1 RhoA/ROCK signalling pathway in PH pathogenesis SMAD1 CDK2 PTEN ARHA CDK4 PMC1890551__F4 Pteridine synthesis pathway and gene duplications in vertebrates SPR PTS XDH GCHFR PMC7935738__F1 Hepatic bile acid metabolism CYP7A1 FGFR4 CYP27A1 PMC5969560__F1 Mitochondrial complex III Rieske Fe-S protein processing and assembly UQCRC1 UQCRB UQCRFS1 UQCRC2 FES CYC1 TTC19 UQCRH PMC3586680__F1 Schematic diagrams of WWOX structure and its role in signaling ERBB4 APC WWOX SRC RUNX2 PMC7325873__F2 Graphical representation of DENV life cycle and subversion of the innate immune response: The virus enters the host cell through receptor mediated endocytosis or antibody dependent enhancement STAT1 MAVS TLR3 STAT2 TLR4 FURIN PMC3235041__F1 SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen CYP1A2 CYP2B6 SULT1A1 CYP2C19 CYP2C9 CYP3A4 PMC5653458__F1 Emerging roles for the lysosome in lipid metabolism NPC2 LIPA ACAT1 NPC1 LDLR PMC4403552__F1 Fabric of signaling cascades can be activated by astrocyte Gq-GPCRs CDC42 ADRBK1 DGKA GSK3B MARCKS CSK PMC4658486__F4 Pathophysiology and management of CVD C6 HEL-S-62p C2 VCAM1 PMC4104073__F2 Splicing regulation of the androgen receptor (AR) and phosphoinositide 3-kinase (PI3K) signaling pathways RHEB FKBP5 TSC2 TSC1 PTEN MYC SND1 FGFR2 PMC8448888__F5 Suggested scheme of the SNO-dependent mTOR activation in the ASD and AD mouse models RPS6 FZD10 MAPKAPK2 GSK3B AGTR1 TRAF6 DEPTOR RAC1 RHEB MLST8 TSC2 TSC1 TBC1D7 PMC8231932__F4 Functions of Coronavirus Accessory Proteins: Overview of the State of the Art BAX FAS BCL2 ATF4 EIF2A XBP1 FADD PMC2268988__F3 Life and death decisions by the E2F transcription factors BAX TOPBP1 BAD MDM2 APAF1 SIRT1 PMC8448888__F3 Clustering analysis of the SNOed proteins in ASD and AD mouse models POP4 GNAS APBA1 MYLK CPLX2 APP ADNP PMC10379139__F2 Genetic Risk Factors Related to Coronary Artery Disease and Role of Transforming Growth Factor Beta 1 Polymorphisms TGFBR2 TGFB1 SMAD2 TGFBR3 SMAD4 TGFBR1 PMC8815029__F1 Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications PIEZO1 ARHA PMC9456274__F1 Ceramide Acyl Chain Length and Its Relevance to Intracellular Lipid Regulation CERS3 CERS5 CER1 PMC8231932__F2 Functions of Coronavirus Accessory Proteins: Overview of the State of the Art TBK1 MAVS IRF3 TRAF3 TYK2 PMC8231932__F3 Functions of Coronavirus Accessory Proteins: Overview of the State of the Art NLRP3 ATF2 TRAF3 PMC3600733__F2 The quantitative system pharmacology approach for a schizophrenia model is based on actual preclinical neurophysiology and human neuroanatomy HEL-S-11 KDR PMC8191213__F3 Overexpression of DDIT4 and TPTEP1 are associated with metastasis and advanced stages in colorectal cancer patients: a study utilizing bioinformatics prediction and experimental validation VSNL1 SMNDC1 LAMC2 SULF1 RUNX2 PMC6572052__F3 Transforming growth factorB (TGFB) signaling pathway with marked expression levels of deregulated genes LTBP1 SP1 SMAD4 NODAL ARHA TNF PITX2 HFE2 TGFBR1 BAMBI IFNG FST NEO1 SKP1 SMURF2 PMC6572052__F4 Hippo Signaling pathway with marked expression levels of deregulated genes RASSF6 NID1 GNE ID2 AFP PATJ AMOT APC KERA SOX2 SCRIB AREG PMC6281221__F5 Analysis of the transcriptome data in Litopenaeus vannamei reveals the immune basis and predicts the hub regulation-genes in response to high-pH stress VIP RYR2 HCN2 JUN BAD RAF1 VAV2 GIP GHRL ARHA RHO FOS HCN4 NR1C1 TIAM1 SOX9 PAK1 CFTR HEL-S-11 NPY AMH BDNF GLI3 PMC9081902__F2 Processing of dietary lipids for chylomicrons synthesis LPA TG APOA4 DENND5B MTTP ARFRP1 CD36 AIDA PMC6539587__F1 Sequence information of the overexpression vector HIF-1Alpha-pcDNA3.0 NDE1 PMC9006750__F1 Pathway choice in replication-coupled ICL repair NEIL3 TRAIP FANCM VCP PMC6816781__F6 Signaling pathway regarding the cell cycle regulation in human bladder transitional carcinoma/BFTC-905 cells after stimulated by LSS CDC2 SMAD1 CDK6 DKFZp781O1323 CCNE1 WEE1 CDK2 CCNA2 CCND1 CDK4 PMC11822028__F3 Transcriptomic and proteomic profiles of G. subvermispora and T. versicolor of 4-HBA catabolic pathways, TCA cycle, and glyoxylate shunt under different cultivation conditions FH CS PMC7910522__F3 Retinoids in the visual cycle: role of the retinal G protein-coupled receptor RPE RDH8 LRAT RPE65 RDH5 PMC9163413__F8 Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model TLR4 TRAF6 IL1B MYD88 PMC3266783__F2 Basal cell carcinoma — molecular biology and potential new therapies SPOP HHIP KIF7 BOC PTCH1 GSK3B SMO GAS1 PMC2749259__F2 Hypothetical diagram of possible sites of action of non-opioids in the regulatory pathway of IL-6 STAT3 STAT1 SOCS3 JAK1 PMC5500325__F7 Nutritional and reproductive signaling revealed by comparative gene expression analysis in Chrysopa pallens (Rambur) at different nutritional statuses RHEB TSC2 BAD FAS HEL-S-11 GRB2 MTOR INS PMC9047912__F1 Genetic Polymorphisms in microRNA Genes Targeting PI3K/Akt Signal Pathway Modulate Cervical Cancer Susceptibility in a Chinese Population CRK CBL CRKL BCL2 TRAF6 IKBKG PMC3693156__F1 Cholesterol synthesis pathway CDC42 ARHA RAC1 PMC3705986__F7 Schematic diagram that describes neuroprotective effects of SUL against ABeta-induced oxidative cell death in AD BAX KEAP1 NQO1 CS PMC11760869__F1 Role of the IHH/PTHrP signaling pathway in regulating chondrocyte hypertrophy PTCH1 IHH SMO RUNX2 PMC6260216__F8 Scheme summarizing the protective effects of miR-27a on LPS-induced acute lung injury via the inhibiting TLR4/MyD88/NFKB activation TLR4 IL1B MYD88 PMC9582513__F3 DNA damage checkpoint execution and the rules of its disengagement TOPBP1 ATR ATRIP DNA2 BRCA1 BRCA2 ATM MDC1 BLM PMC8774043__F7 Extracellular HSP90A Induces MyD88-IRAK Complex-Associated IKKA/B−NFKB/IRF3 and JAK2/TYK2−STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization STAT3 SEC22B IL10 TLR4 IRAK1 IRF3 CD163 TNF TYK2 IRAK4 MYD88 PMC10891274__F2 YAP/TAZ in fibroblast-like synovial cells (FLS) and its related signaling pathway involved in RA TEAD2 TEAD3 TEAD4 PMC11760869__F2 Roles of the WNT, BMP, and TGFB signaling pathways in regulating chondrocyte hypertrophy SMAD1 DKFZp781O1323 SMAD2 APC LRP5 SMAD4 LRP6 RUNX2 CTNNB1 ACAN SOX9 BMP4 BMP2 PMC11760869__F3 Roles of the hypoxia, inflammatory (NFKB and VEGF), FGF, YAP, and mTOR signaling pathways in regulating chondrocyte hypertrophy MTOR RUNX2 PMC3360882__F8 Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals CD37 GSK3B CTNNB1 PMC5216724__F6 EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway EGR1 HOXD3 EGFR PMC6149728__F1 Schematic model for IL-1 mediated induction of IL-22 in cancer NLRP3 IL16 AHR IL1B PMC6944604__F5 The roles of ADAR2-mediated RNA editing in cancer development SLC22A3 IGFBP7 PMC4085722__F2 Regulation of protein trafficking, receptor signaling, and protein clearance by ubiquitination in Alzheimer's disease FBXO2 FBXW7 APC APP MDM2 CCNB1 PMC6048292__F1 Ferroptosis and its molecular regulation by Nrf2 GPX4 HEL-S-64p PMC10933339__F9 Schematic model of the contributor and potential mechanism of KAL in the occurrence and development of NAFLD KLF4 ABHD5 LRP6 PNPLA2 PMC10891274__F1 YAP/TAZ activity is tightly regulated via Hippo signaling LATS1 MOB1A MOBKL1A LATS2 TEAD2 TEAD3 BPI TEAD4 PMC5142168__F11 Inhibition of HCO3− absorption by HMGB1 in the MTAL HMGB1 ROCK1 RHO PMC6944604__F2 The roles of ADAR1-mediated RNA editing in Multiple myeloma (MM), basal cell carcinoma (BCC) and medulloblastoma (MB) DYRK1A SUFU NEIL1 PMC2171390__F7 Calcium-independent microtubule-dependent pathway is required for FcɛRI-mediated degranulation in mast cells FYN LYN ARHA GAB2 PMC10383295__F2 High levels of ROS promote cancer cell growth, proliferation, invasion, and metastasis SSB PMC10383295__F3 Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells TH BAX BAD TRADD BRCA1 MTOR FADD PMC8000459__F3 GP6 Signaling Pathway in HS line of Japanese quail GP6 BTK ARHG LAT SCHIP1 LYN RAC1 PMC7047328__F2 Tryptophan breakdown via the kynurenine pathway and its interactions with the immune system: This figure illustrates tryptophan breakdown via the kynurenine pathway HEL-S-90n IDO1 KMO WAS AHR IDO2 PMC5322732__F6 Summary and pathway schematic PIK3CA KEAP1 PIK3R1 SMAD4 MYC MAPK3 MAPK14 RB1 CDK6 NF1 ARID1B ERRFI1 CCAR1 PBRM1 MAP6 ARID2 NRAS ZC3H18 MAPK1 MED23 USP28 ACVR2A HRAS RHEB TSC2 TSC1 SPRED1 MAP3K1 CDKN1A CDKN1B RXRA MAX ARID1A EGFR BRAF PTEN MTOR TGFBR2 GNB1 MAP2K4 GADD45B ATM NF2 CCND1 MAP2K3 CDK4 FOXA1 CIC JUN PHF6 KRAS PAWR ERBB2 KDM5C MAP2K1 DDX3X PMC7539315__F5 Transcriptome Changes in Colorectal Cancer Cells upon Treatment with Avicequinone B TF GFAP STEAP3 LPCAT3 HEL-S-64p CP PMC7796775__F1 Steroidogenesis pathway in 21-hydroxylase deficiency HSD3B2 CYP21A2 STAR CYP17A1 CYP11B2 CYP11A1 HSD11B2 SULT2A1 PMC6700212__F1 Dual sequential cell death checkpoints in the TNFR1 signaling pathway RIPK3 TRADD MLKL RIPK1 TNF CYLD TRAF2 FADD PMC8350018__F3 Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway IGF1 GAS NFKB1 CTNNB1 PMC9561420__F2 Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response TBK1 IL10 TLR4 PDC IRF3 TRAF6 PMC321431__F10 Cascade of transcription factors that induce stress gene expression in response to eIF2A phosphorylation ATF3 ATF4 ATF2 PMC6507454__F5 Transcriptome analysis results of nuclear factor erythroid-2 related factor 2 knockdown BIRC7 MAFK JUND PXN RBCK1 DNTT ADD2 CNP PPP3CA GOLGA3 CTNNB1 PEX14 ADD1 SUMO2 NEUROG1 IL18 GADD45B ZBTB2 SH3GL1 AAG1 PSIP1 PHOX2A ZNF639 IL1B CEBPE POLR2C TREX2 EIF4B CAST FOSB PDE10A STK24 PICALM NCOR2 NR1C1 NR2A1 HEL23 MAFF CNOT3 FOSL1 OPRD1 YWHAZ NMT2 PMC7761500__F2 Various tumor-promoting mechanisms that can be exploited in combination with immune checkpoint inhibition IFNG STAT3 CXCR1 ELL IL8RB TWIST1 PMC7609165__F1 Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection TRIM16 ESX1 CGAS NR1C1 ATG16L1 TLR4 IRGM TFEB MTOR CLEC4E MYD88 PMC6402819__F5 R-loops drive DNA damage responses ATR ATRIP ATM SSB PMC9511979__F1 Relationships among microbiota, gastric cancer, and immunotherapy GSK3B SHH CTNNB1 PMC9511979__F2 Relationships among microbiota, gastric cancer, and immunotherapy IFNG ID2 APC UBA6 GC CTLA4 PMC7037737__F5 Interactions between the WNT pathway and aerobic glycolysis in exudative AMD HEL-S-133P APC GSK3B LRP5 LRP6 CTNNB1 PMC11216096__F2 Wnt signaling in gastric cancer: current progress and future prospects WNT10B ROR1 APC ROR2 LRP5 LRP6 TCF4 WNT2B CTNNB1 RNF43 WNT1 WNT3 WNT4 PMC11216096__F1 Wnt signaling in gastric cancer: current progress and future prospects APC ARHA RAC1 UNK CTNNB1 PMC9408922__F1 Biochemical Hazards during Three Phases of Assisted Reproductive Technology: Repercussions Associated with Epigenesis and Imprinting DHFR SLC19A1 PMC9696608__F1 Immunotherapeutic Implications of Toll-like Receptors Activation in Tumor Microenvironment TLR3 IRF3 TRAF3 MYD88 PMC2804071__F4 Joubert syndrome: insights into brain development, cilium biology and complex disease CEP290 RPGR PDGFRA ARL13B BBS4 SHH NPHP1 BBS1 CC2D2A LEF1 RPGRIP1L CTNNB1 PMC8602690__F2 Mechanism Actions of Astragaloside IV Prevents the Progression of Hypertensive Heart Disease Based on Network Pharmacology and Experimental Pharmacology RELA CHUK VEGFA TNF MPO PMC3585156__F5 Net Expression Inhibits the Growth of Pancreatic Ductal Adenocarcinoma Cell PL45 In Vitro and In Vivo CDK2 CDK4 PMC11119514__F1 RDNVs reverse osteoporosis by potentiating osteogenic differentiation of hBMSCs via targeting estrogen receptor A (ERA) signaling SMAD1 DKFZp781O1323 BMP2 RUNX2 PMC5061806__F2 Targeting mTOR for neurodegenerative disorders EGF TSC2 TSC1 EPO MTOR BDNF SIRT1 PMC8780245__F7 Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCB1 signaling pathway in diabetic atherosclerosis TIRAP RELA IRAK1 TRAF6 MYD88 PMC8496745__F1 How Oncogenic Viruses Exploit p62-Mediated Selective Autophagy for Cancer Development TBK1 CGAS RAD51 KEAP1 BRCA1 RNF168 ULK1 TRIM23 PMC1681476__F1 An SBGN process diagram (A) and a molecular interaction map (B) of a signaling pathway triggered by ligand binding to EGFR molecules EGF EGFR GRB2 SHE PMC4139479__F6 A Novel Mechanism of Skin Tumor Promotion Involving Interferon-gamma (IFNG)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling IFNG IFNGR1 JAK1 PMC5819891__F4 Homeostatic Systems, Biocybernetics, and Autonomic Neuroscience SPN NTS REST PMC8151764__F1 Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by Taxus Acyltransferases IPP HEL-S-5 PMC8591697__F2 Targeting regulatory T cells for immunotherapy in melanoma CD80 CD163 LAG3 PMC2417166__F8 Wnt signaling pathways in INS-1 cells EGF TCF7L2 GSK3B CTNNB1 PMC6114982__F8 Palbociclib resistance and MAP kinase pathway inhibition CDK6 CDK7 CDK2 MTOR KRAS CDK4 PMC11687129__F8 Mechanism of TAL in PD models TH RARA TRH DRD2 TRHR PMC7606110__F1 Current regulatory model of Wnt/Beta-catenin signaling, and the Wnt-targeting natural compounds which are currently under investigation CD44 BCL9 APC CTNNB1 PMC2423294__F8 The PKD1/class II HDAC/MEF2 signaling pathway in skeletal muscle PKD1 PMC8786725__F1 Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms TF CA12 EGR1 PMC8326751__F4 Combination of a Novel Genetic Variant in CFB Gene and a Pathogenic Variant in COL4A5 Gene in a Sibling Renal Disease: A Case Report HEL-S-62p C1S C1R PMC5068240__F10 Model illustrating the mode of action of RLTPR in T cells GRAP2 GRB2 PMC9035706__F1 Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling MTHFD2 PAICS MTHFD1 MTHFD1L SHMT1 HEL-S-51e PFAS ADSL PMC11040302__F1 Application of artificial hibernation technology in acute brain injury TLR4 CD163 RBM3 MYD88 PMC8437760__F2 Induced pluripotent stem cell-based disease modeling and prospective immune therapy for coronavirus disease 2019 SOX17 HOPX EGF MUC5AC SAG SOX9 SOX2 FOXP2 FOXA2 AQP5 CD34 PMC5338303__F2 Schemes of kinetic model used as a base for simulation of isotopologue distribution MAL PC CIT PMC9521683__F2 The POMC System on Glucose Homeostasis and Potential Therapeutic Targets for Obesity and Diabetes STAT3 PDE3B PLCG1 INSR FOXO1 LEPR TRPC5 ARC AgRP PMC6462321__F7 General summary of the NBP-involved cellular signal pathway in (a) cancer cell proliferation, migration, and apoptosis and in (b) stem cell differentiation BAX BCL2 MMP9 PMC3227667__F3 Genetic Signature of Spina Bifida Risk from Pathway-Informed Comprehensive Gene-Variant Analysis MTHFD2 MTFMT MTHFD1 DHFR AMT MTHFD1L SHMT1 HEL-S-70p HEL-S-51e PMC4700477__F10 Selected potential Rho GTPase functional networks identified in the RNAi screen CDC42 TRIO ROCK2 DOCK7 NCK1 ECT2 ARHA RHO RAC1 ARHGAP5 DOCK9 CYFIP1 CYFIP2 CDC42BPB ARHGEF7 PMC6121505__F2 Inhibition of apoptosis mediated by mFas and TRAIL EGF PI3 FADD PMC6121505__F3 Role of TLR3, 7 and 9 in SS TBK1 EGF TLR3 TLR9 IRF3 IRF7 TLR7 TRAF6 FADD MYD88 PMC10610100__F2 Protein–protein interaction (PPI) network map of the KEGG enriched signal pathway of differential genes VIP RGS2 RGS14 LCP2 HHIP PDE10A NR5A1 GPX3 FOS NR1C1 GUCY1A2 KPG_010 NPY PMC6691693__F2 Differentially expressed genes involved in cell cycle pathway DBF4 CDC20 PCNA ORC6 SMC3 SMAD4 MYT1 ORC3 SKP2 ORC2 CDK6 CDK7 E2F4 CDC45 CDK2 MDM2 CDK4 PMC5351557__F2 Yeast mitogen-activated protein kinase signaling pathway, illustrating the signaling paths in responses to different signals FAR1 MAK GLO1 PMC6859786__F1 NLR-dependent regulation of MHC class I antigen presentation NLRP3 NOD2 TAP1 NOD1 B2M IL1B PMC11877141__F0 Battling pain from osteoarthritis: causing novel cell death TF CGAS TRADD KEAP1 TXNIP GPX4 MLKL NACA2 DFNA5 MTOR MYC NOX4 CTNNB1 MYD88 GSDMD NLRP3 NQO1 RIPK1 ADORA2B PIEZO1 FOS SFRP1 RIPK3 TRPA1 STEAP3 ADAM10 HEL-S-64p TRAF2 SIRT1 FADD PMC9705310__F8 Schematic diagram of the proposed divergent effects of astrocyte-specific Cp knockout on learning and memory function TF BAX HP CP PMC11956203__F4 Key mechanisms of neuro-cancer crosstalk in HNC MMP7 S100A4 COX2 GAD1 MMP2 GLA GALR2 IL6 MMP9 ABCG2 CXCR4 PMC7085407__F3 PGC-1A signaling pathway in response to ROS/RNS TFAM SIRT3 PTEN SCO2 PMC6682711__F2 Autophagy signaling in HCC RHEB TSC2 TSC1 ULK1 PTEN CTNNB1 PMC8711784__F2 Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion TBK1 CGAS IRF3 PMC2887331__F2 Serine/threonine kinase Akt, also known as protein kinase B (PKB), has become a major focus of attention because of its critical regulatory role in diverse cellular processes, including cancer progression BAD PTEN HIF1A MTOR PMC7155254__F4 ERS and oxidative stress in patients with NAFLD and the generation and crosstalk of ROS signalling connecting these pathways CYP2E1 BCL2 ATF4 XBP1 APAF1 TRAF2 IRS1 PMC8711784__F1 Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion TBK1 STAT1 CGAS STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC6929077__F1 Nicotinamide (NAM) and Nicotinamide Adenine Dinucleotide (NAD+) metabolism NNMT NRK NAPRT HEL-S-90n NADK NAMPT PMC2921957__F4 Summary of factor H recognition functions and interactions CRP TH FH PMC11854763__F2 Signaling pathways directly and indirectly linked to RhoA/ROCK-mediated activation of GSK3B and the positive feedback loop between AB deposition and GSK3B activation ROCK2 ROCK1 BACE1 LRP6 APP PTEN ARHA SRC PMC8666288__F2 Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis DKFZp762B153 ATF4 MTOR UNK PMC7906326__F3 Current understanding of the interplays between host hormones and plant viral infections AGO1 CP PMC9200435__F3 Metabolic reprogramming in pancreatic adenocarcinoma (PDAC) ACLY HMGCR LDLR SOAT1 SLC7A5 ME1 KRAS PMC2857099__F6 Proposed model for NFKB repression by TRAF3 in LTBR activation LTBR TRAF3 TRAF2 PMC6002979__F1 B cell receptor signaling pathway CD40 TREM2 SYK BTK BCL10 BCR CARD11 BLNK CD19 LYN MTOR TRAF6 PMC3281723__F2 Role of PHLPP in terminating oncogenic signaling pathways PTEN MTOR PMC6002979__F2 Canonical and non-canonical NFKB signaling pathways LTA TLR4 RELB MTOR TRAF6 PMC8971810__F4 C1q/Tumor Necrosis Factor-Related Protein 9: Basics and Therapeutic Potentials CDH2 IFNG STAT3 TLR4 CD14 TRAF6 GATA4 MYD88 PMC3807240__F1 The NLRP3 inflammasome regulates the DNA damage response pathway OGG1 BIRC3 PMC3161973__F1 Putative mogrosides biosynthesis pathway in Siraitia grosvenorii MVD CS PMC7712090__F2 Analysis of miRNA Expression in Patients with Rheumatoid Arthritis during Olokizumab Treatment STAT3 JUN RAF1 SOS1 PTPN11 IL6 FOS IL6R HRAS CSNK2A1 IL6ST MAP2K1 GRB2 JAK1 PMC7500866__F1 Somatic Liver Knockout (SLiK): A quick and efficient way of generating liver-specific knockout mice using multiplex CRISPR/Cas9 gene editing HPD HPDL SLK PMC3003974__F3 Protein interaction network of highly connected proteins associated with the cardiorenal syndrome PPARG EGF ATR NCF2 EGFR PIK3CD NCF4 INS FOS MAPK14 EPHB2 PRKCE RELA EDNRA EDNRB IL6ST CYBA SRC CEBPB ACE2 PMC4695871__F2 Binding of the Hedgehog ligand (SHH) to Patched (PTCH1) removes the inhibitory signal for the G-protein-coupled receptor, Smoothened (SMO), causing translocation of the GLI1 and GLI2 transcription factors into the nucleus PTCH1 SHH SMO PMC8016706__F2 Growth and stress signalling pathways dictate responsiveness to stimuli and are hijacked in skin malignancy BAX EGF TIMP3 EGFR RELB MYC COX2 RELA BCL2 WNT4 MDM2 EDAR CCND1 HES1 TNLG7C PMC7415804__F1 Canonical Type I IFN signaling activated by DNA virus and RNA virus TBK1 CGAS TIRAP MAVS STAT2 TLR9 IRAK1 IRF3 TRAF6 MYD88 IFNG STAT1 TRIM25 TLR3 IFNAR2 IFNAR1 TRAF5 TLR7 JAK1 TRAF2 TYK2 PMC9108753__F10 scEFSC: Accurate single-cell RNA-seq data analysis via ensemble consensus clustering based on multiple feature selections TH ROCK2 ECD LAT MAK APC RYK GDA POR BAMBI IL25 SOST C13orf34 CBY1 SKP1 HEL-S-11 TOX NLK PMC7415804__F2 Mechanisms of actions of lncRNAs in regulating innate antiviral response TBK1 CGAS MAVS STAT2 SFPQ IRF3 GPR55 STAT1 TRIM25 TLR3 IFNAR2 IFNAR1 TYK2 PMC5725130__F3 Identification of hub genes related to silicone-induced immune response in rats CD40 IL19 TIRAP HEL-S-62p APC CTSK TLR9 CD14 CS IL6 RAC1 BCR KEL LBP FADD PMC10232107__F2 Compound-gene targets-signaling pathway network of the eight phytochemicals related to neuroinflammation PPARG CASP3 SRC TNF PMC5768609__F1 Schematic diagram depicting the role of miR-27a in Mycobacterium avium subspecies paratuberculosis (MAP)-mediated signaling pathways in macrophage TES TLR1 MAP3K7IP1 TLR4 IL1B PMC2910789__F1 Selected IGF-axis genes that encode core components of IGF-axis upstream the PI3K/AKT/mTOR and RAS/MAPK/ERK pathway IGF1 IGFBP5 IGFBP1 IRS4 IGF1R MTOR IGF2 IRS1 PMC8050094__F6 Intracellular Ca2+ cycling LPA HEL-S-11 PMC6940904__F1 Overview of the complement cascade and principal complement targeting molecules C6 CD59 FH C7 HEL-S-62p MBP C9 C4B_2 CR1 PMC8868096__F2 Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia HMOX1 KEAP1 NQO1 SFN PMC3347452__F7 Proposed model of SubAB-induced PERK-mediated apoptosis signaling pathway in HeLa cells BAX ATF4 EIF2A PMC3380363__F1 Oncogenic signaling pathways regulated by NO and PP2A EGFR SRC CTNNB1 PMC3703147__F1 Ubiquitination-mediated regulation of interferon responses STAT1 STAT2 PMC7752511__F1 Oxidative Stress, Nutrition and Cancer: Friends or Foes? CD24 FGF21 BMP4 BMP2 MSC FGF10 CD34 PMC8846937__F1 Pathophysiology of stress granules: An emerging link to diseases (Review) FUS TIA1 PMC7549330__F7 Diagram illustrating the molecular mechanism of LINC01315 in proliferation, invasion, and migration of OSCC cells PMC6588869__F1 Monolignol and ethylene biosynthesis pathways CAD JCAD PMC7560080__F3 ROS and low-molecular-weight hyaluronic acid (LMWHA) involvement in both priming and activation of the NLRP3 inflammasome CD44 NLRP3 MYD88 PMC8621356__F3 Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach RHEB TSC2 TSC1 PTEN PDK2 MTOR IRS1 EIF4E PMC8621356__F2 Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach TSC2 BAD TSC1 FOXO1 PTEN MTOR PMC10815772__F1 FGF/FGFR and downstream signaling pathway FRS2 GRB2 MTOR PMC10815772__F2 Molecular Targeting of the Fibroblast Growth Factor Receptor Pathway across Various Cancers FRS2 KIT FGFR3 GRB2 MTOR RET PMC5990418__F3A Getting the “kill” into “shock and kill”: strategies to eliminate latent HIV BAD FOXO1 PTEN PMC4347898__F5 Phosphortlated Smad3 is stabilized by ERG in prostate cells SMAD2 ERG PMC7581496__F8 FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential LATS1 CDC42 LATS2 RHO GRB2 MYC FGF18 YAP1 FGFR2 PMC1236692__F3 Caspase signaling and its modulation GAS2 PMC12116916__F8 TLR4 signaling modes and outcomes TBK1 SYK PLCG2 TLR4 MAL RIPK1 MYD88 PMC8044766__F1 Thrombotic and thrombolytic cascades and primordial immune response VWF SERP1 PLG A2M PMC7260648__F1 Mechanisms underlying cytoplasmic organellar dysfunction after chemotherapy and melatonin's protective effects under these conditions SIRT3 IL1B PMC6319725__F9 Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells SMAD1 NAMPT FADD PMC6319725__F8 Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells SP1 SIK3 MYBBP1A NAMPT FGF18 HIRA FADD ADA PMC7539774__F6 Schematic diagram of HP-based regulation in breast cancer glycolytic signaling pathway HEL-S-133P PFKP HEL-S-30 PMC10751872__F3 Advances in Regulating Cellular Behavior Using Micropatterns LATS1 LATS2 BMP2 PMC3824073__F2 Outline of the Crosstalk between p53 Family Members and the mTORC1 Pathwayp53 and p63 act upstream of mTORC1 and inhibit mTORC1 activity via multiple transcriptional targets RHEB TSC2 TSC1 IGF1 PLK2 PTEN PMC9266763__F2 Revisiting Regulated Cell Death Responses in Viral Infections RIPK3 HMGB1 GSDMD NLRP3 IL18 RIPK1 TRAF3 CYLD TRAF2 PMC9266763__F4 Revisiting Regulated Cell Death Responses in Viral Infections CRP TMPRSS2 BAX PRG3 MMP25 TRADD STAT2 MLKL RIPK3 NLRP1 GSDMD JAK1 TYK2 ACE2 LBP FADD PMC4991322__F1 The conserved pathway of sterol synthesis, storage and transformation in C DIO1 ENO1 IDI1 ATF2 PMC9289199__F2 Hepatoprotective and Hepatotoxic Roles of Sex and Sex-Related Hormones PRLR HMGCR IGF1 CRTC2 LDLR FSHR PMC3891587__F2 GENETIC CONTROL OF CANDIDA ALBICANS BIOFILM DEVELOPMENT NUP85 NRG1 PES1 ECE1 GHB3 ACE2 ADH5 PMC2999593__F1 Heme Biosynthetic Pathway CPO UROD UROS PMC6192719__F5 Deduction of novel genes potentially involved in hypoxic AC16 human cardiomyocytes using next-generation sequencing and bioinformatics approaches MAPK1 MICU1 DMTN FBXO31 UTP18 NRP2 G0S2 SULF2 TNF SERPINB8 CTNNB1 SLC16A3 SEC22B MME SLC6A8 LAP3 APLN BCL2 HDAC11 ApoL6 STC1 PMC8004672__F7 Correlation between growth factor signaling, the actin cytoskeleton, and CCN2 expression in CHs TGFA IGF1 CTGF RAC1 PMC3766629__F6 Immunohistochemical Staining, Laser Capture Microdissection and FASP Assisted Proteomic Analysis of Target Cell Populations within Tissue Samples CDC42 CALD1 HEL-S-273 HSPG2 ATP2A2 NUP62 HEL114 LIPC CAPNS1 COL1A1 PIG59 MUC5B CLU PLEC RAP1A HEL-S-108 C4B_2 PIGR RDX TRAM2 PMC3823507__F1 Post-translational regulation of iron homeostasis STEAP3 SMAD4 HAMP HFE PMC5527460__F1 KRAS‐dependent genetic network analysis RAD18 VPS28 RPS16 ELF4 DENR TPM3 ATM DHPS BNC1 NKD1 UBC BASP1 RAD51 ELP2 FEN1 MPHOSPH10 VMP1 KRAS ORC2 PHB2 BRCA1 NAB1 HEL-S-49 UBXN7 MMD PMC4075245__F1 Simplified schema showing how genes might affect clinical responses to targeted therapies BLK CD40 PTPN22 CD244 PADI4 CCR6 STAT4 TRAF1 IL6ST CTLA4 TNF PMC4657846__F6 Sites of complement pathway dysregulation HEL-S-62p CFI CFH PMC3899800__F2 BRCA1 and its toolbox for the maintenance of genome integrity RNF168 H2AX RNF8 PMC3899800__F3 BRCA1 and its toolbox for the maintenance of genome integrity FANCD2 RAD51 PMC10531820__F6 Regulatory T Cells in Cancer Treatment Resistance PTEN MTOR PMC6901085__F1 Representation of AKT pathway and downstream effectors BAX BAD PTEN MTOR IRS1 EIF4E PRR5 RHEB MLST8 TSC2 RICTOR TSC1 MDM2 GRB2 GAB2 CCND1 PMC8833603__F4 Protein Disulfide Isomerase in Breast Cancer ATF4 EIF2A PMC2577137__F1 Cross talk between PKA, PI3K/AKT and WNT/CTNNB1 intracellular signaling pathways IGF1 FOXO1 PTEN IGF1R MTOR FSHR CTNNB1 PMC7843555__F1 Five domains of T-cell dysfunction CD80 TIGIT FAS BTLA YY1 CTLA4 LAG3 PMC2776679__F7 Egr-1 and Hipk2 are required for the TrkA to p75NTR switch that occurs downstream of IGF1-R EGR1 IGF1 HIPK2 PTEN IGF1R PMC4657846__F1 Normal complement cascade C6 C7 HEL-S-62p C2 C1S C1R C9 PMC4816186__F6 Notch 1 signaling pathway and proposed mechanism of action of CJ BAX NFKB2 ADAM10 ERO1A MYC PMC9267699__F2 New Avenues of Heme Synthesis Regulation HMBS TH CPOX FECH UROD UROS PMC4657846__F2 Normal regulation of the complement AP HEL-S-62p CFI CFH PMC4463661__F1 Biochemistry of hydrogen production in Synechocystis PCC 6803 by direct biophotolysis TH CYB PC SI PMC5392381__F2 Central BCR signaling network constructed from literature SYK BTK BCL10 BCR PLCG2 CARD11 BLNK CD19 PTEN LYN PMC6473547__F5 Vitamins on Alzheimer’s disease CDK5 ADAM10 PMC6989314__F4 Pathway mechanism of the cell cycle CDK7 PCNA SMC3 CDK2 MYT1 SKP2 PMC7057654__F2 Vaccinations can inhibit the release of various pro-tumor cytokines WT1 ARF6 KRAS PMC2600644__F4 Pathway schematic of significantly regulated genes in (A) NFKB signalling and (B) MAP kinase signalling HEL-S-31 CDC42 DUSP5 TRAF3IP2 TRADD TNFAIP3 TNFRSF10B MAP3K12 TNFRSF1A TRAIP MAP4K2 TRAF3 TRAF6 MAP3K14 TNFRSF10A MAPK6 MAPK3 TNFRSF8 MAPK14 MAP3K2 TRAF4 MAP3K8 MBIP MAP2K6 TICAM1 NFKBIE ADORA2B DUSP8 JUN MAP4K1 TNFRSF9 FOS NFKBIL1 TLR1 NFKB1 ADRB2 NFKBIA TRAF5 TRAF1 EDARADD PMC3328839__F6 Proposed pathway TF ORAI1 STIM1 MTOR EIF4E PMC7827439__F3 Cytokine-mediated immune–epithelial crosstalk in inflammatory bowel diseases TH OSM APC IL33 TNF PMC5737637__F6 NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism ME3 SLC25A11 SLC25A1 ME1 HEL-S-26 NNT PMC7327232__F4 Membrane receptors on parietal and enterochromaffin-like (ECL) cells and intracellular signaling pathways that regulate gastric acid secretion CASR EGF TGFA EGFR PMC5357762__F1 Canonical and non-canonical Wnt signaling JUN FBXW7 RNF4 APC ZNRF3 CDK14 ARHA DAAM1 CTNNB1 PMC5737637__F2 NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism NRK NAPRT HEL-S-90n NADK NAMPT PMC5357762__F2 Mutation rates of Wnt pathway components in selected cancer entities TCF7L2 FBXW7 RNF43 APC GSK3B AXIN1 LRP6 GPR49 CTNNB1 PMC4910040__F1 mTOR signaling pathway RHEB EEF2K TSC2 TSC1 EEF2 RHO EIF4E PMC6251962__F1 Innate immunity and adaptive immunity IL25 TSLP IL33 TLR9 CXCL8 PMC3943178__F3 Coordination of macrophage-mediated signaling and muscle regeneration KLF4 IFNG SMAD2 TNF PMC11016796__F2 Proteomic analyses on chicken breast meat with white striping myopathy BAG2 PINK1 CDKN1A PARK2 MDM2 PMC5868586__F7 Schematic illustration of the underlying mechanism of L61H46’s anticancer activity.Abbreviations: IFN, interferon; IL, interleukin STAT3 STAT1 STAT2 JAK1 PMC3188673__F5 Vitamin D Metabolism and Function in the Skin DKK1 APC GSK3B CCND1 PMC8761221__F1 Autophagy regulatory pathways TSC2 TSC1 IL3 ULK1 MTOR ULK2 PMC2919366__F4 STAT3 signaling pathway IFNG STAT3 SOCS3 PMC4224557__F8 Postulated molecular regulation of eukaryotic elongation factor-2 kinase (eEF-2K)/TG2 pathway to the invasion-promoting signalling in pancreatic cancer (PaCa) cells SRC PMC4600531__F1 Wnt Signaling in Bone and Muscle APC ARHA RAC1 PMC8422159__F12 Enhanced Expression of miR-34a Enhances Escherichia coli Lipopolysaccharide-Mediated Endometritis by Targeting LGR4 to Activate the NFKB Pathway TLR4 TNF MYD88 PMC5234110__F7 Schematic representation of the suggested dynamic effects of PGE2 on naïve and primed microglia COX2 TLR4 TNF PMC8141399__F1 Banxia Xiexin Decoction Inhibits the Expression of PD-L1 Through Multi-Target and Multi-Pathway Regulation of Major Oncogenes in Gastric Cancer IFNG EGF TIRAP EGFR PTEN MTOR TRAF6 MYD88 PMC11616203__F3 Effect of TRPM channels on signal pathways related to tumor progression TRPM7 PCNA EGFR TRPM1 PTEN HIF1A MTOR TRPM8 CTNNB1 TRPM2 CCNE1 CDK2 MDM2 PMC2171731__F9 Invadopodium formation CDC42 EGF NCK1 PMC8242249__F6 Comparative Analysis of Coronavirus Nucleocapsid (N) Proteins Reveals the SADS-CoV N Protein Antagonizes IFNB Production by Inducing Ubiquitination of RIG-I TBK1 RNF125 MAVS TRIM25 IRF3 TRAF3 PMC7696523__F1 Canonical Hedgehog signaling in Basal Cell Carcinoma PTCH2 SUFU SMO PMC12206634__F10 The diverse intestinal innate immune pathway responses induced by non-S INDEL and S INDEL PEDV strain in weaned (A) and suckling (B) piglets ADAR MAVS NLRP3 TRIM25 MX2 MX1 IRF7 TRAF3 ISG15 TRAF2 PMC7963165__F1 Upstream mediators of TXNIP signaling TXN GSDMD ATF5 NLRP3 TXNIP TLR4 PTEN MYD88 PMC5522257__F3 Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer GSK3B DNM3 VAV1 RAC1 PMC7757414__F1 Targeted therapies available and in development in Acute Myeloid Leukemia (AML) FLT3 BCOR IRAK1 KIT EZH2 MTOR IRAK4 TEC CD33 BCL2 SMO CXCR4 HEL-S-26 CDK9 PMC8224798__F2 Harnessing the Physiological Functions of Cellular Prion Protein in the Kidneys: Applications for Treating Renal Diseases TF ARHA MTOR PMC5355992__F9 Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo TLR4 TRAF6 MYD88 PMC8472231__F7 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells PYCARD EPHA2 PML IFIT2 CCL2 NCAM1 F2R SP100 OSMR TLR4 MX1 CYBA ISG15 OAS1 GHR OAS2 IL12A CD14 IRF1 ANXA1 IRF7 GBP1 SDC1 XAF1 FOS HLA-DQB1 SPP1 CD44 LYN TWIST1 PMC8472231__F8 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells CDC42 CRK BAD VASP HEL-S-28 PTEN RHO GRB2 SHE PMC8472231__F9 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells MME TRADD ITCH C2 CASP3 NOD2 MMP3 TRAF3 TNF TRAF2 FADD PMC2920345__F3 Viral tricks to grid-lock the type I interferon system STAT1 STAT2 IRF9 FEV JAK1 INS TYK2 PMC1312313__F8 NO• regulation of the cell cycle CDC2 CDK6 CDC20 CDC6 CDK2 CDC25B CDK4 PMC8472231__F6 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells KRT18 EPHA2 HLA-DRB1 HLA-DQA1 CD14 IRF1 HLA-DPB1 IRF7 FOS HLA-DQB1 CD44 HLA-DRA CD74 FGFR1 LYN GHR BIRC3 PMC12049846__F7 Mechanisms DCSTAMP MAGI1 ROCK1 CTSK NFATC1 ARHA ACP5 PMC5446554__F1 Highly simplified overview of various functions of the mitochondrion, adjusted to highlight the steps catalyzed by enzymes for which the respective encoding genes were studied in this work GCSH OGDH PMC5384497__F1 Schematic view of the anti-inflammatory roles of SLPI in obesity-related atherosclerosis pathway CSA2 SLPI TLR4 PMC6661007__F2 Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases ORAI1 STIM1 BRAF HIF1A VEGFA CCND1 PMC6661007__F3 Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases STAT3 CXCL12 NLRP3 CXCL1 CXCL10 PMC8617635__F9 Riboflavin as a Mucosal Adjuvant for Nasal Influenza Vaccine CD40 CD69 CCR7 UNK PMC9170998__F3 Traditional Uses, Phytochemistry and Biological Activities of Alocasia Species: A Systematic Review APAF1 CDK4 PMC4496240__F7 Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways BAX SMAD1 DKFZp781O1323 BMP2 SMAD4 CDK2 GADD45A PMC11969448__F1 miRNA-dependent resistance mechanisms to anti-hormonal therapies in estrogen receptor-positive breast cancer patients TF CDC2 CDK6 EGFR APC GSK3B CDK2 BCL2 PTEN MTOR CDK4 CTNNB1 PMC12027374__F2 LH on spermatogenesis, LCs, and sperm cells HSD17B3 CYP17A1 CYP11A1 EGFR FSHR PMC12027374__F3 LH regulates testosterone synthesis in LCs through multiple pathways STAR FOXO3A EGFR PMC2291030__F3 EGF signaling pathway generated by the Ingenuity Pathway Analysis (IPA) software STAT3 EGF PLCG1 GRB2 PMC4919564__F1 Regulation of AMPK by metabolic stress, LKB1, and intracellular Ca++ TSC2 HMGCR MTOR NRF1 PMC6850886__F12 How PPM1H counteracts LRRK2 signaling pathway by dephosphorylating Rab proteins RAB43 VPS29 RAB10 VPS35 LRRK2 PPM1H RAB7L1 RAB35 PMC7407194__F1 Autophagic Machinery ATG101 ATG3 ATG16L1 ATG12 ULK1 UVRAG AMBRA1 ATG5 PMC7407194__F2 DSB repair RAD51 NHEJ1 H2AX BRCA2 ATM RIF1 BLM RBBP8 PMC4919564__F2 Representative signaling in the AMPK pathway by various AMPK activators ADIPOR1 ADIPOR2 MTOR SIRT1 PMC7407194__F3 Main pathways regulating the DDR-mediated autophagic response ATG101 TSC2 DDIT4 ULK1 UVRAG AMBRA1 RB1CC1 ATM PTEN DEPTOR PARP1 AATF PMC9116923__F3 Autophagy and Renal Fibrosis TSC2 GAL GABARAPL1 TSC1 ATG12 ULK1 BNIP3 BCL2 BNIP3L MTOR TNF ULK2 PMC3276397__F1 Effects of VitA in gut-associated lymphoid tissue RARA FOXP3 PMC10887144__F1 In vitro liver organoid model creation FGF7A EGF HGF OSM BMP4 STH PMC10648512__F3 Effect of exosomes derived from glioma stem cells and containing miR-26a on the BBB GSC PTEN MTOR PMC4410569__F7 HJV and HFE Play Distinct Roles in Regulating Hepcidin TFR2 HFE HFE2 PMC9662265__F1 Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion S1PR1 SOX6 TXNIP MSC PMC3688919__F8 microRNAs Involved in Regulating Spontaneous Recovery in Embolic Stroke Model STAT3 RECK HES3 SMAD2 APC LRP5 SMAD4 LRP6 PTEN MTOR COL1A1 CDKN1A SHH SMO WNT3 PMC7555132__F3 Cdc48-dependent MAD and mitochondrial quality control mechanisms UBR1 PINK1 MFN2 NDE1 HUWE1 PMC12162925__F7 Integrating transcriptomics and metabolomics data TG APOC1 HMGCR IMPACT PMC9675748__F6 Consequences of HDAC6 activity inhibition regulation through TubA treatment in DMD mice model MTOR HDAC6 PMC8383741__F7 IP-10 Promotes Latent HIV Infection in Resting Memory CD4+ T Cells via LIMK-Cofilin Pathway CDC42 CXCR3 LIMK1 CXCR4 PMC6881211__F9 Emerging roles of the long non-coding RNA 01296/microRNA-143-3p/MSI2 axis in development of thyroid cancer STAT3 MSI2 CCND1 PMC6514059__F2 Expression of the NCRs and their Ligands IL15 NID1 PCNA CFP IL2 PMC7467481__F1 Balance between thrombosis and bleeding in liver disease TFPI PLG ADAMTS13 PMC7175458__F4 Classic AHR signaling pathway AHR PAH AHRR PMC3356574__F3 The signaling pathways regulating radiation-induced bystander effects through expression and secretion of soluble biologically active factors STAT3 IGF1 COX2 IL33 ATM IGF1R IL6 TNF LEF1 PMC9333350__SF1 TLR9 signaling pathways UNC93B1 TLR9 IRAK1 IRF7 TRAF6 IRAK4 MYD88 PMC8065911__F7 Schematic diagram showing the effects of ABZ on STAT3/5 signaling pathway via modulating SHP-1 expression STAT3 JAK1 SRC CCND1 PMC5217513__F1 AXL structure and effector pathways.Notes: Shown are the primary structural determinants impacting AXL activation and signaling AXL SRC PMC8276817__F2 Molecular targets for FAK inhibitor combination therapy LATS1 ARHA CTNNB1 PMC3539509__F2 TLR4 signaling pathway: TLR4 is localized on cell surface for ligand recognition and activates both MyD88-dependent pathway and TRIF-dependent pathway TBK1 MAP3K7IP1 TLR4 MAL IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC2423434__F5 Dynamically asserted instances of interactions DDI1 APC CYP3A4 DDI2 PMC7309610__F2 Innate immune pattern recognition of bacterial lipids on OMVs leads to inflammation and death NLRP3 TIRAP TLR4 CD14 IRF3 LBP IL1B MYD88 PMC7296058__F4 G6PD in cancers BAG3 KEAP1 PAK4 PTEN HNRNPK ID1 CTNNB1 PMC10975841__F4 Dietary Factors on DNA Methylation Levels of TNF-Alpha Gene and Proteome Profiles in Obese Men RHEB TSC2 BAD BCR CD37 MEI1 RBL2 CD19 PTEN MDM2 RAC1 EIF4E PMC7296058__F1 Pentose phosphate pathway (PPP) HEL107 RPE PMC3436816__F2 EnrichNet: network-based gene set enrichment analysis MSH6 IF2B1 OSM LRRK2 EGFR APC CR2 PTEN IL22RA2 PPP2CA MINPP1 RB1 TPR TSC1 BCR IF2D AHR FLT1 SCRIB NF2 RET PMC7532093__F8 Protein-protein interaction network of hsa-miR-30a-5p-related DEGs GLDC TET2 HEL113 RECK PHACTR2 SIX4 E2F7 RNF26 RORA NCAM1 DCP2 FYN SLC30A2 EYA2 MAF RAB3D DMD CFL2 FZD2 OVOL2 PRSS21 LONRF1 CELF2 PITPNM2 CPEB4 CCNE2 FER EDNRA BCL2 HLF JAK1 CHKA PMC11855089__F8 Comprehensive analysis of metabolomics and network pharmacology H1-5 CYP2C9 H1-6 HIST1H1E IMPACT H1-3 H1-2 PMC7532093__F9 Protein-protein interaction network CXCL12 RFC1 STX6 CKS2 SEC22C KMT2A EREG MED29 APH1B YKT6 HEL-S-133P SSH2 MTA2 POLI NMNAT2 SMC1A HEL114 FMN1 FKBP4 MLLT3 VPS35 SEC22A FER PLAG1 CASP3 TP63 MSL2 PMC156764__F1 NEW EMBO MEMBER’S REVIEW TRADD RELA TRAF6 TNF CCND1 FADD MYD88 PMC7367602__F1 Microarray-based Analysis of Genes, Transcription Factors, and Epigenetic Modifications in Lung Cancer Exposed to Nitric Oxide PLN TRHDE GRAP HSF1 AATK KL PLP2 PMC7464161__F8 Possible mechanism of action of metformin and everolimus in QGP-1 and H727 cells TSC2 TSC1 IGF1 AIP MTOR IRS1 PMC7869416__F6 Schematic diagram illustrating Eif2s3y functions in goat SSCs NR1B3 GDNF PMC6358305__F1 Schematic biochemical pathway for the production of bioactive chemical mediators leukotriene C4 (LTC4) and leukotriene B4 (LTB4) LTB LTA PMC6358305__F2 Incorporation of arachidonic acid into membrane-bound phospholipids by the Lands pathway () TES ACAT1 LOX DGAT1 COX1 COX2 ACAT2 C2 DGAT2 PMC6837928__F1 Folate metabolism and interaction with other nutrients such as vitamin B12 and choline DHFR HEL-S-61p PMC4506441__F5 Distribution of target proteins on the compressed ‘influenza-related pathway’ CD40 PLN STAT3 EGFR GSK3B ELL UCP1 CHRM3 REN MME PLCG2 COX2 LNPEP MIP NOS2 PIM1 CPA3 PLG IRF3 CTSA IL6 NLN TRIM25 TLR3 CHRM2 CDK2 PMC7788045__F6 Schematic illustrating the Sirt1–FGF21 axis and vilda-mediated cardiac protection FGF21 DPP4 SIRT1 PMC314316__F1 Schematic model indicating the presence of two potential insulin receptor–dependent signal transduction pathways SNAP23 VAMP2 APC PMC7316884__F1 De novo ceramide synthesis pathway and its hormonal regulators in adipose tissue CERS3 CERS5 CERS1 TLR4 CERS2 KDSR TNF CERS6 PMC4860032__F1 The metabolism, analysis, and targeting of steroid hormones in breast and prostate cancer SRD5A2 CYP17A1 PMC3824660__F2 Interrelations between autophagy-related signaling and cell growth control in response to stress RHEB TSC2 TSC1 BNIP3 PTEN ATF4 MTOR EIF2A IRS1 PMC7796305__F3 Role of the Renin–Angiotensin–Aldosterone System in Dystrophin-Deficient Cardiomyopathy SMAD2 SMAD4 ACE2 PMC7796305__F2 Complex network of interplayed cellular and molecular mechanisms that participle in the development of myocardial fibrosis leading to the occurrence of dystrophin-deficient cardiomyopathy PI3 SMAD4 PMC6274739__F2 Basic TGFB signaling diagram along with a program of TGFBeta-regulated genes that contribute to the EMT CDH2 TRAF4 ESRP2 ESRP1 SMURF1 HAS2 ZEB2 ARHA RHO TRAF6 TWIST1 PMC5917448__F12 1-Deoxynojirimycin on gastric ulcer by affecting NFKB pathway COX1 COX2 TNF PMC3608642__F4 Multiple Single-Cell Genomes Provide Insight into Functions of Uncultured Deltaproteobacteria in the Human Oral Cavity POR TOX PMC8622657__F3 Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration CBL GRB2 PMC6023839__F5 Regulatory Network and Crosstalk Analysis for Gene Set(A) KEGG pathway network formed by relapse gene sets SCARB2 AURKA BET1 SMC3 DNTT EVI1 BNIP3 MED13L PPP3CA MYC PEX3 GNAS EZR WT1 GRB10 MME PLCL2 MEIS1 ZEB2 CACYBP SOX4 CEBPE OPA1 APC NOTCH2 DEPTOR NAIP ATF3 PIGA SCML2 MSANTD2 NRIP3 PRKAB1 CCL4 SMURF2 SDC2 LMNA DEPDC1 DUSP10 PLCB4 HMGA2 INHBC TGIF1 PTPN13 MPO HEL-S-308 ADCY9 YBX3 PBX3 NOD2 AHR AGA MED13 OAS2 MYBL1 CXADR JUP ACTN1 JUN TBL1X CXCL2 ORC2 PURA CPOX HCAR3 ITGAM SMURF1 LYN HSDL2 KAT2B PMC3549334__F7 Ras activation by •NO-mediated processes in pancreatic cancer HRAS RALB RALA PMC5559481__F1 LncRNAs serve as p53 regulators and effectors, participating in the p53 regulatory pathway PMC4855107__F1 Arachidonic acid (AA) metabolism involved in the pathogenic mechanisms of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity LTB LTA COX1 PMC6581604__F7 LMNA mechanosensing based on a ‘lose it or use it’ mechanism for tension-inhibited turnover that also applies to collagen-I MMP2 LMNA PMC9030951__F1 The Homeostatic Unfolded Protein Response in Diabetic Nephropathy BAX TXNIP APC ATF4 EIF2A XBP1 PMC4629125__F1 Intrahepatic interplays among hepatocytes, non-parenchymal cells (NPC) and lymphocytes and illustration of antiviral and immunotherapeutic strategies TBK1 IFNGR1 TIRAP IRF9 IRF3 ATF2 MYD88 IFNG IFNGR2 TLR3 IFNAR2 IFNAR1 JAK1 TYK2 PMC5659737__F1 Review of Markers of Zona Glomerulosa and Aldosterone-Producing Adenoma Cells TF TGFB1 CYP11B2 APC PTCH1 SHH SMO ARHA LEF1 CTNNB1 PMC4833509__F7 Two-Step Reactivation of Dormant Cones in Retinitis Pigmentosa RPE FAS TXNIP PMC5828779__F5 Toll-like receptor signaling pathways in the prefrontal cortex TBK1 CD14 IRAK1 IRF3 IRF7 TRAF3 CXCL10 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR7 PMC6581604__F1 Contractility or collagen perturbations result in rapid ~1h changes in LMNA, DNA damage, and cell cycle CTRL TH H2AX LMNA PMC7769821__F4 KEGG pathway schematic diagram of inflammatory bowel disease (IBD) IL3 APC LIF IL4 PMC9030951__F3 The Homeostatic Unfolded Protein Response in Diabetic Nephropathy APC XBP1 SIRT1 PMC7769821__F5 KEGG pathway schematic diagram of cytokine-cytokine receptor interaction LEP SLA PRL LIF PMC3031466__F10 A PtdIns(3)P-mediated signaling pathway that drives the degradation of apoptotic cells VPS29 SNX1 SNX6 PMC3383846__F2 Signaling pathways that regulate cytokine AREs post-transcriptionally HEL-S-76p IL16 TLR4 IL6 PMC5629024__F3 Gene networks with the genes in core from GSEA analysis USP44 KRT18 BACH2 IL18R1 TSHR PRDM1 CCR2 PHLDA1 CTNNB1 TXNRD3 PLAG1 MICAL2 ANGPTL7 APP TSPAN4 MAP2K2 DACH1 ZBED3 AHNAK CCR10 TOP2A PMC4003375__F1 Nck proteins as the newly identified adaptors between the BCR complex and BCAP/PI3K/Akt pathway SYK BAD BTK FOXO1 CD19 LYN GRB2 PMC8278735__F6 Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NFKB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation KEAP1 HEL-S-67p TLR4 IL6 IL1B MYD88 PMC3648215__F1 Androgen regulation of epithelial–mesenchymal transition in prostate tumorigenesis ARHA LEF1 CTNNB1 PMC8395114__F6 Clavibacter michiganensis Downregulates Photosynthesis and Modifies Monolignols Metabolism Revealing a Crosstalk with Tomato Immune Responses RPS2 MAPK7 PMC3641677__F4 Mechanisms that Regulate Stem Cell Aging and Life Span RHEB TSC2 TSC1 IGF1 PTEN IGF1R EIF4E PMC8787342__F1 Activated Macrophage – A Tough Fortress for Virus Invasion: How Viruses Strike Back CD80 CGAS MAVS TLR9 IRF3 IRF7 IL6 TNF CCL2 CXCL8 MYD88 TLR3 TLR4 TLR7 TRIM29 PMC3500850__F4 Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response HEL-S-133P HK2 GLRX HEL-75 PMC9306048__F7 Forkhead Box S1 mediates epithelial-mesenchymal transition through the Wnt/Beta-catenin signaling pathway to regulate colorectal cancer progression CDH2 MMP7 APC CTNNB1 PMC3679382__F8 Working model of the FGF21 regulatory pathway under leucine deprivation FAS FGF21 UCP1 ATF4 EIF2A PMC4040351__F2 From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling DLL4 GSK3B NOTCH2 MYC FBXW7 CCR7 JAG2 BCL2 NOTCH3 DLL3 CCND1 HES1 NOTCH1 PMC4040351__F4 From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling GSK3B PTEN MTOR HES1 CTNNB1 PMC7143722__F3 De-novo fatty acid synthesis in oleaginous microorganisms (adapted from [,,,,,]), and enzymes involved in lipid accumulation LPA FAS HEL-S-5 FADS2 PTH PMC5133788__F10 11-epi-SA-induced apoptotic pathway in HA22T cancer cells BAX JUN BAD ATF4 EIF2A TRAF2 PMC10037167__F1 Myostatin silencing inhibits podocyte apoptosis in membranous nephropathy through Smad3/PKA/NOX4 signaling pathway GDF8 NOX4 PMC8088836__F4 PH Regulation in the Tumor Microenvironment (TME) FOXM1 LDHD HIF1A MTOR VHL PMC3139433__F4 Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes RAF1 SMAD4 MYC FGFR2 HDAC3 RB1 YY2 FYN POMC POLR3B KDR GRIN1 SRC TRIO SERINC3 UGT1A10 ACIN1 VEGFA TNF FOS IRS1 HRAS UBE2V1 CDKN1A RXRA MAP3K7 GRB2 ZSCAN12 RABAC1 MAX TF BSN FAS MAPK11 BRAF CTNNB1 SUMO1 YEATS4 P2RY2 GAS1 TEF PPM1F JUN CDKL5 ZMIZ1 NRP2 FGF2 POLR3D HOXB7 PRKDC CHEK1 DDIT3 ERBB2 CHN1 LCK PMC5647233__F4 Hypothetical roles of ANTXR1 as a modulator of HbF expression HBG2 HBG1 HBD HBB HBE1 PMC8636224__F1 Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics CD81 CD9 EGFR ARF6 TSG101 CD63 PMC3206202__F10 Expression Profiling Reveals Differential Gene Induction Underlying Specific and Non-Specific Memory for Pheromones in Mice GAA GAL ELL PMC8870287__F2 Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity BAD IGF1 IGF1R MTOR PMC8036595__F7 Mg2+ and Gd3+ interfere with phosphate-induced SOCE upregulation by the activation of CaSR in megakaryocytes—a schematic representation CASR ORAI1 SGK1 STIM1 NFAT5 PMC11640972__F2 Tryptophan metabolic pathways HEL-S-90n KYNU KMO PMC4361250__F4 Hedgehog signaling in prostate epithelial-mesenchymal growth regulation SUFU PTCH1 SMO GLI3 PMC10451954__F1 Primary Coenzyme Q10 Deficiency: An Update COQ8B COQ10B COQ8A COQ10A COQ7 PDSS1 COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 PMC8220142__F4 Dual Characters of GH-IGF1 Signaling Pathways in Radiotherapy and Post-radiotherapy Repair of Cancers BAX IGF1 ATM IGF1R TRIM29 GHR PMC2951628__F1 Inflammation Joins the “Niche” TLR4 S100A8 S100A9 PMC7101072__F1 Research Priorities for Heart Failure with Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary NPPA NPPB PMC8895466__F1 Cell-based immunotherapy of glioblastoma multiforme CSF1 CXCR4 CSF1R PMC3874419__F1 Signaling cross-talk at the various levels of EGFR/HER2 signaling pathways MAPK1 EGFR PTEN MDM2 MTOR PMC8082181__F10 Trilobatin, a Component from Lithocarpus polystachyrus Rehd., Increases Longevity in C. elegans Through Activating SKN1/SIRT3/DAF16 Signaling Pathway SIRT3 PMC10722483__F6 Acupoint catgut embedding attenuates fibromyalgia pain through attenuation of TRPV1 signaling pathway in mouse TRPV1 MTOR PMC4443744__F5 Crosstalk between complement and TLR pathways TF TLR4 IL6 MYD88 PMC3512410__F2 Scheme depicting the different outcomes caused by the presence of progerin and prelamin in cells ATR RBBP4 ATM RUNX2 CTNNB1 PMC9509045__F5 Bioinformatic identification of differentially expressed genes associated with hepatocellular carcinoma prognosis DBF4 PCNA CDC6 SMAD2 SMC3 GSK3B CD14 SMAD4 ORC1L MYT1 PLK1 ORC3 SKP2 ORC2 E2F4 CDC45 CDK2 MDM2 PMC10534805__F9 Lonicera Caerulea Juice Alleviates Alcoholic Liver Disease by Regulating Intestinal Flora and the FXR-FGF15 Signaling Pathway TG NR1C1 CYP7A1 MUC2 MUC4 PMC9262551__F3 Relevance of NLRP3 Inflammasome-Related Pathways in the Pathology of Diabetic Wound Healing and Possible Therapeutic Targets NLRP3 TXNIP MTOR PMC8268744__F1 Structural and Drug Targeting Insights on Mutant p53 ATR FAS DDR1 SLC2A4 PML SFN TIGAR GPX1 FANCC BIRC5 BCL2L1 ATM SCO2 MDM2 CCNB1 AIFM1 APAF1 CDC2 BAX MSH2 VEGFA XPC DRAM1 DDB2 CDKN1A BCL2 GLS2 CXCR4 GADD45A PMC4533861__F7 CX3CL1-induced breast carcinogenesis in ErbB2 transgenic mice HBEGF C2 CX3CR1 CX3CL1 PMC11019510__F5 Role and mechanism of TXNDC5 in disease progression PMC4325379__F1 An overview of melanocyte development DCT KIT TYRP1 SOX10 PMC9131939__F14 Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach RHEB STAT3 BAX ATR ATM PTEN HIF1A PMC6030854__F1 The effects of the Insulin-like Growth Factor 1 (IGF-1) on muscle growth and homeostasis IGF1 IGF1R DEPTOR PMC7991804__F2 An overview of mechanisms of GC resistance in ALL and pharmacological strategies to overcome it FLT3 SGK1 GC BCL2 PTEN MTOR HES1 CRLF2 NR3C1 PMC8115323__F1 WNK-SPAK-NCC pathway and WNK ubiquitination by the CUL3-KLHL3 E3 ubiquitin ligase complex WNK1 WNK4 KLHL3 OSR1 PMC3881016__F5 Pathway analysis of iron deficiency associated chlorosis IDI2 COMP ID2 PMC8032689__F10 The MAF-TGFB1-crystallin axis that underlies the pathological growth of lens in high myopia SMAD2 MAF SMAD4 PMC6472122__F5 Transfer RNA-derived fragment target genes in the Kyoto Encyclopedia of Genes and Genomes AMPK pathway map generated using DAVID software FAS CD36 MTOR PDK2 INS RHEB TSC2 TSC1 NR2A1 IGF1 INSR F2 CFTR PMC8825743__F3 Notch signaling in the pathogenesis, progression and identification of potential targets for cholangiocarcinoma (Review) LTBR EPHA2 MTOR PMC3208056__F4 Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/Beta-catenin/cyclin D1 signaling pathway in rats COX2 APC BCL2 CTNNB1 PMC8351444__F7 MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies MAX ELF4 SYK BCR SRC MYC PMC3959161__F2 Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity LPL TG FAS DGAT1 GC PCK1 PMC3255319__F1 Oncogenic and tumor suppressor control of metabolism ACLY PRM2 FH HEL-S-133P HK2 FASN PTEN MTOR VHL AGER NF1 PHGDH HEL-S-26 PMC3260854__F6 FosB-mediated regulation of ECM genes by mechanical signaling in bladder smooth muscle TNC JUN FOSB PMC5870354__F2 SignalingEpithelial growth factor receptor signal transduction STAT3 STAT1 EGF PLCG1 EGFR GRB2 MTOR JAK1 PMC6213175__F3 Select HCMV gene products that target apoptotic pathways during HCMV infection BAX MTOR FADD PMC4028977__F1 Targeting inflammation: multiple innovative ways to reduce prostaglandin E2 COX1 PMC2674743__F2 Altered insulin signaling by lipid intermediates FAS MTOR PMC9100777__F1 Bilayer Forming Phospholipids as Targets for Cancer Therapy PTDSS2 SELENOI PTDSS1 PEMT PC PCYT2 PISD PMC4340906__F5 Induction of Indoleamine 2, 3-Dioxygenase in Human Dendritic Cells by a Cholera Toxin B Subunit—Proinsulin Vaccine STAT1 JUN UBC TYROBP IDO1 NFKB1 NFKB2 AHR EZH2 SLC7A11 COMMD1 PMC8204302__F7 Host determinants of disease severity in acute cystitis; mechanism of IL-1B and SP hyperactivation MMP7 C6 NLRP3 TIRAP TLR4 IL1B MYD88 PMC4622840__F1 c-Met-mediated oncogenic signaling (from Peruzzi et al) HGF GRB2 IMPACT PMC6093675__F6 Striatal transcriptome of a mouse model of ADHD reveals a pattern of synaptic remodeling DPYSL5 CTNNBIP1 GSK3B AMOTL2 CTNNB1 PMC8508740__F1 New Fast Acting Glucagon for Recovery from Hypoglycemia, a Life-Threatening Situation: Nasal Powder and Injected Stable Solutions PIGA PYGB PMC6236198__F6 Cell cycle pathway (the chart is from the KEGG database, gene symbolized by ★ and correlation P values can be found in ) CDC20 CDK7 PCNA CDC45 SMAD2 SMC3 SMAD4 CDK2 MDM2 MYT1 SKP2 ORC2 PMC3412962__F4 A, Differential expression of proteins involved in glycolysis and TCA cycle DLAT HEL-S-133P LDHD LDHB PLAA PMC9282876__F7 Sanguinarine Regulates Tumor-Associated Macrophages to Prevent Lung Cancer Angiogenesis Through the WNT/Beta-Catenin Pathway WNT10B APC LRP5 WNT7A WNT1 LRP6 WNT7B CTNNB1 PMC8622894__F2 Plasma Ceramides Pathophysiology, Measurements, Challenges, and Opportunities CERT1 CERK SMS tmp_locus_29 SMPD1 SMPD2 PMC1069556__F6 Effect of NS5A on the Beta-catenin signaling pathway BAD GSK3B TEF CTNNB1 PMC8081964__F3 MicroRNA Expression Changes and Integrated Pathways Associated With Poor Outcome in Canine Osteosarcoma NUMB IGF1R PARP1 CTNNB1 CD44 RB1 CDKN1A NFKB1 ERBB2 LFNG SMO CCND1 HES1 NOTCH1 PMC4097927__F4 Polyamidoamine dendrimer-based gene delivery vectors DCC HEL-S-62p NHS C2 C1S CS PMC7689704__F8 Pipoxolan suppresses the inflammatory factors of NF‐KB, AP‐1, and STATs, but activates the antioxidative factor Nrf2 in LPS‐stimulated RAW 264.7 murine macrophage cells STAT3 STAT1 TIRAP TLR4 CD14 JAK1 FOS LBP MYD88 PMC4019579__F8 NAMPT-Mediated Salvage Synthesis of NAD+ Controls Morphofunctional Changes of Macrophages CDC42 LIMK2 TLR4 NAMPT ARHA RHO PMC3667651__F3 Mechanisms underlying molecularly targeted therapeutics-induced cardiac toxicity NRG1 SRC PMC7407594__F2 RNA sensing mechanisms RAF3 TLR3 RNASET2 IFIT1 TLR8 RNASEL IRF3 TLR7 OAS1 MYD88 PMC7407594__F4 Posttranscriptional mechanisms by RNA-binding proteins (RBPs) regulating mRNA stability DCP2 ARID5A BCL10 N4BP1 EDC4 TLR4 CARD11 PMC6108877__F7 Schematic representation of the anti-invasive effects of wogonin in LPS-stimulated MDA-MB-231 cells, via the 5-LO/BLT2 pathway LTB TLR4 MYD88 PMC6329798__F1 ABPs used for caspase analysis CASP9 CASP8 BCL2 CASP10 PMC7142844__F8 Molecular mechanisms of SNRPG-mediated p53 targeting of TMZ-induced glioblastoma multiforme (GBM) growth inhibition SNRPG CDK2 CCNB1 MGMT PMC2881215__F1 Signaling in podocyte apoptosis GDNF CD2AP NOTCH1 PMC7920062__F1 Bile acid metabolism CYP7A1 CYP46A1 CYP27A1 PMC7757049__F3 miR-340 is associated with various genes modulating cancer cell proliferation CCNG2 BMP4 FHL2 JAK1 SKP2 GPR49 CDK4 CTNNB1 PMC6030169__F1 Intracellular exposure to intermediate ROS levels triggers conformational changes in KEAP1 via oxidation of its C-terminal cysteines, resulting in dissociation of the KEAP1-NRF2 complex and subsequent nuclear translocation of NRF2 MAX KEAP1 PGAM5 AIFM1 PMC7757049__F4 miR-340 is involved in the regulation of cancer cell apoptosis STAT3 BAG3 SOCS3 CTNNB1 PMC5788694__F4 Role of ginsenosides in reactive oxygen species-mediated anticancer therapy ATG3 NR3A2 MTOR ATG5 NCF1 CYBB PMC7139912__F2 Symplified representation of pro-inflammatory mediators in Wobbler (Wr) mouse spinal cord HMGB1 NLRP3 IL16 TLR4 IL18 MYD88 PMC5010532__F1 Adaptive UPR in Parkinson׳s disease ATF4 EIF2A BDNF XBP1 PMC10622988__F4 Tumor-associated signaling pathways influenced by lncRNA SOX21-AS1 in breast cancer, lung adenocarcinoma, and glioma LATS2 WWC1 TSPAN8 NF2 CCND1 CTNNB1 PMC8996999__F1 Posttranslational Modifications in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, Classification, and Treatment TIMP3 TGFB1 TSHR FOXO3A TPO HIF1A VEGFA SLC5A8 PMC8996999__F2 Posttranslational Modifications in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, Classification, and Treatment FOXO3A GSK3B PTEN MTOR CTNNB1 PMC6715251__F9 Adenovirus early region 3 RIDA protein limits NFKB signaling through stress-activated EGF receptors RILP EGFR PIN1 PMC7432451__F1 ITAM- and ITIM-signaling receptors sense the microenvironment and determine the response of microglia TREM2 TYROBP NLRP3 SIRPB1 SIRPA SRC IL1B PMC7818015__F4 DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy RAD51C ALKBH3 RNF113A PMC4427577__F1 Signaling by TGFB family members through the Smad-dependent and Smad-independent pathways: TGFB induces its response by multimerization of TGFB receptor II (TBRII) and TGFB receptor I (TBRI) MAP3K7IP1 SMAD4 PMC6821048__F7 Inhibitory effects of butein on cell proliferation and TNF-Alpha-induced CCL2 release in racially different triple negative breast cancer cells CASP8 TRADD IKBKE CASP3 CASP10 TRAF2 FADD PMC5473901__F8 Summary Effect of miR34a BCL2 PMC4803799__F3 mTOR in sensing autophagy signals : mTOR inhibition integrates amino acid starvation, growth factor deprivation, decreased ATP or oxygen levels, enhanced reactive oxygen species (ROS) to activate autophagy RHEB TSC2 TSC1 ULK1 TFEB BNIP3 HIF1A PMC4443744__F2 Role of complement in physiology FH HEL-S-162eP IL33 CTSL MTOR CR1 PMC4803799__F7 Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches PINK1 FIS1 TOM7 MFN1 BAG4 BNIP3 FUNDC1 TRAF6 USP30 SMURF1 USP15 SARM1 PARL AMBRA1 FBXO7 CHDH PMC8464934__F2 Glutathione Metabolism in Plants under Stress: Beyond Reactive Oxygen Species Detoxification CD2 C7orf24 PMC3776718__F3 Overlay of the insulin-like growth factor-1 (IGF-1) signaling pathway with microarray data for comparison of very small embryonic-like stem cells (VSELs) with hematopoietic stem cells (HSCs) STAT3 BAD NEDD4 IGF1 IGF1R SOCS3 GRB2 PMC7545020__F2 An aberrant STAT pathway is central to COVID-19 STAT1 STAT2 IRF9 JAK1 TYK2 PMC7545020__F3 An aberrant STAT pathway is central to COVID-19 STAT3 EGF EGFR PIAS1 SOCS3 JAK1 SRC TYK2 PMC7545020__F4 An aberrant STAT pathway is central to COVID-19 CRP STAT3 STAT1 TLR4 HAS2 PMC5300050__F3 Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly RPS6 SYK CD36 PMC7770133__F2 Summary of reverse MHC-I signaling pathways in various cell types STAT3 ZAP70 BAD B2M MTOR ARHA TRAF6 SKI MYD88 MMP2 SRC REL TYK2 LCK IL1B PMC8869911__F4 Dissecting Tumor Growth: The Role of Cancer Stem Cells in Drug Resistance and Recurrence GSK3B SMO CCND1 CTNNB1 PMC9454566__F9 Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response CCRL2 SLA CMKLR1 POGZ IRF9 IFITM1 IRF7 OAS3 SAMD9 MX1 ISG15 OAS1 OAS2 PMC8968815__F1 Wnt/Beta-catenin signaling pathway related microRNAs in esophageal cancer STAT3 DKK3 SFRP4 GSK3B DACT3 ZNRF3 CDK2 DKK2 CTNNB1 PMC7765095__F2 KEGG GO pathways of selected apple Full-length cDNA OvereXpressing (FOX) Arabidopsis mutant lines CRYZ MAK CRY1 ELF3 PMC3829661__F2 Schematic overview ofP PSD PC PMC9454566__F7 Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response CTBP2 SAMD9 IFIT1 TFAP2A EPSTI1 OAS3 BCL2L11 OAS1 IL12RB1 PMC9454566__F8 Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response CLASP2 CGAS SAMD9 USP12 IRF9 IFIT1 EPSTI1 OAS3 OAS1 PMC4528065__F7 Model of CC-122 costimulation of T cells and tumoricidal activity through degradation of Aiolos and Ikaros DDB1 IL2 IRF7 CRBN PMC4672198__F2 MITF function in the nucleus of a melanosome to activate melanin synthesis and secretion and melanocyte growth and survival PAX3 MC1R EDN3 EDNRB KIT SOX10 KITLG CTNNB1 PMC6162501__F2 P53-ARF-MDM2/4 pathway (adapted from the p53 website) BAX MDM4 FAS CDKN1A BTG2 ERCC5 PML MDM2 GADD45A KRAS XPC PMC11881760__F3 Updating on the Dual Role of Salivary Gland Epithelial Cell (SGEC) in Sjögren’s Disease STAT3 CGAS NLRP3 TLR4 AIM2 IRF3 MYD88 PMC6790574__F5 Inflammasome NLRC4 NLRP1 NAIP LTA GSDMD NLRP6 NLRP3 AIM2 FADD PMC6790574__F3 Nucleic acid sensors TBK1 CGAS IRF3 PMC6790574__F1 TLR‐mediated signaling pathway TBK1 IL10 TLR9 IL4 IRF3 IRAK2 TRAF3 IRAK4 MYD88 IFNG TLR3 TLR4 TLR8 TLR7 PMC4985489__F2 Recommendations for Development of Botanical Polyphenols as “Natural Drugs” for Promotion of Resilience Against Stress-Induced Depression and Cognitive Impairment MTOR BDNF HOMER2 PMC3151103__F9 Schematic summary of a signaling pathway underlying IL-1Beta-induced dedifferentiation of primary cultured articular chondrocytes SOX9 IL16 NAMPT SIRT1 PMC6234654__F9 Diagrammatic representation of occurrence of colorectal cancer (a) and various modulatory mechanisms of combinatorial administration of probiotics and celecoxib (b) in CRC with respect to different biomarkers BAX APC GSK3B IL1B PMC1905729__F1 Binding of IL-12 to the IL-12RB1 and B2 chains induces phosphorylation of the kinases Tyk2 and Jak2, which associate with the cytoplasmic tails of the B1 and B2 chains, respectively TYK2 IL12RB1 PMC2876151__F7 Cdk1 modulates the activity of several DNA damage checkpoint proteins CDC2 RFC4 MRC1 RFC2 CDC20 MRE11A DNA2 RFC3 PMC8725472__F8 SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFB/PI3K/AKT/GSK3B pathway CCNE1 CDK2 SCUBE3 TGFBR1 PMC4431663__F1 Physiological regulation and pharmacological inhibition of the STAT3 signalling pathway TF STAT3 SYK SOCS3 PMC8201651__F1 Wnt/Beta-Catenin Signaling and Liver Regeneration: Circuit, Biology, and Opportunities RNF43 LRP5 ZNRF3 LRP6 GPR49 CTNNB1 PMC6321330__F1 Simplified representation showing the interplay between the major signaling cascades activated by tyrosine kinase receptors (RTKs) and TSH-Receptor (TSH-R) DDR1 TSHR MTOR PMC11474142__F3 Major signaling pathways associated with ENPP1 BAX CGAS BCL2 HP PMC8207832__F2 Ubiquitin-dependent protein assembly at DSBs and their roles in DSB repair pathway choice RAD51 KEAP1 BRCA2 USP11 RIF1 MDC1 L3MBTL2 DNA2 BRCA1 RNF8 ATM RFWD3 UHRF1 PALB2 PMC9336077__F2 Molecular biology and therapeutic potential of Nrf2 in leukemia ROR1 RBX1 BACH1 KEAP1 GSK3B SKP1 PMC8511501__F1 Polydatin Ameliorates Osteoporosis via Suppression of the Mitogen-Activated Protein Kinase Signaling Pathway CXCR3 CCR2 PTPN1 AIP PDE5A PTPN11 CXCL10 CCL2 MAPK3 CXCR1 FER MBP RELA AHR MAP2K1 IL8RB RPS6KA3 PMC6770560__F9 Coelonin inhibiting LPS-stimulated activation of NFKB and inducing G1 phase cell-cycle arrest in RAW264.7 cells TLR4 PTEN TRAF6 MYD88 PMC3679471__F6 MSP-RON signaling pathway IFNG TLR4 CCR2 CCL2 PMC12103590__F8 Proposed model of hnRNPL phase separation promoting glycolysis in ovarian cancer HNRNPL PFKFB2 PMC3309874__F1 Insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) is a major candidate pathway in human longevity IGF1 INSR IGF1R INS IRS1 PMC8106283__F1 Preventive Role of Cannabinoids Derivate against Methylphenidate-Induced Oxidative Stress and Inflammation: The Hypothetical Function of Keap1/Nrf2/ARE Signaling and Proposal of a Treatment Strategy for Neurodegeneration BAX BAD KEAP1 IL1B PMC6215878__F6 Diminished inhibin B (INHBB) expression activates the transforming growth factor‐B (TGF‐B) pathway to promote anoikis resistance and migration INHBB SMAD2 SMAD4 PMC4923650__F1 Integration of RDGN with TGFB to regulate EMT SMAD1 DKFZp781O1323 HMGA2 EYA2 SIX1 SMAD2 ZEB2 DACH1 TGFBR1 PMC3915289__F1 The kynurenine metabolic pathway KYNU KMO HAAO IL1B PMC7391499__F5 Lignin biosynthesis pathway and monolignol biosynthesis related gene expression in P CAD DAP PMC9684248__F7 Pyroptosis in inflammation-related respiratory disease STAT3 GSDMD GSDMC DFNA5 IL6 PMC9684248__F8 Pyroptosis in inflammation-related respiratory disease NLRP3 TXNIP AIM2 PMC3510826__F8 Important roles of SFKs in G protein-coupled receptor-induced platelet activation C2 ARHA PMC5337359__F1 Interactions between the canonical Wnt/beta-catenin pathway and PPAR gamma under aerobic glycolysis conditions in colon cancer HEL-S-133P APC LRP5 LRP6 CCND1 CPD CTNNB1 PMC9684248__F1 Pyroptosis in inflammation-related respiratory disease HMGB1 GSDMD NLRP3 TXNIP IL18 CD14 MYD88 PMC9684248__F2 Pyroptosis in inflammation-related respiratory disease GSDMD GSDMC GSDMB DFNA5 GSDMA PMC3202104__F2 EBV infection impacts on cell death and survival pathways in GC B cells CD40 BAX FAS BCR SMAD2 SMAD4 BIK FADD PMC9684248__F5 Pyroptosis in inflammation-related respiratory disease GSDMD NLRP3 TLR4 AIM2 DFNA5 PMC9684248__F6 Pyroptosis in inflammation-related respiratory disease NLRP1 GSDMD NLRP3 TLR4 PMC9684248__F3 Pyroptosis in inflammation-related respiratory disease GSDMD NLRP3 TLR4 GSDMB AIM2 PFAS IL1B PMC9684248__F4 Pyroptosis in inflammation-related respiratory disease GSDMD NLRP3 TXNIP CS PMC7921316__F3 Molecular mechanisms of natural polyphenols in colon cancer COX2 IL1B CTNNB1 FADD PMC10534731__F2 Possible Mechanisms of Dark Tea in Cancer Prevention and Management: A Comprehensive Review HIF1A NOX4 MYD88 PMC8511501__F6 Polydatin Ameliorates Osteoporosis via Suppression of the Mitogen-Activated Protein Kinase Signaling Pathway NFKB2 PTPN1 PTPN11 MAP2K1 GRB2 PMC12110172__F1 Hippo-YAP pathway LATS1 LATS2 PMC12157585__F1 C. elegans fatty acid synthesis pathway and FAT-2 desaturase FAT4 FAT1 GLA FAT2 FAT3 PMC8570281__F1 Genetic Polymorphisms in High-Dose Methotrexate Toxicity and Response in Hematological Malignancies: A Systematic Review and Meta-Analysis DHFR GGH TYMS SLC19A1 HEL-S-70p FPGS PMC8343371__F1 Coronavirus disease-2019: A review on the disease exacerbation via cytokine storm and concurrent management TMPRSS2 ADAM17 ACE2 PMC8318774__F12 Huotan Jiedu Tongluo Decoction Inhibits Balloon-Injury-Induced Carotid Artery Intimal Hyperplasia in the Rat through the PERK-eIF2Alpha-ATF4 Pathway and Autophagy Mediation ATG12 ATF4 PMC3969039__F2 Putative model of the mechanism of vascular homeostasis mediated by apelin-APJ signaling KLF2 FGFR1 PAH FGF2 PMC8732267__F1 Signaling pathways regulated by GA12/13 in solid tumors LATS1 CDC42 LPA STAT3 LATS2 GSK3B RHO JAK1 PMC4180627__F1 The endocrinology of vitamin D CASR NR1i1 DBP CYP24A1 PTH FGF23 PMC3103347__F5 Effect of SCGB3A2 on TGFB signaling pathway STAT3 SKIL EGF SMAD1 DKFZp781O1323 SMAD2 RUNX2 TGFBR2 BAMBI FOXH1 IFNG INHBA FST NOG BMP4 JUN GAL LIF TGFBR3 TNF FOS SKI SPP1 RUNX3 ENG CREBBP PMC10750283__F4 Nuclear Receptors in the Pathogenesis and Treatment of Non-alcoholic Fatty Liver Disease FGF8A NR1C1 DGAT2 CYP7A1 FGFR4 LPIN1 PMC2623309__F1 Multiple feedback loops of p53 pathway MAPK14 CCNG1 SIAH1 CDK2 PTEN MDM2 CTNNB1 PMC7422534__F4 MicroRNA-target interaction networks VEGFC SHC1 RASSF1 IL3 GNG12 CACNA1I NTF3 F2R FGF9 HEL-S-1 HEL2 FGF23 TAOK2 CACNG2 CRKL PPP2R5B DUSP4 FOS FGF2 ITGB1 CASP3 TAOK3 FGFR3 PPP2R2D GRB2 YWHAZ PMC2874322__F4 An Update on the Genetics of Atopic Dermatitis: Scratching the Surface in 2009 CCL3 TLR9 EPO TAP1 NLRC4 RB1 NLRP12 NLRP3 BOLA1 IL13RA1 IRF2 NOD2 APP BMF TAP2 MB CCL17 PMC2874322__F5 An Update on the Genetics of Atopic Dermatitis: Scratching the Surface in 2009 SPRR2E SPRR1B SPRR2F CD14 SPRR3 SPRR2G SPRR2B FLG IVL DEFB1 TSLP SPRR1A IRF2 NOD2 NOD1 SPRR2A CLDN1 PMC8615888__F1 STING Signaling and Skin Cancers NLRX1 CGAS SOX2 IRF3 PMC8341640__F2 Critical Role of PARPs in Regulating Innate Immune Responses TBK1 AKT3 AHR IRF3 IRF7 PMC4433321__F8 Hypothetical involvement of glucokinase (GK) and therefore glucokinase activators (GKAs) in the preservation and growth promotion of pancreatic Beta-cells BAD PDX1 PMC8341640__F3 Critical Role of PARPs in Regulating Innate Immune Responses PARP10 HMGB1 PARP12 PARP1 MYD88 PMC10999489__F2 Personalized treatment concepts in extraocular cancer SUFU SMO PMC3725690__F6 Working model for the NOX dependence of TNFA production by the liver following I/R injury RAC1 PMC11212700__F1 From macroautophagy to mitophagy: Unveiling the hidden role of mitophagy in gastrointestinal disorders PHB2 TBK1 ARIH1 PINK1 PGAM5 BNIP3 MUL1 BNIP3L FUNDC1 SRC OPTN PMC11212700__F2 From macroautophagy to mitophagy: Unveiling the hidden role of mitophagy in gastrointestinal disorders GNAS PINK1 NLRP3 ULK1 MFN2 TLR9 GPR176 BNIP3 BNIP3L GGT7 SIRT1 PMC8341640__F1 Critical Role of PARPs in Regulating Innate Immune Responses TBK1 CGAS PARP3 IRF3 PARP2 SSB PARP1 PMC4174596__F1 Hh pathway response in vertebrates PORCN SMO PMC4918286__F1 Hippo pathway signaling in Drosophila and mammals.Note: (A) Signaling diagram PAX3 RASSF6 BIRC5 LATS2 APP AJUBA NF2 TBX5 AREG FRMD1 RUNX2 PMC6110482__F6 Exposure to nicotine-derived nitrosamine ketone and arecoline synergistically facilitates tumor aggressiveness via overexpression of epidermal growth factor receptor and its downstream signaling in head and neck squamous cell carcinoma BAX EGFR PMC7756113__F3 Mechanism of autophagy SQSTM1 MTOR ATG5 PMC6637043__F9 Schematic diagram showing the proposed signalling pathways for inflammatory and autoimmunity‐associated gene expression via Ca2+ and Ca2+‐dependent/‐binding proteins CD40 STAT3 CSA2 CAST LEPR ERBB2 NFATC3 FGF10 TNF MYD88 PMC9599458__F3 Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities IL6 MTOR NOX4 PMC6563119__F1 Canonical and alternative Hippo pathways HEL-S-31 MAP4K3 MAP4K1 IRF3 MAP4K2 RAP2B TEAD4 RAP2C LATS1 MOB1A MOBKL1A RAP2A LATS2 TEAD2 FOXO1 TEAD3 FOXO3A F3 PMC4226164__F1 Damage-associated molecular pattern signaling mechanisms CDC42 NLRP3 C2 IL1B MYD88 PMC3103347__F7 Schematic diagram for the SCGB3A2-induced inhibition of the TGFB signaling pathway IFNG STAT1 SMAD2 UGRP1 PMC5836099__F5 Mitotic arrest and slippage in inflammation and immunity PIDD1 BAX CGAS CDC20 OMP IRF3 PMC6563119__F5 Dual functions of the cancer cell-intrinsic Hippo pathway in immune modulation LATS1 LATS2 CSF1 TEAD2 TEAD3 CXCL5 CXCL1 IRF1 CXCL2 CCL2 TEAD4 PMC3670510__F1 Targetable metabolic actors by natural compounds GCG FAS HK2 HEL-S-162eP PMC5357299__F8 Schematic overview of the proposed iOGN:TLR4 signaling pathway TIRAP TLR4 TRAF6 MYD88 PMC6563119__F4 Roles of the Hippo pathway in effector T cell differentiation IFNG APC FOXP3 PMC10243112__F7 Machine Learning Reveals Lipidome Remodeling Dynamics in a Mouse Model of Ovarian Cancer C6 TG C2 PC PMC2679172__F1 Crosstalk at the initial encounter: Interplay between host defense and ameba survival strategies GAL C2 CP PMC2756331__F1 Trk receptor tyrosine kinases and major signal transduction pathways CDC42 NGF NTS BAD GSK3A FRS2 RHO GRB2 BDNF PMC4123471__F6 Extracellular Matrix and Liver Disease BAX RAE1 BCL2 PMC4229247__F4 Pathways for initiation and maintenance of psoriasis TLR9 TLR7 TNF PMC4760771__F7 HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells SMO HEL-S-44 PMC8268646__F1 From Messengers to Receptors in Psoriasis: The Role of IL-17RA in Disease and Treatment IL17RC IL25 IL17RA IL17RB TRAF6 TRAF2 PMC9280173__F9 Antiproliferative and apoptotic potential of Glycyrrhizin against HPV16+ Caski cervical cancer cells: A plausible association with downreguation of HPV E6 and E7 oncogenes and Notch signaling pathway BAX BAD CCND1 CDK4 PMC2783351__F2 “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia TIRAP TLR4 TAB3 CD14 IRAK1 TRAF6 IRAK4 MYD88 PMC5372728__F2 Effect of chronic alcohol intake on mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in white adipose tissue from mice EEF2K TSC2 EIF4B TSC1 EIF4E PMC5372728__F1 Lipolytic and lipogenic pathways in white adipose tissue LPL CD36 FASN HEL-S-5 PMC8999811__F1 Jasmonate Signaling Pathway Modulates Plant Defense, Growth, and Their Trade-Offs LOX MED25 MYC PMC8999811__F2 Jasmonate Signaling Pathway Modulates Plant Defense, Growth, and Their Trade-Offs MED25 MYC PMC6750278__F1 Diagram illustrating damage processes and pathways thought to contribute to HC loss due to acoustic overexposure CDC42 JUN ARHA SRC KRAS PMC4566117__F4 Surfactant metabolism SFTPB SLC34A2 CEBPA NKX2-1 PC SFTPC FOXA2 ABCA3 PMC8999811__F4 Jasmonate Signaling Pathway Modulates Plant Defense, Growth, and Their Trade-Offs BIN2 TDP1 LOX CPD PMC5987207__F1A Systems and synthetic biology approaches in understanding biological oscillators MALL APC MAL WEE1 PMC8025964__F6 Summary of SEPT6-regulated Hippo/YAP signaling pathway in HCC LATS1 MMP2 CCND1 PMC6750865__F1 Possible integrated mechanism of cell injury and its relationship with microcephaly ZIKV-induced and cell death RIPK3 BAX ZBP1 NLRP3 IL33 AIM2 IRF1 RIPK1 MTOR PMC6077295__F2 Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis BRAF IGFBP7 KRAS MGMT PMC3954160__F1 Insulin signaling pathway BAD CALML6 SLC2A4 PYGB SOCS4 FASN GSK3B MTOR ACACA INS ARAF HRAS CRK TSC2 PRKCI INSR CBLC GYS1 LIPE GCK GRB2 PKLR PMC6581573__F2 Stylized diagram showing the synthesis, degradation, release and uptake of monoamines, synaptic effectors and targets of methylphenidate TH DBH DRD3 SLC6A2 HTR1B DRD1 DRD2 SLC6A3 DRD4 ADRA2A SLC18A2 DRD5 5HT1A TPH2 PMC7008497__F3 Signals 1 and 2 for nod‐like receptor protein 3 (NLRP3) activation may be delivered by cGAS or TLR9 CGAS TLR9 IL1B PMC3047110__F6 Proposed model for ERG functions in prostaglandin signaling pathway COX1 COX2 C2 HPGD ERG PMC316535__F6 Genetic models for ptp-2 signaling during (A) oogenesis and (B) vulval development EGF EGFR GRB2 PMC4638384__F2 Regulation of the Hippo pathway in Drosophila WBP2 ZYX SCRIB HEL70 PMC4638384__F3 Regulation of the Hippo pathway in mammals LATS1 HEL-S-31 CDC2 WBP2 LATS2 SIAH1 SIAH2 AMOT SCRIB RHO NF2 PMC8576247__F4 Clinical values and potential pathways of miR-183-5p in gastric cancer: a study based on integrational bioinformatics analysis PRICKLE2 COMP NGFR NTRK2 MTOR RELN WNT2B CTNND2 XB COL4A5 CACNA2D3 MAPK10 GHR PMC8247090__F4 Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathway TH PTCH2 BCL2 GLA KIN PMC6639958__F8 Proposed model of MEK as a key regulatory pathway of the IFN response against RV and RSV in airway epithelial cells HEL164 STAT3 TLR3 STAT2 IFNAR2 EGFR IFNAR1 IRF3 PMC4638384__F1 Inhibition of YAP/TAZ transcriptional coactivators by LATS1/2 LATS1 TEAD2 TEAD3 VGLL4 TEAD4 PMC4638384__F4 Therapeutic targeting of the Hippo pathway LATS1 LATS2 TEAD2 TEAD3 RHO TEAD4 PMC10418941__F2 Molecular crosslinks produced by the interaction of the HSCs and LSCs CDH2 KLF4 CYR61 PMC3773501__F1 NOD2, an Intracellular Innate Immune Sensor Involved in Host Defense and Crohn's Disease MAVS ATG16L1 NOD2 IRF3 IRF4 PMC5495050__F3 BRD4 pathway in acute myeloid leukemia (AML) cells BRD4 FLI1 CDK6 CHD8 ERG MYC TEF NSD3 PMC10418941__F3 LSCs’ microenvironment in relation to epigenetic modification PTPRC PTEN VEGFA IL6 TNF RUNX2 MYC CD44 CTCF TLR4 LAMB3 TLR7 CD68 PMC10418941__F4 LSCs mechanism that employs fat as fuel ALOX5 SOX2 PMC7933526__F10 Mechanism underlying renal-protective effect of QYDP TF SMAD2 SMAD4 CTNNB1 PMC8504268__F1 Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88 TIRAP CD14 TNF LBP IL1B MYD88 PMC8475840__F1 Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection HK2 EGLN2 PMC5442467__F8 Summary of the impact of keratins on the Notch1 signalling pathway HEY2 NOTCH1 PMC3855091__F6 Foxa2 deletion leading to premature aging and age-onset obesity TSC1 STAT5B DDIT4 SESN3 IRF3 FOXA2 MTOR TRIB3 PMC8834130__F1 Oral Immune-Related Adverse Events Caused by Immune Checkpoint Inhibitors: Salivary Gland Dysfunction and Mucosal Diseases CD40 ICOS CD80 BCR GC PC PMC4464753__F7 Long-Term Mild, rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus IGF1 APOE IGF1R BDNF TNF IGF2 IRS1 IL1B PMC2837572__F2 An overview of the signalling pathways mediated by TNFA in metastasis TNF CSN2 CTNNB1 PMC9562907__F1 Complement in nonalcoholic fatty liver disease C2 C1S C1R PMC2837572__F1 Downstream signalling pathways of TNFA TRADD TRAF2 FADD PMC6601209__F1 Graphic depiction of the gene engineering strategy and glycoproteomics workflow GALNT3 GALNT1 GALNT9 GALNT5 GALNT8 GALNT4 C1GALT1 GALNT12 GALNT16 GALNT10 GALNT7 PMC4601184__F1 IGFR1, a possible target in tumor progression and metastasis TF EGF IGF1 EGFR MMP2 MMP9 PMC6073226__F4 Mechanism of modulation on sphingolipids by chrysin (A), curcumin (B) and genistein (C) SMS SPHK2 SPHK1 PMC7469703__F5 CSHMM predicts the precise timing of Wnt modulation as a determinant of cell fate NKD1 AXIN2 WIF1 PMC3749695__F8 Cumulative scheme adapted from the data published in (, –, , , , , ) showing components of pathways implicated in regulating the life span in Drosophila and their interactions RHEB TSC2 TSC1 KEAP1 PRX PTEN PMC10750282__F2 CGAS-STING Signalling in Metabolic Diseases: from Signalling Networks to Targeted Intervention TBK1 CGAS IRF3 MMP9 PAX6 CCL2 VSIG4 LATS1 ALDH2 PDE3B GSDMD TLR3 TLR4 ABCC8 VCAM1 TRAF2 PMC8802753__F3 Polyphenols and omega-3 PUFAs: Beneficial Outcomes to Obesity and Its Related Metabolic Diseases IL10 IL13 IL6 PMC6852943__F2 Inhibitory effect of miRNAs on their target molecules in the UPS pathway UBE3A HEL-S-71 UBE2B USP2 CBX4 UBE2A UBE2I PMC7786163__F2 Links among COVID-19, cytokine storms, and HF STAT1 STAT2 CCL3 CCL2 IL1B PMC10750282__F3 CGAS-STING Signalling in Metabolic Diseases: from Signalling Networks to Targeted Intervention TBK1 CGAS ULK1 AIM2 IRF3 SQSTM1 MTOR TRAF3 TRAF6 IRS1 MYD88 NLRP3 IFNAR2 TLR4 IFNAR1 PMC6505634__F3 MEF-2 isoforms' (A-D) roles in development and tumorigenesis RHEB MYOT MTOR FOS PMC7796017__F2 PI3K/AKT/mTOR signaling pathway and breast cancer RHEB EGFR FGFR1 IGF1R PMC4593004__F2 Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan SOX17 RAB4A PLCB4 ROBO1 MLSN2 MAST2 PSD3 HIVEP3 SLIT3 EXOC2 KCNQ5 CMTM8 NR5A2 PMC10882078__F7 TNF signaling pathway in atherosclerosis-related and non-related to CKD TRADD ITCH SP3 TRAF3 TNF CASP10 TRAF2 FADD PMC7564975__F2 Different ratios of STAT3A/STAT3B and their functions in therapy sensitivity STAT3 EGFR SRC PMC4618389__F1 Vulture-specific genetic change in immune system NOD2 CD14 IRF7 NOD1 LBP PMC5088527__F7 Linking the circadian clock with the NAD+ salvage pathway NAMPT SIRT1 PMC9005797__F1 Holistic Approach to Immune Checkpoint Inhibitor-Related Adverse Events CD80 APC PMC3594751__F7 Schematic view of the roles of S-PCNA and Srs2 in the rescue of stalled replication forks RAD18 POLM RAD51 PCNA POLN PMC7544739__F2 Interactive roles of SOCS1 and SOCS3 in TLR signaling SOCS1 TBK1 TLR3 TLR4 MAL IRF3 IRF7 SOCS3 TRAF3 TRAF6 SKI MYD88 PMC5088527__F2 Biosynthesis pathways of acetyl-CoA and NAD cofactors, and their involvement in chromatin-related processes VIT NAMPT SIRT1 PMC4511319__F4 Signaling network of endothelin axis (ET) and micro ribonucleic acid (miRNA)-200, the ET axis can be influenced by miRNA-200c on different pathways (red arrows: induction of pathway; black arrows: blockade of pathway) SMAD2 ZEB2 PMC6731444__F8 A scheme for DMF induced SOCS3/JAK1/STAT3 signaling pathway in HCC cells STAT3 SOCS3 VEGFA JAK1 ATG5 PMC7145703__F4 Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics IFNE SYK STAT1 IRF9 CTSK BLNK FHL2 NFATC1 GRB2 CYLD GAB2 PMC3721332__F2 Interactions between nTreg (A) or IL-2 activated inducible Treg (Tr1) with effector T cells (Teff) mediated by the adenosine and PGE2 pathways COX2 FOXP3 PMC4516433__F5 Cerebral nitric oxide represses choroid plexus NFKB-dependent gateway activity for leukocyte trafficking IFNG CSA2 CXCL10 CCL2 TRAF2 PMC10215584__F5 PPI network analysis according to STRING database and KEGG pathway enriched in DEPs in the groups of (A) MRC vs SLC26A3 PLIN4 MANBA HMGCL HEL-S-273 MRO GALNS LAMA4 COL3A1 NR1A2 PRKCB PMC7145703__F5 Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics EGF LTA LTBR TRADD TIRAP LAT TNFRSF1A NGF PLCG1 PLCG2 COX2 BCR TLR4 ATM IL1B CD14 BLNK PARP1 LTB CNTF EN1 LYN VCAM1 LBP LCK PMC5938338__F7 Schematic of Ca2+signaling pathway activated by alkaline stimuli to dentin surface and PLC-coupled receptor activation in odontoblasts TRPA1 PMC7915495__F3 Protective effects of small-molecule natural products on OS in CKD SIRT3 CGA GSK3B SFN ERG SIRT1 PMC4911704__F1 MTOR in maintenance of glomerular epithelial cells TSC2 TSC1 SGK1 ULK1 TBC1D7 PMC9504399__F3 Feedback Regulation of Signaling Pathways for Precise Pre-Placodal Ectoderm Formation in Vertebrate Embryos BAMBI SMAD1 SMURF1 DKFZp781O1323 SMAD6 SMAD4 PMC9504399__F4 Feedback Regulation of Signaling Pathways for Precise Pre-Placodal Ectoderm Formation in Vertebrate Embryos RIPPLY3 ANOS1 MEIS3 FER TBX1 IRX1 GRB2 FLRT3 PMC5949255__F3 Deciphering p53 Signaling in Tumor Suppression DNMT3B TET2 THBS1 CALD1 MSH2 TET1 ULK1 UVRAG ATG2B SLC7A11 RHO XPC ATG10 DDB2 SCO2 MDM2 ULK2 PMC7391449__F1 Cellular Oxygen Sensors TFRC HK2 EPO BNIP3 HIF1A PMC5797050__F3 Identifying characteristic miRNAs-genes and risk pathways of multiple sclerosis based on bioinformatics analysis DAP OMA1 PMC5797050__F4 Identifying characteristic miRNAs-genes and risk pathways of multiple sclerosis based on bioinformatics analysis MAX ECSIT MPL JUN FAS CD14 NPAT FLNA PMC10866657__F2 BMP9-10/ENG/ALK1/SMAD4 signaling pathway maintains vascular quiescence by repressing angiogenic pathways BMP10 SMAD1 DKFZp781O1323 SGK1 SMAD2 SMAD4 PTEN VEGFA TGFBR1 VEGFB ENG PIGF CDK6 CDK4 PMC5858934__F4 Model for RHO/ROCK-dependent regulation of trophectoderm-lineage specification AMOT RHO NF2 PMC4303468__F18 Generation and metabolism of H2S PMC4060729__F2 Flowchart showing the induction of ER stress and its physiological outcomes during coronavirus infection EIF2A XBP1 PMC6667284__F1 Intracellular interactions and fates of microbes opsonized with C3 in the extracellular milieu MAVS ATG16L1 HEL-S-62p PMC8711024__F7 Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL-mediated NFKB and JNK and their downstream signalling pathways DCSTAMP NFATC1 TRAF6 PMC9247874__F3 Long Non-coding RNAs With In Vitro and In Vivo Efficacy in Preclinical Models of Esophageal Squamous Cell Carcinoma Which Act by a Non-microRNA Sponging Mechanism TG CDKN2C SPRY4 E2F4 ATM GADD45A SUV39H1 HCTP4 PMC3352318__F7 Association of mitochondrial peptidyl Cys with functional networks according to reduction and oxidation of Cys residues MTCH2 EGF TGFB1 ETFB UQCR10 IKBKE MGST1 TUFM CYC1 HEL-S-51e UQCRQ NDUFAB1 ACADM SLC25A4 GLUD1 SLC27A1 ETFA UQCRB PNO1 UQCRHL TNIP3 UQCRC2 UQCRH PC NDUFB3 MDH2 ECHS1 KIF11 GOT2 LTC4S VEGFA TNF UQCRC1 SDHA SDHB UQCRFS1 NFKBIA ERBB2 GRB2 NDUFS1 SDHC PMC7827005__F1 Activation of signaling pathways (selected) in MM cells in the BM microenvironment STAT3 BAD IGF1 WNT3A DKK1 PDC RELB MTOR MYC PMC7827005__F2 Cell adhesion-induced activation of signaling pathways IGF1 BCL2 EZH2 IL6 VCAM1 PMC6134795__F1 Composite pathway using the KEGG pathway analysis, a composite pathway was generated based on the canonical mapping of the phosphorylated proteins independently associated with increased % collagen (red) in the liver FAS LIMK2 LIMK1 TRAF2 PMC5636987__F6 Proposed working model: POPX2 regulates the TAK1-IKK-NFKB pathway during DNA-damage-induced apoptosis MAP3K7IP1 TAB3 ATM TRAF6 PMC6544937__F5 miR-15/107 family targeted genes in cell cycle KEGG pathway calculated by miRPath v3.0 web-server DBF4 RAD21 CDK7 PCNA PRKDC CREBBP CDK2 REL PMC3352318__F6 Association of nuclear peptidyl Cys with functional networks according to reduction and oxidation of Cys residues KIR2DL4 THOC2 RAN CLIC1 PCNA SNUPN THRAP3 NUMA1 U2AF2 KHDRBS2 NXT1 ELP5 SRC HNRNPK CASC3 TNPO2 SRP19 RBM8 HNRNPAB DBF4 HNRNPL ARRB2 HNRPA3 WBP11 PCBP1 RNMT TNF MAGOH DEK ANP32B SF1 HNRNPA2B1 PRKDC IPO5 XPOT RBM42 PMC12102218__F8 Diagram illustrating the mechanism through which ISM5939 potentiates antitumor immune responses HEL-S-92n CGAS ENPP1 PMC3352318__F4 Association of cytoplasmic peptidyl Cys with functional networks according to reduction and oxidation of Cys residues CCT4 FLNA EPCAM PABPC4 YWHAQ RPS3 MYO1C AIMP2 CLTC CAP1 TUBA1A FLNB ANXA4 HEL-S-133P FASN EIF2S2 EEF1B2 ATP1A1 LDHB ANXA1 PPP2R1A MIF EIF2S3 TUBB STK39 HEL-S-34 CAND1 CCT7 ACTN4 HEL-S-68p RPL10A PLEC HEL-S-69p HEL-S-87p PS1TP5BP1 YWHAZ PMC7736605__F1 Autophagy influence on tumor-associated antigen presentation 1 TH CD80 PMC6329627__F1 PG biosynthesis, receptors and signalling pathways COX1 RHO PMC2567408__F8 NCAM upregulation leads to a functional switch FYN FRS2 SHE PMC3302445__F7 How BRG1 and CHD4 antagonistically influence Wnt signaling during yolk sac vascular development CHD4 CTNNB1 PMC6329627__F2 Lymphocyte‐mediated chronic inflammatory responses IL25 TSLP IL33 PMC5850516__F1 Transforming growth factor B activated kinase 1: a potential therapeutic target for rheumatic diseases MAP3K7IP1 TLR4 TRAF5 IRAK1 TLR5 IL6 TRAF6 TRAF2 IRAK4 MYD88 PMC6329627__F3 Molecular mechanisms for PGE2‐cytokine crosstalk in facilitation of adaptive Th1 and Th17 cell responses CD40 STAT3 CRTC2 IL2 IL23R PMC4926172__F1 Schematic overview of viruses that subvert the PI3K/Akt/mTOR signaling pathway RHEB TSC2 TSC1 ITGB1 PTEN MTOR PMC4926172__F2 Downstream targets of mTORC1 RHEB CDC2 MTOR ELF3 PMC8328766__F3 Astrocytes: a double-edged sword in neurodegenerative diseases TF STAT3 SOCS3 RHO MTOR DDC PMC8910224__F4 Micro-Current Stimulation Suppresses Inflammatory Responses in Peptidoglycan-Treated Raw 264.7 Macrophages and Propionibacterium acnes-Induced Skin Inflammation via TLR2/NFKB Signaling Pathway TRAF6 MYD88 PMC8278373__F2 Therapeutic approaches targeting the GFB in clinical or late preclinical development CDC42 TRPC5 ARHA TRPC6 RAC1 PMC11757730__F7 Anti-inflammatory effects of chamuangone in lipopolysaccharide-induced murine (Mus musculus) RAW264 TLR4 MYD88 PMC3855406__F2 Signaling pathways of NFKB activation CD40 LTBR TRADD PSD TRAF6 FADD PMC8678573__F3 Lipid Droplets, the Central Hub Integrating Cell Metabolism and the Immune System SNAP23 SYK FYN PC PMC7658535__F7 Signaling pathways induced by prolonged exposure to H FOXO4 ATG12 IKBKB GADD45B BNIP3 NOD1 BIRC2 BCL6 PMC8306561__F3 Autophagy Inhibition in BRAF-Driven Cancers RHEB TSC2 ULK1 TFEB BRAF ATF4 MDM2 EIF2A PMC5003635__F3 Oridonin regulates multi-signaling pathways to display corresponding multifunctional effects BAX KEAP1 APAF1 PMC8306561__F2 Autophagy Inhibition in BRAF-Driven Cancers ATG101 ATG10 ATG3 ATG14 ATG5 PMC7710892__F3 The CoQ10 biosynthesis pathway COQ8B COQ8A COQ7 PDSS1 COQ3 COQ2 COQ9 COQ6 COQ5 PMC3980962__F1 Origins and implications of pluripotent stem cell variability and heterogeneity STAT3 FGF7A SOX6 SMAD1 BMP4 LIF SOX2 RBL2 OLIG2 OTX1 TBX3 ZIC2 PMC11064142__F8 A) Interaction of mir15a/16-5p cluster and mir-7641 with targeted genes involved in intrinsic and extrinsic signalling pathways of apoptosis BAX JUN PCNA MCL1 E2F7 PTEN VEGFA BCL2L11 MYC KRAS CCNE1 CDKN1B MEI1 BCL2 TLN1 CCND1 PMC3744446__F1 Past Visits Present: TCF/LEFs Partner with ATFs for Beta-Catenin–Independent Activity TCF4 ATF2 LEF1 CTNNB1 PMC7275976__F1 SARS-CoV2 replication cycle and potential targets of CQ/HCQ TLR7 ACE2 PMC7838196__F10 AGE-RAGE signaling pathway in diabetic complications TF SELE DAO PMC8475840__F4 Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection TSC2 TSC1 CASTOR1 SIRT1 PMC2858431__F1 Developing Antiepileptogenic Drugs for Acquired Epilepsy: Targeting the Mammalian Target of Rapamycin (mTOR) Pathway RHEB TSC2 TSC1 PTEN MTOR EIF4E PMC9022965__F2 Four enzymatic pathways that drive PL remodelling PODN HEL-S-5 PC PMC5896114__F4 Location of si:ch211-167b20.8, socs9, eif4e1c and CALML6 in the insulin signaling pathway RHEB ELF4 TSC2 BAD FAS CBL INSR FOXO1 GRB2 MTOR INS PMC3755284__F1 Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization C6 NPS NHS HEL-S-162eP IL13RA2 PMC3159114__F1 Modulation of cellular reactive oxygen species (ROS) PRX GPX1 NOX4 PMC8573605__F1 Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data RELA PDC RELB PMC4762627__F4 NFE2L2-Regulated Antioxidant Response in Activated Microglia HEL-S-107 PPIB GCLM GSK3B SQSTM1 ME1 HEL-S-94n VCP USP14 TXN FTH1 CCT7 EPHX1 ME2 GCLC CLPP HEL-75 PMC12203236__F2 Targeting Molecular Pathways in Breast Cancer Using Plant-Derived Bioactive Compounds: A Comprehensive Review STAT3 EGFR PTEN MTOR SKP2 PMC9506445__F1 Association of Homologous Recombination–DNA Damage Response Gene Mutations with Immune Biomarkers in Gastroesophageal Cancers BARD1 FANCD2 ATR RAD51 BRCA1 BRCA2 CHEK2 ATM PALB2 PMC7802183__F7 As a biomarker for gastric cancer, circPTPN22 regulates the progression of gastric cancer through the EMT pathway IFNA7 NDUFB8 APPL1 FBL GNG12 CSTB SH2D1A PDX1 PARP11 PRKCE APOH NPFF CLCN2 PAX5 SYT2 CNR1 DCTN3 TPTE ZNF549 LPP SPANXN5 NR5A2 OCSTAMP PCDHGA7 PLEKHG7 SLC6A17 GRP ELAC1 HIRIP3 IFNA17 SPDYE3 NGL1 DEFA4 NMNAT2 B3GALT2 FAM83F RADIL DBI ARL15 RGS4 AK4 TIMD4 PMC3164150__F1 The insulin receptor (IR) with its two subtypes IR-A and IR-B, the insulin growth factor 1 receptor (IGF-IR) and the hybrid receptors (IGF-1R/IR-A and IGF-1R/IR-B) IGF1 IGF1R IGF2 PMC7603197__F1 Aberrant FGF/FGFR signaling in breast cancer CBL FRS2 APP GRB2 PMC3164150__F2 Insulin-like growth factor 1 receptor (IGF-1R) signaling pathway TSC2 BAD TSC1 IGF1 PTEN GRB2 MTOR IGF2 IRS1 PMC4940047__F2 Regulation of hepcidin production STAT3 TFR2 TWSG1 GDF15 EPO HAMP HFE IL6R HFE2 PMC3585130__F1 The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network DPH1 DPH2 DPH3 DPH5 EEF2 PMC3585130__F2 Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network DPH1 DPH2 DPH6 DPH7 LAP3 DPH5 NDE1 PMC4860420__F2 Reelin signaling mechanisms in brain development and function CRK DAB1 FYN VLDLR MTOR SRC PMC4330253__F3 Illustration of molecular pathway for significantly associated single nucleotide polymorphism (SNP) loci in the metabolic syndrome genome-wide association study (GWAS) ZW10 CENPH BCL10 CARD10 AURKB INCENP APOE ZWINT CENPE CCL20 MGMT PMC9923939__F1 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action BAX EGFR CD19 PTEN CCND1 PMC2277216__F1 Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history TLR9 IRF3 IRF7 TLR7 IRF8 IRAK4 MYD88 PMC9923939__F2 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action TRADD CD14 TRAF6 TNF TRAF2 MYD88 PMC6929103__F3 KEGG based pathway analysis of 86 genes reveals their significant role in different pathways, as shown in the figure, such as immune response pathways PLN CAV2 FAS PPIF CD36 ATP2B4 PTPRC PECAM1 MEF2C SPP1 CD34 HLA-DRA EDNRA EDNRB LAMA4 KDR PMC9923939__F3 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action FAS RAF1 TRADD TNF TRAF2 PMC9923939__F4 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action BAMBI MMP7 APC CCND1 CTNNB1 PMC9923939__F5 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action STAT3 BAX EGF BAD TGFA EGFR GSK3B PTEN MTOR SRC PMC9923939__F6 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action BAX FAS CDK6 CDK2 MDM2 CDK4 PMC4878077__F4 Shows the schematic presentation of the IFNA/B and IFNG receptors linked to the Jaks for the TO-VS-IFN/SAV3 and TO-VS-SAV3 IFNG STAT1 IFNGR2 IFNGR1 STAT2 IFNAR2 IFNAR1 JAK1 TYK2 PMC8377872__F5 Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus OGT RAB11FIP2 STXBP3 PMC9923939__F7 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 NODAL PMC9923939__F8 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action TSC1 GSK3B TBC1D7 PTEN DEPTOR PMC9923939__F9 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action KCTD11 PTCH1 DHH SHH IHH SMO MYC GLI3 PMC4878077__F5 Shows Jak/stat pathway analysis for the TO-VS-IFN/SAV3 and TO-VS-SAV3 using the KEGG pathway software analysis CBL PIM1 IL3 EPO IL2 IL6 PMC7386875__F1 Proposed mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, and coronavirus disease 2019 (COVID-19)-associated thrombosis TF TMPRSS2 FURIN ACE2 PMC4528959__F6 Quantitative phosphoproteomic analysis of IL-33 mediated signaling CDC42 ABI2 HEL114 FGD1 PXN F2 APC RHO INS PMC7386875__F4 Treatments for targeting coronavirus disease 2019 (COVID-19)-associated thrombosis TMPRSS2 HMGB1 ACE2 PMC3161051__F7 Rad6B/Beta-catenin regulation in breast cancer cells with autocrine Wnt activity APC LRP5 LRP6 CTNNB1 PMC4578258__F1 The schematic model for the regulation of the transcription of the srf operon network involved in two extracellular signaling peptide-mediated quorum sensing in B COMP PMC6424728__F1 Promoting immune evasion by Hippo pathway EGF EGFR CXCL5 IL8RB PMC3934928__F2 Cell biological view of Toll-like receptor function: regulation through compartmentalization TIRAP TLR4 TLR9 CD14 TLR5 TLR7 TRAF3 MYD88 PMC3617288__F8 Model for the new PLD2-Fes-Jak3 pathway PLD2 JAK3 PC FES PMC8628936__F2 Organizer and Its Signaling in Embryonic Development SMAD2 APC GSK3B LRP5 SMAD4 NODAL SRC CTNNB1 PMC3119055__F4 Gene Expression Profiling of Preovulatory Follicle in the Buffalo Cow: Effects of Increased IGF-I Concentration on Periovulatory Events IGF2R FRZB PLAT FOXO1 DIPLA1 EGFR DBI RGS16 FHL2 PMC6953127__F1 The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases ATG3 ATG12 WIPI2 ULK2 PMC3119055__F5 Gene Expression Profiling of Preovulatory Follicle in the Buffalo Cow: Effects of Increased IGF-I Concentration on Periovulatory Events IGF2R PLAT FOXO1 DIPLA1 DBI DPP4 PLG HEL110 MTOR DCN PMC3296187__F1 Schematic representation of the RKIP signaling pathway and its effects on metastatic progression to the bone BACH1 HMGA2 CXCR4 PMC9705593__F1 Crucial role of T cells in NAFLD-related disease: A review and prospect CXCR3 STAT3 CXCL10 CCL20 PMC6885781__F4 Toxic function evaluation in cancer EVs JUP ITIH2 HEL-S-62p KPRP ANXA2 HRNR SERPINA1 HMCN1 HEL-S-78p HEL-S-2a APOB FGA HP HBB PMC3678031__F2 The amygdala and medial prefrontal cortex: partners in the fear circuit CLC PC CS PMC6287101__F7 Overview of complement cascade activation and targets of inhibitors MASP1 CD59 FH C7 MASP2 HEL-S-62p C2 IL13 CD46 CD55 C4A IL1B PMC2924916__F3 P-values for testing association of the genes within the MAPK signaling pathway with RA in NARAC studies MAX ECSIT EGF JUN FAS FLNB BRAF MYC TRAF6 KRAS NGF MOS RRAS NLK BDNF TRAF2 PMC4377868__F1 Biological roles of sulphate and pathways of sulphate homeostasis SOST CDO1 PAPSS2 CTH SUOX PMC7328459__F1 Dysregulation of Cell Death in Human Chronic Inflammation TRADD OTULIN TNF RIPK3 SHARPIN MAP3K7IP1 C2 RELA TRAF5 RIPK1 TRAF2 CYLD FADD PMC3398916__F7 The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network CDC42 TIAM1 APC GSK3B PMC2924916__F2 P-values for testing association of the genes within the MAPK signaling pathway with RA in WTCCC studies MAX ECSIT EGF TAOK2 JUND CD14 TNF FLNA CRK NGF NTF3 MOS PRKCA NLK GRB2 BDNF TRAF2 CDC25B PMC3008507__F5 A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets WASF3 PLK1 CDC42EP3 MAPK14 RB1 SNAI1 F10 RBPMS MARCKSL1 NPM1 TBP LAT2 SAA1 CDH24 LRP6 HOXB4 NRG2 ONECUT1 ACTR3 UGDH MYCBP2 EIF3B NPPC FOXD1 COX1 GSTT2 PROCR LGI1 SLC26A2 ATP10A CHEK2 YWHAG RASA4 EWSR1 LTC4S LZTS1 RRM2 POLR3F CCDC91 RBL2 KLHDC3 EIF5 CDX1 GKAP1 ASGR1 CHST6 KITLG MDFI GTF3C1 PHB2 GTF3C2 GTF3C5 MPZL2 KCNJ10 PLEKHA6 POLR3C BTN2A1 KLF5 NASP KIF20A DDR2 TRAF6 SERPINB8 GNAZ PNKP TMEM126A ATP8B2 IL16 SART3 DHPS BATF ID2 FZD2 JUNB HEL-117 EIF4G1 MGAT3 SNW1 AIF1 HEL-S-76p ITM2C LAT FZD10 TMEM109 DOCK11 CTNNB1 ALDH2 CD300A APOH P2RY2 UMPS AK5 IL27RA RPS6 EIF4B EIF4EBP1 LIF FZD9 F13A1 PTPN11 GJB2 PTPRN2 GJB1 SSB RPL6 SEC31A NR1C1 SAMD9 GJA1 PMC4695001__F7 Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo GAL ARV1 MDM2 PMC8703004__F2 Alterations in Lysosome Homeostasis in Lipid-Related Disorders: Impact on Metabolic Tissues and Immune Cells BCR CD36 APC IMPACT PMC5076483__F4 Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events DNMT3B TDG PMC11889934__F3 Molecular modifications of lactylation in cancer MADD STAT3 SEMA3A GPR37 KAT5 HEL-S-133P PER1 ULK1 YTHDF2 EP300 VCAM1 VEGFA PMC11889934__F4 Anticancer strategies targeting lactylation LATS1 SIRT3 SPOP HEL-S-133P HK2 HIF1A CTGF PMC4805479__F2 Involvement of dWAT in Hair Follicle (HF) Synchronization.Synchronous cycling of HFs is connected with long-range paracrine signaling VIT NR1i1 SHH PMC11192909__F0 Mechanism of NGR1 in alleviating colitis APC LRP5 LRP6 GPR49 CTNNB1 PMC8096981__F2 Inflammation-Mediated Angiogenesis in Ischemic Stroke BAD EGFR EPO PTEN PMC8741355__F4 Study of Yin-Chen-Hao-Tang Preventing and Treating Alcoholic Fatty Liver Disease through PPAR Signaling Pathway Based on Network Pharmacology and RNA-Seq Transcriptomics LPL EHHADH UBC CYP7A1 HEL-S-28 ACD PLTP PMC2756763__F1 Aromatase: synthesis of estrogen in postmenopausal women and its inhibition by aromatase inhibitors HSD17B1 STS PMC7378193__F7 Regulatory network of MYO18B mRNA that reflect the survival outcome in hepatocellular carcinoma IFNG MYL5 MYO18B MYO1B IFI27 CEBPB PMC7183444__F3 Hypoxia/re-oxygenation-related KEGG pathway and differentially expressed genes(a) von Willebrand factor (VWF), complement component 1, q subcomponent, A chain (C1QA), and complement and coagulation cascades pathway VWF CCL3L3 MAFK BAD FH CPB2 HEL-S-62p F7 CR2 CS RHO DAO DOCK2 C1QA TFPI F2 CD9 F10 F3 WAS C9 PC CCL4L2 CXCR4 PMC4512830__F6 Examples of IPA software outcome: hsa-let-7 and their target genes in Human Embryonic Stem Cell Pluripotency Pathway JUN SP1 ATF2 FOS CP PMC2074956__F3 Schematic representation of the carbon catabolic pathway, the bifid shunt, and oxalic acid degradation AGA PMC3118436__F2 Metabolic remodeling in cancer cells and regulation by signaling pathways involving oncogenes and tumor suppressor genes FAS GLS HEL-S-133P HK2 TIGAR MYC HEL-S-26 PMC3644824__F2 A schematic diagram of Mycobacterium tuberculosis (Mtb) infection and clearance via the autophagic pathway IFNG ESX1 IRGM RAB8B PMC6477881__F2 The mTOR-signaling pathway in ASD RHEB TSC2 TSC1 NF1 PTEN MTOR EIF4E PMC6207557__F1 Mechanisms by which rLrp inhibits the production of LPS-induced cytokines TLR4 GSK3B SOCS3 TRAF6 MYD88 PMC7306500__F2 Protein-protein interaction network (STRING database) generated by combining all biomarkers of different omic types, reviewed earlier in the report PLCD3 HS3ST2 DBP HEL113 ATP2B1 FGF14 CD72 NFKB2 ADRA1D HEL111 CRH PLAC1 COX17 PSMD1 PER3 TFRC PRDX3 PAPPA2 INHA ADAM12 EPHX2 APOC3 FSTL3 TIMP3 HEL-S-91n TNFRSF14 SMS AMBP GCLM SERPINA1 CDX1 FABP4 BHLHB2 SIAE PROX2 ATF3 INVS SLC2A6 CYP11A1 MYCBP2 DPP7 NPVF LMCD1 CSHL1 HP KRT13 PMC7322056__F6 Role of HX109 in prostate epithelial-macrophage crosstalk and inflammatory response of macrophages STAT3 TLR4 CCL4 PMC7749079__F1 Hippo signaling in embryogenesis and development LATS1 LATS2 AMOT RHO SRC VGLL4 PMC12238593__F5 Deregulated molecular signaling pathways and crosstalk in glioblastoma CSA2 EGF HGF EGFR APC GSK3B LRP5 LRP6 PTEN MTOR TNF DEPTOR CTNNB1 RHEB TSC2 TSC1 NF1 JAK1 LEF1 NOTCH1 IL1B PMC12238593__F6 Key immune signaling pathways regulating tumor-associated immunosuppression ZAP70 IDO1 SMAD2 SMAD4 MTOR SRC PMC12238593__F4 Genetic alterations driving glioblastoma pathogenesis MYB ATR CDC20 EGFR BRAF SOX2 MN1 PTEN AREG MTOR KRAS RB1 CDKN2A CDK2 ATM MDM2 CDK4 PMC12238593__F9 Transcriptional and epigenetic regulation and functional dynamics in CD8+ T cell exhaustion CXCR3 ID2 FOXO1 FOXO3A F3 TOX ID3 RUNX3 PMC4014333__F1 Biosynthetic pathway of prodigiosin PIGC PIGF PIGH PIGN PIGA PIGB PIGL HBM PIGM PMC4765774__F4 N-Terminal-Based Targeted, Inducible Protein Degradation in Escherichia coli CLPP CLPS CLPX PMC5323377__F10 Schematic representation of the difference between Ctenopharyngodon idella melanoma differentiation-associated gene 5 (CiMDA5) and C IRF3 IRF7 PMC3975838__F1 Janus kinase 2 (JAK2)/signal transducer and activation of transcription (STAT) and hedgehog (Hh) signaling pathways in normal development (A) and mechanisms of Hh signaling in cancer (B) PIM1 SUFU MCL1 BCL2 SMO CCND1 GLI3 PMC7724349__F8 Selaginellin B induces autophagy and apoptosis in ASPC-1 and PANC-1 cells through activating the JAK2/STAT3 signal pathway STAT3 BCL2 PMC3224393__F1 Reaction scheme for EGFR signal transduction pathway in H1299 cells EGF CBL EGFR GRB2 PMC9635867__F1 RNA m6A methylation regulators in endometrial cancer (Review) IGF2BP1 SOX2 IGF1R YTHDF1 MTOR IRS1 COL1A1 PEG10 PHLPP2 F10 WTAP YTHDF2 METTL14 METTL3 HOXB13 CCND1 SOX4 PMC6291723__F4 Main lipid-lowering effects of berberine through the APMK pathway TG HNRNPD LDLR PMC3385990__F3 Gp130 mediated IL-6 family of cytokines signaling pathway SOCS1 STAT3 SOCS3 IL6 GRB2 PMC7418153__F1 An overview of Wnt signaling pathway KLHL12 RNF43 APC GSK3B LRP5 ZNRF3 LRP6 GPR49 CTNNB1 PMC7013402__F2 Greatwall- Endosulphin Alpha (ENSA) pathway in the control of G1 and G0 HEL-S-66p CDC26 RICTOR TPK1 WEE1 PPA2 NAT1 PMC7418153__F2 An overview of non-canonical Wnt signaling pathway CDC42 PTK7 RYK ARHA RAC1 DAAM1 PMC2913986__F6 Gene Chip analysis reveal SOX11-induced regulation of Rb-E2F and TGFB signaling pathways MAP3K7IP1 PMC9604510__F2 Cell Component and Function of Tumor Microenvironment in Thyroid Cancer SRC PMC8835893__F5 Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance SUFU DHH DYRK1B SHH IHH SMO PMC7758837__F1 Emerging therapies in Parkinson disease — repurposed drugs and new approaches PINK1 GDNF LRRK2 PARK2 SNCA LAG3 PMC8835893__F2 Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance NUMB SMO ARHA MTOR SRC RAC1 PMC9246413__F2 Temozolomide – Just a Radiosensitizer? ATR MPG ATM MGMT PMC5911630__F7 The role of ACSS3 as a prognosis biosignature of GCa SC5D LDLR GCA CS ACSS3 MVK PMC8835893__F1 Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance SUFU DHH SHH IHH SMO PMC5366285__F9 Cartoon illustrating a novel signaling pathway for the coordinated regulation of Rho and Rac signaling in epithelial invasion GIT2 CRK RHO DOCK5 PMC8352204__F3A Machine Learning Identifies Clinical and Genetic Factors Associated With Anthracycline Cardiotoxicity in Pediatric Cancer Survivors MYB MED10 GJB7 SEC62 PMS1 TGM1 LITAF TGM3 MCU CELF4 CYBA UACA DYNAP ZNF71 ZNF827 DKFZp686O2396 PMC4027041__F1 Hepatic S-adenosylmethionine (SAMe) metabolism HEL-S-182mP HEL-S-61p PMC4546523__F2 Biosynthesis of heparin/heparan sulfate and chondroitin sulfates GAL GLA CS UST PMC5228377__F6 The signaling pathways involved in wogonin-induced autophagy ULK1 MTOR CYLD PMC9477170__F3 Inflammation resolution concept NLRP3 COX1 COX2 IL13 PMC11419411__F2 Molecular mechanisms and pathways associated with PCa bone metastasis cells (By Figdraw) TBX2 STAT3 FZD8 CDK5 IFITM3 SMAD4 CCL5 KRAS TNF CTNNB1 PMC2727884__F2 Mechanism of action of sorafenib TGFA EGFR VHL PMC11787113__F2 Phenotypic and functional characteristics of tumor-infiltrating B cells determine their overall impact on tumor progression or suppression FOXP3 PMC9635867__F2 RNA m6A methylation regulators in endometrial cancer (Review) RHEB TSC2 TSC1 PHLPP2 METTL14 YTHDF2 PTEN METTL3 PMC3864081__F1 DAMP signaling through different PRRs TIRAP IL16 NOD2 IRF3 IRF7 NOD1 MYD88 PMC11640923__F4 Iron handling in the brain HEPH HAMP PMC8388390__F4 Effect of GP19 Peptide Hyperimmune Antiserum on Activated Macrophage during Ehrlichia canis Infection in Canine Macrophage-like Cells IL19 IL10 IF2B1 IFNA13 CSF1 IL12A IL13 OTULIN FLT3LG IL4 IL10RA TNF IF2G IL-21 IFNG IFNGR2 IL24 IF2D PSMB10 A2M IL11 IL12B IL23A PMC11640923__F5 Pathomechanisms of FTD that might involve iron imbalance FUS EWSR1 UBQLN2 FTMT TAF15 PMC3281649__F9 Proposed model for the inhibition of Notch1 signaling pathway by Fe65 ITCH HES1 NOTCH1 HES5 PMC11640923__F2 Intestinal iron absorption (left) and iron handling in a generic cell (right) TF TFRC HEPH MFN2 ABCB7 HAMP FTMT PMC7789003__F1 Synthetic view of key functional losses (−) and gains (+) during the evolution of Myzozoa COX1 COX3 FES PMC9648404__F8 Sexual dimorphism of early transcriptional reprogramming in degenerating peripheral nerves DUSP5 OGT EGF TGFB1 HGF RAF1 EGFR IL3 F7 CSF3 MAPK3 POR IFNG EREG F2 CREB1 IL1B CYP1A2 LIF TNF CYP1A1 FGF2 HRAS APEX1 EDN1 NFKBIA GPER ERBB2 PTH PMC11640923__F3 Iron homeostasis by cellular iron levels (left) and oxidative stress (right) FTH1 TFRC FTL KEAP1 SNCA APP SQSTM1 PMC8582450__F10 Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer PAK1 COPA SRC RAC1 PMC7828590__F1 ERA activity through genomic and nongenomic actions TF SP1 SRC PMC4021685__F1 Schematic simplified demonstration of the main mechanisms supposed to be involved in fatty acid and TNF family interaction at different levels of colon epithelial cell organisation IFNG LOX TRADD TNF TRAF2 FADD PMC6132443__F2 Role of NaPiII family of sodium–phosphate cotransporters in the intestines and in the kidney FGFR1 PTH FGF23 PMC9260022__F4 ILP-2: A New Bane and Therapeutic Target for Human Cancers BCL2L1 MTOR PMC6126464__F2 The IL-6 receptor signaling pathway that is regulated by TRAF2 and TRAF5 STAT3 TRAF5 TRAF2 PMC7919195__F6 Signaling pathway network of potential AA targets HSP90AB1 CA4 CA7 CA13 ADRA1A KIT HTR2A VEGFA DRD3 FGF2 HTR2B HRAS HTR6 PSENEN DRD2 ADRA2A ADRA2B PSEN2 ADRA2C CA14 PMC8172602__F9 Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet PGP FASN SIRT1 PMC11033433__F2 Research progress on radiation resistance of cervical cancer RAD51D MTDH SIRT4 NEK2 BCL2 WNT1 EP300 HNF1A HMGB3 PMC3444627__F1 Cytokine Combination Therapy Prediction for Bone Remodeling in Tissue Engineering Based on the Intracellular Signaling Pathway SMAD1 DKFZp781O1323 SMAD2 BMP2 MSC PTH RUNX2 CTNNB1 PMC4413642__F6 Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/Beta-catenin pathway SLIT2 ROBO1 SRC CCND1 CTNNB1 PMC6286919__F1 Schematic representation illustrating the signaling molecules that regulate the PD-1/PD-L1 transcription STAT3 CD80 APC PTEN JAK1 PMC3886813__F1 NFKB and STAT3 signaling in glioma: targets for future therapies RHD RELB PMC11033433__F6 Research progress on radiation resistance of cervical cancer MMP7 HDAC1 MMP2 PMC3886813__F2 NFKB and STAT3 signaling in glioma: targets for future therapies STAT3 OSM PMC11033433__F7 Non-coding RNAs involved in the regulation of radiation tolerance in cervical cancer (A) the relationship between lncRNAs and radiotherapy resistance in cervical cancer STYX RAD51 RRM2 CXCL1 CRKL PTEN MTOR YY1 CDK6 CDKN1A ELAVL1 HOXB7 YTHDF2 METTL3 CCND1 PMC11033433__F4 Research progress on radiation resistance of cervical cancer ZNF582 KLK5 ATM CCNB1 PMC516236__F1 Simplified representation of molecular mechanism involved in insulin signaling pathway that regulates glucose transporter (GLUT4) translocation to cell membrane PI3 PTEN IRS1 PMC7563597__F2 Molecular mechanism of extrinsic and intrinsic pathway involved in apoptosis BAX BAD TRADD MEI1 BMF TNF FADD PMC4938032__F3 Signals shared after brain injury and in the NSC niche EGF GFAP TGFA EGFR SMAD2 SHH SMAD4 OLIG2 MTOR FGF2 PMC10153444__F2 Contribution of the dihydropyrimidinase-like proteins family in synaptic physiology and in neurodevelopmental disorders CDK5 SEMA3A FYN PMC3210456__F7 Cyclin D1 action and degradation USP2 GSK3B CCND1 PMC8232086__F1 Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review MTDH MYC CTNNB1 PMC8232086__F2 Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review ELF4 SUFU SMO PTEN EXT1 MDM2 MTOR PMC11930081__F8 Proposed signaling pathway activated by oxidative stress in NHEKs CKAP4 TXN FOXM1 TXNIP DKK1 EGFR PMC7788945__F1 IL-22R downstream signal transduction pathways STAT3 STAT1 JAK1 TYK2 PMC7200337__F6 Immunology of COVID-19: Current State of the Science TLR9 TLR7 CCL2 ACE2 IL6R PMC10538627__F2 Research progress on the role of the Wnt signaling pathway in pituitary adenoma APC GSK3B AXIN1 LRP5 LRP6 WNT4 AXIN2 WIF1 CTNNB1 PMC8723792__F3 Translational science of cancers with SWI/SNF complex aberrations ATR CDK6 ARID1B FGFR1 EZH2 MDM2 CDK4 SMARCA4 PMC3856862__F10 Therapeutic Strategies to Increase Human Beta-Cell Growth and Proliferation by Regulating mTOR and GSK-3/Beta-Catenin Pathways RHEB TSC1 IGF1 MTOR IRS1 CTNNB1 EIF4E PMC8584977__F5 Wnt Signaling in Inner Blood–Retinal Barrier Maintenance FZD4 LRP5 LRP6 CTNNB1 PMC4473799__F3 Targeting signaling factors for degradation, an emerging mechanism for TRAF functions TBK1 MAVS TLR4 MAL RELA RELB IRF3 TRAF3 TRAF6 TRAF2 MYD88 PMC8932066__F4 Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments CD81 CD9 CD82 CD63 PMC10538627__F1 Research progress on the role of the Wnt signaling pathway in pituitary adenoma CDC42 APC AXIN1 LRP5 CYC1 LRP6 ATF2 ARHA MYC RAC1 AXIN2 CTNNB1 PMC9331252__F6 Mulberry Leaf and Neochlorogenic Acid Alleviates Glucolipotoxicity-Induced Oxidative Stress and Inhibits Proliferation/Migration via Downregulating Ras and FAK Signaling Pathway in Vascular Smooth Muscle Cell PCNA RAC1 PMC8299464__F2 Stress Hormones: Emerging Targets in Gynecological Cancers NGF ADAM17 BDNF PMC4320218__F1 PI3K/Akt/mTOR signaling pathway RHEB TSC1 IGF1 ULK1 PMC7576747__F3 Intervention to reduce ROS for the prevention of CIN: evidence from in vitro, in vivo and clinical studies NQO1 RHO MTOR SIRT1 PMC7576747__F2 CIN via complex pathways of ROS from in vitro and in vivo studies STAT1 SP1 RHO SIRT1 PMC10571651__F1 Normal physiologic MET receptors form dimers upon HGF signaling, and Cbl binding leads to ubiquitination CBL HGF GRB2 SRC PMC8310235__F3 Human Papillomaviruses Target the DNA Damage Repair and Innate Immune Response Pathways to Allow for Persistent Infection TBK1 STAT1 CGAS MAVS STAT2 IRF9 IFI16 IRF3 EIF2A TYK2 PMC2992472__F4 The regulatory network of apoptosis in BCL11B and its related genes BAX BCL2L1 CREBBP TNFSF10 ATL1 SPP1 FADD PMC8344275__F1 Deregulation of HLA-I in cancer and its central importance for immunotherapy IFNGR2 IFNGR1 IFNAR2 EGFR IFNAR1 IRF1 B2M TGFBR1 PMC8071039__F2 Signaling pathway and cell survival BAD JAG2 BCL2 IMPACT PMC10309513__F2 Triggering receptor expressed on myeloid cells 2–apolipoprotein E signaling pathway in diseases LPL SALL1 BAX CSF1 CST7 AXL CLEC7A APOE MAFB ITGAX SPP1 TREM2 FABP5 CD9 CD33 GPNMB CD68 PMC8071039__F4 Signaling pathway and cell migration RHO IMPACT CTNNB1 PMC4647707__F3 Differentially expressed genes in the toll-like receptor signalling pathway (ko04620) CD40 IL19 TIRAP CTSK CD14 IRF3 IRF7 TRAF3 TRAF6 IRAK4 RAC1 MYD88 TLR3 TLR4 LBP FADD PMC6912555__F1 Canonical and noncanonical Wnt signaling pathways RNF43 PORCN TNKS APC GSK3B ZNRF3 RYK RHO LEF1 RAC1 CTNNB1 PMC2734294__F3 Several molecular features in the cell body of an oxidatively stressed neuron KEAP1 NQO1 PMC4647707__F4 Differentially expressed genes in the cytokine-cytokine receptor interaction pathway (ko04060) PRLR FLT3 LTA LTBR OSM IL3 EPO CCL2 IL-21 CCL23 INHBB INHBA INHBE FLT4 CCL21 EPOR IF2D CCR7 KDR GHR BMPR2 TNF CNTFR TSLP CCL25 IL9R CCL4 IL23R EDAR FAS LEP CCR3 IL2RA MPL IFNK CCR6 IL2 GHB2 IL9 KIT IL4 IL20RA IF2G SF1 IL24 PRL BMP2 CCR4 IL6ST TNLG7C PMC3340256__F1 tBID structure and mechanism of action MTCH2 TNF PMC5707070__F8 Alpha-Tocopherol prevents esophageal squamous cell carcinoma by modulating PPARGamma-Akt signaling pathway at the early stage of carcinogenesis BAX BAD PTEN MDM2 PMC5381403__F1 Exome sequencing identifies frequent mutation of MLL2 in non–small cell lung carcinoma from Chinese patients PRKD3 EZH1 GAS7 ATR CTR9 MYO16 SMYD1 KDM5B EGFR KRAS ENY2 FOXG1 HERC2 INHBA INSR PPP1R9B ATM EP300 RFC3 TTF1 SMARCA4 LCK PMC6901958__F1 HSV-1 mediated evasion of the DNA-sensing pathway in innate immunity TBK1 CGAS HNRNPA2B1 STAT2 LAT IFNAR2 IRF9 IFIT3 CH25H IFI16 IRF3 TYK2 PMC9405826__F7 ALCAM: A Novel Surface Marker on EpCAMlow Circulating Tumor Cells EGF NFKB1 MMP2 BCL2 CTNNB1 PMC7472745__F5 G2/M cell cycle arrest and mechanisms by which it is affected by Vpr ATR DCAF1 ATM PLK1 EME1 PMC4171549__F2 Computational gene interaction predictions: network of E12 telencephalon-specific miRNA involved in the Neurotransmitters and other nervous system signalling pathways CDC42 DNAJB1 GPR37 SP1 EGFR ARPC3 NRP1 BACE1 LAMC1 ADCY9 TUBB2A IKBKB CALM1 BDNF HNRNPK KCNJ2 CAP1 PMC11670864__F1 Generation of B10 cells via in vitro stimulation of TLR pathways BLK CSA2 TLR4 TLR9 BLNK IRF3 TRAF3 MYD88 PMC8503602__F3 Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms GSK3B TFEB LRP5 BNIP3 LRP6 CTNNB1 PMC11670864__F2 BCR and CD19 signaling pathways work together to promote production of IL-10 CD19 MTOR SRC PMC7472745__F1 Replication cycle of HIV: graphical depiction of the major events of the HIV replication cycle CCR5 CXCR4 PMC10778571__F3 Pathways regulated by DKK-3: insights into DKK-3 functions CKAP4 DKK3 APC ROR2 LRP5 LRP6 PMC3843585__F2 The PI3K signaling pathway RHEB BAD PTEN MDM2 SRC PMC2757120__F1 Canonical PI3K signaling pathway RHEB TSC2 JUN TSC1 GSK3B PTEN MYC IRS1 PMC3189826__F1 p130Cas and p140Cap signalling involved in migration and invasion CRK CSK ERBB2 SRC PMC2882232__F2 Simplified representation of oncogenic signaling cascades in pancreatic cancer HGF CCK EGFR APC GSKIP SMAD4 LRP6 PTEN IGF1R MTOR SRC CTNNB1 PMC9454979__F6 Novel Insights into miR-944 in Cancer STAT3 STAT1 EGF MACC1 SOCS4 EGFR GC GATA6 MDM2 CISH SRC CTNNB1 PMC6036858__F1 Yeast cell cycle pathway from the KEGG database SIK1 MCC CDC20 APC MAL ORC1L NET1 CLN3 ORC3 ORC2 CIB4 C2 CDR2 PMC6657977__F7 Circular RNA profile in liver tissue of EpCAM knockout mice TES LPL CAST JUN TNFAIP3 MPHOSPH9 JKAMP IFIT1 ASB7 FACL4 CNNM3 IFIT2 PTEN SGPP2 NAIP IFNGR2 SMPD4 RARA RICTOR HNF1A FAT3 PMC3189826__F7 Signaling pathways leading to 3D invasion of ErbB2 transformed MCF10 cells over-expressing p130Cas ERBB2 MTOR RAC1 PMC11719987__F6 Role of Notch signaling in modulating ferroptosis and its contribution to cataract formation FTH1 GPX4 SLC7A11 PMC7066404__F9 Potential mechanisms of hKLK1's protective effects on DMED BAX TGFB1 SMAD2 PMC6036858__F2 Gene network of the yeast data related to the cell cycle pathway via the JMCCM DBF4 MCM7 CDC20 MCM3 MCM5 MCM6 APC2 CLN3 ORC3 PMC3823407__F8 Proposed model of the effect of crocetin on cardiac hypertrophy, inflammation and fibrosis SMAD2 GATA4 PMC8566568__F5 RNASeq analysis of drought-stressed guayule reveals the role of gene transcription for modulating rubber, resin, and carbohydrate synthesis ACAT1 IPP ACAT2 PMC8826583__F2 Long Noncoding RNA GAS5: A New Factor Involved in Bone Diseases GDF5 FOXC2 BMP2 HDAC5 RUNX2 CTNNB1 PMC5502539__F4 Complement factors are targets for pharmacologic inhibition in retinal disease HEL-S-62p CFD PMC5705340__F2 KEGG Ras signaling pathway with targetable nodes highlighted in red BAD LAT NOM1 DAO PMC4203564__F1 KIAA1524/CIP2A promotes cancer growth by coordinating the activities of MTORC1 and MYC CIP2A EIF4EBP1 RPS6KB1 MYC PMC9315392__F3 B-Cell in the Pathogenesis of Systemic Sclerosis CD40 ICOS CD80 IL10 BCR PDC CD22 CD19 IL6 IL1B PMC6063820__F2 Maintenance of a quiescent primordial follicle is regulated by Hippo and Akt signaling LATS1 LATS2 FOXO3A PTEN RHO PMC7807182__F6 LPS affecting glucose metabolism in cervical cancer cells through FRA1: LPS inhibits p53 by inhibiting the expression of FRA1, which regulates the levels of glycolysis and aerobic oxidation by affecting downstream GLUT1, G6PD and SCO2 COX2 HEL-S-133P SCO2 MDM2 PMC6063820__F3 Activation of a primordial follicle is regulated by Hippo and Akt signaling LATS1 LATS2 FOXO3A PTEN RHO PMC10136584__F1 WNT signaling pathways CDC42 APC LRP5 LRP6 ARHA NLK DAAM1 PMC1190355__F8 A model of IRAK1c regulation of inflammation TRAF6 IRAK4 MYD88 PMC6591252__F8 The proposed model for the scaffolding role of the IQ3 motif in IQGAP1 towards the PI3K-Akt pathway EGF EGFR IQGAP1 PMC3174148__F4 Predictive Power Estimation Algorithm (PPEA) - A New Algorithm to Reduce Overfitting for Genomic Biomarker Discovery HLA-DRA PRMT2 CTSH TRPV2 HLA-DOA RFXAP FABP4 CNP PMC3972890__F6 CXCR4 negatively regulates keratinocyte proliferation in IL-23-mediated psoriasiform dermatitis STAT3 CXCL12 IF2B1 SOCS3 CXCR4 PMC10411462__F8 Function and mechanism of PARP inhibitor in thyroid cancers RNF146 PARP1 PMC8700581__F3 Senescence Alterations in Pulmonary Hypertension BMPR2 IL6 NOX4 PMC8194268__F1 Mesenchymal Stem Cell Protects Injured Renal Tubular Epithelial Cells by Regulating mTOR-Mediated Th17/Treg Axis RHEB STAT3 MSC MTOR PMC9194868__F2 Fueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity PNP NRK NAPRT SARM1 NMNAT1 HEL-S-162eP NMNAT2 NMNAT3 PMC8700067__F4 Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease ATG12 ULK1 TFEB MTOR PMC8700067__F2 Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease HEL-S-72p ATG12 ULK1 MTOR PMC8700067__F3 Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease HEL-S-72p PINK1 TIRAP TLR4 PARK2 SQSTM1 OPTN TBC1D15 MYD88 PMC9170180__F1 Three Proliferation Pathways (Wnt, Notch, and Hippo) in Intestine and Immune System and Their Role in Inflammatory Bowel Diseases (IBDs) LATS1 APC ADAM10 PMC8922216__F2 Metabolic and Signaling Roles of Ketone Bodies in Health and Disease ACLY ACSS2 CIC AACS PMC6129971__F1 Pathways of one-carbon metabolism VIT PMC7920303__F3 Metabolism of small, neutral amino acids including serine (Ser), glycine (Gly), and alanine (Ala) VIT SLC25A38 PHGDH GPT2 SLC38A1 PSAT1 SLC1A4 MPC1 SFXN1 MPC2 PSPH PMC11993586__F1 Lipid synthesis pathways and associated proteins in this review CDC2 CDS1 GPT2 ORM1 PC IDI1 GHB3 PSD2 ORM2 PMC5131952__F7 Silver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE Receptor ORAI1 STIM1 PMC8836921__F1 IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment OSM OSMR LIF IL11 IL6 PMC7478175__F7 The complosome in T cell homeostasis CTSL IL7R CD46 NOTCH1 PMC4767381__F2 The canonical pathway of miRNA biogenesis and the mechanisms of miRNA controlled posttranscriptional gene regulation TH AGO2 DROSHA PMC7422669__F3 Engulfment of apoptotic tumor cells induces LAP to inhibit type I IFN response and polarize tumor associated macrophages toward the immunosuppressive M2 phenotype IFNG IL1B PMC7422669__F1 Clearance processes for apoptotic cell by phagocytes rely on “find me” and “eat me” signals that signal their internalization (A) “Find me” signal: apoptotic cells release signals that attract phagocytes to the site of programmed cell death CXCR3 TGFB1 CX3CL1 MERTK PMC6563926__F1 Physiological pathways of LRRK2 activity RAB10 LRRK2 TLR4 RAB7L1 PMC6033032__F2 Schematic/pathway representation of the FOXO‐p53 interplay in cellular senescence FOXO4 FOXO1 FOXO3A F3 ATM PMC6838865__F1 Canonical and non-canonical mammalian autophagy processes ATG101 ATG12 UVRAG ATG14 MTOR PMC5026797__F1 mTORC1 re-wires GI cell metabolism upon glycolysis inhibition to promote growth and proliferation CAD PMC8483912__F3 Stingless Bee Propolis: New Insights for Anticancer Drugs CDC2 EGF BAD HGF IGF1 CDKN1A CDKN1B CDK2 PTEN MTOR CCND1 PMC11701242__F6 Molecular mechanisms of phase separation in TGFB, NFKB, and JAK-STAT pathway STAT3 SMAD2 SFPQ SMAD4 TNF CTNNB1 PMC11701242__F7 Phase separation-mediated MAPK/ERK activation of T cell signaling pathways ZAP70 PLCG1 CSH2 LAT APC GRB2 LCK PMC9710158__F1 Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells CSF2 CSF1 CCR2 BMP2 SIRPA CD163 CCL2 KITLG CD47 CD68 PMC11701242__F4 Pathogenesis and therapeutic resistance mediated by the phase separation of the Hippo pathway LATS1 BRD4 TBK1 LATS2 DDR1 MAVS NONO IRF3 EP300 MAMLD1 NF2 MED1 PMC11701242__F5 Molecular mechanisms of phase separation in cGAS-STING-mediated innate immune responses TBK1 CGAS IRF3 IRF7 TREX1 SIRT1 PMC11701242__F3 Mechanism and activation of the Hippo pathway through phase separation LATS1 LATS2 SLMAP AMOT PMC3073741__F1 Complement and Viral Pathogenesis C6 FH HEL-S-62p C9 CR2 C4A CR1 PMC5356782__F2 Therapeutic potential of targeting the PI3K pathway in pediatric brain tumors BAD PTEN MDM2 MTOR CCND1 PMC6632497__F5 Modulating PI3K-Akt signaling pathway of SCD SYK BAD BCR RAE1 RBL2 PTEN MDM2 MTOR PMC11012486__F1 Identification of PTPN12 Phosphatase as a Novel Negative Regulator of Hippo Pathway Effectors YAP/TAZ in Breast Cancer LATS1 WWP1 FAT4 LPA LATS2 AXL ITCH AMOT RHO PTPN21 PMC5356782__F1 Therapeutic potential of targeting the PI3K pathway in pediatric brain tumors BAD PTEN MDM2 MTOR CCND1 PMC4449903__F1 Visualized thrombosis network TF MAPK4 VAV3 VAV2 HRG DAP VAV1 PMC9380231__F6 Effect of Rhizoma Drynariae on differential gene expression in ovariectomized rats with osteoporosis based on transcriptome sequencing NPAS2 ACTA2 EDN1 MMP3 PMC8766410__F3 Adenosinergic Signaling as a Key Modulator of the Glioma Microenvironment and Reactive Astrocytes ADORA2A ADORA2B ADA PMC3980079__F1 Heart Failure and Loss of Metabolic Control LPL TG CD36 HEL-S-5 PC CPT2 HEL-S-30 PMC11701242__F9 Phase separation in Notch signaling for oncogenic Myc activation and developmental fate control BRD4 CCDC85C NUMB MED1 RBPJ PMC6278416__F11 ERK/MAPK signaling pathway in liver metastasis of colorectal cancer FLNB MAP2K6 PRKX GRB2 PMC6283264__F7 The TLR pathway and let-7e target mRNAs CD40 NOS2 CD80 TBK1 CASP8 TIRAP TLR9 CD14 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 NR1C1 TLR1 MAP3K7IP1 COX2 TLR4 IL1B FADD PMC8947257__F8 Proposed model of RTK bypass pathway activation in Tpl2 -/- keratinocytes STAT3 INSR EGFR GRB2 MTOR PMC8533192__F7 Irradiation Mediates IFNA and CXCL9 Expression in Non-Small Cell Lung Cancer to Stimulate CD8+ T Cells Activity and Migration toward Tumors CXCL9 IFNG CXCR3 CGAS PRF1 IL2 CXCL10 PMC4449815__F8 Inactivation of a GAs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis SUFU SHH SMO NF2 YAP1 PMC6520835__F1 Canonical SMO-dependent HH/GLI signaling GPR161 BOC SUFU SMO GLI3 PMC6520835__F2 Genetic and molecular mechanisms conferring resistance to SMO inhibitors GPR161 BOC SUFU SMO MTOR PMC5218554__F9 Wnt Signaling Prevents the AB Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons WNT3A APC GSK3B LRP6 PMC7244035__F7 Schematic figure represented the functions of KIF23 in the Wnt/Beta-catenin signaling pathway in GC APC PRC1 GSK3B AMER1 CCND1 CTNNB1 KIF23 PMC9355403__F8 Of ATP5MG to Treat Metabolic Syndrome-Associated Cardiovascular Diseases NDUFB8 COX5A MDH2 ATP5MG HEL-S-44 PMC6520835__F3 Therapeutic targeting of oncogenic HH/GLI signaling in cancer cells resistant to SMOi STAT3 BRD4 EGF JUN GPR161 SUFU APC DYRK1B SMO IL6 MTOR HES1 PMC6245347__F4 The miRNA-target genes involved in cancer signaling pathways PTH2 FAS PTEN MYC HEL2 PMC6697716__F6 Putative signalling pathway of Ctyl1 CYTL1 SOX9 CCR2 PMC5228544__F1 Roles of TBX2 and TBX3 in tumorigenesis and tumor progression CDH2 TBX2 EGR1 AKT3 PIWIL1 PML PTEN TBX3 MDM2 PSCA CTNNB1 PMC3505266__F3 Heterogeneity in the differentiation and function of memory B cells IL-21 BCR PMC3959597__F7 Cross talk between metformin, androgens, and IGF system and molecular mechanisms of metformin inhibitory effects MTOR SRC PMC9632889__F10 Potential mechanism of the effects of leonurine attenuating cardiac fibrosis in heart failure GSDMD SMAD2 COL3A1 PMC7350219__F1 Cytosolic DNA sensing and pathway activation TBK1 CGAS IRF3 TRAF6 PMC4080180__F12 Current understanding of LPA/LPA5R stimulation of NHE3 activity and mobility based on current studies and the previous reports from the laboratory of Yun and colleagues (, ) LPA EGFR RHO NHERF2 PMC4636730__F2 Proposed schematic of intracellular immune response to murine norovirus (MNV) infection STAT1 IRF3 IRF7 ISG15 PMC3359223__F1 Glycolysis metabolic pathway PGAM1 ENO2 HEL-S-68p HEL-S-49 HEL-S-162eP DLD PMC2136409__F8A Genetic and epigenetic mechanisms of gene regulation during lens development CDH2 FOXE3 SIX3 BMP4 SOX2 CDK2 BMP7 PAX6 HES1 EYA1 PMC7282943__F1 Transforming growth factor-beta in immune suppression and chronic inflammation of squamous cell carcinomas TRAF4 SMAD2 SMAD4 RHO TRAF6 TGFBR1 PMC7161743__F2 Leishmania heme auxotrophy CPOX FECH UROD UROS PMC9120235__F4 OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization MADD CD40 TRADD TIRAP CD40LG TNF MYD88 MAP3K7IP1 MAP2K4 MAP2K6 TNFSF11 SRC MAP2K3 FADD PMC9120235__F5 OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization GMPPB PMM1 PMC11343602__F8 Schematic diagram illustrating the mechanism and intervention strategies of the IL-27/Blimp-1 axis in regulating Tim-3 expression on Tregs STAT3 STAT1 TIGIT PMC6469996__F6 Pathways regulated by NNMT and proposed working model of mechanisms of action of NNMT inhibition as it relates to muSC activation and metabolic state in aged muscle tissue NNMT NRK AOX1 NAMPT SIRT1 PMC3996895__F1 Biogenesis of canonical and mirtron miRNAs in animal cells RAN DGCR8 DROSHA PMC6669816__F8 Mechanism by which eucalyptol protects APAP induced liver injury CYP2E1 KEAP1 APP PMC3996895__F2 Canonical NFKB signaling network regulated by miRNAs CYLD MYD88 PMC5504484__F4 Signaling pathways assigned to the Ingenuity Pathway Analysis (IPA) category “molecular mechanisms of cancer” that have been linked to ovarian cancer and targeted by epigallocatechin‐3‐gallate (EGCG) MAX BAX JUN BAD APC BRAF MYC DAO IRS1 RBL1 CRK SUFU SMO GRB2 LEF1 CCND1 PMC3383335__F1 SnoN Signaling in Proliferating Cells and Postmitotic Neurons PIAS1 PMC7600388__F1 Summary of hepatic lipid metabolism pathways altered in NAFLD and driving dyslipidemia ANGPTL8 PCSK9 TG NR1C1 PNPLA3 ANGPTL3 FGF21 FASN LDLR PMC4400057__F3 NEMix: Single-cell Nested Effects Models for Probabilistic Pathway Stimulation EGFR CACNA2D3 PMC3797786__F3 Identification of Cisplatin-Regulated Metabolic Pathways in Pluripotent Stem Cells APRT ENTPD5 NDUFB2 DHFR PCCA SMOX ACACA MCEE PRKCB CANT1 PARS2 FARS2 PCMT1 APOBEC1 NME4 AK1 UCK2 FARSB UMPS CYP27A1 GAA NME3 SMS RRM2 ENTPD6 FECH HEL-S-304 GPD2 GNE TK1 PFKP ADK ACADL ASNS PRODH PYCR2 TPMT ADA PMC9465159__F1 Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy ATR CGAS MAVS IL4 IRAK1 IRF3 IRAK2 IRF7 IL6 TRAF3 TNF SSB IRAK4 PARP1 MYD88 WEE1 ATM IL1B PMC5955808__F1 Colorectal cancer prevention: immune modulation taking the stage APC BRAF CTLA4 KRAS CTNNB1 PMC2924553__F1 BMP signal transduction SMAD1 DKFZp781O1323 SMAD4 NLK SKI CTNNB1 PMC5674651__F2 Homocysteine metabolic pathway HEL-S-61p MTR PMC8129370__F3 Value of miRNAs in the prognosis of obese patients receiving bariatric surgery ADAM17 FOXO3A PMC7760708__F6 Top two signaling pathways regulated by miR-215-5p in CRC CD44 VWF JUN VASP FYN CD36 DMP1 HEL-S-28 PTEN ARHA CHAD CD47 PMC8951629__F2 Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a Coin TBK1 MAVS TRIM25 IRF3 IRF7 TRAF3 TRAF6 MYD88 PMC4361049__F1 A stepwise demonstration of the hepatitis C virus internal ribosome entry site (HCV IRES) translation initiation pathway ELF2 EIF2D IL1A EIF5B EIF2A ELF3 PMC8085490__F5 Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma MLYCD ACLY STK11 GLS NDUFA9 OTC MYC UCP2 ACSS2 SIRT3 SUCLG1 C11orf98 SBNO1 NDFIP2 CDH4 MDH2 TINCR HEL-S-44 BAX GOT2 SIRT4 SIRT5 HIST1H2BE PCK2 PDHA1 PGAM2 FOXO3A ACADL PFKL CP PMC9454445__F2 Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer NRK NAPRT HEL-S-90n NADK NAMPT PMC3170128__F5 Innate and adaptive immune responses to cell death HMGB1 NLRP3 TXNIP PMC3164983__F1 mTOR inhibitors in renal cell carcinoma RHEB TSC2 RICTOR TSC1 MTOR EIF4E PMC4381889__F4 KRAS-reprogrammed glutamine metabolism in pancreatic cancer.Notes: In KRAS-mutant pancreatic cancer, mitochondrial glutamine flux is reprogrammed to predominantly flux through GOT2, instead of the canonical GLUD1 pathway GLUD1 GOT2 ME2 HEL-S-32 ME1 KRAS PMC11897528__F2 Lipid metabolism in GBM cells ELOVL2 EGFR LDLR PMC4818529__F1 The comparison of different biosynthetic pathways for propane production FAS HBD PMC5344790__F1 Metabolic interactions with cancer epigenetics NNMT HEL-S-182mP MTAP PEMT HEL-S-61p PMC6477784__F1 The inflammasome as a gear or cogwheel that couples purinergic signaling with the complement cascade (ComC) in the process of HSPC mobilization HMGB1 IL1B PMC4381889__F1 NADPH production from the oxidative PPP and one-carbon serine catabolism pathway.Notes: Oxidative PPP uses glucose to generate NADPH via G6PD and 6PGD NADK NAMPT TIGAR PMC7838852__F1 Diversity and versatility of p38 kinase signalling in health and disease ZAP70 MAP3K7IP1 MAP2K6 PMC7838852__F3 Diversity and versatility of p38 kinase signalling in health and disease HNRNPA0 ULK1 FGF21 ZC3H10 UCP1 EZH2 SOX10 TNF RUNX2 DROSHA PAX7 IFNG LAMP2 GFAP RUNX1 IGF1 CDKN1A RBM7 IFNAR1 RIPK1 GADD45A DLX5 CCND1 IL1B PMC6477784__F3 The interplay between purinergic signaling and ComC activation during mobilization of HSPCs HMGB1 PLCB2 S100A9 PMC11897528__F5 Double-edged sword of metabolic reprogramming in GBM, showing the balance between resistance mechanisms and therapeutic vulnerability GPX4 HK2 FASN RELB IMPDH2 LCN2 ABCA1 PMC8306223__F2 Updating of Biological Functions of Methyltransferase SETDB1 and Its Relevance in Lung Cancer and Mesothelioma FOSB SMAD2 ANXA2 APOE SETDB1 HEL-S-44 PMC11936992__F3 AMPK regulates the mechanism of action of FNIP1 RHEB TSC2 TFEB FLCN FNIP1 OPTN PMC11936992__F5 Interaction of FNIP1 with autophagy MYOG TCF12 MYH7B CCL8 FNIP1 PMC11936992__F6 Action of FNIP1 in causing cancer RHEB TSC2 TSC1 STAT2 EGFR TFEB FNIP2 FLCN RHO FNIP1 PMC6271242__F1 The PI3K signaling pathway and sides of action PI3K/Akt/mTOR pathway inhibitors MLST8 RICTOR BCL10 BCR CARD11 PTEN PMC5523860__F7 HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development HNRNPAB SNAI1 SOX9 MSX1 HAS2 HAND2 TWIST1 PMC8617296__F9 Quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus JUN EGFR VEGFA TNF MAPK3 PMC12077450__F2 CysLTs in lung injury EPX IL25 HMGB1 MBP IL33 TNF PMC4338749__F1 Drugs that inhibit folding or disposal of misfolded proteins HDAC6 PMC8581318__F10 SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/B‐catenin pathway APC CCND1 CTNNB1 PMC6480217__F7 Hypothetical scheme of CA action in mammalian cells NGF KEAP1 ATF4 ASNS EIF2A AKR1B10 TRIB3 PMC4197569__F2 Proposed model for autophagy that implicates PLD PLD2 MTOR CTNNB1 PMC7442051__F1 Mechanism of autophagy ATG12 ULK1 BNIP1 MTOR ATG5 PMC6742496__F7 Proposed Model - LPCAT1 Links Genetic Alterations of Key Components of the Growth Factor Receptor Machinery with Plasma Membrane Remodeling to Drive Tumor Growth, Generating an Actionable Dependency across Cancers EGFR PC LPCAT1 PMC7442051__F2 Figure depicts the autophagy regulators in regard to lung injury EGR1 ATG3 ATG12 BNIP1 ATG14 MTOR ATG5 PMC3934442__F5 Rho/Rho-Associated Coiled-Coil Forming Kinase Pathway as Therapeutic Targets for Statins in Atherosclerosis ROCK2 ROCK1 FHL2 ARHA PMC2633249__F3 Enzymatic function of multiple origins regulates the progression of colorectal cancer and the development of metastases BAD AMFR RAC1 PMC9068331__F2 Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability RHEB TRIL KIT PTEN RHO DEPTOR PMC9675141__F6 Antioxidant and anti-inflammatory activities of Centratherum anthelminticum (L.) Kuntze seed oil in diabetic nephropathy via modulation of Nrf-2/HO-1 and NFKB pathway BAX COX1 KEAP1 PMC5118085__F1 Notch signaling and alloreactivity ADAM10 NOTCH2 NOTCH3 NOTCH1 PMC9032508__F6 Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia HEL-S-62p HEL-S-133P C2 PMC3365799__F13 Major steroidogenic pathways in the three zones of the human adrenal cortex POR PAPSS2 SULT2A1 PMC5089941__F1 Mechanism of appetite regulation by the hypothalamus and peripheral tissues TRH CCK PYY CRH POMC MC4R NPY AgRP PMC3660828__F3 Components involved in translocation of phospholipids to and within mitochondria of yeast PGS1 PHB2 PGP CDS1 PC ATP23 PMC9032508__F2 Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia TSC2 ATM HIF1A PMC12154365__F6 Dual functions of EBF1 and its molecular regulatory network across multiple tumor types FBN1 HEY2 SOX2 G3BP2 PMC3383335__F2 SnoN Signaling in Proliferating Cells and Postmitotic Neurons DCX FOXO1 APC PMC12154365__F4 EBF1-mediated oncogenic mechanisms and regulatory network in BCa RBP7 NR2F1 PMC6521028__F8 Mechanism of PDCoV N protein interfered with the type I IFN response MAVS STAT2 HEL-S-69p IRF3 IRF7 TRAF3 JAK1 PMC2936760__F5 Signaling pathways described in ARPE19 cells CD36 PMC6500894__F2 Mesenchymal stem cells and their mitochondrial transfer: a double-edged sword NTS TNFAIP2 MSC PMC3660828__F2 Biosynthetic pathways of aminoglycerophospholipids PSD PEMT PC PMC4002809__F2 Current model for NFKB signaling pathway induced by C-type lectin receptors SAP130 SYK BCL10 PLCG2 CARD9 PMC8346978__F2 Molecular Pathogenesis of Psoriasis and Biomarkers Reflecting Disease Activity NLRP3 CCR2 ATM CCL2 TNF PMC270001__F2 Chemoresistance in Human Ovarian Cancer Cells BAX FAS CDK6 MDM2 CDK4 PMC2907250__F1 The three top ranked pathways in this study.‘Syndecan-1-mediated signaling events’ from PID; (B) ‘Signaling of hepatocyte growth factor (c-Met)’ from BioCarta; (C) ‘Growth hormone signaling pathways’ from BioCarta HRAS HPSE CRK TG JUN HGF PTPN11 PTEN CASK hEMMPRIN GRB2 PMC7016889__F1 General view of glycolysis PGAM1 HEL-S-68p HEL-S-162eP WAS HEL-S-87p PMC3729218__F4 Mutations causing susceptibility to intestinal inflammation EREG AQP3 EGFR MUC2 TLR9 YIPF6 AREG XBP1 PMC8997157__F4 PI3K/AKT Signaling Tips the Balance of Cytoskeletal Forces for Cancer Progression CDC42 PTEN PMC6186653__F2 Schematic diagram showing both the pathway for VEGF upregulation though EGFR/ALK gene alteration and its immunosuppressive role ALK EGFR MTOR PMC10377462__F10 Molecular Basis of Transglutaminase-2 and Muscarinic Cholinergic Receptors in Experimental Myopia: A Target for Myopia Treatment MAPK14 HRH1 EGF CDKN2A F2 TGM3 ADRB2 MMP3 YBX1 MAPK8 BCL2L11 MAPK3 PMC6016172__F2 Pathway linked to ER stress ATF4 IRS1 PMC11063913__F1 Regulatory mechanisms of cytokines in male sex determination in mice DMRT1 WT1 SF1 SOX9 SRY FGF9 AMH GATA4 SOX8 PMC12059313__F8 Isobutyrate confers resistance to inflammatory bowel disease through host–microbiota interactions in pigs NLRP3 AHR PIGS FOXP3 MYD88 PMC2833311__F6 Signaling pathways involved in Alpha-TEA-induced apoptosis in human ovarian cancer cell lines ERBB3 BAX FAS ERBB2 PMC6471306__F1 Type I and III interferon production following pathogen sensing STAT1 IFNLR1 STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IRF7 PMC3292751__F3 Regulation of mammalian mitophagy OPA1 PARL MFN1 MFN2 PMC4249724__F4 Müller glia cell reprogramming and retina regeneration STAT3 HBEGF IGF1 CTNNB1 PMC317036__F5 Model showing the possible relationship of dTOR with the insulin pathway PTEN EIF4E PMC4490668__F1 Multifactorial pathogenesis of primary Sjögren’s syndrome: interferons as culprits in the self-amplifying pathogenic loop TH RO60 PDC TLR7 SSB PMC11063913__F2 Regulatory mechanisms of WT1 in sex differentiation CDC42 WT1 SF1 SOX9 RHO AMH PMC11063913__F4 Regulatory mechanisms of SOX9 in sex differentiation SOX9 SRY FGF9 PMC8076851__F4 Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice LEP FFAR3 CD36 TRPM5 LEPR POMC PLCB2 TAS1R2 TAS1R3 FFAR2 FFAR1 PMC11063913__F5 Graphical summary During sex determination in the male embryo, the expression of numerous cytokines at specific times and spaces act together to regulate the lineage differentiation of Sertoli cells DMRT1 PGC WT1 SF1 SOX9 SRY FGF9 AMH GATA4 PMC9587054__F4 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions STAT3 OSBPL2 CXXC5 ADD1 NOTUM LRP5 UCP1 LRP6 RYK ARHA CTNNB1 PMC9603842__F4 Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review STAT3 FAS CASP8 CASP3 FADD PMC9587054__F5 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions BMP4 FASN POMC UCP1 FABP4 NPY AgRP SIRT1 PMC6909968__F6 Proposed schematic model illustrating the role of SLCO4A1-AS1 in regulating CRC by EGFR/MAPK signaling pathway MAP3K1 EGFR BRAF KRAS PMC9587054__F6 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions CCK PYY POMC MC4R MC3R MC2R NPY ARC AgRP PMC11628531__F1 LAG-3 signaling pathway and its ligands in tumor immunity ADAM17 FGL1 APC ADAM10 LAG3 PMC9587054__F3 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions ADRB3 GDF3 PGC ALK GDF15 POMC UCP1 NPY GFRAL AgRP RET pp6425 PMC9243884__F3 IL-1 family of cytokines and receptors in pathogenesis of COVID-19 IL33 COPA PMC9256571__F1 Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease CXCL9 CXCL11 CXCR3 CCL22 CXCR6 CCL25 CCR5 CCR6 CXCL16 CCR4 CXCL10 CCL20 PMC4078240__F4 Map of SCAP/SREBP Transcriptional Control of Cholesterol and FA Biosynthesis ACLY HMGCS1 ELOVL3 ACACB GPAM SCD FASN GSK3B FDPS ACACA ACSS1 INSIG1 PMC8301368__F7 Platelet-Activating Factor Acetylhydrolase Expression in BRCA1 Mutant Ovarian Cancer as a Protective Factor and Potential Negative Regulator of the Wnt Signaling Pathway BRCA1 GSK3B CTNNB1 PMC8301368__F8 Platelet-Activating Factor Acetylhydrolase Expression in BRCA1 Mutant Ovarian Cancer as a Protective Factor and Potential Negative Regulator of the Wnt Signaling Pathway GSK3B MMP2 ARHA MMP9 SRC PMC8648465__F7 Network Pharmacology-Based Analysis of the Underlying Mechanism of Hyssopus cuspidatus Boriss. for Antiasthma: A Characteristic Medicinal Material in Xinjiang MAX JUN TRADD C13orf34 MX1 TNF PMC7003858__F4 Signaling in T‐cell activation and PD‐1–mediated suppression ZAP70 APC ITK LCK PMC9298327__F1 Expression, prognostic significance and therapeutic implications of PD‐L1 in gliomas ZAP70 CD80 APC PTEN LAG3 PMC6621970__F10 Schematic highlighting the signaling cascades that are dependent on erbB4 in MPNSTs STAT3 NRG1 RAF1 SOS1 ERBB4 GRB2 MTOR PMC3718675__F3 Axis of ageing: telomeres, p53 and mitochondria IGF1 FES MTOR SIRT1 PMC3524155__F1 Sensing the enemy NOD2 NOD1 PMC8099789__F1 ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients ATR ADAM17 PLG ACE2 PMC2594010__F2 Regulation of metastasis in colorectal adenocarcinoma: A collision between development and tumor biology APC GSK3B WNT1 MYC CCND1 CTNNB1 PMC3932427__F1 Schematic showing the interference of Hepatitis C virus in the insulin signaling pathway RHEB TSC2 TSC1 SOCS3 MTOR PMC5367255__F8 Model depicting role of miR-432 in regulating myogenesis MYOG E2F3 MTOR PMC7922006__F8 CASR-ROCK-YAP1 signaling pathway in tumor parathyroid cells LATS1 CASR LATS2 ARHA YAP1 PMC3131157__F6 Manipulation of plant cell ubiquitin pathway by bacterial pathogens CERK BAK1 PMC6652118__F1 RIG-I/MDA5 signaling pathway RIG-I and MDA5 are first activated by recognition of PAMP dsRNA, which causes them to interact with MAVS TBK1 MAVS IRAK1 IRF3 IRF7 PMC9520222__AF1 Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway CDC42 COL6A1 COL1A1 SOX9 COL3A1 PMC7317989__F1 Model illustrating the steps of EBV infection of epithelial cells EPHA2 NRP1 CR2 PMC7553088__F4 Chemokine-like factor 1: A promising therapeutic target in human diseases BAX CCR4 VCAM1 PMC7553088__F5 Chemokine-like factor 1: A promising therapeutic target in human diseases STAT3 CCR4 MYC CCND1 PMC6886211__F8 PLNet2: LocPL pathway reconstructions (first 100 paths) STAT3 SYK RAF1 SHC1 ITCH EGFR JAK3 IGF1R ATF2 FGFR2 BTK FYN EPOR IL2 APP SRC NMI LEPR TRIP10 PTPN11 KIT NR3C1 HGS CBL c-fgr FOXO3A CDC27 JAK1 LYN TYK2 PMC9409040__F7 Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer ATR DLAT PPP5C CHEK1 ATM E4F1 PMC2153443__F8 TGFB SIGNALING BY PROINFLAMMATORY CYTOKINES IN ARTICULAR CHONDROCYTES TF IL1B PMC7154099__F1 Schematic diagram depicting the regulation of osteoblastic-specific genes expression by lithium through activation of three major signaling pathways, including the canonical Wnt/Beta-catenin, PI3K/Akt and BMP-2 signaling pathways SMAD1 SOST DKFZp781O1323 APC GSK3B LRP5 LRP6 NFATC1 RUNX2 CTNNB1 PMC8394324__F3 Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer BAX FAS MCL1 TNF APAF1 FADD PMC7228650__F2 Epigenetics of colorectal cancer: biomarker and therapeutic potential MMP7 EGF EGFR SMAD2 APC LRP5 SMAD4 PTEN HIF1A MYC CTNNB1 PMC8394324__F4 Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer RHEB TSC2 TSC1 PTEN PMC10987302__F1 Crosstalk between lncRNAs and Wnt/Beta-catenin signaling pathways in lung cancers: From cancer progression to therapeutic response HMGB1 AXIN2 SOX4 WNT2B CTNNB1 PMC4522946__F6 Apoptotic signaling pathway induced by Licochalcone-A in head and neck squamous carcinoma FaDu cells BAX BAD BCL2 FADD PMC10487929__F9 Network connectivity pathway map of the downstream effects of simulated SARS-CoV-2 infection on the predicted activity of the NISP SNCA IRF7 PTGS2 IL6 CCL5 HLA-DRB5 TNF CCL2 IFNG STAT1 HLA-DRA ACE2 IL1B PMC4447643__F9 Schematic diagram showing the modulation of insulin-mediated glucose uptake in muscle cells by CRFR2 signaling pathway MTOR IRS1 PMC4238866__F10 Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae MAF1 RRN3 TPK1 PMC4298491__F2 PI3K in the biology of B cells CD40 CD79B SYK BTK BCR PLCG2 CXCR5 CD19 LYN MTOR PMC4298491__F3 Signalling of the PI3K/AKT/mTOR pathway and relevant drugs that target each of the components of the pathway BCR EGFR PTEN PMC10487929__F6 Influence of COVID-19 on SNCA expression and PD SYN2 TREM1 CCK PLSCR1 CHL1 CCL5 CCL2 IFNG STAT1 HLA-DRA CHRNA6 CD74 MX1 ISG15 ACE2 IL1B AIP SNCA NTRK2 RBP4 IRF7 PTGS2 RSAD2 IL6 TNF ID1 EMP1 SYN1 RET PMC10487929__F7 Network connectivity pathway map of ACE2’s downstream effects of simulated SARS-CoV-2 infection on predicted activity of SNCA and PD IFNG SNCA CCL5 ACE2 IL1B PMC10545783__F1 Bacterial PSAs transduce signals through innate receptors to modulate immune responses TLR1 TLR4 IRF3 MYD88 PMC8073160__F4 Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review SOST BMP2 RUNX2 FGF2 FGF23 PMC8073160__F1 Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review SOST MSC PTH TNF PMC4710174__F1 HSC aging and senescent immune remodeling CDC42 CXCL12 SATB1 CTNNB1 PMC2151350__F2 Model for renal pathology in Dent's disease (due to a loss of ClC-5) The small peptide PTH (parathyroid hormone) and various forms of vitamin D (VitD; bound to their binding protein) pass the glomerular filter into the early proximal tubule (A) NR1i1 TRPV5 PTH PMC6623175__F9 Model proposed to explain why BDNF fails to regulate local translation in the hippocampus of Ts1Cje mice DSCAM FYN LIMK1 PLG ARC MTOR BDNF HOMER2 EIF4E PMC9692093__F2 RNA modification in the generation of acquired drug resistance in glioma ADAR GM2A IGF2BP3 ZNRF3 EZH2 GSC MYC SOX21 PMC4704338__F1 Activation of the Notch signaling pathway EGF IGF1R PMC2649208__F2 Molecular interaction map displaying the functional interaction of genes in the MEK/ERK output profile with established roles in ERK signaling ETV5 EGR1 SPRY4 DUSP4 MYC FOS SPRY2 CBL PLK3 FOSL1 ETV4 GRB2 CCND1 PMC6966515__F2 Schematic showing the numerous cellular events which are altered by viral proteins in transformed cells (see key bottom right corner) CDC42 CDC20 APC RHO MTOR FADD PMC1599931__F1 Phosphatidylinositide 3′-OH kinase/Akt/mTOR signaling pathway RHEB EIF4E PMC3228224__F1 Pathways involved in mTOR signaling.Abbreviations: mTOR, mammalian target of rapamycin; PI3K, phosphoinositide 3-kinase; TSC, tuberous sclerosis.Adapted from: Kopelovich L, Fay JR, Sigman CC, Crowell JA TSC2 TSC1 MTOR PMC4793911__F2 Major cellular mechanisms controlling contraction in gastrointestinal smooth muscle cells GAA GCA NACA2 ARHA PMC9505944__F2 Controversial Role of LPS in Platelet Activation In Vitro TIRAP TLR4 CD14 IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC514817__F2 Cytokine production by MAPK pathways CDC42 JUN GCK PMC9505944__F3 Controversial Role of LPS in Platelet Activation In Vitro TIRAP TLR4 CD14 IRAK1 IRAK2 IRAK4 MYD88 PMC7919585__F2 CoVs on mitochondrial dynamics and autophagy as a quality control axis and the regulatory effect of melatonin.Coronaviruses impacts mitochondrial dynamics and mitophagy HTRA2 ATG10 BAX ATG3 PINK1 FIS1 ATG12 OPA1 ATG14 ATG5 DIABLO PMC8316339__F5 Apicoplast isoprenoid biosynthesis is critical for P. falciparum survival of febrile temperatures RAB11B RAB5C IPP PMC514817__F4 Interaction of stress and inflammatory responses JUN HSF1 IL6 FOS PMC4488779__F2 Proposed model of the vitamin D-dependent antimicrobial pathway NR1i1 CD40 DBP TLR1 NOD2 HAMP PMC8957809__F8 Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3Beta-Mediated Keap1/Nrf2/HO-1 Signalling Pathway KEAP1 GPX4 GSK3B PMC5435544__F4A Signal transduction pathways and targets in paediatric Burkitt lymphoma HEL-S-31 CD80 MAPK11 RAF1 TNFRSF1A TNFSF6 MAPKAPK2 MAPKAPK3 IRAK1 MAPK9 IL1A TRAF6 IRAK4 STAT1 IFNAR2 IKBKB IFNAR1 NFKBIA MAP3K7 APP MAP2K1 PMC7905385__F1B Immune response, immunopathology, and mechanism of action of immunotherapeutics for SARS-CoV-2 infection (intracellular) AAK1 TMPRSS2 TLR3 COX2 TLR9 TLR7 HEL-S-11 CXCL2 IL1B PMC6014315__F1 Impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment TSC2 TSC1 INPP4B PTEN PMC11121230__F2 SHIP1 and SHIP2 in the PI3K/AKT signaling pathway (created with BioRender RHEB TSC2 TSC1 PDPK1 PTEN PMC5929164__F5 Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis LATS1 NEDD8 LATS2 NF2 PMC3060878__F5 FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways FGF8A CYP8B1 CYP7A1 FGF21 FGFR4 CYP7B1 CYP27A1 PMC8125511__F5 Broadly Antiviral Activities of TAP1 through Activating the TBK1-IRF3-Mediated Type I Interferon Production TBK1 STAT1 STAT2 IFNAR2 IRF9 IFNAR1 IRF3 TAP1 JAK1 TYK2 PMC8615865__F3 Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment RAC1 PMC4839647__F3 A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer ACLY SMS ACO2 FASN SMOX ACACA CS AMD1 SDHD SDHA ACACB SUCLA2 SRM SUCLG2 SDHC PMC6924635__F1 Exosome biogenesis and major exosomal cargoes CD81 RAB27A RAB27B CD9 CD82 CD63 PMC7563377__F8 Model illustrates targeting of the hedgehog (Hh) signaling using PSMA aptamer conjugated PBM-NPs inhibits prostate cancer tumorigenesis SUFU PTCH1 SHH SMO PMC4222901__F2 Cytoskeletal modulation and signaling CDC42 NCK1 VAV2 EGFR TARP ARF6 AHNAK RAC1 PMC7364818__F7 Differentially expressed genes in the PAI-1 KO injured tendon that contribute to the activation of the canonical PTEN Signaling pathway at 2-weeks post injury MAST2 BAD CASP3 PTEN PREX2 PMC9279758__F6 CD44 potentiates hepatocellular carcinoma migration and extrahepatic metastases via the AKT/ERK signaling CXCR4 axis CD44 CXCL12 CXCR4 PMC4539069__F1 Proposed model for the complex cross talk between various receptors and mediators in early phase response in allergic rhinitis NGF CCR2 TRPV1 CCR3 PMC3693108__F1 Therapeutic molecular targets for endometrial cancer EGFR PTEN MTOR FGFR2 PMC6077868__F7 TGFB-dependent signaling implicated in fibrosis process SPHK1 ARHA MTOR PMC3162305__F4 Oncostatin M signaling pathway MT2A TIMP3 OSM MAK OSMR GRB2 PMC2533092__F1 Metabolic pathways for the synthesis of phospholipids and neutral lipid classes in S CDS1 GPT2 PC PMC3648340__F1 Iron and Diabetes Risk TF TFR2 HEPH FES HFE HFE2 PMC3571654__F1 shows the effects of osteoblast-secreted osteocalcin on glucose homeostasis and its novel role in regulating testosterone production in the leydig cells STAR CYP11A1 ATF4 RUNX2 PMC6034278__F5 LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs IFI44L PTX3 TREM1 IFI44 IRF7 OAS2 PMC126023__F7 Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae OGG1 RAD1 PMC3258305__F2 The Long History of Iron in the Universe and in Health and Disease TF STEAP3 ABCB7 PMC11003173__F10 Hypothetical modules and cold response pathways of eggplant MYB ERF CBL PMC9086029__F6 Microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma TRIM13 CD226 TXNIP ZER1 SREK1 ZNF610 EGLN3 HUWE1 MAPK14 FRMD6 DNAJB9 CRY2 GPR75 TRIB1 WAS RRP7A ANTXR2 ZNF460 CDH8 TSPAN1 METTL15 ZNF488 TMEM178B FNBP1 VPS37A AAR2 TMEM170A CYP2A7 SLC25A17 C10orf67 EXOC5 MAGEB4 ZNF277 ZNF275 NWD1 HMGXB4 ZNF429 XRRA1 ARSK ANP32B RBBP9 ATP9A ARHGEF33 CHRM2 NBPF10 TMEM184A PKDREJ PACS2 LHFPL2 FBXL16 OCIAD2 HNRNPA1L2 SP9 TCF23 CCT4 ATXN2L CHMP3 ZBTB18 UGT2A1 COL1A1 MYZAP LSM11 YAF2 ARL11 DNPEP CFL2 B4GALT1 INMT AKAP8 BACE2 DOHH BTN3A3 CELF2 CMBL SIRPA VAT1 PMC9086029__F7 Microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma SLC40A1 ARPC2 NTRK3 BBC3 WNT9B MTOR WNT2B HUWE1 MYD88 FOXM1 ZBTB2 CDH2 PTGER2 GPC1 SP1 PQBP1 SCAMP3 DVL2 IL6 SAE1 NFYB CREBBP ZNF783 UST MAT1A ZNF730 RPL17-C18orf32 PMC3651307__F1 Toll-like Receptor (TLR) Signaling Pathways TIRAP TICAM2 IKBKE TLR9 IRAK1 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TICAM1 TLR4 TLR8 TLR7 PMC5901872__F2 Expression difference of metabolic genes between the GX stage and X stage in BSGX001 and XH7 ACO2 COX10 COX5A HEL-S-4 COX17 PMC3792371__F1 TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma ZAP70 IFNG TH FYN IL4 DLD ITK LCK PMC9183106__F6 Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway BAX BCL2 MDM2 PMC8505060__F9 Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway CORT CRH BDNF PMC4766714__F9 Incomplete lung recovery following sub-acute inhalation of combustion-derived ultrafine particles in mice CCL22 HEL-S-62p CXCL5 CD14 EHF HEL-S-25 CXCL2 AHRR CD133 TNF CXCL17 CCL28 LCN2 CCL20 CP ELF3 PF4 PMC3185763__F1 Extrinsic (death receptor-mediated) and intrinsic (mitochondria-mediated) pathways that lead to apoptosis of HIV infected helper T cells BAX FAS CXCR4 FADD PMC442148__F2 Protein interaction map around some selected baits in the TGFB pathway LAPTM5 DAZAP2 NUP155 ST13 PSG2 DKFZp781O1323 CANX GOLGB1 PPP1CC SMAD2 FAF1 SMAD4 FLNA CTNNB1 ERBIN TRAF4 PIG59 NCOR1 SOX7 ETS2 SOX13 SP1 RNF11 RPS27A EEF1G PPP2R1A SKI SMURF1 SNIP1 SMURF2 PPL PMC4589430__F2 Immunosuppressive and tumor-promoting functions of TAMs and MDSCs in HCC STAT3 CD33 CD14 CD163 CD68 PMC5596246__F1 Caspases in extrinsic and intrinsic apoptosis BAX TRADD APAF1 FADD PMC5596246__F3 Caspases control the cGAS-STING signaling pathway BAX TBK1 CGAS IRF3 PMC5596246__F4 Caspases regulate RLR and TLR antiviral signaling TBK1 TRADD MAVS TLR9 IRF3 IRF7 MYD88 RIPK3 TRIM25 TLR3 TLR8 RIPK1 TLR7 FADD PMC6245571__F2 Species-Specific Transcriptional Regulation of Genes Involved in Nitric Oxide Production and Arginine Metabolism in Macrophages SLC3A2 ASS1 SLC7A1 TASL SPR ASL PTS OTC ARG1 ARG2 PMC7411521__F4 Apoptotic signaling through membrane (lipids)-mediated spontaneous activation of Bax/Bak BAX CASP9 BAD CASP8 CASP3 BMF HRK BIK FADD PMC3056121__F1 Regulatory natural autoantibodies to apoptotic cells: Pallbearers and protectors TLR9 PC TLR7 ACR PMC8878972__F7 Zika Virus Infection of Sertoli Cells Alters Protein Expression Involved in Activated Immune and Antiviral Response Pathways, Carbohydrate Metabolism and Cardiovascular Disease ACOT13 SLC39A14 CSF1 PLSCR1 FABP1 CXCL8 ST3GAL1 MANBA PLCB3 OAS1 DCN APOD SERP1 PARP14 SLC2A3 PLA2G12A HEL-S-30 COL2A1 CD44 FGF7 PGAM1 GNS HEL-S-68p MTMR2 GYS1 FOXO3A HAS2 LYN HEL-S-87p PMC2919952__F1 Scheme of basic metabolic pathways and energy conservation in C TH ETFA ETFB PTS PMC6589702__F8 Proposed model of regulation of endothelial barrier function by FBXW7 FBXW7 HMGCR RHOB SQLE LDLR PMC10502988__F8 Following CARNIVAL analysis (or re-uploading previous results) the user can carry out pathway enrichment and visualisation on the inferred signalling network MAX PIK3CA EGR1 ERBB4 EGFR PIK3CD SOX2 SREBF2 SPI1 NR2F1 MAPK3 NR2F6 RARA FOXO4 FOXO1 FOXO3A RELA HSF1 ERBB2 EP300 MAP2K1 ZBTB16 CREB1 RET PMC5932261__F7 Mechanical strain induced phospho-proteomic signaling in uterine smooth muscle cells HEL-S-28 ARHA PMC7308544__F2 The metabolic interrelationships between low-density lipoprotein (LDL) subfractions and their hepatic precursors LPL TG APOB PMC5522095__F8 Naoling decoction restores cognitive function by inhibiting the neuroinflammatory network in a rat model of Alzheimer’s disease CGA NLRP3 TLR4 PMC9084694__F4 Single‐cell profiling of transcriptomic changes during in vitro maturation of human oocytes HEL-S-22 CHODL RBM4B ACSL5 TMCC3 ST7 MYH4 LRAT ARHGAP30 TUBA2 TYRP1 CDKN2D IL15RA TMEM171 ID3 FGFR2 EPHB2 CDKN1A CD63 SMARCA4 PMC5243144__F4 Schematic summary of metabolic pathways disturbance caused by suppression of pyruvate carboxylase in MDA-MB-231-derived cell lines FAS GLS PC ME1 HEL-S-26 PMC6165719__F1 Signaling pathways underlying synaptic plasticity in striatal direct pathway spiny projection neuron CDK5 PDE1B PC PMC9084694__F2 Single‐cell profiling of transcriptomic changes during in vitro maturation of human oocytes NOS2 VASP ID2 H2AC20 MNX1 HIF1A H1-2 PMC11276987__F10 Lipids as signaling molecules that regulate metabolism MAP3K7IP1 TLR4 IRF3 SRC IRS1 MYD88 PMC7418812__F9 Model for glucose regulation ovarian primordial follicles activation via the AMPK/mTOR signaling pathway LATS1 MTOR PMC4179923__F6 Tazarotene Induces Apoptosis in Human Basal Cell Carcinoma via Activation of Caspase-8/t-Bid and the Reactive Oxygen Species-Dependent Mitochondrial Pathway FAS FADD PMC2954288__F10 Hypothetical model for SWAP-70 function in mast cell FcERI signaling LAT IL4 PMC5774249__F8 Cellular model of insulin (and leptin) signaling via TRPC5 channel activation in POMC neurons STIM1 POMC TRPC5 SOCS3 PMC3670000__F2 Signaling pathways used by GH to regulate growth and metabolism STAT3 STAT1 GRB2 MTOR SRC PMC3670000__F3 Signaling pathways activated by E2 and its crosstalk with GH SOCS2 GHR PMC4933215__F2A Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities PIK3R3 PIK3CD PIK3R2 PIK3R1 HIF1A IGF1R MTOR IFNG TFRC PLCG2 TLR4 RPS6 EIF4EBP1 VEGFA VHL EIF4E RBX1 CDKN1A CAMK2D NFKB1 CDKN1B ERBB2 CREBBP BCL2 MAP2K1 CAMK2G PMC10948231__F2 PPARG and the PTEN-PI3K/AKT Signaling Axis May Cofunction in Promoting Chemosensitivity in Hypopharyngeal Squamous Cell Carcinoma PPARG PIK3CA AKT3 PTEN PMC5249061__F6 A Circulating microRNA Signature Predicts Age-Based Development of Lymphoma JUN HEL-S-162eP RIDA SMURF2 MYC PMC6770393__F2 Key metabolic remodeling and potential therapeutic targets in glioblastoma (GBM) TES GLS HEL-S-133P HK2 EGFR PTEN LDHB MTOR MYC ACSS2 GLUD1 PFKP BCAT1 PMC5253647__F6 SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers AURKA HCTP4 SMARCA4 PMC7550790__F1 Involvement of unfolded protein response (UPR) in neuropsychiatric disorders EIF2A BDNF XBP1 PMC2998292__F1 Estrogen and Tamoxifen Metabolic Pathways depicted at the genomic level CYP2B6 CYP17A1 PGR CYP1B1 CYP3A4 PMC3851681__F1 Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection EBI3 IL23R IL12RB1 PMC2998292__F2 Pathway Analysis Models for the Tamoxifen (TAM) Pathway tested with data from the Placebo (P) and Tamoxifen (T) arms CYP2B6 CYP2C19 CYP2C9 CYP3A4 PMC6246015__F2 Signaling pathways subverted in T-cell oncogenesis STAT3 ZAP70 LAT CARD11 VAV1 MTOR ARHA MYC PTPN6 RAC1 ICOS FYN BCL10 RELA BCL2 GRB2 JAK1 LCK PMC9696358__F2 Methylglyoxal in the Brain: From Glycolytic Metabolite to Signalling Molecule TRPA1 CASP3 APP PMC8759917__F9 Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPARA Signaling Pathway HEL-S-103 SLC10A2 EHHADH ELOVL2 CYP7A1 UNG AQP8 PMC7870803__F10 Diagram depicting the molecular regulation mechanism of the NEAT1/miR-129-5p/PEG3 axis in liver fibrosis of mice with NASH through the NFKB signaling pathway AGO2 PEG3 PMC7143872__F1 Impact of physical activity on bone health SOST RUNX2 IL1B PMC10242642__F1 SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia CDA RRM1 RRM2 CMPK1 DCTD EFS PMC4622586__F1 The classical complement pathway initiated by mAbs and its inhibitors C6 CD59 FH C7 HEL-S-62p VTN CD46 CD55 C4A PMC8872331__F3 MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma RB1 NF1 PDGFRA PTEN MDM2 PMC8872331__F4 MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma TIMP3 ADAM17 RECK MMP3 MMP9 PMC9866016__F10 Alfalfa Xeno-miR168b Target CPT1A to Regulate Milk Fat Synthesis in Bovine Mammary Epithelial Cells CD36 ACADVL ACADL CPT2 CEBPB CPT1A ACADM PMC5418219__F2 Roles and modulations of toll-interacting protein (Tollip) in acute and chronic inflammation TLR4 IRAK2 IRAK4 PMC7604396__F1 KRAS4B domain organization and RAS signaling pathway at the cell membrane EGF HEL113 SOS1 EGFR GRB2 KRAS PMC7313057__F1 Bone metastatisation process CDH2 SOST LOX BMP7 PMC7570423__F1 Immunity, endothelial injury and complement-induced coagulopathy in COVID-19 TMPRSS2 HEL-S-69p ACE2 PMC3988238__F1 Dendritic cells initiate T cell immunity in the lymph nodes CD40 STAT3 CD80 STAT4 FOXP3 GATA3 PMC3989954__F1 Crosstalk between mechanistic target of rapamycin signaling pathway and colorectal oncogenic pathways RHEB TSC2 TSC1 IGF1 SGK1 EGFR PTEN RHO MTOR EIF4E PMC7570423__F3 Immunity, endothelial injury and complement-induced coagulopathy in COVID-19 TMPRSS2 C6 VWF C7 C9 ACE2 PMC12039146__F7 Schematic diagram of lipid metabolism and its crosstalk with other metabolism pathways TG GPAM BDH1 SLC2A4 DGAT2 HK2 FASN PDGFC FNIP2 MTOR PCK1 PMC8155903__F5 Differential mRNA and miRNA Profiles Reveal the Potential Roles of Genes and miRNAs Involved in LPS Infection in Chicken Macrophages CD40 TIRAP TLR3 TLR9 CD14 IRF3 MYC LBP CD6 FADD PMC11486635__F5 IRFs Respond to TLR Signaling and Participate in the Expression and Function of IFNs TBK1 TIRAP IRAK1 TRAF3 TRAF6 IRAK4 MYD88 IFNK STAT1 IFNGR2 SLC15A4 IFNGR1 IFNLR1 STAT2 IRF9 IRF1 IRF3 IRF7 IRF4 IRF8 CXCL10 TASL IFNAR2 IRF2 IFNAR1 JAK1 TYK2 PMC9201425__F3 Antimicrobial Peptide Expression at the Ocular Surface and Their Therapeutic Use in the Treatment of Microbial Keratitis NR1i1 EGFR CD14 TRAF6 FOS IRAK4 PMC11486635__F3 Apoptosis by IRFs BAX TBK1 IFNGR1 MAVS STAT2 OTULIN IRF1 IRF3 IRF7 TRAF3 IRF4 TRAF6 STAT1 IFNGR2 IFNAR2 IFNAR1 JAK1 APAF1 TRAF2 TYK2 FADD PMC4386406__F2 The phosphoproteomics data CDC42 BAD SHC1 SOS1 LAT VAV1 MTOR FLNA RAC1 SET DOK1 PLCG1 BCL10 NFKB1 ITK GRB2 CREB1 LCK PMC11035723__F1 Early dynamic changes to monocytes following major surgery are associated with subsequent infections CD80 CCR2 IL7R CCR4 CTLA4 PMC4925820__F4 The hunger signaling pathway constructed in the IPA program colored according to genes correlating with circulating leptin levels TH RARA PYY PMC4925820__F6 Genes involved in circadian rhythm pathway constructed in the IPA program colored according their correlation with circulating levels of tumor necrosis factor alpha (TNFA) PPARG LEP MTUS2 STRC THRAP3 MTSS1 ACACA THRA RORA BTG1 CEBPG RETN ATF4 NR1A2 TEF HTT CEBPE JUN BATF PER2 FASN NCOA1 LBR NPY2R ATF3 RORC NR1C1 CRYZL1 IGF1 PRL RXRA DDIT3 NFATC3 PMC4741457__F9 Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination LNX2 NUMB MYC AXIN2 CTNNB1 PMC4480235__F5 Signaling by myeloid C-type lectin receptors in immunity and homeostasis RAF1 KSR1 ARHA TNF PMC10894496__F8 Optimized New Shengmai Powder modulation of cAMP/Rap1A signaling pathway attenuates myocardial fibrosis in heart failure STAT3 RAP1A CCND1 PMC8992440__F1 Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review UGT1A1 APC C8orf85 ABCG2 ABCC2 ABCB1 PMC6309125__F1 Hippo Pathway and its canonical upstream regulators FAT4 RASSF6 RASSF2 RASSF1 RASSF4 FJX1 TEAD4 MOB1A FRMD6 MOBKL1A TEAD2 TEAD3 FAT1 AJUBA FAT2 FAT3 PMC5095301__F7 Schematic diagram illustrating inhibition of HMGB1-TLR4 signaling pathway by dexamethasone in renal ischemia reperfusion injury HMGB1 TLR4 IL1B PMC6309125__F2 KIBRA/Hippo pathway as a shunt of stressful input MOB1A MOBKL1A AJUBA RHO PICK1 PMC4480235__F2 Signaling by myeloid C-type lectin receptors in immunity and homeostasis RAF1 NLRP3 COX2 RELB EGR2 TNF IL1B CARD9 PMC9605584__F1 DPP3: From biomarker to therapeutic target of cardiovascular diseases NQO1 DPP3 ACE2 PMC11853993__F7 CD73 downregulated expression induced by TgROP18 and its consequences on dMφ dysfunction EBP ARG1 PMC8561419__F3 Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth MADD KYNU PTS PMC5282447__F2 Summary diagram of JAK/STAT and MAPK signal transduction CNTFR CNTF EGF HBEGF GFAP SHC1 CEND1 JAK1 FGF2 PMC3464875__F7 Signaling involved in MUC4 expression upon Nicotine, IFNG and Retinoic acid stimulation STAT3 STAT1 PMC9688160__F1 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders LATS1 HEL-S-31 LATS2 MAP4K3 AXL TEAD2 MAP4K1 TEAD3 MAP4K2 RHO SRC TEAD4 PMC4631799__F2 ERBB signaling pathway is highly activated in AA PCa specimens EGF JUN BAD TGFA ERBB4 MCL1 MTOR SHE MYC CRK STAT1 HBEGF BTC ERBB2 ITPR2 GRB2 SRC UNK PMC4791944__F1 Longevity: Mapping the path to a longer life ETV6 INSR IGF1R PMC9688160__F4 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders LATS1 LPA PMC2912833__F4 Generation of a biological network of genes of the most significant Canonical Pathways for the Il10-/- (EF·CIF vs HLA-DMB HLA-DRB1 CD14 B2M SOCS3 TNF SLC27A1 STAT1 HLA-G COX2 IFNAR2 IL18 NFKBIE ATF4 TAP2 NR5A2 FCGR2A PMC9688160__F2 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders TEAD2 TEAD3 APC NOTUM GSK3B LRP5 LRP6 TEAD4 CTNNB1 PMC3580589__F3 PTHrP signaling pathways during endochondral ossification BAP1 IHH RUNX2 RUNX3 PMC9688160__F3 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders HEL-S-31 MAP4K3 AXL MAP4K1 APC GSK3B LRP5 LRP6 MAP4K2 CTNNB1 LATS1 LATS2 HTT PMC3095674__F4 Procarcinogenic Effects of Cyclosporine A are Mediated through the Activation of TAK1/TAB1 Signaling Pathway ECSIT MAP3K7IP1 BCL2 TRAF6 SST PMC2912833__F3 Generation of a biological network of genes of the most significant Canonical Pathways for the EF·CIF (Il10-/- vs HLA-DMB ALDH2 HLA-DMA NR1C1 MAPK13 HLA-DOA CYP2C9 IRF1 ACADVL FABP4 MFNG PMC4286424__F2 Signal transduction pathway of bitter (T2R), sweet (T1R2/3), and umami (T1R1/3) GPCRs in type II taste cells of the tongue TRPM5 PLCB2 CALHM1 PMC10558709__F7 The main findings on HMEC-1 OGA OGT NQO1 PMC3551738__F3 Network analysis of known SLE-associated genes CRP FCGR2B TNFAIP3 PRDM1 BANK1 IRAK1 C1QB FCGR1A TRAF6 TNLG2B BLK C1QA C2 FCGR3A STAT4 C4B_2 TYK2 UBE2L3 FCGR2A PMC4424084__F1 RIG-I signaling pathway TBK1 RNF125 MAVS TRADD TRIM25 TANK IRF3 PMC11829561__F4 Metabolic reprogramming in the tumor microenvironment ASS1 ASL PMC9515385__F11 Scheme depicting the relevance of the PGD2 pathway in AD and its potential as an AD therapeutic target demonstrated by timapiprant (TIMA), a DP2 antagonist COX1 SOX2 MTOR PMC5214989__F2 Mitonuclear gene groups associated with disease in GWAS are significantly enriched for protein–protein interactions ICOSLG MRPS6 RAF1 GPX4 MCL1 CYCS PMAIP1 SLC22A4 ISL1 SUCLA2 MBP SAMM50 TRIB1 TOMM40 FHIT DCN IDE RPL27A FBN1 ACSL6 TMTC1 MSRA ACADS HAO1 APOE SNCA VEGFA MLH3 RPN2 NOA1 DLD BCL2 FDFT1 PSAP IREB2 SLC25A28 HEL60 TRIAP1 BAD ARPC2 NUBPL FADS2 TERT TSEN2 COMTD1 LYPLAL1 DPF1 XBP1 PRKCH MRPS22 INSIG1 RAB5B COX18 ALDH2 ACTA2 STK35 TFRC MRPL23 DDX1 PNKD LYRM4 DCLK1 MTHFD1L ATM HEL-S-15 ACTN1 BMS1 ANK2 HEL-S-67p ERBB4 BIN1 CTH BCL2L11 ANXA11 ALDH7A1 APCDD1 RHOB MOBP SH2B3 STMN2 COX11 PMC2867239__F2 The Primary Cilium as a Hedgehog Signal Transduction Machine SHH GLI3 PMC2867239__F5 The Primary Cilium as a Hedgehog Signal Transduction Machine SAG DYNC2H1 SHH SMO PMC8557709__F2 Hypothalamic endocannabinoids in obesity: an old story with new challenges CORT LEPR POMC NPY ARC AgRP PMC11780528__F9 Working model for the signaling pathway controlling the formation of SGs in yeast under 2-DG treatment ORM1 LSM7 ORM2 PMC2865336__F7 Role of Rad9A in the G2 decatenation checkpoint TOPBP1 ATR BRCA1 WRN RAD9A CCNB1 PMC7349363__F1 Notch signalling and strategies for pharmacological targeting of this pathway ADAM17 DLL4 ADAM10 FURIN HES1 PMC8233288__F2 Moonlighting of mitotic regulators in cilium disassembly VDAC3 AURKA CDC20 UBE2C BUB1B NEK2 HIF1A CPAP PLK1 NEDD9 NDEL1 KIF24 CCP110 C13orf34 CEP41 TTK NDE1 FZD1 HDAC6 MCC APC DVL2 PTP4A3 MAD2L1 NEK1 INVS FZR1 CDK5 PCM1 CALM1 PMC7997455__F1 Error-prone and error-free pathways of DNA double-strand break (DSB) repair BARD1 RAD51 DNA2 BRCA1 BRCA2 PALB2 PARP1 PMC6523720__F1 Epigenetic mediators involved in the establishment and erasure of histone post-translational modifications and DNA methylation, as described in the text HDAC3 HDAC1 HEL-S-92n HDAC10 HDAC8 HDAC5 HDAC9 HDAC7 CS HDAC2 HDAC6 PMC10251820__F1 Modern Management and Diagnostics in HER2+ Breast Cancer with CNS Metastasis BAD EGFR PTEN MDM2 GRB2 MTOR PMC3241604__F7 Proposed MAPK pathways and their inhibitors involved in EVT dysfunction during an inflammatory state TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC7754020__F8 Metabolic reprogramming of glycolysis and glutamine metabolism are key events in myofibroblast transition in systemic sclerosis pathogenesis TGFB1 KEAP1 SMAD2 SMAD4 PMC2832691__F3 Binding of Herpes Simplex Virus Type-1 Virions Leads to the Induction of Intracellular Signalling in the Absence of Virus Entry MMP7 MMP10 NFKB1 RELA IRF3 IRF7 SRC MYC REL BIRC3 PMC4647878__F4 Schematic mechanisms of action for drugs involved in the three arms of the TORAVA trial STAT1 STAT2 ELL MTOR JAK1 VHL PMC3808218__F1 PI3K/Akt/mTOR pathway RHEB TSC2 RICTOR TSC1 MTOR IRS1 EIF4E PMC9608867__F2 Immune regulation and emerging roles of noncoding RNAs in Mycobacterium tuberculosis infection STAT3 STAT1 BAG2 ROCK1 TRAF6 SOCS6 MYD88 PMC7279006__F1 Heme biosynthetic pathway, porphyrias and nutrients HMBS AIP ALAS1 ALAS2 FECH UROD UROS PMC6804961__F6 Structure establishment of three-dimensional (3D) cell culture printing model for bladder cancer CDH2 CDH11 MTOR PMC3137974__F1 Signal pathway activation by the main TLR and CLR receptors that detect Candida SYK TLR3 TLR4 MAL TLR9 IRF3 IRAK2 IRF7 TRAF6 IRAK4 CARD9 MYD88 PMC8670125__F7 Proteomic and biochemical responses to different concentrations of CO2 suggest the existence of multiple carbon metabolism strategies in Phaeodactylum tricornutum HPR MAL PDC OTC PMC4992436__F3 Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology NLRP12 BCL10 RELB TRAF3 TRAF6 CYLD TRAF2 PMC7895570__F1 Lipid metabolism of cancer ACLY LPL FAS PMC5118783__F3 Roles of Nanog in Cancer STAT3 SOX2 CTNNB1 PMC7382785__F4 Illustration of aptamer involvement in cancer immunotherapy CD40 CD80 APC PMC11806174__F3 Deciphering Regulatory Networks Governing Seedling Emergence in Deep-Sown Direct-Seeded Rice Cultivation ADAR CP ADA PMC8238218__F4 Up- and down-regulated DEGs in the adenosine 3’,5’-cyclic monophosphate (cAMP) signaling pathway (map04024) between female control versus female DXM treated (FcVSFt) VIP RRAD SELL SOX9 BRAF GIP NPY AMH PMC4284744__F1 Fibroblast Low-density lipoprotein (LDL)-related protein-1 (LRP-1) signaling in renal fibrogenesis BAD HEL-S-28 PMC12120097__F11 Exploration of the mechanism of Polyphyllin I against hepatocellular carcinoma based on network pharmacology, molecular docking and experimental validation VEGFC BAD FRK APC LRP5 LRP6 PMC6071520__F5 MiRnome circulating in plasma after injury is predicted to be controlled by miRNA processing enzymes and to affect different signalling pathways CDH2 DGCR8 CDK7 ITGA1 DICER1 CCND2 E2F2 SMAD2 MAP2K1 MAP2 DROSHA PMC2727126__F1 Noteworthy, the inhibition of this pathway through COX-inhibitors leads to induction of apoptosis and tumor growth reduction (Figure ) TES EGF LOX PMC8510467__F5 Systematic Review of the Biological Effects of Cordycepin PRR5 RHEB TSC2 RICTOR ULK1 MTOR DEPTOR PMC11640686__F6 Chemically induced reprogramming of RPE into neural stem cells and into neurons in the brain and retina [12,27,46,93] IGF1 DKK1 CIPC PMC9334758__F2 Eliciting pyroptosis to fuel cancer immunotherapy: mechanisms and strategies GSDMD GSDMC GZMA GSDMB DFNA5 PMC6105724__F6 Neuropathology following treatment with NP03-lithium STAT3 GFAP GSK3B LRP6 MTOR EIF2A CTNNB1 PMC3632644__F2 GLI1 Isoforms and cancer characteristics CD24 SHH VEGFA PMC11640686__F5 Chemically induced reprogramming of ESCs and iPSCs into neural stem cells and into neurons of the brain and retina [2,47,52,54,97,98,99] IGF1 CIPC PMC11640686__F2 Some small molecules and signaling pathways promoting the development of the nervous system (based on the poster https://www TGFBI SMAD2 SMAD4 SMO NODAL MTOR PMC11640686__F3 Chemically induced reprogramming of fibroblasts into neural stem cells and into neurons in the brain and retina [12,36,37,39,41,42,43,85,86] LPA GDNF IGF1 SHH CIPC BDNF PMC3294063__F1A Molecular Pathways: Beta-adrenergic signaling in cancer IFNG STAT3 SNAI2 BAD GATA1 RAP1A IL6 PTGS2 MMP9 SRC IL12B PMC4992436__F1 Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology RELA TRAF5 TNF TRAF2 IL1B PMC4992436__F2 Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology CXCL12 CXCL13 RELB TRAF3 TRAF2 PMC7541492__F2 Tumor microenvironment (TME) contributes to resistance via EMT EGFR CCR2 POLI MMP9 CCL2 PMC3642156__F1 Host immune response to viral infection (Interferon Signaling Pathways) SOCS1 STAT2 IRAK1 TLR7 TRAF6 TYK2 PMC4314327__F3 Macrophage immunoregulatory pathways in tuberculosis IL6 MB CD6 PMC9652895__F7 Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer STAT3 BAX BCL2 ATF4 IL6 IL6R PMC8651562__F1 Suppression of InterferonA Treatment Response by Host Negative Factors in Hepatitis B Virus Infection IFITM2 STAT2 EGFR IRF9 IRF3 IRF7 STAT1 IFNAR2 USP18 IFNAR1 ISG15 JAK1 TYK2 PMC4171984__F1 Insulin/IGF-1 signaling pathways TSC2 BAD RICTOR GRB10 TSC1 IGF1 PTEN GRB2 MTOR INS IGF2 IRS1 PMC4420735__F3 A model of telomerase RNP biogenesis NHP2 GAR1 NOP10 TERT PMC2943318__F7 Ulk3 function in Shh signaling pathway SUFU PTCH1 SHH SMO PMC3636752__F1 Distinct activation pathways for different CDKs CDC2 CDK7 WEE1 CDK2 MYT1 CDK4 PMC5531345__F7 Scheme of the pathway mediating the VEGF-induced disassembly of adherence junctions and its regulation by NDPK-B CTNNB1 PMC7948516__F1 Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing LPL TG GLCE SLC38A1 PMC5742161__F11 The illustration of CGA protecting against liver fibrosis in vitro and in vivo by regulating miR-21-regulated TGFB1/Smad7 signaling pathway CGA SMAD2 PMC6699068__F1 Notch signaling in bone tissue development SOST DKK1 NOTCH2 NOTCH3 NOTCH1 CTNNB1 PMC7339205__F7 PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/B‐catenin signalling pathway BAX APC PLK1 CTNNB1 PMC6923660__F8 The activation of leptin signaling pathway in preadipocytes induces adipogenesis and the production of proinflammatory cytokines LEPR MTOR PMC5378934__F8 Schematic model of TBL1XR1-promoting ERK activation and gastric cancer progression CDH2 MMP7 ZEB2 TBL1XR1 CTNNB1 PMC5993186__F1 Coproheme decarboxylases - Phylogenetic prediction versus biochemical experiments HMBS UROD UROS PMC6374012__F1 Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach SOCS1 STAT1 STAT2 JAK1 TYK2 PMC4043133__F9 Proposed site of PEP7 inhibition of the AT1R-Erk1/2 signaling cascade EGF EGFR PMC9109208__F5 It's about time; divergent circadian clocks in livers of mice and naked mole-rats PER3 KHK DBP PER2 PER1 NR1D1 CRY2 CRY1 NR1D2 GCK PMC7862069__F3 Inhibitors targeting Bruton’s tyrosine kinase in cancers: drug development advances SYK CD79B CD79A CD5 BLNK CD19 MYC MYD88 BTK BCL10 BCR LYN CXCR4 PMC6791698__F1 Metabolic pathways concerning dTTP biosynthesis GLDC DHFR NDP PMC6616624__F5 Main energy metabolism and carbon/nitrogen fluxes in heterocysts MAL CS CIT PMC9223434__F7 Application of Sensitivity Analysis to Discover Potential Molecular Drug Targets STAT1 STAT2 IFNAR2 IRF9 IFNAR1 IRF1 TAP1 PMC2040031__F1 INTERLINKING INTERLEUKIN-7 BAD JAK3 JAK1 PMC8122377__F3 Hepcidin Signaling in Health and Disease: Ironing Out the Details STAT3 SMAD1 DKFZp781O1323 SMAD4 MYD88 PMC4911360__F14 Gene-network of not isolated genes selected by Net-Cox in the GSE7390 breast dataset MSH2 BCL2 CCR4 IL9 FGFR2 PMC7422622__F1 Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms THBS1 HGF TFPI IGFBP7 PMC4911360__F11 Gene-network of not isolated genes selected by Adalnet in the TCGA ovarian dataset RB1 FZD3 APC DHX38 GMPR PMC2774752__F1 Puzzles, promises and a cure for ageing BAX PI3 BCL2 PTEN PMC4467383__F4 Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery BRDT BRD4 PAF1 BRD3 PMC7444709__F3 Physiological and pathophysiological functions mediated by TRPC4 in response to receptor-operated activation of Gq/11 and/or Gi/o proteins. A & B ITCH TRPC4 TRPC1 NACA OTP PMC4467383__F2 Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery BRD4 GATA1 BRD3 BRD2 PMC2808158__F7 Schematic summary of effect of IL-4 priming on phagocytic and secretory capacities of MΦs JAK3 JAK1 TRAF6 IRS1 PMC9630328__F1 Tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors STAT3 FOXP3 PMC10555535__F1 Metabolic pathway of exogenous and endogenous lipoproteins LPL APOE LDLR PMC9630328__F2 Tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors STAT3 CXCL12 CCL22 AXL MICA CCL5 TNF CCL2 CXCL8 IFNG TIGIT CD9 CCR4 MICB PMC9141761__F1 Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update GSK3B MTOR IRS1 PMC9141761__F2 Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update BACE1 APP IRS1 PMC3231999__F1 Immune evasion strategies of Porphyromonas gingivalis TLR1 GSK3B CXCR4 RAC1 PMC7689244__F9 iTRAQ-based proteomics reveals serum protein changes in hypertensive rats induced by a high-salt diet CRK BAD VASP RAF1 HEL-S-28 PTEN ARHA SHE CTNNB1 PMC5039409__F3 Cardiovascular Disease Chemogenomics Knowledgebase-guided Target Identification and Drug Synergy Mechanism Study of an Herbal Formula ACHE PPARG POLL EGFR GSK3B CHRNA7 TRPV1 AKR1B10 REN HMGCR COX2 ADRB2 ADRB1 PMC8008708__F2 Scheme depicting the biogenesis of different classes of EVs EGFR ARF6 RAB35 ARHA PMC5925008__F5 Summary of working thesis of the study NLRP3 IL16 IL1B PMC5761662__F8 Oncogenic KRAS regulates amino acid homeostasis and asparagine biosynthesis via ATF4 and alters sensitivity to L-asparaginase ATF3 NAAA ATF4 ASNS EIF2A TRIB3 KRAS PMC8634476__F2 Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients APC ROR2 LRP5 LRP6 RYK RHO CTNNB1 PMC8634476__F3 Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients ANGPTL4 GPR18 FABP5 DLL4 FABP4 VEGFA PMC1168814__F8 The regulation of replication-dependent histone H4 genes at the G1/S phase cell cycle transition via the cyclin E/CDK2/p220/HiNF-P pathway relative to the E2F/pRB pathway CDK6 DHFR CDK2 CDK4 PMC8634476__F1 Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients VEGFB TSC2 VEGFC BAD TSC1 SMAD2 DLL4 NRP1 PTEN MTOR VEGFA PMC2361340__F5 Differential targets of copy number-induced expression changes in key biochemical pathways between SCLC and NSCLC HMGB1 ID2 SOX11 E2F2 EGFR JUNB SMAD4 MAPK9 TCF4 KRAS DSCAM CDKN2A TIAM1 CDK2 KNTC1 NLK ING1 CDK4 PMC6023588__F4 Metabolic mechanisms of exercise-induced cardiac growth CITED4 MTOR CEBPB PMC6023588__F3 Schematic of glycolysis and ancillary glucose metabolism pathways FAS PC HEL-S-30 PMC10343257__F10 Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha NLRP3 MTOR PMC11676223__F1 Irisin: A Multifaceted Hormone Bridging Exercise and Disease Pathophysiology UCP2 NLRP3 ATF4 MTOR PMC7880431__F4 Anti-epileptic drug topiramate upregulates TGFB1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity PIGH TGFB1 SOX9 SMAD2 PTCH1 F7 UBE3B SHH TGFBR1 PMC9265893__F3 Ferroptosis and Its Role in Chronic Diseases STEAP3 GPX4 FACL4 MTOR ELOVL6 PMC5304257__F2 miRNAs control inflammatory response in ECs KLF2 CXCL1 CCL2 PMC9100407__F9 Proteomic Investigation of Molecular Mechanisms in Response to PEG-Induced Drought Stress in Soybean Roots SDHA DLAT PC HEL-S-32 CS HEL-S-26 PMC9701458__F4 Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Molecular Mechanism of Triptolide in the Treatment of Membranous Nephropathy APRT ZAP70 MMP16 PPARG STAT3 SYK RAF1 CCR5 HEL111 CCR2 PIK3R1 TAP1 HIF1A CCL5 MAPK8 FGFR2 ALB BCL2L1 MME F10 FGFR1 PRKCA WAS PTGS1 MMP2 MMP3 FLT1 KDR GRIN1 SRC CCR1 MAPK1 NR1i1 NOS2 CASP8 MIF ITGB3 HRAS GSTM1 CDK5 HMGCR ADRB2 HSPA4 CYP2C9 BCL2 ADAM10 ADRB1 LCN2 CDC42 PGR EGFR SPHK1 BRAF LYZ MTOR TGFBR1 GP1BA BTK REN INSR F2 TLR4 ROCK1 DPP4 CNR1 IL2 MITA HPRT1 SLC5A2 CYP1A2 ACHE HEL-S-72p ITGA4 ERBB4 SELE FOLH1 RBP4 MMP9 PTGS2 ARHA RAC1 ITGB1 RAB11A NFKB1 HEL-S-69p CASP3 CFTR MAP2K1 CYP3A4 PMC8187928__F1 Cellular cholesterol metabolism ABCG1 NPC1 HMGCR SQLE LDLR CH25H RHO FDFT1 ABCA1 MVK PMC7813762__F5 Representative metabolic pathway maps of differentially expressed proteins involved in TCA cycle (A) and proteasome (B) in KEGG RPN2 RPN1 ARC PMC6425834__F2 Models for potential interaction between Toll-like receptor 4 (TLR4) and protease-activated receptor 2 (PAR2).(A) Direct interaction at the plasma membrane model TBK1 TLR4 CD14 IRF3 TRAF3 TRAF6 MYD88 PMC10572466__F6 Schematic drawing illustrating the action mechanisms underlying the effects of baicalin on cytoskeleton rearrangement induced by PVL in BMECs ROCK2 LIMK2 LIMK1 ARHA PMC11676223__F3 Figure depicts the capacity of irisin to affect multiple pathways involved in age-associated neurodegeneration and mechanisms underlying AD pathogenesis FNDC5 NGF IGF1 BDNF SIRT1 PMC9610703__F5 Current Insights into miRNA and lncRNA Dysregulation in Diabetes: Signal Transduction, Clinical Trials and Biomarker Discovery BAX RAF1 FRS2 MAFG KEAP1 GSK3B FGF10 IRS1 IGF1 FOXO1 BCL2 GRB2 SIRT1 PMC3071979__F2 Inhibition of NFKB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice ZAP70 EGF LTA TIRAP INA CD46 MYD88 HDAC1 UBE2V1 MAP3K7IP1 PLCG2 RELA BMP4 BMP2 SI APP LPP HDAC2 TRAF2 LCK PMC8840292__F6 Microplastics (Polystyrene) Exposure Induces Metabolic Changes in the Liver of Rare Minnow (Gobiocypris rarus) DEK CERK ALK ABCD2 ABCB11 CHIT1 MAL ABCD3 ddo TIGAR PSAP ABCB9 PMC98985__F3 Overview of metabolic pathways for glucose and xylose metabolism tal-1 XK XDH PMC6677770__F7 Scheme of SAMHD1’s role in HMA metabolism and effector functions CDA DCTD PMC8918542__F1 Clinical Importance of Potential Genetic Determinants Affecting Propofol Pharmacokinetics and Pharmacodynamics CYP2B6 UGT1A9 SULT1A1 CYP2C9 PMC7728170__F2 Interleukin-17A pathway target genes are upregulated in Equus caballus supporting limb laminitis COX2 S100A8 MMP9 S100A9 CCL20 PMC2773646__F1 Nodal signaling pathway FOXH1 SMAD2 SMAD4 NODAL PMC4739231__F1 Signaling pathways demonstrating the link between Gq-coupled receptors and induction of autoimmunity STAT3 TSC2 RAF1 PTEN MTOR PMC9359488__F2 Host genetic diversity and genetic variations of SARS-CoV-2 in COVID-19 pathogenesis and the effectiveness of vaccination C6 DBP STAT2 IRF9 HLA-DRB1 CCR2 CXCL16 IRF3 IRF7 MYD88 IFNG TLR3 TLR4 IFITM3 C9 TLR7 TYK2 PMC9265893__F1 Ferroptosis and Its Role in Chronic Diseases TF SLC3A2 STEAP3 GPX4 TPD52 DPP4 FACL4 ALOX15 SLC7A11 ATF4 ADA PMC3614511__F8 Transcriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis Via TGFB–TAK1–Dependent Mechanism MMP10 HDAC7 MEF2C PMC4516533__F5 Proposed model for EGFR-related signal transduction pathways regulating Snail in Ishikawa (A), Ishikawa ER- (B) and primary human endometrial tumours (C) EGF PAK1 EGFR GSK3B PMC3818893__F6 Hypothetical role of the AhR pathway in the development of inflammatory bowel disease after exposure to environmental PAH AHR PAH IL1B PMC6199630__F12 MAPK and PI3K signaling pathways CDC42 ERBB3 GSK3B ERBB2 PTEN IGF1R RHO MTOR SRC MEF2C IRS1 PMC2857176__F3 Map of selected p53 pathway-associated genes that harbor known or potential functional SNPs (octagon-shaped boxes) and their closely interacting genes (rectangular boxes) TP73 MDM4 FAS CDK2 ATM MDM2 MYC CDK4 PMC6733437__F1 Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway BAX MEI1 BOK PMC2147077__F4 A High Quality Draft Consensus Sequence of the Genome of a Heterozygous Grapevine Variety TES IPP FH IDI1 PMC7606590__F1 Intracellular model of GH signaling under normal and pathological conditions in Human adipocytes: LPL G0S2 SRC PMC8073060__F2 Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction CA12 SMAD2 AKAP6 PDE4D HIF1A AKAP12 AKAP10 PMC11562642__F5 Schematic diagram illustrating the toxicity mechanism of MNNG in the gastric mucosa and the protection mechanism of FA against MNNG-induced gastric mucosal injury NLRP3 PTEN MTOR PMC3944655__F1 Molecular mechanisms linking ROS, antioxidants, and the insulin signalling pathway SIRT3 PTEN IRS1 PMC9891206__F2 Targeting STING: From antiviral immunity to treat osteoporosis TBK1 CGAS IRF3 PMC6199630__F15 Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis HEL-S-92n FEN1 H2AX EGFR ATM PMC8560265__F5 Increased Death of Peripheral Blood Mononuclear Cells after TLR4 Inhibition in Sepsis Is Not via TNF/TNF Receptor-Mediated Apoptotic Pathway BAX TLR4 BCL2 TNF PMC3072659__F1 Pathways that modulate canonical Wnt signaling BCL9 EGF HGF APC LRP5 LRP6 GRB2 CTNNB1 PMC5342722__F7 Sulfatase-1downregulates mesothelin and leads to reduction in lymphatic metastasis STAT3 BAX BAD MSLN CDK2 WNT1 PMC4089392__F1 Toward the development of podocyte-specific drugs FYN SYNPO TLR4 VTN TRPC6 PMC6620681__F1 De novo and salvage pathways for NAD+ biosynthesis NNMT NAPRT HEL-S-90n NAMPT PMC6200785__F8 Indian hedgehog homolog signaling pathway SOX17 KLF4 PTCH2 PGR PTCH1 BMP2 IHH MCM6 WNT4 MCM2 HAND2 PMC8111986__F5A Identification of an immune classification for cervical cancer and integrative analysis of multiomics data CYP24A1 MAK TPM3 HEL2 PMC3193487__F1 Schematic of crosstalk between TLR pathway and MHC molecules CD40 BTK TLR3 TLR4 IRF3 MYD88 PMC6119347__F2 Network created by Ingenuity Pathway Analysis using the top 36 most highly connected genes disrupted by rolandic epilepsy (RE) CNVs as assessed by the Disease Association Protein-Protein Link Evaluator DLG2 DACT2 TJP1 NRG3 N4BP2 NRG4 SIRT3 ADAM20 STAT1 INSRR ADAM22 NOMO3 DQX1 DCN KLHL17 ADGRA1 ZNF385A KIRREL3 HAPLN3 JUN ERBB4 ADAMTS9 ENTPD2 IRAK1BP1 ACACB IKBKB ABCC6 PMC9208181__F1 Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases CDC42 RHO MTOR PMC3255978__F7 Proposed mechanisms underlying the regulatory control of fibrosis development by the PAI-1/uPA balance in aged-associated muscle dystrophy progression SMAD2 PLG PTEN PMC11653397__F5 Proposed metabolic pathway of PCB95 in mice exposed to PCB95 based on the LC–HRMS analysis of intestinal content samples OGT DHDH PMC7066079__F7 Proposed model to illustrate the role of FAM83A in the Wnt and Hippo signaling pathways FAM83A APC GSK3B CCND1 CTNNB1 PMC6895193__F6 As a tumor-suppressor gene, RASSF1A mainly acts as a crossroad of three intertwined molecular signaling mechanisms including Ras/Rho GTPases, MTs, and Hippo pathway MOAP1 MAP1S MAP1B RHO MTOR HDAC6 PMC8980946__F1 JAK‐STAT core cancer pathway: An integrative cancer interactome analysis STAT3 EGF BCOR FAS HGF OSM STAT2 TET1 LIF BRCA2 PTEN MTOR CNTF STAT1 TSLP CDK6 STAT5B BRCA1 NCOR1 PRC1 STAT4 GRB2 GAB2 PMC3558831__F6 PIAs recapitulate the activity of two tumor suppressors that converge on mTOR TSC2 PTEN MTOR PMC1856802__F5 Canonical Wnt signalling pathway and its APC partner in colon cancer development BCL9 FYN FER CTNNB1 PMC5198184__F1 Metabolic stress-mediated induction of an inflammatory response via ER stress signaling pathways GSK3B EIF2A CCL2 XBP1 IL1B PMC1856802__F2 Canonical Wnt signalling pathway and its APC partner in colon cancer development APC GSK3B CTNNB1 PMC3062534__F1 Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort FH HEL-S-62p CFI CFH PMC8712397__F5 Tools, Tactics, and Objectives to Interrogate Cellular Roles of O-GlcNAc in Disease OGT TRIM28 PMC8712397__F1 Tools, Tactics, and Objectives to Interrogate Cellular Roles of O-GlcNAc in Disease OGA OGT IMPACT PMC9369364__F3 TM4SF5-Mediated Regulation of Hepatocyte Transporters during Metabolic Liver Diseases SOCS1 TM4SF5 AFP SOCS3 CCL5 CCL2 SIRT1 CD34 PMC10705753__F1 Illustration of semaphorin 6A–D signaling pathways and their interaction with the cellular molecular network in cancer cells STAT3 SNAI2 ECD SEMA6B TCF4 ARHA CTNNB1 NR1C1 SEMA6D FGFR1 ZEB2 SRC GNG11 CCND1 HES1 NOTCH1 PMC7880431__F1 Anti-epileptic drug topiramate upregulates TGFB1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity MYO1D GDF8 PBX1 GSK3B WNT9B FGFR2 EPHB2 UBA2 DLX1 SNAI1 ITGB8 FOXC2 GDF11 FGFR1 SHH UBB HEL-S-44 CYP51A1 SNAI2 ACVR2A TCOF1 MNT TBX1 PLG LRP6 COL2A1 GBX2 CRK EFNB1 EPHB3 HEL23 EDN1 TP63 MAP3K7 CDKN1C GSC DHCR7 CYP7B1 RET DPH1 HSPG2 TGFB1 TRADD EGFR OSR2 DHFR F7 GAD1 RYK VAX2 TGFBR2 MDM4 SUMO1 TYRO3 MSX1 BMP4 CHEK2 AHR CHUK JAG2 TNNI3 GAS1 DNMT3B WFIKKN2 ALX4 PHC1 NABP2 PITX2 BARX1 ADH7 IRF6 GLCE PDGFRA SKP1 PMC10705753__F3 Illustration of the mTOR–Sema6D–PPARG signaling pathway in controlling macrophage polarization toward anti-inflammatory (antitumorigenic) phenotype M2 via regulation of fatty acid uptake and metabolic reprogramming PPARG SEMA6D CD36 FABP4 ARG1 TNF PMC5496883__F3 Signalling by Rho GTPases (upper panel) and Neuronal system pathway (bottom panel) CDC42 KCNQ5 AGER KCNJ6 ABCC9 PMC9688694__F1 Antitumor Activities of Interleukin-12 in Melanoma STAT3 STAT1 IRF1 IL2RA STAT4 IRF4 IL12RB1 PMC7288986__F1 HDR-mediated genome editing IL2RG NCF1 CYBB PMC5338640__F3 Modeling, Signaling and Integrated Modeling-experimental Frameworks in Cell Migration CDC42 ARHA SRC PMC12209467__F3 HIF signaling pathway and targeted therapy in PH STAT3 BAX SNAI2 BAD PCNA HEL-S-133P RASSF1 HK2 IL33 NAMPT NCOA6 AREG VEGFA CCL2 PECAM1 PHB2 SNAI1 E2F3 KLF5 RRP1B CXCR4 TWIST1 ARG2 PMC6333681__F1 Environmental pollutant-induced obesity and metabolic diseases: involvement of BAT impairment DDT PPARG PRDM16 PMC5338640__F4 Modeling, Signaling and Integrated Modeling-experimental Frameworks in Cell Migration WNT3A APC GPT PMC8170118__F3 Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data HEL114 ACTN4 ZYX BCL2 APP TLN1 CCND1 FOS PMC12209467__F4 MAPK and PI3K/Akt signaling pathways in PH BMPR2 BAX SMAD1 EGR1 DKFZp781O1323 PCNA SPHK1 PTEN MTOR FGF2 BMP4 PAH METTL3 PMC8170118__F5 Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data RAF1 RASSF1 LAT PLA2G4B PMC12209467__F2 BMPR2 and TGFB signaling pathways in PH BMPR2 STAT3 HEL-S-101 COMP SIN3A PCNA GSAP HEL-S-28 DFNA5 TNF ID1 INHBA HMGA1 PFKP FHIT NBL1 NOTCH1 PMC4486076__F1 Autophagy in Autoimmune Disease ATG101 ATG10 ATG3 ATG12 ULK1 VMP1 AMBRA1 MTOR ATG5 ULK2 PMC12209467__F7 Wnt signaling pathway and targeted therapy in PH CDC42 BAX PCNA ROR2 FZD7 LRP5 LRP6 TCF4 EGR2 TWIST1 CTNNB1 PMC12209467__F8 BMPR2 and TGFB crosstalk with other signaling pathways in PH BMPR2 HMGB1 SMAD1 FZD2 SMAD2 FZD7 NOTCH2 TNF CXCL8 CTNNB1 BMP6 STAT1 FZD8 TLR4 NOTCH3 SRC PMC12209467__F5 NFKB and NLRP3 signaling pathways in PH CASR NLRP3 HDAC10 NLRC3 KIF23 PMC12209467__F6 Notch and AMPK signaling pathways in PH BMPR2 DLL4 MTOR NOTCH2 TUG1 TNF SKP2 NOX4 FOXM1 FOXC1 PAH NOTCH3 SRC SIRT1 HES1 NOTCH1 PMC9812393__F8 SKN-1A/Nrf1 lipid homeostasis response FITM2 PLIN1 PC PMC12209467__F9 PI3K, NFKB and AMPK crosstalk with other signaling pathways in PH NLRP3 DLL4 NLRC3 PAH TRAF6 FGF2 PMC11759460__F7 Graphical abstract LAMP2 TFEB POLE PMC5286959__F1 SCFFBW7 ubiquitin ligase targets SOX9 for proteasomal destruction SOX9 EGFR MTOR KRAS PMC6566201__F6 Fighting Thyroid Cancer with Microgravity Research IL15 EGF PFN1 PXN ARF6 FGF6B CPNE1 IL17A VEGFA IL6 CCL2 CXCL8 SPP1 HEL114 CTCF RELA PRKCA MMP2 EN1 VCAM1 LCN2 PMC8996529__F6 Jasmonates and Histone deacetylase 6 activate Arabidopsis genome-wide histone acetylation and methylation during the early acute stress response TH CRAT CAD PMC8422639__F11 Synergy of nanodiamond–doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells BMS1 HMGB1 PMC9063253__F4 V-ATPase in cell death and cancer STAT3 BAX SLC40A1 CASP8 GPX4 TMBIM6 MTOR BCL2L11 TFEB CASP3 TNFSF10 CA9 BAK1 PMC5539153__F8 Representative model of some signaling pathways in a human breast cancer cell (MDA-MB-231) that can be modulated by GCdcPLI BAX BCL2L1 BAD COX2 BCL2 MDM2 MTOR PMC9620650__F2 Role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights ATG101 ULK1 CER1 BNIP3 ATF4 MTOR CXCR4 ATG5 SIRT1 PMC128926__F2 Activation of the NFKB pathway by IL-1 IL1R1 IRAK2 TRAF6 MYD88 PMC6789187__F2 Citrate produced through mitochondrial metabolism can enter the fatty acid synthesis pathway ACLY LPA FAS COX1 HMGCR COX2 C2 SCD PMC3398118__F1 Diagram of the pentose phosphate pathway showing substrates and enzymes involved in it HEL107 RPE RPIA RBKS PMC5538844__F10 Cell mechanisms by which MPLA prevents inhibition of absorption by LPS in the MTAL TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC6521490__F3 By KEGG pathway enrichment analysis, ANXA2 upregulated filopodia pathway, resulting in cell metastasis HEL114 CRK ATR VASP FYN PXN RHO SHE INS PMC3713495__F4 EZH2 promotes E2F driven SCLC tumorigenesis through modulation of apoptosis and cell cycle regulation RB1 BAD PCNA E2F2 E2F3 DHFR EZH2 PMC7767241__F1 Diagram highlighting prominent pre- and post-transcriptional interactions between NFKB and the Lin28/let-7 pathways STAT3 LIN28B LIN28A RELA RELB IL6 MYC PMC7786975__F1 Metabolic characteristics of M1/M [LPS(±IFNG)] macrophages ACLY ASL ACO2 F2 HIF1A RET PMC7786975__F2 Metabolic characteristics of M2/M [IL-4/IL-10] macrophages PFKFB1 GLS CD36 F2 ARG1 PMC7601745__F4A Indoxyl Sulfate-Mediated Metabolic Alteration of Transcriptome Signatures in Monocytes of Patients with End-Stage Renal Disease (ESRD) PSMB6 GPC4 VASP HEL-S-62p F5 WSB2 ABHD5 LPCAT3 HSD3B7 MCEMP1 TNF CXCL8 ITGAV VSIG4 POR ADAM17 FAM20C TRIM25 c-fgr FBP1 XYLT1 CCR1 HEL-75 SOCS6 PMC3777336__F4 Differentially expressed genes (DEGs) related to the cell cycle STAG2 DBF4 ATR CDC20 E2F2 STAG1 ORC6 SMAD2 SMC3 APC SMAD4 ORC3 SKP2 ORC2 CDK7 E2F4 E2F3 CDK2 ATM MDM2 SCT CDC25B PMC7862680__F7 Novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway VASP PRTG PMC7330686__F3 Aromatic hydrocarbon in conjunction with CYP1B1 signalling pathway AHR PAH CYP1B1 PMC8717598__F1 Toxoplasma gondii apicoplast-resident ferredoxin is an essential electron transfer protein for the MEP isoprenoid-biosynthetic pathway IPP FAS FES PMC4436905__F1 Adipocyte secreted leptin and interleukin-6 has a paracrine effect on nearby breast cancer cells STAT3 SOX2 PMC12016271__F10 SFI on podocyte INSR and eNOS proteins in the IR signaling pathway INSR IRS1 PMC7695578__F7 Schematic model showing the hypothesis for COVID-19 infection STAT1 STAT2 JAK1 ACE2 TYK2 PMC4601492__F5 Coronin-1C-mediated Rac1 trafficking RCC2 RAC1 CORO1C PMC6181017__F9 Suggested Schemes for PGI1-Mediated Biosynthesis of MEP Pathway Isoprenoid-Derived CKs and GAs in Cells of Vascular Tissues, and FAs and Proteins in Mixotrophic Maturing Embryos of Arabidopsis IPP HEL-S-162eP GPT PMC4462002__F7 Fanconi Anemia Pathway BCCIP ATR LIG1 ID2 USP1 SLX4 PMC9277157__F8 Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-29a Improves Ovarian Function of Mice with Primary Ovarian Insufficiency by Targeting HMG-Box Transcription Factor/Wnt/Beta-Catenin Signaling APC CTNNB1 PMC11768371__F7 Mechanism underlying the gedunin-mediated inhibition of C NLRP3 MYD88 PMC8943601__F1 Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases BAD MTOR IRS1 PMC3021862__F4 Genes regulated by Survivin in ITD-Flt3+KSL cells and deregulated in LSC are mapped on functional signaling network associated with epidermal growth factor receptor signaling pathway IL15 CDC42 VWF ETS2 RAF1 EGFR SPIRE1 CREM ARHA MAPK14 GNRHR c-fgr GRB2 SRC PMC4955670__F4 Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer AURKA IGFBP1 PRKCZ TCF4 CDKN2B MYC MAPK3 TGFBR2 BCL2L1 AFP MDM2 ARHGEF2 CCND1 CCND3 BAX JUN E2F2 PTPN11 BCL2L11 GPC3 TFF3 RAC1 FOS BRCA1 NFKB1 BCL2 TSPAN8 RRAS LCN2 PMC4955670__F5 Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer MAFK JUN ETS2 SERINC3 WNT3A JUNB NGFR RELB PTEN MYC GPC3 FOS TOR2A CTNNB1 BEX1 BMI1 LAMP2 FOSL2 AFP WWOX APP GAS1 PMC3554623__F2 Battle between Rotavirus and Its Host for Control of the Interferon Signaling Pathway TBK1 TLR3 IRF3 IRF7 EIF2A EIF4E PMC4955670__F6 Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer AURKA EGR1 TGFA ROCK2 CDC6 IGFBP1 PTPN11 TGIF1 CDKN2B CCNA2 PLK1 TFF3 MAD2L1 CTNNB1 MAPK3 TGFBR2 CDK6 NFKB1 TSPAN8 MCM6 MDM2 CCNB1 CCND1 CDK4 PMC7859922__F1 Chemokines in hepatocellular carcinoma CXCL12 CXCR4 PMC4031539__F5 Summary figure of the switch from Pu.1 interaction with coactivators to corepressors caused by Runx1 deficiency PRMT1 BMI1 HDAC3 SMARCE1 TRIM28 RBBP4 CARM1 MRGBP PBRM1 HDAC2 SMARCA4 ZNF326 SMARCC1 REST SIN3A TLE4 SATB1 CHD4 SMARCA1 HAT1 SAP18 RUVBL1 SUV39H1 SIRT1 CBX1 TLE2 RBBP7 HEL25 SMARCC2 PRC1 EPC1 GPS2 TLE3 LBR PARP1 CHD3 PHB2 NCOA5 HDAC1 BAZ1A SAP30 KDM1A SMARCD2 RUNX1 DMAP1 ACTL6A RUVBL2 SMARCD3 MBD3 MBD2 PMC5423041__F1 Molecular mechanisms involved in macrophage inflammatory protein-2 secretion of macrophages STAT3 TLR4 SOCS3 PMC10534417__F1 Putative biosynthesis pathway of limonin IPP HMGCR MVD MVK PMC3117645__F9 The miR-29 regulatory network in Zmpste24−/− progeroid mice CDC42 PPM1D IFI30 DUSP2 NARF PMC3993568__F10 PI3K/Akt1 pathway is a downstream effector of Jak2/Stat5 signaling in luminal mammary epithelial cells PRLR PRL PTEN SRC PMC506992__F7 MUC20 suppression HGF MUC20 GRB2 PMC8708687__F2 Targeting Mitochondrial OXPHOS and Their Regulatory Signals in Prostate Cancers TFAM NR2A1 AKT3 MTOR MYC TEAD4 PMC9077852__F9 Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/Beta-catenin pathway FOXM1 WDR5 CTNNB1 KIF23 PMC3116035__F3 A) Schematic outline of mitochondrial and metabolic pathways connected to the PPP in hepatocytes FAS AFP LPO TCF4 MTOR CTNNB1 PMC3199966__F1 Schematic biosynthetic pathways for the major phospholipid (Kennedy Pathway) and sphingolipid classes biosynthesized in mammalian cells and observed in MALDI IMS of mammalian tissues PGP HMFN0839 SMS tmp_locus_29 PEMT PC PMC6680887__F3 Dinoflagellate orthologues predicted in the base excision repair pathway OGG1 LIG1 MPG UNG MBD4 TDG PMC7575756__F8 Molecular mechanism underlying the tumor-suppressive effect of miR-766-3p in OS BCL9L APC GSK3B AXIN1 LRP5 LRP6 CTNNB1 PMC3760013__F5 Core genes for cetuximab and PX‐866 susceptibility EGFR MTOR MYC CCND1 RBPJ PMC6680887__F4 Diagrammatic summary of the dinoflagellate orthologues predicted in the nucleotide excision repair pathway ERCC1 XPA DDB2 CETN2 PCNA POLK POLE XPC PMC7338796__F2 Crosstalk between the tetrahydrobiopterin (BH4) and kynurenine (KYN) pathways SPR HEL-S-90n KYNU DHFR KMO PMC9617731__F9 Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling TLR8 TLR5 IRF7 PMC6680887__F5 Dinoflagellate orthologues predicted in the DNA mismatch repair pathway PMS1 LIG1 MSH2 MSH3 PCNA PMC2952389__F1 Outline of T-cell development pathway from bone marrow to the thymus TF CD44 CD48 ATL1 RUNX3 PMC3390208__F8 Signaling pathway involving CaMKK regulation of GluA1 synthesis and synaptic incorporation as CP-AMPARs MTOR BDNF PMC6518732__F1 STAT3 signaling pathway in cancer cells STAT3 EGF EGFR PTPRT SRC PMC8430839__F2 Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus STAT2 IFNAR2 IRF9 JAK1 TYK2 PMC7751845__F8 Crosstalk between HepG2 cells and TAMs-like macrophages HMGA2 PMC4049898__F2 Wnt and planar cell polarity signaling in cystic renal disease FAT4 APC GSK3B PTK7 ARHA RAC1 CTNNB1 PMC2883790__F2 IGF-I activation of a signaling pathway to mTOR RHEB TSC2 TSC1 PI3 PTEN RHO MTOR RAC1 EIF4E PMC6152528__F11 Hypothetical model for the signaling pathway and the role of FKB-induced autophagy in GBM cells RPS6KB1 DDIT3 ATF4 MTOR TRIB3 ATG5 PMC6273124__F1 PI3K-Akt-mTOR pathway TSC2 TSC1 PTEN PMC4373479__F1 TLR4 signalling TIRAP TLR4 IRF3 TRAF3 TRAF6 IRAK4 MYD88 PMC6510893__F5 The Conserved Response of chickens to NDV infection SOCS1 STAT1 IRF1 MX1 IRF7 PMC8698417__F4 Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation KEAP1 MAF ME1 PMC8698417__F1 Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation RBX1 KEAP1 GSK3B PMC11053566__F10 Proposed mechanisms of action of eudesmane-type sesquiterpene lactones on the TNF-Alpha-induced NFKB signaling pathway TRADD RELA RIPK1 TRAF2 PMC7405862__F1 Mechanisms involved in organ damages associated with COVID-19 ACE2 IL1B PMC10518439__F2 Pyroptosis and inflammasomes in cancer and inflammation HMGB1 GSDMD GSDMC GZMA GSDMB DFNA5 PMC5201094__F7 Hypothetic model illustrating the pivotal role of CD37 status for R-CHOP outcome in DLBCL and the important molecular mechanisms for R-CHOP resistance in CD37−DLBCL and CD37+ABC-DLBCL STAT3 ICOS ICOSLG BTK BCR CD37 POLI IRF4 MYC CXCR4 IMPACT PMC6854988__F11 The GO interaction network of coexpression genes (the cnetplot of coexpression genes from BP enriched pathway) NR1C1 RXRA AHR RXRG ABCC2 PMC6854988__F12 The GO interaction network of coexpression genes (the cnetplot of coexpression genes from MF enriched pathway) NR1C1 RXRA AHR RXRG PMC4229533__F1 Pancreatic cancer cell survival pathways in 5-fluorouracil resistance CDC42 STAT3 BAX EGF BAD APC GSK3B PTEN GRB2 MTOR SRC CTNNB1 PMC6530474__F10 Diagrammatic representation of constitutively activated TGF-Beta-signaling-mediated tissue fibrosis TGFBR2 ACTA2 SNAI2 TWIST1 TGFBR1 PMC4782570__F7 Proposed regulatory mechanism of insulin expression by the Wnt/Beta-catenin/NeuroD1 pathway in the hypothalamus NEUROD1 WNT3A CTNNB1 PMC6995390__F2 Signal transduction pathways in PSCs activation RECK FGF21 SMAD2 SHH IHH RHO PMC8579446__F3 Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer TF SLC3A2 LOX STEAP3 GPX4 LPCAT3 FACL4 SLC7A11 PMC3073278__F1 Tumor-induced DSB formation in vivo H2AX CCL2 SSB PMC7851696__F1 Critical Role of MetR/MetB/MetC/MetX in Cysteine and Methionine Metabolism, Fungal Development, and Virulence of Alternaria alternata CBL BHMT2 GPX3 PMC4959648__F1 Mitochondrial Oxidative Phosphorylation System (OXPHOS) Deficits in Schizophrenia ND1 ND5 NDUFV2 ND4 NDUFS1 PMC9539685__F1 Research progress on the relationship between the TOR signaling pathway regulator, epigenetics, and tumor development CDC2 CASP9 TIPRL CASP3 MYC STRN EIF4E STRN3 PMC9539685__F2 Research progress on the relationship between the TOR signaling pathway regulator, epigenetics, and tumor development RHEB TIPRL PTEN PMC10539319__F1 Systemic iron sources and metabolism IBRDC1 HEPH EPO PMC10539319__F3 Testicular iron metabolism and ferroptosis TF IBRDC1 SLC39A14 FTL GPX4 NQO1 LPCAT3 FACL4 SLC7A11 CP PMC2732416__F5 Roles of the ILS pathway and HSF1 in aggregation toxicity and longevity IGF1 PI3 HSF1 PTEN PMC8000993__F7 Simplified schematic of crosstalk between JA and ABA signaling pathways ICE1 SNRK ABI3 PMC4905215__F1 Endothelial-specific loss of GRK2 impairs maturation and vascular remodeling in adult and developmental angiogenesis ADRBK1 SMAD1 TGFB1 DKFZp781O1323 SMAD4 PMC7844244__F8 CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis FOXP3 PMC2862795__F1 Multi-component nature of TGFB and Wnt Pathways GSK3B SMAD4 CTNNB1 PMC5498621__F6 Examples of subnetworks in network reconstructed from injured swine brain treated with VPA TF GRIN2B MYO16 BCL2A1 NR1D1 INA NR1C2 NEFL SOX10 CCL2 XBP1 IAPP MGAT5B MEF2C CDK5R1 PROX1 SCG5 ASCL1 SYP NFKBIE AGXT2 VIP THBS1 NEUROD1 SNCA KIT DAAM2 PRRX1 NEF3 MAST1 RELN NEFH MEF2D VCAN TBR1 FGF7 MYT1L PHYHIP CASP3 BMP2 OPALIN KLHL4 ST18 CXCR4 NR6A1 SIRT1 NAT8L PMC6733901__F2 Pyroptosis in cancer: pro-cancer or pro-“host”? NLRC4 NLRP1 NAIP GSDMD NLRP3 AIM2 DFNA5 IL1B FADD PMC6353984__F5 Downregulation of G2/mitotic-specific cyclinB1 triggers autophagy via AMPK-ULK1-dependent signal pathway in nasopharyngeal carcinoma cells ULK1 ATG14 CCNB1 PMC7197765__F1 Cross-coupling reactions of benzylic C–H bonds and alcohols via a radical relay pathway ARX PMC9120423__F1 Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review PMC7393494__F7 Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs ATR FEN1 YY1 PMC11847233__F1 Regulatory effect of lncRNA Erdr1 on T cells BAX CCR6 CCL20 PMC3343703__F1 Heme metabolism CPO MB FECH UROD UROS PMC7564904__F1 In vitro Bacillus Calmette-Guérin (BCG) training NOD2 MTOR TNF IL1B PMC8364703__F5 Bacterioferritin: a key iron storage modulator that affects strain growth and butenyl-spinosyn biosynthesis in Saccharopolyspora pogona ACOX1 SDHB RPIA FADD PMC7163250__F9 Our hypothetical model integrating AMP-activated protein kinase (AMPK), Hippo, and TBK1 signaling pathways during normal (A) and ZIKV-infected states (B) LATS1 TBK1 LATS2 CGAS MAVS IRF3 PMC3732459__F3 Innate Immune Responses in Hepatitis C Virus Infection PRMT1 IFNAR2 USP18 IFNAR1 SOCS3 JAK1 TYK2 PMC6433789__F3 P53-HSF1-PGC1A integrated responses in HD SSBP1 FBXW7 HSF1 TAF4 MDM2 HTT DHRS2 PMC4225745__F1 Interaction between human GD T cell and tumor cell IFNG TH IPP CXCL13 MICA MICB CXCL10 PMC6868871__F6 Summary diagram demonstrating the contribution of IGF-1/IGFBP to transcriptional levels of PPARG, VEGF, and HIF-1A under the administration of BV intervention IGF1 IGFBP1 PMC3732459__F2 Innate Immune Responses in Hepatitis C Virus Infection TBK1 MAVS TANK IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TRIM25 TLR3 TLR8 TLR7 PMC3234494__F3 Cytosolic RNA sensors NOD2 IRF3 IRF7 PMC8868556__F5 Melatonin as a Smart Protector of Pregnancy in Dairy Cows BAX MTBP LIF BBC3 MDM2 PMC4911365__F3 Tumor-supportive effects of BMAT IL15 STAT3 IGF1 IL6 PMC5454774__F1 Scar-mediated inhibition and CSPG receptors in the CNS STAT3 PTEN ARHA MTOR PMC8024996__F1 Struggle of a good friend getting old: cellular senescence in viral responses and therapy FOXA1 SIRT3 CGAS IRF3 TREX1 DNASE2 PMC4417442__F2 HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy TRIM50 APOBEC3G CGAS NLRP3 H2AX TLR8 MX2 IFI16 TLR7 CPSF6 TREX1 PMC10981756__F7 Mechanism of the antineoplastic role of PQR309 and gemcitabine in nasopharyngeal carcinoma CDH2 STAT3 CTNNB1 PMC9477421__F5 Schematic diagram summarising the inferred functions of cofilin 1 (CFL1) and fatty acid binding protein 5 (FABP5) that interact with a prokaryotically-expressed (non-glycosylated) recombinant form of the Toxocara canis mucin 1 protein (rTc-MUC-1) NEDD8 ACTG1 UBC LCP1 PFN1 FABP5 ME1 CORO1A CAP1 YWHAZ PMC2631405__F1 Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models IGF1 FOXO1 PTEN PMC5147738__F5 Portion of the miRNA-augmented Regulation of lipolysis in adipocytes pathway PIK3CA PDE3B PIK3R5 INSR AKT3 ABHD5 LIPE FABP4 PNPLA2 MGLL INS PMC2912609__F2 Currently available therapies targeting EGFR signaling pathway EGF EGFR BRAF PTEN MTOR PMC5047222__F1 Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression OGA OGT FOXM1 RS1 HEL-S-28 CD19 MDM2 JAK1 GAB2 IRS1 PMC5295433__F8 G-protein-coupled receptors mediate omega-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway LATS1 TF NAIP MCL1 AREG BIRC2 PMC3574586__F2 Schematic representation of the sessile and traditional serrated pathways BRAF IGFBP7 KRAS MGMT PMC6637598__F2 Wnt/Beta-catenin signal transduction pathway BCL9 APC LRP5 LRP6 CTNNB1 PMC8089042__F8 Model and Summary: RGS10 regulates pro-inflammatory gene expression through functional interaction with the SOCE machinery TG STIM2 STIM1 UNG PMC8961181__F1 Genetics, Breeding and Genetic Engineering to Improve Cottonseed Oil and Protein: A Review LPA FAS PC LPP PMC8526999__F3 Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells CDC2 CDK6 APC CDK2 CYC1 USP37 CDK4 PMC5449515__F2 Mechanisms governing TGFB1–induced HASM contraction SMAD2 SMAD4 PMC2726710__F2 Intracellular signaling consequences of calpain-mediated substrate cleavage TH BAX BAD CDK5 SP4 MBP SP3 CTNNB1 MEF2D PMC11850813__F7 Molecular mechanism underlying knee arthrofibrosis TNC EGFR DPP4 CTGF PMC11186353__F3 Illustration representing the sites of action of different polyphenols in asthma pathway IL25 TSLP IL33 PMC11186353__F4 Illustration representing the sites of action of different polyphenols in cancer pathway RAD51 PLG PMC3735707__F6 Maternal factors required for oocyte developmental competence in mice GPD2 GPAT2 PMC4641965__F1 Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity UCP2 NR1C1 ADIPOR1 ADIPOR2 PMC9523578__F3 Bacterial effectors mimicking ubiquitin-proteasome pathway tweak plant immunity CERK SKP1 BAK1 PMC8972237__F7 Phenotypical, functional and transcriptomic comparison of two modified methods of hepatocyte differentiation from human induced pluripotent stem cells SIAH1 CES1 APC RYK ARC POR BAMBI SOST INVS RHOD NOTUM SKP1 NLK PMC11898993__F8 Molecular mechanism of GNC against IR-induced DOR TF POR TH HEL-S-130P NR3A2 KRT19 PMC9179265__F1 EPA Modulates KLK Genes via miR-378: A Potential Therapy in Prostate Cancer KLK14 KLK4 KLK6 AKT3 MAP2K1 GRB2 MTOR PMC7767317__F3 Modulation of the Nrf2-vitagene pathway by H2S RBX1 NLRP3 KEAP1 MAF SIRT1 PMC6715524__F4 Summary of histone PTM-mediated 53BP1 and BRCA1 DSB repair pathway choice regulation BARD1 HDAC1 L3MBTL1 BRCA1 RNF168 MBTD1 HDAC2 PMC6049856__F1 CAD/POLD2 gene expression is associated with poor overall survival and chemoresistance in bladder urothelial carcinoma CAD UMPS DHODH SET PMC11759867__F1 Action of eCIRP in hemorrhagic shock TREM1 TLR4 MYD88 PMC9468507__F5 Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents CRP AIM2 NR3C1 PMC9675387__F3 Oncology biosimilars: New developments and future directions STAT3 EPOR PMC9376779__F4 Transcriptome changes in stages of non-alcoholic fatty liver disease FNDC5 RASD1 IP6K3 PEG10 STAT5B KLF6 NR3A2 CRYAA NAMPT MYC FOS PMC8431582__F1 From Bipotent Neuromesodermal Progenitors to Neural-Mesodermal Interactions during Embryonic Development ERBB3 NRG1 EDN3 SLIT2 BMP4 WNT1 PMC5793761__F1 Bone morphogenetic protein (BMP) signaling pathway BAMBI SMAD1 SMURF1 DKFZp781O1323 MGP SMAD6 SMAD4 BMPER SMURF2 PMC3922160__F9 Proposed model integrating viral and host biomarkers for disease severity and the effect of IFNB in HAM/TSP STAT1 CD80 CD19 FOXP3 REL HBZ PMC7694276__F2 NcRNA involvement in thyroid cancer-related signaling pathways CDH2 HK2 AKT3 CXCL16 MTOR SCAI FOXN3 FGF2 CTNNB1 VHL ADAM9 ERBB2 CCND1 PMC6290322__F4 Moderate heat stress induces nerve growth factor (NGF) signaling including downstream activation of AKT and ERK as well as cyclic AMP responsive element-binding protein 1 (CREB1) transactivation CDC42 BAX CRK NGF ARHG ARHA UNK PMC8657787__F1 Protein Tyrosine Phosphatases: Mechanisms in Cancer CCL5 PMC4040598__F5 Model depicting effect of ADAM17 variant on the canonical TGFB signaling pathway ADAM17 SMAD2 SMAD4 PMC8657787__F3 Protein Tyrosine Phosphatases: Mechanisms in Cancer CSK PTEN GRB2 PMC9376779__F1 Transcriptome changes in stages of non-alcoholic fatty liver disease RASD1 FOSB WNT3A KLF6 CD36 SCD ME1 FGF7 THRSP IGF1 TRIB1 PKLR ACE2 SLC25A25 PMC7801189__F2 Mechanism of cytokine storm caused by SARS-CoV-2 IL33 ACE2 IL1B PMC9376779__F3 Transcriptome changes in stages of non-alcoholic fatty liver disease PPARG PML F11 SREBF2 HIF1A CXCL10 HMGCS1 IGF1 HMGCR PEG10 SHBG FOXO1 FOXO3A NR5A2 PMC3735707__F3 Maternal factors required for oocyte developmental competence in mice CD2 TK1 MOS PGR C2 SMC3 KL PTEN MYT1 PMC2417189__F8 Inhibition of neurogenesis and axis duplication by mkrn2 via PI3K/Akt signaling pathway GSK3B MKRN2 CTNNB1 PMC7220691__F4 KEGG pathway of pathways in small cell lung cancer BAX MALL POLK CASP3 CDK2 PTEN MYC SKP2 FHIT APAF1 PMC4131183__F3 TRAIL-induced apoptosis MADD BAX DEDD FADD PMC6905101__F5 Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling STAT3 SRC PMC9392297__F2 Toll-like receptors and their role in neuropathic pain and migraine TIRAP MAL TLR9 IRF3 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TLR4 RELA TLR7 TLR10 PMC6771225__F3 Rational combinations of PARPi with other targeted agents CGAS WEE2 EGFR IRF3 MTOR PMC7874138__F3 HCC cells by SIRT4 KLF4 STAT3 ACAT1 GNPAT FASN SIRT4 ARG1 MTOR TRIM21 PMC3779140__F3 DNA damage tolerance pathway (DDT): lesions (yellow Square) in the DNA template blocks progression of high-fidelity replicative polymerase resulting in stalled replication forks RAD18 PCNA USP1 POLG POLN PMC7411231__F1 Regulatory interactions of the HSC model CYCS GSK3B CDKN2D GFI1 CTNNB1 BMI1 CDKN2A CCNE1 CDKN1A CDKN1B ATM CDKN1C TPO MDM2 CCND1 PMC3779140__F4 Proposed model for TLS pathway RAD18 PCNA USP1 PMC3779140__F2 DNA damage signaling at replication forks TOPBP1 ATR ATRIP H2AX RAD17 MDC1 PMC3779140__F5 TLS synthesis in ICL repair by Fanconi anemia (FA) pathway: replicative DNA polymerase stalls upon encounter of an interstrand crosslink (ICL) in DNA ERCC1 FANCD2 RAD51C REV1 BRCA2 FAAP24 FANCL PALB2 SLX4 EME1 PMC3916571__F7 The signaling transduction throughout integrin engagement by Cp aged under oxidative conditions RAF1 CRKL HEL-S-28 PTEN JAK1 SRC CTNNB1 CP PMC7332542__F2 Genetic modifications for the establishment of a reductive, carbon dioxide fixing, and redox-neutral pathway from extracellular glycerol to extracellular SA in S HEL60 HEL-S-32 MDH2 ADH5 PMC3999169__F1 Roles for TNF-Receptor Associated Factor 3 (TRAF3) in Lymphocyte Functions CD40 TRAF3 TRAF2 PMC8663543__F1 CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases TF LPA TH GRAP MAL GLA CIT PMC6662509__F3 PPAR signaling pathway and DEGs.Abbreviation: DEGs, differentially expressed genes LPL UBC CYP8B1 FABP1 UCP1 PLTP ME1 PMC7646253__F5 A3 activation of BER and MMR FEN1 GC UNG PMC3555201__F3 HMGB1 in the tumor microenvironment and hypothesis of HMGB1 functioning via NF-kB and epigenetic pathways STAT3 HMGB1 BRMS1 TLR4 RELA TRAF6 KRAS IRAK4 MYD88 PMC11495063__F4 Metabolic pathways enriched by DEGs between the EPG and PPG SDHA SDHB HEXA PDX1 NEU1 PC MINPP1 ACSS1 MCEE PMC3594407__F8 Signaling pathway by which Beta-catenin may regulate intricate inflammatory responses in liver IRI STAT3 GSK3B IRF3 PTEN LBR PMC6458269__F1 In response to various stimuli such as infection or injury, mucosal epithelial barriers express a range of signals that ILC2s can integrate VIP IL25 TSLP IL33 PMC7137211__F1 PI3K/AKT/mTOR axis and its alterations in breast cancer TSC2 FGFR1 PTEN PMC9523578__F1 Bacterial effectors mimicking ubiquitin-proteasome pathway tweak plant immunity ETS2 BAK1 PMC7485553__F1 ACE and ACE2 in the pulmonary system and the tentative role of SARS-CoV-2The top right part of the figure shows the activation of the Spike (S)-protein of SARS-CoV-2 by predominantly TMPRSS2 and also other host proteases such as trypsin and furin TMPRSS2 FURIN ACE2 PMC8639577__F2 The PD‐1/PD‐L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions ZAP70 ICOS CD80 PLCG1 APC PTEN VAV1 MTOR SKP2 PMC4449713__F4 Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy RHEB TSC2 TSC1 ULK1 ULK2 PMC2423292__F6 Musashi1 signaling in mammary progenitor cell proliferation DKK3 MSI1 CCND2 NUMB CCND1 HES1 CTNNB1 PMC4270133__F5 Applications of DRS PDX1 KRAS PMC4982223__F1 Signaling network of drug-induced glioma differentiation STAT3 GFAP CCND1 PMC4801359__F2 miTALOS v2: Analyzing Tissue Specific microRNA Function NR1D1 F2 APC RHO INS DOCK1 PMC8509322__F3 Adaptive Mechanisms of Halophytes and Their Potential in Improving Salinity Tolerance in Plants SOS1 SOS2 CLC PMC9319223__F2 Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation ND1 FAS ND4L COX1 ND4 MPO CYB KEL COX2 ND6 COX3 ND3 ND2 NRF1 PMC11397273__F4 Ubiquitination- and de-ubiquitination-regulating components related to milk fat synthesis LPL ACSL1 DGAT1 RNF5 SCD FASN MUL1 ACACA VPS28 PMC11397273__F5 Model for the promotion of milk fat synthesis in dairy cow mammary cells through the ubiquitination pathway by soysterols and myristic acid DGAT1 CD36 FASN MTOR PMC10779699__F2 Proposed model for the pathogenic role of the NLRP3 inflammasome signaling pathway in RA and its clinical implications as the therapeutic potential PTX3 GSDMD NLRP3 TNF IL18BP PMC7072717__F1 Store-operated Ca2+ entry pathway (SOCE) ORAI1 STIM1 TRPC4 TRPC1 PMC8818415__F9 Bioinformatic Analysis of the Effect of the Sirtuin Family on Differentiated Thyroid Carcinoma CAD ATM CYC1 PTEN ING1 PMC8150801__F1 Sex Hormone Receptor Signaling in Bladder Cancer: A Potential Target for Enhancing the Efficacy of Conventional Non-Surgical Therapy CDH2 CD24 ATR RAB27B FOXO1 EGFR CHEK1 ATF2 CTNNB1 PMC5863151__F1 Estrogen pathway in lung carcinogenesis and its implications for targeted therapy TH EGFR HEL-S-11 CXCR4 PMC11049926__F4 General model of neuroinflammation in epilepsy IFNG IL6 CCL5 CXCL10 CCL2 TNF IL1B PMC7767648__F4 Suppression of ARID1A associated with decreased CD8 T cells improves cell survival of ovarian clear cell carcinoma ARID1A CRAT MRPS35 ITGB4 STMN3 THY1 RPS27A ACTN2 VEGFA FMR1 NRG1 RPS3 NF1 RPL29 MYH9 PPARGC1A NOTCH1 PMC8818415__F8 Bioinformatic Analysis of the Effect of the Sirtuin Family on Differentiated Thyroid Carcinoma PIR GLA BOK PTEN HEL-S-11 MTOR PMC11988686__F2 Perilla frutescens terpene synthesis pathway; (B,C) P IPP HMGCR MVD MVK PMC8841724__F1 Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives TDO2 IDO1 AHR IDO2 PMC5726781__F4 MELK promotes melanoma growth by stimulating the NFKB pathway HDAC3 NCOR2 HDAC1 MTDH NCOR1 SQSTM1 HDAC2 AATF PMC5647180__F4 Identification of differentially regulated genes within the cellular assembly and organization, cellular function and maintenance and cell death and survival network AGRN RABL6 PDPK1 TUBB4B SYNM AHSA1 PHLDA1 SRPX NDUFAF4 MEF2C PMC8784382__F2 Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases STAT3 RIPK2 NOD2 NOD1 ATF4 EIF2A JAK1 XBP1 TRAF2 PMC5726781__F7 MELK promotes melanoma growth by stimulating the NFKB pathway NF1 BRAF NRAS SQSTM1 PMC2652397__F1 Dual Roles of Nrf2 in Cancer RBX1 KEAP1 MAF PMC3265777__F2 Context-dependent regulation of Rho GTPase signaling LIMK2 ECT2 RHOB CASP3 PMC8473072__F7 MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes JUN JUNB FOS PMC10604999__F1 Scheme illustrating the main hippocampal mechanisms observed in the diabetes-related depression BAX BAD TLR4 GC HEL-S-11 BDNF MYD88 PMC7874138__F6 Breast cancer by SIRT4 STAT3 SIRT4 IL6 PMC8717717__F2 Transcriptomic analysis of patient plasma reveals circulating miR200c as a potential biomarker for high-grade serous ovarian cancer PIK3CA HEL113 PLCG1 WNT16 AGO2 FHOD1 MARCKS EDNRA PTEN VEGFA PTPN13 PMC6166072__F8 Phospholipase D signalling KEGG pathway indicating up‐ and down‐regulated differentially expressed genes in livers of male and female MO‐F1 vs SYK EGF ARF1 MTOR RHO INS RHEB LPA TSC2 TSC1 FYN GRB2 LPP GAB2 AVP PMC7133421__F5 Graphical representation of the PI3K-Akt-mTORC1 signaling pathway TSC2 TSC1 PTEN PMC6166072__F6 Insulin signalling KEGG pathway indicating up‐ and down‐regulated differentially expressed genes in livers of male and female MO‐F1 vs BAD FAS MTOR PDK2 INS EIF4E RHEB CRK TSC2 TSC1 INSR GOPC GRB2 PMC11976707__F2 Key molecular alterations and signaling pathways involved in the pathogenesis and progression of gastric cancer, along with selected targeted therapies (adapted from Lei et al DKK1 APC PTEN MTOR CTNNB1 FGFR2 PMC8560752__F7 There might exist a constrained workflow model among ERA, ARSD, and Hippo/YAP pathway LATS1 TEAD2 TEAD3 TEAD4 PMC6642231__F1 The folates and the one-carbon cycle (1-CC) DHFR PMC7565347__F4 Molecular interactions of ZIKV and DENV with the type-I IFN pathway STAT1 STAT2 IFNAR2 IRF9 IFNAR1 ISG15 JAK1 TYK2 PMC8245133__F6 The putative TAC-induced pathway that culminates in left ventricular hypertrophy PIEZO1 TRPV2 GATA4 PMC4046017__F4 Inhibition of IFNg signaling by MAP PTPA EEA1 PMC11705062__F4 Impact of lysine succinylation on signal transduction FBN1 S100A10 NOTCH1 PMC5810219__F5 Canonical Wnt pathway regulates gene expression by modulating Beta-catenin levels APC FZD7 LRP5 LRP6 LEF1 CTNNB1 PMC6959120__F1 Simplified autophagy signaling pathway and regulation ATG3 ATG12 ULK1 TFEB MTOR ATG5 ZKSCAN3 PMC7904591__F1 Trained Immunity and Reactivity of Macrophages and Endothelial Cells CIC NLRP3 CD36 TLR4 HK2 NOD2 LDLR HIF1A IGF1R MTOR PMC8891570__F1 Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease ATG101 ATG12 PMC9024672__F2 Oxidative Stress and Ischemia/Reperfusion Injury in Kidney Transplantation: Focus on Ferroptosis, Mitophagy and New Antioxidants FTH1 GSTM1 SLC40A1 KEAP1 GPX4 GCLM NQO1 SRXN1 PMC8376648__F8 Proposed working model IGF2BP2 STRAP PMC5445660__F2 Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras SLC3A2 BRIP1 PPM1D IGF1R FANCL MTOR CS HEL-S-51e FANCA FANCC FANCE FANCG MDM4 FANCF MAPKAP1 SPAST MDM2 NGLY1 NRF1 DDI2 MTHFD2 LMO2 HK2 LDB1 FURIN UBE2T MLST8 RICTOR NPRL2 C16orf35 PMC8718194__F2 Crosstalk between the caspase family and the cGAS‒STING signaling pathway TBK1 CGAS IRF3 APAF1 IL1B PMC8718194__F1 Crosstalk between the caspase family and the cGAS‒STING signaling pathway BAX CGAS IRF3 IRF7 PMC4377108__F2 Regulation of Molecular Pathways in Ischemia Reperfusion Injury after Liver Transplantation MAX ATR OCEL1 SMAD4 HIF1A TCF4 MYC RBL1 FANCD2 TCF3 HIPK2 ATM MDM2 LEF1 PMC3808753__F1 Coordinated action of glial and neuronal purinergic receptors and purines in the CNS LIF BDNF PMC7768132__F3 Regulatory mechanism of KRT19 expression in HCC EGF JUN HGF EGFR PDGFRA SRC KRT19 UNK PMC3428061__F2 Interface between hemostasis and adaptive immunity TF CD40 TH CXCR3 S1PR1 SPHK1 GC PLG PF4 PMC2923204__F2 Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease ARC MTOR BDNF PMC11908050__F1 Glioblastoma signaling pathways SYK MYB BAD RBL2 PTEN CD19 MTOR ME1 RAC1 EIF4E RHEB BCR GRB2 PMC7789326__F4 SHMOs exerting anti-inflammatory effects in NEC NLRP3 TLR4 IL6 IL1B PMC4163377__F1 MicroRNA and their involvement in oncologenic signaling cascades in pancreatic cancer RAD51 EGFR BRCA2 BRAF SMAD4 MTOR MYC KRAS CTNNB1 CDK6 BCL2 MDM2 CCND1 CDK4 PMC7270402__F1 Immune landscape of the HBV-based tumor microenvironment CD80 APC LAG3 PMC5855642__F1 Sphingolipid signaling pathway S1PR3 SPHK1 PMC4618289__F1 MTOR pathway as a central signaling pathway causing malformations of cortical development and epilepsy RHEB TSC2 TSC1 NPRL2 C16orf35 PTEN PMC5855642__F2 Transformation of SphK/S1P/S1PRs signaling S1PR1 S1PR3 SPHK1 PMC7780621__F3 Role of cytokines/chemokines on tumor progression and dissemination CXCL12 VEGFC CCR7 MUC1 IL8RB VEGFA CXCR4 PMC4125008__F1 current targets of nuclear DNA repair pathway proteins and their functions XPA RAD51 MSH2 FEN1 PARP1 MGMT PMC8997978__F4 Label-Free LC-MS/MS Analysis Reveals Different Proteomic Profiles between Egg Yolks of Silky Fowl and Ordinary Chickens NPFF PRH NPY PRLHR AVP PMC6033950__F6 EE2 and LNG affected the phosphorylation of proteins involved in brain development, synaptic plasticity, neurogenesis, synaptic transmission, and calcium ion homeostasis although the specific phosphorylation profiles varied SCN8A HEL113 RIMS1 OC90 ZP3 SIX4 SETDB1 ABCA1 OTOF MEF2C KMT2A MBP ARID1B TTN AHI-1 RYR1 SPEN RGS14 SIN3A BASP1 ANK2 CACNA1B APC TRPV1 PTGS2 ESCO2 IGSF9 MKI67 RBL1 EXOC3 TSC2 PKD1 MAP1A PLXDC2 SCG2 PBR CREBBP ENO1 CSPG4 PMC6885271__F5 Proposed schematic diagram of LPS-induced ROS-mediated neuroinflammation, neurodegeneration, and memory deficits via dysregulation of the JNK/NFKB/Akt signaling pathway GFAP GSK3B SNAP25 IL1B PMC5408006__F3 Toll-like receptor signaling pathways TLR1 TLR3 TLR4 NFKB1 TLR9 IRF3 IRF7 TLR7 TRAF3 TLR10 IRAK4 MYD88 PMC7565446__F3 Thyroid hormone synthesis pathway (modified from hsa04918) TH TSHB PLCB4 CANX TSHR GPX4 HEL111 ASGR2 SLC26A4 PRKCB DUOXA2 ALB GNAS ADCY9 DEHAL1 ITPR2 TPO ATF4 ADCY6 CREB1 PDIA4 HEL-S-89n DUOX2 ATF6B TG TTF2 HEL-S-125m ADCY3 PLCB1 PLCB2 ADCY1 HEL-75 PMC2519632__F6 Proposed model of KSHV-induced lymphatic reprogramming of endothelial cells STAT3 PROX1 PMC6089768__F11 miRNA-145 inhibits myocardial infarction-induced apoptosis through autophagy by Akt3/mTOR signaling pathway in viv and in vitro AKT3 MTOR ATG5 PMC8167159__F2 Strategies to tackle RAS-mutated metastatic colorectal cancer EGF CDK6 EGFR PTEN MDM2 MTOR CD47 CDK4 PMC3997659__F1 Role of Ub and SUMO modification of PCNA RAD18 POLL REV1 PCNA PMC7734173__F1 Endosomal and cytosolic DNA sensors and their related signaling pathways TBK1 CGAS MAVS MRE11A DHX36 IL16 DDX41 AIM2 IRF3 IRF7 PMC7718081__F8 Chronic ethanol exposure on the expression of GLT-1 and neuroplasticity-related proteins in the nucleus accumbens of alcohol-preferring rats HMGB1 ARC BDNF PMC3549535__F3 Innate immune stimulation by LPS positively impacts T cell priming HEL-S-92n CD80 TLR4 TNF MYD88 PMC4451963__F1 Wnt/Beta-catenin signaling pathway BCL9 APC LRP5 LRP6 PMC5540157__F1 The Shh signaling pathway SUFU PTCH1 SHH SMO CCNB1 SRC PMC11727972__F6 Bile acids (BAs) regulate cancers via the farnesoid X receptor (FXR) MMP7 STAT3 EGFR SOCS3 MUC4 MTOR SRC RUNX2 PMC6125328__F1 Signaling via MALT1 downstream of various receptors and CARMA/CARD proteins SYK BCL10 BCR OSCAR HEL-S-11 SRC CYLD CARD9 PMC6125328__F4 CARMA/CARD-dependent and-independent MALT1 activation ICOS PLCG1 BCL10 BCR PLCG2 CTLA4 PMC8402453__F4 Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development TBK1 CGAS IRF3 PMC4546272__F3 Impaired Cell Cycle Regulation in a Natural Equine Model of Asthma CDC2 CDC20 RASSF1 APC CDK2 CS PLK1 SKP2 PMC9412366__F2 Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections TBK1 NLRP3 STAT2 IRF9 IRF3 JAK1 TYK2 PMC3795378__F2 Tumor (SVZ) micro-environment CXCL12 GDNF SHH BMP7 BDNF PMC7113505__F2 microRNA (miRNA)–gene–pathway network based on miRTarBase and WikiPathways as described in the Methods section STAT3 TIMP1 TGFB1 SMAD2 SMAD4 PTEN HIF1A TGIF1 MYC SPI1 CTNNB1 TGFBR2 STAT1 INSR FGFR1 KDR CCND1 CDK4 MAPK1 CCND3 BAX ROCK2 RAB14 FASN VEGFA IL6 ARHA HDAC1 SMURF1 TSC1 IGF1 FOXO1 BCL2 NLK PMC8998820__F4 Natterin-Induced Neutrophilia Is Dependent on cGAS/STING Activation via Type I IFN Signaling Pathway NLRC4 CGAS NLRP6 IL1B MYD88 PMC3429585__F1 DKK1 as a novel target for myeloma immunotherapy CD40 CD80 CCR5 DKK1 CCR6 CCR7 PMC8588554__F7 Diterpenoid Compounds Isolated from Chloranthus oldhamii Solms Exert Anti-Inflammatory Effects by Inhibiting the IKK/NFKB Pathway TLR4 CD14 PC TRAF6 LBP MYD88 PMC6521797__F2 Siglec-7 mediated inhibition of NK cell cytotoxicity towards tumor cells SYK MICA MICB SRC PMC5752241__F6 The WNT signaling pathway activated by PRP DKK1 APC GSK3B LRP5 LRP6 NFATC1 CCND1 CTNNB1 PMC7493839__F3 Application of CRISPR-Cas9 in construction of TCR and CAR T-cells IL-21 FAS B2M CTLA4 LAG3 PMC11310285__F1 Hypoxia signaling pathway TF HIF1A VHL PMC3077564__F3 Activation of glia and neurons in the dorsal horn of the spinal cord after peripheral injury ADRBK1 NRG1 CX3CR1 CCR2 ERBB2 BDNF CCL2 PMC11310285__F2 Hypoxia pathway proteins-microRNA-phosphodiesterase crosstalk in steroidogenesis regulation PDE2A STAR CYP17A1 CYP11A1 HSD11B2 HSD11B1 HIF1A PMC11889408__F1 IL-6 family cytokine signaling pathway TF STAT3 CNTF OSM LIF SOCS3 MTOR ERAS PMC12073115__F4 Mammalian RNA-dependent mRNA amplification is enabled by the integrated stress response ATF5 DELE1 ELF2 OMA1 ATF4 PMC7004969__F1 Selected important players of osteoblast differentiation DKK3 CCL3 MSC PTH PMC11997338__F9 Working model showing a positive role of DSP in the migration and endothelial differentiation of DPSCs through DSPaa34–50–ENGZP association and subsequent activation of AKT1 signaling pathway ENG ANGPTL4 FLT1 THBS4 PMC8957861__F1 How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment CRP TF HEL-S-62p PLG CP PMC8423996__F2 GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism SOCS1 ADAM17 SOCS3 ACE2 PMC4117634__F9 Macrophage-Activating Lipopeptide-2 Requires Mal and PI3K for Efficient Induction of Heme Oxygenase-1 BTK KEAP1 MAL MYD88 PMC6428452__F8 p38gamma MAPK-promoted EMT SUZ12 ERBB4 ERBB2 GATA3 PMC12210305__F6 High-temperature stored soybean meal on MAPK and FOXO signaling pathways in broiler jejunum tissue MAX PRMT1 STAT3 EGF KLF2 JUND FAS TRADD CYC1 SMAD4 BNIP3 PTEN INS SKP2 FLNA MEF2C ATM MDM2 PROC ECSIT MCC CD14 TNF CDK2 NLK PMC4646664__F1 Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics RPS6 TSC2 TSC1 C1GALT1 PTEN EIF4E PMC7033549__F9 A working model depicting the relationship between proline and polyamine in wild type, PvP5CS OE and RNAi transgenic plants under control and salt stress conditions PRODH PMC3726361__F4 Focal adhesion signaling pathway highlighting those genes that are differentially expressed compared to untreated control ovaries and identifying by color the treatment group(s) from which the differentially expressed genes came JUN BAD VASP FYN INHBA PARL HEL-S-28 PTEN ARHA FGF2 PMC4994475__F1 Network of reported candidate genes associated with GTS KCNE1 SLC1A3 CTTNBP2 ADRA1A KCNE2 BTBD9 PSEN1 MRPL3 MYC SLITRK1 LHX6 DRD3 DLGAP3 CTNNA3 NR1C1 DRD1 HDC NR2A1 DRD4 PSEN2 ADRA2C HEL-S-1 NRXN1 RCAN1 PMC3304298__F1 AKT signaling pathway BAX SYK BAD GAL HEL-S-28 PFKFB2 PTEN CD19 MYT1 MTOR IRS1 TSC2 RICTOR TSC1 BCR LYN MDM2 JAK1 GAB2 CCND1 PMC9277406__F1 Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs UGT1A1 APC CYP3A4 PMC3518872__F4 Three IPA Canonical Signaling Pathways: CD40, IL-1, and Chemokine Signaling in TGFB1+LPS+IFNGamma-treated astrocytes ECSIT CD40 STAT3 LTA ROCK2 FCER2 CCR5 MAPKAPK2 CCR3 ARHA TRAF3 RHO TRAF6 MYD88 MAP3K7IP1 TRAF5 ATF1 TRAF1 JAK1 CXCR4 TRAF2 UNK PMC2726075__F1 EGFR signaling pathway EGF MYC CCND1 PMC2766677__F7 Proposed scheme of the signaling pathway leading to immature dendritic cell chemotaxis upon exposure to M-tropic gp120 CCR5 PMC3518872__F3 Top three networks of significantly associated molecules in TGFB1+LPS+IFNGamma-treated astrocytes SNRK MPDZ CRCP MPV17L SH3BGRL2 SEPHS1 DNAJC3 MORC3 MANEAL RCN3 RABEP2 PDE1B SRM ZNF318 RNF34 KLF9 CH25H KIF3C RRM2B ZNF346 TPRKB NPM3 CORO2B HTT MIS18A TMEM43 MSH6 SERPING1 DAP3 GLO1 AEN WLS GM2A VAPB POLR3E ENO3 MLF2 COL16A1 TP63 SESN1 TP53RK HEL-S-64p NINJ1 DDIT4 KCNJ12 ETHE1 GLRX TNFRSF10A NFATC2IP TPR GTSE1 KCNK2 SLMAP LITAF SEZ6 CSN3 APOBEC3B MTUS1 OSGIN1 ZNF365 PLAGL2 KRT23 PHGDH C2 HEL-S-75 SLC2A6 LGALS4 SCN3B PMC3518872__F6 GPCR Canonical Signaling Pathways ADRA2A CAMK4 GRB2 SRC PMC491841__F1 Consensus model of the cell cycle control mechanism in budding yeast SWI5 CIB2 CDC20 APC NET1 PMC7311199__F3 DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer RIPK3 TBK1 CGAS GSDMD NLRP3 MLKL AIM2 RIPK1 IRF3 DFNA5 PMC5122382__F9 Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule MTOR CDK4 PMC5746573__F2 Ca2+ and ROS crosstalk between ER and mitochondria, with emphasis on redox control of the MCU MCU C6orf79 HEL-S-64p PMC11915041__F4 Research progress on the role of decorin in the development of oral mucosal carcinogenesis TIMP3 IGF1R VEGFA DCN PMC5346035__F1 PharmGKB summary: macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics ORM1 SLCO1B1 CYP3A4 ABCC2 ABCB1 PMC7015241__F10 Working model describing how MYPN and PALLD may promote SRF signalling PALLD MYPN PMC3545835__F1 Principal platelet membrane receptors and signal transduction pathways VWF SYK PLCG2 PMC3669920__F1 Schematic of neuregulin-ERBB4 signaling showing the roles of the products of the selected genes EGF NRG1 ERBB4 BACE1 NRG3 PMC6056829__F1 GPI biosynthesis in yeast GPT PMC5393394__F5 Network analysis for the RS fraction proteins with increased secretion upon intracellular LPS stimulation HEL-S-22 BAX SERPINC1 HEL-S-128m FCGR3A HLA-DRB1 CD14 FABP4 B2M GMFB PMC9317051__F3 Resistance and Implications for Treatment Strategies in Chronic Myeloid Leukaemia STAT3 BCR CRKL EZH2 SMO GRB2 MTOR JAK1 GAB2 SET CTNNB1 PMC3269020__F3 Role of miRNAs in aging of mice SP1 IGF1 BCL2 IGF1R SIRT1 PMC3269020__F1 Pathways involved in aging COQ7 MAP2K4 IGF1 PTEN IGF1R NRF1 PMC5422712__F8 CD40-mediated apoptosis in carcinoma cells CD40 BAX TRAF1 TRAF3 PMC9936654__F10 Transcriptome analysis of Populus × canadensis ‘Zhongliao1’ in response to low temperature stress ERCC1 XPA RBX1 LIG1 CETN2 CDK7 PCNA CCNH XPC PMC11722408__F2 Mesenchymal Phenotypes Utilize Autocrine and Paracrine Signaling to Reinforce SCLC Subtypes PTPRM ENHO TH EGF JUN PTN SP1 AXL MPZ L1CAM KIT CD46 SPP1 AGRN YBX3 TPD52 PEMT CSPG4 HES1 PMC10379601__F5 Hypocholesterolemic Potential of the Edible Algae Fucus vesiculosus: Proteomic and Quantitative PCR Analysis CYP51A1 EBP DHCR24 DHCR7 HSD17B7 PMC11098888__F4 CCL1/CCR8, CCL3/CCR5, CXCL6/CXCR2, and CXCL12/ CXCR4 axes in esophageal squamous cell carcinoma CXCL12 GAL CCL3 CCR5 PTEN RHO IL8RB CXCL6 SRC CXCR4 CCR8 CCL1 PMC5554756__F3 Negative regulators of the RIG-I-like receptor signaling pathway TSPAN6 NLRX1 RNF125 MAVS USP15 EZH2 IRF3 TRAF3 SMURF2 PLK1 PMC5554756__F1 Negative regulators of the RIG-I-like receptor signaling pathway TBK1 MAVS USP15 TRIM25 IRF3 TRAF3 TRAF6 TRIM65 PMC5554756__F2 Negative regulators of the RIG-I-like receptor signaling pathway USP25 TRIM13 ARL16 RNF122 MAVS ARL5B TRIM59 RNF125 USP15 USP3 TRIM25 USP2 NOD2 PMC7381287__F1 LPS signaling TBK1 IL10 TIRAP TLR4 IRF3 LBP IL1B MYD88 PMC11979484__F9 Hi-Exos in relieving the senescence of NPCs and IDD AGO2 DDIT4 IL6 PMC10458661__F2 TLR and RLR signaling pathways present in airway epithelial cells in response to viral infections TBK1 TLR3 TLR4 TLR9 TLR8 TLR7 MYD88 PMC2934757__F1A Defining the pathway to insulin-like growth factor system targeting in cancer IGF2R IGF1 IGF1R GRB2 IGF2 IRS1 PMC3720640__F3 Anti-Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance PTPRS PTEN SRC CCND1 PMC5184782__F1 Context-dependent TGFB signaling pathway SIX1 PEAK1 SMAD2 SMAD4 GRB2 SRC ITGB3 YAP1 PMC171388__F7 Model of Cripto’s inhibition of Act B signaling through the Smad2 pathway SMAD2 CRIPTO NODAL PMC10380015__F2 Challenges and Future Trends in Atopic Dermatitis IL1R1 IL33 IL36A TRAF6 IL18BP MYD88 PMC10380015__F3 Activation of the adaptive immune system via various receptors, different interleukins and its receptors, and the Janus kinases (JAK) STAT pathway STAT3 SYK JAK3 STAT1 TSLP BTK TRPA1 IL13RA1 AHR STAT4 JAK1 TYK2 IL13RA2 PMC6580124__F7 Mechanism of rapamycin’s anti-angiogenic and anti-lymphangiogenic effects in melanoma VEGFC VEGFD MTOR VEGFA PMC7915726__F1 The Mer receptor tyrosine kinase (MERTK)-mediated signaling pathway in epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI) resistance STAT3 EGF NRG1 HGF TULP1 EGFR SOX2 PROS1 MTOR SRC MERTK PMC6667871__F8 Schematic model depicting the mechanism of DEPDC1-induced HCC progression DEPDC1 CCR6 CCL20 PMC7915726__F5 MERTK in Yes-associated protein (YAP)-mediated EGFR-TKI resistance MOB1A MOBKL1A EGF FOXM1 EGFR PMC3627331__F1 CD30 signals through TRAFs: upon stimulation by CD30L, CD30 recruits TRAF2 via interaction with its TRAF binding motif, resulting in TRAF2 degradation CD40 TRADD RELB TRAF3 TNF TRAF2 PMC6513092__F7 PIN1and PTOV1 pathway interactions BAX PTOV1 CCNB1 MAPK8 PIN1 CTNNB1 PMC6315738__F1 Intestinal uptake of non-heme iron and its regulation HEPH FES PCBP1 HEL-S-11 PMC12090806__F7 Role of TRIM22 in antiviral immunity TBK1 NLRX1 MAVS IRF3 ELF3 PMC5706953__F1 KEAP1 glycosylation regulates the NRF2 pathway OGA HMOX1 OGT KEAP1 GCLM NQO1 GCLC SLC7A11 PMC4446875__F10 Schematic diagram depicting the conceivable cellular events by which MIOX disrupts mitochondrial integrity under HG ambience, which results in renal tubular cell injury PINK1 FIS1 MFN2 MIOX PMC126171__F5 Different telomere damage signaling pathways in human and mouse cells CDK6 CDK2 CDK4 PMC6171574__F3 Signal transduction initiated by transforming growth factorB1 (TGFB1) BMP1 LOX PMC6037039__F4 Functional mechanisms of lncRNAs in vascular disease KLF2 SPHK1 LARP1 GPR119 EZH2 VEGFA IL1A CCL5 HOXC6 TUG1 DYNLRB2 CX3CL1 HAS2 MDM2 NAT8L PMC4150931__F1 Signaling pathways that induce epithelial–mesenchymal transition (EMT) GSK3B ARHA RHO IMPACT PMC4124648__F2 Possible therapeutic interventions on molecular mechanism inducing necrotizing enterocolitis EGF HMGB1 TLR4 PMC8026578__F2 MicroRNAs in the pathophysiology of addiction MAPK1 GNAI1 ACTG1 GRIA2 RAF1 PPP1CC PRKCB MAPK3 ARAF GNAS CAMK2A HEL-S-80p RAP1A CALM1 MAP2K1 ADCY1 CREB1 PS1TP5BP1 PMC10298332__F4 The TNF signalling pathway by M-glucans MMP14 CSF2 IL18R1 TRADD HEL-S-62p SELE ITCH MLKL LIF IRF1 SOCS3 TNF NOD2 CASP3 FADD PMC6391339__F1 Biogenesis of miRNAs RAN DCP2 DGCR8 AGO1 CCR4 DROSHA EIF4E PMC10298332__F5 The C-type lectin pathway by M-glucans SYK CCL22 RELB IRF1 ARHA MDM2 TNF CYLD CCL17 PMC8615411__SF1 Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues CYP2R1 CYP24A1 CYP27A1 PMC9326176__F2 Cathepsin K+ Non-Osteoclast Cells in the Skeletal System: Function, Models, Identity, and Therapeutic Implications STAT3 BMPR1A CTSK IHH PMC10298332__F6 The IL-17 signalling pathway by M-glucans USP25 IL17RC MCC TAB3 MMP9 TRAF3 TRAF6 IFNG TRAF4 COX2 IL17RB S100A9 FADD PMC9623337__F1 New insights into Chlamydia pathogenesis: Role of leukemia inhibitory factor STAT3 LIF SOCS3 GRB2 JAK1 PMC4729089__F1 Metabolic pathway of monoamine neurotransmitter synthesis and degradation TH PAH PMC3897220__F9 Concept map of Whi5 function tal-1 POLI MIP PMC6216037__F8 Oxidative stress-induced autophagy and endothelial dysfunction BAX BCL2 HDAC6 PMC10951504__F5 Underlying mechanism of obesity and hyperuricemia CRP JUN LEP APOE IL6 TNF INS CCL2 ALB NR1C1 REN HEL-S-162eP POMC APOB GPT PMC5087126__F2 Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways STAT3 TBK1 TRADD STAT2 IRF9 RELB TAB3 IRAK1 IRF3 IRF7 TRAF3 TRAF6 CSF3 IRAK4 MYD88 TLR3 IFNAR2 TLR7 JAK1 TYK2 PMC10951504__F6 Associations between obesity and hyperuricemia combing mendelian randomization with network pharmacology STAT3 LEP TRADD POMC NPY SOCS3 AgRP MTOR TNF TRAF2 PMC7316587__F2 Molecular mechanisms proposed for NHE isoforms in cancer CDC42 EGF HGF EGFR SRC RAC1 PMC8387950__F8 FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARA Pathway NR1C1 NR1C2 GCK ACACA PMC8088471__F7 Periodontitis‐compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA‐378a promote local angiogenesis by targeting Sufu to activate the Hedgehog/Gli1 signalling SUFU PMC11873051__F1 Resistance mechanisms to CDK4/6 inhibitors AURKA CDK6 NF1 FGFR1 ERBB2 CDK2 FAT1 FGFR3 PTEN CDK4 FGFR2 PMC6536409__F7 LncRNA TNRC6C‐AS1 facilitated cell proliferation and inhibits cell apoptosis and autophagy by promoting the methylation of STK4 promoter region via the Hippo signalling pathway LATS1 DNMT3B LATS2 STK4 PMC8999734__F4 Anti-Inflammatory Activities of an Anti-Histamine Drug, Loratadine, by Suppressing TAK1 in AP-1 Pathway TLR4 MMP3 MMP9 MYD88 PMC6148449__F1 SRP54 and a need for a new neutropenia nosology SRP19 EFL1 SRP54 SBDS SRP14 SRP9 HEL103 SRP68 EIF6 PMC6127670__F7 Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry PDHX SDHA GCM1 HSPA12B ACO2 KGD4 DNAJB6 OGDH DLD CS UNK PMC9253705__F40 Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway STAT3 CTSK MMP2 NFATC1 PMC11921819__F4 Ferroptosis in Tumor Immunity SLC3A2 CD36 GPX4 SLC7A11 PMC2014644__F2 PGE2-EP receptor signaling pathways EGR1 EGFR GSK3B CREB1 CTNNB1 PMC11921819__F5 Cuproptosis in Tumor Immunity STAT3 STAT1 HMGB1 CGAS LOXL4 IFNAR1 CCL2 PMC11921819__F1 Molecular mechanisms and crosstalk among five cell death modalities: Apoptosis, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis DLAT ZBP1 NLRP3 LIAS GPX4 LPCAT3 GSDMB FES TNF APAF1 TRAF2 FADD PMC6371813__F1 Protein synthesis and degradation pathways in skeletal muscle FOXO1 IRS1 EIF4E PMC7551806__F1 Putative molecular mechanisms involved in the development of sarcopenia during aging IGF1 SMAD2 IGF1R MTOR PMC3190192__F1 PRL crosstalk with estrogen, progesterone, EGF/TGFA, and IGF-I EGF TGFA PRL PMC11792170__F2 Part of IL-27 signaling pathways in obesity and other related metabolic diseases STAT3 APC UCP1 MTOR ABCA1 PMC7557985__F1 Involvement of p38 MAPK, ERK MAPK, and NFKB signaling pathways in osteoclast differentiation mediated by RANKL and BMP2 DCSTAMP BMP2 PMC7139475__F5 Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea ACHE STAT3 NPY PMC7139475__F2 Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea NGF DCX PAF1 NLRP3 SGK1 GSK3B BDNF SIRT1 IL1B PMC8869474__F1 Tipping the Balance: Vitamin D Inadequacy in Children Impacts the Major Gut Bacterial Phyla NR1i1 CYP2R1 CYP27B1 CYP24A1 DHCR7 PMC3347988__F4 Schematic overview of the pathway controlling translational changes in adipogenesis POLL EIF4B POLI MYC PMC3717195__F1 DNA repair systems ERCC1 XPA ATR PCNA XAB2 PNKP RNF8 ATM TDP1 TOPBP1 ATRIP RAD50 RAD51 FEN1 PARG APTX WRN MDC1 XPC PARP1 DDB2 DDB1 LIG1 MRE11A BRCA1 PMC8564965__F2 Fibroblast growth factor receptor fusions in cancer: opportunities and challenges STAT3 FRS2 PMC8130302__F2 Effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation ROR2 RHO NLK LEF1 CTNNB1 PMC11792170__F1 Some immune cells regulated by IL-27 STAT3 STAT1 FAS STAT2 EBI3 STAT4 TNF GATA3 PMC6208373__F7 Toll-like receptor signalling pathway shows similarities, but also differences between LPS and LPS + IFNG TIRAP CTSK CD14 IRAK1 IRF3 IRF7 IL6 TRAF3 TNF TRAF6 RAC1 TLR1 PIGA PDC MIP FADD PMC6410520__F1 Microbial-based production of nutraceuticals from simple carbon sources IPP STS ASPA PMC9026333__F6 Heparan Sulfate, Mucopolysaccharidosis IIIB and Sulfur Metabolism Disorders CBL CTH pcap HEL-S-64p PMC4870992__F2 Pathogenesis of Hepatocellular Carcinoma TERT MYC PMC4110660__F2 In silico network and pathway enrichment analysis NUP155 GNL2 SMAD2 MYC STUB1 SIN3B RBBP4 ZBTB7A HSPA2 ARID2 HDAC2 IKZF3 DHPS MAPK1 SRP54 MSH6 ZNF485 PRDM15 IMPDH1 HMGCS1 DDB1 USP33 CUL4A BRCA1 PSMC6 CUL4B UBE2E1 PPIF GEMIN5 PSMD2 KPNA2 SSBP2 CTCF DIDO1 ZFR CCNB1 CRBN SPEN IKZF1 PSMD11 UBC TET1 TNS3 MAGED1 NUP153 CREBBP EP300 AHSA1 NFATC3 DNAJA2 SKA3 PMC7766597__F1 Four different types of regulated cell death BAX NLRP1 FAS TRADD NLRP3 MLKL GPX4 AIM2 PMC6526899__F3 Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway COX7B C6 NDUFB8 NDUFB2 NDUFB5 ETFB NDUFA9 UQCR10 NDUFB9 NDUFV2 CYCS CYC1 NDUFA7 NDUFS8 CS NDUFS3 NDUFS4 SUCLG1 NDUFB4 NDUFA3 NDUFB3 NDUFC1 NDUFC2 CCS UQCR11 PMPCB SDHD SDHB ZNF183 COX6B1 NDUFA5 PMC6526899__F4 Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway FH PTCD3 MRPL12 PCCA SLC25A20 MRPS28 DBT OLA1 PCCB MRPL30 MRPL42 DHX58 MRPL20 MRPL9 RTP4 ETFA MRPS15 ALDH3A1 MX2 HEL-S-26 CPT2 KNG1 OAS2 ITIH4 PMC6555965__F1 Schematic diagram of lipid biosynthesis pathway in Schizochytrium sp FAS MAL CIT PMC6526899__F2 Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway GANC CAD PKIA OSBPL6 CAND1 RORA PMC4178034__F3 Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response BPI TRAF6 MYD88 PMC3724874__F7 Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest BAX BAD BCL2 PMC6636202__F8 Illustration of the miR-153 gene pathway in bladder cancer cells STAT3 IDO1 IL6 IL6R PMC3213081__F1 The P2X7 Receptor in Infectious Diseases NLRP3 ARG1 ARHA CEBPB IL1B PMC3162452__F7 Schematic representation of intracellular pathways implicated in the regulation of cholesterol homeostasis and inflammatory response in human macrophages by IL-6 STAT3 ABCA1 PMC5922990__F9 Antiviral properties of naringenin NR1C1 HMGCR VLDLR PMC5954269__F1 Vitamin D Pathways: An Overview (source: Nutrients 2016, 8, 319) CYP2R1 CYP27B1 DBP CYP24A1 PTH CYP27A1 PMC6088103__F4 AD genes selected by cross metrics analysis and their relation with other diseases TGFB1 GSK3B PTGS2 VEGFA IL6 PSEN1 CCL2 NGF AGER TLR4 APP BDNF HEL-S-44 PMC5922990__F6 Naringenin prevents acute and chronic CCl4-induced liver damage BAX KEAP1 MAF SMAD4 FADD PMC5922990__F7 Naringenin in cancer development CSA2 EGF JUN EGFR CDK2 BCL2 GRB2 MMP9 FOS PMC4822554__F1 Glucose promotes tumor growth by activating lipid synthesis and uptake upon N-glycosylation of SCAP EGFR LDLR PMC2778955__F10 Expression of an IKKG Splice Variant Determines IRF3 and Canonical NFKB Pathway Utilization in ssRNA Virus Infection MAVS RELA IRF3 PMC11972266__F2 Isorhamnetin inhibits cholangiocarcinoma proliferation and metastasis via PI3K/AKT signaling pathway SYK MYB BAD EBP RBL2 CYC1 PTEN CD19 SKI EIF4E TSC2 BCR CD37 RXRA PMC7997989__F9 TDP-43 and PINK1 mediate CHCHD10S59L mutation–induced defects in Drosophila and in vitro PINK1 CHCHD10 C9orf72 PMC3427417__F7 Nicotine-induced A7nAChR/JAK2 pathway in cooperation with nicotine-mediated ERK1/2 activation potentiates STAT3 activation in PC cells STAT3 PC CS MUC4 PMC5890734__F1 Overview of Ethylene Biosynthesis and Signaling Pathways in Arabidopsis and Environmental Factors That Modulate Ethylene Signaling EBF2 PMC9547606__F2 Platelets, Macrophages, and Thromboinflammation in Chagas Disease TF PC PMC3085710__F4 KEGG Pathway Map () C6 SERPIND1 CD59 SERPINF2 CPB2 KLKB1 C3AR1 HEL-S-62p F5 F7 CR2 C4A CR1 PLAT F2R F2 F10 F3 PROS1 C9 THBD A2M F8 F9 C4B_2 PROC SERPINC1 C7 SERPING1 MASP2 PLAUR SERPINA1 PLG F11 MASP1 TFPI C2 PMC5997273__F1 Road to Crohn’s disease ATG16L1 EIF2A MYD88 PMC8636012__F1 Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies GLS HK2 FASN PMC4901515__F1 Cilia-mediated signaling pathways whose proper regulation is dependent on the proteasome and the structure of the proteasome SUFU SMAD2 PDGFRA APC SHH SMAD4 SMO PMC11789227__F3 Therapeutic potential of SOX family transcription factors in osteoarthritis SFMBT2 CXCL12 PSMD11 SIRT7 HMGA2 LIN28A SOX9 CXCR4 SIRT1 ELF3 CTNNB1 PMC155638__F3 Hypoxic activation of apoptosis pathways BAD PTEN APAF1 PMC155638__F1 MAP kinase signalling pathways CDC42 ETS2 ATF2 RHO MEF2C PMC3993959__F3 Bioinformatic analyses expose alterations in nucleic acid binding and regulatory proteins SAA1 SARNP RBM22 CHERP CCNC PMC8871586__F8 Gene Ontology Groups and Signaling Pathways Regulating the Process of Avian Satellite Cell Differentiation TMOD1 HEL113 TCAP HEL-S-273 ACTN2 TPM1 MYOM1 ACTN4 tmp_locus_29 TPM3 TTN HEL-S-108 DMD MYBPC3 PMC7539288__F6 NAD+ deficits in aging-associated dysfunction and cancer FOXO1 NAMPT HEL-S-26 PMC9362381__F4 Thrombosis leading to acute abdomen in corona virus disease- 19:A case series VWF VCAM1 ACE2 PMC10744232__F3 Pomegranate (Punica granatum L.) and Its Rich Ellagitannins as Potential Inhibitors in Ulcerative Colitis RPS6 STAT3 IL1R1 MTOR TNF PMC7539288__F1 NAD+ metabolism and its physiological function NNMT NAPRT SARM1 HEL-S-90n NAMPT NNT PMC7539288__F2 Subcellular equilibrium of NAD+ ME3 NMNAT1 NADK PRX NMNAT2 ME1 HEL-S-26 NNT NMNAT3 HEL-S-44 PMC7867045__F3 Genetic alterations leading to HIF activation in GB EGF EGFR PTEN MDM2 PMC3043094__F3 Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach PLN CAV3 CAV2 BCR PMC7089929__F4 Distribution of differentially expressed genes (DEGs) of the cell cycle pathway (dre04110) in diploid and tetraploid states in vitro and in vivo DBF4 RAD21 CDK7 PCNA CDK2 MYT1 PLK1 SKP2 PMC3043094__F4 Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach MAX MAFK NGF JUN BAP1 CD14 GRB2 NLK TNF FLNA TRAF2 MEF2C PMC3043094__F2 Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach DCT TYRP1 CTNNB1 PMC5663837__F4 ErbB signaling pathway and its circRNA-related genes EGF UBE4B BAD TGFA MAN1A2 UBE2G2 ABL2 PIK3R3 EGFR BRAF NRG3 MTOR NRG4 BTC AMFR ATF4 SRC NPLOC4 BAX OS9 JUN UBE2G1 ERBB4 SEL1L CRKL CASP12 UBQLN1 SHE NRG2 NRG1 RBX1 HBEGF ERBB2 SKP1 GRB2 WFS1 PMC3135646__F1 P53 pathway in development, cancer, and reprogramming BMI1 BAX ATR ATM MDM2 MYC PMC11516169__F9 CsEVs in promoting malignant proliferation and metastasis of CCA cells CCND3 CDK6 CDK2 CCND1 CDK4 PMC3049961__F8 Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR MAPK1 PXN EGFR NEDD9 PLCG1 SHB PKP4 TNS3 CDK7 STAT5B ERRFI1 PRKCA CDK3 SRC SDC2 GJA1 PMC7672634__F1 Ingenuity pathway analysis of FGF/FGFR pathway suppressed by cordycepin in MA-10 cells STAT3 CRK HGF MAPKAPK2 GRB2 PMC9249506__F10 Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia–Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response BAX PLK3 BCL2 ATM PMC5133671__F8 Simplified model for how AhR mediates the RANK/c-Fos signaling axis of osteoclast differentiation and bone resorption CYB COX1 COX3 ND4 AHR NFATC1 PMC1383550__F2 Two branches of the class I PI3K pathway CDC42 TF GSK3B PTEN PMC9297732__F6 Multi-pronged anti-cancer activity of PI3KD inhibition in cancer CD40 BCR BCL2 PMC7710361__F5 Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders ABAT KYNU PMC8633417__F2 Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis TLR4 SMO MYC TNF CTNNB1 MYD88 PMC8633417__F1 Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis STAT3 NOS2 MUC2 IL18 TNF PMC11869728__F1 Canonical TGFB/SMAD and Wnt/Beta-catenin signaling pathway SMAD2 APC LRP5 SMAD6 SMAD4 LRP6 CTNNB1 PMC9438347__F14 Plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/Beta-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model TH APC GSKIP GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC1779520__F3 Signaling pathways activated by serum and GF treatments DUSP5 STAT3 SPRY4 JUNB SOCS2 SOCS3 SPRY2 PTPRO PITPNC1 SOCS5 GADD45B GRB2 SRC YWHAG PMC5705586__F3 Fibroblast Growth Factor 2 as an Antifibrotic: Antagonism of Myofibroblast Differentiation and Suppression of Pro-Fibrotic Gene Expression SMAD2 SMAD4 TGFBR1 PMC4959856__F6 VNN1 expression and function can be regulated by Ox-LDL to promote atherosclerosis VNN1 ABCG1 NPC1 VCAM1 ABCA1 PMC2804818__F5 A summary of the ligand-mediated control of TRP53 expression via the PI3 kinase/AKT/MDM2 pathway PI3 PMC7567487__F2 Mammarenavirus life cycle TFRC NRP2 NPL CD63 PMC8886606__F2 Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook BTK TRADD TIRAP JAK3 CD14 TANK JAK1 TRAF6 TRAF2 MYD88 PMC2990745__F1 Examples of pathways shared by a signature hub from the Wang dataset and a signature hub from the Desmedt dataset FAS RPL34 CD14 EPO RPS7 RPS29 RPL17 RPS13 RPS17 RPS25 RPL9 GCK RPL26 PMC8886606__F1 Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook CXCR3 FAS IL1B PMC6121189__F6 Prolactin-driven signaling pathways via the short or long prolactin receptors PRL GRB2 CCND1 PMC4711587__F3 De Novo Assembly and Characterization of Early Embryonic Transcriptome BAMBI SOST NLK GAS1 ZIC2 PMC8150799__F4 Physiological and Pathological Inflammation Induced by Antibodies and Pentraxins CRP TBK1 SYK TNF IL1B PMC7784492__F3 Pathways affected by mutations STAT3 NF1 FGFR4 CDK2 PTEN CDK4 PMC3264379__F9 Proposed model for regulation of HCV replication mediated by the Ras/Raf/MEK pathway STAT2 IRF9 JAK1 TYK2 PMC8804383__F7 Curcumin Ameliorates Cardiac Fibrosis by Regulating Macrophage-Fibroblast Crosstalk via IL18-P-SMAD2/3 Signaling Pathway Inhibition SMAD2 IL1B PMC6230569__F4 miRNAs modulating dendrite morphogenesis converge ARHG LIMK1 MIB1 SOX2 ARHA BDNF RAC1 PUM2 PMC2587303__F1 mTOR inhibition as a Therapeutic Strategy in the Management of Urologic Malignancies RHEB TSC2 RICTOR TSC1 SMAD2 RHO MTOR IRS1 PMC4383161__F2 Integration of the 3 major pathways that regulate skeletal muscle mass PCNA GSK3B MTOR PMC5995256__F5 Pathways altered in brain metastases compared to primary NSCLC RHEB TSC2 BAD TSC1 MCL1 HEL-S-28 PTEN CDC37 GRB2 CTNNB1 EIF4E PMC11047590__F1 Redox systems involved in microglia RBX1 NLRP3 KEAP1 TXNIP GPX4 PRX SLC7A11 HEL-S-64p CTNNB1 PMC11047590__F2 Redox regulation of immunometabolism in the polarization of microglia in DR RHEB NGF TLR4 FES PTEN MTOR PMC3966620__F1 Cl− channels in cardiac myocytes CLCA1 CFTR PMC3778395__F1 Plant tetrapyrrole biosynthetic pathway POR HMBS CPOX PRX FECH UROD UROS PMC11506738__F3 Key pathways of COVID-19 vaccine-induced adverse immune reactions TH APC MRGPRX2 PMC11506738__F4 Various mechanisms of adverse immune activation by COVID-19 vaccines IFNG CGAS IL13 TLR9 TLR8 IL4 IRF3 IRF7 TLR7 IL5 TNF PF4 PMC5679221__F2 Glia unglued: How signals from the extracellular matrix regulate the development of myelinating glia CDC42 FYN IGF1 HEL-S-28 GRB2 MTOR RAC1 PMC5679221__F1 Glia unglued: How signals from the extracellular matrix regulate the development of myelinating glia CDC42 FYN HEL-S-28 ARHA RAC1 PMC6566438__F7 Some of the signaling pathways involved in the differentiation of ADSCs into IPCs STAT3 GLP1R IRS1 PMC8355044__F1 Functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy CD44 TLR4 EGFR PEG3 ARHA MTOR VEGFA PMC6875034__F6 STRING analysis of integrin signaling pathways and response to wound healing pathways EHD2 CD59 P2RX4 MYOF FLNB CD36 EGFR ANXA2 HEL-S-7 S100A8 FAP HEL-S-30 ITGB3 FLNA ITGAV HEL114 SERPINE2 PRCP ACTN4 CD9 MYL12A MYH9 HEL-S-102 PMC9556788__F7 Chronic heat stress induces the disorder of gut transport and immune function associated with endoplasmic reticulum stress in growing pigs NAPA EHD2 AK3 C1QB C1QBP POR GDI1 C9 SYT2 ATP10B CACYBP UBE2V2 GOLPH3 MASP2 TPK1 PYGB LRRFIP2 RPS7 SDHB HEL-S-115 CFP C4BPA KIF21A FCRL6 MARS1 CARHSP1 TMIGD1 LYPD8 CP ACLY UBE2L6 HEL-S-62p AP1S1 C4A TRIM21 SUCLG1 TNFRSF17 MYO1C EIF4A2 CLTC VPS36 TRIM31 RPS6 TNLG1B FH SOCS4 KIF1B SRP68 SEC23B IARS2 FKBP4 C1QA C2 ACADL DENND4C PMC8616071__F1 Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors ERCC1 CDC2 CCND3 RAD51 CDK6 BRCA1 RRM2 ATM ME1 CDK4 PMC9095352__F7 Inhibitory Effect of Ursolic Acid on Proliferation and Migration of Renal Carcinoma Cells and Its Mechanism SUFU PTCH1 SHH SMO PMC5070718__F1 Levels of miR-146a and miR-146b are regulated by innate immune signaling STAT3 TLR3 CARD10 TLR4 IRAK1 CCL5 TRAF6 CCL20 PMC5378112__F1 Genetic model of the insect melanin biosynthesis pathway () TH AANAT DDC PMC6820234__F1 Heme biosynthetic pathway and experimental porphyria models HMBS CPOX ABCB6 AIP ABCG2 FECH DDC UROD UROS CTNNB1 MPO PMC4380839__F1 ROCK and Rho LPA PMC3998841__F2 Inflammatory cytokine-associated idiosyncratic drug hepatotoxicity as a “network toxicity” BAX CASP6 TNF PMC3767467__F4 Proposed model of TRP47 effector function in E FYN PCGF5 PMC8657105__F5 Histopathological and Molecular Profiling of Clear Cell Sarcoma and Correlation with Response to Crizotinib: An Exploratory Study Related to EORTC 90101 “CREATE” Trial MSH6 MSH2 ERBB2 SET PMC7872968__F7 Phagosome maturation pathway, (B) RIP1 and ECSIT signaling pathway, (C) arachidonic acid metabolism pathway, and (D) cytotoxic T cells signaling pathway using CD226 and PVR axis ECSIT MAP3K7IP1 IRF9 TRAF6 TNF EEA1 TRAF2 FADD PMC7872968__F8 RIG-I signaling pathway TBK1 NLRX1 MAVS TRADD IRF3 TRAF3 TRAF6 TRAF2 FADD PMC8716783__F2 Long Noncoding RNA H19: A Novel Therapeutic Target Emerging in Oncology Via Regulating Oncogenic Signaling Pathways APC MTOR CTNNB1 FADD PMC7872968__F5 HIF-1 signaling pathway and (B) relaxin signaling pathway in lungs STAT3 MMP2 HIF1A MMP9 MTOR EIF4E PMC7872968__F6 IL-17 signaling pathway IL17RC IL17RA RALB ARF6 TRAF6 PMC7188829__F5 DEGs enriched in TNF (A), PI3K-AKT (B) signaling pathway during A BAD TRADD FAR1 BCR EBP MEI1 CD19 MDM2 RAC1 FADD PMC4239617__F10 Proposed mechanism/model for the rationale of treatment with a combination regimen of GCs and IFNA in HBV-infected cell STAT1 GC MAT1A PMC4222351__F4 P-21 activated kinase (PAK)1 in canonical and non-canonical NFKB signalling CDC42 PAK1 TLR4 RELA RELB RAC1 PMC8470495__F1 Promising Biomarkers of Radiation-Induced Lung Injury: A Review HMGB1 IGF1 VTN IGFBP7 MTOR CTNNB1 PMC6955834__F4 Intermittent fasting‐mediated pathways that induce adult hippocampal neurogenesis BDNF NOTCH1 HES5 PMC10297110__F5 The effects of inhibiting TGFB signaling pathways on hCECs in vitro ECD SMAD2 RHO MTOR PMC6210224__F11 IFN-λ3 rescued the RIG-I signaling pathway STAT1 IF1IB1 RIGI MAVS TRIM25 STAT2 IFNL3 IFIT3 OASL IRF3 IRF7 PMC6199328__F8 TEdeff-induced immunotherapy resistance STAT3 STAT1 CASP8 JAK1 FADD PMC8818883__F4 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis ITCH TNF TRAF2 FADD PMC3745214__F1 Targeting TGFB signaling in cancer TF SMAD2 SMAD6 SMAD4 RHO TRAF6 PMC8818883__F5 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis MAK MAL DERA ELL ARC PMC8770568__F1 Therapeutic targets identified in clinical and pre-clinical studies for ESR1 mutant breast cancer CDK6 IGF1 IGF1R MTOR CDK4 PMC8818883__F6 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis CD40 CPO IRF3 LBP PMC8818883__F7 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis HEL-S-99n CD36 TLR4 VAMP3 STX7 CD14 MARCO TUBB MPO PMC3745214__F4 Targeting TGFB signaling in cancer TF SMAD2 SMAD4 PMC8764032__F4 Proximity ligation strategy for the genomic reconstruction of microbial communities associated with the ectoparasite Caligus rogercresseyi IVD HMGCL ACADS DBT HSD17B10 DLD MCCC1 ACAD8 PMC314152__F7 LMP1-induced canonical and noncanonical NFKB activation RELB IRAK1 REL CXCR4 TRAF2 PMC5697452__F6 Mechanism by which MMP-9 regulates formation of focal adhesion junctions CD44 EGFR SRC PMC11640812__F2 Crosstalk relationships between signaling pathways MTOR JAK1 PMC11523861__F1 Dietary Sources of Tryptophan and Main Pathways of Tryptophan Degradation (a) Tryptophan, an essential amino acid, is commonly acquired from dietary sources such as turkey, eggs, cheese, tofu, seeds, and fish HEL-S-90n KYNU KMO AANAT HAAO ASMT AFMID PMC11523861__F2 Tryptophan Sample Collection, Detection Methods, and Biological Functions Samples for tryptophan detection are typically obtained from blood specimens, cancer tissues, and cancer cell lines CD40 BCR PMC6196929__F1 Possible signaling mechanisms of SERM actions in neurocognition and neuroprotection EGF IGF1 BDNF CTNNB1 PMC2896874__F11 Schematic overview of MAPK-regulated processes that are thought to couple light to the SCN clock during the early night PER1 JUNB EIF4E PMC9677642__F7 Identification of crucial genes and metabolites regulating the eggshell brownness in chicken SLC25A38 HMBS CPOX ABCG2 FECH ABCB10 UROD UROS PMC9530249__F2 NFKB and its crosstalk with endoplasmic reticulum stress in atherosclerosis NLRP3 CD36 TLR4 IL33 PMC9530249__F3 NFKB and its crosstalk with endoplasmic reticulum stress in atherosclerosis TRIM13 MAVS NLRP3 GSK3B NOD1 ATF4 EIF2A XBP1 NOX4 TRAF2 UNK IL1B PMC3855043__F5 IPA pathways of ChIP-Seq-based NSRF target genes in ESC GRB2 TBP PMC6438767__F7 Cannabinoid-1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure via Sirt1/mTORC2 and AMPK Signaling RICTOR FOXO1 SIRT1 PMC6600375__F6 TGFB mediates metastasis ANGPTL4 MMP10 MMP21 PMC4034110__F1 Mitochondrial and metabolic checkpoints of T-cell activation and apoptosis signals CAD PLCG2 PMC6932957__F7 Hypothesized pathway of mitochondrial apoptosis activation induced by HEV infection VIP NOX4 IL1B PMC5620223__F7 EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer EGF EGFR SMAD2 SMAD4 NODAL PMC4134689__F2 Therapeutic strategies to target mutant NRAS: Direct targeting strategies include inhibition of RAS transcription by RNA interference and blockade of posttranslational modification by farnesyltransferase inhibitors CDKN2A NRAS PTEN MTOR CDK4 PMC6600375__F1 TGFB/SMAD and non-SMAD signaling CDC42 TRAF4 SMURF1 SMAD2 SMAD4 ARHA GRB2 MTOR SMURF2 PMC11523861__F3 Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer KYNU KMO AHR SLC7A5 AFMID PMC6600375__F2 TGF-Beta-induced growth inhibition and apoptosis SMAD2 SMAD4 TRAF6 BIK PMC11523861__F5 Molecular Mechanisms of Tryptophan Metabolism in Digestive System Cancers (a) Tryptophan metabolism plays dual roles in digestive system cancers, promoting or suppressing tumor growth IFNG CDC20 AHR SLC7A5 MYC MPO PMC9694461__F1 New Therapeutic Trend: Natural Medicine for Ameliorating Ischemic Stroke via PI3K/Akt Signaling Pathway FAS AGA MTOR PLLP TNF FADD PMC9305908__F1 17Beta-Estradiol Concentration and Direct B2-Adrenoceptor Inhibition Determine Estrogen-Mediated Reversal of Adrenergic Immunosuppression BAX BOK PMC6102727__F7 Schematic overview of LATS1/YAP/RHAMM pathway and the regulatory effects of LATS1 in the LATS1/YAP/RHAMM pathway LATS1 KLF5 MTOR PMC6869463__F6 Schematic showing the role of CNPase/Notch signalling pathway in modulating EMT and fibrosis SMAD2 SMAD4 PMC2835842__F1 HSV-1-mediated antagonism of TLR-dependent, anti-viral pathways TLR3 TLR9 RNASEL IRF3 TRAF6 MYD88 PMC5226503__F4 Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma RPE TKTL2 HEL-S-304 ALDOB ENO2 HEL-S-68p HK2 PCCA SHMT1 HEL-S-51e PMC9696821__F6 Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics HEL-S-68p HEL-S-87p HEL-S-30 PMC5374583__F7 Survival and proliferative effects of AOF extract on RSC96 Schwann cell BAD IGF1 IGF1R CCND1 PMC2693384__F2 Regulation of Vascular Permeability by Sphingosine 1-Phosphate GIT2 CAD PAK1 APC RAC1 PMC3038250__F4 PI3K/Akt and RAS/BRaf/MEK pathways are frequently altered in melanoma AKT3 BRAF PTEN PMC7258707__F7 Potentiating immune response by activating TLR signaling pathways.With the exception of TLR3, all TLRs activate MyD88 dependent pathway which leads to NFKB mediated proinflammatory cytokine upregulation TBK1 TIRAP TLR3 TLR4 TLR9 CD14 IRF3 TLR7 TRAF6 MYD88 PMC9658955__F8 LMNA Reduced Acquired Resistance to Erlotinib in NSCLC by Reversing the Epithelial–Mesenchymal Transition via the FGFR/MAPK/c-fos Signaling Pathway EGF EGFR PMC8540886__F2 Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment SRGN CD80 FAS PRF1 APC LAG3 PMC9179421__F1 Cancer-Induced Metabolic Rewiring of Tumor Endothelial Cells TEC FAS GLS HK2 CPT1A PMC12152662__F1 Regulation mechanism of PD-L1 in cellMultiple transcription factors directly modulate PD-L1 expression through distinct mechanisms STAT3 BRD4 EGF HGF EGFR BRAF IRF1 PTEN HIF1A MTOR MYC IFNG STAT1 PMC12152662__F2 PD-L1 in the ALK oncogenic signaling pathway in NSCLCThe EML4-ALK fusion protein enhances PD-L1 expression by activating downstream signaling pathways, including ERK, AKT, STAT3, and HIF-1A (24) ATF3 MTOR KRAS PMC6035094__F3 An overview of the cannabinoid type 2 (CB2) receptor system and its therapeutic potential TBK1 TIRAP TICAM2 TANK IRF3 TRAF3 TNF TRAF6 MYD88 RARA TLR1 MAP3K7IP1 MAP2K6 TLR4 PMC9572342__F10 Fermentation Extract of Naringenin Increases the Expression of Estrogenic Receptor B and Modulates Genes Related to the p53 Signalling Pathway, miR-200c and miR-141 in Human Colon Cancer Cells Exposed to BPA TP73 BAX RPRM APAF1 PMC3737462__F2 Accumulation of monocytes/macrophages in adipose tissue and liver, and activation in the tissues KLF4 TLR4 IL1B PMC3442742__F1 NGF signaling pathways in mediating neurotrophic and nociceptor effects.Notes: NGF signals through the high-affinity TrkA and low p75NTR receptors NGF TRPV1 PMC2435278__F2 The Aedes aegypti Toll Pathway Controls Dengue Virus Infection TH TUB FADD MYD88 PMC6047740__F2 Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? ROR1 ROR2 ARHA RAC1 DAAM1 CTNNB1 PMC3735683__F3 From Genetics of Inflammatory Bowel Disease Towards Mechanistic Insights NCF2 NCF4 DUOX2 PMC6047740__F5 Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? CEP164 APC NEK2 GSK3B PLK1 CTNNB1 CDK5RAP2 PMC9462662__F2 Relationship of alpha-synuclein to mitochondrial dynamics and quality control PINK1 SNAP29 OPTN PMC5644195__F13 Agents that affect the Hippo pathway (Nat Rev Cancer LATS1 LATS2 TRIO DICER1 AMOT APC PTEN SCRIB RHO PMC6722120__F4 BC subtype-specific EV protein kinase networks ARAF RAF1 EPHA2 IKBKB FGFR4 GSK3B PAK4 SI FGFR3 MAP2K2 MTOR MAPK3 PMC6682198__F8 Schematic mechanism of apoptosis in ovarian cancer and some current targeted molecular therapeutic approaches NAIP FAS MTOR GATA4 TNF PMC9116921__F2 Ongoing Clinical Trials in Aging-Related Tissue Fibrosis and New Findings Related to AhR Pathways SIRT3 SMAD2 GSK3B SMAD4 AHR SIRT1 CTNNB1 TGFBR1 PMC4457513__F2 Reelin-Disabled-1 signaling in neuronal migration: Splicing takes the stage CDC42 CDH2 CRK DAB1 MAP1B VLDLR CUL5 LIMK1 GSK3B PMC6193731__F3 ROS accumulation induced by fungicidal drugs CMA1 HEL-S-11 HEL-S-44 PMC8792817__F1 Metabolism and Health Impacts of Dietary Sugars KHK XYLB PMC3524319__F6 Construction of the regulatory networks associated with the selected genes using IPA® database SOCS1 IL15 CD40 CXCR3 FAS CD72 IFIT1 CCR2 IL2RG IFIT3 TRAFD1 CREM IFIT2 CTSZ IFI35 SOCS3 SMPD1 CCL2 IL15RA DECR1 PLEK IFNG LITAF MHC2TA CASP4 PSMB10 MX2 PSME2 OAS2 LCP2 PIM1 SERPING1 SERPINA1 IRF1 IRF7 FCGR1A GBP1 IL10RA IL6 IRF8 TNF CXCL10 RELA FBP1 FGL2 S100A9 PMC3138766__F6 JAK2 V617F-Dependent Upregulation of PU.1 Expression in the Peripheral Blood of Myeloproliferative Neoplasm Patients STAT3 STAT5B SOCS3 PMC5154753__F2 Pathways activated following binding of the TSLP cytokine to its receptor complex TSLP JAK1 PMC1774275__F5 Mitogenic signals are transduced by Ras which inhibits the retinoblastoma (Rb) protein allowing E2F and Myc to promote cell cycle progression BAX BAD FAS PTEN MDM2 MYC PMC1774275__F4 The chromosomal instability (CIN) pathway (see text for details) APC LEF1 PMC1774275__F1 Simplified diagram of the Wnt/APC pathway APC CCND1 CTNNB1 PMC6240956__F3 Foamy phagocyte polarization follows a triphasic pattern IFNG IL10 IL16 ARG1 IL6 IL1B PMC4612627__F3 Simplified model of a cell signaling process highlighting the flow from signals generated externally by epidermal growth factor (EGF) to the activation or repression of transcription EGF EGFR PTEN MYC PMC1774275__F2 Intrinsic, or mitochondrial, pathway (after Danial and Korsmeyer) BAX BAD DIABLO PMC1375233__F5 Two signaling pathways of TLR in myeloid DCs MAP3K7IP1 TLR3 TLR4 MAL CD14 IRAK1 IRF3 TRAF6 IRAK4 MYD88 PMC6775198__F1 Role of Wnt Proteins in T cells FOXP3 PMC1375233__F2 Association between human TLRs and adaptors determine each TLR-specific signaling pathway TLR3 TIRAP TLR4 MAL TLR9 TLR5 IRF3 TLR7 ATF2 TRAF6 MYD88 PMC3978635__F1 mTOR pathway and actions TSC2 TSC1 PTEN MTOR PMC6775198__F2 Immune exclusion through the Wnt/beta-catenin pathway CCL4 IL6 FOXP3 IL1B CTNNB1 PMC3978635__F2 mTOR-dependent pathways and inhibitors TSC2 TSC1 PTEN MTOR PMC4547497__F2 Signaling pathways associated with CLRs on dendritic cells SYK BCL10 PDC CARD9 PMC2659592__F7 Lysophosphatidic Acid Induces Interleukin-13 (IL-13) Receptor A2 Expression and Inhibits IL-13 Signaling in Primary Human Bronchial Epithelial Cells LPA IL13RA1 PC IL13RA2 PMC6775198__F3 Effect of WNT signaling on cancer immunosurveillance TF BATF3 CCL4 FOXP3 PMC5857409__F4 Proposed potential therapeutic targets in Erythroleukemia CHP2 ALK EPOR PMC2651172__F7 Possible site for alcohol-induced inhibition of muscle protein synthesis RHEB TSC2 TSC1 MTOR EIF4E PMC8457986__F3 Positive Role and Mechanism of Herbal Medicine in Parkinson's Disease BAD NLRP3 KEAP1 ATF4 PMC4048572__F8 Exercise-Induced Skeletal Muscle Remodeling and Metabolic Adaptation: Redox Signaling and Role of Autophagy HDAC1 IGF1 ATG12 ULK1 FOXO3A PTEN ATG5 HDAC2 SIRT1 PMC8286568__F5 Bacterial alginate metabolism: an important pathway for bioconversion of brown algae IPP PDC APP PMC7442787__F7 Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused PPP4R2 SUFU PTCH1 MB PMC7652989__F1 Sphingolipid biosynthetic pathway in plants and the inhibition of this pathway by FB1 SPHK1 HEL-S-5 SPP1 PMC4746004__F4 Collateral Lethality: A new therapeutic strategy in oncology HEL107 RPE PMC4383600__F2 Interplay between multiple factors in the transforming growth factorB (TGFB) signalling pathway and the control of muscle mass BAMBI GDF5 SMAD1 GDF8 DKFZp781O1323 SMAD2 SMAD4 SKI PMC2705117__F3 Role of peroxisome-proliferator-activated receptor B/D (PPARB/D) in gastrointestinal tract function and disease ANGPTL4 COX2 RXRA APC CCND1 PMC4071223__F7 Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis TLR1 SMURF1 MAL ARHA MYD88 PMC10854888__F1 HSP in biochemical functions of cells BAX BAD HEL-S-62p C2 TLR4 ATG14 PMC9413412__F1 Crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer POR MAPK14 SLC3A2 STEAP3 GPX4 LPCAT3 DPP4 FACL4 SLC7A11 PMC10758458__F2 Advances in the role of microRNAs associated with the PI3K/AKT signaling pathway in lung cancer ABCC1 KEAP1 ABCC5 ABCG2 ABCC2 PMC10758458__F3 Advances in the role of microRNAs associated with the PI3K/AKT signaling pathway in lung cancer PHLPP1 FOXO1 PHLPP2 PTEN RAC1 CELF2 ID3 PMC9380331__F7 Structure and character analysis of cotton response regulator genes family reveals that GhRR7 responses to draught stress PRR9 ELF4 PRR12 HK3 COPE HK2 CRY2 ELF3 CAT56 PMC4189230__F1 Process and mechanisms of blood vessel formation SMAD2 PDGFRA SRC PMC3143902__F1 Inhibition of myostatin (MSTN) and activin signalling by the soluble activin type IIB receptor (ActRIB) ALK SMAD2 PMC10758458__F1 Advances in the role of microRNAs associated with the PI3K/AKT signaling pathway in lung cancer TSC2 BAD TSC1 EGFR PTEN MDM2 GRB2 MTOR EIF4E PMC6436762__F9 Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K CDC2 FOXM1 ECT2 PLK1 PMC3964957__F6 Pathway diagram customization is available via the web interface, and lets the user control many aspects of the pathway diagram FER PROC PMC11029991__F7 Bioinformatics-based discovery of biomarkers and immunoinflammatory targets in children with cerebral palsy: An observational study SLC3A2 IRF9 JAK3 GSK3B LRP5 LRP6 PTEN FLCN MTOR IL6 RHO SKP2 DEPTOR EIF4E RHEB MLST8 GFAP RICTOR GRB10 IL2 GRB2 JAK1 RNF152 TYK2 PMC5918238__F3 Non-bilayer phospholipids in mitochondrial structure and function PGS1 PGP PSD2 PMC6362586__F4 Associative gene network describing interactions between three central genes/proteins of the extrinsic apoptotic signaling pathway biological process SNAI2 FAS TIMP3 TGFB1 ASL MCL1 TNFSF6 PTEN TNF ENSA NGF SIL1 FYN BAG3 BRCA1 BMP4 RNF34 EN1 BCL2 TRAF1 IL7 DIABLO PMC6436762__F1 Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K RHEB TSC2 BAD INSR MCL1 PTEN IRS1 EIF4E PMC8809485__F2 Gaucher Disease: Basic and Translational Science Needs for More Complete Therapy and Management RHEB RIPK3 TBK1 NLRP3 TFEB RIPK1 IL1B PMC11504183__F1 BMP concentration on fate of ectodermal cells to induce epidermal, placodal, neural crest, and neural derivatives SIX1 SHH PAX6 HES1 PMC11504183__F2 BMP signalling pathway and modulators during development of pre-placodal ectoderm SMAD1 DKFZp781O1323 TWSG1 BMP4 BMP2 SMAD4 BMP7 PMC9199383__F2 Neutrophils in COVID-19: Not Innocent Bystanders TBK1 CGAS STAT2 IRF9 TLR9 IRF3 TRAF3 RIF1 TRAF6 MYD88 STAT1 NLRP3 IFNAR2 IFNAR1 TLR8 TLR7 JAK1 TYK2 ACE2 PMC2950451__F3 Metabolic flux distribution through branching areas of the central metabolism of MG1655 and ECOM4LA cell lines MAL GIP CIT PMC7405837__F8 DEGs in RPE cells of the cholesterol synthesis pathway HMGCS1 HMGCR MSMO1 SQLE SC5D PMVK DHCR24 MVD DHCR7 FDPS FDFT1 MVK PMC5876234__F10 Lico A-mediated Nrf2 signaling pathway protects APAP-induced ALF via inhibition of mitochondrial dysfunction and apoptosis KEAP1 GCLM GCLC MAF APP PMC3742697__F8 Proposed model of Cr(VI)-induced carcinogenesis LEP GSK3B MTOR CTNNB1 PMC7868402__F6 LncRNA H19 regulates the gene pathway of osteogenic differentiation through the lncRNA-miRNA-mRNA network (; ; ; ; ) HDAC5 RUNX2 PMC7405837__F6 DEGs in RPE cells of the sugar metabolizing pathway PHKA1 PYGM GYS1 PGM2 AGL PMC7405837__F7 DEGs in RPE cells of the glycerophospholipid metabolism pathway PTDSS2 CDS2 PCYT1B HMFN0839 BTD GPAT4 CHPT1 GPAT2 AGPAT3 PNPLA2 PCYT2 PID1 GPD1 PLA2G2A LPA ACACB GPAM LPCAT4 CDS1 LPIN1 PC CEPT1 PMC7405837__F4 DEGs in RPE cells of ATP-producing pathways ACO2 IDH3B AIP PDK3 PDK2 SDHD SDHA PDK4 SUCLA2 OGDH NDUFA3 ZNF183 PDHA2 COX11 PMC7405837__F2 DEGs in RPE cells of the circadian rhythm pathway PER3 RORC MYF6 ETV6 PER2 NR1D1 CRY2 CRY1 NR1D2 PRKAB2 BHLHE41 PMC7868402__F3 Regulatory effect of methylation levels of bone metabolism-related genes on bone formation (; ; ; ; ; ; ; ; ) SOST BMP2 RUNX2 PMC7868402__F4 Illustration of SIRT1 signaling pathway in bone remodeling (; ; ; ; ; ; ) SOX2 RUNX2 SIRT1 PMC5391975__F3 Signaling networks activating the canonical RAF-MEK-ERK signaling pathway and that have been involved in SCLC metastasis (see text) CXCL12 HGF CXCR4 FGF2 PMC4970276__F8 Model deciphers molecular mechanisms by which PRMT5/p44 controls cell growth ERBB3 GLIPR1 BTG2 ERBB2 PMC3679380__F5 Extranuclear and nontranscriptional effects of RA and vitamin A RARA SRC PMC7211317__F8 Schematic model for the ability of RTR-1 to induce cell cycle arrest and apoptosis STAT3 BAX ATM PMC7564532__F4 Hypothalamus-pituitary-gonad (HPG) axis in vertebrates and related molecular pathways GAL TAC3 GNRHR PRL NPY AgRP FSHR LHCGR PMC9179555__F4 Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease TSC2 MTOR PMC2992886__F3 Genes associated with autoimmunity regulate the CD40/NFKB signaling pathway CD40 TRAF1 TRAF2 PMC4874354__F8 Glycolysis HEL-S-162eP HP PMC8176995__F3 Can Some Anticancer Treatments Preserve the Ovarian Reserve? RPS6 BMP4 LIF KIT PTEN PMC7170511__F16 Models for RHAMM-regulated motogenic signaling in keratinocytes and temporal-spatial coordination of keratinocyte and fibroblast migration in excisional wounds CD44 EGFR MMP9 PMC3826850__F1 The Drosophila Toll and Imd pathways DEAF1 REL FADD PMC2491602__F6 TNFA signaling pathway TRADD TRAF2 FADD PMC6895844__F6 Network and pathway analysis of shared networks between AD and T2D RPS15A EED SIRT7 GABARAPL1 COPS5 SMC3 MYC HUWE1 SNRPE CSNK2A1 MDM2 TARDBP RPL31 NCK1 SENP6 SET BCLAF1 CAND1 EIF3E CDKN1A BRCA1 PSMC6 CALM1 RPL9 GABARAPL2 HLA-B VCAM1 GRB2 NCL UBE3A TNFAIP3 MAP1LC3A EGFR WASL IFIT1 EIF3L CTNNB1 LY96 LSM3 DDX1 RPL17 PAN2 APP EIF4A2 ISG15 CDC5L HEL2 YWHAG CD81 SNRPG ARRB2 ITGA4 ERBB4 BLNK CBX3 PARP1 DEK ARGLU1 ELAVL1 RYBP TNFSF10 YWHAZ FADD PMC6895844__F7 Network and pathway analysis of shared networks between advanced AD and T2D OTUD4 SYK SIRT7 RAF1 COPS5 GSK3B PIK3R1 MYC TRAF6 MAPK8 FGFR2 MAPK14 AKAP11 HEL-S-1 CACYBP SMC4 EIF2AK2 TARDBP MORF4L2 SFPQ SNCA BCLAF1 CAND1 SMARCA5 DDB1 BRCA1 RXRA CALM1 EN1 PRKAB1 SNW1 HLA-B VCAM1 GRB2 PPP1CC EGFR NUDT21 PPP2CA RYK VCP CTNNB1 CLASP2 UBR5 SUMO2 USP15 YWHAQ NR3A2 APP TBL1XR1 HEL2 YWHAG HDAC6 HSP90AB1 CDC2 MOV10 ITGA4 SOCS4 SOX2 PPP2R1A CCNC RAC1 MED1 NUP160 RPA1 HDAC1 ELAVL1 ERBB2 CDC37 LYN PS1TP5BP1 YWHAZ KAT2A TIA1 PMC6669704__F1 Prostaglandin biosynthetic pathway COX1 PTGIS COX2 C2 PMC5788649__F1 Gene master regulators of papillary and anaplastic thyroid cancers PIK3CA PDCD1 GADD45G PIK3R2 PPP3CA MYC PPP3CC MAPK3 DCP2 CCNJ MAPK1 CASP9 HRAS DDB2 TCF7L2 CDKN1A DFFA BCL2 BAK1 CASP10 PRKAR1B RET BAD TNFRSF1A AKT3 BRAF CAPN10 MAP3K14 IKBKG CTNNB1 TPR CASP6 TPM3 CHUK BIRC3 BAX TFG DFFB KRAS CCDC6 POLK NFKB1 IKBKB RELA CASP3 NFKBIA MAP2K1 MAP2K2 BIRC2 TRAF2 LEF1 PMC7016469__F6 Cyclooxygenase 2 (COX2) promotes ovarian cancer cell proliferation and invasion via the prostaglandin E2 (PGE2)/ nuclear factor-kappa B (NFKB) signaling pathway STAT3 PTGER2 COX2 MMP2 MMP9 PMC4316382__F2A BMolecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells MMP10 ECT2 SOX2 SMO PMC1828403__F1 Representation of TLR4-signaling through the MyD88-dependent and MyD88-independent pathways TBK1 STAT2 IFNAR2 TLR4 IRF9 IFNAR1 IRAK1 IRF3 JAK1 TRAF6 TYK2 MYD88 PMC4742202__F5 Genome and transcriptome delineation of two major oncogenic pathways governing invasive ductal breast cancer development PIK3CA CBFB ERBB2 MUC4 GATA3 PMC2947987__F3 Genome of a Pathogenic Rhodococcus: Cooptive Virulence Underpinned by Key Gene Acquisitions RP1 MSRA CLPS LBP PMC11604654__F4 Two signaling pathways that Fish oil and Forskolin involved23–25 BMP15 BMP6 STAR INSR COX2 LDLR FSHR PMC12174911__F1 Cross-regulation of ferroptosis and immunogenic cell death in tumor microenvironment HMGB1 GPX4 MPO PMC12174911__F2 Comprehensive schematic diagram of cross-regulation of ferroptosis and immunogenic cell death STAT1 FACL4 SLC7A11 PMC2663527__F1 The formation of leukotrienes (LTs) through the 5-lipoxygenase pathway of arachidonic acid metabolism, and the effects of LT inhibitors in different contexts CRP LTB LTA PMC9702548__F7 The effects of HFPGE on the immune response in RAW 264.7 cells CXCL10 TRAF6 TNF PMC8431791__F2 Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases CDC42 RHO PMC8017335__F2 IL-1 family cytokines regulate NK-cell responses IL33 STAT4 ATF2 PMC8017335__F3 Type 2 cytokines show diverse effect of NK cells activation STAT3 STAT4 PMC3666258__F5 Diagram of norrin as a multifunctional ligand for three receptors/binding proteins BMP4 BMP2 PMC7728369__F7 Proposed model illustrating mechanisms of USP39 regulating the proliferation, apoptosis and metastasis of non-small lung cancer cells via regulating the p53 pathway MMP2 MMP9 PMC10534927__F3 Could Natural Products Help in the Control of Obesity? Current Insights and Future Perspectives CRP TBK1 CGAS CS VCAM1 PMC9063567__F1 Altered Cholesterol Homeostasis in Huntington’s Disease DHCR24 CH25H DHCR7 CYP46A1 CYP27A1 PMC4316382__F1A BMolecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells BOC SUFU SMO GAS1 PMC9360899__F1 PI3K/AKT signaling pathway in gallbladder carcinoma SP1 EGFR DMBT1 PTEN PMC10871146__F1 Hydrogen maintains an anaerobic environment in the intestine and reduces oxidative damage via selective antioxidant effects ATF4 EIF2A XBP1 MPO PMC4409470__F2 Nutrients, Foods, and Colorectal Cancer Prevention NR1i1 BAX COX2 HEL-S-11 PTH INS PMC9360899__F2 PI3K/AKT signaling pathway in gallbladder carcinoma BAX FAS PTEN PMC5944465__F3 Quantum dots in cytotoxicity NLRP3 TRAF6 APAF1 MYD88 PMC2494582__F1 Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus AQP2 GC RHO PMC5209388__F1 Tetrahydrofolate (THF) synthesis, C1 metabolism, and triacylglycerol (TAG) biosynthesis in plant cells DHFR PC PAH PMC6557086__F6 L-Norvaline, a new therapeutic agent against Alzheimer’s disease NGF GDNF SPHK2 SYP MTOR RET PMC10649278__F6 Diagram of IL-17 signaling pathway TH TRADD FRY COX2 MAK FADD PMC4714141__F4 Pathway of miR-7 in hepatocellular carcinoma HOXD10 CCNE1 EGFR MTOR PMC9010204__F3 Targeting Oxidative Stress and Endothelial Dysfunction Using Tanshinone IIA for the Treatment of Tissue Inflammation and Fibrosis STAT3 TLR4 SMAD2 SMAD4 MTOR NOX4 PMC10623083__F7 CFH knockdown suppresses the stemness of breast cancer cells through regulation of the EPB41L3/MAPK axis CD44 EPCAM CD24 NHS SOX2 CFH EPB41L3 PMC5833577__F4 Necroptosis signaling by TNFR1 stimulation via TNF RIPK3 TRADD MLKL RIPK1 TNF FADD PMC5135332__F6 Reconstruction of purine biosynthetic pathway in C HEL-S-70p PFAS ADSL PMC5833577__F3 Signaling pathways of neutrophil necroptosis RIPK3 TRADD MLKL RIPK1 TNF FADD PMC11839971__F11 circ0066187 promotes pulmonary fibrogenesis through targeting STAT3-mediated metabolism signal pathway STAT3 COL6A1 DPP4 CDK2 CCND1 FGF2 PMC2212850__F2 Major signaling pathways for type I IFN gene transcription TBK1 TLR3 TLR4 TLR9 IRF3 TLR7 TRAF6 TNF MYD88 PMC4714141__F1 Pathway of microRNA-7 in gastric cancer EGFR GC IGF1R MTOR PMC4714141__F3 Pathway of microRNA-7 in colorectal cancer BAX EGFR MMP2 YY1 MMP9 PAX6 CCND1 PMC8198407__F3 Interaction between Metformin, Folate and Vitamin B12 and the Potential Impact on Fetal Growth and Long-Term Metabolic Health in Diabetic Pregnancies MTHFD1 DHFR MTRR PMC9312970__F9 Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway GSDMD GCLM TLR4 PMC4791278__F3 Ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells MDM4 BRCA1 CKS2 ATM PMC9535683__F3 Cytoskeletal dysregulation and neurodegenerative disease: Formation, monitoring, and inhibition of cofilin-actin rods CDC42 VASP SGK1 SSH1 RANBP9 ARHA RAC1 PMC8435905__F1 Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features DBP EHHADH LAT HSD3B7 SLC27A5 COA1 SI CYP46A1 CYP7B1 CYP27A1 AMACR LBP H1-3 PMC8435905__F3 Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features CYP2R1 LAT CYP7A1 HSD3B7 CYP46A1 CYP7B1 CYP3A4 CYP27A1 PMC7218026__F6 Schematic presentation of the ACLY PIP2 binding region and the novel Lyn/Src-dependent tyrosine phosphorylation sites ACLY LYN SRC PMC4177877__F1 Breast Cancer Stem Cells: Multiple Capacities in Tumor Metastasis GSK3B SMO CTNNB1 PMC4177877__F3 Breast Cancer Stem Cells: Multiple Capacities in Tumor Metastasis SIRPA CD47 PMC7720970__F1 Revisiting Hormonal Control of Vascular Injury and Repair PTCH2 PTCH1 SMO PMC5853294__F1 Metabolic pathways for TAG biosynthesis in green algae FAS PC PMC8403061__F6 C-Type Natriuretic Peptide Plays an Anti-Inflammatory Role in Rat Epididymitis Induced by UPEC COIL CNP IL1B PMC4391155__F5 The PVT1 functions NOP2 MYC PMC4487016__F2 Amino acid sensing in yeast and mammals at the vacuole or lysosome RHEB WDR59 SH3BP4 NPR2 NPRC SLC38A9 WDR24 PMC11898294__F6 Enhanced CTL responses in TNBC via MUC1 mRNA nanovaccine and anti-CTLA-4 therapy NPS MUC1 CTLA4 PMC4487016__F3 Molecular architecture of the SEA complex WDR59 NPR2 DEPDC5 NPRC WDR24 PMC11898294__F7 CD8+ T cell-enhancing nanovaccines for cancer treatment IRF3 IRF7 TNF PMC7185212__F2 CD8 T cell linear differentiation model IFNG BATF FOXO1 APC CCR7 IL2 RUNX3 PMC6047740__F6 Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? RPGRIP1 FOXJ1 APC CELSR2 NODAL RHO WDPCP CELSR3 PITX2 PMC11898294__F3 Types and mechanism of nanovaccine adjuvants CXCL9 IFNG CGAS TNF PMC4531834__F2 Extrinsic cell death pathway is typically triggered by members of the tumor necrosis factor (TNF) family of death receptor ligands, comprising TNF itself, Fas ligand, and TNF-related apoptosis-inducing ligand (TRAIL) FAS TRADD MLKL TAB3 TNF CYLD TRAF2 FADD PMC6888741__F2 DUB family members BAP1 USP11 USP9X USP9Y USP14 USP33 USP15 USP4 USP2 USP18 USP1 USP20 CYLD USP26 USP16 USP6 PMC6888741__F3 Hippo signaling pathway LATS1 LATS2 ANKRD1 RHO NF2 AREG PMC6888741__F4 DUBs and their role in Hippo signaling LATS1 LATS2 YOD1 ITCH AMOT USP11 USP21 USP9X OTUD1 VGLL4 OTUB2 PMC11898294__F1 T-cell activation, immune suppression, and therapeutic strategies in the TME HEL-S-92n HMOX1 CD80 FAS CD27 TNLG8A PMC8918930__F10 Chinese Herbal Extracts Exert Neuroprotective Effect in Alzheimer’s Disease Mouse Through the Dopaminergic Synapse/Apoptosis Signaling Pathway TH REL PMC5127022__F3 A diagram of host factors involved in MeV inducible stress granule formation and autophagy BAX MAVS ATG12 IRGM GOPC EIF2A TIA1 ELF3 PMC4844344__F12 SIG5 expression control in the light-signaling pathway regulating the expression of the chloroplast genes psbD and psbA for the photoreaction center II core proteins D1 and D2 in response to light intensity and quality RFWD2 CRY2 CRY1 PMC4695848__F1 Functional role of deubiquitinating enzymes in autophagy USP35 USP30 USP36 RALB USP33 USP15 USP20 PMC6288913__F1 HCV life cycle and involved Rab proteins EGF CD81 RAB27A EPHA2 RAB7A EGFR RAB11A RAB32 LDLR RAB3D RAB13 RAB18 RAB8B RAB1B RAB23 CLDN1 PMC8649520__F1 Bioinformatic analysis of transcriptome data sets for aortae obtained from aged ApoE −/− mice fed a high‐fat diet revealed 50 overlapping genes that are enriched for ER stress‐ and UPR‐related pathways BAX VAPB TMEM33 APOE PIK3R1 BOK HEL-S-89n XBP1 EIF2AK2 PMC8649520__F7 Schematic summary detailing the distinct UPR pathways regulated by hypercholesterolemia and aging within aortic and lung tissues in a murine model of atherosclerosis APOE ELF2 ATF4 PMC8651359__F7 Exploring the Therapeutic Mechanisms of Huzhang–Shanzha Herb Pair against Coronary Heart Disease by Network Pharmacology and Molecular Docking TES TRO SRI KY tmp_locus_29 MAL FEV PMC4979440__F8 Role of EtOH-mediated cytotoxicity and neuroinflammation in context to HAND via cPLA2signaling in human astrocytes CYP2E1 COX2 CXCL8 IL1B PMC2651582__F1 Metabolic reprogramming in tumor cells HK2 FASN CPT1A PMC2788154__F1 Signaling pathways that lead from activated KIT and aggregated FcERI to mast cell responses STAT3 SYK STAT1 BTK LAT KIT VAV1 LYN GRB2 SRC LAT2 GAB2 PMC3417476__F1 Cyclic AMP-mediated induction of Treg cells and suppression of effector T cells CSK FOXP3 LCK PMC5516276__F4 Genes uniquely modulated in Fam13a−/− mice are involved in carbohydrate, lipid metabolism, and molecular transport network TES CSF1 WNT3A MRPL12 CD177 CTSK TMPRSS4 DAP3 PECAM1 MRPL9 ANTXR1 SLC30A7 MEN1 MEIS1 ZNF521 ITGB5 PMC3163944__F7 Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice MAX EGF JUND FAS PTPN5 EGFR CD14 NTRK2 ATF2 TNF DUSP2 FLNA MEF2C RASA2 SHOC2 NTRK1 DDIT3 PRKX MAP2K2 GRB2 GAB2 PMC9499665__F1 Could BMPs Therapy Be Improved if BMPs Were Used in Composition Acting during Bone Formation in Endochondral Ossification? MAP3K7IP1 SP7 SMAD4 DLX5 HOXC8 RUNX2 PMC5516276__F3 Genes uniquely modulated in Hhip+/− mice are involved in the connective tissue development and function network NPPC MAPK1 KCNE2 HSD11B1 CHAD TACSTD2 ALOX15B EMP1 ACAN CNPY4 GIPC2 PCSK5 FGFR4 OSBPL3 BHLHE41 NPPB CLDN5 EMCN NPRC PMC8524061__F5 Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy FYN FGF21 SMAD2 GSK3B ATF4 MDM2 SIRT1 PMC8524061__F1 Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy DAP GRB2 SHE SRC PMC4397736__F1 Metabolic loops increase pathway multiplicity GLCE PIG59 ENO2 PGM2 HFE PMC4397736__F2 Comparison between simulations and MFA experiments MALL CS CIT PMC7564852__F3 Schematic depicting the molecular mechanism of co-activators involved in TCF/LEF-dependent Beta-catenin transcriptional activities and their functional consequences EZH2 MYC SATB1 AXIN2 CTNNB1 HDAC1 FOXM1 TCF7L2 DKK1 MMP2 TRIB3 GPR49 CCND1 PMC8143357__F4 Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering SMAD1 DKFZp781O1323 BMP2 SMAD4 PMC7564852__F4 Schematic representing the molecular mechanism of transcriptional repression in TCF/LEF-dependent Wnt outcomes BCL9 DACT2 LATS2 APC CTNNB1 PMC3544722__F9 Enhancement of Auranofin-Induced Apoptosis in MCF-7 Human Breast Cells by Selenocystine, a Synergistic Inhibitor of Thioredoxin Reductase BAX BAD MDM2 PMC7564852__F5 Chromatin modifiers involved in Beta-catenin-dependent transcriptional regulation and their roles in the Wnt pathway TRRAP DOT1L HDAC1 ARID1A KDM1A ARID1B EZH2 SETDB1 HDAC2 SIRT1 KDM4D CTNNB1 PMC8323716__F1 Aberration of EZH2 signaling in cancer STAT3 DDB2 PIK3IP1 NOTCH1 RORA PMC7337081__F1 Modular Organization of Cis-regulatory Control Information of Neurotransmitter Pathway Genes in Caenorhabditis elegans TF BAGE ACHE MAPDA ChAT ACE2 PMC4142723__F2 SIRT6 as a master regulator of glucose metabolism TF JUN SIRT6 PMC6390351__F8 Schematic representation of TLR and JAK-STAT pathways postulated in the slug I ECSIT TRAF4 TRAF3 TRAF6 MYD88 PMC3097943__F1 Role IL-6 signaling in CCA inflammation-related epigenetic regulation STAT3 MAP3K8 EGFR NF2 JAK1 PMC8998991__F4 Mammary Gland: Basic Structure and Molecular Signaling during Development PRLR STAT3 DDR1 HGF EGFR GSK3B NRG3 IGF1R AREG RHO ID1 GATA3 STAT1 IGF1 ADAM17 PRL BMP4 HEL-S-11 TBX3 PTH GHR PMC8583405__F7 Curcumin Alleviates the Senescence of Canine Bone Marrow Mesenchymal Stem Cells during In Vitro Expansion by Activating the Autophagy Pathway ATG12 ULK1 SOX2 PMC4002295__F1 Schematic presentation of the rationale of targeting PARPs for cancer therapy BRCA1 BRCA2 SSB PMC4809369__F2 LIF/JAK/STAT3 signaling pathway in mouse ESC self-renewal GBX2 STAT3 PIM1 LIF SOX2 TBX3 SOCS3 GRB2 PMC6549576__F2 ERK signaling pathway was hyperactivated in the patient's tumor tissue ZAP70 HEL-S-76p BAD DDR1 LAT EGFR PIK3R1 MYC ADCY9 ATF1 PRKAR1A SRC CSF1R CACNA1A JUN KIT PTK2B HMGN1 PAX6 KRAS FOS COL4A6 RAP1A PDGFRA NTRK1 ELK3 GRB2 RET PMC7564852__F1 Wnt canonical (Beta-catenin-dependent) pathway TF RNF43 APC LRP5 ZNRF3 LRP6 GPR49 CTNNB1 PMC4345324__F8 G-protein-coupled receptor controls steroid hormone signaling in cell membrane ADRBK1 USP1 PMC11015710__F2 Rosacea: Pathogenesis and Therapeutic Correlates MMP2 MMP9 TNF PMC4323172__F1 Both ligands and receptors are single-pass transmembrane proteins composed of different structural domains EGF ADAM10 FURIN RBPJ PMC3608206__F4 Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate STAT3 EGF SOX11 LIF SOX2 SOX3 SHH PMC4809369__F6 Activin/Nodal signaling pathway in human ESC self-renewal SMAD2 NODAL PMC4809369__F3 Canonical Wnt/Beta-catenin signaling pathway in mouse, rat and human ESC self-renewal ESRRB CDX2 TCF3 KLF2 APC LRP5 LRP6 CDX1 LEF1 CTNNB1 PMC4809369__F4 FGF signaling pathway in mouse, rat and human ESC self-renewal FGF7A FRS2 GSK3B GRB2 PMC4151534__F2 IL-1A and IL-1B synthesis and signal transduction pathway IL1R2 CSA2 IRAK1 TRAF6 IRAK4 IL1B MYD88 PMC3691915__F8 Regulators of mitochondrial biogenesis and function LPL TG NDUFB6 CD36 FOXO1 IRS1 PMC7378170__F1 Possible mechanisms through which major metabolic pathways contribute to the milk fat globule (MFG) size development in the mammary epithelial cell TG PSD PEMT PC PMC8235708__F1 Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications IFNG HEL-S-90n IL16 IDO2 PMC6386897__F4 MiRNA-gene-pathway interactive map PIK3CA JUN RASGRP3 PIK3CD AKT3 PTEN KRAS RAC3 PRKAA1 MAPK3 MAPK14 HRAS PLA2G10 FOXO4 FOXO1 FOXO3A PRKCA MAPK7 NRAS RRAS2 PMC8193257__F1 Progress of Breast Cancer basic research in China PTX3 SETD4 CCL18 USP15 CCR5 EGFR PROCR TSPAN8 CCL5 BTN3A3 IL1B PMC8193257__F2 Progress of Breast Cancer basic research in China POU2F2 BMP4 NAMPT FOXF2 MTOR CCL2 TEAD4 PMC6834480__F2 NKG2D/NKG2DL interaction activates NK cells ZAP70 SYK GRB2 PMC3865866__F8 The FBXL2- and PTPL1-dependent regulation of the PI(3)K pathway PTEN IRS1 PMC3742550__F3 Intracellular 1-carbon metabolism (simplified), emphasizing pathways relevant to the text TH MTHFD1 DHFR MTRR TYMS MTR AHCYL1 PMC9310545__F1 Signaling pathways producing pro-inflammatory cytokines SYK GSDMD MAVS NLRP3 AIM2 IRF3 IRF7 TNF PMC7246017__F3 Complement activation and vasculopathy in coronavirus disease 2019 (COVID-19) VWF ACE2 PMC3187613__F5 Signaling pathways that regulate mammalian autophagy RHEB TSC2 BAD TSC1 UVRAG PTEN PMC7305712__F2 Metabolic liver disease in diabetes – From mechanisms to clinical trials INSR INS PMC6884041__F1 Neutrophil immunometabolism in cystic fibrosis SP1 NLRP3 IL1B PMC2939720__F1 Viral hijacking of the host ubiquitin system to evade interferon responses TBK1 STAT2 IRF9 TANK TLR9 IRF3 IRF7 TRAF3 TRAF6 MYD88 STAT1 TLR3 IFNAR2 IFNAR1 TLR7 ISG15 JAK1 TYK2 PMC6834480__F5 Strategies for targeting the NKG2D/NKG2DL axis for cancer immunotherapy ATR MMP14 ADAM17 MMP2 ATM ADAM10 PMC6770832__F1 Map of potential pathways and their potential interactions activated by a soluble factor- radiation-induced bystander effect (RIBE) signal JUND TRADD PCNA TAB3 IL6 TGFBR1 MAP3K7IP1 CDK6 COX2 TRAF5 CDK2 MDM2 TRAF2 CDK4 PMC5288579__F10 Group I Paks as components of the Ncad/Cdo signaling pathway CDC42 CDH2 PAK1 CTNNB1 PMC11938789__F7 The role of ZBTB6 in BC proliferation STAT3 ZBTB6 PMC5336479__F5 Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines using TMT 10-plex Isobaric Labeling CDC42 ERBB3 SHC1 ERBB4 PIK3R3 ERBB2 CDK2 RAB9A GRB2 MTOR PCTK1 IRS1 PMC6770832__F6 Hypothetical signalling pathway that illustrates how the various pathways in this review may be connected, which is partially informed by preliminary research BAX FAS TGFB1 FOXO3A TGFBR1 PMC9095530__F2 Molecular insights into the pathophysiology of doxorubicin-induced cardiotoxicity: a graphical representation RIPK3 STAT3 TRADD C2 MLKL TNF FADD PMC8508555__F4 Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential KEAP1 NQO1 MAF SFN PMC3197649__F6 Patient-Specific Data Fusion Defines Prognostic Cancer Subtypes PRMT1 UBE4B SMAD9 IDH3B FGF8 FGFR2 RB1 EPHB2 PELP1 HAX1 PLCG2 AP2A2 KIFC3 ARHH ABCB11 TGFBR3 STK24 PTK2B PTMAP7 SPRED1 FBP2 TRAF5 SNW1 SDC2 CDK5RAP2 MRPL44 DDT TP73 BIRC7 IMMT WASL CBX1 NEFL RUNX2 UNC45A CTDSP1 ZNF592 KIAA0513 MNAT1 WWOX RIPK1 CCNB1 INCA1 RBL2 KIT EPHA4 hEMMPRIN CHD3 PTPRS ZBTB16 PMC10541724__F7 Schematic illustration showing that CSSC-EVs mediated the LESC phenotype by regulating the Notch1 pathway through miRNAs HES1 NOTCH1 PMC3197649__F3 Patient-Specific Data Fusion Defines Prognostic Cancer Subtypes MYBL2 COPS5 CYCS CCNA2 KIF23 BIRC5 RRM2B SRC FBXO5 ATAD2 NBN IFI16 TINAG ELMO1 AURKB PLEKHM1 CDK2 CENPA MCM2 TP53RK HEL113 CDC20 ANAPC7 MAPRE1 PRKRA NEFL CDT1 COL3A1 BLM KPNA2 FOXM1 HEL-S-80p ZHX2 PRC1 CHEK2 KCNK15 CEBPZ POLR1C CDCA8 ZHX1 CCND1 PAG1 PTPN1 EIF2S2 BMP7 FABP4 TERF1 PTTG1 CCNE2 PRKDC PARD6B YWHAZ PMC8826423__F1 Interaction of ncRNA and Epigenetic Modifications in Gastric Cancer: Focus on Histone Modification MMP7 AGO2 APC CXCL1 GPRC5A CCND1 CTNNB1 PMC9609612__F9 Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2 OTUD3 HMGB1 MAVS IRF3 SIRT1 RORA PMC9095530__F6 Molecular insights into the pathophysiology of doxorubicin-induced cardiotoxicity: a graphical representation MTCH2 BAX FAS TRADD CASP3 RIPK1 FADD PMC9124578__F3 Origins and roles of osteoclasts in bone development, homeostasis and repair SEMA4D SOST SEMA3A WNT16 LRP5 LRP6 CSF1R PMC2854308__F1 Signaling complexes induced by TNFA to mediate NFKB activation, apoptosis and necroptosis TRADD CYLD TRAF2 FADD PMC3824536__F1 Druggable Drivers of Lung Cancer FGFR4 KRAS PMC11356883__F4 Outline of the DTSAs biosynthetic pathway in Dendrobium species C17orf95 BCAT2 PMC7434719__F1 Diagrammatic presentation of conserved domains of MUC2, MUC6, MUC5AC, and MUC5B MUC5AC MUC6 MUC5B MUC2 PMC3493930__F8 Mechanisms by which AP-1 transcription factor regulates LY6K expression, which activates the ERK signaling pathway to mediate cell invasive motility and metastasis in human breast cancer cells PAX3 GC LY6K PMC7465197__F2 Number of transcriptional factors positively or negatively regulate ARF transcription BMI1 TBX2 E2F2 EGFR SMAD2 EZH2 MYC PMC11314424__F3 Diagram summarizing the effects of salidroside (SAL) on cellular signaling pathways BMP6 SMAD2 BMP2 BMP7 PMC9523165__F1 Anticancer potential of cryptotanshinone on breast cancer treatment; A narrative review IGF1 FOXO1 PTEN IGF1R IRS1 PMC5528296__F2 PI3K signalling regulates both choline and glucose metabolism PTEN TIGAR MTOR MYC PMC4975451__F8 PI-103 and Quercetin Attenuate PI3K-AKT Signaling Pathway in T- Cell Lymphoma Exposed to Hydrogen Peroxide BAD PTEN PMC5923349__F1 Hippo signaling pathway in Drosophila and mammals LATS1 LATS2 PMC8859461__F1 Type-I Interferon Signaling in Fanconi Anemia FANCE FANCD2 FANCG ID2 FANCM FAAP24 FAN1 FANCL FANCA FANCC FANCB PMC5923349__F2 Hippo signaling pathway and the anti-neoplastic immune response IL10 CSF1 CXCL5 CXCL1 IL8RB CCL2 PMC11274826__F6 Osteopontin: A Key Multifaceted Regulator in Tumor Progression and Immunomodulation CDH2 CXCL9 CD200 FAP CD163 PMC5923349__F3 Hippo signaling immunomodulatory functions NLRC4 CXCL1 IRAK1 IRF3 CXCL2 IRAK4 IL6R SETD7 MYD88 PMC11274826__F3 OPN in the regulation of various signaling pathways STAT3 EGFR BRAF HIF1A ATF4 ZEB2 MTOR CTNNB1 PMC5923349__F4 Leukocyte-intrinsic Hippo pathway functions LATS1 LPL HEL-S-92n BCR CCR7 RAB13 CD19 ARHA FOXP3 PMC11274826__F4 Diagrammatic representation of multifaceted function of OPN in various tumors CDH2 CD44 CSA2 HEL-S-133P EGFR GSK3B HEL-S-28 ATF4 MTOR SOX21 CTNNB1 PMC6927982__F7 Predicted pathway illustrated that IL1B and MALT1 were significantly upregulated in the NF-kappa B signalling pathway COX2 IRAK1 TRAF6 IRAK4 MYD88 PMC6562915__F2 Illustration of the main signaling pathways activated upon Ang2 binding to endothelial cells FYN FOXO1 FES RAC1 PMC4546937__F2 COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING IL13RA1 IL13RA2 CTNNB1 STUB1 PMC4546937__F3 COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING SOCS1 RHEB MLST8 TSC2 TSC1 JAK3 SOCS5 SOCS3 JAK1 DEPTOR PMC7103888__F2 Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders ROBO1 USP9X TRAF6 USP48 SLIT1 MYD88 USP14 STAT1 DCX USP36 USP33 SLIT2 USP4 USP12 USP18 USP22 USP46 CYLD PMC3160087__F7 Model of the role of the Nodal and Cripto signaling pathways in mouse XEN cell differentiation SMAD2 CRIPTO SMAD4 NODAL PMC8400201__F1 Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin ATG14 MTOR PMC7969609__F9 MAPK signaling pathway MAX ECSIT FAS RAF1 TRADD FRK CD14 TNF DAO FLNA MEF2C MYD88 NLK MIP TRAF2 PMC8403172__F7 The proposed regulatory mechanism of ARRB1 in this study ATF4 EIF2A TNF PMC8621917__F2 Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention STAT3 BAD GSK3B MTOR CTNNB1 PMC8125972__F1 Impact of Epigenetic Modifications in Myeloid Malignancies EZH1 FLT3 TET2 GATA2 SUZ12 ASXL1 NPM1 NRAS EZH2 KRAS HEL-S-26 PMC3913902__F4 Induction of NLRP3 inflammasome complex by the inorganic crystal HZ SYK NLRP3 TXNIP LYN SRC PMC2360674__F8 Schematic of porphyrin-synthetic pathway to illustrate potential control points for increased PpIX accumulation CPO MB PMC8520510__F4 Identification of cell cycle as the critical pathway modulated by exosome-derived microRNAs in gallbladder carcinoma WNK1 ABCC1 PXN SMAD2 ARF6 NRP1 SOCS2 BNIP3 HIF1A MYC ADD3 BMI1 RB1 NID1 CDK6 FYN SOX9 ITGB8 E2F3 SRGAP1 NRAS SMO ZEB2 SOX4 MSH3 SP1 TNFSF13 KDM5B SPTBN1 CAMK1D ITGB3 SCN5A IRS1 SET BCLAF1 RBX1 HBEGF DFFA BCL2 ITSN1 PPM1D ZNF547 DHFR NEDD9 TGFBR2 ADAM17 ROCK1 HDAC11 KIF20B FLII RREB1 IL10 YES1 PIM1 TLN2 ARHA HEL-S-30 RAC1 RPA1 MACC1 CFTR KLF5 IFNB1 CD40 MYOCD PPP3CA WNT4 MDM2 HDAC2 PKLR CDH2 ACVR2B DICER1 PRPF38A ATP1B1 HEL-S-28 ERG VEGFA LMNB2 EIF4E BMP1 CBFB MCM10 BRCA1 CDKN1B PREX2 MCM2 IL23R KLF4 FXN HMGA2 CTNND1 BRAF PAK4 IGF1R PTPN13 ITGAV ROBO2 RTKN CCND1 CDK4 HRH1 GPC4 SOX2 FZD7 SP7 NFATC1 IL6 CD47 MAD2L1 CD44 SOCS7 NRG1 MTDH ITGB1 SENP1 HOXA10 PMC8520510__F6 Identification of cell cycle as the critical pathway modulated by exosome-derived microRNAs in gallbladder carcinoma STAG2 DBF4 PCNA STAG1 SMAD2 SMC3 GSK3B SMAD4 CYC1 SKP2 ORC2 CDK7 CDC45 CDK2 MCM2 PMC4676172__F2 Wnt/Beta-catenin signaling and directly related pathways affected by genetic-driven and/or gene expression activation or suppression in primary and/or recurrent tumors of 4 HCC patients MMP7 HCCS APC LRP5 HEL-S-28 LRP6 TCF4 PIN1 CTNNB1 CD44 CDKN2A SOX6 SFRP4 MAP3K7IP1 SOX9 NLK MDM2 SRC SOX4 WIF1 PMC7436103__F7 lncRNA target pathway network in AGPS-silenced U251 cells MIA PMC9075737__F2 Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension? EGR1 SP1 PCNA MMP2 PTEN LCN2 MMP9 PMC7436103__F5 Signaling transduction and pathway network of co-expressed lncRNAs and mRNAs in AGPS-silenced U251 cells PIK3CA PANK3 CREB5 PXN EGFR AKT3 SDC4 IQGAP1 DCTPP1 IGF1R MTOR CCL2 CXCL8 ENPP1 JAM2 IL1R1 EREG SHC3 CCR1 IL1B NME3 THBS1 JUN COL1A2 TLN2 NAMPT ANGPT2 CXCL14 FGF2 SPP1 CD44 HEL-S-125m TLR3 UGDH GYS1 PRKAA2 AK4 PMC6642076__F1 The complement system, showing approximately 50 directly involved soluble and membrane-bound complement proteins CRP C6 C7 HEL-S-62p C1S PLG VTN C4A CR1 MASP1 MBL2 C1QA C2 C9 PMC11790539__F2 Pyroptosis signaling pathway GSDMD DFNA5 MTOR PMC7940950__F2 Four genes (RAC2, CXCR4, CXCL2, and CCL18) were significantly enriched in the chemokine signaling pathway CRK BAD RER1 BAP1 ITK ARHA SHE DOCK2 PMC4859220__F3 Poor tumor T cell infiltration CXCL9 ATF3 CXCL1 CCL4 CXCL10 CTNNB1 PMC3679547__F1 Canonical pathway analysis STAT3 CXCL12 APOE PLG PTPN11 IL6 LPA TNFSF14 ABCG8 ABCG5 HMGCR SCARB1 MSR1 LDLR CXCR4 IL1F10 PMC6333895__F6 Cell migration elicited by chemotactic GPCRs via the GBG–P-REX1–Rac pathway is mainly mediated by Gi over Gq or G13 because of the tight control that GAq and GA13 subunits exert on GBG LPA RGS2 CXCR4 RAC1 PMC12202350__F11 The molecular mechanism underlying EM-2 inhibiting the proliferation of LC and BC cells BAX ATM PMC6792490__F7 Colorectal cancer pathway enriched in KEGG BAX CASP9 MSH6 EGF JUN BAD POLK SMAD2 APC CASP3 ERG MTOR PMC8584291__F1 Senolytics: A Novel Strategy for Neuroprotection in ALS? BAX BAD FAS CDK6 CDK2 APAF1 CDK4 FADD PMC4859220__F4 Scientific rationales of potential therapeutic combinations with PD pathway blockade CD40 CXCL12 TIGIT CCL22 APC CCR4 CTLA4 CXCR4 TNF LAG3 PMC5397509__F1 Central role of RTA in reactivation of Kaposi’s sarcoma-associated herpesvirus (KSHV) from latency leading to lytic cycle STAT3 NFIB SP3 PML IRF3 PIN1 SSB PMC4993636__F4 Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network LIMD1 AMOT HEL-S-28 RHO SRC PMC4993636__F2 Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network PATJ AMOT MOBP PMC5986855__F3 Downregulation of VRK1 by DRAM1 in the autophagic pathway induced by p53 and deactivation of p53 by phosphatases and ubiquitin ligases the proteasome in DNA damage response DRAM1 VRK1 ATM DUSP4 MDM2 PMC5210567__F4 KEGG pathway maps for (A) non-small cell lung cancer (hsa05223) and (B) EGFR tyrosine kinase inhibitor resistance (hsa01521) BAX CASP9 RARA BAD AXL NF1 EGFR HRG ERBB2 PTEN FHIT DAO PMC8002743__F6 Detailed schematic models representing changes in cellular processes with CdSe/ZnS QDs or InP/ZnS QDs in the budding yeast PMC9547189__AF1 miR21 modulates the Hippo signaling pathway via interference with PP2A BB to inhibit trophoblast invasion and cause preeclampsia LATS1 CTNNB1 PMC7378891__F4 Canonical Type I IFN and non-canonical JAK1-and IFNAR2-independent IFNB signaling pathways STAT1 STAT2 IFNAR2 IRF9 IFNAR1 IFI27 JAK1 TNF TYK2 PMC10495361__F5 Joint analysis of Chinese yew seed transcriptome, proteome, and metabolome APRT CYP1A2 RPS15 HPSE CS ETF1 EIF4E MLST8 EIF2S1 PIG59 CDA ADK SKP1 MAP2K1 UHRF1 ADA PMC10495361__F6 Summary diagram of specific metabolic pathways involved in Chinese yew seed germination GGPS1 RPE SDHA HEL60 PSD FDPS FDFT1 LPP PMC12180913__F5 PI3K/Akt signaling pathway in cell migration CDC42 PTEN RAC1 PMC12180913__F6 TGFB/Smad signaling pathway in cell migration CDH2 SMAD2 SMAD4 MMP3 ARHA MMP9 PMC12180913__F7 Wnt/Beta-catenin signaling pathway in cell migration CDH2 MMP7 APC LRP5 MMP2 LRP6 MMP9 RAC1 CTNNB1 PMC4396743__F7 Proposed model of signaling pathways activated in primary NHP microglia in response to B TLR1 TLR4 NOD2 TLR5 CCL2 TNF CXCL8 MYD88 PMC5758607__F8 A schematic for TMZ resistance induced by SCD1 mediated the activation of Akt/GSK3B/Beta-catenin signaling axis GSK3B MGMT CTNNB1 PMC3561517__F8 Overview of the recruitment and modification of PCNA and Pol D by RNF8 involving different DNA damage pathways RAD18 PCNA RNF8 PMC11790539__F5 Ferroptosis signaling pathway GPX4 ETV4 SLC7A11 PMC8161134__F1 Genetics and Epigenetics of One-Carbon Metabolism Pathway in Autism Spectrum Disorder: A Sex-Specific Brain Epigenome? DHFR PMC11790539__F6 Cuprotosis signaling pathway RPL3 ATM FDX1 PMC2643336__F3 From the diet to the nucleus: Vitamin A and TGFB join efforts at the mucosal interface of the intestine STAT3 FOXP3 PMC11790539__F3 Necroptosis signaling pathway TRADD MLKL RIPK1 PMC11790539__F4 Autophagy signaling pathway ATG3 FOXO3A RBM47 BRAF MTOR ATG5 PMC8238154__F8 CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells PPARG SMAD1 CCL22 NFKB2 CXCL1 SMAD2 FHL2 NUPR1 CCL2 CXCL8 RORA FOXM1 CDKN2A PPRC1 CEBPG CDKN2C CEBPD CX3CL1 MLL2 DPP4 AHR ATF4 MDM2 NRF1 NOTCH1 HDAC6 SS18 MMP7 CITED2 IRF9 PDGFA CTSK MAFB EZH2 BACE2 IRF3 NOTCH2 ID3 ATF3 PCSK7 BTG2 FOXO1 WWC1 NFKBIA NRF ING1 PMC3348964__F1 Metabolic pathway for disulfiram in humans MOS WAS CS CYP3A4 PMC6547757__F10 Impact of flight condition on expression of crystallins in the network of proteins associated with ophthalmic disease as defined by Ingenuity Pathway Analysis (IPA, https://www.qiagenbioinformatics.com/products/ingenuitypathway-analysis) RBM38 CRYBA1 HEL-S-101 PA2G4 RPP14 PHF6 PC4 POLR2H EIF4E CRYBA4 TUSC2 NIFK UBTF RMND5A MAF MAPK12 EP300 PMC8238154__F9 CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells CXCL9 HLA-DMB HLA-DQA2 CCL22 HLA-DOB HLA-DQB2 HLA-DRB1 HLA-DOA HLA-DQA1 HLA-DPB1 HLA-DPA1 HLA-DRB5 HLA-DMA HLA-DRA CCL19 PLA2G6 FPR2 IL12RB1 PMC3652659__F3 Marginal zone B cells: virtues of innatelike antibody-producing lymphocytes CD40 IFNG TH CXCL13 GC CD14 CXCR5 PMC5741957__F3 Oxidative phosphorelation metabolic pathway COX10 NDUFV3 COPE ND4 COX17 NDUFA10 NDUFS3 NDUFA11 NDUFS4 SDHD SDHA SDHB CYB ND6 SI ND3 ND2 SDHC COX11 PMC12180913__F2 Cell migration and function during normal wound healing HMGB1 HGF MVP CCL2 PMC8238154__F5 CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells IFNG TGFA PMC12180913__F4 Rho GTPase signaling pathway in cell migration CDC42 RHO RAC1 PMC8859437__F3 Aldosterone-Regulated Sodium Transport and Blood Pressure SF1 STAR EGFR SRC PMC9501954__F2 P16INK4A—More Than a Senescence Marker CDK6 CDK2 MDM2 CDK4 PMC12109847__F2 AKT signaling pathway is known to be regulated by miR-21 through the targeting and suppression of the tumor suppressor phosphatase and tensin homolog (PTEN) RHEB TSC2 TSC1 PTEN PMC12109847__F3 MiR-21 modulates the MAPK/MEK/ERK signaling pathway directly by downregulating the SPRY and DUSPs that normally suppress ERK activation STAT1 RAF1 ATF2 GRB2 PMC4584352__F1 Anti-oxidative effects of astaxanthin in neurological diseases SP1 KEAP1 NQO1 PMC6044036__F1 Metabolic cycles involved in methionine metabolism SPR PC MTR PMC6044036__F2 SAM treatment during hepatocarcinogenesis APEX1 IL6 MYC PMC9032069__F7 Ginsenoside Rh4 Suppresses Metastasis of Gastric Cancer via SIX1-Dependent TGFB/Smad2/3 Signaling Pathway SIX1 SMAD2 SMAD4 CS PMC6073374__F1 Mechanistic target of rapamycin (mTOR) signaling pathway RPTOR FOXO4 FOXO1 FOXO3A FOXO6 DEPTOR EIF4E PMC9310656__F2 Gut Microbiota: A Novel Player in Autoimmune Hepatitis GPBAR1 NLRP3 TLR4 TLR9 AHR IRF3 CYP1A1 IRAK4 MYD88 PMC9273267__F1 Ferroptosis at the crossroads of tumor-host interactions, metastasis, and therapy response TF SLC3A2 SLC40A1 STEAP3 GPX4 ASCL4 LPCAT3 SLC7A11 PMC9096094__F5 Betaine Regulates the Production of Reactive Oxygen Species Through Wnt10b Signaling in the Liver of Zebrafish WNT10B GSK3B CTNNB1 PMC7649723__F1 SARS-CoV-2 replication TMPRSS2 HEL-S-69p ACE2 PMC5968842__F9 Schematic diagram of how LIPUS promotes the Schwann cell viability and proliferation signaling pathway GSK3B CCND1 CTNNB1 PMC8248532__F8 Cryptotanshinone Inhibits the Growth of HCT116 Colorectal Cancer Cells Through Endoplasmic Reticulum Stress-Mediated Autophagy ATG12 AGL ME1 PMC4523298__F3 Conserved and differential networks for the proteins in the PI3K-AKT kinase pathway between breast and ovarian cancer cell lines computed using a Bayesian FDR set to 0.10 MCAM JUN COX2 EGFR PTEN MGMT PMC7409924__F1 Methylene blue may have a role in the treatment of COVID-19 COX2 PLG PMC3703536__F1 Highlights of 10 years of immunology in Nature Reviews Immunology TIRAP TLR4 TLR9 TRAF6 MYD88 PMC4523298__F2 Significant edges for the proteins in the PI3K-AKT kinase pathway for breast (a) and ovarian cancer cell lines (b) computed using a Bayesian FDR of 0.10 MCAM PTEN RAB25 PMC6647277__F5 Curcumin actions on the WNT pathway in cancer therapy STAT3 BAD GSK3B MTOR CTNNB1 PMC12181166__F4 mTORC1 signaling pathway showing genes (or rather their gene products) that reached exome-wide significance in black RHEB RPS6 MLST8 TSC2 TSC1 ULK1 FOXO3A SIK3 FNIP2 FLCN MTOR DEPTOR PMC6647277__F6 Beneficial role of curcumin in cancer STAT3 BAX APC GSK3B TNF PMC9021355__F2 Pathological features of tissues and cell populations during cancer cachexia IGF1 PHGDH FOXO1 FOXO3A SMAD2 LIF F3 IL6 MTOR IRS1 PMC8674571__F1 The Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family TRAF4 SMAD1 DKFZp781O1323 BMPR1A ACVR1 SMAD4 ACVRL1 TRAF6 PMC7139812__F1 Pathological implications of amyloidB (AB), reactive oxygen species (ROS), and neuroinflammation and their role in potential therapeutic approaches for cerebral amyloid angiopathy (CAA) and Alzheimer’s disease (AD) TXN BACE1 ADAMTS13 PMC6073374__F2 Sonic Hedgehog (SHH)/Patched (PTCH1) and WNT signaling pathways APC PTCH1 GSK3B SHH SMO CTNNB1 GLI3 PMC3191732__F11 Hydrolytic metabolism of 2-AG and PG-Gs ABHD12 ABHD6 COX1 PMC3703536__F5 Highlights of 10 years of immunology in Nature Reviews Immunology IFNG STAT3 SYK RAF1 TLR3 TLR4 TLR9 NOD2 TRAF3 MYD88 PMC8716463__F1 DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication MSH6 ATR RAD51 MSH2 MSH3 PCNA BRCA2 NEIL1 SSB PARP1 OGG1 BRCA1 ATM PMC8499579__F7 Niraparib exhibits a synergistic anti-tumor effect with PD-L1 blockade by inducing an immune response in ovarian cancer TBK1 CGAS IRF3 CCL5 CXCL10 PMC3178084__F2 Runx2-deficient cells exhibit suppression of genes by insulin at multiple stages of the signaling pathway SOS1 EBP LDLR IGF1R GRB2 RUNX2 PMC7665242__F4 Cooperative participation of epigenomic and genomic alterations in the clinicopathological diversity of gastric adenocarcinomas: significance of cell adhesion and epithelial–mesenchymal transition-related signaling pathways HGF MAK EGFR PMC3429538__F5 Highlights from this issue DRAM1 ERAL1 PMC5225396__F1 Possible roles of lncRNAs played in the context of RNA-RNA interactions BMPR2 STAU1 ADAR ITGB8 ACVR1 GNB4 ANAPC5 TGFBR1 PMC6843035__F5 Phosphoinositide signaling pathway in renal collecting duct cells PIP5K1A PLCB4 PRKD1 PRKCE P2RY2 PIP5K1C PI4KB PRKCH PMC3946772__F1 Non Alcoholic Fatty Liver Disease, Hepatic Insulin Resistance and Type 2 Diabetes LPA PNPLA3 G0S2 PMC3985519__F3 Down-regulation of the clotting cascade by the protein C pathway APC ARHA RAC1 PMC2819802__F1 Activation of apoptotic and survival pathways by TNF TRADD GADD45B TNF TRAF2 FADD PMC5855617__F1 Cancer-fighting mechanisms of BP AXL SOX2 EZH2 PMC9468722__F3 Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review STRA8 CRABP2 LRAT RDH10 ALDH1A2 PMC7412871__F3 Transcriptional Regulators of Ca2+ Homeostasis RHD CDS2 EGR1 SP1 BCR CDS1 RELB SP3 SP2 PMC9468722__F4 Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review STRA8 SMAD1 MAP3K7IP1 DKFZp781O1323 TAB3 DDX4 SMAD4 DAZL PMC11565213__F2 PIK3CA gene mutation activation of PI3K/AKT/mTOR signaling pathway will resist the action of anti-EGFR monoclonal antibody on EGFR signaling pathway, resulting in resistance to EGFR monoclonal antibody in colorectal cancer patients PIK3CA EGFR BRAF MTOR PMC9028087__F1 MD2 AMP(K)s up the link between lipid accumulation and inflammation in NAFLD TBK1 TLR4 MYD88 PMC2811176__F2 Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth Restriction WRNIP1 TGFB1 INO80D DHX8 RSF1 XPNPEP2 NOC3L CRY1 PRICKLE4 CPN1 CECR2 ZNHIT6 SLC35A5 LPIN3 SLC35A1 FGF2 NR1C1 NR2A1 MRTO4 SPAST RUVBL2 BUD31 KNG1 PMC3570673__F6 SIRT1 in the brain is involved in a number of processes that affect neuronal health, neurogenesis, and behavior SP1 RARB HSF1 ADAM10 YY1 BDNF NHLH2 SIRT1 MAOA HTT PMC4770749__F9 BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling BAX CDK2 CCNA2 FADD PMC8789313__F2 Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives TRIM62 TSLP BCL10 NOD2 PC IL23R PMC10743675__F3 Osteobiologies for Spinal Fusion from Biological Mechanisms to Clinical Applications: A Narrative Review MAML1 SOX9 PTCH1 LRP5 IHH LRP6 SMO RUNX2 PMC10743675__F4 Bone morphogenetic proteins (BMPs) signaling pathways BMP10 GDF8 TGFB1 INHBC NODAL RUNX2 SOST INHBB INHBA INHBE INHA GDF11 DKK1 GDF15 BMP4 PTH1R BMPR2 GDF10 APC LRP5 LRP6 BMP8A BMP6 BMP2 PTH BMP5 GDF9 PS1TP5BP1 PMC6361956__F5 Cerebellum (CB)-specific biological processes in Alzheimer’s disease (AD) brain SVIP NCAM2 HEL107 COMP THY1 WASL FLOT2 VCP GNAS ARHGAP26 NDN MBP NDUFB4 MAP6 SYT2 APP EIF4B GNG10 SNCB ACADS PCP4 APOE HEL-S-84 NUTF2 SNX3 CD47 HEL114 CYB EDF1 OMG RHOB CAPZB NEO1 HAGH PMC5479827__F3 Regulation network of the lectin genes related to immune activities ATXN3 CLEC16A CDC20 LMAN2 IRAK1 FLOT2 CLEC4E EPN3 ARHGAP5 LLGL2 POLR3E HEL-S-130P CBLC MYH9 PROS1 NFKBIA AP2A2 MCM5 PMC11770925__F4 Components-disease-target gene-pathway network CDC42 OGA HEL-S-22 PPARG EPHA2 MMP12 MYH6 EGFR JAK3 CCL5 FABP6 RARA SHBG INSR DPP4 MMP2 SLC5A2 SRC TYMP EPHX2 CD209 NOS2 PADI4 BMP7 KIT MIF TNF IGF2 GCG NR1C1 HEL-S-162eP ADK HDAC8 CASP3 MGAM ADA PMC7419604__F2 Communication between the GI tract and the brain CCK PYY AHR IL1B PMC6471940__F4 Molecular signaling in cancer PTEN MDM2 HES1 CTNNB1 PMC4923163__F3 BDNF and TrkB signaling pathway PTEN GRB2 BDNF PMC10978726__F3 SKP2-p27 axis CDK2 SKP1 SKP2 PMC7996029__F2 Therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3′,5′-monophosphate (Epac) for central nervous system trauma ARG1 RHO MTOR PMC4432743__F8 ERK pathway signaling and outcomes in the M ARG1 PMC3371005__F6 Genome-Wide Association for Sensitivity to Chronic Oxidative Stress in Drosophila melanogaster LPL RPTOR NRCAM ANK2 EGFR SDC1 LIPG GRIP2 GNA15 RPS27 HGS PLCE1 IPP PRKCE HEL-S-68p PLCB1 ALDH9A1 TREH HEL-S-1 NLK DGKZ POLE PMC10978726__F4 Involvement of SKP2 in hematological malignanices BCR CDK2 GRB2 MYC SKP2 GAB2 PMC8770806__F2 Applications and Immunological Effects of Quantum Dots on Respiratory System IL33 IL6 CCL2 IL1B PMC11781165__F1 Intestinal bacteria and their metabolites on physical barriers CDKN1A TLR4 APC CTNNB1 MYD88 PMC9663828__F6 Tumor suppressor DEAR1 regulates mammary epithelial cell fate and predicts early onset and metastasis in triple negative breast cancer SNAI2 SMAD2 PMC7702050__F2 RNAi‐mediated regulation of gene expression RAN DGCR8 XPO5 AGO2 SI DROSHA PMC11781165__F3 Gut microbes and metabolites mediate various signaling pathways related to AP progression GSDMD ATG16L1 NLRP3 ATG12 NOD2 DAP NOD1 ATG5 RAC1 MYD88 PMC8465798__F7 Ginsenoside Prolongs the Lifespan of C. elegans via Lipid Metabolism and Activating the Stress Response Signaling Pathway OST4 KRI1 SCAI INS CP PMC8581311__F7 Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment ERBB3 EGFR IRS1 EIF4E PMC7096357__F1 Co-regulation of Hippo and Hippo-like signaling pathways by Mob family proteins MOB2 STK38 LATS2 MOB4 PMC10312956__F3 Networks of the rare-variant genes associated with suicidal behaviors in AI HSD17B3 STAR HHEX SELL PENK NRP1 CD34 VEGFB STARD5 HIF3A SEMA3A SLC5A9 ZNF30 OPRD1 FLT1 KDR DCTN1 GJA1 PMC8581311__F4 Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment GDNF ERG RET PMC8581311__F2 Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment EGFR FGFR1 PMC3792737__F9 Summary of the interactions identified in this work between Dmrt5 and the secreted ligands and Wnt/Bmp regulated graded transcription factors expressed during early patterning of the cerebral cortex CUX2 EMX2 NFIB PAX6 GLI3 PMC12167289__F1 Schematic summary of signal transduction mechanism of the canonical Wnt signaling in human cells BCL9 PORCN APC GSK3B LRP5 LRP6 CTNNB1 PMC6732511__F2 Optimal management of atypical hemolytic uremic disease: challenges and solutions C6 CFHR3 INF2 HEL-S-62p CFI CFHR1 CFHR2 CFH PLG THBD PMC6219741__F8 The proposed mechanisms of over-activation of UPR to trigger apoptosis ATF3 PTEN EIF2D ATF4 KDM4B EIF2A PMC7468622__F7 TRIM33 affecting renal cancer cell proliferation and EMT through the Wnt/Beta-catenin pathway (requires further experimental proof) CDH2 TRIM35 CTNNB1 PMC5828294__F6 The metabolic changes in the liver of fed and fasted HrasG12S/+ mice.(a and b) Changes in gene expression in the liver of HrasG12S/+ mice under fed (a) and fasted (b) conditions GLUD1 HADHB GOT2 GLS HEL-S-133P LDHB ME1 ACADM PMC5398560__F6 Complement Anaphylatoxins, C5a and C3a, Suppress Interferon-Beta Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway TBK1 BTK DDX41 IRF3 IFNB1 PMC7970221__F1 Bioactive nanotherapeutic trends to combat triple negative breast cancer CDK6 CDK4 PMC3947439__F1 Molecular pathways regulated by PGE2 that are inhibited by aspirin EGFR APC GSK3B TCF4 MTOR SRC CTNNB1 PMC8049958__F12 Hypothesis that autoimmune signaling pathways mediate the pronociceptive effects CRPS patient IgM in muMT fracture mice lacking immunoglobulin HEL-S-62p C4B_2 TNF PMC6797978__F6 Schematic representation of the effects of TAGLN2 on breast cancer metastasis MMP2 CXCR4 PMC6815235__F1 Molecular mechanisms that underlies TRPV1-mediated nociceptive hypersensitivity in the dorsal root ganglion (DRG) neurons from a mouse model of sickle cell disease STAT3 CCR2 TRPV1 ADORA2B CCL2 PMC8603508__F1 Noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways TF ADAR DGCR8 DROSHA PMC5548020__F2 Insulin signaling pathway RHEB CRK TSC2 CPA2 BAD FAS INSR ACD PDK2 MTOR INS PMC5287062__F1 Cellular senescence CDKN2A NF1 ATM PTEN MDM2 PMC7706141__F8 PPI network of all DKKs and their similar genes DKK4 CALU TRH MMP14 LDB2 STARD8 LAMB1 TRAPPC6A PORCN LYAR DKK1 CLEC14A F3 CD151 A2M APP DKK2 TNFRSF12A PARVA AREG ARHGAP29 DKK3 BMP1 FBLN5 GJA4 FGF20 PTH PRSS23 ADAMTS13 LAMA3 AQP1 EMCN PMC5714761__F3 Inhibition of stemness and EMT by IL-32θ BMI1 STAT3 PMC6534050__F5 Proposed model relating canonical and non-canonical Wnt signaling with teneurin-3 expression WNT3A GSK3B CTNNB1 PMC11012151__F7 Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism TFAM METRNL NRG4 PMC6796468__F5 Proposed model of PYCR1 interference on HCC cell proliferation and apoptosis JUN IRS1 PMC9094424__F1 Inborn Errors of the Immune System Associated With Atopy IL25 TSLP IL33 DSG1 CDSN FLG PMC9094424__F2 Inborn Errors of the Immune System Associated With Atopy ZAP70 STAT3 DOCK8 BCL10 LAT ZNF341 CARD11 WIPF1 IL6ST ARPC1B PMC4124796__F1 Signaling pathways of leptin and insulin in the CNS INSR FOXO1 LEPR POMC AgRP PMC8118521__F3 Transcriptional Profiling of Porcine HCC Xenografts Provides Insights Into Tumor Cell Microenvironment Signaling ACTA2 SMAD2 CDKN1B SMAD4 MTOR CCL2 TNF CTGF PMC3920940__F7 Diagram showing the model proposed for the association of EMT, CSCs and the PI3K/Akt/mTOR signaling pathway in CaP radioresistance and the effect of possible action of BEZ235 on radiosensitivity CDH2 CD44 SOX2 MTOR PMC4816188__F1 TP53 pathway in CLL RPS15 ATR ATM MDM2 POT1 BIRC3 PMC11012151__F2 Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism BAD PINK1 PTEN PMC5010719__F1 MET signaling pathway in IPF PIK3CA GRB2 KRAS PMC9180565__F2 Interplay between Mast Cells and Regulatory T Cells in Immune-Mediated Cholangiopathies HRH1 STAT3 JAK3 IL6 FOXP3 JAK1 PMC5867024__F2 Diagram showing the biased activation of CGRP receptors and AM1/2 receptors by ADM2, as well as the downstream signal pathway RAMP3 GAA RAMP2 ADM2 RAMP1 PMC9270311__F2 Effects of Ginsenosides on PI3K/AKT signaling pathway HMGCR FOXO1 GSK3B PMC8321873__F2 Metabolic Strategies for Inhibiting Cancer Development ACLY HEL-S-68p F2 AIP HEL-S-30 PMC9270311__F3 Effects of Ginsenosides on PI3K/AKT signaling pathway BAX PCNA GSK3B BCL2 MTOR PMC3901108__F3 Summary diagram showing the role of ATG16L1 and NOD2 in the autophagy pathway and the defects observed when Crohn’s disease (CD) associated mutations are present ATG16L1 NOD2 ATG5 PMC6189458__F2 Map of autophagy induction ATG101 MAPK1 MAPK14 CAMK1 PIK3R4 ULK1 PI3 ATG14 RB1CC1 CAMK4 MTOR ULK2 PMC11480102__F11 Implications of ITCH-mediated ubiquitination of SIX1 on CDC27-cyclinB1 signaling in nasopharyngeal carcinoma SIX1 ITCH CDC27 CCNB1 PMC3957919__F7 Proposed model depicting the role of IFI35 in negative regulation of RIG-I signaling MAVS IRF3 IRF7 IFI35 PMC7877171__F3 Molecular mechanism by which intermittent fasting (IF) affects tumor cell growth SIRT3 IGF1 PRDM1 PRDM11 LEPR NAMPT PMC1481658__F11 Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity STAT3 POMC PTEN PMC5587179__F2 Processing and digestion of engulfed apoptotic cells utilizes LC3-associated phagocytosis and promotes an anti-inflammatory response ATG12 UVRAG ABCA1 PMC5307356__F6 Untargeted metabolomics of colonic digests reveals kynurenine pathway metabolites, dityrosine and 3-dehydroxycarnitine as red versus white meat discriminating metabolites ID2 ID4 ID1 ID3 PMC6738663__F2 HMGB1, as a priming signalling, involved in the stress-neuroinflammation-mesolimbic dopaminergic pathway HMGB1 NLRP3 BDNF IL1B PMC4156316__F2 Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis FOXM1 GSK3B ARHA CTNNB1 PMC6237563__F6 Schematic representation of the downstream targets of the MVA pathway, depicting its various intermediates (blue), end products (green) and functional implications (yellow) IPP GIP ARHA PMC3359833__F2 Linking pathways to disease: Crohn's disease (from Wang et al CXCR3 STAT3 CCR5 CCR6 STAT4 IL18RAP IL23R TBX21 TYK2 RORA IL12RB1 PMC3027010__F1 Schematic review of the molecular mechanisms linking diabetes mellitus and colorectal cancer IGF1 APC GRB2 MTOR PMC8790872__F7 Novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression FOXA1 GSK3B SETD2 TNF PMC5029635__F14 NFKB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression CASP9 FAS CASP8 TRADD CASP3 IRF3 CCL5 CCL2 FADD PMC8640817__F1 Targeting ferroptosis for cancer therapy: iron metabolism and anticancer immunity GPX4 LPCAT3 FACL4 PMC5793760__F4 TGFB signaling pathways SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC11662157__F2 PI3K/mTOR signaling pathway during early T cell development MLST8 IL7R PTEN CXCR4 HES1 PMC7299409__F5 miR-410-3p is induced by vemurafenib via ER stress and contributes to resistance to BRAF inhibitor in melanoma AXL NF1 EBP BRAF ATF1 YY1 ATF2 TBP PMC6090045__F1 Simplified general overview of glucose, fatty acid, and amino acid metabolism in healthy endothelial cells FAS F2 ASNS PMC6771474__F2 Complement system and crosstalk with other innate immune effector systems in liver IRI, regeneration, and transplantation HEL-S-62p CD14 IL1B PMC6383147__F4 Positive feedback linking oxidative stress with enhanced p62 expression, Kelch-like ECH-associated protein 1 (KEAP-1) autophagic degradation, and stimulation of antioxidant enzyme expression TBK1 KEAP1 ULK1 MAF PMC6311524__F1 The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNA MTHFD2 DHFR TYMS MTR HEL-S-51e PMC2729932__F2 ES-EB system has made possible the identification of multipotent progenitors for both hemato-vascular and cardio-vascular derivatives GATA2 ISL1 NKX2-5 GATA4 PMC9361353__F4 Prevaccination Glycan Markers of Response to an Influenza Vaccine Implicate the Complement Pathway MASP1 C6 MBL2 C7 MASP2 HEL-S-62p C2 C9 PMC2763047__F3 Fibroblast Growth Factor Receptor Signaling Pathway as a Mediator of Intrinsic Resistance to EGFR-specific Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer EREG TGFA EGFR FGF9 AREG FGF2 PMC11761653__F11 Seq2Hybrid recovers Ilamycin G BGC FH AMT HEL-S-5 CS PMC2763047__F2 The Fibroblast Growth Factor Receptor Signaling Pathway in Non-Small Cell Lung Cancer EREG HGF TGFA IGF1 EGFR FGF9 IGF1R AREG IGF2 FGF2 PMC7690341__F1 Pyrimidine nucleotide synthesis and chemical structure of PTC299 CAD UPRT CDA UCK1 UCK2 UMPS PMC4560835__F1 Recurrent 2,8-dihydroxyadenine nephropathy: a rare but preventable cause of renal allograft failure PNP XDH ADA PMC6313617__F1 Metabolism pathway of capecitabine and 5-fluorouracil (5-FU) DHFR PMC8463266__F8 Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NFKB pathway through microbiota–gut–brain axis COX2 TLR4 LBP MYD88 PMC10887009__F4 MR suppresses gastric cancer development by inhibiting GSCSs EGFR RAB37 ATG5 PMC4160635__F1 Genomic aberration of the proliferative and invasive pathways of glioma signalling EGF PTEN RAC1 PMC4293489__F1 Activation of TLR4 by LPS TIRAP TLR4 CD14 LBP MYD88 PMC4293489__F2 Participation of CD14 in TLR4 signaling pathways triggered by sLPS and rLPS TLR4 CD14 MYD88 PMC2919655__F3 Diversity in Post-Transcriptional Control of Neutrophil Chemoattractant Cytokine Gene Expression IL17RC IL1R1 TRAF6 IRAK4 MYD88 PMC4910912__F1 Union of active TF-miRNA regulatory pathway in CDDP resistance SLC3A2 JUN TGFB1 HMGA2 BCL2A1 SNCA PTGS2 CCL2 PARP1 KRT19 STAT1 CEBPA MT2A LIN28A SLC45A3 MUC1 FGA HBB PMC9563287__F1 Richter Syndrome: From Molecular Pathogenesis to Druggable Targets BTK BCR PLCG2 NOTCH1 PMC3967167__F1 Schematic drawing of the PI3K/Akt signaling pathway TSC2 BAD PTEN PMC11214488__F8 GSK2334470 attenuates high salt-exacerbated rheumatoid arthritis progression by restoring Th17/Treg homeostasis SGK1 HEL-S-133P PDPK1 HK2 PMC5402284__F6 Transcriptome profiling of sulfate deprivation responses in two agarophytes Gracilaria changii and Gracilaria salicornia (Rhodophyta) GC PTS STS PMC3967167__F5 PI3K/Akt-mediated mTOR activation positively regulates protein synthesis RHEB MTOR EIF4E PMC7465316__F2 Functional proteins association networks identified by differential proteomic analysis and relative Venn diagrams HSP90AB1 ALB HEL-S-273 RPSA HEL-S-269 NUDC HEL-S-1 RPLP2 HEL-S-100n LMNB2 HEL2 PS1TP5BP1 PMC11711130__F6 SPC enhances Th9 cell differentiation and function by upregulating Smad3, STAT5, and Beta-catenin signaling pathways, mediated by increased mitochondrial ROS SMAD2 CTLA4 LAG3 PMC5574319__F11 Signaling pathway changes triggered by HLJDD and its three principals PI3 PRX IL2 PMC8151284__SF1 Attenuation of Oxidative Stress and Inflammatory Response by Chronic Cannabidiol Administration Is Associated with Improved n-6/n-3 PUFA Ratio in the White and Red Skeletal Muscle in a Rat Model of High-Fat Diet-Induced Obesity FAS COX1 COX2 IRS1 PMC8814716__F8 miR-154-5p Affects the TGFB1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1 TGFB1 SMURF1 SMAD2 SMAD4 PMC9481929__F8 Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin RAC1 CTNNB1 PMC11641539__F12 Diagram illustrates the neurotrophic activity of FVSE via activation of the Trk-B receptor in the Neurotrophin signaling pathway NGF BCL2 GRB2 BDNF PMC3310713__F3 Dual nature of Myc induced DDR ATR ATM MYC PMC9180978__F3 Soluble Epoxide Hydrolase and Diabetes Complications BAX NLRP3 ATF4 VCAM1 TNF NOX4 PMC3563272__F4 Eukaryotic Phospholipid Synthesis and Editing.G3P produced by GPDH is converted to PA by sequential acylation reactions regulated by GPAT and LPAAT PGP PSD HEL-S-5 PC INS PMC5590227__F1 The STAT3 pathway and therapeutic targets STAT3 EGF PTPRS EGFR SRC MYC CCND1 PMC7655627__F2 The mTOR pathway in liver cancer: from molecular genetics to targeted therapies SLC7A6 PIK3CA TSC2 TSC1 PIG59 GLS BRAF PTEN MYC KRAS CTNNB1 PMC7655627__F1 The mTOR pathway in liver cancer: from molecular genetics to targeted therapies MTHFD2 RHEB TSC2 CAD TSC1 PTEN DEPTOR PMC6584411__F7 Mechanism diagram CDH2 CDK6 CCNE1 MMP2 CDK2 MMP9 CCND1 CDK4 PMC7937231__F10 Bacterial invasion of epithelial cells pathway (KEGG ID: hsa05100) in the CoNS vs HEL114 CRK CAV2 ARPC4 CBL ARHG WASL HEL-S-28 ARHA CLTC PMC3407530__F5 A simplified model for p80HT targeting the IL-10-Stat3 signaling pathway to promote plasma cell expansion and tumor development STAT3 CCND2 JAK1 CCND1 TYK2 PMC8745127__F2 Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment BAX GRB7 PINK1 FIS1 INF2 OPA1 MFN1 MFN2 PMC9585222__F7 Improvement of gut-vascular barrier by terlipressin reduces bacterial translocation and remote organ injuries in gut-derived sepsis GSK3B CTNNB1 PMC8073943__F5 EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer EZH2 PTEN EPHA3 PMC4287801__F1 Molecular pathogenesis and therapeutics of Marfan syndrome (MFS) TF TG FBN1 SMAD4 MAP3K7 PMC3160745__F1 PI-3K/Akt signaling pathway BAD GSK3B PTEN MDM2 MTOR IRS1 PMC11354507__F1 SARS-CoV-2 entry, mitochondrial damage sensing and innate immune dysregulation TMPRSS2 TBK1 CGAS PINK1 MAVS NLRP3 ATG9A TLR9 IRF3 TRAF3 ACE2 PMC11354507__F2 Inflammation triggered by macrophage after SARS-CoV-2 infection TMPRSS2 STAT3 TBK1 CGAS MAVS STAT2 IRF9 TLR9 TLR5 IL6 TRAF3 TRAF6 MYD88 STAT1 TLR1 TLR7 JAK1 TYK2 ACE2 PMC11809390__F8 Constitutive DRD4 activates TGF‐B receptors independent of ligands to promote CRC metastasis TGFBR2 BMPR2 SMAD9 SMAD1 DKFZp781O1323 SNAI1 DRD4 SMAD2 SMAD4 SET TGFBR1 PMC5779628__F11 Excitation–transcription coupling responsible for maladaptive metabolic and antioxidant remodeling in HF TFAM RYR2 TH PPARG NR1C1 RXRA MCU BDNF NRF1 NNT PMC6444160__F6 Networks of Ingenuity Canonical Pathways results of mRNA of APP/PS1 and SAMP8 mice brain tissues RASD1 BOC PLK2 S100A8 MYT1 CTNNA3 KCNA1 E2F3 CENPU LPL PENK SYNE2 RELN HOXB4 TACC2 USP3 CENPA RET TP73 TH FGF13 GLT8D2 SHANK3 COBL RARA RARB FST GABPB2 EPHX4 ABLIM1 DNMT3B HOXB5 CAV2 THBS1 PTN EMILIN2 HOXB6 SPP1 CD44 LYPD1 JMJD1C HOXB7 EMX1 RPRM PCDHA12 RPP25 KRT80 PRUNE2 TNFRSF11B ZNF76 PMC3242418__F1 HER 2: Biology, Detection, and Clinical Implications TF EGF TGFA HRG PMC3471161__F1 VEGF pathway and the site of action of the inhibitors VEGFB VEGFC VEGFA PMC3964016__F1 Cl− channels and proposed functions in vascular smooth muscle cells CLCA1 CFTR EEA1 RAC1 PMC6320922__F1 Drosophila Jak/STAT signaling components and the corresponding human homologs and their protein families SOCS1 BRWD3 STAT3 REST IGF2BP1 STAT2 IL6 HEL-S-97n PHIP BPTF EYA1 STAT1 CEBPA EYA2 STAT5B CEBPD SOCS5 PIAS1 CSK STAT4 SRC BCL6 PMC8163803__F6 Transcriptome analysis of MBD5-associated neurodevelopmental disorder (MAND) neural progenitor cells reveals dysregulation of autism-associated genes CHAC2 MBD5 FOXG1 PMC4381506__F2 Transcript abundance of genes related to central metabolic pathways under different conditions in K CD2 SP1 TK1 HEL-S-49 AIP PMC4838297__F6 Diminished COX-2/PGE2-Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells TRADD COX2 TRAF2 PMC3416387__F5 Proposed metabolic pathways for central carbon and nitrogen metabolism in Y88 during glucose growth, based on protein identifications (dark gray ovals) and the presence of their corresponding genes in the Y88 genome SDHB NIFK FH HEL-S-162eP MAL PTS HBD TNLG7C CIT PMC9332298__F2 PNPLA1-Mediated Acylceramide Biosynthesis and Autosomal Recessive Congenital Ichthyosis ELOVL4 CERS3 TG ACSL1 DGAT2 ABHD5 CYP4F22 ELOVL1 KDSR PMC2537575__F5 NFKB canonical signaling pathway from IPA ZAP70 EGF NGF LTA TGFA TIRAP PLCG2 RELA RELB TRAF2 LCK PMC7657020__F3 Predicted interaction map of SARS-CoV-2 proteins and top 20 host proteins associated with cytokine signaling pathway and Neutrophils degranulation SNAP23 TMEM30A STAT3 CD59 EGF C3AR1 EGFR MAPK8 VAMP8 ATP6V0C NRAS CYBA SRC CCND1 UBB GAA UBC TNF HRAS ITGAM UBR4 STOM NFKB1 RELA CMTM6 ADAM10 CYBB PMC3817742__F7 ABCB10 and heme synthesis pathway ALAS1 ALAS2 ABCB10 PMC4068075__F3 Consequences of EMT on innate signaling RELA TRAF1 IL6 TRAF3 CDK9 PMC7549355__F1 Hypoxia-inducible factor (HIF) and examples of long non-coding RNA (lncRNA) involvement EZH2 VHL PMC6413748__F3 Synthesis pathway of cardiolipin from lysophosphatidylcholine and lysophosphatidic acid PGP HEL-S-5 PTPMT1 PMC5023675__F1 TNF-Alpha-activated canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) signaling pathway TRADD TRAF2 PMC4957230__F4 Transcriptome sequencing wide functional analysis of human mesenchymal stem cells in response to TLR4 ligand POPDC2 NINJ1 TRAF3IP2 CSF1 TNLG7A IFIH1 SDC4 IRAK2 TAP1 SOCS3 DHX58 CCL2 IL15RA BAMBI LRIG1 NLRP3 HLA-F TNFAIP2 PIM3 USP18 CX3CL1 IRAK3 TNIP3 ISG15 OAS2 CCL1 CSF2 SELE LIF SERPINA1 CXCL6 ITGB3 CXCL10 SPP1 CXCL11 HIVEP3 TRIM25 MAFF PMC9241180__F7 circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer GSK3B MTSS1 CTNNB1 PMC10378150__F1 STAT3 deficiency prevents GVHD in target organs while preserving GVL activity in lymphohematopoietic tissues STAT3 MYC PMC7550743__F3 Amino acid metabolism regulates PDAC progression GOT2 CXCL5 GSK3B SLC7A11 MTOR ARHA ME1 KCNN4 KRAS FOXO3A HSF1 ASNS GABRP PMC2815894__F2 Network of ABA-induced stomatal closure GC HEL-S-84 PC RAC1 PMC10447124__F8 Mapping of Rap1 signaling pathway in NI vs LAT NR1C2 ARHA IVL GNAS HRAS CRK INVS PORCN AFDN NOTUM SRC PS1TP5BP1 PMC7073900__F1 Key hallmarks of the ferroptotic pathway of cell death GPX4 FACL4 ALOX15 PMC8653577__F2 Maturing heart muscle cells: Mechanisms and transcriptomic insights ERBB4 HIF1A MTOR PMC2940871__F3 Metabolic reactions involving the PGM2 (adapted from ) RPE XK PGM2 XDH PMC7988757__F5 Hypoxia-induced inhibition of mTORC1 activity in the developing lung: a possible mechanism for the developmental programming of pulmonary hypertension RHEB SPRY2 TSC2 TSC1 FGF10 PMC8370908__F3 Alteration of protein expression and spliceosome pathway activity during Barrett’s carcinogenesis PRPF19 TH SRRT CRNKL1 DNAJC8 HNRNPD MAL CTNNBL1 PUF60 SYMPK HNRPR DHX15 CPSF1 PMC7652990__F2 Network of pathways involved in respiration, ethylene biosynthesis, and signaling, and ROS production and signaling during the ripening process GLA MYC MTR PMC5023675__F5 Non-canonical NFKB signaling pathway RELB TRAF2 PMC9188076__F5 Pharmacological mechanisms of sodium-glucose co-transporter 2 inhibitors in heart failure with preserved ejection fraction PC PMC9037237__F5 Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction DVL1 SGK1 BRAF PTEN MTOR ARHA TNF SKP2 DEPTOR RHEB HRAS TSC1 GRB10 IGF1 IKBKB FNIP2 CHUK GRB2 SESN2 PMC9037237__F6 Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction MAX CDC42 JUND FAS RAF1 TRADD SOS1 APMAP ATF2 PPP3CA MYC DUSP2 MEF2C CHUK APP ATF4 ECSIT TNF FOS ARAF HRAS NFKB1 HEL-S-102 HP MAP2K1 TRAF2 PMC10887079__F1 Nrf2 signaling pathway RBX1 KEAP1 PMC9289362__F1 Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells BAX PMC4606185__F1 Wnt/Beta-catenin signaling pathway in high glucose condition APC LRP5 LRP6 CTNNB1 PMC3579516__F7 Alliance for Cellular Signaling Plasmid Collection LTK MASTL NRBP2 PLK2 GSG2 SNRK TLK2 PSKH2 SCYL2 STK33 PLK4 MYT1 GRK7 ULK4 DMPK GRK4 ADRBK1 TEC WNK2 ALK SRM FGFR4 WEE1 ITK PKN3 KDR BMPR2 DYRK2 TRIO ROCK2 MAPKAPK2 OBSCN MARK4 SLK TSSK2 ACTR2 ADCK2 FER TBCK CSK PRKX FES NRK MLKL RYK H1-1 MAST2 LATS2 RIPK2 CDK7 INSR ATM CASK SPEG FRK KIT RNASEL HUNK RAC1 BLK PKD1 PLK3 MOS DAPK2 LYN PMC9037237__F4 Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction BAD STK11 ABL2 MCL1 CYC1 PTEN PPP2CA MYC CSF3 POR BCL2L1 TLR4 MTCP1 PRKCA CHUK CD19 HRAS PCK2 RHEB MLST8 G6PC3 TSC2 FOXO3A BCL2 CDC37 GRB2 PMC11597624__F1 Secondary metabolites in invasive weeds, for the synthesis of isopentenyl diphosphate (IPP), dimethylallyl diphosphate (DMAPP), methylerythritol phosphate (MEP), and mevalonate (MVA) pathways responsible IPP MVP MVD PMC6121366__F6 KEGG and BioCarta pathways of proteins encoded by genes related to cell cycle and ROS whose expression was altered in BS-24-1 cells after treatment with ethyl acetate extract of A BAX CASP9 ATR FAS SMS PCNA PERP SMAD4 PTEN MYC SKP2 TSC2 RAD21 CDK7 E2F4 CASP3 CDK2 ATM MDM2 CDK4 PMC6881718__F6 Cellular context of TLR5 engagement by UPEC FliC in the bladder leading to early IL-10 induction CD40 CD80 TBK1 TIRAP TLR9 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 STAT1 TLR4 TLR7 CASP8 CTSK CD14 TLR5 IRF3 IRF7 RAC1 TLR1 MAP3K7IP1 TLR3 LBP FADD PMC3185786__F1 Survival pathways controlled by Tax RAF1 RELA PTEN PMC4396490__F10 Caspase-1–mediated pathway promotes generation of thromboinflammatory microparticles P2RX7 TF IL1B PMC7590701__F6 Network analysis and hypothetical model construction KLF4 CD44 STAT3 RHD RUNX1 BMP4 LEFTY2 FLII JAM3 PS1TP5BP1 FGFR2 PMC8812184__F8 RNA-seq of nine canine prostate cancer cell lines reveals diverse therapeutic target signatures TF BAD GLS EGFR PTEN HRAS NKX3-1 CDKN2A PLAT ERBB2 CDK2 BCL2 FGFR3 MDM2 SRC PMC7017262__F2 Molecular H ERBB3 HBEGF ADAM17 VAV2 EGFR CSK RHO RND2 RAC1 PMC6164133__F1 Intracellular signalling pathways of vitamin A RARA FABP5 HEL111 RBP4 SRC PMC7569467__F1 Schematic graph demonstrates the role of glial cells and the relevant signaling pathway IL10 NLRP3 IL16 TLR4 KMO NPY PMC3083931__F1 Canonical and noncanonical nuclear factorKB (NFKB) activation pathways CD40 LTBR ITCH RNF11 RELA RELB PMC9123888__F6 Possible mechanisms of the effect of melatonin in HDP cells MTNR1A GSK3B MTNR1B CTNNB1 PMC9456295__F2 Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory EEF2 MTOR EIF4E PMC4374983__F2 Serum response factor pathway in myelopoiesis and myelodysplasia with 5q abnormality EGR1 TLR4 CD14 ARHA CTNNA1 PMC4374983__F1 Serum response factor pathway CACTIN ARHA PMC2666387__F7 Proposed Src involvement in HCEC wound healing HBEGF EGFR ERBB2 SRC PMC8750386__F8 Peroxiredoxin 6 Applied after Exposure Attenuates Damaging Effects of X-ray Radiation in 3T3 Mouse Fibroblasts RB1 HEL-S-128m TLR4 CDK2 ATM TRAF6 SSB MYD88 PMC8234963__F6 Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NFKB Signaling Pathway and NLRP3 Inflammasome Activation NLRP3 TIRAP COX2 TLR4 TNF MYD88 PMC3632588__F6 Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta SOCS1 STAT1 JAK1 PMC8835057__F8 Cytokine Receptors—Regulators of Antimycobacterial Immune Response STAT3 JAK1 TYK2 PMC8835057__F9 Cytokine Receptors—Regulators of Antimycobacterial Immune Response STAT3 STAT1 JAK1 TYK2 PMC8835057__F6 Cytokine Receptors—Regulators of Antimycobacterial Immune Response STAT3 STAT1 STAT4 IL23R TYK2 PMC8835057__F7 Cytokine Receptors—Regulators of Antimycobacterial Immune Response STAT1 JAK1 PMC7725871__F2 TLR4 signaling pathway: TLR4 is localized on the cell surface for ligand recognition, some of which are recognized after TLR4 interacting with MD2, even requiring CD14 and/or LBP involvement HMGB1 TLR4 CD14 MTOR LBP MYD88 PMC4011959__F3 The initial stages of vesicle elongation in macroautophagy ATG10 ATG3 ATG12 ATG5 PMC6032341__F3 ATM-dependent DNA Damage Response KAT5 ATM RANBP9 PMC8674037__F6 Activation of AdipoR1 with rCTRP9 Preserves BBB Integrity through the APPL1/AMPK/Nrf2 Signaling Pathway in ICH Mice RBX1 KEAP1 ADIPOR1 MAF PMC4166552__F9 Model of cooperation of PLCB3 in the P.aeruginosa-dependent signaling in bronchial epithelial cells TLR5 PLCB3 MYD88 PMC6174755__F3 Exosomes can regenerate stem cell phenotypes and convert them to CSCs by regulating the Wnt pathway MMP7 ENC1 NRCAM ROCK2 COX2 APC GSK3B ARHA CCND1 RAC1 WIF1 CLDN1 PMC5824910__F1 G-alpha signaling pathway in uveal melanoma TRIO AMOT PTEN RHO MTOR PMC2946515__F3 Mutant epidermal growth factor receptor, EGFRvIII, promotes cell survival and proliferation by preferential signaling through the phosphotidyinositol-3-kinase (PI3K) pathway EGF EGFR MTOR PMC2785881__F3 Sialic Acid Utilisation and Synthesis in the Neonatal Rat Revisited RENBP OGT NANP SLC35A3 GNE PGM3 CMAS NAGK SLC17A5 NPL NANS SLC35A1 PMC6487163__F1 Process and regulatory mechanism of autophagy ATG12 ULK1 MTOR ATG5 PMC11487528__F2 COL10A1 regulates EMT, tumor cell proliferation and metastasis by phosphorylating Smad in conjunction with DDR2 and activating the TGFB signaling pathway CDH2 SOX9 MMP2 COL10A1 DDR2 MMP9 PMC11487528__F3 COL10A1 activates signaling pathways and regulates gene expression CDH2 COL10A1 DDR2 METTL3 PMC6488374__F3 Molecular mechanisms that regulate quiescence and activation of McSCs niche in telogen and anagen, respectively DKK3 EDN2 NFIB SMAD2 EDN1 LRP5 LRP6 COL17A1 HES1 CTNNB1 PMC7059124__F1 Schematic illustration of the autophagic pathway ATG10 ATG3 ATG12 ULK1 UVRAG MTOR ATG5 ULK2 PMC7182350__F1 Rac GTPase activity is regulated by synaptic activation through synaptic receptors that are known to be involved in memory formation such as NMDA, Trk, and Eph receptors ABI2 EPHB2 TIAM1 CYFIP1 EPHA4 BDNF PMC7059124__F4 Hepatotropic oncogenic viruses and their impact on autophagy regulation ATG3 SHB ATG12 ULK1 UVRAG MTOR ATG5 ULK2 SIRT1 PMC2311419__F1 P. gingivalis accelerates gingival epithelial cell progression through the cell cycle WEE1 CCND1 PMC11487528__F4 COL10A1 in malignant tumors CDH2 VSNL1 SOX9 SMAD2 COL10A1 DDR2 FAP METTL3 TUG1 LEF1 PMC6585451__F2 Gut mycobiota in immunity and inflammatory disease IL17F CSF1 MTOR PMC8495217__F3 Different View for an Old Disease: NEDDylation and Other Ubiquitin-Like Post-Translational Modifications in Chronic Lymphocytic Leukemia NEDD8 TNF TRAF2 PMC9241412__F2 Regulatory role of Pin1 in neuronal death BAX PIN1 PMC9120690__F1 Targeting O-GlcNAcylation in ischemic stroke OGA GNPNAT1 PGM3 XBP1 PMC3918861__F2 Induction of apoptosis BAX BAD FAS TRADD FADD PMC3928706__F1 Mechanism underlying GD T cell killing of tumours: GD T cell receptor (TCR) interacts with isopentenyl pyrophosphate (IPP) generated through the mevalonate pathway in tumours IPP MICA MICB PMC12230168__F7 Molecular mechanism of rosmarinic acid synergistically enhancing gefitinib efficacy in EGFR-mutant lung cancer by inhibiting cancer-stromal interactions and miR-21 signaling pathway FAP PMC8073623__F1 New Insights into YES-Associated Protein Signaling Pathways in Hematological Malignancies: Diagnostic and Therapeutic Challenges LATS1 LATS2 PMC9469021__F10 Immunosuppression and apoptosis activation mediated by p53-Bcl2/Bax signaling pathway -The potential mechanism of goldfish (Carassius auratus Linnaeus) gill disease caused by Myxobolus ampullicapsulatus IFNG CTSA IL1B PMC9469021__F11 Immunosuppression and apoptosis activation mediated by p53-Bcl2/Bax signaling pathway -The potential mechanism of goldfish (Carassius auratus Linnaeus) gill disease caused by Myxobolus ampullicapsulatus BAX CASP9 BAD CASP8 CASP12 TNFRSF10A CDK6 CASP3 CDK2 BCL2 CASP10 CDK4 FADD PMC4661094__F1 RPE Necroptosis in Response to Oxidative Stress and in AMD TRADD BMF FADD PMC3118263__F4 Pathway analysis links the differentially expressed gene signatures of the MED29 transduced Hs 700T and MIAPaCa-2 cells to a cellular network involved in cell cycle, cancer, and genetic disorder AURKA LGALS8 HMMR PTPRK AURKAIP1 FOXM1 PTTG1 HJURP NDFIP2 AURKB CDCA8 CENPA HCTP4 PMC1603666__F9 Erk- and PI3K-Akt-dependent cascades regulating mTOR signaling RHEB EGF TSC2 TSC1 MTOR PMC11688305__F1 The structural comparison and similarities between CD4 and LAG-3 ADAM17 APC ADAM10 LAG3 PMC4661094__F2 RPE Necroptosis in Response to Oxidative Stress and in AMD RIPK3 TRADD MLKL TRAF2 PMC7098936__F1 Drugs in development for the treatment of achondroplasia FRS2 FGFR3 CNP GRB2 FGF2 PMC6880832__F7 Schematic illustration of miR-4666-3p and miR-329 are both low expressed in non-QCCSCs and synergistically regulate TGFB/Smad pathway SMAD2 SMAD4 TGFBR1 PMC6563192__F7 DEGs that are located in the neighborhood (putative cis-targets) of DELs and that are associated with Notch signaling pathway and stress granule formation NUMB EIF2A HES1 HES5 PMC3983496__F2 The proposed intracellular signaling pathways regulated by Cx43 hemichannels in bone cells ASB1 BAD PTH SRC CTNNB1 PMC219483__F1 Biochemical pathways of TSH and folate metabolism in Leishmania DHFR HEL-S-64p FPGS PMC11855067__F3 Core genes of key signaling pathway map of tectoridin against ischemic stroke EIF4B BAD RBL2 PTEN CD19 MTOR ME1 IRS1 RHEB TSC2 BCR CD37 RAE1 MDM2 GRB2 PMC8024517__F1 Proposed mechanisms by which innate immune responses not only induce inflammation but also skew emerging adaptive immune responses towards a response that amplifies myeloid cell activation in mycobacterial IRIS or COVID-19 CCL3 CXCL10 CCL2 IL1B PMC5831775__F2 Simplified scheme of the cilia-mediated HH signal transduction pathway in vertebrates KIF7 GSK3B SMO PMC3464365__F1 Linking cellular metabolism with the circadian clock transcriptional complex HDAC3 NCOR1 NAMPT EZH2 SIRT1 PMC8991826__F9 TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway CDH2 BAX MTOR CCND1 PMC7278240__F3 Brain oxytocin: how puzzle stones from animal studies translate into psychiatry OXTR TRPV2 EGFR EEF2 NPY5R PMC4989114__F10 Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate RDH10 BCO1 PMC9694413__F3 Biodegradation and Metabolic Pathway of the Neonicotinoid Insecticide Thiamethoxam by Labrys portucalensis F11 TMX4 TMX3 TMX2 PMC7116063__F7 Signal integration in the (m)TORC1 growth pathway RHEB RILP NPC1 FLCN SESN2 CASTOR1 SLC38A9 PMC8714756__F5 Adaptation Strategies to Improve the Resistance of Oilseed Crops to Heat Stress Under a Changing Climate: An Overview SNRK ABI3 PMC6834478__F2 Mouse models used to study the PI3K/AKT/mTOR axis in PCa RHEB TSC1 PML TTI1 PTEN DEPTOR PMC7236745__F3 NF-kB/E2F/Rb and p53/p21 pathways by proteasome.NF-kB/E2F/Rb pathway: under unstimulated conditions, NF-kB is kept inactive in the cytosol by IkB inhibitor CDC2 CCNO PCNA APC CDK2 MDM2 CCNB1 PMC7116063__F1 Signal integration in the (m)TORC1 growth pathway RHEB FLCN SESN2 CASTOR1 PMC6614068__F6 Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy HEL-S-15 PMC5301350__F7 Differentially expressed genes (DEGs) in photosynthesis pathway in different combinations CYB SP4 SP3 PC PMC6636296__F1 metabolic pathways in cancer cells MTOR CTNNB1 PMC6636296__F2 Network of Wnt signaling regulates tumor metabolism reprogramming TSC2 TSC1 APC MTOR MYC CTNNB1 PMC6142822__F3 Gut-brain communicates with the brain mainly via three pathways of the microbiota–gut–brain axis TGFA IL16 BDNF PMC6535379__F1 Signaling pathways involved on induction of endoplasmic reticulum (ER) stress ATF4 EIF2A XBP1 PMC4162005__F1 Model for regulation of expression/activity of multiple P450s by AKR1D1 CYP8B1 HSD3B7 CYP7B1 CYP27A1 PMC7573490__F4 Interaction of Leptospira interrogans with the innate immune system TLR1 NLRP3 TLR4 NOD2 TLR5 NOD1 IL1B MYD88 PMC4014576__F6 Protein Tyrosine Phosphatases PTP-1B, SHP-2, and PTEN Facilitate Rb/E2F-Associated Apoptotic Signaling CASP8 CASP3 PTEN PMC8931761__F1 Traditional Chinese Medicines as Effective Reversals of Epithelial-Mesenchymal Transition Induced-Metastasis of Colorectal Cancer: Molecular Targets and Mechanisms CDH2 SMAD2 GSK3B SMAD4 ZEB2 PTH MTOR CTNNB1 PMC7234920__F2 The compartmentalization and interplay between the extracellular and intracellular pathways for (acyl-)CoA degradation and intracellular CoA synthesis VNN1 PANK2 PANK3 PANK1 SLC25A17 NUDT7 NUDT19 ACOT8 HEL20 VNN2 PPCDC PANK4 NUDT8 PPCS PPAN COASY PMC8377541__F8 CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/Beta-Catenin Signaling Pathway in Glioma FRAT1 APC GSK3B LRP5 CR2 LRP6 TCF4 CR1 LEF1 AXIN2 CTNNB1 PMC5445305__F7 Characterization of central metabolic model in developing L LPA RPE INVS HEL-S-304 ENO3 HEL-S-162eP MAL PDC PC GIP PMC6936734__F1 Schematic representation of sphingosine-1-phosphate (S1P) pathway SPNS2 SMS SPHK2 SPHK1 PMC12072856__F1 Bacteria antagonize p53 protein by mechanisms of its destabilization or by reducing expression of its mRNA TLR4 EGFR MDM2 PMC4753639__F8 Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation MSRA NOX3 EGFR WAS PMC6629768__F1 Some examples of lncRNA mechanisms that unfold in the cytoplasmic compartment DRAM2 ULK1 PMC2952341__F1 Alteration of Notch signaling in skeletal development and disease DLK2 DLL4 PSEN2 JAG2 PSEN1 DLL3 LEF1 HES1 RBPJ PMC9370431__F5 Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action LPL FAS PMC9312335__F4 High-Temperature Stress Effect on the Red Cusk-Eel (Geypterus chilensis) Liver: Transcriptional Modulation and Oxidative Stress Damage SVIP CASP12 ELF2 BCL2 ATF4 PMC11995091__F2 Sketch represents the impact of nano-encapsulated tea polyphenols impact poultry health GPX4 TLR4 GPX1 MYD88 PMC9370431__F4 Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action VCAM1 IL1B PMC10672284__F1 Multifaceted functions of (AMPs): (A) Depiction of the signaling pathway involved in Gram-negative bacteria-induced infection caused by lipopolysaccharides (LPS) TIRAP TNF LBP IRAK4 MYD88 PMC10670481__F6 Analysis of KEGG pathway and interactive enrichment networks PRMT1 PYGL PDE3B F2 CRTC2 GIP HEL-S-30 CIT PMC2856448__F1 Opposing influences on Foxo cellular localization and transcriptional activity PRMT1 OGT PTEN SIRT1 PMC11674267__F1 Mechanistic pathway of methuosis-induced vacuolization NGF RAC1 PIKFYVE PMC11674267__F3 Schematic summary of alkaliptosis pathway induced by JTC801, a pH-dependent form of cell death STAT3 HMGB1 AGER MITA ATP6V0D1 CA9 PMC5872768__F1 Possible routes of lipid oversupply-induced insulin resistances associated with mitochondrial and endoplasmic reticulum (ER) stress MFN1 MFN2 GPR75 IRS1 PMC11674267__F4 How SNG induces oxeiptosis in colorectal cancer cells based on [20] PGAM5 AIFM1 PMC7465688__F1 Postulated signaling pathways affecting endothelial progenitor cells (EPCs) EGF DKK1 CXCR4 PMC5345629__F5 Validation and interaction networks of the differentially expressed miRNAs PMC7156293__F3 The MyD88‐dependent and MyD88‐independent pathways mediated by TLR4 ligation to induce NF‐KB activation and cytokine gene expression TLR4 MAL IRAK1 IRAK2 PTGS2 TRAF6 TNF IRAK4 MYD88 PMC8892735__F4 Long and short non-coding RNAs modulating EZH2 signaling in cancer MMP14 BRMS1 E2F3 HK2 EZH2 YY1 CXCR4 HNF1A SOX4 PMC2810075__F6 CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts FAS CXCR1 PTEN CTNNB1 FADD PMC3698571__F2 Advances in targeting cell surface signalling molecules for immune modulation CD40 CD27 APC BTLA LAG3 PMC11844401__F1 Four-step protopathway (highlighted in lilac) restores growth of ΔpdxB E PNP PDX1 NR1A2 HEL-S-1a PMC6562762__F8 Hypothetical model of Se homeostasis in brain HEL-S-134P SELENOF GPX4 SELENOP SELENOW PMC7254712__F4 Graph of the ECM–receptor interaction pathway (17) CD44 VWF CD36 NPNT VTN CHAD PMC8892735__F1 Long and short non-coding RNAs modulating EZH2 signaling in cancer SUZ12 EED EZH2 PMC3368236__F5 Sema3E-PlexD1 signaling regulates pathway-specific synapse formation in the striatum DRD1 SEMA3E HEL70 PMC8305917__F3 The Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom IQGAP1 ARHA RAC1 PMC3135645__F1 Coordinated regulation of p53, target of rapamycin (TOR), and insulin/insulin-like growth factor 1 (IGF-1) pathways RHEB IGF1 PTEN MDM2 PMC10304713__F2 SARS-CoV-2 employs different mechanisms to activate the host’s innate immune system MAVS TRIM25 IRF9 IRAK1 IRF3 TRAF6 REL IRAK4 MYD88 PMC3031055__F3 TFM-C-induced alteration to IL-12p40 chaperone interactions PDIA2 DERL1 PMC2670002__F7 Pathway in colorectal cancer (CRC) progression from normal colon to late-stage cancer EPHB4 EPHB2 EPHA2 EPHB1 EPHA1 PMC11012558__F6 RTK pathways STAT3 EGFR PDGFRA IGF1R CCND1 PMC3798952__F1 EpCAM and WNT signalling pathways EPCAM EGF ADAM17 APC FHL2 CTNNB1 PMC11012558__F3 Calcium and Neural Stem Cell Proliferation ORAI1 TRPC7 STIM1 TRPC4 FGFR1 TRPC1 TRPC6 TRPC3 PMC10970237__F5 Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways TSC2 EIF4B TSC1 EIF4E PMC11012558__F4 TRPVs and neural stem cell proliferation EGF TRPV3 IGF1 TRPV2 CS PMC11003748__F2 Clastokines produced by osteoclasts and osteoclast precursors and interaction with their receptors on cells from the osteoblast lineage CDH2 BGLAP EPHB4 STAT3 EFNB2 WNT3A SPHK1 LIF ROR2 LRP5 CTSK SP7 CTHRC1 NFATC1 ROBO1 RHO RUNX2 RAC1 CTNNB1 ROBO2 SPNS2 SLIT3 COL1A1 PMC8620617__F4 Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye LRAT HEL111 RBP4 PMC7140477__F1 Major carbohydrate metabolic pathways FAS GLS C2 PDC PMC11003748__F1 Matrix-derived coupling factors WNT10B BMP1 IGF1 CXCL16 MTOR PMC3564224__F2 Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47 BNIP3 BCL2 SIRPA SRC CD47 PMC7959691__F4 PTP regulation of adhesion complexes and related pathways LATS1 LATS2 TRIO PTPRF PTPN21 GRB2 SRC PTPN6 PTPN13 PMC5597736__F1 Interactions between DNA tumour viruses and the DNA damage response STAT3 ATR ATRIP RNF168 H2AX RNF8 ATM PMC9628250__F2 The Wnt signalling pathway in the energy metabolism of bone remodelling GLS CD36 PMC9628250__F3 The Wnt signalling pathway in the energy metabolism of bone remodelling TCF7L2 SOST APC GSK3B LRP5 CTNNB1 PMC3389016__F3 Anti-Obesity Sodium Tungstate Treatment Triggers Axonal and Glial Plasticity in Hypothalamic Feeding Centers STAT3 CLIC4 MT3 RPL18 HPCAL1 SP1 SLC2A4 ARC PDK2 RPS18 NEF3 PDHX DLAT KSR2 HEL-S-112 TRIB1 FARSB DLD RPS12 MAP2K1 PS1TP5BP1 PMC9265870__F1 Breast Cancer Stem Cells: Signaling Pathways, Cellular Interactions, and Therapeutic Implications LBH RELB APC SOX2 NUMB CTNNB1 MAML1 PTCH1 RELA FOXC1 JAG2 SMO GLI3 PMC9265870__F2 Breast Cancer Stem Cells: Signaling Pathways, Cellular Interactions, and Therapeutic Implications HGF HEL-S-62p LEPR IL7 CCL2 ATG5 PMC5516940__F5 Downregulation of several proteins in the oxidative phosphorylation pathway identified in the global proteomic data for LNCaP-95 androgen resistant prostate cancer cells ND4 NDUFA7 COX17 NDUFA11 SDHD SDHA NDUFB10 SDHB CYB COX2 ND6 COX3 ND3 ND2 SDHC PMC9628250__F1 The Wnt signalling pathway in the energy metabolism of bone remodelling WNT10B MSC WNT7B PMC10037657__F1 Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer NR1C1 MTOR FADD PMC10838672__F1 VEGF protein family and receptor signaling pathway VEGFB VEGFC PIGF VEGFA PMC12181099__F1 Interactive effects of MSC and AML cells on each other CD44 BAX CXCL12 CD80 CCND2 CXCL1 MSC METTL3 CTLA4 HOXB6 PMC10037657__F2 Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer CDC42 MAPK1 PAK1 LIMK1 TWIST1 PMC10838672__F2 RTKs and its related downstream signaling pathways and their targeted therapies for hepatocellular carcinoma EGF HGF EGFR PTEN MTOR PMC10037657__F3 Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer EZH2 MTOR PMC10838672__F3 PI3K/AKT/mTOR signaling pathway and targeted inhibitors TSC2 BAD TSC1 FOXO1 EGFR GSK3B ERBB2 SRPK2 PTEN CCND1 RET PMC4385526__F2 Innate immune evasion of hepatitis C virus infection IFNLR1 MAVS TLR3 STAT2 IFNL3 IFNAR2 IRF9 IFNAR1 IRF3 TYK2 PMC10838672__F4 Wnt on and Wnt off state of Wnt/B‐catenin signaling pathway and therapeutic strategies based on them APC GSK3B LRP5 LRP6 CTNNB1 PMC10838672__F5 JAK/STAT signaling and targeted inhibitors STAT3 STAT1 STAT5B STAT2 JAK3 STAT4 JAK1 TYK2 PMC10838672__F6 Smo‐driven canonical Hh signaling pathway and targeted inhibitors KIF7 SUFU PTCH1 SMO GLI3 PMC8079635__F1 Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes OSM CCL3 LIF IL33 AREG MMP9 FURIN PMC9276080__F1 MicroRNAs and their signaling pathway in mycosis fungoides STAT3 JAK3 IL21R STAT4 PMC9276080__F2 MicroRNAs and their signaling pathway in mycosis fungoides BMI1 STAT3 BRD4 FCRL3 PMC8377203__F2 Unpicking the Roles of DNA Damage Protein Kinases in Trypanosomatids TOPBP1 ATR ATRIP BRCA1 H2AX PAXX ATM PMC8253276__F6 Upregulation of Nogo‐B by hypoxia inducible factor‐1 and activator protein‐1 in hepatocellular carcinoma CDC42 SRC PMC9626809__F1 Sulfur compounds in chronic obstructive pulmonary disease PMC7720622__F2 Estrogen signaling pathway with altered proteins in pterygium tear proteome in highlight TF TFF1 HBEGF TGFA HEL-S-130P PGR EBAG9 EGFR BCL2 GRB2 KRT13 PMC8819303__F2 Aberrant RNA splicing and therapeutic opportunities in cancers SF3B1 U2AF2 PHF5A U2AF1 PMC10159521__F9 miR-613 suppresses renal cell carcinoma proliferation, invasion and migration by regulating the AXL/AKT pathway AXL PMC11992794__F5 Analyze the DEGs within metabolic pathways UGDH HEL-S-162eP GALK2 PMC6953055__F1 HBx-dysregulated miRNA in the P13K/MAPK liver cancer pathway HGF EDN1 PTEN MTOR PMC5668305__F7 The pain related mechanisms of Notch1 and TLR4 signaling pathway TLR4 HES1 NOTCH1 PMC6953055__F2 Dysregulated miRNA in the WNT/Beta-catenin liver cancer pathway TRPS1 APC CTNNB1 PMC6953055__F3 Dysregulated miRNA in the TP53 liver cancer pathway BAX CASP9 FAS CASP8 CDK6 CASP3 CDK4 PMC7493703__F1 Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand–Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib CCL3 CCR5 VEGFA KLF13 PMC6953055__F4 Dysregulated miRNAs in the JAK/STAT liver cancer pathway EBP IL6ST SOCS3 MTOR MYC PMC11932658__F1 n-6 and n-3 HUFA biosynthetic pathway ELOVL2 MYRF FADS2 ELOVL5 FADS1 PMC7729760__F1 Autophagy—A Hidden but Important Actor on Oral Cancer Scene ATG101 TSC2 TSC1 ULK1 MTOR PMC3124877__F1 Pathway of alcoholic injury resulting in the direct production of oxidative stress and the LPS-TLR pathway that culminates in production of cytokines and other inflammatory processes that result in hepatitis of the liver CYP2E1 TLR4 MYD88 PMC9130956__F1 Atypical Cadherin FAT1 Limits Mitochondrial Respiration and Proliferation of Vascular Smooth Muscle Cells EGF ECD FAT1 PMC4238866__F3 Glucose activation of the cAMP-PKA pathway RGS2 TPK1 PDE12 PMC8718071__F8 Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome CA4 BAAT FGFR4 CYP7B1 CYP27A1 PMC7024330__F1 AR mediated gene transcription in different subtypes of breast cancer TF FOXA1 CTNNB1 PMC3579397__F1 Sulfide production HEL-S-182mP SUOX PMC4238866__F1 The Snf1 protein kinase as a central player in the main glucose repression pathway TPK1 FBP1 PCK1 PMC7024330__F2 AR signaling pathway and targeted therapeutic strategies against AR TF CYP17A1 HSD3B1 SRC PMC11050151__F2 Representative scheme of the 15 genes shared by the selected pathways using pathway enrichment analysis NFATC2 PIK3R2 PTPRC PTGS2 FOS PMC7885480__F1 Developmental signaling that govern CSCs and therapy resistance KIF3A APC YAP1 TEAD4 CTNNB1 LATS1 LATS2 TEAD2 NF1 TEAD3 SUFU PTCH1 SHH SMO NF2 GLI3 PMC11050151__F3 Gene association networks that result from entering the list of eight genes—PIK3CG, PTGS2, FOS, PTPRC, VAV1, ITPR3, NFATC2, and PIK3R2—as input into the GeneMANIA software CD3D PIK3CA JUND PIK3R5 NFATC2 EGFR PIK3CD PIK3R2 PTPRC PPP3CA TEC KDM6B FOSL2 TRPM5 PTGS1 ATF4 FOXP3 JUN PAG1 KIT VAV1 PTGS2 RAC1 FOS SEMA4D CBL PTGIS PRKCQ IGFBP7 CD3G CD3E PMC3469610__F6 Schematic diagram of proposed molecular mechanism of p27 downregulation in Fen-induced cell growth in fibroids IGF1 CDK2 IGF1R PMC5392045__F1 Schematic of the stimulator of interferon genes (STING)–dependent innate immune response pathway TBK1 CGAS IRF3 PMC8002044__F4 Potential network of signaling pathways contributing to the chicken lipid metabolism LPL CD36 SCD MSMO1 DHCR24 CH25H CIDEC PMC5133582__F7 Metabolic pathways in hepatocellular carcinoma SCIN SLA DAP ACD PMC8002044__F2 Adipogenesis and fat deposition and their regulation at the transcriptional and post-transcriptional level in the chicken adipocyte LPL GATA2 TG KLF2 DHCR24 FABP4 PMC7500922__F4 Revisiting the PD-1 pathway STAT3 IFNAR1 JAK1 PMC12042674__F2 Signaling pathways regulating melanin synthesis MC1R TYRP1 PMC8873532__F1 Mitochondrial Nucleic Acid Sensing Pathways in Health and Patho-Physiology SSBP1 YME1L1 ATF4 EIF2A PMC7654982__F3 Therapeutic Options to Block the Activation of Hedgehog Signaling Pathway SUFU PTCH1 DHH SHH IHH SMO PMC7920173__F1 Autoimmunity in Acute Poststreptococcal GN: A Neglected Aspect of the Disease C6 C7 HEL-S-62p C2 C9 PMC7654982__F1 Hedgehog Pathway in Female Cancers SUFU PTCH1 SMO PMC7654982__F2 Abnormal Hedgehog Signaling Pathway Leads to Female Cancers SUFU PTCH1 DHH SHH IHH SMO PMC5006394__F2 Metabolism on Foxp3 expression and the generation of Treg cells FOXO1 FOXO3A EZH2 PTEN FOXP3 MTOR SIRT1 PMC6307204__F5 NFKB signalling pathway is involved in endogenous DcR3 expression in HUVECs stimulated by LPS, LTA and zymosan LTA TLR4 IRAK2 TRAF6 IRAK4 MYD88 PMC8843787__F1 Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions TBX2 LOX COX1 COX2 PMC4673016__F1 Transcriptional and chromatin regulation during fasting – The genomic era KLF15 NR1C1 EBP TFEB PMC8009749__F1 Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance SOCS1 KLF4 CERK PTEN IRS1 COXFA4 PMC8063120__F4 Long non-coding RNA (lncRNAs) and microRNAs (miRNAs) involved in osteogenic pathways in Bone Marrow Mesenchymal Stem Cells (BMSCs) SMAD1 SMURF1 SMAD2 APC SMAD6 SMURF2 RUNX2 CTNNB1 PMC7461616__F1 Targeting lipid metabolism of myeloid cells in cancer immunotherapy CD40 FAS CCR2 TLR9 TLR8 TLR7 CTLA4 PMC8055485__F1 Signaling pathways behind the role of CRP in cancer-induced muscle wasting CRP RPS6 STAT3 IGF1 FOXO3A RELA IGF1R MTOR REL IRS1 EIF4E PMC7561410__F2 Signaling pathways in the epididymitis induced by UEPC TLR4 TLR5 TNF MYD88 PMC3692518__F4 miRNA Signature of Mouse Helper T Cell Hyper-Proliferation SPRY2 HRAS LAT PHLPP2 PAK1 CSK GRB2 SPRY1 LCK PMC8960951__F1 Role of Chronic Physical Exercise as a Treatment in the Development of Vitiligo CXCL9 CXCR3 IL10 APC FOXP3 CXCL10 IL1B PMC4016161__F1 The succinate dehydrogenase complex (SDH), as a member of the tricarboxylic acid cycle (TCA), catalyzes the oxidation of succinate to fumarate SDHD SDHA SDHB FES SDHC PMC12114673__F9 Schematic diagram illustrating the mechanism of CCNB1 in melanoma cells resisting NK cell-mediated cytotoxicity CDC2 IFNG STAT3 CD69 SMAD2 SMAD4 MICA MICB CCNB1 PMC3482366__F1 Summary of folate metabolic pathway DNMT3B MTRR MTR PMC7601352__F2 Screening of key genes related to the prognosis of mouse sepsis ZAP70 PARVB FERMT3 PKN1 TGFB1 ZYX PML PTPRC SH2D2A NCK2 SPI1 USP48 DOCK2 MDM4 STAT1 NFE2 TGFB1I1 OTUD7B TPM3 CNN2 SPATA13 ITK ZFPM1 OPTN YWHAG ACTG1 JUN IFNGR1 GATA1 ITGA4 KSR1 RPS27A ITGA2B FOS PREX1 tal-1 ACTN4 IKBKB UBE2E3 EPN1 CTNNA1 LCK PMC8350018__AF1 Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway IGF1 CDKN1A SSB TWIST1 CTNNB1 PMC12042419__F4 Schematic illustration of NOTCH3 signaling pathway involvement in the pathogenesis of CADASIL MAML1 ADAM10 ARHA RHO NOTCH3 RBPJ PMC3427155__F2 Analysis of Differential miRNA Expression in the Duodenum of Escherichia coli F18-Sensitive and -Resistant Weaned Piglets PTPRM STAG2 F11R CXCL12 PIK3CA CDC14B ABL2 EGFR NRP1 SMAD4 ATP2A2 PPP2CA PPP3CA LAMC1 CTSC IGF2R CNR1 PPARGC1A PDE4D VPS4B DCN CREB1 ACTG1 PDE7B ACVR2A ITGA4 PDE10A RBL2 LPAR1 SMC1A PLXNC1 EGLN2 AXIN2 NR3C1 GDF6 SEMA4D FGF7 CEBPA CBL SORT1 XB PDGFRA EDNRB PRKAB2 GNA13 PMC11640101__F4 Involvement of the ARF6-AMAP1 pathway and Arid5a in cancer progression and immune evasion RAB11B EPB41L5 ARID5A HEL-S-133P IDO1 MVP HK2 ARF6 HIF1A CCL2 KRAS PMC9485629__F1 Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression EGF TGFBI EGFR BMP7 PMC3351290__F10 TRPC1 channel is a major regulator of EGFR signaling CCND3 EGF STIM1 EGFR TRPC1 CCND1 PMC12038022__F2 Molecular mechanisms of ferroptosis and disulfidptosis SLC3A2 GPX4 LPCAT3 NUBPL FACL4 SLC7A11 NCKAP1 LRPPRC POR TFRC OXSM STEAP3 GYS1 RPN1 NDUFA2 PMC3748092__F8 Cell Surface Glycan Alterations in Epithelial Mesenchymal Transition Process of Huh7 Hepatocellular Carcinoma Cell GAL FUT8 FUCA1 B3GALT5 PMC11640101__F1 Metabolic reprogramming in cancer ACLY HMGCR HEL-S-133P MVP HK2 FASN PMC10473115__F1 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease TREM2 SYK DAP PMC10473115__F2 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease TREM2 SYK PLCG1 DAP PMC10473115__F3 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease TREM2 PLCG2 APOE PMC6468748__F1 Moonlighting functions of the endothelial protein C receptor (EPCR) APC PLG PC PMC9047859__F2 Functions of Stress-Induced Lipid Droplets in the Nervous System APOD FASN APOE PMC3489622__F2 Signaling networks induced in the spleen at 1 day post infection in wild-type mice (A) and STAT1 KO mice (B) PRLR ADAR IFITM2 STAT2 IRF9 PRKCZ IRF1 IRF3 IRF7 VEGFA GBP1 PTTG1 ARNT2 BAG3 IFNAR2 MX1 PSME2 OAS2 GBP2 PMC7705468__F1 Mechanisms involved in the tenocytes during the process of diabetic tendinopathy EGR1 SOX9 FOXO1 EBP HIF1A SCX PMC7705468__F2 Mechanisms involved in the tendon stem/progenitor cells during the process of diabetic tendinopathy SOX9 IGF1 BMP2 FPR1 ALOX15 MTOR SCX RUNX2 TNMD PMC10473115__F4 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease TREM2 SYK PLCG2 DAP PMC3382911__F1 Colon cancer cells produce immunoregulatory glucocorticoids EGF GC TNF PMC4178135__F3 Standardized pathway diagram calculated with a structural equation model of antepartal hormones in pluriparous dairy cows CFI PMC3202514__F1 Maturational changes in fatty acid and carbohydrate metabolism gene expression HEL-S-162eP PMC5086085__F5 Ecdysone receptor B1 (EcR‐B1) signaling to trigger pruning in MB G and da neurons HDC MB SOX14 VCP PMC6966863__F7 Mechanism for ABC transporters regulated by the level of PI3K 110A or 110B subunit TSC2 BAD PDK2 MTOR PMC8443474__F1 Aryl hydrocarbon receptor in liver inflammation CYP1A2 AIP AHR AHRR PMC8066875__F8 NFKB pathway and NLRP3 inflammasome activation and role of some microRNAs GSDMD NLRP3 IGF1 AMT AANAT IRAK1 MTOR TRAF6 IGF2 IRS1 IL1B PMC6722943__F9 Differentially expressed genes associated with the p53 signaling pathway CASP9 TSC2 ATR BAD PIGA PERP CDK2 ATM PTEN HEL-S-11 MDM2 MYC PMC7896869__F7 Involvement of SAB in enhancing proliferation and attenuating oxidative stress and apoptosis through activation of the JAK2/STAT3 signaling pathway STAT3 BAX PMC6659998__F3 FA/TAG metabolism in hepatocytes ACLY DGAT1 CD36 FABP1 FASN SLC25A20 FABP4 ACACA ACADM ACACB LIPC ACSL1 DGAT2 CIDEA PLIN1 CIDEC APOB ACADVL ADFP CPT1A CYP4A11 PMC11603636__F7 Schematic mechanisms concerning the IRE1Alpha-XBP1 axis in LPS-induced acute lung injury NLRP3 TXNIP XBP1 PMC8165189__F1 Hippo Signaling Pathway in Pancreas Development LATS1 CPA1 PDX1 SOX9 PTF1A PMC7981372__F5 Exploring the role of Azadirachta indica (neem) and its active compounds in the regulation of biological pathways: an update on molecular approach BAX PCNA BCL2 MMP9 PMC4219592__F1 Interactions between alcohol-induced mechanisms leading to hepatic carcinogenesis CYP2E1 C2 TLR4 PMC11759193__F7 Mechanistic overview scheme of the effects of aircraft noise on endothelial function KEAP1 CRH CD68 PMC5520851__F1 mTORC1 controls cell growth and is regulated by the lncRNA-encoded polypeptide SPAR RHEB TSC2 TSC1 ULK1 PTEN IRS1 OTP EIF4E PMC6711114__F1 The main enzyme pathways involved in mitochondrial pyrimidine dNTPs metabolism CDA TK1 DCTD PMC6596841__F1 Gpr17 signaling pathway following lysolecithin insult GPR17 OLIG2 XAF1 PMC4831565__F4 GAPDH nitrosylation pathway mediates cocaine effects SIAH1 HEL-S-162eP SUV39H1 PMC9130470__F3 NTRK Fusions in a Sarcomas Series: Pathology, Molecular and Clinical Aspects PTEN GRB2 PMC5177915__F8 Citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway TF ATF3 HEL-S-29 TLR4 PMC8165189__F2 Hippo Signaling Pathway in Pancreas Development LATS1 LATS2 ADM NFIB PMC3984774__F4 RB/E2F pathway MAX CCNE1 MYC SKP2 CDK4 PMC8123608__F3 Autoinflammatory Features in Gouty Arthritis SOCS1 APOC3 PPARGC1B NLRP3 TLR4 ANGPTL2 CD14 CNTN5 IL23R PGGT1B INSIG1 PMC7554785__F3 Reduced TCF1 expression promoting a differentiation bias of activated aged T cells toward terminal effector cells IL2RA MTOR BCL6 LEF1 RUNX3 PMC3889649__F5 GLI1 target genes converge on a regulatory pathway that suggests roles in cell proliferation, survival and genomic stability MAX FOXA1 RGS16 NTRK2 PRNP YY1 MYC PDE4B CTNNB1 TAF1 NR2A1 FYN PRPSAP1 E2F4 NPM1 GRB2 CREB1 MGMT PMC6306051__F7 Knockdown of nucleophosmin 1 suppresses proliferation of triple-negative breast cancer cells through activating CDH1/Skp2/p27kip1 pathway NPM1 SKP2 PMC8159873__F3 Cellular pathways involved in trained immunity CD40 NLRP3 CD36 APC IGF1R MTOR TRAF6 PMC125566__F1A Negative regulation of the Wnt–Beta-catenin pathway by the transcriptional repressor HBP1 APC CTNNB1 PMC3413017__F1 Apoptosis and necrosis BAX ATM MDM2 FADD PMC5645527__F1 WNT signaling pathway activation CD44 SOX9 APC GSK3B LRP5 LRP6 CTNNB1 PMC8851273__F9 Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling STAT3 PMC5948853__F8 A schematic of the model of crosstalk between STAT1 and TGFB signaling pathways SMAD4 JAK1 PMC9093150__F10 Working hypothesis of the role of the prostanoid pathway in angiogenesis inhibitor-induced hypertension and renal injury COX1 TET1 PMC3360095__F1 P2X4R-p38 MAPK is a core signaling pathway through which spinal microglia and peripheral macrophages contribute to neuropathic pain and inflammatory pain COX1 CCL21 BDNF PMC6147237__F1 A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity ADRBK1 BTK GSK3B ATF2 PMC7047255__F7 Pathway interaction schematic constructed to demonstrate overlap of gene expression data with critical osteogenic pathways BGLAP BMPR2 SMAD1 DKFZp781O1323 GSK3B SP7 RUNX2 SPP1 CTNNB1 PTCH1 MSC SMO MSX2 GLI3 PMC8847686__F10 Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder MAP3K7IP1 TRADD TRAF2 PMC6351482__F4 Mutation enrichment of Nectin adhesion pathway PTPRM CDC42 F11R PIK3CA VAV2 PIP5K1C IQGAP1 ITGB3 ITGAV RAC1 CTNNB1 CRK FARP2 RAPGEF1 RAP1A TLN1 SRC CTNNA1 CLDN1 PMC6095456__F1 Regulation of innate immune cell function by mTOR RHEB TSC2 RICTOR TSC1 RAB8A SGK1 FOXO1 PDPK1 HK2 AKT3 PTEN MTOR PMC10892755__F1 Cholesterol and isoprenoid synthesis pathway illustrating how statins inhibit the enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase CDC42 ARHA RAC1 PMC4568555__F1 Key transduction molecules of ErbB signaling pathway known to regulate cardiomyocyte viability and function BAX BAD FAS GRB2 MTOR PMC8182305__F2 Aquaporins in insulin resistance and diabetes: More than channels! AQP3 AQP7 AQP9 INS AQP11 PMC5715262__F3 Molecular pathways around CIC in cancer ATXN10 CIC DUX4 CCND2 ATXN1L CCND1 PMC4698395__F5 Mechanisms of stretch-induced reactive oxygen species (ROS) production and Ca2+ influx in dystrophic muscle CAV3 RYR1 SRC RAC1 PMC7896225__F1 Proposed neuroprotective role of Withaferin A (WA) in the modulation of pathways implicated in neurological abnormalities and dysfunctions.Parkinson’s disease (PD): WA is a known inhibitor of the Cdc37/Hsp90 complex LRRK2 CDC37 HEL-S-44 PMC5392045__F2 Interplay between autophagy, apoptosis, and the stimulator of interferon genes (STING) pathway TBK1 CGAS IRF3 PMC7144958__F1 XPF–ERCC1: Linchpin of DNA crosslink repair ERCC1 FAN1 SLX4 PMC4417466__F5 RPPA analysis in HeyA8-MDR treated with ZA STAT3 BAX BAD RAD51 MSH2 PXN EIF4EBP1 EGFR SP7 MYC YAP1 CTNNB1 RB1 CRK GRB7 RELA MMP2 ERBB2 APP GRB2 SRC GRB14 UNK PMC3376380__F1 mTOR signaling and its regulation by DGKs RHEB TSC2 RICTOR TSC1 MTOR PMC3841787__F5 Proposed signaling pathway model for VEGF-A signaling in hypoxia-stressed BM-EPCs compiled from the proteomic and gene expression analysis is highlighted here CASR NOS2 PIGF RHO VEGFA UNC13C PMC4446705__F1 The IL-4 and IL-13 receptor signaling pathways SOCS1 STAT3 IL13RA1 JAK3 PIAS1 ARG1 GRB2 JAK1 TYK2 IL13RA2 IRS1 PMC4687899__F2 Pancreatic Cancer Metabolism - Breaking it down to build it back up GLUD1 RPE GOT2 RPIA GLS HEL-S-133P HK2 GFPT1 HEL-S-32 ME1 PMC6322405__F1 Hippo signaling network and its biological functions OGT SLMAP SRC PMC5587470__F7 Diagram of muscle‐growth signaling pathway and differentially expressed genes, thus summarizing the effect of thermal gradient on muscle growth IGF1 IGF1R MTOR IGF2 PMC1180390__F5 Signaling pathways implicating p120-RasGAP SOS1 RAP1A CCM1 GRB2 SHE PMC9200993__F1 Treg Cell Metabolism and Function in Non-Lymphoid Tissues TFAM BATF IL33 STAT4 IRF4 GCK CTNNB1 GATA3 PMC2883511__F1 Signaling pathways and targets for LAM RHEB RHO MTOR EIF4E PMC6816394__F5 Role of tPA in the proliferative signaling and Wnt/Beta-catenin signaling GSK3B CCND1 CTNNB1 PMC7015009__F1 Hic-5-mediated signaling pathways for tumor progression ARHA MMP9 SRC PMC6637639__F1 Interaction network of proteins underexpressed in in vitro matured cumulus complexes (interaction confidence: high (> 0.7), database matches n = 82) SERPIND1 SERPINF2 ALPL TGFBI HEL111 ALB CFI GC A2M S100A13 C7 SERPING1 CES1 SERPINA3 PLG HRG TSG101 HEL-S-78p C4BPA EN1 FGA AKAP12 DIABLO CP TF PTX3 ENPP4 HEL-S-273 HSPG2 HEL-S-62p VTN GFPT1 Nucb2 APOH CLU F2 KRT73 C4B_2 HBB KNG1 ITIH2 SERPINC1 A1BG ANXA4 AMBP CFH COPA CLEC3B HBA2 APOA2 FTH1 IGLL5 HPR GUGU MGAM AP1B1 GJA1 PMC6443908__F7 APR signaling pathway is associated with ozone exposure and bacterial infection AHSG TCF3 APOH AMBP HAMP TCF4 PMC7767264__F4 Representation of genes/pathways/transcription factors identified from host–pathogen interaction during aflatoxin production MYB ERF PMC6637639__F2 Interaction network of proteins overexpressed in in vitro matured cumulus complexes (interaction confidence: high (> 0.7), database matches n = 116) ARHGAP1 ACSL3 RCC2 SRM SRGAP1 ACADVL CACYBP HEL-S-114 MTHFD2 ACOT7 ELAC2 REXO2 KCTD14 MMP19 CRYM RPL31 TRAPPC3 CAPZA2 SCD TBCD BTF3 PUF60 SET BCCIP CHD4 GNA14 DDB1 SFRP4 MVD PSAP NUP210 SETD7 ATXN10 EGFR PTK7 DPYSL3 ACACA KPNA2 RPS10 CCND2 DHRS9 UMPS PFKM OAS2 CRELD2 FASN HSPBP1 CTH EIF6 HEL-S-70p CMBL CD200 PFAS FLRT2 XPOT MAGED2 PMC8664701__F2 Nutritional therapy can reduce the burden of depression management in low income countries: A review CRH TNF PMC7726231__F3 Raptor silencing down-regulated components of mTORC1 (RPTOR, RPS15 A, RPS28) but not mTORC2 signaling in PHT cells RHEB TSC2 EIF4B TSC1 INSR ULK1 PC RHO MTOR ELF3 EIF4E PMC9200993__F2 Treg Cell Metabolism and Function in Non-Lymphoid Tissues TFAM HMGCR CD36 GPX4 GCLC IFNA4 FOXP3 MTOR SIRT1 PMC7817101__F8 Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKA stability via selective autophagy NBR1 SUMO2 ANXA1 PMC10487928__F5 Delta interactome of the top 20 most connected differentially expressed genes (DEGs), defense response to virus genes, angiogenesis genes, adaptive and innate immune genes, and SARS-CoV-2 proteins TRIM14 RIOK3 IFIT1 IFIT3 PML KIF20A IFIT2 DHX58 PLK1 EPHB2 OASL MX1 ISG15 F2RL1 OAS1 APOBEC3B CIT EPHB4 GBP3 CDC2 PARP10 FBXO6 H4C9 RAD51 HIST1H2AB PARP14 TRIM34 CTSL IRF7 PTGS2 GBP1 BNIP3L OAS3 LAMP3 H2BC3 C4BPA CDC45 HEL-S-102 TRIM6 PMC6135718__F6 Potential lymphangiogenesis therapies: learning from current anti-angiogenesis therapies - A review EGFR ERBB2 MTOR PMC4523862__F8 USP18 negatively regulates NFKB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms MAP3K7IP1 TAB3 USP18 TRAF6 MYD88 PMC11121022__F1 Systemic sclerosis, recognized as a prototypical autoimmune disease, is intricately governed by a myriad of autoimmune mechanisms IL12A APC TYK2 HLA-DQB1 TNLG2B PMC4173667__F7 Schematic representation of a possible inflammatory pathway CD44 MYD88 PMC6813799__F1 Key Steps of Reverse Cholesterol Transport ABCG1 ABCB11 LDLR PLTP PMC8980436__F3 Cancer Metabolism: The Role of Immune Cells Epigenetic Alteration in Tumorigenesis, Progression, and Metastasis of Glioma STAT3 EGFR SOX2 GSK3B MTOR PMC8217759__F7 M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13RA2/MAPK Pathway in Rat Intervertebral Disc Degeneration CHI3L1 MMP3 MMP9 IL13RA2 PMC11754067__F1 Structure and formation mechanism of KL-la, KD-la and Kce HDAC3 HEL-S-133P GLO1 SIRT2 PMC8063606__F2 Pack a STRIPAK with hubs inside a hub LATS1 LATS2 YAP1 PMC8326263__F3 Gastrointestinal and hepatic diseases during the COVID-19 pandemic: Manifestations, mechanism and management VWF CCL25 IL17A MTOR PMC5388549__F9 Proposed mechanism for the effect of FPS-ZM1 in COPD HMGB1 S100A6 PMC8417791__F1 An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update ACE2 PMC4107617__F3 Group I mGluR-signaling pathway in immune cells JUN FOS IL1B PMC6887802__F2 COPD and autophagy pathway GAL EGR1 ATG3 ULK1 ATG14 MTOR PMC5828319__F4 CD200R-induced signaling pathway STAT1 SRC PMC5828319__F2 Inhibition mechanism of IL-12 production through interaction of TIM-3 and Gal-9 TEC STAT3 STAT1 TLR4 SRC TRAF6 IRAK4 MYD88 PMC6829368__F9 Network of the glutathione metabolism pathway RRM1 SRM GCLC C7orf24 OPLAH HEL-S-64p PMC6144915__F2 Pathway-pathway crosstalk via GADD45B CDK6 PCNA SMAD4 GADD45B CDK4 PMC9550190__F1 Conducive target range of breast cancer: Hypoxic tumor microenvironment STAT3 CXCL12 HEL-S-133P IL16 EGFR BNIP3 SIRPA ARG1 CCL5 MTOR CCL2 CD47 PMC9550190__F2 Conducive target range of breast cancer: Hypoxic tumor microenvironment STAT3 CXCL12 EGFR CXCR5 FOXP3 CXCR4 PMC7773221__F2 Common regulatory proteins of the complement and coagulation systems MASP1 MASP2 C1S APC C1R C4B_2 PMC9266536__F1 Fenretinide in Cancer and Neurological Disease: A Two-Face Janus Molecule RARB ELF2 PDK2 PMC7024175__F1 CAMKK2 signaling pathway CAMK1 CAMKK2 CAMK4 PMC6639181__F9 Summary scheme represents the possible pathways of drug sensitive and drug resistance to cordycepin in MA‐10 mouse Leydig tumor cells ATF3 ATF4 MTOR EIF2A XBP1 CDK4 PMC4848973__F5 Matrix Hyaluronan Promotes Specific MicroRNA Upregulation Leading to Drug Resistance and Tumor Progression HOXD10 CD44 BCL2 ARHA PMC8268881__F4 Intraductal Papillary Mucinous Carcinoma Versus Conventional Pancreatic Ductal Adenocarcinoma: A Comprehensive Review of Clinical-Pathological Features, Outcomes, and Molecular Insights GNAS CDX2 CDKN2A RNF43 SMAD4 PTEN KRAS PMC3479319__F1 Wnt signaling cascadesWnt signals can be transduced either through the canonical pathway (colored in pink) or different non-canonical pathways JUN APC RHO MTOR CTNNB1 PMC6887802__F3 Lung cancer and autophagy pathway ULK1 MTOR PMC4991494__F6 Quantification of mutant alleles in circulating tumor DNA can predict survival in lung cancer INHBA PRKDC CREBBP SMAD4 ATM PMC6887802__F4 Infectious lung disease and autophagy pathway IFNG ULK1 AMBRA1 ATG14 MTOR TRAF6 PMC6887802__F6 Pulmonary arterial hypertension and autophagy pathway ULK1 MTOR ATG5 PMC6963221__F1 Sensing of Dengue virus by the innate immune responses and multiple evasion strategies to hinder the production of type I interferons (IFN).The upper panel shows the sensing of viral infection by RIG-I and cGAS TBK1 CGAS MAVS XRN1 TRIM25 IKBKE IFNAR1 PMC7708667__F1 Biglycan determines pro- and anti-inflammatory signaling response by switching between TLR2/TLR4/CD14 and TLR4/CD44 CD44 CXCL13 NLRP3 TLR4 IL18 CD14 MYD88 PMC6887802__F7 Acute lung injury and autophagy pathway ULK1 MTOR PMC8082393__F8 Comprehensive RNA-Seq Analysis of Potential Therapeutic Targets of Gan–Dou–Fu–Mu Decoction for Treatment of Wilson Disease Using a Toxic Milk Mouse Model LPL UBC HEL-S-28 PLTP SHE CPT2 PMC6498606__F7 Model of PAPP-A-driven PABC IGFBP5 LARP6 DDR2 PMC9359464__F4 Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host TLR1 TLR4 TLR9 TLR8 TLR5 TLR7 TRAF6 MYD88 PMC10418609__F8 Expression of the DBNDD1 signaling pathway in prostate cancer (MetaCore) FRAT1 NGF BAD APC FGFR1 GRB2 HTR2A CREB1 RAC1 IRS1 FGF2 PMC4779130__F2 Signals involved in early granuloma formation CXCL11 CXCR3 MMP9 PMC9359464__F3 Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host TNFRSF8 PTPA GADD45A PMC5603903__F8 Schematic diagram summarizing factors influencing the signaling efficacy of the TLR2/1-VDR pathway in response to TLR2/1 elicitation NR1i1 DBP TIRAP CSK PTH PMC7605288__F1 Caudal-related homeobox transcription factor 2 plays different roles in embryo, intestinal epithelium and colorectal cancers CDX2 APC GSK3B CDK2 ATM MTOR AXIN2 CTNNB1 PMC4605623__F10 The Fanconi Anemia C Protein Binds to and Regulates Stathmin-1 Phosphorylation CDC2 CAMK4 FANCC PMC9678611__F4 Prediction of network pharmacology and molecular docking-based strategy to determine potential pharmacological mechanism of Liuwei Dihuang pill against tinnitus TF TFRC HEL-S-133P C2 TLR4 NOG EPO F11 HEL-S-87p DAO VHL PMC7429716__F1 G2/M checkpoint signaling pathway CDC2 ATR WEE1 CDK2 PMC4301714__F1 Simplified model of the Rag4-KlRgt1 glucose signaling pathway controlling RAG1 gene expression ENO2 XK RAG1 ENO1 PMC3465335__F4 Temperature Dependent Proteomic Analysis of Thermotoga maritima HEL-S-162eP PMM1 PMC4345858__F9 Acsl1‐dependent changes in metabolites in the biochemical pathway involving cysteine and glutathione metabolism CHAC1 pcap PMC12067746__F7 Graphical illustration of the working model INHBA SMAD4 FOXP3 PMC5464940__F1 MOA of CHST15/CS-E and STNM01 in tissue remodeling in IBD CCL2 CTNNB1 PMC7818425__F6 Selected features and functions GLIS3 PTPN22 IL10 CTSH SUMO4 PHTF1 SCAP2 IL2RA IL7R PMC538777__F7 Novel Jun-Dmp1 pathway DMP1 MDM2 MYC CCND1 CDK4 PMC5419568__F5 Blocking Smad2 signalling with loganin attenuates SW10 cell cycle arrest induced by TNFA CDK6 SMAD2 CDK2 CDK4 FADD PMC8997587__F11 Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders PTBP1 BDNF HEL-S-30 PMC6628899__F1 Ipilimumab in prostate cancer APC CTLA4 PMC10420159__F1 Immune checkpoints in a tumor microenvironment (TME) HEL-S-92n CD80 HHLA2 LAG3 PMC3090458__F3 BAFF and APRIL signaling pathways in B cells MAP3K7IP1 TLR4 TRAF5 TLR9 TLR8 TLR7 TRAF3 TRAF6 TRAF2 MYD88 PMC6721552__F3 Simplified overview of the MAPK and PI3K pathway TSC2 TSC1 NF1 PTEN MTOR PMC3108097__F1 Iron Homeostasis and the Inflammatory Response TF TFR2 TWSG1 EBP GDF15 HFE XBP1 HFE2 PMC6332843__F2 PD-1 signaling in B cells and T cells ZAP70 SYK BCR PLCG2 CD36 PMC7175146__F2 Structure of the neurovascular unit (NVU) with particular attention to the glucose metabolism impairment AQP4 S100B PMC8958553__F1 AKI and CKD affect FGF23 via inflammatory, iron deficiency, anemia, and metabolic related pathways LPA STAT3 ORAI1 IGF1 FOXO1 EPO IL6 LCN2 MTOR FGF23 PMC3995856__F4 Pathway analysis and molecular interactions of focus genes AKT, CTNNB1, GAB2, and SERPINE1 (hightlighted in pink) PFKFB1 INPP4B UXS1 DOCK6 ACAP1 CNKSR1 MST1R HSPB8 PTPN13 GAB2 YAP1 CTNNB1 PMC7465203__F1 The Wnt pathway APC LRP5 LRP6 CTNNB1 PMC11816803__F9 Figure illustrates simplified pathways involved in the development and progression of EC based on KEGG BRITE data (BRITE accession ID: K04503, pathway map ID: map05213) BAX CASP9 BAD POLK APC HEL-S-28 PTEN GRB2 CTNNB1 PMC4292165__F1 Signaling pathway of cell surface TLRs TBK1 TIRAP TMED7 CD36 TAB3 TANK CD14 IRAK2 IL1A TRAF3 IRAK4 MYD88 NLRX1 TLR1 TLR4 IL1B PMC4292165__F2 Signaling pathway of endosomal TLRs TBK1 TLR9 IRAK1 IRF7 IL6 TRAF3 TNF TRAF6 IRAK4 MYD88 TLR3 TLR8 TLR7 PMC4322524__F1 Signalling pathways that control maintenance of BCSCsWnt binds its co-receptors: Frizzled (Fz) and LRP5/LRP6 APC GSK3B LRP5 SHH LRP6 CTNNB1 PMC6326667__F5 Environmental enrichment largely prevented age-SNCA-dependent disturbances and activated topologically relevant genes in the SNCA interactome with respect to both disturbance modes NDUFB6 HIVEP1 RAF1 RFXANK SPARC CTSS C1QB SMARCD1 NDUFA13 NDUFAB1 MAOA ADRBK1 CD9 HEL-S-5 CRY2 NPAS2 TPT1 MEGF11 SERPING1 CTSL HSD17B10 RPH3A BRSK1 SNCA LRRC47 KCNF1 CDK2AP1 BHLHB2 CNTFR PREX1 PGAM2 GFAP EIF3E COL18A1 RXRA AIF1 NDUFAF1 BHLHE41 HEL113 MMP14 ITGB4 NDUFA6 INS UQCRQ Nucb2 CRTC1 MERTK MYLK PER3 HIPK2 LYRM4 CCND2 SLC18A2 UNC5B GADD45B ATM C4B_2 MCTS1 CIC EGR1 HEL-S-67p PER2 CRY1 BLNK ID3 TG ARHGDIB PHGDH C1QA FCER1G CASP3 PMC5354927__F1 Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism and clinical implication REST CCL21 PMC5354927__F2 Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism and clinical implication HDAC3 PMC4292165__F3 RLR Signaling pathway TBK1 RNF125 TRIM25 USP4 TRAF3 CYLD PMC9250200__F2 Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis CDH2 WNT3 ASNS MTOR FAAH AQP8 PMC9250200__F3 Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis NRG1 GDNF BMP4 NRG3 BOK AMH MTOR FGF2 PMC9250200__F1 Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis GC MTOR FSHR PMC9405571__F3 Multifaceted Roles of Autophagy in Infectious, Obstructive, and Malignant Airway Diseases HMGB1 NLRP3 ATG12 TFEB CFTR PARK2 MTOR SIRT6 PMC10527326__F2 The Biomarkers, Molecular Targets and Mechanisms of Non-Alcoholic Steatohepatitis-Driven Hepatocarcinogenesis HEL-S-20 KEAP1 CNPY2 MITA IRS1 CTNNB1 PMC8786701__F3 Impact of DNA testing on management of patients with colorectal cancer EGF EGFR PTEN MTOR PMC4697456__F1 CAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis NRG1 PRF1 CIRSR GPR4 PMC8698706__F10 Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid STAG2 CDC20 PCNA STAG1 SMAD2 SMC3 SMAD4 MYT1 SKP2 ORC2 CDK7 CDC45 MCM3 CDK2 MCM2 PMC4413232__F10 Sonic Hedgehog signaling maintains proliferation/self-renewal of cerebellar progenitor cells PRC1 SHH PMC12073286__F8 Schematic diagram indicating how SP protects ALD mice via the multi-target regulation of the CYP2E1/Keap1/NFKB signaling pathway CYP2E1 KEAP1 PMC3720830__F7 Cytochrome P450 1A1 Regulates Breast Cancer Cell Proliferation and Survival RHEB TSC2 TSC1 MTOR PMC5085755__F3 Functions of three members of the UBXD protein family (UBXN1, P47, and FAF1) that are potentially involved in the prevention of cancer TRADD FAF1 UBXN1 TRAF2 PMC10492287__F9 The metabolic pathway in placental cells GOT2 PFKP HK2 LAT2 PMC6098897__F2 Schematic diagram for the activation of BMPs, Wnt, and MAPK pathways by phytochemicals treatment MSC SMAD4 RUNX2 CTNNB1 PMC4114922__F5 Function and regulation of the Rho guanine nucleotide exchange factor Trio TRIO ETS2 ARHG TBX3 VCAM1 RAC1 CDH15 PMC4114922__F6 Function and regulation of the Rho guanine nucleotide exchange factor Trio TRIO ARHA RAC1 PMC2556866__F1 Telomere structure and DSB processing RAD52 ATR RAD51 PMC4114922__F4 Function and regulation of the Rho guanine nucleotide exchange factor Trio DCC TRIO FYN RAC1 PMC4346946__F4 Regulatory mechanisms of actin dynamics in response to DNA damage LIMK2 JMY RHO PMC8983706__F1 High-throughput translational profiling with riboPLATE-seq RPS6 TSC2 TSC1 MTOR EIF4E PMC4346946__F3 DNA damage-induced molecular responses for DNA repair BRCA1 H2AX ATM ATF2 MDC1 PMC6330548__F2 The proposed genetic interactive network among genetic factors in lignin biosynthesis pathway, which exemplified by S‐lignin biosynthesis RAN CAD PMC9283012__F3 Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 and Its Related Molecules as Potential Biomarkers in Small-Cell Lung Cancer RAB7A MAP3K12 EVI1 BNIP3 RAB33B MAP3K2 EZR TP53INP2 CAMKK2 FYN ADRA2A ADRA2B VAV3 SEMA6B LRP6 TNF PIP4K2B EDNRA DIAPH2 EDNRB WASF2 BDNF RGS2 TH PPIF MTMR3 CACNA2D2 DDIT4 WASL RELB PPP2CA RYK MEF2C ROBO2 TGFBR2 PRKCE RASA2 F2 FGF9 EPHA3 ULK2 CFL2 EPHB4 ITGA4 SLC8A1 EPHA4 ARHA LAMP2 PDE3B ATP1B3 SEMA3A ADRA2C DDIT3 FGF20 CACNB4 RPS6KA3 PMC8616433__F4 Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy HMGB1 C2 EGFR PMC10527059__F8 Presenilin-1-Derived Circular RNAs: Neglected Epigenetic Regulators with Various Functions in Alzheimer’s Disease PRDM9 PPARG BRD4 E2F4 SMAD2 NRARP EP300 CBX3 GATA4 HES1 HES5 TGFBR1 PMC6830879__F4 Schematic diagram showing the major regulatory growth factors released by exosomes and the changes in tendon that occur aiding the healing process WNT5B ANGPTL4 SMAD2 SPHK1 MTOR PMC8233804__F1 Is Vitamin D Deficiency Related to Increased Cancer Risk in Patients with Type 2 Diabetes Mellitus? CYP27B1 CYP24A1 CYP11A1 CYP27A1 PMC11116266__F2 JAK STAT signaling proteins in spondyloarthropathy and possible mechanisms of action of the JAK inhibitors IFNG EPO TPO PMC9117624__F3 Association Between Neddylation and Immune Response TBK1 CGAS RIGI MAVS IRF3 IRF7 TRAF3 TRAF6 MYD88 PMC3892798__F1 PD-1 in T-cell activation, exhaustion, and effector function CD80 APC PMC6323445__F3 FGFR1/FGF21/BKlotho complex actions in the cardiomyocytes BAD UCP3 FGF21 FGFR1 PMC10527059__F4 Predicted function of miRNAs interacting with circPSEN1s is summarized in this picture ID2 SMAD2 SMAD4 BACE2 WTIP TGFBR1 ID3 RNF157 PTMAP7 GJD3 LATS2 MRPS15 E2F4 INCENP ID4 PMC3774138__F1 Role of mTOR Inhibition in Preventing Resistance and Restoring Sensitivity to Hormone-Targeted and HER2-Targeted Therapies in Breast Cancer RHEB EEF2K TSC2 BAD MAP4K3 TSC1 PTEN IRS1 EIF4E PMC4685736__F1 Tissue‐specific function of Blimp‐1 expression in dendritic cells IL16 GC NOD2 IRF4 PMC7522539__F4 Mood stabilizers and mt protein or pathway targets, as well as the schematic of precision psychiatry medicine PPARG HEL113 LEP GLS TNFRSF1A GSK3B PPP3CA MTOR FAAH DAO MAPK14 GNB1 RPS10 HSPD1 FYN IMPA2 CLU PRKCA SLC25A1 HNRNPK HDAC2 JUN LRRK2 RPL11 TNF TUBB OMD UQCRC1 SDHA HEL-S-71 DAOA GSK3A NFKB1 DBI CASP3 HSPA4 BCL2 PFKL RASD2 JARID2 NDUFS1 BIK YWHAZ PMC3774138__F2 Role of mTOR Inhibition in Preventing Resistance and Restoring Sensitivity to Hormone-Targeted and HER2-Targeted Therapies in Breast Cancer RHEB TSC2 BAD TSC1 PTEN GRB2 EIF4E PMC7522539__F1 Conceptual systems framework in NPDs (BD/SZ/MD), and lithium treatment amelioration of mitochondrial (mt) functions in distinct pathways MARCKS BDNF CTNNB1 PMC2654975__F1 Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease DTX1 HEY2 DTX2 ITCH POFUT2 NUMB DNM3 POFUT1 PSEN1 PSENEN FBXW7 MAML3 MSI1 ADAM17 APH1B MIB2 MSI2 AP2A2 JAG2 LFNG DLL3 MAML2 HES1 HES5 LAG3 SPEN HES2 SIAH1 MIB1 DLL4 HES6 FURIN NCOR2 NEURL2 MAML1 NEDD4 PSEN2 ADAM10 PMC3044403__F1 The GlcNAc and GalNAc salvage and O-GlcNAc signaling pathways OGA OGT NAGK GALK2 PMC3680934__F1 Activation of TAZ upon epithelial-to-mesenchymal transition in human breast cancer cells LATS1 CD44 LATS2 NF2 PMC4026397__F2 Role of NADPH Oxidases in Liver Fibrosis NOXA1 PTEN PMC2715000__F8 Summary of caspase 2-mediated signaling cascades in heat-induced germ cell apoptosis MAPK14 BAX NOS2 GEM BCL2 PMC8345975__F1 Cardiomyocyte Proliferation as a Source of New Myocyte Development in the Adult Heart CDC2 MOB2 ERBB4 LATS1 NRG1 LATS2 CDK6 CDK5 PDK4 ERBB2 CDK2 CDK3 CDK4 PMC5900062__F1 Canonical and non-canonical NFKB signaling pathways LEP CARD11 RELB OTULIN TAB3 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 BCL10 BCR PLCG2 NFKB1 TRAF2 CYLD PMC4810982__F1 Proposed scheme for the protective effects of linagliptin against ABeta-induced neuronal insulin signaling blockade.GLP-1 is synthesized and secreted by neuronal cells DPP4 GSK3B SIRT1 PMC3296242__F8 Models of interactions within the destruction complex (A) and the catalytic cycle of the destruction complex (B) APC APC2 CTNNB1 PMC4026397__F4 Role of NADPH Oxidases in Liver Fibrosis BAMBI TIRAP TLR4 SMAD2 SMAD4 IRAK1 IRAK2 TRAF6 NOX4 IRAK4 IL1B MYD88 PMC4275033__F1 Metabolic pathways that lead to the production of fatty acids and fatty acid-derived chemicals tmp_locus_29 AHR FADD PMC5342869__F1 Regulation of the Hippo-YAP pathway by extracellular biophysical cues LATS1 GAA LATS2 SLC38A1 SLC7A5 RHO PMC2997573__F1 The current understanding of PELP1 signaling pathway PELP1 EGF SF1 EGFR SRC PMC4346946__F1 Nuclear entry of Cofilin-1 (CFL-1) via various stresses LIMK2 LIMK1 INO80 PMC6160231__F3 Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase WNK1 FYN c-fgr LYN SRC LCK CTNNB1 PMC4226441__F2 Targeting the estrogen pathway for the treatment and prevention of lung cancer HBEGF TGFA EGFR GRB2 SRC PMC11945810__F1 Possible mechanism underlying hepatotoxicity PAH CS TNF PMC4553092__F1 The roles of various key members of the LRP receptor family; LRP4, LRP5, LRP6 and LRP8 in bone related traits and bone mass regulation LRP4 LRP8 DKK1 LRP5 KREMEN1 LRP6 PMC11945810__F2 Illustration of cell crosstalk and molecular pathways of different chemicals in the liver microenvironment AHR PAH PMC10041467__F1 Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer’s Disease BAAT CYP7A1 CYP27A1 AMACR PMC4962009__F1 Replicative aging cooperates with other aging mechanisms to activate the p53 and/or Rb signaling pathways CDC2 ATR CDK6 CDK2 ATM CDK4 PMC8446424__F2 TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy TREM2 SYK MTOR CTNNB1 PMC7202281__F5 Interaction network of differentially expressed proteins between patients with pancreatic cancer and healthy controls, assessed by the Ingenuity Pathway Analysis software ENG TGFB1 FLT4 VGF IGLL1 S100A6 IGFBP4 ATM TUBA1B APAF1 TOP2A LBR PMC2721821__F6 Graphical representation of the Hh signaling pathway in its activated state and possible sites of HPI action SUFU PTCH1 SHH SMO PMC3205612__F1 Interplay between autophagy and intracellular pathogens IFNG VASP MVP ULK1 ATG14 MTOR ULK2 PMC10346484__F2 Key metabolic pathways for the biosynthesis of NEAAs, the enzymes in each pathway, and the main functions of each AA [54,173] GOT2 GPT2 MTOR HEL-S-51e ADI1 VPS29 GLUD1 PIG59 SHMT1 BHMT2 PAH HEL-S-61p ASNS AGA GLS2 MTR PYCR2 PSPH GPT PMC7568652__F3 CD40 pathway genes upregulated (red) or downregulated (green) by exposure of primary human keratinocytes to TSST-1 (100 μg/ml) or SEB (100 μg/ml) in triplicate assays for 6 h exposure time CD40 TRAF5 TANK ATF1 TRAF1 TRAF3 TRAF6 PMC7568652__F4 CNTF pathway genes upregulated (red) or downregulated (green) by exposure of primary human keratinocytes to TSST-1 (100 μg/ml) or SEB (100 μg/ml) in triplicate assays for 6 h exposure time CNTFR CNTF GRB2 MTOR PMC7553775__F7 Coordinated repression of A3B transcription by both E2F4/DREAM and E2F6/PRC1.6 complexes TFDP1 RBL2 MGA RBL1 L3MBTL2 LIN54 LIN37 RBBP4 E2F4 LIN52 E2F6 RYBP YAF2 LIN9 TFDP2 PCGF6 PMC10296091__F1 A2AR effects in microglia, astrocytes, and synapses under physiological conditions BDNF PMC10751873__F2 High expression level of CRNDE contributes to CRC by upregulating the signaling pathways such as Ras/MAPK, Wnt/Beta-catenin DUSP5 ATAD2 TCF7L2 CDKN1A HNRNPUL2 EZH2 CTNNB1 PMC9523377__F3 Multifunctionality of Calebin A in inflammation, chronic diseases and cancer STAT3 CXCR4 TNF PMC6101248__F6 BPS-induced placental dysfunction working model GCM1 HYAL2 PMC6928850__F1 Molecular Characterization of XX Maleness SIX4 IGF1R SOX10 CTNNB1 POR DMRT1 WT1 EMX2 FOXL2 SOX9 SRY INSR FST FGF9 WNT4 AMH SOX13 STAR SIX1 TCF21 RSPO1 LHX9 SF1 C2 SOX3 DHCR7 AMHR2 GATA4 SOX8 PMC8534102__F3 Mental Illness and Amyloid: A Scoping Review of Scientific Evidence over the Last 10 Years (2011 to 2021) BACE1 APP PMC4814919__F9 Beta-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H APOA4 FGF21 PMC3310155__F1 Model of CaS receptor sorting traffic CASR RAMP3 RAMP1 PMC6617847__F5 Schematic outline of the salinity-induced response pathway based on proteome, gene expression, and physiological changes in chickpea leaves MYB MYC AVP PMC10751873__F4 CRNDE: A Pivotal Oncogenic Long Non-Coding RNA in Cancers CDK6 CCNE1 CCNB1 CDK4 CTNNB1 PMC10751873__F5 CRNDE: A Pivotal Oncogenic Long Non-Coding RNA in Cancers E2F3 RAP1A SRSF6 PICALM PMC4918703__F1 The podocyte and the glomerular filtration barrier (GFB) MYO1E HEL-S-47e INF2 ACTN4 CD2AP MYH9 GRB2 TRPC6 ARHGAP24 PMC8151307__F10 Quo vadis Cardiac Glycoside Research? EGFR GRB2 SRC PMC7023272__F2 Resveratrol (RES) crosses the blood‒brain barrier via tight junctions STAT3 MTOR MGMT PMC3526508__F2 Becoming a follicular or a MZ B-cell? BTK BCR NOTCH2 PMC6429457__F4 Upstream regulator analysis of the differential proteome of the spleen from 11-week Npc1−/− mice GUSB TCL1A HEL-S-130P GPNMB MPEG1 C1QC MMP9 SNX6 PMC6451240__F1 Phagocytic pathway in glial cells TREM2 RAB10 VPS35 XCR1 SYT11 AXL LRRK2 CX3CR1 MEGF10 TLR4 CD33 CR1 PMC4167320__F1 Overview of the extrinsic, intrinsic, and phagocytosis-induced apoptotic pathways CASP9 PCNA CASP3 PMC8072665__F4 Identification of the Key Role of NFKB Signaling Pathway in the Treatment of Osteoarthritis With Bushen Zhuangjin Decoction, a Verification Based on Network Pharmacology Approach PPARG SLC2A4 PCOLCE HIF1A CCNA2 MYC MAPK14 ALB HMOX1 BCL2L1 PTGS1 THBD MMP2 ALOX12 CD163 GSTM2 APOD SLPI MMP10 IRF1 VEGFA CXCL10 FOS CXCL11 TP63 ADRB2 CDK2 HEL-75 GRIA2 NOX5 MAP2 RUNX2 MPO PRKCB ABAT PLAT COL1A1 F3 CHUK CTRB1 ABCG2 CCND1 BAX E2F2 SELE FASN CD14 CXCL2 NFATC1 SPP1 MGAM AHSA1 LBP PMC8072665__F5 Identification of the Key Role of NFKB Signaling Pathway in the Treatment of Osteoarthritis With Bushen Zhuangjin Decoction, a Verification Based on Network Pharmacology Approach FUS EED SIRT7 RPS14 FBL RPL38 C1QB HIF1A MYC FLNA RPS11 BMI1 RPS8 RB1 RPS3A TRIM28 RPA3 NOP56 NPM1 MDM2 MAPK1 LIMA1 RPL31 SP1 HSPA14 RPS19 EZH2 ILF3 RPL23 TUBB RPL13 MAGOH RPS7 SET BRCA1 PAK1 EEF2 CDK2 SNW1 MCM2 GRB2 NCL SNRPA1 LMNA PCNA TUFM PML HEL-S-100n VCP RPS27 PAN2 RPS3 F2 MYH9 APP CLTC HEL2 YWHAG CDC2 UBC JUN RPS2 YBX1 HEL-S-30 RPA1 RPL6 VHL HEL-S-162eP PRKDC RELA RUVBL2 CREBBP EP300 AHSA1 CDC37 RPS9 PS1TP5BP1 KAT2B KAT2A PMC3545710__F5 Suggested pathway STAT3 PIM1 NFATC1 PMC6226322__F7 ZFPM2-AS1, a Novel lncRNA, Attenuates the p53 Pathway and Promotes Gastric Carcinogenesis by Stabilizing MIF BAX MIF PMC6928850__F2 Testicular and ovotesticular differentiation in XX foetuses SOX10 RSPO1 DMRT1 WT1 SF1 FOXL2 SOX9 SRY FGF9 SOX3 WNT4 AMHR2 AMH PMC9094073__F1 Targeting mTOR and eIF4E: a feasible scenario in ovarian cancer therapy RHEB TSC2 TSC1 PMC6387020__F6 Representative liver disease pathway MAPK1 CASP9 BAD TRADD KEAP1 EGFR CASP12 GSK3B MMP9 MTOR TNF MAPK3 NFKB1 RELA RXRA CASP3 NFE2L2 BCL2 GRB2 TRAF2 PMC7564998__F1 Oxidative stress, mitochondrial dysfunction, axonal transport, and glutamate excitotoxicity in amyotrophic lateral sclerosis (ALS) FUS SETX VAPB ATXN2 OPTN VCP NEFH PMC6387020__F5 Representative cardiovascular disease pathway CDC42 MAPK1 MAPK14 CASP9 BAD CACNA1C HEL-S-102 PRKCA PTGS1 PTGS2 SRC MAPK3 PMC8922476__F3 Gut-brain axis of CCM disease KLF4 KLF2 TLR4 PDCD10 PMC3408345__F6 Glucocorticoid (GC) actions in the airways epithelium STAT1 STAT2 IRF9 RXRA IRF3 IRF7 PPARGC1A PMC1199368__F5 Candidate genes that are involved with the metabolism of androgen and estrogen HEL-S-22 UGT2B15 LHB SHBG NR3A2 CYP11A1 HSD3B1 HSD17B1 STS PMC2885703__F11 WNT1-Inducible Signaling Pathway Protein-1 Activates Diverse Cell Survival Pathways and Blocks Doxorubicin-induced Cardiomyocyte Death BAX GSK3B PTEN CTNNB1 PMC4017675__F5 In sum, there is a critical clinical need for better understanding and treatment of inflammatory airway disease in general, and mucous cell metaplasia in particular MUC5AC MUC5B MUC19 PMC2896964__F1 Schematic representation of the possible interactions between HIV-1 and the host miRNA-guided RNA silencing pathway DGCR8 AGO2 DROSHA PMC3830884__F4 MAP kinase signaling pathway of sugarcane infected by S CDC42 GLO1 PMC11999627__F2 IL-33/ST2 signaling pathway IL1R1 TAB3 IL33 SIGIRR IRAK1 TRAF6 MYD88 PMC6482944__F2 Molecular regulation of PFGA in Mice CXCL12 GDNF LIF BMP7 KIT PTEN MTOR RHEB TSC2 TSC1 IL16 BMP4 KL AMH GDF9 PMC5938816__F11 Gene expression pattern related to TLR4 signaling pathway following epileptic seizure IL10 TLR4 IRF3 MYD88 PMC3797650__F1 Diagram of hedgehog (Hh) signaling in mammalian cells STAT3 EGF ITCH BOC NRP1 GPC3 BMI1 ADRBK1 SAG KIF7 SUFU BCL2 SMO RAB23 MDM2 ABCG2 CCND1 WIF1 PMC3959213__F6 Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway HEL-S-162eP ENO1 HEL-S-87p PMC11545656__F1 Scheme of CD95 pathway BAX APAF1 FADD PMC4581331__F4 Biological mechanisms of MALAT1 in CRC SFPQ CTNNB1 PMC11545656__F2 Scheme of CD95-mediated apoptotic and non-apoptotic signaling RIPK1 TRAF2 FADD PMC3959213__F1 Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway HEL107 HEL-S-162eP ENO1 HEL-S-87p PMC4143117__F7 Dynamics of BMP Signaling in Limb Bud Mesenchyme and Polydactyly SOX9 COL9A1 COL2A1 PMC3578363__F4 Targeting ubiquitin-dependent degradation of CDK inhibitors CDK2 SKP1 SKP2 PMC3578363__F1 G1 cell cycle control by the pRB pathway CDK6 CDK2 CDK4 PMC2396785__F2 Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle CDC42 RHO SRC PMC5171903__F9 GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment FGFR1 SOX4 FGF2 PMC6964670__F2 Analysing IDO1 inhibitors clinical trial results IFNG TDO2 COX2 IDO1 KYNU AHR IDO2 PMC5834400__F1 Apoptotic signaling through the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) pathway BAX BCL2 DIABLO FADD PMC5832419__F5 Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors HEL107 GCLM PC GPX3 GPX1 PMC3844062__F2 Proposed pathway for NLRP3 inflammasome activation during viral respiratory tract infection NLRP3 IL1B PMC6240570__F1 Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches SUFU APC SMO CTNNB1 PMC7503838__F11 Therapeutic targets for brain injury for nanoparticle mediated drug delivery NPS EPO BDNF PMC8787930__F1 Exosome-liposome hybrid nanoparticle codelivery of TP and miR497 conspicuously overcomes chemoresistant ovarian cancer PC CD47 PMC2810509__F3 BIOLOGY OF VASCULAR MALFORMATIONS OF THE BRAIN SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC7693462__F5 NAA and citrate pathways to acetyl-CoA ACLY ACSS2 NAT8L ASPA PMC3338129__F2 Crosstalk Between Reverse Cholesterol Transport and Innate Immunity STAT3 TLR9 IRF3 TNF ABCA1 MYD88 ABCG1 TLR1 ADAM17 TLR3 TLR4 TLR8 TLR7 PMC7693462__F6 NAA as a selective, alternative cytoplasmic and nuclear acetyl-CoA source ACLY ACSS2 CIC NAT8L ASPA PMC11557815__F3 Impact of P IL13 CXCL16 MYOCD IL6 CCL5 RUNX2 PECAM1 PMC7876332__F7 Scheme about the central role of erianin in ferroptosis induction and migration inhibition BAX CDK2 MTOR CDK4 PMC8112288__F1 Insights on the mechanisms of action of ozone in the medical therapy against COVID-19 KEAP1 MAF PMC9220264__F3 Focus on the Contribution of Oxidative Stress in Skin Aging NQO1 GPX1 PMC3675894__F2 Summary of association of genetic alterations of the HH pathway and cancer type SUFU SHH SMO PMC2496917__F1 Interfering the PI3K/mTOR/p70S6K signaling pathway PI3 PTEN MTOR PMC2871738__F2 Molecular determinants of mitochondrial quality-control networks NBR1 GABARAP FIS1 OPA1 MEN1 MFN2 AUP1 PMC2871738__F3 Role of the major PD-associated genes in mitochondrial dysfunction BAX PINK1 PARL PMC6710038__F7 Schematic model of the mechanism that MIR210HG promotes tumorigenesis and metastasis through a ceRNA pattern in IBC patients SMAD2 PMC6377292__F1 Transcriptional and epigenetic regulation of microglia in health and disease SALL1 AXL CTSH APOE MAFB IRF7 IRF8 BHLHB2 MEF2C TREM2 MIA RUNX1 TMEPAI CX3CR1 MX1 CSF1R PMC10542901__F1 Endothelium as initiator and target of type I IFN responses TBK1 STAT1 CGAS STAT2 IRF9 IRF1 IRF3 CXCL10 TNF PMC9315706__F1 Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target ATG101 ATG3 ATG12 ULK1 UVRAG AMBRA1 BNIP3 BCL2 PMC6359907__F4 Selective autophagy as a potential therapeutic target for neurodegenerative disorders RARA PHLPP1 ATG12 TFEB PMC9315706__F5 Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target ATG101 ULK1 AMBRA1 ULK2 PMC3675657__F7 Mechanisms for iron-dependent and iron-independent IRP2 regulation CDC2 FBXL5 RBX1 SKP1 PMC5402004__F10 Schematic signal transduction network representing the observed changes in protein and lipid metabolism in eWAT during sepsis-recovery RHEB TSC2 TSC1 NLRP3 ATG12 ULK1 UCP1 ATF4 EIF2A ATG5 EIF4E PMC6770250__F1 Basics of transforming growth factor B (TGFB) signaling SMAD2 SMAD4 SKI PMC6770250__F2 TGFB signaling in cholangiocarcinoma (CCA) progression SMAD2 AK4 PMC2810509__F2 BIOLOGY OF VASCULAR MALFORMATIONS OF THE BRAIN ITGB1 RHO PMC6401655__F1 Subcellular localization and function of the eukaryotic LSM complexes LSM1 LSM3 LSM8 LSM5 LSM7 LSM6 LSM4 LSM2 PMC9643504__F3 Hippo signalling pathway and its implications in human health and diseases SIAH2 AMOT BMP2 KIRREL1 SCRIB NF2 NLK PMC9643504__F2 Hippo signalling pathway and its implications in human health and diseases LATS1 LATS2 WWC3 TEAD2 TEAD3 WWC1 WWC2 TEAD4 PMC8065698__F2 UPR drives pro-inflammatory responses to ER stress RIPK2 TLR4 NOD2 NOD1 EIF2A TNF XBP1 TRAF2 MYD88 PMC9059347__F1 Constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection ACAT1 LDLR PMC5389695__F3 SUMO as a regulator of PCNA ubiquitylation and repair pathway choice RAD18 PCNA PMC6042961__F10 FRMD8 stabilises the iRhom2/ADAM17 sheddase complex at the cell surface ADAM17 EGFR PMC3024260__F1 Computational and Experimental Study of the Regulatory Mechanisms of the Complement System CRP HEL-S-62p C2 PC C4A C4B_2 PMC8510680__F6 SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF-1A LATS1 SOX9 HEL-S-133P HEL-S-68p SETD7 PMC8486678__F1 Clinical drug therapies and biologicals currently used or in clinical trial to treat COVID-19 TMPRSS2 CTSL ACE2 PMC8073279__F1 Periconceptional Multivitamin Supplementation on Folate and Homocysteine Levels Depending on Genetic Variants of Methyltetrahydrofolate Reductase in Infertile Japanese Women DHFR PMC3656432__F4 Myostatin (Mstn) pathway GDF8 SMAD4 PMC4928187__F2 Map of lipid metabolic pathways in C LPA PGP MTAP PSD SCD HEL-S-5 PC HEL-S-44 PMC9406587__F3 Proteostasis Deregulation in Neurodegeneration and Its Link with Stress Granules: Focus on the Scaffold and Ribosomal Protein RACK1 ELF2 ATF4 MTOR XBP1 PMC7677084__F9 Network diagram of two pivotal pathways for muscle development in KEGG enrichment analysis MYLK2 MMP7 RGS2 DVL1 WNT16 NFATC1 PPP3CA WNT10A MEF2C BAMBI MYLK RBX1 ADRA1B PRKCE CCND2 PLCB1 ATP1B4 NFATC3 NLK LEF1 PMC11496173__F4 Molecular mechanisms of Keap1-dependent and Keap1-independent modulation of Nrf2 KEAP1 MAF DLD PMC11496173__F5 Probable mechanism of action of ISL on the Nrf2 pathway CSA2 NLRP3 KEAP1 NQO1 SIRT1 PMC5727596__F2 Influence of chosen compounds/proteins on the Wnt signaling pathway which are under consideration as either potential therapeutic targets (continuous line) or potential therapeutic/adjuvant agents (dotted line) PAK1 DKK1 BMP4 PMC3983869__F1 Beta-Catenin is a multifunctional protein that localizes at cell-cell contacts, the nucleus, cytosol and centrosomes APC GSK3B CTNNB1 PMC10310354__F2 Function of Akkermansia muciniphila in type 2 diabetes and related diseases FGF8A APOE UCP1 ADFP PMC10389837__F3 Research Progress on the Etiology and Pathogenesis of Alzheimer's Disease from the Perspective of Chronic Stress CDK5 CRH BACE1 GSK3B PMC4026077__F1 Inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells HHIP KCTD11 PTCH1 SMO MYC GLI3 PMC9603545__F1 Wnt Signaling and Aging of the Gastrointestinal Tract APC LRP5 LRP6 CTNNB1 PMC3960487__F2 Signaling pathways involved in YPP regulation RHEB TSC2 RICTOR TSC1 PTEN PMC2714639__F6 MT1-MMP expression in first trimester trophoblasts is stimulated by insulin, IGF1 and IGF2 by different signalling pathways IGF1 IGF1R IGF2 PMC7693462__F4 Hypothesized role of NAA in cancer cells as an alternative source of acetyl-CoA for specific transcription factor acetylation in place of citrate ACLY ACSS2 EPO CS NAT8L SIRT1 ASPA PMC8166058__F5 Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer SPRED1 SOS1 NF1 PMC9273332__F1 Single-cell deletion analyses show control of pro-T cell developmental speed and pathway by Tcf7, Spi1, Gata3, Bcl11a, Erg, and Bcl11b CD44 CAP2 HOXA9 MEIS1 KIT BBS1 ERG BCL11A CAP1 SPI1 ATL1 GATA3 PMC3328302__F7 Schematic diagram illustrating the proposed interaction between CDH17 and Wnt/Beta-catenin pathway during HCC progression PCNA COX2 APC CCND1 CTNNB1 PMC5768892__F6 Gcn5−/− EBs becomes evident early during EB differentiation GLDC MTHFD2 STAT3 GRB10 INSR SPRY4 RPS6KA2 SRM NMNAT2 BCAT1 MYC PMC8946903__F12 Spermatozoal Mitochondrial Dynamics Markers and Other Functionality-Related Signaling Molecules Exert Circadian-like Response to Repeated Stress of Whole Organism MAPK11 PINK1 UCP3 MAPK13 UCP1 PARK2 NR1C2 MAPK9 MAPK8 MAPK6 MAPK3 UCP2 MAPK14 ADCY8 MFN2 PPARGC1A MAPK12 PRKAR1A NRF1 MAPK1 FIS1 OPA1 TFAM PPARGC1B NR1C1 MAPK7 TFEB PMC2705999__F3 Castration-Adapted Prostate Cancer: Targeting Androgen Metabolic Pathways in Recurrent Disease UGT2B15 CYP17A1 CYP11A1 AKR1C1 CYP7B1 UGT2B17 STS PMC209413__F1 The TGF-&bgr;/Smad pathway and its interrelationship with mediators of inflammatory signals STAT1 SMAD2 NOD2 SMAD4 JAK1 PMC8824786__F1 Functional TGFB1 polymorphism in the donor associates with long-term graft survival after kidney transplantation TGFBR2 SMAD2 SMAD4 TGFBR1 PMC9066914__F6 EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes EGF EGFR APC OLIG2 SOX10 PMC5851616__F9 Tilianin improved myocardial apoptosis HTRA2 BAX PMC6714585__F1 Hedgehog signaling pathway SUFU PTCH1 SHH SMO MYC GLI3 PMC11585128__F7 Secondary BAs regulate liver TH17/Treg cell differentiation to maintain NASH tolerance JUN FOSB CYP8B1 FABP1 CD69 TRAF6 UGT8 CD44 HMGCR BAAT GCA SULT1C2 FOXP3 S100A9 ABCC2 IL23R CD3E PMC4231374__F1 Hypothetical representation of PI3K/AKT/PTEN signaling in pancreatic Beta-cells is shown, which modulate NOXs-derived reactive oxygen species (ROS) generation TSC2 TSC1 GSK3B PTEN HIF1A MTOR CTNNB1 PMC8598044__F1 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion MAVS IRF3 TRAF6 PMC7474398__F6 Distribution of target proteins of the QX1 formula on the integrated “cardiac disease-related pathway.” The cardiac disease-related pathway contained calcium, MAPK, PI3K/AKT, and Toll-like receptor signaling pathways PLN EGF BAD TIRAP EGFR ELL PTEN MYC TRAF6 MYD88 GNAS TLR4 CHUK MDM2 IL1B NOS2 JUN CD14 IL6 TNF MAP3K7IP1 GNE CHRM2 RXRA BCL2 GRB2 LBP TRAF2 PMC8189631__F6 NRF2 induction via FAM129B in mutant BRAF cells RAD51 MAFG KEAP1 GCLM NQO1 GCLC POMP PMC8598044__F2 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion TBK1 STAT1 MAVS STAT2 TLR9 IRF3 PTEN PMC8598044__F3 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion TBK1 MAVS IRF3 LRPPRC PMC8598044__F4 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion STAT2 IRF9 JAK1 TYK2 PMC7471444__F5 Comparative pharmacogenomic analysis of three classic TCM prescriptions for coronary heart disease based on molecular network modeling LPL UBC AQP7 UCP1 HEL-S-28 PLTP PMC8469349__F7 Wharton’s Jelly-Derived Mesenchymal Stem Cells Reduce Fibrosis in a Mouse Model of Duchenne Muscular Dystrophy by Upregulating microRNA 499 SMAD2 SMAD4 DMD PMC545911__F1 Phosphoinositide kinase specific genetic interactions ARF1 VPS41 SYS1 VPS51 ARL1 PMC8818945__F10 Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells BAX NQO1 BCL2 PMC1698524__F5 Model linking HSP70 induction to p33ING1b-induced apoptosis BAX RAN TRADD FADD PMC8629365__F2 Schematic presentation of local translation regulation in dendritic spines of glutamatergic synapses of hippocampal pyramidal cells in response to synapse stimulation RHEB HRAS TSC2 TSC1 RAF1 EIF4E PMC5882662__F6 Metabolic pathways related to the differential metabolites identified in the BDE-3 groups HEL-S-5 GIP CPT2 PMC4399989__F8 Programming of Obesity and Comorbidities in the Progeny: Lessons from a Model of Diet-Induced Obese Parents TG FAS NR1C1 PMC9536090__F5 Differential modulation of cancer‐related genes by mitochondrial DNA haplogroups and the STING DNA sensing system ALK BRCA1 EGFR PMC11079208__F5 Mapping the function of MicroRNAs as a critical regulator of tumor-immune cell communication in breast cancer and potential treatment strategies STAT3 TPM1 BMP6 TIMP3 RECK PTEN IL6 FAP PMC11079208__F3 HER-2/EGFR signaling pathway in breast cancer EGFR SMAD2 SMAD4 PMC6449624__F2 BTLA-associated signaling pathways (stimulatory/inhibitory) regulate the outcomes of HBV-ACLF, liver graft tolerance/rejection, liver cirrhosis and hepatocellular carcinoma CD160 BTLA GRB2 PMC3413220__F1 LCAT functions potentially affecting the pathogenesis of cardiovascular disease ABCG1 APOB ABCA1 PMC7230342__F4 2-step DSB repair pathway choice model [,,] RAD51 BRCA2 ATM PMC12213698__F1 Basics of the canonical Wnt signaling pathway IFNG APC LRP5 IL4 LRP6 IL1B CTNNB1 PMC12213698__F2 Basics of the noncanonical Wnt signaling pathway APC LRP5 LRP6 CTNNB1 PMC2788255__F6 Wnt signalling pathway downregulated in osteosarcoma DVL1 JUN FZD2 APC FZD7 PRKCZ MYC CTNNB1 FRAT1 PRKCI FZD4 FBXW2 FZD3 CTBP1 DVL3 FZD1 NLK LEF1 PMC6580171__F4 Human intermuscular adipose tissue (IMAT) revealed a downregulation of key pathways associated with insulin resistance SOCS1 COX7B NDUFB2 EGF NDUFA12 RAF1 COX1 SOS1 MCL1 PIK3CD NDUFV2 JAK3 CYC1 MTOR NDUFA13 MYC NDUFAB1 COX17 NDUFA10 STAT1 BCL2L1 CCND2 ND6 NDUFB1 ND3 FHL1 ND2 ND1 AOX1 CSF2 PIM1 IRF9 ND4 PTPN11 HRAS SDHA CNTFR CNTF MIA CYB GFAP CREBBP ZNF183 BCL2 GRB2 CISH NDUFS1 SDHC PMC4167640__F2 Two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment LATS1 MOB1A MOBKL1A WBP2 HIPK2 PATJ AMOT ZYX SCRIB AJUBA RHO NF2 PMC4167640__F1 Two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment LATS1 MOB1A MOBKL1A LATS2 PMC11040299__F1 Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer's disease RIPK3 TRADD MLKL RIPK1 TNF FADD PMC11603026__F4 Drug repurposing discovery in Mpox infection CRK BATF EP300 PMC5552148__F2 Generation of ROS as a result of incident radiation affecting the mitochondrion.Notes: ROS have been shown to form oxidative DNA adducts, such as 8-OHdG, which in turn can lead to base modifications and transversions, such as GC to TA ATR COX2 ATM PMC7188831__F3 Adaptors of Salmonella autophagy TBK1 RNF166 OPTN PMC5925168__F2 Pruritic signaling pathways TRPA1 ITCH TRPV1 PLCB3 MRGPRD PMC4935219__F1 Cellular and molecular targets of MTX, 5FU and irinotecan in the small intestine of the AT CDX2 HGF SI GATA4 PMC11821285__F2 Proposed molecular mechanism of ARI in cancer involving modulation of Hippo signaling and Wnt signaling pathway LATS1 APC CTNNB1 PMC11821285__F3 Proposed pathways and molecular interactions for ARI's anticancer effects HTR2B STAT3 DVL3 MTOR SRC PMC7998946__F2 Metabolism of activated T cell and the effect of cancer-induced tumor microenvironment (TME) acidification on T cell response HEL-S-133P HK2 HEL-S-162eP HEL-S-87p PMC11603026__F5 Mpox’s role in antiviral and proviral cell signaling regulation RP1 TH FAS CGAS FAR1 PMC11603026__F6 Mpox manipulation and activation of proviral signaling via AKT, Wnt, and STAT3 signaling pathways STAT3 BAX TBK1 JUN BAD FAS GSK3B IRF3 IRAK2 SOCS3 HIPK2 COX2 TRAF2 CDK4 PMC2787730__F10 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the focal adhesion pathway CRK VASP FYN HEL-S-28 PTEN ARHA PMC9561344__F1 Treatment of myocardial interstitial fibrosis in pathological myocardial hypertrophy SMAD2 SMAD4 ARHA CCL2 TGFBR1 PMC2787730__F11 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the apoptosis pathway BAX NGF BAD FAS TRADD ATM TRAF2 FADD MYD88 PMC2787730__F12 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the cell-adhesion pathway CD226 CD40 TH CD22 PTPRC CD99 JAM2 CD58 GLG1 CD6 ICAM2 CD2 ESAM ICAM3 ITGA4 SELL ITGB7 SELE APC CTLA4 PECAM1 SPN ICOS ITGAM ITGB1 VCAM1 SELP PMC3969740__F2 A) Pathogen recognition receptors RIG-I and TLR3 detect HCV ds RNA and activate via their adaptor molecules IPS-1 and TRIF TLR3 STAT2 IRF9 IRF3 IRF7 EIF2A PMC4383314__F3 Serum starvation induces changes to cellular metabolism and chromatin remodeling proteins NASP HEL60 CHD8 CBX1 FADS2 CBX8 SLC25A3 NDUFAB1 HSD17B12 HDAC3 KDM4A CTCF NPM1 UQCRH FDPS CENPF GCDH ACOX1 CHAF1B MTA2 RNF2 HMGCS1 HMGA1 MEN1 MVD KDM5C KAT8 DHCR7 FAHD2A HMGB2 ASF1B PMC9500245__F6 Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients FOXP3 PMC10040598__F1 The inflammasome in insulin resistance and type 2 diabetes mellitus GRB2 MTOR IRS1 PMC8630042__F1 RAS/MAPK pathway downstream signaling and therapeutic targets RHEB NF1 RRAS MTOR PMC5365060__F3 Biosynthesis of high-carbon sugar nucleoside antibiotics POLK POLG POLI PMC8286267__F7 HBcrAg species, biogenesis, and application as biomarkers to monitor HBV gene expression and replication during natural resolution SHB LHB PMC7566002__F9 A possible molecular network between RASSF1A, the Hippo pathway effector YAP1, AKT, FOXO3A, FOXM1, and ERA based on the findings in this paper and on the published literature CDC2 FOXM1 CDK6 CDK2 PLK1 YAP1 CDK4 PMC2080907__F8 Myc and Ca2+signaling events downstream of the pre-BCR/BCR BLK TEC SYK BTK FYN BCR PLCG2 LYN MYC BIK PMC9399422__F6 Identifying gene variants underlying the pathogenesis of diabetic retinopathy based on integrated genomic and transcriptomic analysis of clinical extreme phenotypes PLEKHG7 SLC38A11 ARHGAP20 MCAM OTOR POM121 EVC2 CUX2 PAPSS2 ARHGEF17 BMP2 TMEM119 NPHP3 IL1B PMC11002909__F2 Antiviral role of ubiquitination in enterovirus infection TRIM7 TRIM38 MAVS TRIM25 IRF3 TRIM65 TRIM21 PMC9162468__F2 Therapeutic strategies to induce mitophagy USP30 PINK1 ULK1 PMC6463794__F6 Summary of the proposed inhibitory mechanisms exhibited by WG-391D in ovarian cancer CDK6 CDKN2C SP1 E2F4 CDC25B CDK4 TGFBR1 PMC7347881__F7 Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling NEUROG2 RIN1 ASCL1 PDGFRA MYC RBPJ HES5 PMC10382180__F3 Immunity by tryptophan microbial metabolites CYP1A2 AHR AHRR CYP1B1 PMC5751200__F2 The BMP-2 signaling pathway plays an important role in the osteogenic differentiation of adipose-derived stem cells (ASCs) SMAD1 BMP2 SMAD4 RUNX2 PMC3058926__F4 Proof of Concept: A review on how network and systems biology approaches aid in the discovery of potent anticancer drug combinations EGR1 CARF LAT CDKN2AIP RELA RELB CREBBP PMC6433978__F2 Complement activation pathways and examples of complement-targeting therapeutics for IgAN C6 CD59 CFHR4 FH C7 CFHR5 HEL-S-62p CFHR1 C4A CR1 CFHR3 C2 CFHR2 C9 C4B_2 PMC4795442__F1 Pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis HEL-S-62p HLA-DRB4 MPO PMC8941137__F10 Beta-cell fitness comparison in Beta-cell replenishment under stress HIF1A MCM2 PMC7998946__F1 Schematic comparison of metabolic pathways between a nontransformed cell and a cancer cell TRO HEL-S-133P HK2 HEL-S-162eP HEL-S-87p PMC7139113__F1 Network for the genes included in mitochondrial functioning processes ZNF746 KIF1B PARK2 NRF1 PMC5366901__F4 Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients FOXA1 PGR GSK3B PMC3995778__F4 Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies GRM3 GRIN2B GRIA2 SHANK1 SLC9A9 SHANK2 PIAS1 PMC3995778__F5 Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies GLS INA TRPC1 PMC9295998__F1 Multi-scale model construction DDT GPX2 MSH2 DPT GPX3 GPX1 YAP1 HEL-S-44 PMC6562738__F5 RAC1 signaling in tumor cells: RAC1 signaling in tumors cells and the involvement of the RAC1 protein in tumorigenesis and drug-resistance as presented in the review CRK PREX1 TIAM1 PAK1 BCL2 GIP GRB2 MTOR SRC RAC1 PMC5094987__F7 EZH2-mediated repression of GSK-3B and TP53 promotes Wnt/Beta-catenin signaling-dependent cell expansion in cervical carcinoma SUZ12 EED APC GSK3B WNT1 EZH2 CTNNB1 PMC1940051__F2 TGFB signaling pathway HGF SMAD2 SMAD4 TGFBR1 PMC4100138__F2 Autophagic cell death in lung tumor cells ULK1 PTEN MTOR ULK2 PMC4237677__F3 Repeat associated non-ATG (RAN) translation: new starts in microsatellite expansion disorders RAN F2 F3 PMC4632830__F1 Heme biosynthesis pathway (in red) connects with glucose (in green) and glutamine (in blue) metabolic pathways CPOX FECH UROD UROS PMC3634451__F2 FGF signalling cascade in Drosophila melanogaster CDC42 GIP GRB2 PMC7862465__F2 Glycosylation changes in TGFB activation and SMAD-dependent pathway SMAD2 SMAD4 PMC4256494__F3 A, Cellular arginine metabolism and putative role of arginase in the development of renal fibrosis ASL PRODH ARG2 PMC4063399__F2 Resistance to vemurafenib HGF BRAF PMC4611759__F1 Type I IFN gene expression TBK1 TLR3 IRAK1 IRF3 TLR7 IRAK4 MYD88 PMC4611759__F2 Cellular response to IFNs STAT1 ADAR JAK1 TYK2 PMC4349729__F2 Simplified view of insulin/IGF1 signaling IGF1 INSR GRB2 MTOR IGF2 PMC4050971__F3 Ingenuity Pathway Analyses: Pathway analyses were from the commercially available Ingenuity Pathway Analysis software ATF3 SSTR4 NGF ZNF230 RASGRF2 TRPC5 IRF7 CP PMC4084493__F2 Non-homologous end joining: emerging themes and unanswered questions PNKP ATR ATRIP RAD51 DNA2 BRCA2 ATM SSB PMC4050971__F4 Ingenuity Pathway Analyses: Details are as in RPS4X CADM3 CADM4 GPR108 PHF23 FAM219A RHO TMEM98 TNNT1 ZC3H15 PTCH1 DEDD ARRDC3 RTKN CP PMC4720263__F4 Signaling crosstalk between the TGF-Beta-activated Smad pathway and the Wnt- and Notch-activated signaling pathways during EMT SMAD2 GSK3B SMAD4 LEF1 CTNNB1 PMC8030716__F1 Entry of the virus leads to activation of the innate immune system which comprises of macrophages and dendritic cells CD40 CD80 APC PDC TNF MYD88 PMC2721684__F1 Signaling pathways triggered by TLR3, TLR4 and TLR1–TLR2 TBK1 TLR3 TIRAP TLR4 IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC4812151__F2 Signaling pathway and biological function of Rap2B, a Ras family small guanosine 5′-triphosphate-binding protein HEL-S-31 GIP RAP2B TNIK PMC5362762__F5 Exploration of small RNA-seq data for small non-coding RNAs in Human Colorectal Cancer APP PTEN PMC11610194__F7 Regulatory networks of critical pattern pathways ZAP70 SYK PIK3CA TICRR CARD11 FLT3LG PIK3R1 ORC1L CCNA2 SKP2 CXCL8 IL6R ADCY8 CTNND2 BCL2L1 SOST FZD3 DKK1 MARCKSL1 CCR1 CACNA1C NTRK2 PTK2B VEGFA FGF10 IRS1 CLCF1 SCIN GPX2 SFRP4 PRKCQ LAP3 BCL2 TRAF1 BDNF HEL-S-64p HEL-75 CREB3L3 WNT10B TNFAIP3 CHAC1 LAT FZD10 CDC6 AKT3 CALML4 CTNNB1 PLCG1 PRKCE CCR6 RYR1 CCND3 PDGFD AOX1 GNB3 KIT IKBKB PPP2R1B RELA JAK1 LEF1 PMC2693146__F8 Model depicting the dual role of cGKI in BMP signalling pathway cGKI regulates BMP signalling through (light blue) modulation of BMP receptors at the cell surface and enhancement of R-Smad phosphorylation and thus Smad activation BMP2 SMAD4 ID1 PMC8764205__F8 Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts CDC42 TF ROR1 SIN3A ROCK2 ROR2 NFATC1 DVL2 RAC1 CTNNB1 WNT5B CDK5 DVL3 PMC6770048__F1 Proposed biosynthetic pathway leading to multiple terpenoids in I IPP AACS MVK PMC7061741__F4 Schematic diagram shows the proposed mechanism by which the Hippo pathway regulates cervical cancer LATS1 LATS2 TGFA EGFR AREG PMC8533819__F3 Involvement of Kynurenine Pathway in Hepatocellular Carcinoma STAT3 IDO1 AHR FOXP3 IL6R PMC7061741__F5 Schematic diagram showing the proposed mechanism by which the Hippo signaling pathway regulates ovarian cancer LATS1 LPA EGFR AMOT FGFR4 FGFR1 FGFR3 AREG FGFR2 PMC7061741__F6 Schematic diagram showing the proposed mechanism by which the Hippo signaling pathway regulates endometrial cancer LATS1 CDH2 FAT4 LPA USP51 EGF LATS2 IGF1 LSR CCND1 GAB2 PMC2719108__F2 Schematic representation of the renin angiotensin system ATR REN DAP ACE2 PMC7061741__F7 Schematic diagram showing putative targets and small molecules specific to the Hippo pathway LATS1 LATS2 AMOT PMC4086823__F3 Stochasticity of Intranuclear Biochemical Reaction Processes Controls the Final Decision of Cell Fate Associated with DNA Damage BAX CASP9 CASP3 PMC4086823__F1 Stochasticity of Intranuclear Biochemical Reaction Processes Controls the Final Decision of Cell Fate Associated with DNA Damage BAX CASP9 CASP3 ATM MDM2 PMC4715999__F2 Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: implications for disease pathogenesis and treatment TF SYK CD79B CD79A CCL3 CD5 CD22 BLNK CD19 BTK PLCG2 CCL4 LYN PMC7368967__F10 Mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation BMPR2 HDAC1 SMAD1 DKFZp781O1323 ID2 MTOR HDAC2 PMC7061741__F2 Hippo pathway in mammals LATS1 SMAD1 CAD TEAD2 TEAD3 SMAD2 TEAD4 PMC12038455__F1 Implication of miR-21-5p and miR-214-5p in regulation of signal transducer and activator of transcription 3 signaling pathway STAT3 MSC PMC5864227__F1 Mutp53 accumulation in tumours is sustained by mechanical inputs through a mevalonate-RhoA-HDAC axis ARHA MDM2 HDAC6 PMC7508753__F2 Contribution of the embryo, fetus, and trophoblasts to the programming of immune adaptations during pregnancy CXCL12 HLA-E HLA-G CXCL2 CXCL6 CXCL3 PMC12185286__F2 Mechanism of BMSCs transplantation on neural plasticity CNTF NGF GDNF BDNF TNF PMC2785342__F8 A proposed model for HA-CD44-mediated PKCE activation and Nanog signaling in the regulation of miRNA-21 production, oncogenesis, and chemoresistance in breast tumor cells CD44 DROSHA PMC3219211__F1 Small-molecule inhibitors in the ubiquitin–proteasome system (UPS) USP14 DDB1 NAE1 USP9X PMC10784739__F7 TIFA regulating the inflammatory and osteoclast differentiation in the RAW264 NLRP3 NFATC1 MMP9 PMC5671979__F6 miRNA-mRNA network LRP4 MAFG CRTC2 DBT PMAIP1 MINK1 TIAL1 DOCK2 SBDS CAMK2N1 SCHIP1 LEFTY1 PDE1B AK2 VPS37B AAG1 FBN2 TDG SMARCA4 NPAS2 MNT TBX1 FOS KIF26B TSLP MAP3K1 CROT IRF2 ATXN1 ADAM10 TOX ASF1B GNAI3 NRK HEL113 SLAIN2 TRPC7 ULK1 CDC6 ANKRD13C ZFAND3 WDR44 TMEM108 CTCF OLIG3 NUFIP2 CLASP2 LIMCH1 EDC3 UNC45A RC3H2 CLIP4 RELL1 PBX3 DHX15 ZBTB44 POLG IQSEC2 PAN3 PDE3A KCNIP4 OSTM1 CC2D1A PFKM YWHAG P2RX4 PTPRU RAB34 RFX1 TSHZ3 LHX8 ASF1A GOLT1A LAMP2 PAPOLA TIA1 PMC12055541__F4 Inflammatory Mechanisms Following SCI: In the acute injury phase: SCI directly causes vascular damage or severing, increasing the permeability of blood vessels GDNF CXCL2 CXCL10 BDNF CCL2 PMC12055541__F5 Molecular Mechanisms of Hydrogel in Improving the Microenvironment of SCI STAT3 BAX CSA2 NLRP3 IGF1 KEAP1 GPX4 TLR4 NQO1 ARG1 BDNF MYD88 PMC9683337__F2 Receptor activator of nuclear factorKB ligand-mediated osteoclastogenesis signaling pathway and related therapeutic natural compounds HEL-S-8a KEAP1 GCLC CTSK AIP OSCAR NFATC1 TRAF6 PMC4406847__F4 ROS are important contributor to renal injury and inflammation NLRP3 TXNIP IL1B PMC5962651__F2 Schematic presentation of autophagy pathway and core autophagy-related proteins targeted by various miRNAs WIPI2 ULK1 VAMP3 UVRAG ATG14 WIPI1 ATG10 LAMP2 ATG3 ATG12 STX7 AMBRA1 ATG5 ULK2 PMC4309185__F2 Imd pathway in the fruit fly and the TNF pathway in the mouse MAP3K7IP1 TRADD TNF TRAF2 PMC6726749__F10 Based on our findings, there are several crucial paths, including PI3/AKT/mTOR as well as HIF-1A activation (in hypoxia) and inhibition (in normoxia) HIF3A PI3 PTEN TSGA10 MTOR PMC4309185__F3 The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway in the fruit fly and the mouse STAT3 COX2 MCL1 JAK1 PMC5640164__F2 Metabolic regulation of the immune humoral response RHEB CD40 ICOS CD80 BAD BCR GC IL21R CD19 PTEN MDM2 PMC4309185__F1 Toll pathway in the fruit fly and the Toll-like receptor (TLR) 4 pathway in the mouse MAP3K7IP1 TLR4 MAL CD14 IRAK1 TRAF6 IRAK4 MYD88 PMC3913901__F2 cIAP1/2 regulation of TNFAlpha-induced canonical NFKB pathway activation and suppression of default death pathways CAP2 CASP8 TRADD MLKL RELA CAP1 TRAF2 FADD PMC3913901__F3 cIAP1/2 regulation of TWEAK-induced non-canonical NFKB pathway activation RELB TRAF3 TRAF2 PMC11784353__F10 Schematic diagrams illustrate how EIAV negatively regulates RLR pathway activation by degrading MAVS TBK1 SMURF1 MAVS IRF3 PMC9284893__F7 RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial–myometrial interface HEL-S-31 RAF1 CACNG8 PPP5C AKT3 STK4 MAP3K11 PPP3CA MAP4K2 TRAF6 TGFBR1 RPS6KA6 TGFBR2 RASA2 FGF9 FGFR1 NRAS DUSP16 CACNB3 TAOK1 FLNB CRKL DUSP4 CACNG4 FOS FGF2 CRK FGF7 RAPGEF2 MAP3K1 SOS2 IKBKB PDGFRA NLK RPS6KA3 MAP3K5 MAP2K1 MAPK8IP2 PMC9284893__F8 RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial–myometrial interface MAX ECSIT CDC42 EGF JUND FAS RAF1 CD14 TNF TRAF6 FLNA MEF2C MYD88 MAP3K7IP1 NLK GRB2 TRAF2 CDC25B PMC11665378__F5 Schematic view of the relationship between ncRNAs and the LC cell progression, invasion, and migration via the PI3K signaling pathway EGFR NQO1 PTEN PMC11665378__F6 Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications CDH2 XB EGFR PTEN IRS1 PMC5372827__F6 Strategies of enhancement of folate level in plants DHFR GGH FPGS DHPS PMC11665378__F3 This schematic illustrates the downstream pathways influenced by AKT activation RHEB TSC2 BAD GSK3B GIP MDM2 MTOR PMC9382085__F8 Chang qing formula ameliorates colitis-associated colorectal cancer via suppressing IL-17/NFKB/STAT3 pathway in mice as revealed by network pharmacology study STAT3 BAX MMP9 PMC11665378__F4 Schematic view of the relationship between ncRNAs and LC cell proliferation and apoptosis via the PI3K signaling pathway BAX NOVA2 CDK6 CCNE1 PTEN METTL3 NOTCH1 CDK4 PMC8072393__F2 Autophagic Organelles in DNA Damage Response ATG12 UVRAG ATG14 ATF4 EIF2A ATG5 XBP1 PMC11665378__F1 Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications MLST8 RICTOR PIK3CD PTEN MTOR PMC9339672__F1 Macrophage Polarization, Metabolic Reprogramming, and Inflammatory Effects in Ischemic Heart Disease GPR32 GPR18 PMC8035741__F5 Graphical representation of the potential apoptotic pathway induced by the Human-RPSA siRNA in late (DLD-1) stage colorectal cancer cell BAX H2AX BNIP1 ATM POP1 CTNNB1 PMC6421413__F8 Protein associations and potential functions of SHARPIN in human megakaryocytes and platelets CD40 SHARPIN OTULIN RELA CYLD PMC7193283__F5 Mechanism of RES on improving NAFLD STAT3 FAS NR1C1 LOXL2 CD36 IL16 TLR4 PLIN1 CIDEC SIRT1 PMC7193283__F3 Mechanism of TSG on improving NAFLD TG FAS NR1C1 ABCG5 CYP2E1 CYP7A1 PMC8374068__F3 Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan BAX IGF1 MTOR IRS1 PMC7193283__F4 Mechanism of emodin on improving NAFLD TG TLR4 SMAD2 ATF4 MTOR EIF2A PMC9409738__F5 Comprehensive Review on the Anti-Cancer Effects of Oleuropein EGFR FASN TFEB MTOR PMC2928307__F1 Plastids play a central role in the generation of wounding and herbivory induced signals FAS LOX GLA PMC11544107__F5 Aripiprazole-target-disease-pathway network and molecular docking results of aripiprazole with core targets ABCC1 TACR2 AK3 CHRM3 KDM4B IRAK4 ALB HCN4 EGLN1 DRD1 HTR1B ADRA1B FYN DRD2 DRD4 ADRA2B FGFR1 HCN1 CSF1R ABCB1 HTR1D TNF GRM2 CHRM2 OPRD1 ADRB2 ADRB1 RET HTR7 SGPL1 CHRM1 ADRA1A HTR2A DRD3 HTR6 OPRK1 BTK RIPK2 SLC6A3 SSTR2 NR3A2 5HT1A GALR3 ABCG2 HTR1E ACHE HRH1 SLC22A1 OPRM1 NR2F2 DRD5 ADRA2C LYN CYP3A4 HRH2 PMC8985313__F8 Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling STAT3 STAT1 FPR1 ANXA1 FPR2 PMC11544107__F4 Distribution of key targets in the two main pathways PMCH NTS NPS SPR CCK LEP SCTR HEL-S-62p CRH GHRH CYC1 GIP NMU CTSG FSHR LHCGR DAO THRA CORT LPA NPFF APLN POMC NPY SPX PROC KNG1 GHR HCRT OXT MLN ABRA GAL ADM SELE GHB3 CALCR APELA GALR1 BRS3 EDNRA PBR NPB PTH SCT GIPR AVP PMC7328045__F1 Proposed inhibition of SARS-CoV-2 entry/replication by intervention at the NPC1 pathway TMPRSS2 NPC1 ACE2 PMC8841848__F3 Evasion of Host Antiviral Innate Immunity by Paramyxovirus Accessory Proteins STAT1 TRIM25 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC7759481__F1 Induction of IFNs and the antiviral state they exhibit in bat (P TBK1 JUN MAVS STAT2 RNASEL IRF3 IRF7 ATF2 TRAF3 RAC1 MYD88 STAT1 ISG15 JAK1 OAS1 TYK2 PMC2677440__F7 Rhinovirus-Induced Major Airway Mucin Production Involves a Novel TLR3-EGFR–Dependent Pathway MUC5AC TGFA TLR3 EGFR AREG PMC11743330__F2 MiR‐30a‐5p inhibiting the Wnt/B‐catenin signaling pathway APC LRP5 LRP6 PMC4796280__F2 Store-dependent and -independent Ca2+ entry pathways in smooth muscle ORAI3 ORAI1 LTC4S STIM1 MTOR EIF4E PMC6826537__F1 Pathways controlling the epithelial-mesenchymal transition (EMT) program in prostate cancer (PC) CDH2 HES2 SMAD2 GSK3B FAP HES1 CTNNB1 PMC3900298__F5 New immunological approaches in treating and diagnosing CNS diseases TRPV1 SHH GLI3 PMC4747375__F7 Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma EGFR AREG PMC5532623__F2 MET regulated signaling pathways implicated in the hallmarks of cancer STAT3 CRK HGF SRC PMC3647962__F13 TNFA signaling pathways to IKK activation TH TRADD TRAF2 PMC8706409__F10 Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage STAT3 RAF1 IKBKB GATA4 TNF PMC2949127__F3 HMGB1 signaling events mediated by RAGE and TLR2/4 and therapeutic strategies for cerebral ischemia CDC42 HMGB1 TLR4 TRAF6 RAC1 MYD88 PMC9410782__F1 Advances in Research on the Molecular Function and Specific Role of Circular RNA in Cardiovascular Diseases HMOX1 PINK1 QK3 FOXO1 AKT3 LRP6 ARC SIRT1 MYD88 PMC6734673__F2 Epidermal growth factor receptor Pathway and its two pathways: Ras/Raf/Mitogen-activated protein kinases or PI3K/AKT EGFR PTEN GRB2 MTOR PMC5698505__F3 mTOR signaling RHEB TSC2 PTEN HIF1A PMC6559821__F3 Main signaling involved in non-canonical pathways regulating HIF-1/2 RPS6 PTEN MTOR VHL PMC6147171__F3 Mechanisms contributing to the repression of hepatic gluconeogenesis by Wnt signaling activation TCF7L2 CRTC2 PCK1 PMC9359802__F4 Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines MAVS TLR3 RNASEL PMC5628821__F6 Design and validation of a 90K SNP genotyping assay for the water buffalo (Bubalus bubalis) PML SDR39U1 ORMDL2 SLC7A6OS NRXN1 TMEM87B SMIM7 DHX35 TMEM208 ZNF701 SLC26A11 ZNF586 ZNF222 PURG MLIP SYT13 GDAP2 C5orf34 TINAG ME3 RNF44 NR2A1 MRM1 P3H2 LMNA PMC6147171__F1 A) A simplified schematic of the Wnt signaling pathway APC LRP5 LRP6 INS PMC9332329__F2 Interactions between phages and immune system components are varied and complex TH TLR1 TLR3 IL13 F3 TLR9 AIM2 MYD88 PMC6135464__F5 Pathway visualisation TES SI PMC3190874__F2 FcERI signaling pathway is negatively regulated by a number of cell surface and intracellular proteins that act at various points in the FcERI signaling network SYK BTK FYN LAT TLR4 CSK LYN PMC9263675__F4 Update on the pathogenesis of vitiligo CXCL9 IFNG CXCR3 STAT1 JAK3 JAK1 CXCL10 IL15RA PMC3190874__F1 Immunoglobulin E Receptor Signaling and Asthma SYK BTK FYN LAT LYN MTOR PMC4884112__F8 Proposed crosstalk between EGFR signaling pathway and Hippo pathway in the diabetic kidney LATS1 HBEGF EGFR SMAD2 AREG PMC9949365__F1 Orthogonal Functional Genomic and Proteomic Analyses Nominate AKT Activation as an Actionable Consequence of Selinexor Treatment PIK3R5 AKT3 GSK3B PTEN MTOR PLK1 DEPTOR TSC2 RICTOR MAPKAP1 TSC1 KY PDPK1 FADD PMC9015684__F1 Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants EGF EGFR PTEN SRC PMC8458546__F3 Proliferative diabetic retinopathy transcriptomes reveal angiogenesis, anti-angiogenic therapy escape mechanisms, fibrosis and lymphatic involvement CASP8 PROK1 NRP1 MMP9 VEGFA ITGAV PLA2G2A NOSIP RAP2A RALB ANGPT1 ITGA1 NR2F2 LPAR4 GUCY1A2 PLCG2 CASP3 CHRNE ADCY1 NOSTRIN GRB2 RASD2 NOTCH1 PMC9479335__F5 Case report of the sustained and rapid response of bevacizumab in a TP53-positive breast cancer and liver metastatic patient through personalized medicine PTEN MDM2 MTOR PMC7086291__F2 Leukocyte extravasation signaling JAM2 ITGAM ITGB1 ITGB4 MMP9 JAM3 PMC7086291__F3 Tec kinase signaling TEC SRC PMC7086291__F4 Osteoarthritis signaling NOS2 FRZB SMAD1 ADAMTS4 WNT16 TLR4 SP7 IL8RB COL2A1 ELF3 CTNNB1 PMC6618585__F2 Tumorigenic mechanisms of Fusobacterium nucleatum in colorectal cancer TIGIT TLR4 MYD88 BIRC3 PMC7139528__F6 Nervous system interaction effects of the KEGG enrichment pathway terms and putative target proteins identified in A CREB3 HTR4 CHRM1 AKT3 TRPC1 DRD3 MAOA GNAS DRD1 FYN DRD2 5HT1A PTGS1 PRKCA APP ALOX12 MAPK1 ACHE CACNA1C GNB5 CALY CHRNA7 GNAL GRM2 FOS ARAF HRAS CHRM2 DRD5 PLCB1 CASP3 BCL2 MAP2K1 PLA2G4B PMC8226978__F1 Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management STAT3 BAD GC BCL2 PTEN PMC6892284__F1 Number of studies suggest that an increase in microbial BSH activity results in a reduction in stimulation of intestinal FXR FGF8A ABCG8 ABCG5 CYP7A1 PMC9200584__F3 Integrating Network Pharmacology and Experimental Validation to Explore the Key Mechanism of Gubitong Recipe in the Treatment of Osteoarthritis EGF EGFR MCL1 MYC CCL2 COL3A1 CXCL8 MAPK3 MAPK14 HMOX1 IFNG BCL2L1 NLRP3 PRKCA CHUK MMP3 KDR CASP9 NOS2 JUN SELE CXCL2 PTGS2 MMP9 VEGFA TNF CXCL10 FOS SPP1 CXCL11 RELA IKBKB CASP3 NFKBIA BCL2 PMC5394985__F1 Interluekin-17A (IL17A) STAT3 RORC IL16 CXCL1 CCL2 CXCL8 RORA PMC11252768__F8 Working summary of the study HMGCR SUFU SMO PMC6496424__F1 Multiple mechanisms involved in the protective roles of NLRP6 in intestinal epithelial cells IF2B1 NLRP6 CCR5 MUC2 IL18 IL6 CCL5 MYD88 PMC7186417__F5 Pro- and anti-fibrogenic effects of LPS on activated HSCs STAT3 IL10 IF2B1 IL16 TLR4 SMAD4 IL17A PMC4873813__F2 Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism STAT3 INSR CD36 PC SOCS3 IL6 MTOR INS IRS1 PMC8069635__F3 Immune response pathway of SARS-CoV-2 TMPRSS2 ACE2 PMC2099483__F1 Circadian oscillation in leptin signaling pathway in mouse brown fat STAT3 LEP LEPR SOCS3 PMC8342764__F3 Cerebral Autoregulation in Subarachnoid Hemorrhage SPHK1 CFTR TNF PMC9441491__F7 Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis STAT3 HEL-S-133P HK2 FGFR1 HIF1A MTOR IRS1 PMC5821995__F3 Macrophage polarization in type 2 diabetes PKNOX1 CCND2 IL16 ATM CCND1 IL1B CTNNB1 PMC8115150__F8 Schematic model describing the protective effect of Mzb1 in AMI. Injury of cardiomyocytes led to apoptosis and mitochondrial dysfunction, ROS release, and increased inflammation BAX TNF PMC1526596__F1 P38 mitogen-activated protein kinase (MAPK) signaling cascade in T cells ZAP70 GADD45B GADD45A PMC6770807__F6 Proposed action mechanism of 6SL CDK6 PCNA PMC5893867__F1 Fasciola hepatica modulates macrophage activation NLRP3 TLR3 TLR4 PRX CD14 PMC6561619__F10 Model of the molecular mechanisms involved in LRRK2 gene silencing in proliferation, migration, and apoptosis in TC cells BAX LRRK2 CDK4 PMC8863805__F1 An enhanced triple fluorescence flow-cytometry-based assay shows differential activation of the Notch signaling pathway by human papillomavirus E6 proteins MAML1 ADAM10 HES1 PMC3600829__F4 Functional analysis of the gene expression networks, performed using Ingenuity Pathway Analysis (IPA) FLT3 ORM1 TGFBR3 SIGLEC5 CR1 IFNG KCNA3 IL2RB RNF125 GRB10 NEDD4 STAT5B IRAK3 TIFA LCN2 CD163 PMC3350083__F1 Overlap in FcERI, FcGRIII, and FcGRIIB signaling SYK TGFB1 FYN CSK LYN PMC2936296__F2 RIG-I signalling pathway TH MAVS RALA ATG12 MAK RELA MAF PMC7961611__F1 Transsulfuration pathway (TSP) and related pathways HPD HEL-S-182mP HEL-S-61p PMC2652403__F1 Signalling through the phosphatidylinositol 3-kinase (PI3K) affects cell growth, apoptosis and cell cycle regulation RHEB TSC2 BAD TSC1 PTEN MDM2 MTOR CTNNB1 PMC7961611__F2 Hydrogen sulfide production pathways PMC6107379__F1 RAS/mitogen-activated protein kinase (MAPK) signaling pathway and associated developmental syndromes (indicated by dashed lines) CBL SPRED1 SOS1 NF1 SHOC2 BRAF CS GRB2 KRAS PMC4076960__F8 Muscle hypertrophy and atrophy MAPK1 RPTOR ACVR2B MYOD1 GDF8 HGF MYF6 GSK3B MYF5 NFATC1 IGF1R MTOR PPP3CA MAPK8 TRIM63 FBXO32 FGF2 EIF4E MAPK14 MYOG IGF1 CDKN1A FST CALM1 PMC9152764__F1 High Intensity Interval Training: A Potential Method for Treating Sarcopenia RHEB TFAM RPS6 EIF4B EEF2 SIRT1 EIF4E PMC11940482__F5 Calcium signaling pathway with RMPs TRDN PLN CAV3 CAV2 HRC BCR PI3 TFEB MCU HEL-S-11 PMC6050811__F1 The cyclin D1–CDK4/6–RB pathway in breast cancer.The role of the cyclin D1–CDK4/6-RB pathway in breast cancer cells, including cross talk with other oncogenic signaling pathways TSC2 CDK6 EGFR MTOR CCND1 CDK4 PMC7594502__F2 Mitophagy pathways in health and disease PHB2 TBK1 NLRX1 BNIP3 FUNDC1 OPTN PMC6289780__F4 Representative terpenoid biosynthesis pathway with cognate heat maps for transcript levels of genes GGPS1 IDI2 IPP IDI1 PMC9373848__F1 Autophagy in Adrenal Tumors ATG12 AMBRA1 ATG5 EEA1 PMC11814419__F6 Schematic for the mechanism by which PGAM1 functions to promote the malignant phenotypes of BC via the Wnt/Beta-Catenin signaling pathway PGAM1 APC GSK3B CTNNB1 PMC2923738__F4 Human erythrocyte metabolism modeled using detailed enzyme rate equations GRAP HEL-S-162eP KIN PMC9598206__F7 GPX4 Alleviates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting Ferroptosis GPX4 LPCAT3 FACL4 PMC3249418__F3 Migration of marginal zone precursor B cells regulated by type I interferon (IFN) and IL-17 CXCL13 CD69 PDC CXCR5 PMC5054603__F3 Gene expression changes in neurotransmitter signaling pathways GNGT1 GABARAP GPHN GNG5 GSK3B GNG12 PLCL1 MAPK9 ATF2 MAPK8 PPP2R5E MAPK3 GABRG2 CAMK2A FYN DRD4 MAPK1 CACNA1A GNB2 FOS GABRA6 GABRA3 KIF5A GABRA2 GNA11 PLCB2 BCL2 MAPK10 ADCY1 GNG7 GNAI3 GRIA2 GNAO1 PIK3R5 MAPK13 GABRB2 PIK3R3 AKT3 GABBR2 GABRA4 GNGT2 GABRG3 DRD3 GNB1 GABRE CHRNA6 HEL-S-80p ADCY6 GABRQ GABRP GNAI1 GNB3 GNG10 GNG4 GNG13 GNB5 KCNJ6 GABRB3 GNAL PPP2R1A GNG3 GNG8 GNG2 GABRG1 GSK3A HAP1 GNB4 TRAK2 GNG11 PMC5877574__F2 The signaling pathways in response to DNA damage and key effectors that interact with ER signaling CDC2 ATR ATM MDM2 CDK4 PMC6826993__F2 After co-culture between adipocytes and breast cancer (BC) cells, high levels of miR-144 and miR-126 were released by exosomes by BC cells STAT3 LEP SOX9 RETN PLOD2 MTOR SRC TNF IRS1 PMC5054603__F4 Gene expression changes in the elements of postsynaptic signaling cascades GNAI3 GNGT1 GRIA3 NCALD RAF1 GNG5 GNG12 GABBR2 GNGT2 PRKCB PDPK1 CHRNE PRKCA GRIN1 GRIA4 MAPK1 GNAI1 AP2S1 GNG10 GNB2 GABRB3 GNAL GNG8 GNG2 GRIK3 AKAP5 CHRNG PLCB2 PICK1 GNG7 PMC8573439__F1 Mechanisms and pharmacological applications of ferroptosis: a narrative review TF IREB2 SLC3A2 IPP SLC7A1 LOX STEAP3 KEAP1 GPX4 LPCAT3 HEL-S-102 ATG5 PMC11803289__F2 How S1P works S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 PMC7073561__F1 Lipid biosynthesis UGCG SMS FASN PMC3075710__F3 Regulated fatty acid synthesis and metabolism during cell differentiation C6 TG ACSL5 FABP5 PCNA C2 CERS2 FACL4 FABP4 PMC6495170__F2 Ceramide metabolism CERS3 CERS5 SMS tmp_locus_29 CERS1 CERS2 CERS6 PMC9334647__F2 Caveolin-1 in Sepsis – A Mini-Review VEGFA RAC1 PMC2670612__F2 Tumor resistance to EGFR-targeted therapies EGFR PTEN GRB2 RALBP1 PMC5259950__F6 Canonical Rho signaling pathways were identified in a phosphoproteomics screen of HIV-1 signaling via CD4 and CCR5 CDC42 EGF TRIO FGD1 PXN APC GNG12 CD14 ARHA FLNA DOCK1 HEL114 CRK F2R GRB2 BAIAP2 LBP PMC3199279__F2 Metabolic interactions between folates and vitamins B12, B6, and B2 DHFR HEL-S-61p PMC7773902__F2 Summary of the different therapeutics applied in aGVHD treatment APC HEL-S-171mP MSC CTLA4 PMC5841936__F2 Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling FYN C2 CSK LCK CD1D PMC5215107__F3 Genetic and Developmental Basis of Cardiovascular Malformations TBR1 SMAD1 TGFB1 DKFZp781O1323 SMAD2 BMP4 BMP2 SMAD4 PMC5841936__F3 Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling IFNG C2 ELL CSK IL2 PMC6697739__F6 An illustration of the bidirectional interaction between Th17 and BEC IFNG STAT3 CCR6 AHR TNF CCL20 PMC7523953__F4 Comparative transcriptome analysis reveals candidate genes related to cadmium accumulation and tolerance in two almond mushroom (Agaricus brasiliensis) strains with contrasting cadmium tolerance ACLY UGDH RER1 HEL-S-32 HP PMC3900785__F1 The metabolic pathway of homocysteine PMC5578024__F8 Differentially expressed genes associated with the cell cycle were annotated by KEGG DBF4 CDK7 PCNA E2F4 SMC3 SMAD4 CDK2 MDM2 MYT1 SKP2 ORC2 PMC10754983__F7 Current insight on the mechanisms of programmed cell death in sepsis-induced myocardial dysfunction ULK1 PTEN MTOR PMC3868899__F8 Nicotine’s effect on immunity via the A4 nAChR signaling pathway in T cells CDC42 GPRIN1 PMC4197746__F2 mTOR controls metabolism MLST8 CAD ULK1 ATG14 IGF2 PMC5503208__F2 Molecular mechanisms of dietary fat absorption within enterocytes CIDEB FAS ACSL5 ACSL3 LPCAT2 ADFP PMC4197746__F1 Upstream of mTOR: classical and non-classical inputs ULK1 APC GSK3B LRP5 LRP6 PTEN MTOR RAC1 IRS1 RHEB MLST8 TSC2 RICTOR TSC1 GRB10 TBC1D7 PMC11251740__F1 Clinically relevant dysregulated pathways in GBM CDKN2A CDK6 NF1 EGFR PDGFRA PTEN MDM2 MTOR CDK4 PMC7295046__F9 Schematic illustration showing the proposed mechanism by which FABP5 promotes LNM of CCa by regulating FA metabolism VEGFC FABP5 FASN MMP9 TWIST1 PMC4340667__F4 Targeting mitochondria metabolism for cancer therapy MTHFD2 MTHFD1 HEL-S-44 PMC5362638__F2 MyomiR interaction with Akt-mTORC1 signaling pathway RPS6 IRS1 EIF4E PMC3414811__F2 Two branches of the unfolded protein response BCL2 ATF4 EIF2A XBP1 TRAF2 PMC3414811__F3 The mechanism of SLS SEC63 EIF2A TBP PMC8124393__F2 Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises GSK3B LRP5 LRP6 PTEN MTOR CTNNB1 PMC7081367__F3 Disorders Caused by Genetic Mosaicism NF1 PTEN MTOR PMC9407616__F9 Transcriptome Analysis Identifies Key Metabolic Changes in the Brain of Takifugu rubripes in Response to Chronic Hypoxia AMPH HMGB1 CD59 PFKFB4 ABLIM3 ENO2 HEL-S-30 PRXL2B HADHB PDE1A PLPP2 PLCB1 NPY HEL-S-61p HEL-S-87p PMC8946740__F10 Proposed model of ARF-IFNB pathway STAT1 GDF8 STAT2 IFNAR2 IRF9 IFNAR1 BCL6 PMC3478592__F1 Model depicts the development of conventional vs ITK IRF4 PMC4715152__F1 TRAF2 signal pathway networks CD40 LTBR TRADD TRAF3 TNF TRAF2 PMC4715152__F3 WWOX/WOX1 and signaling networks HGF ERBB4 WWOX HYAL2 RUNX2 PMC7718394__F5 Simplified diagram illustrating altered innate signaling following BCG treatment of HU and HEU monocytes TNFAIP6 IL19 CSF2 TNLG1B CCL3 CXCL1 CCL7 CXCL2 PTGS2 IL23A MYD88 PMC4695002__F6 STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation SMARCC1 STAT3 EGR1 MSH2 SP1 ECT2 VMP1 TFAP2A MYC FBXL7 EGR4 RAD54B RBMS3 NCOR1 NFIB CREB1 PMC4736761__F4 Changes in genes associated with epithelial-to-mesenchymal transition after radiation TRIR TGFA HEL-S-62p MTSS1 TRAF6 BMI1 EPCAM MME ZBTB7A GDF15 NRAS JAG2 MMP3 ZFPM1 TRIB3 CDH2 TIMP3 CSF2 KLF6 LIF PLAUR FASN TNS4 STC2 MMP9 IL6 FAP SET VCAN ID3 HRAS BMP6 RICTOR ADRB2 HAS2 XDH PTGES LCN2 CSPG4 PMC5426651__F13 Mechanism of GnRH-(1–5) action in Ishikawa cells EGF GPR101 EGFR PMC4736761__F3 Cellular processes common to all nine cancer stem cell- (CSC-) associated genes BMI1 CD44 EGFR SOX2 CD133 NOTCH1 PMC7226484__F2 L-cysteine metabolism CTH SUOX PMC4695002__F2 STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation RPTOR STAT3 IRF6 NOC4L SYNC LAMC2 DSG2 CD133 MCRS1 MTOR BAG6 SRC PMC1195384__F2 Folate pathway in Plasmodium falciparum and the proposed mode of action of the diaminopteridines, analogs of folate precursors DHFR DAP FPGS DHPS PMC3943663__F1 Dendritic cells in progression and pathology of HIV infection TRIM5 CCR5 CXCR4 PMC89003__F2 IFN signaling by the Jak-Stat pathway STAT1 IFNGR1 IFNAR2 JAK1 TYK2 PMC8616143__F1 Unfolded Protein Response as a Guardian of the Secretory Pathway ATF4 EIF2A XBP1 PMC11311379__F9 Regulatory effects of novel-m0230-3p on cell TJs and adhesion via CSF1/CSF1R/Ras signaling pathway in yak SCs CSF1 CSF1R PMC5119498__F1 Factors Implicated in Insulin/Growth Factor-Induced Regulation of Mammalian or Mechanistic Target of Rapamycin (mTOR) Complex-1 (mTORC1) RHEB MLST8 TSC2 TSC1 ULK1 TFEB MTOR PMC5228376__F3 Cytokine-cytokine receptor interaction of secreted cytokines FLT3 EGF CSF1 HGF CCL3 EGFR CCL15 CCL26 FLT3LG CCR3 CCL23 VEGFB FLT4 CCL7 FLT1 KDR CSF1R CCR1 CCL16 CCL11 KIT VEGFA KITLG CCL14 CCL13 CCL24 CCL4 CCL8 PMC6083487__F4 Cyclins and cell cycle regulation is the top pathway downregulated by citalopram treatment ATR PTS MYT1 PMC6463920__F6 Microgravity regulates cell proliferation and cell cycle via the CD117-Ras/cAMP-CREB pathway CDC2 CCND3 CCND2 E2F2 ATF4 MAP2K1 DUSP2 CCND1 PMC5866782__F2 Free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines CDH2 PMC3389589__F1 Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target RHEB TSC2 PTEN MTOR EIF4E PMC3580761__F2 Regulation network of CYP3A4 phenotype expression adapted from Klein et al NR1i1 EBP USF1 ALAS1 SLCO1B1 FOXA3 IL6 IL6R POR RARA NR1C1 SLCO2B1 IL1RN PGRMC2 RXRA IL6ST PGRMC1 PMC1857250__F2 Tregs and rethinking cancer immunotherapy CTLA4 FOXP3 PMC5064863__F5 Endocrine related Hippo Signaling Pathway NKD1 RASSF6 ID2 PATJ APC SOX2 PALS1 AREG MYC AXIN2 ID1 CTNNB1 LATS1 BIRC5 LATS2 AFP AMOT SCRIB AMH BIRC2 PMC4855716__F6 miRNA-gene network in the steroid hormone biosynthesis pathway and regulatory network in early sex differentiation of Nile tilapia DMRT1 CYP11B2 AMH PMC9443660__F5A Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis ADAR COMP tal-1 C2 MAK GLA ACE2 PMC4000931__F3 Summary of the miRNAs and the VEGF pathway involved in HSCs CASP9 SPRED1 CCND1 PMC12084487__F2 Specific signaling pathways mediated programmed cell death in tumor microenvironment and target therapies RIPK3 ZBP1 MLKL RIPK1 FADD PMC12084487__F3 In the mTOR signaling pathway, PI3 K/AKT/mTOR axis can induce the occurrence of apoptosis MLST8 BAX BAD RIPK2 GPX4 ULK1 TTI1 RIPK1 SLC7A11 DEPTOR PMC7383642__F1 Reported coagulation pathway variations in African Americans VWF PLG FDPS PMC6100747__F3 Notch signaling pathway EGF DLL4 JAG2 ADAM10 HIF1A MYC PIN1 DLL3 AEN PMC6100747__F1 Ischemic stroke initiates cell death mechanisms in brain cells following an acute depletion of blood flow, resulting in the formation of an infarct core IL1B PMC7230881__F7 Summary of the cellular response to oxidative stress in CC4348 (A) and the gpx5 mutant (B) HEL-S-75p GPX1 HEL-75 PMC10758606__F1 NFKB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells CD40 RELA RELB PMC12056177__F7 Schematic description of kinase signaling pathways in Alzheimer’s disease STAT3 BAX TTBK1 GSK3B BACE1 MTOR ERBB3 HDAC1 CDK5 FYN EEF2 ATM APP ADAM10 BDNF SIRT1 CDC25B PMC12056177__F8 Schematic description of kinase signaling pathways in Parkinson’s disease FKBP5 PINK1 LRRK2 AIMP2 PARP1 PMC6040236__F7 Schematic for alternative complement pathway activity in fHm/m/fP−/− mice RPE FH HEL-S-62p PRL PMC12056177__F9 Schematic description of kinase signaling pathways in Huntington’s disease CDK5 IGF1 MTOR BDNF HTT PMC12056177__F6 MAP3K-MAP2K-MAPK signaling pathway MAP3K11 GRB2 PMC7037688__F2 NF-E2 p45-related factor 2 (NRF2) transcription pathway and evaluation of potential biomarkers in Friedreich’s ataxia FXN HEL-S-112 GPX4 NCF2 PMC6100747__F5 Following stroke, the stability of NICD is increased by its interaction with Pin1, and the NICD-Pin1 complex then translocates to the nucleus HIF1A PIN1 AEN VHL PMC4995965__F4 DVL phosphorylation by NEK2 affects Wnt signaling NEK2 INS PMC10380727__F2 Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect C6 SMAD2 TRPC6 CTNNB1 PMC6810715__F2 Clinical and Molecular Phenotyping in Scleromyxedema Pre- and Post-Treatment with Intravenous Immunoglobulin CDC42 SMAD1 DKFZp781O1323 TGFB1 RAF1 SMAD2 SMAD4 NODAL MAP2 TGIF1 RUNX2 TRAF6 FOXH1 MAP2K4 TMEPAI HOXC9 TLX2 NKX2-5 AMH NR1i1 JUN MAP4K1 SMAD6 BMP7 IRF7 PITX2 FOS SKI HDAC1 NR2A1 SMURF1 MAP3K7IP1 ZNF423 MAP3K7 BCL2 GSC MAP2K1 GRB2 SMURF2 RNF111 PMC7991106__F1 Process of glycometabolism in ECs FOXO1 F2 HK2 HEL-S-30 PMC2897145__F7 Molecularly and temporally separable lineages comprise the hindbrain roof plate and contribute differentially to the choroid plexus gdf7 LAT CP PMC7248369__F7 Integration of transcriptomic and metabolomic data GAA HEL-S-2 CGN NEIL2 RRM2 FASN SLC6A19 GPX3 TYMS MYC RB1 PAICS HPGD LAP3 CNR2 SLC16A2 HAAO BCAT1 ADCY1 PMC7867633__F4 Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes PRLR POLL IGF1 ULK1 PRL POLI SMN1 PTEN EIF4E PMC4301186__F1 Interplay between lifespan regulation and brain function MTOR FOXO6 SIRT1 PMC3010981__F1 Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells MUC5AC MUC5B PMC7867633__F1 Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes TFAM POLL POLI NRF1 POLRMT PMC6768965__F1 Manipulation of the interferon signaling pathway in myeloid cells TBK1 CGAS MAVS DDX41 IRF1 IRF3 TRAF3 CPSF6 TREX1 PMC7867633__F3 Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes POLL SP1 SOS1 EGFR POLI GRB2 PMC7246472__F2 Activators and inhibitors of Wnt/Beta-catenin signaling pathway SFRP5 HMGB1 BMP2 PTH1R RUNX2 SIRT1 MSX2 CTNNB1 PMC6959606__F4 Gene expression profiling of Trypanosoma cruzi in the presence of heme points to glycosomal metabolic adaptation of epimastigotes inside the vector HEL-S-1a PMC12240186__F1 Mechanistic basis of XPO1 dependency RB1 SOX2 HDAC7 MYC CTNNB1 PMC3554769__F1 Mathematical Model for MicroRNA in Lung Cancer HMGA2 MYC PMC8531217__F6 Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development CYP51A1 EBP SQLE SC5D DHCR24 DHCR7 CYP46A1 HSD17B7 TM7SF2 PMC3958036__F9 Schematic model of how SH2B1B enhances gene expression and neuronal differentiation through STAT3 (step 1) CDH2 STAT3 EGR1 FGFR1 SH2B1 PMC8000236__F6 Top predictive features for not mutated IGHV CLL patients CDC42 NR1C1 CXCR1 IGF1 TP63 PMC8531217__F1 Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development HMGCR SQLE PMC7348140__F6 LncRNA NR2F1‐AS1 promoting breast cancer angiogenesis through IGF‐1/IGF‐1R/ERK pathway via sponging miRNA‐338‐3p IGF1 IGF1R PMC4439933__F4 Detailed self-regulation scheme of cancer development in ERG+ well differentiated tumor samples HRAS BMP4 GRIP1 RAP1A NRAS BMP7 HIF1A GRB2 ERG CTNNB1 FGF2 PMC8000236__F7 Top predictive features for IGHV-mutated CLL patients CDC42 NR1C1 CXCR1 MTOR PMC11936945__F1 TRAIL-DR5 related cell death regulation signaling pathway (Das et al STAT3 BAX CASP9 TRPM7 ATR CASP8 MLKL GSDMC AIP TNF RIPK3 GSDMD NLRP3 CASP3 BCL2 ATM APAF1 TRAF2 PMC4220672__F1 Novel strategy for the use of leptin for obesity therapy STAT3 LEPR PMC8062588__F2 Cancer stem cells and strategies for targeted drug delivery BAX BAD RAD50 RAD51 MCL1 SOX2 EZH2 TSG101 MYC KRAS XBP1 BMI1 EPCAM BRCA1 CD9 ATM ATF4 ABCG2 NRF1 CD63 IL1B PMC8997719__F6 Total and Mitochondrial Transcriptomic and Proteomic Insights into Regulation of Bioenergetic Processes for Shoot Fast-Growth Initiation in Moso Bamboo DLAT OGDH HEL-S-162eP MAL PDC CS PMC6335102__F10 Renal ion regulation in response to ANG II NHERF1 WNK4 DCT PMC5904535__F12 NF-Kb signaling pathway regulates cellular inflammatory, oxidative and apoptosis FAS MPO PMC11360101__F13 Actin Dysregulation Mediates Nephrotoxicity of Cassiae Semen Aqueous Extracts CDC42 ARHA RAC1 PMC6335102__F13 ANG II signaling in aging TSC1 MTOR PMC8283198__F2 Role of Protein Kinase C in the Pathophysiology of Diabetes-Associated Atherosclerosis PCSK9 LDLR VCAM1 PMC8265274__F3 F-Actin Dynamics in the Regulation of Endosomal Recycling and Immune Synapse Assembly CDC42 CD80 VAMP3 APC MAL ARL13B RAB7L1 RAC1 VAMP7 STX16 INF2 CCDC28B SNX4 IFT20 RAB35 ARL3 UNC119 PMC3334963__F7 Transcriptomics of In Vitro Immune-Stimulated Hemocytes from the Manila Clam Ruditapes philippinarum Using High-Throughput Sequencing TBK1 STAT1 BTK PIM1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC3334963__F8 Transcriptomics of In Vitro Immune-Stimulated Hemocytes from the Manila Clam Ruditapes philippinarum Using High-Throughput Sequencing CASP9 FAS TRADD FAIM2 APP PTEN GHITM APIP TRAF2 IRAK4 CIT PMC9234462__F1 Structure Basis of Phytochemicals as Metabolic Signals for Combating Obesity TBK1 TLR4 COCH PMC9240418__F6 Molecular checkpoints of distorted autophagy pathways in lupus nephritis ATG101 ATG3 PINK1 ATG16L1 ATG12 ULK1 ATG14 PARK2 MTOR ATG5 PMC9227157__F3 Does Abiotic Host Stress Favour Dothideomycete-Induced Disease Development? SOS1 FER SOS2 IMPACT PMC8578927__F1 Making a Killer: Selecting the Optimal Natural Killer Cells for Improved Immunotherapies IFNG FAS XCL1 CCL5 PMC4280582__F4 Schematic representation of the HTRA2 protein and its activation against mitochondrial stress HTRA2 PINK1 CDK5 PMC4315929__F7 Cilia assembly and disassembly cycle CEP290 DVL2 CEP97 PLK1 HDAC6 PMC7847503__F7 Summarized molecular mechanisms of the signaling pathway involving the EGFR, TrkB, KRAS HIF-1A and VEGF-A genes; adapted from EGF EGFR ATF4 GRB2 VEGFA BDNF KRAS PMC6582778__F7 Proposed model of F IFNG IL10 ARG1 PMC4718713__F5 Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications BMI1 APC GSK3B TNF CTNNB1 PMC4718713__F6 Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications RNF2 BAX RYBP MDM2 APAF1 FADD PMC2938100__F4 Connections of literature-completed interactome of PI3K-mTOR pathway with other signaling pathways IGF1 RHO MTOR PMC4043666__F7 Mass Spectrometry Based Identification of Geometric Isomers during Metabolic Stability Study of a New Cytotoxic Sulfonamide Derivatives Supported by Quantitative Structure-Retention Relationships F5 F2 F3 PMC3177269__F4 Proposed model for a common symbiotic signaling pathway between actinorhizal plants and legumes NUP133 NUP85 PMC11958682__F2 Rewired amino acid metabolism and FA metabolism in HCC SLC38A11 ACLY ASS1 GOT2 FAS CAD ASL CD36 GPT2 SLC38A1 OTC ARG1 SLC7A5 GLUD1 ACSL1 PHGDH BCAT2 SHMT1 BCAT1 PSAT1 ASNS PSPH PMC4718713__F4 Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications RELA RELB EZH2 SRC PMC11958682__F3 Rewired acetyl-CoA metabolism and redox homeostasis in HCC GLS SLC38A1 HEL-S-64p PMC8024338__F8 MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis CCND1 CDK4 PMC3752952__F1 Pathomechanisms of LN outside the kidney DNASE1 FAS TNFAIP3 RASGRP3 BANK1 CD22 IRAK1 CR2 C4A CR1 STAT1 TYRO3 TLR7 ATG5 FCGR2A CRP IKZF1 SIGIRR CD19 TNF TNLG2B BLK PTPN22 PTTG1 ITGAM C2 FCGR3A STAT4 LYN TREX1 PMC9127837__F5 Mitochondrial DNA Instability in Mammalian Cells OGG1 RAD51 NEIL2 MRE11A DNA2 FEN1 BRCA1 MUTYH NEIL1 EXOG NTHL1 POLE PMC1682009__F1 Activation of the Akt pathway through binding of a ligand to a receptor, tyrosine kinase RHEB TSC2 TSC1 MTOR EIF4E PMC3563611__F8 Candidate miRNAs target genes involved in cell growth, survival, migration, and cell cycle progression PRMT1 CDC42 BAD CRAT HEL-S-28 PTEN CBL BTG1 BTG2 CDK2 PREX2 GRB2 CDK4 PMC4072696__F9 Integrative Identification of Deregulated MiRNA/TF-Mediated Gene Regulatory Loops and Networks in Prostate Cancer CDK2 PTEN MDM2 GRB2 MTOR PMC9334593__F6 Pathway for glycine and serine biosynthesis in CC7-B01 response to heat stress BAD HEL-S-182mP PHGDH HEL-S-61p PSPH PMC4786553__F5 Top networks activated in the CPu during CIE and acute withdrawal SERPINF2 FAS ARHG SLC1A3 PPP1CC CYCS PIK3R1 GPX3 MYC MAPK3 DAGLA KDR HTT GRM3 RGS14 SERPINC1 NTN1 CASP8 CASP2 GDNF SNCA MARK4 B2M PLXND1 MIF PAX6 GRM2 MEF2D HRAS MTDH CACNA2D1 SLC1A2 TENM2 BDNF HOMER2 CP PMC11187922__F9 The main findings in this study MDK MGP MSC SPP1 PMC5793173__F2 Transcription complexes induced by physiological and aberrant Wnt pathway activation APC TBX5 YAP1 CTNNB1 PMC6857109__F1 The E-cadherin (E-cad) interactions and signaling pathway ERBB3 BCL9 EGFR APC ERBB2 CCND1 RAC1 CTNNB1 PMC8429807__F3 Smoking and the Pathophysiology of Peripheral Artery Disease SIRT3 NLRP3 IL13 EIF2A SIRT1 MPO PMC1860037__F1 Role of interleukin 6 in a murine model of Crohn's ileitis: are cytokine/anticytokine strategies the future for IBD therapies? SOCS1 STAT3 SOCS3 GRB2 PMC7606466__F6 RNA-Seq reveals placental growth factor regulates the human retinal endothelial cell barrier integrity by transforming growth factor (TGFB) signaling RAF1 SHC1 SOS1 ITGB4 SMAD2 PML SMAD4 MAPK9 NEDD9 MEF2C ROCK1 APP ZEB2 CCND1 LIMK2 UCHL5 SPTBN1 TGFBR3 ITGB3 YAP1 WWP1 HDAC1 TIEG2 CDKN1A SNW1 STRAP PMC9880437__F1 Pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine NLRC4 GSDMD NLRP3 AIM2 IL1B PMC11352994__F7 Schematic overview of the B7-H4-mediated signalling pathway in trophoblast cells in patients with early-onset PE STAT3 CCND1 PMC5793173__F3 Crosstalk between canonical and alternative Wnt signalling and the Hippo pathway LATS1 MOB1A MOBKL1A LATS2 DKK1 BMP4 LRP5 LRP6 RHO YAP1 PMC8150686__F1 Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research FYN GRB2 PMC4541496__F7 SKN-1 regulation in the GSC longevity pathway NR1C1 KRI1 TFEB GSC PMC6213994__F6 Anti-oxidative signaling and anti-apoptosis signaling pathways BAX KEAP1 PMC8150686__F2 Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research MTOR PMC8446626__F2 Therapeutically Targeting Cancers That Overexpress FOXC1: A Transcriptional Driver of Cell Plasticity, Partial EMT, and Cancer Metastasis FOXC1 HIF1A MTOR CXCR4 PMC8446626__F3 Therapeutically Targeting Cancers That Overexpress FOXC1: A Transcriptional Driver of Cell Plasticity, Partial EMT, and Cancer Metastasis EGF EGFR NFKB1 RELA FOXC1 MTOR PIN1 PMC4552638__F8 Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway TSC2 TSC1 EIF4E PMC7697769__F4A Gene Expression Signatures in AML-12 Hepatocyte Cells upon Dengue virus Infection and Acetaminophen Treatment JUN TIRAP IRF1 IRF3 ATF2 TRAF3 TRAF6 IFNG TLR3 TLR4 TARBP2 TRAF2 TYK2 NFKBIB PMC4829114__F1 Metabolic pathway of P2Y12-receptor inhibitors IL1A ITGB3 ITGA2B PMC8958338__F10 Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications LOX COX1 COX2 PMC8607308__F2 Infection with SARS-CoV-2 shows differential gene expression in Interleukin-6 signaling STAT3 STAT1 CBL PTPN11 IL6ST SOCS3 IL6 JAK1 TYK2 IL6R PMC10340792__F2 Targeting transcription factor YY1 for antitumor therapy EEF2K CD80 FAS PFKP EGFR HSF1 ERBB2 YY1 PMC8762348__F5 NMNAT3 regulating NAD+ in BMSCs to improve mitochondrial function and inhibit cell stress-induced apoptosis SIRT3 PMC4075356__F6 An Irf6-dependent pathway regulating keratinocyte migration IRF6 ARHGAP29 PMC5362152__F7 Schematic representation of the proposed model EGFR PMC6214187__F1 SCAP/SREBPs Are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy ACACB FAS HMGCR EGFR GSK3B LDLR ACACA SIRT1 PMC4259449__F5 Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways TP73 TFRC NUAK1 CDK7 VAMP2 CELF1 NIPAL3 MLKL SETMAR WAS COX7B2 PMC7902504__F1 Kinase pathways mediate dendritic morphogenesis and maturation ABI2 TAOK1 TAOK2 SIK1 DYRK1A ABL2 LIMK1 MARCKS MTOR ARHA AAK1 CDK5 BDNF SEPTIN7 PMC4632006__F1 Left: the PI3K/AKT/mTOR pathway is mainly activated by nutrients (not shown) and growth factors, binding to receptor tyrosine kinases and activating PI3K BMPR2 EIF4B SMAD1 DKFZp781O1323 APC ROR2 PTEN MTOR DEPTOR CTNNB1 EIF4E RHEB TSC2 TSC1 PMC3025834__F1 Schematic representation of xylose metabolic pathway in metabolically engineered S RPE XK XDH PMC3634196__F7 Summary diagram of the proposed mechanisms underlying CA3 hypersensitivity, Alzheimer’s disease protein induction, neuronal death and behavioural deficits following cerebral ischaemia in rats with LTED CA3 JUN BACE1 PMC5403663__F2 Enrichment of gene expression changes (p < 0.05) shared by the TCF4 small interfering RNA (siRNA)#1 and TCF4 siRNA#2 conditions in the “cell cycle” KEGG pathway (p = 0.006, Bonferroni-corrected) DBF4 RAD21 CDC20 CDK7 PCNA SMC3 SMAD4 CDK2 CCL4 MDM2 SKP2 PMC3959159__F1 Major components of the TGF-ß signaling pathway SMAD2 SMAD4 UNK PMC8395387__F2 Pathophysiology of thrombosis in IBD TF VWF TFPI PLG ADAMTS13 PF4 PMC8124719__F9 Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells STAT3 BAX EGFR MDM2 SRC PMC8066561__F1 DNA double-strand break repair mechanisms and PARP inhibitor function BARD1 FANCD2 ATR RAD50 MRE11A BRCA1 CHEK2 CHEK1 ATM PALB2 SSB PMC5033717__F1 Dll4-Notch Signaling in Macrophage Activation NOTCH2 NOTCH3 RBPJ NOTCH1 PMC6385460__F1 The AMPK/mTOR signaling pathway in TNBC tumor growth and progression STAT3 MLST8 ULK1 EGFR MTOR SRC PMC5442421__F1 Simplified scheme of ‘the metabolic map of cancer cell' PCK2 HEL-S-162eP PMC6605314__F10 Schematic model of GPCR-mediated gene expression in neurons DUSP5 ARC EGR2 BDNF CRTC1 PMC4102378__F2 WNT signaling pathway GSK3B HEL-S-28 SRC MYC CCND1 CTNNB1 PMC4049637__F1 Functional Conservation of Coenzyme Q Biosynthetic Genes among Yeasts, Plants, and Humans COQ7 COQ4 PPT1 COQ3 COQ2 COQ9 COQ6 COQ5 PMC8604761__F1 Pyroptotic pathway in immune cells GSDMD NLRP3 RIPK1 TNF IL1B PMC7122831__F2 Terpene biosynthetic pathway in rose-scented geranium IPP ME2 MVD MVK PMC4029595__F7 Proposed breast cancer signaling pathway based on the KEGG network pathway analysis of hypoxia-activated tumor cell migration CDC42 HEL114 PMC10149994__F1 Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses STAT1 MAVS STAT2 IRF9 IRF3 PMC4227541__F2 CD40 stimulation stimulates a highly coordinated immune response by epithelial cells (ECs) NFKBIA NFKBIE NFKBIZ PMC9125181__F7 Endothelial Beta-Catenin Deficiency Causes Blood-Brain Barrier Breakdown via Enhancing the Paracellular and Transcellular Permeability FZD4 PLVAP LRP5 LRP6 CTNNB1 PMC6702836__F6 Partial pathway reconstruction of genes involved in lipids, nucleotides and vitamins metabolism PC DAP PAH CP PMC8094936__F8 Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2 MAVS TANK IRF3 TRAF3 TRAF6 PMC9302637__F2 Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy STAT3 GABRA4 BDNF PMC7580701__F1 Effect of environmental pollution on immune evasion checkpoints of SARS-CoV-2 TMPRSS2 IFNG STAT3 IDO1 AHR FOXP3 ACE2 PMC8478647__F2 External and internal signaling events on the surface of lysosomes RHEB SYT7 NPC1 TFEB CASTOR1 DEPTOR ZKSCAN3 SLC38A9 PMC11893431__F2 Molecular mechanism of SATB1 in breast cancer BRAF MTOR SATB1 TWIST1 PMC6682621__F2 Polyamine metabolic pathway with differential expression genes and reporter metabolites highlighted SMS SRM SMOX PMC5576761__F4 High activity of immune response CENPM CXCL13 CHAF1A CCL3 E2F2 TNFSF6 GZMA ZWINT PSMA4 NUP188 MED31 IFNG PRF1 CDC45 MCM5 PSAT1 SRR SKA1 GINS3 PMC4231066__F6 Ethanol Negatively Regulates Hepatic Differentiation of hESC by Inhibition of the MAPK/ERK Signaling Pathway In Vitro FGF7A HGF CCND1 PMC6046302__F1 MAPK and PI3K/AKT/mTOR pathway interactions in melanocytic tumors GNA11 BRAF PTEN PMC2709380__F7 Hypothetical model of transcriptional regulation of the p21 gene and p53 pathway BCOR SP1 ZBTB2 PMC7254954__F7 PLAG-induced TXNIP and MMP-9 expression in breast cancer cells EGF CBL TXNIP EGFR PMC5701999__F3 Two arms of the insulin signaling pathway in skeletal muscle cells VAMP2 PAK1 STX4A RAC1 PMC9632296__F5 T-cells in head and neck squamous cell carcinoma: From immunity to immunotherapy CDA EGFR PMC11480210__F3 14-3-3 proteins in the TNFR signaling pathway BAX TRADD TRAF1 MTOR PPM1B TNF TRAF2 PMC11480210__F4 14-3-3 proteins in bone biology ACAN COMP COL2A1 PMC6281172__F2 IFN-JAK-STAT signaling pathway BRD4 STAT1 STAT2 IFNAR2 MED14 IRF9 IFNAR1 JAK1 TYK2 BRD2 PMC11480210__F2 14–3-3 proteins in MAPK, PI3K/AKT, TGFB/Smad, Wnt/Beta-Catenin and Hippo/YAP signaling pathway BAX JUN APC TNF CTNNB1 PMC5780129__F7 Co-expression network constructed for the signature genes FCN2 ATXN3 CCDC121 FUS TMEM161A SEC61A1 NXPH4 GPATCH2 STK11 N4BP2L1 SCTR RSRC1 KLHL24 MDFIC RPL38 PCK1 RNP24 INTS7 NELL1 APOA4 BAAT LMO1 SOX14 SHC3 THBS1 MED17 PNMT AMBP TSG101 BTF3 CAPRIN1 GPD1 CTF1 ACSM3 SOX3 MMD PMC7097195__F2 Lysosomes as a therapeutic target TFEB OSTM1 PMC8036789__F4A Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs CXCL12 NGF TRAK1 COX2 TLR4 CX3CL1 PMC6089967__F2 Gene network of the susceptibility pathways/GO terms RYR2 CACNA1A CACNG2 ADRA1A KCNJ4 PLG TRPV1 ASIC4 KCNE2 SCN2B GRID2 FSHR CHRNB4 GABBR1 CHRNA3 SCN2A PRL EDNRB CFTR PMC4510598__F4 Fatty acids biosynthetic pathway (map 61) HEXA FASN PMC7601465__F3 Transforming growth factorB signaling in a nutshell CDC42 TGFBR2 SMAD2 SMAD4 ARHA GRB2 TGFBR1 PMC2807318__F8 Summary of the AMPK and mTOR signaling pathways RICTOR MTOR PMC4650996__F8 TRPV1 antagonist-induced hyperthermia involves BAT-mediated thermogenesis TG TRPV1 UCP1 PMC5836190__F3 Activation of the NLRP3 inflammasome in the canonical pathway NLRP3 IL16 PMC5836190__F5 Alternative pathway of NLRP3 inflammasome activation NLRP3 RIPK1 FADD PMC2896632__F1 Signaling pathway of the KRAS protein EGFR PTEN GRB2 MTOR PMC9316959__F3 Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma BAX MYC TFDP2 PMC9316959__F4 Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma CDC42 BCL9 ADAM17 AXL EGFR SMAD2 SMAD4 ARHA MYC RAC1 CTNNB1 PMC7181582__F6 HIF signaling pathway and upregulated DEGs in HIF pathway from KEGG enrichment analysis of R TF STAT3 HEL-S-133P CYRIA EPO F11 MTOR IL6 VHL TFRC HEL-S-162eP PFKL HEL-S-87p PMC4392244__F9 Comparing CGN death induced by NSC23766 and ToxB CDC42 BAD TRIO TIAM1 PAK1 RHO PMC7967983__F2 Glycolysis in tumor and tumor microenvironment is associated with immunotherapy resistance IRF1 PTEN MTOR CTNNB1 PMC7181582__F7 NFKB signaling pathway and upregulated DEGs in NFKB signaling pathway from KEGG enrichment analysis of R CD40 SYK EGF LTA LTBR TRADD LAT CD14 BLNK TRAF3 TRAF6 DAO LTB CNTF NGF BTK TRIM25 BCR COX2 ATM LYN LBP PMC9316959__F6 Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma G6PC3 GYS1 HEL-S-162eP CS HEL-S-87p PMC3801060__F6 Model of p21-mediated restriction of HIV-1 and related lentiviruses in macrophages PMC5836077__F4 Agrin stimulates integrin-FAK-ILK-PAK1 mechanosignalling pathway to antagonize the Hippo pathway and activate YAP/TAZ mediated gene transcription LATS1 LATS2 PAK1 HEL-S-28 ARHA NF2 PMC8117390__F1 Polymorphisms in MicroRNA Target Sites of TGFB Signaling Pathway Genes and Susceptibility to Allergic Rhinitis HEL-S-62p TGFBR1 PMC2000831__F3 Proliferation induced by androgen independent pathways EGF TGFA PMC6470785__F5 Metabolic and signaling pathway crosstalk in tissues of animals with high inherent aerobic capacity (HIAC) and animals with low inherent aerobic capacity (LIAC) ACLY STAT3 BAX FASN FLT1 IGF1R MTOR SRC PMC5836077__F7 Concerted agrin and YAP activity in the maintenance of NMJs and promoting cardiac regeneration MUSK LRP4 PMC12047509__F1 Nrf2 signaling in Alzheimer's Disease HEL-S-128m KEAP1 GPX4 GCLM NQO1 CX3CL1 BACE1 NOX4 PMC3615883__F1 G1 to S phase cell cycle transition regulators.Abbreviations: S, synthesis; G1, Gap 1 CDK6 SMAD4 MYC CDK4 PMC6935177__F9 Working model demonstrating the regulation of Hippo signaling during ovulation LATS1 LATS2 STAR PMC3069071__F7 Hedgehog Inhibition Promotes a Switch from Type II to Type I Cell Death Receptor Signaling in Cancer Cells BAX SMO PMC12092922__F4 MXRAs is involved in chemotherapy resistance MXRA8 HEL-S-28 MXRA7 SRC PMC5067469__F6 The signaling pathways of pathogen protective mechanisms based on HPCNs in Figure in Mϕs and DCs during Mtb infection TF UBC RPS10 MOS EGFR CS PMC6927934__F6 The cell cycle metaphase checkpoint pathway CDC2 CENPF CDC20 PMF1 RASSF1 CDC6 APC CS PLK1 SKP2 CENPH INCENP CDK2 NSL1 CENPB PMC5940789__F6 MiRNA-gene-pathway network between sixteen intersection genes, and their corresponding pathways and differentially expressed miRNAs HSD3B2 MYLK CASP6 SMAD2 PRKAB2 MMP2 GABBR2 CYP1B1 SKP2 ORC2 PMC12092922__F2 Biological function of MXRAs TIMP1 HEL-S-112 MMRN2 EGFR KIF21A HEL-S-28 CASK IGFBP7 RHO MXRA7 SRC PMC7372205__F1 ACE2/TMPRSS2 pathway and its interaction with SARS-CoV-2 TMPRSS2 ADAM17 ACE2 PMC7372205__F2 COVID-19 early stage pharmacologic intervention targeting Sars-CoV-2 cell entry through the ACE2/TMPRSS2 pathway TMPRSS2 ADAM17 ACE2 PMC7033461__F9 Upregulation of miR-101a Suppresses Chronic Renal Fibrosis by Regulating KDM3A via Blockade of the YAP-TGF-Beta-Smad Signaling Pathway SMAD2 KDM3A TGIF1 YAP1 PMC6307518__F1 HMGB1-RAGE/TLR-TNFA signaling pathway HMGB1 TLR4 SIRT1 PMC10870057__F1 Molecular regulatory mechanism of dormant cancer cells CDC42 RGS2 PCNA APC BMP7 PLK4 CCL5 MTOR BDH2 PMC6333462__F1 Methyltransferases linked to regulation of autophagy BRD4 CARM1 ME2 KAT8 MTOR SKP2 SIRT1 PMC10870057__F2 Molecular regulatory mechanisms of dormant PGCCs CDC42 RGS2 AURKA ATR AURKB SOX2 MYC NR2F1 PMC3298572__F7 Model for HuR NEDDylation NEDD8 RRM1 RRM2 MDM2 PMC4214130__F5 Hypothetical pathway analysis depicts mitochondrial dysfunction PDP2 PDK2 IL1B PMC8721001__F1 Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors SOX9 LEF1 CTNNB1 PMC7675715__F1 Sensitivity of cystic fibrosis transmembrane regulator (CFTR) carriers to COVID‐19 inflammatory response CFTR ACE2 IL1B PMC8721001__F2 Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors CD44 SOX9 PTEN MTOR LEF1 SOX4 CTNNB1 PMC9094400__F1 Targeting PARP1 to Enhance Anticancer Checkpoint Immunotherapy Response: Rationale and Clinical Implications CGAS CCL5 CXCL10 PMC9424672__F5 Cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma CORT CRH TNF PMC5123368__F7 Schematic presentation shows the Adiponectin signaling pathway in neuron under normal (left) and disease (right) conditions APP IRS1 IL1B PMC5016670__F10 Signaling pathway by which TGFB1 increases DNMT1 and DNMT3a GSK3B TGFBR3 PMC9396537__F1 Cardiorenal protection of SGLT2 inhibitors—Perspectives from metabolic reprogramming SIRT3 NR1C1 BDH1 CD36 HEL-S-5 MTOR SIRT1 PMC5993212__F7 Commonalities in epileptogenic processes from different acute brain insults. Does it translate? TSC2 HMGB1 PLCG1 TSC1 IRAK1 MTOR BDNF TRAF6 IRAK4 MYD88 PMC5105987__F11 PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases NRG2 GTF3C5 IGF1 ERBB4 CHPT1 RXRA WWOX GNPTAB SYCP3 PMC5105987__F12 PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases ADRM1 RIMS1 CAMK2A TCOF1 SLC6A3 ERC2 CDX1 CEP78 PMC11468018__F5 Proposed signaling pathway illustrating effects of cancer and inflammation in the kidney TRADD SMAD2 SMAD4 IRAK1 TRAF6 TRAF2 MYD88 PMC7801705__F6 NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease RAB17 NOD2 EEA1 PMC7185074__F6 ‘mTOR signaling pathway’ RHEB SLC3A2 EIF4B PTEN MTOR DEPTOR PMC9396537__F4 Cardiorenal protection of SGLT2 inhibitors—Perspectives from metabolic reprogramming SIRT3 FAS MTOR SIRT1 PMC4055208__F8 Scheme representing the insulin signalling pathway, the mechanisms involved in the high glucose-induced impairment of the insulin pathway and the proposed mechanism by which PPARB agonists prevent high glucose-induced insulin resistance in HUVECs PDK4 IRS1 PMC4774549__F4 Ubiquitination in the Antiviral Immune Response CGAS TRIM32 TRIM56 RNF5 RNF26 PMC4777718__F2 A view of L-homoserine biosynthesis pathway page RAN INA PMC3878307__F1 TMEFF2 AND SARDH COOPERATE TO MODULATE ONE CARBON METABOLISM AND INVASION OF PROSTATE CANCER CELLS GLDC HEL-S-182mP TMEFF2 PMC10940682__F10 Glycosylphosphatidylinositol anchor proteins (GPI-APs) play a role in several cellular signal transduction pathways CD109 STAT3 CD27 FOLR1 TLR4 EGFR SMAD2 CD14 TNF MYD88 PMC4303155__F2 MAPK signaling pathway showing the target genes of microRNAs MAX ECSIT EGF CD14 DAO FLNA PMC11730190__F4 Action of DPEP1 in malignant tumors EGFR MTOR MYC ASCL2 PMC5400654__F1 Involvement of inflammation and its related microRNAs in hepatocellular carcinoma CDH2 SMURF1 SMAD2 VTN SMAD4 ATF2 ZEB2 ARHA RBPJ CTNNB1 PMC9277720__F2 Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers STAT3 STAT1 JAK3 SOCS3 JAK1 TNF TRAF2 PMC5400654__F4 Involvement of inflammation and its related microRNAs in hepatocellular carcinoma LTB CD40 LTBR TRADD RELB TRAF5 TRAF3 TRAF6 TRAF2 MYD88 PMC7226610__F4 P53-related miRNAs controls the osteoblastic differentiation through interplay with Notch, Wnt/Beta-catenin, and Sonic/Hedgehog (HH) pathways JUND FZD2 SOX2 SMO MDM2 VEGFA NOTCH2 RUNX2 LEF1 NOTCH1 CTNNB1 PMC4180468__F10 A model for action of DOX within key signaling pathways necessary for LTF EBP CREB1 PMC3571707__F1 Adaptive Immune Responses and HER2/neu Positive Breast Cancer HMGB1 MYD88 PMC9657949__F1 MicroRNAs in HER2-Positive Breast Cancer: Where We Are and Future Prospective FOXO3A MCL1 IGF2 IRS1 MYBL1 PMC7340853__F1 Clinical promise of next-generation complement therapeutics C6 CD59 FH C7 MASP2 HEL-S-62p C1S C1R CD46 CD55 C4A CR1 MASP1 C5AR2 C9 CP PMC9663521__F7 Protein tyrosine kinase 6 regulates activation of SRC kinase PTK6 EGFR SRC PMC5369246__F1 Signaling pathways of ATM and ATRThe DNA damage response is activated by ATM, ATR, and DNA-PKcs FANCD2 ATR ATRIP RAD51 RAD1 E2F2 E2F3 ATM SSB PMC5369246__F3 STAT-5-dependent activation of ATM and ATR pathways, required for HPV genome amplificationHigh-risk HPV activates STAT-5 to mediate TopBP1 transcriptionally to promote ATR pathway STAT1 TOPBP1 ATR ATM PMC5199628__F1 Principles of Kinase Inhibitor Therapy for Solid Tumors ALK EGFR KIT MTOR RET PMC2563957__F1 Phospholipase A2 (PLA2) catalyzes phosphatidylcholine into AA in response to agonist stimulation of a G-protein–coupled cell surface receptor COX1 COX2 C2 PMC6590704__F1 Nuclear gene-encoded regulatory factors are essential for mitochondrial biogenesis and function TFAM NRF1 SIRT1 PMC3120887__F5 MicroRNA Expression Profiling Reveals MiRNA Families Regulating Specific Biological Pathways in Mouse Frontal Cortex and Hippocampus JUN BAD CRAT DRD3 DRD1 DRD2 MAP2K4 MAP3K1 DRD4 DRD5 NSMAF NCS1 PTH PMC4724176__F2 Molecular signaling and the advantages of Warburg RHEB EGF TSC2 HGF TSC1 PDPK1 HK2 PTEN HIF1A EIF4E PMC7730716__F1 Schematic image of TGFB/SMAD and BMP/SMAD signaling pathway in fibrosis (upper left box, signal activation via TGFB receptor and ligand attachment; orange and yellow circles/arrows, TGFB ligands/signaling and BMP ligands/signaling, respectively) SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC8469693__F5 NFKB and Pancreatic Cancer; Chapter and Verse TRADD RELB TAB3 TLR9 IRAK1 TLR5 IRAK2 TNF IRAK4 TLR4 TLR8 TLR7 REL TRAF2 PMC9503372__F9 Disruption of the Chitin Biosynthetic Pathway Results in Significant Changes in the Cell Growth Phenotypes and Biosynthesis of Secondary Metabolites of Monascus purpureus FAS GIP HEL-S-11 ARL1 PMC7730716__F2 Therapeutic target sites in the TGFB/BMP signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC6679009__F2 Canonical WNT/Beta-catenin pathway DKK1 APC LRP5 LRP6 CTNNB1 PMC8469693__F3 NFKB and Pancreatic Cancer; Chapter and Verse LTB CSA2 LTBR BCR IL16 RELB PMC11965140__F7 Immune regulation of CORT depends on GR signaling and 11Beta-HSD CORT FOXO1 FOXO3A ARG1 MTOR BDNF NR3C1 PMC11889768__F1 Biosynthetic pathway of 2-AP PRODH DAO PMC11965140__F5 Immune activity by CORT through TREM2 CORT SOCS1 STAT3 TREM2 IL10 NLRP3 PLCG2 SOCS3 MYD88 PMC11965140__F6 Multiple pathways mediate the inflammatory injury of CORT induced cell death SOCS1 AXL DLL4 SOCS3 MYC XBP1 MERTK CORT FBXO11 GSDMD NLRP3 TLR4 PROS1 TFEB BCL6 PMC10309559__F2 IFNB expression: focusing on the role of its promoter and transcription regulators TBK1 STAT1 CGAS MAVS STAT2 TRAF6 MYD88 PMC11965140__F3 Immune activation and immune imbalance induced by CORT CORT CD244 CCL22 CCL18 NLRP3 IL33 ATM IFI16 MTOR TREX1 IL1B CCL17 PMC3603375__F4 Neurotrophin signaling pathway is among the pathways downregulated in clinical T1 and upregulated in clinical T2 NGF PENK PMC3894494__F7 Proposed model of heme-induced stasis VWF TIRAP TLR4 CD14 VCAM1 MYD88 PMC3342348__F1 IL-1 signaling in the tumor microenvironment MAP3K7IP1 TRAF6 TNF MYD88 PMC3806061__F1 Diagrammatic representation of the hedgehog (Hh) signaling pathway HHIP BCL2 SMO PMC9093608__F7 Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer’s Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions DPP10 AIP LINGO1 PRNP DOCK2 ACAN SHANK3 UNC5D UNC5B AHI-1 ERBB2 HEL-S-11 NRXN1 PMC10035050__F6 Sodium acetate regulates milk fat synthesis through the activation of GPR41/GPR43 signaling pathway DGAT1 FASN ACACA PMC5468686__F2 Protective or pathogenic roles of innate lymphoid cells (ILCs) in liver diseases CXCL9 STAT3 IL13RA1 APC IL33 FOXP3 IL23R PMC5920772__F3 Development and Connectivity of the Habenular Nuclei DCC SEMA3D SHH SEMA5A PMC11011033__F3 NDRGs in Breast Cancer: A Review and In Silico Analysis SGK1 EGFR PMC8079203__F8 PI3K/AKT/mTOR and autophagy signal pathway MMP2 MMP9 MTOR ATG5 PMC9203688__F1 Ferroptosis and Autoimmune Diseases HMGB1 GPX4 IL6 PMC4988275__F1 Cellular and molecular events of autophagy–lysosomal pathway ATG10 ATG3 ATG12 MTOR ATG5 PMC3684083__F4 EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets EGF TGFA MTOR PMC3684083__F2 EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets SMAD2 BMP2 BRAF SMAD4 MTOR TGFBR1 PMC3684083__F1 EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets EGF TGFA EGFR GHRH BRAF MTOR PMC11821961__F1 Two NFKB signaling pathways include the classical (canonical) and alternative (noncanonical) routes CD40 SYK LTA LTBR TRADD TIRAP LAT RELB IRAK1 BLNK TRAF3 TRAF6 IRAK4 MYD88 LTB BTK MAP3K7IP1 BCR RELA TRAF5 LYN TRAF2 CYLD LCK PMC8602792__F4 Novel Therapeutic Targets in Liver Fibrosis SUFU GSK3B SMO PMC7082882__F3 How PHB1 exerts tumor suppression in the liver MAX CTCF MAF IGF2 PMC7799025__F1 IL-6 receptor and signaling STAT3 TRAF3 GAB2 PMC12160120__F3 Mechanism and effects of the cGAS-STING pathway in regulating antitumor immunity across T cell subsets TBK1 NOS2 CGAS CD27 TNLG8A BATF3 FOXP3 TREX1 KRAS GATA3 PMC12160120__F4 CGAS-STING pathway regulates TAM polarization and anti-tumor immune effect STAT1 CGAS TFEB IRF3 CXCL2 PMC12160120__F5 CGAS-STING interaction network with other immune cells and its regulatory role in tumor immunity SOCS1 CXCL9 STAT3 EEF2K CGAS PC ARG1 CD68 PMC8736280__F1 Vasculopathy in COVID-19 CD59 KLF2 MGRA APC PLG PC CS FDPS CNP CD55 ACE2 RAC1 PMC11899857__F7 NFATc1 plays a central role in regulating the expression of downstream genes and proteins, including CTSK, MMP9, DCstamp, integrin B3, ATP6v0d2, and ACP5 DCSTAMP CTSK ATP6V0D2 NFATC1 MMP9 ACP5 PMC12160120__F6 Interactions and regulatory mechanisms between the cGAS-STING pathway and other components within the TIME CXCL9 STAT3 TBK1 STAT1 IRF3 CXCL10 PMC2082128__F7 Biosynthetic pathway for the ganglio-series of glycosphingolipids B4GALNT1 ST8SIA5 ST3GAL5 ST8SIA1 B3GALT4 PMC12160120__F7 Synergistic Mechanisms and Translational Potential of cGAS-STING Pathway Combined with Other Therapies IRF3 TNF PMC8758994__F1 De novo lipogenesis ACLY ACSS2 FAS CIC HEL-S-26 PMC4703083__F5 The proposed biosynthetic and maintenance pathways for the metallocofactors of the class Ia (a), Ib (b), and Ic (c) ribonucleotide reductases FEV F11 PMC8557169__F4 Turning scientific serendipity into discoveries in breast cancer research and treatment: a tale of PhD students and a 50-year roaming tamoxifen team BAX FADD PMC9497596__F7 Full-Length Transcriptome Sequencing Combined with RNA-Seq to Analyze Genes Related to Terpenoid Biosynthesis in Cinnamomum burmannii IPP ME2 MVK PMC8758994__F3 Physiological regulation of DNL ACLY RFWD2 FAS CIC PMC3929107__F1 Regulation of Hippo pathway and implications for anticancer drug development LATS1 LPA LATS2 SPHK1 RHO PMC12160120__F1 CGAS-STING signaling pathway mechanism TBK1 CGAS STIM1 IRF3 PMC12160120__F2 Mechanisms and Roles of cGAS-STING Pathway in Regulating DC Subpopulations for Antitumor Immunity CD40 CXCL9 TH XCR1 CGAS CD27 TNLG8A PDC CCR7 CCL4 CCL5 CXCL10 PMC4303659__F10 Working hypothesis for how the PGRN/PIRO axis regulates the formation of multinucleated osteoclasts OSCAR NFATC1 TRAF6 PMC2390572__F10 MCF10A Pathway 2 affected by TFIIS knockdown ATF5 PLD2 METAP2 SHC2 GNG3 INSIG1 SLK LTB4R GNB1 PVALB IL24 PPP1R15A ACADVL PMC6054955__F4 Immune Responses of Epinephelus coioides to sigX CD40 C6 ICOS IL10 C7 BCR CXCR4 PMC8466051__F2 VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles VAV1 RBPJ NOTCH1 PMC8070086__F6 Putative mechanisms of TRIB3-mediated AKT signaling inhibition MLST8 BAD RICTOR MTOR TRIB3 PMC4363166__F4 An extended signaling pathway that regulates basal P-glycoprotein activity at the blood-brain barrier S1PR1 MTOR PMC11465851__F3 Pattern recognition receptors on ependymal cells are involved in inflammatory signaling The TLR4/MyD88/NFKB signaling pathway induces the release of inflammatory cytokines like IL-1B and TNFA, while promoting phagocytic apoptosis FOXJ1 TLR4 TLR9 CD14 TNF MYD88 PMC6679009__F5 Beneficial role of NSAIDs in cancer process STAT3 BAX APC GSK3B TNF PMC6562376__F1 B1 integrin induces EGFR- or HER (ErbB2)-targeted therapy resistance EGF EGFR NRP1 ERBB2 SRC PMC6562376__F3 B3/KRAS/RalB/NFkB pathway mediates EGFR-targeted therapy resistance EGF RALB EGFR KRAS PMC3649103__F2 Hepatic ethanol metabolism LPL TG FAS HEL-S-70p IRS1 PMC9501546__F5 TTYH3 Modulates Bladder Cancer Proliferation and Metastasis via FGFR1/H-Ras/A-Raf/MEK/ERK Pathway HRAS FGFR1 TTYH3 PMC3763909__F2 The role of androgens/AR in acne formation/progression IGF1 FOXO1 PMC3649103__F1 Hepatic glucose metabolism TG FAS FOXO1 APOB IRS1 PMC8976637__F2 Disease: Recessive ADAMTSL4 Mutations and Craniosynostosis with Ectopia Lentis FBN1 CS SKI PMC8427595__F7 Dengue Virus Dysregulates Master Transcription Factors and PI3K/AKT/mTOR Signaling Pathway in Megakaryocytes GATA2 TPO MTOR PMC8938628__F12 Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting Beta-catenin/TCF4 signaling pathway BCL9 APC GSK3B LRP5 LRP6 TCF4 CTNNB1 PMC3429047__F5 Simplified illustration of the canonical Wnt signaling pathway APC LRP5 LRP6 PMC2747168__F1 Acp-group transfer catalyzed by PhTYW2 TYW3 TYW1 PMC8863366__F1 Blocking cholesterol storage to treat Alzheimer’s disease NPC2 ACAT1 NPC1 APOE ABCA1 PMC7249037__F5 KEGG pathway for ovarian cancer TH SIL1 MME LAT ATM CS MYC RORA PMC7249037__F6 KEGG pathway for colorectal cancer BAX CASP9 JUN DCC BAD POLK EGFR APC CASP3 SMAD4 AREG MTOR PMC5743003__F1 Signaling pathways involved in the pathogenesis of MPNs and secondary AML MPL TET2 HEL-S-99n EPOR ASXL1 EPO EZH2 TPO MDM2 GRB2 MTOR PMC7249037__F7 KEGG pathway for breast cancer RAN PTEN SHE POLE PMC3107100__F1 Genetic alterations in glioblastoma signal transduction pathways (adapted from Parsons et al) NF1 EGFR TP63 PTEN CDKN2B MDM2 SRC PMC9961805__F1 E’Jiao on Skeletal Mineralisation, Osteocyte and WNT Signalling Inhibitors in Ovariectomised Rats SOST APC LRP5 LRP6 PMC3868343__F2 Molecular basis for synergistic activation through pairs of coactivation receptors on NK cells SYK CBL FYN PMC9030606__F1 Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies TH MAVS NLRP3 NOD2 IRF3 IRF7 MPC1 JAK1 ACE2 HDAC2 TYK2 PARP1 PMC10814280__F1 RABV-induced incomplete autophagy ATG3 CASP2 ATG12 ULK1 IFITM3 PMC10221447__F3 Natural Products Targeting PI3K/AKT in Myocardial Ischemic Reperfusion Injury: A Scoping Review BAX TNF PMC3907121__F1 Cardiovascular Effects of Erythropoietin: An Update STAT3 BAD BCR EPOR EPO GRB2 PMC2917029__F8 Molecular pathway initiated by P4 signaling in BPBC cells EGF EGFR PTEN PMC8018074__F8 Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/B‐catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide MBP APC GSK3B OLIG2 TCF4 SOX10 OLIG1 AXIN2 IL1B CTNNB1 PMC3667241__F1 Schematic drawings of the neuronal signaling pathways of anorexigenic and anxiogenic-like action in goldfish GNRH2 CCK CRH NMU PMC7675040__F4 Alteration in DNA repair mechanism in esophageal cells chronically treated with cigarette smoke condensate TP73 ATR PCNA CLSPN EZH2 MED1 TNFRSF10A MGA EVL PRKDC CHEK2 CDK2 ATM CCNK PMC11593047__F3 Contribution of Sox17-induced gene products to the maintenance of the hematopoietic capacity and cluster formation SOX17 GATA2 ESAM GATA1 RUNX1 SMAD2 GSK3B SOX18 SOX7 HES1 NOTCH1 TGFBR1 PMC3432190__F2 Concept of molecular network in schizophrenia CDC42 KLF4 TH EGF ASS1 ASL ALDH18A1 PLSCR1 EGFR LRAT ARF6 PLA2G1B NTRK3 TCF4 MYC ADH1A ALDH2 NGF PLCG1 PRKCA PC SRC HEL-S-36 CAD PLD2 IL4 ARG1 PTGS2 VEGFA DDC SCGB1A1 HDC ACTN4 POLR3C PRODH BDNF PMC10421513__F10 Structure Characterization and Immunomodulatory Activity of Misgurnus anguillicaudatus Carbohydrates ECSIT JUN MAP3K7IP1 TIRAP TRAF6 MYD88 PMC6479730__F1 General representation of the signaling pathways involved in the antagonism of both ionotropic and metabotropic glutamate receptors in anti-cancer mediated effects SMAD1 DKFZp781O1323 MTOR PMC8238076__F5 Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation TBX2 ATF3 CDKN2A DOCK8 TREM1 GNE AURKB NUMB AREG ASXL2 MEF2D PMC8238076__F6 Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation ATR WEE1 MYT1 PMC6792082__F7 Targeting NRF2 antioxidant pathway for IDH1-mutated cancers KEAP1 GCLM GCLC MAF ME1 PMC10373932__F5 Insights into the physiological and genomic characterization of three bacterial isolates from a highly alkaline, terrestrial serpentinizing system AMT PMC8161999__F6 Identification of circRNA–miRNA–mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer MAX SYK MYB MAFK BAD FAS TRADD EBP APMAP RBL2 CD19 DAO TSC2 MEI1 PC SI APP HP POLE PMC11555182__F1 KEAP1-NFE2L2 signaling pathway RBX1 KEAP1 NFE2L2 PMC11711403__F9 Model depicting PBLD and Cedrelone inhibit viral replication via activating the NFKB-mediated IFN-I signaling response HEL-S-306 IRF9 TRIM21 PMC9160962__F1 Methyl Metabolism and the Clock: An Ancient Story With New Perspectives GLDC DHFR SLC46A1 MTRR TYMS HEL-S-51e ADI1 FTCD AMD1 SLC25A26 SRM SHMT1 MTHFD1L MTHFD2L SLC25A32 MTHFS FPGS MTHFD2 MTFMT SMS ENOPH1 CTH AHCYL2 SLC19A1 HEL-S-70p MTHFD1 ALDH7A1 FOLR1 BHMT2 CHDH DLD HEL-S-61p APIP MTR MAT1A PMC9355787__F1 COL1A2, AKT3 genes, and related signaling pathway in the pathology of congenital talipes equinovarus COL1A2 AKT3 GSK3B MTOR PMC3287489__F2 Cell cycle pathway and the significant genes on cell cycle-related miRNAs CDC20 CDK7 PCNA CDK2 MDM2 SKP2 PMC3978385__F3 NRAS mutant melanoma: biological behavior and future strategies for therapeutic management BRAF GRB2 PMC3787923__F2 The role of chemotherapy and latest emerging target therapies in anaplastic thyroid cancer MAPK1 EGFR PTEN MTOR PMC11555182__F2 NFE2L2-dependent genes in ferroptosis SLC3A2 ABCB6 SLC40A1 AIFM2 GPX4 MGST1 FACL4 SLC7A11 FECH HERC2 HMOX1 FTH1 TFRC FTL NQO1 PIR NFE2L2 MT1G HEL-S-64p HEL-75 PMC8144126__F9 Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease TG NR1C1 TLR4 CD14 MYD88 PMC5007850__F7 Diagram summarizing the proposed mechanism by which MACC1 drives resistance to trastuzumab MACC1 HEL-S-133P HK2 PMC6372189__F3 A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster ALOX5 ALOX15 ALOX12 ALOX15B PMC8640456__F3 An Integrated Analysis Reveals Geniposide Extracted From Gardenia jasminoides J.Ellis Regulates Calcium Signaling Pathway Essential for Influenza A Virus Replication PLN CAV3 CAV2 HRC BCR MCU PMC5689670__F8 Baicalein inhibits progression of osteosarcoma cells through inactivation of the Wnt/Beta-catenin signaling pathway BAX CCNE1 MMP2 MMP9 CDK4 CTNNB1 PMC6923843__F5 Gene functional and Network pathway analysis of TRAP1, HSPD1, HSPB1, HSPA1L and HSPA1A HSPD1 HEL-S-102 PMC9032823__F7 Metabolism of the Genus Guyparkeria Revealed by Pangenome Analysis HEL107 RPE PMC3627964__F2 Proposed roles of Msi1-like (MSIL) proteins as regulators of the nutrient- and stress-sensing signaling pathways in fungi CDC42 MSI1 MSL1 PMC8250137__F3 COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and Mortality STAT3 AK1 LEPR IRS1 PMC4095859__F3 Metabolic requirements for the maintenance of self-renewing stem cells FASN PML MTOR PMC5668879__F10 Proposed effect of polyP and retinol on the expression of the fatty acid binding protein 4 (FABP4) and leptin/leptin receptor RAF1 FOXO1 DLL4 FABP4 HEL-S-4 MTOR VEGFA PMC4095859__F4 Metabolic requirements for the maintenance of self-renewing stem cells CRIPTO ATM MTOR PMC3061506__F1 Integration of the identified proteins into the canonical pathway of TLR signaling JUN PMC9202997__F3 Impact of Air Pollution on the Course of Cystic Fibrosis: A Review PROX2 HMOX1 BAX NPS BAD ASL ATM CFTR PMC3626841__F4 Original model by Neumann et al CASP8 CASP3 FADD PMC2667788__F3 Paracrine mechanisms in adult stem cell signaling and therapy RAMP3 STAT3 BAX BAD RAMP2 HGF IGF1 WNT3A EPO HEL-S-28 IL11 CTNNB1 PMC5716829__F1 Different PPGL molecular subgroups with corresponding driver mutations and a proportion of hereditary disease in the respective cluster MAX FH MTOR MYC SDHAF2 CSDE1 VHL SDHD HRAS SDHA SDHB TMEM127 MAML3 NF1 SDHC RET PMC7576599__F1 Emerging role of the Hippo pathway in autophagy ATG101 ATG3 ATG16L1 ATG12 ULK1 WIPI2 ATG14 PMC10373173__F2 Matrix metalloproteinases in rheumatoid arthritis and osteoarthritis: a state of the art review MYC TNF PMC6428091__F1 Cytosolic glucose enters glycolysis and pentose phosphate pathways LPA FAS GLA PEX10 PEX3 GPD1 TNLG7C PMC8360179__F5 Plastidial acyl carrier protein Δ9‐desaturase modulates eicosapentaenoic acid biosynthesis and triacylglycerol accumulation in Phaeodactylum tricornutum LPA tmp_locus_29 HEL-S-5 PC PMC5678884__F9 Kojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus CDC42 PMC4810057__F2 The signaling network of JAK/STATs in IBD STAT3 STAT1 STAT2 JAK3 STAT4 JAK1 TYK2 PMC7359838__F1 Spliceosome pathway (hsa/dre03040) as enriched in module ME01 (Bonferroni correction < .05) AQR RBM22 CHERP ISY1 SNRNP27 NHP2L1 SLU7 PUF60 MAGOH PMC11595780__F4 Intratumoral microbiota promotes tumorigenesis and tumor progression through several mechanisms STAT3 CTNNB1 PMC6209728__F2 Osteocyte role in MM bone disease CCL3 LRP5 LRP6 TNF PMC10814280__F2 : promotion : inhabition BAX GPR17 BCL2 PMC7588592__F2 New molecular targeted drugs VIP EGFR PMC6770025__F1 Synthesis of steroid hormones in humans POR HSD3B2 CYP21A2 SRD5A2 STAR CYP17A1 HSD17B1 HSD17B2 PMC4184910__F1 Schematic diagram and proposed model for the metabolic regulation and coordination of the leptin mediated reproductive and nutritional axes IGF1 INSR LEPR POMC MC4R NPY ARC AgRP PMC9688847__F1 Stemness of Normal and Cancer Cells: The Influence of Methionine Needs and SIRT1/PGC-1A/PPARA Players GLDC MTAP SMS SRM SHMT1 MTR HEL-S-51e PMC5649203__F2 Metabolic requirements of effector CD8+ T cells (Teff) CD36 MTOR CPT1A PMC9412206__F1 Left ventricular noncompaction: a disorder with genotypic and phenotypic heterogeneity—a narrative review BMP10 IRX3 HEY2 TBX20 ERBB4 MIB1 PRDM16 INO80 EPO NUMB TBX5 YY1 NOTCH2 NRG1 RARA SEMA3A SLIT2 NPPA EPOR FKBP1A ERBB2 JARID2 PMC4995918__F2 mf regulated mTOR signaling pathway in human DC RPS6 EIF4B MTOR RHO IRS1 EIF4E RHEB TSC2 RICTOR TSC1 INSR PC ELF3 PMC12149389__F9 CMTM7 inhibits TLR4 signaling pathway via promoting Rab5 activation and alleviates acute liver injury HMGB1 CMTM7 TLR4 MYD88 PMC11992894__F9 General schematic view of enzymatic browning (EB) in apple pulp and proposed pectin-related signaling pathway MYB ERF PMC8295688__F1 Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 Infection TMPRSS2 IFNG GSDMD NLRP3 ACE2 IL1B PMC7215355__F1 Lipid metabolic processes during HCV RNA replication, assembly, and egress OSBP CIDEB MTTP SCD APOE PC RAB18 PMC4938033__F3 Enhanced Ca2+ and ROS levels in cardiac hypertrophy RYR2 PLN GATA4 PMC3707373__F1 Regulation of Th9-Type Pulmonary Immune Responses. A New Role for COX-2 IL25 IL17RB PMC7076221__F8 Working model for protective effects of SIRT1 via HAS2–AS1 and NFKB COCH HAS2 SIRT1 PMC10747773__F4 HCV-induced ROS/JNK/Itch signaling pathway promotes VSP4A polyubiquitylation, leading to enhancement of VPS4A ATPase activity, thereby upregulating the release of HCV particles ITCH CHMP1B VPS4A PMC3757331__F8 Revisiting MPF activation CDC2 ARPP19 MOS MYT1 PMC3582273__F1 CluePedia analysis example using expression data from human normal colon mucosa and colorectal tumors and in silico information SOCS1 IFNGR1 PDE6C PTPN1 PTPN11 B3GALT2 IL17A SOCS3 PTPN6 IFNG ICOS STAT1 IFNGR2 SUMO1 MADCAM1 LAP3 PDCD1LG2 CX3CL1 PIAS1 NPTN CYP2C8 VCAM1 JAK1 PMC3836209__F1 Metabolism of adenosine PNP ADA PMC6357837__F7 Working model of cholestasis in Pemt+/+ and Pemt–/– mice fed the HFD ATP8B1 PEMT PC PMC7806659__F10 The proposed hypothesis model showing that miR-148a-3p positively regulates neuronal apoptosis via activating the PI3K-AKT signaling pathway by targeting SYNJ1 CASP9 BAD SYNJ1 MTOR PMC5742211__F1 Simplified pathway of de novo sphingolipid synthesis SPHK2 tmp_locus_29 SPHK1 PMC6468702__F3 Sub-genomic flavivirus RNAs (sfRNAs) impair cellular response to viral infection XRN1 TRIM25 G3BP2 PMC5652078__F2 HR+, HER2– Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles CDK6 MTOR CDK4 GATA3 PMC4588911__F1 IL-33/ST2 signaling pathway in mast cells IL33 IRAK1 TRAF6 IRAK4 MYD88 PMC9448875__F7 Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway CDC42 NOD1 CCL2 CCL1 PMC9533135__F8 Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells IDE SOX2 FGF5C FGF10 PMC6473623__F1 Autophagy-A highly conservative cascaded regulatory mechanism upholds the intracellular homeostasis of the biological system WIPI1 NBR1 LAMP2 ATG10 ATG3 ATG12 BCL2 MTOR STX17 ATG5 PMC2999341__F12 Regulatory PathRNet Only nodes that are close to P38 MAPK Signaling pathway or "S-7" are kept (distance<3) C7 HEL-S-62p C2 PMC6473623__F2 Autophagy Intertwines with Different Diseases MEFV ATG16L1 ULK1 HSBP1 TUFM AIM2 ACD DVL2 SAFB2 STX17 WIPI1 ATG10 LAMP2 SYNPO2 ATG3 WDFY3 ATG12 TRAPPC12 ATM BMF ATG5 PMC7352608__F2 Therapeutic approaches of splicing modulation in cancer SF3B1 U2AF2 U2AF1 PMC5818153__F1 Sphingolipid metabolism in cancer signalling and therapy CERS3 CERS5 CERK SMS CERS1 CERS2 SPHK1 SMPD1 CERS6 SPHK2 tmp_locus_29 PC SPTLC1 PMC2921082__F1 Adenosine monophosphate-activated protein kinase pathway in hepatic fuel metabolism TSC2 TSC1 MTOR IRS1 PMC9473879__F9 Network Pharmacology and Experimental Verification Revealed the Mechanism of Yiqi Jianpi Recipe on Chronic Obstructive Pulmonary Disease STAT3 JUN EGFR FOS H1-0 PMC2921082__F4 Dual regulation of fuel metabolism and cell viability by adenosine monophosphate-activated protein kinase TSC1 GSK3B MTOR IRS1 PMC5863198__F1 All roads lead to Rome: vascular inflammation NLRP3 RAC1 IL1B PMC4722285__F6 Schematic model of downstream signaling after GPCR activation PLCG1 GIP RAC1 PMC3096079__F1 mTOR regulation pathway involved in hypoxia EPO MTOR VHL EIF4E PMC9408823__F8 FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer’s Disease CDC2 STAT3 RPS6 PXN GSK3B MARK1 IRS1 STAT1 CBL CDK5 FYN INSR PDPK1 ABO SRC HEL-S-15 PMC8231806__F6 Dietary Curcumin Alleviated Acute Ileum Damage of Ducks (Anas platyrhynchos) Induced by AFB1 through Regulating Nrf2-ARE and NFKB Signaling Pathways NLRP3 KEAP1 TXNIP GCLM TLR4 NQO1 GCLC RELA PMC6770582__F6 Schema of the present study FUT4 CPNE8 PRSS1 NOL4L BHLHE41 PMC7551072__F1 Regulation of metabolism by B vitamins DHFR HEL-S-61p PMC8800364__F5 Immunometabolism in biofilm infection: lessons from cancer CD40 NOS2 VEGFA PMC4125180__F8 Profiling of Luteal Transcriptome during Prostaglandin F2-Alpha Treatment in Buffalo Cows: Analysis of Signaling Pathways Associated with Luteolysis BAX STAR BCL2 SRC PMC8800364__F7 Immunometabolism in biofilm infection: lessons from cancer STAT3 NR1C1 CD36 TNF PMC7281690__F1 Role of WNT/TGFB signaling pathways in pathogenesis of cardiac fibrosis TGFBI SMAD2 APC SMAD4 TGFBR1 PMC4125180__F3 Profiling of Luteal Transcriptome during Prostaglandin F2-Alpha Treatment in Buffalo Cows: Analysis of Signaling Pathways Associated with Luteolysis RYR3 MT2A TNFRSF12A GEM RHOB CD14 IGFBP2 ARG2 PMC9379405__F7 Intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways SMAD1 DKFZp781O1323 SMAD6 SMAD4 PMC7281690__F2 Crosstalk between microRNAs and WNT/TGFB signaling pathways in cardiac fibrosis STAT3 TGFB1 PTEN IL6 RHO TGFBR1 PMC4956099__F8 ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle XPA DDB2 ATR ATRIP ATM XPC PMC9379405__F5 Intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways CCND3 NEDD4 NUMB FURIN HES1 HES5 PMC9379405__F6 Intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways JUN APC GSK3B LRP5 LRP6 NR1C2 MTOR MYC RAC1 CTNNB1 WLS BCL9 MAP3K7IP1 RNF43 ZNRF3 NLK GPR49 CYLD CCND1 LGR6 PMC5566524__F9 TF-FVIIa-dependent PAR2-activated signaling pathway that accounts for Beta-catenin accumulation and expression of metastatic proteins leading to enhanced migration and invasion of human breast cancer cells TF APC GSK3B CTNNB1 PMC7525004__F3 Genetic and pharmacological activation of Wnt/Beta-catenin promotes neurogenesis in the hippocampus of AD models NEUROD1 WNT3A APC GSK3B LRP5 LRP6 WNT3 CCND1 CTNNB1 PMC8169867__F8 EGFR-HIF1A signaling pathway in Th9 cells NOS2 TSLP EGFR HIF1A PMC9633314__F5 Fibroblast growth factor receptor 3 overexpression mediates ALK inhibitor resistance in ALK‐rearranged non–small cell lung cancer ALK FGFR3 EML4 PMC7289676__F1 ACE2, COVID-19, and ACE Inhibitor and ARB Use during the Pandemic: The Pediatric Perspective ATR ACE2 PMC7102037__F2 Hyperglycemia-induced lung diseases STAT3 ASL RHO PMC3974425__F5 Ezrin expression and cell survival regulation in colorectal cancer BAX EGF JUN DCC MMP14 ARHG TNFRSF1A PTGS2 MMP9 ARHA FOS RAC1 CTNNB1 EZR BCL2L1 MMP2 SRC PMC3932036__F5 Akt signaling pathway RHEB TSC2 BAD TSC1 HEL-S-28 PTEN CDC37 GRB2 MTOR EIF4E PMC8771160__F8 Pyridinium-type fullerene derivative suppresses primary effusion lymphoma cell viability via the downregulation of the Wnt signaling pathway through the destabilization of Beta-catenin JUN APC GSK3B TCF4 MYC CCND1 PMC2742090__F4 Negative feedback loops in the SHH signaling pathway driven by SHH-binding proteins BOC SHH GAS1 PMC9175009__F2 Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics GSDMD NLRP3 PTMS TRIM65 IL1B FADD TRIM21 MYD88 PMC2709066__F1 De novo purine synthesis pathway PFAS ADSL PMC10177184__F6 Evolutionary chart of human molecular pathway Akt GATA2 WNK1 SYK BAD PTK6 TIRAP ITGB1BP2 GSK3B DBT PTEN IGF1R PDK2 MTOR MYD88 LY96 PHLPP1 TLR4 MDM2 SRC CCND1 RPTOR SGK1 ACIN1 CD19 MLST8 TSC2 HBEGF TSC1 GSK3A BCAP31 BRCA1 FOXO1 RS1 CDC37 GRB2 GAB2 TBC1D4 PMC11027554__F2 "hit and run" mechanism posits a potential role for H ADAM17 BRCA1 SRC CTNNB1 PMC10177184__F7 Evolutionary chart of human molecular pathway of EGFR signaling (A), Notch (B), and Hedgehog (C) pathways EGF EGFR MAP2 RHO RAC1 CBL MAP3K1 PAK1 SUFU CSK MUC1 SMO MAP2K1 GRB2 JAK1 USP6NL SRC PMC5463383__F7 Proposed model showing the mechanism of action of PPARG agonists (TRG and RSG) on TGFB1-induced fibrogenic activation in human primary intestinal myofibroblasts SMAD2 SMAD4 PMC8833361__F8 Time Series Ovarian Transcriptome Analyses of the Porcine Estrous Cycle Reveals Gene Expression Changes during Steroid Metabolism and Corpus Luteum Development TH HHIP ARRB2 PTCH2 BCL2 SMO HEL-S-11 HP KIN PMC10177184__F9 Evolutionary chart of human molecular pathway of WNT signaling MMP7 ENC1 FRZB NRCAM APC GSK3B LRP5 NR1C2 ARHA RAC1 COX2 CCND1 CLDN1 WIF1 PMC3075371__F1 Local control of Beta-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient INA HEL-S-11 PMC3407375__F3 MicroRNA Circuits in Transforming Growth FactorB actions and Diabetic Nephropathy USF1 YBX1 ZEB2 MDM2 PMC6753331__F1 MiR-155 is expressed in plasma (P), monocytes, fibroblast-like synoviocytes (RASF) and synovial fluid monocytes (SFCD14*C) of patients with RA/JIA SOCS1 STAT1 TLR4 IRAK1 IRF3 TRAF6 APAF1 CASP10 PMC7797856__F5 Six core genes (COMP, SPP1, COL1A1, IL6, VWF, TEK) were significantly enriched in the PI3K-Akt signaling pathway SYK EIF4B BAD RBL2 PTEN CD19 MTOR IRS1 EIF4E TSC2 BOLL TSC1 BRCA1 BCR CDC37 MDM2 GRB2 CCND1 PMC8375323__F9 TIMM17A Regulatory Network Contributing to Breast Cancer DLGAP5 CDC20 ANAPC7 NCAPG HMMR MYBL2 CDC6 NEK2 CENPE CCNA2 PLK1 BLM KIF23 FOXM1 BIRC5 CCNE1 KIFC1 CCNB1 TOP2A NUP133 CDC2 NUCKS1 E2F2 DTL RRM2 EZH2 TROAP MAD2L1 TBCE PAICS SPC25 TK1 CHEK1 MCM2 UHRF1 HCTP4 NCL PMC3466334__F3 Genetically-defined metabolic reprogramming in cancer FH KEAP1 HEL-S-26 PMC7227004__F1 YAP/TAZ activity is tightly regulated—Hippo signaling and beyond LATS1 LATS2 EGR1 CBFB ERBB4 EGFR RUNX2 RUNX3 PMC3466334__F1 Genetically-defined metabolic reprogramming in cancer PHGDH MAL CIT PMC3974514__F1 Metabolic pathway of azathioprine/mercaptopurine metabolism TPMT PMC8375323__F4 TIMM17A Regulatory Network Contributing to Breast Cancer TIMM17B SLC25A4 TIMM22 ATP5G1 GRPEL2 DNAJC19 TIMM17A C18orf55 PMC6723645__F1 Pathway inhibition by targeted agents and their effects on cell proliferation, apoptosis, metastasis and angiogenesis JUN SOS1 GRB2 MYC FOS PMC2871922__F4 Regulation of spermatogenesis processes by non-classical testosterone signalling EGFR FSHR PMC2574672__F2 Iron–sulfur (Fe-S) cluster biogenesis in eukaryotes NUBP1 FDXR FXN ISCU ABCB7 FES CIAO1 NUBP2 NARF HSCB PMC4530367__F1 Alternative pathway of the complement system.The activation of the alternative pathway of the complement system depends on spontaneous hydrolysis of complement factor 3 (C3) in plasma leading to the formation of C3(H2O) C6 FH C7 HEL-S-62p C9 PMC5633564__F1 Folic acid and the one carbon cycle (1-CC) PMC6900372__F4 The results of pathway enrichment analysis TEC JAM2 ARHH ITGAM VASP ITGA4 THY1 ARHA CXCR4 JAM3 RAC1 CD99 PMC5363986__F1 The Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt APC GPR49 HES1 PMC7767525__F1 Summary of the activity of FANC proteins in the FA/BRCA pathway ATR REV1 ID2 BRCA1 USP1 FANCM RFWD3 FAAP24 SLX4 PMC7767525__F2 Major mechanisms of double-strand break repair FANCD2 CYREN RAD51 HMCES POLE PARP1 PMC9233184__F1 Complex relationship between integrins and oncolytic herpes Simplex Virus 1 in high-grade glioma therapeutics STAT3 CYR61 TGFB1 EGFR TET3 HEL-S-28 GSC HIF1A SRC CTNNB1 PMC2940983__F1 Histone GH2AX and Poly(ADP ribose) as Clinical Pharmacodynamic Biomarkers ATR BRCA1 H2AX ATM MDC1 PMC8015888__F8 Immune detection, inflammatory signaling and intracellular fate of MVs produced by Gram‐positive bacteria TLR9 TLR8 NOD2 TLR7 CCL2 PMC4598198__F2 effect of lipoxins on cytoplasmic signaling cascades and transcription factors.Notes: Lipoxin binds to its G protein-coupled receptor ALX/Formyl peptidyl receptor triggering a wide array of cytoplasmic signaling cascades EGR1 NAB1 MTOR TNF MPO PMC11872610__F1 Design and preparation of Qu-CDs for the treatment of burn wound healing CDH2 SMAD1 DKFZp781O1323 ID2 ID4 ARG1 ID1 ID3 PMC5862596__F1 Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas FAS HEL-S-162eP EGFR PMC9287179__F8 Mechanism of the ANKFN1 gene in HCC CDK6 PCNA ARHA GRB2 CCND1 CDK4 PMC10537516__F1 IL-15 and N-803 for HIV Cure Approaches JAK3 PTPN1 SOCS3 JAK1 IL15RA PMC2836046__F7 Proposal of the regulatory loop of miR-24, miR-34a, and HNF4A in bile acid synthesis CYP8B1 CYP7A1 CYP27A1 PMC8997790__F3 Vitamin D and Hypoxia: Points of Interplay in Cancer NR1i1 RHEB TSC2 TSC1 PLK3 DDIT4 PTEN HIF1A EIF4E PMC5520163__F1 How the MyD88 pathway triggers the ubiquitylation of IRAK1 IRAK1 TRAF6 IRAK4 MYD88 PMC3850498__F1 Inhibition of the mevalonate pathway to override chemoresistance and promote the immunogenic demise of cancer cells PGP IPP IL18 HIF1A ARHA PMC12037491__F7 Possible mechanism of central tolerance of thymic T cells induced by H ZAP70 CHMP5 APC GRB2 TRAF6 PMC6785648__F1 Important factors involved in the pathogenicity of septic shock caused by LPS from gram-negative bacteria TF HMGB1 TLR4 LDLR IRF3 PLTP LBP PMC8569819__F8 TNF signaling Kegg Pathway report for up-regulated DEGS caused by WYE (Low) 15 μg/ml vs. untreated controls after meeting selection criteria; -2+2 fold change, p-Value <0.05 and FDR p-Value <0.05. Up-regulated DEGS are demarcated by a red star CIC ITCH EDN1 HEL-S-11 TNF FADD PMC3050939__F3 Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis GGPS1 RABGGTB MVK HMGCS1 IPP HMGCR PMVK MVD DHCR7 FDPS IDI1 FDFT1 PGGT1B PMC3328748__F11 The molecular players involved in angiogenesis signalling mediated by the interaction of VEGF-A with VEGFR-2 RAF1 GRB2 SHE PMC6461577__F8 Fludarabine Improves NDV-Mediated Oncolytic Viro-immunotherapyOn the one hand, the viral RNA activates the cytoplasmic RIG-I signaling pathway in the host cells to produce type I IFNs or other antiviral molecules STAT3 STAT1 MAVS IDO1 IFNAR1 IRF3 IRF7 PMC7460249__F1 Metabolic reprogramming in cancer GOT2 FAS CD36 HEL-S-5 MYC KRAS PMC2737689__F2 Multiple isoforms catalyze each step in the glycerol-3-phosphate pathway of TAG synthesis LPA AGPAT5 HMFN0839 ACSL1 DGAT1 GPAT4 GPAT2 DGAT2 AGPAT3 AGPAT4 PC PMC2889025__F2 P53 stabilization ATR ATM MDM2 MYC PMC2907396__F3 Genome-Wide Expression Profiling Deciphers Host Responses Altered during Dengue Shock Syndrome and Reveals the Role of Innate Immunity in Severe Dengue JUN CBL FYN NFATC2 LAT RELA NFATC3 GRB2 PMC8646611__F5 Rapid Detection and Inhibition of SARS‐CoV‐2‐Spike Mutation‐Mediated Microthrombosis SP1 HRG F13A1 IL6 FURIN CCL2 ITGA2B ALB HMOX1 TLR4 APP FGA CXCR4 SELP PMC2907574__F4 Inhibition of host signalling pathways by VACV members of A46 and related families TBK1 TIRAP TLR9 IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 MAP3K8 TLR1 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC2889025__F1 Response of p53 to DSBs generated by ionizing radiation BAX ATR CDC45 CDK2 ATM MDM2 PMC5825991__F2 Targeting pattern-recognition receptor signaling in human intestinal inflammation RP1 TBK1 TLR1 TLR9 IRAK2 PMC3983064__F9 Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation SYK TLR9 NOD2 TNF IL1B CARD9 MYD88 PMC4679489__F2 Critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review TBK1 TAB3 MAL TLR9 IRAK1 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR7 UNK PMC2889025__F4 Crosstalk between the PI3K/AKT pathway and p53 activation: Potential stratagies for combined radiosensitization ATR ATM PTEN MDM2 PMC4235299__F1 Genes for which a correlation with Wnt/Beta-catenin signaling was indicated by MetaCore pathway analysis MED12 CNKSR3 APC CCNC PMC4243082__F1 Regulatory network of cell-fate decision upon DNA damage involving (A) the G1/S checkpoint arrest network and (B) the senescence regulatory pathway RB1 ATR CHEK2 CHEK1 ATM MDM2 PMC9516659__F2 Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data FCN2 CENPL CENPM MASP2 FCN3 ODZ1 DFNB31 MPC1 MBL2 CENPH CENPK CENPW LILRB5 SLC1A4 CENPA HPS5 NDP PMC9516659__F3 Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data CENPF FOXM1 RABL6 BUB1B MCM10 E2F4 FOXO1 NEK2 EZH2 MCM2 TOP2A PMC9516659__F4 Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data GSTA3 THRSP CFD SCD LEPR THBD ID1 PMC4905575__F3 PP2A positively and negatively regulates the Wnt signaling pathway APC GSK3B CTNNB1 PMC4905575__F4 PP2A negatively regulates the mTOR signaling pathway ULK1 APC GSK3B MTOR RAC1 IRS1 RHEB MLST8 TSC2 RICTOR TSC1 GRB10 TBC1D7 PMC7665448__F2 SARS-CoV-2 infects the host through angiotensin-converting enzyme (ACE) 2 receptors which are elevated in inflammatory conditions CRP IL33 ACE2 PMC7591896__F1A Transcriptome analysis of chicken intraepithelial lymphocyte natural killer cells infected with very virulent infectious bursal disease virus INHBA OSM RELT BMF NODAL TNF TNLG7C PMC6565995__F2 Gene coexpression network for trans-1,4-polyisoprene biosynthesis involving mevalonate and methylerythritol phosphate pathways in Eucommia ulmoides Oliver HMGCS1 ACAT1 HMGCR ACAT2 MVD FDPS MVK PMC4465592__F1 Attacking the Multi-tiered Proteolytic Pathology of COPD: New Insights from Basic and Translational Studies MMP9 IL8RB PMC3742039__F3 Gene expression in keratinocytes related to IL-1 signaling EGFR LIF PLG PTPN11 IL1A IL6 PMC8807458__F3 Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering SMAD2 SMAD4 PMC3382313__F1 The role of Notch ligands in our models TH STAT1 STAT2 DLL4 TLR9 JAK1 TYK2 MYD88 PMC7346118__F3 Pathways involved in polymyxin-induced nephrotoxicity and the potential nephro-protective mechanism of curcumin FAS NOX4 FADD PMC9534868__F2 Activation of the canonical Wnt signaling pathway RNF43 APC ZNRF3 LRP6 CTNNB1 PMC5777756__F8 Insufficient microwave ablation-induced promotion of distant metastasis is suppressed by Beta-catenin pathway inhibition in breast cancer CDH2 LEF1 CTNNB1 PMC3676786__F1 Representative anti-angiogenic drugs and their targets in the angiogenic pathway FLT3 RAF1 KIT VEGFA PMC3372917__F1 PTPN11-Associated Mutations in the Heart: Has LEOPARD changed its RASpots? TSC2 CBL RAF1 SPRED1 SOS1 NF1 SHOC2 BRAF CS GRB2 MTOR PMC4223355__F9 Model of PLB1 transcriptional activation upon loss of Ypk1 or upon disruption to sphingolipid biosynthesis through treatment with myriocin PLB1 ORM1 PC ORM2 PMC2570214__F8 Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2−/− Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM RHEB EGF TSC2 TSC1 PMC5472757__F9 DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity CGAS IRF3 TREX1 PMC5405080__F9 Functional p53 control of cell growth and oxidative metabolism TIGAR MDM2 MTOR PMC8561620__F5 Regulatory effect between HMGA2 and the Wnt/Beta-catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma HMGA2 LRP5 LRP6 CCND1 CDK4 CTNNB1 PMC9583502__F2 Review on the role of cyclin dependent kinases in cancers STAT3 SMYD2 VASP COX2 MEI1 MMP2 CDK2 HIF1A ARHGAP24 HDAC6 PMC6012981__F5 Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes JAG2 IRF8 PMC5462521__F1 YAP protein interaction, activation, and inactivation within the canonical Hippo Pathway LATS1 NF2 PMC9549360__F4 Regulation and potential roles of m6A modifications in early embryonic development and immune tolerance at the maternal-fetal interface SOCS1 STAT1 DDIT4 TLR4 YTHDF2 NOD1 YTHDF1 METTL3 IGF2BP2 MTOR PMC4123224__F6 Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis TLR1 CXCR4 MYD88 PMC7290655__F6 In PI3K-Akt signaling pathway (KEGG ID: hsa04151), various PKs and PPCPs are involved in translating the extracellular stimuli into phosphorylation signals and propagating these signals into downstream pathways BAD RAF1 SHC1 EGFR GSK3B PIK3R1 SFN IRS1 TSC2 INSR CDKN1B FGFR1 HEL-S-1 GRB2 TBC1D4 HEL2 YWHAZ YWHAG PMC11758792__F1 Lung TME chip operation principles IFNG IL6 PMC5429325__F1 Action of branch‐chained amino acids (BCAAs) POMC MTOR SIRT1 PMC4002662__F2 Chemoprevention of Head and Neck Squamous Cell Carcinoma through Inhibition of NFKB Signaling EGFR RELA TRAF5 TRAF1 TRAF6 TRAF2 PMC4002662__F1 Chemoprevention of Head and Neck Squamous Cell Carcinoma through Inhibition of NFKB Signaling LTB EGFR RELA RELB TRAF5 PTEN TRAF1 TRAF3 MTOR TRAF6 TRAF2 PMC6533679__F12 Schematic representation of the underlying mechanism of miR-137 in CC CDH2 SMAD2 GREM1 PMC8650160__F2 RAD52: Paradigm of Synthetic Lethality and New Developments FANCD2 RAD52 ATAD5 SMARCAL1 RAD51 PCNA HLTF RIF1 SLX4 PMC4939482__F3 Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure ATR MMP2 MMP9 ACE2 PMC8773762__F2 Adipose Triglyceride Lipase in Hepatic Physiology and Pathophysiology EGR1 SP1 SIRT1 PMC4388523__F4 Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells HMBS CPOX ALAS1 ALAS2 FECH UROD HBA2 HBZ UROS HBE1 PMC4939482__F1 Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure ACE2 PMC4977324__F2 Influence diagram of contains partial prior biological knowledge and epigenetic information in the form of methylation and histone modification CD44 DKK4 DACT2 DKK1 DACT3 TCF4 DKK2 MYC CCND1 LEF1 SFRP1 PMC9616080__F2 Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response STAT3 STAT1 TSLP JAK1 PMC9616080__F3 Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response DAZAP2 TRAF4 IL17RB SMURF2 TRAF6 PMC4977324__F4 Influence diagram of is a naive Bayes model that contains minimal prior biological knowledge CD44 DACT1 DKK4 DACT2 SFRP4 DKK1 DACT3 DKK2 MYC CCND1 LEF1 SFRP1 PMC9616080__F4 Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response IL1RL1 IL33 IRAK1 TRAF6 IRAK4 MYD88 PMC8551477__F4 Insulin action at a molecular level – 100 years of progress DDT TG PDE3B CBL GCGR GRB2 INS PMC8551477__F5 Insulin action at a molecular level – 100 years of progress PDX1 INSR FOXO1 PI3 CRTC2 OTOS TCF2 FOXA2 GCK INS PMC2937064__F1 Leptin, IGFBP3, and rapamycin suppress the IGF-1 signaling pathway to preserve naïve T cells and promote longevity STAT3 IGF1 CD27 MTOR PMC7102884__F1 Exhibits the involvement of transduction pathway in AML CXCL12 MTOR CXCR4 PMC2937064__F3 CD28 signaling pathway in T cells is equivalent to the IGF-1 pathway in the whole organism FOXO1 FOXO3A IGF1R PMC8750552__F7 Ginsenoside Rg3 Attenuates TNF-Alpha-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms BAX SIRT3 BCL2 SIRT1 PMC2937064__F4 Reactive oxygen species, UV light or other genotoxic stresses, that induce DNA damage, principally, double-stranded breaks, is detected by the MRE11-RAD50-NBS1 complex, which in turn activates ATM BAX IGF1 ATM MTOR XPC PMC6375051__F2 Mitophagy links oxidative stress conditions and neurodegenerative diseases PINK1 PMC5297661__F6 Protein association networks HSP90AB1 MAPK1 UBE3A IDE UBE2V2 BACE1 UBE2E2 PTEN UBE2D1 MAPK14 TMED10 PSENEN CAMK2A ADAM9 ECE1 PSEN2 HSPA2 HSPA4 UBE2D3 UBE2E1 UBE2A MAPK12 UBB PMC8491233__F2 Mitochondria as a target in cancer treatment FH EGFR PTEN PMC11170970__F6 SH alleviates DSS‐induced colitis via the “SH‐gut microbiota‐5HIAA‐AhR axis AHR IL6 IL1B PMC5584301__F2 SETBP1 dysregulation in congenital disorders and myeloid neoplasms MYB SETBP1 SET PMC7129598__F1 General overview of disease progression FAS ADAM17 GC TNF IL1B PMC3882141__F1 Regulatory Networks and Complex Interactions between the Insulin and Angiotensin II Signalling Systems: Models and Implications for Hypertension and Diabetes RHEB TSC2 TSC1 PTEN PDK2 MTOR PMC6213971__F3 Regulation of PTPIP51 in melanoma FLT3 BRAF LYN PMC8530550__F1 Artificial immune synapse with an introduced DNA-based mechanics-controlling module ZAP70 APC LCK PMC8194072__F1 Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration EGF RHO MTOR CXCR4 PMC7484613__F1 Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6 TET2 IL6 IL1B PMC8194072__F3 Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration IVD MSC CXCR4 PMC2724029__F4 Signaling networks upregulated in migrating neuroblasts HERC1 KCNMB4 CRIPT WASF1 VCAN PMC9255247__F2 Prostate cancer stem-like cells in the development of antiandrogen resistance APC RELA SMO CTNNB1 PMC2724029__F5 Signaling networks upregulated in migrating neuroblasts DIXDC1 TRIO MAP2K4 MAP3K13 VAV2 EPB41L3 ARHGEF7 KALRN ATF2 MCF2L KLHL2 UNK PMC12045949__F1 Molecular Mechanisms Underlying ALKBH5-Mediated Regulation of Hepatic Glucose and Lipid Metabolism EGFR ALKBH5 FASN GCGR MTOR PMC8427323__F1 Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells MAL CYC1 IMPACT PMC9019265__F1 Statins and endocrine resistance in breast cancer RAB27B RHO MTOR PMC6854496__F1 RIG-I-like receptor (RLR) activation by various RNAs during DNA virus infection TBK1 MAVS IRF3 IRF7 DUSP11 MRPL18 PMC5511499__F4 How is the Brain Renin-Angiotensin System Regulated? LRP5 CTNNB1 PMC8387362__F1 Study workflow BRDT ERCC2 NCOR1 BRCA1 BRCA2 ATM PTEN PALB2 PMC3613369__F3 Intra-Tumoral Heterogeneity in Metastatic Potential and Survival Signaling between Iso-Clonal HCT116 and HCT116b Human Colon Carcinoma Cell Lines PTGER2 HEL113 CD36 TNFSF6 EPB41L3 NTRK2 MAFB EFS FGF8 BEX4 FGF8A CPA4 COLEC12 CCND2 DKK1 Nbla10317 RGS4 AKAP12 AQP1 PMC9110257__F9 LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells MFN2 CASP3 LARS2 PMC1592599__F1 TNFA signaling pathway leading to apoptosis or proliferation of the cells TRADD TNF TRAF2 FADD PMC4394389__F8 Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom MAL CSK ARHA PMC9247951__F2 Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance PROX1 GATA2 HGF PAX8 NRP2 DLX2 SRC WIF1 SPP1 PMC6952997__F8 Influence of ethylene on amount of compounds and expression of genes in lipid pathway in peach LPA PGP PSD PEMT PC CP PMC5746035__F3 Oncogenic regulation of glucose flux into PPP CDK6 F2 TIGAR PMC7564365__F6 Pilot Study on MicroRNA Profile in Tear Fluid to Predict Response to Anti-VEGF Treatments for Diabetic Macular Edema ENG SMAD1 BAD RAI1 COX2 SMAD2 PMC5746035__F1 The glycolysis and pentose phosphate pathways (PPP) are tightly connected F2 FBP1 HEL-S-5 TIGAR PMC6152083__F10 Part of the PPAR signal pathway LPL EHHADH OLR1 AQP7 CD36 PMC4709516__F3 The Dendrobium catenatum Lindl. genome sequence provides insights into polysaccharide synthase, floral development and adaptive evolution GAL FRK PMC8982327__F5 Targeting transforming growth factor‐B signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin SMAD2 SMAD4 PTEN PMC5818366__F1 “cross-talk” between liver and peripheral organs in the pathogenesis of NAFLD PNPLA3 POMC NPY AgRP PMC8982327__F1 Targeting transforming growth factor‐B signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin SMAD2 SMAD4 MTOR PMC5998384__F3 Metabolic PathwaysCell-cycle effect on the stability of protein components of the pentose phosphate pathway (PPP) HEL107 HEL-S-5 PMC11740669__F1 Autophagy negatively regulates pyroptosis pathway MARCHF7 PTPN22 GSDMD RALB NLRP3 ULK1 USP18 IRGM MIB2 PTEN LGALS9 MTOR PMC9247951__F3 Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance STAT3 NRCAM VEGFC CANX EGFR NRP1 CHL1 PLXNB1 SEMA3E CTNNB1 TGFBR2 NR3A2 SRC CREB1 MAPK1 ITGA7 SEMA3G NRP2 SNCA PLXND1 VEGFA ESRRA SEMA3C COX16 NXPH2 ITGB1 ARL6IP5 NR2F2 PLXNA1 PLXNA3 PCDHGB1 CASP3 ESYT1 BCL2 SEMA3B PMC3823093__F4 Network analysis of proteomics using IPA SRP19 OXCT1 UQCR10 ADAMTS9 H1-1 MYC NDUFS3 SUSD2 PROX2 MFHAS1 KRT9 ERBB2 DLD MYH8 TNNI3 ZNF71 MYH13 PMC6068015__F1 Lymphoma immune evasion mechanisms CD80 CD58 CD2 FAS HLA-G SIRPA CCR4 CD47 LAG3 PMC3520045__F4 Summary diagram of Nrf2 and HIF1 stimulation in presence of oxidative stress KEAP1 EPO VHL HEL-S-44 PMC11740669__F6 LMP with STAT3 signaling pathway promotes pyroptosis and ferroptosis STAT3 CGAS GSDMD NLRP3 HEL-S-130P DFNA5 PMC6731416__F9 Proposed model for the roles of Wnt/Beta-catenin signaling regulated by quercetin in protection of BBB breakdown GSK3B LEF1 CTNNB1 PMC11740669__F2 Ferritinophagy regulatory network influences ferroptosis sensitivity HERC2 FBXL5 FTH1 FTL KEAP1 MTF1 TFEB ATM MTOR VAMP8 PMC11740669__F3 Mitophagy resists two forms of cell death BAX GSDMD PINK1 NLRP3 GPX4 ULK1 TFEB BNIP3 DFNA5 FUNDC1 MTOR PMC11740669__F5 Innate immune system regulates two types of ICD through autophagy LATS1 TBK1 CGAS GSDMD NLRP3 GPX4 TLR4 POLG MYD88 PMC6326181__F7 Integrative Modeling of Cancer-Type-Specific Hippo Regulatory Networks ARID1A EGFR MCL1 STK4 SMAD4 PTEN IGF1R TEAD4 LATS1 RB1 MOB1A FRMD6 MOBKL1A CDKN2A LATS2 TEAD2 TEAD3 ZNF217 ATM NF2 HEL-S-26 TAOK1 TAOK2 CIC APC SOX2 KRAS YAP1 RNF43 WWC1 TAOK3 ERBB2 IKZF2 PMC3823158__F1 Canonical NFKB signalling pathway TRADD BCL10 TRAF2 PMC5209488__F6 Summary of the mechanism of Dicer regulation in osteogenesis APC PTEN RUNX2 CTNNB1 PMC2493210__F1 Schematic diagrams of small intestine mucosa in normal and infected intestines BPI TLR4 NOD2 PMC7848146__F2 Signaling pathway and mechanism related to lung cancer driver gene in brain metastasis PTEN MTOR CTNNB1 PMC1797319__F1 Shewanella oneidensis MR-1 anaerobic carbon metabolism pathway MAL CIT PMC6770221__F6 Mechanism of optimal therapeutic drugs in each subtype of breast cancer JUN RAF1 ABO BRAF KDR PMC5381176__F8 MiR-93 activates the PI3K/Akt pathway by targeting LKB1/PTEN/p21 TSC2 TSC1 EGFR PTEN MTOR PMC3394417__F1 Sample gene regulatory network RALBP1 PMC5203625__F3 Selected metabolic pathways of the putative novel SAOB unFirm02_FrBGR cluster 2 C2 HEL-S-5 FES PMC7369933__F3 One-carbon metabolism, DNA/histone methylation, and drug interaction VIT MTHFD1 PMC7493015__F7 Epithelial repair mediated by LXA4 in bronchial epithelium PANX1 P2RY11 FPR2 PMC7493015__F3 Arachidonic acid (AA) metabolome and abnormal class switching in CF COX1 COX2 C2 PMC8849533__F8 Working model of the role of CNTN1 in the regulation of MAVS-mediated signaling and influenza A virus replication USP25 TBK1 MAVS CNTN1 IRF3 PMC7493015__F5 Ion transport regulation by LXA4 and RvD1 enabling the restoration of ASL height in CF human bronchial epithelial cells PANX1 ASL P2RY11 FPR2 PMC6102449__F6 Working pathway for Er-Miao-Fang inhibiting inflammation and blocking hepatic gluconeogenesis PDE3B PDE4B IL1B PMC2899872__F1 Sequence Comparison Suggests a Role for TTL in Allantoin Biosynthesis.(A) Alignment of TTL with Urad and Urah protein from zebrafish TTL URAD PMC9367608__F1 Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma GOT2 HEL-S-133P HK2 FASN PMC3182268__F1 Apoptotic pathway to cell death from the perspective of the Bcl-2 family of proteins.1, The intrinsic pathway is initiated by various signals, principally extracellular stimuli BAX BAD FAS PMC8830542__F1 Nevi, dysplastic nevi, and melanoma: Molecular and immune mechanisms involving the progression MC1R POMC BRAF PTEN PMC5562214__F7 Cardioprotective effects of macitentan MLYCD SERPIND1 PPP1R3A SERPINC1 SGCB APPL1 CD36 SIRT2 COX6A2 CTNNB1 STAT1 PTGIS HEL-S-130P PON1 XDH LARS2 TRIM72 CSPG4 WFS1 PMC6391848__F4 Enrichment analysis of differentially expressed mRNAs RB1 PROC PMC8492658__F1 Cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients PLCB4 PTGER2 COX1 PTGIS COX2 HEL-S-2a XDH PMC8492658__F6 Cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients AGTR1 APLN ACE2 PMC9147606__F2 Endothelial Dysfunction Induced by Extracellular Neutrophil Traps Plays Important Role in the Occurrence and Treatment of Extracellular Neutrophil Traps-Related Disease TF NLRP3 TLR4 TLR9 TLR7 REL IL1B MPO PMC4716080__F1 Wnt-Beta-catenin signaling pathway CD44 APC LRP5 LRP6 CTNNB1 PMC3789714__F1 Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens TSC2 TSC1 ULK1 MTOR PMC5477782__F8 The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation HMGB1 HP CD163 PMC6084451__F1 Host-Intrinsic Interferon Status in Infection and Immunity STAT1 MAVS STAT2 IRF9 IRF3 PMC5825896__F9 Schema of the anti-HIV mechanism of toll-like receptor 3 (TLR3) signaling of intestinal epithelial cells (IECs) TLR3 CCR5 IRF3 IRF7 ISG15 MIP PMC9147606__F3 Endothelial Dysfunction Induced by Extracellular Neutrophil Traps Plays Important Role in the Occurrence and Treatment of Extracellular Neutrophil Traps-Related Disease TF CTNNB1 MPO PMC2648516__F1 SKN-1 and the Wnt effector TCF/POP-1 reveals differences in endomesoderm specification MED12 SYS1 MED1 POP1 PMC4052347__F5 PPI network and signaling pathway analysis PPARG JUN BOP1 NFATC1 MAPK9 MAPK8 FOS MAPK3 HDAC3 MAPK14 RBBP7 GSTM1 HDAC10 HDAC8 CASP3 CREBBP HDAC7 NFKBIB PMC6056651__F7 Pan-Cancer Analysis Reveals the Functional Importance of Protein Lysine Modification in Cancer Development PHF20 LDB2 PBX1 IL33 MMAA MMACHC PAX5 PAX2 ATF7 IGF2BP2 MTHFS USP21 SMUG1 ANO10 SPTBN2 DAB2IP ANGPT2 COG3 SYMPK EIF4E3 CYP2C9 TCN1 MTR ARID4A ARID4B GOLGA2 ADPRHL1 ACYP1 NOL11 ATXN10 CAMKMT HOXB1 INO80C PAXIP1 KLHDC10 KLHL29 PHF12 IBTK LAS1L FXYD2 INTS11 AOC2 ASH2L ZNF644 CDCP1 RBM34 MGA PLEKHG4 CTCF MSL3 SLC47A2 ARHGEF11 WIZ CDKAL1 WDR18 ETNPPL BACC1 PABPC1L MTHFD2L SSU72 CUBN PAIP1 GLYCTK EIF2AK1 ZBTB7B SLC22A2 ACSM5 ACSS3 ACOT12 RUNX1 MAFF ALDH7A1 DDIT3 HEL162 DDX3X CARNS1 CR2 MTRR SLC30A8 SETD2 EYA1 AMN SIN3B PABPC4 SUPT6H ADHFE1 RILP EIF2AK4 PKNOX1 E2F6 OSBPL1A PABPC5 EIF2AK2 DCSTAMP ATF5 FOSB RBBP6 WDR33 PAPOLG RUNX3 CFDP1 KDM2A COG6 COG5 SPTB NRCAM GOLGB1 CYP4A22 CHD8 SMOX SQSTM1 RUNX2 TNFRSF8 KMT2A PCDH8 FOXN2 MLL2 PAN3 ATF4 KMT2C DHX30 EIF4B JDP2 SMAD6 NFATC1 HAND2 GATA3 NFE2L2 PMC11583782__F1 Predicted pathway and gene network in the treatment of AD with Jiawei Qifuyin PPARG GSK3B CHRM3 PPP3CA RXRG MAOA IFNG PSMD3 CHRM4 DRD1 ALOX5 CASP9 NOS2 GSTM1 GABRA2 CHRM2 RXRA ADRB2 BCL2 ADRB1 GRIA2 TGFB1 CHRM1 ADRA1A HTR2A CHRNA2 SLC6A3 MAP2K4 F2 CACNA1S IL1B HSP90AB1 CYP1A2 ACHE BAX CHRM5 JUN SELE CHRNA7 GABRB3 OPRM1 PTGS2 CYP1A1 ADRA2C RELA CASP3 NFKBIA PRSS1 CYP3A4 PMC7914934__F2 Proteomics Complementation of the Rat Uterotrophic Assay for Estrogenic Endocrine Disruptors: A Roadmap of Advancing High Resolution Mass Spectrometry-Based Shotgun Survey to Targeted Biomarker Quantifications HEL-S-134P SRI PPP5C F7 BLK GM2A HSPB2-C11orf52 WEE1 FARSB CDCA7 ABCC9 CNBP ABLIM1 PMC6524659__F2 Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets ADAR BAD TRADD MAVS RBCK1 RELB IFIT3 PML IFIT2 MTOR TRIM21 NLRP3 SP100 TLR7 EIF2A ISG15 BAX CASP9 NOS2 IFI6 STAT2 IRF9 RNASEL IRF1 IRF3 IRF7 RSAD2 TNF CXCL10 RAC1 CXCL11 TSC2 TSC1 TRIM25 TLR3 CASP3 IFI27 JAK1 TNFSF10 TRAF2 TYK2 PMC3048558__F7 Proposed mechanism of gene regulation in response to extracellular and intracellular dsRNA stimulation TLR3 RELA RELB PMC9005749__F2 CD155/TIGIT in Digestive Cancers: Promising Cancer Target for Immunotherapy CD226 TIGIT GRB2 PMC5771804__F4 GD T cells in homeostasis and host defence of epithelial barrier tissues CXCL9 MYD88 PMC11574213__F3 New insights into crosstalk between Nrf2 pathway and ferroptosis in lung disease STAT3 KEAP1 GPX4 NQO1 MAF TERT SLC7A11 TNF PMC1350949__F7 Proposed model of the HCMV-induced apoptotic signaling pathways BAX CASP9 ATR CASP3 ATM PMC7774741__F1 Flow chart for selecting SNPs in retinol metabolism pathway genes ALDH1A3 HEL-S-53e MAF PMC8037152__F1 Leukemic microenvironment supports survival of acute lymphoblastic leukemia (ALL) cells and their immune evasion through multiple interactions CXCL12 MSC CD200 CXCR4 CD47 PMC8043392__F11 Coordinated changes in the expression of Wnt pathway genes following human and rat peripheral nerve injury APC RYK AXIN2 CTNNB1 PMC5738696__F1 IGF1R signaling pathway and its relevant drug resistance mechanisms: Promoting proliferation, inhibiting apoptosis and inducing changes to ABC transporter proteins and the ECM BAX WT1 SP1 IGF1 IGFBP7 IGF1R MDM2 GRB2 IGF2 IRS1 PMC2639705__F9 Two Chromogranin A-Derived Peptides Induce Calcium Entry in Human Neutrophils by Calmodulin-Regulated Calcium Independent Phospholipase A2 CGA GC PMC7754042__F7 miR‐218 could inhibit OSCC proliferation, migration, invasion, EMT and liver metastasis through the TGF‐B signalling pathway by regulating GREM1 GREM1 SMAD4 PMC8353397__F10 Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis ZAP70 HDAC1 NGF LTA TRADD HDAC2 PMC9093074__F2 Dual-Targeted Therapy Circumvents Non-Genetic Drug Resistance to Targeted Therapy CDC2 ATR WEE1 ATM SRC PMC6989439__F2 Cellular-mediated rejection SLA APC SIRPA CD47 PMC6989439__F3 Coagulation cascade related to xenotransplantation TF VWF TFPI APC PC PMC8945550__F1 Cutting-Edge Therapies and Novel Strategies for Acute Intermittent Porphyria: Step-by-Step towards the Solution HMBS AIP PMC6888641__F1 PI3K/mTOR signaling cascade CDC2 JUN BAD ULK1 PTEN MYC RHEB TSC2 TSC1 CCND2 BCL2 DEPDC5 MDM2 PMC11174581__F1 Promotion mechanisms of microecologics on sports performance WNT10B CORT TGFA UCP1 SIRT1 PMC8853618__F14 SPOCK1 Promotes the Development of Hepatocellular Carcinoma EGFR SPOCK1 SRC CDK4 PMC3005023__F1 Hypoxia and hypoxia-inducible factors (HIFs): master regulators of metastasis TGFA IGFBP1 EPO LOX ANGPT1 ZEB2 NOTCH1 NOS2 ADM HEL-S-133P FGF5C VEGFA IL6 HEL-S-30 IGF2 VHL RBX1 TCF3 ANGPTL4 HEL-S-130P HEL-S-68p HEL-S-162eP PFKL CXCR4 TWIST1 PMC1876599__F3 Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR STAT3 PELP1 BCAS2 SUMO2 RAF1 FHL2 GRB2 HDAC2 GPT PMC8126563__F3 Protein kinase CK2: a potential therapeutic target for diverse human diseases KNS2 SKP1 SET PMC3714263__F6 ERK Positive Feedback Regulates a Widespread Network of Tyrosine Phosphorylation Sites across Canonical T Cell Signaling and Actin Cytoskeletal Proteins in Jurkat T Cells PLCG1 FYN NCK1 ME2 LAT CD33 ITK VAV1 ME1 GRB2 LCK PMC8126563__F1 Protein kinase CK2: a potential therapeutic target for diverse human diseases STAT3 MRE11A PTEN MDC1 CTNNB1 PMC8126563__F2 Protein kinase CK2: a potential therapeutic target for diverse human diseases PML ARC CDC37 MDM2 EIF2A ABCG2 PMC8091781__F10 COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/Beta-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells BIRC5 APC GSK3B CCND1 NEDD9 CTNNB1 PMC3708893__F5 Oral Neutrophil Transcriptome Changes Result in a Pro-Survival Phenotype in Periodontal Diseases HTRA2 TBK1 FAS TRADD SKI TRAF2 DIABLO FADD PMC7183876__F2 MiR-21 and miR-17~92 promote cyst growth NR1C1 PKD1 MTOR PMC4510836__F1 Complement cascade and its regulators C6 CD59 FH C7 HEL-S-62p C2 C9 CD46 CR1 PMC4510836__F2 Complement activation on allograft injury IFNG CD80 CAD APC CR2 PMC8935220__SF1 Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2 KEAP1 NQO1 MAF PMC12121617__F7 BNC1 acts on the CCL20 promoter to suppress the expression of CCL20 in GC cells BNC1 STAT3 BAX CCR6 CCL20 PMC7590238__F1 ICL repair pathway at different cell cycle phases FANCD2 XPA REV1 FAN1 SLX4 EME1 XPC PMC6417502__F8 Collagen upregulates MMP-14 through activation of the TGFB/TBRI/Smad3/Snail pathway EGR1 SRC CTNNB1 PMC7461207__F3 Mechanotransduction signalling for osteogenesis of human mesenchymal stem cells (hMSCs) SMAD1 BMP2 RUNX2 FOS PMC10816924__F7 KLF10 in cardiac fibrosis HDAC1 BAX PTTG1 BCL2 KLF10 IL9 PMC3883721__F1 Phosphoinositide-3 kinase (PI3K) is a heterodimer consisting of p85 and p110 subunits TSC2 TSC1 MTOR PMC4359534__F7 Cardiovascular disease, lipid metabolism, molecular transport EMP1 EDN3 BMP3 DBI LIPG INSIG1 PMC7542480__F4 Protein-protein interaction network GSTM1 PARG CYP2C19 PDPK1 RXRA PRDX5 HSD11B1 NR1C2 XDH TNF PLA2G2A PMC4359534__F8 Cell-cell signaling and interaction, molecular transport, small molecular biochemistry NTS UCP3 AOAH LMX1A ADRB1 NEDD9 PMC6332742__F1 The central role of C1 inhibitor in various plasma systems., Upon contact with negatively charged surfaces factor XII (FXII) is (auto‐) activated to activated factor XIIa (FXIIa) PRCP C1S C1R PLG PMC2728144__F6 Schematic diagram depicting our findings on the post-transcriptional regulation of CXCR4 in MCF7-HER2 cells as a result of estrogen and HER2 cross-talk and the involvement of activated PI3K and MAPK pathways and TSC2 (tuberin) TSC2 PI3 MTOR CXCR4 EIF4E PMC8894804__F1 ULK1 Signaling in the Liver: Autophagy Dependent and Independent Actions NCOR1 KEAP1 RPS6KB1 FUNDC1 PMC5362561__F1 Scheme of the metabolic pathway of purines and their relation to hypoxanthine-guanine-phosphoribosyltransferase (HPRT) PNP ADSL ADA PMC8885406__F3 XPO1 mediated emergent drug resistance pathways TOP2A SET CTNNB1 PMC4991833__F4 Simplified model for the symbiotic signaling pathway in legumes NUP133 NUP85 PMC4391565__F10 H3K56 acetylation prevents genomic instability by affecting Ctf4 function MCM7 MCM3 MCM5 MCM6 MCM2 POLE PMC7787056__F4 Duality of human oncoproteins: drivers of cancer and congenital disorders ALK EGFR KIT RET PMC7108731__F1 Influence of rare variants in circulating metabolic biomarkers PDP2 PDPR PDK2 PMC6302517__F3 Schematic illustrating the role of cav-1 in different cell TLR4 MYD88 PMC7326806__F5 Reciprocal regulation between brain cancer and neuronal cells in the brain SMAD4 APP ADAM10 HEL-S-11 NLGN3 PMC4694672__F7 Silk + bLf NPs induced apoptosis in EGFR +ve and EGFR −ve cells.Notes: Internalization of both forms of nanoformulation was facilitated via LRP1 receptors and EGFR in MDA-MB-231 cells and via death receptors in MCF-7 cells BAX NPS FAS EGFR PMC7326806__F3 Overlapping molecules in cancer and neurodegenerative diseases BAX NQO1 GSK3B CDK2 APP PIN1 CCND1 PMC8032583__F1 Serum 4Beta-hydroxycholesterol increases during fluconazole treatment CYP51A1 SQLE DHCR24 PMC4664252__F9 Distinct Upstream Role of Type I IFN Signaling in Hematopoietic Stem Cell-Derived and Epithelial Resident Cells for Concerted Recruitment of Ly-6Chi Monocytes and NK Cells via CCL2-CCL3 Cascade CCL3 IFI16 CCL4 CCL5 CCL2 PMC7145987__F4 DNA damage response defects in high risk neuroblastoma (HR-NB) MAX ATR MRE11A H2AX AURKB CHEK1 ATM BLM PMC8360618__F3 MUC1 is an oncoprotein with a significant role in apoptosis (Review) BAX FAS MEI1 MUC1 FADD PMC4600855__F1 S-nitrosylation in TRAIL/DR4 and FaL/Fas signaling pathways CASP9 FAS CASP8 CASP3 YY1 FADD PMC7593679__F1 TRP and its key catabolites (TRYCATs) produced via three biochemical pathways: the kynurenine pathway, tryptamine pathway, and serotonin pathway TPH1 TDO2 IDO1 KMO IDO2 PMC4600855__F2 S-nitrosylation in classical TNF-NF-kB signaling SHARPIN CASP8 TRADD TRAF2 FADD PMC2435380__F1 Methionine metabolic pathway HEL-S-182mP HEL-S-61p PMC4600855__F3 S-nitrosylation in TNF-JNK-AP-1 signaling TRADD TRAF2 FOS PMC8526538__F8 Lysosomal-Associated Protein Transmembrane 5 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy LAPTM5 PRAC1 RAC1 PMC5995375__F8 Endothelial cell activation is attenuated by everolimus via transcriptional and post-transcriptional regulatory mechanisms after drug-eluting coronary stenting SELE VCAM1 TNF PMC11039397__F7 Mechanism diagram of SR1 alleviating bone lossIn the natural environment, air pollutants contain different AhR ligands DCSTAMP CTSK AIP ATP6V0D2 AHR AHRR NFATC1 TRAF6 ACP5 PMC8555053__F4 On the role of dauer in the adaptation of nematodes to a parasitic lifestyle NCR1 IGF1 SGK1 PPM2C PMC7400736__F3 Interaction network of the let-7 family targeting the IGF family members generated from HMDD version 3 TES ARID1A FXN AP1S1 IGF1R ACTA1 MPL MDM4 CCNG1 BCL2L1 BTG1 F2R MDM2 CCND1 MYBPC3 IKZF3 ARG2 CRX IL13 EPHA4 KRAS IGF2 IGF1 CDKN1A EDN1 CASP3 EN1 BCL2 PMC11923913__F7 Cellular mechanisms, signaling pathways, and potential therapeutic targets in TRALI CD40 HMGB1 CXCR4 ROBO4 PMC7400736__F4 Crosstalk between the insulin/IGF signalling pathways and the potential targeting of let-7 RLN2 RLN3 INS-IGF2 IGFBP1 IGFBP4 IGFBP2 INS IGF2 IGFBP6 PAPPA2 IGF1 IGFBP5 INSR INSL6 RLN1 INSL5 PMC7150862__F8 Schematic model of miR-202-5p-mediated RIG-I-like receptors (RLRs) signaling pathway during viral infection TBK1 MAVS TRIM25 IRF3 TRAF3 TRAF6 PMC514698__F1 Known Yeast Cell Cycle Interactions CDC20 CDC6 CLN3 PMC4286601__F1 Main glucose degradation pathways in the heart HEL107 HEL-S-162eP PMC6193168__F5 Involvement of mitophagy in the transportation of amorphous calcium phosphate (ACP) precursors from the mitochondria to the extracellular matrix in stem cells with osteogenic potential LAMP2 SMAD1 PINK1 SMURF1 DKFZp781O1323 BMP2 SMAD4 RUNX2 PMC5045388__F4 Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer ARAF EDN1 MTOR PMC7993678__F6 Cancer associated fibroblasts (CAFs) from osimertinib-resistant patients promoted osimertinib resistance via HGF/MET signaling and induction of epithelial-to-mesenchymal transition (EMT) and transformed NSCLC cells into TKI resistant stem-like cells HGF EGFR CTNNB1 PMC5852508__F6 Proposed central and peripheral pathways/mechanisms being activated by circulating Ang II and high dietary salt intake NTS AVP PMC11923913__F5 Signaling pathways in TRALI CD40 CXCL12 HMGB1 SLIT2 TLR4 MTOR CXCR4 ROBO4 PMC3322580__F4 Enrichment and submodularization of cell cycle in terms of E3-mediated regulatory modules RAD21 DCX CDC20 PCNA CD14 SNCA MDM2 SCT PMC11923913__F6 TRALI‐targeting therapies CD40 HMGB1 MR1 TLR4 MTOR CXCR4 PMC2974215__F2 TNF-dependent signalling pathways mediated through TNFR1 and TNFR2 TRADD TNF TRAF2 FADD PMC10518396__F7 Overcoming the therapeutic limitations of EZH2 inhibitors in Burkitt’s lymphoma: a comprehensive study on the combined effects of MS1943 and Ibrutinib BTK BCR EZH2 PMC4086337__F1 NLRP3 inflammasome regulates the caspase-1 dependent maturation and secretion of pro-inflammatory cytokines NLRP3 TLR4 IL1B PMC3377094__F2 Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins TBK1 TIRAP TAB3 TLR9 IRF3 IRF7 IRF8 TRAF6 TRIM21 MYD88 TLR3 TLR4 RELA TLR7 TRIM23 PMC11673339__F5 Search for pathways that reflect gene expression effects of Semax and ACTH(6–9)PGP at 24 h after tMCAO in FC NAGS EGR1 P4HA2 JUNB EGFR SPHK1 EGR2 TNF FOS PMC3170448__F5 Simply comparing and contrasting the expression patterns of perturbed genes was inadequate for deciphering the MAPK pathway response dynamics TRO FGF7 MAP2 DUSP14 YWHAZ PMC6287148__F1 Mitogen-activated protein kinase pathway EGFR BRAF GRB2 KRAS PMC6036835__F5 KEGG pathway (FDR < 0.05) enriched by the 289 differentially expressed genes in drug group compared to model group RPS15A CACNG7 ATP6V1C1 COX7A2 RPL34 MRPL2 MRPL27 RPL37 COX6B2 COXFA4 PMC4461477__F5 Emerging molecular machinery and therapeutic targets of metastasis MMP2 VCAM1 PMC1958996__F2 Transcriptional control of adipocyte formation E2F4 CDK4 PMC11889691__S1 Multiscale mechanical-adapted hydrogel for the repair of IVDD IVD COX2 MMP3 MMP9 PMC8220440__F2 Multifunctional inhibitors of SARS-CoV-2 by MM/PBSA, essential dynamics, and molecular dynamic investigations TRADD EBP LIF TNF IL1B PMC11677934__F8 Essential Role of Cortactin in Myogenic Differentiation: Regulating Actin Dynamics and Myocardin-Related Transcription Factor A-Serum Response Factor (MRTFA-SRF) Signaling YAP1 PMC8220440__F3 Multifunctional inhibitors of SARS-CoV-2 by MM/PBSA, essential dynamics, and molecular dynamic investigations TRAF1 TRAF3 TNF TRAF2 PMC9661523__F4 Non-cardiomyocytes in the heart in embryo development, health, and disease, a single-cell perspective CA4 PDPN EFNB2 SMOC1 RGCC SEMA3G CD36 TBX1 DLL4 NTRK2 NFATC1 FABP4 IL6 RSPO3 CCL2 PROX1 FBLN5 CDH11 CX3CL1 FY NPRC PMC6527283__F2 Interaction of tumor-associated macrophages and cancer chemotherapy STAT3 CD80 PMC2213208__F1 Activation of the vagus nerve leads to the release of acetylcholine (Ach) that binds to Alpha-7 nicotinic receptors (A7 nAChR) on cytokine producing cells STAT3 HMGB1 SOCS3 TNF PMC9493050__F7 Calcium dobesilate efficiency in the treatment of diabetic kidney disease through suppressing MAPK and chemokine signaling pathways based on clinical evaluation and network pharmacology HRAS JUN RAF1 TRADD AKT3 CASP3 CCL5 GRB2 SRC TRAF2 PMC2860555__F1 Endosomal and cytoplasmic pathways for virus recognition and IFN production TBK1 MAVS TLR3 TLR8 IRAK1 IRF3 IRF7 TLR7 TRAF6 IRAK4 MYD88 PMC9693603__F11 Inhibition of NF-kB/IL-6/JAK2/STAT3 Pathway and Epithelial-Mesenchymal Transition in Breast Cancer Cells by Azilsartan STAT3 BAX BCL2 MMP9 PMC8668986__F10 Metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer STAT3 TYK2 PMC5496137__F1 Central metabolic pathways of E HBD CIT PMC4726471__F2 Interplay Between Centrosomes and the Hippo Tumor Suppressor Pathway LATS1 LATS2 MDM2 PMC5700047__F8 Proposed model of CHK1 as a facilitator of transformation and drug target BAX BCL2 MYC PMC11019653__F7 Effect of 23‑hydroxybetulinic acid on lung adenocarcinoma and its mechanism of action MDM2 PTGS2 PMC11354767__F6 GPR30 signaling pathway STAT3 HBEGF EGFR GRB2 SRC PMC3466049__F1 Complement-targeted therapeutics in periodontitis IFNG TLR1 TLR4 GSK3B CD14 IRF1 CXCR4 RAC1 PMC4359534__F9 Lipid metabolism, molecular transport, small molecule biochemistry AMN HTR2B MYL1 FOSB CRHR2 GATA6 CALCA CUBN DKFZp761E1322 CRHR1 PMC2761008__F2 Minimum spanning tree of the network associated with cancer pathway genes RGS2 NRCAM SKIL PCNA CTSH SMAD2 RGS16 MGLL MEF2C TGFBR1 KPNA2 MYLK PIG59 ID4 ATM MAPRE2 APP TBP DGKZ GHR MST065 SOX4 RPL31 NGFR SNCA RBL2 CCNI PICALM DDB2 CCNE2 HBEGF MT2A MAFF HEL-S-130P UBE2B RELA RUVBL2 PRKAB2 CDK2 BCL2 RPS6KA3 GRB2 ACTG2 PMC2761008__F3 Cliques or near cliques from the cancer pathway related network Gp BGLAP HEL-S-2 SKIL THBS1 TGFB1 RPL31 ID2 SMAD2 RBL2 RUNX2 CSTB FOS RPL35A MYLK BCL2L1 HEL-S-130P ID4 MCM3 CDK2 ATM GRB2 DDX56 ACTG2 PMC6422174__F1 Linking Signaling and Selection in the Germinal Center IL-21 CD40 FH FOXO1 PMC11200706__F2 Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes DCT TYRP1 CTNNB1 PMC3101816__F1 The central role of cIAP1 in NFKB signalling and programmed cell death CAP2 TRADD TRAF2 FADD PMC7133220__F9 Putative mechanisms by which neratinib down-regulates mutant K-RAS expression and inactivates Hippo Pathway function LATS1 LATS2 ATG16L1 ATM PMC5348443__F2 Kinase inhibitors as potential agents in the treatment of multiple myeloma CD40 RELA RELB PMC6386826__F1 Signaling transduction of mTOR pathway MLST8 CDKN2A TSC2 RICTOR TSC1 SGK1 PTEN MDM2 MTOR EIF4E PMC10476361__F6 HDAC5 regulates MEF2A expression by influencing the ERK/EGR1 signaling pathwayVentricular remodeling induces cytoplasm translocation of HDAC5 EGR1 HDAC5 PMC4437987__F1 Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors RPS6 MLST8 EGFR PMC5488651__F3 Bacterium Helicobacter pylori is a well-studied example of a pathogen manipulating host PAK1 signalling PAK1 TLR4 RAC1 IL1B PMC8476122__F2 Pembro enhances Gln uptake/release of glutaminolytic products while blocking Gln-fueled Krebs cycle activity in primary CA but not in NC lung tissues GLS HEL-S-62p C2 PMC3442865__F1 TOR pathway activation MTOR EIF4E PMC4336822__F1 Progesterone action in breast, uterine, and ovarian cancers HBD CDK2 PMC8058565__F5 Sulfation of 25HC as an epigenetic regulatory pathway CAV3 CAV2 BAD HMGCR CREB1 SIRT1 PMC8917703__F2 Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation P2RX7 CXCR3 TBK1 CGAS APC EZH2 CXCL10 HEL-S-99n P2RY2 TLR4 RELA IFNAR1 VCAM1 CMTM4 PMC4355395__F4 The 12/15Lipoxygenase as an emerging therapeutic target for Alzheimer's disease CDK5 SP1 APP PMC4336822__F3 Progesterone action in breast, uterine, and ovarian cancers IGF1 DKK1 IHH HAND2 PMC6851227__F1 Metabolic alterations in AML blasts GLS HEL-S-133P HK2 CS MTOR HEL-S-26 PMC6503643__F2 HSVs modulate antiviral mechanisms related to cell death in non-immune cells BAX LAT EIF2A PMC6851227__F2 Enhanced tryptophan-turnover in AML blasts IDO1 KMO AHR MTOR PMC6503643__F4 HSV proteins modulate key steps in interferon-related pathways STAT1 STAT2 CREBBP IRF3 IRF7 TRAF3 JAK1 PMC6503643__F5 HSVs interfere with antiviral processes in innate immune cells PIGT TBK1 TLR1 CGAS MICA CD1D PMC9605425__F5 Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NFKB Pathway RELA VCAM1 CCL2 TNF PMC5482757__F4 Emerging Role of MicroRNAs in mTOR Signaling RHEB TSC2 TSC1 PTEN MDM2 DROSHA PMC4259450__F2 Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences CDC2 TSC2 CDK6 TSC1 EGFR CDK2 PTEN MDM2 MTOR MYC CDK4 PMC2695826__F2 Age-Related Decrease in Proteasome Expression Contributes to Defective NFKB Activation during Hepatic Ischemia/Reperfusion GUSB RAN PMC3772092__F7 Cadherin 6 Is a New RUNX2 Target in TGFB Signalling Pathway TF TNC SNAI2 HEL113 SNAI1 CDH6 RUNX2 ID1 CDH16 PMC5482757__F1 Emerging Role of MicroRNAs in mTOR Signaling RHEB TSC2 RICTOR TSC1 PTEN MTOR PMC7718880__F8 Schematic diagram illustrates the mechanism for the effect of the oxalate/LCN2/ERK and p-ERK and the expressions of LCN2, PTGS1, GPX3 and MMD axises on renal epithelial cell damage during kidney stone formation PTGS1 GPX3 LCN2 MMD PMC5482757__F2 Emerging Role of MicroRNAs in mTOR Signaling RHEB TSC2 TSC1 DDIT4 PTEN BDNF PMC2695826__F1 Ingenuity pathway analysis identified a network of genes down regulated in response to 60 minutes of ischemia in aged mouse liver FUBP1 ATF2 CCNH PMC4037130__F1 Targeting protein prenylation for cancer therapy CDC42 RHEB TSC2 BAD TSC1 TIAM1 RIN1 RHO MDM2 RAC1 PMC5482757__F3 Emerging Role of MicroRNAs in mTOR Signaling RHEB TSC2 TSC1 CAB39 DDIT4 PTEN BDNF PMC10870461__F16 Signal pathways related to CALD1 mapped by KEGG database CAD ADM EDNRA CNP ARHA PTGIR AVP PMC6676344__F2 Graphical summary of the anticancer mechanisms of formononetin STAT3 BAX EPHB3 TIMP1 CDK2 PTEN IGF1R ERG SRC CCND1 FGF2 FGFR2 PMC8292425__F1 Sequence variant in the diacylglycerol O-acyltransferase 2 gene influences palmitoleic acid content in pig muscle DGAT1 DGAT2 SCD MGAT2 PMC7851265__F3 rTSMS regulates functional protein synthesis and pathways CDC42 ARHG THY1 SLC25A4 HEL-S-99n PRDX3 PCSK1 NME2 MBP MOG HEL-S-2a HEL-S-44 STMN4 NCDN BASP1 HEL-S-67p ANXA2 HEL-S-94n RAC1 HEL-117 SDHB GSTM1 RHOB HEL-S-69p PS1TP5BP1 PMC6551881__F8 Over-expression of miR-195-5p blocks the PSAT1-mediated GSK3B/Beta-catenin signaling pathway, thus inhibiting angiogenesis and reducing chemotherapy resistance to DDP GSK3B PSAT1 CTNNB1 PMC8308291__F1 Omega-3 Supplementation and Heart Disease: A Population-Based Diet by Gene Analysis of Clinical Trial Outcomes ELOVL2 LOX HEL-S-5 GLA FADS2 ELOVL5 FADS1 ADA PMC9554963__F1 Improving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways EGFR EIF2A MYC PMC3343318__F6 PLC signaling in B cells RYR3 SYK BTK TIRAP BCR STIM1 TLR4 BLNK LYN MYD88 PMC8364365__F5 Crucial Roles of Intermediate Metabolites in Cancer KYNU KMO AHR AFMID PMC8273223__F1 Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play HEL-S-22 GSTT1 CYP3A4 MPO PMC8014161__F11 Network Meta‐Analysis on the Mechanisms Underlying Alcohol Augmentation of COVID‐19 Pathologies STAT3 HMGB1 CDK5 IGF1 LAT AMT PTEN UNK PMC5697091__F7 List of genes involved in Toll-like receptor pathway generated by KEGG of the differently expressed genes between Cryptocaryon irritans-infected and non-infected S CD40 CD80 TIRAP CTSK TLR9 CD14 CPO IRF3 IRF7 TRAF3 TRAF6 IRAK4 RAC1 MYD88 TLR3 IL16 TLR4 PDC LBP FADD PMC9305664__F2 Non-Coding RNAs in Primary Biliary Cholangitis TBR1 SMAD2 PDC TGIF2 TNF PMC5697091__F8 List of genes involved in Toll-like receptor pathway generated by KEGG of the differently expressed genes between Cryptocaryon irritans-infected and non-infected S CD40 CD80 TIRAP CTSK TLR9 CD14 CPO IRF3 TRAF3 TNF TRAF6 IRAK4 RAC1 MYD88 TLR3 TLR4 LBP FADD PMC5697091__F9 List of genes involved in the complement and coagulation cascades pathway generated by KEGG of the differently expressed genes between C VWF C6 FH C7 CPB2 HEL-S-62p PLG F7 CR2 CS TFPI C2 F2 F10 F3 C9 PC A2M DAP F8 F9 PMC7285805__F1 STAT6 modulates pro-colitis and pro-cancer responses PMC7285805__F2 Targeting the IL-4/IL-13/STAT6 signaling pathway for cancer therapy IL13RA1 JAK3 JAK1 TYK2 IL13RA2 PMC5712330__F3 Canonical and non-canonical NFKB signaling pathways CD40 CARD11 RELB IRAK1 TRAF3 TRAF6 IRAK4 MYD88 SHARPIN BCL10 BCR RELA BIRC2 TRAF2 BIRC3 PMC5712330__F4 Regulation of the NFKB signaling pathway by MALT1 and BIRC3-MALT1 TNFAIP3 BCL10 CARD11 RELA RELB TRAF6 CYLD TRAF2 BIRC3 PMC5712330__F5 Targeted therapy in extranodal marginal zone lymphoma IKZF1 TNFAIP3 CARD11 MTOR IRF4 MYC TRAF6 IRAK4 MYD88 BCL10 BCR BCL6 IKZF3 BIRC3 PMC7957700__F1 Normal CD8+ T Cell Response ZAP70 CD80 CD37 LCK PMC6045948__F2 Signal transduction pathways involving c-fos RASGRF1 MAPK1 MAPK3 PMC3905229__F2 Wnt/GSK- 3B pathway MAP1B APC GSK3B PMC9234177__F7 Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment STAT3 BAX PMC6107220__F1 Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies SMS SRM SMOX PAOX PMC8147372__F6 Transcriptomic and metabolomic characterization of post-hatch metabolic reprogramming during hepatic development in the chicken HK3 CS PC GCK PFKM CIT RPEL1 G6PC2 FH HEL-S-133P MAL LDHB SDHD SDHA G6PC3 PGAM1 SDHB DLAT PDHA1 HEL-S-304 RPIA HEL-S-68p OGDH PFKP HEL-S-162eP PDC DLD PFKL SDHC PMC8875399__F1 F ig . 1.“Find-me” signals and their respective receptors for apoptotic and necrotic cells PANX1 THBS1 CXCL1 ABCA1 S1PR5 S1PR4 S1PR1 S1PR3 MFGE8 S1PR2 CX3CR1 CX3CL1 FPR1 PMC3898811__F7 Schematic diagram as summary of the present investigation CSA2 HEL113 HEL-S-133P HEL-S-68p MMP2 MMP9 PMC4581028__F1 Regulation of cell metabolism by proto-oncogenes and tumour suppressors RHEB TSC2 PTEN MDM2 MYC PMC7874475__F9 Protein-protein interaction network MTHFD2 FBN1 CALD1 TGFBI FAM13C NCAPG PNPT1 ADAMTS3 PRRX1 VCAN RAD54B SFMBT1 CDH11 CDC45 MAF PXDN SMC2 ZEB2 SDC2 SMC4 PMC9513389__F1 Cooperation effects of radiation and ferroptosis on tumor suppression and radiation injury POR STEAP3 GPX4 LPCAT3 FACL4 DHODH PMC3607786__F1 MTOR signal pathway in autism spectrum disorders RHEB TSC2 TSC1 RYK PTEN EIF4E PMC8888700__F5 Environment-dependent oncogenic activities of PcG proteins GATA2 EAF2 RXRA PRC1 CCR2 APP MICA MICB CCL2 PMC4048946__F1 Metabolic pathways regulating oxidative stress and endosome traffic controlling the recycling of receptor and adaptor proteins between the cell surface and lysosomes CD2 PLCG1 CBL LAT STIM1 CD2AP MTOR MIP LCK PMC8638142__F10 LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway PKMYT1 APC SOX2 YY1 PMC8888700__F2 Polycomb recruitment and action on target genes RBBP7 EED CBX2 RBBP4 BAHD1 PRC1 JARID2 PMC4490472__F2 Regulation of CUL5, JAG-NOTCH, TNKS2, and PTEN-PI3K-AKT cell signaling by members of miR-17~92 and miR-106a~363 clusters in cervical cancer LEP TNKS CUL5 APC LRP5 PTEN MTOR SKP2 CTNNB1 PMC5923449__F2 EV71 induces multiple cellular inflammatory signals and Ca2+-dependent signals EGF JUN MAP3K7IP1 COX2 TAB3 SRC PMC4490472__F3 Regulation of JAG1-NOTCH1-uPA, Cyclin D-CDK4/6-p21-p27, and PI3K-PDK1-AKT1 cell signaling by members of the miR-23b~27b~24-1, miR-29a~29b-1, miR-29b-2~29c, miR17~92, miR183~96~182, and miR-302s clusters CDK6 FOXO1 PLG PTEN YY1 SKP2 CDK4 PMC4490472__F1 Regulation of MAPK, PI3K-AKT, and G2-M checkpoint by members of the family miR-125 and members of miR-let-7c~99a, miR-125a~let-7e~99b, miR-100~let-7a-2, and miR-206~133b clusters in cervical cancer CDC42 CDC2 AURKA ATR TRIB2 C13orf34 ATM ARHA MDM2 MTOR PLK1 PMC4784301__F4 Synthetic model of Plasmodium quiescence metabolism LIPA SDHA FH C2 CS PMC12110659__F4 Targeting autophagy to enhance anti-PD-1/PD-L1 therapy CD44 NBR1 PMC9002053__F3 Translational Control of COVID-19 and Its Therapeutic Implication SRP54 TBK1 EIF4B MAVS XRN1 STAT2 IRF9 ELF2 EIF5 IRF3 STAT1 ELF1 ELF5 ELF3 PMC8494307__F7 NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis IL1R1 NLRP3 IL1B PMC6850186__F6 How ablation of IKBNS affects B cell activation and PC differentiation BCR TLR4 RELA PMC12110659__F1 Immune Resistance Mechanisms IL10 CCL28 IL13 IL18 IL4 IRF1 IL6 IL5 PMC12110659__F2 Autophagy regulation by glycolysis RHEB STAT3 HEL-S-162eP MTOR PMC4030113__F2 Abnormalities in IRS1 interaction in the KEGG PI3K-AKT signaling pathway (PI3K-AKT) SYK BAD CREB3 DDIT4 CRTC2 PTEN PPP2CA MAP2 MTOR MYC CSF3 CSF3R CHUK MDM2 RPS6 CASP9 GNB5 TNFSF6 RBL2 CD19 IRS1 HRAS TSC2 RXRA BCL2 CDC37 GRB2 PMC2890584__F6 Mu-Opioid Receptors Transiently Activate the Akt-nNOS Pathway to Produce Sustained Potentiation of PKC-Mediated NMDAR-CaMKII Signaling HINT1 PDK2 SRC PMC4030113__F3 Abnormalities in IRS1 interaction in the KEGG Oxidative Phosphorylation metabolic pathway COX7B NDUFB2 NDUFA12 ND4L COX10 NDUFA7 NDUFA13 NDUFAB1 NDUFA10 COX17 NDUFS3 NDUFA11 COX2 ND6 NDUFB4 WAS COX3 NDUFB7 ND3 ND2 NDUFC2 ND4 IRS1 SDHD SDHA NDUFB10 SDHB CYB SDHC PMC3703460__F3 Signaling Pathways That Control mRNA Turnover EGF GRB2 PIN1 PMC3703460__F4 Signaling Pathways That Control mRNA Turnover DGCR8 DROSHA PMC5835061__F1 Schematic presentation of synthesis and maturation of BDNF PLG MMP2 MMP9 BDNF FURIN PMC9547753__F3 Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options HMGB1 FAS GSDMD ATG12 GPX4 PMC6209965__F3 Natural compounds as anticancer agents in TNBCs: Mode(s) of Action JUN EGFR APC GSK3B SMO MTOR MYC FOS CTNNB1 PMC11005058__F2 Adipocyte leptin promotes lymphocyte activation and TH17 differentiation IFNG STAT3 BCR LEPR PMC6737310__F4 Inflammatory mediator network between cytokines and signaling pathway in liver fibrosis STAT3 IL10 IF2B1 IL6 PMC6698603__F6 Possible mechanism of drug resistance related to miR-326 in pediatric acute lymphoblastic leukemia (pALL) leukemic cells ABCA2 SMO ABCA3 PMC6976905__F7 Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/Beta-Catenin Signaling Pathway in GC FZD4 EZH2 CCND1 CTNNB1 PMC6976905__F1 Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/Beta-Catenin Signaling Pathway in GC FZD4 EZH2 CCND1 CTNNB1 PMC10529739__F3 Signalling pathways and transcription factors involved in MSC senescence SIRT7 NMNAT1 SIRT4 SIRT5 NAMPT MTOR SIRT2 CTNNB1 SIRT3 MSC SIRT1 NMNAT3 SIRT6 PMC5105076__F8 Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism STAT3 COX1 COX2 PMC3365861__F6 Opposing roles of Myd88 and RAGE in extensive liver resection STAT3 PIM1 GLO1 MYD88 PMC9325148__F2 Succinate as a New Actor in Pluripotency and Early Development? COX1 COX2 C2 SUCNR1 MFF PMC4557106__F3 Pharmacologic modulators of the Hippo pathway LATS1 LATS2 YES1 APC RHO TBX5 PMC1705980__F2 Schematic model of autophagic regulation PTEN MTOR PMC2134905__F2 The p53 pathway and IGFBP3 BAX IGF1 PMC6430710__F5 Complementary pathways in DNA double strand (ds) break repair and PARP inhibitor response RAD51 BRCA1 BRCA2 POLE PARP1 PMC10743706__F2 Biosynthetic pathways of BR BROX CS CPD PMC12251215__F3 In esophageal and gastric cancers (EC and GC, respectively), circRNAs modulate Wnt/Beta-catenin signaling through various mechanisms FZD3 ITCH GC SRXN1 SOX4 CTNNB1 PMC2517296__F1 The co-ordinated activation of pro-inflammatory signalling pathways by TLR ligands and the pro-inflammatory cytokines TNFA, IL-1 and IFN TRADD TRAF5 PTEN TRAF6 TRAF2 MYD88 PMC7962935__F1 Downstream signaling of Frizzled proteins (Fzds) APC GSK3B LRP5 LRP6 RHO CTNNB1 PMC12251215__F2 Wnt Signaling Pathways: canonical (Wnt/Beta-catenin) and non-canonical (Wnt/planar cell polarity, PCP and Wnt/Ca2+) pathways ROR1 APC ROR2 LRP5 LRP6 ARHA RAC1 DAAM1 CTNNB1 PMC3753234__F7 Fibroblast Growth Factor 2 Causes G2/M Cell Cycle Arrest in Ras-Driven Tumor Cells through a Src-Dependent Pathway ARHA SRC FGF2 PMC8314420__F2 Genetic syndromes with vascular malformations – update on molecular background and diagnostics ENG SMAD1 DKFZp781O1323 ALK SMAD4 PMC2688657__F5 Growth signal pathway MAX RASSF2 EGF JUN TGFA FYN EGFR GRB2 MYC PMC2688657__F3 Apoptosis pathway KRT18 BAX CASP9 BAD FAS CASP8 TRADD PTEN CASP6 CASP3 BCL2 ATM FADD PMC2688657__F1 Antigrowth signaling pathway and cluster around SMAD proteins SF3B2 SMAD9 PSMD11 SMAD2 SMAD4 MYC TGFBR1 TGFBR2 NR2A1 CDK6 RHOD PAPOLA GPNMB CDK2 MDM2 CDK4 PMC8282792__F8 Proposed model for the dysregulation DEPDC5-mTORC1 axis in the pathogenesis of alcohol-induced hepatic steatosis NR1C1 KLHL22 DEPDC5 PMC3757153__F2 Treatment advances in neonatal neuroprotection and neurointensive care FAS CAD APAF1 PARP1 FADD PMC9153171__F2 Metabolomic, proteomic and lactylated proteomic analyses indicate lactate plays important roles in maintaining energy and C:N homeostasis in Phaeodactylum tricornutum MAL CS CIT PMC7672569__F2 Targeted signalling pathway involved in endothelial cells (ECs) activation and vascular smooth muscle cells (VSMCs) proliferation and migration during intimal hyperplasia PGR HEL-S-11 ARHA VEGFA SRC PMC7926043__F8 Mapped proteins and genes in the glucocorticoid receptor signaling pathway, the role of JAK2 in the hormone-like cytokine signaling pathway, and the TNFR1 signaling pathway FKBP5 IL19 CASP3 PTPN11 JAK1 TNF TRAF2 PMC6032287__F1 Phoenixin-20 stimulates the mRNA expression of GnRH, GnRH receptor, Kiss1 peptide, and GRP173 via the cAMP-PKA pathway and CREB phosphorylation mediated by the GPR173 KISS1 GNRHR EBP GPR173 PMC10944245__F9 Cytotoxic effect of flavonoids related to MAPK and PI3KAkt pathways EGF BRAF PTEN PMC8819497__F9 DDR‐dependent matrix‐mediated drug resistance (MMDR) to MAPK‐targeting therapies in melanoma DDR1 RELB DDR2 PMC3899934__F2 Farnesoid X receptor–Acting through bile acids to treat metabolic disorders PCSK9 LPL TG ABCG8 ABCG5 CYP8B1 CYP7A1 LDLR PMC9673319__F3 Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease BACE1 ADAM10 SNX27 PACS1 PMC9673319__F8 Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease NGF PSD PSEN2 ABO APP SORCS3 PICK1 PSEN1 PMC22667__F1 Pheromone response pathway in yeast and summary of epistatic interactions with STE4 and STE11 CDC42 FAR1 CLN3 PMC9020878__F12 Huangqin Tang Interference With Colitis Associated Colorectal Cancer Through Regulation of Epithelial Mesenchymal Transition and Cell Cycle CCND1 CDK4 CTNNB1 PMC9673319__F6 Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease VPS35 ADAM17 PSD SORCS1 ABO BDNF PMC8533944__F2 Crosstalk between KRAS, SRC and YAP Signaling in Pancreatic Cancer: Interactions Leading to Aggressive Disease and Drug Resistance LATS1 EGFR PTF1A GRB2 AREG MYC FOS PMC10740436__F3 Comparative Serum Proteome Profiling of Canine Benign Prostatic Hyperplasia before and after Castration CDC42 DVL1 FRAT1 TNK2 UBC EGFR GSK3B GRB2 PIGR PMC11913433__F8 M6A modification-mediated MTHFD2 upregulation drives tumor-promoting effects via the PEBP1-RAF1/MEK/ERK signaling cascade MTHFD2 METTL3 IGF2BP2 HEL-S-34 PMC8492102__F4 Unboxing the molecular modalities of mutagens in cancer TBK1 ATR CGAS IRF1 PMC3259192__F2 Sphingolipid Signaling and Hematopoietic Malignancies: To the Rheostat and Beyond STAT3 BAX GAL BAD SPHK1 PMC4389563__F1 Time-resolved metabolic reprograming during pro-inflammatory macrophage polarization COX2 F2 TLR4 IL6 PMC6087673__F1 Apoptosis in Acetaminophen Hepatotoxicity BAX FAS CAD FADD PMC8555029__F4 Cellular mechanosignaling in pulmonary arterial hypertension TRPV3 NOTCH3 PMC4625494__F1 Tubulin folding cofactor D (TBCD) cooperates with Dscam during neuronal morphogenesis.(A, B) Schemes of wild-type (A) and TBCD mutant (B) projection neurons DSCAM TBCB WAS TBCD MB PMC6747374__F8 Signaling pathways involved in the AVP-dependent myogenic differentiation MTOR AVP PMC7648688__F8 Network of potential core targets and signaling pathways in the treatment of IS by AT PPARG PIK3CA FABP1 PLA2G1B ACD MPO PRKCH PLA2G2A PLAT F2R F2 F3 PTGS1 MMP2 MMP3 IL1B NOS2 JUN PTGS2 MMP9 VEGFA TNF RAC1 NR1C1 NFE2L2 PTGES PMC8126512__F2 Intersection of COVID-19 and cancer: signaling pathways and treatment implications STAT3 BTK INA IL6R PMC3020075__F1 GPC5 Gene and Its Related Pathways in Lung Cancer GPC5 SUFU APC LRP5 LRP6 GRB2 CTNNB1 PMC9562648__F2 Mitochondrial VDAC1: A Potential Therapeutic Target of Inflammation-Related Diseases and Clinical Opportunities BAX TBK1 CGAS NLRP3 TLR9 AIM2 IRF3 IL1B PMC8892093__F6 Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD): A new avenue for modifying progression of AD pathophysiology CDK5 BACE1 APP PMC12178073__F4 Regulatory role of DEAD/H box helicases in the toll like receptor (TLR) signaling pathway TBK1 TLR9 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 DDX24 TLR1 DDX1 TLR3 DHX36 NFKB1 TLR4 RELA TLR8 TLR7 S100A9 PMC9207346__F4 Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence ATR RAD50 MRE11A ATM CDK4 PMC2834552__F11 Schematic diagram of AGE-induced CTGF expression is shown SMAD2 SMAD4 PMC7590703__F1 Functional and cell number defects in NK cells caused by different PIDs GATA2 RAB27A PRF1 WAS IL2RG LYST FHL2 IRF8 RTEL1 ADA PMC12074830__F5 TLR signaling pathway TLR4 IRF7 TRAF3 TRAF6 CP MYD88 PMC4317900__F3 Disease-specific mutations in T-cell large granular lymphocytic leukemia and natural killer (NK)/T-cell lymphoma IL15 STAT3 JAK3 JAK1 PMC4317900__F1 Disease-specific mutations in B-cell lymphoid neoplasms CCND3 SYK CD79A ECD TIRAP CARD11 BRAF IRAK1 BLNK PTEN MTOR MYC TRAF6 IRAK4 ID3 MYD88 BTK MAP3K7IP1 BCL10 MDM2 PMC2633398__F9 An epistatic pathway and genetic model for replication slowing in fission yeast SWI5 RAD51 DMC1 CDS1 SFR1 PMC10140952__F4 Selected molecular targets of resveratrol STAT3 AURKA BAX SYK EGR1 HGF EGFR ATG14 PTEN PLK1 STAT1 IGF1 ATG12 TLR4 CDK2 ABCG2 CYP3A4 ATG5 SIRT1 ABCB1 HEL-S-44 PMC9031669__F2 Key Signaling in Alcohol-Associated Liver Disease: The Role of Bile Acids AKR1D1 BAAT CYP7A1 GCA CYP7B1 CYP27A1 PMC7763461__F1 Toll-like receptor (TLR) signaling pathways TLR9 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 IL1B PMC8457632__F2 Antiviral Immune Evasion of SARS-CoV-2 SRP19 SRP54 STAT1 RAE1 IRF3 NUP98 PMC6404589__F5 Differential regulation of neurotrophin signaling pathway genes BAX CRK NGF BAD FRS2 GRB2 BDNF DAO PMC6100584__F1 Mechanism of Hedgehog pathway activation SUFU PTCH1 GSK3B SHH SMO MYC PMC4705542__F5 Schematic summary of the proposed photoneuroendocrine control of VGF expression CRABP2 VGF ARC PMC6100584__F2 Crosstalk of the Hedgehog pathway with other protumorigenic pathways EGF SOX2 BCL2 SMO MTOR IGF2 HES1 CTNNB1 PMC6651373__F3 The molecular mechanism of DAPK1 in AD NDRG2 APP PIN1 PMC10474047__F8 Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell motility during gonadotrope differentiation DAB1 ND1 NEUROD1 ZYX PTPN1 CSK ND4 NTRK3 PTPN11 SRCIN1 PTPN13 PMC8040299__F10 Pattern diagram HHT influence miR-18a-3p and AKT/mTOR signaling pathway BAX BCL2 MMP9 MTOR PMC9746897__F2 Pyroptosis: A new insight of non-small-cell lung cancer treatment IFNG HMGB1 GSDMD CASP8 NLRP3 GSDMC CASP3 GZMA GSDMB DFNA5 GSDMA TNF PMC10377067__F7 Metabolic Profiles Point Out Metabolic Pathways Pivotal in Two Glioblastoma (GBM) Cell Lines, U251 and U-87MG FAS GLS ACADS ACADM PMC5214967__F1 Biosynthesis of the lipid-linked oligosaccharide precursor for N-linked glycosylation and known defects in this pathway DPM2 RFT1 ALG3 DPAGT1 DPM3 ALG12 DOLK ALG6 ALG10 ALG13 DPM1 ALG1 STT3A STT3B PMC3830611__F1 Circuitry and biochemical basis for Tuberous Sclerosis symptoms: From Epilepsy to Neurocognitive deficits RHEB TSC2 TSC1 PMC3420937__F6 PTEN Negatively Regulates MAPK Signaling during Caenorhabditis elegans Vulval Development INSR EGFR PTEN GRB2 PMC8617589__F10 Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity STAT3 TXN TXNIP CEBPD SELENOM LCN2 PMC9200662__F7 Model for the role of the sequential modification of ERA by UFM1 and ubiquitin in the transactivation pathway UFM1 CCND1 PMC8016657__F2 Roles of Epac in synaptic plasticity, neurodevelopment, and cell death BRAF MTOR RAP2B PMC2999296__F2 Toll-like recepter 4 signaling pathway modified from Wikipedia Commons TBK1 TIRAP TLR4 CD14 IRAK1 TRAF6 LBP IRAK4 MYD88 PMC4335664__F3 The crosstalk between the IGF-1 system and estrogens in breast cancer IGF1 IGF1R MTOR IRS1 PMC7582192__F5 Targeting N-myristoylation for therapy of B-cell lymphomas CD79B SYK CD79A BCR ARF1 PMC5852553__F9 Rac signaling pathway CDC42 CD44 CDK5R1 JUN PC ARHA PMC8413680__AF1 LINC00941 promotes glycolysis in pancreatic cancer by modulating the Hippo pathway HEL-S-133P HK2 ENO1 YAP1 PMC4859755__F1 Phosphatidylinositol 3-Kinase: A Link Between Inflammation and Pancreatic Cancer SPINK1 PLG CFTR PTEN PRSS1 PMC6770103__F4 Differentially expressed genes in the neurotrophin signaling pathway between mandarin fish at CG and LG from a transcriptome analysis CRK FRS2 APP GRB2 SHE BDNF TRAF6 RAC1 PMC6585541__F1 Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar? CASP14 NLRP3 CXCR4 PMC6770103__F5 Differentially expressed genes in the cyclic AMP (cAMP) signaling pathway between mandarin fish in the control group (CG) and the learning group (LG) from a transcriptome analysis PPARG GHRL RHO AMH PMC6021501__F2 Role of apolipoproteins during early steps of hepatitis C virus (HCV) entry HRAS CD81 EGFR APOE LDLR APOB CLDN1 PMC2747008__F12 Induction of IFNB and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7 TBK1 STAT1 JUN STAT2 IFNAR2 IFNAR1 IRF3 ATF2 TRAF3 JAK1 TRAF6 TYK2 PMC7757029__F3 Alternations of signal pathway of MYC in breast cancer tumorigenesis JUN SP1 APC LRP5 LRP6 MYC KRAS FOS CTNNB1 RB1 CDK6 LEF1 CCND1 CDK4 PMC8523029__F1 12(S)-HETE/GPR31 Signaling Pathways TF RHO GPR31 PMC6607099__F1 Potential mechanism of Fn in CRC TIGIT GAL CTNNB1 MYD88 PMC1571066__F2 TGFB superfamily signalling pathway (see text for explanation) SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC6874443__F5 Functional enrichment analysis and construction of PPI network CD3D ARHH CXCR3 BATF CD2 MAP4K1 CD27 CCR5 IL2RG SIRPG GFI1 PSTPIP1 TBC1D10C TIGIT SLA2 SASH3 UBASH3A CORO1A SIT1 TRAF3IP3 CD3E IKZF3 LCK IL12RB1 PMC1571066__F5 Model of SMAD7 role in control of blood vessel calibre (see text for explanation) SMAD1 DKFZp781O1323 PMC6019445__F1 Schematic describing invariant natural killer T (iNKT) cell development and function in the thymus TEC CD24 CCL22 CD69 AIRE EGR2 GATA3 CD1D CCL17 PMC8344376__F2 SASP regulation BRD4 ATM IRF3 MTOR TREX1 STC1 DNASE2 GATA4 PMC3960235__F3 The Anti-Hypercholesterolemic Effect of Low p53 Expression Protects Vascular Endothelial Function in Mice CYP7A1 PMC6368838__F4 Identification of gene signature and critical pathway associated with childhood-onset type 2 diabetes WDR83 C14orf119 RAB10 MRPL35 ZNF420 EGR1 DEAF1 NKX3-2 NAMPT MZF1 PMC9190019__F6 Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation TGFA RBM4 EGFR RHBDF1 CTNNB1 PMC9034917__F9 Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment BAX BCL2 IL1B PMC3293036__F1 The Wnt signaling pathway in cancer cells RHEB TSC2 TSC1 APC GSK3B LRP5 LRP6 MTOR PMC9630943__F3 IL-33/ST2 immunobiology in coronary artery disease: A systematic review and meta-analysis TLR4 IL33 SIGIRR IRAK1 TRAF6 IRAK4 MYD88 PMC6928633__F3 Constructed metabolic pathway that integrated relative metabolite contents and gene expression for three different sizes (small, medium and large) of beech mushrooms PMC3139189__F1 Intrinsic pathway of apoptosis BAX BAD CAD BOK BMF BIK DIABLO PMC9274081__F2 Inflammation in Cardiac Remodeling After Acute Myocardial Infarction CRP NLRP3 IL1B PMC3139189__F2 B1/Fak/Src integrin signaling, cell survival, and suppression of anoikis BAD FYN HEL-S-28 BMF GRB2 SRC PMC3139189__F3 Common pathway of anoikis induction CASP9 BAD CASP3 BMF SRC DIABLO PMC7508434__F5 Diagram for the molecular mechanism STAT3 CXCL14 PMC3062538__F5 The regulation of IgA class switching CD40 TSLP TGFBI TGFB1 PIGR PMC6575164__F3 Possible mechanisms of action of targeted polyIC TBK1 MAVS TLR3 IRF3 TRAF3 EIF2A PMC5852553__F4 Phosphatase and tensin homolog (PTEN) signaling pathway BAD CBL PTEN GRB2 PMC11968285__F7 SONFH reveals that BMSC Piezo1 in response to elevated IOP regulates bone vascular homeostasis through CAM-NFAT1 signaling pathway CXCL12 PIEZO1 RUNX2 PMC8198713__F12 Novel Characterization of Constipation Phenotypes in ICR Mice Orally Administrated with Polystyrene Microplastics AQP3 MUC2 CFTR AQP8 PMC5973372__F1 Hippo信号通路。A：果蝇中的Hippo信号通路；B：哺乳动物中的Hippo信号通路。Hippo signaling pathway FAT4 ITCH ABL2 SOX2 RHO SKI LATS1 CD44 FRMD6 LATS2 CUL4A HMGCR AMOT NF2 PMC4940412__F4 Glycolysis superpathway gene expression profiles SDHD SDHA SDHB ENO1 SDHC PMC9147752__F2 Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration JUN MTOR NACA FOS PMC7698326__F1 GWAS of fibrosing disorders RAD18 ICOSLG CD80 MC1R LTA TGFB1 COL4A3 TNFRSF1A BANK1 PRKAG2 IRAK1 TERT MYO7A NOD2 SPIB CTGF ATG5 IKZF3 CAV3 TNLG1B IL12A UMOD CDH23 IL7R CTLA4 IL6 IRF4 TNF MYO1E DPP9 IL17RA ARHGAP31 NEDD4 IL1RN MUC5B NFKB1 CXCR5 STAT4 GCKR SERPINB2 STC1 IL12RB1 PMC9318662__F1 In Silico Approach in the Evaluation of Pro-Inflammatory Potential of Polycyclic Aromatic Hydrocarbons and Volatile Organic Compounds through Binding Affinity to the Human Toll-Like Receptor 4 TIRAP TLR4 CD14 MYD88 PMC10778111__F3 Non-coding (nc)RNA-regulated signaling pathways involved in gastric cancer invasion CDC42 DKK1 EGFR SMAD2 APC SMAD4 RHO MTOR PMC9138354__F1 Synergistic Cooperation between TGFB and Hypoxia in Cancer and Fibrosis APPL1 SMAD4 MMP2 IL6 RHO MMP9 TRAF6 PSEN1 APPL2 PMC9354699__F7 Inhibition of KIR2.1 decreases pulmonary artery smooth muscle cell proliferation and migration PCNA SMAD2 PMC6579679__F8 Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart SMAD2 SMAD4 ARHA PMC7734100__F2 How coronavirus disrupts signaling pathways (autophagy, ER stress, cytokine storm, and hypoxia) and induces cell death ULK1 ATF4 PLP2 EIF2A SKP2 XBP1 PMC8102340__F1 Project flow chart summarizing analyses and key results MAF1 TTC28 GPC3 EPHA7 AKR1D1 OR11H4 COL22A1 KY FSIP1 ST6GALNAC2 PRKDC EVI2B SMPDL3A ERCC5 CENPQ OSTM1 SDK2 SPTBN5 NOTCH3 NAT1 PMC4120684__F2 Comparison between recombinant Shh- and EVsShh+-activated pathways modulating angiogenesis and apoptosis in endothelial cells HGF SHH SMO ARHA PMC7899295__F3 WNT pathway mutations underlie vitreoretinopathies that have phenotypic overlap with pathologies seen in the DC spectrum diseases TSPAN12 LRP5 CTNNB1 PMC2655360__F7 Pathway maps generated using GenMapp depicting increased glycolytic protein expression in differentiated intestinal epithelial cells relative to crypt cells PRLR GOT2 HEL-S-278 LDHB FAP PDHA1 PGAM2 DLAT ALDOB HEL-S-162eP PC DLD PAH GCK HEL-S-87p PFKM PMC4202134__F7 Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk BAX BAD FAS PTEN MDM2 FADD PMC8815749__F5 Bioenergetic Evolution Explains Prevalence of Low Nephron Number at Birth: Risk Factor for CKD TSC1 ULK1 MTOR VHL PMC6981291__F1 Crosstalk between Nrf2 signaling and Mitochondrial function in Parkinson’s Disease TF HEL107 HMOX1 GCLM HK2 HEL-S-162eP PRX ABCB7 FES ENO1 ME1 HEL-S-44 PMC5080294__F2 Proposed model for the targeting of NRAS-mutant melanoma by ERB ligands CCND3 NRAS BLM CCND1 PMC3196718__F4 Network of upregulated genes in C2C12 cells treated with rhBMP2 and rhBMP7 using the STRING 9.0 pathway analyzer ECSIT PLOD1 SMAD1 BAD ID2 WNT3A NKD2 HTRA1 GLIS1 LRP6 GRN ID1 ID3 CTNNB1 GLIS3 POSTN CFDP1 FOXO4 DKK1 AXIN1 KAZALD1 SIRT1 CREB1 DAAM1 PMC9350078__F3 NK cell dysfunction is linked with disease severity in SARS‐CoV‐2 patients IL18 TNF CD34 PMC6668540__F2 TLR signaling pathways IL16 IRF3 IRF7 TRAF6 IRAK4 PMC2727911__F1 Activation pathways of the complement system and complement regulatory proteins MASP1 C6 CD59 C7 MASP2 HEL-S-62p C2 C1S C4B_2 PMC3741439__F1 The catecholamine biosynthetic pathway TH PNMT PAH DDC PMC2268064__F2 Signalling pathways leading to the phosphorylation and inhibition of glycogen synthase kinase 3 (GSK3) EGF GRB2 MTOR PMC4017002__F8 PPARB/D promotes HRAS-induced senescence by potentiating p-ERK and repressing p-AKT PDPK1 HEL-S-28 MDM2 PMC9621439__F2 Mammalian and basal innate immune signaling via NFKB CGAS IRF3 IRF7 PMC2268064__F3 Regulation of the transcriptional co-regulator Beta-catenin APC LEF1 CTNNB1 PMC5825873__F2 Pathways that regulate mTORC1 and mTORC2 signaling RHEB EGFR PTEN GRB2 PMC3075080__F3 Proposed ACE2/ANG-(1–7)/Mas signaling pathways in the central nervous system STAT3 MLN ACE2 PMC6164903__F3 Innate immune response to baculovirus infection in non-immune cells TBK1 CGAS IRF3 PMC6164903__F2 Induction of innate immune response by viral infection TBK1 TLR3 TLR9 IRF3 IRF7 TLR7 MYD88 PMC11172187__F1 Gliogenic switch during brain development GFAP SOX9 HES1 NFIA PMC4961994__F2 Summary of TGFB signaling during EMT HMGA2 FOSB JUNB TWIST2 ZEB2 TWIST1 TGFBR1 PMC11703747__F2 Cellular metabolic pathway involving GOT1 HIF1A FOXP3 KRAS SIRT1 PMC6337314__F2 TREM2 activation and downstream signaling TREM2 SYK ADAM17 TYROBP LAT ADAM10 PMC10534826__F2 Impact of Opioids on Cellular Metabolism: Implications for Metabolic Pathways Involved in Cancer TH COMP GLS PC CS PMC6135256__F4 The effects of NBUVB on the bulge and epidermis of human vitiligo skin during repigmentation TNC IGF2BP1 THBS1 SNAI1 SOX9 FZD7 GJB6 SFRP1 CTNNB1 PMC4603759__F6 Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism GPAM GPAT2 RRM1 GCLC RRM2 RRM2B HEL-S-64p PMC6631457__F8 Schematic showing that exosomes carrying miRNAs promote NDV infection STAT1 MAVS IRF3 IRF7 PMC10377020__F1 ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review KEAP1 ATF4 XBP1 PMC10377020__F2 ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review DCSTAMP KEAP1 NFATC2 SIRPB1 MAF CTSK ATP6V0D2 OSCAR NFATC1 MMP9 SRC TRAF6 PMC3320973__F8 Wnt signaling regulation induced by cell surface HSPG desulfation during dentinogenesis DSPP SULF1 SULF2 WNT10A PMC7369957__F1 Canonical Wnt pathway APC LRP5 LRP6 PMC5902714__F8 Summarized scheme for the regulation of spexin on bile acid pathway NR2A1 CYP8B1 BAAT GALR3 GCA GALR2 CYP27A1 PMC12122839__F2 Generation and metabolism of sulfur-containing biomolecules RHD HEL-S-61p MTOR DAO PMC4102744__F1 Cytoplasmic/traditional and nuclear modes of the epidermal growth factor receptor (EGFR) signalling pathway STAT3 EGF EGFR CCND1 PMC12122839__F3 Sulfide signaling pathway RHEB TSC2 TSC1 KEAP1 SMAD2 APC SMAD4 ARHA CTNNB1 PMC4632082__F6 CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity CD44 NFATC1 SRC TRAF6 PMC6647228__F2 Schematic presentation depicting the energy metabolic pathways through which AMPK controls the activation of MDSCs STAT3 CD36 NFE2L2 MTOR PMC6924059__F4 ARHGAP9-mediated regulation of the MAPK signaling pathway in BC EGF EGFR PMC7801920__F2 Related molecules, genes, signaling pathways and biological function in HCC of miR-200 family BMI1 RBBP4 PBX3 PTEN FOXA2 ZEB2 RHO PMC4445742__F4 Model depicting PPP1R12A/PP1cD in the insulin signaling pathway GRB2 IRS1 PMC4276281__F2 Schematic of the major pathways of serine metabolism in a mammalian liver PHGDH PSAT1 PSPH PMC5122694__F3 Canonical pathways by IPA: antigen presentation pathway in the NC vs IFNG HEL-S-99n MHC2TA PMC4927194__F2 Diverse extracellular signaling pathways are regulated by A disintegrin and metalloproteinase (ADAM)-mediated shedding events EGF TGFA DLL4 AREG IVL CD44 NRG1 HBEGF EREG ADAM17 BTC ADAM10 VCAM1 PMC3240717__F9 Pro-inflammatory Cytokine/Chemokine Production and Breast Tumor Invasion CD44 IL1B MYD88 PMC6942368__F7 Role of liraglutide in regulating hCMSC paracrine and SPC expression TCF4 FGF10 CTNNB1 PMC6558915__F10 Schematic presentation of the anti-TNBC mechanism of Ilamycin C STAT3 BAX MMP2 MMP9 PARP1 PMC5122694__F1 IPA Canonical Pathway analysis showing the interferon signaling pathway across the NC vs SOCS1 IFNG BAX STAT2 PSMB8 IRF9 MX1 JAK1 TYK2 PMC5122694__F2 Canonical pathways by IPA: antigen presentation pathway in the NC vs ALB IFNG HEL-S-99n PMC2893543__F4 Schematic overview of costimulatory receptors and their ligands CD40 ICOS CD27 TNLG8A PMC8961590__F1 Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases RBFOX2 DGCR8 LIN28A INSR GSK3B PTEN RBFOX1 MTOR HNRNPK DROSHA IRS1 PMC10522861__F7 Analysis of the response mechanisms of Pinellia ternata to terahertz wave stresses using transcriptome and metabolic data BIN2 TPM1 EBF2 PMC5007826__F6 Working model of PRL-3 involvement in TNF-R1 pleiotropy TRADD TRAF2 FADD PMC6380503__F1 Metabolites as regulators of insulin sensitivity and metabolism MAP3K7IP1 TLR4 PC IRF3 IRS1 MYD88 PMC5374731__F2 Schematic summary of genetic abnormalities in ATL cells TP73 STAT3 CARD11 ARHA IRF4 GATA3 PLCG1 HNRNPA2B1 BCL10 KY PLCG2 IKZF2 GPR183 NOTCH1 PMC8416371__F8 Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis RAN BAD tal-1 C1S INA ChAT HEL-S-11 PMC8416371__F9 Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis MAX TEC TRADD APP TNF PMC8334720__F1 Interplay Between mTOR and Hippo Signaling in the Ovary: Clinical Choice Guidance Between Different Gonadotropin Preparations for Better IVF RPS6 CYR61 CCND2 PMC4316815__F2 Regulation by zinc of the ERK1/2 signaling cascade CSK GPR39 BDNF PMC6927014__F6 Protein–protein interaction and pathways analysis TES CD40 SYK LTA TRADD LAT CARD11 PTEN TRAF3 MYC TNR PCK1 BFAR CSF3R BCL2L1 COX2 EPOR BCR ITGA6 ATM MDM2 YWHAG IL1B VWF THBS1 LAMC2 ITGB7 FRK BLNK RBL2 IL7R ITGB3 TNF PCK2 LTB TRIM25 LYN VCAM1 LBP LCK PMC5443811__F8 Illustration of the chondroprotective effects of sUA and the mechanisms underlying these effects ADAMTS4 IL1B PMC7802442__F4 Case of UDP-Galactose 4′-Epimerase Deficiency Associated with Dyshematopoiesis and Atrioventricular Valve Malformations: An Exceptional Clinical Phenotype Explained by Altered N-Glycosylation with Relative Preservation of the Leloir Pathway GAL PMC6570467__F6 Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining MTAP HEL-S-133P PNMT GFPT1 NAMPT FADS2 HEL20 HEL-S-97n ACSL1 GSTM3 HEL-S-68p UGDH IDI1 P4HA1 PMC3343040__F6 Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease FXYD5 RAB30 CCDC62 SLC1A3 PCOLCE TAP1 SMPD1 SLC27A1 MMP2 PSMB10 A2M HEL-S-26 TM7SF2 GHR CYP27A1 HES1 LPL CYP51A1 ACOX1 GOT2 NAMPT SREBF2 STARD4 ACSL1 HMGCR FER PSAP TCF20 F11R CXCL12 TIMP1 EBP INSIG1 LITAF F2R NR3A2 FKBP1A DUSP16 HBB FCGR2A HLA-DMB HMGB1 STAR ANXA6 PNPLA2 ME1 CYP1B1 HTATIP2 SDC1 HLA-DMA HEL-S-130P ACTN4 C1QA LIPE STAT4 SLC39A6 SLC36A1 PMC3343040__F7 Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease PLB1 HLA-DMB CXCL12 TIMP1 MAPK13 HEL-S-53e LGALS3BP SPHK1 NAMPT ANXA11 MDM4 DNAJC15 HMGCR HEL-S-130P F2R ACTN4 NR3A2 EDN1 MMP2 LIPE GPR176 PKIA PMC3763401__F1 Crosstalk between COX-2 and EGF signaling pathway in CRC EGF COX1 EGFR CCR7 GRB2 PMC9698582__F11 G Protein-Coupled Receptor 37L1 Modulates Epigenetic Changes in Human Renal Proximal Tubule Cells GPR37L1 PRKDC MTOR PMC4331529__F8 miR-30 Family microRNAs Regulate Myogenic Differentiation and Provide Negative Feedback on the microRNA Pathway SNAI2 SMARCD2 TNRC6A PMC5715847__F1 B‐Catenin‐dependent pathway APC GSK3B CTNNB1 PMC5715847__F2 Wnt/PCP pathway JUN ROCK1 ARHA RAC1 DAAM1 PMC6824464__F1 Glycolysis and pentose phosphate pathway HEL-S-133P HEL-S-162eP PFKM PMC8039141__F2 The different mechanisms involved in Senescence Associated Secretory Phenotype (SASP) regulation BRD4 IL1R1 CGAS TRAF3IP2 ATM MTOR TRAF6 GATA4 CEBPB PMC9203716__F3 Case Report: Extensive Tumor Profiling in Primary Neuroendocrine Breast Cancer Cases as a Role Model for Personalized Treatment in Rare and Aggressive Cancer Types STK11 SGK1 EBP BCL2 POLI PTEN PMC9115384__F3 Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application SKIL CCL5 CXCL10 PMC9115384__F1 Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application NBR1 ATG3 ATG16L1 ATG12 UVRAG ATG14 MTOR STX17 ATG5 ULK2 PMC5715847__F3 Wnt‐cGMP/Ca2+pathway CDC42 NLK CTNNB1 PMC8080617__F3 Active D-secretase is the trigger for both AD and PD ALDH2 SRPK2 PMC7914561__F1 Methionine cycle HEL-S-61p PMC9312434__F3 Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury STAT3 GSK3B LYN SRC PMC3615463__F1 Phosphoinositide 3-Kinase Inhibition in Chronic Lymphocytic Leukemia SYK BTK BCR PTEN LYN MTOR PMC3799998__F1 Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila ATG101 ATG10 ATG3 PIK3R4 ATG12 ULK1 UVRAG AMBRA1 ATG14 MTOR ATG5 ULK2 PMC9622871__F8 Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions RPE PIG59 MB PMC7894463__F2 Lumped network of the carbon metabolism of Rhodobacter sphaeroides, including pathways for substrate uptake and product formation C6 IPP HEL-S-62p C2 MAL CS PMC5306179__F1 Canonical and alternative pathways for NFKB activation BCR RELB DAP REL TNF PMC6650903__F4 Schematic plot of significantly differentially expressed genes involved in GA metabolism and signaling under CK, CCC, and PBZ treatments in roots and shoots PIF1 CP PMC7760945__F3 Intra-articular (IA) delivery of cargo-loaded nanoparticles for the treatment of OA IL18 IL1B PMC9465182__F1 Dysregulated lipolysis and lipophagy in lipid droplets of macrophages from high fat diet‐fed obese mice BCL10 PLIN1 CARD9 PMC2490739__F8 Scheme summarizing the differential effect of PARP-1 inhibition versus silencing on SSB repair via the BER pathway SPR PCNA SSB PMC9184651__F4 Signaling pathways of chronic kidney diseases, implications for therapeutics SMAD2 CXCR4 NOX4 CTNNB1 PMC3009741__F3 Bioinformatics Analysis of Macrophages Exposed to Porphyromonas gingivalis: Implications in Acute vs. Chronic Infections TLR4 NOD2 NOD1 CCL2 TNF MYD88 PMC6905557__F6 Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound CDC42 CIB3 MLH3 RFC1 GPN2 PKP1 MCM2 PMC4530997__F1 Selective delivery of ITCs to bladder on oral consumption and modulation of cellular targets by ITCs in BC cells and tissues EGFR PMC7405402__F2 Cell cycle of SARS‐CoV‐2 in the host cells TMPRSS2 NPS GAL HEL-S-69p ACE2 PMC5869526__F1 Interferon-like antiviral response RHD ADAR CGAS MAVS TYK2 MYD88 PMC6476530__F1 Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy TSC2 TSC1 CAB39 CDKN2D CDKN2B MTOR PLK1 PMC10313451__F6 Imipramine mechanism of action in breast cancers ATR BRCA1 ERG CDK4 PMC3315209__F6 Speculative model for the role of the Hippo pathway in germ cell tumorigenesis and reprogramming LATS2 DND1 PMC3494597__F1 Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells UBE2M NAE1 MTOR ATG5 DEPTOR PMC5877528__F6 The AR induction pathway in ‘T337’ basal cuttings ARR3 XK CLU HEL-S-162eP PMC8418153__F2 Ferroptosis: A Trigger of Proinflammatory State Progression to Immunogenicity in Necroinflammatory Disease TF IREB2 SLC3A2 GPX4 HEL-S-102 PMC9458733__F4 Metabolomic alterations in the blood plasma of older adults with mild cognitive impairment and Alzheimer’s disease (from the Nakayama Study) NAGS ASL SMS AZIN2 OAZ1 OAZ2 SRM SMOX OTC ARG1 OAZ3 ARG2 PMC9523169__F3 Iron dyshomeostasis and ferroptosis in Alzheimer’s disease: Molecular mechanisms of cell death and novel therapeutic drugs and targets for AD HERC2 FTH1 PMC3978582__F4 Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and treated discs MMP14 HK2 PCP4 HEL-S-97n CRIP1 LMO7 SPRY2 CBL HEL-S-112 PFKP HEL-S-49 SLC39A8 SIRPA CHST12 PMC3978582__F5 Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and experimental discs AEBP1 BCR c-fgr NFKB1 RELA TANK NOD1 MAP2 HP IL23R CYBB PMC3065471__F3 Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map OGT FTL MAF UBB PMC8669610__F4 TGFB Signaling and Resistance to Cancer Therapy CCL5 FOXP3 CCL2 PMC6304490__F2 Examples of in vitro molecular action of quercetin (Q) in cited cellular experiments JUN TGFA WAS FOS PMC7164363__F7 EphB4, TNFR2 and ERK/MAPK signaling pathways TRAF3 TRAF2 PMC8665957__F1 Review: the effect of light on the key pigment compounds of photosensitive etiolated tea plant POR CPOX UROD UROS PMC3978582__F3 Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and treated discs SIK1 EGR1 MXD1 MARCKS MNS1 GLRX CD44 HMOX1 EZR ITGA1 E2F6 ERRFI1 RAB1 GADD45A CREB1 PMC8669610__F1 TGFB Signaling and Resistance to Cancer Therapy TRAF4 RHO GRB2 MTOR TRAF6 PMC8669610__F3 TGFB Signaling and Resistance to Cancer Therapy HMGB1 USP27X SMAD2 HERC3 SMAD4 ABCG2 SMURF2 PMC4529925__F3 Model of SAM68 interaction with pre-mRNAs and splicing regulation CD44 BCL2L1 MTOR SRC PMC4940389__F1 Regulation of HH and Wnt/Beta-catenin signaling by 1,25(OH)2D/VDR and calcium/Casr VIT NR1i1 CYP2R1 PTCH1 SHH SMO CYP27A1 CTNNB1 PMC7006399__F6 Gene network analysis and interaction subnetworks CANX GNAT1 GNAT2 GSK3B BRAF PDE6A MTOR RHO PCK1 ITGAV HEL-S-99n G6PC3 PRKCI DLAT HEL-S-68p HEL-S-80p ALDH7A1 ITGB5 CYBB PMC6400144__F2 Regulation of the C-type lectin receptor signalling pathway by curdlan and MacroGard® TH SYK STAT2 IL3 IL27 RELB IL6 MDM2 CCL2 CAP1 CYLD PMC4632638__F2 Ibrutinib: a first in class covalent inhibitor of Bruton’s tyrosine kinase CD79B SYK CD79A BTK BCL10 CARD11 LYN MYD88 PMC5987014__F2 Sclerostin and the Wnt/Beta-catenin signalling pathway SOST APC LRP5 LRP6 CTNNB1 PMC4903900__F1 Epigenetic modulation of gene expression governs the brain’s response to injury YY2 PRC1 SIRT1 PMC7014054__F15 PtNPs change transcriptional networks ATF3 JUN JUND EGR1 STAT2 MAF ATF4 EGR2 TSC22D3 TNF RUNX2 FOS PMC321618__F7 Statins and bacterial infection: model illustrating the effects of statins on S. enterica serovar Typhimurium infection TH PLG RHO PMC1664665__F2 Regulation of the axon cytoskeleton by PI3K signalling CDC42 APC GSK3B RHO PMC1664665__F3 ECM-integrin signalling coordinates with growth factor signalling to regulate efficient axon growth CDC42 HEL-S-28 ARHA PMC3018769__F8 Composite figure from all time points of microarray data showing apoptotic pathways in HepG2 cells when exposed to PCB-153 (70μM) and PCB-77 (70μM) AQP4 BAX JUN TGFB1 CSF2 GPR65 CASP8 AQP3 TXNIP IL13 NFKB2 TWIST2 TNF MYC CYP1A1 FOS BCL2L1 CASP3 AHR BCL2 MT1G TBP TNFSF10 CREB1 PMC7004311__F1 One-carbon metabolism GAA AS3MT HEL-S-20 PEMT PC HEL-S-61p MTR PMC4214059__F1 A causal model specifying how genetic variation increases the susceptibility to clinical disease through smoking and alternate pathways () CHRNA3 CHRNA5 CHRNB4 PMC3344904__F1 High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC5333035__F5 Fibroblast growth factor-4 (FGF4) signal transduction pathway governs trophoblast proliferation and differentiation GMNN CDC2 FGF7A APC PMC3936609__F6 Redox-Mediated and Ionizing-Radiation-Induced Inflammatory Mediators in Prostate Cancer Development and Treatment BAX PMC3936609__F7 Redox-Mediated and Ionizing-Radiation-Induced Inflammatory Mediators in Prostate Cancer Development and Treatment TGFB1 SMAD2 TGFBR3 SMAD4 PMC3515920__F1 Retinoid refractoriness due to phosphorylation of retinoid X receptor alpha (RXR A), and its restoration by acyclic retinoid (ACR) in liver carcinogenesis RXRA CCND1 ACR PMC6274717__F2 IL-6 signal transduction and modes of the IL-6 receptor system SOCS1 STAT3 STAT1 ARID5A SOCS3 PMC6152498__F2 Targeting the cell cycle in breast cancer CDC2 CDK6 APC FGFR1 TTK CDK2 PLK4 MTOR MYC CDK4 PMC3145607__F5 Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in G1-enriched MCF7 cell cultures KRT18 CDH10 IL27RA FGF13 JUN EGR1 PTN BLMH ANGPT2 PHIP FGFR2 GNAS NKX3-1 MYLK PAWR PAQR3 HOXB7 NAB1 RPRM ATF4 PTGER4 PMC12244502__F7 Mechanism by which NEDD4L prevents colorectal cancer liver metastasis MTOR PMC3145607__F6 Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in S-enriched MCF-7 cell cultures UGT1A3 HEL60 JUN INPP5D SH3RF1 E2F7 MAP2 S100P NDUFA11 GNAS BTG3 ATF3 CTNND2 PDZD2 PKP4 FTL MAFF BTG2 GCLC ATXN1 NFE2L2 ARHGAP18 GDF1 PMC3145607__F7 Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in G2/M-enriched MCF-7 cell cultures ANKRD29 COMP TXNIP PGR SH3RF1 CABLES2 AUTS2 MPHOSPH6 COX6A2 SUMO1 PRKCE DNAJB9 HSF1 NPM1 PRKCA MGMT BAX GLYCTK HINT1 DNAJB4 NBN CARD6 SCAPER MEF2D OSBPL6 CNOT1 PDHA1 GSTM1 NFE2L2 DLD APBB2 PMC3120109__F4 Schematic illustrating that AMPH indirectly stimulates dopamine (DA), glutamate (glu) and BDNF (B) release and stimulation of D1 dopamine, glutamate, and TrkB receptors, respectively, in the striatum AMPH RAF1 RGS4 PTEN BDNF PMC4013419__F1 Major components of Sonic hedgehog (Shh) signaling pathway SUFU SHH SMO GLI3 PMC10759521__F9 DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma BAX RBX1 DDB1 FAS CUL4A CDKN1A DCAF13 PMC8745051__F2 ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors CDC2 BAX RAD50 MRE11A BRCA1 H2AX CDK2 PMC8060181__F1 Osteoblast role in the pathogenesis of rheumatoid arthritis BMP3 DKK1 BMP4 BMP2 MSC BMP7 RUNX2 SFRP1 PMC4238355__F7 Model for roles of microRNAs during the reprogramming process TGFBR2 DCN PMC11826472__F2 After PNI, several cellular changes are observed in the spinal cord, the injury site, and target organs GFAP CSF1 TNF PMC5315629__F3 Post-excision Events in Human Nucleotide Excision Repair RAD18 PCNA POLK PMC6881331__F7 Molecular mechanisms of p53 loss of heterozygosity in breast cancer in response to DNA damage HSF1 ERBB2 MTOR PMC3799205__F1 The leptin-induced pathways STAT3 EGR1 SOCS3 GRB2 MTOR PMC11125855__F1 Intracellular DNA sensors involved in the activation of IFN signaling and the NFKB pathway JMJD6 TBK1 MAVS TLR9 IRAK1 IRF3 IRF7 TRAF3 TNF TRAF6 IRAK4 MYD88 HNRNPA2B1 DHX36 DDX41 PMC1986651__F1 Regulation of cell proliferation and cell death by PKCE BAD PDK2 PMC2546905__F4 Predicted targets of miR-100 and miR-101 in the 3′-UTR of members of the mTOR pathway RICTOR MTOR EIF4E PMC11125855__F3 Inhibition of DNA-sensing pathways by KSHV viral proteins RAD50 CGAS MRE11A AIM2 IFI16 IRF3 IRF7 CARD9 PMC3572136__F8 Novel Pancreatic Endocrine Maturation Pathways Identified by Genomic Profiling and Causal Reasoning AURKA STAT3 CCK BRAF SMAD4 NEUROG3 SOCS3 RB1 STAT1 CCND1 TOP2A MAPK1 GAL ING4 NEUROD1 E2F2 TFDP1 KDM5B KNTC2 AREG IL6 ANGPT2 ID1 COL18A1 CDKN1A FGFR3 RET PMC9213050__F7 TLR2-mediated NFKB signaling pathway is involved in PPV1-induced apoptosis in PK-15 cells TIRAP TRAF6 IRAK4 MYD88 PMC3343650__F5 Three major signaling pathways are altered in prostate cancers TES EGF GNRH1 CYP17A1 SHC1 ERBB4 PIK3C2G NR4A3 ERG SKP2 FLNA IRS1 RB1 CDKN2A BIRC5 CDK6 CDKN2C CDKN1B NTRK1 PMC5732761__F8 Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway NOXA1 SRC PMC5431827__F8 Proposed mechanism by which HBV hijacks IFN/JAK/STAT pathway via activating SOCS2 to facilitate immune evasion and viral infection STAT1 STAT2 IFNAR2 IRF9 IFNAR1 SOCS2 JAK1 TYK2 PMC4174315__F7 Mechanistic model depicting the factor association of DDB2 and XPC with ATR and ATM, influencing the DDR pathway in response to UV damage XPA ATR ATM PMC8126717__F2 Escape From Treatment; the Different Faces of Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia BAX BRD4 CXCL12 CD36 IL3 MCL1 FABP4 MYC CD44 FOXM1 MSC BCL2 ATF4 VCAM1 EIF2A CXCR4 PMC7139330__F1 p38 MAPK activation ZAP70 MAP3K7IP1 LCK PMC4064789__F8 The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer EGF PCNA EGFR PMC6685136__F2 Wnt/Beta-cat signaling pathway RNF43 APC LRP5 ZNRF3 LRP6 GPR49 LGR6 PMC5919976__F4 Proposed integrated model of BTN3A1 modifications induced by phosphoantigens and leading to the antigenic activation of VG9VD2 T lymphocytes RHOB PPL PMC10708146__F2 GSDMD-mediated pyroptosis in DCM SIRT3 MED12 CGAS GSDMD NLRP3 TLR4 METTL14 AIM2 IRF3 MYD88 PMC7196244__F6 An illustration of how EVO exerts anticancer activity in osteosarcoma cells through the suppressing Wnt/Beta-catenin signaling pathway CDH2 APC GSK3B CTNNB1 PMC2856263__F6 Signaling pathways activated by DMXAA TBK1 NOD2 IRF3 NOD1 PMC9244849__F4 Disintegrin and metalloproteinase domain 17-epidermal growth factor receptor signaling contributes to oral cancer pain SYK EIF4B BAD RBL2 CD19 RAC1 RHEB TSC2 TSC1 BRCA1 BCR CD37 MEI1 MDM2 PMC6942807__F2 NRF2-mediated pathway of glutathione synthesis SLC3A2 TXN GCLM PRX SLC7A11 HEL-S-64p HEL-75 PMC5493720__F2 Changes in the methylation state of parentally imprinted genes lead to attenuation of GH/INS/IGF signaling in VSELs IGF1 INS IGF2 PMC9647096__F2 Regulatory pathway and possible targets of ferroptosis in HCC SLC3A2 DAZAP1 EGFR FACL4 SLC7A11 GABPB1 QSCN6 FTH1 CISD1 TEAD2 PRDX5 MT1G GSTZ1 ATF4 ABCC5 ALOXE3 PMC6515024__F1 Bone morphogenetic protein (BMP) signaling pathway and inhibition by Noggin SMAD1 DKFZp781O1323 SMAD4 PMC11982459__F3 Hormonal regulation of the UPR by ABA, JA, and SA HEL-S-162eP PMC4675542__F2 Variants of the Coagulation and Inflammation Genes Are Replicably Associated with Myocardial Infarction and Epistatically Interact in Russians IFNG IFNGR2 IFNGR1 PTGIS IDO1 PTGS1 IRF1 PTGS2 PTPN6 MPO PMC7729528__F1 One‐carbon metabolic pathway MTHFD1 TCN2 MTRR MTR PMC3689245__F7 Proposed mechanism for MTX-induced melanosome transport in melanoma RAB27A LCMT1 PMC8554863__F11 CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NFKB/STAT3 signaling pathway STAT3 CXCR5 ATG5 PMC7974894__F7 Identification of Prognosis-related Hub RNA Binding Proteins Function through Regulating Metabolic Processes in Tongue Cancer LEPR HIF1A FOXP3 PFKM SET PMC11649390__F2 Wnt signaling pathways JUN RYK CTNNB1 PMC8523516__F1 Translational Regulation in Hepatocellular Carcinogenesis RHEB TSC2 TSC1 PMC6917511__F2 Flow chart of the RHPCG database LATS1 TF LATS2 NF2 YAP1 SET PMC6664910__F10 Schematic diagram of LIM kinase-dependent inhibition of n-cofilin activity by Reelin DAB1 GSK3B MTOR PMC11682641__F2 BCR signalling and associated pathways network, genetic resistance mechanisms and pathway adaptive resistance mechanisms to targeted therapies in CLL ROR1 SYK CD79A BTK BCL10 IRAK1 BLNK CD19 LYN MYC IRAK4 MYD88 PMC11682641__F3 Detailed overview of chronic lymphocytic leukaemia's genetic landscape in the context of signalling network CD40 BAX SYK SF3B1 FUBP1 MCL1 IRAK1 BLNK TRAF3 IRAK4 MYD88 BTK BCL10 BCL2 ATM LYN BIRC2 TRAF2 NOTCH1 BIRC3 PMC5359278__F1 Schematic diagram showing the mechanism of action of NSAIDs like aspirin in inhibiting the metabolism of arachidonic acid by blockade of the cyclooxygenases (COX) pathway and the prostaglandins (PG) synthase pathway, thus suppressing PGs synthesis LOX COX1 COX2 PMC6472684__F2 Signaling downstream of the IL-2 receptor (IL-2R): (a) Janus kinase-signal transducer and activator of transcription (JAK-STAT) signal transduction SHC1 JAK3 HIF1A SLC7A5 GRB2 JAK1 MYC PMC3853752__F3 Co-expression network of 106 genes associated to the FA metabolism in P AOX1 SP1 HEL-S-44 PMC6562400__F1 Acquisition of cysteine from extracellular cystine through xCT and de novo production of cysteine through the transsulfuration pathway TXN CTH PMC8311004__F1 Necroptosis: A Novel Pathway in Neuroinflammation RIPK3 TRADD MLKL RIPK1 TNF CYLD TRAF2 FADD PMC8531291__F6 Potential functional mechanism of SIRT3 in heat stress-induced BMECs BAX SIRT3 FIS1 OPA1 MFN1 MFN2 PMC5908872__F5 B-cell receptor signaling pathway BCL10 BCR CDS1 HEL-S-11 LYN GRB2 SHE PMC5998365__F1 Folate-mediated one-carbon metabolism DHFR TYMS MTR HEL-S-51e PMC10985914__F2 Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers CYP1B1 CYP1A1 CYP3A4 PMC1609340__F1 Outline of the TLR signalling pathway TBK1 TLR3 TIRAP TLR4 TLR9 TANK IRAK1 IRF3 IRF7 TNF MYD88 PMC8583797__F9 Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor SEMA4D VAV3 ROCK1 ERBB2 IGF1R ARHA IRS1 PMC9168746__F1 Starch metabolism in potato photosynthesizing (leaves) and storage (tubers) organs GIP HTT CP PMC4877629__F3 Genetic networks generated from the differentially expressed genes from adipose tissues VASP ITGA4 CD27 DOCK3 DEF6 CD180 SIGIRR FBLIM1 SH2D2A FANCA ITGAX GCSAM SWAP70 ARHGDIB ITGA1 PAWR ELMO1 HEL110 FGA PMC8234298__F1 Spotlight on Accessory Proteins: RTK-RAS-MAPK Modulators as New Therapeutic Targets RGS14 FRS2 LAT CRKL SPRED3 KSR1 FHL2 IQGAP1 FLOT1 FLOT2 DOK1 SPRY2 ERBIN CBL SPRED1 SHOC2 FHL1 GRB2 GAB2 SPRY1 NCL PMC9564207__F3 Targeting JWA for Cancer Therapy: Functions, Mechanisms and Drug Discovery BAX CDK12 SP1 GC UQCRC2 MMP2 BCL2 IL8RB PMC5593157__F5 The signaling pathway TSC2 TSC1 MTOR PMC6316701__F2 Effect of SUMO on IFN pathways STAT1 SUMO3 IRF3 PMC7125809__F1 IFN signal transduction cascade and defects in this pathway SOCS1 IFNG IFNGR2 IFNGR1 IRF9 IFNAR1 PIAS1 JAK1 TYK2 PMC4778363__F3 Pathway map for paramylon and wax ester metabolism in E.gracilis C2 F2 HEL-S-162eP HEL-S-5 PMC6316701__F1 SUMO cycle RANBP2 TOPORS SENP1 PIAS1 SENP2 SAE1 SENP3 PIAS2 PMC9023181__F4 Molecular Correlates of Early Onset of Diabetic Cardiomyopathy: Possible Therapeutic Targets VDAC3 COX7B SLC25A5 NDUFB2 ALPI JUN NDUFV2 NDUFA6 COX7C TNF NDUFS3 DECR1 PARP1 SDHB COX8A COX7A2 PRKAG1 DDIT3 CALM1 TNNI3 SCO2 CPT2 NDUFA5 PMC2756767__F2 Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer FAS HK2 PMC2756767__F3 Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer HK2 PC IGF1R MTOR PMC8264607__F9 Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFB induced collagen synthesis in cardiac fibroblasts S1PR1 TIMP1 SKI PMC3857727__F3 NMNATs, Evolutionarily Conserved Neuronal Maintenance Factors FKBP5 GSK3B NMNAT2 PMC6281605__F2 Transcriptional landscape of mouse-aged ovaries reveals a unique set of non-coding RNAs associated with physiological and environmental ovarian dysfunctions KLF4 F11R ABRACL BRCA2 MYC FLNA EIF4E MDFI CLINT1 CBFB INSR NFIB TPM3 MUC1 BCL2 KRT7 MDM2 RTKN AHNAK VASN CCND1 ROBO4 PMC11076713__F8 Schematic model: The interferon and interleukin 27-dependent JAK-STAT signaling pathway IL15 CD40 STAT3 CD80 CGAS IL27 IFIT1 JAK3 SOCS3 CCL5 CCL2 ISG20 SLAMF7 STAT1 ZBP1 CD74 MHC2TA TLR4 CCL7 TLR8 TLR7 ISG15 SIGLEC1 AXL STAT2 IRF9 AIM2 IFI16 B2M IL6 TLR3 IDO1 IFNAR2 IFNAR1 IL7 JAK1 HLA-B CCL8 TYK2 HLA-A PMC3857727__F1 NMNATs, Evolutionarily Conserved Neuronal Maintenance Factors NMNAT1 NMNAT2 NMNAT3 PMC6896083__F2 Schematic overview of CD147 associated partner, molecular pathway and microenvironment interaction involved in cancer progression STAT3 ADAM12 SRC PMC7195839__F4 Non-linear reverse-engineering method for inferring genetic regulatory networks GATA2 LMO2 tal-1 GATA1 RUNX1 LDB1 GFI1 NOTCH1 PMC8154043__F1 Metabolic origins of non-photorespiratory CO2 release during photosynthesis: a metabolic flux analysis MAL CIT PMC5072731__F7 Uncovering the Complex Transcriptome Response of Mytilus chilensis against Saxitoxin: Implications of Harmful Algal Blooms on Mussel Populations MAX CD40 CTSK TRAF3 TRAF6 IRAK4 FADD MYD88 PMC5072731__F8 Uncovering the Complex Transcriptome Response of Mytilus chilensis against Saxitoxin: Implications of Harmful Algal Blooms on Mussel Populations MAX BAX CASP3 ATM MYD88 PMC4583193__F1 Targeting the HGF/c-MET Pathway in Hepatocellular Carcinoma CDC42 EGF HGF TGFA EMD GRB2 MTOR RAC1 PMC3001555__F1 Representation of the transduction pathway involved in Cd signaling TF CD2 PC PMC11811070__F1 Pathways to apoptosis BAX FAS TRADD BCL2 TNF TRAF2 FADD PMC11811070__F2 Molecular mechanism of autophagy ATG10 ATG3 ATG12 ULK1 MTOR ATG5 PMC9353186__F7 Flavonoid Group of Smilax glabra Roxb. Regulates the Anti-Tumor Immune Response Through the STAT3/HIF-1 Signaling Pathway IL4 ARG1 PMC3929669__F4 PPARG signaling pathway during high-altitude vs sea-level pregnancy PPARG RAF1 COX2 GRB2 TRAF6 TNF TRAF2 PMC4540190__F8 Schematic diagram outlining the novel molecular targets of CAFG leading to bone anabolic effects in osteogenic cells and fracture healing induced by BMP2/Wnt/Beta-catenin pathway SMAD1 SOST DKK1 BMP2 SMAD4 RUNX2 CTNNB1 PMC6275309__F1 Molecular pathways of the neuro-immune hemostasis model CD59 FH APC PC CD46 CD55 PMC5430761__F9 Pathway showing role of Ror1in promoting tumor-cell growth, ERBB3 ROR1 STAT3 CRK EGFR ROR2 PTEN GRB2 JAK1 PMC10671474__F2 Common mechanisms of secondary endocrine resistance in advanced ER+ breast cancer AURKA NF1 EGFR PTEN MTOR PMC11811070__F3 The main mitophagy pathways PHB2 PINK1 BNIP3 FUNDC1 OPTN BCL2L13 PMC10671474__F1 Current endocrine and targeted treatment of metastatic ER+ breast cancer CDK6 MTOR CDK4 PMC11811070__F4 Pathways involved in necroptosis RIPK3 FAS ZBP1 TRADD MLKL RIPK1 CYLD TRAF2 FADD PMC3154935__F4 Influence of Stochastic Gene Expression on the Cell Survival Rheostat after Traumatic Brain Injury OGA STAT3 EGF BAD SDCBP PXN ARAF CRK STAT1 ANGPT1 MOS ADAM10 CAMK4 GRB2 SRC CXCR4 PMC7195839__F3 Non-linear reverse-engineering method for inferring genetic regulatory networks GATA2 CBFA2T3 LMO2 tal-1 RUNX1 NOTCH1 PMC6908489__F4 ROS contribute to ICAM-1 and PD-L1 induction in salivary gland epithelial cells through a JAK(1/)2/STAT3 pathway IFNG STAT3 JAK1 PMC8003559__F3 Activation of innate immune signaling pathway by lipopolysaccharide (LPS) and tumor necrosis factor (TNF) TRADD TLR4 OTULIN IRAK1 TRAF6 TRAF2 IRAK4 MYD88 PMC8294090__F11 Butorphanol Promotes Macrophage Phenotypic Transition to Inhibit Inflammatory Lung Injury via K Receptors ARG1 IRF7 MYD88 PMC4046121__F5A Differential Transcription of Fathead Minnow Immune-related Genes Following Infection with Frog virus 3, an Emerging Pathogen of Ectothermic Vertebrates NR1i1 SMAD6 NODAL RUNX2 TRAF6 SKI PITX2 HDAC1 FOXH1 MAP3K7IP1 TLX2 GSC GRB2 SMURF2 HOXC8 PMC10741879__F7 Schematic model showing the tumor-progression-promoting interaction between CRC cells and TAMs LAMP2 HEL-S-133P CCL7 MTOR CCL8 CCL2 PMC7071268__F3 Integrated overview of the metabolic changes induced by feeding the OBFR diet FAS FH OGDH BCAT2 PC CS GCK PMC8146703__F6 Alteration in the Cerebrospinal Fluid Lipidome in Parkinson’s Disease: A Post-Mortem Pilot Study FAS SCD PC CS PMC5581678__F2 Entanglement of GSK-3B, Beta-catenin and TGFB1 signaling network to regulate myocardial fibrosis SMAD2 APC SMAD6 SMAD4 CTNNB1 PMC9182416__F2 Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin BAX NOX4 PMC7958144__F1 Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation GCG GLP1R INS SST PMC5819894__F2 Apoptosis pathways BAX CASP9 BAD CASP8 CASP2 MCL1 CASP3 TNF FADD PMC12009697__F2 Activation of MAPK and PI3K/MTOR signaling pathways by oncogenic FGFR2 fusion protein RHEB TSC2 TSC1 FRS2 NF1 PTEN GRB2 PMC10976388__S1 Depiction of Wnt Signaling Dysregulation in TNBC Cells When Compared to Healthy, Noncancerous Cells BCL9 APC FZD7 LRP5 LRP6 CTNNB1 PMC3584002__F7 Model for GPN1, 2, and 3 function in biogenesis of RNA polymerases II and III MBDin GPN3 GPN2 PMC8088470__F3 Role and mechanisms of polycomb repressive complex 2 on the regulation of osteogenic and neurogenic differentiation of stem cells CDC2 SP7 MSC EZH2 IBSP MX1 FHL1 ZBTB16 IRF8 RUNX2 WNT10A CTNNB1 PMC5871976__F1 Moloney-murine leukemia virus (PIM) kinases regulate cancerous pathways MYB BAD GSK3B MDM2 MTOR MYC CXCR4 PMC5871976__F2 Phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mTOR pathway adapted from figure 2 of and figure 1 of RHEB TSC2 TSC1 PTEN PMC5871976__F3 Interrelationship between PIM, AKT and mTOR adapted from figure 2 of TSC2 EIF4B EIF4E PMC7360727__F2 Insulin signaling with highlighted in red pathways found to promote brain insulin resistance in AD and DS APP MTOR IRS1 PMC4267808__F4 The Shared Crosstalk of Multiple Pathways Involved in the Inflammation between Rheumatoid Arthritis and Coronary Artery Disease Based on a Digital Gene Expression Profile ENO1 PMC7360727__F3 Shared alterations between young DS and AD brain GSK3B PTEN MTOR IRS1 PMC5819894__F6 Metabolism pathways FASN TIGAR SCO2 PMC7090099__F3 Integrated analysis of GC-MS and LC-MS profiles GIP DAP PMC6095600__F3 Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes STAT3 TIMP1 SREBF2 IFI35 TNF RB1 IFNG ACSL1 NR1C1 ANGPTL4 CD74 IL18 MAF SP3 MVD DHCR7 ELOVL6 PMC3829153__F8 Molecular mechanism of DSS-induced colitis in murine model HSF2 SUFU PTCH1 NOD2 SHH NUMB SMO PMC3461102__F1 Cell-Intrinsic Innate Immune Control of West Nile Virus Infection TLR3 STAT2 IRF9 IRF3 TLR7 TRAF3 JAK1 TYK2 PMC3033173__F2 LMP1 in promoting survival in PTLD TRADD JAK3 RELB IRAK1 ATF2 PMC5233609__F3 Canonical UPR pathway ELF2 ATF4 TRAF2 PMC7137946__F1 Biosynthesis and metabolic pathway of BH4 TH SPR DHFR PAH PMC8468947__F1 Lactoferrin and Its Potential Impact for the Relief of Pain: A Preclinical Approach TLR4 IL18 IRAK1 IL6 TRAF6 IRAK4 MYD88 PMC6098163__F6 Crosstalk between RAAS and FGF-23 pathways FGFR1 TBP TRPC6 SKI ACE2 FGF23 PMC5740609__F2 Cellular processes altered by colonization by a heterologous symbiont: (A) oxidative stress response; (B) molecular signaling pathways; (C) sugar storage, transport, and signaling; and (D) lipid and protein metabolism and transport GPR161 DGAT1 ABCD2 TACR2 FACL4 NAGS DAGLA ACSL1 GCLC SMO ABCD4 SLC16A10 HEL-S-64p PMC6290060__F3 MAP of “p53 Signaling” pathway in (A) HSAEC and (B) A549 cells treated with 1 μM PG over 24 h TH BAX TOPBP1 JUN FAS PCNA PERP JMY PTEN TIGAR MON2 WT1 PIAS1 CDK2 PIGS SCO2 MDM2 P3H2 TRIM29 PMC1174965__F4 Regulation of lipopolysaccharide (LPS) signaling by suppressor of cytokine signaling 1 (SOCS1) SOCS1 IFNG STAT1 IRF3 TRAF6 MYD88 PMC3814391__F7 DNA end resection ATR RAD51 DNA2 PCNA BLM PMC5282886__F5 Critical factors involved in IGF-IR-mediated EMT process WISP3 MUC1 CTNNB1 PMC5282886__F6 IGF-IR signaling in CSCs-like cells biology STAT3 MTOR PMC3276974__F2 Hypothetical model of LRRK2-mediated regulation of the miRNA pathway LRRK2 MRO EIF4E PMC12055823__F4 TCM ameliorates DKD by modulating mTOR-mediated oxidative stress and nutrient sensing pathways RHEB TSC2 ULK1 MTOR SIRT1 PMC5982769__F1 B cell receptor signaling pathway in mantle cell lymphoma CDC42 CD40 SYK JUN CRAT EGR1 ORAI1 STIM1 CD22 BLNK PTEN CD19 ATF2 MTOR ARHA SHE DOK1 CBL BTK BCL10 BCR LYN DOK3 GRB2 PMC7758250__F1 Immune responses elicited by Plasmodium infection CGAS MAVS NLRP3 PDC TLR9 AIM2 IRF3 IRF7 TLR7 IL1B PMC7349003__F2 Role of lncRNAs in the drug resistance of triple-negative breast cancer (TNBC) ARF6 PTEN RPA1 PMC5282886__F3 IGF signaling regulation in EMT SHH ZEB2 GRB2 CTNNB1 PMC12055823__F2 Oxidative stress and autophagy in diabetic nephropathy RHEB STAT3 TSC2 PINK1 TSC1 FOXO1 ULK1 MTOR SIRT1 PMC7847333__F8 Schematic diagram SOST LRP5 LRP6 CTNNB1 PMC3712008__F3 Hypothetical representation of opposite downstream effects of two signaling pathways on the G1 phase of the cell cycle in a breast tumor-initiating cell JUN ZNF703 PTEN IGF1R CDKN2D GATA3 RB1 CDK6 MAP2K4 CDKN2C MAP3K1 FGFR1 ERBB2 CDK2 CDKN1C CCND1 CDK4 PMC6172484__F4 Gene network analysis of DE genes in the infected group NKD1 CREB3L3 IL17F IF2B1 ATP2B3 IL13 LIF THBS2 GZMA IL17A ATP7B TBX21 LCA5L COL1A1 CAPN13 PLS1 MUC1 ACER3 PMC12055823__F1 Nutrient sensing pathway and autophagy in diabetic nephropathy FOXO1 ULK1 TFEB BNIP3 ATF4 ATG5 SIRT1 PMC8699445__F1 Biomarkers of Central Nervous System Involvement from Epithelial Ovarian Cancer PGP RAD51 BRCA2 ATM PALB2 PMC5817805__F1 The BCR-ABL1 signaling pathways targeted by non ABL-directed inhibitors BCR BCL2 SMO GRB2 MTOR GAB2 SIRT1 PMC3712008__F2 Subnetwork representation of protein interactions based on 78 mutated genes in 602 breast cancers - MED23 NCOR1 ACTN2 PTEN DMD GRIK2 PMC8657692__F9 Evaluating the Effect of Lenvatinib on Sorafenib-Resistant Hepatocellular Carcinoma Cells EGFR FGFR4 MTOR PMC6154333__F2 Possible apoptotic pathway induced by photoactivated ZnPcSmix in monolayer cells 24 h post PDT BAX CASP9 CASP8 CASP6 BAG3 TP53BP2 BCL2L10 CASP3 GADD45A BAK1 TNF BIRC3 PMC7758250__F2 Immune regulators in anti-malaria immunity SOCS1 CD40 TBK1 MAVS TLR9 IRF3 IRF7 TRAF3 CTLA4 TRAF6 MYD88 TIGIT RTP4 BTNL2 TLR3 FOSL1 BTLA TLR7 LAG3 PMC11529444__F2 O-GlcNAcylation cycling and UDP-GlcNAc synthesis OGA OGT PMC3363007__F6 The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection APP IL1B PMC2991480__F5 FC-66 expression of the Ingenuity NFKB Signaling canonical pathway ZAP70 UBE2V1 HEL-S-71 EGF NGF LTA TGFA TIRAP PLCG2 BMP4 BMP2 LCK PMC10950925__F5 Ferroptosis Signaling Pathway TF GLS STEAP3 GPX4 HEL-S-64p PMC11085255__F1 Molecular structure and signaling pathway activation mechanism of Nrf2 KEAP1 RXRA CHD6 PMC11085255__F2 Regulation mechanism based on Nrf2 signal pathway HDAC3 BAX FYN KEAP1 GPX4 PDK2 SIRT1 PMC5966448__F6 Modeling the potential cellular roles of three genes upregulated by AnAc in MCF-7 and MDA-MB-231 cells ACLY PDK4 FOXO1 GPR176 SIRT6 PMC5662584__F4 Proposed mechanisms involved in in vitro anticancer activity of surfactin BAX CDK2 AFM CCNB1 PMC10950925__F2 Visualization of the extrinsic and intrinsic apoptosis pathway BAX FAS MCL1 APAF1 FADD PMC4385866__F2 Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach INCA1 F2 FRK NOA1 NRF PMC1797585__F9 Working model for NS action BAD EGFR PMC6154333__F3 Possible apoptotic pathway induced by photoactivated ZnPcSmix in MCTSs 24 h post PDT BAX BNIP3 PMC138838__F1 Signaling through mammalian and Drosophila Toll-family receptors (TLRs) TLR4 CD14 LBP MYD88 PMC11085255__F3 Effects of natural products targeting Nrf2-related signaling pathway on myocardial ischemia NLRP3 SIRT2 SIRT1 PMC5613237__F4 Galactose metabolism pathway APC GSK3B CDK2 CTNNB1 PMC6127641__F1 Possible cellular mechanisms attributed to oxidative stress in Parkinson’s disease (PD) and possible effects of natural antioxidants on specific pathway ROS1 ATR PINK1 LRRK2 PMC9561951__F2 Cellular autophagy, the compelling roles in hearing function and dysfunction ATG9A GSK3B TFEB BNIP3L FOXG1 PMC5451151__F1 Anoikis signaling pathway in cancer cells FAS SRC PMC3710591__F7 Cellular protective response to MeHg through the Keap1-Nrf2 system KEAP1 MAF PMC8003055__F6 Proposed mitochondrial pathway for apoptosis in HCC cells induced by compound 1 BAD CCND1 CDK4 PMC7773022__F9 Proposed model of LPS/JNK/Sp1 or Nrf1 signaling pathways in regulation of TRIM59 expression SP1 TRIM59 NRF1 PMC4651715__F4 Three major signaling pathways that regulate cell size in normal cells.A PRR5 RHEB TSC2 GSK3B BRAF PTEN MTOR DEPTOR PMC8934427__F2 Interplay Between Coronavirus and Type I IFN Response MAVS STAT2 IRF9 IRF3 HEL-S-11 PMC9327801__F9 Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes HEL-S-62p C2 SI PMC10346248__F11 Schematic models of the NRF2 signaling pathway and its regulatory mechanisms in human skeletal muscle C6 KEAP1 PMC6315839__F2 Model of biosynthesis and signal transduction of jasmonic acid (JA) and ethylene (ET) EBF2 MED25 PMC6199329__F3 miRNA-regulated pathways in preovulatory granulosa cells HEL164 THBS1 MSH2 CDC6 ECT2 RRM2 BRCA2 EZH2 VEGFA FANCD2 FOXM1 NUSAP1 RAD51AP1 AURKB PRC1 CHEK1 MCM3 PMC10145126__F2 PD-L1 regulation by IFNG STAT1 IRF1 JAK1 PMC6199329__F4 Characterization of the miRNA regulators of the human ovulatory cascade PPIE HEL-S-62p LOXL1 NR4A3 TYMS MMP11 FOXM1 TU3A NR3A2 GSE1 HES1 SOX4 GAS7 CRHBP THBS1 MSH2 VEGFA PRIM1 PLXNC1 CD47 ACAN GLCE MFAP2 CHEK1 HERC6 CSPG4 DAAM1 PMC3573791__F1 The metalloproteases meprin A and meprin B: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis EGF FURIN PMC3696550__F6 Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia PIK3CA RAF1 SOS1 VAV2 NFATC2 CARD11 RASGRP3 PIK3CD PIK3R2 GSK3B PIK3R1 CD22 PPP3CA PPP3CC MAPK3 IFNG TEC BCL10 BCR GC MAPK1 FCGR2B CSF2 NCK1 VAV3 APC VAV1 CTLA4 TNF FOS SOS2 PAK1 MAP3K7 GRB2 BIK PIK3R5 LAT PIK3R3 NFKB2 AKT3 PPP3R1 NCK2 NFKBIE CHUK CDK4 CD81 JUN NFATC4 CD19 NFATC1 ARHA KRAS NFKB1 IKBKB NFKBIA NFATC3 NFKBIB CD3E PMC10527328__F1 Exploring the Molecular Landscape of Myelofibrosis, with a Focus on Ras and Mitogen-Activated Protein (MAP) Kinase Signaling MPL HEL-S-99n CBL NF1 BRAF GRB2 PMC9476673__F3 Targeting immunometabolism by active ingredients derived from traditional Chinese medicines for treatment of rheumatoid arthritis ABCG1 OGDH HK2 CS SLC7A5 ABCA1 PMC2634987__F1 The GEP100-Arf6 pathway to invasion EGF EGFR ARF6 PMC12248877__F1 PI3K/Akt/mTOR signaling pathway and the respective inhibitors used in TNBC PTEN MTOR PMC3128624__F6 NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease JUND MAFG MAFF RELA DNAJB14 FOS PMC7368075__F2 AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network PIK3CA PXN GSK3B MARCKS NTRK3 KIF23 FRMD6 SYNPO2 NF1 FGFR1 AHNAK ARHGAP35 TAOK1 MYH10 APC CPEB4 TSC2 PKP4 ARHGEF17 PALLD PLEC SNTB2 NCL RAB10 WASL SGMS2 ATXN2L NEDD9 DOCK9 HSF1 LARP6 LPP LMOD1 EPHB4 RRAGD SDCBP STARD13 ARHGAP31 ARAP1 INPPL1 DENND4C EHD2 SMG1 PIK3C2A FLOT2 DOCK2 TRIM28 OPHN1 STK10 ARHGEF40 LPXN RBM26 SIPA1L1 RALGPS2 CDC42EP2 IWS1 RBM15B SCAF1 SORBS3 TRIO MYO9A PNN DOCK7 AXL RBBP6 TRIP10 NBN CASS4 TUBB DOCK1 SLK HEL114 CRK SSH3 RBM17 ARHGEF7 GRB2 AKAP12 TH ADAR HEL113 SVIL GEM EGFR PHACTR2 ZYX PHACTR4 DPYSL3 RPLP2 DST RPS27 MYLK CLASP1 LIMD1 RIPK2 DENR PEAK1 ARHGEF2 LEO1 TNK2 RPLP0 RANBP1 PTPN1 PCBP1 CORO1C ARHGAP29 ZC3HAV1 NUP153 APBB1IP PRP4K RAB13 SCRIB PMC3439136__F3 Additional analysis of the PPI network RPL37A RPL32 EGFR RPS18 RPL30 RPL6 RP1 RPL3 RPL23A RPS20 MCM7 RPL17 RPL27 RPL9 PMC7375918__F4 Emerging Functions of Lactate in Regulating Signal Transduction and Gene Expression TBK1 MAVS NDRG3 IRF3 VHL PMC3439136__F4 Dynamics in the RTK-Ras-ERK signaling network RPL23A RPL37A RPL37 PMC8484535__F1 Small RNAs: The Essential Regulators in Plant Thermotolerance AGO4 AGO1 ORM2 PMC6498879__F6 Comfrey’s mode of action by interference with the NFKB signaling pathway IRAK1 PTMS TRAF6 IRAK4 MYD88 PMC3439136__F2 TAP-MS PPI RTK-Ras-ERK signaling network RFC4 TCP1 RPL32 EGFR RANBP9 HEL-S-310 RPL30 GAPT HDAC3 RPS27 RPL17 TARP RPL28 RPL27 TBP CCS RPL37A RPL21 RPS18 RPL6 RPL3 RPL15 RPS26 RPL23A RPS20 RPN1 RPL9 CDC37 PMC3875667__F2 Protect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival MSH2 CDK2 PMAIP1 PMC7852227__F7 Schematic diagram DNMT3B TH FOXC1 CTH PMC8863324__F1 Clinical Features and Serum Biomarkers in Identifying Patients with Incomplete Lupus Erythematosus at Higher Risk of Transitioning to Systemic Lupus Erythematosus: Current Perspectives tmp_locus_29 APC PMC7979537__F8 Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling STAT3 SOX2 CHRNA7 PMC3011046__F2 FAS generates an endogenous ligand for PPARA in liver FAS NR1C1 CEPT1 PMC4039369__F1 Yeast pathway map of nucleotide degradation and ribose salvage tal-1 PGM3 HEL-S-49 PMC2921256__F1 Biology of the von Hippel-Lindau/hypoxia-inducible factor (VHL-HIF) axis in the setting of hypoxia or a mutation or aberration of the VHL gene product TGFA EGFR EPO BNIP3 MTOR VHL PMC4930294__F2 Signaling pathways important for stem/progenitor cells regulation RNF4 ATOH1 APC ZNRF3 ADAM10 GPR49 PMC5271588__F6 Cross-talk between apoptotic pathways BAX FADD PMC4345829__F5 MicroRNAs (miRNAs) and autophagy (adapted with permission from Ventham et al, Gastroenterology) ATG16L1 TLR4 IRGM NOD2 PMC1683566__F5 Integration of gene expression with the proposed mechanistic pathway initiated by comfrey treatment leading to tumorigenesis HEL-S-22 EGF UGCG TIMP1 ABCC1 TGFB1 HGF CCR2 MAPK9 ITGAV HMOX1 INHBA CCNE1 CYP7A1 COL4A2 ABCC3 MMP2 APP KRT7 ABCB9 S100A4 NOS2 KRT5 KRT2 LIF PLAUR KRT3 KRT4 GJB1 XPC SPP1 ATF3 GSTA3 IGF1 CDKN1A GSTM3 EDN1 ADRB2 BCL2 TNFSF10 GADD45A PMC6571000__F6 T cell receptor signaling pathway and cytokine-cytokine receptor interaction affect the rehabilitation process after respiratory syncytial virus infection CD3D ZAP70 EGF PYCARD PIK3R3 TNFRSF1A CD22 E2F5 PPP3CC CSF3R IL1R2 IFNGR2 SH2D1A HLA-DRA CSF2RB FYN INHBA NOG IL18 ITGA6 ITK IL18RAP IL1B CD2 IL18R1 VAV3 ITGB7 PLEKHO2 PDGFA CD40LG CARD6 PSTPIP1 ID3 NCR3 ICOS gdf7 IL17RA HLA-DMA CXCR1 IL8RB CD3G SMURF2 IL10RB CARD9 LCK PMC9599362__F3 NFKB Mutations in Germinal Center B-Cell Lymphomas: Relation to NFKB Function in Normal B Cells CD40 SYK CD79B CD79A CARD11 TLR9 IRAK1 MTOR TRAF6 IRAK4 MYD88 BCL10 BCR PMC11786704__F6 Schematic illustrates the signaling pathways involved in wound repair BAX GCG JUN COX2 PC GCGR PMC9599362__F1 NFKB Mutations in Germinal Center B-Cell Lymphomas: Relation to NFKB Function in Normal B Cells LTBR BCR RELA RELB PMC10454712__F2 Diagram of genes and metabolite pathways associated with the major secondary metabolites of tea plants APRT GCG GC PMC7866651__F8 Diagram of regulated pathway in liver of GIFT exposed to acute hypoxia stress after 96 h TG INSR HEL-S-278 HEL-S-102 MB ELOVL6 INS PMC6078353__F4 KEGG pathway functional analysis of differentially expressed genes CRK BAD VASP HEL-S-28 PTEN ARHA DOCK1 PMC4890891__F3 Regulatory network of Katanin protein NEDD8 DYRK2 LECT2 SKP1 PMC7856673__F1 Current model of LOX-1-dependent signal transduction ROCK2 ARHGEF1 CXCL2 VCAM1 ARHA SRC PMC5042386__F1 Schematic overview of the Hippo signaling pathway LATS1 MOB1A TEAD2 TEAD3 TEAD4 PMC5042386__F2 Regulation of the Hippo signaling pathway in mammalian cells LATS1 LATS2 TEAD2 PATJ TEAD3 AMOT APC MPDZ RHO NF2 TEAD4 CTNNB1 PMC5390871__F9 Lysophosphatidic acid‐induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1 LPA PC HEL-S-11 PMC6548759__F3 Results of Pancancer Pathway Panel analysis LTBP1 THBS1 SP1 SMAD4 NODAL ARHA PITX2 TGFBR1 BAMBI IFNG RBX1 E2F4 FST SKP1 PMC3032410__F7 Dynamic Distribution of CARD11 at the Immunological Synapse is Regulated by the Inhibitory Kinesin GAKIN CARD11 APC TRAF6 PMC4212018__F1 Adaptive resistance to RAF inhibitors in melanoma ERBB3 EGFR BRAF NRAS ERBB2 GRB2 PMC9130585__F2 Pathophysiology of Primary Cilia: Signaling and Proteostasis Regulation NR1H4 CEP290 PCM1 SUFU EGFR PTCH1 MYH9 OFD1 CEP131 BBS4 SHH IFT27 PMC7166181__F3 Signaling Pathways Regulated by PI3K/Akt/mTOR that Promote Neuritogenesis: A variety of ligands lead to neurite initiation and elongation through PI3K/Akt/mTOR signaling CDC42 ATF3 NGF RICTOR HGF ROCK1 APC GSK3B MAP2 MTOR BDNF RAC1 PMC7382367__F3 Role of methyltransferase-like enzyme 3 and methyltransferase-like enzyme 14 in urological cancers ITGB1 METTL3 CCND1 LEF1 CTNNB1 PMC7407959__F1 Surgery and temporal sequence of icv CA3 HEL-S-11 PMC4156265__F5 Pathway analysis LTB PGC LOX PMC3118704__F3 Toll-like receptor-4 (TLR-4) signaling via MyD-88-dependent pathways EGR1 TLR4 CD14 TRAF6 LBP MYD88 PMC6663492__F1 Pathways that may impact radiosensitivity EGFR PTEN MTOR PMC3367558__F1 Wnt signaling pathways MAP1B DKK1 APC GSK3B ARHA RAC1 CTNNB1 PMC6528674__F3 Non-canonical Hippo signaling in the regulation of leukocyte function STAT3 RAB13 DENND1C IL17A FOXP3 PMC3367558__F2 Wnt signaling at vertebrate neuromuscular junctions MUSK PAK1 APC WNT3 RHO RAC1 CTNNB1 PMC10992393__F1 De novo synthesis of nervonic acid and optimization of metabolic regulation by Yarrowia lipolytica TES FAS HDC CIT PMC6528674__F4 Non-canonical Hippo signaling in the regulation of leukocyte function RAB27A TLR1 TLR4 MYD88 PMC3367558__F3 Negative regulation of AChR clustering by Wnt3a WNT3A GSK3B CTNNB1 PMC4001841__F1 PI3K-AKT pathway and associated cellular activities BAD PI3 GSK3B MDM2 SRC CTNNB1 EIF4E PMC3772101__F1 Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway STAT1 STAT2 MED14 IRF9 ISG15 PMC9368934__F2 Stem Cell-Based Therapies for Inflammatory Bowel Disease KEAP1 MAF MPO PMC9693551__F1 Modulatory Effect of Chlorogenic Acid and Coffee Extracts on Wnt/Beta-Catenin Pathway in Colorectal Cancer Cells CD44 CGA EGFR APC GC GSK3B GPR49 CCND1 CTNNB1 PMC6528674__F1 Non-canonical Hippo signaling in the regulation of leukocyte function LATS1 LATS2 PMC7927447__F2 Action of targeted therapies in PIRDs APC PTEN PMC5079521__F1 Physiological mechanisms and therapeutic potential of bone mechanosensing PKD1 RUNX2 PMC5672004__F8 Pathways summary showing identified kinases in BTV infected cells BAD PLK3 EEF1A1 PMC5313049__F9 Genome evolution in the allotetraploid frog Xenopus laevis HEL-S-31 CDC20 UBE2C COX7C CDKN2D CDKN2B PLK1 CCNH CCNB3 CTNNB1 MOB1A MOBKL1A LATS2 CRB2 CDKN2C CCND2 NF2 TEF CDC2 CEND1 APC FAM50A YAP1 CAPZA1 CRB3 AURKB CDKN1B SCRIB CDC25B TNLG7C PMC2387053__F2 Aging of the brain, neurotrophin signaling, and Alzheimer’s disease: is IGF1-R the common culprit? IGF1 PTEN IGF1R PMC4055761__F3 Chromatin Remodelling Induced by the Freshwater Cyanotoxin Cylindrospermopsin in Human Intestinal Caco-2 Cells KRT18 MTMR3 UBE2W EVI1 SMN1 CCNL2 MDM4 MEAF6 SLMAP BTG1 PNO1 RNF114 HELZ DUSP16 EPC1 BAT2L SPAG7 MED6 MED10 RNASEL EXOSC8 LRRC47 ELP4 MED21 POLR3E FHOD1 MTF1 PPP2R1B UHRF1 DDX3X PMC8527892__F2 Plasmin Cascade Mediates Thrombotic Events in SARS-CoV-2 Infection via Complement and Platelet-Activating Systems CXCL5 NRP1 SOCS3 IL6R CXCL3 CD109 MAP3K8 STAT1 INHBA CTDSPL PROS1 SAA1 S100A7 IFNGR1 RHOF VAV3 FLNB IRF9 IRF7 OAS3 KRT4 ITGB3 KRT6B HBEGF ADRB2 PRSS23 SERPINB2 CYP4F3 TCN1 CCL20 CTSH BCL2A1 SPRR2E CXCL1 TNFRSF10A ALOX15B PARP12 POU2F2 IFITM3 MX2 PPARGC1A MX1 OAS1 OAS2 OTUB2 DTX3L ANXA1 XAF1 CXCL6 HCAR3 NFKBIA VNN1 EPHA2 NCF2 TUBB4B SPARC IRAK2 TRAF3 CSTB SERPINB8 P2RY6 ADAM8 TIMP3 CSF2 SLPI PLAUR IFITM1 G0S2 RHOV IVL KRT75 SPRR2D KRT24 LTB TNFSF14 FOXO1 SPRR2A TNC LY6D TNFAIP3 UBE2L6 HEL-S-62p IFIT1 IKBKE IFIT3 TUBA1B CSF3 GBP5 HELZ2 PLAT TGM1 CDA TUBA4A IFI44 LDLR RND1 TYMP BIRC3 TUBA1A B4GALT1 LIF CXCL16 BLNK CXCL2 EPHA4 IL6 KRT23 PTGS2 TUBA1C PMC4590607__F3 Functional architecture of AXAN GABARAP GABARAPL1 DDOST CAB39 STIM1 PRKAA1 TP53INP2 ATG3 CAMKK2 SRM AGL ECHS1 RAB24 LYST EIF3A USE1 MAP1LC3C ATG16L2 RPN2 ATG12 ATP2C1 PRKAG3 SAFB GOSR1 PRKAB1 GABARAPL2 RPL35 STK11 ULK1 EDEM1 PRKAG2 SAFB2 RHO MTOR GDA STRADA VPS33B FARSB RB1CC1 VPS18 ATG5 ULK2 VPS16 RPTOR VPS33A ATG16L1 CKAP4 ATG10 RPL13A GYS1 PRKAA2 MAP1LC3B2 VPS39 ASNS AKTIP PMC6373340__F5 Insulin resistance mechanism and potential sites of vanadium activity FAS CD36 PTEN CS RHEB LPA TSC2 TSC1 F2 PC GRB2 ELOVL6 PKLR UNK PMC7756379__F5 Proposed pathway for gladiostatin biosynthesis AMT REL PMC5584733__F3 Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms IPP RCE1 RAC1 PMC7174042__F1 Primary motor neuron components and lipidome pathways in MND/HSP PTDSS2 PTDSS1 HSD3B7 PCYT2 PISD DDHD1 ETNK1 PNPLA6 CYP7A1 CYP11A1 CH25H PC CYP46A1 CYP7B1 CYP3A4 CHKA CYP27A1 PMC7174042__F2 PE and oxysterol pathways and the mitochondria-associated ER membrane (MAM) PTDSS2 TRIAP1 PTDSS1 PCYT2 PISD VAPB PNPLA6 SIGMAR1 REEP1 MFN2 CYP2U1 PC CYP7B1 CHKA CYP27A1 PMC9104818__F5 Bone Progenitors Pull the Strings on the Early Metabolic Rewiring Occurring in Prostate Cancer Cells STYX TMEM30A RASSF2 RAN TGFBI ADAMTS4 DLGAP2 SHC1 SMAD2 SPARC DBT EPO MRC2 SDC4 SMAD4 NFIL3 TTYH3 HERC2 AHSG POSTN NGF MOAP1 HSPD1 FAM20C SHANK1 TNFAIP2 PIM3 OTUD5 PLOD3 ZC3H11A CTGF TRAM2 EPHX2 NR1i1 HEL-S-2 SRI VAV3 HK2 SPG11 TNFSF13 BNIP3L VEGFA SORCS2 TPP1 PITPNM2 SYNGAP1 PTBP1 TMEM184A UXS1 ECM2 ESPN NARS1 PLEKHG2 RALGAPA2 TUBG2 PCNX3 RPP40 EHHADH IFFO1 COMP KBTBD11 CCPG1 CD36 HEL-S-62p CPNE1 C4A INS GPX1 SGPP1 CHUK ATF4 MX1 KDM3B CFL2 KIRREL3 SEMA4C PTPRN ITGAM NR1C1 CLP1 CXXC4 RUNX1 CACNA2D1 CREBBP DEPDC5 XDH SLC36A1 SLC24A3 PMC8961331__F3 Interplay Between TGFB Signaling and Cell Metabolism SGMS1 SPHK1 PMC9658815__F6 Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications NQO1 TNF PMC8961331__F4 Interplay Between TGFB Signaling and Cell Metabolism AMD1 ARG1 PMC9658815__F5 Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications POMC TYRP1 PMC9658815__F2 Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications SMAD2 SMAD4 PMC4360697__F2 Underlying link between Alzheimer’s disease and type 2 diabetes mellitus.Notes: Insulin resistance reduces the degradation of AB by IDE, and makes the combination of insulin and insulin receptor impaired IDE BACE1 GSK3B APP PMC5507898__F8 Hypothetical model for the role of ASXL1 in cell cycle progression through the cooperation with AKT1 and EZH2 ASXL1 CDK2 EZH2 PMC9696306__F6 Screening for Hyperthermophilic Electrotrophs for the Microbial Electrosynthesis of Organic Compounds FH MME HBD AACS MTR PMC5846498__F2 Novel bacterial ADP-ribosylating toxins: structure and function EGF HBEGF PMC7607069__F14 PPI network of TP53 signaling pathway genes (GeneMANIA) TP73 THAP10 CUL9 RPL11 NPAS3 CDKN2AIP RBBP6 PEX19 ELL MDC1 TP53BP1 RPL5 MDM4 WWOX UBE2A MDM2 SMURF2 PMC3521201__F1 Central carbon metabolism pathways in E HPR GALP CIT PMC4276873__F7 Tpl2-ERK activation during TLR signaling SYK TIRAP TLR3 TLR4 TLR9 CD14 TLR7 MYD88 PMC7589016__F2 Intracellular signaling cascades activated by interaction of BDNF isoforms with its receptors PTEN ARHA TRAF6 PMC11684189__F1 Cholesterol metabolic pathway LPL TG ABCG8 ABCG5 HMGCR ABCB11 NPC1L1 CYP7A1 LDLR ABCA1 PMC8609078__F6 CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway CD200 GRB2 JAK1 PMC3917357__F1 Functional properties of ion channels and transporters in tumour vascularization TEC PMC8173049__F7 Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes RIPK3 GSDMD NLRP3 TIRAP TLR4 RIPK1 TNF LBP IL1B MYD88 PMC3640917__F4 Pathway for Death receptor signalling at 24 h post-M TBK1 TRADD TRAF2 DIABLO FADD PMC7982480__F1 Neuroprotective effects of ghrelin in PD UCP2 BAX WNT3A WNT1 IL1B CTNNB1 PMC4739739__F3 Connectivity of differentially expressed genes in the important signaling pathway following mixed PCBs exposure in human PBMC in vitro depicting the connectivity between genes expressed (with ≥1.5 fold change, t-test, p <0.05) SACS SUZ12 EED ALPL KEAP1 AGAP2 MAPK9 MYT1 CCNA2 GNAS RGS7 BCR VPS37B DHPS TRIB2 VPS37A AXL RBMS1 TK1 IFNAR2 MYCBP2 STX4A PGRMC1 NFYC GRB2 LMNA CP TES SNAP23 STK11 GLS ING3 NFKB2 VPS37C RELB EMP3 PHKA2 ATP2A2 UHMK1 VPS28 RBBP7 GNB1 YWHAQ GUK1 WTAP ZNF217 GABPA HBB TNPO2 SRSF9 JUP PARP10 PKP2 HTATIP2 DPP3 MEF2D RPL15 PRKDC CYP11A1 RELA MORC2 MAP2K2 PMC10855599__F2 JAK-STAT signaling pathway and PI3K-AKT signaling pathway that affect AD STAT3 IL13RA1 JAK1 TYK2 IRS1 PMC2796182__F4 Regulation of nitric oxide signaling by thrombospondin-1: implications for anti-angiogenic therapies LPA FYN CD36 SRC CD47 FGF2 PMC6755424__F7 TGF-ß signaling pathway BAMBI IFNG RBX1 THBS1 FST SMAD4 SKP1 NODAL ARHA TNF TGFBR1 PMC2745153__F2 Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling STAT3 EGF HEL-S-28 RHO PMC5697091__F10 List of genes involved in the complement and coagulation cascades pathway generated by KEGG of the differently expressed genes between C VWF C6 C7 CPB2 HEL-S-62p CR2 F11 CS TFPI F2 F10 F3 C9 A2M F8 PMC6048758__F4 Regulation of SREBP1 and lipid metabolism by oncogenic signaling ACLY CDC2 EGF EGFR FASN FGFR3 KRAS PMC8910032__F6 Senescent CD4+CD28− T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis ZAP70 STAT3 MAP3K7IP1 PMC7672342__F3 Tuberous sclerosis: a review of the past, present, and future RHEB MLST8 TSC2 TSC1 TBC1D7 DEPTOR PMC5473728__F1 Schematic Overview of the Norrin-Beta-Catenin PathwayMutations in the genes encoding the ligand Norrin, the receptors FZD4, LRP5, and TSPAN12, and now the transcriptional activator Beta-catenin all cause FEVR FZD4 APC TSPAN12 LRP5 PMC5614322__F2 Hypothetic pathogenesis of OPLL SOX9 MSC RUNX2 PMC6134417__F1 抗表皮生长因子受体和抗血管内皮生长因子药物在非小细胞肺癌治疗中的作用 EGFR IGF1R MTOR PMC3296959__F2 Innate immunity and the ubiquitin–proteasome system in PD LRRK2 ATM ISG15 PMC8210559__F5 HOXA5 confers tamoxifen resistance via the PI3K/AKT signaling pathway in ER-positive breast cancer CDH2 SUZ12 EED SOX2 EZH2 HOXA5 PMC2849832__F1 IFNG signaling through the JAK/STAT1 pathway IFNG STAT1 IFNGR2 IFNGR1 CDKN1A PSMB8 IRF2 IRF1 JAK1 PMC8910032__F3 Senescent CD4+CD28− T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis BAX CDK6 H2AX ATM CDK4 PMC7369353__F1 Main mechanisms of Wnt/Beta-catenin and PI3K/AKT/mTORC1 pathway interconnections TSC2 APC GSK3B AXIN1 LRP5 LRP6 TCF4 DEPTOR CCND1 AXIN2 EIF4E PMC3750403__F3 BIOBASE-derived signaling network centered on p38 MAPK TF FOXO3A TLR4 PHC2 FECH MYC CREB1 PMC9105968__F5 Lactoferrin as a Human Genome “Guardian”—An Overall Point of View CDC2 CDK6 CDK2 MTOR CDK4 PMC6390476__F1 Schematic overview depicting regulatory pathways for PYY and GLP-1 secretion by enteroendocrine L-cell FFAR3 PYY GPR119 FFAR2 FFAR1 PMC3480485__F5 Forkhead Box M1 (FoxM1) Gene Is a New STAT3 Transcriptional Factor Target and Is Essential for Proliferation, Survival and DNA Repair of K562 Cell Line BARD1 IFNG MSH6 ATR RAD1 ATM ATF1 BLM PMC9319477__F6 Cyclic Hypoxia Induces Transcriptomic Changes in Mast Cells Leading to a Hyperresponsive Phenotype after FcERI Cross-Linking MAP2K6 FCER1G PMC6351700__F2 Signaling model in a cell during tumor formation RHEB TSC2 OAF MTOR PMC6351700__F3 Schematic/proposed signaling model of role and regulation of claudins in a cell during invasive or metastatic stage RHEB TSC1 EGFR APC LRP5 LRP6 MTOR SRC TNF PMC9236612__F8 Growth arrest and TRIM37 growth arrest activity ANKRD26 TRIM37 PLK4 CNTROB PMC11088339__F5 Therapeutic application of adipose-derived stromal vascular fraction in myocardial infarction SMAD2 CCR2 MTOR TRAF6 CCL2 PMC7537941__F2 Activation of the coagulation cascade and endogenous anticoagulants TF TFPI APC PLG TNF PMC11088339__F2 The transforming growth factor B (TGFB) signaling pathway in cardiac fibrosisTGFB regulate phenotypes of the cells through activation of mothers against decapentaplegic (SMAD)-related pathway together with p38 pathway SMAD2 SMAD4 PMC4000463__F1 JAK2 receptor signaling and activation of STAT pathway STAT3 MPL EPO PMC5478092__F5 Metallothionein roles in aging and reactive oxygen species ATF7 PMC8398928__F1 Current Therapies in Clinical Trials of Parkinson’s Disease: A 2021 Update PINK1 LRRK2 HEL-117 PMC6879750__F5 Conserved and novel homologues of bilaterian genes involved in axis patterning and regulated by the Wnt/Beta-catenin signalling pathway in Hydra FOXB1 SOX30 GSK3B ERG VSX2 IRX6 RUNX2 DMRT3 ARX OTP GATA3 TLX1 CTNNB1 LMX1B DLX1 NKX2-1 LEF1 PMC3636756__F1 Two kinases are required to promote mitotic entry CDC2 WEE1 MYT1 PMC11597433__F4 Wnt signaling pathway [04310] MCC APC LRP5 SMAD4 LRP6 BAMBI CCAR2 SOST RNF43 NOTUM CER1 NLK SIRT1 PMC6944532__F3 Representative Examples of Gain-of-Function (GOF) Mutations That Perturb Signaling Pathways CACNA1H TERT IRS1 PMC7198026__F2 Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges STAT3 PIM1 BCL2 SRC PMC5591914__F5 5-HT2A receptor antagonist contributing to DM-induced cardiovascular complications VCAM1 RHO PMC3636756__F2 Two hypotheses for Gwl activation and mitotic entry ARPP19 WEE1 MYT1 PMC3636756__F3 CSF arrest is the result of a tight balance between PP2A-B55 and PP2A-B56 CDC2 ARPP19 APC PMC5591914__F1 5-HT biosynthesis and metabolism in peripheral tissues TPH1 PC TPH2 PMC2671376__F7 Signaling in the PI3K/Akt pathway and deregulations detected in GRMD skeletal muscle IDE PTEN MTOR PMC10850268__F1 Signaling pathway of insulin action and the selective impairment of insulin receptor substrate (IRS)-protein kinase B (Akt) signaling pathway in insulin resistance CD36 FOXO1 PDPK1 MTOR IRS1 PMC7154126__F1 Interplay of glycolysis pathway with EMT factors HGF HK3 HK2 ENO1 HEL-S-87p PMC3046639__F1 RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it HRAS CBL RAF1 SPRED1 SOS1 NF1 SHOC2 BRAF CS GRB2 KRAS PMC7830359__F1 Network of differentially expressed genes prior to initiation of anti-TNF therapy based on interactions using Ingenuity Pathway Analysis HK2 IFITM3 OASL EPSTI1 MAP2K1 MAP2 KLRD1 HLA-C GNLY PMC6467501__F1 Xs and Y of immune responses to viral vaccines IL15 HEL-S-2 IFI6 IVNS1ABP CREBZF XCL1 AIM2 TRIM2 IRF7 ISG20 CD44 TRIM25 ATM MX1 TLR7 ISG15 SRC HLA-A OAS2 ADA PMC7093136__F5 Summary of signaling pathways and molecular events induced by Chlamydia to promote inclusion development and EMT induction, leading to complications TAC3 EGFR TGFBR3 SMAD4 PMC8144171__F4 Functions and Targets of miR-335 in Cancer LATS1 RHEB TSC2 LATS2 TSC1 PTCH1 SHH SMO MTOR GLI3 PMC2993607__F1 RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer? BMI1 CDC2 CDK6 CDC6 MYC CDK4 CTNNB1 PMC5372562__F2 Interaction and localization of proteins belonging to the integrin signaling pathway and found in samples 2 and/or 3 PXN ARF1 ARF6 GSK3B MAPK8 MAPK3 RALA NRAS MAPK1 RHOF NCK1 CRKL HEL114 HRAS ACTR2 ACTR3 RAP1A PFN2 GRB2 CDC42 ARPC4 VASP ARHG ARPC2 ARPC3 WASL ZYX PAK4 BRAF RAP2B RAC3 MYLK ACTA2 PLCG1 RALB TTN ATM TLN1 PFN1 PARVA TLN2 ARHA KRAS RAC1 RHOT2 RHOB ARF4 RRAS RRAS2 PS1TP5BP1 PMC5372562__F3 Interaction and localization of proteins, belonging to the angiopoietin signaling pathway and found in samples 2 and/or 3 NCK1 PAK1IP1 NFKB2 PIK3R2 PAK4 PTPN11 KRAS IKBKG HRAS BIRC5 PIK3R4 NFKB1 IKBKB CHUK ATM RRAS GRB2 RRAS2 PMC7581770__F1A Systems analysis of avascular necrosis of femoral head using integrative data analysis and literature mining delineates pathways associated with disease APRT TF VEGFC ANXA2 CR2 TGFBR3 MMP9 VEGFA MAP2 TGFBR2 BMP6 MMP2 APOB TNFSF11 KDR PMC7472741__F2 SREBP-regulated mevalonate pathway and its regulation REST IPP EBP SQLE SC5D PMVK LDLR DHCR7 ARHA HSD17B7 TM7SF2 MVK PMC9586216__F1 Protein arginine methyltransferase 5 regulates SHH-subgroup medulloblastoma progression SUFU SHH SMO PMC7504523__F5 IFN signaling pathway suppressed by ADAR1 via the miR-302/367 cluster MAVS IRF9 IFNAR1 IRF3 IRF7 JAK1 TYK2 PMC8958723__F3 In silico Prediction on the PI3K/AKT/mTOR Pathway of the Antiproliferative Effect of O. joconostle in Breast Cancer Models RHEB BAX TSC2 BAD RICTOR CBL PTEN GRB2 MTOR GAB2 IRS1 PMC2730524__F3 Translating insights from the cancer genome into clinical practice BRCA1 EGFR ERBB2 PTEN MYC PMC4939383__F1 NOD1 and NOD2: New Functions Linking Endoplasmic Reticulum Stress and Inflammation ATG16L1 NOD2 NOD1 XBP1 TRAF2 PMC2812679__F8 TK-mediated signaling pathway promoting HaCaT keratinocyte migration EGF HBEGF SRC PMC8897153__F1 Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma HEL107 PGAM1 HMGB1 RPIA PHGDH HEL-S-68p HK2 HEL-S-162eP FBP1 PC ENO1 HEL-S-87p PMC5405564__F6 Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions TF LOXL2 HSPG2 CCT8 HEL-S-62p PLEC FASN DYNC1H1 LAMA3 PMC5449464__F4 Signaling and crosstalk associated with relaxin activation of its receptor RXFP1 GC PMC7456455__F1 Monocytes represent a window between bone marrow and tissues CSF3R CD40 IFNG CD14 CSF1R PMC7422850__F4 Anti apoptotic effect of curcumin BAX FADD PMC12255454__F6 The sphingolipid metabolic pathway and biochemical tools for its investigation CERS3 CERS5 DGAT1 ORMDL1 ACER1 CERS1 CERS2 KDSR FADS3 ORMDL2 SPTLC2 ORMDL3 DGAT2 SPTLC1 ACER3 PMC12255454__F7 Metabolic building blocks within the sphingolipid pathway and their subcellular localization CERS3 CERS5 CERT1 GLTPD1 ACER1 CERK CERS1 CERS2 ACER3 PMC12255454__F8 Pathway map for individual molecular subspecies of sphingolipids beginning from production of the sphingoid base backbone through subsequent metabolic steps, emphasizing key branchpoints (nodes) CERS3 FIG4 CERS2 HEL-S-5 CER1 NODAL PMC4151463__F9 Function of integrin linked-kinase (ILK) in normal and activated stellate cells–implications for fibrogenesis in wound healing CDC42 HEL-S-28 RHO PMC5824489__F3 Sirtuins in Antioxidant and Redox Signaling HCRTR2 SIRT3 SIRT7 NOLC1 AACS NEGR1 SIRT2 SIRT1 SIRT6 PMC11316721__F2 Molecular mechanisms of RBP4 in pancreatic Beta-cell function STAT1 RBP4 PMC8470622__F3 Epidermal Growth Factor Receptor Expression in the Corneal Epithelium EGF HBEGF TGFA BTC PMC7186717__F2 Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment CD80 PMC9131283__F8 5-HT2B-mediated serotonin activation in enterocytes suppresses colitis-associated cancer initiation and promotes cancer progression STAT3 SMAD2 SMAD4 PMC3735202__F3 Schematic diagram showing the Ras signalling pathway and its linkage to the GTPase cellular motility axis (Reproduced with permission from) EGF BAD RHOB PMC8076293__F3 NFKB signalling cascade CGAS MAVS RELA RELB TRAF3 REL TRAF2 PMC7003279__F5 Genes of differential proteins in the interaction network TF RAF1 CD46 ABCA1 CR1 LPA TFRC NME2 SEMG2 APOH SEMG1 LDLR ABCB1 APOC3 HMFT1766 PGP UMOD APOE NPNT PDGFRL CD55 KRAS HRAS APOA2 CHGB RAP1A APOB HFE PSAP YWHAZ PMC7016816__F1 Schematic view of the ferroptosis pathway SLC3A2 TFRC GPX4 FACL4 SLC7A11 HEL-S-64p PMC10030510__F2 Metabolic regulation of dendritic cell activation and immune function during inflammation HEL-S-133P HK2 FASN MPC1 CPT1A PMC6617704__F7 Illustration of IPO5 involvement in CRC BAX CDK6 IPO5 BCL2 CCND1 CDK4 PMC9023807__F3 MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer PIK3CA RAF1 GSK3B PTEN PMC11316721__F1 Molecular mechanisms of RBP4 in insulin resistance TLR4 IRS1 MYD88 PMC9023807__F1 MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer CDH2 CTNNB1 PMC10030510__F4 Metabolic regulation of dendritic cell activation and immune function during inflammation TBK1 FAS HK2 MTOR PMC9023807__F2 MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer TGFBR1 PMC5409774__F5 Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) BAX NGF BAD FAS TRADD IL3 ATM HEL-S-11 APAF1 TRAF2 FADD MYD88 PMC5409774__F6 Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) DCT TYRP1 CTNNB1 PMC5409774__F7 Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) CD40 TIRAP CTSK TLR9 CD14 CPO IRF3 TRAF6 IRAK4 RAC1 TLR3 LBP FADD PMC5031334__F6 Proposed biosynthetic pathway for ATM ART1 ARTN PC ACR PMC2756538__F3 A model for the role of eEF-2K in the induction of autophagy during amino acid starvation and ER stress EEF2K EEF2 EIF2A PMC5661117__F8 Hippo pathway in mesothelioma cells LATS1 LATS2 RHO NF2 AREG PMC3328790__F1 TGFB signaling pathway and its integration with other major pathways that is likely to be involved in the pathogenesis of cardiovascular diseases in elderly patients TGFBR2 SMAD2 TGFBR3 SMAD4 RUNX2 TGFBR1 PMC5508596__F1 Wnt signaling pathways.(A) The canonical pathway is activated once Wnt binds to the frizzled (FZD) receptor and LRP-5/6 co-receptor, thus recruiting disheveled (DVL) protein that inhibits the Beta-catenin destruction complex JUN APC LRP5 LRP6 RYK RHO CTNNB1 PMC4937870__F6 Activation of IL-8 and cyclin D1: proposed POP mixture pathway shared by inflammation and cancer AHR CREB1 CCND1 PMC4855182__F6 Ginsenoside Rg1 promotes osteogenic differentiation of rBMSCs and healing of rat tibial fractures through regulation of GR-dependent BMP-2/SMAD signaling BMP2 MSC RUNX2 PMC7676939__F3 Androgen effects on the adrenergic system in the airway smooth muscle (ASM) KY PMC4224073__F1 Complement system: an overview CRP C6 C7 HEL-S-62p C2 C1S C1R C9 PLG C4A C4B_2 PMC4069674__F1 Suppression of metastasis by mirtazapine via restoration of the Lin-7C/Beta-catenin pathway in human cancer cells APBA1 LIN7C DLG4 CASK CTNNB1 PMC3460211__F3 Formaldehyde-responsive miRNAs predicted to modulate MAM-associated genes in the brains of Mgmt−/− mice NTS RFC1 TXNIP CAMK2D GNPDA2 EPHA4 PMC8815368__F3 BIRC5 was significantly enriched in the apoptosis pathway BAD CAD CASP12 CASP3 ATM APP FADD PMC4935424__F4 Differentially expressed genes in BA, JA and UA groups mapped on the TNFR signaling pathway (1 denotes JA, 2 denotes UA, and 3 denotes BA) HTRA2 BAX TRADD MAP4K2 FADD PMC2996105__F7 Interaction of p75NTR and TrkB signaling BAX BAD PTEN GRB2 PMC8156939__F2 PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders TSC2 BAD TSC1 IGF1 PTEN MDM2 AGA MYC IRS1 PMC2964746__F4 Selected signal transduction pathways that affect AS of transcripts of genes important in cancer FAS SRPK1 PMC3209384__F8 Schematic showing the mechanism(s) of activation of the NLRP3 inflammasome and NFKB signaling pathways by vMyxM013-KO virus infection in human monocytic cell line THP-1 NLRP3 TNF IL1B PMC6317881__F6 Interactions of genes involved in tumor progression and EMT CDH2 HEL113 TIMP1 FUT4 PCNA PDLIM2 MMP17 CTSZ GJB2 ACAN HEL-S-162eP CASP3 BCL2 ACP5 PMC9111413__F2 Non‐steroidal anti‐inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses: EAACI task force on eicosanoids consensus report in times of COVID‐19 IL25 TSLP IL33 IL5RA PMC10650444__F8 Compound 6b for promoting apoptosis of HepG2 cells BAX NSD2 MDM2 PMC4480161__F1 Cross-species comparison of PCD factors implicated in aging HTRA2 FIS1 AIF1 PMC9171412__F3 DNA damage initiates inflammatory signaling through DDR and cGAS‐STING. ATM‐NF‐kB pathway TBK1 CGAS NLRP3 TLR9 IRAK1 ATM IRF3 IRAK2 TRAF6 IRAK4 MYD88 PMC7599810__F1 Molecular pathogenesis of SARS-CoV-2 NLRP3 ACE2 PMC6442448__F13 Mechanism by which GBE attenuates diabetic atherosclerosis ATG12 ATF4 MTOR EIF2A XBP1 TRAF2 PMC8393346__F2 Risks and Function of Breast Cancer Susceptibility Alleles BRIP1 RAD51D ATR RAD50 BRCA2 NBN BARD1 RAD51C BRCA1 CHEK2 CHEK1 ATM PALB2 PMC8169786__F1 Recommendations for Vaccination in Children with Atopic Dermatitis Treated with Dupilumab: A Consensus Meeting, 2020 CD80 BCR STAT4 GATA3 PMC3255316__F1 Factors affecting the viability of dopamine neurons CCDC62 DRD2 GDNF CALB1 BDNF MCCC1 DRD3 PMC3615879__F4 Action of 20-HETE.Notes: Mitogens and ligands of G-protein-coupled receptors activate PLA2 and induce release of arachidonic acid, which is converted by CYP4A/F to 20-HETE EGFR GRB2 SRC PMC9181425__F4 Thirty Years’ History since the Discovery of Pax6: From Central Nervous System Development to Neurodevelopmental Disorders CDH2 REST NEUROG2 LZTS1 SOX2 PAX6 DSCAM TBR1 CUX2 CCND2 DMRTA1 HES1 HES5 PMC3073350__F1 Linking actin dynamics and gene transcription to drive cellular motile functions RHO PMC9293526__F7 miR-26a-5p Suppresses Wnt/Beta-Catenin Signaling Pathway by Inhibiting DNMT3A-Mediated SFRP1 Methylation and Inhibits Cancer Stem Cell-Like Properties of NSCLC MYC SFRP1 CTNNB1 PMC5852611__F1 Key players and stimuli in DRP1-mediated mitochondrial fission, both in physiologic and tumor conditions UCP2 CDC2 SUMO1 SUMO3 INF2 GDAP1 MFF SENP3 PMC4346874__F1 Apoptosis pathways in cancer BAX BAD FAS TRADD HEL-S-62p C9 TRAF5 APAF1 TRAF2 UNK FADD PMC3863730__F6 Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC10336275__F3 CREB-induced immune response RELA TRAF6 TNF IRAK4 MYD88 PMC6885218__F1 MTOR signaling pathway is involved in liver IR injury and plays crucial roles in autophagy ATG101 TSC2 RICTOR TFEB NRBF2 ATG14 ATM PTEN MTOR PMC4219296__F1 Wnt signaling pathway BCL9 MMP7 APC ROR2 GSK3B LRP5 LRP6 RYK NLK CCND1 CTNNB1 PMC2896868__F2 Toll-like receptors in kidney disease TBK1 TNFAIP3 TIRAP TLR9 CD14 SIGIRR TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 ATF3 TLR1 MAP3K7IP1 TLR3 TLR4 RELA TLR8 TLR7 LBP PMC3982103__F1 Astrocytic–Neuronal–Astrocytic Pathway Selection for Formation and Degradation of Glutamate/GABA MAL PC CIT PMC4742124__F1 Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma STAT3 GRB2 PMC11022384__F5 Therapeutic strategies targeting metabolism between GAMs and Gliomas ABCG1 HEL-S-90n SQLE ARG1 DHCR7 ABCA1 PMC8634714__F2 Latest Developments in Immunomodulation of Mesenchymal Stem Cells in the Treatment of Intrauterine Adhesions, Both Allogeneic and Autologous IL25 TSLP TRADD IL33 TRAF2 PMC11022384__F3 Metabolic characteristics of microglia GLS MTOR BDNF PMC11022384__F4 Metabolic interactions between tumor cells and GAMs GPD2 HEL-S-68p HIF1A PMC8619244__F5 TRPV4 Mechanotransduction in Fibrosis RHO NOX4 RAC1 PMC7865618__F3 Mechanism leading to CRS and ICANS and potential role of IL-1 blockade CD40 IFNG VWF PMC7865618__F2 Different treatment strategies to modulate the IL-1–IL-1R pathway NLRP3 IL33 IL36A IL36B IL1B PMC8619244__F2 TRPV4 Mechanotransduction in Fibrosis JUN SMAD2 SMAD4 MAP3K7 FOS PMC8619244__F3 TRPV4 Mechanotransduction in Fibrosis TRPM7 TRPC6 TRPC3 PMC8269357__F6 Identification of RNA-Binding Proteins Functionally Associated with Tumor Progression in Gastrointestinal Cancer ESRRB CDC2 ACHE TH STAT3 BAX CTCF SF3A1 RBM22 RPS3 MYC PMC9962262__F3 Clocking Epilepsies: A Chronomodulated Strategy-Based Therapy for Rhythmic Seizures GSK3B MTOR RORB RORA PMC11786704__S1 Preparation and application of PC capsules for promoting wound healing in diabetic mice BAX COX2 PC PMC7911265__F4 Portion of the human metabolic chart (online diagram: ), shown at its highest zoom level with all labels drawn, and displaying a reaction tooltip PNP CDA DPYD UPP2 TYMP MCEE GDA ADA PMC6405412__F12 Role of AKR1C2 and AKR1C4 in male virilization HSD3B2 HSD17B3 STAR HSD17B6 CYP17A1 CYP11A1 AKR1C2 AKR1C4 PMC6367847__F2 NLRP3 inflammasome pathways and putative mechanism by which cyclic stretch negatively regulates IL-1B secretion in murine macrophages NLRP3 TLR4 IL1B PMC7487603__F1 Endothelial cell migration during sprouting angiogenesis CDC42 HEL114 FOXO1 ROR2 FMNL3 VEGFA CTNNA1 RAC1 CTNNB1 PMC7882619__F2 Irisin: A New Code Uncover the Relationship of Skeletal Muscle and Cardiovascular Health During Exercise BAX VCAM1 MTOR PMC7697260__F3 Differences between the ECM− and ID+ fibroblast clusters are largely replicated in PDF and JDF spheroids, with distinct features present in PDF fibroblasts SLC25A5 NDUFB6 NDUFB2 NDUFS5 NDUFS8 COL3A1 CSF3 CXCL8 COXFA4 MME RIPK2 INHBA COX2 NDUFS6 ID4 ND3 NDUFB3 DCN ATP5G1 NDUFC2 UQCR11 LIF IL1A IL6 ID1 ID3 PDF CD44 COL6A1 ITGB1 HEL-S-125m RELA NFKBIA LAMA4 PS1TP5BP1 PMC5774508__F6 DEGs enriched KEGG map of the TNF signaling pathway in myocardial infarction IL15 FAS ITCH SELE TNF TRAF2 FADD PMC7697260__F4 Differences between the ECM− and ID+ fibroblast clusters are largely replicated in PDF and JDF spheroids with distinct features present in PDF fibroblasts SEC61A1 COL1A2 HEL-S-89n SEC61B COL3A1 ID1 PDF COL6A1 INHBA COL4A1 COL5A3 SPCS2 DCN PMC2792482__F3 Integration of lipid metabolic and inflammatory signaling in macrophages by LXRs TLR3 TLR4 NOD2 IRF3 TNF PMC3437946__F8 Synthesis and degradation of dopamine, norepinephrine, and serotonin TH TPH1 DBH MAOA PMC6019726__F1 Production of IL-32 and its downstream signaling network NOD2 NOD1 IL1B PMC5774508__F5 DEGs enriched KEGG map of the NFKB signaling pathway in myocardial infarction SYK EGF LTA TRADD TIRAP LAT RELB CD14 BLNK PARP1 LTB CNTF NGF BCR NFIB ATM LYN VCAM1 LBP LCK PMC2673908__F2 Unifying model of Wnt signaling with regard to cardiomyogenesis GSK3B LRP5 WNT1 LRP6 ARHA CTNNB1 PMC6627629__F6 Proposed mechanisms for fucoidan-mediated inhibition of osteoclastogenesis GSK3B PTEN NFATC1 PMC3580884__F3 Relationship between binding of ligands to the pattern recognition advance glycation end‐product receptor (RAGE), and inflammation, gene expression, oxidative and nitrosative stress, and damage to the macro‐ and microvasculature HMGB1 EGR1 ARC NCL PMC8476879__F3 Microglial Phenotypic Transition: Signaling Pathways and Influencing Modulators Involved in Regulation in Central Nervous System Diseases LPA NLRP3 SOCS3 MYD88 PMC3278439__F4 Analysis of the Fibroblast Growth Factor System Reveals Alterations in a Mouse Model of Spinal Muscular Atrophy CDC42 FRS2 ARHA GRB2 PMC4442787__F3 Of BK regulation, painful connections, and versatile neuropeptide signaling POMC MC4R NPY AgRP PMC4572416__F3 Pathways to AT2 cell injury/dysfunction defined by using mutant proSP-C isoforms as prototype substrates ATF4 EEA1 CD63 TRAF2 PMC9020799__F11 RRx-001 Exerts Neuroprotection Against LPS-Induced Microglia Activation and Neuroinflammation Through Disturbing the TLR4 Pathway NLRP3 TIRAP TLR4 TNF IL1B MYD88 PMC8058998__F1 Phosphorylation events in TLR signaling TBK1 MAL IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 BTK MAP3K7IP1 RIPK1 PMC4591933__F1 Non-invasive imaging and quantification of EGFR kinase activation in vivo EGF CIC EGFR CLC GRB2 PMC3579325__F3 Selected pathways from enriched injured (EI) versus non-enriched (i.e., STD housed) injured (NI): demonstrating calcium signaling importance CAV2 BCR DAO PMC9499793__F15 Therapeutic Effect of Gypenosides on Antioxidant Stress Injury in Orbital Fibroblasts of Graves' Orbitopathy BAX BCL2 MTOR PMC3808153__F7 The 5S RNP Regulates p53 Homeostasis and Its Activation in Response to Nucleolar and p14ARF OverexpressionSchematic overview showing the central role of the 5S RNP in coupling the pathway of ribosome biogenesis to cellular proliferation RPL5 RPL11 MDM2 PMC8088111__F6 Signaling pathways involved in the effects of Mg2+ on CLS mediated by the GAAC pathway and Ecl1 family proteins F2 EIF2A PMC5647277__F1 Current view of the mechanisms responsible for activation and modulation of the reproductive axis in birds and mammals DBP GNRH1 TSHB EYA3 PMC5363674__F1 Scheme of the unfolded protein response (UPR) ATF4 EIF2A XBP1 PMC3040753__F3 Gene Expression Profiling of Vasoregression in the Retina—Involvement of Microglial Cells EGR1 SERPINA3 CTSS HLA-DPB1 B2M HLA-DPA1 C4A FOS KLK6 CD74 CFP HLA-DRB4 CP PMC10178209__F4 Biosynthetic pathway to produce patchoulol and Alpha- and Beta-santalol in S IPP PTS IDI1 PMC4818358__F1 Roles of interleukin-10 (IL-10) in determination of pregnancy VIT STAT3 JAK1 PMC5480029__F1 Sulfide (S2−) homeostasis and small-molecule chemistry that couples reactive sulfur species (RSS) and reactive nitrogen species (RNS) LIPA FES PMC7197376__F1 Manipulating a tumour suppressor CDK6 HMGA2 SOX2 CDK2 CDK4 PMC8616335__F5 Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer MCC ATM PMC2718491__F3 Multiple regulatory pathways for N-WASP and WAVE2 activation CDC42 ABI2 SHD ABI3 SRA1 PMC9180634__F1 Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide PGC STAT1 SOX9 FGFR3 CNP GRB2 CCND1 PMC3536698__F8 IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling TBK1 MAVS TLR3 IFIT1 IRAK1 IRF3 TLR7 RSAD2 CXCL10 TRAF6 MYD88 PMC4162362__F1 The sphingolipid signaling pathway SPNS2 SPHK2 SPHK1 PMC7343375__F2 Abbreviated diagrammatic representation of the PI3K, Akt, mTOR cell signaling pathway, and associated pathways, as a major regulator of cell function (see Laplante and Sabatini for a more extensive chart of mTOR-related cell signaling) RHEB PGC GRB10 TSC1 TFEB TBC1D7 PTEN DEPTOR PMC9406872__F1 Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer HHIP SUFU PTCH1 GSK3B SMO GLI3 PMC5098276__F4 CCI-779 treatment induces expression change in mTOR signaling pathway components RHEB TSC2 RICTOR BRAF HIF1A MTOR EIF4E PMC8750192__F8 Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis TIRAP TRAF6 CCL2 TNF MYD88 PMC9481585__F6 Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355 C2 F8 PMC6478395__F3 BRAF mutations on tumor cell survival and the tumor microenvironment BRAF NRAS PTEN MTOR PMC3443855__F7 Nodal Signaling via an Autocrine Pathway Promotes Proliferation of Mouse Spermatogonial Stem/Progenitor Cells through Smad2/3 and Oct-4 Activation SMAD2 SMAD4 NODAL CCND1 PMC9406872__F2 Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer HHIP PTCH1 PTEN MTOR PMC8750192__F1 Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis CD80 TIRAP MAL TLR9 IRAK1 TLR5 TNF TRAF6 CCL2 CXCL8 MYD88 TLR1 TLR3 TLR4 TLR7 IL1B PMC9406872__F3 Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer SHH IHH PMC3588864__F7 Possible mechanisms of estrogen/androgen action in the prevention of NAFLD/NASH UCP2 HMGCR F2 PMC6504231__F8 Functional interplay of IL-21 with type I interferons in the response to MRSA STAT3 IL21R PMC9321204__F4 Glycine betaine uptake and metabolism in marine microbial communities HEL-S-61p PMC9599896__F2 Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma CDH2 EGFR GSK3B AXIN2 CTNNB1 MZF1 PMC11546914__F3 AI-Assisted Identification of Primary and Secondary Metabolomic Markers for Postoperative Delirium AARS1 CD40 IFNG SYK IL10 ITGAM LEP KARS1 ATF4 IL6 CCL2 CD68 PMC10507829__F4 Illustration of contributing factors of the signaling pathway for DDR1 in human adipose-derived MSC (A), (B), (C), which generated using ReactomeFIPlugIn in Cytoscape (B and C—enlarged parts of the image A) RUNX1 RUNX2 RUNX3 PMC10507829__F1 Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells STAT3 RAF1 PXN FLNA CAMK2A FYN HSPB2-C11orf52 PDPK1 PRKCA WAS KDR SRC ARHGAP35 VAV3 CTSL VEGFA DOCK1 HRAS CRK RAPGEF1 BCL2 GRB2 CDC42 EGF BAD VASP EGFR AKT3 ZYX PAK4 PTEN SHC2 CTNNB1 ARHGEF12 TLN1 MYL12B CCND1 EMP2 JUN ARHA DROSHA RAC1 ARAF CD44 HOXD10 PLCE1 ITGB1 ACTN4 MAP2K1 PMC4431617__F1 Schema of the PI3K pathway TSC2 PTEN MTOR CCND1 PMC2063513__F6 Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling EPHB4 ITGB6 HCN2 RECK MMP9 LAMB1 PMC8348949__F2 Netrin-1 in Glioblastoma Neovascularization: The New Partner in Crime? NTN1 SHH SMO PMC6668446__F6 GLI1 activation by non-classical pathway integrin AvB3/ERK1/2 maintains stem cell-like phenotype of multicellular aggregates in gastric cancer peritoneal metastasis BMI1 SUFU SMO PMC5831511__F3 Brain-immune interactions in perinatal hypoxic-ischemic brain injury IL10 SMAD2 IRAK1 TRAF6 PMC5038987__F6 Proposed mechanism of the priming phase of complement-induced liver regeneration HMGCR CH25H SOCS3 PMC5014907__F3 CD4+ T cell activation by antigen presenting cells and the IL-12/STAT4 pathway SOCS1 CD80 TNFAIP3 TNFRSF1A APC IL7R IRF8 CTLA4 IFNG STAT4 TYK2 LCK IL12RB1 PMC7674124__F1 Expression of PROK1 (A) and PROK2 (B) TBX20 PROK1 PROK2 HIF1A PMC8592567__F2 Candidate signaling cascades that mediate the action of Indigo and polysaccharides via the gut AIP AHR IRF3 PMC4925815__F1 Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation TLR1 COX2 TLR4 IL18 CD14 IRF3 IRF8 LBP PMC3615902__F3 Developmental data alters disease mechanism prediction KIF15 HEL164 ADCYAP1R1 DLGAP5 CGA CDC20 BUB1B HMMR CDC6 NEK2 SFN CENPE CDT1 PLA2G2A KIF23 BIRC5 EREG INHBA DKK1 CDKN3 TPSAB1 CDC2 CENPF CXCL13 NUF2 SELE LIF SERPINA1 FABP4 MKI67 IGF1 MCM10 AURKB DIPLA1 HSPA4 CFTR CENPA TWIST1 HCTP4 PMC7752075__F2 Synthetic pathway of NO in ECs, inducers, inhibitors, the roles played and the effects of different components of the ECM CD36 SRC CD47 PMC8012816__F7 Model depicting that PER3 regulates stemness of PCSCs via WNT/Beta-catenin pathway PER3 CTNNB1 PMC7824309__F3 Pathway enrichment analysis EGF PEMT PMC7162481__F4 Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer EMSY NAF1 EVI1 TCF2 TWIST2 KRT19 CD58 BCL2L2 ADRA1B ALK ALOX5 ZEB2 GRIN1 MDM2 MAPK1 GPR65 SP1 FLOT1 BHLHB2 SKI XPC RAD21 CDKN1A BCL2 FPR2 HOXB13 RNF111 CP KRT18 RPS6KA2 SCNN1A GAS2L3 HADHB MAML3 KDELR2 IL2 CCND1 DNMT3B RBM38 CDC2 FOXA1 SDCBP NFATC1 CD40LG NR3C1 STK39 IL6ST JAK1 LYN PMC3581534__F7 Bridging HIV-1 Cellular Latency and Clinical Long-Term Non-Progressor HESX1 CDON TCN2 APOO LIPC CSF2RB MYCBP STAMBPL1 YIPF6 PHF3 SLC26A3 SLC25A2 CRAT APOD MAPRE3 MPZL1 KRT14 AREG ARL4C TNLG2B NEFH ERBB3 PHB2 CXCL11 CYFIP1 UGDH SDK2 RGS13 NPL NPPB RBM28 PMC8020202__F2 Roles and mechanisms of CBS/H2S and CSE/H2S system in breast cancer STAT3 INS SIRT1 PMC3581534__F5 Bridging HIV-1 Cellular Latency and Clinical Long-Term Non-Progressor: An Interactomic View HEL107 PCYT1B PPIB PPIE TXNIP PSMC1 LGI1 ASPA KPNA2 RPS27 HEL-S-99n ELAVL2 F3 SNRPB MCM9 Nbla10236 HHEX XK PPY CAT56 CYP2C18 MCM7 LILRB4 CLPP FES OPN1SW PMC8336719__F1 Roadmap for AHR targeting in skin inflammation KYNU AHR AHRR OVOL1 PMC6901966__F10 Protective effects of farrerol on CDDP-induced AKI and the underlying mechanism BAX NLRP3 KEAP1 NOX4 PMC4277277__F2 Snapshot of the Hepatic Transcriptome: Ad Libitum Alcohol Intake Suppresses Expression of Cholesterol Synthesis Genes in Alcohol-Preferring (P) Rats HMGCS1 IDI2 HMGCR EBP SQLE PMVK MVD DHCR7 FDPS MVK PMC6362265__F1 Three branches of the unfolded protein response (UPR) ELF2 ATF4 EIF2A TRAF2 PMC9131376__F4 Recent Progress in the Development of Novel Mycobacterium Cell Wall Inhibitor to Combat Drug-Resistant Tuberculosis FAS INHA PMC5725016__F10 Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3) DKK3 GALNS PMC4481438__F1 Effect of ileal bile acid transporter in the proximal ileum CYP8B1 CYP7B1 CYP27A1 PMC6868851__F3 Mechanism of miR21 in PC development BAD PTEN MTOR PMC3663255__F1 Notch signaling pathway NUMB FURIN HES1 RBPJ HES5 PMC9529349__F1 Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome TH GSDMD NLRP3 MYD88 PMC11661909__F4 Metastatic brain metastasis STAT3 BRD4 JUN PMS2 MSLN CERS1 EGFR ENPP1 RAC1 CTNNB1 CD44 HLA-G PDGFRA MMP3 MUC1 DOCK4 CXCR4 RET PMC11685086__F1 FSH functions through the FSHR HMGCR LDLR UCP1 VCAM1 FSHR PMC6354556__F1 Role of the biomarkers explored in the study on EGFR signaling STAT3 HGF AXL PXN MOG EGFR GSK3B HEL-S-28 SRC YAP1 CDCP1 CTNNB1 PMC9343460__F8 Effect of PINK1 on Alzheimer’s disease-like pathology induced by intracerebroventricular injection of forskolin in rats KEAP1 NQO1 GSK3B MAF PMC11685086__F2 Action of FSH-FSHR in OC proliferation and EMT CDH2 SPHK2 SPHK1 PTEN FSHR CCND1 PMC11685086__F3 Nanotechnology and immunotherapy for ovarian cancer (OC) targeting FSHR HK2 CD8A FSHB PMC4194125__F8 Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer SDHA DLAT FH SLC2A12 SLC38A1 DLD HIF1A SLC7A5 HEL-S-26 PMC6397348__F9 Diagram: BPI fold-containing group A member 1 (Bpifa1) regulation of noncanonical Toll-like receptor 4 (TLR4) and interferon (IFN) signaling IFNG STAT1 STAT2 TLR4 IRF9 BPIFA1 IRF3 IRF7 STAT4 CXCL10 IL12RB1 MYD88 PMC5192300__F2 The cellular trafficking of CD1 molecules CD1A CD1C CD1D PMC4107957__F1 Toll-like receptors and TLR-mediated signaling pathway TBK1 TIRAP TLR9 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC5746140__F3 Implication from RAS/RAF/ERK signaling pathway increased activation in epirubicin treated triple negative breast cancer POR CS MTOR PMC9291299__F4 Translation initiation and its relevance in colorectal cancer EIF4B ABRA EGFR APC GSK3B LRP5 LRP6 PTEN EIF5 EIF4E RHEB TSC2 TSC1 ELF1 SUI1 ATF4 GRB2 EIF2A ELF5 ELF3 PMC8935981__F10 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches FANCD2 ATR RAD50 RAD51 MSH2 PCNA BRCA1 NR3A2 BRCA2 ATM XPC PMC6034042__F4 Nicotinamide Adenine Dinucleotide (NAD+) synthesis pathways NAPRT NAMPT PMC6768428__F1 The STING signaling pathway TBK1 CGAS ZBP1 DDX41 IRF3 PMC2148066__F6 GenMAPP pathway showing changes in expression of the transcription factor PPARA and fatty-acid degrading enzymes upon fasting LPL ECHS1 EHHADH CRAT ACADSB ACADS ACADM NR1C1 HADHB GPD2 ACADVL ACADL CPT2 PECR CPT1A PMC8759737__F1 SHP2-associated Noonan syndrome in RASopathy CSH2 GRB2 PMC10573607__F4 Soluble sugar, cellulose, and lignin contents JUN CAD IRX1 PMC7899014__F10 Cell signal transduction pathways of 7 central hub genes in CMs infected with SARS-CoV-2 JUN CCR2 PLG IRF3 IRF7 TRAF6 CCL2 CXCL8 FOS MYD88 IL1R1 STAT1 FYN TLR4 IFNB1 MAP2K3 ACE2 PMC11215092__F1 Molecular pathways and targeted therapies in head and neck cancers pathogenesis STAT3 JUN WWC3 EGFR LRP5 LRP6 PTEN MTOR MYC AXIN2 CTNNB1 LATS1 FBXW7 AXIN1 CREBBP EP300 GRB2 PMC3568707__F1 BiP as master regulator of the Unfolded Protein Response ATF4 EIF2A XBP1 PMC1999497__F2 Flow diagram of the P53/apoptosis pathway BAX BCL2 APAF1 PMC8663982__F4 Cytokine signaling inhibition on inflammation-driven tissue remodeling STAT3 STAT1 PMC8663982__F5 Cytokine signaling inhibition on inflammation-driven tissue remodeling MAP3K7IP1 SMAD2 SMAD6 SMAD4 BMP7 MTOR PMC2680287__F1 Unraveling the complexities of the interferon response during SARS-CoV infection PYCARD IFNA13 NFKB2 CD69 IFIT1 IFIT3 IFIH1 IFIT2 CD84 CCL5 CCL2 CR1 ISG20 IFNG CD83 STAT1 IFNGR2 IFI44 OASL NFKBIE MX2 MX1 OAS1 OAS2 IL1B CD48 IFNGR1 STAT2 IRF9 IFI16 IRF3 IRF7 IL6 OAS3 TNF IRF6 TLR1 TLR3 NFKB1 IRF2 IFNAR1 NFKBIA JAK1 IFNB1 TYK2 NFKBIB CARD9 PMC7293224__F7 Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway ATG3 MTOR PMC10559873__F6 Detail of pathways TH COX2 SELE FRK KL PAH LCN2 TNF S100A9 FADD PMC5986469__F7 Illustration of the Compound-Group-Target-Pathway (CGTP) network NR1i1 HEL111 RBP4 ALB NR3C2 MME F2 HEL-S-69p IL2 CDK2 ELANE FDPS SRC PMC9180951__F5 Review on the Role of Bicarbonate and Proton Transporters during Sperm Capacitation in Mammals SLC26A3 SLC4A1 HVCN1 PMC7573281__F4 Signaling pathways over-represented by genetic variants and differentially expressed genes Over-represented pathways and related genes are plotted SYN2 THBS1 CADM1 ARHG FEN1 PCNA KALRN FARP1 RAC1 OGG1 GP6 LIG1 COL9A3 ITSN2 APEX1 PLCG2 POLG SNAP25 POLE PMC5986469__F8 The interaction effects of enriched KEGG pathway terms and putative target proteins identified in the present study IDE MAPK11 EGFR HEL111 APOE PLG TNF ALB HRAS F2 FGFR1 C9 MMP3 IL2 CDK2 APP MAPK10 MAP2K1 SRC CD68 PMC7849831__F2 Mitochondrial dysfunction in astrocytes contributes to neuroinflammatory activation of astrocytes CGAS PINK1 NLRP3 PMC5273810__F4 IFN-gamma signaling pathway IFNG CRK MAK FANCC PMC5273810__F6 Network analysis using key molecules in VL pathogenesis SOCS1 BRD4 STAT3 ZAP70 SUZ12 SYK HGF TRADD EGFR GSK3B PTEN HIF1A MYC RUNX2 TRAF6 FGFR2 IFNG STAT1 FGF7A E2F3 FGF9 PLCB3 CREB1 JUN CBX2 FRS2 SP1 E2F2 LIF SOX2 HEL-S-28 IRF1 IRF8 PTPN6 IRS1 HRAS IGF1 ADAM9 CDK2 JAK1 LYN MAP2K1 GRB2 IL13RA2 TRAF2 FADD PMC9709153__F6 Molecular mechanisms of exercise contributing to tissue regeneration TIMP3 SOST BCL2 PTEN ATF7 HIPK1 PCDHJ MTOR CCND1 SIRT1 PMC11312265__F1 Molecular mechanisms of inhibited and activated canonical Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 CTNNB1 PMC11312265__F2 Signaling cascade of non-canonical Wnt/PCP and Wnt/Ca2+ pathway CDC42 ROR1 ROR2 PTK7 RYK RHO NLK RAC1 DAAM1 CTNNB1 PMC9709153__F4 Molecular mechanisms of exercise contributing to tissue regeneration NRG1 ERBB2 POLI CCND1 CDK4 PMC9709153__F2 Molecular mechanisms of exercise contributing to tissue regeneration PIEZO1 SOST LRP5 HDAC5 LRP6 PMC11312265__F5 Non-canonical Wnt/PCP and Wnt Ca2+ signaling and their implications in cancer CASR CD44 VANGL1 RHO NLK PMC9709153__F3 Molecular mechanisms of exercise contributing to tissue regeneration CITED4 NRG1 IGF1 IGF1R MTOR BDNF PMC9174462__F1 Pyroptosis and Its Role in Autoimmune Disease: A Potential Therapeutic Target BAX GSDMD NLRP3 GSDMB AIM2 DFNA5 IL1B PMC11802527__F2 Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure APOC3 SYK IL1R1 GSDMD NLRP3 SCIMP RIPK1 LYN PMC9602726__F5 GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway CEP290 PIK3CA EPHA2 ENO2 NCOA6 PUM2 GPN3 TUBA4A AK2 EEF1A1 PI4KB IWS1 POLR2C HEL-S-2 CDS2 SP1 NME7 RHOBTB3 TFDP1 CNOT8 KAT6A TSG101 B2M PID1 POLE4 MEN1 CDKN1B GJA1 PMC4855686__F2 CAMs can activate neurite outgrowth through different mechanisms CDC42 TAF1 PCDH7 L1CAM APC CELSR2 CELSR3 RAC1 CTNNB1 PMC2848237__F2 Reconstruction of a KEGG pathway CDC20 CDC6 CLN3 PMC1952230__F1 Regulation of CXCR4 Signaling CDC42 RHO SRC PMC4972100__F1 The serine synthesis pathway and downstream anabolic reactions of serine PHGDH PSAT1 PSPH PMC10982391__F1 Direct immunomodulatory function of TDEs on CD8+ T cells BMI1 OGT FAS HLA-G ARG1 PMC10982391__F2 TDEs indirectly regulate CD8+ T cells via the TME cells PIGF ARG1 LGALS9 MMP9 PMC9598036__F4 Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics APOE BACE1 LINGO1 ARG1 MTOR ABCA1 TREM2 NRG1 FYN ITGB1 BDNF CSF1R NOTCH1 HES5 PMC7583029__F1 Plant abiotic stress perception and response, concerning different cell compartments/organelles, and the terpenoid biosynthesis pathway IPP MOS MVP MVD HEL-S-11 PMC9406972__F2 Tumour Derived Extracellular Vesicles: Challenging Target to Blunt Tumour Immune Evasion IFNG CD80 FAS APC IL10RA CTLA4 IL10RB PMC4673119__F1 Regulation of T follicular helper cells by ICOS S1PR1 ICOS SELL FOXO1 SELPLG CCR7 TBX21 PMC6167501__F1 Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy JUN PYY NF1 GRB2 MYC FOS PMC2939308__F1 Activation of PPARG and PTEN Cascade Participates in Lovastatin-mediated Accelerated Differentiation of Oligodendrocyte Progenitor Cells NTS SP1 HEL-S-62p MBP PTEN SOX10 CDK4 PMC4035704__F3 Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP RHEB TSC2 TSC1 FOXO1 PMC6167501__F7 TGFB signaling pathway in melanoma TGFB1 ARHA PMC6167501__F8 Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy DLL4 JAG2 NOTCH2 NOTCH3 FURIN DLL3 NOTCH1 PMC6167501__F2 PI3K-Akt pathway activity BAD FOXO1 PDPK1 PTEN MDM2 MTOR PMC6167501__F4 Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy BCL9 APC GSK3B CTNNB1 CP PMC5567140__F4 NCL expression affects cholesterol synthesis GGPS1 IDI2 CYP51A1 MSMO1 EBP SCD SC5D DHCR24 ACACA ME1 FADS1 HMGCS1 HMGCR PMVK MVD DHCR7 FDPS IDI1 ELOVL6 HSD17B7 NCL PMC6167501__F5 Canonical and non-canonical NFKB signaling pathways CD40 LTBR RELB TRAF5 REL TRAF2 PMC9036418__F1 3q26 CNG activates PKCι-driven oncogenic signaling pathways in LUSC PAK1 ECT2 SOX2 RAC1 PMC11393980__F8 Other targets of pVHL in ccRCC and SNC hemangioblastomas TBK1 SFMBT1 ZHX2 SPHK1 PMC5923293__F6 Ingenuity pathway analysis (IPA) of miR-152-3p-target interactions in prostate cancer signalling RB1 LEF1 PMC10831402__F2 Suggested PML/RARA-related signaling pathway that leads to cell proliferation and the evasion of apoptosis JUP RARA CDKN1B PML CDK2 CTNNB1 PMC7392626__F1 cGAS-STING pathway in oncogenesis and cancer therapeutics TBK1 CGAS TANK IRF3 TRAF3 ENPP1 TRAF2 PMC7392626__F2 cGAS-STING pathway in oncogenesis and cancer therapeutics CXCL11 CD80 CGAS RAE1 IRF3 IL6 PMC9598036__F3 Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics LPL TREM2 FYN RTN3 APOE LINGO1 ARG1 ADAM10 MTOR HES5 PMC3253886__F4 IRF signaling pathway that was generated from pathway analysis of proteins with significant fold changes across both studies IL10 MAVS TLR3 IFNA4 IRF3 PMC8663982__F2 Cytokine signaling inhibition on inflammation-driven tissue remodeling MAP3K7IP1 NLRP3 TLR4 IRAK1 TRAF6 PMC10135928__F7 Lipid synthesis in adipocyte differentiation and functions TG DGAT1 CD36 EBP DGAT2 FASN MSC PMC5338429__F7 Model of Gata4 transcriptional regulation in atrial septation PTEN GATA4 CDK4 PMC8663982__F3 Cytokine signaling inhibition on inflammation-driven tissue remodeling SMURF1 TRADD TLR4 MTOR PMC7075706__F4 Intracellular pathways involved in proinflammatory effects of soluble uric acid CARD8 NLRP3 IL1A IL6 MTOR IL1B PMC3774987__F3 Essential TLR-associated signaling pathways and cytokine production TLR1 TIRAP TLR3 TLR4 TLR5 IRF3 TRAF3 TRAF6 TLR10 IRAK4 MYD88 PMC6225629__F4 Reconstructed metabolic pathways (KEGG) of S LPA HEL107 RPE RPIA HEL-S-162eP HEL-S-5 PMC5372268__F4 KEGG pathway hsa05200 “Pathways in cancer” RARA KMO CRKL PMC4965259__F1 Presence of both alterations in FGFR/FGF and PI3K/AKT/mTOR confer improved outcomes for patients with metastatic breast cancer treated with PI3K/AKT/mTOR inhibitors PTEN GRB2 MTOR PMC7759681__F3 Function enrichment analysis of survival-related DEGs in STAD MASTL CDO1 AGO2 CCL15 RCC2 DTX4 NMB EPB41L3 PFKFB2 TFF2 TFF1 TACC3 PDE1B SPATA13 POLE GHR ZFP36 SOX17 ANKRD1 EFNA4 MSH2 TFDP1 WDR62 LMNB2 CCL14 TCF3 MTBP SFMBT1 RAF3 TTF2 MCM2 UHRF1 RBP7 KIF15 RGS2 CD36 CLSPN MICU3 FBXL7 CCNO KIF24 LFNG CIT KLHL17 CASP2 NAA40 ENTPD6 SAMD12 SLC12A7 COPZ2 KIT DNAAF3 FABP4 MMRN1 TMEM63A HEL-S-70p DBF4B TMEM201 NAA25 P2RY14 CCDC15 INCENP RMI1 PMC1993849__F7 Ischemic/hypoxic effects on cardiac myocytes and stem cells STAT3 MSC TNF PMC3912696__F1 Role of cytokines in Th1 and Th2 differentiation of lymphocytes CXCL9 IFNG CCL24 IL10 CCL22 CXCL10 TNF CCL17 PMC10903931__F1 Hepatic phospholipid biosynthesis pathways TG PSD PEMT PMC5134418__F2 Depiction of prasugrel metabolic pathway CYP2B6 CYP2C19 CYP2C9 CYP3A4 PMC6755131__F7 Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway PLCG2 FPR2 PMC10903931__F4 Apoptosis model induced by fatty acid metabolism BAX TG PC PMC10903931__F5 LXR-LPCAT3-ERS signaling pathway LPCAT3 ATF4 EIF2A TNF XBP1 TRAF2 PMC8785421__F1 Signaling pathway and polymorphisms of Mrgprs TRPA1 KCNQ2 ORAI1 TRPV1 TRPC3 PMC7047232__F6 Cartoon presentation of proposed cellular and molecular mechanisms for the synergistic effects of ATO/AA combination treatment CASP9 BCL2 IL1B PMC6002396__F8 Model depicts the multiple mechanisms by which NXT inhibits the development of diabetic nephropathy in db/db mice TGFBR2 TGFB1 INSR SMAD2 MMP2 GCK VEGFA PMC8615685__F3 Alterations of Plasma Galectin-3 and C3 Levels in Patients with Parkinson’s Disease NLRP3 TLR4 C4A IL1B PMC1853294__F10 Cell injury to wound closure, including P2Y activation, intracellular Ca2+ release and EGFR signaling EGFR ERBB2 SRC PMC3321306__F1 Gene expression network of the heritable transcripts in the nuclear factor kappa B signaling pathway HMGB1 TRADD NPM1 AHR PMC10607207__F1 Neuroprotective intracellular signaling pathways in the central nervous system involving TRPC6 activation STIM2 TRPC6 BDNF PMC8350724__F1 Pyroptosis, a New Breakthrough in Cancer Treatment NLRC4 NLRP1 GSDMD NLRP3 IL18 AIM2 IL1B PMC3955095__F2 Targeting the Bcl-2 Family for Cancer Therapy BAX BAD DIABLO PMC8350724__F2 Pyroptosis, a New Breakthrough in Cancer Treatment GSDMD NLRP3 IL1B PMC3937760__F4 miR-182 plays an important role in CEBPA/miR-122/IGF1R pathway CEBPA GSK3B IGF1R CCND1 PMC4355251__F2 PRR and signaling pathways that lead to differentiation of antifungal T-helper cells TH SYK MAL TLR9 TNF MYD88 TLR1 BCL10 NLRP3 TLR3 IL16 TLR4 TLR7 REL PMC3887856__F1 Two branches of pathway upstream of mTORC1 RHEB SLC3A2 TSC2 MAP4K3 TSC1 IGF1 SH3BP4 PTEN SLC7A5 DEPTOR IRS1 PMC9085237__F16 Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties RHEB TSC2 TSC1 HK2 TIGAR PMC5436143__F6 Gain of function Beta-catenin in the uterine mesenchyme leads to impaired implantation and decidualization PGR PTCH1 LIF BMP2 IHH WNT4 PMC3887856__F3 SH3BP4 is a potential tumor suppressor functioning in the amino acid-mTORC1 pathway RHEB TSC2 TSC1 IGF1 SH3BP4 PTEN PMC4961512__F8 Curcumin and PKC signaling pathway in colon cancer UGT1A1 EGR1 EGFR PMC6690952__F7 Schematic diagram depicting the mechanism by which suppressor of cytokine signaling 5 promotes or inhibits hepatocellular carcinoma cell metastasis via phosphoinositide-3 kinase/Akt/mammalian target of rapamycin pathway-mediated autophagy SOCS5 MTOR PMC10193376__F4 Protein network encoded by jointly regulated genes MMP16 MMP25 MAP3K10 RNF123 EGFR ZNF652 PTEN COL10A1 MYLK ZNF117 BCL7A VPS18 TP53INP1 E2F2 CFH MYO6 CCDC6 S100A1 ZNF28 ZNF254 ZNF493 TBC1D14 ZNF561 ZNF611 ZNF431 CDC40 VPS51 KLF13 PMC5346713__F8 Differentially expressed miRNAs in triple negative breast cancer between African-American and non-Hispanic white women PURA SERPINB5 WNT3A SMAD2 BMP2 PNPT1 MYC DROSHA MAD2L1 PMC5037849__F2 Dock3 signalling pathways in optic nerve regeneration ARHG DOCK3 APC GSK3B RAC1 PMC5746010__F1 Interactions of ALS/FTD associated genes with autophagy pathway TBK1 RAB1A ULK1 ATG14 VCP ATG101 YOD1 VAPB RAB8A NRBF2 WDR41 SMCR8 OPTN C9orf72 PMC446107__F1 TLR signaling pathways TLR1 TIRAP TLR3 TLR4 MAL TLR9 TLR8 IRF3 TLR7 MYD88 PMC4116751__F1 Model Genetic Pathways MED23 EGF EGFR KSR1 GRB2 PMC5803300__F8 ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway ANKRD11 BDNF PMC7910861__F1 Evasion of RLR-mediated innate immunity through viral manipulation of ubiquitination and ISGylation TBK1 MAVS USP15 USP27X TRIM25 IRF3 IRF7 ISG15 CYLD PMC10420321__F8 Molecular mechanism underlying the beneficial effects of FJE in the OVA-induced CARAS mouse model TSLP IL33 PMC5790772__F1 Heparan sulfate proteoglycan (HSPG) protein family organization and HS biosynthesis C2 EXT1 PMC3775637__F3 Targeting the PI3K and BTK pathways in NHL RHEB SYK TSC2 BTK TSC1 PTEN MDM2 MYC PMC5363240__F5 Proposed role of RUNDC3B in the MAPK signalling pathway MAX CRAT MOS SMAD4 RUNDC3B MYC PMC3398478__F1 MAPK Pathways in S CDC42 TF SOST PMC5091087__F5 DEVELOPMENTAL CIGARETTE SMOKE EXPOSURE II: HIPPOCAMPUS PROTEOME AND METABOLOME PROFILES IN ADULT OFFSPRING ECHS1 PGAM1 NAPB CCT6A ENO2 HEL-S-68p ENO1 MDH2 HEL-S-30 PMC4511315__F1 Schematic diagram for signaling regulation of acetylcholinesterase (AChE) ACHE EGF FGF2 PMC5319910__F4 Histone chaperone networks shaping chromatin function NASP TLK1 HAT1 TLK2 IPO9 MCM2 TONSL HIRA PMC8687848__F8 Geniposide Attenuates Hyperglycemia-Induced Oxidative Stress and Inflammation by Activating the Nrf2 Signaling Pathway in Experimental Diabetic Retinopathy GLP1R GFAP TNF PMC3821554__F1 The TGFB signaling pathway is regulated at multiple points by ubiquitin-mediated targeting and proteasomal degradation SMAD4 PMC7347075__F1 Metabolic kynurenine (Kyn) conversion pathway HEL-S-90n IDO1 KYNU KMO PMC4723075__F10 Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1ß Induction of Interleukin 6 in the Developing Enterocyte IL1R1 JUND JUNB IRAK1 TRAF6 PMC3754784__F1 Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis TBK1 TIRAP TLR9 IRAK1 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC4197719__F1 Mechanism of canonical HH signal transduction in vertebrates GSK3B SHH SMO GLI3 PMC9022290__F2 CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate ACSL1 CD36 FABP4 CPT2 PMC8615614__F1 Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma RHEB TSC2 TSC1 GSK3A GSK3B PTEN MDM2 PMC9669749__F2 Inflammatory pathophysiological mechanisms implicated in postpartum depression NLRP3 IL6 FOXP3 PMC3312677__F8 Genetic pathways involved in the regulation of the Mesp2 pathway RIPPLY2 MESP2 MAML1 TBX6 LFNG EPHA4 PMC4364943__F10 Proposed model for the integration of NFAT and NFKB signalling pathwaysSwollen AF conidia are taken up by macrophages SYK BTK TLR9 MYD88 PMC4937511__F10 Three pathways identified as altered based on the 12 SCI biomarker candidate proteins as input ALB HEL-S-99n GOT2 NR1C1 FASN ELL HEL-S-87p PMC3491811__F3 Calcium regulation of keratinocyte differentiation FYN RHO SRC CTNNB1 PMC4283519__F1 Signaling pathway interaction and effects of modulators: cGMP and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of platelet aggregation in patients with metabolic disorders VWF COX1 GC IL1A PMC4306233__F2 Roles of F-box proteins in cancer JUN FBXW7 MCL1 MYC SKP2 DEPTOR CTNNB1 FBXO5 PMC5082387__F2 TAM-dependent immunity IFNE IL10 STAT2 APC ARHA PMC5173117__F3 Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer SMS SRM PMC6830349__F2 Cell structure and function UFD1L ADRM1 YOD1 CDK5 C2 SCAI CLN3 PMC3494767__F5 Synergistic cancer cell death in response to stress when TSC2, but not Pten is inactivated in the context of a deregulated Rb pathway TSC2 TSC1 PTEN CCND1 PMC8246597__F11 AMBRA1 regulates cyclin D protein stability and signalling through the RB pathway RBX1 DDB1 CDK6 CUL4B AMBRA1 CDK4 PMC7695248__F6 Sex-dependent metabolic and transcriptional changes after disrupted Cyp51 from cholesterol synthesis align with hepatocarcinogenesis in humans HEL-S-22 TG NR1C1 SF1 GYS2 CD36 CYP7A1 CYP7B1 GCK GHR PMC5436606__F1 PD-1 and CTLA4: Two checkpoints, one pathway? APC LCK PMC6830349__F3 Diagram that illustrates the in situ flow of downregulated proteins (mark in green) in early development as a consequence of cAMP stimulation ACLY GTPBP4 AOAH LACTB SCD PITRM1 GRWD1 GFM1 PISD GATB PMC8758946__F1 Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation TBR1 LMX1A MSX1 LHX3 PAX6 RET PMC8037903__F1 Role of gut in inducing adipose tissue inflammation TLR4 CD14 LBP PMC6927425__F4 Targeting Wnt signaling to combat cancer APC CTNNB1 PMC11617596__F3 NAT10 plays a critical role in cancer YTHDC1 FOXM1 AXL ANKZF1 NAT10 TFAP2A NOTCH3 AHNAK CEBPB MAST1 PMC11617596__F4 Ac4C‐related signaling pathway in cancer CDH2 NAT10 CCND1 CTNNB1 PMC6927425__F2 Non canonical Wnt signaling CDC42 ROR2 ARHA PMC7730553__F8 When LPS binds to TLR4 in the cell membrane, the resulting complex can lead to the activation of adaptor proteins including MyD88 and TIR-domain-containing adapter-inducing interferonB (TRIF) TIRAP COX2 IL16 TLR4 MYD88 PMC12086256__F5 Interactions of vascular endothelial growth factor receptors (VEGFR) with co-receptors and structural features of Neuropilin CD44 EGFR FGFR1 NRP2 EPHA4 FGF2 PMC12086256__F6 Signal transduction of vascular endothelial growth factor receptors CRK FYN SHB GRB2 SRC PMC12086256__F7 Negative regulation and fine-tuning of VEGFR2-mediated signaling pathways PLCG1 VEGFA SRC PMC12086256__F8 VEGF/VEGFR signaling controls angiogenesis and vascular permeability PC SRC PMC12086256__F9 VEGF/VEGFR signaling under pathological conditions VEGFB VEGFC PIGF MMP9 VEGFA SRC PMC3472969__F1 Genotypic-phenotypic model of estrogen metabolism and exposure (yellow box represents genotype component with phenotypic factors outside) CYP1B1 CYP1A1 H1-2 PMC11576426__F5 KEGG pathway “Regulation of actin cytoskeleton” (ssc04810) ABI2 FGF8A HEL114 LPA FGD1 F2R PXN F2 APC RHO CXCR4 INS PMC8920679__F3 Cellulosic Ethanol Production Using a Dual Functional Novel Yeast ADH7 ACO2 ENO2 PGM3 PGM2 PDC HEL-S-4 PMC3281071__F4 RNA-seq Reveals Novel Transcriptome of Genes and Their Isoforms in Human Pulmonary Microvascular Endothelial Cells Treated with Thrombin EGF SOS1 EGFR RHO TBP CP PMC9606402__F5 Gadd45b in neurologic and neuropsychiatric disorders: An overview BAX GAP43 GADD45B MTOR BDNF PMC85642__F8 Schematic model of cyclin E-associated kinase activity as an integrative convergence point for the regulation of G1/S transition by the “classic” pRb/E2F and the “parallel” Myc-dependent pathways in mammalian cells (thick arrows) CDK2 MYC PMC11201617__F1 Molecular Mechanisms in Tumorigenesis of Hepatocellular Carcinoma and in Target Treatments—An Overview EGF HGF EGFR PMC11201617__F2 Canonical activation of the WNT/Beta-catenin pathway PIG59 APC GSK3B TBX3 GPR49 SP5 CTNNB1 PMC11201617__F3 Molecular Mechanisms in Tumorigenesis of Hepatocellular Carcinoma and in Target Treatments—An Overview SNAI2 BIRC5 BCL2L1 MMP2 MMP9 PMC11201617__F4 Hippo signaling pathway LATS1 LATS2 NF2 PMC11201617__F6 Notch signaling pathway SOX9 DLK2 EGFL7 CCND1 DNER HES1 PMC9533616__F5 lncRNA PVT1: a novel oncogene in multiple cancers NR1i1 TRPS1 STAT3 FOXM1 AGO1 ARL2 SERPINI1 FGFR1 FGF2 PMC9533616__F6 lncRNA PVT1: a novel oncogene in multiple cancers BMI1 CDC2 VEGFC ZEB2 TWIST1 BCLAF1 KIF23 PMC9533616__F8 lncRNA PVT1: a novel oncogene in multiple cancers TSHR HK2 SOX2 TCF2 IGF1R TMBIM6 ERG MEF2C ELF4 REN PTBP1 GREM1 BCL2 PMC2390552__F6 Analysis of Nodal signaling processes in ERK1MO and ERK2MO gene expression profiles SOX17 EGF ACVR2B SMAD1 JUN SMAD2 SMAD4 NODAL FOXG1 UBE2D1 BAMBI FOXH1 NFKB1 PMC2390552__F7 Analysis of FGF signaling processes in ERK1MO and ERK2MO gene expression profiles SOX17 BAD FRS2 MAPKAPK2 NODAL ARAF SHCBP1 SOST SP3 NRAS GRB2 SP9 CREB1 PMC2390552__F8 Analysis of Wnt signaling processes in ERK1MO and ERK2MO gene expression profiles CDX4 SOX17 GATA2 APC GSC NLK RAC3 CTNNB1 PMC2390552__F9 Analysis of BMP signaling processes in ERK1MO and ERK2MO gene expression profiles BAMBI GNB1 BMPR2 SNAI2 ACVR2B FST PCCA NOG BMPER ID3 PMC7283470__F1 Emerging role of PTEN loss in evasion of the immune response to tumours CXCL1 IRF3 PTEN MTOR PMC7028706__F9 Protein–protein interaction network generated for shared miRNA target genes after miRNET analysis ADRBK1 IFNG MAFK ADAM17 TNF ADA PMC5102796__F8 Model showing the relationship between HPV-induced replication stress, activation of the ATR/Chk1/E2F1 signaling pathway, RRM2 accumulation and productive viral replication ATR RRM2 PMC9533616__F3 lncRNA PVT1: a novel oncogene in multiple cancers SEMA4D ANGPTL4 ATG3 ULK1 HK2 VMP1 PYGO2 INCENP SHH HIF1A YAP1 MGMT PMC9533616__F4 lncRNA PVT1: a novel oncogene in multiple cancers MAPK1 BAX COX2 EGFR YBX1 FJX1 VEGFA RUNX2 IRS1 PMC4985245__F1 IL-33 signaling pathway IRAK3 IL33 IRAK2 TRAF6 IRAK4 MYD88 PMC6895267__F9 The proposed working model CHFR NAT10 MORC2 PARP1 PMC8150590__F1 Crosstalk between Interleukin-1B and Type I Interferons Signaling in Autoinflammatory Diseases CGAS NLRP3 IL1B PMC7250673__F1 Bone Cell Communication Factors Provide a New Therapeutic Strategy for Osteoporosis SEMA4D SLIT3 SEMA3A CTHRC1 PMC1774081__F6 Math1 signalling pathway CCK GIP HES1 RAC1 PMC15871__F3 PI3′K signaling modules in mammals and nematodes have implications for cancer PTEN PMC3070611__F3 One experimental result of identified pathways from ovarian expression data CEBPD GRB2 PMC6458848__F3 DEGs clustered in the PPAR signaling pathway LPL UCP1 HEL-S-28 PMC4337546__F7 Schematic diagram showing the cross talk between HCV and miR-373 inhibiting IFN signaling STAT1 STAT2 JAK1 TYK2 PMC3576710__F1 Transmembrane protein UNC93B1 (black spring-like shape) associates with various toll-like receptors (horseshoe-like shapes) in the endoplasmic reticulum to help load them into vesicles coated with COPII for transport to the Golgi TLR3 TLR9 TLR7 PMC7537965__F1 Workflow for drug and vaccine repurposing VMO1 TBX2 PHF20 RNASE6 GPR162 ANKRD65 TGFBI CCL3 PRMT6 RAB31 PTMS LYZ GLRX HEL-S-51e IFNG PRPF6 KSR2 F3 CCL3L3 FCN1 CSF2 EIF4EBP1 IL4 IL1A IL6 TNF CCL24 SF1 FPRL2 IL24 HDAC10 ADRB2 AIF1 LYN BIRC2 CCL20 PMC7307829__F5 Analysis of TLK1 interactome and hypothetical pathway CDC42 CDC2 AURKA UBC TLK1 FYN PXN CDK2 CCNB1 PLK1 CCND1 PMC3070611__F4 One of experimental result from pathways intersection PI3 CEBPD PTEN RHO ZRANB3 HES1 HES5 PMC3070611__F5 The shortest pathway identified by our system CEBPG CEBPD HEL-S-44 PMC7537965__F4 A venn diagram showing overlaps between BCG genetic mimics and key hubs with SARS-CoV-2 and Corona viruses interactomes BRD4 CCL5 NDUFS3 CAMLG CSNK2B GNB1 HMOX1 IGF2R IFNG BCL2L1 PLAT RIPK1 GGH F2RL1 PPIG CIT EIF4B ATF5 NEU1 SIRT5 PABPC1 IL25 HEL-S-277 SCARB1 SIGMAR1 PSEN2 HEL-S-69p RYBP NDUFA5 PMC5902028__F2 TIGIT pathway CD96 CD226 TIGIT FYN APC GRB2 LCK PMC3244904__F4 Eukaryotic Phospholipid Synthesis and Editing.G3P produced by GPDH is converted to PA by sequential acylation reactions regulated by GPAT and LPAAT PGP PSD HEL-S-5 PC INS PMC10874582__F2 Immune-related signalling pathways in mosquitos AGO2 DICER1 DROSHA MYD88 PMC12234771__F4 Comprehensive strain‐identification pathway for the seven UCYN‐A strains, established by the codon aversion motifs of the 40 genes RPE RPIA ARC NR1A2 PMC8583315__F1 WNT/Beta-Catenin Pathway in Soft Tissue Sarcomas: New Therapeutic Opportunities? ROR1 RNF43 PORCN APC GSK3B LRP5 ZNRF3 LRP6 GPR49 CTNNB1 PMC8165552__F1 Mitochondrial NADH pool is involved in hydrogen sulfide signaling and stimulation of aerobic glycolysis GOT2 HEL-S-62p C2 HEL-S-32 ETHE1 MDH2 SQOR PMC8583315__F3 WNT/Beta-Catenin Pathway in Soft Tissue Sarcomas: New Therapeutic Opportunities? ROR1 BCL9 DKK3 RNF43 PORCN APC GSK3B LRP5 ZNRF3 LRP6 GPR49 CTNNB1 PMC6411635__F2 Metabolic reprogramming of T cells after allogeneic stem cell transplantation FAS HK3 HK2 MTOR PMC7492732__F1 Biosynthesis of kinamycin ALPI ALPL AIP PMC2932677__F1 Diversity and Plasticity of Th Cell Types Predicted from Regulatory Network Modelling IL-21 IL2RB APC IL2RA IL2 PMC5983613__F5 Leptin is a very important factor that links fatty acid Beta-oxidation with oocytes maturation HSD17B4 ECHS1 HADHB PIM1 ACADS XPR1 CPT2 ACADM PMC10998350__F5 Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway TERF2 ATM SIRT1 PMC9239034__F1 Expression Profile of Genes Related to the Th17 Pathway in Macrophages Infected by Leishmania major and Leishmania amazonensis: The Use of Gene Regulatory Networks in Modeling This Pathway USP25 STAT1 JUN OSM CCL20 TRAF2 PMC5921304__F6 Metabolic enzymes belonging to the most divergent group (protein sequence identity) in the context of carbohydrate metabolism HEL107 HEL-S-304 TREH PMC6436646__F2 Calcium signaling pathways and their effects on the calcium responsive percentage of chondrocytes CTRL PMC8301219__F3 Immune Checkpoint Inhibitors in Human Glioma Microenvironment TH GAL PMC2787458__F9 Wnt3a stimulates Src docking to, activation by, and phosphorylation of Dvl2 WNT3A LRP5 LRP6 DVL2 SRC CTNNB1 PMC9168090__F9 Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine CAV3 CAV2 HRC PI3 MCU PMC3694614__F9 Free Radical-Producing Myeloid-Derived Regulatory Cells: Potent Activators and Suppressors of Lung Inflammation and Airway Hyperresponsiveness CD80 IL10 CCL22 PMC7655095__F7 The Gb3‐cSrc correlated mutant p53 signaling pathways GEM METTL3 CTNNB1 PMC6955783__F5 RNAseq genes associated with NRF2-mediated oxidative stress response via IPA® JUN HEL-S-107 PMF1 FRK HEL-S-94n FOS FTH1 BACH1 CCT7 FTL GCLC MAF CLPP PMC6955783__F6 Hypothesized pathway and consequences of glutamine uptake in 2 h post METH STR microglia GLS SLC38A7 SLC1A3 SLC38A1 SLC7A11 GPX8 GLUD1 SLC7A6 PIG59 GCLC SLC1A2 HEL-S-64p HEL-S-44 PMC2818736__F1 Colorectal cancer (CRC) stem cell model APC SMAD4 TCF4 CTNNB1 PMC5740974__F3 Cell entry and innate immune response TLR8 IRF3 TLR7 MYD88 PMC3609760__F5 Transcriptional Profiling of Rice Early Response to Magnaporthe oryzae Identified OsWRKYs as Important Regulators in Rice Blast Resistance CAD CS CCR1 PMC3380573__F1 Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment RHEB TSC2 EIF4B IGF1 MTOR DEPTOR IRS1 PMC5629314__F2 Pathway of de novo fatty acid synthesis in C FAT4 FAT1 GLA FAT2 FAT3 PMC5629314__F6 Abbreviated pathway of prenol and sterol lipid synthesis in C COQ4 COQ3 COQ2 COQ6 COQ5 PMC8567165__F5 Proteomic identification of ruminal epithelial protein expression profiles in response to starter feed supplementation in pre-weaned lambs CFL2 PDLIM7 ZYX RPS19 CTH RPS7 ALB CD44 POSTN SYNPO2 STOM PDLIM3 AKAP12 PMC8745585__F1 Homologous Recombination Deficiencies and Hereditary Tumors BRIP1 RAD51D ATR RAD51 BRCA2 XRCC3 RAD51B BARD1 RAD51C BRCA1 COIL CDK2 ATM PALB2 PMC3484431__F9 Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma SHH SMO MMP9 PMC5685659__F7 Diagram showing LMP1 signaling transduction to IRF4 activation IRF4 PMC8226784__F10 Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells RHEB MLST8 TSC2 RICTOR TSC1 PTEN MTOR PMC9135563__F5 Comprehensive Diagnostic Medical System Based on Notch1 Signaling Pathway to Inhibit the Growth of Small-Cell Lung Carcinoma SMS APP PMC7690808__F3 TGFB targeting factors that “lock” NK cell functions CD226 CD69 MTOR TGFBR1 PMC6826509__F4 Influence of high CO2 concentration on hormone and stomatal regulation IPP LOX CS CPD PMC9634419__F4 Human stefin B: from its structure, folding, and aggregation to its function in health and disease GSK3B MTOR DISC1 CTNNB1 PMC6685084__F1 The genetics of human hematopoiesis and its disruption in disease PDC PMC6525355__F1 Metabolic engineering strategies for producing PPD from xylose TH IPP XDH DMD PMC7690808__F1 Transforming growth factorB (TGFB) signalling pathways in tumorigenesis TGFBR2 HEL113 SMAD2 SMAD4 ARHA MTOR TGFBR1 PMC4804493__F3 Death receptor signaling in SIVA FAS TRADD TRAF5 TRAF2 FADD PMC5360883__F1 Diagram summarizing the effects of effector proteins on inflammatory signaling pathways in host cells TRADD NLRP3 RPS3 TLR4 HEL-S-162eP TAB3 GSK3B TRAF6 TRAF2 IL1B MYD88 PMC8848739__F4 Case report of recurrent fibromatosis with laryngeal involvement: Treatment based on network analyses of NGS data ROR1 MUSK MATK CSF2RA DDR1 PPM1M KCNA4 KERA ELAVL3 DDR2 TRIM46 FER CDC37 MDM2 RALBP1 RASA4 PMC9297685__F4 Possible mechanisms of cardioprotection resulting from stimulation of insulin receptor family members CGAS IGF1 ULK1 IGF2 PMC3684860__F7 Evolution of the Eye Transcriptome under Constant Darkness in Sinocyclocheilus Cavefish GUCA1A NRL CRX GNAT1 NR2E3 GNAT2 OTX2 RORB NR1A2 PMC5739070__F3 Optic Pathway Gliomas in Neurofibromatosis Type 1 MTOR SRC RAC1 PMC8785327__F4 Differential target multiplexed spinal cord stimulation programming modulates proteins involved in ion regulation in an animal model of neuropathic pain GABARAP GPHN SLC1A3 PCP4 SLC32A1 SLC6A1 GABRB3 GLRA1 HEL-S-51e NRXN3 GABRA3 GABRB1 SLC4A1 PHGDH GAD2 PSAT1 NLGN3 PMC6693432__F5 Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis C6 CD59 C7 SERPING1 MASP2 FCN3 HEL-S-62p C3AR1 CFD CFH CR2 VTN CS CD55 C4A CR1 MASP1 CFI CFP C2 CLU C9 PMC11822654__F2 Efferocytosis in immune cells GPR132 COX2 CD36 DUSP4 VAV1 PTGS2 MYC RAC1 MERTK PMC7755516__F1 Intestinal epithelial cells (IECs) apoptosis in an acute and chronic state of intestinal diseases TRADD NFKB1 TRAF5 RIPK1 TRAF2 FADD PMC4130902__F1 G-protein—coupled receptors, hedgehog signaling and primary cilia GPR161 SHH PMC9301190__F2 Role and Mechanisms of Tumor-Associated Macrophages in Hematological Malignancies STAT3 CXCL12 EGF CCR2 CD163 CXCR4 CCL2 CD47 CD68 CSF1R PMC4130902__F2 G-protein—coupled receptors, hedgehog signaling and primary cilia EVC2 EVC SUFU SHH SMO EFCAB7 GLI3 PMC12108454__F1 Primary etiological factor for PMOP is estrogen deficiency SOST DKK1 LRP5 LRP6 RUNX2 CTNNB1 PMC12108454__F2 New Perspectives on Postmenopausal Osteoporosis: Mechanisms and Potential Therapeutic Strategies of Sirtuins and Oxidative Stress SIRT3 CTSK NFATC1 RUNX2 SIRT1 SIRT6 PMC12108454__F3 OS leads to the overproduction of ROS SIRT3 GPX4 HEL-S-28 RUNX2 SIRT1 SIRT6 PMC3432093__F11 Resveratrol Inhibits LPS-Induced MAPKs Activation via Activation of the Phosphatidylinositol 3-Kinase Pathway in Murine RAW 264.7 Macrophage Cells COX2 PTEN MTOR SIRT1 IL1B PMC3562715__F2 Oncogenic pathways in ABC-DLBCLThe stimulation of several surface receptors, including the B-cell receptor (BCR), CD40 or Toll-like receptors, triggers signaling cascades resulting in the activation of the NF-kB pathway CD40 CD79B CD79A CARD11 IRF4 BCL6 MYD88 PMC11822654__F3 Impaired efferocytosis in aging CD24 TYRO3 AXL SIRPA CD47 MERTK PMC5350184__F2 Genes involved in adipose tissue TLR‐ and insulin receptor signaling correlated with changes in plasma concentration of fetuin‐A and FFAs TCIRG1 TIRAP NFKB2 IKBKE TAB3 PIK3R1 MAPKAPK3 CTSS CNPY3 IKBKG STRADA PIK3R4 MAP2K4 TICAM1 NOD2 HEL-S-1 SHC3 MAP2K3 CDC2 TICAM2 SIGIRR HRAS MLST8 UNC93B1 TSC1 MAP3K1 TLR3 GRB2 TLR10 PMC5350184__F3 Genes involved in skeletal muscle TLR‐ and insulin receptor signaling related to changes in plasma concentration of fetuin‐A and FFAs PIK3CA MAPK11 SOS1 PIK3R2 IKBKE TAB3 CTSS IRAK4 ATP6V1C1 GRB10 RIPK2 PIK3R4 PDPK1 FGFR4 TLR8 NRAS TLR7 CREB1 MAPK1 EIF4EBP1 TICAM2 EEA1 TLR1 TSC1 PRKAA2 PRKAB2 RPS6KA3 FGF18 PMC10854713__F3 Phosphorylation regulates EMT and other functions of CRC cells STAT3 GOLPH3 ITGA7 STAT2 SPHK1 APC PTEN UBXN2A PPDPF CTNNB1 NR3C2 BCKDK FGFR4 SRC TNIK LHPP PMC7399071__F2 DNA repair pathways RAD51 LIG1 PCNA XPC PMC10854713__F5 Glycosylation regulates the metastasis of CRC cells OGA OGT GAL HEL-S-62p ST3GAL6 FUT2 ST6GAL1 CD82 APC GSK3B EZH2 MTOR CTNNB1 PMC1435944__F6 Graphical Interface for the KnowledgeNet of candidate genes for hypertension PRSS8 PPARG LEP EGFR CRH NR0B2 INS CCL2 ADRB3 GNAS REN MME NPY CYBA NPRC NR1i1 PTGS2 IRS1 NPPA IGF1 ADRB2 EDNRA NPR2 AGTRAP NPPB PMC11475559__F3 RhoA is overexpressed in cancer and promotes cancer progression via RhoA/ROCK2 signaling pathway ROCK2 ARHA CCND1 PMC3124103__F1 Transcription factor NFKB regulates the cellular response to inflammatory and oxidant stress, as well as stretch EGR1 PLG PMC7530265__F9 The potential protective effects of PA in LPS-induced intestinal barrier dysfunction NLRP3 TLR4 IL1B PMC9209463__F3 Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases STAT3 HBEGF PDPK1 CARD11 EGFR FASN ARHA RHO VEGFA RAC1 PMC5828951__F2 Targeting Bromodomain and Extraterminal Proteins in Breast Cancer BRD4 PTEN MTOR PMC3207219__F1 ROCK signaling pathway with focus on survival and regeneration RHEB LPA CNTF TSC2 TSC1 LINGO1 PTEN ARHA PMC9475465__F3 Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy CXCR1 IL8RB PMC9209463__F2 Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases ACLY EBP SCD FASN GSK3B ELOVL1 ACACA ACSS1 MVK INSIG1 HMGCS1 ELOVL3 GPAM DHCR7 FDPS IDI1 FDFT1 PMC7521217__F10 Based on the findings from Figures  and , we summarized the proposed underlying mechanism of oxidative stress downstream signalling pathway participated in brain damage in setting of acute IS BAX C9 ME1 EME1 PMC4569902__F7 Schematic view of the integration of Sema3-Nrp with the Hh signal pathway by controlling PKA and PDE4 SHH SMO PDE4D PMC6765251__F6 Putative metabolic map of a bacterium within the miscellaneous Bacteroidales metagenome reconstructed from the metagenomic data AMT MAL PMC3973656__F1 Curbing autophagy and histone deacetylases to kill cancer cells ATG3 ULK1 PMC12232871__F7 Some KRAS signaling pathways mediating PC mentioned in this review RALB RPIA RALA PEAK1 EGFR EIF5A MTOR SRC MYC KRAS PMC12232871__F8 Some p53, CDKN2A, and SMAD4 signaling pathways mediating PC mentioned in this review FOXA1 CDKN2A CDK6 HEL-S-68p SMAD2 SMAD4 HNRNPK KRAS CREB1 CDK4 PMC6797860__F1 Receptor composition of IL-12 family members and related cytokines STAT3 IDE STAT1 EBI3 STAT4 IL23R IL12RB1 PMC7890593__F3 Identifying AKAPs in Cells and Tissues SF3B1 THRAP3 KIF23 BCLAF1 HNRNPF DIDO1 RBM25 NUP153 CHERP DHX15 SART1 INCENP SART3 SLU7 HCTP4 RBM14 PMC6912721__F6 Urea cycle and nitric oxide pathway ASS1 ASL OTC ARG1 ARG2 PMC8326113__F6 CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways CXCR6 CXCL16 ADAM10 PMC9028856__F1 Autophagy Process in Cervical Carcinogenesis: Role of Non-Coding-RNAs, Molecular Mechanisms, and Therapeutic Targets RHEB RICTOR ATAD3A ATG3 ATG12 ULK1 RPS6KB2 SQSTM1 MTOR ATG5 PMC12232871__F5 Underlying mechanisms of several potential PC therapeutics via proteomic approaches HEL-S-72p BAX TGFA SP1 HEL-S-133P SMAD2 SLC7A11 MMP9 MTOR MMP2 SHH UACA AK4 PMC3155287__F1 Autophagy regulation RHEB MLST8 TSC2 TSC1 RAF1 PTEN MTOR PMC6776600__F1 Overview on complement activation and cascade progression C5AR2 C5AR1 HEL-S-62p CP PMC3268901__F1 The PTEN/mTOR signaling pathway TGFA PTEN MTOR PMC11019658__F3 Mechanisms by which DHM inhibits tumour cell invasion and metastasis CDH2 SP1 PTEN PMC9841179__F5 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases TBK1 CGAS IRF3 OTP PMC1815248__F5 Co-option of a developmental pathway by invasive tumors RECK MMP2 SCRIB PMC11019658__F1 Mechanistically, DHM inhibits tumour cell proliferation STAT3 HMGB1 CXCR4 PMC9841179__F6 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases PMC11019658__F2 DHM induces apoptosis in tumour cells and induces the associated signalling pathway BAX IDE FAS MTOR NOTCH1 PMC5454035__F1 Regulation of autophagy by nutrients and hormones via the mammalian target of rapamycin (mTOR) signaling pathway ATG101 RHEB TSC2 ATR TSC1 ULK1 UVRAG ULK2 IRS1 PMC9406056__F1 Neurotransmitters: Potential Targets in Glioblastoma GAL EGFR NPY PTEN PMC6757296__F2 Exosomes secreted by MM, NSCLC and PCa tumors carry different and abundant contents, which serve a key role in osteoclasts or osteoblasts, resulting in different metastatic lesions EGFR AREG PMC4822806__F3 Molecular mechanisms involved in autophagy and NAFLD.Notes: 1 TSC2 TSC1 PTEN MTOR PMC2063536__F7 ES cell–based model describing the ontogeny of NSCs LIF APAF1 FGF2 PMC4029773__F1 JAK-STAT signaling in adipose tissue function FAS PDK4 PRL PMC9841179__F3 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases TBK1 CGAS IRF3 PMC9841179__F4 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases CDC2 TRIM13 SYK TBK1 TRIM38 CGAS TRIM32 TRIM56 KAT5 RNF5 ULK1 PTPN1 SENP7 RNF26 TTLL6 TTLL4 HDAC3 PPP6C USP14 CLU MUL1 OTUD5 TRIM29 RNF111 PMC10139189__F1 Migration and invasion of GBM cells is related to the inherent capacity and the cellular interactions that occur on the migratory front CDH2 CD44 TH CX3CR1 LIF SOX2 GSC WNT3 ANGPT2 CXCR4 PMC7481416__F3 Different pathways in cancer targeted by p-PROTAC APC TCF4 CTNNB1 PMC6539103__F2 Potential roles of aberrant activations of MAPK and PI3K signaling pathways in pathogenesis of PWS/SWS GIP PTEN MTOR SRC PMC2900889__F8 Possible fates of disulfide reduced SOD1 in the G93A/CCS mouse CCS CS HEL-S-44 PMC2966065__F1 Chemical structure of OHyW in tRNAPhe and its biosynthetic pathway TYW5 GC TYW3 TYW1 PMC6915928__F2 The results of protein-protein interactions were identified with STRING database GRAP2 CD48 LY9 TSHR CD27 ARHGAP15 ACAP1 PTPRC BLNK CD40LG PRKCB LTB CYTIP APOBEC3H ICOS LGALS2 CSF2RB MHC2TA CD37 WAS ITK CD3G TLR10 CD3E PMC5658094__F6 Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury TLR4 MYD88 PMC4593030__F7 Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway TXN NFE2L2 PPARGC1A SETD7 PMC8070205__F5 Activation of canonical STING Pathway upon replication stress or DNA damage TBK1 CGAS RAD51 BRCA1 ATM IRF3 TREX1 PMC7593846__F7 Signaling pathway analysis based on the potential biomarkers (A) Summary of ingenuity pathway analysis with MetaboAnalyst NR1i1 PTH IMPACT PMC8070205__F2 Homologous-directed repair RAD51 RMI2 DNA2 BRCA1 WRN BRCA2 GC GEN1 PALB2 BLM SLX4 RMI1 PMC6689035__F7 Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells LAMP2 PRMT6 ATF4 OPTN PMC8637646__F2 Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle SLC38A1 PTEN SLC7A5 TIGAR MTOR MYC NRF1 HEL-S-26 PMC7017004__F1 Signal transducers and activators of transcription (STAT)3 and STAT5 signaling in epithelial ovarian cancer (EOC) and tumor microenvironment LIF PTPRT PMC8070205__F8 Progerin expression in HGPS leads to DNA repair defect, replicative stress, and inflammation through DNA sensing in the cytosol STAT1 RAD50 CGAS RAD51 MRE11A PCNA BRCA1 RIF1 PMC6387042__F1 Mammalian or mechanistic target of rapamycin (mTOR) complexes and signaling pathway of mTORC1 and mTORC2 RHEB STAT3 TSC2 EIF4B GRB10 TTI1 PTEN DEPTOR ELF3 EIF4E PMC7755516__F2 Lytic cell death pathways of intestinal epithelial cells (IECs) during the intestinal diseases RIPK3 GSDMD NLRP3 MLKL GPX4 RIPK1 TNF IL1B FADD PMC2754932__F6 Model of Udu function in DNA damage response MCM3 ATM PMC8228377__F1 Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses COA3 ELOC PMC7027041__F8 Signaling pathways under heat stress affecting bGCs functions: A network map of pathways significantly (P < 0.05) enriched after heat stress PCNA NFKB2 RFXANK PLK1 GNPTAB RAC3 RPS11 MRPL23 MRPL36 HSPD1 MRPL15 MRPL33 CCND2 CCNG2 SUMF1 PLA2G15 HEL-S-11 GHR AMACR HSP90AB1 BAX STAR RPLP0 CTSL FOS GNG2 HRAS HDAC1 RPL15 RPS26 TSC2 GSTA3 RPS24 HEL-S-125m BCAP31 SCARB1 CYP11A1 FOXO3A CASP3 RPRM RRAS EDEM2 PRKAB1 NFYC RNF186 HEL-S-64p TRAF2 HEL-75 PMC6044348__F1 Schematic illustrating the current working hypothesis on IFNT signaling in endometrial epithelia and stroma of the ovine uterus HEL-S-2 STAT2 IRF9 IGFBP1 IFIH1 CTSL IRF1 HSD11B1 B2M RSAD2 PTGS2 SLC7A2 STAT1 IRF2 CST6 ISG15 JAK1 TYK2 PMC8205988__F1 Anti- or pro-tumorigenic function of adiponectin in colon cancer ADIPOR1 ADIPOR2 CXCL1 MTOR PMC9669913__F6 Eupatilin attenuates the senescence of nucleus pulposus cells and mitigates intervertebral disc degeneration via inhibition of the MAPK/NFKB signaling pathway SOX9 TNF COL2A1 PMC8415555__F9 Effect of tonB Gene on the Virulence of Pseudomonas plecoglossicida and the Immune Response of Epinephelus coioides HEL-S-99n FH CAD HEL-S-130P CS TNF PMC9298504__F1 Targeting Macroautophagy as a Therapeutic Opportunity to Treat Parkinson’s Disease GLP1R PINK1 SYNJ1 ULK1 MTOR ATG3 NLRP3 AKT1S1 ATG5 ULK2 RPTOR ATG16L1 LRRK2 UVRAG SNCA DNAJC6 DEPTOR ATG101 RHEB MLST8 ATG10 VPS35 TSC2 TSC1 ATG12 AMBRA1 BCL2 GIPR PMC7136955__F1 Cancer‐associated fibroblasts: activin A adds another string to their bow SMAD2 SMAD4 PMC4183996__F4 Involvement of microRNAs (miRNAs) in epithelial-mesenchymal transition (EMT)-related metastasis CDH2 EGF HGF SMAD2 GSK3B PTEN ZEB2 ARHA CTNNB1 PMC7408135__F2 Ether phospholipid synthesis pathway in peroxisomes GNPAT FAR1 HEL-S-26 PMC8372757__F4 Differential regulation of cerebral microvascular transcription by single and repetitive hypoxic conditioning SYK CDKN1A IRAK2 GRB2 ANGPT2 SRC TRAF6 PMC8372757__F5 Differential regulation of cerebral microvascular transcription by single and repetitive hypoxic conditioning TH SYK CD81 CD80 BAD APC CD22 PTEN CD19 MTOR IFNG NLRP3 CDKN1A BCR DPP4 ALOX12 GRB2 PMC6160013__F8 Anti-oxidant activity of GPx3 mediating lung cancer suppression EGF EGFR GPX3 CCNB1 PMC7761761__F8 Putative metabolic pathway for the production of derivatives of nitrogen-containing azaphilone red pigments in the marine-derived Talaromyces sp CA4 H1-5 GHB3 PMC5218767__F1 Defective Treg cell suppressive mechanisms in IPEX and IPEX-like disorders CD80 APC LRBA CTLA4 FOXP3 PMC11978843__F6 Analysis of DEGs related to energy metabolism, phytohormone synthesis, and signaling pathway MAX CAD F5 F2 F3 PMC6727143__F3 Ingenuity pathway analysis representation of the most significant pathway in ICH versus CTRL – T cell receptor signaling TEC FYN SHB CSK ITK CTLA4 GRB2 LCK PMC6999830__F1 Mitochondria as a regulator of inflammation TFAM MAVS NLRP3 TANK IRF3 TRAF6 IL1B PMC7503245__F8 Schematic presentation of the possible role of bone kynurenic pathway activation in the osteoblast maturation process BGLAP SOST ATF4 CCND1 PMC8636667__F4 Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone FYN FRS2 GRB2 PDK2 SHE PMC8658259__F4 Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area STAT3 ATF3 EGF TSC2 TSC1 IGF1 GHRH MTOR PMC8636667__F1 Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone SI NFATC1 TRAF6 PMC8392326__F2 Inborn Errors in the LRR Domain of Nod2 and Their Potential Consequences on the Function of the Receptor CD80 MAVS NOD2 IRF3 TRAF3 PMC7460564__F3 Enzymatic activity of prolidase affects various cellular processes MTOR PRODH PYCR2 PMC4595774__F1 Regulation of the Golgi via the GOLPH3 pathway GOLPH3 MAJN GOLPH3L PMC1356334__F7 Alignment of sequences adjacent to Y200 for human TRPV1–4 NGF TRPV1 SRC PMC3676171__F2 Bile acid synthesis, conjugation, and biotransformation BAAT CYP7B1 CYP3A4 CYP27A1 PMC7851184__F2 Proposed mechanisms of neoplastic transformation of small intestinal ILCs in refractory CD II IL15 PCNA FOXP3 NOTCH1 PMC7312214__F1 Innovative Potential of Statins in Cancer: New Targets for New Therapies BAX IPP SUFU SHH BCL2 PTEN RHO MMP9 MTOR MYC CCND1 CDK4 PMC6193418__F1 Cell‐intrinsic pathway of apoptosis BAX BCL2 APAF1 PMC3356019__F1 Emerging pharmacological strategies for CSCs targeting include self-renewal pathway antagonists and chemoresistance-reverting agents PTCH1 SMO CTNNB1 PMC6598962__F6 Cooperation of 17-aminogeldanamycin (AG) and trametinib (TRA) or vemurafenib (PLX) a A schematic summary of molecular effects of TRA, and PLX activity, and 17-aminogeldanamycin-mediated HSP90 inhibition in melanoma cells BRAF EIF2D ATF4 EIF2A XBP1 PMC4404315__F3 Embryonic Stem Cell Self-Renewal IL20RB OSM IL21R IL11RA CSF3R IFNGR2 EPOR OSMR IL11 SRC GHR CRLF2 IFNGR1 PIM1 IRF9 LEPR LIF IL20RA PTPN6 PIAS2 CLCF1 CNTF CTF1 IFNAR2 IFNAR1 PIAS1 CREBBP EP300 CISH STAM2 PMC6078129__F1 Programmed cell death: the battlefield between the host and alpha-herpesviruses and a potential avenue for cancer treatment BAX FAS PAF1 TRADD FADD PMC6078129__F2 Programmed cell death: the battlefield between the host and alpha-herpesviruses and a potential avenue for cancer treatment BAX FAS MLKL FADD PMC12038969__F4 Correlation between PYGO2 and IL10 expression through the Wnt/Beta-catenin signaling pathway in ESCC progression IL10 EGFR PYGO2 APC CCND1 CTNNB1 PMC4404315__F2 Embryonic Stem Cell Self-Renewal FGFR4 FGFR1 FGFR3 FGFRL1 SRC FGFR2 PMC2679749__F3 Control of autophagy E2F4 FOXO3A MTOR EIF2A PMC7887427__F7 Differential gene expression of EGFR pathway proteins in TPC1-deficient MEF cells compared with wild-type cellsColor code indicates gradual changes in expression CDC42 STAT3 CAMK1 RAF1 SHC1 PIK3R5 SOS1 EGFR IKBKE PIK3R1 RHO MTOR CTNNB1 STAT1 PIK3C2B MAP2K4 MUC1 NRAS MDM2 SRC NCK1 VAV1 KRAS RAC1 HRAS CBL MAP3K1 CAMK2D PAK1 RPS6KB1 JAK1 GRB2 CAMK2G PMC1502426__F1 Chromophore regeneration in vertebrate and invertebrate photoreceptors RPE LRAT RPE65 PMC3469471__F2 Regulation of the human TRAIL gene BAX FADD PMC2926258__F3 Schematic representation of the role of T cells in the mechanism by which intermittent PTH treatment stimulates bone formation WNT10B LRP4 LRP5 LRP6 PTH PMC3355932__F2 Anaplastic lymphoma kinase signaling BAD ALK JAK3 GSK3B MTOR SRC FOS PMC2850388__F7 Dkk4 and Eda Regulate Distinctive Developmental Mechanisms for Subtypes of Mouse Hair DKK4 DKK1 SOX2 SHH SOX18 DKK2 LEF1 TNLG7C CTNNB1 PMC11761272__F6 Protective effect of HDH against IAV via activation of the innate immune system ISG20 SIRT3 STAT1 CGAS STAT2 IFNAR2 IRF9 IFNAR1 IRF3 JAK1 TYK2 PMC8972670__F1 Characteristics of NLRs NLRP1 NLRP3 NLRP10 NOD2 TNF PMC6314075__F2 Nuclear factor of activated T cell (NFAT)c1-centered osteoclastogenic signaling network TEC DCSTAMP SYK BTK SEMA3A SEMA6D SIRPB1 NRP1 OSCAR NFATC1 TRAF6 PMC4019002__F1 Omega-3 fatty acids and dementia IDE BAD IGF1 INSR PDK2 PMC12116884__F9 PF ameliorates neuroinflammation induced by ABO SYP ARG1 BDNF CD68 PMC8870839__F2 Iron in Porphyrias: Friend or Foe? CPOX AIP ALAS1 ALAS2 UROD UROS PMC9126665__F10 Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NFKB Signaling Pathway GSTM1 KEAP1 GCLM TLR4 AMELY TNF MYD88 PMC5398616__F3 Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle TRRAP ZBTB33 ARPP-21 YWHAG PMC3478427__F2 Metabolic Actions of Angiotensin II and Insulin: A Microvascular Endothelial Balancing Act DHFR ARHA PMC4178426__F9 Vascular smooth muscle contraction pathway LAT REL RET PMC3478427__F3 Metabolic Actions of Angiotensin II and Insulin: A Microvascular Endothelial Balancing Act GRB2 PMC4178426__F6 Cell cycle pathway MAL ELL HEL-S-11 PMC3564914__F1 Transcriptome analysis of bitter acid biosynthesis and precursor pathways in hop (Humulus lupulus) IPP BCAT2 BCAT1 PMC5536301__F7 Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis HEL-S-304 H6PD GCLC HEL-S-64p PMC5955138__F1 Natural product based sensitization of GBM BAD FOXO1 PTEN MDM2 MGMT PMC7533754__F1 Mechanisms involved in gut microbiota-host communication NLRP3 FOXP3 PMC10150895__F2 Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers CDH2 CXCR6 CCND2 GC MTOR VEGFA TWIST1 SOX4 CTNNB1 PMC8669998__F1 Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature TBK1 MAVS STAT2 IRF9 TLR9 IRF3 IRF7 TRAF3 TRAF6 MYD88 STAT1 TLR3 IFNAR2 TLR4 IFNAR1 TLR8 TLR7 JAK1 TYK2 PMC4745742__F8 Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activation DPT ARHA RHO PMC8860897__F1 Immune Checkpoint Inhibitors in Tumors Harboring Homologous Recombination Deficiency: Challenges in Attaining Efficacy STAT3 STAT1 IRF1 SIRPA IRF3 CD47 PMC12041090__F3 Mechanisms by which natural products ameliorate renal fibrosis TBK1 CGAS ZDHHC1 ULK1 JAK3 SMAD2 SMAD4 PTEN CTNNB1 SIRT3 ZBP1 TLR4 LRP5 LRP6 ALG3 IRF3 IRF7 DEPTOR RAC1 ZDHHC11 TSC2 TSC1 AMBRA1 BCL2 CCL4 JAK1 SIRT1 PMC8589249__F1 CCR7 in Blood Cancers – Review of Its Pathophysiological Roles and the Potential as a Therapeutic Target SYK BTK CCL19 CCL21 PLCG2 CCR7 PMC6438423__F4 Analysis of the PI3K/AKT signaling pathway based on the KEGG database RPS6 EIF4B RAF1 MCL1 RBL2 PTEN MTOR MYC PCK2 TSC2 HEL-S-1 MAP2K1 CDC37 MDM2 CCND1 PMC12041090__F2 TGFB/Smads signaling pathway STAT3 STAT1 SMURF1 SMAD2 APC JAK3 SMAD4 NODAL MTOR JAK1 SMURF2 CTNNB1 PMC11035622__F8 Mitochondrial enzyme FAHD1 reduces ROS in osteosarcoma ACLY GLS SLC25A51 MAL SLC25A1 PC HP CIT PMC6679203__F1 Signaling in AML FLT3-ITD FLT3 SYK BAD GRB2 MTOR EIF4E PMC8901701__F1 Immunopathology and Immunotherapy of Inflammatory Skin Diseases STAT3 CXCL1 CCR6 CXCL8 CCL20 IL23R TYK2 PMC3942542__F1 Cyclic adenosine diphosphate ribose mediated Ca2+signaling TRPM2 STIM1 PMC6948255__F6 Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1 MMP3 CCND1 SFRP1 CTNNB1 PMC5877599__F4 Wnt and other signaling pathways regulating pluripotency of stem cells STAT3 TH SKIL REST ROCK2 LIF DUSP9 SOX2 NODAL ARHA POR BAMBI TCF3 SOST INVS BMP4 LEFTY2 CER1 NLK TEF HES1 PMC5877599__F5 Hippo signaling pathway NKD1 RASSF6 SMAD1 ID2 PATJ SMAD2 SMAD4 AREG AXIN2 LATS1 LATS2 AFP AMOT SCRIB PMC8692906__F2 Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization STAG2 DBF4 CD2 CDC20 PCNA STAG1 ORC6 SMAD2 SMC3 MAL SMAD4 CYC1 PLK1 ORC3 SKP2 ORC2 LIG1 CDK7 DNA2 CDC45 CDK2 MDM2 MCM2 CD6 PMC6863919__F5 Metabolic reconstruction of “Ca IPP PDC PMC5992490__F2 Actions of IGF-1 and angiotensin II in skeletal muscle BAD IGF1 IGF1R PMC7327986__F5 NRF2 signaling pathway in the context of environmental pollutants induced redox toxicity and its regulation KEAP1 EGFR HSF1 PTEN PMC4394695__F1 Nuclear distribution of the PI3K pathway AKT3 IPMK PTEN PMC3704172__F3 miR-181b and miR-146a induced in CAFs are involved in the regulation of the NFKB signaling pathway STAT3 IRAK1 TRAF6 PMC6428526__F3 EMT is Modulated by Multiple Cascades Through Several Networks CDH2 SETD1A SIRT1 PMC8979689__F6 Folecitin Isolated from Hypericum oblongifolium Exerts Neuroprotection against Lipopolysaccharide-Induced Neuronal Synapse and Memory Dysfunction via p-AKT/Nrf-2/HO-1 Signalling Pathway BAX SYP BACE1 PMC8330071__F8 TLR7/8 signalling affects X-sperm motility via the GSK3 A/Beta-hexokinase pathway for the efficient production of sexed dairy goat embryos GSK3A GSK3B TLR8 TRAF6 PMC2848307__F1 Survival pathways with their cross-talk and immune regulatory mechanisms are shown in this pictorial representation of the Reed-Sternberg (R-S) cell CD40 STAT3 CDA IL6 MTOR SRC MYC PMC4086757__F1 Classification of resistance mechanisms to BRAF inhibitors BRAF NRAS PTEN IGF1R MTOR CDK4 PMC4281955__F1 Telling the story of a gastric cancer through sequencing and functional studies CDH2 TGFBR2 CDH4 FGFR2 PMC3659509__F1 Intracellular effects of soluble mediators are mainly mediated through the interaction with specific receptors that link extracellular signals up to modulation of gene expression NR1C1 FOXO1 MAFA EGFR PMC2912204__F1 PIK3CA and KRAS mutations predict for response to everolimus therapy: now that’s RAD001 RHEB TSC2 TSC1 PTEN MTOR PMC6830079__F1 Cyclic GMP AMP synthase-STING (cGAS-STING) pathway signaling as activated by genomic instability TBK1 CGAS RELA RELB IRF3 PMC6830079__F3 Two faces of cGAS-STING signaling in cancer STAT3 STAT1 CGAS APC CXCL10 CCL2 TNF PMC7057487__F3 Conceptualized network for the 7 enriched neurotransmission pathways MAPK1 SLC17A6 GRIA2 CACNA1C SCN7A ATP2B4 SCN1A GSK3B GAD1 BRAF PLCL1 SLC6A1 PPP2CA MAPK9 GRIK2 GNB1 GRIK3 DLGAP1 KCNQ3 ADCY9 CACNA2D1 MAPK10 SLC1A1 PMC4652019__F1 TLR4 signaling in obesity RAB8A TLR4 MYD88 PMC6086983__F4 Scheme of the mechanism by which pioglitazone (PIO) regulates hepatic metabolites, lipids and related gene‐expression patterns (italicized) TG FAS CD36 DGAT2 LPCAT3 HEL-S-5 PC ACD PMC7956931__F2 Simplified overview of EGFR pathway, with numbers of studies included per EGFR pathway inhibitor target EGFR BRAF PTEN MTOR PMC2787898__F1 TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in mice TIRAP TLR4 IRF3 TRAF6 MYD88 PMC11870265__F5 MAPK signaling pathways, their activators, and inhibitorsrelevant to this study EGF EGFR PMC7363118__F12 RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination TBK1 MAVS TRIM25 IRF3 PMC11911240__F4 Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy PRMT1 TBK1 TRIM38 CGAS PALM DDOST HAT1 PTMS IRF3 TRIM29 PMC1483149__F1 Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony FAS PC MTOR PMC11911240__F1 CGAS-STING-TBK1 signaling pathway TBK1 CGAS RELA RELB IRF3 PMC12116456__F3 VEGF-A/VEGFR2 axis drives HB pathogenesis via angiogenesis stimulation MTOR VEGFA SRC PMC8714735__F3 IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma EPCAM STAT3 CD24 AFP SRC CXCR4 PMC11276702__F7 Gene expression of plant hormone biosynthesis pathway in the intraspecific hybrid fruit of H LOX SI DAO PMC8956559__F4 Adipose tissue: a neglected organ in the response to severe trauma? TF HMGB1 CFD UCP1 TNF IL1B PMC8637576__F6 Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes IFNG CERK HGF IL2 PMC2614485__F6 A simplified Hh signaling pathway, constructed from combined Drosophila and mammalian data SMO GAS1 SKI PMC7913072__F4 Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases BAX BAD TGFB1 SMAD2 SMAD4 TNF CTNNB1 FADD PMC4707055__F2 CO2 sensing and CO2 regulation of stomatal conductance: advances and open questions CA4 HEL-S-11 PMC8571860__F6 Wheat transcriptome profiling reveals abscisic and gibberellic acid treatments regulate early-stage phytohormone defense signaling, cell wall fortification, and metabolic switches following Fusarium graminearum-challenge BIN2 HMGCR BAK1 PMC2797318__F2 Promising bone-related targets for rheumatoid arthritis therapy SMAD1 DKK1 APC LRP5 SMAD4 LRP6 LEF1 CTNNB1 PMC11064406__F3 Intracellular copper distribution pathways ATOX1 CCS ATP7B COX17 HEL-S-44 ATP7A PMC10609905__F1 Vitamin D synthesis pathway NR1i1 CYP27B1 CYP24A1 MYH1 FGF2 PMC10604974__F3 Activation mechanism of the NLRP3 inflammasome GSDMD MAVS NLRP3 TNF MYD88 PMC10604974__F2 Autophagy in viral infection ATG101 ATG10 ATG3 ATG12 ULK1 AMBRA1 ATG14 MTOR ATG5 ULK2 PMC3889557__F10 Schematic representation of eHsp90A signaling pathway PMC9699419__F2 Cluster C19MC in Pre-Eclampsia Development FOXL2 NLRP3 TNFAIP3 DIPLA1 MMP2 CXCL6 PMC7880238__F1 Key signals regulating YAP/TAZ activity HEL-S-31 TAOK1 TAOK2 MAP4K3 MAP4K1 MAP4K2 RHO TEAD4 LATS1 LATS2 TEAD2 TEAD3 AMOT TAOK3 NF2 SRC PMC6685594__F4 lncRNAs mediate drug and radiation resistance STAT3 BAX HOXA1 TGFA SOX9 ULK1 EGFR MCL1 IGF1R MTOR CTNNB1 PMC7786191__F2 UPRER and UPRmt mechanistic commonalities and differences are described in this figure ATF5 CLPP EIF2A XBP1 PMC7880238__F2 Proposed strategies and small molecules (direct and indirect) that could promote or inhibit YAP/TAZ activity LATS1 HEL-S-31 MAPK4 CA3 LATS2 MAP4K3 MAP4K1 AMOT MAP4K2 ARHA SRC VGLL4 PMC11095602__F2 Senescence-associated lymphoma progression and drug resistance STAT3 BTK JAK3 SOX2 EZH2 MTOR MYC GATA4 MYD88 PMC5296610__F4 Most significantly relevant pathways and highly linked molecules relevant to the merged bionetwork NNMT FAS CNR2 ESPN CP PMC6033972__F2 Canonical and non-canonical signaling of interferon-gamma IFNG STAT3 RAF1 CRKL RAC1 RUNX3 PMC9062079__F2 Lens Aquaporins in Health and Disease: Location is Everything! TRPV1 OSR1 PMC4700229__F1 Interactions between immunotherapy and targeted therapy EGFR APC GRB2 MTOR PMC9076866__F8 Mechanism by which Grem1 regulates the TGFB1/Smad2/3 signaling pathway in IVDD SMAD2 GREM1 SMAD4 PMC9610147__F1 Innate immune responses by rabies virus TBK1 STAT1 STAT2 IRF9 IRF2 PML IRF1 IRF3 IRF7 TYK2 PMC5479833__F4 Current model for selective compound families to promote neuronal compensation in HD via a stress response system centered onto FOXO and its co-factors CDC2 NR1H3 OSM PLK2 GSK3B POP1 CTNNB1 CDK8 TPH1 KEL FBP1 MEI1 SOX3 UBXN4 JAK1 SIRT1 PMC8391764__F2 Platelets, Not an Insignificant Player in Development of Allergic Asthma TSLP CD69 IL33 MMP2 AHR MMP9 BDNF PF4 PMC4117150__F3 The Sonic Hedghehog (Shh) signalling pathway: Activation of signalling pathway is connected to various transmembrane proteins (Ptc, Smo), transcription factors (Ci/Gli) and protein kinases (Su(fu), fu) (Reproduced with permissions from Reference 31) SUFU SHH SMO PMC11064406__F4 Molecular mechanisms of cuproptosis DLAT LIAS FDX1 ATP7B COX17 ATP7A PMC2712626__F1 The Double Life of Irs TG FOXO1 FOXA2 IRS1 PMC9556833__F4 Ubiquitin-like processing of TUG proteins as a mechanism to regulate glucose uptake and energy metabolism in fat and muscle CRK HEL-S-61 APOE ATE1 SH2B2 TBC1D4 APOA5 IRS1 PMC3376640__F6 Proposed Model of Psoriasis Pathogenesis in the Presence of Psoriasis-Specific CARD14 AlterationsAfter an inflammatory trigger, alterations in CARD14 induce activation of NF-kB CARD14 IF2B1 IL36RN TRAF3 TNF CCL20 TRAF2 PMC9519816__F2 Exploring the role of Nrf2 signaling in glioblastoma multiforme JUN KEAP1 NQO1 GSK3B MAF PMC3711071__F1 Function and regulation of AMPK leading to tumor suppression TSC2 TSC1 ULK1 MTOR ULK2 XPC PMC6960354__F1 Kynurenine pathway of tryptophan metabolism IFNG KYNU KMO PMC12111917__F7 Signaling pathways activated by exogenous sVASN treatment in different cell types STAT3 LAMA5 SMAD1 PKN1 PATJ EGFR PLA2G4C EFNA1 WNT10A MAPK3 FGFR2 BCL2L1 WWTR1 LLGL2 ITGB8 TEAD3 INSR AMOT OSMR PDGFC ITGA2 FGFR1 MAML2 HES1 CREB1 CSF1R EFNA5 YAP1 HDAC1 PARD3 NFKB1 WWC1 IKBKB ATXN1 IFNAR1 LAMA4 CTNNA1 ITGB5 PMC7310537__F6 Phosphorylation of HH pathway components after 15 min treatment PSMD4 PSMD11 MTOR IFT140 IFT172 PSMD1 ADRBK1 EVC SAG ADCY3 SUFU PRKCA SMO INPP5E PMC3149747__F2 Extensive feedback and feedforward loops between Ras signaling and miRNAs SPRY2 RREB1 BTG2 RHOB TNFSF6 MYC APAF1 SPRY1 IRS1 PMC3553295__F3 Cocaine and Withdrawal on the Mouse Nucleus Accumbens Transcriptome RAP1GAP CREBBP PMC11657697__F2 Inflammasomes in the three stages of HSCT Mobilization HMGB1 GSDMD VCAM1 CXCR4 S100A9 PMC11657697__F3 Correlation between inflammasomes and HSCT TH HEL-S-92n FAS PMC4777846__F7 Schematic diagram of LRP1/Wnt5a-dependent inhibition of intracellular cholesterol accumulation NCEH1 ABCG1 ABCA1 PMC11657697__F1 Inflammasomes are multiprotein complexes composed of several domains with distinct functions NLRC4 NLRP1 HMGB1 GSDMD NLRP6 NLRP3 AIM2 RHO S100A9 PMC6763609__F11 DEGs are potentially related to Alzheimer’s relevant pathways and functions PCP4 SERPINA3 SCN1A HAPLN1 GDA THOP1 MME DKK1 NTRK1 ALDH1A2 TNFSF10 DLX4 C7orf16 PMC6373781__F8 The interactions involved in the alteration of DC function following exposure to F CD83 UNK PMC2994781__F1 Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis TF TH DHPS PMC11704410__F7 The function of Tanshinone in androgenetic alopecia DUOXA2 GPRC6A DUOXA1 DUOX1 DUOX2 PMC3749718__F7 The putative steps in the redox signaling pathway leading to adaptive activation of transcription factors and upregulation of the expression of cytoprotective proteins following contractile activity in skeletal muscle TF HSF1 PRX PMC4946323__F7 Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy BAX ATR CDK6 CDK2 MDM2 CCND1 CDK4 PMC8139422__F7 SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation STAT1 HEL-S-62p C1S C1R RELA CD46 ACE2 PMC7249691__F8 Schematic diagram illustrating the different in canonical versus non-canonical response to IL-12 STAT4 TYK2 IL12RB1 PMC11281156__F6 Proposed cellular signal transduction pathway of TCBPA-induced cell inflammation in Jurkat cells MAPK1 GPER IL2 IL17A IL1A IL6 MAPK8 TNF GPX1 HEL-S-44 MAPK6 MAPK3 PMC2675004__F1 Crosstalk via the NFKB Signaling System CD40 LTA FAS LTBR TNF PMC10975890__F1 MAPK signaling pathway (KEGG: 04010) enriched in bovine fibroblasts infected with B MAX EGF JUND TRADD CD14 TNF TRAF6 FLNA MEF2C NF1 NLK GRB2 TRAF2 PMC11917101__F11 Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/Beta-catenin/TCF4 signaling in sepsis-associated encephalopathy TCF4 WNT3 CTNNB1 MPO PMC3254631__F5 MiRNA Expression by Dietary Polyphenols in apoE Deficient Mice: A New Mechanism of the Action of Polyphenols GNG2 CRK EGF FGD1 PXN APC CD14 LBP PMC5240216__F3 IRE1ɑ-XBP1 is one of the arms of UPR that polarizes tumor-infiltrating myeloid cells into highly immunosuppressive populations STAT3 XBP1 PMC9632420__F7 Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel’s activity by suppressing the NF-kB signaling pathway CDH2 EGFR PMC8899708__F5 New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology CD40 MAP3K8 MMP3 PMC8150754__F2 Therapeutic Strategies for Metastatic Triple-Negative Breast Cancers: From Negative to Positive APC PTEN HIF1A CTLA4 MTOR MYC PMC3690345__F2 Metabolic crossroads of iron and copper ATOX1 TFR2 FXN CCS STEAP3 FES HP ATP7B COX17 HEL-S-44 ATP7A CP PMC10241773__F2 Epigenetic regulation and therapeutic targets in the tumor microenvironment CD40 CXCL9 METTL4 CD80 S100A8 EZH2 ARG1 YTHDF1 CXCL10 CCL2 CCR7 HDAC11 METTL3 USP24 CCR8 HDAC6 PMC8379496__AF1 Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation CDC2 PCK2 CCNB1 CCND1 CDK4 PMC8466180__F2 Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future STAT3 SLC3A2 IPP TYRO3 HMGCR GPX4 GSK3B SLC7A11 MDM2 HEL-S-64p DHODH PMC10383069__F2 Understanding the Roles of Very-Long-Chain Polyunsaturated Fatty Acids (VLC-PUFAs) in Eye Health ELOVL4 ELOVL3 ELOVL2 ELOVL1 ELOVL5 PMC3159521__F2 Pre-B-cell-receptor signaling is regulated by a feed-back loop via Ikaros and Aiolos FLT3 BCR PMC5504126__F2 Cholesterol synthesis and metabolism in astrocytes and neurons APOE LDLR CYP46A1 PMC7578258__F2 Metabolic rewiring and redox adaptation induced by BRAFi during melanoma progression BRAF PMC7033114__F8 IDO1 and TDO contributing to the malignancy of gliomas AQP4 IDO1 AHR PMC9339493__F6 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) STAT3 SRC CTNNB1 PMC9339493__F2 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) STAT3 FZD2 COX2 APC WNT1 CTNNB1 PMC2817017__F2 RAS-RAF-MEK-ERK signaling pathway GRB2 GAB2 PMC8537916__F2 Mitochondrial Contributions to Hematopoietic Stem Cell Aging SIRT3 SIRT7 NLRP3 WAS MTOR IL1B PMC7691524__F7 RA Metabolic pathways affected by DEAB and TTNPB treatments CYP26B1 AOX1 RBP4 RDH10 ALDH1A2 RGR RETSAT CYP26A1 DHRS3 PMC9339493__F4 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) STAT3 INPP4A CBX3 PMC4133096__F2 Role of 53BP1 during the cell cycle BRCA1 ATM RIF1 PMC9339493__F5 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) STAT3 PMC6421044__F3 Regulatory loop among Kaiso, Wnt11/5a and Suz12 SUZ12 PMC2905064__F2 Integration of oncogenic and tumor suppressor inputs by the GLI code in cancer JUN REN PTCH1 NUMB PTEN MDM2 PMC5648021__F2 Metabolic Instruction of Immunity OPA1 MTOR CPT1A PMC8666286__F9 CoCrMo‐Nanoparticles induced peri‐implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2‐ARE signalling pathway SLC3A2 GPX4 SLC7A11 PMC9433910__F3 Progress in preclinical studies of macrophage autophagy in the regulation of ALI/ARDS MAPK1 NLRP3 MTOR MAPK8 PMC2848014__F8 Proteomics Reveals Novel Oxidative and Glycolytic Mechanisms in Type 1 Diabetic Patients' Skin Which Are Normalized by Kidney-Pancreas Transplantation NR1C1 HEL-S-102 OTP PMC6639367__F1 Cellular glycolysis and oxidative phosphorylation TES F2 PMC7669588__F2 Pathway for Nucleotide Excision Repair (NER) XPA PCNA XPC PMC7186465__F1 Anticipated mechanism of action of IL-17B in tumorigenesis TFF1 GSK3B TRAF6 PMC4535882__F7 Multiple Protein Kinases via Activation of Transcription Factors NFKB, AP-1 and C/EBPD Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes EBP AKT3 PMC8353216__F2 COVID-19 pandemic: insights into molecular mechanisms leading to sex-based differences in patient outcomes TMPRSS2 ACE2 PMC3932224__F3 Summary of regulatory networks centered by typical 2-Cys Prxs BAX ABRA PGR CYCS EPO PTEN MIF HEL-S-97n MYC TXN BTK HEL-S-2a HEL-S-69p NOD2 CDK2 APP PMC10523190__F1 Progress in the research of cuproptosis and possible targets for cancer therapy PDHA1 DLAT MTF1 HEL-S-5 DLD FDX1 ATP7B ATP7A PMC11852824__F10 Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth BAX BAD BRAF NRAS FOS PMC8080560__F2 Depiction of key proteins targeted by CRLs during cell cycle progression CDC2 FOXM1 CDK6 CDK2 CDK4 PMC7801270__F1 Melatonin signaling pathway in the occurrence and development of OA NFAT5 IL18 NAMPT SIRT1 PMC8082653__F4 N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies P2RX6 SIAH1 FBXO45 SMAD2 EIF3A EZH2 NKAP YTHDF1 DROSHA NKX3-1 DGCR8 PHLPP2 ALKBH5 YTHDF2 METTL14 METTL3 SOX4 LHPP PMC4880841__F1 Summary of NDR/LATS kinase signalling functioning downstream of Ste20-like kinases and upstream of the Hippo effectors YAP/TAZ LATS1 AAK1 LATS2 PMC8082653__F3 N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies YTHDF2 BMF METTL3 IGF2BP2 TRAF2 SEC62 PMC7955048__F5 Direct catalytic asymmetric synthesis of Alpha-chiral bicyclo[1.1.1]pentanes PC SHE PMC4933865__F6 Multiple modes of action of Mg2+ in attenuating Pi-induced VC in HAVSMC CASR TRPM7 SMAD1 MGP RUNX2 CTNNB1 PMC12037972__F1 Overview of serine-glycine-one-carbon (SGOC) metabolic pathway PHGDH PSAT1 PSPH PMC11456611__F7 Colorectal cancer: therapeutic targeting of oncogenic signaling cascades TSC2 TSC1 PTEN CCND1 PMC5354739__F1 Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma ABCC10 ABCC1 DHFR ABCC3 GGH TYMS SLC19A1 ABCG2 HEL-S-70p ABCC2 FPGS ABCB1 PMC2688935__F3 Networks used to generate simulated data EGF BAD SOS1 GAR1 NRG3 SHC2 AREG MTOR MYC NRG4 ARAF HRAS CRK PLCG1 CBLC PRKCA GRB2 PMC7926039__F2 Fibroblasts involved in the EPAC pathway and connection with fibrosis SMAD2 SMAD4 RHO PMC10603966__F5 Schematic view showing melatonin-mediated actions in stroke STAT3 SIRT3 NLRP3 KEAP1 TLR4 TRAF2 SIRT1 MPO PMC8561765__F7 Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells KEAP1 MAF PMC11456611__F2 The diverse signaling cascades implicated in colorectal carcinogenesis BAD ERBB4 SMAD2 APC FASN SMAD4 MTOR MYC IGF2 TGFBR1 CTNNB1 TGFBR2 LATS1 LATS2 SUFU AXIN1 CASP3 ERBB2 ATM SMO MDM2 GRB2 FADD PMC3466514__F1 S6K1 in ER-positive breast cancer EGF TGFA TSC1 EGFR ERBB2 PTEN IGF1R IRS1 PMC1667087__F9 F igure 9.— SPEN NEDD4 EGFR PMC6891198__F7 ALK and RET inhibitors promote HLA class I antigen presentation and unmask new antigens within the tumor immunopeptidome STAT1 ALK RET PMC4002321__F2 PI3K/Akt pathway involved in tumorigenesis BAD PTEN CCND1 EIF4E PMC10818876__F2 Signaling pathways triggered by traditional medicine-derived SCFAs STAT3 GSDMD NLRP3 AHR HIF1A MTOR MYD88 PMC6696851__F8 Schematic diagram depicting possible mechanisms involved in the anti-fibrotic effect of melatonin and PAA TGFBI SMAD2 LRP5 WNT1 LRP6 CTNNB1 PMC4592520__F1 MicroRNAs in placental health and disease DGCR8 AGO2 DROSHA PMC3048826__F9 Hsp72 is an important intracellular protein to inhibition of HMGB1 release and proinflammatory function in macrophages () HMGB1 IL16 PMC5352135__F8 miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis DVL1 BAX CCNE1 GC CDK2 CTNNB1 PMC2842492__F2 Transcripts regulating the mammalian cell cycle are up-regulated in the proliferative-phase endometrial epithelium CDC2 ATR CDC20 PCNA APC SMAD4 MYT1 ORC3 SKP2 ORC2 CDK6 CDK2 ATM MDM2 CDK4 PMC6429142__F8 Tangeretin-induced apoptotic pathway in BFTC-905 bladder cancer cells BAX BAD BCL2 PMC4300205__F1 Human Cerberus Prevents Nodal-Receptor Binding, Inhibits Nodal Signaling, and Suppresses Nodal-Mediated Phenotypes SMAD2 NODAL PMC6026692__F2 Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation HMGB1 TLR4 MFN2 TLR9 VCAM1 IL1B PMC3048826__F8 Hsp72 regulates oxidative stress-induced HMGB1 cytoplasmic translocation and release HDAC1 LAMP2 HMGB1 PMC4786758__F3 Position of miRNA targeted genes (red box) in endometrial carcinogenesis pathway (KEGG) PIK3CA BAD SOS1 EGFR APC AKT3 GSK3B ERBB2 HEL-S-28 PTEN KRAS AXIN2 PMC9699401__F11 Ginsenoside Rh2 Induces HeLa Apoptosis through Upregulating Endoplasmic Reticulum Stress-Related and Downstream Apoptotic Gene Expression DDIT3 ATF4 BBC3 PMC3481527__F3 CB1 cannabinoid receptor signalling and regulation of neural stem/progenitor cell proliferation RAP1GAP STAT3 GSK3B SRC PAX6 PMC4452102__F1 TLRs in human gastrointestinal pathology: health condition and inflammation IFNG IRF3 PMC5069789__F2 Epigenetic mechanisms mediate DEP effects on asthma pathogenesis TSLP TGFA EGFR IL18 AHR HIF1A IL6 CYP1A1 CCL20 NOTCH1 PMC2974067__F1 Signaling pathways that regulate longevity in C SGK1 KRI1 PMC7400296__F1 Fibrosis regulation by RBM7 via NEAT1 ncRNA decay in the lung CXCL12 RBM7 PMC7016888__F4 Cell signaling determination of artery, vein and lymph identity EPHB4 PROX1 HEY2 FOXC1 SOX18 PMC4873349__F2 IPA canonical pathway Cell Cycle: G1/S Checkpoint Regulation with up-regulated genes in the IR-induced common translatome highlighted in pink MAX BMI1 NRG1 ATR SIN3A PAK1IP1 SMAD4 CDK2 ATM MDM2 SUV39H1 PMC10299070__F3 Core pathways involved in development of Peyronie’s disease and their interrelationships IGF1 DKK1 SMAD2 PTCH1 SMAD4 SHH SMO ARHA SFRP1 PMC7583981__F1 Pyroptosis canonical pathway and non-canonical pathway NLRC4 GSDMD NLRP3 AIM2 PMC7583981__F2 Oxidative stress and ER stress in inflammation in DKD NLRP3 TXNIP NOX4 IL1B PMC12249569__F1 Mechanistic model linking gut dysbiosis, insulin resistance, and autism spectrum disorder TLR1 TRAF6 TNF IRS1 MYD88 PMC7859757__F4 ER stress can be triggered by alcohol, bile acids, pancreatic toxins, and increased protein synthesis ATF4 EIF2A XBP1 PMC7551201__F2 RAGE signaling pathway CDC42 EGF RECK SMAD2 SMAD4 MTOR CTNNB1 MYD88 SOX9 TLR4 CCL7 MMP2 MDM2 SLC39A10 S100A4 SP1 ARG1 MMP9 IL1A IL6 RAC1 ZC3H12A BCL2 KLF5 ENPP2 LCN2 SIRT1 PMC12040832__F1 Underlying protective mechanism of EOs against oxidative damage induced by chemical overexposure BAX CYP2E1 KEAP1 SMAD2 PC BCL2 MTOR MPO PMC5766484__F4 Expression of key biological pathways involved in M HEL-S-99n LPO MRO HEL-S-11 TEF PMC2666018__F12 Differential Requirement for MEK/ERK and SMAD Signaling in PAI-1 and CTGF Expression in Response to Microtubule Disruption EGFR ARHA SRC PMC7115204__F2 Signaling pathway of G-CSF in breast cancer HRAS TGFA MSI1 BMP4 MMP2 MTOR GPR49 RAC1 PMC5570234__F2 MinePath viewer for BM20 region normal versus high Alzheimer's disease based on the CERAD classification CDC42 TF RAF1 PIK3R5 SOS1 PXN AKT3 PRKCZ SHC2 NCF1 PRKCB STAT1 ROCK1 WAS CHUK ITK GNAI1 VAV3 GNB5 PTK2B ARHA RAC1 SET HRAS CRK PREX1 GSK3A PARD3 c-fgr ELMO1 PAK1 FOXO3A NFKB1 RAP1A PLCB1 NFKBIA ADCY1 MAP2K1 GRB2 PMC6468358__F1 ADRB2 signaling in prostate cancer BAD VASP MCL1 ADRB2 PMC11941040__F3 Acute inflammation and molecular pathways induced by red complex bacteria and Fusobacterium nucleatum in endothelial cells TLR1 OMP TLR4 CD14 VCAM1 ABCA1 MYD88 PMC9406806__F8 Nano Modification of Antrodia Cinnamomea Exhibits Anti-Inflammatory Action and Improves the Migratory Potential of Myogenic Progenitors CDH2 TH DDX5 FZD4 TCF4 CTNNB1 PMC7214760__F1 Biosynthetic pathway of aromatic amino acids GALP MTR PMC8436866__F2 Research Progress on Mechanism of Neuroprotective Roles of Apelin-13 in Prevention and Treatment of Alzheimer’s Disease BAX NLRP3 TXNIP GSK3B ELF2 DKFZp666G145 ATF4 MTOR ABCA1 XBP1 PMC7583981__F5 Pyroptosis contributes to interstitial fibrosis NLRP3 SMAD2 IL18 SMAD4 PMC5206730__F6 Effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial CDC42 EGF NGF HGF RAB34 PAK1 ARF6 CD14 SRC RAC1 PMC7551201__F5 S100A8/A9 provides a premetastatic environment SLC39A10 IL10 SMAD2 CXCL1 S100A8 SMAD4 ARG1 ZC3H12A TLR4 CCL7 LCN2 ENPP2 S100A9 PMC7414267__F2 Pro-viral and antiviral roles of TRIM6 TBK1 MAVS TRIM25 STAT2 IFNAR2 IFNAR1 TRIM6 IRF3 JAK1 VAMP8 TYK2 PMC7551201__F6 S100A4 increased motility of tumor cells S100A4 TLR4 CCND1 CTNNB1 PMC5206730__F7 Effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial HEL114 CRK CRKL SHE PMC7816137__F3 Met1-linked ubiquitin machinery in inflammation and infection SHARPIN TBK1 OTULIN CYLD PMC7816137__F4 Met1-linked ubiquitin machinery in inflammation and infection SHARPIN MAVS OTULIN IRF3 CYLD UBE2L3 PMC3231924__F1 Simplified scheme for TLR signaling in enterocytes CSA2 TIRAP TLR9 TLR5 IRF3 TRAF3 TRAF6 MYD88 TLR1 TLR3 TLR4 NOD2 NOD1 PMC5197954__F1 Intronic microRNAs (miRNAs) and the miRNA-488/ZIP8/MTF1 pathway are critically involved in the pathogenesis of osteoarthritis (OA) MTF1 SMAD2 PMC8827164__F5 Transcriptional landscape of circulating platelets from patients with COVID-19 reveals key subnetworks and regulators underlying SARS-CoV-2 infection: implications for immunothrombosis RPL8 VWF RPS6 RPS2 RPS14 PIK3CD F13A1 ITGB3 ITGA2B FOS PRKCB RPS29 PLCG2 RPL10A LYN RPL7 PMC10480466__F7 Lenvatinib inhibition of EMT in ICC cells CDH2 PMC5724804__F5 SIRT6 histone deacetylase functions as a potential oncogene in human melanoma ATG10 BCL2L1 ATG3 NPC1 ATG12 SQSTM1 CTSS CLN3 BAK1 TNF PMC8960222__F2 Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells TFAM TOX MYC NRF1 PMC6374178__F4 Possible neurochemical/molecular pathways for stress-induced synaptic remodeling in medial prefrontal cortex GC MTOR BDNF PMC11887407__F4 Oncogenic GNAS activation and downstream signal transduction STAT3 SIK1 APC SIK3 BNIP3L MYC YAP1 CTNNB1 LATS1 BIRC5 SIK2 SHH SMO SRC CCND1 PMC10526836__F1 Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential STAT3 MAK JAK3 IL21R GRB2 JAK1 PMC11587777__F1 Immunopathological interactions in tuberculosis-associated hemophagocytic lymphohistiocytosis (TB-HLH) CXCL9 APC PMC5345529__F1 Interaction of VHL protein with HIF and other proteins including elongin B, elongin C and CUL2 TGFA VHL PMC3490581__F4 Illustration of fluxes in central carbon metabolism for metabolic phases II and III along the protein/ tradeoff MAL CPM CP PMC5344275__F4 Biological responses leading to angiogenesis driven by the HGF–Met pathway STAT3 HGF PMC4590678__F1 Genes involved in Parkinson disease and in the autophagy-lysosome pathway SCARB2 PINK1 SYNJ1 LRRK2 HEL-S-67p RAB7L1 SNCA TMEM175 SMPD1 VCP ATP6AP2 HEL-117 MEF2D LAMP3 VPS35 HEL-S-130P TFEB GPNMB FBXO7 PMC7465660__F5 Relationship between EBV proteins, hTERT, and NOTCH signaling pathway and the modes of action of compounds with lytic induction potentials BATF MSH2 EZH2 ZEB2 PMC5344275__F2 Signaling mechanisms responsible for promotion of cell survival mediated by HGF–Met pathway BAX BAD FAS HGF PMC5344275__F1 Schematic structures of HGF (A) and Met (B) STAT3 GRB2 PMC8298384__F9 Anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice FOXO1 GSK3B PTPN1 IRS1 PMC7933474__F1 Schematic diagram depicting a proposal model of the complex relationship between autophagy and exosomes in the context of pancreas ductal adenocarcinoma (PDAC) and its environment TP53INP1 ADAM9 MMP9 IF2G PMC3491835__F7 5-HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia RHEB TSC2 TSC1 MTOR PMC5476461__F4 Regulation of antioxidant production by HIF-1 MTHFD2 PHGDH GCLM MTHFD1L PSAT1 SLC7A11 HEL-S-51e PSPH PMC6406290__F6 Network analysis of differentially expressed genes RAPGEF2 TSPYL2 PMC12065456__F3 Communication between cancer-associated fibroblasts and specific tumor cells via integrins CDH2 CD36 SMAD2 THBS2 GC ARHA CXCR4 PMC8753223__F7 Inducible Sbds deletion impairs bone marrow niche capacity to engraft donor bone marrow after transplantation CXCL12 SBDS IGF1 MSC MX1 PMC12065456__F4 Summary diagram of the interplay between integrins and cancer stem cells in specific tumor types KLF4 STAT3 CD9 TET3 ERBB2 GSC CTNNB1 PMC8777512__F1 O-GlcNAcylation links oncogenic signals and cancer epigenetics OGA OGT GNPNAT1 PGM3 GFPT1 PMC5515442__F8 Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells RPE TSC2 SMAD2 MTOR PMC12235270__F2 Unraveling the Hippo pathway: YAP/TAZ as central players in cancer metastasis and drug resistance LATS1 LATS2 YAP1 PMC12065456__F2 Pro- and anti-tumorigenic effects of integrins on interaction between endothelial cells and particular tumor cells CDC42 EGF CD36 HEL-S-28 MTOR RHO RAC1 PIGF COX2 CD93 MMRN2 VCAM1 SRC TRAF2 NCL PMC7226356__F1 Perforin-granzyme, intrinsic (mitochondrial) and extrinsic apoptotic pathway BAX TNF PMC11750448__F4 Network view depicting hub metabolites, their associated miRNAs, and the target genes within the corresponding metabolic pathway CYP2E1 BAAT GAD1 GADL1 CYP2C8 GGT7 PMC11960544__F3 Exploration of the signaling pathway of extracellular matrix (ECM)-receptor interaction in stem cells from human exfoliated deciduous teeth-conditioned medium (SHED-CM) CD44 VWF CD36 DMP1 NPNT CHAD CD47 PMC8547806__F2 Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGFB/Wnt/Beta-Catenin Pathways and PPARG EGF APC MB CTNNB1 PMC8547806__F3 Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGFB/Wnt/Beta-Catenin Pathways and PPARG TLR4 APC CTNNB1 TGFBR1 PMC7728579__F2 Transsulfuration and H2S oxidation pathways C2 ETHE1 SUOX PMC8539471__F3 Controversial Role of Adiponectin in Appetite Regulation of Animals ADIPOR1 POMC NPY ARC PMC5578419__F2 Experimental models of hepatitis B and C — new insights and progress CD81 NPC1L1 CLDN1 PMC3163776__F3 IRE1Alpha-XBP1 pathway in glucose homeostasis HEL-S-99n DNAJB9 TRAF2 UNK PMC3163776__F2 IRE1Alpha-XBP1 pathway in inflammation BAX PAIP1 TLR4 IL6 TRAF6 TNF TRAF2 PMC4273448__F7 The structure-function relationships of IRAK-M based on this study TRAF6 MYD88 PMC4817806__F8 Proposed mechanism by which DZNep epigenetically reactivates Wnt/Beta-catenin signaling to promote osteogenic differentiation of osteoporosis BMSCs WNT1 EZH2 WNT10A PMC5423221__F5 Metastatic niches in the bone marrow CDH2 CXCL12 MTOR SRC CXCR4 PMC4620719__F2 Cross-regulation of intracellular membrane-associated proteins and microRNAs in B cell differentiation ATG16L1 ATG12 ATG5 PMC9687179__F1 Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription GIT2 FBP1 ATF1 PMC6651255__F2 STNM01 blocks the glycosaminoglycan synthesis pathway through RNA-induced silencing complex (RISC) activation GAL CS PMC4364402__F2 Models of peripheral and spinal itch circuitry GRPR ITCH PMC6059739__F3 Regulation of the Wnt pathway via YAP/TAZ DVL2 TCF4 CTNNB1 PMC4445092__F2 Schematic presentation of testosterone-activated extra-nuclear signaling pathways SHBG EGFR SRC PMC6451008__F1 PTEN S-nitrosylation by NOS1 inhibits autophagy in NPC cells PTEN MTOR PMC7967197__F1 CyclinD/CDK4/6 involvement in overpassing resistance to aromatase inhibitors EGFR MTOR CDK4 PMC9021737__F5 De Novo Assembly of 20 Chicken Genomes Reveals the Undetectable Phenomenon for Thousands of Core Genes on Microchromosomes and Subtelomeric Regions SYK AXL TXNIP RELB KHSRP PPP2R1A TRAF3 FLNA HUWE1 CACTIN BTK CLU IL36RN TRAF2 SND1 PMC4658488__F1 Cholesterol biosynthetic pathway and cholesterol synthesis inhibitors used in the current study IDI2 IPP SOST HMGCR SC5D PMVK DHCR24 DHCR7 IDI1 MVK PMC5859872__F2 Cooperative interactions between the tumour and surrounding cells in tumorigenesis EGFR MMP2 SCRIB FOS PMC5859872__F3 Non-cell-autonomous overgrowth VPS25 TSG101 SCRIB PMC3124126__F1 Molecular signaling cascades which normally control mTORC1 activity and may become dysregulated in B-cell lymphomas leading to aberrant mTORC1 signaling activation RHEB TSC2 TSC1 PTEN PMC5859872__F1 Cell competition mechanisms ROBO2 SCRIB PMC6421314__F1 Relationship between Fe deficiency responses in dicots and responses to pathogens (necrotrophs or biotrophs that elicit SAR) or to beneficial microbes that elicit ISR COMP PMC4313785__F1 Figitumumab (CP) is a biased agonist of the IGF1R that selectively promotes Beta-arrestin1 (Beta-arr1) signaling in cancer cells IGF1 IRS1 CP PMC3928074__F1 Phase II Trials of Single Agent Anti-VEGF Therapy for Patients with Chronic Lymphocytic Leukemia (CLL) STAT3 PMC3307977__F6 Schematic diagram of the FGF2-STAT3-PAX3 signaling pathway PAX3 STAT3 FGF2 PMC5430039__F4 Host miRNAs that favor viral replication via the inhibition of the Jak/STAT signaling pathway IRF9 JAK1 PMC11889548__F5 Abnormal Hedgehog (Hh) signal transduction caused by EFCAB7 mutation EVC2 EVC MYH6 SUFU GIP SMO EFCAB7 NKX2-5 PMC7865717__F3 RSV could prevent oxidative stress involved in the development and progression of ocular diseases such as age-related macular degeneration (AMD) RPE FRK VEGFA PMC7865717__F4 Proposed model of resveratrol action during oxidative stress in glaucoma TFAM RPE SIRT1 PMC8040975__F3 TSP1 and ligands in glucose metabolism and diabetes mellitus UCP2 TGFB1 CD36 SIRPA CD47 PMC8040975__F4 TSP1 in adipose metabolism and obesity STAT3 TGFB1 CD36 CD47 PMC5843355__F1 Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery APRT GMPR ADSL GDA PMC8804234__F3 Molecular Mechanisms of Clonorchis sinensis-Host Interactions and Implications for Vaccine Development BAMBI TLR4 IL33 MYD88 PMC4190578__F5 Metabolic pathways for carbohydrates, fatty acids and phenylalanine CAD UGDH FRK PMC3154472__F1 Identification and Phylogenetic Analysis of Heme Synthesis Genes in Trypanosomatids and Their Bacterial Endosymbionts CPOX FECH UROD UROS PMC6477175__F1 Distribution of target proteins of baicalin in the “Alzheimer’s disease pathway” LPL IDE BAD HEL-S-62p APOE CASP3 FES SNCA APP HEL-S-11 LBP FADD PMC7370155__F1 HMGB1 mediated neuroinflammatory response in TBI BAX HMGB1 TIRAP TLR4 TRAF6 IL1B MYD88 PMC3076058__F2 Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction CDC42 SMURF1 CCM1 ARHA PMC6477175__F2 Distribution of target proteins of icariin within the “Alzheimer’s disease pathway” LPL IDE BAD HEL-S-62p APOE CASP3 FES SNCA APP HEL-S-11 LBP FADD PMC7370155__F2 HMGB1-mediated EBI post-SAH STAT3 HMGB1 TIRAP TLR4 TRAF6 MYD88 PMC9605147__F1 Let-7 microRNAs Are Possibly Associated with Perineural Invasion in Colorectal Cancer by Targeting IGF Axis IGF2R INSR IRS1 PMC6395431__F1 Biochemical pathway ASL ALDH18A1 OTC ARG1 ORC1L PMC4693271__F1 Toll-like receptors (TLR) 4-mediated signaling of innate immune responses TLR4 TAB3 MAL RELB IRF3 TRAF3 TRAF6 MYD88 PMC6126897__F2 Functions of iTreg in the TME PTEN FOXP3 MTOR PMC4693271__F4 Ubiquitination-mediated signaling cascades in canonical and non-canonical NFKB pathways CD40 SHARPIN TRADD TAB3 RELB TRAF3 TRAF2 PMC4989114__F1 Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate RDH10 HEL-S-4 ALDH8A1 BCO1 PMC6477175__F3 Distribution of target proteins of dihydromyricetin within the “Alzheimer’s disease pathway” LPL IDE BAD HEL-S-62p APOE CASP3 FES SNCA APP HEL-S-11 LBP FADD PMC6477175__F4 Distribution of target proteins of hesperidin in the “Alzheimer’s disease pathway” LPL IDE BAD HEL-S-62p APOE CASP3 FES SNCA APP HEL-S-11 LBP FADD PMC11842335__F3 Activating the Nrf2/KEAP1 signaling pathway to counteract oxidative stress and subsequent inflammatory reactions, including mastitis, induced by LPS through the administration of bioactive compounds from an external source KEAP1 TNF PMC11842335__F2 Underlined molecular mechanism during mastitis development KEAP1 TNF PMC7887651__F4 Immunometabolic interplay in obesity STAT3 IRF3 IRS1 PMC6909602__F6 Schematic of the mechanism by which Alpha-synuclein induces the accumulation of microglia through CXCL12/CXCR4 CXCL12 TLR4 NFKB1 SRC CXCR4 PMC3449280__F1 An engineered eukaryotic protein glycosylation pathway in Escherichia coli AIG1 ALG13 ALG1 PMC10825793__F3 EBV-miRNAs modulating inflammatory signaling pathways JUN FYN MAVS TRADD VAV2 JAK3 CHUK IRF7 TNF FOS PMC8435254__F2 Serum L‐arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case‐control study VIP DHH PMC4957398__F2 Signaling of pexophagy by ROS, hypoxia and inhibition of PEX5 export from peroxisomes NBR1 UBC ULK1 PEX5 ATM PMC3228119__F1 PI3K/AKT/mTOR signaling network regulates cell survival, proliferation, migration, metabolism, and apoptosis, integrating the growth factor signaling pathway, nutrient status, and other oncogenic pathways RHEB EEF2K TSC2 BAD RICTOR TSC1 PTEN MTOR IRS1 EIF4E PMC8874739__F6 PACAP-38 Induces Transcriptomic Changes in Rat Trigeminal Ganglion Cells Related to Neuroinflammation and Altered Mitochondrial Function Presumably via PAC1/VPAC2 Receptor-Independent Mechanism MYLK2 SPEN PLOD1 TNNC1 STIM2 SPHK1 PPP3CA TRDN ADCY8 PLCE1 PLCG1 HRC F2R BCR CASQ2 PDE1B PI3 FGFR1 ADRB2 ASPH CALM1 RYR1 GRIN1 CAMK2G PMC4677817__F2 Contribution of Metabolic Reprogramming to Macrophage Plasticity and Function TRO ASL ARG1 PMC4383156__F5 The major pathways involved in the molecular mechanisms of cancer CDC42 CRK HEL-S-11 GRB2 FADD PMC1905066__F5 CRP and mannan-binding lectin (MBL) on complement activation CRP HEL-S-62p ME2 C2 C1S C1R C9 PMC6117622__F4 MAPK signaling pathway MAX EGF MAFK JUN FAS EGFR BAP1 CD14 TRAF6 DAO FLNA NLK GCK GRB2 BDNF TRAF2 PMC11373554__F7 MetaCore enrichment pathway analysis of genes coexpressed with KDM5B in pancreatic cancer BARX2 CARF FOXK1 EGFR TERT TCF4 ARHA CTNNB1 FOXM1 GRIP1 SHH APP HDAC2 TDG PMC11373554__F5 MetaCore pathway analysis of the coexpression gene network involving KDM1A in pancreatic cancer CDC42 ATR RAP1A APC ATM RHO RAC1 CTNNB1 PMC5957297__F3 MAPK pathway in BRAF-mutant melanoma HGF EGFR BRAF NRAS PMC11373554__F6 Expression of the KDM5A signaling pathway in pancreatic cancer (MetaCore) TH ATR HGF GDNF SPO11 BRCA1 RYBP ATM RET CDK4 PMC5957297__F4 MAPK pathway bypass in melanoma BRAF PMC5957297__F5 MAPK pathway indifference in melanoma BRAF PMC9705963__F1 Ferroptosis in osteosarcoma: A promising future KDM4A TF POR STAT3 SLC3A2 LOX STEAP3 GPX4 LPCAT3 SLC7A11 HEL-75 PMC6527835__F1 Schematic illustration of the mammalian ganglioside synthesis pathway UGCG GM2A HEXB HEXA B4GALNT1 ST3GAL5 B4GALT5 B3GALT1 PMC4118962__F1 Interleukin-1/Toll-Like Receptor-Induced Nuclear Factor Kappa B Signaling Participates in Intima Hyperplasia after Carotid Artery Balloon Injury in Goto-Kakizaki Rats: A Potential Target Therapy Pathway IRAK2 TRAF6 IRAK4 MYD88 PMC3439646__F1 Complement and dysbiosis in periodontal disease IFNG TLR1 TLR4 GSK3B CD14 IRF1 CXCR4 RAC1 PMC7213603__F4 Schematic representation for a proposed pathway showing upstream regulation of EZH2 in SLE CD4+ T cells MLST8 EZH2 MTOR DEPTOR PMC11986939__F3 PPI network vs RAF1 INSR EGFR KIT IL2 NR1C2 UMPS SRC PMC4154952__F5 Mechanical offloading of incisional wounds is associated with transcriptional downregulation of inflammatory pathways in a large animal model TP73 MRPL11 LR8 FRK DUSP11 PECAM1 CLEC4C EGLN1 CLEC4A ARPP-21 EEF1A1 PPAN ZNF76 PMC9463134__F1 InterferonG receptor pathway: a new way to regulate CAR T cell-solid tumor cell adhesion IFNG JAK1 PMC4530463__F1 Basic biology and role of interleukin-17 in immunity and inflammation IL17RC EBP TAB3 TRAF5 TRAF6 TNF TRAF2 PMC8579641__F1 Regulatory mechanism of neutrophil extracellular traps in cancer biological behavior SYK HMGB1 TLR4 RIPK1 IL8RB SRC TNF CTSC PMC8579641__F2 Regulatory mechanism of neutrophil extracellular traps in cancer biological behavior STAT3 HEL-S-76p HMGB1 TLR4 TLR9 MMP9 PMC9204485__F1 Love-Hate Relationship Between TGFB Signaling and the Immune System During Development and Tumorigenesis TF SMAD2 SMAD4 RHO GRB2 MTOR TRAF6 FURIN PMC6362006__F7 Schematic depicting ghrelin’s proposed effect on contact dermatitis and psoriasis TRADD TRAF2 IL1B FADD PMC9371342__F1 Summary of the major components of the extrinsic and intrinsic pathways of apoptosis induction following viral infection BAX CGAS TLR3 IRF3 ATF4 TNF PMC4370699__F5 Activation of CNTF/CNTFRA Signaling Pathway by hRheb(S16H) Transduction of Dopaminergic Neurons In Vivo CNTF TSC2 TSC1 PMC5241776__F2 Molecular Characterization of Pediatric Restrictive Cardiomyopathy from Integrative Genomics JUND PXN HIF1A MYC FBXO32 ARR3 INHBA MOG LEFTY2 UCN WNT4 CRHBP PLEKHF2 TINF2 TUBA3E RPSA HAPLN1 DVL2 UBL4A TNF FOS HRAS ENG SFRP4 RICTOR PRKAB2 THBS4 GRB2 TES VDAC3 MYH6 PRKAG2 MTOR PRKCH SUMO1 HEL-S-182mP ARHGEF2 GGA1 CCND1 DBF4 CCND3 SMOC2 ARHA KRAS BANF1 CD47 NR3C1 ELAVL1 RELA CRHR2 LEF1 PMC5086619__F1 Mammalian target of rapamycin complex 1 (mTORC1) pathway and translation initiation EIF4B MTOR DEPTOR EIF4E PMC2424294__F2 Induction and lifetimes of signal transduction proteins (and their mRNAs) at various positions in signal transduction networks TSC2 CRAT TGFA EPOR CYC1 PTEN PMC11240421__F13 CK1A interplay in the NFKB pathway TRADD OTULIN TAB3 IRAK1 YBX1 TRAF6 IRAK4 MYD88 BCL10 RELA TRAF5 RIPK1 TRAF2 CYLD PMC10755915__F6 Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism KLF4 PPARG CD36 MSR1 ORM1 MT1G CD163 CYP27A1 ABCA1 PMC4584235__F6 MiR-146 a/b effect on induction of endotoxin tolerance STAT3 TLR4 TRAF6 TNF RUNX3 MYD88 PMC6614380__F1 Pathways to B cell memory CD40 ICOS BCR ELL TLR7 PMC9315518__F8 Identification and Functional Analysis of Individual-Specific Subpathways in Lung Adenocarcinoma NID1 ID2 AFP AMOT SMAD2 APC SOX2 PMC5869528__F10 Cytokine-cytokine receptor interaction signaling pathway FLT3 IL19 EGF LTA FAS LEP LTBR OSM CCL3 CCR2 EPO CCR3 CSF3R IFNK INHBB CDA FLT4 CCL21 IF2D TPO XCL2 KDR AMH IF2B1 CSF2 LIF BMP7 IL4 KIT IL6 TNF IF2G LTB ACTR2 TSLP CCL19 IL23R EDAR TNLG7C IL23A PMC8467693__F1 Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models WNT3A DKK1 MYC CCND1 CTNNB1 PMC5869528__F11 Jak-STAT signaling pathway PIM1 EPO PMC9171628__F2 Rational Use of Complement Inhibitors in Kidney Diseases MASP2 HEL-S-62p C4B_2 PMC12146007__F15 Bioactive components-modified smart implants for vascularization and osteogenesis MAGT1 COL4A2 HDAC7 RUNX2 PMC5869528__F12 NOD-like receptor signaling pathway INA NOD2 CCL2 TRIP6 PMC12179907__F2 Epigenetic modification mechanisms in congenital scoliosis MYST4 APC ROR2 GSK3B PTEN ARHA SORCS2 RUNX2 RAC1 RNF213 CTNNB1 ROBO2 RHEB TSC2 TSC1 COL1A1 TNS3 GSE1 SRC FGF23 PMC6548783__F3 IL-6 production by blood leukocytes is altered in the RA-like PsoA patient in response to immune activators TRAF3IP2 NLRP3 TLR4 TRAF5 NOD2 AIM2 TRAF6 TNF TRAF2 IL1B PMC7016982__F1 Regulation of YAP at the level of the extracellular matrix involves various proteins involved in stabilizing and activating YAP PDLIM7 SRC PMC7016982__F2 Pathways and interplay with regulate mechanotransduction in the context of chronic disease and polarity PIEZO1 UCP1 RHO IRS1 PMC6936658__F5 Significantly down regulated genes (from the current study; PLIN1, SORBS1, FABP4, etc) involved in the PPAR signaling pathway is highlighted in red color LPL HEL-S-28 PLTP PMC7758401__F1 Establishment, maintenance and erasing of 5mC in plants TES AGO4 AGO2 PMC7912637__F6 Mechanistic diagram for microglial IRF5/4 activation TLR4 IL4 ARG1 IRF4 TRAF6 IRAK4 MYD88 PMC11557232__F6 Model for the functions and acquisition pathways of acetyl-CoA in multiple organelles of Toxoplasma APC MAL CIT PMC8237569__F3 Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F420H2-dependent reduction FGD1 DHFR DDN PMC5226065__F4 Mechanisms underlying SQ induced self-renewal HEL-S-28 RHO MTOR CCND1 PMC206993__F9 SPARC-mediated regulation of and coupling to the TGFB signaling system SMAD2 SPARC CDK2 PMC9358627__F4 Association of ABCC2 haplotypes to Mycophenolic Acid Pharmacokinetics in Stable Kidney Transplant Recipients UGT1A7 UGT1A9 CES2 UGT1A10 IMPDH1 CYP2C8 IMPDH2 UGT1A8 CYP3A4 UGT2B7 ABCC2 ABCB1 PMC6528834__F10 DUAL INHIBITION OF ERK1/2 AND AKT PATHWAYS IS REQUIRED TO SUPPRESS THE GROWTH AND SURVIVAL OF ENDOMETRIOTIC CELLS AND LESIONS BAD GSK3B CASP3 BCL2 PMC8623546__F5 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease RHEB TSC2 TSC1 MTOR PMC8326529__F9 Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis RHEB MYB TSC2 BCR CD37 RBL2 CD19 PTEN PMC3035969__F5 Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression MAX ECSIT JUN FAS RELB GNG12 MYC RAC3 TGFBR1 NTF3 MOS NF1 UNG NLK GRB2 TRAF2 PMC8623546__F6 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease STAT3 STAT1 PMC8623546__F7 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease APC GSK3B BBS4 BBS1 NPHP3 PMC4666325__F2 BCR signaling and downstream pathways SYK BTK BCL10 BCR CARD11 LYN MTOR PMC11743450__F3 Deregulated cell signaling pathways targeted by Bergenin STAT3 TLR4 HIF1A MDM2 MTOR PMC8623546__F9 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease SUFU PTCH1 SMO PMC8326529__F1 Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis JUN IL1B PMC6180204__F1 Negative effects of resveratrol on NFKB via several pathways in SCI CSA2 TRADD TIRAP TLR4 RIPK1 MYD88 PMC7793647__F2 Major signaling pathways of GILZ JUN FOXO3A GC CPO IL6 TNF IL1B PMC12108254__F2 Steps involved in irisin production and the molecular cascades underlying its biological functions MAPK1 STAT3 CASP9 TLR4 NTRK2 UCP1 SREBF2 MTOR BDNF MAPK3 PMC8321552__F2 Kyoto Encyclopedia of Genes and Genomes (KEGG) for the nucleotide excision repair pathway RFWD2 XPA FUS ATR PMS2 PCNA SMC3 SMAD4 PTEN MYT1 MTOR MYC CDK7 ATM MDM2 MSH6 CETN2 SIAH1 MSH2 MSH3 PERP SSB XPC MLH3 CASP3 CDK2 MCM2 PMC9033023__F1 HSP90 mediates IFNGamma-induced adaptive immune resistance in pancreatic cancer IFNG STAT1 IFNGR2 IFNGR1 TSPAN5 JAK1 PMC3616003__F10 MicroRNA-301a Mediated Regulation of Kv4.2 in Diabetes: Identification of Key Modulators KCND2 SIX1 IRX5 HEL-S-133P MYH6 KCNA4 KCNA5 SCN5A PITX2 MEF2C SCN1B MYH7 GATA6 GATA4 KCNJ2 PMC6540009__F6 Scheme of the effect of pioglitazone on CKD-mediated ER stress in CKD-MSCs OPA1 MFN1 MSC ATF4 EIF2A PMC2669301__F1 Tyrosine kinase network regulating mast cell activation SYK STAT1 BTK KIT VAV1 LYN GRB2 SRC LAT2 GAB2 PMC3092918__F1 Metabolic network used for metabolic flux analysis GLCE GAL MAL CIT PMC5884123__F8 Schematic diagram demonstrates the proliferation and apoptosis pathways including the upstream and downstream cascades activated by VEGFC in the GC-1 cells VEGFC EGR1 CCND1 FOS PMC514912__F7 Model showing the cooperation of the BLM and the FA pathways in the response to replication arrest induced by either DNA crosslinks or UVC and HU exposure FANCD2 MRE11A BLM PMC11053446__F10 KEGG pathway analysis for DE mRNAs in tracheal tissues from chickens infected with IBV DMV/1639 or IBV Mass41 CD40 CD80 TIRAP IRF9 CTSK TLR9 CD14 CPO IRF3 TRAF3 TRAF6 RAC1 MYD88 CTRL TLR3 PDC TYK2 LBP FADD PMC4453937__F5 Summary of SIRT1 regulating the apoptotic upstream pathways within a cardiomyocyte in exercise-trained SD rats BAD FAS IGF1 PMC8929692__F4 Major metabolic pathways upregulated in the cells utilizing 3-hydroxybenzoate, 4-hydroxybenzoate or hydroquinone as a sole carbon source CORT MGA tmp_locus_29 CPO SHE PMC10917925__F2 Pathways included in the model NRP1 PTEN HIF1A SRC HES1 CIT PMC11513379__F2 Nanomedicine in HNSCC therapy-a challenge to conventional therapy STAT3 EGF TGFA PCNA EGFR PTEN IGF1R MTOR MAP2K6 COX2 PAK1 GRB2 SRC RET PMC2864453__F1 Nuclear factorKB (NFKB) can be activated by a multitude of different stimuli, like TNFA, LPS and CD40L CD40 TLR4 RELB CD14 PMC7865812__F1 Contribution of transcription factors (TFs) to disease progression FOXA1 SOX2 EZH2 HIF1A MYC XBP1 RB1 SOX6 SOX9 ASCL1 SOX3 SOX7 TWIST1 SOX8 SOX4 SOX5 PMC7339106__F3 Tumor expressed CD200 inhibits the expansion of myeloid cells in TME CD200 PMC4170615__F6 Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma MAX CRK JUN FAS TNFSF6 HEL-S-11 PMC5472345__F1 The NAD+ salvage pathway and its control by the circadian clock STAT3 FOXO1 NAMPT NHLH2 SIRT1 PMC4761106__F2 Hereditary Melanoma: Update on Syndromes and Management - Emerging melanoma cancer complexes and genetic counseling TF BAP1 ACD TERT POT1 PMC10758965__F2 Regulatory mechanisms of one-carbon metabolism enzymes DHFR YBX1 TYMS HEL-S-51e MYC FOXM1 MTHFD1 PHGDH SHMT1 MTHFD1L MTHFD2L PSAT1 ATF4 MTR PSPH PMC3368374__F1 In young muscle, abundant serum IGF-I can stimulate protein synthesis by activating Akt/mTOR/p70S6K pathway RHEB TSC2 IGF1 SMAD2 GGH MTOR PMC6739326__F8 Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKA signaling pathway CAMKK2 FGF21 FGFR1 PMC8880314__SF1 Cannabidiol Downregulates Myocardial de Novo Ceramide Synthesis Pathway in a Rat Model of High-Fat Diet-Induced Obesity ASAH2 UGCG SPHK2 tmp_locus_29 SPHK1 HEL-S-5 SPTLC1 KDSR PMC5164846__F2 Fine-tuning vascular fate during endothelial-mesenchymal transition TGFBR2 FRS2 SMAD2 TGFBR1 PMC8697445__F1 Enhanced production of Gamma-amino acid 3-amino-4-hydroxybenzoic acid by recombinant Corynebacterium glutamicum under oxygen limitation MAL CIT PMC2292640__F1 SARS CORONAVIRUS AND INNATE IMMUNITY STAT1 RIGI MAVS TLR3 STAT2 IFNAR2 IRF9 IFNAR1 IRF3 TRAF3 ACE2 TYK2 PMC8406474__F2 NRF2 signalling pathway: New insights and progress in the field of wound healing RBX1 KEAP1 NQO1 MAF PMC8406474__F3 NRF2 signalling pathway: New insights and progress in the field of wound healing SIRT3 NLRP3 KEAP1 PGAM5 GCLC MTOR AIFM1 PMC6471541__F11 Proposed schematic depicting the signalling pathway via which TGFB1 promotes the osteogenesis and migration of osteoblasts MMP2 MMP9 RUNX2 PMC10758965__F3 Regulatory mechanisms of one-carbon metabolism enzymes ATF3 ATF4 MYC KDM4C PMC11018843__F4 Amyotrophic Lateral Sclerosis (ALS) and cytosolic DNA sensors PANX1 TBK1 BTK CGAS DDX41 IRF3 HEL-S-44 C9orf72 PMC10758965__F5 Regulatory mechanisms of one-carbon metabolism enzymes PAICS MTHFD1 PCNA DHFR MTHFD1L SHMT1 MTHFD2L TYMS HEL-S-70p MTHFS HEL-S-51e ADSL PMC11018843__F1 Main cytosolic DNA sensors and their downstream pathways TBK1 CGAS MLKL WIPI2 CCL26 AIM2 FADS2 IRF3 IFI16 MTOR CCL5 CXCL10 CCL2 SEC24C RIPK3 BTK ZBP1 DDX41 RIPK1 ATG5 CCL20 TRAF2 FADD PMC11018843__F2 Alzheimer’s disease (AD) and cytosolic DNA sensors TBK1 STAT1 CGAS STAT2 PQBP1 IFNAR1 AIM2 IRF3 IL6 CXCL10 PMC6070613__F8 Triptolide signaling pathway BAX FAS CDK2 PMC11018843__F3 Parkinson’s disease (PD) and cytosolic DNA sensors TBK1 CGAS PINK1 IFNAR1 AIM2 IFI16 IRF3 TOMM40 PMC6476043__F1 Proposed schematic representation of the immune response to MERS-CoV infection and how the invading virus is processed during an infection IL10 IL4 IRF3 IRF7 IL6 TRAF3 CXCL10 TRAF6 MYD88 IL-21 TLR3 TLR4 IL2 PMC8484489__F3 AP2/ERF, an important cold stress-related transcription factor family in plants: A review MYB ERF CBL ICE1 PMC4076637__F6 CDK4/6 is downstream of multiple pathways CDK6 ERBB2 CDK4 PMC5853807__F5 Proposed model of immunopathogenesis of Borreliella burgdorferi during early cutaneous infection CXCL9 IL10 KYNU KMO S100A8 IFIT3 IRF7 RSAD2 LILRB3 CXCL10 CXCL11 TLR1 IDO1 LILRB2 MX1 FOXP3 S100A9 CD68 PMC11770944__F3 Relationship between common targets of wogonoside and AS therapy and the top 15 enriched targets of the KEGG signaling pathway LTA LAT NR3A2 RELA ATM PDE4D PTGS2 TNF RAC1 PMC4836210__F4 Graphic representation of apoptosis signalling pathways BAX TRADD APAF1 FADD PMC5127718__F2 Endocytic Pathway in Microglia During Health, Aging and Alzheimer’s Disease RHEB TFEB OSTM1 M6PR PMC5513689__F1 Alcohol’s effects on the hypothalamic–pituitary–adrenal (HPA) axis and the stress response POMC IL18 TNF AVP PMC3712543__F4 Somatic variations in genes encoding proteins of the KEGG “Melanoma” signaling pathway POR ARAF HRAS EGF BAD EGFR PDGFA FGFR1 KRAS PMC10778204__F2 Representation of the important miRNAs that effectively regulate the Notch signaling pathway in glioblastoma UVRAG NOTCH2 DLL3 NOTCH1 PMC7415199__F2 Hypothetical diagram of the possible targets where melatonin may act against SARS-CoV-2 infection in the CNS TMPRSS2 STAT3 NLRP3 IL1B PMC2898418__F10 Schematic pathway of IL-8-mediated NAADP formation by CD38 in LAK cells TRPM2 GC PLCB2 LCK PMC4836210__F7 Graphic representation of apoptosis and viral replication BAD TRADD EIF2A HRK FADD PMC11011519__F2 NFKB and JAK/STAT Signaling Pathways as Crucial Regulators of Neuroinflammation and Astrocyte Modulation in Spinal Cord Injury STAT3 CLIC1 HEL-S-62p PMC8741374__F4 Huanglian Jiedu Decoction Exerts Antipyretic Effect by Inhibiting MAPK Signaling Pathway CRP IL15 BAX NOS2 EGF PTGER3 SELE EGFR CD40LG CXCL10 MYC CCL2 FOS MPO MAPK14 RB1 PLAT PON1 RELA PTGS1 MMP3 THBD BCL2 CYP3A4 PMC6563602__F1 Complement system as a biomarker of disease activity and response to treatment in multiple sclerosis C6 C7 HEL-S-62p C2 C1S C1R C9 C4A C4B_2 PMC5582909__F2 RAS pathway status in human DKD, based on urine concentration and enzymatic activity of RAS components CTSA CTSG ACE2 PMC6239977__F2 Calcium-calmodulin-calcineurn-NFaT-DYRK1A pathway to human beta cell proliferation CDC2 FOXM1 DYRK1A CDKN1C PMC2592633__F1 RNAi pathways in Drosophila AGO1 AGO2 DROSHA MAEL PMC10536099__F6 Interferon-λ Activates a Differential Response in Peripheral Neurons That Is Effective against Alpha Herpesvirus Infections STAT1 IFNLR1 IRF9 IFIT1 JAK1 OAS1 PMC3240659__F3 Repeated Small Perturbation Approach Reveals Transcriptomic Steady States ZFP36L2 UGCG ID2 SLC38A1 PTGS2 PMAIP1 EMP1 TGFBR2 MCM7 CDKN1A CNN3 CASP3 GADD45A SEMA3B PMC5897151__F3 Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson’s disease ALDH2 PINK1 HEL-S-53e LRRK2 HEL-S-162eP MAL TFEB PMC5482974__F3 Protein traffic steps mediated by PACS-1 and PACS-2 SYK ADAM17 ARF6 FURIN PACS1 PMC5482974__F4 PACS-2 Akt site and NLS together modulate membrane traffic, TRAIL-induced apoptosis, MAM integrity and the response to DNA damage BAX EGF ADAM17 ATM SIRT1 PMC7692234__F4 Hypothetical host-cell signaling pathways linking Cryptosporidium parvum infection and tumorigenesis APC IQGAP1 CTNNB1 PMC9099149__F1 Integrin Crosstalk and Its Effect on the Biological Functions of the Trabecular Meshwork/Schlemm’s Canal TRIO TIAM1 ARHA SRC RAC1 PMC8457726__F1 Environmental Exposure to Heavy Metals Contributes to Diseases Via Deregulated Wnt Signaling Pathways BCL9 ANGPTL4 SOST APC NOTUM CTNNB1 PMC8457726__F2 Environmental Exposure to Heavy Metals Contributes to Diseases Via Deregulated Wnt Signaling Pathways CDX2 SIAH2 RYK RHO CTNNB1 PMC4276949__F1 Hypothetical model of HGF/SF activation in cancer KLK4 KLK5 HGF HAL TMPRSS13 PMC9641817__F4 Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease IDO1 PDC PMC7312818__F3 Role of miRNAs in the host–pathogen interaction CFTR TRAF6 ACE2 MYD88 PMC11781169__F7 Proposed mechanism underlying TRIM32 in enhancing neuronal ferroptosis after SCI TRIM32 GPX4 ATM PMC11673384__F1 Driver mechanisms of ferroptosis POR STEAP3 LPCAT3 FACL4 PMC5494096__F4 Pipeline of cell cycle and MAPK signaling pathway DBF4 CDC20 PCNA CDC6 ORC6 SMAD2 SMC3 APC SMAD4 NODAL ORC1L MYT1 ARHA MYC ORC3 SKP2 ORC2 PITX2 BAMBI IFNG CDK7 CDC45 CDK2 MDM2 PMC4149353__F5 Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms VAMP2 ADAP2 PMC6747522__F2 Canonical and non-canonical signaling of FGF23 FGFR4 FGF23 FGFR2 PMC9221492__F1 Synthetic Vulnerabilities in the KRAS Pathway CDC42 TIAM1 RASSF1 ARF6 RHO GRB2 MTOR KRAS RALBP1 PMC7318172__F5 Graphic showing the signalling pathway by which SYT4 regulates melanogenesis via Ca2+ influx TRPM1 SYT4 DCT CAMK4 TYRP1 PMC11845729__F5 Expression pattern of differentially expressed genes involved in the Wnt signalling pathway, an ancient and evolutionarily conserved pathway regulates the cell migration, polarity, neural patterning and organogenesis during embryonic development CCAR2 SOST ROCK2 APC COIL SMAD4 F11 SKP1 ARHA NLK PMC8238150__F1 (Pro)renin receptor in the kidney: function and significance AQP2 COX2 MPEG1 LRP6 AVP PMC3691184__F5 Integrated miRNA-mRNA Analysis Revealing the Potential Roles of miRNAs in Chordomas MAX FAS NLK TNF FLNA TRAF2 MEF2C PMC2635127__F2 JNK/p38 non-Smad pathway SMAD4 TRAF6 PMC2635127__F3 Small GTPase non-Smad pathway CDC42 SMAD4 ARHA PMC2635127__F1 Erk non-Smad pathway SMAD4 GRB2 PMC11884060__F6 Map of the metabolic pathways related to the differentially expressed genes in strains S26 and S26-AE2 under 20 g/L and 100 g/L glucose conditions tal-1 GPD2 ENO2 HEL-S-68p FBP1 ENO1 GPD1 PMC2635127__F4 PI3K/Akt non-Smad pathway SMAD4 MTOR PMC8816882__F2 Programmed cell death in aortic aneurysm and dissection: A potential therapeutic target RIPK3 BAX GSDMD NLRP3 MLKL GPX4 RIPK1 TNF FADD PMC5607088__F1 AT1 receptor signaling pathways in the cardiovascular system EGF HBEGF RAF1 ADAM17 EGFR MTOR EIF4E PMC8569258__F2 Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects BAX TRADD INSR FASN BCL2 GRB2 MTOR INS TRAF2 PMC6048025__F8 Regulatory effects of androgen on TGFB1/Smad signaling pathway and Nrf2-ARE signaling pathway TGFBI KEAP1 NQO1 MMP2 PMC3514454__F7 Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo SP1 PMC3425523__F4 Genes known to cause kidney cancer and their relationship with the mammalian target of rapamycin signaling pathway RHEB TSC2 FH HGF TSC1 FNIP2 FLCN FNIP1 VHL PMC10454862__F10 S100A4 Promotes BCG-Induced Pyroptosis of Macrophages by Activating the NFKB/NLRP3 Inflammasome Signaling Pathway S100A4 GSDMD NLRP3 PMC4467434__F6 Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer TGFBR2 BMPR2 SMAD9 SKIL SMAD1 DKFZp781O1323 BMPR1A SMAD2 SMAD4 PC TGFBR1 PMC2919370__F4 Fanconi Anemia Proteins and Endogenous Stresses FANCE ATR ATRIP FANCA PMC7728580__F2 Role of H2S in HCC STAT3 EGFR MTOR PMC2757945__F9 Molecular pathways by which WNT-Beta-Catenin and FGF regulate lung mesenchymal development FGF9 CCND1 LEF1 CTNNB1 PMC9174948__F3 Chloroplast pH Homeostasis for the Regulation of Photosynthesis CYB BCAT2 BCAT1 PMC5684252__F1 An overview of signaling nexus of autophagy pathways WIPI1 LAMP2 ATG12 ULK1 TFEB BNIP3 BCL2 ATG5 PMC2663408__F15 The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification CYP2A13 AKR1C2 AKR1C1 AKR1C4 PMC4063740__F8 Regulation of Schistosoma mansoni Development and Reproduction by the Mitogen-Activated Protein Kinase Signaling Pathway EGF EGFR GRB2 PMC7874400__F7 Critical role of miR-574-5p in ARDS pathogenesis HMGB1 NLRP3 TLR4 IL1B PMC7226631__F6 miRNA networks generated using IPA (Ingenuity Pathway Analysis) for the altered plasma miRNAs in colorectal cancer NR1C1 RECK PAH PMC6715616__F1 Anti‐ and proviral roles of autophagy in plants NBR1 AGO1 REM1 PMC4868689__F7 Protein kinase D2 contributes to TNF-Alpha-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3B/Beta-catenin pathway in hepatocellular carcinoma GSK3B CTNNB1 PMC11009445__F1 Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review LATS1 LATS2 FAS RHO PMC9336466__F2 Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues LAT HEL70 REL FADD PMC7455639__F1 Genetic variant rs2494938 of LRFN2 gene is associated with non-small cell lung cancer risk in North-Indian population LRFN2 APC DLG4 PMC4690755__F6 Novel pathways of apolipoprotein A-I metabolism in HDL of different sizes in humans TG ABCG1 PLTP ABCG4 ABCA1 PMC11822051__F6 The proposed mechanism PLD2 PC MTOR PMC1413672__F6 Activation of PI3K signaling by PV HEL-S-28 PTEN MTOR PMC5423755__F1 FA/BRCA DNA damage response pathway BRIP1 RAD51C RAD51 USP1 BRCA2 PALB2 PMC3613856__F7 Association of Luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies DCP2 DCP1A EIF4E PMC12235269__F3 Fig. 3. JAK-STAT signalling pathway and JAK inhibitors in ulcerative colitis IL19 OSM LIF JAK3 EPO TPO TYK2 PMC7795031__F1 Shows how AhR ligands, such as air pollutants, FICZ, TCDD and kynurenine, including tumour derived, activate the AhR to modulate mitochondrial metabolism, partly via the regulation of the melatonergic pathway COX2 PDC AANAT AHR ASMT PMC8909928__F1 Fibroblast Growth Factor 23 and Osteoporosis: Evidence from Bench to Bedside CASR NR1i1 PTH FGF23 PMC6908928__F9 Gene network describing the possible mechanism of the regulation by CHST15 of cell proliferation and apoptosis as determined by IPA TIMP3 TGFA ILKAP USO1 LEPR CREM PMAIP1 SAE1 TPM1 PTHLH RABL6 BTG2 APCDD1 CLU BMP2 EEF1A1 CCND1 PMC9500187__F2 Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms CDK6 MDM2 CDK4 PMC6581700__F6 Molecular model for HTLV-1 and HTLV-2 regulatory proteins HBZ and APH-2 on Tax-mediated NFKB activation and TRAF3 interaction TRAF3 HBZ PMC4715896__F1 Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis COQ7 COQ3 COQ2 PMC8814816__F2 Targeting cholesterol homeostasis in hematopoietic malignancies CH25H CYP46A1 CYP27A1 MVK PMC8589410__F10 Proteomic profiling of saliva reveals association of complement system with primary Sjögren's syndrome HEL-S-62p FGA PMC3429540__F1 Emerging role of autophagy in kidney function, diseases and aging RHEB MAPK1 TSC2 TSC1 EIF4EBP1 FKBP1A RRAGA MAPK3 PMC6349439__F1 We shall overcome (drug resistance) some day STAT3 ALK EGFR PMC2909662__F1 Signaling pathways of TLR4 TLR1 TLR3 TLR4 MAL RELA IRF3 TRAF3 TRAF6 MYD88 PMC6827255__F1 DNA-driven cGAS-cGAMP-STING signaling mediates innate immune response TBK1 STAT1 CGAS STAT2 IRF9 IRF3 PMC7532048__F9 Mechanism diagram KDM5B SOX2 CTNNB1 PMC3436837__F1 Boolean network model of the HGF-induced keratinocyte migration CDC42 HGF MMP10 EGFR PLG PTEN ATF2 RAC1 HBEGF CDK2 AKAP12 CCL20 GAB2 PMC5618532__F2A Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53 BAX TSC2 ULK1 BCL2 MTOR PMC5727250__F3 Possible Wnt pathway‐related therapeutic targets in CLL ROR1 LEF1 CTNNB1 PMC6939831__F4 Three enriched Ca2+-related pathways RYR2 FLNB APC PPP2R1B SMAD4 FZD1 GRB2 PMC4661858__F3 Inhibitors developed against EZH2 EED AEBP2 EZH2 SET PMC5727250__F1 Simplified overview of mammalian Wnt/B‐catenin and Wnt/PCP pathways ROR1 APC ROR2 GSK3B LRP5 LRP6 RHO MYC LEF1 RAC1 CTNNB1 PMC4766307__F1 Recruitment and activation of bone marrow-derived fibroblasts in renal fibrosis CCL21 JAK3 CXCL16 CCL2 PMC9248407__F3 Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors TH DBP MME ATG14 AP2A2 RET SET ABCA4 PMC11052371__F3 Pathogenesis of acne and the mechanism of action of P FGF7 CD36 VCAM1 MTOR FGF10 CTNNB1 FGFR2 PMC3173801__F1 Many receptors modulate Wnt signalling PTK7 RYK CTNNB1 PMC9112182__F7 RNA Binding Motif Protein 3 Promotes Cell Metastasis and Epithelial–Mesenchymal Transition Through STAT3 Signaling Pathway in Hepatocellular Carcinoma STAT3 HEL113 MMP2 MMP9 RBM3 PMC3726314__F6 Toll-Like Receptor 4-Myeloid Differentiation Factor 88 Signaling Contributes to Ventilator-induced Lung Injury in Mice TIRAP TLR4 IRF3 TRAF6 MYD88 PMC3557433__F1 Effector intercrossing network under physiological condition UCP2 BAX TG NDRG2 MAFA SIRT1 HEL-117 PMC6467343__F1 Complications and management of coagulation disorders in leukemia patients TFPI PLG CS FDPS PMC5496628__F1 mTOR is the essential signaling pathway for nutrient sensing and apoptosis protection in the B cell TSC2 TSC1 TXNIP IRS1 PMC3384424__F1 The mTOR signaling pathway PRR5 RHEB DEPTOR PMC6679057__F2 WNT pathway molecules and their involvement in chemoresistance in NB FZD1 CTNNB1 PMC10886236__F4 Heatmap of the pathway of glycolysis, antioxidant enzymes, and ascorbate–glutathione cycle UGDH HEL-S-162eP PRX NACA PMC9206138__F2 Immunosuppressive role of indoleamine 2, 3-dioxygenase in glioblastoma: mechanism of action and immunotherapeutic strategies TH PMC5396079__F10 Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway RHEB TSC2 TSC1 ATG12 FOXO1 PMC7010219__F7 Role of DADS in leukemia cells LIMK1 ROCK1 RAC1 PMC7733924__F6 Predicted pathways might be involved in the interaction between CSFV p7 and host cells MAPRE1 PIAS1 GGNBP2 POMP PMC11707400__F5 Immune signaling pathway of infected cells TMPRSS2 CGAS TLR9 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR1 TLR4 TLR8 TLR7 ACE2 PMC6535662__F1 Various regulatory mechanisms of MALAT1 in different diabetes-related complications SP1 NLRP3 ELAVL1 CTNNB1 MYD88 PMC1190322__F10 CdGAP mediates cross talk between the Ras/MAPK pathway and the regulation of Rac1 activity TIAM1 GRB2 SHE RAC1 PMC3573943__F1 Regulation of cellular metabolism by p53 HEL-S-20 TIGAR SCO2 PDK2 GLS2 PMC4509205__F4 PI3K/AKT network in renal cancer samples MAX BAX JUN BAD NF1 MYC FOS PMC5332432__F1 Activation and control mechanisms of the human complement system CD59 FH HEL-S-62p PMC9187795__F3 CD30 Expression in Oral and Oropharyngeal Diffuse Large B Cell Lymphoma, not Otherwise Specified TRADD TAB3 TRAF5 TRAF2 PMC5618532__F1A Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53 BAX TSC2 ULK1 BCL2 MTOR PMC6359975__F2 Acquired resistance mechanisms to CDK4/6 targeting RPS6 BAD BRAF CDK2 MDM2 CDK4 PMC7349579__F2 Interactions of LCSCs influencing HCC EPCAM STAT3 CD24 SMAD2 APC LRP5 SMAD4 LRP6 IL6 CD47 CTNNB1 PMC8146608__F4 Influenza Virus RNA Synthesis and the Innate Immune Response RIPK3 TBK1 ZBP1 MAVS TRIM25 MLKL IRF3 IRF7 PMC8394812__F1 Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages CD36 TAB3 TRAF6 IRAK4 PMC2258989__F6 Schematic presentation of the signaling pathway induced by HCV core protein for insulin resistance in human hepatocytes PI3 MTOR IRS1 PMC2840099__F7 Proposed model of miR-486 regulation and function in muscle cells GSK3B PTEN PMC8699052__F2 NRF2 in Mycobacterial Infection STAT1 CCR2 SFN PMC5076847__F12 Regulation of IRF1 and IRF1-dependent late-phase gene expression by IL1B after DUSP1 silencing and glucocorticoid treatment GC IL18 IRF1 IL1B PMC8507617__F1 Hedgehog Signaling in Myeloid Malignancies SUFU SMO PMC10223558__F6 Identification of key hub genes CXCR3 TGFBI RASGRP3 NR4A3 PLA2G3 MYC CCL2 WNT5B GRB10 LOX GSTA4 MGST2 MMP3 WNT4 ADAMTS12 GRIN1 CALML3 RGS14 PLAUR INPP5D ADAMTSL1 TSPAN33 ALOX5AP TNF ANGPT2 CXCL10 CXCL14 GSTA3 IGF1 PLCB1 PCOLCE2 COL9A2 CXCR4 COL5A2 LAMA3 CXCL12 HEL113 TIMP1 IFIT1 THBS2 IGFBP1 IBSP IGFBP2 CHAD COL3A1 MYLK IGF2R ACTA2 COL1A1 LMOD1 PDGFD COL1A2 PECAM1 IGF2 CD34 ITGAM POU5F1 PRKAA2 RPS6KA5 GATA4 PMC8814816__F1 Targeting cholesterol homeostasis in hematopoietic malignancies ABCG1 ABCA1 PMC10223558__F5 Networking among differentially expressed genes (DEGs) and pathways identified via GSEA RASGRP3 MYC CCL2 PDZD2 GRB10 B3GNT6 HAO2 MMP3 LIPK GXYLT2 NRARP TNF HS6ST2 CXCL10 RAPGEF4 ANGPT2 ACOT11 GBGT1 AK8 ALDH3B2 THEM5 NRG2 CYP2S1 GSTA3 PDE9A CHST5 GSTM1 TMLHE FOSL1 PLCB1 B3GNT8 PIGR COL8A1 PTK6 SGPP2 COL3A1 LPAR4 BAAT RASAL1 CRIP3 ELF5 HEL-S-134P MUC13 TNLG1B CYP17A1 KPRP NKD2 EIF5 ARG1 IGF2 RORC ACSM3 CADM1 HHIP CARNS1 HS3ST3A1 NFATC2 NR4A3 PLA2G3 FN3K WNT5B GSTA4 ALOX12 WNT4 GRIN1 FHIT PYGM RGS14 PGLYRP1 AMPD1 SORD INPP5D PIK3AP1 ALOX5AP ALAS2 GPD1 ACSS1 BMP6 COL9A2 LAMA3 HEL113 HACD1 CHRM1 EGFR XPNPEP2 THBS2 IFIT3 IBSP CHAD MGAT5B MYLK SAA2 PDGFD PDE7B AOX1 CEACAM1 COL1A2 PDE5A ITGAM MALL NMUR1 PRKAA2 RPS6KA5 CISH PMC10223558__F8 Expression analysis of genes involved in PI3-AKT-mTOR pathway post MMTV expression SYK BAD RASGRP3 PTEN MTOR MYC COL1A1 BCR TLR4 WNT4 MDM2 CCND1 CASP9 PDGFD COL1A2 RBL2 CD19 ANGPT2 RAC1 IGF2 IRS1 RHEB TSC2 TSC1 IGF1 BRCA1 CDC37 GRB2 PMC5850946__F7 Ras signaling cross-talk protein transport ETS2 FUT2 PML FGF6B TRAPPC6A VAMP7 FGFR2 TMED10 TSC2 PDGFRA FGFR4 YKT6 RPN1 SHH STX4A COG2 KDR GRB2 PMC7990793__F2 Differences of inhibitory effects between homodimeric and heterodimeric IL-35 EBI3 STAT4 JAK1 TYK2 PMC6214138__F2 Canonical FLT3 and mutant FLT3 signaling pathways FLT3 BAD PTPA LYN MTOR SHE PMC4484229__F5 Serum C1 competes with Wnt for Fz receptor binding, resulting in Wnt canonical pathway activation APC LRP5 LRP6 CTNNB1 PMC6499694__F7 Working model of how the spatial distribution of nuclear DNA damage and extracellular neurotrophic factor signaling coordinates AKT-mTORC1 activation RHEB NGF PHLPP1 ATM PMC11449287__F12 D2O on expression levels of cellular genes involved in “TNF signaling pathway” and “p53 signaling pathway” BAX MAFK AIFM2 CYC1 PTEN TNF MYC TSC2 PIR CDK2 ATM MDM2 CDK4 PMC4111749__F2 Regulation and roles of Cdc7 kinase under replication stress RAD18 FANCD2 RAD51C POLN PMC5850946__F5 PI3K-Akt signaling and Ras signaling pathways HRAS TSC2 PRKCI FGFR4 PPP2R3A FGFR3 PTEN KDR GRB2 CCND1 YWHAZ FGFR2 PMC7068268__F3 Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer CIC PMC6468621__F3 Lung adenocarcinoma treatment and emerging therapeutic potential of targeting macrophages CXCL12 MARCO CCL2 PMC7530006__F2 Schematic Indicating Common Pattern Recognition Receptor (PRR) Pathways Used by Immune Cells to Recognize Danger Signals SAP130 SYK TBK1 CGAS MAVS TLR9 AIM2 TLR5 IRF3 RAC1 MYD88 TLR1 NLRP3 TLR3 TLR4 FPR1 TLR8 TLR7 IL1B PMC5438623__F7 Screening effective differential expression genes for hepatic carcinoma with metastasis in the peripheral blood mononuclear cells by RNA-seq JUN MMP9 IL1B PMC4773219__F6 Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy TES TH MOB2 UBC SPTBN2 PARS2 MMACHC RALA ZNF362 CSMD3 METTL1 C2 CTNS MUTYH ZNF2 SUMF2 CST4 MAP7D1 EEFSEC MTR PMC4773219__F4 Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy UBC MAML2 PMC9247483__F2 Current Understanding and Management of Plasma Cell Mastitis: Can We Benefit from What We Know? STAT3 PRL SOCS2 MTOR TNF GHR PMC9000380__F1 Ferroptosis: A New Road towards Cancer Management GPX4 LPCAT3 FACL4 HEL-75 PMC545204__F3 Retinoic Acid and Arsenic for Treating Acute Promyelocytic Leukemia FLT3 RARA COX1 PML PMC9063252__F8 Effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy AAK1 ACE2 HDAC2 PMC11046879__F2 Illustrates the functions of PTEN in the cytoplasm and nucleus RAD51 MVP PTEN MTOR CENPC MCM2 RPA1 PMC8188603__F7 Network Pharmacology and Molecular Docking Study on the Potential Mechanism of Yi-Qi-Huo-Xue-Tong-Luo Formula in Treating Diabetic Peripheral Neuropathy PC APP HEL-S-11 TNF PMC3507431__F2 Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy PTEN MTOR SRC SIRT1 PMC7273913__F1 Characterization of FANCL variants observed in patient cancer cells FANCD2 FANCL UBE2T PMC7527441__F1 Major immune response pathways after helminth infection IL25 MUC5AC TSLP IL33 ELL ARG1 AREG PMC8405290__F5 Exploring the Mechanism of Action of Herbal Medicine (Gan-Mai-Da-Zao Decoction) for Poststroke Depression Based on Network Pharmacology and Molecular Docking PLB1 PPARG STAT3 PPP3CA CCNA2 MYC CCL2 POR RB1 BCL2L1 MTTP DRD4 PRKCA MMP2 MMP3 MDM2 UGT1A1 PYGM CASP9 SLPI MMP10 HK2 DUOX2 VEGFA TNF CXCL10 FOS CXCL11 GSTM1 HMGCR CHRM2 HAS2 CDK2 BCL2 ADRB1 HEL-75 HEL-S-22 BAD CHRM1 EGFR F7 NR1C2 ACACA MAP2 RUNX2 COL3A1 NCF1 RORA MPO ABAT CHRNA2 COL1A1 F3 HSF1 CHEK2 IL18 LDLR AHR CHUK APP ABCG2 CCNB1 CCND1 CDK4 CYP1A2 ACHE BAX JUN SELE FASN CXCL2 BACE2 MMP9 PTGS2 CYP1A1 IGF2 SPP1 NR3C2 NR1C1 HEL-S-130P PSD IKBKB RELA HEL-S-102 PTGES CYP3A4 PMC7990793__F4 Potential working model of IL-35 immunepathogenesis in chronic HBV infection EBI3 STAT4 JAK1 TYK2 PMC1236700__F2 Regulation of the extrinsic pathway by Hsps BAX BAD TRADD BCL2 BMF TRAF1 CDC37 TNF TRAF2 FADD PMC5353654__F7 Series of functions (e.g TRH FGA PMC5260050__F2 Pathway map for selected proteins encoded by genes that were upregulated in baseline systemic juvenile idiopathic arthritis (SJIA) samples STAT1 JUN IRAK1 IRF1 TRAF6 MYD88 PMC5593568__F7 IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NFKB pathway and reduction of JNK in HNSCC CXCR1 NOD1 IL8RB PMC9394511__F9 Schematic model illustrating the PI3K/AKT pathway associated with CCRL25/CCR9-induced malignant biological behavior in SACC BAX CCL25 BCL2 CCND1 PMC5908625__F2 Identification of genes related to consecutive trauma-induced sepsis via gene expression profiling analysis WDR82 EPHB4 PCF11 UBE2C ARPC2 WASL EPHB6 CENPE TYMS BLM ACTR2 EFNB1 SF3A1 PRPF6 PTBP1 PAPOLA PFN2 CPSF1 WIPF2 GTF2F2 ITSN1 EFNB3 PMC11648720__F8 Schematic diagram shows that two residues change in SARS-CoV-2 N protein trigger NFKB inhibition TMPRSS2 MAVS TRADD C2 TAB3 TRAF5 IRAK1 RIPK1 TRAF6 TRAF2 IRAK4 MYD88 PMC3120937__F1 Signalling pathways in oesophageal adenocarcinoma EGFR APC LRP5 LRP6 MTOR CTNNB1 PMC4969253__F1 Retinoid regulation of early lung development ACTA2 DKK1 FGF10 PMC8618769__F2 Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases ABCG1 ABCG8 ABCG5 NPC1L1 BACE1 ABCA1 PMC6562528__F7 PyCyp protein effects on EGFR signaling in IEC-6 cells EGFR CDK2 GRB2 PMC8618769__F5 Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases ACHE BACE1 APP BCHE PMC7952444__F4 Aberrant expression of PIWIL1 mediates tumorigenesis and progression CDH2 BMI1 PIWIL1 PTEN MTOR PMC4763541__F7 Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation PTCH1 SHH PC SMO PMC6563508__F5 Cytosolic recognition of foreign nucleic acids and activation of interferon stimulated genes (ISGs) TBK1 STAT1 MAVS STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IRF7 ISG15 TYK2 PMC6357196__F5 Proposed chemoresistance mechanism mediated by RAB7A CD81 RAB7A CD9 CDS1 CD63 PMC6325590__F6 Leptin signaling modulates appetite through primary cilia STAT3 ADCY3 LEPR POMC MC4R AgRP PMC3929886__F8 Model for JMJD2B silencing on tumour suppression through DNA damage STAT3 ATR ATM PMC6325590__F8 Mechanisms underlying the loss of primary cilia frequently observed in cancer cells with aberrant RTK USP43 PMC11942745__F3 Putative schematic representation of the mTOR signaling pathway in APS RHEB MLST8 TSC2 TSC1 DEPTOR PMC8809118__F7 NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria ATF3 TCF3 KEAP1 TCF4 ATF4 LEF1 NOX4 SIRT1 PMC12093350__F1 P2X7R in Retinal Diseases: A Review CD40 GSDMD NLRP3 PMC5023632__F9 Possible mechanism for cross talk between P2X7 nucleotide receptor and canonical Wnt signaling pathways in cells of the osteoblast lineage WNT3A GSK3B CTNNB1 PMC8834850__F2 Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma STAT3 BAX STAT1 ATF2 PMC6268005__F2 ERAD regulation of cholesterol metabolism UBIAD1 UBE2G2 HMGCR VCP PMC8834850__F3 Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma MAX STAT1 RARA ATF1 ATF2 HMGN1 MYC PAX6 PMC3404840__F1 HIV pathogenesis and T-cell signaling by HIV-1 Nef FAS TRADD CCR5 TRAF1 CXCR4 TRAF2 FADD PMC3404840__F2 Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef CD40 APC LCK PMC8895153__F3 SUMOylation in Viral Replication and Antiviral Defense TBK1 TRIM38 TRIM28 MAVS TOPORS SENP1 IRF3 IRF7 SENP2 PMC8687743__F2 HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer ATAT1 HSF1 VCP HDAC6 PMC8895153__F4 SUMOylation in Viral Replication and Antiviral Defense TBK1 SUMO1 TRIM38 SUMO3 CGAS IRF3 SENP2 SENP7 PMC4614078__F9 Updated model showing the role of AMPK-HDAC5 in HIF-1 activation as a response to hypoxia IPP HDAC5 VHL PMC6073502__F4A Time Dependent Pathway Activation of Signalling Cascades in Rat Organs after Short-Term Hyperoxia MGST3 ST13 STAT3 MEP1A RAB1A SLC34A1 HEL-S-269 CYC1 NUMB TAP1 HEL20 HEL-S-100n GDA GNAS ACAT1 RARA SUMO3 HEL-S-2a HEL-S-5 COX4I1 HEL-S-32 MDH2 HEL-S-165mP TUBA1A SERP1 RPLP0 GDI2 RSF1 RPSA SNCA MIF hEMMPRIN ACTR3 ALDOB STOML2 PPP2R2A FBP1 HEL-S-102 ENO1 PMC2964899__F1 Schematic representation of the molecular events associated with cellular processing, lipid modification, and secretion of the SHH protein and the autocrine and paracrine actions of mature and secreted SHH protein PTCH1 SHH SMO PMC5761609__F3 Activation signals of inflammasomes NLRP3 TLR4 IL1B PMC2964899__F3 Molecular events associated with the repressive effect induced by PTCH1 receptor on the SMO activity and the activation of the Hh signaling pathway mediated by the SHH protein in the primary cilium SHH SMO PMC5646344__F1 Domain structure of Sina/Siah and its regulation in Drosophila and mammals DYRK2 ATR ETS2 SP1 SIAH2 HIPK2 ATM TWIST1 PMC2964899__F5 Cellular events and signaling elements involved in the regulation of SHH expression, GLI activation, and mediation of the Hh activation-induced cellular response EGF EGFR PDGFRA SHH IL1A CTNNB1 RORA PMC8226934__F2 Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling CBL FGFR3 TSG101 PMC2964899__F6 Scheme showing the signaling elements and frequent deregulations in the Hh signaling network and potential cross-talk with the EGFR signaling pathway involved in the malignant behavior of cancer cells HHIP SHH SMO HP PMC7360675__F1 Extracellular and intracellular regulatory mechanisms of HLA-G expression CSF2RA HLA-G IRF1 PMC8226934__F1 Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling TF FRS2 GRB2 MTOR GRB14 PTPRG PMC8904974__F8 Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition HRAS NRAS GRB2 PMC10036181__F4 Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease SOST DKK1 LCN2 FGF23 PMC10888037__F8 Schematic diagram showing the potential pathways which were more active in non-mucilage BS SDHA RFC2 OGDH FES MCM5 DLD MCM6 CS RFC3 MCM2 PMC5694782__F1 Critical DDR Pathways for UV induced DNA Damage: (1) UV induces an intrastrand lesion, causing the replication fork to stall in S-pase TOPBP1 ATR ATRIP RAD51 PCNA BRCA1 BRCA2 ATM POLE POLN PMC7937872__F7 Proposed resisting the excitability toxicity signaling pathways triggered by ICT in ischemic neurons EGF EGFR GPER SRC PMC6036739__F7 The positive feedback of CCL2 and SQSTM1 contributes to chemoresistance CCR2 SQSTM1 MTOR CCL2 PMC5393948__F6 Isl1 conditional mutants are deficient in Foxo signaling ISL1 BACH2 FOXO1 FOXO3A FOXO6 PMC2601639__F1 Membrane Recruitment as a Cancer Mechanism: A Case Study of Akt PH Domain C2 PTEN PMC10743075__F9 N-3-PUFAs decreased mRNA expression of key enzymes of fatty acid biosynthetic pathway FH HEXA FASN FES PMC6550088__F2 Focal adhesion pathway (A) and HIF-1 signaling pathway (B) altered in a CRC CDC42 TH MAFK BAD VASP HEL-S-133P ZYX HEL-S-28 PTEN SHE LAMB1 FLNA DOCK1 RPS8 HEL114 HEL-S-68p HEL-S-162eP MYL12A RAP1A ITGA6 ENO1 PMC8047536__F3 Intracellular interferon signalling pathways as potential regulators of covalently closed circular DNA in the treatment of chronic hepatitis B ISG20 PRMT1 LTBR SOCS2 IFI16 SOCS3 CP PMC8450407__F3 TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease STAT2 IRF9 TLR9 IRF1 IRF3 IRF7 IRF4 IRF8 TRIM21 STAT1 IRF2 JAK1 TYK2 PMC2427336__F9 A schematic summarizing ER stress response pathways in cells compensating for deficiency of the ER stress response kinase, PERK ATF4 XBP1 PMC5355696__F3 Signaling pathway networks RHEB RICTOR PXN NFATC2 NFATC1 MAPK12 KDR SRC KRAS PMC7527241__F7 Serum discrimination and phenotype assessment of coronary artery disease patents with and without type 2 diabetes prior to coronary artery bypass graft surgery FBN3 KIF13B THSD7B MALRD1 HSPG2 MUC17 DNAAF2 CACNA2D2 DNAJC5 HERC2 INHBB TTN ANKRD17 FBN2 CUBN BAT2L VWF SPG11 CORIN DPYD NOTCH2 SYNE1 RELN CSMD2 XB NUP153 MUC5B SCUBE1 MUC2 PMC5223280__F5 Growth Arrest-Specific 6 (GAS6) Promotes Prostate Cancer Survival by G1 Arrest/S Phase Delay and Inhibition of Apoptotic Pathway During Chemotherapy in Bone Marrow CDK2 CDK4 PMC5688152__F7 Schematic overview of metabolic pathways of P ABAT DIO1 GLA ACD CS PMC10513393__F5 Cytokine-mediated signaling in T-cell lymphoma metabolic reprogramming IL21R MTOR IL23R PMC7827558__F1 Schema of the new arm of the DNA damage signaling pathway (DDR) SRSF7 CDYL BCL6 RPL26 SIRT1 PMC8798197__F5 Increased efficacy of gefitinib on cisplatin-resistant wild-type epidermal growth factor receptor non-small cell lung cancer cells RHEB TSC2 BAD TSC1 EGFR PMC7830477__F7 Proposed mechanisms of the antioxidative actions of Pistacia lentiscus var HEL-S-22 HMOX1 GPX1 HEL-75 HEL-S-44 PMC4797633__F1 Complement system CD59 C4A CR1 PMC8861859__F7 Wheat oligopeptides enhance the intestinal mucosal barrier and alleviate inflammation via the TLR4/Myd88/MAPK signaling pathway in aged mice TLR4 IL1B MYD88 PMC3603280__F1 SLC41 family of MgtE-like magnesium transporters MGA TRPM7 SLC41A2 PLCG1 MAGT1 SLC41A1 PMC9755961__F3 Heterogeneity of neutrophils in cancer: one size does not fit all TRPM2 HGF SIRPA ARG1 CD47 PMC11967956__F7 Summary scheme of the obtained data MTOR VEGFA PMC6058924__F6 Pathway Studio Analysis of Proteomic Content of TFMPs at 6 Months in the Infarcted Groups Compared With Control Group Profile(A) Heat shock proteins (HSPs) associated with post-ischemic conditioning detected in CRT+BB–treated animals only ATP1A1 PMC12006078__F6 Potential mechanisms of acacetin in preventing DCM and drug-induced cardiotoxicity BAX DGAT2 SIRT1 PMC7343503__F6 Resveratrol regulating MARCH1 expression STAT3 BCL2 PTEN PMC3943763__F1 Toll-like receptors in antiviral innate immunity TBK1 MAL TANK TLR9 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC12006078__F4 Mechanisms of action by which acacetin prevents cardiac fibrosis and hypertrophy NR1C1 SMAD4 MTOR SIRT1 PMC8580935__F1 Palbociclib as an early-line treatment for Japanese patients with hormone receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer: a review of clinical trial and real-world data SPOP MTOR PMC5572374__F2 Prior knowledge network (PKN) derived from public resources, including interactions connecting nodes which are measured (in blue) or perturbed (stimulated in green and inhibited in red) in the experimental data RPS6 STAT3 EGF IGF1 EGFR IGF1R IL6 MTOR MYC PMC9684205__F1 Emerging roles of fibroblast growth factor 21 in critical disease FRS2 FGF21 GRB2 PMC12006078__F3 Major signaling pathways of acacetin in protecting against endothelial injury and improving atherosclerosis SIRT3 SIRT1 ARG2 PMC4094296__F3 Pathogenetic Importance and Therapeutic Implications of NFKB in Lymphoid Malignancies STAT3 SYK BTK BCL10 BCR CARD11 IRAK1 MTOR JAK1 IRAK4 MYD88 PMC4560668__F1 WNT signaling in adult ovarian folliculogenesis CTCF APC CTNNB1 PMC4560668__F2 WNT signaling in adult ovarian folliculogenesis APC AXIN2 CTNNB1 PMC10312928__F5 Protein-protein interaction network and functional enrichment analysis of proteins with acetylation, carbamylation and phosphorylation sites regulated by bacterial lipopolysaccharide ABCE1 DDX5 KMT2C MYB HEL113 RANBP1 ANXA2 BAZ1B HAMP RPS27 USP14 DDB1 ACTN4 PLEC EIF4A1 HEL-S-87p CAP1 LMNA PMC3163125__F1 Complement system: the classical complement pathway involves a sequentially acting multistep cascade in which the complement components C1q, C1s, C1r, C4, C2, and C3 play important roles C6 C7 C9 C4B_2 PMC11529338__F5 Bone microenvironment of prostate cancer with bone metastasis TGFBR2 CSF2 METTL3 PTH1R RBM3 CTNNB1 PMC12249962__F2 Key metabolic pathways, transcriptomic modulation, and chemotherapeutic and metabolic compounds for prostate cancer treatment TF HIF1A PMC12249962__F3 Multi-target promising compounds for prostate cancer (PCa) treatment ACLY ACSL1 HEL-S-133P HK2 FASN PMC9318110__F1 New Insights into TRP Ion Channels in Stem Cells OTX2 FGFR1 TRPC1 TRPC5 TRPC6 TRPC3 PMC9318110__F2 New Insights into TRP Ion Channels in Stem Cells STAT3 TRPM7 SMAD1 TRPM2 NFATC1 HEL-S-11 SP5 CTNNB1 PMC12170767__F4 Process Diagram BPIFB4 CS PMC8197496__F2A Survival-Critical Genes Associated with Copy Number Alterations in Lung Adenocarcinoma BARD1 IFNG ATR RAD50 ATRIP MRE11A BRCA2 ATM ATF1 BLM PMC2773962__F6 Model of Tbx2 function for the EC formation in the AVC TBX2 BMPR1A BMP4 BMP2 HAS2 PMC10222578__F5 Networks of interactions between the genes affected by the production of sfRNA in ZIKV infection of human brain organoids RAB43 MDK PRMT6 MCL1 PAX7 NGF SLC4A10 MBD4 COPS6 CHAF1B JUNB PERP VEGFA TNFRSF10D BAG3 CDKN1A MCM10 APOB OSR1 MRGPRD SESN2 EGR2 MYDGF DLG2 FAS EBP CXCL1 TMX1 TASOR BSND PCDHA2 H1-1 ADAMTS20 SLC16A11 CRYGC DCX CCND2 RARB POU4F1 F3 ACVRL1 CDK4 ADGRA1 CCND3 GAL HIST1H2BE HTATIP2 KRAS CA11 PARP3 HP TMOD2 HEL-S-87p LEF1 PMC1480599__F7 Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb-uPA Mouse Model: Role of the Innate Antiviral Immune Response IFNG IFNGR2 IFNGR1 STAT2 IRF9 IRF3 IRF7 JAK1 TYK2 PMC10222578__F6 Interconnection between sfRNA-affected biological processes in ZIKV-infected human brain organoids RAB43 DLG2 EPHA2 MED4 STAB1 PTEN HTATIP2 KRAS FAIM PAX7 SCRG1 WLS CA11 PPBP CCND2 DPF3 F3 PARP3 SMO EGR2 MRGPRD CCND1 USP16 MYDGF PMC4086339__F5 Deregulated focal adhesion pathway in NSCLC cell lines MAPK1 HEL114 VASP FLNB ACTN4 CRKL ARHA MYL12B FLNA PS1TP5BP1 PMC11529338__F3 Osteoclast-mediated bone resorption reactivates dormant tumor cells CDH2 DKK3 CXCL12 TBK1 BMP1 LIF ROR2 BMP7 MTOR CXCR4 PMC9439914__F2 Biological Mechanism on SIRT1/NLRP3/IL-18 Signaling Pathway of Acupuncture for Treatment of Ischemic Stroke with Center Poststroke Pain DEK HAL MAK ARX PMC10531003__F2 Pathway from Acute Kidney Injury to Chronic Kidney Disease: Molecules Involved in Renal Fibrosis PLG TRPC6 CTNNB1 PMC9699238__F8 Fascaplysin Induces Apoptosis and Ferroptosis, and Enhances Anti-PD-1 Immunotherapy in Non-Small Cell Lung Cancer (NSCLC) by Promoting PD-L1 Expression BAX GPX4 BCL2 SLC7A11 ATF4 PMC3538603__F8 Neural Stem Cell Death, Survival, and Differentiation in Response to Partial FGF-2 and EGF Deprivation CDC42 PRLR TH LEP OXTR SCTR TSHR TACR2 NRP1 ROBO1 PRLHR ROBO2 LTB4R LPA FYN RHOD RND1 GHR DCC LEPR ARHA HRAS GNRHR PRL FES PMC4941544__F2 Overcoming the matched-sample bottleneck: an orthogonal approach to integrate omic data BAX CASP9 MSH6 JUN DCC BAD SMAD2 APC SMAD4 RHO TGFBR1 CTNNB1 CASP3 PMC4941544__F3 Overcoming the matched-sample bottleneck: an orthogonal approach to integrate omic data STAT3 EGF BAD BRCA2 SMAD4 RALBP1 TGFBR1 PMC8400927__F10 Cell communication analysis results for integrated choroid plexus and brain parenchyma cell types VIP NRGN SV2C SST PMC8834222__F1 Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile ELOVL2 CERK NFATC2 SCD FASN PCYT2 ACACA ACACB PLIN4 GPAM DGAT2 ADFP IL1B PMC7892499__F2 Strategies for antagonizing NLRP3 pathway myocarditis-related key inflammatory components NLRP3 S100A8 NOD2 S100A9 PMC6074871__F1 Synopsis of intratumoral cholesterol metabolism PCSK9 CYP17A1 HMGCR SCARB1 SQLE LDLR SOAT1 SREBF2 ABCA1 PMC5834268__F3 Identification of prefrontal cortex protein alterations in Alzheimer’s disease ZAP70 CD36 AMBP IL34 KRT4 FURIN MAPK8 EPHA1 FGFR2 SERPINA4 FTH1 MBL2 BTK FTL SSTR2 DDIT3 APP MICB CALCA LAG3 CD6 PMC2673422__F6 Hypoxia-invoked response of the glycolysis gene network ACYP1 ENO2 HK2 PGAM1 ACYP2 PGAM2 ALDOB FBP2 HEL-S-68p PFKP HEL-S-49 HEL-S-162eP FBP1 ENO1 GCK PFKL HEL-S-87p PFKM PKLR PMC7330112__F5 Resistance-associated BTK (C481) mutation and possibilities of its overcoming in ibrutinib-treated CLL patients SYK BTK BCR PLCG2 BLNK BCL2 CD19 LYN MTOR PMC6205057__F8 The Potential Schematic Diagram of the Effects of CPE on the Beta Cell and Liver Tissue TG NR1C1 MLXIPL IL1B PMC10474200__F4 Interconnectivity between prioritized high confidence transcription factors PHF19 CTSW ADM AXL STAT2 PGR LIF IRF1 EZH2 IGFBP2 IRF3 MIF TNF RHOU ARHGDIB DLK2 RPS3 PRL RELA MFN2 STAT4 CXCR4 PSME2 BIRC3 PMC10474200__F5 Prolactin signaling pathway SOCS1 NMI EBP ARHA RHO SHE GHB3 RAC1 HRAS TEC STAT1 NEK3 MAP2K2 GRB2 PMC5179551__F1 Insulin signaling pathway: intracellular insulin signaling is initiated by insulin receptor tyrosine kinase activity leading to the activation of both the PI3K-Akt pathway and the MAPK pathway BAD GSK3B GRB2 PMC9111174__F8 Transcriptome Analyses of Chicken Primary Macrophages Infected With Attenuated Salmonella Typhimurium Mutants TLR1 IL10 IGF2BP1 TLR3 IL18 IRF3 IRF7 NOD1 TLR7 IL6 IL1B MYD88 PMC8277916__F4 Computational Drug Repurposing for Alzheimer’s Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies GSK3B IL6 IL1B PMC9128211__F1 Biology of YAP in programmed cell death TRPS1 TIAM1 NLK SRC MYC OTUB2 RUNX3 PMC8277916__F5 Computational Drug Repurposing for Alzheimer’s Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies KEAP1 MAF TNF MEF2D PMC10572622__F3 Representation of part of phenylpropanoids and oleuropein biosynthetic pathway in olive fruits tmp_locus_29 TNLG7C PMC10865529__F5 Phenolic metabolic pathways and associated network diagrams CAD CCR5 CCR2 CCR4 CCR8 PMC6294171__F2 Canonical and non-canonical inflammasome signaling pathways.Notes: The figure describes both the canonical and non-canonical signaling pathways involved in the activation of different inflammasome components including NLRP1, NLRP3, NLRC4, and AIM2 NLRC4 NLRP1 GSDMD NLRP3 AIM2 IL1B PMC7460640__F3 Sex-related signaling pathways in aortic valve fibro-calcification STAT1 HEL-S-62p MGP SMAD2 BMP2 RUNX2 PMC3665348__F8 Summary of differential metabolism of procainamide in humans and mice CYP1A1 PMC7330112__F1 B-cell receptor (BCR) signaling pathway and BCR inhibitors SYK BTK BCR PLCG2 BLNK BCL2 CD19 LYN MTOR PMC4491511__F1 In response to diverse biological stressors, macrophage migration inhibitory factor (MIF) is secreted from preformed intracytoplasmic pools CD44 CD74 MIF PMC8450361__F1 Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management IGF1 MTOR SIRT1 PMC9581181__F2 Ion channels as a therapeutic target for renal fibrosis TRPM7 ORAI1 NLRP3 SMAD2 TRPV1 MTOR TRPC6 PMC2432084__F9 p27Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells GSK3B CDK2 SKP2 PMC3083340__F3 Top network affected by MAA CDH2 STAT3 CASP9 BAD CASP8 CD82 IQGAP1 IGF1R FOS HEL-S-34 RB1 BCL2L1 ITGB1 CASP3 ITGA6 LYN TNFSF10 LAMA3 PMC6008335__F1 Synthetic biology-inspired genetic circuits for caffeine-induced gene expression STAT3 IL13RA1 PMC4608393__F1 Schematic view of the LPS-mediated NFKB pathway TIRAP TRAF6 MYD88 PMC4990292__F1 Colorectal tumorigenesis in proximal/whole-colon and distal serrated polyposis APC BRAF HP KRAS MGMT PMC3731936__F5 Sequestration-induced loss of protein C receptors links coagulation, inflammation, and endothelial permeability TF VWF APC PC IL6 MMP9 TNF PMC6038710__F3 Hypothetical model for the role of lncRNAs in rheumatoid diseases IL-21 CXCL9 STAT3 CASP9 CGAS CASP3 CST1 IRF3 STAT4 CXCL10 PMC11922731__F8 This graphic illustrating the role of the CXCL2/CXCR2/Jun signaling pathway in microglia-neuron crosstalk in SAE JUN TFRC CXCL2 PTGS2 IL8RB PMC3983570__F3 Tau Acts as a Mediator for Alzheimer's Disease-Related Synaptic Deficits CDK5 FYN BACE1 GSK3B PMC3787041__F5 Live Attenuated Rev-Independent Nef¯SIV Enhances Acquisition of Heterologous SIVsmE660 in Acutely Vaccinated Rhesus Macaques CHD2 CXCL9 NBR1 HGF CCL3 CCR5 CCR3 RARRES2 IF2G CCL14 TFAM IFNK RAF3 ADFP HLA-A PMC3176897__F1 Summary of fatty acid and glucose metabolism LPL CD36 HEL-S-5 PMC1456973__F6 Aspartate and aspartate transport in the pathway of prostate citrate production MAL CS CIT PMC8262608__F1 Interleukin-1- Receptor Kinase 4 Inhibition: Achieving Immunomodulatory Synergy to Mitigate the Impact of COVID-19 TLR1 TLR4 IL33 TLR8 TLR5 TLR7 TRAF6 IRAK4 MYD88 PMC8220219__F1 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer LATS1 LATS2 PMC9138541__F9 CAST as a Potential Oncogene, Identified by Machine Search, in Gastric Cancer Infiltrated with Macrophages and Associated with Lgr5 FZD5 CAST WNT3A FZD7 FZD9 WNT2B SFRP1 FZD8 LZIC WNT1 WNT3 FZD1 GPR49 PMC8220219__F2 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer DKK1 APC GSK3B LRP5 LRP6 EZH2 TCF4 CTNNB1 PMC4103865__F2 Integrating Genomics and Proteomics Data to Predict Drug Effects Using Binary Linear Programming BAD FAS INSR EEF2 FOS PMC8220219__F3 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer FUS ANGPTL4 KIF26A EZH2 WDR5 PMC7512049__F8 Key network of “drug-component-target-biological process- signaling pathway” (P < 0.05) STAT3 BCL2L1 F2 EGFR CASP3 FPR2 BDKRB2 MPO PMC8220219__F4 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer ATF3 MTA2 SMAD2 PMC4248707__F2 mRNA decay pathways in the cytoplasm DCP2 PAN2 XRN1 PMC11897526__F1 Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway IL19 TYK2 PMC11897526__F2 Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway STAT3 STAT4 TYK2 PMC11868397__F7 Pattern of USP35 negatively regulates the MAVS signaling pathway to attenuate type I interferon production USP35 TBK1 MAVS IRF3 PMC6188467__F1 RNA-seq analysis revealed that LECs exhibit a highly perturbed cytokine–cytokine receptor pathway at 24 hours PCS IL20RB PRLR FLT3 LTA FAS LEP CXCL3 IL-21 MPL IFNK INHBB INHBE FLT4 PI3 TPO KDR AMH GHB2 IL9 LEPR IL4 IL20RA TNF LTB PRL BMP2 IL6ST EDAR TNLG7C PMC7653775__F7 An overview of homocysteine metabolism and the transsulfuration pathway PEMT CTH ChAT PMC9472369__F4 Effect of Nrf2 deletion on the proteomic signature in a human colorectal cancer cell line HEL-S-22 HEL-S-21 HEL-S-53e SLC25A10 LOC51064 C7orf24 MGST1 GGT7 GPX1 GPX8 GSTM4 HMOX1 GPX2 GSTM1 GSTM3 GSTA4 MGST2 GCLC HEL-S-64p TXNRD2 PMC5343002__F3 Adipose tissue pathways regulated by sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs) based on current literature in mouse models, adipocyte cell lines and human studies SIRT3 SIRT7 SIRT4 NAMPT SIRT2 SIRT1 PARP1 SIRT6 PMC3461631__F2 Signaling cascades mediated by plexin-A and plexin-B, and their crosstalk with oncogenic pathways in gliomas FYN ERBB2 PTEN RAC1 PMC5343002__F2 Cellular NAD+ biosynthesis and consumption processes NAPRT NMNAT1 NAMPT NMNAT2 NMNAT3 PMC3203685__F1 Summary of the Proceedings from the 10th Annual Meeting of Molecularly Targeted Therapy in NSCLC RHEB TSC2 RICTOR EIF4E PMC3436276__F7 Model illustrates proposed two pathways of regulation of S100A4 mediated by HBXIP S100A4 STAT4 PTEN PMC4810272__F6 3Cpro from different picornaviruses suppress the immune response TBK1 MAVS TLR3 IRF3 IRF7 TRAF3 JAK1 TRAF6 TYK2 KPNA1 PMC7608146__F8 Wnt signaling and Loxl2 promote aggressive osteosarcoma WLS EGFR ALOX12 ZEB2 WNT9A WNT7B PMC10147314__F5 NAE inhibitor MLN4924 has utility in the treatment of lung cancer MLN UBE2F MTOR PMC8867675__F2 Integration of liquid biopsy and pharmacogenomics for precision therapy of EGFR mutant and resistant lung cancers STAT3 HGF EGFR MTOR PMC10147314__F3 Several signaling pathways are closely related to NEDD8 PPIB PTEN MDM2 MTOR PMC10147314__F4 Several signaling pathways are closely related to NEDD8 LATS1 LATS2 CUL7 EGFR UBE2M VHL PMC3535349__F1 Iron homeostasis in absorptive enterocytes, macrophages, erythroblasts, and hepatocytes and its routes of circulation in the organism TFR2 HEPH FES PCBP1 HFE PMC10147314__F2 NEDD8 regulates the ubiquitin-proteasome degradation pathways related to CRL and MDM2, and it realizes the regulation of proteins by promoting the NFKB, PI3K/AKT/mTOR, Hippo-YAP and receptor tyrosine kinase signaling pathways NEDD8 EGFR PTEN MDM2 MTOR VHL PMC10854597__F8 FAK signaling in FLNC cardiomyopathy PHLPP1 PDGFRA PMC3535349__F2 Iron transport across the placenta (syncytiotrophoblasts) TFR2 STEAP3 FES PCBP1 HFE PMC2934865__F2 Hypothetical model for SUMO regulation in NFKB pathway TRADD TRAF6 FADD MYD88 PMC3501082__F7 A model to depict Tollip cooperating with Smad7 to mediate degradation of the TGFB receptor complex TBR1 C2 PMC8312177__F1 Analysis of the association and predictive value of hyperhomocysteinaemia for obstructive coronary artery disease HEL-S-61p PMC8773597__F2 Nrf2-Related Therapeutic Effects of Curcumin in Different Disorders BAX NLRP3 KEAP1 BCL2 MTOR PMC10876703__F7 TEAD1 promotes the fibroblast-to-myofibroblast transition during TAC or Ang-II-induced pathological cardiac remodelling through the Wnt signalling pathway BRD4 WNT4 CTNNB1 PMC9312505__F12 Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation STAT3 IL6 PMC3655322__F4 Diagram showing some of the downstream elements of the proposed Hippo pathway FOXM1 CCND1 CDK4 PMC11048214__F5 IPA canonical pathway analysis in genes containing prioritised variants BAX GLS MAL AIP DBT PCCB MIF HEL-S-51e PDHX C21orf57 CDR2L APP CLPX EPHX2 PMC10970167__F1 The protein interactome of PDE4A, B, C and D with their interconnecting protein neighbors GSC2 PCNA GSK3B MEOX2 ZBTB1 CASP6 FYN COX2 AKAP6 COIL MDM2 SRC OPTN JUN MEOX1 ARRB2 ATOH1 AIP PAX6 FOS LAMP2 TRAF1 LYN GRB2 DISC1 ITSN1 PMC6035197__F2 Signaling for apoptosis and carcinogenesis pathway differentiation NR1i1 BAX CASP6 DKFZp781O1323 SMAD2 APC CASP3 SMAD4 IL2 MTOR MYC PMC3655322__F3 Diagram showing some of the upstream elements of the proposed Hippo pathway LATS1 LATS2 AXL CTNNB1 PMC3895871__F1 TWEAK/Fn14 Signaling RELB TRAF5 TRAF1 TRAF3 TRAF2 PMC7108750__F3 Signaling pathways coordinating the hepatic regenerative response EGF HGF EGFR GSK3B PTEN MTOR CTNNB1 LATS1 LATS2 DISP1 SHH SMO NF2 GPR49 CCND1 LGR6 CDC2 APC LRP5 LRP6 IL6 HEL-S-70p ESRP2 RNF43 PTCH1 PMC8483493__F8 Proposed the mechanism within the hypothalamic nuclei proopiomelanocortin (POMC) neurons that leptin signaling may contribute to the high sympathetic nerve activity (SNA) and increased blood pressure observed in the HFD obese rats STAT3 POMC SIRT1 PMC8570864__F5 Unveiling the Mechanism of Principal Drugs of Lianpu Drink on Chronic Gastritis by Network Pharmacology MOG FES FADD PMC5357279__F2 Intracellular trafficking path for SORLA GGA2 GGA1 SNX27 PACS1 PMC7793864__F1 Cartoon summarizes intracellular pathways used by cancer cells to support increased citrate synthesis in mitochondria ACLY HEL-S-133P PHGDH PC PSAT1 PMC3414447__F6 n-Butyl Benzyl Phthalate Promotes Breast Cancer Progression by Inducing Expression of Lymphoid Enhancer Factor 1 GRB10 ABL2 CRIPTO EDNRB A2M APP TCF4 TYK2 CCL17 PMC3412960__F4 Scheme of the Rho signaling canonical pathway identified in Ingenuity Pathway Analysis of the proteins with altered expression in both KO cell lines IGF1R HEL70 EPHA1 LPA HEL-S-47e EZR ARHGDIB ARHGEF11 IGF1 PC ARHGEF2 RTKN RDX PMC8673831__F4 SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes LPL FABP2 TCF2 CDKN2B WFS1 PMC12080399__F11 Mechanistic diagram illustrating the detrimental effects of TRMT10C in the nucleus under hypoxic conditions via m1A modification NLRX1 NLRP3 TRMT10C TAFAZZIN KPNA4 YTHDF2 CPT1A PMC8673831__F3 SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes GSTM1 INSR PTEN MTOR TRIB3 TNF IRS1 PMC7051141__F1 New control of the senescence barrier in breast cancer RELB PAK4 CEBPB PMC7308494__F1 RIPK3 and TGFB1 RIPK3 NLRP3 MLKL TLR4 RIPK1 IL1B PMC4900219__F10 Proposed mechanism of DCLF/cytokine-induced cytotoxic synergy STAT1 TNF PMC4663793__F3 Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway RFWD2 SHISA4 CASP9 ATR SIAH1 PERP CD82 PTEN BBC3 MYC ZMAT3 TSC2 CASP3 CDK2 ATM RPRM PIGS MDM2 APAF1 CCND1 PMC10888664__F2 Evolution of CRC TGFBR2 DCC APC BRAF NRAS SMAD4 KRAS CTNNB1 PMC11338244__F4 Methylation of the PI3K/AKT/mTOR signaling pathway on tamoxifen EZH2 PTEN KRAS PITX2 RHEB ATF3 TSC2 TSC1 ERRFI1 GDF15 ZDHHC22 METTL3 AK4 PMC3516782__F5 Metabolic pathway of mannan in R RAMP2 RAMP1 PMC11338244__F2 Tamoxifen resistance RHEB TSC2 TSC1 PTEN MTOR KRAS PMC1173149__F10 TAp63Alpha-induced apoptosis BAX BCL2 APAF1 PMC5623058__F5 Lipid metabolism regulatory network proposed for the breast of female chickens at hatching, based on significant DEGs and KEGG pathway analysis PPARG LEPR SHH PMC6851151__F1 Current translational potential and underlying molecular mechanisms of necroptosis RIPK3 MLKL PMC5874051__F3 Gene cloning of a neutral ceramidase from the sphingolipid metabolic pathway based on transcriptome analysis of Amorphophallus muelleri ASAH2 CERK GBA2 GLB1 PMC5734045__F2 Interactions between the Wood-Ljungdahl pathway, the Embden-Meyerhof-Parnas glycolytic pathway, and the mevalonic acid pathway for the synthesis of isoprene HEL-S-162eP MVD MVK PMC6046465__F8 The “cross-talk” between purinergic receptors during the uridine triphosphate (UTP)-mediated control of Leishmania amazonensis infection LTB PANX1 PMC5983636__F1 Mammalian target of rapamycin (mTOR) signaling pathway RHEB TSC2 RICTOR TSC1 ULK1 PTEN MTOR DEPTOR PMC4994014__F1 IL-21 signaling pathway CD40 BCR PAX5 JAK3 JAK1 BCL6 PMC4994014__F2 B-cell activation and differentiation CD40 ICOS BTK MHC2TA BCR BCL6 PMC6959353__F1 Example of atom mappings of the 13C-labeling experiment used for isotopomer analysis MAL PC CS CIT PMC4994014__F3 Immunoglobulin (Ig) production CD40 ICOS BTK BCR JAK3 JAK1 BCL6 PMC9258714__F6 SQLE facilitates the pancreatic cancer progression via the lncRNA‐TTN‐AS1/miR‐133b/SQLE axis PCNA SQLE CDK2 CCND1 PMC4994014__F5 B-cell apoptosis STAT3 STAT1 JAK3 JAK1 PMC7431799__F10 Model showing how PRRSV utilizes viral apoptotic mimicry and TIM-induced macropinocytosis as an alternative pathway to infect host cells CDC42 PAK1 CD163 RAC1 PMC10341168__F9 Ginsenoside Rh4 Improves Hepatic Lipid Metabolism and Inflammation in a Model of NAFLD by Targeting the Gut Liver Axis and Modulating the FXR Signaling Pathway TG CYP8B1 FASN PMC9139581__F5 Integrated Analysis of Cancer Tissue and Vitreous Humor from Retinoblastoma Eyes Reveals Unique Tumor-Specific Metabolic and Cellular Pathways in Advanced and Non-Advanced Tumors SLC22A5 SLC25A5 SAG NR1C1 ENO2 HEL-S-133P BAAT SOX3 IL18 HIF1A PFKM HDAC2 PMC7307098__F8 Working model of the innate immune response to papillomavirus infection of the female lower genital tract STAT1 CCR6 CCL20 MYD88 PMC2769196__F4 Acromegaly pathogenesis and treatment GNAS CDK6 HMGA2 GHRH POU1F1 CDK4 PMC5206990__F3 Rationale for combination therapy in lymphoma CD40 CD79B SYK CD79A BTK BCR LYN MTOR JAK1 PMC7471511__F11 Dichotomy in gene regulatory associations during the activated B-cell to plasmablast transition IL-21 CD40 CTCF BATF BCR SPIB IL2 IRF4 XBP1 PMC8065335__F5 Putative mechanisms for CVL218 as a PARP1 inhibitor to combat the COVID-19 disease, derived based on the data present in this study and the known antiviral activities of PARP1 inhibitors previously reported in the literature IL6 TNF PARP1 IL1B PMC6955653__F3 Role of lncRNAs and circRNAs in osteosarcoma CREB3 ROCK1 SRA1 PMC3112285__F2 Pathway Crosstalk RHEB TSC2 TSC1 PTEN GRB2 PMC3117038__F1 The roles of CARM1 and coactivator methylation in DNA damage signaling pathway BAX CARM1 BRCA1 ATM PMC8004207__F17 Schematic diagram showing the effect of prenatal exposure to VPA on the pathological changes in the brains of young-adult male offspring RHEB TSC2 TSC1 PMC9664406__F4 Mitochondrion-targeted RNA therapies as a potential treatment strategy for mitochondrial diseases GRSF1 PMC9755959__F8 MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2 RAB31 SUFU PTCH1 SHH SMO PMC4021516__F7 Wild-type p53 (WT-p53) and mutant p53 differentially regulate Nox4 expression in both TGF-Beta-dependent and independent mechanisms SMAD2 NOX4 TGFBR1 PMC3914472__F1 Metabolic pathway of the glycine cleavage enzyme system and the synthesis of its lipoate cofactor GLDC NFU1 FAS ISCU GCSH LIPT2 LIPT1 LIAS BOLA3 APOH AMT FES HSCB PMC2689134__F4 Pathogenesis of holoprosencephaly BMPR2 FOXH1 SMAD1 DKFZp781O1323 SMAD2 NOG SMAD4 SHH SMO NODAL ACTR1B GAS1 PMC4563671__F8 Death-associated protein kinase 1 promotes growth of p53-mutant cancers TSC2 TSC1 PMC2788597__F3 Metabolic pathway of pitavastatin UGT1A1 UGT1A3 CYP2C9 CYP3A4 UGT2B7 PMC6247470__F3 Paeonol protects against atherogenesis BAX FAS NR1C1 LOX HMGCR CD36 BMP4 MTOR MYD88 PMC8995882__F2 Construction Immune Related Feed-Forward Loop Network Reveals Angiotensin II Receptor Blocker as Potential Neuroprotective Drug for Ischemic Stroke CXCR3 CXCL12 CCL3 CCR5 CCR2 IL2RG CCR3 IL2RA CCL5 CCL2 CXCL8 TGFBR1 TGFBR2 IL1R2 IL1R1 IL13RA1 IL2 ACVRL1 IL17F IL17RC IL10 CCL11 IL13 IL4 IL17A IL10RA IL1A TNF IL17RA IL2RB CXCR1 CCL4L2 CCL4 IL8RB CXCR4 CCL8 IL13RA2 IL10RB PMC6016866__F5 The effect of the IR on the expression of the IGF-1Ec isoform STAT3 IGF1 GHR PMC8678298__F1 Renal and Intestinal Urate Physiology MAL ABCG2 SLC2A9 SLC17A4 SLC22A7 PMC9621223__F2 Short Sleep Duration and Erectile Dysfunction: A Review of the Literature GC NPY ARHA PMC5759178__F6 Schematic model for EGFR-PI3K/AKT signaling activation induced by Notch1C1133Y mutation HDC EGFR NOTCH1 PMC10940489__F7 STAT3 influences cardiac fibrosis through multiple pathways STAT3 SMAD2 SMAD4 PMC8278519__F2 Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities IFNG LOX LIF IL4 PMC4626583__F3 Function of bacterial actin nucleators during infection SHC1 TARP PPIG COMMD1 PMC3425429__F1 Working model depicting some of the multiple signaling pathways that have been reported to modulate cell-cycle activation and/or proliferation in rodent Beta-cells RHEB PRLR TPH1 HGF FOXO1 TPH2 PTEN IRS1 PMC4179136__F5 Perturbation of MAPK signaling pathway at 24 h after MPP+ treatment MAX EGF JUND FAS TGFBI EVI1 BRAF ATF2 MYC FLNA TGFBR1 DUSP3 KEL MAF CHUK ATF4 DUSP14 ECSIT JUN PDGFA DAP3 FOS CRK MOS PDGFRA CASP3 DDIT3 RRAS NLK TRAF2 PMC4179136__F6 Perturbation of ER protein processing pathway at 24 h after MPP+ treatment SVIP CANX DBT CRYAA GANAB PREB VCP PLAA STUB1 HEL-S-99n SEC31A GCS1 BCAP31 DDIT3 DERL2 PMC3935308__F2 High-confidence reaction map of the TSLP signaling pathway TH NFKB2 MYC TEC TSLP BTK NFKBIA FES STAT4 LYN JAK1 CISH SRC GAB2 CRLF2 UNK LCK PMC11394960__F10 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the spleen in Lagovirus europaeus infection NLRP3 TLR4 IRAK1 TRAF6 MYD88 PMC4179136__F4 Perturbation of the MAPK signaling pathway at 9 h after MPP+ treatment MAX DUSP10 EGF FAS LEP SOS1 EGFR EVI1 BRAF MYC FLNA DAO TGFBR1 MAEA NGF NF1 PRKCA CHUK DUSP14 ECSIT JUN CD14 HEL-S-28 FOS CRK MOS CASP3 NLK NFATC3 BDNF RRAS2 PMC8011850__F8 Model depicting the pathway stimulated by TNFA to increase venous endothelial permeability PANX1 SRC TNF PMC3445701__F7 Alzheimer’s Disease pathway from KEGG LPL IDE CASP9 BAD CASP12 GSK3B CASP3 SNCA APP TNF APAF1 FADD PMC4330251__F3 Wnt signaling pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG) (SFRP genes are in red box) BAMBI NR1C1 SOST FIS1 APC SMAD4 SKP1 NLK PMC6480215__F1 Regulation of osteoblast proliferation and differentiation by transcription factors SP7 IHH RUNX2 CTNNB1 PMC6480215__F2 Calvarial bone development and suture closure WNT10B TNC IHH IBSP RUNX2 SPP1 FGFR2 NCAM1 COL1A1 PTHLH PTCH1 WNT1 FGFR3 DLX5 PMC3334867__F5 Inborn Errors of Human JAKs and STATs SOCS1 IFNG STAT3 CNTF STAT1 OSM LIF CLC SOCS3 PMC6848778__F9 KEGG analysis of carbonylated lysosomal proteins in human end-stage PSC POR IDE TEF PMC11974029__F1 Mechanisms through which berberine treats breast cancer involve modulation of the XRCC1 enzyme in BER OGG1 FEN1 PCNA PMC11974029__F2 Mechanisms by which capsaicin treat NSCLC involve modulation of the ERCC1 enzyme in the NER pathway ERCC1 DDB2 DDB1 PCNA TRPV1 XPC PMC2954851__F2 Protein serine/threonine phosphatases in the DNA damage response pathway ATR RAD50 ATRIP RAD1 MRE11A BRCA1 H2AX ATM MDM2 PMC4790586__F5 Signaling cascades through Twist and their roles in carcinogenesis CDH2 STAT3 CD24 FOXC2 PMC11974029__F3 Apigenin holds promise in the treatment of ischemic stroke by modulating RAD51 and BRCA1 during HRR as well as Ku70/80 in NHEJ RAD51 BRCA1 MTOR PMC5740024__F1 pH Dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs GC HEL-S-5 MGMT PMC11974029__F5 Retigeric acid B effectively treats prostate cancer by modulating the MSH2 and MSH6 enzymes involved in MMR MSH6 RAD51 MSH2 BRCA1 ATM PMC5139832__F3 Differentially expressed genes between young and aged tibiae are significantly enriched for ECM-receptor interactions, TCA cycle and cell cycle pathway components CDC2 DBF4 HEL60 CDC6 ORC6 MYT1 CS SDHA DLAT CDK6 SUCLG1 SUCLA2 OGDH E2F4 CDK2 MDH2 CDC25B CDK4 PMC11945191__F1 The host type I interferon signaling pathway by bacteria TBK1 CGAS MAVS TLR9 TRAF3 TRAF6 MYD88 TLR3 TLR4 NOD2 TLR8 NOD1 TLR7 PMC6035044__F2 Prolactin Regulation of the Prostate Gland: A Female Player in a Male Game PRL CCND1 PMC5504267__F2 Reactions involving ROS, antioxidant systems and energy metabolism TXN GCLM GCLC HEL-S-64p NNT HEL-75 PMC3504728__F7 Speculative model of macrophage alternative activation regulation by estrogen SOCS1 JAK1 PMC7670425__F3 Critical roles of FAM134B in ER-phagy and diseases TNFRSF19 PMC6060635__F1 Expanding complement therapeutics for the treatment of paroxysmal nocturnal hemoglobinuria HEL-S-62p C1S C9 PMC4681751__F1 Biological interaction network revealed by Ingenuity Pathway Analysis ZFP36 CCL27 KRT10 TREM1 HTR4 LGALS7B APOE SERPINA1 ZNF365 TNF APOA2 ALB MAFF PLTP C4B_2 DUSP14 PROC HBB LAT2 ITIH4 PMC7826375__F6 The interplay between ATRX and RECQ5 to regulate distinct subpathways of HR PCNA GEN1 BLM PMC8836457__F1 Sclerostin in Bone Diseases LRP5 LRP6 CTNNB1 PMC7957553__F3 ROS-dependent transduction signaling JUN KEAP1 NQO1 PRX FOS PMC2656226__F6 Mitochondrial regulation of the apoptotic pathway is altered in disease and modulated by sirolimus treatment HTRA2 BAD CAD TNF DAO BCL2L2 BTG1 HSPD1 BTG2 FOXO3A MEN1 NFKBIA BOK DIABLO PMC2656226__F9 Complement pathway altered in disease C7 MASP2 CR2 CS C4A C4B_2 CR1 PMC6948348__F4 The integrated NSCLC pathway for compound Liuju formula HPSE HGF TRADD FRS2 EBP CD19 MMP9 VEGFA ME1 BCR COX2 MMP2 GRB2 IL1B PMC5553087__F1 Toll-like receptor (TLR) stimulation, signaling, and immunological outcomes TBK1 TLR1 TIRAP TLR4 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC3860870__F1 Apoptosis by HPV early proteins: A number of the interactions of viral oncoproteins with cellular proteins and their effects on apoptosis FAS TNF FADD PMC8329414__F2 Annexin A3, a Calcium-Dependent Phospholipid-Binding Protein: Implication in Cancer BAX ANXA3 MTOR TNF PMC8581873__F2 Expression and crucial role of long non-coding RNA FGD5-AS1 in human cancers DDX5 WEE1 FGFRL1 PMC3854132__F1 Systems Modeling of Anti-apoptotic Pathways in Prostate Cancer: Psychological Stress Triggers a Synergism Pattern Switch in Drug Combination Therapy VIP EGF BAD EGFR MCL1 PTEN PMC3652637__F11 Neural Regulation of Lacrimal Gland Secretory Processes: Relevance in Dry Eye Diseases EGF GC GRB2 PMC7178030__F1 Timeline of genes involved in gonadal development DHX37 PBX1 DHH CTNNB1 FGFR2 LHX9 WT1 EMX2 FOXL2 NR2F2 SOX9 SRY FGF9 SOX3 ZNRF3 WNT4 AMH GATA4 LEF1 SOX8 PMC6139073__F1 Wingless/integrated (Wnt) signaling pathway FZD2 APC LRP5 LRP6 RHO CTNNB1 PMC8187637__F2 Canonical stress granule assembly pathway EWSR1 HNRNPA2B1 HNRNPA0 EIF2A PMC2724271__F4 Metabolic map of HIF-target genes CYCS ABCF2 BNIP3 CD99 MRPS12 KRT19 BTAF1 CCNG2 NPM1 MMP2 IDE TAOK2 HEL-S-133P HK2 PLAUR MIF VEGFA PGAM1 HEL-S-68p HEL-S-49 ARHGEF1 EN1 ENO1 MRPL4 CXCR4 CP TF SLC25A28 HEL113 ISCU GAS P4HA2 IGFBP2 TERT RARA TFRC NF2 PSMD4 TMEM70 CAD FH PLD2 PDGFA ANXA1 PTGS2 FECH NPAT RBPJ IGF2 NR3C1 HEL-S-130P GYS1 HEL-S-162eP PFKL HEL-S-87p SLC16A10 P4HA1 PMC3196743__F2 The Contribution of Vitamin A to Autocrine Regulation of Fat Depots CEBPA GC KLF5 PMC1421310__F1 High-Throughput Drug Screening of the DPC4 Tumor-Suppressor Pathway in Human Pancreatic Cancer Cells SMAD1 SMAD2 PMC3133232__F8 Schematic model of Nrf2 regulation by Keap1 RBX1 KEAP1 MAF PMC5046039__F2 Molecular regulation of MSCs during bone formation BMPR2 EGF APC CSK IHH SMO PTH DLX5 RUNX2 CTNNB1 PMC2824740__F5 Strain-induced quantitative mRNA-expression analysis of PDL cells related to MAP-kinase signalling and cell cycle, ECM and integrins, and growth factor pathways VEGFC MMP12 COL14A1 VEGFA FOS FGF2 HBEGF EREG CDKN2C FGF9 IL18 BMP2 IL11 PMC3484412__F2 Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway EPO MTOR PMC2990406__F8 A previously unknown miR-290–dependent pathway controls DNA methylation via Rbl2 and affects telomere integrity and telomere-length homeostasis DNMT3B RBL2 PMC7878609__F3 Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling CXCL12 EGF EGFR CXCR4 PMC11621799__F4 Pathway activation in ACO and COPD identified through KEGGpathway enrichmentanalysis TF STAT3 FAS TRADD MLKL IL33 EPO MTOR POR TFRC PIG59 LOX NLRP3 ZBP1 TLR4 USP21 CYLD HEL-S-133P H2AX TNF VHL RBX1 TLR3 HEL-S-162eP HEL-S-87p FADD PMC7397096__F7 Myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice CD40 DDX5 PGR IL4 RUNX2 HDAC3 PELP1 CBL CARM1 NCOR1 FOXO3A TLR4 PC GRB2 BDNF PMC2504032__F8 Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine CDK2 ATF4 CCNA2 EIF2A PMC9388649__F7 TMEM16E affecting bone metabolism through intracellular Ca2+ signal transmission NFATC1 PTH CTNNB1 PMC7660084__F1 Summary of signaling pathways involved in the differentiation of pluripotent cells into corneal epithelial cells TF SMAD1 DKFZp781O1323 RNF43 SMAD2 APC FZD7 SMAD4 ZNRF3 NODAL CTNNB1 PMC548501__F4 Taxotere and Furtulon on cell cycle, apoptosis, and other pathway related gene expression analyzed and visualized by GenMAPP software integrated with cDNA microarray data PCNA TGIF2 BARD1 CDK6 MAP2K6 BRCA1 SRM GADD45B CDK2 BCL2 CDC27 GADD45A CDK9 TEF ELF3 CDK4 PMC8847901__F1 Autophagy and skin wound healing ATG101 ATG10 ATG3 ATG12 FOXO3A ATG14 BNIP3 MTOR ATG5 PMC8929358__F4 Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping WAS PMC3173800__F2 Two major pathways to caspase activation in vertebrates: the death receptor or extrinsic pathway, engaged by the indicated members of the TNF receptor family on the cell surface, and the Bcl-2-regulated mitochondrial or intrinsic pathway BAX TRADD FADD PMC11908393__F8 Tenascin-C induces microglial polarization through the TLR4/MyD88/NFKB pathway TNC TLR4 MYD88 PMC6420571__F6 Beta-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma CDK7 BCL2 MTOR PARP1 PMC3841210__F7 FOLFIRI plus dulanermin (rhApo2L/TRAIL) in a patient with BRAF-mutant metastatic colon cancer BAX FOXO3A DIABLO CTNNB1 FADD RUNX3 PMC5886582__F5 Signature pathway expression of xylose utilization in the genetically engineered industrial yeast Saccharomyces cerevisiae HEL60 ENO2 ACO2 NOM1 HEL-S-4 PCK1 ADH5 ADH7 tal-1 HEL-S-68p PGM3 HEL-S-49 PGM2 FBP1 HEL-S-32 ENO1 MDH2 HEL-S-26 PMC6628492__F4 Synthesis of BDNF and potential downstream involved in the effects of botanicals and active components on depression CRH ARHA MTOR BDNF RAC1 PMC6684519__F7 Hydrogen peroxide inducible clone-5 sustains NADPH oxidase-dependent reactive oxygen species-c-jun N-terminal kinase signaling in hepatocellular carcinoma TRAF4 PMC4790586__F1 Signaling pathways involving the molecules reviewed BMI1 TBX2 JUNB DHFR EZH2 YY1 MDM2 MYC CCND1 TWIST1 CDK4 PMC2375563__F1 Muscle growth: no IGFs, ands, or buts RHEB TSC2 MTOR MYC EIF4E PMC4615578__F9 The mechanisms of the miR-449a tumor suppressive function in neuroblastoma cells TSEN15 MFAP4 CDK6 PKP4 LEF1 PMC5790442__F9 Methylseleninic acid induces NAD(P)H:quinone oxidoreductase-1 expression through activation of NF-E2-related factor 2 in Chang liver cells KEAP1 NQO1 MAF PMC3153880__F3 Schematic representation of the effect of conventional treatment (Conv) and novel treatment (TKIs) on tumor behavior through the EGF-EGFR pathway EGF EGFR PC PMC6162711__F2 NFKB1 p105/p50 regulation of gene expression in cancer HDAC1 IL16 EGFR CXCL1 GADD45B TRAF1 CXCL2 VEGFA CXCL10 S100A9 PMC2176131__F7 Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor–B Signaling EGF EGFR SMAD2 PMC5807852__F7 RHBDD1 promotes metastasis in colorectal cancer RHBDD1 CTNNB1 PMC8080689__F1 Autophagy pathway ATG10 ATG3 ATG12 ATG14 MTOR ATG5 PMC515190__F1 Cholesterol metabolism showing the physiological compartments involved TG ACD ABCA1 PMC5750119__F9 Transcripts corresponding to most genes present in the KEGG Cell Cycle Pathway were increased in abundance in CCDs from rats on Day 2 of development of vasopressin-escape CDK7 MALL SMAD2 MAL MYT1 SKP2 CA14 PMC7102569__F1 Apoptosis signaling in response to infection BAX CGAS MAVS TLR3 IRF3 PMC10380530__F1 Comprehensive Review: Unveiling the Pro-Oncogenic Roles of IL-1ß and PD-1/PD-L1 in NSCLC Development and Targeting Their Pathways for Clinical Management GSDMD IRAK3 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC1763171__F2 The inflammatory, coagulation, and fibrinolytic pathways are linked at many levels, leading to organ failure and eventually death TFPI APC PLG PC CS PMC8772974__F3 Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease UCP2 CGAS TLR4 PMC8591135__F1 Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems TBK1 TRAK1 TIRAP TAB3 TLR9 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR4 TLR8 TLR7 TLR10 PMC5046039__F3 Bone remodeling: (a) in precursor cell stage, the macrophage-colony stimulating factor (M-CSF) binds to its receptor (c-Fms) TEC SYK BTK COL1A1 SPARC IHH BLNK DAP DLX5 TRAF6 RUNX2 MSX2 PMC8264285__F2 Targeting Tumor-Associated Antigen: A Promising CAR-T Therapeutic Strategy for Glioblastoma Treatment EGF CASP9 BAD SP1 GSK3B CR2 PTEN MTOR RHO PPY CTNNB1 FOXO1 BCL2 GRB2 PMC8591135__F3 Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems TLR1 TLR3 TLR4 TLR9 TLR8 IRAK1 IRF3 TLR7 TRAF3 TRAF6 IRAK4 MYD88 PMC5872399__F5 The complexity of AM death Regulation following infection, trauma, and HS HMGB1 TLR4 NOD2 MYD88 PMC8264285__F3 Targeting Tumor-Associated Antigen: A Promising CAR-T Therapeutic Strategy for Glioblastoma Treatment HGF SP1 PAK1 GRB2 RAC1 PMC6136992__F2 Sending mixed signals: Cilia-dependent signaling during development and disease EVC2 GPR161 SUFU SHH SMO INPP5E PMC3469587__F7 SP-A-regulated signaling pathways in human macrophages TLR4 IRAK1 TRAF6 TNF PMC3962840__F5 Relationships between the cellular signal pathways in HAdV-36 infected human muscle cells PTX3 SERINC3 E2F2 CDCA4 ORC6 PKP1 E2F7 DUSP2 PELI1 CENPO MCM10 WDR76 RNF144A CCDC14 MCM5 JARID2 PMC10033690__F1 Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons PTGER2 PTGER3 COX1 PTGIS COX2 TBXA2R PTGES PTGFR PTGIR PMC9503107__F8 Cleistocalyx nervosum var. paniala Berry Promotes Antioxidant Response and Suppresses Glutamate-Induced Cell Death via SIRT1/Nrf2 Survival Pathway in Hippocampal HT22 Neuronal Cells CNP GPX1 SIRT1 PMC3765447__F3 Signaling pathways involving EPCAM, proposed by Maetzel D et al EPCAM APC GSK3B FHL2 CTNNB1 PMC8187207__F9 Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity DAG1 SGMS1 PC SGMS2 PMC3465331__F6 In Vivo Tumorigenesis Was Observed after Injection of In Vitro Expanded Neural Crest Stem Cells Isolated from Adult Bone Marrow MAX NRG1 ATR PCNA PAK1IP1 DHFR SMAD4 ATM MDM2 SUV39H1 PMC9508642__F8 Perindopril sensitizes hepatocellular carcinoma to chemotherapy: A possible role of leptin / Wnt/ Beta-catenin axis with subsequent inhibition of liver cancer stem cells STAT3 APC MMP9 CTNNB1 PMC8873584__F1 SPINKs in Tumors: Potential Therapeutic Targets STAT3 EBP SOX2 PMC8416465__F2 How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension? SLC3A2 PC MTOR PMC7510303__F4 Diseases and regulator effects networks associated with the differentially expressed peptide precursors DUSP10 BSN BIRC6 AGO2 RNF123 PGR STIM1 KALRN KLF14 APC2 THRA GRHL3 COL4A4 SPHK2 JAG2 ATN1 CROCC AHNAK IL17RC KMT2C SCN11A BAHCC1 SYNE2 MMRN1 SYNE1 MUC19 SLC4A4 TSC2 LRP1B SNTB2 MTR PIGR PMC9247709__F9 Schematic diagram illustrating how miR-21/PARP-1 activates the PI3K/AKT signaling pathway to induce EMT and migration of 16HBE cells CDH2 PMC7476571__F4 Viral miRNAs target genes involved in interferon signaling pathway STAT1 IFNGR2 IFNGR1 RIGI STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IRF7 JAK1 PMC11214299__F3 Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia USP25 DYRK2 ULK1 PML LRSAM1 PTEN USP9X MYC TRAF6 SKP2 FBXW7 CBL USP15 SIAH2 GCA USP47 USP6 PMC5971008__F6 Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma LIMS1 RLN2 RSU1 HEL-S-28 LMO1 CPD PMC7238203__F1 DNA sensing mechanisms through the cGAS/STING/TBK1 signaling pathway TBK1 NLRX1 CGAS IRF3 PMC1507568__F3 The p53 response is triggered by many different stresses involving both DNA-damaging and non-DNA-damaging agents MYC CTNNB1 PMC2359939__F9 Proposed mechanism for RES induced apoptosis in LNCaP and PC-3 human prostate tumour cells ELL CCND1 PMC7726415__F1 Major metabolism pathways by Nrf2 HEL107 CD36 GPX4 GCLM HEL-S-10 FASN ME1 FECH HMOX1 FTH1 FTL GCLC HEL-S-26 PMC8393628__F2 Inflammatory Mediators, Macrophages, and Neutrophils in Glioma Maintenance and Progression: Mechanistic Understanding and Potential Therapeutic Applications BAX HGF PSD EGFR UNG PTEN MTOR MYC TRAF6 REL PMC2064670__F5 Model integrating calcium mobilization into the Fas signaling pathway FAS FADD PMC2675492__F1 Biochemical schematics: This figure maybe regarded as the biochemical underpinning of our model TGFA SP1 PMC4282534__F5 Relationship of bm2 to the lignin biosynthetic pathway CAD MTR PMC4385913__F1 Cytotoxic agents impact the Bcl-2 rheostat BAX BAD BMF PMC7730528__F4 Prolidase induces EGFR-downstream signaling pathway HEL-S-162eP EGFR MTOR PMC7943879__F6 Forsythoside A (FTA) attenuates lipopolysaccharide (LPS)-induced endometritis by causing significant changes in the number of miRNAs in bESCs to regulate the target genes involved in different pathway IL-21 CXCL9 TLR4 CXCL5 IL27 IL2RA IL6ST IL6 DHX58 TRAF6 CXCL8 PMC5730419__F2 Alternative signaling pathways of GFLs GRB2 SHE SRC GAS1 RET PMC5832583__F5A Propionyl-CoA carboxylase pcca-1 and pccb-1 gene deletions in Caenorhabditis elegans globally impair mitochondrial energy metabolism FH ACO2 CS MDH2 PMC9323637__F3 Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy HMGCS1 RAB11B HMGCR ARF6 PPARGC1A RHO NOTCH2 PMC3426550__F6 SCS3 and YFT2 Link Transcription of Phospholipid Biosynthetic Genes to ER Stress and the UPR TG PGP PC IRS4 GHB3 MIP PMC7672660__F5 Lipid mass spectrometry imaging and proteomic analysis of severe aortic stenosis TF PTX3 AEBP1 KRT10 CANX CFHR5 C1QB GPX3 ORM2 AHSG IFNG HOXD3 HBB DCN SMARCA4 THBS1 SERPING1 SERPINA7 OSTN CFH HRG FCGR1A APOA2 LAP3 HEL-S-69p C8A C1QC BCL2 PMC7601667__F2 Cross-link between EMT-induced signalling pathways and Autophagy-inducedsignalling pathways EGF TGFA ZEB2 CTNNB1 PMC5646997__F2 Schematic representation of the effects of glutamate excitotoxicity, energy metabolism deficiency and axonopathy in ALS pathogenesis SEMA3A BDNF PMC2771939__F1 Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Signaling in Immune Cell Functions CDC42 LAT RHO PMC2039930__F7 Signal transduction pathways involved in Ha-ras-mediated AEG-1 induction MAX GSK3B MYC PMC4512107__F2 Let-7 targets insulin signaling pathway and thus inhibits cancer cell metabolism RHEB TSC2 EIF4B FAS RICTOR TSC1 HEL-S-133P EBP MTOR MYC EIF4E PMC4479845__F6 Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis CCR5 CCL4 TBP CCL2 PMC9488681__F1 Pulmonary hypertension associated with neurofibromatosis type 1 RHEB TSC2 TSC1 NF1 MTOR PMC11619108__F3 Cnetplot of enriched pathways of DRPs identified through KEGG analysis ZAP70 TAPBP RAF1 ARPC5 PIK3CD ARF6 GSK3B MARCKS HLA-DPB1 PPP3CA IFNG FYN HSPA2 PRKCA PPP2R2C HLA-DQA2 NCK1 VAV3 INPP5D B2M VAV1 ARPC1B CRK ACTR2 ACTR3 PAK1 HSPA4 HLA-A CDC42 HEL-S-103 ARPC4 ARPC2 ARPC3 HLA-DRB1 SPHK1 HEL-S-269 PPP2CA NCK2 HLA-DRA PRKCE HLA-F HLA-DRB4 HEL-S-15 HSP90AB1 CFL2 HEL-S-72p LCP2 HEL-S-89n PPP2R1A ARHA KRAS NFYB PPP2R2D LYN PMC5997832__F1 IRE1A structure and its downstream mechanisms in mild and severe stress RTCB BAX TXNIP BCL2 XBP1 PMC5997832__F2 IRE1A regulates the immune function through various mechanisms including both its kinase (A) and RNase (B) functions IL15 TAPBP MAVS TXNIP GSK3B IL6 RIPK2 NLRP3 IL16 TLR4 IL18 RIPK1 NOD1 TLR7 TRAF2 PMC7542964__F4 KEGG enrichment map of NOD-like receptor signaling pathway MCU DAP ARHA MYC PMC11619108__F2 Cnetplot of enriched pathways of DRPs identified through REACTOME analysis SAP130 OGT BRMS1 PRMT6 RCOR1 SMARCD1 ENY2 KDM6B SMARCE1 RBBP4 CARM1 NCOR1 ARID1B PBRM1 ARID2 SMARCA4 MYST4 SMARCC1 KAT5 MORF4L2 H2AX CHD4 TAF12 PAK1 KDM2A CALM1 CDC42 RHO WDR5 TRRAP GATAD2A YEATS4 SMARCC2 HCFC1 MYH9 TBL1XR1 MYL6 MTA2 DPY30 TBL1X SGF29 SUPT20H IKBKAP H2AZ2 COPRS CHD3 NCOR2 HDAC1 SAP30 KDM1A SMARCD2 SETD1A KDM5C MBD3 PMC7913190__F2 Caspase-11 upregulation occurs as a result of PAMP and/or cytokine signaling and can be amplified by complement signaling TBK1 HEL-S-62p STAT2 IRF9 MAL IRAK1 IRF3 IRF7 TNF TRAF6 IRAK4 MYD88 IFNG STAT1 NLRP3 IFNAR2 CPB1 JAK1 TYK2 PMC6153124__F1 Various published mechanisms of resistance to FMS-like tyrosine kinase 3 inhibitors FLT3 PGP RAD51 PMC7407660__F2 COP9 signalosome (CSN) partners with ubiquitin-specific protease 15 (USP15) and 48 (USP48) in the NFKB signaling pathway SOCS1 RBX1 USP15 SKP1 USP48 PMC11050207__F4 Significantly altered KEGG pathways in LAPST versus CPG group comparison MAX SYK BAD FAS TRADD RBL2 PTEN MTOR TNF SKI FLNA RAC1 MEF2C EIF4E MYD88 RHEB MPL TSC2 BRCA1 MEI1 GRB2 TRAF2 PMC11050207__F5 Significantly altered KEGG pathways in LAPST vs VWF BAD VASP FYN CD36 RHOD DMP1 PTEN CHAD SHE NPAT PMC4628383__F1 Schematic representation of the brain microvasculature features and corresponding Impact of TS VCAM1 PECAM1 PMC7541012__F2 Roles of cancer‐associated fibroblasts (CAFs) in cancer chemoresistance CHI3L1 STAT3 IL10 HGF IGF1 LIF BCL2 LRP6 IL6 IRAK4 PMC9117765__F2 TEAD4 as an Oncogene and a Mitochondrial Modulator LATS1 LATS2 RHO NF2 MTOR TEAD4 CTNNB1 RUNX3 PMC9117765__F3 TEAD4 as an Oncogene and a Mitochondrial Modulator LATS1 LATS2 TCF4 NF2 MTOR VGLL4 TEAD4 CTNNB1 RUNX3 PMC9168599__F8 Activation of PI3K/p110A in the Lung Mesenchyme Affects Branching Morphogenesis and Club Cell Differentiation ISL1 SOX9 PTEN FGF10 HES1 PMC8607377__F2 Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia STAT3 ZEB2 PMC6448148__F1 Biosynthesis of all known wyosine bases TYW5 TYW3 TYW1 PMC11718879__F1 Hedgehog signaling pathway PTCH1 SHH SMO PMC9632491__F1 Protein phosphorylation in cell signaling, disease, and the intervention therapy TSC2 COMP BAD RHOD PTEN RAC1 PMC9632491__F3 Protein phosphorylation in cell signaling, disease, and the intervention therapy MAX ATR TRADD BRCA1 BCL2 MTOR MYC PAX6 TNF TRAF2 PMC3922035__F5 Protein interaction network analysis of the up-regulated proteins in M CALU PNP HEL113 FLNB CTSO CLU MPC2 PMC4131037__F5 ChiBE overview IFNG SUMO1 STAT1 PIAS1 PMC9632491__F8 Protein phosphorylation in cell signaling, disease, and the intervention therapy KIF7 ITGB8 H2AX NLK MYC CTNNB1 PMC3535741__F1 PI3K/AKT/GSK3/mTOR signaling TSC2 TSC1 PTEN MTOR CTNNB1 PMC9632491__F4 Protein phosphorylation in cell signaling, disease, and the intervention therapy CDK6 PCNA E2F4 MCL1 CFTR MYC ERH CDK4 CTNNB1 PMC9632491__F5 Protein phosphorylation in cell signaling, disease, and the intervention therapy EGF TRADD PAK1 EGFR GRB2 TNF TRAF2 PMC9632491__F6 Protein phosphorylation in cell signaling, disease, and the intervention therapy FLT3 SYK EGF ENG RASSF1 IRF9 EGFR LYN GRB2 SRC UNK IRS1 PMC4712335__F8 Age-related neuroinflammation and changes in AKT-GSK-3B and WNT/ Beta-CATENIN signaling in rat hippocampus GSK3B DVL2 AXIN2 CTNNB1 PMC9632491__F7 Protein phosphorylation in cell signaling, disease, and the intervention therapy TGFA TIRAP MLKL HEL70 MYD88 PMC6468845__F3 Reprogramming of lipid metabolism under hypoxia SIAH2 NEU3 FASN FABP4 ADFP CPT1A PMC7359022__F2 Release of HMGB1 protein and HMGB1 signaling pathways HMGB1 TLR4 TLR9 CXCR4 MYD88 PMC4161359__F1 Mechanisms of AR pathway activation in CRPC PMC4161359__F2 Feedback pathways of AR, PTEN, and PI3K FKBP5 JUN EGR1 EZH2 MTOR PMC3789182__F7 Schematic illustrating a model of NA anticancer activity is proposed EGF TSC2 TSC1 HK2 IL6 TNF PMC7359022__F4 Dual role of HMGB1 in chemoresistance HMGB1 PINK1 TLR4 MTOR SIRT6 MYD88 PMC8269070__F4 Dexamethasone for Severe COVID-19: How Does It Work at Cellular and Molecular Levels? TF STAT1 STAT2 GRIP1 IRF3 PMC3860334__F7 Different vesicle transport pathways and the functions of Rab GTPases identified from the hUCBMSC MVs RAB15 RAB14 RAB31 RAB34 RAB32 RAB37 RAB18 RAB35 PMC5761799__F8 Metabolic map of phenolic and glucosinolate metabolism in the primary inflorescence stems of the wild type, ccr1-6, and ccr1-6 ProSNBE:CCR1 lines CAD ACD PMC3431883__F3 Signaling mechanisms of oligodendrocyte injury STAT1 FAS FADD PMC7523401__F8 Target-Pathway network for HQ-BS anti-IBD STAT3 PPARG TGFB1 EGFR MTOR CCL2 CXCL8 HMOX1 IFNG STAT1 INSR TLR4 IL18 PRKCA CCND1 IL1B CASP9 IL10 JUN SELE IL13 IL17A PTGS2 MMP9 VEGFA IL6 TNF CXCL10 FOS IGF1 RELA CASP3 VCAM1 PMC5896143__F1 Violacein biosynthetic pathway (a) and plasmid maps of the complete (b) and partial (c, d and e) operons for violacein biosynthesis TG BAD MAL NOA1 NDE1 ME1 PMC7523401__F7 Distribution of partial targets of HQ-BS on the IBD pathway IL-21 IL10 APC IL2 IL23R PMC6056925__F5 B cell receptor signaling pathway and network of anti-inflammation HEL-S-72p CD79B CD79A RRAD VAV2 CCR5 INPP5D CD22 PTPN11 CD19 MMP9 PTPN6 HRAS BTK PLCG1 SOST CDK5 BCL10 BCR AK1 LYN MAP2K1 SRC YWHAG PMC5576859__F7 Distinct Functions of Argonaute Slicer in siRNA Maturation and Heterochromatin Formation AGO1 CHP1 ARC PMC9539803__F1 Frontline workers: Mediators of mucosal immunity in community acquired pneumonia and COVID-19 TMPRSS2 EGF CXCL1 IL33 CXCL2 IL6 CXCL10 CCL2 CXCL8 TREM2 CCL7 JAK1 ACE2 IL1B PMC3077220__F1 Hepatitis C Virus NS2 Protein Triggers Endoplasmic Reticulum Stress and Suppresses its Own Viral Replication EIF2A XBP1 PMC7962658__F6 Effects of Cryptotanshinone (Cts) on the Akt-GSK-3Beta-mPTP signaling pathway GSK3B CASP3 PMC7030939__F7 Changes in the proteome of sea urchin Paracentrotus lividus coelomocytes in response to LPS injection into the body cavity EHD2 AMPH VPS35 VPS25 CAPZB F3 LDLR PML ARHA OTP PMC7030939__F8 Changes in the proteome of sea urchin Paracentrotus lividus coelomocytes in response to LPS injection into the body cavity HEL-S-99n RILP CD36 TLR4 VAMP3 CD14 TUBB M6PR SRA1 MPO PMC8699276__F1 Targeting KRAS in NSCLC: Old Failures and New Options for “Non-G12c” Patients RLBP1 LOX TIAM1 PAK1 PTEN GRB2 MTOR RAC1 PMC5872597__F5 Celtis choseniana eethanol extract-mediated anti-inflammatory activity TLR3 COX2 IL16 TLR4 IL6 SRC IL1B MYD88 PMC6050907__F4 Neurotrophic signaling cascades CRK EGF NGF GDNF PDGFRA ARHA GRB2 MTOR BDNF RAC1 PMC5988709__F1 NNMT links NAD+ and methionine metabolism NNMT HEL-S-182mP HEL-S-20 PEMT NAMPT HEL-S-61p PMC8351122__F2 Fibroblast Growth Factor 19 in Hepatocellular Carcinoma STAT3 SHC1 FRS2 EGFR PDLIM2 SMAD2 NGFR PTPN1 PTPN11 EIF4E DIRAS3 FGF8A CRK TSC2 THRSP FGFR4 NTRK1 RIT1 GRB2 SHC3 UBB PMC4694848__F7 Thioredoxin 1 mediates TGF-Beta-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma CDH2 TXN GSK3B PMC4116528__F9 Snail regulates Nanog status during the epithelial–mesenchymal transition via the Smad1/Akt/GSK3B signaling pathway in non-small-cell lung cancer SMAD1 GSK3B PMC5341249__F2 Assays for the identification of G protein signalling pathways using the constitutive activity of an orphan GPCR FAR1 ARHA PMC3432651__F2 Involvement of the target of rapamycin (mTOR) pathway in human disease syndromes RHEB NF1 PTEN NF2 VHL PMC6954967__F8 Genes within the cGMP-PKG-Ca2+ signaling pathway altered via alternative splicing in the myocardium of DM and ChD mice CACNA1C HDAC7 ARHGEF10 MEF2D PMC7611834__F3 T regulatory cells as a potential therapeutic target in psychosis? Current challenges and future perspectives TGFBR2 STAT3 RORC SMAD2 SMAD4 FOXP3 PMC8204251__F1 Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy? MLKL IFNAR1 MTOR IL6R PMC6406365__F1 A simplified model for canonical HhP SUFU PTCH1 SMO PMC9691967__F3 Tailoring biomaterials and applications targeting tumor-associated macrophages in cancers CD40 NPS MHC2TA BCR F3 MARCO PMC12100877__F2 Emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome NLRP3 GC WTAP IL1B GATA3 PMC4669099__F3 Targeting BCR signaling attenuates homing, survival, EMDR and MRD of malignant B cells CD79B SYK CD79A BTK BCR BLNK LYN PMC9396390__F2 Targeting tumor microenvironment for cholangiocarcinoma: Opportunities for precision medicine CXCL9 CCL2 PMC2927952__F3 Insulin signaling pathway from PathVisio FASN PRKCZ ACACA INS PRKAA1 IRS1 PCK2 ACACB PRKCI INSR PFKP PRKAA2 PRKAG1 FBP1 PMC5659938__F11 MiR-21-mediated suppression of Smad7 induces TGFB1 and can be inhibited by activation of Nrf2 in alcohol-treated lung fibroblasts STAT3 TGFB1 PMC10419760__F1 TLR2 MyD88-dependent signaling pathway TIRAP TAB3 IRAK1 TRAF6 IRAK4 MYD88 PMC5662125__F1 Bile acid receptors link nutrient sensing to metabolic regulation CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC7488343__F7 Obesity, ER stress, miRNAs and endothelial function ATF4 XBP1 PMC2862089__F1 Signal transduction pathways and crosstalk activated by insulin/IGF-1 receptor and GPCR systems RHEB TSC2 RICTOR TSC1 RIN1 MTOR IRS1 PMC8904950__F5 Knockdown of TRIM44 inhibits the progression of ovarian cancer and is related to the FOXM1-EZH2 signaling pathway CYP24A1 DDR1 MYBL2 TCF4 HUWE1 TRIM44 FOXM1 BIRC5 PLCG1 TXLNA SP100 DMD AHNAK TRIB3 KIF11 ID2 E2F8 PDGFA RRM2 EZH2 NOTCH2 ACOT11 USP14 CBL MCM3 CENPA RPS6KA3 DACH1 CENPB PMC10609929__F2 Modeled DDIs for phenytoin CYP2C19 CYP2C9 CYP3A4 PMC4749929__F2 Pumping the breaks on B cell development SPIC SYK BLNK ATM IRF4 PMC7019526__F1 Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase receptor type B (BDNF/TrkB) signaling supports neuronal survival, plasticity, differentiation, and growth via activation of several functional downstream cascades PLCG1 PMC8599992__F9 Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability ERCC1 BLM SLX4 EME1 RMI1 SLX4IP PMC8599992__F7 Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability ERCC1 FANCD2 NEIL3 FANCM SLX4 PMC3566011__F8 HDAC6 Deacetylase Activity Is Required for Hypoxia-Induced Invadopodia Formation and Cell Invasion EGFR FURIN HDAC6 PMC6413705__F1 Complement dysregulation in complement-mediated HUS Complement activation initiated by any of the three pathways (classical, alternative, or lectin pathway) leads to C3 activation and C3 convertase formation on C3-opsonized surfaces FH HEL-S-62p THBD VTN DGKE PMC4706579__F3 IL-23/T17 pathogenic axis is an important therapeutic target in psoriasis STAT3 NFKBIA REL IL23R PMC7200161__F6 Schematic model for possible signaling pathway related to the role of ALK7 in mediating BAT responses to nutrient stress KLF15 SMAD2 PMC7558805__F6 Sphingolipid biosynthetic pathways: ORM1 GHB3 ORM2 PMC12022663__F8 Regenerative mechanisms induced by HAps encapsulated in hybrid hydrogels S100A4 MYH9 FGF2 PMC9313589__F1 Pharmacological targets for the induction of ferroptosis: Focus on Neuroblastoma and Glioblastoma RIPK3 BAX MLKL GPX4 PMC7024062__F1 CS response HEL-S-62p C2 C4B_2 PMC3866163__F11 Global Assessment of Antrodia cinnamomea-Induced MicroRNA Alterations in Hepatocarcinoma Cells SYK BTK BCL10 BCR CD72 RASGRP3 GC CD22 BLNK CD19 LYN GRB2 PMC9313589__F2 Pharmacological targets for the induction of ferroptosis: Focus on Neuroblastoma and Glioblastoma RIPK3 BAX MLKL GPX4 PMC7308516__F2 Microbiota in cerebrovascular disease: A key player and future therapeutic target TSLP TLR4 APC MSC SIGIRR IRAK1 TRAF6 IRAK4 MYD88 PMC9687595__F2 Wound Healing versus Metastasis: Role of Oxidative Stress KEAP1 NQO1 TNF NOX4 IL1B PMC4128061__F2 Activation and regulation of BMP/Smad-dependent signalling BAMBI SMURF1 SMAD6 SMURF2 PMC4490281__F1 Simplified schema demonstrating proposed mGluR–eEF2–AMPAR pathway: Postsynaptic binding of glutamate leads to activation of ionotropic (AMPAR, NMDAR shown) and metabatropic (mGlu1/5 shown) glutamate receptors EEF2K EEF2 ARC MTOR EIF4E PMC8764638__F1 Reviewing clinical considerations and guideline recommendations of C1 inhibitor prophylaxis for hereditary angioedema C6 C7 HEL-S-62p C9 PLG PMC6954967__F3 Genes of the cGMP-PKG-Ca2+ signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2 PDE2A PLCB4 CACNA1C MEF2D PMC7379131__F3 Inflammatory Tumor Microenvironment of GBM and its Therapeutic Implications CXCL12 EGF CCL22 MIF FOXP3 CCL2 PMC9361616__F8 IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis HGF FOXO3A IFITM3 PMC3188430__F7 miR-486 is an important regulator of PTEN/AKT signaling in normal and dystrophic muscle PIK3R1 PTEN PMC7738626__F2 IFN-I response and signaling pathways in malaria parasite infections CD40 TBK1 CGAS MAVS AK3 IFIH1 TLR9 TRAF3 TRAF6 MYD88 HAVCR2 HELZ2 STAT1 RTP4 TLR4 STAT2 PARP14 IRF9 HELB IRF3 TLR1 RIGI INPP4A IFNAR2 FOSL1 IFNAR1 TYK2 PMC8467939__F4 Can the Mitochondrial Metabolic Theory Explain Better the Origin and Management of Cancer than Can the Somatic Mutation Theory? OXCT1 GOT2 HEL-S-133P PMC7873978__F1 Lipoic acid metabolism pathways in E LIPA OGDH LIPM PMC6349487__F3 TLR2, TLR3 and TLR9 regulate a robust immune response following HSV-1 infection TBK1 TLR3 TIRAP TLR9 IRF3 TRAF6 MYD88 PMC8055972__F8 Regulation of VM formation and NPC metastasis by the miR-124/Foxq1 axis FOXQ1 EGFR MMP2 MMP9 PMC6519375__F7 CLIP‐170 controlling Met RTK recycling in migrating cells HGF PMC9324963__F2 IL‐22 in homeostasis and diseases of the skin STAT3 STAT1 MTOR JAK1 TYK2 PMC6710175__F3 Hepatocellular carcinoma development in the Mat1a knockout mouse CYP2E1 BCL2 PMC7574311__F3 Leaf-specific DEG attributed to photosynthesis are enhanced in SPL13RNAi plants ASS1 PC NDP PMC2442829__F1 Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations RHEB TSC2 PI3 PTEN MTOR PMC4246083__F8 NLRP3 regulation by GPSM3 TPR NLRP3 IL16 IL1B PMC2442829__F2 Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations EGFR MDM2 MTOR PMC4515859__F3 Biochemical network of arachidonic acid metabolism GPX6 PLA2G10 COX2 CPA3 ALOX12B PTGES3 PTGS1 ALOX12 EPHX2 ALOX15B PMC4833611__F1 Nurr1 pathway and Nurr1‐based therapies for Parkinson's disease GDNF SP1 HEL-S-66 RET CTNNB1 PMC7970560__F11 Modulating the PI3K-Akt signaling pathway and MAPK signaling pathway of ginseng against ALI/ARDS MAX SYK JUND BAD TRADD CD19 TNF TRAF6 RAC1 MEF2C MYD88 BCR TLR4 NLK MDM2 GRB2 TRAF2 CCND1 PMC6465620__F1 M6A function in AML PRMT1 MYB SP1 RBM15 VIRMA SP2 PTEN MYC EIF3S3 WTAP CEBPZ METTL14 BCL2 METTL3 PMC8086041__F1 Pulmonary Macrophage Cell Death in Lung Health and Disease CASP9 GSDMD CASP8 ZBP1 MLKL IL33 CASP3 DFNA5 IL1A PMC2915669__F6 Model showing the interorganellar flow of acetyl units in C TES HEL60 PDC CIT PMC5811325__F2 Ras signaling pathways MLST8 RICTOR MTOR PMC3598331__F4 Hindlimb transcriptional regulatory pathway genes suggested to be important in talipes equinovarus pathogenesis RIPPLY2 PITX1 TBX4 PMC6830055__F1 Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance OGT SIRT1 PMC3524227__F1 Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells BAX MCL1 PMC6889404__F1 hnRNPA2B1, an RNA-binding protein, can function as an m6A reader and is involved in RNA transport, processing or splicing JMJD6 TBK1 CGAS HNRNPA2B1 IFI16 IRF3 PMC3680752__F10 A: the top-associated network as defined by Ingenuity Pathway Analysis (IPA) for NAc mRNAs upregulated in HVRs vs PARP12 ARL2 ARHGAP18 TCEA2 PMC11855299__F6 SMG modulates OBD by regulating the activity of both transcriptional and metabolic pathways BMP2 CPT1A SIRT1 PMC4514105__F1 Cell death FAS FADD PMC6222792__F5 Pathway networks related to estrogen receptor alpha KLRC2 HHIP DDIT4 F2RL3 CTH FADS2 MTOR CS CSF3 FOS ID3 HEL114 RAB3B CHST4 LY96 CXXC4 INHBA INHBE PHGDH ID4 DHCR7 ASNS FDFT1 SESN2 PMC4562806__F1 New immunotherapies targeting the PD-1 pathway BATF APC PTEN MTOR PMC4562806__F2 New immunotherapies targeting the PD-1 pathway STAT3 EGFR STAT4 PTEN NFATC1 VEGFA PMC6364001__F8 Proposed model of intracellular pathways engaged within, and functions of, HSV-specific CD8+ T cells from protected ASYMP individuals STAT3 STAT1 IL2RB STAT2 GZMK IFNAR2 IFNAR1 IL2RA IL6ST JAK1 TYK2 IL6R PMC2955764__F1 Sonic hedgehog signaling pathway HHIP SUFU SHH SMO PMC5821903__F1 Schematic overview of anabolic and catabolic signaling in skeletal muscle IGF1 MYOT SMAD2 IGF1R MTOR GHR PMC10675221__F2 Results of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis STAT3 SYK PIK3CA CCR5 MCL1 JAK3 GSK3B HIF1A MAPK9 CCNA2 RXRG MAPK3 HDAC3 MAPK14 STAT1 BCL2L1 FYN ALOX5 NLRP3 PDPK1 PRKCA MMP2 MMP3 ITK FLT1 KDR MDM2 SRC HDAC2 NOS2 ROCK2 ITGB3 TNF HMGCR RXRA EDNRA CDK2 BCL2 MAPK10 CDC25B MAPK11 PGR EGFR FABP1 HLA-DRB1 BRAF IGF1R PPP2CA MTOR MAP3K14 ITGAV BTK PLCG1 RIPK2 INSR F2 NR3A2 TLR4 CNR1 IL2 CCNB1 RXRB CDK4 CDC2 JUN CYP17A1 ITGA4 NGFR PTPN1 PTPN11 FABP4 MMP9 PTGS2 IL6 PTPN6 PARP1 HDAC1 RORC RPS6KB1 RELA CASP3 CHEK1 NTRK1 CFTR ERBB2 JAK1 CPT1A LCK PMC10675221__F3 Direct targets of the ethyl acetate extract from decoction of Sargentodoxa cuneata (EAdSc) action on the NOD-like receptor signaling pathway SLA TANK MCU IL2 PMC7884719__F1 BDNF and MAP kinase pathways in combined portrait of depression TXNIP GSK3B EFNA1 NUMA1 KRT19 ANGPT1 ERRFI1 ITGA2 PRKCA IER2 SPRY1 P2RX7 TRIB2 DNAJB1 FOSB FLNB HOMER1 RBMS1 JUNB APC DUSP4 VEGFA ATF3 SPRED1 IGF1 BTG2 DOCK4 EGR2 BDNF KLF4 RGS2 FGF12 HPCAL1 GEM ARC DUSP2 PHKB PXDN NF2 RPS6 SPRY4 KLF6 SPRY2 ZMYND11 LMO4 KCNK1 IGFBP5 HEL-S-102 BMP2 RGS4 DKFZp686P11128 GAB2 PMC7049344__F7 Proposed signaling pathway downstream of CD36 through which oxidized low-density lipoproteins (oxLDL) activate phosphodiesterase 3A (PDE3A) to suppress cyclic adenosine monophosphate (cAMP) signaling SYK CD36 PDE3A PMC7585656__F1 Reactive oxygen species- (ROS-) mediated inhibition of glycolysis reroutes flux into the oxidative arm of the pentose phosphate pathway HEL-S-162eP HEL-75 PMC6301827__F7 Schematic representation of the relationship between Rab1a and the HIF-1a/miR-212-3p/Rab1a regulatory pathway in HCC proliferation and migration RAB1A CDK2 HIF1A CDK4 PMC5993211__F1 Innate Antiviral Immunity in the Skin TBK1 MAVS STAT2 IRF9 IFIT1 IFIT3 IFIT2 IRF1 IRF3 IRF7 TRAF3 STAT1 ISG15 OAS1 OAS2 PMC2872883__F2 TIF scores for genes in the KEGG colorectal cancer pathway MAPK1 PIK3CA JUN BAD PIK3R5 PIK3CD AKT3 BRAF PIK3R1 TCF7L1 RHO MAPK8 MYC KRAS FOS RAC1 SET MAPK3 BIRC5 TCF7L2 APP MAP2K1 LEF1 CCND1 PMC6920888__F8 The anti-melanogenic mechanism of PS and PTS MC1R PTS PMC2872883__F3 Small cell lung cancer PIK3CA AKT3 PTGS2 TRAF3 TRAF6 BCL2L1 NFKB1 RELA IKBKB TRAF1 BIRC2 CCND1 BIRC3 PMC3994550__F1 Insulin signaling pathway FOXO1 PDK2 MTOR IRS1 EIF4E PMC3906328__F1 IL-17 signaling and A20 ITCH RNF11 ANAPC5 NOD2 TRAF6 IL1B PMC7331943__F3 Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression ACTN1 PDK4 HEL-S-62p CD36 C2 AURKB PC PMC5777758__F5 Tumor exome sequencing and copy number alterations reveal potential predictors of intrinsic resistance to multi-targeted tyrosine kinase inhibitors CDC2 CDKN2A CDK6 CDK2 CDKN2B CDK4 PMC9218738__F1 The NLRP3 Inflammasome in Mediating Glomerular and Tubular Injury in Diabetic Nephropathy GSDMD NLRP3 IL16 TLR4 RIPK1 HEL-S-11 FADD PMC5686346__F8 Proposed model of miR-130a mediated dysregulation of mTOR pathway in HGSOC TSC2 TSC1 MTOR PMC3023470__F9 Schematic illustration of the sphingolipid metabolic pathway in CHO cells expressing SPHK1/2 and hSPNS2 SPNS2 SPHK2 SPHK1 PMC7563696__F3 Rho GTPases in spine morphogenesis CDC42 PAK1 LIMK1 ARHA RAC1 PMC3517549__F5 Evolution and Origin of Animal Toll-Like Receptor Signaling Pathway Revealed by Network-Level Molecular Evolutionary Analyses MAP3K7IP1 SARM1 MAL IRAK1 TAP1 TRAF6 IRAK4 MYD88 PMC5657420__F1 Classical pRb pathway demonstrates the utility of CDK inhibitors, such as palbociclib, in RB+/+ osteosarcoma CDK6 CDK2 CDK4 PMC2955136__F3 Highly expressed proteins in MII oocytes MAX TH CHD4 SAP30 NONO RELA POLD2 SATB1 PMC3677579__F2 Accessory molecules for Toll-like receptors and their function TLR1 UNC93B1 TLR3 TLR4 TLR9 TLR7 PMC2955136__F4 Highly expressed proteins in zygotes APOE TRIM17 B2M CS EPN2 ALB ABAT IFNG RPN2 UBE2B UBE2D2 DBI RPN1 UBE2E1 HEL-S-32 AGL MDH2 C4B_2 PMC7237728__F7 Effect of DFX on Mtb-infected macrophages HEL-S-162eP HIF1A PMC7924562__F1 Momelotinib and CFM4.16 synergistic combination CDC2 STAT3 CDC20 PMC5731741__F4 FGMD: A novel approach for functional gene module detection in cancer SNX20 hIAN7 FMNL1 SLA CMKLR1 CCR5 CD180 MYO1F MYO1G TAGAP IL16 TMEM150B DOK3 LILRB1 TFEC CCRL2 ITGB7 TNFRSF9 PRDM1 MPEG1 CLEC4E MNDA NLRC4 GPR84 SLC9A9 LHFPL2 FGL2 ADAP2 BIN2 IFFO1 HCLS1 PIK3R5 LYZ NCF1 TNFRSF18 CSF2RB CD37 TLR4 GPRIN3 TLR8 TLR7 TYMP SIGLEC1 DOCK8 IKZF1 ITGA4 SIRPB1 PTPN22 TLR1 SIRPB2 RCSD1 GIMAP8 APBB1IP LILRB2 IMAP1 WDFY4 LILRB4 GAL3ST4 GAB3 MS4A6A TMEM106A NPL CD300LF IGSF6 SLC37A2 CD68 IAN4L1 PMC6528487__F1 Selected genomic alterations are indicated by an asterisk (*): fibroblast growth factor receptor (FGFR) pathway (FGF19, FGF4, FGF23, FGF3, and FGF6 amplifications) FGF8A FGF7A FRS2 FGF7B FGF5C GRB2 MTOR FGF23 PMC3517549__F1 The Evolution and Origin of Animal Toll-Like Receptor Signaling Pathway Revealed by Network-Level Molecular Evolutionary Analyses TBK1 TIRAP TLR9 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 TLR7 PMC5731741__F3 FGMD: A novel approach for functional gene module detection in cancer CD3D LY9 FMNL1 TMEM140 AKNA APOBEC3C PARVG FAM78A FGD2 TNLG7A KLHL6 CCR2 KBTBD8 CD5 CD180 CTSS MYO1G KCNA3 TAGAP ITK SIT1 TRAF3IP3 CCR1 CD6 CXCR6 GZMK PIK3AP1 RUNX3 SPN PLCB2 VCAM1 IL12RB1 BIN2 PARP15 VNN2 SLAMF7 POU2F2 EPSTI1 PYHIN1 CD2 MAP4K1 ARHGAP30 SIRPG RCSD1 UBASH3A BTLA LYN CD3E LCK PMC11762942__F3 Amino acid metabolism in chondrocytes SOX9 PMC8445033__F1 Convergent Loss of the Necroptosis Pathway in Disparate Mammalian Lineages Shapes Viruses Countermeasures RIPK3 ZBP1 MLKL RIPK1 PMC4133236__F12 CXCL12 Induces Connective Tissue Growth Factor Expression in Human Lung Fibroblasts through the Rac1/ERK, JNK, and AP-1 Pathways CXCL12 CXCR4 RAC1 PMC5988105__F1 Currently approved and available IBD therapies include: four anti-TNF agents, namely infliximab, adalimumab, certolizumab pegol, and golimumab, and two anti-integrin agents, natalizumab and vedolizumab MADCAM1 TNF PMC12003104__F2 Relationship between iron metabolism disorder and diabetes and its complications ATOX1 CCS ATP7B ATP7A CP PMC5652951__F8 Schematic diagram of the role of IL-33 in the regulation of the biological behavior of glioma cells IL33 MMP2 MMP9 PMC8616288__F2 FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance STAT3 TSC1 BCL2A1 GSK3B BCL2 CCND1 TYK2 PMC8616288__F3 FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance CDH2 BAX BAD HGF MDM2 MTOR PMC5988105__F2 SMAD pathway SMAD2 SMAD4 PMC5101236__F1 Schematic signaling pathways elicited by VEGF JUN SOS1 NRP1 KDR MTOR MYC FOS PMC11762942__F4 Relationship between lipid metabolism and OA pathogenesis CH25H HIF1A CYP7B1 NOX4 PMC6879798__F1 InterferonB signaling pathway regulated by RLRs MAVS TRIM25 TANK TRAF3 PMC526469__F6 Working model for SPRR1A activation in the myocardium STAT3 SPRR1A LIF IL6 PMC9583737__F7 Wnt-mediated fibrosis in CD SMAD2 APC PMC6165231__F1 Hedgehog (Hh) pathway activation SUFU EGFR SHH SMO PMC4221415__F5 Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics KRT20 AURKA SYK KRT10 PARVB PARVG HEL-S-53e HEL111 MERP1 LIMS3 DDR2 MAPK9 STK33 IRAK4 PRKAA1 MAPK14 MAP3K2 TEC NME4 WEE1 HEL-S-1 AHNAK LIMS1 HINT1 LIMK2 CSNK1D LIMK1 RPS6KA4 MIF EPHA1 TBR1 PAICS EPHB3 NAPSA BMP2K MAP3K1 FER ADK PRKAG1 CSK PRKAB2 PRKAB1 DEFA1B NQO2 TIMP1 PTK6 ABL2 EGFR MLKL IKBKE THRAP3 TANK BRAF TNS1 AZI2 STRADA LATS1 ALDH2 DERL1 MCCC2 IRAK3 AIMP2 NENF CHEK2 TTN EIF5B HEL2 YWHAG HSP90AB1 KRT2 YES1 LRRK2 KPRP FRK HRNR KRT3 KIT PC4 FECH KRAS RIPK3 CAMK2D PRKAA2 VAT1 ALDH1A2 MAP2K1 CDC37 CAMK2G YWHAZ PMC9000186__F7 Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury SPHK2 SPHK1 TNF PMC9000186__F8 Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury SPHK2 SPHK1 TNF IL1B PMC5835698__F2 Antitumor mechanisms of ivermectin HMGB1 IRF9 IFIT1 APC SOX2 IFIT2 ASCC2 MTOR FILIP1L AXIN2 CTNNB1 ISG20 CD44 CD24 PAK1 OASL ATG5 GPR49 PMC9000186__F1 Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury CERK SPHK2 SPHK1 PMC9504455__F2 Crosstalk between Glycogen-Selective Autophagy, Autophagy and Apoptosis as a Road towards Modifier Gene Discovery and New Therapeutic Strategies for Glycogen Storage Diseases GAA BAX TSC2 TSC1 ULK1 TFEB PMC7918477__F1 ER stress and unfolded protein response (UPR) signaling pathway ATF4 EIF2A XBP1 PMC3110678__F3 SAT and PT domains of NSAS in aflatoxin B1biosynthetic pathway HEXB HEXA CLC PMC3068163__F1 Melanoma Molecular Disease Model BAX BAD CDK6 GNA11 BRAF NRAS PTEN MDM2 MTOR CDK4 PMC8745220__F5 Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis COMP MAK PMC7933806__F2 Sphingolipid networks CERK SMS tmp_locus_29 LPP PMC8395582__F5 ErbB signaling pathway map EGF JUN BAD NRG3 MTOR SHE MYC NRG4 NRG2 CRK CBL BTC GRB2 PMC4143607__F5 The role of the PHDs in the cell cycle ATR CEP192 SKP2 PMC6677404__F2 Schematic diagram illustrating a role of PI3K, Rho and ROCK pathways in hypoxia-induced ATP release and ATP-mediated angiogenic effects in vasa vasorum endothelial cells EGR1 FOXO3A ARHA PMC2809919__F2 Epithelial–mesenchymal interactions mediated by the Sonic Hedgehog pathway in the gut FOXF1 SHH SMO GLI3 PMC9524953__F6 Identification of a functional circRNA-miRNA-mRNA regulatory network in infantile hemangioma by bioinformatics analysis TF STAT3 GAL HEL-S-133P HEL-S-162eP EPO NUMB HEL-S-87p HES1 VHL EIF4E HES5 PMC10779236__F5 Possible action mechanisms of sialic acid mediated by the signaling pathway and gut environment GNE TLR4 NQO1 BDNF MYD88 PMC9445361__F6 Score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancer FCRL4 TNF COL2A1 MAGEA4 PMC7699575__F2 Glutathione (GSH) biosynthesis pathway SLC3A2 GPX4 SLC7A11 PMC7699575__F1 Ferroptosis pathway SLC3A2 GPX4 LPCAT3 FACL4 PMC5997503__F5 PLATELET LIFELINE TO CANCER: CHALLENGES AND OPPORTUNITIES TF COX1 VTN PMC10179536__F9 Proposed diagram for the therapeutic effect of PRP improved bladder overactivity induced by OHD in rat model CD44 SOX9 MTOR PMC5240474__F2 Inhibition of the NOTCH pathway by NUMB CDK8 ADAM17 JAG2 NUMB ADAM10 NOTCH2 NOTCH3 RBPJ NOTCH1 PMC4988306__F2 Role of innate immunity in nonalcoholic fatty liver disease progression NLRP3 IL16 TLR4 TLR9 MYD88 PMC10779236__F4 Main molecular mechanisms regulated by sialic acid GNE TLR4 NQO1 BDNF TNF MYD88 PMC8699303__F6 Shooting at Moving and Hidden Targets—Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas HEY2 ECD RIN1 EGFR PTEN MTOR KRAS PMC7308183__F6 Protein–protein interaction network of CFTR (GeneMANIA) CXCL12 HEL113 CCL11 CLCN3 SLC4A7 DNAJC5 NKX3-2 HEL-S-94n EZR CEBPD ADRB2 PRKX CFTR CCL4 PRKAR1B ABCB1 PMC8699303__F7 Shooting at Moving and Hidden Targets—Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas DLL4 PMC8946535__F1 From Biology to Treatment of Monoclonal Gammopathies of Neurological Significance SYK BTK BCR PLCG2 BLNK IRAK2 PTEN LYN IRAK4 PMC5129989__F6 Higher methylation intensity induced by EBV LMP1 via NFKB/DNMT3b signaling contributes to silencing of PTEN gene CSA2 PTEN TRAF2 PMC7503990__F1 Structure and biosynthesis of fucosylated glycans FUT1 FUT8 FUT4 FUT6 FUT2 FUT5 FUT3 POFUT2 FUT7 GMDS POFUT1 PMC9040139__F4 Immunopathogenesis of alopecia areata JAK3 JAK1 PMC9488956__F2 Hermansky–Pudlak syndrome pulmonary fibrosis: a rare inherited interstitial lung disease HPS4 RAB32 HPS1 PMC9455597__F3 PARP inhibitor resistance in breast and gynecological cancer: Resistance mechanisms and combination therapy strategies ATR PARG SLFN11 PMC9468871__F3 Network-based pharmacological investigation to identify the mechanistic regulatory pathway of andrographolide against colorectal cancer MAPK1 HRAS PPARG PDGFRA KIT PTPN11 MTOR SRC PMC9468871__F4 Network-based pharmacological investigation to identify the mechanistic regulatory pathway of andrographolide against colorectal cancer MAPK1 STAT3 PPARG EGFR PIK3R1 PTPN11 KIT PTGS2 MTOR IL6 PARP1 HRAS IGF1 TLR4 CASP3 EP300 KDR MDM2 SRC PMC5438742__F2 MYCN down-regulation by didymin and based on network analyses of our proteomic studies that focused on cancer-related pathways active in NB cells CDC42 ADRBK1 EGF BACH1 EGFR GSK3B HIF1A ATF2 RHO MDM2 MYC RALBP1 PMC7340297__F5 Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients PPARG IL10 GDF8 SLC2A4 NGFR NTRK2 NR1C2 MTOR VEGFA IL6 TRIM63 IRS1 NGF PPARGC1B NR1C1 IGF1 INSR FOXO1 NFKB1 TLR4 PPARGC1A PMC4922562__F1 YAP/TAZ mechano-sensing signaling pathway network MAL ARHA PMC6911977__F5 Metabolic pathway for 2,3-butanediol production in yeast (modified, based on S GPD2 BDH1 HEL-S-4 GPD1 PMC12021614__F2 Multiple mechanisms of circRNA in tumor immunomodulation and immunotherapy SMAD2 SMAD4 PMC10848377__F2 Koetjapic acid molecular mechanism in curbing carcinogenesis BAX SMAD2 SMAD4 BCL2 PMC2121320__F2 MTA family of coregulators in nuclear receptor biology and pathology MTA2 BCAS3 MTA3 HIF1A WNT4 PMC8913720__F1 Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease DKFZp781O1323 CCL16 SMAD2 APC CCR2 GSK3B CCL7 SMO CCL8 CCL2 CTNNB1 PMC2910227__F3 Cellular Functions of Transient Receptor Potential channels BTK INSR PTEN PMC2228275__F3 A signaling network links genes regulated by GCs in CEM cells HDAC1 HEL-S-99n MTHFD1 SRM YAF2 ID1 PIAS2 PMC5891012__F1 Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations EGFR GRB2 PMC3272882__F3 DRD2/GSK3B/DISC1 pathway modified from Beaulieu et al DRD2 DISC1 CTNNB1 PMC8913720__F2 Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease CCL16 CCR2 CCL7 CCL2 IL1B PMC8017015__F2 Regulated cell death pathways in doxorubicin-induced cardiotoxicity TF HMOX1 GPX4 ABCB8 PMC3812667__F1 Bcl-2 inhibition may act directly on tumor cells but may also target the nutrient supply to the tumor by disrupting the blood vessels that form around, and within, the tumor () CXCL1 IL8RB CXCL8 PMC6880955__F1 Signaling pathways of RIG-I-like receptors (RLRs), cGAS, and AIM2-like receptors (ALRs) TBK1 CGAS MAVS AIM2 IRF3 PMC5998602__F10 The schematic illustrates a model of Long noncoding RNA HULC promotes liver cancer cell growth by inhibition of PTEN via autophagy cooperation to miR15a HRAS ATG3 PTEN SIRT1 PMC3891517__F3 Possible mechanisms of opioid receptor-mediated influence of morphine on tumor growth EGF BAD ARHA SRC CCND1 PMC7647673__F1 Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics ELAC2 RNASET2 PMC7647673__F2 Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics AGO4 AGO2 JAG2 RPA1 PMC9696119__F5 Emerging Roles of Type-I Interferons in Neuroinflammation, Neurological Diseases, and Long-Haul COVID TBK1 IFNLR1 MAVS STAT2 IRF9 IRF1 IRF3 IRF7 TRAF3 TRAF6 MYD88 STAT1 TLR3 IFNAR2 TLR4 IFNAR1 TLR8 TLR7 JAK1 TYK2 ACE2 PMC10918910__F1 Mechanisms through which the gut microbiome contributes to oncogenesis TLR4 CYP2J2 AHR CYP1B1 CYP1A1 CTNNB1 PMC10918910__F2 AhR activation by microbiome in the tumor microenvironment APC AHR CYP1B1 CYP1A1 PMC10850140__F7 Exploring the mechanism of action of Sparganii Rhizoma-Curcumae Rhizoma for in treating castration-resistant prostate cancer: a network-based pharmacology and experimental validation study TF SRD5A2 BAD PLAT CDK2 PTEN MDM2 GRB2 PMC3135641__F1 Metabolic target genes of p53 HEL-S-20 TIGAR SCO2 SESN1 GLS2 SESN2 GPX1 PMC7728070__F3 Modulating the autophagic machinery in vascular calcification HDAC1 OGT BNIP3 MTOR PMC6938454__F1 Lab Review: Molecular Dissection of The Signal Transduction Pathways Associated with PTEN Deletion-Induced Optic Nerve Regeneration TSC2 TSC1 GSK3B PTEN PMC5951826__F3 Wnt and Ras-MAPK pathway genes and interacting genes with AURKA, significantly deregulated (DEA) or in the most significantly deregulated gene module (Heinz) in the two cell lines, SW480 and Caco2 DUSP5 AURKA JUN DICER1 LAT PPP3R1 PPP3CA KRAS AXIN2 FOS KITLG UBE2D1 CTNNB1 ALB CDK6 C2 HEL-S-80p PDGFRA CTBP1 PRKCA DDIT3 CASK MAP3K6 LCK PMC4000109__F2 TGFB signalling cascade alterations that lead to prostate cancer BMP6 TGFB1 GDF15 NODAL PMC6066750__F7 Role of Slfn2 in type I IFN signaling IFNAR2 IFNAR1 JAK1 EFS TYK2 PMC7784996__F3 Metabolism of Methylophaga aminisulidivorans SZUA-1124 SI ACR PMC11675822__F2 NPFF and its receptors’ signaling pathways NPFFR1 NPFFR2 NPFF PMC4106421__F2 ARF impinges both on developmental processes (male germ cell development and ocular development in mice) and tumor angiogenesis ATM PMC5516115__F1 Speculative model on changes in carbon flux during P limitation in a diatom cell MAL PC CIT PMC6534125__F2 Systemic Inflammation in Cancer-Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention PAX3 SMAD2 PAN3 PMC6437556__F1 Vitamin D metabolism and signaling NR1i1 DKK4 CYP24A1 LRP6 ARHA RHO HEL-S-70p FOXM1 CYP27B1 CDKN1A DKK1 GC CYP27A1 PMC4773729__F2 Signaling mechanisms through the Janus kinase (JAK)/STAT pathway and action point of a JAK inhibitor tofacitinib JAK3 EPO TPO JAK1 TYK2 PMC9674619__F4 Mechanism of mutp53 in ferroptosis SLC3A2 SLC25A28 BRD7 CDKN1A ELAVL1 GPX4 DPP4 ALOX12 SLC7A11 PTGS2 GLS2 PMC11810975__F3 Synthesis of Primary BAs and Secondary BAs CYP8B1 BAAT CYP7A1 CYP7B1 CYP27A1 PMC10149902__F12 Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis METRNL APOE PMC6199354__F1 Ubiquitin modifications in the TGFB pathway KLF4 CDC42 APC ARHA TRAF6 SKI SAMD5 SAMD7 FBXW7 SAMD1 SMURF1 USP15 USP2 SAMD3 SMURF2 CYLD PMC4761518__F1 F-BOX proteins in cancer cachexia and muscle wasting: emerging regulators and therapeutic opportunities TSC2 GDF8 TSC1 IGF1 MTOR IRS1 PMC6199354__F2 Ubiquitin modifications in the WNT/Beta-catenin pathway WLS USP14 SMURF1 RNF146 RNF43 USP15 APC ZNRF3 SMURF2 CYLD CTNNB1 PMC3589701__F3 The epidermal growth factor receptor (EGFR) signaling pathway and molecules that may affect drug resistance ERBB3 STAT3 HGF ERBB4 EGFR ERBB2 MTOR PMC6920770__F4 Angiogenesis activation through reactive oxygen species (ROS) via hypoxia dependent and hypoxia independent pathways MMP2 PTEN MMP9 MTOR RAC1 PMC7736628__F1 Consequences of STING over-activation on antigen presenting cells and T cells following severe acute respiratory syndrome coronaviruses (SARS-CoV-2) infection TBK1 CGAS MAVS ULK1 IFIT3 IRF3 IRF7 NRF SLC19A1 TNF ACE2 PMC3068308__F5 TGFB signaling pathway SMAD2 SMAD4 PMC7940873__F7 LncRNA-mRNA co-expression network analysis TNFRSF1B FAS PKN1 CSF1 CREB3 TNFRSF1A CXCL1 THBS2 RPS6KB2 PIK3R1 VTN SOCS3 CCL2 CXCL3 EFNA2 MAP2K4 YWHAQ RIPK1 MAPK12 ATF4 TRIB3 CEBPB FGF16 CREB1 BIRC3 JUN CSF2 RBL2 IRF1 CXCL2 MMP9 CXCL10 RIPK3 RELA EDN1 RPS6KA5 CCL20 PMC3043245__F3 Signalling between p53 and the IGF-AKT-mTORC1 pathway RHEB TSC2 TSC1 ATM PTEN MDM2 PMC8796618__F12 MAGEA6 positively regulates MSMO1 and promotes the migration and invasion of oesophageal cancer cells MED8 HMGCR MAGEA6 PC4 MED25 CDK9 MED1 PMC5588408__F1 Canonical and noncanonical inflammasomes NLRC4 NLRP1 NAIP NLRP3 IL16 IFNAR1 AIM2 IL1B PMC9355307__F4 Sex chromosome aneuploidies give rise to changes in the circular RNA profile: A circular transcriptome-wide study of Turner and Klinefelter syndrome across different tissues APRT SLCO4C1 TRAPPC1 RAF1 RAB7A CXCL5 CD46 DYNLT1 VAMP7 MAPK14 MME ZNF175 OSTF1 NHLRC3 BRI3 PTGS1 NRAS TPO GGH MDM2 APAF1 LPL MAPK1 RAB27A IFNGR1 SP1 NAMPT B2M CTSA PSMD13 MNDA HEL114 HRAS RAP2C ACTR2 RICTOR BAG3 VAPA IFNAR1 RAB37 FGL2 ADAM10 PGRMC1 LCN2 PSAP DEFA1B SNAP23 ADAR TBK1 RAB10 CD36 RAB31 MPL IFNGR2 TLR4 SRPK1 CHUK APP CD81 ANXA3 CD55 FTH1 TNFSF10 PMC5495879__F3 Overlap of the present results with Greengard’s neurotransmission integration scheme DLG2 KCNN3 TRPC4 ATP2A2 GABBR2 PPP2R3C PDE4B Nucb2 CHRNB4 GABBR1 CHRNA3 KCNB1 CHRNA2 KCNJ3 CACNA1I DRD2 PPP2R2B HCN1 ITPRIP SCGN SRR CATSPERZ NRGN GRM3 KCNG2 ATP2B2 CALN1 TRPM6 NOSIP PDE9A RGS6 CDK5 GABRA2 PPP2R2A OPRD1 PPP2R3A ADCY1 GNG7 PMC3418560__F5 Schematic representation of a case of malignant myeloid disease evolving in four stages along one pathway TET2 RUNX1 ETV6 ASXL1 EZH2 PMC9574103__F3 Comprehensive analysis of metabolomics and transcriptomics to reveal major metabolic pathways and potential biomarkers of human preeclampsia placenta CYP21A2 AKR1D1 CYP17A1 HSD3B1 HSD17B1 UGT1A10 CYP1A1 PMC7596222__F4 Molecular pathways triggered by eCSF-derived factors EGF SMAD1 DKFZp781O1323 FRS2 APC PTCH1 SHH LRP6 SMO BDNF CTNNB1 FGF2 PMC6951466__F4 Ingenuity Pathway Analysis (IPA)‐based plausibility analysis of candidate single nucleotide polymorphisms (SNPs) GNAS NR1C1 CCR5 RXRA LEPR AGTR1 ADRB2 MMP2 RET CP PMC4961118__F1 Quantification of the input-response function of LAT:Grb2:SOS assembly in TCR signaling ZAP70 LAT GRB2 PMC10312032__F2 Research progress on the kynurenine pathway in the prevention and treatment of Parkinson’s disease HEL-S-90n KMO PMC11715079__F1 Cytoplasmic recognition of HAdV DNA occurs through cGAS sensing TBK1 CGAS PDC TLR9 IRF3 MYD88 PMC11715079__F2 Complement activation pathways and antibody neutralization effects of HAdV infection HEL-S-62p C2 C4A C4B_2 TRIM21 PMC8170089__F1 EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress TGFBR2 IFNG ROCK2 SMAD2 ROCK1 DPP4 ZEB2 NOTCH2 PMC11715079__F3 T-cells mediated adaptive immune responses IFNG RUNX1 APC PCBP1 PMC8170089__F2 EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress NPAS3 ADIPOR2 MAPK7 PTEN PMC4673677__F3 Surviving at a distance: organ specific metastasis ANGPTL4 COX2 SPARC IGFBP4 MMP2 VCAM1 PMC2791157__F3 Decomposition of Gene Expression State Space Trajectories RARA RXRA CDK2 PMC3521191__F1 Biological pathways targeted for therapy in renal cell carcinoma based on a knowledge of the underlying genetic changes and downstream biological consequences PTEN CCND1 VHL PMC10949532__F1 Non-canonical NFKB pathway and its regulation: The non-canonical signaling pathway may be initiated through the binding of a variety of exogenous ligands to their cognate receptors (top right) CD40 STAT3 NLRP12 TBK1 LTBR ZFP91 BCL10 CD27 OTUD7B RELB TRAF3 TRAF2 PMC2989404__F1 Eighteen Insulin-like Growth Factor (IGF) pathway genes, circulating levels of IGF-1 and its binding protein (IGFBP-3), and risk of prostate and breast cancer IGF2R GHRH GHRHR INS GHR SST PMC12034760__F0 FBL promotes hepatocellular carcinoma tumorigenesis and progression by recruiting YY1 to enhance CAD gene expression CAD FBL YY1 RBPJ PMC4172779__F3 Downstream genes chosen from KEGG annotated in Wnt/Beta-catenin pathway SIAH1 ROCK2 APC LRP5 SMAD4 LRP6 ARHA BAMBI SOST STOM CER1 SKP1 NLK PMC3159114__F10 Role of GPx-1 in modulating apoptosis BAX FAS GPX1 PMC7881565__F6 Distinct pathway for internalisation of MSN, MWCNT, and ZnO NPs in CHO-K1 cells: The proposed mechanism involved MSN and ZnO NPs uptake through clathrin-mediated endocytosis ATR NPS MTMR3 ROCK2 DOCK3 HEL70 TUBB RAC1 VPS29 HEL-S-99n CDK6 MRE11A ATG12 RAE1 CDK2 ATM GRB2 M6PR CDK4 PMC8776968__F4 P21-activated kinases in neural cytoskeletal remodeling and related neurological disorders CDC42 CDH2 TIAM1 CYFIP1 SMO CORO1A GPM6A RAC1 PMC7654650__F2 Stem cells and lung regeneration STAT3 KRT5 FOXJ1 FOXN4 ASCL1 CFTR RGS13 KRT4 ASCL3 KRT13 FOXI1 SCGB1A1 PMC7654650__F4 Stem cells and lung regeneration LAMP3 PDPN HOPX AGER BMP4 SFTPC ABCA3 SCGB1A1 AQP5 PMC6528901__F4 Implications of 15‐LOX‐1 in angiogenesis in different models ATF2 CD47 PMC7304922__F1 Activation of Nrf2 and AhR signaling pathways KEAP1 AHR PAH PMC300841__F1 Usurpation of the Ras signaling pathway by reovirus EGFR ERBB2 GRB2 SRC PMC2390552__F11 ERK1 and ERK2 knockdown differently affect signals involved in patterning of the early embryo WWP1 SPRY2 GATA5 SMURF1 SPRY4 FST NOG TBX6 GSC NODAL PMC4584981__F3 Model representing cross talk between drought and pathogen stress signaling pathway from individual stress studies and its relation to shared and unique response pathway provoked under combined stress MYB ERF MYC PMC9240199__F3 Emerging Roles of Human Gut Microbiota in Gastrointestinal Cancer BAX SP1 NRP1 AAG1 MTOR PMC2768997__F1 Human protein-protein interaction network of aging-associated genes MAPK1 SHC1 FEN1 PCNA EGFR NFKB2 PTPN1 IGF1R MYC BLM MAPK3 RB1 HDAC1 SUMO1 NFKB1 IL2 ATM EP300 GRB2 TBP RET PMC6271345__F6 Proposed mechanisms underlying the cellular responses to t-BHP after pre-treatment with Rb1 via Nrf2/HO-1 signaling pathway RB1 KEAP1 NQO1 MAF PMC4375817__F3 The modulation of downstream signaling pathways of the brain derived neurotrophic factors (BDNF) by glucocorticoids (GCs) GC GRB2 BDNF PMC8434356__F11 New Amino Acid Schiff Bases as Anticancer Agents via Potential Mitochondrial Complex I-Associated Hexokinase Inhibition and Targeting AMP-Protein Kinases/mTOR Signaling Pathway BAX BCL2 MTOR PMC7823834__F2 Agents acting on hormone signaling to revert drug resistance in CRC BAX BAD RUNX1 FOXO1 APC PMC2597859__F1 Role of Programmed Cell Death in the Immunopathogenesis of Sepsis BAX BAD FAS TRADD MCL1 FADD PMC8700241__F2 Metabolic Reprogramming of Liver Fibrosis CPEB4 PFKP HK2 FBP1 HIF1A PDK3 PCK1 PMC1440398__F2 CDC maturation upon virus infection MAVS IRF3 FADD PMC3539953__F5 Representation of the “Interferon Signaling” and “Toll-like Receptor Signaling” pathways BAX TIRAP IFIT3 PIAS1 MYD88 PMC4808550__F1 Thyroid hormone-signaling pathway HIF1A MTOR SRC CTNNB1 PMC3981821__F4 Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus ACLY HMGCS1 LIPA ACAT1 HMGCR EBP SOAT2 SQLE COA1 DHCR24 DHCR7 MVK PMC6904332__F3 Upregulation of SESN2 under ERS and its protective effect on ERS-associated cell death TG ELF2 ATF4 EIF2A SESN2 XBP1 TRAF2 PMC6904332__F4 The expression and effect of SESN2 on immune cells NLRP3 SESN2 TNF IL1B PMC3981821__F6 Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus MTHFD2 HEL107 G6PC2 HEL-S-133P HEL-S-51e G6PC3 PGAM1 PGAM2 ALDOB RPIA HEL-S-68p HEL-S-49 PGM2 HEL-S-162eP FBP1 SHMT1 ENO1 PSAT1 GCK PFKL HEL-S-87p PKLR PSPH PRPS1L1 PMC2435618__F2 Pathways involved in cell differentiation, homeostasis and apoptosis in the adult intestinal epithelium, Beta-catenin and TCF4 are expressed in the proliferative compartment, where are located the intestinal epithelial stem cells SHH IHH TCF4 PMC12191890__F5 Calcium signaling regulation in keratinocytes CASR JUN TRPC1 ATP2A2 FOS PMC12191890__F6 Signaling pathways regulating epidermal homeostasis RHEB BAX EGF TSC2 ATR JUN TSC1 JAG2 BCL2 ATM PTEN NOTCH1 PMC9089305__F8 Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway HMOX1 KEAP1 GCLC PMC9025760__F2 Characterization and Roles of Membrane Lipids in Fatty Liver Disease MFN2 PEMT PC PMC9099743__F1 Advances in Understanding the Genetic Basis of Fatty Acids Biosynthesis in Perilla: An Update DGAT1 DGAT2 PC PMC10538549__F3 cGAS-STING signaling pathway in intestinal homeostasis and diseases CGAS IL1B PMC10538549__F1 cGAS-STING signaling pathway in intestinal homeostasis and diseases SLC46A2 STAT3 TBK1 CGAS STAT2 IRF9 IRF3 IFI16 SLC19A1 ENPP1 TYK2 IL1B PMC10538549__F2 cGAS-STING signaling pathway in intestinal homeostasis and diseases IL10 LAT MUC2 IL18 IL4 MUC1 AREG IL5 TFF3 PMC11012409__F1 Agnostic Administration of Targeted Anticancer Drugs: Looking for a Balance between Hype and Caution BRCA1 NTRK1 BRAF NTRK2 NTRK3 RET PMC4373890__F2 Towards Anatomic Scale Agent-Based Modeling with a Massively Parallel Spatially Explicit General-Purpose Model of Enteric Tissue (SEGMEnT_HPC) STAT3 DKK1 TLR4 PTEN CTNNB1 PMC4313349__F1 Nutrient Sensing Mechanisms and Pathways HMGCR CD36 VCP PMC7465272__F1 STAT activation pathway with opportunities for inhibition SOCS1 BAX OSM EGFR LIF EPO SOCS2 MTOR CS SOCS3 NOX4 ADAM17 FOXP3 GRB2 SRC PMC6321520__F1 Expression of Insulin/IGF signaling components is modulated by miRNAs BAD PHLPP1 IGF1 PTPN1 PTEN GRB2 MTOR KRAS IGF2 IRS1 PMC5907833__F3 Regulation of KLFs in ECs KLF4 TIEG2 KLF2 PMC7934645__F2 Regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases TF HDAC3 VEGFC TIMP3 FOXC2 NCOR1 FOXQ1 EGFR FOXF2 IRF2BPL SFRP1 CTNNB1 PMC7934645__F3 Regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases SPOP KIF7 SUFU SMO FOXF2 PMC4796284__F1 Postulated mechanism of PDGF-C-mediated liver fibrosis and tumor in Smad3-dependent and -independent signaling pathways PDGFRA PMC4074033__F6 Kaposi Sarcoma Herpes Virus Latency Associated Nuclear Antigen Protein Release the G2/M Cell Cycle Blocks by Modulating ATM/ATR Mediated Checkpoint Pathway ATR ATM PMC7934645__F1 Regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases SMAD1 SP1 BMP4 FOXF2 PTEN ZEB2 PMC8125482__F3 Multifaceted Roles of USP15 in Signal Transduction USP15 MDM2 MTOR PMC4988688__F2 Hedgehog (HH) signaling pathways SUFU PTCH1 SMO PMC4988688__F3 Activation and molecular crosstalk amongst signaling pathways EGF SUFU EGFR LRP5 BRAF LRP6 SMO PTEN AXIN2 CTNNB1 PMC9315126__F5 Phosphoproteomics identifies pathways underlying the role of receptor‐interaction protein kinase 3 in alcohol‐associated liver disease and uncovers apoptosis signal‐regulating kinase 1 as a target HEL-S-31 FAS PYCARD CASP8 TRADD IKBKE ACIN1 GAS2 CRIPT DFFB TGFBR2 RP1 PIG59 ZBP1 BAG3 DFFA RP2 CASP3 BCL2 MAP3K7 AIFM1 LMNA FADD PMC8326438__F10 Exploring effects of DNA methylation and gene expression on pan-cancer drug response by mathematical models TRIM13 FLT3 RAN RCC2 VAMP3 ACADM TMED10 BCR CAMK2N1 SRGAP1 RBPMS NOL3 PTGS1 ABCC3 TFAP2C CHST13 HELB AREG AKR1C1 IGSF3 RHEB RHBDF1 CD63 SNAP23 VEGFC TRIOBP CABL1 TRPC1 ATXN2L XBP1 SHANK3 CTCF CLU MRPS30 SYNM DAG1 THBS1 VPS37D FH TAF4B KIT CD19 ARHA BCL11A RAC1 CAP2 DLAT GPR132 LIAS ACVR1 LMCD1 GMFG CRIM1 WFS1 RASSF2 NASP SYK RAB17 PRKD1 SCARA3 PTPRF HEL-S-25 CTSZ CHSY3 RPS3A GPN3 BRI3 ARID2 HSPB8 AQP11 RRP1 SYDE1 GOLGA5 CAST HEL-S-43 ZNF169 PNN ARMC9 FRMD5 TMEM106B RHOBTB1 CYB5R1 TMEM132A DCLK2 NGRN TGFBR3 ILF3 ZNF414 SLC35F5 PHIP C1QL1 RPUSD2 ACSS1 TMBIM1 TRABD ARHGAP5 CREG2 PLEKHH1 NPEPL1 MCM6 LAMA3 BIRC7 HGF FASTK EGFR CTNND1 AMOTL2 WIPF1 PTEN AHNAK2 CD37 ARHGAP21 SHISA4 HMGB1 GPC1 CD2 ARHGAP29 FTH1 PGM3 PRP4K HNRNPC PMC4002948__F7 Possible molecular mechanisms by which Alpha-TOS overcomes the resistance of erbB2-expressing cells to apoptosis and sensitizes them to hrTRAIL-induced apoptosis HEL-S-62p C9 ERBB2 PMC11594131__F5 Possible ways of protective action of MKs and MKT in signaling and metabolic pathways under oxidative stress and heavy physical exercise NR1C1 PINK1 PDK4 MTOR NRF1 SIRT1 PMC1832185__F2 Dose-dependent entry routes for the EGFR EGF EGFR PMC7696406__F8A 8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells MAX ECSIT FAS TRADD CD14 TNF DAO MEF2C PMC8468661__F7 Mitochondrial Disruption by Amyloid Beta 42 Identified by Proteomics and Pathway Mapping LETM1 SLC25A13 PLA2G3 CPNE1 DSG3 CADPS2 ALB SLC25A24 SLC25A12 PAFAH1B1 TRPV2 MYL12A HEL-S-69p FKBP1A MYH9 PKIA FAT1 SSR4 PMC7610307__F3 GSK 3B regulates the key signaling proteins of the Wnt pathway APC GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC7460588__F1 Canonical Wnt signaling pathway BCL9 SIAH1 RNF43 DKK1 APC LRP5 ZNRF3 LRP6 CCND1 LEF1 PMC4163887__F1 Role of Toll-like receptors during RSV infection TLR3 TLR4 TLR7 MYD88 PMC7610307__F4 Tumor inhibitory role of GSK 3B GSK3B PTEN MIF CCND1 CTNNB1 PMC9266588__F3 Amino acid biosynthesis in Cyclocarya paliurus HEL107 HEL-S-162eP CS PMC7435507__F1 Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection CAD HEL-S-62p UMPS DHODH PMC7903655__F2 Mechanism by which MSCs regulate macrophage polarization in the context of SCI CCR5 CCR2 ARG1 CCL5 CCL2 PMC6299067__F2 Lysophosphatidic Acid 's effects on ion channel regulation LPA TRPV1 RHO PMC8998506__F3 Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer’s Disease CCPG1 RTN3 BACE1 ATL3 XBP1 PMC5348391__F9 Neurokinin-1 receptor is a novel positive regulator of Wnt/Beta-catenin signaling in melanogenesis APC GSK3B CTNNB1 PMC4673168__F5 ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma NF1 GNA11 BRAF KIT GRB2 AREG MTOR PMC7683158__F2 SUMOylation in the hypoxia pathway CBX4 SENP3 HDAC6 PMC7683158__F3 SUMOylation in the nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) pathway CSA2 ATM SENP2 PMC2717887__F2 Clusterin as a critical signaling node TGFBR2 MMP25 JUN JUND LEP MYBL2 CLU PON1 VTN CTNNB1 PMC12150400__F3 Interaction between Trp metabolites and OA SOX9 COX2 SMAD2 ADAMTS5 MMP3 AHR NOX4 SIRT1 PMC1934514__F4 Schema outlining the signaling mechanisms reported to be involved in GLP-1R-induced differentiation/neogenesis of pancreatic precursor cells, proliferation and in the prevention of apoptosis PI3 EGFR BTC BMP2 MTOR PMC12150400__F4 Interaction between Trp metabolites and OP PRMT1 SMAD1 HGF NSD2 PTEN NFATC1 MTOR RUNX2 TRAF6 SIRT3 SMURF1 NLRP3 BMP2 AHR ATF4 SIRT1 PMC1934514__F2 Mechanisms of Action of GLP-1 in the Pancreas EGF FOXO1 PI3 HEL-S-11 MTOR PMC12150400__F6 Interaction between Trp metabolites and AS CRP STAT3 IL10 FOXP3 TNF PMC12150400__F1 Three pathways of Trp metabolism in the human body KYNU KMO AANAT ASMT PMC12150400__F2 Bioactive effect of Trp metabolites in bone-related cells CXCL12 SMAD1 ADAMTS4 PCNA GAS AANAT SMAD4 NFATC1 RUNX2 SOX9 FOXO3A COA1 ACKR3 MSC AHR CXCR4 CTGF SIRT1 PMC2777399__F1 Regulatory mechanism of the Rho/ROCK pathway activated by angiotensin II (ANG II) in vascular smooth muscles cells (VSMCs, see text) EGFR ARHA SLK PMC11311281__F4 PAR2-induced Beta-catenin stabilization and targets of RNF43 RNF43 PTEN CTNNB1 PMC8705244__F2 Alterations in Kynurenine and NAD+ Salvage Pathways during the Successful Treatment of Inflammatory Bowel Disease Suggest HCAR3 and NNMT as Potential Drug Targets ART3 HTR1F NAPRT PARP16 HTR4 PARP8 AANAT ASMT AFMID SLC7A5 MAOA NMRK2 TPH1 NNMT HAAO AHR TPH2 TIPARP AADAT NMNAT3 PARP10 GOT2 INMT HEL-S-90n PARP14 KYAT3 KYNU NMNAT1 KYAT1 KMO SIRT5 NAMPT NMNAT2 DDC HCAR3 NMRK1 HTR3E HTR3C IDO1 PARP3 NADSYN1 PMC3670237__F2 STAT3 regulation of and by microRNAs in development and disease STAT3 JUND JAK1 SRC PMC6402958__F7 Models of TGFB superfamily signaling and Harmine-TGFB superfamily actions on human beta cell proliferation CDC2 FOXM1 DYRK1A GDF11 E2F2 MEN1 SMAD2 SMAD6 SMAD4 CDK2 MYC PMC4003231__F1 Immune pathogenesis of gastric mucosa damage in H CCL20 FADD PMC3589238__F6 Networks wherein various signaling pathways epigenetically affected by MXC exposure intersect and the relationships between affected molecules MAX HRAS IGF1 INSR PGR SMAD2 PTEN IGF1R CP PMC6333638__F3 Cell-intrinsic PD-L1 in modulating signaling pathway BMI1 STAT3 MTOR C4A PMC3958665__F6 KEGG pathway for Huntington's disease (proteins identified in our study of the PBMC proteome are highlighted by red stars) BAX REST HEL70 TAP2 TBP SET PMC6319582__F7 Diagram of knockdown of TFPI-anchored endothelial cells induced a more severe LPS-induced acute lung injury via NFKB signaling pathway TFPI TLR4 VCAM1 TNF ACE2 PMC5751326__F1 InterferonB (IFNB) signaling pathways and autocrine/paracrine loop STAT1 AFF2 STAT2 TLR4 TLR9 IRF3 TLR7 TRAF3 TRAF6 IRAK4 MYD88 PMC5751326__F2 Role of IFNB in host–pathogen interaction in Mtb infection TBK1 CGAS NLRP3 AIM2 IRF3 IL1B PMC7683158__F1 SUMOylation pathway BRCA1 PTEN MDM2 MYC CTNNB1 PMC9171887__F1 SARS-CoV2 and mitochondria: the impact on cell fate MCL1 BCL2 ATF2 PMC2639747__F2 Smad3 in TGFB–mediated proapoptotic transcriptional responses GADD45B BCL2 MTOR PMC5473921__F2 Network of organismal abnormalities and cancer S100A1 CALD1 RPN2 S100A16 LPXN TOMM40 GLRX S100P HSD17B12 TMSB10 PMC2639747__F1 Smad3 in TGFB–induced antiproliferative transcriptional responses SP1 E2F4 SMAD4 E2F5 PMC7831445__F3 The innate immune response to human coronavirus infection TMPRSS2 NOS2 TBK1 CGAS MAVS STAT2 IRF9 IRF3 IRF7 MYD88 STAT1 TLR3 TLR8 TLR7 ISG15 JAK1 TYK2 ACE2 PMC8505811__F2 Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease CS TRAF6 PMC8505811__F1 Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease SMAD2 SMAD4 NFATC1 MTOR TRAF6 PMC3859915__F2 Signaling downstream IL-2/IL-15RB JAK3 MTOR JAK1 PMC3376493__F4 A Human Homeotic Transformation Resulting from Mutations in PLCB4 and GNAI3 Causes Auriculocondylar Syndrome GNAI3 PLCB4 DLX6 EDN1 EDNRA PLCB3 DLX5 PMC7865811__F3 NFKB pathway by NLRX1 NLRX1 MAVS TRAF6 MYD88 PMC6291014__F1 Signaling pathways linking EphA and RhoA in regulation of cell adhesion/repulsion CDC42 PAK1 ARHA RHO SRC PMC7572606__F1 MYC transcriptionally upregulates the glutamine metabolism pathway ADAR GLS TXNIP SLC25A10 FBL ACACA MTOR HEL-S-51e MYC MYD88 ELF4 UBA2 TFF1 SUMO3 PARP12 HLA-E NOP56 RIPK1 ATF1 PSME2 FAT10 SMARCC1 CAD SP1 STAT2 HK2 RRM2 PLAUR OAS3 HEL-S-70p BTN3A3 SAE1 ADSL CSDE1 LAMP3 ZC3HAV1 PAICS TRIM25 SLC25A11 MVP OGFR NFKBIA SLC25A39 PFAS HEL-75 PMC6291014__F4 A model of EphB forward signaling regulating cell-ECM adhesion EPHB2 MMP2 RAC1 PMC5706935__F1 PARK2 loss connects AMPK-mediated nitrosative stress to PI3K/AKT activation CAMKK2 EGFR PTEN SRC PMC6009929__F1 Synthetic pathway for preparation of II-V [reagents; i = NC-CH2-CN, ii = (CH3CO)2CH2, iii = (NH2)2C = NH, iv = NH2NH2, v = MeI] COCH CPD PMC8076597__F1 Road of Solid Tumor Survival: From Drug-Induced Endoplasmic Reticulum Stress to Drug Resistance BAG3 ATG12 HSF1 RIPK1 MAPK9 TERT ATF4 MAPK8 ATG5 XBP1 TRAF2 CTNNB1 PMC3286676__F1 Thyroid iodide efflux: a team effort? TG TSHR TPO DUOX2 PMC4867322__F1 The Hippo signal transduction network and its links to exercise-associated signals and signalling modules LATS1 MCAT TSC1 BAG3 TEAD2 TEAD3 PTEN MAP2 VGLL4 TEAD4 PMC3742302__F6 Omics-Based Molecular Target and Biomarker Identification ATR ATM MDM2 CDC25B PMC3630382__F7 Ingenity Pathway Analysis (IPA) from genes with loss of heterozygosity and somatic mutation (sample G05) TRIM13 GATA2 GPR162 KPG_011 MED4 HTR2A MAST2 RB1 MLNR KPNA3 GPR174 VN1R2 DLEU7 TAAR8 PMC3630382__F8 "Cancer, Hematological Disease, Cell Cycle" Network GATA2 PROK1 RPS6KA1 GH1 MNDA MAST2 CREG1 UBN1 RAD21 CEBPA INSRR NPM1 NGB RNF112 TRA2B EMCN TLL2 PMC3630382__F9 Major interaction in top network GATA2 CEBPA ARHGEF5 NPM1 TRA2B PMC5098112__F6 Manually curated version of RISN BAD BOLA1 APC PMC9609926__F4 Activation of Host Cellular Signaling and Mechanism of Enterovirus 71 Viral Proteins Associated with Hand, Foot and Mouth Disease MAVS TLR3 STAT2 IRF9 TAB3 TANK IRF3 IRF7 TRAF6 TYK2 FADD PMC8601392__F4 Dynamic Interaction Between Mucosal Immunity and Microbiota Drives Nose and Pharynx Homeostasis of Common Carp (Cyprinus carpio) After SVCV Infection MADD CD40 tal-1 TRIM25 APP CLPS PMC8987327__F5 Prolyl hydroxylase domain proteins in bone metabolism TET2 BRD4 TET1 CDK9 PMC9042931__F4 Protein–protein interaction networks between NAD+ and associated regulatory proteins implicated in heart aging STRADA BAX SIRT3 FAS RELA MTOR INS FADD PMC8592830__F1 Regulatory host factors and interacting viral proteins of the RLR-mediated antiviral signaling pathway OTUD4 OGT GSK3B TRAF3 PLK1 HDAC3 TRIM24 RNF115 TIPARP CYLD DYRK2 UBQLN2 USP19 MFN1 UBE2S IRF3 IRF7 HEL-117 c-fgr FOSL1 UBXN1 PLP2 RNF166 SMURF2 GPATCH3 WDR82 PLA1A RNF128 TBK1 TTLL12 ASB8 MAVS ITCH IFIT3 TRIM35 HEL-S-276 TRIM21 YOD1 TRIM9 MSX1 OTUB2 TRIM31 MYSM1 RNF5 LGALS3BP PCBP1 NLRP2 TRIM25 NLK LCK PMC9042931__F2 Schematic diagram illustrating intracellular pathways of NAD+ synthesis, NAD+ metabolism, and NAD+ signaling pathway in mitochondria BAX NRK SLC29A4 SLC29A3 NAMPT SLC12A8 SLC5A8 SIRT3 SLC25A51 NADK SLC29A1 NNT NMNAT3 PMC3976587__F7 Post-Transcriptional Regulation of Cytokine Signaling by AU-Rich and GU-Rich Elements CDC42 TNFRSF1B TRADD TNLG7A TANK STK4 IRAK1 IRAK2 SOCS3 MAPK8 TRAF6 TGFBR1 MYD88 TGFBR2 RIPK2 RIPK1 TIFA CEBPB JUN CITED2 CASP8 CASP2 SP1 TNF RUNX3 RIPK3 RUNX1 MAP3K7IP1 TRAF5 BCL2 TNFSF10 PMC8592830__F2 Regulatory host factors and interacting viral proteins of the cGAS-mediated antiviral signaling pathway TBK1 CGAS AGO2 ZDHHC1 RBCK1 TRAF6 PIN1 OTUD1 ENPP1 NSD3 HSPD1 TRIM28 RNF115 USP18 IFITM3 OTUD5 AMFR SENP2 ATF4 USP21 DDX56 CYLD USP44 NMI DDX5 RNF5 PTPN1 IRF1 IRF3 IRF7 USP49 NLRX1 ATG9A CSK USP22 USP20 TRIM29 SNX8 PMC2563180__F3 The cardiofaciocutaneous syndrome HRAS BRAF KRAS PMC3045531__F9 Snail repressor is required for PMC ingression in the sea urchin embryo HEL23 MB PMC7307344__F1 LncRNAs in osteosarcoma via PI3K/Akt signaling pathway PMC1899931__F8 Theoretical model depicting potential interactions in the intra-S checkpoint signaling pathway TOPBP1 ATR ATRIP TIMELESS PMC4996735__F1 Redox signaling: an evolution from free radicals to aging KEAP1 NQO1 SRC PMC8978522__F6 RING finger protein TOPORS modulates the expression of tumor suppressor SMAR1 in colorectal cancer via the TLR4‐TRIF pathway STAT3 TLR4 TOPORS IRF3 TRAF3 PMC6726644__F9 Schematic overview of metabolic pathways of P REST HEXA AMT HEL111 DAP DMPK PMC7901903__F1 Gasdermins in pore formation and pyroptotic cell death GSDMD GSDMB DFNA5 RHO GSDMA PMC4303254__F3 Gene product interaction network of immune and inflammatory responsive genes associated with smoking in females generated from the information in the Ingenuity knowledge base, version 7.6 LTK TBXA2R KLRB1 PBX1 KIF20A DNM3 AUTS2 GNAZ CHCHD2 PPP2R2B DLG5 PROS1 HEL-S-133P TNFSF6 RGS6 KLRG1 ACRBP PRSS23 GRB2 GGTA1 CACNA2D2 RAB6B ZFYVE28 TXK MYRIP KLRF1 SMOX PHLDB2 DNAH12 GPR15 SH2D2A NCR1 MYLK SLAMF7 F2R CLU GNLY MYBL1 SPON2 PRDM5 PDGFA GZMA F13A1 PRNP ME1 PTGDR GPR68 ELL3 NR2A1 RAB27B NMUR1 BMP2 CCR4 DHRS2 PF4 PMC8822281__F6 miR-3132 upregulates surface TRAIL to induce apoptotic cell death in cancer cells TBK1 IRF9 IRF3 MYD88 PMC8226237__F3 Machine Learning Approach to Differentiate Two Specific Breast Cancer Subtypes Using Androgen Receptor Pathway Genes NONO HSPA4 RANBP9 RUNX2 TRIM68 PMC12075064__F2 Pathway insertion strategy into a Δadh P TH BAD HBD PMC6441206__F3 Regulatory network of ferroptosis IREB2 VDAC3 PHKG2 CDO1 KEAP1 GPX4 BAP1 SLC7A11 EGLN1 CISD1 IPP LOX MT1G PMC138699__F1 Simplified diagram of the canonical Wnt/Beta-catenin signaling pathway APC GSK3B CTNNB1 PMC11960914__F9 Schematic diagram of PHB1 and PHB2 expression in blood vessel wall cells and the possible molecular pathways in terms of adhesion of ECs and proliferation, migration, and autophagy of VSMCs VCAM1 MMP9 MTOR CCND1 PMC8026611__F7 Ferroptosis: molecular mechanisms and health implications STAT3 SLC3A2 RAB27A IL10 IFNGR1 TGFB1 GPX4 ARG1 SLC7A11 IFNG STAT1 IFNGR2 AGER JAK1 ATG5 PMC8026611__F2 Ferroptosis: molecular mechanisms and health implications TF VDAC3 SLC3A2 SLC40A1 RAB7A GPX4 LPCAT3 SLC38A1 FACL4 SLC7A11 ACACA PEX10 PEX3 POR TXN TFRC CHMP6 TPD52 DPP4 SLC11A2 NOS2 CHMP5 AIFM2 SQLE FASN CTH FTH1 FTL HMGCR STEAP3 GCLC HEL110 FDFT1 GLS2 HEL-S-64p ADA PMC4561113__F3 Notch-signalling pathway in macrophage reprogramming and its interaction with the TLR-dependent signalling pathway TF STAT3 TLR4 SOCS3 IRF8 PMC3875397__F1 FOXO transcription factors throughout T cell biology RHEB TSC2 KLF2 TSC1 ATM PTEN CTLA4 FOXP3 BCL6 PMC8026611__F5 Ferroptosis: molecular mechanisms and health implications SLC40A1 KEAP1 GPX4 GCLM SLC7A11 FECH HMOX1 FTH1 FTL ALDH3A1 GCLC MAF NFE2L2 MT1G HEL-S-64p HEL-75 PMC3635988__F12 HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1 IFNAR2 IFNAR1 IRAK1 IRF7 MYD88 PMC1862519__F1 Intracellular signaling cascades activated by BDNF-stimulated autophosphorylation of TrkB receptors may affect prominent pathways responsible for elevations of intracellular Ca2+ levels in neurons PI3 GRB2 SHE BDNF PMC3640296__F2 Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches CD44 STAT3 HK2 HEL-S-28 CXCR4 CTNNB1 PMC3640296__F3 Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches STAT3 IGF1 HEL-S-28 MTOR CXCR4 CTNNB1 PMC8906750__F1 Monolignol pathway metabolite levels in the C. hassleriana seed coat CAD DAP PMC6635480__F1 Targeting pathways and molecules in the treatment of NMSC BAD SUFU PI3 EGFR SMO MDM2 MTOR PMC9366312__F3 Overcoming Mycobacterium tuberculosis through small molecule inhibitors to break down cell wall synthesis INHA HEL-S-5 PMC9231138__F11 Dihydrotanshinone I Enhances Cell Adhesion and Inhibits Cell Migration in Osteosarcoma U−2 OS Cells through CD44 and Chemokine Signaling CD44 STAT3 FOXO1 IL6 CXCL8 PMC10855920__F2 Innate and adaptative immune systems TLR3 TAB3 IRF3 TRAF3 TRAF6 MYD88 PMC10855920__F4 Molecular pathways hypothesized to be involved in the pathogenesis of nonspecific orbital inflammation IFNG CXCR3 IL33 IRF3 TRAF3 TRAF6 TNF CCL17 MYD88 PMC8283099__F5 Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude IFNL4 IFNL3 HEL-75 PMC9102749__F6 System-level investigation of anti-obesity effects and the potential pathways of Cordyceps militaris in ovariectomized rats TF POR RARA HEL-S-130P BCL2 SHE DAO KRT19 PMC12065145__F7 Schematic diagram illustrates the mechanism by which high Hcy levels promote hypertension GPX1 PMC4395781__F6 Representation of the proposed mechanism of action for CM-hfMSCs on insulin-like growth factor (IGF)-expressing cells IGFBP2 IGF1R CCND1 IRS1 PMC9035223__F1 Fleshy fruit ripening: from transcription factors to epigenetic modifications MYB ERF ARF4 PMC10474116__F3 Pathways of mitochondrial quality control YME1L1 ATF5 CLPP BNIP3 ATF4 FUNDC1 NRF1 PMC1974879__F1 Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src TGFBI ALOX5 TFPI FST FHL1 AHNAK SRC PMC108887__F9 The CD5-induced signaling pathway, which is mediated by PI 3-kinase and Vav, resulting in the activation of Rac1 FYN CD5 LCK PMC4145816__F1 Ras/MAPK signaling cascade and small molecule inhibition SOS1 BRAF GRB2 PMC8541918__F4 Compartmentation of the Wnt pathway by LLPS APC GSK3B LRP5 LRP6 CTNNB1 PMC8541918__F5 Phosphorylation regulates Hippo pathway LLPS LATS1 LATS2 WAS PMC10474116__F4 Apoptotic signaling pathways BAX APAF1 BIK FADD PMC4456143__F2 Alterations in DNA Methylation May Be the Key to Early Detection and Treatment of Schistosomal Bladder Cancer SOST APC GSK3B LRP5 LRP6 CTNNB1 PMC5097896__F6 The Activin/TGFB mediated Smad2/3 signaling pathway SMAD4 NODAL PMC10751868__F5 H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer HNRNPA2B1 SNAI1 PMC8716617__F2 Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells PANX1 PIEZO1 THY1 ARHA RAC1 PMC8506768__F6 Bioinformatic analysis of differentially expressed genes and pathways in idiopathic pulmonary fibrosis BAX RAN BAD HGF RASSF1 POLK EGFR JAK3 FHIT RET PMC3634910__F1 Nutrient Signaling to mTOR and Cell Growth RHEB TSC2 TSC1 NF1 TBC1D7 PTEN GRB2 PMC3634910__F2 Nutrient Signaling to mTOR and Cell Growth RHEB TSC2 TSC1 TBC1D7 MTOR PMC3634910__F3 Nutrient Signaling to mTOR and Cell Growth RHEB TSC2 TSC1 TBC1D7 PMC9138746__F3 Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer CRIPTO GSK3B A2M PLK1 FADD PMC7057487__F4 Interactive network for the 8 enriched signaling transduction pathways GRIA2 ATP2B1 THBS2 GSK3B BRAF PLA2G3 PRKCZ IGF1R PPP2CA MC2R PLA2G2E MYLK3 NRG4 GNB1 PLA2G10 SHC4 ADCY9 PLCG2 NF1 PDGFC FGFR1 ACOX3 KCNMA1 MAPK1 TAOK1 CACNA1C ATP2B2 LAMC2 KIT CCM1 IL1A ITGA2B RELN NRG2 TSC2 ITGB1 TIAM1 BRCA1 PLA2G6 CACNA2D1 EDNRB CREBBP MAPK10 NFATC3 GRB2 GLI3 PMC7840724__F8 Schematic model for radiation induced opposite invasion and migration potential in HCT116 and DLD-1 cells ANXA2 GSK3B PMC4931107__F1 snR81 box H/ACA RNP-catalyzed pseudouridylation NHP2 GAR1 GC NOP10 PMC2955618__F6 Runx2-regulated cancer-related gene network ST14 EDN2 IL3 SPDEF PMAIP1 MYC SKP2 SLC16A3 SIDT2 BAMBI CTDSPL TOB1 PTGS1 SNAI2 CSF2 POLE2 SLPI CST7 EZH2 VEGFA RUNX3 NR2F1 NKX3-1 ATF3 BARD1 CEBPA EPHX1 CDCA7 LCN2 DLG2 RGS2 SLC40A1 VRK1 CDC6 CD82 SPHK1 AACS HTRA1 RUNX2 NPTX2 MERTK GRIN3A PGC HIPK2 SHBG LYAR GDF15 GBP2 ITIH4 PSMC3IP ACHE LRP8 THBS1 E2F2 DMBT1 SMAD6 SPSB1 MAFB GJB2 STS GMNN RUNX1 LOXL4 TFPI PTGER4 VTCN1 TNFSF10 TM4SF1 PMC7864581__F7 Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling HEL-S-162eP MIB1 USP9X RUNX2 NOTCH1 PMC2724780__F1 Bile acid modulation of death and survival transduction pathways CASP9 BAD CASP3 FADD PMC3899118__F5 Genome Wide Expression Analysis Suggests Perturbation of Vascular Homeostasis during High Altitude Pulmonary Edema TSHR FZD9 PRKAG2 DSG4 ACADM CCL24 FGF7 SSTR2 UTS2 EDNRA MAP2K2 NFATC3 CPT2 PMC7450103__F1 Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target PAICS HEL-S-70p PFAS ADSL PMC7814972__F1 Deoxynivalenol (DON)biosynthetic pathway TRIL MVD FDPS MVK PMC7189445__F1 Hexosamine Biosynthetic Pathway (HBP) and O-GlcNAcylation OGA OGT PGM3 NAGK PMC6361427__F8 Fine mapping of the major QTL for seed coat color in Brassica rapa var. Yellow Sarson by use of NIL populations and transcriptome sequencing for identification of the candidate genes CAD PDC PMC11413889__F9 MetaCore pathway analysis of Schlafen 5 (SLFN5) co-expressed genes in COAD patients from TCGA CAST PNP STAR RAP1A TNFSF10 CCL2 CXCR4 PMC4742192__F10 Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer BAX CASP9 CASP3 ATF4 EIF2A PMC5891592__F2 CXCR4–CXCR7 crosstalk affecting signaling pathways CXCL11 CXCL12 MIF CXCR4 PMC10531073__F3 Fluconazole-Induced Protein Changes in Osteogenic and Immune Metabolic Pathways of Dental Pulp Mesenchymal Stem Cells of Osteopetrosis Patients RAB10 ATP2B3 MYADM ANXA6 HEL-S-7 ANXA1 ATP2A2 HEL70 PGAM4 RB1 CPOX PYGL MB PMC10958717__F2 Oxidized lipids and cholesterol affect MSC differentiation EGF EBP MSC RUNX2 PMC6168163__F2 Maintaining maximal metabolic flux by gene expression control CRP TF ELL PMC5022012__F4 An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population KCNC2 AKAP5 PRKACG IQGAP1 PMC6522716__F5 Differential expression and bioinformatics analysis of circRNA in osteosarcoma IPP PI3 PTEN PMC11638432__F6 The mechanism of PTX3 regulation of innate immunity and ferroptosis after LPS challenge PTX3 CCR6 CCL20 PMC5022012__F3 An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population AP2M1 TP73 ARNT2 KCNQ2 USP2 HSPA4 NR3B3 CP PMC9121581__F5 Potential effects and mechanisms of hispidulin in the treatment of diabetic retinopathy based on network pharmacology SYK TSC2 BAD BCR CD37 RBL2 CYC1 CD19 PTEN MDM2 MTOR EIF4E PMC8775349__F1 Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation CD83 KLRG1 SMAD2 CD14 IRAK1 FOXP3 IL1B GATA3 PMC2981611__F1 Wnt Signaling and Mammary Stem Cells ROR2 LRP5 LRP6 RYK SRC CTNNB1 PMC5120243__F5 Network model for CTNNB1 and related genes HGF EPHA2 EGFR CARD11 GSK3B CTNND1 IQGAP1 SMAD4 MYC CTNNB1 CTNND2 EPHA8 SNAI1 GC SI NR5A2 CCND1 NOTCH1 SS18 SMARCA4 JUP MSH3 APC PTPN1 ARHA TCF7L2 ICE1 PTCH1 ERBB2 CREBBP CTNNA1 LEF1 TWIST1 PMC8909289__F1 miRNA-Dependent Regulation of AKT1 Phosphorylation EGF TENT2 PIK3C2A PMC12204025__F2 Canonical insulin signaling pathway INSR GSK3B IRS1 PMC9129976__F3 Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway SYK TNKS2 MPG ABCC1 EGFR MCL1 NEK2 BACE1 NR1C2 MPO MYLK UBA2 PYGL CA12 ALK PRKCE SHBG INSR F2 NR3A2 PTGS1 AHR MMP2 APP ALOX12 KDR SRC BCHE TOP2A CA14 NR1H3 AXL CA13 FABP4 PTGS2 ESRRA RORC PTPRS HEL-S-130P AURKB BRD2 PMC9459425__F1 Cold adaptation strategies in plants—An emerging role of epigenetics and antifreeze proteins to engineer cold resilient plants CBL ICE1 PMC9129976__F4 Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway PPARG NOS2 EGFR PTGS2 MMP9 MPO RORC NR1C1 PTPRS INSR F2 PTGS1 MMP2 MMP3 AHR HEL-S-11 ABCG2 ABCB1 PMC12239985__F3 Hypoxia-inducible factor 1-alpha (HIF-1A) signaling pathway TF HMOX1 EGF HEL-S-133P EDN1 EPO ENO1 PFKL HEL-S-87p PMC2601664__F1 Membrane-initiated Estrogen Signaling in Hypothalamic Neurons EGF HBEGF EGFR SRC PMC8790028__F3 Opioids Regulate the Immune System: Focusing on Macrophages and Their Organelles CCR5 TLR9 MYD88 PMC4450349__F1 Of flies, mice and men: Evolutionarily conserved tissue damage responses and aging MYC UNK PMC7471874__F11 Expression patterns of genes in IL-1 Signaling Pathway upon EI24 silencing ECSIT MAP3K7IP1 TRAF6 MYD88 PMC6041899__F7 Quercetin inhibits gastric cancer metastasis PAK1 LIMK1 MMP2 MMP9 PMC5369955__F9 Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway LAMP2 NEU1 CTSL TFEB PMC5675827__F7 Ingenuity Pathway Analysis (IPA) comparisons of the quantified readouts from HTRA2 TRIR HSPD1 RAD17 SRC TNFRSF10A DIABLO FADD PMC7920909__F2 SARS-CoV-2 Replication ALB ACE2 PMC4712384__F2 HCV replication cycle CD81 EPHA2 NPC1L1 EGFR LDLR CLDN1 PMC12240182__F1 Novel AR axis-directed therapy for the treatment of metastatic prostate cancer CYP17A1 CYP11A1 PMC3265067__F7 Phospholipid biosynthetic pathways PSD PEMT PC PCYT2 PMC4712384__F4 Evasion of innate immunity by HCV viral proteins TBK1 STAT1 MAVS TLR3 STAT2 IRF3 SOCS3 TRAF3 EIF2A TYK2 MYD88 PMC8479296__AF1 LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway LIN28B AGO2 PMC8465210__F10 Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity APC GSK3B CCND1 CTNNB1 PMC4672200__F3 Schematic of the proposed non-canonical Wnt signaling pathway induced in the ceca from experimental chickens with persistent colonization by Salmonella Enteritidis CAMK2A CTNNB1 PMC2885424__F7 Transcriptional Regulation of the IGF Signaling Pathway by Amino Acids and Insulin-Like Growth Factors during Myogenesis in Atlantic Salmon MAP4K3 IGF1R MTOR IGFBP6 IRS1 PMC8465210__F15 Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity CRK HGF SRC PMC5120243__F4 Network model for CTNNB1 APC SOX2 GSK3B AXIN1 MYC CTNNB1 PMC6470689__F1 Proposed oncogenic mechanisms for Plk1 SUZ12 GTSE1 REST TOPORS PTEN MDM2 MYC PLK1 PMC5527948__F1 Scheme depicting the major compartments of the endocytic pathway and selected endocytic proteins participating in the transmission of signaling to the nucleus, by affecting the transcription machinery and/or the chromatin‐remodeling factors CITED2 VPS37A SSRP1 ELL BIN1 NUMB SNX1 TSG101 CTNNB1 PMC7471098__F7 Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer PIERCE1 ATF4 TRIB3 KRAS PMC10854812__F5 Function of CD133 protein GRB7 FYN NRAS PTEN MDM2 GRB2 PMC2795248__F3 Anti-inflammatory effects of EPAC in VECs STAT3 SOCS3 RHO PMC5980113__F6 Role of MICAL1 in breast cancer cell proliferation MICAL1 CDK4 CTNNB1 PMC3777479__F2 Niclosamide targets the Wnt/Beta-catenin, Notch, and mTORC1 pathways APC GSK3B IRS1 CTNNB1 PMC7265137__F3 Simplified picture illustrating some examples of how microorganisms promote the cancer TH STAT3 IL1B CTNNB1 PMC4732855__F5 MAPK signaling pathway, determined using the Kyoto Encyclopedia of Genes and Genomes database MAX ECSIT MAFK FAS EGFR DUSP9 CD14 POLI IL1A PLA2G12B DAO FLNA FGFR2 PLA2G10 HEL-S-11 MAP3K6 PMC10854812__F8 Models of both non-receptor tyrosine kinase- (NRTKs) and receptor tyrosine kinase-mediated signaling pathways in tumor progression and drug resistance STAT3 GRB7 FYN BRAF NRAS PTEN MDM2 GRB2 DEPTOR PMC10854812__F9 Downstream effectors of RTK-mediated pathways and their biological consequences GRB7 SGK1 GSK3B BRAF NRAS BCL2 PTEN MDM2 GRB2 DEPTOR PMC9687113__F2 DNA Damage and Repair in Idiopathic Pulmonary Fibrosis XPA MSH6 LIG1 MSH2 PMS2 PCNA MUTYH SSB XPC PMC3876931__F10 Differential regulation of the REGG–proteasome pathway by p53/TGFB signalling and mutant p53 in cancer cells HDAC1 SIN3A PMC11929932__F2 Immunomodulation on tumor immune microenvironment in acquired targeted therapy resistance and implication for immunotherapy resistance CD40 NCOR1 CCR7 MUC4 CD163 CDK4 PMC4685960__F3 Endosomal Toll-like Receptors in Clinically Overt and Silent Autoimmunity STAT1 RO60 TLR7 IL6 TNF PMC7464802__F3 MOMP-induced signaling activation in tumor cells BAX PANX1 CGAS DFNA5 IL1B PMC3332287__F2 Wnt signaling pathway participated in the activation of hepatic stellate cells RBX1 ROCK2 APC LRP5 CER1 SMAD4 LRP6 SKP1 NLK PROC PMC3734089__F1 Macrophages in pancreatic cancer initiation and progression STAT3 ADM SOX9 KRAS PMC11496054__F1 CGAS–STING pathway of cytosolic DNA sensing TBK1 CGAS IRF3 PMC7080988__F2 Computational Model of the Endothelial to Mesenchymal Transition STAT3 GATA2 SNAI2 SMAD1 SMAD2 DLL4 NRP1 SMAD6 NRARP VEGFA FGF2 FLI1 SNAI1 WNT7A ZEB2 LEF1 TWIST1 PMC6452569__F8 Parturition-specific signaling networks constructed using shortest paths and differential expression data BAD PRMT2 OSM PGR SPHK1 SFN MAPK9 MYO1G MYC RARA PNP UBE2D4 PIM3 BATF3 MDM2 EIF4A1 AHNAK SRC MAPK1 NR1i1 CRYZ MT1A DCAF6 PTN PIM1 PLAUR NAMPT COPZ2 HEL-S-34 VHL CD34 CCDC6 HRAS ACACB CEBPA MT2A RELA RXRA CASP3 PRKX EP300 PFN2 NFYC TRAF2 YWHAZ PMC4835676__F5 An integrated model of the TLR signaling pathway modulated by the multifurcating motif of poeModules M14-M18 TBK1 TIRAP TMCC3 ETV3 TAB3 TGIF1 TRAF3 TRAF6 MYD88 ISG20 SLAMF7 STAT1 RIPK2 SP100 BAZ2A RUSC2 OAS2 NFKBIZ STAT2 CRKL IRF3 IRF7 IFNA2 IRF8 TNF VCAN SPRED1 NFKB1 CARHSP1 JAK1 IFNB1 REL DHRS3 EHD1 PMC11496054__F2 CGAS-STING signaling in female reproductive system diseases USP35 HDAC3 TBK1 CGAS TRIM28 SETDB1 IRF3 POLE PMC8065059__F4 Metabolic capabilities among distinct lineages within the Brockarchaeota phylum FTL ACD PMC8506768__F4 Bioinformatic analysis of differentially expressed genes and pathways in idiopathic pulmonary fibrosis CD3D ZAP70 EGF PIK3CA TIRAP LAT PIK3R3 PPP3R1 RPS6KB2 PIK3R1 HIF1A PPP3CA PPP3CC IKBKG MAPK3 MYD88 MAPK14 STAT1 PLCG1 MAP2K6 CSNK2A2 TICAM1 TLR4 NFKBIE BATF3 CHUK MAP2K3 JUN IFNGR1 BATF2 PTPN11 NFATC1 PTPN6 KRAS HRAS PRKCQ RPS6KB1 RELA IKBKB NFKBIA JAK1 NFKBIB CD3E PMC3516830__F2 Interaction loop between the EGFR signaling pathway and miR-221/222 expression in the modulation of cellular processes TRPS1 BAD TIMP3 EGFR PTEN ZEB2 GRB2 MTOR PMC3070952__F1 Essential features of the PERK signaling temporal delay circuit ATF3 ATF4 EIF2A PMC10869077__F9 TNF signaling pathway PIK3CA LTA CSF1 TRAF3 SOCS3 CCL2 MMP3 CYLD CSF2 PGAM5 JUNB DAB2IP IRF1 TNF FOS TRAF1 VCAM1 CCL20 IL15 MMP14 FAS TRADD TNFAIP3 ITCH MLKL NOD2 CHUK RIPK1 ATF4 CEBPB JUN SELE LIF BAG4 VEGFD CXCL2 MMP9 PTGS2 IL6 CXCL6 RIPK3 MAP3K7IP1 NFKB1 IKBKB CASP3 NFKBIA IFNB1 BIRC2 TRAF2 FADD PMC7859322__F2 EMT-related lncRNA in the process of triple-negative breast cancer metastasis MMP7 PTCH1 ZEB2 PMC7743012__F4 Activation of cancer‐related signaling pathways FOXA1 SUFU TLR4 SMAD2 APC GSK3B SMAD4 SMO PTEN MTOR CCND1 CTNNB1 PMC9315613__F3 Phytochemicals as Regulators of Tumor Glycolysis and Hypoxia Signaling Pathways: Evidence from In Vitro Studies PTEN HP MDM2 MTOR PMC2945668__F1 TLR7/9 Signaling pathway leading to the production of proinflammatory cytokines and type I IFN TLR9 IRAK1 IRF7 TLR7 TRAF6 IRAK4 MYD88 PMC4123083__F8 The miR-203-mediated regulation network for skeletal muscle cell proliferation and differentiation MAML1 NOTCH3 MEF2C PMC9543876__F5 Pathway analysis using GRB2, a significantly connected and downregulated protein as the focus ROS1 SHC1 ITCH LAT FRK KIT LRRK1 WAS GAREM1 PTPRE ERBB2 GRB2 GAB2 PMC6296821__F1 Ex vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery IL3RA GRB2 PMC5005393__F1 Demonstration of how gene ontology annotations lead to understanding of biological networks LPL ACADVL ACADL RXRG CPT2 SLC27A4 PMC2042021__F6 Contrasting Infection Strategies in Generalist and Specialist Wasp Parasitoids of Drosophila melanogaster TUB TEP1 DDC TRAF2 MYD88 PMC9688210__F1 Targeting TET2 as a Therapeutic Approach for Angioimmunoblastic T Cell Lymphoma TET2 ICOS FOXO1 ARHA MTOR PMC2958340__F3 Canonical Wnt/Beta-catenin signaling TGFBI NLK CTNNB1 PMC10341274__F2 Contrasting roles of AGRP and POMC neurons in glucose and lipid homeostasis GHSR LEPR POMC ARC AgRP PMC9496564__F2 Co-Stimulatory Receptor Signaling in CAR-T Cells CD80 PLCG1 LAT GSK3B TRAF1 ATF2 TRAF3 GRB2 MTOR TRAF2 LCK PMC4322984__F9 Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/Beta-catenin pathway ABCB1 CTNNB1 PMC6365103__F1 Copper distribution pathways in a generalized mammalian cell ATOX1 CCS STEAP3 ATP7B HEL-S-44 ATP7A PMC2134904__F7 Schematic representation of the effects of RhoA/ROCK signaling pathway inhibition on membrane FasL expression and lymphocytes apoptosis FAS HEL-S-62p ARHA PMC10312929__F8 Wnt signaling pathway BAMBI SOST INVS SIAH1 ROCK2 APC NOTUM SMAD4 RYK NLK PMC12139977__F6 Intersecting network analysis reveals interactions among genes involved in insulin secretion, cell cycle, and ER stress pathways JUND TICRR GADD45G GSG2 MYBL2 CCNA2 SKP2 PLK1 FBXO2 BIRC5 ISL1 ABCC3 CDKN3 CENPF NR2E1 SERINC3 TIMELESS DTL EZH2 TUBB FOXG1 CDCA3 CDC45 MCM2 UHRF1 LMNA HMGA2 CDC20 MC4R CENPE CUZD1 INS XBP1 FOXM1 TUB PRC1 RIMS2 EXOC6 SPAG5 STIL ANKS4B FAM83D TRIP13 RRM2 KNTC2 KIF18B SEC61B ESCO2 SPC25 CEP55 SNAP25 GRB14 HCTP4 PMC7346528__F1 Hedgehog signaling pathway DYRK1A KIF7 PTCH2 SUFU PTCH1 SHH IHH GLI3 PMC3770777__F5 Schematic description of the metabolic network proposed to link DFMO-mediated inhibition of polyamine synthesis to observed perturbations in the methionine cycle, trans-sulfuration pathway, purine synthesis/salvage and de novo thymidine production SHMT1 MTHFS PMC1857308__F9 The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones PMP22 MTOR PMC9456457__F1 Insulin Receptor Substrate Proteins in Bronchopulmonary Dysplasia and Asthma: New Potential Perspectives PTEN GRB2 MTOR PMC3366885__F1 Signaling pathways involved in head and neck cancer TF ERBB3 STAT3 BAD SP1 EGFR ERBB2 GRB2 MYC SET PMC5433721__F6 An integrative analysis of tissue-specific transcriptomic and metabolomic responses to short-term dietary methionine restriction in mice SDHA UQCR11 UQCRFS1 NDUFB9 UQCRC2 ZNF183 UCP1 NDUFAB1 COX17 NDUFA10 PMC5518133__F2 Regulatory mechanisms of WBP2 in breast cancer WBP2 EGFR CCND1 CTNNB1 PMC7824603__F1 An integrated model of the molecular pathway underlying light-mediated seed germination PIF1 DAG1 PMC5884799__F7 MS TLR signalling pathway POR CD40 STAT3 IFNA14 SERPING1 RELA ELL CS IL6 CCL2 TNF IL1B PMC5884799__F8 Multiple sclerosis pathway IFNG EGR1 PTPRO CTSL LDLR NCOA7 PMC3893124__F1 Current and Future Therapies for Hepatitis C Virus Infection CD81 SCARB1 EGFR LDLR PMC11313706__F6 Regulatory mechanism of bone injuries induced by fluoride COL1A1 FGFR1 BMP2 BCL2 BMP7 MMP9 PMC5915419__F1 Molecular association of Wnt, MITF, TYR, and DCT GSK3B DCT CTNNB1 PMC3492208__F3 Principal IFN-Alpha-modulated canonical pathway in MT-4 cells IFNG BAX STAT1 STAT2 PSMB8 IRF9 PIAS1 IRF1 GIP IFI35 PMC5743859__F4 Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders STAT3 IRF7 NOD1 TRAF3 PMC1994616__F1 New molecularly targeted therapies for lung cancer HRAS EGF EGFR BRAF PTEN PMC9846474__F6 Unraveling the links between neurodegeneration and Epstein-Barr virus-mediated cell cycle dysregulation ATR CDK6 AURKB ATM MDM2 CDK4 PMC1994616__F2 New molecularly targeted therapies for lung cancer APC SMO ADAM10 PMC5362636__F2 Possible interplay between insulin-like growth factor (IGF)-1 and vascular endothelial growth factor (VEGF) receptor signaling pathways IGF1 BMP2 RUNX2 CTNNB1 CD34 PMC7020744__F14 Role of RKI-1447 in liver cells and the TLR4/TBK1/IRF3 signaling pathway TBK1 ROCK2 TLR4 ROCK1 IRF3 ARHA PMC3845098__F1 N-glycoprotein biosynthesis in mammals ALG5 ALG8 DPM2 ALG6 ALG10 DPM1 ALG13 ALG1 ALG3 DPAGT1 DPM3 PMC3824607__F3 Crosstalk in TNFR1 signaling TRADD GADD45B TRAF2 FADD PMC3824607__F1 TNFAlpha-mediated transient IKK activation pathways MAP3K7IP1 TRADD TRAF2 PMC1904333__F2 Hepcidin regulation: ironing out the details STAT3 TFR2 SMAD4 HAMP HFE HFE2 PMC5029683__F8 cRGD inhibits vasculogenic mimicry formation by down-regulating uPA expression and reducing EMT in ovarian cancer CDH2 MMP2 HEL-S-28 MTOR PMC8844459__F1 Application of Animal Models in Interpreting Dry Eye Disease TNF PMC12133868__F2 MAPK signaling pathway TSC2 BAD BRAF MTOR RET PMC8968959__F1 Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration EGF CBL GRB2 PMC12133868__F3 Application and recent advances in conventional biomarkers for the prognosis of papillary thyroid carcinoma BRAF TERT MYC FOS PMC2764635__F3 New model of EGF activated ERK pathway: This is a schematic of our new model of the EGF activated ERK pathway which was developed from the original EGF model EGF RAF1 EGFR PMC6361568__F7 Cullin‐3 (CUL3) and KCTD10 regulate cell proliferation in SKBR‐3 cells EGF EGFR RHOB KCTD10 RAC1 PMC7182067__F1 The Regulation of Coagulation and Thrombosis TF VWF TRPM7 TIEG2 HMGB1 RALB RALA ADAMTS13 PMC2764635__F1 The EGF activated ERK pathway: This is a schematic of the EGF activated ERK pathway beginning at the level of EGF binding to EGFR and finishing at the level of ERK; see the text for more details on the features and functions of the pathway CRK EGF RAF1 EGFR GRB2 PMC6909948__F4 cAMP can regulate multidrug-resistance in lung cancer through the regulation of plenty of downstream effectors, which is participating in the cAMP signaling pathway such as the classical PKA and CREB or some other useful effectors GSK3B ATM CFTR CTNNB1 SIRT6 PMC3681194__F1 Genes with mutations that cause monogenic, severe T-cell immunodeficiency in humans can be intrinsic to the thymic epithelium or to T cells DNMT3B ZAP70 TAPBP RFX5 RFXANK JAK3 RFXAP RAG2 SP110 CBL ATM TAP2 ADA PMC2764635__F7 Experimental results of Rap1 pathway knockout from Falco et al FRS2 GRB2 RET PMC2764635__F8 Comparison of growth factor receptor signalling: This figure shows a comparison of ERK signalling from the EGF and Insulin receptors CRK EGF RAF1 EGFR MAL GRB2 PMC4782155__F3 miR-146a-5p and miR-155-5p mechanism of action under normal conditions and early stages of inflammation (, , ) TLR4 IRAK1 TRAF6 PMC4367534__F2 Regulators of HR repair as potential therapeutic targets CDC2 RBMX ATR RAD51 EGFR BRCA2 IGF1R PLK1 BLM IRS1 PLK3 BRCA1 ATM CDC5L PMC6131304__F3 PCV2-induced apoptosis FAS ATF4 ATF2 EIF2A PMC4367534__F1 DNA double strand break (DSBs) repair RAD50 RAD51 MRE11A DNA2 BRCA1 BRCA2 BLM RPA1 PMC8346253__F1 Distinct Signaling Pathways Distinguish in vivo From in vitro Growth in Murine Ovarian Follicle Activation and Maturation PTEN MTOR PMC7773602__F1 Autophagy and endolysosomal trafficking at the synapse APP RAB35 RAB26 PMC2133163__F6 Anchorage-dependent cell growth CRK JUN FOS PMC3643575__F4 Arachidonic acid metabolism pathway where the differential genes and metabolites of colorectal cancer were annotated PGC DIO1 LOX LIF ACD PMC321455__F9 A model depicting the relationship between the p19Arf-p53 tumor suppressor pathway and the Rho GTPase signaling module in the regulation of cell proliferation and transformation CDC42 PI3 ARHA RAC1 PMC3561661__F1 Activation and function of PI3K/Akt signaling in CD8 T cell RHEB TSC2 KLF2 TSC1 APC IL7R PTEN MYC LEF1 CTNNB1 PMC7093717__F8 Schematic diagram depicting how luteolin inhibits airway allergic responses JAK3 JAK1 GATA3 PMC7044323__F8 Gene expression profiles of p53 signaling pathway (hsa04115) in the bryostatin treated CD4+ T cells TP73 ATR IGF1 PERP ATM RPRM PTEN MYC PMC8826420__F7 Proposed molecular mechanisms of ANGPTL7 in CLAN formation in TM cells SP1 ANGPTL7 ARHA PMC6376273__F2 The pathogen‐derived molecules employed to evade the intracellular DNA sensing pathway TBK1 CGAS AIM2 IFI16 IRF3 PMC9166676__F4 Chemoresistance in cancer stem cells CDC42 BAX DKK3 ALDH2 ABCC1 BMP1 ABCG2 CTNNB1 PMC4741068__F2 Reconstruction of the insulin/insulin-like growth factor 1 (IGF1)-like signalling (IIS) pathway of Haemonchus contortus PMC5744163__F1 Three types of autophagy and regulatory mechanisms ATG3 ATG12 ULK1 UVRAG AMBRA1 ATG14 BCL2 MTOR ATG5 PMC8071872__F5 Lack of Cell Cycle Inhibitor p21 and Low CD4+ T Cell Suppression in Newborns After Exposure to IFNB STAT1 STAT2 IRF9 PMC11211608__F2 Understanding copy number variations through their genes: a molecular view on 16p11.2 deletion and duplication syndromes KCTD13 TAOK2 MVP ARHA PMC9550700__F7 Contribution of the Immune Response in the Ileum to the Development of Diarrhoea caused by Helminth Infection: Studies with the Sheep Model STAT3 TH TGFB1 IL21R TBX21 RORA IL-21 IFNG NOD2 IL18 OMA1 FOXP3 IL18RAP IL1B IL10 IFNGR1 IL18R1 APC IL1A IL6 TNF GATA3 tal-1 IL24 IL23R PMC9550700__F8 Contribution of the Immune Response in the Ileum to the Development of Diarrhoea caused by Helminth Infection: Studies with the Sheep Model OSM RELT TNLG2B PMC12108277__F5 Summary schematic diagram of the mechanism by which miR-129a-3p negatively regulates the inflammatory response to G TLR4 MYD88 PMC8998186__F3 Recycling and Reshaping—E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response ZAP70 FYN ITCH USP12 OTUD7B USP9X CYLD LCK PMC8998186__F4 Recycling and Reshaping—E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response USP15 BCL10 ITCH USP12 JUNB MDM2 USP9X TRAF6 PELI1 PMC6315101__F1 Central metabolism in the S SART3 CS MDH2 PMC8490443__F4 BMP7 reduces the fibrocartilage chondrocyte phenotype S100A4 MMP14 ALPL COL1A1 PLG CEMIP MMP2 BMP7 TMEM119 PMC6065472__F7 Enriched pathways for radix tetrastigma hemsleyani flavonoid treated lung cancer cells MAX EGF JUND BAD FAS NRG3 MTOR MYC FLNA MEF2C NRG4 NF1 BTC SRC ECSIT CD14 TNF SHE FOS NRG2 CRK NRG1 HBEGF CBL MAP3K7IP1 MOS NLK GRB2 BDNF TRAF2 PMC8800342__F1 Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress JUN BAD MYC PMC5494993__F6 Discovery of extremely halophilic, methyl-reducing euryarchaea provides insights into the evolutionary origin of methanogenesis POR CD2 CYB RPIA FER ADK FES PROC PMC2575803__F1 Most prominently involved biological pathways in OSCC STAT1 CRAT PIM1 STAT2 PIAS1 MTOR TYK2 PMC10971338__F1 General schemes of the NAD+ metabolic pathway NRK NAPRT HEL-S-90n NAMPT PMC4379025__F12 Telomerase Inhibition Decreases Alpha-Fetoprotein Expression and Secretion by Hepatocellular Carcinoma Cell Lines: In Vitro and In Vivo Study STAT3 AFP MTOR PMC8348973__F2 Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease? TLR5 TNF PMC7643645__F6 Potential working model for the suppression of Asperolide A in bone metastatic breast cancer CTSK NFATC1 MTOR PMC7393488__F7 LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-кB signaling pathway RNF121 LEF1 IRAK4 MYD88 PMC9311450__F1 Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches BAX BAD IGF1 PMC3922885__F7 RhoC Regulates Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma by Overexpressing IL-6 and Phosphorylation of STAT3 STAT3 PMC4739416__F1 JAK-STAT signaling contributes to the pathogenesis of MPNs EPO TPO MTOR PMC10963420__F1 Mechanism of astrocyte regulation of Lcn-2 NGFR NFKBIA LCN2 EIF2A NOX4 PMC8507001__F6 Baicalin promotes chondrocyte viability and the synthesis of extracellular matrix through TGFB/Smad3 pathway in chondrocytes SOX9 ADAMTS5 PMC11881707__F3 Interaction mechanism between intestinal flora and cAMP-PKA signaling pathway in neurological diseases CORT TPH1 CRH PMC3876023__F1 Suppression of regulatory B cells identified in human and animal CD40 CD80 IL10 BCR FOXP3 PMC2684867__F1 VHL Loss of Function and Its Impact on Oncogenic Signaling Networks in Clear Cell Renal Cell Carcinoma HGF LRP5 LRP6 PMC4149909__F2 Gaps in conventional treatment of heart failure include deranged Beta-AR signaling, distorted Ca2+ cycling with depletion of SR Ca2+ levels, diastolic dysfunction, and cell death ADRBK1 RYR2 PLN BAD CAD PMC4944499__F7 CRT-knockdown correlates with the modulation of p53 and MAPK pathways SERPINB5 MAP2K6 ATM MDM2 MAPK8 PMC10493031__F3 Schematic illustration of the CRC-derived exosome mechanisms for CRC metastasis CD81 HGF SMAD2 CXCL16 SMAD4 ARHA CD44 ADAM17 BTG2 CD9 SRC CXCR4 CD63 PMC10493031__F5 Schematic illustration of key molecular signaling pathways in metastasis TET2 PNMA5 TGM6 HGF L1CAM EGFR HOXC13 KRAS CTNNB1 CD44 FBXW7 MACC1 NTF4 IGF1 MUC1 REG1B CXCR4 ZFP57 PMC11247318__F1 Action in lymphoma IFNG SYK BTK CD19 LYN TNF PMC12082737__F3 Canonical wnt signalling pathway (Kharaishvili et al APC WIF1 CTNNB1 PMC2976306__F7 Changes in gene expression in central carbon metabolism (A) and ergosterol synthesis (B) HEL60 GPD2 PES1 ENO2 HEL-S-68p GLG1 ENO1 MDH2 ERG HEL-S-26 GPD1 PMC6605468__F5 Schematic model of morphogenic gradients controlling striatal development and involved in abnormal neurogenesis in Rarb−/− mice RARA DRD1 RARB ASCL1 MEIS1 FGF5C PMC10930964__F1 Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets MLST8 RICTOR DEPTOR PMC6887951__F4 FGFR pathway and dysregulation in cancer FRS2 GRB2 PMC5760356__F1 Kegg PI3K/Akt‐Signaling pathway with highlighted dysregulated mRNA and their associated seed‐region matched miRNA MIA SYK BAD GNE BCR EBP CHL1 RBL2 PTEN MTOR RAC1 PMC5102338__F6 Diagrammatic representation of possible mechanistic pathway for the induction of EGID TGFA PMC8502875__F5 Soluble Epoxide Hydrolase Inhibitors Regulate Ischemic Arrhythmia by Targeting MicroRNA-1 PI3 GSK3B PMC7567953__F1 Sphingosine-1-phosphate (S1P) production and S1P/S1PR signaling pathways S1PR1 SPNS2 S1PR3 SPHK2 S1PR2 SPHK1 RHO S1PR5 S1PR4 PMC7567953__F2 Dental regenerative therapy targeting sphingosine-1-phosphate (S1P) signaling pathway in endodontics S1PR1 SMAD1 DKFZp781O1323 HEL-S-62p S1PR2 SMAD4 ARHA RUNX2 CTNNB1 PMC7882108__F8 VD3 ameliorated NM‐induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3–SOD2–mtROS signaling pathway SIRT3 NLRP3 IL16 PMC7567953__F3 Dental regenerative therapy targeting sphingosine-1-phosphate (S1P) signaling pathway in endodontics S1PR2 GSK3B LRP5 CTNNB1 PMC5661282__F9 Role of glycolysis in NPC self-renewal IGF1 CITED1 FGF9 SIX2 BMP7 IGF2 PMC7688453__F1 ERK and AKT pathway on lymphangiogenesis PROX1 TSC2 VEGFC TSC1 NF1 ATF1 PTEN GRB2 VEGFA MYC RASA4 PMC12095467__F8 125I particles inhibit the progression of cervical cancer by up-regulating the HSF1/PU BRD4 SYK HSF1 ATF4 XBP1 SPI1 PMC9691885__F2 Determinants regulating Toxoplasma gondii bradyzoite development HDAC3 IFNG PMC9691885__F1 Determinants regulating Toxoplasma gondii bradyzoite development ENO2 CST1 ENO1 PMC7649967__F2 Biglycan in the Skeleton SMAD1 SOST SMURF1 DKK1 BMP2 LRP5 OSCAR LRP6 NFATC1 SMURF2 RUNX2 CALCR PMC7662933__F3 ErbB receptors and their signaling pathways ERBB3 NRG2 NRG1 FYN ERBB4 NRG3 ERBB2 GRB2 MTOR SRC NRG4 PMC9560885__F2 Race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options CDK6 EGFR CCND1 CDK4 PMC133602__F6 The yeast glyoxylate bypass pathway and its possible connection with other predicted changes HEL60 COX5A HEL-S-32 HEL-S-26 PMC7169117__F6 Schematic illustration of the major KSHV factors and corresponding targets, by which KSHV modulates the TGF‐B signaling pathway THBS1 DKFZp781O1323 SMAD2 PMC8826489__F1 Circadian rhythms of 11-oxygenated C19 steroids and Δ5-steroid sulfates in healthy men HSD3B2 CYP17A1 CYP11A1 HSD11B2 SULT2A1 HSD11B1 PMC7169117__F7 Schematic illustration of the major HTLV‐1 proteins and corresponding targets, by which HTLV‐1 modulates the TGF‐B signaling pathway FOXP3 HBZ PMC7169117__F8 Schematic illustration of the major SARS‐CoV proteins and corresponding targets, by which the virus modulates the TGF‐B signaling pathway STAT3 EGR1 PMC3122057__F8 Proposed schematic of the roles of NIK and SMG1 in sensitive versus resistant cells in response to SMC and TNFA treatment SMG1 TNF TRAF2 FADD PMC7169117__F2 Schematic illustration of the major HCV proteins and corresponding targets, by which HCV modulates the TGF‐B signaling pathway PTEN SMURF2 PMC6526582__F1 Schematic representation of the three candidate genes and the four tag SNPs selected for this study in the IL-23 signalling pathway (SNPs rs3212227 and rs6887695 in IL-12B, SNP rs7857730 in JAK2, and SNP rs2293152 in STAT3) STAT3 TYK2 IL12RB1 PMC5607814__F1 AMIGO3 and LINGO-1 signaling in neurons.Both AMIGO3 and LINGO-1 are able to form a complex with NgR1 and P75/TROY (Mi et al., 2004; Ahmed et al., 2013) LINGO1 RHO PMC7169117__F4 Schematic illustration of the major HPV proteins and corresponding targets, by which HPV modulates the TGF‐B signaling pathway SP1 SMAD2 SMAD4 PMC5607814__F2 Mechanisms of action for LINGO-1 and speculative AMIGO3 signaling in oligodendroglia.(A) LINGO-1 is able to bind to ErbB2 and prevent its translocation to the lipid rafts on oligodendroglial membranes EGFR ERBB2 LINGO1 MTOR PMC7169117__F5 Schematic illustration of the major EBV proteins and corresponding targets, by which EBV modulates the TGF‐B signaling pathway ATF3 SMAD4 PTPRK ID1 PMC6015663__F4 SHP2 plays a key role in NSC proliferation, differentiation, and migration STAT3 EGF GRB2 CXCR4 PMC8744084__F2 Molecular regulation of brain metabolism underlying circadian epilepsy DBP PER2 CRY1 NAMPT MTOR RORB NFIL3 RORA TSC2 TSC1 CRY2 HLF SIRT1 TEF PMC3461607__F1 LPS/TLR-4 signaling pathway.Notes: LPS is delivered to CD14 by LBP, which in turn transfers LPS to TLR-4 TLR1 CD14 TLR5 LBP IL1B MYD88 PMC11792562__F4 Pathway map of differentially expressed genes involved in cytidine synthesis across the comparison groups: A glycolytic pathway; B TCA cycle; C cytidine synthesis pathways SDHA SDHB SDHC PMC11792562__F5 Pathway diagrams of differential metabolites related to the cytidine synthesis pathway in the comparison groups: A glycolytic pathway; B TCA cycle; C cytidine synthesis pathways SDHD SDHA SDHB SDHC PMC3434281__F6 Proposed model for attenuation of canonical TGFB SMAD and activation of non-canonical TGF-Beta-NFKB signaling pathways in HNSCC TGFB1 SMAD2 SMAD4 PMC8199989__F2 HECT-Type E3 Ligase in the Development of Cardiac Disease BIRC5 ITCH TXNIP GSK3B LRP5 LRP6 ATP2A2 CTNNB1 SIRT6 PMC8527165__F2 Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward CA3 AHR LAT2 PMC8527165__F3 Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward AHR PMC8527165__F1 Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward MAPDA PNMT DBH KIN THRA MPO PMC6016890__F3 Mechanisms behind low levels of hepcidin in liver disease TFR2 HAMP HFE PMC9268799__F5 Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway PTPN1 PPP2CA TERT CCNA2 MAPK8 CDK5R1 BCL2L1 CDK5 PRKCA MAPK10 MAP2K1 JAK1 SRC CCND1 LCK PMC11592827__F13 Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study SYK EIF4B BAD RBL2 PTEN CD19 MTOR RAC1 EIF4E RHEB TSC2 TSC1 BCR CD37 MDM2 PMC9247875__F6 Prediction of Angiopoietin-like Protein 4-related Signaling Pathways in Cholangiocarcinoma Cells RPL5 ANGPTL4 PRKDC RPL21 MTOR PMC9268799__F2 Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway CDC2 PTPN1 CTSS PPP2CA TERT CCNA2 MAPK8 BCL2L1 CDK6 CDK5 PRKCA CDK2 MAPK10 MAP2K1 SRC CCND1 EPHX2 LCK CDK4 PMC11592827__F14 Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study LPL UBC AQP7 CYP7A1 UCP1 HEL-S-28 PLTP CPT2 PMC11730944__F5 Upregulated and downregulated gene expression profiles within distinct pathways LTB CXCL13 INHA TIRAP CCL21 EPOR LIF LEPR XCL2 NODAL AMH CXCR4 PMC12021630__F10 Molecular mechanisms of PGRN in diabetic nephropathy ULK1 HK2 PMC2806747__F1 TLR4 signaling pathway can be activated via GAG fragments requiring CD44 and MyD88 or through LPS, which requires MyD88, LBP, and CD14 CD44 CD14 LBP IL1B MYD88 PMC4391134__F7 Diagram of potential APOE4 -induced decrease in synapse-related proteins and disruption of NMDAR-mediated signaling, resulting in impaired learning and memory FIG4 FIGN APOE APOB FLG BDNF PMC6630988__F2 Herpesviruses modulate the JAK-STAT pathway IFNGR2 IFNGR1 IFNLR1 STAT2 IFNAR2 IRF9 IFNAR1 IRF1 JAK1 TYK2 PMC8741861__F7 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells ADRBK1 RPS6 FSHR PMC8741861__F8 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells RHEB RPS6 FOXO1 GSK3B PTEN MTOR FSHR PMC8741861__F5 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells RPS6 EGFR FSHR CDK4 PMC7369546__F3 ClueGO plug-in, in terms of biological process and biochemical pathway process annotations, revealed biological terms which were associated with the 7 hub-bottlenecks (see ) CXCL1 IL6 MMP9 PMC4933276__F10 The proposed T835M-UNC5C- and V642I-APP-induced neuronal death-signaling pathways CDC42 STAT3 CNTFR SH3BP5 APP RAC1 PMC8040300__F7 Molecular mechanisms underly GSS against brain injury in tMCAO rats CD40 HEL-S-64p CD68 IL1B PMC7463618__F3 Lipids in regulating NLRP3 inflammasome UCP2 NLRP3 CD36 TLR4 FASN CPT1A NOX4 PMC7409684__F1 Pathological roles of ion channels and transporters in triple-negative breast cancer cells AQP3 CFTR MCU IGF1R AQP1 PMC8660813__F9 Kinetin-induced death of Vicia faba ssp. minor root cortex cells KIN PMC5912903__F1 PRPP riboswitches and their regulatory network PURA GC GCA UACA PURB PMC6020658__F3 Pathway mechanisms underlying CHMs improve lipid metabolism in liver cells PCSK9 FAS NR1C1 ABCG5 LDLR HLF PMC3077584__F6 The effects of apoA-I on TNFA mRNA stabilization in LPS-stimulated macrophages STAT3 TLR4 IL1B PMC11313175__F2 RNA methylation in the development of muscle and fat in livestock STAT3 TG EBP GADD45B JAK1 MEF2C PMC10494518__F1 Insulin signaling pathway CRK CBL GRB2 MTOR IRS1 PMC7169117__F1 TGF‐B signaling pathway TF SMAD2 SMAD4 TGFBR1 PMC7520422__F9 Sphingosine-1-phosphate (S1P) acts in both S1PR dependent and independent pathways SPHK2 SPHK1 RIPK1 TRAF2 PMC4183579__F3 Role of MicroRNA Modulation in the InterferonA/Ribavirin Suppression of HIV-1 In Vivo MOV10 RFC1 STAT2 PERP PIK3C2A PML RSAD2 S100A2 GBP1 DDB2 CHEK2 UBAP2L UNG MCM6 ISG15 EIF2AK2 PMC5824490__F6 Emerging Roles for SIRT5 in Metabolism and Cancer HEL-75 IMPACT HEL-S-44 PMC3175712__F1 (A–C) Schematics of Wnt signaling components in the absence of a Wnt signal (A), the presence of a Wnt signal (B), and the presence of a Wnt signal blocked by the displacement of Tcf7l2 by dnTcf7l2 (C) GSK3A APC GSK3B CTNNB1 PMC8897435__F8 Model of this study CTHRC1 CCND1 PMC8227515__F1 Emerging Role of Amino Acids of the Brain Microenvironment in the Process of Metastasis Formation PHGDH SHMT1 HEL-S-51e PMC3218904__F1 Network pathway analysis of up-regulated genes in the gene category immune response KCNC3 TAPBP SBNO2 PARP4 CES2 DNAJC14 SLC16A6 XPNPEP2 HERC3 ENTPD1 PTPN6 CLEC4E MDFI ANXA11 CBFA2T3 NR2A1 HLA-E HLA-F LILRA2 DGKD ATN1 CXCR4 PMC4718447__F1 Translational metabolomics in cancer research TLK1 HEL-S-133P HK2 FASN CA9 CPT1A PMC3218904__F2 Network pathway analysis of down-regulated genes in the gene category mitotic cell cycle HEL164 AURKA RAN UBE2C NCAPG NEK2 MYC SH3BGRL2 YY2 ZNF175 SMC2 SMC4 CENPF MSH6 CETN3 ESPL1 MSH2 CES2 POLE2 PRIM2 SMC1A DUT NEK1 POLA1 RAB1 GINS2 CDC27 CDC25B PCNA INA BRCA2 CDC23 MAP2 KPNA2 GTSE1 TTK ACHE SBNO2 CLPB DKFZp667O1614 RRM2 KNTC2 TRUB2 FAM117A NEK4 GMNN NR2A1 PPP2R1B INCENP BCAT1 HCTP4 PMC3775856__F10 Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation CAST TFPI PLG PMC3026473__F2 Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets BNIP3 IRS1 PMC7369546__F4 ClueGO plug-in, in terms of biological process and biochemical pathway process annotations, revealed biological terms which were associated with the 7 hub-bottlenecks (see ) IL10 CXCL1 CXCL2 IL6 MMP9 TNF PMC9561999__F6 Good, the Bad and the New about Uric Acid in Cancer RHEB TSC2 TSC1 MTOR PMC3715494__F2 A Lover and a Fighter: The Genome Sequence of an Entomopathogenic Nematode Heterorhabditis bacteriophora DDI1 IGF1 SGK1 PMC9561999__F4 Good, the Bad and the New about Uric Acid in Cancer TSC2 FAS HMGCR PMC8396560__F1 Macrophage Motility in Wound Healing Is Regulated by HIF-1A via S1P Signaling IL10 NLRP3 SPHK1 CCR2 IL6 ARHA MTOR CCL2 RAC1 PMC2697061__F2 Endoplasmic reticulum stress in disorders of myelinating cells ATF4 EIF2A XBP1 PMC9074313__F5 Functional roles of the circRNA/Wnt axis in cancer ITCH DKK1 CTNNB1 PMC9074313__F3 Functional roles of the circRNA/Wnt axis in cancer FRZB DKK2 CTNNB1 PMC5448626__F7 Possible schematic model of SNIPER(TACC3)‐induced death in cancer cells TACC3 APC XBP1 PMC9074313__F1 Functional roles of the circRNA/Wnt axis in cancer APC GSK3B RHO DAAM1 CTNNB1 PMC3166778__F1 PI3K signalling pathway: The phosphatidylinositol 3-kinase (PI3K) signalling pathway begins with PI3K activation by receptor tyrosine kinases after growth factors or insulin stimulation BAX TSC2 BAD PTEN MDM2 PMC6477733__F3 Transcriptional reprogramming of the H-series strains H14, 20, 27, and 31 at 24 h post-induction of gene expression tal-1 TACC1 ADH6 FAT1 HIST1H1E POT1 PMC8803618__F3 Microbiota in Gastrointestinal Cancer and Cancer Treatment: Chance or Curse? STAT3 TGFB1 CXCL1 PTGER4 HP CTNNB1 PMC8946661__F8A Systematic Review to Define the Multi-Faceted Role of Lysine Methyltransferase SETD7 in Cancer YY2 CTNND1 CCNA2 RUNX2 GPR49 CCND1 AXIN2 SETD7 TRIM21 PMC4314529__F1 Mechanism of ICL repair in the FA pathway on collision of a replication fork with an ICL BRCA1 USP1 FAN1 SLX4 PMC5599801__F1 Modulating NAD + metabolism, from bench to bedside NNMT NRK NAPRT HEL-S-90n PARP1 PMC11084201__F18 Mechanisms of MPs’ impacts on the liver TG FAS LEP IMPACT PMC3034644__F2 Self-regulation in Xenopus dorsal-ventral patterning.The pathway consists of a network of BMP-interacting proteins BMP4 BMP2 BMP7 PMC4795052__F4 Dysregulation of mTOR signaling pathway and mTOR in sleep phenotype of del 2q23.1 and SMS RHEB TSC2 EIF4B RICTOR TSC1 SMS RHO MTOR ELF3 EIF4E PMC3134268__F1 Schematic representation of the influence of photoperiod on deiodinase enzyme gene expression in the hypothalamus TSHB TSHR PMC5923376__F2 Hippo signaling pathway LATS1 LATS2 YOD1 NEDD4 SIAH2 ITCH AMOT USP9X PMC6828744__F1 Long noncoding RNA: TRIMming the viral load CGAS MAVS TANK TLR9 AIM2 IRF3 IFI16 IRF7 TRAF3 TRIM25 TLR3 TLR8 TLR7 PMC9003189__F2 Amino Acid-Related Metabolic Signature in Obese Children and Adolescents RHEB TSC2 TSC1 DEPTOR PMC8168947__F2 Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target SUFU APC SMO MYC PLK1 CTNNB1 PMC4007928__F1 Key features of the phosphoinositide 3-kinase (PI3K) signaling pathway RHEB TSC2 BAD TSC1 PTEN MDM2 PMC8247573__F1 Arbuscular Mycorrhiza-Mediated Regulation of Polyamines and Aquaporins During Abiotic Stress: Deep Insights on the Recondite Players MYB DAO PMC7814318__F1 Wnt pathway CDC42 APC ARHA CTNNB1 PMC3725758__F2 Neurofibromatosis Type 2 Protein, NF2: An uncoventional cell cycle regulator CDC42 NF2 MTOR CCND1 RAC1 FOS EIF4E PMC8310495__F1 Genetic Determinants of Paget’s Disease of Bone DCSTAMP PFN1 NUP205 PML STMP1 TRAF6 ZNF687 OPTN CYLD PMC8778376__F1 Microenvironmental Metabolites in the Intestine: Messengers between Health and Disease APC D2HGDH AHR ASNS CTNNB1 PMC9623991__F2 Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer LPL CDC42 TNC PLD2 RAB31 EGFR ARF6 FLOT1 FLOT2 RAC1 SPHK2 F2 SAFB PLEKHG2 SRC HNRNPK PMC6156150__F7 Proposed network for AhR-Src-STAT3-IL-10 signaling pathway in inflammatory macrophages STAT3 TLR4 CD14 AHR SRC MYD88 PMC9119763__F7 Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway MFN1 MFN2 PMC9623991__F6 Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer GRM3 SNAP23 STAT3 PANX1 SYT7 HNRNPH1 ORAI1 STIM1 TRPC5 PMC2789271__F1 Gene selection in the TGFß signaling pathway TF TGFBR2 SMAD1 TGFB1 DKFZp781O1323 SMAD2 SMAD6 TGFBR3 SMAD4 TGFBR1 PMC4727338__F2 Interaction between neurotrophins and VEGF NGF MTOR BDNF PMC3732412__F3 KEGG pathway map for genes in the three modules LTBP1 IFNG RBX1 THBS1 FST SMAD6 SMAD4 SKP1 NODAL ARHA PITX2 TGFBR1 PMC3245719__F1 Bioenergetic regulation of cellular physiology and gene expression MCAT BAX PI3 PTEN GPX1 SIRT1 PMC6674889__F9 The promotion of neuronal development by CD47 CDC42 VAV2 SRC CD47 PMC7022772__F6 KEGG proteasome pathway shows involvement of downregulated cytoplasmic IFNG RPN2 RP2 RPN1 ARC POMP PMC6883840__F1 The pathway for synthesis of PLP in E SP1 SP3 SP2 NR1A2 HEL-S-1a PMC3119520__F7 Predicted d-galactose network in Y. pestis SPR PMC12108420__F12 GnRH signaling pathway involves multiple molecular interactions regulating gonadotropin gene expression and secretion CDC42 EGF JUN RAF1 GNRHR EGFR GC MMP2 GRB2 SRC PMC8265195__F3 Drug-drug-gene Interactions as Mediators of Adverse Drug Reactions to Diclofenac and Statins: A Case Report and Literature Review HEL-S-22 SLC22A6 SLC22A7 CYP2C18 CYP2C19 HEL-S-5 SLC22A11 ABCC3 CYP2C9 CYP2C8 ABCG2 CYP3A4 ABCC2 PMC3025764__F4 Metabolic regulation by FOXO1 in skeletal muscle LPL TSC2 PDK4 TSC1 CD36 RXRA MTOR PMC9649783__F7 MYBPC3 deficiency up-regulated NFKB/TGFB1/HIF-1A/aerobic glycolysis signaling cascade in cardiac fibroblasts, contributing to HCM myocardial fibrosis COL1A1 CCL2 MYBPC3 IL1B PMC3910345__F3 Molecular regulation of hepcidin by iron and inflammation STAT3 BMP6 SMAD1 TFR2 DKFZp781O1323 SMAD4 HFE IL6 IL6R HFE2 PMC8161522__F3 Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models TF TH ENG REN DYRK1A TK1 GSK3B NPY NPAS4 ARHA PMC3893930__F2 Ewing’s Sarcoma: Overcoming the Therapeutic Plateau RHEB TSC2 RICTOR FLI1 TSC1 IGF1 IGF1R GRB2 MTOR PMC11914587__F7 Autophagy in neuronal death TBK1 WDR41 SMCR8 SQSTM1 OPTN C9orf72 PMC11914587__F3 Interactome of the molecular systems architecture of the NMJ microenvironment involved in ALS pathogenesis FUS UBQLN2 SEMA3A SARM1 RHO C9orf72 PMC4581211__F8 Proposed model of role of RNase L in crosstalk between autophagy and apoptosis BAX RNASEL BCL2 OAS1 PMC6814203__F2 STING pathway activation initiates the anti-tumor immune response CXCL9 BATF3 CXCL10 PMC6814203__F1 STING pathway signaling and regulation TRIM14 TBK1 TRIM38 CGAS TRIM32 TRIM56 ZDHHC1 STIM1 ULK1 IFIT3 TRIM41 TRAF3 ENPP1 RNF26 TTLL6 INSIG1 TTLL4 GSDMD AMFR SENP2 HMGB1 RNF5 AIM2 IFI16 IRF3 TFAM ATG9A MUL1 TRIM29 TREX1 HMGB2 PMC8470786__F2 Interaction between microRNAs and the Wnt/Beta-Catenin Signaling Pathway in Osteoarthritis SOX9 APC GSK3B FOXC1 NLK CTNNB1 PMC10372241__F1 New insights into regulatory cell death and acute pancreatitis BAX FAS MCL1 APAF1 FADD PMC12189910__F8 Schematic figure depicting the potential role of LPS on endometrial receptivity in sheep TLR4 LIF ITGB3 ITGB5 PMC8534127__F5 Novel Molecular Mechanism of Lenalidomide in Myeloid Malignancies Independent of Deletion of Chromosome 5q GPR68 DDB1 CAST IKZF1 CUL4A IL2RA IRF4 RCAN1 CRBN IKZF3 PMC6592288__F5 Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications RHEB NF1 PTEN CDK4 PMC5423480__F3 Induction of an innate immune response to Ad-based vectors STAT1 TLR1 STAT2 TLR4 IRF9 TLR9 NOD2 MYD88 PMC6221654__F5 Gene regulation network of 4 gene signature models GATA2 MYB SLC40A1 TIMP1 NFATC2 THBS2 TCF2 TCF4 YY1 OTOF STAT1 LIMCH1 COL1A1 NF1 RARB PAX5 ETV4 FOXP3 TBP CEBPB HOXD9 JUN ETS2 NFATC1 INTS8 NR3C1 CKAP4 CEBPA ITGAM RXRA EDNRB STAT4 VCAM1 PMC4067122__F6 Schematic drawing of the Hippo pathway in human EC LATS2 CCND1 YAP1 PMC5070033__F1 Molecular signaling events of brain-derived neurotrophic factor-mitogen-activated protein kinase pathway and depression PYY FRS2 GRB2 BDNF PMC6482021__F2 Thyroid enlargement in patients with homozygous INSR mutation IGF1 INSR PMC7327477__F7 Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage RPL5 RPL11 SKP2 PMC8067938__F1 Hippo signaling: bridging the gap between cancer and neurodegenerative disorders RASSF6 RASSF2 RASSF1 ZYX RASSF4 AREG MYC VGLL4 FRMD6 LATS2 WWC1 WWC2 SCRIB AJUBA NF2 PMC5241894__F7 Insulin-like growth factor receptor 1 (IGF-1R)– and mammalian target of rapamycin (mTOR)–induced alterations upon the canonical IGF-1R signaling cascade, mitogen-activated protein kinase (MAPK) and receptor tyrosine kinase RTKs in Ewing sarcoma (ES) IGFBP2 PTEN MTOR IGF2 IRS1 EIF4E RHEB TSC2 RICTOR TSC1 IGF1 PIR EEF2 GRB2 PMC3488811__F1 Simplified diagram of choline-related one-carbon metabolism MTHFD1 PEMT PC PMC4431853__F7 House Dust Mite Allergen Regulates Constitutive Apoptosis of Normal and Asthmatic Neutrophils via Toll-Like Receptor 4 TLR4 S100A8 LYN S100A9 PMC5597960__F7 Systemic lupus erythematosus (SLE)-activated platelets induce endothelial cell activation via an interleukin-1B (IL-1B) pathway LPA IL1B PMC7230029__F1 Chromothripsis and telomere crisis: engines of genome instability TBK1 CGAS IRF3 TREX1 PMC10242177__F1 Myostatin: a potential therapeutic target for metabolic syndrome GDF8 SMAD2 SMAD4 PMC9704363__F6 Noncoding RNAs in cancer lipid metabolism ACLY ACSL1 HMGCR GLS SQLE FASN FACL4 PMC3574928__F1 De novo purine biosynthetic pathway in humans PAICS ASL HEL-S-70p PMC7937683__F8 Loss of desmoglein-2 promotes gallbladder carcinoma progression and resistance to EGFR-targeted therapy through Src kinase activation EGF EGFR DSG2 PMC4287361__F1 Epstein-Barr virus Associated B-cell lymphomas: Pathogenesis and Clinical Outcomes SYK CDK6 TRADD CDK2 LYN MDM2 CCND1 RUNX3 PMC9576796__F5 Proposed metabolic pathway for anaerobic propane oxidation coupled to nitrate reduction PCCB FADD PMC9704363__F5 Noncoding RNAs in cancer lipid metabolism RARA ACSL1 NR1C1 FASN MTOR PMC3827622__F5 Proposed genetic networks of osseointegration NPAS2 SOX9 PER2 BMP2 EPO RUNX2 CTNNB1 PMC4646252__F1 Interaction between SAMHD1 and deoxyguanosine kinase activities in the regulation of mitochondrial dGTP PNP PMC3338780__F8 Receptor Tyrosine Kinases Activate Canonical WNT/Beta-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct Beta-Catenin Phosphorylation APC AXIN1 LRP6 CTNNB1 PMC8234227__F4 Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers BAX FAS ULK1 MTOR XBP1 TRAF2 FADD PMC11941373__F7 Impact of DNA damage pathways on improving anticancer efficiency and reducing systemic drug resistance RAD51 BRCA1 ATM PMC8163534__F8 Pharmacological Mechanisms Underlying the Therapeutic Effects of Danhong Injection on Cerebral Ischemia MAK PTEN PMC7981155__F2 WNT5a in Colorectal Cancer: Research Progress and Challenges APC ROR2 LRP5 LRP6 RHO CTNNB1 PMC5393392__F3 Protein interactions during the flavivirus life cycle elucidated by MS-based proteomics HRAS GBF1 APOE RAB18 TSG101 ME1 RAP2B PREB SRFBP1 NUP98 PMC6863093__F4 HVEM behaves as bidirectional switch based on environmental signals: CSA2 LTA CD160 BTLA TRAF2 PMC4569046__F5 Microbial subversion of neutrophil function leads to periodontal inflammation TLR1 SMURF1 MAL ARHA MYD88 PMC6863093__F2 PD-1 exerts intrinsic suppression of T cell activity proximal to the TCR: ZAP70 APC PMC6379961__F1 Overview of PI3K/AKT/mTOR signaling pathway PTEN MTOR PMC7582747__F3 Proposed regulation of PlGF and TGFB in early diabetic retinopathy TGFBR2 PIGF PRDX3 ANGPT1 EDN2 SMAD2 PECAM1 PMC8913403__F3 Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review BAX CAD PMC6425641__F1 Schematic presentation of strategy for SLA-PEB biosynthesis in E SLA EMD PMC4098112__F1 Regulation of muscle mass IGF1 SMAD2 SMAD4 IRS1 PMC5110029__F1 Type I interferon signaling and type I interferonopathies as currently assigned CGAS MAVS STAT2 PSMB8 IRF9 IRF3 RNASEH2C RNASEH2B RNASEH2A STAT1 POLA1 IFNAR2 USP18 IFNAR1 ISG15 JAK1 TREX1 TYK2 ACP5 PMC6010520__F9 Proposed model for illustrating the essential roles of DNA sensors in recognition and innate interferons (IFNs) production during ectromelia virus (ECTV) infection TBK1 CGAS TLR9 DDX41 IRF3 IRF7 PMC3051001__F1 RIP1 COMES BACK TO LIFE AS A CELL DEATH REGULATOR IN TNFR1 SIGALING CD40 TNF TRAF2 PMC9343696__F1 Crosstalk between the CBM complex/NFKB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment STAT3 CDK6 SIAH2 E2F4 E2F7 SHE KRAS CDK4 PMC6889822__F4 Multiplexed Proteome Profiling of Carbon Source Perturbations in Two Yeast Species with SL-SP3-TMT HEL60 ACO2 HEL-S-26 PMC7294914__F7 Proposed mechanism by which melatonin protects human renal proximal tubule epithelial cells against high glucose-induced fibrosis through the upregulation of PrPC CDH11 SMAD2 PMC10917537__F1 Fundamental ferroptosis-related intracellular pathways and mitochondrial regulation VDAC3 LOX GPX4 FACL4 GLS2 GPT PMC3216277__F5 Pathways underlying the absorption of cholesterol from the intestinal lumen and its delivery to the liver ABCG8 ABCG5 ACAT2 NPC1L1 PMC8124548__F3 Inhibitors of Chemoresistance Pathways in Combination with Ara-C to Overcome Multidrug Resistance in AML. A Mini Review BAX BAD MEI1 MTOR PMC3216277__F1 Within the intestinal lumen, the micellar solubilization of sterols facilitates movement through the diffusion barrier overlying the surface of the absorptive cells TG ABCG8 ABCG5 MTTP HMGCR ACAT2 HEL-S-5 PMC4632709__F3 Single network includes most splice regulatory genes dysregulated in MS SPEN MED4 MED19 MED10 PTEN PCBP1 SCAF11 CSTF3 MYC POLR2J MED31 YTHDC1 MED18 CD24 MBNL1 EIF3G MED9 HNRNPH1 HNRNPA2B1 MED22 TRFP NFE2L2 CCNB1 TRA2B PMC3549263__F3 Low-dose radiation responsive genes linked to carcinogenesis SP1 PCNA IRS1 PMC2872667__F4 Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling PLN TIMP3 CYTL1 EGR1 PTN HSPG2 SPARC PTPRK POSTN SOX9 CLU MMP2 DCN PMC8356007__F7 Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research HRAS BTK FER INSR SELE KIT GCK PMC8313238__F5 CD38 in the age of COVID-19: a medical perspective TMPRSS2 TRPM2 NLRP3 TLR7 CCL2 TNF IL1B MYD88 PMC2872667__F3 Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling CDH2 BGLAP CAV2 PTN EGFR FZD7 RUNX2 DOCK1 FGFR2 NCAM1 MUC20 FGFR1 ADAM12 CXCR4 PMC7591852__F3 Dopamine-induced interactions of female mouse hypothalamic proteins with progestin receptor-A in the absence of hormone FH ACO2 HEL-S-133P ME1 HEL-S-30 HEL-S-128m DLAT PCSK1N HEL-S-2a PRDX5 DLD HEL-S-32 MDH2 PFKM PMC4811921__F3 Latency-associated nuclear antigen-mediated deregulation of cell cycle CDC2 BRD4 ATR CDK2 ATM MDM2 ID1 CDC25B BRD2 CDK4 PMC8568584__F7 Direct modulation of hepatocyte hepcidin signaling by iron STAT3 BMP6 SMAD1 DKFZp781O1323 NOX4 PMC10758887__F16 Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives DKK1 APC LRP5 LRP6 CTNNB1 PMC11021710__F3 Cell cycle signaling pathway (A) and cellular senescence (B) TICRR MAU2 BUB1B MYBL2 STAG1 SMC3 SMAD2 GSK3B SMAD4 ORC1L CCNA2 MYC SKP2 PLK1 RB1 CDKN2A CDK6 CCNE1 E2F4 WEE1 WAPAL HEL-S-1 MDM2 ESPL1 TFDP1 SMC1A HRAS RHEB RAD21 KNL1 MTBP FOXO1 DDX11 AURKB CDC45 CDK2 CDC27 MCM2 GADD45A ATR TGFB1 CDC20 PCNA CDC6 ESCO1 SFN PPP2CA CDT1 MTOR CCNH BTRC CDK7 TTK ATM SGOL1 CCNB1 CCND1 DBF4 CDC2 TRIP13 KNTC2 MAD2L1 RBL1 PTTG1 FZR1 FOXO3A PRKDC CHEK1 SKP1 GATA4 NIPBL PMC1458968__F4 Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin CDH2 TEF CTNNB1 PMC4447079__F2 Illustration of protein modification by the ubiquitin proteasome system NEDD8 SUMO1 MVD PMC4710869__F1 Simplified schematic summarizing the BMP signalling pathway and genes that have to date been shown to be mutated in PAH and demonstrating that many of these mutations encode protein involved in BMP signalling BMP10 KCNK3 PMC2666388__F1 DHA, NPD1, and BAPP-derived AB peptide signaling circuits in homeostatic aging and in AD SORL1 APOE HEL-S-5 ADAM10 PMC11580055__F7 Mechanism of EE improving secondary brain injury after TBI through the TLR2/NFKB/MMP9 pathway MMP9 TNF PMC5412475__F1 Schematic presentation of the postsynaptic structure and function on the basis of acetylcholine receptor clustering centered on agrin- and Wnt-signalings, trans-synaptic communication and synaptic stabilization ACHE MUSK ERBIN CRK LRP4 NRG1 CRKL RHO RAC1 CTNNB1 PMC6502894__F1 Diagram showing the main paracrine and dichotomic autocrine functions of the IL-6/JAK/STAT3 pathway in the pathophysiology of skeletal muscle STAT3 FAP DMD PMC6939830__F1 S1P-S1P receptor signaling system MFSD2B SPNS2 RHO PMC7068780__F4 Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis IL27 MYC HLA-C PMC5601165__F2 Genetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions STAT3 MOS PDGFRA KIT MTOR SRC MYC PMC11604675__F1 Fusobacterium nucleatum facilitates the metastasis of CRC via modulating the expression of FadA-Wnt/catenin signaling cascade and NFKB/TLR4/MYD88 signaling pathway TLR4 CCND1 CCL20 CTNNB1 MYD88 PMC8465622__F1 Repurposing Small Molecules to Target PPARG as New Therapies for Peripheral Nerve Injuries CD44 STAT3 GAP43 ARHA PMC7279384__F2 Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation STAT3 GHSR POMC AgRP PMC4964491__F3 Flii involvement in inflammation TLR4 LRRFIP2 FLII TRAF6 MYD88 PMC7943556__F1 Signaling by the phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway EGFR PTEN IGF1R PMC9604797__F2 Carotenoids from Marine Microalgae as Antimelanoma Agents RB1 CDK6 PTEN MDM2 CDK4 PMC9604797__F3 Carotenoids from Marine Microalgae as Antimelanoma Agents CDK6 GSK3B PTEN CCND1 CDK4 CTNNB1 PMC2631308__F1 Insulin resistance TG FAS INSR FOXO1 IRS1 PMC3252731__F1 TLR4 signaling pathway is highly regulated TBK1 TLR4 IRAK1 IRF3 TRAF6 IRAK4 MYD88 PMC4106326__F15 Model depicting how PPARB/D promotes H-RAS-induced cellular senescence, whereas ER stress attenuates H-RAS-induced cellular senescence PDPK1 HEL-S-28 MDM2 MTOR PMC5294958__F1 TGFB/Smad4 signaling pathway SMAD2 SMAD6 SMAD4 PMC7767754__F6 DDR pathway [, , ]: The DNA damage and response pathway: The figure depicts the causative agents and plausible DNA damage repair pathways ATR PARG H2AX ATM SSB PMC7521960__F2 COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis CD40 IL19 ZAP70 CXCL12 LTA LTBR TIRAP LAT NFKB2 TLR9 IRAK1 TRAF3 TRAF6 IKBKG MYD88 NGF BCL10 BCR TLR4 TLR8 HAO2 CHUK ATM TLR7 CYLD IL1B CD14 BLNK CD40LG IRF3 PTGS2 LTB CCL13 TLR3 NFKB1 NFKBIA TRAF5 CCL4 LYN VCAM1 LBP TRAF2 EDAR TNLG7C LCK PMC4316787__F4 Fourth-ranked enriched canonical pathway identified using IPA at 2 hpi – the CD40 signaling pathway STAT3 LTA FCER2 MAPKAPK2 JAK3 TRAF5 ATF1 TRAF1 TRAF6 TRAF2 PMC4316787__F3 Top-ranked enriched canonical pathway identified using IPA at 2 hpi – the IL-10 signaling pathway STAT3 HMOX1 SP1 SOCS3 JAK1 TYK2 LBP PMC7543045__F9 Schematic model showing G10 activation of the NLRP3 inflammasome in porcine cells TBK1 NLRP3 IL18 IRF3 IL1B PMC6938671__F1 Two predominant DSB repair pathways in mammalian cells RAD52 RAD51 RMI2 WRN BRCA2 BLM PNKP TOP3A DNA2 BRCA1 GEN1 SLX4 EME1 PMC11688383__F1 ER stress and activation of the UPR signaling pathways ATF4 XBP1 PMC8275894__F1 Function, Failure, and the Future Potential of Tregs in Type 1 Diabetes PTPN22 IL2RA IL2 AIRE FOXP3 PMC11688383__F2 Insults to airway epithelial cells, their impact on UPR and the consequences of UPR activation ATF4 XBP1 PMC11688383__F3 Inflammatory signaling pathway regulated by UPR ATF5 TXNIP ATF4 TRAF2 PMC7573563__F1 Innate immune response during ADE and non-ADE dengue infection RIGI TLR3 TANK TLR7 SOCS3 PMC11688383__F5 ER stress-mediated autophagy and the possible mechanisms ATG101 ATG12 ULK1 UVRAG ATF4 ATG5 TRAF2 PMC4980033__F3 Modelling the Structure and Dynamics of Biological Pathways NDC1 TPR NUP214 POM121 PMC8192490__F3 miR-940 is a new biomarker with tumor diagnostic and prognostic value MMP7 STAT3 BAX CCND1 CDK4 CTNNB1 PMC2642890__F2 Posttranscriptional regulation of gene networks by GREs HTRA2 UBE3A PPM1D MYB ATR BAD FAS SMAD4 PPP2CA MYC PLK1 XBP1 CCNH HSF2 RARA BCL10 CDK7 DNAJB9 ROCK1 WEE1 AHR ATM MDM2 APAF1 BAX JUN ETS2 SIN3A CAD SIAH1 SGK1 GTF2E1 IRF4 TNF NR3C2 RUNX1 BTG2 FOXO1 CDK2 TRAF1 NFYC ING1 EGR2 GADD45A BCL6 DIABLO PMC11814165__F2 Illustrating of the binding mechanisms of berberine with PLA2, MD2, BACE1, AB1-42, TGFBR1, and JAK2 in human cells COX1 TLR4 BACE1 APP MYD88 TGFBR1 PMC6558179__F5 Underlying mechanism of SSa on T cell-mediated immune surveillance in breast cancer STAT4 TYK2 PMC5702962__F1 Structure of (A) HGF and (B) Met CDC42 STAT3 HGF RAF1 GRB2 MTOR RAC1 PMC8616147__F6 RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERA)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2 FOXM1 YAP1 PMC10937431__F4 Signalling pathways and targets of botanical medicine flavonoids against CIRI-induced PANoptosis and ferroptosis CASP8 TRADD KEAP1 GPX4 MLKL LPCAT3 TAB3 FACL4 DFNA5 TNF NLRC4 RIPK3 GSDMD ZBP1 TRAF5 RIPK1 HEL-S-64p TRAF2 FADD PMC5303000__F2 Role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia NDRG2 GLS NDRG3 NDRG4 HK2 MYC CTNNB1 VHL PMC4323240__F7 Macrophage Activities in Proliferation, Lysosome, and Phagosome by the Nonspecific Immunostimulator, Mica MALL PCNA PI3 SMAD4 CDK2 MYT1 CA14 PMC6803663__F1 Flow diagram illustrating the molecular methodology and frequency results of CRC cases diagnosed between 2011–2012 MSH6 MSH2 PMS2 PMC3991965__F2 Prostaglandin Analogues on Aqueous Humor Outflow Pathways TF EGFR RHO CTNNB1 PMC9460961__F2 Combination strategies to optimize the efficacy of chimeric antigen receptor T cell therapy in haematological malignancies CD80 TIGIT BTK BCR ITK MTOR CD3G PMC7339783__F9 Graphic summary of the findings of the present study HMGB1 TLR4 IL1B PMC10937431__F3 Signalling pathways and targets of botanical medicine flavonoids against CIRI-induced autophagy GABARAP ATG3 ATG16L1 ATG12 ULK1 AMBRA1 ATG14 MTOR ATG5 PMC8508861__F3 Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer BAX TRADD FADD PMC4433804__F1 Catalytic mechanism of a retinoid isomerase essential for vertebrate vision LRAT RPE65 RDH5 PMC9277309__F5 Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD SMYD2 PKD1 MIF MTOR SIRT1 PMC7728437__F1 On-Off DSGCs in Gabra2 cKO mice show reduced direction selectivity and reduced null-direction inhibition in the noisy background GABRA2 WAC PMC9277309__F3 Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD FAS BCL2 TNF PMC6927547__F1 Key anti-obesity strategies and pharmacological agents ADRB3 STAT3 PRDM16 UCP1 RBPJ PMC3879631__F6 Model for potential roles of SIRT7 in ribosome biogenesis SIRT7 MTOR PMC5008583__F3 KEGG in Graphviz view of T-cell receptor signaling pathways on a canonical signaling pathway with gene methylation chip data ZAP70 PIK3CA PDCD1 RAF1 SOS1 NFATC2 LAT PPP3CA MAP3K14 IKBKG MAPK14 MAP3K8 PLCG1 PTPRO FYN BCL10 CHUK ITK LCP2 NCK1 VAV1 CD40LG CTLA4 ARHA KRAS FOS ICOS TG PAK1 NFKB1 IKBKB NFKBIA MAP2K1 GRB2 CD3E LCK PMC4440424__F2 Class I PI3K pathway RHEB TSC2 BAD RICTOR TSC1 FOXO1 PDPK1 PTEN MDM2 GRB2 MTOR PMC5008583__F4 KEGG in Graphviz view of Jak–STAT signaling pathways on a canonical signaling pathway with gene methylation chip data SOCS1 CCND3 PIK3CA PIM1 SOS1 STAT2 IRF9 JAK3 PTPN1 MYC PTPN6 CNTFR BCL2L1 SPRED1 CREBBP GRB2 CISH STAM2 SPRY1 PMC4214394__F1 Activation of mammalian target of rapamycin occurs through a complex signaling cascade RHEB EEF2K TSC2 RICTOR TSC1 EEF2 MTOR BDNF PMC8797727__F3 p16 a biomarker of aging and tolerance for cancer therapy CDK6 CDKN2B MDM2 CDK4 PMC5343994__F1 Mutation in the von Hippel–Lindau gene (VHL) induces loss (red ×: HIF-2a is no longer inhibited) of the regulatory tumour suppressor p-VHL and catalyses the “von Hippel–Lindau-hypoxia-inducible factor” VHL-HIF pathway TPR TGFA VHL PMC7074405__F1 Curcumin exerts various effects on the malignant activities of tumor cells STAT3 HGF CCND1 PMC8709963__F9 Dietary supplementation of inulin alleviates metabolism disorders in gestational diabetes mellitus mice via RENT/AKT/IRS/GLUT4 pathway TG PHKA1 PDK4 RETN IGFBP5 PGM3 HEL-S-68p PFKL PDK2 PMC5192396__F2 Inhibition of ribonuclease L (RNase L) activation by picornavirus proteins MAVS G3BP2 RNASEL IRF3 IRF7 PMC5876656__F1 The Hippo signaling pathway is composed of neurofibromin 2 (NF2), mammalian STE20-like protein kinase 1/2 (Mst1/2) and large tumor suppressor 1/2 (Lats1/2) LATS1 LATS2 NF2 PMC3285398__F1 Toll-like Receptors (TLRs) recognize specialized structural motifs on the microbes known as pathogen-associated molecular patterns (PAMPs) TBK1 TIRAP TLR9 IRAK1 TLR5 IRF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC3285398__F2 Proposed mechanisms of interaction between TLRs and MUCs: I GSK3B ERBB2 TRAF6 IRAK4 CTNNB1 PMC4625546__F1 Is Retinol Binding Protein 4 a Link Between Adiposity and Cancer? STAT3 LRAT PMC7099488__F1 Bile acid synthesis in the liver CYP8B1 BAAT CYP7A1 CH25H GCA CYP46A1 CYP7B1 CYP27A1 PMC7296156__F3 Biological properties of cmvIL10 in myeloid progenitors (during lytic infection) STAT3 HLA-G CD14 CXCR4 PMC2650409__F6 c-Src Regulates Akt Signaling in Response to Ghrelin via Beta-Arrestin Signaling-Independent and -Dependent Mechanisms MLST8 REST RICTOR MTOR PMC5879999__F1 Metabolic interventions suggested by OptForce for increasing production of octanoic acid (C8) in E MAL HACD3 FADD CIT PMC7016617__F2 Signaling pathways modulated by SCD1 activity and levels BAX BAD APC GSK3B ATF4 NOX4 CTNNB1 PMC9179486__F1 Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated HEL-S-90n KYNU KMO AFMID PMC4048950__F10 Redox control of p53 in the transcriptional regulation of TGFB1 target genes through SMAD cooperativity ATR USF2 EGFR SMAD2 SMAD4 ATM PMC9179486__F3 Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated KYNU KMO AFMID ID1 PMC2724105__F2 The postreceptor insulin signaling pathway and insulin-independent 5′-adenosine monophosphate kinase (AMPK) beginning from insulin binding to its receptor to GLUT4 translocation via vesicular trafficking PTEN PDK2 INS PMC7407683__F5 FSH and ovarian cancer SOX2 PTEN HIF1A CCND1 TRPC3 PMC9495820__F8 Formyl-Peptide Receptor 2 Signaling Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming of Lung Cancer Cells CAD GLS ANXA1 FPR2 PMC10887103__F5 Defective PI3K/Akt pathway in T2DM results in insulin resistance and the activation of the pro-inflammatory, pro-apoptotic inhibition of eNOS and glycogen production RYR2 PLN MTOR PMC7407683__F1 FSHR is expressed in multiple organs related to metabolic diseases and FSH/FSHR participates in the regulation of cellular activities and metabolic processes LPL FAS RARB DGAT2 LDLR RDH10 UCP1 MTOR FSHR PMC7407683__F2 FSH and obesity LPL FAS RARB DGAT2 RDH10 FSHR PMC3427269__F1 AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway STAT3 IL6 JAK1 SRC KRAS PMC6515458__F3 Protein–protein interaction (PPI) network in muscle wasting in cancer cachexia STAT3 CXCL12 GDF8 GABARAPL1 UCP3 BNIP3 SOCS3 PCK1 TRIM63 MEF2C FBXO32 TUBA4A FST KCNIP4 MMP3 HSP90AB1 TUBA1A C1S JUNB HSD11B1 PNPLA2 NR3C1 HGS TSC2 FOXO1 PAK1 NUDC ANGPTL7 MYH8 HP PMC6515458__F1 MicroRNA-regulated networks in muscle wasting during cancer cachexia based on meta-analysis data STAT3 CXCL12 GDF8 GABARAPL1 FOXO1 JUNB BNIP3 SOCS3 TRIM63 MEF2C NR3C1 FBXO32 PMC2694962__F1 Schematic illustration of overview of one-carbon metabolism pathway, linking to methylation reactions and nucleotide synthesis RFC1 MTRR HEL-S-61p MTR PMC9333902__F1 Immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review) TRIM25 TLR3 IRF3 PMC8799426__F3 Trend of CRISPR-Based Technologies in COVID-19 Disease: Beyond Genome Editing ACE2 PMC9343696__F2 Crosstalk between the CBM complex/NFKB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment BCL10 TRAF6 PMC11876862__F1 Mechanisms of protein degradation and synthesis in muscles STAT3 SMAD1 GDF8 PINK1 DKFZp781O1323 IGF1 ATG12 GDF11 SMAD2 SMAD4 BNIP3 MTOR PMC7540572__F1 Tricin biosynthetic pathway from the key pathway‐branching intermediate, p‐coumaroyl‐CoA, with generic enzymes in grasses noted in green (Lam et al., ; Eloy et al., ), and in red are those from Medicago sativa (Ms) and M CAD F3 STS PMC7846970__F3 ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease HEL-S-8a ROCK2 MGRA ARHA PMC3141233__F7 A model for the role of FANCD2 in Ad replication-dependent recombination FANCD2 ATR BLM PMC3322146__F8 Role of miR-148a in Hepatitis B Associated Hepatocellular Carcinoma PTEN CTNNB1 PMC4996367__F1 Immune cell-derived complement on T cell immune responses CD40 NLRP3 HEL-S-62p APC CD46 PMC4730276__F2 EGFR function in hepatocytes and Kupffer cells during hepatocellular carcinoma (HCC) formation ADAM17 EGFR IL6 IL6R MYD88 PMC9453478__F1 Fanconi anemia and dyskeratosis congenita/telomere biology disorders: Two inherited bone marrow failure syndromes with genomic instability FANCD2 RAD51C REV1 FANCM FAAP24 PALB2 SLX4 RPA1 PMC8888452__F1 Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies MAML1 SMAD2 APC SMAD4 EP300 MTOR TNF RBPJ CTNNB1 PMC6381758__F7 Modified KEGG map of the JNK and p38 MAP kinase signaling pathway showing transcriptional changes MAX HEL-S-31 DUSP5 FAS PTPN5 TGFB1 TRADD TNFRSF1A MAPKAPK3 MAP3K11 ATF2 MEF2C TGFBR1 DUSP3 TGFBR2 MAP2K6 MAP2K4 HSPA2 MAP2K3 HEL-S-72p MAP4K3 JUN MAP4K1 TNFSF6 MAPKAPK2 RPS6KA4 DUSP4 NFATC1 TNF MAP3K1 HEL-S-102 DDIT3 MAP3K5 NFATC3 RPS6KA5 TRAF2 CDC25B PMC9023592__F1 Product of AS of pre-mRNA: lncRNA MAX IFNG IFI6 IFIT1 IFITM1 PMC8377458__F2 Narrative Review of the Renin-Angiotensin-Aldosterone System in the Placenta and Placental Bed of HIV Infected Women of African Ancestry with Preeclampsia KCNQ3 KCNQ2 COX2 PMC8639599__F1 Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia CDH2 MPL CCL3 MSC THPO NOTCH1 PMC7432306__F4 Reconstructed metabolic map of xanthan biosynthesis in Xpm PPIC RPE PPIE TNLG7C PMC8639599__F2 Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia CD44 CXCL12 MSC CXCR4 EMCN CD34 PMC3956502__F4 Mechanisms underlying the inhibition of interferon signaling by viruses STAT2 JAK1 TYK2 PMC4504428__F2 MDM2-p53 Pathway in Hepatocellular Carcinoma SIRT3 KLF6 MDM2 ING1 PMC2905205__F1 Signalling routes of copper and hydrogen peroxide ABI2 HEL-S-162eP PMC9558762__F3 Physiological and pathological roles of Hic-5 in several organs (Review) LOX TLR4 SMAD2 SMAD4 TCF4 ARHA CTNNB1 FADD PMC8291223__F8 A High-Grain Diet With a Buffering Agent on Milk Protein Synthesis in Lactating Goats RHEB EEF2K EIF4B EEF2 MTOR LAT2 CSN2 EIF4E PMC9389465__F2 Glucose transporters: Important regulators of endometrial cancer therapy sensitivity EGF ABHD5 HTRA3 MTOR PMC4050178__F1 Brief Overview of DNA Damage Repair: Three common types of DNA damage are depicted in this image as well as an summary of the pathways/proteins that are activated in response to each type of damage ATR ATRIP ATM SSB PMC5204344__F4 let-7c and miR-10b target multiple genes in regulatory networks TRIO MASTL RSF1 DYRK1B SMAD6 ASXL1 RBP4 KIT SDC1 E2F5 GMNN CHD4 PKD1 ALDH1A3 CTBP2 NCOR1 CRABP2 CENPP TRIM71 MBD3 RPS6KA5 PMC8804744__F3 Mitochondria in Physiology of Chondrocytes and Diseases of Osteoarthritis and Rheumatoid Arthritis BAX EGF IL1B PMC11863469__F10 PI3K/AKT/mTOR pathway in GBM progression RHEB MLST8 TSC2 BAD TSC1 PTEN DEPTOR EIF4E PMC7656585__F2 CP-25 on cells and possible mechanisms CD40 TH CD80 CXCL12 CXCL13 CD27 ACD ARG1 CD19 ADRBK1 CD83 CXCR5 CXCR4 TRAF2 IL1B PMC11863469__F11 TGFB signaling in GBM progression TGFBI SMAD2 IL2 PMC4397972__F4 Gene network analysis for 18 key genes involved in age-dependent tumor progression BAX S100A4 TGFB1 B4GALT1 HEL-S-269 EIF3A SDC1 HEL-S-94n CTNNB1 HEL-S-99n ARHGDIB HEXA EXT2 CASP3 CCNB1 POLR2A FADD PMC11863469__F12 Notch signaling in GBM progression HEY2 PTEN HES1 PMC6894939__F2 Gluconeogenesis in cancer cells – repurposing of a starvation-induced metabolic pathway? PCK2 FBP2 MAL FBP1 PC PCK1 CIT PMC8290014__F6 TLR4 in parthanatos and the MyD88 and/or the PI3K signaling pathway in parthanatos TLR4 EGFR MYD88 PMC9366916__F3 Breaking the aging epigenetic barrier ATR RAD50 ATM PMC6894939__F5 Gluconeogenesis in cancer cells – repurposing of a starvation-induced metabolic pathway? PCK2 FBP1 PC PCK1 PMC6148080__F19 SST5signaling leading to inhibition of hormone secretion and proliferation GAL GC HEL-S-11 MTOR SST PMC9177323__F6 Single-Cell Analysis Reveals the Role of the Neuropeptide Receptor FPR2 in Monocytes in Kawasaki Disease: A Bioinformatic Study TH HEL-S-99n ACTR2 TFRC LCP1 HEL-S-68p TPM3 CACYBP PMC11764157__F6 CBG on AD models TSLP IL33 JAK1 TYK2 IL1B PMC3469658__F5 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes TUBA1A HEL113 LCP1 APP MYC IL1B PMC8705098__F2 Complement System in Alzheimer’s Disease HEL-S-62p C4B_2 PMC3469658__F6 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes NAIP ARHGDIB HSPD1 PPP5C HSH2D HEL57 CASP3 HEL-S-52 CTNNA1 TNF RETNLB UNK PMC3469658__F3 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes RPL8 IL15 FACL4 SNX6 MYC RPL37 LXN RPL39 PDZD2 IL2 HEL-S-66 CUTC CD244 ARRB2 TNF HRAS NR2A1 CNN3 PHGDH PHF5A RPL7L1 TPP2 RPS12 NDUFS1 YWHAZ PMC3469658__F4 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes IL15 NOS2 SELL EGFR PLEKHA2 TREML2 SNX6 TNF NR2A1 PHGDH HEL-S-66 SNX2 GNG11 AKAP12 BRD2 TIA1 CRBN PMC4100211__F1 Proposed frame work for mRNA nanoparticle mediated tumour vaccination CD40 CD80 TLR3 CD27 TNLG8A IRF3 TLR7 MYD88 PMC6370632__F1 Signal transduction pathway related to the immune-regulation of botanical polysaccharides in macrophage activation JUN CD14 TRAF6 FOS MYD88 PMC3144530__F1 Schematic overview of proposed G protein-coupled oestrogen receptor 1 (GPER1) signalling HBEGF EGFR GPER SRC PMC6620384__F1 Regulatory mechanisms of Robo4 and their effects on angiogenesis SLIT2 ARF6 VEGFA ROBO1 SRC ROBO4 PMC4280516__F2 Cellular entry of HCV particles HRAS CD81 EGFR LDLR CLDN1 PMC3969788__F4 Strategies for Delivery of Therapeutics into the Central Nervous System for Treatment of Lysosomal Storage Disorders RHO SRC EEA1 PMC3959213__F10 Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway PRMT1 F2 PMC7957493__F4 Mutations in components of niche-signalling pathways lead to “ISC emancipation” and subversion of homeostatic mechanisms SFRP5 EGF HGF GSK3B SMAD4 PTEN RHO MYC FBXW7 BMP4 GREM1 GPR49 HES1 NOTCH1 SNAI2 APC IL17A ASCL2 AXIN2 SFRP1 CD44 IL17RA SFRP4 RNF43 BMP2 PMC11863469__F17 SHH signaling pathway in GBM, particularly in GSCs: In the absence of the hedgehog (HH) ligand, the Ptch receptor inhibits Smo, leading to the formation of GliR, a repressor that suppresses the expression of target genes SUFU SHH SMO PMC6024750__F3 Outline of the three main pathways of colon carcinogenesis PMS1 MSH6 MSH2 APC BRAF KRAS MGMT PMC3631444__F6 The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells HSD17B3 STAR CYP17A1 DHRS9 CYP11A1 PMC6594622__F5 Tumor- and cytokine-primed human natural killer cells exhibit distinct phenotypic and transcriptional signatures CXCL9 CLIC4 TNFAIP3 TXK TNLG8A BMX IL1A TNF CXCL11 TEC BTK ITK TRAF1 CCL8 TNFSF10 BIRC3 PMC11863469__F16 Complex and dynamic interactions between signaling pathways in shaping GBM progression, therapeutic resistance, and disease outcomes (*To draw this figure, data from the reports in references [39, 146, 155, 245, 249, 294, 333–380] were used CDC42 CD44 DDR1 IGF1 EGFR BRAF ARHA RAC1 PMC6148080__F20 Differential trafficking of somatostatin receptors HEL-S-69p PPIG SST PMC8649443__F6 Metabolic endophenotype associated with right ventricular glucose uptake in pulmonary hypertension ALDH18A1 GLS ARG1 PMC4357780__F3 iBIG: An Integrative Network Tool for Supporting Human Disease Mechanism Studies IFNG MAFK COMP PMC6176117__F3 Schematic outline of the intracellular signalization in the retinohypothalamic tract PER1 BDNF SIRT1 PMC5610669__F3 Examples of IGF-targeted agents IGF1 IGF1R IGF2 PMC5610669__F4 Crosstalk between IGF-1R and other RTKs/steroid hormone receptors ALK INSR EGFR IGF1R MTOR IRS1 PMC5564764__F7 BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways STAT3 BMX MTOR PMC8972406__F1 Solar-Driven Producing of Value-Added Chemicals with Organic Semiconductor-Bacteria Biohybrid System NHS PTS THRA PMC4103166__F3 Circadian Clock in Cancer Development and Therapy ATM CTNNB1 PMC3691869__F6 Schematic outline of the regulation of EGFR internalization and mediated signaling by the CIN85–SH3GL2–Cbl complex STAT3 EGF EGFR SH3GL2 CTNNB1 PMC6601370__F10 KEGG pathways enriched by the differentially expressed mRNAs in the competing endogenous RNA network CAD LAT RHO DAO PMC10536053__F3 Targeting DNA Damage Repair and Immune Checkpoint Proteins for Optimizing the Treatment of Endometrial Cancer ERCC1 RAD52 DNA2 PAXX POLE BLM PMC10536053__F4 Targeting DNA Damage Repair and Immune Checkpoint Proteins for Optimizing the Treatment of Endometrial Cancer IL15 CDC2 TBK1 ATR CGAS RAD50 IRF3 CCL5 CXCL10 SSB WEE1 CDK2 ATM PMC4401125__F1A HSPs regulatory function in the intrinsic (A), extrinsic and caspase independent pathways to death (B) BAX BAD CAD GATA1 PMC8666431__F7 Precise Identification of Recurrent Somatic Mutations in Oral Cancer Through Whole-Exome Sequencing Using Multiple Mutation Calling Pipelines PIK3CA ROS1 EGFR FGFR2 IGF2R ALK PLCB1 FGFR1 PRKCA FGFR3 ITPR2 EP300 PLCB3 PMC4201519__F2 Integrated microRNA and mRNA Transcriptome Sequencing Reveals the Potential Roles of miRNAs in Stage I Endometrioid Endometrial Carcinoma CDC2 DBF4 CDC20 PCNA CDC6 GSK3B SMAD4 ORC1L MYT1 SKP2 RAD21 CDK6 CDK7 E2F4 CDK2 MDM2 CSTA CDK4 PMC3287586__F2 Preimplantation development pathway KLF4 KRT18 GATA2 STAT3 PSG2 GCM1 SMAD1 THY1 RPS14 MYC TEAD4 CTNNB1 TLE2 CDX2 FGF7A AFP SNAI1 COX2 LEFTY1 BMP4 LEFTY2 HAND1 SOX17 ID2 LIF SOX2 FGF5C DPP3 DSC2 ESRRB TCF3 FOXD3 PARD3 SAP18 CER1 LAMB3 GJB3 GATA4 PMC10857159__F6 Expression of DEGs involved in the plant hormone signal transduction pathway of M TF BIN2 PMC10744863__F1 Pathophysiology of acquired aplastic anemia (AA) IFNG STAT3 FAS FOXP3 PMC10031108__F9 Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway BAX KEAP1 APAF1 PMC5610669__F1 Components of the insulin/IGF axis IGF2R IGF1 IGF1R IGF2 PMC5610669__F2 IGF-1R downstream signaling TSC2 BAD TSC1 IGF1 INSR PTEN IGF1R GRB2 IRS1 PMC8258330__F2 Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020 PANX1 SEMA3A TRPM5 PLCB2 OTOP1 CALHM3 PKD2L1 CALHM1 SEMA7A PMC4934657__F3 Fanconi Anemia Proteins, DNA Interstrand Crosslink Repair Pathways, and Cancer Therapy ATR USP1 PALB2 UBE2T PMC8687625__F9 Detecting Critical Functional Ingredients Group and Mechanism of Xuebijing Injection in Treating Sepsis SYK BAD FRK CD14 TNF RAC1 tal-1 MID1 BCR TLR4 ATM VCAM1 MIP ADA PMC8824883__F2 Cell division control protein 42 in tumor and non-tumor diseases: A systematic review CDC42 EGFR CTNNB1 PMC9359465__F2 Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment VCAM1 RHO TNF RAC1 PMC5749629__F2 Hepatic methionine metabolism is closely linked to GSH synthesis HEL-S-61p PMC8625415__F8 Prognostic Biomarkers of NIMA (Never in Mitosis, Gene A)-Related Kinase (NEK) Family Members in Breast Cancer CDC20 SELL APC INCENP KNTC2 NSL1 CENPB PMC6150985__F2 P53 is the most important regulator in DNA damage BAX ATR ATM PMC6514907__F1 Enhancement of SUMOylation in glioblastoma contributes to alterations in multiple cellular processes leading to an increased malignant phenotype SUMO1 CDK6 SENP1 PIAS1 SAE1 PMC4732808__F9 Blockade of KCNN4 by Clt accelerates wound healing at least in part by transactivation of the PI3K pathway EGF EGFR KCNN4 CIT PMC4059167__F1 Canonical catecholaminergic neuron is one that generates dopamine, noradrenaline or adrenaline TH PNMT DBH PMC4144112__F1 Genistein modulates a critical TGFB signaling pathway in human prostate cancer ENG SMAD1 MAPKAPK2 PMC4876503__F6 Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a STAT1 MAVS IFNAR1 IFNA1 PMC9459389__F3 Mechanisms of ferroptosis and its role in alzheimer’s disease GLS GPX4 LPCAT3 GSK3B SLC7A11 FURIN PMC8191844__F1 Immunometabolism: Towards a Better Understanding the Mechanism of Parasitic Infection and Immunity ARG1 PTEN PMC6357148__F2 Filovirus replication cycle showing host and viral proteins that either promote (green boxes) or block (red boxes) virion assembly and release WWP1 BAG3 NEDD4 ITCH TSG101 SOCS3 ISG15 PMC7519203__F2 Proposed mechanisms and time course of SARS-CoV-2 infection when using a ketone-based metabolic therapy TH PDK4 FOXO1 FOXO3A IRF3 HIF1A ACE2 PMC4372177__F5 Top Kegg pathways enriched with aDMCs identified by the FatiGO analysis IFNG CAD FOXA3 INS HES1 HNF1A TNLG7C PMC5916961__F1 Mitochondria are a platform for pattern recognition receptors (PRRs) signal transduction and regulation ECSIT TLR1 MAVS NLRP3 TLR4 TANK IRF3 IRF7 TLR7 TRAF6 IL1B PMC7519203__F8 Proinflammatory signaling that occurs during viral infection and mechanisms through which R-BHB inhibits this signaling STAT3 OGT MAVS TXNIP PTMS IRAK1 IRF3 TRAF6 MYD88 NLRP3 NOD2 TLR8 TLR7 FADD PMC4261510__F1 Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 CCND1 TEF PMC3650620__F4 Cross-talk between insulin and inflammatory signaling pathways STAT3 TRADD NLRP3 TLR4 MIF MTOR TNF TRAF2 IRS1 PMC4261510__F2 Hippo signaling pathway NF2 PMC8504269__F2 Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells ARHA RUNX2 PMC10938139__F2 Research progress of periostin and osteoporosis APC LEF1 CTNNB1 PMC10938139__F1 Research progress of periostin and osteoporosis CAV3 BMP1 LRP5 MSC LRP6 PMC7349630__F2 Signaling pathways and mechanistic drivers of epithelial-mesenchymal transition (EMT) and endothelial-mesenchymal transition (EndMT) in age-related macular degeneration (AMD) VWF MTOR CTNNB1 PMC10669822__F6 “PPAR signaling pathway” was an upregulated KEGG pathway for the transcriptomics profiling of HMEC-1 treated with MPE (0 LPL UBC OLR1 AQP7 UCP1 HEL-S-28 PLTP CYP1A1 PMC8678153__F4 Synthetic lethality of ATM and ATR ATR WEE1 ATM PMC3660856__F3 Molecular Basis of DNA Recognition in the Immune System NLRP3 AIM2 IL1B PMC6873089__F2 Mutational landscape of HCC KEAP1 APC PTEN TERT MTOR VEGFA HEL-S-78p KRAS FGF8A ALB RB1 CDKN2A TSC2 TSC1 CCNE1 PI3 AXIN1 NFE2L2 ATM ARID2 APOB IL6ST RPS6KA3 JAK1 PMC9599207__F1 Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside LATS1 LATS2 YAP1 PMC12130507__F5 KEGG pathways “VEGF signaling pathway”, significantly associated with CD36 abundance CDC42 BAD COX2 PMC9599207__F2 Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside LATS2 YAP1 PMC12130507__F6 KEGG pathways “Glutamatergic Synapse”, significantly associated with CD36 abundance GLA DAO PMC8509025__F1 Molecular Functions and Pathways of Plastidial Starch Phosphorylase (PHO1) in Starch Metabolism: Current and Future Perspectives MOS FRK SHE GPT PMC5136711__F1 Diagrammatic representation of the extrinsic and intrinsic apoptotic pathways BAX CASP9 FAS CASP3 DIABLO FADD PMC12130507__F4 KEGG pathway “Regulation of lipolysis”, significantly associated with CD36 abundance COMP PDE3B TSHR INSR CIDEC NPY INS ACP7 PMC10672452__F1 LPS-induced inflammatory response of the innate immune system and the anti-inflammatory effect of LPS-binding peptides/proteins from marine invertebrates CD14 LBP MYD88 PMC9122124__F2 Macrophage: A Cell With Many Faces and Functions in Tuberculosis KLF4 CXCL9 STAT3 STAT1 BAD TLR4 CXCL1 HEL-S-5 CXCL10 ARG2 PMC5225790__F13 VEGF/VEGFR signalling pathway in normal vs SEMA3A NRP2 NF2 PMC8836075__F2 Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? NQO1 AHR SRC PMC7914659__F1 Three major sources of H2S: enzymatic pathway, nonenzymatic pathway, and bacterial origins DAO PMC5626595__F1 ANTAGONISM OF TYPE I INTERFERON BY FLAVIVIRUSES CGAS MAVS USP15 TRIM25 IFNAR2 IRF9 IFNAR1 IRF3 MX1 ATF2 ISG15 JAK1 PMC5626595__F2 ANTAGONISM OF TYPE I INTERFERON BY FLAVIVIRUSES CGAS MAVS STAT2 IRF9 IRF3 IRF7 STAT1 UBR4 IFNAR2 IFNAR1 MX1 ISG15 TRIM23 PMC5056327__F1 Phosphatidylinositol 3 kinase/Akt pathway TSC2 BAD TSC1 PFKFB2 CD19 PTEN MDM2 IRS1 PMC5225790__F11 Childhood neurofibromatosis type 2 (NF2) and related disorders: from bench to bedside and biologically targeted therapies HRAS PPIC SPRED1 SOS1 SHOC2 BRAF NRAS PTEN MDM2 KRAS PMC3047086__F9 Suggested modes of the involvement of Nrf2/ARE in the regulation of AML cell differentiation NR1i1 JUN KEAP1 MAF ATF2 FOS PMC10604902__F1 Oxidative stress from dysregulated NOX activation and mitochondrial dysfunction regulates the signaling pathways involved in initiating and maintaining AF CD44 RYR2 STAT3 CXCL1 IL8RB NOX4 PMC6202553__F4 Gene networks CXCL12 GAL NTRK2 KIT IGF2 VCAN ERBB3 PLAT IGFBP5 PDGFRA PTCH1 FGFR1 MMP2 BCL2 PSCA PMC9584359__F2 EBV-driven 1C pathway drives nucleotide and glutathione synthesis MTHFD2 MTHFD1 PHGDH MTHFD1L PSAT1 SLC25A32 SFXN1 HEL-S-51e PSPH PMC11880705__F3 NS1 in counteracting innate immunity1: Binding of NS1 to p85Beta-SH2 relieved p85B repression of p110a, activated PI3/Akt signaling, and inhibited the apoptotic program induced by influenza virus TRIM25 RNASEL IRF3 OAS1 PMC4702030__F4 A - Ingenuity pathway analysis of genes involved in human epithelial ovarian cancer (EOCs) and other associated diseases that have overlapping pathways TGFBR2 RB1 CDKN2A NF1 CHEK2 ATM PTEN EP300 PMC11885102__F4 Schematic diagram of the regulation of intestinal ACE2 on islet function ACE2 GPR142 PMC5642919__F5 Proposed model SMAD2 SMAD4 IL36A PMC7758911__F1 RTKs and ERA36 in the development of tamoxifen resistance EGFR MTOR CCL2 PMC9424771__F8 Molecular mechanism of Epimedium in the treatment of vascular dementia based on network pharmacology and molecular docking JUN MMP14 SELE ITCH JUNB TRAF3 TNF FOS MME NOD2 CASP3 MMP3 HEL-S-11 TRAF1 CEBPB TRAF2 FADD PMC6462522__F9 BIN1 loss enables ATM activation by the nuclear protein E2F1 BIN1 ATM MDC1 PMC6116613__F3 MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE OPA1 FGF21 ATF4 PMC11859690__F2 Action of anti-HER2 drugs APC PTEN MTOR PMC11860879__F1 Signaling pathways in the immune TME in AOC STAT3 CD80 MAK CXCL2 TNF TRAF2 PMC11860879__F2 Multiple signaling pathways in the non-immune TME in AOC ATR EGFR GSK3B ATM GRB2 MTOR SHE ATP7B CTNNB1 ATP7A MEF2D PMC4136812__F4 Insulin, CCAAT/Enhancer-Binding Proteins and Lactate Regulate the Human 11Beta-Hydroxysteroid Dehydrogenase Type 2 Gene Expression in Colon Cancer Cell Lines HDAC1 AEBP1 IGF1 HEL-S-133P HSD11B2 GRB2 MTOR IRS1 PMC7903415__F1 The signaling pathways in LF by lncRNAs CTNNB1 PMC11860879__F4 Applications of NPs to reverse the non-immune TME in AOC NPS BRCA1 MEF2D PMC3733544__F7 FA/BRCA DNA damage response pathway BRIP1 BRCA1 USP1 BRCA2 PALB2 UBE2T PMC9321592__F6 IL‐20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis MAX VIP ITCH CXCL1 NPY CCL2 PMC9197867__F2 Osteoprotegerin and RANKL-RANK-OPG-TRAIL signalling axis in heart failure and other cardiovascular diseases VEGFB COX1 PI3 VEGFA PMC408106__F1 Partial synthesis pathway of GSLs HEXB PMC11880705__F5 Applications of live attenuated influenza a virus with modified NS1 gene TLR3 IRF3 IRF7 TLR7 PMC4541706__F1 The unfolded protein response ATF4 EIF2A XBP1 PMC8507154__F2 Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches FYN GDNF SRC RET PMC4671996__F4 Transcription factors and genes that regulate PDKs regulation HEL-S-133P PDC MTOR MYC PMC4853752__F1 MicroRNA network that is involved in regulating myogenesis SMAD1 SP1 SMAD2 MYF5 SMAD4 EZH2 MTOR YY1 PAX7 DEK FGFR1 RYBP CCND1 PMC4671996__F2 Illustration of Warburg effect in cancer cells FH HEL-S-133P PDC PMC7775721__F2 Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease TREM2 HEXB HEXA SMPD1 GLB1 PMC9099719__F2 Tumour Stem Cells in Breast Cancer CXCL12 CIC SELL HIF1A IL6 CCL2 ATG5 PMC12112599__F7 Images of the protein processing in the endoplasmic reticulum pathways enriched among the imported differentially expressed genes (DEGs) identified from the lipopolysaccharide (LPS) vs UFD1L SVIP BAX SEC63 SELL CASP12 ELF2 PAG1 SKP1 ATF4 WFS1 SEC62 PMC7775721__F1 Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease NPC2 HEXB HEXA NPC1 SMPD1 GLB1 PMC9099719__F1 Tumour Stem Cells in Breast Cancer MTOR CTNNB1 PMC6059371__F1 Function of Hsp70 in suppressing apoptosis after ischemic stroke BAX CASP9 CASP8 CASP3 FADD PMC4987408__F3 Regulation of rhein on the crosstalk of MAPK signaling pathway TG KDR NLK PMC10895590__F6 Immunorecognition of RNA/DNA fiber NANPs via the cGAS-STING signaling pathway can be regulated through functionalization with aptamers TBK1 CGAS IRF3 PMC4839494__F2 Adenosine receptor-mediated signaling pathways ADORA2A ADORA2B IL6 PMC6412520__F1 Simplified diagram of methionine metabolism (adapted from ) HEL-S-61p PMC5924476__F1 Mutations in CYB561 Causing a Novel Orthostatic Hypotension Syndrome TH PNMT DBH CYB561 PMC1602337__F9 TWEAK-Fn14 signaling system may play a role in stroke pathophysiology TRAF5 TRAF1 TRAF3 TRAF2 PMC6315862__F2 Overview of the DSB repair mechanisms RAD52 PMC12199384__F1 Core‐shell manganese phosphate nanomodulator enhances anti‐tumor immunotherapy via bidirectional reprogramming of the tumor microenvironment CD44 HMGB1 ADA PMC4749490__F1 Hypothesis: central neuroendocrine and peripheral mechanisms in generation of sex bias in PH PAH BCL6 PMC8944072__F3 Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease CDC42 TRO PARVA EGFR MX1 SET PMC7352357__F1 Cholesterol metabolism and key oncogenic pathways related to cancer development PCSK9 STAT3 ACAT1 NLRP3 HMGCR SQLE LDLR SMO PTEN INSIG1 PMC9001073__F6 Isoflurane Attenuates Cerebral Ischaemia–Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice NLRP3 TLR4 IL1B MYD88 PMC6199630__F6 Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis BAX RAD50 MRE11A BRCA1 ATM MDM2 MDC1 PMC3973632__F5 Integrated Analysis of Copy Number Variation and Genome-Wide Expression Profiling in Colorectal Cancer Tissues DBF4 CDC20 CDK7 PCNA CDC45 CDC6 SMAD4 CDK2 MDM2 MYT1 ORC3 SKP2 PMC11670821__F1 Generation and release of exosomes in response to bacterial infection AGO2 CD9 TSG101 CD63 PMC11670821__F3 Immune responses mediated by (H) pylori OMVs and infected cell exosomes CD40 CD81 TLR4 CD63 MYD88 PMC11670821__F5 Roles of H. pylori OMVs and infected cell exosomes in the extra-gastric diseases STAT3 NLRP12 CDX2 KLF2 VCAM1 PMC6016889__F1 CLL main pathogenic pathways and target agents against BTK, PI3K and Bcl-2 ROR1 CD40 SYK CXCL12 ROR2 CD19 MTOR ARHA BTK BCR PLCG2 LYN CXCR4 NOTCH1 PMC5366100__F2 Regulation of NOX by H NAPA DUOXA2 NOXA1 DUOX2 RAC1 NDP PMC8579447__F8 PiRNA-63049 inhibits bone formation through Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 AIP LRP6 WNT2B CTNNB1 PMC6571165__F1 Signaling pathways that modulate cardioprotection in CMs CITED4 BAX CYR61 PTEN ARHA PMC6571165__F2 Signaling pathways that contribute to CF activation and stress response ADRBK1 HDAC1 BRD4 EGFR ARHA PMC3345255__F1 MAPK/ERK signaling and the hallmarks of cancers BAX EGF BAD MTOR TNF PMC12084948__F2 Signaling networks downstream of SLAMF receptors in regulating immune cells DOK1 SLAMF7 SYK C2 VAV1 SRC PMC3926884__F1 Identification of a KRAS mutation in a patient with non-small cell lung cancer treated with chemoradiotherapy and panitumumab EGFR IL4 GRB2 AREG MTOR SHE KRAS PMC2958210__F12 Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout mice CA3 IPP CCK PC PMC12084948__F4 SLAMF receptors modulate cancer progression SLAMF7 SLAMF8 CCL2 PMC10506410__F3 Vitamin D receptor deficiency may induce alopecia through the Ddit4/mTOR signaling pathway NR1i1 TSC2 BMP1 DDIT4 PMC9468787__F1 Nexus of lipid and O-Glcnac metabolism in physiology and disease OGA OGT FAS XBP1 PMC10506410__F1 MTOR Signaling Network (A) Overview of the mTOR signaling pathway (B–D) mTORC1 signaling in mRNA translation, metabolism, and protein turnover (E) mTORC2 signaling function MTHFD2 EIF4B CAD EGFR ULK1 UVRAG GSK3B PTEN HIF1A EIF4E RHEB TSC2 TSC1 FOXO1 NF1 TFEB TBC1D7 ATF4 GRB2 SLC38A9 PMC8405566__F3 Candidate model for Ccr4-Not mediated nutrient signaling RRN3 ARF1 POLI CCR4 PMC7075943__F1 Predicted lipid synthesis pathways of phospholipids in E PGP PI3 PC PMC8178461__F1 Roles of PD-1/PD-L1 in the prognosis and immunotherapy of prostate cancer STAT3 LIF LRP11 PTEN CTNNB1 PMC7291472__F1 Diagram of CD155/CD112-mediated immunoregulatory pathway on NK cells CD96 CD226 TIGIT PMC8511527__F1 Endoplasmic Reticulum Quality Control in Immune Cells ATF4 EIF2A XBP1 TRAF2 PMC4032983__F6 CK1 in Wnt-signaling APC LRP5 LRP6 ARHA RHO SIPA1L1 CTNNB1 PMC4032983__F8 CK1 in Hippo signaling in vertebrates LATS1 LATS2 NF2 CTNNB1 PMC9315518__F10 Identification and Functional Analysis of Individual-Specific Subpathways in Lung Adenocarcinoma STAG2 DBF4 CDC20 PCNA CDC6 STAG1 ORC6 SMAD2 SMC3 SMAD4 CYC1 MYT1 SKP2 ORC2 CDX2 MCM7 CDK7 CDC45 MCM3 CDK2 HP MDM2 PMC6134416__F1 小细胞肺癌的的分子发病机制 BAX CDK2 CDK4 PMC12006098__F10 Galangin attenuated MPTP-induced brain tissue injury in PD model mice, and the related mechanism may be related to the PI3K/AKT signaling pathway TH MTOR BDNF PMC4107035__F2 PATHOGENETIC MECHANISMS OF FOCAL CORTICAL DYSPLASIA STRADA RHEB STAMBP TSC1 NF1 GRB2 MTOR EIF4E PMC6134416__F3 在SCLC中，受体酪氨酸激酶及其配体通常呈过表达状态。缺陷性受体酪氨酸激酶及它们各自的生长因子包括：VEGFR/VEGF, c-Kit/SCF, c-MET/HGF, FGFR/FGF以及IGF-1R/IGF。通过多种通路的激活，包括在SCLC中失调的PI3K/AKT/mTOR通路，在存活、凋亡、细胞周期调节和翻译过程中发挥作用。Receptor tyrosine kinases and their known ligands are often overexpressed in SCLC HGF PTEN IGF1R MTOR PMC8965611__F5 Signaling Pathways Associated With Breast Cancer Bone Metastasis JUN FGF20 LRP6 MTOR SRC TRAF6 MYC FGF18 CTNNB1 PMC4107035__F3 PATHOGENETIC MECHANISMS OF FOCAL CORTICAL DYSPLASIA STRADA RHEB STAMBP TSC1 NF1 PTEN GRB2 MTOR PMC2151841__F4 Signal transduction pathway in the UPR ELF2 ATF4 TRAF2 PMC5971224__F1 Fatty acid (FA) and ceramide synthetic pathway in autosomal recessive congenital ichthyosis converge on the corneocyte lipid envelope (CLE) ELOVL4 CERS3 TG DGAT2 ALOX12B LIPN PEX2 ALOXE3 ALDH3A2 PMC4319960__F7 SMAD-Independent Down-Regulation of Caveolin-1 by TGFB: Effects on Proliferation and Survival of Myofibroblasts SMAD2 PMC83966__F7 Ras effector pathways in NGF stimulated PC12 cells CDC42 NGF PI3 PMC7464644__F3 Role of Tumor-Associated Myeloid Cells in Breast Cancer STAT3 ARG1 MMP9 PMC7464644__F2 Role of Tumor-Associated Myeloid Cells in Breast Cancer SEMA4D STAT3 EGF CCL18 CSF1 ADM EGFR CXCL1 ARG1 EPHA4 PMC8489191__F1 Post-translational modification control of viral DNA sensors and innate immune signaling HEL-S-72p TBK1 CGAS MAVS TLR9 AIM2 IRF3 IFI16 CTNNB1 MYD88 HNRNPA2B1 MRE11A DHX36 DDX41 PMC12145212__F9 Mechanisms by which hypoxia impairs spermatogonial proliferation CDK6 CCND1 CDK4 PMC12029571__F4 UPR pathway ATF4 XBP1 TRAF2 PMC7155770__F4 Death receptor pathway of apoptosis SHARPIN RIPK3 TRADD MLKL RELB RIPK1 TRAF2 FADD PMC12029571__F1 Main metabolic pathways involved in cancer GLS CPT2 MYC PMC12029571__F2 Main metabolic pathways involved in cancer TG SCD FASN HEL-S-5 CPT2 PMC7155770__F3 Mitochondrial pathway of apoptosis HTRA2 APAF1 DIABLO PMC7906172__F9 ADSCs promote functional recovery after spinal cord injury by activating the TGFB1/Smad3/PLOD2 signaling pathway TGFBR2 SMAD2 SMAD4 PLOD2 TGFBR1 PMC5617400__F4 Autophagy-related gene expression is an independent prognostic indicator of glioma GATA2 PPARG RREB1 SH3GLB1 UVRAG ATG14 SH3RF1 IRF1 MAPK9 MAP3K11 MTOR MAPK8 ATG10 CTCF TCF3 ATG3 ATG12 E2F4 IRF2 FOXP2 FOXP3 ATG5 PMC9656839__F8 High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role RHEB TSC2 PGAM2 TSC1 IGF1R MTOR IRS1 PMC3132733__F1 Pathway-Based Association Analyses Identified TRAIL Pathway for Osteoporotic Fractures TRAF3 FADD PMC6477898__F4 Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease ABCG1 WAS CPT1A PMC9290759__F2 Association of Gut Microbiota and Treg Dysfunction in Autoimmune Diseases COX2 AHR PMC9701576__F3 Racial disparities in prostate cancer: A complex interplay between socioeconomic inequities and genomics TMPRSS2 FOXA1 RGS12 DBP MNX1 APC FASN PTEN ERG UBB CTNNB1 PMC9528914__F1 Polycystic Liver Disease: Pathophysiology, Diagnosis and Treatment APC BRAF PC PMC7541127__F4 Landscape of major pathway alterations in primary GBM EGFR BRAF PTEN CDKN2B RB1 MDM4 CDKN2A CDK6 CDKN2C NF1 PDGFRA MDM2 CDK4 PMC10705747__F6 CBD’s neuroprotective mechanism in ABeta-induced impairments GDNF SLAMF8 PLCG2 HEL-S-2a GRN BDNF CTSC PMC9495798__F9 Physiological and Comparative Transcriptome Analysis Reveals the Mechanism by Which Exogenous 24-Epibrassinolide Application Enhances Drought Resistance in Potato (Solanum tuberosum L.) BIN2 TH WAS PMC11281541__F10 Hypothetical schema of the protective role of MIN in TBEV-infected Vero cells RYR2 SYT11 EGFR SNAP25 PMC3821994__F1 PI3K/AKT/mTOR signaling pathway showing interacting activation and regulatory feedback loops RHEB EEF2K TSC2 RICTOR TSC1 EEF2 MTOR BDNF PMC3004523__F2 Hypothetical roles for LAB-dependent positive signaling SYK FYN IL3 KIT LYN GRB2 GAB2 PMC4841221__F1 Changes to coral health and metabolic activity under oxygen deprivation C6 HEL-S-62p C2 AIP PMC6481742__F1 Schematic representation of the major components of the endosomal pathway and the generation of exosomes CD81 HMFT1766 CD24 CD9 EGFR TSG101 CD63 EDIL3 PMC3975402__F2 Apoptosis pathway BAX BAD APAF1 FADD PMC5264260__F2 Intracellular signaling pathways of A7nAchR in anti-inflammatory response STAT3 HMGB1 TLR4 IRAK4 IL1B MYD88 PMC9472579__F1 Insights into pandemic respiratory viruses: manipulation of the antiviral interferon response by SARS-CoV-2 and influenza A virus TBK1 STAT1 CGAS TRIM25 TLR3 STAT2 IRF3 TLR7 ISG15 OAS1 PMC4576457__F7 Hypothalamic PKA regulates leptin sensitivity and adiposity STAT3 POMC SOCS3 PMC8509318__F2 Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NFKB Activation: A Review of the Molecular Mechanisms SIAH2 DUSP2 PMC9530862__F2 Effect of fasting on cancer: A narrative review of scientific evidence LAMP2 IGF1 MTOR SIRT1 PMC12024365__F8 Diagram of PPAR signaling pathway APOC3 SCD FABP4 PCK1 PMC9709415__F3 Protective effect of natural medicines against excessive inflammation and oxidative stress in acute lung injury by regulating the Nrf2 signaling pathway KEAP1 TLR4 NQO1 GSK3B IL1B MYD88 PMC2994272__F8 Carnosol in human prostate cancer PC3 cell line TSC2 TSC1 PTEN MTOR PMC5862044__F1 Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence TH HIF1A MTOR MYC PMC9709415__F1 Protective effect of natural medicines against excessive inflammation and oxidative stress in acute lung injury by regulating the Nrf2 signaling pathway KEAP1 MAF PMC7363928__F8 Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling HEL-S-133P TLR4 CXCL1 IL8RB PMC4631823__F1 Model for brassinosteroid (BR) signaling pathway in the absence and in the presence of BR IWS1 BIN2 BAK1 PMC4842059__F3 Id2 network model in insulin signaling, thermogenesis, and adipogenesis pathways NR1C1 ID2 BMP4 RXRA FASN PRDM16 LIPE UCP1 TWIST1 PMC10912430__F6 Signaling pathways that may be triggered by cellular autophagy during intestinal I/R NLRX1 TXNIP ULK1 FUNDC1 PMC10912430__F4 Signaling pathways that may be triggered by cellular pyroptosis during intestinal I/R RIPK3 NLRP3 TXNIP TLR4 EGFR RIPK1 PMC5337147__F2A Post-transcriptional regulation of cytokine and growth factor signaling in cancer CDH2 STAT3 EGF SKIL BAD TGFB1 HGF HMGA2 FRS2 ID2 CELF1 HEL-S-62p EGFR GSKIP TWIST2 MTOR VEGFA ARHA TGFBR1 TGFBR2 SMURF1 ELAVL1 C2 GRB2 PMC8478533__F3 Crosstalk between Heart Failure and Cognitive Impairment via hsa-miR-933/RELB/CCL21 Pathway NR2C2 CDC42 HEL164 AURKA ZNF143 FUS HEL113 BAD MAVS ETV3 TXNIP USF2 TLR9 ATP2A2 ACACA CPD UXT GNAS EREG TRIM28 CCL21 CRY2 ALOX12 ELANE MGMT CAD STAR AQP3 SELL PER1 SCD BPI CD14 SYMPK PURA ACTN4 MTF1 DBI SSPN PMC9437486__F6 Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway KEAP1 GPX4 SLC7A11 PMC10912430__F5 Signaling pathways that may be triggered by cellular ferroptosis during intestinal I/R GPX4 FACL4 TRPV1 TERT SLC7A11 PMC8880424__F6 Multi-Omic Analysis to Characterize Metabolic Adaptation of the E. coli Lipidome in Response to Environmental Stress PGP PSD C9 PMC8183045__F8 Site-directed mutagenesis of the quorum-sensing transcriptional regulator SinR affects the biosynthesis of menaquinone in Bacillus subtilis IPP MEN1 GIP PMC10912430__F3 Signaling pathways that may be triggered by cellular apoptosis and necrosis during intestinal I/R HDAC3 BAX SIRT3 FAS PKD1 PRDX3 PINK1 MAPK13 TRAF3 PIN1 PMC9434120__F1 Relationship between metabolic reprogramming and drug resistance in breast cancer TG GLS LAT F2 HEL-S-162eP FASN BCAT2 MYC PSPH PMC9434120__F2 Relationship between metabolic reprogramming and drug resistance in breast cancer ITGB1 MTOR CTNNB1 PMC7516048__F2 Model for B. pertussis CyaA regulated complex signaling pathways to block the monocyte differentiation and to trigger macrophage dedifferentiation LATS1 LATS2 ARHA PMC10912430__F1 Signaling pathways that may be triggered by cellular oxidation or inflammation during intestinal I/R BAX SIRT3 NR1C1 PRDX3 NQO1 TRAF3 SIRT6 PMC3078450__F5 Network annotation of genes differentially expressed according to the CD133 status in HT-29 using ingenuity pathway analyses BMI1 CDKN2A TNC PAXIP1 WNT3A IL13 APC FGFR1 FGFR3 CTNNB1 PMC9688046__F2 USP7 Inhibitors in Cancer Immunotherapy: Current Status and Perspective MDM2 FOXP3 PMC8065217__F1 Spatiotemporal regulation of hydrogen sulfide signaling in the kidney DAO PMC6443339__F12 Regulatory effects of H2S on PCSK9 expression and lipid metabolism PCSK9 LDLR ABCA1 PMC9317282__F12 Comparative Transcriptome and Interaction Protein Analysis Reveals the Mechanism of IbMPK3-Overexpressing Transgenic Sweet Potato Response to Low-Temperature Stress TF MYB ERF MYC PMC4125416__F2 Adaptive immunity with Toll-like receptors IRF7 MTOR TRAF6 EIF4E MYD88 PMC9146250__F3 New Insights into Hematopoietic Stem Cell Expansion to Stimulate Repopulation of the Adult Blood System for Transplantation BRPF1 AHR LYN MB MTOR THPO SRC CD34 PMC6450748__F10 Ethanol induces hyperacetylation and hyposuccinylation of mitochondrial proteins involved in diverse metabolic pathways ATP5F1D HEL-S-123m ACOT13 HEL-S-271 ATP5F1E ETFB OTC GPX1 GLUD1 ACAT1 ALDH2 ETFA SUCLA2 HEL-S-5 PRDX5 UQCRC2 PC NDUFB3 MDH2 CPT2 ETFDH ACSF2 GOT2 FH MPC2 SDHA DHRS4 DLD NDUFA2 NDUFS1 PMC8925223__F1 DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis HMGCR SC5D DHCR24 DHCR7 PMC10030580__F2 Macrophages in aseptic loosening: Characteristics, functions, and mechanisms LTA NLRP3 TAB3 MTOR TRAF6 IL1B MYD88 PMC4835794__F2 Hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns MAPK1 EIF4B STK11 CAB39 DDIT4 RPS6KB2 AKT3 PTEN HIF1A TNF IRS1 STRADA RHEB TSC2 TSC1 IGF1 PRKAA2 ULK2 PMC4835794__F3 Hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns MAPK1 EIF4B CAB39 AKT3 BRAF HIF1A PRKAA1 IRS1 STRADA RHEB TSC2 TSC1 IGF1 PDPK1 PMC8799702__F5 Protein tyrosine phosphatases in skeletal development and diseases BMPR2 STAT3 SMAD1 DKFZp781O1323 FRS2 SMAD2 GSK3B PTEN RUNX2 CTNNB1 MGP BMP2 PTH GRB2 PMC4981357__F7 Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity STAT3 UBA2 SAE1 PMC11748936__F7 SIGLEC11 promotes M2 macrophage polarization through AKT–mTOR signaling and facilitates the progression of gastric cancer TGFB1 SIGLEC11 MTOR PMC8889706__F8 LOX-1 receptor ectopically expressed in the liver alleviates atherosclerosis by clearing Ox-LDL from the circulation ABCG8 ABCG5 LDLR PMC8496081__F5 Genetic and epigenetic associations of ANRIL with coronary artery disease and risk factors TAF1 TAF6 TAF9 TBP PMC6159521__F4 Schematic drawing of the asymmetric specificity of the EndoMS-dependent MMR system and asymmetric occurrence of replication errors GC PMC11430996__F4 Effect of anthocyanin on initiating apoptosis in human colon cancer line BAX BAD FAS PMC8606538__F1 Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets ABCG1 HMGCR SQLE LDLR SOAT1 RHO FDFT1 ABCA1 PMC6033520__F1 Hedgehog pathway in nonalcoholic fatty liver disease IL3 PC SMO PMC3137639__F5 Akt-RSK-S6-kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases WNK1 NDRG2 EPHA2 EIF4ENIF1 MEPCE STX12 SEMA4B GSK3B PFKFB2 FGFR2 SP100 AKT1S1 UBXN4 SGTA IWS1 TCF12 FRS2 NDRG3 GOLGA4 ARHGAP19 IRS1 TSC2 TCF3 RICTOR KIF21A TAF3 BRD2 CABL1 SVIL BAD OXR1 EGFR MTOR HEL-S-100n DNAJC2 LMO7 EDC3 ARHGEF12 RPS6 PANK2 LARP1 GTF3C1 GSK3A UBR4 FOXO3A CD2AP PDGFRA STX7 TBC1D4 PMC6714586__F1 Main signaling pathways implicated in VE-cadherin/VM-positive cells CAD NRP1 CCND1 PMC3976810__F2 Molecular pathways are altered due to modulation of signaling pathway in skin cancer BAX IL10 CASP8 PCNA CASP3 MPO PMC7816290__F10 Schematic summary demonstrating the molecular mechanism of anti-ALR McAb inhibiting the proliferation of U266 cells CDC2 STAT3 CCND1 PMC4516482__F7 The hypothetical mechanisms involved in fibronectin-induced P2X4R up-regulation in microglia LYN MDM2 EIF4E PMC7018659__F8 Possible mechanism underling periodontal inflammation-induced metastasis CXCL12 NLRP3 TLR4 CXCL5 CCL5 CCL2 IL1B PMC9068916__F7 SP1-mediated oncogenic mechanism in CRC progression SP1 KDM2A TUG1 PMC6706905__F7 Systemic diagram of the mechanism of S1PR1/STAT3 signaling pathway STAT3 S1PR1 MYC CCND1 PMC2700213__F1 Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians ASIP POMC TYRP1 SLC24A5 PMC8789654__F5 Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway HDAC1 IRAK1 MYD88 PMC8789654__F6 Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway EGFR CASP3 AREG SRC CCND1 PMC8789654__F4 Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway CYP1A2 FOXA1 PTPRO SP1 NLRP3 CASP3 SOCS3 ERG MTOR CYP3A4 PMC11012077__F2 Chemokine Fractalkine and Non-Obstructive Coronary Artery Disease—Is There a Link? CX3CR1 RELA CX3CL1 RELB VCAM1 PMC6015375__F6 Schematic demonstrating of [U‐13C]glucose to CAC and PPP, and protein expression levels in HBP OGA OGT PDC CS PMC9302585__F1 Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture CASR TRPV5 PTH TRPM6 PMC5313050__F3 Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol FAS ACOT4 CYP2C9 CPT2 PMC11930710__F2 Model illustrates how resistance to EGFR-targeted drugs develops due to the loss of PTEN expression, caused by impaired nuclear translocation of EGR1 in lung cancer cells: A EGR1 EGFR PTEN PMC2889681__F1 Neurotrophic and neuroprotective pathways targeted by lithium BAD GSK3B MARCKS BDNF CTNNB1 PMC7603631__F6 Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1A Signaling Pathways Mediated by the NAMPT-NAD Pathway SIRT3 NAMPT SIRT2 SIRT1 PMC8014352__F5 Potential pathway of IGFBP-1 in the present review PGR IGFBP1 PTEN MTOR SRC ZIC2 IRS1 NR2F1 PMC9234081__F6 Dietary cholesterol promotes growth and ecdysone signalling pathway by modulating cholesterol transport in swimming crabs (Portunus trituberculatus) ACOX1 FAS PMC8834563__F2 Enhanced Loss of Retinoic Acid Network Genes in Xenopus laevis Achieves a Tighter Signal Regulation NR1i1 CYP51A1 CYP2R1 DBP CYP24A1 EBP SQLE DHCR24 VIT CYP27B1 DHCR7 HSD17B7 TM7SF2 CYP27A1 PMC9220817__F1 Blood Cell-Derived Microvesicles in Hematological Diseases and beyond TF CD44 CD9 HEL-S-171mP CD14 CD19 MPO PMC8923803__F9 Identification of IL20RB as a Novel Prognostic and Therapeutic Biomarker in Clear Cell Renal Cell Carcinoma IL20RB IFNL2 IL10 IF1IB1 IF2B1 IFNLR1 IFNL3 EGFR LEPR JAK3 IL20RA IL10RA TNF IL24 RELA EP300 FOXP3 IL10RB PMC9097137__F2 Current Insights Into Oligodendrocyte Metabolism and Its Power to Sculpt the Myelin Landscape MBP OLIG2 HEL-S-44 PMC3314677__F9 Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress in Human Prostate Cancer Cells by n-butylidenephthalide BAX CASP8 GSK3B CASP3 CDK2 CCND1 TRAF2 PMC2657476__F1 ErbB Receptors in the Biology and Pathology of the Aerodigestive Tract STAT3 BAD EGFR BCL2 GRB2 SRC PMC5370034__F6 Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway BAX PCNA CDK2 PMC9476742__F4 Emerging therapeutic role of Prunella vulgaris in thyroid disease TRADD CASP3 CDC37 CYLD TRAF2 PMC5640159__F1 Overview of the role of CtIP in the cellular response to DSB damage ATR BRCA1 CDK2 ATM PMC9313013__F1 Molecular Basis of Rare Diseases Associated to the Maturation of Mitochondrial [4Fe-4S]-Containing Proteins NFU1 FDX2 FDXR FXN BOLA3 LIAS GRPEL1 ISCA1 GRPEL2 PMC4118498__F1 Clinical Reasoning: A 20-year-old woman with rapidly progressive weakness HMBS AIP MB PMC6245662__F6 Monoamine Oxidase Isoenzymes: Genes, Functions and Targets for Behavior and Cancer Therapy NRP1 VEGFA TWIST1 MAOA PMC3136693__F1 Chemical heme biosynthesis pathway BOC CPO UROD UROS PMC7263378__F4 Synchronized redox regulation of cysteine residues throughout canonical EGF signaling pathways at 15 and 30 minutes CDCA2 RPS6 EGF PAIP1 BAD CAD TIMP1 EGFR APC ARF6 MTOR RHO CD55 CTNNB1 ELF4 MMP2 GRB2 SRC HEL-S-15 PMC5908849__F5 Metabolic and regulatory network of G TH HEL107 RPE LAT FRK ACD PMC7553623__F2 K-RAS pathway in cancer development EGF EGFR KRAS PMC4060285__F6 Schematic showing the protein acetylation sites in metabolic pathways that are most differentially acetylated in LDKO/flox liver MLYCD MCAT HEL60 ACSL3 ENO2 GYS2 ACADSB FACL4 CS ACSS2 PYGL OXSM HADHB SUCLG1 SUCLA2 ACADVL HEL-S-32 MDH2 GCK HEL-S-26 PKLR FH ACO2 HEL-S-133P HK2 ACADS FASN LDHB HEL-S-30 SDHA PGAM1 PGAM2 ALDOB OGDH PGM2 HEL-S-162eP HEL-S-49 FBP1 DLD ENO1 ACADL PFKL HEL-S-87p PMC6533081__F8 Proposed model of the regulation of erythropoiesis by heme and the HRI-ISR pathway during ID GRB10 ATF5 EPO ATF4 PMC9085237__F1 Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties HMGA2 AXL EGFR AXIN2 CTNNB1 CD44 TSC2 TSC1 CDK6 ABCC3 ATM WNT1 MDM2 SRC CCND1 NOTCH1 PMC4844615__F3 Pathogens-induced TLR signaling cascade in innate immune cells may exacerbate autoimmune diseases TIRAP IL16 TLR4 TRAF6 FOS IRAK4 MYD88 PMC11281666__F9 Deoxynivalenol and Its Acetylated Derivatives on Lipid Metabolism in Human Normal Hepatocytes GPCPD1 PNPLA6 LPCAT3 PEMT LYPLA1 PC PLAAT3 PLA2G4B PMC4471389__F1 Therapeutic potential of targeting IL-17-mediated pathway TH IL16 IL23R TYK2 PMC8359813__F1 Improving the Production of Riboflavin by Introducing a Mutant Ribulose 5-Phosphate 3-Epimerase Gene in Bacillus subtilis HEL107 RPE PMC3383194__F7 The mechanism through which PTPN22 blocks proapoptotic and enhances antiapoptotic BCR signals SYK PTPN22 BCR PLCG2 CD22 BLNK LYN PMC9599067__F3 Clusterin Transporter in the Pathogenesis of Alzheimer’s Disease at the Blood–Brain Barrier Interface: A Systematic Review RNF43 APC LRP5 ZNRF3 LRP6 GPR49 CTNNB1 LGR6 PMC3098994__F1 Genetics of Mechanosensation in the Heart NBR1 HEL-S-28 FHL1 PMC3953715__F1 PI3K/PTEN–mTOR pathway RHEB PTEN PMC8584958__F3 Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling UBC UBB PMC4022192__F5 TLR-induced signalling pathways TLR1 TIRAP TLR4 IRF3 IRF7 TLR7 MYD88 PMC4551270__F6 Genome sequence-derived metabolic reconstruction of Pyrobaculum yellowstonensis strain WP30 POR ALB FH HBD FADD PMC8942669__F3 Histone Methylation and Oxidative Stress in Cardiovascular Diseases SP1 KEAP1 COX2 TXNIP KDM5A EZH2 SUV39H1 PAX6 NOX4 PMC7132142__F7 Schematic representation depicting the role of KMO in MM (a) pDCs trigger growth, survival, and drug resistance in MM cells IDO1 KYNU KMO PDC HAAO PMC6156496__F4 Core interactions between the mTOR pathway and Alzheimer's disease MTHFD2 RHEB FOXO1 TFEB HIF1A ATF4 EIF4E PMC10948527__F2 SHP2 signaling pathways: SHP2-dependent signaling in both developing and established cancer cells is illustrated, with arrows denoting positive regulators and T-bars indicating negative regulators KSR1 GRB2 MTOR SRC CCND1 GAB2 IRS1 CTNNB1 PMC2955882__F4 ENaC and ASL volume regulation CFTR PMC5354077__F8 From big data to diagnosis and prognosis: gene expression signatures in liver hepatocellular carcinoma FAS MAL DAO PMC4686384__F5 Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins KLF2 AQP3 RAB31 FBXW11 FAF1 MORF4L1 RAB22A PABPC1 RAB5B PABPC4 FAF2 RPL15 TIEG2 FBXW7 FBXW2 BTRC RAB5A SLC25A44 KLF9 KLF5 PMC5036360__F9 CXCL3-induced signaling pathway in adipocytes FABP4 IL8RB CXCL3 PMC3484277__F1 Downstream signaling of the IGF-1R RHEB TSC2 IGF1 PTEN GRB2 MTOR IGF2 IRS1 PMC10948527__F4 Immune cell-specific roles of SHP2 CD226 CXCL9 ZAP70 IL10 CSF1 APC MTOR IRF8 CD47 IFNG TIGIT CD24 HOXA10 SIRPA ITK BTLA CSF1R PMC3484277__F2 Insulin like growth factor (IGF) and insulin receptor (IR) signaling system IGF2R IGF1 IGF1R MTOR IGF2 PMC8841479__F4 Narrative review for the Hippo-YAP pathway in cancer survival and immunity: the Yin-Yang dynamics LATS1 LATS2 RAF1 MDM2 PMC8841479__F1 Narrative review for the Hippo-YAP pathway in cancer survival and immunity: the Yin-Yang dynamics LATS1 NF2 AREG ITGAV PMC2635340__F2 Kinetic Scheme for the 5-HT1AR and 5-HT2AR mediated MAP kinase activation pathway PLAT APC PIR PMC4496485__F2 STAT3 signal transduction pathway STAT3 SOCS3 SRC TYK2 PMC5085760__F1 Major protein cascade and miRNAs in insulin signaling pathway MFN2 PMC11394629__F1 Genetics of BCC SUFU SHH SMO PMC11048531__F2 Combination of DSF/Cu and chemotherapeutic drugs sensitizes breast cancer (BC) cells and their stem cells by targeting various cellular and signaling mechanisms CD44 STAT3 BAX PGP CD24 FOXP3 PMC11394629__F2 Action of Hedgehog Pathway Inhibitors SUFU SHH SMO PMC3718700__F4 Presenilin functions PAN2 APP HEL-S-11 CCND1 CTNNB1 PMC9061914__F6 Exposure of primary osteoblasts to combined magnetic and electric fields induced spatiotemporal endochondral ossification characteristic gene- and protein expression profiles THBS1 TGFB1 HEL-S-133P HEL-S-7 CTSK COX5A HIF1A COL10A1 TGFBR1 SPP1 CTNNB1 VEGFB DCN PMC4995089__F4 Immune evasive attributes of SpA CD40 RIPK2 PMC3886260__F2 Lck is a central node in the T cell receptor signaling pathway CSK LCK PMC7935273__F8 GABA/Beta-glucan supplements on melatonin and serotonin content extracted from natural resources TIEG2 SP1 FOXO1 PMC6488418__F4 Figure 2.CD36 redox signaling in vascular smooth muscle cells, microvascular endothelial cells, and monocytes/macrophages SYK FYN KEAP1 CD36 HEL-S-2a PMC12034699__F6 Expression trends of each molecule associated with the interferon signaling pathway based on gene chip analysis The interferon signaling pathway was significantly activated SOCS1 IFNG BAX PSMB8 IRF9 PIAS1 IRF1 TYK2 PMC8707654__F6 Metabolomic Profiling of Blood-Derived Microvesicles in Breast Cancer Patients LPCAT2 PC PMC12042829__F1 Annexin A regulates regulated cell death patterns such as autophagy, ferroptosis, and pyroptosis NLRC4 STAT3 HMGB1 TFRC GSDMD NLRP3 AIM2 MTOR ATG5 PMC12164893__F1 Klotho protein-mediated network of signaling pathways FGF8A FGF21 FGF23 PF4 PMC11024688__F4 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of the PI3K-AKT (A, B) and mitogen-activated protein kinase (MAPK) (C, D) signaling pathway was mapped by fold changes MAX SYK EGF JUND BAD TRADD RBL2 PTEN TNF FLNA MEF2C IRS1 RHEB BCR RXRA MEI1 TRAF2 PMC6945546__F3 Future treatments for HHT BMP10 SMAD9 ENG SMAD1 DKFZp781O1323 PTEN ANGPT2 SRC PMC6945546__F1 Mutated genes in HHT encode members of the BMP9/BMP10 signaling pathway BMP10 BMPR2 ENG PMC4740301__F3 Monocyte genes associated with the ML ratio are enriched for genes in the interferon signalling pathway IFNG BAX IRF9 PIAS1 JAK1 TYK2 PMC8832734__F1 Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview GSK3B CTNNB1 PMC8832734__F2 Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview YBX1 TUG1 PMC6341270__F1 Mechanism of Nrf2 activation and Nrf2-mediated antioxidant responses in the lungs RBX1 KEAP1 MAF PMC4023363__F1 PI3K-AKT-mTOR signaling pathway and therapeutic opportunities RHEB FKBP5 TSC2 BAD EGR1 GRB10 ULK1 TFEB PTEN MTOR PMC5665033__F8 How arecoline affects glycolysis and the signaling pathway of anoikis in HA22T/VGH cells HK2 ARHA PMC10809359__F7 PPI network of the signalling molecules regulating macrophage activity and HIF-1 signalling pathways RPL8 RPS6 RPL35 TIMP1 CD177 IL4 ARG1 LDHB BLK RPS16 HMOX1 ITGAM MMP2 FES RPS12 PMC7668240__F3 Transcriptomic and Quantitative Proteomic Profiling Reveals Signaling Pathways Critical for Pancreatic Islet Maturation STXBP1 TRH CADM1 VAMP2 HEL-S-53e DHFR PFKFB2 PPM1E ACACA NCOA7 SYT7 SMARCE1 CLU GC CHEK2 AHR PKLR SMARCA4 CDK4 HSP90AB1 LPL HEL-S-72p CPLX2 APOE FASN SYT13 SNCA RAB3B RBL1 EFNB1 MCM7 PDE3B POLA1 PAK1 CDKN1B CACNA2D1 LIPE CDK2 FGA RRAS2 CP PMC4547013__F1 Network of miRNAs and target genes in OS STAT3 E2F3 DTL EGFR ROCK1 PTEN IGF1R ARHA MYC RUNX2 PMC7667664__F2 Efferocytosis in health and disease PPARG ADAM17 ADAM9 CD36 EPO ARHA TNF CD47 MERTK PMC5842195__F2 Cell cycle arrest signaling CDC2 CDK6 CDK2 CDK4 PMC7667664__F3 Efferocytosis in health and disease AXL COX2 RANBP9 CD47 PMC7667664__F1 Efferocytosis in health and disease SGK1 ELMO1 ADGRB1 PBX1 ABCA1 RAC1 MERTK PMC4317307__F7 Proposed models of adiponectin metabolic pathway and associated genes APPL1 COX2 ADIPOR1 ADIPOR2 IL18 IL4 PMC8148450__F5 Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways ATR JUN CAD LAT MAL BRAF CYC1 PTEN PMC3705163__F8 Schematic model indicating proposed mechanisms by which mutant p53 GOF induces EMT BMI1 KLF4 PMC9493169__F4 Bruton tyrosine kinase inhibitors in B-cell lymphoma: beyond the antitumour effect BTK NLRP3 TLR7 IL8RB CCL2 IL1B MYD88 PMC4074399__F1 Cell Death Pathways BAX TRADD APAF1 TRAF2 FADD PMC3713357__F1 Possible pathways for growth factor mediated tumorigenesis HEL-S-11 MTOR PMC5306231__F2 Possible cell-cycle checkpoint pathways in centrosomal (centriolar) integrity or morphology USP28 PLK4 NDEL1 PMC7312607__F7 Enriched pathway maps STAT3 JUN RHO FOS ADRBK1 IFNG FKBP4 SUMO1 GRIP1 NFKBIA PDE4D HDAC2 CEBPB UNK PMC5390895__F7 Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice RGS2 PRKD1 GAS PCSK2 CRTC2 RXFP4 HEL-S-28 FCGBP RXRG HEL-S-310 MAPK6 NR1C1 GPRC6A BCR TXN2 RPL10 FGFRL1 TIFA SESN2 SOX7 PMC4342024__F9 GPCR-mediated PLC/PKCB/PKD/SSH2 signaling pathway to regulate cofilin activity SSH2 PLCB2 PLCB3 PMC6721501__F2 Figure depicts pathways that cross-talk with Hh pathway leading to its non-canonical activation EGF EGFR GSK3B SMAD4 SMO MTOR CTNNB1 PMC2628375__F7 Hypothetical scheme of activation of the murine Hamp1 promoter STAT3 SMAD1 SMAD4 HFE2 PMC6721501__F1 Figure depicts canonical hedgehog signaling pathway SUFU GSK3B DHH SHH IHH SMO GLI3 PMC8664074__F1 Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma (HCC) initiation and progression KIF15 PRMT1 PCDH10 TRIM7 FOXR2 SIRT7 TRIM32 PRMT2 HPCAL1 DGIC NCAPG NEK2 FOXA3 TRIM44 TREM2 CXXC5 KIFC1 FOXP3 TRIM31 FOXK1 USP11 SIRT5 USP14 TRIM50 SIRT1 PMC7966997__F4 EGFR pathway (Biocarta) shown as an interacting network for samples with maximal (top) or minimal (bottom) PAL in colorectal cancer (left) vs normal colon (right) HRAS STAT3 PIK3CA EGF SOST MAP2K4 EGFR PRKCA GRB2 PRKCB PMC7721156__F3 Interaction of preimplantation factor with the global bovine endometrial transcriptome LTB SYK LTA BCR COX2 LAT ATM LYN TRAF6 LBP PMC5011655__F6 Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine PLN NOS2 PDE2A HTR5A BAD PLA2G1B AGTR1 HTR2A MMP9 PLA2G2A ADRA1B EDNRA TRPC6 PMC3276511__F2 Mass Homozygotes Accumulation in the NCI-60 Cancer Cell Lines As Compared to HapMap Trios, and Relation to Fragile Site Location CCL27 CXCR3 SYK CCL18 CCL15 CCR2 ROBO1 CCL2 CKLF DOCK2 CCL23 FYN RALA CCL21 IL16 CCR7 CCL7 CCR8 RALBP1 CCR1 MAPK1 CCL3L3 CCL16 LECT2 PLAUR HRAS CCL13 CCL8 CCL20 CCL22 CCR3 CTNNB1 ROBO2 NCAM1 SLIT2 CX3CR1 CCR6 SAA2 XCL2 CCR10 CCL17 ROBO3 CXCL13 CXCL16 RAC1 FGF2 CD44 CCL28 CCR4 ENPP2 LCK PF4 PMC7966997__F1 EGFR pathway (Qiagen Pathway Central) shown as an interacting network for samples with maximal (top) or minimal (bottom) PAL in colorectal cancer (left) vs normal colon (right) MAFK ME2 EGFR APOE RAG2 PMC7966997__F2 EGFR pathway (Biocarta) shown as an interacting network for samples with maximal (top) or minimal (bottom) PAL in colorectal cancer (left) vs normal colon (right) HRAS STAT3 PIK3CA EGF SOST MAP2K4 SHC1 EGFR PRKCA GRB2 PRKCB PMC7721156__F2 Interaction of preimplantation factor with the global bovine endometrial transcriptome TES MAFK MLKL NRAP CASP3 TNF FADD PMC9498798__F5 Gene Regulation during Carapacial Ridge Development of Mauremys reevesii: The Development of Carapacial Ridge, Ribs and Scutes BAMBI ADRBK1 EVC SOST INVS SPOP HHIP SUFU APC BCL2 SKP1 SMO PMC6613812__F1 PI3K/Akt pathway plays a central role in nutrient-mediated cell proliferation and growth RHEB TSC2 MAP4K3 TSC1 PTEN PMC2653092__F5 Basic Helix-Loop-Helix Factor Hand2 Regulates Autonomic Nervous System Development TH DBH PHOX2A HAND2 PHOX2B GATA3 PMC4754024__F1 Transcriptional regulation of IL-12p40 (IL12b) in antigen-presenting cells ETS2 TLR4 TLR9 IRF3 IRF8 MYD88 PMC7188049__F3 Role of ACE2 (angiotensin-converting enzyme 2) in the pathogenesis of coronavirus disease 2019 and the inflammatory response TMPRSS2 ATR ADAM17 ACE2 PMC9127157__F4 Emerging Roles and Therapeutic Implications of Epigenetic Modifications in Ovarian Cancer STAT3 NNMT MSC SOCS3 TRAF6 APAF1 CXCL14 PMC8964039__F2 Long Non-coding RNAs in the Development of Aging-Related Neurodegenerative Diseases GDNF APP BDNF PMC9127157__F5 Emerging Roles and Therapeutic Implications of Epigenetic Modifications in Ovarian Cancer IFNG BRCA1 CTNNB1 HOXA7 PMC4871813__F2 Schematic illustration of B-cell activating factor (BAFF) signaling pathway TRAF3 TRAF6 TRAF2 PMC8714130__F9 Tartary buckwheat flavonoids relieve the tendency of mammary fibrosis induced by HFD during pregnancy and lactation TNF IL1B MPO PMC3899188__F1 Regulation of lysosome biogenesis and functions in osteoclasts TCIRG1 SYT7 ATP6V1C1 PLEKHM1 CTSK TFEB OSTM1 RAB3D ATG5 GNPTAB SNX10 PMC7898550__F9 Schematic diagram describing the mechanism in the inhibitory effect of PQS on NR inflammatory injury NLRP3 PSD TLR4 MYD88 PMC3121598__F10 The interplay between leptin, IGF-1 and AB42 IGF1 EBP IGF1R IRS1 PMC12108893__F4 In malignant cells, the biosynthesis of fatty acids and cholesterol both use acetyl-CoA as the starting substrate ACLY FAS HMGCR CD36 FASN LDLR PMC10976710__F4 Molecular connection between the mTOR signaling pathway and polyploid giant cancer cells: (A) The interplay between polyploidy, senescence and mTOR signaling CD44 IL6 MTOR PMC8700172__F1 Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives CDH2 CCN4 EGF CYR61 IGF1R CCN3 TNF CTNNB1 CCN5 WISP3 BMP4 CTGF TWIST1 PMC6495097__F8 Model of the Action circSNX29 Competitively Sponging miR-744-Mediating Myoblasts Differentiation MYOG CDK2 NFATC1 CCND1 PMC5768893__F6 Schematic Representation of FGF4 Signaling Regulated by O-GlcNAc in ESCsPhosphorylated PKCζ, the active form, activates the MEK-ERK1/2 pathway by FGF4 stimulation OGT FGF7A GATA6 PMC9184702__F6 Effect of D-Met supplementation on the milk protein synthesis pathway PI3 HEL-S-162eP EIF4A2 MTOR PMC10931919__F1 Origins and intracellular sensors of self-nucleic acids promoting the IFN-I signaling pathway TBK1 CGAS TLR3 IFNAR2 IRF9 IFNAR1 TLR9 TLR7 JAK1 TYK2 PMC8692837__F3 Mechanobiological Implications of Cancer Progression in Space EPHB2 EPHB3 APC LRP5 LRP6 TCF4 LEF1 CTNNB1 PMC4028364__F1 Conservation of host cells and pathogen categories in zebrafish and mammalian infection by eukaryotes TNF CXCL8 IL1B PMC8891017__F7 Genetic associations of protein-coding variants in human disease TF F5 APC PMC2927928__F3 Molecular pathways involved in pancreas and liver differentiation from hES cells ALB NKX6-1 PDX1 SOX9 AFP PTF1A FOXA2 FGF10 FGF2 PMC4813275__F1 Pathways that represent potential targets for miRNAs in drug-resistant GC IHH BCL2 SMO PTEN IGF1R IRS1 PMC8145743__F8 CDDO-Me Attenuates Astroglial Autophagy via Nrf2-, ERK1/2-SP1- and Src-CK2-PTEN-PI3K/AKT-Mediated Signaling Pathways in the Hippocampus of Chronic Epilepsy Rats SP1 GSK3B PTEN PMC8395072__F3 Transcriptomic Analysis Reveals Key Genes Involved in Oil and Linoleic Acid Biosynthesis during Artemisia sphaerocephala Seed Development LPA DAG1 HEL-S-5 PC PMC3937033__F8 T cell PPI Network mapped to TCR, with main JAK-STAT and MAPK signaling pathways ICOS FYN LAT EGFR RELA ARHA REL LCK PMC3960190__F1 Perspectives of TGFB inhibition in pancreatic and hepatocellular carcinomas SMAD2 SMAD6 TGFBR3 SMAD4 GRB2 MTOR PMC2871322__F1 Schematic of central regulation of body fluid regulation in response to acute changes in sodium and volume NTS LPO AVP PMC12098375__F1 Regulatory mechanism of ERK1/2 signaling in promoting insulin secretion and insulin resistance EGF GRB2 IRS1 PMC2871322__F3 Schematic diagram of the forebrain neurocircuitry and peripheral inputs underlying the influences of osmotic and peripheral angiotensin II (Ang II) on sympathetic outflow and the baroreflex NTS LPO AVP PMC4554827__F1 Core of the Hippo pathway LATS1 HEL-S-31 MOB1A MOBKL1A BIRC5 LATS2 AMOTL2 AREG PMC6963216__F2 Cascade of events that leads to interferons (IFN) mediated antiviral response TBK1 STAT1 MAVS STAT2 IRF9 IFNAR1 IRF1 IRF3 JAK1 TYK2 PMC6456803__F1 Vitamin D pathway NR1i1 TH DBP CYP24A1 DHCR7 PTH CYP27A1 CUBN FGF23 PMC11790448__F1 Adropin regulates multiple signaling pathways LPL STAT3 PDK4 PTEN ARHA GPR19 BDNF GPX1 SIRT1 PMC4554827__F3 Function of nuclear and cytoplasmic Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding domain (TAZ) CDC73 NCOA6 CTNNB1 PMC4470732__F1 Scheme illustrating the ASARM-model and the FAM20C kinase link to the FAP pathway: The numbers highlighted in the circles refer to the explanations in the following text GALNT3 FAM20C DMP1 FURIN FGF23 PMC4554827__F4 Signal crosstalk with Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding domain (TAZ) LATS1 LAMA5 EGF NRG1 LATS2 DKK1 SMAD2 ZYX TBX5 AREG NOTCH2 CTNNB1 PMC8804851__F8 Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway ACAN NQO1 COL2A1 PMC2898451__F8 Schematic illustration of signaling pathways involved in PDGF-mediated induction of Arc expression EGR1 ARC PMC3426114__F9 Two Possible Models Regarding the Role of CDT1 Proteins in Response to DNA Stress.(A) Downregulation of CDT1 upon DNA stress may be promoted by WEE1 and/or SOG1 ATR WEE1 ATM CDT1 PMC7105474__F3 Life, death, and autophagy in cancer: NFKB turns up everywhere RELA RELB TRAF2 PMC3813433__F1 Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management RICTOR C2 MTOR PMC3475760__F1 As a key downstream target of PI3K-mediated signaling pathway in response to extracellular stimuli such as growth factors through receptor tyrosine kinase (RTK), Akt plays an important role in regulation of diverse cellular processes PTEN MDM2 PMC12121814__F10 Multifaceted roles of the small EV proteome in NP cell and tissue homeostasis HEL107 LDHB HEL-S-87p PMC8199608__F1 Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor CDC42 CD44 CDK5 ARHA PMC10759449__F8 Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway BAX PDIA4 PMC7913382__F5 Mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) pathway crosstalk, downstream effects, and inhibitors currently being trialled in pancreatic cancer treatment STAT3 EGF EGFR GRB2 KRAS PMC7913382__F6 PI3K/AKT/mTOR pathway in pancreatic cancer is central for cancer cell growth, survival, migration, invasion, angiogenesis, and modulation of the anti-cancer immune response RHEB STAT3 TSC2 TSC1 PTEN GRB2 TRIB3 PMC10932453__F2 Non-coding RNAs in the host response to M JUN MAP3K1 FOXO3A SOCS5 PTEN PPM1B KRAS FOS PMC10932453__F3 Immune response of the tracheal mucosa to M CCL13 IFNG TLR4 APC STAT4 PMC8508814__F1 Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy TF STAT3 CA9 PMC7690676__F2 Competing endogenous RNA (ceRNA) mechanisms and potential downstream regulatory mechanisms of NNT-AS1 BCL9 CDK6 MMP21 CCND1 CTNNB1 PMC3847144__F1 Isoprenoid and amino acid biosynthetic pathways IPP MVP MVK PMC3161420__F1 Regulation of apoptosis by the BCL-2 family BAX BAD FAS BMF PMC3355940__F2 K63-linked polyubiquitination in the activation of canonical and non-canonical NFKB signaling pathway CD40 IRAK1 TNF CYLD TRAF2 PMC4683180__F2 Tentative metabolic pathway model of membrane-bound electron transport in Methanoperedens CYB FH FES MTR PMC3340361__F1 RAB-7 Antagonizes LET-23 EGFR Signaling during Vulva Development in Caenorhabditis elegans EGF CBL EGFR GRB2 PMC4716037__F1 Deregulation of Hippo pathway in gastric cancer LATS1 LATS2 TEAD2 TEAD3 VGLL4 YAP1 TEAD4 PMC4832581__F2 Cellular iron homeostasis and putative involvement of NBIA‐associated genes WDR45 DCAF17 PANK2 FTL FA2H PLA2G6 C19orf12 CP COASY PMC9019922__F5 DSPP signalling during dentineogenesis and dentine regeneration TF SMAD1 DSPP BMP1 DKFZp781O1323 SMAD4 PMC7184741__F6 Glyoxylic acid overcomes 1-MCP-induced blockage of fruit ripening in Pyrus communis L. var. ‘D’Anjou’ FAS GLA MTR PMC4806539__F2 Biological networks according to IPA of 1370 genes related to HNSCC BRCA1 NFKB1 NFKBIA PMC6176484__F4 Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer GSK3B SHH LRP6 SMO CTNNB1 PMC6326357__F1 Role of MAIT cells in spondyloarthritis (SpA) HEL-S-92n RORC CXCR6 MR1 CD69 APC CCR6 CCR2 IL7R IL23R PMC6176484__F2 Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer MDM4 CDK6 MDM2 CDK4 PMC11809324__F7 Treg cell aging and regulatory role of PD‐1 in advanced‐age pregnancies DUSP4 PMC9326111__F6 Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer BAX BAD TRPV1 MCU TRPV6 PMC5722594__F1 Soluble PD-1 and PD-L1: predictive and prognostic significance in cancer ZAP70 SYK BCR PMC5366313__F5 Representative view of the iNKT/innate CD8(+) T-cell axis hypothesis in chronic myeloid leukemia (CML) IL18 RHO CD1D PMC7286881__F10 Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics REN LEP CFD TTN KIT LCK PMC10672974__F13 Recent Advances in Drug Discovery for Triple-Negative Breast Cancer Treatment PTEN MTOR IRS1 PMC7286881__F14 Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics TF LTA TGFBI LEP ADRA1A CCL2 PLAT MTTP INSR NPC1L1 TLR4 F10 IL18 THBD NPY KDR KCNMA1 PROC LPL VWF NOS2 THBS1 LEPR CD40LG PTGS2 TNF HEL-S-78p NPPA CHRM2 TFPI RELA RXRA APOB BCL2 PLTP PF4 PMC6603234__F3 Outline of potential mechanism of sEH inhibition-stabilized EETs in inhibiting colonic adenoma—carcinoma sequence via targeting inflammation and its activated Wnt/mutant p53 signals DIO1 COX2 APC KRAS PMC5057284__F3 Circadian oscillations in intracellular organelle’s structure and function XPA FIS1 PER2 PER1 ULK1 CRY1 NAMPT ATM ATF4 XBP1 PMC8186902__F4 HIF-1 signaling pathway with overlay data from differential expression and reporter metabolites analysis IFNG MAFK HEL-S-133P TLR4 HEL-S-162eP EPO PFKL HEL-S-87p PMC7765462__F10 Scenarios of SK3-Orai1 interplay ORAI1 STIM1 SIGMAR1 PMC5650067__F9 Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells EGFR SRC PMC4805359__F4 Schematic representation of the proposed model to explain NHR-49/PPARA function in promoting the longevity of germline-less animals (modified from Ratnappan et al.,) NR1C1 KRI1 TCERG1 PMC8350166__F1 PD-1/PD-L1 Axis as a Potential Therapeutic Target for Multiple Sclerosis: A T Cell Perspective STAT3 APC PTEN MTOR PMC6902900__F2 Overview of cellular metabolism in T cells TSC2 FAS TSC1 FOXO1 FOXO3A CTLA4 FOXP3 GCK CPT2 MYC DEPTOR PMC8616823__F2 Cell communication involved in tumour establishment, invasion and immune escape CHI3L1 GPR34 TLR9 CLEC2D AHR CCL2 TNF CR1 PMC7369235__F8 Signaling mechanisms of BCR-induced CSR CD40 SYK BTK BCR PLCG2 RELB TRAF3 TRAF2 AID PMC10907606__F8 Hypothetical model showing the role of OAT in IPF pathogenesis SMAD2 SMAD4 PRODH PMC4887650__F1 TLR4 intracellular signaling pathways TLR4 TAB3 MAL IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC4182113__F1 Interferons: Success in anti-viral immunotherapy STAT1 IFNAR2 IFNAR1 JAK1 TYK2 PMC7157451__F2 IFNA and IFNB bind to the type I IFN receptor (IFNAR) and activate the expression of numerous ISGs via the JAK/STAT pathway ISG20 STAT1 ADAR STAT2 IRF9 IFIT1 IRF3 IRF7 JAK1 TYK2 PMC3841209__F9 Off-label use of cetuximab plus sorafenib and panitumumab plus regorafenib to personalize therapy for a patient with V600E BRAF-mutant metastatic colon cancer ARAF EGFR BRAF KRAS PMC6263145__F2 Mitochondrial Quality Control in the Diabetic Heart ATG101 ATG12 ULK1 MTOR PMC6679985__F3 Circadian Clocks and Cancer: Time-Keeping Governs Cellular Metabolism MLX MYC PMC4849272__F3 Hepcidin antagonists TF ERFE STAT3 TFR2 SOSTDC1 SMAD4 HFE HFE2 PMC12174671__F3 Simplified visualization of NAD+ production pathways NAPRT HEL-S-90n NMNAT1 NAMPT NMNAT2 NMNAT3 PMC3710659__F9 The proposed signaling pathways for 8-iso-PGF2Alpha-mediated modulation of human platelet function TPR ARHA RHO PMC5511860__F6 BMP-2 induced EMT and breast cancer stemness through Rb and CD44 signaling CD44 SMAD1 BMP2 PMC5479927__F1 CoQ biosynthesis and effect of 4-HB analogs TH COQ7 IPP ALDH3A1 COQ3 COQ2 COQ6 COQ5 PMC3945521__F7 TRIMmunity: The roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity ECSIT TBK1 TLR3 TAB3 DDX41 TRAF3 IRF8 IFNA1 PMC3022513__F1 Physiological regulation of the mTOR signaling pathway RHEB TSC2 PTEN MTOR CTNNB1 EIF4E PMC8324684__F3 Metabolic-associated fatty liver disease and lipoprotein metabolism TG MTTP TM6SF2 APOB PMC10886332__F3 Co-expression network for the PP group based on lncRNA key regulators COMP NOCT PMC7906148__F4 Analysis of 219 hub genes with degree ≥10 SOCS1 TNC EFNB2 MYB FOSB HEL-S-7a NCF2 DLL4 CTSK PTGS2 EFNA1 NCF1 IRS1 WNT7A BMP2 CFTR SEMA3B PMC8869528__F1 Insights into the Role of Gremlin-1, a Bone Morphogenic Protein Antagonist, in Cancer Initiation and Progression SMAD1 DKFZp781O1323 SMAD6 SMAD4 PMC10467107__F7 Cardiac Toxicity Induced by Long-Term Environmental Levels of MC-LR Exposure in Mice TF TGFBI MTOR PMC9646898__F4 Identification of a TNF-TNFR-like system in malaria vectors (Anopheles stephensi) likely to influence Plasmodium resistance TRAF4 JUN ADAM17 TRADD TRAF1 TRAF3 TRAF2 FOS FADD PMC8145841__F2 Enigmatic Evolutionary History of Porphobilinogen Deaminase in Eukaryotic Phototrophs CPOX FECH UROD UROS PMC2757699__F1 Metabolic fate of the 13C-label from [1-13C]-glucose FAS HK2 PMC5288170__F1 Molecular mechanisms of OLIG2 transcription factor in brain cancer OLIG2 ARHA FGF2 FGFR2 TCF3 CDK6 PTCH2 PTCH1 SHH SMO MDM2 OLIG1 CDK4 PMC5067332__F1 Inositol mechanisms of action in cancer cells EGF ROCK2 ROCK1 INS PMC5676473__F1 Schematic diagram of Nrf2 signaling and regulation in the corneal epithelial cells KEAP1 NQO1 NOX4 PMC3831179__F15 Pathway Commons (accessed through Cytoscape) SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 SKI PMC3012148__F2 Biosynthetic pathway of sphingolipids that mediate expressions of genes associated with cellular processes in cancer BAX CERK TXNIP EGFR STIM1 PTEN CS FGF7A GFAP ZNF580 LEFTY1 CCND1 CDK4 PMC6798356__F2 COPD creates a favourable microenvironment for lung cancer initiation and progression S100A4 TNF SET PMC3562183__F2 Expression Microarray Meta-Analysis Identifies Genes Associated with Ras/MAPK and Related Pathways in Progression of Muscle-Invasive Bladder Transition Cell Carcinoma CAV2 VEGFC FAS VAV3 NCK1 AKT3 BRAF ARHA SKP2 FYN NF1 CDK2 GRB2 JAK1 PMC4055784__F2 The interactome space of the edible plants associated to colon cancer ACHE RAN GRAP PMC5528323__F6 Pathways of steroid hormone synthesis, metabolism and tissue sensitivity to HRT (Kelemen et al., 2008; Pasqualini and Chetrite, 2005; Masson et al., 2010) MiRNA's predicted to target steroidogenic or metabolizing enzymes are encased in blue CYP1A2 CRYZ CYP17A1 CDC20 PGR EGFR CYP1B1 CCNE2 CCNE1 HEL-S-130P HSD17B1 SULF1 ERBB2 CYP3A4 PMC4774640__F3 Schematic representation of the ectoenzymes and transporters involved in the extracellular ATP metabolism CFTR ENPP1 PMC11347096__F5 Schematic diagram summarizes the regulation of lipid metabolism in normal or malignant B cells UGCG BTK BCR SPHK2 CARD11 FASN SPHK1 PTEN SRC MYC MYD88 PMC3035871__F2 Targeting Fas in osteoresorptive disorders EPHB4 SYK SMAD1 JUN BMP2 LRP5 SMAD4 NFATC1 ATF4 ARHA RUNX2 FOS PMC11347096__F6 Schematic diagram summarizes the potential therapeutic targets of different lipid species and related pathways to treat inflammatory disease or B cell malignancy HDAC1 UGCG BTK FAS BCR SPHK2 SPHK1 MTOR MYC HDAC2 PMC11347096__F3 Cholesterol metabolism is necessary to defend against foreign antigens SYK ABCG1 BTK HMGCR BCR IFITM3 CD19 MTOR SRC ABCA1 MYD88 PMC11347096__F4 Sphingolipid metabolism CERK SMS tmp_locus_29 PMC11347096__F2 Phospholipids and their binding proteins mediate normal or malignant B cell activation SYK BTK BCL10 BCR CARD11 CD19 PTEN SRC PMC4859980__F1 HSV modulates apoptosis signaling CASP9 CASP8 TRADD LAT CASP3 TNF FADD PMC2909319__F9 Model: a Src-Tks5-Nck signalling pathway in invadopodia PI3 GRB2 SRC PMC3104012__F1 Summary of the common pathways underlying neurodegenerative diseases and cancer that are mediated by miRNAs DNMT3B BRMS1 MCL1 BACE1 PTEN MYC BCL2L2 CDK6 PITX3 CASP3 ATM APP NAV3 PMC6025008__F4 ER stress and the UPR in insulin resistance and diabetes VLDLR ATF4 IL6 EIF2A XBP1 IAPP PMC5380946__F1 TRIM38-mediated negative regulation of TLR3/4-mediated and TNF/IL-1-triggered signaling TBK1 TRIM38 TAB3 TANK IRAK1 IRF3 IL6 TRAF3 TNF TRAF6 MYD88 MEX3B TLR3 TLR4 IL1B PMC5940409__F7 Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells STAT3 IGF1 ATM CCND1 PMC3831179__F14 Pathway databases STAT3 EGF JUN GRB2 FOS PMC5380946__F2 Sumoylation promotes the stability of cGas and Sting and regulates the kinetics of the response to a DNA virus TRIM38 IRF3 SENP2 PMC1573858__F1 AT1 receptor signal transduction pathways that result in transcriptional NA neuromodulation (a) and increased firing rate (b) in neuronal cultures TH JUN FRK DBH FOS PMC10178434__F2 D+ synthesis pathways NAPRT NMNAT1 NAMPT NMNAT2 NMNAT3 PMC10607347__F3 The anti-apoptotic action of MSCs in the hepatocyte–MSC co-cultures BAX HGF PIM1 HK2 MSC PTEN MTOR PMC4961213__F3 IFN-induced Guanylate Binding Proteins in Inflammasome Activation and Host Defense GBP3 CAP2 GBP5 STAT1 GSDMD STAT2 IRF9 IL18 AIM2 IRF1 GBP2 PMC8101356__F6 Core transcriptional networks in Williams syndrome: IGF1-PI3K-AKT-mTOR, MAPK and actin signaling at the synapse echo autism CDC42 ALPI LTA MAVS CR2 NUMB TCF4 BCL2L11 ITGAX CHD3 UBA3 IGF1 NPPA RELA LAT2 KAT2B PMC4407539__F8 Predicted model of the immune response of Epinephelus coioides larvae to V MASP1 C6 C7 HEL-S-62p C2 C1S C4B_2 PMC8101356__F5 Core transcriptional networks in Williams syndrome: IGF1-PI3K-AKT-mTOR, MAPK and actin signaling at the synapse echo autism CDC42 EPHB4 VASP ARHG SSH2 MAL PTPRC CCR3 PTEN MAP2 RHO SET GIT2 ARHGAP26 ITSN2 HEL32 DBN1 PSD SSH3 SSH1 WAS PMC3982149__F6 Antibody against CD44s Inhibits Pancreatic Tumor Initiation and Post-Radiation Recurrence in Mice STAT3 H4C9 SOX2 CCND1 PMC7048745__F2 Ubiquitination in tumor metabolism regulation PTEN USP37 MTOR SENP7 SKP2 TRAF6 FBXW7 USP36 TRIM28 TRIM24 USP4 FBXL12 TTC3 OTUD7B TBC1D7 MDM2 CYLD HERC1 KLHL22 DEPTOR IRS1 VHL WWP1 RHEB OTUD3 MLST8 TSC2 RICTOR SENP1 NPRL2 PIAS1 RNF152 TRAF2 PMC7048745__F3 Ubiquitination in immunological tumor microenvironment (TME) modulation TBK1 TRIM38 CGAS TRIM32 TRIM56 MAVS ITCH DTX4 TANK TLR9 TRAF3 TRAF6 PELI1 MYD88 RNF125 MIB2 TLR8 AMFR TLR7 USP21 RNF5 MIB1 IRF3 IRF7 MAP3K7IP1 TRIM25 TLR3 TRIM23 PMC9106713__F1 Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway DLAT FES FDX1 ATP7B SLC31A1 PMC9468207__F6 Meta-analysis highlights the key drought responsive genes in genes: PEPC and TaSAG7 are hubs response networks ENG REN tmp_locus_29 SI PMC8999052__F6 Wide-Proteome Analysis to Identify Molecular Pathways Involved in Kidney Response to High-Fat Diet in Mice PYGL GCSH RPSA HEL-S-102 pcap SSR4 MAP2K1 MAP2 SET YWHAG PMC7032688__F5 Wolbachia limits pathogen infections through induction of host innate immune responses TRAF2 FADD PMC10674663__F7 Comparative Analysis of Cd Uptake and Tolerance in Two Mangrove Species (Avicennia marina and Rhizophora stylosa) with Distinct Apoplast Barriers MYB HP PMC7739442__F1 Inborn errors of immunity conferring predisposition to childhood HSE TBK1 STAT1 TLR3 STAT2 IRF9 DBR1 IRF3 TRAF3 JAK1 TYK2 PMC11742494__F7 CHI3L1’s role in the pathology of Alzheimer’s disease through modulation of neuroinflammation CHI3L1 STAT3 TNF PMC7158159__F6 Detailed signaling pathway of G-protein coupled receptor STAT3 FYN SRC GRK4 PMC7046483__F3 RANK/RANKL/OPG pathway in fatty acids‐modulated bone metabolism JUN SRC TRAF6 RUNX2 PMC7483535__F7 Long-term Changes in the Central Amygdala Proteome in Rats with a History of Chronic Cocaine Self-administration ARAF CRK BAD MOS NFATC1 SRC DOCK1 EIF4E PMC4369651__F1 Methotrexate pathway DHFR GGH TYMS SLC19A1 HEL-S-70p FPGS PMC7483535__F8 Long-term Changes in the Central Amygdala Proteome in Rats with a History of Chronic Cocaine Self-administration DRD2 DRD5 CALY DDC PMC3260552__F4 Melanoma signaling networks, progression, and influences by the BCL-2 family BAX BAD MCL1 PTEN BMF PMC4143829__F1 Model expressing the distinct molecular pathways of ER transcription factors regulatory actions TF EGFR SRC PMC7607069__F9 TP53 signaling pathway via cBioPortal MDM4 CDKN2A MDM2 PMC11742494__F2 CHI3L1-induced tumor angiogenesis, growth, migration, invasion, and inflammation CHI3L1 CD44 SMAD2 MMP9 CXCL8 IL13RA2 PMC6789471__F4 Protein–protein interaction (PPI) network of the set of DEGs/DEPs identified in the overrepresented GO Immune System Process terms DACT2 CSA2 PYCARD RNF4 PIK3R2 BRAF MYC HEL-S-99n MLL2 TOB2 PRKCA CACNB3 PSMD4 AP2S1 JUN PSMB3 RNF31 MAFB NCF4 PSMD7 ACTR2 TRIM25 TNFSF11 CDC37 WIPF2 FADD PMC7769847__F2 Schematic summary of Osx’s mission in the complex communications among different bone cells and its potential role in bone micro-environment SOST COL1A1 DMP1 AIP NFATC1 MMP9 PMC4358097__F11 Plasma treatment abolish siRNA-induced knockdown of NRF2 HMOX1 JUN JUND BACH1 CSF2 KEAP1 NQO1 PMC7769847__F3 Overview of crosstalk pathways associated with Osx GRP SOST COL1A1 LRP5 LRP6 ZBTB16 DLX5 RUNX2 ENPP1 MSX2 PMC3675380__F2 Synergy between TCR/CD28 and TNFR signalosomes for activation of the PI3K-Akt pathway in T cells CD80 BCL10 APC GSK3B PMC9027994__F1 Proline Metabolism in Malignant Gliomas: A Systematic Literature Review PRODH PYCR2 PMC8697421__F3 Type I IFN immunity in viral pneumonia TBK1 STAT1 UNC93B1 TLR3 STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IRF7 TRAF3 PMC8697421__F1 Inborn errors of immunity underlying severe cutaneous HPV infections ARHH ZAP70 DOCK8 CD80 LAT CARD11 PIK3CD PIK3R1 STK4 IKBKG HEL-S-92n MAGT1 CARMIL2 WAS ITK CXCR4 LCK PMC3509894__F3 Vitamin B12 Synthesis and Salvage Pathways Were Acquired by Horizontal Gene Transfer to the Thermotogales CBL APP PMC3675380__F1 Tumor necrosis factor receptor family molecules that possibly activate the PI3K-Akt pathway in T cells LTA CD27 TNLG8A TRAF5 TRAF1 TRAF3 TNF TRAF2 PMC10834974__F5 Novel preliminary metabolomic panel for IHD diagnostics and pathogenesis C6 HEL-S-62p C2 PMC6980368__F2 S1P signaling in HCC progression MMP7 S1PR1 SPNS2 HGF TRAF2 PMC9340492__F1 Zebrafish models of inflammation in hematopoietic development and disease IFNG GATA2 TBK1 SYK FLI1 RUNX1 IRF9 LYN IL6 JAK1 IL1B PMC7996784__F2 Mevalonate and methylerythritol 4-phosphate pathways in Cannabis sativa IPP ME2 MVD PMC9359975__F6 Extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1A signaling pathway ZEB2 TWIST1 PMC8827057__F8 Overview diagram describing the mechanism of the inhibitory effect of HF-MSCs on HSCs SMAD2 SMAD4 PMC6945783__F1 Scheme of the functional patterns within the glycolytic pathway in beta cells in health and type 1 diabetes HEL-S-133P GCK PMC6791856__F8 Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation HMGB1 NLRP3 PMC5552660__F1 Cholinergic anti-inflammatory pathway (CAP) NTS TNF PMC8636596__F3 Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway TBK1 MAVS IRF3 PMC8469138__F4A Molecular Biology Networks and Key Gene Regulators for Inflammatory Biomarkers Shared by Breast Cancer Development: Multi-Omics Systems Analysis CD2 IL2RB TCAP CPB2 CFI CFP C4BPA C8A TTN PLTP MYC CD3G PMC6411824__F1 Overview of the Nrf2 pathway activation RBX1 KEAP1 RXRA MAF RAC3 PMC8827057__F1 Experimental design ALB AFP SMAD2 PMC5414761__F8 Proposed mechanism for GDNF-induced proliferation of mesenchymal and epithelial cells in the UGS GDNF RET PMC2886808__F1 Signalling through growth factor receptors can activate the PI3K/Akt/mTOR pathway and the JAK3/STAT5 pathway JAK3 FOXP3 MTOR PMC9949995__F2 Transgenerational epigenetic inheritance of axonal regeneration after spinal cord injury FOLR1 DHFR PMC6904864__F1 Small molecules guiding mesenchymal stem cell osteogenic cell fate determination SMAD1 IGF1 CTNNB1 PMC5941175__F4 Kinetic reaction schemes of GroEL–GroES interaction revealed by HS-AFM imaging under different substrate conditions FH FBL SI PMC9009033__F3 ARID1A variations in colorectal cancer: a collaborative review ARID1A AURKA PIK3CA FBXW7 ARID1B APC ARID2 MTOR PLK1 KRAS ARID4A PMC4546755__F1 Known regulatory mechanisms of NRF2, highlighting miRNA-mediated influences CDKN1A KEAP1 NQO1 AHR PMC4546755__F2 Overview of ROS-mediated NRF2 activities TXN KEAP1 NQO1 PMC4546755__F3 Overview of carcinogenesis and NRF2 responses KEAP1 PMC8020867__F1 Map of net odds () for reactions of glycolysis and the tricarboxylic acid (TCA) cycle RPE GOPC PMC7443379__F8 Molecular and cellular basis of left–right asymmetry in vertebrates FOXH1 LEFTY1 SMAD2 LEFTY2 DRAP1 NODAL GDF1 PITX2 PMC8371750__F7 Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study CASP9 FAS CDK6 CASP3 PMC8997421__F1 MicroRNAs and Progesterone Receptor Signaling in Endometriosis Pathophysiology AGO4 AGO1 AGO2 DROSHA PMC2996483__F3 Oncogenic Notch1 Signalling IL7R PTEN MTOR PMC6720712__F7 Diagram illustrating the underlying mechanism by which that miR-15a regulates the differentiation of chicken intramuscular preadipocytes by targeting ACOX1, SCP2 and ACAA1 in the PPAR signaling pathway ACOX1 PMC7556779__F5 Evasion of the Pattern Recognition Receptor-Type I Interferon (PRR-IFN-I) Pathways by Coronaviruses (CoVs).A simplified schematic of the canonical IFN response after sensing RNA viruses TBK1 STAT1 CGAS MAVS STAT2 IFNAR2 IFNAR1 IRF3 IRF7 JAK1 TYK2 PMC9681554__F9 Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury GSDMD NLRP3 ARG1 PMC7617722__F3 Fatty acid metabolism and its regulation by E5, E6 and E7 encoded by HPV oncoproteins ACLY FAS EGFR FASN HEL-S-5 PMC3711381__F1 ERK pathway, its upstream activators and downstream targets EGF RAF1 EGFR BDNF PMC3711381__F3 Htt affects ERK signaling in multiple ways EGF BDNF HTT PMC8891382__F2 Tumor Immune Microenvironment and Immunotherapy in Brain Metastasis From Non-Small Cell Lung Cancer EGF CD80 HGF CCL21 CX3CL1 MMP2 PTEN MMP9 MTOR TNF IL1B PMC9370344__F10 Waterlogging Stress Induces Antioxidant Defense Responses, Aerenchyma Formation and Alters Metabolisms of Banana Plants ERF PDC ACCS PMC6044347__F2 The steroidogenic pathway CYP17A1 CYP11A1 LDLR PMC9077970__F4 Dual role of autophagy in acute myeloid leukemia FASN TFEB MTOR PMC11357512__F2 Signalling pathway in a cardiomyocyte with lamin A/C variant factors such as pERK1/2, pSmad1/2, and TEAD1 affect the gene expression of LMNA mutant cells RYR2 CAMK2D PMC9077970__F1 Dual role of autophagy in acute myeloid leukemia DRAM2 ATG5 PMC9077970__F2 Dual role of autophagy in acute myeloid leukemia WWP1 FLT3 STAT3 ULK1 TFEB PML ATF4 MYC HEL-S-26 ATG5 SIRT1 RET PMC2849704__F1 Homocysteine metabolism in liver and kidney HEL-S-61p PMC6548405__F7 CBX2 is required to stabilize the testis pathway by repressing Wnt signaling CBX2 SOX9 LEF1 PMC7042394__F1 Core components of the Hippo pathway in Drosophila and mammalian LATS1 MOB2 PMC4987730__F7 Antibody-mediated blockade of the PS signaling pathway in the tumor microenvironment CD300A TYRO3 PMC4460803__F2 Recently identified drivers in signaling pathways involved in adrenal tumorigenesis CYP21A2 STAR ARMC5 ZNRF3 LRP6 PMC5538796__F1 Endothelial cell metabolism in health and disease: impact of hypoxia PROX1 FAS CPT1A PMC11005695__S1 Thermosensitive Bi‐Adjuvant Hydrogel Triggers Epitope Spreading to Promote the Anti‐Tumor Efficacy of Frameshift Neoantigens TBK1 CGAS NHS IRF3 IRF7 TLR7 TRAF6 PMC5791813__F1 Interplay between Nrf2 and Brf2 pathways KEAP1 PMC3773983__F2 Four major signaling pathways in the postsynaptic region of a neuron that combine to form a local signaling network MAPK1 GRB2 BDNF PMC10804064__F2 Comprehensive Review of the Key Characteristics of the Genus Mentha, Natural Compounds and Biotechnological Approaches for the Production of Secondary Metabolites IPP PMVK MVK PMC7573470__F1 Life cycle of SARS-CoV-2 and its possible inhibitors TMPRSS2 HEL-S-69p ACE2 PMC7168252__F1 Beclin 1 function in autophagy and the role of its post-translational modifications implicated in cancer ATG101 BCR ULK1 EGFR UVRAG ATG14 PMC2649086__F7 KLF14-mediated TGFBRII silencing SIN3A SP1 KLF14 PMC4803136__F1 The biologically relevant candidate genes selected in this pharmacogenomic study ADORA2A MTHFD1 DHFR SHMT1 IL2 EEF1A1 GGH TYMS SLC19A1 HEL-S-70p FPGS PMC11202552__F2 Simplified diagram of the insulin signaling pathway PDE3B FAS FOXO1 RAC1 PMC4957599__F2 Molecular mechanism of disc cell senescence ATR CDK6 CDK2 ATM MTOR CDK4 PMC4880142__F6 Exposure of MCF-7 cells to 10 nM E2 (A) and 1 μM G-1 (B) induced phosphorylation of proteins involved in cellular processes associated with cell cycle although the specific phosphorylation profiles varied NDRG2 RAF1 NMT1 PAK4 MARCKS MYC KPNA2 ALK EBAG9 TPD52 G3BP2 NPM1 SRPK1 UNG ZNF217 GORASP2 AKT1S1 EAPP HNRNPK CAD PYGO2 YBX1 EIF5 MARK1 HEL-S-34 SEC31A BAG3 TRIM25 SUDS3 OGFR PARD6B DFFA SCRIB MAP2K2 PMC8718269__F4 Functions of PARP5a/b, PARP7, and PARP9 in viral infection TBK1 STAT1 AKT3 DTX3L IRF3 IRF7 EXOSC5 PARP1 PMC8492287__F6 Novel Identified Peptide Hormone “Metabolitin” Attenuates Lipid Absorption in the Small Intestine of Diabetic Mice with Nonalcoholic Fatty Liver Disease by Regulating Neurotensin and AMPK Signaling Pathway FAS NR1C1 CD36 PMC9932084__F10 Work model of 181-Rik function in the mitochondria-mediated inflammatory response of microglia UCP2 GSDMD NLRP3 STMP1 PMC3494185__F7 Hypothetical schematic of the roles of KPNA2 and E2F1 in NSCLC DBF4 KPNA2 JMJD6 POLA1 POLA2 PMS2 UGDH MCM10 PMC6880611__F1 Insulin signaling and insulin resistance in MetS and skin diseases TSC2 GRB2 PMC7248199__F7 Putative pathway showing regulatory relationships of key genes to NFKB activation transcriptionally regulated by NLRC5 STAT3 CASP8 LITAF TLR5 IL2 IRF7 TLR7 CCL5 IL5 GATA3 PMC7278913__F3 SMAD4 loss and potential therapeutic strategies in SMAD4 signaling HEL-S-68p SMAD4 PMC3380218__F1 The Drosophila IMD and mammalian TNF signalling pathways CASP8 TRADD RELA REL TRAF2 FADD PMC4430528__F5 Sharing and Specificity of Co-expression Networks across 35 Human Tissues ZAP70 LY9 SEMA4C LBH ITGB7 PZP GATA3 RUNX3 KCNA3 TIGIT IL2RB CCND2 CD9 NLRC3 FMNL3 GIPR LCK PMC4513088__F8 Proposed signaling pathways of PS1-induced apoptosis BAX CASP9 CASP3 BCL2 PSAP DIABLO FADD PMC7088895__F1 TGFB and BMPs signaling pathways SMAD9 SMAD1 DKFZp781O1323 SMAD2 SMAD4 MTOR PMC9942973__F9 Working model for HCMV-induced SOCS3 upregulation in NPCs LIF SOCS3 RFX7 PMC12206628__F6 Signaling pathways of NK cell-mediated cytotoxicity and apoptosis KIR2DL4 HMGB1 THBS1 KIR2DL1 MAVS GSK3B PTPN11 STK4 TNFRSF10A HAVCR2 PLCG1 PRF1 HLA-E FYN RFFL IFNAR2 PAK1 IFNAR1 STX4A MAP2K1 HLA-C HDAC2 PF4 PMC4862578__F1 Illustration of negative regulators of CaN-NFAT signaling pathway in cardiac hypertrophy CHP2 FHL2 CHP1 RCAN1 RCAN3 PMC8292061__F5 Exploring the Mechanism of Scutellaria baicalensis Georgi Efficacy against Oral Squamous Cell Carcinoma Based on Network Pharmacology and Molecular Docking Analysis CDC2 CDC42 FLT3 EGFR KIT TERT VEGFA ALK INSR F2 NR3A2 IKBKB MMP2 SRC PMC3697783__F8 Wnt signaling pathway RBX1 APC LRP5 SMAD4 LRP6 SKP1 NLK PROC CTNNB1 PMC7028010__F1 UPR activation mediates beta-cell survival STAT3 TXNIP ATF4 EIF2A XBP1 PMC6901278__F3 Regulatory network hubs are related to neurogenesis NPAS1 ID2 NPAS3 EGFR MIB1 APOE PTEN NOTCH2 WNT7B PLXNA4 RELN TBR1 SLIT3 SEMA3A PAFAH1B1 WNT7A CALB1 ADAM10 GAD2 LFNG CDH4 DNER NOTCH1 PMC5966770__F2 Biosynthesis and consumption of NAD+ PNP NMRK1 HEL-S-90n NAMPT NMRK2 PMC3278831__F4 Sample subnetwork formation ATM RHO MDM2 PMC7731343__F7 Differentially expressed protein (DEP) expression in the plasma of rainbow trout exposed to thermal stress HEL-S-62p HEL-S-78p PS1TP5BP1 PMC9141839__F7 Activation of Esterase D by FPD5 Inhibits Growth of A549 Lung Cancer Cells via JAB1/p53 Pathway CDC20 ESD CDCA8 PMC9547461__F2 Emerging role of pyroptosis in pediatric cancers: from mechanism to therapy BAX CASP8 TRADD MLKL DFNA5 TNF NLRC4 RIPK3 NLRP1 GSDMD ZBP1 TRAF5 RIPK1 APAF1 TRAF2 FADD PMC4818113__F6 Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways RHD NHS FES PMC4938759__F1 Mammalian target of rapamycin complex (mTOR) pathway modulates blood-testis barrier (BTB) function through F-actin organization and gap junction MLST8 MMP9 DEPTOR PMC12106265__F3 ER stress in DILI ATF4 XBP1 TRAF2 PMC7765045__F1 Main pharmacogenetic biomarkers associated with conventional synthetic disease-modifying antirheumatic drug (csDMARD) treatment NAT2 RFC1 DHFR SLC19A1 ABCG2 HEL-S-70p DHODH TPMT PMC9547461__F7 Emerging role of pyroptosis in pediatric cancers: from mechanism to therapy HMGB1 GSDMD GZMA GSDMB DFNA5 IL1B PMC7020065__F5 During pregnancy recognition (PR) in cattle conceptus produced IFNT increased expression of type I IFN-stimulated genes (ISGs) in the uterine endometrium and increased prostaglandin (PG) production facilitates these effects IFNGR1 PTGER2 PTGER3 OXTR STAT2 IFIH1 IRF3 IRF7 PTGS2 TRAF3 IFNG STAT1 TLR3 IFNAR2 PTGER1 IFNAR1 PTGS1 TLR8 TLR7 PTGER4 JAK1 PTGFR TYK2 PMC7693003__F2 Role of FDFT1 in the biosynthesis of cholesterol, structure and roles of lipid rafts and regulation of FDFT1 by SREBP2 HMGCR FDFT1 PMC3108467__F4 IFN signaling pathway coded with identified proteins on day 7 postinfection IFNG BAX PAICS IRF9 PIAS1 IRF1 IFI35 GBP1 TYMP PMC4274748__F4 Inactivating gene fusions of NF1 in lung cancer MYO15A DRG2 PSMD11 NF1 NLK PMC5381110__F6 Quantitative proteomics by SWATH-MS reveals sophisticated metabolic reprogramming in hepatocellular carcinoma tissues GLDC GCSH HEL-S-182mP PHGDH SHMT1 PMC7693003__F1 Biosynthesis of cholesterol and its derivatives CDC42 ARHA FDFT1 RAC1 PMC7219953__F1 Proposed mechanism of action underlying the fast and sustained antidepressant effects of ketamine GSK3B MTOR BDNF PMC2834833__F3 GSK3: a multifaceted kinase in Wnt signaling TSC2 LRP5 LRP6 CTNNB1 PMC8535772__F3 Glutathione in Mediating Abscisic Acid Signaling and Its Regulation of Seed Dormancy and Drought Tolerance ABI2 MOCOS SNRK PMC6064680__F1 Model cell illustrating the Gq-mER signaling pathway in hypothalamic neurons CAV3 POMC NPY PMC11749302__F3 Selected results of natural product-based nanomedicines against liver disease MPL GAL UBR5 HEL70 PMC8607235__F4 SOCS proteins and their roles in the development of glioblastoma STAT3 STAT1 EGF PHLPP1 TRIM24 GSK3B SOCS3 PMC7498629__F2 Role of FoxO signaling in activating ubiquitin-proteolysis and autophagy-lysosomal pathway when skeletal muscle is immobilized FIS1 IGF1 ULK1 MFN2 MUL1 MTOR SIRT1 PMC9464948__F6 Luteolin induces pyroptosis in HT-29 cells by activating the Caspase1/Gasdermin D signalling pathway GSDMD NLRP3 IL1B PMC11702054__F2 TRIB2 in the physiological proliferation of granulosa cells, myoblasts, naive T cells, and thymocytes, and pathological proliferation of VSMCs EGR1 TRIB2 MTOR RUNX3 PMC11702054__F3 TRIB2 in the lung cancer cell, liver cancer cell, and leukemia cell proliferation RFWD2 STAT3 BAX HMGA2 TRIB2 HEL-S-133P GPX4 EBP TCF4 CTNNB1 TRIM21 TFRC SMURF1 PBX3 HOXA9 MEIS1 CCND1 PMC8607235__F5 SOCS proteins and their roles in the development of glioblastoma EGF OSM SOCS3 GAB2 PMC2656900__F1 Working model for Eph receptor function in tumor promotion and tumor suppression EGFR ERBB2 ARHA PMC11702054__F5 TRIB2 in melanoma cell, colorectal cancer cell, ovarian cancer cell, and osteosarcoma cell proliferation TRIB2 TUG1 CTNNB1 PMC4919052__F6 Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq TF STAT3 IL10 LEP IL13 IRF1 IL17A IL5 MYC IFNG NR2A1 IRF2 NFE2L2 AHR PPARGC1A IFNB1 IL1B PMC4919052__F7 Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq PPARGC1B NR1C1 NR2A1 SREBF2 PPARGC1A NR1C2 XBP1 PMC4064697__F2 Schematic summary of the photoneuroendocrine control of food intake and body weight RARA TSHB TSHR CRABP2 PMC4686085__F4 Axon guidance pathway involving neuropilin 1 ROBO3 CDC42 TH DCC ROBO1 ARHA ROBO2 NEK1 SEMA3A FYN RAD1 RHOD FES CXCR4 SEMA7A PMC10136307__F4 Proposed ER-related mechanisms in the induction of autophagy and UPR in B cells TSC2 TSC1 ATG12 ULK1 UVRAG AMBRA1 BCL2 ATF4 EIF2A TRIB3 ATG5 XBP1 PMC8469138__F3A Molecular Biology Networks and Key Gene Regulators for Inflammatory Biomarkers Shared by Breast Cancer Development: Multi-Omics Systems Analysis CD226 CD3D CRTAM TCAP HEL-S-273 CD84 ACTN2 SH2D2A TPM1 PYGL RTP4 HRC TTN OASL ITK CYBA SIT1 CD2 TNNT3 IRF9 CXCL16 CTLA4 CD96 CD44 STAT4 CD3G CD3E LCK PMC10136307__F2 Inhibition and induction of autophagy ATG101 ATG10 ATG12 ULK1 UVRAG ATG5 PMC3675677__F1 Insulin-like growth factor type I (IGF-1R) signaling axis RHEB TSC2 GRB10 TSC1 PTEN IGF1R MTOR IRS1 PMC4407080__F1 Image of the MAPK signaling pathway painted by KPP according to the imported list of genes differentially expressed in the prostatic carcinoma as compared to normal prostate MAX MOK EED CD14 GRB2 PMC7487981__F1 Local area (subpathway) of retinol metabolism pathway is highly correlated with ALDH1A1 LRAT DHRS4 PNPLA4 UGT2B7 PMC3774847__F1 Schematic model of GMIP and Slp1/JFC1 regulation of vesicular dynamics and exocytosis in neutrophils RAB27A ARHA PMC7472693__F3 Coordinated regulation of the host NFKB pathway by L SHARPIN HEL-S-71 UBE2V2 MAP3K7IP1 TRAF6 PMC7025433__F1 Methionine metabolic pathway HEL-S-182mP HEL-S-61p MTR PMC10814159__F3 MDM2 and CDK4 pathway regulation CDKN2A MDM2 CDK4 PMC3386543__F7 Schematic of C/EBP A/B functions in GCs EGF STAR CYP11A1 NRP1 HEL-S-61p RUNX2 PMC10814159__F5 Activation of the Hh/GLI signaling pathway SUFU GSK3B BCL2 SMO CCND1 PMC4557273__F5 Sperm navigation along helical paths in 3D chemoattractant landscapes GC PMC9482985__F2 Transcriptional regulation of oil biosynthesis in seed plants: Current understanding, applications, and perspectives MED15 DGAT1 ENO1 PMC5681735__F1 Kynurenine pathway (KP) HEL-S-90n IDO1 IDO2 PMC6041131__F5 Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors SOCS1 DKK3 FFAR2 SFRP1 PMC5040710__F8 Illustration of role of differentially regulated proteins involved in different pathways in rice for sustaining during drought stress HEL-S-162eP CS GLO1 PMC9679345__F2 Gap Junction–Mediated Transport of Metabolites Between Stem Cells and Vascular Endothelial Cells MOG NOG MAL MEI1 MSC CD34 PMC7176421__F6 Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement FAS MTOR BDNF PMC9284435__F2 Ferroptosis: Opportunities and Challenges in Treating Endometrial Cancer FANCD2 TGFBI SLC7A11 ATF4 PMC150458__F3 Known Wnt signaling pathways APC HEL-S-11 ARHA CTNNB1 PMC5862315__F4 HFD activates genes involved in inflammation and tumorigenesis WNT10B HCAR2 KRT1 STAT3 NTS TGFB1 LEP FZD10 MED4 S100A8 KRT16 WNT10A ADCY8 HMOX1 BCL2L1 PLAT DUOXA1 FKBP1A ACKR3 MMP3 ADAM8 SRC MMP7 MED30 ACKR2 MMP10 LEPR PTPN1 MMP9 WNT7B GATA3 SPP1 HEL110 MMP20 WNT3 ADCY1 GJB6 S100A9 MMP28 SELP PMC6040091__F4 WNT/Beta-catenin signal transduction pathway APC LRP5 LRP6 CTNNB1 PMC3978512__F3 Canonical WNT/Beta-catenin signaling genes marked in green are hypermethylated in parous women (suggesting down-regulation of the gene in parous women) MMP7 APC HEL-S-28 TCF4 PIN1 SFRP1 CTNNB1 CD44 HDAC1 MAP3K7IP1 DKK1 NLK MDM2 SRC WIF1 PMC4087737__F1 A: The heme biosynthetic pathway FES ACD PMC4905365__F1 Targeting the lncRNA-dependent noncanonical Hedgehog pathway by LNA in combination with classical Hedgehog pathway inhibitors CCL21 SHH POLI SMO RHO CIT PMC6402450__EV2 Metabolic Reprogramming in Colon Cancer ACLY PRM2 PAICS HEL-S-133P FASN TIGAR PMC7915605__F6 Summary of steroidogenic pathways in primary trophoblast cells isolated from human term placenta CYP21A2 HSD17B3 CYP17A1 CYP11A1 HSD3B1 HSD11B2 HSD17B1 HSD11B1 PMC4128856__F7 Targeting c-Met in melanoma RHEB TSC2 HGF APC GATA6 MTOR PMC6014489__F1 The Wnt signaling pathway WNT10B DVL1 SMAD4 NR1C2 MYC APC2 BAMBI FRAT1 SOST DKK1 SOX1 PRKCA WNT1 CACYBP CCND3 GPC4 JUN NKD2 LRP6 NFATC1 ARHA DAAM2 AXIN2 RBX1 RUVBL1 FOSL1 SKP1 NLK WIF1 PMC3792350__F1 Overview of peroxisome biogenesis: converging de novo and growth and division models PEX19 PEX6 GET3 PEX3 PMC3808934__F1 RLR-mediated pathways of type I interferon and inflammatory responses TBK1 TRIM25 IRF3 IRF7 TRAF3 TRAF6 FADD PMC3808934__F2 Interplay of TLR and RLR signaling TBK1 TLR3 TLR4 TLR9 TLR8 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC8371477__F2 Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease WWTR1 ERBB4 FOXN4 BMP4 ERBB2 HAS2 PMC7322959__F3 Differentially expressed genes in SPCs of GATA2 deficiency ERAF NCAPG DERA HEL-S-11 UROS LMNA RHAG YWHAG PMC11002443__F6 Putrescine Upregulates Melanogenesis Through Modulation of MITF Transcription Factor in B16F1 Mouse Melanoma Cells MSRA MC1R PMC4037312__F3 PI3K/AKT/PTEN signaling, which modulate NOXs-derived ROS TSC2 TSC1 PTEN MTOR CTNNB1 PMC3760732__F8 Pathway interactions among HGF/c-Met, PI3K/Akt, and Notch signaling pathways HGF PTEN HES1 PMC7343183__F8 JNK pathway plays a key role in the immune system of the pea aphid and is regulated by microRNA-184 JUN YKT6 PRX FOS PMC9042933__F1 NRF2 Expression Under Different Conditions CDKN2A RBX1 KEAP1 NQO1 KRAS PMC4531138__F2 miRNAs control inflammatory response in ECs KLF4 KLF2 CXCL12 THBS1 SMAD2 CXCL1 RGS16 IRAK1 TRAF6 CCL2 TGFBR1 NR1C1 BTRC CXCR4 SIRT1 PMC5198544__F3 Tissue injected with B. asper venom TLR4 IL1A IL1B PMC11639970__F1 WNT and TGF-Beta Pathway Alterations in Early-Onset Colorectal Cancer Among Hispanic/Latino Populations JUN APC RHO GRB2 MTOR PMC8002238__F1 Cyclophosphamide metabolic pathway (adapted from Jonge et al., 2005 ) CYP2B6 CYP2C19 CYP2C9 CYP3A4 PMC3091413__F7 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways PLSCR1 MYBL2 GSK3B NRP1 CCNA2 SKP2 PSEN1 MAPK8 STUB1 FGFR2 VEGFB FBXW7 CCNE1 DLK2 TBP RALBP1 TDG SMARCA4 MAPK1 CASP9 RAD51 VEGFA NOTCH2 MAP3K1 BRCA1 MVP CDKN1B HSPA4 CDK2 CDKN1C CDK9 TGFB1 HEY2 ITCH NUMB VTN PTEN CCNH CKS1B HIPK2 CDK7 JAG2 NOTCH3 GPS2 HEL2 UBC CASP2 BAG1 RBL2 CHD3 FKBP5 RBL1 HDAC1 IKBKB CASP3 CREBBP EP300 UBE2I TRAF2 PMC3091413__F5 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways based on the Asian population RFC1 RAF1 HEY2 PCNA PXN GSK3B NUMB PTEN NCOA6 CCNA2 PSEN1 MYC SKP2 RB1 FBXW7 FYN COL1A1 MNAT1 JAG2 MDM2 NOTCH3 TBP NOTCH1 SMARCA4 MSH6 UBC MCC RBL2 NOTCH2 HDAC1 RBL1 CBL MAML1 IGF1 BRCA1 PRKDC CHEK1 CREBBP CDK2 EP300 CDK9 PMC3091413__F6 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways XPA ATR RFC1 PCNA NUMB PTEN CCNA2 SKP2 FANCA RB1 FBXW7 ATM MDM2 NOTCH3 CCND1 NOTCH1 MGMT SMARCA4 UBC CASP8 RAD51 MSH2 ERBB4 WRN NOTCH2 RPA1 TP53BP1 CDKN1A BRCA1 PRKDC CHEK1 CREBBP CDK2 EP300 PMC3091413__F4 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways based on the Caucasian population RFC1 RAF1 GSK3B CCNA2 MYC SKP2 MAPK8 RB1 FBXW7 CSTF1 MDM2 NOTCH1 SMARCA4 MSH6 MSH2 DLG4 GRIK1 E4F1 NOTCH2 BARD1 IGF1 ERCC5 CDK2 XPA ATR HEL113 HEY2 PCNA IKBKE NUMB PTEN BLM MAST2 CASP4 CHEK2 CHUK ATM NOTCH3 WRN RBL2 RPA1 CHD3 CD44 RBL1 HDAC1 MAML1 PRKDC CASP3 UBE2I TRAF2 PMC5620326__F4 Roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis STAT3 NOX4 RAC1 PMC8136131__F10 Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway TBX2 PPARG AEBP1 EGFR PIK3R1 DPYSL3 GPX3 COL3A1 MMP11 UCP2 TGFBR2 WT1 TLR4 GDF15 FGFR4 TBX3 EFNB2 EGFL6 APOE NBEAL2 ROR2 CLIP3 AGTR1 PDGFRL SDC1 ID1 ADRB2 GNA11 IGFBP7 MAP2K5 SRPX TWIST1 WFS1 FGF18 PF4 PMC5158012__F3 Triggering Receptor Expressed on Myeloid Cells and 5′Adenosine Monophosphate-activated Protein kinase in the Inflammatory Response: A Potential Therapeutic Target SYK TREM1 MPO MYD88 PMC5158012__F4 Triggering Receptor Expressed on Myeloid Cells and 5′Adenosine Monophosphate-activated Protein kinase in the Inflammatory Response: A Potential Therapeutic Target TREM2 SYK LAT PMC5099115__F3 IGF-1R Signaling IGF1 PTEN IGF1R PMC4906927__F2 Schematic of the RBPJ structure and domains demonstrating the domain organization of RBPJ, NICD and MAM BTD RBPJ PMC5580472__F1 Extrinsic and intrinsic apoptotic pathways CCS XK APAF1 TRAF2 FADD PMC3405333__F9 Pathway component for cell cycle G2/M DNA damage checkpoint regulation CD2 BRCA1 ARC PMC5283822__F2 Ubiquitin signaling during lesion recognition in the GG-NER pathway UFD1L OTUD4 USP51 DDB2 RBX1 DDB1 CUL4A CUL4B USP24 RNF111 XPC PMC5283822__F3 Ubiquitylation events during TC-NER UFD1L RBX1 DDB1 CUL4A NEDD4 UVSSA RBP1 INO80 PMC5329931__F2 Effects of TAMs on tumor progression CCL18 S100A8 PMC8275893__F2 TCF7L2 in Type 2 Diabetes CD44 APC GSK3B LRP5 LRP6 RYK PMC8275893__F3 TCF7L2 in Type 2 Diabetes APC GSK3B LRP5 LRP6 PMC4736120__F1 Approaches for xylose-based fatty alcohol production and improvement FAS MAL XDH CIT PMC8254604__F2 Key Signaling Pathways in Psoriasis: Recent Insights from Antipsoriatic Therapeutics STAT3 KEAP1 EBP AHR ATF1 TRAF6 IL23R TRAF2 PMC2947794__F1 Examination of Association to Autism of Common Genetic Variation in Genes Related to Dopamine TH DBH PAH DDC MAOA PMC9231384__F5 tiRNAs: Insights into Their Biogenesis, Functions, and Future Applications in Livestock Research FZD3 APC CCND1 CTNNB1 PMC7067536__F7 Hepatitis C Virus Infection of Human Thyrocytes: Metabolic, Hormonal, and Immunological Implications CSF1 FOXE1 USF2 HPS6 ZNHIT2 MARF1 OSBP2 RAB20 KNL1 HELZ DDIT3 TPO DHRS3 LHPP PMC9231384__F6 tiRNAs: Insights into Their Biogenesis, Functions, and Future Applications in Livestock Research NFKBIA CAPRIN1 PMC3293935__F4 Known apoptotic targets of P53 CASP9 PHLDA3 FAS PERP DDIT4 CASP3 PTEN PMC4370592__F6 Developmental Exposure to Estrogen Alters Differentiation and Epigenetic Programming in a Human Fetal Prostate Xenograft Model NKX3-1 CASP9 BAD CDKN1A PTEN PMC6945997__F3 Recognition of Candida species is mediated by Toll-like receptors (TLRs), C-type lectin receptors (CLRs) and nucleotide-binding oligomerization domain (NOD) receptors TH RAF1 NLRP3 BCL10 NOD2 IL1B CARD9 PMC11714729__F3 Hedgehog signaling pathway SUFU SHH SMO PMC11592846__F4 Lactic acid in macrophages during inflammation as a signaling molecule STAT3 SLC5A12 ARG1 MMP9 VEGFA SLC5A8 PMC5736922__F1 Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications GPRC6A NOX4 TRPM8 PMC8817698__F3 MAVS Immune Recognition Pathway in Viral Infection and Sepsis TBK1 MAVS IRF3 IRF7 PMC8817698__F4 MAVS Immune Recognition Pathway in Viral Infection and Sepsis NLRX1 MAVS OTUD1 PMC9701731__F1 Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination NF1 PDGFRA OLIG2 SOX10 BDNF OLIG1 PMC9617479__F1 Metabolic features of innate lymphoid cells ACLY ACAT1 GLS CS PMC4530265__F8 Proposed schematic showing targets of edible bird's nest (EBN) action in the insulin signaling pathway INSR IKBKB PRKCZ MTOR GCK PMC9617479__F2 Metabolic features of innate lymphoid cells ACLY ACAT1 MTOR MYC PMC4408865__F1 An example of positive and negative regulation of the Ifn-signalling pathway SOCS1 STAT2 IRF9 MAL IRF3 IRF8 TRAF6 TRIM21 MYD88 STAT1 TLR3 TLR4 TRIM8 JAK1 TYK2 PMC9617479__F3 Metabolic features of innate lymphoid cells FAS DGAT1 ARG1 MTOR PMC10740511__F4 Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer DTX1 DTX2 DTX3 DTX4 NUMB PSEN1 MAML3 CTBP1 JAG2 MFNG DLL3 HDAC2 MAML2 HES1 NOTCH1 HES5 DTX3L DVL2 NOTCH2 RBPJL NCOR2 PSEN2 DVL3 CREBBP EP300 SNW1 KAT2B KAT2A PMC10740511__F5 Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer DVL1 DTX2 DTX3 DTX4 NUMB PSEN1 CTBP2 DBX1 JAG2 MFNG NOTCH3 HDAC2 MAML2 NOTCH1 HES5 DTX3L DVL2 NOTCH2 RBPJL NCOR2 PSEN2 DVL3 CREBBP EP300 SNW1 KAT2B KAT2A PMC12135473__F2 Dual roles of AIF in cell death and in vital mitochondrial functions CHCHD4 NDUFS5 MIF PMC7761568__F2 Influence network of TCR signalling CD226 STAT3 CD80 LAT PRDM1 SMAD2 IL27 PTEN YY1 CTLA4 NFIL3 IFNG ICOS TIGIT MAF IL2 STAT4 FOXP3 GRB2 LAG3 PMC9583131__F2 Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice TLR3 CD14 IRF3 IL1B PMC6629960__F1 Air pollution and ultraviolet radiation (UVR) on the skin AHR PAH CYP1B1 CYP1A1 PMC9583131__F3 Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice IL16 AHR IL1B PMC5429641__F7 Neuroprotective action of MMP-9 in preventing ABeta-mediated impairment of the insulin survival pathway GSK3B BDNF IRS1 PMC5607574__F1 Schematic of Hh signal transduction in Drosophila and vertebrates KIF7 SUFU GLA SMO PMC8081860__F3 Lipoarabinomannan as a Point-of-Care Assay for Diagnosis of Tuberculosis: How Far Are We to Use It? LAMP3 RAB27A TIRAP LYN TNF MPO MYD88 PMC4564046__F1 Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution KEAP1 GCLM NQO1 GCLC MAF PMC8081860__F4 Lipoarabinomannan as a Point-of-Care Assay for Diagnosis of Tuberculosis: How Far Are We to Use It? ZAP70 LAT MTOR USP9X CD6 LCK CD3E MYD88 PMC7793839__F1 Toll-like receptor 4 (TLR4) signaling pathway TBK1 TLR4 IRAK1 IRF3 TRAF3 TRAF6 IRAK4 IL1B MYD88 PMC3274489__F1 Overview of the mevalonate pathway C6 C2 PMC3384380__F2 Schematic depiction of NFKB signaling pathway highlighting FOXP1 target genes CD40 ZAP70 EGF LTA LTBR TIRAP NFKB2 CARD11 GSK3B HDAC1 HEL-S-71 NGF PLCG2 HDAC2 TRAF2 LCK PMC6731300__F9 The proposed model PHLDA3 SRXN1 GPX1 PMC3374082__F7 Schematic representation of the data NR1C1 APOE IL6 NOTCH3 PMC5301050__F1 Cancer Therapies in HIV Cure Research IFNG CD80 PMC4146420__F1 Prostaglandin synthesis pathway ALOX5 COX1 ALOX15 ALOX12 PMC5137279__F4 Pictorial representation of altered GABA receptor signaling due to PCP-SI treatment ABAT GABARAP GPHN UBQLN1 SLC32A1 ALDH9A1 CP PMC7198750__F2 Depiction of the cGAS-STING pathway ULK1 ATM SLC19A1 TREX1 PMC11768203__F2 Virulence factors of Fusobacterium nucleatum TIGIT TLR4 CXCL1 TNF MYD88 BIRC3 PMC8122623__F2 Signaling Pathways in Bone Development and Their Related Skeletal Dysplasia SFRP4 SOST MAML1 ROR2 LRP5 MSC LRP6 PMC8122623__F3 Signaling Pathways in Bone Development and Their Related Skeletal Dysplasia MSC CNP GRB2 SKI PMC4783232__F1 MicroRNA deregulation in cancer cells and the tumor microenvironment KDM6B DGCR8 AGO2 EGFR MYC DROSHA PMC4959859__F8 Schematic mechanism of L5 on STRA6 cascade suppression and kidney injury HEL111 RBP4 PMC7959398__F7 Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection CD48 LAT CTLA4 TNF DAO ICOS CBL FYN BCL10 ITK GRB2 CD3E LCK CDK4 PMC4587406__F1 Dysregulation of dNTPs in cancer pathogenesis and its targeted therapy CDC2 ATR PMC11818720__F5 Carbohydrate metabolic pathway diagram PCK2 MME PKP3 PMC4287999__F4 Mechanism of T-helper-17 (Th17) cell-mediated lymphangiogenesis VEGFC IL18 IL1B PMC5843405__F3 SUMOylation in representative cancer pathways SMAD2 SMAD4 TNF TGFBR1 PMC9288288__F9 Network Pharmacology and Molecular Docking Study of Yupingfeng Powder in the Treatment of Allergic Diseases TH tal-1 STAR INA APP PMC7325056__F10 Intestinal microecological mechanism of diarrhea caused by Folium sennae extracts AOX1 AANAT ASMT DDC PMC10505224__F0 By hindering hnRNPA2B1 from binding to the E3 ubiquitin ligase TRIM21, whose mediated ubiquitin-dependent degradation was thereby inhibited, CRNDE protected the stability of hnRNPA2B1’s high protein expression in CRC HNRNPA2B1 KRAS TRIM21 PMC7286818__F2 Emerging roles of WBP2 oncogene in human cancers JUN WNT3A APC GSK3B AXIN2 HOMER3 CTNNB1 LATS1 WBP2 LATS2 AXIN1 ENO1 TNIK PMC10540449__F3 BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications KLF4 SMAD9 SMAD1 DKFZp781O1323 BMPR1A APC GSK3B SMAD4 IBSP CTNNB1 DSPP ACVR1 DKK1 PMC10540449__F4 BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications MKI67 SMAD9 SMAD1 HEL113 DKFZp781O1323 BMPR1A APC SMAD6 SMAD4 SHH UNG CTNNB1 PMC10540449__F1 BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications SMAD9 SMAD1 MAP3K7IP1 DKFZp781O1323 SMAD6 SMAD4 ATF2 PMC6547588__F1 Spatial regulation of non-amyloidogenic and amyloidogenic processing of APP VAMP2 VAMP3 CD2AP PSEN2 ARF6 BACE1 BIN1 APP ADAM10 GGA1 PSEN1 PICALM PMC7011106__F2 Gene-gene interaction among genes associated with atypical antipsychotic-induced lipid disturbances LEP DRD2 ADRA2A POMC MC4R CNR1 NPY AgRP BDNF PMC5310915__F12 Analysis of long noncoding RNA and mRNA using RNA sequencing during the differentiation of intramuscular preadipocytes in chicken LPL UBC UCP1 HEL-S-28 PLTP PMC8786307__F2 Inflammasome-independent signalling by NLR proteins in the intestinal epithelium during CRC STAT3 NAIP NLRP12 NLRX1 NLRC3 AIM2 MTOR PMC9482771__F6 Target genes implicate in inflammation process potentially altered by miR-378 PRMT1 HEL-S-103 BMP8B CAB39 ABL2 CACNG8 RPS6KA2 BRAF GNG12 STK4 NODAL MYC E2F5 FLNA RPS6KA6 FGF8A DUSP3 TGFBR2 MAP2K6 CCNG2 NF1 LEFTY1 PDPK1 ATM SHC3 ULK2 BMPR2 RPS6 DUSP8 CACNA1C NCK1 ID2 TFDP1 LAMTOR3 FOXG1 GDF6 BMP8A NRG1 CBL IGF1 ATG12 RPS6KA3 SMURF2 HOMER2 PMC6547588__F5 Involvement of LOAD risk factors at the BBB CD2AP APOE RAC1 ABCB1 PICALM PMC11583660__F1 Urinary estrogen metabolite before and after values CYP1B1 CYP1A1 CYP3A4 PMC4007997__F4 Molecular pathway analysis of regulated membrane protein changes in RLSCs as they undergo hepatocytic differentiation TES JUP LGALS2 EZR HEL113 CDH17 RPSA LGALS4 ENO1 FBLIM1 PMC7198750__F5 Cell interactions in TME engaging the cGAS-STING pathway HEL-S-92n FAS CGAS PMC3524689__F2 Proposed model of OGP(10-14) differentiation signalling MPL TGFB1 TPO ARHA PMC4007997__F5 Upstream regulator analysis of membrane protein changes in differently regulated proteins involved in cell-to-cell signaling and interaction JUP ACTN1 SNAI2 HEL113 H6PD ITGB4 PTGS1 HEL-S-108 HNRNPC CORO1C MAOA PMC5503689__F2 Inflammasome complexes: emerging mechanisms and effector functions CGAS TLR4 AIM2 IL1B PMC7198750__F3 Interaction of the cGAS-STING pathway with other DNA-sensing pathways and its role in cell survival SOCS1 TFAM TBK1 CGAS NLRP3 RELA AIM2 IRF3 TREX1 APAF1 MYD88 PMC5807683__F5 Pharmacological targeting of KLFs in vascular inflammation KLF4 TIEG2 KLF2 NR1C1 KLF5 MTOR SIRT1 PMC6177618__F1 Calcium‐sensing receptor signalling and trafficking FH PIR PTH PMC1236696__F1 IKK/NFKB signaling pathways LTBR RXRA RELB IRF3 VCAM1 IL1B PMC6814074__F2 Non-genomic mechanisms of thyroid hormones action in the brain MAPK1 TH STAT3 MTOR PMC2832144__F11 Proposed model for the signal transduction pathways involved in TGFB1-mediated fibroblast-myofibroblast differentiation CD44 EGF EGFR SMAD2 SMAD4 HAS2 PMC8080639__F1 General unfolded protein response pathway during ER stress ATF4 EIF2A XBP1 TRAF2 PMC4167033__F7 IGF but not the EGF signaling pathway is regulated by the NEDD4-PTEN circuitry EGF NEDD4 IGF1 EGFR PTEN IGF1R IRS1 PMC6028759__F1 Wnt antagonist and secreted frizzled-related protein 5: implications on lipid metabolism, inflammation, and type 2 diabetes mellitus SFRP5 APC CTNNB1 PMC7844295__F2 Biosynthetic pathways of glycerophospholipids in rat hippocampus ACSF2 ACSL6 LTA AGPAT3 LPCAT3 FLJ10842 HEL-S-25 GPX1 ACSS1 LTB LPA LPCAT4 LOX PLPP1 PC EPHX2 PMC7844295__F3 Glutathione metabolism HEL-S-22 MGST3 CNDP2 GPX4 GSTT2 LOC51064 GSTM5 GPX1 GSTA3 GSTM1 AGL HEL-S-26 HEL-S-64p NNT PMC9138696__F1 Stressing the Regulatory Role of Long Non-Coding RNA in the Cellular Stress Response during Cancer Progression and Therapy EGR1 ATM HNRNPK MYC RPA1 PMC7688371__F1 Oxidative Stress, Folate Receptor Autoimmunity, and CSF Findings in Severe Infantile Autism TH TPH2 PMC3816993__F2 Combined miRNAs and transcription factor regulation of inflammation in wound healing IL10 JUN FAS SP1 TLR9 IRAK1 IRF1 IL6 TNF TRAF6 CCL2 FOS TGFBR1 ALB NTF3 NFKB1 TLR4 DDIT3 SP3 CREBBP TLR7 REL CREB1 PMC7517787__F8 Mechanism model of exogenous MT in delaying the post-harvest decay of wax apples LOX STX2 PMC7738628__F5 Selected P5 and/or P10 enriched pathways CD40 DUSP10 CD79B SYK GRIN2B FAS PYCARD NFATC2 GABRB2 TNFRSF1A GSK3B PIK3R1 PLA2G5 GABRA4 MTOR MYD88 GABRG2 GABRB1 HMOX1 MAP3K8 PIK3C2B BTK PIG59 HSPB2-C11orf52 NTF3 MAP2K6 PRKCA CALB1 ATF4 GRIN1 ACVR2B JUN EGR1 INPP5D PTPN6 FOS CNTF GABRA2 HEL-S-102 DDIT3 CD200 BDNF HLA-A PMC4039984__F1 Chromatin Landscape and Transcription Factors in T-Cell Programming STAT3 BATF RUNX1 STAT4 IRF4 FOXP3 GATA3 RUNX3 PMC5220678__F2 Loss of Axin2 can cause MVD by shifting TGFB/SMAD3 pathway toward WNT/Beta-catenin and BMP signaling TGFBR2 BMPR2 SMAD1 TGFB1 DKFZp781O1323 BMP4 APC BMP2 SMAD6 TGFBR3 SMAD4 CTNNB1 PMC11889592__F3 miR-34 family has suppressor effects on cancer invasion, proliferation, and metastasis by regulating molecular pathway CDC2 BAX HMGB1 GDNF EGFR PTEN CCNE2 CDK6 PDGFRA BCL2 SIRT1 CCND1 NOTCH1 CDK4 PMC7738628__F6 “Synaptogenesis signaling” seIPA-path schematic representation in HI exposed P5 (upper panel) and P10 brains (lower panel) SYN2 CDH8 GRIN2B RASD1 GRIA3 GRIA2 EPHA2 EIF4EBP1 NTRK2 MTOR UNC13A NRXN3 CDH12 STXBP5 AP2M1 CAMK2A EPHB3 GRM8 CDH11 ATF4 GRIN1 SYT1 EFNB3 PMC3401681__F3 Mesenchymal stem cells (MSCs) may have both growth inhibitory and stimulatory effects on tumours STAT3 MSC IL6 PMC4614032__F1 mTORC1 signaling pathway RHEB TSC2 TSC1 PMC7401609__F3 Fat metabolism in the subcutaneous fat of yaks under long-term energy stress (ES) ACSL6 ACSL3 LEP ACOT8 PNPLA2 IL6 ELOVL5 FADS1 ACAD9 TG AQP7 LIPE ACOX3 PMC10869786__F7 The mechanism by which FXR promotes NSCLC metastasis STAT3 IL6ST PMC7401609__F4 Energy balance in yaks under ES by regulating fat metabolism ACAD9 PFKFB4 LEP SLC2A4 ACOX3 ACOT8 MTOR PMC8656796__F5 Therapeutic Efficacy of Variable Biological Effectiveness of Proton Therapy in U-CH2 and MUG-Chor1 Human Chordoma Cell Death JUN TNFRSF4 TRAF5 TRAF3 TRAF2 TNLG2B PMC8831562__F3 USPs and TGFB signalling USP15 USP4 SMAD2 GSK3B SMAD4 SMURF2 CYLD USP26 PMC10561274__F2 Inflammation associated signaling activated by fractalkine KEAP1 CX3CR1 CX3CL1 TNF PMC7719135__F2 Mechanism how MCPIP1 and cytokines mutually regulated in macrophages XPO5 TLR4 CCR2 TANK TRAF6 MYD88 PMC8831562__F2 USPs and NFKB signalling USP15 TRADD USP19 TAB3 TRAF6 TNF CYLD TRAF2 PMC3937154__F5 IPA graphic representation of the network “Cell death and survival, DNA replication, recombination, and repair, cellular response to therapeutics”. Nodes represent genes and lines show the relationship between genes TP73 FDXR TNFRSF10B PCNA BRCA2 NRAP NUPR1 PTEN BBC3 TYMS YY1 TNFRSF10A TRIM24 CCNE1 ISG15 SNAI2 DCAF6 PERP IRF3 IGF2 SPP1 NLRC4 PMS1 DDB2 LRRC17 RPS27L MOCOS BTG2 BRCA1 PRKDC RELA IKBKB CASP3 TNFSF10 GADD45A CASP10 PMC2770888__F2 Targeting EGFR resistance networks in Head and Neck Cancer STAT3 BAD PTEN GRB2 MTOR SRC CCND1 PMC7870996__F1 Dual regulatory effects of TRAP1 on the mitochondrial apoptotic pathway ATF4 EIF2A TNF CPD PMC7396304__F1 Quantitative Measurement of Redox State in Human Brain by 31P MRS at 7T with Spectral Simplification and Inclusion of Multiple Nucleotide Sugar Components in Data Analysis HEL-S-162eP MDH2 PMC7453310__F3 Alternative splicing regulation of the oncogenic MYC and RAS-MAPK pathways MAX EGFR SRPK1 MYC RAC1 EIF4E PMC11021402__F5 Fe and S binding by ISCU2 at consecutive stages of de novo [2Fe-2S] cluster biosynthesis FDX2 FXN PMC6918076__F6 Schematic illustration of AHR activation modulating HIV-1 transcription AHR CDK9 PMC7765317__F2 Nuclear factor-E2-related factor-2 (NRF2) pathway exerts antifibrotic effects NQO1 GCLC PMC7765317__F3 Reactive oxygen species (ROS) trigger fibrosis via several inflammatory pathways NLRP3 TXNIP TLR4 IL1B MYD88 PMC4710564__F7 Specialized pro-resolving mediators (SPMs) inhibit human B-cell IgE production JAK3 JAK1 PMC7340996__F2 Structure of the filaments containing Septins 7/9b/11 and Jun N-terminal kinase signaling pathway SEPT9 SEPTIN7 PMC12210160__F1 Anti-hepatitis B virus hepatic innate immunity in hepatocytes IL10 MAVS TLR3 MAL EZH2 TNF IL1B MYD88 PMC5514694__F9 Coordinating reactions in the intestine elicited by LGG in response to S LPL IFNG STAT3 CCR6 CCL20 PMC2820234__F3 Suggested signaling of the early stages of 1,25D-induced monocytic differentiation NR1i1 EGR1 CDK5 EBP CD14 PMC8314387__F2 Signaling Pathways Involved in Diabetic Renal Fibrosis SMAD2 SMAD4 PMC8314387__F3 Signaling Pathways Involved in Diabetic Renal Fibrosis SMAD2 CTNNB1 PMC11482726__F10 Working model for NONO positively regulating IRF3-mediated IFNB signaling pathway by detection of PRRSV N TBK1 MAVS NONO IRF3 PMC5628354__F5 Proposed deglycosylated metabolic pathway of Panax ginseng saponins by rat intestinal microflora ARAF RB1 F2 PMC7093422__F6 Detailed information of sub-pathway (AGE-RAGE signaling pathway in diabetic complications) in the KEGG PLCD3 STAT3 PIK3CA TGFB1 AKT3 SMAD4 TGFBR1 STAT1 COL1A1 F3 PRKCA MMP2 CCND1 BAX JUN PIM1 SELE VEGFD NFATC1 IL1A IL6 TNF RAC1 HRAS AGER FOXO1 NFKB1 CASP3 BCL2 VCAM1 CYBB PMC9143056__F2 Inflammation by Plant-Derived Nutraceuticals in Tendinitis STAT3 COX2 IL13 PMC5056326__F1 Epidermal growth factor receptor signaling along with co-activated other receptor tyrosine kinases PIK3CA EGFR BRAF PTEN MTOR KRAS PMC5056326__F2 Possible resistance pathways to epidermal growth factor receptor blockade; gain of mutations in KRAS, BRAF, and PIK3CA and upregulation of other receptor tyrosine kinases PI3 EGFR BRAF PTEN MTOR KRAS PMC3518557__F1 Targets and structure of compstatin HEL-S-62p C1S CP PMC8666287__F6 Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling NOTCH1 PMC3696549__F10 Reciprocal regulation by TLR4 and TGFB in tumor-initiating stem-like cells TGFBR2 IGF2BP3 TLR4 MTOR YAP1 TGFBR1 PMC3552454__F4 Advances in graft-versus-host disease biology and therapy HEL-S-92n STAT1 APC NOD2 TNF MYD88 PMC8460989__F8 Exosomes Transport Anti-Human Immunodeficiency Virus Factors from Human Cervical Epithelial Cells to Macrophages TLR3 MX2 ISG15 OAS1 PMC7313221__F4 Main mechanisms involved in the development of HCC CYP2E1 TLR4 MYD88 PMC4544723__F7 Proposed schematic showing targets of EBN action in the insulin signaling pathway MAPK1 PIK3CA INSR IKBKB GCK PMC8530523__F3 Epigenetic regulation of energy metabolism in obesity OGT SIRT1 SIRT6 PMC2631402__F4 The Legionella pneumophila replication vacuole: making a cozy niche inside host cells SDHA NOD2 BNIP3 NOD1 PMC4023801__F2 Proposed metabolic activation pathway of GS-6620 HINT1 CES2 CES1 PMC11613313__F2 Endometrial Receptivity Affected by Fibroids BMPR2 SMAD1 ADM HOXA10 BMP2 SMAD4 HOXA11 PMC6192166__F3 Proteomics and phosphoproteomics driven identification of the aberrant regulation of signalling pathways leading to poor patient survival MYLK2 STAT3 VASP RAF1 SHC1 SOS1 PXN VAV2 AKT3 ZYX RHO TNS1 RAC3 PRKCB STAT1 PLCG1 PRKCA TLN1 SRC SHC3 JUN HEL-S-28 FOS DOCK1 HEL114 HRAS GIT2 CRK CAPNS1 CSK ARHGEF7 MAPK10 JAK1 GRB2 PMC5836465__F3 Unfolded protein response BAX BCL2 ATF4 EIF2A TRAF2 PMC3528779__F6 Global Effect of Inauhzin on Human p53-Responsive Transcriptome RFWD2 TSC2 ATR PERP AMT CASP3 CDK2 ATM PTEN MYC PMC12131027__F5 Schematic model illustrating potential pathways after PRRSV infection in PAMs with identified DEPs based on our study SCARB2 TBK1 RFX5 IRF9 IFIT1 IRF3 B2M TRAF3 NFYB ISG20 STAT1 SLA2 RIGI CD74 MHC2TA TLR3 MX2 MX1 ISG15 JAK1 TYK2 CREB1 OAS2 PMC9654795__F1 Ferroptosis: A New Development Trend in Periodontitis SLC3A2 LOX GPX4 LPCAT3 FACL4 SLC7A11 NF2 PTGS2 GLS2 PMC10608450__F5 Protein–protein interactions between 341 members of antimicrobial peptides in Trachinotus ovatus NCAN ADK PLA2G1B APP CALCB CXCL14 PMC3925772__F7 Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module STAT3 RICTOR IL6 MTOR SRC PMC5275750__F1 Cancer Cell Metabolism and the Modulating Effects of Nitric Oxide PI3 MTOR VHL PMC6492140__F1 Global and specific regulation of translation initiation ELF2 EIF5 ELF5 EIF4E PMC5584588__F7 Stimulation of RNA Polymerase II ubiquitination and degradation by yeast mRNA 3’-end processing factors is a conserved DNA damage response in eukaryotes RBX1 PMC2071927__F2 TUNING IMMUNE TOLERANCE WITH VASOACTIVE INTESTINAL PEPTIDE: A NEW THERAPEUTIC APPROACH FOR IMMUNE DISORDERS VIP IFNG STAT1 TLR4 JUNB CD14 IRF1 JAK1 TBP PMC8740192__F1 Myostatin on the Growth and Development of Skeletal Muscle SMAD2 MYF5 SMAD4 MTOR PMC8339209__F2 Recent Progresses in the Treatment of Osteoporosis JUN SP1 APC ROR2 GSK3B LRP5 LRP6 RUNX2 CTNNB1 PMC8598918__F2 Receptor tyrosine kinases as druggable targets in glioblastoma: Do signaling pathways matter? SPRY2 EGFR CXCR4 PMC8598918__F1 Receptor tyrosine kinases as druggable targets in glioblastoma: Do signaling pathways matter? NF1 EGFR ERBB2 PTEN VILL PMC2360352__F1 Schematic depicting the central role of HER3 in mediating PI3K/Akt signalling downstream of the HER family BAD EGFR PTEN MTOR PMC4699279__F1 Gliadin peptides pass through the epithelial barrier paracellularly or transcellularly CXCR3 EGFR APC MYD88 PMC8203646__F8 Meta-analysis of gene signatures and key pathways indicates suppression of JNK pathway as a regulator of chemo-resistance in AML NLRP3 IL18 IL1B PMC7718059__F8 KEGG pathway enrichment of the S100 genes and their significantly related genes selected from the top 5 module analysis CRK BAD PMC11280316__F8 Suggested schematic illustration of the mechanism by which crocin could induce cell survival and exert anti-oxidative and anti-inflammatory effects in stressed cardiomyocytes BAX KEAP1 TLR4 NQO1 F3 PTEN MTOR MMD MYD88 PMC5581122__F7 Hypertriglyceridemia in female rats during pregnancy induces obesity in male offspring via altering hypothalamic leptin signaling NTS POMC MC4R ARC AgRP PMC8235527__F1 Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System RHEB TSC2 TSC1 PTEN PMC5796908__F1 Activated endothelial cells modulate allogenic T lymphocyte activity IFNG TH PMC6983837__F10 RIG-I activation in the context of influenza infection MAVS TRIM25 IRF3 PMC9220936__F2 MicroRNAs in the Regulation of Solute Carrier Proteins Behind Xenobiotic and Nutrient Transport in Cells SLC3A2 SLC7A11 MTOR PMC9300056__F3 Plant endoplasmic reticulum UPRome: A repository and pathway browser for genes involved in signaling networks linked to the endoplasmic reticulum BAGE MAX BAX SEC31A SEC23A SHD RET PMC4621122__F8 Hypothesized model for E4-ORF1-induced constitutive Myc protein expression mediated by EGFR, InsR/IGF1R, and PI3K INSR EGFR IGF1R MTOR MYC PMC9300056__F2 Plant endoplasmic reticulum UPRome: A repository and pathway browser for genes involved in signaling networks linked to the endoplasmic reticulum RPN2 AGO2 BAG6 PMC6421647__F6 hBM-MSCs-Ex treatment alleviates liver fibrosis in both HSCs and liver fibrosis tissues through inhibition of Wnt/Beta-catenin signaling (PPARG, Wnt3a, Wnt10b, Beta-catenin) and the downregulation of downstream gene expression (WISP1, Cyclin D1) WNT10B WNT3A CCND1 CTNNB1 PMC7461110__F1 Cellular Responses to Platinum-Based Anticancer Drugs and UVC: Role of p53 and Implications for Cancer Therapy BAX ATR ATM TIGAR MDM2 GLS2 PMC8859258__F2 Contribution of Epithelial and Gut Microbiome Inflammatory Biomarkers to the Improvement of Colorectal Cancer Patients’ Stratification COX1 COX2 APC MDM2 GRB2 PMC2971717__F1 Schema of the HER family signaling pathways EGFR HEL-S-11 GRB2 PMC3904369__F1A Charity begins at home: non-coding RNA contributes to DNA repair BRCA1 ATM DROSHA HDAC2 PMC3809843__F9 Gremlin regulation of LOXs in TM TGFBR2 BMPR2 LOXL2 LOX LOXL4 SMAD2 LOXL1 SMAD4 TGFBR1 PMC9367540__F2 Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders TFAM TREM2 TBK1 CGAS TLR4 TLR9 IRF3 PMC11955793__F6 hUCB-MNCs inhibit fibrosis process CDH2 BAD SMAD2 PMC12012570__F2 CIH modulates glial cells in the CNS through various mechanisms ROS1 NLRP3 SENP1 MYD88 PMC8743908__F2 Kynurenine Pathway in Acute Kidney Injury and Chronic Kidney Disease SIRT3 KMO SIRT1 PMC8859258__F4 Contribution of Epithelial and Gut Microbiome Inflammatory Biomarkers to the Improvement of Colorectal Cancer Patients’ Stratification PDF TRADD TNF TRAF2 PMC11955793__F5 Anti-inflammatory and antioxidant effects of hUCB-MNCs IL10 KEAP1 IL13 IL2 IL6 TNF PMC5973613__F7 Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms TXNIP IGF1R FFAR1 PMC2515131__F2 Signal transduction events initiated by Kit and FcERI leading to specific mast cell responses, and the integration of these pathways for the synergistic enhancement of mast cell mediator release LAT KIT GRB2 SHE PMC3908275__F5 Interaction of MSCs and HSCs CDH2 MSC SHH KIT SMO CXCR4 HES1 PMC4392459__F1 The CoA-dependent butanol pathways used for the production of propane in E HBD AHR PMC9032991__F8 Pharmacogenetics of Osteoporosis: A Pathway Analysis of the Genetic Influence on the Effects of Antiresorptive Drugs PDSS1 FDPS CYP1A1 PGGT1B FNTA PMC7492613__F3 JAK-STAT modulating genes in PMN-MDSCs in the circulation of CRC patients BCL2L1 GFAP LEP ADIPOR1 IRF9 APC STAT4 GH1 MTOR MYC PMC8698579__F1 YAP/Hippo Pathway and Cancer Immunity: It Takes Two to Tango TEAD2 CXCL5 CD19 PTEN CTLA4 IL8RB TEAD4 MYD88 PMC11414529__F2 Injury induced by histone methylation disorders in diabetic nephropathy affect the major effector cells of the kidney WDR82 EZH1 KLF2 NTRK3 EZH2 PAX6 CCL2 SFRP1 CTNNB1 WT1 SOX6 CTNNBIP1 HIPK2 ADAM17 DKK1 KLF10 DACH1 NOTCH1 PMC4389010__F1 The Th17 pathway and its involvement in psoriatic disease STAT3 IFNE IL10 CXCL5 CXCL1 IL6 CXCL6 CXCL8 CXCL3 IL-21 IF2D PDC MMP3 CCL20 PMC6478763__F1 Mechanisms supporting BRAF inhibitor resistance in melanoma STAT3 PIK3CA JUN AKT3 FZD7 BRAF PIK3R1 DUSP4 RYK SOX10 KRAS HRAS FOSL1 NRAS SRC CCND1 PMC8384742__F1 Gastrointestinal mucosal immunity and COVID-19 TMPRSS2 IFNG FOXP3 ACE2 PMC2268740__F1 Neuroarchitecture of Aminergic Systems in the Larval Ventral Ganglion of Drosophila melanogaster TH TRH DDC PMC3200079__F3 Homeostatic and leukemic expression of receptors, signaling proteins, and transcription factors along the B cell pathway PAX5 IL7R CD19 JAK1 PREB PMC6466196__F1 Schematic of IL-4 and IL-13 mediated signal transduction STAT3 STAT1 JAK3 JAK1 TYK2 PMC2890032__F2 Differential vulnerability of neurons in Huntington's disease: The role of cell type-specific features TH HEL70 BDNF PMC9316217__F9 Procyanidin B2 Alleviates Heat-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells TNF IL1B PMC11062289__F5 ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency NR1i1 FZD8 MYH10 ENPP1 SFRP1 WIF1 FGF23 PMC5360281__F2 Visualization of selected miRNA targeting events on the insulin signaling pathway (from WikiPathways) STXBP4 SNAP23 STXBP1 CSA2 RRAD SHC1 VAMP2 GYS2 PTEN FLOT2 SHC2 XBP1 INSR CBLC MYO1C PRKCA PFKM SHC3 JUN PTPN11 IRS4 FLOT1 FOS IRS1 RHEB CRK TSC2 CBL PRKCI TSC1 NPPA RAPGEF1 PTPRE SNAP25 PFKL TBC1D4 EHD1 PMC11868719__F4 Signaling pathway of LPS-induced apoptosis BAX TLR4 MYD88 PMC6456539__F2 Activation of autophagy process by extracellular vesicles STAT3 EGFR MTOR PMC11868719__F1 Using the String database to analyze protein interactions TCEAL1 TIRAP MCL1 TCF4 BBC3 PMAIP1 PLK1 BCR DUSP26 NPM1 RFWD3 SOX4 HTT HEL-S-44 NR1i1 MT1A SMYD2 SP1 USP11 SREBF2 SNCA DVL2 BCLAF1 RNF2 MAGEB18 TK1 MAGEA2B BCAP31 SPNS1 SCML2 KMT2E MAGEC2 TP63 ZNF35 AXIN1 SAFB PRKAB2 BCL2 HINFP BAK1 NCL SPOPL VRK1 PPIF PPP3R1 PCGF2 NUMB PPP2CA MDM4 SUMO1 SPOP TLR4 AIMP2 CHEK2 CEBPZ APP HEL-S-283 CEBPB ETS2 CUL9 NFYB HDAC1 MBL2 ZNF420 CREBBP RYBP EP300 RCHY1 ZNF76 HEL164 RFWD2 CXXC1 RNF4 ACD NR0B2 PIN1 IRAK4 PEX26 HUWE1 TXN BCL2L2 TRIM24 MDM2 TBCB TPT1 SIAH1 UVRAG PIAS2 TP53BP1 HEL-117 UHRF2 PLEKHO1 NOC2L RUVBL1 SIRT1 CISD2 BAD PYCARD BRD7 PIK3R3 PML PHLDB2 SFN NOX4 STAP2 LY96 RPS3 BAX HMGB1 UBC WRN TICAM2 MAL MED1 PARP1 NCOR2 NUAK1 FOXO3A HEL-S-102 FADD YWHAZ PMC11868719__F2 Using the String database to analyze protein interactions SMAD1 APPL1 KEAP1 RNF7 S100A8 AK3 CCNA2 MYC CAMK2A FYN BCL10 SNAI1 TTC3 HTT HEL-S-44 NOS2 TINF2 GSKIP APC LRP6 SNCA TNF TSC1 TK1 HEL-S-68p AXIN1 PEBP4 CARD19 ZNF835 SLC41A3 GMCL2 BTBD1 CEP76 ENKD1 TBK1 BICD1 PRPF18 ZNF587 GPKOW DEAF1 NCAPD3 STK4 PPP2CA PRKCB SHARPIN SUMO1 PLCG1 AMOT CEBPZ APP CLTC NBR1 LRRK2 OSGIN1 FASN RNF31 ANXA1 PPP2R1A NR3C1 GIT2 NFKBIA CREBBP ERBB2 CDC37 SYT1 PRUNE2 AURKA CARD11 PRKCZ TXN ZFPM1 SRC CYLD GNB2 ASXL1 MCM7 ZC3H12A FOXO1 CDK2 SNW1 SLU7 TNIK PPL SIRT1 KRT18 ATR HEL113 MAVS TNFAIP3 RBCK1 EGFR RELB TANK SQSTM1 SETDB1 MTOR IKBKG CTNNB1 STAP2 RARA RPS3 RIPK1 ATM CALB1 CHUK FKBP6 DACT1 UBC GAL MESD SP7 FOXO3A NFKB1 GYS1 RELA TRAF2 CARD9 PMC7877795__F4 Origin of tumor- and metastasis-associated macrophages in mouse models of breast cancer CXCL12 EGF CSF1 HGF CCL3 IL4 CTLA4 CCL2 PMC7855621__F2 Centriole and cilium biogenesis CEP164 C2CD3 FBF1 CCDC41 SCLT1 CEP89 PMC8946735__F3 Key Genes and Biochemical Networks in Various Brain Regions Affected in Alzheimer’s Disease GNG2 GNAS SLC17A6 GRIA2 SLC12A5 GABRE KCNJ3 GNG4 GLS GABRB3 GABBR2 GNG3 PMC8905719__F2 RAS pathway regulation in melanoma SOS1 NF1 SOS2 PTPN11 MDM2 GRB2 MTOR MYC FOS PMC7438927__F6 Canonical Pathway of ‘Actin Cytoskeleton Signaling’ in IPA with AA-specific/enhanced genes in ABI2 EGF TRIO PXN APC GNG12 ARHA FLNA DOCK1 HEL114 CRK F2 GRB2 SRC BAIAP2 PMC7438927__F7 Relationship between a network of DEGs and the canonical calcium signaling pathway BMP10 CPA4 PCDH10 REN SOSTDC1 HAND1 HP ITLN2 XIRP2 ANKRD2 CP PMC7438927__F8 Networks of an unreported AA-specific/enhanced DEG (CHRNE) PRG4 NTS COMP ASIP CACNA2D2 CFH HAMP FYB2 OPN5 RAPSN CNTFR CHRNE THBS4 TIMD4 CALB2 CP PMC3590362__F1 AGE/RAGE signaling pathway in NetSlim- This map represents the NetSlim reactions of AGE/RAGE signaling pathway in different cell types CDC42 STAT3 MMP14 ALPL TIRAP DDOST EGFR SMAD2 CYCS PRKCZ ATF2 INS IRAK4 PRKCB MYD88 MAPK14 EZR REN FOXO4 INSR MSR1 PRKCA CHUK MMP2 SRC HEL-S-44 MMP7 CASP9 NOS2 JUN SP1 HEL70 MMP9 ARHA HRAS FOXO1 NFKB1 RELA IKBKB CASP3 NFKBIA PMC4972490__F1 BRCA1 and BRCA2: different roles in a common pathway of genome protection BRIP1 RAD52 TOPBP1 ATR RAD51 BRCA1 H2AX BRCA2 RNF8 ATM PALB2 MDC1 PMC6335777__F2 Ketamine on the glutamatergic synapse RHEB EEF2K HEL-S-162eP MTOR BDNF PMC2675030__F3 Steps in the generation of Th17 cells STAT3 IL21R IL23R RORA PMC9218220__F3 Reactive Oxygen Species and Metabolism in Leukemia: A Dangerous Liaison NOX5 NOX3 HEL-S-162eP DUOX1 PDK2 DUOX2 NOX4 CIT PMC3023199__F3 PPARG ligand treatments increase expression of mitochondria-associated metabolic pathways in adipose tissue TRO ALDH2 EHHADH PCCA BCAT2 PMC4862319__F1 Simplified schematic of signaling junctions that integrate the recognition of pathogen, host or environmentally derived DAMPs and dAMPs by their cognate receptors HMGB1 TBK1 CGAS MAVS TLR9 AIM2 IRF3 IFI16 IRF7 MYD88 NLRP1 NLRP3 TLR3 IL16 TLR4 TLR7 IL1B PMC3023199__F4 Dysregulated expression of fatty acid and cholesterol synthesis genes in liver is reversed by PPARG ligand treatments POR GPAM FAS SQLE HEL-S-5 PMVK ACACA MVK PMC5727914__F5 Interferon signaling in HPV-containing keratinocytes TBK1 IFNGR1 CGAS EGFR IRF9 IRF1 IRF3 IRF7 IFNG IFNK STAT1 IFNGR2 IFNAR2 IFNAR1 JAK1 TYK2 PMC3142627__F1 Procession to Pediatric Bacteremia and Sepsis: A Series of Covert Operations and Failures in Diplomacy LTA APC NOD2 NOD1 CR1 PMC4394435__F1 The ubiquitination pathway NEDD4 UBE2B UBE2D2 UBA6 RNF6 TRAF6 SKP2 PMC4394435__F2 The SUMOylation pathway RANBP2 CS SAE1 PMC8894020__F5 Quantitative Proteomics Analysis Expands the Roles of Lysine Beta-Hydroxybutyrylation Pathway in Response to Environmental Beta-Hydroxybutyrate MTCH2 HSPG2 GEMIN5 YY1 ATOX1 HEL-S-69 TFRC KLHL42 LOX HCFC1 HEL-S-2a RPL29 THOC1 ZC3H11A SPCS2 EIF4B MSH2 FLNB LARP1 FASN PNPT1 PTPN11 HEL-S-94n RBPJ EEA1 MAGOH HEL114 RANBP2 SPC25 ARIH1 NONO PALLD ESD RPS25 PMC4424773__F2 Proposed signaling pathway for fat taste CD36 STIM1 TRPM5 PMC7367654__F7 Triptolide-induced apoptosis in non-small cell lung cancer via a novel miR204-5p/Caveolin-1/Akt-mediated pathway SIRT3 SIRT1 PMC8879981__F1 Unravelling Formaldehyde Metabolism in Bacteria: Road towards Synthetic Methylotrophy GAA MCC MSC PMC5757547__F2 Glucose-lipid crosstalk in diabetic kidney disease TG FAS NR1C1 MTOR SIRT1 PMC3321211__F4 Apoptotic cascade BAX CASP9 PAF1 CASP3 PMC8033373__F4 Biomarkers and key pathways in atrial fibrillation associated with mitral valve disease identified by multi-omics study TH PLTP PMC9689226__F8 Overcoming Anxiety Disorder by Probiotic Lactiplantibacillus plantarum LZU-J-TSL6 through Regulating Intestinal Homeostasis PMCH NTS TRH LEP OXTR LHB SCTR TSHR HEL-S-62p TACR2 CRH GHRH GIP NMU PRLHR FSHR LPA NPFF UTS2 APLN NPY HCRT OXT GRPR VIP MLN TAC3 GAL LEPR TRPV1 TACR3 TRHR NR3C1 CALCR SST MLNR GCG APELA UTS2R PRL PTH SCT AVP PMC4427070__F12 Summary of the three-way interaction among AMPK, SIRT1, and eNOS.Notes: AMPK and SIRT1 exhibit a bidirectional interaction in response to cellular energy status and regulate lipid metabolism and inflammatory status FAS NR1C1 IL6 SIRT1 PMC6767293__F4 Effect of corilagin on the TGFB signaling pathway in ovarian cancer PCNA SMAD2 MDM2 PMC6071523__F8 Schematic illustration of the crosstalk between CAFs and cancer cells in the tumor microenvironment CTNNB1 PMC4118286__F1 Major physiological functions of the endoplasmic reticulum and their perturbations cause ER stress and activate the unfolded protein response ATF4 EIF2A PMC12127259__F2 Photo shows the signaling pathways in which each long non-coding factor interacts through different MIR signaling pathways (By Figdraw PCDH10 SHOX SHOX2 SOCS3 PMC6767293__F3 The effect of corilagin on the Notch-mTOR signaling pathway in cholangiocarcinoma MAML1 MTOR HES1 NOTCH1 PMC4061161__F1 The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment STAT3 CRK HGF CRKL RHO GRB2 MTOR SRC PMC12127259__F3 Photo shows the signaling pathways in which each long non-coding factor interacts through different MIR signaling pathways (By Figdraw HEL113 VEGFA PMC12127259__F4 Photo shows the signaling pathways in which each long non-coding factor interacts through the Hedgehog signaling pathway (By Figdraw PTCH1 SMO PMC3035824__F5 Mapk signaling pathway from KEGG MAX MAFK EGFR HEL-S-11 PMC4287242__F5 Signaling pathways associated with capacitation-related proteins NOS2 PRKCI RHPN1 SUCLA2 SP1 BLZF1 GPX4 HEL-S-162eP ACRBP RAB2A ACR PMC3955735__F5 Glucose and glutamine metabolism is altered by oncogenic K-Ras GLUD1 RPE GOT2 RPIA GLS HEL-S-133P HK2 GFPT1 ENO1 ME1 HEL-S-30 PMC6202151__F7 Schematic depiction of proposal mechanism by which AF confers anticancer actions in TamR breast cancer cells BAX ITGB4 ITGA6 SRC PMC5828949__F2 The role of renal dipeptidyl peptidase-4 in kidney disease: renal effects of dipeptidyl peptidase-4 inhibitors with a focus on linagliptin FGFR1 DPP4 TGFBR1 PMC8507250__F8 Nanoselenium transformation and inhibition of cadmium accumulation by regulating the lignin biosynthetic pathway and plant hormone signal transduction in pepper plants CD2 CAD PMC9267745__F6 VEGFA, KRAS, and NFE2L2 Oncogenes by MicroRNAs in Head and Neck Cancer NFE2L2 MTOR VEGFA PMC9414852__F8 MOBT Alleviates Pulmonary Fibrosis through an lncITPF–hnRNP-l-Complex-Mediated Signaling Pathway HNRNPL FMN1 SMAD2 SMAD4 MEF2C PMC3365812__F3 Hh signaling pathway and their inhibitors SUFU SMO MYC PMC11502918__F5 An intricate relationship between ER stress and lncRNAs: bidirectional relationship between ER stress and lncRNAs in the context of the UPR pathway ATF4 XBP1 PMC6052836__F1 The regulation of the anti-viral signaling pathway CGAS TLR9 AIM2 PTEN IRF3 IFI16 IRF7 TRAF3 TRAF6 PIN1 MYD88 TLR3 TLR7 PMC11502918__F6 LncRNAs in ER stress-driven HCC progression BAD ATF4 PMC7830727__F1 Ferroptotic cell death pathway FTH1 FTL GPX4 PMC11502918__F4 Diverse lncRNA-medicated signaling pathways targeting different hallmarks of cancer (lncRNAs written in black and red color represent oncogenes and tumor suppressors, respectively) MTOR TUG1 MCM3AP SOX4 PMC7830727__F2 Necroptotic cell death pathway TRADD MLKL TRAF1 TRAF2 FADD PMC11502918__F1 Various stress at ER levels causes the induction of UPR pathway ELF2 ATF4 XBP1 PMC7830727__F3 Canonical, non-canonical, and caspase-3-dependent pyroptotic cell death pathway NLRC4 NLRP1 GSDMD NLRP3 AIM2 DFNA5 IL1B PMC8771506__F6 POU4F3 Acts as a Tumor Suppressor in Lung Adenocarcinoma via the Endoplasmic Reticulum Stress Signaling Pathway POU4F3 ATF4 EIF2A PMC3936289__F4 Major crosstalks between the PI3K and the MAPK cascades TSC2 RICTOR GRB2 MTOR MYC IRS1 EIF4E PMC11205484__F2 Biosynthetic Pathways of Protectins and Maresins in Macrophages and MaR-2 in Brown Adipose Tissue Activation TREM2 COCH CCR2 HP LGR6 PMC8584803__F1 Biochemical Markers for the Diagnosis of Mitochondrial Fatty Acid Oxidation Diseases HEL-S-62p C2 CPT2 PMC6189190__F5 The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition MAX ECSIT JUN FAS TRADD CD14 TNF TRAF6 FLNA STS NF1 GRB2 TRAF2 PMC7887571__F1 a) Schematic illustration of the HCJSP prodrug nanoparticle prepared via the host–guest interaction between HA‐CD and AD‐SS‐JQ1 and AD‐SS‐PPa BRD4 HEL-S-133P HK2 PMC5804041__F2 PPARA-RXR signaling pathway PPARG JUN FASN NR1C2 NR0B2 RXRG SHE IRS1 NR2F1 NR1C1 CHD5 RXRA GRB2 PMC7399876__F1 Tax activation of canonical and noncanonical NFKB signaling MAP3K7IP1 CADM1 PDLIM2 RNF8 TRAF6 CYLD PMC6130939__F11 GRK2 mediates TCR-induced transactivation of CXCR4 and TCR–CXCR4 complex formation required for PI3KG/PREX1 signaling and robust T cell cytokine secretion ADRBK1 PREX1 SRC CXCR4 PMC4669719__F8 Schematic diagram of the NRG1-ERBB4-NRG1 autocrine pathway NRG1 ERBB4 ERBB2 PMC5509685__F1 Simplified sphingolipid metabolic pathway GLS SGPL1 SPHK2 SPHK1 PMC5400657__F1 Long non-coding RNAs: a rising biotarget in colorectal cancer CD44 TCF7L2 ERBB4 BCL2 ZEB2 MYC CTNNA1 CREB1 PMC8488354__F4 Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson’s Disease GAA STAT3 ChAT PMC8040296__F7 PI3K-AKT Signaling Pathway TH TNC OSM MYC IRS1 PMC8040296__F8 Protein-protein interaction in the PI3K-AKT signalling pathway and ECM-receptor interactions TNC THBS2 AKT3 THBS3 IL2RA LAMC1 COL1A1 F2R OSMR PDGFC COL4A2 FLT1 FGF23 VWF THBS1 COL1A2 SGK1 LPAR1 VEGFA IL6 ITGA2B PDGFRA GNB4 EN1 THBS4 PMC8488354__F3 Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson’s Disease GSK3B APP CTNNB1 PMC4961262__F1 The SDF1/CXCR4 signaling pathway TH TBX1 FGFR1 SHH TBXT ROBO1 FGF8 PMC3694992__F1 Neuroimmune Signaling: A Key Component of Alcohol Abuse HMGB1 TIRAP TLR4 CD14 PMC3798191__F5 The relationships between the RA, FGF and Notch pathway in Xenopus PSM CELF1 RBPJ FGF8 PMC5278230__F7 Proposed mechanism underlying HSYA-SDT-induced autophagy and inflammation inhibition in THP-1 macrophages SI MTOR ATG5 PMC8449655__F1 De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3‐hydroxylase with 2‐hydroxylase side activity FH F3 ENO1 PMC10486718__F1 Schematically representing the signal transduction and biological activities induced by androgen in ER-positive breast cancer cells EGF SGK1 SRC RAC1 PMC4461014__F5 Dual function of genes THBS1 TIMP3 APC MMP9 VEGFA ARHA TNF MYC CTNNB1 BAMBI SOST TLR4 CER1 MMP2 DAAM1 PMC10486718__F2 Schematically representing the signal transduction and biological activities induced by androgen in ER-negative breast cancer cells EGF SGK1 PAK1 SMAD2 TLN1 SRC RAC1 PMC10486718__F3 Diagram illustrating the androgen-mediated signal transduction via integrins and the resulting biological activities TF MUC1 MTOR PMC9354823__F1 Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy ACLY OGA ACSS2 OGT FH GLS HEL-S-162eP PDC ACSS1 PMC6603400__F1 Diagram of ellagic acid target proteins from the DrugBank database CA4 RPTOR PLN CA7 SYK TRIO SQLE BLNK PRKCB CA3 CA12 RICTOR PRKCA CSNK2A1 HEL-S-11 CA9 CA14 PMC10874560__F3 Representative bacterial-origin immunostimulants signaling pathway NLRC4 MPL TIRAP TLR4 TLR9 IRAK1 TLR5 IRF3 IRF7 HP TRAF6 MYD88 PMC8291481__F4 Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain ACHE TH PC CHDH ChAT PMC6878604__F1 FGFR pathway.FGFRs dimerize upon ligand building and trigger a downstream cascade of signaling pathways FRS2 FGFRL1 GRB2 PMC3365812__F1 Wnt/Beta-Catenin signaling pathway and their inhibitors BCL9 APC GSK3B LRP5 LRP6 MYC PMC2270852__F5 Schematic of signaling pathways in PDAC STAT3 EGFR SMAD4 PTEN MTOR PMC5819921__F4 Bioinformatics prediction of genes interacting with RAC1 using Ingenuity Pathway Analysis CTNNA2 BIRC5 BAD CASP8 HEL-S-125m MAK PAX8 LAMB3 LAMB4 WNT4 LAMA3 RAC1 PMC9437975__F7 Integrative analyses of mRNA and microRNA expression profiles reveal the innate immune mechanism for the resistance to Vibrio parahaemolyticus infection in Epinephelus coioides CD40 IL19 PERP CFH BCL2 HEL-S-11 CS CCL2 PMC6250852__F1 Oxidative stress and activation of Cerebrovascular Endothelial Cells TLR4 VCAM1 ARHA IL1B MYD88 PMC3865646__F2 Apoptosis by hypothermia CASP9 CASP8 CASP3 PMC8905719__F5 RAS pathway regulation in melanoma SOS1 PTPN11 GRB2 PMC4461014__F1 Dual function of TAK1 MAP3K7IP1 TAB3 TRAF6 PMC3132106__F1 Summary of the extracellular interactions between Wnts, Wnt receptors and Wnt regulatory proteins MUSK RYK CTNNB1 PMC3176435__F2 Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants AGO4 PMC10742473__F4 Canonical and alternative signaling pathways in B-cells SYK BTK BCR PLCG2 BLNK CD19 LYN MTOR PMC7494657__F4 Networks under “Pathways in Cancer” that were enriched in Masquelet bone WNT16 GNB3 GNG13 FZD2 GNB5 PRKCZ WNT9B WNT7B WNT5B TGFBR2 ADCY3 EDN1 EDNRA EDNRB SMO NOTCH3 CCND1 BDKRB2 PMC10150004__F1 Infection routes, invasion mechanisms, and drug inhibition pathways of human coronaviruses on the nervous system TMPRSS2 CXCL9 TH DPP4 CCL4 CXCL10 CCL2 ACE2 PMC2769198__F2 Smad4: gatekeeper gene in head and neck squamous cell carcinoma EGF HGF SMAD4 PMC7658242__F8 IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling ATF4 PMC3201689__F1 Diagram illustrating the DNA base excision repair (BER) pathway LIG1 FEN1 APEX1 PMC6058973__F2 Regulation of GPCR signaling IFNG STAT1 XBP1 PMC5655209__F8 Glypican-3 induces oncogenicity by preventing IGF-1R degradation, a process that can be blocked by Grb10 GRB10 IGF1 GPC3 PMC2427358__F8 Summary of GRTH impact in apoptotic pathways in germ cells BAD TRADD TRAF2 FADD PMC6314240__F2 TGFB signaling as well as the role of TGFB signaling pathway in cancer onset and progression SMAD2 SMAD4 RHO MTOR PMC6617169__F2 Signaling pathways involved in the protective effects of tea bioactive compounds against cardiovascular diseases BAX TRPV1 PTEN EP300 NCOA6 PMC2424295__F2 Feedback loops in NFKB signaling TLR4 IRF3 MYD88 PMC3775269__F6 CTLA4Ig inhibits effector T cells through regulatory T cells and TGFB IFNG CD80 APC PMC4373383__F1 Network of HMGA regulatory mechanisms in human carcinomas HMGA2 HMGA1 PPP2R2A TGFBR3 PMC5310720__F1 PD genes and autophagy-endolysosomal pathway(s) WDR45 VPS35 PINK1 SYT11 SYNJ1 FBXO7 SMPD1 PMC6854084__F6 Proposed model for apoptosis suppression via R-Ras pathway by RasGRP2 BAX HK2 PMC8966724__F2 Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury BAX TBK1 CGAS NLRP3 TLR9 IRF3 PMC8196476__F3 Innate immunity, inflammation activation and heat-shock protein in COVID-19 pathogenesis NLRP3 TLR3 IL18 IRF3 IRF7 TLR7 ACE2 MYD88 PMC11050413__F10 Mechanistic map illustrates the role of NDUFA6-DT as a sponge for miR-455-3p in gliomas, disrupting its ability to suppress YWHAH/YWHAG expression BAD CDC25B YWHAG PMC9605422__F9 Research Progress on Fungal Sesterterpenoids Biosynthesis IPP BTC PMC3196210__F2 Relationships of different neurons in the striatum and neurotransmitter signaling involved in interval timing GC BDNF NACA PMC2647704__F5 Schematic of selenoprotein synthesis SLA PSTK PMC9688625__F7 Targeting Wnt/Beta-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF IFNG GPX4 CTNNB1 PMC8233150__F8 A20/Nrdp1 interaction alters the inflammatory signaling profile by mediating K48- and K63-linked polyubiquitination of effectors MyD88 and TBK1 TBK1 IRF3 TRAF6 MYD88 PMC3180925__F1 Wnts signal through a “canonical” pathway involving Beta-catenin mediated transcriptional regulation (at left) and through “non-canonical” pathways involving calcium and Rac/JNK-mediated signaling (at right) FAS APC CTNNB1 PMC11668870__F2 TRIM14 plays a double-edged role in cancer FUS STAT3 TRIM14 BAX TBK1 CGAS IRF3 DVL2 MTOR TCF19 MGMT PMC11668870__F3 Emerging discoveries on the role of TRIM14: from diseases to immune regulation TRIM14 NLRP3 TNF PMC11724432__F4 Mitochondrial Apoptosis and Inflammation CGAS NLRP3 IRF3 APAF1 PMC7407293__F1 Nuclear factor-kappaB (NF-kappaB) signaling pathway CD40 BCR RELB PMC11668870__F4 Expression of TRIM14 is upregulated in response to inflammatory stimuli, subsequently enhancing the expression of pro-inflammatory factors USP14 TRIM14 RNF125 TLR4 RELB TNF OPTN KDM4D CTNNB1 BRCC3 PMC11668870__F5 Emerging discoveries on the role of TRIM14: from diseases to immune regulation PPP6C USP14 TRIM14 STAT1 CGAS MAVS IRF3 IRF7 PMC7481463__F6 Biomarker metabolites network based on intelligent pathway analysis use IPA analysis P2RX7 IL6 UNK PMC9273868__F5 Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform P2RY14 ADRA2B KCNB2 KCNS3 PTPRC VCP TRAF2 STUB1 HEL-S-44 NR3C1 PMC7046484__F8 Schematic illustration summarizes the epiregulin promoted trophoblast cells invasion by targeting poFUT1 and O‐fucosylation on uPA, which stimulated PI3K/Akt signalling pathway and MMP 9 activity CDH2 EGFR PLG POFUT1 MMP9 PMC8674574__F2 Programmed Cell Death of Macrophages, Endothelial Cells, and Tubular Epithelial Cells in Sepsis-AKI RIPK3 BAX GSDMD SH3YL1 NLRP3 MLKL TLR4 NOX4 IL1B PMC8557391__F2 Nrf2/Keap1/ARE signaling: Towards specific regulation KEAP1 MAF PMC7961726__F2 Representation molecular mechanisms underlying the tumoral properties of glioma cells DGCR8 EGFR TNFSF6 PTEN FOS MGMT PMC11594620__F1 Metabolic pathway of complex sphingolipids in budding yeast Saccharomyces cerevisiae ORM1 GHB3 ORM2 PMC3784667__F2 Intracellular cycling of MUC1MUC1 is phosphorylated by EGFR and other receptor tyrosine kinases EGFR MUC1 SRC PMC3912412__F6 Interaction of CLL cells and the lymph node microenvironment JUND FCGR2B FOSB TNFAIP3 CD72 JUNB CD22 DUSP4 TNF DUSP2 FOS CD83 C2 CXCR5 IL1B PMC12015243__F6 EPHA5 promotes cell proliferation and inhibits apoptosis in Follicular Thyroid Cancer via the STAT3 signaling pathway STAT3 TIMP1 MYC CCND1 PMC6315659__F2 Regulation of the Hippo/YAP signaling pathway in malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) LATS1 EGF LATS2 EGFR NF2 PMC8396181__F2 Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects HECTD1 MYH10 FUZ PMC6160868__F1 Wnt/Beta-catenin driven mevalonate metabolism promotes EMT ACLY HMGCS1 IPP HMGCR PMVK MVD FDPS MVK CTNNB1 PMC7695367__F7 The proposed mechanism of radiation-induced tumor repopulation in NSCLC H2AX CASP3 ATM PMC7014214__F2 Anticancer mechanisms of phytochemicals on gastric cancer ATR ATG12 MMP2 ATF4 NOTCH1 PMC2597223__F1 Pathways of apoptosis BAX ARC FADD PMC11717529__F7 Mechanism of action of hsa_circ_0109623 and hsa-miR-146b-3p and their downstream target gene SORT1 in the pathogenesis of AIH STAT1 SORT1 STAT4 PMC7977493__F8 Stiffness of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis via Mechanotransduction and Canonical Wnt Signaling SMAD1 DKFZp781O1323 APC RHO RUNX2 PMC3765909__F2 Mechanism of blockade of the Wnt signalling pathway by osteocytes LRP5 LRP6 PMC2974212__F3 Critical growth factors and signalling pathways controlling human trophoblast invasion EGF HGF RHO MTOR PMC7294938__F3 Mechanotransduction and pathways regulating cytoskeleton during metastasis PIEZO1 PIEZO2 ARHA MTOR PMC7083089__F4 Secondary structures at CFSs can impede replication, resulting in fork stalling and cleavage to cause fragility ATR SLX4 PMC6711159__F1 Closer Look at Pyroptosis NLRP3 TLR4 S100A8 IL18 TRAF6 IL1B CTNNB1 MYD88 PMC6020732__F2 AhR in breast cancer and the role of dietary compounds TDO2 COX2 BRCA1 AHR PAH CYP1B1 PMC4486131__F5 OFE treatment counteracted TGFB1-activated SMAD pathways CDH2 CDH11 SMAD2 PMC8345973__F1 Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease DAO PMC7412635__F7 The dichotomous effects of VCD on follicular development RPS6 PTEN GDF9 NOBOX PMC8942302__F3 STAT3 pathway in cancers: Past, present, and future SOCS1 STAT3 EGF OSM COX2 TLR4 EGFR TLR9 SOCS2 SOCS3 SRC PMC4022607__F1 Angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development LATS1 LATS2 TEAD2 TEAD3 COIL AMOTL2 AMOTL1 TEAD4 PMC4453519__F3 Activation of the cytokine-cytokine receptor interaction pathway in incubations with BL21 or W3110 TNLG5A FLT3 IL10 CSF2 TNFAIP3 ACVR1B BMP4 CCR6 VCAM1 IL8RB TNFSF10 TNF PMC4987729__F2 Processing of engulfed dying cells requires LC3-associated phagocytosis (LAP) and promotes an anti-inflammatory response GABARAP ATG3 ATG12 UVRAG ATG5 ABCA1 RAC1 PMC11704872__F4 The IGF-1 Signaling Pathway in Mitophagy IGF1 BNIP3 NRF1 PMC11279976__F2 Common metabolic pathways of NAD+ and NMN NNMT NRK NAPRT HEL-S-90n NMNAT1 NAMPT NMNAT2 NMNAT3 PMC11704872__F3 Inhibition of autophagy by the IGF-1 signaling pathway RHEB TSC2 BAD TSC1 IGF1 ULK1 IGF1R DEPTOR IGF2 ULK2 IRS1 PMC2754696__F1 CIE and CDE pathways showing lipid content and regulatory molecules CDC42 EHD3 ARF6 SRC PMC8393605__F2 Exploring the Interplay of Telomerase Reverse Transcriptase and Beta-Catenin in Hepatocellular Carcinoma KLF4 APC GSK3B TERT TCF4 CTNNB1 PMC10218028__F2 SNPs affecting NET formation KIF26B SYK TNFAIP3 TMPRSS13 MPO PMC9151343__F1 Metabolic engineering of Vibrio natriegens for anaerobic succinate production FH MAL PTS CS CIT PMC12080488__F4 Figure illustrates the JAK/STAT signaling pathway and its role in cancer progression, highlighting its influence on tumor invasion, progression, autophagy, and apoptosis STAT3 JUNB GSK3B IL6 TWIST1 PMC6529540__F3 Omics analysis discovered high-confidence networks involved in AD HSP90AB1 UBC PIK3R1 APP CTNNB1 PMC10962118__F9 Mechanistic map of PELI1 ubiquitination of RPS3 activating the PI3K/AKT/GSK3B signaling pathway, promoting p53 degradation, and thus facilitating progression in PC RPS3 MDM2 PELI1 PMC6359191__F1 Cartoon representing the osteolytic and osteosclerotic vicious cycles EGF SOST IGF1 WNT3A WNT1 IL11 IL6 PMC10851593__F4 Lignin synthesis pathway map CAD INS PMC6348604__F1 Apoptotic signaling pathway BAX BAD BCL2 PMC5542661__F1 Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge RGS12 DYRK2 ANXA3 SIAH1 C1orf21 EBNA1BP2 HRAS DUSP19 ATP6V0A2 RAP1A TMEM185B RB1CC1 TMEM185A ADARB1 JSRP1 CISH QRICH1 PFKM UNK PMC5041942__F2 Dissecting dysfunctional crosstalk pathways regulated by miRNAs during glioma progression VEGFA LSM2 PMC7505161__F3 Toll-like receptor 4 (TLR4) activation in the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection TLR4 IL6 ACE2 PMC3328281__F1 Molecular changes of serous carcinogenesis RB1 PIK3CA CDKN2A CCNE1 BRCA1 BRAF ERBB2 DOCK4 KRAS PMC9501394__F2 Pharmacological Effects of Houttuynia cordata Thunb (H. cordata): A Comprehensive Review BAX KEAP1 BCL2 PMC11727388__F4 Aberrant tumorigenic ECM modulates several intracellular signaling pathways involved in tumor development and progression CD44 PIEZO1 AMOT SMAD2 APC GSK3B SMAD4 RHO NF2 MTOR SRC HEL-S-15 PMC2224766__F3 Proposed metabolic pathway for PSI-6130 CDA DCTD PMC2825553__F1 Interplay of cellular stress signals with apoptosis pathways BAX FADD PMC8253836__F1 Consolidated bioprocessing for bioethanol production by metabolically engineered Bacillus subtilis strains MALL PTS PDC PMC9584705__F8 Methylation-Mediated Silencing of RBP7 Promotes Breast Cancer Progression through PPAR and PI3K/AKT Pathway TF PTEN RBP7 PMC2739091__F8 Schematics of the effect IL-1B on the alveolar capillary barrier ARHA IL1B CTNNB1 PMC7016983__F2 Metformin (MET) AMPK dependent signaling RHEB TSC2 EIF4B CAD ULK1 TFEB PML MTOR EIF4E PMC7216182__F6A BST Stimulation Induces Atrophy and Changes in Aerobic Energy Metabolism in Rat Skeletal Muscles—The Biphasic Action of Endogenous Glucocorticoids CORT HSD11B2 HSD11B1 PMC9457820__F6 Small Molecule Inhibitors for Hepatocellular Carcinoma: Advances and Challenges APC GSK3B IL6 CTNNB1 PMC2631033__F1 Tumor necrosis factor and cancer, buddies or foes? CASP9 TRADD CASP3 TNF TRAF2 FADD PMC9657218__F4 Contribution of Microhomology to Genome Instability: Connection between DNA Repair and Replication Stress RAD52 RAD51 DNA2 ATM PARP1 PMC6498051__F7 IFNG pathway associated with differentially expressed genes between SRHIC and WRHIC purified CD8 T cells SOCS1 IFNG BAX AK2 IRF9 IRF1 JAK1 TYK2 PMC9674404__F3 Signaling condensates in the B cell receptor pathway SYK BCR COIL PMC8699740__F2 Integrin AE(CD103)B7 in Epithelial Cancer PLCG1 CCL3 CD69 HEL-S-28 ITGAE RUNX3 TGFBR1 PMC7069516__F14 Interrupting cyclic dinucleotide-cGAS–STING axis with small molecules TBK1 CGAS IRF3 PMC6426138__F6 Ciliary TGFB/BMP signalling SMAD1 SMURF1 DKFZp781O1323 SMAD2 CEP128 SMAD4 SMO TGFBR1 PMC8942302__F6 STAT3 pathway in cancers: Past, present, and future STAT3 EGF EGFR SRC PMC3423475__F9 Animal oral and veg1 ectodermal GRN for sea urchin embryogenesis GSC NODAL PMC4743530__F3 Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis MESP1 APC CTNNB1 PMC11050262__F14 Cytotoxic effect of cisplatin on the HT-29 cell line based on gene expression and pathway analysis BAD APAF1 PMC8166571__F1 Diet Regulation of Long-Chain PUFA Synthesis: Role of Macronutrients, Micronutrients, and Polyphenols on Δ-5/Δ-6 Desaturases and Elongases 2/5 ELOVL2 GLA FADS2 ELOVL5 FADS1 PMC9619038__F1 Editorial: Sirtuins and brain homeostasis SIRT3 NLRP3 IL16 SIRT2 SIRT1 PMC4997943__F2 CEACAM6 Signaling Pathway VTN CEACAM6 SRC PMC8016635__F3 Impact of PERK signalling activation on osteoclastogenesis NFATC1 ATF4 EIF2A RAC1 PMC8016635__F1 Brief diagram of the PERK signalling pathway INSR KEAP1 FOXO1 GCLC ATF4 MTOR EIF2A PMC11580516__F3 Key Mechanisms of Metabolic and Immune Modulation in the Tumor Microenvironment EGF IGF1 EGFR MTOR PMC8016635__F2 Downstream changes caused by activation of PERK on osteoblastogenesis FOXO1 NFATC1 ATF4 DDR2 DKK2 EIF2A RUNX2 CTNNB1 PMC3999173__F2 Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells LTA LTBR CXCL13 CCL21 AHR IL23R MYD88 PMC11580516__F4 Molecular Mechanisms of Breast Cancer Metastasis, Drug Resistance, and Target Organ Selection CXCL12 IL25 TSLP PIGF LOX IGF1 IL33 IL4 MMP2 MMP9 CCL2 IL1B PMC6039966__F3 The AhR genomic pathway AHR AHRR SRC PMC7599061__F1 Schematic process of the SARS-CoV-2’s internalization, proliferation in the cell, and influence on RAS TMPRSS2 ACE2 PMC8835793__F3 Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential RHEB MLST8 IGF1 IGF1R CTNNB1 PMC4507501__F1 New targets in cancer cell metabolism are shown PGAM1 HEL-S-26 PMC4392459__GA Propane synthesis derived from a fermentative butanol pathway is enabled by metabolic engineering HBD AHR PMC8466366__F1 Fungal Cell Wall Proteins and Signaling Pathways Form a Cytoprotective Network to Combat Stresses CDC42 MID1 CS PMC2075035__F4 Scheme of the LNB/GNB pathway in B GAL PMC5470086__F1 Intestinal FXR and TGR5 signaling in metabolic regulation CYP8B1 CYP7A1 FGFR4 CYP7B1 CYP27A1 PMC2075035__F2 Scheme of the Leloir pathway PMC7829888__F4 Alternative growth factor driven signaling pathways after androgen blockade STAT3 EGF PTEN IL6 JAK1 SRC PMC6516512__F1 Major steps in the catabolism of BCAA BCKDK PPM1K FASN BCAT2 BCAT1 PMC12034555__F1 Biogenesis of exosomes depends on two pathways ESCRT dependent and ESCRT-independent RAB31 LIMK1 EGFR ROCK1 TBC1D28 TSG101 CD63 CHMP3 TBC1D2B VPS36 VPS28 PMC1860592__F2 Biologic therapies: what and when? CD80 CTLA4 PMC12034555__F2 This figure shows the role of EV-associated proteins in TNBC progression through various molecular interactions: 1 CD44 CD24 EGFR ADAM10 CCL5 NOTCH1 PMC7565467__F2 Key components of the Ca2+signalling machinery in the control of cell proliferation and the cell cycle RB1 JUN ORAI1 STIM1 ARC MYC FOS PMC8809092__F7 Suppression of canonical TGFB signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis ME3 SMAD2 SMAD4 GATA4 PMC3594938__F5 Cell type-specific outcomes of KSHV interactions with CD36 and CD147 signaling pathways FYN CD36 LYN MTOR PMC12034555__F3 EVs derived from TNBC cells line can transfer various biomolecules to recipient cells, thereby modulated their biological functions FOXM1 STAT5B ANXA6 EGFR MSC BCL2 RAG2 NCL PMC4635569__F1 Proteins used in this study FH HEL-S-62p CFH PMC11512255__F6 Schematic model illustrates the mechanism by which HSV-2 UL24 blocks the IRF-3 signaling pathway TBK1 MAVS IRF3 PMC11580516__F1 Metabolic Reprogramming and Drug Resistance in Breast Cancer ACLY STAT3 GLS HK2 MTOR DEPTOR SDHC PMC6776918__F1 Mechanisms linking HPA axis dysregulation and AD CRH GC APP AVP PMC11580516__F2 Metabolic Reprogramming of Immune Cells in the Hypoxic Tumor Microenvironment IFNG HDAC1 STAT3 IL16 ARG1 CXCL2 HIF1A TNF PMC10308769__F1 First reported double drug–drug interaction in a cancer renal patient under everolimus treatment: therapeutic drug monitoring and review of literature RHEB MLST8 TSC2 RICTOR TSC1 ULK1 PTEN MTOR DEPTOR IRS1 PMC1852756__F2 The small nuclear ribonucleoprotein biogenesis pathway RAN TGS1 GEM PHAX PMC3608184__F1 Cardioprotective mechanisms of T3 HIF1A MTOR PMC8060499__F1 Possible involvement of the complement system (CS) in the recruitment of neutrophils and the formation of NETs in Alzheimer's disease CS CR1 PMC3837441__F7 The Cdc42-dependent regulation of neural differentiation in P19 cells CDC42 MTOR PAX6 HES5 PMC3722174__F8 Primary Respiratory Chain Disease Causes Tissue-Specific Dysregulation of the Global Transcriptome and Nutrient-Sensing Signaling Network RHEB TFAM TSC1 LARGE FOXO1 HIF1A NRF1 SIRT1 IRS1 PMC1914109__F8 The p110D → RhoA → PTEN signalling pathway described in the text HEL-S-62p PTEN SRC PMC4967210__F5 Ingenuity Pathways Analysis of the effects of TXNIP deletion CDKN1A TXNIP FASN KDR PMC5979596__F3A GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance CDK5 FYN PMC6391732__F3 Notch signaling pathway as seen in the KEGG database (hsa:04330) NUMB HES1 HES5 PMC7395689__F1 Figure describes the process by which AVB3 mediates prostate cancer cell metastasis SAMD5 SPARC CXCL16 MTOR SRC CCL2 RUNX2 CTGF PMC2453100__F7 The activated PI3K-AKT pathway and its downstream effectors that contribute to the tumorigenesis of TSHomas in TRBPV/PV mice BAD GSK3B MTOR CCND1 PMC11900819__S4 Proposed organization and role of adenosine receptors in mitochondria GSC PMC3022823__F9 FBPA clustering on gene expression in the bystander response KLF2 TNFRSF10C GADD45G HEL-S-62p RELB MEOX2 MYC FOXL2 NCOR1 CEBPD GDF15 IL11 CEBPB NFKBIZ CHIC1 CEBPE ZFP36 JUN IL12A SP1 VAV1 IRF3 PTGS2 CEBPA CDKN1A HOXB7 RELA TP63 MT1E NFE2L2 CREBBP EP300 KAT2B PMC3022823__F7 FBPA clustering on gene expression after direct irradiation TP73 KLF2 RELB MEOX2 PML SMAD4 MYC CXCL3 BTG3 ELF4 FOXL2 COX2 SP100 DKK1 NFKBIE AHR BATF3 HDAC2 CEBPB NOTCH1 NFKBIZ JUN CITED2 ETS2 EGR1 KDM5B IRF1 TAF4B CXCL2 IRF3 ERG ATF3 FOXO3A NAB2 RELA IRF2 BMP2 NRF DACH1 SERPINB2 MAP10 REL PMC4774109__F2 Dysfunctional humoral response during visceral leishmaniasis CD27 GC PMC8151274__F4 MiR-21 in the Cancers of the Digestive System and Its Potential Role as a Diagnostic, Predictive, and Therapeutic Biomarker CASP9 MSH6 DCC BAD MSH3 APC CASP3 SMAD4 PMC2997737__F1 AKT/MTOR pathway RHEB MLST8 TSC2 RICTOR MAPKAP1 TSC1 PTEN MDM2 PDK2 MTOR IRS1 PMC7982729__F4 Autophagy-mediated elimination of pathogens TBK1 CGAS TLR3 TLR4 TLR8 IRF3 IRF7 TLR7 TRAF6 PMC12021660__F2 Fat-body metabolic pathway profiling ACLY CTRL PMC8808015__F1 Wnt Signaling Pathway and ROR2 Receptor in Embryonic Development: An Update Review Article ROR1 CA12 APC ROR2 GSK3B LRP5 LRP6 DAAM1 PMC10040851__F6 Single-cell atlas reveals shared and distinct immune responses and metabolic profiles in SARS-CoV-2 and HIV-1 infections SYK PLSCR1 SOCS3 CNPY3 FYN CD74 WAS KIN PSME2 CD163 NMI SRI FITM2 SELL IRF9 HLA-DQA1 APC NAMPT IRF7 RNF213 EIF4E3 IFNAR2 MVP OGFR IFNAR1 CSK HLA-B HLA-C PSAP PPL MAX ADAR SLC25A28 ARHG TNFAIP3 HLA-DRB1 IFIT2 PSMA2 CNP POMP SLAMF7 PARP12 RIPK2 CSF2RB HLA-F IFITM3 GBP2 CMTR1 PARP14 PTPN1 TAF1 HLA-DMA SAMD9 STX7 LYN CD68 PS1TP5BP1 PMC9118092__F8 Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling MYL7 SLITRK4 TNFRSF12A GDF8 UCP3 CYP2E1 LTC4S FGF7B SRXN1 AQP8 WIF1 PMC9456318__F9 Integrated Analysis of Transcriptome and Metabolome Reveals Distinct Responses of Pelteobagrus fulvidraco against Aeromonas veronii Infection at Invaded and Recovering Stage KLF2 ATG12 BNIP3 CDK2 ATM PTEN MDM2 NLK SKP2 INS PMC9943254__F2 Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment BRD4 FH GLS FASN PDC SLC7A5 MYC HEL-S-26 PMC7459801__F1 Processing and trafficking of amyloid precursor protein (APP) through the endolysosomal pathway PSEN2 BACE1 APP PSEN1 PMC3979327__F3 MicroRNA networks regulate development of brown adipocytes HDAC3 MYF5 HOXC8 PMC7766831__F5 Proposed model of the molecular and cellular responses to new replication stress inhibitors ATR SSB PARP1 PMC5376429__F2 Emerging signaling pathways in HCC: chromatin remodeling: restricting transcriptional and DNA condensation occurs as a result of histone deacetylation catalyzed by HDACs in nucleosome LATS1 LATS2 TLR4 ARID2 NF2 PMC9943254__F8 Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment SUFU PTCH1 SHH SMO PMC11621776__F4 Important AM pathways FAS MALL MAL CIT PMC11621776__F6 Five signaling pathways associated with macrophage polarization which are highlighted by pink color IFNG GYS2 IL33 PMC2771360__F4 Microglia Are Mediators of Borrelia burgdorferi–Induced Apoptosis in SH-SY5Y Neuronal Cells GML BAX ATR PCNA GSK3B JMY CYC1 PTEN TIGAR CTNNB1 WT1 HIPK2 ATM PIGS SCO2 MDM2 CDK4 PMC4770774__F9 Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axis IGFBP5 MSC KLHL4 IGF1R PMC8710987__F3 Metabolic dysregulation in bronchopulmonary dysplasia: Implications for identification of biomarkers and therapeutic approaches FABP4 PMC11979968__F4 Distribution of the seven core targets in the serotonergic synapse signaling pathway and the drug‐pathway‐target‐disease network HTR4 EGFR CNR1 MMP9 SHE DDC PMC9553391__F8 Anlotinib Benefits the APDL1 Immunotherapy by Activating ROS/JNK/AP-1 Pathway to Upregulate PDL1 Expression in Colorectal Cancer JUN CXCL2 FOS PMC5452357__F4 Scheme showed the probably metabolic pathways in patient with PH2 and AGXT2 deficiency AGXT2 ABAT PC DAO PMC6522898__F10 Schematic illustrating the mechanism in which elevated HP induces apoptosis in RGCs through the regulation of the NGF signalling pathway NGF FOXO1 HP PMC6311083__F4 Qualitative Biological Regulatory Network (BRN) of Hexosamine Biosynthetic Pathway (HBP) intersection with PI3K-mTOR-Myc signaling and P53-MDM2 signalling axis OGA OGT FOXM1 MDM2 PMC7784512__F4 Schematic proposed mechanism of inflammatory downstream signaling pathway in lung epithelial cells undergoing hypoxia–reperfusion stimulation TLR4 IL1B MYD88 PMC4609742__F9 Model depicting the functional interplay between PPM1G, the 7SK snRNP, and ATM kinase during the activation of the NFKB transcriptional program in response to DNA damage MEPCE LARP7 PPM1G POLI ATM PMC9231409__F1 Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic Options TBK1 MAVS STAT2 IRF9 IRF3 NUP62 STAT1 TRIM25 TLR3 IFNAR1 NXT1 ISG15 TYK2 NUP98 PMC5512163__F2 Biologic and Clinical Perspectives on Thyroid Cancer tal-1 NTRK1 BRAF NTRK3 MTOR RET PMC5216790__F6 Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with Beta-catenin-dependent and Beta-catenin-independent signaling pathways ROR1 FZD2 WNT3A ROR2 LRP6 MYC CTNNB1 PMC9166437__F1 TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target TREM2 PLCG2 APOE PMC11130926__F1 Bacterial Q de novo and salvage pathways QTRT1 QTRT2 QNG1 PMC5512163__F3 Biologic and Clinical Perspectives on Thyroid Cancer EIF1AX BRAF TERT MTOR RET PMC6066558__F4 Soluble klotho pleiotropic functions and FGF23 – sKlotho interactions FGFR4 IGF1R TRPC6 FGF23 PMC11653467__F7 Poricoic acid A attenuates renal fibrosis by inhibiting endoplasmic reticulum stress-mediated apoptosis BAX ATF4 XBP1 PMC5395695__F1 Proposed mechanisms of pathogenesis in haploinsufficiency of A20 (HA20), otulipenia/otulin-related autoinflammatory syndrome (ORAS), and linear ubiquitin chain assembly complex (LUBAC) deficiencies SHARPIN TRADD OTULIN RIPK1 TNF TRAF2 PMC8468876__F2 Gamma-Aminobutyrate (GABA) Regulated Plant Defense: Mechanisms and Opportunities TH OGDH NADK PMC11149107__F1 HER3 targeted therapies in the clinic and HER3 downstream signaling pathways EGFR PTEN IGF1R GRB2 MTOR SRC PMC8466973__F1 High temperature requirement A1 in cancer: biomarker and therapeutic target EGF EGFR PAX2 NOTCH1 PMC8990718__F6 Serum amyloid A 1 induces suppressive neutrophils through the Toll‐like receptor 2–mediated signaling pathway to promote progression of breast cancer SAA1 MYD88 PMC4770016__F2 ITK acts as a rheostat for the TCR signaling pathway ZAP70 CD69 ITK IRF4 LCK PMC11594203__F6 Differentially expressed genes related to mammary epithelial cell proliferation and milk protein synthesis in the PI3K-Akt, WNT, and mTOR signaling pathways after knockdown of S100A9 in MAC-T cells CDC2 LRP6 MTOR LAMTOR2 DEPTOR TSC2 FOXO3A TLR4 CDK2 DVL3 S100A9 CCND1 SLC36A1 PMC7934064__F2 Mechanisms involved in DDR and checkpoint immunotherapies ATR CGAS CHEK1 ATM CCL5 PARP1 PMC7352439__F2 Metabolic characteristics of M1 and M2 macrophages FAS IL13 IL4 HIF1A IL6 PMC12210716__F1 Jak-STAT signaling pathway STAT1 IFNGR2 IFNGR1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC5845129__F1 Schematic diagram for innate immune response against influenza A virus (IAV) infection MAVS TLR3 IRF3 IRF7 TLR7 TYK2 MYD88 PMC6073271__F1 Simplified diagram of the 2-C-methyl-d-erythritol-4-phosphate (MEP) pathway for phytohormone abscisic acid (ABA) biosynthesis with components occurring in the Chloroplast and Cytosol IPP HEL-S-62p PMC8710987__F1 Metabolic dysregulation in bronchopulmonary dysplasia: Implications for identification of biomarkers and therapeutic approaches HEL107 RPE ASL RPIA F2 HEL-S-162eP HEL-S-5 PMC6032434__F6 Summary and model for the potential function of the chIL-34 signaling pathway SOCS1 STAT3 STAT1 MAP3K7IP1 PMC4086483__F1 NFKB signaling pathway CD40 HEL-S-92n BCR PMC9248717__F2 Wnt Signaling in Postnatal Tooth Root Development CA3 JUN ARHA RAC1 PMC9248717__F1 Wnt Signaling in Postnatal Tooth Root Development APC LRP5 LRP6 CTNNB1 PMC7878563__F6 Signaling pathways coupled to the M4 mAChR ADRBK1 GSK3B PMC7878563__F5 Signaling pathways coupled to the M1 mAChR ADRBK1 GSK3B ARHA PMC7192886__F1 Immune responses induced by radiotherapy IFNG HMGB1 ATR CGAS TLR4 EGFR IRF1 ATM PMC6585493__F2 Transcriptional changes of genes involved in fatty acid catabolism, MVA formation, and energy metabolism by ΔYPL062W, whose reactions mainly occur in the peroxisome (A), cytoplasm (B), and mitochondrion (C), respectively IPP IDI1 POT1 PMC9630645__F3 Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives TG TNC SPR TRPV1 TNF PMC5671379__F1 Damage Associated Molecular Patterns in the Pathogenesis of Osteoarthritis: Potentially Novel Therapeutic Targets HMGB1 S100A8 TRAF6 S100A9 PMC9628128__F1 Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications EGF F2 HK2 EGFR APC PTEN HEL-S-30 MYC KRAS CTNNB1 PMC6346072__F1 Metabolism of sulfur amino acids and H2S synthesis HEL-S-182mP PMC7404291__F4 HSV-1 evasion mechanisms to downregulate the host innate immune response STAT1 CGAS MAVS STAT2 IRF9 IRF3 IRF7 TRAF3 JAK1 TRAF6 TYK2 MYD88 PMC8595937__F1 Bruton’s Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures CDC42 CFL2 ZAP70 ACTG1 CXCL12 NCK1 PXN JAK3 VAV1 RHO RAC1 HEL114 CRK BTK FYN PAK1 ROCK1 RAP1A CSK ITK TLN1 PLEKHG2 CXCR4 PMC7120249__F1 Immune-related autophagy functions ATG16L1 TLR4 IRGM NOD2 IL1B PMC5512069__F8 The role of BMP4 in regulating hyperandrogenism development SMAD1 DKFZp781O1323 CYP17A1 BMP4 SMAD4 PMC10838060__F6 cGAS-STING and pyroptosis TBK1 GSDMD NLRP3 AIM2 IRF3 PMC10838060__F7 cGAS-STING pathway and metabolic reprogramming PDK4 ACOD1 PDK2 PMC10838060__F4 Other media for activating STING TBK1 CGAS PRKDC IFI16 IRF3 TRAF6 PMC10838060__F8 cGAS-STING and cell senescence in diabetes FANCD2 TBK1 CGAS MRE11A TREX1 PMC10838060__F9 CGAS-STING pathway in diabetic complications TBK1 CGAS NLRP3 PMC6684391__F6 Proposed interaction induced by azithromycin (AZM) is depicted IFNG STAT1 TLR4 RELA IL6 JAK1 TYK2 IL1B MYD88 PMC8830521__F4 Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer RPL5 STAT3 BAX NLRP3 PCNA MMP2 PTEN MMP9 MTOR IL1B PMC5606204__F4 Regulated Cell Death Pathways RIPK3 CASP9 CASP8 CASP4 CASP3 APAF1 CASP10 FADD PMC2812385__F7 Alternative mechanisms exist for the induction of inflammatory and apoptotic genes in the absence of the IFNA/B receptor during influenza virus infection NOS2 EGR1 JUNB RELB PML IRF1 IRF7 MMP9 MYC CCL2 STAT1 HOXA13 FOSL1 MGP CASP4 RELA BMP2 MDM2 ING1 EIF2AK2 IL1B PMC5426484__F3 Network fabricated in CellDesigner BDNF DAO RET CRTC1 PMC1851974__F2 Regulation of cyclin D1 degradation TF FBXW8 CDK6 GSK3B DYRK1B CCND1 CDK4 PMC8830521__F5 Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer TF BAX METTL14 PMC8830521__F6 Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer COX2 PHLPP2 SMO MYC CTNNB1 PMC3789860__F3 Shaping neurons: Long and short range effects of mature and proBDNF signalling upon neuronal structure TRIO ARHA BDNF PMC3582714__F1 Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function RHEB TSC2 RICTOR TSC1 HIF1A MYC PMC5945848__F8 P2RX7-MAPK1/2-SP1 axis inhibits MTOR independent HSPB1-mediated astroglial autophagy P2RX7 MAPK1 COMP SH3GLB1 SP1 ULK1 HEL-S-102 GSK3B PRKAA1 PMC4396872__F1 Canonical and noncanonical NLR inflammasome activation STAT1 TNF IL1B PMC5627515__F3 Protein-bound uremic toxins could take use of five potential toxin-conjugated albumin-receptor pathways to either promote or suppress inflammation CDC42 SPARC ARHA SRC PMC4396872__F3 NOD signaling pathways MAVS TAB3 NOD2 IRF3 IRF7 TRAF3 PMC9475348__F6 Human placental mesenchymal stem cells regulate inflammation via the NF‑KB signaling pathway BAX TLR4 IL1B PMC12032003__F7 Working model of G-Rg1’s functions in protecting the synaptic plasticity and mitigating neuroapoptosis via the Hippo-YAP signaling pathway in the stress model LATS1 LATS2 TEAD2 TEAD3 TEAD4 PMC8471828__F6 Ferroptosis Meets Cell–Cell Contacts LATS1 LATS2 FACL4 PMC4206829__F4 Recent advances in understanding colitis-associated tumorigenesis STAT3 TLR4 CTNNB1 PMC10788715__F5 MiRNA-766-3p inhibited gastric cancer via targeting COL1A1 and regulating the PI3K/AKT signaling pathway COL4A4 COL6A1 COL1A1 COL4A3 LAMC2 COL4A6 COL4A2 COL4A1 LAMB2 LAMA4 COL2A1 PMC9456412__F2 Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder COX1 COX2 PMC4543753__F4 Transcriptional gene regulatory network in VBL-treated KB-3 cell ACTG1 PSMD11 RAB31 KRT14 SPHK1 SDC4 HEL70 AKR1B1 PSMD1 EMP1 CDKN1A NFKB1 RELA PLP2 CD63 MAGED2 PMC6249341__F1 Implication of microglia in the development of Alzheimer's disease TREM2 NLRP3 TLR4 CD33 APOE APP IL1B PMC7737398__F9 Pathways of ES and SR PMC9495382__F2 p53: From Fundamental Biology to Clinical Applications in Cancer ATR CDK6 ATM CDK4 PMC4534355__F5 Distilling a Visual Network of Retinitis Pigmentosa Gene-Protein Interactions to Uncover New Disease Candidates UBC PRPF4 RPLP0 AMOT OFD1 HEL2 CP PMC4390248__F5 Representative protein-protein interaction networks of key pathways and proteins involved in sperm functions HEL-S-99n PPIB HEL-S-133P CLU PMC7868042__F2 Autophagy in kidney homeostasis and disease FAT10 NBR1 PINK1 BNIP3 BNIP3L FUNDC1 PMC10967382__F5 Altered sphingolipid metabolism and signaling in monocytes and neutrophils during pneumonia UGCG ACER1 RAF1 SGPL1 SGMS1 SPTLC3 SPHK1 AKT3 SGMS2 SMPD1 TRAF6 ABCA1 MYD88 SPNS2 TLR1 SPTLC2 NLRP3 TLR4 PC BCL2 SPTLC1 ACER3 PMC8267750__F4 Fructose and the Liver NLRP3 IL1B MYD88 PMC8714903__F2 Impact of Bartonella VirB/VirD4 Type IV Secretion System Effectors on Eukaryotic Host Cells STAT3 ARHA PMC4445861__F2 Slit/Robo interactions and their roles in carcinogenesis CDC42 DCC HGF SLIT2 PI3 GSK3B MMP2 GRB2 MMP9 CXCR4 SLIT1 CTNNB1 PMC12037536__F5 Multiple cytokines and signaling pathways in psoriasis is highly significant STAT3 IL17RC TRADD SMAD2 MAL TRAF3 TRAF6 IRAK4 MYD88 IFNGR2 IL17RA IL17RB STAT4 TYK2 IMPACT PMC8727737__F2 JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance PTPRT MTOR PMC4024059__F1 STAT3 and epithelial–mesenchymal transitions in carcinomas STAT3 EGF OSM OSMR EGFR SOCS3 PMC3681753__F8 Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses TMEM140 SLC29A4 ATP2B3 TANK MC2R TRAF3 TRAF6 PSMD2 CTNNB1 MED12 NTF4 ORMDL3 HAL POLR2A FCGR3B ARHH TNK2 TFR2 CASP8 SMS HSFY2 NEU3 SLC38A12 APC ZFY PCDHB2 VWA2 PSMC4 THEM5 PLEKHH1 TRIM25 SSH3 MBD3 PKD2L1 CASP10 FADD PMC8313795__F1 Chitosan derivatives: A suggestive evaluation for novel inhibitor discovery against wild type and variants of SARS-CoV-2 virus TMPRSS2 FURIN ACE2 PMC6687759__F3 Proteoglycans in cancer-predicted pathway CBL EGFR HEL-S-11 VEGFA MYC DCN PMC5878997__F3 Extranuclear Signaling by Sex Steroid Receptors and Clinical Implications in Breast Cancer TF EGF SP1 EGFR HBD CDK2 GRB2 SRC PMC7559203__F3 KSHV-deregulated NFKB signaling pathway in oncogenesis STAT3 LAT BCL2 EZH2 IRF4 CXCR4 RAC1 PMC7559203__F1 an overview of virus-deregulated NFKB signaling pathway in oncogenesis RELB KL BCL2 ID1 PMC7559203__F2 EBV-deregulated NFKB signaling pathway in oncogenesis SYK LAT GC SMAD4 LYN PMC2949129__F7 Putative signaling pathways leading to translational activation and enhanced MCT2 protein synthesis after BDNF treatment in cultured cortical neurons MTOR BDNF EIF4E PMC8964062__F1 T Cell Metabolism in Infection RHEB CD80 TSC2 FOXO1 HK2 MYC PMC8450894__F2 Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ TLR4 CD14 PMC9132726__F1 Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium SUFU SHH SMO GLI3 PMC4563137__F5 Pathway enrichment analysis reveals PI3K/PTEN/AKT signalling and apoptosis pathway as the most significantly related pathway ITGB1 SHC1 SOS1 PDPK1 CDKN1B PIK3R1 HEL-S-28 PTEN GRB2 PMC9132726__F2 Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium GPR161 SMO AKAP9 PMC6777507__F2 Activation of serotonin receptors (5-HT-R) initiates a signaling cascade that leads to the activation of extracellular signal-regulated kinases (ERK) APP BDNF PMC9132726__F3 Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium GPR161 FAS SMO PDE4D ANKMY2 ARHGAP36 PMC4619565__F7 Parallel activin and TGFB signaling in advanced colon cancer TGFBR2 ACVR1 SMAD4 TGFBR1 PMC6850218__F1 Model illustrating 4 potential roles of RGD-binding integrins in the initiation, development, and perpetuation of organ fibrosis SMAD2 TGFBR3 SMAD4 PMC5527674__F1 “Pushmi-Pullyu” of DNA REPAIR: Clinical Synthetic Lethality TOPBP1 ATR RAD51 BRCA1 WEE1 CHEK2 CHEK1 ATM PARP2 MDC1 PARP1 TP53BP1 PMC7823564__F1 NFKB canonical and non-canonical pathways LTB CD40 EGF LTBR EGFR RELB PMC8247594__F2 Evolution of Our Understanding of XIAP Deficiency MAP3K7IP1 RIPK2 BCL10 PMC8247594__F3 Evolution of Our Understanding of XIAP Deficiency SYK TAB3 TNF RAC1 CAP2 RIPK3 MAP3K7IP1 NLRP3 TLR4 IFNAR1 NOD2 DAP CAP1 TRAF2 FADD PMC8306787__F3 Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance FAS LOXL2 CRTC2 IL18 ATF4 EGR2 PMC3819805__F11 Folate biosynthetic pathway in Plasmodium falciparum DHFR DHPS PMC7167343__F1 Androgen metabolism scheme TG UGT2B15 UGT2B7 UGT2B17 PMC8686808__F2 Risk surveillance and mitigation: autoantibodies as triggers and inhibitors of severe reactions to SARS-CoV-2 infection TF VWF CIC APC MPO PMC2617762__F6 Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia KEAP1 PGAM5 MAF PMC8306787__F4 Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance FAS LOXL2 NR2A1 CRTC2 PC ATF4 PMC7847180__F8 Network analysis ARHGAP5 EGF NECTIN2 AFDN FCGR3A ARHA MB ARHGAP12 TGFBR1 PMC2866107__F5 Current Status of Xenotransplantation and Prospects for Clinical Application TF VWF TFPI APC PMC8120744__F4 Upregulated anti-angiogenic miR-424-5p in type 1 diabetes (model of subclinical cardiovascular disease) correlates with endothelial progenitor cells, CXCR1/2 and other parameters of vascular health CD40 VEGFC CXCR1 INSR COX2 IL8RB VEGFA CCND1 PMC4211615__F1 EMT-associated signaling molecules in glioma cell CD44 STAT3 EGF TNC HGF EGFR CXCR4 PMC6994339__F1 Filtering through the role of NRF2 in kidney disease RBX1 KEAP1 GCLM NQO1 GCLC PMC6955051__F3 Role of interleukins in heart failure with reduced ejection fraction TH IL33 IRAK2 VCAM1 MYD88 PMC8236958__F6 Identification of Regulatory Functions of LncRNAs Associated With T. circumcincta Infection in Adult Sheep CD44 GAL RHO SRC PMC2736291__F2 Diagram shows the cell signaling pathways, which were involved in postconditioning BAD GSK3B PTEN CTNNB1 PMC6681682__F2 Functional networks overrepresented in the list of DE mRNA in response to infection of bMDMs with Streptococcus agalactiae strain ST103 compared to uninfected controls HMMR FMNL2 GIMAP4 PNKD CEP170 MYCBP CEP97 ARL1 CNTRL ARL11 VASN NNT MXI1 IL9 HEL-S-134P PAPSS1 EMILIN1 NMI CETN3 GAL AGO1 ID2 CEP131 HUNK ARL8B IGSF8 IFT74 NHSL2 SGSM1 SPINT1 PTTG1 AGO4 CACHD1 TNRC6B ARHGDIB RAB19 B9D2 SDCCAG8 MICAL2 RP2 PLCB2 TOX IGSF6 TM4SF1 IL23A UNC119 C9orf72 PMC11655346__F1 Unique role of DLL3 in the notch signaling pathway ASCL1 ADAM10 DLL3 RBPJ PMC8005123__F2 Molecular pathways of SMC-mediated migration and proliferation HES2 CX3CR1 GC HES1 HES5 PMC2924816__F1 Quantification of Beta-Catenin Signaling Components in Colon Cancer Cell Lines, Tissue Sections, and Microdissected Tumor Cells using Reaction Monitoring Mass Spectrometry CD44 MMP7 APC GSK3B AXIN1 CSNK2A1 CCND1 AXIN2 CTNNB1 PMC6826333__F1 Network of Beta-elemene-target genes GDF8 GPHN CANX OXTR HIF1A HCN4 KCNA1 KCNA3 KCNB1 NPTX1 LCT DRD1 ALDH1A3 DRD2 INHBA FYN SHANK1 HEL-S-20 HEL-S-29 HEL-S-5 HCN1 MMP3 CYGB KCNMA1 MIP AHCYL1 REST P2RY11 ERAF APOE SNCA RAPGEF2 PALM IGF1 PLCB1 APIP MTR MAT1A GNA13 NR1C2 CRTC1 AMD1 RAPSN HPCA GUK1 GLRA3 CLU KCNB2 DPP4 APP ADH1C ACHE HEL-S-117 IL10 FEN1 LRRK2 SOX15 EIF2AK1 OPRM1 DIO1 KCNJ10 CKMT1B KCNK18 USP2 SPTBN4 STX7 SAMTOR SCN3B CFTR GJC1 ACY3 KCNC1 KCNC4 SDF4 KCND1 HEL-S-1a KCND3 PPARG NCMAP GNRH1 TNNI3K KLHL41 UGT3A2 LRRC4B CEP112 CARD11 CNTNAP1 NETO1 LRRTM1 CNGA1 MTRR HEL-S-4 RNF207 SIRT2 CNGB1 ZP4 TSEN34 NLGN1 GNAS NLGN2 ACSS2 NRXN2 NLGN4Y SORCS3 TPO PKLR OXT RYR2 ID2 SNX3 DSC2 PICALM WLS SLC24A1 CRLF1 CDK2 GPX7 DLG2 TET2 FAS HEL-S-62p MC3R UHMK1 TSEN2 MEF2C OLFM1 CCND1 KLHL17 CDK4 JUP SLC18A1 TRPM7 STAR ENTPD6 LDB1 MED1 FBP1 NTRK1 PTH UNC119 BGLAP PINK1 CYP2E1 KCNA4 GNAT2 ARF6 ZP3 EPO GLRA1 KCNE2 AUTS2 PAX7 MAOA ASPA INHA CCNE1 CKMT2 ICMT CHRNB2 CNTN2 GAD2 STX1A GHR HEL-S-44 CRHBP KCNC3 UBQLN2 HAO1 DAB2IP DLG4 AHCYL2 AQP8 RELN NRXN3 NPY2R EDN1 PRKAG3 RAB1 CASQ1 PRKAB1 MPP3 AQP1 SYT9 ERCC1 CXCL12 LEP CD36 CRH KCNK4 GPX1 KCNA2 SHANK3 GLRB SYT7 DAGLB HEL-S-182mP HRC SNAPIN IL18 PPARGC1A CASK TSEN15 MYOD1 THBS1 KCND2 ARRB2 HEL-S-67p PKP2 DSG2 ARG1 HEL-S-30 ARX ADH7 EPB42 NPPA TRPA1 SCN2A NFIB RS1 ALDH1A2 ADA PRMT1 STXBP1 SLC17A7 ARF1 PRKCZ ATOH8 FBXO32 ADH1A SLC4A10 PAH HCN2 EDN3 APOC1 CARF DUOX1 DUOX2 ALAS2 ACSS1 KCNK3 BMP6 ADH6 BHMT2 ERCC5 MTMR4 ERMN ChAT FGA ALDH3B1 KLF4 TH MC1R HGF ERCC2 FOXE1 SHANK2 RER1 PRKAG2 SRPX2 PTEN ATXN2 TNR MRI1 DUOXA2 SCN10A KCNC2 ALDH2 KCNK2 DAGLA PRKCE KEL CNGA3 CIDEA SYP F2 PDE3A KCNAB1 CARTPT IL1B HEL2 CAV2 MT3 CACNG2 CD14 PTPN11 ATP1A1 FECH HMBS ENSA CPOX MAGI3 AGER PEMT MAP2K1 GJA1 TRAF2 FADD SLC24A3 PMC6826333__F2 Network of pancreatic cancer-target genes STAT3 PIK3CA RAF1 CCK SMAD2 PIK3R1 SMAD4 BNIP3 HIF1A CD133 CCNA2 PLK1 CCL2 KRT19 FGFR2 MAPK14 IFNG CDX2 BCL10 SHH SMO FLT1 KDR ABCB1 GRPR LPL ARHH MMP7 CASP9 RAD51 SP1 APC HSD11B1 CTLA4 IL1A TNF IRS1 ERBB3 CCL24 IGF1 CDKN1A IL1RN ABCC8 BCL2 TF STK11 PGR TNFRSF1A GAD1 IL2RA TERT TGFBR1 CCKBR AFP MUC1 IL10 KIT DPYD ARHA KRAS RAC1 MKI67 CCKAR NR2A1 MUC2 DDIT3 CFTR ERBB2 TNFSF10 PPARG MST1R TYMS GNAS TFF2 HMX1 MUC6 RIT2 LOX MDM2 FHIT SRC PKLR S100A4 ROS1 TNFSF6 PLAUR VEGFA HRAS MIA GHSR INSM1 EPGN CDKN1B CDK2 OCIAD2 CDKN1C HFE FREP1 CXCR4 RET FAS ENO2 MSLN BRAF SFN INS NCAM1 PDX1 ATM CCND1 CDK4 CDC2 JUN GDNF CTRC PTGS2 CD55 MMRN1 PARP1 GCG CROP HMGA1 NTRK1 MUSK ABCC1 MCL1 MYC PSEN1 RB1 BIRC5 SOX9 ALOX5 PI3 FGFR1 BTC POMC PC KRT7 F2RL1 PSCA NOTCH1 HEL-S-44 NR1i1 MAPK1 DCD NOS2 CASP8 AIP GSTM1 NT5E SSPN ENO1 LCN2 BAK1 HNF1A CXCL12 TGFA TGFB1 CD36 PCNA IGFBP1 GH1 FOXM1 PAP USP4 THBS1 RRM1 PTPRN HEL-S-89n IL4 HEL-S-30 IGF2 NR3C2 PSMD9 MEN1 PDGFRA NFKBIA PRSS1 CALCA KRT20 CGA SPINK1 SCTR SSTR5 SPARC GHRL SKP2 IAPP BCL2L1 NGF HLA-E FGFR4 WNT1 GCK VIP HK2 SERPINA1 SLC2A2 KLK3 COX5A FOS PTHLH BRCA1 APEX1 MUC4 BDNF CP GLP1R EGF HEL113 MMP14 BAD HGF PDAP1 COX10 EGFR CD82 IGF1R PTEN MTOR PSMD1 CTNNB1 LSM1 PLAT SYP RIPK1 IL2 ABCG2 IFNA1 IL1B CRP BAX HMGB1 EGR1 HEL-S-7a PTPN11 IL6 BCL2L11 CD34 FGF2 CD44 CTNNBIP1 ITGB1 NFKB1 CASP3 HDAC9 MAP2K1 PMC7096354__F4 Dysfunctional pathways of miR-15a and miR-24-1 SFRP5 SIK1 KRT33B RUNX1T1 PMC7074686__F1 Interplay of different signalling pathways that enable C OGT PMC8870141__F5 Sympathetic Nerves and Innate Immune System in the Spleen: Implications of Impairment in HIV-1 and Relevant Models TH ChAT TNF PMC8201093__F2 Role and Clinical Implications of the Retinoblastoma (RB)-E2F Pathway in Gastric Cancer ATAD2 E2F2 E2F4 E2F3 SPIN1 PMC8870141__F2 Sympathetic Nerves and Innate Immune System in the Spleen: Implications of Impairment in HIV-1 and Relevant Models TLR3 CCR5 PDC IRF3 CXCR4 PMC5916970__F1 NFKB/Rel and MAPK pathways activation STAT3 TRADD TRAF1 TRAF3 TRAF2 PMC5267440__F1 Molecular regulation of macroautophagy and targets for pharmacological stimulation of the autophagy-lysosomal pathway TSC2 ULK1 TFEB BCL2 PMC3048459__F3 TGFB Smad-dependent signaling pathway: TGFB exerts its effect by binding and activating type II receptor (TGFBR2) and then type I receptor (TGFBR1) TF SMURF1 SMURF2 TGFBR1 PMC5634336__F2 The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention STAT3 JAK3 EPO TPO STAT4 JAK1 TYK2 PMC6743726__F2 Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis HEL-S-61p PMC4905414__F1 Simplified model for phosphatidylserine receptor-mediated efferocytosis SYK CD300A CD300LB CD300LF PMC6480582__F7 Graphic summary for nifedipine-induced lipogenesis on renal tubular cell ACSL1 NR1C1 HMGCR CD36 NDP PMC11915795__F9 Proposed model for SVV antagonizes type I IFN signaling by targeting HDAC4 IRF3 OAS1 PMC5021219__F1 MOLECULAR PATHWAYS: JAK/STAT PATHWAY: MUTATIONS, INHIBITORS, AND RESISTANCE SOCS1 PMC6443324__F2 Modulatory mechanisms of TRAIL extrinsic signaling pathway by E3 ligases and deubiquitinases MKRN1 BAX PAF1 ITCH USP2 RIPK1 APAF1 TRAF2 FADD PMC6877906__F1 MyD88-dependent and TRIF-dependent TLR signaling pathways TIRAP CD36 TAB3 TLR9 CD14 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 BTK MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC8107079__F9 CircPVT1 up‐regulation attenuates steroid‐induced osteonecrosis of the femoral head through regulating miR‐21‐5p‐mediated Smad7/TGFB signalling pathway BAX COL1A1 CTSK BCL2 ACP5 PMC6877906__F2 Proposed model for the role of TLR-mediated innate immune events in regulating the Th1/Th17 and Th2 immune balance MAVS TLR3 TLR4 PDC TLR8 PMC6940522__F5 Resveratrol downregulates miR-31 to promote T regulatory cells during prevention of TNBS-induced colitis SOCS1 LTBP1 SOCS3 PMC2713123__F6 Early- and late-phase platelet aggregation regulated through PAR1 HEL164 PC RHO LPP PMC10139073__F2 S1PR function in osteogenic cells S1PR1 S1PR3 COX2 S1PR2 SPHK1 RHO RUNX2 CTNNB1 S1PR4 PMC10139073__F3 Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone S1PR1 S1PR3 COX2 S1PR2 SPHK1 GSK3B CTNNB1 PMC8064175__F5 Sex-specific differences of humoral immunity and transcriptome diversification in older adults vaccinated with inactivated quadrivalent influenza vaccines CRP FITM2 SERPING1 C1S C1R IFIT1 IFITM1 IFIT3 C1QB IRF7 C4A VSIG4 TYROBP C1QA IFITM3 C1QC MX1 C4B_2 PMC5998874__F3 Hypotheses of dysfunctional regulation mechanisms of gastric carcinogenesis around XBP1 PPP1R1B STAT3 FKBP11 BCL2 ATF1 GATA6 MTOR SRC CXCR4 CA9 XBP1 PMC8000263__F1 Ferroptosis signaling pathway POR GPX4 LPCAT3 FACL4 HEL-S-34 ADA PMC3408426__F10 Metabolic genes regulated by the Met TFs PGS1 ACO2 PC HEL-S-26 PMC10838060__F2 cGAS-STING pathway and the NFKB pathway TBK1 TRIM5 TRIM32 ULK1 ATM TRAF6 PMC8000263__F2 Lipid metabolic pathways that regulate ferroptosis ELOVL2 ACSL3 CD36 GPX4 FASN LPCAT3 FACL4 GLA FADS2 ELOVL5 FADS1 HEL-S-34 TNLG7C ADA PMC10838060__F3 cGAS-STING and JAK–STAT pathways SOCS1 TBK1 CGAS USP18 IRF3 SOCS3 JAK1 RNASE7 TYK2 PMC9208136__F1 Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli IPP MVD MVK PMC5017307__F1 Hedgehog signal transduction: key players, oncogenic drivers, and cancer therapy ADRBK1 EVC2 EVC GPR161 KIF7 SUFU PTCH1 SMO PDE4D INPP5E PMC2943291__F6 Proposed scheme of the molecular mechanism underlying LPCAT2 activation LPCAT2 TLR4 MYD88 PMC10838060__F1 Molecular mechanism of the cGAS-STING pathway TBK1 TRIM32 TRIM56 STIM1 TLR4 TLR9 IFI16 TRAF3 TRAF6 PMC3205057__F6 Influence of miR-300 on apoptosis pathway BAD FAS TRADD FADD PMC3205057__F8 Effect of miRNAs on cell cycle, proliferation, and differentiation MOV10 RAN THBS1 IFRD1 RBL2 RUNX2 UGT8 S1PR1 NR1C1 INHBA CDK7 CCNE1 CCND2 AURKB BNIP2 E2F3 TP63 PXDN JAK1 TWEAK PMC5347721__F1 Hormonal receptors in lung adenocarcinoma: expression and difference in outcome by sex SRY TBP SRC PMC6089764__F3 Interaction network of paeonol and known gastric cancer genes TNFRSF1A CXCL8 TNFRSF10A TGFBR2 RTN4R STYK1 PGA5 IL2 DCN IL1B CDH17 CASP8 LCP2 NGFR DSG2 IL17A PTGS2 SLC6A2 ESRRA LTB PDK4 TSC1 CASP3 ERBB2 CFTR VCAM1 CASP10 M6PR PMC6854620__F7 Running young is more effective than running at midlife LAMA5 MMP14 LAMB2 LAMA4 VEGFA NOTCH1 PMC3901350__F1 Noncoding RNAs in DNA Repair and Genome Integrity ATR RAD50 MRE11A BRCA1 RNF168 H2AX RNF8 ATM MDC1 PARP1 PMC6370266__F1 LPS-TLR4 activates the NFKB signaling pathway TLR4 TRAF6 TNF IL1B MYD88 PMC4317864__F5 Schematic representation of the mechanism for UCA1-regulated metabolic switch STAT3 HK2 MTOR PMC4048575__F5 Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival HEL-S-8a KEAP1 MAF PMC7801696__F6 LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma RAD50 ATRIP EGFR ATM PMC4048575__F1 Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival ATG101 ATG10 ATG3 ATG12 UVRAG ATG5 PMC11053886__F2 Signaling related to flowering PRR9 ELF4 CRY2 PRR7 ELF3 PMC8201163__F1 Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications NR1C1 HMGCR TLR4 FASN ACACA TNF GPX1 IRS1 PMC9700203__F7 Chromosome-level genome assembly for Dracaena cochinchinensis reveals the molecular basis of its longevity and formation of dragon’s blood MYB PRX PMC5364265__F8 Putative transcription factor network for estrogen signaling FOXM1 E2F4 E2F6 SOX2 E2F7 TFAP2C PMC9353721__F4 Analysis of Protein–Protein Interactions Identifies NECTIN2 as a Target of N,N-Bis (5-Ethyl-2-hydroxybenzyl) Methylamine for Inhibition of Lung Cancer Metastasis CDC42 LMO7 FYN FER INSR SMAD4 ARHA NLK OTP PMC7654589__F2 Canonical PINK1/PARKIN pathway PINK1 PARL VCP PMC4012261__F6 Graphical representation of the genomic neighborhoods of SRF and ZNF350 RASSF2 ATR PXN SPARC PTEN SAMD11 SMPD1 LAMC1 FLNA PLEK ACTA2 PLAGL1 CCNE1 tmp_locus_29 RASAL1 ATM SPEG LPP DCXR SP1 PARVA ACADS ZNF367 S100A6 HEL-S-28 NCOA1 PRRX1 DKFZp686P11128 KCNN2 ZNF350 EPPK1 PMC3094296__F1 KEGG pathways used for the influence approach CXCL9 CXCR3 TBK1 CXCL5 CXCL1 CXCL2 IRF3 B2M IL6 TRAF3 CXCL6 CXCL10 RAC1 CXCL3 CXCL11 STAT1 TLR1 MHC2TA TLR3 IL1B PMC7375892__F5 Affected Local Networks by RB1 and TP53 Inactivation Events ZAP70 AURKA RFC4 SYK RFC2 BUB1B MYBL2 ZWINT PTPRC PLK1 FANCC RB1 FANCD2 CDKN2A CCNE1 NCOR1 USP1 MDM2 POLE SRC HDAC2 NOTCH1 MSH6 MSH2 RAD51 CHAF1B TFDP1 INPP5D EZH2 TUBG1 PRIM1 HAUS1 RPL3 DDB2 POLA1 CDKN1A BRCA1 AURKB MCM3 HSPA4 CALM1 CDK2 MCM6 CENPA MCM2 ASF1B FAS DSCC1 CDC20 PCNA EGFR STK4 CDT1 BLM HEL25 CCNG1 BTK CDKN2C PRC1 CDCA8 CCNB1 CCND1 GPS2 DNMT3B CDC2 FEN1 NUF2 RPL11 KNTC2 PTPN6 RPA1 GMNN HDAC1 CCNE2 CHEK1 RPL26 LCK PMC4868692__F8 Triptolide induces protective autophagy through activation of the CaMKKBeta-AMPK signaling pathway in prostate cancer cells TSC2 ULK1 HEL-S-29 MTOR ATG5 PMC6694711__F2 Renin-angiotensin system and its bypass loops and converging signaling pathways can be targeted at different points COX2 CTNNB1 PMC7310559__F8 CYT997-induced apoptosis in GC cells STAT3 CCND1 PMC10495336__F6 Working model of the oncogenic potential of SGG UCN34 PDPN EGFR PDGFRA HEL-S-28 MTOR CD34 PMC3132641__F3 Proposed mechanisms mediating the effect of the (pro)renin receptor (PRR) in metanephric kidney development SELL EGFR LRP5 RET CTNNB1 PMC6738049__F1 Illustration summarising the major tumour procoagulant effects in pancreatic cancer TF PDPN HPSE TFPI PMC6738049__F2 Haemostasis and fibrinolysis TF TFPI PLG PSCA PMC8833084__F5 Combined Proteomic and Metabolomic Strategy for Allergens Characterization in Natural and Fermented Brassica napus Bee Pollen FBP2 FBP1 GHB2 PMC10383317__F3 Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children SIM1 GHSR LEPR NTRK2 NPY AgRP SH2B1 BDNF PMC7674197__F1 TLR signaling and the endogenous DAMP pathway in systemic JIA and AOSD HMGB1 NLRP3 TLR4 S100A8 IRAK1 IRAK2 TLR7 TRAF6 S100A9 IRAK4 IL1B MYD88 PMC8636938__F2 Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries AHR MTOR PMC7522371__F4 TGFB signaling pathway TGFBR2 SMAD2 SMAD4 TGFBR1 PMC6803483__F1 Metabolic pathway of linoleic and arachidonic acid LTB LPA LTA PMC5520901__F8 UCNPs-Ce6-mediated PDT and the mechanism of autophagy.Notes: UCNPs-Ce6-mediated PDT exhibits an autophagic response through the PI3K/Akt/mTOR signaling pathway that is regulated by ROS, which causes the ABCA1-dependent cholesterol efflux MTOR ABCA1 PMC3603396__F3 Altered colonic metabolites during conventionalisation TH RAN FARS2 GAL CAD SELE HAL ASNS PGAP1 GDA PMC6678174__F1 Mitophagy pathways ARIH1 PINK1 BNIP3 FUNDC1 OPTN PMC2929604__F1 Role of TLR4 in hepatic I/R injury HMGB1 TLR4 MAL IRF1 IRF3 CXCL10 MYD88 PMC9704080__F8 13-Acetoxysarcocrassolide induces apoptosis in human hepatocellular carcinoma cells through mitochondrial dysfunction and suppression of the PI3K/AKT/mTOR/p70S6K signalling pathway BAX BAD MTOR PMC3064322__F5 Model showing the regulation of PPARA by metabolism and PAR bZip transcription factors LPL NR1C1 FASN PMC8825381__F1 Progression and metastasis of small cell lung carcinoma: the role of the PI3K/Akt/mTOR pathway and metabolic alterations ACLY ASS1 ASL GLS HEL-S-133P PC LDHB PTEN MYC PMC5482641__F3 Collagen type IV alpha 1 (COL4A1) and collagen type XIII alpha 1 (COL13A1) produced in cancer cells promote tumor budding at the invasion front in human urothelial carcinoma of the bladder ST14 SMAD1 DKFZp781O1323 CFD KYNU HEL57 IFITM1 STEAP1 CTSS IRF7 CEBPA COL18A1 HPGD CGB3 UNG COL4A1 PRSS2 GJB3 DNASE2 CP PMC2790273__F1 Possible cross-talk between Nod2, TCR, Cd28, TLR and TNFR family members in regulating NFKB MAP3K7IP1 TAB3 RELA RELB NOD2 TRAF3 TRAF6 TRAF2 MYD88 PMC12068849__F1 Canonical and non-canonical signaling pathways CDC42 APC GSK3B LRP5 LRP6 ARHA NLK RAC1 CTNNB1 PMC12068849__F2 Wnt/Beta-catenin pathway activation and inhibition APC LRP5 LRP6 CTNNB1 ADA PMC12068849__F3 Wnt signaling within the breast cancer TME CD81 ABCD2 NRP1 NUMB RYK HIF1A DVL2 TCF4 VEGFA RUNX2 CCL2 CTNNB1 DKK3 BCL9 DKK1 FOXP3 CD163 CD68 SOX4 PMC5437112__F1 Illustration of autocrine and paracrine signaling pathways in colorectal cancer TNKS2 RBP2 APC BRAF SHH LRP6 EZH2 SMO KRAS AXIN2 CTNNB1 PMC10777970__F7 Hedgehog (Hh) signaling pathway SUFU PTCH1 SMO PMC4747347__F2 Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purpose ATG10 ATG3 PINK1 ATG12 ULK1 MTOR ATG5 ULK2 PMC5932548__F4 miRNAs in renal fibrosis SMAD4 PMC5932548__F3 Signalling pathways initiated by miRNAs and TGFB in diabetic nephropathy COL1A2 PAK1 PTEN PMC2254980__F3 Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice LPA TG FAS CPT2 ELOVL6 PMC2254980__F4 Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice TG FAS ELOVL6 PMC6442448__F2 Target-pathway network PPARG GRIA2 EGFR GSK3B NR1C2 HTR2A MTOR CCNA2 CCL2 NCF1 IFNG INSR ADRA2A PDE3A PTGS1 MMP3 KDR NOS2 PTGER3 IL10 SELE CD40LG PTGS2 MMP9 VEGFA TNF NR1C1 CHRM2 RELA RXRA ADRB2 CASP3 PMC10037992__F4 Fasting: From Physiology to Pathology PDX1 NEUROD1 MTOR PAX7 PMC6442448__F1 Compound-target network GRIA2 EGFR GSK3B F7 NR1C2 HTR2A CCNA2 CCL2 MPO IFNG PLAT INSR ADRA2A F10 F3 PDE3A DPP4 PRKCA THBD MMP2 MMP3 ABCG2 CRP NOS2 PTGER3 IL10 SELE IL4 CD40LG PTGS2 MMP9 VEGFA IL6 TNF SCN5A NR1C1 CHRM2 RELA RXRA ADRB2 BCL2 PTGES PMC8993538__F12 Optophysiology: Illuminating cell physiology with optogenetics STAT3 BAX EGFR CRY2 YAP1 PMC1450137__F4 Proposed mechanisms underlying the control of Mesp2 expression MESP2 TBX6 RBPJ PMC12027300__F2 Influenza viral suppression of the host immune response by upregulating cellular proteins SOCS1 IFNLR1 MAVS STAT2 EGFR IRF3 IRF7 SOCS3 HDAC1 STAT1 RUNX1 HLA-E ERAP1 SPHK2 HLA-G IFNAR2 IFNAR1 TET3 HLA-B JAK1 HLA-C TYK2 PMC12027300__F4 Upregulation of cellular proteins that control influenza viral pathogenicity SP1 OSM WNK4 TLR4 CTHRC1 CXCR4 MYD88 PMC5369369__F55 Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/Beta-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease KEAP1 APC LRP5 LRP6 IMPACT CTNNB1 PMC8387187__F8 Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis STAT3 CD14 SOCS3 PMC3167888__F6 Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages BAX BCL2 ATM APAF1 PMC8509806__F6 Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights BAX PTEN CDK4 PMC5085687__F5 Molecular mechanisms of osteoporosis in ACTH-secreting pituitary adenomas JUN ANGPT1 CRH HTRA1 NFATC1 GRB2 UNK SPP1 PMC11943880__F2 Physiological effects of KYN pathway metabolites TBK1 CDX2 CGAS MUC2 AHR IRF3 STC2 PMC8139196__F2 Delineating the Role of Mitophagy Inducers for Alzheimer Disease Patients SIRT3 TBK1 NLRP3 ULK1 DISC1 SIRT1 PARP1 SIRT6 PMC2727567__F1 Unwelcome Complement MASP1 FH MASP2 HEL-S-62p C4A PMC7070965__F7 EDG and DC on FcERI-mediated signaling pathway in KU812F cells SYK LAT LYN PMC11943880__F1 Kynurenine pathway HEL-S-90n KYNU KMO HAAO AFMID PMC12068849__F4 Interaction between the Wnt signaling pathway and other pathways in the breast cancer TME FRS2 WNT3A SMAD2 APC GSK3B LRP5 SMAD4 LRP6 FOXF2 FGF5C MTOR WNT7B WNT2B SFRP1 CTNNB1 FOXF1 KIF7 SUFU SHH FGF20 SMO WNT4 GRB2 FGF18 PMC4175047__F9 Proposed mechanisms by which miR-34a regulates mesangial cell proliferation CDK6 CDK2 CCND1 CDK4 PMC6737211__F5 Activation of Ser/Gly synthesis from glucose, their efficient incorporation into purines, and reverse flux of the Ser–Gly one-carbon pathway underlie preference for glucose as substrate for purine synthesis in lung cancer tissues ex vivo GLDC MTHFD2 CD2 MTHFD1 PHGDH MTHFD1L SHMT1 MTHFD2L HEL-S-51e PMC5623591__F3 Central tolerance for B cells SYK CD79B CD79A RAF1 STIM1 BLNK PTEN CD19 MYC BTK INSR FOXO1 BCR PLCG2 HEL-S-11 GRB2 PMC4891409__F1 MiRs and their targets in signaling pathway of LSCC MAX STAT3 CASP9 HGF PLK2 IRF9 SMAD2 APC SMAD4 PTEN IGF1R PDK2 SKP2 GALNT7 RUNX3 TGFBR1 CTNNB1 HDAC1 STAT1 FOXM1 JAK1 SIRT1 CCND1 PMC8214167__F6 Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictors STAT3 TBK1 STAT2 IRAK1 IRF3 IFI16 IRF7 TNF IRAK4 PELI1 MYD88 STAT1 NLRP3 TLR3 IFNAR2 IFNAR1 TLR8 TLR7 ITPKC PMC8945019__F5 Immunosuppressive Signaling Pathways as Targeted Cancer Therapies SUFU PTCH1 SHH SMO GLI3 PMC4673190__F1 The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer BAX ATR ATM MDM2 PMC6981480__F1 ER-stress induced UPR signaling ATF4 EIF2A PMC3135180__F3 Convergent stem cell regulatory networks control expression of key stem cell genes SOX2 LEF1 PMC3234195__F1 Petroleum diesel, biodiesel, and ethanol LPA tmp_locus_29 PC PMC10745821__F9 Proposed model of the signaling pathway induced by the CSHE treatment ACOX1 FOXO1 FASN PMC8599200__F6 Normal and Premature Adrenarche POR AKR1C2 AKR1C1 AKR1C4 PMC8715300__F12 Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome MMP12 DSC3 DUOX1 CXCL10 PMC10578286__F1 Insulin signaling pathway schematic PTEN INS IRS1 PMC4872805__F2 Sirtuins as regulators of metabolism and healthspan UCP2 SIRT3 NR1C1 NDUFA9 NCOR1 FOXO1 CRTC2 NRF1 SIRT1 PMC4872805__F3 Sirtuins as regulators of metabolism and healthspan UCP2 SIRT3 NR2A1 FOXO1 SIRT4 CRTC2 HIF1A SIRT2 SIRT1 SIRT6 PMC11395051__F7 The results and the proposed mechanisms of action of the examined proteins and signaling pathways in HEC-1A cells SOX17 STAT3 EGF TIMP1 CX3CR1 EGFR LIF BMP2 MMP2 IL6 MMP9 PMC4872805__F1 Sirtuins as regulators of metabolism and healthspan CDC2 NR1C1 HIC1 NCOR1 FOXO1 PARP2 SIRT1 PMC2739389__F2 Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape MAPK1 HGF BRAF PTEN IGF1R MTOR IGF2 MAPK3 CDK6 IGF1 FOXO1 CCND1 CDK4 PMC4765871__F8 Refined subnetwork using reconstructed pseudo time-series data (left) compared with experimental validated network in () (right) GATA2 NFE2 GFI1B GFI1 PMC3632131__F1 Shared network structure by non-small lung cancer pathway in KEGG and reconstructed co-expression networks using the CCA and GLASSO methods EGF BAD TGFA PIK3R5 SOS1 RASSF1 PIK3R3 AKT3 PIK3R1 PRKCB RB1 PLCG2 E2F3 PRKCA NRAS CCND1 CASP9 E2F2 KRAS ARAF HRAS FOXO3A SOS2 MAP2K2 GRB2 PMC3323563__F8 Activation of Cell Cycle Arrest and Apoptosis by the Proto-Oncogene Pim-2 CDK2 APAF1 PMC7279704__F1 Simplified representation of mechanisms of DDR and DNA repair OGG1 XRCC5 ATR RAD51 IGF1 BRCA1 BRCA2 TERT PALB2 SSB CPD XPC PMC3438135__F1 Altered pancreatic beta cell mechanism silencing alpha and delta cells TH MAPDA PI3 CRH HEL-S-11 PMC6416708__F1 Triglyceride-rich lipoprotein metabolism and mechanism of atherosclerosis LPL ANGPTL4 ANGPTL3 LDLR PMC2739389__F3 Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape BAX CASP9 BAD FAS CASP8 CAD CASP3 BCL2 APAF1 FADD PMC9169370__F2 Pyroptosis in inflammatory diseases and cancer CASP8 GSDMC GZMA GSDMB AIM2 DFNA5 TNF NLRC4 RIPK3 NLRP1 GSDMD CASP6 ZBP1 NLRP3 RIPK1 FADD PMC10987323__F7 MtETC in regulating bacterial infection IL10 NLRP3 HEL-S-62p C2 PMC8116547__F1 miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection LTB LTA COX1 LCK PMC6749033__F2 Metabolic regulation of pleotropic autophagy NNMT ULK1 NPRL2 LCMT1 PMC10987323__F9 MtETC in M1 macrophage polarization ACLY CIC RET PMC7204879__F4 HCoV-host interaction BAX BCL2 ATF4 PLP2 EIF2A PMC10151377__F3 Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases ADM CTNNB1 PMC7654518__F3 Molecular mechanisms of SGLT2 inhibitors on iron homeostasis, mitochondrial function, and cardiac microvasculature in diabetic cardiomyopathy TFAM FIS1 MFN1 MFN2 PMC9467784__F2 Targeting Strategies for Aberrant Lipid Metabolism Reprogramming and the Immune Microenvironment in Esophageal Cancer: A Review ACSS2 STAT3 HEL-S-62p TLR4 EGFR APC FASN EP300 MTOR PMC5706744__F1 Mammalian biogenic polyamines and metabolic pathways SMS OAZ1 SRM EIF5A PAOX SMO DOHH DHPS PMC4307161__F16 The Therapeutic Potential of Cystathionine Beta-Synthetase/Hydrogen Sulfide Inhibition in Cancer GOT2 PMC3250173__F7 TLR3/TLR4-mediated signaling pathways TIRAP TLR3 TLR4 MAL IRF3 MYD88 PMC6844216__F1 Different death mechanisms of liver cells are involved in the pathogenesis of liver injury induced by MNPs GSDMD TRADD MTOR PMC12207208__F3 TREM2 activation and downstream signaling TREM2 binds to ligands such as AB, ApoE, HDL, and LDL, leading to its activation TREM2 SYK TYROBP PMC6510993__F8 Model of GQ folding within the actively extending telomerase complex TERT POT1 TPP1 PMC5595712__F3 A maize amino acids network involving key genes identified in this study by GWAS NNAT IVD GAL PMC5559637__F5 H. pylori cag-T4SS-dependent, NFKB-driven innate immune response in gastric epithelial cells TIFA NOD1 TRAF6 ALPK1 PMC6480367__F1 Rapamycin (mTOR) signaling pathway RHEB TSC2 TSC1 TTI1 PTEN GRB2 DEPTOR PMC2561962__F1 Ischemia induces cell death by several distinct pathways, and Hsp70 reduces all of these BAX CASP9 FAS APAF1 PMC2775177__F1 Branches of the UPR signalling pathway ATF4 EIF2A XBP1 PMC11012680__F2 Synthetic Routes and Clinical Application of Representative Small-Molecule EGFR Inhibitors for Cancer Therapy EGFR GRB2 SRC PMC5301276__F2 Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases INPP4B AKT3 PTEN PMC8906189__F4 The Coagulation Pathways Leading to the Formation of D-Dimer During Blood-Brain Barrier Disruption APC PLG FDPS PMC10838060__F10 CGAS-STING by metal ions CGAS NLRP3 FEN1 STIM1 PMC7838386__F3 Extracellular factors govern dendritic morphogenesis via convergent signaling RHEB TSC2 TSC1 SMAD2 LECT2 PMC8883286__F3 Mechanisms Underlying Influence of Bioelectricity in Development CDC2 CDK6 CDK2 CDK4 PMC5420432__F1 mTOR signaling pathway in podocyte autophagy PKD1 TSC1 MTOR PMC8600424__F1 New insights into Epstein-Barr virus-associated tumors: Exosomes TSG101 CD63 TRAF2 PMC7827772__F3 Calreticulin (CRT) exposure in the response to immunogenic cell death (ICD) inducers SNAP23 BAX PMC11397228__F4 Impact of BPs on metabolic disease treatment via gut microbiota modulation FGF8A TG PYY TLR4 FASN MYD88 PMC5527946__F1 Regulation of autophagy RHEB TSC2 TSC1 UVRAG BCL2 GRB2 KRAS PMC1854955__F7 Schematic depiction of the molecular mechanism for the progression from HPS to chronic active disease or T-cell lymphoma in EBV-infected T cells TRADD TRAF5 TRAF2 FADD PMC5310163__F7 Interaction of lactobacilli with transformed cells LPO MPO PMC6306440__F1 Abnormalities in the DNA damage repair pathway in T cells of rheumatoid arthritis patients ATR MRE11A ATM PMC7442613__F1 Topical treatment strategies to manipulate human skin pigmentation MC1R POMC DCT TYRP1 PMC5932357__F2 Antimicrobial autophagy is inhibited in Mycobacterium leprae infections through the activation of the type I interferon (IFN) pathway TBK1 ESX1 CGAS OASL IRF3 PMC8995529__F5 Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway PCNA CYC1 MTOR RB1 CDKN2A CDK6 CDKN1A CDKN1B CASP3 CDK2 BIRC2 CCND1 CDK4 BIRC3 PMC6966636__F9 HMGCS2-mediated ketogenesis impacts liver cancer progression and treatment CDH2 BAX CCND1 PMC8995529__F1 Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway CYP1A2 PCNA CYP1A1 RB1 CDKN2A CDK6 CDKN1A CYP2C19 CDKN1B CASP3 CYP2C9 CDK2 BIRC2 CCND1 CDK4 BIRC3 PMC7179138__F5 Schematic diagram illustrating the mechanisms of A BAX BAD TRADD FADD PMC4393010__F12 Pathway regulation by CsrA HEL107 RPE HEL-S-162eP MAL GIP CS CIT PMC7998903__F5 Involvements of the studied neurotransmitters in tumor development EGR1 DRD2 ADRA1D MTOR RAP1GAP2 PMC3205804__F2 From a physiological point of view, exfoliated epithelial cells resulting from nutritional induction or mild stress are in anoikis by activating a survival mechanism partly using the molecular paths of macroautophagy RHEB MTOR IMPACT IRS1 PMC6966539__F2 p53 control of cellular metabolism F2 TIGAR SCO2 PDK2 PMC4014913__F2 Metabolic pathways of fatty acid (FA) and triacylglycerol (TAG) synthesis, and mechanisms by which lipid intermediates affect hepatic insulin sensitivity LPA FAS MTOR ELOVL6 IRS1 PMC6966539__F3 Dual effect of p53 on autophagy PINK1 ULK1 MTOR PMC10604560__F3 Lipid metabolism ACLY LPA TG NR1C1 CD36 FASN ELOVL6 TNF PMC4726449__F5 Identification of Symptomatic Fetuses Infected with Cytomegalovirus Using Amniotic Fluid Peptide Biomarkers CA3 TSC2 MAL HBD SCRIB MCM6 HEL-S-11 B2M PMC8868324__F7 Protective Effect of GIP against Monosodium Glutamate-Induced Ferroptosis in Mouse Hippocampal HT-22 Cells through the MAPK Signaling Pathway GPX4 GIP PMC5440785__F2 Schematic representation of the contribution of ER stress to the development of atherosclerosis
protein 1 ATF4 EIF2A XBP1 PMC6589170__F1 NLRP3 inflammasome pathway NLRP3 IL16 TLR4 MYD88 PMC8035014__F8 Immune regulatory activity of TCM formula ZQT in TME IFNG STAT3 GMDS PMC4026543__F2 EPH receptors crosstalk with EMT-related signaling pathways EPHB4 EPHB3 EPHA2 RAC1 CTNNB1 PMC8684645__F2 NK cell upraise in the dark world of cancer stem cells IL15 IFNG KLRG1 TNF CD34 PMC6126141__F1 Schwann cell Myc-interacting zinc-finger protein 1 without pox virus and zinc finger: epigenetic implications in a peripheral neuropathy KDM6B RBP2 GDNF KDM3A SHH ME1 SOX10 EGR2 HDAC2 JMJD5 KDM4C PMC9034918__F6 Screening Potential Drugs for the Development of NAFLD Based on Drug Perturbation Gene Set APP PMC7862630__F3 Deubiquitylases in developmental ubiquitin signaling and congenital diseases USP44 MYSM1 BAP1 SMAD4 USP9X USP15 USP4 USP1 USP22 OTUD5 USP21 USP26 USP16 PMC9550461__F4 Endogenous Vasoactive Peptides and Vascular Aging-Related Diseases STAT3 RAMP1 EGFR SRC NOX4 PMC5285405__F3 Viruses exploit host proteasome pathway for immune evasion RAD50 MRE11A SP100 MAL RELA PML IFI16 IRF3 IRF7 MYD88 PMC8324245__F7 Ovine CD14- an Immune Response Gene Has a Role Against Gastrointestinal Nematode Haemonchus contortus—A Novel Report CD40 TIRAP CTSK TLR9 CD14 TLR5 IRF3 IRF7 TRAF3 TNF TRAF6 MYD88 TLR3 LBP FADD PMC5285405__F5 Viral regulation of host proteins via post translational modifications HDAC3 IFRD1 EGFR RELA PML IRF3 PMC9256444__F6 Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting SMAD2 SMAD4 PTEN MTOR PMC9256444__F5 Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting APC GSK3B LRP5 LRP6 SMO CTNNB1 PMC8469761__F1 Glycosylation in Vascular Calcification SMAD1 DKFZp781O1323 BMP2 MTOR RUNX2 CTNNB1 FGF23 PMC9256444__F2 Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting CXCL12 TNC HGF TGFA MSC MMP2 MMP3 MMP9 VEGFA PMC12166595__F2 The Notch signalling pathway and conservation of its components across metazoan lineages HDAC1 NEDD4 ATXN1L NUMB ADAM10 FURIN PMC8511326__F4 Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch PPP1R3A KRT1 TMOD1 PHKA1 HEL-S-273 DMP1 ADRA1A TRAIP NTSR1 CHRM3 ASB10 TRIM63 RPTN TPM1 TGM1 CASP14 HRC tmp_locus_29 PHKB GGH CSTA ASB14 FGF23 ASB18 ASB16 CERS3 PYGM NIPAL4 CXCR6 FBXO40 TNNT3 FGF22 NTSR2 ASB4 XCL1 CXCL2 LIPN FGF5C UBE2D1 UTS2R IGFBP5 CRISP3 NOTUM MMP27 EDNRB IL8RB ZBTB16 ASB2 PMC6561926__F9 Schematic depiction of lncRNA-p21/EZH2/STAT3 pathway STAT3 PMC8801635__F12 Protective effect of baicalin against arsenic trioxide-induced acute hepatic injury in mice through JAK2/STAT3 signaling pathway ALB STAT3 BAX PMC2697619__F5 Proposed signaling pathways by which the Tec kinases regulate JNK activation, actin polymerization, and cytokine expression in LPS-stimulated neutrophils CDC42 TEC SYK TLR4 CD14 LBP IL1B PMC6982012__F2 Conversion into myofibroblasts from quiescent fibroblast involves mechanical and paracrine activation of profibrotic pathways SMAD2 SMAD4 PMC3342643__F3 Diacylglycerol kinases in immune cell function and self-tolerance PLCG1 BCL10 PMC6337644__F3 Telomeres are cap-like features at the ends of chromosomes that help protect them when cells divide AACS CS PMC7472989__F1 Classical neuroimmune network IFNG GC IL1B PMC8764250__F3 Interleukin 27 Signaling in Rheumatoid Arthritis Patients: Good or Evil? STAT1 JAK1 TYK2 GATA3 PMC7653026__F3 NFKB inflammation signaling pathway diagram TLR1 TLR4 TLR5 TRAF6 MYD88 PMC9359100__F7 Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication NLRP3 MFN2 IRF7 PMC7246618__F1 Monoubiquitination in human diseases FANCD2 CBL ITCH PCNA EGFR USP1 HLTF UBE2A FANCL PMC11241178__F8 Target pathway analysis of cordycepin combined with doxorubicin against breast cancer CASP8 TRADD ITCH JUNB NFKB1 CXCL1 CASP3 MMP3 MAP3K7 MMP9 CCL2 TNF PMC8584933__F1 Genome-Wide Analysis of Alternative Splicing and Non-Coding RNAs Reveal Complicated Transcriptional Regulation in Cannabis sativa L. IPP LOX PMC2937452__F1 Model of pyrimidine synthesis and salvage pathways in Toxoplasma gondii UPRT OMP DHODH PMC10761042__F8 PTP1B-Cdk3 Signaling Axis Promotes Cell Cycle Progression of Human Glioblastoma Cells through an Rb-E2F Dependent Pathway CDC2 CCNE1 CDK3 PMC10506040__F2 Schematic representation showing downstream signaling events in cross-talk between adiponectin signal transduction and insulin signaling pathway[67] APPL1 ADIPOR1 ADIPOR2 PTEN IRS1 PMC12091695__F1 Simplified schematic representation of steps linking dyslipidemia with macrophage/microglia induced RNV TREM1 ACAT1 HEL-S-5 LDLR IL6 TNF PMC6953124__F9 Proposed anti-tumor mechanism of rubioncolin C MAP3K7IP1 MTOR TRAF6 TRAF2 MYD88 PMC5677515__F3 Significantly Mutated Genes and Regulatory Pathways in SCLC – A Meta-analysis ROBO3 BOC HEL-S-28 RYK ROBO1 ARHA ROBO2 NEK1 FYN RAD1 RHOD PTCH1 SHH FES RRAS SMO SIT1 SEMA7A PMC8802069__F9 Activation of Autophagy Through the NLRP3/mTOR Pathway: A Potential Mechanism for Alleviation of Pneumonia by QingFei Yin SPN NLRP3 MTOR PMC3725781__F1 Genetic and molecular control of Osterix in skeletal formation COL1A1 SOX9 IGF1 BMP2 RUNX2 XBP1 PMC3642687__F1 Pathway of reversible protein modification reactions that involve NAD+ consumption MACROD2 PARG MACROD1 PMC3437319__F2 Regulation of mammalian target of rapamycin complex (mTORC) signaling networks RHEB TSC2 TSC1 IRS1 EIF4E PMC5618627__F3 HSP40 family member, DNAJB6a (MRJ), prevents tumor formation through inhibition of the Wnt pathway DNAJB6 WNT3A MSX1 DKK1 APC GSK3B LRP5 WNT1 LRP6 CTNNB1 PMC5618627__F2 HSP27 mediated suppression of apoptosis promotes tumorigenesis FAS MAPKAPK2 MAPKAPK3 PMC7403357__F3 Bioinformatics analysis of data MDK SYK OLFM4 FERMT3 FAS RGCC PML CR2 IL18BP PRKCB NELL1 SP100 PIM3 F10 APLN ADAM12 SRGN MYL7 CSF2 SELL ECT2 LGALS9B KIT ITGB3 HS6ST2 CXCL10 S1PR5 RNF213 SEMA4D ITGAM IGF1 PROK2 AIF1 ZBTB16 TWIST1 NDP PMC7987459__F2 Molecular pathways affected by Mn porphyrins in normal and cancer cell HEL-S-22 UCP3 HEL-S-21 KEAP1 GCLM SMAD2 PRX SMAD4 CTSS NOX4 MAPK14 EIF5B GRB2 ATG5 PMC7881125__F6 Distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma AMD1 SRM CTH EZH2 MTR HEL-S-51e PMC9576726__F7 Effects of MSC-Exos on glycolysis and renal fibrosis TEC MSC PFKM PMC11222861__F8 Brief proposal model of altered epigenetic regulation mechanisms of histone H3K27 acetylation causing FLHS and a summarized workflow of comparative analysis of fatty liver disease among different species APOA4 INHBE MAMDC2 NTRK2 KIT PCK1 PMC4150259__F1 An overview of oncogenic KRAS-driven RAF/MEK/ERK and PI3K/PDK1/AKT signalling networks in pancreatic cancer EGF EGFR PTEN MTOR KRAS PMC4402634__F3 KEGG pathway map for TGFB and MAPK signaling pathways MAX FRK SKP1 NODAL UST DAO PMC7501485__F7 Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways BAX BCL2 ATF4 PMC4402634__F4 KEGG pathway map for complement and coagulation pathway C6 SERPINF2 CPB2 KLKB1 HEL-S-62p F7 CR2 CS PLAT F2R F2 F10 F3 PROS1 C9 THBD A2M F8 F9 PROC VWF C7 PLAUR PLG F11 TFPI C2 PMC6838686__F2 Systemic Immune Dyshomeostasis Model and Pathways in Alzheimer’s Disease NGF PEMT APOE CCR2 GSK3B IL18 PC ChAT IL6 BDNF PMC9078761__F7 Network Pharmacology and Molecular Docking-Based Strategy to Investigate the Multitarget Mechanisms of Shenqi Yizhi Granule on Alzheimer's Disease HTRA2 ATXN3 BAX CASP9 CASP8 LRRK2 BACE1 PDYN SNCA ATXN2 VCP VAPB TRPC3 PMC8064375__F4 Persulfidated proteins identified in root tissues involved in autophagy ATG10 ATG3 ATG12 PMC3646067__F1 Proposed scheme linking metabolic and signaling pathways to insulin resistance in the heart TRO TG CD36 HEL-S-5 MTOR IRS1 PMC3512574__F5 TGFB in Cancer ATF3 SMAD1 E2F4 SMAD4 CDK2 MYC ID1 CDK4 FOXG1 PMC6360516__F7 LIMK2-Mediated Cofilin1 Phosphorylation Signals TGFB1-Induced GC InsensitivityPhospho-cofilin1 is implicated as a key link in the chain of signalling behavior of TGFB1-induced GC insensitivity CDC42 LPA LIMK2 PMC12248293__F9 BRD4770 attenuating DOX-induced cardiac injury through the Nrf2/ATF4/SLC7A11 pathway GPX4 SLC7A11 ATF4 PMC6549480__F7 A schematic molecular model for PSMD3 in the stabilization of HER2 USP14 PSMD3 PMC5594516__F9 Schematic representation of the proposed mechanism of circLARP4 in GC cells LATS1 AGO2 GC LARP4 PMC3512574__F3 TGFB in Cancer CDC42 TGFBI LIMK1 NODAL RHO TRAF6 GDF6 GDF5 gdf7 ACTR2 LEFTY1 CRIPTO BMP4 BMP2 LEFTY2 AMHR2 PMC8258161__F1 Robustifying Experimental Tracer Design for13C-Metabolic Flux Analysis EMP1 GAL WIZ MAL DAP PMC6134143__F5 TNFR2-triggered, necrostatin-1-sensitive TNFR1 signaling RIPK3 CASP8 MLKL RIPK1 TRAF1 TNF TRAF2 IL1B PMC5233421__F6 Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability SERPINE2 VCAM1 PECAM1 PMC1665458__F7 Proteins differentially regulated in RCC involved in carbohydrate metabolism are shown overlaid on the glycolysis and gluconeogenesis pathway KEGG #00010 diagram PCK2 ECHS1 SUCLG1 ENO2 HEL-S-133P HEL-S-87p HEL-S-165mP PMC11173325__F1 The mTOR signaling pathway and the cellular functions driven by the formation of its two main complexes, mTORC1 and mTORC2 RHEB TSC2 TSC1 SGK1 TTI1 PTEN DEPTOR IRS1 PMC11173325__F2 Roles of mTORC1 and mTORC2 in regulating metabolic diseases, cancer, and aging TG NLRC3 PTEN FURIN IRS1 EIF4E PMC7082927__F1 Molecular pathogenesis of thyroid cancer involves dysregulation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K)/AKT pathways PPARG PAX8 BRAF TERT PTEN CTNNB1 PMC8097461__F6 Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin IPP MAL EIF5A FOS CIT PMC7082274__F1 Steroidogenic pathway for aldosterone and the ‘hybrid steroids’—18OH-cortisol and 18-oxocortisol HSD3B2 CYP21A2 STAR CYP17A1 CYP11B2 CYP11A1 PMC4629494__F1 Pyruvate and octanoate metabolism in the liver PC CS CIT PMC7017171__F1 Phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway MTOR PCK1 PMC4023029__F7 Proposed pathway for activation/proliferation of alloantigen-specific nTreg and comparison with the non-antigen driven proliferation of nTreg that do not have a TCR specific for the antigen IL5RA FOXP3 PMC4775314__F3 Untapped Potential of Tyrosine-based G Protein Signaling STAT3 TLR4 SI PMC8443980__F1 Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases PINK1 NLRP3 ATG12 UCP1 ATG5 PMC8122529__F2 Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process RBX1 KEAP1 GCLM PMC8122529__F3 Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process RBX1 KEAP1 GCLM PMC3319771__F2 Convergence of miR-21 target genes and the apoptosis pathway BAX MSH6 BAD FAS MSH2 TRADD PTEN DAP3 TNF PELI1 TGFBR2 SPRY2 NR1C1 TP63 APAF1 SPRY1 FADD PMC7797171__F5 Reversine, a selective MPS1 inhibitor, induced autophagic cell death via diminished glucose uptake and ATP production in cholangiocarcinoma cells SP1 CCNB1 SRC PMC6323245__F1 Different stages of erythropoiesis and regulatory processes (including cytokines, transcription factors and related signal transduction proteins) GATA2 NFE2 GFI1B tal-1 GATA1 IGF1 EPOR EPO IGF1R LYN PMC6323245__F2 PI3K/Akt signaling pathway and glucose metabolism (glycolysis, glucose uptake, nitric oxide glucose synthase, apoptosis and cell survival) EGF BAD EGFR PTEN PDK2 MTOR PMC4593336__F1 Canonical Wnt3a pathway CD44 FOXM1 WNT3A APC ROR2 MARCKS LRP5 LRP6 SULF2 CTNNB1 PMC7173926__F5 Computational analysis for identification of the extracellular matrix molecules involved in endometrial cancer progression CRP ARHG LAT COL28A1 COL26A1 COL10A1 COL23A1 ITGB3 COL19A1 COL13A1 ITGA2B COL24A1 COL2A1 COL25A1 BTK FYN COL22A1 PLCG2 SCHIP1 COL27A1 COL4A1 COL12A1 ADAM10 LYN PMC3991963__F1 TGFB2 and Bone Morphogenetic Proteins in the Trabecular Meshwork and Glaucoma LTBP1 SMAD1 THBS1 LOXL2 BMP1 LOX DKFZp781O1323 LOXL3 LOXL4 FST BMP4 PMC7137995__F5 Elucidation of Functional Roles of Sialic Acids in Cancer Migration GAL GM2A B4GALNT1 ST8SIA5 NEU1 ST3GAL5 ST8SIA1 B3GALT4 GLB1 ST3GAL1 PMC4898408__F3 Hub-pathway network of GSZD PPARG JUN LTA CHUK FLG PROC TNF FCGR2A PARP1 NR3C1 PMC3572738__F4 Cellular iron balance FBXL5 SKP1 ALAS2 PMC8120506__F2 Mitochondrial biogenesis signaling pathway is a potential therapeutic target for myasthenia gravis via energy metabolism (Review) TFAM NRF1 SIRT1 PMC9588203__F1 Triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases ZAP70 SYK COX2 HEL-S-11 PMC8198060__F2 Ubiquitin Proteasome Pathway Transcriptome in Epithelial Ovarian Cancer FANCD2 BRCA1 USP1 FANCL FANCA SLX4 UBE2T FANCC FANCB PMC5629289__F2 IFNA2: The prototypic human alpha interferon STAT1 STAT2 IRF9 JAK1 TYK2 PMC7426442__F3 SARS-CoV-mediated evasion of host innate immune response STAT2 IRF3 ACE2 PMC6149701__F1 Dual Regulation of NFKB signaling by SIRT6 SUV39H1 SKP2 SIRT6 PMC6161481__F8 The proposed pathways activated by LPS to modulate mTOR-dependent autophagy and the production of pro-inflammatory cytokines in Caco-2 and HT-29 cells MAP3K7IP1 TLR4 MTOR IL1B MYD88 PMC8489073__F6 Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges AURKA SOS1 EGFR PTEN IGF1R MTOR KRAS IRS1 HRAS SNAI1 NF1 RIT1 NRAS RET PMC3341105__F2 Signal transducer and activator of transcription 3 (Stat3) signaling CD44 MTOR SRC PMC7947625__F1 Mevalonate (MVA) pathway and its connection with the intracellular energy metabolism signaling IPP HEL-S-26 PMC9367564__F1 Versatile Triad Alliance: Bile Acid, Taurine and Microbiota PYY CYP8B1 CYP7A1 FGFR4 PMC8683177__F1 Tumor-Specificity Growth Factor Combined with Tumor Markers in Nuclear Medicine Imaging to Identify Prostate Cancer Osteonosus BAX SYK CD2 BAD LTA CBL GRB2 TRAF6 MYD88 PMC3507315__F2 T cell receptor signaling pathway extracted from BioCarta database ZAP70 JUN FYN PLAT LAT GRB2 PMC3507315__F3 Fc epsilon receptor I signaling in mast cell pathway extracted from BioCarta database SYK BTK LYN GRB2 PMC3507315__F9 mTOR signaling pathway extracted from KEGG database RHEB TSC2 RICTOR BRAF MTOR EIF4E PMC7317062__F1 Neurofibromin is a negative RAS regulator LATS1 LATS2 NF1 EGFR NF2 MTOR JAK1 TYK2 PMC2981516__F6 Demosponge EST Sequencing Reveals a Complex Genetic Toolkit of the Simplest Metazoans ELL PMC9469581__F5 TRIM proteins in hepatocellular carcinoma TRIM31 BAX TRIM7 TRIM32 SMAD2 PML SMAD4 PTEN ARC TRIM59 TRIM44 TSC2 TRIM28 TRIM24 TRIM25 TRIM37 TRIM52 TRIM71 TRIM66 SRC TRIM65 PMC4924289__F1 Summary of the signalling pathways known to control the switch between dauer and growth in C NCR1 NCR2 IGF1 PPM2C INS PMC2948292__F1 Potential roles of BLM and RECQ5 in sister chromatid exchange regulation RAD51 F3 BLM PMC5008074__F3 MicroRNA (miRNA) biogenesis pathway and its regulation by Smad proteins TF RAN DGCR8 DROSHA PMC6390811__F1 GPCR/Beta-arr-dependent signal pathways controlling cell survival, cytoskeleton remodeling, and gene expression, leading to enhanced cell growth, invasion and metastasis RALA HEL-S-28 TCF4 ARHA MTOR SRC CTNNB1 PMC3834580__F2 Future of targeted agents in metastatic colorectal cancer EGFR GRB2 MTOR PMC2013735__F4 GenMapp pathway showing the impact of 1 week of STZ-DM on transcription in pathways related to cytokines and the inflammatory response GEM GNAT2 WAS PMC6863766__F5 Metabolomics study of fasudil on cisplatin-induced kidney injury FAS ACD PMC4856801__F1 Proposed model depicting the opposing roles of type I and type II NKT cells in inflammatory diseases in the liver IFNG FAS CCR6 HEL-S-70p PMC6470438__F6 Activating p38 MAPK intersection signaling pathway CDC42 STAT1 MAPKAPK2 MAPKAPK3 RAC1 PMC4022190__F7 Biosynthetic pathway leading to the hypermodified tRNA base wybutosine (yW) TYW3 TYW1 PMC9099196__F4 Gut homeostasis, injury, and healing: New therapeutic targets ARHA GRB2 RAC1 PMC7970828__F6 Synthesis Pathway and Protein-Protein Interaction (PPI) Network of the Elevated IGPs Modified by HM Glycans in Tumor TNC PLOD1 HLA-DRA PRKCSH MAN1A1 HEL-S-130P GNS HEL-S-84 GGH PSAP CTSC PMC3056511__F7 Schematic summarizing the present findings NGF MTOR ELF3 EIF4E PMC5362350__F1 Role of Autophagy in HIV Pathogenesis and Drug Abuse ATG10 ATG12 ULK1 ATG14 MTOR ATG5 PMC4424331__F11 The molecular mechanism of iron-induced RPE C3 production involves ERK1/2, SMAD3, and C/EBPD signaling HEL-S-62p CEBPD PMC4943391__F2 Melanocyte differentiation pathway dependent on MSHA and ACTH MC2R TYRP1 CREB1 PMC3318211__F1 Signaling pathways involved in anthracycline-induced cardiomyocyte injury BAX BAD ERBB2 GATA4 PMC8696122__F8 Brain and Pituitary Transcriptome Analyses Reveal the Differential Regulation of Reproduction-Related LncRNAs and mRNAs in Cynoglossus semilaevis HBEGF LHB GNRHR EGFR MMP2 GRB2 FSHB PMC8890943__F13 Potential mechanism of MET alleviating COPD and CSE-induced GC resistance through activating Nrf2/HO-1 signaling pathway, which can promote the function and expression of MRP1 to increase the expression of HDAC2 KEAP1 GC GCGR HDAC2 PMC9109253__F1 Novel Small Molecule Approach for the Treatment of Propionic and Methylmalonic Acidemias. NAGS HEL-S-62p PMC4682803__F1 MTORC1 signaling to the translational machinery MLST8 EIF4B LARP1 DEPTOR PMC3962547__F14 Integration of metabolic control, cell growth and proliferation, and their regulation by phosphoinositides RHEB TSC2 PMC5755497__F7A Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation DVL1 FGF7A SALL4 APC SOX2 UTF1 NODAL ZIC3 PMC5845450__F1 Central metabolic pathways of Geobacillus LC300 based on the genome annotation TAC3 MAL CIT PMC6940594__F4 ILK Signalling pathway generated using IPA KRT18 HEL114 HEL113 PXN COX2 BMP2 MMP9 TNF NACA LEF1 PMC3888279__F3 Regulation of hypoxia-inducible factor (HIF)–A expression or stabilization by pathways other than hypoxia SUMO1 RBX1 EGFR IGF1R MDM2 RET PMC8824234__F2 Heterotopic Ossification: Clinical Features, Basic Researches, and Mechanical Stimulations SMAD1 SOST ACVR1 LRP5 LRP6 RUNX2 SIRT1 CTNNB1 RUNX3 PMC11841850__F1 Heme biosynthetic pathway and multisystemic manifestations in EPP and XLP CPOX ALAS2 FECH UROD UROS PMC3237908__F4 Schematic diagram shows the possible effect of xanthones on the apoptosis pathways BAX FADD PMC5462749__F8 Working model of Beta-Lap in acute pancreatitis HMGB1 NLRP3 SIRT1 PMC11173086__F9 Proposed regulatory network of bulbil initiation in P TF LOX SNRK RAX PMC5037829__F2 UPR mechanism BAX ELF2 ATF4 TRAF2 PMC5460122__F6 Lipotoxicity-induced NLRP3 inflammasome activation in TEC NLRP3 CD36 TLR4 LDLR SIRT1 IL1B PMC3342643__F5 Diacylglycerol kinases in immune cell function and self-tolerance GSK3B IRAK1 TRAF6 IRAK4 MYD88 PMC8961591__F1 Pathophysiology of H2S in Renal Glomerular Diseases DAO PMC5755497__F8A Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation VEGFB VEGFC VEGFD GRB2 VEGFA PMC3744053__F5 Signaling pathways of anti-permeability factors VEGFA SRC PMC6953027__F2 Signaling and gene regulatory networks in pluripotent (naїve and primed) and teratocarcinoma stem cells MAX KLF4 EGF KLF2 CD2 HGF ID2 LIF SMAD6 DUSP9 SOX2 NODAL PAX6 ID1 CTNNB1 ESRRB CDX2 TCF3 FOXD3 CRIPTO GSC BDNF CDK4 PMC6953027__F1 TGFB Family Signaling Pathways in Pluripotent and Teratocarcinoma Stem Cells’ Fate Decisions: Balancing Between Self-Renewal, Differentiation, and Cancer BMP10 EGF JUN TGFB1 HGF LIF SMAD6 NODAL TNF TRAF6 GDF6 CTNNB1 GDF3 BMP6 gdf7 CRIPTO BMP4 BMP2 GDF1 BDNF GDF9 PMC3070859__F1 Cohesin regulates expression of genes that control differentiation, morphogenesis, proliferation, and pluripotency STAG2 MYC NIPBL PMC6894227__F1 Metabolic pathway of DEGs related to lipid metabolism in the liver by DNA microarray analysis EHHADH ACSL1 AKR1D1 CYP7A1 FACL4 DHCR24 FABP4 CYP46A1 CYP7B1 FDFT1 PMC4969764__F3 STRING v10.0 protein–protein interaction network based on input of 164 proteins of interest ARVCF WNK1 RIMS1 CRMP1 ATP2B4 FAF2 TPR APBA1 ARFGAP3 CARM1 PRPF19 MRPL40 SYDE2 AIP PRNP PLCH2 UBXN2B MRPL38 PIP4K2B C14orf133 SEC11C HNRNPF SRSF10 GFOD1 TIAM1 PTBP1 DKFZp686P11128 PRRT2 SNW1 HNRNPUL1 APLP1 RPS9 PMC9369123__F4 PKC-MAPK Signalling Pathways in the Development of Hyperglycemia-Induced Cardiovascular Complications BAX VCAM1 PMC8490125__F3 Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases GSDMD NLRP3 COX2 TXNIP TLR4 IL1B MYD88 PMC11754893__F8 Mechanism diagram of MH regulating S100A8-CAMKK2-AMPK axis against cerebral IR injury BAX CAMKK2 S100A8 PMC12182054__F1 FGF19-FGFR4-KLB signaling pathway FGF8A FRS2 FGFR4 GRB2 CTNNB1 PMC9454615__F5 Impact of COVID-19 on populations living at high altitude: Role of hypoxia-inducible factors (HIFs) signaling pathway in SARS-CoV-2 infection and replication TMPRSS2 TRPA1 TLR3 IRF3 IRF7 TRAF3 TRAF6 MYD88 PMC2621116__F2 Representative plasmids used in this study ETFA HBD PMC11953998__F5 Schematic illustrations showing different nano-targeting systems achieving precise mitochondrial localization and killing tumor cells through mtDNA perturbation (a–b) and metabolism disruption (c–d) TFAM TBK1 CGAS IRF3 PMC7564652__F3 AD pathway with target genes of upregulated miRNAs highlighted BAGE LPL IDE CASP9 APC SNCA ACD TUBB INS AFP RTN4 ABO CASP3 FES APP APAF1 TRAF2 FADD PMC7564652__F4 AD pathway with target genes of downregulated miRNAs highlighted LPL IDE ATR BAD LEP APC SNCA MTOR IL6 TUBB TNF INS AFP INSR ABO APP TRAF2 FADD PMC9454615__F2 Impact of COVID-19 on populations living at high altitude: Role of hypoxia-inducible factors (HIFs) signaling pathway in SARS-CoV-2 infection and replication TRPA1 KEAP1 PMC9454615__F3 Impact of COVID-19 on populations living at high altitude: Role of hypoxia-inducible factors (HIFs) signaling pathway in SARS-CoV-2 infection and replication TMPRSS2 MGRA ACE2 PMC2868782__F3 Comparison of protein and gene expression studies POR SAFB MTOR PMC3668182__F2 Specification of GABAergic Cortical Interneurons LHX6 ARX SST LHX8 SOX6 DLX1 GSX1 GSX2 DLX6 SHH DLX2 NPY DLX5 PMC4521019__F2 Regulation of hepcidin expression by iron and inflammation STAT3 BMP6 SMAD1 TFR2 DKFZp781O1323 HFE JAK1 HFE2 PMC3833184__F3 Lineage-specific positive selection in the naked mole rat BRCA1/FANC pathway FANCE FANCD2 FANCG FANCF RAD51 BRCA1 BRCA2 FANCA FANCC PMC4931664__F1 Canonical NFKB pathway (left) induced by signals including antigens, TLR ligands and cytokines such as TNF uses a wide variety of signaling adaptors to engage and activate the IKKB subunit of the IKK complex CD40 BCR RELB PMC6331247__F2 Pathway for the relationship between MS4A6A SNPs, blood gene expression and Alzheimer’s disease phenotype MS4A6A AGA PMC7836472__F5 Network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer RAF1 EGFR ERBB2 IL6 MTOR MYC CCND1 PMC8537037__F2 Abscopal Effect: A Review of Pre-Clinical and Clinical Advances CD80 HMGB1 CGAS TLR4 CTLA4 PMC7664031__F7 Common altered signature as effect of multiple dose exposure to doxorubicine a Common altered up- and downregulated genes between P12 and P24 in Hs578T and MDA-MB-231 FHAD1 CYP21A2 RRAD EPHX1 ABCC3 MX1 TNFSF10 TNF PMC4732619__F7 FoxC2 Enhances BMP7-Mediated Anabolism in Nucleus Pulposus Cells of the Intervertebral Disc SMAD1 DKFZp781O1323 FOXC2 SMAD4 PMC3601410__F1 Nrf2 is bound to Keap1 in the cytoplasm KEAP1 NQO1 MAF PMC3601410__F2 Most of the studies on Nrf2 and obesity-metabolic syndrome have focused on liver and white adipose tissue FAS FGF21 RXRA AHR FABP4 NOTCH1 PMC7136349__F2 Targeting of the complement cascade in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis C6 C7 C9 PMC8516647__F4 Functions of the XAF-1 protein in promoting p53 mediated apoptosis SIAH2 HIPK2 MDM2 XAF1 PMC9699629__F3 Immunomodulatory Role of Thioredoxin Interacting Protein in Cancer’s Impediments: Current Understanding and Therapeutic Implications STAT3 TXNIP MLX MTOR KCNK3 PMC8619339__F3 Nanostring-Based Identification of the Gene Expression Profile in Trigger Finger Samples POR SOST INVS ROCK2 CBY1 RHOD APC WAS SKP1 RYK PC4 PMC9699629__F1 Immunomodulatory Role of Thioredoxin Interacting Protein in Cancer’s Impediments: Current Understanding and Therapeutic Implications TXNIP HAL WAC PMC3708286__F2 Signaling pathways that relate disturbed polycystin-mediated Ca2+signaling to cell proliferation TSC2 TSC1 SRC PMC7671657__F1 PI3K signaling pathway TSC2 TSC1 FOXO1 GYS1 EGFR PTEN PMC6482165__F1 Hypothalamic regulation of energy homeostasis in healthy (blue) and obesity (pink) STAT3 FOXO1 TLR4 POMC MC4R MC3R NPY ARC AgRP PMC6935452__F2 Canonical and noncanonical Notch signaling pathway HEY2 SI NPB CTNNB1 PMC11315658__F5 Synergism between TMEM16A and EGFR in mediating the proliferation of tumors STAT3 EGFR GRB2 CCND1 PMC2751999__F6 LPA effect and signal transduction pathway LPA MAPK14 STAT1 TSC2 TSC1 RAF1 GIP RHO MTOR MYC LPP PMC11083695__F1 Canonical hedgehog signaling pathway acts after the hedgehog (HH) ligands join the Patched-1 (PTCH-1) to release Smoothened (SMO) and enhance the translocation of glioma-associated oncogene (GLI) into the nucleus FOXF1 HOXD8 SUFU SMO PMC11083695__F2 Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma HEL164 SMO RHO MTOR CTNNB1 PMC4007467__F11 Proposed integrin signaling switch model FYN SRC PMC9137930__F4 Flavonoids-Based Delivery Systems towards Cancer Therapies BAX APAF1 PMC7058935__F11 Wnt5b integrates with Fak1a to mediate cell movements during gastrulation CDC42 WNT5B RYK SRC RAC1 DAAM1 PMC8500950__F1 Smoking‐aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome NLRP3 NQO1 IL1B PMC10627266__F5 CEBPB increases inflammation/SASP independent of DDR pathway to promote senescence ATR IL12A CXCL5 ATM CXCL2 IL6 CEBPB PMC2836783__F2 CD62L regulation by T-cell receptor (TCR) stimulation and Gc-cytokines IL15 ZAP70 KLF2 FYN ADAM17 FOXO1 CCR7 IL7R IL2 MTOR IL15RA LCK PMC3364461__F4 PI3K/mTOR signaling at the FSHR RHEB RPS6 TSC2 GSK3B PTEN MTOR FSHR PMC6611790__F5 Hypothesis of the mechanism of IDH mutant gliomas TET2 PC BBOX1 PMC9399632__F3 Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics BAX TRADD TRAF2 FADD PMC3364461__F1 Multiple transduction mechanisms induced at the FSHR RPS6 APPL1 EGFR FSHR CDK4 PMC3594038__F1 Btk activates antiapoptotic pathways BAD BTK MDM2 PMC5276719__F2 Interconnections Between Autophagy and Integrin-Mediated Cell Adhesion BAX EGFR AMBRA1 BMF SRC PMC12150590__F5 Timeline of clinical trials of drugs targeting Wnt/Beta-catenin signaling pathway PORCN DKK1 LRP5 PMC12150590__F3 Wnt/Beta-catenin signaling pathway in cancer development and drug resistance FAT4 RNF128 NINJ1 VASP C5AR1 GPX4 TUBB6 SEC62 CTNNB1 EPHB2 FOXM1 CDX2 CDK6 CDK12 PORCN HEL-S-29 SP4 USP6NL TM7SF2 TSPAN1 DDX5 HEL-S-302 APC LRP5 LRP6 EZH2 MIF KDM1A CAVIN1 SETD1A RUNX1 HEL-S-112 TM4SF1 PMC3403928__F4 Caspase cascade HEL-S-62p C8A TNF PMC12150590__F4 Therapeutic strategies of targeted drugs in Wnt/Beta-catenin signaling pathway PORCN APC LRP5 LRP6 CTNNB1 PMC12150590__F1 Mechanism of canonical Wnt pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC12150590__F2 Mechanism of non-canonical Wnt signaling pathways CDC42 JUN APC ARHA NLK CTNNB1 PMC6893874__F1 Diphthamide biosynthetic pathway DPH2 DPH6 DPH7 DPH5 PMC8663935__F4 Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions RHEB TSC1 ULK1 TFEB PTEN PMC8573099__F6 Branched-Chain Amino Acids Catabolism Pathway Regulation Plays a Critical Role in the Improvement of Leukopenia Induced by Cyclophosphamide in 4T1 Tumor-Bearing Mice Treated With Lvjiaobuxue Granule HK3 SLC27A2 MIOX DAO ASPA FARS2 LCT BCAT2 pcap SI PC TPO GAD2 PAH GCK PKLR GPT CHKB GAA HEL-S-133P HK2 CPA3 GPT2 LDHB SHE ME3 GANC EPX AASDHPPT LGALS13 HACL2 VARS2 CPA6 CLC DLD ChAT CHKA TH EHHADH GANAB MPO HADHB TTL IMPA2 BAAT FARSLA FARSB LDHD AGA ACHE CAD PLD2 SETD5 CTH GLA DDC DLAT AGXT LPO MGAM ASNS PMC8573099__F7 Branched-Chain Amino Acids Catabolism Pathway Regulation Plays a Critical Role in the Improvement of Leukopenia Induced by Cyclophosphamide in 4T1 Tumor-Bearing Mice Treated With Lvjiaobuxue Granule EIF4EBP3 YARS2 IMPA2 BCAT2 CTH DLD LDHB PAH GAD2 GCK PMC8423577__F3 Remodeling of Macrophages in White Adipose Tissue under the Conditions of Obesity as well as Lipolysis STAT3 GDF3 COX2 SPHK1 SOCS3 PMC9020200__F3 Cardiovascular informatics: building a bridge to data harmony RAPGEF2 SP1 SAMM50 TMEM11 PACSIN1 PMC6533522__F2 SUMOylation‐mediated signalling pathway of cardiac hypertrophy HSF2 SUMO1 SUMO3 SUMO2 PMC12016104__F1 Metabolic pathway of the engineered G RPE PDC TNLG7C PMC8663935__F1 Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions RHEB MLST8 TSC1 ULK1 TFEB PTEN GRB2 DEPTOR PMC8663935__F2 Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions ATG101 WIPI1 ATG10 ATG3 ATG16L1 ATG12 ULK1 UVRAG AMBRA1 ATG5 PMC8266377__F2 Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy STAT1 MAVS STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IRF7 JAK1 TYK2 PMC11973335__F1 MPC mesengenic and angiogenic differentiation pathways are mutually exclusive C2 DLL4 MSC PMC6996551__F1 Cyclin D1–CDK4/6–RB and PI3K/AKT/mTOR pathways in BC TSC2 CDK6 EGFR MTOR CCND1 CDK4 PMC6384427__F2 NFKB and IRF3 signaling pathway regulation by miRNAs implicated in inflammatory diseases TRADD TAB3 IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC5979333__F2 The NF2/merlin signaling pathway DCAF1 LIN28B PATJ PALS1 MTOR MYC CTNNB1 LATS1 RHEB CD44 TSC2 LATS2 TSC1 AMOT PMC8856834__F3 Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis BTRC SOX9 CEMIP PMC7997185__F1 NEK1 and NEK2 play key roles in the DDR pathway CDC2 MSH6 ATR ATRIP NEK2 FANCA SSB VHL NEK1 TLK1 MRE11A NPM1 ATM PMC5743230__F2 HYPOXIA AND PLACENTAL DEVELOPMENT HIF1AN CITED2 HEL-S-68p EPO EP300 HIF1A COMMD1 VHL PMC7997185__F3 Possible involvement of NEK6 and NEK7 in DDR ATR NEK6 ATM PMC7997185__F5 Signaling pathway of NEK10 and NEK11 upon DNA damage CDC2 ATR RAF1 NEK11 ATM PMC3934873__F1 Iron Transport Machinery of Human Cells: Players and Their Interactions TF STEAP3 HP CD163 PMC2169177__F10 Schematic view of Ras- and calcineurin-dependent pathways in T cells ZAP70 SOST CD69 RASGRF2 IL2 VAV1 RAC1 PMC4369815__F6 Schematic diagram of the signalling pathways involved in DEHP-induced Beta-cell dysfunction HEL-S-11 ATF4 EIF2A PMC3535184__F4 Ingenuity pathway analysis reveals the close relationship between 14 of 17 of most relevant genes in rectal cancer MMP25 FUT1 ASPN MYOT IFITM1 CLDN3 TNF ANGPTL1 MEF2C CEBPA GDF15 SMPDL3A ETV4 MMP2 CEP72 MB TRIB3 FGF18 CLDN1 PMC7122270__F2 Type I/II cells FADD PMC2593676__F6 Gene expression and metabolite levels in the distal network pathways related to Met- and Trp-derived GS biosynthesis CBL HEL-S-64p PMC5755497__F11 Ingenuity pathway analysis of differentially expressed genes unique to emerin-null cells during transition from day 1 to day 2 of differentiation CDC42 CAV3 EGF TRIO HEY2 PXN APC GNG12 ARHA FLNA ANKRD2 MEF2C HEL114 HIF1AN FOXF1 PI3 MYH7 TTN ALPK3 GRB2 SRC LBP PMC5755497__F12 Ingenuity pathway analysis of genes differentially expressed during the transition from differentiation day 0 to day 1 common to emerin-null cells and wildtype cells MAX SOCS1 ATR TNFAIP3 SMYD1 BOC SMAD4 SOCS3 ANKRD2 BMI1 RB1 HIF1AN ATM MDM2 CAV3 SIN3A PAK1IP1 ANGPT2 CXCL10 CXCL14 ID3 NRG1 CEBPA MBNL3 FOXO1 CASP3 CDK2 TRIM54 SUV39H1 ASB2 RIPOR2 PMC7931689__F2 Identification of a functional network and laryngeal cancer-associated DEGs from the red-green overlapping DEGs POSTN COL1A2 LOX NID2 THBS2 SPARC COL10A1 MYCT1 LAMB1 VCAN PMC9645326__F2 Potential Protective Role of GS-441524, a Metabolite of the Prodrug Remdesivir, in Vaccine Breakthrough SARS-CoV-2 Infections ALB CTSA ACE2 PMC8687399__F10 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy BAX INA CASP12 CASP3 HEL-S-11 TRAF2 PMC7944918__F8 Gene ontology enrichment analysis of co-upregulated DEGs in both systemic sclerosis and lung cancer CD40 TIRAP CTSK TLR9 CD14 IL6 TRAF3 TRAF6 RAC1 TLR4 LBP CD6 FADD PMC8083443__F1 Immunohistochemical analysis of Nuclear Factor-kappa B (NFKB) between follicular and plexiform ameloblastomas: A pilot study SYK LTA LEP LTBR TRADD TIRAP LAT CD14 BLNK TRAF3 MYC DAO POR LTB BCR LYN CYLD PMC3035636__F1 Targeting Metabolic Remodeling in Glioblastoma Multiforme HEL-S-133P HK2 MYC HEL-S-26 PMC12124647__F7 Relationship between Oxidative Stress and Angiogenesis in RA CGAS OGDH XDH TNF MPO PMC12124647__F8 Angiogenesis in rheumatoid Arthritis: Pathological characterization, pathogenic mechanisms, and nano-targeted therapeutic strategies SPHK1 MTOR VEGFA SRC PMC3245201__F1 Topography and signaling pathways triggered by selectin ligands in neutrophils CD44 SYK BTK PLCG2 c-fgr LYN PMC12124647__F6 Impact of Glycolysis in RA Angiogenesis F2 ARHA PMC12124647__F4 Abnormalities in EPC Phenotype and Vascular Barriers in RA Synovium CXCL13 CXCR5 VCAM1 PMC6581914__F10 Scheme and working model PC IAPP PMC6966445__F1 Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathways (simplified) STAT3 IFNGR1 STAT2 IRF9 CRKL IRF7 STAT1 IFNGR2 IFNAR2 IFNAR1 RS1 JAK1 TYK2 PMC3037729__F1 Interaction between PI3K/Akt and Wnt signaling pathways mediates diverse cellular effects through downstream messengers FOXO1 GSK3B MTOR CTNNB1 PMC6830099__F6 Putative model for the role of WIP1 in HR and in PARP inhibitor sensitivity BRCA1 PARP2 PARP1 PMC3944966__F1 p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock PAH ENO1 PMC4243732__F1 Cyclooxygenase and 5-lipoxygenase pathways with special reference to aspirin exacerbated respiratory disease GPR17 LTA COX1 PMC2631376__F3 Hypothalamic Malonyl-Coenzyme A and the Control of Energy Balance FAS POMC NPY AgRP PMC2919048__F7 Comparative Analysis of Extra-Embryonic Endoderm Cell Lines LTBP1 SMAD1 THBS1 DKFZp781O1323 ROCK2 SP1 NODAL ARHA PITX2 TGFBR1 IFNG RBX1 SMURF1 TUB FST SKP1 SMURF2 PMC2919048__F8 Comparative Analysis of Extra-Embryonic Endoderm Cell Lines MAX ECSIT JUN FAS RAF1 EGFR CD14 FLNA NGF MAP3K7IP1 MOS PAK1 HEL-S-162eP NLK GRB2 BDNF TRAF2 PATE2 PMC8199681__F1 Molecular Details of the Frataxin–Scaffold Interaction during Mitochondrial Fe–S Cluster Assembly FXN ISCU ABCB7 PMC2277413__F4 Gene Network A AURKA RAB4A EDN3 CITED2 KLF6 EBP MYBL2 PTEN TLE2 SAP30 SMARCC2 TRIM28 NCOR1 PMC7346436__F8 Pathway signalling network of the common gene regulators associated with the top-ranking 100 CpG sites JAK3 PTRH2 MAPK3 KCNB1 SNAI1 ARID1B PI4KB PIP4K2A RIF1 SET OSBP AURKB PRKX WASF1 MAP3K5 BAIAP2 BHLHE41 DAAM1 RAP1GAP BAD CDON SETBP1 EGFR PTEN RUNX2 MEF2C CTNNB1 MAST2 TPR BTK PLCG1 BTRC SLIT2 ROCK1 CTBP1 HDAC5 SRGAP3 ATM CAMK4 FOXP3 MAML2 BCORL1 ERBB4 GJB2 NCOA1 RBPJ PTPRG NR3C1 MEF2D PPP1R14A ARHGEF18 NCOR2 PKD1 CAMK2D RELA SSH1 LYN ROBO4 PMC2277413__F5 Gene Network B PAX3 RB1 HDAC1 CREG1 SP1 KLF6 HEL-S-29 HCFC1 KLF10 CDKN2B ID1 BDP1 PMC4038991__F4 Circadian Redox and Metabolic Oscillations in Mammalian Systems PER3 NPAS2 PER2 PER1 PDE1B CRY2 CRY1 NAMPT PMC7093020__F2 Overview of crosstalk pathways associated with renal fibrosis and inflammation EGF SMAD1 TGFA EGFR SMAD2 IL18 SMURF2 PMC4669103__F4 Role of Innate and Adaptive Immunity in Cardiac Injury and Repair FYN TLR4 IRF3 MYD88 PMC3228878__F1 Several types of TG2-containing adhesive / signaling complexes present on the cell surface LRP5 LRP6 ARHA SRC CTNNB1 PMC6944044__F2 Linc00152 is involved in protein activation BRCA1 EGFR PTEN NCL PMC7492540__F1 Schematic of known pathways regulated by AR in various breast cancer subtypes FOXA1 PTEN WNT7B MYC SOX4 CTNNB1 PMC9250250__F5 Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method CYB5R3 TPD52L2 PFDN2 ARHGAP1 HEL-S-21 GNG12 PML ATP2A2 TUBB6 RAB5B DUSP3 HEL-S-128m CLU HEL-S-2a HEL-S-11 STX1A HEPACAM TUBB4A BAX ACOX1 FBN1 HEL-S-133P APOE S100A6 TLN2 F13A1 PCBP1 TNF CD44 PDHX FKBP4 CCT7 GFAP COL6A1 ELAVL1 HEBP1 SNCG PPP2R2A PTGES3 PMC8852695__F8 Short‐term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF‐beta signaling GSC IRF7 NODAL PMC8454773__F1 Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals UCP2 FPGS PMC7431475__F11 Additional examples on TA-based MECs MME SMO PMC11703843__F1 LLPS and signalling pathways in the cytoplasm of healthy liver cells and HCC cells FRMD6 TAB3 IRAK1 IRAK2 TRAF6 IRAK4 PMC8756734__F1 Biological Clock Pathways Are Complex and May Yield Variable Outcomes EPO MTOR SIRT1 PMC10036500__AF1 MACF1 overexpression in BMSCs alleviates senile osteoporosis in mice through TCF4/miR-335–5p signaling pathway APC TCF4 CTNNB1 PMC3291787__F1B Targeting the EGFR signaling pathway in cancer therapy EGF HBEGF TGFA BTC HRG PMC6682713__F1 LncRNAs regulate angiogenesis through modulating multiple signaling pathways STAT3 ANGPTL4 HIF1A MTOR VEGFA AGGF1 PMC6707130__F1 Developmental Alcohol and Circadian Clock Function VIP BDNF AVP PMC10675562__F6 HS potential inhibitory mechanism of GA via TGFB/Smad signaling pathway SMAD2 SMAD4 PMC2724779__F1 Complexity of sphingolipid biosynthetic pathways CERS3 CERS5 CERS1 CERS2 CERS6 PMC7189493__F7 Effect of X-rays on transcript expression of rat brain microvascular endothelial cells: role of calcium signaling in X-ray-induced endothelium damage PLN CAV3 BCR CD33 MCU PMC7930566__F2 Schematic portrayal of the possible mechanisms of mifepristone as a chemo-sensitizing agent for glioblastoma BAX BCL2 MGMT PMC4421107__F1 Energetic and biosynthetic functions of de novo lipogenesis (DNL) in the control of metabolic homeostasis ACLY FAS CIC PMC8600187__F4 Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity IL13 TLR4 NQO1 MAL IL4 IL6 MYD88 PMC8259581__F1 Corrigendum: Signaling Pathways Regulating Thermogenesis TFAM ZC3H10 UCP1 ATF2 NRF1 PMC9322645__F8 Molecular Processes of Dodder Haustorium Formation on Host Plant under Low Red/Far Red (R/FR) Irradiation CAD PRX H1-0 PMC8259581__F2 Corrigendum: Signaling Pathways Regulating Thermogenesis SMAD1 DKFZp781O1323 COX2 BMP7 WNT10A PMC7295575__F5 Summary of the proposed pathway PIEZO1 NACA2 ADAM10 NOTCH1 PMC8817700__F1 Targeting Toll-Like Receptors in Sepsis: From Bench to Clinical Trials HMGB1 TBK1 TIRAP TLR9 IRAK1 TLR5 IRF3 IRF7 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC3432650__F1 How does Lin28 let-7 control development and disease? LIN28B DGCR8 LIN28A DROSHA PMC3770684__F3 SNP (–617C>A) in ARE-Like Loci of the NRF2 Gene: A New Biomarker for Prognosis of Lung Adenocarcinoma in Japanese Non-Smoking Women KEAP1 MAF MDM2 ABCG2 PMC4576673__F5 Summary of endogenous pathways of AHR ligand synthesis IF2B1 AHR IL6 PTGS2 VEGFA PMC5578145__F8 Changes in the photosynthetic electron transfer chain, Calvin cycle, and biosynthesis pathway of sucrose and starch in response to rapid changes in temperature in M HEL-S-162eP PC FES PMC4600508__F2 Schematic overview of the multiple signaling pathways to apoptosis, necroptosis and autophagy RIPK3 TRADD MLKL TNF FADD PMC6288939__F4 Expression differences in males and females in response to reduced insulin signaling for immune response genes TH EPO DAP PAH SPG20 ATF2 POLE FADD PMC7677403__F2 Toll-like receptors (TLRs) mediated signal transduction pathway TLR3 TLR9 TLR8 IRF3 IRF7 TLR7 MYD88 PMC9685408__F2 Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation SOX17 PROX1 CHD4 ETS2 FOXC2 SOX18 PMC7677403__F3 cGAS/STING- mediated signal transduction pathway TBK1 CGAS IRF3 IRF7 PMC6288939__F6 Expression differences within the IIS/TOR pathway for the four comparison types RPS6 PTEN MTOR MYC PMC12061282__F10 Schematic depicting the mechanisms by which miR‐31‐5p regulates M1/M2 balance in autoimmune dry eye P2RX7 NOS2 PMC5770784__F1 Schematic drawing of the interactions between AB(1‐42) and IGF‐I receptor signaling GSK3B IGF1R BDNF PMC7677403__F1 RIG-I-like receptors (RLRs) mediated signal transduction pathway MAVS IRF3 IRF7 PMC7795494__F2 Comparison between the opposite effects of probiotics and early-life use of antibiotics in NOD mice PLN MLN IL10 TLR4 MYD88 PMC8070500__F2 JNK pathway in CNS pathologies ATF3 KLF9 PMC8070500__F1 JNK pathway is conserved between mammals and flies TF JUN TNF FOS UNK PMC3161872__F1 Summary of TNFR signalling TRADD TNF TRAF2 FADD PMC4470683__F7 Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action STK11 SP1 CDKN1A MYC PMC4988307__F1 Sulforaphane regulates Keap1-Nrf2-ARE signaling pathway and induces phase II metabolic enzyme expression KEAP1 SFN PMC9524954__F7 Alpha-KG production pathways that add net carbons to TCA cycle from glutamine GOT2 GPT2 SLC25A1 PMC6571700__F8 Signaling pathways modulated by EV miRNAs associated with T2DM SOCS1 IGF2BP1 INSR FOXO1 ACVR1 TGFBR3 IGF2BP2 NOTCH2 KAT2B NOTCH1 PMC2516940__F2 Sepsis and insights from clinical trials TLR4 MAL IRF3 MYD88 PMC5361607__F1 PRKCD-AKT-MTOR-ULK1 signaling pathway for autophagy suppression in cisplatin nephrotoxicity PDPK1 ULK1 MTOR SRC PMC3390502__F8 Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells CCL20 SIRT1 IL1B PMC7677403__F4 Inflammasome-mediated signal transduction pathway NLRP3 TLR3 AIM2 IFI16 IRF3 IRF7 PMC8163070__F6 Phloretin protection against pathogen-induced mucin 5AC, oligomeric mucus/gel-forming (MUC5AC) MAPK1 MUC5AC TLR4 EGFR MAPK8 NOX4 MAPK3 PMC3761286__F1 Diagram showing Na-K-ATPase control of cell function by ouabain via its ion transport and signaling functions EGFR HEL-S-11 GRB2 SRC PMC8120650__F3 Autophagy-related signaling pathways are involved in cancer (Review) SBK1 SGK1 BNIP3 PTEN MTOR MYC DEPTOR RHEB MLST8 TSC2 RICTOR TSC1 FOXO3A PLP2 PMC8120650__F4 Autophagy-related signaling pathways are involved in cancer (Review) TSC2 ULK1 MTOR PMC8120650__F5 Autophagy-related signaling pathways are involved in cancer (Review) CDC42 LAMP2 EGF KEAP1 COX2 BCL2 ATF4 EIF2A ATG5 PMC6923169__F2 Biosynthesis of N-glycoproteins in eukaryotic cells GAL AIG1 FUT8 ALG6 ALG10 ALG13 ALG1 ALG3 PMC6817752__F11 Schematic showing the proposed mechanism of action and regulation of HNRNPK/miR-7 KLF4 IDE ABCG1 SP1 INSR HNRNPK PMC7463546__F1 NFKB signaling pathway and anti-multiple myeloma (MM) drug targets CD40 EGF LTBR EGFR RELA RELB TRAF5 TRAF3 TRAF6 TRAF2 PMC8109088__F8 Proposed model illustrated the role of hsa_circ_0110102/miR-580-5p/PPARA/CCL2 signaling in regulating HCC metastasis NR1C1 CCR2 CCL2 PMC3086058__F1 Representation of genes of the vascular endothelial growth factor (VEGF) signaling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib, and cilengitide are known to act TIMP3 RAF1 FRS2 SOS1 NRP1 VEGFA FGF2 CRK VEGFB PIGF CSK FLT1 KDR GRB2 PMC9599894__F5 Radiotherapy-Related Gene Signature in Prostate Cancer CCL23 MUC15 CD3D EPS8L2 FCGR2B TNFRSF14 CCR7 AMFR BTLA CD3G CD6 CD3E PMC11209433__F5 Interactions among genes involved in the type 1 interferon signaling pathway using STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) CXCR3 CXCL1 IFIT1 IFIT3 TLR9 IL36A TRAF3 CCL2 CSF3 CXCL3 XCR1 HLA-DRA MME IL36RN OASL ACKR3 TRAT1 MX1 ISG15 FOXP3 IL31 IL1F10 IL17F CCRL2 FBXO6 CCL11 SELE CPA3 RNF31 CXCL2 PTGS2 RSAD2 OAS3 CXCL10 CXCL14 NCR3 CXCL11 CBL HDC MAP3K1 NFKB1 CXCR5 TRIM6 MGAM GPX7 LEF1 PMC8450384__F4 Glucose Metabolism and Glucose Transporters in Breast Cancer HEL107 HEL-S-133P PHGDH HK2 PMC5899410__F3 TREM2 mediated innate immune regulation in Alzheimer’s disease TREM2 TNF IL1B CTNNB1 PMC4232216__F1 BMP Family and Signaling Pathways BMP15 BMP10 SMAD1 DKFZp781O1323 BMP3 SMAD6 SMAD4 BMP7 GDF6 BMP6 gdf7 BMP1 GDF11 BMP4 BMP2 BMP5 PMC5468173__F4 An illustration of potential mechanisms in injury-induced vascular intimal hyperplasia is depicted TLR4 MYD88 PMC9163386__F6 Component 1 Inhibitor Missense (Val480Met) Variant Is Associated With Gene Expression and Sepsis Development in Neonatal Lung Disease IL10 PLAT MASP2 KLKB1 C1S PLG F11 ELANE IL6 C4A C4B_2 TNF PMC7354650__F4 Network Pharmacology Approach to Investigate the Active Compounds and Mechanisms of Musk for Ischemic Stroke POR NR1i1 OPRK1 NR3C2 DRD1 ADRA2A HIF1A WNT4 INS MED1 HDAC2 NR3C1 PMC3557799__F3 Structures of Get3, Get4, and Get5 Provide New Models for TA Membrane Protein Targeting GET1 GET4 GET3 PMC9602906__F8 Exosomes Derived from Adipose-Derived Mesenchymal Stem Cells on Pyroptosis and Regeneration of Injured Liver GSDMD NLRP3 TLR4 CTNNB1 PMC4641524__F4 Differential Somatostatin Receptor (SSTR) 1-5 Expression and Downstream Effectors in Histologic Subtypes of Growth Hormone Pituitary Tumors3.1 SSTR2 AIP SRC PMC3357464__F3 Scaffolds can organize pleiotropic kinases into stimulus-specific signaling modules to direct them to one specific pathway MAP2K4 TAB3 TRAF2 PMC5114727__F1 Enzymatic steps of the P PPCS PPCDC PMC11119900__F3 PAI-1 alters TME and regulates tumor cell migration and invasion DDR1 PLG PMC9506158__F3 ORF45 Protein of Kaposi’s Sarcoma-Associated Herpesvirus and Its Critical Role in the Viral Life Cycle TBK1 TSC2 EIF4B IRF7 MDM2 PMC10041561__F17 Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs FABP5 TLR3 TRPV1 MX2 IRF3 MX1 FAAH OAS1 TNF PMC11206879__F3 Alterations in major signaling pathways that have been identified in OS development and metastasis: PI3K/AKT/mTOR, JAK/STAT, Wnt/Beta-catenin, NOTCH, Hedgehog/Gli, TGFB, MAPK, and receptor tyrosine kinases (RTKs) STAT3 LRP5 SMAD6 SMAD4 LRP6 PTEN MTOR SUFU PTCH1 VGF SHH SMO GRB2 HES1 PMC7365123__F1 Putative association between ACE2 shedding after SARS-CoV-2 infection and the poor outcomes in elderly COVID-19 patients with pre-existing age-related cardiovascular, cardiometabolic and cardiorenal diseases TMPRSS2 MTOR ACE2 PMC10041561__F15 Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs PROC TNF PMC6529740__F2 Potential and confirmed phenotypic features of C9orf72 HRE-associated microglia in FTLD/ALS TREM2 RAN TYROBP C1QB CD68 C9orf72 PMC8000072__F6 Proposed pathway by which SCFAs regulate lipid metabolism in a sex-specific manner in Long–Evans rats TG ACAT2 CYP7A1 PMC2652039__F8 Tumor Necrosis Factor-like Weak Inducer of Apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta activated kinase 1 TRAF5 TRAF1 VCAM1 TRAF3 CCL2 TRAF2 PMC5234130__F4 Terpene biosynthetic pathway, and heatmaps displaying the expression (log2 FPKM) of enzymes involved in the different reaction steps TRO IPP ME2 MVD MVK PMC8848383__F8 Activation of the AKT/GSK-3B/Beta-catenin pathway via photobiomodulation therapy promotes neural stem cell proliferation in neonatal rat models of hypoxic-ischemic brain damage NFKB2 MYC CCND1 CTNNB1 PMC9219473__F6 Iturin A Rescued STb-R-Induced Pork Skeletal Muscle Growth Restriction through the Hypothalamic-Pituitary-mTORC1 Growth Axis IGF1 GHRH IRS1 EIF4E PMC4760220__F7 AAV backbone alone has no effect on interferon activation IFNG BAX PSMB8 IRF9 IFIT1 IFIT3 PIAS1 IRF1 TAP1 JAK1 TYK2 PMC6438741__F3 At the intersection of DNA damage and immune responses BAX SYK SPIC BAD PIM2 PIM1 BLNK IL7R RAG2 IRF4 PREB FOXO1 ATM PMC4891443__F5 Regulation of insulin-like growth factor 1 receptor signaling by microRNA-4458 IGF1 MMP3 IGF1R PMC7711227__F2 CaMK, MAPK/ERK, and CaN Signaling From L-VSCCs to Transcription SIK1 CRTC1 PMC9516679__F9 Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between lamininG2 and integrinB1 CDH2 LAMC2 PMC6438741__F6 At the intersection of DNA damage and immune responses HEL-S-62p CRTC2 ATM UNG PMC7825147__F2 Tumor suppressor and promoting effects of the TGFB pathway BAX ANGPTL4 ID2 COX2 EGFR APC RAD17 ATM ID1 ID3 PMC6459935__F1 Bioinformatics analysis of direct ERRA target genes in mouse liver NR1C1 RXRA PMC8828488__F1 ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis CD44 NLRP3 TXNIP CNP IL1B PMC7825147__F1 Transforming growth factor B (TGFB) signaling pathway TF SMAD2 SMAD4 ARHA MTOR UNK PMC6206158__F1 Complement activation pathway and regulation MASP1 C6 CD59 FH MASP2 HEL-S-62p C1S CD46 C4A C4B_2 CR1 PMC8257394__F4 Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Zao-Jiao-Ci in the Treatment of LSCC NAPA USP42 VWF TH TCHP OSM TSHR BANP PATJ CTSA HEL-S-92n CRK NRG1 EZR GALNS ADAM12 RPL4 PMC6540932__F6 Network view of infected dendritic cells SYK RAF1 RELB NR1C2 MTOR CSF3 IFNG RNF125 TLR4 NOD2 IL18 NOD1 ISG15 SRC EIF4B UBC IL10 IF2B1 ARRB2 IL12A RAC1 EIF4E RHEB TSC2 MAP3K7IP1 TLR3 CCL4 PMC5135602__F1 PPARD mediated gene regulation IFNG PDK4 BMP4 JAG2 IL6 CPT1A CTNNB1 PMC3250080__F1 CR-associated signaling and some of its key players RHEB IGF1 IGF1R GHR IRS1 PMC8820534__F1 High Cysteine Diet Reduces Insulin Resistance in SHR-CRP Rats HEL-S-182mP CTH pcap SQOR HEL-S-61p SUOX PMC4822853__F3 Functional Response of B Cells to Antigenic Stimulation: A Preliminary Report of Latent Tuberculosis IFNG IL24 IL27 IL4 IL6 PMC3023615__F2 In fibroblasts, Nod2 senses bacteria at the plasma membrane and recruits the autophagic machinery through direct interaction with ATG16L1 ALG5 ATG12 NOD2 PMC4309023__F6 Core Hedgehog pathway and its cross talks SUFU DHH SHH IHH SMO PTH PMC5578810__F2A Fanconi Anemia Protein Interaction Network: Casting A Wide Net ATR REV1 ATRIP PCNA CLK2 PMC3690688__F8 Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium KCNE3 CFTR PMC9144222__F10 Crassolide Induces G2/M Cell Cycle Arrest, Apoptosis, and Autophagy in Human Lung Cancer Cells via ROS-Mediated ER Stress Pathways BAX CASP3 ATF4 EIF2A CCNB1 PMC6862548__F1 Pathways activated by several dysregulated hormones in central obesity STAT3 BAX BAD SOS1 ADIPOR1 ADIPOR2 PTEN MTOR SOCS3 FYN NFKB1 RELA CHUK NPY GRB2 REL PMC6862548__F2 Estrogen biogenesis, and its metabolism SP1 FLT1 SRC PMC8622245__F1 An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine Adjuvants TLR4 TRAF6 MYD88 PMC7919658__F3 Oxysterol and BA profiles by the hepatic endocannabinoid and immune system in male mice CYP8B1 CYP7A1 FGFR4 CYP7B1 CYP27A1 MYD88 PMC4668392__F1 Multiple regulation pathways and pivotal biological functions of STAT3 in cancer CDC42 STAT3 SRC RAC1 PMC11215460__F1 Overexpression of Plakophilin2 Mitigates Capillary Leak Syndrome in Severe Acute Pancreatitis by Activating the p38/MAPK Signaling Pathway AQP3 PKP2 CTNNB1 AQP5 PMC8948438__F2 Exploring the Pharmacological Mechanisms of Xihuang Pills Against Prostate Cancer via Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo SYK MYB BAD RBL2 CYC1 PTEN CD19 RAC1 RHEB TSC2 BRCA1 CD37 MDM2 ACR PMC2683291__F4 Mammalian target of rapamycin (mTOR) signalling cascade RHEB TSC2 MTOR EIF4E PMC2757047__F3 Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity CDK5 CCK SEMA3D VLDLR APOE TWIST1 PMC5362541__F2 Inhibition of cancer antioxidant defense by natural compounds RBX1 KEAP1 PMC4582071__F3 Intracellular pathways to canalicular and basolateral plasma membranes ABCB11 ABCB4 ABCC2 ABCB1 PMC12064105__F7 Mechanism diagram of XSBO against AD (drawn by Figdraw 2 ALOX5 SMS COX1 PMC8727999__F2 Concepts in Multifactorial Etiology of Developmental Disorders: Gene-Gene and Gene-Environment Interactions in Holoprosencephaly TCTN3 CDON SMAD2 NODAL TGIF1 IFT172 MKS1 FOXH1 SIX3 PTCH1 FGFR1 SHH GAS1 ZIC2 PMC8329661__F2 Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? BAX CDKN2A CDK6 APAF1 CDK4 PMC8329661__F3 Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? EGFR GIP PTEN MTOR KRAS PMC5072448__F1 Molecular mechanisms and signaling pathways of ferroptosis IREB2 VDAC3 FLT3 SLC3A2 ACSF2 GPX4 LPCAT3 FACL4 SLC7A11 CS FTH1 FTL HEL-S-102 PMC9303011__F2 Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancer TF MAX SET PMC7044202__F9 MAPK regulated induction of cytokines in IL-33 stimulated ILC2s IL33 PTEN MTOR MYD88 PMC11019147__F4 Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging PLCG1 GSK3B NFATC1 TRAF6 RAC1 PMC8329661__F5 Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? COX2 PTEN KRAS PMC7480187__F7 Alleviation prostate cancer progression via overexpresion of RIP3 CDC2 MLKL CCNA2 CCNB1 PMC10740485__F7 The proposed mechanism of Nrf2 in osteoporosis DCSTAMP NFATC1 TRAF6 PMC11019147__F3 Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging TET2 KLF2 ULK1 BNIP3 BCL2 TRAF6 PMC11019147__F1 Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging PLCG1 ORAI1 NFATC1 TRAF3 TRAF6 PMC5508477__F6 Representative scheme of the mechanisms involved in the induction of cell cycle arrest and senescence.MPM cell lines are frequently deleted in CDKN2A/ARF gene, coding for both p16INK4a and p14ARF CDK6 MDM2 MYC CDK4 PMC9454318__F5 Alpiniae oxyphyllae fructus possesses neuroprotective effects on H2O2 stimulated PC12 cells via regulation of the PI3K/Akt signaling Pathway PIK3CA PAXIP1 PGR EGFR SLC30A4 GSK3B PIK3R1 IGF1R PSEN1 CTSC RORA COL1A1 CCNE1 ID4 FGFR1 KDR ACHE ID2 SCD ID1 ID3 HEL-S-130P PRKDC PSEN2 CASP3 CDK2 BCL2 CYP46A1 PMC8306267__F2 Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria HEL-S-62p F2 PLG PMC5143376__F8 Hypothetical model of TMEM2 exerting its antiviral functions IRF9 JAK1 OAS1 TYK2 PMC4981961__F6 Phagocytosis and proteasome pathways VASP SELL LAT INA PMC6599063__F4 Simplified schematic representation of the affected pathways in an emerging honeybee worker that impact Varroa and DWV symptoms via their interactions SMAD2 MTOR BCL6 RAC1 PMC5683946__F2 NMD degrades mRNAs encoding UPR components BAX ATF3 FSD1L ATF4 EIF2A XBP1 TRAF2 PMC4742123__F2 Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer MID1 SRC PMC10217556__F1 Urothelial Oxidative Stress and ERK Activation Mediate HMGB1-Induced Bladder Pain HMGB1 CD74 TLR4 MIF CXCR4 PMC3883113__F6 Neurodegenerative diseases and widespread aggregation are associated with supersaturated proteins LPL IDE CASP9 BAD FAS CASP8 OCA2 CASP12 APOE GSK3B SNCA TNF CDK5 CASP3 APP APAF1 FADD PMC5480880__F6 Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies ERBB3 CAST CRB2 BRAF ERBB2 PTEN GRB2 KRAS EPHA7 PMC6431505__F6 Schematic graph of the proposed cardioprotective mechanism of H2 when rats were exposed to CIH ATF4 EIF2A XBP1 PMC11046830__F2 Glycocalyx degradation in LPS or septic conditions TF VWF TFPI APC PMC11046830__F3 Oxidative stress response in ECs NOX5 NLRP3 FES POLDIP2 MIF NOX4 PMC5683946__F6 NMD and apoptosis have a complex regulatory relationship I MAX SGK1 ATF2 GADD45A UNK PMC8968663__F1 Revolution of vitamin E production by starting from microbial fermented farnesene to isophytol IPP PC IDI1 PMC11046830__F4 Cascade of effects resulting from the release of IL-33 under the action of endothelial injury and other factors STAT3 IL33 MMP2 VCAM1 MMP9 CCL1 MPO PMC12192587__F4 Muscle Fiber Phenotype Shifts in Response to ECM Coatings CD36 NRF1 CPT1A ACADM PMC4348787__F7 Fungus-induced changes in expression of the wheat jasmonate biosynthesis pathway LOX SI PMC8375153__F1 Mechanisms of Sevoflurane-Induced Neuroinflammation SOCS1 SOCS3 PMC11968360__F1 Organoid models of ovarian cancer from three different sources ITGB6 STAT2 HEL-S-133P FOXK1 HK2 BRCA2 UCP1 PMC12211009__F10 BACE1-AS in the regulation of the propagation of C BCL2 IRF3 PMC4452147__F3 Schematic illustrations of a double-negative feedback loop and the ceRNA pathway HMGA2 PTEN PMC11506204__F3 Signal pathways of astragaloside IV in breast cancer VAV3 FOXO1 RAC1 PMC11506204__F1 Signal pathways of calycosin in breast cancer BAX RASD1 IGF2BP1 BATF RAB27B FOXP3 PMC11506204__F2 Signal pathways of formononetin in breast cancer IGF1 PTEN FPR2 MTOR CDK4 PMC2722780__F8 Putative BK-BKAP interactions derived from the BK interactome in mouse cochlea BAD LIN7C HEL-S-162eP SET PMC4048824__F2 Pathways for sulfide biogenesis and clearance RHD PMC3792444__F1 Induction of migratory heterogeneity during priming CD44 CD40 IFNG CXCR3 CD80 EZR KLF2 FOXO1 GC CCR7 CXCR5 BCL6 PMC8346999__F8 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases UBR1 BRCA1 LIMK1 RIPK1 TRAF1 BMX NEDD9 PMC8346999__F9 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases UBR1 PINK1 UBR4 PARL PMC8346999__F7 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases UBR1 ATE1 PMC8346999__F1 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases UBR5 UBR1 UBR4 NTAQ1 NTAN1 ATE1 PMC9368818__F9 Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy TRIAP1 CASP3 TAF9 PMC3342370__F1 Role of autophagy during innate immunity ATG12 ATG5 IL1B PMC11007101__F2 Therapeutic prospects of nectin-4 in cancer: applications and value ADAM17 SRC PMC4693592__F2 Monocytes from MS patients cluster independently from HV and display enhanced inflammatory pathways TREM1 PMC10910240__F7 Mechanism of aerobic exercise combined with canagliflozin therapy against ISO-induced CHFCanagliflozin combined with aerobic exercise therapy modulates protein kinase activity CYP26B1 ALDH1A2 CYP1A1 PMC11534688__F11 Blestriarene C exerts an inhibitory effect on triple-negative breast cancer through multiple signaling pathways BAX BAD GRB2 PMC9114368__F8 Illustrative model to show the mechanism of circLIFR in HCC AGO2 CTNNB1 PMC9084550__F2 Signaling pathways and therapeutic approaches in glioblastoma multiforme (Review) EGF TCF3 EGFR APC IQGAP1 GRB2 CCND1 LEF1 CTNNB1 PMC4438184__F10 Aldosterone-induced inflammatory responses: role of the ADAM-17/TGFA/EGFR axis and modulation by paricalcitol STAT1 TGFA ADAM17 EGFR PMC7424765__F1 Postulated targets of action of B2-adrenergic agonists in DOK7 patients MUSK LRP4 PMC6291477__F2 AHR signaling pathway AHR CYP1A1 PMC9368818__F3 Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy TAF1D TAF5L TAF7L TAF4 TAF15 TAF8 MDM4 TAF12 TAF9B TAF1 TAF13 TAF6 TAF1B MDM2 TBP TAF3 TAF10 PMC10180667__F4 “Components-targets-pathways” network NOS2 MCL1 GSK3B PIK3R1 PRKCZ HIF1A MAPK9 STAT1 ITGB1 CCNE1 NFKB1 TLR4 PRKCA CHUK MMP2 CDK2 GCK PMC10180667__F5 Effect of FS on toll-like receiver signaling pathway CD40 TIRAP CTSK TLR9 CD14 IRF3 IRF7 TRAF3 TRAF6 IRAK4 RAC1 MYD88 TLR3 LBP FADD PMC6085483__F2 Metabolic reprogramming of cancer cells in the tumor microenvironment (TME) GLS PTEN HIF1A TIGAR SCO2 MTOR MYC PMC6085483__F1 Metabolism is a key feature of every quiescent cell TG FAS MAL MTOR PMC3581603__F6 Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells RPS6 BAX MTOR PMC8511446__F5 Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome SIRPA VAV1 ARHA RAC1 MERTK PMC8210610__F8 Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition MVP CTSK NFATC1 MMP9 PMC4001531__F4 Melanoma NOS1 expression promotes dysfunctional IFN signaling BAX PSMB8 IRF9 IFIT1 BRAF IFIT3 IRF1 GRK4 ADRBK1 FYN RAP1A JAK1 TYK2 PMC6350303__F9 Molecular mechanism of ZNF326-mediated regulation of Wnt signalling ZNF326 APC AXIN1 TCF4 HDAC7 PMC7497304__F1 Models for the interactions between tumor cells and the tumor microenvironment in the brain STAT3 CSF1 CCR2 PTEN CTLA4 CCL2 TNF PMC9375293__F5 Targeting purine metabolism in ovarian cancer DHFR MTOR PMC5094991__F7 SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline EGF ORAI1 STIM1 EGFR TRPC1 PMC9375293__F1 Targeting purine metabolism in ovarian cancer PNP ADSL ADA PMC4877093__F2 IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling CDC42 SMAD2 GSK3B VTN MTOR CTNNB1 PLAT MDM2 MMP7 SP1 LIMK1 PLAUR LRP5 PLG HEL-S-28 VAV1 VEGFA ARHA RAC1 DOCK1 EIF4E HRAS CRK MAP3K7IP1 PAK1 NLK GRB2 WIF1 CP NCL PMC9375293__F2 Targeting purine metabolism in ovarian cancer STAT3 PMC5584303__F2 Epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer FOXM1 SP1 E2F8 YY1 UHRF1 PMC3773757__F6 Summary of the convergence of the E2–ERK and mTORC1 signaling pathways in regulating migration and invasion in LAM patient-derived cells RHEB EIF4B ZEB2 PMC5858571__F4 Schematic of the predicted signalling pathways for HagB-induced MMP production in dendritic cells CD40 SYK RAF1 SHC1 MMP12 SMAD2 IRAK1 HIF1A ATF2 TRAF6 CTNNB1 MYD88 STAT1 PLCG1 PLCG2 CCR6 MMP2 MMP3 CEBPB CREB1 MMP7 SP1 MMP10 CD14 MMP9 IRS1 NFKB1 PLCB1 JAK1 LYN PMC5555084__F1 Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors HEL-S-133P HEL-S-162eP PMC11491726__F2 Relationship of class I HDACs and NOXs in CVDs HDAC3 IFNG HDAC1 STAT1 NOX5 KEAP1 HDAC2 NOX4 PMC10511904__F3 Diagram illustrates how IMD activates various downstream signaling pathways through different CLR/RAMP receptor complexes GAA GC PMC11727316__F6 Molecular basis of Jusvinza’s mechanism of action on neutrophils HCLS1 TIRAP CXCL1 RELB IRAK1 PTEN CCL5 TRAF6 IRAK4 MYD88 HELZ2 NLRP3 SNAI1 TLR4 HSF1 HMGB1 TNFRSF14 MMP10 MBOAT7 LRRFIP2 YBX1 FLI1 MTDH DBI TRAF5 CDC37 TRAF2 PMC3100630__F1 EGFR biology TF TSC2 COX2 EGFR GRB2 PMC7916193__F6 Pathways involved in cutaneous squamous cell carcinoma (cSCC) pathogenesis IRF6 CDK6 EGFR PTEN GRB2 MTOR CCND1 HES1 CDK4 PMC5122717__F7 Model representing the interaction of Arabidopsis thaliana plants/Brevipalpus mites/CiLV-C ERF AGO2 MYC PMC9439701__F8 Specific microRNA Profile and Functional Networks for Children with Allergic Asthma GC RHO INS PMC7344258__F1 Cysteine is a core player in the cellular metabolism VIT HEL-S-162eP PC MYC KRAS PMC165090__F8 Schematic model for the roles of p120 catenin in the signaling pathways leading to growth factor–induced RhoA stimulation and cell migration VAV2 ARHA SRC RAC1 PMC8697442__SF1 Novel targeted co-delivery nanosystem for enhanced ovarian cancer treatment via multidrug resistance reversion and mTOR-mediated signaling pathway CD44 STAT3 BAX PGP MTOR PMC6523794__F4 PPI network for the upregulated genes in the AMPK signaling pathway CAMKK2 SLC2A4 CD36 ADIPOR1 FOXO3A ADIPOR2 LIPE PPP2R1A CPT1A PMC11834262__F8 Graphical abstract illustrating the mechanism of SS in treating BC CSA2 GPX4 EGFR SLC7A11 PMC6457213__F7 Model of cytokine-mediated rescue PIM2 PIM1 PMC3597489__F4 Conjunctival MicroRNA Expression in Inflammatory Trachomatous Scarring ACVR2B FST RBL2 NODAL PMC9107479__F1 Extrinsic and intrinsic apoptosis pathways, indicating pharmacological agents and their therapeutic targets IFNG BAX FADD PMC9352753__F3 Identification of differentially expressed microRNAs as potential biomarkers for carcinoma ex pleomorphic adenoma STAT3 APPL1 SOS1 PIK3R1 SMAD4 HIF1A BBC3 MYC FGFR2 MAPK3 RB1 TRAF4 CDKN2A CCNE1 FZD3 E2F3 FGFR1 HEL-S-5 MMP2 SMO RRM2B MAPK1 MAPKAPK2 ZMAT3 TCF7L2 FZD4 IGF1 BCL2 SESN2 APBB2 MAX FGF14 ABL2 PPP3R1 STK4 NR1C2 RHO TGFBR1 TGFBR2 TPR ARNT2 CCND2 FGF9 THBS1 RRM2 KIT KRAS RAC1 CCDC6 CBL RUNX1 HEL-S-125m ACTN4 IKBKB BMP2 CREBBP EP300 HHIP TRAF6 BCL2L1 PRKCA COL4A2 COL4A1 MDM2 FZD2 CRKL VEGFA FOS CRK CEBPA FOXO1 PTCH2 LAMB3 LAMB2 GRB2 TP73 ATR ADAR HMGA2 PIK3R3 EGFR PAK4 IGF1R PTEN MTOR LAMC1 ITGAV CTNNB1 RARA CCNG1 SHC4 TPM3 ATM CCNB1 CCND1 CDK4 ZFHX3 HSP90AB1 BAX JUN EIF4EBP1 E2F2 FZD7 PTGS2 FGF2 ITGB1 NFKB1 RPS6KB1 RELA SESN3 CASP3 CAMK2G FADD PMC8620413__F4 Lipid signaling in cancer ACLY FAS DGAT1 TSC1 ACSL3 FABP5 CD36 EGFR FASN PTEN LPCAT1 MTOR PMC4076814__F6 Diagram depicting the role of GPX7 in regulating inflammation in esophageal epithelial cells TRADD CXCL1 GPX7 TRAF2 PMC4729111__F2 Metabolic pathway of l-Phe GOT2 PAH DDC PMC6862015__F5 Complement lectin pathway activation CD59 C4BPB VTN CD46 CS ALB HEL-S-99n TXN CFI F10 PROS1 WAS PRKCA ELANE DCN CRP FCN1 CD2 C7 ARRB2 MASP2 CFHR1 CFH PLG F13A1 F11 HEL-S-78p HEL-S-92n C2 C8A FGA PMC9223478__F7 Lysine Deprivation Regulates Npy Expression via GCN2 Signaling Pathway in Mandarin Fish (Siniperca chuatsi) ATF4 EIF2A PMC5713242__F8 Cilia-dependent mTOR signaling RHEB TSC2 TSC1 PMC3174756__F5 Ephrin and neurotrophin signaling pathways in primary neurons NGF PMC6461988__F4 Reconstructed key metabolic pathways of Thermoprofundales based on eight MAGs (a) FH ACD CS PMC3174756__F6 CDK5 (A) and actin (B) signaling pathway in primary neurons NGF FOSB NGFR PMC7556532__F8 HER2-mediated enhancement of Ebola virus entry TYRO3 AXL MERTK PMC5713242__F3 Cilia-dependent Hedgehog signaling KIF7 SUFU PTCH1 SMO PMC7383016__F1 HR pathway in PTEN-deficient EC cells EGF ATR RAD50 RAD51 EGFR BRCA2 PTEN BARD1 MRE11A BRCA1 ATM MDM2 PALB2 PMC8752619__F4 Transcriptional alterations in bladder epithelial cells in response to infection with different morphological states of uropathogenic Escherichia coli P2RX7 RORC MAVS NLRP3 TXNIP ABRAXAS2 BHLHB2 NR3C1 PMC11635689__S1 Metabolic Pathway of Conversion of 5-ALA to Protoporphyrin IX in Gram-Negative Bacterial Cells HMBS FECH UROD PMC7915189__F2 Some examples of signaling pathways involved in OS resistant tumor cells to conventional treatment GSK3B PTEN MTOR CTNNB1 PMC8262654__F1 Banxia xiexin decoction affects drug sensitivity in gastric cancer cells by regulating MGMT expression via IL-6/JAK/STAT3-mediated PD-L1 activity STAT3 PDCD1 EGFR JAK1 MGMT PMC9603448__F6 Engineered Human Intervertebral Disc Model Inducing Degenerative Microglial Proinflammation CCL3 IL6 CCL5 CCL2 CXCL8 PMC10892479__F4 Cytokine storm induced by SARS-CoV-2 proteins (ORF7a, ORF3A, M, and N proteins) mediated by the activation of NF-kB CCL27 CCL19 CCL25 CCL11 CCL21 CCL26 TNF CCL20 CCL17 PMC10892479__F5 Illustrates a diagrammatic representation of the intracellular signaling pathways activated by SARS-CoV-2 infection TLR3 CCL3 TLR8 TLR7 MYD88 PMC5572672__F2 Inherited and Acquired Disorders of Magnesium Homeostasis CASR CLDN16 CLDN14 CLDN19 PMC10892479__F2 Activation of the NF-kB signaling pathway induced by SARS-Co-V-2 and mediated by RIP/TRAF-dependent pathways or RIP-dependent/TRAF-independent IKKB activation LTB MAP3K7IP1 TRADD TLR4 TAB3 IRAK1 TNF IRAK4 MYD88 PMC10892479__F1 NFKB signaling (canonical and non-canonical) pathways LTBR BCR RELA RELB PMC7178465__F2 Danger-Associated Molecular Pattern (DAMP) binds to the Pattern Recognition Receptors (PRRs) expressed on the cytosol or in innate immune cell membranes NLRP3 KMO PMC7178465__F3 Increase of intracellular calcium activates neural nitric oxide synthase (nNOS), causing increased NO levels SIRT3 NDUFA9 KMO PMC8197470__F1 Advantages and Disadvantages of Different Treatment Methods in Achondroplasia: A Review FGFR3 CNP PTH PMC10796102__F6 Action of cerebral lymphatic system in brain diseases due to impaired renal function DUSP5 TH DUSP8 AHR DUSP16 UNK PMC10796102__F4 Binding of CCL19/CCL21 to CCR7 activated signaling pathways in tumor cells, including PI3/Akt, MAPK/ERK and Jak/STAT, which enhanced the expression of VEGF-C and thus promoted lymphangiogenesis CD80 VEGFC CCL19 CCL21 CCR7 PMC10796102__F5 Communication between the gastrointestinal tract and cerebral lymphatic system is mediated directly and indirectly by immune, neural and endocrine pathways CORT AQP4 TREM2 NLRP3 PMC10796102__F3 Possible mechanisms of co-occurring neuroinflammatory response and brain edema in patients with hepatic encephalopathy and potential therapeutic targets for hepatic encephalopathy AQP4 VEGFC TNF PMC7123501__F3 Simplified scenario model illustrating the intrinsic and extrinsic apoptotic pathways BAX CASP9 FAS CASP8 TRADD tmp_locus_29 CASP3 RIPK1 TNF TRAF2 FADD PMC7123501__F4 Simplified scenario model of the necroptotic pathway RIPK3 HMGB1 TRADD TLR3 MLKL TLR4 CXCL1 IL33 RIPK1 TNF TRAF2 IL1B PMC3904234__F1 Interleukin-17 (IL-17) and IL-17 receptor family members and their biological roles IL17RC IL17RB TRAF5 TRAF6 TRAF2 PMC8535311__F2 Genetic and Genomic Pathways of Melanoma Development, Invasion and Metastasis APC GSK3B CCND1 CTNNB1 PMC6617489__F5 Lipotoxicity of VLDLs on mediating maladaptation of calcium regulation to derangement of sarcomere proteins in atrial myopathy ORAI1 VLDLR STIM1 PMC8535311__F3 Genetic and Genomic Pathways of Melanoma Development, Invasion and Metastasis TGFBI SMURF1 SMAD2 SMAD4 SMURF2 PMC4380664__F3 Pharmacological targets and signaling cascades proposed to be important in mediating synaptic plasticity underlying extinction GC RHO SRC BDNF REM2 PMC6061795__F8 An Orc1-2-centered network of DNA damage response in S RAD50 MRE11A ORC6 ORC1L TBP ORC3 ORC2 PMC7251178__F1 TGFB and BMP-7 pathways SMAD1 DKFZp781O1323 SMAD2 SMAD4 BMP7 RHO PMC7251178__F2 Inflammasome complex -dependent and -independent pathways involved in EMT NLRP3 SMAD2 IL18 SMAD4 MYD88 PMC6365421__F1 Chaperone mediated autophagy mechanism GFAP PHLPP1 RAC1 PMC6524193__F5 Functional prediction of key lncRNA-mRNAs network FUS B4GALT1 TUFM NR1C2 MAPK9 HPS3 NOTCH2 ADPGK DCAKD ADAMTSL4 ST3GAL1 MTHFD1 MUC6 ENO3 HLA-G NOTUM COA1 ELOC GCNT1 PMC4081729__F5 Modification of the Nrf-2 and NFKB signaling pathways by phytochemicals upregulates antioxidant and detoxification enzymes and suppresses inflammation KEAP1 MAF BCL2 PMC3171706__F3 G2/M transition and G2/M checkpoint induction CDC2 ATR C13orf34 WEE1 ATM MDM2 MYT1 PLK1 PMC8250230__F5 An Integrative in silico Drug Repurposing Approach for Identification of Potential Inhibitors of SARS‐CoV‐2 Main Protease CCL3 CFP IL6 CCL2 ACE2 CXCL8 IL1B PMC3171706__F1 G1/S transition and G1/S checkpoint induction CDC6 CDT1 ORC1L MCM7 CDC45 MCM3 CDK2 ATM MCM5 MCM6 MDM2 MCM2 CDK4 PMC2915738__F7 Metalloproteinase-dependent cross-talk between the PDGFRB and the EGFR/ERK1/2 signaling pathway ADAM17 EGFR PMC8346230__F5 Representative diagram of the molecular interactions among AJUBA, CDH4, and CTNNB1 CDH4 AJUBA CTNNB1 PMC8317057__F4 Pathogenic Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Possible Mechanisms for Immune Evasion? STAT3 SP1 TRIM25 TLR3 STAT2 IRF3 CCL2 CCND1 TYK2 NUP98 MYD88 PMC3995130__F2 mTOR Signaling in Cardiac Physiology and Disease RHEB TSC2 TSC1 DEPTOR PMC9050958__F8 Interferon-gamma Induces Melanogenesis Via Post-Translational Regulation of Tyrosinase IFNG STAT1 IFNGR2 MC1R IFNGR1 DCT TYRP1 JAK1 KITLG CTNNB1 PMC3131090__F1 Negative regulation of the autophagy pathway ATG3 ATG12 ULK1 MTOR PMC5139348__F3 PI3K Pathway in B Cell Metabolism SYK HVCN1 BACH2 PTEN PMC5139348__F1 PI3K Pathway in B Cell Metabolism ACLY CD40 TSC2 TSC1 BCR FOXO1 HK2 PTEN PMC5139348__F2 PI3K Pathway in B Cell Metabolism ACLY FAS HEL-S-133P PMC5753586__F2 Non-canonical NFKB pathway in immunity and inflammation NLRP12 TBK1 OTUD7B RELB TRAF3 TNF TRAF2 PMC5753586__F3 Non-canonical NFKB pathway in immunity and inflammation CD40 ICOS BCR GC CXCR5 PMC11871115__F7 Mechanism of action of polyphenols in Alzheimer's disease (AD) through modulation of the WBC signaling pathway DKK1 APC CTNNB1 PMC8360640__F2 Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma STAT3 CXCL12 NGF HGF NGFR ADRB2 MMP9 CXCR4 PMC11695688__F9 Simple signaling pathway diagram ZMAT3 ITGB1 PMC3069928__F1 Biological actions of IGF-1 are mediated by IGF-1R and modulated by IGFBPs IGF1 IGF2 IRS1 PMC2386284__F5 The mechanism of retinoic acid stimulation of NIS expression by modifying signal transduction pathways in breast cancer and thyroid cells, based on the results of the inhibitor studies IGF1 PAX8 RAC1 IRS1 PMC8126715__F1 KRAS-Mutant Non-Small Cell Lung Cancer: An Emerging Promisingly Treatable Subgroup CDC42 STK11 CDK6 ARHA GRB2 MTOR KRAS CDK4 PMC5007117__F2 Schematic representing intrinsic and extrinsic apoptosis initiation BAX MCL1 APAF1 PMC8979796__F4 Metabolic pathways regulating the development and non-genomic heritable traits of germ cells SHMT1 HEL-S-51e PMC8576268__F1 Deciphering glial scar after spinal cord injury USP21 TNF FADD PMC8891573__F1 Dysregulation of the Nitric Oxide/Dimethylarginine Pathway in Hypoxic Pulmonary Vasoconstriction—Molecular Mechanisms and Clinical Significance AGXT2 HEL-S-277 PMC6250734__F8 Diagrammatic sketch of molecular mechanism APC CTNNB1 PMC8102268__F4 Study of the differential expression profiles of Keshan disease lncRNA/mRNA genes based on RNA-seq KLF2 CDR2 FRK SMAD4 ATM PTEN NLK SKP2 INS PMC3938550__F5 Comparative Genomic and Transcriptomic Analyses of LNCaP and C4-2B Prostate Cancer Cell Lines VWF PIK3CD ARHA SRC RELN DOCK1 PMC3407377__F3 TGFB signaling via TAK1 pathway: Role in kidney fibrosis MAP3K7IP1 SMAD2 SMAD4 ATF2 PMC3407377__F2 TGFB signaling via TAK1 pathway: Role in kidney fibrosis MAP3K7IP1 ATF2 TRAF6 PMC6165716__F8 Schematic showing PDK4 as a checkpoint in NFKB/TNF-mediated apoptosis CASP9 PDK4 CASP3 TNF PMC8566352__F2 Plasmalogens and Chronic Inflammatory Diseases AGPS FAR1 HEL-S-5 PMC3912139__F6 GNAS Mutation Found in Pancreatic Intraductal Papillary Mucinous Neoplasms Induces Drastic Alterations of Gene Expression Profiles with Upregulation of Mucin Genes GNAS MUC5AC MUC2 PMC2193446__F7 The hypothesized biochemical pathway responsible for the hyperproliferative phenotype of Nf1 +/− mast cells in response to SCF PAK1 PI3 PMC8514721__F1 Microbiota and Colorectal Cancer: From Gut to Bedside STAT3 IL18 PMC4570227__F4 Metabolic pathways with compounds that can be used as molecular imaging probes for HP MRI FH GLS PC DCT CS HP PMC4498995__F2 Metabolism and transport of acetaminophen in the liver at highly toxic doses UGT1A1 HEL-S-22 CYP1A2 UGT1A3 UGT1A9 CYP2E1 GSTM1 UGT2B15 SULT1A1 SULT2A1 ABCC3 ABCG2 GSTT1 ABCC2 PMC4367189__F2 Signal transduction pathways from the cell membrane to the nucleus discussed in this article FOXH1 SP1 SP3 MTOR RUNX2 SKI PMC6466611__F6 Cyclin C-Cdk8/19/3 inhibit the Notch pathway by phosphorylating the Notch intracellular fragment (NICD) and promoting its degradation in leukemic T cells CDK19 CDK8 CDK3 CCNC PMC4448604__F2 Drosophila Hippo pathway WBP2 ZYX APP SCRIB PMC8443079__F2 Regulation of renin in the collecting ducts AQP2 REN COX2 AVP PMC5289082__F5 Toll-like receptor-mediated actions IRF3 TRAF3 TRAF6 MYD88 PMC7708378__F4 GHR activation and signaling HLA-G LYN IRS1 PMC8021480__F1 Schematics of GSC niches and the redox signaling at play TF GSC FGF2 PMC7969799__F1 The molecular mechanism of TRP channel-mediated pathogenesis of neurological disorders: (A) Alzheimer’s disease, (B) Parkinson’s disease, (C) Huntington’s disease, (D) Amyotrophic lateral sclerosis, and (E) epilepsy TRPM7 CPZ TRPC7 PI3 TRPC4 TRPC1 TRPV1 TRPC5 MTOR BDNF PMC7413060__F1 Innate immunity in the initial phase of infection SIGLEC14 NLRP3 TLR7 IL1B PMC12122306__F1 Insulin signaling pathway in cardiovascular changes in GDM MTOR IRS1 PMC4982242__F1 Non-activated canonical Wnt signaling pathway and the drug targeted components TNKS APC LRP5 LRP6 CTNNB1 PMC4982242__F2 Activated canonical Wnt signaling pathway and the drug targeted components SFRP4 PORCN DKK1 LRP5 LRP6 PMC5662193__F6 Cytotoxic Vibrio T3SS1 Rewires Host Gene Expression to Subvert Cell Death Signaling and Activate Cell Survival Networks SOCS1 JUND PLK2 NR4A3 IL21R PMAIP1 CCL2 CXCL8 NFIL3 BCL2L2 THBD HSPB8 ZFP36 REST CSF2 ID2 PRDM1 FOS BHLHB2 ATF3 CDKN1B IKZF2 TWIST1 KLF4 DUSP10 TNLG5A KLF2 CXCL1 CSF3 INSIG1 KIF1C ZNF100 AMIGO2 F3 CEBPD BMP4 CEBPB RCAN1 JUN EGR1 SGK1 KLF6 LIF SMAD6 CXCL2 PTGS2 IL6 TSC22D3 C2 NFKBIA KLF5 STC1 FGF18 PMC3628101__F1 The novel NRP2A6B1-FAK-RAS-GLI1 axis involved in the regulation of tumour initiating cells in breast cancer BMI1 NRP2 PMC5483433__F2 The potential roles of miR-M4-5p and miR-K12-11 in regulating the TGFB signaling pathway and promoting tumorigenesis LTBP1 TGFB1 DKFZp781O1323 SMAD2 PMC2565686__F6 Merger of the interaction maps for the three human proteins ING1, MEKK, and p38a (p38MAPK) based on empirical data retrieved from the STRING database CD40 ZAP70 BRMS1 GADD45G BUB1B PLA2G1B ATF2 MYC GMFB RB1 STAT1 FYN RBBP4 MAP2K6 CSNK2A2 MRGBP ATF1 HEL-S-1 CREB1 HDAC2 SIN3A SP1 ANXA2 MAPKAPK2 DYRK1B RPS6KA4 DUSP4 MAPKAPK5 PTK2B TNF FOS AXIN1 TRAF1 GRB2 ING1 GADD45A CDC25B MAX CDC42 KRT18 DUSP10 MAPK11 MAPK13 CD36 PCNA PML RUNX2 DUSP2 MEF2C CSNK2B RBBP7 MAP2K4 YWHAQ GADD45B MX1 DUSP16 MAP2K3 HEL2 YWHAG DUSP7 IL1B DIXDC1 MYOD1 JUN GZMA PTPN11 PTPN6 RAC1 GATA3 NCOR2 HDAC1 SAP30 DMAP1 RELA CASP3 DDIT3 CREBBP EP300 YWHAZ PMC8699889__F10 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer ATR BAD PARL MAK ATM CXCR4 PMC11274491__F7 Proposed scheme for the anti-angiogenic activities of PZ-DHA CDC42 CCND3 GSK3B PTEN RHO MTOR PMC8699889__F11 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer CDC2 ATR CDC20 RASSF1 NR3A2 APC IL4 CDK2 ATM PLK1 SKP2 PMC8699889__F12 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer TH SPR BCR LAT HEL-S-11 RHO PMC7197128__F6 FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and Beta-catenin activity in ovarian cancer FAT4 E2F5 CCND1 CTNNB1 PMC7427672__F1 OI genes involved in collagen biosynthesis and maintenance of bone homeostasis PPIB MESD COL1A2 SPARC SP7 IFITM5 P3H1 COL1A1 BMP1 TENT5A TMEM38B CRTAP WNT1 MBTPS2 PAH PLOD2 PMC8125483__F1 Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models IFNG SYK RAF1 NLRP3 IL16 CD82 RELB IL18 CARD9 PMC5680920__F8 Schematic representation of the regulatory mechanism about PLOD2 was summarized FOXA1 EGF TGFA EGFR PLOD2 PMC5010449__F3 Avoidance and subversion of eukaryotic homeostatic autophagy mechanisms by bacterial pathogens ULK1 ATG5 PMC12226309__F1 cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products TBK1 CGAS IRF3 PMC2719424__F8 DUOX1 involvement in TLR-mediated IL-8 production in response to bacterial stimuli TGFA ADAM17 EGFR DUOX1 SRC CXCL8 PMC12226309__F3 cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products CGAS AHR MITA PMC12226309__F4 cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products BAX CGAS NLRP3 IRF3 PMC9163066__F8 Schematic model for the circSCAF8-miR-140-3p/miR-335-LIF pathway STAT3 LIF PMC8395722__F2 Synthetic mRNAs; Their Analogue Caps and Contribution to Disease TSC2 TSC1 BCL2 MDM2 PMC9008121__F2 Targeting non-coding RNAs to overcome cancer therapy resistance COMP AXL AGO2 PTEN SLC7A11 YBX1 CXCL10 PRKDC AURKB ATG2A RAB18 GATA6 TOP2A PMC6351746__F1 Biochemical pathways of R HEL-S-62p MCL1 HAMP PMC8648605__F6 Norcholic Acid Promotes Tumor Progression and Immune Escape by Regulating Farnesoid X Receptor in Hepatocellular Carcinoma RAB27A PMC6476693__F1 Metabolic profiles influence macrophage inflammatory status STAT3 NR1C1 CD36 PMC12118952__F3 LDH in the occurrence and development of liver cancer LDHB PMC7085230__F7 Mechanisms for the inhibition of SMAD2/SMAD3 and the activation of TET1 signaling by MSTN mutation MYOG GDF8 MYF5 SMAD4 PMC5352210__F5 Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism ATF3 EGFR ATF4 PMC7456869__F4 SARS-CoV-2 in the RAAS pathway ATR MRGPRX2 ACE2 PMC7456869__F5 SARS-CoV-2 in the complement system HEL-S-62p C2 C4B_2 PMC8965836__F9 Parathyroid Hormone Promotes Human Umbilical Vein Endothelial Cell Migration and Proliferation Through Orai1-Mediated Calcium Signaling COL1A1 ORAI1 STIM1 NFATC1 PTH PMC7456869__F6 SARS-CoV-2 in coagulation PLG ACE2 PMC3081520__F2 Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease LAMP2 ALG12 ATG14 MTOR ATG5 PMC5653461__F1 Progesterone Receptors (PR) Mediate STAT Actions: PR and Prolactin Receptor Signaling Crosstalk in Breast Cancer Models PRLR WNT1 PMC3081520__F4 Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease ATG12 ATG14 ATG5 FADD PMC8943211__F7 Monoacylglycerol acyltransferase pathway contributes to triacylglycerol synthesis in HepG2 cells LPA TG MGAT2 PMC5041017__F1 IFN signalling pathways induced by IFNA/B and IFNG (see text for details) STAT1 IFNGR2 IFNGR1 STAT2 IFNAR2 IFNAR1 JAK1 TYK2 PMC4915141__F7 The biologic role of TRIM11 in lung cancer PCNA TRIM11 CCND1 PMC5593690__F1 PI3K/Akt pathway: a critical player in intervertebral disc degeneration RHEB BAX BAD GSK3B PTEN DEPTOR CCND1 EIF4E PMC5593690__F2 The PI3K/Akt pathway: a critical player in intervertebral disc degeneration IVD SOX9 GSK3B MTOR CCND1 PMC8620733__F9 CDK4 in the Pathogenesis of Pancreatic Cancer STAT3 CASP9 BAD RAD51 POLK PALM3 BRCA2 JAK1 CDK4 PMC8122967__F1 PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks VEGFC TRADD PARP16 RNF146 MAFG PARG RBL2 PTEN MIF MAPK3 GPX2 BCL2L1 MAP2K6 PDGFRA WEE1 BCL2 GRB2 BIRC2 APAF1 TRAF2 SIRT1 CCND1 FADD BIRC3 PMC8122967__F2 PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks XPA RAD51 FEN1 PARG BRCA2 NOP10 RIF1 SSB XPC DDB2 MRE11A BRCA1 APLF ATM PARP3 POT1 PMC8122967__F3 PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks PARP10 TNKS2 GLS MAFG PARG HEL-S-133P PARP14 HK2 ULK1 FASN PTEN MTOR ME1 PARP1 VHL RHEB TSC2 RICTOR TSC1 TNKS HEL-S-162eP PARP2 HEL-S-26 SIRT1 PMC3057977__F3 Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis CDC2 RCC1 RAN CDC20 APC CS NUMA1 HCTP4 PMC1186689__F1 Interferon-Gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes IFNG COX2 ATF2 JAK1 PMC8620733__F8 CDK4 in the Pathogenesis of Pancreatic Cancer STAG2 DBF4 PCNA STAG1 ORC6 SMC3 GSK3B CD14 SMAD4 SKP2 ORC2 MCM7 CDK7 CDK2 MDM2 FREP1 CD6 PMC7045041__F1 Possible central and peripheral effects of asprosin FBN1 TLR4 AgRP PMC7911844__F2 Biosynthetic pathway of the mcm5s2U modification URM1 PMC4601503__F3 Binding proteins PTEN MTOR PMC2988681__F2 Programming anoikis induction FAS GSK3B SRC FADD PMC6640697__F13 In vivo safety evaluations of MOv18 IgE SYK ITGB1 B2M PTK2B PTPN6 MAPK3 PMC5048206__F2 Schematic depicting the major proinflammatory glial-mediated changes to inhibitory synapses within the spinal dorsal horn that facilitate central sensitization IFNG CCL2 TNF IL1B PMC8053610__F7 The underlying mechanism of calycosin effects on signaling pathways and the induction of apoptosis in GC cells BAD CDK6 CDK2 CDK4 CTNNB1 PMC8092118__F3 5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent MAML1 DLL4 HIF1A MMP9 NOTCH2 NOTCH3 FURIN DLL3 CCND1 RBPJ NOTCH1 PMC8092118__F1 5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent APC LRP5 LRP6 CTNNB1 BMI1 CD44 WLS BCL9 MAP3K7IP1 RNF43 ZNRF3 NLK ABCG2 GPR49 LEF1 CYLD ABCB1 LGR6 PMC2756491__F8 PPARA/p16INK4a Pathway inhibits Vascular Smooth Muscle Cell Proliferation by repressing Cell Cycle-dependent Telomerase Activation NR1C1 CDK6 TERT CDK4 PMC4047132__F2 Cellular functions of proteins commonly mutated in uveal melanoma SF3B1 BRCA1 BAP1 ASXL1 PMC5595793__F1 Schematics of alcohol production via the iterative ketoacid elongation C6 C7 HEL-S-62p PMC4477219__F2 Nrf2/ARE pathway and cAMP second messenger system together are the key regulators of cellular antioxidant defence KEAP1 SIRT1 PMC8586683__F6 Chemokine C‐C motif ligand 21 synergized with programmed death‐ligand 1 blockade restrains tumor growth CCL21 GSK3B CCR7 PMC4073609__F2 By activating Sirt1, NAD+ conjoins two feedback loops necessary for cross-talk between the circadian clock and metabolite production NMNAT1 NAMPT NMNAT2 SIRT1 NMNAT3 PMC9529885__F7 Diesel exhaust particles induce human umbilical vein endothelial cells apoptosis by accumulation of autophagosomes and caspase-8 activation SNAP29 STX7 YKT6 STX17 VAMP8 PMC6850919__F8 Resveratrol (Res)‐mediated suppression of ALI through STAT3/SOCS3 signalling STAT3 SOCS3 SIRT1 PMC9426234__F1 HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways HK3 HK2 PMC8508942__F2 Vascular Smooth Muscle Cell Phenotype Switching in Arteriogenesis KLF4 EGF SMAD2 MRTFB MRTFA MYOCD RHO PMC7076804__F5 Cross-talk between activation of the DDR and the IR upon infection with genotoxin-producing bacteria IL10 IL24 IL13 ATM IL6 IL1B IL9 PMC3080846__F1 Innate Immune Sensing of DNA MAVS TLR9 AIM2 TRAF3 TREX1 CTNNB1 MYD88 PMC8431111__F10 circBTBD7 Promotes Immature Porcine Sertoli Cell Growth through Modulating miR-24-3p/MAPK7 Axis to Inactivate p38 MAPK Signaling Pathway BTBD7 AGO2 MAPK7 PMC3246677__F2 Regulation of viperin expression RIGI MAVS TLR3 TLR4 IRF1 IRF3 IRF7 PMC8904240__F7 Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway PIK3R4 ATG14 BCL2 ATG5 PMC2911411__F3 Network analysis of BAL proteome changes under baseline conditions AFP MYH4 ELANE HBB PMC6603210__F1 IL-1F family signaling complexes IL1R1 IL33 IL36A IL36B IL18BP MYD88 PMC8733588__F2 What Happens to the Immune Microenvironment After PD-1 Inhibitor Therapy? CCL3 CCL2 LAG3 PMC7031046__F6 Identification of cancer driver genes based on nucleotide context STAG2 PIK3CA BCOR SF3B1 ERCC2 EGFR CARD11 BRAF SMAD4 PTEN RHO MTOR SETD2 MYD88 FGFR2 KMT2A POR RB1 CTCF RGS7 CDKN2A FBXW7 MLL2 NRAS ARID2 ATM NF2 POLE HEL-S-26 RPL22 ARHGAP35 ZFHX3 PIM1 APC BAP1 KIT B2M FLG ME1 TNF KRAS VHL HRAS PIR FGFR3 EP300 HLA-A PMC3360100__F3 Examples of signal transduction pathways in astroglial cells following P2Y1R activation STAT3 CASP9 GDNF CASP3 PMC3360100__F2 Examples of signal transduction pathways in astroglial cells following P2X7R activation PANX1 IL16 RHO PMC5125043__F1 The inflammatory response to extracorporeal membrane oxygenation (ECMO) C6 C7 HEL-S-62p C9 IL1B PMC4092924__F2 Schematic illustration of the current working hypothesis on IFNT signaling in ovine uterine stroma and uterine glandular epithelium compared to uterine luminal (LE) and supferficial glandular (sGE) epithelia HEL-S-2 STAT2 IGFBP1 IRF1 B2M SLC7A2 CXCL10 STAT1 AK1 IRF2 ISG15 TYK2 GBP2 PMC4092924__F3 Proposed model of IFNT signal transduction cascades that is independent of STAT1 in the ovine uterine LE and sGE RPS6 HEL-S-2 IRF2 AK1 IRF1 MTOR MAPK3 PMC3495805__F1 Functional roles of pluripotency transcription factors in mesenchymal stem cells BMP4 PMC3133882__F4 Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment LPA APC GSK3B PMC9033251__F1 How compensatory mechanisms and adaptive rewiring have shaped our understanding of therapeutic resistance in cancer EIF4B EGFR MTOR IRS1 EIF4E RHEB TSC2 RICTOR TSC1 CDK6 GRB10 INSR CDK4 PMC11396105__F11 Schematic diagram reveals key genes and pathways involved in the heterosis formation of EFT FAS FGF12 DGAT1 ITGB4 IGFBP4 FOXF2 G0S2 FADS2 SLC27A2 ACACA VEGFA ITGB3 APOF ACACB SLC27A1 IGFBP5 BAAT POMC APOB IGFBP7 MEGF8 SLC27A4 PMC8328821__F3 NUMB/NUMB isoforms in cancer stem cells CDK8 BAD TSC1 ADAM17 JAG2 NUMB PTEN ADAM10 MDM2 GADD45A HES1 PMC8105388__F3 Transcriptome of wild-type and immortalized corneal epithelial cells STAG2 ATR ANAPC13 CDC20 ANAPC7 STAG1 ORC6 SMC3 COCH CDC23 APC SMAD4 SKP2 ORC2 MCM7 CDK7 E2F4 CDC45 MCM3 CDK2 MDM2 PMC11396105__F10 Interaction network of lipid metabolism-associated pathways and key genes PIK3CA DGAT1 CD36 FABP1 MAPK9 ACSS2 ACACB ACOT4 IGFBP5 BAAT DGAT2 POMC ITGA6 IGFBP7 MEGF8 CPT2 PMC4122637__F3 PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics SLC17A1 SLC22A11 LGALS9 SLC17A3 ABCG2 SLC2A9 SLC22A13 SLC22A6 PMC4400837__F2 RAS trafficking pathway CSA2 ICMT RCE1 PMC5872601__F1 The signalling pathways of UPR ATF4 EIF2A XBP1 PMC9255486__F3 Mitochondria: intracellular sentinels of infections BAX CGAS ATF5 MAVS CLPP IRF3 PMC6073339__F2A Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells UCP2 FAS NR1C1 PDK4 CTNNB1 PMC11779860__F6 Mechanistic diagram of HF against HAPH CDK6 PCNA SMAD2 CCND1 PMC5448185__F1 The role of ITSN1 in Reelin signaling in the forebrain DAB1 VLDLR C2 APOE ITSN1 PMC7982600__F1 Known signaling pathways involved in FGF21 expression from skeletal muscle MYOD1 TSC2 FGF21 EIF2A PMC5833071__F7 CXCL12 stimulates expression of connective tissue growth factor CXCL12 CXCR4 RAC1 PMC5114407__F7 Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1 CDK6 CCNE1 CDK2 CCND1 CDK4 PMC6322655__F1 Immune responses of macrophages and dendritic cells regulated by mTOR signaling RHEB TSC2 TSC1 IGF1 PTEN PMC9471422__F2 Contribution of the gut-liver axis to the immune signaling pathway of NAFLD IL10 RAB1A CD14 MYD88 FGF8A PROX1 NR1C1 NLRP3 FOXO1 CYP7A1 TLR4 SIRT1 LBP PMC6885373__F1 DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency GMNN SMARCD3 MYC PMC4865369__F7 Model for wntP-2, ptk7 and ndl-3 in control of patterning ND1 FZD2 FZD7 PTK7 ND3 ND2 FZD1 PMC6073339__F1A Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells KLF2 FAS NR1C1 NR1D1 CPT1C SRC CPT1A CCND1 PMC9368912__F2 Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico PTEN CCND1 AXIN2 CTNNB1 PMC2413267__F1 Wnt Signaling and Skeletal Development APC LRP5 LRP6 CTNNB1 PMC9048904__F6 Thirty years of resistance: Zig-zag through the plant immune system UPF2 FER CAMTA2 CAMTA1 PMC6663587__F7 Signaling cascade in RANKL-RANK induced osteoclastogenesis: A model of IRF8-mediated regulation of osteoclast differentiation DCSTAMP NFATC2 JUNB CTSK OSCAR MAFB NFATC1 IRF8 TRAF6 BCL6 CALCR ACP5 PMC2430594__F1 Cartoon of two of the most promising DNA repair pathways for cancer therapeutics ATR MPG PCNA ATM PMC10921469__F9 TRPM4 and TRPM5 mediate Na+ influx upon stimulation with bitter compounds and carbachol (acetylcholine) in parietal cells from the cell line HGT-1 as major signaling pathway C2 TRPM5 PMC8616751__F2 Therapeutic targeting opportunities in cancer cases with RSPO overactivation RNF43 PORCN APC LRP5 ZNRF3 LRP6 GPR49 LGR6 PMC8616751__F1 Canonical Wnt pathway and the potentiating effect of RSPO JUN RNF43 APC LRP5 ZNRF3 LRP6 GPR49 LGR6 PMC2952500__F1 Schematic diagram showing the results of ras activation by Grb2 EGF PCNA PI3 GATA6 GRB2 PMC6589336__F2 Synthetic Biology Tools for Programming Cell and Tissue TET1 CD19 PMC4232466__F2 Inflammophilic character of the periodontitis-associated microbiota C6 TLR1 SMURF1 MAL ARHA MYD88 PMC4237952__F4 Complement-induced inflammation pathway: an important mediator of neuroinflammatory processes from M4 onwards ITGAM HEL-S-62p C1QC ITGB3 ITGAX C4B_2 PMC4314091__F1 Unusual Case of Porcupine RNF43 APC LRP5 LRP6 TEF CTNNB1 PMC6326012__F1 The metabolic pathway for vitamin D (Adapted/modified from Schlingmann et al CYP2R1 CYP27B1 CYP24A1 PTH FGF23 PMC3574275__F1 Structural and functional characteristics of the human CD38 molecule CD81 TRPM2 BCR CD19 CXCR4 PMC5888214__F4 The SREBP pathway regulates cellular cholesterol metabolism NPC1 HMGCR LDLR INSIG1 PMC9155920__F2 Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling NLRP3 KEAP1 NQO1 MYD88 PMC4841706__F5 Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases CDC2 CCND3 CCNB1 NRF1 CCND1 CDK4 PMC9155920__F3 Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling KEAP1 GSK3B PMC7189101__F10 Proposed model showing the connecting link between AKT and MASTL signaling during mitosis CDC2 ENSA MASTL PMC6372796__F9 Proposed model of IFN and inflammasome activation by HCMV and IL-1B inhibition by IE86 STAT1 CGAS GSDMD STAT2 IFNAR2 IL16 IFNAR1 AIM2 IRF3 MIP PMC9005190__F3 Receptor-specific signaling signatures POR LPA FAS PMC5879765__F4 Osteogenic differentiation through p38 MAPK signaling pathway NPS OSM EBP BMP2 RUNX2 RAC1 PMC8621500__F7 Global Analysis of Transcriptome and Translatome Revealed That Coordinated WNT and FGF Regulate the Carapacial Ridge Development of Chinese Soft-Shell Turtle SOST INVS SIAH1 APC CER1 SKP1 ARHA NLK DAAM1 PMC8627637__F1 Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration FYN KEAP1 GSK3B PMC6513188__F8 Schematic diagram for the inhibitory mechanism of CYC116 in mast cell activation SYK PLCG1 FYN LAT PMC8291708__F1 De novo purine synthesis (DNPS) pathway APRT PAICS ADSL PMC3722362__F3 Regulation of Iron Absorption in Hemoglobinopathies STAT3 CEBPA TFR2 GDF15 SMAD4 EPO HAMP HFE B2M HFE2 PMC4937730__F1 Human polyamine biosynthesis, metabolism and transport and the methionine salvage pathway AMD1 SLC3A2 MTAP SMS SRM PMC5296245__F2 Restoring sAPPA functions as a potential treatment for Alzheimer’s disease BACE1 ADAM10 IGF2 PMC3836673__F1 Intracellular effects of estrogen are exerted through two main pathways, genomic and non-genomic TF SOST SP1 GRB2 SRC PMC9048097__F9 Luteolin attenuates the chemoresistance of osteosarcoma through inhibiting the PTN/Beta-catenin/MDR1 signaling axis by upregulating miR-384 PTN ALK APC GSK3B CTNNB1 PMC3338341__F1 Repressed (left) and activated (right) canonical HH signaling pathways CCND2 GSK3B DHH SHH IHH BCL2 SMO CCND1 GLI3 PMC3338341__F2 Mechanisms of activation of HH signaling in hematological cancers ALK CCND2 GSK3B DHH SHH IHH BCL2 SMO ABCG2 CCND1 PMC3288889__F5 Ephrin-B cleavage and signaling CSK SRC CTNNB1 PMC4026305__F1 Nox NADPH Oxidases and the Endoplasmic Reticulum ATF4 EIF2A XBP1 NOX4 PMC9130907__F1 Hemostasis and tumor immunity TF REN PMC3219632__F11 Suppressor of Cytokine Signalling-6 Promotes Neurite Outgrowth via JAK2/STAT5-Mediated Signalling Pathway, Involving Negative Feedback Inhibition IGF1 SOCS6 PMC12109684__F7 Schematic diagram illustrating the proposed mechanism by which AHE-EA-C exerts its anti-leukemic effects in AML cells BAX CCND1 CDK4 PMC6946788__F2 Decorin and biglycan participate in multiple signaling pathways of innate and adaptive immune responses TGFB1 NLRP3 EPO IL1B MYD88 PMC5489557__F7 Mechanism for PE’s effects on hepatocellular carcinoma cells ATF4 EIF2A PMC6430464__F9 Proposed model depicting the possible mechanism of XIST on mediating cell proliferation, viability and apoptosis via generating a negative feedback regulation of NF‐KB/NLRP3 inflammasome pathway NLRP3 IL1B PMC3255271__F1 Study schema STAT3 STAT1 ABCG2 SET PMC6350112__F1 COMMD7 Regulates NFKB Signaling Pathway in Hepatocellular Carcinoma Stem-like Cells NR2A1 COMMD1 COMMD7 PMC5746469__F3 Initiation of oocyte and follicular growth TSC2 TSC1 EIF4EBP1 RPS6KB1 PI3 PTEN MTOR PMC5994511__F2 Summary of the speculative roles of UNC5C in AD pathogenesis PMC5896264__F1 Central C metabolic network of Brucella (adapted from ) HEL107 RPE HEL-S-162eP MAL TNLG7C CIT PMC8207419__F5 Cytoplasmic‐translocated Ku70 senses intracellular DNA and mediates interferon‐lambda1 induction TBK1 IRF1 IRF3 IRF7 PMC4106657__F4 Cancer driver genes and pathways NTRK1 BRAF CREBBP NTRK3 BCL2 ZNF274 IRS4 PTEN ARHA SH2B1 KRAS OCRL PMC3031497__F7 Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer RPS21 VAPB UBE2C RAE1 TOMM34 PMC9321618__F3 Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms KEAP1 NQO1 PMC5097897__F4 Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling CD44 EGFR CD47 PMC7396672__F6 C1EIP as an activator of ENO1 to promote chicken PGC formation via inhibition of the Notch signaling pathway STAT3 SOX2 ENO1 DAZL PMC4586789__F3 Inhibitors of the Hh signaling pathway target different Hh signaling components SUFU DHH SHH IHH SMO PMC8363310__F3 Expanding TOR Complex 2 Signaling: Emerging Regulators and New Connections LATS1 CD44 MLST8 LATS2 RICTOR SGK1 AMOTL2 PTEN MTOR MYC RAC1 CTNNB1 PMC4647710__F2 Canonical and noncanonical NFKB signaling pathways CD40 LTBR BCR RELA PMC8392837__F1 46,XX DSD: Developmental, Clinical and Genetic Aspects POR HSD3B2 CYP21A2 STAR CYP17A1 CYP11B2 CYP11A1 PMC4502937__F8 Schematic representation of the molecular interactions following macrophage and cancer cell activation TLR4 CCR2 TWIST1 CSF1R PMC7756641__F4 Adaptogens on adaptive stress response intracellular signaling pathways (updated from authors’ drawings) CD14 FOS PMC11682995__F4 Selected signaling pathways regulated by AKR1B10 AKR1B10 KRAS PMC8157222__F1 Lessons from Comparison of Hypoxia Signaling in Plants and Mammals UBR1 RGS4 HIF1A ATE1 VHL PMC8157222__F2 Lessons from Comparison of Hypoxia Signaling in Plants and Mammals VIT RFWD2 ERF UBR1 ATE1 PMC6475831__F2 Regulation of intestinal organoid formation by different growth factors STAT3 EGF WNT3A PMC4159398__F2 Membrane receptors and intracellular signaling pathways activated by IL-4 and/or IL-13 JAK3 JAK1 IL13RA2 PMC8750478__F9 Adipose-Specific PPARA Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue ABCG1 FAS NR1C1 SCARB1 SOAT1 ABCA1 PMC7655096__F2 Major signaling pathways during the process of osteoclast differentiation TEC TREM2 SYK BTK SIRPB1 OSCAR NFATC1 GRB2 PMC6400107__F5A Laser Microdissection-Based Tissue-Specific Transcriptome Analysis Reveals a Novel Regulatory Network of Genes Involved in Heat-Induced Grain Chalk in Rice Endosperm MYB ERF MAK MSC PMC8039187__F7 Findings in the study POLG2 TFAM SSBP1 FH ND6 POLG ND4 ND2 PMC4995293__F5 Extracellular pH‐sensitive ion channels in the PNS KCNQ3 KCNQ2 TRPV1 PMC6580174__F9 Ingenuity Pathway Analysis Molecule Activity Predictor algorithm indicated that loss of nuclear matrix protein 4 (Nmp4) elevates protein folding and attenuates endoplasmic reticulum (ER) stress-induced apoptosis SVIP SEC61A1 UBE4B UGGT1 CANX EDEM1 HEL-S-269 MAN1B1 MAPK8 VCP XBP1 INSIG1 PLAA HEL-S-99n YOD1 PRKCSH DERL1 HSPA2 HEL117 AMFR ATF4 NGLY1 NPLOC4 OS9 HSPA14 SYVN1 SEL1L TRAM1 DDIT3 BCL2 UBXN1 MAP3K5 TRAF2 PMC9675361__F1 DNA repair pathways as a novel therapeutic strategy in esophageal cancer: A review study RAD52 RAD50 RAD51 MRE11A BRCA2 ATM XRCC3 PMC9270569__F1 Cardiovascular Disease in Duchenne Muscular Dystrophy RYR2 PLN MCU PMC5546706__F4 Reconstructing the regulatory circuit of cell fate determination in yeast mating response C6 FAR1 HEL-S-62p C2 PMC8642693__F9 Gentiopicroside promotes the osteogenesis of bone mesenchymal stem cells by modulation of B‐catenin‐BMP2 signalling pathway SMAD1 DKFZp781O1323 BMP2 RUNX2 CTNNB1 PMC9687157__F2 MicroRNAs as Mediators of Adipose Thermogenesis and Potential Therapeutic Targets for Obesity PPARG NR1C1 APPL1 ADIPOR1 ADIPOR2 TLR4 CCR2 CCL2 PMC6056002__F1 Rho GTPase Effectors and NAD Metabolism in Cancer Immune Suppression GSK3B PAK4 NAMPT RHO CTNNB1 PMC5026315__F1 Glomerular basement membrane heparan sulfate in health and disease: a regulator of local complement activation MASP1 C6 C7 MASP2 HEL-S-62p C2 C1S C1R C9 PMC6056002__F2 Rho GTPase Effectors and NAD Metabolism in Cancer Immune Suppression IL10 PAK4 NAMPT RHO RAC1 CTNNB1 PMC9469902__F1 COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy EGFR NRF CCL5 ACE2 PMC9469902__F3 COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy STAT2 IRF9 JAK1 TYK2 PMC9469902__F4 COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy SOCS1 STAT3 SOS1 SOCS3 GRB2 PMC3265021__F2 Signal transduction events that link ER stress to inflammation ELF2 ATF4 TRAF2 PMC8877887__F2 THAB Immunological Pathway as Protective Immune Response against Prion Diseases: An Insight for Prion Infection Therapy IL-21 STAT1 IL10 STAT2 PDC PMC3925795__F1 Simplified schematic of macroautophagy in mammals LRRK2 BNIP3 MTOR PMC7595669__F7 Lipid metabolic pathway analysis of the identified differential lipid species TG FAS PC PMC409892__F2 Apoptotic and antiapoptotic signaling pathways BAD ATM PTEN MDM2 PMC4018400__F4 De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response TBK1 TLR9 TLR5 IRF3 TRAF3 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 FADD PMC6754541__F3 Genome-based metabolic model for cable bacteria with emphasis on electron flow and energy conservation during oxygen and nitrate-dependent sulfide oxidation CYB NONO DCT PMC4018400__F5 De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response ICOS CBL FYN BCL10 LAT C2 CD46 ITK CTLA4 GRB2 LCK CDK4 PMC5341015__F6 Eggshell membrane powder ameliorates intestinal inflammation by facilitating the restitution of epithelial injury and alleviating microbial dysbiosis SDHB ASS1 ASL ALDOB ACO2 HEL-S-162eP OTC ARG1 ENO1 MDH2 PKLR PMC6455062__F3 All currently known proteins required for germling communication and fusion in N CDC42 P1 PMC6176282__F9 KEGG pathway suggested that various targets in p53 signaling were tightly associated with ADQ pharmacological action RFWD2 BAX CASP9 ATR BAD PERP PTEN MYC TSC2 CASP3 CDK2 ATM MDM2 RAX CDK4 PMC3361329__F2 Signaling pathways of TNFAlpha-induced hepatocyte death BAX TRADD ITCH TRAF2 FADD PMC7072595__F3 Multiple mechanisms of SFRP1 involvement in Wnt signaling pathway APC GSK3B SFRP1 CTNNB1 PMC9305838__F3 Dual Function of Par3 in Tumorigenesis LATS1 STAT3 SMURF1 TIAM1 APC SOX2 ARHA RAC1 PMC4113109__F2 Hedgehog signalling at a glance SUFU PTCH1 SMO PMC9305838__F4 Dual Function of Par3 in Tumorigenesis TIAM1 ERBB2 RAC1 PMC10380707__F2 Inflammation, Dopaminergic Brain and Bilirubin UGT1A1 TH HMOX1 CXCL12 COX2 IL13 TLR4 DKFZp666G145 IL6 PMC5502590__F1 Diagram of major TLR pathways MAP3K7IP1 TIRAP IRAK1 TRAF6 IRAK4 MYD88 PMC7193097__F4 Schematic model presents the effect of tea polyphenols (TP) in attenuating STS-induced cytotoxicity in hippocampal neurons BDNF STS PMC9518217__F1 Toll-like receptor (TLRs) agonists and antagonists for COVID-19 treatments TIRAP MAL TLR9 CD14 IRAK2 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TRAK2 TLR7 PMC8889079__F1 NLRP3 Inflammasome in Alzheimer’s Disease and Potential Therapeutic Targets GSDMD NLRP3 MYD88 PMC7787054__F3 Signal transduction pathways regulated by RIT1 CDC42 EGF BAD RGL3 HIF1A RAC1 IFNG NGF RALB RALA IGF1 PAK1 RIT1 GRB2 PMC7834957__F11 lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast-like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR-152-3p SFRP4 APC CCND1 CTNNB1 PMC7862225__F2 Build-UPS and break-downs: metabolism impacts on proteostasis and aging WASHC3 ULK1 HSF1 TFEB EEF2 EIF2A XBP1 PMC8950196__F6 CDH1 Germline Variants in a Tunisian Cohort with Hereditary Diffuse Gastric Carcinoma APC GSK3B CTNNB1 PMC7254133__F7 Model representing the hetIL-15 triggered pathway for tumor infiltration by lymphocytes and dendritic cells CXCL9 IFNG CXCR3 XCR1 XCL1 IRF8 PMC12023894__F3 Natural compounds act on breast cancer (BC) through the Hedgehog (Hh) signaling pathway BAX CTNNB1 CD44 FOXM1 CD24 PTCH1 SHH SMO NOTCH3 CCND1 HES1 NOTCH1 IL1B PMC6379985__F9 Schematic diagram shows the mechanism underlying cTFRC as a ceRNA for miR-107 TFRC MTOR CTNNB1 PMC12023894__F1 Transmission of the classical Hedgehog (Hh) signaling pathway KIF7 PTCH2 SUFU PTCH1 DHH SHH IHH SMO GLI3 PMC12023894__F2 Transmission of the non-classical Hedgehog (Hh) signaling pathway EGF PIK3CA BAD EGFR SMAD2 BRAF SMAD4 PTEN RHO MTOR TGFBR1 CTNNB1 TGFBR2 SHH SMO CCNB1 APC DHH LRP5 IHH LRP6 ARHA KRAS SUFU PTCH1 LEF1 GLI3 PMC5810418__F10 Two B-hyperpaths computed in the full NCI-PID signaling pathway HDAC1 APC GSK3B AXIN1 CTNNB1 PMC4863690__F1 Emerging treatment options for myelofibrosis: focus on pacritinib EPO MTOR JAK1 PMC6484401__F1 Lining up for quality control: linear ubiquitin and proteotoxicity SHARPIN SP1 OTULIN HTT PMC11652534__F3 Annotated map of the target genes related to Beta-sitosterol in VR on RA-related signaling pathways STAT3 SYK KLF2 BAD BNIP3 PTEN CD19 MTOR INS SKP2 RAC1 FOXG1 RHEB TSC2 ATG12 INSR CD37 RXRA CDK2 ATM NLK MDM2 GRB2 PMC7937946__F2 NetworkAnalyst visualization of Reactome pathway “neutrophil degranulation” genes with elevated expression in individuals from Endotype A HEL-S-103 UBC MME RAB7A TUBB4B IQGAP1 ELANE HEL-S-87p PSEN1 S100A9 PMC8465210__F3 Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity SMAD2 SMAD4 PMC9157408__F2 Is there a role for HSF1 in viral infections? HSF1 MTOR PMC11893456__F8 The main pathological changes in COVID-19 brains and related molecular pathways identified CD44 CASP8 CX3CR1 NMNAT1 CX3CL1 SPP1 MPO PMC8268933__F3 Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis BAX CDK6 PLAT CXCR4 CCND1 MMP11 CDK4 PMC3248191__F7 Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors KRT18 FGF8A HMOX1 MAP3K8 FABP5 TNFAIP2 CXCL5 CXCL1 NFKBIZ PMC2966944__F8 Cartoon summary of expression and anatomical data, and a model for phases of A/P axis re-organization WNT1 SFRP1 CTNNB1 PMC6279860__F2 PD-L1/PD-1 signaling pathway and the correlated network TF ZAP70 EGF BATF EGFR LCK PMC10915952__F2 Small molecule compounds inducing the osteogenic differentiation of mesenchymal stem cells SMAD1 DKFZp781O1323 DKK1 APC LRP5 LRP6 RUNX2 CTNNB1 PMC11816792__F3 LncRNAs involved in diabetic foot ulcer healing KLF4 BHLHE23 PAQR3 HDAC8 EZH2 TWIST1 PMC9223893__F1 Gene Expression of the D-Series Resolvin Pathway Predicts Activation of Anti-Tumor Immunity and Clinical Outcomes in Head and Neck Cancer GPR32 GPR18 PTGR1 FPR2 PMC2716493__F1 Two main pathways involved in apoptosis regulation BAD FAS PMC10915952__F3 The crosstalk between the Wnt and bone morphogenetic protein signaling pathways in osteogenesis SMAD1 DKFZp781O1323 APC GSK3B MSC RHO RUNX2 CTNNB1 PMC8938628__SF1 Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting Beta-catenin/TCF4 signaling pathway ABO PMC6279860__F1 Targeted therapy for recurrent/metastatic head and neck cancers STAT3 EGF VEGFC TGFA EGFR APC PTEN MTOR VEGFA TRAF3 CTLA4 RHEB VEGFB TSC2 TSC1 TRAF5 TRAF1 GRB2 SRC TRAF2 PMC11816792__F2 Wounds healing by exosomes derived from adipose stem cells containing lncRNA STAT3 FBN1 SOX9 PAQR3 ULK1 TLR7 DDR2 VEGFA TWIST1 PMC11669685__F6 Schematic summary of the effect and mechanism of baicalin on H2O2-induced oxidative stress, inflammation and apoptosis in BMECs BAX KEAP1 NQO1 PMC12155367__F8 HH signaling pathway functions in the E BAX PCNA CDK2 SMO KIF27 CTNNB1 PMC3193228__F5 Possible mechanisms of involvement of nuclear receptor LRH-1 in development of pancreatic cancer CTNNB1 PMC8452524__F1A Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs TMPRSS2 STAT3 TBK1 MAVS IRAK1 IRF3 IRAK2 IRF7 SOCS3 TRAF3 FURIN TRAF6 IRAK4 NOX4 MYD88 LOX ADAM17 NLRP3 TLR3 TLR8 TLR7 ACE2 PMC1847401__F4 Genes of the insulin/IGF-2 signaling pathway are required for induced stress resistance and induced life extension SGK1 PMC4677197__F1 Canonical Wnt signalling pathway implicated in diabetic nephropathy APC GSK3B CTNNB1 PMC6374915__F1 Different forms of programmed cell death and associated cascades BAX CASP9 CASP8 MLKL TNF FOS RIPK3 ZBP1 NLRP3 CASP5 CASP4 CASP3 RIPK1 APAF1 FADD PMC4684823__F9 Schematic summary depicting fluoride-induced oxidative damage and adaptive response UCP2 ATM SIRT1 PMC7918312__F7 Schematic illustration showing activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway and how PRKAR1B-AS2 regulates it RPS6 TSC2 TSC1 PTEN PMC7379154__F2 Proposed model of skin-associated B cell functions in Alpha-gal sensitization from tick bites IFNG TLR4 CCR6 ELL TLR9 PMC5869742__F7 Inhibitors of prostaglandin synthesis in uterine fluid of pregnant mares HEL-S-22 LTB ALOX5 COX1 PTGR1 ANXA1 PMC9144962__F1 Extracellular Vesicles—A New Potential Player in the Immunology of Renal Cell Carcinoma STAT3 FAS CASP8 CD27 HLA-G TNLG8A SMAD2 CASP3 SMAD4 CA9 PMC3645738__F4 Hypothetical time course of the unfolded protein response in mammals ATF4 EIF2A WFS1 TRAF2 PMC5869742__F5 Involvement of proteins found in the yolk sac fluid and the uterine fluid of pregnant mares in GO terms and pathways representing embryo-maternal interaction RBMX NDRG2 SERPINF2 SOS1 ARPC2 ARPC3 LIPA ACTA2 EZR HSPD1 ADAM17 FLT4 YBX3 COIL SRGN ACTBL2 RPS2 KHSRP MIF VEGFA RPL3 c-fgr FGFR3 ADAM10 LYN CDC37 ACTG2 CDK9 HMGB2 PMC2694616__F1 Genomic Strategy to Elucidate Modules of Oncogenic Pathway Signaling Networks JUN ATM MDM2 MTOR PMC4671004__F1 BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer BAX RICTOR DGKA EGFR MCL1 BCL2 MTOR BAK1 PDE4A EIF4E PMC2696130__F3 Liquid Movement Across the Surface Epithelium of Large Airways ASL CFTR PMC2696130__F4 Liquid Movement Across the Surface Epithelium of Large Airways ASL CFTR PMC3637405__F2 Regulation of the p53-MDM2-MDMX pathway by DUBs USP42 USP4 MDM2 USP29 PMC7552962__F1 Proposed model of interactions between ion channels and Wnt signaling APC CFTR TRPC5 PMC6430251__F1 Schematic diagram to illustrate the activation of the nuclear factorKB (NFKB) pathway in the radiation-induced rescue effect (RIRE) BRCA2 RELA TRAF2 PMC5805701__F10 An atypical IL-6-Stat3-RFX1-IL-17A regulatory pathway in CD4+ T cells of SLE patients ME3 HDAC1 STAT3 RFX1 IL17A PMC7333668__F1 Myosin light-chain phosphatase (MLCP) through regulation of myosin phosphatase target subunit 1 (MYPT1) PPIC HEL-S-28 PAH PMC7694028__F1A BRAF Mutation in Colorectal Cancers: From Prognostic Marker to Targetable Mutation EGF EGFR BRAF PMC7893136__F3 Effect of treatment with EPS L (A,B) or EPS P (B) on apoptotic signaling pathway BCL2L1 IRAK1 RIPK1 TNFSF10 TRAF2 TNFRSF10A IL1B PMC5266718__F8 Schematic model of the S EGF EGFR ARHA PMC8473743__F5 Utilizing Network Pharmacology to Explore the Possible Mechanism of Coptidis Rhizoma in Kawasaki Disease HSP90AB1 NOS2 TBK1 PIK3CA PTGS2 MTOR IRAK4 RAC1 TGFBR2 RELA IKBKB FGFR1 CASP3 FGFR3 PMC3738179__F1 Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling PTCH1 GC SMO PMC6627039__F1 Viral appropriation of cellular nucleocytoplasmic transport NDC1 NUP155 STAT1 NUP153 IRF3 NUP62 NUP98 PMC8452524__F2A Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs TMPRSS2 STAT3 TBK1 MAVS IRF3 IRF7 FURIN MYD88 LOX ADAM17 NLRP3 TLR3 TLR8 TLR7 ACE2 COX11 PMC3837323__F1 PI3K/Akt/mTOR signaling pathway RHEB TSC2 EIF4B BAD TSC1 RAG2 RAG1 ARHA MDM2 SKP2 DEPTOR RAC1 PMC5827530__F7 Gemcitabine/birinapant effects on upstream regulatory proteins HEL-S-22 BAX FAS PYCARD EPHA2 KRT14 FASN PML EVPL DUT KRT4 CKAP2 HMOX1 ADD1 EVL PAWR CRABP2 CLU NOG ABCD3 WAS CCNB1 HCTP4 PPL PMC8010701__F2 Mevalonate pathway SQLE DHCR24 CS MVK HMGCS1 ACAT1 IPP HMGCR ACAT2 PMVK MVD DHCR7 FDPS FDFT1 PMC2781822__F2 Resolution of immune activation defines nonpathogenic SIV infection PDC IRAK1 IRF3 TLR7 MTOR TRAF6 MYD88 PMC5432227__F6 Metabolic heterogeneity signature of primary treatment-naïve prostate cancer PIG59 ALDH18A1 GLS HEL-S-133P PRODH PYCR2 PMC6186045__F5 Regulatory network analysis of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA PRRG4 TYSND1 ANAPC1 PSMF1 PARP12 RNF4 HNRNPK TNF SSB GMPR PMC8010701__F3 Cholesterol homeostatic processes governing the vertebrate retina RPE ACAT1 HMGCR CD36 SQLE DHCR24 LDLR APOB CYP46A1 CYP27A1 ABCA1 MVK PMC3738179__F2 Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling PTCH1 GLA SMO PMC5693733__F3 Melatonin and its metabolites act as radioprotectors on epidermal keratinocytes and melanocytes XPA KEAP1 CPD XPC PMC3675167__F8 Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol NLRC4 NLRP3 IL1B MYD88 PMC4696015__F2 Androgen pathway resistance in prostate cancer and therapeutic implications PTEN MTOR PMC6832561__F3 MRNA-miRNA interactions associated with the vascular endothelial growth factor (VEGF) signaling pathway CASP9 BAD SPHK2 SPHK1 APMAP PRKCA APP PTGS2 SRC PRKCB PMC7260598__F2 ACE/Angiotensin II/AT1R and ACE2/MasR axis TLR4 TLR9 FOXP3 ACE2 PMC3122959__F1 Hedgehog signaling in skin cancers KIF7 BOC SUFU GSK3B BCL2 SMO RAB23 GAS1 PMC6778014__F1 SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION BRAF PMC4009948__F1 Cap-dependent and elongation translational control by GNRH EEF2K EGR1 LHB EEF2 MTOR FSHB EIF4E PMC8463267__AF1 Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NFKB and RAS/RAF/MEK/ERK signaling pathway CDH2 CD44 PMC3757375__F1 Signal Transduction Pathways controlled by the activation of epidermal growth factor receptors (EGFR) EGF HBEGF TGFA EGFR PMC9099445__F1 DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders FUS ATR RAD51 NEIL1 ATM BLM RBM14 PARP1 PMC3206016__F9 Putting into Practice Domain-Linear Motif Interaction Predictions for Exploration of Protein Networks MAGI1 ARHA NET1 PMC7833977__F9 Interferon stimulating genes (ISGs) in the pathway IFNGR2 STAT2 IFNAR2 IRF9 MX1 IRF7 OAS3 ISG15 JAK1 TYK2 CAMK2G PMC4935448__F4 Proposed model of miRNA regulation by simvastation and possible protective role of ubiquinol ABCB11 IRAK1 BCL2 TRAF6 ABCA1 GALNT7 PMC3995058__F4 Mechanism of rejection of MHCIINEG myeloma cells by Id-specific CD4+ T cells CD44 CD40 CXCL9 CD80 CD2 CD27 CD69 APC CCR7 CD200 CXCL10 PMC7826519__F3 Lipid synthetic pathway MLST8 FASN MTOR DEPTOR PMC4836208__F3 Targeting aberrant HH-GLI pathway SUFU SMO PMC9312479__F1 Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis SIRT3 TSC2 PINK1 NLRP3 TXNIP CS MTOR REL PMC4836208__F1 Key components of the mammalian HH signalling pathway HHIP ITCH GSK3B SOX2 NUMB IGFBP6 MEF2C BMI1 FOXM1 SPOP SUFU PDGFRA BCL2 SMO HES1 GLI3 PMC6942366__F8 The role of HULC in hLCSCs ATG3 SIRT1 PMC8629895__F9 Sestrin2 protects against lethal sepsis by suppressing the pyroptosis of dendritic cells GSDMD NLRP3 ATF4 EIF2A SESN2 IL1B PMC7938643__F1 Interplay between the renin-angiotensin-aldosterone system (RAAS) and the bradykinin (BK) system and chymase PLG ACE2 PMC5431483__F1 PI3K/Akt/mTOR signaling pathway and pharmacological compounds used to modulate its activity RHEB TSC1 GSK3B PTEN PMC2571037__F1 Anticancer therapy: boosting the bang of Bim BAD PTEN MTOR PMC9499983__F6 RNA modifications: importance in immune cell biology and related diseases STAT3 TARDBP NSUN2 RRP8 TRMT6 IGF2BP3 JUNB YBX1 YTHDF1 LRPPRC YTHDC1 METTL1 TRMT10C EBI3 WDR4 HSF1 YTHDF2 METTL14 METTL3 IGF2BP2 PMC6316356__F2 Graphic representation of the hepatic Hepc pathway in conditions of systemic iron increase TFR2 HFE TMPRSS6 PMC3307881__F5 Inhibition of the Nedd8 system sensitizes cells to DNA Inter-strand crosslinking agents FANCD2 ATR PCNA ATM PMC11274515__F1 Signaling cascades of autophagy in hepatocellular carcinoma cells (HCCs) ULK1 EGFR PTEN PMC11274515__F3 Various natural compounds (EGCG, emodin, quercetin and crocin) inhibit HCC through interconnected signaling pathways MTOR TNF PMC9237249__F2 COVID-19 Causing ARDS: Exploring the Possibility of Preventing and Treating SARS-CoV-2 FAS TNF ACE2 PMC6625100__F7 Showing Possible effect of the mutation in leptin–leptin receptor signaling pathway STAT3 MOS SOCS3 GRB2 RET PMC5685683__F6 BMAL1 facilitates trophoblast migration and invasion via SP1-DNMT1/DAB2IP pathway in recurrent spontaneous abortion DAB2IP MMP2 MMP9 PMC7389686__F1 Proteins associated with LGMD and other muscle diseases such as DMD POMT2 POMT1 POMGNT2 TRAPPC11 PYROXD1 PMC4450280__F4 Estrogen regulates TNFA NFKB signaling pathway of osteoclasts PSMD3 TNFRSF11A PSMD12 PSMC1 PSMD7 PSMD6 PSMD13 PSMD1 PMC4450280__F5 Estrogen regulates apoptosis signaling pathway of osteoclasts BAX CASP9 JUN FAS CASP8 CASP2 TRADD TRAF3 BIRC5 CASP6 MAP2K4 MAP3K1 CASP4 CASP3 TRAF1 MAPK10 APAF1 TRAF2 CASP10 DIABLO FADD PMC3224136__F7 Schematic pathway showing a possible role for STC2 in affecting the PERK signalling pathway ATF3 STC2 ATF4 EIF2A PMC4450280__F6 Estrogen regulates MAPK signaling pathway of osteoclasts HEL-S-31 CDC42 CASP9 JUN CASP8 CASP2 MAPK8 RAC1 IL1R2 CASP6 MAP2K4 MAP3K1 PAK1 CASP3 MAPK10 PMC4450280__F7 Estrogen regulates cell adhesion and polarization signaling pathway of osteoclasts CDC42 JUN MYL6 ROCK2 ITGB4 ITGB7 CRKL MAPK9 ARHA ITGB3 MAPK8 RAC3 RAC1 ITGB6 CRK ITGB1 ITGB8 RHOB RAPGEF1 ROCK1 RAP1A ITGB5 PMC4791205__F11 YAP Induces High-Grade Serous Carcinoma in Fallopian Tube Secretory Epithelial Cells LATS1 LATS2 FGFR4 FGFR1 FGFR3 FGFR2 PMC4450280__F8 Estrogen regulates Delta-Notch signaling pathway of osteoclasts NCOR2 RELA GSK3B ADAM10 NOTCH2 NOTCH1 PMC4747906__F1 Epidermal growth factor receptor (EGFR) is restricted to the basal surface of the airway epithelial cells EGF EGFR PMC4931665__F1 NFKB signaling consists of two main branches: canonical and non-canonical CD44 CD40 CXCL12 LTBR RELB MMP9 KRAS TNF PMC9405087__F2 Neutrophils and Neutrophil Extracellular Traps in Cardiovascular Disease: An Overview and Potential Therapeutic Approaches VWF HMGB1 PMC5763573__F6 TGF-Beta-induced fibrosis signaling pathway SMAD2 SMAD4 MMP2 MMP9 PMC6789908__F1 Rationale and workflow of CRISPR-BEST PSG5 KY GC PMC5054600__F7 Working model of lifespan extension induced by impt-1 knockdown in C GCN1 ATF5 IMPACT PMC10944225__F8 Schematic summary of the mechanism of the role of BMP2 and the BMPR/Smad1 signaling pathway in the modulation of CGRP expression and progression of BCP SMAD1 BMP2 SMAD4 CALCA PMC2864407__F1 Description of the sex hormone metabolic pathway: genes involved in synthesis, bioactivation, metabolism, and inactivation of estrogen and other hormones SHBG PGR NR3A2 CYP11A1 PMC11817786__F5 Integrative multi-omics data analysis, including DEGs, DEPs, and DElncRNAs TSC2 PYGM SEMA3C ITGB4 LAMB3 PRKCZ INS PMC19384__F10 A model of thymic differentiation CDA IL7R PMC2631307__F1 Glucocorticoids and neonatal brain injury: the hedgehog connection CORT IGF1 SHH SMO PMC4556222__F2 Androgen synthesis pathway HSD17B3 UGT2B15 CYP17A1 CYP11A1 HSD3B1 HSD17B2 AKR1C2 AKR1C1 CYP7B1 PMC5902856__F4 Comparison of phospholipid (PL) synthesis and lipoprotein (LP) formation pathways between 0.16, 2.5 and 10 g salmon PGP CHPT1 CD36 PEMT PRELP PISD PMC9545829__F7 miR‐378a regulates keratinocyte responsiveness to interleukin‐17A in psoriasis IL17RC NFKBIA CEBPB CCL20 PMC7479481__F2 Major signalling pathways of DNA sensors CGAS RIGI DHX36 AIM2 IFI16 IRF3 IRF7 TNF MYD88 PMC6600158__F2 Ubiquitination-monitored regulation of the Wnt/Beta-Catenin pathway in colorectal cancer (CRC) cells SIAH1 TLE3 UBE2O APC UBE2S RNF6 CTNNB1 PMC8504117__F2 Advances in the study of emodin: an update on pharmacological properties and mechanistic basis TBR1 SMAD2 MTA3 SMAD4 SMURF2 HES1 SIRT1 NOTCH1 PMC4890888__F2 EGFR signalling pathway EGF EGFR MTOR PMC6006192__F1 The intramitochondrial iron–sulfur cluster biosynthesis pathway (see text for details) NFU1 SLC25A28 FDXR ISCU BOLA3 LIAS ISCA2 ABCB7 ISCA1 PMC3913761__F2 Emerging roles of store-operated Ca2+ entry through STIM and ORAI proteins in immunity, hemostasis and cancer EGF ORAI3 ORAI1 STIM1 PMC11307123__F6 Mechanism of diabetes promoting myocardial fibrosis via AMP-activated protein kinase (AMPK)/enhancer of zeste homolog 2 (EZH2)/peroxisome proliferator-activated receptor G (PPARG) signaling pathway SUZ12 EED EZH2 PMC10137169__F1 One Carbon Metabolism and S-Adenosylmethionine in Non-Alcoholic Fatty Liver Disease Pathogenesis and Subtypes HEL-S-182mP PEMT CTH PC HEL-S-61p MTR PMC6678221__F1 Role of the canonical Wnt/Beta-catenin pathway in cancer metabolism SCD APC LRP5 LRP6 CTNNB1 PMC6004076__F3 Mitotic errors can trigger activation of p53 LATS2 CASP2 ATM MDM2 PMC9600220__F2 Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions STAT3 IL33 SIGIRR IRAK1 MTOR TRAF6 PIN1 IRAK4 GATA3 MYD88 PMC6167061__F2 (A, B) Intracellular pharmacological chaperoning and matchmaking of G protein-coupled receptors (GPCRs) and downstream effects ATF4 EIF2A XBP1 PMC2696319__F1 Sites of mutation which can result in activation of the Raf>MEK>ERK pathway KIT LYN SRC PMC4720504__F1 Apoptosis pathway: (A) The different paths that a cell can take during the activation of cell death BAX TNF APAF1 FADD PMC9913267__F3 Synthesis and Significance of Arachidonic Acid, a Substrate for Cyclooxygenases, Lipoxygenases, and Cytochrome P450 Pathways in the Tumorigenesis of Glioblastoma Multiforme, Including a Pan-Cancer Comparative Analysis PGC COX1 PTGR1 HEL-S-298 PMC9913267__F4 Synthesis and Significance of Arachidonic Acid, a Substrate for Cyclooxygenases, Lipoxygenases, and Cytochrome P450 Pathways in the Tumorigenesis of Glioblastoma Multiforme, Including a Pan-Cancer Comparative Analysis LTC4S DPEP2 PMC6813721__F7 Inferred role of ACSL1 in sepsis IFNG ACSL1 FACL4 TNF PMC11959162__F2 Phosphorylation in signaling pathways involved in osteoblast differentiation SMAD9 SMAD1 DKFZp781O1323 SOX9 SUFU LRP5 SMAD4 LRP6 SMO RUNX2 CTNNB1 PMC10876676__F2 Upon infection with HIV, the virus infiltrates cluster differentiation positive (CD4+) T-lymphocytes and induce pro-inflammatory intracellular micro-environment marked by increased ILB CRP VCAM1 MPO PMC11959162__F3 Ubiquitination in bone homeostasis and osteoporosis SMAD1 DKFZp781O1323 FBXO31 SMAD2 LRP5 LRP6 RUNX2 SKP2 YAP1 CTNNB1 FGFR2 SMURF1 NEDD4 SMURF2 USP26 PMC3509680__F3 Functional roles of the arenavirus Z protein in the viral life cycle PML IRF3 EIF4E PMC4226683__F6A Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease MMP10 CXCL5 CXCL1 CXCL2 MMP9 IL6 CXCL6 CCL2 CXCL3 CXCR1 MMP3 IL8RB CCL20 IL23A PMC3701121__F3 Angiogenesis signaling pathways in epilepsy CASP9 RHO VEGFA SRC PMC7330666__F2 EGFL6 regulates angiogenesis by activating Akt/ERK signaling EGFL6 GSK3B MTOR PMC9587056__F9 Hypothesis-driven dragging of transcriptomic data to analyze proven targeted pathways in Rhinella arenarum larvae exposed to organophosphorus pesticides HEL126 OAZ1 LOC51064 SMOX AIP PAOX AHRR GPX3 GPX1 FOS DAO GPX8 NFE2 AHR HEL-S-64p PMC7330666__F3 EGFL6 promotes tumor development by activating Wnt/Beta-catenin and Akt/ERK signaling pathways EGFL6 APC GSK3B AXIN1 MTOR LEF1 CTNNB1 PMC4570097__F1 T-MPs function as novel cell-free cancer vaccines CD80 CGAS PMC9066134__F1 Coinfection of fungi with SARS-CoV-2 is a detrimental health risk for COVID-19 patients APC ACE2 PMC3736525__F3 Lycopene induces cell-cycle arrest and apoptosis BAD CDK6 IGBP1 GSK3B IGF1R MDM2 SKP2 IRS1 CDK4 PMC3736525__F4 Lycopene inhibits theWnt/Beta-catenin pathway SP1 IGBP1 APC IGF1R CTNNB1 PMC11882405__F9 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action ATR GPX4 ATM SLC7A11 MDM2 CCND1 CDK4 PMC4278306__F2 SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types SOX17 TEAD2 SOX1 SOX2 SHH HES1 SOX4 CTNNB1 GLI3 PMC7996097__F8 Mechanism of how taurine relieves S ULK1 TLR4 PTEN IL6 MTOR PMC8721187__F3 Insights into the role of paraoxonase 2 in human pathophysiology GSK3B PON2 EIF2A PMC7673844__F1 Sources of serine PHGDH SHMT1 PSAT1 HEL-S-51e PSPH PMC9463538__F12 MAP3K4 promotes fetal and placental growth by controlling the receptor tyrosine kinases IGF1R/IR and Akt signaling pathway HDAC6 PMC4183925__F2 Metabolic pathway of insulin signalling pathway for unigenes by KEGG annotation RHEB TSC2 BAD FAS INSR GRB2 PDK2 MTOR INS EIF4E PMC4939337__F3 Circadian Rhythm Signaling pathway VIP PER3 PER2 SNAP25 AVP PMC2964117__F2 Small-molecule inhibition of the parasite nicotinate mononucleotide adenylyltransferase (NMNAT) NADK CPD PMC4122293__F8 Fibronectin Stimulates Endothelin-1 Synthesis in Rat Hepatic Myofibroblasts via a Src/ERK Regulated Signaling Pathway ARHA GRB2 SRC PMC6662310__F1 Schematic of TriPOINT EMP2 SMAD9 PIK3CA SMAD1 MAPK11 RAF1 MAPK13 PIK3R3 PIK3CD PIK3R1 IGF1R KRAS FGF2 MAPK3 MAPK14 HRAS BMP4 MAPK12 MAP2K1 MAP2K2 IMPACT PMC12026460__F3 Comprehensive mechanism by which Irisin influences fibrosis Via Sirtuin 1 (Sirt1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1A)/nuclear respiratory factor 1 (NRF-1), and related pathways PINK1 SMAD4 NRF1 SIRT1 PMC11314475__F5 Investigating the Molecular Mechanisms of Resveratrol in Treating Cardiometabolic Multimorbidity: A Network Pharmacology and Bioinformatics Approach with Molecular Docking Validation SOCS1 STAT3 CCK OXTR HEL111 FGF7B SOCS2 SOCS3 MAPK8 TCF19 PEX3 ALB MAPK14 HEL-S-99n IFNG KCNA1 KCNB1 VEGFB HTR1B EPOR KL THBD CYGB NRF1 LPL ICAM3 APOE CELSR2 DBH B2M MIF TNF IRS1 TFAM TTF2 SCARB1 HPGD THPO PIGR CALU VEGFC CGAS MAPK11 PGR DHFR TERT RHO MPO THRA PCSK9 FGF7A REN tmp_locus_29 CLU DPP4 SRR SELENOP FGF16 VWF DAG1 PYY KPG_011 ANXA6 FASN CTH SLC22A2 SLC22A1 DPYD CD40LG HDAC1 FGF7 MGP PBR PTGES STAT4 MYOCD MGLL HMOX1 TMEM126A TXN NOX3 KNS2 TPO HDAC2 RYR2 LIMK1 ANXA2 PMP22 PLG FGF10 STRN FMR1 HEL114 CAPNS1 GSTM3 SIGMAR1 PMVK DHCR7 HEL-S-64p HEL107 BMP10 HEL-S-62p GAS INS NOX4 PNP FST ITPR2 DMD MICB OPTN FGF23 JUP CFD ACAD10 DNAAF3 MICA ENPEP HAVCR1 NCOA1 NBEA CILP2 C10orf2 CALCR ADGRL2 GALNT19 TG G6PC1 TMEM216 MGME1 BUD13 HPSE EXOSC10 CPB2 NPC1 EPO AIRE GPX3 HDAC3 CENPO EMD NCOR1 FGFR1 APOL1 UCN GHR RDX MAPK1 CTSK IRF1 AREG NPC2 GFAP GSTM1 MAP3K1 EPHX1 HEL-S-68p ADK HAS1 MAPK7 EDNRB MAP3K7 MAP3K5 NCL DIABLO CA4 FGF12 LEP PCNA FGF21 SPHK1 GPX1 EPCAM AHR KYNU LEPR CFH ANXA1 ENTPD1 HEL-S-162eP XYLT1 BMP2 DKFZp686P11128 MGAM PRSS1 HP ADA RFC4 RFC2 CTSS PPP3CA APLN SRI NBN NAMPT DUOX1 TCF21 DUOX2 ADSL MYOG GPX2 PPT1 ChAT MB HEL113 HGF SLC40A1 EGFR HMMR RARA AGRN RETN SYP BMP4 NR1A2 CRP F13A1 BMP7 UROD HEL-S-130P TFPI PRL HDAC9 PF4 PMC3892938__F2 A schematic representation of IL-12 family cytokines and the corresponding receptors and JAK-STAT signaling pathways IFNG STAT3 STAT1 IL10 EBI3 STAT4 IL23R TYK2 IL12RB1 PMC6338918__F1A Toxicogenomic Approach Reveals a Novel Gene Regulatory Network Active in In Vitro and In Vivo Models of Thyroid Carcinogenesis PRR12 CLEC16A NWD2 ODZ1 HSBP1 SHOX2 RUNX2 HIVEP3 GTF3C6 OSTF1 SLC25A36 PLCL2 CPEB2 APP KIAA1217 TAS1R3 PMC3798724__F2 Wnt signaling pathway in the primary cilia FZD3 APC CTNNB1 PMC3798724__F3 Hedgehog signaling pathway in the primary cilia SPOP SUFU SMO PMC2793049__F2 Leptin signaling and leptin resistance STAT3 TSC2 TSC1 SOCS3 MTOR SH2B1 SRC PMC5341618__F1 Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms NBR1 TBK1 PINK1 FIS1 MAP1LC3A MFN1 BNIP3 FUNDC1 LRPPRC ATG10 USP30 MAP1LC3C ATG12 MFN2 AMBRA1 MUL1 OPTN ATG5 ULK2 BCL2L13 PMC11353125__F1 Receptor tyrosine kinases (RTKs), epidermal growth factor receptor (EGFR), and its variant EGFRvIII activate the PI3K/AKT signaling pathway, subsequently influencing mTOR activity RICTOR ULK1 EGFR PTEN PDK2 PMC10484649__F4 Mitogen-activated protein kinase (MAPK) signal pathway in subchondral bone ATF4 DLX5 RUNX2 PMC2993798__F6 A conserved insulin signaling pathway in C SGK1 INSR PMC8576031__F3 Therapeutic vulnerabilities and regulation of SLFN11-mediated cell death EZH1 IFNG ATR SLFN11 PMC6461634__F5 Proposed de novo synthetic pathway of monorhamnolipids in Pseudomonas guguanensis HEL-S-5 HEL-S-11 PMC3610926__F2 Transcriptional Responses of In Vivo Praziquantel Exposure in Schistosomes Identifies a Functional Role for Calcium Signalling Pathway Member CamKII PLN CAV3 CAV2 BCR MCU PMC3323126__F3 Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus LATS1 CD44 LATS2 EGFR PMC9549209__F7 Carotenoids in orange carrots mitigate non-alcoholic fatty liver disease progression TG ACOX1 CD36 CPT2 PMC3317170__F3 Proposed models for the activation of intracellular TLR9 and TLR3 by Leishmania IFNG TLR3 TLR9 IL6 CCL5 CXCL10 TNF PMC3317170__F1 The activation of TLR2 by Leishmania sp., leading to a proinflammatory (left), or anti-inflammatory arm (centre and right) TH TLR4 SOCS3 MYD88 PMC6087481__F1 Type I IFN-dependent pathway and ER stress response-induced pathway of IFNAR1 degradation IFNAR1 TYK2 PMC3160333__F2 One Carbon Metabolism in SAR11 Pelagic Marine Bacteria HEL-S-61p PMC11882405__F6 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action HEL-S-133P HK2 PTEN PMC7237219__F7 The role of FGF signaling pathway in blood cell migration TTK SULF1 RAC1 PMC6087481__F2 Influenza HA-induced degradation of IFNAR1 blocks the IFNAR signaling pathway STAT1 STAT2 IRF9 IFNAR1 JAK1 TYK2 PMC11882405__F7 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action TBK1 LTBR RELA RELB TRAF5 TRAF3 TNF TRAF2 MYD88 PMC11882405__F8 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action BAD FAS KSR1 GRB2 NR3B3 PMC9200072__F4 Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids STAR SULT2A1 PMC7826839__F1 Role of the adenosinergic pathway in the Glioblastoma microenvironment HEL113 EGFR IL6 CTLA4 TNF CTNNB1 AHR IL2 SIRPA APP GSC FOXP3 LAG3 CCL17 ADA PMC5223135__F4 Proposed mechanisms of kefir peptides-mediated modulation of the lipid metabolism pathway in 30% fructose-induced NAFLD mice STAT3 TG SOCS3 PMC5983871__F11 Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein GBF1 ART1 ACBD3 ARF1 PC GCA PI4KB PMC7785019__F4 Groundwater Elusimicrobia are metabolically diverse compared to gut microbiome Elusimicrobia and some have a novel nitrogenase paralog NAPA IPP NONO HEL-S-5 PMC7167271__F9 PPI plot of IR and fatty acid oxidation MTOR ACACA PHYH PMC5485763__F2 Therapeutic Wound Healing Targets of miR-21Schematic diagram of miR-21 targets TIMP3 and PTEN BAD TIMP3 RAF1 CSK PTEN KDR MTOR PMC8618084__F2 Syngas Fermentation for the Production of Bio-Based Polymers: A Review HBD MTR PMC6696068__F1 Canonical Wnt/Beta-catenin signaling pathway BCL9 BIRC5 TNKS APC GSK3B CCND1 PMC3827157__F4 Transcriptome Analysis of PPARG Target Genes Reveals the Involvement of Lysyl Oxidase in Human Placental Cytotrophoblast Invasion PPARG IGF1R FABP4 ARHGEF3 MGLL INSIG1 HEL-S-99n HMOX1 ACSL1 ANGPTL4 LOX DPP4 ABCG2 GADD45A NR3B3 PMC8391952__F1 Erythropoietin (EPO) as a Key Regulator of Erythropoiesis, Bone Remodeling and Endothelial Transdifferentiation of Multipotent Mesenchymal Stem Cells (MSCs): Implications in Regenerative Medicine EPO RET PMC6613612__F7 Differentially expressed genes in p53 signaling pathway RFWD2 BAX CASP9 ATR FAS SIAH1 AIFM2 PERP PTEN MYC TSC2 SIVA1 CASP3 ATM PIGS MDM2 PMC3946160__F4 Glutamate, BDNF, insulin and glucagon-like peptide 1 (GLP-1) improve neuronal bioenergetics and protect the neurons against neurodegenerative disease and traumatic injury MTOR BDNF FGF2 PMC9355329__F3 Copy Number Variation of Circulating Tumor DNA (ctDNA) Detected Using NIPT in Neoadjuvant Chemotherapy-Treated Ovarian Cancer Patients GSTT2B RHOB CATSPERQ HSF1 NOMO2 ATM OTP PMC3861317__F3 Mechanistic Phenotypes: An Aggregative Phenotyping Strategy to Identify Disease Mechanisms Using GWAS Data FANCD2 ATR BRCA1 BRCA2 ATM FANCA SLX4 PMC5669809__F3 Mixed Chimerism-Based Transplant Tolerance CD40 BAX CD80 APC JAK3 PTEN MTOR PMC3688869__F5 Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer BAX CASP9 DCC BAD MSH2 SMAD2 APC CASP3 PMC4816162__F1 Mitochondria-mediated intrinsic (a) and death receptor-mediated extrinsic (b) pathway BAX TRADD FADD PMC5587377__F2 Tissue Elasticity Bridges Cancer Stem Cells to the Tumor Microenvironment Through microRNAs: Implications for a “Watch-and-Wait” Approach to Cancer BAD VASP BAG1 HEL-S-28 PTEN ARHA SHE PMC8064518__F1 Canonical PI3K-mTOR and GATOR1 signaling pathway and mTORC1-independent pathways RHEB TSC2 TSC1 NPRL2 C16orf35 PTEN DEPDC5 MTOR FLNA FOXG1 PMC8934394__F1 Interaction Between Non-Coding RNAs and Calcium Binding Proteins NLRP3 CAB39 MTOR PMC7483747__F3 IPA TGFB signaling canonical pathway analysis overlaying the WT specific gene list: genes significantly differentially expressed (adjusted p < 0.05) with a |FC|> 2.0 uniquely in WT, E16.5 versus E14.5 BRAF TLX2 GSC PAH NODAL GRB2 RET CP PMC9467392__F7 High expression of CCNB1 driven by ncRNAs is associated with a poor prognosis and tumor immune infiltration in breast cancer MFAP4 PCNA MAL ASPH CYC1 ME1 PMC6326983__F1 Interaction between reprogramming to pluripotency and tumorigenesis BMI1 KLF4 HRAS JDP2 EZH2 HIF1A YY1 PMC4098942__F3 Cancer model pathway HOXB5 EGF FOXB1 LIN7C ECT2 EGFR KSR1 PTPN11 ARHA GRB2 MARK1 PMC3725543__F6 FAK-mediated growth of C2C12 cells in response to IGF-I TSC2 TSC1 IGF1 MTOR PMC3529810__F7 Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response IFNG NEDD8 TLR4 IL6 PMC3706856__F2 The Effect of Curcumin on Breast Cancer Cells BAX PCNA EZH2 CCND1 CTNNB1 PMC3676658__F1 Schematic diagram showing the main components of the TGFB signaling pathway SMAD2 SMAD4 PMC5817364__F2 Polyphenols for the treatment of NAFLD NR1C1 KEAP1 CD36 IRS1 PMC4794511__F3 miRNAs and TGFB signaling pathway IGF1 IGFBP5 SMAD2 PMC2789270__F1 TGFB: A New Role for an Old AktTOR MMP2 MMP9 MTOR PMC3649343__F1 The cholinergic anti-inflammatory pathway depicted APC ChAT TNF PMC7294406__F4 Gene product interaction network of “InterferonG” gene set—an up-regulated pathway in subcutaneous fat of OSA subjects relative to those without OSA IFNG STAT3 STAT1 FAS CASP8 CASP3 TNFSF10 PMC7294406__F6 Cholesterol biosynthesis—a pathway that was up-regulated in OSA subjects treated with CPAP CYP51A1 HMGCR ACAT2 EBP MSMO1 SQLE MVD DHCR7 FDPS HSD17B7 TM7SF2 MVK PMC5590639__F9 Possible interactions between PVN inflammation and sympathoexcitation in spontaneously hypertensive rats HMGB1 TLR4 IGF1R CXCR4 IL1B MYD88 PMC11451039__F2 Modulating mechanisms of the Ang/Tie signaling pathway BAD FOXO1 VCAM1 ARHA SRC RAC1 PMC3131208__F4 NFKB signaling pathways CD40 MAP3K7IP1 LTBR BCL10 BCR RELA RELB TRAF3 TRAF6 TRAF2 PMC3131208__F2 Cellular targets of the Tax viral oncoprotein CDK6 RANBP1 CDK4 PMC7260445__F2 Molecular mechanisms that activate membrane damage C6 RIPK3 GSDMD C7 TRADD MLKL RIPK1 DFNA5 IL1B FADD PMC8868465__F2 Uncoupling Proteins: A Systematic Review on the Mechanism Used in the Prevention of Oxidative Stress UCP2 TRO UCP3 UCP1 PMC8901995__F5 Evaluation of Public–Private Partnership in the Veterinary Domain Using Impact Pathway Methodology: In-depth Case Study in the Poultry Sector in Ethiopia MYOF IMPACT PMC9428719__F7 Metabolic management of microenvironment acidity in glioblastoma OXCT1 ROS1 GOT2 HEL-S-133P PMC7352995__F2 Role of fibroblasts in mammary gland branching and BC growth EGFR PDGFRA SPRY1 FGF2 PMC5785559__F8 Diagram of direct and alternative Runx2-Ihh regulation in chondrogenesis NELL1 IHH RUNX2 RUNX3 PMC7835514__F1 Mouse lung development and early pseudoglandular branching morphogenesis ETV5 HHIP ID2 SOX9 NKX2-1 SOX2 ETV4 SHH FGF10 SCGB1A1 CTNNB1 PMC5530473__F1 Considering the spectrum of colorectal cancer (CRC)—conventional adenomas progress by the sequential accumulation of genetic mutations and chromosomal instability causing microsatellite stable (MSS) tumours PMS1 MSH6 MLH3 MSH2 PMS2 APC BRAF SMAD4 FAP KRAS MGMT CTNNB1 PMC5929452__F3 Non-invasive tumor genotyping using radiogenomic biomarkers, a systematic review and oncology-wide pathway analysis TBX2 STAT3 SKIL PIK3CA RAF1 PIK3R1 EPO ATF2 MYC HSF2 RB1 CCNE1 NF1 FLT4 EPOR OSMR ASCL1 E2F3 PDGFC THBD HEL-S-26 MGMT MAPK1 MMP7 SP1 KDM5B IL7R ANGPT2 RELN RHEB TCF3 IGF1 SOS2 EDNRB BCL2 FGF13 TGFA PGR IGFBP2 SHC2 GNGT2 FOXM1 HIF1AN LPAR4 IFNA17 ETS2 KIT KRAS IGF2 FGF7 MGP PDGFRA NFYA EP300 PTGER4 CA9 CD40 SYK NFATC2 MYBL2 POR MOK NFE2 PIK3C2B PRKCA ADM ERG VEGFA EPHA1 FOS RUNX3 KCNK3 HRAS FOXO1 IGFBP7 LAMA4 IL12RB1 TNC EGF COMP BAD EGFR PTEN CHAD LAMC1 CSF3 ITGAV CTNNB1 RARA CHUK ATF4 GABPA HEL2 RPTOR PDGFD EGR1 E2F2 NGFR NFATC1 GNG3 GNS GNB4 RELA KDF1 GNG11 PMC11702196__F7 Lipid Metabolism Regulatory Network Revealed by Multi-Omics Data Analysis OGA CD40 FAS ARHG MSMO1 CYCS TANK GFPT1 PTEN ABCA1 CYP27B1 SHC4 CHUK APAF1 CREB1 HK2 CD14 PTPN11 CXCL2 TNF KRAS HRAS CRK PRKCI HSPA4 PLCB2 TNFSF10 LBP PMC11702196__F8 Pearson Correlation Network of Lipid Metabolism-Related Molecules in Bovine Hepatic Cells Following TMAO Treatment TH ATF2 PMC8637577__F2 Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance SPNS2 CERK SMS tmp_locus_29 LPP PMC6538961__F7 A Model for cFLIPs-Dependent Lethal Ileitis(A) The complex IIb spontaneously forms in IECs overexpressing cFLIPs RIPK3 MLKL IL16 RIPK1 DUOX2 CCL20 IL1B PMC8534198__F4 Methylosystem for Cancer Sieging Strategy NNMT ALKBH5 WTAP METTL14 YTHDF2 METTL3 PMC7725436__F3 Venn diagram of differentially expressed genes KLF4 STAT3 JUN TGFB1 SP1 HIF1A TNF RUNX2 MYC FOS IGF1 NR3A2 NFKBIA PMC1508148__F1 Pathway diagram of genes tested for association NR1i1 CYP2R1 CYP27B1 IL10 CYP24A1 RXRA GC ADRB2 IL12B SPP1 IL12RB1 PMC3265661__F1 Putative role of the mTOR pathway in pathogenesis and epileptogenesis of focal cortical malformations STRADA RHEB TSC2 TSC1 MTOR EIF4E PMC7979776__F7 Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCA and TSC2-mTOR downregulation HEL-S-72p TSC2 LDB3 BAG3 PC HSPB8 STUB1 PMC5407490__F1 AhR signaling inhibits crosstalk with ERA in breast cancer cells and AhR agonists and antagonists are tumor-specific anticancer agents (24, 25) AHR PMC9496174__F1 Gut Microbiota Regulation of AHR Signaling in Liver Disease AIP AHR AHRR SRC PMC5710702__F1 Three interconnected intracellular signaling pathways in pancreatic B cells VIP CCK GIP PMC11042538__F2 Cellular senescence in cancer: molecular mechanisms and therapeutic targets ME3 ASF1A STAT3 ATR CGAS ATM IRF3 MTOR GATA4 TNF CEBPB HIRA PMC5783597__F7 Schematic diagram of the CCL2/CCR2 axis activating Hh signaling PTCH1 CCR2 SHH SMO CCL2 PMC6684366__F2 Biosynthetic pathway of VLC-PUFAs in the mammalian retina ELOVL4 ELOVL3 ELOVL2 ELOVL1 ELOVL5 PMC8702962__F1 Osteosarcoma and Metastasis FASN MSC CCL5 RUNX2 ID1 PMC6637205__F2 Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis SMAD1 DKFZp781O1323 SP1 FGF21 SMAD2 BMP4 SP3 SMAD4 PMC6637205__F3 Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis MTOR SKP2 DEPTOR PMC8702962__F4 Osteosarcoma and Metastasis IGF1 FGFR1 GSK3B WWOX SPARC CDH4 CXCR4 RUNX2 FGF2 PMC6637205__F4 Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis CDC42 MAP3K7IP1 CD2AP RHO TGFBR1 PMC8568515__F1 MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders ELF2 ATF4 EIF2A XBP1 PMC8428093__F3 Cross talk between gastric cancer stem cells and the immune microenvironment: a tumor-promoting factor CD44 STAT3 CXCL1 MSC SHH GPR49 CTNNB1 PMC10520887__F9 Porcine IKKE is involved in the STING-induced type I IFN antiviral response of the cytosolic DNA signaling pathway TBK1 CGAS IRF3 PMC4236746__F3 Largest key pathway obtained for the colorectal cancer case study MAPK1 CD40 RGS12 JUN EWSR1 CXCL13 GFI1B PIK3R1 EEF1G MAFB NEFL TAF15 NEFH NPY2R CLCA1 NGF CBL SORCS3 IGSF21 ATN1 PMC7223841__F4 NAD+ homeostasis in renal health and disease HEL-S-90n KYNU KMO HAAO AFMID PMC3829926__F1 Phosphatidylinositol 5-phosphate is a second messenger important for cell migration MTMR3 PI3 PIKFYVE PMC4695805__F2 Mitochondrial dysfunction caused by inhibition of pyruvate transfer to mitochondria PDK4 PDK3 PDK2 PMC11922957__F5 Mechanisms of the Draconis Resina on Cardiovascular Diseases STAT3 SMAD2 PLG SMAD4 VCAM1 PTGS2 PIN1 PMC11922957__F3 Multiple Pathways of Draconis Resina Treating MIRI BAX HMGB1 DFNA5 CTNNB1 PMC5874668__F4 Angiotensin peptides are derived from the precursor protein angiotensinogen through several enzymatic conversion pathways ATR HGF ACE2 PMC5788303__F1 Activation of the lipid signaling pathway by GluN1/GluN2A receptor and the creation of transporter mediated drug resistance COX2 ABCG2 PMC11978822__F1 MPDOLs for treating primary lung tumors and brain metastases in NSCLC IGF2BP3 EGFR PMC3944267__F8 Proposed mechanism for the differential response of tenocytes to oxidative stress under different extracellular glucose concentrations SOX9 FOXO1 HIF1A PMC8582496__F4 Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement? SMAD1 DKFZp781O1323 ID1 PMC5099257__F6 Multiple signal transduction pathways and transcriptional networks during cold acclimation in D CBL ICE1 RAB18 PMC6572835__F7 Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma NR2A1 SP1 POFUT1 PMC9399075__F1 Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease CERS3 CERS5 UGCG CERK SMS SPHK2 CERS1 CERS2 SPHK1 KDSR CERS6 PMC9399075__F2 Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease CERS1 CERS2 CERS6 PMC5679454__F4 Tissue force programs cell fate and tumor aggression SCRIB HIF1A RHO PMC9343627__F1 Activation of STING Based on Its Structural Features TBK1 STAT1 CGAS STAT2 IRF9 IRF3 PMC8080439__F1 Antiphospholipid syndrome: Complement activation, complement gene mutations, and therapeutic implications MASP1 FH HEL-S-62p C2 C1S APC C4B_2 PMC5437952__F3 Cholesterol metabolism controls plasmacytoid dendritic cell (PDC) innate functions ABCG1 VLDLR FASN TLR9 LDLR IRF7 TLR7 IL6 TNF ABCA1 PMC4605830__F3 Phosphoproteins down-regulated in PCP and PCPPPI compared to Sal and SalPPI, respectively, which were significantly enriched in LTP signaling pathway GRIN2B CAMK2A PRKCE CREBBP MAP2K1 ARC MAP2 GRIN1 PLCH2 CAMK2G PRKCB FMR1 PMC4961996__F2 Transmembrane signaling by TGFB SMURF1 SMAD2 SMAD4 ARHA MTOR PMC5437952__F2 Metabolic changes in plasmacytoid dendritic cells (PDC) providing energy and affecting their innate immune functions: glycolysis versus fatty acid oxidation coupled with OXPHOS NR1C1 IFNAR2 PDC IFNAR1 TLR9 IRF7 TLR7 HIF1A IL6 TNF PMC8960635__F3 Hyaluronan, a double-edged sword in kidney diseases STAT3 HAS1 HAS3 HAS2 JAK1 PMC7920247__F1 PTEN and PI3K/Akt signaling pathway RHEB EGF TSC2 TSC1 PTEN PMC6433975__F2 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of T cell receptor signaling pathway in asthma CD48 CBL FYN BCL10 LAT ITK CTLA4 GRB2 DAO LCK CDK4 PMC10530615__F1 Starving the Beast: Limiting Coenzyme A Biosynthesis to Prevent Disease and Transmission in Malaria PPCS PPCDC PMC4170638__F6 Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/Beta-catenin signalling in pancreatic adenocarcinoma STAT3 APC GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC7772395__F2 This figure displays a suggested relationship between coagulation and inflammation in patients with a SARS-CoV-2-infection TF TMPRSS2 APC PLG PC IL1A PMC9555118__F3 Periostin: biology and function in cancer EGF BMP1 EGFR APC CTNNB1 PMC5138853__F6 Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway STAT3 IL11 IL11RA PMC7223841__F2 NAD+ homeostasis in renal health and disease NAPRT HEL-S-90n NAMPT NNT PMC8126620__F1 Naturally Occurring Genetic Alterations in Proximal TCR Signaling and Implications for Cancer Immunotherapy ZAP70 FYN LAT VAV1 GRB2 LCK PMC6652073__F6 Proposed models of the CoQ10biosynthetic pathway in mammals showing two alternative sequences of reactions (the decaprenyl chain is abbreviated as R) COQ7 COQ3 COQ2 COQ6 COQ5 PMC7354282__F2 Role of the farnesoid X receptor (FXR) and bile acids NR1H4 APOC2 ATR APOC1 EGFR APC APOE RBP4 APOA2 APOH CLU APOB CP PMC8642280__F4 How alcohol affects insulin‐like growth factor‐1's influences on the onset of puberty: A critical review RHEB TSC2 IGF1 RS1 MTOR IRS1 PMC7818184__F4 VPS4B affects tooth development‐related gene expression through Wnt/B‐catenin pathway APC GSK3B CHMP4B VPS4B CTNNB1 PMC7190874__F10 Liver analysis HEL-S-103 UBC PMC6895966__F4 Functional interactions network analysis of co-occurring mutations in pre-NAC samples CDC42 RFC4 RAN RFC1 SHC1 GSK3B NUMB PPP2CA TGFBR1 RB1 HEL2 HSP90AB1 EZH2 ARHA ERH KRAS RBPJ RAC1 RPA1 HRAS HDAC1 CBL RELA EP300 SNW1 PMC7354282__F4 Renal diseases CRP AHSG HEL-S-92n AMBP APC GC HRG CS HP C4A C4B_2 CP PMC5894800__F1 Enzymes and binding proteins involved in vitamin A and retinoic acid metabolism CYP26B1 LRAT CYP26A1 PMC6708892__F4 The mechanisms involved in the transformation from NSCLC to SCLC RB1 CDK5 MYC PMC6251040__F1 Three modes of programmed cell death BAX FAS IGF1 MLKL MTOR APAF1 PMC4577049__F1 Up-regulation of the inflammatory response biofunction in Rwandan adults during mild malaria compared with day 30 of convalescence SACS ADM KRT16 MAFB JMY C1QB CD40LG MMP9 TBX21 TLR1 SORT1 C1QA FCER1G LILRB4 CLC CLEC2D APOL1 HP LILRA5 LILRB1 IL9 MYBL1 PMC6571119__F3 Possible interactions between ASD causal genes and RA signaling UBE3A FOXN1 RERE NLGN1 RORA PMC3241725__F2 Bacterial manipulation of mitochondrial cell death pathways BAX SDHA CRK CASP9 BAD EGFR CASP3 BNIP3 BCL2 GRB2 PMC8080831__F3 Core components of the Hippo-YAP pathway LATS1 FRMD6 LATS2 WWC1 FAT1 AJUBA NF2 PMC3241725__F3 Bacterial manipulation of host pro-survival pathway CASP3 BNIP3 BCL2 NOD1 PMC6571119__F4 ASD causal genes affecting BMP signaling and potential crosstalk with other signaling pathways UBE3A SHH NLGN3 FMR1 PMC2903433__F4 Chloride Regulation in the Pain Pathway WNK1 WNK4 VAMP2 VAMP3 OSR1 WNK3 PMC11677427__F4 Under physiological conditions, insulin binding to its receptor (IR), which is auto phosphorylated at Tyr residues and consequently promotes the phosphorylation of its substrate, insulin receptor substrate 1 (IRS1), activates the signaling pathway IGF2R IGF1 IQGAP1 IRS1 PMC9379893__F3 Integration of mechanotransduction pathways and innate immune cell activation PIEZO1 EDN1 IL18 MRTFA HEL-S-11 IL6 CCL2 TNF PMC9379893__F1 An overview of mechanotransduction pathways in cells PIEZO1 MRTFA SRC PMC7460590__F2 Overall signaling cascades, including the TGF-beta SMAD cascade (reproduced with permission of Reactome Pathway, Fabregat et al EPO RHO MTOR PMC4861870__F3 Cellular innate response to rotavirus infection STAT1 MAVS TLR3 STAT2 IRF3 IRF7 PMC7460590__F4 TSP-1-CD36 signaling is inducing apoptosis of tumor associated epithelial cells BAX FAS CD36 PMC9673340__F9 N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway IGF2BP1 GEM ALKBH5 CTBP1 PMC6359026__F3 Estrogen signaling pathways in cancer HBEGF EGFR BCL2 GRB2 SRC PMC6947155__F1 Schematic representation summarizing the main extrinsic (cell–cell contact and growth factors) signals that regulate the Hippo-YAP (Yes-associated protein) pathway LATS1 LPA LATS2 EGFR PMC7106920__F1 Relationship between PCOS and immune cells DCT CXCL10 UNK PMC6947155__F2 Hippo Pathway and YAP Signaling Alterations in Squamous Cancer of the Head and Neck LATS1 LATS2 EGFR FAT1 PMC3388731__F5 Canonical Hedgehog signaling PTCH1 SMO MYC CCND1 PMC7072820__F7 MiR-202-5p-mediated SF1 regulation of the canonical TGFB signaling pathway in GCs TGFBR2 SF1 SMAD2 SMAD4 TGFBR1 PMC8837817__F1 Cholinergic anti-inflammatory pathway STAT3 TLR4 CHRNA7 IL1B PMC12124646__F3 Schematic of the mechanism of NMs-mediated SCs in PNR STAT3 GDNF MBP PMP22 MTOR BDNF RAC1 PMC5817803__F2 ALK signaling pathway BAD ALK PTPRB SMO MTOR PMC9170953__F4 Diverse Roles of NETosis in the Pathogenesis of Lupus HMGB1 TLR9 TLR7 PMC7275233__F2 Curcumin-induced apoptotic pathway in human ATR ATM FADD PMC12124646__F5 Mechanisms mediated by NMs that influence macrophage functionality in PNR MRC1 ARG1 MTOR PMC11538887__F8 Mechanism of exosome treatment of androgenetic alopecia PCNA CD200 PMC12027666__F2 S1P-mediated signaling pathways STAT3 S1PR1 SPNS2 S1PR2 SPHK1 RHO SRC S1PR5 S1PR4 PMC11011983__F1 Alterations in Proteostasis Mechanisms in Niemann–Pick Type C Disease GABARAP NPC1 PMC12027666__F1 Sphingolipid synthesis pathways CERK SMS tmp_locus_29 SPHK1 PMC7040395__F7 LGK974 on ccRCC PORCN LRP5 LRP6 CTNNB1 PMC9329277__F4 Integrated genomic sequencing in myeloid blast crisis chronic myeloid leukemia (MBC-CML), identified potentially important findings in the context of leukemogenesis model GATA2 WT1 IKZF1 BRCA2 PHF6 ASXL1 CHEK2 PRPF8 PTPN11 ATM Nbla10317 EZH2 PMC8585665__F1 Major Ca2+-dependent pathways that could be affected by genes mutated in B-cell lymphomas (Table ) SYK CD79B CXCL12 CD79A FAS KLHL6 P2RY8 TLR9 CD22 PTEN MYD88 BTK FZD3 BCR S1PR2 TLR4 BCL2 CXCR4 PMC11788002__F1 Galactose metabolism and proposed pathophysiology HEL-S-19 PMC11851696__F7 Expression profiles of DEGs in pathways related to IAA, GA, and ABA hormones and reactive oxygen species accumulation TF PMC5993623__F2 Recycling endosome and bacterial pathogens CD44 TLR4 MYRIP PMC4849425__F2 Immunomediated Pan-cancer Regulation Networks are Dominant Fingerprints After Treatment of Cell Lines with Demethylation CEBPA HLA-DRA HGF CBLC PMC7653241__F1 S‐adenosylmethionine (SAM) biosynthesis and metabolism PMC4684384__F5 Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages TIRAP CD14 IL1B MYD88 PMC7453842__F1 Schematic depicting pantothenate uptake and transformation into CoA through the CoA biosynthetic pathway PPCS PPCDC PMC9238361__F2 Sirtuin Family and Diabetic Kidney Disease SIRT7 NAPRT SIRT4 SIRT5 SIRT2 SLC7A5 SLC12A8 SLC22A13 SLC5A8 SIRT3 SLC36A4 NADK SIRT1 SIRT6 PMC6128695__F1 Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement EBP NPAS4 ARC BDNF CRTC1 PMC7316886__F3 Dysregulated IFN responses in COPD airway epithelial cells STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 SIRT1 PMC4104445__F1 Life in the bile duct ROBO2 CHST4 CDC20 RNF43 BUB1B CKS2 TLR4 PRC1 TTK SMAD4 IL6 KRAS PMC8226258__F5 X-Inactive-Specific Transcript: Review of Its Functions in the Carcinogenesis KLF4 CD44 TET1 WNT1 ZEB2 MMP9 ABCG2 CTNNB1 PMC6912580__F3 Molecular pathways regarding neuronal survival on which QC seems to assess their effects within the brain NGF MTOR BDNF PMC7316886__F2 Innate immune responses of airway epithelial cells to RV NOS2 TBK1 MAVS CXCL5 CXCL1 CXCL16 IRF1 IRF3 TRAF3 CXCL10 TRAF6 CXCL8 IRAK4 MYD88 PMC6422901__F2 Schematic for arachidonic acid (AA) pathway: phospholipids from the plasma membrane are mobilized and converted to AA by phospholipase A2 (PLA2) enzyme activity LTB COX1 COX2 LTC4S PMC6422901__F3 EP receptors and their downstream signaling: PGE2 binds to its cognate receptors, the E-series of prostaglandin receptors (EP1–EP4) on the plasma membrane and nuclear membrane TF FOXC2 SRC CTNNB1 PMC3132735__F7 CCN2 Is Required for the TGFB Induced Activation of Smad1 - Erk1/2 Signaling Network SMAD1 FLI1 SRC CTGF PMC8914027__F7 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway TBK1 MAVS STAT2 IRF9 TRAF3 TRAF6 MYD88 STAT1 TRIM25 TLR3 IFNAR2 IFNAR1 TLR8 TLR7 JAK1 RHOXF1 TYK2 PMC8914027__F5 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway TBK1 GSTM1 MAVS RRM1 RBCK1 RRM2 IRF3 PPA2 TRAF3 OPTN PMC5736021__F2 PI3K signaling pathway RHEB BAD MDM2 PMC4918391__F2 HVJ-E-mediated cancer cell death.Notes: (A) HVJ-E-mediated apoptosis signaling in cancer cells with CASP8 CASP9 CASP8 MAVS CASP3 IRF3 IRF7 PMC8914027__F6 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway IRF9 IRF1 ILF3 ATF2 JAK1 TYK2 PMC6422901__F4 Combating inflammation promoted by KSHV infection: KSHV infection promotes pro-inflammatory lipid mediators of arachidonic acid pathway and the enzymes involved in their synthesis VEGFC MMP2 VEGFA SRC PMC8914027__F3 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway TBK1 MAVS TRIM25 SFPQ TRAF3 INS PMC8914027__F4 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway TBK1 TLR3 TRAF3 TRAF6 MYD88 PMC9146201__F1 Targeting Energy Metabolism in Cancer Treatment ENO2 HEL-S-68p HK2 HEL-S-162eP PMC2990476__F3 Functional network identified by genes in the single nucleotide polymorphism (SNP) component using independent component analysis PIK3IP1 SLC12A7 PMC8914027__F1 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway TBK1 MAVS STAT2 IRF9 TRAF3 TRAF6 MYD88 STAT1 TRIM25 TLR3 IFNAR2 IFNAR1 TLR8 TLR7 JAK1 TYK2 PMC9560141__F5 Similarities and differences in circadian control of transcript accumulation in key genes involved in primary metabolism and signalling HEL-S-68p HP PMC8438069__F6 Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS H6PD IL6 IL1B PMC7395714__F1 Surface expression of PD-1, PD-L1 and CTLA-4 MGAT1 ARF1 LRBA CMTM6 TOX CMTM4 PMC3180107__F1 Intrinsic and extrinsic pathways of apoptosis CASP9 CASP3 FADD PMC6477581__F1 microRNA-Mediated Tumor–Microbiota Metabolic Interactions in Colorectal Cancer HEL-S-133P FASN MTOR PMC3180107__F2 Molecular mechanism of autophagy and its role in cell death and survival BAD UVRAG MTOR PMC9666758__F3 Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome RASSF6 AMOT FGFR4 NF2 PMC3035032__F3 Simplified schematic illustrating molecular mechanisms of neurite regulation CDC42 STAT3 ARHH COBL FYN PSD PTEN RHO PMC2430620__F1 Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic Signalling Pathways in the Prostate EGF GSTM1 TGFB1 PMC10497558__F3 BCAAs metabolism in Cancer SYK IGF1 USP1 SIRT4 BCAT2 BCAT1 MTOR EIF2A KRAS PMC3143906__F3 Multiple factors and pathways affect insulin-like growth factor 1 (IGF1)-Akt signaling IGF1 HEL-S-28 PTEN TNF PMC10497558__F5 Aspartate, Arginine and Methionine metabolism ASL MTAP OTC ASNS MTR PMC10497558__F6 Aspartate metabolism in solid tumor SLC25A22 SLC1A3 SLC25A13 ZBTB1 ATF4 ASNS KRAS LCK PMC7690754__F17 Pathways involved in BCC pathogenesis LATS1 HEL164 EGF LATS2 HHIP SUFU PTCH1 SMO NOTCH1 PMC10497558__F8 Arginine metabolism in tumor cells STAT3 SLC7A1 ARG1 ARG2 PMC2570554__F4 Anti-apoptotic mechanism of survival and growth of serum-starved 5637 human bladder carcinoma cells HBEGF BAD CBL HGF SRC PMC8290157__F1 RNA Polymerase III, Ageing and Longevity MAF1 POLL POLI MYC PMC4271744__F1 Network analysis of genes significantly modulated in response to mood stabilisers HRAS JUND SP3 GRB2 PMC3762125__F5 Synergy between RasGRP and SOS in TCR signaling PLCG1 LAT GRB2 PMC7918750__F3 Human cytomegalovirus (HCMV) factors that contribute to latency maintenance ACVR1B NAB1 IL6 ARHA CD34 PMC7918750__F4 Human cytomegalovirus (HCMV) microRNA- (miRNA)-mediated reactivation from latency EGR1 EGFR PMC10963930__F0 An active form of vitamin D, calcitriol, directly enhances the expression of Rspo2 by binding to the vitamin D receptor (VDR) NR1i1 MUSK RAPSN LRP4 GPR49 PMC2707261__F1 Regulation of glycolysis, glutaminolysis and de novo nucleotide biosynthesis in tumor cells HEL107 HEL-S-133P SRC PMC7900187__F2 Immune cell amino acid metabolism following mycobacterial infection ASS1 ASL ARG1 ARG2 PMC7999836__F1 Metabolic pathway of PC and TG synthesis LPA TG FAS PC PMC4077819__F5 Inhibition of C3 Convertase Activity by Hepatitis C Virus as an Additional Lesion in the Regulation of Complement Components HEL-S-62p C2 C4B_2 CP PMC9137834__F4 Oxidative Stress in Cancer Immunotherapy: Molecular Mechanisms and Potential Applications STAT3 KEAP1 FGFR1 PTEN MTOR PMC2894844__F7 Schematic drawing of Akt/GSK-3B/tau signaling GSK3B HEL-S-28 PDK2 PMC6895847__F2 The unfolded protein response (UPR) and its connection to cell death ATF4 EIF2A TRAF2 FADD PMC4519949__F2 Proposed effects of salubrinal on the xenotoxicant-activated ER stress signaling pathways ATF4 EIF2A TRAF2 PMC8422786__F2 Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy RNF43 APC ZNRF3 CTNNB1 PMC3226689__F7 Hole-in-One Mutant Phenotypes Link EGFR/ERK Signaling to Epithelial Tissue Repair in Drosophila EGFR HEL70 DDC FOS PMC3428335__F8 Master Regulators in the Metabolic/Transcriptional Coupling in Breast Carcinomas GGPS1 HMGCS1 CYP51A1 HMGCR SQLE PMVK MVD DHCR7 FDPS FDFT1 TM7SF2 MVK PMC2828273__F1 Interconnections between p53 and IGF-1/AKT/mTOR pathways RHEB PTEN MDM2 PDK2 PMC5852411__F2 NHERF1 pathways EGFR CTNNB1 PMC4516163__F1 Numerous arrestin functions play a role in apoptosis and cell survival BAX BAD MDM2 FOS PMC3426219__F2 Chondroitin sulfate proteoglycan 4 (CSPG4) Signaling Pathways HGF MMP2 CSPG4 PMC4809875__F1 Reelin signaling pathway in adult synaptic plasticity DAB1 FYN VLDLR GSK3B MTOR PMC4337036__F2 Schematic overview of intracellular antiviral immune signaling in teleosts TBK1 ADAR TLR3 TLR8 IRF3 IRF7 TLR7 ISG15 MYD88 PMC6572125__F5 Enriched integrin signaling pathway in non-type subtype of bladder carcinoma cell lines CDC42 PXN PARVA EGFR CRKL HEL-S-28 PTEN HEL114 PTER CRK FYN TLN1 GRB2 SRC UNK PMC3098223__F1 Integrative Analysis of Transgenic Alfalfa (Medicago sativa L.) Suggests New Metabolic Control Mechanisms for Monolignol Biosynthesis CAD CCR2 CCR1 PMC9339597__F2 Complement System in Metabolic-Associated Kidney Diseases C6 CD59 C2 C4A PMC6152404__F6 Proposed mechanism for the proliferation inhibitory effects of ART in HCT116 cells ACSL5 FASN ELL PMC9577175__F1 Activation of NOD1 and NOD2 in the development of liver injury and cancer RIPK2 MYSM1 NOD2 NOD1 TRAF6 PMC10158519__F7 Schematic diagram by GroA promotes of expressions of inflammatory mediator TNFA and COX-2 by activating NOD1/RIPK2-mediated JNK, ERK and p38 MAPK pathways in HNSCC progression and metastasis CXCR1 RIPK2 NOD1 IL8RB TNF PMC4622660__F1 Canonical Wnt/Beta-catenin signaling pathway: OFF state COX2 APC LRP5 TANK LRP6 MYC CTNNB1 PMC11899831__F3 Mechanotransduction in tumor cells: sensing and transducing mechanical signals from the ECM into intracellular biochemical signals LATS1 HEL-S-31 LATS2 RCC2 ARHA SRC ARHGAP29 RAC1 PMC7144542__F1 NFKB and MAPK signaling pathway in lumpfish MAX CD40 EGF CXCL12 GEM BPI CD14 BLNK MEF2C CNTF NGF BTK RIGI MOS COX2 RELA HEL-S-69p ATM NLK BDNF IL1B PMC3064559__F3 Interconnectivity of signaling pathways emanating from TLRs and TACI TRAF5 IRAK1 TRAF6 TRAF2 IRAK4 AID MYD88 PMC2846630__F1 Regulation of the mTOR pathway by nutrients (amino acids, glucose), stress and insulin/IGF-1 RHEB GAL RICTOR TSC1 IGF1 HEL-S-162eP PTEN DEPTOR IRS1 PMC3126020__F1 Hedgehog signaling pathway in vertebrates SUFU PTCH1 SMO GLI3 PMC2194118__F6 Molecular dissection of the signaling cascade underlying BCR-controlled integrin A4B1-mediated adhesion SYK BTK BCR PLCG2 BLNK CD19 LYN PMC3126020__F2 Targeting the Hedgehog pathway in cancer SUFU PTCH1 BCL2 SMO PMC3461241__F3 Network analysis suggests an immune response and inflammation in ulcerative tissue and non-ulcerative tissue of patients with ulcerative interstitial cystitis (IC) CD40 SYK HLA-DOB LAT NCF2 TXK HLA-DOA IKBKE GSK3B CTSS MYD88 PLCG1 BTK NRAS ITK MAP2K3 LCP2 NCK1 TICAM2 XCL1 VAV1 IRF7 PTK2B TNF RAC1 CBL IFNAR2 MAPK10 LYN GRB2 PMC4790538__F3 Gene–gene networks generated by pathway analysis.Notes: The networks were generated through the use of QIAGEN’s Ingenuity Pathway Analysis (IPA®, QIAGEN Redwood City, www.qiagen.com/ingenuity) CMC2 MPG PGR MYBL2 TANK SH3RF1 ORC1L CDT1 PPP2R5E KIF23 MMP11 BIRC5 SHCBP1 SEMA6D TUBB2A PRC1 SRC CCNB1 SIPA1L1 UNK BAG1 RRM2 KNTC2 TXNDC11 EPHA4 LMNB2 ORC3 MKI67 GRB7 AURKB CDC45 ERBB2 ETV2 BCL2 CENPA PRSS23 RAB11FIP4 PMC10255416__F7 Supplementation affects metabolic reprogramming of cumulus cells in aging ovarian patients HEL60 FH ENO2 ACO2 HEL-S-133P HK2 LDHB CS SDHA SDHB SUCLA2 HEL-S-32 ENO1 MDH2 HEL-S-26 PMC4917114__F7 An Integrative Transcriptomic Analysis for Identifying Novel Target Genes Corresponding to Severity Spectrum in Spinal Muscular Atrophy BMP4 CNTN1 BCL2 IL6 GATA6 PTGS2 PMC4918724__F5 Integrated microRNA, gene expression and transcription factors signature in papillary thyroid cancer with lymph node metastasis ND4L ND4 COX17 SDHD SDHA SDHB CYB COX2 NDN ND6 NDUFB4 COX3 ND3 NDUFB3 SDHC PMC7443001__F3 Localization of 38 DEGs in the MAPK signaling pathway DUSP10 FAS TRADD ARRB2 GADD45G PDGFA BRAF EVI1 MYC TRAF6 FOS MEF2C IKBKG FGF8A RASA2 NFKB1 FGFR4 CHUK RPS6KA3 GRB2 TRAF2 PMC7443001__F4 Interactions among 38 DEGs involved in the MAPK signaling pathway FAS TRADD ARRB2 GADD45G PDGFA BRAF MYC MEF2C IKBKG RASA2 NFKB1 FGFR4 FGFR1 CHUK RPS6KA3 TRAF2 PMC7607189__F1 miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease AHDC1 SFRP4 BATF NUF2 LAT F3 SAFB RYBP BCL11A FADD PMC6537587__F1 Soluble amylin and pramlintide are capable of activating the endogenous AMYR which is responsible for recruiting adenylate cyclase CAD HEL-S-11 PMC4337782__F1 Manufacturing neurons from human embryonic stem cells: biological and regulatory aspects to develop a safe cellular product for stroke cell therapy EGF LIF SHH PMC182218__F2 Osteoblasts express components necessary for coordinating mineralization of ECM and phosphate handling by the kidney PTH CTNNB1 FGF23 PMC7370084__F3 Four p38 MAPK isoforms are p38A, p38B, p38G, and p38D EEF2 ATF2 PMC9676924__F3 CD160 receptor in CLL: Current state and future avenues STAT3 BAX SYK PTEN PMC7370084__F4 P38 MAPK signaling pathways CD40 EEF2K STAT1 MAP3K7IP1 ATF1 RHO EIF2A MYC TRAF6 TRAF2 RAC1 MYD88 PMC7370084__F1 Summary of the signal transduction pathways through which acupuncture treats nervous system diseases MAX BAX STAT1 BAD TLR4 ATF1 MYC MYD88 PMC8584200__F3 Rho/ROCK Pathway and Noncoding RNAs: Implications in Ischemic Stroke and Spinal Cord Injury BRD4 SEMA3A NRP1 ARHA PMC6334985__F7 Retinal phosphoproteome GNGT1 CNGB3 GPHN FSCN2 AIPL1 CABP4 CPLX4 GPX4 EGFLAM PDE6D PTPRF RP1 RB1 RGS7 HTT BBS2 RHD MYH10 TRPM1 APOE ERC2 PITPNM2 ESRRB CRK ADAM9 PRPF31 RP2 LAMB2 CP XPA HEL-S-62p PRPH2 RHO LAMC1 NDUFS4 GNB1 RBP1 TUB OTX2 GABPA GUCY2D ROM1 BHLHE23 CRB1 GNAT1 CRX USH2A MEF2D RS1 PTPRE RDH12 ABCA4 UNC119 PMC8652208__F3 Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation SOST FGF23 PMC8652208__F2 Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation SOST FGFR4 FGF23 PMC3855681__F4 An Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway CDC42 ZAP70 IL10 JUN LAT GSK3B IL4 RHO CTLA4 IL5 FOS ICOS CBL FYN BCL10 IL2 ITK GRB2 LCK CDK4 PMC10919309__F4 Elucidating the role of Rhodiola rosea L. in sepsis-induced acute lung injury via network pharmacology: emphasis on inflammatory response, oxidative stress, and the PI3K-AKT pathway SYK EIF4B BAD RBL2 PTEN CD19 MTOR MYC RHEB TSC2 BCR RXRA MDM2 GRB2 PMC7210457__F5 BT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex Vivo Anti-sickling Activity in Human Erythroid Cells SYN2 ACCN3 NXN CLSTN2 SHISA2 STC2 TNFRSF25 EPHA4 LAMB1 CD34 STAP2 ADM2 PSAT1 WNT9A TRIM72 NR5A2 SESN2 OTUB2 PMC7555965__F4 Molecular pathways involved in aCML GNB1 TH STAT3 TNK2 SETBP1 MDM2 MTOR SET PMC8196501__F8 Photoactivation of TGFB/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer’s disease model SMAD9 SMAD1 DCX GFAP DKFZp781O1323 SMAD2 SMAD4 PMC10980228__F6 H. Model for the BCM mode of action TEC FES RHO PMC4810618__F7 Selective upregulation of Mcl-1 and HSP27 during HCMV infection of monocytes EGFR MTOR SRC PMC6602950__F6 The rheostat model proposed for Notch signaling network STAT3 EP300 RBPJ PMC8471532__F6 Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients KEAP1 NQO1 MAF PMC8471532__F8 Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients KEAP1 ELF2 ACE2 PMC8471532__F9 Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients LPO MMP9 SIRT1 MPO PMC4460146__F10 The role of Sag in regulation of KrasG12D-induced papillomagenesis ERBIN SAG SKP1 KRAS PMC2724778__F3 Hypothesis-driven two-factor common pathway model path diagram of the metabolic syndrome TG DBP C2 PMC5623081__F7 TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated with Hyperlipidemia SYK TIRAP PLCG2 CD36 IRAK1 SRC TRAF6 IRAK4 MYD88 PMC3973216__F4 Simplified representation of the regulation of actin cytoskeleton pathway and differentially regulated genes CDC42 RGS12 F2R PI3 FGF9 OPN3 ELF3 PMC5355309__F10 25-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis TLR4 GSK3B CH25H PMC8971568__F1 Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus TG HMGCR FASN APOB PMC8899363__F3 Niban apoptosis regulator 1 promotes gemcitabine resistance by activating the focal adhesion kinase signaling pathway in bladder cancer RBM22 DYSF CLTB GPX3 TUBB6 H2AC1 HEL-S-51e SNRPF MRPL13 PPP1R8 RRS1 ITGB6 SNRPE A2M CPSF1 SRC CD163 TUBB4A LIMS1 FBN1 DKC1 WBP11 HRG BOP1 HEL70 FERMT2 ALG5 PPFIBP2 PRCP RBM4 TP63 MCM3 SNTB2 MCM2 LAMA4 TF DPYSL3 TNS1 SNX9 DUSP3 MYLK GATAD2A TFRC FIP1L1 FLAD1 UBAP2L ATM ACP2 ACTN1 BAX CD81 HEL-S-101 MYL6 PARVA CFD IGFALS F13A1 RBP4 SEC61B SBSPON AGR2 WHAMM BYSL MRC1 ELF1 LMCD1 KANK2 TSR1 REL NUP98 PMC4110034__F1 Microbial Egress: A Hitchhiker's Guide to Freedom RIPK3 BAX MLKL CASP3 RIPK1 PMC1775040__F4 WNT Pathways APC GSK3B RHO PMC4561339__F1 Schematic diagram of the protein components involved in the myelin protein-derived inhibition of neurite growth HEL-S-62p LINGO1 ARHA PMC8929360__F3 New insights into the role of melatonin in diabetic cardiomyopathy ATF4 EIF2A SIRT1 PMC7031270__F6 IPA generated networks of transcription factors and differentiation markers BARX2 KRT1 KRT10 JUN FOXN1 PITX1 DSG1 FLG CDKN2B PAX6 IVL FOS DSC1 GRHL1 IRF6 TGM1 FOXQ1 TP63 KLF5 DACH1 CCND1 NOTCH1 ELF3 PMC6179272__F6 Hippo signaling pathway in Duchenne muscular dystrophy LATS1 LATS2 YOD1 ITCH PMC2517590__F2 Schematic overview of the integrin signaling CDC42 CRKL CSK ARHA SRC RAC1 PMC8966131__F4 Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics PTX3 HEL-S-62p CD14 TNF LBP PMC5127598__F5 Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model RFWD2 CASP9 ATR FAS SIAH1 PTEN MYC TSC2 CASP3 CDK2 ATM PIGS MDM2 PMC8821656__F1 Approaches Toward Targeting Matrix Metalloproteases for Prognosis and Therapies in Gynecological Cancer: MicroRNAs as a Molecular Driver AGO4 RAN DGCR8 AGO1 AGO2 DROSHA PMC7443474__F3 Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential TSC2 TSC1 PTEN IGF1R PMC7573103__F3 Signaling pathways in TNBC targeted by multiple components of the MD oils COX2 APC GSK3B LRP5 LRP6 MTOR CCND1 PMC7443474__F2 Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential SOCS1 RNF11 APC GSK3B LRP5 LRP6 IRAK1 TRAF6 CTNNB1 FRAT2 KDM2A RELA ZBTB16 PMC9077270__F8 Alpha-synuclein inhibits Snx3-retromer retrograde trafficking of the conserved membrane-bound proprotein convertase Kex2 in the secretory pathway of Saccharomyces cerevisiae VPS29 VPS35 SNX3 PMC7289845__F1 Prenatal exposure to bisphenol A alters the transcriptome-interactome profiles of genes associated with Alzheimer’s disease in the offspring hippocampus ZNF385A KIF9 TRIM32 SERINC3 ZFHX4 ST7 LRP11 ZNF274 RAMAC CACTIN RBM48 BTK SEPTIN2 MRPL57 RC3H1 JAKMIP2 PHOSPHO2 BNIP2 OLFML3 GPBP1 MAP7D2 EFHC2 CUTC RNF112 PMC11493653__F2 MiRNAs in key phases of diabetic wound healing STAT3 PDGFD PMC7876257__F1 Figure summarizes the potential diet—epigenetic axis in T1DM development FFAR3 MAP2K4 FFAR2 PMC11493653__F3 LncRNAs in main phases of diabetic wound healing STAT3 STAT1 MFGE8 NLRP3 HIF1A VEGFA PMC6402888__F2 Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases FAS TLR4 FABP4 ABCA1 PMC11784099__F9 Antiviral activity of myricetin against pseudorabies virus through regulation of the type I interferon signaling pathway STAT1 CGAS STAT2 IRF9 IRF3 IRF7 ISG15 JAK1 OAS1 PMC9648792__F8 Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer CDC42 BAD CARD11 IL4 CD19 MTOR RHO RAC1 HRAS NGF BCR HEL-S-11 REL PMC3748736__F1 Hippo pathway in Drosophila (a) and mammals (b) FRMD6 CRB1 LATS2 CRB2 CRB3 PCDHJ NF2 AREG DCHS1 PMC3108053__F1 Fanconi anemia pathway and ICL repair: implications for cancer therapy FANCD2 RAD51C ATR ATM FAAP24 FANCL UBE2T PMC3255710__F2 Fine adjustment of autophagy by the AMPK-mTORC1-Ulk1/2 kinase network RHEB TSC2 ULK1 AMBRA1 MTOR ULK2 PMC11550943__F3 Metabolic pathways for a metabolism of glucose via the classical hexosamine pathway has a rate-limiting step at phosphofructose kinase (PFK1) that is inhibited by ATP, low pH and citrate KHK SORD HEL-S-162eP PMC9675801__F1 SPATA2 at the level of TNF-RSC SHARPIN RIPK3 MAP3K7IP1 CASP8 TRADD C2 MLKL RIPK1 TNF CYLD TRAF2 FADD PMC11877844__F6 Possible signaling pathways that are partially stimulated by hCG and induce the synthesis of proteins with cell fusion-activating properties GCM1 SP1 ADIPOR1 MTOR SDC1 S100P TEAD4 CTNNB1 ATF3 INHA TRPV2 HSD11B2 ERVWE1 AKAP12 PMC6142439__F2 Complement-mediated hemolysis in cold agglutinin disease HEL-S-62p C2 PMC6784137__F4 Interactions between autophagy and immunity in response to viral infection ELL MYD88 PMC3472459__F5 Coordinate regulation by NR signaling pathways of genes encoding enzymes in the de novo purine base biosynthesis pathway PPARG PAICS NR2A1 SHMT1 HEL-S-70p ADSL PMC11510019__F3 Illustration of MEHHs’ phenolic acids regulating lipid metabolism pathways ACOX1 FAS CGA HMGCR APOB SIRT1 PMC8190078__F6 RANKL immunisation inhibits prostate cancer metastasis by modulating EMT through a RANKL-dependent pathway GSK3B SRC CTNNB1 PMC11510019__F6 Illustration of MEHH phenolic acids mitigating oxidative stress by modulating various pathways CGA NQO1 HEL-S-5 ATF4 GPX1 PMC5550366__F1 Revisiting the Role of Wnt/Beta-catenin Signaling in Prostate Cancer APC MYC PMC6442983__F7 Proposed model for the induction of the Vps34-autophagy pathway in ETV6 RUNX1-positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells GATA2 CCK GATA1 UVRAG PMC2825293__F2 Nutrient sensing machinery in K- and L-cells GPR119 GIP TAS1R2 PMC9658128__F4 Emerging Effects of IL-33 on COVID-19 PDC IL33 TLR9 IRAK1 IRF7 TLR7 TRAF3 TRAF6 IRAK4 IL1B MYD88 PMC2749258__F3 Approaches to biomarkers in human colorectal cancer ENC1 NRCAM USF2 GSK3B TCF4 CTNNB1 ERBIN FRAT1 MMP26 BMP4 MXI1 MMP7 MSH2 PYGO2 APC LRP5 VEGFA ARHA CD44 TCF7L2 MAP3K7IP1 RUVBL1 RUVBL2 NLK WIF1 PMC11510019__F4 Depiction of how MEHHs phenolic acids regulate the insulin pathway CGA IRS1 PMC11837477__F8 EGFR role in brain development STAT3 EGF HBEGF EGFR SOX2 SHH NUMB PMC9658128__F2 Emerging Effects of IL-33 on COVID-19 CD40 CD80 CXCL1 IL33 CXCL2 MPO PMC11510019__F5 Illustration of MEHHs’ phenolic acids mitigating the inflammatory response by modulating various pathways CGA NLRP3 KEAP1 TXNIP VCAM1 TNF MYD88 PMC11837477__F9 EGFR role in T cell regulation IFNG EGF HBEGF IL33 AREG PMC11837477__F6 EGFR roles in bone development PRG4 HBEGF SMAD1 TGFA EGFR BMP2 IGF1R MTOR PMC11837477__F4 EGFR roles in IECs proliferation and gut regeneration CDC42 STAT3 EREG EGFR AREG JAK1 PMC11837477__F5 EGFR roles in liver regeneration and fibrosis STAT3 HBEGF TGFA ADAM17 CYP7A1 EGFR AREG SRC PMC11837477__F2 EGFR ligands and signaling pathways activation EGF HBEGF CBL EREG TGFA ADAM17 EPGN EGFR BTC AREG SRC PMC11837477__F3 EGFR role in the placenta development STAT3 KISS1 EGF EGFR MMP2 MMP9 ID3 PMC4823347__F5 Molecular signaling partners of ROCK1 LIMK1 ROCK1 ARHA PMC8421605__F4 Effect of Gender to Fat Deposition in Yaks Based on Transcriptomic and Metabolomics Analysis LPL HADHB LEP ACAT2 SCD HACD2 ELOVL6 SLC27A4 HSD17B12 PMC3321152__F4 Non-apoptotic functions of apoptosis-regulatory proteins RIPK3 TRADD RIPK1 FADD PMC4461888__F3 p38 MAPK signaling in osteoclasts STAT1 MAPKAPK2 NFATC1 TRAF6 TRAF2 PMC4665627__F6 Deletion of SPARC Enhances Retinal Vaso-Obliteration in Mouse Model of Oxygen-Induced Retinopathy SPARC FLT1 KDR PMC8963791__F1 Pathways leading to generation of disease biomarkers in NPC NPC2 HEL-S-92n NPC1 PMC4444374__F1A Suppression of Antigen Presentation by IL-10 SOCS1 TBK1 TLR4 IRAK1 IRF3 MYD88 PMC4461888__F1 p38 MAPK signaling in chondrocytes ATF2 BDNF RUNX2 MEF2C PMC4461888__F2 p38 MAPK signaling in osteoblasts CDC42 FGD1 PTH DLX5 RUNX2 PMC4671655__F1 MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells CDC42 YY1 MDM2 PMC5587057__F2 Connectivity analysis of gene products differentially expressed by tissue type and menstrual phase CD3D NCAM2 PCDH10 CD79B RAMP2 KLRB1 PBX1 KRT19 RPS8 CCL23 LGALS2 ITPKA CFI SOX18 KLRD1 KCNG1 STX1A GPM6A SYBU TSPAN7 TRAF3IP3 ZFP69B CCR1 CD6 CCDC68 PGBD5 ZMAT4 RPL12 PDE10A GZMK PKIG TCF21 ARHGEF3 ERG C1QL1 CCL14 SFRP4 APEX1 EDN1 PGR ACACA TNFRSF10A GIPC2 EEF2K GZMH GNLY FCGR3B VWF RAMP3 MAP4K1 PTPRN2 ID1 SFRP1 ID3 ARHGEF18 KLF15 HIF3A IL2RB PRF1 IGFBP5 CALCRL RAMP1 TSPAN12 FBP1 HERC6 ETV7 ZBTB16 CD3G GNG11 LCK PMC5794471__F4 Calcium signaling pathway CAV2 BCR STOM MCU HEL-S-11 DAO PMC5441531__F2 The circadian transcription/translation loop is comprised of rhythmically expressed “clock genes” NPAS2 TTL FBXL3 PMC11208996__F1 Schematic graph illustrating the TGFB/Smad signaling pathway and its roles in the regulation of various biological processes during chronic kidney disease LTB TEC SMAD2 SMAD4 FOXP3 PMC3746560__F7 TG2-containing adhesive/signaling complexes on the cell surface LRP5 LRP6 ARHA SRC CTNNB1 PMC3357465__F1 Gene mutations involved in PTC carcinogenesis NTRK1 BRAF HP GRB2 PMC3653431__F2 Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation STAT3 BMP6 SMAD1 DKFZp781O1323 SMAD4 JAK1 HFE2 PMC8285596__F8 Virilizing doses of testosterone decrease circulating insulin levels and differentially regulate insulin signaling in liver and adipose tissue of females PPARG INSR FOXO1 IRS1 PMC4299585__F10 Mechanisms underlining the sphingosine-1-phosphate (S1P)/sphingosine kinase 1 (SphK1)/S1P receptor (S1PR) 2 signaling axis in pulmonary arterial hypertension (PAH) STAT3 SPNS2 S1PR2 SPHK1 PAH PMC9289270__F1 LncRNA, an Emerging Approach for Neurological Diseases Treatment by Regulating Microglia Polarization IL13 TLR4 MYH9 CH25H CXCR5 TLR7 MYD88 PMC9289270__F2 LncRNA, an Emerging Approach for Neurological Diseases Treatment by Regulating Microglia Polarization HDAC1 STAT3 NLRP3 IL18 TUG1 NOTCH1 PMC7261723__F8 Proposed model for the role of Isc1 and Cdc55 in the HU-induced signaling pathway CIB2 CDC20 APC INCENP PC NET1 PMC12192587__F5 Predicted Regulatory Networks Influencing Muscle Fiber Type Transition by ECM Coatings MYOD1 DDR1 FOXO1 NFKB1 SRC MEF2C MEF2D PMC8584317__F3 Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis TSC1 MTOR EIF4E PMC2975074__F3 Cell stress response: activation of the aggresome pathway, HSPs, and transcriptional response HSF1 VCP HDAC6 PMC8584317__F1 Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis SOST APC GSK3B LRP5 LRP6 RUNX2 CTNNB1 PMC2724661__F1 Complement system in AD CD59 C7 HEL-S-62p C9 PMC8584317__F4 Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis BAX BMP2 SHH IHH SMO RUNX2 PMC8960266__F1 Imaging Sub-Cellular Methionine and Insulin Interplay in Triple Negative Breast Cancer Lipid Droplet Metabolism TSC2 PMC8623546__F11 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease NEK8 ATR ATRIP RAD51 PMC8301100__F1 Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease RBX1 PINK1 KEAP1 NQO1 GSK3B PMC4503872__F3 Results from a transcriptomic analysis of the OCM: Downregulated genes were, dependening on their level colored in green, upregulated in red MTHFD1 DHFR SHMT1 TYMS MTR HEL-S-51e AHCYL1 PMC8301100__F2 Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease PINK1 FYN GSK3B PMC8623546__F10 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease TF LAT RHO LAT2 PMC12071115__F2 Relationship between the regulation of TFPI2 expression in cancer cells and host cells EGF TGFBI HGF TIRAP ACTN4 MYH9 TMPRSS4 MBD3 PSAP CCND1 PMC10882314__F2 Emerging role of SENP1 in tumorigenesis and cancer therapy STAT3 BAX GATA1 HK2 HIF1A MMP9 MYC UBE2T SIRT3 SENP1 FGFR1 MMP2 METTL3 PMC4824625__F3 A-to-I editing of coding and non-coding RNAs by ADARs ADAR ENDOV MAVS IRF3 SUV39H1 PMC7926383__F6 Genes of the VEGF-C/VEGFR-3 signaling pathway known to be involved in hereditary lymphedema VEGFC FLT4 ADAMTS3 PLG FURIN PMC4824625__F4 A-to-I editing of coding and non-coding RNAs by ADARs ADAR DROSHA PMC4495933__F3 Secreted Frizzled-related proteins (sFrps) BMP1 WNT3A PMC8357839__F6 Ketogenesis controls mitochondrial gene expression and rescues mitochondrial bioenergetics after cervical spinal cord injury in rats TFAM STAT3 KEAP1 MAL PMC4495933__F2 Roles of Wnt/Beta-catenin signaling during vertebrate heart development MESP1 DKK1 CTNNB1 PMC3104011__F2 miRNAs regulate DSB DDR through modulating the core protein components of various pathways CDC2 BAX ATR RAD50 FAS RAD51 BRCA2 PLK1 MDC1 RAD51B RAD51C MRE11A BRCA1 RNF168 CDK2 MDM2 PMC8416736__F2 Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations ADAM10 VCAM1 IL1B PMC6051890__F32 The diphthamide biosynthetic pathway and the mechanism of diphtheria toxicity DPH1 DPH2 DPH3 DPH5 PMC7155771__F2 The amino acid modulator arm of the mammalian target of rapamycin (mTOR) pathway RHEB TSC2 TSC1 TBC1D7 MTOR SLC38A9 PMC4403556__F1 miR-137 Intersection Target Network of Neurological Disease DUSP5 KLF4 CDC42 TARDBP CACNA1C PTPN5 SGTB GNAT1 TJP1 SERPINA3 COCH TFAP2A KIT PTGS2 FOXN3 SLC12A2 RB1 NF1 NAB2 CDK2 SRC NOTCH1 MBD2 HTT PMC7729087__F4 Aminoacyl-tRNA synthetases and potential therapeutic applications FAS CDH6 AIMP2 MSC PMC3344687__F7 Schematic diagram of the Heme/TLR4/MyD88 and/or TRIF hypothesis in ICH TLR4 IRF3 MYD88 PMC4403556__F2 miR-137 targets within Protein Kinase A (PKA) Signaling Pathway MAPK1 PLN DCC BAD VASP NGFR SMAD4 TCF4 PTGS2 ARHA MAPK3 EBI3 SMO ATE1 CREB1 GLI3 PMC2972700__F1 Wnt Signaling During Fracture Repair DKK1 APC ROR2 LRP5 RYK SRC LEF1 SFRP1 CTNNB1 PMC5426069__F6 Analogue signalling pathway of TXNIP mediated by ER stress may be a novel therapeutic target in SAH-related EBI ATF5 NLRP3 TXNIP EIF2A PMC3502657__F2 Signaling pathways for longevity KRI1 PTEN CCM1 TCERG1 PMC8713066__F1 Gut microbiota and probiotics on Alzheimer’s disease TIRAP TLR4 CD14 MYD88 PMC3502657__F1 Signaling pathways for longevity RHEB RICTOR IGF1 SGK1 PTEN PMC8861075__F1 Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease HEL-S-90n IDO1 KMO IDO2 PMC12250041__F1 Experimental Models and Their Applicability in Inflammation Studies: Rodents, Fish, and Nematodes STAT1 TLR3 TLR4 MYD88 PMC5470738__F1 Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgRKT to the List LPA PLGRKT APOE LDLR EPO AAAS PMC11040350__F1 Platelet Membrane Nanocarriers Cascade Targeting Delivery System to Improve Myocardial Remodeling Post Myocardial Ischemia–Reperfusion Injury STAT3 IL19 ARG1 TNF PMC8629847__F1 MyD88 Signaling Leads to Cell Specific Functions in Cardiovascular Disease HMGB1 IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 IL1B MYD88 PMC12071115__F5 TFPI2 in pregnancy-induced hypertension, diabetes, and atherosclerosis EZH1 TNF PMC6299090__F7 miR-100 maintains phenotype of tumor-associated macrophages by targeting mTOR to promote tumor metastasis via Stat5a/IL-1ra pathway in mouse breast cancer MTOR GLI3 PMC3501616__F4 Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome wide association on chromosome 1p22 IRF6 TP63 TFAP2A ARHA ARHGAP29 PMC9626853__F1 Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery MASP1 C6 C7 HEL-S-62p C2 C1S C4A C4B_2 PMC6653007__F1 Ferroptosis induction STAT3 SLC3A2 ACSF2 CHAC1 GPX4 SLC7A11 ATF4 CS PMC6524515__F1 ADAM17/TACE: a key molecule in brain injury regeneration TGFA ADAM17 EGFR PMC8992442__F2 Targeting of PI3K/AKT signaling and DNA damage response in acute myeloid leukemia: a novel therapeutic strategy to boost chemotherapy response and overcome resistance ASXL1 ATM KRAS PMC6602878__F3 GDNF expression in Sertoli cells JAG2 NOTCH2 NOTCH3 RBPJ NOTCH1 PMC7324848__F10 P-TEFb complex activation following activation of the A1-AR or ETR TF BRD4 AFF4 CDK9 PMC7226606__F1 Metabolic reprogramming in cancer cells ACLY SIRT3 EGF HEL-S-133P PTEN ENO1 MDM2 SRC PMC9106060__F4 Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2A and AP-2G Transcription Factors in Bladder Cancer CDC42 CRK FAS PKD1 CAD RAD1 HEL-S-62p LAT GIP RHO DAO OTP PMC4845654__F4 Beyond Beta-catenin: prospects for a larger catenin network in the nucleus REST APC GSK3B LRP5 LRP6 CTNNB1 PMC8548824__F3 Cabozantinib for HCC Treatment, From Clinical Back to Experimental Models FLT3 AXL MTOR RET PMC10969083__F6 Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways GNAI3 CD3D PIK3CA PLCB4 FAS TGFBI HEL-S-62p AKT3 SMAD2 PPP2CA MAPK9 TRAF6 IRAK4 IKBKG TGFBR1 MYD88 TGFBR2 GNAS HEL-S-99n IFNG IFNGR2 MAP2K4 PPP2R2B CHUK PLCB3 GNAI1 NOS2 JUN IFNGR1 CASP8 IL6 TNF FOS GNA15 PPP2R2A RELA IKBKB PPP2R2D CD3E BDKRB2 FADD PMC10969083__F7 Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways COX7B NDUFB8 NDUFB6 NDUFB2 NDUFB5 NDUFB11 PPIF NDUFA9 NDUFB9 NDUFS5 NDUFA6 COX7C NDUFA7 NDUFS8 PDK2 NDUFA13 COX6A2 NDUFS3 NDUFA11 NDUFS4 COXFA4 NDUFB4 NDUFS6 NDUFA3 NDUFB7 NDUFB3 CPT2 NDUFC1 COX6B2 NDUFC2 ATP5PB MPC1 PDK3 MPC2 SDHD SDHA SDHB PDK4 ATP8 NDUFA2 NDUFS1 COX6B1 NDUFA5 PMC8426249__F1 Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse GBP3 TBK1 CGAS MAVS STAT2 IFIT1 IFIT3 IFIH1 IRF7 IL6 TFAM STAT1 IFNAR2 IFNAR1 IL18 CLPP IFNB1 ISG15 IFNA1 EIF2AK2 IL1B PMC10969083__F4 Regulated genes in the Adrenergic signaling in cardiomyocyte KEGG-constructed pathway PLN POPDC2 MYB ATP2B1 PLCB4 PIK3R5 CACNA2D2 MYH6 AKT3 ATP2A2 PPP2CA PPP2R5C PPP2R3C GNAS CAMK2A PPP2R2B MYH7 MYL2 TNNI3 HEL-S-108 CACNA2D3 ATF4 CACNB3 PPP2R5D CALML3 RYR2 SLC8A2 ATP2B2 PPP2R5B RAPGEF4 POPDC1 PPP2R2A ADRB2 CALM1 PPP2R3A BCL2 PLCB2 CACNB4 PPP2R2D RPS6KA5 SCN4B PPP2R5A PMC10969083__F5 Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways PLN MYB TGFBI HEL-S-273 MYH6 CACNG8 ATP2A2 ATP2A1 GNAS TPM1 EMD tmp_locus_29 MYH7 TPM3 TTN TNNI3 CACNA2D3 DMD CACNB3 MYBPC3 RYR2 SLC8A2 CACNG2 TNF CACNA2D1 ADRB1 CACNB4 PS1TP5BP1 LMNA PMC2173020__F1 Cross-talk between growth factors and integrins in endothelial cells BAX SYK SRC PMC4671844__F1 Molecular pathways leading to CRC MSH6 MSH2 PMS2 APC BRAF KRAS PMC4671844__F2 MAPK signaling pathway in CRC EGFR GRB2 MTOR PMC6292222__F3 T cell differentiation IL2RB APC CCR7 PMC4428545__F2 Ratio heatmaps of identified canonical TCR signaling proteins that showed significant changes of phosphopeptide abundance for both types of stimulation (q value < 0.05; > 2–fold or < 0.5-fold) ITK GRB2 PMC8261186__F3 Vitamin D Toxicity Managed with Peritoneal Dialysis CYP2R1 CYP27B1 CYP24A1 PTH FGF23 PMC3228973__F4 Proposed signal transduction pathways in nodose ganglia following receptor activation with leptin and cholecystokinin-8 (CCK-8) CCKAR ARHA SRC PMC5019079__F3 Hypothetical scheme of production and effects of oxidized fatty acids TES LOX RXRA PAH PMC6538889__F1 Switch-on and switch-off of canonical and noncanonical Wnt signal pathway JUN APC LRP5 LRP6 RAC1 CTNNB1 PMC8639147__F10 Mechanistic model of REST-dependent homeostatic rearrangement of inhibitory inputs in response to hyperactivity REST SLC32A1 GAD1 NPAS4 PMC2938150__F3 Comparison of fluxes of central carbon metabolism determined by MFA and predicted from a genome-scale metabolic model TK1 HEL-S-162eP CS PMC8136750__F2 NAD Metabolism and its biological role in mammalian cells NRK NAMPT PMC4399270__F4 Functions of Klotho CYP27B1 FOXO4 FOXO1 ADA PMC7645048__F7 LINC02381 effect on Wnt signaling pathway APC CTNNB1 PMC3004524__F4 Model of pri-miRNA processing and localization RAN AGO2 DROSHA PMC4870071__F1 Hepatocyte growth factor/mesenchymal epithelial transition factor and phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway, and their inhibitors evaluated in gastric cancer patients HGF PTEN GRB2 MTOR PMC3094203__F3 Peroxisome proliferator-activated receptor G (PPARG) is a ligand-activated nuclear receptor with potent anti-inflammatory properties that modulates the immune inflammatory response IL10 CD36 IL4 CD163 PMC8037155__F2 Leptin signaling pathway STAT3 PC NPY GRB2 AgRP MTOR PMC3329985__F4 Top Networks Associated With MK-801 Treatment Identified by Ingenuity Pathway Analysis SDHA RARA VRK1 SFN SNAP25 MYC HTT PMC12030371__F1 Penoxsulam’s Effect on Chlorophyll Synthesis and the Metabolism of Foxtail Millet POR CPO UROD UROS PMC3369606__F2 Role of DCs in the pathogenesis of GVHD CD40 ICOS CD80 FAS VCAM1 IL1B PMC9069066__F5 Differential Physiological, Transcriptomic, and Metabolomic Responses of Paspalum wettsteinii Under High-Temperature Stress SDHB PML PMC5482322__F1 The Plasticity of Cancer Cell Invasion AMT ARHA PMC5216695__F7 Beta-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response IGF1R VEGFA IGF2 PMC4132766__F1 Metabolic pathways for PA production LPA TG HEL-S-5 PC MTOR PMC12119316__F3 CHMs and natural compounds suppress the progression of AS by inhibiting the activation of NLRP3 inflammasome SIRT3 NLRP3 SIRT1 SIRT6 MYD88 PMC2856676__F1 Comparative Genomics of Flowering Time Pathways Using Brachypodium distachyon as a Model for the Temperate Grasses RFWD2 MAF1 RFT1 CRY1 PRR7 EFS ID1 CAT56 PRR5 PRR9 ELF4 MSI1 CRY2 AGL EHD1 ELF3 PMC7828702__F11 TGF-Beta-related oxidative stress signaling pathway in HTMCs (created in BioRender.com) SMAD2 SMAD4 PMC7246985__F6 Proposed model of Amuc_1434* effects on LS174T cells BAX PMC8810793__F8 Overall schematic diagram CDC2 RAD50 MRE11A H2AX ATM ANKHD1 CCNB1 YAP1 PMC9653766__F1 Predictive and Prognostic Role of RAS–RAF–MEK–ERK Pathway Alterations in Breast Cancer: Revision of the Literature and Comparison with the Analysis of Cancer Genomic Datasets RASGRF1 DUSP5 SOS1 RASGRP3 RPS6KA2 RPS6KA1 PLXNB1 CNKSR1 PTEN MAP2 RCE1 MYC PIN1 DUSP2 DUSP3 ERF KSR2 RASA2 ICMT RASAL1 MDM2 SPRY1 RASAL3 MAPK1 RASGRP4 JUN ETS2 SPRY4 RASGRF2 KSR1 PTPN11 DUSP4 KRAS FOS HEL-S-34 HRAS SPRY2 RASA3 RAPGEF2 FOSL1 RAPGEF1 SCRIB RPS6KA3 MAP2K1 PMC3725129__F1 Proposed BP metabolic pathways and their representative metabolites BAP1 AKR1C1 HEL-S-165mP AKR1C4 PMC9708800__F4 Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy GSDMD NLRP3 IL18 IRAK1 TRAF6 NOX4 IRAK4 SIRT1 IL1B MYD88 PMC6160134__F2 TGFB signaling and apoptosis TBK1 CITED2 CASP8 SMAD6 IRF7 VEGFA RUNX2 BCL2L11 MYC TRAF6 DUSP2 BCL2L1 MAP3K1 BCL10 SOS2 GDF15 CASP3 GADD45B BCL2 PMC4147234__F1 Infectious tolerance that depends on a nutrient depleted microenvironment maintained by Treg cells within tissues TPH1 HDC BCAT1 ARG1 FOXP3 MTOR PMC4147234__F2 MTOR pathway in T cells RHEB RICTOR TSC1 HEL-S-28 IL2 FOXP3 PMC7886103__F9 Mechanism for protection of MgIG against ATO-treated cardiotoxicity BAX IL16 TLR4 PMC7739562__F7 Diminished canonical Beta-catenin signaling during osteoblast differentiation contributes to osteopenia in progeria APC GSK3B RUNX2 LEF1 CTNNB1 PMC3880276__F9 Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2 PRR5 TSC2 DEPTOR PMC5943138__F2 Control of B-1a cell development by instructive BCR signaling PREB PMC7557502__F1 Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease BAX ERBB4 ERBB2 GRB2 MTOR SRC PMC8965007__F5 Cross-Talks Among Bone Morphogenetic Protein (BMP) Signaling and Other Prominent Pathways Involved in Neural Differentiation SMAD1 DKFZp781O1323 SHH SMO PMC8965007__F6 Cross-Talks Among Bone Morphogenetic Protein (BMP) Signaling and Other Prominent Pathways Involved in Neural Differentiation SMAD1 APC CTNNB1 PMC7564605__F1 IGF-1 signaling pathways SMAD1 DKFZp781O1323 ULK1 SMAD2 GSK3B IGFALS SMAD4 BNIP3 PTEN IGF1R IRS1 CTNNB1 EIF4E RHEB TSC2 TSC1 IGF1 PMC9273796__F1 In silico structural and functional characterization of Antheraea mylitta cocoonase CTRL LAT2 NACA PMC4919052__F10 Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq STAT3 PYCARD TGFB1 LEP SMAD4 HIF1A CCL2 SPI1 XBP1 PAX7 IL-21 IFNG STAT1 CEBPD GDF15 CEBPB SMARCA4 IL1B ZFP36 FOXA1 HMGB1 IL10 JUN SP1 STAT2 IRF1 MIF IL5 IRF6 IL24 FOXO1 FOXO3A NFKB1 RELA EDN1 NFE2L2 EP300 IFNB1 EGR2 REL BCL6 PMC8785230__F1 ERRG, a new player in the type I IFN arena TF IFNAR2 IFNAR1 IRF3 IRF7 PMC6310611__F2 Metabolomics reveals the limitations for the in vivo application of GNF-351 due to poor absorption and high metabolism F5 F2 F3 AHR CYP1A1 CYP3A4 PMC4452148__F2 Notch signaling pathway NUMB NOTCH2 NOTCH3 MYC NOTCH1 PMC2872207__F4 Akt signaling pathway RHEB TSC2 RICTOR TSC1 PTEN MTOR PMC4452148__F3 Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 NLK CCND1 TEF CTNNB1 PMC6372678__F6 Mitochondrial superoxide dismutase 2 mediates Gamma-irradiation-induced cancer cell invasion STAT3 SULF2 SRC CTNNB1 PMC3256499__F2 VEGF pathway and site of action of the inhibitors VEGFB VEGFC VEGFA PMC6545365__F1 Schematic Representation of the Biogenesis and Secretion of ExosomesExosomes are formed as intraluminal vesicles (ILVs) RAB27A RAB27B PMC4089153__F1 Sooner and later IL25 HMGB1 TSLP PMC6682688__F5 ErbB/PI3K pathway regulation by miR-326 ERBB3 BAD CCND2 AKT3 GSK3B ERBB2 MDM2 MTOR VEGFA MYC PMC6406032__F2 Scheme summarizing the role of TRP channels in cardiac fibrosis TRPM7 TRPV3 TRPV2 TRPC4 TRPC1 TRPV1 ARHA TRPC6 TRPM6 TRPC3 PMC8416736__F3 Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations KLF4 FAS CCL2 IL1B SIRT6 FADD PMC8416736__F4 Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations NLRP3 IGF1 TLR4 ABCA1 IL1B PMC9595130__F3 Ferroptosis and musculoskeletal diseases: “Iron Maiden” cell death may be a promising therapeutic target SLC3A2 ACSL3 GPX4 LPCAT3 BAP1 FACL4 HEL-S-89n SLC7A11 POR SIRT3 ATF3 FTH1 TPD52 HEL-S-64p PMC5996875__F4 Fibroblast growth factor receptors and genes that are involved in FGF pathway were analyzed by IPA in KC iPSC compared with normal iPSC HRAS STAT3 PLCG1 HGF MAPKAPK2 FGFR1 FGFRL1 GRB2 PMC4637293__F1 Anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients STAT3 BATF FOXO1 MTOR PMC2872207__F1 TNF-induced NFKB pathway TRADD TNF CCND1 PMC6350302__F5 Proposed model of PI3K activation in CM-RES clones EGFR PTEN IGF1R MTOR PMC2860895__F1 TOM1L2 and genes associated with Alzheimer's disease in the human interactome ARVCF EHD2 STXBP1 EHD3 RAB6B STX12 PSEN1 SLC30A8 SLIT2 QK3 PRDX5 DRAP1 APP CTSF KIFC3 TOM1L2 APOE SLC13A5 KCNH3 WBP2 RAB11B CROT PSEN2 GSTT1 LBP CNNM2 PMC2872207__F3 Jak/STAT signaling pathway LIF IL6 PMC7946999__F3 Different redox state between naïve CD4+ T cell and synovium in rheumatoid arthritis PMC3507479__F1 An expanded role of the tumor suppressor TSC1 in T cell tolerance RHEB TSC2 PLCG1 TSC1 EGR2 PMC10144535__F7 Classical MAPK signaling pathway altered by 15 μM 7KCh treatment in mRPE cells and reversion effect exerted by 10 μM SA over this modulation MPL GRB2 PMC10902464__F1 Galactose metabolism and CG pathophysiology HEL-S-19 PMC7566900__F2 BMAs-derived adipocytokines regulate behavior of metastatic breast cancer cells in the bone marrow CMKLR1 IL16 TLR4 FABP4 ARHA CAP1 PMC11977057__F6 Mechanism by which phanginin A activated SIK1 to promote glucose uptake in skeletal muscle JUP SIK1 HDAC5 HDAC7 PMC7796379__F2 Scheme of the mechanisms underlying chemotherapy-induced peripheral neuropathy (CIPN) in mice treated with paclitaxel (A) or oxaliplatin (B) CXCL12 HMGB1 TLR4 APC PC CXCR4 PMC7433558__F4 IVF-ET对胎盘绒毛FAK信号通路基因表达的影响Effect of IVF-ET on gene expression of FAK signaling pathway in placental villi CDC42 CRK BAD VASP BRAF BCL2 HEL-S-28 PTEN GRB2 SRC CTNNB1 PMC8065725__F6 Wnt/Beta-catenin signaling pathway in chronic HCV infection and HCV clearance without (A) or with (B) metformin treatment MYC CCND1 CTNNB1 PMC8867697__F1 Inflammation and Cardiovascular Disease Associated With Hemodialysis for End-Stage Renal Disease HEL-S-62p CS CP PMC4814460__F1 Autism spectrum disorders (ASD) candidate genes cluster into functional networks, and the two most prominent are synapse structure/function and protein translational control RHEB DAB1 TSC2 TSC1 MTOR PMC11148314__F4 Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging ACTR2 CGAS PMC2805399__F8 A proposed working model of the complex Sertoli cell-germ cell interaction describing the mechanism by which Sertoli cells trigger germ cell apoptosis following MEHP-induced Sertoli cell injury FAS SP1 NFKB1 MMP2 PMC3236216__F5 Distinct Peripheral Blood RNA Responses to Salmonella in Pigs Differing in Salmonella Shedding Levels: Intersection of IFNG, TLR and miRNA Pathways POLL IL33 AIM2 POLI IRF7 PMC10531892__F9 Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients HEL-S-99n PYCARD NLRP3 HEL-S-162eP PMC4563693__F7 Harnessing endogenous stem/progenitor cells for tendon regeneration TNC HEL113 COL3A1 SCX TNMD PMC10531892__F8 Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients HEL-S-99n PYCARD NLRP3 SPDL1 IL1B PMC4746415__F2 Expression of genes involved in the fibroblast growth factor (FGF) signaling pathway during goat pre-implantation development CDX2 SOX2 GATA4 PMC10136283__F7 KEGG pathway map for Wnt signaling pathway SIAH1 ROCK2 APC SMAD4 RYK BAMBI RBX1 SFRP4 SOST INVS RHOD STOM NOTUM NLK PMC8218506__F4 Cornuside I promoted osteogenic differentiation of bone mesenchymal stem cells through PI3K/Akt signaling pathway HEL164 CENPM AURKA BUB1B NCAPG NEK2 KIF20A ZWINT CCNA2 CCL5 CXCL8 CXCL3 KIF23 BIRC5 CDCA5 CENPK CENPU CENPL CENPF CENPN SPDL1 ANAPC15 KLHL13 UBE2S RNF130 CENPA PSAP SMURF2 SKA1 KIF15 DLGAP5 CDC20 GPR37 HEL-S-62p GABBR2 CENPE MYLIP FOXM1 HJURP PRC1 TTK ACKR3 KNTC1 CDCA8 SPAG5 CCNB1 TOP2A CDC2 KIF11 NUF2 RRM2 KNTC2 CXCL2 CXCL6 S1PR1 SPC25 NUSAP1 ADRA2C CEP55 RNF182 KIF18A HCTP4 PMC3709125__F1 Gene regulatory networks in mammalian sex determination CYP26B1 VNN1 CBX2 DHH NR5A1 CBLN4 CTNNB1 RSPO1 FGFR2 STRA8 DMRT1 PGC FOXL2 SOX9 SRY FST FGF9 WNT4 AMH GATA4 SOX8 PMC6776881__F1 Proposed working model of omega-3 PUFAs induced inhibitory effect on inflammation and autoimmunity STAT4 SOCS3 GATA3 PMC4710172__F2 Calcineurin-NFAT pathway: Activation and regulation DYRK2 COX2 ATF2 MDM2 GATA4 CABIN1 PMC4710172__F3 Promotion of cancer development and progression by NFAT MDM2 CABIN1 CCND1 PMC4710172__F4 Inhibition of the calcineurin-NFAT pathway at multiple levels INCA1 COX2 MDM2 PMC6357680__F9 Selected enriched KEGG pathways among DETs between S41 and S43 during tail resorption LEP AFP APP FADD PMC6557020__F2 Mechanisms of the SLIT/ROBO pathway as an oncogene in cancer ROBO2 ROBO3 SLIT2 GSK3B CTNNB1 PMC8249877__F1 Novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development LATS1 PIEZO1 VEGFC AMOT RHO NF2 SRC PMC8249877__F2 Novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development LATS1 PROX1 VEGFC LATS2 RAF1 SOX18 PMC3853754__F1 The mitochondrial life cycle PINK1 OPA1 MFN1 MFN2 MFF PMC9706587__F9 Development of functional nanomedicines for tumor associated macrophages-focused cancer immunotherapy SIRPA CD47 CSF1R PMC8096694__F1 Potential mechanisms by which Nrf2 signaling is regulated via protein interplay as a therapeutic process and in the pathogenesis of heart failure HEL-S-101 FYN AREL1 KEAP1 FN3K SIRT6 PMC6832489__F1 Wnt/Beta-catenin signal transduction pathway in homeostasis APC GSK3B AXIN1 LRP5 LRP6 AXIN2 CTNNB1 PMC8096694__F2 Epigenetic regulations of Nrf2 signaling by noncoding RNAs in the pathogenesis of heart failure BACH1 KEAP1 CRIP2 SIRT1 SIRT6 PMC6832489__F2 Schematic view of sex determination WT1 SF1 SOX9 SRY FGF9 WNT4 AMH RSPO1 PMC8096694__F3 MI-induced cardiac-derived EVs potentially regulate myocardial and brain Nrf2 signaling pathways by intra- and inter-organ communication AREL1 KEAP1 TNF PMC12209371__F1 Role and research progress of the MET signalling pathway in targeted therapy for osteosarcoma STAT3 MACC1 HGF MTOR CTNNB1 PMC8385202__F3 Multi-functional roles of forkhead box protein O in skin aging and diseases SERPINB2 CCL20 NOTCH1 PMC11177995__F8 Schematic diagram for the mechanism underlying the apoVs-mediated rescue of the impaired OVX MSCs biological function and their capacity to improve osteoporosis TGFBR2 APC LRP5 LRP6 CTNNB1 PMC7338457__F8 PD-L1 promotes tumor growth and progression by activating WIP and Beta-catenin signaling pathways and predicts poor prognosis in lung cancer RPS6 PDK2 MTOR CTNNB1 PMC8249877__F3 Novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development PROX1 PIEZO1 VEGFC ORAI1 FOXC2 PMC4835216__F6 Prostaglandin-mediated inhibition of PTH-stimulated Beta-catenin signaling in osteoblasts by bone marrow macrophages COX2 PTH CTNNB1 PMC6661542__F2 Mechanisms involved in the regulation of glycometabolism in T2DM by RC UCP2 INSR RBP4 GIP INS IRS1 PMC4076815__F1 Typical PDA cell is depicted showing schematics of representative metabolic pathways that are altered in the disease in response to oncogenic Kras RPE GOT2 RPIA GLS HK2 GFPT1 HEL-S-32 ME1 PMC11491146__F7 Molecular mechanisms by which CCN2 regulates the activity of TRPV4 channels under mechanical stimulation in fibrochondrocytes SOX9 CTGF PMC10417430__F8 Synergistic effect of N3a with HSPs and mTOR inhibitors in lymphoma cells: Summary of the therapeutic scheme followed in our study, with major findings highlighted in bold MDM2 MTOR PMC8178367__F5 Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells POR BAX CASP12 ELF2 BCL2 BOK APP ATF4 TRAF2 PMC5927454__F15 Amelioration of CCl4 induced liver injury in swiss albino mice by antioxidant rich leaf extract of Croton bonplandianus Baill CYP2E1 PMC3871217__F12 Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways OGT ITGB1 HEL-S-162eP EGFR PDC PMC10417430__F4 Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level SMG1 PIK3CD PIK3R2 CYCS GSK3B PIK3R1 HDAC3 RB1 HSPD1 HEL-S-1 MDM2 APAF1 SMARCA4 PERP TOX4 TOX3 DDB2 ZMAT3 TSC2 CDK5 ZMAT2 RNF20 SESN1 SESN2 SIRT1 PPM1D FAS PIK3R3 CD82 PML SFN PTEN PPP2CA MTOR SUMO1 GTSE1 SUMO2 UBTF YWHAQ CCNB1 CCND1 HEL2 YWHAG CDK4 CDC2 CCND3 THBS1 CDKN2AIP MTA2 RRM2 HDAC1 CCNE2 PRKDC CASP3 CHEK1 EP300 TRAF2 YWHAZ PMC8616169__F4 Oncogenic KRAS: Signaling and Drug Resistance EGF EGFR MTOR KRAS PMC8074531__F1 Simplified model of insulin-stimulated translocation of the GLUT4 glucose transporter in skeletal muscle SNAP23 VAMP2 PAK1 RAC1 IRS1 PMC2752022__F2 FoxO factors in endothelial cells PBX1 VCAM1 CCND1 PMC2752022__F3 Akt-FoxO pathway in regulation of heart size TG MTOR PMC8560795__F2 Targeting Sphingolipids for Cancer Therapy SMS tmp_locus_29 SPHK1 HEL-S-5 SPP1 PMC11894248__F3 An example of the complexity of p21‐activated kinase (Pak1) signaling in a ventricular cardiac myocyte CDC42 PAK1 RHO CP PMC11894248__F4 Scheme illustrating ON and OFF states of the canonical Hippo signaling pathway LATS1 MOB1A MOB2 PMC8224699__F2 Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis EN2 EN1 PMC10451660__F3 AhR signaling pathway AHR AHRR CYP1B1 SRC PMC6941088__F2 The classical and alternative nuclear factor-KB (NFKB) signaling pathways LTB RELB IL1B PMC6374618__F4 Schematic relationships between the wound-induced signal transduction mechanisms for the sesquiterpene biosynthesis and regulation in Aquilaria species for the agarwood production MYB IPP MYC PMC11899273__F2 Schematic diagram of LPS clearance: LPS entering the systemic circulation binds to HDL in the blood to form an LPS–HDL complex TLR4 IL6 VCAM1 MYD88 PMC2796930__F7 FGF-receptor signalling in the generation of hindbrain neural cell diversity SOX9 SHH OLIG2 PMC11899273__F3 Increased expression of FABP4 in LSECs may represent a potential target for liver injury CXCR3 FABP4 CXCL10 PMC8308051__F3 Reelin Alleviates Mesenchymal Stem Cell Senescence and Reduces Pathological Alpha-Synuclein Expression in an In Vitro Model of Parkinson’s Disease CD44 VWF CD36 CHAD CD47 PMC3329512__F7 The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism FAS CIC PDC PC PMC3329512__F3 The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism MME PDC PC PMC6478549__F1 An overview of major metabolic pathways in resting and activated fibroblasts GLS PHGDH F2 AIP PSAT1 PSPH PMC3329512__F4 The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism CIC PDC PC PMC4841705__F3 Regulation of Macrophage NO Production by H HMOX1 NOS2 SLC7A2 ARG2 PMC6165502__F1 The BMPR2 signaling pathway illustrating the potential canonical (green) and noncanonical (grey, blue) targets that can be activated BMPR2 CLIC4 SMAD1 DKFZp781O1323 ID2 ARHA ID1 RAC1 ID3 SMURF1 FKBP1A BMP2 SMURF2 PMC3499814__F2 RIG-I signaling pathway and inhibition by influenza A viruses (Figure adapted from ) TBK1 MAVS TRIM25 TANK IRF3 ATF2 TRAF3 TRAF6 PMC3499814__F3 Type I IFN signaling pathway and inhibition by influenza A viruses (Figure adapted from ) STAT1 IRF9 IRF7 ISG15 JAK1 PMC4246236__F1 Cholesterol metabolism, lipid rafts and cellular prion propagation NPC1 HMGCR APOE ABCA1 PMC8583941__F2 Deacetylation of Transcription Factors in Carcinogenesis BAX SIRT3 SIRT7 PTEN MDM2 SIRT2 SKP2 SIRT1 SIRT6 PMC7875488__F7 A HH/Gli-Foxf1-Wnt signaling network controlling Sox9+ chondrogenesis FOXF1 SOX9 NOTUM SHH IHH WNT4 WNT7B PMC3737553__F6 Our proposed model for two distinct pathways in ICL-induced ATR signaling TOPBP1 ATR ATRIP RAD17 PMC10874752__F13 miR-140-y targets TCF4 to regulate the Wnt signaling pathway and promote embryonic feather follicle development in Hungarian white goose APC GSK3B TCF4 CTNNB1 PMC5702629__F5 Enriched canonical pathway for toll-like receptor signaling at 48 hps with dsRNA TIRAP TLR3 TLR4 TLR9 CD14 CPO IRF3 TRAF6 TNF LBP IRAK4 PMC4129529__F1 Cell-proliferative signaling pathways in lung cancer cell ERBB3 ERBB4 EGFR ERBB2 PMC5410752__F1 Schema of the migratory modes of the excitatory neurons during neocortical development and molecular mechanisms downstream of Reelin signaling that control neuronal migration CDH2 CP PMC8313358__F2 Posttreatment Downregulation of Type III Interferons in Patients with Acute Brucellosis APC IL10RA PMC7216002__F1 Heme biosynthesis pathway (left) and the principle of HAL mediated PpIX production enhancement with dimethylsulphoxide (DMSO) or deferoxamine mesylate salt (DFO) (right) SLC25A38 HMBS ABCB6 HAL ABCG2 FECH ABCB10 UROD UROS PMC4742122__F6 The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets EGF EGFR SRC RAC1 PMC2593012__F2 Gene expression data mapped on the Mus musculus fatty acid synthesis pathway FASN HEL-S-5 ACACA PMC7730327__F2 TAp63A acts as the central integrator for DNA damage signaling in oocytes BAX ATR ATM PMC2593012__F3 Gene expression data mapped on the mouse insulin signaling pathway JUN MAPK13 MAL MAPK10 FAP PMC9110800__F2 Genetic and Epigenetic Interplay Define Disease Onset and Severity in Repeat Diseases CTCF MSH2 MSH3 GC PMC3260921__F2 Integrin signalling pathway STK24 PDCD10 CCM1 ARHA PMC3825669__F3 KEGG “cell cycle” pathway relevant to NRF1 target genes CDC2 STAG2 C6 CDC20 PCNA CDC6 STAG1 ORC6 SMC3 APC SMAD4 ORC1L MYT1 ORC3 SKP2 ORC2 RAD21 CDK7 E2F4 CDK2 MDM2 CDC25B PMC3825669__F4 KEGG “Parkinson’s disease” pathway relevant to NRF1 target genes HTRA2 TH CASP9 LRRK2 KY CASP3 SNCA PMC3825669__F6 IPA “regulation of eIF4 and p70S6K signaling” pathway relevant to NRF target genes ELF4 RPS6 PAIP1 ELF2 PAIP2 GRB2 ELF3 IRS1 EIF4E PMC8481579__F5 Paeoniae Radix Alba in the Treatment of Non-alcoholic Fatty Liver Disease Based on Sequential Metabolites Identification Approach, Network Pharmacology, and Binding Affinity Measurement LEP INSR LEPR IL6 INS TRAF2 IRS1 PMC3383919__F1 Schematic model of the Hippo signaling cascade in mammals LATS1 BIRC5 PATJ AMOT AREG PMC8381548__F1 Therapeutic strategies in METex14 skipping mutated non-small cell lung cancer STAT3 HGF GRB2 SRC PMC1315902__F2 Multiple roles for kinases in DNA replication FEN1 PCNA C2 PMC6651423__F2 Mechanism of Activation for the Non-Canonical and Alternative NLRP3 Inflammasome Pathways NLRP3 TLR4 RIPK1 FADD MYD88 PMC3366472__F2 TLR-4 signaling in cancer HMGB1 TIRAP MAL CD14 IRF3 MYD88 PMC3375870__F1 miR-23a, a critical regulator of “migR”ation and metastasis in colorectal cancer JUN FBXW7 RHOB MTSS1 SRC MYC RAC1 HES5 PMC8514722__F7 NFIL3 Facilitates Neutrophil Autophagy, Neutrophil Extracellular Trap Formation and Inflammation During Gout via REDD1-Dependent mTOR Inactivation MTOR NFIL3 IL1B PMC3277529__F1 Proposed model for TIMP-1–mediated suppression of the Wnt/Beta-catenin pathway via let-7f in human mesenchymal stem cells (hMSCs) TIMP1 APC GSK3B LRP5 LRP6 CD63 AXIN2 CTNNB1 PMC3032697__F15 Time course changes in cytokine network pathways of lungs from 9 V/null mice MPL CD163 TNF MMP15 ARG2 CCL1 PMC6709637__F9 Summary diagram CD44 TGFBR2 TGFB1 TGFBR1 PMC11766572__F1 MYD88 and IRAK signaling pathway IRAK1 TRAF6 TNF IRAK4 MYD88 PMC5099458__F1 Canonical and noncanonical Notch signaling pathways KEAP1 CTNNB1 PMC5520166__F3 Regulatory role of ubiquitin on RIP1 and RIP3-dependent cell death SHARPIN TRADD HAP1 MLKL TNF CYLD PMC9325968__F2 Immunological Synapse: An Emerging Target for Immune Evasion by Bacterial Pathogens ZAP70 CD80 CEACAM1 LAT EBP APC USF1 RAB7L1 RAC1 PMC5427230__F1 The theophylline metabolic pathway CYP1A2 CYP2E1 CYP3A4 PMC4374755__F7 Involvement of DNA-PKcs in the Type I IFN Response to CpG-ODNs in Conventional Dendritic Cells in TLR9-Dependent or -Independent Manners STAT1 TLR9 TRAF3 TRAF6 IRAK4 MYD88 PMC4826884__F2 Immune signaling in C SGK1 PMC3654365__F5 Summary of the metabolic pathways in which the metabolites described in this paper are involved VIT CIT PMC6996089__F1 Bile acid synthesis pathways HSD17B4 CYP8B1 BAAT ABCD3 GCA HSD3B7 CYP46A1 CYP7B1 CYP27A1 AMACR AKR1C4 SLC27A5 PMC8202879__F7 LncRNAs induce oxidative stress and spermatogenesis by regulating endoplasmic reticulum genes and pathways TF POR UGT1A3 SP1 GCLC XDH GPX3 CYP1A1 GPX1 CYBB PMC11936574__F1 Interleukin-18 signaling pathway and its functional binding with IL-18 receptor NLRP3 IRAK1 TRAF6 TNF IRAK4 IL18BP MYD88 PMC8052259__F1 m6A regulates innate immune signaling pathways TBK1 MAVS TLR4 YTHDF2 IRF3 TNF MYD88 PMC4254984__F4 C-peptide-initiated signaling cascades ARHA IRS1 PMC8052259__F2 m6A regulates IFNB and the type I IFN response STAT1 STAT2 IFNAR2 IRF9 IFNAR1 YTHDF2 IRF3 YTHDF1 JAK1 TYK2 PMC8052259__F3 m6A regulates immune cell function SOCS1 CD40 CD80 TIRAP TLR4 JAK3 YTHDF1 CISH MYD88 PMC6913124__F7 Putative role of miR-146a in CVB infection TLR3 IRAK1 TRAF6 PMC3128433__F3 Complement cascade, hemolyisis, and eculizumab CD59 HEL-S-62p CD55 PMC3562086__F1 Connecting the Insulin pathway to the Drosophila autophagy machinery RHEB ATG10 TSC2 RICTOR ATG3 ATG12 ATG5 PMC9663387__F1 Optogenetic interrogation of cell signalling: human neuropsin (hOPN5) represents a potent tool for controlling the Gq pathway with light GAL TRPC6 PMC5883378__F2 Two signaling pathways TLR3 TLR4 MAL TLR8 TLR5 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC4285539__F9 Signaling model for IP-10 production induced by MRP8/MRP14 TBK1 TLR4 IRF3 MYD88 PMC9139286__F4 DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease CASP8 NLRP3 DDX3X FADD PMC8657588__F1 Toll-like Receptors (TLRs) Mediated Inflammation in Pancreatic Cancer Pathophysiology TLR1 TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 TLR7 IL6 CCL20 MYD88 PMC3597360__F4 Pathways leading to actin polymerization in the myogenic response CDC42 VASP ARHA SRC PMC6717912__F1 Immune cell development and trafficking to the heart CXCL9 CXCR3 CXCL1 CCR2 ELL CXCL2 VCAM1 CCL5 CXCL8 IL1B PMC8516553__F5 Insights into the Role of Oxidative Stress in Ovarian Cancer APC LRP5 LRP6 CTNNB1 PMC8600399__F8 MicroRNA-218-5p in sevoflurane-induced protective effects in hepatic ischemia/reperfusion injury mice by regulating GAB2/PI3K/AKT pathway MTOR TNF GAB2 PMC8323643__F1 Interleukin-10: A double-edged sword in breast cancer STAT3 GSK3B SOCS3 IL10RA TYK2 PMC8019201__F3 Molecular mechanisms of the role of enhancer of zeste homolog 2 (EZH2) in a polycomb repressive complex 2 (PRC2)‐independent manner TF STAT3 TRIM28 JAK3 RELA RELB EZH2 MYC GATA4 CTNNB1 RORA PMC5860992__F1 Adapting Secretory Proteostasis and Function through the Unfolded Protein Response ATF4 EIF2A XBP1 PMC6801718__F10 Summary of data showing TGFB1 recruitment of miR-143 and miR-145 to RISC to destabilize CFTR mRNA and impair the corrector/potentiator-mediated rescue of F508del-CFTR TGFB1 AGO2 CFTR PMC11816580__F1 In MASLD, CS affects the AMPK signaling pathway in different ways in the liver (A), adipose tissue (B), and ileum (C) to perturb lipid metabolism TG FAS KEAP1 MTOR SIRT1 IRS1 MPO PMC11816580__F2 Molecular mechanism of CS-induced hepatocellular damage BAX NOS2 FAS GSDMD NLRP3 CYP2E1 IL13 BCL2 ME1 TNF CISD3 FADD PMC11816580__F3 Downstream signaling in regard to the promotion of liver fibrosis by CS STAT3 TIMP1 SMAD2 GSK3B SMAD4 DVL2 CS TNF COL3A1 CTNNB1 COL1A1 MMP2 WNT4 PMC7611882__F4 Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation POLD3 MAPDA DBT NAGK ADPGK DPM3 ACADM PISD CERS6 POR ASAH2 ALDH2 PNP PLAT SUCLG1 GUK1 HAL ASPH CHKB COASY CYP26B1 ECHS1 CAD ACO2 CERS2 ALG2 BST1 ARG1 EXT1 DGKG HACD4 ADSL PGAM1 HEXB MTHFD1 POLA1 B3GNT5 LIAS DPM1 ESD PSAT1 HEL-S-87p ACAD8 PMC5129526__F1 Transcriptional regulation of glucose metabolism during active TB disease and in PBMCs stimulated with Mtb ACLY HEL60 ACSL3 ENO2 IDH3B FACL4 MTOR CS SDHAF1 PARP12 PARP11 SUCLG1 SUCLA2 NDUFB1 IL18 HEL-S-32 MDH2 HEL-S-26 PFKM PARP10 FH ACSL5 HEL-S-133P PARP14 HK2 LAMTOR3 LDHB PDK3 IRS1 P4HTM SDHD SDHA PGAM1 SDHB DLAT ACSL1 PDK4 ENO3 HEL-S-68p HEL-S-162eP HEL-S-49 SUCLG2 PFKL HEL-S-87p PMC4222074__F4 Network links between 23 genes in pathway of mismatch repair and three driver genes POLD3 SSBP1 MSH3 PMS2 RNF7 RPA1 LRPPRC CTNNB1 LMO7 LRIG3 PMS1 LRIG1 MLH3 RPA3 ABLIM1 PMC12141845__F1 Canonical Wnt signalling pathway with osteokine and pro-inflammatory marker inhibitors SOST LRP5 LRP6 PMC8550759__F8 RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy ROR1 RNF43 ROR2 BRAF PMC9277259__F1 EMT in the DNA damage response, double‐strand break repair pathway choice and its implications in cancer treatment ERCC1 RAD52 ATR RAD51 PARG BRCA2 DUT RIF1 BLM SHLD3 PARP1 SHLD2 SHLD1 BARD1 FANCD2 BRCA1 PAXX APLF RNF8 ATM PARP3 PARP2 PALB2 TWIST1 PMC5888819__F1 Dysregulated genes and their associated microRNAs in the KEGG MAPK-signaling pathway in colorectal cancer MAX TBCA FAS CDA MOS ME2 GRB2 NLK GCK BDNF PMC1525228__F9 Diagram depicting the mechanism by which NGF may inhibit GSK-3B and promote axon growth NGF GSK3B PTEN BDNF PMC8096351__F8 Identification, Biological Activities and Biosynthetic Pathway of Dendrobium Alkaloids IPP COCH MVD MVK PMC3170890__F1 IL-10 signal transduction and hypothesized treatment by dual gene therapy STAT3 SET PMC5869528__F9 Toll-like receptor signaling pathway CD40 TIRAP CTSK TLR9 CD14 CPO IRF3 TRAF3 TRAF6 IRAK4 RAC1 TLR3 TLR4 LBP FADD PMC4169706__F2 Genome-wide association analysis of anti-TNF drug response in rheumatoid arthritis patients C6 CHRNA3 DAB1 RGS20 KCNA5 SLC25A13 WIPF1 LINGO1 BMP5 COL13A1 RORA PRKG1 PMC4701046__F2 Signaling pathways in melanoma CDC42 BAD NF1 BRAF NRAS PTEN MTOR CCND1 PMC4148370__F3 Differentially expressed genes (DEGs) in the T-cell receptor signaling pathway ZAP70 CBL FYN BCL10 LAT ITK GRB2 LCK CDK4 PMC4148370__F2 Differentially expressed genes (DEGs) in the B-cell receptor signaling pathway SYK CD81 BTK BCR CD22 BLNK CD19 LYN DAO PMC2854193__F1 Autophagy Genes as Tumor Suppressors ATG101 ATG10 TSC2 ATG3 TSC1 ATG12 UVRAG AMBRA1 PTEN MTOR PMC11201619__F2 Targets to Search for New Pharmacological Treatment in Idiopathic Parkinson’s Disease According to the Single-Neuron Degeneration Model GSTM2 KEAP1 SNCA PMC3759859__F2 Oncogenic role of the AKT signaling pathway RHEB TSC2 BAD RICTOR TSC1 PTEN MDM2 MTOR PMC3759859__F3 p53-induced cell cycle control and apoptosis BAX ATR ATM MDM2 PMC3759859__F4 Interplay between p53 and AKT/mTOR in regulating autophagy RHEB TSC2 ATR TSC1 ATM PTEN MTOR PMC6102891__F7 Signaling pathway of OS and pregnancy (a brief view) BCL10 KEAP1 FOXO3A GCLC PMC9331760__F4 HDACs in the Response of Cancer Cells to Cellular Stress and the Potential for Therapeutic Intervention HDAC3 HDAC1 BACH1 KEAP1 MAF SIRT1 PMC3359119__F1 mTORC1 signaling and regulation of pancreatic Beta-cell mass EIF4B MAP4K3 GSK3B PTEN MTOR DEPTOR IRS1 EIF4E RHEB TSC2 EEF2K NR1C1 RICTOR TSC1 RALA PMC4403188__F6 GAi1/3-mediated activation of TLR4 in response to LPS TLR4 RELA CD14 IRF3 IL6 TRAF3 LBP IL1B MYD88 PMC9213371__F1 NFKB in control of regulatory T cell development, identity, and function RELA RELB F8 FOXP3 PMC7917472__F4 PI3K-Akt signaling pathway regulated by EZP SYK BAD RAF1 FRK RBL2 PTEN CD19 MTOR EIF4E TSC2 BCR RXRA MEI1 NPB MDM2 PMC3612853__F1 Signaling and transcriptional regulation of Th17 polarization STAT3 BATF IL21R MTOR IRF4 RORA GATA3 IFNG STAT1 RARA RUNX1 AHR STAT4 FOXP3 IL23R PMC10398793__F4 In the IPA data software the disease and function analysis of the RNA sequencing data from Primbio MAPK1 MAP1LC3A GSK3B HIF1A MTOR MYC CXCL8 H1-2 ESRRA FOXO1 HSF1 MAPK12 CP PMC6912474__F2 Organelle homeostasis imbalance signaling pathways MLX ATF4 EIF2A XBP1 PMC4848680__F4 Eicosanoid synthesis pathways: Arachidonic acid is a polyunsaturated fatty acid that is released from the cellular membranes by cytoplasmatic phospholipase A2 (PLA2) LTB LOX COX1 PMC3482945__F3 Pathway related to prostate cancer STK35 MCCC2 ADIPOR2 SRM SFN PHKA2 NEK3 FECH DGKZ PARM1 PMC3696647__F7 Schematic diagram for HIF-1A functions in cap-dependent translation of selective mRNAs, cell proliferation, and tumorsphere growth of cancer cells in low O2 environment RHEB TSC2 EIF4G1 TSC1 RBM4 EIF4E3 MTOR PMC7162614__F6 Adding MASP1 to the lectin pathway—Leprosy association puzzle: Hints from gene polymorphisms and protein levels TG FCN3 CR1 PMC12144611__F3 Decoding CD24: Roles of chemoradiotherapy resistance and potential as therapeutic targets GIT2 STAT3 CD24 ARF6 PTEN PMC8776696__F4 Transcriptomic profiling reveals gene expression in human peripheral blood after exposure to low-dose ionizing radiation NDUFB6 HLA-DQA2 HLA-DQB2 HLA-G B2M OAS3 CTSG HBB HBA2 OCM ORM2 PMC7661869__F1 ARHGAP24 inactivated Rac1/Akt/NFKB in acute pneumonia RAC1 ARHGAP24 IL1B PMC9422807__F2 Comparing the Cytokine Storms of COVID-19 and Pandemic Influenza CXCL9 FAS IF2B1 CCL3 MAL CXCL10 TNF PMC3136090__F5 Signaling schematic representation: The postulated signaling pathway involved in this study TUB CDK2 RHO PMC7515907__F3 Interconnections between cilia, aging and Alzheimer’s disease genes PMCH PPARG SHC1 SLC2A4 GSK3B PSEN1 STUB1 RB1 HMOX1 TRAF3IP1 DRD2 PDPK1 IL16 IFT81 PRKCA PDCD6IP A2M NPY CDK3 MDM2 BBS2 IDE DNAH7 GATA1 DNAJB1 RAD51 VPS37A APOE ARL13B TSG101 PTK2B VEGFA TNF FOS TP53BP1 RPGRIP1 DYNLT3 RICTOR ZMYND10 CCDC40 BRCA1 DRC7 DNAH14 HEL-S-49 PSEN2 PTCH1 RSPH3 CALM1 IFT20 BCL2 ENO1 GRB2 BAK1 HTRA2 TF SPAG1 BLMH DNAAF2 PAXIP1 EGFR BACE1 DHCR24 TERT INS EIF2S1 HEL-S-80p INSR CLU EEF1A1 VPS4B CDC2 BAX JUN BIN1 NPHP1 PRNP TERF1 IFT140 RPA1 NR3C1 DYNLRB2 NR1C1 PKD1 CBY1 BBS7 IFT57 BBS5 CASP3 BBS4 NFKBIA EP300 MCHR1 PMC8956889__F2 Ileum transcriptional response to prolonged supplementation with phytogenic product containing menthol, carvacrol and carvone DBF4 CDC45 ORC6 CDC6 CDT1 ORC1L ORC3 ORC2 PMC4910530__F1 Lost & found: C9ORF72 and the autophagy pathway in ALS/FTD TBK1 TMEM106B WDR41 VCP CHMP2B C9orf72 PMC5861487__F3 TGFB pathway LTBP1 SMAD1 THBS1 SP1 SMAD6 SMAD4 NODAL ARHA TNF BAMBI IFNG RBX1 E2F4 FST SKP1 PMC2874810__F3 Ingenuity Pathway Analysis Network CPVL CD59 OSM CCL3 CCR2 CYCS SOCS3 SLC16A3 EREG TRIB1 IER2 HEL-S-11 NFKBIZ ZFP36 FOSB MXD1 JUNB NAMPT AREG PVALB CNTNAP3 RASGEF1B FAM167A HOXB13 CXCR4 PSAP EGR2 RAP1GAP EGF NPHS2 IFIT3 DUSP2 CASR TLR7 RGS1 GRIA4 CSTA GPS2 IL1B TNNC2 EGR1 NGL1 SGK1 SDCBP KLF6 PER1 KCNV2 CXCL2 PTGS2 NFKBIA TRIM29 PMC8307213__F6 Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis PINK1 OPA1 MFN1 SIAH3 PMC4281589__F1 Retinoic acid (RA) synthesis pathway in the gut CD80 TLR5 PMC8493399__F8 Cyy260, a novel small molecule inhibitor, suppresses non-small cell lung cancer cell growth via JAK2/STAT3 pathway STAT3 BAX CASP3 MTOR PMC3246074__F2 Vitamin A and immune regulation: Role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance CTNNB1 MYD88 PMC6689321__F3 Cross-talk between the CDK4/6 and mitogenic signaling pathways in cancer RHEB TSC2 CDK6 TSC1 GSK3B GRB2 CDK4 PMC4288257__F5 Malonylated proteins in glucose and fatty acid metabolism pathways ACLY HEL107 EHHADH FAS HMGCL FABP1 ACD PYGL ACAT1 PC HEL-S-32 HEL-S-26 ACSF2 FH ACSL5 HEL-S-133P GPD1 PGAM1 ACSL1 PGAM2 ALDOB ACAT2 HEL-S-68p HEL-S-162eP FBP1 PMC7261485__F9 ATP11B deficiency leads to impairment of hippocampal synaptic plasticity MAPK14 SYP DLG4 ARC PMC7427992__F7 TG-resident HSV-specific memory CD8+ TRM cells downregulate the T cell exhaustion associated pathway and confer protection from ocular herpes in HSV-1 infected asymptomatic humans and HLA transgenic rabbits CD44 CXCR3 TG TIGIT CD69 CCR7 LAG3 PMC5216743__F6 Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells TSC2 BTK TSC1 TLR4 EIF4E PMC3994729__F4 Expressional regulation of genes linked to immunity & programmed development in human early placental villi STAT3 JAK3 JAK1 CDNF TYK2 PMC7542157__F2 Molecular mechanisms of NADPH homeostasis in cancer MTHFD2 ME3 MTHFD1 GOT2 ME2 DHFR MTHFD2L HEL-S-32 ME1 GLS2 HEL-S-26 NNT PMC9710037__F2 Mathematical model of the cell signaling pathway based on the extended Boolean network model with a stochastic process EGFR ERBB2 GRB2 PMC4815038__F8 ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies DDIT4 MCL1 ELF2 BCL2 ATF4 PMC7987945__F6 Transcriptome Analysis of Ovarian Follicles Reveals Potential Pivotal Genes Associated With Increased and Decreased Rates of Chicken Egg Production DLG2 NCAM2 GABRB2 NDUFB9 FANCL RPLP2 GABRG3 NDUFAB1 NDUFS3 NDUFA11 NDUFS4 TRIP12 GABRG2 GABRB1 NCAM1 GABRE NDUFS6 CACNB1 NDUFC2 DLG4 GTF2E2 D2HGDH GABRB3 PRNP KCNF1 NDUFB10 NPL LRRTM3 PMC5764779__F4 Pathway affected commonly in liver metastases irrespective of cancer types PLEK THSD4 COX2 CD14 TNF PSD2 PMC6200414__F3 Phospholipid-binding tumor suppressor ANXA7 linked to the interrelated FGF8 and cyclin E pathways through Ca/phospholipid signaling in prostate cancer STAT3 SRI CRAT HGF SPR EGFR GAS MAPKAPK2 PTEN PTK2B CYP1A1 RAC1 FGF8 HRAS CBL SOST IGF1 CCNE1 GRB2 CP BDKRB2 PMC7905841__F1 Ceramides in Metabolism: Key Lipotoxic Players CERS3 CERS5 UGCG CERS1 CERS2 KDSR CERS6 PMC6850018__F1 Modeling therapy resistance via the EGFR signaling pathway MAX GNB5 EGFR PTEN MTOR KRAS PMC4495601__F7 Novel drug target identification for the treatment of dementia using multi-relational association mining MAX ECSIT FAS CD14 NTM DAO FLNA NGF MOS NLK GRB2 TRAF2 ERI1 PMC6936066__F8 The explanation of TGFB regulates cell fate and plasticity as well as multifunctional cellular responses via SMADor non-SMAD pathways or ITGB1 pathway band with fibronectins and tenascin-C PI3K/AKT pathway ITGB1 HEL-S-28 CTNNB1 PMC4200801__F3 Current strategies to generate tolDCs CD40 CD80 IL10 IL6 MTOR GATA3 PMC3816662__F1 PI3K/Akt/mTOR signaling pathway BAD PTEN MTOR MYC EIF4E RHEB MLST8 TSC2 RICTOR TSC1 BCL2 MDM2 CCND1 PMC4040939__F2 Wnt pathway, sclerostin, and DKK1; effects of monoclonal antibodies on bone.(a) Scl and DKK1 bind Wnt coreceptors LRP5/6 to inhibit Wnt binding and signaling to decrease bone formation LRP4 DKK1 LRP5 LRP6 PMC2692251__F2 HuR and/or AUF1 differentially regulate mRNAs encoding cell cycle and Erk1/Erk2 Mapk signaling-related genes in MCT-1–transformed cells SOST SHE PMC7933428__F7 Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics KEAP1 ELL PMC10929203__F1 Exosomes in psoriasis pathogenesis IL36G IL6 TNF PMC10931608__F11 Signaling pathways involving MISP STAT3 OIP5 MISP PMC8267809__F1 Activated PI3Kinase Delta Syndrome—A Multifaceted Disease CD40 BCR IL7R CD19 PTEN IL6R PMC3346900__F4 (A, B) Schematic view of the Fas/Fas-ligand (FasL) apoptotic signaling pathway HTRA2 BAX FAS PMC3236216__F8 Distinct Peripheral Blood RNA Responses to Salmonella in Pigs Differing in Salmonella Shedding Levels: Intersection of IFNG, TLR and miRNA Pathways TXNDC12 RAB5C CCR5 MCL1 LYZ CTSS SOCS3 SPI1 ABCA1 NCF1 MYD88 IFNG ATP6V1C1 ATG3 ETV6 CASP4 CEBPD IL18 MX1 CEBPB NFKBIZ TNFAIP6 LMO2 ETS2 NR1H3 LCP2 SDCBP CFD MPZL1 TNFSF13 IRF9 CD14 NCF4 VAV1 IRF3 PTK2B DSC2 PICALM ATF3 IL1RN RELA FES AIF1 KLF5 TNFSF10 GADD45A SDHC CYBB PMC6593294__F1 Possible pathways underlying the DLL1/Notch signaling pathway defect SMAD1 MAML1 ADAM17 SMAD2 SHH SNW1 ADAM10 ATF4 RUNX2 NOTCH1 ADA PMC8679799__F1 Human NLRP1: From the shadows to center stage NLRP1 DPP9 GSDMD IL1B PMC9323564__F16 Altered Transcriptional Regulation of Glycolysis in Circulating CD8+ T Cells of Rheumatoid Arthritis Patients COX6A1 NDUFB10 NDUFA12 NDUFB11 OGDH UQCRHL HEL-S-162eP DLD ATP5MG IDNK PMC9589221__F6 Melatonin signalling in Schwann cells during neuroregeneration GDNF SHH BDNF PMC5553784__F3 Reactome functional interaction network corresponding to 520 genes showing differential expression in the T0 (fasting) vs T2 (7 h after eating) comparisons SOCS1 DBP EED ABCC1 TIRAP BOC TXNIP PBX1 CYCS NR4A3 SDC4 TWIST2 HECW2 SKP2 TIAL1 MAPK4 EPHB2 SOX9 NLRP3 SCO2 NFE2L3 UBB CCR1 RPS21 MYH10 TLE4 IRF2BPL RPL35A ATF3 RPE RPS20 HIRA CLDN7 HECW1 MMP25 PPIE PPIF CREB5 CHAC1 THBS2 TANK CREM CEBPD HDAC5 DKK2 RND1 CASC3 MYH2 TJP3 BARX2 SELE PER2 C1orf51 HMGN1 BCL2L11 GATA3 MAFF HEL-S-69p NEO1 HDAC9 KLF5 ABCC6 SLC27A4 PMC6121269__F2 Pathogenicity and factors associated with the disruption of the normal cellular activity APC ARHA CTNNB1 PMC5669051__F4 Endocannabinoid System in Neurodegenerative Disorders LPA GAA PTPN22 AMT GIP PMC9323564__F13 Altered Transcriptional Regulation of Glycolysis in Circulating CD8+ T Cells of Rheumatoid Arthritis Patients TH SLC3A2 FLCN PTEN MTOR SKP2 TNF PMC12174527__F2 Metabolic Pathway of RFC MTHFD1 DHFR SHMT1 HEL-S-51e PMC5050510__F4 Repeatability of cortisol stress response in the European sea bass (Dicentrarchus labrax) and transcription differences between individuals with divergent responses VWF FH CPB2 HEL-S-62p F5 PLG F7 CR2 F11 CS C4A C2 F2 CD9 F10 F3 C9 PC A2M F8 PMC5669051__F1 Endocannabinoid System in Neurodegenerative Disorders RAF1 ARC BDNF PAX6 PMC5904274__F3 Molecular mechanisms of ZIKV underlying the neuropathogenesis RHEB STAT1 TSC2 TRIM25 STAT2 IRF9 F3 IFITM3 PTEN MTOR JAK1 TYK2 PMC2796113__F2 Models of Merlin-dependent membrane receptor distribution in flies and mammalian cells EGF NHERF1 EGFR NF2 PMC8114846__F2 Review of Recent Research on the Role of MicroRNAs in Renal Cancer RIPK3 DKK3 TSC1 DKK1 SMAD4 PTEN MTOR VEGFA TRAF6 KRAS TRIM21 PMC5471068__F2 Pathogenesis of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia and mechanisms underlying its relapse STAT3 EPOR MDM2 MTOR MYC RAC1 PMC3917509__F1 The multiple roles of protein ubiquitylation PCNA H2AX TRAF6 POLN PMC6977568__F1 HER2 signaling pathways in cancer cell and cardiac myocyte NRG1 PER2 PMC11351910__F7 Wnt/Beta-Catenin signaling pathway and miRNAs in pancreatic cancer PAF1 APC GSK3B LRP5 LRP6 MYC CTNNB1 PMC7705175__F1 Autophagy-lysosomal pathway (ALP) HEL-S-130P CTSL PMC7069334__F1 Simplified Galactomannan biosynthetic pathway in coffee seed IDE GAL PMC3402068__F1 What Goes On Must Come Off: phosphatases gate-crash the DNA damage response ATR RAD51 BRCA1 H2AX BRCA2 ATM MDM2 RTEL1 MDC1 SLX4 EME1 PMC4651738__F8 Schematic diagram illustrating the proposed signaling pathway FIG4 TNF MPO PMC3022727__F6 IPA pathway graphical representation of Aryl Hydrocarbon Receptor Signaling ALDH18A1 HEL-S-53e HEL-S-21 GSTT2 LOC51064 DHFR MGST1 CCNA2 NCOA7 RB1 CDKN2A NR1B3 ALDH1A3 CDK6 CCNE1 GSTA4 RARB MGST2 NR3A2 AHR GSTM5 MED1 NFIA HSPB3 GSTA3 GSTM1 POLA1 CDKN1A GSTM3 NFKB1 CDKN1B CHEK1 PMC3059560__F1 Targeting the embryonic gene Cripto-1 in cancer and beyond HEL-S-62p NODAL PMC11351910__F3 PI3K/AKT signaling pathway and miRNAs in pancreatic cancer EGF EGFR PTEN MUC4 MTOR PMC3022001__F12 Schematic representation of effect of depletion of the syntaxin-5 complex on the autophagic pathway SEC22B SNX5 PMC2819159__F2 Obesity, Diet and Risk of Non-Hodgkin Lymphoma DHFR TYMS MTR PMC11351910__F4 KRAS signaling pathway and miRNAs in pancreatic cancer SPRY2 EGF EGFR GRB2 PMC11351910__F5 JAK/STAT signaling pathway and miRNAs in pancreatic cancer NMI NOS2 EPO MYC SOCS6 PMC11351910__F6 TGFB signaling pathway and miRNAs in pancreatic cancer SMAD2 SMAD4 SMURF2 PMC4373477__F1 Simplified diagram of the Ras/ERK pathway and SST effects through PTPs, SHP-1 and SHP-2 TSC2 TSC1 ATF1 GRB2 SRC CCND1 SST PMC4373477__F2 Simplified diagram of PI3K/Akt pathway and SST effects through PTP SHP-1 BAX TSC2 BAD TSC1 CCND1 SST PMC6122736__F7 Mechanism of XWL-1-48 inhibits growth of breast cancer cells BAX H2AX ATM MDM2 PMC9173833__F35 SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1 IL13 IRF1 IL6 TNF PMC4544746__F7 STALK CELL PHENOTYPE DEPENDS ON INTEGRATION OF NOTCH AND SMAD1/5 SIGNALING CASCADES ID1 HES1 PMC6770389__F1 The infectious spleen and kidney necrosis virus (ISKNV) induced the changes of glucose metabolism PDHX RPE FH MAL CIT PMC4615001__F2 Mitoribosome assembly lines MTG2 HEL97 SPG7 RBFA DDX28 MTG1 PMC5797605__F1 mTOR signaling during autophagy RHEB TSC2 TSC1 ULK1 TFEB DEPTOR PMC5797605__F2 mTORC1 and mTORC2 complexes RHEB TSC2 NR1C1 TSC1 C2 MTOR DEPTOR PMC5882221__F2 Ubiquitin-mediated regulation of the core Hippo pathway components RNF146 HERC4 ITCH AMOTL2 USP9X WWP1 LATS1 FBXW7 YOD1 LATS2 CUL4A SIAH2 NEDD4 AMOT PMC9406970__F2 Modulating Chaperone-Mediated Autophagy and Its Clinical Applications in Cancer GFAP PHLPP1 PMC8076600__F4 Cytoskeleton Dynamics in Peripheral T Cell Lymphomas: An Intricate Network Sustaining Lymphomagenesis CDC42 AURKA HELLS VAV3 VAV1 MTOR ARHA PLK1 RAC1 RHOU ICOS ALK HDAC6 PMC7917105__F4 Genome of Medicago polymorpha provides insights into its edibility and nutritional value as a vegetable and forage legume CAD SI PMC5078608__F7 Ca2+Signaling Pathway Proteins that Are Regulated by Homeostatic ScalingIntracellular signaling pathways HEL-S-31 ATP2B1 PLCB4 HPCAL1 PPIF CACNA2D2 HPCAL4 MAPK8IP3 CHRM1 EGFR STIM1 ATP2A2 PPM1E PPP3CA MAPK8 ARHGAP32 MAPK3 PRKCB GNAS MYLK ARHGAP26 PRKCE ADCY9 BCR ARHGAP21 WWOX CACNA2D3 MAP4K3 STIM2 ERBB4 PPM1H STK24 ARHGAP12 FOS TIAM1 NFKB1 GNA11 EDNRB CACNB4 PMC6913443__F2 Multifactorial regulation of hepcidin expression in hepatocytes STAT3 SMAD1 TFR2 DKFZp781O1323 TLR4 BMP2 SMAD4 HFE IL6 HFE2 PMC5985159__F1 Acquired Resistance to Drugs Targeting Tyrosine Kinases EGF CASP9 HGF PTEN IGF1R MTOR IGF2 DEPTOR IRS1 RHEB TSC2 TSC1 IGF1 GRB2 PMC8773742__F1 Recombinant Proteins-Based Strategies in Bone Tissue Engineering WNT5B BMPR2 SMAD1 DKFZp781O1323 WNT3A BMP4 APC BMP2 SP7 RUNX2 LEF1 CTNNB1 PMC8870354__F2 Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma SLC7A11 ATF4 XBP1 TRAF2 PMC5994557__F1 Specific microRNAs (miRNAs) in T helper 17 (Th17) cell differentiation and targets for current treatments CDC42 ACHE STAT3 OGT SMAD2 SMAD4 IL21R PTEN IRF4 TRAF6 GFI1 TOB1 FOXO1 AHR DNAJA2 IL23R PMC7431833__F6 Schematic diagram depicting the possible mechanisms BACE1 APP SIRT2 PMC8087485__F1 Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine CYP2E1 PMC7848966__F4 Crosstalk of the NF‐KB pathway involved in glioma angiogenesis with other signalling processes TNLG1B EBP TNF TRAF2 PMC7505114__F3 IVM-induced PAK1/Akt/mTOR-mediated autophagy.IVM promotes degradation of PAK1 by ubiquitination/proteasome pathway, thereby inhibiting the Akt/mTOR signaling pathway HEL-S-62p PAK1 ATG14 MTOR PMC10930821__F6 Enhancement of drug sensitivity via molecular therapies targeting tumor growth and antitumor immunity CD80 CDK6 CDK4 PMC7505114__F5 PAK1 cross regulate multiple signal pathways.RAS activation directly initiates PAK1, MAPK and PI3K/Akt pathway PAK1 MTOR CTNNB1 PMC10930821__F5 Molecular mechanisms of immunogenic cell death and tumor-specific immune activation via unfolded protein response (UPR) activation by anticancer drugs P2RX7 IFNG HMGB1 P2RY2 TLR4 FPR1 ATF4 PMC10930821__F3 Summary model for the c-Jun N-terminal kinase (JNK)/c-Jun/activator protein 1 (AP-1)-mediated signaling pathway in anticancer drug-induced cell death BAX FAS PMC11772327__F1 Proposed biosynthetic pathway of LC‐alkanes pentadecane and heptadecane in Pogostemon cablin MCAT FAS CER1 PMC5584126__F8 CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors BRCA1 ROR2 SOX2 CD55 LCK PMC10930821__F1 Common intrinsic and extrinsic apoptotic signaling pathways induced by anticancer drugs HTRA2 BAX TRADD FADD PMC4052759__F1 Autophagy regulates p62/SQSTM1 levels to control multiple pro-oncogenic signaling pathways ATG101 ATG12 KEAP1 ULK1 MTOR ATG5 PMC4742205__F7 INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma INSM1 GSK3B SHH PMC7994325__F2 Importance of ICOS+ Th1 cells in ICI therapy IFNG ICOS APC CTLA4 PMC7470804__F8 Proposed mechanisms for the GluOC therapeutic effects on hyperglycemia and hepatic steatosis in KKAy mice TG FAS FOXO1 GSK3B PMC7378634__F1 Cellular sources and effects of IL-22 STAT3 STAT1 TYK2 PMC10525260__F3 Multi-Faceted Role of Cancer-Associated Adipocytes in Colorectal Cancer WNT10B STAT3 LIN28B PDE3B WNT3A PRDM16 CXCL1 UCP1 FABP4 CXCL2 PLOD2 TNF PMC4826209__F6 WWOX modulates the ATR-mediated DNA damage checkpoint response ATR ITCH WWOX ATM SSB PMC8721139__F1 Potential of Ferroptosis-Targeting Therapies for Alzheimer’s Disease: From Mechanism to Transcriptomic Analysis VIT TF SLC3A2 LOX STEAP3 GPX4 NFE2L2 SLC7A11 PMC4450766__F5 EGFR pathway and the model of the effect of EGFR/MEK/EGFR + MEK inhibition on the pathway in RAS‐active NSCLC cell lines RPS6 RAF1 EGFR KRAS PMC7723971__F1 ROS/NLRP3 signaling pathway participates in sepsis-related immune responses NLRP3 TLR4 IL1B PMC10960420__F12 Patterns of effectiveness of C STAT3 FOXP3 PMC9664061__F1 Promising research direction for colorectal cancer immunotherapy: The regulatory mechanism of CCL5 in colorectal cancer STAT3 MSC CCL5 CXCL10 TNF CCR1 CTNNB1 PMC4613973__F8 Working models for the failure of PRL-PRLR-JAK2-STAT5 signaling to activate proliferation in adult human Beta-cells PRLR PRL PMC9999652__F3 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment ACLY GAA ITGB4 BNIP3L MYC HEL-S-51e MXI1 PMC9999652__F7 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment SIX1 ANXA2 ALOX15 SLC7A5 HEL-S-30 TUG1 PMC8641784__F3 SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease SUMO3 SUMO2 RNF4 SENP1 PML SENP6 SENP2 MEF2C SENP3 PMC9999652__F8 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment PDLIM2 PFKL PMC3248866__F2 HPV 16 E5 enhances growth factor signalling pathways BAX EGF EGFR SRC PMC9999652__F5 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment RAB27A MTOR PMC12115344__F1 Diagrammatic overview of key pathways involved in ALD STAT3 TBK1 FAS CGAS NLRP3 IRF3 PMC7971547__F3 Role of inflammasomes/pyroptosis and PANoptosis during fungal infection ZBP1 NLRP3 AIM2 IRF1 IL1B CARD9 MYD88 PMC7905024__F1 CGAS-STING and TLR9 signaling in response to the recognition of host-derived self-DNA as a DAMP HMGB1 CGAS TIRAP TAB3 TLR9 IRF3 TRAF6 IRAK4 MYD88 PMC9641212__F1 Immune response induced by novel coronavirus infection MLKL IL33 CASP3 IRF1 TNF PMC6955855__F5 Terpene and terpenoids biosynthesis IDI2 IPP IDI1 MVK PMC11395325__F7 Proposed mechanism by which HAE improves lactation FAS TSC1 PTEN DEPTOR PMC8867093__F2 Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells GPX1 HEL-75 PMC4030844__F1 Simplified schema of interconnections between small ubiquitin-related modifier (SUMO) pathway proteins and other factors regulating androgen receptor (AR)-dependent transcription HDAC1 SUMO3 SENP1 SENP2 PMC4030844__F2 AR-independent promotion of prostate cancer (PCa) cell proliferation and angiogenesis by the SUMO pathway SUMO1 SENP1 SP3 CCND1 SENP3 PMC6102867__F2 Regulation network of circRNAs in cancer CDC42 STAT3 ITCH EGFR EZH2 VEGFA E2F5 FMNL2 CTNNB1 LATS1 CDK6 CCNE1 FOXO3A CDK2 JAK1 BIRC3 PMC9523121__F1 Hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review POMC NPY ATF4 SOCS3 AgRP EIF2A XBP1 PMC6433691__F7 Model of JS‐K‐induced anti‐tumour activity in gastric cancer BAX APAF1 HEL-S-44 PMC4633914__F1 Functions and interactions of CIP2A and the “oncogenic nexus” of CIP2A are presented in a schematic representation of the major interacting partners of “oncogenic nexus” of CIP2A protein CIP2A FOXO1 PPP2R1A MDM2 PMC9658791__F3 Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury ATF4 XBP1 PMC5676474__F7 Oxidative Stress Alters the Profile of Transcription Factors Related to Early Development on In Vitro Produced Embryos HSPD1 MORF4L2 GPX4 DDIT3 NFE2L2 GADD45A GPX1 HEL-S-44 PMC10968836__F2 Comparison of the signalling pathways triggered by TNFR1, Fas and TRAIL agonist receptors FAS ADAM17 TRADD RIPK1 TNF TRAF2 PMC3956136__F1 Canonical Wnt B catenin signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC10968836__F3 TRAIL canonical signalling pro-apoptotic pathway RIPK1 FADD PMC11812559__F2 Beyond Tumors: The Pivotal Role of TRIM Proteins in Chronic Non-Tumor Lung Diseases SMAD2 SMAD4 PMC10968836__F4 DR5 non-apoptotic signalling pathways RIPK3 MLKL SPHK1 RIPK1 ATF2 CCL2 CXCR4 TRAF2 FADD PMC10968836__F5 TRAIL-induced non-canonical pro-tumoral signalling via DR5 secondary complex formation STAT3 TRADD EGFR PTEN ATF2 MTOR RHO CCL2 RAC1 ROCK1 CPN2 SRC TRAF2 UNK FADD PMC6829074__F1 microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways TRADD FOXO1 FOXO3A TRAF2 FADD PMC6829074__F2 microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways IRAK1 TRAF6 IRAK4 IL18BP MYD88 PMC9043558__F1 Ror-Family Receptors in Development, Tissue Regeneration and Age-Related Disease ROR1 ROR2 FLNA PMC3929401__F1 Deficient Phosphorylation of Stat1 in Leukocytes Identifies Neutralizing Antibodies in Multiple Sclerosis Patients Treated with Interferon-Beta STAT3 STAT1 STAT2 IFNAR2 IFNAR1 MX1 STAT4 JAK1 TYK2 PMC4394599__F2 Molecular pathway of glycolysis in NSPCs PDK4 HK2 PTEN ENO1 TIGAR SCO2 MTOR MYC PMC4394599__F3 Molecular pathway of glutaminolysis in NSPCs GLUD1 GLS SIRT4 MYC SLC38A5 PMC3712731__F4 Display of wild-type and disease pathway diagrams LRIG1 EGF PLCG1 EGFR CDC37 PMC5414760__F6 Potential role of CBX2 in the regulation of sex development TBX2 CBX2 TSNAX TEX10 PBX1 TSPYL4 INSL3 FGF2 SF1 FOXL2 SOX9 SRY SOX3 WNT4 FZD1 MTM1 PMC9357883__F3 Molecular mechanisms underlying the role of hypoxia-inducible factor-1 A in metabolic reprogramming in renal fibrosis HEL-S-133P PTEN MTOR PMC10193374__F1 In wound healing, CTHRC1 can recruit additional M2 macrophages to the wound site to promote skin repair and activate the TGFB and Notch pathways SYK ROCK2 HEY2 APC CTHRC1 MTOR ARHA DPAGT1 RAC1 GSK3A ROCK1 GRB2 HES1 NOTCH1 HES5 PMC7376803__F1 AMH and FSH signaling pathways, cellular outcomes, and main functions in IVF practice SMAD1 DKFZp781O1323 SMAD6 SMAD4 FSHR CTNNB1 FOXO1 HAT1 MMP2 TLX2 CDK2 AMHR2 AMH SRC PMC5942524__F2 Organismal Injury and Abnormalities, Cardiovascular Disease, Nutritional Disease Ingenuity Pathway Analysis (IPA) Network LTA NTRK2 OPRM1 PTGS2 MAP2 DRD2 SLC6A3 DRD4 BCR CNR1 MAP2K1 BDNF ABCB1 PMC9554349__F3 Genetic and pharmacological tools to study the role of discoidin domain receptors in kidney disease STAT3 DDR1 CD36 CTNNB1 PMC5942524__F3 Hereditary Disorder, Organismal Injury and Abnormalities, Respiratory Disease Ingenuity Pathway Analysis (IPA) Network CRP IL10 IL1A PMC8375320__F3 Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development PIEZO1 WWTR1 BMP4 ERBB2 YAP1 PMC8375320__F1 Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development LATS1 PIEZO1 WWTR1 LATS2 FLT4 PIEZO2 YAP1 PMC3881602__F1 Interplay between regulatory T cells and metabolism in immune regulation ICOS RICTOR CD36 CTLA4 FOXP3 MTOR GATA3 PMC6407036__F3 Biomarkers in the Pathways in cancer TH BAX EGF CASP9 SMAD1 BAD MSH2 MSH3 GEM SMAD2 APC MAL SMAD4 MTOR POR CBL POLK CASP3 GHB2 PMC6407036__F4 MiRNAs involve in different types of cancers and colorectal cancer biomarkers SPRY2 MMP16 SHC4 APC TP63 BCL2 DYM ATM CYC1 PTEN ZEB2 SOX4 PMC4553385__F2 Treg suppression CD80 IL10 APC PMC5661628__F1 CS synthesis CSGALNACT2 B3GAT1 CHSY1 GAL B3GALT6 CSGALNACT1 XYLT1 CHSY3 CHPF PMC4621004__F1 RAGE signaling pathways CDC42 LPA HMGB1 EGR1 ARHA SRC RAC1 PMC4306304__F1 Hereditary hemorrhagic telangiectasia is a genetically heterogeneous disorder caused by mutations in several genes in the TGFB/BMP signaling pathway ENG SMAD1 DKFZp781O1323 SMAD4 ID1 PMC8668794__F3 Gene expression and epigenetic responses of the marine Cladoceran, Evadne nordmanni, and the copepod, Acartia clausi, to elevated CO2 HEL-S-182mP HEL-S-61p PMC8148155__F1 Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice FAR1 PEMT PMC7947364__F1 Summary of the cellular metabolic effects of hyperglycemia in cancer HK2 EGFR FASN IGF1R GRB2 USP6NL PMC3774704__F1 Galectin-3 is a regulator of metaflammation in adipose tissue and pancreatic islets IL10 NLRP3 TLR4 PMC2810660__F1 Autophagy and NFKB fight for fate TRAF3 REL TRAF2 PMC5541893__F3 Mechanisms involved in initiation, perpetuation, and resolution of inflammatory responses TH S100A8 ANXA1 FPR2 MPO PMC7564048__F3 Crosstalk with the TGFB/BMP SMAD pathway at focal adhesions (FA) BMPR2 ENG PMC6480119__F9 Schematic diagram of EGCG anti-tumor mechanisms based on reverse docking SYK NOS2 PIM1 PLK2 JAK3 NTRK2 IRAK1 IRAK2 TNF KRAS IRAK4 MAP2K4 CDK7 PLK3 BCR PRKCQ IKBKB NTRK1 WEE1 CDK2 PARP3 MAP3K5 APAF1 PMC9143803__F2 New Insights into the Pathogenesis of Giant Cell Arteritis: Mechanisms Involved in Maintaining Vascular Inflammation CXCL9 CD80 CCL18 RAB7A CCR2 CD14 CCL2 CD83 CCL19 CCL21 CX3CR1 CCR7 FOXP3 PMC8466925__F2 Polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis STAR SHBG FSHR LHCGR PMC8554507__F1 Modular map of Bradykinin-mediated inflammatory signaling network BAX PIK3CA CAST PXN OSCAR MTOR VEGFA GNG2 GNB1 GNAS HRAS CLCA4 RASA2 tmp_locus_29 RELA HEL-S-69p PTGS1 GNA11 CHUK PMC11101339__F4 KRAS pathway and KRAS inhibitors MTOR KRAS PMC11101339__F5 Main mechanisms of therapy targeting TME in SMARCA4-UT CXCL9 IFNG FAS APC EZH2 PMC7056627__F1 LncRNA-GAS5/miR-221-3p/DKK2 Axis Modulates ABCB1-Mediated Adriamycin Resistance of Breast Cancer via the Wnt/Beta-Catenin Signaling Pathway DKK2 CTNNB1 PMC2447903__F8 TWEAK killing TRADD TRAF3 TRAF2 FADD PMC7599155__F2 Dna2 is an essential gatekeeper to HR-dependent restart of stalled replication forks PIF1 RAD51 DNA2 PMC8136122__F5 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) SMAD2 APC CTNNB1 PMC8136122__F6 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) EGFR TNF CDCP1 PMC9364940__F1 Ionizing Radiation-Induced Ferroptosis Based on Nanomaterials CGAS GPX4 LPCAT3 FACL4 ATM SLC7A11 PMC8271933__F1 Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products RHEB TSC2 TSC1 BCL2 PTEN MDM2 PMC9225571__F1 Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis FAS AREG PMC8136122__F4 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) TIMP3 EGR1 CTNNB1 PMC5838215__F1 Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder GSK3B SMAD4 PSEN1 CSNK2B CTNNB1 CTBP2 CSNK2A2 CTBP1 CSNK2A1 DKK2 CACYBP SIAH1 ROCK2 LRP5 FZD7 LRP6 DVL2 ARHA RAC1 RBX1 INVS PLCB1 AXIN1 CREBBP NLK DAAM1 PMC8271933__F2 Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products CSH2 C2 PMC5838215__F2 Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder PPP3R1 GSK3B SMAD4 PPP3CA PSEN1 PRKCB CSNK2B CTNNB1 CSNK2A2 DKK1 PRICKLE2 CCND3 SIAH1 ROCK2 LRP5 FZD7 LRP6 ARHA RAC1 RBX1 INVS AXIN1 CREBBP PLCB2 NLK CAMK2G DAAM1 PMC8136122__F2 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) TGFBR2 HMGB1 SLIT2 FSTL1 SMAD2 SMAD4 ATF4 RHO SEMA7A NOX4 SIRT6 PMC6230982__F2 Metabolic pathways involved in anticancer drug resistance TES GLS HEL-S-133P PHGDH HK2 GCLC FASN BRAF LDHB MTOR PMC9028275__F3 Entanglement between Mitochondrial DNA and Tumor Metastasis CGAS ND6 PDC CCL7 TLR9 VEGFA PMC3288605__F2 Pathway of formation and catabolism of HDL particles LPL PLTP ABCA1 PMC2782733__F2 EGFR signaling through the PI3K/Akt pathway EGF EGFR PTEN GRB2 MTOR PMC7760552__F2 Release of TEX and their molecular cargo composition CD44 LOXL2 IGFBP5 CD9 IGFBP1 RHO CD63 PMC7225257__F1 Recent mechanisms of resistance identified in lung adenocarcinoma ATR GDF11 BRCA1 SMAD2 BRCA2 WEE1 ATM MAST1 HCTP4 YAP1 PARP1 PMC7219929__F3 Schematic depicting the response of steroidogenic cells to stressors such as polycyclic aromatic hydrocarbons and ROS SP1 KEAP1 PBR PMC10529884__F1 Report from the 24th Annual Western Canadian Gastrointestinal Cancer Consensus Conference on Colorectal Cancer, Richmond, British Columbia, 28–29, October 2022 MSH2 PMS2 BRAF PMC9510994__F8 Integrated volatile metabolomic and transcriptomic analysis provides insights into the regulation of floral scents between two contrasting varieties of Lonicera japonica TES IPP HMGCR MVK PMC10296705__F2 Biosynthesis pathways of isoprenoids and the biosensors that are responsive to isoprenoids and their precursors IPP TUB PMC5917100__F1 Viruses and the Autophagy Pathway C20orf185 SNAP29 SQSTM1 PMC6438930__F2 Therapeutic targeting of glycolysis, lipid and redox metabolism in CSCs FAS GLS CD36 PMC8441355__F6 Protective effect of Salidroside on hypoxia‐related liver oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways STAT3 CYP2E1 NQO1 PMC8149954__F1 Ironing Out the Details: How Iron Orchestrates Macrophage Polarization NLRP3 IRF3 GMFG ATF4 CCL2 NOX4 IL1B PMC3268617__F2 Dys–Syn–nNOS pathway and miRNAs coordinate the muscle differentiation program HDAC1 POLA1 YY1 PAX7 PMC3954825__F2 DISC1 as a key lead in studying cortical development and associated brain disorders TF ERBB3 DAB1 NRG1 VLDLR APC GSK3B ERBB2 APP DISC1 CTNNB1 PMC3355930__F1 Prostaglandin E2 (PGE2) biosynthesis and signaling COX1 PMC11750270__F8 Therapeutic potential of monomethyl fumarate and aluminum ion combination in alleviating inflammation and oxidative stress in psoriasis KEAP1 NQO1 MAF PMC7757125__F9 Metabolic pathways connecting gene expression, DNA methylation, and targeted metabolomic data MLYCD ACSS2 ACACB PDK4 FASN PDC DLD CS MPC1 PDK2 ACACA MPC2 PMC6230982__F1 Metabolic pathways associated with cancer PGAM1 GOT2 FH GLS HEL-S-133P PHGDH F2 HK2 GCLC FASN HEL-S-26 PMC5916355__F5 Proposed model for nicotine-induced synaptic plasticity in the OFC ERBB4 BACE1 NRG3 PMC7002027__F2 Phagocytosis checkpoints as new targets for cancer immunotherapy CGAS TLR9 TLR8 SIRPA IRF3 TLR7 B2M LILRB1 CD47 PMC3996455__F1 Treg functional stability and its responsiveness to the microenvironment STAT3 CCL3 FOXP3 MTOR STUB1 MYD88 PMC10280140__F11 TGF‐B‐induced PI3K/AKT/mTOR pathway TGFBR2 ATG3 MMP9 MTOR ATG5 IRS1 TGFBR1 PMC9507923__F2 QishenYiqi dripping pill protects against myocardial ischemia/reperfusion injury via suppressing excessive autophagy and NLRP3 inflammasome based on network pharmacology and experimental pharmacology EGFR APP TNF PMC4734073__F4 Strategies evolved by Staphylococcus aureus to counteract innate immune response SCIN HEL-S-62p ADAM10 FPR2 IL8RB CXCL3 PMC5681734__F1 NRG–ErbB signaling pathway ERBB3 NRG2 NRG1 ERBB4 ERBB2 MTOR PMC11873031__F5 Experimental design, analysis and validation TRUB2 SET PMC2989686__F4 Canonical pathways for cardiovascular disease SERPINF2 CPB2 PLG MB PMC3025468__F11 Compartmentalization of TNF-R1 signalling and A-SMase activation CASP9 TRADD HEL-S-130P CASP3 TNF FADD PMC5173045__F7 Proteinase-activated receptor 2 promotes TGF-Beta-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGFB type I receptor ALK5 SMAD2 SMAD4 PMC5721944__F2 Hypothetical schematic connecting basal IP3R mediated Ca2+ release to protein translation, via AMPK and the TOR signalling pathway TSC2 TSC1 MCU PMC6914886__F6 The proposed mechanism by which green tea acts against NAFLD UCP2 NR1C1 ACSL3 HMGCR CD36 FOXO1 ADIPOR2 TLR4 TRAF6 RXRB APOA5 PMC6514668__F1 Schematic representation of the autophagy pathway from reference by Seiliez et al ATG10 ATG3 ATG12 ATG5 PMC3941218__F1 Insulin- and IGF-1-signaling pathways CASP9 TSC2 BAD IGF1 IGF1R MDM2 TBC1D4 IRS1 PMC7113111__F1 Signaling pathways from three ER transmembrane stress sensors during unfolded protein response (UPR) in schizophrenia ATF4 EIF2A TRAF2 UNK PMC4726830__F3 Emerging targets for glioblastoma stem cell therapy MLST8 RICTOR PTEN GRB2 MTOR SRC PMC4120710__F6 Motility, Survival and Proliferation CDC42 ARHA SRC PMC8149954__F2 Ironing Out the Details: How Iron Orchestrates Macrophage Polarization SDHD SDHB NDUFA9 HK2 NDUFV2 GMFG ENO1 RERE HEL-S-44 PMC8149954__F3 Ironing Out the Details: How Iron Orchestrates Macrophage Polarization HDAC3 SOCS1 PMC12000394__F0 Molecular mechanisms of HBsAg suppression of the IFNB signaling pathway and triggering of early autophagy TBK1 SNAP29 IRF3 PMC11276560__F5 DEGs in selenium metabolic pathways of KEGG metabolic pathway map CBL SELE CTH PMC2566525__F8 Schematic view of part of the IGF-1 and integrin signaling pathway genes transcribed by hNCC BAD POTEH PMC5870602__F8 Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform BGLAP CYR61 COL1A1 SP7 RUNX2 TNFRSF11B CTNNB1 PMC11863469__F3 Signaling pathways in GBM ATR APC ATM MDM2 MTOR OTP PMC3335800__F8 MEKK1-MKK4-JNK-AP1 Pathway Negatively Regulates Rgs4 Expression in Colonic Smooth Muscle Cells JUN RGS4 TBP FOS IL1B PMC8875960__F1 Druggable Molecular Pathways in Chronic Lymphocytic Leukemia TF CD79A BTK BCR PLCG2 LYN PMC8178581__F2 Notch signaling pathway involvement in innate lymphoid cell biology IFNG RORC DTX1 KLRG1 IL17RB TLE4 ADAM10 IL23R HES1 GATA3 PMC3374592__F1 Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles GRB2 SRC MYC PMC8178581__F1 Notch signaling pathway involvement in innate lymphoid cell biology FLT3 ID2 ZBTB16 NOTCH1 PMC8875960__F4 Druggable Molecular Pathways in Chronic Lymphocytic Leukemia RELB TRAF3 MAP3K14 TRAF2 BIRC3 PMC7726878__F1 TLR-mediated signaling pathways in response to HSV TLR1 TLR3 TLR4 EGFR TLR9 IRF3 IRF7 MYD88 PMC7726878__F2 Responses of TLRs to EBV and HCMV TLR1 TLR3 TLR4 TLR9 IRF3 TLR7 TRAF3 TRAF6 IRAK4 MYD88 PMC7704407__F4 Proposed pathways of how cAMP and Ca2+ interact and result in increased AQP4 expression via Gs and Gq/11 in the pathology of HE during ALF AQP4 AVP PMC7214667__F1 Janus kinase (JAK)-Signal transducer and activator of transcription (STAT) signaling pathway and its inhibition with jakinibs in synovial fibroblasts CXCL9 CXCL11 STAT3 STAT1 OSM STAT2 OSMR MMP3 SOCS3 CXCL10 TNF TYK2 PMC8616039__F1 Emerging Therapeutic Landscape of Peripheral T-Cell Lymphomas Based on Advances in Biology: Current Status and Future Directions ALK CCR4 MTOR PMC1852708__F6 Illustration of key proteins in the Rho GTPase signal–transduction pathway, focusing on the KALRN, CDGAP, and MYLK genes CDC42 EPHB2 MYLK NTRK1 ARHA RHO PMC3514620__F2 DNA repair pathways and implicated proteins MSH6 ATR ATRIP MPG ATM FANCM PALB2 MDC1 SSB PMC9606818__F2 Effect of narcotics on ferroptosis-related molecular mechanisms and signalling pathways SLC3A2 NR1C1 GLS STEAP3 LPO GPX4 LPCAT3 FACL4 SLC7A11 MDM2 HEL-S-64p HEL-75 PMC10537080__F2 Critical role of platelet in cancer progression and metastasis CD40 ADAM17 MICA VCAM1 ARHA MICB PMC7982411__F1 MEK-mitogen activated protein kinase–extracellular signal-regulated kinase (ERK) signaling cascade of the mitogen-activated protein kinase (MAPK) pathway and phosphoinositide 3-kinase (PI3K)–AKT-serine/threonine protein kinase Akt pathway NRAS PTEN MAP2K1 MTOR KRAS PMC6627192__F5 Ingenuity Pathway Analysis integrating differentially expressed genes and microRNAs between imatinib-naïve (IM-n) and imatinib-resistant (IM-r) gastrointestinal stromal tumor (GIST) samples HEL164 UBE2C E2F8 CDC6 APC E2F7 CD34 GMNN RBL1 MT2A NUSAP1 MCM10 GINS2 LEFTY2 PREX2 GINS1 PMC8533171__F8 Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas CDC42 HGF DTL APC PTEN MIF RAB22A IRS1 CTNNB1 CCKBR RBX1 CCNE2 FBXW7 FLI1 DDB1 UHRF2 MACC1 CDK6 IGF1 RHOB MAPK7 SNX1 CCND1 CDK4 PMC2720036__F1 Selective Raf Inhibition in Cancer Therapy BAD BAG1 BRAF BCL2 PPA2 GRB2 SRC CCND1 PMC3938170__F1 Folate pathway FOLR1 DHFR HEL-S-61p PMC2078333__F1 Summary of known actions of activated ras-p21 in cells, beginning (top, left) when a growth factor binds to its cell receptor JUN GRB2 MYC FOS PMC3443512__F8 TARGETING THE eIF4A RNA HELICASE BLOCKS TRANSLATION OF THE MUC1-C ONCOPROTEIN EGFR MUC1 MTOR PMC8303465__F1 Sex Maintenance in Mammals DMRT1 FOXL2 SOX9 SRY FST WNT4 AMH PMC4290704__F1 Signalling pathway and endogenous antagonists of IL-1B and IL-18 IL1R2 IL18BP IL1B MYD88 PMC2577435__F9 Signaling from LMP1 and TLR to IRF7 activation TLR9 IRF7 TLR7 TRAF6 TRAF2 MYD88 PMC1501125__F1 WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability APC GSK3B PTEN TCF4 CTNNB1 PMC5890151__F2 Treg likely promote tissue repair and regeneration in a tissue-specific manner CXCL12 CCL22 CCL3 EGFR IL33 CCL4 AREG PMC2720036__F5 Selective Raf Inhibition in Cancer Therapy HEL164 PEX5L LTK CSF1 RAF1 TBXA2R RFXANK PIK3R1 PRKCZ MYC DMPK PIN1 MAPK3 KRT19 RB1 KLHL12 PRPF6 PRKCA NRAS GRIN1 SRC MAPK1 FRS2 RABGGTB GNB2 VAV1 HRAS CRK SHOC2 PAK1 RAP1A MAPK7 BCL2 GRB2 KRT18 BAD MAPK8IP3 EGFR BRAF TIMM44 CSNK2B GNB1 PLCG1 KSR2 PRKCE YWHAQ HEL-S-80p INSR OIP5 HEL2 YWHAG ARRB2 GNG4 SPRY4 RSU1 BAG1 RBL2 KRAS HEL-S-34 NR3C1 ARAF GNG2 SPRY2 RAP2A IL2RB RIN1 RRAS NUDT14 JAK1 CDC37 RRAS2 PRKG1 YWHAZ LCK PMC5130114__F1 Disorders of the mTORC1 signaling pathway TSC2 TSC1 PTEN PMC7231083__F1 Type I interferon immune response MAVS TLR3 TIRAP STAT2 TLR4 TLR9 TLR8 IRF3 TLR7 TRAF6 TYK2 MYD88 PMC6731276__F1 Pathway altered on both transcriptomic and epigenomic levels VIP LHB APC MC4R MC2R GNG2 HTR6 CALCRL POMC ADRB1 PTGIR CALCB GNG7 HRH2 PMC7231083__F3 Evasion and inhibition of respiratory virus-induced IFN-I signaling MAVS TLR3 TIRAP STAT2 TLR4 TLR8 IRF3 TLR7 TYK2 MYD88 PMC4728993__F1 Metabolic pathway of phenylalanine (Phe) GOT2 PAH DDC PMC4339543__F2 The Role of the Protein Tyrosine Phosphatase SHP2 in Cardiac Development and Disease INSR ARHA GRB2 SRC PMC139100__F8 Gelsolin-induced epithelial cell invasion is dependent on Ras–Rac signaling PIP5K1A SOS1 PLD2 ARF6 RAC1 PMC4280834__F2 Proposed biosynthetic pathway of diphthamide DPH1 DPH2 DPH6 DPH7 DPH3 DPH5 PMC8447515__F6 Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs STAT3 IGF1 MTOR PMC8847900__F2 Human biosynthetic pathway for trace amines and catecholamines PNMT DBH PMC5569945__F2 Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia RHEB RPS6 EEF2K TSC2 EIF4B TSC1 ARF1 TBC1D7 PTEN CASTOR1 IRS1 PMC5569945__F3 Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia RHEB TSC2 TSC1 TBC1D7 PTEN IRS1 PMC9290485__F3 Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity CYP1A2 CYP2B6 CYP2C19 CYP2C9 CYP3A4 PMC7391788__F7 Ingenuity pathway analysis of genes/molecules that are regulated by thymoquinone in relation to Alzheimer’s disease and inflammation (A), and osteoarthritis and inflammation (B) STAT3 CASP9 TNFSF6 NBN CD14 TNF MPO HMOX1 BCL2L1 TLR4 BMP2 CASP3 CDK2 BCL2 TNFSF10 CDK4 PMC3359641__F3 Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors HRAS BAX HSD3B1 NGFR GSK3B GHRH YY1 GRB2 MAP3K5 BDNF TRAF6 RAC1 PMC8139735__F11 An Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the New Candidate Active Component and Mechanism of Cuscutae Semen-Mori Fructus Coupled-Herbs in Treating Oligoasthenozoospermia TF BCL2 SHE KRT19 PMC6004395__F3 ABA-dependent signaling pathway in response to temperature stress MYB ERF SNRK MYC PMC4350902__F3 Schematic depiction of PTEN functions in nucleus and cytosol with regard to its posttranslational modifications RAD51 APC PTEN MDM2 NDFIP1 PMC5501692__F3 Human endogenous retrovirus-derived gene that can contribute to oncogenesis by activating the ERK pathway and inducing migration and invasion SPRY2 ETV5 EGR1 SPRY4 FOSL1 ETV4 DUSP4 MYC CCND1 FOS PMC7991784__F1 HBV-induced lipid metabolism changes in hepatocytes APOC3 TG ACSL1 FAS NR1C1 SMS HMGCR SCD CYP7A1 LDLR APOA5 PMC7991784__F2 Changes in proteins or metabolites of lipid metabolism pathway affect the life cycle of HBV: potential targets for HBV suppression FAS HMGCR SQLE APOE PC PMC3606625__F1 EGFR-Targeted Therapy in Malignant Glioma: Novel Aspects and Mechanisms of Drug Resistance STAT3 PCNA EGFR PTEN MTOR PMC11766595__F9 TLR4 inflammatory pathway NLRP3 TIRAP TLR4 IRF3 ATF2 TRAF6 LBP PMC9700084__F1 Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury NGF TLR4 CCND1 PMC11936551__F2 LncRNA-MALAT1 acting as ceRNAs and its involvement in the EMT process of retinopathy and regulating the corresponding signaling pathway factors ATAD2 PDE6G STAT3 SAG GUCA1A IGF2BP3 VEGFA STX17 CTNNB1 PMC12023943__F4 Keratinocyte differentiation mediated by either CD9 overexpression or calcium stimulation in mouse keratinocytes LORICRIN CD9 CTNNB1 PMC10311025__F8 Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response GSDMD NLRP3 DFNA5 CHAD PMC3668835__F4 Genomic landscape of small intestine neuroendocrine tumors FLT3 PIK3CA ERBB2 MTOR SRC FGFR2 PMC10463219__F6 Resveratrol ameliorates insulin resistance by improving insulin signaling via the DDIT4/mTOR/IRS-1/PI3K/AKT/GLUT4 pathway DDIT4 MTOR IRS1 PMC3394947__F1 The proteins involved in the different pathways related to eicosanoid biosynthesis MGST3 PPARG NR1C1 LTC4S DPEP2 ACOX3 AHR PTGES PMC5672917__F1 The role of iron in brain ageing and neurodegenerative disorders TF CD200 PMC4673238__F5 Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells TEC JUN CBL FYN LAT ITK GRB2 LCK PMC8293989__F1 Comparisons of Underlying Mechanisms, Clinical Efficacy and Safety Between Anti-PD-1 and Anti-PD-L1 Immunotherapy: The State-of-the-Art Review and Future Perspectives CD80 APC PMC4216462__F1 TGFB signalling pathway in the early mouse embryo IDI2 TF SMAD1 DKFZp781O1323 ID2 SMAD2 SMAD6 SMAD4 NODAL ID1 ID3 GDF3 CRIPTO BMP4 BMP2 PMC4741283__F1 IL10/IL10R signaling pathway STAT3 IL10 JAK3 CD14 IRAK1 IL6 TNF TRAF6 IRAK4 IL6R MYD88 TLR4 JAK1 TYK2 IL10RB PMC3702279__F5 Schematic diagram illustrating miR-185 and ATR function in radiation response TOPBP1 ATR ATRIP RAD17 PMC5691663__F1 Thyroid hormone-induced interference with resveratrol-induced antiproliferation is blocked by tetrac and its nanoparticulate analog SUMO1 HMGA2 RRM2 CTNNB1 PMC5402749__F1 Necroptosis and Cancer RIPK3 MLKL TAB3 RIPK1 TNF CYLD TRAF2 FADD PMC7041258__F4 Gene expression analysis by IPA software (FC ≥ 1.5 and p value < 0.001) showing nuclear factor erythroid 2-related factor 2 (NRF2) oxidative stress response path design activated in NR8383 cells after exposure to ¼ IC50 of NM403 for 4 h PROX1 KEAP1 MAF PMC5940740__F2 Diabetic stressors lead to Schwann cell dysfunction and neurodegeneration CNTF BAD IGF1 DHH RHO PMC3058235__F1 Control of GnRH secretion by growth factors and small molecules produced by glial cells TGFB1 TGFA IGF1 PMC7564143__F3 Four processes model of cardiac regeneration NRG1 OSM PMC3663490__F5 Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer FANCD2 RAD50 MRE11A BRCA1 BAAT H2AX CHEK1 ATM MDM2 MDC1 BLM PMC6237934__F1 PD-1 signal inhibits T-cell receptor (TCR) signaling pathway ZAP70 BATF FOXO1 APC NFATC1 MTOR SKP2 LCK PMC3663490__F6 Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer MSH2 H2AX BRCA2 FANCM FANCA BLM FANCC FANCE RB1 FANCG FANCD2 MRE11A ATM CCND1 PMC7564143__F4 Simplified overview of the classic Hippo-YAP signaling pathway LATS1 LATS2 AMOT NF2 CTNNB1 PMC3638243__F8 The plasminogen (Plg)-dependent pathway of foam cell formation CD36 PLG ABCA1 PIGR CEBPB CD68 PMC7862249__F1 Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities USP14 NBR1 ATG10 ATG3 NEDD4 ATG12 TRAF6 OPTN ATG5 PMC6839531__F11 Schematic showing the proposed dynamic changes in the localization of LHCGR, DENND1A.V2, and RAB5B in various cellular compartments RAB5B CYP17A1 CYP11A1 LHCGR PMC6369476__F1 Potential proinflammatory role of resistin in the pathogenesis of osteoarthritis TLR4 MAL TRAF6 MYD88 PMC8533869__F1 TGFB Signaling in the Pancreatic Tumor Microenvironment TGFBR2 SMAD2 SMAD4 TGFBR1 PMC5666889__F2 A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review HEL-S-134P HEL-S-128m PRDX3 GPX4 HEL-S-2a PRDX5 GPX3 HEL-S-97n GPX1 HEL-S-44 PMC3879372__F10 Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells IL10 PLCG2 STIM1 IRF4 SRC PMC6548059__F1 Components of the autophagy pathway reported to be deviated in neuropsychiatric disorders ATG3 HEL-S-62p PMC8458828__F6 Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma AHR TNF PMC8915814__F3 Versatile Functional Energy Metabolism Platform Working From Research to Patient: An Integrated View of Cell Bioenergetics HEL-S-62p C2 CS HEL-S-64p HEL-75 HEL-S-44 PMC6172368__F3 PPI network based on the interaction of the differentially expressed genes between the M2 and M0 groups SOCS1 PPARG CCL22 SLA FCER2 S100A8 CD1E TYMS CCNA2 GLRX CCNH PRKCH MYD88 WNT5B NFE2 CDCA5 CLEC4A CH25H TLR7 IGF2BP2 CYP27A1 CCL17 CD209 RAB33A FZD2 CD14 IRF4 CD1B TK1 CDKN1A PFKP AQP9 CD1A GINS2 DHRS4 FGL2 CD1C CDK14 ALDH1A2 NPL GADD45A S100A9 WFS1 CARD9 CYBB PMC5790950__F1 KSHV entry by macropinocytosis and trafficking in the human microvascular dermal endothelial cells CHMP5 CHMP6 TSG101 ARHA SRC PMC6172368__F2 PPI network constructed based on the genes with differential expression between the M2 and M0 groups in the intersection of GSE18686 and GSE35449 SOCS1 IL27 TAP1 GPX3 GBP4 MT1G PSME2 CYP27A1 LPL TNFAIP6 MT1A APOC1 STAT2 IFITM1 AIM2 IRF1 IRF7 RSAD2 CXCL10 SCARB1 LAP3 CRABP2 MT1E IFI27 CCL8 IFIT3 IFIH1 IFIT2 ANKRD22 CYBRD1 NCF1 IFI44L ISG20 SLAMF7 HLA-F IL18 ISG15 ZNFX1 GBP2 PARP14 LGALS3BP BATF2 TLR5 PTGS2 GBP1 IL6 XAF1 MT2A IDO1 ETV7 STAT4 ENPP2 PMC7998878__F3 TRIM8, NFKB and JAK-STAT pathways IFNG STAT3 TNIP3 TRIM8 PMC4859898__F4 mTOR signaling pathway regulated by CDDO-Me in Ec109 cells RHEB TSC2 EIF4B RICTOR PC MTOR ELF3 EIF4E PMC6172368__F5 Sub-networks constructed based on the differentially expressed genes identified in the communities of interest in the protein-protein interaction network using CFinder software SOCS1 IFIT3 TRIM2 MYD88 GBP4 ISG20 CLEC4A IL18 TLR7 GBP2 CD209 PARP14 CD14 BATF2 IRF1 GBP1 IL6 XAF1 AQP9 LAP3 FGL2 CD1C IFI27 TNFSF10 CYBB PMC6235888__F6 Schematic pathway summarizing the manipulation of GAL via the activation of A7 nAChR to mediate its anti-inflammatory effect HMGB1 GAL RELA SOCS3 PMC7247338__F3 Proposed miRNA–mRNA interaction network of the 10 most abundant differentially expressed miRNAs (DEMs) with their potential target mRNAs KLF4 KIF26A FAF1 PPP3CA MYT1 MEF2C KCNK10 CCDC43 CCDC171 FXR1 E2F3 MYO1C ROCK1 MYH9 MAML2 ULK2 BMPR2 DYRK2 MAP4K3 CDC73 IGF2BP3 MYH10 ATG14 ELF2 HEL70 EIF5 FOS EIF4E MBNL1 MYT1L PDLIM3 DKFZp666G145 P4HA1 MMD SP5 PMC9332480__F4 Multifunctional Role of S100 Protein Family in the Immune System: An Update CCL3 CCL4 CCL2 MPO PMC11624271__F2 General signaling pathway of CLRs from Dectin-1 and Dectin-2 clusters SYK CLEC9A BTK RAF1 BCL10 CARD9 PMC4790585__F1 Wnt/Beta-catenin canonical pathway DVL1 ROCK2 APC GSK3B DVL2 ARHA DAAM2 RAC1 CTNNB1 BCL9 DVL3 NLK LEF1 DAAM1 PMC9133079__F3 Signaling events evoked by domain III of envelop glycoprotein of tick-borne encephalitis virus and West Nile virus in human brain microvascular endothelial cells SOCS1 STAT3 AXL STAT2 JAK3 SOCS3 ITGAV RAC1 MERTK STAT1 TYRO3 IFNAR2 PPP2R1B IFNAR1 CLEC2D STAT4 IFNB1 JAK1 PMC4790585__F2 Wnt cross talk BAX EGF BAD EGFR GSK3B PTEN MDM2 MTOR GAB2 CTNNB1 PMC12032345__F1 STING signaling pathwayDNA from damaged mitochondria or pathogens can be recognized by cGAS, and cGAS subsequently catalyzes the formation of 2′,3′-cGAMP TBK1 ADA2 CGAS IRF3 IL6 TREX1 DNASE2 TNF ENPP1 PMC6771394__F6 Allelic origins of the carotenoid pathway genes TH tmp_locus_29 FOS PMC8099721__F1 Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11 HEL-S-31 FAM83B LIN28A RAB14 CCNJ CMTM3 CXCR4 KRAS FLRT3 PMC6587955__F1 BMPR signaling BMPR2 ACVR2B ACVR2A ACVR1 SMAD6 RHO ID1 ID3 PMC3065765__F3 Iron in regulating the mTOR signaling pathway RHEB TSC2 RICTOR TSC1 PDPK1 DDIT4 PRH PTEN PMC4539557__F9 This cartoon summarizes our observations and integrates them into the context of previous studies SERP2 BMP4 SHH CTNNB1 PMC12040678__F5 Pathogenesis of HMGB1 in alopecia areata HMGB1 TLR4 LRP6 PMC11853802__F2 Schematic diagram summarizing the possible involvement of the GnIH system in endocrine axes and peripheral regulation TH TRH CRH GC POMC NPY PMC8238245__F1 Action of PLK inhibition PLK3 PLK2 PLK4 MTOR PMC12001862__F9 Protective function of DHM on renal oxidative stress, inflammation, and mitochondrial-induced apoptosis by regulating the EGFR/HSP27/STAT3 signaling pathway in CP-induced AKI STAT3 BAX EGFR PMC9166579__F8 Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/Beta-catenin signaling pathway in mice DKK3 IGF1 APC GSK3B LRP5 LRP6 IGF1R CTNNB1 PMC4207242__F1 Pathways Modulating GLI1-expression/activity in Cancer EGF TGFB1 EGFR SHH BCL2 SMO KRAS PMC4344387__F1 Wnt/Beta-catenin and Notch signaling pathways and pathway crosstalk as illustrated herein APC GSKIP GSK3B RBPJ PMC7079523__F8 Pathway and temporal expressional patterns of oil accumulation LPA PDC PC PMC2526691__F2 Focal adhesion pathway interaction map HEL-S-11 PMC3063577__F2 Simplified diagram showing some of the identified BCR pathway members SYK BTK FYN CD72 PLCG2 BLNK LYN DOK3 MTOR BIK LCK PMC6597102__F2 Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation CDH2 LTA LTBR GDNF APOE SHH CXCL10 BDNF CCL2 IL1B CTNNB1 PMC8024566__F1 CCR7 and the reactive LN CCL19 CXCL13 BCR CCL21 CCR7 CXCR5 PMC5727251__F4 Inhibitors of the FZD/LRP/Wnt signalling cascade SOST NOTUM LRP5 PMC2691779__F1 Schematic overview of the human tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) apoptosis pathway ATM DIABLO FADD PMC6815304__F3 The principal signaling events occurring during fluid shear stress in bone cells CDH2 SOST GSK3B RHO MTOR SRC RUNX2 CTNNB1 PMC7382829__F8 Fatty acid metabolic pathways in macrophages infected with Nc-Spain1H versus non-infected cells FAS FER FBL FASN FES PMC7708060__F1 Cellular pathways for DNA double-strand break repair RAD52 RAD51 BRCA1 PAXX BRCA2 BLM PARP1 PMC7382829__F6 KEGG pathway maps represent the NF-ƙB signalling pathway in which DEG in (a) bovine macrophages infected with Nc-Spain1H and (b) Nc-Spain7 versus non-infected macrophages are highlighted IL19 SYK LTA LTBR TRADD TIRAP LAT TRAF3 TRAF6 DAO NGF PLCG1 BTK COX2 BCR TLR4 ATM IL1B CD14 BLNK PARP1 LTB CNTF TRIM25 LYN LBP TRAF2 LCK PMC9421435__F4 Role and Therapeutic Potential of Macropinocytosis in Cancer TPM1 CXCL1 IL6 CCL5 PMC10774482__F1 Canonical signaling pathways of cGAS TBK1 CGAS IRF3 PMC3247754__F3 Simplified view of the glucose sensing mechanisms in S NRG1 TSTD1 TPK1 PDE12 OTP PMC7544984__F6 Crosstalk between SRSF3 and other splicing regulators in the regulation of gene expression HNRNPL SFRS3 PMC4503753__F7 EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer CD44 EPCAM SOX2 FHL2 BCL2 CTNNB1 PMC4979999__F6 Exercise Activates p53 and Negatively Regulates IGF-1 Pathway in Epidermis within a Skin Cancer Model IGF1 PTEN IGF1R MDM2 PMC5302553__F2 Efferocytosis in Atherosclerosis HEL-S-99n IL10 GAS APOE ABCA1 CD47 MERTK PMC3833078__F3 In addition to apoptosis, AR may also regulate other kinds of cell death ACD RHO PMC9157596__F4 Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes PPARG PIK3CA STK11 CREB3 APPL1 PIK3R3 PIK3CD PIK3R2 RPS6KB2 PIK3R1 PRKAG2 ATF2 MTOR PRKAA1 CREB3L2 ADCY9 INSR RB1CC1 KL CAMK4 ATF4 ADCY6 CREB1 RPTOR BAX ADIPOR1 EIF4EBP1 ADIPOR2 KRAS IRS1 EIF4E HRAS RHEB ATF6B TSC1 ADCY3 FOXO1 FOXO3A PRKAA2 PRKAG1 SESN3 PRKAB2 PRKAB1 ADCY1 SESN1 SESN2 PMC7401857__F10 Pro-inflammatory signaling molecules release upon HMGB1 stimulation and its receptor blocking HMGB1 TLR4 PMC4043871__F2 Testosterone signaling pathways in Sertoli cells EGFR SRC PMC9674421__F11 Expression and Prognostic Significance of PDIA3 in Cervical Cancer SVIP BAX UBC UBE2G2 SKP1 ATF4 PMC9642324__F1 Immunomodulators: still having a role? NUDT15 RAC1 TPMT PMC8538681__F1 Nucleotide Pool Imbalance and Antibody Gene Diversification PNP NDP ADA PMC5962346__F1 Molecular targets for therapy in the HH pathway web of collaboration LATS1 LPA EGF CCNE1 HHIP SUFU SMO MTOR TNF CCND1 PMC8421901__F3 Underlying mechanism of sorafenib resistance in hepatocellular carcinoma: a bioinformatics study based on validated resistance-related genes MAX RAN COMP MAL KL APP PMC8269379__F1 New Paradigm in the Relationship between Melatonin and Breast Cancer: Gut Microbiota Identified as a Potential Regulatory Agent AANAT AHR ASMT CYP1B1 PMC5559174__F8 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome NBR1 LAMP2 ATG3 WDFY3 ATG16L1 ATG12 BCL2 SQSTM1 MTOR STX17 ATG5 PMC12040678__F2 Pathogenesis of HMGB1 in vitiligo CD80 HMGB1 CXCR6 TLR4 CXCL16 PMC11959080__F2 Subcellular localization and proposed molecular mechanisms of ZNFX1 MAVS NLRP3 ZNFX1 PMC12040678__F3 Pathogenesis of HMGB1 in psoriasis CD80 HMGB1 TLR4 IL23R PMC5559174__F7 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome MAX ATR BAD FAS CYCS TCF4 RHO MYC FYN ATM MDM2 SRC CCND1 UNK BAX CD2 IRS1 RBL1 CRK TCF3 CBL BRCA1 FOXO1 SUFU BCL2 LEF1 FADD PMC5559174__F4 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome PPARG SIRT7 NDUFA9 CYCS HIF1A SIRT2 TUBA1B CTNNB1 RB1 SIRT3 RARA DCP2 RARB HSF1 IDE TUBA1A HCRTR2 SIRT4 RBL2 TUBA1C PARP1 SDHA RBL1 TSC2 FOXO3A SLC25A6 ACADL SIRT1 PMC3375679__F2 Environmental regulation of GSC proliferation at developmental stages of the gonad AAK1 NOS2 VRK1 GSC PTEN GAS1 PMC5559174__F5 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome HMGB1 JUN PPIB SELE CASP12 EPO MIF BLM FTL MRE11A INSR HOXA10 MAF ATM ATF4 VCAM1 GRB2 LPP CP UNK UBB PMC5559174__F2 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome RPS6 EIF4B MTOR RHO EIF4E RHEB TSC2 RICTOR TSC1 INSR RS1 PC ELF3 PMC5559174__F3 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome CD40 ZAP70 EGF LTA TGFA LTBR TRADD TIRAP CARD11 RELB TAB3 GSK3B TANK TRAF6 MYD88 NGF PLCG2 TBP HDAC1 UBE2V1 HEL-S-71 MAP3K7IP1 TRAF2 FADD LCK PMC4790585__F7 General role of the proteins used for in silico experiments APC NKD2 GSK3B CTNNB1 PMC5487560__F1 The kynurenine pathway of tryptophan degradation HEL-S-90n KYNU KMO HAAO PMC8722298__F2 Small extracellular vesicles: from mediating cancer cell metastasis to therapeutic value in pancreatic cancer BTG2 TGFBR3 TSPAN8 PMC4382495__F2 Signaling pathways involved in thyroid carcinogenesis and tumor progression BAD BRAF MTOR CCND1 CTNNB1 PMC7848457__F9 Proposed model of molecular targets of NSAIDs in enhancing Hsp90 inhibitor cytotoxicity of CD44highK562 cells CD44 STAT3 HSF1 MTOR PMC6413549__F4 Biochemical process networks of the differentially expressed proteins generated by MetaCore™ software using a transcription regulation algorithm LPL DNAJB1 HEL-S-94n PABPC1 PSMC4 PROX1 HEL-S-99n TXN DNAJC3 PSMC6 YWHAQ HEL-S-102 DNAJB11 HEL-S-1 DNAJA2 PMC6613304__F5 Nicotinamide Adenine Dinucleotide (NAD+) Biosynthetic Pathways NMRK1 HEL-S-90n NMNAT1 NADK NAMPT NMNAT2 NMRK2 NMNAT3 PMC5802197__F3 CAD backbone network PIK3CA EDN2 PIK3R1 NRP1 UCP1 HIF1A MYC LRIG1 EREG SOST FLT4 FGFR1 BTC POMC MMP2 MMP3 NPY KDR UBB HEL-S-44 NOS2 SP1 ANGPT2 TSLP GFAP tal-1 SAFB VEGFC TGFA TGFB1 LEP XBP1 MPO THRA LCOR CBLC IL18 AHR CEBPB MUC13 THBS1 KRAS IGF2 CBL EPN1 RS1 EP300 SNX1 CD40 PPARG SHC1 OSM VAV2 RGS16 TRIM2 GHRL NR0B2 IAPP TFF1 TRIM24 DCN SMARCA4 CSF2 ADM CRKL VEGFA FOS NR2F1 HRAS CRK ENG GRB2 SDC3 EGF MMP14 HGF EGFR VTN MTOR NCK2 INS TRRAP RARA RETN NR3A2 ELANE NR1A2 JUP CRP TNK2 UBC JUN GPC1 LIF NRP2 PTPN11 IL6 ESRRA CD44 SPRY2 NCOR2 CNTF NRG1 PRL RELA SIRPA JAK1 STAM2 IL23A PF4 PMC6542018__F1 Estrogen receptor (ER) activity in breast cancer - canonical (classical; ligand-mediated) and non-canonical (alternative; ligand-independent) pathways of ER activation FOXA1 FGF7 NFIB FGFR1 FGF5C YBX1 FGF10 FGFR2 PMC8722298__F1 Small extracellular vesicles: from mediating cancer cell metastasis to therapeutic value in pancreatic cancer ACTA2 LIN28B HMGA2 CMTM4 PMC12208402__F12 Proposed RasV12 singling network leading to cell dissemination RHO RAC1 PMC3110938__F2 Genome-wide dissection of microRNA functions and co-targeting networks using gene-set signatures CDC42 PREX1 HGF IGF1 CREB5 INSR PTPN1 RHO MTOR INS RAC1 PMC7018661__F6 The epithelial–stromal interactions in the tumor microenvironment of GC SP1 IL33 ZEB2 PMC4741792__F6 GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells CXCL12 LCP1 CXCR4 PMC8374895__F9 miR-200a-3p Attenuates Coronary Microembolization-Induced Myocardial Injury in Rats by Inhibiting TXNIP/NLRP3-Mediated Cardiomyocyte Pyroptosis GSDMD NLRP3 TXNIP PMC9408967__F9 Dentin Particulate for Bone Regeneration: An In Vitro Study MSX1 APC RUNX2 CTNNB1 PMC8610981__F1 Evaluation of selected IL6/STAT3 pathway molecules and miRNA expression in chronic obstructive pulmonary disease STAT3 IL6ST PMC2896914__F2 Multiple genes involved in interferon production and regulation are associated with risk for lupus TNFAIP3 PDC TLR9 TLR8 IRF7 TLR7 TRAF6 PMC4405010__F1 Sessile serrated and traditional serrated pathways BRAF IGFBP7 KRAS MGMT PMC5760291__F10 Brucella abortus triggers a cGAS-independent STING pathway to induce host protection that involves guanylate-binding proteins and inflammasome activation NOS2 CGAS AIM2 IRF3 ARG1 IL1B PMC6391709__F5 PI3K/AKT/mTOR and ERK signalling pathways associated with cardiac hypertrophy TSC1 PTEN IRS1 PMC6449425__F1 Biosynthesis of isoprenoids in X IPP MVD MVK PMC7367500__F1 Canonical and Non-Canonical Wnt Signaling in Immune Cells CDC42 RNF43 APC LRP5 ZNRF3 LRP6 RYK ARHA GPR49 RAC1 CTNNB1 PMC6142582__F2 Targetable molecular features of primary mediastinal large B-cell lymphoma and mediastinal gray zone lymphoma SOCS1 PTPN1 CD19 REL TNF PMC4725315__F5 Ingenuity pathway analysis showing up (green) and down-regulation (red) of miRNAs involved in ovarian cancer tumor samples when compared to endometriosis samples MAP2K1 MAP2 PMC9100681__F5 Unraveling the Role of Acetic Acid Bacteria Comparing Two Acetification Profiles From Natural Raw Materials: A Quantitative Approach in Komagataeibacter europaeus FH HEL-S-162eP PDC CS PMC4014746__F1 Canonical Wnt pathway ] FRAT1 APC LRP5 TBP CCND1 CTNNB1 PMC2739756__F1 Bile acid synthesis CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC9444450__F4 Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis CDC2 RAMP2 FRS2 PNN LRRK2 EGFR HIF1A LRPPRC CAND1 FGF7 IGF1 DIAPH2 CFTR MDM2 CLTC CDC5L TOP2A NCL PMC3204314__F7 Signalling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis SOCS3 PMC5133970__F7 Schematic representation of the proposed TCS pathogenesis model CNBP PMC10093344__F1 Innate immune signaling pathway that recognizes cytosolic DNA in tumor-infiltrating dendritic cells (TIDCs) CGAS GSDMD AIM2 IRF3 TNF PMC2739756__F3 FXR regulation of enterohepatic circulation of bile acid FGF8A NR2A1 FGFR4 DKFZp666G145 PMC2739756__F4 FXR-independent and bile acid-activated cell signaling pathways in regulation of CYP7A1 transcription NR1i1 TGFB1 HGF TLR4 CYP7A1 EGFR DKFZp666G145 IL1B PMC10093344__F3 Tumor immunosuppressive mechanism of AIM2 in TIDCs TBK1 CGAS GSDMD IL18 AIM2 IRF3 CXCL10 PMC7813598__F9 The inhibitory effect of black radish extract (BRE) in lipopolysaccharides (LPS)-stimulated RAW 264.7 cells STAT3 KEAP1 ATF4 IL1B PMC3213687__F2 Appearance frequencies of genes in the mTOR signaling pathway RHEB TSC2 EIF4B RICTOR BRAF HIF1A MTOR EIF4E PMC8746472__F3 Pharmacological Effects of Grifolin: Focusing on Anticancer Mechanisms BAX BCL2 CDK4 PMC6144698__F1 STAT3 activation pathway STAT3 CNTF EGF HGF TGFA OSM LIF SOCS3 PMC6644047__F1 Simplified TGFB signaling pathways CDK6 SMAD2 SMAD4 CDK2 NODAL ARHA MTOR MYC CDK4 PMC3943571__F1 Ras signal transduction CS MTOR PMC8797453__F5 KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer MSRA KRAS HEL2 PMC8277821__F8 Schematic diagram of miR-301a-3p based signalling circuit of trastuzumab resistance in HER2-positive GC LRIG1 FGFR1 IGF1R PMC6584407__F7 Signaling mechanism of MUS81 and CyclinB CDC2 ATR RAD50 RAD51 MRE11A ATM BLM EME1 PMC5922678__F1 Alterations in the steroid biosynthesis pathway in congenital adrenal hyperplasia (CAH) HSD3B2 CYP21A2 CYP17A1 CYP11B2 CYP11A1 HSD3B1 PMC9110871__F3 Viral and cellular translation during SARS‐CoV‐2 infection TBK1 STAT1 TLR3 STAT2 IFNAR2 IRF9 IFNAR1 NXT1 IRF3 IRF7 TRAF3 JAK1 PMC7855940__F1 Multifunctional APE1 DNA repair–redox signaling protein as a drug target in human disease PNKP STAT3 FEN1 PCNA HIF1A IL1A PMC9209555__F3 Targeted Sequencing Identifies the Genetic Variants Associated with High-altitude Polycythemia in the Tibetan Population TCL1A EPOR EPO RELN PMC8953329__F1 An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications NHS GLA CIT PMC6759660__F2 Different ncRNAs regulate PDCD4 in mutiple ways CDK6 MAP4K1 EZH2 CDK4 CTNNB1 PMC6896012__F1 The KEGG calcium signaling pathway TRDN PLN CAV2 HRC BCR MCU DAO PMC6524680__F6 PDGF effects in periosteum derived progenitor cells and its interaction with BMP2/Smad signaling SMAD1 DKFZp781O1323 PDGFRA PMC3578923__F8 Global Analysis of the Human Pathophenotypic Similarity Gene Network Merges Disease Module Components IVD ASL PCCA DBT OTC DLD ACADM PMC8742263__F2 Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation SMAD1 SOST DKFZp781O1323 RUNX2 CTNNB1 PMC7982967__F2 Mechanistic actions of Ca2+ during myofibroblast differentiation TGFBR2 TRPM7 COL1A1 TRPC6 TRPC3 TGFBR1 PMC4742785__F4 Working model of an integrated axon degeneration signaling cascade SARM1 ZNRF1 NMNAT2 PMC5318464__F1 Diagram of immune responses induced by Leptospira sp NLRP3 IL16 TLR4 CD14 MYD88 PMC4510916__F2 Lf intervention upregulates the neurotrophin-signaling pathway in postnatal piglets CRK NGF BAD FRS2 MAPKAPK2 GSK3B BDNF PMC1817805__F2 AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer TSC2 FAS MTOR PMC6821213__F8 FAE therapy modifies the metabolic-epigenetic interplay in multiple sclerosis to reduce pathogenic CCR6+ CD4 and CD8 T cells CCR6 PMC8699029__F1 System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach STAT3 NR1C1 LEP TRADD POMC NPY SOCS3 AgRP MTOR TNF TRAF2 PMC8877377__F1 High Expression of Interferon Pathway Genes CXCL10 and STAT2 Is Associated with Activated T-Cell Signature and Better Outcome of Oral Cancer Patients STAT2 CXCL10 SET PMC2878924__F6 Two models for coupling the circadian clock to the cell cycle/checkpoint response XPA ATR ATRIP WEE1 ATM PMC3901112__F1 Autophagy is initiated by stimuli that activate the phosphatidylinositol 3-phosphate kinase, Vps34 ATG3 ATG12 ATF4 EIF2A ATG5 PMC2878924__F5 DNA damage checkpoint pathways HUS1 TOPBP1 ATR RAD50 ATRIP RAD1 MRE11A BRCA1 CDC45 RAD17 ATM MDC1 PMC6039551__F3 MicroRNAs (miRNAs) regulate innate host immune response against influenza infection by targeting intracellular signaling pathways TBK1 MAVS TLR3 TLR4 TLR8 IRF3 IRF7 TLR7 TRAF3 TRAF6 S100A9 PMC8578384__F3 Candidate genes of SARS-CoV-2 gender susceptibility TMPRSS2 HMGB1 GATA1 CCL11 SERPING1 TLR9 IRF3 ENPEP TLR4 GC ADAM10 CCL4 TLR7 ACE2 PMC7392272__F2 Identifying the key regulators that promote cell-cycle activity in the hearts of early neonatal pigs after myocardial injury DVL1 RASSF6 SMAD1 TP53BP2 RASSF1 SMAD2 GSK3B FBXW11 SMAD4 FRMD1 MYC APC2 TEAD4 CTNNB1 LATS1 MOB1A FRMD6 MOBKL1A WWTR1 LATS2 LIMD1 BTRC AFP TEAD2 CSNK1E TEAD3 NF2 CCND1 ACTG1 SNAI2 CSNK1D APC SOX2 DVL2 AXIN2 YAP1 AXIN1 DVL3 AJUBA PS1TP5BP1 PMC9204329__F1 Of DEK proto-oncogene as a prognostic biomarker for colorectal cancer: An evidence-based review BAX DEK CTNNB1 PMC5372848__F1 Activation of the RAS/ERK and phosphoinositide cell signaling pathways following the binding of cell survival signals to receptor tyrosine kinases (RTK) TSC2 TSC1 PTEN PMC8508836__F7 Survival Motor Neuron Gene Expression by Calcium Signaling SRSF9 TG CAMK4 PMC2805009__F1 Cross-talk between TCR and TGFB signaling networks JUN SMAD2 SMAD4 IL2RA FOXP3 FOS PMC3445581__F2 Transcriptional Differences between Rhesus Embryonic Stem Cells Generated from In Vitro and In Vivo Derived Embryos STAT3 CXCL12 CITED2 SP1 SMAD2 EDN1 SMAD4 MDM2 VEGFA MYC STC1 FGF2 PMC9442310__F7 miRNAs‐mediated control of MOV10 expression regulates L1 retrotransposition in mESCs MOV10 DGCR8 DROSHA PMC6283569__F6 E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling IGF1 IRS1 PMC2928541__F2 Wnt signaling pathway GSK3A APC CTNNB1 PMC11016262__F2 Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis NOD2 NOD1 PMC11899224__F10 Effect of BBR on NLRP3 inflammasome pathway and TLR7/NFKB pathway GSDMD NLRP3 TLR7 IL1B MYD88 PMC11016262__F3 Immune cells along the gut-lung axis IL25 MADCAM1 IL33 PMC8151866__F1 BANK1 in B Cell Signaling and Disease BLK BCR BANK1 IRF7 TLR7 LYN SRC TRAF6 CYLD AID MYD88 PMC5101451__F1 Signaling pathways of TLRs TBK1 TIRAP TAB3 TLR9 IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR7 PMC5506042__F6 Number of genes including those downstream of HIF-1 signaling pathway were up-regulated in the pancreas in response to HFD TIMP3 TGFBI HEL-S-62p TIMP4 NRP1 BNIP3 TGFBR3 TGFBR2 WT1 ANGPTL4 BTG1 SERPINE2 CDKN1A PTGIS CDKN1B BCL2 TIPARP KDR IMPACT PMC6988017__F3 PPI network analysis KLF4 THY1 F5 CTHRC1 IBSP ALDH2 HLA-DRA CD74 TYROBP ECHDC2 WAS PLOD2 CYBA ABLIM1 HLA-DMB VWF SLAMF8 SMOC2 OPA1 PLAUR ARHGAP30 SERPINA1 CXCL16 CD14 SPTBN1 NCF4 LPAR1 MMP9 SPP1 RHOU PLCE1 HLA-DMA CCL19 FOXO1 RHOB VCAM1 PMC7300300__F3 Schematic illustration of the intervened network with Gegen Qinlian Decoction (GQD) based on ingenuity pathway analysis (IPA) LPL PPARG ACOX1 SLC2A4 GFPT1 ACACA ACADM ACACB NR1C1 THRSP HEL-S-162eP ACADL PPARGC1A PMC3004666__F1 Cetuximab in the treatment of colorectal cancer EGF BAD PTEN IGF1R MTOR PMC7332664__F1 Cores of the HIF pathway and the Hippo pathway LATS1 LATS2 VHL PMC8617980__F1 Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose? PNP ADK ADA PMC8617980__F2 Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose? PMC8617980__F3 Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose? BTK ABCC6 NAT8L PMC4159007__F8 Epigenetics and the Evolution of Darwin’s Finches CD40 TIRAP PARL STAC CTSK CD14 LBP IRAK4 CD6 FADD PMC5429547__F3 Differentiation of naïve Th cells into Th2 cells IL25 CD80 IL33 CTLA4 GATA3 PMC4159007__F9 Epigenetics and the Evolution of Darwin’s Finches DCT CTNNB1 PMC10981339__F3 Anti-inflammatory effects of SIRT in IVDD TLR4 RELA SUV39H1 SIRT1 SIRT6 PMC4159007__F7 Epigenetics and the Evolution of Darwin’s Finches IFNG FST SKP1 ARHA TNF PMC10187169__F2 Pathways included in the model RHEB TSC2 NRP1 PTEN SRC HES1 VHL PMC4306671__F3 Pathway enrichment results: (A) hsa05200 (pathway in cancer); (B) hsa05218 (melanoma) VIT BAD BRAF KIT PTEN MDM2 CDK4 PMC11808223__F1 Intestinal changes in T2DM IFNG PYY IL1B MYD88 PMC5384647__F10 An ID2-dependent mechanism for VHL inactivation in cancer ID2 VHL PMC8297547__F1 Protein Kinase R in Bacterial Infections: Friend or Foe? NLRC4 NLRP1 NLRP3 AIM2 IRF3 ATF4 ATF2 EIF2A IL1B FADD PMC8463317__F4 lncRNA and breast cancer: Progress from identifying mechanisms to challenges and opportunities of clinical treatment DNMT3B CDK6 CDK2 EZH2 PTEN MTOR MYD88 PMC7835797__F1 Epigenetic Alterations in Renal Cell Cancer With TKIs Resistance: From Mechanisms to Clinical Applications SMYD2 HGF AXL QPCT EZH2 PTEN ZEB2 MTOR SOX5 CTNNB1 PMC8422929__F1 Regulators of liver cancer stem cells KLF4 STAT3 HGF TP53INP1 SOX2 AXIN1 TBX3 SETD2 PMC8832957__F2 Tumorigenic bacteria in colorectal cancer: mechanisms and treatments MAX RAD51 COX2 RNF168 TLR4 HEL-S-11 PMC5332411__F3 IFN pathway of elephant shark IRF9 SOCS4 SOCS2 IRF3 IRF7 SOCS3 IRF4 IRF8 PIAS2 IRF6 IFNAR2 IRF2 PIAS1 PMC3747328__F1 The role of K+ channels during cell cycle progression and proliferation CDC2 TF JUN MPZ ORAI1 TRPC1 FOS ORAI3 IGF1 CDK2 TRPV6 UNK CDK4 PMC6144355__F1 Molecular mechanisms of TNBC ETS2 AXL EGFR APC SMAD4 PTEN MTOR MYC CTNNB1 PMC6202827__F7 IL-1B signaling pathway in CXCR3-mediated MSC transendothelial migration CXCL9 CXCR3 MSC IL1B PMC4779832__F4 Cross talk between ROS and Keap1-Nrf2-ARE signaling pathway NEDD8 FYN PRX HEL-S-64p PMC4779832__F2 Cross talk between ROS and NFKB signaling pathway NEDD8 RELA RELB PMC4779832__F3 Cross talk between ROS and MAPKs signaling pathway STAT1 ATF2 GRB2 MEF2C MEF2D PMC5971010__F1 Admixture Mapping Links RACGAP1 Regulation to Prostate Cancer in African Americans NRARP ADAM10 PMC8999833__F3 Candidate Genes and Pathways in Rice Co-Responding to Drought and Salt Identified by gcHap Network ADM HAP1 PMC7404102__F1 SARS-CoV(-2) host cell infection, replication (Phase I) and induction of immune response (Phase II) TMPRSS2 APC IL6 ACE2 PMC6888566__F1 Wnt signal transduction LRP4 RNF43 APC GSK3B LRP5 ZNRF3 LRP6 ARHA GPR49 CTNNB1 PMC7284145__F7 Biological pathway related to TMPRSS2 predicted by KEGG TF TMPRSS2 ETV5 SPINT1 IL1R2 PLAT ETV4 ERG PMC9368248__F6 Molecular Regulation of Yak Preadipocyte Differentiation and Proliferation by LncFAM200B and ceRNA Regulatory Network Analysis CDC20 PML NUMB HES1 HES5 PMC196255__F1A Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway IRS4 PTEN MTOR IRS1 PMC6888566__F4 Roles of non-canonical Wnt pathways in osteoclast differentiation and function DCSTAMP JUN WNT16 SP1 ROR2 PKN3 NFATC1 WNT4 DAAM2 RHO PMC5751354__F4A Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance HEL-S-133P HEL-S-26 PMC6032409__F3 Signaling pathway that results in the production of tumor necrosis factor alpha (TNFA) in macrophages after the stimulation by lead and lipopolysaccharide (LPS) TLR4 CD14 MYD88 PMC5786553__F1 Fatty acid synthesis in Mortierella alpina tmp_locus_29 FADS6 GLA FADS1 TNLG7C PMC4942776__F6 Profiling of Host Cell Response to Successive Canine Parvovirus Infection Based on Kinetic Proteomic Change Identification SUMO2 CFTR AMFR SAE1 PMC4916003__F1 Natural products as TLR agonists and antagonists affecting various stages in the signaling pathway, including downstream molecules MyD88 and IKK TLR1 TLR4 TLR9 TRAF6 PMC7278058__F6 Pathway modeling CALD1 INMT PNMT APC CXCL10 NCF1 CTNNB1 KIF7 SUFU RELA SHH BCL2 SMO TRAF2 BIK PMC3939471__F1 Involvement of CD81 in Hepatitis C Virus (HCV) lifecycle HRAS CD81 NPC1L1 EGFR LDLR TNF CD63 CLDN1 PMC7107758__F4 Resistance mechanisms to BRAF and MEK inhibitors in BRAF-V600E melanoma EGF NRG1 HGF NF1 PTEN GRB2 MTOR PMC7104317__F1 Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy TLR3 TAB3 IL18 TANK IRF3 IL6 TRAF3 TRAF6 TNF PMC6613635__F1 Simplified rationale for performing studies in NHP sepsis models of antibody inhibition of TNFA and IL-6 TF TLR4 APC F3 PLG IL6 TNF PMC4026009__F3 Network-Based Kernel Machine Test for the Identification of Risk Pathways in Genome-Wide Association Studies BAD PAX4 MAFA BRAF TCF2 FOXA3 NEUROG3 INS IAPP RB1 PDX1 NR2A2 NRAS GCK MDM2 NR5A2 CCND1 HES1 PKLR CDK4 NEUROD1 SLC2A2 PAX6 ONECUT1 NR2A1 CDKN1A FOXA2 HNF1A PMC7999907__F1 Degradation of p53 induced by E6 variants of human papillomavirus (HPV) 16 favors metabolic reprogramming INSR HK2 TIGAR PMC3249681__F8 Simplified diagram depicting the proposed signaling pathway of the CB1 activation that inhibits the activity of small GTPase RhoA to inhibit motility of PC-3 cells CDC42 ARHA RAC1 PMC7999907__F3 Metabolic reprogramming is mediated by HPV 16 E6 variants through c-Myc, hypoxia-inducible factor (HIF)-1A, WNT, and miR-21 STAT3 PPARGC1B HEL-S-133P CD36 APC FASN CTNNB1 VHL PMC7466715__F3 Signaling pathways of TGFB and Wnt involved in joint pathophysiology SMAD1 DKFZp781O1323 SMAD2 LRP5 CTNNB1 PMC5943339__F3 Top networks of differentially expressed genes in PTvs.N as identified by Ingenuity Pathway Analysis show strong association to cancer and connective tissue disorders CEACAM1 DGIC SPARC SPRR3 BLNK EHF Nucb2 POSTN LOX MUC5B GALNT12 F3 MMP3 SULF1 CEACAM7 GCNT3 MUC7 PRSS2 RHCG TCN1 KRT13 STATH PMC5943339__F4 Top networks of differentially expressed genes in Mvs.PT as identified by Ingenuity Pathway Analysis show strong association to cancer and connective tissue disorders HEL-S-117 CD3D KLF2 ZMIZ1 DSC3 EVPL ETHE1 MAP2 IRF8 MYC CDC42EP3 ADH1A ERF GTSE1 CEBPA CPNE7 CTDSP1 CDR2 TPP2 MAP2K1 CORO1A TADA2B RAB25 ZNF385B PMC6059749__F11 miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer (NSCLC) through PD-L1 expression via the PTEN pathway IFNGR2 IFNGR1 CCR4 PTEN PMC7868342__F11 Signaling pathways involved in rhFGF20-mediated protection against BBB disruption both in vivo in TBI mice and an in vitro in a TNF-Alpha-induced HBMEC model GSK3B IL1B PMC3849582__F1 Network Diagram of the single C RPS3 AQP9 EP300 PMC8467361__F2 Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point ULK1 MTOR SIRT1 PMC6336830__F3 Summary of the mechanisms involved in the stimulation of brown adipogenesis, mitochondrial biogenesis and energy expenditure by some dietary molecules ADRB3 NR1C1 PRDM16 TRPV1 UCP1 TRPM8 PMC6184651__F7 ECM-receptor interaction pathway, (b) focal adhesion pathway, (c) regulation of actin cytoskeleton pathway, (d) TGFB signaling pathway TH BAG1 HEL-S-28 PTEN PMC8582887__F2 PI3KD Inhibitors as Immunomodulatory Agents for the Treatment of Lymphoma Patients IFNG RPS6 BACH2 SELL FOXO1 CCR7 PTEN FOXP3 PMC9156734__F3 Roles of different molecules related to the PI3K/AKT pathway in CECs in diseases and therapeutic strategies BAX EGF HMGB1 HGF HMGA2 IGF1 IL16 TFEB IGF1R SRC SIRT1 PMC9156734__F4 Localization and function of different molecules involved in the PI3K/AKT signalling pathway in the CE HGF IGF1 PMC7643595__F1 Revisiting the Bacterial Phylum Composition in Metabolic Diseases Focused on Host Energy Metabolism NR1C1 CCK PYY PMC9156734__F2 PI3K/AKT signalling pathway in CECs RPS6 BAX EGF BAD PCNA PXN TRPV1 EIF5A PTEN IGF1R MYC TSC2 IGF1 INSR SRC PMC4931961__F3 TNFA Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB MADD CD40 TBK1 TRADD EAF2 TANK TNF FOS STRAP FADD PMC12080927__F6 Distribution of targets in the MAPK signaling pathway MAX ECSIT EGF FAS CD14 GRB2 NLK TNF FLNA TRAF2 MEF2C PMC3692130__F1 Graphical representation of Wnt pathway as described in the KEGG repository () DVL1 FZD10 ELL FBXW11 NR1C2 MYC PORCN DKK1 CTBP1 SENP2 CACYBP NKD1 SOX17 MMP7 JUN SIAH1 TBL1X ARHA RBX1 CXXC4 CTNNBIP1 PLCB1 CER1 NLK WIF1 PMC6423135__F5 Pathway scheme with marked involved proteins JUN BAD FRS2 ARHA GRB2 SHE TRAF6 AEN RAC1 PMC3198763__F2 MTORC1 pathway controls cellular metabolism ACLY HEL107 AGPAT5 ACSL3 GLS GDPD1 HK2 FASN FADS2 MVK HSD17B12 HMGCS1 HMGCR PFKP HEL-S-49 PGM2 HEL-S-162eP SLC25A1 ENO1 HEL-S-87p PMC8958887__F7 M6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma STAT3 SOX6 WTAP METTL14 IL6 METTL3 IGF2BP2 CTNNB1 PMC5125896__F1 Biosynthesis, remodeling and turnover of mitochondrial cardiolipin LPA PGS1 AGPAT5 PGP PMC8541410__F2 An Update on Innate Immune Responses during SARS-CoV-2 Infection TBK1 MAVS STAT2 IRF9 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 STAT1 NLRP3 TLR3 IFNAR2 TLR4 IFNAR1 TLR7 JAK1 TYK2 PMC11757636__F3 Influence of autophagy on the progression of pneumoconiosis FAS TLR4 MTOR ZC3H4 PMC11757636__F4 Influences of apoptosis and pyroptosis on the progression of pneumoconiosis BAX FAS GSDMD NLRP3 EIF2A PMC9571513__F7 Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway KEAP1 GPX4 PMC8748174__F1 Roles, molecular mechanisms, and signaling pathways of TMEMs in neurological diseases BAX PCNA CDK2 BCL2 VCAM1 CDK4 PMC8000702__F4 C-Peptide as a Therapy for Type 1 Diabetes Mellitus VWF AGER GPX1 IL1B PMC4933106__F1 Role of reactive oxygen species in age‐related neuromuscular deficits TF HSF1 PRX PMC2881367__F7 CircleMap display of the ErbB2 pathway ERBB3 NRG2 ERBB2 MTOR PMC4500525__F1 Mammalian inositol phosphate metabolism ITPK1 CSA2 PTEN PMC8136122__F7 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) FAS PMC6562018__F2 Reduction in AAs (EAAs, BCAAs, and Met) induces uncharged tRNA and activates GCN2, eIF2A and ATF4/5, resulting in increased FGF21 production HEL-S-182mP IGF1 ATF4 PMC7533008__F4 Underlying glucometabolic mechanisms on pyruvate protection against diabetic nephropathy ATP8 PMC7076852__F7 Summary diagram of the proposed mechanisms underlying protective effects of C3G against glutamate-induced oxidative/ER stress apoptosis in HT22 cells ELL PMC2964046__F1 Currently-known relationships among genes analyzed based on manually curated examination of the published literature within the Ingenuity Pathway Analysis® Knowledge Base ACLY PPARG TGFB1 DGAT1 CD36 HEL-S-62p LYZ ACACA MTOR MYC FADS1 CTSC GPX1 INSIG1 TGFBR1 PIGT BTN1A1 LYZG F2R CSNK2A2 DGAT2 MUC1 MMP2 CSN3 EEF1A1 ABCG2 FSTL3 S100A10 SCD FASN SREBF2 TNF CAPNS1 ACSL1 THRSP IGFBP5 HEL110 XDH ADFP HP CSN2 PMC5514720__F2 Transcriptomic analysis of HBCs reveals that the Notch pathway is differentially regulated during activation from dormancy DLL4 JAG2 NUMB NOTCH2 NOTCH3 DLL3 NOTCH1 PMC7474159__F9 New concept based on this study PDGFRA PMC7027016__F4 Histone methylation plays a role in hypertension, aortic dissection, and pulmonary arterial hypertension EZH2 ATG5 PMC8224166__F1 Microbial dysbiosis in carcinogenesis & cancer therapies IL13 IL6 CTNNB1 PMC3399249__F2 Interactions between cytokine and glucocorticoid receptor (GR) signaling pathways STAT3 STAT1 JAK1 FOS TYK2 PMC9356167__F6 Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT/Gsk3B pathway TG GSK3B IL1B PMC9007519__F6 Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim–Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer MYB BAD RBL2 PTEN CD19 MTOR IRS1 EIF4E RHEB TSC2 BRCA1 BCR CD37 MEI1 MDM2 PMC4040986__F2 An Expanded Genomic Representation of the Phylum Cyanobacteria C6 ADK CS PMC4673013__F1 MicroRNA interactome in metabolic homeostasis TP53INP1 PMC7027016__F7 Histone methyltransferases and demethylases are involved in tumor angiogenesis DOT1L FOXM1 GATA1 SETD3 SMYD3 MMP2 EZH2 HIF1A VEGFA PMC5217345__F3 Fibroblast growth factor 21 (FGF21) regulates Sirt 1-mediated release of adiponectin from adipose tissue with relevance to NAFLD and the metabolic syndrome PGC EBP ADNP SIRT1 PMC7995212__F2 ACE2 in the second act of COVID‐19 syndrome: Peptide dysregulation and possible correction with oestrogen CSA2 ACE2 PMC9407429__F6 microRNA Expression Profile of Purified Alveolar Epithelial Type II Cells MAPK14 TGFBR2 BMPR2 ACVR1B ACVR1 GSC NKX2-5 TRAF6 KRAS HOXC8 RUNX2 PMC8306954__F2 Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19 NLRP3 MLKL TRAF3 TNF ACE2 PMC5406035__F5 RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection RIPK3 MAVS RIPK1 IRF3 PMC9105267__F1 CXCR4/CXCL12 Activities in the Tumor Microenvironment and Implications for Tumor Immunotherapy ZAP70 PREX1 CXCL12 APC ACKR3 SIRPA CXCR4 CD47 RAC1 PMC8841526__F8 Identification of Key Genes Related With Aspartic Acid Metabolism and Corresponding Protein Expression in Human Colon Cancer With Postoperative Prognosis and the Underlying Molecular Pathways Prediction MAX CEBPA CYP2B6 LEFTY1 ASNS ID1 PMC6018060__F2 Macrophage Phenotype in Regulating the Response to Radiation Therapy STAT3 IL13 GATA3 PMC8645898__F2 SOX9: Advances in Gynecological Malignancies SOX9 HK2 PMC7186467__F1 Targeting mitochondria for the treatment of Parkinson’s disease (PD) SDHB PINK1 PMC10573925__F1 Effect of sclerostin on the Wnt/Beta-catenin pathway APC LRP5 LRP6 CTNNB1 PMC6113920__F1 The human adrenal cortex: growth control and disorders ARMC5 AVPR1A MC2R GIPR PMC9574006__F2 Immune checkpoints in cardiovascular disease IFNG STAT3 CD80 FGL1 LAG3 PMC9495572__F1 Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s Disease BACH1 KEAP1 MAF PMC3919531__F1 The Intertwined Roles of Transcription and Repair Proteins ERCC1 XPA ATR CETN2 RAD51 PCNA H2AX BRCA2 XPC FANCD2 ATM SLX4 EME1 TDG PMC7611290__F3 REV7: Jack of many trades CDC2 RAN SIM2 CDC20 APC EZH2 TCF4 SHLD3 SHLD2 HEL-S-2a CLTA PRCC POLD2 PMC3481134__F7 PRb/E2F signaling pathway mediates three distinct arms of TGFB tumor-suppressive effects E2F4 CASP3 SMAD4 PMC12028493__F12 Proposed mechanism underlying the anti-PD effect of epicoccin A PINK1 TSC1 ATG12 PPARGC1A MTOR TUBA1B SESN2 HEL-S-64p PRKAA1 HEL-S-44 PMC6100359__F1 Insulin signalling pathway activated in retina and RB RHEB TSC2 BAD FAS CBL INSR GSK3B GRB2 MTOR INS UNK EIF4E PMC6932876__F1 Mechanisms of ADSCs differentiation into SMC and EC MED23 SMAD2 ARHA PMC2704234__F3 Immune activation induced by Beta-glucans SYK TLR4 TRAF6 CARD9 MYD88 PMC5400562__F8 Imidazoline I2 receptor inhibitor idazoxan regulates the progression of hepatic fibrosis via Akt-Nrf2-Smad2/3 signaling pathway SMAD2 NQO1 SMAD4 PMC5790215__F1 Prediction of reaction knockouts to maximize succinate production by Actinobacillus succinogenes MAL CIT PMC7767220__F4 Roles of MMPs and TIMPs in the pathogenesis of human inflammatory diseases TIMP3 MTOR IL1B PMC9180633__F1 Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma ADAM17 NRARP ADAM10 HES1 RBPJ PMC5741248__F10 Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system HEL107 STAT3 NMI UGT1A3 TGFBI ASAP1 NAMPT AKR1C1 AKR1B10 FMNL2 GLUD1 DIO1 CYP4F11 CD74 APBB1IP GCLC NDUFA3 AKR1C2 TBC1D2 NMT2 PMC5831796__F1 Hedgehog signaling pathway EVC BOC SUFU GSK3B SMO GAS1 GLI3 PMC7190864__F4 Comparison of significant canonical pathways and upstream regulators in monocytes infected or non-infected with Mtb UT127 and UT205 isolates CD40 TH HMGB1 TREM1 SELPLG OSCAR FEV CD14 CD40LG PTGS2 CS RHO TNF TXN ENG TLR4 EGR2 RET PF4 PMC12068291__F2 Graphical representation of normal functioning of Notch signaling pathway and its importance in controlling cellular and developmental processes TG CCND2 SUFU APC LRP5 LRP6 SMO PMC7190864__F5 Death Receptor Signaling pathway is illustrating inhibition of apoptosis in monocytes infected with Mtb HTRA2 ARHGDIB FAS TRADD CYCS TRAF2 DIABLO LMNA FADD PMC11356816__F9 Interactions between BAs and Other Viruses TLR4 STH PMC5831796__F4 GLI1-expressing hair follicle stem cells and their roles GPR49 CD34 PMC5794649__F2 FoxOs related signaling pathway in cancer progression and metastasis BAD SGK1 SMAD2 CDK2 PTEN ZEB2 SIRT2 CXCR4 PMC5110612__F1 Proteins with known or inferred roles in autophagy that underlie muscle pathologies in mice and humans VMA21 NBR1 LAMP2 BAG3 ATG12 BCL2 HSPB8 MTM1 ATG5 VCP LMNA PMC7327642__F8 Mechanism underlying Notch ability to promote drug resistance in multiple myeloma (MM) microenvironment ELL BCL2 CXCR4 HES1 PMC3116873__F1 Oncogenic CagA Promotes Gastric Cancer Risk via Activating ERK Signaling Pathways: A Nested Case-Control Study CRK CRKL GRB2 SRC PMC3649461__F1 Signal transduction pathways of the amino acid (AA) response (AAR) ATF4 ATF2 EIF2A PMC9114642__F1 Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury BAX BCL2 ATF4 EIF2A TRAF2 PMC9114642__F2 Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury BAX ATF4 EIF2A TRAF2 PMC3540836__F1 Experimentally supported and inferred factors of Drosophila triacylglycerol synthesis and mobilization at lipid storage droplets TG PLIN1 PC ADFP PMC7585053__F3 Graphical representation of the five candidate pathways and their significantly contributing genes HEL-S-76p DNCL1 MAPRE1 NEK2 GSK3B PLK4 CEP70 PLK1 NGF CEP63 CLTA BCAT2 AP2A1 AP2A2 POLR3B PCNT NDE1 LARS2 TBP CLTC HEL2 YWHAG GTF3C3 AP2S1 CETN2 SSNA1 EIF5 PPP2R1A TUBG1 TUBB POLR2H IARS2 AP2M1 GTF3C2 PDHA1 VARS2 BCAT1 SH3GL2 DCTN1 BDP1 PMC5356785__F1 ΔNp63A and microRNAs: leveraging the epithelial-mesenchymal transition SMAD2 GSK3B SMAD4 PTEN MTOR CTNNB1 PMC9025012__F2 Implications of Sphingolipid Metabolites in Kidney Diseases CERK SMS SGPL1 tmp_locus_29 KDSR PMC7049903__F5 Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia ACE2 PMC3093412__F1 Viperin Links Lipid Bodies To Immune Defense TLR9 IRAK1 IRF7 TLR7 TRAF6 IRAK4 MYD88 PMC9594894__F9 B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma CXCL9 IRF1 B3GALT4 MTOR CXCL10 PMC3386270__F8 IL-4 Engagement of the Type I IL-4 Receptor Complex Enhances Mouse Eosinophil Migration to Eotaxin-1 In Vitro CDC42 CCR3 RHO GRB2 SRC RAC1 PMC3116400__F1 DSBs in S and G2 phases of the cell cycle, collapsed replication forks, and daughter-strand gaps all require HR for their repair RAD50 RAD51 MRE11A BRCA1 BRCA2 PALB2 PMC3712126__F2 Bcl-2 family-regulated pathway and phenotypes in Bcl-2 knockout mice after status epilepticus BAX BAD BMF PMC7674659__F4 Mitochondrial carnitine shuttle, one-carbon folate metabolism and trans-sulfuration pathway GLDC SLC25A38 FAS CIC SFXN1 HEL-S-51e MTHFD1 SHMT1 MTHFD2L SLC25A32 HEL-S-61p CPT2 CPT1A PMC4229513__F3 Outline of the targeted therapies, which are currently available or under development for the treatment of hepatocellular carcinoma, and the molecular targets on which they are believed to act upon BAD EGFR GSK3B MTOR CTNNB1 PMC1952644__F1 Alternative signaling: cardiomyocyte B1-adrenergic receptors signal through EGFRs PLN HBEGF EGFR SRC PMC2751538__F7 Proposed VEGF-C/D cell signaling pathway to transduce LAM cell proliferation TSC2 VEGFC MTOR PMC4614397__F1 Feedback regulation of PI3K/Akt/mTORC1 signaling by Grb10 GRB10 PTEN MTOR PMC5976638__F3 The purinosome—a naturally occurring enzyme cluster? a Protein–protein interactions within the purinosome PAICS HEL-S-70p ADSL PMC6733417__F2 Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets KLF15 HGF SMAD2 BMP7 MTOR PMC506920__F6 Changes in transcripts associated with the DNA synthesis pathway CDC45 CDC6 CDK2 ORC2 PMC8319838__F3 Temozolomide resistance in glioblastoma - a comprehensive review EGF BAD EGFR PTEN MTOR PMC8319838__F4 Temozolomide resistance in glioblastoma - a comprehensive review APC LRP5 TCF4 NLK CTNNB1 PMC8761945__F3 Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review CDC42 DOCK7 ARHGEF1 ARHGEF7 KALRN DOCK4 MCF2L RHO ARHGEF10 PMC8319838__F5 Temozolomide resistance in glioblastoma - a comprehensive review STAT3 ULK1 ATM MTOR XBP1 PMC4002322__F1 AMPK-p53-mTOR pathway in metabolic adaptation DRAM1 RHEB HEL-S-20 PMC11079312__F8 Proposed lipogenic pathway regulated by MUL1 during conditions of HFD NDUFS6 FASN MUL1 NDUFAB1 PMC4002322__F2 p53 regulation of energy metabolism HK2 TIGAR SCO2 GLS2 PMC7073173__F2 BMP signaling pathways BMP7 MTOR PMC5339410__F6 JAK-STAT and chemokine signaling pathwaysA STAT3 IRF9 JAK3 IL2RG SOCS3 CCL2 MAPK3 IFNGR2 BCL2L1 STAT5B IFNAR2 SOS2 LYN GRB2 JAK1 SRC PMC8508623__F1 Signaling Enzymes and Ion Channels Being Modulated by the Actin Cytoskeleton at the Plasma Membrane SYK INSR LYN PMC7874141__F1 Hypothetical model to illustrate activation of the complement system, inflammation and coagulation following SARS-CoV-2 infection HEL-S-62p C2 PMC9569742__F1 Antiaging Activities of Phytochemicals in Dark-Colored Plant Foods: Involvement of the Autophagy- and Apoptosis-Associated Pathways ATG101 ATG3 ATG12 TFEB ATG14 ATG5 PMC6726207__F1 Small molecules enhance knock-in efficiency RAD52 RAD51 BRCA2 RS1 ATM PMC6441195__F3 Exo-circRNAs play a crucial role via their sponging function and can be secreted into body fluid in tumors MACC1 PRDM16 EZH2 CCNA2 PMC7996181__F9 Mechanosensing by the nucleus SRC LMNA PMC7996181__F8 Hippo pathway and the role of YAP and TAZ in mechanotransduction of SC activity LATS1 LPA LATS2 TEAD2 PATJ TEAD3 AMOT PTEN RHO NF2 TEAD4 PMC3951857__F1 Wnt/Beta-catenin signaling pathway SOST APC LRP5 PMC2649571__F7 Beta-Catenin-Dependent Wnt Pathway Mediates Anteroposterior Axon Guidance in Motor Neurons APC POP1 CTNNB1 PMC6589846__F1 Schematic illustration of the interleukin (IL)-12/IL-23 pathway STAT3 STAT4 IL6 IL23R TYK2 IL12RB1 PMC5484415__F7 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy GLS MTOR MYC PMC3185594__F8 Signaling pathways involved in JSRV Env-induced cell transformation RHEB TLR4 HYAL2 MTOR SRC RAC1 PMC8126205__F6 Immunomodulatory Effects of Vitamin D Supplementation in a Deficient Population NR1i1 TLR4 IKBKB IFITM3 CD14 IKBKG PMC2291100__F1 Proposed biosynthetic pathway of Tcm PKS and a comparison of hypothetical intermediates for two possible folding pathways F2 COCH PMC5294827__F4 Sexual dimorphism in the axonal signaling pathway CDC42 NGF ITGB1 NGFR PLXNB1 ERBB2 ARHA RND1 PMC4991391__F4 N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications MGAT5 EGF EGFR PMC10619560__F4 Biosynthetic pathway of caproic acid and other organic acids in C. butyricum GD1-1 HBD PMC5484415__F3 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy GLS PSAT1 ASNS GPT PMC5484415__F4 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy OGT GLS ATF4 EIF2A PMC5484415__F5 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy GOT2 ME1 PMC4991391__F1 N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications BAX EGFR SMAD2 APC BRAF SMAD4 BCL2 MTOR KRAS CCND1 CTNNB1 PMC5484415__F6 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy GLS ARF1 MTOR SLC38A9 PMC5434854__F5 Top ranking gene network by gScore from the gene list uploaded from the SSRI versus control analysis CDC42 NCR2 GRB7 HGF FYN TIAM1 SP1 HIF1A GRB2 RAC1 PMC2801866__F3 Thrombospondin-1 (TSP1) binds to two receptors on endothelial cells that inhibit NO signaling FYN CD36 SRC CD47 PMC5434854__F6 Most significant canonical pathway from the gene list obtained from the esciptalpram versus control analysis CDC2 PAQR9 MFAP1 ATR TTC14 DNASE1L2 ATRIP H2AX ZNF652 MYT1 ZDHHC3 RPS20 RPS10 SOX9 BRCA1 ZNRF1 USP1 CHMP1A ABCA3 RXRB PMC2801866__F4 NO/cGMP pathway is a signaling node for pro- and anti-angiogenic signaling FYN CD36 SRC CD47 PMC2435382__F11 Hypothetical scheme illustrates the putative intracellular signaling cascades serving as the context for the data collected in the current study NONO GRB2 BDNF PMC7502477__F3 Chemical Structure and Biosynthesis of NAD+ NAPRT HEL-S-90n NAMPT PMC7212029__F6 Wnt negative regulation in ligand-dependent (LD) and ligand-independent (LI) tumours NKD1 RNF43 APC NOTUM LRP5 LRP6 GPR49 PMC4684266__F1 Simplified scheme of sulfur metabolism with an emphasis on the H2S-generating reactions PMC2801866__F1 VEGF binding to VEGFR2 on endothelial cells activates its Tyr kinase activity and results in autophosphorylation of the receptor at several cytoplasmic sites RAF1 SHB SRC PMC8117458__F7 Neuropathies and neurological dysfunction induced by coronaviruses BAX BDNF ACE2 PMC4489419__F1 Speculative model of FGF23 gene transcriptional regulation NR1i1 WNT3A FGFR1 PTH CTNNB1 PMC3407651__F1 STAT3 signalling pathway in ALK+ ALCL STAT3 ICOS ALK LAT JAK3 MEI1 IL2RA HIF1A SOCS3 PMC10474093__F9 Working model CCL22 CCR4 CCL17 PMC9139536__F3 Novel T Follicular Helper-like T-Cell Lymphoma Therapies: From Preclinical Evaluation to Clinical Reality STAP2 ICOS SYK CD80 PLCG1 LAT APC ITK VAV1 ARHA GRB2 LCK PMC8733955__F2 Metabolism of invading and circulating (detached) cancer cells VEGFC WNT3A HEL-S-133P FABP1 SMAD2 FASN SPARC SOX2 TWIST2 FABP4 ACOT12 ACSS2 CAMKK2 FABP5 SCD5 PC ASNS SRC GLS2 CPT1A SOX4 PMC8733955__F3 Metabolism of cancer cells colonizing in distant organs FABP5 PHGDH CD36 FASN SIK2 PC FABP4 SRC HEL-S-51e PRODH PMC8035038__F8 Potential molecular mechanism of anticancer effects of SLT on ovarian cancer CDH2 BAX CCND1 CDK4 PMC8998816__F2 FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms ERCC1 RARA CEBPA PDCD1 YTHDF2 BNIP3 IL2 HOXB13 SOX10 CXCR4 ASB2 MZF1 PMC7603193__F1 Interactions between non-coding RNAs and the TGFB signaling pathway in hereditary hemorrhagic telangiectasia (HHT) SMAD1 DGCR8 DKFZp781O1323 SMAD2 SMAD4 DROSHA TGFBR1 PMC3407651__F2 MEK/ERK signalling pathway in ALK+ ALCL RHEB RPS6 ALK JUNB MTOR PMC3407651__F3 PI3K/Akt signalling pathway in ALK+ ALCL RPS6 ALK CCND2 SHH SMO PTEN MTOR PMC12243992__F2 Palmitoylation of EGFR, VEGFR, ER and GP130 RAB27A EGFR IL11 GRB2 ZDHHC13 ZDHHC3 PMC9520191__F10 Polysaccharide from Atractylodes macrocephala Koidz binding with zinc oxide nanoparticles: Characterization, immunological effect and mechanism CD80 TIRAP TLR4 IL1B MYD88 PMC5148674__F3 The p53 tumor suppressor in metabolism and diabetes PGC RRAD HEL-S-20 ARHA GLS2 PMC2844217__F1 Schematic representation of the biosynthetic pathway of emetine, cephaeline, and related alkaloidal glucosides in P ME3 ME2 ME1 PMC5378285__F8 A hypothetical mechanism for the anti‐tumor effects of verteporfin in pancreatic ductal adenocarcinoma (PDAC) cells BAX CCNE1 MMP2 CCND1 PMC3772385__F8 Model describing the relationship of osteoblast-produced Bmp2 and connections to VegfA production and increased microvascularization that serves as a major niche for mesenchymal stem cells COL1A1 BMP2 MSC VEGFA PMC5155150__F6 Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells LEFTY1 DKK1 BMP4 CER1 SFRP1 PMC11818554__F7 Pathway regulating MSC osteogenic differentiation SMAD2 SMO ATF4 PTH RUNX2 CTNNB1 PMC11818554__F2 Wnt Signaling in MSC osteogenesis JUN SOST ZBP1 APC LRP5 MSC PC WNT1 WNT3 RHO CTNNB1 PMC6905465__F2 DNA damage response pathway FANCE BAX ATR RAD51 ATM PMC4007761__F2 Secretory pathway components studied in zebrafish and implicated in human diseases SEC31A TRAPPC9 ZNF547 SAR1B TRAPPC11 SEC24C PMC2905230__F1 Simplified Overview of TLR Signaling TLR4 CD14 IRAK1 IRF3 IRF7 IRAK4 PMC8141582__F7 Synergistic Effect of Statins and Abiraterone Acetate on the Growth Inhibition of Neuroblastoma via Targeting Androgen Receptor TSC2 TSC1 CYP17A1 HMGCR FDPS MTOR PMC4887533__F1 Overview of the ferroptosis pathway TFRC GLS2 HEL-S-64p PMC7037253__F1 IL-10 production is metabolically regulated STAT3 IL10 TLR4 PBX1 AHR CD46 MTOR SIRT1 PMC7037253__F2 Anti-inflammatory response initiated downstream of the IL-10R ZFP36 STAT3 IL19 SBNO2 HGF OSM ETV3 DDIT4 LIF GSK3B IL10RA SOCS3 NFIL3 HMOX1 STAT1 IL24 TYK2 PMC2756670__F3 Potential mechanisms of estrogen-mediated signaling through estrogen receptor (ESR) and G protein-coupled receptor 30 (GPR30) HBEGF EGFR SRC PMC2756670__F4 The proposed model underlying the potential lithogenic mechanisms of estrogen through the estrogen receptor 1 (ESR1) pathway in the liver ABCG8 ABCG5 ABCB11 ABCB4 PMC4307189__F2 Network view of (A) 104, (B) 188, and (C) 299 putative drug-resistant cross-talks between pathways using Reactome, KEGG, and WikiPathway pathway databases in Breast Cancer Cell-line: SKBR3 (GSE38376) GNAS NGF ERBB4 EGFR KIT SMO RHO MYC KRAS PMC3035754__F1 Regulatory network governing mitochondrial functions orchestrated by PGC-1A NR1C1 SIRT1 VHL PMC9495868__F4 Suppressing the PI3K/AKT Pathway by miR-30d-5p Mimic Sensitizes Ovarian Cancer Cells to Cell Death Induced by High-Dose Estrogen SRSF7 RPS15A SKIL SMAD1 SMC3 SMAD2 MYC MAPK8 BMI1 MED29 CDK6 SP3 MDM2 NOTCH1 PRPF19 SIAH1 EZH2 RNF2 RANBP2 MAP3K1 NEDD4 SAP18 UBE2D2 IRF2 CALM1 MAP3K7 UBE2E1 ENO1 TBK1 HEL113 PCNA PPP1CC IGF1R YY1 PRPF40A WDR5 KPNA2 HEL25 SUMO3 BTRC HIPK2 YWHAQ DHX15 MYH9 RPLP1 UBE2D3 ATM APP DYNC1H1 EEF1A1 ISG15 CLTC CCND1 YWHAG BIRC3 CDC2 DDX5 JUN IQCB1 ITGA4 RPLP0 CUL5 DCUN1D1 CBX3 RAC1 PABPC1 SEC24C UBE2D1 PARP1 VHL RUNX1 FZR1 PRKDC CASP3 HDAC9 BIRC2 REL DDX3X BCL6 YWHAZ PMC4503552__F1 Endocannabinoid system giving rise to endocannabinoids (2AG and AEA) and arachidonic acid and subsequently synthesis of prostaglandin glycerol esters, prostanoids, and prostamides PTGS1 PTGS2 MGLL FAAH PMC12014746__F4 Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats VEGFB TLR4 VEGFA PMC9599575__F3 Glycation-Associated Diabetic Nephropathy and the Role of Long Noncoding RNAs EGF IGF1 INS SIRT1 IL1B PMC12131810__F5 Signaling pathways for axonal regeneration within neurons STAT3 GAP43 PINK1 CAMKK2 SNPH SOCS3 MTOR PMC3882535__F3 Novel GPCR-based signaling mechanisms in ASM PLCB1 RGS4 PMC8478603__F1 Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells CD40 CD80 PMC4478640__F8 Model for negative feedback loop by which the ARGOS family desensitizes ethylene signaling OSR2 OSR1 PMC7407804__F1 Signaling events downstream of EphA activation by ephrin-As ARHG VAV3 VAV2 ARHA RAC1 PMC3408193__F9 Proposed protective pathway by E-LP against glutamate-induced apoptosis in RGCs PLCG1 GSK3B A2M PMC5404978__F10 Proposed model for FoxO1 and AMPK regulation of EtOH-induced autophagy ULK1 AMBRA1 ATG14 SQSTM1 PMC9027827__F3 Advances in the development of new biomarkers for Alzheimer’s disease LPL CASP9 FAS CASP8 CDK5 CASP12 GSK3B CASP3 PIGS MTOR TNF FADD PMC8788185__F3 Molecular mechanism of therapeutic approaches for human gastric cancer stem cells STAT3 SMO CTNNB1 PMC9675776__F9 GediNET for discovering gene associations across diseases using knowledge based machine learning approach BAX EGF NRP2 PTEN ACACA VEGFA MYC ALB RICTOR CHUK ATM XDH UMPS PMC316360__F6 Interphase/S phase omission between the two meiotic divisions MOS WEE1 MYT1 PMC5663306__F1 Bile acid metabolism and signaling in liver disease and therapy CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC6563994__F6 Social status regulates the hepatic miRNAome in rainbow trout: Implications for posttranscriptional regulation of metabolic pathways PIGC RRP8 ENO2 MYH6 KCNA4 MPC1 HEL-S-30 PCK1 CPEB4 PDHA1 HEL-S-68p PFKP HEL-S-49 HEL-S-162eP PC TAC4 ENO1 ATF4 PFKM PMC9180999__F4 PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity CGAS PQBP1 IRF3 IL6 TNF PMC5434854__F1 Top ranking gene network by P‐value from the gene list uploaded from the NRI versus Control analysis CDK8 TAF1 CREB3 RPS3 ID4 DEDD ATF1 CREB1 PMC5434854__F2 Top ranking gene network by gScore from the gene list uploaded from the NRI versus control analysis UBC TRAK1 NTSR2 NPY1R MAL NTSR1 TRAF6 IRAK4 MYD88 MAP3K7IP1 NPFF TLR4 TRAK2 GALR2 PMC5434854__F3 Association between the gene list and known processes pathways reveals a role for Glucocorticoids FKBP4 SUMO1 GRIP1 NFKBIA PMC5434854__F4 Top ranking gene network by P‐value from the gene list uploaded from SSRI versus control group analysis PAQR9 RPL18 CDC20 RPL11 TJAP1 APC PRICKLE4 POM121 RPL13 CPOX TPR RPL13A NAB1 VAT1 COG1 NUP210 CREB1 NUP58 PMC4073101__F3 Cilia and cilia-associated proteins in cancer STAT3 AURKA HGF TGFA HEL-S-133P EGFR ROR2 MTOR NEDD9 VHL MMP2 SRC CCND1 PMC6944116__F5 Protein interaction and functional clustering of identified hits and known UV‐G2 checkpoint components RAD18 STAT3 ATR MASTL PCNA PPP2CA SKP2 VCP FBXO32 CDKN2A GDF15 SMARCA4 CDK4 JUN RAD51 FEN1 WRN LZTS1 UBE2E2 PPP2R1A RPA1 XPC PARP1 ENSA DDB2 ARPP19 PHLDA3 DDB1 NONO BTG2 PPP2R2A SCRIB LMNA PMC4802403__F1 The mTOR pathway, it's classical upstream inputs and downstream targets.mTOR exists as two separate signalling complexes which are structurally distinct TSC2 RICTOR GRB10 TSC1 EGFR TBC1D7 GRB2 MTOR DEPTOR IRS1 PMC8617565__F4 Proteome Analysis of the Hypothalamic Arcuate Nucleus in Chronic High-Fat Diet-Induced Obesity MAPK14 CRK NGF BAD FRS2 GSK3B GRB2 BDNF SHC3 PMC7961974__F8 Pathway activation patterns of the NOTCH pathway in the different CD-groups APELA CREBBP NUMB LFNG PMC11466965__F6 Signaling pathway of HO-1 in the protection of diabetic nephropathy NLRP3 GPX4 FACL4 TNF PMC4876232__F1 FGF21 induces preventive effect on CVDs through multiple signaling pathways BAD NR1C1 FGF21 SIRT1 PMC11466965__F4 HO-1 may be involved in diabetic cardiomyopathy by regulating various signaling pathways BAX NLRP3 GPX4 SMAD2 PMC6410037__F2 Telomere length maintenance mechanisms POLD3 RAD52 RAD51 PCNA CTC1 STN1 TERT TEN1 PMC7842273__F1 Two major arginine metabolic pathways: NO synthesis vs AMD1 ASL OTC ARG1 ARG2 PMC6364748__F2 Oncogenic and tumor suppressive signaling involving Dmp1 and Arf TBX2 JUN EZH2 PTEN YY1 TNF MYC BMI1 ATM TBX3 MDM2 TWIST1 CCND1 CDK4 PMC2753833__F4 Transition to endocycles in Drosophila CDC2 CDC6 APC PMC9363567__F3 Macrophages: A communication network linking Porphyromonas gingivalis infection and associated systemic diseases CD14 CD47 PMC4698487__F2 Perspective on targeting copper metabolism for the treatment of hepatocellular carcinoma ATOX1 CCS ATP7B COX17 HEL-S-44 PMC3702256__F1 Pathview: an R/Bioconductor package for pathway-based data integration and visualization CDC45 SMC3 TTK ATM MCM2 SKP2 PMC4320984__F8 Activation of Beta-catenin Signaling by TFF1 Loss Promotes Cell Proliferation and Gastric Tumorigenesis TFF1 GSK3B CCND1 CTNNB1 PMC1369209__F3 Models for ECT-2 activation and its role in activating the EGFR/RAS/MAPK pathway EGF ECT2 EGFR GRB2 PMC5392598__F4 Schematic overview of the sex development gene regulation network LHX9 FOXL2 SOX9 SRY FGF9 NR5A1 WNT4 CTNNB1 RSPO1 PMC11906670__F2 Biosynthesis pathways and receptors of AA-derived eicosanoids and their influence on cDC migration LTA LOX COX1 KPG_011 CCR7 PMC11906670__F3 S1P synthesis and influence on cDC migration S1PR1 S1PR3 CCL19 CCL21 SPHK2 S1PR2 SPHK1 CCR7 S1PR5 S1PR4 PMC10136533__F2 Regulatory network of OTUD5 in immune response and DNA damage repair PDCD5 BAX TBK1 UBR5 RORC CGAS SSRP1 IRF3 IRF7 TRAF3 MYD88 PMC8804138__F3 Single nucleotide variants of receptor for advanced glycation end-products (AGER) gene: is it a new opening in the risk assessment of diabetic retinopathy?—a review LPA HMGB1 C2 PMC10136533__F3 OTUD5 is involved in the development of cancer (see also Table 1) PDCD5 TRIM25 CCR2 PML OTUD5 PTEN RNF186 MTOR DEPTOR PMC9208207__F5 Transcriptional changes in the peripheral blood leukocytes from Brangus cattle before and after tick challenge with Rhipicephalus australis TBK1 TRADD IKBKE TAB3 GSK3B TRAF3 CCL2 TRAF6 CSF3 IFNG TRAF4 IL17RB CCL7 IL18 MMP3 CEBPB CCL17 IL1B MAPK1 USP25 IL17RC CSF2 CASP8 CCL11 IL13 IL4 PTGS2 MMP9 IL6 TNF FOS IL17RA ELAVL1 RELA NFKBIA TRAF5 LCN2 CCL20 TRAF2 FADD PMC4624682__F5 Proposed model illustrating the multiple signaling pathways by which PGRN (Atsttrin as well) exerts its anti-inflammatory actions TRADD FOXP3 TRAF2 PMC11906670__F4 Biosynthesis and role of 7A,25-OHC in cDC localization within secondary lymphoid organs CCL19 CXCL13 CCL21 CCR7 CH25H CXCR5 CYP7B1 PMC11788143__F2 Signalling pathways in pancreatic and peripancreatic cells whose abnormalities cause diabetes of the young at maturity (MODY) PAX4 ADIPOR1 TCF2 MTOR INS BLK RHEB TSC2 TIEG2 PDX1 TSC1 NR2A1 RFX6 ABCC8 GCK PMC7326080__F2 TNF induced cell death signaling HMGB1 TRADD MLKL TNF TRAF2 FADD PMC7326080__F1 TNF induced canonical NFKB pathway SHARPIN TRADD OTULIN TAB3 RELA CYLD TRAF2 PMC8508208__F1 Cancer Cell Death: Therapeutic Implications for Pancreatic Ductal Adenocarcinoma GOT2 ME1 KRAS PMC8794746__F1 New Insights into LINC00346 and its Role in Disease CDC2 STAT3 WDR18 MAL CCNB1 MYC CTNNB1 PMC6354878__F4 Signaling pathway and GO analyses were performed to identify the biological functions of the subsets of differentially expressed genes after BP5 treatment APC HEL-S-69p PMC8794746__F2 New Insights into LINC00346 and its Role in Disease SZRD1 ZNF655 ANKHD1 PMC6089846__F3 Rubone and the p53 pathway CD44 BAX MDM2 LEF1 CTNNB1 PMC8508208__F4 Cancer Cell Death: Therapeutic Implications for Pancreatic Ductal Adenocarcinoma TGFB1 OSM SHH NODAL ISG15 MTOR PMC8490884__F10 Neurodevelopmental Disorders in Patients With Complex Phenotypes and Potential Complex Genetic Basis Involving Non-Coding Genes, and Double CNVs GNAZ INPP5A SHOX NIPA2 BUD13 CYFIP1 GLRA3 NIPA1 LRRC40 ABHD4 RBFOX1 PMC4740183__F3 Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease ASL ALDH7A1 BHMT2 OTC CHDH ARG1 HEL-S-61p PMC5844108__F10 Different metabolic responses in acquiring FK866 resistance in CEM RES (a) and MDA RES (b) cells NAPRT HEL-S-90n HEL-S-133P NAMPT PMC6089846__F5 Relationship between AR translocation and the AKT signaling pathway RHEB FKBP5 TSC2 JUN TSC1 PTEN MTOR PMC3565434__F8 Schematic diagram of proposed CD44-regulated signaling pathway CD44 FYN LCK PMC7322178__F5 Metabolic impact of tyrosine kinase inhibitor (TKI) administration C2 EGFR MTOR RET PMC4611193__F2 The regulation of intestinal iron transport TF HFE HP PMC5540723__F3 VEGF/VEGFR signaling and the approved therapeutic agents targeting this signaling VEGFB VEGFC VEGFA PMC4882508__F1 Pathway Compartmentalization in Peroxisome of Saccharomyces cerevisiae to Produce Versatile Medium Chain Fatty Alcohols PEX7 C2 PEX19 PEX5 PMC5540723__F1 PD-1 pathway signaling and the targeting of the PD-1 pathway during cancer immunotherapy CD80 APC PMC4531352__F3 Maize Primary Metabolic Network Involving Key Genes and Metabolites Identified in This Study.Metabolites that were not identified in this study are shown in purple TH IVD CS PDK2 DST PMC7492291__F1 Apoptotic signaling pathways triggered in CD4+CD8+ double positive (DP) thymocytes during T PRLR FAS PRL GC TNF PMC6894428__F3 Simplified model of the molecular evolution of each colorectal cancer subtype CDX2 APC BRAF KRAS PMC5287404__F4 Roles of malyl-CoA/Beta-methylmalyl-CoA lyases and malyl-CoA lyase/thioesterases (red) in different acetate assimilation pathways: the methylaspartate cycle in H ME2 ME1 PMC4023931__F3 Digital Expression Profiling Identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as Potential Predictive Biomarkers for Neo-Adjuvant Chemotherapy Response in Paediatric Osteosarcoma HEL-S-31 SRSF9 ARHGAP22 SACS FAS PSG5 CLEC11A THRAP3 SPARC PTEN HMGN1 MYC FOS SPTA1 RB1 GPR34 CDKN2A BCL2L1 LATS2 ERMAP HEL-S-306 BCR COL4A6 WWOX PMC8375225__F7 Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer STAT3 COIL CDK4 PMC4833098__F3 Canonical PPAR signaling pathway LPL UBC AQP7 UCP1 HEL-S-28 ACD PLTP CPT2 PMC4083752__F1 Unexpected targets and triggers of autoimmunity SGK1 FOXO1 FOXO3A IL23R PMC8838632__F2 Alkaloids and Colon Cancer: Molecular Mechanisms and Therapeutic Implications for Cell Cycle Arrest CDC2 BAX CDK6 ULK1 CDK2 BCL2 MTOR APAF1 CDK4 PMC3019561__F2 Mitochondria and the synthesis of phospholipids PGP CDS1 PC PMC5489807__F3 Levels of crosstalk between the HIF and the NFKB pathways KDM2A RELA PMC7609840__F1 Relevant JAK-STAT signaling pathways in the pathogenesis of Spondyloarthritis STAT3 STAT1 JAK3 STAT4 JAK1 IL23R TYK2 IL12RB1 PMC5489807__F1 Activation pathways for canonical and non-canonical NFKB signalling LTB MAP3K7IP1 LTBR TAB3 RELA RELB TNF TRAF2 FADD PMC11598946__F3 Cytosolic sensing of BRSV by RIG-I, MDA-5, and NOD2 MAVS NOD2 IRF3 TRAF6 PMC11598946__F5 Some of the respiratory syncytial virus’s immune-evading mechanisms MAVS TLR3 TLR4 NOD2 IRF3 MYD88 PMC9354928__F2 Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma RHEB TSC2 TSC1 PTEN MTOR PMC8704013__F1 Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression ASL IL4 CCL2 PMC9354928__F3 Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma RHEB MLST8 ULK1 HIF1A ULK2 EIF4E PMC8704013__F2 Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression EGF CCR2 IL4 MTOR CCL2 TNF ARG2 PMC8616477__F2 Melanoma Targeted Therapies beyond BRAF-Mutant Melanoma: Potential Druggable Mutations and Novel Treatment Approaches ARAF TET2 BAX BAD BRAF BCL2 EZH2 MDM2 MTOR CDK4 PMC10820115__F3 Canonic polyamine biosynthetic pathway of mammals (hosts of trypanosomatids) EIF5A POT1 PMC7606114__F4 Lysosome and pyroptosis GSDMD NLRP3 IL16 PMC6851521__F2 The molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism ATG3 PTEN MTOR CTNNB1 PMC4941807__F5 Schematic illustration of the coagulation pathway and its inhibitor systems ANXA3 HGF ANXA4 TFPI PROS1 THBD A2M PROC PMC7887310__F1 IFN action on cellular metabolism pathways FAS IDO1 CH25H PMC4941807__F4 Ingenuity pathway analysis revealed hepatocyte growth factor (HGF) as an upstream regulator HRAS TGFBR2 STAT3 ANXA3 HGF THBD A2M HIF1A TNF PMC6379038__F2 Cholinergic signaling via nAChRs and muscarinic acetylcholine receptors (mAChRs) regulates striatal function TH STAT3 PMC5016220__F1 Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets SPN S1PR1 SPNS2 S1PR3 CERK ORMDL3 SMS S1PR2 S1PR5 S1PR4 PMC5016220__F2 Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets S1PR1 S1PR3 S1PR2 RHO S1PR4 PMC6851521__F1 Molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism STAT3 PTEN MTOR PMC5584221__F9 EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway SRC CTNNB1 PMC7770114__F7 Chronic administration of l-DOPA leads to a sensitization of D1 receptors, which maintain the over-activation of PKA in LIDs FOSB TRPV1 GPR6 FAAH PMC4315049__F2 Secretion of FABP4 in association with lipolysis PDE3B AQP7 GC FABP4 IRS1 PMC8750774__F2 Metabolic Implications of Immune Checkpoint Proteins in Cancer ICOS CD80 FES PMC8957101__F1 Hidden One: What We Know About Bitter Taste Receptor 39 TRPM5 PLCB2 CALHM3 CALHM1 PMC3887879__F3 Nutrient signaling to mTORC1 RHEB MLST8 SLC3A2 GLS RUVBL1 SH3BP4 RUVBL2 SLC7A5 MTOR PMC3887879__F1 MTOR signaling pathway RHEB TSC2 TSC1 TBC1D7 DEPTOR PMC4555691__F1 Schematic representation of sarcosine pathway HEL-S-182mP PIPOX PMC8979868__F2 Novel insights on GM1 and Parkinson's disease: A critical review UGCG GAL ST8SIA5 ST3GAL5 ST8SIA1 B4GALT5 B3GALT4 PMC3498346__F1 Impaired Skeletal Muscle Regeneration in the Absence of Fibrosis during Hibernation in 13-Lined Ground Squirrels MYF6 MYF5 PAX7 PMC5701683__F2 Signal transduction in melanoma with regard to the role of the SOX10-MITF pathway MIA TYRO3 BRAF NRAS MTOR CCND1 PMC4318882__F7 The murine parturition pathway GAA STAT5B PMC8192743__F12 Mechanistic insights into TNFR1/MADD death domains in Alzheimer’s disease through conformational molecular dynamic analysis TRADD TLR4 TRAF6 TNF MYD88 PMC8038160__F4 Flavonoids modulate growth pathways in cancer VIT RHEB EEF2K EGF TSC2 EGFR EEF2 PTEN GRB2 MTOR DEPTOR PMC8038160__F2 Flavonoids modulate inflammation and immunity pathways in cancer VIT STAT3 TRADD NLRP3 TLR4 TRAF5 MMP2 MMP9 SRC TRAF6 TRAF2 PMC3649201__F1 Current view on the complex interplay of pathogenic factors in cholesterol gallstone formation ABCG8 ABCG5 HEL-S-70p PMC7838196__F8 PI3K-AKT signaling pathway SYK MYB BAD RAF1 BCR CD19 PTEN MTOR RAC1 PMC8468898__F4 Validation and Selection of New Reference Genes for RT-qPCR Analysis in Pediatric Glioma of Different Grades ACLY HEL107 FH SCD HEL-S-162eP FASN CS ACACA HEL-S-30 PMC4710243__F1 Beta-Catenin participates in cadherin-mediated cell adhesion and is a transcriptional coactivator in the canonical Wnt signaling pathway APC GSK3B PMC4308835__F1 Nuclear factorK B activation pathways CD40 TLR4 RELB CD14 PMC3703119__F5 Schematic representation of the pathogenetic mechanism of AD copper phenotype ATOX1 ATP7B COMMD1 PMC4046186__F1 Intrinsic and extrinsic apoptosis signaling pathways (adapted from ref CASP9 CASP8 CASP6 CASP2 TRADD CYCS CASP3 APAF1 FADD PMC4947825__F1 Cascades of the coagulation system TF VWF TFPI PLG PC PMC4947825__F2 Interactions between coagulation and inflammation during IAV infection VWF TFPI VCAM1 PMC4965186__F5 a) Systems modeling framework used in this study RPE MLNR PMC11032739__F7 Musashi2 affecting radiosensitivity of lung cancer by modulating DNA damage repair ATR H2AX RBM17 PMC7226820__F3 Main signaling pathways involving LSEC during liver regeneration HGF WNT9B NOTCH1 PMC4629055__F2 Divergent macrophage activation pathway CCL22 CCL18 CCL2 CCL17 PMC9234708__F3 Biomineralization associated alkaline phosphatase as a potential marker of bone metastasis in the patients with invasive breast cancer PPARG ALPI ALPL FOLR3 LVRN COL10A1 ENPEP HHIPL2 RUNX2 MRAP2 RUNX3 CD34 MRAP APOA4 RUNX1 ERAP1 ALPG BMP2 GPLD1 PMC8038136__F1 CK1A and CK2 regulate many cellular processes that sustain the tumor phenotype BCL10 CARD11 APC GSK3B PTEN ATF4 CDC37 MDM2 MTOR CTNNB1 PMC3960188__F1 mTOR pathway in colorectal cancer: an update RHEB TSC2 TSC1 PTEN IRS1 PMC4669955__F2 Emerging Role of ABL Kinases in Solid Tumors DAB1 TRIO ABL2 RHO MTOR SRC CXCR4 CCND1 RBPJ PMC3960188__F2 mTOR pathway in colorectal cancer: an update RICTOR GRB10 SGK1 MTOR PMC2688755__F2 Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen FANCD2 ATR FEN1 PCNA RPS3 H2AX BRCA2 ATM POLE TDG PMC3721286__F3 Simplified scheme presenting multiple feedback loops in the EGFR pathway ZFP36 LRIG1 JUN EGR1 MAFF EGFR GRB2 MYC FOS PMC7864484__F2 Nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family apoptosis inhibitory protein (NAIP)-NLR family caspase recruitment domain-containing protein 4 (NLRC4) inflammasome-mediated PANoptosis, inflammatory cell death NLRC4 GSDMD CASP8 MLKL CASP3 IRF8 PMC3730684__F1 The Smad-dependent TGFB signalling pathway upon stimulation with TGFB and BMP VIT SMAD1 SMAD2 SMAD4 SI PMC9260904__F10 Genome-wide Meta-analysis Reveals New Gene Signatures and Potential Drug Targets of Hypertension ADM EGFR EDN1 CEBPD TNF PMC7524949__F2 Synthesis, release, and metabolism of intra- and extra-cellular purines PNP ADA PMC2725405__F6 Regulation of IFN response genes by TLR3 signaling TLR3 IRF3 ATF2 PMC3832239__F2 Mitochondrial Retrograde Signaling at the crossroads of tumor bioenergetics, genetics and epigenetics EBP RYR1 IGF1R PMC8946699__F1 New Directions and Challenges in Targeted Therapies of Advanced Bladder Cancer: The Role of FGFR Inhibitors PTEN MTOR PMC4134018__F3 Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii BCL2A1 BCL2 PMC4383015__F5 Foxp3-biding genes in ‘pathway in cancer’ SMO C14orf166 VHL PMC7048211__F4 Proposed direct role of HTRA1 in bone formation SMAD1 DKFZp781O1323 SMAD2 BMP4 BMP2 SMAD4 IBSP MTOR BMP5 PMC3919163__F2 LPS receptor signaling pathways TBK1 MAP3K7IP1 TLR4 TAB3 MAL IRAK1 IRF3 TRAF3 TRAF6 MYD88 PMC3271653__F1 Testosterone signaling pathways EGFR SRC PMC8538586__F3 Forms and Methods for Interferon’s Encapsulation STAT1 MAVS STAT2 IFNAR2 IFIT1 IFNAR1 IRF3 MX1 IL10RB PMC6174781__F4 Colon Epithelial MicroRNA Network in Fatty Liver RPS15 EIF4G1 MMP14 HEL-S-107 ELAVL1 EPO MMP2 MMP3 PRKCZ PPP2CA PROC PMC10744281__F1 Interconnection of glycolysis with other metabolic pathways EGF PFKFB4 FH HK2 FASN MTOR ME1 RHEB TSC2 TSC1 HMGCR HEL-S-32 MDH2 HEL-S-26 CIT PMC10744281__F3 Apoptotic process by glycolysis and lipid metabolism in glioma BAX HK2 FASN BCL2 FADD PMC10744281__F4 Autophagy by glycolysis, lipid metabolism, and glutamine in glioma EGF GLS HEL-S-133P HK2 ULK1 SPHK1 FASN BNIP3 HIF1A MTOR RHEB ATG10 TSC2 TSC1 HMGCR HEL-S-68p TFEB BCL2 AKT1S1 SIRT1 ULK2 PMC5549471__F2 HN inhibits OS and ER stress in RPE by direct and indirect mechanisms STAT3 ATF4 EIF2A PMC6290495__F4 Regulatory model for the flow pathway of central carbon metabolism and a proposed scheme for lipid biosynthesis in T LPA MCAT OGDH HEL-S-162eP CS PMC5818417__F2 Anti-fibrotic effect of selected polyphenols SMAD2 SMAD4 NOX4 PMC4691085__F2 Crucial role of miRNAs in coordinating vast prostate cancer (PC) metabolic processes HEL107 HMGCR GLS FASN PMC3841791__F9 Predicted upstream regulators inhibited in DA rats but activated in congenics PPARG JUN EGR1 NR1H3 SP1 AGTR1 RUNX2 MYC FGF2 CTNNB1 RB1 CEBPA CDKN1A FOXO1 FOSL1 RELA NFKBIA LIPE CEBPB CREB1 PMC4563160__F8 FASN inhibition blocks metabolic and signal transduction pathways vital to cancer cell growth, proliferation, and survival RPS6 FASN LRP6 MTOR MYC CTNNB1 PMC3789231__F7 Mechanism for epithelial–mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3) STAT3 BTRC ELP2 EGFR GSK3B PMC6346071__F1 Cysteine anabolism and catabolism pathways GOT2 pcap HEL-S-64p PMC4086482__F1 Phosphoinositide-3-kinase-Akt-mTOR pathway RHEB TSC2 TSC1 PTEN MTOR EIF4E PMC8394255__F2 Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina STAT3 GC PAX6 CTNNB1 PMC4134018__F1 Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii HEL-S-130P RAB1B RHO EEA1 PMC5635482__F1 DNA interstrand crosslink (ICL) repair: Crosstalk between the Fanconi Anemia (FA) pathway, translesion synthesis (TLS) and homologous recombination (HR) ATR RAD51 PCNA FANCM FANCA FANCB FANCD2 MCM7 CDC45 USP1 MCM3 MCM5 MCM6 MCM2 PMC6927724__F8 MicroRNA-23a-3p improves traumatic brain injury through modulating the neurological apoptosis and inflammation response in mice PTEN MTOR IMPACT PMC7227813__F2 Anti-lipolysis regulation by insulin on the morphological differences of adipose tissue PDE3B IRS1 PMC8022592__F5 Differential regulation of breast cancer cell growth by methyljasmonate (MeJA) or MeJA‐treated leaf disks CCND3 CCNE1 CDC6 CDK2 CCND1 PMC11079205__F3 GLP-1 effects on bone FAS RUNX2 GAB2 PMC11079205__F4 Incretin hormones’ effect on bone PYY IGF1 GIP PTH RUNX2 GIPR PMC3704444__F1 Interaction between quality control systems for ER protein folding and RNA biogenesis DIS3 UPF2 SGA56M SMG1 SMG6 ELF2 EIF2A EXOSC3 PMC11012798__F2 C and N metabolisms affected by N sources FRK HEL-S-162eP PMC11079205__F1 Bone remodeling is a dynamic process that is completed with the participation of BMU IGF1 MSC PTH PMC11079205__F2 The GM and gut hormones on bone metabolism VIT TH PYY IGF1 PMC3961644__F8 Proposed model for the negative or positive regulation of chondrocyte maturation or apoptosis by Smpd3/nSMase2, respectively ACAN SOX9 BMP2 HAS2 COL10A1 RUNX2 COL2A1 PMC11033413__F2 Progress of medicinal plants and their active metabolites in ischemia-reperfusion injury of stroke: a novel therapeutic strategy based on regulation of crosstalk between mitophagy and ferroptosis IPP HMGCR GLS GPX4 HILPDA NF2 PMC12154018__F3 Inhibitors targeting the PI3K/Akt pathway, clinically approved for cancer treatment TSC2 TSC1 PTEN EIF4E PMC12154018__F1 PI3K/Akt signaling pathway PRR5 MLST8 TSC2 TSC1 EGFR PTEN MTOR DEPTOR PMC5924546__F3 Wnt signaling pathway regulates deiodinases LRP5 LRP6 CTNNB1 PMC1860011__F2 PPARG as a new therapeutic target in inflammatory bowel diseases JUN VCAM1 FOS PMC4184787__F2 Gene Expression during the Generation and Activation of Mouse Neutrophils: Implication of Novel Functional and Regulatory Pathways NCEH1 TG SOAT2 MGST2 IL18 IRF3 PLTP PMC3409471__F2 Clinical Implications of Cancer Stem Cell Biology in Hepatocellular Carcinoma STAT3 EGFR APC GSK3B FHL2 PTEN HIF1A CTNNB1 EPCAM CDX2 ADAM17 GATA6 NLK ABCG2 LEF1 PMC6949069__F6 The breast cancer pathway BRCA2 KIT PTEN PMC8194146__F5 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer WNT5B WBP2 IMP3 NCOR1 WNT3A EGFR SKI CTNNB1 PMC8194146__F7 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer SOX2 PMC4290680__F1 Structural model of and cell signaling pathways triggered by ManLAM and its biosynthetic precursors LM and PIMs SYK IL10 JUN TIRAP KSR1 CD14 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TLR1 TLR4 CARD9 PMC4290680__F2 ManLAM and PIM action on phagosome maturation and autophagy IFNG RAB14 ULK1 MTOR PMC7227813__F1 Anti-lipolytic action of insulin PDE3B ATM PMC8194146__F2 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer LATS1 MOB1A MOBKL1A LATS2 PMC5710110__F2 Transforming growth factor B (TGFB)-induced Smad signaling pathway CDK8 ID2 SMAD2 SMAD4 CDK9 ID1 CDK4 ID3 PMC5710110__F3 Transforming growth factor B (TGFB)-induced transcriptional program and its alterations in cancer CDC2 ATF3 E2F4 SMAD4 MYC FOXG1 PMC8194146__F3 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer LATS1 FOXM1 LATS2 YAP1 PMC8194146__F4 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer LATS1 LATS2 CRABP2 ZNF367 USP9X PMC6395693__F5 Transcription factor regulatory effect network identified using Ingenuity Pathway Analysis (IPA) LDB3 TCAP HSPG2 HEY2 MYH6 ZYX KDM5A IFI16 DMPK GPX1 FLNA MYH7 MYH9 NKX2-5 GATA4 PMC8393760__F4 Molecular Aspect of Nephrolithiasis Development ASL OTC PMC8393760__F3 Molecular Aspect of Nephrolithiasis Development APRT PNP XDH PMC6834311__F2 The most common signaling pathways influenced by probiotic strains employed in C CTNNB1 PMC7763898__F2 MicroRNAs expressed in periodontitis and their target in alveolar bone MAFB ARHA NFIA PMC7219112__F7 Gene-Concept network plot shows the linkages between differentially expressed genes for MAPK pathway-mutated (versus MAPK-WT) HNSCC tumors and GSEA enriched biological concepts GLDC PRKD2 TTBK1 IL33 CD7 C1QB CXCL3 ADGRE2 APOBEC3H IFNG PDCD1LG2 PSME2 THOC7 GOLPH3 PLGRKT ABCD2 CST7 RPL12 RPSA MUC19 ZDHHC3 RPS26 RPS24 SEC22A GPAM PARL KIR2DL4 ERCC1 TBK1 ARPC4 CRTAM ARHG HLA-DRB1 PHAX WDPCP GPX1 TMEM67 SLAMF7 RPL18A SPOP HCST KPNA4 XCL2 RPL14 GNLY KLRC2 FBXO6 PAIP1 PRELID1 ARHA SIRPG GPR171 PCBP4 SLC33A1 PANO1 SLA2 MS4A3 FASTKD3 SECTM1 PLEKHG5 ARRDC1 OXSR1 GORASP1 CLEC2B NUB1 ACKR4 GMFG RPS9 GIPR RPS15 PDCD1 RPL32 RNF123 CHCHD4 RPS14 RPL36 SKP2 RPS11 MYD88 APEH RPL29 RPL28 CNN2 PSMB10 KLRD1 PLA2G7 RPL27A UBA7 RPS23 RPS4X TNFSF6 IFITM1 SERPINA1 CTSL ZDHHC4 CLEC4D CLEC4E RNF213 BRK1 HRAS RPL3 TMF1 RPL23A EEF2 AIF1 KIR3DL1 RPL18 ZYX RPLP2 CSF3 AZI2 SEC22C TRIM21 ISG20 RPS27 HAVCR2 GBP5 NDUFAF2 IFNGR2 LSM3 RPL17 RPS13 USP15 UBE2D4 CARD16 GRPEL2 CACNB3 NCBP2 RPS6 BAX APOBEC3G RPS2 RIOK2 BATF2 GZMA RPL15 MT2A HLA-DMA PRF1 RPL13A LILRB2 THEMIS2 GALNS CISH PMC3620096__F1 Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles RAB32 TYRP1 RAB38 PMC3127250__F1 Autophagy and the integrated stress response ATG10 ATG3 ATG12 ULK1 VMP1 UVRAG AMBRA1 MTOR ULK2 PMC5557591__F5 Effect of masticatory stimulation on the quantity and quality of saliva and the salivary metabolomic profile NAGS HEL-S-20 OTC ACD MDH2 ARG2 PMC6052717__F2 Signalling pathways involved in ccRCC STAT3 SMO IL6 PMC4324684__F9 Proposed pathway of cytosolic jadomycin-induced ROS and their metabolism within MCF7 breast cancer cells PRX DDC HEL-S-44 PMC3670238__F1 Spectrum of STAT functions in mammary gland development PRLR SOCS1 HMFT1766 SLPI LIF PIK3R1 CD14 SOCS2 SOCS3 GATA3 IGFBP5 PRL IL13RA1 PIAS1 JAK1 TYK2 PMC7918168__F6 Action mechanism by gallic acid and rutin on mitochondrial functions in C2C12 myotubes TFAM SDHB FIS1 OPA1 MFN1 MFN2 MUL1 NDUFB3 NRF1 ATG5 PMC6140703__F8 A schematic model of GC development BAD PLK1 CCND1 PMC7461761__F1 Evolutionary Origins of Programmed Cell Death Signaling RRS1 RIPK3 GSDMD CASP8 ZAR1 TRADD MLKL APAF1 FADD PMC5591063__F4 Changes in Adipose Tissue During Weight Gain CCL5 CCL2 PMC6187096__F2 Ginsenoside Rh2 epigenetically affects genes in the cell-mediated immune response pathway RASGRP4 PANX1 GNRH1 RIMS1 ANK2 CHRM1 RASGRP3 CD69 CASP12 KDM5A HSBP1 SOX6 CTBP2 PNKD CASP5 ARHGAP18 BAZ2B CARD18 DGKZ HEL-S-15 RAB26 PMC6517553__F3 General principle of the HSV-TK suicide gene system FAS ATM TNF FADD PMC7060917__F4 Molecular docking and network connections of active compounds from the classical herbal formula Ding Chuan Tang CD40 BCR MBP APC EPO PMC7060917__F5 Molecular docking and network connections of active compounds from the classical herbal formula Ding Chuan Tang PPARG EGFR PDE4D KDR PMC5512555__F3 Notch signaling in the mammalian ovary BMP15 STAT3 STAR DLL4 ZP3 RAC1 STRA8 FOXI2 FOXL2 INHBA GJA4 HSD3B1 CYP11A1 JAG2 LFNG FIGLA GATA4 GDF9 GJA1 NOBOX PMC3823599__F7 MiR-103 Controls Milk Fat Accumulation in Goat (Capra hircus) Mammary Gland during Lactation LPL ACOX1 ABCG1 ACSL1 DGAT1 CD36 SCD FASN ACACA ABCA1 PMC7221190__F2 Complement-driven accelerated renal senescence after IRI-AKI leading to CKD progression LRP8 ICE1 TGFA HEL-S-62p LRP5 CS CTNNB1 CP PMC8847224__F2 Dissecting the Crosstalk Between Nrf2 and NFKB Response Pathways in Drug-Induced Toxicity LTBR RELA RELB TNF PMC12079202__F6 Overall network diagram of “drug-target-disease-pathway” BAX PLAT PTEN PMC10607277__F9 Compound–disease–therapeutic targets-core pathways network; red triangles represent diseases, blue triangles represent compounds, purple ovals represent pathways, and green ovals represent targets HSP90AB1 HEL-S-72p MAPKAPK2 GSK3B RAC1 PRKCB BCL2L1 FOXO1 RELA MMP3 CDK2 BCL2 HDAC2 CDK4 IL1B PMC11022503__F8 Proposed mechanism of erroneous differentiation of TSPCs under high glucose HMGB1 COL1A1 SCX RUNX2 TNMD PMC6612049__F1 Mechanisms of ionizing radiation sensitizing and resistant effects in various subtypes of breast cancer and irradiation-induced apoptosis BAX RAD51 BRCA1 EGFR UBE2D3 BCL2 LCN2 MTOR CTNNB1 PMC4136419__F1 Targeting the B cell receptor signaling pathway in B lymphoid malignancies SYK BTK BCL10 PLCG2 CARD11 CD19 LYN MYC PMC4136419__F2 Targeting the B cell receptor signaling pathway in B lymphoid malignancies SYK BTK BACH2 CCND2 BLNK RAG2 RAG1 IL7 LYN MYC PMC9221006__F3 Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers STAT3 SP1 HEL-S-133P IRF1 HIF1A MMP9 MTOR CTNNB1 IFNG SOX9 HEL-S-68p MMP2 JAK1 CCND1 PMC4698274__F1 Innate Immunity against Leishmania Infections NLRP3 TLR3 HEL-S-62p IL18 TLR9 IL1B MYD88 PMC10377042__F2 Potential Influence of Uremic Toxins on the Homeostasis of Bones and Muscles in Chronic Kidney Disease UCP1 AHR PTH PMC9312989__F6 Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies PIK3CA ROS1 STK11 EGFR BRAF PIK3R1 PTEN MTOR KRAS HRAS TSC2 TSC1 ALK NF1 RIT1 ERBB2 MAP2K1 RET PMC4536957__F2 Schema showing the multiple functions of FOXD1 lineage myofibroblasts in interstitial kidney disease MMP7 MMP14 TIMP1 SHH FAP ADAMTS12 ADAMTS2 PMC7796309__F1 Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease BACE1 C9 HBD HEL-S-11 PMC7661798__F4 Cellular response to growth factor (GF) via its receptor PIK3CA PTEN MTOR PMC6111708__F2 Hippo-YAP signaling and the pathogenesis of gastric cancer ATP4B RASSF6 CNTN3 THY1 THBS2 COL10A1 AKR1B10 ORM2 GKN1 TFF2 TFF1 COL1A1 ALDH3A1 PGA5 SULF1 ADAMTS12 ASPN ORM1 FAP SST ADH7 CYP2C18 FNDC1 SFRP4 UGT2B15 MFAP2 SLC26A7 HPGD HEL110 GKN2 CYP2C9 THBS4 CAPN9 TCN1 PGA3 CTCFL PMC9312989__F3 Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies SFRP5 DKK4 TLE3 APC TLE4 GSK3B LRP5 LRP6 TCF7L1 AMER1 MYC SFRP1 CTNNB1 TLE2 DKK3 TCF7L2 SFRP4 RNF43 DKK1 AXIN1 DKK2 WIF1 PMC3307371__F8 Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus GSK3A HSF1 GSK3B BDNF PMC4667791__F5 MAPK pathway has been invoked in phospholipase A2 activity that could release arachidonic acid, perhaps in concert with VEGF, and thereby amplify 20-HETE formation () CYP4X1 CYP4Z1 LOX CYP4F2 CYP4A11 PMC8626287__F2 Implication of the circadian clock in the regulation of neural signaling and behavior TSC2 TSC1 HOMER1 PER2 MTOR NOTCH2 BDNF PMC8204249__F5 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms CCL3 MSC TPO CCL4 TNF IL1B PMC11987923__F3 Tumor immune microenvironment in cholangiocarcinoma APC KRAS FGFR2 PMC8204249__F3 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms RIPK3 CASP8 TRADD MLKL TNF FADD PMC8204249__F4 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms FLT3 MPL CDK6 RELA S100A8 IRAK1 TPO TNF IRAK4 MYD88 PMC10218668__F1 Therapeutic peptides for lung diseases VIP NLRP3 FGF21 CNP PMC3381956__F1 Signaling pathways and their targeted therapies in NSCLC EGF TSC2 STK11 HGF TSC1 EGFR KIT PTEN HIF1A MTOR SRC FADD PMC4598753__F1 Nuclear receptors can alter NFKB signaling and activity TLR4 IRF3 TRAF6 MYD88 PMC3495118__F1 Transcriptional regulation of the cytoprotective phase 2 genes under control of the transcriptional factor nuclear factor-E2 p45-related factor 2 (Nrf2) KEAP1 CS PMC7750564__F1 NFKB signaling pathway is involved in the transcription of HIV which can be exploited for HIV cure studies RAF1 RELB TRAF3 BIRC2 TRAF2 HEL-S-34 BIRC3 PMC7072180__F4 FUT8 overexpression promotes DNA replication FUT8 PCNA RPA3 MAL CDK2 PMC6068284__F3 Fumarase functions in the human and yeast DNA damage response (DDR) to double-strand breaks (DSBs) FH SETMAR PMC7281640__F2 Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma SF3B1 EIF1AX BAP1 GNA11 PMC9144890__F5 CD44 Mediates Oral Squamous Cell Carcinoma-Promoting Activity of MRE11 via AKT Signaling CD44 MRE11A MB PMC1839891__F10 In this model, the tumor growth process is replaced with the cell cycle model from figure 7 CDC2 APC GSK3B SMO CCND1 PMC9832433__F4 Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis TF IL16 TLR4 APC PC MPO PMC6180192__F1 Nuclear factor erythroid 2-related factor 2 (NRF2) activation RBX1 KEAP1 SKP1 CS PMC9832433__F2 Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis HEL-S-133P FOXO1 F2 TLR4 VCAM1 MPO PMC9709224__F7 Oleic acid-induced steatosis model establishment in LMH cells and its effect on lipid metabolism TG MTTP FASN APOB PMC6094051__F6 Models for Golgi fragmentation induced by truncated APC APC ARHA RHO APC2 PMC8564353__F1 Exosome CTLA-4 Regulates PTEN/CD44 Signal Pathway in Spleen Deficiency Internal Environment to Promote Invasion and Metastasis of Hepatocellular Carcinoma CD44 PTEN PMC8204249__F1 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms STAT3 MPL HEL-S-99n CBL SH2B3 TPO PMC4983011__F1 Processes involved in particle-induced pro-IL-1B expression HMGB1 IL33 PMC5830721__F5 HIF-1 signalling pathway is enriched in proteins containing labile disulfide bonds STAT3 KHK TFRC HEL-S-133P TLR4 FRK IL6 MTOR HEL-S-87p VHL EIF4E PMC7859462__F4 Impact of 3′UTR APA on its target mRNA and protein CD47 RAC1 SET PMC8860994__F8 Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence BAX FYN TRADD SMS PTEN RHO TNF TRAF2 GAB2 PMC7355051__F3 Targeting mitochondria using endogenous cardioprotective strategies STAT3 MFN2 GC GSK3B PMC7490471__F1 ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway MAPK1 EGF WWC3 EGFR GRB2 PMC5173116__F7 Reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux OCEL1 PC MTOR PMC5007556__F1 SPATA2 – Keeping the TNF signal short and sweet STAT3 TBK1 SPHKAP EXOC4 TRADD MLKL RELB AKT3 TNF SHARPIN TMOD3 LIMCH1 RPS6KB1 CCAR1 RIPK1 TRAF2 CYLD PMC5899030__F3 multiple neuropeptides and receptors regulate the activity of neurons in feeding circuits GPR171 GPR83 POMC MC4R PC NPY AgRP PMC5770878__F6 The hypothesized protective effect of CR on retinal degeneration by ONVT: the pivotal role of elevated endogenous 3HB via ketolysis ACAT1 BDH1 NQO1 CS PMC534909__F2 Fas receptor pathway of apoptosis FAS CAD FADD PMC9484011__F2 Biosynthetic pathway leading to H2S production from L- and D-cysteine DAO PMC534909__F3 Cell survival signaling pathways BAX BAD FAS PMC3903252__F7 Schematic illustration of the TGFB/ENaC pathway in a generalized alveolar epithelial cell monolayer, described in this study PIP5K1A SMAD2 PC NOX4 PMC7069061__F6 Pathway of multiregulatory effects in Chinese medicine EGF RAF1 EGFR IL3 CXCL1 PTEN MTOR CTNNB1 IFNG NGF MMP3 IL2 TPO SRC MAPK1 BAX IL10 TNFSF6 IL4 CD40LG VEGFA IL6 ARHA CXCL10 IL5 CXCL11 RAI1 IGF1 CASP3 BCL2 IL7 PMC10310766__F2 Canonical pathway of p53 that regulates ferroptosis SLC25A28 FDXR ELAVL1 GPX4 SLC7A10 DPP4 ALOX15 SLC7A11 GLS2 PMC10310766__F3 Noncanonical pathway of p53 that regulates ferroptosis HEL-S-5 ALOX12 SLC7A11 PMC2674747__F1 Illustration of differences in the expression of genes for early steps of sphingolipid metabolism using a KEGG-based microarray analysis tool (GenMapp v2.1) that has been modified to display this pathway more completely (www.sphingomap.org) CERS3 ASAH2 CERS5 CERK SPHK2 CERS1 CERS2 SPHK1 SGPP2 PMC9307469__F1 Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients? TMPRSS2 IFNAR2 IFNAR1 IRF7 FOXP3 FURIN ACE2 PMC6935429__F3 Different DNA repair mechanisms RAD18 PCNA PMC5507876__F8 The diagram of rGal3C regulating NDRG1 through integrin/FAK/SRC pathway SRC PMC3592845__F7 Gli1 Deletion Prevents Helicobacter-Induced Gastric Metaplasia and Expansion of Myeloid Cell Subsets SHH IL1B PMC6493027__F2 Ingenuity Pathway Analysis (IPA) of ASS234 treatment MMP7 APC HEL-S-28 TCF4 RHO PIN1 SFRP1 CTNNB1 CD44 MAP3K7IP1 DKK1 NLK MDM2 WIF1 PMC5874277__F3 Phospholipase D1 and neurogenesis of neural stem cells CDC42 STAT3 HPCA PC PMC9253713__AF1 SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway LATS1 SUFU FACL4 NF2 PMC6738809__F6 Mechanisms involved in vitamin D-mediated immunomodulation of neutrophils NR1i1 CYP27B1 MAL SOCS3 TRAF6 MYD88 PMC8842010__F4 Identifying individualized risk subpathways reveals pan-cancer molecular classification based on multi-omics data PIK3CA RAF1 SOS1 VAV2 IL3 IL3RA PIK3R2 PPP3CC MAPK3 FGFR2 NGF BCL2L1 RALA FGFR4 FGFR1 RALBP1 MAPK1 VAV3 VAV1 HRAS TIAM1 PRKACG SOS2 PAK1 CDC42 BAD PIK3R5 PIK3R3 EGFR AKT3 PPP3R1 RAC3 RALB CSF2RB MAP2K4 INSRR CHUK JUN PPP3R2 KRAS RAC1 ARAF NFKB1 IKBKB PDGFRA RELA NTRK1 NFKBIA FGFR3 MAP2K1 MAP2K2 PMC3855094__F13 Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects HGF TGFA INS IRS1 PMC9301819__F5 Atopic dermatitis and Psoriasis vulgaris -specific DEGs segregate discretely based on unbiased pathway and network analysis GABARAPL1 SOS1 FANK1 THADA KLRB1 SLC5A3 ODF2L CD7 LONRF2 PNRC1 NAP1L4 CRIP1 CD99 PPDPF MFHAS1 SPOCK2 FYN IL17RB AHNAK SOX4 LAG3 ZFP36 CCRL2 IFITM2 SYNE2 IFITM1 TGFBR3 CTLA4 RPS26 YPEL2 RPL36A NBAS PRKX NRIP3 CPM PLP2 TSHZ2 TWIST1 MMP25 ITM2C METRNL TIMP1 TNFAIP3 CTSH PTMS SFXN1 TUBA1B SNX9 PTPN13 TRPS1 GBP5 BTG1 RPL17 TMEPAI F2R CLU ARHGEF12 MGAT4A CCR6 CEBPD ARHGAP21 HEL-S-66 ISG15 CEBPB GNLY BIRC3 IL17F GALNT1 ACTG1 ZFP36L2 UBC JUN CD2 CXCL13 LPCAT2 B3GALT2 ANXA1 RBPJ GATA3 FTH1 SLA2 LMO4 CSGALNACT1 CLEC2B DAPK2 TNFSF10 CHN1 PMC2864813__F4A Substance P in Polymicrobial Sepsis: Molecular Fingerprint of Lung Injury in Preprotachykinin-A−/− Mice CCL13 IL1RN SAA2 S100A8 FPR1 PTPN11 SOCS3 LCN2 MMP9 S100A9 CCR1 IL1B PMC8842010__F6 Identifying individualized risk subpathways reveals pan-cancer molecular classification based on multi-omics data CDC2 HPSE JUND MAK APC BRAF EVI1 SMAD4 IQGAP1 MYT1 MYC FLNA CTNNB1 PKMYT1 PRKDC CREBBP EP300 NLK CCND1 YWHAZ DAAM1 PMC7156871__F3 MicroRNA (miR)‐302/367 family participates in networks that regulate cancer hallmarks CDC2 BAX EGFR MCL1 DCUN1D1 IGF1R MICA SDC1 RYR3 LATS2 MTDH NR2F2 CCND2 E2F3 RAB23 MICB CXCR4 CCND1 PMC4139671__F5 Wnt/Beta-catenin signaling pathway APC GSK3B LEF1 CTNNB1 PMC3283604__F6 TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice TSC2 TSC1 IL7R MTOR PMC8157020__F1 Novel Target Opportunities in Non-Metastatic Castrate Resistant Prostate Cancer MTOR PMC5905598__F4 Genes of complexes coding for the mitochondrial oxidative phosphorylation and tricarboxylic acid cycle (TCA) NDUFB8 NDUFB5 FH NDUFA9 COQ3 NDUFA6 CS TIMMDC1 SDHD C2 ME2 MDH2 NNT PMC8157020__F2 Novel Target Opportunities in Non-Metastatic Castrate Resistant Prostate Cancer STAT3 FYN FZD2 IL6 PMC4732299__F5 Alterations in the levels of metabolites and mRNA transcripts that are crucial to energy metabolism in NAF-1(−) MCF-7 cells ACLY HEL107 CRAT NAF1 ACO2 HEL-S-133P SCD FASN GIP ME1 ECI2 ME3 PCK2 ACACB PIG59 ACADVL MDH2 PMC10572209__F7 Molecular pathways in Hep3B cell line MAFK BAD PTEN INS CDK4 PMC11397714__F3 IFN signaling activates the JAK-STAT pathway, leading to the transcription of genes involved in the immune response (Created with https://www IFNK STAT1 IFNGR2 IFNGR1 IFNLR1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 IRS1 PMC6027339__F2 Chronic active BCR signaling in lymphoid malignancies CD79B SYK CD79A BTK BCR PLCG2 BLNK CD19 LYN PMC4819199__F7 Intestinal Insulin Signaling Encodes Two Different Molecular Mechanisms for the Shortened Longevity Induced by Graphene Oxide in Caenorhabditis elegans PMC4693877__F2 Bacterial components that affect innate and adaptive immunity in the intestine PDC AHR PMC11848412__F5 A, Schematic illustration of how calcium dysregulation in the aging association cortex leads to activation of calpain‐2 and an exacerbation in sporadic AD pathology RYR2 CDK5 LIMK1 ROCK1 APP PMC11397714__F1 Canonical TNFA signaling pathway activates NFKB through TNF receptor binding, involving TRADD, RIP-1, and the IKK complex, leading to the transcription of various genes that are involved in the immune response (Created with https://www TAB3 RELA PMC6417013__F1 Main aspects of folate receptor signaling and C1 metabolism discussed during the meeting MTHFD2 STAT3 SHMT1 HEL-S-51e PMC11397714__F2 IL-1B signaling pathway activates NFKB and MAPKs through the IL-1 receptor, leading to the transcription of genes involved in inflammation and immune responses (Created with https://www MAP3K7IP1 IRAK1 TRAF6 MYD88 PMC9017388__F6 SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells BAD EIF4EBP1 PIK3R1 PPP2CA MTOR PRKAA1 EIF4E MAPK3 TSC2 EIF4G1 PDPK1 RPS6KB1 PRKCA PRKAB1 AKT1S1 PMC8476782__F2 Cellular Prion Protein in Cancer Biology: A Potential Therapeutic Target FYN SP1 SATB1 MMP11 NOTCH1 PMC2596750__F8 TNFR1 and LTBR ligation-induced signaling in vascular EC CXCL12 LTBR CXCL2 TNF PMC7225294__F11 Proposed model of action and mechanism by which CVB3 infection causes cardiomyocyte death MAVS DSG2 IFNB1 ISG15 DSC2 CTNNB1 PMC10873402__F5 JAK-STAT signaling pathway PRLR IFNA7 IFNE STAT3 PIK3CA IFNA8 RAF1 IFNA14 SOS1 IFNA16 IFNA10 PIK3R2 IF1AA9 PIK3R1 EPO IL21R IL6R IL-21 IFNG STAT1 EPOR OSMR GHR IFNL2 IFNGR1 STAT2 IRF9 IL7R IL22RA2 IFNA2 IL10RA GHB3 TSLP SOS2 THPO IL12B IL10RB IL20RB IL15 CSF2RA LEP IFNW1 AKT3 IL5RA IL2RG IL2RA GH1 IL11RA IFNK IL11 IFNA17 IF1IB1 IL10 IFNLR1 IL12A LEPR IL4 IL2RB IL24 IL7 STAT4 IFNB1 TYK2 OSM IL3 PIK3CD JAK3 IL3RA IL15RA IL22RA1 IL17D STAT5B IF2D CSF2 IFNA21 HRAS CNTFR CTF1 IL9R IFNAR2 IFNAR1 GRB2 IL23R IL12RB1 IFNL3 PIK3R3 MTOR CSF3 CSF3R MPL IFNGR2 CSF2RB IL13RA1 IL2 IFNA1 CRLF2 IL9 IL27RA IL13 LIF IFNA4 PTPN11 IL20RA IL6 IL5 PTPN6 CNTF PRL IL6ST JAK1 STAM2 IL13RA2 IL23A PMC10873402__F4 Enrichment analysis for leading target genes PSG11 MSC PMC8846289__F1 Immune Reconstitution Following Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: A Review on Behalf of the EBMT Autoimmune Diseases Working Party IFNG MICA PMC4135580__F7 Working model for the PEX5L-PEX7-mediated import pathway PEX7 PEX6 PEX5 PEX16 PMC2737901__F1 Putative biosynthetic pathway of PUFAs in Mortierella alpina 1S-4 COCH GLA TNLG7C PMC5391973__F4 The immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity CD40 MOK JUN MAP3K7IP1 TIRAP IL16 CD14 IRF3 IRF7 LBP IL1B MYD88 PMC8065571__F1 Schematics of the eicosanoids synthesis pathway for the production of prostanoids (Prostaglandins—PGs, Prostacyclin and Thromboxanes—TXs), Leukotrienes (LTs) and resolving mediators including D- and E-series resolvins (Rvs), protectins and maresins LTB LTA COX1 COX2 PMC4837237__F7 A simplified overview of the ectodysplasin/EDA‐receptor/nuclear factor kappa B (EDA/EDAR/NF‐KB) pathway EDARADD EDAR TNLG7C PMC3051261__F11 Schematic Models of Tap46/Tap42/A4 Functions in TOR Signaling Pathways in Eukaryotes.(A) TOR signaling in yeast RPS6 MTOR EIF4E PMC8706757__F2 Necroptosis in disease and treatment FAS TRADD MLKL TAB3 RIPK3 TLR3 C2 TLR4 TRAF5 RIPK1 TRAF2 CYLD FADD PMC1964512__F3 Type I IFN innate immune response to adenovirus-mediated IFNG gene transfer contributes to the regression of cutaneous lymphomas SNAP23 CXCL9 DBP CCL22 PLSCR1 SOCS2 GAS2 CCL2 RORA CORT STAT1 SP100 CASP4 FGF9 OAS1 IFNA1 OAS2 CCRL2 FAT10 NMI XCL1 AIM2 SP110 IRF7 LGALS9 RSAD2 CXCL10 MNDA NCR3 CCKAR CCL20 PMC8372151__F3 Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease—A Pediatric Perspective FGFR4 PTH FGF23 PMC9569955__F7 Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation TBK1 MAVS MAP4K1 IFIT3 BLNK IRF3 TRAF3 TRAF6 STAU1 ABCF1 TRIM25 BCR UBE2F VCAM1 PMC6027339__F1 Oncogenic MyD88 mutations activate the canonical NFKB pathway MAP3K7IP1 IRAK1 TRAF6 IRAK4 PMC7765482__F8 Canonical pathways identified from protein co-expression network CDH2 MAPK1 IFNGR1 TGFB1 HEL-S-67p SERP1 SNCA MARK1 PRKCB HAVCR2 HEL-S-71 MAP2K4 PDPK1 USP2 IFNAR1 PRKCA BCL2 LYN GRB2 SRC CRLF2 BIK CP BIRC3 PMC3612391__F2 Role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development SEMA3E PMC5747488__F13 Parapoxviral virion protein targets the retinoblastoma protein to inhibit NFKB signaling MAP3K7IP1 TRADD TAB3 TRAF2 PMC3731808__F6 Comparison of gene expression changes in human bladder cancer and our mouse model based on KEGG pathway analysis EGF HEL-S-79 THBS1 CDKN2B VEGFA MYC KRAS MMP11 HRAS RB1 CDKN2A EREG CDKN1A MMP3 FGFR3 MAP2K2 MDM2 CCND1 CDK4 PMC5790345__F5 PD173074 inhibits the signal pathway downstream of FGFR1 in ESCC STAT1 FGFR1 MTOR PMC4752998__F1 Epithelial/mesenchymal status of MCs is due to the balance of signals delivered by multiple receptors STAT3 SMAD1 HGF DKFZp781O1323 SMAD2 BMP7 RHO IL1B PMC3429478__F1 Development of Quinoxaline 1, 4-Dioxides Resistance in Escherichia coli and Molecular Change under Resistance Selection TG FES PMC5611863__F1 Landscape of new drugs in lymphoma SYK CD79B JUN CD79A ERBB4 TXK EGFR CARD11 JAK3 BLNK BMX CD19 FOS BLK TEC BTK BCR ERBB2 ITK LYN BIK PMC4185881__F1 Formal Modelling of Toll like Receptor 4 and JAK/STAT Signalling Pathways: Insight into the Roles of SOCS-1, InterferonB and Proinflammatory Cytokines in Sepsis CSA2 TBK1 MAP3K7IP1 TLR4 MAL CD14 IRAK1 IRF3 TRAF6 LBP MYD88 PMC8997162__F1 Molecularly Targeted Therapy towards Genetic Alterations in Advanced Bladder Cancer ERBB3 EGFR FGFR4 FGFR1 ERBB2 FGFR3 PTEN FGFR2 PMC8976706__F4 Decellularized extracellular matrix mediates tissue construction and regeneration LATS1 LATS2 PMC4410875__F3A Differential microRNA expression tracks neoplastic progression in inflammatory bowel disease-associated colorectal cancer PTEN CTNNB1 PMC3633815__F1 MTOR signaling pathway RHEB TSC2 TSC1 SGK1 ULK1 RHO PMC2674738__F1 Circulating blood monocytes adhere to activated endothelium at sites of disease or injury LPA CCR2 PC PMC6373401__F1 Neuroprotective mechanisms of antidiabetic drugs in the context of Parkinson’s disease dementia IDE IL1R1 IGF1 MTOR BDNF PMC8812204__F2 Dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke NBR1 LAMP2 ATG16L1 ATG12 ULK1 TFEB ATG14 SQSTM1 MTOR RAP2B ATG5 PMC8812204__F1 Dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke ATG101 RHEB ULK1 ATG14 BNIP3 PMC7330432__F1 MicroRNA-4500 Inhibits Migration, Invasion, and Angiogenesis of Breast Cancer Cells via RRM2-Dependent MAPK Signaling Pathway PCNA RRM2 PMC11547832__F8 DOE is involved in the Akt signaling pathway to regulate protein synthesis and lipogenesis UCP1 MYH2 IRS1 PMC8432143__F2 Moving towards clinical trials for mitochondrial diseases TFAM POLG PARP1 POLRMT PMC7012475__F1 Monocytes in sickle cell disease TF MIA PIGF TLR4 VCAM1 PMC6486704__F2 Chemoautotroph Ca NONO GNS NDP PMC5615340__F5 Crosslinks between integrin and wnt signalling GSK3B HEL-S-28 CTNNB1 PMC2909359__F8 Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest FOXD3 DCT ITK CSF1R PMC8889909__F2 Physiological and Pathophysiological Roles of Metabolic Pathways for NET Formation and Other Neutrophil Functions HEL107 RPE PMC9478117__F8 MiR-33a-5p/CROT axis mediates ovarian cancer cell behaviors and chemoresistance via the regulation of the TGFB signal pathway TGFBR2 CROT SMAD2 SMAD4 TGFBR1 PMC8445727__F8 Active Ingredients and Potential Mechanisms of the Gan Jiang-Huang Qin-Huang Lian-Ren Shen Decoction against Ulcerative Colitis: A Network Pharmacology and Molecular Docking-Based Study BAX EGF BAD HGF AXL VILL PMC10610499__F5 Interplay between EVs and the TLR4 signaling pathway in the context of HCC HMGB1 TLR4 EGFR S100A10 PMC11990295__F5 Anthocyanin in modulating PI3K/Akt/FOXO pathway in obesity FOXO1 GCK PMC10610499__F3 Liver manages a complex antigenic load from the blood, relying on immune tolerance mechanisms and mainly LPS tolerance TLR4 TRAF6 MYD88 PMC4515857__F3 PTEN localization and interactions with representative partners MC1R APC PTEN CENPC PMC10610499__F2 TLR4 downstream signaling pathways TLR4 CD14 IRF3 IL6 TRAF3 TRAF6 LBP MYD88 PMC5446300__F4 T-Lymphocyte Homing: An Underappreciated yet Critical Hurdle for Successful Cancer Immunotherapy CD44 IFNG CXCR3 CXCR1 CXCL1 VCAM1 IL8RB TNF PMC3898353__F1 Complement activation pathways MASP1 C6 CD59 C7 HEL-S-62p CFI C2 CFD CFH C9 VTN CR1 PMC3410851__F9 Multiple Roles and Interactions of Tbx4 and Tbx5 in Development of the Respiratory System SPRY2 SOX9 BMP4 TBX5 TBX4 FGF10 WNT2B FGFR2 PMC8522100__F2 Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing ALK NTRK1 BRAF NTRK3 RET PMC11672291__F7 The potential mechanism by which intracellular PC capsules exert anti‐inflammatory effects by inhibiting apoptosis BAX COX2 PC UNK PMC4232400__F5 E2F2 Transcription Factor Sustains Hepatic Glycerophospholipid Homeostasis in Mice PTDSS2 CHPT1 PTDSS1 LPCAT3 PEMT PCYT2 CHKA PISD PMC6920321__F2 NFKB Signaling Pathway(Left) Canonical pathway of NFKB activation CD40 STAT3 LTBR BCL10 EGFR RELB REL TNF TRAF2 MYD88 PMC3815777__F2 Putative intracellular cascades activated by cyclic di‐nucleotides MAVS TIRAP TLR3 TLR9 IRF3 TLR7 TRAF6 TYK2 PMC4730273__F3 The tryptophan (TRP) metabolic pathway HEL-S-90n KYNU KMO HAAO PMC11464522__F2 Molecular mechanism of ferroptosis in RCC TF MLYCD SLC3A2 OGT KLF2 PDIA4 KEAP1 GPX4 LPCAT3 FACL4 AIM2 SLC7A11 DPP9 TIEG2 STEAP3 DPP4 ATF4 PMC11464522__F1 Ferroptosis TF SLC3A2 STEAP3 GPX4 LPCAT3 FACL4 SLC7A11 PMC11464522__F4 Molecular mechanism of ferroptosis in BCa TF SLC3A2 PPARG GPX4 LPCAT3 FACL4 HEL-S-89n SLC7A11 PCBP1 ST6GALNAC6 PISD EMP1 STEAP3 PHGDH LACTB HEL-S-102 WTAP FLRT2 PMC11464522__F3 Molecular mechanism of ferroptosis in PCa TF SLC3A2 HNRNPL GPX4 SOX15 LPCAT3 FACL4 CEMIP SLC7A11 MTOR SGK2 DECR1 RB1 IFNG STAT1 STEAP3 PHGDH TFEB PMC7484992__F1 Signaling pathways activated by CXCR4 CXCL12 ACKR3 MTOR SRC PMC2860937__F1 Caveat mTOR: aberrant signaling disrupts corticogenesis RHEB BRSK1 PTEN MTOR EIF4E PMC8533503__F2 Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention UCP2 TFAM NAMPT PMC4302085__F1 Networking of the PI3K/Akt/mTOR signaling pathway RHEB EGF RICTOR EGFR PTEN IGF1R MDM2 MTOR CCND1 PMC3441384__F4 Nanoparticle-induced autophagy ATG12 MTOR ATG5 PMC2858611__F3 Depiction of the “Reelin signalling in neurons” pathway generated by Ingenuity DAB1 ARHGEF9 FYN ITGB1 VLDLR MAPK8IP1 APOE CRKL GSK3B LYZ APP PMC4302085__F2 Proposed mechanisms accounting for resistance to inhibitors of the PI3K pathway EGFR IGF1R MTOR KRAS IRS1 PMC6480472__F1 Diagram of microRNAs and their involved pathways to cancer hallmarks STAT3 CD80 ROS1 FAS HEL-S-133P EGFR PTEN MTOR CTLA4 CKS1B ZEB2 MDM2 GRB2 PMC8905141__F5 Transcriptomic and Metabolomic Analyses Reveal the Differential Regulatory Mechanisms of Compound Material on the Responses of Brassica campestris to Saline and Alkaline Stresses ACLY HPD SDHB FH PMC6714206__F7 Mechanism of PB2 on the protective effect in liver fibrosis SMO VEGFA PMC2238789__F4 Neuronal pathway containing proteins found in Lewy bodies TH C7 NPC1 MAP1B CYCS SNCA MAP2 NEFL NEFH SYP CLU HEL-S-102 NFKBIA CALB1 HEL-S-44 PMC2238789__F3 Hypothetical ‘super pathway’ not stratified for cell type illustrating known direct interactions between the 892 PD priority genes (regulation, expression and promoter binding only) CDC42 TF HEL-S-103 TH GNAO1 VAMP2 GEM GSK3B NEFL ADAM23 ARHGEF9 SYT3 PCSK1 SLC6A3 NAPG RTN1 ACHE AMPH SNCB CACNA1B SNCA RELN NEFH RAB11A SNCG DLD SNAP25 YWHAZ PMC3571341__F12 Proposed model of M-CSF-mediated organization of the osteoclast cytoskeleton SYK VAV3 GIP PMC2238789__F2 a Cell processes predicted to be influenced by the top up-regulated priority genes (164 genes showing a differential expression >1 log2) based on in silico analysis employing the ResNet database (PathwayStudio 5.0, Ariadne) NLN MAF BOK RELN ID3 CP PMC7820501__F4 Summary of the molecular processes during COVID-19 infections that are affected in DS TMPRSS2 STAT1 IL10 RNASEL CXCL10 FURIN ACE2 RAC1 PMC2238789__F5 Interactions of known PD genes (marked yellow) with the priority genes of this study TH SNCB THY1 SNCG SYP EN1 SNCA PIN1 PMC12066314__F9 Proposed model showing that apigenin promotes pigmentation through the c-KIT/Raf-1/MAPK/CREB signaling pathway CDC42 MLPH RAB27A GRB2 IRS1 CRTC1 PMC8222328__F4 Identification of biological pathway and process regulators using sparse partial least squares and triple-gene mutual interaction POR CAD PMC8222328__F2 Identification of biological pathway and process regulators using sparse partial least squares and triple-gene mutual interaction CORT CAD ZFP1 GLS ATM PMC11586126__F4 CLACs are most significantly enriched in neurological pathways, including (A) glutamate receptor signaling pathway and (B) axon guidance signaling pathway ROBO2 TH MYOG NEUROD1 HEL-S-20 ROBO1 KIN ASCL2 ZIC2 ZIC3 PMC3762983__F2 Example of a pathway reconstruction experiment TGFBR2 BMP15 BMP10 SMAD2 SMAD4 BMP5 PMC4891133__F7 Sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met SUFU SHH SMO PMC7859355__F8 Schematic depiction of our proposed model of the role of ROS in the regulation of FGF2-induced AKT phosphorylation in hPSCs FGFR1 PTEN FGF2 PMC3782205__F2 Nephrin-adaptors complex FYN CD2AP TRPC6 PMC11007890__F5 Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma MMP7 HDAC1 STAT3 APC GSK3B EZH2 HDAC2 SET PMC8051677__F6 Harnessing the Benefits of Neuroinflammation: Generation of Macrophages/Microglia with Prominent Remyelinating Properties ACLY TXNDC12 HMGCL CTSH CTSS CS HEL-S-97n GLRX SLC16A3 HEL-S-99n ACAT1 HEL-S-128m ETFA PRDX3 GNPDA1 AK2 HEL-S-2a PRDX5 HEL-S-32 SRXN1 MDH2 HEL-S-26 HEL-S-44 HEL-S-114 ACO2 HEL-S-133P ARG1 IMPDH2 HEL-S-30 PCK2 PDHA1 GSTM1 HEL-S-130P EEF2 HEL-75 PMC9334851__F1 Cross-Activation of Hemichannels/Gap Junctions and Immunoglobulin-Like Domains in Innate–Adaptive Immune Responses CD40 PANX1 BCR CD69 CD46 CD19 CD47 HEPACAM PMC6290138__F2 Hypusine–polyamine pathway in human neuroblastoma SMS SRM SMOX PAOX DOHH MAT1A DHPS PMC4164328__F3 Intracellular pathway associated with IGF1R activation IGF2R IGF1 IGF1R MTOR INS IGF2 PMC4164328__F2 Intracellular pathway associated with GHR activation in hepatocytes IGF1 EGFR GHR PMC8516344__F4 Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation CSA2 AKAP9 PMC8516344__F3 Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation SPRY2 RYR2 BDNF PMC7699713__F1 Redox Potential of Antioxidants in Cancer Progression and Prevention GRB2 UNK PMC8487963__F1 MDS and current therapeutic options IKZF1 EPOR SMAD2 EPO PMC7699713__F2 Metabolic regulation of antioxidants: Highly proliferative cancer cells rely on glycolysis to meet its exceedingly high energy demands TIGAR HEL-S-26 PMC9356074__F1 NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism NNMT PNP NRK HEL-S-90n NADK NAMPT PMC4942931__F9 Pathway analysis using IPA software suggests B3-adrenergic receptor signaling activation in T1D-MSCs, with upregulation of several downstream molecules ADRBK1 STAT3 GRB2 SRC GRK4 PMC5638116__F3 Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer CDC42 EGF EGFR HSF1 MDM2 MTOR MYC RALBP1 PMC5638116__F2 Mechanism of synergistic action of VCN-2 and docetaxel (DTL) CDC2 BAX PCNA EGFR SHH IGF1R CCNB1 CYP3A4 CCND1 CDK4 PMC8118237__F1 Intracellular and intercellular iron trafficking in the tumor microenvironment CD44 IFNG FLVCR2 SLC7A11 IL6 PMC6540260__F1 T-cell suppression and immune checkpoint blockage in tumor and organ rejection CD80 APC JAK3 MTOR PMC10669226__F4 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages signaling pathways is predicted to be upregulated in EVPs from aged animals MAPK4 IFNG STAT1 NCF2 SIRPA MARK1 TNF PMC9445052__F7 Inhibition of mTOR in bovine monocyte derived macrophages and dendritic cells provides a potential mechanism for postpartum immune dysfunction in dairy cows NOS2 CD80 IL10 CSF2 CSF1 IL12A IL4 MTOR IL6 TNF IFNG IL18 CD163 IL12B ARG2 PMC11566422__F3 ENO1 and its targeted therapy in tumors CD44 MMP7 SOX2 SIRPA FGFRL1 CMTM6 ENO1 FAP SRC CCND1 CD47 CTNNB1 PMC11566422__F2 ENO1 and its targeted therapy in tumors CD44 MMP7 SOX2 ENO1 CCND1 CTNNB1 PMC5983129__F7 Cisplatin treatment to the induction of apoptosis ATF3 CDK2 ATF4 PMC3942282__F1 The molecular mechanisms and pathways of BBR in reducing oxidative stress and inflammation UCP2 NQO1 RHO PMC10669226__F3 Cardiac Hypertrophy Signaling pathway is predicted to be upregulated in EVPs from aged animals JUN MAPKAPK2 RPS6KA1 ATF2 MTOR IL6 RHO IRS1 MAP3K7IP1 IGF1 RPS6KB1 ADSS GRB2 PMC2767105__F2 Intracellular ascorbate (Asc) modulates redox-sensitive signaling pathways in microvascular endothelial cells during sepsis IFNG STAT1 IRF1 PMC2747759__F1 Monoclonal antibodies in the treatment of pancreatic cancer BAX FADD PMC8770286__F2 Crosstalk Among YAP, LncRNA, and Tumor-Associated Macrophages in Tumorigenesis Development LATS1 LATS2 SIAH1 SIAH2 PMC8342713__F7 Inhibitory mechanism of APG-1252 and gemcitabine against nasopharyngeal carcinoma STAT3 PMC8277227__F1 Interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis HMGB1 IL1B MYD88 PMC5732353__F4 Schematic representation of DAPs associated with theanine (A) and flavonoid (B) biosynthesis GLS GC F3 PMC5932588__F1 Molecular mechanisms that connect cellular junctions to the Hippo pathway MOB1A CAD LIMD1 PATJ CRB3 AMOT ZYX PALS1 PMC4107103__F6 Hypothetical model of molecular determinants of CLL cell survival, proliferation and migration in the PB, BM and LN microenvironments SYK CXCL12 BATF CXCL13 BCL2A1 FCER2 CCL3 RELB IL6 CD44 BTK BCR CCND2 RELA CCR7 CXCR5 TRAF1 CXCR4 TRAF2 PMC8533985__F7 Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model ROCK1 MSC ARHA PMC5299404__F4 Mediterranean versus Red sea corals facing climate change, a transcriptome analysis HEL114 EGFR MAP3K7 ARHA NLK NOTCH3 SRC PMC9322955__F3 Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts ATR CDK6 ATM MDM2 CXCL10 CDK4 PMC6628600__F5 UPLC-Q-TOF-MS profiling of the hippocampus reveals metabolite biomarkers for the impact of Dl-3-n-butylphthalide on the lipopolysaccharide-induced rat model of depression ANGPT4 GPR171 MTOR CP PMC9322955__F2 Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts SMAD2 SMAD4 PMC4117527__F5 Genome-Wide Analysis in Human Colorectal Cancer Cells Reveals Ischemia-Mediated Expression of Motility Genes via DNA Hypomethylation KLF4 AP1G1 SMAD2 KDM3A RPS6KA1 PTEN FBXW7 GDF15 LDLR UBE2D3 NRAS CSNK2A1 EPC1 SPRY1 APOC1 TMEM158 ADM RBBP6 PLAUR APC CRY1 KHSRP IL4 GKAP1 TNF CHI3L1 TACC2 IGF1 PFKP CUL4B LAMB3 HSPA4 FPR2 PIGR WDR5B PMC9322955__F1 Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts KEAP1 TNF PMC6199368__F5 Hypothetical model to sensitize GC XPA BAD MCL1 XPC PMC8185927__F1 Overcoming the UCB HSCs –Derived NK cells Dysfunction through Harnessing RAS/MAPK, IGF-1R and TGFB Signaling Pathways ZAP70 IGF1 SMAD2 SMAD4 TPO PTEN IL6 GRB2 CD34 PMC11277918__F2 cGAS-STING can transform a cold tumor into a hot tumor and promote tumor cell apoptosis IL10 CGAS TGFA IL6 IL1B PMC10815231__F5 Graphical summary of the mechanisms of action of microRNAs and lncRNAs in renal fibrosis TEC MTOR PFKM PMC20445__F6 Schematic diagram showing steps in the signaling pathway by which P CFTR SRC LBP PPY PMC8304747__F5 Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration NMNAT1 NMNAT2 FOXP3 NMNAT3 PMC4359951__F3 Genomic analysis of metastatic cutaneous squamous cell carcinoma ATR STK11 HGF EGFR CARD11 BRAF PTEN CDKN2B MTOR MYC RB1 CDKN2A CDK6 NF1 ATM NF2 CCND1 NOTCH1 CDK4 RASAL3 ERBB4 dik KIT NOTCH2 TP63 NFKBIA CREBBP FGFR3 EP300 PMC8304747__F2 Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration ACLY ASS1 ASL GLS HEL-S-133P FASN PMC8730355__F1 Contribution of the cardiomyocyte to tissue inflammation in cardiomyopathies CGAS CXCL1 CCR2 PMC10385272__F5 Key gene expression patterns in carbohydrate metabolism and lipid metabolism pathways in the pulp and seeds of Symplocos paniculate ACLY LPA FH OGDH PMC6857099__F4 BRD4 is involved in the transforming growth factor B (TGF-ß)/SMAD signaling pathway BRD4 SMAD2 SMAD4 PMC10815231__F2 Therapeutic implications of miRNAs and lncRNAs in AKI GOLPH3 NR1C1 RUNX1 NLRP3 HK2 RIPK1 HIPK1 CCL2 PMC10815231__F4 Graphical summary of the mechanisms of action of miRNAs and lncRNAs in DKD RAB3B STAT3 EDEM3 EGR1 FIS1 LIN28A ROCK2 MTOR NOX4 ACR PMC10815231__F3 Action of ncRNAs in CKD TSC1 NFAT5 MTOR PMC6370815__F7 KEGG cell cycle pathway analysis PCNA CDC6 STAG1 SMAD2 SMC3 SMAD4 MYT1 ME1 ORC3 SKP2 ORC2 RAD21 CDK7 MALL E2F4 CDK2 PMC7427467__F5 IL-27 tips the balance of immunity toward L IFNG IL10 CCL2 TNF PMC7504502__F3 Feedback loop on BMP4 pathway mediated by miR-125a/b and miR-23a-24-27a during both the exit of mESCs from naïve state and their neuroectodermal differentiation SMAD1 DKFZp781O1323 BMP4 PMC3628288__F2 Diagram of two potential molecular pathways of serrated neoplasia BRAF KRAS PMC26984__F1 Proposed pathway of EGF-induced cell proliferation of ER− breast cancer cells EGF CDK6 PI3 EGFR CDK4 PMC9608775__F1 MicroRNA-383: A tumor suppressor miRNA in human cancer ROBO3 CENPF HMGA2 CASP2 SOX11 IRF1 PAX6 CIP2A PRDX3 TIPRL PARP2 ZEB2 RBM3 CCND1 PMC9189572__F11 Longitudinal intronic RNA-Seq analysis of Parkinson’s disease patients reveals disease-specific nascent transcription MAX JUN C2 TFEB ATF4 OPTN PMC6593428__F7 Model describing the mechanism regarding the inhibitory effect of IFITM2 on Type I IFN signaling pathway TBK1 IFITM2 IRF3 PMC9189572__F10 Longitudinal intronic RNA-Seq analysis of Parkinson’s disease patients reveals disease-specific nascent transcription SVIP RBX1 CASP12 SKP1 ATF4 ATP6 WFS1 TRAF2 PMC8786807__F7 Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell FKBP4 NR3C1 PMC6561916__F4 Stem cell-related signaling pathways in miR-25 overexpressing LX-2 cells CSNK1G2 DTX2 DTX3 GSK3B PRKCZ SMAD4 MAPK9 MYC PPP2R5E FRAT1 PSENEN MME FBXW2 CTBP2 CSNK1E CCNE1 FGFR1 CSNK1G1 CSNK2A1 SMO NOTCH1 CDH2 CSNK1D TUBB FURIN PRKCI HEL-S-68p FOSL1 PSEN2 AXIN1 WNT3 SNW1 CDC42 ADAR CXCL12 NR1C2 PPP2CA PPP2R5C PRKCH BTRC MAML3 COL1A1 PRKCE ADAM17 CCND2 OTX2 CTBP1 LDLR LFNG HPRT1 RAB23 GAS1 NOTCH3 DLL3 MAML2 CCND3 JUN DTX3L ARHA RBPJ RAC1 CD44 NCOR2 HDAC1 MAML1 DVL3 CREBBP NLK KAT2B PMC4351630__F6 Schematic summary of the effects mediated by RA-NPs against MPTP-induced injury in the dopaminergic (DA) nigrostriatal pathway of adult and old mice TH PITX3 PMC9317521__F3 New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC7723503__F8 Signaling pathway of CaOx-induced ferroptosis in HK-2 cells and rat renal tissues TF SLC3A2 GPX4 FACL4 SLC7A11 PMC8764312__F1 Novel Targets and Therapeutic Strategies to Protect Against Hepatic Ischemia Reperfusion Injury FYN NLRP3 TLR4 GSK3B IL6 FAM3A MYD88 PMC6521546__F5 Superimposing mTOR signaling subgraphs from KEGG and WikiPathways RPTOR MLST8 RICTOR MAPKAP1 EIF4EBP1 TTI1 CHUK EIF4E1B MTOR DEPTOR EIF4E PMC3361581__F1 Depiction of arachidonic acid signaling pathway highlighting genes measured in this study PTGDR PTGER2 PTGER3 ALOX5 PTGER1 PTGS1 ALOX15 ALOX12 PTGER4 PTGS2 PTGFR PTGIR PMC6701280__F7 IH protection against liver fibrosis SMAD4 MMP2 PMC9015122__F2 Interaction types that are not found in SULT1A1 SULT2A1 PMC5410960__F4 Rb1 pathway RB1 CDKN2A CDK4 PMC7821926__F1 Unfolded protein response (UPR) pathway BCL2 ATF4 EIF2A XBP1 PMC8066821__F2 Biosynthetic (transsulfuration) and catabolic (oxidation) pathways of H2S PHGDH PSAT1 SQOR HEL-S-64p PSPH PMC8225085__F4 Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2 KRT18 CSF1 PYCARD RASSF1 EGFR BRCA2 SFN CHAD MYC KRT19 ADAM23 CCNE1 CCND2 RARB CST6 MMP2 ABCG2 ABCB1 MGMT JUN HIC1 MMP9 TFF3 ID1 GATA3 NR3C1 HEL-S-130P BRCA1 CDK2 BCL2 PMC6074780__F1 PD-1 in T-cell activation, exhaustion and effector function.Notes: (A) T-cells are activated via (1) binding of MHC plus peptide on an APC to the TCR and then (2) binding of APC CD80/86 to T-cell CD28 CD80 APC PMC3173057__F11 Schematic view of the proposed HSP60-TLR4 signaling in response to myocardial ischemia TLR4 IRAK1 FADD MYD88 PMC2913069__F1 Interconnected pathways that cause bone marrow failure ATR TERF2 TERT FANCM FANCL FANCA FANCC FANCB FANCE RPL5 FANCG FANCD2 FANCF RPS10 RPS17 ATM PINX1 POT1 TINF2 RAD51 RPL11 DKC1 NHP2 GAR1 NOP10 TERF1 TPP1 RPS7 RPL35A RPS26 RPS24 TERF2IP PMC4291754__F4 Cell signaling pathways are allosterically elicited by the activated receptor tyrosine kinase (RTK) FOXO1 MDM2 GRB2 PMC7901191__F9 Wnt signaling pathway associated with FZDs SIAH1 ROCK2 APC LRP5 SMAD4 LRP6 RYK ARHA CTNNB1 BAMBI RBX1 SOST INVS RNF43 NOTUM CER1 ZNRF3 SKP1 NLK GPR49 DAAM1 LGR6 PMC2583931__F1 Migrating D-loop model of recombination MSH4 RAD52 RAD50 RAD51 SPO11 MRE11A FBXO18 PMC10814950__F8 Key signalling pathways targeted by a combination of PI3Ki (PIK-75) and CDKi (dinaciclib) CDC2 RB1 CDK2 MTOR CDK4 PMC6347506__F6 Integrative regulation of physiology by histone deacetylase 3 TF HDAC3 IFNG AMPD3 TBL1X BCAT2 TBL1XR1 GPS2 PMC4504805__F1 Schematic of BH4 de novo synthesis, salvage, and regeneration pathways and its role in 5-HT synthesis DHFR TPH2 AKR1B1 PMC6347506__F5 Integrative regulation of physiology by histone deacetylase 3 TF HDAC3 TBR1 STAT3 FOXO3A TBL1X PC TBL1XR1 GPS2 PMC4029488__F2 HFPN model of extended center metabolism pathway in E PGP HPR PTS GIP POLE PMC7723674__F8 Mechanism of action of nimbolide in diethylnitrosamine and N-nitrosomorpholine induced hepatocellular carcinoma mice PCNA CCND1 CDK4 IL1B PMC4029488__F1 Basic regulation mechanisms required in the process of a cell utilizing glucose and glycogen CRP HPR PTS HP POLE PMC6347506__F2 Integrative regulation of physiology by histone deacetylase 3 TF HDAC3 PROX1 EBP TBL1X TBL1XR1 GPS2 PMC3791603__F1 Hh signaling in animals SUFU DISP1 SMO SKI PMC6347506__F4 Integrative regulation of physiology by histone deacetylase 3 TF HDAC3 SHF TGFB1 HEL-S-62p TBL1X ZBTB7B TBL1XR1 GPS2 PMC7438472__F2 Activation of the AIM2 inflammasome CGAS GSDMD AIM2 IRF1 IL1B PMC11946830__F2 Hijacking cellular pathways and oncogenic mechanisms in Cryptosporidium infections: Cryptosporidium manipulates several key host cell signaling pathways to ensure its survival and potentially contribute to cancer development CDC42 TLR4 APC RELA IQGAP1 GPT PMC5282877__F2 Signaling involved in CSCs that mediates melanoma progression IGFBP5 CITED1 BRAF NRAS NUMB SMO HIF1A IGF1R ARHA MYC NOTCH1 PMC9350720__F1 Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review MASP2 HEL-S-62p CS C4B_2 PMC8276946__F2 Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies BAX FAS FADD PMC4054791__F1 Schematic representation of the photorespiratory pathway (in black) and the three circumvent pathways designed to overcome the photorespiratory losses HEL-S-62p C2 PMC7360684__F2 Canonical TGFB signaling pathway and TGFB signaling targeting therapies SMAD2 SMAD6 SMAD4 MYC PMC3708179__F8 Enrichment of hyper- and hypophosphorylated peptides in the ERK/MAPK signaling pathway in the phosphoproteome of murine liver on treatment with high-fat versus low-fat diet CRK BAD FYN MOS NFATC1 GRB2 SRC MYC EIF4E PMC4678324__F3 Cell-intrinsic versus cell-extrinsic control of metastatic progression by miRNAs BACH1 HMGA2 RAF1 IGF1 PITPNC1 DNAJA4 APOE IGFBP2 IGF1R MERTK PMC4783254__F2 Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease TF GPX4 HEL-S-102 PMC2896712__F2 Metabolic pathway map constructed using the E-Cell RBC model PGP MGP PMC2744640__F4 Regulation of Mitochondrial Respiratory Chain Biogenesis by Estrogens/Estrogen Receptors and Physiological, Pathological and Pharmacological Implications TFAM PGC SP1 MTIF2 NRF1 PMC11087094__F3 Four most related metabolic pathways in digestive system tumors ASS1 ASL GLS HEL-S-5 OTC PC ARG1 GOT1L1 PMC8397173__F8 Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically Regulate Sporisorium scitamineum Mating and Virulence via Transcription Factor Prf1 TF PRF1 ATF1 PMC5391460__F9 NEAT1 exerts antihantaviral effects by acting as positive feedback for RIG-I signaling MAVS SFPQ IRF7 TRAF3 PMC3242749__F4 Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice HTRA2 BAX BCL2 ATF4 PMC3140140__F1 Variation in the suppressive abilities of Wnt antagonists with respect to canonical and non-canonical Wnt signaling pathways APC GSK3B LRP5 LRP6 PMC4312948__F7 Role of TRP channels in the vascular system TRPM7 TRPM2 TRPA1 TRPC7 TRPC1 TRPV1 HEL-S-11 TRPC6 TRPC3 PMC7503523__F2 Polyomavirus JC: one virus, two stories ATR RAD51 APC PML IGF1R MYC MDC1 IRS1 CTNNB1 IGF1 ATM MDM2 NF2 PMC8969174__F1 Genetic architecture of childhood BMI exhibits dynamic changes over early childhood GLP1R LEP HHIP CCNL1 MLXIPL MC4R KLF14 EHBP1L1 PCSK1 NR2A2 NPY AgRP GCK SH3GL3 NR5A2 UBE3D EFCAB8 SEC16B RIN2 CAST PYY LEPR DLG4 OPRM1 SCGB1A1 NCOR2 PLCE1 GPSM1 PTCH1 FAIM2 SH2B3 PMC9235413__F5 Site of action of the Wnt signaling pathway inhibitors that are in current or were in past clinical trials PORCN APC GSK3B LRP5 CTNNB1 PMC9235413__F3 Crosstalk between Wnt and other major signaling pathways in uterine fibrosis IGF1 LRP5 NUMB LRP6 MTOR CCND1 CTNNB1 PMC9235413__F2 Wnt signaling in mechanotransduction and extracellular matrix (ECM) alterations in uterine fibrosis APC GSK3B LRP5 LRP6 CTNNB1 PMC9235413__F1 Canonical and noncanonical Wnt signaling pathways CDC42 JUN APC ROR2 GSK3B LRP5 LRP6 RYK ATF2 RHO CTNNB1 PMC7349809__F1 Mechanisms for respiratory syncytial virus (RSV) inhibition of type I interferon (IFN) production TBK1 MAVS STAT2 IRF9 TANK IRF3 IRF7 TRAF3 STAT1 RIGI IFNAR2 IFNAR1 JAK1 TYK2 PMC6275424__F1 Ras/ERK signal transduction pathway with emphasis on p120-RasGAP interactions TCF3 RASA2 BRAF CCM1 PPP3CA RHO GRB2 SHE HAND2 PMC2667382__F8 Phosphorylation of the Translation Initiation Factor eIF2A Increases BACE1 Levels and Promotes Amyloidogenesis BACE1 ELF2 EIF2A PMC8898246__F2 Where are we in 2021 with heart failure with reduced ejection fraction?—current outlook and expectations from new promising clinical trials PGC CORIN FURIN NPPB PMC2976339__F5 Gene expression within cluster MCL2 is enriched in genes affecting NK cell-mediated cytotoxicity ZAP70 SYK FAS HLA-E LAT CASP3 HLA-B SHE HLA-C IMPACT PMC8402548__F1 Analysis of Host Immunological Response of Adenovirus-Based COVID-19 Vaccines TH IL10 IL6 APC2 PMC8089370__F1 Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment SLC3A2 LLGL2 YBX3 TUB YKT6 ATF4 SLC7A5 YAP1 PMC11087094__F4 Three greatly important metabolic pathways in digestive system tumors PGP PIG59 AGXT CYP11B2 HSD11B2 HSD17B2 PC CS PMC11762646__F6 microRNAs regulate pathways by targeting multiple genes SP1 IGF1 IGFBP5 CYP7A1 SMAD2 PTEN ABCA1 CPT1A IRS1 PMC5767248__F3 AMPAR trafficking during Alzheimer’s disease (AD): early and later phases FYN SMS GSK3B PMC8481958__F1 Immunometabolism during inflammaging GDF3 NLRP3 MTOR IL1B PMC4608483__F2 RNR regulation in S PMC6755339__F2 Main synthesis pathway of n-3 long-chain PUFA-derived lipid mediators GPR32 GPR37 FPR2 PMC8837022__F3 Isoxazole Derivative of Usnic Acid Induces an ER Stress Response in Breast Cancer Cells That Leads to Paraptosis-like Cell Death SVIP UBA2 RBX1 SELL CASP12 ELF2 BCL2 SKP1 ATF4 ATP6 WFS1 TRAF2 PMC3080176__F2 Diagrammatic representation of the top three canonical signaling pathways, proposed by the Ingenuity Pathways Analysis program, associated with differentially expressed genes in the microarray dataset TTN ATM POLE PMC5372523__F1 Nerve growth factor (NGF) and its Tyrosine Kinase A receptor (TRKA) are involved in several signaling pathways in epithelial ovarian cancer (EOC) NGF ADAM17 COX2 PMC7990367__F3 Pathways regulating cellular senescence and the SASP STAT3 STAT1 ATR CGAS TRAF3IP2 ATM IL1A MTOR GATA4 SIRT1 PMC11642960__F4 Pathway and network analysis of the proteins identified in the AR/SRF interactome FOXA1 MAK HEL-S-89n TERT KRAS NR3C1 CTNNB1 FKBP4 PELP1 HEL-S-125m HEL-S-49 HEL-S-162eP AHR ERBB2 CDC37 CDK4 PMC7963155__F4A MicroRNAs in the Cisplatin- and Radio-Resistance of Cervical Cancer PTEN PMC11642960__F6 Proposed common pathways of the SRF/AR interactome and the key proteins identified by APMS and bioinformatics TUBB4A PELP1 RAN TUBB4B PMC4860161__F1 Autophagy pathway ATG12 ULK1 MTOR ATG5 PMC4018747__F4 Pathways leading from ssDNA-bound RPA to the recruitment of an error-prone polymerase η, ι, K or Rev1 for bypass of a potential template lesion RAD18 ATR REV1 ATRIP PCNA POLK POLI POLN PMC9147761__F1 Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application BMI1 EPCAM JDP2 IL6 PMC2721253__F2 Modes of neurite growth inhibition of molecules expressed on CNS myelin and oligodendrocytes LMO4 BMP4 BMP2 LINGO1 RHO PMC107042__F1 Diagram showing the relationships among the regulatory factors governing srf transcription initiation COMP PMC6563036__F3 Proposed mechanism between mTOR Signaling Pathway, Inhibitors and Photodynamic Therapy (PDT) MLST8 TSC2 RICTOR TSC1 PTEN DEPTOR PMC6563036__F2 mTOR Signaling pathway MLST8 TSC2 RICTOR TSC1 PTEN DEPTOR PMC5860060__F4 Association network of linc-RPIA identified in co-module 1 SPTB NRCAM VASP EGFR RPS6KA2 SMAD4 NUMB RANBP9 RGMA ROBO2 EZR AGRN HLA-E EVL BCR SRGAP1 SRC RDX RPTOR TRIO NRP2 HEL70 NCOA1 AP2M1 NCOR2 NR1C1 SOS2 CREBBP EP300 PMC2822437__F1 Heterotrimeric G Proteins and Apoptosis: Intersecting Signaling Pathways Leading to Context Dependent Phenotypes BAX TNF FADD PMC4744573__F1 Standing your Ground to Exoribonucleases: Function of Flavivirus Long Non-coding RNAs DCP2 DIS3L2 XRN1 PMC8041604__F4 Mechanisms of PI3K/Akt/mTOR pathway and MAPK pathway, and inhibitors in ovarian cancer clinical development CDC42 BAD TIAM1 RIN1 PTEN MDM2 MTOR RAC1 OTP PMC10538272__F5 Irreversible repolarization of tumour‐associated macrophages by low‐Pi stress inhibits the progression of hepatocellular carcinoma COX2 CCR7 TNF CCL17 MYD88 PMC11959054__F7 Role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout SOCS1 STAT3 STAT1 SOCS3 MYD88 PMC8699560__F1 Enhancing Therapeutic Approaches for Melanoma Patients Targeting Epigenetic Modifiers PTEN CTLA4 TNF HDAC6 PMC2865177__F1 ER stress-induced apoptotic pathways BAX BCL2 ATF4 ERO1A EIF2A TRAF2 PMC8541136__F1 Heparanase Regulatory Network in Health and Disease HPSE EGR1 HGF SP1 TLR4 SP3 BRAF IL1B FGF23 PMC6721072__F5 Ca2+ toolkit in endothelial colony forming cells (ECFC) ORAI1 STIM1 TRPC1 TRPV1 PLCB2 TRPC3 IGF2 PMC7516134__F1 Zoledronic acid on the bone metastatic niche and the “vicious cycle of bone metastases” CXCL12 IL6 CXCR4 IL6R IL1B PMC6721072__F2 Ca2+-dependent activation of the extracellular signal-regulated kinase (ERK) pathway and of the Nuclear Factor of Activated T-cells (NFAT) PLCG1 ORAI1 INSR TRPC4 TRPC3 PMC8391121__F1 Invadopodia, a Kingdom of Non-Receptor Tyrosine Kinases EGF NCK1 VAV2 EGFR SRC RAC3 PMC6721072__F1 Pro-angiogenic Ca2+ toolkit in vascular endothelial cells PLCB4 PLCG1 ORAI1 INSR STIM1 TRPC4 PLCB1 TRPC1 PLCB2 PLCB3 TRPC6 TRPC3 PMC8262160__F6 Knockdown of GPSM1 Inhibits the Proliferation and Promotes the Apoptosis of B-Cell Acute Lymphoblastic Leukemia Cells by Suppressing the ADCY6-RAPGEF3-JNK Signaling Pathway GPSM1 ADCY6 PMC12207805__F8 Proposed mechanism by which L-Phe promotes liver steatosis NR1C1 BNIP3 MTOR PMC7664917__F2 Signaling pathways in ferroptosis SLC3A2 GLS GPX4 FACL4 SLC7A11 PMC2854301__F9 The Transcriptional Repressor REST/NRSF modulates Hedgehog Signaling REST SHH PMC6801086__F8 Base excision repair pathway, homologous recombination pathway, and how BER intermediates may lead to HR PNKP RAD51 BRCA1 POLK BRCA2 POLE POLN PMC3656715__F1 Hippocampal BDNF/TrkB signaling pathways that modulate depressive behavior and antidepressant responses CDC42 ARHA GRB2 MTOR BDNF CTNNB1 PMC7306092__F3 Progression of fibrosis caused by expression of ECM proteins after activation of TSP-1 CD36 SMAD4 RHO CD47 PMC8186467__F2 Bidirectional Relationship Between Cancer Epigenetics and Metabolism TET2 SLC3A2 ARID1A BAP1 BCAT1 EZH2 SLC7A11 PMC7306092__F2 Activation of pathways triggered by hyperglycemia to induce TSP-1 expression EGR1 SP1 PMC7276297__F1 Biochemical pathway of steroidogenesis CYP21A2 STAR CYP17A1 CYP11B2 CYP11A1 DHCR7 PMC7465134__F1 miRNA modulators of the p53 signaling pathway in Adrenocortical Carcinoma BAX CASP9 CASP3 MDM2 PMC10177463__F3 BRAF V600-Mutated Metastatic Melanoma and Targeted Therapy Resistance: An Update of the Current Knowledge HGF NF1 EDN1 PPP2R1B EIF3A PTEN MTOR PMC5215973__F2 Deubiquitinases in breast cancer USP25 BAX FAS SMAD2 APC GSK3B SMAD4 USP9X FANCC USP48 CTNNB1 ATG10 DDB2 USP15 POLK USP2 RELA MDM2 GADD45A CYLD PMC7465134__F3 miRNA modulators of the Wnt/Beta-catenin signaling pathway in Adrenocortical Carcinoma TF LRP5 LRP6 CTNNB1 PMC7465134__F2 miRNA modulators of the mTOR signaling pathway in Adrenocortical Carcinoma EGFR LRP5 LRP6 MTOR TNF EIF4E PMC9524263__F4 Melatonin pretreatment on exosomes: Heterogeneity, therapeutic effects, and usage STAT3 SIRT1 PMC8044947__F1 Popular signaling pathway in the research of primary mediastinal large B-cell lymphoma SOCS1 PTPN1 B2M PMC8033456__F1 STING and transplantation: can targeting this pathway improve outcomes? TBK1 CGAS APC IRF3 CTLA4 CD47 PMC6721734__F6 Molecular interplay between estrogen, EGF, and Notch signaling pathways in FTEC ciliogenesis EGF FOXJ1 EGFR PMC8924130__F4 Glioma: molecular signature and crossroads with tumor microenvironment EGFR MAK CCR2 PTEN MTOR TNF CCL2 YAP1 RB1 CDK6 LOX NF1 HEL-S-26 MGMT CDK4 PMC8924130__F3 Glioma: molecular signature and crossroads with tumor microenvironment EGFR HIF1A MTOR TNF MGMT PMC3937510__F2 Canonical Wnt signaling () FRZB DKK1 APC LRP5 LRP6 PMC7824196__F2 Autophagy regulation by the mTOR signaling pathway TRPM7 ULK1 MTOR SIRT1 PMC7824196__F1 Different steps of autophagy ATG101 NBR1 ATG3 ATG12 ULK1 MTOR ATG5 PMC2819754__F2 Transcriptional regulation of the differentiation of Th2 cells APC IL4 GATA3 PMC2819754__F1 Transcriptional regulation of the differentiation of Th1 cells IFNG STAT1 APC STAT4 FOS TYK2 PMC6257326__F2 Network view of associated proteins created within Ingenuity Pathway Analysis software for visualizing molecular interrelationships PRMT1 HEL-S-81p PSMB8 KYNU ATP1B1 GLRX TNF MAPK8 IKBKG PHB2 STAT1 GFAP SCAP2 APP ISG15 GRB2 HEL-75 BDKRB2 PMC8156203__F3 Targeting Reactive Oxygen Species Metabolism to Induce Myeloma Cell Death EN2 ENO2 GLS HEL-S-133P PHGDH HK2 PSAT1 PSPH PMC7552066__F4 JAK/STAT signalling pathway STAT3 STAT1 STAT2 IRF9 EGFR JAK3 STAT4 JAK1 TYK2 PMC7552066__F6 HPV modulation of the STAT3 signalling pathway STAT3 EGFR JAK3 JAK1 RAC1 TYK2 PMC5882332__F3 Signaling lymphocytic activation molecules Slam and cancers: friends or foes? EGF MTOR PLK1 PMC7509487__F2 How a miRNA affects cellular function: Left, repression of one critical mRNA by an individual miRNA determines cell function DUSP5 SOCS1 PTPN22 PTEN PMC3401939__F1 Targeting of oncogenes and miRNAs by retroviruses MYB PIM1 MOS SRC MYC FOS LCK PMC7830227__F2 Targeting the Hippo signaling pathway LATS1 BRD4 CDK9 PMC213796__F7 EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer SUZ12 EED EZH2 PMC2386416__F1 Illustrations of the 5 Alpha-reductase action and the pathway of androgen action on target gene expression EGF TGFA IGF1 PMC7830227__F1 Hippo signaling pathway in mammalian cells LATS1 AJUBA PMC7177258__F5 JNK signaling in the stem cell niche TNC HMGB1 SPP1 PMC7177258__F1 Regulatory system of the C-JUN N-terminal kinase (JNK) signaling cascade JUND SMAD2 CRKL ATF2 MINK1 FOS PMC8909726__F6 Translational Regulation by hnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma HNRNPF USP1 MMP9 EIF4E PMC7177258__F3 JNK signaling in normal stem cells TF WNT3A SMAD2 ATF2 GPR49 AXIN2 PMC8807551__F7 FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway BAX EGFR MTOR PMC7073129__F2 Schematic demonstration of the inhibition of the RAR pathway by BMS LRP5 WNT2B PMC7073129__F1 Interactions between retinoid signaling and the Wnt/Beta-catenin pathway on the cellular level for growth plate chondrocytes during endochondral ossification SOX9 LRP5 COL10A1 RUNX2 COL2A1 CTNNB1 PMC7430027__F7 KEGG pathway classification map of the experimental group VWF SYK BAD CD36 NPNT RBL2 VTN PTEN CD19 MTOR CHAD TNF RAC1 CD47 CD44 TSC2 RXRA BCL2 HEL-S-11 MDM2 GRB2 PMC7230796__F1 Metabolic pathway of vitamin D (based on Jenkinson 2019 and on Feldman et al NR1i1 CYP2R1 CYP27B1 CYP24A1 DHCR7 CYP3A4 CYP27A1 PMC6290262__F1 UPR activation ATF4 XBP1 PMC5819363__F1 Genomic Landscape of Pheochromocytoma and Paraganglioma MAX FH NGFR MYC CSDE1 CTNNB1 VHL RHEB TSC2 TSC1 TMEM127 NF1 SMO MDH2 RET PMC10920911__F4 Lipid metabolic reprogramming on CRC LPA STAT3 FAS NLRP3 AGPAT4 CPT1A IL1B PMC9407613__F2 New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies SP1 HEL-S-69p SMURF2 FURIN PMC10920911__F3 Glucose metabolic reprogramming on CRC STAT3 HEL-S-133P TXNIP PMC3236061__F5 Cooperation of the genes in the DNA repair cluster RAN ATR RFC1 CDC6 BRCA2 CYCS TERT ARC VCP BLM MPO CDKN2A POLG RAD17 MNAT1 ATM NF2 TDG DBF4 MSH6 UBE2V2 RAD50 TINF2 RAD51 MSH2 APC SMC1A RBBP8 RPA1 SET PARP1 XRCC3 GMNN PMS1 HEL-S-71 RAD54B RAD1 BRCA1 UBE2B APEX1 FAU MCM3 MCM2 NTHL1 REV3L BCL6 BRCC3 PMC6305530__F1 Hepatitis C virus-induced inflammation NLRP3 TLR3 IL16 TLR4 TLR8 TLR7 MYD88 PMC11608335__F1 Using Z. mobilis as the chassis for biochemical production IPP HEL-S-62p C2 PDC XDH EFS PMC9394702__F3 miRNAs as Biomarkers and Possible Therapeutic Strategies in Synovial Sarcoma CTNNB1 PMC7239885__F3 Calcium signalling pathway enriched by 48 downregulated genes encoding 23 proteins marked by stars TRDN PLN CAV3 CAV2 HRC BCR MCU CP PMC7397015__F1 Summary of experimental approaches used in identification of major mTOR signaling components RHEB TSC2 RICTOR FNIP2 TBC1D7 FLCN RAB35 MTOR DEPTOR SLC38A9 PMC10473100__F1 Necroptosis and Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Opportunities TRPM7 CASP8 TRADD STAT2 MLKL TNF MYD88 RIPK3 STAT1 TLR3 TLR4 RIPK1 MIP FADD PMC9158378__F1 Sonic hedgehog signaling pathway is susceptible to both genetic and environmental dysregulation CDON BOC PTCH1 DISP1 SHH SMO GAS1 PMC6872739__F7 Differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation CD163 CR1 RAC1 IL1B MERTK PMC10473100__F3 Necroptosis and Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Opportunities RIPK3 MLKL ABO TNF PMC7909827__F3 Paracrine interaction between Beta-cells and D-cells GAA RYR3 DDB1 HHEX CUL4B UCN3 HEL-S-11 INS SST PMC7909827__F2 Nutrient-secretion coupling in D-cells RYR3 GAL SST PMC6668790__F6 Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo SLIRP MTPAP POLRMT PMC4555078__F1 RTK signaling pathways and representative regulatory microRNAs JUN EGR1 CDK6 EGFR PTEN MTOR FOS CDK4 PMC6393639__F6 Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer CCND3 CDK6 CDK4 PMC2949191__F6 Scheme outlining the novel role of Nogo-A in controlling neuronal survival in the ischemic brain ROCK2 PTEN ARHA PMC6813780__F2 Genomics of Apicomplexan Parasites GAL HEL113 PMC4833551__F1 Pathways involved in physiological and in pathological cardiac hypertrophy actuated in calcific aortic valve disease (CAVD) IGF1 MTOR FGF2 PMC7730145__F3 Novel strategy to facilitate neuronal Cl− extrusion and EGABA by coincident NKCC1 inhibition and KCC2 activation by inhibiting the WNK-SPAK/OSR1 kinases WNK1 HEL-S-29 OSR1 WNK3 PMC7552066__F7 HPV modulation of the STAT5 signalling pathway FBXW7 EGFR IL3RA JAK3 EPO PDZRN3 JAK1 KLF13 TYK2 PMC8795890__F3 Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration SOX9 DKK1 DLL4 IL18 MSC MTOR NOTCH1 CTNNB1 PMC9604206__F2 Molecular Targets in Osteosarcoma Treatment EGFR JAG2 ADAM10 PMC8795890__F2 Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration BAX BAD BACH1 NLRP3 SOX9 IL16 MMP3 PTEN PMC9371363__F2 Negative and positive regulators of IL-4 and IL-13 signaling: SOCS1 STAT3 IL17RC PARP14 JAK3 ARG1 SOCS3 TRAF6 PARP1 IRS1 IL13RA1 JAK1 TYK2 PMC9371363__F1 Canonical and non-canonical IL-4 and IL-13 signaling pathways: STAT3 PI3 JAK3 JAK1 SRC TYK2 IL13RA2 IRS1 PMC5161243__F7 Downregulation of a GPCR by Beta-Arrestin2-mediated Switch from an Endosomal to a TGN Recycling Pathway GIP GIPR PMC7432778__F6 IL-17A has two receptor complexes, IL-17RA/IL-17RC and IL-17RA/IL-17RD, in keratinocytes IL17RC FLG TRAF6 IVL PMC5833450__F6 Melatonin-induced signaling pathway GAA BAX PC BCL2 ATG5 RAC1 NCF1 PMC7674767__F1 Extrinsic and intrinsic pathways to apoptosis BAX BAD BOK BMF HRK APAF1 BIK PMC7790578__F9 KEGG pathway details identified by FB against COPD BAX ATR FAS WEE1 ELL ATM LYN FADD PMC5735114__F2 Distribution of differentially expressed genes in astrocytes following hypoxia+ hypothermia vs ROCK2 APC GSK3B ARHA BAMBI SOST INVS SUFU NOTUM CER1 SKP1 SMO NLK RAB23 GAS1 ZIC2 PMC6599034__F2 Label propagation defines signaling networks associated with recurrently mutated cancer genes CDH2 SPEN GAA POLL ATR POLM STAR TERT MTOR PLK1 MYC BARD1 FOXM1 APLF ATM CP PMC8131521__F2 C9ORF72: What It Is, What It Does, and Why It Matters ATG101 CGAS RAB8A ULK1 TFEB WDR41 SMCR8 PMC8776063__F13 Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells AQP2 AURKA SSH1 AVP HEL-S-15 PMC7014170__F5 Schematic model illustrating the signaling pathway by which ANG reduces the inflammatory responses involving Myd88 and the nuclear translocation of NFKB in LPS induced EIU TLR4 IL4 IL1B MYD88 PMC12179876__F1 Action and potential therapeutic targets of TGF-Beta-related signaling pathway and its downstream miRNA expression in pulmonary arterial hypertension SMAD2 SMAD4 ARHA PMC6298946__F1 IL-20 receptor cytokines and their receptors IL20RB IL19 IL24 IL22RA1 PMC8718573__F3 Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers EFNB2 LTK LEP ENO2 WFDC2 PCNA EGFR GAS KIT ANXA1 B2M MTOR ANGPT4 MAGI3 PLAT AFP AGER CD33 MUC1 ERBB2 CALCA TRPC6 CCND1 PMC2553363__F2 ER stress pathway ATF4 EIF2A XBP1 TRAF2 PMC2553363__F1 Extrinsic and intrinsic pathways of hepatocyte apoptosis BAX BAD PMC9197809__F1 Research progress on drugs targeting the TGFB signaling pathway in fibrotic diseases CDC42 TRAF4 RHO GRB2 TGFBR1 PMC5297047__F6 The G-protein, cAMP/PKA signaling alterations found in the ZMEL-R1 cells ADRBK1 STAT3 RAP1A SRC GRK4 PMC6598629__F1 The supraspinal locomotor network TH PC PMC9322890__F14 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) BAX CASP9 EGF EGFR CASP3 PTEN ARHA MTOR APAF1 PMC4747023__F3 Unique genetic and epigenetic mechanisms driving signatures of paediatric diffuse high-grade glioma CORT PIK3CA PDGFRA FGFR1 BRAF PTEN IGF1R PMC4090903__F2 TLR4 intracellular signaling cascade TIRAP TLR4 CD14 IRAK1 CXCL10 IRAK4 MYD88 PMC9387879__F1 Remarkable Roles of the Receptor for Advanced Glycation End Products (RAGE) and Its Soluble Isoforms in COVID-19: The Importance of RAGE Pathway in the Lung Injuries STAT3 HMGB1 PMC6152442__F1 SRSF1 regulates SUMO conjugation to different spliceosomal proteins SF3B1 DKFZp434N041 PRPF8 PRPF6 U2AF2 CD2BP2 DHX15 SNRPB2 SMO DDX46 PRPF3 SNRPA SF3B6 PRPF4 U2SURP PUF60 SNRNP200 SF3A2 SF3A1 PRPF31 CHERP U2AF1 PHF5A RBM17 WDR57 SNRPA1 PMC5010983__F1 The (A) Wnt/Beta-catenin, (B) AKT/mTOR, (C) ERK/MAPK signaling networks that are important for oligodendrocyte development and myelination TSC2 RICTOR APC GSK3B LRP5 LRP6 PTEN MTOR IRS1 CTNNB1 PMC9322890__F11 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) MAP3K7IP1 NLRP3 KEAP1 TLR9 IRAK1 TRAF6 IRAK4 IL1B MYD88 PMC9322890__F10 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) FOXA1 BAX EGF MTOR PMC9658772__F2 E3 Ligases in Cervical Cancer and Endometrial Cancer EGFR RBBP6 SMAD2 SMAD4 PTEN SKP2 CTNNB1 MKRN1 RNF43 NOD2 FHL1 MDM2 TRIM65 PMC6728366__F7 The PCP and Wnt pathways act in parallel to establish coordinated hair cell polarity and orientation in the neuromast GPC4 PMC9503233__F1 Gut Non-Bacterial Microbiota: Emerging Link to Irritable Bowel Syndrome SYK RAF1 NLRP3 TLR4 IRF3 CARD9 MYD88 PMC4992866__F11 Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation RPS6 EIF5A PSAP PMC3499531__F6 Transcriptome Sequencing and Annotation for the Jamaican Fruit Bat (Artibeus jamaicensis) CST2 MAP2 ING1 RAC3 MAPK3 PMC10382028__F1 Plant-derived extracts and metabolic modulation in leukemia: a promising approach to overcome treatment resistance CXCL12 JUN PCNA PFKP HEL-S-162eP MTOR HEL-S-87p HEL-S-30 CXCR4 PMC3470040__F1 MYCN-dependent apoptosis and the MDM2–p53 pathway BMI1 HMGA1 HIPK2 MDM2 PMC6040253__F1 Schematic model of the regulation of the Nrf2 signaling pathway RBX1 KEAP1 NQO1 MAF PMC3034442__F3 Glycine synthesis and degradation GLDC GCSH AMT DLD PMC2677061__F1 Postnatal Roles of GDNF Family Members in Nociceptors Plasticity NGF GDNF GFRA3 RET PMC6947889__F7 Induction of pyroptosis via ER stress and the effects of SIRT1 on this process ATF4 EIF2A SIRT1 PMC5979320__F2 BCAAs balance and its multiple roles via PI3K-AKT-mTOR signaling pathway RHEB RICTOR TTI1 MTOR DEPTOR IRS1 PMC11849169__F1 Pathway for triterpenoid saponin biosynthesis in S IPP PDC PMC11876490__F3 Enrichment by Gene Ontology (GO) and pathway terms were visualized using the ClueGO/CluePedia plugin from Cytoscape RTCB RAN ESRP1 GARS1 TJP1 RCC2 INF2 SH3GL1 YIPF6 ARF5 COPS6 TARDBP LIMS1 H2AC19 COPZ1 HIST1H2AH TRNT1 PSPC1 ATP6V0D1 TRAPPC5 TUBB H3-7 IARS SNX27 UBA3 VPS35 PAFAH1B1 NARS1 AP3B1 SND1 GNA13 RAB10 H2AC20 GFPT1 RAB22A RAB5B IGF2R NAPG PEAK1 CSTF2 COPS4 TLN1 EEF1A1 NCBP2 SRSF9 PAPSS1 ACTG1 H2AC14 EEF1E1 HIST1H2AK H2AJ EEF1G EIF5 PPP2R1A ARL8B USP9X HDAC1 HEL-S-130P PPP2R2A PPA2 PS1TP5BP1 PMC11849169__F5 Construction of a biosynthetic pathway for CK production in S IPP ENO1 ERG PMC4530213__F5 Functional connections brought by the active clusters between T2D and obesity SOCS1 PRLR CSF2RA PIK3R3 EGFR JAK3 PRKCZ SMAD4 NTRK3 MAPK3 INSR EPOR PRKCA CHUK HEL-S-1 JUN FRS2 CRKL LEPR PTPN11 IL6 FOS CNTFR CBL TCF7L2 GRB2 UBE2I TYK2 PMC8385664__F2 microRNAs, the Link Between Dengue Virus and the Host Genome GSK3B IRF3 TLR7 MYD88 PMC11876490__F4 Enrichment by Gene Ontology (GO) and pathway terms were visualized using the ClueGO/CluePedia plugin from Cytoscape ATP2B1 HINT1 PCNA SORD USO1 GSK3B LYZ H2BC11 PEX5 SPTBN1 ATP6V0D1 RUNX2 DNPH1 RBX1 FTL TUBB2A HEL-S-162eP PSMB10 AGA PMC7544989__F10 Ouabain effects in cultured human skeletal muscle cells STAT3 ATP1A1 SRC PMC4344548__F1 Sites of canonical Wnt signaling deregulation in PD LRRK2 APC GSK3B LRP5 LRP6 WNT3 PMC9598597__F3 Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties TLR4 CD14 TRAF6 MYD88 PMC12066262__F1 Pancreatic intestinal lung pathway in acute pancreatitis IL10 IL6 TNF PMC7053872__F5 Potential pathway of NAFLD development LPO CYP4A11 IL1B PMC5797541__F1 Representation of proteins and protein complexes involved in the “Autophagy – animal” KEGG pathway TSC2 ATG3 TSC1 HEL-S-130P HEL-S-69p CTSL PIR PTEN HIF1A PMC8990928__F1 Genotype-Guided Prescription of Azathioprine Reduces the Incidence of Adverse Drug Reactions in TPMT Intermediate Metabolizers to a Similar Incidence as Normal Metabolizers NUDT15 XDH TPMT PMC2604897__F2 Putative biochemical pathways involving MGAT3 TCF12 UNK CP PMC9698579__F3 Can Natural Products Targeting EMT Serve as the Future Anticancer Therapeutics? CDH2 TIMP3 PMC3109034__F6 Working model for the role of the miR-29 family in TGFB2–mediated signaling PMC6321710__F9 Pathway visualization CBL INSR FOXO1 INS PMC5123939__F1 Two-signal model for NLRP3 inflammasome activation CASR GPRC6A MAVS NLRP3 NOD2 IRAK1 NOD1 IL1B FADD BRCC3 PMC5123939__F2 Activation for non-canonical and alternative NLRP3 inflammasomes NLRP3 TLR4 RIPK1 FADD MYD88 PMC9428607__F2 Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression? DRD1 DRD2 GSK3A DRD4 DRD5 GSK3B DRD3 PMC3949576__F2 Effective double whammy targets DNA synthesis in leukemia TK1 NDP PMC7457014__F5 Knockdown of DAP alters gene expression of the mTOR signaling pathway during proliferation of turkey satellite cells RHEB RPS6 TSC2 EIF4B TSC1 ULK1 RHO MTOR ELF3 EIF4E PMC1782267__F2 TGF–TAK1 pathway SMAD2 SMAD4 ATF2 PMC1782267__F1 TGFB1–Smad pathway SMAD2 SMAD6 SMAD4 PMC8317223__F2 Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids in Uncaria Hook CYP2C19 CYP3A4 PMC7581990__F1 Metabolic reprogramming is involved in malignant transformation of prostatic cells ACLY HEL163 FASN ACD PMC5832558__F1 Urinary excretion of citric acid (TCA) cycle metabolites and the renal expression of genes that regulate these metabolites were significantly reduced among participants with versus without non-diabetic CKD HEL60 FH ACO2 IDH3B CS SDHD SDHA SDHB SUCLG1 SUCLA2 OGDH SUCLG2 HEL-S-32 OGDHL HEL-S-26 SDHC PMC8645640__F7 Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Carcinoma by Inhibiting IL-6 Signaling Pathway STAT3 IL6 PMC4089598__F2 Regulatory T cells and co-stimulatory pathways APC CTLA4 PMC7923240__F8 De Novo Transcriptome Assembly of Two Microsorum Fern Species Identifies Enzymes Required for Two Upstream Pathways of Phytoecdysteroids IPP EBP DHCR24 MVD DHCR7 MVK PMC9117991__F5 Lactate and the Lactate Dehydrogenase in Inflammatory Diseases and Major Risk Factors in COVID-19 Patients CD44 HEL-S-133P PMC5240418__F1 The notch signalling pathway in prostate cancer NOTCH1 PMC8762210__F11 High Ratio of the Plasma miR-96/miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer MAPK1 RPTOR PIK3CA SGK1 ATP6V1G3 ATP6V1A PTEN IGF1R MTOR ARHA KRAS WNT10A IRS1 ATP6V1G2 RHEB ATP6V1E2 RICTOR ATP6V1C1 ATP6V1C2 PDPK1 ATP6V1E1 GRB2 PMC8762210__F10 High Ratio of the Plasma miR-96/miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer CASP9 COMP GNB3 GNG10 PDGFA AKT3 JAK3 GSK3B GNG12 NTRK2 PTEN PPP2R5C ENG ANGPT1 PPP2R2B CHRM2 PDGFRA FGFR4 RS1 MX2 CREB1 PMC6352191__F7 Proposed regulatory network involved in Keratinocytes of Type 2 Diabetes TH BTK PRL TLR9 MX2 MX1 TLR7 OAS3 ISG15 OAS2 CP PMC5926825__F1 Reactive Oxygen Species in Metabolic and Inflammatory Signaling TSC2 STIM1 ATM HIF1A MTOR PMC6352191__F6 Protein–protein interaction (PPI) network in cluster 1 from the MCODE sub-network analysis MAVS PLSCR1 EGFR DHX58 STAT1 PARP12 IFI44 USP18 NOD2 EPSTI1 MX2 APP MX1 ATN1 ISG15 SRC OAS2 EIF2AK2 UBC IRF9 IFITM1 IRF1 SP110 POLR2F OAS3 XAF1 SAMD9 ATG12 ELAVL1 OGDH HERC6 BIRC2 BCL6 PMC7857696__F1 Natural and synthetic mucin-type O-glycosylation pathways HEL-S-62p C2 C1GALT1 ST6GALNAC1 PMC7338805__F7 Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress MAF NRF1 PMC9138239__F1 Key Molecules of Fatty Acid Metabolism in Gastric Cancer ACLY DEK BOLL FAS FASN GSK3B MTOR CEBPB CTNNB1 CD34 PMC11591473__F6 Oxidative stress induced senescence pathway SUZ12 JUN EED MAPKAPK2 MAPKAPK3 EZH2 MINK1 KDM6B TXN MAP2K4 MAP2K6 IFNB1 MDM2 MAP2K3 PMC7381543__F2 Molecular and metabolic regulation of effector and memory T cell differentiation P2RX7 CD40 STAT3 TET2 CXCR3 CD80 ID2 CD27 TNLG8A IL27 APC SOCS3 STAT1 KLRG1 STAT4 LEF1 BCL6 PMC11095605__F2 Activation and inhibition of the Wnt/Beta-catenin signaling pathway SFRP5 TMEM88 CTNNB1 PMC5124731__F1 Production of aromatic compounds via shikimate pathway in microbes PDC SMO PPY PMC11591473__F4 Detoxification of reactive oxygen species pathway GPX2 CCS TXN2 NOX4 HEL-75 HEL-S-44 PMC9166526__F5 Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape ZMYND8 CD24 AXL HIF1A SRC CTNNB1 PMC8165473__F2 Anti-inflammatory and Proangiogenic Properties of High-Density Lipoproteins: An Emerging Role in Diabetic Wound Healing CXCL1 VCAM1 CCL2 TNF PMC9501315__F2 Cardio-Oncology: Mechanisms, Drug Combinations, and Reverse Cardio-Oncology VWF KEAP1 BCL2 MTOR PMC11015399__F1 Hippo signalling pathway and its impact on eye diseases RHO NF2 PMC5994134__F4 Reconstruction of metabolic pathway of Woesearchaeota in the central carbon (a) and comparison of genes relating to the ferredoxin-dependent pathways between organisms from oxic and anoxic biotopes (b) NAPA CPA2 COPA PMC10529747__F3 TGFB as A Master Regulator of Aging-Associated Tissue Fibrosis SMAD2 SMAD4 ATM NOX4 PMC6168472__F7 Proposed mechanistic model of KMT2D in prostate cancer KLF4 OSM PDPK1 MLL2 LIF PMC2854285__F2A mTOR and cancer: many loops in one pathway TSC2 TSC1 DEPTOR PMC4578605__F3 Depletion of Pkh affects glycogen metabolism PGM3 PGM2 PMC12154116__F10 KEGG pathway maps enriched with downregulated differentially expressed genes (DEGs) in THP-1 cells following treatment with Biochanin A (100 μM) STAG2 TRIP13 TICRR CDC14B MAU2 PCNA STAG1 ESCO1 SMC3 SMAD4 CYC1 CDT1 MYT1 SKP2 RAD21 KNL1 MTBP CDK7 DDX11 CDC45 CDK2 WAPAL MDM2 NIPBL PMC2861828__F1 Signaling pathway that connects store-operated Ca2+ entry with NFAT-dependent gene transcription in T cells ORAI1 LAT MCU ITK HEL-S-11 PMC8277837__F5 Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma MLYCD KLF4 SMAD1 SLC39A14 DKFZp781O1323 TUBB4B SMAD2 SLC7A11 SETDB1 TUBA1B TUBB6 KMT2A ZNF331 INSR MLL2 CTGF ZNF460 ZFHX3 TUBA1A TLR5 TUBA1C ID3 ACACB NR3C2 ZNF550 ZNF607 TCF7L2 ANGPTL4 ZNF627 ZNF569 ZNF324 ZNF565 ZNF763 ZNF443 ZIK1 EP300 ZNF461 ZNF37A ZNF614 ZNF354B PMC11876390__F1 Metabolic pathways of polyamines ASL SMS SRM OTC EIF5A PAOX DOHH DAO ARG2 DHPS PMC2984459__F1 Schematic overview of Toll-like receptor (TLR)4 signaling pathway STAT1 TLR4 CD14 TRAF6 LBP MYD88 PMC6417856__F10 The main findings are illustrated (A) CACNB1 RYR1 ChAT SNAP25 CHRNA1 PMC6481626__F1 Pathways that influence uracil accumulation in DNA TK1 UNG TYMS PMC4231421__F7 LPA-dependent platelet-induced tumor cell metastasis LPA EGF PC PMC6501144__F2 Angiogenesis signaling pathways induced by oxidative stress TLR3 ATM TRAF6 MYD88 PMC3016978__F6 Model for a meiotic gene regulatory cascade initiated by inactivation of a pathway that promotes turnover of meiotic transcripts produced in vegetatively growing cells TRO REC8 FBP1 MEI4 PMC9690211__F6 Transcriptome Analysis of Chinese Cabbage Provides Insights into the Basis of Understanding the Lignin Affected by Low Temperature HEL114 CAD PMC5762868__F1 Schematic diagram of the metabolic cycle of THF and the C1 metabolic pathway MTHFD2 MTHFD1 AMT MTHFD1L HEL-S-51e PMC7163125__F10 LXA4, a potential therapeutic agent against KSHV SGK1 AHR MTOR PMC7226428__F1 Growth hormone (GH) on the vascular endothelium GHB2 GRB2 SHE SRC GHR PMC3414427__F3 Schematic model showing the existence of distinct secretory pathways in pheochromocytoma TH PNMT DBH NPY CADPS SNAP25 PMC4613136__F2 CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division ERCC1 XPA RAD51D ATR MPG PMS2 BRCA2 OGG1 RAD17 RAD9A UNG ATM PARP2 SMUG1 TDG MGMT HUS1 RAD52 RAD51 MSH2 MSH3 H2AX SSB XPC TP53BP1 PARP1 XRCC3 PMS1 RAD51B XRCC5 MLH3 RAD51C LIG1 RAD1 BRCA1 APEX1 TREX1 RAD9B PMC4613136__F1 CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division ERCC1 XPA RAD51D ATR MPG PMS2 BRCA2 OGG1 RAD17 RAD9A UNG ATM ND2 PARP2 SMUG1 TDG MGMT HUS1 RAD52 RAD51 MSH2 MSH3 H2AX SSB XPC TP53BP1 PARP1 XRCC3 PMS1 XRCC5 MLH3 RAD51C LIG1 RAD1 BRCA1 PRKDC TREX1 RAD9B PMC3131053__F1 Differential involvement of IKKB/NFKB signaling in neurons of the hypothalamic arcuate nucleus in the pathogenesis of obesity and hypertension POMC NPY AgRP PMC4594510__F4 Schematic diagram for the signaling pathway involved in dexamethasone-induced TRPC4 channel activity RASD1 TRPC4 NACA2 PMC8221613__F1 General schematic of astrocyte reprogramming using TFs and miRNAs ASCL1 SOX2 PMC7641965__F3 Integrating immunotherapy and targeted therapy in cancer treatment: mechanistic insights and clinical implications STAT3 EGFR PTEN CCL5 CXCL10 MYC KRAS CD47 CXCL3 CTNNB1 CCL7 CCL4 IL8RB CCL1 PMC7641965__F1 Integrating immunotherapy and targeted therapy in cancer treatment: mechanistic insights and clinical implications CD80 APC ARG1 LAG3 PMC5888911__F7 Schematic representation of the influence of high NT on FA anabolism and catabolism biosynthetic pathways LPA PC PMC8740421__F7 Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation AGO2 TLR4 NRP1 PMC3744802__F5 Model of regulation of the length of D-loop extension by PCNA and choice of polymerase PCNA POLK POLN PMC11048329__F3 Schematic presentation of current evidence on Cx32 association with signaling pathways regulating proliferative and cell death processes RIPK3 HDAC1 MLKL EGFR RIPK1 MTOR SRC TNF CCND1 PMC11048329__F2 Schematic presentation of current evidence on Cx32 association with EMT and the HCC chemotherapeutic resistance with oxaliplatin or doxorubicin CTNNB1 PMC3594782__F1 Serotonergic transcriptional networks and potential importance to mental health SPR TPH2 PMC7609422__F1 Core proteins involved in the autophagy pathway and its regulation in zebrafish, knockout (KO) zebrafish lines highlighted in red, and boxes show commonly used drugs which can activate (green) or inhibit (red) autophagy activity DRAM1 ATG101 LAMP2 ATG3 ATG12 SPNS1 ULK1 AMBRA1 KIAA1632 MTOR OPTN ATG5 PMC2196031__F8 Schematic presentation of the proposed sites of inhibition of the ceramide pathway by CrmA and Bcl-2 FAS FADD PMC6607964__F6 Snapshot of trastuzumab resistance pathway ERBB2 LDHB PMC3030666__F2 Impact of Aging on Dendritic Cell Functions in humans IRF3 PTEN IL6 MYD88 PMC4682110__F5 Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas CDC42 FSCN2 STK11 ITGB4 EGFR SMAD2 BRAF SFN SMAD4 CDKN2B MTOR SETD2 MYC RAC3 CDKN2A CDK6 ALK IQGAP3 ITGB8 CHEK2 FLT1 MDM2 SRC CCND1 SMARCA4 CDK4 RHPN2 TRIO KDM5B APC RAC1 CCNE2 TSC1 ERBB2 CREBBP LRP1B MAP2K1 PMC11528492__F5 Bioinformatic reconstruction of the L HPD TRO PAH CS PMC7901941__F1 Characterizing oligodendrocytes throughout the lineage MOG MBP PDGFRA SOX10 OLIG1 PMC3715049__F1 Proteomic strategies for studying the mechanism of miRNA processing and miRNA-mediated translation repression SRM DROSHA SCX PMC5937267__F1 Finally, expression of T-cell co-stimulatory and co-inhibitory receptors can be modulated by hypoxia as well CCL28 FOXP3 PMC4026680__F1 Early life stress can influence development of the HPA axis, as well as regulation of satiety-related hormones, leptin, insulin, and ghrelin to alter feeding behavior long-term CRH ARC AVP PMC4391824__F3 Expression of the known genes involved in polo signaling in PAH HPASMC APC PRC1 SMC3 POLE SLK PMC3807757__F1 MyD-88 dependent TLR signaling pathway: MyD-88 (*) associates with the cytoplasmic domain of TLR, recruiting IRAK1 and IRAK4 to activate TRAF6 TLR1 TIRAP TLR4 TLR9 IRAK1 TLR7 TRAF6 IRAK4 MYD88 PMC11379068__F8 The interaction between the PERK/ATF4 branch of endoplasmic reticulum stress response and mitochondrial one-carbon metabolism after ICH MTHFD2 ATF4 HEL-S-51e PMC11549785__F1 LncRNAs modulate MR of solid tumor cells by targeting glucose metabolism PGAM1 ATG12 HEL-S-133P HEL-S-68p ENO1 IGF2BP2 MTOR ATG5 PMC4768675__F9 RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity MAVS ATG12 DHX58 ATG5 CYLD UNK PMC10537991__F4 Quantitative Differences in Rumen Epithelium Proteins in Lambs Fed Wheat, Perennial Wheat, or Perennial Wheat plus Lucerne MCAT MECR OXSM HTD2 ACSF3 CBR4 IDH3B ACADSB ACADS HACD2 PMC6305318__F2 Summary of the interactions between SIRT1 and the canonical Wnt pathway HMGB1 APC GSK3B RUNX2 SIRT1 CTNNB1 PMC4768675__F6 RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity RBPJL EP300 ADA PMC3714282__F1 Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway TH MPG PMC11549785__F4 LncRNAs orchestrate MR in solid tumor cells by influencing interactions between tumor and non-tumor cells in TME HEL-S-133P PFKFB2 CXCL14 PMC7074507__F1 TCR/CD3 complex and CD28 downstream signaling pathways leading to activation of transcription of genes for cytokines, chemokines, cell division, activation of effector function, and survival CDC42 CTLA4 MTOR PMC4768675__F7 RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity RIPK2 NLRP3 TRIP6 PMC3522553__F1 Components of the Hedgehog (Hh) Signaling Pathway and molecular sites targeted by Hh pathway inhibitors SUFU SHH SMO PMC11549785__F2 LncRNAs modulate MR of solid tumor cells by influencing lipid metabolism ACSL1 NR1C1 FABP5 CD36 NPM1 FABP4 HNRNPC CPT1A PMC9010455__F2 Upstream Regulator Analysis, based on “omics” integration using the Ingenuity Pathway Analysis software STAT3 CD81 JUN AXL EGFR TAP1 ATF2 MTOR CD44 C2 CRABP2 RELA NPM1 NFKBIA MMP2 DKFZp686P11128 ISG15 HNRNPK TNFSF10 SMARCA4 PMC7841890__F4 Activation of the antioxidant signalling pathway by natural remedies against polyQ-induced SCA HEL-S-22 GCLC CYCS PMC8235637__F3 Molecular and Functional Analysis of Sunitinib-Resistance Induction in Human Renal Cell Carcinoma Cells FLT3 CD36 KIT LPAR1 MTOR ARHA CTNNB1 LAMP2 LPAR4 LPAR2 HDAC7 RET LPAR3 PMC3132554__F2 Small-molecule inhibitors of the PI3K signaling network RHEB CASP9 TSC2 BAD TSC1 PTEN MDM2 PMC7484123__F1 Metabolism of hydrogen sulfide CTH ETHE1 SQOR SUOX PMC5546429__F8 Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice CDK5 MTOR BDNF PMC11084413__F5 KEGG pathway analysis of carnosic acid downregulated proteins associated with glycolysis/gluconeogenesis HEL-S-133P ALDH3A1 HK2 HEL-S-162eP PFKL PMC8948419__F5 Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans PMC9294245__F4 Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells BAX MCL1 BCL2 MDM2 PMC9294245__F2 Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells SMO RSPO3 PMC6843238__F2 ALDH1A1-retinoic acid-HIF-1Alpha-VEGF pathway is activated in breast cancer MCF-7 cells (A) TET2 CXCL12 HEL-S-53e RARB RXRA SOX2 ERBB2 SRC MYC CXCR4 PMC4889241__F4 p27 in cell-cycle regulation MCM7 E2F4 RHO GRB2 PMC12246546__F8 Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors ARHA B3GNT3 PMC5691642__F2 Suppression of type I IFN production by Flaviviridae viruses TBK1 STAT1 MAVS STAT2 IFNAR2 IRF9 IRF3 IRF7 TYK2 PMC12246546__F5 Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors ECT2 RHOB ATM ARHA CCND1 PMC6784043__F1 Novel insights into the dectin-1 signaling pathway TRIM62 NOS2 SYK RAF1 BCL10 PLCG2 CARD9 PMC2896660__F2 Placing datasets into a functional context using pathway analysis RPS24 APP MB PMC5822656__F1 MiRNA biogenesis, function in cytoplasm and nucleus-cytoplasm transport DCP2 DGCR8 AGO2 DROSHA PMC6089847__F2 Pathways of T-cell inactivation and mechanisms of monoclonal antibodies HAVCR2 CD80 TIGIT CTLA4 PMC7660678__F1 Pathway for the endogenous synthesis of arginine NAGS ARG1 ARG2 CP PMC5541427__F5 Effect of selecting different subsets of CpG sites in the “TNF signaling pathway” BAGE JUN ITCH CLPS AGA PMC6784043__F2 Crosstalk between different PRRs in antifungal immunity SYK NLRP3 IRF1 MDM2 UNK IL1B CARD9 MYD88 PMC5541427__F1 Snapshot of PiiL in group-wise view mode, showing the “cell cycle” pathway CDC20 PCNA TFDP1 SP2 ATM MYC PLK1 TNF PMC6991658__F9 Mechanism diagram CDH2 CDK2 ATM PMC5921923__F1 Using gene expression data to direct breast cancer therapy: Evidence from a pre-clinical trial STAT3 EGFR ARHA SRC MYC PMC5541427__F2 “cytokine-cytokine receptor interaction” subsection of the “pathways in cancer” pathway, with (a) DNA methylation data, and (b) gene expression data FLT3 STAT3 EGF TGFA HGF RASSF1 EGFR FLT3LG STK4 MYC CXCL8 PLCG1 CRB2 RALA FGFR1 PRKCA CCND1 RALBP1 CDK4 JUN TFG KIT ARHA FOS KITLG ARAF HRAS IGF1 PDGFRA JAK1 MAP2K1 GRB2 RET PMC7781009__F1 MET oncogenic activation STARD3NL TPR CBL HGF ST7 HLA-DRB1 PMC9047906__F5 Serglycin Is Involved in TGFB Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue SRGN CD44 TGFB1 SMAD2 SMAD4 CREB1 PMC3887911__F4 CRAC channel regulation by multiple Ca2+-sensing molecules in the ER and cytoplasm ORAI1 STIM1 CRACR2A PMC3887911__F3 Interacting partners and posttranslational modification of Orai1 and STIM1 CDC2 ORAI1 STIM1 CRACR2A PMC3887911__F2 Activation mechanism of Orai1 and STIM1 CDC42 ZAP70 ORAI1 LAT STIM1 VAV1 RAC1 PMC9207250__F2 Vitamin D: A Potential Star for Treating Chronic Pancreatitis NR1i1 CDC2 CYP2R1 CYP27B1 CYP24A1 CYP11A1 AHR PTH CYP3A4 CYP27A1 PMC6390244__F4 Target-pathway network analyses results GRIA2 ADRA1A ADRA1D CHRM3 PTGS2 TNF SCN5A SLC6A2 ADRA1B GABRA2 SLC6A3 CHRM2 ADRA2A OMP ADRA2C ADRB2 PKIA ADRB1 MB PMC8866335__F2 Small, Dense Low-Density Lipoprotein-Cholesterol and Atherosclerosis: Relationship and Therapeutic Strategies BAX ATF3 CYP8B1 TRPC1 LDLR ARHA RHO TRPC3 PMC2645860__F2 Pathogenetic mechanisms of CCAAT enhancer binding protein alpha (C/EBPA) dysfunction TRIB2 CBFB BCR EBP NOTCH1 PMC5015973__F8 Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming STRA8 SMAD4 NODAL NANOS2 PMC1779900__F6 Some signaling pathways that could mediate long-term changes in cellular plasticity as a function of sexual experience CDK5 ARC GRB2 SHE FOS PMC8620571__F1 An Atypical Case of Congenital Erythropoietic Porphyria HMBS CPOX ALAS1 ALAS2 FECH UROD UROS PMC4761092__F10 Scheme of the role of (+)‐naltrexone and (+)‐naloxone in TLR4 signalling IL16 TLR4 IRF3 MYD88 PMC4864395__F5 Menadione Suppresses Benzo(A)pyrene-Induced Activation of Cytochromes P450 1A: Insights into a Possible Molecular Mechanism AHR CYP1A1 PMC12069246__F3 P38 MAPK signaling pathway is regulated by ubiquitination in MASLD TRIM16 TRIM38 MAP3K7IP1 TNFAIP3 USP4 TAB3 USP18 TRAF5 FBXW5 TRAF3 TRAF6 CYLD PMC3663533__F8 The regulation of TLR signaling by Lgr4 TIRAP TLR4 LRP5 CD14 LRP6 TRAF6 CTNNB1 MYD88 PMC8998228__F1 Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family BAX BAD BOK BMF HRK BIK PMC10520882__F7 Biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype CAMKK2 MTOR CAMKK1 PMC7343490__F2 Network analysis including the 125 differentially expressed proteins at 24 h after SARS-CoV-2 in Caco-2 cells LTBP1 AURKA UBE2C STAG1 HEL111 SDC4 VTN AFP F10 USP16 CIT SP1 LAMC2 MORF4L2 KRT14 APOE POLR2F ARHA GPC3 RANBP2 APOA2 SPC25 CEBPA NEDD4 AURKB DCAF13 PSAP PMC3632385__F2 Schematic overview of estradiol-mediated genomic signaling pathway via ERA/B and rapid nongenomic signaling pathways via GPER, Gq-mER, and membrane subpopulation mERA/B EGF EGFR SRC PMC4522276__F1 Molecular Insight into Dengue Virus Pathogenesis and its Implications for Disease Control STAT1 CGAS STAT2 PMC7503882__F2 Molecular pathogenic signaling pathways in ACM LATS1 LATS2 SMAD2 GSK3B LRP5 SMAD4 LRP6 NF2 CTNNB1 PMC5037500__F2 A glutamatergic synapse and the molecular circadian clockwork GFAP NACA PMC5346417__F5 Diagram showing the hypothetical model for regulation of NCC phosphorylation in the DCT cell, and hence the level of transcellular NaCl flux KCNJ10 WNK4 DCT PMC4350352__F6 TAp73 promotes anabolism TP73 VAMP2 SLC17A7 PMC5548957__F2 Rotavirus interactions with the host innate system: viral entry into cells and viral double strand RNA (dsRNA) induce the generation of pathogen-associated molecular pathways (PAMPs) TBK1 RIGI TLR3 IRF9 IRF3 IRF7 TLR7 PMC7911620__F1 TLR-activating adjuvants and the induced signalling pathway MPL CD80 TLR1 TLR3 TLR4 TLR9 TLR8 TLR5 TLR7 CCL2 IL1B MYD88 PMC6409969__F7 Cell Cycle Arrest and Cytotoxic Effects of SAHA and RG7388 Mediated through p21WAF1/CIP1 and p27KIP1 in Cancer Cells CDC2 BAX AURKB MDM2 PMC11808623__F5 Mechanism of CSEAE regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway (Created with BioRender APOE MVD PMC2886300__F2 Role of ROS in TNFA induced endothelial dysfunction TRAF4 SKI PMC4462130__F6 a, Gene interaction map of Reactome pathway analysis that discovers alteration of FGFR signaling as the most altered pathway PIK3CA RAF1 PXN PIK3CD FGF7B PTEN PHLPP1 FGFR4 FGFR1 CAMK4 ADCY6 MDM2 FGF23 FRS2 ERBB4 KRAS IRS1 HRAS NRG1 RICTOR GSK3A FOXO1 PDGFRA CSK ERBB2 ARHGEF7 CDC37 PMC3998024__F2 Top-ranked gene network RNASE3 LTA IFNA13 CD27 SERPINA1 TRAFD1 TRAF3 TSLP WDFY3 BCR ARF4 CCL4 INPPL1 FCAMR AKAP12 ATG5 PMC5799271__F2 TLR4 signaling pathways TBK1 TLR4 IRAK1 IRF3 TRAF6 IRAK4 MYD88 PMC10938783__F7 Multifaceted mechanism of KTC1101 in anti-tumor therapy and immunomodulation IFNG CCL5 MTOR CXCL10 PMC2874340__F1 Folate cycle, methionine cycle, and transsulfuration pathway HEL-S-61p PMC8507309__F5 RNA-Seq reveals different responses to drought in Neotropical trees from savannas and seasonally dry forests ATG101 ATG10 EBF2 ATG3 ATG12 ATG5 PMC5729411__F7 Summary of the main findings EED TLR3 APC MMP9 CTNNB1 PMC8228919__F1 Toll-Like Receptor Signaling in the Establishment and Function of the Immune System TBK1 TLR9 IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 UNC93B1 TLR1 TLR3 TLR4 TLR8 TLR7 PMC6891142__F4 The suppressive effects of Crabp1 in adipogenesis and adipocyte hypertrophy CEBPA IGF1 CRABP1 IGF1R CEBPB IRS1 CTNNB1 PMC10857877__F6 RND3 induction and interaction with TLR4 and IFNG receptor signaling in activated proinflammatory macrophages CXCL10 NOTCH1 PMC7487489__F7 MAPK signaling pathway MAX ECSIT FAS RAF1 TRADD CD14 ATF2 TNF FLNA NLK GCK GRB2 TRAF2 PMC4768065__F7 Proposed model of the involvement of Spry2 and Spry2 siRNA in TLR, IFNG receptor, and growth factor signaling pathways for suppression of M1 polarization and enhancement of M2 polarization in macrophages SPRY2 IFNG EGF ARG1 MYD88 PMC7226927__F5 Action of Hedgehog signaling pathway SMO GLI3 PMC7985092__F1 Schematic diagram of the insulin-like growth factor (IGF) signal transduction and main downstream effects BAD PTEN IGF1R INS SHE IGF2 DEPTOR IRS1 RHEB IGF2R TSC2 TSC1 IGF1 INSR MDM2 GRB2 PMC8904960__F1 Non-Canonical Roles of Apoptotic Caspases in the Nervous System BAX FAS APAF1 PMC4666504__F7 Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake EGF NRG1 ERBB4 EGFR PMC6341984__F1 Tuberculosis and impaired IL-23-dependent IFNG immunity in humans homozygous for a common TYK2 missense variant STAT3 STAT1 STAT2 IFNAR1 STAT4 JAK1 IL23R TYK2 IL12RB1 PMC7337897__F6 MDM2 regulates E2F1 synthesis during EBNA1 mRNA-induced translation stress CDC2 CDK2 MDM2 CDK4 PMC9565759__F4 Possible Synergies of Nanomaterial-Assisted Tissue Regeneration in Plasma Medicine: Mechanisms and Safety Concerns STAT3 CCS PRC1 HEL-S-44 PMC7985092__F2 Several proteins in the IGF signaling pathway such as IGF1, IGF2, IGF-1R, and IGFBPs are regulated by miRNAs BAD IGF1 INSR IGFBP1 IRS4 GRB2 MTOR RUNX2 IGF2 ELF3 IRS1 PMC8275668__F6 Application across species of a one health approach to liquid sample handling for respiratory based -omics analysis CDH2 SFTPA1 HRG CMPK1 C1QB SFTPD B2M AFM HEL-S-99n TXN MUC5AC CFP ARF3 C1QC ARF4 PMC4365929__F3 Ultraviolet B (UVB)-induced cell cycle signaling and the relationship between p53 and phospho-Chk1 (Ser317) CDC2 ATR CCNB1 PMC3092200__F9 Hypothetic scheme of cell death induction pathway triggered roscovitine and CR8 in human neuroblastoma (NB) cells CDK7 CDK9 CCNH PMC4881378__F1 Components of the TLR signaling network frequently mutated in lymphoid neoplasms MAP3K7IP1 TIRAP TAB3 TLR5 ATF2 TRAF3 MYC TRAF6 CYLD IRAK4 MYD88 PMC6696953__F2 ASD gene networks constructed with PASCAL associated genes and its FunCoup interactors HNRNPF ALYREF REN GNL3 SUMO2 NONO LYAR CALM1 ILF3 KCNN2 ADA PMC8592893__F4 Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer TIRAP GSK3B MTOR JAK1 MYD88 PMC10815665__F3 Proposed conceptual framework for the involvement of CXCR signaling in modulating Th1/Th17-driven pathologies IFNG CXCR6 CXCR1 IL8RB CXCR4 PMC3871617__F5 NHE Isoform Switching and KChIP2 Upregulation in Aging Porcine Atria CAV3 CAV2 BCR STOM APLN PMC10815665__F2 CXCR signaling pathway TF CXCL9 CXCL12 CXCR6 CXCL13 CXCL1 JAK3 CXCL16 CXCL2 CXCL6 CXCL10 CXCL8 CXCL11 CXCR5 PMC6962170__F4 Integrated metabolic, proteomic and transcriptomic functional analysis PRMT1 STAT3 HRH3 RARS2 MTAP CHAC1 SMOX ALAS1 TUBA1B AHCYL1 ASPA PMC12107871__F5 Proposal of the main molecular signaling pathways by which celecoxib exerts its anti-inflammatory action as a promising strategy in breast cancer therapy TH COX1 PMC5336563__F2 Regulatory networks of selected lncRNAs involved in the development of HBx-HCC CDK6 CCNE1 DBH CDK2 CCND1 CTNNB1 PMC4346366__F1 Consequences of tissue trauma on heme catabolism, reactive oxygen species, and polyunsaturated fatty acid metabolism.Notes: Top panel: following tissue trauma, release of free heme can serve as a signal for proinflammatory events LOX PTGIS FES PTGES PTGS2 HEL-75 PMC11758948__F9 Cell division regulation by the EphA2–Ephexin4–RhoG signaling pathway CDC2 ARHG EPHA2 PMC7141213__F2 Examples of mechanisms involved in the cellular response to low doses of phytochemicals–on the basis of findings presented in the current review KEAP1 FOXO3A SIRT1 PMC12107871__F3 Schematic description of the signaling process demonstrating the intricate cross-talk between NFKB and STAT3 in inflammation-induced cancer STAT3 BAX MMP2 BCL2 MMP9 TNF PMC12107871__F2 Graphical depiction of mechanisms responsible for inflammatory response mediating the onset of cancer via STAT3 signaling pathway STAT3 BIRC5 TGFA FZD2 EGFR CXCR4 CCND1 PMC12107871__F1 Inflammatory signaling mechanisms underlying cancer development mediated by the NF-kB signaling pathway EGF LTBR BCR EGFR RELB BCL2 CCL2 CXCR4 CXCL8 CCND1 PMC7408754__F2 Gas6/Axl signaling promotes the immunosuppressive tumor microenvironment CCL3 CCL4 CCL2 PMC8391332__F1 Microbiota-Gut-Brain Communication in the SARS-CoV-2 Infection CRP MTOR CXCL10 ACE2 PMC4324046__F2 Metabolic reprogramming in rheumatoid arthritis T cells FASN PMC4295378__F1 WNT signaling network CRP APC ARHA NLK CTNNB1 PMC3599859__F1 CySBGN overview COMP PMC4000313__F2 Death receptor signaling and programmed necrosis TRADD FADD PMC2991541__F3 Redox-control of Matrix Metalloproteinase-1: A critical link between free radicals, matrix remodeling and degenerative disease TNF UNK PMC8891514__F1 Pattern-Recognition Receptor Signaling by HBX During Hepatitis B Virus Infection ECSIT TBK1 MAVS AIM2 SP110 IRF3 IRF7 TRAF3 TRAF6 MYD88 NLRC4 MAP3K7IP1 NLRP3 TLR3 MVP TLR4 IL18 TRAF2 PMC9481235__F1 AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis TH AURKA TLR9 AIM2 CARD18 TLR7 PMC7037245__F2 IL-2R signaling and modulation of T cell activity SOCS1 EIF4B SHC1 STAT5B PRDM1 JAK3 IL2 GRB2 FOXP3 JAK1 GAB2 EIF4E PMC2581785__F1 Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum LIPC CAD PC FADS1 PMC11880738__F5 Dual role of copper in melanoma S100A4 CCS LOXL3 ULK1 BRAF ULK2 PMC2894618__F2 Lineage relationships of cells originating in the otocyst PROX1 HEY2 ATOH1 FGFR1 SOX2 SHH FGF20 FGFR3 FGF8 GLI3 PMC7936661__F3 Short loop commonality and a landscape of short loop commonality among proteins with mutations in the AML PPIN FLT3 FCGR2B SHC1 SOS1 KIT TNS4 MST1R PTPRG MPL CBL PKD1 INSR c-fgr BCR PTPRB PMC8262770__F1 Metabolic Control of Smoldering Neuroinflammation HK2 HIF1A MTOR TMEM119 PMC3631012__F1 Mi-2/NuRD complex making inroads into DNA-damage response pathway RFWD2 ATR PCNA H2AX INO80 MDM2 HDAC2 PMC8794704__F2 Inflammasome and Its Therapeutic Targeting in Rheumatoid Arthritis NLRC4 AIM2 TRIM11 IL1B PMC9582432__F2 Microglial autophagy in cerebrovascular diseases ULK1 MTOR PMC8363009__F6 Chemical-protein and protein-protein interaction network of cordycepin and unique proteins from DM+COR and shared protein from N+COR and DM+COR in livers on the hepatic metabolism pathway, analyzed by STITCH v 5.0 PSMB6 RFTN1 ACO2 PRKAG2 PSMB2 MTOR PRKAA1 NR1C1 FOXO1 OGDH PRKAA2 PRKAG1 PRKAB2 PRKAB1 MDH2 NFATC3 PMC6441168__F3 Functional network of cancer derived EVs in GC microenvironment HMGB1 TLR4 MSC PMC9352673__F5 Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies FUS STAT3 CD80 SOX9 CD36 ARG1 CD163 TNF IL1B MAPK6 PMC8447721__F1 Effective function of circular RNA in colorectal cancer ITCH CASP3 PMC11274312__F6 PPI network of the DEGs in immune-related pathways CD3D CXCR3 PDCD1 CD27 LAT CTLA4 TBX21 ICOS PRF1 PPBP ITK STAT4 CD3G CD8A CD3E LCK PMC5348722__F2 Translating genomic profiling to gastrointestinal cancer treatment ATR EGFR SMAD2 APC BRAF SMAD4 PTEN MTOR MYC KRAS IGF2 CTNNB1 FBXW7 NRAS ATM PMC7892431__F3 Dysregulation of nucleic acid-induced signaling during HCC development STAT1 EGF CGAS TLR3 AIM2 CXCL10 PMC7892431__F2 Viral manipulation of DNA-sensing and directly antiviral signaling pathways ADAR TBK1 CGAS TRIM56 MAVS TLR9 RNASEL AIM2 IRF3 IFI16 IRF7 MYD88 TRIM25 NLRP3 EIF2A IL1B PMC5348722__F1 Translating genomic profiling to gastrointestinal cancer treatment CCNE1 EGFR SMAD2 SMAD4 EZH2 PTEN MDM2 MTOR VEGFA CCND1 PMC4295378__F3 The WNT signaling network on cancer cell metabolism TSC2 TSC1 APC GSK3B CTNNB1 PMC7892431__F1 RNA sensing and viral manipulation of TLR and RLR signaling pathways TBK1 CASP8 MAVS NLRP3 IRF3 IRF7 MYD88 PMC5951828__F6 Potential role for AstC-R2 in nociceptor-bacterial-immune interactions in Drosophila TRPA1 HEL-S-11 PMC5069610__F2 NMI influences cancer initiation DRAM1 NMI GSK3B ATM MDM2 MYC PMC11575122__F9 CARMN mechanism involving transcriptional and post-transcriptional regulation SP1 MAPK13 KEAP1 TFAP2A YBX1 PMC4504941__F1 Molecular mechanisms of cardioprotection provoked by netrin-1 and netrin-1-derived small peptides DCC SIAH1 SIAH2 PMC5069610__F3 NMI inhibits cancer progression NMI TCF3 WNT3A DKK1 SMAD2 GSK3B SMAD4 TCF4 ZEB2 LEF1 CTNNB1 TGFBR1 PMC6606950__F4 Herbal medicines promote the activation of the HIF-1 pathway through different targets in ischemic stroke STAT3 MTOR PMC6606950__F3 Chinese herbal medicines inhibit the activation of the HIF-1 pathway in cancer treatment through different targets STAT3 PTEN MTOR TRAF6 PZP PMC7476086__F8 Proposed schematic model: CRISPR/Cas9-mediated knockout of SHP2 inhibits breast cancer proliferation by regulating Cyclin D1 stability via the PI3K/AKT/GSK3B signaling pathway GRB2 CCND1 PMC5394831__F3 GnRH signaling pathway containing PLCB1 and MAP2K6 CDC42 RAF1 MMP2 DAO PMC6072563__F1 Schematic represents various signaling pathways that occur within tumor cells, which allow for cell growth, proliferation, and invasion STAT3 CDK6 EGFR JAK1 CDK4 PMC2747760__F1 Leptin signaling: A key pathway in immune responses STAT3 STAT1 PTEN GRB2 IRS1 PMC3903477__F1 Characterization of Cyanobacterial Hydrocarbon Composition and Distribution of Biosynthetic Pathways ACP2 HEL-S-5 PMC4121847__F6 Diagram illustrating the proposed pathway by which TLR4/caspase-8/inflammasome up-regulation induces the processing of IL-1B and promotes the inflammatory response in acute glaucoma NLRP1 NLRP3 IL16 PMC7352588__F3 DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer UBC UBB PMC8101316__F1 Proposed Parkinson Disease Genetic Testing Pathway PINK1 LRRK2 PARK2 SNCA PMC7352588__F1 Hedgehog signaling pathway SUFU SMO GLI3 PMC9490146__F3 Targeting cellular senescence to combat cancer and ageing IFNG TBK1 CGAS IRF3 IL6 PMC6017243__F9 The above-mentioned findings PDK2 CCND1 PMC7352588__F4 E3-ubiquitin ligases and DUBs involved in Smo regulation DUSP8 HERC4 SMO PMC8262770__F2 Metabolic Control of Smoldering Neuroinflammation ACLY LPL TREM2 CIC TYROBP FABP5 CD36 CX3CR1 APOE MTOR TMEM119 PMC11880738__F1 Mechanisms responsible for copper uptake and homeostasis in cells ATOX1 CCS SCO1 SLC25A3 SCO2 ATP7B COX17 COX11 HEL-S-44 ATP7A PMC10189745__F1 IL-36 signaling pathway IL36A TRAF6 MYD88 PMC6521881__F2 Network of Neurotrophin signaling pathway HRAS CRK GSK3B MAP2K1 GRB2 BDNF IRS1 PMC8392047__F1 Selective Autophagy in Hyperglycemia-Induced Microvascular and Macrovascular Diseases ATG101 ATG10 TSC2 ATG3 TSC1 ATG12 ULK1 ATG14 ATF4 ATG5 PMC5557744__F11 Schematic summary of the interleukin-6 (IL-6)/STAT3 signaling pathway, highlighting its central role in regulating the expression of multiple genes and cellular functions in metastatic breast cancer cells STAT3 BAX CCND1 PMC4813224__F3 Argininosuccinate synthetase (ASS)-negative cell death induced by arginine deprivation BAX ASL MTOR PMC6500763__F1 Signaling cascades involving EGR1, PTEN, DMP1, ARF, and the p53 network EGR1 TGFB1 PTEN BBC3 MDM2 PMC8714937__F4 LKB1 Regulates Vascular Macrophage Functions in Atherosclerosis MTOR ABCA1 IL1B PMC6262272__F7A Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1 PIEZO1 LRP6 CTNNB1 PMC8255928__F5 Integrative Analysis of lncRNA-mRNA Profile Reveals Potential Predictors for SAPHO Syndrome TRIM13 FCAR ZNF793 NPIPB11 LOXL1 NPIPA3 SMIM14 MARCKS ANKRD28 SLC31A2 WDR73 MFSD11 ANKRD42 ADGRE2 ST3GAL1 ZNF316 ARHGAP26 HSF1 ARHGEF40 ACADVL MBD4 IKZF3 CLEC12A ZMAT3 EXOSC4 PLEKHH1 MBNL1 TIMM50 FCER1G OXSR1 EXPH5 PMC5668145__F5 Steady-state levels of TCA intermediates in control and KO livers and tumors and the expression of key enzymes in the glutaminolysis pathway CTRL HEL-S-162eP CS GLS2 PMC5606117__F4 Crosstalk between the genes (in blue) obtained from the systematic review of LR and their biological functions in the dopaminergic neurons UBC FYN DRD2 ABCC8 SNCA HTR2A SRC DDC PMC8533862__F8 Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses TBK1 STAT1 MAVS IRF9 IRF2 IRF1 IRF3 IRF7 JAK1 TYK2 IRAK4 MYD88 PMC3640510__F2 Diagram representing possible mechanisms linking HCV-induced oxidative stress with hepatocarcinogenesis NR1C1 NEIL1 DHCR24 MDM2 PMC3367861__F2 IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis EFNB2 EFNB1 JAK3 IL7R PMC2980759__F1 Examples of the inter-relationship between host, tumor, and environmental factors (pharmaco-epi-bio-genomic triad) that determine the response to tamoxifen in an individual patient (phenotype) SULT1A1 SRC CYP3A4 PMC11893596__F3 MLKL-related pathophysiological events in the endoplasmic reticulum and nucleus RIPK3 MLKL RIPK1 PMC11893596__F2 Pathophysiological actions of MLKL in the lysosome and endosome RIPK3 BAX HMGB1 MLKL CXCL1 CXCL2 MTOR PMC5216741__F6 MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis ASS1 HEL-S-107 PCNA IDH3B MTOR HEL-S-97n CRIP2 KRT19 PRDX3 AHR PAH HEL-S-15 ECHS1 NAMPT IL6 MAGOH PCK2 AGR2 DLAT NR2A1 HEL-S-130P UGDH CRABP2 HEL-S-49 PSAT1 PMC3367861__F1 IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis CDC42 FOXO1 PAK1 JAK3 JAK1 GABPA PMC5807041__F11 Top deregulated networks in NL-20 cells: Hematological system development and function, immunological disease, lymphoid tissue structure and development network induced by Caki-2 cells defined by Ingenuity Pathway Analysis PRDM5 MME BTRC FER TRIM69 NKX2-3 POLR2F TERF1 GHR ARHGAP32 ARHGAP24 PMC4997391__F4 Urinary Metabolomic Approach Provides New Insights into Distinct Metabolic Profiles of Glutamine and N-Carbamylglutamate Supplementation in Rats NAGS ASL PC PMC5807041__F12 Significantly deregulated networks in NL-20 cells: Cell-to-cell signaling and interaction, connective tissue disorder and developmental disorder induced by Caki-2 cells defined by Ingenuity Pathway Analysis GRM3 GPR37L1 HAUS8 WDR26 ARL10 LBX2 RHOU CIDEB HRBL FIBIN ZNF117 TFRC MUC6 CCBE1 GMPR PMC8542015__F3 Probiotics Interactions and the Modulation of Major Signalling Pathways in Host Model Organism Caenorhabditis elegans KRI1 CTNNB1 PMC6073630__F3 Disruption of ncRNA Networks in Cancer C6 POLL DIS3L2 AGO2 FOXO1 E2F3 POLI PTEN BCL6 PUM2 PMC5807041__F17 Deregulated networks in NL-20 cells: Cell-to-cell signaling and interaction, connective tissue disorder, developmental disorder networks induced by ACHN cells defined by Ingenuity Pathway Analysis KMT2A HCFC2 OGT GPSM1 AFF4 FOXK2 XAB2 SMPD1 PIGR MED1 RBPJ PMC2224366__F9 Innate immune modulation of CTL response to LCMV through MyD88 signaling PDC TLR9 TLR7 MYD88 PMC7499473__F1 Targeting CXCR4 CXCL12 MSC MTOR CXCR4 PMC9247256__F6 Alterations of Cardiac Protein Kinases in Cyclic Nucleotide-Dependent Signaling Pathways in Human Ischemic Heart Failure TF PYGM RPS10 RPS4X RPS3 RPS2 PFKP HEL-S-87p PFKM RPL30 PMC6759650__F5 Enrichment in multiple cancer-associated networks in breast cancer GREB1 ATAD2 KRT18 FOXA1 ZNF703 PKIB SHANK2 CITED1 CELSR2 SLC7A2 HMGN1 XBP1 UBE2T KRT19 FMN1 FKBP4 COBL TFF1 TTC9 GPAM TFAP2C CENPU RET PMC6759650__F4 Mechanistic network analysis predicts multiple affected signaling networks JUN SP1 EGFR MYBL2 IGFBP2 FOS CTNNB1 HDAC1 FOXM1 RARA CDKN1A FOXO1 NR3A2 SP3 TP63 TFAP2C EP300 PMC5489426__F2 Dual role of cellular prion protein in normal host and Alzheimer’s disease BAX FYN SRC PMC5779965__F5 Confirmation of some miRNA and target gene expression and integrative pathway analysis FBN1 SHE CDK4 PMC1785339__F4 Human and mouse mutations and the cognitive disorders affecting specific NRC/MASC signaling pathways and other postsynaptic proteins GRIA3 ERBB4 CASK PMC8229583__F7 17B Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway BAX GFAP LPO SYP PMC6315507__F2 Intermediary thiol metabolism in renal proximal tubular cells DCC CTNS BLM PMC5470994__F3 DE genes are significantly overrepresented in the Toll-like receptor signaling pathway TP73 CD3D STAT3 TH ADAR TBK1 PIK3CA FAS MAVS IFIH1 CD46 BBC3 DOK1 IFNG STAT1 EIF3S3 FYN CHUK IL2 MX1 OAS1 IFNA1 CCND1 CD209 IL12A IL13 IRF9 TNFSF6 CTSK IL4 HEL70 IRF3 IRF7 IL6 TNF FOS NFKB1 LIPE JAK1 IFNB1 RCHY1 PMC8310949__F3 WNT3A rs752107(C > T) Polymorphism Is Associated With an Increased Risk of Essential Hypertension and Related Cardiovascular Diseases FRZB APC GSK3B LRP5 LRP6 CTNNB1 PMC5808968__F1 KEGG database illustration of the MAP kinase pathway EGF NGF EGFR BDNF PMC5281575__F1 Metabolic control of macrophage activation ACLY TLR4 IL4 TNF PMC5855670__F2 Death ligand pathway TRADD FADD PMC9007636__F4 Expression Profiles of HOXC6 Predict the Survival of Glioblastoma Patients and Correlate with Cell Cycle COMP MALL GCK HOXC6 CPD ERAS PMC4281031__F3 PI3K-AKT-mTOR signalling pathway and associated hamartoma/overgrowth syndromes (PI3K subsumes PIK3CA and PIK3R2, AKT subsumes AKT1-3) TSC2 PTEN MTOR PMC5812543__F1 Isoprenoid formation IPP PDC IDI1 PMC10420029__F12 mTOR signaling pathway of P SLC3A2 SGK1 GSK3B PTEN FLCN MTOR RHO DEPTOR EIF4E RHEB RICTOR SESN2 RNF152 PMC10420029__F11 Fanconi anemia pathway of P ERCC1 ATR PMS2 BRCA2 FANCM FAN1 FANCL FANCA BLM FANCC FANCB FANCE FANCG FANCD2 FANCF REV1 USP1 HES1 ATRIP POLM RAD51 RMI2 POLI CLK2 UBE2T RAD51C BRCA1 POLK EME2 FAAP24 SLX4 EME1 RMI1 PMC3355730__F2 Co-expression of genes involved in lignin formation across species MYB TRIO CAD SKI PMC7855707__F2 In the absence of IFN (left), constitutively internalized IFNAR1 and IFNAR2 subunits may recycle from the sorting endosome to the PM VPS29 VPS35 IFNAR2 IFNAR1 SNX1 SNX2 SNX6 SNX5 SNX3 PMC8211811__F4 DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma CALD1 MMP14 PXN SNX7 CTHRC1 MRC2 SRPX2 MARVELD1 DCBLD1 TMEPAI OSMR MMP2 GOPC TLN1 ANTXR2 CSGALNACT2 HRH1 ACTN1 CAV2 TNFRSF12A GLIPR1 PDLIM7 LPCAT2 HEL-S-7 PLAUR HEL70 HEL114 LOXL2 BMP1 ITGB1 HEL162 IKBIP PMC6584916__F4 Downstream targets of Slit/Robo ROBO2 ROBO3 CDH2 SLIT2 ROBO1 MYO9B SLIT1 PMC10944040__F1 Molecular mechanisms of IL‐1 release IL1R1 GSDMD NLRP3 TAB3 TRAF6 IL1B MYD88 PMC6584916__F1 Structure of the Slit/Robo protein family and their interaction ROBO2 ROBO3 ROBO1 ROBO4 PMC10944040__F3 Antagonism of IL‐1 signaling pathway IL1R2 IL1R1 IRAK4 MYD88 PMC3409287__F3 ITIM-mediated signaling function of IDO FYN IDO1 RELB IRAK1 SOCS3 PMC6584916__F7 Roles of Slit/Robo in angiogenesis SLIT2 UNC5B ROBO1 ROBO4 PMC5480214__F2 Summary of ergot-alkaloid biosynthetic pathways with emphasis on Clavicipitaceae PMC10944040__F2 IL‐1 signaling pathway IL1R1 IRAK1 IRAK4 IL1B MYD88 PMC6584916__F6 Roles of Slit/Robo in neurocyte navigation ROBO2 ROBO3 DCC ROBO1 SRC FLRT3 PMC6584916__F5 Upstream regulatory molecules of Slit/Robo ROBO2 ROBO3 SUZ12 EED SLIT3 USP33 SLIT2 PML EZH2 ROBO1 PMC7176443__F3 Functional lncRNAs in signaling pathway CDC42 RELA ARHA RAC1 PMC12234997__F5 Protein-protein interaction (PPI) network analysis related to IMP and IMF and identification of their major effect genes OGT ND4L NDUFB11 CARNS1 AMPD3 IL33 PRKCZ PPP3CA COX6A2 ASPA ITGB6 PYGL INHBB ANGPT1 HEL-S-20 CCNG2 HEL-S-29 NDUFS6 COL4A2 NDUFB1 COL4A1 NRAS PDE4D ND2 MDM2 CPT2 GPT LPL RYR2 CASP9 NOS2 EFNA4 PFKFB4 ATP6V1F CRKL GPT2 IRF1 IL7R VEGFA CCL14 GPAM ENO3 FBP2 PLCB1 MAP3K5 ALDH3B1 CXCL9 CXCL12 COX1 CD36 PIK3R3 NDUFA6 ELOVL5 ATP6 ABAT ALDH2 NTF4 HDDC3 ADCY6 PFKM IL1B HEL-S-19 SGK1 LAMTOR3 KCNMB4 GADL1 HEL-S-30 LIPG CYB IL2RB FOXO3A ACVR1 PPP2R2A ACKR4 FGFR3 ACADL CAMK2G BCL6 PMC7998429__F3 Nail organ markers and the requirement of the bone morphogenetic protein (BMP) signaling in proper nail development and differentiation LORICRIN PHLDA1 LGR6 PMC5822808__F1 Overview of Hippo-Yap signaling pathway LATS1 LATS2 NF2 PMC4709767__F6 Proposed pathways by which NRG-1 stimulates GSH synthesis and Cbl metabolism NRG1 CBL PI3 PMC11697911__F7 Graphical overview of the canonical role and potential regulatory mechanisms of the Notch signaling pathway on porcine oocyte maturation HES2 HEY2 DLL4 JAG2 DLL3 HES1 PMC3346990__F3 The potential molecular mechanisms of crosstalk between nuclear receptors LXR and FXR–SHP–LRH-1 regulatory cascade in the liver and intestine FGF8A CYP7A1 FGFR4 PMC6013567__F2 Activation of the anticipatory unfolded protein response by estrogen receptor A (ERA) EEF2K EEF2 EIF2A PMC3623797__F7 Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells MAVS NLRP3 TRIM25 TLR3 IFNAR1 IL1B PMC4212479__F1 Sphingolipid metabolism CERS3 CERS5 CERK SMS tmp_locus_29 CERS2 PMC9650140__F1 Pathology and molecular mechanisms of Schistosoma japonicum-associated liver fibrosis STAT3 COL1A1 BMP7 SKP2 PMC4875603__F6 Expression of genes that function in leukocyte activation in uninfected fetuses CD209 SAA1 TG INHBA MPZ NPPA BPI RBP4 MMP9 PMP2 HAVCR1 SPP1 PMC8450769__F10 Albuca Bracteate Polysaccharides Synergistically Enhance the Anti-Tumor Efficacy of 5-Fluorouracil Against Colorectal Cancer by Modulating Beta-Catenin Signaling and Intestinal Flora PCNA CCND1 CTNNB1 PMC6770018__F6 The key carbohydrate metabolic pathway and the miRNA–mRNA interactions in dmc TREH GIP GPT PMC9346324__F2 Retrospective analysis of endocrine disease in sphingosine-1-phosphate lyase insufficiency: case series and literature review CERS3 CERS5 SMS CERS1 CERS2 PC CERS6 PMC6263089__F4 MTOR/S6K intracellular signal transduction pathways in the osteoclast CDC42 TSC2 BAD NEK6 TSC1 MTOR SRC TRAF6 TNF TRAF2 RAC1 EIF4E PMC3467356__F1 Regulatory network analysis of the top genes with SNPs with p<0.001 using MetaCore’s shortest pathway algorithm (GeneGo Inc.); the nodes that are circled are the genes of interest NR1i1 EGR1 PTPRO SP1 IRF8 PMC9279119__F3 Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer PTEN NLK MMP9 CCND1 PMC4113827__F2 TLR4 signaling pathway TLR4 CD14 IRAK1 TRAF6 LBP IRAK4 PMC2944875__F2 Gene Expression Study of Monocytes/Macrophages during Early Foreign Body Reaction and Identification of Potential Precursors of Myofibroblasts TH EGF JUN THBS1 IL3 TNF FOS SKI IFNG ENG INHBA TOB1 NOG CREBBP IL7 EP300 ZEB2 TEF PMC3560666__F7 Pathway in MAS and differentially expressed genes: as shown in Figure, IGSF4, PTPRC (CD45) and CD3D belong to a family of cell surface adhesion molecules CD226 CD3D BIRC6 CSF2 CSF1 ELL AZU1 PTPRC ANXA1 MPO CD24 BCL2L1 CBLC PROK2 HBD CSK TPO IL1B BIRC3 PMC7188750__F4 Application of microbial extracellular carbohydrate polymeric substances in food and allied industries PMC8821549__F3 TR-binding and regulation of genes in the hedgehog signaling pathway in intestine based on ChIP-Seq and RNA-Seq data EVC SPOP HHIP KIF7 SUFU BCL2 SMO PMC4735514__F2 Activation of the methylation cycle in cells reprogrammed into a stem cell-like state PEMT CTH HEL-S-61p PMC9558279__F1 PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond GNAS PTH MEF2C PMC8304173__F4 Therapies Targeting Metabolic Pathways in Cancer Stem Cells ACLY STAT3 ALOX5 SLC27A3 FASN HEL-S-5 CPT2 PMC8304173__F2 Therapies Targeting Metabolic Pathways in Cancer Stem Cells MEIS1 ENO1 HEL-S-87p MYC KRAS PMC4307326__F5 Some possible signaling pathways activated by SF-CSNPs which may regulate metabolism of proliferating cells through Ubiquitin C (UBC) CD40 EGFR RIPK1 TRAF3 MDM2 MTOR EIF4E PMC4307326__F4 Protein–protein interaction pathways are illustrated CEP250 CDC2 ARID1A PIK3CA BIRC6 UBC ACIN1 MTOR PMC5358695__F4 Layered network between rituximab and myasthenia gravis (MG) BAX IL10 FCGR2B C2 FCGR3A HLA-DRB1 FCGR2C HLA-DRB3 IL6 FCGR1A TNF FCGR2A PMC5358695__F3 Identifying myasthenia gravis (MG) risk genes regulated by drugs and miRNAs in the hsa05200 pathway CRK RARA RAN APC CRKL SMO IL6 INS PMC5358695__F6 Layered network between sunitinib and myasthenia gravis (MG) MAX FLT3 LTA FAS TGFBI BRAF CR2 PTEN MYC IFNG FLT4 NRAS KDR BAX ERBB4 KIT CD55 VEGFA KRAS HRAS CNTFR PDGFRA ADRB2 CCR4 BCL2 PMC5358695__F5 Layered network between adalimumab and MG FCGR3B BAX IL10 FAS FCGR2B C1S BRAF IL6 TNF KRAS HRAS IFNG HLA-DRA C2 FCGR3A HLA-DRB3 HLA-C FCGR2A PMC3427262__F1 Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease IGF1 ATG12 FOXO1 BCL2 ATF4 EIF2A ATG5 TRAF2 PMC5358695__F7 Layered network between muromonab and myasthenia gravis (MG) CD3D FAS PDCD1 BRAF CR2 IL2RA MAPK14 HLA-DRA FCGR2C IL2 FCGR2A BAX IL10 FCGR2B IL4 CTLA4 IL6 TNF KRAS HRAS ICOS FCGR3A HLA-DRB3 HLA-B CD3G HLA-C HLA-A CD3E PMC8875223__F1 Cellular Metabolism during Candida-Host Interactions FAS NLRP3 HEL-S-162eP PLG ENO1 FOXP3 MYC PMC11666815__F1 Schematic illustration of the natural compound–induced protective effects against CVD damage through AMPK/SIRT1/PGC‐1A signaling pathway TFAM NLRP3 NRF1 PMC8811971__F1 IKK-mediated CYLD phosphorylation and cellular redox activity KEAP1 RIPK1 CYLD PMC3152294__F1 Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism HEY2 NOTCH2 NOTCH3 HES1 NOTCH1 HES5 PMC5671973__F1 Recognition of human immunodeficiency virus 1 (HIV-1) by innate immune system MAVS TLR3 IRF3 IRF7 TLR7 TRAF6 MYD88 PMC10036758__F1 The complosome in health and disease C6 FH C7 MASP2 HEL-S-62p C2 C1S VTN CR2 CD46 C4B_2 PMC1448211__F7 Real time pathway analysis of cell-cycle related genes mediated via TS overexpression in HCT-C18 (TS+) cells using actual gene expression data ATR COPE APP PMC11033207__F10 Redox signaling and skeletal muscle adaptation during aerobic exercise HIF1A PECAM1 NOX4 SIRT1 PMC9633954__F2 Pattern recognition receptor signaling and innate immune responses to schistosome infection SYK NLRP3 IL16 PMC9101426__F2 Copy Number Alterations as Novel Biomarkers and Therapeutic Targets in Colorectal Cancer STAT3 PIK3CA HGF SMAD2 SMAD4 ERBB2 MTOR JAK1 MYC KRAS PMC3117317__F3 NFKB signaling pathway CD40 EGF NGF TGFA LTBR BCAN RELA RELB TNF LCK PMC7137714__F6 Identification of microRNA-mRNA regulatory networks and pathways related to retinoblastoma across human and mouse BIRC5 ESPL1 E2F2 BMP4 TTK CDKN2D IL6 CCND1 BIRC3 PMC2662580__F1 Wnt therapy for bone loss: golden goose or Trojan horse? APC WNT1 CCND1 WIF1 CTNNB1 PMC7539779__F6 Mechanism by which SLFN5 regulates BRCA progression SLFN5 PTEN PMC9184225__F6 Improvement of Biosynthetic Ansamitocin P-3 Production Based on Oxygen-Vector Screening and Metabonomics Analysis MAL GIP CIT PMC5686191__F8 Possible mechanisms underlying how YAP regulated LRP1 by promoting proliferation and metastasis of melanoma cells and also reducing apoptosis MMP2 MMP9 PMC3459659__F1 Lipopolysaccharide/TLR4 signalling lipopolysaccharide recognition.Notes: Overview of LPS/TLR4 signalling LPS recognition is facilitated by lipopolysaccharide-binding protein and CD14, and is mediated by TLR4/MD-2 receptor complex TIRAP TLR4 CD14 LBP MYD88 PMC3762672__F1 PI3-K signaling.Notes: Activation of class I PI3-K via RTK phosphorylates and activates downstream target PDK1, in turn phosphorylating AKT kinases at the threonine site RHEB RPS6 TSC2 TSC1 PTEN EIF4E PMC8151225__F9 3,3′-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis CDH2 BAX PMC4364827__F3 Activation of the DNA damage response (DDR) after DNA double-strand breaks (DSB) induction in young and old cells RNF168 H2AX RNF8 ATM BLM PMC4454381__F4 Regulation of autophagy by protein post-translational modification OGA OGT HTT PMC150988__F1 JAK-STAT signaling and the generation of Th1 and Th2 cells STAT4 JAK1 PMC3648520__F1 Roles of DNA Helicases in the Mediation and Regulation of Homologous Recombination RAD52 RAD51 BRCA2 IL1A BLM FBXO18 RMI1 PMC4835209__F8 Conceptual schematic of the miRNA signal pathway regulated by TGFB2-OT1 in autophagy and inflammation ATG3 CERS1 FKBP1A LARP1 RELA NUPR1 SQSTM1 IL6 MTOR NAT8L TIA1 IL1B PMC8957988__F2 An Update of Long-Noncoding RNAs in Acute Kidney Injury PTEN PMC7429250__F3 Hypoxia-mediated glucose metabolism promotes dynamic O-GlcNAcylation of G6PD facilitating the utilization of PPP to produce NADPH for ROS detoxification OGT NOX4 VHL PMC6507272__F3 Role and expression of proteins identified by proteomic analysis within NAD+ metabolism and signaling pathway NAPRT NUDT12 NMNAT2 NAMPT NMRK2 NNMT PNP NMRK1 NADK NADK2 NNT ASPDH NMNAT3 PMC11657277__F9 Function and mechanisms of Chiglitazar in CML cells PFKP HK2 MTOR PMC9602982__F2 Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System HMGCR DHCR7 PMC3370667__F1 Schema of the FUS1 pathway BAX CASP9 EGF EGFR MDM2 APAF1 PMC6090437__F7 Kyoto Encyclopedia of Genes and Genomes pathway analysis of the hub gene secreted LY6/PLAUR domain and its connected genes RAD21 LIN54 CDK7 CDKN1A HEL-S-130P ORC6 GADD45A KHDRBS1 AKAP9 PMC8482240__F3 Comprehensive Proteomic Analysis of Colon Cancer Tissue Revealed the Reason for the Worse Prognosis of Right-Sided Colon Cancer and Mucinous Colon Cancer at the Protein Level MAX C8G C7 MASP2 HEL-S-62p CFD SPARC VTN TWIST2 MAP4K2 C4A TGFBR1 CFP NFKB1 HSPA2 IKBKB C8A CHUK MAP2K1 MAP3K5 C4B_2 MAP2K3 TWIST1 TRAF2 PMC6368612__F4 Wnt signaling pathway APC GSK3B WNT1 CTNNB1 PMC3532379__F3 Functional “DASE” networks ZNF331 DMBT1 MMP20 USP6 PTTG2 PMC4260922__F2 Transcriptomic Immune Response of the Cotton Stainer Dysdercus fasciatus to Experimental Elimination of Vitamin-Supplementing Intestinal Symbionts ECSIT MYD88 PMC8217552__F4 Autophagy induction limits SARS-CoV-2 growth in vitro ATG12 ULK1 TFEB EIF5A EP300 SKP2 ATG5 PMC7179076__F2 Wild type (wt) p53 and mutant (mut) p53 expressed in tumor cells on anti-tumor immune responses and inflammation STAT3 IL6 S100A9 CCL17 PMC3152494__F7 The crosstalk between the NOTCH and AKT pathways at the molecular and cellular levels MPL TPO PTEN PMC8630185__F1 Hemodialysis biocompatibility mathematical models to predict the inflammatory biomarkers released in dialysis patients based on hemodialysis membrane characteristics and clinical practices VWF LOX C2 C1S C1R PMC10473147__F2 Neuroinflammation: A Common Pathway in Alzheimer’s Disease and Epilepsy TREM2 GFAP CD68 IL1B PMC9521765__F1 Free-cell therapeutics and mechanism of exosomes from adipose-derived stem cells in promoting wound healing: current understanding and future applications RHEB STAT3 TSC2 TSC1 SMAD2 APC SMAD4 PTEN GRB2 SMURF2 CTNNB1 PMC8027653__F1 BAP1-mediated malignant signaling RBL1 CCNE1 HCFC1 BAP1 CCNA2 CCND1 PMC6158072__F23 Nrf2/AR signaling is at the crossroads of Wnt and Akt/FOXO signaling pathways KEAP1 GSK3B PTEN CTNNB1 PMC7720132__F6 Summary of major impacts of challenge with Vibrio coralliilyticus RE22 and probiotic treatments with Bacillus pumilus RI06–95 and Phaoebacter inhibens S4 on Crassostrea virginica larval immune responses ATG9A TRAF6 PMC9170600__F1 Effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential NRK NAPRT NAMPT PMC9088190__F1 Methods for monitoring cancer cell pyroptosis HMGB1 GSDMD NLRP3 GSDMC WAS GSDMB DFNA5 TNF PMC5943908__F6 Summary of the vasoconstriction signal transduction pathways showing points of intervention by Xyl-B COX1 XYLB PMC8667473__F2 Review: The Role of Wnt/Beta-Catenin Signalling in Neural Crest Development in Zebrafish DKK1 APC GSK3B LRP5 LRP6 PMC8909674__F4 Mitochondrial Stress Response in Cancer Progression ATG101 ATG3 PINK1 ATG12 OPA1 ULK1 BNIP3 FUNDC1 ATG5 ULK2 PMC2658594__F4 AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration SOX9 LRP6 CTNNB1 PMC3549305__F4 GLUTATHIONE SYNTHESIS HEL-S-61p PMC11373551__F8 Identification of core regulatory genes and construction of partial correlation interaction networks related to taurine metabolism pathways ZFP36 CD40 MS4A1 CREB3 CXCL1 APC PTGS2 DROSHA FYN CD74 APP CCL4 LCK PMC6468754__F1 Hypoxia inducible factor (HIF) and vascular endothelial growth factor (VEGF) link the angiogenesis signaling pathways VCAM1 PMC8482240__F7 Comprehensive Proteomic Analysis of Colon Cancer Tissue Revealed the Reason for the Worse Prognosis of Right-Sided Colon Cancer and Mucinous Colon Cancer at the Protein Level CPA3 CHL1 CTSA CTSZ CTSG ACADM SEC11C THOP1 CMA1 GM2A MME HEXA PADI2 PRCP NLN RNASET2 FABP2 CTSO CPM PSAP ACE2 PMC5677954__F6 Osteoblastic differentiation-related molecular mechanism under combined cytokine treatment SMAD1 DKFZp781O1323 IGF1 BMP2 PTEN MTOR RUNX2 CTNNB1 PMC4875603__F4 T Cell Receptor (TCR) signaling pathway activation in endometrium of UNINF fetuses TEC FYN SHB SP1 LAT CSK GRB2 RAC1 LCK PMC8299113__F1 Gold Nanomaterials and Bone/Cartilage Tissue Engineering: Biomedical Applications and Molecular Mechanisms BMP2 RUNX2 CTNNB1 PMC8081922__F5 Beta-Catenin mediates glucose-dependent insulinotropic polypeptide increases in lysyl oxidase expression in osteoblasts LOX GIP GIPR CTNNB1 PMC4130595__F3 Identifying a Polymorphic ‘Switch’ That Influences miRNAs' Regulation of a Myasthenia Gravis Risk Pathway IGF1 BCL2 IGF1R KRAS PMC8169871__F2 Alterations in brain metabolite concentrations and brain gene expression in AD CYP51A1 SQLE SC5D DHCR24 MVK HMGCS1 HMGCR ACAT2 CYP7A1 CYP11A1 WAS PMVK CH25H MVD CYP46A1 DHCR7 FDPS FDFT1 CYP3A4 TM7SF2 CYP27A1 PMC5490603__F3 Anti-inflammatory signaling pathways influenced by free zinc HEL164 SMAD1 DKFZp781O1323 SMAD2 JAK3 SMAD4 IL2RA PTEN JAK1 PMC5490603__F2 Pro-inflammatory signaling pathway influences by zinc STAT3 TRADD IRAK1 IRAK2 FOXP3 TRAF6 MYD88 PMC5490603__F1 Activation of Toll-like receptor (TLR) signaling pathways is mediated by a complex array of proteins TIRAP TLR9 IRAK1 TLR5 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR1 MAP3K7IP1 TLR4 TLR7 IL1B PMC7288943__F8 Schematic diagram showing the mechanisms by which S58 promotes antioxidant defense of HConFs against fibrosis TGFBR2 GPX1 PMC8923649__F5 Correlation of SARS-CoV-2 to cancer: Carcinogenic or anticancer? (Review) TMPRSS2 BAD PTEN ACE2 PMC7868705__F1 Noncanonical NFKB Signaling Pathway in Liver Diseases LTB RELA RELB TRAF3 IL1B PMC2679904__F1 TLR mediated signaling TBK1 TIRAP IRF2 TAB3 IRAK1 IRF3 TRAF3 TRAF6 IRAK4 MYD88 PMC8969450__F2 Platelet-leukocyte crosstalk in COVID-19: How might the reciprocal links between thrombotic events and inflammatory state affect treatment strategies and disease prognosis? TMPRSS2 STAT3 SYK HEL-S-62p TLR9 TRAF6 IRAK4 MYD88 PLCG2 TLR4 TLR7 ACE2 IL1B PMC7794007__F1 Diagrams depicting the Sestrins-mediated stress signaling pathways and functional domains of Sestrin2 in the regulation of metabolism and disease RBX1 KEAP1 ULK1 RNF186 IRS1 PMC3874163__F8 A simplified view of siRNA-enhanced DNA-mediated IFN-λ1 signalling pathway TBK1 MAVS IFI16 IRF3 PMC8473587__F1 p53 regulates glucose, lipid, amino acid, nucleotide, and iron metabolism SLC25A28 FDXR FXN PANK1 RRM1 HK2 RRM2 HAMP SLC7A11 TIGAR PDK2 MYC PCK1 PCK2 SCG2 SLC7A3 PHGDH CROT F2 FES ASNS PMC6925522__F2 LRRK2 and inflammatory signalling NLRC4 NAIP LRRK2 TLR4 TRAF6 TNF RCAN1 IL1B PMC3148026__F2 Pathway alterations involved in the development of low-grade serous carcinoma BRAF MTOR KRAS CCND1 PMC11939912__F2 Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders BAD RHO GRB2 SHE BDNF PMC11939912__F3 ProBDNF/p75NTR reverses the effects of BDNF/TrkB signaling, which activates the mTOR pathway to control actin remodeling and spine protein production, hence weakening dendritic spines [115] EIF4B ARHA MTOR BDNF EIF4E PMC3077082__F6 Microbial manipulation of receptor crosstalk in innate immunity STAT3 TLR4 MYD88 PMC12000012__F3 Divergent regulatory pathways in moderate erythropoiesis and excessive erythrocytosis FAS EPOR EPO CSNK2B PMC3077082__F4 Microbial manipulation of receptor crosstalk in innate immunity TLR1 CD47 RAC1 PMC12000012__F5 Pathogenetic cascade of HAPC FAS GATA1 SENP1 EPO IL6 RET PMC3077082__F3 Microbial manipulation of receptor crosstalk in innate immunity TLR4 GSK3B CXCR4 PMC12000012__F4 Hypoxia-regulated iron homeostasis and erythropoiesis TF ERFE TFR2 EPOR EPO ALAS2 PMC3077082__F2 Microbial manipulation of receptor crosstalk in innate immunity TH SYK RAF1 CLEC5A IL6 ARHA TNF MYD88 PMC3077082__F1 Microbial manipulation of receptor crosstalk in innate immunity SYK CEACAM1 HLA-E MARCO PMC10723408__F1 Workflow and methodology used in this work VIT EMD SET CIT PMC7835030__F7 NLRC4 gene regulates inflammatory reaction and immune response of DCs in septic shock by mediating the NLR pathway NLRC4 CD80 NOD2 NOD1 IL1B PMC8057295__F1 SHH pathway in the (A) absence or (B) presence of the SHH ligand KIF3A GPR161 HHIP GSK3B ADRBK1 SMURF1 SPOP KIF7 SUFU PTCH1 SHH SMO SMURF2 GLI3 PMC3852078__F6 BDNF-related PPI network ELAVL2 UBC ELAVL1 BDNF PMC8057295__F2 Schematic presentation of upstream regulation of the SHH signaling pathway and its associations with other cancer-related cellular pathways EGF CDC73 SHH HIF1A FOXA2 MTOR E2F5 ZIC2 CTNNB1 RORA PMC8144890__F3 Energy metabolism disorders and potential therapeutic drugs in heart failure RHEB TSC2 TSC1 F2 TBC1D7 PMC8057295__F4 Models of the SHH signaling pathway in cancer SUFU PTCH1 SHH SMO PMC9573421__F5 Phytochemicals in Skeletal Muscle Health: Effects of Curcumin (from Curcuma longa Linn) and Sulforaphane (from Brassicaceae) on Muscle Function, Recovery and Therapy of Muscle Atrophy RBX1 KEAP1 IL1B PMC7508496__F2 BMP 7/Signaling Antagonizes TGFB−Induced Organ Fibrosis: MechanismBMP-7 and TGFB1 bind to distinct type II receptors that form complexes of specific type I serine-threonine kinase receptors TF SMAD1 DKFZp781O1323 SMAD2 PMC3976861__F2 Representation of the p53 signaling pathway map from KEGG RFWD2 BAX RAN ATM PMC4442748__F1 M1 and M2 Immune Activation in Parkinson’s Disease: Foe and Ally? SOCS1 STAT3 SYK JAK3 ARG1 JAK1 TNF TYK2 IL1B PMC6275025__F1 Insulin signalling pathway GSK3B IRS4 PTEN IRS1 PMC5302945__F3 Seven protective miRNA signatures for prognosis of cervical cancer ARID1A SUZ12 MYB EED EZH2 PTGS2 VEGFA MYC FOS SOX9 PRKDC ATM EP300 NOTCH3 NOTO PMC2593123__F1 A simplified schematic of the core left-right signaling pathway in the e8.5 (6 somite) mouse embryo LEFTY1 LEFTY2 NODAL PMC6981493__F5 Representation of the cellular response after insulin stimulation BAX BAD GSK3B PMC7443512__F5 Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission TMPRSS2 ACE2 PMC8719288__F1 Building Resilience with Aerobic Exercise: Role of FKBP5 GC BDNF PMC5456285__F6 HCoVs on ER stress response ATF4 EIF2A XBP1 PMC9929940__F5 Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern CD40 IFNG ICOS CD80 BCR CCR7 CXCR5 CD1D CCL17 PMC5456285__F5 HCoV viral proteins on innate immunity STAT1 MAVS STAT2 IRF1 IRF3 JAK1 TYK2 MYD88 PMC6900528__F6 The proposed pathway of IPs synthesis ITPK1 IPMK PMC7443512__F2 Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission NLRP3 TLR3 TLR8 IRF3 IRF7 TLR7 TNF IL1B MYD88 PMC8849228__F8 Transcriptome Profiling During Muscadine Berry Development Reveals the Dynamic of Polyphenols Metabolism C6 COA3 TCP1 CAD AGL CS PMC10433440__F6 (A and B) Illustration of classical and non-classical Wnt/Beta-catenin signaling pathways APC CTNNB1 PMC6882007__F1 Hh signaling pathway transduction KIF7 SUFU SMO PMC2814417__F7 The postulated signaling of MAP kinase pathway in proliferating or differentiating HL60 cells NR1i1 EBP KSR1 CD14 PMC5342665__F1 Steps in the LDLR metabolic pathway PCSK9 LDLR PMC7287178__F2 Proposed model of the cardiac sarcostat NBR1 HEL-S-101 CA3 BAG3 HEL55 HSPB8 PMC4982475__F6 Simvastatin and dLGG mediate formation of oxylipin mediators by regulation of MAPK-induced cPLA2 activation and downstream signaling cascades LTA LOX LBP PMC3841149__F9 WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation PTCH1 LRP5 SHH LRP6 SMO WNT3 CTNNB1 PMC9090832__F7 Olig2-Ddx20 axis-mediated suppression of p53 pathway GEMIN2 GEMIN5 GEMIN6 OLIG2 GEMIN7 GEMIN8 MDM2 PMC7797087__F1 Schematic model illustrating the cross-talk between the ET-1R axis and the YAP pathway TF SRC PMC6881651__F10 The Action circTTN Competitively Sponging miR-432 Mediating Myoblast Proliferation and Differentiation MYOG MYOD1 PCNA MYF5 CDK2 CCND1 IGF2 PMC7764760__F2 An EGFR-centric view of EV biogenesis EGF EGFR GRB2 CP PMC11352233__F7 HER2/epidermal growth factor receptor (EGFR) signalling pathway in breast cancer EGFR SMAD2 SMAD4 PMC7764760__F3 Pathway diagram of EGFR post-endocytic fate EGF TGFA PLD2 EGFR ARF6 BTC TSG101 ARHA RHO PMC5954861__F3 TBP-2 snd p38 MAPK-NFKB signaling pathway POR COX2 TBP OPTN S100B PMC12110717__F2 Schematic view of membrane channels, Ca2+ and inorganic phosphate (Pi) ion trafficking and amorphous calcium phosphate (ACP)/HA formation TMCO1 PANX3 PMC7768823__F1 Actionable nodes of the autophagy pathway ATG101 ATG10 ATG3 ATG12 ULK1 AMBRA1 ATG5 ULK2 PMC5954861__F6 TBP-2 regulates autophagy and apoptosis of HLECs under oxidative stress BAX CASP3 MTOR TBP PMC10917928__F2 TCM polysaccharides’ role in regulating tumor adaptive immune response SYK BCR MAK PMC10917928__F1 TCM polysaccharides’ role in regulating tumor innate immune response TLR4 CD14 TANK TRAF6 MYD88 PMC5068743__F5 Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis CDC2 UBE2V2 PSMB6 HEL-S-107 FOLH1 UBR5 MTDH TXLNA ADAM9 ATF4 DHRS1 CKAP5 OTUB2 VCPIP1 STEAP2 PMC4409326__F2 MicroRNAs in the pathogenesis of cystic kidney disease DGCR8 DROSHA PMC8599717__F2 Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology XRN1 WTAP YTHDF2 CCR4 YTHDF1 METTL3 PMC8289871__F10 Cartoon depicting the putative molecular mechanism for insulin protection of pancreatic acinar cells during acute pancreatitis F2 GLA ADA PMC11040167__F6 Nrf2/ARE pathway as a potential target to ameliorate atrazine-induced endocrine disruption in granulosa cells ATR KEAP1 MAF PMC10140937__F4 Mitochondrial DNA Supplementation of Oocytes Has Downstream Effects on the Transcriptional Profiles of Sus scrofa Adult Tissues with High mtDNA Copy Number FH CS TRAF3 HLA-DQB1 SDHD ME3 CAP2 HLA-DRA OGDH ME2 SUCLG2 DLD MDH2 SDHC PMC7103059__F3 Signaling pathways in osteoclast activation CD80 MMP9 SRC TRAF6 TRAF2 FOS PMC3585436__F3 p110D PI3K pathway in B cells CD40 SYK BTK CXCL13 BCR PLCG2 TLR4 CD14 IL4 CXCR5 CD19 LYN PMC3585436__F2 Simplified scheme showing the critical role of Class IA PI3Ks in multiple cellular functions RHEB TSC2 BAD TSC1 GSK3B PTEN PMC3585436__F4 p110D PI3K mediates the effects of CSF-1 or EGF via RhoA and PTEN in macrophages and some solid tumor cells EGF PTEN ARHA SRC PMC3680388__F5 Novel Strategy to Increase the Proliferative Potential of Adult Human Beta-Cells While Maintaining Their Differentiated Phenotype STAT3 WNT3A SMAD2 GSK3B SMAD4 UGT2B10 TCF4 ACTA2 COL4A1 NKD1 UGT2A2 FZD2 TET1 LRP5 FZD7 RUNX3 SFRP1 NPC2 RRH MCM10 RUVBL1 PDGFRA DVL3 WNT3 JAK1 UST TYK2 PMC5608693__F6 Model of step-wise progression in DPN-like melanoma TET2 ARID1A CDKN2A APC BRAF TERT CTNNB1 PMC2727867__F1 Representation of some zinc-induced apoptotic pathways C2 F2 F3 PMC6007054__F8 Diagram showing effects of 4-HNE on Keap1- and GSK3Beta-mediated Nrf2 degradation KEAP1 GSK3B PTEN PMC10976824__F2 Infection of endothelial cells by pathogenic microorganisms triggers the activation of the NFKB pathway, resulting in increased levels of HIF-1A SYK TRADD MAVS MAL TNF TRAF6 IRAK4 MYD88 TLR1 BCL10 TLR4 RIPK1 SRC TRAF2 CARD9 PMC3926505__F3 Roles of Cu in synaptic function ATOX1 PSD ATP7A PMC3926505__F1 Key organelles and proteins involved in cellular Cu homeostasis ATOX1 CCS APP BDNF COX17 HEL-S-44 ATP7A PMC5819894__F11 Metabolic enzymes targeted by p53 HK2 SCO2 PMC4414174__F9 Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer TRAF4 MTOR TRAF2 PMC6963500__F9 Activation of the Wnt/Fz ligand-receptor leads to the production of the second messengers IP3 and DAG from membrane-bound PIP2 via the action of membrane-bound enzyme PLC CASR BMP2 RUNX2 PMC9420645__F1 Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer's Disease TIRAP TLR4 TAB3 IRF3 IRF7 TRAF3 TRAF6 MYD88 PMC4831844__F2 Computational Reconstruction of NFKB Pathway Interaction Mechanisms during Prostate Cancer PTX3 RRAD LIF IRF1 PTGS2 AREG CXCL3 GPR17 SNAI1 STX11 RELA BMP2 IER2 PMC8817839__F2 CGRP: A New Endogenous Cell Stemness Maintenance Molecule TRPV1 SHH AQP5 PMC7746538__F2 Cathepsins in macrophage functions during bacterial infection LAMP2 NLRP3 TLR3 HEL-S-130P CTSL CTSK IRF3 CTSS EEA1 MYD88 PMC4922528__F2 TLR and NLR signaling TIRAP CD14 IRAK1 TLR5 IRF3 IRAK2 TRAF6 IRAK4 MYD88 TLR1 NLRP3 TLR3 TLR4 TLR7 IL1B PMC3827948__F6 S4 controls FGF2-mediated signaling through RhoG-dependent macropinocytosis of the FGFR1-S4-FGF2 signaling complex ARHG FGFR1 FGF2 PMC9604716__F3 LL-37 in Bone and Periodontium Regeneration TLR4 EGFR FPR2 IGF1R PMC8386479__F7 Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming PMC12044029__F6 Bone-derived factors regulate renal functions CYP27B1 SOST SGK1 DKK1 LCN2 FGF23 PMC6305653__F2 Signaling pathway analysis of KEGG and PANTHER pathways shows that the miR‐34a/BCL‐2 axis is mostly involved in apoptotic pathways BAX CASP9 BAD FAS CASP8 TRADD IL3 CASP12 MYD88 CASP6 CASP3 ATM HEL-S-11 TRAF2 FADD PMC9656419__F3 Intestinal Flora Derived Metabolites Affect the Occurrence and Development of Cardiovascular Disease STAT3 STAT1 MYC PMC8377544__F5 Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man UCP2 TSC2 TSC1 FOXO3A PTEN NOX4 SIRT1 PMC9257083__F6 Gut Microbiota-Derived Diaminopimelic Acid Promotes the NOD1/RIP2 Signaling Pathway and Plays a Key Role in the Progression of Severe Acute Pancreatitis DAP NOD1 TNF PMC8377544__F4 Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man EGFR GSC PMC2917144__F1 Toll-like receptor signaling pathway HEL-S-71 TBK1 MAP3K7IP1 TIRAP TLR4 TAB3 IRAK1 IRF3 TRAF6 IRAK4 MYD88 PMC3772104__F2 Involvement of the JAK-STAT signaling pathway in chronic inflammatory skin disease atopic dermatitis IL19 CCL24 CCL26 JAK1 PMC3772104__F1 The involvement of the JAK-STAT signaling pathway in chronic inflammatory skin disease atopic dermatitis LORICRIN JAK3 FOXP3 JAK1 GATA3 PMC6947643__F2 The gamma secretase (Gamma-secretase) complex: It is comprised of presenilin enhancer (PEN-2), anterior pharynx-defective 1 (APH1) and nicastrin ADAM17 ADAM10 HES1 PMC11734646__F9 SCF involves in the regulation of immune response FBXO3 PKD1 FBXO21 FBXW11 AIRE FBXL19 PMC5802154__F8 Intracellular signaling mechanisms that induce epithelial mesenchymal transition during CSE-induced aberrant EGFR activation in human RPE cells RPE SYK TGFB1 SRC PMC8286839__F8A Figure 8.NFKB dependent inhibitory feedback at the receptor level CSA2 TLR4 CD14 PMC2610366__F1 Pathways involved in folate-dependent methionine transmethylation and transsulfuration PMC4945639__F2 WNT/Beta-catenin signaling pathway in adrenal tumorigenesis APC GSK3B LRP5 ZNRF3 LRP6 CTNNB1 PMC9313047__F3 Pathological Features and Neuroinflammatory Mechanisms of SARS-CoV-2 in the Brain and Potential Therapeutic Approaches TH TLR3 CCL4 CCL2 ACE2 PMC7281661__F6 LAB-mediated modulation of inflammatory responses in bovine mammary epithelial (BME) cells TLR4 SIGIRR CXCL2 IL1A CXCL3 MYD88 PMC4298363__F7 Suppression of ghrelin signaling mitigates age-associated thermogenic impairment GHSR OPA1 COX2 MFN2 UCP1 IRS1 PMC6835776__F3 Proposed effects of ZnO nanocomposites on antigen-presenting cells and their potential role in inducing T cell responses in draining lymph node IFNG NPS MYD88 PMC8529605__F5 Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking POR HEL-S-133P RHOD BPI FBL EPO PFKL DAO VHL PMC7504796__F3 Interdependence of CAT:MST axis, glutathione (GSH) bioavailability and cysteine metabolism HEL-75 PMC7504796__F1 Role of the glutamate oxaloacetate transaminases: 3-mercaptopyruvate sulfurtransferase (CAT:MST) axis in promoting and sustaining cancer MCAT KEAP1 KRAS PMC9340905__F1 Next-generation selective estrogen receptor degraders and other novel endocrine therapies for management of metastatic hormone receptor-positive breast cancer: current and emerging role ENG CDK6 EGFR MTOR CCND1 CDK4 PMC9409144__F1 Oxidised Low-Density Lipoprotein-Induced Platelet Hyperactivity—Receptors and Signalling Mechanisms SYK FYN CD36 PDE3A IRAK1 LYN ARHA IRAK4 UNK SRA1 MYD88 PMC3123543__F4 Overlaid networks predicted by the PLS method and generated by IPA pathway designer TES EREG MIDN ELF2 PMC1297640__F1 Systems and molecular complexity in glycobiology GAL GNE FPGT KY GFPT1 NAGK GCK CD34 PMC9262756__F2 Aberrant expression of miRNAs in epilepsy HEL-S-92n DLL4 APC ADAM10 NOTCH2 NOTCH3 DLL3 HES1 NOTCH1 HES5 PMC3233204__F4 DEVELOMENT AND NEUROGENIC POTENTIAL OF MÜLLER GLIAL CELLS IN THE VERTEBRATE RETINA CCND3 EGF RAX PMC6457004__F5 Schematic model in which HMW FGF2-mediated FGF23 stimulation of chondrocyte differentiation and OA is partially through modulation of the Wnt/Beta-catenin pathway SOST ADAMTS5 WNT7B AXIN2 CTNNB1 FGF2 FGF23 PMC6103261__F1 Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays LTB LTA COX1 PC PMC5921900__F2 Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges CXCL12 CCL22 CCL28 CSF1 CCL2 CCL17 PMC4110655__F2 Proposed mechanism of action of the erythroid regulator ERFE ERFE EPO PMC8064803__F2 Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma NLRP3 C2 C1S TLR4 MYD88 PMC8300636__F1 Relevance of Plant-Derived Se Compounds to Human Health in the SARS-CoV-2 (COVID-19) Pandemic Era CBL SEPSECS CS HP PSTK PMC8783100__AF1 Secretory pathway Ca2+-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry ATR ORAI1 ATM PMC5161753__F5 Summary of the mechanisms for LAPTM4B promoting cancer development CASP9 EGF LAPTM4B FOXO4 EGFR GSKIP MMP2 MMP9 PMC7677142__F1 Subcellular localization of the cholesterol biosynthetic pathway in mammalian cells BAAT INSIG1 PMC9279817__F7 MiR-20a: a mechanosensitive microRNA that regulates fluid shear stress-mediated osteogenic differentiation via the BMP2 signaling pathway by targeting BAMBI and SMAD6 SMAD1 DKFZp781O1323 BMP2 SP7 SMAD6 SMAD4 RUNX2 PMC10963404__F6 Mode of action of DMXAA and its derivative HHMX in human and mice TBK1 CGAS IRF3 IL6 PMC5732764__F1 Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model AMD1 MTAP SMS SRM SMOX PAOX TYMS PMC2757227__F1 Regulation of ENaC and CFTR by SGK1/Nedd4-2 SGK1 CFTR PDK2 PMC7319342__F7 ROS regulation of RAS and vulva development in Caenorhabditis elegans DUOX2 HEL-S-44 PMC8167992__SF1 Targetable nanoparticle BAF312@cRGD-CaP-NP represses tumor growth and angiogenesis by downregulating the S1PR1/P-STAT3/VEGFA axis in triple-negative breast cancer STAT3 S1PR1 VEGFA PMC8476858__F1 Editorial: Intracellular Mechanisms of Alpha-Synuclein Processing BAG5 HEL-S-130P PTMS PMC7468876__F2 Schematic representation in IPA of the ILK signalling pathway KRT18 JUN HEL113 PXN PTEN MMP9 MTOR NCK2 RICTOR COX2 BMP2 CASP3 LEF1 NACA UNK PMC9377691__F3 Supramolecular organizing centers at the interface of inflammation and neurodegeneration TBK1 CGAS MAVS IRF3 TRAF3 TRAF6 PMC5031543__F3 HGF signaling pathways; A) Representative structures, cMET binding affinities (KD) and dimerization of HGF, NK1 (cMET agonists) and NK2 (cMET antagonists HGF RAF1 PMC5812256__F1 Bile Acids in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis FGF8A CYP8B1 BAAT FGFR4 CYP7B1 CYP27A1 PMC7242157__F1 Metabolic, renal and neural health are impacted by a ketogenic diet CREB3L3 NR1C1 NLRP3 FGF21 MTOR ACE2 PMC7932549__F2 Overexpression of DNA repair genes in invasive ductal and lobular breast carcinomas: Insights on individual variations and precision medicine RFC4 RFC1 MPG RFC2 TERF2 ACD FANCM FANCL FANCA FANCC EYA1 OGG1 FANCE PNKP FANCG EYA2 POLE POLD2 PCLAF MBD4 UBB TDG HUS1 UBA7 ATRIP TINF2 TIMELESS DTL NBN MDC1 BARD1 RBX1 POLE4 LIG1 MRE11A APEX1 EME2 FAAP24 ATR PCNA VCP BLM KPNA2 SUMO1 WDR48 CHEK2 ATM ISG15 BABAM2 CENPX UBC CENPS PARG NSD2 RPA1 POLK RFC3 SLX4 POLN EME1 BRCC3 PMC4650856__F4 Wnt signaling pathway involved in SPN CTNND1 AMACR LEF1 CTNNB1 PMC7985179__F2 Key proteins and interactions in coronavirus disease-related pulmonary fibrosis (COVID-PF) MUSK PTX3 PPARG CD80 GUSB TGFBI CSF1 CGA TGFB1 BUB1B GSK3B VTN FGFR2 ALB WT1 EREG CLU IRAK3 NOD2 DPP4 PRKCA APP ACE2 HEL-S-44 IL1B CGB8 APOE NTRK2 CD40LG VEGFA IL6 FGF10 FURIN TNF NRG1 HMGCR IGF1 PRL NTRK1 FGFR3 CENPA CENPB BDNF TNFRSF11B CD68 CP PMC6079124__F1 Several Proposed important schematic signaling pathways for Gankyrin in tumorigenesis STAT3 RELA IRAK1 PTEN ARHA IL1B CTNNB1 PMC6643872__F2 ETC and ATP synthase are required for normal eye development NDUFB6 NDUFB2 NDUFB5 ND4L NDUFB11 NDUFS5 NDUFV2 NDUFA7 NDUFA13 NDUFAB1 NDUFA10 NDUFS3 COX17 COXFA4 COX2 NDUFS6 ND6 NDUFB4 NDUFB1 COX3 ND3 ND2 ND1 SDHD SDHA SDHB ZNF183 NDUFS1 SDHC NDUFB8 NDUFA12 COX1 COX10 NDUFA9 NDUFB9 NDUFA6 COX7C NDUFS8 NDUFA11 NDUFS4 NDUFB7 NDUFB3 NDUFC2 FH ND4 NDUFB10 CYB ND5 NDUFA2 COX11 NDUFA5 PMC8931059__F3 CD95-dependent non-apoptotic signaling PLCG1 ORAI1 PTEN MTOR PMC8931059__F2 CD95-dependent apoptotic signaling CASP3 FADD PMC11643440__F2 Insulin signaling pathway in adipocytes in healthy and obese (pathologic) subjects FOXO1 FOXO3A F3 PMC12090549__F5 For combining inhibition of the adenosinergic pathway and other cancer immunotherapies APC ADA PMC8143539__F3 Using Pharmacogenetics of Direct Oral Anticoagulants to Predict Changes in Their Pharmacokinetics and the Risk of Adverse Drug Reactions CES1 HP CYP3A4 PMC12090549__F4 Immunosuppressive effects of adenosine within the tumor microenvironment CXCL12 CD80 COX2 TNF PMC7656123__F3 Identification of an important regulatory role for miR-574-3p-mediated signaling pathways (especially the EGFR/RAC1 pathway) in spinal chordoma by integrated analysis of both the miRNA-mRNA and protein-protein interaction networks data NR1i1 EGFR WASL NRP1 SMAD4 IRF4 TNS1 MAPK8 RAC1 CLDN2 MKRN1 HBEGF NEDD4 EPGN P2RY2 RXRA APOB ADAM10 CLTC BCL6 PMC12090549__F1 Adenosine production and signaling pathway PNP ADA PMC7998716__F1 Activation of Tyro3, Axl and MerTK (TAM) receptors on cancer cells results in downstream oncogenic signaling RALB TYRO3 RALA AXL MCL1 RHO MMP9 MERTK PMC8024568__F1 IL-10, 13, 17, and 33 interaction mechanism with their specific receptors STAT3 IL33 JAK1 TRAF6 TYK2 MYD88 PMC10459248__F2 Cellular pathways modulated by ASFV STAT3 CSF2RA CGAS NPC1 ULK1 PPP3CA CD1D TRIM21 KPNA2 CD58 STAT1 IFNGR2 NLRP3 KPNA4 CD163 IFNGR1 IFNLR1 STAT2 IRF9 IRF3 IRF7 LAMP2 KPNA3 IFNAR2 IFNAR1 EP300 VPS39 JAK1 TYK2 IL10RB PMC11890030__F1 Comprehensive strategies for paclitaxel production: insights from plant cell culture, endophytic microorganisms, and synthetic biology IPP SET PMC11890030__F3 Comprehensive strategies for paclitaxel production: insights from plant cell culture, endophytic microorganisms, and synthetic biology MYB ERF IPP MYC PMC9633854__F3 Choroid plexus epithelium and its role in neurological diseases IFNG CP PMC4451983__F2 Functions of lncRNAs in autoimmune cells, T cells, B cells, macrophages, NK, and dendritic cells HNRNPL IFNG STAT3 CCR1 WDR5 PMC5035020__F4 Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection RPEL1 TLK2 GSC NODAL GRB2 SKI PMC5356817__F5 Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm FCGR2B HEL-S-273 LCP2 MYOT TNFSF8 ADRA1A CD14 CTSC MYLK MYOM1 TLR1 LY86 tmp_locus_29 THEMIS2 ROCK1 C1QC AIF1 CYBA IGSF6 ACTG2 PRKG1 PMC7350910__F4 Crosstalk between the TNF-related pathway and CS response GC TNF TNFRSF10A FADD PMC5074868__F8 MYELOID HSF1-Beta-CATENIN AXIS REGULATES NLRP3 INFLAMMASOME ACTIVATION IN MOUSE LIVER ISCHEMIA/REPERFUSION INJURY NLRP3 TLR4 HSF1 TRAF6 IL1B CTNNB1 MYD88 PMC9359082__F2 CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate the tumor microenvironment CMTM6 MTOR SOX21 CMTM4 CTNNB1 PMC6771392__F7 Model of HROB function in homologous recombination MCM9 RAD51 HELQ HROB PMC8268587__F1 Osteoblast Differentiation and Signaling: Established Concepts and Emerging Topics BAMBI SMAD1 DKFZp781O1323 DKK1 APC LRP5 SMAD6 SMAD4 LRP6 CRIM1 CTNNB1 PMC4714567__F6 Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs KLF6 CDK2 AHR CYP1A1 PMC4714567__F5 Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs KLF6 AHR PMC3530773__F3 Vasopressin signaling network GNAS MAPK14 BAD CAMK2A TP53BP2 ASB4 PHKB LRRFIP2 RYR1 MINK1 PMC4714567__F3 Ah Receptor Pathway Intricacies KLF6 RELA MAF AHR CYP1A1 PMC7864232__F7 Diversity and Biology of Cancer-Associated Fibroblasts PTCH1 SHH SMO PMC4714567__F2 Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs BAX PON1 AHR STC2 AHRR PMC7519530__F6 Hypothesized role of miR-142-5p and miR-365a-3p in CML signaling BAX CASP9 SRI BAD ABL2 MCL1 GRB2 MTOR PMC11918467__F6 H2 can protect H9c2 cells from H/R injury by inhibiting the Wnt/CX3CR1 signaling pathway HMGB1 CX3CR1 TLR4 APC CTNNB1 PMC8267696__F1 Metabolic Reprogramming: A Friend or Foe to Cancer Therapy? BAX FAS MCL1 APAF1 FADD PMC8869954__F1 RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart ADRBK1 MAPK14 STAT3 RAF1 GSK3B JAK1 SRC MYC NOTCH1 PMC5332476__F1 The role of Rho GTPase/Rho kinase signaling pathway in regulation of actin cytoskeletal organization and cellular processes in smooth muscle and non-smooth muscle cells LPA ARHA RHO PMC5332476__F2 Inhibitors of Rho GTPase and Rho kinase lower IOP by increasing aqueous humor outflow through the conventional pathway and exhibit neuroprotective effects by stimulating axonal outgrowth and retinal ganglion cell survival HEL-S-62p ARHA RHO PMC9180238__F1 MicroRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor FOXR2 MTDH PTEN MTOR KRAS PMC6797603__F1 NLRX1 regulates immune system signaling NLRX1 MAVS NLRP3 UQCRC2 TUFM TNF PMC4857091__F6 Evaluation of energy metabolism and calcium homeostasis in cells affected by Shwachman-Diamond syndrome SBDS EIF6 MTOR PMC9433407__F9 Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response SLC25A11 F2 SLC25A1 FES HEL-S-26 PMC6235699__F2 NAD+ and sirtuins in retinal degenerative diseases: a look at future therapies NMNAT1 NAMPT NMNAT2 NMNAT3 PMC7323198__F2 Schematic summary of SARS‐CoV‐2 entry into host cells, replication, effect on host cells, and postulated effects of statins TF NLRP3 SKP2 ACE2 IL1B PMC5578165__F1 The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts TOPBP1 RAD51 BRCA1 BRCA2 ATM PMC5645057__F1 TGFB signaling pathway in prostate cancer cells SMAD2 SMAD6 TGFBR3 SMAD4 PMC4100143__F1 Diagram of CD4 T cell differentiation and immunomodulation by the AhR signaling pathway IL-21 HEL-S-92n STAT1 IL10 IL13 IL4 AHR IL2 IL6 FOXP3 TNF GATA3 PMC8458263__F2 RSR blockade stimulates innate anti-tumor immunity through the cGAS-STING pathway IFNG TBK1 IRF3 CCL5 CXCL10 PMC4794670__F4 Network of type I interferon response- and UPR-related genes DBP CREB5 IFIT1 IFIT3 IFIT2 ATF2 ISG20 FOSL2 CEBPG CEBPD BATF3 ATF7 ISG15 TRIB3 CEBPB CEBPE NMI JUN BATF EGR1 FOSB FOS ATF3 CEBPA DDIT3 HLF ASNS PMC6534082__F1 The mutIDH1 and mutIDH2 pathways and molecular mechanisms related to oncogenesis ME3 TET2 PLOD1 TET1 PLOD3 PLOD2 HEL-S-26 PMC7507458__F3 Links between lncRNAs and Hippo signalling cascade HK2 S100P PMC8603304__F1 Fungal cell wall components modulate our immune system NLRP3 IL13 TLR4 MTOR TNF IL1B PMC7507458__F2 Links between lncRNAs and Hippo signalling cascade LATS1 RASSF1 PLK4 TUG1 PMC9264363__F7 Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex MAVS ATP13A1 UBL4A BAG6 SGTA PMC7507458__F4 Reciprocal interaction between lncRNAs and Hippo cascade LATS1 LATS2 AMOT USP9X PMC7879558__F1 NHEJ and antiviral innate immunity TBK1 IRF3 IRF7 PMC1705513__F1 Inflammatory pathway in psoriasis CCL27 CD2 TGFA CCL3 CD69 CD34 CD83 NGF CCL19 IGF1 CCL21 CCR6 CCR7 CCL4 VCAM1 CCR10 CCL20 PMC8202900__F7 Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFB1–smad/p38MAPK–lnc865/lnc556–miR-29b-2-5p–STAT3 signal pathway KLF4 STAT3 TGFB1 SMAD2 PMC8807838__F9 Promotion of the inflammatory response in mid colon of complement component 3 knockout mice SLC26A3 NLRP3 HEL-S-62p COX2 CFTR TNF PMC7507458__F1 Molecular schematic of canonical Hippo signalling cascade in cancers LATS1 LATS2 PMC2168916__F7 Regulation of the AHR-XRE pathway by NRF2 KEAP1 AHR CYP1B1 PMC1361361__F7 Shp-1 mediates the anti-proliferative activity of TIMP-2 in human microvascular endothelial cells RECK FGFR1 CDK2 CDK4 PMC7267004__F1 Phagocytic receptors and modulating factors functioning in the phagocytosis as well as the antigen-presenting effect to naïve T cells in teleost phagocytic B cells CD80 BCR TLR9 CD22 PMC10341927__F10 Identification of Moesin (MSN) as a Potential Therapeutic Target for Colorectal Cancer via the Beta-Catenin-RUNX2 Axis HEL70 RUNX2 CTNNB1 PMC6611515__F4 Comparative RNA-seq analysis reveals dys-regulation of major canonical pathways in ERG-inducible LNCaP cell progression model of prostate cancer DBF4 RBL1 CDC45 ORC3 ORC2 CDK4 PMC9005906__F1 Immunomodulation as a Protective Strategy in Chronic Otitis Media ATG16L1 NLRP3 EGFR NOD2 IRF1 DAP NLRP2 NOD1 TNF MYD88 PMC2999475__F8 Summary of metabolomic findings in Hnf1a-null mice PAH HNF1A PMC3819728__F1 Unfolded protein response and its regulation on cell activities ATF4 EIF2A NRF1 PMC11491690__F1 HOXA9/MEIS1 and FBXO22 promotion of KMT2A‐r acute leukemia KMT2A FOXM1 BACH1 HOXA9 MEIS1 CTNNB1 PMC4637163__F3 Immunological Basis in the Pathogenesis and Treatment of Bladder Cancer STAT3 MIF CD163 IL1B PMC7911109__F1 Oxidative stress and antioxidants in the context of non-alcoholic fatty liver disease (NAFLD) TG ATF4 PMC3621409__F5 Evolution of mirrregulation EGF CIC EGFR PMC4637163__F2 Immunological Basis in the Pathogenesis and Treatment of Bladder Cancer STAT3 CCL3 CCL4 CCL2 PMC6172046__F7 Taurine Upregulated Gene 1 signaling circuit in osteosarcoma PIK3CA FOXM1 PI3 TUG1 PMC8898369__F8 TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer CD44 EGFR CCL5 PMC6524718__F4 The Nodal signaling cascade LEFTY2 NODAL GDF1 PITX2 PMC3448918__F8 Proposed mechanism for D10G-mediated suppression of NFKB-regulated gene expression TLR4 TLR5 PMC5951999__F7 Mechanism underlying how BYD exerts a cardioprotective effect BAX HEL-S-101 MAPKAPK2 BCL2 PMC4656338__F2 Signal transduction pathway in HIF-1A regulation PTEN MTOR VHL PMC8750610__F1 Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials STAT3 BAG3 VCP PMC3571113__F1 Six important signaling networks of osteoblast differentiation EPHB4 SOST JUNB APC BMP2 LRP5 ATF4 ARHA DLX5 RUNX2 FGF2 PMC5209547__F1 Quantification of thalamocortical dynamics using natural and artificial paired-pulse paradigm STIM2 STIM1 PMC5564849__F5 Integration of phytochemicals and phytotherapy into cancer precision medicine SFRS18 CTHRC1 POTEH RB1 ERF NDN CPN2 HLTF IDE ELAC2 ZFP36L2 POLM TMEM14A RPF2 RALY ZNF91 RPUSD3 SUGP2 SHE ID1 GTF3C2 CRTAP SKP1 DLD MPP3 MSL2 PMC8692699__F2 Roles of long non-coding RNAs in lung cancer HOXA1 SP1 PDPK1 PHOX2A PMC3925027__F2 Cytokines and their receptors regulating peripheral B-cell survival CD44 SYK PIM2 HGF CD74 BCR TNFRSF13C TNLG7A MIF PMC3130501__F1 Intrinsic and extrinsic apoptotic pathways BAX BAD FADD PMC5803919__F1 Systemic iron homeostasis ERFE BMP6 TFR2 HEPH HAMP HFE PMC4262241__F3 Network enrichment analysis of point mutations in genome TCGA-02-0014 PRKD2 TBK1 EGFR BRCA2 NRAP PIK3R1 MN1 PTEN MAPK9 DST CSF3R NGF PDZD2 HEL-S-26 TNK2 HEL-S-133P USF1 SLC2A2 VAV1 SYNE1 BCL11A TMBIM4 CSMD3 PRKDC PDGFRA MAPK7 NTRK1 MAPK10 PMC11615452__F2 Therapeutic strategies targeting Wnt/Beta-catenin signaling SFRP4 DKK1 WIF1 CTNNB1 PMC3075376__F1 Targeting GSK-3 family members in the heart: A very sharp double-edged sword APC LRP5 MYC CTNNB1 PMC11615452__F1 Wnt signaling pathway CDC42 APC RHO NLK CCND1 DAAM1 CTNNB1 PMC8699097__F1 Therapeutic Targets of KRAS in Colorectal Cancer RASSF1 GRB2 PMC5070770__F8 Fine-Tuning of the Kaposi’s Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway TLE2 LEF1 NOTCH1 PMC5625838__F2A Innate and Adaptive Immune Responses in Chronic HCV infection TBK1 MAVS TRADD TRAF5 IRF3 TRAF3 TRAF6 TRAF2 PMC4799835__F3 TRAF6 in T lymphocyte activation and differentiation SMAD2 FOXP3 MTOR TRAF6 GATA3 TGFBR1 PMC10564417__F7 Schematic diagram showing the proposed mechanisms by which exosomal miR-486-5p derived from M2 macrophages regulates the osteogenic and adipogenic differentiation of BMMSCs SMAD2 SMAD4 RUNX2 PMC7175141__F1 Association between IDH1/2 mutation and NAD Production in Cancer NAPRT NADK DHFR NAMPT PMC10649670__F6 Central illustration CXCR3 THBS1 SPARC VEGFD CCR3 ADAMTS9 ITGB3 CXCL10 CCL2 XBP1 CCL24 ADM2 SCG2 BMP4 IL8RB PMC8072900__F3 Insulin Resistance in MAFLD TG IRS1 PMC7895515__F1 TGFB signaling pathway TGFBR2 SMAD2 SMAD4 ARHA TGFBR1 PMC9490123__F1 DNA damage, inflammation and aging: Insights from mice ATR CGAS ATRIP ATM SSB CPD PMC5751354__F2 Molecular changes driving the Warburg effect PDC PTEN ENO1 HIF1A MTOR PMC5751354__F1 Glucose metabolism in cells HEL-S-162eP PDC PMC8131720__F8 Downregulation of miR-218 by porcine reproductive and respiratory syndrome virus facilitates viral replication via inhibition of type I interferon responses STAT1 IRF9 SOCS3 JAK1 TYK2 PMC8906930__F4 NRF2 in Bone Metabolism – Friend or Foe? RGS12 DCSTAMP CTSK MAFB NFATC1 TRAF6 MYC CALCR PMC4068281__F3 Signaling pathways and transcription factors supporting or affecting the barrier phenotype of CNS-ECs FYN NQO1 NKX2-1 SP3 SHH SOX18 LYN ERG CTNNB1 PMC8906930__F1 NRF2 in Bone Metabolism – Friend or Foe? HMOX1 RBX1 KEAP1 MAL ADA PMC5777696__F1 S1P/S1P5pathway in mitotic regulation SPNS2 SPHK1 PLK1 PMC5466503__F4 Melanocyte differentiation PAX3 TGFBR2 SMAD4 DCT SOX10 SKI LEF1 PMC9344019__F2 Emerging roles of ER-resident selenoproteins in brain physiology and physiopathology SELENOF SELS STT3A SELENOK SELENOM RDH11 SELENON VCP SELENOT PMC7696189__F7 Tyrosine kinase inhibitor (TKI)-based OFF-switch ZAP70 CD19 LCK PMC5466503__F2 Melanocyte activation integrated in the schematic view of the UV-induced pigmentation pathway in the normal skin MC1R HGF SOX9 LIF DCT TYRP1 PMC3227097__F6 Network of core pathways that mediate commitment of cells to the division cycle BAD IKBKB WASL SRC MYC SKP2 SKI PMC7447312__F7 Working model NR1i1 STAT4 PMC6795908__F5 Protein-protein network analysis using the DE genes (log2 fold > 2 and < 2) in the transcriptomic profiles of the cows with PTB-associated lesions versus the control group SLC10A2 MOCS2 SPARC SCOC UGT2B10 ACADM NAGS EREG CENPK PIGK AGL AASDH PTGFR CUBN APOC3 PYGM HEL-S-133P SELE CTH FOS CDYL2 LTB CHST4 HBEGF TAF13 ALG10 HPGD APOB PIGM PTGIR PMC10607693__F5 Fatty acid biosynthesis and TAG assembly pathway reconstruction HMFN0839 FAS DGAT1 GPAT4 GPAT2 DGAT2 ACCS OAS1 PMC7404843__F1 Immune responses and immunotherapy strategy in SARS‐CoV‐2 infection IFNAR2 IFNAR1 ACE2 PMC7922062__F3 Glycan-lectin interactions within the breast cancer microenvironment modulate the phenotype of tumour-associated macrophages CCL24 GAL CXCL5 CD163 PMC2671631__F1 The L-arginine biosynthetic pathway and its association to proline and polyamine biosynthesis NAGS ASL NAGK PMC7827907__F1 Updated Insights on EGFR Signaling Pathways in Glioma NF1 EGFR MTOR SRC PMC8435626__F8 Integrated Phytochemical Analysis Based on UPLC–MS/MS and Network Pharmacology Approaches to Explore the Effect of Odontites vulgaris Moench on Rheumatoid Arthritis SYK APP CCND1 PMC11540160__F1G SOX4 protein in the nucleus of CD31+ HemECs binds to the downstream target gene ESM1, further activating the PI3K/AKT signaling pathway ESM1 MTOR VEGFA SRC SOX4 PMC99857__F9 The B(a)P-induced apoptotic signaling pathway, which is mediated by APIX CDC42 PAK1 RAC1 PMC6037111__F2 Consequences of hepatic fructose metabolism ACLY LPA FAS PMC4667854__F2 Molecular events involving IRFs in immune responses IRF9 TLR9 IRF1 IRF7 IRF4 IRF8 TRAF6 IRAK4 MYD88 STAT1 TLR3 TLR4 IRF2 TLR7 PMC5390468__F2 KEGG TGF-beta signalling pathway ZFYVE16 BAMBI LTBP1 INHA TOB1 FST NOG NOD1 ARHA SKA1 PMC4813201__F1 Relevant intracellular signal transduction pathways of local anesthetic-induced toxicity CDC42 STAT3 BAX JUN BAD APC MYC FOS CTNNB1 FYN SMO MDM2 GRB2 SRC FADD PMC7452060__F1 circSETD3 Contributes to Acquired Resistance to Gefitinib in Non-Small-Cell Lung Cancer by Targeting the miR-520h/ABCG2 Pathway SETD3 ABCG2 PMC6135632__F10 The signaling pathway regulating RAB26-induced SRC degradation (a) Under normal physiological conditions, RAB26 interacts with ATG16L1, resulting in the induction of autophagy, which targets phosphorylated SRC for degradation ATG16L1 SRC RAB26 PMC3886269__F4 Inducible antioxidant defense regulated by Nrf2/Keap1 and the antioxidant response element KEAP1 PRX HEL-S-64p PMC11678013__F2 “Disease-Pathway-Target-Component-Drug” network HPSE FLT3 ALPL ADORA2A TNKS2 MMP12 HEL111 GSK3B PLK4 NPY5R CCNA2 FAAH PLK1 DAO MAPK3 CDK5R1 MAP3K8 KCNA3 CDK6 MME ALK FLT4 ADRA2A PIM3 FGFR1 F10 MMP2 MMP3 NRAS KDR BCHE CA14 ABCB1 MGMT NR1i1 MMP7 NOS2 PIM2 CES2 EIF4H SREBF2 SNCA NTRK2 TNF CHRM2 ADK EDNRA MAP3K7 PTGIR CA4 CA7 PGR FABP1 TERT NR1C2 PRKCH PRKCB SSTR4 CA12 ADAM17 SLC6A3 CNR2 AHR ALOX15 APP TOP2A EPHB4 ACHE HEL-S-72p PTGER2 HSD17B3 CYP17A1 CA13 KIT NR3C1 SLC6A2 VHL NR3C2 RORC PTPRS FABP5 IKBKB ADRA2C HSD17B1 HSD17B2 CFTR ERBB2 PTGES LYN CA9 SELP ADA LCK OGA PPARG AURKA SYK HRH3 EPHA2 TACR2 SOAT2 PTPRC PTPRF CTSG PLA2G2A NLRP3 PRKCA ALOX12 ADORA2B PLA2G7 SRC AXL HK2 SCD METAP2 NAMPT LGALS9 HRAS CDK5 HMGCR NADK AURKB HSD11B2 CDK2 DHCR7 FDFT1 HEL-75 MMP14 EGFR GLRA2 BRAF PTPN13 NOX4 RORA MYLK ALDH2 BTK PRKCE SHBG F2R CYP2C19 INSR SSTR2 NR3A2 F2 F3 SLC29A1 SLC28A3 IL2 ABCG2 CDK4 CDC2 JUN SQLE LGALS7B FABP4 MMP9 PTGS2 PTPN6 FGF2 PARP1 ESRRA TAS2R31 NMUR2 NR1C1 SSTR3 KDM4E IDO1 TNKS PRKDC FBP1 XDH RPS6KA3 MAP2K1 PMC3174208__F1 Comprehensive Association Analysis of Homocysteine Metabolic Pathway Genes in Singaporean Chinese with Ischemic Stroke MTHFD2 TCN2 DHFR CTH MTRR TYMS SLC19A1 HEL-S-51e AMD1 NNMT MTHFD1 FOLR1 PON1 SHMT1 CHDH HEL-S-61p MTR TCN1 MAT1A PMC6545262__F2 The Notch pathway in human and mouse Th2 cell development and function IFNG GATA3 PMC8533628__F16 Inhibition of Membrane-Associated Catalase, Extracellular ROS/RNS Signaling and Aquaporin/H2O2-Mediated Intracellular Glutathione Depletion Cooperate during Apoptosis Induction in the Human Gastric Carcinoma Cell Line MKN-45 LPO PMC4573851__F2 The roles of FANCM family proteins in replication fork repair and crossover control SMC5 FANCM BLM RMI1 PMC4573851__F1 FANCM and partner proteins in coping with template lesions during DNA replication ATR ATRIP FANCM FAAP24 BLM PMC7896717__F3 Gene networks showing signatures of pervasive positive selection in Han Chinese and/or Japanese populations according to signet analysis performed on whole genome distribution of nSL scores and aimed at testing for polygenic adaptation KLF2 GPAM NOX3 PRKCE PRKCZ DGKE ATF2 PLCB3 PMC4114643__F2 Osteoclast differentiation and bone resorption by Rho GTPases CDC42 RHOU SBDS NFATC2 ME2 NFATC1 TRAF6 RAC1 PMC11592687__F3 Oxidative stress activates Hippo signaling pathway LATS1 LATS2 NEDD4 KEAP1 NF2 PMC11592687__F2 Hippo signaling pathway in ROS production LATS1 LATS2 FOXO1 PMC11592687__F1 Core components of the Hippo signaling pathway and their upstream regulators LATS1 LATS2 RHO NF2 PMC4535673__F3 Profiles of central and oxidative stress response metabolism pathways of K HEL60 GPD2 ACO2 ENO1 MDH2 PMC11772995__F6 Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway CORT DCX CRH MTOR BDNF PMC9152203__F3 Plasma proteomics reveals an improved cardio-metabolic profile in patients with type 2 diabetes post-liraglutide treatment KRT10 SERPING1 APOH FGL1 SERPINA3 RBP4 MAP2K1 MAP2 PMC8533628__F13 Inhibition of Membrane-Associated Catalase, Extracellular ROS/RNS Signaling and Aquaporin/H2O2-Mediated Intracellular Glutathione Depletion Cooperate during Apoptosis Induction in the Human Gastric Carcinoma Cell Line MKN-45 LPO TUB PMC4695067__F6 Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2 EGF PMC8155723__F3 Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis STAT1 EBI3 STAT4 JAK1 PMC10376197__F4 TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation TRPM7 TRPM2 SRC PMC10243030__F7 NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway CDH2 HMGCR Nucb2 PMC5618535__F2 PALB2 in the DNA damage repair ATR RAD51 DNA2 BRCA1 BRCA2 ATM PALB2 PMC8961363__F3 Floral Scents and Fruit Aromas: Functions, Compositions, Biosynthesis, and Regulation C6 HEL-S-5 C9 PMC8001967__F3 Mitochondrial regulation of ferroptosis RPL8 LONP1 ACSF2 FXN FH SFXN2 CS PMC2787666__F2 The complex network of protein–protein interactions of Ape1 FANCE PMS1 PNKP CASP9 CHEK1 VEGFA PMC5384343__F2 MTOR signaling pathway RHEB RPS6 TSC2 TSC1 EGFR PTEN DEPTOR IRS1 EIF4E PMC3260548__F1 The signaling cascade in response to the release of dsRNA from LRV particles, production of IFNB and secretion of proinflammatory cytokines and chemokines TLR3 TLR9 IRF3 TLR7 CXCL10 MYD88 PMC8348654__F1 Failure to Guard: Mitochondrial Protein Quality Control in Cancer PMC7828172__F2 ROR1 signaling CDC42 STAT3 HEL113 WNT16 MTOR DOCK2 BMI1 WNT5B BCL2L1 CCNE1 SNAI1 SRC CCNB1 CCND1 ABCB1 CDK4 ROR1 RPS6 JUN ARHA FOS KIF26B RELA HEL-S-69p CASP3 BCL2 DAAM1 PMC6595721__F2 Major mechanisms regulated by SUMOs and SUMOylation in kidney disease BAX SMAD2 RELA SMAD4 PTMS SKI VHL PMC4030106__F1 Roles of IL-21 and IRF4 in immune and metabolic regulation STAT3 FOXO1 IL21R IRF4 FOXP3 PMC2787666__F1 Base excision repair (BER) pathway OGG1 MPG FEN1 PCNA UNG PARP1 PMC7828172__F3 ROR2 signaling CDC2 CDC42 STAT3 RPS6 SNAI2 JUN HEL113 PCNA ROR2 MMP9 MTOR ARHA FOS WNT5B KIF26B CCND2 HEL-S-69p MMP2 SRC DAAM1 PMC4890876__F3 All of animal cells may be intrinsically programmed to self-destruct TRADD BCL2 TNF FADD PMC2667944__F1 Angiotensin converting enzyme 2 in the brain ACE2 PMC11575309__F7 DLL4-targeted CAR-T therapy sensitizes neoadjuvant chemotherapy via eliminating cancer stem cells and reshaping immune microenvironment in HER2+ breast cancer PDIA4 DLL4 ELANE RBPJ MPO PMC3348497__F1 Insulin-like growth factor (IGF)-1 signal transduction IGF1 IGF1R IRS1 PMC7226328__F4 Network analysis by Ingenuity Pathway Analysis (IPA) CXCL12 SFRS3 SMAD2 NR1C2 VEGFA ANKRD22 COL13A1 NPTX1 SFRP4 COL18A1 PCDHY NR3A2 CREBBP EP300 GRIA4 NRXN1 PMC10376197__F3 TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation BAX TRPM2 TRPA1 NFATC2 TRPV1 TRPC3 PMC10376197__F2 TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation TRPM7 TRPM2 ATF4 PMC3926887__F6 Novel antioxidants are not toxic to normal tissues but effectively kill cancer cells MAX ECSIT FAS CD14 NLK BDNF DAO PMC8533075__F10 Salvianolic Acid C Protects against Cisplatin-Induced Acute Kidney Injury through Attenuation of Inflammation, Oxidative Stress and Apoptotic Effects and Activation of the CaMKK–AMPK–Sirt1-Associated Signaling Pathway in Mouse Models BAX TLR4 GPX3 SIRT1 UNK PMC9387421__F3 Zinc delays the progression of lung disease by affecting a variety of signaling pathways BAX BAD MTOR IL1B PMC3652739__F4 Microarray analysis also indicated an increase in Wnt signaling and cell cycle regulation in women PCNA DHFR MYC PMC7226441__F2 Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors CDH2 STAT3 APC HIF1A CXCR4 PMC9428319__F3 Pathomechanisms of bone loss in rheumatoid arthritis TH SOST DKK1 PMC5751940__F1 TumorMap framework and application to the analysis of the TCGA Pan-Cancer-12 Dataset JUN ETS2 PTPRC KIT Nbla10317 NFATC1 HIF1A EGR2 FOS LCK PRKCB PMC4753150__F4 Vitamin D and Calcium Regulation of Epidermal Wound Healing NR1i1 CDC20 TCF4 MED1 AXIN2 SFRP1 CTNNB1 CD44 GPX2 MSX1 SPRR1A MYCBP SOX7 SOX21 WIF1 PMC3582304__F2 Therapeutic targets of the Wnt signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC8706120__F3 Roles of the Virome in Cancer MAP2K6 RAC1 PMC3582304__F1 Diagrammatic representation of the canonical Wnt signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC5568901__F1 Antiviral mechanisms in mammalian cells: IFN-based antiviral system, including IFN expression pathway (AE) and IFN response pathway (AR); the intrinsic antiviral pathway (B); and the RNAi antiviral pathway (C) CGAS TLR3 RNASEL JAK1 TYK2 RAC1 PMC9170969__F1 Antiviral immune response by African swine fever virus (ASFV) IFNG RNF128 IFNGR2 CGAS MAVS TLR3 STAT2 IFNAR2 TLR4 IRF9 IRF3 TYK2 PMC9170969__F3 Antiviral immune response by African swine fever virus (ASFV) BAX TRADD BCL2 ATF4 EIF2A CYLD TRAF2 PMC6338618__F7 Proposed model for the role of inhibition of BCLM by Ponatinib TNC JUN ANGPTL4 PTGS2 PMC8255676__F1 Ferroptosis Holds Novel Promise in Treatment of Cancer Mediated by Non-coding RNAs VIT LOX GLS GPX4 SLC38A1 FACL4 SLC7A11 HEL-S-64p PMC8590218__F4 Gene profiling of Toll-like receptor signalling pathways in neutrophils of patients with acute-on-chronic liver failure CD40 TIRAP TLR3 CD36 PDC CTSK IRF1 IRF3 TRAF3 TRAF6 RAC1 LBP PMC2827926__F3 The refined scheme of the glyoxylate regeneration cycle, now termed ethylmalonyl-CoA pathway (right), and its connection to the serine cycle (left) HPR GCK PMC8093191__F1 miRNAs affect animal behavior related to MDD and BD by regulating the expression of genes involved in serotonergic neurotransmission and signaling pathways activated by glucocorticoids, BDNF, Wnt, and guidance cues FKBP5 DCC SGK1 APC 5HT1A GSK3B PTEN ARHA BDNF STX1A SIRT1 CTNNB1 PMC4335796__F1 NLR-mediated suppression of canonical and non-canonical NFKB signaling CD40 NLRP12 NLRX1 NLRP6 NLRC3 RELB NOD2 IRAK1 TRAF6 MYD88 PMC3312985__F4 Genes identified as part of the significant Para-ICA networks highlighted on a KEGG Alzheimer’s pathway diagram derived from the DAVID functional association tool TES LPL IDE BAD AFP CASP3 PC SNCA HEL-S-11 ATP6 FADD PMC6895177__F8 Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors HMGB1 NLRP3 TXNIP IL1B PMC8387910__F1 Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review NR1C1 ADIPOR1 ADIPOR2 PMC7827308__F8 Simplified representation of intracellular pathways activated upon TLR activation and working mechanism of B18R ADAR TLR3 TLR8 IRF3 IRF7 TLR7 MYD88 PMC8841753__F2 Peptide-Based Vaccines for Tuberculosis TLR1 IL6 CCL2 MYD88 PMC11597542__F2 TLR and RLR signaling pathways and LNP effects IL10 MAVS CXCL1 IL18 TLR9 TLR8 IRF3 TLR7 IL6 TRAF6 MYD88 PMC8136793__F1 Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication DDT RAD51 PRIMPOL PMC5940413__F5 Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer PIK3CA MAP3K1 GRB2 MTOR IRS1 PMC7338517__F6 Spermidine activates RIP1 deubiquitination to inhibit TNF-Alpha-induced NFKB/p65 signaling pathway in osteoarthritis MMP3 IL6 PMC2958230__F1 Effect of TBCD and its Regulatory Interactor Arl2 on Tubulin and Microtubule Integrity TBCE TBCC TBCB TBCA ARL2 TBCD PMC8136793__F3 Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication DDT PCNA PRIMPOL PMC11641610__F3 Key signaling pathways involved in T cell senescence within the tumor microenvironment ZAP70 HLA-G ATM TERT MTOR PMC5195921__F8 G protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis NR1C1 CYP8B1 CD36 CYP7A1 FGF21 CYP7B1 CYP27A1 GHR PMC6704447__F11 Model for Rac1 involvement in TGFB1–driven renal fibrosis EGFR SMAD4 SRC PMC3973904__F1 Cholesterol metabolism, lipid rafts and autism spectrum disorders HMGCR SQLE LDLR CYP46A1 BDNF ABCA1 PMC5411428__F1 Proteostasis network and ALS FIG4 FUS TBK1 VAPB TMEM106B ATF4 XBP1 VCP CHMP2B HEL-S-44 C9orf72 PMC5579367__F1 Live and let die: ZBP1 senses viral and cellular RNAs to trigger necroptosis RIPK3 CGAS ZBP1 MLKL RIPK1 PMC9393224__F3 RNA binding proteins in osteoarthritis ZFP36 FUS GNL3 QK3 SOX9 TLR4 BCL2 YTHDF1 TAF15 FGF18 NCL PMC4772380__F10 HCV induces transforming growth factor B1 through activation of endoplasmic reticulum stress and the unfolded protein response ATF3 ATF4 PMC6523516__F7 Molecular mechanism through which high glucose (HG) concentration promotes proliferation and migration in colorectal cancer (CRC) cells IGF1R CCNB1 SRC PMC5053399__F1 Identification of novel peptoid agonists of fibroblast growth factor receptor using microarray-based screening GRB2 PMC9162355__F10 1,2,3,6-Tetra-O-galoyl-Beta-D-glucose induced apoptosis signalling pathway in SGC7901 cells BAX ATM APAF1 PMC6996149__F4 Major cholesterol metabolic pathways in brain CH25H HSD3B7 CYP46A1 CYP7B1 CYP27A1 PMC6996149__F3 Regulatory factors of the acidic pathway of bile acid synthesis MAFG CYP7B1 CYP27A1 PMC6996149__F2 Acidic pathway of bile acid synthesis in metabolic regulations FAS ABCG8 ABCG5 CYP7B1 PMC6996149__F1 Two major pathways of bile acid synthesis in mammalian liver CYP8B1 CYP7A1 CH25H HSD3B7 CYP46A1 CYP7B1 CYP27A1 PMC8212140__F3 Reactive oxygen species produced by altered tumor metabolism impacts cancer stem cell maintenance CD44 HK2 MYC PMC5789368__F1 Key players in the mammalian autophagy pathway discussed in this review RHEB TSC1 ULK1 TFEB ATG14 PMC3689841__F1 Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation PTEN GRB2 SHE GAB2 PMC6471273__F1 Biosynthetic pathway of ginsenosides according to RB1 IPP MVK PMC11787699__F1 YAP/TAZ in soluble biological signals in bone LPA SMAD1 DKFZp781O1323 SMAD2 SMAD4 RHO PMC5560141__F2 The EGFR signaling pathway involving CEMIP mediation EGF NRG1 CEMIP SRC PMC4825606__F1 Diagram of the roles and its signaling pathway of Cyclin B3 in oocyte meiosis APC CCNB1 CCNB3 PMC8042443__F7 A, schematic diagram showing two separate DGKζ signaling complexes, one for Rac1 activation (left) and one for RhoA activation (right) LPA PAK1 MARCKS ARHA RAC1 PMC6496019__F7 Schematic diagram proposed by the present research ATF4 EIF2A XBP1 PMC2789784__F2 Signaling pathway downstream of PI3K affect cell death and cell survival PI3 PDK2 MTOR PMC2536507__F2 Pathogen recognition systems IRF3 TRAF3 TRAF6 PMC4422111__F4 Kreb's cycle used to determine relative flux rates through acetyl-CoA synthetase (ACS), pyruvate dehydrogenase complex (PDH), pyruvate carboxylase (PC), and glutamate dehydrogenase (GDH) MAL PC CS PMC2330263__F2 Integration of Progesterone Receptor Action with Rapid Signaling Events in Breast Cancer Models GRB2 SRC CCND1 PMC5701508__F1 The crossroads of breast cancer progression: insights into the modulation of major signaling pathways HBEGF SP1 FRK EGFR RELA GPER PMC11747557__F6 Active ingredients of Radix Codonopsis exert anticancer effects in gastric and livercancer BAX PMC4397019__F7 Atypical Protein Kinase C Zeta: Potential Player in Cell Survival and Cell Migration of Ovarian Cancer PRKCA PRKCZ ITGB3 PMC11747557__F5 Active components of Radix Codonopsis promote lung cancer cell death and inhibitinvasion and metastasis CASP9 BAD TRADD TRAF5 GRB2 TRAF2 PMC12023346__F7 The effects of intraamniotic LPS exposure on the TRP metabolic pathways in the placenta and fetal brain TPH1 IDO1 KMO TPH2 IDO2 PMC59539__F2 Schematic model of Shh/Fgf10/Bmp4 signalling during lung branching morphogenesis BMP4 SHH SMO FGF10 FGFR2 PMC59539__F1 The Hh signalling pathway, based on what is known in flies C2 SUFU SMO PMC11000535__F3 STAT3, EMT-TFs, miRNAs and lncRNAs form complex network to regulate EMT STAT3 TWIST1 PMC4846185__F7 ARF1 in mediating gefitinib sensitivity in breast cancer cells AXL ARF1 EGFR SRC PMC8216565__F10 Apoptosis signaling pathway MAPDA CAD CASP2 GEM AIP ATM APP ATF4 AGA FADD PMC12023346__F1 Tryptophan metabolic pathway HEL-S-90n KYNU KMO AANAT HAAO ASMT AFMID DDC PMC7169063__F1 IFN production pathway and different ways that the virus disrupts this pathway TBK1 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC3060584__F6 ‘Integrative Physiology 2.0’: integration of systems biology into physiology and its application to cardiovascular homeostasis AMBP HEL-S-11 MARCO PMC7169063__F2 IFN signaling pathway and different ways that the virus interferes with this pathway STAT2 IRF9 TYK2 PMC5354237__F2 Systemic damage responses of the fat body methionine metabolism (A) Methionine metabolism in Drosophila HEL-S-182mP PMC5675701__F8 Long non-coding RNA CRNDE acts as a ceRNA and promotes glioma malignancy by preventing miR-136-5p-mediated downregulation of Bcl-2 and Wnt2 MTOR PMC3035979__F2 Gene expression profile PLN TNC PMC4406277__F4 Pathway visualization CCND3 ATR TGFB1 MPEG1 SMAD4 SKP2 CCNH PTTG2 RB1 CCNE2 CCND2 PRKDC ATM EP300 PMC3559342__F4 Genome-Wide Pathway Analysis Reveals Different Signaling Pathways between Secreted Lactoferrin and Intracellular Delta-Lactoferrin KLHL20 FGD2 SMN1 HNRPR FIP1L1 NRBP1 HEMGN DHX38 CSTF2 SPIN1 GCDH FOXE3 HLA-DQA1 CLN3 MAST1 HSPB3 PHB2 BARD1 SULT2B1 CTDP1 SIGMAR1 DDX27 AP3D1 NBPF11 KLK10 MBD3 RNPS1 PMC4542009__F1 Tumor Angiogenesis PIGF EGFR NRP1 NRP2 ERBB2 SRC VHL PMC3559342__F3 Genome-Wide Pathway Analysis Reveals Different Signaling Pathways between Secreted Lactoferrin and Intracellular Delta-Lactoferrin PRPF19 SALL4 DNTT TP63 GPR174 FGF6B CRHR2 CD200 RPLP2 AVP PMC3885718__F6 Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK SIRT1 IRS1 PMC4527020__F1 Location and signaling pathways of pattern recognition receptors TLR3 TLR4 MAL TLR9 TLR8 CD14 TLR5 IRF3 IRF7 TLR7 MYD88 PMC8235326__F2 Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma S100A4 TG BAD ORAI1 STIM1 BNIP3 MCU PMC8235326__F1 Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma ORAI1 STIM1 NACA2 MCU SMDT1 PMC4034727__F1 LncRNAs associated with the p53 pathway WRAP53 MDM2 PMC8458797__F1 Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway C6 CD59 HEL-S-62p PMC5701508__F2 PI3K signaling pathway.Notes: (A) Activation of receptor tyrosine kinase (RTK) by a ligand results in phosphorylation of the receptor and adaptor proteins GAL PTEN MDM2 MTOR PMC5701508__F5 Wnt pathways.Notes: (A) Planar cell polarity (PCP) Wnt pathway in “off” state, with no ligand bound to Fzd receptor leads to Beta-catenin proteasome degradation APC RYK RHO PMC5701508__F4 JAK–STAT signaling pathway.Notes: (A) Specific ligands bind to membrane receptors, leading to dimerization, which promotes JAK activation and transphosphorylation, which in turn phosphorylates STAT, prompting its dimerization STAT3 STAT1 IL10 SOCS2 IL6 PMC5981260__F2 Tumor suppressor molecules signaling ATR BRCA1 GSK3B MAF ATM PTEN MDM2 PMC8289457__F6 Pediatric Pulmonary Hypertension: Definitions, Mechanisms, Diagnosis, and Treatment BMPR2 CLIC4 ID2 GSK3B SMAD6 ARHA ID1 RAC1 ID3 CTNNB1 SMURF1 FKBP1A SMURF2 PMC5701508__F8 NFKB pathway.Notes: (A) The canonical pathway starts with binding of TNF to its receptor, activating the IKK complex, which phosphorylates IKBA, promoting its polyubiquitination and further proteasome-dependent degradation LTB LTBR RELB TNF PMC4684398__F6 Nontypeable Haemophilus influenzae-Induced MyD88 Short Expression Is Regulated by Positive IKKB and CREB Pathways and Negative ERK1/2 Pathway IRAK1 IRAK4 MYD88 PMC12111433__F6 This illustration depicts the pathways and key genes involved in the synthesis of chlorophyll and SGAs during the photoinduced greening of potato tubers POR RFWD2 UROD SSR2 PMC11954216__F5 Naturally occurring products that inhibit mTOR in BCSCs ME3 HEL-S-62p PTEN MTOR PMC7968835__F3 Towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe ADRA1A CACNA2D4 LYN PTH1R PMC11954216__F2 The mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials CD44 TSC2 IGF1 SMAD2 SOX2 EMP3 HRG PROCR ST8SIA1 IGF1R SMURF2 PMC11954216__F1 Cellular Mechanisms of mTOR in BCSCs: This schematic illustrates the multifaceted roles of mTOR in regulating cellular functions in BCSCs, with implications in metastasis, metabolism, autophagy, and ferroptosis SOX9 ULK1 ARHA MTOR RAC1 HDAC6 PMC11954216__F3 Targeting the PI3K/Akt/mTOR Pathway in BCSCs with synthetic drugs: This figure depicts synthetic inhibitors targeting the PI3K/Akt/mTOR pathway in BCSCs to reduce survival, proliferation, and resistance EGFR MTOR NOTCH1 PMC3670175__F1 Quantitative proteomics by amino acid labeling identifies novel NHR-49 regulated proteins in C. elegans ACOX1 FAT1 FAT2 PMC9604078__F1 Rationale for Combining the BCL2 Inhibitor Venetoclax with the PI3K Inhibitor Bimiralisib in the Treatment of IDH2- and FLT3-Mutated Acute Myeloid Leukemia BMI1 FLT3 STAT3 TET2 CDKN1A MCL1 BCL2 PTPN11 MDM2 MTOR PMC3186052__F6 Inhibition of prostate cancer cell proliferation through statin use, and its impact on the HMG-CoA pathway RHO RAC1 PMC4731498__F2 Placental mTOR as a nutrient sensing signaling pathway RPS6 IGF1 EIF4E PMC3744028__F9 Summary of the proposed role of Pak1 in mediating stretch-induced CTGF upregulation PAK1 EGFR ARHA RAC1 TGFBR1 PMC11933022__F4 TMAO effect on CKD: Three main pathways are depicted: TMAO activates macrophages by stimulating NLRP3 (NOD-like receptor protein 3) and stimulates T cell differentiation to produce multiple inflammatory factors, such as TNFA, IL-6, etc CRP NLRP3 SMAD4 MTOR TNF PMC8274167__F1 Metabolic regulators of enigmatic inflammasomes in autoimmune diseases and crosstalk with innate immune receptors LTA MAVS AIM2 TRAF6 NLRC4 NLRP1 NAIP NLRX1 GSDMD NLRP6 NLRP3 NLRC3 IL1B PMC9627342__F3 Pathological implications of metabolic reprogramming and its therapeutic potential in medulloblastoma HIF1A MB PMC5809401__F9 Schematic representation demonstrating the mechanism by which silibinin inhibits NSCLC metastasis via the EGFR/LOX signaling pathway EGF LOX EGFR PMC5369987__F4 Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis CREB5 SLC2A4 IRS4 PMC4720882__F1 Alcohol and HIV-related neuroinflammation and cytotoxicity contribute astrocyte cPLA2 activation into the limelight CYP2E1 COX2 TNF IL1B PMC5216465__F8 Four possible pathways (circles) by which CNP could activate CFTR GC CFTR CNP PMC5852597__F1 The Wnt signaling pathway that determines stem cell self-renewal TCF3 RNF43 APC ZNRF3 GPR49 PMC4310010__F1 Alterations in selected pathways in head and neck squamous cell cancers HRAS RB1 PIK3CA CDKN2A FBXW7 KEAP1 EGFR TP63 NFE2L2 PTEN CCND1 PMC4704690__F1 Controlling the burn and fueling the fire - defining the role for the alarmin IL-33 in alloimmunity IFNG IL33 AREG PMC5303602__F6 Schematic describing the effects and proposed response on TLR4 signaling pathway and inflammatory cytokines resulting from resveratrol treatment and HFD TLR4 CD14 TRAF6 IL1B PMC5369987__F5 Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis PLN CAV3 CAV2 PDE3B BCR INSR MCU NPY INS PMC3597666__F5 Representation of the top canonical pathway ‘interferon signalling’ detected when simultaneously analysing the mRNA and miRNA data sets with IPA IFNG BAX STAT1 PSMB8 IRF9 IFITM1 PIAS1 IRF1 JAK1 PMC6392285__F8 Calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation NLRP3 TNF IL1B PMC8293156__F2 Cellular Effects of Rhynchophylline and Relevance to Sleep Regulation BAX AMPH GRIN2B CASP9 GSK3B EPHA4 MYD88 TSC2 TSC1 FYN NONO C2 CASP3 HEL-S-11 BDNF PMC8226128__F3 Inflammasomes and Fibrosis HMGB1 NLRP3 KEAP1 TXNIP PMC4333878__F1 Apoptotic cell death pathways and (b) inhibition of the apoptosis signalling pathway STAT3 BAX STAT1 FAS FOXO1 PMC9334798__F1 Mechanisms of Ferroptosis and the Applications in Tumor Treatment: Enemies or Friends? SLC3A2 GPX4 LPCAT3 FACL4 PTEN SLC7A11 DHODH POR ATF3 TSC2 HILPDA NF2 GLS2 PMC4394621__F7 Kinase targets and inhibitors TRADD EGFR PTEN GRB2 MTOR TRAF2 PMC8237755__F2 WIP, YAP/TAZ and Actin Connections Orchestrate Development and Transformation in the Central Nervous System EIF4B RICTOR IGF1 SRC IRS1 PMC8237755__F1 WIP, YAP/TAZ and Actin Connections Orchestrate Development and Transformation in the Central Nervous System EGF GAL RICTOR GRB2 SRC MYC CCND1 PMC7281461__F2 Primary pancreatic cancer recruits fibroblasts to become cancer associated fibroblasts (CAFs) DKK3 ANXA6 FAP HEL-S-70p PMC6460433__F7 Model for regulation of antiviral innate immunity by BA metabolism SLCO2B1 IRF3 SRC CYP27A1 PMC4935551__F2 Role of chaperone-mediated autophagy in metabolism APOC1 FH HEL-S-53e CS HEL-S-30 GPD2 DGAT2 FBP1 HEL-S-32 ADFP HEL-S-61p APOOL HEL-S-26 PMC8343065__F1 Cell Cycle Commitment and the Origins of Cell Cycle Variability CDK6 CDK2 MYC CDK4 PMC7602737__F5 Suggested mechanisms of action of fenugreek on milk synthesis and secretion LPL OXT OXTR IGF1 INSR LYZG ACADS FASN MTOR GHR CPT1A CSN2 PMC5288595__F5 Serum markers that change in response to treatment CNTF NCAM1 RETN CD36 IGFBP1 SERPINA1 IGFBP2 IFNA2 TNF NR3C1 PMC8954493__F7 Gene Expression over Time during Cell Transformation Due to Non-Genotoxic Carcinogen Treatment of Bhas 42 Cells MTHFD2 DHFR SQLE TYMS IPP MTHFD1 ACAT2 PHGDH SHMT1 MVD PSAT1 IDI1 FDFT1 PSPH PMC8795407__F1 The Hippo pathway signalling cascade and its stimuli LATS1 MOB1A MOBKL1A LATS2 TEAD2 TEAD3 BMP4 NF2 VGLL4 TEAD4 PMC5288595__F2 Steroid-specific protein markers SPARCL1 C1R APOE TGFBR3 IBSP AFM TNF INS NR3C1 FGF2 GCG BIRC5 MFGE8 DIPLA1 RTN4 APOB GHR PMC3317229__F4 P38 signalling cascade (adapted from http://www.sabiosciences.com/) MAX JUND OSM JUNB MAPKAPK2 MAPKAPK3 CD14 SRC PMC3317229__F3 JNK signalling pathway (adapted from http://www.sabiosciences.com/) CDC42 GRB2 RAC1 PMC5430417__F6 Mechanisms involved in the antagonist effect of sinapic acid against UVA-induced attenuation of stemness and differentiation properties of stem cells KLF2 CEBPA MIF PMC11592827__F6 Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study CDC42 HEL-S-22 EGFR JAK3 GSK3B STAT1 INSR RARB PDPK1 NR3A2 NQO1 FGFR1 MMP2 MMP3 IL2 MDM2 SRC NR1i1 NR1H3 ERBB4 FABP4 MMP9 APOA2 GSTM1 FABP5 RXRA CASP3 GRB2 PMC7961376__F1 Molecular pathways of novel emerging targets in NSCLC and agents in clinical development PSPN HGF GDNF ARTN NRTN NTRK2 NTRK3 PTEN MTOR RHO KRAS NGF CDK6 NTRK1 RET CDK4 PMC8674491__F3 Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment TG FAS HEL-S-133P CSK AHR MTOR TNF LCK PMC9052532__F3 Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies IFNG TH PNP PMC11953061__F3 Protein–protein interaction (PPI) networks of reproducible and differentially expressed proteins (RDEPs) were generated via the STRING database TUBA1A BAX PPARG HEL113 PCNA CYCS MTOR PTPN6 PRKAA1 PARP1 CDKN1A RELA MMP2 CXCR4 SYT1 CCND1 PMC5458753__F1 ZIKV genome structure and signaling transductions underlying ZIKV infection TYRO3 AXL TLR3 STAT2 MTOR PMC8052633__F3 Interplay between p62-mediated autophagy and the cGAS-STING-mediated DNA sensing pathway TBK1 CGAS ULK1 ATM IRF3 MTOR PMC7026265__F4 Pharmacological strategies to control endoplasmic reticulum (ER) stress in diseases CNPY2 ATF4 EIF2A XBP1 PMC7053098__F5 Cisplatin-induced P53 signaling pathway genes are differentially expressed between Sirt2-deficient and Sirt2-proficient cells RFWD2 CASP9 TSC2 ATR SIAH1 CASP3 CDK2 ATM PTEN MYC UST PMC7096376__F2 NAD biosynthetic pathways NRK NAPRT HEL-S-90n NAMPT PMC7096376__F1 Intra/extra NAD interconnections and NAD-metabolizing enzymes NAMPT ENPP1 PMC7026265__F1 Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities CNPY2 ATF4 EIF2A XBP1 TRAF2 PMC4843516__F2 Neuroendocrine pathways regulate stress tolerance in C NCR1 NCR2 SGK1 PMC8052633__F2 Interplay between autophagy and DDR RAD51 BRCA1 RNF168 ULK1 BNIP3 BCL2 ATM MTOR PARP1 PMC9163742__F3 Prospective Application of Melatonin in Treating Epigenetic Dysfunctional Diseases TGFBI ARID2 PMC8859442__F2 Understanding Reactive Oxygen Species in Bone Regeneration: A Glance at Potential Therapeutics and Bioengineering Applications MSC NOX4 PMC8192769__F5 Schematic diagram of the effects of fadraciclib at 4 h HTRA2 CDC2 BAX BAD DIABLO PMC8001868__F5 Summary of some of the effects of allicin on eukaryotic cells KEAP1 YAP1 IMPACT PMC10343400__F6 Glycosides and UC-related receptors AND transcriptional regulation NLRP3 TLR4 NQO1 PMC8453895__F3 Contribution of irisin pathway in protective effects of mandarin juice (Citrus reticulata Blanco) on metabolic syndrome in rats fed with high fat diet PPARG FNDC5 UCP1 PMC5894358__F11 The schematic diagram of potential molecular mechanisms of anti-inflammation effects of recombinant human Netrin-1 (rh-NTN-1) through UNC5B/PPARG/NFKB signaling pathway after SAH NTN1 UNC5B MPO PMC6746704__F8 Elevated FAM83A expression in pancreatic cancers is driven by a MEK/ERK-JUNB-driven feed-forward signalling loop FAM83A EGR1 FOSB JUNB KRAS PMC134648__F8 Role of Axin2 in Wnt signal transduction APC GSK3B TEF AXIN2 CTNNB1 PMC2860204__F4 Integrin signalling at focal adhesions CRK FYN GRB2 SRC GAB2 PMC9603070__F10 Melatonin Enhances Drought Tolerance in Rice Seedlings by Modulating Antioxidant Systems, Osmoregulation, and Corresponding Gene Expression LOX ASMT PMC4221543__F1 The MAPK/ERK pathway PI3 EGFR MTOR SRC PMC8750957__F2 TNF-Induced Osteoclast Differentiation RELA RELB TRAF3 TRAF6 TRAF2 PMC8307807__F3 Wnt Signaling by FOX Transcription Factors in Cancer FOXM1 FOXO3A FOXB2 CTNNB1 PMC3038089__F2 Biological consequences of methylation on Rho-RhoGDI interaction ICMT RHO OTP PMC3382540__F1 ERK signaling pathway controls T-cell activation and anergy ZAP70 PMC8307807__F1 Wnt Signaling by FOX Transcription Factors in Cancer LRP5 LRP6 CTNNB1 PMC6292965__F9 DT-13 promoted mitochondrial apoptosis and inhibited metastasis via suppressing PI3K/Akt pathway BAX CASP9 BAD CASP3 PMC3170456__F1 Autophagy in Cancer: Therapeutic Implications LAMP2 ATG10 MLST8 TSC2 ATG3 TSC1 ATG12 PML BCL2 PTEN MTOR ATG5 PMC4333878__F2 EBV interaction with the Bcl family CD40 CD74 PMC7665122__F2 Signaling pathway induced by aPL TF TLR4 TRAF6 MYD88 PMC9686959__F2 Ferroptosis and Its Potential Role in Glioma: From Molecular Mechanisms to Therapeutic Opportunities SLC3A2 GPX4 LPCAT3 FACL4 PMC9542548__F5 Mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo TES ERFE FTL EPO HAMP ALAS2 PMC3187864__F6 Axon viability depends on coordinated endocytic trafficking and signaling KIF3A NGF RILP PMC3491533__F8 Diagrammatic presentation shows how Notch and TGFB signaling pathway involved at each pathogenic stage of HBV infection FOXP3 PMC8036441__F5 Quercetin apoptotic mechanism via death ligand and mitochondrial membrane BAX BAD COX2 PMC6323527__F2 Variety of factors control Tn cell survival and metabolic pathway engagement after T cell activation PPARG FAS PARG HEL-S-62p GCLC SLC7A11 HEL-S-51e CPT1A PMC6323527__F1 Core metabolic pathways for T cell survival, activation, differentiation, and function C2 SRC CPT1A PMC5757446__F2 Current and proposed molecular mechanisms augmenting myogenic reactivity in subarachnoid hemorrhage SPHK1 CFTR ARHA TNF SPP1 PMC3893574__F1 MiRNAs involved in the regulation of the IGF-1/Akt pathway and myostatin signaling IGF1 PTEN IGF1R MTOR IRS1 PMC4067963__F10 Model of Sox9, Sox10 and FGF function during lacrimal gland branching morphogenesis SOX9 COL9A1 SOX10 FGF10 COL2A1 FGFR2 PMC11743681__F1 Cellular and Molecular mechanisms regulating Neural Crest (NC) cell migration and polarity CDC42 TRIO CNN2 PTK7 ARHA CXCR4 RAC1 PMC8925056__F8 TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes SDHA CCL22 TSLP PINK1 CXCL10 CCL1 PMC3547893__F1 Interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility ADRBK1 SP1 FPR1 HDAC6 PMC7363821__F1 High temperature- and cortisol-induced changes in gene expression NR1C1 UCP1 PLTP ME1 PMC5550896__F1 TGFB family member signaling and its target in CRC TGFBR2 BMPR2 ACVR2B SMAD1 ACVR2A DKFZp781O1323 ACVR1B BMPR1A ACVR1C TGFBR1 PMC3710993__F1 Energy status of cells modulating cell signaling and mitochondrial function RHEB TSC1 GSK3B PTEN PMC8584016__F1 Systemic Review: Ozone: A Potential New Chemotherapy KEAP1 NQO1 PMC3141289__F1 Signaling pathway leading to signal transducer and activator of transcription (STAT)-3 activation (see text for definitions of abbreviations) STAT3 CNTF EGF TGFA EGFR PMC2646065__F8 Proposed model involving GSK-3 inhibition and the mTOR pathway to stimulate human Beta-cell growth and proliferation RHEB TSC1 IGF1 MTOR IRS1 CTNNB1 EIF4E PMC3923157__F2 Tumor necrosis factorA and its osteoblastogenesis paradoxical effects SOST CERK LRP5 LRP6 RUNX2 PMC8602361__F1 Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease NLRP3 TLR4 PMC2819219__F7 Caspase Mediated Cleavage, IAP Binding and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NFKB Signaling DAP FADD PMC7886986__F1 Major immune cell checkpoints and associated signaling pathways ZAP70 CD48 CD80 APC TRAF5 BTLA TRAF6 TRAF2 LAG3 PMC7963908__F9 TNBS-induced activation of the toll-like receptor (TLR) 4 signal transduction signaling cascade, which leads to the activation of canonical NF-kB pathway IL16 TLR4 TNF PMC8316766__F1 Genetic Polymorphisms Associated With the Pharmacokinetics, Pharmacodynamics and Adverse Effects of Olanzapine, Aripiprazole and Risperidone CYP1A2 UGT1A4 UGT2B10 CYP2C8 ABCB1 PMC5727528__F3 Metabolic interventions predicted by the OptForce algorithm RPE IPP RLIM PMC5319818__F1 Gasotransmitters in cancer: from pathophysiology to experimental therapy TIMP1 COX2 HIF1A FGF2 PMC2572128__F1 Simplified model of translation initiation EIF4B EIF4H EIF5 EIF5B ELF5 EFS ELF3 EIF4E PMC8015171__F9 Basal cell-fibroblast interaction in IPF LPA ACTA2 COL1A1 TGFB1 EDN1 PMC7247570__F3 Cross-talk of the mitogen-activated protein kinase (MAPK)/ERK signaling pathway and mechanism of cell death induction through the ERK-Hippo interplay EGFR MCL1 GSK3B CASP3 BCL2 PMC6435939__F1 Proposed platelet-endothelial cell adhesion molecule-1 (PECAM1) and Src signaling pathway activation in ARDS and in ventilator-induced lung injury STAT3 SRC PECAM1 PMC8467684__F6 Identification and Characterization of Novel circRNAs Involved in Muscle Growth of Blunt Snout Bream (Megalobrama amblycephala) RHEB CASP9 TSC2 BAD TSC1 EGFR CASP3 PIK3R1 PTEN AIRE APIP MTOR PMC7289300__F5 LncRNA-mRNA expression correlation network (co-expression network) analysis of core mRNAs and their correlated lncRNAs SNRPD2 PRSS22 AIP MYC DUSP14 MAGED2 PMC12063130__F2 Targets of JNK/p38 MAPK signaling pathway in OC drug resistance CDC2 CCNB1 TNF CCND1 ABCB1 CDK4 PMC7073664__F7 Putative fatty acid synthase pathway of Thraustochytriidae sp TH FAS tmp_locus_29 CP PMC3328211__F2 Arterial-venous and lymphatic specification in vertebrate embryo SOX17 EPHB4 HEY2 FOXC2 NRP1 FOXC1 NRP2 SOX18 SOX7 PMC3740204__F2 Angiogenesis pathway of FAK, EZH2 and Dll4/Notch in cancer-associated endothelial cells E2F3 VASH1 EZH2 VEGFA SRC NOTCH1 PMC7697807__F1 Activation and negative regulation of NFKB and STAT3 STAT3 IL6 TNF PMC12133565__F6 Loss of Hdac1 hyperactivates oncogenic transcription NOS2 TNK2 CAMK1G CACNA1C JDP2 ALK PDE1C PLCL1 ADCY1 VEGFA PMC3941008__F1 Complement activation pathways FH HEL-S-62p C2 PMC9485881__F3 Advances in the superhydrophilicity-modified titanium surfaces with antibacterial and pro-osteogenesis properties: A review TH CD84 CD163 IL1B PMC3832913__F3 Alternative pathway C6 CD59 CFI CFH C9 THBD CS PMC8139965__F7 Hypothetical schema of the effect of IL-26 on EGFR-TKI resistance ATF3 EGF EGFR DDIT3 CXCL2 EPHA3 ATF4 PMC4670900__F4 The proposed pathway for energy production, based on the KEGG-associated proteins found in the proteome of L SDHA HPR HEL-S-162eP PTS PMC4606066__F1 Expression and function of the insulin/IGF system in normal and colorectal cancer cells IGF2R IGF1 GSK3B MTOR IGF2 IRS1 CTNNB1 PMC6567810__F7 Construction of a regulatory network for integrated miRNA-target genes NR2C2 ZNF609 STAT3 NR3C2 CREB3L2 RFX3 ZKSCAN1 SP1 TET1 PPARGC1A NCOA1 TGFBR1 PMC8324686__F2 Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD) PCSK9 LDLR PMC9437888__F2 Developing a CRISPR‐assisted base‐editing system for genome engineering of Pseudomonas chlororaphis HPD GCG TG PMC9204280__F10 FOXP4-AS1 May be a Potential Prognostic Biomarker in Human Cancers: A Meta−Analysis and Bioinformatics Analysis RPP40 RFC4 SUV39H2 DSCC1 C7orf11 WDR43 PDCD2L FBL BRIX1 MTIF2 PPIL1 CENPV CCDC86 SNRPC RCCD1 SKP2 CPSF3 NPM1 SRPK1 NPM3 GINS1 LSM2 MIS18A ATAD2 TRIP13 CAD EEF1E1 DKC1 CENPN RPF2 HEL-S-70p MDC1 LRPPRC GMNN CDC123 PAICS BYSL MCM7 POLA1 CDC45 RUVBL1 SSRP1 GINS2 LSM7 RFC3 PFAS PSMG1 PMC8324686__F1 Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD) NPC2 VPS35 RAB24 RAB8A NPC1 LDLR RNF26 PMC4128878__F1 Alpha-catenin APC CTNNB1 PMC11898721__F11 QSAR-Based Drug Repurposing and RNA-Seq Metabolic Networks Highlight Treatment Opportunities for Hepatocellular Carcinoma Through Pyrimidine Starvation CTPS2 CTPS1 DTYMK CMPK1 CMPK2 DUT TYMS ENTPD1 ENTPD8 DHODH PMC7404279__F4 Depiction of a cancer cell motility and migration signaling network model that includes DEGs identified by RNA-seq analysis () as displaying upregulated genes in H CDC42 RHO GRB2 SRC PMC11024251__F2 Signaling pathway of EGF EGF CBL EGFR GRB2 PMC9020058__F7 De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet KRT20 CDC20 WNT3A DUSP9 SFN IBSP TERT GABBR2 PLK1 ITGAV CTNNB1 CTNNA2 BIRC5 ITGA2 MAPK12 SRC PPP2R2C CACNA1C GNG4 SOX2 KCNK9 GPC3 SPP1 COL2A1 PTTG1 KRT12 PLCB1 THBS4 PMC7738817__F5 miR-133a involves in EGFR/c-Myc/P53 axis and the associated signaling pathway CXCL12 EGFR ARHA CXCR4 PMC9248048__F3 Footprint of Kynurenine Pathway in Cardiovascular Diseases HMGCR CXCL1 AHR APOB PMC2661541__F1 Transforming growth factor-beta (TGFB) signaling pathway SMAD2 SMAD4 PMC8064165__F8 Dual activation of Hedgehog and Wnt/Beta-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer SUFU LRP5 LRP6 SMO CTNNB1 PMC3236571__F7 Resistance mechanisms in the TRAIL signaling pathway BAX BCL2 FADD PMC3917155__F4 Inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to AMPK activation and anti-tumor activity APRT GIN1 MTOR PMC7670868__F1 Outline of major DNA DSB repair pathway and its relationship with host anti-tumor immune response CDC2 ATR IRF1 CDK2 ATM CHKA PMC11020452__F4 Regulatory mechanism of tsRNAs in cancers TF TSC2 TSC1 FOXK1 APC JAG2 PTEN EEF1A1 MDM2 CTNNB1 PMC4693238__F3 Intracellular detection of viral RNA by PRRs and activation of the innate immune response TBK1 ADAR MAVS TLR3 IRF9 IRF3 IRF7 TLR7 IL1B MYD88 PMC11000312__F3 Mechanisms underlying SALL4 regulation and function in colorectal cancer SALL4 CTNNB1 PMC6814794__F9 KEGG pathway enrichment analysis of methylated regions– CSA2 JUN MMP14 FAS TRADD SELE ITCH MLKL PTGS2 IL6 TRAF3 TNF FOS CA12 CASP3 AGL TRAF2 FADD PMC11000312__F2 Mechanisms underlying SALL4 regulation and function in gastric cancer CD44 STAT3 TGFBI SALL4 HK2 GC EZH2 CTNNB1 PMC9508095__F9 Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin A7 is counteracted by TBK1-p62 axis-mediated autophagy TBK1 IRF3 TRAF3 PMC11000312__F1 Mechanisms underlying SALL4 regulation and function in esophageal cancer MAML1 SALL4 WNT3A NRBP1 SOX2 MEIS1 NOTCH2 NOTCH3 NOTCH1 CTNNB1 PMC3607645__F5 Epidermis model pathways WNK1 OSR1 PMC11000312__F4 Mechanisms underlying SALL4 regulation and function in liver cancer CD44 EPCAM SALL4 PTEN TNF KRT19 PMC5406704__F1 The phosphatidylinositol-3-kinase (PI3K) pathway BAX PTEN MTOR CXCR4 PMC4053166__F1 Meet the terminator: the phosphatase PP2A puts brakes on IRF-3 activation BAX TBK1 IRF3 HDAC6 PMC4891110__F8 Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate tal-1 ENO2 FBP1 ENO1 PCK1 PMC8217088__F6 Lipid metabolic alterations induced by EPHB2 deficiency in prostate cancer EPHB2 DGAT1 DGAT2 PMC6689672__F3 Differential pathway regulation in advanced idiopathic pulmonary fibrosis (IPF) lung TH CXCR3 CXCL13 FUT4 CXCL16 CD14 GATA3 ITGAM CDA CD33 CXCR5 AHR CXCR4 CCL20 PMC4187736__F11 Model recapitulating the role played by HUWE1 in regulating Shoc2-supported ERK1/2 activity EGF SHOC2 HUWE1 PMC3896945__F1 Pharmacological approaches to restore mitochondrial function TFAM NR1C1 NCOR1 RXRA NAMPT MTOR NRF1 PMC8983858__F2 Induction of Endothelial Autophagy and Its Role in the Development of Atherosclerosis VWF KLF2 HEL-S-11 RHO MTOR PECAM1 PMC8642070__F4 Bicuspid Aortic Valve: Genetic and Clinical Insights JARID2 SMARCA4 PMC9202500__F6 Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses IFNK TBK1 MAVS IRF9 EGFR IFNAR1 NOD2 IRF3 TRAF3 KPNA1 PMC5187897__F1 Intrinsic and extrinsic apoptosis pathways in mammalian cells FAS TRADD APAF1 FADD PMC9202500__F5 Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses BAX ATF4 XBP1 PMC9202500__F4 Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses ULK1 IGF1R MTOR ATG5 PMC4614139__F1 Mutations in PI3K, PTEN and AKT have dual effects on neuronal development leading to the formation of HMEG and FCD RHEB TSC2 TSC1 PTEN PMC5447936__F2 AUTS2-Rac signaling pathways in neuronal migration and neuritogenesis AUTS2 ELMO2 RAC1 CP PMC4022194__F2 Signalling pathways that were altered in the high serum group AURKA DLGAP5 SPC25 CDC20 APC KNTC2 E2F7 RPRM POLE SLK PMC9267958__F5 Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways EGF TLR4 GRB2 PMC9267958__F4 Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways TLR4 IL6 MYD88 PMC9267958__F3 Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways IFNG STAT3 STAT1 SRC PMC11654293__F8 Expression levels of differentially expressed genes related to galactose, starch and sucrose metabolism LYZG TREH GLA MGAM PMC6742699__F2 Complement-platelet interactions that can facilitate an inflammatory response that favors atheroma formation VWF FH HEL-S-62p C4A CP PF4 PMC4062840__F2 Regulation of Akt phosphorylation PHLPP1 PHLPP2 PTEN PMC11050257__F3 Representation of the diversity of the AP-1 family of TF CDC42 BATF PAK1 JUNB ATF2 GRB2 MEF2C PMC9375713__F2 NLRP12 in Innate Immunity and Inflammation MAVS IRAK1 IRF3 TRAF3 TNF TRAF6 MYD88 NLRP12 TRIM25 TLR3 TLR4 TLR7 IL1B PMC9556725__F1 Neurobiology of pain and facial movements in rodents: Clinical applications and current research ACCN3 TRPV1 BDNF PMC11050257__F5 MYC protein and its signaling pathway MAX APC GSK3B MYC PMC7390965__F1 Differences between the UPR in mammalian and plant cells EIF2A XBP1 PMC3136489__F7 Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood IFITM2 IFI6 STAT2 PSMB8 IFNA10 IFIT1 IFI30 IFITM1 IFIH1 IRF1 IL6 GBP1 ISG20 IFNG STAT1 PIAS1 MX2 MX1 STAT4 ISG15 GBP2 PMC11050257__F2 Androgen receptor structure and signaling pathway in PCa TMPRSS2 SHBG TBP PMC10570508__F2 PITX1 acts as a core gene that regulates the p53 signaling pathway SF1 TFDP1 PITX1 PIN1 PMC8224422__F2 Synthetic Formatotrophs for One‐Carbon Biorefinery GAL LTA HAL F2 GPT PMC9065266__F3 Inflammasomes in Cancer Progression and Anti-Tumor Immunity NLRC4 IFNG FAS GSDMD NLRP6 NLRP3 GSDMC AIM2 TNF PMC3294376__F4 O-linked N-acetylglucosamine (O-GlcNAc) is a nutrient sensor and underlies glucose toxicity OGA OGT SP1 PLCB1 CRTC2 INS IRS1 PMC9065266__F2 Inflammasomes in Cancer Progression and Anti-Tumor Immunity NLRC4 NLRP1 TSLP NLRP6 NLRP3 AIM2 SI IL8RB PMC9065266__F1 Inflammasomes in Cancer Progression and Anti-Tumor Immunity AIM2 NLRP9 IRF3 NLRP2 LBR MYD88 NLRC4 NLRP1 NAIP NLRP12 GSDMD NLRP7 NLRP6 NLRP3 IL1B PMC5594744__F3 The MUST complex (MAGEL2-USP7-TRIM27) is important for the retromer-mediated endosomal protein recycling pathway VPS35 PMC4020352__F1 Noncanonical transforming growth factor B signaling in scleroderma fibrosis SMAD1 SMAD2 SRC CTGF PMC4020352__F3 Noncanonical transforming growth factor B signaling in scleroderma fibrosis SMAD2 SMAD4 PTEN PMC9243368__F1 Advancements in prevention and intervention of sensorineural hearing loss ATOH1 GSK3B JAG2 HES1 CTNNB1 HES5 PMC3671705__F1 Targeted therapies for head and neck cancer EGFR IGF1R MTOR PMC10224264__F3 Hypothesized mechanism of coronavirus-induced neuronal damage via oxidative stress and mitochondria dysfunction TMPRSS2 ACE2 IL1B PMC11922887__F1 Potential mechanisms of HDAC1 and HDAC2 in microglial activation and/or neuropathic pain HDAC3 HDAC1 TNC SP1 TLR4 HDAC2 MYD88 PMC5960217__F1 Schematic depiction of the canonical and non-canonical Wnt pathways CDC42 WNT3A APC WNT1 RYK ARHA CTNNB1 PMC4340386__F1 Simplified diagram of the sphingolipid biosynthesis pathway in S SIM1 SIM2 HEL-S-5 ORM1 PMC5979467__F2 Role of survivin in caspase-mediated apoptosis BAD FAS CS DIABLO FADD PMC5979467__F3 Survivin regulation EGFR IGF1R CS MDM2 MTOR CTNNB1 PMC5405063__F1 Regulation of translation initiation by the (TOR) pathway, eIF4E activity and eIF2A phosphorylation in response to developmental and environmental cues in plants GCN1 CD2 EIF3S3 EIF2A EIF4E PMC12180219__S1 Bionic bearing-inspired lubricating microspheres characterized by immunomodulatory for osteoarthritis treatment ACAN ADAMTS4 SOX9 PLG MMP3 MMP9 TNF PMC3814599__F1 The nuclear pore complex (NPC) and classical nuclear import pathway NUP133 NUP155 NUP85 RAN NUP107 NUP214 RANBP1 NUP160 NUP62 TPR NUP153 NUP210 NUP98 PMC8143540__F2 Oxidative Stress in Cancer Cell Metabolism BAX BAD PTEN HIF1A MTOR SRC PMC11922887__F3 Potential mechanisms of Sirt1 in microglial activation and/or neuropathic pain HMGB1 NLRP3 TLR4 SHH ARC SIRT1 MYD88 PMC8291349__F4 Regulation of the CYP7A1 gene NR1i1 HGF MAFG TNF FGF8A PROX1 NR2A1 CYP7A1 RXRA FGFR4 DKFZp666G145 SIRT1 IL1B PMC11922887__F2 Potential mechanisms of HDAC3 in microglial activation and/or neuropathic pain HDAC3 TET2 STAT1 CGAS LRRK2 AIM2 SIRT1 PMC10224264__F5 Anti-apoptotic and anti-inflammatory effects of Ginkgo biloba extract (EGb) and its constituents STAT3 STAT1 CDK5 GSK3B PMC8291349__F1 Bile acid and oxysterol synthesis in the liver and other tissues CYP8B1 BAAT CYP7A1 GCA CYP46A1 CYP7B1 CYP3A4 CYP27A1 PMC7538629__F5 Changes of FAs metabolism in hamster liver of HFD group (A) and HFD+ADT group (B) FAS CD36 MFN1 FADS2 FADS1 PMC6514289__F1 Metabolic pathway of vicagrel and clopidogrel in humans CYP1A2 AADAC CYP2B6 CES2 CYP2C19 CYP2C9 PMC8143540__F3 Oxidative Stress in Cancer Cell Metabolism BAX BAD TRAF2 FADD PMC4261550__F1 Neuroprotective functions of resveratrol in AD pathogenesis STAT3 BAX STAT1 GPX1 NOX4 PMC4951507__F4 ICL repair FANCD2 ATR RAD51 BRCA1 BRCA2 FANCM UHRF1 SLX4 PMC10994423__F5 Advances in the application of traditional Chinese medicine during the COVID-19 recovery period: A review STAT1 TAB3 RIPK1 GRB2 ELK3 TRAF2 PMC4951507__F3 Main posttranslational modification events involved in the activation of response to ICLs FANCD2 ATR RNF4 USP1 PIAS1 ATM SENP6 FANCL UBE2T PMC6523687__F1 Epidermal growth factor receptor (EGFR)/EGFR variant III (EGFRvIII)-dependent biological signaling pathways EGFR PTEN MTOR PMC7346972__F1 Insulin growth factor pathway and its relationship to intracellular signaling molecules BAD IGF1R MTOR PMC6376270__F5 Interleukin‐1B (IL‐1B) was up‐regulated in nerve regeneration CD40 SYK EGF LTA TRADD TIRAP LAT MYD88 NGF BTK COX2 BCR TLR4 PTS GADD45B ATM IL1B TNFRSF11A CD14 BLNK CXCL2 PTGS2 LTB TRIM25 LYN LBP BIK LCK PMC5960217__F3 Wnt signaling in hematopoietic stem cells and early B cell development CD24 FZD9 PREB PMC7348145__F8 WDFY3‐AS2 contributes to the suppression of cell proliferation and invasion by manipulating miR‐2355‐5p/SOCS2 signalling axis SOCS2 PMC5960217__F4 Wnt signaling pathway and multiple myeloma CD44 WNT16 IGF1 DKK1 WNT4 IL6 CTNNB1 PMC2694829__F6 HIV-1 TAT T cell receptor signaling pathway LAT HEL-S-11 PMC9300700__F4 Broad view of the role of Galectin-3 in microglia-associated neurodegenerative diseases TREM2 CLEC7A NLRP3 TLR4 APOE GPNMB CD68 MERTK PMC4990112__F3 RNF8 and RNF168 promote the accumulation of 53BP1 and RAP80 at DSB sites UBC ABRA L3MBTL1 BRCA1 RNF168 H2AX RNF8 PMC7687355__F4 Predicted activation of VEGF signaling after both APAP300 and PHX GMNN HOPX FKBP5 ANGPTL4 HMMR AURKB ACKR3 MCM6 ADGRF5 CYP4A11 MAD2L1 PMC4990112__F2 BRCA1 promotes DNA end resection, but the BRCA1-A complex suppresses excessive DNA end resection BRCA1 BRCA2 PALB2 PMC7687355__F3 Predicted activation of HGF signaling after both APAP300 and PHX GMNN TRIP13 EGR1 HGF HMMR ACKR3 NR0B2 ADGRF5 ID1 PMC7687355__F6 Temporal differences in activation of IL6 signaling after APAP300 and PHX STAT3 TNFRSF1B SLC39A14 CXCL13 EGFR IGFBP1 IL6 STEAP4 SNX10 CSF2RB CDKN1A CEBPD CEBPB PMC3517178__F2 Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression CENPF PCNA POLG MMP2 TNFSF11 SMPD1 CXCR4 IL1B RORA PMC2781439__F7 Speculative model depicting mono-ubiquitination-dependent and independent functions of the FA-BRCA pathway in DNA replication-associated repair processes RAD18 FANCD2 ATR REV1 ID2 PCNA USP1 UBE2T PMC5118428__F7 K-state regulation in domesticated and undomesticated strains tmp_locus_29 CLPP CIPC PMC12247361__F2 miR-1303 regulates cancer progression through targeting multiple genes across distinct cancer types DKK3 HEL-S-79 TLN1 SFRP1 PMC9576687__F3 Premature senescence induced by ischemia/reperfusion injury TREM1 CDK6 IL6 CDK4 PMC9576687__F2 Cellular senescence signaling pathways ATR ATM MYC PMC3909012__F7 Cell Surface Area and Membrane Folding in Glioblastoma Cell Lines Differing in PTEN and p53 Status FAS PTEN MDM2 MTOR PMC11898961__F1 Simplified 5-ALA metabolic pathway ABCB6 FECH PMC3875676__F4 High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells EGFR ERBB2 STK33 MYC KRAS PMC11931053__F8 Huoshan Dendrobium Zengye Jiedu Formula mitigates radiation-induced oral mucositis and improves oral immune microenvironment by targeting the EGFR/PI3K/AKT pathway: evidence from network pharmacology, molecular docking, and experimental validation BAX EGF EGFR PMC7687355__F8 Predicted activation of EGF and PDGF signaling after APAP300 compared to PHX at 24 hr ZFP36 EGF ZFP36L2 ETS2 RRM2 TGIF1 MYC SIAT4C ATF3 RHOB FOSL1 THBD EGR2 CCNB1 CCND1 SOX4 PMC8403340__F3 Glutamate-mediated, calcium-related signaling in glioma progression GRIA3 GRIN2B MYL10 PPP3R1 MTOR GRIK2 PCDHA1 OTOF TGFBR1 PCDHA3 TRDN RYR3 MYLK DLGAP4 DLGAP1 LRFN2 PIG59 CACNA1G FKBP1A MYL2 MYH9 ASPH GRIN1 CACNG1 CACNA1S GRM3 CACNB1 RYR2 CACNA1C HOMER1 FKBP1B CACNA1B CDH23 DLG4 GRIK1 CALN1 PCDHJ LRFN1 GRIK3 ACVR1 MYL12A CACNA2D1 CALM1 PMC6807343__F8 Proposed model IL6 TNF IRS1 IL1B PMC6073120__F4 Endocytic trafficking of PAR1 RAB11B RAB11A SNX1 ARRDC3 PMC6393786__F2 Optogenetic switches RAN PMC4932542__F1 Models that have been proposed to explain the inhibition of tumor cell proliferation by metformin IGF1 HEL-S-26 PMC5341926__F3 Proteomic analysis uncovers common effects of IFNG and IL-27 on the HLA class I antigen presentation machinery in human cancer cells ATR JUN HEL-S-20 SP100 DHFR APC MTRR OAS3 POMP TYMS AADAT PMC9367541__F2 Mutations Affecting Genes in the Proximal T-Cell Receptor Signaling Pathway in Peripheral T-Cell Lymphoma ITK GRB2 LCK PMC9367541__F1 Mutations Affecting Genes in the Proximal T-Cell Receptor Signaling Pathway in Peripheral T-Cell Lymphoma CDC42 ZAP70 SOS1 CARD11 VAV1 MTOR ARHA PLCG1 FYN BCL10 ITK GRB2 LCK PMC11799259__F2 Interaction between genes/pathways in prostate cancer (A) Rb deletion promotes the expression of genes downstream of the AR pathway through transcriptional activation of E2F and facilitating promoter recruitment of the AR PTEN MYC PMC4542378__F10 Activated signaling pathways that regulate KSHV lytic replication during primary infection EPHA2 PTK2B SRC CREB1 PMC4046911__F2 PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis ACAT2 ADRB2 GADD45B NUPR1 NFIL3 ID3 PMC3466406__F7 Biological insights obtained by combining logical modeling and experimental data EGF CDK6 HGF GSK3B GRB2 TNF CDK4 PMC4516713__F6 Brain signaling network reprogramming in response to mild mitochondrial uncoupling RHEB TSC2 TSC1 IGF1 SGK1 ATF4 IGF1R ARC BDNF PMC9267148__F6 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis TCF4 ZNF710 TGFBR1 FOXH1 CEP57 SRCAP ZNF117 LGALSL TEKT4 COL1A1 ZNF564 TRAPPC2L AEBP2 PHLPP2 FP972 CEBPD CLTA RFX4 SNX14 CSNK2A1 PLEKHG7 AXL ECT2 RELN ABCB10 RSPO1 ACACB RORC GAB2 PMC9313271__F1 Current Concepts of Vitiligo Immunopathogenesis CXCL9 CXCR3 CXCL10 PMC10937991__F8 Graphical abstract IFNG IFNGR2 PMC9267148__F7 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis PARD6A CACNA1A CIAPIN1 SKIL SHC1 ADRA1A SMAD2 ZFYVE9 SMAD4 SKI TGFBR1 ERBB3 FOXH1 NRG1 PARD3 CSNK2A1 ERBB2 PMC8514585__F2 PRMT5 in DNA damage response in prostate cancer RAD51D RAD51 RAD51AP1 BRCA1 NHEJ1 RUVBL1 BRCA2 WEE1 PMC3877845__F1 mTOR signalling pathway RHEB MLST8 TSC2 RICTOR HIF1A YY1 GRB2 MTOR PMC2808051__F20 Reversible phosphorylation regulation of the cell cycle E2F2 WEE1 ATM PMC9008451__F2 Interleukin-22 in Renal Protection and Its Pathological Role in Kidney Diseases STAT3 BAD NLRP3 TLR4 AHR CXCL10 CCL2 PMC6396373__F9 Herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐KB signaling and STING's dual role during MCMV infection TBK1 CGAS IRF3 PMC8615124__F3 Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression HEL-S-32 HEL-S-26 PMC8144889__F3 Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension WNK1 KLHL3 OSR1 PMC8144889__F2 Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension WNK1 WNK4 SGK1 KLHL3 PTH OSR1 PMC3466406__F2 The integrated large-scale logical model STAT3 FBXW8 EGF ATR HGF PCNA DMP1 EGFR EBP CDC6 PTEN MTOR MYC SKP2 MEF2C CDK6 CCNE1 CCND2 ROCK1 WEE1 ATM MDM2 SRC CEBPB CCND1 CDK4 CCND3 JUN SP1 ARHA NPAT FOS RHEB HDAC1 CEBPA CDK2 LYN GRB2 MCM2 FBXW4 PMC5239799__F1 Integration of non-genomic signaling and canonical signaling of androgen receptor (AR) BAD SRC PMC3801191__F1 Estrogen Regulation of Dkk1 and Wnt/Beta-Catenin Signaling in Neurodegenerative Disease RPS6 APC GSK3B PMC6284793__F8 Known and novel BP associations in the TGFB signalling pathway ACVR2A TGFB1 IRF7 NODAL RUNX2 SKI PITX2 RUNX3 HDAC1 FOXH1 SMURF1 INHBA TLX2 RRAS GSC MAP2K2 GRB2 NKX2-5 PMC5920792__F2 Feedback Regulation of RTK Signaling in Development PTEN CS GRB2 MTOR PMC7203229__F3 Genomic competition for noise reduction shaped evolutionary landscape of mir-4673 TCF3 CTCF NPS TFAP2A TFAP2C TCF4 TFAP2B CTNNB1 PMC6543531__F8 Regulated Necrosis and Failed Repair in Cisplatin-Induced Chronic Kidney Disease EPHB2 KCNB1 NRG1 TP53INP1 NTN1 CDKN1A NR1C2 LCN2 PMAIP1 PROC FOS PMC4888836__F1 Model for the noncanonical HDR pathways at two-ended DSBs ERCC1 RAD52 RAD51 MRE11A RTEL1 POLE PMC6657303__F4 Mitochondrial and Endoplasmic Reticulum Reactive Oxygen Species Production in Models of Perinatal Brain Injury BAX NLRP3 KEAP1 BCL2 ATF4 EIF2A PMC6557692__F1 Pro-Inflammatory Cytokine Activation of NFKB in Synovial Fibroblasts RELA TNF FADD PMC10377498__F5 Mitophagy: A Bridge Linking HMGB1 and Parkinson’s Disease Using Adult Zebrafish as a Model Organism HMGB1 FIS1 TLR4 PARK2 PMC3798933__F2 Insulin signaling pathways are inhibited by damage-associated molecular pattern (DAMP)-mediated, Toll-like receptor (TLR)-mediated pathways TLR1 PI3 TLR4 IRF3 SOCS3 TRAF3 TRAF6 IRS1 MYD88 PMC6299398__F5 Affected pathways in group 4 medulloblastoma PCDH9 SUFU GSK3B SHH PTCHD4 SMO CTNNB1 GLI3 PMC9496697__F1 GSK3 Is a Central Player in Retinal Degenerative Diseases but a Challenging Therapeutic Target POR TSC2 TSC1 PTEN REL CTNNB1 PMC8365026__F1 Endoplasmic Reticulum Stress in Cerebral Ischemia ATF4 EIF2A QRICH1 XBP1 PMC6299398__F3 Consequences of driver gene mutations in canonical Wnt signaling PIK3CA FBXW7 GSK3B IRS1 CTNNB1 PMC6299398__F2 Affected pathways in SHH-activated medulloblastoma RBX1 SUFU PTCH1 SKP1 DYNC1H1 SMO GLI3 PMC3469602__F4 Serum and Antibodies of Glaucoma Patients Lead to Changes in the Proteome, Especially Cell Regulatory Proteins, in Retinal Cells HTRA2 FAS CAD TNF DIABLO PMC11055311__F1 Main signaling pathways involved in TPL in cancer SOX17 SFRP5 PUM1 STAT3 RELA CDK2 LRP6 FZD1 MMP9 WIF1 PMC4994294__F4 Unigenes involved in the plant hormone signal transduction pathway in SAM of Oriental hybrid lily BIN2 EBF2 BAK1 PMC4124034__F3 Translational Control by Heme-Regulated eIF2A Kinase during Erythropoiesis ATF4 EIF2A RET PMC9503257__F6 Intestinal microbiome-mediated resistance against vibriosis for Cynoglossus semilaevis TBK1 ACOX1 TLR1 TLR3 TANK IRF3 IRF7 TRAF3 ELOVL5 CYP27A1 RAC1 PMC5286530__F1 FGFR signaling pathway TES STAT3 FGF7 STAT1 FGF22 TK1 FGF21 FGF5C GRB2 FGF10 PMC7701218__F9 Proposed CCN3-mediated signaling pathways in placental diseases PE and AIP CDK2 NOTCH1 CDK4 PMC11928779__F8 A‐KG and tRNA deoxygenation in the cytosol and mitochondria ALKBH1 NSUN2 NSUN3 FTSJ1 PMC4036111__F3 Schematic of the FGFR signaling pathway FRS2 FGFR1 FGF2 PMC3616322__F2 Signalling regulation of mammalian autophagy RHEB TSC2 TSC1 PTEN GRB2 IRS1 PMC10530385__F1 Tet1 regulates pathways responding to PM2.5-induced oxidative stress HEL-S-72p TGFA KEAP1 EGFR IL33 HIF1A AREG CYP1A1 XBP1 HMOX1 DNAJB9 NQO1 AHR TRAF2 IL1B PMC8365026__F3 Endoplasmic Reticulum Stress in Cerebral Ischemia EIF2A TRAF2 PMC7377944__F2 Human telomerase in homeostasis and disease DCP2 ZCCHC7 XRN1 TGS1 TERT PABPN1 PMC8645129__F8 Development and characterization of efficient xylose utilization strains of Zymomonas mobilis RP1 REST MAF PMC7643412__F4 Crosstalk between ferroptosis and apoptosis, necroptosis, autophagy-dependent cell death and pyroptosis RIPK3 BAX CHAC1 MLKL GPX4 RIPK1 SLC7A11 SDC1 APAF1 PMC7643412__F3 Published molecular mechanisms of ferroptosis in breast cancer RIPK3 STAT3 MTDH CHAC1 GPX4 MLKL RIPK1 SLC7A11 ATF4 EIF2A SRC HEL-S-64p PMC11928134__F7 HPS1 and ITK function in melanocyte and T-Cell IL2 ITK IL6 TNF HPS1 PMC7643412__F1 Ferroptosis pathways IPP HMGCR KEAP1 GPX4 LPCAT3 BAP1 DPP4 HEL-S-102 FACL4 HEL-S-64p PMC7730978__F1 Gain of function (GOF) effect of mutant p53 and regulation of autophagy by p53 in nucleus BAX TSC2 PML PTEN MDM2 MTOR PIN1 PMC6752729__F1 Summary of molecular basis on which epigallocatechin-3-gallate (EGCG) prevents chronic kidney disease (CKD) and renal fibrosis based on preclinical evidence CDH2 NLRP3 NQO1 CTNNB1 MPO PMC11928779__F5 MTOR signaling network RHEB MAF1 MLST8 CASTOR1 DEPTOR EIF4E PMC5676564__F1 Representative signalling pathway of human TLRs in the cell membrane (TLR1/2, TLR2/6, TLR4, TLR5, and TLR10) and endosome (TLR3, TLR4, TLR7, and TLR9) TBK1 TAB3 MAL TLR9 IRF3 IRAK2 IRF7 IRAK4 MYD88 TLR3 TLR4 TLR7 TLR10 PMC6433747__F1 Androgenic-inducible miRNAs involved in the process of BC progression CD44 KRAS SOX4 PMC11927577__F3 KEGG signaling pathway analysis of up-DEGs and down-DEGs in AD PIDD1 GM2A CYTH1 FLNB CTSH CTSL CTSS MAP2K2 NCKAP1 PMC8774449__F1 Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases CYP2R1 CYP24A1 DHCR7 CYP3A4 PMC7738566__F3 Enhancer effects in establishing cancer signaling environments FAT4 FLT3 RAF1 SOS1 KEAP1 SMAD2 GSK3B SMAD4 NTRK3 MYC FGFR2 RB1 CDKN2A FBXW7 CDK6 CSNK1E CCNE1 ALK NF1 NCOR1 ERRFI1 FGFR1 MXD3 RIT1 MAPK1 TAOK1 TAOK2 MXD1 MNT APC NTRK2 PCDHJ YAP1 RHEB ERBB3 RICTOR CDKN1A PSEN2 AXIN1 SFRP5 MAX DKK4 STK11 STK4 TGFBR1 TGFBR2 MGA MDM4 MAML3 CDKN2C CCND2 INPP4B MLX CHEK2 JAG2 NF2 MXI1 CCND3 CRB1 ERBB4 KDM5A KIT PPP2R1A TCF7L1 RAC1 AXIN2 SFRP1 ARAF CBL ARRDC1 WWC1 PDGFRA TAOK3 CREBBP ERBB2 EP300 CRB2 DKK1 FGFR4 MYCL MDM2 ROS1 ACVR2A MXD4 CSNK1D TLE4 SFRP4 CDKN1B CDK2 FAT1 ZNRF3 RET EGFR BRAF IGF1R PTEN CDKN2B MTOR DCHS1 CTNNB1 TLE2 LATS1 MOB1A TEAD2 ACVR1B ATM DKK2 CCND1 DNER MLXIP CDK4 RPTOR SPEN TLE3 PTPN11 DKK3 NCOR2 RNF43 NTRK1 FGFR3 MAP2K1 MAP2K2 FAT2 FAT3 KAT2B WIF1 PMC8152475__F9 Multi-Functional MPT Protein as a Therapeutic Agent against Mycobacterium tuberculosis TBK1 HK2 IRF3 PMC9339490__F2 Glioma-neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review) MMP3 ADAM10 LYN MMP9 SRC PMC5798144__F6 Egulation of actin cytoskeleton pathway and the differentially expressed genes on the bare and the TiN-coated NiTi alloys CDC42 ABI2 HEL114 GAL PXN F2 APC RHO INS DOCK1 PMC5798144__F4 TGFB signaling pathway and the differentially expressed genes in both the bare and the TiN-coated NiTi alloy groups LTBP1 SP1 FRK SMAD2 SMAD4 NODAL ARHA PITX2 TGFBR1 BAMBI IFNG RBX1 E2F4 FST SKP1 PMC9610432__F4 Foot-and-Mouth Disease Virus: Molecular Interplays with IFN Response and the Importance of the Model TANK PMC9610432__F3 Foot-and-Mouth Disease Virus: Molecular Interplays with IFN Response and the Importance of the Model IFNG TRIM25 IRF9 CD14 TANK MAP3K7 TYK2 PMC523881__F1 The monolignol biosynthetic pathway CAD ACD PMC10454457__F3 Constitutively expressed genes of class I and II major histocompatibility complex processes of endogenous and exogenous antigen processing pathways found in chicken thrombocytes HEL-S-99n TAPBP CANX CD74 TAP1 B2M TAP2 PMC10454457__F2 Genes of the TLR signaling pathway observed in chicken thrombocytes TIRAP TANK TLR9 CD14 TLR5 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR7 PMC11871217__F7 Deduced signaling pathways regulated by LvMmd2 LATS1 BAD RAF1 PAQR3 MMD2 PMC11705844__F7 The mechanism by which BMAL1 deficiency impairs cognitive function EGFR BACE1 APP AREG PMC9118424__F6 Transcriptome and Metabolome Analysis of the Synthesis Pathways of Allelochemicals in Eupatorium adenophorum MVD FDPS PMC9464914__F1 Pinocytotic engulfment of lipoproteins by macrophages CDC42 ACAT1 CCL19 TLR4 AKT3 CWC22 CD47 RAC1 PMC9160457__F9 Attenuation effect of potassium 2‐(1‐hydroxypentyl)‐benzoate in a mouse model of diabetes‐associated cognitive decline: The protein expression in the brain CLASP2 DRP2 HINT1 LAMTOR2 MTOR HAGH PMC6435963__F1 Complement activation cascades and functions MASP1 MASP2 HEL-S-62p C4A PMC3930409__F10 Epidermal growth factor (EGF-EGFR) signalling pathway in hepatocellular carcinoma (HCC) inflammatory microenvironment EGF CXCL5 EGFR IL8RB CXCL8 PMC3901225__F2 Protein complexes and their connection with metabolism PTS POLI PMC6435963__F2 Regulation of complement activation by RCAs or parasite-expressed proteins targeting different complement components at the different steps of complement activation MASP1 CD59 VTN CR1 CP PMC6600670__F8 Mechanism by which EPD attenuates IMQ-induced psoriasis by inhibiting the inflammation responses via TLR7/8–MyD88–NFKB–NLRP3 inflammasome signaling pathways NLRP3 TLR8 TLR7 TRAF6 MYD88 PMC8306788__F1 Hippo Signaling Pathway as a New Potential Target in Non-Melanoma Skin Cancers: A Narrative Review LATS1 LATS2 PMC4025940__F1 Roles of TGFB in the tumour microenvironment TGFBR2 SMAD4 MTOR TGFBR1 PMC2874439__F3 Schematic representing the significant changes in gene expression in the lung of Keap1Δ2–3/Δ2–3;CctCre+ mice compared with Keap1flox/flox mice GPX2 HEL-S-128m AOX1 BACH1 ABCC1 EPHX1 GCLM GCLC HEL-75 PMC7122036__F1 Transforming growth factor B (TGFB) signaling in aortic aneurysms and dissections (AAD) SMAD2 SMAD4 PMC8229934__F5 Sildenafil Counteracts the In Vitro Activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 Axis Induced by Reactive Oxygen Species in Scleroderma Fibroblasts CXCL9 CXCL11 CXCR3 STAT1 CXCL10 PMC3328609__F3 Development of the Bile Ducts: Essentials for the Clinical Hepatologist APC GSK3B CTNNB1 PMC11505293__F4 Polycystic Ovary Syndrome and Ferroptosis: Following Ariadne’s Thread TET2 PINK1 GPX4 ASCL4 SMAD2 FACL4 PTEN HIF1A INS SIRT3 TFRC ACVR1B DPP4 MUC1 ATM MUC7 PHF21A SLC11A2 TET1 HAMP PCBP1 IL6 FTL NFKB1 NFE2L2 PMC5372284__F4 Phospho-sites identified in proteins of the RAS-RAF-MAPK and PI3K-AKT signaling pathway in a lung adenocarcinoma cell line harboring a L858R mutation in the kinase domain of EGFR, which is reactive to treatment with erlotinib RPTOR EGF GRB2 EIF4E PMC11505293__F2 Updated PCOS network: network depicting the associations (connecting lines) of PCOS-relevant genes/gene products (nodes) CGA CCK PINK1 NEIL2 GPX4 KCNA4 THADA FACL4 MGLL MAPK8 CXCL8 FANCC TRIM28 NCOR1 PHF21A ZNF41 DCN GPT ZKSCAN5 KRR1 SLC11A2 CAST RAD50 HHEX IRF1 HAMP IL1A TNF TOX3 TROAP TCF7L2 GHSR SULT2A1 BCL2 AVP BMP15 FBN3 DLG2 TET2 MAPRE1 ASCL4 CAPN10 PTEN SLC7A11 SETDB1 INS SIRT3 TFRC ACVR1B SHBG NR3A2 TLR4 DPP4 LDLR MUC1 CNR1 MUC7 AMH ACE2 IL1B ZSCAN20 CYP21A2 CYP17A1 FTSJ1 ERBB4 TET1 PRDM2 HEL-S-89n PTPN11 PCBP1 BCL2L11 FSHB HEL-68 GCG BYSL KISS1 KDM1A FTL ITGB1 GNRHR NFKB1 NFE2L2 EP300 AMHR2 TRIM4 KISS1R ZBTB16 RPS9 GATA4 DCTN1 PS1TP5BP1 PMC7865768__F4 Domain structure of SPAK and the phosphorylation target sites on NKCC1 and KCC3 OSR1 WNK3 PMC7462086__F2 SOS1 Gain of Function Variants in Dilated Cardiomyopathy HGF RAF1 SOS1 BRAF CS MAP2K1 GRB2 PMC1456930__F5 The molecular pathways controlling AB generation during aging IGF1 PTEN IGF1R PMC3163738__F3 IFNA (type-I IFN) and IFN-λ (type-III IFN) signal through distinct receptor complexes, but activate the same intracellular signaling pathway IFNK STAT1 STAT2 IFNAR1 MX1 IRF7 JAK1 TYK2 PMC10222048__F3 KEGG pathway analysis of glycolysis and gluconeogenesis PCK2 PFKFB1 G6PC2 PDHA1 PGM2 CPM LDHB ENO1 ALDH3B1 ACSS1 PMC8446806__F1 Complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain C6 C7 C5AR1 HEL-S-62p C1S C1R CR2 VTN CR1 MASP1 C5AR2 C2 C9 C4B_2 PMC3956809__F4 Tissue-specific expression within individual functions—a case of insulin signaling pathway PPP1R3E ARHG FASN PTPRF FLOT2 MTOR FAP HRAS HEL-S-42 CTCF PRKCI FBP2 PRKAA2 PRKAB2 PMC6786387__F11 Proposed model illustrating the mechanism that underlies NTZ in the amelioration of AD pathology NQO1 GSK3B MTOR PMC12210724__F1 Association of SNPs in carbohydrate metabolism genes with insulin resistance indicators in the Mexican population SLC2A4 HK3 IDH3B SUCLA2 PC HEL-S-32 MDH2 GCK SLC2A7 SLC2A8 GOT2 SLC2A14 SLC2A11 SLC2A10 HEL-S-133P HK2 SLC45A1 HEL-S-278 SLC5A4 SLC2A2 SLC2A3 LDHB PPM2C SDHD PDP2 PDHX SDHA RPE PGAM1 SDHB PGAM2 PDHA1 HEL-S-304 ALDOB ENO3 FBP2 RPIA HEL-S-68p OGDH SUCLG2 DLD ENO1 PDHA2 SDHC HEL107 ENO2 PDK2 CS PCK1 SUCLG1 SLC5A2 SLC2A9 FH ACO2 SLC5A1 PDK3 DLAT PDK4 SLC5A9 PFKP SLC2A6 FBP1 PFKL HEL-S-87p PMC6993488__F3 Inhibiting T cell activity causes anti-PD-1/PD-L1 immunotherapy resistance PTEN TNF PMC5235905__F9 LPS/TLR4 engagement promotes AMPK dephosphorylation and decreased kinase activity in peritoneal macrophages TLR4 IL1B MYD88 PMC7096153__F2 Ingenuity Pathway Analysis GRIA3 GNAO1 GLS SLC1A3 AKT3 PTPA BRAF ATP2A2 MEF2C PRKCB MAP3K2 CAMK2A PRKCE YWHAQ GUCY1A2 GRM3 MAPK1 RYR2 KRAS GRM2 PLA2G2C MEF2D PAFAH1B1 PAWR PLCB1 MAPK10 SLC1A2 ADCY1 PMC5338169__F2 The endothelial cell and monocyte in early stages of atherosclerosis: potential mechanisms of milk derived bioactive peptides CD36 TLR4 CCR2 PMC9033766__F6 Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways COL1A1 TNF RUNX2 PMC5524345__F9 Dkk3 gene encodes a vital intracellular regulator of cell proliferation APC LRP5 LRP6 CTNNB1 PMC8632642__F8 Co-Exposure of Cardiomyocytes to IFNG and TNFA Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy NOS2 STAT1 SIRT1 PMC8594130__F6 Knockdown of long noncoding RNA GAS5 reduces vascular smooth muscle cell apoptosis by inactivating EZH2-mediated RIG-I signaling pathway in abdominal aortic aneurysm TBK1 IRF3 PMC8234993__F4 Molecular Human Targets of Bioactive Alkaloid-Type Compounds from Tabernaemontana cymose Jacq. RHEB ENG BAD BCR RBL2 CYC1 CD19 PTEN APIP MDM2 PMC8204019__F4 Radiation Resistance: A Matter of Transcription Factors KEAP1 GPX4 EGFR NQO1 GCLC HES1 NOTCH1 PMC8204019__F3 Radiation Resistance: A Matter of Transcription Factors ATM CCNB1 TNF CCND1 PMC9564311__F5 Potential Fatty Acid Metabolism-Related Gene Signature for Prognosis in Clear Cell Renal Cell Carcinoma CPOX ENO2 ENO3 HPGD ACADL CPT2 ALDH3A2 PMC11853788__F4 Proposed regulatory network involving relevant metabolic pathways in Longissimus dorsi muscle (LDM) after composite plant extracts (CPE) addition CTRL BAX HEL-S-130P PLA2G4E PIK3R1 PC PLA2G2D PMC2981398__F1 Role of the N-end rule pathway in RGS protein degradation RGS2 NTAN1 RGS10 RGS11 RGS8 RGS7 RGS18 RGS6 RGS17 RGS5 RGS4 RGS13 RGS1 ATE1 PMC7256023__F1 TGFBeta-induced epithelial-to-mesenchymal transition CDH2 SNAI1 SMAD2 SMAD4 TWIST2 ZEB2 RHO SMURF2 TWIST1 TGFBR1 PMC4105632__F1 Nigrostriatal, mesocortical, and mesolimbic pathways TH SST PMC4405749__F6 Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis BAX FOXO1 SIRT1 PMC6129280__F5 piMGM: incorporating multi-source priors in mixed graphical models for learning disease networks PIK3CA MAPK11 MAPK13 PI3 AKT3 PIK3CD PIK3R1 NFATC1 MAPK12 PPP3CA PMC8284093__F7 Genomic Response to TGFB1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney RASSF6 SMAD1 AFP PATJ AMOT APC SMAD4 CTGF AXIN2 PMC9201920__F3 Non-Coding RNAs as Novel Regulators of Neuroinflammation in Alzheimer’s Disease TREM2 IL1B MYD88 PMC7256023__F5 Lipid and choline metabolism in TGFBeta-induced EMT ACLY TBR1 MMP7 SNAI1 SMS FASN CHKA PMC7256023__F3 TCA cycle is active in TGFBeta-induced EMT SDHD SDHA SDHB FH SDHC PMC8069677__F4 Effect and regulation of the NLRP3 inflammasome during fibrosis NLRP3 TLR4 SMAD2 TGFBR3 SMAD4 NOX4 IL1B PMC6314405__F1 Immunological pathways targeted by the main novel therapies for IBD TH MADCAM1 ELL PMC11907837__F2 Wnt/Beta-catenin-related ncRNAs that regulate tumour cell proliferation, metastasis and invasion BRD4 FOXR2 VAPA APC PLAGL2 EZH2 CTNNB1 PMC11907837__F1 Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 CTNNB1 PMC11052502__F4 Results of PPI, KEGG, Reactome, and GO analysis of 19 common proteins that were targets of 1-MNA and RA-associated gene targets GSTM2 GSK3B MMP9 PARP1 EIF4E MAPK14 INSR PDPK1 F10 MMP3 CDK2 PDE4D LCK PMC4794722__F2 Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia OXCT1 ETFDH ETFB ACADS PLIN5 KCNE2 NR0B2 ACADM PEX26 ESRRA LIPA NR1C1 ETFA APOB ACADVL PPARGC1A CPT2 PSAP CYP4A11 PMC5223024__F1 TLR and the related TNFR and IL-1R signaling pathways TRADD TIRAP RELA CD14 IRF3 IL6 TRAF3 TRAF6 TNF TRAF2 IL1B MYD88 PMC7560924__F5 Resistance and response to insulin by mTORC1 RHEB TSC2 TSC1 GRB2 PMC3787928__F2 Action of Smac mimetics.Notes: IAPs are important regulators of NFKB-activating signaling pathways SHARPIN MAP3K7IP1 TRADD SMS RELA RELB IL6 TRAF2 FADD PMC3418637__F1 Context-dependent effect of PI3K signaling on Treg development, differentiation and maintenance FOXP3 PMC8670233__F2 Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases LOX EBP PMC8527296__F1 Putative type I interferonopathy genotypes SOCS1 CGAS PSMD12 C1QB POMP BLM ENPP1 STAT1 ADA2 RNASET2 USP18 PSMB10 ATM LSM11 ISG15 NGLY1 OAS1 DNASE2 STAT2 PSMB8 PNPT1 COPA SAMD9L RNASEH2C RNASEH2B RNASEH2A ATAD3A POLA1 C1QA IFNAR2 IFNAR1 C1QC JAK1 TREX1 PMC2394659__F3 Aged Retinal Pigment Epithelium/Choroid: A Potential Substratum for the Pathogenesis of Age-Related Macular Degeneration CD44 CRK JAM2 ARHH PXN THY1 NCF4 ARHA RAC1 CD99 PMC9139716__F3 Brain Organization and Human Diseases SMAD1 DKFZp781O1323 SIX3 PTCH1 NOG FGFR1 SHH SMAD4 SMO NODAL PMC317355__F3 Wnt-signaling pathway APC GSK3B LRP5 LRP6 TEF CTNNB1 PMC10520073__F7 Graphical representation of the regulation mechanism underlying ABC variant rs4810856 and CRC risk TF STAU1 PREX1 PTEN PMC9030470__F3 Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis ME3 RBBP7 RBBP4 PRC1 RYBP PMC6959099__F2 Metabolic changes associated with innate immune responses in lung disease TSLP FAS IL33 PMC2409816__F1 Schematic representation of the major pathways of ganglioside biosynthesis SAT2 GAL ST8SIA1 B3GALT4 PMC5372671__F1 Mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway RHEB UBE3A TSC2 TSC1 CYFIP1 NF1 PTEN DEPTOR EIF4E PMC6959099__F1 Catabolic and anabolic metabolism in the cell ASL HEL-S-162eP ARG2 PMC4387288__F2 BCL6 targets Tfh genes mainly involved in T cell signaling, differentiation, and migration pathways to drive the GC Tfh phenotype STAT3 KLF2 IFNGR1 PRDM1 IL2RA MTOR TBX21 RORA GATA3 TGFBR1 TGFBR2 IFNG IL1R1 STAT1 IL2RB CCR6 CCR7 STAT4 FOXP3 IL23R BCL6 PMC3101870__F1 Three levels of regulation of the IGF-IR pathwayand its components IGF2R BAD GHRH PTEN IGF1R GRB2 MTOR PMC4335252__F10 Molecular mechanism of attenuation of the PI3K/Akt signaling pathway by gingipains BAD MTOR PMC3145576__F5 Pathway analysis of proteins detected at elevated concentrations during time course analysis in lung following intratracheal instillation of 20 μg carbon nanoparticles (CNP) VWF CCL22 F7 IL4 TNF IL1B PMC3266776__F2 Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma CDC2 E2F2 SKP2 APAF1 PMC6014593__F2 Summary schematic of eye morphogenesis pathways CDC42 RPE TRIO ARHA RAC1 PMC5138592__F5 Identification of critical paralog groups with indispensable roles in the regulation of signaling flow MDK DTX1 ITCH SMAD2 DTX4 DLL4 GSK3B ADAM17 JAG2 ADAM10 LFNG MFNG DLL3 LEF1 NOTCH1 UNK PMC7789255__F2 Possible paracrine mechanisms controlling differentiation of spermatogonia in adult testis STRA8 CYP26B1 SOHLH2 HEL-S-53e CRABP2 LRAT RXRA RBP4 RDH10 FSHR NANOS2 PMC7789255__F1 Possible paracrine mechanisms controlling self-renewal of spermatogonia in juvenile testis CYP26B1 CYP26C1 LIN28B GDNF SOHLH1 LRAT RDH11 SOHLH2 REC8 CRABP2 CRABP1 RDH10 ZBTB16 RET CYP26A1 PMC5883534__F4 BRAF kinase inhibitor resistance and alternative activation of MAPK targets and pigmentation TF SMAD9 PLCB4 HGF CREB3 EPHA2 OCA2 SMAD2 DCT DUSP2 YAP1 EFNA2 PDGFRA PDGFC FGFR1 EDNRB EP300 ADCY1 PMC4439419__F1 Cell cycle arrest in senescent cells CDK6 APC CDK2 CDK4 PMC2633067__F2A Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells ABI2 HEL114 DOCK10 PXN F2 APC HEL-S-11 RHO INS PMC3982775__F1 Structure of the systems model of type C4 photosynthesis HPR MAL GCA GIP PMC4051248__F9 LPS up-regulates the PhT2 signaling pathway TIRAP TLR4 CD14 MYD88 PMC7509264__F1 Resolution of inflammation in immune and nonimmune cells by interleukin-19 IL20RB STAT3 IL19 IL20RA PMC3191051__F9 Model for TGFB1-mediated signaling to the miR143/145 regulatory region TGFB1 SMAD2 SMAD4 MYOCD PMC3257565__F2 HSC cell cycle entry is regulated by a complex network of cell-intrinsic and cell-extrinsic factors BMI1 TSC2 CDK6 TSC1 JUNB CDK2 TPO PTEN MTOR HES1 CDK4 PMC8291015__F1 Impact of the COVID-19 pandemic on inflammatory bowel disease patients: A review of the current evidence TMPRSS2 ADAM17 ACE2 PMC3405739__F2 The processes included in the insulin model PI3 PTEN PMC8114202__F5 Thyrotrophin and thyroxine support immune homeostasis in humans CD40 TLR9 TLR8 IRAK1 IRF7 TLR7 TRAF3 TRAF6 PMC3007169__F1 Arsenic: a potentially useful poison for Hedgehog-driven cancers SMO PMC9379413__F3 Phase separation in Cancer: From the Impacts and Mechanisms to Treatment potentials LATS1 DACT1 BRD4 APC GRB2 MED1 CTNNB1 PMC4101819__F1 Key signaling pathways involved in genetic methylation of lymphoid malignancies APC GSK3B MDM2 CTNNB1 PMC8453085__F5 Th17 Cells in Periodontitis and Its Regulation by A20 GSDMD NLRP3 RIPK1 PMC5759028__F8 KRAS/TGFB/p15Ink4b pathway controls the cell fate RB1 EGR1 TGFB1 KRAS PMC3736320__F1 Déjà vu: EGF receptors drive resistance to BRAF inhibitors EGF NRG1 HGF PTEN IGF1R PMC6520855__F2 Targeting the Hedgehog pathway BRD4 KIF7 DYRK1B SMO PMC6520855__F1 Hedgehog pathway in absence (a) and in presence (b) of HH ligand ADRBK1 DYRK2 DYRK1A KIF7 SUFU GSK3B SMO PLK1 GLI3 PMC6751615__F5 Possible pathways for the synthesis of bioactive stress mediators from the arachidonic acid (AA) cascade in the immune tissues of chickens TES COX1 SET PMC9395317__F4 Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy CDH2 STAT3 EGF CXCL12 IL10 HGF SMAD2 APC GSK3B SMAD4 MMP9 ARHA PDK2 CCL2 CTNNB1 MAP3K7IP1 IL18 GRB2 SRC CXCR4 PMC7900639__F2 Drug induced ER stress response regulation in trypanosomes: (a) Elevated expression of Sirtuins in ER stress might activate autophagy by deacetylating ATG proteins, and sirtuins regulate subsequent switch to apoptosis at a higher stress level UBA5 UFM1 EIF2A ATG5 PMC6992650__F5 Kaposi sarcoma-associated herpesvirus infection pathway from KEGG MIA STAT2 FRK NPAT PMC8268416__F1 Plant responses to geminivirus infection: guardians of the plant immunity GRIK1 ATG5 EML1 PMC1937548__F4 Comparison of nonsynonymous substitution rates among members of RB and p53 signaling pathways CDK6 MDM2 CDK4 PMC5835320__F7 Canonical pathway analysis for genes determining cellular responsiveness to As2O3 using Ingenuity Pathway Analysis ATAT1 GULP1 DNAJC8 EGFR IGFBP1 SPDEF RHO MYC TCF19 CPD RYR3 RBBP4 ASAP2 GCA CNTRL ABLIM1 CCND1 ABCC2 CMTM4 COASY CDS2 IKZF1 BACH2 ANXA3 NXN KNTC2 PKP3 ME1 SDC1 ARHGAP19 ID1 MRPL37 CAT56 ACTR2 TCF7L2 SF3A1 AURKB NFKB1 PLPP2 IRF2 BTN2A1 CP PMC5835320__F6 Network pharmacology for genes determining cellular responsiveness to As2O3 using Ingenuity Pathway Analysis IGFBP1 SPDEF MYC TCF19 CPD RYR3 RBBP4 MYL3 HEL-S-171mP PLS1 GCA CNTRL ABLIM1 CCND1 TFDP2 CMTM4 COASY IKZF1 BACH2 ANXA3 NXN KNTC2 PRIM2 PKP3 ARHGAP19 ID1 MRPL37 CAT56 ACTR2 TACC2 GRB7 TCF7L2 SF3A1 AURKB NFKB1 IRF2 COX11 PMC6912660__F1 The main estrogen receptors signaling pathways: in the genomic pathway, classic estrogen receptors (ER A and B) act as transcription factors upon homo- or heterodimers EGF SOS1 BRAF PMC3390969__F2 Impact of a negative regulator on pathogenesis and the development of sepsis, secondary to acute insults CD14 CD163 TRAF6 MYD88 PMC9513370__F3 Crosstalk between dendritic cells and regulatory T cells: Protective effect and therapeutic potential in multiple sclerosis AHR FOXP3 TNF PMC9513370__F2 Crosstalk between dendritic cells and regulatory T cells: Protective effect and therapeutic potential in multiple sclerosis CD80 TSLP FOXP3 LAG3 PMC4887024__F5 Feed Efficiency within a Pedigree Male Broiler Line: I. Highlight on Mitochondria HEL-S-31 IDE LDB3 PPIB RPL12 ARF1 CTH FABP4 ACTA1 RPL30 GPX1 PSMD2 PSMD1 ALB RYR3 RICTOR INSR NFE2L2 AAG1 PAH PPA2 PFKM HEL-S-44 PMC10239456__F3 Interaction graph and dynamic behavior of the PanNETs Boolean model PDX1 MEN1 PTEN MDM2 MYC SKP2 PMC7022928__F1 Retinoic acid signaling pathway CRABP2 LRAT RBP4 PMC2908393__F5 Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy APOE LDLR ABCA1 PMC5275772__F4 Beneficial effects of hepatic CAV‐1 on atherosclerosis protection in DKO mice TG FAS LDLR CYP27A1 PMC5854367__F1 Most of Theileria parva proteins involved in glycolysis and tricarboxylic acid cycles were identified in this study FH OGDH HEL-S-68p HEL-S-162eP PC PMC2908393__F4 Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy IDE VLDLR LDLR PMC2908393__F3 Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy BACE1 LRP1B PMC4845657__F7 Nuclear factor KB1/RelA mediates inflammation in human lung epithelial cells at atmospheric oxygen levels NFKB1 RELA TNF PMC9647533__F7 MicroRNA-16 inhibits the TLR4/NFKB pathway and maintains tight junction integrity in irritable bowel syndrome with diarrhea TLR4 IL6 IL1B PMC9684507__F6 rs28714259 risk (A) allele dysregulates genes following dexamethasone/doxorubicin combination treatment and contributes to an attenuated hypertrophy signaling PLD6 PDE10A EIF4EBP1 DIAPH2 IGF1R RHO PMC6750724__F5 Proposed biosynthetic pathway of pepticinnamin E MT3 PCM1 HEL-S-62p C2 PMC8225795__F3 Comparison of genetic alterations of signaling pathways in AFPGC and TCGA-GC ATR EGFR MCL1 BRCA2 PTEN CDKN2B MTOR MYC FGFR2 RB1 CDKN2A CDK6 CCNE1 NF1 FGFR1 ATM MDM2 CCND1 CDK4 PIM1 ERBB4 VEGFA ERBB3 TSC2 BRCA1 ERBB2 EP300 MAP2K1 PMC10034899__F1 Sirtuins in attenuating plaque vulnerability in atherosclerosis HMGB1 NLRP3 IL6 PMC3730813__F2 Pattern Recognition Receptors in Intestinal Inflammation TLR3 TLR4 NOD2 TLR5 IRF3 NOD1 TRAF6 MYD88 PMC10486880__F4 Anti-cancer mechanisms of leeks and their active compounds BAX MTOR ATG5 PMC3730813__F1 Pattern Recognition Receptors in Intestinal Inflammation NLRC4 NLRP3 IL1B PMC4996775__F9 Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson’s disease TF RPE HP PMC9309601__F2 Cytokine storm: behind the scenes of the collateral circulation after acute myocardial infarction SMAD1 DKFZp781O1323 PI3 SMAD2 CCR2 ACVRL1 CCL2 IL1B TGFBR1 PMC6316710__F1 NCOA4-mediated ferritinophagy pathway is regulated by intracellular iron HERC2 FTH1 COIL PMC9289867__F4 Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways PMC5859839__F11 Pathway of compound-known target-ER-positive breast cancer network (blue circle stands for compound target; red diamond stands for pathway; green hexagon stands for herb) EGF RAF1 ADRA1A PTEN ACACA PPP3CA MTOR MYC CCL2 PRKCB IFNG BCL2L1 INSR NR3A2 PRKCA SI CHUK MMP2 MMP3 IL2 KDR IL1B HSP90AB1 CDC2 BAX NOS2 IL10 JUN SELE HK2 IL4 IRF1 CXCL2 CD40LG PTGS2 IL6 TNF FOS SPP1 CHRM2 RELA IKBKB RXRA NFKBIA BCL2 MAPK10 SIRT1 PMC8141035__F5 The actions of Pirh2 and KLHDC10 in mammalian RQC NEMF PTRH1 ANKZF1 KLHDC10 PMC8786145__F2 Renal Sensing of Bacterial Metabolites in the Gut-kidney Axis OR51E2 MTOR PMC8650627__F8 Prediction of the Molecular Mechanisms Underlying Erlong Zuoci Treatment of Age-Related Hearing Loss via Network Pharmacology-Based Analyses Combined with Experimental Validation PPARG EGFR CS DRD3 GABBR1 STAT1 DRD2 DRD4 SSTR2 CNR2 IL18 CNR1 MMP3 IL2 PC APP SRC GRM3 NOS2 PTGER3 JUN PTPN11 PTGS2 OPRM1 VEGFA IL6 TNF GRM2 ERBB2 PMC3893527__F4 Signal pathways involved in renal IRI BAX TLR4 IL1B MYD88 PMC4314580__F2 Signaling pathways in T/NK-cell proliferation SYK TRADD TRAF5 TRAF1 LYN TRAF3 TRAF2 CTNNB1 PMC3004747__F1 Fucose is on the TRAIL of colon cancer EGF FUT8 POFUT2 POFUT1 PMC4314580__F4 Treatment strategies for inactivating EBV infection or EBV-associated oncogenic pathways SYK BCR LYN MDM2 PMC7767644__F1 Autophagy is mediated by multiple signaling pathways that creating an interaction network system RHEB TSC2 TSC1 ULK1 FOXO3A MTOR PMC6588588__F2 T cells are differentiated into multiple T cell subtypes including Th1, Th2, T-fh, Th17 and T-reg cells STAT1 STAT4 FOXP3 BCL6 TBX21 GATA3 PMC1133795__F3 Functions of NFKB1 and NFKB2 in immune cell biology LTB LTA RELA RELB PMC11431580__F2 Schematic presentation of the interaction between estrogen receptor (ER) and the PI3K/AKT/mTOR pathway CDC2 CDK6 PLK3 CDK2 MTOR CDK4 PMC6140770__F9 Regulation of AMPK signaling in DM1 muscle STAU1 MBNL1 DMPK SIRT1 PMC11431580__F4 PI3K (phosphatidylinositide 3-kinases)/PTEN (phosphatase and tensin homolog gene)/Akt pathway PTEN MTOR PMC8998487__F3 SUMO E3 Ligases in Signaling Pathway of Cancer Cells HEL113 PML TWIST2 PTEN SMURF2 SLX4 RAC1 PMC7396583__F8 Model illustrating potential regulation mechanism of membrane lipid metabolism in peanut cold tolerance LPA ACOX1 DGAT1 GPAT2 PC PMC5938282__F5 Unique genetic cassettes in a Thermoanaerobacterium contribute to simultaneous conversion of cellulose and monosugars into butanol ENO2 HEL-S-162eP PTS XYLT1 HBD ENO1 PMC4208312__F1 B-cell receptor (BCR) and its downstream pathways SYK CD79B CD79A AXL BLNK PTEN CD19 MTOR BTK BCL10 BCR PLCG2 LYN PMC120784__F8 Outline of the cell integrity pathway ROM1 PMC6235217__F2 Pathway analysis within the identified metabolites in the (a) tocilizumab plus methotrexate, (b) tocilizumab, and (c) methotrexate strategy arms LPA LOX COX1 COX2 PC CERS6 PMC7755393__F10 Oxidant quenching cycle drives the proton leak in MS-275-treated adipocytes ECHS1 PRDX3 ACADS HEL-S-5 PRDX5 UCP1 ACADL CPT2 CPT1A GPX1 ACADM DKFZp686O2396 PMC4208312__F4 Multiple event model for B-cell lymphomagenesis SYK BTK AXL BCL10 BCR PLCG2 CARD11 BLNK CD19 PTEN LYN MTOR PMC9647636__F10 Crosstalk between TBK1/IKKE and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury TBK1 STAT1 TLR4 IRF3 JAK1 TYK2 PMC11854110__F2 Action of circRNAs participated in the chemotherapy resistance of cancer STAT3 STK11 RAF1 SMAD2 SMAD4 YBX1 IL6R WNT2B CTNNB1 PMC7318814__F6 Summary of mechanisms of action underlying MEMP HT in BC cells ELF5 RUNX2 PMC9686736__F4 Targeting Mitochondrial Metabolism to Reverse Radioresistance: An Alternative to Glucose Metabolism STAT3 BAX HEL-S-62p ATM SSB PMC8867251__F7 Inhibition of the VEGF signaling pathway attenuates tumor-associated macrophage activity in liver cancer MTOR PMC9386506__F6 Microsatellite DNA-derived oligodeoxynucleotide attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting the HMGB1-TLR4-NFKB signaling pathway HMGB1 MAP3K7IP1 TLR4 TAB3 IRAK1 TRAF6 IRAK4 MYD88 PMC6425874__F3 Protein networks around RXFP2 (red) MC1R GPBAR1 GNB3 AVPR2 GNB2 RLN2 RLN3 RXFP4 GCGR FSHR INSL3 RXFP2 GNB1 GCG RXFP3 GNB4 GPR176 GIPR PMC10932966__F1 Two Sphks play different roles STAT3 NLRP3 SPHK2 SPHK1 PMC7472175__F1 Schematic model for T-cell receptor signaling LAT HEXIM1 GRB2 PMC10932966__F3 Distribution of S1P is strictly controlled and involved in innate and adaptive immunity SPNS2 CD69 APC PMC6591247__F8 FOXP1-induced CLRN1-AS1 suppressed pituitary prolactinoma by acting as a ceRNA to regulate DKK1/Wnt/Beta-catenin pathway DKK1 PMC7287590__F3 Canonical aryl hydrocarbon receptor (AhR) activation pathway AIP AHR PMC7287590__F4 Proposed models of NLRP3 inflammasome inhibition via AhR pathway NLRP3 AHR IL1B PMC11872079__F8 Schematic model illustrates the role of Sirtuin 5 (SIRT5) in the regulation of follicular recruitment in chickens through its influence on the autophagy-lysosome pathway in granulosa cells (GCs) F5 F2 F3 SIRT5 PMC3754142__F3 Oncogenic and antiapoptotic functions of KSHV BAX SMAD2 ATM MDM2 SKP2 CDK4 PMC5738879__F9 Signaling pathway in the adhesion of stem cells to bone biomaterials PAK1 VTN CHAD SRC PMC9099768__F1 Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin STAT3 SOCS3 MTOR PMC5431132__F2 Endoplasmic reticulum‐associated degradation (ERAD) and unfolded protein responses (UPR) ATF4 EIF2A XBP1 PMC9128097__F1 Rhythm disturbance in osteoarthritis TNC DBP SMAD1 MMP14 PER2 NR1D1 PER1 SMAD2 CRY1 ADAMTS5 NAMPT COL2A1 ACAN SOX9 NR1D2 CRY2 SIRT1 IL1B PMC8524703__F1 Glioblastoma pharmacotherapy: A multifaceted perspective of conventional and emerging treatments (Review) EGFR PTEN CCM1 CDKN2B MTOR RB1 MDM4 CDKN2A CDK6 CDKN2C KLLN NF1 PDGFRA MDM2 CDK4 PMC7549271__F1 Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders UGT8 PMC5261002__F2 Gene network associated with ‘cell death and survival, DNA replication, recombination, and repair' in sPIF-treated EVT PLCD3 IFNG TNFSF14 BAX INHBA PAXIP1 BCL2 CECR2 NODAL GRN IL6 PMC12240642__F1 Ubiquitination‐mediated degradation of EGFR‐EGF complex and inhibition of downstream signalling in EGFR‐mutated cancer STAT3 EGF EGFR PMC3235907__F1 Clopidogrel activation and platelet aggregation pathways CYP1A2 VWF F2R ADCY3 F2 CYP3A4 PMC2575400__F2 MiRNA Signature of Prion Induced Neurodegeneration SRP19 DAZAP2 UBE2G1 KPNA3 ETV6 UBE2E3 CASP3 XBP1 CP PMC4072629__F3 VPA Alleviates Neurological Deficits and Restores Gene Expression in a Mouse Model of Rett Syndrome HRH3 PLCB4 PARVG NMB NTSR1 DNM3 SKP2 NFIL3 KCNA2 ASAH2 KCNA1 FOSL2 PAP SYNM VAMP1 COL4A2 CYP51A1 TAOK1 VAV3 CNTN1 SPATA24 MAGI1 STX1B CAMK2D HPGD EDNRB KCNC1 SLCO1A2 PMC9477374__F6 EA activated EPO mediated Src signaling pathway and VEGF signaling pathway to promote angiogenesis in CIRI rat brain tissue EPOR EPO SRC PMC3660836__F6 O-GlcNAcylation in FGF signaling OGA OGT PMC4249544__F3 Central carbon metabolism, including glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle MAL FOS CIT PMC4866030__F1 NFKB signaling pathway with genes associated with objective PNMS CD40 EGF TGFA TIRAP CARD11 RELB TAB3 GSK3B TANK PELI1 MYD88 NGF PLCG2 RELA PMC7312833__F6 Functional relationship between GFAP+ (glial fibrillary acidic protein) reactive astrocytes and IBA+ (ionized calcium-binding adapter molecule) activated microglia CXCR3 TREM2 HMGB1 GFAP HEL-S-62p TLR4 LCN2 CXCL10 PMC7312833__F5 Chemokine signaling pathway CXCR3 STAT3 GFAP CCR5 CCR2 LCN2 CXCL10 ITGB3 CCL2 PMC7312833__F2 Canonical and non-canonical inflammasome pathways GSDMD NLRP3 IL1B PMC7312833__F1 Toll-like receptors (TLRs) signaling pathway TBK1 IL1R1 HMGB1 TLR3 TLR4 IRF3 TRAF3 TRAF6 TNF IL1B PMC4586772__F1 Inhibitors have been developed for their ability to block Hh signaling at various signaling nodes in the pathway SUFU PTCH1 SMO PMC7312833__F4 Interleukin (IL)-6/Grp130-JAK-STAT signaling pathway STAT3 FOXO3A SMAD2 TGFBR3 SOCS3 TGFBR1 PMC7312833__F3 Tumor necrosis factor A (TNFA)/TNFR1 signaling pathway RIPK1 TRAF2 IL1B PMC4702912__F6 ‘Wnt Signaling pathway’ from KEGG () (ID hsa04310) SIAH1 ROCK2 APC LRP5 SMAD4 LRP6 ARHA CTNNB1 BAMBI RBX1 SOST CER1 SKP1 NLK DAAM1 PMC6966455__F8 Signaling pathway involved in GR cells with ROCK2 inhibition ROCK2 SP1 PMC3612035__F7 Non-Canonical CRL4A/4BCDT2 Interacts with RAD18 to Modulate Post Replication Repair and Cell Survival RAD18 ATR PCNA HLTF ATM CDT1 PMC4127377__F9 MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1 SOX9 MAF DEPTOR PMC5576693__F4 Study on molecular mechanism of ANOS1 promoting development of colorectal cancer DACT1 SFRP4 ANOS1 ROR2 CTHRC1 FZD1 DKK2 SMURF2 LEF1 HEL2 SFRP1 PMC7682230__F3 Hypoxia signaling pathway involves EGLN1-mediated hydroxylation and VHL-dependent ubiquitination of HIF-1A/2A subunits leading to its proteosomal degrardation under normoxic conditions EGLN1 IKZF1 SP1 HIF1A VHL PMC6235775__F4 Intracellular calcium regulates muscle atrophy via calpain regulated Ub-proteasome pathway and apoptosis BAX HEL-S-11 PMC3712188__F3 Autophagy and polyglutamine diseases BCL2 RAP2B INS PMC3712188__F2 Inducing autophagy by inhibiting the mTOR pathway.mTOR is a downstream effector of the class I phosphoinositol 3-kinase (PI3K) pathway RHEB MLST8 TSC2 TSC1 ULK1 PMC3966871__F3 High-Throughput Quantitative Proteomic Analysis of Dengue Virus Type 2 Infected A549 Cells VMA21 AURKA RBM22 TGFBI NDUFB11 TGOLN2 KIF20A MMADHC ASCC2 ATF2 CHCHD2 GLB1 FAM3A SRP54 AXL PITPNB SCD HEL103 UBE2S CNTN1 GCS1 LONP2 AURKB EIF3D GRAMD1A CASKIN2 TMEM165 POLR2D CDK2 EIF3B RRP36 CPSF2 PLP2 PSAP BAIAP2 PRPF39 NUP210 PRAF2 GOLPH2 ELF3 NRCAM P4HA2 IFIT3 BCAM IFIT2 LYZ FADS2 LAMC1 ERC1 HRBL SLMAP KLF16 SEC16A CLU ASPH APP ISG15 DHRS1 EEF1A2 CCNB1 TOP2A CDK4 JUN ECT2 DNAJB12 PEG10 HYOU1 RELA CREBBP PMC8293491__F6 Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease CXCR3 STAT3 SYK DKFZp781O1323 SHC1 PXN CCL3 NCF2 MCL1 GSK3B PIK3R1 GNG12 FLOT2 MAPK9 STAT1 PDPK1 OSMR NRAS HEL-S-1 PRKAR1A CREB1 EIF2AK2 ARHH CXCR6 HEL70 VAV1 NOTCH2 CXCL10 EIF4E PDHA1 TIAM1 MAP3K1 IGF1 IFNAR2 PAK1 AXIN1 BCL2 WASF2 GRB2 LMNA CXCL9 CXCL12 PYCARD THY1 ITGAV TBX21 PRKCB TGFBR1 TGFBR2 TFRC OLR1 EIF2S1 CCND2 CX3CR1 ITGA6 NFKBIE ACTG1 LCP2 EIF4EBP1 NFATC1 KRAS RBPJ EEA1 IGF2 GNG2 RUNX1 NFAT5 GNB4 LPIN1 STAT4 NFATC3 TNFSF10 PMC9465167__F1 Human immunodeficiency virus-1 core: The Trojan horse in virus–host interaction TBK1 CGAS IRF3 CPSF6 PMC4730296__F1 Outline of melatonin biosynthesis and function AANAT ME1 PMC8745614__F4A Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells EFNB2 RELB PTEN MAP3K14 CP PMC6095005__F3 Mechanisms involved in the induction of depressive symptoms in inflammatory conditions (gray arrows) and potential therapeutic implications following pharmacological or nutritional interventions (blue arrows) TH KMO PAH PMC6095005__F2 Inflammation-associated BH4 pathway TH DHFR PAH PMC4437198__F1 Genetic Variants in the Fibroblast Growth Factor Pathway as Potential Markers of Ovarian Cancer Risk, Therapeutic Response, and Clinical Outcome FGF7 FGFR1 FGFR2 PMC8204019__F1 Radiation Resistance: A Matter of Transcription Factors STAT3 STAT1 MUC1 PMC8293691__F2 Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target BAX SIRT3 CGAS FIS1 NLRP3 OPA1 MFN1 TLR9 MTOR PMC8226175__F1 Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy USP28 TRIM32 RNF4 ELL USP37 MYC HUWE1 UBR5 USP36 SPOP SENP1 USP22 FBXL16 RLIM PMC7563533__F2 Key databases as primary resources for drug repositioning HEL-S-29 PTH PMC3606591__F1 Novel approaches to inhibitor design for the p110B PI 3-kinase TEC PTEN RHO PMC3676754__F2A The Brassinosteroid Signaling Pathway—New Key Players and Interconnections with Other Signaling Networks Crucial for Plant Development and Stress Tolerance BIN2 BAK1 PMC1065305__F1 Components of the AhR-mediated lacZ reporter assay GAL AHR PMC10818625__F2 Pharmacological interventions against necroptosis in pneumonia RIPK3 FAS MLKL TLR4 RIPK1 PMC10818625__F1 Mechanism by which pathogenic infection causes cell necroptosis FAS TRADD MLKL TAB3 IRF1 RIPK3 STAT1 ZBP1 TLR3 TLR4 RIPK1 JAK1 TRAF2 FADD PMC6166407__F1 Pro-tumorigenic functions of GPNMB ECD EGFR NRP1 GPNMB ADAM10 SRC PMC11898298__F6 Ironomycin cytotoxic effects alone and in combination with other drugs BAX BTK BCR GPX4 CARD11 PMC6726297__F1 Cholesterol-dependent inflammatory response and cell death in the hepatocyte TG FAS ABCG8 ABCG5 IL1B PMC8705762__F3 Sperm-Guiding Unconventional Prostaglandins in C. elegans: Synthesis and Signaling SGK1 INS PMC4711336__F1 TGFB signaling and regulation BAMBI SMAD2 PMC4160341__F3 Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells CDC2 PAK1 ECT2 ARHGEF7 ARHA PMC4142219__F3 Characterization of glycoproteins in pancreatic cyst fluid using a high performance multiple lectin affinity chromatography platform CTRL PNLIP CCK CFTR ARHA RAC1 AMY2B PMC7346227__F2 Primary cilia control Hedgehog pathway output GPR161 SUFU PTCH1 SHH SMO MYC GLI3 PMC5429551__F2 The dual role of TGFB in tumor progression and its association with RAC1b and RAC1 expression SMAD2 RAC1 PMC9047778__F2 Providing a Helping Hand: Metabolic Regulation of T Follicular Helper Cells and Their Association With Disease ICOS CXCR5 MTOR BCL6 PMC8222406__F10 CSC-associated AKT/TSPYL5/PTEN loop signaling pathway CD44 ALDH1A3 TSPYL5 HEL-S-53e EGFR PTEN PMC3360606__F1 Integrative Gene Regulatory Network Analysis Reveals Light-Induced Regional Gene Expression Phase Shift Programs in the Mouse Suprachiasmatic Nucleus VIP NPAS2 JUN BRS3 NMBR CRY2 DUSP14 FOS AVP PMC8358691__F1 Physiological impact of in vivo stable isotope tracing on cancer metabolism GLS GC PC PMC8286839__F14 Recruitment of repressors leads to termination of transcriptional responses CRP CSA2 CITED2 NLK PMC2720262__F1 Summary of consequences on signal transduction and brain architecture of conditional Pten or Pdk1 deletion, alone or in combination RHEB TSC2 TSC1 GSK3A GSK3B RS1 PTEN MTOR EIF4E PMC11274695__F4 Protein interactions in plant hormone pathways confirmed using BiFC EHD2 ARF1 PTPA ARF5 EHD1 PMC11274695__F3 Interacting proteins in the classical cell signaling pathway validated using BiFC TMEM134 IL10 APC EMP3 FLOT1 HTATIP2 MYC TRAF6 FOS CTNNB1 MYD88 CDKN2A RAP2A ATG3 BATF3 AJUBA PLP2 CACYBP CCND1 PMC6078990__F1 YAP regulates innate antiviral immunity via a transcription-independent mechanism LATS1 TBK1 LATS2 CGAS MAVS TEAD2 TEAD3 IRF3 TEAD4 PMC6025041__F4 Metabolic pathways influenced by transcriptional factor O-GlcNAcylation OGA OGT FAS SP1 PMC11825788__F2 Neuropeptides released from nerve endings and receptors on GCs are illustrated VIP MUC5AC CALCRL TRPM5 EGFR TRPV1 FOXA3 FOXA2 SPDEF TRPM8 PMC6690701__F8 Several H2S-sensitive metabolite changes map to redox active nodes in central carbon metabolism HEL-S-162eP MAL PMC4870087__F7 Dominant-negative GA subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease PLCB4 DLX6 DLX5 PMC6025041__F3 HBP modulates cancer metabolism through the O-GlcNAcylation OPA1 HEL-S-162eP FASN HEL-S-30 PMC8175487__F8 Nobiletin enhances the development and quality of bovine embryos in vitro during two key periods of embryonic genome activation H3F3B NR1C1 CDK2 GRB2 GPX1 PMC8323274__F6 NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway STAT3 NR1D1 SOCS3 PMC6025041__F1 Hexosamine biosynthesis pathway OGA OGT PGM3 NAGK PMC4693901__F2 Protein kinase C (PKC) involvement in cytoplasmic signal transduction pathways in the immune system TBK1 TIRAP APC IRF3 IRF7 IL6 TRAF6 MYD88 IFNG PLCG1 BCL10 BCR TLR4 PMC6248440__F2 Schematic representation of miRNA (left) and piRNA (right) biogenesis RAN DGCR8 DROSHA PMC3180046__F2 NFKB signaling pathways CD40 LTBR PDLIM2 RELB IRAK1 TRAF3 TRAF6 IRAK4 MAP3K7IP1 BCL10 BCR RELA TRAF2 CYLD PMC8943305__F8 Clinical and Apoptotic Factors Defining and Predicting Steroid Resistance in Nephrotic Syndrome in Children BAX BCL2 HP PMC10816282__F7 Proposed scheme for transcriptome stress response to APS JUN EIF2A FOS PMC10745077__F6 Pro-apoptotic Bax-induced release of cytochrome stimulates the caspase signaling pathway in the mitochondria, resulting in enhanced hepatic cell apoptosis BAX CASP9 CASP3 PMC10816282__F6 Transcription response to APS of the JNK/MAPK (A), JAK/STAT (B), Toll and Imd (C) signaling pathway genes in the control and GagrRNAi females and males FAS PMC11529284__F3 Sodium taurocholate co-transporting polypeptide expression FGF8A NR2A1 FGFR4 SIRT1 PMC5979829__F8 LIF and the PI3K/Akt signaling pathway LIF TBX3 PMC5750128__F7 Schematic drawing showing the effects of IGF-1 and ALC on prepubertal Kp synthesis and release RHEB TSC2 IGF1 RS1 IGF1R MTOR IRS1 PMC8674954__F8 Committed Human CD23-Negative Light-Zone Germinal Center B Cells Delineate Transcriptional Program Supporting Plasma Cell Differentiation CD40 BCR PRDM1 GC CR2 PC IL21R CR1 PMC4413635__F1 Cyclin alterations in diverse cancers: outcome and co-amplification network RB1 CDKN2A CDK6 ERBB2 CDK2 CDKN2B MTOR CDK4 PMC8889522__F2 An insight into the mechanisms of COVID-19, SARS-CoV2 infection severity concerning Beta-cell survival and cardiovascular conditions in diabetic patients TMPRSS2 ADAM17 ACE2 PMC11995161__F2 Role and regulatory mechanism of LAPTM4B in tumors RHEB LAPTM4B CDK12 NEDD4 EGFR TFEB SLC39A2 ATG5 PMC8235525__F2 Metabolic Choreography of Maize Plants Treated with a Humic Substance-Based Biostimulant under Normal and Starved Conditions HEL-S-62p MAL IMPACT PMC3195649__F2 Targeted therapies for breast cancer RHEB PTEN PMC5893285__F3 Involvement of miR-126 targetome in focal adhesion signaling pathway from KEGG is shown JUN BAD FYN PTEN SHE PMC5893285__F2 miR-126 is involved in neurotrophin signaling pathway pathways including IRS1, PI3K and IKB, which their partial diagram collected from KEGG pathway is demonstrated BAD RAE1 FES HEL-S-11 TRAF6 DAO IRS1 PMC10552782__F2 Regulatory Mechanism of Iguratimod on Signaling Pathway (IFN, interferon; TNF, Tumor necrosis factor; IL, Interleukin; Th, helper T cells; Treg, Regulatory T cells) IFNG JUN EGR1 IL6 DLX5 TNF PMC3948174__F1 Regulation of G protein-mediated signaling by RGS2 in the heart RGS2 PGC GCA PMC6328940__EV1 B‐RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice COQ8B COQ10A COQ7 COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 PMC7747191__F2 Toll-like receptor signalling in B cells during systemic lupus erythematosus IFNG BCR CXCR5 TLR7 LAG3 PMC11904754__F6 GALNT proteins involved in lung cancer and pathway related GALNT3 GALNT1 GALNT4 GALNT6 PMC11904754__F5 The GALNT14 protein regulates the occurrence and development of lung cancer PCDH7 LAMC2 SMAD2 APC SMAD4 CTNNB1 PMC9009290__F9 Chrysin Ameliorates Influenza Virus Infection in the Upper Airways by Repressing Virus-Induced Cell Cycle Arrest and Mitochondria-Dependent Apoptosis BAX CDK2 CDK4 PMC3849657__F1 YAP/TAZ are effectors of mechanical stress, GPCR signaling, and the Wnt signaling pathway. Mechanisms of YAP and TAZ regulation by mechanical stress, GPCR signaling, and the Wnt pathway as well as YAP/TAZ as modulators of the Wnt pathway are shown LATS1 LPA BIRC5 BCL2L1 LATS2 YES1 SOX2 RHO TBX5 AREG ASCL2 CTNNB1 PMC2948275__F1 Putative functions of caspase-2 CDC2 BAX ATR ATM CCNB1 PMC2100434__F2 Growth hormone-mediated JAK/STAT signal transduction SOCS2 GHR PMC9318484__F2 Natural Products and Their Multitargeted Approach to Treat Solid Cancer RHEB TSC2 BAD TSC1 FOXO1 PTEN MTOR IRS1 EIF4E PMC4196962__F6 Interleukin-1B Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes PTCH1 SHH SMO CXCL2 CCL2 CCL20 IL1B PMC7211213__F3 Therapeutic targets associated with activation of the Wnt signaling pathway TF APC GPR49 CTNNB1 PMC7643360__F5 Summarized diagram proposing that IGFBPs secreting PD-MSCsPRL-1 are the key antiadipogenic factors inhibiting adipogenesis in OFs from GO patients through upregulation of FAK and downregulation of the PI3K/AKT/mTOR signaling pathway PTEN DEPTOR IRS1 PMC6813133__F3 ADHD gene-networks constructed with PASCAL associated genes and its FunCoup interactors GMNN AURKA TCP1 MED4 ANAPC2 PMC6088210__F1 TLRs mediated the T cells response and programmed cell death process toward tumor environment TH TBK1 CD80 TRADD TIRAP IRF3 TRAF6 FOS FADD MYD88 PMC7760785__F2 Crosstalk between the major signaling pathway regulating autophagy and liver tumorigenesis RHEB TSC2 TSC1 ULK1 APC GSK3B BNIP3 PTEN TNF DEPTOR PMC2667769__F5 Defective respiration of Δisc1 in the post-diauxic phase COX2 ATP6 CIT PMC5445208__F6 Genes involved in B-cell receptor signaling which converges to mitogen-activated protein (MAP) kinase pathway, nuclear factor KB (NFKB) pathway, and phosphoinositide 3-kinase (PI3K) pathway are the therapeutic targets of B-cell lymphomas CD79B SYK CD79A BTK BCL10 PI3 CARD11 MTOR PMC8350857__F2 Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research EGFR HSF1 GSK3B SESN3 EPO BNIP3 GATA6 MTOR CTNNB1 PMC5161407__F4 Nuclear DNA damage signalling to mitochondria in ageing BAX CASP9 BAD FAS PINK1 CASP8 ULK1 DRAM1 ATG101 TSC2 CASP3 ATM APAF1 SIRT1 FADD PMC7211213__F1 Simplified overview of canonical Wnt signaling pathway activation APC GSK3B CTNNB1 PMC6586148__F6 SHP2–ERK1/2 inhibition and STAT3 activation by Sunitinib MYOG ITGA7 PMC6190667__F8 Carbon contribution of medium ingredients to riboflavin based on combined parallel 13C-labeled tracer studies using [13C2] glycine, [13C] formate, [13C5] glutamate, and [U13C] yeast extract MAL GIP FAP PMC8833570__F1 KRAS and RAS-MAPK Pathway Deregulation in Mature B Cell Lymphoproliferative Disorders SYK CD79B CD79A BLNK CD19 MTOR BTK BCR PLCG2 NF1 LYN MDM2 GRB2 PMC3328893__F1 Physiological and pathophysiological stimuli regulate tonicity-responsive enhanced binding protein (TonEBP) in diverse cell types IL16 BMP2 PMC7484670__F6 MTOR-miR-143 signaling axis in the pathogenesis of AD IL13RA1 FLG IVL PMC4026357__F1 Importance of Breast Cancer Subtype in the Development of Androgen Receptor Directed Therapy ERBB3 CTNNB1 PMC8850641__F9 Identification of Potential Blind-Side Hypermelanosis-Related lncRNA–miRNA–mRNA Regulatory Network in a Flatfish Species, Chinese Tongue Sole (Cynoglossus semilaevis) DCT TYRP1 PMC8137895__F1 Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases RAN DGCR8 AGO2 DROSHA PMC6457262__F1 Galantamine-memantine combination superior to donepezil-memantine combination in Alzheimer’s disease: critical dissection with an emphasis on kynurenic acid and mismatch negativity HEL-S-90n KMO PMC6611005__F9 Anti-pancreatic cancer pathway of Wumei Pill EGF BAD TRADD EGFR HIF1A MYC TRAF6 IKBKG MYD88 BCL2L1 CHUK KDR MDM2 CASP9 JUN PTGS2 TNF NFKB1 RELA IKBKB CASP3 NFKBIA CDK2 BCL2 GRB2 TRAF2 FADD PMC5233600__F1 NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection NLRP3 IL16 AIM2 IRAK4 MYD88 PMC8966686__F10 Integrative Transcriptomics and Proteomics Analysis Provide a Deep Insight Into Bovine Viral Diarrhea Virus-Host Interactions During BVDV Infection IFNE JUN MAVS SCD FASN DHCR24 IRF3 IRF7 MTOR IL6 TRAF3 TRAF6 IFNG IFNK SERP2 CASP6 NLRP3 CASP3 MAP3K7 DHCR7 MAP2K3 CASP10 FADD PMC3744088__F6 Extent to which glutamate (GLU) is oxidized in astrocytes seems to increase particularly during higher glutamate concentrations MAL PC CIT PMC12188105__F1 Glutamine signaling pathway and metabolism in cancer GLUD1 GOT2 GLS GPT2 TFEB SLC7A11 MYC KRAS HEL-S-26 PMC6886699__F9 Adenoviral Transduction of EGFR into Pregnancy-Adapted Uterine Artery Endothelial Cells Remaps Growth Factor Induction of Endothelial Dysfunction EGF EGFR GRB2 VEGFA SRC TRPC3 PMC7374824__F1 TLR signaling TLR1 TLR3 TIRAP TLR4 TLR9 TLR8 TLR5 IRF3 IRF7 TLR7 MYD88 PMC2311275__F4 Following biological functions (central carbon pathway, redox and respiration coordination, phosphate starvation, nitrogen gestion, carbohydrates, nucleotide and amino acids metabolism, ribosome activity) CAST MAL PC HAMP COPA CIT PMC12188105__F4 Targeting glutamine metabolic reprogramming in cancers GOT2 EGFR GPT2 SIRT4 SLC38A1 SLC7A11 MTOR SLC7A5 MYC KRAS EGLN1 PIG59 FOXO3A PMC12188105__F2 LncRNAs regulate glutamine metabolism in cancer GLS HIF1A ATF4 TUG1 PMC6504851__F2 Diagram showing differentially expressed genes in BXW-resistant and BXW-susceptible genotypes of banana after inoculation with Xanthomonas campestris pv MYB ERF FER MSC PTEN PMC3261702__F4 Structural coverage of the core vision pathway and its links to other functional modules ART3 RCVRN RGS9BP GAP43 PRKD1 PDE6D ARF6 CNGA1 ACTN2 RHO TUBA1B PRKCB CAMK2A RALB MYL1 RALA TUBA4A GC ARL1 ACTN1 MYH10 MYH1 TUBB KRAS TUBA1C SAG ACTN4 PDC RP2 GRK1 RAB13 ARF4 MAP2K1 SPTAN1 PMC5821407__F4 Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic- and oxidative stress-related diseases ACO2 HK2 NDUFV2 NDUFA7 COX5A LDHB NDUFS8 GPX3 CS HEL-S-97n HEL-S-30 UQCRC1 PGAM1 SDHB HEL-S-128m NDUFB7 HEL-S-87p COX6B1 HEL-S-44 PMC37430__F1 Simplified steps of Okazaki fragment maturation during DNA lagging strand synthesis (for further details see refs RAD52 DNA2 PMC8894711__F2 Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection CGAS STAT2 CCND1 CTNNB1 PMC8894711__F1 Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection CASP8 TIRAP PDC IRAK1 IRF3 TRAF6 RAC1 IRAK4 FADD MYD88 PMC12123228__F2 Proposed mechanisms of BTKi-induced hypertension CD40 BTK ARHA NOTCH1 PMC3973006__F8 Schematic model of TGFB signaling pathways for CRP2 induction in VSMCs CSRP2 SMAD2 SMAD4 ATF2 ARHA PMC12123228__F1 BCR signaling pathway and mechanism of action of BTKi SYK BTK BCR PLCG2 BLNK CD19 LYN MTOR PMC5952256__F1 The mechanism of extracellular vesicles (EVs) release differs among different types of EV LIMK1 ARF6 PMC3469596__F8 Neutral lipid and phospholipid biosynthetic pathways LPA TG PLIN1 LDLR PC PMC8375160__F10 Mutual regulation between chicken telomerase reverse transcriptase and the Wnt/Beta-catenin signalling pathway inhibits apoptosis and promotes the replication of ALV-J in LMH cells BAX TCF4 CTNNB1 PMC7167271__F11 Effect of RPMP and emodin on genes expression profiles TG ACOX1 PMC5584530__F8 Cell surface HSPGs consists of a protein core linking several linear heparan sulfate (HS) chains CDK8 APC LRP6 CTGF CTNNB1 PMC2921605__F1 PIK3/Akt/mTOR Pathway PTEN MTOR EIF4E PMC3022184__F2 A proposed mechanism of TGFA/EGFR/ras-MAPK activation loop in HNSCC CBL TGFA EGFR PMC7307792__F4 Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei PRODH PMC7564912__F8 Diagram indicating the mechanism of IITZ-01-induced TRAIL sensitization CBL USP9X FADD PMC6082928__F3 LMP1 in the carcinogenesis of nasopharyngeal carcinomas STAT3 CSA2 EGFR JAK3 ATM PMC11829765__F8 Lineage diversification in the ureteric mesenchyme BMP4 SHH MYOCD ALDH1A2 WNT7B PMC8889569__F4 Phosphatidylcholine-Derived Lipid Mediators: The Crosstalk Between Cancer Cells and Immune Cells LPA LPAR4 KPG_010 LPAR2 LPAR1 MTOR LPAR3 PMC6082928__F6 Signaling pathways engaged by the LMP2A gene BCR GSK3B CTNNB1 PMC4766172__F1 Lysine degradation pathways in mammals GCDH ECHS1 DHTKD1 PIPOX AADAT AASS PMC6191511__F1 Functional analysis of genes differentially expressed in response to L-lactate after 1 h MAX TH MAK NFKB1 MAPK7 EVI1 CREB1 CA14 PMC6530608__F1 Mitochondria and ER in activation of the NLRP3 inflammasome NLRP3 AIM2 CMPK2 PMC3617401__F2 Emerging actions of the nuclear receptor LRH-1 in the gut CCNE1 TCF4 CCND1 CTNNB1 PMC9195630__F10 Long Non-Coding RNA TMPO-AS1 Promotes GLUT1-Mediated Glycolysis and Paclitaxel Resistance in Endometrial Cancer Cells by Interacting With miR-140 and miR-143 MMP14 HK2 PMC5839790__F1 Classic autophagy compared with related trafficking pathways SNAP23 HMGB1 KIAA0226 ULK1 SNAP29 UVRAG ATG14 STX17 VAMP8 SEC22B ATG3 IL16 STX4A STX3A ATG5 ULK2 PMC2992267__F8 A schematic model showing the proposed biosynthetic pathway for cutin LPA GPAT4 PMC6912224__F2 SMAD- and Non-SMAD-dependent TGFB signaling TF RHO MTOR PMC11855511__F8 Construction of DEmiRNA-mRNA expression regulatory network based on JAK-STAT signaling pathway and phagosome XK PMC7864954__F6 miR156-based regulation of SPL13 enhances photosynthesis, phenylpropanoid, and ABA biosynthesis in response to flooding GCG MYB PC PMC7919044__F2 G protein-coupled receptor (GPCR) kinase 5 (GRK5) activities within cardiomyocytes, cancer, and neuronal cells EGF HBEGF EGFR BCL2 NFATC3 SRC HDAC6 PMC5811627__F1 Outline of main altered pathways in pancreatic neuroendocrine tumours KMT2C EWSR1 PSPN RAD51 BRCA2 PTEN MTOR SETD2 VHL TSC2 FLI1 TSC1 BRCA1 MUTYH MEN1 CHEK2 ARID2 DEPDC5 PALB2 SMARCA4 PMC4415242__F8 The three axes of the UPR in Drosophila brains activated by HTorAΔE ATF4 EIF2A XBP1 PMC4234565__F3 Circadian pathways ERBB4 DTX4 PIK3R1 IL7R IGF1R CD19 MTOR VEGFA ERBB3 IGF1 ERBB2 FLT1 KDR PMC8072385__F2 Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein HMGB1 CD24 MTOR REL ATG5 PMC9320351__F3 Vitamin D Derivatives in Acute Myeloid Leukemia: The Matter of Selecting the Right Targets NR1i1 CYP24A1 RXRA PMC5362547__F2A Hippo signaling pathway provides novel anti-cancer drug targets LATS1 MOB1A MOBKL1A LATS2 AMOT RHO NF2 PMC8909913__F1 Cancer-Associated Fibroblasts: Mechanisms of Tumor Progression and Novel Therapeutic Targets SMAD1 AFP PATJ AMOT APC SOX2 SMAD4 CTNNB1 PMC7456423__F6 Squalene synthase promotes the invasion of lung cancer cells via the osteopontin/ERK pathway SRC SKI PMC3720596__F1 NRAS mutant melanoma – undrugable? CDKN2A NRAS MTOR CCND1 PMC6346552__F9 Proposed molecular model of non-coding RNAs involved in CXCL12/CXCR4-induced CRC invasion and progression CXCL12 RHO CXCR4 PMC9204587__F1 Cholesterol and Its Derivatives: Multifaceted Players in Breast Cancer Progression HMGCR FDPS ABCA1 PMC8533474__F5 Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet FAS GPX4 LOC51064 HEL-S-51e GPX1 SLC27A5 ACSS2 MPV17L ALDH2 LCT HEL-S-182mP MCCC2 BCAT2 PRDX5 MTHFD1L GPT MTHFD2 GPT2 CTH ACOT8 ACSS3 ACSM5 SLC6A12 MTHFD1 ACSM3 PHGDH BHMT2 PRODH PMC7577395__F2 Representative contributions of ion channels to glioma cell proliferation TRPM7 MTOR PMC6592760__F2 Metabolic regulation of cell growth and proliferation RHEB PHGDH PSAT1 ATF4 ASNS PMC9009531__F1 Lipid Metabolic Process Involved in Oocyte Maturation During Folliculogenesis ACSL3 ACSM3 HEL-S-5 FACL4 CPT2 PMC8063501__F2 DSB repair pathway choice SHLD1 RAD52 RAD51 LIG1 BRCA1 PAXX BRCA2 RIF1 POLE SHLD3 PARP1 SHLD2 PMC11357158__F2 TGFB1/Smad pathway mediated by identified ncRNAs COL1A1 TUBD1 FSTL1 SMAD2 LEFTY2 SMAD4 PMC11357158__F1 Biological pathways and interactions of three ncRNAs DGCR8 DROSHA PMC3267157__F2 P73 pathway and its regulators.A simplified view of the p73 pathway, of its regulators, and of the molecules that directly or indirectly can modulate its function TSC2 TSC1 ITCH ATM MDM2 MTOR PIN1 PRIMA1 PMC11357158__F3 Hippo and Hedgehog pathways mediated by identified ncRNAs LATS1 ADRBK1 MOB1A FBXW7 KIF7 TEAD2 TEAD3 SUFU PTCH1 SMO TEAD4 PMC4232283__F8 Proposed working model NT5E ENTPD1 PMC11357158__F5 Wnt/Beta-catenin pathway and associated ncRNAs APC LRP5 LRP6 PMC9100112__F9 Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer through H19 Long Non-Coding RNA Expression STAT3 LIF PMC3498840__F1 TLR signaling overview: the TLR family can be subdivided into two categories TLR1 TIRAP TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 IRF7 TLR7 MYD88 PMC12013188__F14 Signaling pathways regulating the HAG STAT3 BAX CSA2 KEAP1 MMP10 EGFR TNF TRAF6 MYD88 HBEGF ADAM17 NLRP3 TLR4 NOD1 PMC4993044__F3 Proposed sequence of events following aberrant fatty acid reabsorption at the apical surface of the proximal tubule in the setting of nephrotic syndrome ALB TG ACSL1 CPT1A PMC2522278__F2 Comparative Analysis of mRNA Targets for Human PUF-Family Proteins Suggests Extensive Interaction with the miRNA Regulatory System CDC42 MAPK1 EGF JUN RHOF SHC1 EGFR APC TCF4 ATF2 RAC1 CTNNB1 ARAF STAT1 EFNB1 EXOC2 GSK3A SIAH2 RHOB FGFR1 AXIN1 FLT1 GRB2 PMC2682371__F2 ErbB proteins are type I transmembrane receptor tyrosine kinases ERBB3 STAT3 SOST ERBB4 EGFR AK1 MTOR SRC MYC FOS PMC8712868__F2 Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases RHEB TSC2 FOXO1 MTOR MFF RUNX2 FGF18 IL1B PMC4889588__F1 Schematic depiction of oncogenic MYC signal transduction MAX JUN PTEN MTOR MYC FOS EIF4E PMC4591983__F6 Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula NR1H4 STAT3 STAT1 IL1RAPL2 SCG2 COX2 PRL TFAP2A GRIN1 PMC4936107__F1 (Left) Model for sulfur assimilation CBL FES PMC4591983__F5 Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula FAT10 EPCAM BIRC5 DNAJB7 IL16 INSL4 HAND1 MAP3K14 TNF NPRC PMC4432002__F2 Role of the BM niche in MM pathogenesis CXCL12 TGFA BPI IL4 POLI CCL2 PMC4049967__F1 IL-15 and IL-17F are differentially regulated and expressed in mycosis fungoides (MF) STAT3 JAK3 IL17A PMC6816428__F1 Crosstalk between the Hippo pathway and Multi-vulval class B (MuvB) complexes LATS2 DYRK1A E2F4 PMC8817131__F3 PGC‐1A protects from myocardial ischaemia‐reperfusion injury by regulating mitonuclear communication NQO1 NRF1 POLRMT PMC3991464__F1 Four pathways of androgen metabolism CYP17A1 AKR1C2 PMC5789791__F1 Quantitative Proteomic Profiling Reveals Hepatic Lipogenesis and Liver X Receptor Activation in the PANDER Transgenic Model TG SCX PMC8105286__F1 Biophysics of Notch Signaling EGF C2 ADAM10 RBPJ PMC6436556__F3 A model showing how the cargo in exosomes can potentially change SYT7 EGFR RAB35 PMC9255252__F1 Characteristics of leukemic stem cells in acute leukemia and potential targeted therapies for their specific eradication SUFU APC JAK1 PMC8036803__F2 Msi1 impact on cell cycle and division HEL164 AURKA POLD3 RCC1 UBE2C BUB1B NCAPG TUBB4B STAG1 SMC3 SMAD2 SMAD4 ORC1L MYT1 CCNA2 SKP2 FANCD2 BIRC5 CDCA5 E2F4 RPA3 FGFR1 WDR76 SPC24 MDM2 SMC4 TOPBP1 MSH6 ESPL1 TIMELESS APC EZH2 SMC1A PRIM1 RBBP8 POLA1 POLA2 BRCA1 CDC45 CDK2 MCM2 SUV39H1 CDC25B CDK5RAP2 STAG2 TP73 CABL1 CDC20 PCNA NCAPD3 ORC6 CDC6 DCLRE1B BRCA2 CLSPN CENPE CDT1 TUBA1B BLM MSI1 DNA2 CDK7 C13orf34 TUBB2A PRC1 TOP2A DBF4 CDC2 FEN1 E2F2 CRY1 RRM2 KIF18B CBX3 ESCO2 ORC3 ORC2 RPA1 MAD2L1 RBL1 CCNE2 ATAD5 NUSAP1 PRKDC IPO5 INCENP CHEK1 WDHD1 RFC3 PMC7923925__F1 The Hippo Pathway in Breast Cancer Carcinogenesis, Prognosis, and Treatment: A Systematic Review AXL TEAD2 TEAD3 AJUBA NF2 MARK1 MYC CCND1 TEAD4 PMC8807040__F8 Liensinine Inhibits Osteosarcoma Growth by ROS-Mediated Suppression of the JAK2/STAT3 Signaling Pathway STAT3 BAX CDK6 CDK4 PMC5620328__F1 Long non-coding RNAs associated with non-small cell lung cancer EGF EGFR MTOR PMC8378993__F1 Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine storm STAT3 CNTF OSM LIF IL11 PMC9558278__F2 Identification of key gene networks controlling polysaccharide accumulation in different tissues of Polygonatum cyrtonema Hua by integrating metabolic phenotypes and gene expression profiles UGDH GMDS PMC5346727__F3 Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method TF JUND NFATC2 EGFR PIK3R2 PPP3R1 PPP3CA MAP4K2 IKBKG CYLD JUN ADM MAPKAPK2 FOS EIF4E HRAS CRK CAPNS1 CAMK2D HEL-S-69p HEL-S-102 DDIT3 HDAC9 MAP3K5 MAP2K1 CAMK2G CDC25B PMC1905373__F7 Mechanism of complement-dependent haemolysis via the lectin pathway: role of the complement regulatory proteins HEL-S-62p C2 C1S PMC10816532__F3 Potential mechanisms underlying the inhibitory effects of magnesium on vascular calcification CASR TRPM7 CTNNB1 PMC7432830__F4 HSP90 involvement in TGFB signaling cascade SMAD2 SMAD4 PMC5346727__F5 Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method TF STAT3 PANK1 NFKB2 TNFRSF1A NEK2 IL3RA MYC IKBKG MAP3K2 E2F4 GADD45B CYLD IL1B JUN SMAD6 IL7R FOS GDF6 HRAS CAPNS1 NFKB1 IFNAR1 GATA4 TRAF2 CDC25B PMC5346727__F4 Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method TF JUND PANK1 NFATC2 TNFRSF1A NEK2 PPP3CA MAP4K2 MYC IKBKG E2F4 CYLD JUN ADM MAPKAPK2 SMAD6 GDF6 HRAS CAPNS1 NFKB1 RAP1A HEL-S-102 DDIT3 HDAC9 GATA4 TRAF2 CDC25B PMC9355870__F7 SLC35B2 is a vulnerability in YAP1-driven MAPKi-resistant, BRAF mutant melanoma ERBB3 NRG1 HBEGF AXL EGFR SLC35B2 YAP1 PMC11748510__F10 Scheme summarizing the inhibitory effect of baicalein on PRRSV infection EGFR GP5 SRC PMC7902093__F3 Environmental mechanisms of orofacial clefts BAX BMP2 CASP3 SHH GATA6 FGF10 CTNNB1 PMC2731267__F1 Some putative molecular mechanisms that underlie the antineoplastic activity of mesalazine EGFR APC PMC7902093__F2 Environmental mechanisms of orofacial clefts TGFA tmp_locus_29 AIP AHR AHRR SRC RUNX2 NR3C1 PMC2912554__F6 Tumor suppressor pathways control Mdm2 function CDK6 SMAD2 MDM2 CDK4 PMC7902093__F1 Environmental mechanisms of orofacial clefts MSX1 AHR NOTCH2 NOTCH1 MSX2 LHX8 PMC5501134__F5 Complex and context dependent functions of the Slit/Robo signaling in angiogenesis SLIT2 ARF6 RHO ROBO1 SRC RAC1 ROBO4 PMC6002803__F1 Reciprocal Signaling Between Translational Control Pathways and Synaptic Proteins in Autism Spectrum Disorders RHEB TSC2 EIF4B TSC1 PTEN PMC9421970__F2 microRNA expression in acute myeloid leukaemia: New targets for therapy? TET2 FAS MAP3K10 MCL1 SOCS2 E2F7 PTEN MTOR FBXW7 CTDSPL CDK6 CCND2 ERRFI1 F3 NRAS MEIS1 ATL1 MAPK1 HMGB1 GATA1 DICER1 CAMKK1 SPRED1 FOXO1 HOXA9 FOXO3A KLF5 MAP2K1 BAK1 SIRT1 YWHAZ PMC6320978__F1 Schematic overview of the Nucleotide Excision Repair (NER) pathway ERCC1 XPA PCNA PMC6405523__F4 IIP-effectors in FOXJ1 regulatory network and their probable ciliary associations PARD6A CEP164 OGT SKIL TRIM32 EXOC4 INTU GSK3B PRKCZ ACD SOCS3 MYC SKP2 FLNA MAPK14 MAP3K2 TRAPPC9 HTT BBS2 FOXJ1 TINF2 NME7 SP1 APOE APC DLG4 DAB1 TERF2IP PARD3 PRPF31 ATXN1 GRB2 BAIAP2 CP VDAC3 CDC42 DYNLL2 TBK1 ATXN10 DNAAF19 CDC20 HEY2 FBF1 MEOX2 FAM161A ACTN2 RHO VCP IKBKG CTNNB1 BTRC PACRG TOPORS CEP128 APP EEF1A1 POT1 BIRC3 UBC TERF1 VHL FKBP5 RIPK3 IFT57 STOM RELA BBS4 SKP1 EP300 BIRC2 NLGN3 NPHP3 FADD PMC6317572__F2 Common downstream targets for cancers of the breast (blue dots), colon (green dots), lung (red dots), and prostate (brown dots) CDKN2A ATR CDK6 CDKN1A CDKN1B GSK3B SMAD4 CDK2 ATM CDKN2B SKP2 CDK4 PMC4089452__F2 Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease TSC2 TSC1 GSK3B PTEN SRC MYC SIRT1 CTNNB1 PMC4003878__F2 GSK3B and the control of infectious bacterial diseases JAK3 GSK3B TNF CTNNB1 PMC7911491__F3 Effects of squalene in the NF-ƙB pathway CD14 IL1B MYD88 PMC9575701__F3 An emerging role for cellular crosstalk in the cancer stem cell niche SMAD2 IL33 SMAD4 PMC3836174__F5 Hallmarks of Aging IGF1 PTEN MTOR SIRT1 PMC9575701__F1 An emerging role for cellular crosstalk in the cancer stem cell niche TEC IL1R1 TNC LIF NRP1 HEL-S-28 PTGS2 FOXP3 VEGFA PMC8813987__F9 Pathway that signal prolonged cutaneous allodynia elicited by CGRP released and associated with neurogenic inflammation TRPA1 RAMP1 TRPV1 PMC7288655__F9 TGFB signaling pathway BAMBI IFNG FST FRK SMAD4 SKP1 NODAL ARHA PITX2 HFE2 TGFBR1 PMC9549367__F1 Irisin in physiology and pathology BMPR2 TIMP3 GDF8 TIMP1 NLRP3 ADAM10 PMC3541267__F3 Signaling pathways driving mesenchymal stem cells to differentiate into lineages found in reparative disorders WNT10B WNT5B RYK CTNNB1 TGFBR1 PMC6774117__F10 NGF-driven differentiation of PC12 cells requires a signal(s) generated from the UPAR immediate-early gene product NGF EGR1 PC PMC4346319__F2 HIF Transcription Factors, Inflammation, and Immunity IFNG NOS2 SEMA3A IL6 PMC5161754__F7 EGFR activation during CRC progression through demethylation and subsequent upregulation of EREG at the adenoma–carcinoma transition EREG EGFR APC KRAS PMC10671577__F3 MAPK signaling pathway containing T MAX ECSIT EGF FAS EGFR AKT3 BRAF CD14 TNF MOS PDGFRA FGF9 TOB2 CHUK GRB2 TRAF2 CDC25B PMC7917723__F1 Absorption, and excretion pathway of gut-derived uremic toxins SULT1A1 CYP2E1 HEL-S-70p PMC9313309__F2 Mouse Models for Application in Colorectal Cancer: Understanding the Pathogenesis and Relevance to the Human Condition STAT3 S1PR1 COX2 APC SPHK1 KRAS CTNNB1 PMC5991449__F3 Overview of the pathways involved in odd and even fatty acid production including the link with the TCA and methyl citrate cycles in Yarrowia lipolytica HEL60 FAS ACO2 PMC7586293__F2 |Central metabolic pathways are driven not only by post-transcriptional changes but also by the adaptation of protein concentration upon the induction of insulin resistance RHEB RPTOR FOXD1 FAS FH ACO2 OGDH GSK3B PTPN1 MTOR ACACA SH2B2 PMC6476316__F4 Mutations in the bone morphogenetic protein-signaling pathway are linked to hereditary hemorrhagic telangiectasia and pulmonary artery hypertension BMPR2 SMAD9 ENG SMAD4 ACVRL1 DROSHA PMC10313365__F8 Roadmap of molecular changes and cellular phenotypes when cells lose MLL3/4-COMPASS DPY30 NCOA6 ASH2L WDR5 PMC11012155__F1 Endocrine Disruption Chemical-Regulated Aryl Hydrocarbon Receptor Activity in the Pathogenesis of Pancreatic Diseases and Cancer KLF6 AIP AHR CYP1B1 CYP1A1 PMC8499523__F6 Transcriptomic analysis of the seminal vesicle response to the reproductive toxicant acrylamide CXCL9 GATA2 TRAF3IP2 HMMR NXPE2 ECRG4 CCNA2 IKBKG CTNNB1 POR IFNG CACNA1H CCL21 F2R CD93 AHR CDKN3 FBN1 P2RX4 CSF2 EGR1 RPSA PLAUR CXCL10 SUSD2 S1PR1 TCF3 ITGB1 SERPINE2 IDO1 PRKAA2 NFKBIA ADFP IFI27 CCL8 EGR2 HLA-A DEFA3 PMC4419739__F4 Cellular and signaling pathway view of gene expression changes during alcohol withdrawal JUN ME1 PMC3267732__F4 Deeply Branching Thermophilic Bacterium with an Ancient Acetyl-CoA Pathway Dominates a Subsurface Ecosystem POR HEL107 RPE PMC3912487__F1 The sphingolipid rheostat in AD context HDAC1 IGF1 SPHK2 SPHK1 BACE1 HDAC2 PMC8072960__F3 Androgens and Androgen Receptor in Human Bladder Cancer SRD5A2 CXCR1 MMP3 IL8RB EIF4E PMC8072960__F1 Androgens and Androgen Receptor in Human Bladder Cancer SRD5A2 SHBG PMC12024137__F4 Research Progress on Hypoglycemic Effects and Molecular Mechanisms of Flavonoids: A Review EGR1 ATF4 EIF2A PMC4442386__F8 Model for the overall disruption of IFN responses by SFTSV through NSs hijacking of signaling proteins in IBs TBK1 STAT1 STAT2 IRF9 IRF3 PMC6262249__F2 Role of macrophages in hepatitis C virus infection-associated inflammation TLR1 NLRP3 TLR8 TLR7 IL6 IL1B MYD88 PMC9466593__F1 Effect of antifungal resistance development on the virulence of Candida species ALB CDR2 PMC6831489__F5 Schematic summary of the responses on energy metabolic pathway reprogramming by genotoxic or non-genotoxic hepatocarcinogens in rat liver cells GLS MPC2 ATP5IF1 PMC12024137__F3 Research Progress on Hypoglycemic Effects and Molecular Mechanisms of Flavonoids: A Review PDX1 FOXO1 TNF IRS1 PMC8846368__F2 Targeting Nutrient Dependency in Cancer Treatment PIK3CA MTAP KEAP1 BAP1 SLC7A11 MYC PMC8846368__F1 Targeting Nutrient Dependency in Cancer Treatment ASS1 ASL GLS SLC7A11 ASNS PMC4378640__F4 Schematic presentation of chloroplast proteins affected in executer mutants and WT plants after light treatment compared to WT plants under normal or growth light conditions, as shown in Table 3 RPE TPR PC PMC4982039__F1 Hypoxia‐induced changes in mitochondrial metabolism HEL60 ACO2 MAL PC HEL-S-26 ADSL CIT PMC8894956__F4 First-line immunotherapy or angiogenesis inhibitor plus chemotherapy for HER2-altered NSCLC: a retrospective real-world POLISH study IFNG TBK1 CGAS IRF3 PMC9508558__F8 Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma FAS CES2 MYC PMC6375688__F1 Proteostasis regulation ATF4 EIF2A PMC6487307__F1 Polyamine metabolic pathway AMD1 SLC3A2 HEL-S-18 SMS SRM SMOX PAOX ADI1 PMC8186080__F7 Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression ATG16L1 ATG12 MTOR PMC5882219__F3 Reciprocal regulation of YAP by TRIO-RAC1 signaling and the Hippo pathway TRIO RAC1 RUNX3 PMC3056141__F1 DNA-mediated activation of innate immune signaling TBK1 IL13 AIM2 IRF3 TRAF3 FADD PMC4885841__F6 Schematic diagram demonstrating the immunomodulatory and therapeutic effects that grafted stem cells exerted on the recipient upon transplantation EGF NGF GDNF TLR3 TLR4 MSC BDNF PMC9209741__F3 Medulloblastoma and the DNA Damage Response ATR BAD ATM PTEN MDM2 PMC7847335__F1 Toll-like receptor-signaling pathway during pulmonary infections CSA2 TIRAP IL16 TLR4 PMC3173728__F1 In this figure we show the two main pathways to apoptosis, and their interaction through the molecule BID, since death receptors activate the intrinsic pathway by activating BID BAX FAS BCL2 APAF1 FADD PMC2862880__F3 Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer SRD5A2 HSD17B6 CYP17A1 CYP11A1 HSD3B1 AKR1C2 AKR1C1 PMC7199629__F2 Regulatory mechanisms and biological functions of MTHFD2 in cancer MTHFD2 ATF4 SOX7 PMC4651701__F1 Targeting IL4/IL4R for the treatment of epithelial cancer metastasis IL13RA1 JAK3 IL4 MTOR JAK1 TYK2 IRS1 PMC4825019__F5 Ingenuity pathway analysis identifies two highly enriched networks for the Tau-interacting proteins HEL-S-77 HEL-S-11 CS PMC4347943__F1 wRAPping up early monocyte and neutrophil recruitment in atherogenesis via AnnexinA1/FPR2 signaling FPR2 CCL5 CCL2 PMC8782720__F8 Proposed model of the role of DAB2IP’s phosphorylation in SAC maintenance and cancer development suppression CDC2 CDC20 APC DAB2IP PMC3588168__F1 Simplified schematic of signaling pathways driving resistance to BRAF inhibitors ARAF BRAF PTEN IGF1R PMC8472725__F1 Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association LAMP2 EEA1 PMC6277637__F11 Inflammatory pathways in osteoarthritis TH PTH IL1B PMC7497193__F1 Two major signalling pathways implicated in melanoma PLCB4 NF1 KPG_011 EGFR KIT GRB2 MTOR PMC6560203__F3 Hydrogen sulfide interaction and effects upon the activity of its biological targets ATR RPS3 KEAP1 HEL-S-11 PMC9032563__F1 Mapping Molecular Networks within Clitoria ternatea Linn. against LPS-Induced Neuroinflammation in Microglial Cells, with Molecular Docking and In Vivo Toxicity Assessment in Zebrafish VASP ARHA RHO PMC7195008__F1 Pathophysiologic Model of Immunothrombisis in COVID-19 TF ACE2 PMC4324508__F1 Microbiota modulation of myeloid cells in cancer therapy RB1 IFNG BAX HMGB1 ATR FAS TLR4 TLR9 TNF PMC9372905__F1 Rare Variants in the Norrin-FZD4 Signaling Pathway and Familial Exudative Vitreoretinopathy (FEVR) With Extraocular Phenotypes FZD4 APC TSPAN12 GSK3B LRP5 CTNNB1 NDP PMC5052620__F10 Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGFB pathway in precancerous Oral Submucous Fibrosis JUN THBS1 SMAD2 BMP7 ATF2 PMC2719559__F2 Paracrine and autocrine mechanisms of Akt-mediated tumor-stromal interactions IGF1 CCR5 CCL5 CXCR4 PMC4156720__F1 Cotargeting the PI3K/AKT and AR pathways in CRPC FKBP5 PTEN MTOR PMC6272897__F5 Putative pathway for the inhibition of inflammatory signaling events by AQCA in in vitro inflammatory responses SYK TLR4 IRAK1 ATF2 SRC MYD88 PMC8670943__F1 Chinese Herbal Medicine Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress ATF4 CHAD EIF2A PMC6233323__F1 Integration of Drosophila and Human Genetics to understand Notch signaling related diseases CDK8 MIB1 NUMB PMC7753942__F2 Summary of immunopathogenesis in early and late SARS-CoV-2 infections MAVS STAT2 IRF9 IRF3 JAK1 ACE2 TYK2 PMC9428632__F4 Roles of glycolysis in osteosarcoma EGFR ROR2 MTOR PMC7398066__F2 ABC transporter-related signaling pathways ABCG8 ABCG5 IGF1 FOXO1 TLR4 CRH PC ABCA1 GPS2 CRHR1 PMC5034715__F4 Metabolomics analysis of hormone-responsive and triple-negative breast cancer cell responses to paclitaxel identify key metabolic differences MAP4 MAP2 CYP1B1 ABCG2 CYP3A4 ABCC2 PMC8377944__F1 Secondary hypertension: An update on the diagnosis and localisation of a pheochromocytoma or paraganglioma TH PNMT PMC9145792__F9 Artonin F Induces the Ubiquitin-Proteasomal Degradation of c-Met and Decreases Akt-mTOR Signaling BAX HGF MTOR PMC7601870__F2 Crosstalk between CK2 and signaling pathways (A) regulating fatty acid synthesis or (B) controlled by phospholipases ACLY RHEB TSC2 SP1 PLD2 SCD FASN USF1 ARF6 LDLR PMC11792405__F3 TSC1-TSC2 complex in ovarian GSCs, Nephron progenitor cells and ISCs TSC1 APC ZNRF3 LRP6 MYC CTNNB1 PMC9707069__F2 From mesenchymal niches to engineered in vitro model systems: Exploring and exploiting biomechanical regulation of vertebrate hedgehog signalling KIF7 BOC SUFU SMO ARHA GAS1 RUNX2 RAC1 PMC3684428__F2 IRE1Alpha- and PERK-mediated cell death pathways ATF3 BCL2 ATF4 EIF2A TRAF2 PMC3684428__F1 The adaptive unfolded protein response (UPR) TF ELF2 ATF4 EIF2A XBP1 PMC8494682__F1 Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway PPCS ERG NUS1 PPCDC PMC7854640__F7 Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution LAMP3 CXCL13 CX3CR1 EGFR CX3CL1 CXCR5 CCR4 NOTCH2 PMC9441498__F6 Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma PTEN CCND1 PMC9596393__F4 Understanding the molecular mechanisms of macrophage polarization and metabolic reprogramming in endometriosis: A narrative review HEL-S-133P PMC2794560__F1 Metabolic pathways of tamoxifen CYP2C19 CYP2C9 PMC4367126__F1 Induced regulatory T cells in inhibitory microenvironments created by cancer COX2 PDC NRP1 FOXP3 LAG3 PMC4926327__F7 Mechanism of stimulated VSMC proliferation through the Wnt4/Dvl-1/Beta-catenin signaling pathway APC WNT4 FZD1 CTNNB1 PMC5332939__F1 Diagrammatic representation of the EGF signaling pathway STAR EGFR GRB2 PMC3384069__F1 Wnt/Beta-catenin signaling pathway APC GSK3B CTNNB1 PMC7381619__F1 Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression KEAP1 GC FES H1-0 PMC11852973__F3 Therapeutic strategies targeting the AIM2 inflammasome in cancer PDC AIM2 CXCL10 FGF2 PMC4285816__F6 A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS) STAT3 JUN ATF1 TRAF2 PMC11852973__F1 Tumor-derived double-stranded DNA (dsDNA), which can be derived by genomic instability, activates AIM2 inflammasome and cGAS-STING signaling pathway CGAS AIM2 IRF3 PMC3976626__F8 By simultaneously inhibiting CBS activity and inhibiting GOT1, a key enzyme of the malate/aspartate shuttle, AOAA acts as an inducer of ‘synthetic lethality’ in cancer cells GOT2 PMC7551862__F7 FO promotes bone formation and growth by activating the IGF-1/IGF-1R signaling pathway IGF1 GSK3B IGF1R RUNX2 PMC4255622__F1 Signaling pathways: HN exerts its function through both extracellular receptors and intracellular binding partners STAT3 BAX CNTF TRIM11 VSTM2L PMC3489928__F4 Proposed Reaction Pathway SI CS PMC9647168__F1 Modification of phosphoinositides by the Shigella effector IpgD during host cell infection TIAM1 EGFR PMC7042182__F8 Sketch map of the signaling axis with the most significant co-expression pattern including YY1 (Yin and Yang 1 Transcription Factor), Hepatitis A Virus Cellular Receptor 2 (HAVCR2) and mTOR signaling pathway HAVCR2 CD14 YY1 LGALS9 MTOR PMC11676689__F4 FoxO signaling KEGG pathway; (B) ABC transporters KEGG pathway TF STAT3 TH KLF2 SMAD4 BNIP3 PTEN ARC INS SKP2 ATM MDM2 POT1 CMC4 ABCD2 GLA ME1 ABCB10 ATG12 ABCB4 PEMT CDK2 NLK MB SIRT1 PMC10488162__F4 The Nrf2 signaling pathway in environmental pollutant-related ovarian aging KEAP1 NQO1 MAF PMC3071166__F3 Hypothetical scheme of the proposed mechanisms contributing to the induction of tolerance by SIT TFG PMC7092629__F2 Predicted protein-protein interactions in aSyn pathology: hypothesis and bioinformatic analysis STXBP1 HEL-S-123m PPIB PINK1 RPS14 ATP6V1A SLC25A3 SNCAIP STUB1 FBXW7 GOSR2 HSPD1 AP2A1 SYT2 ND2 HSPB8 STX1A MST065 HTT UBB PRPF19 RPS23 DNAJB1 SIAH1 RNF10 ATP5PB SLC25A13 SNCA ATP6V0D1 POLR2H AP2M1 UQCRC1 TFAM SNRNP200 SLC25A12 SLC25A11 NEDD4 UQCRFS1 TAF7 HMGB2 HEL-S-103 PPIL3 UQCR10 CBX4 PARK2 SAP30BP HEL-S-100n UQCRQ SLC25A22 EIF2S1 P3H1 DDX1 SIAH2 UQCRB RPS3 SYP UQCRC2 POLR2L EEF1A1 PDIA2 HEL-S-72p HMGB1 UBC HNRPA3 LRRK2 HEL-S-67p HEL-S-89n EIF5A FKBP3 MEF2D LAMP2 ENSA FKBP4 STX5A WDFY3 RAB5A SNAP25 AP1B1 SYN1 PMC10488162__F3 The Nrf2 signaling pathway in age-related ovarian aging TF GPX4 NQO1 MAF CCNB1 SIRT1 HEL-S-44 PMC2834432__F1 Phosphatidylinositol 3-kinase (PI3K) signaling cascade RHEB MLST8 TSC2 BAD RICTOR TSC1 PTEN MDM2 MTOR PMC4009396__F2 microRNAs in cancer DGCR8 XPO5 AGO2 DROSHA PMC2721377__F1 Molecular toll-like receptors (TLRs) of the human gastrointestinal (GI) tract which act as sensors and are the first responders in the major pathway by which the immune system detects infection or damaged tissue JUN LTA TLR4 CD14 TLR5 PMC7432706__F2 Leptin receptor signaling pathway, and alterations in signaling that characterize various ganglioside-deficient KO mouse models STAT3 POMC SOCS3 AgRP SH2B1 PMC7432706__F1 Biosynthetic pathway of ganglio-series gangliosides UGCG B4GALNT1 ST3GAL5 B4GALT5 B3GALT4 PMC6710477__F1 Schematic overview of cytoplasmic 60S subunit assembly EFL1 EI24 SBDS NMD3 LSG1 EIF6 DRG1 DNAJC21 PMC10854734__F5 SADS-CoV infection induces apoptosis and complete autophagy CASP9 CASP8 ULK1 ALG13 ATG14 MTOR FADD PMC8964401__F7 Dynamics and Functional Interplay of Nonhistone Lysine Crotonylome and Ubiquitylome in Vascular Smooth Muscle Cell Phenotypic Remodeling HEL107 RPE SDHA DLAT HEL-S-304 RPIA HEL-S-133P HEL-S-162eP PDC DLD CS PMC8103580__F1 Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy HTRA2 BAX FAS CAD HEL-S-130P BCL2 APAF1 FADD PMC8103580__F4 Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy ATG10 ATG3 ATG12 ULK1 AMBRA1 ATG14 BCL2 ATG5 ULK2 PMC8103580__F3 Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy RIPK3 HMGB1 TRADD MLKL TLR4 TAB3 IL33 TRAF5 TNF CYLD TRAF2 FADD PMC7933775__F1 Hippo signaling pathway LATS1 MOB1A LATS2 WWC1 NF2 AREG PMC2956014__F2 Neutrophil apoptosis BAX TRADD MCL1 TNF APAF1 TRAF2 FADD PMC3565545__F9 BRCA pathway showing the role of BRCA1 in DNA damage response and crosstalk with other biological pathways, notably the P53 pathway.Notes: Double circles indicate complex interactions involving multiple genes MSH6 ATR RAD50 ATRIP MSH2 PLK1 MDC1 BLM BARD1 IFNG STAT1 BACH1 MRE11A ATM ATF1 PMC8860543__F8 TNFA Antagonizes the Effect of Leptin on Insulin Secretion through FOXO1-Dependent Transcriptional Suppression of LepRb in INS-1 Cells TF STAT3 FOXO1 PMC5081415__F4 KEGG analysis of STRING network of C PLB1 NRG1 CYR61 MSI1 MSL1 UXS1 CIRSR ZNF2 CCR4 URAD PCK1 PMC4539002__F1 Proteostasis network (PN) NBR1 CANX BAG3 ATG5 HIKESHI PMC7176878__F2 NFKBIA is involved in the NF‐KB signalling pathway SYK EGF LTA LTBR TRADD TIRAP LAT IRAK1 TRAF3 TRAF6 IRAK4 MYD88 NGF PLCG1 BTK PLCG2 COX2 BCR ATM CD14 BLNK PARP1 LTB TRIM25 TRAF5 TRAF1 LYN VCAM1 LBP TRAF2 LCK PMC4629839__F1 MTOR pathway RHEB EEF2K TSC2 EIF4B RICTOR TSC1 PIR MTOR IRS1 EIF4E PMC3439567__F2 P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation EGFR APP RHO GRB2 SRC FLNA PMC4523019__F2 Interferon signaling upstream regulator pathway, with subcellular compartmentalization indicated SOCS1 CXCL9 TRIM14 CHAC1 HEL-S-62p PLSCR1 TNLG7A CXCL1 IFIT3 IFIT2 IGFBP4 C1QB TAP1 APOL3 RTP4 PARP12 USP18 IFITM3 APOL1 MMP2 BMF TAP2 ISG15 OAS1 PSME2 HRK OAS2 CEACAM1 SPRY4 IRF9 SP110 LGALS9 GBP1 RSAD2 OAS3 LAMP3 TLR3 ApoL6 CISH PMC8513137__F4 Glucagon’s Metabolic Action in Health and Disease SIK2 HEL-S-5 CRTC2 GCGR PCK1 PMC3578033__F2 Inflammation and Diabetes-Accelerated Atherosclerosis: Myeloid Cell Mediators ACSL1 LOX AKAP11 AKAP8 PC AKAP10 PMC3076854__F2 Global transcriptome analysis reveals CB1R-dependent, PHX-induced up-regulation of key cell-cycle proteins ATMIN EGF COMP PMC8647113__F11 Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases CDC42 PREX1 BAD RHOD ITK GRB2 SHE DOCK2 PMC8647113__F10 Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases MAX GAL FAS TRADD APMAP CD14 TNF TRAF6 F2 APP GRB2 MIP TRAF2 PMC2958130__F5 Intertwining Threshold Settings, Biological Data and Database Knowledge to Optimize the Selection of Differentially Expressed Genes from Microarray LY96 TLR4 CD14 VCAM1 MMP9 TRAF6 LBP PMC8637208__F5 Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function LATS1 LATS2 FYN ARHA CTNNB1 PMC10674800__F6 Transcriptomics and Physiological Analyses Reveal Changes in Paclitaxel Production and Physiological Properties in Taxus cuspidata Suspension Cells in Response to Elicitors IPP MVD MVK PMC11242595__F2 TGFB Modulated Pathways in Colorectal Cancer: New Potential Therapeutic Opportunities STAT3 SRC TRAF6 TUG1 PMC8304794__F5 Transcriptomic Profiling of Femoral Veins in Deep Vein Thrombosis in a Porcine Model LTA APP HEL-S-11 TNF STRAP PMC3517905__F1 Summary of the signaling pathways of PKMζ-mediated late-LTP PRKCZ MTOR BDNF HEL-S-30 PIN1 PMC3923158__F2 Components that determine the establishment and tolerance-inducing capacity of tolerogenic effector DCs VIP STAT3 CD80 FAS TNF PMC1856765__F7 Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications BAX CS ATF2 IL6 TNF FADD PMC8504858__F2 Inductive Materials for Regenerative Engineering SMAD1 SOST DKFZp781O1323 SUFU APC GSK3B SMAD6 SMAD4 SMO ADAM10 RUNX2 CTNNB1 PMC8874480__F2 JAK2 in Myeloproliferative Neoplasms: Still a Protagonist STAT3 MPL PMC3814363__F4 Structure-based phylogenetic tree of ATPase enzymes MMAA RAD50 DMC1 CFTR GET3 RHO ELP4 PMC6278419__F5 PPI network and module analysis ALB AHSG APOH AMBP APC HEL111 PLG APOB FGA PMC3583555__F1 Simple model for regulation of breast cancer initiating cells (BT-IC) self-renewal in breast cancer BMI1 SUFU SMO PMC9687165__F3 Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways KLF4 MAFB SIRT1 CSF1R PMC1856765__F3 Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications BAX FAS FADD PMC3583555__F2 Regulation of apoptosis by several pathways BAX RTKN ITGB3 PMC3433902__F5 Immune response to phagosome in antigen presentation network pathway map associated with the proteins identified as differentially regulated during zebrafish caudal fin regeneration CRP VASP ROCK2 LAT HEL-S-269 CRKL ARF6 TRAM1 VTN BLNK ARHA CABP1 CD74 RALA c-fgr ELMO1 PAK1 GRB2 LBP CD6 PMC7483256__F2 Small-molecule drug repurposing to target DNA damage repair and response pathways ERCC1 XPA MSH6 RAD51 MSH2 PMS2 PCNA FANCM FAN1 XPC DDB2 DDB1 LIG1 FAAP24 POLE PMC8471347__F3 NFKB Nucleolar Stress Response Pathway POLL RELA POLI CCND1 CDK4 PMC8471347__F1 NFKB Nucleolar Stress Response Pathway BAX RELA COMMD1 PMC7580254__F9 Schematic diagram representing the role of Bruton's tyrosine kinase (BTK) in the pathophysiology of sepsis BTK CXCL1 IL1B PMC7483256__F3 Small-molecule drug repurposing to target DNA damage repair and response pathways RAD51 MRE11A BRCA1 WRN BRCA2 ATM POLE BLM RMI1 XRCC3 PMC12210561__F2 Gln modulates multiple signalling pathways to regulate cancer cell proliferation LATS1 EPHA2 GLS EGFR ASNS PMC7425451__F5 Downregulation of miR-135a on RAB1B and the RAS signaling pathway in NSCLC cell progression RAF1 ARHA RAB1B RAC1 PMC7297132__F1 Characteristics of astrocyte senescence HMGB1 NGF GFAP IGF1 H2AX IL6 PMC7346762__F2 TrkB signaling-mediated cell survival and the Nrf2-ARE antioxidant system MAF GRB2 BDNF PMC8234271__F2 MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma FLT3 SOS1 EGFR BRAF IGF1R FGFR2 ALK NF1 ERRFI1 FGFR4 FGFR1 RIT1 MAPK1 ROS1 ERBB4 NTRK2 PTPN11 KIT KRAS RAC1 ARAF ERBB3 HRAS CBL PDGFRA NTRK1 ERBB2 FGFR3 MAP2K1 RET PMC8234271__F1 MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma EGFR KIT GRB2 PMC10340761__F4 Gene interaction pathways and their regulation in cancer EGLN3 CA9 BHLHE41 COXFA4L2 PMC8069355__F3 Speculative model of theta-mediated end joining (TMEJ)/Polθ activity as back-up repair of DSB in homologous recombination (HR) deficient cells RAD51 BRCA1 POLE PMC6629462__F1 Transport processes and regulatory mechanisms in A- and B- and non-A, non-B IC RHBG PC RHCG PMC6027519__F2 Regulation of innate and adaptive immunity by hypoxia and HIF signaling pathway IL6 CXCL8 IMPACT PMC11058607__F2 Pathways in HNSCC cells involving growth factor receptors like TGFB causing cell migration and invasion leading to metastasis TGFBR2 MAP3K7 MTOR TGFBR1 PMC7048923__F6 PPI network of “drug-compound-target-pathway” of cinobufotalin injection for lung cancer FLT3 AURKA PPARG PIK3CA PGR HEL111 TERT TYMS MTOR SETD2 MPO FGFR2 MME CHEK2 PRKCA MMP2 ELANE KDR MDM2 SRC FHIT TYMP NR1i1 AXL KIT EZH2 DPYD PTGS2 PTK2B TNF VHL HPGD EDNRA CASP3 BCL2 EP300 CA9 RET ADA PMC8847160__F1 Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy TF GPX4 PMC7763058__F1 TGFB signaling in fibroblasts LIMK2 SMAD2 SMAD4 RHO PMC3857155__F1 Basic depiction of the classical view of the PI3K signaling network (black arrows) as well as the novel signaling pathway revealed in the study by Tan et al PTEN MTOR MYC PLK1 PMC6343466__F1 The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis JAK3 JAK1 TYK2 PMC4111858__F5 Two-step model for OR-instructed axonal projection of OSNs KIRREL2 KIRREL3 PLXNA1 NRP1 PMC7969115__F3 Biomarkers play role in pathology of OA by multiple signaling pathways including NFKB pathway, MAPK pathway, Wnt-signaling pathway, and TLR pathway TLR4 APC LRP5 LRP6 ATF2 IL6 VCAM1 MMP9 PMC5854644__F9 MicroRNAs (miRNAs) related to the epigenetic control of genes involved in demyelination, epithelial–mesenchymal transition (EMT), inflammation, pain, and loss of sensation were differentially expressed in leprosy patient (LP) CDC42 TGFB1 RAF1 SMAD2 SOX10 MEF2C TGFBR1 MAPK14 ERBIN SOX9 ROCK1 ZEB2 HOXC8 HOXB5 SNAI2 JUN TRPV1 ATP1A1 ARHA KRAS RAC1 CD44 HOXB7 SIGMAR1 ERBB2 AQP1 PMC8394875__F3 Ovarian Cancer and Cancer Stem Cells—Cellular and Molecular Characteristics, Signaling Pathways, and Usefulness as a Diagnostic Tool in Medicine and Oncology RNF43 APC GSK3B AXIN1 LRP5 ZNRF3 LRP6 GPR49 AXIN2 CTNNB1 LGR6 PMC10944252__F2 Enrichment analysis of KEGG signaling pathway, hub gene screening and PPI network analysis based on Genemania database BMS1 RPL27A PA2G4 NHP2 EMG1 WDR36 MRPS12 RPS3A MRPL24 RPS24 MRPS15 RPL27 EEF2 PMC9142523__F7 Adipokine human Resistin promotes obesity-associated inflammatory intervertebral disc degeneration via pro-inflammatory cytokine cascade activation NLRP3 TLR4 IL1B PMC3349963__F1 Canonical and non-canonical IL-13 signaling in cells STAT3 IL13RA1 TYK2 PMC3001886__F5 Coxiella burnetii, the Agent of Q Fever, Replicates within Trophoblasts and Induces a Unique Transcriptional Response IFNG STAT3 RHD TGFB1 ADM IL13 IL4 APP IL6ST IL13RA2 PMC11274159__F2 EBV-affected signaling pathways associated with ferroptosis POR FANCD2 SLC3A2 ATF3 SLC40A1 CDKN1A ELAVL1 GPX4 DPP4 SLC7A11 PMC7093293__F4 Role of Rho/Rho-kinase pathway in the pathogenesis of cardiovascular diseases VAMP2 BMP2 RHO MIF PMC8394875__F4 Ovarian Cancer and Cancer Stem Cells—Cellular and Molecular Characteristics, Signaling Pathways, and Usefulness as a Diagnostic Tool in Medicine and Oncology BMI1 CD44 MYC CCND1 PMC1526619__F1 Wnt/Beta-catenin signaling pathway APC GSK3B WNT1 CTNNB1 PMC1526619__F2 The canonical transforming growth factor (TGF)B/Smad signaling pathway SMAD2 SMAD4 PMC33831__F1 The branch of the flavonoid pathway for the synthesis of flavones in maize C2 HP PMC4349862__F6 Overexpression of the Transcription Factor Sp1 Activates the OAS-RNAse L-RIG-I Pathway MAVS RNASEL IRF3 PMC8127782__F4 Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response BAX BCL2 APAF1 PMC6359724__F1 Oxygen- and hydroxylase-dependent mechanisms regulating hypoxia-inducible factor 1 (HIF-1) activity FH USP20 HEL-117 PMC9360036__F7 Proposed model of MAP4K4 and STRN3 regulation of cell migration and proliferation in MB HEL-S-31 ANKRD1 VASP STRN3 PMC7824611__F4 Diphthamide synthesis and ADP-ribosylation DPH1 DPH2 DPH3 DPH5 EEF2 PMC6359724__F2 HIF-1-dependent reprogramming of the glucose metabolic pathway, and resultant radioresistance BNIP3 MYC MXI1 PMC7838823__F4 Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses TF MAPK1 STAT3 GNAI1 JUN YES1 AKT3 HIF1A YY1 MYC KMT2A PNP PIG59 E2F3 NFKBIA BCAT1 SRPK2 ADORA2B ADA PMC7824611__F5 Proposed model of Cholix-induced cell death pathways ROCK1 EEF2 FURIN PMC6813369__F2 Proposed role of the immunogenic cell death in pemphigus foliaceus HEL-S-99n ELL SIRPA CD47 PMC6995557__F5 Schematic diagram of the proposed mechanisms by which betulinic acid ameliorates T-2-toxin-induced oxidative stress and diminishes T-2-toxin-induced apoptosis via the JAK2/STAT3 and BAX/BCL-2/caspase-3 pathways BAX PMC6255967__F4 Canonical IRF5 signaling pathway and its negative regulation IL10 CRTC3 SIK2 TLR8 TLR7 LYN IRF4 TRAF6 TNF IRAK4 TRIM21 MYD88 PMC7345582__F3 Oncogene miRs that activate the STAT3 signaling pathway and promote the proliferation and invasion of GC cells STAT3 SOCS4 IFNAR1 SOCS2 MYC PMC7345582__F2 Onco-suppressor microRNAs in the inhibition of STAT3 and the malignant behavior of gastric cancer cells STAT3 HAS1 TWIST1 PMC7345582__F5 STAT3 signaling pathway as an oncogene factor in GC cells CD44 STAT3 EZH2 CD163 CCND1 PMC5003917__F2 Aberrations in the cyclic AMP-dependent signaling pathway in adrenocortical tumors PDE11A FH ARMC5 MEN1 MC2R PRKAR1A CTNNB1 PMC11490128__F7 Schematic model delineating the mechanisms of SEC14L3 in ccRCC RPS3 NFKB1 PMC7345582__F4 Long non-coding RNAs and their downstream targets in the regulation of the STAT3 signaling pathway in GC cells STAT3 PMC7563732__F4 Enzymes from the purine salvage cycles identified in the L APRT ASL GMPR GDA PMC7960772__F1 Immune environment surrounding a transplanted organ CD80 TIGIT APC ELL ARG1 LAG3 PMC3134325__F1 Action of ErbB receptor EGF TGFA GRB2 PMC5575491__F5 Model of melatonin regulation of bone mass TPH1 AANAT ASMT PMC8924487__F1 Extracellular Vesicles in Systemic Lupus Erythematosus LAMP2 SP1 CD82 MSC TRAF6 TNF CP PMC6896143__F4 A diagrammatic representation of the pathways that can indirectly lead to inhibition of apoptosis in a cancer cell STAT3 HGF JAK1 CTNNB1 PMC3418714__F3 Kinase inhibitors in CLL SYK BTK BCR BLNK LYN PMC3418714__F2 Integrin signaling in CLL SYK BTK BCR BLNK LYN PMC3564018__F7 Transcription factors predicted to be inhibited by battlefield-like stressors and their targets among stress-modulated genes CD79A HLA-DOB HLA-DRB1 CXCL1 RELB SBF1 HLA-DPA1 ACTA2 HLA-DRA COL1A1 AFP CD74 MHC2TA CCR7 IL18 A2M CREB1 CDH2 HMGB1 IRF1 B2M IRF7 IL1A CD44 PDE3B CDKN1A PLK3 NFKB1 RELA HSPA4 HLA-B PF4 PMC6527602__F2 ERM structure and function in immune cells CXCL12 SYK ADAM17 F2 F3 COIL SRC LCK PMC12097394__F2 TLR/NFKB mediated inflammatory signaling and involvement of E3 and DUBs OTUD4 SPOP MYSM1 TIRAP USP4 IL6 TRAF6 IL1B MYD88 PMC3418714__F1 B-cell receptor signaling in CLL SYK BTK FYN PLCG2 BLNK LYN GRB2 PMC12097394__F4 Involvement of E3 ligases and DUBs in calcium handling USP25 RYR2 JOSD2 CBL UBE2C PMC12097394__F3 Extrinsic and intrinsic apoptosis signaling pathway and involvement of E3 and DUBs BAX USP27X TRADD USP24 APAF1 FADD PMC7097917__F1 L-serine synthesis pathway PHGDH SHMT1 PSAT1 HEL-S-51e PSPH PMC10746942__F2 The function of SAMMSON in different cancers ME3 SP1 CTNNBIP1 EZH2 PMC10746942__F1 SAMMSON via different mechanisms exerts its oncogenic roles in melanoma CARF EZH2 FOXA2 PMC5955117__F6 p53 and metabolism: from mechanism to therapeutics TIGAR IL8RB MTOR PMC12005349__F1 Signalling scheme of the TGFB‐SMAD signalling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD4 TGFBR1 PMC8981989__F2 Glucose, Fatty Acid and Amino Acid Metabolism by Ubiquitination and SUMOylation for Cancer Progression HEL-S-133P APC HIF1A TRAF6 SAE1 STUB1 VHL TRIM21 UBA2 SUMO2 SENP1 HEL-S-162eP USP22 TRIM11 RNF20 ENO1 HEL-S-87p OTUB2 PMC5955117__F1 P53 regulates critical points in cell signaling and metabolism TSC2 PHGDH TIGAR SCO2 HP MDM2 GLS2 PMC6643298__F9 The conclusion of the results in this study CHPT1 PC SMPD1 PMC4355577__F2 Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? CXCL12 TNC HGF MMP10 MSC IL4 MMP2 MMP3 IL6 MMP9 VEGFA PMC10918892__F5 Schematic diagram illustrating the role of miR-223-3p on NLRP3 inflammasome signaling pathway in LPS-induced HTR8/SVneo cells GSDMD NLRP3 TLR4 MYD88 PMC9327246__F8 d-Borneol enhances cisplatin sensitivity via p21/p27-mediated S-phase arrest and cell apoptosis in non-small cell lung cancer cells and a murine xenograft model BAX PGP CDK6 CDK2 PMC6697022__F2 Tyrosine kinases in the development of atopic dermatitis SYK TSLP BCR JAK3 JAK1 PMC5745276__F2B Non-Canonical Wnt Pathway and the Notch and Sonic Hedgehog Pathway-The two major non-canonical pathways are Wnt/calcium and Planar Cell Polarity (PCP) pathways SUFU SMO ARHA HES1 CTNNB1 PMC5745276__F2A Canonical Wnt Pathway and Inhibitors of the Wnt/beta-Catenin Signaling Pathway GK3 APC TNIK CTNNB1 PMC8110204__F2 Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus STAT3 HMGB1 COX2 IL18 IL2 HIF1A FOXP3 MTOR SIRT1 BCLAF1 IL9 MYD88 PMC8329528__F1 Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism RHEB TSC2 TSC1 ULK1 PTEN IRS1 SLC38A9 PMC4621929__F3 STRING network analysis reveals a database of known and predicted protein interactions ARHGAP22 EGF PLCB4 BANP USP45 EGFR SMAD2 FICD USP29 ABCB8 TACC3 CALCOCO1 KHDRBS2 ROCK1 MEGF9 MAF CEBPZ A2M MEGF8 SRC RND2 DNER ABCC2 ABCB1 DYRK2 MEGF11 LCP2 GNB2 MEGF6 EID2 CELSR2 NUP62 DOCK1 GTF3C1 SLA2 FARP2 EP300 MCM6 ELK3 JAK1 UHRF1 LEF1 MYO9B PMC5854419__F1 Mitogen-activated protein kinase signaling in plant pathogenic fungi SF1 CAP1 PMC4023360__F1 Role of Heat shock protein-27 (HSP27) and clusterin (CLU) in cancer cell survival BAX BAD FAS IGF1 CLU IGF1R TNF PMC5545725__F4 Proposed model of dopamine dysregulation in the nigrostriatal pathway in schizophrenia TH DRD2 MAOA PMC3994501__F9 Signaling pathways for LTM formation upon associative olfactory conditioning of honeybees CA11 CS PMC3633862__F6 Interferon-Beta Induces Distinct Gene Expression Response Patterns in Human Monocytes versus T cells CDC42 HMGB1 SP1 STAT2 PSMB8 IRF9 IFITM1 IFIT3 IFI35 RHO RAC1 IFNG STAT1 TLR4 MX1 VCAM1 JAK1 OAS1 TYK2 PMC7532351__F4 Signalling Pathway Underlying PAK1-Blockers and Viral Infections PAK1 PTEN CCL2 ACE2 PMC11599025__F1 Innate immune responses against ASFV infection CGAS MAVS STAT2 IRF9 IRF3 TRAF3 STAT1 NLRP3 TLR3 TLR4 TLR8 TLR7 JAK1 TYK2 PMC5351205__F1 Sub-pathway enrichment analysis of differentially expressed genes (DEGs) ACSS2 SUCLG1 PCCB ACSS3 ACADM MCEE PMC5847475__F2 Mechanism of PD-1 and PDL-1 pathway in tumor environment and the complex crosstalk between cancer, tumor, T-cell, APC and macrophage and tumor stroma HGF APC RGMB PMC6838750__F2 Main processes involved in exercise-induced and neurotrophin-mediated increased viability of dopaminergic neurons TH BAX BCL2 PMC10778705__F3 cGAS-STING antitumoral and protumoral mechanisms STAT3 TBK1 CGAS PARP12 IRF3 PMC11625754__F4 Effect of AB on the NMJ formation process MUSK LRP4 APP PMC10374777__F2 Molecular mechanism of ferulic acid and its derivatives in tumor progression BAX CDK6 PCNA CDK2 MTOR CCND1 CDK4 PMC11667055__F6 Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation TLR4 ACOD1 NFATC1 PMC9181281__F10 Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NFKB Signaling COX2 TLR4 IL6 PMC7327948__F3 Diagram describing the possibility for Roflumilast to increase DCX and MAP2 expression NGF DCX BDNF PMC6351175__F7 Hypothesized regulatory relationships between TGFB, Tgif1, miR‐18a, and NeuroD during photoreceptor differentiation SMAD2 TGIF1 PMC2869029__F1 Regulation of macrophage function in tumors: the multifaceted role of NFKB STAT3 IRF1 ARG1 IRF3 IRF7 SOCS3 IL6 CXCL10 MYD88 IFNAR2 IFNAR1 ARG2 IL1B PMC8143176__F1 Store-Operated Calcium Entry: Shaping the Transcriptional and Epigenetic Landscape in Pancreatic Cancer HSF1 CREB1 PMC8323226__F5 Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications CD80 CD163 PMC7131993__F1 Increased matrix stiffness can affect cells in different signaling pathways in colorectal cancer (CRC) APC GSK3B LRP5 LRP6 RHO SRC CTNNB1 PMC11484773__F2 Schematic diagram illustrating the interaction between neuroinflammation and microglial activation, as well as a separate schematic diagram depicting the TREM2 signaling pathway TREM2 SYK ADAM17 ADAM10 TNF PMC5522997__F9 Representative gene networks that were significantly regulated (P < 0.05 with the Fisher's exact test) in response to cocaine in WT compared to SERT Met172 mice RASD1 SCN8A SMG1 CNTNAP1 NEFL TNR RPL37 CDC42EP3 ABCA1 KCNA1 RPL39 RIC8B TTLL7 TU3A SLC6A11 KCNAB1 PFDN5 RYR2 VWF LRP8 TMEM158 GNG13 LRRK2 GNB5 KCNA5 SCN1A PTPRT IRS4 RGS11 DFFB NEF3 PARM1 PTPRG SET NEK1 SCUBE1 LRP1B PTPRB B3GNT2 PMC10152446__F7 Structure Elucidation and Biosynthesis of Nannosterols A and B, Myxobacterial Sterols from Nannocystis sp. MNa10993 IPP EBP PMVK DHCR24 DHCR7 MVK PMC7851492__F1 Conflicting metabolic alterations in CSCs FBP1 MYC PMC5549772__F2 Salmonella enterica serovar-specific transcriptional reprogramming of infected cells SOCS1 STAT3 VLDLR EDN2 SDC4 SOCS2 BNIP3 HIF1A IRAK2 SOCS3 CCL5 CCL2 EFNA1 CXCL3 EDIL3 HEL-S-42 BCR OSMR ITGA2 OASL CCL7 SAA1 PFKFB4 ADM JUNB IRF9 PLAUR IFITM1 NAMPT IRF1 IL1A ITGB3 HEL-S-78p CXCL10 FOS ATF3 CXCL11 QRFP ANGPTL4 EDN1 FGA TRAF1 CCL20 RGS2 DUSP10 HCAR2 TNC CCL22 TNFAIP3 BCL2A1 IFIT1 RELB IFIT3 IFIH1 IGFBP1 IFIT2 VTN ISG20 HELZ2 CEBPD IL11 TNFRSF21 ISG15 IL1B BIRC3 ACHE HRH1 JUN EGR1 KLF6 LIF MAFB CXCL2 PTGS2 GBP1 MT2A RHOB NFKBIA CISH GJA1 LBP PMC6944711__F3 Functional intersection of the GPCR-senescence system TES JUN MAF GRK1 PMC3480664__F1 Neurotrophin Regulation of Energy Balance in the Adult CNS and PNS CNTF CRH POMC NPY ARC AgRP BDNF PMC8666469__F3 Baricitinib combination therapy: a narrative review of repurposed Janus kinase inhibitor against severe SARS-CoV-2 infection STAT3 IL19 STAT1 EGF IL10 STAT2 IF2D STAT4 IL6 JAK1 TYK2 PMC3118279__F2 Ingenuity Pathway Analysis of epidermal genetic information retrieval-harvested melanoma specimens identifies overexpressed genes involved in melanocyte development and pigmentation PAX3 CRK KIT BCL2 GRB2 SOX10 SRC PMC4426221__F2 Schematic summary graph shows the postsynaptic effects of mGluR2/3 agonists on the regulation of both AMPA and NMDA receptors GSK3B CSK SNAP25 SRC PMC8098721__F1 Canonical and non-canonical Wnt signaling pathways DKK4 APC GSK3B LRP5 LRP6 RHO CTNNB1 DKK3 RNF43 DKK1 NOTUM BMP2 ZNRF3 DKK2 CCND1 WIF1 PMC6305219__F1 Cdon, Boc, and Gas1 act as positive regulators of Shh signaling during optic vesicle formation CDON BOC SHH SMO GAS1 PMC6915081__F7 The possible mechanism of sotetsuflavone inhibited progression of non-small cell lung cancer BAX MTOR ATG5 PMC11693700__F8 Key proteins in the HIF, ferroptosis, PI3K/AKT/mTOR, and p53 signaling pathways are subjected to ubiquitination modifications by deubiquitinases and E3 ubiquitin ligases FBXW7 TRIM47 GPX4 RBCK1 BAP1 USP46 USP37 MTOR OTUD1 NOX4 VHL PMC11693700__F7 Deubiquitylase in the p53 signaling pathway signaling pathway TRIM47 RBCK1 MDM2 MTOR PMC11693700__F6 Deubiquitylase in the PI3K/AKT/mTOR signaling pathway signaling pathway FBXW7 ZNRF1 USP46 PTEN SLC7A5 OTUD1 VHL LZTFL1 PMC11693700__F5 BAP1 in the Ferroptosis signaling pathway GPX4 BAP1 SLC7A11 HEL-S-64p VHL PMC2815132__F1 Dopamine Synthesis Pathway: Dopamine’s synthesis pathway begins with the amino acid tyrosine and is regulated by the activity of tyrosine hydroyxylase TH PNMT DBH PMC11693700__F4 VHL and Beta-TrCP in the Ferroptosis signaling pathway BAP1 USP37 VHL PMC11693700__F3 BAP1 and USP37 in the HIF signaling pathway EMP1 HILPDA NOX4 PMC3829308__F1 Interferon beta signaling pathway IFNAR2 IFNAR1 TYK2 PMC3683326__F3 GenMAPP schematic of cell cycle pathway genes CDK7 PCNA PI3 CDK2 MYT1 SKP2 CA14 PMC3784533__F1 Emerging concepts in immunity to hepatitis C virus infection SOCS1 CD81 TBK1 MAVS IRF3 IRF7 SOCS3 TRAF3 CXCL10 TLR3 IFNAR1 LDLR JAK1 TYK2 CLDN1 PMC7798030__F2 p21 is regulated by multiple pathways KLF4 SOX6 PCNA USP11 KLF5 ECRG4 PMC6545597__F1 Proposed model showing the interactions of Nm23-H1 with cellular pathways CDC42 OBI1 RHO PMC6085137__F1 FOXO1 regulates activation and function of dendritic cells CD80 RICTOR FOXO1 CCR7 MTOR PMC3381238__F1 Schematic representation of APP processing and role of its products in AD pathology ACHE MED12 APP PMC4990059__F2 Canonical Wnt signalling pathway APC GSK3B CTNNB1 PMC2783967__F6 Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin GAL CRAT FASN FADS2 CYP1B1 FADS1 INSIG1 ALOX15B ELOVL3 NR1C1 THRSP HSD3B1 NR3A2 LPIN1 SOAT1 KIN PMC10885964__F2 Advancements in Genetic Marker Exploration for Livestock Vertebral Traits with a Focus on China TF SMAD1 THSD4 IGSF1 SMAD2 EMP3 SMAD4 NODAL BAMBI IFNG E2F4 FST BMP4 HDAC2 THBS1 TFR2 SIN3A SMAD6 ARHA PITX2 SKI HFE2 HDAC1 RBX1 BMP2 NEO1 SKP1 HFE PMC8615223__F1 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights CSF2 COX1 KEAP1 TLR4 NQO1 GSK3B IL4 IRAK1 MTOR TRAF6 IRAK4 MYD88 PMC5505220__F3 Modeled mechanism by which FSH via PKA inhibits MKP3/DUSP6 to promote the accumulation of phosphorylated ERK in preantral GCs EGFR GRB2 FSHR PMC8505973__F1 Resistance to Hypomethylating Agents in Myelodysplastic Syndrome and Acute Myeloid Leukemia From Clinical Data and Molecular Mechanism CD40 CD80 NSUN3 CDA MSC VCAM1 TRAF6 CDK9 PMC5567910__F8 A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development FOXF1 BMP4 SHH SMO PMC8615223__F6 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights KEAP1 TLR4 GSK3B PTEN MTOR PMC8615223__F5 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights CDC2 BAX BAD FAS CDK6 CDK2 BCL2 APAF1 CDK4 FADD PMC8615223__F4 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights BAD GSK3B BCL2 PTEN MDM2 MTOR PMC8615223__F3 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights CDC2 BAX BAD FAS EGFR PTEN HIF1A MTOR IRS1 RHEB TSC2 TSC1 CDK6 COX2 CDK2 BCL2 MDM2 GRB2 APAF1 CDK4 FADD PMC5946330__F7 Proposed role of TGFB1 signaling in HASM cell shortening and hyperresponsiveness C2 SMAD2 SMAD4 ARHA PMC6156841__F1 Human Disease Phenome construction HTRA2 PINK1 NDUFA9 LRRK2 HEL-S-67p NDUFV2 SNCA NDUFS8 PSEN1 SNCAIP SDHA PSENEN PSEN2 APP PMC10960765__F2 Ubiquitination enzymes in the Wnt/Beta-catenin signaling pathway of CRC RNF146 RNF43 APC ZNRF3 UBE2S SMURF2 TRIM29 CTNNB1 PMC11545986__F3 Circadian dysregulation of lipid metabolism and adverse pregnancy outcomes LPA PER3 PER2 CRY2 ACADVL CPT1A PMC7603577__F9 Relaxin signaling pathway in the treatment of gout and hyperuricemia with plantain TGFA RXFP3 MMP2 MMP9 PMC9540480__F1 Applying Modeling and Simulations for Rational Dose Selection of Novel Toll‐Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need TLR8 IRF7 TLR7 PMC7603577__F7 IL-17 signaling pathway of plantain in the treatment of gout and hyperuricemia IL17RC TRADD COX2 TAB3 IL17RB GSK3B MMP9 TRAF6 FADD PMC7956553__F3 Simplified cartoon of potential crosstalk between activated canonical Wnt/Beta-catenin and mTORC1 pathways TSC1 GSK3B MTOR CTNNB1 EIF4E PMC4197875__F2 Hippo signaling pathway in stem cell biology and cancer LATS1 CDX2 LATS2 AMOT HAND1 NF2 CTNNB1 GATA3 PMC7956553__F2 Cartoon of major proteins in the wingless-related integration site (Wnt)/Beta-catenin growth pathway RNF43 APC LRP5 ZNRF3 LRP6 GPR49 CTNNB1 PMC4197875__F1 Hippo signaling pathway in stem cell biology and cancer PAX3 FAT4 TAOK1 RASSF6 TAOK2 SIK1 PATJ SIK3 ZYX MARK4 RHO MARK1 LATS1 MOB1A FRMD6 LATS2 AMOT SIK2 TAOK3 SCRIB NF2 FAT2 FAT3 PMC6406015__F1 Regulation of B cell receptor (BCR) signaling on B cell survival SYK CD79B BAD CD79A RASGRP3 CARD11 MCL1 GSK3B CD19 CAP2 BTK BCL10 BCR BCL2 CAP1 PMC7956553__F1 Cartoon of major proteins in the mechanistic target of rapamycin (mTOR) growth pathway RHEB TSC2 TSC1 EIF4E PMC5539260__F7 Overview of the pathogenic model of C. difficile infection SYK NOX5 SCARA3 EGFR CD46 REL PMC4197875__F4 Hippo signaling pathway in stem cell biology and cancer TG CTNNB1 PMC11788642__F8 Schema of Rnf111 regulating the development of hematopoietic stem and progenitor cells by maintaining Smad2/3 phosphorylation and activating the Gcsfr/NO signaling pathway SMAD2 SMAD4 CEBPB PMC4197875__F3 Hippo signaling pathway in stem cell biology and cancer LATS1 LATS2 NF2 PMC11356930__F5 MEHTCMPs on intestinal flora TLR4 TNF MYD88 PMC11356930__F4 MEHTCMPs on the NLRP3 signaling pathway NLRP3 TLR4 MYD88 PMC11356930__F3 MEHTCMPs on the MAPK signaling pathway STAT3 STAT1 RAF1 IRAK1 GRB2 TRAF6 LBP IRAK4 MYD88 PMC7956553__F4 Cartoon of mTORC1, Wnt/Beta-catenin, and estrogen receptor A (ERA) molecular pathway interplay in the female-specific, Tsc2-null, rare lung disease lymphangioleiomyomatosis (LAM) CCND2 WNT3A GSK3B LRP5 LRP6 CTNNB1 PMC11356930__F2 MEHTCMPs on the signaling pathway of TLRs TLR4 CD14 IRAK1 PSG1 TRAF6 MYD88 PMC8064164__F1 Role of cannabidiol in Parkinson’s disease by targeting the WNT/Beta-catenin pathway, oxidative stress and inflammation APC GSK3B LRP5 LRP6 CTNNB1 PMC6746018__F1 PI3K/Ras signaling pathway CBL SOS1 NF1 BRAF GRB2 MTOR PMC9139230__F1 How Phosphofructokinase-1 Promotes PI3K and YAP/TAZ in Cancer: Therapeutic Perspectives ACLY SOS1 HEL-S-133P F2 HK2 EGFR ARHA MTOR CTNNB1 PMC5539260__F5 Host/pathogen cross-talk mechanism through core pathways at the early stage of C SYK STK11 ARRB2 SCARA3 LRRK2 COPS5 PTEN YY1 ARHA RAC1 HEL-S-125m RPS3 PAK1 GRB2 TSPAN7 PMC8358930__F1 Biological Significance of YAP/TAZ in Pancreatic Ductal Adenocarcinoma LATS1 LATS2 PMC9258583__F8 Determinants of RPA megafoci localization to the nuclear periphery in response to replication stress CRB2 RAD51 CDS1 INO80 PMC8874408__F6 3, 3′- (3, 5-DCPBC) Down-Regulates Multiple Phosphokinase Dependent Signal Transduction Pathways in Malignant Melanoma Cells through Specific Diminution of EGFRY1086 Phosphorylation STAT3 EGF STAT5B STAT2 EGFR GSK3B ATM MTOR SRC CTNNB1 PMC9713001__F2 Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma GOT2 GLS HEL-S-133P HK2 GFPT1 SLC7A5 PMC10759355__F1 Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability TLR4 AGA MYD88 PMC5982750__F5 SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand CYP2C8 CYP3A4 ABCB1 PMC9713001__F4 Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma STAT3 SLC3A2 ATG3 GPX4 ULK1 SMAD4 SLC7A11 MTOR KRAS PMC5982750__F4 SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand CES2 CES1 APC ABCB1 PMC9713001__F6 Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma SOCS1 STAT3 JUNB SMAD2 SMAD4 BNIP3 UCP1 PTEN SOCS3 VHL TGFBR2 HOXA1 STAT1 FOXO1 TFAP2C ZEB2 CEBPB SOCS6 PMC5982750__F1 Fluoropyrimidines pathway DPYD TYMS PMC9072012__F3 CTNNB1 in Endometrial Cancer APC GSK3B CTNNB1 PMC3145575__F3 CSR pathways for primary non-HCC hepatocytes and HCC (Huh7) cell types IFNG TGFA INA DAP NLK MTOR PMC5982750__F3 SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand ERCC1 HEL-S-22 PMC6019481__F10 Estrogen signaling pathway PIK3CA GNAO1 RAF1 SHC1 MAPK13 SOS1 EGFR PIK3R1 GABBR1 GNAS KCNJ3 MMP2 ATF4 SRC CREB1 CALML3 MAPK1 GNAI1 JUN SP1 OPRM1 KRAS FOS HRAS FKBP4 HBEGF PLCB1 GPER CALM1 MAP2K1 GRB2 PMC6122186__F1 Hippo signaling pathway LATS1 LATS2 PMC6122186__F2 Simplified illustration of YAP/TAZ and glycolysis OGT FOXC2 HK2 PMC2729314__F2 Wnt signaling network STOM APC LRP6 RHO CTNNB1 PMC5621106__F1 Double-strand break (DSB) repair pathway choice DNA2 WRN BLM PMC3671630__F1 Nucleotide excision repair ERCC1 XPA DDB2 DDB1 PCNA UVSSA POLK POLE XPC PMC7986633__F4 Proposed model of how deflavination of ACAD9 by ECSIT permits the coordinated regulation of the FAO and OXPHOS pathways ECSIT ACAD9 C2 NDUFAF1 PMC3109492__F2 Intestinal Effector T Cells in Health and Disease IL25 TSLP FOXP3 PMC8129117__F6 Proposed model of ROS generation and regulation of survival signals in CLL cells BTK AXL BCR LYN MTOR PMC7402427__F8 Summary for nuclear and cytoplasmic roles for EZH2 during osteoclastogenesis MAFB EZH2 MTOR PMC1828067__F7 Osteopontin/AvB3 signaling in the regulation of prostate cancer cell migration CD44 RHO SRC PMC11824814__F8 Dietary DHA Regulated the Androgen Production in Male Chinese Tongue Sole Cynoglossus semilaevis HSD17B3 STAR HSD3B1 HSD11B2 HSD17B1 HSD17B2 PMC11491976__F3 PI3K/AKT/mTOR signaling pathway RHEB EGF EGFR IGF1R IRS1 PMC11491976__F2 PI3K and PIP2-mediated pathway MTOR PCK1 PMC4766410__F5 Extracellular calcium-sensing receptor regulates human fetal lung development via CFTR CASR CLCA1 CLCN2 CFTR PMC8770601__F2 Effect of oxidized lipids of function of myeloid cells in cancer CD36 MPO PMC8770601__F1 Major metabolic pathways leading to the formation of signaling molecules from PUFA-GPL and pGPL LOX COX2 MEN1 MPO PMC7941238__F2 Mechanisms by which ADSCs‐EXOs may promote wound healing CDH2 PCNA RBP4 MMP3 PMC4552732__F4 A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung ASAH2 SPTLC3 NSMAF SGMS2 PAH PMC6749995__F4 Lung microenvironment: an important regulator of tumour growth and metastasis CCL3 CXCL5 S100A8 CCR2 MMP9 CCL5 TNF CCL2 CR1 PIGF ALOX5 TLR4 CCL4 IL8RB S100A9 IL1B PMC5571607__F2 DAMP/ TLR/ inflammasome interactions CD44 HMGB1 NLRP3 TIRAP TLR4 IRAK1 IRF3 IRAK2 IRF7 TRAF6 MYD88 PMC6503994__F8 Potential role for TXNIP in HG-mediated RPE dysfunction RPE NLRP3 TXNIP PMC5395201__F3 Inactivation of Retinoblastoma Protein in Uveal Melanoma by Phosphorylation of Sites in the COOH-Terminal Region CDK6 CDK2 CDK4 PMC5824774__F5 Result of ‘Networks’ query way MAX EGF TGFA ARHG SHC1 LAT RNF4 EGFR MYC IL6R NRG4 STUB1 ERBIN TFF2 TFF1 EREG ADAM17 NRAS RND1 UBB REST ERBB4 CUL5 RPS27A IL6 RAC1 LRPPRC ERBB3 HRAS SEMA4D NRG2 RHOB MAP2K1 CDC37 GRB2 PMC7527574__F1 Therapeutic targeting of HGF/c-Met pathway BAD HGF AXL MTOR SRC PMC8144308__F1 Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics RORA PMC8012701__F2 Lipid metabolisms change in dormant cancer cells ACSS2 HMGCR ACSM3 SCD MSMO1 SREBF2 MYLIP TM7SF2 LBR PMC4576413__F3 Redox control of protein degradation RBX1 KEAP1 IL1B VHL PMC3983080__F1 Multiple Model-Informed Open-Loop Control of Uncertain Intracellular Signaling Dynamics ZAP70 PLCG1 LAT ITK GRB2 LCK PMC6108937__F3 Androgen receptor signaling R promotes diverse metabolic processes ACLY FASN ACACA PMC2576041__F9 The role of the IGF-1/phosphatidylinositol 3-kinase (PI3K)/Akt pathway and atrogin-1 and MuRF-1 in SI-induced atrophy and in the amelioration of atrophy by high-load isometric contractions SI MTOR IRS1 PMC1574111__F3 Proposed mechanism for FK506-potentiated neurite outgrowth CDC42 NGF GRB2 PMC8144308__F2 Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics RCAN1 PMC6788940__F2 Targetable pathways in ESR1 mutant cells identified in preclinical studies CDK7 IGF1 CDK2 IGF1R MTOR PMC9406846__F2 Clinical and Molecular Implications of Osteopontin in Heart Failure TF CD44 OGDHL PMC5940273__F3 Repressing the repressor: Ezh2 mediates macrophage activation SOCS3 TRAF6 MYD88 PMC6500576__F2 Melanocortin pathway and control of appetite- progress and therapeutic implications STAT3 OCA2 FOXO1 ROCK1 TRPC5 PMC6675248__F1 Various molecular inhibitors and stimulators in mTOR signalling pathway RHEB EIF4B SGK1 NF1 TFEB TTI1 PTEN RHO DEPTOR EIF4E PMC6675248__F3 Role of mTOR signalling pathway during protein translation MTOR ELF3 EIF4E PMC6675248__F2 Cell signalling dysfunction in mTOR signalling pathway leading to syndromic and idiopathic autism RHEB TSC2 TSC1 EIF4EBP1 NF1 PTEN PMC9390702__F1 Targeting KRAS: Crossroads of Signaling and Immune Inhibition CDK6 SOS1 EGFR MTOR CDK4 PMC7541823__F5 Pathway of phagosome biogenesis, maturation, and phagolysosome fusion for efficient clearance of Mtb SNAP23 RILP ESX1 MTMR3 ARF6 PTPA EEA1 CD63 M6PR RAC1 PMC7541823__F1 Receptors implicated in the internalisation of Mycobacterium sp NLRP3 TLR3 CD36 APC ELL TLR9 CD14 NOD2 AIM2 IFI16 MARCO CR1 PMC10963452__F4 Schematic plots illustrate the signaling mechanism of other organokines in intervertebral disc cells ANGPTL8 ANGPTL4 GHSR FSTL1 KEAP1 GSK3B MAF TFEB MTOR PMC4788929__F6 MELK and stathmin signaling GRB2 SHE PMC10963452__F3 Schematic plots illustrate the signaling mechanism of various osteokines in intervertebral disc cells CXCR1 SPARC SHH IL8RB CTNNB1 PMC6054915__F6 Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells MOG MBP APC TEF PMC10963452__F2 Schematic plots illustrate the signaling mechanism of various adipokines in intervertebral disc cells C6 STAT3 CMKLR1 APPL1 ADIPOR1 ADIPOR2 LEPR ARHA SIRT1 CTNNB1 MYD88 PMC8305053__F1 Mutations in TSC Genes on Neurodevelopment and Synaptic Transmission RHEB TSC2 RICTOR TSC1 PTEN MTOR TNF IRS1 PMC5400646__F8 Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor B signaling pathway HEL-S-99n HEL-S-130P S100A6 PRDX5 EIF4E PMC4260148__F3 Details of genes in the ‘acute phase response’ biological pathway identified in Ingenuity Pathway Analysis, which are differentially expressed in the frontal section of SHRSP vs. WKY rats at 5 weeks of age CRP F2 FGA HP MTOR PMC7541823__F7 Antigen presentation, T‐cell responses and activation of the cytosolic surveillance pathway (CSP) in the case of Mycobacterial infection of APCs CGAS CD1A CD1C IRF3 B2M PMC8539333__F1 Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence CYP1A2 STAT3 BAX PTEN CYP1A1 GPX1 CCNE1 NLRP3 AHR CDK2 CYP3A4 CCND1 CDK4 PMC9039735__F3 Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns NRK PARP4 NAPRT NMNAT1 NAMPT NMNAT2 PARP2 PARP1 NMNAT3 PMC8708448__F4 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective KIF7 SUFU SMO GLI3 PMC3844392__F1 Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses BAX ATF3 TSC2 BNIP3 PTEN TIGAR MDM2 APAF1 PMC8708448__F3 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective LATS1 BMI1 LATS2 CCNE1 PTCH1 CCND1 YAP1 PMC7676498__F2 The Microenvironment in Controlling the Fate of Bioprinted Stem Cells EGF HGF SMAD2 SMAD4 MTOR CTNNB1 PMC8708448__F2 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective CCND3 MAML1 CDKN1A ERBB2 NRARP MYC PMC8708448__F1 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective CD44 WLS BCL9 MMP7 PPARG DKK1 LRP5 LRP6 TNIK CCND1 HNF1A CTNNB1 PMC12171307__F3 Common regular pathways of ncRNAs STAT3 MYB CXCL12 CCL18 SMAD1 DKFZp781O1323 HEY2 AKT3 SMAD2 SMAD4 PTEN MTOR CTNNB1 PORCN CDH2 SLPI E2F2 PSMB8 ALX4 LRP6 PARD3 CRABP2 HAS2 CDK2 TNIK PMC11910855__F8 Schematic diagram illustrates the impact of targeted activation of ErbB4 receptor on hippocampal neuronal damage, neuroinflammation, and cognitive functions in mice exposed to PS-MPs SIRT3 NLRP3 ERBB4 DOCK3 SYP TLR4 SYT1 PMC12171307__F1 EMT and Tumors STAT3 BRCA1 EGFR AKT3 VEGFA PRRX1 SRC PMC3335376__F8 Therapeutic modulation of the TP53 pathway STAT3 ATR WRN PML JMY PTEN MIF IL6 BLM MTBP MEI1 ATM MDM2 SOX4 TDG FADD PMC4227160__F4 Proposed model of the roles of CDKN1A and KIF20A in cell cycle control via RB/E2F pathway ATR CDK6 CDKN1A KIF20A CDK2 ATM CENPE CDK4 PMC3335376__F4 Illustration of p53 TIAs in lymphocytes BAX CASP9 BAD MEI1 CASP3 ME1 MTOR PMC4747358__F3 Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicine GPR137B PROP1 MTNR1A AVPR1B SPRR3 GALR3 MYC UNK CTNNB1 RXFP2 PMC9406846__F4 Clinical and Molecular Implications of Osteopontin in Heart Failure ATR MTOR PMC8923702__F7 Mannan-Binding Lectin Regulates the Th17/Treg Axis Through JAK/STAT and TGFB/SMAD Signaling Against Candida albicans Infection STAT3 SMAD2 JAK3 SMAD4 SOCS3 PMC3737294__F1 Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance GLUD1 GOT2 MAL ME1 CIT PMC2714846__F6 Estradiol-17B, prostaglandin E2 (PGE2) and the prostaglandin E2 receptor are involved in PGE2 positive feedback loop in the porcine endometrium PTGER2 PTGS2 PMC11695279__F4 M6A-mediated tumor regulation in the immune microenvironment CD40 STAT3 CD80 IGF2BP3 JUNB YTHDF1 SLC16A3 TLR4 ALKBH5 METTL14 METTL3 IL8RB IGF2BP2 PMC12179417__F6 Endoplasmic reticulum stress promotes the immunosuppressive activity of M2 macrophages and myeloid‐derived suppressor cells to enhance tumor immune escape STAT3 NOS2 SIRPA ARG1 ATF4 XBP1 CD47 PMC12179417__F5 Endoplasmic reticulum stress affects the function of dendritic cells and T cells, leading to immune evasion ATF4 ERO1A XBP1 PMC5989534__F10 Schematic summary showing how VPS35 might regulate LRRK2 and LRRK2 protein kinase activity and hence PD VPS29 VPS35 LRRK2 PMC9004553__F8 Construction and evaluation of a nomogram for predicting survival in patients with lung cancer DBF4 TRIP13 CDC20 BUB1B CDC6 HMMR CKS2 MYBL2 RRM2 UBE2S EZH2 SKP2 UBE2T PTTG1 BIRC5 SPC25 CDCA3 TK1 CDKN3 SPAG5 TOP2A PMC12179417__F4 Endoplasmic reticulum stress on antigen–MHC‐I complex and natural killer cells MICA ATF4 XBP1 PMC3656827__F2 Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury: a review JAK3 JAK1 PMC4978167__F1 Integration of Endothelial Protease-activated Receptor-1 Inflammatory Signaling by Ubiquitin TH ARHA RHO PMC9611148__F3 STING in Non-Alcoholic Fatty Liver Diseases: Potential Therapeutic Targets in Inflammation-Carcinogenesis Pathway TBK1 CGAS IRF3 PMC3514733__F1 Chemotactic signaling pathway in sperm GC HEL-S-11 PMC9611148__F2 STING in Non-Alcoholic Fatty Liver Diseases: Potential Therapeutic Targets in Inflammation-Carcinogenesis Pathway CGAS IRF3 EIF2A PMC6679869__F1 The role of inflammasomes in lupus nephritis TLR4 TLR8 AIM2 IFI16 PMC2721475__F1 Downstream targets of IGF-1R TSC2 TSC1 GRB2 MTOR IRS1 PMC8622815__F1 AHR Ligands in Skin Homeostasis and Cutaneous Inflammation TF AIP AHR PAH AHRR SRC PMC7585866__F2 Pathogenesis of renin-angiotensin system in acute lung injury caused by viral infections TMPRSS2 ACE2 PMC7585866__F1 Diagram of regulatory mechanism of renin-angiotensin system (RAS) ACE2 PMC10949864__F3 Mechanisms for the extracellular acidification inducing alterations of Ca2+ fluxes TRPC4 TRPC1 TRPV1 TRPC5 CNP GPR4 PMC9384336__F5 Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method TBK1 TLR9 IRF3 IRF7 TRAF3 TRAF6 IRAK4 RAC1 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC9437842__F4 GRPR neural and signalling pathways GRPR ITCH NPY1R NPY PMC10949864__F2 Cancer-associated alterations of Ca2+ fluxes at acidic tumor microenvironment and targets STAT3 PGP CPZ RAF1 SGK1 TRPC4 TRPC1 TRPV1 TRPC5 ARHA CTNNB1 ROCK1 EIF2A ABCB1 PMC4403492__F1 HPV carcinogenesis RB1 UBE3A KDM6B TERT MDM2 CDK4 PMC5532627__F2 Linking processing of clustered DNA damage and immune response HEL-S-92n FEN1 ATM CCL2 PMC4005972__F4 Proteins involved in the BCR signaling pathways BAD PAG1 MTOR ARHA RAC1 CDK6 FYN BCL10 PLCG2 CSK LYN BIK CDK4 PMC10378342__F2 Intravenous Immunoglobulin in Kawasaki Disease—Evolution and Pathogenic Mechanisms NLRP3 TRAF5 IL18 IL1B PMC3735686__F1 Nucleotide excision DNA repair pathway as a therapeutic target in patients with high-risk diffuse large B cell lymphoma ERCC1 XPA RCC1 PCNA POLE PMC8907745__F2 Molecular Brakes of Adipose Tissue Lipolysis PDE3B EGR1 PNPLA2 IRS1 PMC8907745__F1 Molecular Brakes of Adipose Tissue Lipolysis PPARG TG PLIN1 G0S2 HILPDA PMC7290982__F1 GD T cells activation IPP APC MICA MICB PMC7968373__F1 Swimming towards solutions: using fish and frogs as models for understanding RASopathies CBL SPRED1 NF1 SHOC2 GRB2 PMC199174__F9 Models for the function of Ser307 phosphorylation IGF1 GRB2 IL1B PMC2533145__F10 Rap1 and glycolytic/TCA cycle reaction ENO2 ADH6 HEL-S-49 ENO1 HEL-S-4 PMC4592441__F4 Myc-regulated metabolic pathways in cancer ACLY GLS HEL-S-133P MYC PMC10158029__F12 The regulator mechanism of S100A16 in Glioma LATS1 CUL4A S100A16 PMC11699442__F4 Dietary acrylamide on kidney and liver health: Molecular mechanisms and pharmacological implications BAX IL6 MTOR PMC11763285__F5 Regulatory pathways controlling cell proliferation and differentiation CDC42 INF2 PAK1 RIT1 COQ6 NF2 MTOR PMC8324353__F6 Antitumor Effect of Lenvatinib Combined with Alisertib in Hepatocellular Carcinoma by Targeting the DNA Damage Pathway ATR BRCA1 BRCA2 ATM SSB CDC25B PMC6201924__F4 Proteomic analysis of Lactobacillus casei GCRL163 cell-free extracts reveals a SecB homolog and other biomarkers of prolonged heat stress RPE AIDA PMC4190558__F1 Repair of oxidative DNA lesions by the MMR pathway RAD18 MSH6 MLH3 LIG1 MSH2 PMS2 PCNA MUTYH PMC4629217__F2 Roles of FXR in regulating lipid and glucose metabolism LPL TIEG2 FAS NR1C1 HEL-S-62p C2 APOB PMC156758__F1 NEW EMBO MEMBER’S REVIEW IL4 IL2 TRAF2 PMC6909742__F2 NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology DUOX1 DUOX2 NOX4 PMC7696043__F1 Nuclear factor-kappa light chain enhancer of activated B cells (NFKB) pathways LTB LTA RELA RELB PMC5084660__F3 Putative molecular pathway that links GSK3B activity with the resistance of pancreatic cancer cells to DNA damage induced by gemcitabine and ionizing radiation CDK6 GSK3B MGMT CDK4 CTNNB1 PMC6909742__F5 NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology TF HDAC1 HDAC2 PMC5380843__F8 Proposed model for activation of IFN by doxorubicin bypassing IFN antagonism by Ebola virus VP35 protein TBK1 CGAS MAVS ATM IRF3 IRF7 TOP2A PMC5078034__F8 Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy BAX ATR CDK6 CDK2 BCL2 MDM2 CCND1 CDK4 PMC9631451__F8 Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer MAPK1 CASP9 JUN MAPK11 GSK3B BRAF GNAL PTGS2 VEGFA IL6 TNF MAPK8 PRKCB IKBKG IKBKB PRKCA CASP3 MAPK10 EP300 MAP2K1 CCND1 PMC6696055__F2 Regulation of autophagy by ROS ULK1 ATG14 ATM PTEN ATG5 PMC7459008__F1 PI3K-Akt pathway mediated antiviral mechanism in silkworm Antheraea mylitta SHB SGK1 GRB2 PDK2 MTOR IRS1 PMC7843495__F3 Mitochondria-related core genes and TF-miRNA-hub mrDEGs network in breast cancer TH LIPE PMC7493965__F10 Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-tomesenchymal transition TIMP3 TRAF3IP2 RECK MMP2 IL1B PMC6443597__F8 miR-4739/BMP-7/Smad1/5/9 pathway induces pleural fibrosis SMAD9 SMAD1 COL1A1 DKFZp781O1323 SMAD2 SMAD4 BMP7 PMC8121554__F6 Isoquercitrin protects HUVECs against high glucose-induced apoptosis through regulating p53 proteasomal degradation BAX BCL2 PMC4292169__F1 The meiotic recombination pathway SPO11 MRE11A PMC6218458__F1 Canonical Wnt pathway and the role of the LRP6 receptor DKK1 APC LRP6 CTNNB1 PMC5845557__F2 Invariant NKT (iNKT) cell activity within the tumor microenvironment (TME) IFNG APC CD1D PMC1955758__F2 How both apoptotic death and immunity may be triggered by dsRNA BAX BAD FAS RNASEL RAC1 FADD PMC11828848__F4 Enzymes of energy metabolic pathways divergent in UGT2B17-deficient livers HEL107 UGGT1 H6PD PC GCK PMC3555518__F1 Mechanism of miRNA expression and/or function perturbation FUS DDX5 DGCR8 DROSHA PMC3079374__F1 Simplified schematics of the MAPK and PI3K pathways in melanoma and the clinical compounds available for their inhibition ARAF RICTOR BRAF PTEN MTOR PMC6957369__F3 Core analysis of genes differentially regulated by SP-D nitrosylation MMP7 NOS2 FAS SELE MMP10 TNFSF6 IRF1 IL2RA CXCL2 CD40LG PTGS2 IL1A TNF MYD88 VCAM1 GADD45A CCL20 SELP IL1B PMC6781692__F1 Shh signaling pathway in hepatocellular carcinoma CHSY1 SNAI1 SUFU SHH BCL2 SMO GLI3 PMC6989408__F5 Mitochondria-associated ER membranes in normal versus cancer cells VAPB MFN1 PACS2 MFN2 TMX1 PMC3298638__F2 Screening for small molecule inhibitors of embryonic pathways: Sometimes you gotta crack a few eggs BCL9 MAML1 LRP5 LRP6 SMO CTNNB1 PMC6627123__F5 Involvement of FGFR4-related signaling pathways CRK SHB FRS2 CYP7A1 PTEN GRB2 MTOR SRC PMC12217889__F4 Crosstalk Between the C1 Subpopulation and EndoCs, ECs, and Macrophages MDK CXCL12 PTN ACKR3 PMC3989895__F2 Simplified pathway map of CCN1 and CCN2-dependent outside-in signaling pathways regulating endothelial cell function and behavior CDC42 ASB1 LRP4 CYR61 RAF1 EGFR LRP5 LRP6 CCNI LRP3 BMP4 SRC CTGF PMC4850435__F6 Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions CD40 CXCL9 CD80 TIRAP CCL3 TLR9 CCL5 MYD88 LY96 TLR4 TLR8 TLR7 IL1B CASP8 CD14 TLR5 IL6 CXCL10 RAC1 CXCL11 TLR1 TLR3 CCL4 LBP FADD PMC6117946__F3 Non-enzymatic Krebs cycle-like reactions that occur in the presence of peroxydisulfate and FeS form a network that closely mimics the typical (oxidative) Krebs cycle and the glyoxylate shunt MAL FES CIT PMC8438071__F8 In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy BAX REN PARP1 PMC6006503__F1 Role and molecular pathway of IL-32 in cancer STAT3 IL1B CTNNB1 PMC12172856__F7 Interaction network of key signaling pathway-mRNA-miRNA CDC42 ACVR2B MAP3K1 SNAI1 FST BMP4 GDF15 RASGRF2 RPS6KA1 ZEB2 IRS1 PMC7169114__F2 Long noncoding RNAs (lncRNAs) regulate innate immune responses through activation of RIG‐I and via deregulation of epigenetic mechanisms TLR4 RELA CCL5 PMC8004488__F8 Astrocytes morpho-functional alterations in ADLD phenotype CTRL STAT3 LIF PMC6349383__F3 Summary of the oncogenic pathways genetically disrupted in the UM-SCC oral cavity cell line panel CASP8 LTBR KEAP1 EGFR PTEN IGF1R MYC CTNNB1 RB1 CDKN2A CDK6 FGFR1 TP63 NFE2L2 ERBB2 FAT1 FGFR3 CCND1 NOTCH1 PMC8125319__F2 Senescent Cells in Acquired Drug Resistance and Secondary Cancer in BRAFi-Treated Melanoma BRAF PTEN MTOR PMC64750__F4 Metabolic pathways related to cell-wall formation CAD PMC4033425__F3 Cell-cell coupling in the somitogenesis clock IFNG SI LFNG PMC2718282__F8 The role of Mal connecting PI3K to TLR2/6 TLR1 MAL MYD88 PMC3069496__F1 miRNA biogenesis pathway AGO4 DGCR8 AGO1 AGO2 CCR4 DROSHA PMC6619735__F9 Proposed model illustrating the mechanism of arctigenin-mediated AB production inhibition and AB clearance promotion ULK1 BACE1 APP MTOR EIF2A PMC3395995__F1 Alloantigen presentation via the direct, semi-direct and indirect pathways following organ transplantation, and (B) the relative intensity of each antigen-presentation pathway during the post-transplantation (post-Tx) period APC REL PMC9586542__F6 Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease TG PC PMC3067333__F5 Schematic presentation of Nag PTS and parts of the central metabolism of R PDHA1 HPR PTS TNLG7C PMC5682418__F5 Selected miRNA-mRNA interaction networks involved in Jak-STAT signaling pathway STAT3 CNTFR CSF2RB PIM1 IRF9 MCL1 AIP BCL2 MTOR PMC7093977__F3 Phenotypic response of microglia on dietary fatty acid exposure TBR1 TREM2 LRRK2 TLR4 MYD88 PMC5682418__F4 Selected miRNA-mRNA interaction networks involved in T cell receptor signaling pathway ZAP70 LAT PAK4 CTLA4 IFNG ICOS CBL FYN BCL10 ITK GRB2 LCK CDK4 PMC7962119__F3 Cellular senescence (i.e., permanent cessation of cell division) is triggered by a variety of stresses CDK6 FOXO4 CDK2 BCL2 CDK4 PMC7037145__F3 Conflicting role of JNKs in dermal fibroblast biology COL1A1 COL1A2 TNLG7C PMC7697568__F1 Wnt signaling pathway RNF43 APC NOTUM GPR49 PMC7388440__F6 RA pathway model ROR1 GSK3B CTNNB1 PMC5702396__F1 Apoptotic Pathways in Glioblastoma BAX PTEN MDM2 PMC8450475__F1 Manifestations and Management of Hepatic Dysfunction in Congenital Disorders of Glycosylation ALG5 ALG12 SLC30A10 VMA12 ALG9 ALG3 TMEM165 VMA22 ATP6AP2 PMC10933834__F9 Biosynthesis pathway and gene cluster of erythromycin ACP2 PCCA ACP3 PMC8012461__F2 Biomaterials Regulate Mechanosensors YAP/TAZ in Stem Cell Growth and Differentiation TP73 HEL113 EGR1 ERBB4 GSK3B TBX5 AREG RHO MYC LATS1 LATS2 BTRC CSNK1E AMOT NF2 CTNNA1 PMC7697568__F3 Target therapies for ligand-dependent tumors RNF43 APC LRP5 LRP6 GPR49 PMC1584297__F9 Cross-talk between the NFKB and the STAT3 pathways STAT3 IL6 IL6R PMC10917541__F3 NMN-mediated longevity and the main reasons for decreasing NAD+ level with age TNKS SIRT1 PMC5833861__F2 Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies CD80 APC PMC5468379__F1 Viral RNA detection by RLRs and TLRs, signaling pathways and overview of FMDV strategies aimed at its supression TBK1 STAT1 MAVS TLR3 STAT2 IFNAR2 IFNAR1 TLR8 TANK IRF3 TLR7 TYK2 PMC9697406__F1 Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer ARID1A ATR YES1 PIK3IP1 MSH2 STAG1 EZH2 ANXA1 SLC7A11 TERT MTOR HDAC2 HDAC6 PMC4428707__F11 SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation TLR4 CD14 RAC1 PMC7802216__F5 Roles of palmitoylation during structural LTP CDC42 CDH2 LIMK1 ARHA PICK1 RAC1 PMC8273837__F4 Upregulation of receptor tyrosine kinase-like orphan receptor 2 in idiopathic pulmonary fibrosis CCND2 FOSL1 ROR2 LRP5 LRP6 SENP2 ARHA CCND1 CTNNB1 PMC3055758__F8 Mechanism of cAMP inhibition of MAPK activity VIP EGF SRC PMC5672329__F3 Outside-in signaling through class I PI3Ks TEC SYK RASA3 BTK SRC PMC8636777__F4 Weighted Gene Co-Expression Network Analysis and Treatment Strategies of Tumor Recurrence-Associated Hub Genes in Lung Adenocarcinoma CDC42 DLG2 VASP SYNPO PALS1 RHO MKX POPDC1 C2 RAB13 CFTR RAG1 GATA4 REL PMC9412801__F2 Clinical Utility of the Sivelestat for the Treatment of ALI/ARDS: Moving on in the Controversy? TLR1 TLR4 CD14 TRAF6 MYD88 PMC6274719__F1 Three apoptotic pathways (Extrinsic, intrinsic and granzyme pathways) GZMA SET FADD PMC7175142__F4 Influence of lipid mediators on ER stress-dependent pathway.Disorders in synthesis or action of exogenous factors, like lipid mediators (black) may lead to the generation and accumulation of abnormal proteins (AP) BCL2 XBP1 PMC6415584__F1 Pyruvate and glutamate are 2 major metabolic hubs in GSCs FAS GLS HK2 PC PMC3895844__F3 Dopamine-DARPP32 feedback in cAMP signalling is a significant canonical pathway in an olanzapine-treated hippocampus CREM OTP PMC7175142__F3 Influence of lipid mediators on the mitochondrial pathway COX2 HEL-S-28 PMC3895844__F2 Ephrin receptor signalling is the most significant canonical pathway in an olanzapine-treated cerebellum STAT3 CRK EGF FYN PXN KALRN HEL-S-11 ARHA PMC7753989__F6 Schematic model depicting the role of ADAM17/HB‐EGF/EGFR signalling pathway in directional collective migration of epidermal cells HBEGF ADAM17 EGFR PMC7175142__F1 Main apoptotic pathways TRADD BCL2 XBP1 FADD PMC4483595__F4 Proposed mechanism to explain the protective effect of CFHR1,3 deletion on the development of IgAN CFHR3 HEL-S-62p CFHR1 PMC4483595__F1 Three pathways of complement activation MASP1 C6 CD59 FH C7 HEL-S-62p C2 C9 C4A CR1 PMC9033378__F7 Psoriasis Vulgaris of Blood Heat Syndrome in Plasma Based on Widely Targeted Techniques HYI COCH PC CP PMC9033378__F6 Psoriasis Vulgaris of Blood Heat Syndrome in Plasma Based on Widely Targeted Techniques TF SLC3A2 STEAP3 FACL4 CP PMC8799876__F2 Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis TF PLG KDR PMC6247912__F2 Somatic mutations of the canonical signal transduction and tumor suppressor pathways in HCC CHD2 PMS2 SETD2 FANCB CHD9 FANCD2 SRCAP NF1 POLE MSH2 MSH3 EIF4H INO80 XPC EIF4E HRAS RHEB CHD4 TSC2 TSC1 BRCA1 SETMAR ERCC5 CHDH RET BRD2 TET2 ARID1A BRD7 TSHR EGFR CHD8 BRAF PML PTEN MTOR KMT2A TLK1 CHD5 MLL2 CHEK2 ATM PHF2 SETD1B SIRT6 EZH1 KMT2C EIF4B SMARCAD1 EIF1AX TET1 KRAS XRCC3 SMARCD2 JMJD1C CHEK1 ERBB2 SMYD4 CREBBP KDM5C KAT8 KDM4C PMC12027943__F5 Compound–target–pathway interaction network HEL-S-22 AURKA MMP12 EGFR DHFR GSK3B IGF1R TYMS MTOR PLK1 POR ALB ALDH2 PRKCE ADAM17 F10 FGFR1 CHEK2 PRKCA CSNK2A1 PDE4D MDM2 SRC TTPA CCND1 CCR1 HEL-S-72p PLG PTPN11 STS PARP1 NR3C2 PRKCI HMGCR HEL-S-130P CHEK1 HEL-75 PMC7680500__F6 Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine STK11 HEL-S-62p C2 EGFR PTEN ABCB10 CP PMC8066409__F2 Non-transcriptional activation of IRF3 by RIPA causes cell death BAX TBK1 CGAS MAVS IRF3 TRAF3 TRAF6 TRAF2 PMC3475405__F3 Blood–brain barrier (BBB) transport in homeostasis of brain AB APOE IL6 IL1B PMC2949529__F2 O-GlcNAc Signaling: A Metabolic Link Between Diabetes and Cancer? OGT GSK3B IRS1 PMC8066409__F1 Transcriptional and non-transcriptional activation of IRF3 by virus-activated signaling pathways lead to host antiviral response BAX TBK1 CGAS MAVS TLR3 EGFR IRF3 TRAF3 EIF2A SRC TRAF2 CTNNB1 PMC7426728__F2 DNA methylation regulates the PI3K/PTEN/AKT/mTOR signaling pathway in the resistance to therapy in cancer DNMT3B BAD TGFBI PTEN MTOR DEPTOR PMC7426728__F1 Activation of the Wnt/Beta-catenin signaling pathway in the resistance to therapy in cancer by methylation DKK3 APC GSK3B LRP5 LRP6 SFRP1 WIF1 CTNNB1 PMC7680500__F3 Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine PCK2 HEL60 FH IDH3B SUCLG2 OGDHL CS MDH2 PMC9675292__F1 Insulin Receptor Substrate Signaling Controls Cardiac Energy Metabolism and Heart Failure PDK4 F2 FASN PC GCK PMC7680500__F2 Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine HEL-S-133P PFKP HEL-S-162eP LDHB ENO1 HEL-S-30 ADH5 PMC5904231__F2 Process diagram indicating the p16INK4a/p14ARF–RB–p53 pathway in normal conditions ATR CHD5 ATM PMC6626430__F6 Proposed model illustrating the anti-IL-1B activity of matrine DDX19A NLRP3 DHX36 TLR4 IL1B MYD88 PMC9466978__F1 Decoding the Role of Familial Parkinson’s Disease-Related Genes in DNA Damage and Repair PINK1 LRRK2 BRCA1 SSB PMC5216946__F13 Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer IPP SP1 HMGCR RHO PMC3612034__F3 Identifying Resistance Mechanisms against Five Tyrosine Kinase Inhibitors Targeting the ERBB/RAS Pathway in 45 Cancer Cell Lines EPCAM LGALS8 CD9 PMC6627955__F4 Sphingolipids (SLs) together with the responsible key genes involved in regulating the pathway UGCG FAS CERK SCD FASN FADS2 GCK PCK1 PKLR FADS1 PMC9218363__AF1 Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A MTOR FADD EIF4E PMC10374032__F1 Genome-scale metabolic modeling and in silico analysis of opportunistic skin pathogen Cutibacterium acnes HMBS RPE HACD1 MME PIG59 MAL CS ME1 COA4 DSC1 CIT PMC4612707__F5 Quantitative analysis of transcriptional levels of genes in the xylose metabolic pathway and the central carbon metabolism pathway HEL60 tal-1 ENO2 HEL-S-68p HEL-S-49 MAL FBP1 HEL-S-32 ENO1 PCK1 HEL-S-26 PMC7082774__F1 Emerging roles for branched chain amino acid metabolism in cancer ACLY PPM1K MTOR PMC8137995__F4 Modeling the Th17 and Tregs Paradigm: Implications for Cancer Immunotherapy FAU ITK FOXP3 MTOR IL23R PMC8160296__F5 Circular RNAs in Hepatocellular Carcinoma: Emerging Functions to Clinical Significances BAX BAD PTEN PMC9343399__F7 Key role of aminoacylase-1 in myocardial fibrosis and the regulatory effect of 20(S)-ginsenoside Rg3 in heart failure TGFBI PMC12231332__F3 Relationships between pro-inflammatory cytokines and bone signaling pathways affecting osteoblastogenesis and osteoclastogenesis CRP SOST IGF1 SMAD4 NFATC1 MMP9 TRAF6 RUNX2 IL1B CTNNB1 PMC8592284__F4 Functional Amino Acids and Autophagy: Diverse Signal Transduction and Application ACLY MSRA GLS FOXO3A EP300 ATF4 SLC7A5 MAPK8 PMC7527140__F2 Deduced sterol biosynthesis pathways in Symbiodiniaceae IPP EBP DHCR7 PMC4012865__F9 Activation of DCs by HKBA showing the stimulation of TLR2 and TLR9 and cross-talk between their respective signal transduction pathways TLR9 TNF MYD88 PMC4388554__F11 Role of Notch Signalling in CD34+ Chronic Myeloid Leukaemia Cells: Cross-Talk between Notch and BCR-ABL BCR GSK3B PTEN MTOR HES1 CTNNB1 PMC4262066__F3 Schematic presentation of mechanisms leading to cell cycle deregulation in growth plate dtd chondrocytes CDK6 CDK4 CTNNB1 PMC8468939__F8 Mechanistic Insights of Anti-Immune Evasion by Nobiletin through Regulating miR-197/STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer (NSCLC) Cells STAT3 EGF EGFR PMC7001001__F4 Bioinformatics Analysis of miR-124-3p and Its Downstream Targeted Genes(A) The genetic interaction network of miR-124-3p built by Biovista Vizit RYR2 FZD5 SHC1 ANXA4 SGMS1 CTNND1 FLOT2 FURIN FMR1 ITGB1 ROCK1 RELA GRB2 PMC5582996__F1 Configuring a robust nervous system with Fat cadherins FAT4 VASP HOMER1 APP ATN1 FAT2 DCHS1 FAT3 PMC3693462__F1 BRCA1: A Missing Link in the Fanconi Anemia/BRCA Pathway RAD51C BRCA1 USP1 BRCA2 PALB2 PMC7847682__F1 External and intrinsic mechanisms to mediate immunotherapy resistance for CSCs in HCC APC CCL20 CD47 CTNNB1 PMC6618483__F8 Model describing Etv4 and Etv5 induction following distal NGF stimulation ETV5 NGF ETV4 PMC3591264__F7 Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression RPL27A RPL35 RPL31 RPL12 RPS5 RPS4X RPS2 RPSA RPS27A RPL38 HEL-S-310 RPL13 RPL37 RPL3 RPS29 RPL39 RPS10 RPS24 RPL36A RPL29 NOP56 PMC4409526__F4 Diagram depicting molecules involved in actin cytoskeletal regulation mediated by NMDA signaling pathways and having altered mRNA expression in bipolar disorder CDC42 CDC42BPA PPP1CC KALRN ACTN2 ARHA RAC1 OPHN1 HEL32 DBN1 ROCK1 PRKCA PPP1R9B ARHGEF7 PFN2 PPP1R9A HEL-S-15 PMC3591264__F6 Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression HEL-S-66p UBB PMC4409526__F3 Diagram depicting altered mRNA expression of molecules involved in the regulation of the actin cytoskeleton by NMDA signaling pathways in schizophrenia CDC42 LIMK1 PPP1CC MARCKS KALRN ACTN2 OPHN1 PARD3 HEL32 DBN1 ROCK1 PRKCA PPP1R9B PPP1R9A HEL-S-15 PMC7392137__F1 The original model for Wg signaling in Drosophila, the core of the current model for the canonical Wnt signal transduction (the Wnt/Beta-Catenin pathway) APC GSK3B ELL LRP5 LRP6 CTNNB1 PMC7392137__F2 Two well-known non-canonical Wnt signalling pathways, including Wnt/Ca2+ (right) and Wnt/PCP (left) ROR1 JUN ROR2 RYK ARHA RAC1 DAAM1 PMC3386597__F4 AhR-related signaling molecules are enriched within the AML Signalisome DNMT3B CBX2 ADAM19 PLK2 PHC2 ATP1B1 ENTPD1 RORA CDK6 MAF MMP2 AHR ATL1 KAT2B PMC3386597__F3 AML Signalisome GFER OSM PHC2 SLC37A3 RPLP2 RORA MGA COLEC12 CASQ2 MAF ASPH MXD3 AHR MMP2 HEL-S-108 ATL1 HTT LUZP1 ZNF618 TRPM7 RNF141 CBX2 BACH2 ADAM19 ELP2 MYH10 RAB34 NKX2-3 SPOCK1 HUNK MED1 NFIA PALM HNRNPA2B1 GNE FAU FRAT2 PIR RPS25 SNTB2 CENPA ZNF263 KAT2B PMC3819341__F1 Summary of therapeutic invention points in the myostatin signaling pathway FSTL3 ALK SMAD2 SMAD4 MTOR PMC5808457__F1 Tumor Suppressor Candidate 2 (TUSC2; FUS-1) and Human Cancers TUSC2 EGFR MDM2 PMC4905210__F1 Targeting the mevalonate pathway using statins and its feedback loop using dipyridamole induces tumor cell apoptosis HMGCS1 HMGCR LDLR PMC4428041__F3 Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease USP28 ITCH USP12 ATOH1 PMC2639036__F1 Single-strand break repair pathways POR OGG1 PNKP FEN1 PCNA SSB PMC4168797__F7 Paraquat hijacks the PPP to induce oxidative stress and cell death HEL107 GLS OGDH HEL-S-68p HEL-S-162eP PMC4515436__F12 Short range signalling between germline stem cell and its niche CSF1 GDNF GSC RET PMC6874879__F2 LKB1 loss alters cancer cell biology TSC2 FAS KEAP1 MFN1 ULK1 MTOR MFF PMC6874879__F1 LKB1-proficient tumors display coordinated control of metabolism, DNA repair, and mitochondrial dynamics STRADA TSC2 MTOR MFF PMC7177879__F2 Regulatory network controlling SE induction in which the auxin-related epigenetic processes play a central role TPR ARF6 ARF3 ARF5 PMC5835590__F9 Summary of the main differences between NE high and low subtypes of SCLC REST NEUROD1 ASCL1 NKX2-1 MYC ASCL2 DLL3 YAP1 PMC8614792__F4 MicroRNA Sequencing Analysis in Obstructive Sleep Apnea and Depression: Anti-Oxidant and MAOA-Inhibiting Effects of miR-15b-5p and miR-92b-3p through Targeting PTGS1-NFKB-SP1 Signaling ATR CD2 CHIC2 CDK2 ATM PTEN HEL-S-11 GATA4 CDK4 PMC10223772__F5 Proteins related to resistance in HIGS lines infected with A. flavus TF MYB ERF CERKL LOX PMC5367635__F1 Metabolic reprogramming in T cell fate and function TG FAS IL7R MTOR PMC7488620__F7 Parental RHC reverses ischemia-induced changes in rod phototransduction pathway proteins GUCY2D RCVRN GUCA1B GNB3 GNAT1 GUCY1B1 GUCY2F GNB5 GNAT2 PDE6D PDE6C CNGA1 RHO GNGT2 ARR3 GNB1 SAG PDC OPN1SW PMC10390225__F2 Mononuclear phagocyte system in IgA nephropathy: pathogenesis and prognosis FCAR HEL-S-62p CD14 IL6 MIF PMC7373735__F1 General mechanism of ferroptosis associated with lipid, amino acid, and iron metabolism LOX STEAP3 GPX4 LPCAT3 CP ADA PMC8662361__F6 Aging Affects KV7 Channels and Perivascular Adipose Tissue-Mediated Vascular Tone MAX HEL60 UBC ACO2 PIK3R2 FASN PLIN5 NR1C2 FADS2 ACACA CS RXRG SDHB SUCLG1 FABP5 RXRA HEL-S-32 ADFP MDH2 SDHC PMC4987476__F8 Graphical summary of anti-inflammatory activity of bee venom in LPS-activated BV2 glial cells TLR4 IRAK1 TRAF6 MYD88 PMC8395232__F1 Mitochondria-Induced Immune Response as a Trigger for Neurodegeneration: A Pathogen from Within TBK1 CGAS STAT2 IL16 IRF9 TLR9 AIM2 IRF3 PMC3468610__F4 Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing TP73 PPARG TNFRSF10C HGF PIK3CD AKT3 PIK3R1 SMAD4 PTEN CDKN2B MYC FGFR2 PLAT RALA PDPK1 CHUK RALBP1 BAX JUN FRS2 HGFAC PLG hEMMPRIN KRAS FOS TIAM1 RELA RXRA PEMT CASP3 NFKBIA MAP2K2 GRB2 TNFSF10 REL FADD PMC8220211__F6 JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment STAT4 PMC3262999__F1 Interaction between Jak2/Stat5 signaling and the PI3K/Akt1 pathway in mammary epithelial cells PRLR PRL PTEN SRC PMC8220211__F3 JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment STAT4 PMC7393602__F1 Nav1.5 promotes the activity of NHE-1, resulting in the acidification of the peri-membrane, which favors the proteolytic activity of Cat and MMPs (yellow line) CD44 SNAI1 RAC1 PMC6721482__F2 The regulation of Keratin 6, 16 and 17 during skin wounding and in psoriasis IFNG STAT3 STAT1 IF2B1 TLR3 EGFR MTOR TNF PMC2878914__F1 Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway NR1i1 EBP CTNNB1 PMC3340364__F6 Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells CASP9 ATR CASP3 PMC6704427__F1 Genetic abnormalities in HNSCC contribute to poor tumor immunogenicity PIK3CA SOX2 MTOR PMC5661397__F6 Pentose phosphate pathway (dotted lines) and associated metabolic pathways (solid lines) HEL107 SORD PMC5866017__F6 Enriched pathways in cholangiocarcinoma RAF1 GRN POR PNKP FYN RBBP4 CCNE1 E2F3 RAE1 GBP2 FAT10 CASP9 PTN EGR1 GNB2 KHSRP EZH2 CXCL10 RAC1 FOS NR3C1 CAND1 PARP1 HDAC1 MCM7 NONO NEDD4 PRKDC HEL-S-162eP MCM3 ARHGEF1 MCM2 TRAF2 PMC7141137__F3 Intracellular regulators that link morphogen signaling pathways during DV and AP patterning of the ectoderm in vertebrate embryos FOXB1 SIX3 CLK2 CTNNB1 PMC8601834__F2 Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases RIPK3 BAX FAS TRADD TNF APAF1 FADD PMC2713381__F8 MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway RAF1 GRB2 PDK2 PMC6831629__F8 Hypothetical model to depict the role of Trpc1 channels in linking the inhibition of BMP pathway by noggin, and the activation of Cav1.2 channels in ectodermal cells SOX2 TRPC1 ZIC3 PMC6597298__F7 Schematic diagram showing the critical role of FDPS in normal prostate and prostate cancer and its associated potential mecahnism (s) STAT1 PTEN FDPS PMC7330943__F8 Estrogen signalling pathway (a) is solid active instead, prolactin pathway (b) results are not in the group of the strongest expression level PRLR TH RAF1 MAPK13 SOS1 KRT28 KRT14 MCL1 KRT39 SOCS2 ATF2 KRAS FOS HRAS SOS2 HSPA2 CHUK MMP2 NRAS KRT27 PMC5519011__F3 redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models PIG59 MALL ME2 MAL HEL-S-11 CS ME1 TNLG7C CIT PMC4408933__F3 Adipocytokine signaling pathway as represented in the Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/kegg1.html) (; , ) STAT3 NR1C1 TRADD LEPR NPY SOCS3 AgRP MTOR TRAF2 PMC2564730__F3 Use of MIMO models to infer regulatory interactions in breast cancer cells EGF EGFR IGF1R MTOR PMC9006445__F3 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies SLC3A2 ATR CDO1 TRADD GPX4 MLKL SLC7A11 MTOR RIPK3 CDK2 RIPK1 AQP1 FADD PMC9006445__F2 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies ATG101 ULK1 AMBRA1 ATG14 PMC8632930__F1 Antitumor effect of PARP inhibitors CHD2 RAD51 BRCA1 BRCA2 ATM PALB2 SSB XRCC3 PMC6995234__F7 Expression of genes in central metabolic pathway in wild-type (WT) and engineered M RPE FH TK1 FBP2 OGDH HEL-S-162eP FBP1 PDC PMC9006445__F1 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies STAT3 BAX FAS TRADD TRAF2 FADD PMC4211430__F7 Indian Hedgehog Mediates Gastrin-Induced Proliferation in Stomach of Adult Mice CCKBR IHH SMO PMC4959089__F1 General schematic model of a NR signaling pathway GC PC HP PMC6948370__F11 Diagramatic representation of the possible molecular mechanism of CXXC4-mediated tamoxifen resistance CXXC4 CDK6 APC GSK3B LRP5 LRP6 CCND1 CDK4 CTNNB1 PMC9258696__F1 Osteoimmunology: The correlation between osteoclasts and the Th17/Treg balance in osteoporosis CTSK NFATC1 MMP9 PMC8523237__F1 Kidney Cell Pyroptosis in Chronic Kidney Disease and the Effects of Traditional Chinese Medicine NLRP1 NLRP3 AIM2 DMD PMC10305000__F6 Reconstructed fatty acid synthesis pathway of ST7-B DLAT GPD2 DLD PMC8787129__F11 Liver Fibrosis—From Mechanisms of Injury to Modulation of Disease RHO PMC4954849__F1 Interplay between VEGF and Notch signaling is important for tip and stalk cell differentiation in physiological angiogenesis DLL4 CTNNB1 PMC8946298__F3 Cross-Talk between p53 and Wnt Signaling in Cancer APC AXIN1 TCF4 CTNNB1 PMC3646015__F6 Developmental Gene Discovery in a Hemimetabolous Insect: De Novo Assembly and Annotation of a Transcriptome for the Cricket Gryllus bimaculatus SUFU SMO PMC9006445__F4 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies STAT3 BAX GSDMD TRADD NLRP3 PRKCQ EGFR CCR7 DFNA5 SRC FADD PMC5533789__F6 Hypothetical signalling network and status in bovine cumulus cells modified by FSH-priming based on RNA-seq expression signature TNFAIP6 PTX3 TGFB1 HAS2 IRF7 PMC7869011__F4 Retinoic acid (RA) synthesis and signaling activation during in vitro cardiac differentiation RARA RARB RBP1 LRAT RBP4 RDH10 RXRG PMC11545013__F10 Elevated RBP4 in Subclinical Ketosis Cows Inhibits Follicular Granulosa Cell Proliferation and Steroid Hormone Synthesis CDC2 BAX CYP27B1 CCNE2 STAR CYP17A1 RBP4 CCND1 PMC6593264__F2 Dual aspects of GM-CSF immunomodulatory effects CD40 TH CX3CR1 CD33 PMC7053436__F5 Central role for Ras-MAPK signaling in habituation learning ERCC2 LAMA1 COX10 POGZ AP1S1 BRAF PTEN DMPK GRIK2 SHANK3 MANBA CACNA1G NF1 WAC CASK ZEB2 NRXN1 AP1S2 PTPN11 CC2D2A KRAS ARX PACS1 HRAS RNASEH2A TSC1 ADK COG7 EHMT1 PMC3136877__F1 mTOR signaling cascade in the pathogenesis and prevention of skin cancer RHEB TSC2 TSC1 PTEN MDM2 PMC9418006__F7 Metabolic pathways encoded by Comchoano-1 and Comchoano-2 consolidated from Pathway Tools tmp_locus_29 DAP MB PMC7912095__F2 Loss of LKB1 drives the tumor immune escape CXCL12 EZH2 CCL5 KRAS PMC2926929__F1 The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin LPA FLJ10842 LPP PMC8321592__F1 Cancer Genomic Profiling in Colorectal Cancer: Current Challenges in Subtyping Colorectal Cancers Based on Somatic and Germline Variants PIK3CA RNF43 SOX9 APC AXIN1 BRAF PCBP1 POLE CTNNB1 PMC8461181__F3 GnIH in Biological Rhythms and Social Behaviors CTNNB1 PMC6957567__F1 Brief overview of DDR signalling TOPBP1 ATR ATRIP RAD51 MRE11A DNA2 BRCA1 H2AX BRCA2 ATM PALB2 BLM PMC5123406__F1 Conceptual model of viral integration BRD4 ATR RAD51 BPI ATM PMC6299275__F3 Canonical pathway analysis using MetaCore identified EGFR, PDGFR, and mTOR signalling as the top 3 canonical pathways modulated in FCD type II patients EGF PDPK1 TLR4 EGFR MAPKAPK2 AGTR1 TTI1 PTMS MTOR TRAF6 GHR DEPTOR PMC4872954__F1 Obesity versus osteoarthritis: beyond the mechanical overload STAT3 MAP3K7IP1 LEP TRADD JAK1 TRAF6 TRAF2 MYD88 PMC5833784__F2 Immunological consequences of kidney cell death RIPK3 MLKL RIPK1 PMC6856869__F4 Recognition of HSV-1 infection by pattern recognition receptors (PRRs) CGAS IFI16 IRF3 IRF7 PMC6765066__F7 HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases STAT3 HMGB1 TLR4 SMAD2 MAL CXCL8 FGF2 PMC8897942__F1 MUC1 is a potential target to overcome trastuzumab resistance in breast cancer therapy STAT3 MUC1 MTOR CTNNB1 PMC8888544__F5 Gamma-tocotrienol, a radiation countermeasure, reverses proteomic changes in serum following total-body gamma irradiation in mice BRD4 PPARG CSF1 OSM HEL-S-62p EGFR ALB MAP3K8 CDKN2A STAT1 CASP4 TLR4 AHR IL1B JUN CSF2 NR1H3 JUNB ORM1 IL6 HBEGF ITGAM CBL NFKB1 RELA NFKBIA HP GRB2 IL23A PMC3532456__F3 Interleukin (IL)-13 and IL-4 signaling pathway STAT3 IL13RA1 JAK3 JAK1 TYK2 IL13RA2 PMC3532456__F2 Transforming growth factor (TGF)B signaling pathway TGFBR2 PLG ARHA PMC8471880__F2 Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism STAT3 NLRP3 PMC6555274__F4 TGFB signalling pathway with FOXN3 BAMBI LTBP1 IFNG RBX1 SP1 FST SMAD4 SKP1 NODAL ARHA FOXN3 PITX2 PMC7642035__F6 Therapeutic Interaction of WNT Pathway Activation and Asparaginase APC CTNNB1 PMC4091806__F1 A New Lnc in Metastasis: Long Non-Coding RNA Mediates the Pro-metastatic Functions of TGFB STAT3 ZEB2 PMC7094958__F2 RIG-I-like receptors: their regulation and roles in RNA sensing TBK1 MAVS IRF3 IRF7 PMC6642071__F1 Methionine–homocysteine cycle and biosynthesis of betaine MSRA MSRB2 CHDH MSRB1 HEL-S-61p PMC5331612__F1 ChREBP regulates fructolytic gene expression KHK FASN PKLR PMC1183479__F8 Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2) TSC2 TSC1 MTOR EIF4E PMC7863575__F1 Steroidogenic pathway HSD3B2 CYP21A2 SRD5A2 STAR CYP17A1 CYP11A1 SULT2A1 PMC7348953__F1 Therapeutic Targeting of the Wnt Signaling Pathway PORCN TNKS APC GSK3B LRP5 LRP6 CTNNB1 PMC5267499__F1 Proteomics Analysis of Ovarian Cancer Cell Lines and Tissues Reveals Drug Resistance-associated Proteins POR TES BAD UNG MTOR SRA1 PMC7094958__F4 RIG-I-like receptors: their regulation and roles in RNA sensing NLRP12 TBK1 RNF125 MAVS TRIM25 DHX15 SFPQ OASL IRF3 IRF7 CYLD ZCCHC3 PMC5097370__F4 Regulation of myofibroblast formation by TGFB1 JUN SMAD2 SMAD4 PMC4435618__F2 Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans TSC2 TSC1 EIF4EBP1 FOXO3A BNIP3 GRB2 MTOR EIF4E PMC4435618__F1 Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans GSK3B GRB2 PMC7918075__F4 Putative model for the involvement of cell signaling pathways in the induction of survival by type I (A/B) and II (G) IFNS in CLL cells STAT3 JAK1 SRC TYK2 PMC4287622__F4 Protein Interactome of Muscle Invasive Bladder Cancer HRAS CDKN2A JUN THBS1 RAF1 CDKN1A EGFR COL3A1 CCND1 CDK4 PMC8021683__F1 Summary of signaling pathways regulating cardiomyocyte proliferation TF NRG1 LATS2 ERBB4 APC GSK3B ERBB2 CDKN1C CCND1 CTNNB1 PMC4287622__F3 Protein Interactome of Muscle Invasive Bladder Cancer GNAI3 TNC BAD FAS ITGB4 EGFR CTNND1 PRKCZ PTEN LAMC1 TGFBR1 CTNNB1 TGFBR2 MYLK PRKCA ITGA6 KDR MDM2 CDK4 MAPK1 BAX THBS1 JUN LAMC2 ERBB4 PDGFA PTGS2 VEGFA FGF2 ARAF ERBB3 HRAS CDKN1A COL4A6 CDKN1B CASP3 LAMB3 ERBB2 CDK2 BCL2 FGFR3 BDNF LAMA3 YWHAZ PMC4538335__F1 Lesser-Known Molecules in Ovarian Carcinogenesis ERBB2 MTOR SRC TNF PMC2955921__F2 Scheme summarizing the differential effect of PARP-1 inhibition versus silencing on SSB repair via the BER pathway SPR PCNA SSB PMC8008798__F1 General scheme illustrating the potential mechanistic pathway of Notch signaling in the pathogenesis of pulmonary fibrosis MAML1 MAML3 MAML2 RBPJ PMC8349779__F2 Reprogramming of TCA cycle, fatty acid and glutamine metabolism in renal cancer LPA ABAT FAS FH LOX GLS COX2 HEL-S-5 MYBBP1A MYC PMC8349779__F1 Reprogramming of glucose transport and glucose metabolism in renal cancer HEL107 STAT3 PC EZH2 PMC11663741__F10 Hypothesized immune mechanisms of fish spleen against N ZAP70 CD79B ACSL3 CXCL13 NFATC2 C1S C1R PIK3CD CD22 CLEC4E MYD88 FTH1 PRF1 FTL PLCG2 CP PMC6592250__F5 Coordinated interactions between glycolysis, citrate cleavage enzyme, and glutaminolysis for the fatty acids biosynthesis in growing tumor cells FAS HEL-S-26 NNT PMC6283168__F3 Triacylglycerol (TAG) lipolysis in Drosophila: biochemistry and main regulatory pathways SIK3 PLIN1 ADFP PMC7215558__F2 Autophagy and UPS alterations bridging altered proteostasis with neuroinflammation, the paradigm of protein glycation MTOR PMC3439854__F2 Transcriptional regulation of PDPN expression PDPN STAT3 STAT1 JUN SMAD2 SMAD4 PTEN FOS IL1B PMC6283168__F2 Triacylglycerol (TAG) synthesis in Drosophila: biochemistry and main regulatory pathways LPA GPAT4 DGAT2 AGPAT3 FASN PCYT2 PMC12114829__F1 Biosynthesis of BRs in plants PTS H1-6 MPO CP PMC4580081__F2 Interactions of chaperone proteins with Stat3 panel (A) and Jak2 panel (B) STAR CDC37 JAK1 PMC6903413__F5 NFKB activation in inflammatory cells TRADD NLRP3 IL16 IL18 IL6 VCAM1 TRAF2 MYD88 PMC6903413__F4 NFKB pathway in pancreatic acinar cells CCK IL6 TNF PMC4315934__F4 Cardiac muscle contraction and changes with exercise HGF IGF1 GATA4 PMC3430718__F7 SOCS1 regulates the IFN but not NFKB pathway in TLR-stimulated human monocytes and macrophages SOCS1 TLR4 MAL IRF1 IRF3 PMC3870464__F2 Protein components of the pheromone response network constructed by the PCST approach TF CDC20 ARAP1 CCR4 INS ACE2 PMC1133850__F10 Vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication EGR1 ATF1 PMC5114008__F2 Adaptive Stress Responses During Tumor Metastasis and Dormancy ATF4 EIF2A UNK PMC8276772__F1 Centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation OLFM4 BCOR OSM EPO PTEN RHO MTOR BMI1 CTCF NCOR1 PRC1 NPM1 SRC HOPX CCL11 TET1 POLI NPM2 ASCL2 NCOA1 NCOR2 BRCA1 PAK1 HP GRB2 BCL6 PMC7181577__F7 Proposed effect of NgR reduction on APP traffic to lysosome through Rho/ROCK2 pathway LINGO1 ARHA PMC8945922__F7 Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components ATG10 BAX ATG3 ATG12 MCU IGF2 PMC4540028__F3 Comprehensive analyses of genomes, transcriptomes and metabolites of neem tree DDT IPP MVK ADA PMC8945922__F5 Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components RHEB TSC2 ATG3 ATG14 PTEN ATF4 TIGAR MTOR EIF2A PMC9652280__F4 Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic syndrome MOK LAT PMC9663771__F2 Angiopoietins in Neovascular Diabetes-Related Retinal Diseases ARHA RAC1 PMC8663872__F7 To explore the Radix Paeoniae Rubra-Flos Carthami herb pair's potential mechanism in the treatment of ischemic stroke by network pharmacology and molecular docking technology MAX CDC42 TH MAFK BAD GAL LTA STAR RAF1 TIRAP ITCH LAT MAK CD19 MYC MGA FADD PMC3428775__F3 Model depicting effects of Wnt-stabilized Beta-catenin through Tcf proteins in mESCs TCF3 SOX2 PMC10468808__F2 Activation of NFKB and MAPK signaling pathways regulates the expression of catabolic factors TRAF6 TNF TRAF2 PMC2727709__F1 Multiple previously established signaling cascades in activated mast cells with quantitative proteomic data from MCP5 cells represented as heatmap bars beside individual proteins SYK BTK FYN IL3 PC LYN GRB2 SRC GAB2 TYK2 PMC7855580__F2 Systemic inflammatory response from SARS-Cov-2 may trigger atherosclerosis NLRP3 HEL-S-62p TNF PMC2795398__F1 Endotoxin binds to CD14 and Toll-like receptor 4 (TLR4) on the surface of monocytes and endothelial cells COX2 TLR4 CD14 TNF MYD88 PMC4110479__F3 Tolerogenic properties of plasmacytoid dendritic cells (pDCs) CD40 STAT3 ICOS CD80 CCL22 TSLP TLR9 AHR TLR7 FOXP3 JAK1 SRC PMC4110479__F2 Proinflammatory properties of plasmacytoid dendritic cells (pDCs) STAT3 TBK1 TLR9 IRF3 IRF7 TLR3 TLR4 NOD2 TLR8 NOD1 TLR7 JAK1 SRC TYK2 IL1B PMC4428674__F1 Mediators released from activated MCs LTB HEL-S-62p KIT KITLG IL1B PMC5814196__F1 Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer BAMBI SOST INVS SIAH1 APC NOTUM CER1 SMAD4 LRP6 SKP1 ARHA NLK PMC7533603__F4 Modeling the metabolic modifiers of T-cell function in Tconv and Treg, showing differential impacts of glycolysis and oxidative phosphorylation on each and the role of the mTOR pathway in mediating this RPTOR FOXP3 PMC4295541__F2 Generation of ceramide and FTY720-P CERS3 CERS5 CERS1 tmp_locus_29 CERS2 CERS6 PMC8476624__F6 Investigation of proteins important for microcirculation using in vivo microdialysis after glucose provocation: a proteomic study BTD HEL111 AFM ORM2 ALB AHSG REN AFP APOH F2 F10 F9 HBB KNG1 APOC3 SERPINC1 HMFT1766 A1BG SERPING1 AMBP ORM1 RBP4 PGLYRP2 C1RL HBA2 APOA2 APOB HP BDKRB2 CP PMC8476624__F5 Investigation of proteins important for microcirculation using in vivo microdialysis after glucose provocation: a proteomic study TF CENPF HMFT1766 A1BG BTD AMBP HEL111 ORM1 SERPINA1 RBP4 PGLYRP2 AFM C1RL HBA2 ORM2 APOA2 ALB AHSG APOH HP HBB KNG1 CP PMC5908130__F5 Perturbed gene network in placenta that may be reflected by the changes of circulating miRNAs in PTL TNC VASP TJP1 PTEN MTOR MYC TNR KRAS HEL114 FYN PRKCA KDR SRC PMC2894843__F3 Ingenuity Pathway Assist (IPA) analysis of significant genes involved in cell death NLRC4 STAT3 PTPRO CSF2RB CTSL CASP3 IL18 ATM DCN FGF2 MYD88 PMC7324605__F5 Polyamine pathway in patients with Diffuse Cutaneous Leishmaniasis SMS SRM PMC8024183__F7 The differentially expressed genes mapped in p53 signalling pathway, which are upregulated after radiation exposure (highlighted in red) ATR AMT ATM ADA PMC8541835__F1 RNases H1 and H2: guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis PMC6146604__F1 Lignin biosynthesis HEL107 RPE CAD HEL-S-62p CS PMC2746245__F2 Toll-like receptor (TLR) pathway TLR3 TLR4 TLR8 TLR5 TLR7 TRAF6 IL1B MYD88 PMC7744622__F4 Roles of p53 and PTEN signaling pathways in the regulation of autophagy ATG101 RHEB MLST8 TSC2 TSC1 MAP1B ULK1 AMBRA1 ATG14 PTEN TIGAR MTOR PMC7744622__F3 Major signaling pathways involved in the regulation of autophagy AAMP ULK1 ATG14 PTEN MTOR ATG101 RHEB MLST8 TSC2 RICTOR TSC1 PI3 AMBRA1 PMC8613976__F1 NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity GSDMD NLRP3 MYD88 PMC2746245__F6 Injury-induced changes in the nociceptive pathway CXCR3 IL16 CCR5 CCR2 TRPV1 CXCR4 PMC10519534__F8 DZP active constituents on myopia through the “AGE-RAGE diabetic complication signaling” pathway TF STAT3 BAX SELE SMAD4 MMP2 CDK4 PMC7867275__F1 Heme synthesis pathway and mechanism of 5-aminolevulinic acid (5-ALA) fluorescence CPOX EGFR ABCG2 PMC11171322__F8 Graphical overview of representative exclusively differentially expressed genes from our RNA sequencing data in the myeloid and lymphoid group that are clearly assigned to the BMP/TGFB signaling pathway TGFB1 TNFRSF19 FZD9 IRAK1 IBSP TNF TGFBR3L GSK3A IRAK3 COL4A2 COL8A2 COL9A2 TNFRSF11B MSX2 FADD PMC5790522__F7 Transcriptome profiling identified differentially expressed genes and pathways associated with tamoxifen resistance in human breast cancer RAF1 PIK3R2 PIK3R1 ATF2 ELOVL4 GNAS ADCY8 ATP6V1C2 PI3 HSPA2 GFRA3 MMP2 SRC CNTN5 CREB1 CALML3 SP1 HRAS HBEGF ADCY3 PRKACG SOS2 CRISP3 PLCB1 CALM1 PLCB2 CST4 ADCY1 GRB2 SOX8 CREB3L3 HEL-S-103 GNAI3 ART3 GNAO1 CALML6 CREB3 CREB5 KCNJ5 NPY1R PIK3R3 EGFR AKT3 GABBR2 CALML4 SHC2 GABBR1 CREB3L2 KCNJ3 SHC4 ARNT2 ADCY9 SIX3 NR3A2 MTMR11 ATF4 PLCB3 ADCY6 SHC3 GABRP HSP90AB1 GNAI1 JUN GNG4 KCNJ6 OPRM1 MMP9 PTPRN2 KRAS DHRS13 PRSS27 FKBP5 ABCA13 FKBP4 ATF6B C2CD4D LYPD5 MAGEC1 HEL-S-125m KCNJ9 PRSS33 MUC2 MGAM MAP2K1 MAP2K2 GRB14 PMC7363309__F1 Utilizing cooled liquid chromatography and chemical derivatization to separate and quantify C3-epimers of 25-hydroxy vitamin D and low abundant 1A,25(OH)2D3: application in a pediatric population CYP27B1 CYP24A1 CYP27A1 PMC5382784__F1 Schematic illustration of extracellular oligopeptide metabolism in P DPP7 DPP4 PTPA PMC8524104__F1 Lactate in the tumour microenvironment: From immune modulation to therapy HEL-S-133P HEL-S-162eP LDHB MTOR PMC3446895__F5 Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells BTG3 GADD45A PMC7916160__F2 Overview of phosphatidylinositol-3-kinase (PI3K)/AKT/mTOR signaling pathway and inhibitors RHEB PTEN IRS1 EIF4E PMC10915960__F1 Preconditioned mesenchymal stem cells with high therapeutic potential in various pathologies MSC PMC11841260__F3 Application of spatial transcriptomics to rheumatoid arthritis S100A8 MMP3 CD200 IL6 FAP PMC9681882__F3 Plasma proteomic profiling in postural orthostatic tachycardia syndrome (POTS) reveals new disease pathways COMP APOD THBS4 CNDP1 PMC7059589__F2 Neuronal roles of atypical protein kinases (aPKCs).(a) aPKCs mediates nerve growth factor (NGF) response NGF GULP1 GSK3B LRP5 LRP6 MTOR IRS1 HEL-S-44 PMC8535591__F2 Insulin-like Growth Factor 1 Signaling in Mammalian Hearing BAD ULK1 GSK3B IGF1R ATG101 RHEB TSC2 FOXM1 TSC1 IGF1 CDK2 GRB2 CCND1 PMC6113426__F3 Summary of apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like (APOBEC)3B transcriptional regulations in cancer cells ATR E2F4 RELB PC ATM TNF LIN9 PMC7164249__F1 Merlin regulates different developmental signaling pathways CDC42 ERBIN EGFR APC RAC1 CTNNB1 PMC2814006__F1 IL-1 and TNF signal transduction events MAP3K7IP1 TRADD TAB3 IRAK1 TRAF6 TNF TRAF2 MYD88 PMC4626744__F2 Enzymes involved in PGE2 synthesis and metabolism HPGD PTGES3 PTGS1 AKR1C2 PLA2G5 PTGES AKR1C1 PTGS2 PLA2G2A PMC4626744__F4 PGE2 synthesis, action, transport and metabolism in granulosa cells HPGD PTGES PTGS2 SLCO2A1 PMC9611771__F3 Identification of differentially expressed genes in mouse paraspinal muscle in response to microgravity TH GAL BAD tmp_locus_29 LAT PLEC APP PMC4872542__F9 Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro CASP9 FAS CASP8 GSK3B CASP3 PMC2882184__F1 Pathway analysis using all altered genes and proteins MSH6 EGFR HEL-S-28 IRF1 ITGB3 CTNNB1 BMI1 RPS16 STAT1 RBBP4 HOXA10 HBB RPL26 PMC3119709__F1 Macrophages as a Battleground for Toxoplasma Pathogenesis STAT3 CSF2 SOCS2 ARG1 IL6 IL23A PMC4383688__F1 Molecular Pathways: Aspirin and Wnt Signaling—A Molecularly Targeted Approach to Cancer Prevention and Treatment TCF7L2 APC LRP5 LRP6 MYC CTNNB1 PMC8111291__F8 FOXC1 Negatively Regulates DKK1 Expression to Promote Gastric Cancer Cell Proliferation Through Activation of Wnt Signaling Pathway APC LRP5 LRP6 CTNNB1 PMC8027476__F6 Schematic diatgram of CAFs induced renal cancer progression STAT3 AIP AHR SRC PMC5109916__F1 Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3 GSK3B PTEN PMC4060523__F2 Signaling pathways that positively regulate ecdysteroidogenesis in the PG in Drosophila melanogaster TSC2 TSC1 SMAD2 PMC12239316__F6 Genetic model for evolution from all-black to all-white yak DCT KIT TYRP1 MAP2K1 MAP2K2 KRAS PMC8834284__F1 Characterization of Gfat1 (zeppelin) and Gfat2, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in Drosophila melanogaster OGT PGM3 PMC4461826__F1 Mammalian cells employ two principal DNA double-strand break (DSB) repair pathways ATR RAD51 BRCA1 ATM PALB2 BLM PMC6019448__F7 Avian and mammalian OASL involvement in RNase L and RIG-I signaling CARD14 MAVS OASL RNASEL PMC3435458__F7 RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells TRADD RGS10 TNF FADD PMC3258432__F6 Factors shown to promote or inhibit the vascular normalization phenotype in tumors PDGFD PIGF EGFR RHOB RGS5 PDGFC NRP1 MTOR VEGFA PMC7578900__F7 Signal pathway of PIO on mitochondria‐mediated apoptosis in cisplatin nephrotoxicity BAX SIRT1 PMC4564205__F3 Complete Genome Sequence of a High Lipid-Producing Strain of Mucor circinelloides WJ11 and Comparative Genome Analysis with a Low Lipid-Producing Strain CBS 277.49 GGPS1 HEL107 FAS FH MAL GLA ACD CS ACOT11 MVK RPE IPP HMGCR RPIA HEL-S-162eP PDC PMVK PC MVD IDI1 CIT PMC2808176__F1 Example of pathway segments corresponding to FALZ identified from breast cancer data (Figure drawn with Cytoscape) TES JUP XPA MYB TSNAX YBX1 TAF9 XBP1 CCNH IRS1 ERBB3 PLAT EVL PIG59 IKBKB FBP1 MUC1 BCL2 IL6ST PMC2722219__F1 The TSC/mTOR signaling pathway RHEB TSC2 TSC1 NF1 PTEN MTOR IRS1 PMC6700727__F5 In vivo induction of demyelination by direct Mycobacterium leprae injection into sciatic nerves ERBB2 LCK PMC8750547__F1 Long Noncoding RNAs Regulate the Inflammatory Responses of Macrophages CIC TLR4 TRAF6 MYD88 PMC9367915__F2 Interplay of Developmental Hippo–Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer NEK1 ATR LATS2 SPOP TLK1 ATM PTEN ERG NOTCH1 PMC8308723__F1 Signaling Pathway and Transcriptional Regulation in Osteoblasts during Bone Healing: Direct Involvement of Hydroxyapatite as a Biomaterial SMAD1 DKFZp781O1323 SMAD4 RUNX2 CTNNB1 PMC4652152__F8 Comparison of gene networks affected by ozone exposure in males and females CD40 NOS2 LTA CSF1 CAD CXCL5 CXCL1 CD14 TLR5 CD40LG PTGS2 CXCL10 CCL2 FOS CXCL3 LTB IFNG IL18 CCL4 PMC4652152__F7 Ingenuity Pathway Analysis for inflammatory gene expression in females vs IFNG TLR1 LY96 TLR3 TLR4 TLR9 CD14 PMC9367915__F1 Interplay of Developmental Hippo–Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer CDC2 TOPBP1 ATR ATRIP BRCA2 STK4 PTEN ERG MYC LATS1 LATS2 BRCA1 WEE1 ATM PMC2826600__F4 Insulin and IGF1 signaling pathway to promote glucose uptake by GluT3 in neurons (shown) or GlutT4 in muscle (not shown) IGF1 KEAP1 PLTP MTOR PMC11121248__F7 Two separate mechanisms for the role of MerTK and ENG in TNBC progression ENG MYC MERTK PMC5937133__F1 Type 1 diabetes pathogenesis and B cell protective factors IFNG APC TNF PMC6163247__F2 Endoplasmic reticulum (ER) and mitochondria interactions BAX BAD CERS1 AIP BCL2 MCU CERS6 PMC6163247__F1 Metabolic implications associated to ceramide synthesis CD36 tmp_locus_29 PMC7591521__F6 CsIVa-mediated inhibition of miR-155/GSK-3Beta-NFKB signaling pathway TLR4 GSK3B CD14 IL1B PMC9343252__F7 MiR-146a targets CD147 in ALK+ ALCL promoting increased energy metabolism STAT3 ALK CEBPB PMC9294232__F1 Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma CDH2 BAX EGF PRMT6 PCNA HEL-S-62p EGFR SMAD2 SMAD4 TRAF6 COX2 CDK2 ATM ABCB1 PMC3805541__F3 MicroRNA Profiling in Prostate Cancer - The Diagnostic Potential of Urinary miR-205 and miR-214 HOXB5 TIMP3 POU4F2 SELE DDIT4 BNIP3 KIT EZH2 MTOR VEGFA MED1 XBP1 FOS ACSL1 INHBA PRKCE IL24 NFAT5 BMF TNFSF10 MAP2K3 NR3B3 PMC5482989__F7 Proposed mechanisms for crosstalk between AR and GDNF signaling and inhibition of prostate development by RET-mediated GDNF signaling GDNF RET PMC7843612__F6 TGFB pathway regulation by miR-331 CCND2 SMAD2 SMAD4 CCND1 PMC6952807__F1 TNFR1-mediated survival and cell death pathways RIPK3 MAP3K7IP1 CASP8 TRADD MLKL RIPK1 CYLD TRAF2 FADD PMC6105893__F10 Role of cFP as a virulence factor while in the host and also as a signal to induce expression of genes to protect the pathogen ROS1 CFP SET PMC4543283__F1 New pathway for memory B-cell activation in systemic lupus erythematosus (SLE) ICOS BCR PDC PMC7504726__F2 Antioxidant effect of quercetin on enzyme activity, signal transduction pathways and reactive oxygen species (ROS) BAX EGR1 MAF PMC7367293__F4 Ingenuity pathway analysis (IPA) of actin cytoskeleton signaling in the Xenopus laevis whole brain after exposure to the predatory salamander larva, Hynobius lichenatus ABI2 HEL114 CRK EGF TRIO PXN APC GNG12 APP SRC BAIAP2 FLNA PMC7367293__F6 CREB signaling in the Xenopus laevis whole brain after exposure to 24 h of a predation threat from the larval salamander, Hynobius lichenatus GRB2 TBP PMC3011108__F1 Schematic showing that when a cell membrane is injured the arachidonic acid pathway is activated to initiate the local inflammatory response through the production of prostaglandins, thromboxanes, and leukotrienes LOX COX1 PMC5940296__F1 Latest advances in the interplay of physical and biochemical signaling pathways leading to transcription in the tumor microenvironment GSK3B G3BP2 VTN PTEN VCAM1 MYC AXIN2 RET CTNNB1 PMC9096795__F5 Hereditary Systemic Autoinflammatory Diseases: Therapeutic Stratification ADA2 JAK1 PMC11591163__F3 Mechanistic diagram of the Nrf-2/AREs signaling pathway HEL-S-128m KEAP1 NQO1 AKR1B1 PMC11591163__F1 Blood–brain barrier is severely damaged during ischemic stroke IPP STEAP3 GPX4 SQLE SLC7A11 PSTK PMC6357531__F3 Proposed model by which polyphenols may modulate oxidative stress-induced pathways including Ang II, VEGF and TNFA MMP2 MMP9 MTOR NOX4 SIRT1 PMC4920993__F2 Predicted FA and TAG biosynthetic pathways in perilla seeds LPA DGAT1 DGAT2 PC CP PMC6397698__F4 Mechanism of action for combined TGFB and PD-1 pathway inhibition TGFBR2 IFNG IFNGR2 IFNGR1 TGFBR1 PMC8349779__F5 Altered metabolic events in renal cell carcinoma (RCC) LPA GC VHL PMC6321920__F1 HPV induces, yet tolerates, replication stress (RS) to promote viral replication through the ATR-dependent RS response KDM6B PCNA RRM2 CDK2 PMC108819__F8 Signalling pathways for EGF activation of c-jun EGF ATF1 GRB2 MEF2D PMC12029499__F1 Vitamin D synthesis and activation pathway VIT CYP2R1 CYP27B1 CYP24A1 PMC11694028__F3 Interaction of FBXW7 with signaling pathways and key molecules in gastrointestinal cancers CDC2 BAX EGF EGFR MAP4 ANXA2 APC PTEN MTOR CTNNB1 FBXW7 SHOC2 CDK2 NOTCH1 PMC3614663__F1 Diagram showing the crosstalk between the DNA damage response pathway and BMP-controlled osterix expression and osteoblast differentiation SMAD1 SMAD4 ATM MDM2 PMC6590643__F4 Simplified figure depicting the roles of RORC consensus pathway members, adapted from Yu et al SOCS1 IL17F STAT3 TH BATF TGFB1 IRF4 IL-21 RARA RORC FOXP3 BCL6 IL23A PMC2567351__F2 MAPK Signaling Pathway MAX LAT DAO PMC2567351__F1 T Cell Receiptor Signaling Pathway LAT GRB2 NPAT LCK CDK4 PMC4684475__F2 Inflammatory targets of therapy in sickle cell disease TRADD TNF MYD88 PMC4238899__F1 Organisation and lineage control in the intestine NEUROD1 ATOH1 ASCL2 PMC9498478__F5 Stress Response Mechanisms of Salmonella Enteritidis to Sodium Hypochlorite at the Proteomic Level GATC FIGN PTS ARG1 PMC7582682__F1 On the hematopoietic cell surface, transient receptor potential cation channel subfamily M member 7 (TRPM7) and magnesium transporter 1(MagT1) facilitate magnesium influx into the cell TRPM7 MAGT1 PCNA MTOR RUNX2 CCND1 IL1B PMC4808760__F6 Kinetic models describing the in vivo metabolism of the HDL apolipoproteins on each HDL size fraction APOA2 RPE APOC3 APOA4 APC APOE PMC5745449__F1 Modular Schema of the Stress Response Network ATP8 PDC PTEN HIF1A MTOR PMC12009910__F9 Notch signaling pathway: curcumin can bind Notch-1 protein and the bHLH domain of Hes1 HEY2 HES6 HES7 HES1 HES5 PMC12009910__F8 Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway APC NKD2 LRP5 LRP6 CTNNB1 PMC6791470__F1 T Helper 9 Cells: A New Player in Immune-Related Diseases BATF FOXO1 SMAD2 SMAD4 EZH2 IRF4 FOXP3 GATA3 PMC12009910__F3 Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway MAP3K7IP1 TAB3 PMC3773342__F5 Genes expressed higher in mutant mice revealed networks of interacting genes ZFP36 ASB1 JUN EGR1 CXCL13 HLA-DQA1 ADD2 ENPEP MAST2 HLA-DMA CD74 MAFF EGR2 RET PMC12009910__F2 Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway KEAP1 NQO1 PMC11130833__F1 Molecular activity of BTK- and BCL2- inhibitors in CLL BAX SYK BTK BCR PLCG2 BLNK BCL2 LYN MTOR PMC6475113__F5 EZH2 and Foxm1 as likely upstream regulators of PRLR-dependent gene expression PRLR SUZ12 OXTR BANP GADD45G ELL MAPKAPK3 KIF20A SSR1 PLK4 CCNA2 TBXT MYC NCOA7 PLK1 PAX7 JAM2 E2F4 CLPTM1L SPIB SMC2 HOXD9 CALML3 SAA1 FAT10 CENPF PIM2 GATA1 ATOH1 SERPINA1 KLK3 EZH2 TNF FLI1 CDKN1A BRCA1 HOXA9 LAMA4 NINL ASF1B HMMR PIP5K1C PTEN KHDRBS1 FOXM1 CDKN2C TOP2A BIRC3 DNMT3B CDC2 PLEKHG3 NGFR LRRC40 SELENON SFRP1 MKI67 CCNE2 PDGFRA NFYA DNAJB11 ENPP2 ZBTB16 KIF18A PMC5003019__F8 HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NFKB-YY1 pathway CX3CR1 CX3CL1 YY1 CR1 PMC3773342__F9 Proposed signaling process for GDNF-independent UB outgrowth GDNF BMP4 BMP2 NPY PMC5999746__F3 Reactive oxygen species (ROS) produce oxidative stress which in return converts the normal epithelium to early adenoma which leads to the next stage that is intermediate adenoma by the activation of EGFR signaling COX2 EGFR GRB2 FOS PMC2443854__F1 The Essential Components of Nodal SignalingTGFB proteins are synthesized as pre-pro-proteins requiring cleavage of the signal peptide (black) and prodomain (orange) prior to dimerization of active ligand (red diamonds) FOXH1 SMAD2 SMAD4 NODAL GDF1 PMC3637951__F7 FOXM1’s role in thyroid cancer FOXM1 AURKB CCNB1 PLK1 SKP2 PMC8630372__F1 Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine RHEB PIK3CA TSC2 RICTOR TSC1 PIK3R1 PTEN GRB2 MTOR KRAS DEPTOR PMC9271868__F2 Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology LTA LPCAT2 ORAI1 COX1 LTC4S STIM1 TNF PLAA PMC9271868__F1 Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology LPA LTA GPR101 GPR37 LPCAT2 LTC4S PC GPR31 GPR55 LGR6 PMC5991297__F7 Pro-inflammatory AGE-RAGE signaling is activated during arousal from hibernation in ground squirrel adipose HMGB1 JUN NFAT5 S100B PMC2528845__F2 Intracellular signaling activated through FGFRs FRS2 GRB2 SHE PMC5991297__F1 AGE-RAGE signaling can activate ERK1/2 signaling HMGB1 JUN NFAT5 TNF S100B PMC9669388__F2 Astragalus and its formulas as a therapeutic option for fibrotic diseases: Pharmacology and mechanisms BAX FAS KEAP1 GPX4 SMAD2 GSK3B IL33 HEL-S-28 NUMB TNF CTNNB1 GSDMD NLRP3 TLR4 HEL-S-11 SIRT1 NOTCH1 PMC2528845__F4 Opposing signals regulate sex determination in the bipotential gonad SOX9 SRY FGF9 WNT4 FGFR2 PMC8046021__F1 Heparanase triggers multiple pathways that drive myeloma progression HPSE HGF PIR CXCL10 IRS1 PMC7720107__F5 TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation GSK3B ARG1 MYD88 PMC2891025__F6 Deep mRNA Sequencing for In Vivo Functional Analysis of Cardiac Transcriptional Regulators: Application to GAq ABRA ANKRD1 PRMT2 NFATC2 EGFR NRAP ACTA1 MEF2C HEL114 CKAP4 MYOM2 NPPA BTG2 CASQ2 LAMB2 HEL55 CORO2B NPPB RCAN1 PMC7000407__F2 Circadian rhythm in intervertebral disc degeneration: an autophagy connection TSC2 ATG3 ATG12 ULK1 ATF4 MTOR EIF2A ATG5 PMC8692627__F6 Representative mechanisms of tsRNAs in malignancies LATS2 SFMBT1 RUNX1 FZD3 AGO2 DICER1 JAG2 MAP3K7 YBX1 HIF1A NCL PMC8572706__F4 Therapeutic effects of Bombyx mori sericin on rat skin psoriasis through modulated epidermal immunity and attenuated cell proliferation JUN LAT AHR NPB RORA PMC5633085__F6 Tumor-induced osteomalacia FGFR1 MTOR FGF23 PMC6997863__F1 Different pathomechanisms linking DM and AD APOE APP PMC7442608__F4 Folate cycle is coupled to the methionine cycle through distinct mechanisms PHGDH MTHFD2L PSAT1 SLC1A4 HEL-S-51e PSPH PMC3957735__F2 Short-patch base excision repair pathway PCNA UNG PARP1 PMC7318773__F3 Maintenance of Foot-and-Mouth Disease Virus Persistence Inferred From Genes Differentially Expressed in Nasopharyngeal Epithelia of Virus Carriers and Non-carriers RNF128 BAX TBK1 IL10 STAT2 BNIPL CXCL16 IRF3 TRAF3 TRAF6 STAT1 CXCL17 BCL2L1 MAP3K7IP1 NCR3LG1 BCL2L14 TRIM52 NRF NLK NKIRAS1 TRAF2 HIVEP2 PMC7761452__F2 Metazoan MOB proteins present extensive regulation between isotypes LATS1 DOCK8 LATS2 DOCK7 DOCK6 CRLF3 PLK1 FERMT2 PMC3767399__F4 The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp CPO FECH UROD UROS PMC6290938__F10 Proposed mechanisms by which Adam8 deficiency in leukocytes and/or lung parenchymal cells leads to exaggerated cigarette smoke (CS)-induced chronic obstructive pulmonary disease in mice EGFR ADAM8 IL1B PMC9122509__F6 Prostate cancer pathway TF TMPRSS2 BAD PLAT CDKN1B CDK2 BCL2 CYC1 PTEN ERG PMC7926735__F1 Transforming growth factor B (TGFB) signaling regulation by actin remodeling induced by extracellular matrix (ECM) stiffness LEMD3 SMAD2 SMAD4 MRTFA PMC10537408__F8 miRNAs in the HSV-2 infection of macrophages BAX IL10 SOS1 GRB2 MTOR JAK1 TYK2 PMC3153113__F7 Hypoxia Induced Energy Stress Regulates mRNA Translation and Cell Growth RHEB RPS6 TSC2 TSC1 ELF2 EEF2 MTOR EIF2A PMC7441816__F2 PVAT regulates VSMC dilation and contraction EFS PMC11103502__F9 Pharmacological activation of the HIF pathway improves the ischemic tolerance of brain-resident cells by reprogramming of glucose metabolism HEL-S-162eP PMC3687869__F2 Phosphatidylinositol-3-kinase/Akt signaling pathway BAD PTEN PMC11788444__F5 Crosstalk between dysregulation of metal ions and pathological proteins in neurodegenerative diseases CDK5 SP1 APP HTT PMC11788444__F4 Iron dysregulation in the lysosome and mitochondria of PD TF MFN1 MFN2 TFEB FTMT CP PMC3134295__F1 Apoptotic Process BAX APAF1 FADD PMC5127716__F4 Immune signaling cascades triggered by Cryptococcus neoformans recognition SYK NLRP3 BCL10 PLCG2 IL16 IL1B CARD9 PMC6668592__F2A GC/MS and LC/MS-based Tissue Metabolomic Analysis Detected Increased Levels of Antioxidant Metabolites in Colorectal Cancer HEL107 HEL-S-90n PMC7136162__F2 Prevention of atherothrombotic events in patients with diabetes mellitus: from antithrombotic therapies to new-generation glucose-lowering drugs TF HEL-S-62p TFPI TNF PMC6291828__F1 B cell receptor (BCR) signaling pathways SYK CD79B CD79A AXL CARD11 BLNK PTEN CD19 MTOR BTK BCL10 BCR PLCG2 LYN PMC5366820__F2 PDK1 contributes to polarization of signaling downstream to PI3K during cell migration PLCG1 ARHA PMC4327875__F2 Accredited translational medicine centre: Human renal fibrotic disease: Translational research at the Center for Cell Biology and Cancer Research (CCBCR), Albany Medical College, Albany, NY USF2 EGFR ATM PMC5496032__F7 Mechanisms on EET-mediated signaling in response to cardiac hypertrophy and fibrosis TIMP1 IL16 ARHA PMC7883590__F2 Myd88- and TRIF-Dependent Toll Like-Receptor 4 Inflammatory Signaling TBK1 MAL CD14 IRF3 IRAK2 TRAF3 TNF TRAF6 MAP3K7IP1 COX2 TLR4 LBP IL1B PMC99013__F3 Signal transduction cascades regulating pseudohyphal differentiation in S CDC42 TPK1 PMC6158335__F2 Accessory Toxins of Vibrio Pathogens and Their Role in Epithelial Disruption During Infection CFTR HP PMC4650980__F1 Receptor tyrosine kinases and their targeted therapies in gastroesophageal cancers: EGFR, VEGFR and MET EGF HGF EGFR PMC6889937__F5 Proposed action pathway through which Hnk protects cardio-myocytes against Dox-induced senescence NLRP3 TXNIP IL1B PMC6189490__F1 Salvage and de novo synthesis pathways for UTP synthesis UPRT OMP UMPS PMC5357492__F1 Interactions of the AKT signaling pathway with the GSK3B signaling pathways APC GSK3B PTEN PDK2 CTNNB1 PMC6395781__F1 Mammalian O-mannosyl glycans: Biochemistry and glycopathology POMT2 POMT1 FKRP POMGNT2 POMK B3GALNT2 B4GAT1 PMC5852959__F6 CDK5RAP3 - AKT - GSK3B - Beta-catenin pathway in gastric cancer GSK3B CDK5RAP3 LEF1 CTNNB1 PMC5545849__F1 TGFB signaling pathway CDC42 ARHA TGFBR1 PMC2942073__F1 Genetics of Psychosis in Alzheimer Disease: A Review NRG1 SORL1 APOE CHRNA7 PMC11395074__F4 Schematic representation highlights how miRNAs involved in the metastatic process through modulation of key molecular pathways such as TGFB, PI3K/AKT, Wnt/Beta-catenin, JNK/STAT, and Hippo/YAP, which are vital for cancer cell invasion and migration NKD1 STAT3 SIK1 SP1 SMAD2 CD82 CRKL CTNND1 PTEN IL6 AXIN2 CTNNB1 KPNA2 MAP3K2 NCOR2 NRG1 BRF2 ROCK1 ERBB2 DKK2 SOX4 NOTCH1 PMC11395074__F3 miRNAs play a pivotal role in maintaining the delicate balance between cell survival and death by modulating the activity of key pathways such as PI3K/AKT/mTOR, MAPK, TGFB, Wnt/Beta-catenin, and JAK/STAT MAP3K2 STAT3 EGF HGF PBX3 PSD APC ERBB2 MTOR JAK1 CTNNB1 PMC2752373__F1 Selected transformation pathways of tamoxifen and the main CYP enzymes involved CYP2B6 CYP2C19 CYP2C9 PMC5827395__F1 Evasion of the DNA-sensor-mediated IFN-I signal pathway by HSV-1 TBK1 CGAS DDX41 IRF3 PMC8508636__F1 RNA Modifications and Epigenetics in Modulation of Lung Cancer and Pulmonary Diseases MGA FOXM1 TIMP3 ALKBH5 EIF3A YTHDF2 YTHDF1 METTL3 ELF3 PMC5233495__F1 Canonical and non-canonical hippo pathway in ischemic heart disease LATS1 NF2 PMC5636945__F1 Linear modules for conversion of glucose HPR TTN GRN PMC3103528__F5 Inhibitory Actions of Anti-Müllerian Hormone (AMH) on Ovarian Primordial Follicle Assembly ROR1 IFNG THBS1 SP1 BMP3 SMAD4 SKP1 NODAL ARHA TNF PMC6274944__F1 Schematic representation of the extracellular matrix (ECM) components implicated in the regulation of c-MET signaling EGF HGF EGFR PMC7276298__F8 MnTE-2-PyP prevents myofibroblast formation KEAP1 NQO1 PMC11620105__F7 Distribution of key targets in the PI3K/AKT signaling pathway SYK EIF4B BAD RBL2 PTEN CD19 MTOR RAC1 IRS1 EIF4E RHEB TSC2 BCR MDM2 GRB2 PMC2259386__F1 Prototypical myelin-derived neurite growth inhibitors, their receptors and intracellular signaling pathway EGFR LINGO1 RHO PMC6722227__F3 Immunopathology of Trichomoniasis (TV) TH SLPI HEL-S-62p PMC6021006__F6 Salidroside and liver fibrosis CSA2 SMAD4 PMC7509416__F5 p38 functions in neurological and psychiatric disorders TRPV1 HEL-S-44 PMC7593574__F2 Dab2 modulates inflammatory pathways in macrophages and dendritic cells IFNG CD80 CSF1 TLR4 IRF3 IL6 SRC TRAF6 CSF1R MYD88 PMC3110060__F1 MicroRegulators come of age in senescence BMI1 CCNE2 CDK6 HMGA2 IRAK1 CCND1 SIRT1 CDK4 PMC7509416__F1 P38 MAP kinase signaling pathway GSK3B DLG4 ATF1 PMC5748609__F3 ASFV entry and uncoating PAK1 EGFR EEA1 CD63 RAC1 PMC3030591__F4 Comparative Transcriptomic Analysis of Uveal Melanoma and Normal Uveal Melanocyte DUSP10 EGF AKT3 BRAF PRKCZ ATF2 PPP3CA MYC PPP3CC MEF2C PRKCH TGFBR1 TGFBR2 PLA2G10 FGF7A HSPB2-C11orf52 MAP2K6 PRKCE MAF ATF4 GCK IL1B TAOK2 JUN CASP2 ARRB2 CRKL TNFSF6 MAPKAPK2 RASGRF2 IL1A TNF PPP3R2 KRAS FOS HRAS MOS PAK1 IKBKB RAP1A MAPK7 CASP3 TMEM37 NLK MAP2K2 PMC3365480__F1 Pro- and anti-inflammatory effects of heat and heat shock proteins HMGB1 CD14 TRAF6 IL1B PMC3030591__F7 Comparative Transcriptomic Analysis of Uveal Melanoma and Normal Uveal Melanocyte ATR FAS GEM CASP3 CDK2 ATM PTEN PIGS PMC7237311__F5 Brain proteins identified to be interacting with GFP-CASK through GFP-Trap mass spectrometry analysis are plotted using the STRING database interface UGGT1 GAP43 CRMP1 DIRAS2 ATP2A2 TUBB6 CDIPT GDA DUSP3 ABAT HSPD1 RBBP4 LIN7C MAP6 CASK FAM171A2 DKFZp761E1322 MAP1B APC AIP COL11A2 DLAT DISP2 POLA2 PHGDH SKP1 SNTB2 ACR PMC7060278__F4 KEGG maps analysis LPA RAD1 CDA RHOD F2 FES ARHA RND1 VHL PMC3182762__F1 TLR signaling pathways TIRAP IRF7 TRAF6 IRAK4 PMC7060278__F7 LPA metabolism, KLHL and KCNE3 as novel EMT controller genes LPA KCNB1 KCNE3 PLD2 PC KLHL14 LPP PMC8231117__F3 Irisin in Cancer Disease CDH2 STAT3 MTOR PMC4518442__F3 Possible effects of soy isoflavone genistein and tea polyphenolic compound EGCG on the Wnt pathway in breast cancer stem cells APC LRP5 LRP6 CCND1 PMC8231117__F2 Irisin in Cancer Disease CDH2 STAT3 PMC4440769__F11 TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation SHARPIN MAP3K7IP1 TAB3 TRAF1 TRAF2 PMC5833426__F7 Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization STAT3 IL10 MRC1 ARG1 PMC2820080__F5 Transcriptome Profiles of Carcinoma-in-Situ and Invasive Non-Small Cell Lung Cancer as Revealed by SAGE PLAT ECE2 PHYHIP PC RARRES2 PSMD2 PMC2820080__F4 Transcriptome Profiles of Carcinoma-in-Situ and Invasive Non-Small Cell Lung Cancer as Revealed by SAGE NCCRP1 EHD2 TGFBI CCR2 SPARC SFN IGFBP4 DST MGA CD109 FOSL2 PI3 SI PC CDKN3 SRR EGFL7 CSTA SMC4 LTBP2 ADM KRT14 STAB1 NAMPT HEL70 CXCL14 ENG MALL GPNMB HEL-S-102 SBSN GNG11 LIM2 LMNA CNFN YWHAZ PMC11585160__F2 Smad5 Signal Path Diagram DKFZp781O1323 ID2 SMAD4 MYC RUNX2 ID1 ID3 PMC7563548__F11 Partial of the NRF2-mediated Oxidative Stress Response pathway in Fayoumi birds with acute heat stress JUN DNAJA4 PIK3CD FOS POR USP14 DNAJB9 GCLC FGFR1 RASD2 ACTG2 HEL-75 UBB PS1TP5BP1 DNAJC10 PMC7612652__F8 Graphical summary EGFR SRC EIF4E PMC12040833__F10 Pathways (Beta-alanine metabolic pathway; monoterpenoid biosynthesis pathway; glutathione metabolic pathway) enriched by differentially expressed genes (DEGs)/differentially abundant metabolites (DAMs) LAP3 PMC11787465__F4 Intricate signaling pathways and functional networks of miR-23 in tumor cell biology NR1i1 PCDH17 CXCL12 CCL22 FAS HIC1 GLS KEAP1 MSMO1 PTEN RUNX2 PMC11787465__F5 Functional roles of miR-23 in organ development HMGN2 SFRP4 HAS2 PTEN RUNX2 CTNNB1 PMC7497309__F2 FOXO regulation by phosphorylation CDC2 PAK1 CDK2 PMC11809362__F3 Major function of RECK: (A) RECK is a metal protease negative regulatory factor: (a) RECK binds to MT1-MMP and binds it to the GEEC-CLIC endocytic pathway for degradation ADAM17 RECK WNT7A MMP2 ADAM10 CTNNB1 PMC6714079__F4 Central carbon metabolism of T MAL CIT PMC11809362__F2 RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis SP1 RECK PMC7456147__F1 Human placental chorionic villus showing the different trophoblast subtypes: vCTB, STB, and EVTs in the maternal decidua, the latter arising from differentiation of vCTB through the cell column VGLL1 TEAD2 TEAD3 VGLL3 YAP1 TEAD4 PMC9589499__F1 Isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review BAX KEAP1 NQO1 GCLC SRC IL1B PMC9589499__F3 Isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review APOC3 HMGB1 FAS ATF4 IL1B PMC7306093__F2 Schematic representation of Trp metabolism and its influence on Tregs AHR FOXP3 LAG3 PMC5371856__F1 Outer membrane protein-mediated pathogenesis B3GNT5 EGFR TNF PMC7806375__F7 Working model of this study AKT3 GSK3B CTNNB1 PMC6961090__F1 Epidermal growth factor receptor pathway and mechanism of action of osimertinib STAT3 EGF TGFA MTOR JAK1 PMC5803867__F6 TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway NLRP3 ABCG2 PMC8220159__F2 Recent Advances in the Roles of Autophagy and Autophagy Proteins in Host Cells During Toxoplasma gondii Infection and Potential Therapeutic Implications CD40 ULK1 BCL2 PMC9270875__F2 Metabolic Requirements for Pathogen Response GLS HEL-S-133P LDHB PMC8351524__F9 Apolipoprotein C‐II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway ENG GC MMP2 MMP9 PMC7598617__F4 IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis VIT NR1i1 STAT3 NLRP3 IL6 FOXP3 MTOR PMC11831194__F3 Neuroprotective role of OPN in Alzheimer's disease pathology TREM2 SYK MYD88 PMC3543073__F2 Three examples of chromatin-modifying complexes and their mode of action TF HDAC1 BAHD1 PRC1 SETDB1 MBD3 HDAC2 MBD2 PMC9312354__F7 N6-Methyladenosine Methylome Profiling of Muscle and Adipose Tissues Reveals Methylase–mRNA Metabolic Regulatory Networks in Fat Deposition of Rex Rabbits SNAP23 LPL STAT3 MAP4K3 APMAP PTEN YTHDC2 TNMD PCK2 ADCY3 AQP7 FOXO1 Nbla10317 METTL14 PMC3543073__F4 Bacterial nucleomodulins targeting chromatin BAHD1 CYBB PMC5868510__F5 The molecular mechanism by which miR-134 aggravates atherogenesisMiR-134 downregulates ANGPTL4 expression by directly binding to the 3′UTR of ANGPTL4, leading to increased expression and activity of LPL LPL ANGPTL4 PMC9515028__F2 Possible role of long non-coding RNAs in recurrent miscarriage MXD1 IL18 SLC4A11 CDK2 ITGB3 CXCL8 CTNNB1 EIF4E PMC4654680__F1 Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer SNAI2 PATJ PARG SOX2 AMOTL2 TBX5 AREG NOTCH2 VGLL4 BIRC5 LATS2 SCRIB NF2 PMC11060011__F8 Molecular action schematic DKK3 TCF4 METTL3 MFF CTNNB1 PMC4654680__F4 Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer LATS1 LATS2 NF2 CTNNB1 PMC4910294__F2 Differentially expressed proteins involved in the pathway of Alzheimer׳s disease LPL IDE CASP9 BAD APOE GSK3B CASP3 SNCA APP TNF FADD PMC12164340__F6 Alpha-Linolenic Acid from Zanthoxylum Seed Powder Regulates Fatty Acid Metabolism and Influences Meat Quality of Pekin Duck via the ADIPOQ/AMPK/CPT‑1 Pathway LPL FABP5 CD36 PMC5808733__F7 Activation of the JAK-STAT pathway by viruses and the biogenesis, fission and fusion life cycle of mitochondria STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC8548342__F5 MinION sequencing from sea ice cryoconites leads to de novo genome reconstruction from metagenomes POR PDC SMO FLG PMC3669661__F2 Phosphatidic Acid and Lipid Sensing by mTOR LPA HEL-S-5 PC PMC3669661__F1 Phosphatidic Acid and Lipid Sensing by mTOR RHEB TSC2 TSC1 PTEN MTOR PMC5204211__F1 The status of Nrf2-based therapeutics: current perspectives and future prospects RBX1 BACH1 KEAP1 MAF PMC3408695__F1 Part of the metabolic pathway of estradiol and the role of various enzymes involved: Estradiol is metabolized into 2-hydroxyestradiol (2-OHE2) and 4-hdroxyestradiol (4-OHE2) by CYP1A1 and CYP1B1 respectively NQO1 CYP1B1 CYP1A1 PMC2806519__F8 Prostaglandin F2Alpha-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium–calcineurin–NFAT pathway IL8RB RCAN1 CXCL8 RCAN3 PMC3369817__F8 Pathway diagram of the cyanobacterial core metabolic network HEL107 RPE HEL-S-162eP MAL CS CIT PMC7290734__F2 Type 2 immune response via ILC2s in asthma patients IL25 TSLP IL33 PMC6099186__F2 The role played by TCL1 in multiple signaling pathways SYK TSC2 BTK TSC1 BCR TP63 ATM EP300 LYN MTOR XBP1 PMC3777916__F3 Using Biological Pathway Data with Paxtools RPE RPIA PMC3777916__F2 Using Biological Pathway Data with Paxtools GNG2 GNB1 PMC3247963__F7 Model illustrating that early and late ISGs induction is regulated by multiple STAT1 posttranslational modifications IFNAR2 IFNAR1 TYK2 PMC5745837__F7 Molecular interactions in the Akt/mTOR signaling pathway.IP3K: Inositol-triphosphate 3-kinase; PDK: phosphoinositide-dependent kinase; TSC: tuberous sclerosis complex; Rheb: Ras homolog enriched in brain; mTOR: mammalian target of rapamycin RHEB TSC2 TSC1 C2 MTOR PMC8708596__F4 An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKT RHEB TSC2 TSC1 PTEN GRB2 PMC25571__F9 A model of cnxPg action TCF3 APC POP1 PMC9198215__F2 Sirtuins in Osteogenic Differentiation of Vascular Smooth Muscle Cells and Vascular Calcification SIRT3 ATM RUNX2 SIRT1 CTNNB1 SIRT6 PMC3165779__F3 Cellular PA-interaction networks RAN TNPO3 IPO11 TNPO1 MMS19 EGFR CTNND1 CIAO1 ACACA HSD17B12 KPNA2 STAT1 PRPF6 MAP2K4 TNFAIP2 MYO1C COPB2 AIMP2 DYNC1H1 HEL-S-101 SLIRP FASN EEF1G FLJ10842 COPA XPO7 KDELR1 GBF1 SLC25A11 PRKDC STOM DPM1 NUP93 RAB1B XPOT TUBG2 PMC7839487__F1 Intermediate filaments cross talk with different signaling pathways GFAP SMAD2 APC MSC SMAD4 CTNNB1 TGFBR1 PMC6288394__F1 Summary of the potential mechanisms of vaccine NSEs NOD2 MTOR IL1B PMC3764329__F2 Metabolic pathways for fatty acid and acetate utilization CS PMC10965438__F13 Nanomaterials modulating TAMs polarization for the treatment of pancreatic cancer NPS TLR4 BCL2 CD163 PMC6188698__F1 Regulation of Neurogenesis by DISC1 GSK3B PDE4B AXIN2 DISC1 NDEL1 FEZ1 CTNNB1 PMC10965438__F15 Macrophage membrane-coated nanomaterials and macrophage-based microrobot for the treatment of digestive system tumor HMGB1 NPS EGFR MTOR PMC6190866__F6 Differentially regulated genes by IRF7 overexpression upon H6N2 infection MAFK PCDH18 DTX2 CHAC1 NFATC2 ADPRM MSMO1 HTRA1 APC2 INAFM2 POSTN OSBPL7 ALDH1A3 FOXC2 PIM3 ID4 RBM12 ATN1 FDPS IL11 CEBPB RASA4 ACVR2A JDP2 MAK ADAMTS5 CALN1 DAAM2 SKI ID1 RSPO1 DKK3 GFAP PAPSS2 GRAP APCDD1 HDAC9 HLF PMC5834288__F5 Myostatin regulates phosphorylation of key enzymes in glycogen metabolism and glycolysis pathway PHKA1 PYGM GDF8 HEL-S-133P GSK3B LDHB HEL-S-30 ENO3 FBP2 HEL-S-68p PHKB GYS1 PAK1 HEL-S-162eP AGL HEL-S-87p PFKM PMC8168458__F1 Crosstalk between metabolic pathways and the tissues in which they are implicated in aging regulation IGF1 INSR NAMPT PTEN SIRT1 IRS1 CRTC1 PMC6642871__F2 The glycolytic switch in different cell types MTOR PMC7531435__F1 Key Figure TH KIF21A RHO PMC8301451__F1 Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer SMAD1 JUN DKFZp781O1323 SMAD2 SMAD6 SMAD4 TNF UNK PMC4975146__F3 Signal transducer and activator of transcription tyrosine kinase domain c-Kit in cancer cell.Notes: The Ras-Erk pathway, PI3K/AKT pathway, and Src-signaling pathway have been demonstrated in this schematic picture SOCS1 SOCS2 BCL2 PTEN SOCS3 GRB2 SRC CCND1 PMC7585454__F3 Myocardial Phosphodiesterases and their Role in cGMP Regulation RGS2 TSC2 PDE9A TSC1 PDE5A GCA TRPC6 TRPC3 PMC4975146__F2 Signal transducer and activator of transcription tyrosine kinase domain c-Kit in normal cell.Notes: Ras/Erk pathway directs to activate of the proliferation genes GRB2 MTOR PMC2666391__F2 Toll-Like Receptors and Corneal Innate Immunity LTA TLR3 TLR4 TLR9 TLR8 CD14 TLR5 TLR7 IL6 MYD88 PMC6058517__F1 Schematic representation of the rough PTX-PLGA-MS fabrication technique, tumor site injection and intracellular drug delivery pathway CCNB1 CCND1 PMC5624538__F1 Role of FXR in Liver Inflammation during Nonalcoholic Steatohepatitis CXCL2 LCN2 CCL2 TNF PMC4077879__F1 Selective autophagy against membranous compartments ATG16L1 TMEM59 ATG14 RB1CC1 BNIP3L PMC1892626__F3 Regulation of hypoxia-inducible factor-1A (HIF-1A) and drug interventions currently in use EGFR PTEN MTOR CXCR4 VHL PMC11677460__F10 Hypothetical model MSC SLC7A11 PMC7734207__F2 Schematic diagram of the regulation of mitochondrial apoptosis, Wnt/Beta-catenin, JAK-STAT, and PI3K/AKT signaling pathways via different miRNAs in various human cancers STAT3 BAX BAD IFNGR1 APC TCF4 SOCS3 CTNNB1 RHEB STAT1 IFNGR2 TSC2 FOXM1 FRAT1 FZD4 TSC1 APAF1 CCND1 PMC5520878__F8 Schematic diagram illustrating signaling of EZH2 and its upstream activator and its downstream effectors in GC SP1 EZH2 CCND1 PMC11814426__F1 miMOMP activates mtDNA-cGAS-STING pathway and promotes cellular senescence and tissue aging BAX IL1A IL6 PMC7963035__F1 NAD+ metabolism and its roles in cellular processes during ageing SIRT7 NAPRT HEL-S-90n NMNAT1 KYNU SIRT4 SIRT5 NMNAT2 NAMPT SIRT2 SLC7A5 SLC12A8 SLC22A13 SLC5A8 SIRT3 SARM1 SLC36A4 SLC25A51 NADK SIRT1 NMNAT3 SIRT6 PMC2711774__F2 Proposed biosynthetic pathway for the disorazoles ACP2 HEL-S-5 ACP3 CP PMC2888641__F1 Targeting Hedgehog - a Cancer Stem Cell Pathway PTCH1 SMO GLI3 PMC7880682__F6 Effect of curcumin mediated by PPARa in mouse liver C6 NR1C1 PMC6858476__F1 Schematic overview of steroidogenesis and corresponding urine steroid metabolites HSD3B2 CYP21A2 HSD17B3 CYP17A1 STAR CYP11B2 EPO HSD11B1 POR PAPSS2 CYP11A1 HSD11B2 HSD17B2 SULT2A1 PMC3411916__F3 [LM5]Strategies for treatment of traumatic central nervous system (CNS) injuries TSC2 TSC1 PTEN SOCS3 MTOR PMC4852799__F1 Appropriate activation and feedback control of TP53 activity is critical to effective tumor suppression RFWD2 ATR ATM PMC11506335__F3 Comparison of ATR activation and signaling pathway in interphase and in mitosis CDC2 TOPBP1 ATR ATRIP ETAA1 WEE1 PMC10215119__F1 Mechanisms involved in the regulation of macrophage polarization by exosomal ncRNA in AS KLF4 STAT3 ABCG1 IGF2BP1 HMGA2 KLF6 BMP4 PTEN ABCA1 PMC9231089__F15 Sorafenib Chemosensitization by Caryophyllane Sesquiterpenes in Liver, Biliary, and Pancreatic Cancer Cells: The Role of STAT3/ABC Transporter Axis STAT3 EGF PGP EGFR SRC PMC8097443__F7 Ethylzingerone, a Novel Compound with Antifungal Activity EN2 tal-1 ENO2 ENO1 PMC3787764__F8 Proposed molecular pathway governing multiciliogenesis MYB FOXJ1 MCC PMC9312280__F4 Evaluation of Proanthocyanidins from Kiwi Leaves (Actinidia chinensis) against Caco-2 Cells Oxidative Stress through Nrf2-ARE Signaling Pathway BAX KEAP1 MAF PMC5731897__F3 Transcriptomic pathway analysis of urokinase receptor silenced breast cancer cells: a microarray study MAX MAPK1 CD40 STAT3 ADM PLAUR CTNND1 BRAF FHL2 NAMPT PTEN LPAR1 PTGS2 CYP1B1 PRKCH XPC NRG1 INHBA FBLN5 APLN MMP3 HAS2 HEL2 PMC6028781__F4 Central carbon and nitrogen metabolism of Arabidopsis thaliana active in most growth stages and conditions simulated MAL GIP CP CIT PMC4925073__F1 Pathway of codeine metabolism in a CYP2D6 extensive metabolizer UGT1A1 UGT2B7 PMC7531435__F3 Integrins Control Vesicular Trafficking; New Tricks for Old Dogs NUMB ARHA PMC8254040__F1 Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection NDC1 NUP133 NUP155 NUP85 RAN NUP107 NUP214 NUP35 NUP88 NUP205 POM121 NUP188 NUP160 NUP62 TPR NUP153 NUP93 NXT1 RAE1 NUP54 NUP98 NUP58 PMC3492658__F1 NOD1 and NOD2 signaling pathways and interaction partners RIPK2 MAVS NLRP3 ATG12 NOD2 DAP IRF3 NOD1 ATG5 IL1B CARD9 PMC4846800__F2 Resistance mechanisms in MAPK-inhibitor treated melanoma BCL2A1 NF1 BRAF CDK2 CDK4 PMC4379579__F9 Fate of plasmids and their expressed antigens after electroporation (A); The Fas/FasL signaling pathway and some of the key molecules involved (B) FAS APC FADD PMC4258820__F1 Representative ARG biosynthesis routes in prokaryotes AGA CIT PMC3260860__F6 Scheme of the EGR-1/GGPPS/ERK 1/2 pathway EGR1 GRB2 PMC7593815__F2 Illustration of the cellular context and key processes in which MPEG1 is implicated IFNG TNF MYD88 PMC11653477__F1 Physical exercise-mediated neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and epilepsy IGF1 KEAP1 BDNF SIRT1 PMC3021368__F5 Foxo3 controls DCs functions FOXO3A BCL2 CTLA4 PMC8661833__F2 Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity GPC4 RAX2 TLR3 GLA SELP IMPACT PMC3943226__F1 Apoptosis signaling pathway BAX BIRC6 CAD ROCK1 BCL2 TNF DIABLO PMC10478613__F2 Structure and function of kartogenin DKFZp781O1323 RUNX1 CBFB BMP7 RUNX2 CTNNB1 PMC8732860__F7 Inhibition of HMGB1 Ameliorates the Maternal-Fetal Interface Destruction in Unexplained Recurrent Spontaneous Abortion by Suppressing Pyroptosis Activation HMGB1 GSDMD NLRP3 PMC6769940__F1 Interference of hepatitis C virus (HCV) with the nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)/ Keap1-signaling pathway CYP2E1 IGF1 KEAP1 MAF IGF1R ERO1A MTOR IRS1 PMC6613992__F1 Endogenous oxalate synthesis pathway in hepatocytes GLO1 DAO PMC4762423__F1 Metabolism reprogramming in PDAC RPE RPIA HEL-S-133P GFPT1 ME1 MYC KRAS PMC8739690__F5 Transcriptomics analysis reveals the signal transduction mechanism of brassinolides in tea leaves and its regulation on the growth and development of Camellia sinensis IWS1 BIN2 ELF4 BAK1 PMC5784953__F7 Critical comparison of topology-based pathway analysis methods EGF PIK3CA BAD TGFA SOS1 RASSF1 EGFR BRAF STK4 RXRG PRKCB PLCG1 ALK PLCG2 RARB PDPK1 PRKCA RXRB KRAS ARAF HRAS SOS2 RXRA ERBB2 GRB2 PMC9302576__F1 Metabolic Reprogramming Induces Macrophage Polarization in the Tumor Microenvironment STAT3 STAT1 TLR4 IRAK2 PMC4130202__F2 New molecules targeting angiogenesis and crosstalks between angiogenesis and tumor microenvironment VEGFB PIGF VEGFA PMC309687__F10 Postsenescence survival in telomerase-deficient (tlc1Δ) budding yeast cells is controlled by three distinct Rad52-based homologous recombination pathways RAD52 RAD50 CIB2 RAD51 PMC1782192__F2 Direct and indirect activation of human natural killer (NK) cells TLR3 TLR7 PMC3854201__F4 Biological interaction networking of PSME1 and RPS12 in chronic atrophic gastritis (CAG) NPPC RPS6 RAF1 F5 IKBKE BRAF TNF MIA ENG ChAT RPS12 HLA-B CCND1 IL1B PMC4675703__F1 Therapeutic control of complement activation at the level of the central component C3 HEL-S-62p C2 CS PMC5193490__F2 Nrf2 affects mitochondrial function at multiple levels FAS ME1 HEL-S-26 PMC9160246__F3 Neuroinflammation in PD CX3CL1 IL6 TNF IL1B PMC6928941__F2 Ca2+ is mostly involved in mTOR-independent autophagy induction VIT LRRK2 TFEB AMBRA1 ATG14 HEL-S-11 MTOR PMC6166529__F1 Cancer Genome Atlas of glioblastoma multiforme RB1 MDM4 CDK6 CDKN2C CCND2 NF1 EGFR PDGFRA ERBB2 PTEN MDM2 CDK4 PMC7405025__F2 Pathogenesis and management of myocardial injury in coronavirus disease 2019 TMPRSS2 CCL2 TNF ACE2 PMC9160246__F9 Mechanistic view of roles of different K+-channels in the diagnosis and treatment of the PD pathogenesis POR JUN GDNF PMC3368264__F1 An overview of the folate metabolism pathway in formation of essential intermediates in Leishmania FTL DHFR PMC11013124__F1 Neuroinflammation of Microglial Regulation in Alzheimer’s Disease: Therapeutic Approaches TREM2 NLRP3 MTOR PMC7699002__F1 Sulfur Metabolism Under Stress CTH FES MTR HEL-75 PMC9650603__F2 FOXK2 transcription factor and its roles in tumorigenesis (Review) BARD1 SAP30 JUN SIN3A TET1 BAP1 FOXK2 HDAC2 FOS CTNNB1 PMC10760828__F9 Schematic representation of overall outcome of the study SP100 PML PMC8001769__F2 Schematic view of controlling cancer hallmarks and associated signaling pathway by lncRNAs ATM IGF1R MTOR PMC6497095__F9 Schematic view of signaling events elicited by LPS in RPE cells RPE PLD2 PC PMC5006627__F1 Interaction between the canonical WNT signaling pathway and other signaling pathways implicated in MPNST tumorigenesis BIRC5 TNKS APC GSK3B LRP5 LRP6 PTEN MYC CXCR4 CCND1 LEF1 CTNNB1 PMC11351389__F3 Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review GSK3B LRP5 MSC LRP6 AXIN2 CTNNB1 PMC11641583__F2 YAP activation in KCs KLF4 ARID1A KRT5 MOB2 THY1 EGFR KRT14 ANXA2 PKP1 DSG1 AREG DSG3 TEAD4 LATS1 LATS2 PKP4 TEAD2 TEAD3 NF2 SRC PMC4344549__F1 Canonical Wnt signaling DKK1 APC LRP6 CTNNB1 PMC4440880__F1 Activation and targeting of prosurvival pathways mediating FLT3 resistance FLT3 CXCL12 PIM1 MTOR CXCR4 PMC9459503__F6 Histone methyltransferase KMT2D mediated lipid metabolism via peroxisome proliferator-activated receptor gamma in prostate cancer ACLY MLL2 FASN PMC11351389__F2 Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review BGLAP SP7 RUNX2 FGF23 PMC5343023__F3 Fatty acid (FA) and cholesterol sensing in T cell immune responses FOXP3 PMC9236130__F1 Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer LPA RHO PMC8762220__F2 Altered BMP2/4 Signaling in Stem Cells and Their Niche: Different Cancers but Similar Mechanisms, the Example of Myeloid Leukemia and Breast Cancer STOM BMP4 MSC TWIST1 PMC9005057__F1 SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides PNP CLU UMPS PMC2918880__F1 Schematic depiction of selected core elements of the unfolded protein response (UPR), featuring the components measured herein (; ; ; ) BCL2 EIF2A XBP1 PMC5528145__F2 Mechanistic association of insulin signaling with mitochondrial function in normal and diabetic brain GSK3A GSK3B BDNF SIRT1 PMC3021368__F2 PI3K in immune system ICOS BCR CD19 PMC8966389__F3 Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved CDC2 TBK1 STAT1 MAVS STAT2 IFNAR2 IRF9 IFNAR1 IRF3 JAK1 CCNB1 TYK2 PMC11641583__F3 YAP and TAZ interactions with signalling pathways and TFs KLF4 FUS BRD4 SNAI2 SMAD1 WNT16 DKFZp781O1323 AXL EGFR SMAD2 GSK3B SMAD4 LRP6 TGFBR3 AREG VGLL4 CTNNB1 FGFR2 CTCF SNAI1 SHH P2RY6 SRC DLL3 PMC9236130__F2 Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer LPA STAT3 HGF LPAR2 HIF1A LPAR1 MTOR SRC TRIP6 LPAR3 PMC5585656__F1 Proposed role of molecular and small molecule chaperones in proteostasis HEL-S-72p HEL-S-89n PMC9159919__F7 Acute Intoxication With Alcohol Reduces Trauma-Induced Proinflammatory Response and Barrier Breakdown in the Lung via the Wnt/Beta-Catenin Signaling Pathway SOST APC dik CXCL1 CTNNB1 PMC9340220__F1 Antioxidants in Human Milk on Bronchopulmonary Dysplasia Prevention and Treatment: A Review TXN SENP1 NQO1 SIRT1 PMC5519008__F2 lumpGEM: Systematic generation of subnetworks and elementally balanced lumped reactions for the biosynthesis of target metabolites PIG59 ME2 HAO1 MAL HEL-S-11 CS ME1 TNLG7C ADA CIT PMC3116598__F1 p21-activated kinases in Erbb2-positive breast cancer ERBB2 MTOR MYC PMC3467778__F3 Skewed Th17/Treg cell differentiation in patients with BD, a hypothesis STAT3 RORC SMAD2 FOXP3 PMC2992967__F2 Sonic hedgehog (SHH) pathway BAMBI SUFU PTCH1 SHH SMO IGFBP2 MYC HES1 SFRP1 GLI3 PMC5894198__F8 Schematic diagram of GDF15 activating the PI3K/AKT and MAPK pathway in cervical cancer progression CCNE1 GDF15 ERBB2 CDK2 MYC CCND1 CDK4 PMC8304001__F1 Prostate Cancer Therapy Enzalutamide Compared with Abiraterone Acetate/Prednisone Impacts Motivation for Exploration, Spatial Learning and Alters Dopaminergic Transmission in Aged Castrated Mice CYP17A1 CYP11A1 SULT2A1 STS PMC10869801__F0 Macrophage TSC1-mediated AKT/MST1/NRF2 signaling pathway in I/R-triggered liver inflammation HMGB1 TSC1 KEAP1 TLR4 TRAF6 PMC6052671__F1 TGFB1 signaling cascade leading to EMT CDH2 SMAD2 SMAD4 CFTR PMC2849646__F3 Frequent amplification and overexpression of multiple EGFR-family-signaling components in non-small cell lung cancer (NSCLC) CDK5 SHC1 EGFR GRB2 PMC11609662__F8 Metabolic pathway map of detected metabolites FAS OMP HEL-S-5 PMC6044387__F5 The two co-occurring pathways in PDAC that are predicted to drive oncogenesis based on the mutational landscape representing two common driver pathways PIK3CA PIK3R1 PHF24 BRAF PTEN CDKN2B MTOR MYC RB1 MDM4 CDKN2A CDK6 CCND2 PI3 ATM MDM2 PRG4 RPTOR CASP8 ERBB4 KRAS FOS SET ERBB3 TSC2 TSC1 BRCA1 FOXO3A PDGFRA BCL2 EP300 PMC6044387__F6 MAPK heat diffusion sub-network: pathway extracted from the TieDIE subnetwork using heat diffusion analysis from the MAPK1 network node EGF SHC1 SOS1 AGAP2 EGFR JAK3 IL2RG RPS6KA1 ATF2 HDAC3 MAPK14 BTK MAP2K6 MAPK1 JUN MAPKAPK2 CD19 FOS ATF3 CBL MAP3K1 NFKB1 RELA NTRK1 NFKBIA SH3GL2 RPS6KA3 MAP2K2 GRB2 RPS6KA5 PMC5079184__F3 IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction STAT3 JAK3 GRB2 IL15RA PMC8388923__F7 Nepetoidin B from Salvia plebeia R. Br. Inhibits Inflammation by Modulating the NFKB and Nrf2/HO-1 Signaling Pathways in Macrophage Cells KEAP1 TNF PMC10618387__F5 Crosstalk between the signaling pathway of pyroptosis, apoptosis, and autophagy GSDMD NLRP3 MTOR SESN2 PMC8515020__F1 Hyperinflammatory Immune Response and COVID-19: A Double Edged Sword IFNG TH HMGB1 GSDMD NLRP3 TLR3 CCL3 TLR4 CCL7 CCL5 CCL2 PMC3317017__F4 Altered signaling pathways and inhibitors EGFR APC SHH SMO PTEN PMC8637543__F2 Zinc Finger Proteins in Neuro-Related Diseases Progression TIEG2 KLF2 CLDND1 MZF1 PMC10618387__F3 Apoptosis is mediated by intrinsic and extrinsic pathways BAD FAS GSDMD TRADD CYLD FADD PMC2665727__F5 Ty retrotransposition cycle RAD52 LSM1 DCP2 LSM3 XRN1 LSM5 DBR1 LSM7 LSM6 LSM4 LSM2 PMC8194305__F4 Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions STAT3 IL17RC TRADD MLKL JAK3 TRAF6 IRAK4 MYD88 IL1R1 STAT1 STAT4 JAK1 TRAF2 TYK2 PMC6823372__F3 KEGG pathways involved in the lipid methabolism of zebrafish enriched after MPs exposure PRND DAP PMC6322225__F2 Health to disease (HTD) network NPAS2 PTK6 LAT TNF PMC6834863__F2 The different apelinergic signaling pathways SIRT3 F3 FABP4 KDR VEGFA ACE2 PMC4594611__F1 Hypothetical Model for the Transduction of Synaptic Stimuli to Long-Term Plasticity POLI MTOR PARP1 PMC4409285__F1 Schematic intracellular network required for lipid metabolism, Apo B biogenesis, and CM assembly in the enterocyte TG ACAT2 APOB PMC8745771__F3 Rigosertib and Cholangiocarcinoma: A Cell Cycle Affair CDC2 WEE1 PLK1 PMC6268691__F1 Biosynthesis pathway for gangliosides GATC GAL ST8SIA1 B3GALT4 PMC7483331__F2 Protein signaling networks regulating autophagy ATG101 STAT3 ATG12 SRC CD63 PMC1555658__F2 Cholesterol precursors and facial clefting SHH SMO PMC2922518__F1 Schematic illustration depicting the cellular pathways that lead to eIF4E activation and phosphorylation by Mnk1/2 RHEB TSC2 TSC1 MCL1 CCL7 MMP3 PTEN MMP9 CCL2 ELF3 EIF4E PMC4211376__F7 DAPK2 is a novel modulator of TRAIL-induced apoptosis BAX DAPK2 APAF1 DIABLO FADD PMC8745771__F1 Rigosertib and Cholangiocarcinoma: A Cell Cycle Affair CDC2 CDC20 APC PLK1 PMC5709754__F1 CD30 mediates its effects through a number of diverse signaling pathways, which in concert confer a survival benefit to the cells on which CD30 is upregulated JUNB TRAF1 TRAF2 PMC8534091__F1 Intersection of Purine and Mitochondrial Metabolism in Cancer APRT PAICS MTHFD1 GOT2 ADSL PMC6877939__F1 Overview of PI3K/AKT/mTOR signaling pathway and downstream effects PI3 EGFR PTEN PMC6918475__F1 Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs CYP8B1 CYP7A1 GCA PMC3403084__F5 Necrosis signaling pathways TRADD MLKL TNF CYLD TRAF2 FADD PMC9331965__F1 IRIDA Phenotype in TMPRSS6 Monoallelic-Affected Patients: Toward a Better Understanding of the Pathophysiology TF ERFE STAT3 BMP6 TFR2 SMAD4 HFE IL6 PS1TP5BP1 PMC5393505__F3 Network of damaging mutations in ACC associates to the TP53 pathway SIX1 RHOBTB1 EPHB6 NF2 TERF1 PMC2808316__F5 Metabolic model for Aspergillus niger INA MAL PMC5715147__F1 Schematic of albumin/AlbiVax nanocomplexes for efficient vaccine delivery and combination cancer immunotherapy HEL-S-92n APC PMC10528955__F1 Neuroinflammation: A Modifiable Pathway Linking Obesity, Alzheimer’s disease, and Depression TG TLR4 IL1B PMC11083345__F5 DEGs and DEPs involved in Alpha-linolenic acid metabolism, terpenoid biosynthesis and phenylalanine metabolism pathway MAX LOX PMVK MVD PMC5997167__F3 Gene networks involved in the analyses of males with HCB exposure PCGF2 GLA ACD PMC3065826__F1 Metabolism, Cell Surface Organization, and Disease MGAT5 MGAT1 GAL EGFR MGAT2 PMC5997167__F5 Networks involved in the analyses involving males with nPFOS exposure CD2 GAP43 TSKS FAM133B REPS2 CCNB3 NAA25 RB1 TAF1 UBL3 GRAMD4 FGF20 ERMN BRD2 PMC3546058__F1 DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the omega-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways PPARG NR1C1 CFH APP ABCA1 PMC8836889__F1 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review BAX MCL1 BCL2 ATM MDM2 APAF1 PMC2517789__F2 Two pathways from gp130 to hypertrophic gene expression STAT3 STAT1 LIF PMC2517789__F1 Cytokines and their receptors in cardiovascular diseases CNTFR CNTF OSM OSMR LIF PMC8807626__F3 Context-dependent modulation of TGFB pathway by LRG1 HMFT1766 SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC8745569__F1 Intriguing Thyroid Hormones–Lung Cancer Association as Exemplification of the Thyroid Hormones–Cancer Association: Three Decades of Evolving Research TRO CRYM MTOR PMC8836889__F5 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review BAX BCL2 PTEN PMC8836889__F3 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review GSK3B BCL2 MTOR PMC8836889__F2 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review FAS FADD PMC7925333__F3 Major intestinal host defense pathways identified in C. elegans ATF5 FOXO3A TFEB ATF7 HIF1A XBP1 PMC3116140__F2 The core pathway of Notch signaling NUMB HES1 RBPJ HES5 PMC5893262__F3 TCR complex activation LAT GRB2 TNF FOS PMC3542954__F1 Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosisEBV infection disrupts normal cell death and survival pathways in various human tumor cells, including lymphocytes, fibroblasts, and epithelial cells IFNG FAS CD74 BCR BCL2 PMC4670612__F10 Ingenuity Pathway Analysis of the subset of day-one genes that differentiate long-term success or failure, divided into two groups (F and G) following an unsupervised cluster analysis KLK14 SYNGR3 GGT7 MYC DNAJC22 PGAP1 NOL9 CWC27 HEL-S-308 RB1 ADAM21 GPR89B TBRG1 CDKN2A ARL17B DNAJB3 KCNN1 ZNF568 RHBDL3 F2 TMEM184B SAMD4A HEL55 DONSON FAM86B1 AP1AR MATN1 CFL2 UTP15 MCM9 EIF4B UBC SLC26A11 DKFZp667O1614 CYB5R1 CMAS TNF DMBX1 RAC1 CPA4 ADK ADRB2 ZNF431 FAM111A PMC8147474__F3 Maintenance of Skeletal Muscle to Counteract Sarcopenia in Patients with Advanced Chronic Kidney Disease and Especially Those Undergoing Hemodialysis NR1i1 SMAD2 PMC9389749__F1 Transfection with Plasmid-Encoding lncRNA-SLERCC nanoparticle-mediated delivery suppressed tumor progression in renal cell carcinoma BMI1 VEGFA MUC12 PMC9586778__F4 Network Pharmacology-Based Exploration on the Intervention of Qinghao Biejia Decoction on the Inflammation-Carcinoma Transformation Process of Chronic Liver Disease via MAPK and PI3k/AKT Pathway HRAS STAT3 PIK3CA EGFR CREBBP APP EP300 ARHA VEGFA SRC LCK MAPK3 PMC6363635__F1 Pathways to DHT synthesis (modified from Ref HSD17B3 HSD17B6 CYP17A1 DHRS9 HSD17B1 HSD17B2 RDH5 AKR1C2 PMC9370349__F1 Alleviating Effects of Black Soybean Peptide on Oxidative Stress Injury Induced by Lead in PC12 Cells via Keap1/Nrf2/TXNIP Signaling Pathway KEAP1 TXNIP PMC6621164__F9 Model of the function of CTTNBP2 at dendritic spines CTTNBP2 SRC RAC1 PMC8125491__F3 Epigenetic Regulation of Neuroinflammation in Parkinson’s Disease LRRK2 SNCA PMC6131612__F1 PI3K/Akt signaling pathway in HI BAX BCL2 PTEN MTOR PMC5923353__F1 Lytic cycle proteins contribution to tumor initiation and tumor maintenance through enhanced survival, inflammation and immunomodulation CXCL12 COX2 IL16 CXCR4 IL1B PMC6147765__F3 Different modalities of cell death ATG10 FAS ATG3 ATG12 GPX4 CASP3 IL18 RHO ATG5 FADD PMC3247287__F8 Profiling Insulin Like Factor 3 (INSL3) Signaling in Human Osteoblasts PLCB3 SRC CTNNB1 RXFP2 PMC5597216__F1 Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages VIP TRH GAL EGR1 CGA LAMA1 LHB HAPLN1 GHRH VEGFA NCOA1 IGF2 FSHB PRL PRKCA POMC IL2 LHX3 CP PMC3863956__F1 Using PainNetworks to reproduce the NGF-TrkA signalling pathway HRAS NGF SOST SHC1 GRB2 PMC6937654__F1 miRNAs regulate the HSC activation and schistosomiasis liver fibrosis through modulating TGFB/SMAD signaling pathway NR1i1 TGFB1 SMAD2 SMAD4 COL3A1 PMC10473946__F1 Impact of inhaled and intranasal corticosteroids on glucose metabolism and diabetes mellitus: A mini review ANGPTL4 GC IRS1 PMC7895386__F5 Wide range of metabolic adaptations to the acquisition of the Calvin cycle revealed by comparison of microbial genomes HEL107 MAL TNLG7C CIT PMC8145311__F7 Distinguishing Alzheimer’s Disease Patients and Biochemical Phenotype Analysis Using a Novel Serum Profiling Platform: Potential Involvement of the VWF/ADAMTS13 Axis LTBP1 LRP4 UPF2 PARP4 HSPG2 TNFAIP3 BOC AGAP2 GRN ITGAX CR1 EYA1 CTCF GATAD2A NAAA ZNF592 POU4F3 ARHGEF2 CYLD POTEB2 LTBP2 POTEB3 VWF ASCC1 YEATS2 EGR1 KHSRP CAPN3 ATP1A1 hEMMPRIN RIF1 SNTB2 ADAMTS13 TSHZ2 PMC8890945__F6 Inhibitory effect on melanogenesis via PKA/CREB/MITF axis by DPN MC1R PMC11885516__F2 Dual role of reactive astrocytes IL1R1 ROCK2 ROR2 TNF HES1 NOTCH1 PMC8876623__F1 mTOR Signaling and Potential Therapeutic Targeting in Meningioma RHEB CD44 MLST8 TSC1 PTEN NF2 DEPTOR PMC4646847__F4 Oligonucleotide discriminators of the TLR9-cholinergic links ACHE TLR9 BCHE PMC8111166__F2 Kynurenine pathway KYNU KMO AFMID PMC6021586__F5 Potential effects of miR-143 and miR-135a on signaling pathways MUC5AC IL13RA1 GATA3 PMC7879635__F9 Signaling pathways affected by exosomal miR-199a-3p/145-5p NGF CBL CD27 CD9 CD63 PMC8073974__F7 Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling LPA KPG_010 TGFBR1 PMC8237754__F1 Epigenetic Regulation of Autophagy Beyond the Cytoplasm: A Review BRD4 FOXO1 HEL-S-162eP SIRT1 PMC4754913__F3 Diagram summarizing the reviewed mechanisms by which CCR9 induces different aspects of tumor metastasis CCL25 ARHA PMC8960601__F2 Immunomodulatory Activity of Mesenchymal Stem Cells in Lupus Nephritis: Advances and Applications STAT3 PDC MSC CCL2 CXCR4 PMC4318143__F8 A Dlg5-mediated bifurcation in Smo activity during Hh response GPR161 DLG5 KIF7 SMO GLI3 PMC5182003__F2 AKT signaling pathway map CD44 CASP9 BAD TGFA EGFR APC GSK3B KIT MDM2 MTOR MYC CTNNB1 PMC2759144__F4 Model depicting the E2Fs-FA/BRCA axis in the control of cell fate FANCE FANCD2 FANCG FANCF BRCA1 FANCM FANCL FANCA FANCC FANCB PMC5574030__F1 An overview of central carbon metabolism CAD HEL-S-162eP CS PMC7817765__F1 Activation pattern of NF-KB pathway in lung cell lines infected with SARS-CoV-2 JUN LTA AKT3 CD14 IRAK4 FOS RAC1 MAPK14 TLR3 NFKB1 IKBKB MAP2K1 BIRC2 PMC11914309__F9 Differentially expressed genes in TNF Signaling Pathway (rno04668) using transcriptomic data at 168 h after TMT administration JUN TRADD CHUK CYLD FADD PMC11914309__F7 Differentially expressed genes in Chemokine Signaling Pathway (rno04062) using transcriptomic data at 168 h after TMT administration BAD CRKL MAP2K1 GRB2 KRAS PMC4754913__F2 Diagram summarizing the reviewed mechanisms by which CCR9 induces different aspects of tumor chemoresistance PTEN MTOR CTNNB1 PMC5796186__F1 Malignant pleural mesothelioma disease progression FAT4 DCAF1 BAP1 CTNNB1 LATS1 CD44 CDKN2A LATS2 PORCN SUFU PTCH1 SMO NF2 GLI3 PMC8565650__F4 Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways RHEB TSC2 TSC1 PTEN IRS1 PMC10308129__F7 Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes HDAC1 INHBB ACVR1 KLF10 PTEN PMC8583909__F1 Effect of Epigallocatechin-3-Gallate on EGFR Signaling and Migration in Non-Small Cell Lung Cancer STAT3 EGF EGFR MTOR PMC6417506__F3 Chemical induction of proximity is sufficient for the regulation of diverse cellular processes DDB1 CUL4A TBP CRBN PMC10308129__F4 Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes HDAC1 SMAD1 DKFZp781O1323 SMAD2 PRDM16 UCP1 KLF10 FABP4 PMC4973703__F2 Main lipid classes and biochemical pathways involved in the production of TAG in developing seeds LPA PSD PC PMC5709591__F5 Interactome of negatively and positively changed genes comparing differentiated NIKS with differentiated NIKS16 cells MYB GNRH1 MAPK15 CTSS SOCS3 MAPK3 SERPINB3 MAPK14 ALB CDR2 NF1 SP3 MMP2 GAD2 CD163 NFKBIZ TIMP3 HHEX SLPI TNFRSF4 VEGFA BHLHB2 HRAS LOXL2 PARL IRF2 MAPK7 GPNMB CSK BCL2 TNFSF11 RNF20 FDFT1 BDNF TIMP1 TGFB1 GAS NFKB2 INS MERTK TGFBR2 OPRK1 TFRC BTK CCNO KLF16 HSF1 AHR GRM3 ASPN SFRS3 RERG IRF4 VHL SPRY2 RORC NR1C1 IL24 PTH KAT2B IL23A PMC10308129__F2 Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes JUN SIAH1 ITCH SMAD2 KLF10 PMC6060409__F2 Innate immune response to RSV: Advances in our understanding of critical viral and host factors STAT1 MAVS TLR4 IRF9 MYD88 PMC3432348__F1 Pathways activating and inhibiting complement C6 CD59 C7 HEL-S-62p C2 C9 C4B_2 CR1 PMC3899953__F6 A model for the role of ATP-mediated interaction between Rtg2 and Mks1 in ATP homeostasis MKS1 HEL60 HEL-S-26 PMC3263309__F1 Notch, Wnt, and Hedgehog signaling pathways regulate normal and stem cell fate CD44 MAML1 APC SMO MYC CTNNB1 PMC6627707__F1 Biogenesis of extracellular vesicles (EVs) carrying micro RNAs (miRNAs) in viral infection CD81 CD9 CD63 PMC2949777__F5 JAK/STAT pathway in infected EPCs STAT1 IFI6 STAT2 IRF9 PIAS1 IFI35 JAK1 PMC6701977__F3 Adenocarcinoma genotypes encode for transformation via the Ras pathway supported by the calcium pathway and the integrator complex MAPK14 RAD51AP1 CDKN1A CDKN1B HLA-DQA1 PRIM2 ITPR2 TNF HLA-DQB1 SOX5 PMC7527139__F1 Summary of metabolic networks in iFermCell215 MCC MAL CIT PMC9205143__F2 Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders CDH2 NTRK3 SOX4 PMC9205143__F4 Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders TMEM9B CDK14 PMC8533303__F6 Anticancer Targets and Signaling Pathways Activated by Britannin and Related Pseudoguaianolide Sesquiterpene Lactones MTOR MYC EIF4E PMC5191957__F2 Carcinogenic Effects of Oil Dispersants: a KEGG Pathway-based RNA-seq Study of Human Airway Epithelial Cells PIK3CA LAMC1 MYC TRAF6 ITGA2B ITGAV RB1 TRAF4 BCL2L1 ITGA2 RELA IKBKB LAMB3 NFKBIA COL4A2 ITGA6 CHUK REL LAMA3 BIRC3 PMC7313573__F1 Figures show the metabolism and role of biotin, cobalamin, and pyridoxine in various pathways TH DBH PMC8753429__F6 Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NFKB signaling pathway HMGB1 TLR4 MYD88 PMC9092887__F10 miR-23b-3p rescues cognition in Alzheimer’s disease by reducing tau phosphorylation and apoptosis via GSK-3B signaling pathways BAX BACE1 GSK3B ADAM10 PMC9503744__F1 Crosstalk between Ca2+ Signaling and Cancer Stemness: The Link to Cisplatin Resistance BAX CASP9 ATR CASP3 MDM2 PMC2745643__F1 Beta-catenin signaling and its regulation BCL9 APC CTNNB1 PMC11551840__F6 Proposed modes of mechanism of action of AZD5582 in OSCC CASP8 TRADD MLKL RNF31 TNF TRAF2 FADD PMC2939005__F1 Two major insulin signaling pathways TH GRB2 INS PMC12114876__F2 Medicinal Chemistry Strategies in Targeting TGFBR1 Kinase Domain: Unveiling Insights into Inhibitor Structure–Activity Relationship (SAR) TGFBR2 TGFBR1 PMC6925247__F7 TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2Alpha-ATF4 pathway NBR1 TIPRL ATF4 EIF2A PMC2898064__F10 Views of predicted functional interactions CD40 FAS TNFSF6 CRADD PMC3639655__F4 Schematic depiction of c-Myc functional interactions with other pathways (for full discussion, see section Induction–Reversion Tumorigenesis in Animal Models by Oncogene-Driven Cancer Network Formation) CDK6 CDK2 MDM2 MYC CDK4 PMC8026474__F2 Simplified overview of PRR signalling pathways in gastrointestinal epithelial cells TLR9 TLR5 TRAF6 MYD88 NLRP1 TLR1 NLRP6 TLR3 IL16 TLR4 NOD2 TIFA ALPK1 PMC5037548__F4 Apoptosis signaling pathways induced by icariin and icariside II BAX TRADD FADD PMC6677617__F4 Shh activates the PI3K/AKT and INSM1 signaling pathways to stabilize and prevent N-myc from entering the proteasomal degradation pathway INSM1 ASCL1 GSK3B SHH PMC8397734__F4 Sulfur energy metabolism and physiological interaction scheme of E. rectale and B. wadsworthia in the human gut SLA MUC2 DHPS PMC3533556__F7 IL-13–induced airway mucus production is attenuated by MAPK13 inhibition CLCA1 MUC5AC MAPK13 PMC5686390__F1 Mucosal-associated invariant T (MAIT) cell activation SAG MR1 APC LAG3 PMC2704469__F8 Scheme indicating expression of Tcf4 proteins and effects of Wnt–Beta-catenin signaling to inhibit the transition from premyelinating to mature oligodendrocyte PDGFRA APC OLIG2 TCF4 OLIG1 PMC8879721__F8 Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling CDH2 STAT3 CCND1 CDK4 PMC3233564__F3 Mammalian MAPK signaling pathways MAX MAF TRAF2 PMC6881749__F4 A proposed model of the impact of elevated levels of circulating IL-6 on skeletal muscle redox balance NQO1 HDAC2 PMC6431020__F5 Schematic diagram of molecular mechanisms underlying PA-induced GC metastasis FABP5 SP1 PMC3097097__F2 Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term IL17F IL17RC SP1 CCL7 CS JAK1 TRAF6 PMC10970955__F1 Systematic engineering for the de novo biosynthesis of genistein and glycosylated derivatives FAS PGM2 ACD PMC9046764__F6 Genomic signatures of artificial selection in the Pacific oyster, Crassostrea gigas CDC42 CASP9 MAP4K3 CASP8 EGFR SMAD2 SMAD4 ATF2 ITGB3 WNT2B DUSP3 FZD4 FST NOTUM BIRC2 CDK4 PMC8642467__F4 Mutations that switch genes from two-hit to one-hit drivers in six cancer types PIK3CA STK11 KEAP1 SMAD2 BRAF SMAD4 PTEN MTOR TSC2 NF1 NRAS ATM MDM2 NOTCH1 PMC8123811__F3 On Iron Metabolism and Its Regulation BMP6 SMAD1 TFR2 DKFZp781O1323 SMAD4 HAMP HFE HFE2 PMC8219471__F1 STING and liver disease CGAS IRF3 PMC9320502__F3 Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions NLRP3 MAF TRAF6 PMC2880289__F6 Complex deregulation of the Neuregulin/ERBB2 signaling pathway HSP90AB1 RPS6 BAD RAF1 ERBB4 PIK3R1 PTEN MTOR MYC HRAS GRB7 PRKCI EREG RPS6KB1 SOS2 ERRFI1 CDKN1B SI ERBB2 MAP2K1 GRB2 PMC3494627__F3 Cancer-suppressive inflammation TRAF6 IL1B MYD88 PMC7463798__F3 Proposed signaling pathways affected by SphK inhibitors SPHK2 tmp_locus_29 MTOR CTNNB1 PMC3728269__F1 Signaling pathways in melanoma.Notes: Oncoprotein Ras activates both the MAPK and PI3K/Akt survival pathways STAT3 BRAF PMC4772274__F2 Ingenuity pathway analysis of miR-221 and miR-483 target genes ADAM11 FGF14 SHANK2 PPP3R1 MYC DMRT3 STAT1 HIPK2 PBX3 PAIP2 ATE1 ZNF385A TIMP3 CPEB3 CRAT KSR1 KIT FOS FMR1 EIF4E NRG1 PAFAH1B1 SPRED1 BTG2 ATXN1 MAPK10 CACNB4 ADCY1 NFATC3 GRB2 PMC3910500__F6 Canonical PI3K and MAPK pathway activation determined by reverse phase protein arrays and compared between GBM subclasses: Proneural (P, purple, n=55) and Mesenchymal (M, red, n=45) TSC2 TSC1 IRS1 EIF4E PMC3199248__F1 TLR induction of inflammation by parasitic infection IRF3 IRF7 MYD88 PMC8985231__F8 Intercellular Communication in the Islet of Langerhans in Health and Disease PDE3B SSTR2 EPHA4 EPHA7 PMC5749594__F3B Association of the activity of metagene 19 with two distinct image phenotypes LRIG1 EGF PI3 EGFR KRAS PMC9653095__F3 NAD+ synthesis from the de novo, Preiss-Handler and Salvage pathways NAPRT HEL-S-90n PMC5749594__F3A Association of the activity of metagene 19 with two distinct image phenotypes LRIG1 EGF PI3 EGFR KRAS PMC9653095__F6 Graphic summary representation of tryptophan metabolism and disposition in cancer biology and proposed therapeutic strategies SLC3A2 KYNU SLC7A5 PMC3521040__F2 Molecular mechanisms of activation, amplification, regulation, and evasion of the AP C3 convertase SCIN FH HEL-S-62p CD46 CD55 VCP CP PMC11800460__F7 Graphical abstract image illustrating the mechanism of EPN3-mediated EGFR stability and its role in NSCLC development EGF EGFR EPN3 PMC3695632__F3 Case 19-2010: A 35-Year-Old Man with Adenocarcinoma of the Cecum BAD RICTOR EGFR MCL1 MDM2 GRB2 MTOR MYC CCND1 PMC8144931__F5 Next-generation sequencing analysis reveals that MTH-3, a novel curcuminoid derivative, suppresses the invasion of MDA-MB-231 triple-negative breast adenocarcinoma cells SYK BAD GAL RAF1 RBL2 PTEN CD19 RAC1 TSC2 FAR1 BCR MEI1 MDM2 PMC3891682__F2 Putative miRNAs for the diagnosis of dyslexia, dyspraxia, and specific language impairment EFNA5 EPHB4 GNAI3 EFNB2 DCC NTN1 PLXNA2 LIMK2 SEMA4F L1CAM PAK4 EFNA1 EPHA7 RAC1 SEMA3D SEMA6D ROCK1 SEMA6A PAK6 SEMA5A ABLIM1 PMC5606116__F2 Signaling pathways of IL-2 JAK3 MTOR PMC11837473__F1 Integrated stress response signaling pathway ELF2 ATF4 PMC11837473__F3 Integrated stress response in neurodegenerative disorders IFNG ATF4 TRIB3 HEL-S-44 PMC10884763__F3 Illustrative representation of molecular mechanisms of obesity-induced non-communicable diseases TSC2 TSC1 PTEN GRB2 PMC11837473__F2 Mitochondrial dysfunction and ISR: The activation of the integrated stress response (ISR) during mitochondrial dysfunction is triggered by various mechanisms DELE1 OMA1 ATF4 PMC8206782__F3 Cytokine Overproduction and Immune System Dysregulation in alloHSCT and COVID-19 Patients IFNG GSDMD ZBP1 MAK TLR4 TLR8 IRF3 IRF7 TLR7 MTOR ACE2 PMC10884763__F5 WATME-specific immunotherapy for obesity-induced coronary heart disease (CHD) PCSK9 NLRP3 TLR4 IRF3 PMC12164274__F5 Mapping of transcriptomic data to the nonsmall cell lung cancer pathway BAX CASP9 RARA HGF POLK tmp_locus_29 JAK3 FHIT PMC7476772__F2 Immune Response to SARS-CoV2 & pharmacodynamics of rheumatology medications STAT3 COX1 APC IL2 PMC4997642__F1 Canonical Wnt signaling pathway (reproduced with permission from) APC CTNNB1 PMC9587158__F1 Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD IMP3 STMN2 PMC6804710__F1 Canonical and non-canonical Wnt signalling pathways known or needed to be proven to participate in rat tooth germ development.,,,,,,,,,,,,,,,,,,,, SIAH1 ROCK2 APC SMAD4 ARHA CTNNB1 BAMBI RBX1 SOST INVS CER1 SKP1 NLK DAAM1 PMC9569894__F8 Transcriptome Analysis Reveals the Complex Regulatory Pathway of Background Color in Juvenile Plectropomus leopardus Skin Color Variation MC1R SOST DCT TYRP1 IRS1 CTNNB1 PMC3294429__F4 The NDT80 transcriptional induction pathway CDC2 PMC2804177__F9 The signaling pathways regulating osteoblast-like cells proliferation in response to OSS CDK6 CDK2 CDK4 PMC5658232__F1 PI3K/Akt/mTor pathway and effects of mTOR-inhibitors RHEB TSC2 TSC1 PDPK1 IRS1 PMC6335494__F7 Schematic model of intracellular signaling mechanisms regulating proteasome inhibitor-induced apoptosis by FLT3-ITD involving the STAT5/Pim axis and the mTORC1/eIF4F/Mcl-1 pathway BAX EIF4B MCL1 PMC4240309__F2 Smad-dependent and Smad-independent TGFB family signaling CDC42 ALK ARHA MTOR TRAF6 PMC7019324__F3 Pathways of macro-autophagy ATG10 ATG3 ATG12 ULK1 ATG14 ATG5 PMC7019324__F2 Extrinsic and intrinsic apoptotic pathway TRADD OMP FADD PMC6077207__F8 Schematic presentation elucidating proposed mechanisms that TLB protects PC12 cells against oxidative stress-induced injury SIRT3 KEAP1 PMC5223235__F3 Processing and presentation of MHC class I and II restricted antigens for CD8+ and CD4+ T cell recognition, respectively APC B2M PMC7019324__F7 Routes of the complement system with its inhibitors currently studied in kidney transplantation C7 C2 C1S C9 CS C4A C4B_2 PMC7019324__F6 Toll-like receptor 4 signalling TBK1 HMGB1 TIRAP TLR4 IRAK1 IRF3 TRAF6 MYD88 PMC11678759__F3 Signaling pathways of melatonin CAND2 ME1 MAPK6 PMC3470116__F6 Simplified schema of putative signaling pathways accountable for the differential responses of A549 (A) and SNB19 (B) cell lines to Hsp90 inhibition and IR CDC2 PTEN MDM2 CDK4 PMC3469673__F1 Activated CD47 is a proximate regulator of multiple cell survival and cell death pathways GC BNIP3 SRC CD47 PMC6454043__F1 Ceramide (Cer) synthesis pathways and their cellular compartmentalization BAX SMPD4 VPS35 PINK1 CERK LRRK2 TLR4 PLA2G6 MTOR SMPD2 PMC6969104__F9 MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer SOX2 PC EZH2 MYC CDK4 PMC9001082__F3 PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress SMAD2 MTOR NOX4 PMC6318317__F1 Wnt signaling pathways and the intervention targets of Wnt pathway inhibitors APC GSK3B LRP5 LRP6 ARHA RHO CTNNB1 PMC9001082__F4 PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress NOS2 KEAP1 AHR MTOR PMC2748726__F1 Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas CD40 ATR CDKN1A BPI PRDM1 CHEK1 IRF4 BCL6 PMC12069271__F5 Pathway diagram of the NF signaling pathway (available at https://www IL15 TRADD SELE MLKL LIF CXCL1 SOCS3 IL6 TRAF3 TNF FOS CXCL3 CASP3 TRAF2 CYLD TNLG7C FADD PMC6484783__F2 Histone chaperoning pathway: from ribosome to nucleosome NASP TLK1 CDAN1 HAT1 TLK2 SETDB1 IPO9 PMC12069271__F4 Pathway diagram of lipid and atherosclerosis (available at https://www STAT3 TH CASP9 BAD TIRAP VLDLR SELE MAL TANK CD14 TNF HDC NLRP3 TLR4 APOB ATF4 PROC SELP PMC4166933__F1 Multiple leptin signaling pathways STAT3 PDE3B SOCS3 GRB2 PMC2675987__F1 Calmodulin-dependent nuclear import and disease RAN SOX9 SRY PMC10979123__F7 Schematic diagram illustrates the multifaceted role of the redox-sensitive GSK3B in podocyte injury upon type 2 diabetic insult and the protective effect of targeting GSK3B NQO1 IL6 TNF IRS1 PMC3731217__F7 Cited1 Deficiency Suppresses Intestinal Tumorigenesis CITED1 APC CTNNB1 PMC4066587__F2 The stomatal signaling pathway RFWD2 BIN2 ERF BAK1 PMC7241242__F8 Metabolic pathway showing the reactions involved in drought stress response at day 13: Red and blue arrows represent active reactions in drought and control, respectively TCP1 HPR CS CIT PMC8413067__F1 The Wound Healing through Noncoding RNA Interplay and GSK-3B/NFKB Signaling Interaction CXCL12 BCL10 COX2 AGER IKBKB CXCR4 TNF PMC3564524__F10 Novel signaling pathways involved in apo(a)-mediated effects on vascular endothelial cells CD36 GSK3B PTEN RHO SRC CTNNB1 PMC3005738__F1 Metabolic pathway of tamoxifen CYP2B6 SULT1A1 CYP2C19 CYP2C9 NAT1 PMC4398509__F1 Working model for pathway for bacterial lipoic acid metabolism and its possible regulation CRP LIPA PMC3606489__F3 TGFB/BMP and the Wnt pathway SMAD4 CTNNB1 PMC6664756__F4 Predicted mechanisms of ELF1 regulation of doxorubicin-induced apoptosis IPO13 TFIP11 TMEM86B NABP2 BCL2 ATM BAK1 PMC8607587__F1 Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages RPE IGF1 DKK1 PMC4526153__F4 The Biophysics and Cell Biology of Lipid Droplets LPA DGAT1 DGAT2 PC PMC11312736__F7 Glycolysis/gluconeogenesis, pentose phosphate pathway, photosynthesis and sucrose and starch metabolism in zygotic embryos of Yucatan green dwarf and Mexican Pacific tall cultivars HEL-S-162eP PDC PMC10835843__F8 Expression heat map of related genes and metabolites in phenylpropane biosynthesis, ascorbic acid, succinic acid and glutamic acid metabolic pathway RP1 GLS OGDH HK2 MNT RP2 CS HEL-S-64p PMC11312736__F8 Saturated and unsaturated fatty acid metabolic pathways and mevalonate and isoprenoid biosynthesis at intermediate and mature stages of YGD and MPT zygotic embryos MCAT HMGCR ACAT2 MVD IDI1 PMC11542157__F2 Signaling pathways regulating CMA activity GFAP TFEB MTOR PMC4850081__F23 Central Metabolism probed by hyperpolarized 13C enriched precursors FH GLS tmp_locus_29 MAL PMC9258700__F4 Gynostemma pentaphyllum against non‐alcoholic fibre liver disease based on network pharmacology and molecular docking RHEB TSC2 BAD FAS GRB2 INS PMC9097439__F2 Regulatory role of short-chain fatty acids in inflammatory bowel disease NLRP3 TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC7904562__F5 Network of transcriptional NR1I3-mediated response elicited by pesticides (here shown: IMZ) in rat liver, as computed with Ingenuity Pathway Analysis software CYP2B6 EPHX1 APP GSTM5 CYP1A1 MED1 PMC11542157__F6 CMA dysfunction contributes to multiple diseases EGF NLRP3 EGFR PAX2 MCL1 PMC11542157__F5 CMA and neurodegenerative diseases NLRP3 TFEB MEF2D PMC4905058__F2 General overview of the class I PI3K signaling pathway RHEB TSC2 BAD BTK C2 ARHA GAB2 PMC4655250__F2 Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment ATF3 MC1R BRAF PTEN ATF4 MTOR PMC8935059__F9 Mitochondria Related Cell Death Modalities and Disease NFKB1 IKBKB RELA NFKBIA CA9 IKBKG PMC8924541__F4 Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) via Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats TG PCNA BCL2 TNF PMC8811214__F2 Cross-Talk Between EGFR and E-Cadherin STAT3 EGF EGR1 EGFR MMP2 ARHA MMP9 CTNNB1 PMC2911128__F1 PI3K/Akt/mTOR signaling pathway RHEB BAD MDM2 MTOR DEPTOR EIF4E PMC6895153__F5 Hormone-related pathways enriched in DEGs of the brain and gonads PRLR TPM1 STAR CYP17A1 TSHR CYP11A1 PRL FSHR GHR LHCGR PMC6406801__F6 Kinetochore PP2A-B56 and PP1 promote the stability of microtubule attachments and efficient Spindle Assembly Checkpoint silencing in animal cells CDC2 SPC25 KNL1 NUF2 KNTC2 SPC24 PLK1 PMC5356307__F7 Model describing the effect of a synergy between extracellular TGFB1 and Hsp90B on downstream signalling in colon cancer cells FAS TGFB1 SMAD4 PMC3911027__F4 Metabolic potential of Acidilobus-like populations from YNP deduced from coding sequences obtained from metagenome assemblies POR MAL PDC HBD FADD PMC2384123__F8 Possible model for CCL5-mediated mRNA translation in CD4+ T cells EIF4B CCR5 CCL5 MTOR CCND1 EIF4E PMC3520613__F5 Macrophage VLDL Receptor Promotes PAFAH Secretion in Mother’s Milk and Suppresses Systemic Inflammation in Nursing Neonates VLDLR PLA2G7 PMC8242269__F10 Large-scale Proteomic and Phosphoproteomic Analyses of Maize Seedling Leaves During De-etiolation RPE HEL-S-162eP PC PMC11775980__F2 Lipid Pathways Located at MAM ACAT1 SPTLC2 STAR PSD SCD PBR SPTLC1 PMC8391210__F3 Follistatin-Like Proteins: Structure, Functions and Biomedical Importance FOXO1 MVP SMAD2 MTOR TNF PMC7602614__F3 STAT3 regulates the transcription of gene sets involved in cancer development STAT3 HGF SOX2 VEGFA ABCC6 ABCC2 TWIST1 PMC7602614__F2 JAK/STAT signaling drives the differentiation of T helper cells (Tregs) STAT3 STAT1 STAT4 FOXP3 IL1B GATA3 PMC5881442__F1 Mechanisms for visual chromophore production in the retina relevant to cone pigment regeneration RPE F2 RPE65 PMC3605242__F6 Ingenuity Pathway Analysis visualization of oncogene interactions STAT3 JUND APPL1 SHC1 JAK3 SMAD2 TLR9 IRAK1 PTPRC PELI1 FLNA MYD88 RB1 PELP1 CD24 PPP2R2B SP3 MDM2 DCN SMARCA4 RAD51 AXL PLAUR ITGB3 FOS TP53BP1 ERBB3 BRCA1 PLEC SNCG CDKN1B TNFSF11 DACH1 MAP3K5 GRB2 CXCR4 SNAP23 PPM1D ATR HCLS1 TNFAIP3 CD36 EGFR PML PPP2CA NEDD9 IKBKG PROX1 BTK CSF2RB ADAM17 CDK7 INSR MED14 CHEK2 ATM CCND1 CEBPB YWHAG DBF4 CDC2 HEL-S-72p JUN HEL-S-67p MYO6 KIT TLR5 PPP2R1A CBL IL2RB ITGB1 CASP3 ERBB2 LYN KAT2B FADD PMC9026097__F9 Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes HMOX1 CASP4 MAF IRF1 IL6 CXCL8 PMC6962519__F3 Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1)-independent regulation of protein translation RHEB TSC2 EEF2 MTOR DEPTOR PMC4051995__F2 Mammary Development and Breast Cancer: The Role of Stem Cells NOTCH2 NOTCH3 NOTCH1 PMC11394644__F1 NAD+ biosynthesis pathways NNMT NAPRT HEL-S-90n KY KYNU HAAO NAMPT AFMID PMC11394644__F3 Summary reaction schemes depicting the influence NAD+ biosynthesis pathway reactions on the tumor microenvironment (TME) NNMT NAPRT PARP16 NAMPT NMNAT2 PMC11394644__F2 Reaction schemes for NAD+-consuming enzymes SIRT3 NNMT SIRT4 SIRT2 SIRT1 SIRT6 PMC6856900__F4 Gene expression profiles of the PI3K-AKT signaling pathway in treated HepG2 cell MYB PIK3CA RAF1 SOS1 MCL1 CRTC2 MYC PRKAA1 RPS8 BCL2L1 ANGPT1 PRKCA HEL-S-1 MDM2 TNFSF6 IRS1 EIF4E HRAS PCK2 RHEB TSC2 TSC1 RXRA CDK2 BCL2 GRB2 BAD STK11 PTEN PPP2CA MTOR CSF3 CSF3R TLR4 PHLPP2 MTCP1 CHUK ATF4 CCND1 RPTOR EIF4B SGK1 EIF4EBP1 RBL2 LPAR1 BCL2L11 RAC1 MAGI1 GYS1 NFKB1 MAP2K1 PMC12084782__F7 Graphical abstract of this work SMAD2 SMAD4 DCN PMC8989389__F1 Malignant glioma subset from actuate 1801: Phase I/II study of 9-ING-41, GSK-3B inhibitor, monotherapy or combined with chemotherapy for refractory malignancies GSK3B BCL2 PMC8940245__F3 Akt: A Potential Drug Target for Metabolic Syndrome TG BOC FOXO1 RAC1 IRS1 PMC11754404__F7 The effect of Formononetin (FMN) on porcine oocyte in vitro maturation and early embryo in vitro CD44 CCS KEAP1 PTGS1 PTGS2 PMC8597313__F2 New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis CGAS PKN1 PINK1 VAPB INA ND6 CASP3 ND3 NEFL STMN2 OPTN NEFH PMC10299206__F2 TGFB signaling pathway TRAF4 JUN SMAD2 SMAD6 SMAD4 RHO MTOR DROSHA PMC10299206__F3 Relationship between genes related to TGFB signaling pathway and pathogenesis of oral cancers TXN TGFBI SMAD2 SMAD4 ARG1 TRAF6 MYC CDK4 RUNX3 PMC3601079__F3 Maslinic Acid-Enriched Diet Decreases Intestinal Tumorigenesis in ApcMin/+ Mice through Transcriptomic and Metabolomic Reprogramming BAX CASP9 JUN DCC BAD SMAD2 APC GSK3B SMAD4 FOS TGFBR1 CTNNB1 CASP3 PMC5706558__F1 Strategy for analysis of ERBB2-driven gastric cancer EGFR ERBB2 GRB2 MYC SET PMC10384322__F2 Free Radical and Viral Infection: A Review from the Perspective of Ferroptosis TF ROS1 LPO GPX4 TLR4 PMC5006950__F1 PD and PK pathways of HMGCo A reductase inhibitors (Statins) HMGCR PMC5706558__F8 Summation of the proteomic values for the ERBB2− sample set for genes present in the regulation of actin cytoskeleton pathway for ERBB2− set from KEGG HEL114 CR1L PXN F2 APC RHO INS DOCK1 PMC2727866__F1 EGFR-dependent MAPK activation LPA HBEGF EGFR IGF1R PMC5706558__F7 ERBB signaling pathway analysis TGFA HEL-S-11 SHE PMC4733034__F2 Assay for defining the immunostimulatory potential of different RNAs IRF9 IRF3 IRF7 PMC9637655__F1 Dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology OGA XBP1 PMC5750051__F3 Proposed pathway for B12 targeting to methionine synthase for MeCbl synthesis MMACHC MMADHC PMC7600793__F6 Scheme of N9 microglia NF-kB, NFAT, MAPK, and IL-10/STAT3 inflammatory pathways modulated by 2J19 GIB fraction CD40 STAT3 JAK1 PMC3406917__F3 Schematic Diagram of Matrix Protein Import into Peroxisomes.Cytosolic PEX5 and PEX7 recognize their cargo proteins (square and round shapes) via binding of specific targeting sequences, PTS1 and PTS2, respectively PEX7 PEX6 PEX5 PMC9637655__F3 Dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology OGG1 ALDH2 REST CD36 SNAP29 SMAD2 MTOR XBP1 NOX4 PMC5112273__F2 How autism-risk genes regulate neuronal structure and their sites of action NCAM2 MYO16 DLGAP2 DYRK1A CTTNBP2 PTEN MTOR ADNP STXBP5 SHANK3 SYNGAP1 ELMO1 BDNF PMC5736463__F7 RUNX2-I is an early regulator of epithelial-mesenchymal cell transition in the chick embryo POSTN SNAI2 SNAI1 ZEB2 TWIST1 PMC5406241__F1 Schematic illustrating our strategy to generate iPSCs resistant to IL-1-mediated signaling for tissue engineering applications MAP3K7IP1 TRADD UNK MYD88 PMC3959765__F3 RANKL-perturbed network and master regulators MAX CDC42 AURKA PPARG SYK VEGFC HEL113 TIMP1 TGFB1 ENO2 AKT3 NRP1 FHL2 HIF1A TCF4 TRAF3 MYC TRAF6 MAP3K14 MAPK14 TGFBR2 INHBA SOX9 KLF10 GATA6 SRC CDH2 CAV2 SOX2 VEGFA IL6 PAX6 ID1 VCAN CBL ITGB1 HOXA13 MEN1 RELA MAP3K7 POU2F1 WNT3 FOXA2 TWIST1 GAB2 PMC4189458__F2 Progesterone functions via intrinsic (mitochondria-centered) and extrinsic (cell membrane-mediated) pathway of apoptosis FAS DIABLO FADD PMC4459083__F1 Scheme for producing fatty acid-derived biofuels in yeast FAS PDC PAH PMC3475164__F1 Biosynthesis of glycerophospholipids PSD PEMT HEL-S-5 PC PAH PMC7798998__F2 Innate immune signaling pathways sensing SARS-CoV-2 CGAS MAVS TLR3 TLR8 TLR7 MYD88 PMC1564158__F2 Predicting Essential Components of Signal Transduction Networks: A Dynamic Model of Guard Cell Abscisic Acid Signaling GC HEL-S-84 PC RAC1 PMC2709272__F1 Wnt/Beta-catenin signaling in adipogenesis and metabolism WNT10B WNT5B SFRP5 DKK1 GSK3B TNF PMC7989008__F5 Re-analysis of 29 selected genes by KEGG pathway enrichment RFWD2 CASP9 ATR CD2 PERP PTEN CDK6 PRH2 SIVA1 CASP3 FES ATM APP PIGS PMC10377129__F9 Active Estrogen–Succinate Metabolism Promotes Heme Accumulation and Increases the Proliferative and Invasive Potential of Endometrial Cancer Cells SLC25A38 SDHB ALAS1 NCOA1 PMC9500712__F8 Molecular Mechanisms of Cassia fistula against Epithelial Ovarian Cancer Using Network Pharmacology and Molecular Docking Approaches ACLY AURKA PIK3CA NR1H2 PGR TERT TYMS MPO CTNNB1 ALB INSR F2R NR3A2 F10 IL18 MMP2 MMP3 KDR TOP2A ABCB1 CCR1 CDC2 CYP17A1 PTPN11 KIT PTGS2 MMP9 TNF SHE STS PDC RELA FBP1 CDK2 BCL2 PRSS1 CA9 PMC7258299__F3 Metabolic pathways that produce and interconvert acyl-CoAs involved in histone acylations ACLY ACSS2 GCDH PDC CDYL PMC7510089__F5 Key genes analysis in the AD STAT3 PPARG VEGFC CXCL12 EPHA2 PIK3R1 PTEN MYC CXCL8 NGF ANGPT1 PDGFC PRKCA CCND1 CDC2 PDGFD JUN PARG KIT VEGFA IL6 ANGPT2 KITLG FGF2 CD44 FGF7 ADCY3 RAPGEF1 PMC8290582__F3 Alpha- and Beta-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease JUN BAD RAF1 SMAD2 TGFBR3 SMAD4 GRB2 FOS PMC7510089__F4 Key gene analysis in the OS AURKA STAT3 PPARG VEGFC CXCL12 ALPL GABARAPL1 EGFR PIK3R1 PLK4 TYMS FOXM1 ACTA2 GADD45B MMP2 CCNB1 POLR2A JUN EGR1 SGK1 IL6 IRS1 FGF2 CD44 CEBPA RHOB APOB BDNF GADD45A BCL6 PMC7500440__F1 Pro-tumour activities of neutrophils.a) Neutrophils can express ligands of immune checkpoints expressed on T cells, such as PD-L1 EGF CXCR1 ARG1 MMP9 IL8RB IRS1 PMC6770430__F2 Hyperglycemia associated metabolic reprogramming in cancer cells and potential targets TG HEL-S-162eP TIGAR HEL-S-30 PMC8313570__F1 Regulatory pathways of ferroptosis POR GLS GPX4 HEL-S-64p PMC5835589__F1 Targeting DDR vulnerabilities of SCLC RB1 ATR WEE1 CDK2 ATM MYC CDC25B PMC545806__F7 Different pathways use the RecQ helicase in response to replication stalling MRC1 RAD51 PMC9099610__F2 Poultry Meat and Eggs as an Alternative Source of n-3 Long-Chain Polyunsaturated Fatty Acids for Human Nutrition ELOVL2 GLA ELOVL5 PMC6763782__F3 Regulation of the main phases of the autophagic pathway by the C2‐WW‐HECT E3s ATG101 WWP1 UBC ULK1 UVRAG PMC10253478__F1 Action of probiotics MUC13 IL4 CORT MUC6 MUC5B MUC2 GC IL2 MUC1 FOXP3 MUC4 BDNF TLR10 PMC4404113__F5 Unigenes involved in the three metabolic pathways AIDA GDA PMC8008218__F6 Study findings CDH2 PMC9561884__F4 Roles and targeting options of TRIM family proteins in tumor CDK19 TRIM44 TRIM46 CACTIN KY WAS TRIM67 TRIM52 KIN PMC5614325__F2 SASP regulation BRD4 ATM MTOR NOTCH1 PMC9561884__F5 Roles and targeting options of TRIM family proteins in tumor TRIM31 TRIM44 STAT3 TRIM32 TRIM47 GSK3B TRIM11 TRIM66 TRIM45 TRIM59 MTOR CTNNB1 PMC4771746__F2 Example pathway (Alzheimer's disease) overlaid with gene expression data from BBB cell line LPL IDE CASP9 BAD FAS CASP8 CYCS APOE GSK3B BACE1 TNF ATP2A1 ERN1 SDHA RYR3 MME HEL-S-162eP CASP3 APP ADAM10 APAF1 IL1B FADD PMC11808201__F2 Mass Spectrometry as a First-Line Diagnostic Aid for Congenital Disorders of Glycosylation COG5 VMA21 GMPPB SLC35C1 DDOST MAN1B1 GANAB DPM3 ATP6AP2 PRKCSH SLC35A2 MGAT2 STT3A ST3GAL3 B4GALT1 DPM2 TUSC3 RFT1 ALG3 FCSK NUS1 SLC35A1 COG3 ALG5 SRD5A3 MAGT1 SLC35A3 DOLK VMA12 ALG6 ATP6V0A2 ALG10 TRAPPC11 DHDDS SLC39A8 ALG13 DPM1 COG8 TMEM165 COG7 SSR4 COG2 SSR3 COG1 VMA22 STT3B COG6 OSTC PMC12212355__F2 Preventing T cell exhaustion and enhancing cytotoxicity through metabolic reprogramming ZAP70 IL10 BATF RASA2 ADRB2 HEL-S-11 SIRT1 GNLY PMC2043390__F9 Biphasic expression and up-regulation of HWP1 at the bud-hypha transition CDC42 NRG1 CAP1 PMC6037732__F8 Cell cycle arrest and apoptosis of hepatocytes CCNE1 PPP2R5C CCND1 PMC3059259__F2 Autophagy, inflammation and neurodegenerative disease IFNG TNF IL1B PMC3367549__F4 BMP signaling pathway and regulation of SMAD activity SMAD1 DKFZp781O1323 SMAD6 SMAD4 PMC3367549__F3 Sonic hedgehog (SHH) signaling pathway KIF7 BOC SUFU NKX2-2 PTCH1 SHH SMO RAB23 GAS1 PAX6 GLI3 PMC8576332__F7 Suppression of EGFR/PKCD/NFKB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer EGF FAS EGFR MMP9 FADD PMC5770391__F4 Changes in brain energy metabolism during worker maturation elucidated by pathway analysis of data from brain RNA-seq experiments ACLY DLAT FH OGDH PC CS PMC7885061__F2 Altered gene expression profiles and signaling pathways in vitiligo PTPN22 RPS6KB1 USF1 PDC DCT BCL2 TYRP1 FOXP3 TNF PMC8211512__F2 Mitochondrial Quality Control in Cardiac Ischemia/Reperfusion Injury TFAM MFN2 BNIP3 PMC3864900__F6 Ubiquitylation in immune defence and pathogen evasion BCL10 ITCH TRAF6 PMC3428099__F1 FAM83A and FAM83B: candidate oncogenes and TKI resistance mediators EGF BAD FAM83B FAM83A EGFR MCL1 BRAF GRB2 MTOR MYC PMC3864900__F3 Ubiquitylation in immune defence and pathogen evasion TBK1 TRIM56 TRIM25 MIB1 MIB2 NOD2 TANK IRF3 TRIM23 PMC9018712__F10 Compound mutant phenotypes of Vangl2, Grhl3, Usp39, and Ube1 genes during mouse development and schematic model of USP39/GRHL3 complex in the de-ubiquitination pathway GRHL3 PMC5562757__F9 Mechanistic model for ATF3-mediated negative regulation of antiviral and autophagy pathways in the absence of type I IFN ATF3 STAT1 STAT2 IRF9 ISG15 ATG5 PMC8888345__F2 Adaptive chromatin remodeling and transcriptional changes of the functional kinome in tumor cells in response to targeted kinase inhibition CDK19 RHEB FOXA1 TSC2 DDR1 CDKL5 TSC1 FRK EGFR MTOR SRC MYC PMC3367549__F2 Canonical (left) and noncanonical (right) WNT signaling pathways JUN GSK3B LRP5 LRP6 RHO FOS DAAM1 CTNNB1 PMC3367549__F1 FGF signaling cascades, an example of RTK signaling CDC42 ETV5 JUN BAD RAF1 FRS2 ETV4 RHO GRB2 FOS PMC11202107__F1 Suppressor of Cytokine Signaling Proteins 3 and 5 Potentially Delineate Polarization of Th cells in Chronic Rhinosinusitis STAT3 JAK3 SOCS5 STAT4 SOCS3 IL6 JAK1 TYK2 GATA3 PMC7409382__F1 S1PRs signaling regulating endothelial barrier function SPNS2 S1PR3 S1PR2 SPHK1 RHO RAC1 PMC2983445__F3 Growth factor signaling pathways mediating survival in multipotential stromal cells EGF BAD HGF FOXO1 EGFR BCL2 PMC2983445__F2 Growth factor signaling pathways mediating proliferation in multipotential stromal cells EGF HGF WNT3A EGFR SMAD2 APC BMP2 SMAD4 CCND1 CTNNB1 PMC6273666__F6 The possible inhibitory mechanism of ethyl acetate fraction of M COX2 TLR4 IL6 IL1B PMC9502517__F2 Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach FAS CASP8 CASP3 FADD PMC8591777__F5 Application of Lipidomics for Assessing Tissue Lipid Profiles of Patients With Squamous Cell Carcinoma EN2 PC EN1 IMPACT PMC3467044__F9 Model depicting the molecular underpinnings of lamin B2 origin licensing ME3 TET2 CDC6 CDT1 MYC ORC2 TDG PMC3678724__F1 Alterations of the AKT pathway in human cancer RHEB PHF20 TSC2 BAD TSC1 NF1 PTEN MDM2 CCND1 VHL EIF4E PMC6056347__F3 The complex interplay between ER stress and liver damage and transformation(1) Unremediable ER stress in hepatocytes can elicit cell death, which might proceed through apoptotic, necrotic, or pyroptotic pathways or a combination thereof NLRP3 IL16 CASP3 PMC10556370__F3 Mechanisms underlying TAX-mediated neuroprotection against AD or CAA APOE BACE1 APP SIRT1 PMC6716635__F3 Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance NR1i1 RAF1 KCNJ5 HEY2 ATP2A2 FOXM1 ALDH2 MYL3 THBS4 CTGF KCNJ2 NPPB RCAN1 ACE2 BCL6 NPRC PMC3292500__F3 Top scored pathway map affected by BaP "Apoptosis and survival_Endoplasmic reticulum stress response" BAX EIF2S1 ATF4 PMC4732899__F6 Epidermal growth factor receptor signaling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease EGFR APC IL4 IL17A AREG PMC9320762__F4 Non-Canonical Programmed Cell Death in Colon Cancer RIPK3 TLR3 MLKL TLR4 RIPK1 FADD PMC9320762__F2 Non-Canonical Programmed Cell Death in Colon Cancer TF IREB2 TFRC GPX4 FACL4 PMC9320762__F1 Non-Canonical Programmed Cell Death in Colon Cancer CDC2 ATR CDK2 ATM SSB PMC11011199__F2 Prediction of Response to Anti-Angiogenic Treatment for Advanced Colorectal Cancer Patients: From Biological Factors to Functional Imaging BAD RAF1 PTEN GRB2 SRC PMC5626732__F8 Signalling disruptions in Depdc5 FS/FS mice TSC2 TSC1 NPRL2 C16orf35 DEPDC5 IRS1 PMC2700035__F6 Load-driven signaling pathways predicted with ankle loading at 1 h after the last loading RB1 GK3 FST APC CER1 SMAD4 ARHA CHAD PROC CD47 SKA1 CTNNB1 PMC6295338__F3 TPS EGF Response Pathway Model EGF EPHA2 SHC1 EGFR WASL MAPK9 ATXN2 MAPK3 ERF PLCG1 MHC2TA PRPSAP1 TXN2 CSNK2A1 SPRY1 MAPK1 TUBA1A PTPN18 TOM1L1 CRKL PAG1 IRS4 ATP1A1 BCLAF1 RNF213 HGS CBL RUNX1 c-fgr PAK1 CD2AP EPN1 ARHGEF7 DOCK4 INPPL1 MAP2K1 GRB2 WIPF2 AKAP12 PS1TP5BP1 PMC3442837__F1 Regulation of phenotypic transitions in the fungal pathogen Candida albicans CDC42 NRG1 TPK1 PMC1852792__F6 A hypothetical model for association of four subcomplexes in the FA core complex FAAP24 UBE2T PMC3169732__F6 Schematic diagram illustrating the proposed signaling pathway involved in cigarette smoke extract-induced increase in expressions of inflammatory genes in airway smooth muscle cells TLR4 TRAF6 MYD88 PMC5627668__F1 N-Arachidonoyl Dopamine: A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities TH TRPV1 FAAH PMC8810792__F7 Transcriptome of human neuroblastoma SH-SY5Y cells in response to 2B protein of enterovirus-A71 PLAT TNFRSF9 RELB PTGES CCL2 TNF BIRC3 PMC8822417__F8 Activation of PPARG in bladder cancer via introduction of the long arm of human chromosome 9 FOXA1 PPARG PTEN GATA3 PMC12199311__F7 Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling STAT3 HES7 CCND1 PMC6761106__F2 Suggestive model for receptor-mediated pathway involved in CD biology FAT10 ABCF1 MOG TLR4 SMO TRAF6 TNF MYD88 PMC7801250__F3 Synopsis of lysine monomethylation events involved in photosynthesis and carbon metabolism in SynechocystisA SDHB CYB FES CP PMC6226306__F1 New Therapies in Head and Neck Cancer STAT3 EGFR MTOR PMC8076159__F6 Novel circGFRA1 Promotes Self-Renewal of Female Germline Stem Cells Mediated by m6A Writer METTL14 METTL14 GFRAL PMC7063815__F1 Relationship between mTOR and tumors RHEB RNF168 H2AX OTUD7B PTEN MTOR DEPTOR TRAF2 PMC8994166__F5 Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation OPA1 MFN1 MFN2 PMC7876650__F2 Contrast effects of autophagy in the treatment of bladder cancer ATG101 RHEB TSC2 TSC1 ULK1 TFEB ZKSCAN3 ULK2 PMC4601263__F5 CLN3 and sphingolipid signaling pathway interactions analyzed using Pathway Studio CERS2 DEGS2 SMPD1 CLN3 UGT8 CERS6 PMC9354743__F2 RNA m6A modification orchestrates the rhythm of immune cell development from hematopoietic stem cells to T and B cells TH METTL14 YTHDF2 METTL3 PREB PMC7758733__F7 Proposed signal transduction pathways by which quercetin induces apoptosis in AML cells BAX IGF1 BCL2 MTOR PMC6838415__F8 Gut microbiota from colorectal cancer patients enhanced the progression of intestinal adenoma in Apcmin/+ mice NLRP3 APC IL1B CTNNB1 PMC7437582__F1 New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target? APC PTK7 RYK CTNNB1 PMC5039377__F4 DNA-damage response pathway-network XPA DDB2 ATR MSH2 PCNA NBN ATM UNG ATF1 MYC RPA1 XPC PMC8847669__F1 Multi-Level Computational Modeling of Anti-Cancer Dendritic Cell Vaccination Utilized to Select Molecular Targets for Therapy Optimization CD40 TNLG8A CXCL8 TRAF2 PMC11619685__F4 Activation of the p38 MAPK-mediated senescence pathway can occur because of pH changes or stimulation of ASIC1 or ASIC3, which initiates the ATM/ATR pathway ATR CDK6 ACCN3 CDK2 ATM MTOR SIRT1 CDK4 PMC8009543__F1 NLRP3 activation MAVS NLRP3 TXNIP MFN2 IL1B MYD88 PMC5650369__F8 Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages STAT3 JAK1 ATG5 PMC3169577__F1 Evolution of the TGFB Signaling Pathway and Its Potential Role in the Ctenophore, Mnemiopsis leidyi SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC8603464__F1 Regulatory role of the transforming growth factorB signaling pathway in the drug resistance of gastrointestinal cancers CDH2 SNAI2 CD24 SMAD2 MSC SMAD4 CXCR4 PMC11619685__F2 Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration GSDMD NLRP3 DFNA5 PMC10669584__F1 APE1/Ref-1 role in inflammatory bowel disease and the potential of redox signaling inhibition TF STAT3 TLR4 PMC11619685__F1 Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration BAX BAD BCL2A1 TNF FADD PMC7167255__F7 STYX/FBXW7 axis participates in the development of endometrial cancer cell via Notch–mTOR signaling pathway STYX BAX FBXW7 MTOR PMC2819730__F1 Urine-based assays for the detection of bladder cancer F11R LRP8 HHIP CYP20A1 SPHK1 LEPR APOE BMP7 TGFBR1 GNB1 ATF3 TFRC FKBP1A ERBB2 FLT1 AMFR CTNNA1 PMC9456256__F2 Metabolic and Cellular Compartments of Acetyl-CoA in the Healthy and Diseased Brain ACLY FAS CIC ChAT CS PMC2948663__F1 Molecular and genetic events in mammalian sex determination and differentiation CBX2 PBX1 DHH NR5A1 RSPO1 DMRT1 LHX9 WT1 EMX2 FOXL2 SOX9 SRY FGF9 WNT4 AMH GATA4 PMC2675653__F1 CART analysis of NER pathway and esophageal cancer risk ERCC1 XPA PMC6952788__F6 Cartoon illustrating the role of RAC1B in negative regulation of the epithelial-mesenchymal transition (EMT) program in (pancreatic) epithelial cells TGFB1 SNAI1 PMC4389820__F1 Major interconnected signaling pathways that regulate EMT CDH2 HEL-S-28 SMO ARHA TRAF6 CTNNB1 PMC3458820__F8 Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the Absence of Increased 25-Hydroxyvitamin D3 Levels in Male Mice CYP2R1 CYP27B1 CYP24A1 PMC4926486__F12 Mechanism of cell death in murine lung epithelial cells after repeated cycles of hyperoxia, radiation, and double-hit combination challenge BAX CASP3 BCL2 PMC8895238__F1 Hypoxia in the Interferon Response ADAR TBK1 CGAS MAVS STAT2 IRF9 IRF3 IFI16 IRF7 STAT1 TLR3 IFNAR2 IFNAR1 DDX41 JAK1 TYK2 PMC6672053__F4 Cellular response to T–R conflicts FANCD2 ATR BRCA1 BRCA2 FANCM PMC3572003__F1 Altered energy metabolism in cancer HEL-S-133P PTEN MYC PMC8754411__F8 Schematic drawing showing that MSC-exo eye drops alleviate GVHD-associated dry eye disease by reprogramming M1 macrophages to M2 via miR-204–mediated targeting of IL-6R/Stat3 pathway STAT3 CD81 CD9 ARG1 CD63 PMC8841219__F2 The renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19) PRCP ACE2 PMC9035226__F6 Summary & conceptualized pathway CDC2 RHOU SMURF1 CXCL1 RUNX2 CCND1 ID1 PMC1538848__F3 Expression data analysis and visualization on the PANTHER website IDE FER LAT PMC7577645__F2 TNFA and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis NOXA1 TRADD TNF EEA1 TRAF2 RAC1 PMC6591147__F3 Mechanisms promoting regulatory T cell (Treg) development and immunosuppression in the tumor microenvironment CCL22 SMAD4 CDK2 CCR4 FOXP3 PMC7885861__F1 Expression and function of the insulin/insulin-like growth factor system in glioblastoma cells STAT3 INSR EGFR HEL-S-28 IGFBP2 PTEN MTOR IRS1 PMC6444363__F6 Tat promotes astrogliogenesis over neurogenesis through its binding to Notch to activate the Notch signaling pathway HES1 RBPJ HES5 PMC12211004__F7 Schematic diagram regarding key parts of this study OSM OSMR PMC7138577__F7 Proposed model of the combinatorial effect of DDP and melatonin on NPC cells CD44 SOX9 CCND2 APC GSK3B WNT1 CTNNB1 PMC9496650__F2 Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways APC GSK3B AXIN1 CTNNB1 PMC10987652__F7 GSK3B inhibition inhibits microtubule dynamics TTL MAP1B SVBP VASH1 PMC10239817__F1 Peptides in reversing chemoresistance of breast cancer: current facts and future prospects SNCG ERBB2 PMC2772826__F1 Apoptosis in animal models of virus-induced disease BAX DIABLO FADD PMC7722149__F1 Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? MAPK1 MTOR PMC10375937__F13 Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway TLR4 TRAF6 IRAK4 MYD88 PMC11890417__F8 The role of LINC01305 and LAD1 in ESCC CDH2 LAD1 PMC3606520__F6 Summary of the putative biosynthetic pathway of non-arthro and arthro-series neutral GSLs in the cyst of the brine shrimp ICOS CER1 PMC3155178__F1 Synthesis of Dihydrotestosterone via the Classic and Alternative (Backdoor) PathwaysThe classic pathway of steroidogenesis leading to dihydrotestosterone is shown on the left, and the alternative pathway is shown on the right POR HSD3B2 HSD17B3 CYP17A1 CYP11A1 HSD17B2 AKR1C2 PMC2546909__F1 Signal transduction pathway elicited by Env interaction with CCR5 required for Rac-1 activation and membrane fusion TG TIAM1 CCR5 PMC10887283__F2 Therapeutic potential of anti-IL-1 agents in hidradenitis suppurativa CD80 CXCL1 IRAK1 CXCL2 IL36A IRAK2 IL1A IL36B CXCL8 IRAK4 MYD88 CD83 IL1R1 CCL20 IL1B PMC5564228__F2 Genomics, Biology, and Human Illness: Advances in the Monogenic Autoinflammatory Diseases TBK1 STAT1 CGAS STAT2 IRF9 IRF3 JAK1 TYK2 PMC7727076__F6 p53 signal pathway and cell cycle pathway regulated by CDK1 and CCNA2 in pancreatic adenocarcinoma (PAAD) DBF4 RFWD2 CASP9 ATR SIAH1 PCNA AIFM2 PERP PTEN MYT1 SKP2 TSC2 FER CDR2 CASP3 CDK2 WAPAL ATM MDM2 CDK4 CA14 PMC3540985__F1 CYTOKINES, INFLAMMATION AND COLON CANCER TLR4 RELA TRAF6 MYD88 PMC10375937__F14 Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway TLR4 TRAF6 IRAK4 MYD88 PMC8023278__F10 Estrogen signaling pathway ranked first in Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment terms TFF1 TGFA HEL-S-130P PGR EBAG9 HEL-S-11 GRB2 KRT19 PMC8079281__F8 TGF-Beta-induced cell motility requires downregulation of ARHGAPs to sustain Rac1 activity ARHGAP22 VAV2 VAV1 RAC1 ARHGAP24 PMC8023278__F11 Osteoclast differentiation signaling pathway ranked twenty-first in Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment terms SOCS1 SYK TGFA IRF9 SIRPB1 OSCAR CTSK FHL2 SOCS2 TREM2 BTK MAP3K7IP1 FRY GRB2 SRC CYLD PMC6289038__F2 Protein–protein network and pathway analysis PIK3CA MCL1 PIK3CD CYCS PLA2G1B SDC4 BBC3 HIF1A PMAIP1 MYC CTSG MAPK8 EGLN3 MAPK3 PLA2G2A MAPK14 ALB AHSG EGLN1 BCL2L1 ALOX5 PRKCA PTGS1 MMP2 NRAS A2M ALOX12 STX1A SRC APAF1 DCN CDH2 MAPK1 TIMP3 APOE PLG IL10RA VEGFA TNF FOS HRAS ACAN RICTOR IGF1 SUFU DFFA BCL2 PICK1 DIABLO IL10RB TIMP1 BRAF PTEN MTOR MPO HIF1AN IL2 APP BIRC3 BAX IL10 JUN PLD2 EIF4EBP1 IL4 MMP9 hEMMPRIN PTGS2 IL6 ARHA SDC1 BCL2L11 EGLN2 RAC1 VHL CD44 PTGIS FOXO3A NFKB1 RELA CASP3 PTGES3 CREBBP PTGES JAK1 TNFSF10 BIRC2 PMC9405677__F18 Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease SYN2 GRIA3 VAMP2 PIK3R3 AKT3 GSK3B CREM SLC6A1 IGF1R GABBR2 GABRA4 ARC KMT2A HMOX1 CAMK2A CDH11 ASCL1 SLC6A11 F2 PRKCA CALB1 APP CAMK4 CALB2 CREB1 PNOC NAPB JUN CASP8 FOSB PENK LIMK1 APOE TNFSF6 SOX2 SYT4 DLG4 PDYN PTGS2 TNF GRM2 FOS FMR1 EGR4 EPHB3 TCF7L2 STX1B CASP3 PMC6322225__F4 Treatment to health (HTD) network LPL tmp_locus_29 PC A2M ACD PMC8301018__F5 3H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus CDH2 MMP9 AKR1B1 PMC9307586__F12 MicroRNA expression profiling of endocrine sensitive and resistant breast cancer cell lines CDC42 F11R HEL-S-79 RAB31 THBS2 AKT3 PBX1 GSK3B PIK3R1 PTEN LAMC1 COL3A1 PSD3 COL4A4 LOX CCND2 COL4A2 COL4A1 ADAM12 MDM2 CAV2 FBN1 ATP1B1 CCDC81 VEGFA PTPRN2 GATA3 COL2A1 LOXL2 TCF7L2 UBE2H ITGB1 RNF43 IGF1 CLDN11 VAPA PDGFRA SNTB2 MAPK10 COL5A3 COL5A2 BIRC2 PMC4918817__F2 Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing, and disease FOXO3A MYF5 PAX7 NOTCH1 FGF2 PMC6925523__F3 Cellular signalling pathways in response to pathogenic viral infection or mtDNA release CGAS MAVS NLRP3 TLR9 IRF3 IRF7 PMC8132124__F3 Surviving the odds: From perception to survival of fungal phytopathogens under host-generated oxidative burst SRM ATM YAP1 HEL-S-44 PMC8596933__F6 CXCL14 facilitates the growth and metastasis of ovarian carcinoma cells via activation of the Wnt/Beta-catenin signaling pathway AXIN2 CXCL14 CTNNB1 PMC3140170__F10 Nicotine signal transduction pathways BAD RAF1 PMC7685213__F1 Simple Rx for congenital erythropoietic porphyria HMBS ALAS1 ALAS2 FECH UROD UROS PMC5267352__F1 Reviving the promise of transcription factor Nrf2 based therapeutics for kidney diseases HEL107 ENTPD5 GSTM1 KEAP1 NQO1 PMC6193498__F1 Homology-directed repair (HDR) and other pathways for the repair of double-strand breaks (DSBs) RAD51 BRCA1 BRCA2 PALB2 PMC10813911__F3 Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury GFAP SMAD2 PMC1502564__F3 Model diagrams indicating regulation and function of E47 activity GFI1B SOCS3 GFI1 PMC3967838__F1 DNA2 Resolves Expanding Flap in Mitochondrial Base Excision Repair DNA2 FEN1 PMC5450421__F4 Key enzymes in the glycolytic, pentose phosphate, pyruvate, and UDP-N-acetyl-galactosamine pathways are upregulated in the in vivo Giardia foci MAL PMC12222133__F3 Apoptosis in NPCs BAX MCL1 APAF1 FADD PMC12222133__F6 PANoptosis in NPCs CASP8 MLKL AIM2 DFNA5 RIPK3 NLRP12 GSDMD CASP6 ZBP1 NLRP3 CASP3 RIPK1 FADD PMC8274905__F6 Metformin Inhibits Lipoteichoic Acid–Induced Oxidative Stress and Inflammation Through AMPK/NRF2/NFKB Signaling Pathway in Bovine Mammary Epithelial Cells LTA COX2 GPX1 IL1B PMC6015873__F1 CAMKK2 as a molecular hub downstream in the bone–prostate cancer (PCa) microenvironment CAMKK2 BMP2 NFATC1 NUP62 CTNNB1 PMC5796897__F3 The fatty acid (FA) synthesis in different cell types ACLY LPL TG CD36 FASN PMC10778290__F7 Schematic diagram shows that tumor-derived ESM1 combines with the c-Met expressed by endothelial cells to promote GC peritoneal metastasis by inducing angiogenesis ESM1 HIF1A MMP9 VEGFA PMC5064021__F9 Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals IL10 ARG1 LAMTOR1 IRF4 PMC8535522__F1 Development of New Cancer Treatment by Identifying and Focusing the Genetic Mutations or Altered Expression in Gynecologic Cancers CDC2 ATR BRCA1 EGFR BRCA2 WEE1 ATM PTEN MDM2 MTOR PMC8055404__F3 Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions MAPKAPK2 EZH2 MTOR CTNNB1 PMC3667790__F7 DSG3 Facilitates Cancer Cell Growth and Invasion through the DSG3-Plakoglobin-TCF/LEF-Myc/Cyclin D1/MMP Signaling Pathway MMP7 DSG3 CCND1 PMC8602894__F7 Hsa_circRNA_103124 Upregulation in Crohn’s Disease Promotes Cell Proliferation and Inhibits Autophagy by Regulating the Hsa-miR-650/AKT2 Signaling Pathway TSC1 CDK2 PMC5480600__F3 Tumor-Associated Macrophages as Treatment Targets in Oncology CD40 COX1 COX2 C2 CCR5 CCR2 CCL5 SIRPG CD47 PMC8148341__F2 Microglial Exosomes in Neurodegenerative Disease MOS YKT6 RAB35 PELI1 PMC8148341__F1 Microglial Exosomes in Neurodegenerative Disease VTI1A CD81 CD9 VTI1B CD63 PMC8461092__F2 Interaction Between PEDV and Its Hosts: A Closer Look at the ORF3 Accessory Protein EIF2A TNF VPS36 PMC5494974__F3 Haploinsufficient tumor suppressor genes JUN EGR1 CDK6 CDK2 ATM MYC CDK4 PMC4545641__F1 The Expanding Role of Delta-like 4 Mediated Notch Signaling in Cardiovascular and Metabolic Diseases NOTCH2 NOTCH3 NOTCH1 PMC5517784__F5 Figure illustrating cumulative flux index in glycolysis, TCA cycle and electron transport chain in glucose metabolic pathway FH OGDH HEL-S-162eP CS MDH2 PMC8706317__F2 Improving the Health-Benefits of Kales (Brassica oleracea L. var. acephala DC) through the Application of Controlled Abiotic Stresses: A Review KEAP1 SFN PMC5494974__F5 Haploinsufficient tumor suppressor genes TSC2 SMURF1 TSC1 FOXO3A SMAD2 SMAD4 SMURF2 SKI PMC6042022__F7 Interactions between membrane–lipid metabolism, APP processing and Beta-secretase (BACE) activity, cholesterol uptake/efflux and cell cycle regulation ABCG1 PERP CKS2 APOE BACE1 LDLR CDK2 APP PLK1 S100B PMC8705541__F2 Thyroid Hormone Nuclear Receptor TRA1 and Canonical WNT Pathway Cross-Regulation in Normal Intestine and Cancer APC TCF4 CTNNB1 PMC11590683__F1 Catabolic pathways of glucose metabolism in KT2440 RPE RPIA TNLG7C PMC6445864__F7 Schematic illustration showing anti-inflammatory responses in RAW 264.7 cells after treatment with AS-6 TLR4 TNF IL1B MYD88 PMC4368090__F3 Interleukin-1B and its interacting proteins in Alzheimer’s disease TH SYK BAD GAL TIRAP LAT EGFR CD14 IL4 CS ARHA TNF MEF2C C2 BCR LYN PMC6538222__F3 The Keap1-Nrf2-ARE pathway RBX1 KEAP1 MAF PMC3154190__F5 Characterization of the MDSC Proteome Associated with Metastatic Murine Mammary Tumors Using Label-Free Mass Spectrometry and Shotgun Proteomics VWF THBS1 VAMP2 APOE HEL-S-7 LYZ ARG1 GP5 PTK2B GP1BA NOLC1 PPBP RHOB CD2AP CLTA ALOX15 Nbla10317 HLA-B LCN2 HLA-C CSTA CREB1 PS1TP5BP1 PF4 PMC9071071__F3 Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine KISS1 EED SIRT1 PMC7306218__F4 Identification of hydatidosis-related modules and key regulatory genes GDF3 UGT2B15 NR3A2 CLU NODAL PMC2929951__F8 Mapping Drug Physico-Chemical Features to Pathway Activity Reveals Molecular Networks Linked to Toxicity Outcome JUN TGFA ROCK2 APC GSK3B ARHA NEFL MYC NEF3 GPX1 CTNNB1 NEFH CBL GRB2 SRC DAAM1 PMC4000238__F2 The canonical Wnt, Ihh, Bmp and PTH/PTHrP signaling pathways in regulating the differentiation of mesenchymal precursors SOX9 IHH PTH RUNX2 COL2A1 PMC4000238__F1 Wnt pathway and its interactions with other pathways in bone ROR1 JUN APC ROR2 PTH PTH1R RUNX2 PMC9331941__F1 Immune Checkpoint Inhibitors in Cancer Therapy—How to Overcome Drug Resistance? HEL-S-92n STAT3 CD80 TIGIT CD24 BTK SIRPA CD47 LAG3 PMC5912161__F1 Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway NHS MAL PMC3603002__F6 T cell signaling pathways and protein phosphorylation sites identified to be differential between NOD and B6g7 mice in stimulated cells CDC42 LY9 SHC1 PXN LAT TXK CD5 PAG1 PTPN11 RHO PTPN6 ITSN2 CSK LCK PMC2661789__F1 In endothelial cells, after activation, VEGFR2 is able to stimulate the AKT/mTOR signalling pathway through PI3K RHEB PTEN PDK2 VEGFA ELF3 PMC3852343__F3 Oxygen-regulated COX subunit isoform switch in yeast and mammals CYC1 COX5A PMC9658148__F3 Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology HEL-S-101 SIX1 PITX1 SIX6 KRT14 TFAP2A NODAL PAX6 FOXG1 FSHB PITX3 SHH DLX5 PMC6325770__F7 Proposed CLIC4/Arf6 signaling pathway GIT2 BMPR2 CLIC4 AGAP2 ARF6 PAH RAB35 AGAP1 PMC9199004__F5 Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways STAT3 RASD1 HEL113 RAF1 SHC1 OSM TNFRSF10B PTPA TLR9 IRAK1 PTEN ATP2A2 MAP2 RUNX2 TRAF6 MAPK3 STAT1 OSMR TLR4 MMP3 CTGF JUN NEUROD1 BCL2L11 CHI3L1 MTDH CBFB IL6ST JAK1 MAP2K1 IFNB1 GRB2 TYK2 BCL6 PMC9199004__F4 Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways SGPL1 SMAD4 PTEN MAP3K11 CCL5 TGIF1 MYD88 LIPA TGFBR2 IFNG CEBPG DENR E2F3 IFITM3 SLC25A32 C10orf104 IL10 DICER1 HK2 IRF1 IL1A IRF4 CXCL10 FMR1 CBFB IGF1 SCARB1 CASP3 CALM1 IL7 TNFSF10 JARID2 PIGR PMC6385418__F1 Homologous recombination (HR) repair deficiency represents an opportunity for a synthetic lethality approach through the use of PARP inhibitors (PARPi) SSB PARP1 PMC9199004__F7 Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways CDC42 SRC PMC3978568__F1 Schematic representation and overview of PTEN/PI3K/AKT signaling and a model of the mechanism of peroxisome proliferator-activated receptor (PPAR) action TSC2 TSC1 PTEN MTOR CTNNB1 PMC11123998__F5 Supplementation influences the metabolic reprogramming of cumulus cells in aging ovarian patients HEL60 FH ENO2 ACO2 HEL-S-133P HK2 LDHB CS SDHA SDHB SUCLA2 HEL-S-32 ENO1 HEL-S-26 PMC6243101__F1 Autophagy as an anti-inflammatory process IL18 MTOR IL1B PMC8339131__F8 TRAIP as a key prognostic DEG between CTCs and metastatic lesions in osteosarcoma TRAIP KANK1 PMC8444451__F4 Identification of microRNAs and gene regulatory networks in cleft lip common in humans and mice FOXE1 WNT3A DVL2 RUNX2 AXIN2 FOXG1 RARA FOXD3 TP63 FOXP2 SHH APAF1 NR3B3 PMC4376601__F1 Sphingosine-1-phosphate receptor 2: a novel bile acid receptor and regulator of hepatic lipid metabolism? FGF8A NR1C1 MTTP VLDLR S1PR2 IL16 CYP7A1 FGFR4 PLTP IRS1 PMC3096022__F1 Biochemical pathways leading to the synthesis of TAG and cholesterol HMGCR SCD FASN PMC4737457__F4 Crosstalk between Wnt, Notch, and JAK-STAT signaling pathways STAT3 BMP2 RBPJ PMC11039990__F7 Genomic overview of INA-induced NPR1 targeting and transcriptional cascades in Arabidopsis TF INA PMC8306599__F2 Advanced Glycation End Products: New Clinical and Molecular Perspectives STAT1 VCAM1 JAK1 PMC4621888__F1 Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder STAT3 TET2 STAT1 PAK1 ROCK1 ASXL1 KIT ARHA RAC1 GAB2 PMC11147929__F6 LSS affects endothelial cell pyroptosis through IKKE/STAT1/NLRP3 signaling pathway STAT1 GSDMD NLRP3 IL18 PMC3192838__F7 Hepatitis C Virus Reveals a Novel Early Control in Acute Immune Response MAVS TRIM25 TRAF3 ISG15 EIF2A PMC11858545__F8 Danggui Beimu Kushen Pill Alleviates Colitis-Induced Inflammation in Mice by Regulating the IL-6/IL-6R and IL-17A/IL-17RA Signaling Pathways STAT3 JAK1 TRAF6 PMC4600500__F4 Interactomic analysis by ingenuity pathway analysis (IPA) of significant molecules IFNG RELA REL CCL2 CXCL8 PMC4772101__F2 Mechanical signaling and tissue growth CTNNB1 PMC8825714__F5 UHPLC‐QTOF/MS‐based comparative metabolomics in pectoralis major of fast‐ and slow‐growing chickens at market ages ACHE GPCPD1 ChAT PHOSPHO1 GDE1 PMC8024479__F3 Intrinsic apoptotic pathway HTRA2 BAX SPHK2 ATF4 MDM2 EIF2A TRAF2 DIABLO PMC5037772__F5 Pin1 regulates multiple signal transductions in metabolic organs STAT3 DCSTAMP SMAD2 CRTC2 PIN1 RUNX2 MEF2C IRS1 CTNNB1 PMC8458575__F2 Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism MTHFD2 TSC2 CAD TSC1 ATF4 PMC5037772__F4 Pin1 has biphasic effects on insulin signaling PI3 PIN1 IRS1 PMC6089072__F3 Methods for observation and quantification of apoptosis FAS OMP TNF PMC7276052__F7 Main components of RAAS pathway active in small bowel (SB) Crohn’s disease (left) compared to non-IBD (right) SLC6A19 ACE2 PMC7826706__F1 Hedgehog (Hh) signaling pathway contributes to hepatic carcinogenesis CD44 ABCC1 SUFU SMAD2 PTCH1 SMAD4 SMO TAP1 PMC6403405__F8 Functional mechanisms of COL2A1 on the BMP-SMAD1 pathway BMPR2 SMAD1 ITGB1 SMAD4 ITGAX PMC8389254__F3 Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?” LAMP2 ULK1 BNIP3 MTOR PMC6942938__F1 Proteome alterations in aqueous humour of primary open angle glaucoma patients DKK3 AXIN1 WNT1 ARHA APC2 RAC1 WIF1 CTNNB1 PMC11360076__F4 Protein–protein interaction map of the upstream regulators that significantly altered after the exposure to V CD3D FUS ADORA2A CHTOP TRAPPC1 CGA MAP3K12 MLXIPL RBM47 PIK3R1 TRIM2 UCP1 HSF2 CYP27B1 RCN3 NRAS HTT NUP133 RAD51 SELL PLAUR SLC2A3 OVOL2 FOS ALDH3A2 FMR1 COL18A1 CUL4B ADAM10 MAP2K5 MYO1B HEL-75 IL15 RGS2 HELLS STK11 PTEN SGPP2 XBP1 ALDH2 SPNS2 EP400 DCX ARNT2 WTAP ATF4 SELENOW ZFHX3 RNF5 LARP1 NR2A1 PRL CLPP PBR TPP2 STAT4 PMC2730725__F1 Nm23-H1suppression of tumor metastasis may depend on at least three pathways L1CAM SET STRAP PMC3248218__F3 NUAK2: an emerging acral melanoma oncogene RHEB TSC2 TSC1 MTOR PMC6628314__F1 Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2-Mutated Breast Cancer NRG2 NRG1 EGFR NRG3 PTEN SRC NRG4 PMC4544004__F8 The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway TLR4 MAL TRAF3 TRAF6 IRAK4 FADD PMC9116428__F1 Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NFKB Signaling Pathway ECSIT CD80 TRADD MTOR TRAF3 TRAF6 CCL2 CXCL8 MYD88 TLR4 BDNF TRAF2 FADD PMC4544004__F1 Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway MAL TLR9 IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 FADD PMC8175077__F2 Intracellular Free Neu5Ac Metabolism and Associated Genetic Disorders GNE SLC17A5 NPL SLC35A1 PMC10993482__F5 Gal-1 pathways promoting EMT in cancer S1PR1 TLR4 SMAD2 SMAD4 MTOR CTNNB1 PMC10993482__F4 Gal-1- and Gal-3 pathways promoting EMT in fibrosis SMAD2 SMAD4 CTNNB1 PMC5731874__F6 Osteopontin production by TM4SF4 signaling drives a positive feedback autocrine loop with the STAT3 pathway to maintain cancer stem cell-like properties in lung cancer cells CD44 STAT3 GSK3B SRC TM4SF4 CTNNB1 PMC4032097__F9 CNTF-induced gliosis in the retina after ONC and Pen1-C6DN + siCASP2 treatment CNTFR CNTF CASP6 CASP2 PMC7829348__F2 Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions TBK1 TIRAP TLR4 TAB3 CD14 IRAK1 IRF3 TRAF3 TRAF6 LBP IRAK4 MYD88 PMC11566834__F8 Optogenetic stimulation of the “Zusanli” acupoint alleviates inflammatory pain through active Wnt/Beta-Catenin and MAPK signaling pathway in rats APC GRB2 CTNNB1 PMC10993482__F6 Gal-3, Gal-4 and Gal-8 pathways to EMT in cancer EGFR IGF1R RUNX2 CTNNB1 PMC9496846__F4A Systematic Analysis of Genetic and Pathway Determinants of Eribulin Sensitivity across 100 Human Cancer Cell Lines from the Cancer Cell Line Encyclopedia (CCLE) MAX HNRNPL SYK EGF KRT10 TCF12 PCNA EGFR SMC3 TUBB MYC CTCF CBL NR3A2 VAPA CFTR APP EP300 MAP2K3 XPOT HEL2 YWHAZ PMC2901811__F4 II S and TOR-signaling pathway in Drosophila RHEB TSC2 TSC1 PTEN PMC11011897__F3 Proteomic Analysis of Salivary Extracellular Vesicles from COVID-19 Patients Reveals a Specific Anti-COVID-19 Response Protein Signature TF LAMA5 FBN1 HSPG2 HEL-S-78p LAMB1 KRT6A ALB COL1A1 CLU COL4A2 COL4A1 FGA HP CP PMC10458543__F5 Protein interaction network created using STRING database based on Bos taurus genome CD40 TICAM2 TLR9 IRF3 IRF7 IL6 CXCL10 TRAF6 MYD88 NLRP3 TLR3 NFKB1 IFNAR1 TLR7 IFNB1 CD8A TYK2 IL23A PMC7491318__F11 Protein interaction network for 105 DAPs listed in GNL2 SPARC PCOLCE ZWINT DDR2 COXFA4 CD109 KDM4A GC20 HMOX1 GRB10 RCN3 SPC24 PLOD2 TMSB10 DNAJB1 AXL HMCES CTSL GLIPR2 TAF9 TXNDC15 CDK105 HIGD1A PHLDA3 POLR2G POLR2I ABCF3 POLR2B PUM3 RNF181 EN1 ADFP MMP14 CDC20 RASSF1 CKS2 P4HA2 CHTF18 CENPE FADS3 COL1A1 PNO1 UCK2 DHRS1 GAS1 C4B_2 POLR2A TSEN15 PLOD1 NDUFC2 SDCBP GNG10 CIRBP SIK3 PTGS2 NOSIP NUSAP1 EDF1 GYS1 DCAF13 POLDIP3 SUI1 SLC38A4 CPQ JAK1 SERF2 SDF4 PMC7583982__F2 Functions of miRNAs in EOC metastasis CDH2 MTOR PMC3075242__F6 Differential Expression of MicroRNAs in Tumors from Chronically Inflamed or Genetic (APCMin/+) Models of Colon Cancer CRP MAX IDE BAX JUN BAD APC OCEL1 MYC RBL1 CRK NF1 ATM MDM2 LEF1 FADD PMC5882792__F1 Mitochondrial UPRmt and UPRam stress response pathways UBL5 ATF5 MAVS CLPP ATF4 PMC8553480__F3 MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer DLG2 BAX LRRK2 MMP10 SMAD4 MMP2 PTEN ZEB2 TCF21 VEGFA CTNNB1 RUNX3 PMC9555037__F7 Ruscogenin Protects Against Deoxynivalenol-Induced Hepatic Injury by Inhibiting Oxidative Stress, Inflammation, and Apoptosis Through the Nrf2 Signaling Pathway: An In vitro Study KEAP1 NQO1 GCLC PMC8553480__F2 MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer RAN DGCR8 XPO5 AGO2 DROSHA PMC2776915__F1 A genetic model for sex determination, controlled by a balance of antagonistic pathways FOXI2 FOXL2 SOX9 SRY FGF9 WNT4 CTNNB1 RSPO1 PMC7325493__F1 Complex Signaling Network Driving Macropinocytosis in Cancer EGFR LRP5 LRP6 PTEN RAC1 CTNNB1 PMC3249400__F1 AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism GBF1 TSC2 CAMKK2 GYS1 ULK1 FOXO3A CRY1 CRTC2 HDAC5 HDAC7 KLC2 IRS1 PMC7291262__F2 MiRNAs/CD133 axis in glioblastoma signaling pathways PLD2 SHH NOTCH2 PMC3249400__F2 AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism RHEB TSC2 MAP3K7IP1 TSC1 FYN NF1 ULK1 ATM FLCN PTEN MTOR FNIP1 PMC6332464__F2 Schematic representation of glycolysis, the pentose phosphate pathway (PPP), glutaminolysis and lipid synthesis and their inhibition by polyphenols in breast cancer cells HEL-S-133P PHGDH F2 PMC8421037__F2 YAP/TAZ activity is central to coordinating cell migration THBS1 ARHGEF17 TEAD2 TEAD3 ARHGAP18 ARHA ARHGAP29 TEAD4 PMC8421037__F1 Mitosis by the Hippo pathway and YAP/TAZ LATS1 CDC2 CDK8 CDC26 CTCF LATS2 TEAD2 TEAD3 APC TEAD4 PMC3249400__F4 AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism FASN CRY1 HDAC5 SIRT1 PMC8136213__F7 Symbiotic relationship between Caenorhabditis elegans and members of its microbiome contributes to worm fitness and lifespan extension CYS1 PNP SGK1 PMC11936079__F3 Involvement of EMR2 in Wnt/Beta-catenin signaling pathway PDPN CHD3 DDX5 NF1 AGR3 FOXL1 PMC8760362__F2 Zika virus infection of the placenta alters extracellular matrix proteome AHSG HEL-S-92n MAK GCA KIT MICA HP PMC3145765__F9 Cardiomyocyte Specific Ablation of p53 Is Not Sufficient to Block Doxorubicin Induced Cardiac Fibrosis and Associated Cytoskeletal Changes TF BAX MAP4 CASP3 PMC8772744__F5 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease SMAD2 SMAD4 PMC8772744__F4 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease KEAP1 GSK3B PMC3070572__F4 Schematic analysis of the regulatory pathways in BOO in AROM+/6J male mice PCNA PTEN COL3A1 PMC4648799__F2 P2Y receptor (P2YR) signaling in neurons counteracts oxidative stress and Alzheimer’s pathology ADAM17 APP ADAM10 PMC8772744__F2 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease ULK1 PTEN MTOR PMC8772744__F1 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease BAX TRADD C2 IRAK1 RIPK1 TRAF2 IRAK4 FADD MYD88 PMC2828280__F2 Canonical Wnt pathway BCL9 MMP7 TIAM1 APC LRP5 MMP3 LRP6 ADAM10 CCND1 CTNNB1 PMC4061726__F1 Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson’s disease CDC42 APC ROR2 LRP5 RYK ARHA GPR49 LEF1 LGR6 PMC3701522__F1 Wnt signalling pathways implicated in diabetic nephropathy CDC42 APC GSK3B ARHA UNK DAAM1 CTNNB1 PMC6385756__F7 Diagram depicting the prostanoid synthesis pathway and the effects of PGE2 on its receptor subtypes PTGER2 PTGER3 TBXA2R PTGR1 PTGS2 PTGDR2 HPGD PTGER1 PTGS1 PTGES PTGER4 PTGFR PTGIR PMC8123861__F1 PGC-1A in the Mitochondrial NAD+ Pool in Metabolic Diseases NMNAT1 NAMPT NMNAT2 NMNAT3 PMC5588108__F3 The Hedgehog signaling pathway BMI1 SUFU PTCH1 SHH SMO PMC3705708__F1 Hedgehog Signal Transduction Network KIF7 BOC SUFU SMO PMC9024590__F3 Boolean Model of the Proliferative Role of the lncRNA XIST in Non-Small Cell Lung Cancer Cells HDAC1 BAX ATM MDM2 PMC7583982__F1 Biogenesis and functions of miRNA DGCR8 PAN2 PAN3 DROSHA PMC2648546__F8 A new feedback loop for p53 pathway BAX CDK2 MDM2 PMC9271889__F5 Autophagy in health and disease: From molecular mechanisms to therapeutic target TMEM41B ATG16L1 ATG12 ULK1 SNAP29 STX17 ACE2 PMC3936891__F1 Overview of the folate-methionine metabolic pathway investigated in this study MTRR PMC9218499__F1 Taste Receptors in Innate Immunity and Oral Health IL25 TRPM5 PLCB2 CALHM1 PMC6789489__F1 Action of methylxanthine (MTXs) in glioblastoma (GBM) GFAP MTOR HDAC2 PMC10034056__F2 Effect of Bifidobacterium on osteoclasts: TNFA/NFKB inflammatory signal pathway-mediated mechanism NFATC1 TRAF6 PMC10034056__F1 Effect of Bifidobacterium on osteoclasts: TNFA/NFKB inflammatory signal pathway-mediated mechanism TRADD NFATC1 TRAF2 PMC2676446__F1 Regulation of p53 and MDM2 and the outcomes of p53 activation BAX ATR FAS ATM MDM2 XPC PMC8834112__F4 Drosophila melanogaster: A Model System to Study Distinct Genetic Programs in Myoblast Fusion CRK PAK1 ARF1 PI3 PMC6441234__F1 Illustrative diagram for exosome-mediated transfer of therapeutic resistance in the tumor microenvironment (TME) CD9 EGFR RBM11 TSG101 PTEN CD63 PMC9035423__F4 Lactate-induced effects on bovine granulosa cells are mediated via PKA signaling RGS2 FSHR LHCGR VNN2 PMC6637313__F1 Cellular and molecular responses to extracellular and intracellular DNA DNASE1L3 CD40 IFNG HMGB1 DNASE1 CGAS BCR TREX1 DNASE2 MYD88 PMC5087334__F6 MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage TRIO BCL10 ARHA RHO CYLD PMC10531837__F2 Exploring the Complex and Multifaceted Interplay between Melanoma Cells and the Tumor Microenvironment NF1 APC GSK3B BRAF PTEN PMC10531837__F1 Melanin production MC1R DCT TYRP1 PMEL PMC10531837__F4 Phenotype switching in melanoma PAX3 MCAM SNAI2 JUN AXL EGFR NGFR SOX2 DCT TCF4 TFAP2B SOX10 FAP IRF4 SOX6 FOXD3 SNAI1 SOX9 ZEB2 TWIST1 SOX5 AQP1 PMC10886467__F2 An illustrative representation and overview of PINK1, Parkin, and related molecules in the regulatory pathway for mitophagy TBK1 PINK1 PARL MFN1 MFN2 OPTN PMC7790891__F2 Regulatory network of ginsenosides in macrophage CRP RB1 MTOR PMC9214054__F8 Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism DDB2 PAQR3 PMC7790891__F1 Regulatory mechanisms of ginsenosides in HUVEC RB1 BAX LOX KEAP1 VCAM1 PMC6643028__F1 GPCR signaling CDC42 SHH RHO MTOR CTNNB1 PMC6313651__F1 Gut Microbiota, Fusobacteria, and Colorectal Cancer TIGIT AHR CTNNB1 PMC5237710__F2 PI3K/Akt/mTOR pathway involved in tumorigenesis and metastasis BAD GSK3B PTEN CCND1 EIF4E PMC3368076__F6 Proposed mechanisms of leptin and glucocorticoid stress hormones in the GSK3B/Beta-catenin signaling pathway STAT3 GSK3B CTNNB1 PMC10886467__F1 Relevant signaling pathway potentially being involved in the pathogenesis of polycystic kidney disease (PKD) and/or chronic kidney disease (CKD) RICTOR PTEN MTOR PMC3832598__F7 CD43 Promotes Cells Transformation by Preventing Merlin-Mediated Contact Inhibition of Growth FAS MDM2 PMC3399969__F5 State-of-the-science: An update on renal cell carcinoma RHEB TSC2 TSC1 GSK3B PMC7147542__F2 Sonic hedgehog (SHH) pathway SUFU SHH SMO PMC9532747__F1 MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy PLA2R1 AHR PAH PMC12133616__F5 Stepwise presentation of the NF-kB signaling pathway RPS3 TNF PMC6713153__F2 Signalling pathway induced by ManLAM TLR1 MYD88 PMC7136098__F2 Signaling options initiated via wnt5a and the concluded outcome ROR2 MSC NFATC1 RHO DAAM1 PMC8522911__F1 Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies IRAK1 TLR5 IRF3 IRF7 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC10571545__F5 TF–FVIIa–driven PAR2 activation triggers EV generation from human TNBC cells, which promotes EMT in non–metastatic breast cancer cells, leading to the induction of proliferation, migration, invasion, and anti–apoptosis CDH2 PTEN PMC8367394__F12 PPAR signaling pathway regulated by high the concentration of ciglitazone LPL UBC AQP7 UCP1 PLTP PMC7136098__F1 Canonical and noncanonical signaling options initiated via wnt3a and the concluded outcome WNT3A APC LRP5 MSC LRP6 NFATC1 RHO DAAM1 CTNNB1 PMC3381650__F3 Signaling Networks of the Herpesvirus Entry Mediator (TNFRSF14) in Immune Regulation APC CD160 BTLA GRB2 PMC6317263__F2 Milk exosomes and allergy prevention SOCS1 DKFZp781O1323 IL2 ITK FOXP3 PMC3109223__F1 MTOR signaling pathway RHEB TSC2 TSC1 PTEN CTNNB1 EIF4E PMC5612430__F1 Choline and methyl group metabolism and its relation to DNA methylation and influence on regulation of gene expression: a simplified diagram CHDH ChAT HEL-S-61p MTR MAT1A PMC4174543__F3 Activated STING in a Vascular and Pulmonary Syndrome TBK1 CGAS STAT2 IRF3 JAK1 TYK2 PMC10570830__F2 PIFs are the key regulators of skotomorphogenesis RFWD2 BIN2 DDB1 DET1 PMC4958499__F1 Looking beyond structure: membrane phospholipids of skeletal muscle mitochondria PSD TAFAZZIN PEMT PC PMC6953096__F4 Representation of DEGs in major signal transduction pathways, in 5a treated cells POR EPO RHO MTOR PMC3866156__F1 Proposed mechanisms of aspirin, the single nucleotide polymorphism rs6983267, and their interaction on the WNT/CTNNB1 pathway TCF7L2 COX2 APC GSK3B MYC CCND1 CTNNB1 PMC9028943__F2 Fate of Leydig Cells in Men with Spermatogenic Failure CYP17A1 CYP11A1 PMC4582105__F3 Defects in ribosomal biogenesis activate p53 and other stress-response mechanisms POLL POLI MDM2 MYC PMC8301837__F3 Wrestling and Wrapping: A Perspective on SUMO Proteins in Schwann Cells PAK1 TFEB RAC1 SENP3 PMC8301837__F2 Wrestling and Wrapping: A Perspective on SUMO Proteins in Schwann Cells PAK1 SOX10 NOTCH1 PMC6707613__F9 Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers TNF IRS1 PMC3482395__F2 Canonical biogenesis pathway and mechanisms of miRNA deregulation DGCR8 MYC DROSHA PMC9164068__F6 Luteolin on Human Breast Cancer Using Gene Expression Array: Inferring Novel Genes CYR61 OXTR NDUFV3 HLA-DRB1 PPP3R1 HLA-DOA PTPRF HLA-DPB1 HLA-DRB5 NLGN1 PCSK9 LPA FIG4 SOST HLA-DRA APP HLA-DRB4 CCNB1 PPP1R3E THBS1 CFH CEMIP VEGFA SORCS2 RHOV RAB15 XB LEPROT GPNMB ZNF207 THBS4 CCDC80 CLCN4 PMC7376433__F1 Molecular pathways involved in hereditary cancer risk BARD1 MSH6 RAD50 MSH2 PMS2 MRE11A NF1 CHEK2 ATM MTOR PALB2 PMC6406288__F3 Consequences of indoleamine 2,3 dioxygenase (IDO) overexpression on the antitumoral immune response IFNG ETV4 KIT AHR PMC7343507__F7 The regulatory role of miR-9 and miR-29a in DPN ISL1 SHH HEL-S-11 PMC3074148__F5 Schematic representation of the two degradation pathways followed by MicA RNASE3 RAF3 MICA PMC9269291__F5 Potentilla paradoxa Nutt. Ethanol Extract Exhibits Anti-Inflammatory Effects by Suppression of the Src/NFKB Signaling Pathway TLR4 SRC MYD88 PMC8773732__F1 Macrophage Involvement in Medication-Related Osteonecrosis of the Jaw (MRONJ): A Comprehensive, Short Review SOCS1 IFNG STAT1 NLRP3 TLR4 SOCS3 RHO TRAF6 TNF IL1B PMC8657824__F1 The Membrane Trafficking of the Mechanosensitive Ion Channels TRPV1 and TRPV4 by Zonular Tension, Osmotic Stress and Activators in the Mouse Lens TRPV1 OSR1 SET PMC4822134__F2 Ubiquitin regulation of TLR signaling TBK1 TAB3 IRAK1 IRF3 TRAF3 TRAF6 IRAK4 PELI1 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 RELA TRAF2 PMC151358__F5 JNK-dependent apoptosis signaling pathway HTRA2 BAX BMF STS PMC7007115__F2 Dietary Restriction RHEB TSC2 NR1C1 TSC1 IGF1 PMC4822134__F1 Main signaling pathways of PRRs TBK1 CGAS TIRAP MAVS TAB3 TLR9 IRAK1 TLR5 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 NOD2 TRAF5 TLR8 TLR7 TRAF2 PMC7175140__F6 TGFB non-SMAD signaling pathways CDC42 TF TRAF4 STAT3 SMURF1 SMAD6 ARHA GRB2 SMURF2 TRAF6 RAC1 PMC7175140__F3 TGFB/SMAD signaling pathway TF SMAD2 SMAD4 PMC8695973__F2 Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System EMX2 GSX2 ASCL1 DMRTA1 DMRTA2 PAX6 DMRT3 FOXG1 PMC7398577__F3 Viral miR-mediated evasion of adaptive immune responses CXCL11 ERAP1 IFI30 MICA CCL5 MICB PMC7398577__F2 Viral miR-mediated suppression of host innate immune pathways STAT3 TBK1 TIRAP MAVS TAB3 TLR9 CD14 IRAK1 IRF3 IRAK2 IRF7 SOCS3 TRAF3 TRAF6 IRAK4 IL6R MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC8935981__F8 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches TH CTNNB1 PMC3527608__F6 Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct Mechanisms BAX BAD FAS BCL2 GIP FADD PMC8935981__F7 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches MAPK14 SUMO1 RAN ATR MAP3K1 MAK ATM SETDB1 MAPK12 MAP2K3 PMC8935981__F9 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches SCD FASN CREM HP ACACA PMC2833108__F7 TNFSFR and NFKB signaling activation during macrophage activation: CpG late responses CD40 CASP9 JUN CAD CASP8 TRADD TRAF3 TNF TRAF6 FOS MYD88 MAP3K7IP1 CASP6 COX2 CASP3 TRAF1 FADD PMC8268514__F1 Review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations CDC42 BAD PTEN MDM2 GRB2 MTOR SRC RAC1 PMC2833108__F6 Sonic Hedgehog, Wnt and TGFB signaling pathway gene expression in CpG late treated macrophages [; ; ; ], see discussion NCAM2 SMAD2 APC GSK3B SHH BMP7 SMO CTNNB1 PMC7052372__F2 Innate immune receptors present in cholangiocytes MAVS NLRP3 TLR3 TLR4 IRAK1 IRF3 IRAK4 MYD88 PMC3241960__F5 Sarcolemmal actin assembly and nuclear signaling MAL RHO PMC9694420__F1 PIK3CAMutations in Breast Cancer Subtypes Other Than HR-Positive/HER2-Negative BTK C2 PI3 PTEN PMC8348432__F8 Trans-(−)-Kusunokinin: A Potential Anticancer Lignan Compound against HER2 in Breast Cancer Cell Lines? CDK6 RALA CCNB1 CCND1 CDK4 PMC9446754__F5 CD47 as a promising therapeutic target in oncology BNIP3 MIOS CD47 PMC3624606__F1 Oncogenes and tumor suppressor modulate metabolic reprograming in cancer cells GLS PTEN TIGAR MYC PMC6754502__F5 Broiler thymus predicted to have less cell migration in response to the Thermoneutral + LPS treatment compared to Fayoumi S1PR3 ENG CSF1 RHOB DMBT1 PMC4405775__F1 Dependence on signaling pathways based upon tumor suppressor status STAT3 PI3 ARHA SRC PMC5118777__F3 Schematic indicating the role of cellular and EBV miRNAs in EBV latency and reactivation ZEB2 CEBPB HIVEP2 PMC3520003__F1 Simplified summary of the role of ATGL in macrophages.FFAs which are taken up by macrophages are incorporated into TGs (and cholesteryl esters) CDC42 LPL TG ARHA RAC1 PMC10905161__F2 Nrf2/Keap1 signaling pathway MTHFD2 FAS KEAP1 CD36 ULK1 GCLM HMOX1 RBX1 BACH1 NQO1 GCLC HEL-S-26 MARCO CALCOCO2 PMC3779571__F1 Chondrocyte gene network of CSGalNAcT-1 was classified as glycan biosynthesis and metabolism and functional pathway MGAT2 RELA LEPROT UST CHPF PMC6027307__F1 Noncanonical NFKB signaling pathway CD40 RELB TRAF3 TRAF2 PMC7304783__F6 Possible mechanism associated with the tumor-suppressing effect of Romidepsin in DEN-induced HCC mouse model BAD DKK1 LRP6 PTEN CYLD CCND1 CTNNB1 PMC11600033__F12 HA/PEI-RH NYPs for UC treatment CD44 NPS MYD88 PMC4422447__F1 Angiotensin II, transforming growth factorB, and Smad signaling pathways SMAD2 SMAD4 PMC5783849__F9 TIPE1 and Wnt/beta‐catenin signalling pathway in gastric cancer APC LRP5 LRP6 CTNNB1 PMC9150370__F2 Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms SIRT3 NLRP3 GSK3B PMC6374752__F1 Tryptophan-kynurenine pathway and major functional consequences in the context of GBM growth IDO1 IDO2 PMC8944478__F6 Identification and Molecular Analysis of m6A-circRNAs from Cashmere Goat Reveal Their Integrated Regulatory Network and Putative Functions in Secondary Hair Follicle during Anagen Stage DLG2 SKIL SMAD9 CXCL12 PLCB4 DKFZp781O1323 AKT3 BRAF PTEN ATF2 PPP3CC TGFBR2 BAMBI FRMD6 WWTR1 CAMKK2 ARHGEF12 ITGA2 LDLR AHR CCND1 DCN CREB1 BMPR2 EFNB2 REST APC VEGFA PITX2 HOXD10 GNG2 TCF7L2 ITGB1 CAMK2D PLCB1 BMP2 NEO1 FGFR3 EP300 WNT3 SDC2 LEF1 YWHAZ PMC5831768__F2 Non-canonical Shh signaling in commissural axon guidance GPC1 HHIP BOC SHH SMO PMC3238080__F2 Regulation of intracellular signaling by antiepileptics and modulators of glutamate, acetylcholine, and melatonin systems EEF2 BDNF NACA PMC8831078__F2 Ubiquitination of AMPA receptor subunits HEL-S-71 APC RNF167 USP46 MDM2 UBE2D1 PMC11206339__F1 Common synthesis pathway for testosterone from cholesterol and its subsequent conversion into estrogenic and androgenic active metabolites HSD17B3 CYP17A1 CYP11A1 HSD3B1 PMC5321522__F1 Clinical imaging of cancer metabolism FAS GLS F2 TIGAR PMC4134348__F1 Lung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization TH TIRAP TLR4 IRF3 TNF IRAK4 PMC8369426__F2 Phytochemicals: Targeting Mitophagy to Treat Metabolic Disorders PINK1 OPA1 PGAM5 PARL ULK1 MFN2 BNIP3 FUNDC1 PMC8010610__F1 RAS Signalling Pathway (90% of JMML cases involve mutations in the RAS pathway): N/KRAS proteins (in Pink) alternate between “ACTIVE” and “INACTIVE” states NF1 PTPN11 GRB2 MTOR KRAS GAB2 PMC9535022__F3 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials SLC3A2 KEAP1 PMC9535022__F2 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials EGFR FGFR1 CDK2 PTEN MDM2 CDK4 PMC9535022__F4 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials MAX SUZ12 SOX2 EZH2 MTOR BCL11A SET NSD3 ME3 RBBP7 FBXW7 RBBP4 ME2 PMC9535022__F6 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials CXCL9 FZR1 SPOP IL3 IL2 EZH2 PTEN CXCL10 CDK4 PMC6808435__F10 RNA-Seq analysis reveals an essential role of tyrosine metabolism pathway in response to root-rot infection in Gerbera hybrida PMC4511781__F1 Insulin and IGF-1 signaling in gray mouse lemursIR and IGF-IR share a similar signaling pathway which invokes downstream changes in two main branches – the mitogenic pathway (Ras/Raf/MEK/ERK) and the metabolic pathway (PI3K/Akt) RPS6 TSC2 TSC1 IGF1 GSK3B PTEN IGF1R MTOR IRS1 PMC6025294__F2A JMY in p53 Regulation JMY ATM MDM2 STRAP PMC6149912__F1 Inhibition of DDR1-BCR signaling by nilotinib CD44 JUN DDR1 BCR MYC GPR49 CCND1 FOS CTNNB1 PMC5165017__F1 Working Hypothesis of mechanotransduction in EC cells PIEZO2 PMC7462039__F2 Engineering Brain-Specific Pericytes from Human Pluripotent Stem Cells CDH2 TGFBR2 SMAD1 DKFZp781O1323 ALK SMAD2 VTN SMAD4 VEGFA CTNNB1 PMC7462039__F1 Engineering Brain-Specific Pericytes from Human Pluripotent Stem Cells SP1 FOXO1 EGFR RHO MTOR PMC3933348__F1 Overview of tamoxifen metabolism pathway and the main enzymes involved CYP2B6 CYP2C19 CYP2C9 PMC8664518__F1 Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective IL19 NLRP3 PMC6491677__F1 Metacore™ map showing the signaling context of the genes contained in the “Vascular endothelial cell damage in SLE” pathway HMGB1 HGF VEGFA CCL2 HEL-S-100n TNF TRAF2 PMC10743522__F3 The signaling pathways regulated by phase separation during development BMP4 MYC CTNNB1 PMC1087795__F1 Schematic depiction of the S GPD2 PC GPD1 PSD2 PMC9524038__F2 Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption NELL1 APC RUNX2 CTNNB1 PMC3726950__F2 Regulation of autophagy pathways and targets for modulating autophagy by drugs/compounds RHEB EGFR HEL-S-11 MTOR INS PMC7915952__F1 Canonical pathway of microRNA (miRNA) processing DGCR8 AGO2 DROSHA PMC7225923__F2 Cancer cell dormancy POSTN VTN BMP7 MTOR VEGFA TNF PMC3193409__F4 Expanding role of ubiquitination in protein kinase activation in diverse NFKB pathways TBK1 MAP3K7IP1 MAVS TRIM25 BCL10 TAB3 ATM IRF3 TRAF3 TRAF6 TRAF2 PMC9520190__F3 Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma IGF1 PTEN IGF1R GRB2 IGF2 IRS1 PMC7546851__F1 Neutrophils in TME STAT3 HGF TGFA MMP12 CXCL5 MCL1 CXCL1 ELF2 CXCL2 EIF4E MSC BCL2 CXCR4 PMC2845723__F2 The bile salt synthetic pathway CYP7A1 HSD3B7 CYP27A1 PMC5069771__F2 Genes upregulated after RSV infection IFNA13 DGIC CMPK2 CCL5 CXCL8 OTOF IFNG OSMR CCL7 RTN1 HEL-S-11 NR1i1 FAT10 NOS2 FCER1A ERAF STAT2 IRF7 OAS3 SAMD9L TNF CXCL11 HEL110 HLA-B LCN2 DEFA1B TF IL15 OLFM4 CD177 MPO MUC5AC PFDN5 IFITM3 ALOX15 MX2 CEACAM6 MX1 ISG15 TMC5 OAS1 OAS2 GNLY HEL-S-72p IL10 ANXA3 PSMB8 IRGM DEFA4 GBP1 LAMP3 CHI3L1 IFIT5 NFKBIA MS4A6A HP GMPR TNLG7A KLRB1 MYD88 GBP4 TFF2 RTP4 IF2D USP18 OASL KLRD1 EIF2AK2 NMI ALYREF SERPING1 SERPINA3 IFITM1 AIM2 LGALS9 RSAD2 ALAS2 ATF3 XRCC5 LAP3 HBD TSPAN8 AIF1 CCL4 CCL8 CEACAM8 LMNA CXCL9 HEL-S-62p IFIT1 DHX58 IL18BP ISG20 HELZ2 HLA-G EPSTI1 ELANE GBP2 JUN CD14 BATF2 CXCL2 IL6 MMP9 FCGR1A SCGB1A1 PRF1 LILRB4 S100A12 PMC9504325__F1 Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies DEFB4B HEL-S-130P NOD1 PMC11906358__F5 Balancing dopamine levels by clock components TH PER2 CRY1 MAOA PMC8426673__F1 Lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses ADAM17 ACE2 PMC11906358__F4 Molecular model of light-induced signalling pathways for clock phase shifting JUN SIK1 CDK5 PER2 GEM PER1 DUSP4 FOS CRTC1 PMC8892088__F1 Metabolic regulation of ferroptosis in the tumor microenvironment SLC3A2 GPX4 SLC7A11 PMC5068231__F7 Cpb1–C3–C3aR pathway amplifying p38 MAPK signaling downstream of TLR4 and Ifnar activation in macrophages IFNG NOS2 HEL-S-62p TLR4 CPB1 IL6 TNF PMC7385189__F2 Primary resistance CXCL9 EGFR PTEN TOX B2M CTLA4 MTOR CXCL10 CXCL8 LAG3 CTNNB1 PMC8892088__F4 Metabolic regulation of ferroptosis in the tumor microenvironment IFNG SLC3A2 STAT1 GPX4 SLC7A11 PMC8892088__F5 Metabolic regulation of ferroptosis in the tumor microenvironment CD36 AGER GPX4 MITA PMC4984446__F1 The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease RPL5 RPL11 PAK1IP1 MDM2 PMC7465818__F1 Canonical NFKB pathway can be activated via multiple different ligand/receptor interactions CD40 BCR RELB PMC3956512__F1 The unfolded protein response (UPR) pathway in Cryptococcus ATF4 EIF2A XBP1 PMC7352466__F2 Biological effect of PARPi on cancer cells TBK1 CGAS IRF3 CCL5 CXCL10 PMC3569094__F1 Novel therapeutic approaches for overcoming limitations in the gemcitabine pathway CDA RRM1 RRM2 PMC11764055__F2 Mechano-transduction pathways regulating YAP/TAZ activity LATS1 MOB1A MOBKL1A LATS2 NF2 PMC8334851__F2 Impacts of Immunometabolism on Male Reproduction CD40 CD80 FOXP3 TNF PMC3331705__F1 Tumor suppressors and oncogenes in the Wnt pathway BCL9 PORCN APC LRP5 TANK LRP6 PMC3701596__F3 Sleep specific effects on protein processing and the unfolded protein response VIP SVIP UBA2 COPE ATF4 HP PMC6789122__F7 Proposed model for the role of RarA in adrenocortical development RARA TCF3 CYP11B2 RXRA WNT4 VEGFA LEF1 CTNNB1 PMC5122440__F2 Sweet trap in tumors: aerobic glycolysis and potential targets for therapy TSC2 TSC1 HEL-S-133P PTEN TIGAR MTOR PMC3613825__F8 Proposed model of regulation of pro-apoptotic signaling pathway by miR-128 IGFBP5 MDM2 SIRT1 PMC3775871__F1 Epigenetic Regulation of SOX9 by the NFKB Signaling Pathway in Pancreatic Cancer Stem Cells CD40 EGF LTA TGFA TIRAP RELB TAB3 HEL-S-71 NGF MAP3K7IP1 PLCG2 RELA CP PMC3636549__F2 HEDGEHOG SIGNALING IN CHOLANGIOCYTES HHIP SMO PMC4746688__F8 A Novel Pathway for Triacylglycerol Biosynthesis Is Responsible for the Accumulation of Massive Quantities of Glycerolipids in the Surface Wax of Bayberry (Myrica pensylvanica) Fruit LPA PAH PMC9534503__F6 Species unique MEGENA modules ZCCHC8 IQCC NT5DC2 ZNF74 FGD2 MYBL2 ECT2 CTSS B2M TUBB ANXA11 FANCE RBM34 KPNA2 MCM10 HLA-G SPNS1 HEL-S-166mP VAT1 AKT1S1 VPS39 HCTP4 PMC6534790__F2 Coagulation factors and their connection to monocyte activation VWF GP1BA F2 PMC7230958__F1 Summary of the metabolic pathway for n-6 and n-3 polyunsaturated fatty acids GLA TNLG7C ADA PMC11769975__F2 Fusobacterium nucleatum reshapes the tumor milieu in CRC cells and immune cells [This figure was created using MedPeer (www EGF TIGIT CCL3 ARG1 CXCL2 TNF PMC11769975__F1 Mechanisms by which Fusobacterium nucleatum may contribute to colorectal carcinogenesis [This figure was created using MedPeer (www PAK1 TLR4 WNT7A PTEN WNT9A WNT7B MYC TNF CCND1 CTNNB1 MYD88 PMC6337850__F6 A working model: N-Myc differentially regulating miR-421/ATM pathway contributes to ADT resistance and Enzalutamide resistance development of prostate cancer ELL ATM EZH2 PMC6823248__F5 HDAC6 inhibition repressed B cell signaling pathways in NZB/NZW mice CD40 CD81 JUN CD180 IL4 BLNK PTEN FOS BLK DAPP1 FYN BCL10 TLR4 LYN CREB1 PMC9687725__F6 Comparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media CANX MAK PMC5733345__F1 Principal pathways of cell death RIPK3 BAX BAD MLKL RIPK1 IL1B FADD PMC12204001__F1 Molecular mechanisms of cGAS-STING pathway activation TBK1 CGAS IRF3 PMC11769975__F5 Apoptotic effect and immune invasion of Porphyromonas gingivalis in OSCC [This figure was created using MedPeer (www STAT3 BAX BAD NLRP3 PMC12204001__F3 Protumor role of cGAS-STING pathway TBK1 CGAS IRF3 PMC4139969__F3 Role and targeting of Aurora kinases in head and neck cancer AURKA ZW10 KLHL9 PMF1 CENPE MYLK CLASP1 FOXM1 C13orf34 SMC2 PPP2R5D SMC4 TBL3 TDRD7 NUP107 NSUN2 ANKZF1 KLHL13 BRCA1 AURKB PAK1 NFKBIA AJUBA MBD3 HCTP4 NCL PMC12204001__F2 Anti-tumor role of cGAS-STING pathway CXCL11 CGAS PTMS MICA MICB CXCL10 PMC11769975__F3 Possible molecular mechanisms of Fusobacterium nucleatum in tumor progression [This figure was created using MedPeer (www RIPK2 NLRP3 TLR4 CTNNB1 BIRC3 PMC8460903__F5 Mechanotransduction Regulates Reprogramming Enhancement in Adherent 3D Keratocyte Cultures SMAD1 DKFZp781O1323 SMAD2 RHO PMC3750319__F2 Canonical, non-canonical and the atypical NFKB signaling pathway CD40 ATM TNF PMC8502110__F5 MiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in Gamma-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease ARHGEF12 BCAT1 PTEN ARHA MTOR PMC9687725__F3 Comparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media CAMK2A MYH2 PMC8647069__F8 COVID-19 with obliterating endothelialitis associated with complement activation and accumulation of C5aR1-expressing macrophages around vessels CD163 ACE2 CD68 PMC9687725__F2 Comparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media GPR171 EGF GIP BOK RRAS MMP9 GNG7 PMC3750319__F5 Crosstalk of the canonical NFKB pathway with other signaling processes STAT3 RELA IL6 VCAM1 ERG CYLD PMC2772702__F6 The PI3k/Akt signaling pathway depicting the possible sites of action by the PI3k inhibitors LY294002 and wortmannin and the Akt inhibitors Akt-VIII, Akt-V, and Akt-IV C2 MTOR PMC5908099__F4 Signalling interaction of the death receptor pathway and mitochondrial pathway PYGL PIG59 CPD PMC7958858__F2 Signaling pathways involved in TJ formation and modulation EGFR RELA CD14 IRAK1 ATF2 ARHA GRB2 TRAF6 IRAK4 PMC8285369__F1 Melatonin interferes with COVID-19 at several distinct ROS-related steps IL6 TNF MPO PMC4450212__F4 Significant signaling pathway networks mined from phosphotyrosine-containing proteins in a glioblastoma tissue PLEK2 SYNGR3 MRPS33 DNAJC25 EFR3A SPATA2L RBM12B CHI3L2 CEP85 CEP192 LDHAL6A HPS1 DCHS1 PSD3 HOXA1 HEL25 RNASE7 PXMP2 ACTBL2 LDHB PLXND1 HEXA PTPRS ZNF569 ARAP1 NLRC3 RAB37 GPR176 ENO1 PS1TP5BP1 PMC11865073__F5 Neuroinflammation signaling pathway activity and member DEGs from mThy1-Alpha-synuclein overexpression at 10 months CD40 TH CD80 TBK1 SYK FAS PYCARD TIRAP GSK3B GABBR2 CCL5 CCL2 CTNNB1 MYD88 TREM2 HMOX1 IFNG IL1R1 NTF3 TYROBP CX3CR1 CX3CL1 IRAK3 IL18 WNT1 FZD1 BIRC3 IDE HMGB1 ACVR2B GDNF TICAM2 SNCA IL4 IRF3 PTGS2 MMP9 IL6 TNF GJB1 BCL2 RET CYBB PMC6381083__F9 Canonical and non-canonical NFKB pathway CD40 LTBR RELA RELB TRAF3 TRAF2 MYD88 PMC11865073__F3 Neuroinflammation signaling pathway activity and member DEGs from mThy1-Alpha-synuclein overexpression at 7 months CD40 SYK GRIN2B CXCL12 PYCARD CREB5 GABRB2 GSK3B BACE1 CCL5 TRAF3 CCL2 IRAK4 CTNNB1 GABRB1 HMOX1 IFNG NGF ACVR1B NTF3 CX3CR1 SLC6A11 CX3CL1 IL18 WNT1 MMP3 TLR7 CRP IDE HMGB1 IL10 TICAM2 SNCA IL4 IRF3 IRF7 PTGS2 MMP9 TNF CXCL10 GJB1 NFE2L2 BCL2 PMC6162708__F1 Canonical and DNA damage-induced NFKB signalling pathways ZAP70 ATR TRADD BCL10 BCR BTC BLNK ATM TRAF6 PMC3575708__F8 Model for Ctip2 functions in the proliferation and differentiation of epidermal keratinocytes EGF EGFR NOTCH1 PMC2574996__F15 Our difficulty in suppressing epimerization at the bis-benzylic stereocenter bearing the ester in the azide displacement led us to pursue an alternate route to amurensinine via intermediates with attenuated acidity at the bis-benzylic carbon () ATM CS PMC2574996__F12 We then examined the Pd-catalyzed oxidative kinetic resolution of hydroxyester (±)-15 ATM CS PMC4754450__F1 Abbreviated pathway for the biosynthesis and metabolism of Orn in plants in connection to polyamines, amino acids, TCA cycle metabolites, and alkaloids NAGS OTC NAGK PRODH DAO PMC7310007__F2 cGAS-STING pathway TBK1 CGAS IRF3 PMC11121637__F1 Schematic representation illustrates the role of miRNAs in the regulation of FOSL1 FOSL1 PMC2948329__F2 TSC1/2 integrates multiple signals to control cell growth and proliferation RHEB TSC1 CDK2 PMC11121637__F4 FOSL1 in promoting drug resistance and radio resistance ITGB4 FOSL1 DUSP7 PMC5989100__F2 Major signalling pathways involved in the control of skeletal muscle hypertrophy and mitochondrial biogenesis RHEB TSC2 TSC1 IGF1 MTOR PMC4848843__F2 Regulation of lipid metabolism by BAF60a and BAF60c in periportal and perivenous hepatocytes, respectively, under the control of nutritional and hormonal signals FAS NR1C1 USF1 SIRT1 PMC7330533__F2 Network pharmacology of targets of anemoside B4 against pneumonia CASP9 TGFB1 CASP8 NFKB1 CASP3 TNF PMC7330533__F8 Schematic of anemoside B4’s anti-inflammatory mechanism IL16 TLR4 MYD88 PMC8120178__F2 Phytochemicals in Chemoprevention: A Cost-Effective Complementary Approach BAD GSK3B MDM2 MTOR PMC10669348__F3 Schematic and simplified overview of the intracellular transduction cascades induced by 5-HT2AR TrkB and Sig-1R receptor activation by psychedelics GRB2 MTOR BDNF PMC8661100__F3 Evidence of myomiR regulation of the pentose phosphate pathway during mechanical load‐induced hypertrophy MTHFD2 MTHFD1 PHGDH SLC38A1 SHMT1 PSAT1 SFXN1 HEL-S-51e PSPH PMC10142331__F2 SFTSV mediates cell cycle, apoptosis, and the cGAS-STING pathway to achieve immune escape MAX CDC2 TBK1 CGAS PMC10142331__F1 Mechanisms by which SFTS inhibits key immune signalling pathways and promotes inflammation BAX MAVS NLRP3 TRIM25 STAT2 IRF9 IRF3 IRF7 TRIM21 PMC4499842__F7 UCB-MSC therapy is curative for IC bladder EGF FGF16 IGF2 PMC11606877__F3 Anticancer role of RES against NMSC: Focusing on oxidative stress, cellular, and molecular mechanisms TNF CTNNB1 PMC8617551__F2 Antagonism of interferon signalling by SARS-CoV-2 and related coronaviruses TBK1 JUN MAVS RNASEL IRF3 IRF7 ATF2 TRAF6 STAT1 TRIM25 IFNAR2 IFNAR1 JAK1 TYK2 PMC7299535__F7 Increased CHST15 follows decline in arylsulfatase B (ARSB) and disinhibition of non-canonical WNT signaling: potential impact on epithelial and mesenchymal identity DKK3 GALNS GATA3 PMC6005202__F2 Towards a sustainable bio-based economy: Redirecting primary metabolism to new products with plant synthetic biology C6 HEL-S-62p PMC4442140__F3 Results from validation screens for Listeria infection RPL8 CDC42 RAB10 ARPC2 PIK3R1 BACE1 FGD4 MTOR MYC ARHGEF9 PI3 COPB2 CLTA MYL2 TRAT1 TLN1 CLTC HEL-S-15 RSPO4 VIP PDLIM7 LIMK2 PERP LIMK1 MYO6 ARHA NCKAP1 FURIN RAC1 RPL35A CBL ACTR3 ITGB1 CYFIP1 FAU DIAPH2 RAB35 GRB2 OCRL PMC3635523__F7 Schematic model put forward the potential role of P4HB at different GBM cell states to TMZ treatment BAX ATF4 EIF2A PMC9589302__F6 Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR 4/NFKB pathway and protecting the intestinal barrier TLR4 IRAK1 IRAK4 PMC5850280__F1 Wnt activity is necessary for heart development and becomes very low in the adult heart MSC WIF1 CTNNB1 PMC9107641__F2 Metabolic engineering of Clostridium ljungdahlii for the production of hexanol and butanol from CO2 and H2 POR COCH CCAR1 HBD PMC6984455__F1 Brief mechanisms of Ub-dependent and Ub-independent mitophagy ATG16L1 BNIP3 PARK2 BNIP3L BCL2L13 PMC4550852__F7 FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes AOX1 FABP4 MTOR PMC3023586__F1 Host-cell signalling induced by EPEC Tir TEC FYN RAC1 PMC9021824__F5 miR-1908 Dysregulation in Human Cancers TGFBI SMAD2 LDLR SMAD4 SKI PMC9021824__F2 miR-1908 Dysregulation in Human Cancers JUND SFRS3 PTEN NKIRAS2 MEF2C PMC1951772__F8 PI3K activation by eIF2A kinases RICTOR MTOR EIF2A EIF4E PMC7217141__F2 Summary of the processes thought to be involved in thoracic aortopathy development MYLK FBN1 TIMP1 COL3A1 PRKG1 PMC3490280__F2 Recipient T-lymphocytes govern Mesenchymal stem cell (MSC)-based bone regeneration via IFNG and TNFA FAS SMAD6 MSC RUNX2 PMC7912581__F8 Complex mechanism of FASIS and (B) GPR40 receptor part VIP PYY ORAI1 STIM1 TRPC1 GPR119 GIP NOX4 SIRT3 TG TRPM2 KY TRPM5 TRPC3 PMC4893201__F1 Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes NAMPT HEL-S-26 SIRT1 SIRT6 PMC2543934__F5 PPARG in Type 1/Type 2 T (NK) cell differentiation STAT1 IFNGR2 IL4 STAT4 GATA3 PMC11669335__F3 Canonical and non-canonical inflammasome pathways in pyroptosis GSDMD NLRP3 IL1B PMC5440090__F2 Anti-tumor immune response through CTLA-4 and PD-1 pathway blockade, and T-cell signaling in the treatment of melanoma HEL-S-92n MTCL1 PMC11669335__F2 Extrinsic and intrinsic apoptotic pathways BAX APAF1 FADD PMC7117992__F2 Key longevity-regulating pathway proteins whose functions may be altered or enhanced by differential PTMs/proteoforms in long-lived species TSC2 TSC1 INSR MTOR ATG5 SIRT1 PARP1 SIRT6 PMC9315936__F4 JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies TSLP CRLF2 PMC7912581__F2 New paradigm in the mechanism of GSIS in the context of the regulation of insulin secretion VIP GLP1R PYY ORAI1 STIM1 TRPC1 GIP ME1 NOX4 SST TRPM2 KY TRPM5 PC SNAP25 HEL-S-26 PMC8923340__F3 COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines TMPRSS2 CXCL9 TBK1 NRP1 IRF3 IRF7 TRAF3 FURIN TRAF6 CXCL8 MYD88 MAP3K7IP1 RIGI TLR3 IRAK3 TLR8 TLR7 ACE2 PMC7829997__F2 Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay IDO1 AHR PMC11669335__F5 Classical autophagy pathway ATG101 ATG10 ATG3 ATG16L1 ATG12 ULK1 PMC11669335__F4 Necroptosis pathway RIPK3 TRADD MLKL RIPK1 TNF TRAF2 FADD PMC3778193__F6 Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and NFKB activation TLR4 BMP2 NOTCH1 PMC8471547__F6 SMAD4 Feedback Activates the Canonical TGFB Family Signaling Pathways TF TGFBR2 BMPR2 SP1 ACVR1B SMAD4 CREB1 PMC3141288__F3 Roles of NFKB-mediated inflammatory pathway in cellular transformation, cancer survival, proliferation, invasion, angiogenesis and metastasis COX2 VCAM1 CXCR4 TNF CCND1 PMC3691323__F6 Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain CDC2 APC INCENP AKAP8 HEL-S-66 PMC8431051__F2 Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer CSF1 IDO1 PTEN ERG FOXP3 CCL2 CXCL8 IMPACT PMC8238692__F1 Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress CD69 TLR4 NOD2 CXCR4 CTNNB1 PMC7779530__F2 TGFB signaling SMAD2 SMAD4 HEL-S-28 PMC6161786__F2 Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy MAP3K7IP1 IRAK1 TRAF6 PMC6721808__F7 Simplified model of fatty acid (FA) metabolism CD36 FASN PML PMC4977549__F1 ‘Atherothrombosis-associated microRNAs in Antiphospholipid syndrome and Systemic Lupus Erythematosus patients’ SOCS1 GNAI3 STAT3 RAF1 CCR2 CYCS GSK3B IRAK2 ITGAV MYD88 MAPK14 GNAS TNFRSF18 STAT1 BCL10 F2 TLR4 NRAS CHUK MAPKAPK2 NFATC1 COL11A2 ARHA ITGB3 FURIN KRAS FOS CBL RELA MAPK7 BCL2 NFATC3 TNFRSF11B LBP PMC11831195__F3 Molecular docking of PD and targets STAT3 HMOX1 MMP3 PTGS2 PMC6721808__F1 Simplified scheme of the cellular metabolism pathways important for AML pathophysiology C2 SLC7A5 MTOR PMC7281175__F2 Metabolic pathways in hepatocarcinogenesis ACLY CYP8B1 GPX4 FACL4 HSD3B7 ABAT TG HMGCR SUCLA2 BAAT MVD DHCR7 CYP7B1 HEL-S-64p CYP27A1 PMC11591849__F3 The diverse mechanisms through which anti-diabetic pharmacotherapy may affect tumor microenvironment dynamics STAT3 NLRP3 CXCL10 CCL2 CXCL8 PMC11591849__F1 Impact of metformin on cancer-related signaling pathways via AMPK activation TSC2 ULK1 GSK3B IGF1R MTOR CCND1 IRS1 PMC8263695__F1 Targeting the eicosanoid pathway in hepatocellular carcinoma COX1 COX2 PMC10389832__F1 CGAS-STING in Age-Related Diseases from Mechanisms to Therapies TBK1 CGAS IRF3 PMC6141902__F1 The two commonly activated pathways and genetic aberrations involved in thyroid cancer, as well as the targeted therapies studied in thyroid cancer ALK NF1 EGFR TERT PTEN MTOR RET PMC8382522__F9 Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/Beta-Catenin Signaling Pathway APC TNF IL1B CTNNB1 PMC7177281__F1 Neurotrophins and their effect on angiogenesis and neurogenesis in the skin IGF2R EGF NGF IGF1 EGFR IGF1R BDNF IGF2 PMC10389832__F4 CGAS-STING in Age-Related Diseases from Mechanisms to Therapies STAT3 IRF3 TREX1 ENPP1 PARP1 PMC7729630__F5 Schematic model illustrating an effect of PEA on CORT-induced depression-like mice model CORT SYP TAAR1 BDNF PMC6836709__F9 Pathways to autoimmunity and autoinflammation in ABIN1[D485N] mice TK1 AK1 IRAK1 TLR7 IRAK4 MYD88 PMC5855695__F1 MicroRNA biosynthesis pathway AGO4 DGCR8 AGO1 AGO2 DROSHA PMC6292306__F2 Serotonin directly increases PTHrP synthesis in the mammary gland and indirectly through regulation of the Hedgehog signaling pathway CASR ORAI1 SHH PMC4671741__F5 Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension CTRL PAH MTR HEL-75 PMC6292306__F1 Calcium movement into the mammary gland regulates maternal calcium homeostasis during lactation CASR ORAI1 PTH1R PMC8593415__F8 Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target TTF2 VLDLR MYH7 RBM20 LMO1 TYMS MTOR SMC2 RRAS2 PMC3731598__F1 An immune synapse and downstream events CD40 CD27 TNLG8A BTLA CTLA4 LAG3 PMC11352355__F2 Cell functions of K6, K16, and K17 IFNG STAT3 HMGN2 STAT1 IF2B1 H2AX EGFR KRT16 AIRE MTOR PMC11040904__F2 Regulatory pathways governing PD-L1 via phosphorylation and ubiquitination EGF CASP8 TNFAIP3 LRRK2 IFIT1 APC C7orf21 HUWE1 STUB1 RNF125 CDK6 SPOP USP2 MIB2 STT3A CMTM6 JAK1 CMTM4 CDK4 PMC11040904__F4 Regulatory pathways of PD-L1 via deubiquitination USP51 USP2 APC USP18 USP22 USP20 USP9X TINCR HEL-117 PMC11040904__F3 Negative regulatory pathways of PD-L1 mediated by other posttranslational modifications UFL1 MMP7 ING4 UFM1 APC ISG15 MMP9 SETD7 PMC3831322__F5 Scheme illustrating potential mechanisms by which nandrolone reduces bone loss after SCI FZD5 ENC1 WNT3A LRP5 RUNX2 PMC11040904__F6 Positive regulatory pathways of PD-L1 mediated by other posttranslational modifications PDIA5 EGF APC FASN ARF6 ZDHHC9 HDAC2 ZDHHC3 PMC11040904__F5 Emerging therapeutic frontiers in cancer: insights into posttranslational modifications of PD-1/PD-L1 and regulatory pathways FAT4 EGF B4GALT1 APC C7orf21 STT3A SEC61G GLT1D1 B3GNT3 CTNNB1 PMC5403977__F12 EGF and GLP-2 signaling to attenuate mucosal atrophy in a mouse TPN model EGF IGF1 CCND1 PMC11040904__F7 Posttranslational modification of PD-1 FUT8 MDM2 CISH FBXO38 LCK EIF4E PMC8960869__F8 Mechanism by which HORMAD1 functions to promote the malignant phenotypes of lung cancer cells MMP7 APC MMP9 CCND1 LEF1 CTNNB1 PMC6600647__F4 Uncovering the assembly pathway of human ribosomes and its emerging links to disease RRS1 RPL5 RPL11 PMC9504097__F2 Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure TJP1 NLRP3 IL18 PMC3820966__F1 Cellular response to oxidative stress mediating by Beta-adrenergic response and sirtuins involvement ADRBK1 BAX GADD45A PMC9266407__F3 Evaluation of Adverse Effects of Resorbable Hyaluronic Acid Fillers: Determination of Macrophage Responses COCH ANAPC2 MYC PMC11586797__F1 Mammalian target of rapamycin signaling pathway and its interaction with EZH2 expression in hepatocellular carcinoma: Mechanisms and implications EZH2 PTEN MTOR PMC7859916__F2 Role of Eps8 in the regulation of the malignant phenotype of a tumour STAT3 EGF FOXM1 EGFR GSK3B GRB2 MTOR SRC CCND1 PMC3783819__F3 Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction STAT3 EGF HGF EGFR SMAD2 CXCL1 IGF1R MYC CTNNB1 CD44 IGF1 RELA MMP2 GRB2 GAB2 CCND1 PMC3783819__F2 Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction JUN GRB2 MTOR FOS PMC9238060__F2 Epigenetic modifications in drug resistance and treatment of breast cancer ME3 TDG PMC9238060__F1 Epigenetic modifications in drug resistance and treatment of breast cancer EGFR SMAD2 APC SMAD4 CTNNB1 PMC6299639__F2 Mechanism of HSV evades host immune responses TBK1 MAVS HEL-S-62p RNASEL IRF3 IFI16 TRAF3 TRAF6 RAC1 MYD88 STAT1 TLR3 EIF2A PMC7585181__F2 Participation of SUMOylation in molecular signalling pathways involved in atherosclerosis NR1C1 RELA SENP2 PMC8397972__F4 Convergent Functional Genomics Analysis to Identify Biological Regulators Mediating Effects of Creatine Supplementation MAX SUZ12 SP1 TXNIP ZMIZ1 FHL2 EZH2 MTOR MYC FOS IGF1 PI3 NFYA OSR1 GRB2 PIKFYVE PMC3736728__F2 Folate, Alcohol, and Liver Disease HEL-S-61p PMC11640331__F1 Radiation, Immunotherapy, and Chemotherapy in the Management of Locally Advanced or Metastatic Cutaneous Malignancies SUFU PTCH1 SMO GLI3 PMC6829497__F1 Canonical Wnt ligands induce two mutually exclusive Dvl2- and Fyn-dependent arms STAT3 WNT3A LRP5 LRP6 SRC PMC6274068__F1 Capsaicin mediates saliva secretion via transient receptor potential vanilloid subtype 1 (TRPV1) CLDN3 TRPV1 AQP5 PMC8951683__F9 Effect of mitochondrial fusion on chondrogenic differentiation of cartilage progenitor/stem cells via Notch2 signal pathway ACAN SMS SOX9 HES1 CTNNB1 PMC8649804__F7 Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling TF SMAD1 DKFZp781O1323 IGF1 SMAD2 SMAD4 RUNX2 PMC11941340__F1 Interaction of the WNT pathway, Hippo pathway, and Notch pathway WWC3 APC GSK3B LRP5 LRP6 TEAD4 CTNNB1 LATS1 LATS2 TEAD2 TEAD3 WWC1 AXIN1 WWC2 MB PMC8066746__F3 Schematic model of “Common Pathways Underlying Drug dependence” is an output (FDR p < 0.01) of the Wikipathway functional pathway analysis GRIA3 GRIA2 RAF1 PRKCB ARAF DRD1 DRD2 DRD4 PRKACG RAP1A CAMK4 ADCY1 GRIA4 CREB1 PS1TP5BP1 PMC6204183__F3 Neuropeptide signalling pathway (GO:0007218) enriched by genes that showed higher expression level in the hypothalamus of 3-week-old than 6-week-old cockerels PMCH CGA NMB POMC GHRH NMU NPY PMC7771963__F1 Interconversion of phosphoinositides in eukaryotic cells FIG4 PI3 PTEN INPP5E OCRL PMC3092273__F1 Complementary signaling pathways activated in human cancer cells RHEB TSC2 TSC1 IGF1 PTEN MTOR MYC PMC11669362__F6 Activation profile of the Growth hormone signaling pathway (gene expression via SRF, ELK1, STAT5B, CEBPD, STAT1, STAT3) in the experimental NSCLC groups of RECIST responders (A) and non-responders (B) to PD(L)1 ICI immunotherapy PTPN6 GHR CEBPB IRS1 PMC4778065__F9 Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases HDAC5 PMC11669362__F8 Activation profile of the Interleukin 10 signaling pathway in the experimental NSCLC groups of RECIST responders (A) and non-responders (B) to PD(L)1 ICI immunotherapy ZFP36 IL10 TLR4 CD14 SOCS3 TYK2 TIA1 PMC2907165__F1 Type I IFN Signaling IFNAR2 IRF9 IFNAR1 CRKL VAV1 MTOR JAK1 RAC1 TYK2 IRS1 PMC10820555__F3 Study on the Pharmacological Mechanism of Icariin for the Treatment of Alzheimer’s Disease Based on Network Pharmacology and Molecular Docking Techniques STAT3 TFRC HEL-S-133P TLR4 HEL-S-162eP EPO PFKL HEL-S-87p DAO BIK PMC5783486__F4 Network of differentially expressed proteins in KD with CAD and CAA SERPIND1 HEL-S-62p VTN C4A ALB LPA APOH CLU F2 C9 A2M C4B_2 PROC KNG1 SRGN SERPINC1 SERPING1 F13B APOE SERPINA1 CFH PLG IGFALS HRG HEL-S-78p SET APOA2 MBL2 HPR GUGU APOB PLTP FGA PMC6322547__F1 Transcriptomic analysis of axon guidance signaling pathways in liver fibrogenesis CDC42 CXCL12 DCC BOC BMP7 HEL-S-28 RYK ARHA SLIT1 ROBO2 NEK1 gdf7 FYN RAD1 SLIT2 RHOD PTCH1 SHH FES SMO RND1 SEMA7A PMC3430210__F1 TRAIL signaling pathway and mechanisms of TRAIL resistance BAX FADD PMC7458154__F2 Three Examples of Metabolic Transitions Influencing the Activation of Transcriptional Programs That Have an Instrumental Effect on Cell Fate Transitions SMAD2 CTNNB1 PMC7397164__F1 Canonical and non-canonical Wnt signaling pathways CDC42 APC LRP5 LRP6 RYK ARHA NLK RAC1 DAAM1 PMC7458154__F1 Connections of Metabolic Pathways with PTM Reactions through Intermediate Metabolites and Impact of Growth Factor Signaling on Modulation of Glucose Metabolism TSC2 TSC1 FOXO1 HIF1A MYC PMC8232639__F1 Insulin in Health and Disease: An Update TSC2 BAD TSC1 GRB2 EIF4E PMC7817532__F2 Toxoplasma and Eimeria co-opt the host cFos expression for intracellular development in mammalian cells GRIA3 JUN ATP2B1 CREB5 PIK3R3 PIK3R1 ATP1A1 GHRL ARHA RHO TNF FOS CAMK2D ADRB2 CFTR EP300 BDNF GRIA4 RRAS2 GLI3 PMC5035631__F1 Sweet path to metabolic demise: fructose and lipid synthesis KHK ALDOB MTTP GYS2 FASN GCK ACACA PKLR PMC1952636__F9 Beta-Arrestin–mediated B1-adrenergic receptor transactivation of the EGFR confers cardioprotection HBEGF EGFR SRC PMC5452883__F1 Intratumoral synthesis of E2 and its inactivation by sulfate conjugation from circulating steroid hormone precursors in cancer cells HSD17B1 HSD17B2 SULT1E1 STS PMC6959903__F6 MiRNA-mRNA regulatory networks in adenoid cystic carcinoma (ACC) CDC2 CENPF TOP2A PMC8714803__F7 Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic TH TNK2 JUN ABCC1 MAP3K10 ATP13A1 AGAP2 FASN ACD ADRBK1 TSC2 ICE1 RUTBC1 SCRIB MED25 PMC8832142__F1 Interaction Between Intracellular Energy Metabolism and Signaling Pathways During Osteogenesis GLS HEL-S-133P ND4 PTH VHL PMC8832142__F2 Interaction Between Intracellular Energy Metabolism and Signaling Pathways During Osteogenesis OGA OGT GLS HEL-S-133P MTOR RUNX2 CTNNB1 PMC3557298__F4 mRNA-seq Analysis of the Gossypium arboreum transcriptome Reveals Tissue Selective Signaling in Response to Water Stress during Seedling Stage TF BIN2 EBF2 BAK1 PMC3994912__F2 Can Transcriptomics Provide Insight into the Chemopreventive Mechanisms of Complex Mixtures of Phytochemicals in Humans? PAX3 BAX TRAF3 TRAF6 MAPK14 IFNG SUMO1 PDPK1 TICAM1 TLR4 BMF ATF4 TRAF2 DIABLO FADD PMC7662794__F1 Risk factors/loci and associated cellular processes identified by genome wide association studies (GWAS) involved in Alzheimer’s Disease (AD) converge to the proteostasis network CLU SORL1 CD33 PSEN2 BIN1 APP ADAM10 PSEN1 EPHA1 CR1 PICALM PMC3104565__F1 Simplified diagrams for agrin-induced signaling MUSK LRP4 FYN PMC6235774__F1 Signaling reactions induced by thrombopoietin POR HRAS TEC GAA MPL CRK PRKCE BRAF HEL-S-11 MTOR THPO KRAS PMC3838875__F4 Cancer Cells Incorporate and Remodel Exogenous Palmitate into Structural and Oncogenic Signaling Lipids LPA HEL-S-5 PC PMC2613484__F3 Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways LTBR RELB VCAM1 PMC4972037__F1 Understanding Extranuclear (Nongenomic) Androgen Signaling: What a frog oocyte can tell us about human biology PELP1 MOS EGFR SRC PMC1937523__F3 Comparison between the gene expression profiles and predicted substrate uptake rates MAL PTS DLD GIP GALP CIT PMC8605121__F2 Dysfunction of miR‐802 in tumors RAN SUFU EGFR APC FGFR1 SMO PTEN RAB23 ZNF521 MTOR CTNNB1 PMC8605121__F1 Dysfunction of miR‐802 in tumors NKD1 CDH2 SRSF9 UBN2 RAN MMP21 BTF3 PTEN FLOT2 TCF4 MTOR MYLIP RUNX3 CTNNB1 FOXM1 ARPP19 TCF7L2 MAP2K4 GC PC RAB23 ZNF521 CYLD YWHAZ PMC6469084__F7 Relationship between USP6NL and the pathway USP6NL CCND1 CTNNB1 PMC2613484__F7 Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways LTBR RELB BTLA PMC8551324__F8 NRIP1 is activated by C-JUN/C-FOS and activates the expression of PGR, ESR1 and CCND1 in luminal A breast cancer ERBB3 HRAS STAT3 HBEGF RAI1 EGFR ERBB2 CDK2 GRB2 JAK1 CTNNB1 PMC10920326__F2 Differential cellular components within the bone marrow microenvironment involved in immune evasion of MM CD40 CD14 S100A9 FGF2 PMC8971914__F1 Interactions of circRNAs with methylation: An important aspect of circRNA biogenesis and function ZNF609 YTHDC1 YTHDF2 AAG1 YTHDF1 METTL3 PMC6584587__F5 Pathway map for “LRRK2 in neurons in Parkinson’s disease” LRRK2 GSK3B AP2A1 HEL70 CS RAC1 PS1TP5BP1 RDX PMC2788512__F7 Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway LMX1B LMX1A MSX1 OTX2 PITX3 SHH WNT1 FOXA2 PMC9288030__F2 Noncoding RNAs as sensors of tumor microenvironmental stress TNF IL1B PMC3047785__F5 CD28 signaling events CDC42 BAD VAV1 GRB2 MTOR FLNA RAC1 LCK PMC9632440__F7 Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer’s disease BAX JUN BAD GSK3B BCL2 IL6 PTGS2 TNF PMC7601648__F2 Non-canonical NFKB signalling pathway and the role of ubiquitination CD40 ZFP91 OTUD7B RELB TRAF3 TRAF2 PMC2918459__F1 Biosynthetic pathway of ω3 and ω6 polyunsaturated fatty acids (PUFAs) ELOVL2 FAS COX1 COX2 FADS2 FADS1 PMC8930976__F2 Queueing theory model of pentose phosphate pathway RPE HEL-S-304 PMC4885105__F2 Infection cycle of HCV CD81 NPC1L1 EGFR LDLR CLDN1 PMC5145800__F1 Astrocytes and neuronal activity play distinct, cooperative roles in neuronal redox homeostasis TXN KEAP1 GCLM GCLC MAF GCK HEL-75 PMC8074089__F4 Rho Family GTPases and Rho GEFs in Glucose Homeostasis GRB10 PTEN RAC1 IRS1 PMC1819569__F6 The signalling pathways involved in Pam3Cys-induced degranulation and cytokine/chemokine production in human LAD 2, MLMC and BMMC TLR1 CCL2 PMC2658783__F2 The erbB family and the IGF/IGF-1R system TGFA IGF1 IGF1R IGF2 PMC4139483__F1 An Unexpected Journey: Lysine Methylation Across the Proteome SMYD2 RELA SETD6 PMC7044062__F8 Changes in the urea cycle following LPS stimulation with or without DCA pretreatment ASL ADM OTC PMC8599256__F2 Endogenous estrogens—breast cancer and chemoprevention CYP1A2 CYP1B1 CYP1A1 PMC11989623__F2 Main mechanisms of resistance to ET and/or CDK4/6is in advanced ER+/HER2− breast cancer TF AURKA ATR EGFR BRCA2 SMAD4 PTEN MTOR LATS1 RB1 LATS2 CDK6 BRCA1 NF1 CHEK2 CDK2 ATM CDK4 PMC11989623__F1 Complexity of the molecular pathways governing the function of the cyclin-dependent kinases (CDKs) through the cell-division cycle CDC2 CDK6 CDK2 MYC CDK4 PMC9405369__F1 Clinical Research Progress of Small Molecule Compounds Targeting Nrf2 for Treating Inflammation-Related Diseases HMOX1 KEAP1 GCLM NQO1 MAF PMC9456568__F2 NAD/NAMPT and mTOR Pathways in Melanoma: Drivers of Drug Resistance and Prospective Therapeutic Targets CCR5 TLR4 BRAF MSC NAMPT PMC2715958__F2 One possible pathway which regulates cell migration in response to strain on fibronectin GSK3B SRC RAC1 PMC2715958__F1 One possible pathway which regulates cell proliferation in response to strain on collagen GSK3B SRC RAC1 PMC6163134__F2 Proposed signaling pathways in the development of hepatic portal hypertension HLF ARHA RHO PMC5733019__F8 GHK on pulmonary fibrosis IGF1 MMP9 BLM PMC5542379__F2 miR-206/133b Cluster: A Weapon against Lung Cancer? HEL107 GPD2 TRIB2 BCL2 SAMD3 PMC5542379__F1 miR-133b/206 Associates with Various Genes Mediating NSCLC Cell Migration and InvasionmiR-206 promoted lung cancer cell apoptosis by targeting c-Met and Bcl2, as well as governed EGFR, MET, and its downstream phosphorylation of ERK1/2 and AKT BCL2L2 SOX9 EGFR MCL1 BCL2 SAMD3 PMC5404780__F2 Mechanism of action of various Hedgehog pathway inhibitors TLR8 SMO TLR7 PMC9682161__F2 Prostaglandin E2 in neuroblastoma: Targeting synthesis or signaling? EGFR APC GSK3B LRP5 LRP6 GRB2 MTOR SRC CTNNB1 PMC5837124__F3 Various strategies to target Myc MAX AURKA BRD4 CDK7 MYC PLK1 CDK9 PMC8687853__F5 H2A.X Phosphorylation in Oxidative Stress and Risk Assessment in Plasma Medicine PPIC BAX BAD ATRIP CAD BCL2 SSB PMC11200984__F6 Action of Isoflavone Derived from Soy-Based Tempeh as an Antioxidant and Breast Cancer Inhibitor via Potential Upregulation of miR-7-5p: A Multimodal Analysis Integrating Pharmacoinformatics and Cellular Studies CDC2 STAT3 BAX ROS1 ABCC1 EGFR SMAD2 SMAD4 PTEN IGF1R MTOR PARP1 PMC5295490__F4 B3AR signaling activation in cardiomyocytes RYR2 PLN HEL-S-11 PMC6685439__F1 Cholesterol biosynthetic/protein prenylation pathway CDC42 IPP RHO PMC137069__F1 Hh-signaling pathway SUFU SMO RAB23 GAS1 PMC6627634__F1 Diagram showing the different molecular mechanisms of canonical nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome activation NLRP3 MLKL TNF FADD MYD88 PMC7778498__F1 Endosteal, reticular, and vascular niches in the context of bone marrow WNT10B IFNG CXCL12 DKK1 BMP2 PTH MB DKK2 IL1B PMC4052696__F9 Pathway Bridge Based Multiobjective Optimization Approach for Lurking Pathway Prediction SMAD2 SMAD4 OCIAD2 PMC11660123__F3 AIM2 in regulating the development of breast cancer and LUAD independent of inflammasome STAT3 BAX BAD AIM2 PMC6627634__F2 Diagram showing the different molecular mechanisms of non-canonical NLRP3 inflammasome activations SYK HMGB1 NLRP3 IL16 TLR4 IRF3 FADD MYD88 PMC11660123__F2 AIM2 regulation in CRC, HCC, and RCC in inflammasome-independent manner HLA-DRA MHC2TA AIM2 MTOR PMC4052696__F7 Based on experimental data GDS3634, miR-205 expression effect on prostate cancer cell line, from NCBI public database browser, P value of 8 samples of Student's t-test, microarray data was applied as the link cost for predicted paths JUP GNAS TGFA CDON PMC9003967__F11 Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGFB/SMAD3 signaling pathway CDH2 PCNA MMP2 CCND1 PMC6280921__F1 Cross-talk among different signaling pathways involved in MDSCs expansion, activation and function PTEN MYD88 PMC8356724__F1 The BMP-2 signaling pathway TF SMAD1 DKFZp781O1323 BMP2 SMAD4 PMC9374760__F1 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways STAT3 TBK1 RELB OTULIN TAB3 TANK IRAK1 IRAK2 TRAF3 PELI3 TRAF6 IRAK4 PELI1 MYD88 SHARPIN ELF4 STAT1 TLR4 IRAK3 RIPK1 CYLD ECSIT JUN CASP8 STAT2 IRF9 MAL CD14 IRF3 IRF7 FOS MAP3K7IP1 RELA TRAF1 LBP FADD PMC8430922__F3 Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases NGF ARHA PMC4172957__F6 Expression of genes in the canonical complement system pathway C6 HEL-S-62p CS C4A C4B_2 PMC4172957__F5 Expression of genes in the Th1 response network and interferon signaling pathway SOCS1 HRH1 IFNG HMGB1 PSMB8 MOG IRF9 PIK3R1 IFIT3 TYK2 MERTK PMC5130170__F1 Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway EGF EGFR GRB2 PMC9555085__F2 Current understanding of epigenetics role in melanoma treatment and resistance GDNF DAB2IP DACT3 EZH2 SETDB1 IGF1R CTNNB1 ME3 IGF1 IGFBP5 FOXO1 MLL2 ADRB2 SRC RET CP PMC8566418__F2 Estetrol and Mammary Gland: Friends or Foes? TF GREB1 TFF1 PGR HSPB8 SRC PMC4960006__F7 Diagram represents the proposed model of APC regulation of miR-17-92 cluster APC GSK3B PTEN TCF4 CTNNB1 PMC8898846__F4 Comprehensive Analysis of Immune Infiltrates of Ferroptosis-Related Long Noncoding RNA and Prediction of Colon Cancer Patient Prognoses BAX POLK GAS INA APC APP MYC FOS PMC9128303__F1 IGF-I structure and activity RPS6 TSC1 PTEN GRB2 MTOR PMC2953417__F1 REGULATION OF NITRIC OXIDE PRODUCTION IN HEALTH AND DISEASE ASL OTC PMC7327052__F3 Centrosome aberrations trigger an immunosuppressive microenvironment TBK1 CGAS ANGPTL4 APC PMC7327052__F2 Centrosome aberration-associated molecular pathways in cellular senescence PCM1 CEP192 PMC4693897__F8 Proposed mechanism for zinc‐mediated inhibition of interleukin‐1B (IL‐1B) signalling and its role for repression of human T helper type 17 (Th17) responses IL1R1 TRAF6 IRAK4 IL1B MYD88 PMC7790916__F1 Insulin resistance and exaggerated insulin sensitivity triggered by single-gene mutations in the insulin signaling pathway PDE3B GSK3B PTPN11 PTEN TBC1D4 PMC6608000__F8 EtOH metabolism pathway regulates KLF4 expression and function KLF4 MRC1 CYP2E1 ARG1 IL1B PMC3662904__F1 Transforming growth factor (TGF)B signaling cascade SMURF1 SMAD2 SMAD4 SKI PMC5536940__F1 Transduction of platinum-induced DNA damage: DNA repair or apoptosis BRCA1 BRCA2 ATM PALB2 PMC8569351__F2 FOXO1: a pivotal pioneer factor in oral squamous cell carcinoma RFWD2 SGK1 PRMT6 FOXO1 ATG14 MDM2 SIRT1 PMC9579336__F3 Synthesis, function, and regulation of sterol and nonsterol isoprenoids UBIAD1 HMGCR PPM2C PMC9579336__F2 Synthesis, function, and regulation of sterol and nonsterol isoprenoids RHEB TH UBIAD1 IPP HMGCR LDLR PMC9579336__F1 Synthesis, function, and regulation of sterol and nonsterol isoprenoids RAP2C RHEB HMGCR SQLE PPM2C ARHA RAP2B PMC9133562__F3 Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials PDGFRA PLG MTOR PMC9654076__F1 Molecular Targeting of the Most Functionally Complex Gene in Precision Oncology: p53 BAX ATR CDK6 MAK ATM MDM2 CDK4 PMC5580270__F4 Changes in hepatic gene expression associated with the PPARA signalling pathway and fatty acid metabolism between broilers (n = 6) and layers (n = 6) LPL ACLY CD36 FABP1 SCD FASN ACACA ME1 ACSL1 NR1C1 GPAM RXRA FADS6 HEL-S-32 ACADL PMC8525106__F4 Key radioresistance regulation models and marker genes identified by integrated transcriptome analysis in nasopharyngeal carcinoma RNF41 JUN TGFBI CASP2 PCNA TUBB4B MTA3 BRAF ATF2 THRA RANBP2 EIF4G1 PSMF1 FOXO4 BRCA1 CHEK1 CDK2 ATM SKP1 HEL-S-1 GADD45A CD3G YWHAG PMC9563254__F5 p21-Activated Kinase: Role in Gastrointestinal Cancer and Beyond STAT3 EGR1 SMAD2 SOX2 MYC CTNNB1 PMC8475945__F3 Unfolded Protein Response Pathway in PC3 (A) and ARCaP(M) (B) cells HEL-S-99n OS9 CANX EBP SP4 BCL2 AMFR ATF4 XBP1 VCP TRAF2 ERO1B PMC3486458__F7 AMPK/ERK/TSC2/mTOR signaling in PCV2-induced autophagy in PK-15 cells TSC2 RAF1 MTOR PMC3842585__F2 Mutations in the ERK/MAPK signaling pathway and related second messenger systems FGGY PLSCR5 JMJD1C GOLGB1 GSK3B IQUB GADD45A PMC5717006__F2 Mevalonate metabolism in immune and cancer cells IPP FAS CD36 MTOR MYC ABCA1 PMC9374760__F3 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways IFNE STAT3 LTA CCL18 TRIM32 IFNA13 IFNA14 CCL3 NFATC2 IFNA10 CCL15 SMAD2 OTULIN IL36A CCL5 CCL2 PIN1 IL-21 IFNG IF2D ATF1 CYLD CCL1 CEBPE CSF2 SP1 STAT2 RNF11 TNFSF6 AIM2 IRF3 IRF7 NLRP9 IFNA2 TNF FOS NAIP CEBPA NLRP7 CCL19 MUL1 TRAF1 CCL4 CCL20 IL15 IL19 CGAS TGFB1 MAVS IFNL3 ITCH MLKL TANK PELI3 CSF3 ELF4 IFNK SHARPIN TRIM55 MEX3C ZBP1 NLRP6 IL18 RIPK1 ATF4 IFNA1 CEBPB CCL17 ECSIT TRIM31 IF1IB1 IFNA17 JUN IFNLR1 IL12A CCL11 IFNL4 SCIMP IL13 MAL LIF CD14 IFNA4 TLR5 KITLG RIPK3 TLR1 IL24 TRIM25 TLR3 RELA LBP TRAF2 TYK2 TLR10 FADD PMC9374760__F2 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways CDC42 RGS2 RGS12 CXCL12 PIK3CA GNAO1 PIK3R5 PIK3R1 PTEN DOCK2 S1PR2 CX3CL1 RGS1 SRC INPP5D ARHA ARHGAP5 S1PR1 PREX1 RGS6 ELMO1 ARHGEF1 CXCR4 ARHGAP24 GNA13 OPN1SW PMC9374760__F4 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways PIK3CA PXN PIK3R1 PRKCZ MAPK8 DOCK2 DOK1 EZR FYN CFI PDPK1 PRKCA WAS PC ITK TMSB4X SRC PIKFYVE MAPK1 ND1 APC INPP5D HEL-S-28 PTK2B NCKAP1 PID1 DOCK1 BRK1 HEL114 ARHGAP5 CRK PREX1 CAPNS1 RGS6 PARD3 MAP3K1 ELMO1 RAPGEF1 ARHGEF4 ARHGEF1 CSK ARHGEF7 BCL2 WASF1 WASF2 GRB2 CXCR4 BAIAP2 ARHGAP24 GNA13 OPN1SW CDC42 ABI2 RGS2 RGS12 CXCL12 FERMT3 BAD GNAO1 PIK3R5 ZYX BRAF PTEN NCF1 CTNNB1 MYLK MAP2K4 S1PR2 CX3CL1 RGS1 ARHGEF2 JUN ARHA S1PR1 FOXO3A NFKB1 RELA RPS6KA3 MAP2K1 PMC8576142__F3 Myeloid dysregulation and therapeutic intervention in COVID-19 CCL3 CCL2 MYD88 PMC8389562__F5 Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer BRD4 USP28 CBL ZNF121 CTNNBIP1 MYC BPTF PMC8389562__F4 Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer LIN28B SPOP FUBP3 EZH2 MIF IGF2BP2 MYC PMC8389562__F3 Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer CIP2A OGT USP28 LIN28B ZNF121 LIN28A CUL4B MYC PRIMA1 PMC8476494__F8 Hypothalamic-pituitary adrenal-axis, toll-like receptors, and macrophage polarization in pre-atherosclerotic changes induced by social isolation stress in mice TLR4 VCAM1 PMC7378251__F3 Expression of genes related to starch and sucrose metabolism, glycolysis, TCA cycle and amino acids pathway under CK, MD, AT and SD ACLY DLD ASNS PMC4381956__F1 Complement in Monoclonal Antibody Therapy of Cancer C6 CD59 C7 HEL-S-62p C2 CFHR1 C9 VTN C4A C4B_2 CR1 IMPACT PMC1780025__F2 Heterogeneity of Pacemaking Ability among SCN Neurons Robust rhythm generation in SCN neurons CRY2 CRY1 PMC5527950__F2 Internalization routes influence signaling output WNT3A EGFR LRP6 CTNNB1 PMC9133562__F2 Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials TGFBR2 BMPR2 ACVR2B ACVR2A ALK GRB2 RUNX2 PMC3150418__F9 NFKB signaling participates in both Receptor Activator of NFKB Ligand- (RANKL) and interleukin-4- (IL-4) induced macrophage fusion: Receptor cross-talk leads to alterations in NFKB pathways CD44 DCSTAMP RELA RELB PMC5680911__F7 Simplified graphical scheme representing the effect of Caspase-8 depletion on hepatic apoptosis and steatosis in the pathogenesis of ALD CASP9 TG CASP8 CYP2E1 CASP3 PMC4081080__F3 miR-143/145 modulate signaling through the Ras-MAPK pathway RREB1 EGFR PMC5614474__F2 Multiple and bidirectional connections between actin dynamics and endocytosis HGF TIAM1 ARF6 RAB25 PMC7357716__F3 Metabolic Messengers: Adiponectin MAPK1 INSR COX2 HEL-S-11 SIRT1 PMC5460571__F4 Representation of the molecular interaction pathway analysis of the associated and causal genes linked to aneuploidy DSCAM PMS2 APP MTRR SMC2 PMC11507252__F7 Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review MTOR ATG5 PMC4533766__F7 Expression profile of P ACP2 ACP4 HEL-S-62p C2 HEL-S-5 MGMT PMC7931557__F8 Proposed model of the mechanism underlying the expression and function of LINC00958 in TSCC cell proliferation CCNE1 AGO2 CENPK CCND1 PMC11507252__F6 Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review BAX NRF1 SIRT1 PMC5614474__F3 Transcriptional programs controlling endocytosis and genetic reprogramming by endocytosis DRAM1 EGFR TFEB CHMP4C PMC11507252__F5 Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review NLRP3 TLR4 MYD88 PMC8405670__F4 Comparative analysis of therapeutic effects between medium cut-off and high flux dialyzers using metabolomics and proteomics: exploratory, prospective study in hemodialysis SERPINC1 CLU PROS1 RBP4 HABP2 IGF2 KNG1 PMC3845601__F2 Wnt/Beta-catenin signaling pathway SOST APC LRP5 LRP6 WIF1 CTNNB1 PMC6279509__F9 Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels BMP2 MMP2 MMP9 RUNX2 CTNNB1 PMC9465090__F1 System Xc −/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy SLC3A2 ATF3 IPP LOX SP1 GPX4 EGFR RRM2 SLC7A11 ATF4 LCN2 HEL-S-64p PMC4654121__F6 Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells RHEB TSC2 TSC1 RGS10 MTOR EIF4E PMC10940142__F1 Schematic overview describing the target pathway and overall metabolic strategies for heme production SHD CPD CP PMC11727420__F2 Signaling interactions between the Wnt/Frizzled pathway, MINK1, Prickle1, and their downstream effects on cellular processes CLASP2 PHLDB2 MINK1 PMC5764090__F2 HiJAKing the Epigenome in Leukemia and Lymphoma STAT3 JUN BATF EGR1 SGK1 BCL2A1 NFKB2 SOCS3 IRF4 MYC MYD88 NFKBIA JAK1 NFKBIZ PMC5838326__F4 Changes in the hepatic expression levels of genes for gluconeogenesis pathway following castration of bulls HEL-S-133P HK2 PCCA PCCB LDHB ACSS3 PCK1 GPD1 MCEE PCK2 PDHA1 DLAT GPD2 FBP1 PC DLD PFKL PKLR PMC6316656__F2 Hedgehog pathway activation in cancer SUFU PTCH1 SMO IL6 PMC11727420__F5 MINK1 and Hippo pathway regulation LATS1 LATS2 MINK1 PMC5764090__F1 HiJAKing the Epigenome in Leukemia and Lymphoma STAT3 IL3 LIF EPO TPO PMC11727420__F4 MINK1 and JNK signaling pathway interaction HEL-S-31 MINK1 TNIK PMC11011055__F7 Targeting Siglec–Sialylated MUC1 Immune Axis in Cancer GAL GNE NANS PMC11854358__F8 Analysis of cell cycle pathways and differentially expressed genes because of different levels of PFESA-BP2 exposure CDC2 EGR1 ECT2 SOCS2 CCNA2 MYC MAD2L1 TACC3 PRC1 CDK2 BMF MCM2 TOP2A CDK4 PMC11854358__F7 Proposed effect of low-dose PFESA-BP2 exposure on the hepatic fibrosis signaling pathway in the liver [59] CDC2 BIRC5 IGF1 EGFR CCNA2 MYC PMC8730820__F2 Multiple MuSK signaling pathways and the aging neuromuscular junction MUSK LRP4 SMAD1 CAD DKFZp781O1323 F2 SMAD4 CTNNB1 PMC6115007__F2 Iron in Type 1 Diabetes Etiology: A Systematic Review of New Evidence on a Long-Standing Mystery TF BMP6 HFE PMC5576560__F2 Ten Strategies of Interferon Evasion by Viruses STAT1 STAT2 IFNAR2 IRF9 IFNAR1 RNASEL TYK2 PMC6868788__F8 Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway OTUD7B MMP2 CDK2 MMP9 CCND1 PMC8779696__F1 Host Non-Coding RNA Regulates Influenza A Virus Replication TBK1 ADAR MAVS STAT2 IRF9 PML IRF3 IRF7 JAK1 PMC11292300__F4 The rationale for possible targeted therapies in CMTC STAT3 PORCN APC AXIN1 BRAF PTEN MTOR MYC CCND1 FOS RET PMC11292300__F2 WNT signaling pathway in CMTC APC GSK3B AXIN1 MYC CCND1 CTNNB1 PMC5337177__F2 Mechanisms by which mild mitochondrial uncoupling protects neurons against oxidative stress, excitotoxicity and the accumulation of disease-related self-aggregating proteins such as amyloid Beta-peptide, Tau and Alpha-synuclein TFAM SIRT3 TSC2 MCU ARC MTOR BDNF FOS PMC7933988__F7 Action of mesenchymal stem cells in the vestibular microenvironment STAT3 NMI IL16 MSC MYC TNF PMC7289712__F6 KEGG relationship network diagram IL4 IL6 CCL2 IL1B HEL-S-44 PMC7189706__F5 Hyperglycaemia may influence ten-eleven translocation (TET)-dependent O-GlcNAcylation of the histone methyltransferase SET1/COMPASS complex TET2 OGT TET3 PMC5714221__F9 H1 involvement in the repression of the interferon response STAT1 STAT2 IRF9 IRF1 IRF3 IRF7 JAK1 TYK2 PMC4471797__F1 Wnt/Beta-catenin signaling pathway BCL9 APC GSK3B CCND1 PMC6217807__F6 Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma CDK6 EGFR OLA1 PTEN MDM2 MTOR SHE DAO CDK4 PMC5282855__F1 Biosynthetic pathways of tetrapyrrole compounds COBL CS PMC6217807__F5 Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma BAGE BAD PTEN HIF1A INS PMC7688918__F3 In response to I/R injury, neutrophils migrate from the circulation to the injured heart in response to CXCL and release S100A8/A9 TLR4 CXCL1 S100A8 IL8RB NRF1 PMC8746635__F7 Anti-Inflammatory Activities of the Ethanol Extract of Prasiola japonica, an Edible Freshwater Green Algae, and Its Various Solvent Fractions in LPS-Induced Macrophages and Carrageenan-Induced Paw Edema via the AP-1 Pathway TLR4 MMP2 MMP9 IL1B MYD88 PMC8881374__F2 10 Years of GWAS discovery in endometrial cancer: Aetiology, function and translation RPL8 PARD6A AURKA HEL-S-81p SRP14 GNL2 SLC6A19 MYC CDKN2A WT1 EIF2AK4 CDK6 BMF WNT4 TBX3 LPCAT1 MED17 RPL7A DBH HOXB4 RPL19 RXRA SSPN GPR176 PLCB2 ADAMTS13 BHLHE41 CDC42 RPL35 HEY2 WASL CBX1 TERT RPS16 RPL18A STKLD1 SNX11 OBP2B ADAMTSL2 SLC6A18 SKIDA1 KNSTRN HOXB2 EEFSEC SURF2 CCND1 CACFD1 FAM163B CDK4 ANKRD63 RSL24D1 BAHD1 NKD2 BCL11A HOXB6 MED22 HOXB7 SLC2A6 ABO SH2B3 EP300 RPS12 RAB11FIP4 PMC2877394__F1 ER and SR interactions within mammalian cells STIM1 ULK1 UVRAG BCL2 HP MTOR XBP1 PMC3239234__F3 Various signaling pathways modulated by the primary cilium LRP5 SHH LRP6 SMO CTNNB1 PMC4161976__F7 MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer MDM2 SIRT6 PMC9259972__F2 Long Non-coding RNA HOTAIR in Central Nervous System Disorders: New Insights in Pathogenesis, Diagnosis, and Therapeutic Potential CDK5R1 ATG10 BAX RAB3IP NLRP3 LRRK2 EZH2 BDNF IL1B MYD88 PMC5779720__F2 Distribution of fluxes in the central metabolism predicted by pFBA for the models: iFF708 (green), iMM904 (blue), iTO977 (orange) and Yeast 6 (black) MAL PDC CIT PMC2720726__F1 IFNB activated pathway STAT1 STAT2 IFNAR2 IRF9 IFNAR1 IRF1 TAP1 PMC9376318__F3 CXCL5: A coachman to drive cancer progression CXCR3 STAT3 SOX9 CXCL5 GSK3B IL8RB PMC5779720__F4 Flux distributions simulated with lMOMA for the mevalonate mutant (A) and the acetate mutant (B) using the improved flux distribution as the reference MAL PDC PC SUCO CIT PMC6803553__F3 Signal transduction of GDF11 BAMBI ALK GDF11 TRAF6 PMC6202106__F7 The TGFB/BAMBI pathway BAMBI RORC SMAD2 FOXP3 PMC2238720__F2 Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions RELA RELB IRAK1 TRAF6 IRAK4 MYD88 PMC5190068__F3 KCNN4 and S100A14 act as predictors of recurrence in optimally debulked patients with serous ovarian cancer KLF4 S100A14 KCNN4 PMC7550684__F1 Signaling pathway of Interleukin-17A (IL-17A) ARID5A TRAF5 TRAF6 TRAF2 PMC10178416__F2 Schematic drawing presenting signaling pathways affected by ferulic acid BAX TGFB1 KEAP1 TLR4 SMAD2 SMAD4 PMC9495760__F1 Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? INSR IL6 IRS1 IL1B PMC4331476__F4 Representative illustration of key gene distribution (hsa04720 and LAP_hsa04720s) PPL PMC3232027__F2 Identification and development of mPGES-1 inhibitors: where we are at? COX1 PMC4030640__F2 Molecular and biophysical characterization of the human blood-nerve barrier: Current concepts GDNF RET CTNNB1 PMC3994981__F2 PI3K and Cancer: Lessons, Challenges and Opportunities RHEB RICTOR GRB10 ULK1 PTEN MTOR MYC EIF4E PMC3994981__F1 PI3K and Cancer: Lessons, Challenges and Opportunities PIK3CA PTEN MTOR PMC6101676__F1 Mevalonate-isoprenoid-cholesterol pathway and pharmacological agents that inhibit the synthesis of key intermediates IPP HMGCR RHO PMC10272955__F8 Graphical summary of the signaling pathway that mediates fenofibrate (FF)-induced cytoprotection against cisplatin toxicity KEAP1 AHR PMC4839493__F1 The metabolic pathway for vitamin D CYP2R1 CYP27B1 CYP24A1 PTH FGF23 PMC4839493__F7 1,25(OH)2D3-induced signaling pathways involved in the regulation of cell proliferation, apoptosis, and inflammation in cancer NR1i1 BAX EGFR APC CDK2 HEL-S-11 IL6 CCND1 PMC8106830__F1 Cascade of innate immune response against intestinal fungi SYK CXCR1 CARD9 PMC2653622__F2 PRIMARY CILIUM: AT THE CROSSROADS OF MAMMALIAN HEDGEHOG SIGNALING SUFU SHH SMO GLI3 PMC8146326__F8 Extracellular Vesicle Release Promotes Viral Replication during Persistent HCV Infection ROCK2 ROCK1 ARF6 ARHA PMC4452063__F2 The Wnt/Beta-catenin signaling pathway and the regeneration therapy drug candidates discussed in the paper BCL9 SOST APC LRP5 LRP6 CTNNB1 PMC4452063__F1 The Wnt/Beta-catenin signaling pathway and the oncology-indication drug candidates discussed in the paper BCL9 APC LRP5 LRP6 CTNNB1 PMC7645992__F10 Prosed schematic proposed mechanism underlying the impact of DDP4 inhibition on protecting the cell from apoptosis and oxidative stress through regulating the PI3K/AKT/m-TOR signaling pathway IL6 MTOR IL1B PMC4434706__F1 Two S-phase checkpoint responses in S MRC1 DNA2 RAD17 PMC7550684__F3 Relationship between IL-17A and astrocytes STAT3 SOCS3 IL1B PMC11993841__F6 Influence of porous metal materials on osteogenesis RUNX2 CTNNB1 PMC11899827__F1 IL-17 signaling pathway in the pathophysiology of spondyloarthritis IL17RC ERAP1 TNF IL23R PMC9187083__F9 Understanding pathogen–host interplay by expression profiles of lncRNA and mRNA in the liver of Echinococcus multilocularis-infected mice STAT3 STAT1 TIRAP IL13 SMAD2 FOXP3 CXCL10 EGR2 MYD88 PMC2692823__F2 Hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem KY STIM1 TRPC6 PMC9585190__F7 Metformin on Sonic hedgehog subgroup medulloblastoma progression: In vitro and in vivo studies SUFU SHH SMO PMC8062309__F2 T helper cell changes locally and peripherally in healthy pregnancy and preeclampsia IFNG CD80 PMC8062309__F1 Local and systemic complement activation in preeclampsia and healthy pregnancy and complement-modulating medications CD59 HEL-S-62p CFI C2 C1S CFHR1 C1R CFH CD46 CD55 PMC4487780__F1 NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus NAPRT HEL-S-90n NMNAT1 NAMPT NMNAT2 NMNAT3 PMC3316974__F1 AKT-mTOR signaling pathway showing rapamycin inhibition sites in astrocytomas TSC2 TSC1 PTEN MTOR PMC3159974__F4 Predicted synthetic lethal gene pairs in TCA cycle (A), phosphatidylserine biosynthesis (B) and pentose-phosphate pathway (C) PTDSS2 RPE HEL-S-304 RPIA CHPT1 PTDSS1 PC CEPT1 PCYT2 PMC209477__F2 gp130 cytokine family pathways on anterior pituitary cells CNTF OSM LIF CD14 LBP PMC8328385__F1 Alopecia Areata: An Autoimmune Disease of Multiple Players CXCL9 CXCL11 CXCR3 PDC ELL CXCL10 PMC5592089__F1 PI3K/AKT/mTOR pathway and interaction with PTEN and TSC1/TSC2 RHEB BAD TSC1 EGFR PTEN GRB2 MTOR TTF1 IRS1 PMC5520933__F1 The lithium targeted cellular and molecular mechanism by activating several neurotrophic and associated signaling in Alzheimer’s disease REST GSK3A APP BDNF PMC6513185__F4 Effects of flavonoids on signaling pathway of NLRP3 inflammasome activation SYK NLRP3 TXNIP TLR4 IL1B PMC6412533__F10 Gemcitabine pathway extracted from PharmGkb database CDA RRM1 RRM2 SLC29A1 SLC28A3 CMPK1 DCTD PMC4468843__F1 NFKB pathway COX2 IL1B MYD88 PMC7235190__F5 Regulatory mechanism of HDAC2/3 on LPL expression in SH-SY5Y cells HDAC3 LPL HDAC2 PMC4061164__F1 Cisplatin-induced inflammation is mediated through multiple effectors including activation of NFkB, TNFA, and PARP STAT3 HGF VCAM1 PMC6513185__F2 Flavonoids on the expression of MMP and ADAMTS in osteoarthritis STAT1 STAT2 PMC6099536__F1 IL-33 signaling pathway IL33 SIGIRR IRAK1 IRAK4 UNK MYD88 PMC3094853__F1 CHS-catalyzed synthesis of unnatural polyphenols from cinnamoyl-SNAc starter substrates with a) malonyl-CoA and b) methylmalonyl-CoA as extender units CSA2 RRH PMC9253771__F3 Combinatorial CRISPR Interference Library for Enhancing 2,3-BDO Production and Elucidating Key Genes in Cyanobacteria TRO C2 PMC3780472__F2 Biochemical changes during EMT in fibrosis CDH2 ZEB2 PMC5929146__F1 Metabolomics Applied to Islet Nutrient Sensing Mechanisms CIC PC HEL-S-26 PMC3270883__F1 Exiting from uncharted territory: hepatitis C virus assembles in mouse cell lines CD81 SCARB1 APOE LDLR CLDN1 PMC6539061__F2 Polycystin-associated pathogenic mechanisms in human diseases STAT3 STAT1 RUNX2 PMC7177523__F2 Schematic figures showing various signaling molecules influenced by the CO-HO-1 pathway RHEB TSC2 TSC1 AMIGO2 GSK3B TBC1D7 PTEN MTOR SIRT1 PMC7345337__F5 Gene–gene interaction network analysis SGK1 PIK3R3 USP11 BRAF MAPK9 HRAS TSC2 GRB10 IGF1 ATG12 INSR MOS CREBBP NRAS MDM2 PMC6406504__F2 Differentiated insulin-producing cells (IPCs) for transplantation TF HGF PDX1 PAX4 MAFA SHH HP PMC11534612__F1 Pathophysiologic roles of IL-17 signaling in cardiac fibrosis IL17RC CDX2 CXCL5 CXCL1 IL17RB TRAF5 IL6 CXCL10 TRAF6 CXCL8 TRAF2 PMC7957753__F9 Signal transduction and regulation of secondary metabolism in response to salt stress in S TF MYB MYC PMC4032892__F1 Schema of PI3K/mTOR and other oncogenic signaling pathways in hematologic malignancies PTEN MTOR EIF4E PMC4516161__F4 CIB1 regulation of TNBC cell survival and potential role of CIB1 in non-oncogene addiction PAK1 PTEN PMC4316650__F3 Pathways and networks associated with proteins with differential abundance according to IPA CRP TF HSPG2 MASP2 LMAN2 AMBP HEL111 APC SERPINA1 CS KLK8 APOH F2 FGA HP TYMP LBP CP PMC4956769__F4 Features of an altered AMPK metabolic pathway in Gilbert’s Syndrome, and its role in metabolic health UGT1A1 PGC SIRT1 PMC4283800__F1 Hypoxia and the extracellular matrix: drivers of tumour metastasis PLOD1 LOXL2 LOX LOXL3 LOXL4 P4HA3 P4HA2 LOXL1 PLOD3 PLOD2 P4HA1 PMC4766460__F2 Plasticity of gene‐regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators CTNNB1 RSPO1 DMRT1 PTGDR SF1 SOX9 SRY DKK1 NR3A2 FGF9 SOX3 AMHR2 SOX8 PMC6554024__F5 Decoding type I and III interferon signalling during viral infection STAT1 STAT2 IRF9 JAK1 TYK2 PMC6554024__F4 Decoding type I and III interferon signalling during viral infection TBK1 CGAS RIGI MAVS TLR3 IRF3 IRF7 TLR7 MYD88 PMC5417569__F6 Transcriptome analysis of muskrat scented glands degeneration mechanism LTBP1 SMAD1 SP1 SMAD2 SMAD6 SMAD4 NODAL ARHA TNF PITX2 IFNG RBX1 FST SKP1 PMC4404594__F1 Model of CIP2A involvement in the EGFR-RAS signaling pathways CIP2A EGFR KRAS PMC5417569__F5 Transcriptome analysis of muskrat scented glands degeneration mechanism PLN CAV3 CAV2 TNC BCR MCU PMC10539698__F3 Emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages STAT3 COX2 CCR5 CCR2 MTOR PMC5938036__F2 The metabolites generated from alternative vitamin D metabolic pathway NR1i1 CYP27B1 CYP24A1 CYP11A1 CYP27A1 RORA PMC5287080__F3 Transforming growth factor B (TGFB)-induced activation of the PI3K-Akt pathway SMAD4 TWIST1 PMC5287080__F2 Transforming growth factor B (TGFB)-induced activation of c-Jun amino terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) signaling, and the IKB kinase (IKK) pathway SMAD2 SMAD6 SMAD4 SMURF2 TRAF6 PMC5287080__F1 Transforming growth factor B (TGFB)-induced activation of the extracellular signal-regulated kinase (Erk) mitogen-activated protein kinase (MAPK) pathway SMAD2 SMAD4 GRB2 PMC3397508__F1 Possible molecular mechanisms of Ngb neuroprotection by modulating cell death/survival signaling pathways HEL-S-62p C2 NGB CYC1 PMC4306509__F6 Human disease mutations in short linear motifs NKX3-1 BAD CDK2 BCL2 PTEN MDM2 MTOR PMC7809767__F3 AURKA interactome and related signaling pathways AURKA KCTD2 LIMK2 GSK3B SMAD4 CPAP GABPB1 BCL2L11 CTNNB1 TACC3 LATS2 RALA IKBKB PRKCA NFKBIA ZNF207 CENPA AJUBA MDM2 NF2 GABPA PMC8905338__F5 Personalized Management of Pheochromocytoma and Paraganglioma MAX HDAC1 TMEM127 NF1 SSTR2 EGFR FGFR1 RET MERTK PMC2907875__F8 Estrogen and Xenoestrogens in Breast Cancer BMP6 NRG1 STXBP6 RARB SPRY1 PMC5742588__F3 The folate cycle is fueled by the serine synthesis pathway (SSP) and extracellular serine MTHFD1 SHMT1 PSAT1 HEL-S-51e PSPH PMC3387977__F3 Targets for inhibition within the EGFR signaling pathway EGF TGFA EGFR MTOR PMC8669111__AF1 Glutathione synthesis primes monocytes metabolic and epigenetic pathway for Beta-glucan-trained immunity GLS HK2 GCLC EZH2 MTOR CIT PMC3804751__F7 Model showing the cRAF-dependent modulation of DC responses by TcES IL10 TLR4 MYD88 PMC6933576__F11 Apoptotic pathway and targets for complexes 1, 2, 3, and 4 CASP9 CASP8 CASP3 PMC4401614__F1 Cbl pathways CBL APC PMC4046670__F6 Prioritized genes in apoptosis and TNFR2 signaling pathways BAD FAS PMC4086377__F1 TGFB Signaling in Wound Epithelialization TGFB1 SMAD2 SMAD6 SMAD4 TGFBR1 PMC9162042__F3 Multifaceted regulation and functions of 53BP1 in NHEJ-mediated DSB repair (Review) USP14 ATR CUL4A SP1 BRCA1 H2AX FOXK1 DTL ATM RIF1 MDC1 PMC6171999__F1 Targeting B-cell receptor signaling in leukemia and lymphoma: how and why? BTK BCR BLNK LYN GRB2 RAC1 PMC5356579__F2 Somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy ARID1A DKK4 FZD10 SMAD2 BRAF SMAD4 PTEN IGF1R MYC TGFBR1 CTNNB1 TGFBR2 FBXW7 SOX9 DKK1 ATM DKK2 ACVR2A APC LRP5 KRAS IGF2 AXIN2 ERBB3 DKK3 TCF7L2 ERBB2 PMC5122439__F2 RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action ARAF HRAS SPRED1 SOS1 EGFR BRAF IGF1R GRB2 KRAS PMC3693464__F1 Transcriptional Control of Cellular Metabolism by mTOR Signaling RHEB TSC2 TSC1 NF1 EGFR ATM PTEN PMC3806867__F5 High-Throughput 3D Screening Reveals Differences in Drug Sensitivities between Culture Models of JIMT1 Breast Cancer Cells HEL113 TIMP3 SLPI RAB31 SPARC KLK3 PTEN ID1 S100P CD47 pp6425 WNT5B EMP1 PCK2 LAMP2 PLAT ITGB1 TMEPAI IGFBP5 ETV4 DKFZp686P11128 NOTCH1 PMC8818677__F9 Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial-to-Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing IKBA ULK1 MTOR SKP2 PMC9708732__F3 Microglia autophagy in ischemic stroke: A double-edged sword NLRP3 ATG12 ULK1 TLR4 BNIP3 ATG5 TRAF2 PMC12078810__F7 ART inhibits hepatocellular carcinoma cells TLR4 TRAF6 MYD88 PMC5954603__F1 Involvement of exosomes in peritoneal dissemination CD44 EGFR LAMC1 PMC3061884__F9 100 frequent associations obtained after p value cut off in MCL with CDCOCA TRAF4 SMARCE1 CARD11 NSMAF RPL30 YWHAZ PMC8977221__F1 Systemic Therapy for Hepatocellular Carcinoma: Current Updates and Outlook HEL-S-92n CD80 PMC9484955__F6 Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy FIS1 OPA1 MEN1 BNIP3 FUNDC1 PMC7247011__F5 Fe deficiency responses in photosynthetic organisms FER C2 PC FES PMC8745381__F3 Melatonin in Obesity: A Review STAT3 ANGPTL4 NLRP3 TLR4 EPO NFIL3 SIRT1 MPO PMC7247011__F3 Fe-responsive proteins with relevance for photosynthesis in Cyanobacteria, Chlamydomonas, and land plants FUT8 FER PC FES NACA PMC9484955__F1 Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy RYR2 BAX NLRP3 IL18 PMC8955027__F2 Glucose Metabolism and Aging of Hematopoietic Stem and Progenitor Cells ACLY HEL60 ENO2 SLC25A20 CS ACADM PYGL HADHB SUCLG1 SUCLA2 MSC SLC25A1 ACADVL AGL MDH2 HEL-S-26 PFKM PKLR ECHS1 AGPS GOT2 CRAT FH ACO2 PYGB ACADS HEL-S-30 PDHX EN2 PGAM1 SDHB DLAT PDHA1 GPD2 PHGDH HEL-S-68p OGDH PFKP HEL-S-162eP HEL-S-49 SUCLG2 DLD ENO1 ACADL CPT1A PMC7910587__F6 Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry CDC42 VAV2 EGFR IQGAP1 SRC RAC1 PMC3061884__F7 100 frequent associations obtained after p value cut off in BLCA with CDCOCA PPP3CC PSMD2 FNTA PMC6005571__F10 Neurogenesis and mediators of neuroendocrine stress responses EGR1 SH3GLB1 NEUROD1 VSTM2A GABRB2 PENK CDK5R2 TRPV1 NAMPT CCNI EDIL3 CTCF DAB1 RAD21 CDK5 SERPINE2 PAWR NTRK1 CARTPT CAMK4 PMC5979342__F5 miR-302s target genes are involved in the loss of epithelial phenotype BARX2 ITGB4 PCDH7 APC TNS1 PRRX1 TGFBR2 CD44 INHBB PKD1 DCX DRD1 BTG1 FZD3 ADAM9 GDF11 ZBTB33 LMX1A CDH6 FGF9 RNF6 LAMA3 LEF1 KAT2B PMC6072839__F2 Molecular signalling of TRAIL RIPK1 TRAF2 FADD PMC5396384__F3 Inositol polyphosphates synthetic pathway ITPK1 ITPKA IPMK ITPKC PPIP5K1 IP6K1 PMC8410881__F1 Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression INSR PFKP HK2 RS1 HEL-S-87p HEL-S-30 PFKM PMC8121456__F2 CGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease TBK1 STAT1 CGAS STAT2 IRF9 IRF3 PMC8121456__F1 CGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease TBK1 CGAS TLR9 AIM2 IRF3 IRF7 IL1B MYD88 PMC11956211__F6 Apoptosis signaling pathway in KEGG TF CAD CASP2 OSM H2AX MLKL IL33 TNF PYGL LOX PIG59 NLRP3 ATM HEL-S-11 USP21 CYLD FADD ADA PMC8745310__F1 Ubiquitin Signaling in Innate Immune Response by Herpesviruses TRIM31 TBK1 RNF122 MAVS ITCH IRF3 OTUD1 TRIM21 RNF125 USP15 TRIM25 TRIM29 TRIM65 PMC8131930__F3 Aspergillus fumigatus and aspergillosis: From basics to clinics C2 F2 PMC8660704__F7 DCZ0014, a novel compound in the therapy of diffuse large B-cell lymphoma via the B cell receptor signaling pathway STAT3 SYK CDK6 BCR CD19 LYN MTOR CCND1 CDK4 PMC10925712__F1 Schematic biosynthetic pathways of tocopherol and tocotrienol synthesis IPP PMC8745310__F3 Ubiquitin Signaling in Innate Immune Response by Herpesviruses TRIM31 NLRP1 ARIH2 AIM2 IFI16 USP47 BRCC3 PMC8745310__F2 Ubiquitin Signaling in Innate Immune Response by Herpesviruses USP44 RNF185 TBK1 CGAS TRIM32 TRIM56 RNF5 TRIM41 IRF3 USP29 MUL1 USP20 TRIM29 CYLD PMC11674646__F1 Interactions and connections between the gut microbiota, metabolites, and cellular components with IBS COX2 BMP2 AHR PMC8787237__F3 STING1 in sepsis: Mechanisms, functions, and implications CASP3 IRF3 MITA PMC11795048__F1 Design and application of A@HAP NPs in cancer therapy STAT3 HMGB1 NPS PMC2376838__F8 LRG-Accelerated Differentiation Defines Unique G-CSFR Signaling Pathways Downstream of PU.1 and C/EBPE That Modulate Neutrophil Activation TF STAT3 EPO PMC7181720__F1 Proteomic analysis of the OTULIN protein complex PUM1 TSC2 TRIM32 ATP2C1 HK2 OTULIN OSBPL8 GNL3L PMC5045091__F2 Modification of the HIF-mediated switch to anaerobic respiration in osteoclasts.Notes: Osteoclasts specifically increase flux through both the glycolytic pathway and mitochondrial ETC to provide ATP and ROS necessary for bone resorption PFKFB4 NFATC1 PMC8955970__F1 Endometrial Cancer Stem Cells: Where Do We Stand and Where Should We Go? EGF SOX2 MTOR CTNNB1 PMC3546980__F7 Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo TIMP1 KIF7 SUFU SHH SMO MTOR MYC PMC10559930__F1 Mechanism involved in ZNF703 including the signaling pathway, upstream regulation network and downstream targets RB1 NCOR2 DCAF7 ZNF703 MTOR PMC10897204__F6 Newly identified APA-linked cancer susceptibility genes are enriched in metabolic reprogramming and apoptosis-related pathways CMC2 STXBP4 PIK3CA MAU2 RAF1 SRP14 GGCX PIK3R1 MXRA7 SPG7 HEL-S-20 ZNF346 ZNF276 SRC FBLN2 NOTCH1 BBS2 SMG9 FGF10 POLR2J PREX1 VPS35 RUTBC3 BRCA1 PLEKHO1 RNF181 BAK1 CASP10 HEL107 SLC25A37 FAS UTP4 BRCA2 PTEN TERT CBX8 NCF1 STRADA TLK1 ARMC10 CHEK2 DMXL2 RASA4 CYBC1 HMGN3 STRADB NBPF19 BPTF KRAS TMEM138 CHMP4A SUPT4H1 ATG10 SLC17A9 FAM177A1 KANSL1L ARL14EP YIPF4 CALHM6 POLR3C SPATA33 PHF5A RUNDC1 MAP2K1 PMC8656491__F1 Impact of DNA Damage Response—Targeted Therapies on the Immune Response to Tumours WEE1 ATM PARP2 SSB PARP1 PMC5803917__F4 AP1 and CEBP mediated skin barrier impairment by BM TF CASR CD44 PIK3CA JUN PLCG1 FYN SP1 PKN2 CEBPB PMC5803917__F3 TNF mediated anti-inflammatory effect of BM SELE GC CCL2 PMC5803917__F6 Factors implicated in manifestation of disease during drug treatment RB1 CRK PXN PC SOCS3 PRKCB PMC7882032__F4 Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity TSC2 ATR TSC1 ATM SESN1 MDM2 SESN2 PMC8626541__F1 FA-BRCA Pathway FANCD2 REV1 RAD51 BRCA2 FANCM FAAP24 PALB2 SLX4 UBE2T PMC6493882__F2 Two potential grounds for attenuation of IFN‐B bioactivity by statins IFNG STAT1 IL10 IL4 TNF PMC7498011__F5 Rps27a might act as a controller of microglia activation in triggering neurodegenerative diseases IFNA13 PDCD1 LTBR FCER2 PLSCR1 PIK3CD IL27 IKBKE KLRF1 C1QBP TRAF3 TRIM21 TREM2 DRD2 HLA-E PRKCE HLA-F IL18 ITK CYBA SRC IL31 UBB TNFRSF4 TNFRSF9 RPS27A HEL-S-78p CAPZA1 PRG2 ITGB1 IL24 DEFB123 SRMS IL6ST POLR3K CORO1A JAK1 IL10RB PMC5206550__F1 Hypothetical representation of the link between the Hog1 MAPK and the lipid metabolic pathways activated in R CDS1 PSD2 PMC2808241__F7 Genomic Profiling of Messenger RNAs and MicroRNAs Reveals Potential Mechanisms of TWEAK-Induced Skeletal Muscle Wasting in Mice TCAP NRAP MYC ANKRD2 TEAD4 PSMD3 FBXW7 NID2 TTN MARCKSL1 PRELP LMO1 NOTCH3 DNER NOTCH1 GAA JUN MYH4 FLG IVL FOS PGAM2 SFRP4 MFAP2 ENO1 BIRC2 PMC12133740__F1 Integrated schematic of glycolysis, mitochondrial metabolism, and lipid pathways in NSCLC cells HEL-S-133P HK2 FASN MPC1 CPT1A PMC3703418__F2 Cellular mechanisms of BBR in reverting dysfunction in NAFLD NR1C1 INSR IL6 PMC12133740__F3 Targetable metabolic pathways and inhibitors in NSCLC ACLY SLC3A2 ASS1 FAS ASL HEL-S-133P EGFR SCD FASN OTC ARG1 MTOR SLC7A5 MYC ALK HEL-S-68p PHGDH PSAT1 SLC5A6 PSPH PMC4935775__F1 Na+-Cl− cotransporter (NCC) regulation by the cullin-3 (CUL3)/kelch-like 3 (KLHL3)-with no lysine (WNK)-STE20/SPS-1-related proline/alanine-rich kinase (SPAK)/oxidative stress response kinase (OSR1) pathway KLHL3 OSR1 PMC10498649__F2 Lipid metabolic alterations induced by oncogenic events and TME cues ACLY GLUD1 ACSS2 CD36 FASN PTEN MYC PMC3671288__F2 Inhibitory pathway of PGE2 in effector T cells CSK FOXP3 LCK PMC3671288__F1 General overview of synthesis pathways for eicosanoids COX1 COX2 PC PMC8703113__F3 Caveolin-1 Regulates Cellular Metabolism: A Potential Therapeutic Target in Kidney Disease MTOR PMC9017014__F1 Dysregulation of Wnt signaling in bone of type 2 diabetes mellitus and diabetic Charcot arthropathy TCF7L2 WNT3A LRP5 RUNX2 PMC3871639__F5 Inflammation Regulates TMPRSS6 Expression via STAT5 STAT3 BMP6 SMAD1 DKFZp781O1323 TMPRSS6 HFE2 PMC9266358__F8 Transcriptomic and Metabolomic Analysis of Quality Changes during Sweet Cherry Fruit Development and Mining of Related Genes ACLY MAX KHK CAD APOH SORD PDC PMC3188880__F2 Stat3 interactions in glioma biology IFNG STAT3 OSM EBP BMP4 LIF PMC6257835__F7 Involvement of circRNAs in the Hippo signaling pathway WNT16 BMPR1A SMAD2 GSK3B SMAD4 BBC3 FRMD6 CTNNA3 BIRC5 WWTR1 FZD3 PPP2R2B HEL-S-1 BMPR2 PPP2R2C SNAI2 ID2 DLG4 AREG YAP1 PRKCI TCF7L2 FZD4 PARD3 BMP5 CTNNA1 WNT10B DLG2 TP73 RASSF6 FZD5 TGFB1 BMP8B TP53BP2 PPP1CC FBXW11 PPP2CA FRMD1 TGFBR1 CTNNB1 TGFBR2 LATS1 CTNNA2 MOB1A MOBKL1A LATS2 BTRC CCND2 YWHAQ HEL-S-80p TEAD3 BMP4 FZD1 NF2 HEL2 YWHAG CRB1 SOX2 FZD7 BMP7 PPP2R1A AXIN2 ID1 GDF6 PARD6G WWC1 PPP2R2A PPP2R1B PARD6B BMP2 DVL3 SCRIB LEF1 PS1TP5BP1 YWHAZ PMC6257835__F6 Involvement of circRNAs in the ErbB signaling pathway PIK3CA RAF1 SOS1 SHC1 PIK3R2 GSK3B PIK3R1 MAPK8 NRG4 EREG CAMK2A PLCG2 STAT5B PRKCA BTC SRC MAPK1 NCK1 CRKL AREG ERBB3 NRG2 CRK HBEGF CDKN1A SOS2 PAK1 CDKN1B MAPK10 GRB2 EGF TGFA PIK3R5 ABL2 PIK3R3 EGFR AKT3 RPS6KB2 PAK4 BRAF NRG3 MTOR NCK2 PRKCB SHC4 MAP2K4 PAK6 SHC3 JUN ERBB4 KRAS NRG1 CBL CAMK2D RPS6KB1 ERBB2 MAP2K1 CAMK2G PMC8438979__F4 UHPLC-MS-MS analysis of oxylipins metabolomics components of follicular fluid in infertile individuals with diminished ovarian reserve LTB DIO1 LTA PMC5737940__F2 Cellular signaling pathways through which NELL-1 works NELL1 APC GSK3B LRP5 LRP6 SMO RUNX2 CTNNB1 GLI3 PMC10887358__F2 Signaling pathways of B cell receptor (BCR) CD79B SYK CD79A FYN BCR PLCG2 CD22 BLNK LYN PMC12154347__F7 Dihydrocapsaicin Enhances Tumor Necrosis Factor-Alpha-Induced Apoptosis and G1 Cell Cycle Arrest in Human Cervical Cancer Cells Through TAK1-Mediated NFKB and EGFR Pathways EGFR TNF CCND1 PMC8610843__F3 Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications CXCL12 HMGB1 NLRP3 TLR4 VEGFA SRC TNF ACE2 CTNNB1 PMC7320752__F6 Protein interaction pathway analysis in metastasis POC5 DVL1 WDR51B PIK3CA WDR45B WNT8A RAF1 SOS1 WNT3A PIK3R2 FGF7B PIK3R1 GSK3B DCTD MYC RB1 FRAT1 CDK6 FLT4 E2F3 FGFR1 RTN1 CSNK1A1 POLE AHCYL1 RPGRIP1L NOTCH1 POLE2 SP1 TFDP1 PKIG APC AGTR1 KSR1 LRP5 LRP6 DVL2 DUT DDB2 TCF7L2 IGF1 DTYMK UBE2B CDKN1A SOS2 AXIN1 TNFSF11 WNT3 UBE2A VCAM1 BAK1 WNT8B ZFYVE21 WNT10B FZD5 PGR ORC6 FGF21 NFKB2 INSL4 AKT3 RPS6KB2 SHC2 SUMO1 FGF7A SUMO3 SUMO2 FGF9 JAG2 VPS4B NOTCH3 DLL3 FGF16 DBF4 UBE2M KIT TCF7L1 ORC3 HEL-S-70p KRAS ORC2 ARAF FGF7 CCNE2 PHGDH FGF20 ERBB2 FGF18 LEF1 UPF2 WNT16 SHC1 UBE2C PIK3CD WNT9B WNT10A FGF8 WNT5B FGF8A SBDS ATP6V1C1 FZD8 WNT1 WNT4 HES1 HES5 REXO2 LIMS1 FGF22 IGBP1 ILF3 PRIM2 FGF5C FGF10 NOTCH2 PRIM1 WNT7B FOS ADSL HRAS PGAM1 MCM7 POLA2 MCM10 BRCA1 ATP6V1E1 MCM3 CDK2 MCM5 MCM6 GRB2 MCM2 TNIK EGF UFC1 HEY2 FZD10 EGFR BRCA2 BRAF IGF1R PTEN MTOR APC2 CTNNB1 SHC4 NR3A2 WNT7A WNT9A HEL-S-52 CCND1 SHC3 FGF23 CDK4 UNK BAX JUN ITGA4 E2F2 DLL4 FZD7 EIF5A FGF6B SAE1 NCOA1 FGF2 FZR1 ZRANB2 FRAT2 RPS6KB1 DVL3 SH3GL2 MAP2K1 ZFYVE19 UBXN7 ARHGEF35 PROSER2 PMC5518631__F1 Agrin signaling and YAP in neuromuscular junction formation (NMJ) and liver cancer development MUSK LRP4 PMC7191280__F1 SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications TMPRSS2 IFNG ATR ADAM17 ACE2 PMC7086350__F1 DDR core gene amplification across pan-cancer ALKBH2 SLX1B PMS2 FANCM FANCL FANCA FANCC FANCB FANCD2 REV1 UNG POLE PALB2 TDG MGMT TDP1 POLL MSH6 RAD52 ATRIP POLM RAD50 MSH2 RAD51 MSH3 NHEJ1 NBN MDC1 RBBP8 UBE2T XPC TP53BP1 PMS1 BARD1 XRCC5 MLH3 BRCA1 APEX1 POLE3 ERCC5 REV3L ERCC1 BRIP1 ATR ERCC2 ALKBH3 BRCA2 BLM CHEK2 ATM FEN1 RNMT PARP1 XRCC3 PRKDC CHEK1 GEN1 TREX1 POLN APEX2 EME1 PMC8130467__F5 Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis TMPRSS2 VWF ACE2 MYD88 PMC3594545__F2 Regulation of NFKB by Ubiquitination TBK1 MAVS TRIM25 TANK IRF3 PMC3594545__F1 Regulation of NFKB by Ubiquitination SHARPIN TAB3 TRAF6 IL1B PMC6779827__F2 Innate immune pathways inhibition by calicivirus infection IRF3 F9 EIF4E PMC8105803__F7 Map of p53 signaling pathway regulated by LEP gene drawn through the KEGG database SYK TSC2 BAD BCR TLR4 PTEN PMC8105803__F6 Map of PI3K/AKT/mTOR signaling pathway regulated by the LEP gene drawn through the KEGG database CASP9 TSC2 ATR AIFM2 PERP ATM PTEN HEL-S-11 MDM2 MYC PMC6311566__F1 Overview of metabolic pathways implicated in epigenetic modifications in NSC TET2 SIRT1 PMC8902310__F3 Type I Interferon Responses to Influence Tumor-Immune Cross Talk in PDAC STAU1 TBK1 CGAS MAVS TLR3 IRF3 TRAF3 ENPP1 PMC4914279__F8 Epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells CDC42 ROCK2 EGFR ROCK1 ARHA RAC1 PMC3361682__F2 UCB interaction with neural plasma membrane (A) and pathways by which UCB may affect neuronal function (B) BAX C9 TRAF2 PMC4935960__F6 Independent Tumor Origin in Two Cases of Synchronous Bilateral Clear Cell Renal Cell Carcinoma WWP1 SMAD1 UBE2Q2 SUFU EGFR PTCH1 KDM5C SMO PTEN MTOR FGF10 VHL PMC6678135__F7 Compounds that inhibit and activate autophagy ATG10 ATG3 ATG12 ULK1 UVRAG ATG14 MTOR ATG5 ULK2 PMC8446193__F2 Murine Models Provide New Insights Into Pathogenesis of Chronic Graft-Versus-Host Disease in Humans TEC TH STAT3 CD69 APC PDC PMC6538418__F1 Key players in autophagosome formation ATG3 ATG12 ULK1 ATG14 BCL2 MTOR ATG5 ULK2 PMC11356322__F3 Metabolic pathway interaction network of Cluster-0 metabolite (4-hydroxybenzoic acid) PDSS1 SULT1A1 SQLE KMO COQ2 COQ9 COQ6 COQ5 PMC7002700__F5 Schematic showing the signaling pathway of miR-125a-3p- Fyn–NRP1 interaction by TNFA in DPSCs DSPP FYN NRP1 CTNNB1 PMC5642637__F2 miR-708-5p: a microRNA with emerging roles in cancer CD44 NNAT KPNA4 PMC6788064__F2 Signaling pathways participating in the function of cadherins in cancer CDH2 APC PTEN PMC8610843__F1 Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications TMPRSS2 NRP1 ACE2 PMC9652569__F5 Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking RAF1 CCNA2 MYC MAPK8 CCL2 CXCL8 MAPK14 RB1 IFNG HMOX1 BCL2L1 PRKCA MMP2 MMP3 KDR HEL-S-44 MAPK1 CASP9 NOS2 SLPI IL1A VEGFA CXCL10 FOS GSTM1 CDKN1A RXRA BCL2 EGF EGFR LYZ NR1C2 RUNX2 MPO PRKCB NR3A2 CHEK2 AHR CHUK IL2 CCND1 RXRB TOP2A IL1B CRP CYP1A2 BAX IL10 JUN SELE IL4 CXCL2 CD40LG OPRM1 MMP9 IL6 CYP1A1 IGF2 SPP1 NR1C1 HEL-S-130P IKBKB RELA CASP3 CHEK1 HEL-S-102 NFKBIA MGAM CYP3A4 PMC6197473__F2 Snapshot of protein-protein interactions involving p85A (the “p85A network”).The binding to PTEN and to BRD7-XBP1 has a negative effect on PI3K activity (red color), the first by stabilizing PTEN, the second via p85A depletion (, , –) CDC42 BRD7 PTEN XBP1 PMC6179164__F6 Mechanisms by which IFNA disrupts thyrocytes to trigger AITDs TG CXCL10 TRIM21 PMC9652569__F1 Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking JUN MAK RELA NFKBIA TNF FOS PMC9639746__F1 Cancer immunotherapy strategies that target the cGAS-STING pathway CGAS APC COIL PMC9652569__F7 Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking JUN RELA TNF PMC12141126__F2 Systemic lupus erythematosus-induced endothelial dysfunction and atherosclerosis CRP VWF VCAM1 PMC3946543__F4 A Lipidomic Perspective on Inflammatory Macrophage Eicosanoid Signaling COX2 C2 PMC7327152__F1 Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis CD36 CCR5 CCR2 CCL2 ABCA1 MYD88 IFNG STAT1 ABCG1 NLRP3 CCL21 VCAM1 IL1B PMC8070608__F2 Plasmin and Plasminogen System in the Tumor Microenvironment: Implications for Cancer Diagnosis, Prognosis, and Therapy RARA TGFB1 FOXC2 SMAD2 PLG PML SMAD4 MTOR TGFBR1 PMC8563889__F1 Ferroptosis, radiotherapy, and combination therapeutic strategies POR IPP NR1C1 SCD DHFR LPCAT3 ATM SLC7A11 ATF4 MDM2 PMC7829660__F3 Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action TIRAP TLR4 CD14 LBP MYD88 PMC9630482__F2 Extracellular vesicles as advanced therapeutics for the resolution of organ fibrosis: Current progress and future perspectives SMAD1 DKFZp781O1323 SMAD2 GSK3B SMAD4 BMP7 CTNNB1 PMC10816780__F15 Transgenerational Transmission of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Effects in Human Granulosa Cells: The Role of MicroRNAs STAT3 VEGFB VEGFC FAS BCL2 MYC PMC5545727__F3 List of 24 CMMDh genes (left), genes enriched to the top canonical signaling pathways (middle) and the network of these genes with mood disorders and the CMD-Rs (right) NCAN SLC18A1 REST LEP APOE GSK3B MTNR1B GNAS TCF7L2 IGF1 ADRA2A TLR4 CRY2 5HT1A POMC ADRB1 BDNF CREB1 ITIH4 PMC7804279__F2 The Hippo pathway in the pathogenesis of inflammatory bowel disease LATS1 TF LATS2 PMC7804279__F1 The Hippo pathway in the pathogenesis of inflammatory bowel disease LATS1 LATS2 NF2 VGLL4 PMC7804279__F4 The Hippo pathway in the pathogenesis of inflammatory bowel disease LATS1 LATS2 VEGFA PMC7804279__F3 The Hippo pathway in the pathogenesis of inflammatory bowel disease STAT3 SMAD2 FOXP3 PMC8803653__F2 Rituximab in the Treatment of Interstitial Lung Diseases Related to Anti-Melanoma Differentiation-Associated Gene 5 Dermatomyositis: A Systematic Review CX3CL1 CXCR4 PMC8232320__F1 Monogenic Autoinflammatory Diseases: State of the Art and Future Perspectives CGAS SMS OTULIN MVK RNASEH2C RNASEH2B SHARPIN POLA1 NLRP3 TLR4 IL18 NOD2 TREX1 IL1B PMC3989450__F3 Wnt-dependent interactions between cardiac myocytes and cardiac fibroblasts after acute myocardial infarction SFRP4 WNT3A WNT1 SFRP1 CTNNB1 PMC5346041__F1 Major pattern recognition receptors (PRRs) that sense RNA and DNA virus pathogen associated molecular patterns (PAMPs) in the cytosol CGAS MAVS TRIM25 AIM2 IFI16 IRF3 HDAC6 PMC3989450__F2 Canonical Wnt signalling APC GSK3B LRP5 LRP6 CTNNB1 PMC4485953__F2 New Model of Reverse Cholesterol Transport: EnTICEing Strategies to Stimulate Intestinal Cholesterol Excretion PCSK9 ABCG8 ABCG5 ACAT2 NPC1L1 LDLR PMC3620567__F1 Ischemia-reperfusion injury in the diabetic myocardium is multi-factorial and complex BAD PTEN PMC10379778__F2 ARHGAP1 in Rho GTPase Inactivation during Metastasizing of Breast Cancer Cell Line MCF-7 after Treatment with Doxorubicin JUP CDC42 CDH2 APC IQGAP1 PTEN ARHA RAC1 CTNNB1 HEL114 MAGI1 FER SRC LEF1 PMC10379778__F1 ARHGAP1 in Rho GTPase Inactivation during Metastasizing of Breast Cancer Cell Line MCF-7 after Treatment with Doxorubicin CDC42 PARD6A SKIL SHC1 SOS1 SMAD2 BRAF ATF2 YY1 TRAF6 PDPK1 ROCK1 GADD45B CEBPB CDC2 RPS6 JUN SP1 APC SMAD6 ARHA RAC1 FOS TSC2 FZR1 MAP3K1 PAK1 MAP3K7 CREBBP MAP2K2 PMC6691199__F3 Proposed pathophysiological mechanisms that could explain the presence or absence of response to treatment in myocarditis RYR2 BAG3 PKP2 IL1B PMC9405832__F1 MTHFR SNPs (Methyl Tetrahydrofolate Reductase, Single Nucleotide Polymorphisms) C677T and A1298C Prevalence and Serum Homocysteine Levels in >2100 Hypofertile Caucasian Male Patients DHFR PMC5638334__F10 De novo transcriptome sequencing of Isaria cateniannulata and comparative analysis of gene expression in response to heat and cold stresses ARF6 ARHA CHMP3 PMC12065808__F1 Comprehensive network featuring genetic regulation and glucose, fatty acid, and glutamine metabolism in cancer ACLY FAS FH CD36 PC CS MTOR GLS2 MYC PMC4537692__F8 Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression PKD1 TFEB HDAC5 PMC9293965__F2 Clusters of significantly enriched biological pathways for AD and GERD ZNF582 TH ZNF2 PMC11791101__F3 Paracrine of the hedgehog signaling pathway BOC GAS FOXM1 NGF FGF7A KIF7 CCNE1 PTCH2 CCND2 SUFU BCL2 SMO GAS1 PMC11791101__F2 Autocrine of the hedgehog signaling pathway FGF7A FOXM1 CCNE1 KIF7 CCND2 PTCH2 BOC SUFU BCL2 SMO VEGFA GAS1 PMC11791101__F1 Normal activation mechanism of hedgehog signaling pathway EVC2 EVC KIF7 PTCH2 SUFU SMO GAS1 GLI3 PMC4344782__F9 Alzheimer-related protein association network in AD-iPS5 neurons COX7B NDUFB6 NDUFB2 NDUFB9 APOE NDUFV2 GSK3B SNCA ATP2A2 NDUFAB1 PPP3CC NDUFS4 COXFA4 SDHD SDHA SDHB PSENEN UQCRFS1 CASP3 CALM1 NDUFB7 APP NDUFB3 PMC6047437__F1 Genetic biomarkers of drug response for small-molecule therapeutics targeting the RTK/Ras/PI3K, p53 or Rb pathway in glioblastoma EGFR BRAF PTEN MTOR PRIMA1 PMC4631295__F2 Canonical Wnt signaling pathway APC CTNNB1 PMC5536816__F3 Benefits of physical exercise (PE) act through or require a healthy, functional endothelium (beige cells) SIRT3 COX2 VCAM1 BDNF CTNNB1 HEL-S-44 PMC6985271__F1 Type-I interferon signaling and ISG15 IFNAR2 USP18 IFNAR1 ISG15 JAK1 SKP2 TYK2 PMC9025460__F1 Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways SQOR PRODH DHODH PMC5088510__F3 Proteins modified by lysine methylation from the PhosphoSitePlus database were mapped onto the Kyoto Encyclopedia of Genes and Genomes (KEGG) prostate cancer pathway SRD5A2 CDK2 BCL2 PTEN MDM2 GRB2 MTOR CCND1 CTNNB1 PMC4129668__F1 Roles of PGs/GAGs on the breast cancer motile phenotype EGFR SRC PMC5342467__F9 RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation DMAP1 RGS6 ATM PMC8110983__F2 Tumour-derived factors associated with cachexia in pancreatic adenocarcinoma TH STAT3 POMC UCP1 NPY TLR7 AgRP MTOR TNF IL1B PMC10275075__F5 Population response of intestinal microbiota to acute Vibrio alginolyticus infection in half-smooth tongue sole (Cynoglossus semilaevis) FIGN FLI1 PMC7840052__F7 Chinese wolfberry and Astragalus extract on the antioxidant capacity of Tibetan pig liver PXMP2 MPV17 PEX19 PEX6 PEX2 PXMP4 PEX16 PEX10 PEX12 PEX13 PEX26 PEX14 PTS PMC7072125__F8 Molecular regulatory mechanism of Wnt/Beta-catenin signaling, induction of extrinsic apoptosis pathway by natural bioactive TA in NCCIT cells, and role of mROS in TRAIL-mediated extrinsic apoptosis induction with TA treatment TRADD SOX2 CTNNB1 PMC7072296__F2 Regulatory models of the Nrf2-ARE pathway induced by arsenic RBX1 KEAP1 PMC8071157__F4 MicroRNAs involved in aromatase regulation in breast cancer CTNNB1 TGFBR1 PMC8071157__F3 MicroRNAs involved in aromatase regulation in breast cancer MTOR NR5A2 CREB1 PMC8886228__F2 Metabolic Reprogramming, Gut Dysbiosis, and Nutrition Intervention in Canine Heart Disease CD36 HEL-S-5 PMC12227620__F8 Graphical representation of the working model CD44 DSG2 IL8RB CTNNB1 PMC2966484__F3 Activation of the NFKB signaling pathway RBX1 SKP1 PMC6206851__F1 Cellular Mechanisms of Estrogen Action FOXA1 EGF JUN GC FOS PMC6745301__F2 MicroRNAs and Regeneration in the Animal Models of CNS Disorders RHEB SMAD1 RICTOR DKFZp781O1323 PMC6383596__F2 Effector cytokines can stimulate transcription of proinflammatory signals through the Janus kinase–signal transducers and activators of transcription (JAK-STAT) signalling pathway JAK3 JAK1 TYK2 PMC2762102__F5 Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis ATR MCM7 ATRIP PCNA H2AX MCM3 ATM MCM5 MCM6 MCM2 PMC5038225__F1 IGF-1R downstream signaling cascades STAT3 IGF1 IGF1R MTOR IRS1 PMC3553500__F7 NleB, a bacterial effector with glycosyltransferase activity targets GADPH function to inhibit NFKB activation MAP3K7IP1 TRADD HEL-S-162eP TNF TRAF2 PMC9456096__F10 Metal Ion Periplasmic-Binding Protein YfeA of Glaesserella parasuis Induces the Secretion of Pro-Inflammatory Cytokines of Macrophages via MAPK and NFKB Signaling through TLR2 and TLR4 MAL TRAF6 MYD88 PMC2909548__F4 Protein-protein interaction maps comprising the transforming growth factor B signaling pathway of transcription factors associated with liver cell proliferation GNB2 PTP4A1 FHL2 ID3 ZNF331 ATF3 CREB3L2 DPF2 GDI1 ZNF3 CNOT3 NFKBIA CSK ATF4 PMC2909548__F3 Protein-protein interaction comprising the transforming growth factor B signaling pathway FBXO3 RHPN2 JUN COL1A2 PFN1 RAB34 CUL5 RHOBTB1 SQSTM1 RAB33B EFNA1 COL3A1 TGFBR1 PLEK STK35 RIPK2 TOB1 CHUK COL5A2 RRAS2 UBB PMC5507649__F2 Targeting the ALK signaling pathway STAT3 PTN ALK STRN PMC4516574__F5 An unexpected inhibition of antiviral signaling by virus-encoded tumor suppressor p53 in pancreatic cancer cells SOCS1 BAX STAT2 PSMB8 IRF9 IFIT1 IFITM1 IFIT3 IRF1 IFNG STAT1 PIAS1 JAK1 OAS1 TYK2 PMC6799822__F7 Signaling pathways contributing to mucus production CLCA1 MUC5AC SP1 EGFR HES1 PMC6531857__F4 Regulated necrosis: disease relevance and therapeutic opportunities LOX GLS GPX4 CTH HEL-S-64p HEL-75 PMC3862456__F3 Neutral AA transporters and activation of the mTORC1 signaling pathway RHEB TSC2 TSC1 HEL-S-5 IRS1 PMC6531857__F1 Regulated necrosis: disease relevance and therapeutic opportunities RIPK3 CSA2 MAP3K7IP1 TRADD MLKL RIPK1 IL1A TNF CYLD TRAF2 FADD PMC4204437__F1 Fanconi anemia (FA) proteins implicated in interstrand cross-link (ICL) repair RAD51C BRCA1 SLX4 PMC6913815__F1 An overview of the 3 unfolded protein response pathways ATF3 DBP ATF4 EIF2A XBP1 TRAF2 PMC8799033__F3 Identification of key biomarkers and potential signaling pathway associated with poor progression of gastric cancer COL1A1 COPE SPARC COL4A1 COL12A1 SPP1 PMC4938382__F2 Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas KLF4 TH SYK GLDN SPARC FOXS1 PCDHB1 RORA PPCDC PCDHA1 MEF2C ABAT GLRB IFNK GABRE NPTN MT1G ITK CARTPT CRHBP MT1A DMTN MEGF11 SORD IL13 APC FERMT2 VCAN BLK ACAN OMD FER ADRB2 SFTPC STC1 FAT2 PMC8799033__F6 Identification of key biomarkers and potential signaling pathway associated with poor progression of gastric cancer CD44 VWF CD36 CHAD CD47 PMC7601648__F1 Canonical NFKB signalling pathway induced by TNFA and IL-1B and the role of ubiquitination SOCS1 ING4 TRADD ITCH PDLIM2 RNF11 USP31 IRAK1 TRAF6 IRAK4 USP48 MYD88 SIAH2 USP4 USP20 USP21 TRAF2 CYLD TRIM23 PMC4160340__F2 Rho-GTPases as key regulators of T lymphocyte biology CDC42 ZAP70 ARHH PLCG1 BCL10 LAT APC VAV1 RHO GRB2 RAC1 LCK PMC3730427__F8 Glucose deprivation in cancer cells activates UPR following HBP flux reduction EIF2S1 BCL2 ATF4 XBP1 PMC4601190__F2 Epithelial cell recognition and discrimination of Candida albicans yeast and hyphae TF MTOR PMC11586749__F6 Analysis of classical signaling pathways and immune infiltration GATA2 ZNF143 STAT3 MYB SMAD1 LARP7 SMC3 PBX1 HIF1A SUPT5H TCF4 ATF2 TFAP4 MYC KDM4A STAT1 SOX9 ZBTB7A ASCL1 FGFR1 CCR7 TFAP2C NRF1 TBP CREB1 NR1i1 TCF12 SP1 SFPQ EZH2 IRF1 TCF3 FLI1 TCF7L2 tal-1 TP63 JARID2 CDK9 MAX BRD4 MAFK NR1H2 PGR RFX5 NFKB2 YY1 CDK8 CTCF FOXM1 SUMO2 POU2F2 CDK7 AHR CEBPB FOXA1 ACTG1 TFAP2A IRF4 BCL11A NFYB NR3C1 HDAC1 SETD1A CNOT3 NFYA KLF1 CREBBP EP300 FOXA2 BCL6 CHD2 EED CXXC1 RCOR1 TRIM28 TRIM24 E2F6 SNAI2 BATF RUNX1T1 ASXL1 ERG SMC1A BHLHB2 FOS RUNX3 NR2F1 RAD21 TIEG2 CEBPA CBFB FOXO1 TAF3 LMNA KLF4 BCOR CHD8 KMT2A RARA PBX3 HCFC1 MLL2 GABPA LEO1 DDX5 JUN EGR1 TLE3 PRDM11 SP2 BPTF MED1 TAF1 KDM1A TRIM25 NFKB1 MBD3 NIPBL KDM4C PMC7609400__F2 Extrinsic function of the PD-1/PD-L1 signaling axis in cancer ZAP70 CD80 LAT APC IL2 LCK PMC7444376__F3 GCN5 enhances the osteogenic differentiation of PDLSCs DKK1 LRP5 KREMEN1 LRP6 CTNNB1 PMC10571700__F5 Gene expression (CAMs) CD3D NCAM2 ZAP70 NRCAM EGF PDCD1 NFATC2 LAT EGFR PIK3CD AKT3 NRXN2 IFNG ALK ITGB8 NFKBIE BATF3 CNTN2 CD6 CDH2 NGL1 BATF2 CNTN1 CTLA4 FOS NRXN3 SPN ICOS TIGIT ITGAM CD3G CD8A CD3E SELP LCK PMC8557044__F1 Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury LOX STEAP3 GPX4 LPCAT3 SLC7A11 PMC7477662__F1 Main signaling pathways regulating autophagy TSC2 TSC1 PTEN PMC7659517__F2 Schematic view of M1 and M2 macrophage metabolism.Left side, M1 macrophage triggers a pro-inflammatory response ACLY ATF3 GLS CD36 MTOR PMC7659517__F1 Warburg effect likely supports replication of SARS CoV2 in airway cells.Enhanced aerobic glycolysis sustains the replication of many viruses in a similar way to the Warburg effect ACLY HEL-S-133P GLA ACE2 PMC6761220__F3 Strategies for immunomodulation to mitigate periprosthetic osteolysis induced by wear particles ARG1 CD163 IL1B MYD88 PMC4373664__F1 Canonical Rho GTPase signaling motifs regulate actin cytoskeletal dynamics CDC42 FMNL1 PAK1 ARHA RAC1 DAAM1 PMC4644376__F12 Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression LATS1 LATS2 TGFA EGFR AREG PMC6664079__F3 Potential targets for immune modulation during chronic progression of implant-related bone infections TIGIT CTLA4 LAG3 PMC10910037__F2 Crosstalk between NFKB signaling and other signaling pathways SYK CD79A TLR4 APC IL7R LYN CTNNB1 MYD88 PMC5285449__F1 Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis LATS1 LATS2 AMOT SCRIB RHO NF2 NOTCH2 PMC5422478__F4 Autoantibodies in the pathogenesis of Graves’ orbitopathy CD40 IGF1 TSHR IGF1R MTOR TNF IRS1 PMC7881399__F3 Sub-network including 12 hub-bottleneck nodes and two seeds of clusters 1 and 2 ALB GCG MUC5AC EGFR IL4 IL6 PTGS2 VEGFA TNF INS CXCL8 PMC7881399__F6 Action relationships including activation (green), inhibition (red), expression (yellow), and binding (blue) between the genes which were related to the determined biochemical pathways ALB MUC5AC EGFR VEGFA TNF INS CXCL8 PMC7881399__F5 Results of biochemical pathway analysis of hub-bottlenecks plus seeds of cluster-1 and 2 via ClueGO+CluePedia analysis ALB MUC5AC EGFR PTGS2 VEGFA INS CXCL8 PMC5858916__F7 Rotavirus infection TBK1 STAT1 BTRC MAVS STAT2 IFNAR2 IRF9 IFNAR1 IRF3 JAK1 TYK2 PMC5341901__F4 On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer FH GLS ERBB2 HIF1A MYC HEL-S-26 PMC5898751__F6 Phytohormone and MAPK signaling pathway TF MAPK6 PMC6539695__F7 EGF and TPA mediated pathway to phosphorylate serines in the SCFBTRCP recognition site of PDCD4-protein in Huh7 hepatoma cells EGF MTOR PMC7544845__F6 Druggable signaling cascades in vasculitogenic T cells ZAP70 IL2 PTEN HES1 NOTCH1 PMC7544845__F5 NOTCH signaling pathway in giant cell arteritis HES1 NOTCH1 PMC11872466__F10 KEGG pathway enrichment analyses of screened compounds in the treatment of AD TH BAD NUMB MTOR INS COX2 NOG APP HES1 HES5 LPL IDE CASP9 CASP12 APC LRP5 ATG14 NRARP SNCA TNF TUBB CDK5 RTN4 CASP3 NRBF2 MCU FADD PMC11567945__F1 Alterations of paracellular permeability in Alzheimer's disease (AD) patients and numerous AD models AQP4 ARHA MMP9 PMC4075250__F5 Ingenuity network analysis of differentially regulated labeled-pairs MAPK1 GRIN2B HEL-S-133P SLC2A4 ARF1 SNCA CNP MYC GDA LPO MBP HEL-S-69p SYT1 PMC5404269__F8 CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue JUN CYP2J2 ARG1 PMC5321202__F1 CORM-2 influences IBA-1- and GFAP-positive cells and many nociceptive factors and signaling pathways as measured on day 7 after CCI IL10 TIMP1 NLRP3 IL18BP PMC6539695__F4 Pathways of EGF mediated protein synthesis and PDCD4 degradation MTOR EIF4E PMC7862811__F1 PI3K/AKT signaling pathway activation and potential functions of LAPTM4B in cancers LAPTM4B CREB1 CCND1 PMC3402681__F1 Proposed mechanistic model on how SHARPIN regulates TNF-induced NFKB activation through linear ubiquitination-mediated mechanisms SHARPIN TRADD TAB3 RELA TNF TRAF2 PMC6212953__F1 Hepatitis C Virus (HCV)-induced oncogenic signaling STAT3 SRCAP EGFR SMAD2 APC SMAD4 SOCS3 PMC7881399__F2 Cluster-2 including 19 nodes and 111 edges GCG MLN NPS TSLP CCK GAS S100A8 CALCA INS PPY PMC7881399__F1 Cluster-1 including 24 nodes and 176 edges VIP CDKN2A LEP PYY CCL11 TLR4 EGFR PTGS2 VEGFA CXCL8 CCND1 GPT PMC8635784__F5 Low Molecular Weight Heparin Improves the Inflammatory State of Acute Sinusitis Rats Through Inhibiting the TLR4-MyD88-NFKB Signaling Pathway TLR4 IRAK1 IRAK4 MYD88 PMC2577715__F15 Notch, Wnt, and SHH signaling pathways APC SHH SMO CTNNB1 GLI3 PMC7701056__F1 PI3K/Akt/mTOR pathway RHEB TSC2 TSC1 PTEN PDK2 DEPTOR PMC4102824__F1 Flow diagram of the monoamine neurotransmitter biosynthesis pathway TH SPR MPG PNMT DBH PMC6386234__F1 Molecular pathways of cellular senescence CDC2 ATR CDK2 ATM MDM2 MTOR CDK4 PMC4588145__F1 Fish nucleic acid PRR signaling pathways TBK1 TLR3 TLR9 TLR8 DDX41 IRF3 IRF7 TLR7 MYD88 PMC7346763__F2 The transmembrane receptors for CSPGs and myelin-associated inhibitors and the signaling pathways downstream of two receptor protein tyrosine phosphatases (RPTPs) MAP1B APC ARHA PMC4348434__F2 Oxidative Krebs cycle GLS PC CS CPT2 PMC4098898__F2 Glutamate Metabolism and HIV-Associated Neurocognitive Disorders STAT1 IL16 PI3 CXCR4 PMC2864663__F5 Aging-related upregulation of NFKB signaling in VSMC RELB VCAM1 PMC2864663__F4 Aging-related upregulation of AP-1 signaling in VSMC JUN PCNA FOS PMC4685044__F1 Signaling pathways activated by cytokine receptor binding STAT3 MYC PMC5147022__F1 MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis AGO4 RAN DGCR8 AGO1 AGO2 DICER1 DROSHA PMC2930664__F1 One-Carbon Metabolism and Alzheimer’s Disease: Focus on Epigenetics RFC1 MTRR TYMS MTR PMC3518570__F2 Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease GDNF BMP2 BDNF FGF2 PMC6859457__F7 The HPV18 pathway regulates Tim-3/galectin-9 through EZH2-H2K27me3-DNMT3A HAVCR2 EZH2 LGALS9 PMC8042688__F1 Biological interactions among the formaldehyde-related genes, a hematological malignancies, and b cell processes HEL-S-22 CD40 FAS TGFB1 IL3 EPO PTEN CCL2 MPO HMOX1 IFNG F2R EPOR TLR4 IL18 IL2 ATM MDM2 IL1B BAX IL10 H2AX IL4 B2M IL17A PTGS2 VEGFA IL6 TNF PARP1 HRAS PRF1 CDKN1A CASP3 BCL2 TNFSF11 VCAM1 GSTT1 PMC4623426__F4 Regulation of Janus activated kinase (JAK)-Stat and nuclear factor kappa B (NFKB) signaling by TGFB through MKP-1 TF STAT1 TRADD SMAD2 TRAF2 PMC4623426__F3 Transforming growth factor B (TGFB) signaling pathways and aging TF SMAD2 SMAD4 PMC4623426__F5 Reciprocal regulation of TGFB and Jak-Stat signaling TF IFNG STAT1 PMC11643850__F4 Protective Effects of Pungent Flavor Components in Neurodegenerative Diseases COX2 ATF4 XBP1 PMC11643850__F3 Signaling of Wnt and calcium ions through MCOLN: CUR can activate Wnt signaling way by increasing the stability of Beta-cyclin, leading to its accumulation in the cytoplasm APC TFEB MYC CTNNB1 PMC11643850__F2 Signaling pathways for the neuroprotective effects of CAP and CB: CAP acts on TRPV1 and activates the PI3K/AKT/mTOR signaling pathway, enhances the phagocytosis of microglia, and activates the promoter of BDNF TRPV1 MTOR BDNF PMC4222256__F8 Supposed mechanism of EVE-induced EMT PRR5 RHEB MLST8 HPSE TSC2 RICTOR TSC1 MTOR PMC3108840__F7 Functional pathway analysis of glycoproteins overexpressed in PC3-ML2 JUP POSTN PNN MAVS HACL2 INA hEMMPRIN PCDHJ SLC14A2 PMC3108840__F6 Functional pathway analysis of glycoproteins overexpressed in PC3-N2 LCP1 PALM TEX10 CTNND1 STT3A NUP188 PRPF40A CD55 HM13 SEC24C RNF213 PMC6689970__F1 Schematic overview of NAD biosynthesis pathways NNMT NRK NAPRT NAMPT PMC9554879__F5 Immunogenic cell death related risk model to delineate ferroptosis pathway and predict immunotherapy response of patients with GBM ELL INS SET PMC2270353__F4 NPTX2 pathway obtained by means of the Resnet 5.0 eukaryotic database of molecular interactions (Ariadne) overlayed with microarray expression values NPTX1 GRIA3 GRIA2 GRIA4 NPTX2 NPTXR PMC6114477__F1 Tumor-associated macrophages and epithelial-to-mesenchymal transition in hepatocellular carcinoma CDC42 CDH2 STAT3 EGF NTS SMAD2 GSK3B SMAD4 MMP9 ARHA CTNNB1 NR2A1 CXCR1 FOXC1 ZEB2 PMC4784721__F1 Major AGTR1 signalling pathways linked to cancer cell proliferation, angiogenesis and EMT BCL10 EGFR GRB2 PMC6114477__F5 Virus-related products in the inflammatory tumor microenvironment STAT3 COX2 GSK3B MMP9 IGF2 PMC6114477__F4 Inflammatory mediators in hepatocellular carcinoma MMP16 LOXL2 PI3 SMAD2 CXCL1 MMP2 MMP9 CXCL10 PMC9214699__F5 Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma PPP1CC PIK3CD PIK3R2 PIK3R1 PRKAG2 PRKCZ SOCS2 PHKA2 MAPK9 ACACA SOCS3 PCK1 PRKAA1 MAPK3 HEL-S-80p PPARGC1A PRKAR1A RPS6 EIF4EBP1 PYGB CRKL ID1 HRAS PCK2 RHEB ACACB PRKCI FOXO1 PRKAG1 FBP1 CALM1 PRKAB1 MAP2K1 PMC6214858__F7 Schematic flow diagram of signal transmission from regulatory factors secreted by TM4 cells to ADSCs EGF TGFB1 SOX2 ELL MDM2 PMC5508315__F2 Direct, indirect and semidirect pathway of allorecognition CD44 APC PMC6747268__F4 Signaling pathways involved in the switch between proliferation and dormancy RHEB MTOR CDK4 PMC5508315__F1 Mechanism of regulatory T cell (Treg) suppression CD80 IL10 APC PMC8569813__F2 Colon Cancer Progression Is Reflected to Monotonic Differentiation in Gene Expression and Pathway Deregulation Facilitating Stage–specific Drug Repurposing CLCA1 TMEPAI F2 PPARGC1A SLC26A2 TACSTD2 PMC9379408__F10 Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells GLTPD1 SP1 SP3 PMC11793009__F9 Potential regulation loop of MET and ETS collaboration HGF AREG CXCR4 PMC5506222__F4 Schematic model showing AA sensing signaling pathways that might modulate neuronal activity of central olfactory areas CASR SLC3A2 SLC12A5 TRPM5 SLC7A5 PMC6289335__F1 Molecular actions of CTLA-4 and PD-1 on inhibiting T cell function CD80 PTEN PPA2 MTOR PMC6877505__F1 Schematic view of microglial activation and cross-talks between microglia and other immune factors in the pathogenesis of Parkinson’s disease IGF1 SOCS3 BDNF CCL2 CCL20 IL1B PMC3191464__F2 Model depicting the pathway of TGFBeta-mediated Bim regulation and apoptosis RUNX1 FOXO3A SMAD4 PMC8672524__F7 Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction INCENP KNTC1 ZWINT CENPA CCNB1 PMC2727921__F1 Genetic polymorphisms, their allele combinations and IFNB treatment response in Irish multiple sclerosis patients IFNGR1 LEP STAT2 IRF9 PNPT1 IL10RA GBP1 STAT1 IFNGR2 EBI3 IFNAR1 PRKCA PIAS1 CASP3 IL23R TYK2 IL10RB IL12RB1 PMC6420874__F1 Mechanisms by which radiation enhances immunotherapy HMGB1 CGAS SIRPA CD47 PMC3122316__F1 F igure 1.— HEL-S-70p ADSL PMC8495383__F3 Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment TLR4 ELF2 MAPK7 ERBB2 ENO1 PIGR MEF2C PMC4223001__F1 Harnessing Hippo in the heart: Hippo/YAP1 signaling and applications to heart regeneration and rejuvenation LPA AMOT RHO NF2 SRC CTNNB1 PMC7312732__F6 Activation of the TRPV1 ligand-gated ion channel and subsequent [Ca2+]i and protein signaling influence the balance between proliferation and apoptosis NGF EGFR TRPV1 ATM ATF4 XBP1 RAC1 UNK PMC6769685__F5 Apoptotic pathways triggered by inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors MTOR SRC PMC7407888__F1 Scheme illustrating the IL-10 signaling pathway STAT3 SOCS3 TYK2 PMC9478028__F3 Hepatitis B virus DNA integration as a novel biomarker of hepatitis B virus-mediated pathogenetic properties and a barrier to the current strategies for hepatitis B virus cure ESPL1 CCNE1 TERT CCNA2 SET CTNNB1 PMC3396155__F5 The balance in signalling through either ALK-1 or ALK-5 regulates leptin expression in MSC SMAD1 DKFZp781O1323 SMAD2 PMC7312732__F2 TRPV1 induces proliferation through Ca2+ entry, ATP release and membrane P2Y2 receptor activation, and the transactivation of epidermal growth factor receptor (EGFR) EGFR TRPV1 PDK2 SRC PMC8583859__F2 Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy NLRP3 COX2 CD36 TLR4 IL1B PMC8531643__F1 Aberrant Metabolism as Inductor of Epigenetic Changes in Breast Cancer: Therapeutic Opportunities JMJD4 FASN MTOR SUV39H1 PMC7518150__F5 Molecular mechanism of Wnt/Beta-catenin signaling pathway activation APC GSK3B LRP5 LRP6 CTNNB1 PMC3918842__F2 Pathways for the synthesis of phospholipids and their interconnection PSD PEMT PC PCYT2 PMC5828202__F10 Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca2+-CaMKII-Sp1 pathway SP1 ATF4 EIF2A PMC5468621__F5 Summary of signaling events and downstream transcription factors driving specification of the blood stem cell lineage GATA2 HHEX ETV2 NOTCH1 PMC8964100__F8 Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway STAT3 COL1A1 BLM PMC6093060__F7 NFKB inflammatory signaling pathway IL16 TLR4 MYD88 PMC8876671__F3 SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance MAML1 SALL4 HEY2 SOX2 MEIS1 NOTCH3 HES1 PMC5481366__F1 Estrogen biosynthesis HSD17B1 HSD17B2 HSD17B7 SULT1E1 STS HSD17B12 PMC3875949__F1 Regulation of metabolism in maligant gliomas ACLY FAS GLS HK2 HEL-S-162eP EGFR PMC5811730__F4 Distinct mechanisms of small-molecule inhibitors and monoclonal antibodies for targeting receptor tyrosine kinases in cancer cells EGF EGFR CR2 GRB2 CR1 PMC8666372__F3 Activated and inactivated canonical Wnt signaling SFRP5 DKK1 APC LRP5 LRP6 WIF1 PMC5811730__F3 Rationale for targeting both the Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt/mTOR pathways for suppressing cancer growth BAD RAI1 EGFR MDM2 GRB2 MTOR SHE PMC8666372__F1 Activated and inactivated canonical Wnt signaling APC LRP5 LRP6 PMC8876671__F2 SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance BMI1 SALL4 PTEN PMC8876671__F1 SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance BMI1 SALL4 WNT3A TCF4 TRIB3 CCND1 AXIN2 CTNNB1 PMC8231959__F1 Coenzyme Q Biosynthesis: An Update on the Origins of the Benzenoid Ring and Discovery of New Ring Precursors FDX2 COQ7 IPP FDXR COQ3 COQ2 FDX1 COQ6 RHO COQ5 PMC3342071__F2 FcERI signaling events in WT, NTAL−/−, and LAT−/− cells LAT LYN GRB2 GAB2 PMC8920690__F1 Nervous System Contributes to the Tumorigenesis and Progression of Human Digestive Tract Cancer IGF1R SRC PMC5905346__F1 GCs stimulate GSK3ß and inhibit Wnt signaling APC GSK3B LRP5 LRP6 CTNNB1 PMC7927137__F5 Circadian clock machinery regulates the biosynthesis of NAD+ through control of the NAD+ salvage pathway NAMPT SIRT1 PMC2744278__F3 Phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways BAD GSK3B PTEN MDM2 GRB2 MTOR PMC6041767__F2 Example module (L1) more densely connected in ER- group with red nodes indicate genes belonging to the immune response pathway RASSF2 HEL113 SPARCL1 HEL-S-81p GEM CD69 IL33 TMEM100 APOL3 CD83 SLIT2 ALOX5 DPT PROS1 PSMB10 ITM2A FXYD1 LAT2 SPRY1 FCGR2A CXCL13 SAMSN1 BACH2 C1S CFH CLEC10A ANXA1 VAV1 PTPN6 SFRP1 HLA-DMA FBLN5 IGSF6 CD3E PMC2830970__F1 Schematics of the retroviral replication cycle CCR5 CXCR4 PMC6084457__F1 Metabolic pathways contributing to HSC self-renewal and differentiation VIT HEL-S-133P HEL-S-5 PTPMT1 BCAT1 CPT2 MYC HEL-S-26 PMC10138908__F7 Which OBHS remodels abnormal glycometabolism, referring the experiment results HEL-S-68p ENO1 PMC6782151__F11 Mechanism of microglial activation by fibrillarBA and PrP peptides responsible for neurotoxicity SYK LYN GRB2 PMC1134761__F4 Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit CA4 APC NET1 PMC7281073__F1 PI3K/AKT/mTOR pathway activation leads to cell growth, increased protein synthesis, inhibited apoptosis, cell cycle progression and proliferation FANCD2 BAX BAD EGFR PTEN MDM2 CCND1 PMC3625357__F11 IPA-generated gene network linking 88 of 445 genes shown by microarray analysis to be significantly (P < 0.01) up- (blue) or down- (red) regulated >twofold in bovine TCs in response to BMP6 treatment MYB ADAMTS4 MGST1 MRC2 BNIP3 CCL5 LHCGR FGFR2 FOXO4 INHA FBLN2 HES1 CDH2 NOS2 SNAI2 ID2 HEL-S-133P SERPINA3 PLAUR VEGFA BHLHB2 VCAN HMGCS1 ANGPTL4 GPAM FBLN5 ECE1 HPGD HSD3B1 EDN1 EDNRA SERPINB2 AKAP12 CCL20 TES KLF4 KRT18 DHCR24 INSL3 NEDD9 ABCA1 NCAM1 PLAT ARFGAP3 PLAGL1 SHBG RND1 IL1B LTBP2 HEL-S-101 BEX2 STAR NGFR FASN NR5A1 PTGS2 IL6 CLEC3B ID1 ID3 AKAP5 SERPINE2 CYP11A1 ZBTB16 TM4SF1 PMC10383966__F4 Pellino Proteins in Viral Immunity and Pathogenesis IRAK1 IRF3 IRF7 IRAK4 MYD88 PMC5445144__F4 Regulatory T cell (Treg) action mechanisms CD80 CTLA4 LAG3 PMC10383966__F1 Pellino Proteins in Viral Immunity and Pathogenesis TBK1 GSDMD MAP3K7IP1 TAB3 IRAK1 IRF3 IRF7 TRAF6 IRAK4 MYD88 PMC7473936__F12 Vascular permeability disruption explored in the proteomes of mouse lungs and human microvascular cells following acute bromine exposure CDC42 PAK1 LIMK1 RHOB HEL70 ARHA RHO DMPK RHOV RAC3 RAC1 PMC7246454__F1 DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension TOPBP1 ATR BRCA1 ATM PMC3248879__F1 Network images of FTO and candidates genes PREPL VAMP2 STX12 CBX6 USP34 NTRK2 PTEN PPP2R1A SSBP2 NICN1 GLRB NLN CDR2 USP2 KIF3C PFN2 CAMK2G PMC9680067__F4 Teleost NOD-like receptors and their downstream signaling pathways: A brief review STAT3 NLRP3 NLRC3 MTOR VEGFA TRAF6 PMC3248879__F4 In silico analysis and gene expression studies suggests functional coupling between FTO and the BDNF/NTRK2-signalling pathway EGR1 EGR2 BDNF CEBPB FOS PMC9680067__F6 Teleost NOD-like receptors and their downstream signaling pathways: A brief review NLRP1 NLRP12 LTA NLRP6 NLRP3 IL18 IL1B PMC9680067__F3 Teleost NOD-like receptors and their downstream signaling pathways: A brief review MAVS NOD2 IRF3 IRF7 NOD1 PMC8339999__F9 Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NFKB Axis TH NLRP3 MYD88 PMC4468292__F1 Influence of the inflammatory cytokines on the status of insulin resistance STAT3 TLR4 IRS1 PMC5704542__F8 Model for regulation of nitrogen availability response RPS6 EIF4B PMC9483726__F3 Comprehensive elaboration of circular RNA in multiple myeloma MAPK4 HDAC1 BRD4 CDK6 AKT3 ATG14 ABCG2 SKP2 PMC2824707__F1 Tissue level and signalling pathways for PGE2 is presented COX1 EGFR CTNNB1 PMC5207147__F13 Proposed model on the cross-talk between HGF/c-Met and SphK1/S1P/Spns2/S1P1signaling axis in HGF-mediated lamellipodia formation SPNS2 HGF SPHK1 PMC4373397__F2 Mucosal barrier integrity and inflammation IL25 MLN TSLP IL33 CCL2 IL1B PMC4440219__F7 MiR-503 mediates constitutive suppression of the IGF-1R pathway leading to a less aggressive glioma phenotype BAD CCNE1 IGF1R CCND1 PMC8256367__F3 How Transmembrane Inner Ear (TMIE) plays role in the auditory system: A mystery to us TMC1 TMC2 TMIE PMC8608616__F4 Redox regulation of DUBs and its therapeutic implications in cancer STAT3 TSC2 USP28 TGFA PHLPP1 USP19 USP1 USP11 PTEN CYLD IGF2 IL1B PMC3460412__F1 Activation of p38 MAPK downstrem of TNFR1 TRADD TRAF5 TNF TRAF2 PMC1867237__F3 ErbB/Ras pathway and Wnt pathway WNT10B DVL1 APC GSK3B ERBB2 MYC CTNNB1 PMC4872445__F2 Distinct roles of enzymes MTHFD1L and MTHFR in the folate-related one-carbon cycle MTHFD1 MTHFD1L PMC6028513__F2 TRIMming TGFB signals in Th17 cells SMAD2 SMAD4 FOXP3 PMC5488350__F1 The Taste of Caffeine TRPM5 PLCB2 CALHM1 PMC2886325__F3 PI3K-Akt-mTOR pathway and cross-talk with other signaling cascades: (Ras/Raf/MAPK and BCR-ABL) EGF TSC2 TSC1 IGF1 PTEN MTOR PMC3319521__F1 The CD47-SIRPA Pathway in Cancer Immune Evasion and Potential Therapeutic Implications SIRPA CD47 PMC4971811__F7 Proposed model for increased IL-6 and leptin production caused by global Zip14 deletion STAT3 TIRAP TLR4 IL6 TRAF6 MYD88 PMC8396208__F3 GDF15 and Cardiac Cells: Current Concepts and New Insights FOXO3A GDF15 MSC PMC8396208__F2 GDF15 and Cardiac Cells: Current Concepts and New Insights ALK OPA1 FGF21 GDF15 BMP2 MSC GFRAL CREB1 PMC4940573__F1 Strategies for modulating the BMP pathway SMAD1 SMURF1 DKFZp781O1323 PMC3875463__F1 MTOR pathway and epilepsy RHEB PIK3CA AKT3 PTEN EIF4E PMC7751413__F1 P53 signaling pathway of the large yellow croaker (Larimichthys crocea) responds to acute cold stress: evidence via spatiotemporal expression analysis of p53, p21, MDM2, IGF-1, Gadd45, Fas, and Akt RFWD2 TSC2 FAS CASP8 CDK6 SIAH1 PTEN MDM2 MTOR CDK4 PMC5217378__F6 Ingenuity Pathway Analysis showing the top molecular network in HSPC-derived myeloid cells collected at 6 months after exposure of mice to 0.25 Gy of 48Ti ions EIF4EBP3 GPR37L1 DUSP8 AGPS LAD1 SUPT20H INS KRT75 NRG4 EIF4E RB1 GBP5 KRT34 VAMP5 EPGN TNFSF11 GRB2 DUSP7 PMC9136582__F1 Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy TAOK1 TAOK2 ATF2 RHO GRB2 MEF2C PMC4295939__F8 Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3 PNKP BAX PC ATM PMC5217378__F7 Ingenuity Pathway Analysis showing the top molecular network in HSPC-derived myeloid cells collected at 6 months after exposure of mice to 0.5 Gy of 48Ti ions RPL35 CCNE1 HEL-S-2a NOP56 RPL38 SND1 RPL6 PMC2665873__F1 Fatty acid synthesis pathways in C FAT4 FAS FAT1 FAT2 FAT3 PMC5217378__F2 Ingenuity Pathway Analysis showing the top molecular Network in HSPC-derived myeloid cells collected at 1 week after exposure of mice to 0.1 Gy of 48Ti ions PRR12 VPS13D ABRACL CNDP2 UBC NDUFC2 TMED7 FAM136A ADPGK NANS TMX4 COLGALT1 GSDMD TSFM SF3B5 TMEM85 HINT2 NCLN GORASP2 DMXL1 ZNF407 NAA38 NOMO1 PMC6747541__F3 Syntenin-mediated signaling in the regulation of membrane structure and cell motility CDC42 MMP2 ARHA SRC CD63 CD6 PMC6890838__F3 Mutant proteasomes from CANDLE/PRAAS subjects have a potential pro-inflammatory potential due to the negative impact they exert on mTORC1 TBK1 IRF3 ATF4 EIF2A SESN2 DEPTOR PMC6890838__F2 Defective proteasomes in CANDLE/PRAAS subjects provoke ER stress and trigger the so-called unfolded protein response (UPR) which is associated with inflammation TBK1 MAVS IRF3 ATF4 EIF2A PMC9618966__F6 Macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer JUN LTA TLR3 MVP IRF3 MYC RAC1 FOS MYD88 PMC3095999__F2 Literature-based connections among genes in altered modules of head and neck squamous cell carcinoma (HNSCC) POSTN INHBA EGFR SERPINA3 SPHK1 AREG MMP9 MYC CCL20 IL1B PMC7321691__F1 RT activates the IFNs-JAK/STAT1 pathway in cancer cells CXCL9 ENO2 PLSCR1 IFIT1 IFIT3 IFIT2 IFNG ALDH2 STAT1 IFI44 USP18 MX2 MX1 OAS1 JUN STAT2 IRF9 IFITM1 IRF1 CXCL10 FOS IFIT5 EN2 ENO3 EN1 ENO1 IFI27 JAK1 HEL-S-87p TYK2 PMC8268006__F1 Beyond RAS and BRAF: HER2, a New Actionable Oncotarget in Advanced Colorectal Cancer STAT3 PIK3CA EGFR BRAF MTOR PMC5078854__F1 Metabolic pathway of citrate and isocitrate on the citric acid cycle in the mitochondrial matrix and in the cytosol HEL60 ACO2 HEL-S-26 PMC6363433__F2 Folate decomposition and damage repair DHFR SHMT1 HEL-S-70p MTHFS PMC11074409__F2 Activity of probiotics, synbiotics and postbiotics IFNG BAX IL10 COX2 IL4 BCL2 IL6 CTNNB1 PMC2577687__F1 Metabolic scheme MAL PC CIT PMC11731763__F9 Signaling pathway of LH resist apoptosis and promote proliferation of freeze-thaw folliculars and granulosa cells by TGFB and its superfamily members BMP15 FOXL2 GPR49 GDF9 PMC3375400__F1 Comparison of the pathways responsible for the anti-apoptotic and pro-apoptotic effects of immune complexes containing oxidized LDL (oxLDL-IC) and malondialdehyde-modified LDL (MDA-LDL-IC) SYK BAD CD36 PMC7555004__F3 Some proposed mechanisms of aging involving xanthine oxidoreductase (XOR) and its products CDC2 NLRP3 ATM MTOR SIRT1 IL1B PMC8533761__F1 Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation? PDK4 F2 PMC11970819__F1 Pathophysiology and emerging therapeutic targets of IBD APC IL21R IL23R RUNX3 PMC2613125__F6 Interleukin-6 and Neural Stem Cells: More Than Gliogenesis CNTF EGF NGF BDNF PMC8059031__F3 ncRNA regulatory network map of acute myocardial infarction TUG1 PMC2528847__F2 Integration of genomic and nongenomic/rapid ER signaling and its crosstalk with growth factor receptor and cell kinase pathways in endocrine resistance: a working model TF HBEGF EGFR PMC4157971__F7 Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: a critical role of the Notch1–NFKB pathway in BMP-2 expression TLR4 BMP2 NOTCH1 PMC7191956__F5 Tomatidine-targeted genes-related part of the top five shared KEGG pathways BOLL RPS6KA2 RPS6KA1 RPS6KA3 MAP2K1 MAP2 FOS PMC7388413__F1 The PI3K pathway in cancer cells PI3 EGFR MTOR PMC7312293__F2 Key negative and positive regulators for NLRP3 inflammasome UCP2 GPR132 NLRP3 PC FABP4 SPTLC1 CPT1A NOX4 PMC9248759__F6 Is Estrogen a Missing Culprit in Thyroid Eye Disease? Sex Steroid Hormone Homeostasis Is Key to Other Fibrogenic Autoimmune Diseases – Why Not This One? IGF1 IGF1R PMC8787213__F2 Research Advances in Multi-Omics on the Traditional Chinese Herb Dendrobium officinale UGDH XK UXS1 FRK PMC4415653__F6 Genetic regulatory network based on published interactions SP1 RXRA RELA ATF4 PMC8787213__F1 Research Advances in Multi-Omics on the Traditional Chinese Herb Dendrobium officinale IPP UGT8 MVK PMC5715731__F9 Model illustrating the intracellular signaling pathway leading to cell proliferation and survival in response to NRG-1B treatment ERBB3 GSK3B ERBB2 BDNF PMC8115506__F1 Excess levels of cytoplasmic TDP-43 lead to mitochondrial penetration of TDP-43 which may trigger mtDNA release with ensuing activation of the cGAS/STING immune sensor TBK1 CGAS F2 IRF3 TNF PMC7768821__F9 Possible mechanism(s) of suppression of alcoholic hepatosteatosis by physcion NR1C1 NLRP3 IL1B PMC4415653__F3 SP1, JUN and STAT1 subnetwork from the Brown module STAT1 JUN SP1 COPS5 TPM3 WDHD1 ATF4 NACA PMC6517835__F9 Foxi3 inhibits epithelial differentiation and promotes suprabasal cell formation SFRP5 NOTCH2 FOXI3 PMC7054714__F5 Immune Responses to Viral Gene Therapy Vectors CGAS HEL-S-62p MTOR IL1B PMC8801025__F3 Organoids to model the endometrium: implantation and beyond EGF WNT3A FGF10 PMC7054714__F3 Immune Responses to Viral Gene Therapy Vectors CD40 IFNG CD80 PDC IFNAR1 TLR9 IL1B MYD88 PMC6633015__F8 The signaling pathway mediated by GABAB receptor in CGN neuroprotection IGF1 PI3 IGF1R SRC PMC6123661__F8 Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models TIAM1 RAC1 FUZ PMC3138369__F1 Signaling pathway for epidermal growth factor receptor (EGFR) EGFR PTEN GRB2 MTOR KIN PMC4322317__F6 Protein Complex Discovery by Interaction Filtering from Protein Interaction Networks Using Mutual Rank Coexpression and Sequence Similarity ZNF558 DIS3 LRRC8D SMPD4 EXOSC4 EXOSC1 EXOSC5 IP6K1 NUP160 EXOSC3 PMC8615581__F2 Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies IPP KEAP1 GPX4 LPCAT3 FACL4 PMC9375325__F2 PI3K/AKT pathway in squamous cell carcinoma with an especial focus on head and neck cancers LTBP2 CDH2 BAX BAD ITGB4 LAMC2 GSK3B FLJ10842 PTEN EFNA3 FBXW7 FOXO1 PDPK1 PMC6887790__F4 Biochemical pathway in neutrophils showing the signaling cascade and the effects related to DAG and PA activation CXCR1 IL8RB CXCL8 PMC9375325__F1 PI3K/AKT pathway in squamous cell carcinoma with an especial focus on head and neck cancers CDH2 BAX GSK3B PTEN ATF2 MTOR DEPTOR RHEB MLST8 TSC2 TSC1 MMP2 MDM2 PMC4151153__F2 Toll-like receptor 4 (TLR4) signaling pathway by Lactobacillus casei OLL2768, Bifidobacterium adolescentis MCC-75, and Bifidobacterium adolescentis ATCC15705 in bovine intestinal epithelial epitheliocytes (BIE cells) JUN TLR4 CD14 SIGIRR IL4 IRAK2 FOS PMC7297493__F1 Schematic representation of the hypothesized downstream pathways to ASCL1 and MYT1L during transdifferentiation ASCL1 MYT1L KMT2B PMC2691592__F7 Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-Induced Apoptosis HUS1 CLK2 PMC9167730__F3 TLR-dependent signaling pathways are modulated by allosteric activation of CD11b SYK FOXO3A IRF3 SRC MYD88 PMC9322956__F1 Computational Methods in Cooperation with Experimental Approaches to Design Protein Tyrosine Phosphatase 1B Inhibitors in Type 2 Diabetes Drug Design: A Review of the Achievements of This Century ERBB3 STAT3 ERBB2 GRB2 SRC IRS1 PMC3156870__F1 Resistance to RAF inhibitors in melanoma AKT3 BRAF PTEN BMF IGF1R CCND1 PMC7415163__F1 Complement activation pathways and narsoplimab mechanism of action HEL-S-62p C2 C1S C1R PMC11790847__F1 Multiple post-transcriptional modifications regulate cancer progression via manipulating the activity of the Hippo signalling pathway LATS1 LATS2 B4GALT1 USP12 YTHDF2 METTL3 PMC10312162__F4 Changes in the metabolic pathways of young and old leaves in the two soybean ecotypes MALL F2 PMC3534236__F3 Autophagy and selective deployment of Atg proteins in antiviral defense TLR1 TLR3 TLR9 TLR7 ATG5 PMC11853365__F1 Multifaceted roles of ApoE4-induced Glial dysfunction in Alzheimer’s disease pathology NLRP3 IL6 PMC7244030__F8 LOC646616/miR-637/WNT3 ceRNA network in EH CAMK2N2 WNT3 CTNNB1 PMC7243138__F2 Pin1-mediated APP processing GSK3B APP PIN1 PMC6755804__F4 Selection of enriched pathways and genes and their involvement in various tumorigenic pathways BRWD3 PPARG RASSF2 HIVEP1 PITX1 WDR11 MAP3K8 NGF FOXO4 CD74 SMO CNTRL DPPA2 TRIP11 FOSB LAMC2 CXCL14 SATB1 RANBP2 RBX1 TIAM1 ARHGEF4 PTCH1 ZNRF3 PSAP HEL-S-22 STAG2 FDXR RASSF1 NPY1R EGFR CXCL1 HTRA1 TERT RHO MTOR COL9A3 ARMCX1 LFNG S100A14 ETS2 BRD3 OSGIN1 NGFR DMBT1 LDB1 GATA3 NR1C1 FRAT2 RPRM P4HA1 DHRS3 CTCFL PMC12071403__F6 Correlation between stress-mediated inflammation and major depression CYP24A1 SLA ZNF729 IL3 DDIT4 NTRK2 MTOR PRKAA1 UGT8 ID3 HDAC1 RPS26 EIF4EBP2 PMC6349770__F2 Implementation of metabolic engineering strategies in S HEL-S-162eP XDH PMC9363121__F7 Possible model of Banp functions in stalled fork recovery, DNA damage repair, and chromosome segregation during mitosis WRNIP1 ATR BANP NCAPG ATM PMC12071403__F4 Inflammatory Factors: A Key Contributor to Stress-Induced Major Depressive Disorder LTB TRAF4 PLCG1 BCL10 RELB TRAF5 TRAF1 TRAF3 TRAF6 TRAF2 PMC5550428__F6 Regulation of ΔF508 CFTR stability by inhibitors to the PI3K/Akt/mTOR pathway BAG3 HSF1 CFTR PMC6755804__F5 Network of pathways and genes induced by P152Lp53 expression RASGRP4 NGF RAMP2 GOLGB1 FRAT2 EGFR RHO MTOR PSAP PMC7467273__F2 Genome-wide analysis of DNA methylation in testis of male rat exposed to chlorpyrifos POR ZAP70 BAD RAD1 LAT MAK PLEC APP MB RHO PMC6292568__F2 Candida–streptococcal interactions in biofilm-associated oral diseases PMC11581872__F8 Huyang Yangkun formula regulates the mitochondria pathway of ovarian granulosa cell apoptosis through FTO/m6A-P53 pathway BAX MCL1 CASP3 METTL14 BCL2 METTL3 PMC11676253__F1 Anti-Müllerian Hormone (AMH), signaling pathway in granulosa cells AMHR2 AMH FSHR PMC8654699__F6 Targeting SOS1 overcomes imatinib resistance with BCR-ABL independence through uptake transporter SLC22A4 in CML SLC22A4 RAF1 SOS1 PMC7237910__F3 Spiking Pandemic Potential: Structural and Immunological Aspects of SARS-CoV-2 TMPRSS2 HEL-S-69p ACE2 PMC6671871__F1 Lignin biosynthetic pathway CAD JCAD PMC4550414__F5 Network Topologies Decoding Cervical Cancer MTOR VEGFA CCND1 CDK4 PMC5923480__F2 Feline restriction factors and FIV counteraction mechanisms SERINC3 CXCR4 PMC8348676__F2 Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis BAX FAS EIF2A PMC8348676__F1 Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis TLR4 ATL3 MTOR ZC3H4 MYD88 PMC2173691__F7 Mechanisms of E-cadherin regulation in sparse and dense cultures of colon cancer cells CAD ERBB2 CTNNB1 PMC7338763__F1 What Matters for C4 Transporters: Evolutionary Changes of Phosphoenolpyruvate Transporter for C4 Photosynthesis MAL GC CS PMC8784274__F3 Transcriptomic Analysis Reveals a Link Between Hippo Signaling Pathway and Macrophages in Lungs of Mice with OVA-Induced Allergic Asthma WNT3A GSK3B BBC3 MYC WNT2B WNT5B FRMD6 BIRC5 WWTR1 FZD8 CRB2 WNT4 BMPR2 PPP2R2C SNAI2 APC AREG BMP6 PRKCI FZD4 PARD3 BMP5 WNT10B FZD5 RASSF1 LAT APC2 TEAD4 MOBKL1A LATS2 TEAD2 AMOT BMP4 WNT7A WNT9A FZD1 HEL2 NKD1 CCND3 CRB1 NKD2 SOX2 AXIN2 ID1 PARD6G WWC1 PARD6B BMP2 SCRIB AJUBA LEF1 PS1TP5BP1 PMC7005212__F4 Compound-potential targets-disease network (Blue diamond represents compound target; red circle represents pathway; purple hexagon represents disease) RELA ACD PTGS2 TNF MAOA PMC8278527__F7 SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/Beta-catenin signaling SFRP5 APC GSK3B LRP5 LRP6 CTNNB1 PMC5388917__F5 Regulation of Akt signaling pathways after (A) vehicle, and (B) melatonin treatments following ischemic-stroke BAD GSK3A GSK3B PTEN MTOR PMC9218606__F4 Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress KEAP1 NQO1 GCLC HEL-S-44 PMC9506554__F1 Genetic Variants in One-Carbon Metabolism and Their Effects on DHA Biomarkers in Pregnant Women: A Post-Hoc Analysis MTHFD1 PEMT SHMT1 HEL-S-61p PMC3497272__F2 ErbB signaling and inhibition in tumour cell ERBB3 STAT3 BAX BAD ERBB2 BCL2 GRB2 GAB2 PMC5769965__F10 Cocaine and HIV-1 Tat Disrupt Cholesterol Homeostasis in Astrocytes: Implications for HIV-Associated Neurocognitive Disorders in Cocaine User Patients APOE LDLR ABCA1 PMC2732569__F2 The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics PINK1 FIS1 OPA1 AFM PMC2097959__F2 INTEGRATING RADIOTHERAPY WITH EGFR ANTAGONISTS AND OTHER MOLECULAR THERAPEUTICS FOR THE TREATMENT OF HEAD AND NECK CANCER COX2 EGFR GRB2 MTOR PMC5143322__F1 AHR signaling pathway JUN RELA PRKCA AHR PTEN PMC5768915__F1 HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway STAT3 SOX9 LEPR SOX2 FGFR2 PMC4113076__F7 Comprehensive and High Resolution Genome-wide Response of p53 to Stress OGT PCNA UTP3 SDC4 MED21 XPC GATC DDB2 TRAF4 RAD51C RARA MTBP FTL PLK3 ABCD3 KDM5C RRM2B MDM2 SESN2 SDF4 RBM14 PMC3932967__F2 Role of Notch signaling in the mammalian heart TBX2 BMP10 NRG1 BMP2 MMP2 PMC4095017__F2 Signaling and cross talk of the parathyroid hormone and Wnt signaling pathways in the late osteoblast (osteocyte) WNT3A F2 DKK1 LRP5 LRP6 PTH AXIN2 PMC11663867__F4 Cerebrotendinous xanthomatosis: a literature review and case study CYP7A1 HSD3B7 CYP27A1 PMC9142813__F1 Cellular and molecular basis of thyroid autoimmunity TH TG TSHR TPO PMC4204733__F3 Schematic diagrams of Wingless and Arm structure, and pathway relationships BCL9 APC TEF PMC8691188__F1 Mathematical Model to Characterize the Role of Light Adaptation in Mammalian Circadian Clock RORC SIK1 PER2 PER1 CRY2 CRY1 PMC4518444__F6 Checkpoint clamp and clamp loader in crossover formation ATR RAD51 DMC1 PMC3666388__F5 Adult haemangioblast genetic regulatory network GATA2 FLI1 ETV6 FLT4 ETV2 FLT1 EGFL7 VEGFA ELK3 SOX7 PMC3515549__F7 Screening the Budding Yeast Genome Reveals Unique Factors Affecting K2 Toxin Susceptibility ALG8 VPS41 PMC3250521__F4 Inhibition of isoprenoid biosynthetic pathway by ATST [modified from Holstein et al IPP RHOB RAP1A ARHA PMC4007119__F6 ZZ primary bronchial epithelial cells show an enhanced inflammatory response dependent of the ERK/EGFR/ADAM17 pathway TGFA ADAM17 EGFR AREG PMC7952751__F4 Interplay between autophagy and apoptosis, and the regulation of autophagy and apoptosis by foot-and-mouth disease virus (FMDV) infection TRADD ATG14 ATF4 EIF2A PMC9505762__F1 Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson’s Disease DDT NLRP3 BCL2 IL1B PMC7952751__F3 Schematic representation showing the interaction between foot-and-mouth disease virus (FMDV) viral proteins and host proteins in the innate immune system STAT3 TBK1 MAVS STAT2 IRF9 TANK IRF3 IRF7 TRAF3 SEC62 ESD MX1 TLR7 OAS1 TYK2 PMC7974548__F3 Mechanisms of cardiotoxicityAbnormalities in action potential duration or conduction velocity are associated with a direct block of ionic currents or inhibition of their trafficking from nucleus to cell membrane INA EGFR TNF PMC4868481__F7 Both the EMP (red) and the OPP (blue) pathways share intermediates with the Calvin–Benson cycle (circled in red), but not the ED (green) pathway HEL107 RPE HEL-S-162eP TNLG7C PMC3914444__F2 Scheme of PI3K/PTEN/AKT signaling network activated by heterodimerization of HER2/HER3 receptors induced by heregulin (HRG) and inhibited by pertuzumab, 2C4 HRG PTEN PMC8558833__F9 Anatase and Rutile TiO2 Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway NPS IGF1 CTSK IGF1R PMC329503__F9 The roles of Ras and Mob2 in S MOB2 TPK1 PAG1 RHO ACE2 PMC6460507__F5 Notch and APP signalling pathways ADAM17 APP ADAM10 PMC4362832__F2 Standard pathway by which microRNAs are processed and loaded onto RISC to regulate gene expression TF DGCR8 DROSHA PMC4362832__F1 Endocrine resistance in breast cancer cells EGFR FGFR1 PMC8700759__F5 C4d Deposition after Allogeneic Renal Transplantation in Rats Is Involved in Initial Apoptotic Cell Clearance CD40 IFNG CD80 APC PMC2814179__F1 Therapeutic targeting of NOTCH1 signaling in T-ALL MAML1 ADAM10 NOTCH1 PMC4300045__F3 Gene ontology (GO) analysis using the DAVID software RFWD2 BAX CASP9 ATR PERP PTEN MYC TSC2 CASP3 FES CDK2 ATM MDM2 PMC8700759__F6 C4d Deposition after Allogeneic Renal Transplantation in Rats Is Involved in Initial Apoptotic Cell Clearance HTRA2 BAX CASP4 MCL1 ROCK1 GAS2 TNF APAF1 DIABLO PMC9263262__F1 MicroRNA/lncRNA Intertwined With the Wnt/Beta-Catenin Axis in Regulating the Pathogenesis of Triple-Negative Breast Cancer APC GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC4216940__F2 Majority of mitochondrial proteins/enzymes undergo reversible lysine acetylation ECHS1 ETFDH FH UQCRB HEL-S-5 ACADVL CS PMC9520263__F3 Tumor resistance to immune checkpoint blockade and combination strategies to overcome resistance STAT3 TLR3 TLR4 TLR8 TLR7 PMC5989870__F1 Schematic diagram MMP7 SOX9 APC GSK3B OSR1 CCND1 CTNNB1 PMC6449344__F1 CpgA is pivotal in prevention of 4PE-mediated metabolic gridlock HEL107 RPE NAGA HPR PMC6049507__F7 MiRNA and host targets are involved in common pathways CCND2 CDKN1B MAP2K1 NFYC RAC1 PMC7578260__F2 TRIM-mediated regulation of the TLR signaling pathway TRIM13 TRIM38 TRIM56 MAL TAB3 IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 PIN1 IRAK4 TRIM21 MYD88 TRIM62 TRIM28 TLR3 TRIM9 TLR4 TRIM8 TRIM6 TRIM29 TRIM23 PMC8101438__F2 MTOR signaling pathway and its role in metabolic programs and differentiation of T-cell subsets BAD FAS CAD SOCS5 TFEB CCR7 SMAD4 STAT4 SOCS3 PMC3675586__F1 Sugar nucleotide biosynthetic pathways identified in the genome of P GAL MPG PMC4324580__F5 Proposed mechanism of action of glycyrrhetinic acid (GA)-induced G1-phase arrest in non-small cell lung cancer (NSCLC) cells CDK6 PCNA DHFR CDK2 EIF2A SUV39H1 CDK4 PMC8997602__F1 Impact of Lipid Metabolism on Antitumor Immune Response STAT3 STAT1 SLC27A2 IL8RB PMC6341304__F1 Mitochondrial dysfunction and diabetic retinopathy TFAM POLG PMC7704563__F8 Schematic overview of the distinct roles of p38A depending on the disease stages during NAFLD progression NR1C1 CXCL1 CASP3 BCL2 PMC8097353__F1 Deubiquitinating enzyme USP42 stabilizes RNF43/ZNRF3 at the plasma membrane USP42 RNF43 ZNRF3 GPR49 LGR6 PMC2752535__F4 Common features of host-Flaviviridae interactions ZAP70 STAT3 SKIL ADAMTS4 RAF1 SMAD2 MLXIPL WDR37 FLT4 RBPMS CSNK2A1 CYBA TBL3 STIM2 DNAJB1 TCOF1 HEL161 AP3S2 USP11 ZNF467 DUSP11 YAP1 KCNK3 BCAP31 GSC SMURF2 TBK1 HEL-S-76p MYO3A NCOA6 PRPF40A MAP3K14 TRRAP TRIM62 YEATS4 RIPK2 TEAD3 HSF1 CHUK TNPO2 CDH10 CITED2 ZNF148 SMAD6 TFAP2A PPP2R1A RAC1 MT2A SMURF1 NUAK1 ELAVL1 BCAT1 FOXA2 CISH UBE2I PMC7945298__F9 NcRNAs involved the PI3K-Akt signaling pathway RHEB RPTOR MLST8 TSC2 COL1A1 TSC1 CDKN1A MTOR VEGFA COL5A2 EIF4E PMC6049507__F6 MiRNA targets in cancer pathways CREBBP MDM2 PMC7945298__F8 Subnetwork of PVT1 and HOTAIR SKIL PTP4A1 HIF1A FJX1 ABCA1 DUSP2 HMGB3 KPNA2 RB1 FRMD6 NUFIP2 MPDU1 GDF11 MIDN KIAA0513 F3 MMP2 TFAP2C TBC1D2 TNFRSF21 CCND1 SOX4 CHAF1A STK17B LIMK1 RRM2 CAPN15 PTGFRN CTSA VEGFA SLC22A23 CERCAM RAP2C ZMAT3 CDKN1A GNS PLXNA1 ANKH DIPLA1 NRIP3 CEP55 TRIM29 JARID2 PMC3674463__F1 EGFR pathway and downstream signaling pathways, including KRAS EGFR BRAF PTEN KRAS PMC3626681__F1 Molecular and biochemical studies in hyperlysinemia patients GCDH ECHS1 ALDH7A1 PIPOX AADAT AASS PMC8290102__F1 Streptococcus pneumoniae, S. pyogenes and S. agalactiae membrane phospholipid remodelling in response to human serum SPN PGP C1S PC PMC6923788__F1 Signaling by the phosphatidylinositol-3-kinase (PI3K)-AKT- mammalian target of rapamycin (mTOR) pathway TSC2 FGFR1 PMC11510507__F5 Signaling pathway diagram of phagosome (the images are sourced from the DAVID database 2024 HEL-S-99n RILP ST7 CD36 TLR4 VAMP3 STX18 CD14 MARCO TUBB MPO PMC6429784__F4 Schematic diagram for anti-ethanol caused damage in K PGC ERG PMC4278533__F4 Gene set variation analysis of the antigen processing and presentation pathway (APP) and the natural killer (NK) cell gene set TAPBP CANX CMKLR1 ASCL2 CLIC3 SET PDZD4 HEL-S-99n IFNG NCAM1 IL2RB PRF1 MHC2TA CX3CR1 CHST12 GNLY PMC7913835__F3 Protein–protein interaction network between gene products with high-impact variants contained in the top enriched pathways and those presenting differentially methylated sites in CLZ-treated patients SLC12A5 DLGAP2 KCNN3 AKT3 RXRG GABRA4 GABRG3 GABRR3 PRKCB GNAS RYR3 PLCG1 KCNJ3 CACNA1I ADCY9 PRKCA KCNMA1 NR1A2 GRIA4 RYR2 LRP8 HEL-S-7a PCLO KCNJ6 ITGB3 GABRA6 MED24 RXRA ABCC8 APOB KCNN2 TBC1D4 PRKG1 PMC12021615__F4 Other E3s and DUBs in NAFLD ACLY TRIM56 FASN ACSS3 SKP2 ACAT1 PDHA1 USP36 USP15 NLRP3 FOXO1 HSF1 MDM2 PMC12021615__F3 E3s and DUBs in NAFLD-related ERS, mitochondrial malfunction, and lipid autophagy USP14 TG HMGB1 NR2A1 CYP2E1 TXNIP FASN RNF186 EIF2A TRIB3 PMC3855612__F4 Human myometrium differentially expresses mTOR signalling components before and during pregnancy: evidence for regulation by progesterone RHEB TSC2 RICTOR TSC1 PTEN MTOR DEPTOR IRS1 PMC12021615__F2 E3s and DUBs in SIRT, TGFB, JAK, TLR4 and STING signaling pathway in NAFLD RNF13 CARM1 TLR4 USP22 SMAD4 TRIM2 ARID2 SIRT1 PMC12021615__F1 E3s and DUBs in TAK1, ASK1 and mTOR signaling pathway in NAFLD RHBDF2 TRIM31 DDX5 MTOR TRAF3 TRAF6 DEPTOR TSC2 RICTOR TSC1 NLRP3 USP4 USP18 MUL1 MAP3K7 MAP3K5 CYLD PMC5244594__F12 Working model of how the glucose dual-affinity transport system functions in glucose transport, signaling, and CCR CIRSR PMC5324334__F7 TSPC induces cell cycle G1 arrest probably mediated by CDKN1A and CDKN1B CKIs in a TP53-independent manner, while CDDP induces S and G2/M arrest via TP53/CDKN1A pathway in SK-MEL-5, and preventing dephosphorylation of CDK1 in both cell lines CDC2 CCNE2 CDKN1A CDK2 PMC7309952__F6 Regulatory network of the BCL2 family in gynaecologic and breast cancer POR BAX PIK3CA BCL2L1 MYC BIK PMC8622331__F4 Bacterial Ghosts-Based Vaccine and Drug Delivery Systems NLRC4 TLR1 TIRAP TLR4 CD14 TLR5 LPP TNF LBP PMC7343851__F7 SSP regulation of PI3K/Akt signaling pathway RHEB RICTOR ELL PMC4823950__F1 NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells CASP9 NGF MCL1 CASP3 FADD PMC8747764__F7 TPMT mRNA Expression: A Novel Prognostic Biomarker for Patients with Colon Cancer by Bioinformatics Analysis COMP FAS HSPG2 UQCR10 THBS2 NDUFV2 THBS3 NDUFA6 GFPT1 IGF1R ETHE1 CALML4 HEL20 PSEN1 LAMC1 NDUFAB1 FLNA NDUFS3 MCEE GNPNAT1 VEGFB MLX ITGA6 HEL-S-32 TLN1 MYL12B NDUFC1 HEL-S-26 ACTN1 FH FPGT HK2 GMDS ME1 NANS SDHD CYB5R4 DLAT ECHDC1 PAPSS2 COX7A2 PGM3 ME2 SUCLG2 CASP3 NDUFS1 PMC6323238__F1 Regulatory system of ERK1/2 signaling DUSP5 KSR2 EGFR KSR1 DUSP9 DUSP4 SHE MYC DUSP2 FOS DUSP7 PMC8322647__F1 Contemporary View of Natriuretic Peptides in the SARS-CoV-2 Era NPS ACE2 RAC1 PMC4498564__F1 Heme biosynthetic pathway AIP CPO FECH UROS PMC4649622__F4 Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice SOCS1 BAX RARA PSMB8 IRF9 PIAS1 IRF1 MX1 IFI35 JAK1 TYK2 PMC12248764__F5 Fatty acid synthesis pathway in L HES2 HEL-S-5 PMC4649622__F5 Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice HTRA2 TBK1 FAS TRADD LIMK1 CYCS ACIN1 GAS2 NAIP ZC3HAV1 ARHGDIB BIRC2 TRAF2 DIABLO LMNA FADD SPTAN1 PMC4343025__F1 Genome organization and biogenesis of microRNAs (miRNAs) AGO4 RAN DGCR8 AGO1 AGO2 DROSHA PMC5000672__F6 Proposed signal pathway activated by HMDB in HeLa cervical cancer cells CDK6 CDK2 MTOR CDK4 PMC8997602__F4 Impact of Lipid Metabolism on Antitumor Immune Response COX2 LAG3 PMC7500051__F5 Opposite immune effects of M1-like and M2-like TAMs in the tumor microenvironment IFNG TH IL10 CCL22 ARG1 CCL5 FOXP3 CEBPB CCL20 PMC10243463__F1 BMP4 signaling in trophoblast emergence from pluripotency TGFBR2 BMPR2 ACVR2B ACVR2A MAP3K7IP1 BMPR1A BMP4 ACVR1C PMC5702246__F6 The PTHLH/PTH1R-ATF2 negative-feedback loop PTHLH ATF2 UNK PMC3364790__F4 Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells EHF TAL2 HEL-S-78p TNLG7C CP PMC11046856__F4 Crosstalk between Wnt/Beta-catenin, Notch, and TGFB signaling pathways during wound healing COL1A1 VEGFA HES1 AXIN2 PMC9179857__F3 Loss of CHGA Protein as a Potential Biomarker for Colon Cancer Diagnosis: A Study on Biomarker Discovery by Machine Learning and Confirmation by Immunohistochemistry in Colorectal Cancer Tissue Microarrays PTPRO STOM SPARC PMC11046856__F2 Non-canonical Wnt signaling pathways JUN ROR2 RAC1 PMC11046856__F1 Canonical Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 CTNNB1 PMC7017008__F2 Main molecular mechanisms underlying EMT activation STAT3 EGF HGF SMAD2 RHO TWIST1 PMC6476857__F12 Graphical abstract shows the protective mechanism of SFN against Ar-induced damage in the kidney tissue via PI3K/Akt-mediated Nrf2 signaling pathway KEAP1 SFN PMC6277854__F2 Major signaling pathways and therapeutic targets in CLL cells BAX SYK JUN BAD MCL1 ATF2 MMP9 RHO MYC CTNNB1 BTK BCR CXCR4 LEF1 PMC8580341__F4 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors KLF4 STAT3 RAF1 PIM1 BCL2 TYK2 PMC8580341__F3 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors HOXB7 PTEN MDM2 GRB2 SHE NPRC PMC8580341__F2 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors CTCF RNF43 APC GSK3B AXIN1 ZNRF3 EZH2 NLK CTNNB1 PMC8529754__F2 An update on extra-oral bitter taste receptors TRPM5 PLCB2 CALHM3 CALHM1 PMC5777140__F5 Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer’s disease CD44 VWF CD36 NPNT CHAD CD47 PMC8580341__F6 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors RHEB BAX TSC2 BAD TSC1 SOX2 PTEN MDM2 PMC7559526__F8 Melanin synthesis pathway related genes in dorsal and ventral skin of LBM ducks ASIP POMC PMC7565286__F1 Summary diagram of transport, signaling and degradation of vitamin A metabolism and RA synthesis ALDH1A3 HEL-S-53e RBP4 ALDH1A2 DHRS3 PMC8580341__F5 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors BAX SIRT1 PMC9343736__F3 Endothelial cells in vascular calcification BMP6 MGP SMAD2 BMP4 SOX2 BMP2 IL18 SMAD4 BMP7 RUNX2 PMC7039698__F1 Topical cholesterol/lovastatin for the treatment of porokeratosis: a pathogenesis-directed therapy GGPS1 HMGCS1 IDI2 ACAT1 HMGCR ACAT2 PMVK MVD FDPS IDI1 MVK PMC5951830__F7 Metabolism of bicarbonate and t6A37 formation in cytoplasm and mitochondria YRDC OSGEPL1 CA9 PMC5882218__F1 Models of the Hippo pathway in mammals LATS1 LATS2 PMC6037882__F4 Role of mucins in CSCs MUC1 MUC4 PMC5325457__F5 Ubc13: the Lys63 ubiquitin chain building machine CD40 TRADD TAB3 RNF8 IRAK1 TRAF3 TRAF6 TRAF2 IRAK4 FADD PMC11853667__F1 mTOR signaling pathway in cells RHEB MLST8 TSC2 RICTOR TSC1 WNT3A ULK1 PTEN MTOR PMC7013532__F1 Pathway associated with terpene synthesis in Camellia sinensis IPP FAS MVK PMC9416350__F2 Peptide-Based Vaccines in Clinical Phases and New Potential Therapeutic Targets as a New Approach for Breast Cancer: A Review CXCL9 CXCL11 CD80 CCL3 CCL4 CXCL10 PMC7048048__F2 Directionality of transketolase 2 (TKT2) impacts the in silico essentiality of two genes encoding EDD and EDA from the Entner–Doudoroff pathway RPE TNLG7C PMC7048048__F1 Core networks generated by the redGEM algorithm from iJN1411 genome-scale model RPE ME2 NADK MAL PC CS TNLG7C PMC7229984__F1 Retrospective clinical trial experimentally validates glioblastoma genome-wide pattern of DNA copy-number alterations predictor of survival FRS2 EGFR AKT3 TLK2 KDM5A PTEN MDM4 PSENEN CSNK1E NBPF14 CCNE1 SUFU PTCH1 SHH SMO MDM2 DLL3 GLI3 CDK4 PMC9224267__F2 EGFR-Mutated Non-Small Cell Lung Cancer and Resistance to Immunotherapy: Role of the Tumor Microenvironment STAT3 EGFR PMC6248540__F2 Pathway analysis infers molecular pathway of relapse CD44 TG ASAP1 RHO PMC2975936__F1 Classical pathway of complement activation by antibody HEL-S-62p C4A C4B_2 PMC8192181__F5 Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NFKB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways STAT3 CCL3 IL16 CCL5 CXCL10 TNF PMC8063837__F2 Models of signaling in Hedgehog pathway activation in cancer SMO IL1A IL1B PMC7401422__F3 Visualization of the cell cycle pathway from WikiPathways POLE2 PCNA POLE PMC6209826__F10 We observed that chlorogenic acid showed binding affinity to interact with ctDNA, VEGF and VEGF receptors VEGFC PIK3CA JUN MMP14 TIMP3 TGFBI TGFB1 TIMP1 TIMP4 EGFR PIK3CD MMP9 MTOR VEGFA FOS FGF2 FOXO1 FOXO3A IL18 MMP2 MMP3 MDM2 KDR PMC8063837__F1 Hedgehog signaling pathway and its possible inhibitions GPR161 BOC SUFU SMO PMC4621741__F1 Mutant SPOP promotes genomic rearrangements within chromosomes SPOP MAP3K7 PMC10302997__F1 Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention ATG10 ATG3 ATG16L1 ATG12 ULK1 PI3 UVRAG MTOR ATG5 PMC5732091__F6 CHOLANGIOCYTE PRIMARY CILIUM IN HEALTH AND DISEASE APC GSK3B ARHA UNK CTNNB1 PMC3924769__F6 DAF-12, a nuclear hormone receptor regulating development and lifespan HSD3B7 CYP27A1 ADA PMC3961794__F1 Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1 STAT3 TLR4 IRF3 JAK1 TYK2 MYD88 PMC3294814__F1 Proposed biosynthetic pathway of RQ (compound 1) TH COQ7 COQ3 COQ2 COQ6 COQ5 PMC4849794__F7 Rotenone Susceptibility Phenotype in Olfactory Derived Patient Cells as a Model of Idiopathic Parkinson’s Disease STAT1 JUN E2F4 tmp_locus_29 TAF6 PMC6025799__F2 Roles of IGF2BP1 in promoting and suppressing tumor growth and invasion via regulating different mRNA targets, under the modulation of upstream non-coding RNAs MAPK4 CD44 MKI67 IGF2BP1 C2 RGS4 PTEN PTGS2 RAC1 PS1TP5BP1 PMC3063194__F1 Elicitation of innate immune response in EBV infection TBK1 TLR3 TLR9 TANK IRF3 IRF7 TLR7 IL6 TRAF3 MYD88 PMC4694849__F4 PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines RHEB PIK3CA TSC1 PIK3CD PTEN MTOR PRKCB PMC10299455__F2 NOTCH signaling pathway, ligands, and inhibitors BLK FYN LYN MYC HES1 RBPJ PMC3127069__F1 The mTOR-signalling pathway from growth factor receptor through mTOR RHEB PTEN MTOR PMC8869290__F1 Oligomannose-Type Glycan Processing in the Endoplasmic Reticulum and Its Importance in Misfolding Diseases UGGT1 EDEM3 EDEM1 EDEM2 PMC3281277__F1 Proteolytic processing of the BACE1 substrates APP and NRG1 EGF NRG1 BACE1 ADAM10 PMC5882331__F2 Therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer BAX ATR ATM TIGAR SCO2 MDM2 XPC PMC3063194__F2 Evasion of immune responses by individual EBV products CXCL11 IL10 FAS IRF9 CASP3 IRF3 IRF7 TLR7 IRF4 FADD PMC6326993__F2 Schematic overview on a striatal medium spiny neuron synapse TH GNAO1 PDE10A GNAL PMC8259786__F4 NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease SOX9 MGP BMP2 PMC8259786__F3 NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease HBEGF BMP2 WNT4 NOTCH1 CTNNB1 PMC8259786__F2 NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease EFNB2 CDKN1A DLL4 DLL3 RBPJ PMC8869508__F3 Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches NLRC4 NLRX1 MAVS NLRP3 COX2 IL1B PMC3706396__F6 S100A8/A9 (Calprotectin) Negatively Regulates G2/M Cell Cycle Progression and Growth of Squamous Cell Carcinoma S100A8 CDK2 CCNB1 S100A9 PMC6587703__F2 Mechanistic interactions between VEGF-targeted anti-angiogenic therapy and checkpoint inhibitors in the systemic treatment of mRCC CDC42 GAL TGFA PTEN GRB2 CCND1 VHL PMC4865041__F7 Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database CDKN2A BCL2L1 PACRG MCL1 BNIP3 BCL2 CCND1 SET PARP1 PMC6336016__F2 Application of built-in adjuvants for epitope-based vaccines TLR1 TLR3 TLR4 MAL TLR9 TLR5 IRF3 TLR7 MYD88 PMC7568023__F2 Engineered nanomaterials as fighters against SARS-CoV-2: The way to control and treat pandemics NPS C4B_2 ACE2 PMC4159649__F6 Identified glycotransferases involved in O-glycosylation and associated biosynthetic pathway GAL HEL-S-62p FUT6 FUT3 FUT5 B4GALNT2 B3GNT3 SIAT4C CHST5 GAL3ST2 B3GNT6 GCNT3 B3GALT5 B4GALT4 PMC3697962__F2 Insulin-like signaling pathway INSR PTEN PMC8666273__F5 Runx3 regulates iron metabolism via modulation of BMP signalling BMP6 HAMP RUNX3 PMC8036928__F3 Antioxidant metabolism in circulating tumour cells (CTC) MAL ME1 CPT1A PMC9483553__F2 Prominent Role of miR-942 in Carcinogenesis of Tumors DLG2 SALL1 GDNF ALX4 APC GSK3B BATF2 SOCS3 PAX6 GFI1 BAMBI MBL2 SFRP4 ZNF471 CUL4B RRM2B FOXA2 GAS1 PMC11797775__F2 The main cell signalling pathway mechanisms reportedly disrupted by hyperglycaemia-associated oxidative stress and AGEs in MSCs, osteoblasts and osteocytes, potentially contributing to impaired bone healing in T2DM patients APC MTOR RUNX2 PMC4664460__F3 Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain TSC2 TSC1 EIF4E PMC8656569__F1 miRNAs in the Regulation of Cancer Immune Response: Effect of miRNAs on Cancer Immunotherapy TRADD TIRAP IRAK1 TRAF6 CYLD TRAF2 IRAK4 FADD MYD88 PMC9327201__F4 Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment GLS CSF3 PMC3351343__F6 Working model for onset of emphysema in Fut8+/− mice upon exposure to CS TF FUT8 SMAD2 PMC3734825__F7 Upregulation of HSP70 and the phosphorylation of STAT1 induced by bortezomib (BTZ) decrease the cytotoxic activity against ovarian cancer cells STAT1 BAD HSF1 PMC5932138__F6A Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition FH HEL-S-62p C4B_2 CLK1 PMC8502867__F2 Safe Path at the Fork: Ensuring Replication-Associated DNA Double-Strand Breaks are Repaired by Homologous Recombination RAD51 EEPD1 EME2 PRIM1 PRIMPOL SSB PMC8960495__F9 In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice RHOU AURKA SETD4 KRAS CP PMC2475726__F10 F igure 10.— RAD52 REV1 PMC8960495__F7 In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice DIXDC1 RHOU DKK3 CP PMC11016009__F4 B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention STAT3 ULBP2 PMC5913290__F1 Key elements in the DNA damage response (DDR) pathway ATR ATM SSB PMC4246027__F1 NEUROTROPHINS IN THE VENTRAL TEGMENTAL AREA: ROLE IN SOCIAL STRESS, MOOD DISORDERS AND DRUG ABUSE TRAF4 NGF GRB2 BDNF TRAF6 PMC8387624__F5 Functions of Hepatitis B Virus Encoding Proteins: Viral Persistence and Liver Pathogenesis STAT3 CDK2 EZH2 APOBEC3B CTNNB1 PMC8387624__F4 Functions of Hepatitis B Virus Encoding Proteins: Viral Persistence and Liver Pathogenesis VDAC3 STAT3 EGR1 ATF5 SP1 P4HA2 EZH2 MMP9 MTOR CTNNB1 FOXO1 ZHX2 MMP2 PMC8574196__F3 ApoE and AB interaction TREM2 APOE LDLR ABCA1 PMC6518354__F1 Schematic drawing presents the detail signaling pathways of endometrial carcinogenesis EGF BAD APC PTEN MTOR SRC CTNNB1 PMC7127985__F1 Molecular pathways involved in PKD, autophagy and apoptosis PRR5 BAX BAD ATG3 ATG12 ULK1 MTOR PMC8194326__F1 T follicular helper cells: linking cancer immunotherapy and immune-related adverse events CD40 CD80 PMC6130072__F2 Transcription factor interactions in endothelial cell functions RHEB TSC2 TSC1 FOXC2 FOXO1 ETV2 RHO PMC9338502__F3 Bioinformatics analysis and experimental verification of Notch signalling pathway-related miRNA–mRNA subnetwork in extracellular vesicles during Echinococcus granulosus encystation NUMB HES1 HES5 PMC7793262__F2 Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation IFNG STAT3 STAT1 IL10 PMC4963951__F2 The roles of monocytes and polarized macrophages in HTS formation STAT3 NOS2 ARG1 CXCR4 PMC2818240__F5 Oxidative stress and glutathione in TGF-Beta-mediated fibrogenesis SP1 SMAD2 SMAD4 PMC3414727__F2 AKT/mTOR signaling and crosstalk with glycolysis and mitochondrial oxidative phosphorylation TSC2 TSC1 HIF1A PMC9556184__F1 Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson's Disease VDAC3 BAX PINK1 PMC408363__F1 Complexity of the CD28/CD152–B7-1/B7-2 T-cell costimulatory pathway APC CTLA4 PMC3414727__F1 AKT/mTOR signaling pathway BAD ULK1 GSK3B PTEN MTOR DEPTOR EIF4E RHEB MLST8 TSC2 RICTOR TSC1 IGF1 SESN3 PMC8510628__F1 Formyl Peptide Receptors in Neurological Diseases via Regulating Inflammation ANXA1 SRC IL1B PMC2949778__F1 Folate metabolic pathway RFC1 MTRR TYMS MTR PMC5359927__F1 Main signaling pathways involved in vasculogenic mimicry MMP14 EPHA2 ALK COX2 CRIPTO MMP2 BNIP3 NODAL TWIST1 PMC6990917__F8 Mechanism of the protective effect of fenofibrate against diabetic nephropathy NR1C1 FYN FGF21 NQO1 GSK3B PMC3536591__F2 Ingenuity pathway analysis (IPA) top network that incorporates 9 genes identified as differentially methylated between methotrexate-naïve cases and controls by HM27 analysis BDKRB1 S100A7 IGF2BP1 LAMA1 COX1 PRKRA HCRTR1 MYC TIAL1 MPL CCNE2 LIN54 TARBP2 NPY EIF2A EIF2AK2 MYBL1 PMC7758122__F4 Cross-talks between seven primary regulatory pathways of RDNI for inflammation RYR2 IL16 PTGS2 PMC7709275__F1 Role of the unfolded protein response (UPR) in cancer ATF4 EIF2A PMC5893845__F6 Schematic diagram on the transcriptomic profiles of metabolic pathway genes involved in the enhanced MCFA production of mutant cC14TE_B3 D CIRSR HEL-S-5 PDC GIP PMC7709275__F3 MiRNAs regulate tumor characteristics including apoptosis, invasion, EMT, and metastasis by regulating the UPR LAMP3 HMGB1 JUN TUSC3 SNAI1 GDF15 ATF4 EIF2A PMC8222490__F2 Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue TNC COMP HSPG2 ITGB4 CD36 FREM1 DMP1 HMMR FRAS1 VTN IBSP GP5 CHAD ITGAV GP1BB ITGB6 GP1BA GP6 AGRN COL1A1 ITGA2 ITGA6 VWF GP9 DAG1 ITGA7 ITGA4 ITGB7 NPNT SDC1 ITGB3 ITGA2B RELN CD47 SPP1 CD44 ITGB1 ITGA1 ITGB5 SV2C PMC7709275__F5 LncRNAs regulate the tumor characteristics apoptosis (a), invasion and metastasis (b), and metabolism (c) by regulating the UPR HEL-S-84 ATF4 EIF2A EGLN2 PMC6735501__F1 Initiating events in autophagy ATG101 ATG10 ATG3 ATG16L1 PIK3R4 ATG12 ULK1 RB1CC1 SQSTM1 ATG5 PMC3440368__F7 Disturbed Relaxin Signaling Pathway and Testicular Dysfunction in Mouse Offspring upon Maternal Exposure to Simazine NOS2 MMP9 PMC10538757__F2 STRING analysis of protein–protein interactions AQR STAT3 ABAT PRPF19 BAD RBM22 USP2 MAL SYF2 REL NOTCH1 ABCB1 PMC8355346__F1 Molecular mechanisms and signaling pathways of ferroptosis interact with AS SLC3A2 ATF3 GPX4 TLR4 HAMP SLC7A11 PMC5748821__F1 Nuclear factor-E2-related factor 2 (NRF2) pathway with a focus on skin barrier function and environmental stress protection RAD51 SLPI KEAP1 GCLM SLC7A11 SQSTM1 ME1 TP53BP1 OGG1 TXN RBX1 CDKN1A COX2 EPGN NQO1 GCLC BCL2 SRXN1 HEL-S-26 ATG5 PMC5587385__F7 InterferonA Negatively Regulates the Expression of Endothelial Nitric Oxide Synthase and Nitric Oxide Production: Implications for SLE VCAM1 IRS1 PMC6601327__F6 Proposed model of OLFM4‐induced STAT3 activation mediated by the LGR5‐Wnt signaling pathway in HCC STAT3 OLFM4 APC GPR49 PMC11120359__F1 Representation of the signaling pathway in the activation of CXCR4 (left) and ACKR3 (right) CXCL12 ACKR3 MTOR CXCR4 PMC7426575__F5 Schematic Model for Major Immune Escape-Initiating Domains and Immune Escape Points in Tumor-T Cell Interaction(A) Major immune escape points depicted in schematic model, highlighting tumor-T cell interaction at last stage of cancer-immunity cycle CXCL9 IFNG CXCR3 PMC5789323__F2 Simplified relationship between ROS-induced redox signaling and mitochondrial dynamics OPA1 KEAP1 HIF1A PMC7859329__F2 Thyroid hormones, Wnt pathway, and miRNAs crosstalk DKK4 MED13 CTNNB1 PMC10218387__F3 Major pathways of carbon and energy metabolism in M382 AGXT2 HEL107 MIA HEL-S-304 HEL-S-32 SMO TNLG7C PMC3733085__F2 Simplified scheme of the pathways of complement activation FH HEL-S-62p C1S C1R CD46 CD55 PMC2844310__F3 Relationship of NFKB to genes identified as “linearly” changing with age on the basis of cocitation analysis (Genomatix BibliosphereTM) is shown as a Bibliosphere image RAMP2 ECD tmp_locus_29 NFKB1 NPHS1 PMC5966807__F4 A schematic showing the proposed signaling pathways in type II cells activated by neurochemicals at the carotid body sensory synapse PANX1 H1-2 PMC2680180__F1 Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins? SIRT3 SIRT4 SIRT5 PMC9318003__F2 Will We Unlock the Benefit of Metformin for Patients with Lung Cancer? Lessons from Current Evidence and New Hypotheses RHEB EGF TSC2 TSC1 ERBB2 HIF1A MTOR SIRT1 PMC5693226__F1 Rationale for mTOR inhibitor + NOTCH inhibitor combination DLL4 PTEN RIDA MTOR HES1 PMC8168945__F1 Cholesterol Contributes to Male Sex Differentiation Through Its Developmental Role in Androgen Synthesis and Hedgehog Signaling CYP51A1 EBP SC5D DHCR24 DHCR7 HSD17B7 PMC5457688__F4 Précis of signaling pathways involved in glioma and inhibition by mTOR, AKT, PI3K and ERK inhibitors and genetic configuration of TSC1 and TSC2 RHEB TSC2 TSC1 PTEN MTOR EIF4E PMC8168945__F6 Cholesterol Contributes to Male Sex Differentiation Through Its Developmental Role in Androgen Synthesis and Hedgehog Signaling DHH SHH IHH PMC11307883__F3 Metabolic pathways of the microRNAs and their target genes MAX CAD GAD1 CDKN2B IL6 SKP2 CSF3R RB1 ABAT GLUD1 CDKN2A HEL-S-8a CDK6 ALDH5A1 PIG59 CCNE1 CDK2 SKP1 GLS2 CCND1 CDK4 PMC6562905__F2 Role for fibroblast-derived metabolites in tumor-stroma interactions PIG59 LDHB AEN PMC9585453__F4 Systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury APC GSK3B LRP5 LRP6 CTNNB1 PMC9496700__F1 Emerging Roles of miRNA, lncRNA, circRNA, and Their Cross-Talk in Pituitary Adenoma TESC IFITM1 RRBP1 MTOR CCNB1 TUG1 EPHA7 IRAK4 EIF4E PMC6431727__F5 RANKL-RANK signaling pathway via Btk in osteoclast differentiationTec family kinases are activated by RANK and bind to scaffolding proteins (BLNK or SLP76) activated by ITAM signaling, thereby forming a complex that cooperates to activate PLCG2 TEC SYK BTK PLCG2 BLNK NFATC1 PMC2440410__F3 Regulation of post-cushion valve maturation to thin fibrous leaflets also includes EGF receptor signalling in addition to differential signalling of the pathways in c EGF SMAD1 DKFZp781O1323 ERBB4 EGFR SMAD2 SMAD6 SMAD4 ERBB3 HBEGF BMP4 BMP2 ERBB2 PMC10671144__F7 Network analysis of oxaliplatin revealed that oxaliplatin as a master regulator was predicted to be inhibited and the SPINK1 pancreatic cancer pathway was inactivated in ischemic cardiomyopathy TGFBR2 TGFB1 SPINK1 TMPRSS15 RGS11 SQSTM1 PRSS2 PRSS1 CLPS F2RL1 CP TGFBR1 PMC10671144__F1 Carboplatin molecular network in cancer JUN SMAD2 EZH2 RUNX2 TBX21 PDX1 tal-1 CDKN1A BRCA1 NFKB1 CDKN1B RELA TP63 EP300 PMC10671144__F3 Upstream regulator analysis of cisplatin revealed the upregulation in FAS, PRKCA, and CDKN1A, and involvement of tumor microenvironment pathway (lung adenocarcinoma (LUAD) [lung] cisplatin 9800) RPS27 ATF3 PPM1D BTG2 GADD45A XPC CP PMC4889031__F1 Deletion of ERA in uterine epithelial cells leads to infertility, however, this receptor loss does not prevent estrogen induced epithelial cell proliferation () STAT3 EGF IGF1 EGFR LIF BMP2 MUC1 HEL110 IGF1R PMC4821530__F5 GUIdock: Using Docker Containers with a Common Graphics User Interface to Address the Reproducibility of Research PIK3CA ZRSR2 MCL1 CRKL BRAF EZH2 CDKN2B KRAS XBP1 WWP1 BCL2L1 SF3A1 SPOP CCNE1 NF1 KDM5C CCND1 PMC8535854__F1 Metabolic reprogramming orchestrates primary tumor cell invasion and supports PMN priming via exosomes ATG3 PMC5900707__F1 Schematic diagram of RIPK1 domains, interacting proteins, post-translational modifications, and the catalytic enzymes that read or write these modifications RIPK3 TRADD RIPK1 OPTN CYLD PELI1 TRAF2 PMC8535854__F2 Metabolic changes allow cancer cells to survive in circulation and promote colonization of distant organs SRC PRODH HEL-S-26 PMC6096407__F5 Several lncRNAs work at the post-transcriptional level as competing endogenous RNAs for microRNAs, titrating microRNA effector complexes away from their mRNA targets (e.g SIRT1 PMC6096407__F4 LncRNAs can regulate gene expression by participating in chromatin looping (e.g TCF4 ASCL2 CTNNB1 PMC6096407__F1 Several lncRNAs interact with transcription factors recruiting them to their target genes (e.g TCF4 CTNNB1 PMC8843871__F3 Paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine EIF4B CUL4A NOP2 ANXA2 PPP2R2A CTNNB1 PMC6627906__F1 Signaling pathways and receptors involved in uveal melanoma (UM) and cutaneous melanoma (CM) CXCL12 HGF IGF1 GNA11 BRAF PTEN IGF1R MTOR CXCR4 PMC6096407__F3 LncRNAs activate (e.g HDAC1 PHB2 DKK1 CTNNB1 PMC6096407__F2 Several lncRNAs bind to specific combinations of regulatory proteins, potentially acting as scaffold elements within ribonucleoprotein complexes, stabilizing their targets (e.g CDK6 GSK3B TCF4 HNRNPK AXIN2 CTNNB1 PMC2746247__F1 Pathway Engineered Enzymatic de novo Purine Nucleotide Synthesis PURB NDP PMC5900707__F2 Activation of TNFR1 may promote multiple alternative signaling pathways, including the activation of NFKB, RIPK1-independent apoptosis (RIA), RDA, and necroptosis RIPK3 TRADD TAB3 TRAF5 RIPK1 TNF CYLD PELI1 TRAF2 FADD PMC10519225__F5 Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles B2M PROC PMC6862675__F4 IPA® analysis of signalling pathways of the genes differentially expressed upon lysozyme treatment UBC HEL113 FYN IFI6 ADM PLAUR LRIF1 IL36A RGS1 GDF1 KHDRBS1 PMC6518697__F6 Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease STAT3 TNC KLF2 SPINK1 HEY2 TLL1 SCUBE3 SOCS3 FHOD3 EFNA2 ANGPT1 DNA2 BCAN SAA2 LFNG NPRC MMP7 AIP NTRK2 EZH2 LGALS9 VEGFA PDGFRA DNAH2 DENND2A CP EMCN PMC7026191__F3 CEACAM3 signaling connections BCL10 CEACAM3 SRC CARD9 PMC11302569__F3 Four key mechanisms of gut microbiome associated with the occurrence and progression of colorectal cancer a HGF CCR6 APP PMC6252326__F1 Schematic representation of the tryptophan metabolism pathway HEL-S-90n KYNU KMO PMC4935337__F6 Proposed model for the action of KP-A021 on the RANK signaling pathways in osteoclast differentiation, bone resorption, and cytoskeletal rearrangement MAP3K7IP1 NFATC1 SRC TRAF6 TRAF2 PMC2606944__F9 Role of Small GTPases and AvB5 Integrin in Pseudomonas aeruginosa–Induced Increase in Lung Endothelial Permeability ARHA CTNNB1 PMC7876385__F3 Major mechanisms of drug resistance in BCSCs STAT3 APC PTCH1 GSK3B LRP6 PTEN MTOR ABCG2 CTNNB1 PMC7876385__F4 Novel strategies of drug resistance reversal in BCSCs RICTOR SUFU DHH SHH BCL2 SMO PTEN ABCG2 CTNNB1 FADD PMC5482964__F3 Signal transduction by BG HEL-S-92n TBK1 TIRAP TLR4 IRF3 TRAF3 TRAF6 IRAK4 PMC11434829__F1 Simplified overview of the omega-6 and omega-3 PUFAs metabolism, focusing on the AA metabolic pathway components with relevance in CF COX2 LTC4S PMC6940896__F13 A sketch map of immunoregulatory induced by LTAa TRAF6 IL1B MYD88 PMC9051099__F8 MyD88 signaling in HSCs in fibrosis model CXCR3 NOS2 STAT1 JAK1 CXCL10 TNF MYD88 PMC8899859__F10 Obstructive Sleep Apnea Affects Lacrimal Gland Function FAS NR1C1 CD36 HIF1A PMC9208186__F7 Blockade of the Arid5a/IL-6/STAT3 axis underlies the anti-inflammatory effect of Rbpjl in acute pancreatitis STAT3 ARID5A RBPJ IL1B PMC4490005__F3 Vav1 regulates T cell activation through a feedback mechanism and crosstalk between the T cell receptor and CD28 CSA2 JUN PTEN VAV1 FOS PLCG1 FYN BCL10 CSK ITK GRB2 REL LCK PMC7016661__F2 TNF-TNFR2 signaling pathway RIPK1 TNF TRAF2 PMC7300552__F1 ACE2 function and its regulation in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection TMPRSS2 ATR ACE2 PMC4306584__F7 Extracellular Hsp90 mediates an NFKB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment STAT3 RELA PMC11009184__F7 Translatability of mouse muscle-aging for humans: the role of sex PIK3C2B AKT3 MTOR IRS1 PMC11843152__F7 NCAPH Promotes the Proliferation of Prostate Cancer Cells Via Modulating the E2F1 Mediated PI3K/AKT/mTOR Axis CDC2 MTOR CCNB1 PMC3309942__F1 Interaction motifs and domains of RANKL signal intermediaries COIL PTMS TRAF6 PMC10216531__F1 The fundamental parts of TLR4 signaling RIPK3 TBK1 TIRAP TLR4 CD14 IRF3 TRAF3 TRAF6 LBP MYD88 PMC5842063__F1 METABOLIC SWITCHING AND CELL FATE DECISIONS: IMPLICATIONS FOR PLURIPOTENCY, REPROGRAMMING AND DEVELOPMENT KLF4 LIF MSC HIF1A MYC SIRT1 PMC4291019__F6 ARF6 inhibition stabilizes the vasculature and enhances survival during endotoxic shock TIRAP ARF6 IRF3 MYD88 PMC3309942__F2 p62 in osteoclast signaling and protein trafficking TRAF6 CYLD PMC4053506__F8 D-PDMP inhibits ox-LDL induced LCS activity and atherosclerosis development LPL HMGCR CD36 CYP7A1 SREBF2 ABCA1 PMC8208232__F1 Cross-talk between lipid homeostasis and endoplasmic reticulum stress in neurodegeneration: insights for HIV-1 associated neurocognitive disorders (HAND) TG PC EIF2A PMC11546859__F12 Analysis of the pentose phosphate metabolic pathway HEL-S-304 HEL-S-41 PMC11546859__F11 Analysis of the glycolysis/gluconeogenesis metabolic pathway DLAT HEL-S-162eP PDC DLD PMC3421730__F6 The antiviral IFN response in infected THP-1 cells TBK1 JUN MAVS TANK IFNA4 IRF3 TRAF3 TRAF6 PIN1 IFNG RIPK1 ISG15 UNK FADD PMC9196867__F1 Current Concepts on Pathogenic Mechanisms and Histopathology in Cutaneous Lupus Erythematosus CXCR3 TBK1 CGAS PDC TNF MYD88 PMC4349428__F2 The relationship between genotypes and phenotypes of the nucleotide excision repair pathway and risk of SCCHN ERCC1 XPA XPC PMC8304822__F1 Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer WIZ PTEN PMC9463785__F1 Weipiling decoction alleviates N-methyl-N-nitro-N′-nitrosoguanidine-induced gastric precancerous lesions via NFKB signalling pathway inhibition STAT3 NTS CYCS HIF1A TYMS MYC CCL2 POR RB1 ABCC2 ABCB1 B2M VEGFA TNF FOS SST GHSR IGF1 GNA11 BCL2 BDNF HLA-A HEL-75 HEL-S-22 LEP CD36 PCNA GAS EGFR INS MPO CCKBR ALDH2 ADAM17 HLA-G INSR F3 DPP4 ELANE CDC2 BAX UBC JUN FASN PTGS2 IL6 GPC3 CYP1A1 RELA CASP3 NFE2L2 CFTR CREBBP EP300 CYP3A4 PMC3279601__F1 The Immunologic Revolution: Photoimmunology IL33 CXCR4 DDC CD207 CD1D PMC9463785__F3 Weipiling decoction alleviates N-methyl-N-nitro-N′-nitrosoguanidine-induced gastric precancerous lesions via NFKB signalling pathway inhibition PPARG PIK3CA NTS SPR CYP2E1 TYMS MYC CCL2 IFNG MMP2 MMP3 SRC ABCC2 ABCB1 MAPK1 NOS2 VEGFA TNF FOS YAP1 SST GHSR GSTM1 IGF1 CDKN1A FER CTSO GNA11 CDK2 BCL2 CXCR4 SIRT1 HEL-75 LEP CD36 GAS EGFR CXCL1 PTEN NR1C2 MTOR MPO CTNNB1 TGFBR2 CCKBR ALDH2 COL1A1 HLA-G INSR NR3A2 F3 IL18 IL2 TOP2A CDC2 BAX IL10 JUN EGR1 FASN RPS27A ARHA GPC3 CYP1A1 RAC1 PARP1 HEL-S-130P NFKB1 RELA PIR CFTR CREBBP EP300 CYP3A4 PMC9491525__F6 Putative BvrR/BvrS TCS regulon in B. abortus upon entry into the host cell PURA HEL107 PSD HEL-S-162eP PMC6913305__F4 Regulatory network of transcription factors in OA includes dark green quadrilateral module and light green rectangle module STAT3 MYB RFXANK RFXAP HIF1A ATF2 KDM4B SPI1 RB1 HOXA1 STAT1 ETV4 CREB1 NR1i1 ING4 SP1 STAT2 SREBF2 EZH2 BTF3 FOXF2 RUNX3 CEBPA BRCA1 HOXA9 EGR2 TRERF1 KLF4 KLF2 PGR RFX5 USF2 NUPR1 YY1 XBP1 CTNNB1 ATM POU1F1 ATF4 NKX2-5 JUN ETS2 EGR1 MEF2D ESRRA HMGA1 NFKB1 HOXA10 RELA EP300 REL PMC5002303__F2 Insulin signaling pathway RHEB TSC2 BAD FAS INSR FOXO1 GRB2 PDK2 MTOR INS PMC3004338__F4 Ingenuity Pathway Analysis (IPA) of differentially expressed genes between 24 DSS and 56 uncomplicated dengue patients RNASE3 STAR INCA1 RBM4 TFPI SELPLG SERPINA3 HEL57 TEF PMC7728626__F3 C-Jun N‑terminal kinase (JNK) activation in obesity-induced diet: NR1C1 NCOR1 FGF21 SOCS3 IL6 TNF PMC8763135__F3 Immune-targeted therapeutics and mechanisms of action investigated in major depressive disorder NLRP3 COX1 COX2 KMO IL18 IL6R PMC4945937__F8 Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway BAX GLS HEL-S-133P TIGAR MDM2 HEL-S-30 PMC10526115__F3 Why Is Iron Deficiency/Anemia Linked to Alzheimer’s Disease and Its Comorbidities, and How Is It Prevented? NGF ISCU AKT3 GSK3B ATF4 IL17A BDNF IRS1 PMC5659989__F1 Overview of the role of adiponectin in the crosstalk between AT and the cardiovascular system for the regulation of cardiovascular redox state RAC1 PMC2742468__F1 Metabolic cooperativity between oocytes and cumulus cells, and the role of oocyte-derived paracrine factors in promoting metabolism in cumulus cells BMP15 HEL-S-133P EBP SQLE SLC38A3 MVK PFKP HEL-S-49 PMVK ENO1 FDPS HEL-S-87p GDF9 PMC5529882__F3 Detailed molecular network of pathways of the cell cycle (Kyoto Encyclopedia of Genes and Genomes ID, has04110) RAD21 CDK7 PCNA CDC6 SMC3 SMAD4 CDK2 MYC SKP2 PMC10813163__F1 Schematic illustration of leptin-induced signaling pathways STAT3 MTOR PMC8613079__F1 Complement in metabolic disease: metaflammation and a two-edged sword HEL-S-62p C2 PMC11813047__F1 STAT3 signaling pathway STAT3 IL6 SRC PMC3749067__F1 Wnt/Beta-catenin signaling pathway APC GSK3B CTNNB1 PMC5621755__F2 AhRR with the canonical and non-canonical AhR pathways RELB AHR AHRR CCL1 PMC5621755__F1 Schematic illustration of the repression of the canonical AhR signaling pathway by AhRR AHR AHRR PMC10033548__F7 SFRP1 induces a stem cell phenotype in prostate cancer cells APC SFRP1 CTNNB1 PMC7522570__F9 Expression of orthologs annotated for the Kyoto Encyclopedia of Genes and Genomes (KEGG) tricarboxylic acid cycle (ko00020) pathway present in pleural ventral caudal sensory neuron (PVC) expression clusters with decreasing trend (P4 and P5) ACLY SDHA PDHA1 DLAT FH OGDH SUCLG2 PC DLD HEL-S-32 CS PCK1 PMC7522570__F8 Expression of orthologs annotated for the Kyoto Encyclopedia of Genes and Genomes (KEGG) glycolysis and gluconeogenesis (ko00010) pathway present in pleural ventral caudal sensory neuron (PVC) expression clusters with decreasing trend (P4 and P5) MINPP1 ADPGK PCK1 PGAM4 ACSS2 ADH1A PDHA1 DLAT HEL-S-68p HEL-S-49 HEL-S-162eP FBP1 DLD ENO1 GCK PFKL HEL-S-87p HEL-S-165mP PKLR PMC4753283__F1 The kynurenine pathway of tryptophan catabolism and markers of interferon-Gamma-mediated immune activation HEL-S-90n KYNU KMO PMC7651821__F2 Tumor progression by E3 ligases and DUBs CDC20 COPS5 APC FASN BRAF PTEN MTOR TRAF6 SKP2 USP14 MDM4 RBX1 FBXW7 FOXO1 ERBB2 SKP1 MDM2 TRAF2 CYLD CCND1 PMC3894167__F1 Is Non-Homologous End-Joining Really an Inherently Error-Prone Process? MRE11A ATM PARP1 XRCC3 PMC2930641__F2 MAPK Signaling Pathway MAX ECSIT EGF JUND FAS RAF1 EGFR CD14 TRAF6 FLNA MEF2C NGF MAP3K7IP1 MOS NF1 PAK1 NLK GRB2 BDNF TRAF2 CDC25B PMC7185488__F3 Hypothesized Human Endogenous Retrovirus (HERV)-Mediated Activation Cascades Leading to the Pathogenesis of Multiple Sclerosis (MS) HEL-S-92n SAG TLR4 APC PMC1868540__F1 Canonical Wnt Signaling Pathway APC LRP5 CTNNB1 PMC3742224__F3 Structure of human cine-N-methyltransferase (GNMT) gene in connection with scheme of sarcosine genesis in biochemical pathway HEL-S-182mP PMC7107779__F7 Diagram revealing the impact of p62 on the initiation and development of tumors in prostate tissues through the Keap1/Nrf2/ARE pathway KEAP1 GCLM NQO1 PMC1551980__F4 Ubiquitin Signaling in the NFKB Pathway TRADD BCL10 NOD2 TRAF6 TRAF2 MYD88 PMC1551980__F3 Ubiquitin Signaling in the NFKB Pathway TRAF6 CYLD MYD88 PMC2919275__F2 PD-1 Pathway in Tolerance and Autoimmunity PTEN MTOR PMC2919275__F3 PD-1 Pathway in Tolerance and Autoimmunity APC FOXP3 PMC4402192__F2 Role of antagonists in Wnt signaling pathway SOST APC GSK3B LRP5 LRP6 RHO PMC4402192__F1 Canonical and noncanonical Wnt signaling pathways APC LRP5 LRP6 RHO CP PMC5312537__F6 Changes in upper glycolysis, glycerolipid metabolism and pentose phosphate pathway during aging HEL107 GPD2 PFKP HK2 HEL-S-162eP FBP1 HEL-S-87p GPD1 PMC5843704__F8 Proposed model for the role of DAPK1‐mediated Beclin‐1 phosphorylation and TTP‐mediated Bcl‐2 mRNA destabilization in autophagy leading to the suppression of inflammatory responses by gAcrp in macrophages ADIPOR1 TRAF6 MYD88 PMC1551980__F1 Ubiquitin Signaling in the NFKB Pathway RELB TRAF5 REL TRAF2 PMC9035186__F3 Signaling cascades in the failing heart and emerging therapeutic strategies ARC FADD PMC9224119__F1 TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer TLR1 TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC8037234__F3 E2s participate in the DNA repair pathway FANCD2 PCNA RNF8 RNF20 UBE2T PMC10036296__F1 An Evolving Understanding of the Basis and Management of Vascular Complications of COVID-19: Where Do We Go From Here? CRP VWF ACE2 PMC12059369__F5 Key signaling pathways involved in the therapeutic mechanism of andrographolide (AD) in diabetic nephropathy (DN) TF STAT3 BAD REST EGR1 SELE ATF2 TNF MYD88 MMP2 APP NPB VCAM1 PMC3202988__F1 Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells OGA OGT PMC7984363__F2 HIF regulation and function on POMC RHEB TSC2 TSC1 POMC MC4R NPY AgRP TNF VHL EIF4E PMC12238214__F6 Hepatocyte nuclear factor 4-Alpha: a key regulator in liver carcinogenesis NR2A1 IL6 PMC12238214__F5 HNF4A Downregulation Drives Hepatocellular Carcinoma Proliferation and Genomic Instability: Downregulation of HNF4A promotes HCC progression through key molecular pathways NR2A1 CCND1 PMC6029659__F6 H2S targets key host factors and viral steps to perturb replication of enveloped RNA viruses SP1 TRADD KEAP1 IRF3 PMC8020248__F2 Dysregulated MET activation, signaling pathway, and tumorigenic consequence HGF PI3 EGFR IGF1R GRB2 CTNNB1 PMC6190278__F1 Heterologous effects of infant BCG vaccination: potential mechanisms of immunity EGF CD69 TLR4 CD14 MTOR PMC5386972__F2 MYC promotes anabolic metabolism HEL-S-133P HK2 MYC PMC8037234__F5 E2s participate in the NFKB pathway CD40 LTBR TRADD RELB TRAF3 TNF TRAF6 UBE2V1 HEL-S-71 BCR TRAF5 TRAF2 CYLD PMC5683310__F2 Molecular pathways regulated by ZNFs in physiological conditions KLF4 PPARG MYBPH PKP1 CDSN RCOR1 SPINK5 FLG RBBP8 HOMER3 CTNNB1 HDAC1 MYOG KDM1A MYOM2 CTBP2 CTBP1 KLF5 PPL MYL4 ZNF750 PMC6664754__F2 Proposed model of the Lgr5-mediated stimulation of cancer growth through activation of the Wnt/Beta-catenin signaling pathway LRP5 LRP6 GPR49 CCND1 CTNNB1 PMC8496198__F7 PI3KG/AKT Signaling in High Molecular Weight Hyaluronan (HMWH)-Induced Anti-Hyperalgesia and Reversal of Nociceptor Sensitization CD44 ARHA MTOR PMC9322180__F1 Genetics in Familial Intrahepatic Cholestasis: Clinical Patterns and Development of Liver and Biliary Cancers: A Review of the Literature FGF8A CYP7A1 FGFR4 PC CFTR NOTCH1 PMC6738120__F1 BRAF pathway EGFR BRAF PTEN GRB2 MTOR PMC5549800__F6 Vascular Endothelial Growth Factor A and Leptin Expression Associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors RHEB RPS6 TSC2 EIF4B TSC1 DDIT4 PC ELF3 EIF4E PMC6406361__F7 Main steps of arginine metabolism ASS1 ASL OTC PMC6943877__F1 Pattern recognition receptors and inflammasome sensing mechanism during influenza A virus (IAV) infection STAT1 MAVS NLRP3 TLR3 STAT2 IRF9 TLR7 IL1B MYD88 PMC9479306__F1 Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications CDC42 CDH2 TGFBR2 SMAD2 APC SMAD4 ZEB2 ARHA DROSHA CTNNB1 TGFBR1 PMC7104260__F1 Internal cues and the mating-pheromone-response pathway converge on the activation of Cdc42 CDC42 RAX2 FAR1 POLE PMC3429544__F8 Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition DRAM1 ERAL1 PMC2989726__F5 CFTR Chloride Channel in the Apical Compartments: Spatiotemporal Coupling to its Interacting Partners LPA CFTR NHERF2 PMC6406361__F1 TNF-related apoptosis-inducing ligand (TRAIL)-induced signaling pathways RIPK3 CASP9 MAP3K7IP1 MLKL TAB3 CASP3 RIPK1 TRAF2 FADD PMC6743792__F7 Executable pathway analysis using ensemble discrete-state modeling for large-scale data PPP1R12B PIK3CA RAF1 SOS1 SHC1 PARVG PXN PIK3CD PIK3R2 GSK3B PIK3R1 MAPK9 MAPK8 FLNA MAPK3 VEGFB FYN PDPK1 PI3 PRKCA FLT1 ARHGAP35 MAPK1 VAV3 ROCK2 FLNB ITGB7 CRKL HEL-S-28 VAV1 HEL114 ARHGAP5 CRK RAPGEF1 SOS2 PAK1 RAP1A BCL2 GRB2 IMPACT CDC42 BAD VASP PPP1CC PIK3R3 PIP5K1C AKT3 ZYX THBS3 BRAF IGF1R ITGAV MYLK4 PRKCB CTNNB1 MYLK CCND2 HEL-S-80p ROCK1 ITGA6 TLN1 MYL12B BIRC3 CCND3 ACTN1 ACTG1 JUN ITGA4 ARHA RAC1 ITGB1 ITGA1 ACTN4 MYL12A ERBB2 MAP2K1 BIRC2 PS1TP5BP1 PMC7937231__F8 Bacterial invasion of epithelial cells pathway (KEGG ID:hsa05100) in the CoPS vs HEL114 CRK CBL CLTA WASL HEL-S-28 ARHA PMC5751331__F1 Lysophospholipid-mediated PPARG signaling LPA ROS1 PLD2 PC PMC2782452__F1 Different views of the Akt pathway/network TEC BAD PTEN MDM2 MTOR PMC7540110__F1 Cell cycle regulation through cyclin E CDK6 SOX2 CDK2 CDK4 PMC7033644__F2 EV trafficking between leukemia and stromal cells reduces sensitivity to chemotherapeutics CXCR1 BMP2 MSC PC IL8RB PMC2644070__F2 Homologies between mammalian and insect immune defense pathways TRADD TRAF1 TRAF6 TRAF2 IRAK4 FADD PMC5290198__F7 BRD4 regulates breast cancer dissemination through Jagged1/Notch1 signaling BRD4 IL6 NOTCH1 PMC3616609__F2 The multi-step pathway of CENP-A-containing centromeric chromatin replication utilizing sequential, temporally separated steps across the mammalian cell cycle CDC42 CDC2 HJURP ECT2 APC CDK2 PMC7146499__F2 Dehydration alters hippocampal transcriptional networks KALRN IRAK1 DLGAP1 MIDN MBP ZFPM1 GAD2 SRC CSRNP1 GAA CYP51A1 PYGM HEL-S-133P JUNB APOE DLG4 VEGFA FOS BHLHB2 RELN DNAJC21 SYNGAP1 GPD2 BTG2 AFDN ARPP-21 PICK1 BDNF AVP DNAJB5 DLG2 SLC50A1 TH GRIA2 ARC HSD17B12 SIAH2 CASK CAMK4 NRXN1 PPP1R9A SIK1 SDCBP PER2 C1orf51 LYPD1 EGR4 PFKL NLGN3 PMC8316210__F8 Latent Membrane Protein 1 Promotes Tumorigenesis Through Upregulation of PGC1B Signaling Pathway NRF1 GABPA PMC3635124__F1 Shh signalling pathway1 KIF3A INTU HHIP CDON BOC C2CD3 IFT172 FUZ IFT52 ADRBK1 SPOP DYNC2H1 KIF7 SAP18 SUFU IFT57 PTCH1 DISP1 SHH SMO GAS1 GLI3 PMC2859499__F7 TAK1·TAB2·NLK complex negatively regulating canonical Wnt pathway NLK LEF1 PMC12133520__F2 Thymus cell development and regulation mechanism ID2 NFIL3 GATA3 RUNX3 PMC5666637__F5 Transforming growth factor B (TGFB) and bone morphogenetic protein (BMP) signaling in bone homeostasis SOST MMP2 MMP9 RUNX2 PMC5666637__F3 Summary of the bone morphogenetic protein (BMP) and growth and differentiation factor (GDF) signaling pathway and mutations causing connective tissue and skeletal disorders SMAD1 SOST DKFZp781O1323 LRP5 LRP6 RUNX2 PMC3276354__F1 Canonical Wnt (Wnt/Beta-catenin) signaling pathway (adapted from Ref RHEB SOST APC GSK3B LRP5 LRP6 MTOR TEF CTNNB1 PMC4355017__F6 Drugging the undruggable Ras: mission possible? GLUD1 RPE RPIA HEL-S-133P HEL-S-32 ENO1 ME1 HEL-S-30 PMC6085474__F7 Regulatory pathways of ERBB2+ GC NRG2 RARA ERBB2 MYC PMC6890986__F1 Apoptosis and necrosis pathways RIPK3 BAX MLKL RIPK1 PMC6890986__F3 Mitochondrial apoptosis pathway BAX BAD BMF HRK BIK PMC6890986__F7 Pyroptosis GSDMD MAVS NLRP3 PMC12070581__F9 Map of specific pathways under imazapyr acid stress SVIP LIG1 FEN1 PCNA PMC7072176__F3 Viral miRNAs affect the pathways involved in the carcinogenesis of host cells RUNX1 CASP3 PTEN CASTOR1 PMC6447583__F8 Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge IGF1 HES5 PMC6491837__F2 Positive and negative feedback signals for neuronal polarization CDC42 CDH2 SEMA3A TIAM1 IGF1 PAK1 NUMB LYN ARHA RHO BDNF PMC6604281__F1 Fanconi anemia curated map, based in the KEGG FA pathway ATR ATRIP RAD51 PMS2 BRCA2 FANCM FANCD2 RAD51C WDR48 POLK FAAP24 RFWD3 PALB2 REV3L PMC3701722__F1 Autophagy and endocrine resistance in breast cancer ATG12 ULK1 MTOR ATG5 PMC8490548__F2 MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility DHFR PMC11939858__F1 Influence of RANKL, sclerostin, and DKK1 on glucose metabolism and the corresponding signaling cascade DKK1 APC CXCL1 DPP4 LRP5 LRP6 TRAF3 MTOR CTNNB1 PMC5871764__F2 Notch pathway DTX3L NUMB PSEN1 HDAC1 CTBP2 APH1B CTBP1 CREBBP LFNG HDAC2 HES1 KAT2B HES5 PMC5871764__F1 Notch pathway DTX2 DTX3L NUMB DVL2 PSEN1 HDAC1 CTBP2 APH1B CTBP1 CREBBP MFNG HDAC2 HES1 KAT2B HES5 PMC3871277__F1 Panitumumab and epidermal growth factor receptor (EGFR) signaling pathway EGFR GRB2 MTOR SHE PMC6893313__F8 Representative model of the MMP-2 and MMP-9 secretion induced by leptin in a cultured model for breast cancer STAT3 SRC PMC8197283__F2 WNT4 Balances Development vs Disease in Gynecologic Tissues and Women’s Health FZD2 FOXO1 PRL HOXA10 IGFBP1 BMP2 LEFTY2 WNT4 EHD1 CTNNB1 PMC4518644__F5 Example of using “Effect on Metabolism” tool to see the overall proteome result mapped on carbon fixation metabolism OMD KEL MAL PMC4518644__F4 Example of using “Inter-pathways” tool to query interactions between two pathways (left─syn00710: Carbon fixation; right─syn00480: glutathione metabolism) EED LAP3 CP PMC6801436__F2 JAK1-TYK2 heterodimer signaling pathway IFNG STAT1 STAT2 JAK1 TYK2 PMC9358975__F1 Correlation Between MicroRNAs and Diabetic Retinopathy MMP21 CYC1 ATF4 NOTCH1 PMC7311964__F1 Wnt pathway drug targets MESD APC SFRP1 CTNNB1 PMC9185696__F1 Interplay of retinol binding protein 4 with obesity and associated chronic alterations FIS1 TLR4 RBP4 SOCS3 VCAM1 TRAF6 NOX4 MAPK6 MAPK3 PMC8402498__F9 Escherichia coli Alpha-Hemolysin HlyA Induces Host Cell Polarity Changes, Epithelial Barrier Dysfunction and Cell Detachment in Human Colon Carcinoma Caco-2 Cell Model via PTEN-Dependent Dysregulation of Cell Junctions HEL-S-11 MYC PMC3552883__F8 Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells MAPK1 MCL1 ATG5 MAPK3 PMC3653120__F4 Effect of physical activity and obesity on the growth and development of colon carcinogenesis PCNA GSK3B MYC TNF CTNNB1 PMC3653120__F3 Effect of cigarette smoke on the etiology of colon carcinogenesis EGFR BRAF KRAS PMC1681473__F1B (B) The bow-tie architecture also exists at the signal transduction level TH LTA TIRAP IRF3 IL6 TNF GATA3 MYD88 HEL-S-92n STAT1 TLR3 TLR4 STAT4 TLR7 CD6 PMC4684962__F5 Methylome-wide Sequencing Detects DNA Hypermethylation Distinguishing Indolent from Aggressive Prostate Cancer NAPA GRAP2 NR2C2 ARHGAP1 ADORA2A NDUFB11 KEAP1 EDN2 CAB39 SLC1A3 PIK3R2 SMAD4 SCNN1D SPI1 IL6R GRB10 NDUFB1 NDUFA3 DRAP1 ACOX3 CELSR2 KSR1 RICTOR STX1B SUFU PRKX CPSF2 HOMER2 WNT8B IL10RB SNAP23 STK11 VAMP2 PMF1 AKT3 CNOT4 SCNN1A NR1C2 CSTF3 CELSR3 PDE4B TFRC ADAM17 INPP4B MED16 ACVRL1 CEBPB HEL-S-36 LRP8 PARVA PDGFA TBL1X PPP2R1A CXCL6 KDELR1 SFRP1 FGF7 B9D2 SDCCAG8 MAFF C1QA ADRA2C U2AF1 ERBB2 MED25 AATF CD79B CIB2 STARD8 STAG1 KDELR3 GNG12 NUMA1 SIN3B PRPF6 ASAP2 NDUFS6 ETV4 STM7 SMARCA4 SMARCC1 RAB27A TRIO ID2 CD8B1 LIMK1 PLAUR PMP22 NUP62 MIA GCS1 ELMO1 ARHGEF7 TUBA8 ELK3 STAG2 ADAR HEL-S-62p ITCH ZYX DCHS1 TNFRSF18 TGFBRAP1 ADD1 U2AF2 PCDH8 CEP41 NDE1 ITPR2 FGF6B TUBA1C PRKDC NCKIPSD DVL3 HNRNPC NUP98 GATA2 MYO1D SMAD1 NMT1 CD72 TLR9 FOXA3 SUPT5H CSNK1E TYROBP SYT2 STX1A SYBU TCF12 FLNB CLTCL1 CDH24 KHSRP LINGO1 MED24 DDB2 COLGALT1 SF3A1 BRF2 PLA2G6 EDN1 EDNRA ACTG2 ITGB5 CDK5RAP2 XPA ARID1A SLC34A3 CLNS1A NKAIN1 PIK3R5 NKAIN3 CGNL1 ABL2 MED26 SRSF11 FAM13B DNAL4 NUMB IGFBP2 DDX54 YY1 POLR3A PRKCH PLCG1 IFITM3 GPLD1 TADA2B SSU72 CLTC IFNLR1 ASIP CXCL13 SIK3 RPA1 CNOT1 IL2RB PSMD9 IKBKB PDCL AKAP9 LCK PRKD1 KLKB1 SHC1 TUBGCP6 KALRN MED13L COL17A1 HNRPR ID4 EIF4E1B PIKFYVE GAA BMPR2 ACVR2B RAD52 RHOBTB1 PCK2 POLA2 IRF2 MCM3 LAMB2 PML NDUFS8 GANAB MTOR GRIN3A ISG20 ERC1 CREB3L2 PLAT ARFGAP3 NDUFB7 ARHGEF2 TBL1XR1 CKAP5 MED13 NKD1 PLOD1 EGR1 GNG4 NUF2 APTX SOCS4 NGFR PAG1 KNTC2 TLR5 PRNP ATP1A1 DAAM2 SDC1 GNG3 PTP4A3 NFKB1 NFE2L2 PTPRE CPT1C JAK1 AP1B1 REL CAMK2G PMC9338328__F2 Radiotherapy combined with immunotherapy: the dawn of cancer treatment STAT3 SMAD4 FOXP3 PMC9338328__F5 Radiotherapy combined with immunotherapy: the dawn of cancer treatment STAT3 CXCL12 CCR2 CCL2 CXCR4 PMC9338328__F6 Radiotherapy combined with immunotherapy: the dawn of cancer treatment STAT3 TBK1 CGAS CCR2 IRF3 CCL2 PMC6128898__F9 Expression patterns of T IPP SQLE FDFT1 PMC7814595__F3 Different T cell subsets infiltrate the injured brain CXCL9 IL16 AREG PMC5536086__F1 Proposed model for UCP2-SIRT3 (uncoupling protein 2-sirtuin 3) signaling pathway on cerebral ischemia–reperfusion injury UCP2 SIRT3 ROS1 PMC8255631__F2 Autoimmunity as an Etiological Factor of Cancer: The Transformative Potential of Chronic Type 2 Inflammation CD80 IL13 APC IL4 CTLA4 PMC7814595__F2 Functions of T cell subsets in the acute and chronic phases after ischaemic stroke IL10 AHR AREG PMC7531772__F5 Genome of the Softshell Clam Mya arenaria and the Evolution of Apoptosis HTRA2 BAX CASP9 BAD FAS CAD CASP8 CASP2 TRADD CASP12 AIP HRAS NGF ATM ATF4 EIF2A HRK TRAF2 CASP10 DIABLO FADD PMC5666637__F2 Summary of the transforming growth factor B (TGFB) signaling pathway and mutations causing connective tissue disorders SMAD2 SMAD4 SKI PMC5312359__F7 MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells HOXD10 NF1 PMC3924561__F1 Functional Relevance of Biased Signaling at the Angiotensin II Type 1 Receptor HBEGF BAD EGFR ARHA EIF4E PMC7017938__F1 Opioid activity in cancer STAT3 TIMP1 COX2 EGFR MMP2 RHO MMP9 PMC6541264__F2 Molecular mechanisms involved in drug-induced liver injury caused by urate-lowering Chinese herbs AURKA FUS STAT3 EED SIRT7 SHC1 COPS5 SMAD2 ATF2 FLNA MAPK3 HUWE1 BMI1 MAPK14 NPM1 RPL10 UNG HEL-S-1 SRC MCC TUBB FOS RNF2 CRK XRCC5 MAP3K1 NEDD4 BRCA1 RXRA ADRB2 HSPA4 CALM1 CDK2 HLA-B MCM2 VCAM1 GRB2 HLA-C NCL HEL113 PCNA TNFRSF1A EGFR IKBKE FBXW11 VCP IKBKG CSNK2B CTNNB1 STAU1 BTRC APP CLTC HEL2 YWHAG HSP90AB1 UBC JUN IQCB1 ARRB2 ITGA4 SOX2 PPP2R1A TERF1 HEL-S-30 NR3C1 VHL HDAC1 SMURF1 HEL-S-162eP PRKDC RELA HEL-S-102 NTRK1 RUVBL2 CFTR CREBBP EP300 TRAF2 PS1TP5BP1 YWHAZ PMC5700130__F4 Representative terpenoid biosynthesis pathway with cognate heat maps for transcript levels of genes from transcriptome data with substrates and products, colored arrows connect substrates to their corresponding products GGPS1 IDI2 IPP IDI1 PMC8584528__F1 Model Identifies Genetic Predisposition of Alzheimer’s Disease as Key Decider in Cell Susceptibility to Stress ATF4 EIF2A XBP1 PMC12246121__F11 Translation regulations in PRRs MAP3K8 TICAM1 ELF2 EIF5A EEF2 MTOR TNF CLEC4E TIA1 ELF3 EIF4E PMC3343135__F2 Differential expression of mRNA and proteins encoding factors in the Notch signaling pathway NUMB PMC5992987__F4 Putative signaling pathway composed of FOXM1, MYC and miR-34a MYB UBE2C PCNA NEK2 KIF20A CENPE MYC SKP2 FOXM1 NOP2 CCNE1 PHF19 E2F2 IGF2BP3 PRR11 RRM2 EZH2 LMNB2 PARP1 HDAC1 CCNE2 MTFR2 BRCA1 MCM3 MCM5 CENPA PMC12246121__F14 PRR in ageing HMGB1 CGAS TLR4 TLR9 TLR5 IRF8 PMC9106063__F7 ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NFKB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation NLRP3 TLR4 CD14 IRAK1 IRAK2 TRAF6 IRAK4 IL1B MYD88 PMC7573235__F4 Signaling pathways activated by AKT1(E17K) PIM2 PIM1 IGF1 HEL-S-28 PTEN TRAF6 IRS1 PMC7573235__F3 Signaling pathways activated by AKT PIM2 PIM1 IGF1 HEL-S-28 PTEN TRAF6 IRS1 PMC8391653__F2 Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation COL1A1 HEY2 SUFU SMAD2 SMAD4 LRP6 SMO RHO COL3A1 HES1 CTNNB1 ADA PMC1783691__F1 Differential Roles of Costimulatory Signaling Pathways in Type 1 Diabetes Mellitus CD40 ICOS APC PMC6338529__F1 VGF/BDNF/TrkB autoregulatory feedback loop stimulates synaptic plasticity changes in response to rapid-acting antidepressant treatment EEF2K AGO2 VGF HNRNPK BDNF PMC4172882__F1 (Rspo)s in canonical Wnt signaling pathway and the general architecture of (Rspo)s CR2 TEF CTNNB1 PMC2826212__F2 An intricate gene regulatory network controls OL differentiation HDAC1 TCF7L2 ID2 ID4 OLIG2 YY1 SOX10 OLIG1 HDAC2 HES5 PMC3646863__F4 Prognostic signature of G₂ checkpoint function in melanoma cell lines PTPRM ATR PSMB6 ANKRD28 ATF2 CTDSPL2 SETDB2 HERC2 HEL-S-42 CKS1B MNAT1 ATM FBXO5 CDC2 FOXA1 JUN DOCK10 APC KIT PSMD7 DAAM2 YPEL4 MMS22L HSF4 TWSG1 WDHD1 CDC25B KAT2B PMC9016174__F1 Endometriosis-Associated Angiogenesis and Anti-angiogenic Therapy for Endometriosis APC GSK3B CTNNB1 PMC6245608__F3 Physiological regulation of autophagy in the heart RHEB FOXO1 ULK1 FOXO3A F3 TFEB IRS1 PMC3988467__F1 Amino acid signalling upstream of mTOR RHEB MLST8 DEPTOR PMC8576330__F6 Involvement of the TGFB Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis TBR1 MMP2 TWIST2 IL11 MMP9 PMC6309606__F6 RAS/ERK, PI3K/AKT, WNT and Beta-catenin signaling pathways are involved in different stages of brain development and are commonly disrupted in ASD TSC1 GSK3B PTEN CTNNB1 PMC2826040__F5 miR-223 is implicated in the CREB signaling pathway IGF1 CACNA2D1 GPR108 IGF1R PMC2826040__F4 miR-200a is implicated in the type I interferon signaling pathway STAT2 IFNAR1 STAT4 PMC10526530__F2 What General Neurologists Should Know about Autoinflammatory Syndromes? IL10 CGAS SMS NLRP3 OTULIN IL18 NOD2 TREX1 PSTPIP1 MVK PMC6338642__F7 BMP4-mediated anti-cancer effects in ER+ breast cancer SMAD1 CDK6 DKFZp781O1323 BMP4 SMAD4 CCND1 CDK4 PMC8851529__F5 Alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents TF STAT3 EGF EPO MTOR VHL EIF4E HMOX1 TFRC TLR4 HEL-S-162eP EDN1 PFKL HEL-S-87p PMC5067143__F2 (Opposite and overleaf) Visualizing drug action STAT1 EGF EGFR PMC5647276__F2 Daily and annual timing share neurobiological and molecular pathways HLF TEF EYA3 PMC10874285__F2 Interplay between HCV-induced autophagy and host innate immune response TBK1 CGAS IRF3 TRAF6 PMC11707604__F3 Signal transduction via interleukin (IL)-4R complexes and mechanism of action of dupilumab JAK3 JAK1 TYK2 PMC8851529__F2 Alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents MLN CMA1 REN MME PRCP CPA3 CTSA MRGPRD CTSG ACE2 PMC10874285__F1 HCV inhibits the innate immune response SOCS1 TBK1 CGAS MAVS IFNAR2 IFNAR1 SOCS3 TRAF6 MYD88 PMC11707604__F1 Severe asthma immunopathogenesis in type 2 (T2)-high asthma and the specific targets of biologic therapies IL25 TSLP IL33 PMC7274521__F6 Schematic description of resveratrol-mediated suppression of inflammation in IL-1Beta-induced SW1353 cells IL16 TLR4 MYD88 PMC7267026__F3 Positive and negative regulation of MAVS activity antiviral immunity TRIM31 OTUD4 OGT TTLL12 MAVS NLRP11 FAF1 TRAF3 TRAF6 RAC1 TRIM21 SMURF1 TRAF5 UBXN1 NLK TRAF2 PMC7267026__F2 RLR signaling pathways MAVS TRAF5 IRF3 IRF7 TRAF3 TRAF6 TRAF2 PMC9048811__F2 Epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson’s disease TET2 SIRT3 PINK1 LRRK2 SNCA NRF1 PUM2 PMC3689575__F1 Modeling the genetic basis for human sleep disorders in Drosophila AMN CSA2 RALA PLAC1 REL RDX LBR PMC5347907__F3 Functional long noncoding RNAs (lncRNAs) in inflammatory pathways HNRNPAB HNRNPL TLR3 COX2 TLR4 SFPQ PMC8281237__F1 Amino Acid Metabolic Vulnerabilities in Acute and Chronic Myeloid Leukemias ASS1 ASL GLS CTH HEL-S-51e PHGDH BCAT2 SHMT1 BCAT1 PSAT1 PAH ASNS PRODH PSPH PMC9130726__F1 Molecular signaling pathways, pathophysiological features in various organs, and treatment strategies in SARS-CoV2 infection IL18 TNF IL1B PMC8076548__F8 Baricitinib Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway STAT3 STAT1 STAT4 JAK1 PMC6997398__F7 Pathological biological network construction of high calorie diet combined with pneumonia CRP HMOX1 CXCL12 NR1C1 METRNL TRIO PRL GHRL IL6 PSAP CCL2 SIRT1 PMC4444189__F6 MicroRNAs Regulate Cellular ATP Levels by Targeting Mitochondrial Energy Metabolism Genes during C2C12 Myoblast Differentiation NDUFS5 NDUFB7 COX6A2 NDUFS4 COX4I2 PMC6997227__F2 PI3K/PIP3 signaling activates Akt signaling via Akt/PDK-1 activation, which results in the downregulation of apoptosis IGF1 PTEN IRS1 PMC6429226__F5 Apoptosis can be modulated by the activity of polyphenols in prostate cancer C6 BAX BAD FAS C7 HEL-S-62p C2 C9 BMF APAF1 BIK FADD PMC6429226__F3 The effects of polyphenols on signaling pathways in prostate cancer TF EGF HGF IGF1 APC GSK3B PTEN SRC CTNNB1 PMC8998814__F4 Metastasis and MAPK Pathways CDC42 EGFR RAC1 PMC8998814__F3 Metastasis and MAPK Pathways CDC42 TBR1 EGF FOXC2 EGFR SMAD2 SMAD4 RHO GRB2 MTOR TRAF6 PMC2818318__F4 Regulation of Cell Cycle and RNA Transcription Genes Identified by Microarray Analysis of PC-3 Human Prostate Cancer Cells Treated with Luteolin CCND3 PCNA TFDP1 CDC6 GSK3B PI15 CCNA2 PLK1 SKP2 CCNH CCNB3 RB1 RBL1 CCNE2 CDK6 CCNE1 CCND2 CDKN1B WEE1 CDK2 CCNB1 CDK4 PMC8998814__F5 Metastasis and MAPK Pathways SOX13 FGFR1 FOXC1 PPP2CA ATF1 ATF2 SOX4 PMC8211510__F1 Huang-Pu-Tong-Qiao Formula Ameliorates the Hippocampus Apoptosis in Diabetic Cognitive Dysfunction Mice by Activating CREB/BDNF/TrkB Signaling Pathway CTRL DCD PMC5905170__F1 Summary of the workflow followed in the present study SET PMC9263770__F9 Yinzhihuang oral liquid protects against non-alcoholic steatohepatitis via modulation of the gut-liver axis in mice IL10 IL6 TNF IL1B PMC8909699__F2 Advance of SOX Transcription Factors in Hepatocellular Carcinoma: From Role, Tumor Immune Relevance to Targeted Therapy CXCL12 MTOR CTNNB1 SOX6 SOX9 FLT4 SRY FOXQ1 FGFR4 SOX18 ABCG2 SOX7 CCND1 SOX4 CYLD SOX17 FGFBP1 BAX SOX13 FRS2 SOX11 SOX12 SOX30 SGF29 SOX2 FZD7 SOX8 PMC5024698__F8 Mechanism for HKa-induced endothelial apoptosis and inhibition of angiogenesis CSK PAG1 LCK PMC4580722__F2 Regulation of autophagy by amino acids BAD MAP4K3 ULK1 UVRAG ATG14 BNIP3 IPMK PTEN DEPTOR ATG101 TSC2 TFEB AMBRA1 RS1 PMC4580722__F1 Autophagic machinery ATG101 WIPI1 LAMP2 RAB24 PIK3R4 ULK1 WIPI2 AMBRA1 ATG14 PMC3340168__F13 Apoptotic and necrotic targets modulate viability of epithelial responder cells by eliciting multiple recognition-dependent signaling pathways BAD GSK3B CCND1 CTNNB1 PMC7848376__F6 A, On the left, the Neurotrophin signaling pathway (modified from KEGG hsa04722), showing genes targeted by miRNAs (n = 15) involved in its modulation BAX BAD RIPK2 PMC4032270__F3 Oak Root Response to Ectomycorrhizal Symbiosis Establishment: RNA-Seq Derived Transcript Identification and Expression Profiling TF MYB F2 CS PMC7848376__F5 A, On the left, HIF‐1 signaling pathway (modified from KEGG hsa04066), showing genes targeted by miRNAs (n = 16) involved in its modulation BAX BAD IL2 FADD PMC3577904__F3 Gene Expression Analyses Implicate an Alternative Splicing Program in Regulating Contractile Gene Expression and Serum Response Factor Activity in Mice HOPX EGR1 HEL-S-273 CASQ1 FHL2 FHL1 ACTA1 NPPB RCAN1 FOS PMC5363613__F6 Integrin A2B1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma FAT4 AXL CCND1 PMC7787797__F8 PTP1B in IFN-Gamma-induced neuroinflammation and 6-OHDA-induced neuronal death ELF1 SUI1 ELF2 BDNF PMC8235304__F1 Opportunities for Ferroptosis in Cancer Therapy SLC3A2 IPP HMGCR GPX4 GCLM GCLC FACL4 SLC7A11 HEL-S-64p PMC11009036__F1 Nonsense-mediated RNA decay pathway UPF2 SGA56M SMG1 UPF3B SMG6 SMG5 MAGOH PMC8844686__F6 Transcriptome analysis of inseminated sperm storage tubules throughout the duration of fertility in the domestic turkey, Meleagris gallopavo CSF1 PGR CMPK2 DHX58 C1QTNF4 CA8 EPHB2 GNPAT ITGA2 IFITM3 OASL EPSTI1 CCND1 GBP3 NMI ITGA4 IRF7 RSAD2 VEGFA SAMD9L IGF1 TLR3 CALHM6 STC1 CA9 PMC1992444__F3 Interaction map of the Notch signaling pathway IFNG MESP2 LFNG PSEN1 HES7 HES1 PMC3373577__F4 Increased Levels of BAFF and APRIL Related to Human Active Pulmonary Tuberculosis CD40 FAS NFKB2 TNFRSF1A SDC4 TRAF3 MAPK8 MYC IFNG RTN4R TNFRSF13C CRP GPC1 IL10 TNFRSF14 TFG CD40LG FURIN TNF NR2A1 FCER1G RELA CASP3 NFKBIA REL TNFRSF11B BCL6 PMC4609028__F1 Cell Cycle Regulators and Cell Death in Immunity ATR ATM PMC9511043__F4 Function and mechanism of histone Beta-hydroxybutyrylation in health and disease ACSS2 HDAC1 BDNF HDAC2 PMC7867063__F2 Roles of NRF2 in cancer metabolism MTHFD2 HEL107 GCLM GCLC ME1 PMC9196267__F3 Focusing on Formononetin: Recent Perspectives for its Neuroprotective Potentials BAX KEAP1 TLR4 GSK3B MAF APP ADAM10 PMC4161521__F6 NFAT5/REDD1/mTOR/Notch pathway model TSC2 TSC1 NFAT5 PMC11065696__F7 Mechanistic scheme of UBB in ccRCC SP1 VEGFA UBB PMC3996587__F1 Extended model for the cyclin/Cdk network driving the mammalian cell cycle CDC2 CDC20 WEE1 CDK2 SKP2 PMC7912633__F2 Activation of NFKB and regulation of downstream transcriptional antioxidant and pro-oxidant targets in the canonical pathway (adapted from [,,,,,,]) CRP MT3 BCR COX2 RELA GPX1 PMC7560826__F1 Janus-like role of proline metabolism in cancer PRODH PYCR2 PMC12222209__F3 Aberrant localization of glycolytic enzymes on cancer MDR BAX PGP KAT5 PCNA HEL-S-133P HK2 EGFR EZH2 CTNNB1 HDAC3 HEL-S-68p PFKP HEL-S-162eP BCL2 ATM CMTM6 ENO1 ABCG2 ABCB1 PMC9011221__F3 Critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review ATF3 GPX4 BAP1 HEL-S-89n SLC7A11 ATF4 HEL-S-64p PMC7560826__F3 Janus-like role of proline metabolism in cancer STAT3 ATF4 MTOR PRODH PMC7560826__F4 Janus-like role of proline metabolism in cancer BAX PRODH APAF1 PYCR2 FADD PMC7576031__F2 Protein tyrosine phosphatase receptor type D (PTPRD)—mediated signaling pathways for the potential treatment of hepatocellular carcinoma: a narrative review CD44 STAT3 EGF CXCL8 CTNNB1 PMC3064425__F2 Dietary agents on the extrinsic and intrinsic pathways of apoptosis in prostate cancer BAX FAS TNF FADD PMC3518132__F8 Alkylphospholipid (ODPC)-induced raft-based inhibition of cell signaling LAT PTEN GRB2 LAT2 PMC7576031__F3 Protein tyrosine phosphatase receptor type D (PTPRD)—mediated signaling pathways for the potential treatment of hepatocellular carcinoma: a narrative review ZAP70 STAT3 LAT MTOR PMC6258166__F6 Brain hyperserotonemia and Sert knockouts HTR1F MPG CPB2 EGFR SPATA2L BMP3 TERT RUNX2 TRIM68 MAPK3 LIPC KIF12 FBXO24 HTR1B OXCT2 DENND2D STAT5B SSC5D ANKFN1 AGBL3 CREB1 FGF23 MAPK1 CRB1 JUN RHBDD1 SP1 CNKSR3 KCTD11 ALG3 VILL CCL19 IGF1 TFPI ABCC6 PICK1 CP PMC8999556__F4 New Perspectives in Treating Acute Myeloid Leukemia: Driving towards a Patient-Tailored Strategy FLT3 KIT PMC6953121__F6 Schematic representation of the molecular interplay between S1T-dependent ER Ca2+ leak, ER stress, BAPP processing, and neuroinflammation likely contributing to AD setting and/or progression BACE1 APP ATF4 EIF2A PMC8980928__F6 Synovial tissue‐derived extracellular vesicles induce chondrocyte inflammation and degradation via NF‐KB signalling pathway: An in vitro study ADAMTS5 IL6 PMC9436901__F8 Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9/p38 MAPK pathway BCL10 ATG5 CARD9 PMC4544949__F1 The flow diagram represents the sphingolipid metabolism pathways both in mammals and in yeast SMS tmp_locus_29 MIP PMC7528698__F1 Transcriptional regulation of macropinocytosis AXL PMC8608863__F6 Molecular mechanism of Met against HCT116 cells CASP9 CASP8 CASP3 PMC3267756__F9 Coxiella burnetii Induces Apoptosis during Early Stage Infection via a Caspase-Independent Pathway in Human Monocytic THP-1 Cells BAX TRADD FADD PMC7600811__F13 Simplified representation of the Rho/ROCK signaling pathway FHOD1 PTEN RHO PMC4515393__F1 Ceramide metabolic pathways CERS3 CERS5 SMS CERS1 tmp_locus_29 CERS2 CERS6 PMC4662490__F3 Tracking sub-clonal TP53 mutated tumor cells in human metastatic renal cell carcinoma BAX ATR THBS1 FAS GADD45G PERP CD82 CYCS SFN PTEN MYC DDB2 ZMAT3 MDM4 TSC2 CCNE1 STEAP3 SESN3 CASP3 CDK2 ATM RPRM MDM2 PRCC PMC7600811__F12 Simplified representation of the canonical and non-canonical Wnt signaling pathway CDC42 ARHA RAC1 CTNNB1 PMC5772162__F2 Progranulin TMEM106B TFEB GRN BDNF M6PR PMC11489006__F3 Hippo pathway and crosstalk with other signaling pathways in CRC GIP TCF4 CTNNB1 PMC11489006__F2 Upstream regulators of Hippo signaling pathway in CRC LATS1 LATS2 MB PMC11489006__F1 Hippo signaling pathway LATS1 LATS2 PMC5661614__F3 Simplified signaling pathway network where Wnt/Beta-catenin, Notch and Hedgehog pathways, along with critical transcription factors including Bmi-1, c-myc, Slug and Sox9, interact with one another and contribute to the maintenance of MaSC state BMI1 SOX9 CTNNB1 PMC8630984__F1 Mapping the molecular architecture required for lipid-binding pockets using a subset of established and orphan GPCRs GPR32 PTGER2 PTGER3 TBXA2R LPA PTGDR GPR34 PTGER1 GPR87 GPR75 FPR2 PTGER4 PTGFR PTGIR PMC6249229__F5 13C metabolic flux analysis and RNASeq explain the overflow metabolism HEL60 tal-1 HK2 MAL HEL-S-32 TAL2 ENO1 CIT PMC8395233__F1 Repair Mechanisms of the Neurovascular Unit after Ischemic Stroke with a Focus on VEGF VCAM1 SRC RAC1 IL1B PMC2839281__F4 Pigmentation Pathway Evolution after Whole-Genome Duplication in Fish PAX3 EDN3 ASIP DCT KIT TYRP1 SOX10 LEF1 PMC9112456__F3 Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives SUFU SMO TUG1 PMC9112456__F1 Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives ADRBK1 KIF7 SUFU GSK3B SMO PMC3432272__F1 HIV’s double strike at the brain CCR5 CXCR4 PMC5003333__F1 Genetic Insights into Pulmonary Arterial Hypertension. Application of Whole-Exome Sequencing to the Study of Pathogenic Mechanisms ENG SMAD4 NOTCH3 KCNK3 PMC5069093__F1 Regulation of TLR folding, trafficking, and cleavage SCARB2 UNC93B1 TLR4 MAL TLR9 TLR8 TLR7 PIKFYVE MYD88 PMC10909982__F5 Wnt/Beta-catenin signaling pathway potentially contributes to PTC progress APC CCND1 CTNNB1 PMC2630471__F5 DAF-2 Insulin-like Signaling Pathway Independently Regulates Aging and Immunity SGK1 PTEN INS PMC6721659__F3 Signaling pathways downstream urokinase-type plasminogen activator (uPA) receptor (uPAR) and its co-receptors STAT3 PLG VTN SRC RAC1 PMC6997353__F2 Ferroptosis: past, present and future IREB2 IPP LOX STEAP3 KEAP1 GPX4 LPCAT3 HEL-S-102 FACL4 ALOX15 SLC7A11 ATG5 PMC7214843__F2 RAD51-mediated RF reversal (A) and an overview of replication fork restart mechanisms (B) POLD3 RAD51 DNA2 PCNA WRN PMC5011625__F5 Endothelial Mechanosignaling: Does One Sensor Fit All? TIAM1 VCAM1 ARHA RAC1 PMC8400620__F5 Comparative Pan-Genome Analysis of Oral Veillonella Species SDHB ME2 HEL-S-162eP DERA PC RBKS MCEE PMC3563505__F6 Functional partners of RB1 protein through STRING database RB1 HDAC1 RBBP4 TFDP1 E2F2 E2F3 CDK2 MDM2 CCND1 CDK4 PMC7725906__F6 Action mechanism diagram of MXSG EIF4B CASP8 IRAK1 IRF1 IRF3 IRF7 MTOR TRAF6 IRAK4 MYD88 RHEB STAT1 TSC2 TSC1 TLR3 TLR4 EMC1 TLR7 ACE2 IL1B FADD PMC9148527__F4 Plasmodium manipulates the expression of host long non-coding RNA during red blood cell intracellular infection LTBP1 TH CD81 DBP HGF SP1 SMAD2 SMAD6 SMAD4 NODAL ARHA TNF TGFBR1 BAMBI IFNG RBX1 FST TLR4 RAE1 SKP1 PMC8966751__F4 Expression and Regulation Network of HDAC3 in Acute Myeloid Leukemia and the Implication for Targeted Therapy Based on Multidataset Data Mining MALL GC APP HEL-S-11 CNP ARHA TRPC6 SRC GATA4 PMC4226790__F1 Development of mononuclear phagocytes CX3CR1 MAFB CD34 PMC6879860__F3 Schematic of the components of the integrated model CRH MAL MTOR CIT PMC9596219__F7 DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway DAZAP1 KITLG PMC8899159__F5 Sex‐related differential susceptibility to ponatinib cardiotoxicity and differential modulation of the Notch1 signalling pathway in a murine model PPARG NOS2 JUN TGFB1 SP1 HIF1A MYC IRS1 CTNNB1 IFNG FOXO1 NR3A2 RXRA NFKBIA PMC8213343__F1 Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies CD40 SYK CXCL12 COPE RELB MAL TLR9 IRF1 IRF3 CD19 MYD88 IFNG BTK TLR3 BCR TLR4 TLR7 LYN JAK1 PMC5849056__F1 Complement System and Preeclampsia MASP1 C6 CD59 C7 HEL-S-62p C2 C9 CD46 CD55 CR1 PMC3279748__F2 GSK-3 in NMDAR-LTD STAT3 BAX CASP9 BAD RALB RALA CASP3 KLC2 PMC9672095__F4 Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer’s disease with metabolic syndrome LPL IDE INSR BPI APC ABO WAPAL MCU SNCA APP ATP6 TNF PMC3432498__F1 Activation of the IKK-NFKB pathway by radiotherapy and chemotherapy ATM TRAF6 PMC2933845__F4 Genistein inhibits critical pathways in cancer invasion SMAD1 MAPKAPK2 PMC6925521__F1 NHEJ occurs at all stages of the cell cycle BARD1 RAD51 BRCA1 RNF168 INS PMC11512513__F3 Signaling pathway with UPS-related muscle wasting in cardiac cachexia IGF1 IGF1R IL6 MTOR TNF TRIM63 IRS1 PMC4795702__F2 Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I CPVL TCAP HEL-S-273 CTSS CSTB FLNA LIPA SERPINB3 MYLK SYNPO2 ACTA2 SLMAP NAAA TYROBP tmp_locus_29 CLU SYNM PTGS1 PIGK FHL1 KCNMB1 DMD CLUL1 LMOD1 PLA2G7 NRGN RRAGD SMOC2 LRRK2 PCP4 BPI APOE SLC22A3 CTSK TYRP1 FTH1 MT2A HEL32 PALLD GPNMB CCL4 PLTP IGSF6 ACTG2 CD68 PMC6051722__F4 Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides and Incident Cardiovascular Disease LPL TG LDLR PMC11633002__F3 Network constructed based on the interaction test within the small cell lung cancer pathway from KEGG LAMB2 PMC7189798__F2 Death receptor and mitochondrial apoptosis signaling pathways and blocking TNFR1-mediated apoptosis by c-FLIP TRADD ITCH BCL2 TRAF2 FADD PMC6815639__F7 Pathview analysis of the NFKB signaling pathway CD40 SYK LTA TRADD TIRAP LAT LTB NGF BCR IL16 ATM HEL-S-11 BOD1 MIP LBP BIK LCK PMC9497241__F1 From Molecular Mechanisms to Therapeutics: Understanding MicroRNA-21 in Cancer RAN DGCR8 AGO2 DROSHA PMC11551531__F3 NFKB signaling pathway in macrophage polarization IRF3 TNF MYD88 PMC11551531__F5 Notch signaling pathway in macrophage polarization HES2 HES1 HES5 MYD88 PMC10334824__F5 Prospective application of lncRNAs in the treatment of diabetic wounds PROX1 NLRP3 SOX9 EZH2 PTEN PMC11551531__F4 JAK/STAT signaling pathway in macrophage polarization SOCS1 STAT3 JAK3 SOCS3 PMC12223783__F11 Exogenous spermidine inhibits trastuzumab-induced cardiomyocyte pyroptosis Schematic illustration of trastuzumab-induced cardiomyocyte pyroptosis, and exogenous spermidine blocking the action of trastuzumab by promoting mitochondrial biosynthesis TFAM SIRT3 GSDMD PMC11551531__F6 TGFB/SMAD signaling pathway in macrophage polarization SMAD2 SMAD6 PMC12112249__F2 MDK oncogenic signaling network STAT3 NOS2 ALK GPC2 SDC4 MTOR NOTCH2 KRAS NCL CTNNB1 PMC7702235__F2 miR regulatory mechanisms in experimental VCID CDK5 VAMP2 SCN2A BACE1 GSK3B SNAP25 STX1A SYT1 PMC7251091__F8 Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway SP1 PTP4A1 MMP2 PI15 MMP9 PMC4051924__F5 Top-ranked signaling networks related to Na+/K+/2Cl- cotransporter 1 downregulation according to ingenuity pathway analysis FANCD2 SPC25 JUN JDP2 CDC20 E2F2 NCAPD3 tmp_locus_29 CDC45 CDC6 APC PRC1 PMC7762932__F1 PC and PE biosynthesis via two branches of the Kennedy pathway TNK1 HEL-S-29 PC CEPT1 CHKA CHKB PMC3735985__F1 Simplified schematic representation of the insulin and TOR signaling pathways as they have been described in mammals and for which orthologous components have been described in D TSC2 TSC1 PTEN GRB2 PMC7312033__F2 IL-33, as pro-inflammatory and regulatory, on the central nervous system, liver, cardiovascular system, and pulmonary system IL33 IRAK1 IL5 HEL-S-70p TRAF6 MYD88 PMC4046645__F2 Overview of molecular pathways of oxidative stress and potential points of intervention in T cells in SLE IL2 FOXP3 MTOR PMC6033382__F2 Identification of a gene-expression predictor for diagnosis and personalized stratification of lupus patients TREX2 IL1R1 TREX1 MYD88 PMC7432853__F2 Different mechanisms of crosstalk between pancreatic ductal adenocarcinoma (PDAC) cancer cells and cancer-associated fibroblasts (CAFs) AXL IGF1 LIF SHH NODAL PMC8706168__F9 Homophilic Interaction of CD147 Promotes IL-6-Mediated Cholangiocarcinoma Invasion via the NFKB-Dependent Pathway CSA2 CXCR1 IL8RB PMC10779012__F3 Mechanisms by which pitavastatin and metformin act to (A) turn cancer cells sensitive to chemotherapy and (B) help to revert the exhaustion state of CD8+ T cells HMGCR MTOR PMC10706934__F1 Hypothetic signalling pathway triggered by FK506 BMP10 SMAD1 DKFZp781O1323 PMC10779012__F2 Insulin-like growth factor 1 (IGF1) signaling pathway and major downstream effects on cancer cells BAD IGF1 IGF1R MDM2 MTOR PMC10779012__F1 Metabolism of cholesterol within an ovarian cancer cell ABCG1 HMGCR SQLE LDLR FDFT1 ABCA1 PMC9374094__F2 Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges IDO1 PC AHR PMC5055212__F6 Gene network construction MAX RALA AKT3 LAMB2 MMP2 SKP2 LEF1 PMC7413390__F5 Canonical pathway represented by differentially expressed proteins in the BALF between progressive and non-progressive sarcoidosis implementing Overlapping Canonical Pathway functionality in IPA CDC42 RHO PMC5452982__F3 Regulation of muscle growth and regeneration by the immune system CXCL9 HMGB1 IRF1 TNF TRAF6 CCL2 PAX7 MYD88 IFNG MYOG STAT1 MHC2TA TLR4 TRAF2 NOTCH1 PMC3132181__F2 Analysis of Individual Molecular Events of DNA Damage Response by Flow and Image Assisted Cytometry CDC2 BAX ATR BRCA1 PML CDK2 ATM PMC10745105__F6 Working model of GAH-dependent vascular repair SMAD9 SMAD1 MAP3K7IP1 DKFZp781O1323 SMAD4 PMC3132181__F1 Analysis of Individual Molecular Events of DNA Damage Response by Flow and Image Assisted Cytometry BAX RAD50 MRE11A BRCA1 H2AX ATM MDM2 PMC8004487__F3 Role of sphingolipid associated loci in major sphingolipid metabolic pathways SPTLC3 SGPP1 GLTPD2 CERS6 PMC8834450__F2 Punicic Acid and Its Role in the Prevention of Neurological Disorders: A Review BAX CDK5 APOE CYP46A1 MTOR PMC10937367__F3 Effect of uridine on disease through O-GlcNAcylation ID2 NEUROD1 FOXO1 APP MTOR PMC8148009__F3 Musashi–1—A Stemness RBP for Cancer Therapy? DBF4 CDK6 E2F2 E2F4 CDC45 E2F3 CDC6 CHEK1 CDK2 SKP2 CDK4 PMC7837592__F3 Understanding Patterns of Brain Metastasis in Triple-Negative Breast Cancer and Exploring Potential Therapeutic Targets HEL-S-133P EGFR SRC PMC6598292__F4 Main biosynthetic pathway for the biosynthesis of cellulose MAL PMC9029324__F2 Colorectal Cancer Diagnosis: The Obstacles We Face in Determining a Non-Invasive Test and Current Advances in Biomarker Detection BAMBI SOST INVS LEP ROCK2 RHOD APC CER1 SMAD4 RYK NLK PMC6712175__F10 Schematic depicting the role of the C/EBP-Beta-lcn2 signaling pathway in MA-induced microglial apoptosis BAX BCL2 LCN2 CEBPB PMC3270028__F6 Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling TBK1 MAVS IRF3 PMC6245940__F4 Dysfunctional HDL and atherosclerotic cardiovascular disease TG ABCG1 SCARB1 ABCA1 PMC6664293__F2 KEGG AD pathway LPL IDE CASP9 BAD CASP12 APOE GSK3B SNCA TNF CASP3 APP APAF1 FADD PMC6664293__F4 Network visualization of the calcium signaling pathway with expression and GWAS information CCK TACR2 ADRA1D CHRM3 PPP3CA SLC25A4 ADRA1B PDE1C PDE1B TOMM40 CALML3 GRPR P2RX6 RYR2 CACNA1A NOS2 SLC8A2 CACNA1C AGTR1 ERBB3 GNA14 PDE1A CHRM2 PLCB1 PTGER1 PRKX ADCY1 MYLK2 VDAC3 ATP2B1 HTR4 PPP3R1 TRPC1 ATP2A2 HTR2A MYLK3 PRKCB HTR6 CCKBR TACR1 CAMK4 PLCB3 CACNA1S P2RX5 TAC3 PHKG2 P2RX2 GNAL SLC8A1 CCKAR PLCE1 DRD5 CAMK2D SLC25A6 P2RX1 HRH2 PMC2774770__F1 IL-4 induces an alternate pathway for BCR signalling SYK CASP9 JUN BAD RAF1 BLNK ATF2 FOS BTK BCL10 LYN GRB2 SRC PMC6944396__F1 Schematic of the proposed pathways whereby mitochondrial dysfunction impacts chronic obstructive pulmonary disease pathogenesis RIPK3 PINK1 MLKL PMC7308236__F6 Electric Stimulation Hyperthermia Relieves Inflammation via the Suppressor of Cytokine Signaling 3-Toll Like Receptor 4 Pathway in a Prostatitis Rat Model TLR4 SOCS3 IL1B MYD88 PMC4515050__F2 Activation of complement system by the amyloid plaques and its dual role in neuronal death HEL-S-62p C1S C1R PMC4905256__F8 Hierarchical protein binding at the rDNA locus and intersections with SUMO SMC2 NET1 SMC4 PMC7199433__F1 Mammalian kidney development FOXD1 WT1 LHX1 GDNF SIX1 PAX8 SIX2 OSR1 RET EYA1 GATA3 PMC7290425__F2 Breast cancer cells use HSFs to drive various tumor-promoting mechanisms HSF2 HSF4 HSF1 ALG3 HIF1A RAB21 IER5 PMC7290425__F3 Hepatocellular carcinoma (HCC) cells use HSFs to promote metabolic reprograming and cancer invasion HSF2 HSF4 RECK HEL-S-133P HK2 HSF1 FBP1 HIF1A PMC8778098__F1 Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors CGAS CASP8 IRAK1 IRF3 EIF2A TRAF6 IRAK4 PMC10993167__F2 Related regulators of N6‐methyladenosine (m6A), 5‐methylcytosine (m5C) and N7‐methylguanosine (m7G) are involved in the signalling pathways of drug resistance during tumour treatment STAT3 MMP10 HOXA10 ALKBH5 WTAP METTL14 MMP3 PMC10993167__F5 Molecular mechanism of action of the FTO inhibitor 18097 SOCS1 BAX IGF2BP1 EPHA2 PML TIGAR GPX1 TPP1 ATG10 DDB2 TSC2 BTG2 FOXO3A COL4A1 SESN1 GLS2 GADD45A SESN2 MGMT PMC10993167__F6 FTO, ALKBH5 and pseudouridine synthase partial inhibitors and their inhibitory pathways are introduced SOCS1 RARA CEBPA IGF2BP1 ALKBH5 MYC ASB2 MGMT PMC8814829__F4 Comparison of porcine milk microRNA expression in milk exosomes versus whole swine milk and prediction of target genes TSC2 BAD BCR BRCA1 F2 MEI1 RBL2 CD19 MB MDM2 RAC1 PMC4052186__F2 Cross-talk between mitochondrial metabolism and the IIS pathway is required to trigger the mitohormetic response in C PTEN PMC10976794__F3 Schematic overview of LMNA mutant pathways and MAPK3/1 (ERK1/2) initiated changes in cardiac remodeling MAPK1 WWTR1 JUN FHOD1 SHH DUSP4 MTOR YAP1 LMNA MAPK3 PMC6061680__F1 Toolbar, graphical elements supported in SPV and the mTOR pathway RHEB RPTOR RPS6 PPARG TSC2 tal-1 PTEN INS PMC10976794__F2 Schematic overview of the Hippo signaling pathway SFN ARC YAP1 TEAD4 LATS1 MOB1A MOBKL1A LATS2 TEAD2 TEAD3 HEL-S-1 HEL2 YWHAZ PMC4068945__F4 Nrf2-mediated oxidative stress response pathway is altered at multiple levels by DNA methylation in COPD airways FTH1 RBX1 JUND AOX1 GSTM1 MAFG EPHX1 KEAP1 GSK3B PTEN PMC12187747__F2 ROS-induced cellular signalling in cancer cells HEL-S-22 BAX BAD SRXN1 PTEN SRC PMC6280103__F5 Cholesterol biosynthetic pathway and relative expression changes for genes encoding related enzymes MSMO1 EBP SQLE SC5D MVK HMGCS1 ACAT1 HMGCR PMVK MVD DHCR7 FDPS IDI1 FDFT1 HSD17B7 TM7SF2 PMC5003378__F9 Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems CD14 IRAK1 TRAF6 REL IRAK4 MYD88 PMC7925335__F2 Airway and small intestinal tuft cell signaling GNG13 LTC4S CHRM1 CHRM3 GNB1 IL25 GNAT3 ALOX5 CHRM2 TRPM5 SI PLCB2 SUCNR1 ITPR2 ChAT PMC471568__F2 Schematic illustrating the current working hypothesis on the hormonal servomechanism regulating uterine gland morphogenesis and function in the ovine endometrium during pregnancy PRLR JAK1 GHR TYK2 PMC11905258__F6 Potential therapeutic role of MSCs and EVs in treating CKD HGF TIMP1 PCNA SMAD2 MSC MMP3 CD1C CCL5 MMP9 CCL2 TNF PMC6448884__F5 GTS-21 has cell-specific anti-inflammatory effects independent of A7 nicotinic acetylcholine receptors TLR4 IL6 TRAF6 TNF TRAF2 MYD88 PMC4807992__F1 Prostate cancer stem cells: the role of androgen and estrogen receptors DYRK1B SRC CCND1 RAC1 PMC11545229__F8 ENAH-mediated OSCC progression TF EGF EGFR APC GSK3B SRC ITGB5 CTNNB1 PMC2716750__F1 Gene regulatory networks in kidney development ROBO2 FOXD1 SLIT2 GDNF FOXC2 C2 PAX2 BMP4 FOXC1 SPRY1 RET PMC4813636__F1 Direct and indirect inhibition of MYC TRRAP MAX BRD4 MYC NCL PMC9595552__F4 Pyruvate metabolism–original version ACYP1 HAGHL FH LDHB ACACA ME1 HEL-S-30 ACOT12 ALDH3A2 ACSS1 ME3 PCK2 ACSS2 ACACB ACYP2 DLAT ACAT2 ME2 ALDH7A1 PC LDHD MDH2 HAGH PKLR PMC2882796__F1 Does Activation of the Blood Coagulation Cascade Play a Role in Malaria Pathogenesis? TF VCAM1 IL1B PMC7697007__F7 TRIP12 in the DNA damage repair (DDR) pathway in response to DNA double-strand break (DSB) [,,,,,,] BRCA1 RNF168 RNF8 ATM TRIP12 PMC7697007__F6 TRIP12, ARF, and P53 pathway TRADD MDM2 TRIP12 PMC10559929__F5 Explain the correlation among the chemical components, candidate targets, involved pathways and corresponding pharmacological effects of AGNHW HEL-S-22 ANXA1 MIF MMP9 TNF CXCL10 IGF2 PARP1 HMOX1 STAT1 RELA CASP3 BCL2 MAPK10 ABCG2 CEBPB HEL-S-44 PMC7911310__F1 Methionine metabolism AMD1 HEL-S-182mP SMS SRM HEL-S-61p PMC4097023__F6 Working model of apigenin-induced DNA damage BACH1 RAD1 FEN1 E2F2 H2AX ATM MYC PMC3696572__F1 Linking MLL and the HGF-MET signaling pathway in liver cancer HGF PMC12119490__F2 Tumor-derived vesicles and induced signaling modulation in various immune cells STAT3 CXCL12 JUN TLR4 ATF4 CXCR4 PMC6002513__F3 SIRTl/PGC-1A (FNDC5) pathway FNDC5 APP BDNF PMC10996278__F5 Major TCR signalling pathways CDC42 SOCS1 ARHH ZAP70 JUN RNF7 LAT CUL5 CD5 VAV1 PTPN6 FOS SLA2 PLCG1 FYN DGKA BCL10 RELA UBASH3A ITK GRB2 DGKZ LCK PMC9114485__F2 Pathways Linking Nicotinamide Adenine Dinucleotide Phosphate Production to Endoplasmic Reticulum Protein Oxidation and Stress MTHFD2 MTHFD1 SHMT1 ME1 HEL-S-51e PMC7419058__F1 P53 activity by FBXO22 during senescence KDM4A PHF20 FBXO22 PMC8804006__F1 Metabolic Transporters in the Peripheral Nerve—What, Where, and Why? PANX1 PANX2 HEL-S-133P PMC10996278__F6 Critical genes and signalling pathways engage in T cell anti-tumour responses SOCS1 BATF LTBR CUL5 PRDM1 CARD11 SOCS3 IRF4 GATA3 BCL10 RELA TOX FOXP3 PMC9040001__F6 Comparative transcriptomics discloses the regulatory impact of carbon/nitrogen fermentation on the biosynthesis of Monascus kaoliang pigments TG FAS CS PMC2913631__F3 Schematic model of crosstalk between PPARG and Wnt-5a signaling in MSC SETDB1 NLK PMC8888930__F1 Microglia Polarization From M1 to M2 in Neurodegenerative Diseases TLR4 TRAF6 SIRT1 MYD88 PMC6462501__F2 Signaling network of the MSC components related to protein synthesis and cancer ATR FAS ATM MTOR VEGFA SMURF2 TRAF2 CDK4 PMC8632544__F1 Wnt/Beta-Catenin-Dependent Transcription in Autism Spectrum Disorders JUN APC LRP5 LRP6 RYK ARHA RHO CTNNB1 PMC11545787__F1 Effect of Probiotics on Gastrointestinal Health Through the Aryl Hydrocarbon Receptor Pathway: A Systematic Review CYP1A2 AHR AHRR CYP1B1 PMC3793056__F5 Predictive metabolic pathway of biosynthesis in M DAP MTR STS PMC2581573__F1 The IL-1 signaling pathway TRAF6 IRAK4 MYD88 PMC6462501__F5 Systematic association of the MSC components with mTOR and DNA repair pathways ATR RAF1 PIK3R3 TNFRSF1A AKT3 GSK3B PIK3R1 PML MTOR DDX1 INSR RPA3 AIMP2 ATM EIF4A2 MAPK1 GOLPH3 RAD51 RRAGD SGK1 ATP6V1F RPA1 XRCC3 RHEB EIF4G1 PRKAA2 IKBKB ATP6V1E1 GRB2 PMC4552335__F6 Proposed pathways through which ethanol administration elicits alterations in cytokine gene expression HMGB1 TLR4 CD14 PMC9301130__F2 Effect of Lithocholic Acid on the Gut-Liver Axis NR1i1 FGF8A TH STAT1 STAT4 PMC6761006__F1 Glucose metabolism via hexosamine biosynthesis pathway links amino acid, fatty acid and nucleotide metabolisms to regulate cell physiology and pathology via protein O-GlcNAcylation OGA OGT PMC7040003__F5 Differential expressed genes in the hormone-mediated ovarian maturation pathways in the polychaete-fed group HEL-S-99n CDC20 GNRHR ATG12 APC PMC8107278__F1 Using Biosensors to Study Protein–Protein Interaction in the Hippo Pathway LATS1 MOB2 PMC8750061__F5 Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients MID1 HEL-S-102 PMC9606346__F7 Combined analysis of the transcriptome and proteome of Eucommia ulmoides Oliv. (Duzhong) in response to Fusarium oxysporum ELF2 BCL2 ATF4 PMC10856016__F2 Phosphatidylinositol 3-kinase (PI3K) protein kinase B (AKT)/mammalian target of rapamycin (mTOR), PI3K/AKT/mTOR, and mitogen-activated protein kinase (MAPK) signaling pathway activation in gastric cancer (GC) ERBB3 BAX PIK3CA BAD FOXO1 EGFR GC MTOR KRAS EIF4E FGFR2 PMC5652672__F3 Somatic mutations in salivary duct carcinoma and potential therapeutic targets PIK3CA ERBB2 PTEN MTOR PMC5652672__F2 Somatic mutations in salivary duct carcinoma and potential therapeutic targets PTEN PMC6489558__F7 Hypothesis: after surgery, PTFs can stimulate surrounding hepatocytes to transform into a malignant phenotype, leading to hepatocarcinogenesis and tumor recurrence STAT3 IL6 IL6R PMC9243434__F1 Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development MTOR BDNF XBP1 PMC5726598__F8 PIK3CA cellular signaling pathway TSC2 TSC1 EGFR PTEN MTOR PMC9011221__F1 Critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review IPP GLS FER STEAP3 GPX4 SLC38A1 HEL-S-64p PMC5007815__F7 MAPK/MSK1/Histone H3 pathway on target gene transcription EGR1 GRB2 ID1 PMC3847587__F5 Significantly affected canonical pathway “Interferon signaling”, as determined by IPA™ analysis IFNG BAX PSMB8 IRF9 IRF1 TAP1 JAK1 TYK2 PMC7068598__F2 Emerging signaling pathways in CSCs STAT3 IGF2BP3 EGFR IL33 SMO MTOR MYC SIRT1 UNK CTNNB1 PMC4489702__F1 miRNAs as biological and clinical determinants in colorectal cancer MACC1 CD151 PMC8106640__F6 PLPPR1 modulates RhoA-ROCK pathway PLPPR1 LPA ARHA PMC4090290__F1 Epidermal growth factor receptor (EGFR) pathway activation during HNSCC carcinogenic process STAT3 EGF TGFA COX2 EGFR MTOR PMC5458189__F7 Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head GSK3B MTOR CTNNB1 PMC10224166__F3 Anti-inflammatory effect and mechanism of atractylenolide I and III STAT3 TLR4 FPR1 MYD88 PMC3157425__F4 Apoptosis Induced by Piroxicam plus Cisplatin Combined Treatment Is Triggered by p21 in Mesothelioma FOXM1 LGALS3BP CDKN3 PMC10224166__F4 Anti-cancer effects and mechanism of atractylenolide I, II, and III CDC2 STAT3 BAX BAD TLR4 NQO1 MEI1 CDK2 MTOR MYD88 PMC4823096__F7 Novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells PADI4 SOX4 CIT PMC7671546__F8 G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor B2 in the rat hypothalamic paraventricular nucleus STAT3 GATA2 TSHB TRH PMC10138955__F5 Comparative Genomic Analysis of a Methylorubrum rhodesianum MB200 Isolated from Biogas Digesters Provided New Insights into the Carbon Metabolism of Methylotrophic Bacteria MAL ELL HEL-S-11 PMC7764203__F5 Metabolic pathways involved in lactate-based or ethanol-based chain elongation and production of acetate, n-butyrate, iso-butyrate, and n-caproate as predicted from the genome annotation of strains BL-3, BL-4, and BL-6 ETFA ETFB ADA PMC11355043__F1 Current model of the blood coagulation cascade, depicting NOACs’ mechanism of action TFPI APC PLG PMC7039088__F1 KEGG pathway map of the JAK-STAT signaling pathway obtained from the KEGG website GFAP MCL1 MTOR PMC5517452__F7 A putative signaling pathway of parkin expression induced by MIDN NGF MIDN PARK2 ATF4 PMC4949713__F3 WNT/B‐catenin signalling pathway APC GSK3B CTNNB1 PMC7784988__F6 Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration EGF TNC EGFR PMC8130321__F5 Signature RNAS and related regulatory roles in type 1 diabetes mellitus based on competing endogenous RNA regulatory network analysis CD2 GAS ISCA2 PWP2 PPP2R5C CS PIP4K2A EREG RAB27B INPP4A F2R EPOR YWHAZ PMC4992754__F1 Sonic hedgehog (SHH) signaling pathway FOXM1 CCND2 PTCH1 BCL2 SMO MYC CCND1 PMC10473922__F9 Huangqin decoction alleviates lipid metabolism disorders and insulin resistance in nonalcoholic fatty liver disease by triggering Sirt1/NFKB pathway FAS CD36 SIRT1 PMC8742202__F5 SMAD4 contributes to chondrocyte and osteocyte development SMAD1 FZD4 SOX9 PTHLH LRP5 SMAD4 IHH LRP6 PTH1R RUNX2 CTNNB1 PMC10906782__F8 Different biological activities of DCV-derived soluble CPE and sEV-CPE BCL2 HTR1E PMC9121642__F2 Compound Kushen injection inhibits EMT of gastric cancer cells via the PI3K/AKT pathway PPARG HPSE MPG PCNA ACACA MAP2 MTOR MYC POR PLAT NR3A2 IL18 CHUK APP ACHE BAX JUN NUF2 SELE HK2 CXCL2 VEGFA CXCL10 HEL-S-130P MVP PKIA CYP3A4 PMC2716751__F2 The concept of angiotensin II-growth factor cross-talk in ureteric bud morphogenesis FOXD1 GDNF EGFR WNT9B FGF10 ROBO2 FGF7 SLIT2 FOXC2 C2 PAX2 BMP4 FOXC1 SPRY1 PMC5516298__F1 FAM13A regulates the CPT1A–FAO pathway in chronic obstructive pulmonary disease (COPD) FAM13A HEL-S-5 CPT2 CPT1A PMC7526732__F4 Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women WFIKKN2 CELA1 BCAM IGFALS F11 IGSF8 PEX14 POSTN PRKCSH GNS AGR3 CST6 CELA2A CYP3A4 EFNB3 PMC9266892__F1 Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellitus APC GSK3B ARHA PMC7158706__F4 Upregulation of interferon signaling pathways SOCS1 BAX PSMB8 IRF9 IFIT3 IRF1 IFI35 IFNG HEL-S-162eP PIAS1 JAK1 GAS1 TYK2 PMC9220294__F8 Activation of the MAC1-ERK1/2-NOX2 Pathway Is Required for LPS-Induced Sustaining Reactive Microgliosis, Chronic Neuroinflammation and Neurodegeneration GP9 HMGB1 TLR4 MYD88 PMC8671294__F1 Purinergic Signaling in the Regulation of Gout Flare and Resolution NLRP3 PIR MYD88 PMC4138046__F1 Multi-Level Kinetic Model Explaining Diverse Roles of Isozymes in Prokaryotes HEL107 HPR GCA PMC6978517__F7 TGFB2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells CDH2 ACSL1 HEL113 DGAT1 CD36 SMAD2 ADFP PMC8226215__F1 Assembling Disease Networks From Causal Interaction Resources MAPK1 EGF EGFR GRB2 PMC8107841__F6 Investigation of the association between imbalance of the intestinal flora and infantile spasms: a pilot case-control study LIPT2 LIPM PMC8560834__F8 Incorporating Transcriptomic-Metabolomic analysis reveal the effect of ultrasound on ethanol production in Saccharomyces Cerevisiae PDC MDH2 PMC8254453__F6 Circulating mtDNA-mediated acute lung injury during sepsis due to STING-dependent autophagy dysfunction TBK1 CGAS TNF PMC3539261__F2 Initiation of the inflammatory response to monosodium urate crystals (MSU) by the innate immune system NLRP3 IRAK4 IL1B PMC9266554__F0 3-keto-DON, but Not 3-epi-DON, Retains the in Planta Toxicological Potential after the Enzymatic Biotransformation of Deoxynivalenol RAD52 CAST BAD REST CAD PYY BRCA2 BLM SSB RAD51B RAD51C MALL ATM HEL-S-11 PALB2 PMC3547110__F3 Amplifying phase TEC BTK PLCG2 BLNK TRAF6 GAB2 PMC5076476__F2 Pathogenic viruses target RLR regulation for immune evasion TBK1 MAVS TRIM25 PTMS ATG5 PMC5573165__F1 The polyamine-hypusine pathway AMD1 SMS SRM EIF5A SMO DOHH MYC DHPS PMC6321707__F1 Putative Celangulin V biosynthetic pathway in C IPP PMVK MVD IDI1 MVK PMC7797476__F4 CILP function and regulation in NP cells by TGFB and IGF-1 IVD IGF1 SMAD2 CILP PMC8786143__F1 Quantitative Alterations in Complement Alternative Pathway and Related Genetic Analysis in Severe Phenotype Preeclampsia CRP FH HEL-S-62p C2 CFHR1 VTN C4A C4B_2 PMC3077819__F2 Widespread extracellular matrix (ECM) pathway silencing by DNA hypermethylation in colon cancer NRCAM TIMP3 LAMA1 HEL-S-62p SPARC PLG HAPLN1 VTN CTNNB1 CD109 NTNG1 EVL GPNMB MMP3 FBN2 RET PMC3217183__F5 Signaling components of the RAS/MAPK pathway found to harbor activating mutations in various types of nevi and melanoma GNA11 BRAF PMC4418726__F3 RNA-Seq Based De Novo Transcriptome Assembly and Gene Discovery of Cistanche deserticola Fleshy Stem CAD PMC7999169__F6 mRNA-lncRNA co-expression network of the blue module ATAD2 BEST3 LMO2 ADM TNFSF13 IFITM1 CXCL2 FADS2 AREG GBP1 SPRY2 TRPS1 ATF3 EREG ISG15 TNFSF10 HES1 HIVEP2 PMC9277795__F8 circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3 ALDH1A3 AGO2 MTOR PMC3607621__F1 Dark face of AMPK as an essential tumor promoter ACLY FAS CAMKK2 ME1 HEL-S-26 PMC3336066__F2 Double-strand break repair in mammalian cells RAD52 ATR ATRIP RAD51 DNA2 BRCA1 ATM BLM PMC2805706__F3 Brain foods: the effects of nutrients on brain function IGF1 MTOR BDNF PMC11667780__F4 mTORis reduce the number and function of Tregs via multiple mechanisms to inhibit tumor progression RHEB TSC2 TSC1 FOXP3 PMC2842986__F2 General synthetic route to the racemic vinyl, ethyl, n-propyl, n-butyl, i-butyl, 2-propenyl, allyl, ethynyl, and 1-propynyl mevalonate lactone analogues (1a–e, g, i–k) is shown in C2 WAS RET PMC2984612__F1 Cellular FLICE-inhibitory protein: an attractive therapeutic target? FAS CAD FADD PMC4707216__F4 Met inactivation by S-allylcysteine suppresses the migration and invasion of nasopharyngeal cancer cells induced by hepatocyte growth factor HGF MMP2 MMP9 SRC PMC5128915__F2 THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer’s Disease TSC2 ATR PERP CCIN CASP3 CDK2 ATM PTEN MDM2 MYC STS PMC5166507__F1 Model for the cycling of ULK1 protein levels, which modulates the oscillatory mode of the autophagy response during prolonged starvation ULK1 MTOR PMC11667780__F3 Mechanisms underlying mTOR regulation in macrophage differentiation TSC2 TSC1 DEPTOR PMC7972846__F7 Effect of ECT on MAPK, AhR, and NFKB signaling pathways in CS-induced lung injury in mice IL16 AHR CS PMC3008185__F1 Two-loop model of iADE TH STAT3 TBK1 STAT1 STAT2 TRAF3 ISG15 JAK1 PMC11667780__F2 mTORis inhibit tumor metastasis to the lungs by suppressing EMT, tumor proliferation, and angiogenesis, whereas CNIs exert the opposite effect EPCAM MLST8 HIF1A DEPTOR PMC8146403__F1 Transport Proteins Enabling Plant Photorespiratory Metabolism PXN SHMT1 PMC5954140__F7 Gene regulation of ESRRG and Wnt signaling TCF4 CCND1 LEF1 NR3B3 CTNNB1 PMC3089562__F7 Proposed model of how endocardial Jarid2 expression regulates myocardial development NRG1 ERBB4 ERBB2 JARID2 CCND1 NOTCH1 PMC9393759__F2 Circulating inflammatory cells in patients with metastatic breast cancer: Implications for treatment CD40 CSF1 CCR2 SIRPA TLR7 FAP CD47 PMC6274312__F5 Interactomic analysis by Ingenuity Pathway Analysis (IPA) of significant molecules ECSIT TMEM97 H2AX ING5 RSAD2 CYP1A1 CD44 SEC31A IFNGR2 TSLP PLK3 HDAC10 NFKB1 PI3 IF2D RELA MAPK12 NRF SESN1 PMC11825815__F2 Macrophages in the progression of CP to PC: M2 macrophages interact with PSCs and contribute to the fibrotic process in the pancreas STAT3 EGF EGFR TNF PMC5119517__F1 The PI3K/mTOR signaling pathway RHEB TSC2 TSC1 PTEN PMC3875464__F3 PKG regulation of TRPC current and signaling RGS2 C6 HEL-S-62p TRPC1 RGS4 PMC11953522__F2 String pathway analysis of the significant genes with k means clustering → Red: apoptosis network (Bcl-2 family protein complex), yellow: Aspartyl transferase activity, Green: S100 protein pathway (1 CLEC6A MCL1 S100A8 PMAIP1 BCL2L11 SH2B2 BCL2L1 CBL BCL2L2 CBLC BMF S100A12 GRB2 S100A9 HRK BIK PMC4286392__F9 Notch and Eph / ephrin signaling pathways of non-myelinating oligodendrocytes relative to corresponding ones of their myelinating counterpart CXCL12 RAB14 HEY2 KALRN PLK4 SULF2 PELI1 GTF2B ASCL1 SUMF1 SMARCD3 NEO1 ASNS AGA CXCR4 GTF2F2 RET NOTCH1 PMC5579652__F1 MYD88-mediated TLR4 signaling pathway results in the production of pro-inflammatory cytokines TIRAP TLR4 CD14 IRAK2 IRAK4 MYD88 PMC8943949__F7 Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells CDH2 ELF2 CASP3 MMP2 MMP9 CCND1 CDK4 PMC4665974__F4 Overexpression of Human Fatty Acid Transport Protein 2/Very Long Chain Acyl-CoA Synthetase 1 (FATP2/Acsvl1) Reveals Distinct Patterns of Trafficking of Exogenous Fatty Acids PC PMC8160449__F1 Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection ATG101 NBR1 ATG3 ATG12 ULK1 ATG14 ATG5 ULK2 PMC6412963__F1 Overview of cholesterol trafficking in enterocytes ABCG8 ABCG5 NPC1L1 LDLR ABCA1 PMC6808435__F6 RNA-Seq analysis reveals an essential role of tyrosine metabolism pathway in response to root-rot infection in Gerbera hybrida PMC4590592__F8 Schematic view of the signaling pathways involved in healthy and CMML monocytes during CSF1-induced differentiation CSF1 CAMKK2 PLCG2 ULK1 P2RY6 PLCB3 PRKAA1 PMC7075910__F7 Protein interactions for ECM and summary of regulators TBX2 PCDH17 TGFBI LTBR HEL111 PBX1 SPARC IL33 ASIC2 CCL2 LOX CDH11 CFI OSMR COL4A2 CCL7 COL4A1 FLT1 FBN1 TIMP3 SP1 TGFBR3 NTRK2 RELN MASP1 BMP6 KIF26B TSLP CHPF2 IGF1 CHRM2 IGFBP7 TSHZ2 ERP27 COL21A1 TF BMP10 PTX3 HGF ST6GAL2 P4HA2 CD69 CD82 SRPX2 COL3A1 HTR2B TGFBR2 DCX SLIT3 COL1A1 CEBPD ADAM12 CNR1 HOXB2 ACVRL1 JUN FKBP7 COL1A2 SELE P4HA3 DPP10 SORCS1 COPZ2 GBP1 CD55 SLC5A7 HAND2 CHPF ENTPD3 KCNE4 TFPI DIPLA1 RELA IL6ST ROBO4 MCHR1 PMC8160449__F2 Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection TMPRSS2 NBR1 ACE2 PMC9184561__F7 Mechanism of sorafenib-inhibiting inflammation induced by LPS LYN IL6 TRAF6 LBP PMC10149254__F5 Chemical composition of pigeon crop milk and factors affecting its production: a review STAT5B PRL SOCS3 PMC7097628__F3 Rewiring cellular networks by members of the Flaviviridae family STAT3 OSBP STAT1 ATG16L1 HMGCR ATG12 STAT2 FASN ATF4 EIF2A XBP1 DDX3X PMC3427795__F1 Interplay between FOXO, TOR, and Akt RHEB TSC2 TSC1 IGF1 AKT3 F3 SESN3 PTEN EIF4E PMC7068675__F5 Candidate drug repurposing based on dysregulated lnc-FFLs associated with GDM BAD PIK3R1 EPO ATP1B1 PFKFB2 MYC FOS NR3C1 CTNNB1 ESRRA NRAS SLC16A10 NR1A2 CCND1 PMC6367546__F8 Schematic illustrating that CD9/ADAM17 axis plays a key role in keratinocyte migration via activation of EGFR/ERK signaling pathway EGF HBEGF ADAM17 CD9 EGFR PMC4621978__F9 D receptor‐mediated ERK1/2 activation via the PKCD/EGFR/B‐arrestin2 signalling pathway in response to specific agonist stimulation HBEGF EGFR SRC PMC2808051__F1 Summary of the insulin/IGF signaling pathway, using the terminology for mammalian systems BAX OGT ATM PTEN MTOR PMC3206266__F3 Androgen biosynthesis in the prostate HSD17B6 CYP17A1 CYP11A1 HSD3B1 AKR1C2 AKR1C1 PMC3281420__F1 Schematic overview of the multifunctional roles of c-FLIP in the TRAIL-triggered apoptosis pathway as well as activating various anti-apoptotic and cell survival signaling pathways TRAF1 TRAF2 FADD PMC2808051__F6 Mammalian target of rapamycin (mTOR) activation pathway RHEB EEF2K EIF4B C2 GSK3B EEF2 PTEN MTOR PMC8198874__F3 Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis CERK SMS B4GALNT1 PC B3GALT4 VILL PMC3756396__F1 Simplified scheme of the possible involvement of cAMP/PKA pathway in cancer SHH BCL2 MDM2 PMC7183669__F9 miR-135b-regulation of JADE-1 inhibited the growth of cancer stem cells and tumors in PC via the AKT/mTOR pathway SOX2 MTOR PMC4867329__F2 Molecular mechanisms involved in glucosensing in the gastrointestinal tract GIP TAS1R2 TAS1R3 PMC7289296__F4 1A, 25-dihydroxyvitamin D3 promotes the translocation of Beta-catenin from the nucleus to the plasma membrane, and competes with T-cell transcription factor 4 (TCF4) for Beta-catenin binding NR1i1 CTNNB1 PMC4737482__F1 Network mapping of genes with >5-fold expression change using IPA ENG BCL2A1 E2F4 NAB2 NEK2 RELA ETV4 CXCL10 DCN BIK PMC8348889__F1 SARS-CoV-2 and Acute Cerebrovascular Events: An Overview TF VWF TFPI PLG ACE2 PMC6604619__F10 Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor ACSL1 NR1C1 CYP8B1 CYP27A1 PMC5602287__F1 Summary of iAs effects on regulators of G1/(S)phase CCNE2 E2F2 CDK2 PMC8102306__F1 Intrinsic drivers of metabolic pathways RHEB TSC2 TSC1 HMGCR PTEN ENO1 GRB2 MYC PMC5285325__F3 Nuclear Dynamics of Heterochromatin Repair RAD52 SMC6 GC PML SMC5 PMC5499621__F10 The scheme for target of 4-O-Methylhonokiol on the TGFB pathway SP1 SMAD2 SMAD4 NOX4 PMC7146986__F9 Mechanism investigation of miR-195 in different stroke mediators, with a particular emphasis on the KLF5/ JNK axis CDC42 BAX SEMA3A CX3CR1 KLF5 PMC5085216__F8 Prevention effect of rare ginsenosides against stress-hormone induced MTOC amplification RAD51 BRCA1 FST GHB3 VHL PMC8450353__F7 Cyclosporin A: A Repurposable Drug in the Treatment of COVID-19? TMPRSS2 ADAM17 TLR3 MAPKAPK2 IL6 TNF ACE2 MYD88 PMC6470667__F1 IL-1, IL-36, IL-37, and IL-38 receptors and intracellular signaling IL1R1 IL1RAPL1 IRAK1 IL36A IL36B TRAF6 IRAK4 IL1B MYD88 PMC8194077__F1 Therapeutic Targeting of Notch Signaling: From Cancer to Inflammatory Disorders DLL4 JAG2 PMC4024417__F1 Crosstalk between TGFB signaling and the renin-angiotensin system in fibrosis TF SMAD2 SMAD4 ACE2 PMC2978721__F8 Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells DBI HEL-S-5 FACL4 PBR PMC6670035__F6 Proposed role of TGFB1 in HASM cell contractile responses in asthma SMAD2 SMAD4 AHR PDE4D ARHA PMC9695027__F3 NTRK Gene Fusions in Solid Tumors and TRK Inhibitors: A Systematic Review of Case Reports and Case Series GRB2 MTOR PMC6020112__F2 Mechanisms involved in osteocyte mechanotransduction LRP5 LRP6 PMC5815915__F8 Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis BAD GCLC BCL2 NOX4 PMC5867005__F1 UPR signalling pathway SP1 SP2 ATF4 EIF2A PMC7066582__F3 Retinoid signaling pathways leading to lung cancer stem cell (CSC) differentiation and cell cycle arrest RARA FZD2 RARB EGFR GATA6 MUC4 CCND1 PMC3995826__F2 Pathways for (A) Maturity Onset Diabetes of the Young (hsa04950), (B) type 2 diabetes (hsa04930), and (C) Notch signaling pathway (hsa04330); adapted from Kanehisa, et al CCK MAML3 INSR MAFA PRKCZ LFNG MFNG MTOR DLL3 INS MAML2 PMC7457384__F1 Source of IL-33 and the IL-33/ST2 signaling pathway IL33 MYD88 PMC6555088__F3 GSK-3 signalling in heart SMAD2 APC SMAD6 SMAD4 HEL-S-28 ARHA MYC CTNNB1 PMC4535771__F1 Using DeDaL for visualizing Fanconi pathway in breast cancer BLM PMC10949534__F11 Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use of Alchornea laxiflora (Benth.) Pax & K. Hoffm. for efficient treatment of depression MAPK1 STAT3 EGFR PIK3R1 SRC PMC10949534__F10 KEGG pathway analysis: (A) PI3K-AKT signaling pathway and (B) MAPK signaling pathway MAX TH SYK MYB BAD FAS TRADD RBL2 PTEN CD19 MTOR FLNA MEF2C TSC2 ENG CD37 APP NLK PMC6861014__F7 Model depicting the regulation of the host cellular response to systemic LM infection by C5aR1 and C5aR2 C5AR2 C5AR1 DDX41 PMC3061251__F1 Viral infection triggers the IFNB signal transduction pathway of the host innate immune system, activating the antiviral state STAT1 TLR3 STAT2 IFNAR2 IFNAR1 ELF2 TANK JAK1 TYK2 PMC6340394__F4 Black-Box Illuminated: Signals and Signaling CDK6 SIN3A NEDD4 GNS F3 NRARP MYC PMC10239166__F1 Transcriptional regulation on effector T cells in the pathogenesis of psoriasis IL2RA FOXP3 IL6R PMC8750102__F8 Amino Acid Metabolism in Cancer Drug Resistance GLS SLC7A11 PMC6068465__F5 p53 signaling pathway BAX TSC2 ATR FAS SIAH1 PERP CASP3 ATM PTEN PIGS MDM2 MYC PMC2637179__F2 Role of IRS-1 in insulin and IGF-1 signaling IGF1 CUL7 GRB2 MTOR IRS1 PMC8750102__F6 Amino Acid Metabolism in Cancer Drug Resistance PHGDH CTH PSAT1 PMC12152130__F4 Relationship between cuproptosis and autophagy FDXR DLAT ULK1 FES FDX1 MTOR ATP7B SLC31A1 PMC10377916__F2 Revisiting Estrogen for the Treatment of Endocrine-Resistant Breast Cancer: Novel Therapeutic Approaches STAT3 HMOX1 BAX FAS CASP8 CASP3 SRC TNF XBP1 FADD PMC7835541__F3 Effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification GRAP IRF9 TNF PMC4687794__F7 Signalling pathways downstream of CCK‐8s in pancreatic beta cells CCKAR BAD PMC6556479__F1 MC4R signaling pathway plays a vital role in regulating appetite and energy balance PMCH BBS10 SIM1 LEP MC4R MC3R ARC GNAS KSR2 PCSK1 POMC RAB23 SH2B1 NR1A2 NHLH2 BBS2 MAGEL2 BBS12 AFF4 LEPR NTRK2 BBS1 MRAP2 ALMS1 RAI1 BBS9 BBS7 PROK2 BBS5 BBS4 RPS6KA3 BDNF PMC3387006__F8 miRNA-mRNA Correlation-Network Modules in Human Prostate Cancer and the Differences between Primary and Metastatic Tumor Subtypes TGFBR2 CDC2 CDKN1A SMAD2 SMAD4 CDKN2B E2F5 CDK4 TGFBR1 PMC3387006__F7 miRNA-mRNA Correlation-Network Modules in Human Prostate Cancer and the Differences between Primary and Metastatic Tumor Subtypes LTBP1 TGFBR2 THBS1 ROCK2 FST ID4 E2F5 DCN TGFBR1 PMC8945680__F1 NFKB Signaling and Inflammation—Drug Repurposing to Treat Inflammatory Disorders? LTB MAP3K7IP1 BCR RELA RELB TRAF3 TRAF6 TNF TRAF2 PMC4052840__F2 Therapeutics in development that target survival pathways activated by LMP1 and LMP2a SYK FYN MTOR PMC3409438__F2 Broad receptor antagonism and attenuation of downstream signaling cascades mediated by decorin in tumor cells TIMP3 THBS1 CDKN1A MMP2 VEGFA MYC TNF IL12B CTNNB1 PMC8073517__F1 Adaptor Protein Myeloid Differentiation 88 (MyD88) in Post-Subarachnoid Hemorrhage Inflammation: A Systematic Review TIRAP IRF3 TRAF6 MYD88 PMC4348149__F1 Signaling-mediated Regulation of MicroRNA Processing DDX5 DGCR8 XPO5 AGO2 BRCA1 EGFR SNIP1 TUT7 TUT4 DROSHA PMC12195072__F4 In the kidney and parathyroid glands, FGF23 signaling requires the presence of FGFR (fibroblast growth factor receptor) and the coreceptor klotho FGFR4 PTH FGF2 FGF23 PMC6371191__F5 Role of PAK signaling in response to inflammation, altered microbiota and hyperglycemia JUN PAK1 TLR4 APC RELA GSK3B CTNNB1 PMC9260738__F1 Hypoxia-inducible factor-1A: A critical target for inhibiting the metastasis of hepatocellular carcinoma HIPK2 HIF1A VHL PMC12255092__F1 Cholesterol structure and synthesis HMGCR DHCR24 DHCR7 PMC12255092__F6 Therapies that target lipid metabolism TREM2 ABCG1 APOE ABCA1 PMC7016950__F8 Schematic outline representing neuronal adiponectin signaling pathway in the brain upon consumption of HFD GFAP LPO ADIPOR1 SYP IL18 PMC7093169__F2 Molecular mechanisms driving renal fibrosis are wide-ranging and complex, among which signaling pathways are very important APPL1 ADIPOR2 NOX4 PMC9318993__F7 Flightless I Negatively Regulates Macrophage Surface TLR4, Delays Early Inflammation, and Impedes Wound Healing TLR4 FLII MYD88 PMC6857536__F2 Role of Ras pathway proteins in exo-some biogenesis, cargo selection and release CDC42 TF EGF SP1 EGFR RHO GRB2 RAC1 PMC9513835__F7 Molecular Mechanisms of Spawning Habits for the Adaptive Radiation of Endemic East Asian Cyprinid Fishes ZP2 A2M PFN2 CS PMC3776053__F7 A model for mid-day contrast sensitivity regulation NPAS2 ADCY1 PMC4514180__F4 Signal transduction pathways drive cancer metastasis EGF HBEGF TGFA IGF1 IGF1R GRB2 SHE PMC6830116__F4 Signaling pathways involved in Epithelial-to-Mesenchymal Transition CDC42 CDH2 STAT3 EGF HGF HMGA2 EGFR SMAD2 RHO LATS1 LATS2 SNAI1 SUFU SMO PMC4514180__F2 Roadmap of peptide vaccine versus peptide mimic strategies TH NOG PMC3355967__F1 Schematic of exosome secretion in a cancer cell model RAB27A RAB27B RAB5A RAB13 RAB9A PMC7039994__F7 Chromatin accessibility is associated with the changed expression of miRNAs that target members of the Hippo pathway during myoblast differentiation DUSP8 ADORA2A RAF1 SOS1 BRAF DUSP9 FGF10 FGFR2 DUSP3 GNAS ADCY3 RASA2 MAP2K2 ADCY6 GRB2 RRAS2 PMC4276927__F4 Three intracellular signaling pathways are shown schematically RHEB PIK3CA TSC2 TSC1 NF1 MAP2K1 MAP2 MTOR MAPK3 PMC11855151__F6 displays the chemokine signaling pathway with all top-ranking lncRNAs and their interaction with pathway genes PER3 CRK REST BAD ARHA GRB2 SHE PMC11855151__F5 Antigen processing and presentation pathway (KEGG: 04612) displaying DE gene expression between AU and EU and the influence of the top-ranking lncRNAs in the prostate IFNG HEL-S-99n TAPBP CANX CTSL B2M CTSS SLC8A1 TNF PMC5819365__F1 Fanconi Anemia Signaling and Cancer ATM FANCM FAP PMC11855151__F9 Antigen processing and presentation pathway (KEGG: 04612) displaying gene regulation of AF vs IFNG TAPBP CANX INTS6 LIPE F11 SNAP25 TNF PMC8867096__F2 Unraveling Muscle Impairment Associated With COVID-19 and the Role of 3D Culture in Its Investigation CRP IGF1 ACE2 PMC8379503__F8 Impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation TFAM NMNAT1 NAMPT NRF1 SIRT1 PMC4496188__F10 The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1 EGF PAK1 EGFR SRC RAC1 PMC6671870__F6 The role of IDO/kynurenine in cancer immunoediting IDO1 FOXP3 PMC7327075__F1 Interaction between ferroptosis and lipid metabolism in cancer SLC3A2 LPO GPX4 LPCAT3 GC FACL4 SLC7A11 GLS2 HEL-S-64p ADA PMC6671870__F5 Sirtuins and epigenetic regulation of immune cell functions SIRT3 SIRT7 TLR4 SIRT4 SIRT5 SIRT2 SIRT1 SIRT6 PMC7534081__F1 Simplified schematic representation of the synthesis and metabolism of vitamin D.7-dehydrocholesterol in the skin is converted to previtamin D3 by UV-B and then is thermally isomerized to vitamin D3 CYP2R1 CYP27B1 CYP24A1 PMC7718039__F3 Mitochondria-mediated regulated cell death RIPK3 MLKL RIPK1 HEL-S-11 TNF PARP1 FADD PMC5722548__F1 CYP19A1 polymorphisms associated with coronary artery disease and circulating sex hormone levels in a Chinese population UGT1A1 CYP1A2 CYP17A1 SULT1A1 HSD3B1 HSD17B1 CYP1B1 CYP1A1 SULT1E1 PMC7039994__F4 Chromatin accessibility is associated with the changed expression of miRNAs that target members of the Hippo pathway during myoblast differentiation SNAI2 RASSF1 CSNK1D PPP1CC GSK3B STK4 PPP2CA DVL2 APC2 YAP1 LATS1 FRMD6 MYOG MOBKL1A WWTR1 FZD4 TEAD2 WWC1 PPP2R2A AXIN1 PPP2R2D HEL-S-1 WNT4 NF2 PMC8742449__F5 Induction and application of ferroptosis in cancer therapy STAT3 SLC3A2 RAB27A IL10 IFNGR1 TGFB1 GPX4 ARG1 SLC7A11 IFNG STAT1 IFNGR2 AGER JAK1 ATG5 PMC3768199__F1 Schematic overview of hippocampal signaling pathways following sleep deprivation CA3 SIRT7 USP2 PRKAA2 PRKAB1 MTOR RBM3 PMC2405914__F4 Catenins: Keeping Cells from Getting Their Signals Crossed CDC42 SHH RHO CTNNB1 PMC8051110__F10 Combination of RRM2 silencing and radiotherapy promotes the activation of cGAS/STING signaling pathway in LUAD cells CGAS RRM2 IRF3 CCL5 CXCL10 PMC5632571__F1 Transcriptional regulation of Th9 cell generation CD80 BATF APC IRF4 GATA3 PMC6044872__F2 Biosynthetic pathway of O-glycans ST6GALNAC2 ST6GALNAC1 DST ST3GAL1 PMC8669353__F3 DNA methylation profile of liver of mice conceived by in vitro fertilization ACLY BAD VAMP2 PTEN MTOR SOCS3 CRK PDE3B CBL GRB10 FYN INSR LIPE STX4A GRB2 PMC8533760__F1 ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer DUSP5 STAT1 HEL-S-61 SP1 PALLD KNS2 DUSP9 DUSP2 DUSP7 PMC8476258__F2 Association Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China STAT3 LEP PRKAA2 PRKAG3 NPY PRKAA1 PMC3786574__F2 Molecular mechanisms of T cell co-stimulation and co-inhibition CDC42 ICOS BTLA CTLA4 MTOR RAC1 PMC5520447__F8 The functions of miR-26a/b-Jagged/Notch axis in modulation of EMT and fibrosis SMAD2 SMAD4 PMC12210845__F6 Analysis of protein-protein interaction network of combined DEPs and DEPPs related to ABA signaling pathway under HS in nucleus (a) and in chloroplast (b) TEC ADA PMC8229348__F2 Description of the relationship in healthy longevity and aging-related disease: from gene to protein TG FOXO3A CYP7A1 KL MTOR MYC ATG5 FGF23 PMC12183514__F1 Mechanism of estrogen improving brain function, regulating lipid metabolism and alleviating osteoporosis TG IGF1 BDNF PMC8099713__F2 Host innate immune sensing pathway targeted by coronavirus TBK1 MAVS NUP93 IFIT1 IRF3 IRF7 MYD88 PMC4447342__F2 Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFKB Signaling in Hepatocellular Carcinoma NR1H4 SKIL CSF1 TNFRSF10B PXN HIF1A IRAK2 PELI1 MAP3K8 KDM6B CDK6 BCL10 ASAP2 ERRFI1 WEE1 PTPRH NFKBIZ ZFP36 NMI IFNGR1 IRF9 RBBP6 PLAUR TRIP10 ORM1 FOS ZC3H12A CDKN1A BRCA1 SMURF2 ELF3 VASP TGFB1 TNFAIP3 TNFRSF1A RELB ZYX SFN TNFRSF10A SHB CARD10 CEBPD ARHGAP21 PPARGC1A RND1 MAP2K3 BIRC3 RHPN2 THBS1 JUN CITED2 ETS2 PDLIM7 SPRY4 UBASH3B ZNF165 ID1 UBE2D1 CBL NR2A1 SMURF1 RNF43 RHOB NFKB1 NFKBIA KLF5 JAK1 TNFSF10 GATA4 BCL6 PMC8099713__F1 Sensing of RNA virus invasion by RLRs and TLRs TBK1 MAVS TLR3 TLR8 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC3263689__F2 VHL complex targets HIF-1A and HIF-2A for ubiquitin-mediated degradation RBX1 TGFA EGFR VHL PMC8099713__F3 Antagonizing IFN-mediated immune responses by coronavirus STAT1 STAT2 IFNAR2 IRF9 IFNAR1 IRF7 ISG15 EIF2A JAK1 TYK2 PMC3263689__F5 FLCN pathway TSC2 BAD FNIP2 FLCN PTEN FNIP1 PMC8224678__F1 Bovine Endometrial Cell Receptors and Signaling Pathways as a Nanotherapeutic Exploration against Dairy Cow Postpartum Endometritis NAIP NLRP3 TLR3 TIRAP TLR9 TANK TLR7 TRAF6 PMC6722770__F3A Prebiotics: Mechanisms and Preventive Effects in Allergy STAT3 MTOR CCL2 IL1B PMC4631758__F3 Gene regulatory networks involved in photoreceptor development NRL CRX FOXN4 PRDM1 NR2E3 OTX2 PTF1A RXRG VSX2 RORB PMC11015775__F1 Treatment algorithms of relapsing multiple sclerosis: an exploration based on the available disease-modifying therapies in China TH IL10 TGFA APC HEL-S-171mP IL6 PMC9479353__F5 Genetic regulation of RNA splicing in human pancreatic islets RPL8 GNAI3 GLP1R RPL19 RPL18A VSNL1 EIF3E GPSM1 RGS17 ADRA2A EIF3C EIF3D EIF3M RPS12 PMC7371520__F2 Caspase-1-dependent and -independent pyroptosis GSDMD AIM2 DFNA5 RHO IL1B PMC9552028__F1 Organoids as a Model System for Studying Notch Signaling in Intestinal Epithelial Homeostasis and Intestinal Cancer ATOH1 ADAM10 HES1 PMC8709313__F2 TKI Era in Chronic Leukemias CD79B SYK CD79A BTK PLCG2 BLNK CD19 LYN MTOR PMC8709313__F1 TKI Era in Chronic Leukemias JUN RAF1 BCR MDM2 GRB2 PMC7324530__F1 PI3K/Akt pathway in health (A), cancer (B) and AD brain (C) cells GSKIP PTEN IRS1 PMC8431328__F1 Influence of the Aryl Hydrocarbon Receptor Activating Environmental Pollutants on Autism Spectrum Disorder CYP1A2 AHR CYP1B1 CYP1A1 PMC7441741__F3 Tumorigenic mechanism in somatotroph cells GPR101 GHRH AIP GHRHR GIPR PMC3648157__F7 Dysregulation of cellular networks in the presence of PAN RNA expression DUSP5 TREM1 CCL22 TNFRSF1B PBX1 NR4A3 CDKN2B ULBP2 TNFRSF6B TACI TFF1 NLRP3 BCR NOD2 NOTCH3 PROC P2RX7 FAT10 FOSB IL18R1 NEU1 NGFR IRF7 PHLDA2 ATF3 BAG3 NT5E CCL4 STAT4 EGR2 PTGIR CARD9 ELF3 PMC5799368__F7 Model for the regulation of BMI1 on androgen receptor independently of PRC1 TMPRSS2 EED PRC1 MDM2 PMC3764819__F4 Enrichment of the Notch signaling pathway in glioma CSCs STAT3 ADAM17 DTX3 CTBP1 JAG2 DVL3 NOTCH3 RBPJ KAT2A NOTCH1 HES5 PMC7922135__F8 Hippo signaling pathway in OC (A) The main genes involved in Hippo signaling as regards OC and the associated miRNAs LATS1 TP73 LATS2 BBC3 TEF PMC3957914__F5 IFN-Beta-mediated regulation of PI3K/Akt/mTOR signaling and pharmacological agents active in this pathway RHEB MLST8 TSC2 TSC1 IFNAR2 IFNAR1 MTOR JAK1 TYK2 IRS1 PMC4302648__F4 Schematic plot of lncRNAs expressed in NSCLCs and their functions CDH2 TCF7L2 NKD2 MYC PMC6330346__F3 Rapamycin inhibits the de-differentiation of vascular smooth muscle cells FRS2 FGFR1 MTOR IL1B PMC8832753__F2 B-cell maturation antigen targeting strategies in multiple myeloma treatment, advantages and disadvantages SYK BAD RELB GSK3B BLNK PTEN CD19 TRAF3 BTK BCL10 PLCG2 PI3 TRAF2 PMC10770335__F3 Regulation mechanisms of KCC2 in mature neurons PLCG1 SMAD2 OSR1 BDNF PMC8832753__F1 B-cell maturation antigen targeting strategies in multiple myeloma treatment, advantages and disadvantages GC PC PREB PMC11001198__F6 Age-related changes after intracerebral hemorrhage: a comparative proteomics analysis of perihematomal tissue TF CREB3L3 STAT3 EGF MCOLN1 SLC40A1 MMS19 SMAD4 EPO HAMP IL6 SLC48A1 CIAO2B ERFE HMOX1 TFRC FES HFE HP CD163 CP PMC11001198__F5 Age-related changes after intracerebral hemorrhage: a comparative proteomics analysis of perihematomal tissue TF EGF MCOLN1 SLC40A1 EGFR SMAD4 EPO HAMP IL6 SLC48A1 ERFE HMOX1 TFRC GDF15 HFE HP CD163 CP PMC6096230__F1 NOTCH signaling and graft-versus-host disease JAG2 HES1 NOTCH1 PMC10308667__F2 Comprehensive insight into the correlation between ncRNAs and the Wnt/Beta-catenin signalling pathway in gastric cancer pathogenesis NKD1 DKK1 APC GSK3B CTNNB1 PMC10308667__F1 Comprehensive insight into the correlation between ncRNAs and the Wnt/Beta-catenin signalling pathway in gastric cancer pathogenesis APC ROR2 GSK3B ARHA RAC1 CTNNB1 PMC6096230__F2 Notch signaling in mesenchymal stem cells JAG2 FOXP3 HES1 NOTCH1 PMC10308667__F3 Comprehensive insight into the correlation between ncRNAs and the Wnt/Beta-catenin signalling pathway in gastric cancer pathogenesis BCL9 HMGA1 WNT3A APC GSK3B WNT1 CDK14 DKK2 SOX4 CTNNB1 PMC8028134__F6 Pathway of flavonoid biosynthesis in the leaves of C F2 F3 PMC4077930__F3 mTORC2 in the center of cancer metabolic reprogramming RPIA GLS HEL-S-133P PFKP HK2 PMC3070553__F11 Signaling modules identified by correlational analysis of end points STAT3 BAD GSK3A EGFR SMAD2 GSK3B MARCKS ERBB2 PTEN SRC CTNNB1 PMC7949100__F1 Central role of AR signaling in prostate cancer and targets in CRPC CYP17A1 CDK7 MED1 PMC5794831__F1 KEGG NFKB Signalling Network with dysregulated mRNAs highlighted and their associated miRNAs included SYK LTA LTBR TRADD TIRAP LAT TRIM2 TRAF3 TRAF6 DAO NGF BTK COX2 BCR TLR4 ATM IL1B CD14 BLNK LTB CNTF RIGI C2 LYN LBP TRAF2 PMC10121351__F8 Schematic of the molecular mechanism underlying UA anticancer activity in NSCLC cells STAT3 EGF EGFR SOX2 ABCG2 PMC4124246__F1 Signaling pathway induced by malarial ligand during liver-stage infection IFNG TBK1 ATR MAVS IRF3 IRF7 MYD88 PMC9654982__F1 Advancements on the Multifaceted Roles of Sphingolipids in Hematological Malignancies CERK SMS HEL-S-5 CER1 PMC4150215__F7 CREB-dependent cell cycle factor expression signalling network in GBM tumour cells PCNA CCNB1 CCND1 PMC10369979__F1 An oligonucleotide-based cGAS agonist for cancer immunotherapy NPS CGAS IRF3 PMC2879143__F4 Signaling cluster and integrin signaling REN EGFR TNF SKI NCL PMC4646463__F1 Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling RPS6 EGF HHIP SUFU EGFR PTCH1 SMO AREG MTOR PMC5492466__F3 Transcriptional changes of genes involved in basic metabolism in Bgt during asexual development on Chancellor HEL107 XK COQ4 CS PMC6693483__F2 Basic schematic representation of the cAMP-PKA pathway (green) and three MAPK pathways in Candida albicans which are important for morphogenesis, adaptation to stress and survival CDC42 TF TPK1 PMC7222375__F3 Main cell signaling pathway involved in red cell homeostasis SYK LYN PMC4568928__F1 Proposed model for multiple-target inhibitory action in TT cells BRAF PTEN GRB2 MTOR SRC RET PMC10304357__F1 Targeting cGAS/STING signaling-mediated myeloid immune cell dysfunction in TIME CGAS IRF3 TRAF6 PMC9490147__F5 DNA repair as a shared hallmark in cancer and ageing PNKP XPA ATR ATRIP SMARCAL1 RAD51 MRE11A DNA2 APTX ATM BLM XPC PMC8482189__F3 New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas CD40 KLF2 TNFAIP3 BCR TCL1A CARD11 TRAF3 NOTCH2 MAP3K14 MYD88 BIRC3 PMC7412551__F3 K-bZIP inhibits antiviral innate immune signaling and anti-proliferative signaling TBK1 CGAS CDK2 IRF3 PMC8482189__F4 New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas KLF2 TNFAIP3 TRAF3 NOTCH2 NOTCH1 MYD88 BIRC3 PMC1682015__F2 Example pathway structures based on Z-scores of reactions, which demonstrate the metabolomic response of the selected reactions in the reported case studies, namely, the effect of an altered redox metabolism and aerobic/anaerobic growth TH GAD1 PCK1 CIT PMC2879143__F3 Activation of apoptotic signaling via caspase 3 and gelsolin ROCK1 APC ACIN1 FNTA PMC6039341__F3 RAS signaling cascade and EMT: Growth factors including EGF, FGF, HGF, VEGF, PDGF, IGF act through RTKs and activate PI3K–AKT, RAS-RAF-MEK-ERK MAPK and SRC signaling cascade EGF PATJ GSK3B SPARC PTEN PALS1 ZEB2 SRC PMC5732092__F2 Interleukin (IL)-17RA/RC signaling pathways IL17RC TRAF5 TRAF6 TRAF2 PMC4538579__F1 BAFF-induced activation of NFKB signaling and increased expression of proinflammatory cytokines as procachectic mediators IL16 RELB TRAF5 TRAF3 TRAF6 TRAF2 PMC7606751__F1 Role of BCAA metabolism in cancer progression TET2 BCKDK PPM1K LAT MEIS1 SRC PMC9600986__F2 Recent Advancements in Molecular Therapeutics for Corneal Scar Treatment POR MMP9 PMC3504641__F1 Schema of the cholesterol pathway CYP51A1 EBP SQLE DHCR24 TM7SF2 PMC5436279__F5 Several roles of scrapie responsive gene 1 (SCRG1) suggested in this study and our previous reports SCRG1 CCL22 TLR4 CD14 MSC BST1 PMC4215229__F6 A model of FGFR4-mediated metabolic regulations FGF8A CYP7A1 FGF21 FGFR4 PMC11967072__F5 miRNA-mRNA regulatory network analysis and screening of the hub miRNAs SYK BAD GSK3B PTEN IGF1R MTOR MAPK8 RB1 BCL2L1 FBXW7 CDK6 CCND2 STAT5B BCR PRKCA CHUK MDM2 CREB1 MAPK1 EGR1 SP1 RBL2 CD19 IRS1 FGF2 RHEB CD44 TSC2 SCARB1 FOXO1 FOXO3A EP300 BDNF SIRT1 PMC5041020__F1 Leptin and jak-stat in cancer STAT3 BAX EGF CD2 EGR1 TGFB1 HGF LEP GHRH PTEN MMP9 MTOR VEGFA ERG TNF MYC RB1 STAT1 IGF1 MMP2 BCL2 EP300 TNFSF10 PMC3822800__F5 Diagram represents the molecular cross-talk between TLR2 heterodimers with TLR6/TLR1 and GR through the participation of PI3K TLR1 TIRAP MYD88 PMC2829067__F1 Caspase-1 Activation via Rho GTPases: A Common Theme in Mucosal Infections? CDC42 NOD2 AIM2 ARHA RAC1 IL1B PMC6125368__F2 Scheme of possible mechanisms by which autoimmune diseases are mediated by IGF-IGFBP signaling pathways PTEN MTOR IRS1 PMC4177473__F1 S-adenosylmethionine is produced from methionine by methionine adenosyltransferase HEL-S-61p PMC9409318__F7 Multiplexed Human Gene Expression Analysis Reveals a Central Role of the TLR/mTOR/PPARG and NFkB Axes in Burn and Inhalation Injury-Induced Changes in Systemic Immunometabolism and Long-Term Patient Outcomes ULK1 TLR5 ARG1 RHO EIF4E PRR5 RHEB TSC2 TLR1 TSC1 TLR4 TLR8 APP CP PMC3073847__F1 TGFB signaling pathway TGFB is secreted in a latent form and activation is mediated by several molecules including furin and emilin EMILIN1 TGFBR2 ENG SMAD1 DKFZp781O1323 SMAD2 SMAD4 MAP3K7 ACVRL1 FURIN TGFBR1 PMC7226514__F2 “Prion diseases pathway” from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database with genes significantly modulated in brain samples from ASD patients that have been color-coded from blue (downregulated) to red (upregulated) EGR1 NOM1 PMC8389414__F5 LM pathway analysis highlights upregulation of AA-derived LM in non-survivors patients LTB VIP GSTM4 PTGES PMC8389414__F2 LM pathway analysis identifies an upregulation in ALOX5 activity in patients with severe disease VIP GSTM4 PTGES PMC9681083__F9 Schematic for the plausible mechanisms by which PI3K pathway inhibition mediated the anti-leukemic activity of FD268 AML cells BAX BAD MTOR PMC4349374__F1 Molecular events in the autophagy pathway ATG10 ATG3 ATG12 ATG5 PMC11091328__F1 Regulatory mechanisms of SIRT1 on ER stress and NFKB signaling pathways ATF4 XBP1 SIRT1 PMC8530467__F1 Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity? TMPRSS2 TBK1 STAT1 MAVS STAT2 IRF9 IRF3 NOD1 ACE2 PMC4594309__F1 Neurogenic niches and Eph:ephrin signaling EPHA4 CCL1 CP PMC4674750__F3 Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs HEL-S-133P HEL-S-68p PFKP F2 HK2 HEL-S-162eP FBP1 PDC TP63 ENO1 PMC7269991__F1 SOCS family genes were re-analyzed by KEGG pathway enrichment GFAP PIM1 IRF9 MCL1 MTOR PMC3335938__F1 Key therapeutic targets in the PI3K/Akt and MAPK pathways together with pharmacological agents inhibiting members of these signaling cascades BAD PI3 AKT3 WEE1 PTEN MDM2 MTOR CCND1 PMC7910854__F8 Schematics of neural circuit involved in phototaxis behavior PDF TRPA1 PMC3727154__F1 Immunomodulatory functions of type I interferons STAT3 IL10 IFNGR1 IRF9 MTOR TBX21 IFNG IFNGR2 IFNAR2 IFNAR1 STAT4 JAK1 TYK2 PMC2697290__F1 Phenomics of cardiac chloride channels: the systematic study of chloride channel function in the heart CLCA1 CFTR PMC4292735__F1 Insulin growth factor 1 (IGF-1) signaling pathway TSC2 BAD RICTOR TSC1 IGF1 GSK3B IGF1R GRB2 MTOR DEPTOR IRS1 PMC4943968__F5 KEGG pathway (pathways in cancer) analysis with predicated target genes from all selected differentially expressed miRNAs CDC20 PCNA SMAD2 SMC3 SMAD4 ORC1L MYT1 ORC3 SKP2 ORC2 CDK7 E2F4 CDC45 CDK2 MDM2 PMC9385303__F10 Network Pharmacology Analysis, Molecular Docking, and In Vitro Verification Reveal the Action Mechanism of Prunella vulgaris L. in Treating Breast Cancer MAX FAS TRADD APP TNF PMC7884707__F4 Wnt/Beta-Catenin signaling pathway-mediated therapy resistance in CSCs CD44 BCL9 SMOC2 APC GSK3B LRP5 LRP6 ID1 SOX8 CTNNB1 PMC7884707__F3 Hedgehog (Hh) signaling pathway-mediated therapy resistance in CSCs KIF3A IGF1 SUFU SHH IL6 GLI3 PMC3243341__F3 Conversion of major constituents in the stem cuticular wax biosynthetic pathway HEL-S-62p C2 HEL-S-5 CS PMC7744569__F4 Summary of metabolic engineering performed to increase fatty alcohol production in S PEX10 POT1 ADH5 PMC7769624__F10 Development of a hybrid model for a partially known intracellular signaling pathway through correction term estimation and neural network modeling TLR4 TRAF6 MYD88 PMC5063567__F2 The Kynurenine Pathway Is a Double-Edged Sword in Immune-Privileged Sites and in Cancer: Implications for Immunotherapy AHR PTEN MIF TEF PMC12029365__F4 TME lactate signaling ALDH1A3 HCAR1 GPR132 GRB2 AREG MTOR ABCB1 PMC4943968__F4 KEGG pathway (pathways in cancer) analysis with predicated target genes from downregulated miRNAs CDC2 DBF4 PCNA CDC6 SMAD2 ORC1L MYT1 ORC3 SKP2 RAD21 CDK7 E2F4 CDC45 CDK2 MDM2 PMC4943968__F3 KEGG pathway (pathways in cancer) analysis with predicated target genes from upregulated miRNAs DBF4 PCNA SMC3 SMAD4 ORC1L MYT1 PLK1 ORC3 SKP2 CDK7 E2F4 CDC45 CDK2 MDM2 PMC8294037__F2 Functional Polymorphisms in the p53 Pathway Genes on the Genetic Susceptibility to Zika Virus Teratogenesis TG LIF GC MDM2 PMC4382528__F2 Metabolic pathway of rotigotine UGT1A9 UGT2B15 CYP2C19 CYP1A1 CYP3A4 PMC5630306__F7 Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL-5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL MBP IL5RA LYN IL5 PMC3238353__F2 Crosstalk between UPR signalling pathways and lipogenesis NR1C1 APOB ATF4 EIF2A INSIG1 PMC7941261__F5 Skeletogenic cell gene regulatory network (GRN) HEL23 FOXN2 ERG TEF PMC3238353__F1 ER stress and activation of the UPR signalling pathways ELF2 ATF4 PMC10388482__F9 SALL4 promotes angiogenesis in gastric cancer by regulating VEGF expression and targeting SALL4/VEGF pathway inhibits cancer progression VEGFB VEGFC VEGFA PMC3681689__F6 Working model for the roles of the mitochondrial chaperones Ssq1-Jac1 and the glutaredoxin Grx5 in Fe/S protein maturation in eukaryotes NFU1 PMC6123662__F2 Brown adipocyte glucose metabolism: a heated subject HMFN0839 AQP3 GYS2 HK2 FASN UCP1 ACD CS MPC1 HEL-S-30 PCK1 GPD1 ADRB3 TG ACSL1 AQP7 DGAT2 AQP9 GYS1 PC PMC3644409__F7 Proposed model showing molecular mechanisms of dysregulated immune pathways in diabetic renal tissues STAT3 MSRA SELE BMP7 SIGIRR IL4 GPX3 TRAF6 CXCL14 IL6R UCP2 TSLP HLA-E BCL10 TLR4 HEL-S-162eP TAP2 MIP HEL-S-64p CEBPB HLA-A PMC5369916__F4 Summary of detected genes associated with the MTX toxicity in RA patients in previous studies RFC1 ABCC1 AMPD1 DHFR SLC46A1 MTRR TYMS HEL-S-70p SLC16A7 GGH ABCG2 ABCC2 CCND1 FPGS ABCB1 ADA PMC2786873__F9 Model of amino acid starvation-induced AARE-dependent transcription in human cells CDC42 ATF3 ATF4 ATF2 EIF2A RAC1 PMC7157599__F2 An overview of intracellular signaling pathway regulation by the HECT E3 ubiquitin ligases WWP1 HERC1 UBR5 SMURF1 HERC4 NEDD4 ITCH PTEN SMURF2 MYC HUWE1 PMC8350904__EV4 Schematic depiction of the metabolic networks active during latent HIV‐1 infection in microglial cells ACLY HEL107 FH H6PD LDHAL6A PCK1 PGAM4 SDHA HEL-S-304 RPIA HEL-S-68p HEL-S-162eP FBP1 HEL-S-32 ENO1 GCK HEL-S-87p PKLR PMC7953519__F7 Novel compound variants of the AR and MAP3K1 genes are related to the clinical heterogeneity of androgen insensitivity syndrome MAP3K1 SOX9 CTNNB1 PMC2719801__F3 Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways PIK3CA MAP4K3 SLC2A4 PIK3R3 PTPN11 MAPK8 MAP3K2 HEL-S-42 INSR RPS6KB1 SOS2 PRKAA2 MAP3K7 TBC1D4 PMC2719801__F2 Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways HEL-S-31 PIK3CA RAF1 VAMP2 SLC2A4 PIK3CD PIK3R1 SOCS3 MAPK8 MINK1 MAPK4 INSR CBLC PDPK1 PRKCA MAPK12 PTPN11 EIF4E RHEB PRKCQ GYS1 RAPGEF1 IKBKB LIPE PFKL EHD1 PMC7600158__F1 MicroRNA (miRNA)-mediated modulating response to gemcitabine STAT3 NDRG2 APC LIF GSK3B PTEN NF2 SRC CTNNB1 PMC12237979__F2 Necroptotic pathways RIPK3 FAS ZBP1 TRADD TLR3 MLKL TLR4 TRAF2 FADD PMC2517664__F2 A simplified diagram of the key type-1 cytokine/receptor interactions relevant for immunity against intracellular bacteria, derived from published gene knockout mouse studies IFNG IFNGR2 IFNGR1 IL12RB1 PMC6345051__F5 Visual representation of molecular interactions in the TSF flock MDK TGFBI CADM1 BOC BANK1 FAM3B NID1 NID2 TEAD3 tmp_locus_29 SYNM NGB COL4A2 COL4A1 PRELP DCN RBM38 OAF COL14A1 LINGO1 PARM1 SLC22A17 ISL2 GRB14 P3H2 PMC3410677__F9 Schematic representation of potential interaction between the Rho GTPase signaling pathway, CTGF, and NMU in regulation of actomyosin-based contractile force and ECM protein profiles in TM cells NMU ARHA RHO PMC6345051__F4 Visual representation of molecular interactions in the HSF flock LTB FCMR CD79B CD79A CCL22 CCL19 CXCL13 FCER2 JCHAIN CD22 CR2 CD19 PMC3798767__F5 p53 regulated developmental pathways TPR CRK MAP3K7IP1 MAK APC MAPKAPK2 SMAD4 NUMB APP GRB2 SFRP1 WIF1 PMC9097798__F1 Development of novel agents for the treatment of early estrogen receptor positive breast cancer EGF EGFR MTOR PMC2679052__F7 Diagram summarizing differences in expression of interaction genes enriched within the KEGG p53 signaling pathway, and possible interactions of corresponding proteins with the androgen receptor CDKN1A PTEN CCND1 PMC4298213__F1 Generalized central metabolic pathway adapted and modified from a previous study SDHD GOT2 HEL-S-304 HEXA PC TREH HEL-S-32 MDH2 PMC5359264__F3 ReactomeFIViz: from disease pathway to PPI network ERF UBC SP1 TFDP1 E2F2 E2F3 PMC7553876__F1 Hypothetical mechanism by which SARS-CoV-2 successfully evade the immune system while maintaining an inflammatory feedback loop TMPRSS2 ADAM17 CCL3 ACE2 IL1B PMC9546682__F7 Yangxin Tongmai Decoction in the Treatment of Coronary Heart Disease with Blood Stasis Syndrome Based on Network Pharmacology and Molecular Docking SYK MYB COMP GAL BAD ASIP APP PTEN GRB2 MTOR MYC PMC10931763__F8 “Component–gene–pathway” network STAT3 PPARG HPSE PIK3CA EGFR IGF1R TERT HTR2A HTR2B RB1 BCL2L1 DRD1 DRD2 FGFR1 IL2 PDE4D CSF1R NR1i1 JUN ITGA4 PLG TRPV1 NTRK2 PTGS2 MMP9 VEGFA NR3C1 S1PR1 NR1C1 ADRB2 CASP3 NTRK1 PMC9942259__F7 LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/B‑catenin pathway CDH2 LAPTM5 MMP2 FOXP3 MMP9 CCND1 PMC8105340__F9 Endovascular progenitors cell fate SOX9 PDGFRA PTCH1 HES1 RBPJ CD34 PMC8102455__F2 Fabry Disease: The Current Treatment Landscape HEXA GLA GLB1 A4GALT PMC4367559__F2 Mechanisms of resistance due to MET/HGF pathway and potential interventional strategies EGF HGF EGFR VEGFA PMC6162868__F1 Signaling pathways of high-risk HPV oncogenes MDM2 CCND1 CDK4 PMC4367559__F1 MET/HGF signaling and functional cross-talk with other pathways EGF BAD HGF ALK EGFR GRB2 MTOR VEGFA SHE SRC CTNNB1 PMC8955100__F1 Expression Profile and Biological Role of Immune Checkpoints in Disease Progression of HIV/SIV Infection ZAP70 CD48 TIGIT CD160 BTLA LAG3 LCK PMC11241432__F3 MyD88-independent signaling pathway MAP3K7IP1 TAB3 MAL IRAK1 TRAF6 IRAK4 MYD88 PMC5693225__F6 RPL23 links oncogenic RAS signaling to p53-mediated tumor suppression MDM2 MTOR RPL23 PMC5779689__F2 Convergence of miR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells TCP1 PCNA HEL-S-100n RBBP7 HEL-S-99n GLUD1 EZR HEL-S-128m HSPD1 EIF4A1 SGTA HEL-S-44 PA2G4 RPSA RANBP1 ANXA2 ANXA1 HEL-S-94n PROX2 HEL-S-47e HEL-S-49 LAP3 RUVBL2 ENO1 YWHAZ PMC6154708__F5 Epigenetic mechanisms of nanotopography-guided osteogenic differentiation of mesenchymal stem cells via high-throughput transcriptome sequencing KLK4 GNRH1 SMAD2 DYSF CD99 MMP11 NLRP3 TMEPAI HRC PI3 HAL DPT CGB3 LAT2 MEFV FSTL3 TPSG1 CTRC ALAS2 TNLG2B AQP6 MAP1LC3C JPH2 TRPM2 CMYA5 PRSS16 IGF1 AQP7 MT1B AQP1 PMC5730046__F3 Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming HEL107 FH HK3 ME1 PRKAA1 RPE PGAM2 RPIA HEL-S-68p OGDH SLC2A13 HEL-S-49 HEL-S-162eP PC MDH2 GCK PKLR PMC6086774__F1 Lipid metabolism in tumor cells ACLY TG ACSL1 CD36 FASN HEL-S-5 PMC6029376__F7 Working model of the mechanistic interaction of miR-335-5p and CPNE1 in the control of the EGFR signaling pathway: miR-335-5p regulates CPNE1 expression via EGFR signaling in NSCLC CDH2 EGF CPNE1 MMP9 SRC CCND1 PMC7139634__F6 Most common target genes and mTOR pathway regulated by the differentially expressed exosomal miRNAs IGF1 INSR PXN EIF4EBP1 PDPK1 PTEN MTOR PMC7913176__F4 Degree Adjusted Large-Scale Network Analysis Reveals Novel Putative Metabolic Disease Genes GFER RAF1 AXL EGFR COPS5 DTL RANBP9 OPRM1 NR3C1 TGFBR1 MAEA FABP5 CENPW APP TOP2A YWHAZ PMC7465132__F2 Cell death receptor-associated signaling pathway TRADD MLKL CYLD TRAF2 FADD PMC7795579__F1 Inflammation-Induced Protein Unfolding in Airway Smooth Muscle Triggers a Homeostatic Response in Mitochondria MAX MFN2 MCU PMC7984080__F1 Brain death‐induced lung injury is complement dependent, with a primary role for the classical/lectin pathway C6 C7 C9 PMC3281591__F4 Mitochondrial-dependent apoptosis CASP9 BCL2 PMC6961632__F1 Unique Features of Nodules.(A) Nod factor activation of the CSSP TF FEN1 ERN2 MNT DCT SST PMC5653517__F1 Resistance to BRAF inhibitors can occur through stromal extracellular signals (blue) leading to ERK reactivation upstream of MEK (orange) or to enhanced survival signaling(green) ERBB3 NF1 EGFR BRAF IGF1R PMC8784536__F2 Immunomodulatory effects and mechanisms of distraction osteogenesis SMAD4 PMC7710763__F1 Interaction between gut microbiota, immune system and tryptophan metabolism in brain tumor development EGF STAT1 IL10 IDO1 AHR IL2 SLC1A4 SLC7A11 ATF4 IL6 IL1B PMC5390343__F6 Regulation of Fn expression in macrophages after S CD14 SRC TRAF6 MYD88 PMC2886982__F3 Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes HEL-S-31 LPL FAS CIDEA PMC8584042__F2 Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface LATS1 PIEZO1 LATS2 RHO SRC PMC9485670__F2 Advances in the research of the mechanism of secondary resistance to imatinib in gastrointestinal stromal tumors IGF1R MDM2 PMC7679160__F8 PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion TBK1 MAVS PPM1G IRF3 PMC8037620__F1 Spectrum of changes in a senescent cell FAS CSF1 MMP12 IGFBP4 IGFBP2 CCL5 MTOR CCL2 CSF3 IFNG INHBA CCL7 MMP3 HMGB1 CSF2 IRF1 CXCL2 MMP9 VEGFA IL1A TNF PARP1 DIPLA1 NFKB1 CDK2 SERPINB2 VCAM1 GATA4 CCL8 PMC4217731__F7 Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice NR1C1 COX4I1 PPARGC1A CPT1A PMC6487791__F3 Therapeutic strategies targeting mutant p53 CDC2 BAX ATR USP15 CDKN1A WEE1 ATM MDM2 PMC6487791__F2 Representative working modes of mutant p53 GOF TXN SMAD2 SLC7A11 ARHA PIN1 CDK4 PMC5915168__F1 MIF signaling pathway and its role in tumorigenesis CD44 CD74 MIF SRC PMC5514692__F7 Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption HMOX1 BACH1 HEPH PMC2840235__F1 Blockade of the VEGF pathway with mAbs VEGFB VEGFC PIGF VEGFA PMC12108901__F7 Comprehensive model of nitrogen and phosphorus interaction at different levels IMP3 DAO PMC5053787__F1 Complement cascade HEL-S-62p C1S C1R C4B_2 PMC9658871__F8 Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D POSTN HEL113 PLD2 PMC4648367__F7 Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway targetgenes and promote cell migration LATS1 LPA EGF NRG1 ANKRD1 ERBB4 EGFR PMC7783759__F7 Cezanne deubiquitinated IGF-1R and regulated IGF-1R signaling pathways IGF1 IGF1R ATF2 IRS1 PMC9368778__F5 Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant LATS1 TBK1 LATS2 CGAS IRF3 PMC2807212__F3 TGFB superfamily and FGF signaling pathways FRS2 SMAD6 SMAD4 GRB2 PMC10255413__F2 Biosynthetic pathway of chlorophyll POR CPOX MGP PMC8536449__F9 GNG4 Promotes Tumor Progression in Colorectal Cancer PLEK GAL BAD CELA1 PI3 CD19 MTOR MYC PMC2807212__F2 Hh and Wnt signaling pathways SUFU APC PTCH1 SMO CTNNB1 PMC8507869__F3 Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring ROS1 AXL EGFR BRAF PTEN MTOR KRAS RB1 ALK CCNE1 CCND2 NTRK1 CCND1 RET CDK4 PMC9268608__F11 Stereoselective Binding of Trans-(±)-Kusunokinin and Cis-(±)-Kusunokinin Isomers to CSF1R STAT3 EGF CSF1 COX2 IL34 EGFR JAK3 CDK2 CCND1 AKR1B1 CSF1R PMC3514894__F1 Interplay between Smoking-induced Genotoxicity and Altered Signaling in Pancreatic Carcinogenesis CDH2 STAT3 EGF JUN EGFR CDH24 MMP9 MYC KRAS FOS GC BCL2 PAH PMC5292191__F2 Extrinsic and intrinsic pathways of apoptosis BAX FAS FADD PMC5292191__F1 TGFB signaling pathways SPARC GIP ARHA RHO GRB2 SHE SRC RAC1 PMC4572424__F2 Effect of purple corn anthocyanins (PCA) on CCN2 expression STAT3 STAT1 SMAD4 CTGF PMC4156078__F7 Schematic diagram depicting the proposed role of miR-130a in BMP-SMAD signaling and hepcidin regulation under iron-deficient conditions BMP6 SMAD1 DKFZp781O1323 SMAD4 HFE2 PMC8123809__F1 Effect of Space Travel on Bone Metabolism: Considerations on Today’s Major Challenges and Advances in Pharmacology BMP4 BMP2 RUNX2 CTNNB1 PMC9631428__F1 Research progress on microRNA in gout EPHA2 NLRP3 ZEB2 TRAF6 IRAK4 MYD88 PMC5684415__F1 Highest confidence network of genes significantly dysregulated by miR-7 AURKA NCEH1 TRIP13 KIF11 CDC20 NCAPG RRM2 SMAD6 KIF23 FOXM1 CDCA8 CCNB1 ATL1 PMC5824027__F3 Hippo Pathway in Cancer Stem Cell Biology LATS1 LATS2 APC RHO SRC VGLL4 PMC5078657__F2 Cancer pathway targets affected by curcumin ERCC1 STAT3 BAX EGR1 EGFR MTOR VEGFA PTCH1 SHH CDC27 ABCG2 CXCR4 CCNB1 CCND1 PMC3650722__F3 Network was generated using Ingenuity Pathway Analysis (Ingenuity Systems, www.ingenuity.com) LIPA APOC3 PDGFD SORT1 PMC9587083__F7 Hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer ADAM2 CD44 IDUA GUSB HMMR WWOX HAS3 HAS2 HYAL2 HYAL3 VCAN HYAL4 PMC5824027__F1 Hippo Pathway in Cancer Stem Cell Biology LATS1 LATS2 DKK1 AREG VGLL4 PMC4660682__F5 Relative functions and pathways in DN CRP APOA2 EGF TXN CSF1 LEP LGALS3BP CD9 KLK3 HAMP IL6ST PMC5039640__F6 Unravelling molecular mechanisms from floral initiation to lipid biosynthesis in a promising biofuel tree species, Pongamia pinnata using transcriptome analysis LPA HEL-S-5 ACD PMC3193279__F1 VEGF Signaling Pathway within endothelial cells TIMP3 RAF1 FRS2 SOS1 PTPN1 ITGAV FGF2 CRK VEGFB PIGF CSK FLT1 KDR GRB2 PMC10367548__F8 The mechanism by purinergic receptor P2Y12 drives ConA-mediated autoimmune hepatitis through hexokinase 2-dependent glycolysis pathway IFNG HK2 PMC6889474__F3 mTOR Signaling Pathway RHEB EEF2K TSC2 EIF4B TSC1 SGK1 PTEN MCRS1 EIF4E PMC6729444__F7 p35/Cdk5 involvement in RasGRF2 signaling EGF EGFR RASGRF2 PMC5037594__F7 Signaling pathways in EGF-induced AREG mRNA expression EGF EGFR AREG PMC3722917__F3 Naive CD8+ T cells differentiate into cytotoxic T lymphocytes (CTLs) on exposure to antigens TH TRO APC PMC11040418__F2 Network pharmacological analysis of chondrocyte apoptosis modulation by RJNTF AURKA FUS PXN COPS5 SMAD2 GSK3B HIF1A MYC TRAF6 CCL2 PIN1 FLNA RPS8 RPA3 RPL10 MDM2 SRC HDAC2 MAPK1 NOS2 IRF1 EZH2 ILF3 TNF TUBB CXCL10 CAND1 RNF2 NEDD8 CUL4A BAG3 MAP3K1 CUL7 HSPA4 MCM5 CDK2 SNW1 MCM2 VCAM1 GRB2 SIRT1 NCL EGFR IKBKE HEL-S-310 VCP U2AF2 RPS3 TUB APP CLTC CDC5L HEL2 IL1B HDAC6 HEL-S-72p EWSR1 UBC JUN ARRB2 ITGA4 RPS2 SELE RPS27A CXCL2 PTGS2 IL6 PABPC1 RPA1 PARP1 VHL NFKB1 RELA HEL-S-102 NTRK1 NFKBIA EP300 PS1TP5BP1 YWHAZ PMC8209426__F10 An Integrated Analysis of the Response of Colorectal Adenocarcinoma Caco-2 Cells to X-Ray Exposure FOXM1 WEE1 ATM MYT1 PMC7584388__F5 Mechanisms underlying T cell ageing ZAP70 CGAS MAP3K7IP1 LAT MTOR GATA4 PMC8428233__F2 Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid Tumors STAT3 BAX STAT1 CD24 SMAD2 SMAD4 JAK1 MYC RUNX2 PMC7906381__F2 Pathway enrichment analysis of (a) DE-miRNAs and (b) DCGs RALA KIT MTOR PMC9593040__F2 Mitophagy in the aging nervous system GABARAP PINK1 PMC3337681__F7 Putative inhibitory pathway of inflammatory signaling events by CA SYK TLR4 IRAK1 ATF2 SRC PMC11939404__F9 Proposed mechanism of action of GAD037 INSR BOC ACTN4 PMC9025382__F6 RNA-Seq of Cyst Nematode Infestation of Potato (Solanum tuberosum L.): A Comparative Transcriptome Analysis of Resistant and Susceptible Cultivars MYB ERF FER PMC8340210__F2 Development of PARP inhibitor combinations for castration resistant prostate cancer unselected for homologous recombination repair mutations FOXA1 PARP2 PMC11013310__F6 Our results are summarized in this diagram HGF IGF1 PCNA CTNNB1 PMC2390572__F9 MCF10A Pathway 1 affected by TFIIS knockdown IL15 HMGN2 CTSW PERP TLE4 IFIT3 MYC BAMBI RBBP7 PPP1R15A NPDC1 NKX2-8 GPRC5A ARID4A SS18 TNPO2 PMC2390572__F8 Major pathways affected by TFIIS knockdown in MCF7 RPL35 CFHR4 RPS23 RPL18 DKFZp667O1614 NRP2 IRAK1 RPL21 RPL23 MYC KITLG CDKN2A SERPINB5 SMARCC2 GTF2B BLZF1 CFI PLXNA3 RPL27 RPL41 FGFR3 HEL-S-32 BRD2 SMARCA4 PMC5325772__F4 Summary of relationship between B-catenin, MEN1, and NCOR1 mutations and the Wnt signaling pathway that upregulates aerobic glycosylation NCOR1 MEN1 CTNNB1 PMC8303858__F4 Bioinformatics Analysis of Allele Frequencies and Expression Patterns of ACE2, TMPRSS2 and FURIN in Different Populations and Susceptibility to SARS-CoV-2 TMPRSS2 TGFBI SLC2A4 HIF1A MMP9 VEGFA FURIN INS IFNG REN EDN1 APLN MMP2 ADAM10 NPPB ACE2 FGF23 PMC3765220__F4 Pathway Studio analysis of the differentially expressed proteins of extremely severe HFMD serum samples. Proteins identified in Table  were imported into PathwayAssist and an interaction map was created ITIH2 KRT1 FCN3 RPE65 PML RBP4 RDH11 HEL-S-92n BRCA1 HEL-S-2a RDH5 A2M HP PMC7349719__F2 GH/IGF on the Aging Mitochondria IGF1 BNIP3 IGF1R CS BNIP3L GHR PMC3046063__F7 Proposed working model and protein–protein interaction map KIF15 GNAI3 EGFR PTEN CENPE MTOR NDEL1 ATG3 PI3 ATG5 MAPK1 GNAI1 NBR1 BAX MAP1B UVRAG PARP1 XRCC3 ATG10 TSC2 WDFY3 BCL2 INSC BAK1 DISC1 PMC5963164__F7 Prostate cancer pathway enriched in KEGG HEL-S-22 BAD FRK CDK2 BCL2 PTEN MDM2 MTOR PMC5963164__F8 ERK/MAPK signaling enriched in IPA ARAF CRK BAD FYN MOS PXN PC ATF1 GRB2 SRC DOCK1 EIF4E PMC7349719__F6 GH/IGF on the Aging Mitochondria BAD IGF1 BCL2 BMF IGF1R HRK BIK PMC12256062__F8 Antagonists of cGAS-STING pathway for liver diseases therapy TBK1 CGAS NLRP3 IRF3 XBP1 PMC6581679__F1 Canonical activation of HH-GLI signaling SUFU GSK3B SMO GLI3 PMC6409748__F2 TLR-7/-8 signaling in dendritic cells IRAK1 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC6581679__F3 Non-canonical activation of HH-GLI signaling by oncogenic pathways BRD4 DYRK2 DYRK1A SOX9 EGFR GSK3B DYRK1B NUMB MTOR PMC1087583__F5 The secretory pathway and UPR under different conditions SEC63 VPS41 PMC3502714__F3 Fibroblast growth factor 23: State of the field and future directions GALNT3 FGFR4 FURIN FGF23 PMC3502714__F2 Fibroblast growth factor 23: State of the field and future directions GALNT3 NHERF1 FGFR1 PTH FURIN FGF23 PMC9477627__F8 Identification of Molecular Targets and Underlying Mechanisms of Xiaoji Recipe against Pancreatic Cancer Based on Network Pharmacology MAX CAP2 TH MYB FAS GRB2 MYC TNF SKI FLNA RAC1 PMC8340210__F1 Development of PARP inhibitor combinations for castration resistant prostate cancer unselected for homologous recombination repair mutations BRIP1 ATR BRCA2 FANCL SSB PARP1 BARD1 RAD51C CDK12 BRCA1 CHEK2 CHEK1 ATM PALB2 PMC10530558__F6 Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells HEL-S-5 PMC10530558__F2 Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells HEL-S-133P HK2 MYC KRAS PMC10530558__F1 Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells HIF1A MYC KRAS PMC6215910__F7 Model illustrating the potential pathway from pseudohypoxia-induced cilia loss to increased cell proliferation and dysregulation of tumorigenesis relevant cilia-mediated signaling pathways in PCCs FH VHL HDAC6 PMC2564980__F5 Genes with differential expression in the carcinoma and papillary adenocarcinoma tumors were assembled into distinct metabolic pathways CDC42 ATR SMAD1 THBS1 EGFR APC AKT3 GSK3B FZD9 SMAD4 TCF4 RHO LAMC1 PSEN1 CTNNB1 FZD8 INHBA CCND2 FST SRC GBP2 PMC2564980__F7 Higher expression of genes involved in O-glycan synthesis in the carcinoma compared to the papillary adenocarcinoma tumors GALNT10 GALNT7 PMC8556325__F1 KRAS pathway and targeted preclinical and clinical agents EGFR GRB2 MTOR PMC6021495__F10 Working model proposed for the synergistic action of GH and insulin on IGF-I and -II expression in the carp liver INSR MTOR GHR PMC5795449__F4 IDO1-mediated Tryptophan Depletion IFNG IFNGR2 IFNGR1 PMC9576517__F2 Mouse models of nonalcoholic fatty liver disease (NAFLD): pathomechanisms and pharmacotherapies TBK1 CXCR6 TGFA FOXO1 PER1 FASN HEL-S-7 HEL-S-5 ELF2 FOXA3 CCL2 MERTK PMC9313121__F4 Differential Neuropathology, Genetics, and Transcriptomics in Two Kindred Cases with Alzheimer’s Disease and Lewy Body Dementia SNAP25 PMC8944741__F7 Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases ACHE BAX LPO BACE1 BCHE BDNF IL1B PMC9377080__F2 Diverse functions of FAT1 in cancer progression: good, bad, or ugly? NRG2 EGF NRG1 HBEGF EGFR LRP5 FAT1 LRP6 MTOR YAP1 IRS1 PMC9052917__F7 Complement dysregulation is associated with severe COVID-19 illness CRP C2 CFH CS PMC8108610__F1 Entry, egress and vertical transmission of SARS-CoV-2 TMPRSS2 HEL-S-69p ACE2 PMC4809647__F3 Highly heterogeneous, activated and short-lived regulatory T cells during chronic filarial infection IL10 LAT CCL4 ARAP2 CTLA4 PMC6761256__F10 Putative mechanism of necroptosis and relative inflammatory responses during the development of CCI HMGB1 NLRP3 TNFAIP3 MLKL IL1B PMC12112630__F17 Overexpression of miR-454-3p leads to the inhibition of STAT3 and ATG12, which are involved in molecular pathways promoting Chondrosarcoma cell proliferation and evasion of apoptotic and autophagic mechanisms STAT3 ATG10 ATG12 ATG5 PMC9681860__F1 Copper homeostasis and cuproptosis in health and disease ATOX1 CCS SCO1 ATP7B COX17 COX11 SLC31A1 HEL-S-44 ATP7A PMC9681860__F2 Copper homeostasis and cuproptosis in health and disease DLAT LIAS FES FDX1 PMC2673236__F1 Schematic illustration of one-carbon metabolism pathway MTRR HEL-S-61p MTR PMC6681663__F1 Everolimus for the treatment of advanced pancreatic ductal adenocarcinoma (PDAC) RHEB ELF4 RICTOR PTEN MTOR PMC6394863__F6 Fluid forces shape the embryonic heart: insights from zebrafish HEG1 NRG1 WWTR1 ERBB2 WNT9B PMC6934083__F1 Autophagy regulates the expression of HDAC proteins which in turn leads to altered transcription and enhanced tumor cell immunogenicity IDO1 MTOR EIF2A ATG5 PMC10136927__F3 Targeting Wnt signaling pathway by the latest technologies RNF43 APC FZD7 LRP5 ZNRF3 PTK7 LRP6 GPR49 CTNNB1 PMC11667779__F3 Adenosine signaling in TAMs ARG1 PMC3843886__F2 Schematic of common signalling pathways underlying activity-dependent and leptin-dependent synaptic plasticity STAT3 GSK3B PMC6850109__F1 Pathogenesis of antibody‐mediated rejection and potential therapeutic targets CD40 IDE CP PMC7921060__F6 BMP/Hippo signaling modulating VEGFR pathway and angiogenic phenotype of endothelial cells BMP6 SNAI2 DLL4 BMP2 AREG PMC5059634__F3 Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes GAA CS PMC3967813__F2 IFNAlpha-2b signaling via JAK-STAT pathway, adapted from IFNAR2 CRKL JAK1 TYK2 PMC3151145__F1 Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling NPC2 ABCG1 ACAT1 NPC1 HMGCR CD36 TLR4 CD14 LDLR PMC8508945__F2 Translation Initiation Machinery as a Tumor Selective Target for Radiosensitization TSC2 TSC1 PTEN EIF4E PMC6657652__F6 Antibactericidal mechanisms of C5a-TLR2 cross-talk induced by P TIRAP ARHA MYD88 PMC3854412__F7 SIRT1 negatively regulates amyloid-beta-induced inflammation via the NFKB pathway RPE IL6 SIRT1 PMC5037286__F2 The NLRP3 inflammasome by the ubiquitin system SHARPIN NLRP3 TLR4 TRAF2 BRCC3 PMC5378051__F3 Homologous mammalian and fungal host-defense pathways that signal through prion conversion NWD2 NLRP3 PMC6657652__F2 Contrast inflammatory signals in human gingival fibroblasts triggered by the different acylation structures of P TLR4 CD14 LBP PMC6314538__F3 Cell cycle timing and regulation of replicative histone genes NASP SLBP NPAT TBP TUT7 MYC PMC5661375__F2 Function of TGFB1 in normal lung and lung cancer cell responses to radiotherapy SMAD2 SMAD4 PMC5661375__F1 TGFB1 signaling pathway SMAD2 SMAD4 PMC4424078__F1 Viral Activation of Cellular Metabolism HK2 FASN PMC6524506__F1 Hydrogen peroxide mediates pro-inflammatory cell-to-cell signaling: a new therapeutic target for inflammation? LOX PI3 TLR4 IL1B PMC5721733__F8 Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway SIRT3 NLRP3 PMC6721535__F1 The catecholamine biosynthetic pathway in an adrenomedullary chromaffin cell or a pheochromocytoma cell VIT TH LAT PNMT DBH PMC6387316__F3 Pathways controlling the response of physioxia MSC chondrogenesis ACAN ADAMTS4 SOX9 FOXO1 FOXO3A COL10A1 RUNX2 COL2A1 PMC7109575__F1 Role of the Wnt/Beta-catenin signaling pathway in chemoresistance of colorectal cancer MMP7 FAS APC GSK3B CTNNB1 PMC8345981__F1 TGF-Beta as a Master Regulator of Diabetic Nephropathy COL1A2 SMAD2 COL4A2 SMAD4 COL4A1 TGFBR1 PMC11688252__F2 Key signaling events underlying D-lactate-induced metabolic reprogramming in bFLS HEL-S-133P HIF1A PMC6930194__F1 Schematic illustrating interaction of key elements in the tumor stroma in CCA progression PDGFD VEGFC CXCL1 MSC HIF1A IL6 VEGFA CCL2 PMC10688450__F4 Link between U2AF1 and NFKB signalling in MDS and AML SF3B1 CASP8 U2AF1 MAP3K7 IRAK4 MYD88 PMC8592571__F8 Proposed cold-induced vasoconstriction signalling pathway in young and aged mice TRPA1 TRPM8 PMC6160385__F5 Βeta-TRCP in regulating the Wnt signaling CD44 TCF3 APC LRP5 ZNRF3 LRP6 SKP1 MYC GPR49 LEF1 CTNNB1 PMC8533541__F2 Bioactive Scaffolds Integrated with Liposomal or Extracellular Vesicles for Bone Regeneration CDC2 BMPR2 BAX CDK2 PMC5713305__F2 Nuclear factor erythroid 2-related factor 2 (Nrf2) regulatory pathway HMOX1 KEAP1 GCLM GCLC RXRA MAF FECH PMC3384412__F2 UPR signaling in diseases ATF4 EIF2A XBP1 PMC1327682__F3 Schematic overview of the Saccharomyces cerevisiae central carbon metabolism HEL60 GPD2 ENO2 HEL-S-62p MAL ENO1 CIT PMC4853753__F5 Cerebellum Development and Tumorigenesis: a p53-centric Perspective ATOH1 PTCH1 SHH SMO CCND1 RORA PMC6465609__F8 Schematic model of DHAV-1 inhibiting type I interferon signaling by hijacking the SOCS3 protein IFNG STAT3 STAT1 TLR3 OASL IRF3 MX1 SOCS3 PMC9205118__F8 Identification of the key flavonoid and lipid synthesis proteins in the pulp of two sea buckthorn cultivars at different developmental stages LPA POLL DGAT1 PC POLI PMC11878485__F1 The role of signaling pathways in the mechanisms of glaucoma in retinal ganglion cells apoptosis, optical nerve protection and regeneration, and the LC damage and remodeling PTEN RHO BDNF PMC10137309__F3 Extravasation steps in lung cancer brain metastasis ADAM9 RHO AKR1B10 CCL2 PMC10137309__F2 Extravasation steps in melanoma brain metastasis CXCR3 S100A4 PLG MMP2 CCR4 PLEKHA5 MMP9 PMC11878485__F2 Review of glaucoma related signaling pathways and their mechanisms BAX BAD TRADD PLG PTEN ARHA BDNF TNF TRAF2 PMC4192461__F11 Proposed schematic for the maturation of mNT and its role in exporting mitochondrial Fe-S and reactivating the cytosolic apo-IRP1 into Fe-S aconitase after H2O2-induced oxidative and nitrosative stress NUBP1 CIAPIN1 FXN ISCU MNT PMC11878485__F4 The Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 CCND1 CTNNB1 PMC7641192__F3 Calcium signalling pathway (map04020) obtained from KEGG database with official permission and guidance from Kanehisha Laboratories (permission ref 200,290) PLN CAV3 BCR MCU PMC10137309__F1 Extravasation steps in breast cancer brain metastasis SEMA4D CD44 HPSE CD24 HBEGF COX2 MUC1 ADAM8 GBP1 MMP9 CXCR4 PMC4388007__F4 Significantly affected canonical pathway “interferon signaling”, as determined by IPA® analysis SOCS1 BAX PSMB8 IRF9 IFIT3 IRF1 IFI35 IFNG PIAS1 BCL2 MX1 JAK1 OAS1 TYK2 PMC6365940__F9 Pathway involved in gemcitabine-resistant pancreatic cancer cells with digoxin treatment KEAP1 NQO1 GCLC MAF ABCC5 PMC8264328__F1 One carbon metabolism in human lung cancer MTHFD2 MTHFD1 TYMS HEL-S-51e PMC4659372__F1 PD-1 signaling in effector T cells CD80 HDAC9 HDAC7 FOXP3 SKP2 SIRT1 HDAC6 PMC3385961__F1 Evolution of Wnt pathways APC GSK3B RYK RHO SRC CTNNB1 PMC3031560__F5 Identification of Novel Molecular Targets for Endometrial Cancer Using a Drill-Down LC-MS/MS Approach with iTRAQ APOA2 AHSG SFRP4 APOH DBI FGA HNRNPK HEL-S-78p PMC8551152__F6 Schematic diagram CHI3L1 CD44 TGFB1 TIMP1 E2F4 ZDHHC19 HIF1A HEL-S-26 PMC3973207__F8 Schematic diagram showing differences in the thyroid cancer cell lines sensitive or resistant to apoptosis BAX BAD PMC4918620__F4 MAPK signaling pathway (orange nodes are associated with upregulated or only whole dataset genes and green nodes have no significance) MAX NGF FAS CD14 ATF2 DAO FLNA TRAF2 MEF2C PMC3518257__F7 14-3-3 signaling canonical pathway from IPA BAX BAD CBL GFAP AIP GRB2 PMC4867619__F3 IPA analysis: (Panel a) Top Network Cell Death and Survival, Inflammatory Response, Cancer MMP12 HSPB2-C11orf52 TLR3 MUC5B CD40LG SMPD1 FGF2 PMC4405237__F1 Diversification of importinA isoforms in cellular trafficking and disease states RAN RANBP1 PMC7698114__F2 Difference of two variants of CDK20 SNAPIN CDK2 CDK20 CCNH PMC4483546__F1 Metformin on hepatocyte energy status and the mammalian target of rapamycin pathway, in turn affecting metabolism and inflammation RHEB EGF TSC2 TSC1 PTEN MTOR DEPTOR EIF4E PMC9573519__F2 Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets UCP2 BAX FAS FADD PMC9573519__F1 Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets TLR9 EN1 HEL-S-28 MMP9 MTOR IL1B PMC8069505__F3 Important molecular mechanisms by which AEG-1 induces chemoresistance ALDH3A1 DPYD MTOR ATG5 ABCB1 PMC9194098__F2 Traditional Chinese Medicine in Bone Regeneration and Osteoporosis SEMA3A GSK3B NRP1 BMP2 CTNNB1 PMC10812436__F3 Main anti-inflammatory properties of HDLs VCAM1 CCL2 TNF PMC8348456__F1 Inflammatory Response in COVID-19 Patients Resulting from the Interaction of the Inflammasome and SARS-CoV-2 TMPRSS2 GSDMD NLRP3 ACE2 IL1B PMC9360520__F1 Deciphering the myth of icariin and synthetic derivatives in improving erectile function from a molecular biology perspective: a narrative review SMAD2 SMAD4 PMC11600669__F1 Signaling pathway according to KEGG (A) NAFLD and (B) PPAR LPL CAST HEL-S-28 PMC7803009__F1 Congenital Malformations in Pregnancies with Pre-existing Diabetes DNMT3B PAX3 PMC10494486__F7 Signaling model for late-phase IP-10 induction by MRP8/14 in endotoxic mice CXCR3 STAT1 TLR4 IRF7 JAK1 TYK2 PMC6161739__F5 Current model of NLRP3 subcellular localization during its activation process.Notes: Primed NLRP3 is both cytosolic and associated with endoplasmic reticulum (eR) GSDMD MAVS NLRP3 MFN2 MARK4 PMC2603035__F3 Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease TGFB1 BMP2 PAH PMC8875910__F1 Multifaceted Roles of Mast Cells in Immune Homeostasis, Infections and Cancers SYK BTK RAF1 TIRAP LYN MYD88 PMC7092503__F7 Differentially expressed interactors of APE1 in colorectal cancer MPG ETFB CLIC1 IDH3B RPS14 DBT SLC25A3 HEL-S-51e TXN HSPD1 HEL-S-29 MUTYH HEL-S-26 TOMM40 ACOT7 ECHS1 HSD17B10 TRNT1 ILF3 DUT UQCRC1 SDHB PDHA1 LIG1 BCAP31 OGDH LAP3 NADK2 SIRT1 TUFM CNP TIMM44 ALDH2 ETFA RPS3 UQCRC2 CLIC4 FH FEN1 KYNU FASN HEL-S-70p CHCHD3 PHB2 FKBP4 STOM SLC25A6 RAB35 PMPCA NIF3L1 PMC7754013__F1 MicroRNAs in osteogenic transdifferentiation of VSMCs ACVR2A STAB2 WNT7B RUNX2 IGF2 SAMD5 SAMD1 HEL-177 CTNNBIP1 RHOB HDAC5 HDAC2 MSX2 PMC6161739__F2 NLRP3 inflammasome assembly GSDMD NLRP3 TNF PMC7507121__F2 TGFB signaling pathway TGFBR2 CDK8 SMAD2 SMAD4 FURIN CDK9 PARP1 TGFBR1 PMC7468432__F1 Development and differentiation of Breg cells CD44 CD24 CD19 CXCR4 PREB PMC6161739__F1 Canonical and non-canonical inflammasomes.Notes: Canonical inflammasomes assemble downstream of cytosolic PRRs including NLRP1, NLRP3, NLRC4, AIM2, and pyrin and control the activation of caspase-1 NLRC4 NLRP1 GSDMD NLRP3 AIM2 IL1B PMC2803240__F8 Model of VA metabolism in neonatal rat lung CYP26B1 LRAT PMC6161739__F3 NLRP3 priming following TLR activation NLRP3 TLR3 TLR4 IRAK1 IRAK4 FADD MYD88 PMC7507121__F3 Tumor suppressor and promoting functions of TGFB signaling ANGPTL4 CXCR4 KRAS PMC7468432__F2 Activation of Breg cells CD40 BCR IL21R IRF4 MYD88 PMC5009326__F3 Integration of transcriptomic and genomic data suggests candidate mechanisms for APOE4-mediated pathogenic action in Alzheimer’s disease SHC1 HEY2 GDI2 APOE NUMB PSEN1 NRXN3 HDAC1 NCOR2 MAML3 RAB11A ADAM17 RAP1A OTX2 CREBBP APP SNW1 EP300 HES1 KAT2B KAT2A PMC8003624__F3 Fungal induction of necroptosis RIPK3 SYK TRADD BCL10 MLKL RIPK1 TRAF2 CARD9 FADD PMC4266326__F2A Comprehensive analysis of the transcriptional response of human decidual cells to lipopolysaccharide stimulation IL25 IL24 IFNB1 PMC4881529__F4 GPCR-mediated transactivation of EGFR EGF ADAM17 EGFR ADAM12 ADAM10 SRC PMC4286677__F8 Scheme of interactions hypothesized to connect the receptor protein Draper to the execution of the engulfment process CDC42 RHO SRC PMC4881529__F3 Diversity in GPCR-mediated regulation of Wnt/Beta-catenin APC GSK3B CTNNB1 PMC7236057__F8 Possible mechanisms of La2O3 NPs contributing to the apoptosis of testes tissues NPS CYP17A1 KEAP1 IL1B PMC4181723__F7 Proposed TLR signaling mechanism by CS14K: a hypothetical model of TLR4 signaling, pathway activated by fusion protein, in a MyD88-independent fashion STAT1 IRF3 TRAF6 TNF MYD88 PMC8361327__F2 Functional and Clinical Characteristics of Cell Adhesion Molecule CADM1 in Cancer CADM1 MIF TWIST1 PMC8361327__F1 Functional and Clinical Characteristics of Cell Adhesion Molecule CADM1 in Cancer FRMD6 CADM1 YAP1 PMC5534384__F2 The diversity and plasticity of adult hepatic progenitor cells and their niche LTB BMI1 EGF LTA HGF TGFA TNF CTNNB1 PMC7773908__F7 Positive crosstalk between epidermal growth factor receptor (EGFR) and the platelet-activating factor (PAF) pathway in cervical cancer cells LPCAT2 EGFR PC PMC7157599__F3 Molecular mechanisms used by members of the HECT E3 ubiquitin ligases to regulate Wnt, TGFB and Notch signaling pathways WWP1 UBR5 SMURF1 NEDD4 ITCH SMAD2 APC SMURF2 HUWE1 CTNNB1 PMC1828071__F2 Insulin-mediated activation of PI3K signaling pathways RHEB TSC2 EIF4B BAD PDE3B RICTOR TSC1 GSK3A PDK2 MTOR EIF4E PMC8472694__F2 Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism PSD MFN1 MFN2 PEMT GPR75 PC MCU PMC1828071__F3 Diagrammatic representation of insulin on growth factor signaling through the Ras-Raf, MEK-ERK signaling pathway with downstream effects on gene transcription through ERK translocation CRK GRB10 GRB2 PMC3501223__F1 Role of Esrrb in ESC self-renewal and reprogramming ESRRB TCF3 SALL4 LIF SOX2 PMC6450419__F4 Watch what you (self-) eat: Autophagic mechanisms that modulate metabolism HERC2 PINK1 NUFIP1 PARK2 SQSTM1 OPTN PMC3866688__F5 Targets of immunosuppressive drugs used in solid organ transplantation, according to the 3-signal model of T-cell activation CD40 CD80 CD2 JAK3 IL2 MTOR PMC7890028__F1 Wnt signaling pathways and their modulation by pharmacological molecules APC RYK CTNNB1 PMC5428427__F8 Proposed model for the suppression of inflammatory cytokine production by globular adiponectin in LPS-stimulated macrophages KEAP1 ADIPOR1 IL16 ADIPOR2 TRAF6 PMC6966193__F2 S1PC induces the degradation of MyD88 and Pax5 by activating autophagy PAX5 CCL2 XBP1 IRAK4 MYD88 PMC8484567__F6 Dramatic transcriptomic differences in Macaca mulatta and Macaca fascicularis with Plasmodium knowlesi infections SOCS1 CD40 CXCL9 MAVS CXCL1 IFIT3 SOCS3 TRAF3 ISG20 IFNG TLR4 USP18 OASL IL18 MX1 ISG15 IL10 STAT2 IRF9 DTX3L AIM2 IRF1 IRF3 IRF7 IRF8 CXCL10 ERFE IKBKB TRAF2 TYK2 PMC7889583__F1 Multiple MDSC-mediated immunosuppressive mechanisms STAT3 STAT1 ADAM17 COX2 IL16 APC ARG1 MMP9 MYC CCND1 CYBB MYD88 PMC3986565__F1 Molecular pathways leading to cross-presentation in DCs ERAP1 TAP1 TAP2 PMC3902304__F1 TWEAK/Fn14 signaling cascade RELA RELB TRAF5 TRAF6 FURIN TRAF2 PMC7889583__F3 Resistance mechanisms to MDSC immunosuppression STAT3 EBP TLR4 MYD88 PMC12250417__F4 Signal transduction mediated by BCR, FcRL1, CD19, and BCMA receptors on B-cells FCRL1 CDC42 SYK BTK SOS1 BCR PCNA PLCG2 CD19 LYN ARHA GRB2 PMC9598604__F1 Impact of an Adapted Physical Activity Program on Bone Turnover, Physical Performance and Fear of Falling in Osteoporotic Women with Vertebral Fractures: A Quasi-Experimental Pilot Study IL10 MSC IL6 PTH IL1B PMC9440249__F10 E-375i elicited anti-PCa effects MMP7 STAT3 BCL2 MMP9 PTPN4 PARP1 PMC12119567__F4 Immune-metabolic crosstalk in HNSCC: mechanisms and therapeutic opportunities PER2 SOAT1 MTOR PMC8389199__F8 Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway BAX KEAP1 NQO1 GCLC PMC10379831__F1 Deciphering the Signaling Mechanisms of Osteosarcoma Tumorigenesis TF BAD AXL SOX2 PTEN MTOR IL6 MYC TSC2 SOX9 BCL2 SMO ZEB2 MDM2 PMC7438746__F4 Transcriptional regulation by mTORC1 STAT3 NR1C1 MAF TFEB POLI HIF1A PMC3176402__F4 Zn and Zn transporters are indispensable for FcERI-mediated mast cell activation FYN ARHA GAB2 PMC7438746__F3 Indirect transcriptional control by AMPK through metabolites of intermediary metabolism OGA TET2 OGT TET1 TET3 SIRT6 PMC3547956__F6 Transcriptional and Gene Regulatory Network of Lactococcus lactis MG1363 during Growth in Milk OGT ADK RELA PURB PMC5334292__F1 The possible role of the polyol pathway in diabetes atherosclerosis TF NAMPT NDP PMC5105243__F2 Possible mechanisms for neuroprotective function of exercise and differences between sexes IGF2R DDIT4 KMO FGD4 GJB6 PMC3082570__F1 Simultaneous siRNA Targeting of Src and Downstream Signaling Molecules Inhibit Tumor Formation and Metastasis of a Human Model Breast Cancer Cell Line STAT3 BAD MTOR SRC CCND1 FOS PMC2322867__F2 Rapid Signaling Mechanisms of Estrogens in the Developing Cerebellum HBEGF EGFR GRB2 SRC PMC8551128__F1 Complement activation in IgA nephropathy MASP1 C6 CD59 FH MASP2 C2 C1S C1R CLK1 PMC4301092__F2 Examples of PTM-mediated biological processes PRMT1 PTMS MDM2 PMC3587843__F4 Lipids in The Control of Autophagy PI3 PC PIKFYVE PMC11097647__F6 B cell receptor signaling pathway-enriched Module_01 ICAM2 KNDC1 CACNA1A CD79B GCNT4 PCDH7 KLHL6 ZP3 CD22 CD19 PTPN6 CHRNB4 BLK CDK5R1 DGKA DMRTA1 FMNL3 TLR10 HRH2 ADA PMC5689203__F1 Schematic representation of secretory protein folding and quality control, the unfolded protein response pathway, and the heat shock response HSF1 HDAC6 PMC9171972__F2 YAP1 in liver cancer stem cells: proven and potential mechanisms LATS1 IGF2R LRP5 IGF1R IGF2 YAP1 CTNNB1 PMC3475803__F7 A model depicting ATM- and NEMO-mediated NFKB activation upon accumulation of prelamin A isoforms CXCL1 RELA ATM PMC3742223__F1 Ageing-dependent decline in thyroid activity, leading to compensatory increases in cellular D1 activity and thyroid hormone metabolites that may, through non-genomic pathways, be involved in amelioration of ageing related metabolic disturbances TRO INSR INS SIRT1 IMPACT PMC8204022__F4 MicroRNA-Based Network Provides Potential Predictive Signatures and Reveals the Crucial Role of PI3K/AKT Signaling for Hepatic Lineage Maturation NR1H4 GATA2 STAT3 MYB SLC10A7 EED SPRYD4 LIN28B TRIM32 TMEM64 BANP PIK3R1 HIF1A PNRC1 TCF4 HECW2 ATOH8 BMI1 KDM4A STAT1 LIN28A SNAI1 NHLRC3 CRY2 PAIP2 PDE4D CSF1R TIMP3 CPEB3 SIX1 SP1 KDM5B RUNX1T1 ERG ASCL2 FOS YAP1 ATF3 ACSL1 CEBPA FLI1 tal-1 CBFB TP63 PGRMC1 SIRT1 TWIST1 MAX KLF4 TP73 RELB E2F7 PTEN THRA RORA CTNNB1 FOXM1 NTF3 F2 NR3A2 BMP4 MEGF9 ATF4 FOXP3 CEBPB EGR1 E2F2 SOX2 SLC8A1 HAND2 GATA3 NR2A1 RUNX1 PSMD9 HOXB7 FOXO3A NFKB1 HOXA10 RELA NFE2L2 EP300 KLF5 ZBTB16 RPS6KA5 KAT2B PMC10373120__F5 Regulatory pathway involving lncRNA H19, miR-124-3p and ITGB3 in modulating ectopic endometrial cell proliferation and invasion in endometriosis ACTA2 ITGB3 PMC5077967__F8 microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NFKB CSF1 TRADD BCL2A1 RELA RELB CXCL2 REL CSF3 PMC6915012__F7 Schematic representation of the PAME-induced G2/M arrest in hBM-MSCs CDC2 MDM2 PMC10880550__F1 Effect of acetylcholine released from cholinergic neuron on heart, visceral smooth muscles and the brain KCNQ2 TRPC4 TRPC5 PMC9511018__F2 Non-cytotoxic functions of CD8 T cells: “repentance of a serial killer” CXCL9 IFNG FAS CCL3 CXCL10 PMC6061679__F1 Parkinson’s disease genes reveal an association of multiple variants that converge on deficiencies in cellular clearance COQ7 PINK1 RAB39B NPC1 LRRK2 ALAS1 TMEM175 SMPD1 SLC17A5 LAMP3 VPS35 HEL-S-130P KAT8 VPS13C MCCC1 PMC7118073__F7 Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression UFC1 EZH2 PTEN PMC10880550__F5 Complex interactions among GIRK, TRPC1/4/5 and KCNQ channels with GPCRs via G proteins A or BG subunits and PIP2 in neurons TRH TRPC4 TRPC1 TRPC5 PMC2173816__F3 Down-regulation of the inflammatory response CASP9 CASP3 PMC7946926__F8 Transport mechanism MAPK1 TEC PMC6596994__F7 A Conserved PLPLRT/SD Motif of STING Mediates the Recruitment and Activation of TBK1 TBK1 CGAS IRF3 PMC6905042__F2 Proposed mechanisms of Wnt/Beta-catenin dysregulation in ovarian cancer JRK RNF43 RAB14 TNKS CCNG2 LRP5 ZNRF3 LRP6 SOX7 CTNNB1 PMC3243033__F1 Regulation of epidermal homeostasis by PCP signaling CDC42 GPC4 CELSR1 CELSR2 ROR2 CTHRC1 PTK7 ARHA CELSR3 RAC1 FUZ GRHL3 VANGL1 DAAM1 PMC8721007__F2 Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy GLS HEL-S-133P CD36 HK2 HEL-S-5 CPT1A ACADM PMC6905042__F1 The Wnt/Beta-catenin signalling pathway APC GSK3B CTNNB1 PMC155355__F7 Model outlining the roles of GAI/RGA-like GA-signaling components in the plant life cycle RGL3 FGA PMC4562157__F5 Genes involved in metabolism (EMP pathway, TCA cycle, and inositol metabolism), rhizosphere adaptation, biocontrol, and plant growth promotion in SQR9 and their expression patterns in response to root exudates HEL60 COMP PGM2 XYLB THRA PMC8721007__F3 Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy PIG59 CD36 HEL-S-68p HK2 HEL-S-5 ENO1 GCK PMC7185105__F9 Hypothetical scheme of molecular and cellular events in the cochleae of aging Tg-B1 mice leading to accelerated hearing loss ULK1 MTOR PMC10380881__F1 Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity—A Multicenter Portuguese Cohort Study KDM1A DHFR MTRR TYMS MTR PMC3374856__F3 Mutations in glutamate signaling pathway and its associated proteins in melanoma GRM3 NRG2 NRG1 ERBB4 PSD NRG3 NRG4 PMC8866648__F2 Vascular Stem/Progenitor Cells in Vessel Injury and Repair DKK3 LRP5 LRP6 CCND1 CTNNB1 PMC12138082__F2 Antiviral mechanism of miR-124, miR-24, and miR-744 MAX STAT1 RARA HMGN1 MYC PMC8012850__F6 Schematic representations of the gene regulatory pathway controlled by Oc factors in the chordate retina PAX3 TMTC2 CPLX2 LHX5 SLC7A14 MAK PDE6D RXRG PAX6 PAX7 GABRA6 PROX1 NRL GABRA2 FOXN4 CACNA2D3 SCGN NR1A2 PMC2810615__F1 Simplified overview of the canonical Wnt/Beta-catenin signaling pathway LRP5 LRP6 CTNNB1 PMC7145982__F1 Autophagy process and regulation of ATG proteins by PTMs ATG101 ATG10 ALG12 ATG3 PINK1 ATG12 ULK1 UVRAG ATG5 ULK2 PMC10974036__F12 Recent Advances in the Nutritional Value, Chemical Compositions, Pharmacological Activity, and Application Value of Orychophragmus violaceus: A Comprehensive Review JUND KEAP1 MAF ATF4 PMC10937455__F1 The intrinsic immune system in the pathogenesis of GN NLRP3 CD14 MYD88 PMC12138082__F8 Vital role of the AMPK signaling pathway in cellular progress TSC2 TSC1 NR2A1 TXNIP CRY1 ATG14 MTOR PMC3917352__F1 Major metabolic pathways in tumour cells ACLY GLS HEL-S-133P HEL-S-26 PMC3403522__F2 Intracellular HIF-1A regulation pathway in normoxia and hypoxia HEL-S-133P EGFR MTOR VHL PMC4453221__F1 Wnt/Beta-catenin signalling pathway SOST APC LRP5 LRP6 SFRP1 PMC8830536__F2 Lipoprotein(a), a Lethal Player in Calcific Aortic Valve Disease LPA TLR4 CCR2 BMP2 RUNX2 CTNNB1 PMC12138082__F4 Proviral mechanisms of miRNAs STAT3 CXCL12 TBK1 MAVS IRF9 IRAK1 IRF1 IL6 TRAF3 TRAF6 MYD88 STAT1 RIPK2 MAP3K7IP1 GAB3 JAK1 TYK2 PMC12138082__F3 Mechanism of miR-342-5p regulating sterol metabolism STAT1 ABCG1 EVL HMGCR IRF1 IDI1 ABCA1 PMC11046063__F1 NRF2 signalling pathway RBX1 KEAP1 PMC2789670__F5 Summary of glutathione (l-Gamma-glutamyl-l-cysteinylglycine, GSH) homeostasis pathway identified in C BACH1 MAFF KEAP1 GCLM GCLC GLRX HEL-S-64p HEL-75 PMC9032805__F3 Tumor Microenvironment Drives Intrahepatic Cholangiocarcinoma Progression TMEM67 COX6A1 ATP6V1F MAP2K1 MAP2 RAB25 NOTO COXFA4 CP PMC6287681__F3 Signaling pathways by which NPs induce apoptosis BAX CASP9 CASP8 CASP6 CASP12 CYCS CASP3 BAK1 APAF1 FADD PMC6287681__F2 Signaling pathways that induce necroptosis RIPK3 CASP8 RIPK1 FADD PMC10145673__F2 Molecular pathways involved in pituitary tumorigenesis BAD EGFR APC PTEN IGF1R CTNNB1 LATS1 RHEB TSC2 TSC1 SUFU SMO MDM2 PMC10145673__F1 G-protein-coupled receptor (GPCR) signaling pathway EGFR AIP AHR MTOR SRC PMC12069192__F2 Regulation mechanisms of LMM proteins in rice RFWD2 RBL1 RAB5A C2 PMC6287681__F4 Autophagy signaling pathways induced by NPs ATG10 TG ATG3 ATG16L1 PIK3R4 ATG12 ULK1 PI3 ATG14 ATG5 PMC3185509__F1 Activation of antiviral and proinflammatory responses during HSV infections MAPKAP1 MAVS TLR3 TLR9 IRF3 IRF7 MYD88 PMC3185509__F3 Innate immune evasion mechanisms of HSV MAVS TLR3 TLR9 RNASEL IRF3 PMC3625183__F7 Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells PGP ARHA OTP PMC9179574__F3 Genetic Structure and Molecular Mechanisms Underlying the Formation of Tassel, Anther, and Pollen in the Male Inflorescence of Maize (Zea mays L.) SOS1 SPI1 PMC11357136__F2 Several modulator molecules linked to the signaling of GLP-1 receptor within the PI3K/AKT/mTOR pathway are demonstrated NGF RICTOR ULK1 PTEN PMC8431684__F2 Therapeutic Potential of Targeting the SUMO Pathway in Cancer SUMO1 RARA SENP1 PML PIAS1 ERG PIAS2 PMC8579463__F8 miR-34a-5p functions as a tumor suppressor in head and neck squamous cell cancer progression by targeting Flotillin-2 CDH2 CDK6 FLOT2 CDK4 PMC4882535__F5 Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine PARD6A CASP9 PGR HEL70 VEGFA ARHA CXCL8 MAPK3 EZR PRKCI PARD3 TUBB1 PRKCA CASP3 COL4A5 LCN2 LAMA3 RDX PS1TP5BP1 PMC4882535__F4 Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine PARD6A MAPK1 CASP9 PGR HEL70 VEGFA ARHA CXCL8 MAPK3 EZR PRKCI PARD3 TUBB1 PRKCA CASP3 COL4A5 LCN2 KDR LAMA3 RDX PS1TP5BP1 PMC5413082__F1 Schematic of growth hormone and IGF-1 axis IGF1 GHRH IGF1R GHR PMC9417995__F7 Schematic description of TRAF4/SMURF2-mediated regulation of HER2 signaling and Trastuzumab resistance in HER2+breast cancer cells TRAF4 MTOR SMURF2 PMC4655423__F1 Development of innate lymphoid cells IFNG IL25 TSLP ID2 IL33 AHR TOX NFIL3 IL1B RORA GATA3 RUNX3 PMC3117004__F2 Updated most likely pathway for acylCer formation (November 2010) ELOVL4 TG DGAT2 PMC2150790__F9 The signaling pathways activated by N CDC42 CD44 ERBB2 RHO GRB2 SRC PMC11983503__F3 Regulatory mechanisms of D-catenin associated with neural development and function SHANK3 RICTOR APC PMC6520728__F6 Schematic diagram for a proposed molecular mechanism of CFH regulation in lung cancers SOCS1 CFH STAT4 SOCS3 PMC11983503__F2 CTNND2 involved in the WNT/Beta-catenin pathway APC FGFR1 PAK4 HIF1A SETD6 CTNNB1 PMC2967651__F1 A model for interplay between alloimmunity and autoreactivity in graft rejection IFNG TH HEL-S-92n IL2 PMC7764362__F4 Main action mechanisms of chloroquine (CQ) and hydroxychloroquine (HCQ) related to antiviral and immunomodulators properties STAT1 TLR3 IRF9 TLR9 IRF3 IRF7 TLR7 PMC3343200__F5 IL-6 contributes to a positive feedback cycle of growth and invasion between CAFs (myofibroblasts) and its underlying tumor (afferent pathway) and between invading tumor and the recruitment of fibroblasts to myofibroblasts (efferent pathway) STAT3 EGF NOTCH3 PMC2697824__F3 Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: A review ATR RAD51 EGFR ATM PMC7764362__F2 Negative regulation of interferons (IFNs) by autophagy TBK1 MAVS STAT2 IRF9 TLR9 IRF3 IRAK2 IRF7 TRAF3 IRAK4 MYD88 STAT1 NLRX1 TLR3 IFNAR2 TLR4 IFNAR1 NOD2 TLR8 TLR7 TYK2 PMC3843069__F1 Tryptophan metabolic pathway HEL-S-90n KYNU AANAT ASMT AFMID DDC MAOA PMC11722366__F2 Key signaling pathways involved in kidney fibrosis TBR1 STAT3 SMAD2 TGFBR3 SMAD4 HEL-S-28 JAK1 TNF TYK2 PMC3291810__F8 PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling STAT3 RAF1 PAK1 PMC8833906__F1 Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia PCSK9 HMGCR SQLE DHCR24 INSIG1 PMC3147301__F3 Towards an understanding of the adjuvant action of aluminium TH NLRP3 IL33 MYD88 PMC4412056__F1 LC-PUFA biosynthesis pathway {adapted from Refs ELOVL2 FADS2 ELOVL5 FADS1 PMC5407765__F9 IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria CXCL9 IL33 CXCL10 PMC9613427__F1 Gain-of-function TLR7 and loss-of-function A20 gene variants identify a novel pathway for Mendelian lupus and lupus nephritis BCR IRF7 TLR7 MYD88 PMC7879300__F1 Toll-Like Receptors Regulate the Development and Progression of Renal Diseases TLR9 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC313952__F6 Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals EGF CBL SOS1 EGFR CIRSR GRB2 PMC11900975__F2 Multiple mechanisms of T-cell exhaustion induced by neutrophils in the TME STAT3 ALPL CD69 NTRK1 NAMPT PMC3594247__F1 Hippo on the move LATS1 LATS2 PMC8776955__F5 Calcineurin-dependent NFAT signaling as shared signaling pathway for IBD and SCZ RAN BAD NUP214 NFATC2 PPP3R1 PRKCZ SFN PPP3CA MAPK8 PPP3CC MAPK3 PRKCB MAP3K8 PRKCE FKBP1A CSNK2A1 HEL-S-1 HEL2 YWHAG NFATC1 MEF2D CASP3 BCL2 EP300 NFATC3 YWHAZ PMC11931784__F8 Heatmap of DEGs involved in the JA synthesis pathway LOX MYC PMC5110454__F1 DRAStic RHOAdblock of Pyrin inflammasome activation MEFV IL10 PKN1 HEL-S-62p IL16 PKN2 IL6 ARHA KRAS MVK PMC9482886__F2 AMPK regulation of the mTOR pathway and control of cell growth and autophagy RHEB MLST8 TSC2 TSC1 ULK1 DEPTOR PMC3926678__F5 Repetitive hypoxic preconditioning suppresses adaptive immune responses in resident B cells prior to stroke CD40 H2AB1 HLA-DOB HLA-DRB1 CTNNB1 HEL-S-99n STAT1 HLA-DRA HLA-E HLA-G CCR7 BAX IL12A STAT2 IL4 IRF1 IRF3 IRF4 TNF HLA-DQB1 SET IL17RA HLA-DMA CREBBP EP300 HLA-B REL BCL6 NFKBIB PMC5506009__F1 Functions of experimentally verified target genes of miR-17-92 were analyzed by GeneMANIA using genetic interactions, pathway, and physical interaction parameters SOCS1 GPR137B STAT3 FBXO31 MAP3K12 MYC FGFR2 HSF2 RB1 PTPRO ITGB8 BNIP2 E2F3 ZBTB7A NRAS CPEB2 KDR CCL1 BMPR2 CASP8 VEGFA DNAJC27 CDKN1A IRF2 BCL2 TWEAK KLF2 PTEN MYLIP TGFBR2 CCND2 NR3A2 F3 ATM APP ZNFX1 CCND1 THBS1 YES1 E2F2 SELE ARIH2 RBL2 KIT TSC22D3 NPAT BCL2L11 MEF2D JAK1 KAT2B PMC6770178__F1 Substance P/neurokinin-1 receptor (SP/NK-1R) system regulates several cell signaling pathways involved in cancer progression APC GSK3B RHO MTOR GPR49 CTNNB1 PMC4401129__F1 Tie2 (Tie2 tyrosine kinase receptor) structure and Ang-1-Tie2 signallingsignaling MAFK PLG ARG1 RAC1 PMC4364006__F2 The molecular regulation of autophagy ULK1 UVRAG VMP1 ATG14 PTEN RHEB ATG10 TSC2 ATG3 TSC1 ATG12 AMBRA1 ATG5 ULK2 PMC7654218__F6 Effects of extracellular antagonists in the Wnt/Beta-cat signaling pathway during the proliferation and differentiation in human osteoblast DKK4 DKK3 APC LRP5 LRP6 PMC3715701__F1 Myosin 1c in cellular signaling pathways CDC42 PAK1 CTBP1 SRC RAC1 IRS1 PMC6520171__F3 Depiction of RBP4 immunomodulatory actions locally within and how this gives rise to insulin resistance APC RBP4 IL1B PMC5501910__F3 Rescuing the BMPRII signaling pathway in pulmonary arterial hypertension SMAD1 DKFZp781O1323 SMAD4 PMC3660063__F3 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response RHEB BAX TSC2 EIF4B BAD TSC1 MTOR DEPTOR CTNNB1 EIF4E PMC8301375__F4 XBP1s in Transcriptional Regulation of Target Genes EP300 HIF1A MYC PIN1 XBP1 SIRT1 PMC3660063__F2 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response DUSP5 EGF EGFR GRB2 PMC3660063__F1 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response PIK3CA PIK3R5 ULK1 PIK3R1 IRS4 PTEN MTOR DEPTOR FKBP3 RHEB TSC2 TSC1 PIK3R4 NF1 PMC6928565__F1 Notch3 signalling and vascular remodelling in pulmonary arterial hypertension ADAM17 JAG2 ADAM10 RBPJ PMC8301375__F1 XBP1s in Transcriptional Regulation of Target Genes ELF2 ATF4 EIF2A XBP1 PMC6766623__F12 Molecular mechanisms by which pretreatment with monophosphoryl lipid A (MPLA) suppresses LPS signaling in the medullary thick ascending limb TLR4 IRAK1 MYD88 PMC12153709__F7 Graphical representation of the IL-4/IL-13 signaling pathway, including the genes described in Table 1 STAT3 IL13RA1 JAK3 CCL26 JAK1 TYK2 IL13RA2 PMC3069698__F1 The Fanconi Anemia and Breast Cancer Susceptibility Pathways FANCD2 ATR USP1 BRCA2 PMC8044463__F3 Metabolic genes regulated by Mondo family ACLY HEL107 KHK FAS DGAT1 HEL-S-133P TXNIP FACL4 GFPT1 DCT FADS2 ME1 ELOVL5 MOGAT2 FADS1 TG ACSL1 MTTP DGAT2 F2 SCD5 ELOVL6 PMC5916398__F1 Initial stages of the sensitization in contact dermatites TH TSLP TLR4 TNF IL1B PMC9304701__F1 Trained Immunity and HIV Infection TLR4 IGF1R ABCA1 PMC3660063__F4 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response RHEB MLST8 TSC2 TSC1 NF1 ULK1 PTEN GRB2 MTOR DEPTOR IRS1 PMC8082500__F8 KLF4, a Key Regulator of a Transitive Triplet, Acts on the TGFB Signaling Pathway and Contributes to High-Altitude Adaptation of Tibetan Pigs KLF4 CYR61 EGR1 MMP23B SMAD6 BCL6B KDR ATOH8 PMC4343072__F6 Consequences of mutant BRAF V600E in LCH ARAF BRAF MYD88 PMC8082500__F7 KLF4, a Key Regulator of a Transitive Triplet, Acts on the TGFB Signaling Pathway and Contributes to High-Altitude Adaptation of Tibetan Pigs KLF4 CYR61 EGR1 MMP23B SMAD2 SMAD6 SMAD4 BCL6B KDR ATOH8 PMC8131834__F2 Targeting Parthanatos in Ischemic Stroke PC AIDA SIRT1 PMC7916866__F1 Oxidative Stress, Plant Natural Antioxidants, and Obesity IGF1 NPY IGF1R AgRP IRS1 PMC8698543__F3 Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells BAX FAS TRADD TNF FADD PMC6210393__F7 MAPK signaling pathway from KEGG database MAX ECSIT EGF MAFK FAS RAF1 TRADD CD14 TNF MYC FLNA MEF2C NLK GRB2 PMC11978054__F5 Visualize interactions between the hub-genes in a co-expression blue module using GeneMAINA CAV2 LIN28B IGF2BP1 GPR65 IGF2BP3 ARHGEF37 NEURL1B SNTA1 UBE2E2 ANKRD36B MGLL CAPRIN2 KRT19 SOX6 HEPH PDE3A GCNT2 HBD COL4A5 LMCD1 CDK14 NR1A2 HBB PMC2785525__F1 The Anticoagulant APC Pathway TF APC PLG F11 PMC11076649__F8 JCYSTLF exerted an anti-senescence effect through regulating the HIF-1A/autophagy pathway in diabetic kidneys STX17 ATG5 PMC10139088__F6 Metabolic regulation on tumour metastasis SNAI2 SNAI1 PMC7010257__F5 miRNA expression in advanced Algerian breast cancer tissues ERBB3 EIF4EBP1 EGFR ERBB2 EZH2 MDM2 PMC7642854__F3 Endothelial dysfunction due to selective insulin resistance in vascular endothelium: insights from mechanistic modeling PI3 PTEN INS IRS1 PMC10139088__F5 Metabolic plasticity regulation on tumour microenvironment CIC FBP1 PMC2785525__F2 Cytoprotective APC pathway APC VCAM1 PMC7381294__F5 Differentially methylated genes enriched in the insulin signaling pathway RHEB TSC2 FAS TSC1 FOXO1 PDK2 MTOR INS EIF4E PMC3049195__F1 Proposed diphthamide biosynthesis pathway DPH1 DPH2 DPH3 DPH5 PMC7381294__F7 Differentially methylated genes enriched in the AMPK signaling pathway STAT3 FAS LEPR PMC7381294__F6 Differentially methylated genes enriched in the adipocytokine signaling pathway STAT3 NR1C1 LEPR SOCS3 PMC6770718__F1 Schematic drawing presents the detailed signaling pathways of breast carcinogenesis EGF HGF SMAD2 TRAF6 CTNNB1 PMC7172007__F1 Canonical Wnt/Beta-catenin signaling pathway and pharmacologic pathway mediators SFRP4 APC GSK3B LRP5 LRP6 CTNNB1 PMC4988654__F1 Major steps in the retinol signaling pathway of vertebrates HOXA1 RDH10 ALDH1A2 DHRS3 PMC2246264__F9 Proposed mechanism for MnSOD-mediated mitochondria to nucleus signaling and crosstalk with the IIS pathway RHEB DUSP10 NFKB2 PTEN REL PMC7211957__F7 Model illustrating the Thbs1/integrin/YAP signaling pathway in remodeling of vessel walls LATS1 LATS2 THBS1 PMC5342520__F2 Subpathway-LNCE: Identify dysfunctional subpathways competitively regulated by lncRNAs through integrating lncRNA-mRNA expression profile and pathway topologies CALML3 PLCD3 CAV3 SHC1 PPIF PPP1CC ZYX PTEN GNAL ATP2A1 ITPKA ACTN4 CCND2 ROCK1 PLCB1 ITPKC DGKZ PMC3160828__F1 More than just a T-box: the role of T-bet as a possible biomarker and therapeutic target in autoimmune diseases STAT1 STAT4 GATA3 IL12RB1 RUNX3 PMC8898375__F10 Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway SIRT3 ATL3 CPT1A SIRT1 PMC9286785__F5 BACE1: More than just a B‐secretase STAT3 LEPR BACE1 UCP1 PMC9286785__F4 BACE1: More than just a B‐secretase STAT3 BACE1 PTEN IRS1 PMC4191651__F3 Schematic illustrating mechanisms of SR-A intracellular signaling TLR3 MVP TLR9 IRF3 MYD88 PMC11977285__F3 Extracellular vesicles (EVs) in mitigating MASLD ADRB3 STAT3 HGF ARG1 FOXG1 PMC3356623__F6 Influence of Tc-axin and Tc-pangolin on canonical Wnt signaling and role of Wnt signaling in axis formation in the bilateria APC CTNNB1 PMC7263617__F4 Expression of high mobility group B1 and toll-like receptor-nuclear factor KB signaling pathway in chronic subdural hematomas HMGB1 TIRAP TLR4 IRF3 TRAF6 IRAK4 MYD88 PMC9219682__F1 Enhanced 3T3-L1 Differentiation into Adipocytes by Pioglitazone Pharmacological Activation of Peroxisome Proliferator Activated Receptor-Gamma (PPARG) LPL COX2 EBP PMC5920280__F1 Metabotropic actions of kainate receptors (KARs) in the regulation of glutamate release in the hippocampus CA3 HEL-S-11 PMC11968765__F2 Signal transduction mechanism of SWELL1 in different tissues and cells BAX JUN NSUN2 FOXO1 CDK2 BCL2 YBX1 GRB2 CCND1 PMC8660088__F6 System Pharmacology Model for Decoding the Synergistic Mechanisms of Compound Kushen Injection in Treating Breast Cancer SYK PIK3CA MYB JUN BAD RAF1 CD19 MYC CSF3 FOS RAC1 IRS1 CSF3R BCR TLR4 RXRA CFTR GRB2 AMH BDNF CCND1 PMC4096159__F2 Emerging Role of Autophagy in Alcoholic Liver Disease RHEB TSC2 TSC1 PTEN MTOR PMC11173950__F3 Oxidative stress: Nrf2 signaling pathway (adapted from Hammad et al RBX1 KEAP1 PMC11782603__F8 Using SEC-MX to provide molecular insights CDC2 ATR EIF4EBP1 RPS6KA1 DEPTOR RHEB MLST8 TSC2 TSC1 MAP2K4 GNS RPS6KB1 NPRL2 CHEK2 C16orf35 AKT1S1 DEPDC5 SESN2 CDK9 RRAGA PMC8544255__F4 Deregulation of the canonical Notch signalling pathway during CRC treatment CCND3 BCL2 ABCG2 HES1 PMC8544255__F3 Deregulation of the canonical Wnt/Beta-catenin signalling pathway during CRC treatment BCL9 APC USP22 LRP5 BCL2 LRP6 CTNNB1 PMC8911851__F6 Investigating the Neurotoxic Impacts of Arsenic and the Neuroprotective Effects of Dictyophora Polysaccharide Using SWATH-MS-Based Proteomics TMEM43 NF1 NRP1 COQ9 SEC11A TMED5 FAAH PMC5666614__F3 Lipids at membrane contact sites: cell signaling and ion transport ORAI1 STIM1 ESYT1 PMC7848762__F4 This network represents the interactions among the top-ranked genes participating in fusions in (A)T-cell acute lymphoblastic leukemia and (B) B-cell acute lymphoblastic leukemia KMT2A CCND3 LMO2 tal-1 LMO1 KIN PMC8544255__F2 Deregulation of the canonical PI3K signalling pathway during CRC treatment RPS6 BAD EGFR GAR1 PTEN MDM2 JAK1 KRAS GAB2 EIF4E PMC6781449__F10 Kindlin-3/leupaxin complex regulates paxillin tyrosine phosphorylation and podosome stability F2 F3 LIM2 PMC8544255__F1 Deregulation of the canonical MAPK signalling pathway during CRC treatment CDC42 MAPK14 STAT1 JUN RPS6KB1 BRAF ATF2 GRB2 KIN MYC KRAS PMC4702137__F8 Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu NUMB CCND1 CTNNB1 PMC5028860__F1 Red nodes indicate the query proteins and the proteins present in the dotted circles, VTN, PRKACA, RELA, EP300, AKT1, EIF2C1, are the common proteins associated with the query proteins ASIP RRP8 KAT5 HEY2 SPARC NRP2 VTN YBX1 VEGFA EPHB2 VEGFB XB RELA USP22 POMC NPY EP300 IGFBP7 KDR AgRP ATG5 PMC3985661__F8 Schematic representation of PARP1–TDP1 coupling for the repair of Top1–DNA covalent complexes TDP1 MRE11A PARP1 PMC10390051__F3 Enteric nervous system as a target and source of SARS-CoV-2 and other viral infections TMPRSS2 GFAP GDNF ACE2 IMPACT S100B PMC8774252__F2 Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3E) CRK DAB1 CDK5 VLDLR NDEL1 PMC5427221__F1 Various roles of C3 in complement activation and effector functions AFP BCR HEL-S-62p CR2 CD46 CR1 CP PMC8881125__F7 4-Octyl Itaconate Prevents Free Fatty Acid-Induced Lipid Metabolism Disorder through Activating Nrf2-AMPK Signaling Pathway in Hepatocytes FAS KEAP1 PMC8843894__F2 Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants CRP NLRP3 IL1B PMC5423858__F1 MicroRNA function in Drosophila memory formation POLL RAN POLI PMC7294616__F10 Anti-inflammatory signaling pathway mediated via OXA and OXR2 in ICH IL10 OXR1 HP PMC2925528__F1 Summary of the systemic involvement of choline-containing species and their potential relationship with inflammatory processes LTA PC PMC1850660__F1 Summary of established Beta-catenin pathways APC GSK3B CTNNB1 PMC4755791__F3 Toward an Orofacial Gene Regulatory Network MAX IRF6 GRHL3 SMAD2 dik TP63 SMAD4 KDF1 TFAP2C TFAP2B OVOL1 NOTCH1 PMC3537922__F1 Unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses CD40 TBK1 UNC93B1 TLR3 TIRAP TLR4 CD14 TANK IRF3 TRAF3 TRAF6 MYD88 PMC8662335__F7 REC8 enhances stemness and promotes metastasis of colorectal cancer through BTK/Akt/Beta-catenin signaling pathway BTK REC8 CTNNB1 PMC8650799__F3 Metabolic alterations reinforce pro- and anti-inflammatory macrophage phenotypes IFNG ARG1 IL1B PMC7164247__F8 Proposed model for antigen presentation by astrocytes in the PD brain CD80 PMC7858229__F1 Major forms of inflammatory cell death RIPK3 GSDMD CASP8 TRADD MLKL CASP3 RIPK1 DFNA5 FADD PMC6357482__F6 Schema of miR-21 regulated PTEN, PDCD4, SPRY2 pathway SPRY2 LPA PTEN PMC6357482__F8 Schema of miR-205 regulated ZEB1, ZEB2, EMT pathway ZEB2 PMC9317057__F1 Transcriptional Regulation of the Hippo Pathway: Current Understanding and Insights from Single-Cell Technologies LATS1 TAOK1 TAOK2 LATS2 AMOT TAOK3 RHO NF2 PMC9620778__F8 MAPK signaling pathway. The red nodes represent CN–NI-related genes MAX GAL FAS STH COIL CD14 APP TRAF2 PMC9098816__F2 Reactive Oxygen Species Induce Fatty Liver and Ischemia-Reperfusion Injury by Promoting Inflammation and Cell Death HMGB1 TNF MYD88 PMC8948417__F4 RET receptor signaling: Function in development, metabolic disease, and cancer NTS GDF15 GFRAL RET PMC8074527__F1 Mevalonate pathway involvement in viral mechanisms IPP RHOB FDPS ARHA PMC5777751__F6 Protein–protein interaction networks of differentially expressed proteins CXCR3 ChAT SRC PMC3295657__F6 Pathway model for interleukin (IL)-1A and tumor necrosis factor (TNF)-Alpha-induced inhibition of human skeletal muscle cell (HuSKMC) differentiation ALK SMAD2 ATF2 PMC7285260__F6 N starvation and disruption of cyto-nuclear coadaptation on allantoin synthesis and degradation PMC7864210__F1 ERA:E2 signaling network and crosstalk with growth factor signaling TF MTOR SRC PMC9104295__F3 Procyanidins and Their Therapeutic Potential against Oral Diseases BAD SMAD2 MTOR NOTCH1 PMC8203325__F4 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges TRADD TNF TRAF2 FADD MYD88 PMC8203325__F3 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges MMP2 MMP9 FURIN CCND1 PMC7081551__F1 Summary diagram of miRNAs, lncRNAs and circRNAs participated in the drug resistance of gastric cancer PMC5123688__F6 TLR8 couples SOCS-1 and restrains TLR7-mediated antiviral immunity exacerbating West Nile virus infection in mice BAX TLR8 TERT PMC6306791__F8 Possible molecular targets of the preventive effects of PT in Cr(VI)-induced ACD NLRP3 ACD IL1B PMC4479417__F10 PI3K-C2G is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling APPL1 PI3 MTOR PMC7996871__F2 PERK pathway and small molecule modulators KEAP1 BACE1 ATF4 QRICH1 PMC7996871__F1 Unfolded protein response (UPR) pathways KEAP1 ATF4 EIF2A XBP1 TRAF2 PMC4013413__F2 Roles of ALK in the pathogenesis of ALK+ anaplastic large cell lymphoma (ALCL) STAT3 BAD ALK SNAPIN JUNB MCL1 JAK3 GRB2 MTOR SRC IRS1 PMC11638488__F7 Mechanism of Trp in alleviating MS FGF8A CYP8B1 CYP7A1 FGFR4 CYP7B1 CYP27A1 PMC7772020__F1 Central metabolic regulation of ferroptosis SQLE ADA PMC7782843__F1 Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies CDC42 JUN BAD RAF1 SHC1 BRAF MYC KRAS RAC1 ARAF HRAS HSF1 BCL2 APP GCK GRB2 SRC TRAF2 PMC9468923__F5 Key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor IL16 AHR MTOR PMC4643087__F3 Ingenuity pathway analysis (IPA) revealed a key role for the Molecular Mechanisms of Cancer set of pathways MAX BAX JUN BAD CD2 APC CYCS RHO MYC IRS1 RBL1 CRK CBL NF1 SUFU PC BCL2 ATM SMO MDM2 GRB2 LEF1 FADD PMC9468923__F1 Key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor AHR AHRR CYP1B1 PMC4909418__F1 Smoothened-dependent and Forkhead box C1 transcription factor-induced Smoothened-independent Hedgehog signaling PTCH1 FOXC1 SMO PMC5973839__F1 Hyperglycemia enriches metabolic flux to glycolysis and five principal branches including the polyol pathway, pentose phosphate pathway (PPP), hexosamine pathway, protein kinase C (PKC) pathway, and advanced glycation end-products (AGE) pathway SORD HEL-S-49 HEL-S-162eP ENO1 GLO1 HAGH PMC7936150__F6 Heme and protoporphyrin IX biosynthetic pathway SLC25A5 ABCB6 ABCB7 FECH UROD UROS PMC8107692__F6 Resistin-Like Molecule A Dysregulates Cardiac Bioenergetics in Neonatal Rat Cardiomyocytes POLG2 TFAM NR1C1 PDK4 ACADS CPT1A ACADM POLRMT PMC4122349__F2 Serum miRNA Signature in Moyamoya Disease RHEB TSC2 EIF4B RICTOR TSC1 MTOR INS PMC9686909__F2 Systematic Review of the Therapeutic Role of Apoptotic Inhibitors in Neurodegeneration and Their Potential Use in Schizophrenia BAX FAS TNF FADD PMC2666541__F1 (panel A) ODC expression is regulated by a number of signaling pathways COX1 COX2 APC MYC PMC4478945__F8 Folate- and vitamin B-12–mediated one-carbon metabolism MTHFD2 DHFR TYMS MTR HEL-S-51e PMC11726948__F8 Summary diagram of AGH treatment in mdx mice MYOG FOXO1 DMD PMC5308739__F3 Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network EGF BAD TGFA RALA FRK AKT3 EPO JAK1 KRAS PMC2901551__F1 mTOR signal pathway PRR5 RHEB MLST8 TSC2 RICTOR TSC1 PTEN MTOR DEPTOR IRS1 PMC8185338__F1 Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria NR1i1 LAMP2 ATG3 ULK1 ATG14 MTOR ULK2 PMC11816720__F3 Molecular mechanisms of kynurenine pathway in liver diseases PPP1R15A KMO AHR CYP1A1 PMC12174442__F4 CO2-fixation metabolic pathways in autotrophic microorganisms ACLY HEL-S-162eP RTCA PMC11816720__F1 Kynurenine pathway (KP) HEL-S-90n IDO1 KMO IDO2 PMC5479626__F7 Illustration of Hippo-p53 pathway in megakaryocytes (MKs) LATS2 ARHA MDM2 PMC3731320__F1 Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway NOD2 TNF PMC6262325__F1 Canonical hedgehog signaling pathway KIF7 SUFU SMO PMC2754444__F5 T-Cell Activation Pathways Generated by HIV-Modulated Proteins ZAP70 CD3D CBL SHC1 CRKL WAS IL2 GRB2 NR0B2 SRC PMC5597599__F2 Model Signaling Network MCL1 PTEN HIF1A SOCS3 PMC5597599__F1 Model Signaling Network MAPK14 PTEN HIF1A ATF2 SOCS3 PMC8632388__F7 Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD ACLY NR1C1 NLRP3 GSTA4 CD36 TLR4 PC PTEN MTOR PMC9659888__F2 Noncoding RNA-mediated regulation of pyroptotic cell death in cancer NLRP1 GSDMD NLRP3 AIM2 IL1B PMC9659888__F1 Noncoding RNA-mediated regulation of pyroptotic cell death in cancer STAT3 GSDMD NLRP3 GSDMC GSDMB RIPK1 DFNA5 TNF IL1B FADD PMC11620901__F4 ACL injury management: a comprehensive review of novel biotherapeutics EGF TSC2 PAK1 SMAD2 SMAD4 ARHA PMC3269300__F1 DN Tregs employ multiple mechanisms to exert antigen-specific control over immune responses IFNG CD80 CTLA4 PMC5738678__F1 Functional mechanism of the Notch signaling pathway DLL4 JAG2 NOTCH3 DLL3 NOTCH1 PMC7991918__F7 Targeted molecular and biological pathways’ interaction map analysis performed on the genes from the red module CNDP2 HEL-S-77 PTPN1 PRNP HEL-S-99n HGS ACTR2 RAP2A VAPA FKBP1A SNX1 PFN2 SNAP25 HEL-S-87p HEL2 EHD1 PMC8552375__F1 NAD+, Senolytics, or Pyruvate for Healthy Aging? PC EPO PMC8611496__F9 Noni on cellular viability and osteogenic differentiation of gingiva-derived stem cells demonstrated by RNA sequencing and quantitative PCR THBS1 THSD4 SMAD2 SMAD4 NODAL ARHA TNF PITX2 TGFBR1 BAMBI IFNG RBX1 E2F4 FST BMP4 BMP2 NEO1 SKP1 PMC3956536__F5 Heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway CDC2 ATR RAD51 H2AX ATM CCNB1 PMC8417127__F2 Gut Microbiota in Lung Cancer: From Carcinogenesis to Immunotherapy CCR6 CCL20 PMC6081569__F10 Nuclear effects of DRD1/PKA pathway and reactive species on postsynaptic neurons CDK5 FOSB POLI PMC5892644__F6 Cycloartobiloxanthone Induces Human Lung Cancer Cell Apoptosis via Mitochondria-dependent Apoptotic Pathway BAX MCL1 BCL2 PMC8372480__F1 SARS-CoV-2 infection of islet B cells: Evidence and implications TMPRSS2 NRP1 ACE2 PMC7494909__F5 Intercalated disc protein XinB is required for Hippo-YAP signaling in the heart LATS1 CDH2 LATS2 NF2 CTNNB1 PMC3421055__F3 IMPACT OF ALTERED METHYLATION IN CYTOKINE SIGNALING AND PROTEASOME FUNCTION IN ALCOHOL AND VIRAL-MEDIATED DISEASES HEL-S-182mP PEMT PC HEL-S-61p PMC6416106__F2 Glutamine metabolism and macrophage polarization ABAT IL16 HEL-S-26 PMC9219854__F2 Importance and Value of Porcine Species in Sialic Acid Research ST8SIA4 NANP ST6GAL2 ST3GAL6 ST8SIA5 ST6GAL1 ST8SIA6 ST8SIA1 CMAS ST8SIA2 ST6GALNAC6 NANS ST3GAL1 SIAT4C GNE ST6GALNAC2 ST6GALNAC1 ST3GAL5 ST3GAL3 ST6GALNAC4 PMC5723588__F2 Haem synthetic pathway CPOX FECH UROD UROS PMC6287190__F1 Classic and alternative pathways of bile acids synthesis CYP8B1 BAAT CYP7B1 CYP27A1 PMC4918816__F2 Comprehensive Review of Pacritinib in Myelofibrosis SOCS1 PMC6822144__F6 Schematic diagram showing role of Tbx15 on adipocyte browning and obesity PRDM16 UCP1 ATF2 PMC6888001__F8 G Protein-Coupled Receptors (GPCRs)-Mediated Calcium Signaling in Ovarian Cancer: Focus on GPCRs activated by Neurotransmitters and Inflammation-Associated Molecules VEGFC EGFR PMC6523352__F2 Heme activator proteins (HAP) complex C6 MRPL11 MRPL40 C7 COX10 C9 CYC1 COX5A HEL-S-32 COX14 HEL-S-26 COX11 PMC9235271__F5 Metabolomics profile in acute respiratory distress syndrome by nuclear magnetic resonance spectroscopy in patients with community-acquired pneumonia CRP ALB CIT PMC8836080__F1 Genetics and Epigenetics of Bone Remodeling and Metabolic Bone Diseases LRP4 SFRP4 SOST LRP5 LRP6 PMC4789259__F1 Canonical miRNA biogenesis pathway RAN DGCR8 DDX1 DROSHA PMC3099728__F8 Molecular model of Foxo1 and IGF1/insulin regulation of osteocalcin expression IGF1 FOXO1 PTEN RUNX2 PMC4026919__F1 Wnt signaling pathway APC FGF9 GSK3B RYK RHO CTNNB1 PMC5294960__F1 Canonical and non-canonical TGFB signaling pathways TRAF4 SMAD2 SMAD4 MAP3K7 ARHA MTOR TRAF6 TGFBR1 PMC4695108__F3 Regulation of Bim in Health and Disease DNCL1 BRCA1 GADD45A USP9X PMC4705949__F10 Proposed mechanism utilized by HDACi to inhibit osteoblast-mediated protection of AML cells NHERF1 HEL-S-69p PPL PMC2648232__F6 Pathway mapping of OPC differentiation inducer genes DUSP10 MBP TRPC4 DLG4 NLGN3 PMC8742403__F9 ROS/PI3K/Akt and Wnt/Beta-catenin signalings activate HIF-1Alpha-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer HEL-S-133P HK2 ENO1 CTNNB1 PMC3146023__F3 Human spermatogonial stem cells: a possible origin for spermatocytic seminoma GDNF FOS RET PMC6297255__F8 Model proposing ROCK inhibition mediates morphological shift and neurite outgrowth-promoting property of OECs TGFBR2 L1CAM ARHA TGFBR1 PMC8188762__F2 SARS-CoV-2 plays a pivotal role in inducing hyperthyroidism of Graves’ disease TG TSHR TPO PMC8375263__F1 One Gene, Many Facets: Multiple Immune Pathway Dysregulation in SOCS1 Haploinsufficiency SOCS1 TIRAP MYD88 PMC4230790__F3 Key signaling nodes in prostate cancer that regulate epithelial plasticity CDH2 STAT3 CLU EGFR EZH2 PTEN IL6 ERG CTNNB1 PMC9322748__F11 Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor BAAT BACE2 GPX1 PMC9207015__F1 Molecular mechanisms of Shigella effector proteins: a common pathogen among diarrheic pediatric population TAB3 TRAF6 MYD88 PMC12010937__F7 Illustrated summary of the proposed roles of hepatic and intestinal FXR signaling pathways in TPHP-induced bile acid metabolic disorder and MASLD development in mice, based on the findings of this study TH CYP7A1 PMC4240281__F4 Molecular mechanisms of epithelial–mesenchymal transition STAT3 PTCH1 GSK3B HEL-S-28 SMO GRB2 TRAF6 PMC3960720__F8 Q43L mutant of neuregulin 2B is a pan-ErbB receptor antagonist NRG2 ERBB4 EGFR PMC7275069__F3 FOXF2 acts as a crucial molecule in tumours and embryonic development PAX3 TNFRSF19 TRAK1 PDGFA SHOX2 FOXF2 FGF5C TRAF6 EYA1 FOXF1 SLCO2B1 PDGFRA PTCH1 BMP4 SHH FGF18 PMC7275069__F2 FOXF2 acts as a crucial molecule in tumours and embryonic development VEGFC TIMP3 SP1 FOXC2 FOXF2 TWIST1 CTNNB1 PMC8391356__F5 Galanin during Bacterial Infection in Larval Zebrafish FAS MCL1 NGFR IL4 IL21R IL20RA CD40LG IL10RA MTOR IL6 TNF TGFBR1 CSF3R TGFBR2 IL17RA XCR1 GFAP PRL OSMR IL13RA1 IL6ST IL11 CSF1R PMC3961843__F1 Selected glucose metabolic genes and their potential roles in tumor development OGT HK2 GFPT1 GCK PMC4156617__F1 Updated working model for the AR showing a bifurcated signaling pathway downstream of cAMP/Epac PMC11083344__F4 BCAR3 in cell cycle progression CDC42 CDK6 CDK2 ARHA SRC CDK4 PMC7988727__F6 Prenatal indole-3-carbinol administration activates aryl hydrocarbon receptor-responsive genes and attenuates lung injury in a bronchopulmonary dysplasia model  TRADD TRAF2 PMC8203325__F2 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges RHEB TSC2 TSC1 PTEN GRB2 PMC8203325__F1 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges APC GSK3B LRP5 ARHA FLNA DAAM1 CTNNB1 PMC9051474__F2 Comparison of Metabolome and Functional Properties of Three Korean Cucumber Cultivars IPP PMC7483234__F3 Correlation of multiple markers of cell death signaling pathway in the hippocampal dentate gyrus (DG) of postmortem AUD human brain FAS TRADD TNFRSF25 PMC2570545__F2 EGFR signalling pathway in lipid rafts BAD PI3 EGFR PC MTOR PMC5712312__F1 Synthesis of glucosylceramide (GlcCer) and its complex glycoshingolipid metabolites GAL NHS GBA2 tmp_locus_29 PMC8122946__F6 Gene Coexpression Network Analysis Indicates that Hub Genes Related to Photosynthesis and Starch Synthesis Modulate Salt Stress Tolerance in Ulmus pumila GIP PMC3432059__F6 Establishment of Mouse Teratocarcinomas Stem Cells Line and Screening Genes Responsible for Malignancy SIAH1 ROCK2 STOM APC CER1 SKP1 ARHA NLK PMC8875122__F1 Fungal Colonization and Infections—Interactions with Other Human Diseases TH SYK IL16 MTOR CARD9 PMC6456212__F8 A carnosine analog with therapeutic potentials in the treatment of disorders related to oxidative stress SIRT3 COX2 PMC6885086__F4 Effects of sulforaphane on Nrf2 and NFKB pathways KEAP1 GSK3B MAF SFN PMC7868022__F4 EBV-induced oncogenesis through the MAPK signaling pathway ABI2 DUSP8 PMC7868022__F3 EBV-induced oncogenesis through the JAK/STAT signaling pathway STAT3 JAK3 SPIB BCL2L11 NKX6-3 HLX PMC5108588__F8 Hypothetical model explaining the dysfunctional Wnt–Beta-catenin signaling in PPARG deficiency GSKIP GSK3B APLN PMC5034935__F3 Proposed mechanisms by which the interaction of dietary long-chain n-3 polyunsaturated fatty acids from fish oil and butyrate from bacterial fermentation of dietary fiber may reduce colon tumorigenesis CASP6 CASP3 HEL-S-11 PMC7868022__F5 EBV-induced oncogenesis through the TGFB signaling pathway SMAD2 SMAD4 PMC7868022__F2 EBV-induced oncogenesis through the PI3K/AKT signaling pathway GSK3B CCL5 MTOR CTNNB1 PMC3928694__F2 TLR signalling pathways: TLRs signal through myeloid differentiation primary response gene 88 (MyD88) or/and TIR-domain-containing adapter-inducing interferonB (TRIF)-dependent pathways TLR1 TLR3 TIRAP TLR4 TLR9 IRF3 TLR7 TRAF3 TRAF6 MYD88 PMC7868022__F1 EBV-induced oncogenesis through the NFKB signaling pathway CDH6 PINX1 NKIRAS2 PMC12227979__F5 Exploring the Therapeutic Potential of Oxo berberine Compound in Arcangelisia flava Root Extract for Breast Cancer Treatment: Metabolite Profiling, Pharmacological Network Analysis, and In Silico and In Vitro Evaluation POR SYK TSC2 BAD BCR RBL2 NPB CD19 MTOR RAC1 EIF4E PMC4721599__F4 Network of genes located within high-level copy number changes and deregulated across all of the cell lines and tumors ATAD2 AURKA DKC1 PERP CDC6 PDLIM3 MYC TOP2A PMC6139685__F16 Tentative Model Explaining Redirection of Metabolism in the Absence of MDH2 during Photoautotrophic N Deprivation.FA degradation starts with hydrolysis of TAGs and membrane lipids by lipases FAS MAL MDH2 PMC6365454__F2 Chronic hyperglycemia impairs neuron function HEL-S-62p TRPV1 BDNF PMC4979470__F1 The NLRP3 inflammasome signaling pathway NLRP3 TNF IL1B PMC9183236__F9 Regulating alveolar formation through mitochondrial activity and distribution TFAM RHOT1 PDGFRA PDGFA MMD PMC6296439__F6 A model for the effect of JCAD CAD risk genotype on the Hippo signaling pathway LATS1 LATS2 JCAD RHO PMC4288261__F2 N-terminal tyrosine residues of SLP-76 on the canonical TCR signaling pathway JUN PLCG1 FYN CSK ITK GRB2 REL FOS LCK PMC3126106__F3 Chemosensory processing in the taste – reward pathway TRPA1 TRPM5 PLCB2 PMC4848008__F3 The HA/CD44 signaling pathway leading to the malignant phenotype of cancer cells CD44 STAT3 SOX2 CCND1 PMC3248170__F1 Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers ARAF BRAF IGF1R KRAS PMC4848008__F2 The hedgehog (Hh) signaling pathway and FAK cooperation with NANOG and p53 in the CSC phenotype PTCH2 PTCH1 SMO PMC5341142__F2 Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders EGR1 SP1 PDGFRA PMC7859453__F3 Activation of ERBB family receptors by growth factors can activate RAS MAPK signaling LPA EGF EREG RHO AREG PMC7859453__F2 MST activation center is the Hippo path EGF EREG NF2 AREG PMC7859453__F1 MOB, RASSF, SAV scaffolding proteins play an essential role in activating the Hippo pathway EGF EREG AJUBA NF2 AREG PMC7658374__F1 TGF beta SMAD-dependent signaling pathway TGFBR2 BMPR2 ACVR2A PMC4062952__F1 Four androgen metabolism pathways to DHT synthesis CYP17A1 AKR1C2 PMC6916680__F5 Suppression of proliferation and invasion and enhanced apoptosis of breast cancer cells by inhibition of expression of PI3K and its downstream signaling pathway by oxymatrine GSK3B CDK2 MMP9 CCND1 PMC10934115__F1 Genome-wide DNA methylation profiling identifies hypermethylated genes that are linked to regulation of multiple oncogenic signaling pathways in response to resveratrol (RSV) in breast cancer cells WNT16 RPS6KA2 AKT3 MTOR KRAS PITX2 PRKCB PTCHD1 PLCG2 PTCH1 PRKCA WNT4 MAML2 PMC10910747__F8 Working model: BMP9/BMP10/ALK1/SMAD4 Signaling drives the regulation of direct and indirect pathways in ECs BMP10 SMAD1 DKFZp781O1323 SELE SMAD6 SMAD4 HAS2 ERG PTGS2 ID1 CDK4 PMC4271587__F3 Flux map for accession 3231 (13C-MFA) MAL HP CIT PMC5964128__F3 Dex represses expression of phagosome formation-associated genes SYK LTA CLEC7A MARCKS VTN RHO PMC3606787__F8 Significant signaling pathway networks mined from nitroproteomic dataset TPD52L2 FCAR TGFB1 RAB31 NFRKB KLK11 TWIST2 IRAK2 PSMA2 SNAP91 ZNF267 FEZ2 BMF PLD3 UBB RHPN2 LIMA1 UBC PCDH7 PTPRK ARHA TNF FOS CAP2 GRIP2 ARHGAP5 TMOD3 RPN2 RAB32 BCL2 ESPN STC1 MMD PMC9476772__F10 Assessment of pulmonary infectious disease treatment with Mongolian medicine formulae based on data mining, network pharmacology and molecular docking KY RELA APP PMC9323014__F8 Runx2 in Microtubule Acetylation in Bone Metastatic Breast Cancer Cells ATAT1 RUNX2 HDAC6 PMC3434621__F5 Interactions of Rex with host pathways, uncovered and covered UBA2 SP100 CTNNB1 PIAS2 PMC3637685__F2 GAIT-mediated translational control HEL-S-162eP ELF3 EIF4E PMC2903975__F1 TLR signalling pathways: All TLRs except TLR3 share a common initial signalling pathway through MyD88 to the IRAK1/2/4TRAF6 complex TIRAP TLR9 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC5845754__F10 Proposed model for Marf-mediated ER stress in FRDA flies FXN FH PMC9448792__F8 Altered glucocorticoid receptor signaling in the diabetic proximal tubule FKBP5 ALDOB FBP1 PCK1 PMC12128433__F7 Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation IFNG PLCG1 CD69 APC IL2 PMC7427806__F5 New preclinical models for angioimmunoblastic T-cell lymphoma: filling the GAP ICOS HEL-S-162eP RELB CXCR5 EZH2 TRAF2 PMC8487962__F1 Complement activation and its effects in periodontitis MASP1 MASP2 HEL-S-62p PMC2940266__F2 Phosphatase and Tensin Homologue deleted on Chromosome 10: Extending its PTENtacles BAD APC GSK3B PTEN MDM2 CTNNB1 PMC2940266__F1 Phosphatase and Tensin Homologue deleted on Chromosome 10: Extending its PTENtacles BAD GSK3A GSK3B PTEN MDM2 MTOR PMC7427806__F4 New preclinical models for angioimmunoblastic T-cell lymphoma: filling the GAP TET2 ICOS ARHA PMC5316546__F1 Our strategy to increase seed oil accumulation by overexpressing the plastidial pyruvate transporter BASS2 under the control of a seed-specific promoter in developing A ABCA9 FAS HEL-S-5 PC GPT PMC8349734__F5 Drug-repurposing against COVID-19 by targeting a key signaling pathway: An in silico study HSP90AB1 BCL2 PMC8349734__F4 Drug-repurposing against COVID-19 by targeting a key signaling pathway: An in silico study FAS BCL2 PMC11941171__F11 Mechanism of action of SJB2-043 in A549 cells USP1 MTOR CTNNB1 PMC7659166__F4 CeRNA network directly associated with hypertensive nephropathy AKT3 TUG1 PMC7188552__F2 Bile acid synthesis pathways CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC4475396__F1 REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination MAD2L2 CDC20 BRCA1 APC RIF1 POLN PMC6970952__F3 Pathview analysis of the EGFR tyrosine kinase inhibitor resistance signaling pathway STAT3 EGF PIK3CA BAD TGFA HGF SHC1 EGFR GSK3B BRAF PTEN IGF1R MTOR BCL2L1 PRKCA RPS6 BAX AXL VEGFA FGF2 EIF4E ARAF HRAS FOXO3A PDGFRA BCL2 FGFR3 JAK1 PMC7218056__F3 Hippo pathways in lymphocytes DOCK8 DENND1C ARHA FLNA RAC1 LATS1 MOB1A MOBKL1A LATS2 FOXO1 FOXO3A F3 RAB13 PMC4833475__F1 Insulin Signaling and Heart Failure TSC2 TSC1 IGF1 CD36 PDPK1 ULK1 GSK3B BCL2 MTOR IRS1 EIF4E PMC4243705__F4 CHROMOSOMAL INSTABILITY PATHWAY IN COLON CANCER TBK1 TIAM1 RHO GRB2 PMC10878151__F4 Phosphorylated SMAD2/3 signaling pathways regulate the process of HCC SMAD2 SMAD4 PMC10878151__F2 Crosstalk between TGF‑B/SMAD and other pathways JUN SMAD2 SMAD4 MTOR PMC10878151__F1 Structure of the SMAD family and overview of TGFB/SMAD and BMP/SMAD signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 HP PMC4389409__F2 Plant phytochemicals achieve hormesis through multifocal pathway inhibition PTEN MTOR SIRT1 PMC3996849__F3 Intestinal cholesterol absorption is a multistep process regulated by multiple genes TG ABCG8 ABCG5 MTTP HMGCR ACAT2 NPC1L1 HEL-S-5 PMC11855393__F5 Targets of immunotherapy in triple-negative breast cancer (TNBC) CD80 TIGIT LAG3 PMC11855393__F4 EGFR, FGFR, PI3K and MEK pathways and their potential inhibitors in triple-negative breast cancer (TNBC) EGF EGFR PTEN MTOR PMC3270101__F6 Pathway map related to cisplatin-induced hepatotoxicity based on proteomic and genomic analysis ASB1 MTTP GSTT2 FASN FBP1 APOB ARG1 MDH2 ARG2 PMC11855393__F3 Cancer stem cell-associated pathways and their potential inhibitors in triple-negative breast cancer (TNBC) STAT3 ECD SMAD2 LRP5 SMAD4 PTK7 LRP6 CTNNB1 PMC11855393__F2 AR and associated pathways and their potential inhibitors in triple-negative breast cancer (TNBC) CDK6 PTEN MTOR CDK4 PMC8403114__F2 Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis SOX9 IHH SCX PMC8355560__F2 An Overview of Novel Agents for Cervical Cancer Treatment by Inducing Apoptosis: Emerging Drugs Ongoing Clinical Trials and Preclinical Studies STAT3 HMGB1 FAS MSH2 EGFR SI ATM MTOR NOTCH1 SPP1 PMC7352566__F1 DNA Double Strand Break repair by Homologous Recombination or Non-Homologous End-Joining pathway RAD51 BRCA1 BRCA2 RIF1 SHLD3 SHLD2 PMC7284830__F1 Examined genetic variants involved in folate and vitamin D metabolic pathways MTHFD1 RFC1 DHFR MTRR HEL-S-11 TYMS MTR PMC9356005__F3 Underlying mechanism of Treg in skeletal muscle repair and regeneration IL33 AREG CCL2 PMC8617942__F2 Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus STAT3 LEP LEPR POMC NPY SOCS3 PMC8617942__F1 Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus INSR FOXO1 POMC AgRP MTOR INS PMC3904668__F1 CD180 is a close relative of TLR4 and together with BCR signaling can promote B-cell activation and differentiation BCR TLR4 CD180 VAV1 MYD88 PMC3626870__F4 Arsenic-mediated disruption of PI3K/AKT signaling pathway CDC42 BAD PTEN MDM2 MTOR RAC1 PMC6934036__F5 Inhibitors used for antitumoral therapy BCL9 RNF43 APC GSK3B LRP5 ZNRF3 CDK14 LRP6 TBP MYC GPR49 CTNNB1 PMC9929774__F5 Bioinformatics analysis of differentially expressed genes in diabetic foot ulcer and preliminary experimental verification KLF2 IGF1 INSR BNIP3 ATM PTEN NLK SKP2 INS PMC7045974__F2 Differential dependency network focused on the KEGG apoptosis pathway () BAX NGF BAD FAS CASP6 TRADD ATM TRAF2 FADD MYD88 PMC12080384__F2 Mode of action of non-coding RNAs in tumors STAT3 SP1 PTEN MDM2 PMC12080384__F4 Multifaceted roles of RBP-regulated non-coding RNAs in tumors FUS STAT3 PTEN HIF1A MYC DROSHA KRAS CD47 LATS1 RBFOX2 RBM25 TFRC PIGK UBXN1 NF2 HNRNPC PMC3350990__F2 Bioinformatic analysis of the differentially expressed proteins.The list of the MS-identified protein spots from 2D-DIGE was subjected to String (v DUSP3 HEL-S-72p DLAT GNB2 DLG4 G3BP2 PMC3253915__F2 Innovative Therapy for Classic Galactosemia - Tale of Two HTS EGF EGFR PTEN PMC12114667__F1 CK1E’s role in the Wnt/Beta-catenin signaling pathway VSNL1 SNAI2 BIRC5 SNAI1 APC MYC CCND1 CTNNB1 PMC4802755__F1 Schematic depiction on exogenous LIF mediated intra-cellular signaling pathways for robust self-renewal in mESCs STAT3 LIF SOX2 PMC8349295__F7 Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway HMOX1 GSTA3 KEAP1 PMC7432680__F1 Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes TG ABCG1 FAS CD36 TLR4 ATM ABCA1 PMC7985688__F6 Illustrative model of the mechanism underlying the neuroprotective effects of PROG and ALLO against ketamine-induced cognitive deficits EGFR PGRMC1 BDNF PMC8332860__F8 Doxycycline potentiates the anti-proliferation effects of gemcitabine in pancreatic cancer cells POR LOX OSM TLR3 MRO GEM H2AX TLR4 IL33 TNF FADD PMC9322447__F3 Fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2 TGFBR2 SMAD2 SMAD4 MMP2 TGFBR1 PMC8332860__F7 Doxycycline potentiates the anti-proliferation effects of gemcitabine in pancreatic cancer cells SYK MYB EIF4B BAD GEM MCL1 RBL2 PTEN CD19 RAC1 POR RHEB TSC2 BCR MEI1 APIP PMC8332860__F6 Doxycycline potentiates the anti-proliferation effects of gemcitabine in pancreatic cancer cells TH ATR BAD CAD GEM KITLG DAO POR LPA CRK CBL REN LPO MOS F2 SUFU SMO RET FADD PMC4074825__F3 FHIT-substrate complex as a signaling molecule EGF SRC FHIT PMC6826306__F6 Pathway enrichment analysis of genes with eQTL associations with identified disease-associated SNPs CD40 ZAP70 ORAI1 CD36 RFXANK ELL IL2RG RFXAP BLNK RAG2 CD19 AIRE ICOS BTK UNG TAP2 CD8A LCK ADA PMC10944245__F10 Cytotoxic effect of flavonoids resulted from nuclear factor erythroid 2 (Nerf-2), Ak strain transforming (Akt), and nuclear factor kappa B (NFƙB) pathways KEAP1 PTEN MYD88 PMC4338832__F2 Drug targets in the autophagic pathway to treat human cancers ULK1 PMC6842984__F1 Diagrammatic representation of known mechanisms of action of lithium in endocrine cancers BAX TBX1 GSK3B PAX8 BCL2 CTNNB1 PMC8027318__F2 Proposed model of signaling crosstalk for the BCR to induce CSR CD40 SYK BTK BCR PLCG2 RELA RELB TRAF3 TRAF2 AID MYD88 PMC7058824__F1 Vitamin D Metabolic Pathway CYP2R1 CYP27B1 GC DHCR7 PMC9267050__F2 Therapeutic Potential of the Restoration of the p53 Protein Family Members in the EGFR-Mutated Lung Cancer BAX EGFR MDM2 PMC7056731__F5 Interplays between Hippo signaling and ROS production LATS1 TLR1 LATS2 KEAP1 TLR4 IRAK1 TRAF2 IRAK4 MYD88 PMC8083902__F2 Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis TG PINK1 BNIP3 PMC8585639__F6 Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets RIPK3 GSDMD ADAM17 NLRP3 ACE2 IL1B PMC7056731__F2 Reciprocal augment of Hippo-YAP signaling and innate antiviral response TBK1 CGAS MAVS STAT2 IRF9 IRAK1 IRF3 IRAK2 TRAF3 LATS1 STAT1 LATS2 TLR3 IFNAR2 IFNAR1 JAK1 TYK2 PMC8001359__F9 ISL effect on TGFB1 induced epithelial-mesenchymal transition (EMT) in human endometrial cancer CDH2 TGFB1 SMAD2 SMAD4 PMC7056731__F1 Simple scheme of the Hippo pathway in mammalian cells LATS1 EGF LATS2 NF2 PMC8585639__F4 Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets TIRAP IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 RIPK1 TLR7 PMC7056731__F4 Crosstalk between Hippo-YAP pathway and NFKB signaling IL17RC TRADD CXCL1 TAB3 TLR9 IRAK1 TLR5 CXCL2 IRF3 TRAF3 TRAF6 IRAK4 MYD88 LATS1 TLR1 LATS2 MAP3K7IP1 TLR4 TRAF5 TLR8 TLR7 TRAF2 PMC7056731__F3 Mutual activation of Hippo-Yorkie pathway and Toll/IMD mediated anti-bacterial response in Drosophila FADD MYD88 PMC5037084__F1 Molecular mechanisms contributing to liver steatosis following hepatitis B virus infection TG FAS FABP1 SCD APOB PMC12034938__F8 Plantamajoside Promotes NGF/TrkA Pathway to Inhibit Neuronal Apoptosis and Improve Diabetic Peripheral Neuropathy BAX NGF BCL2 PMC7226887__F1 Role of PTEN in the control of cell signaling BAD FAS PTEN SIRT1 PMC6260831__F2 Deregulated Signaling Networks in Pancreatic Cancer STAT3 APC BRAF PTEN MTOR KRAS TEAD4 CTNNB1 LATS1 RHEB MOB1A TSC2 TSC1 CDK6 TEAD2 NF1 TEAD3 CCND1 CDK4 PMC11124422__F3 APS on ICIs, CAR-T therapy, and DC cancer vaccines within the TME CD80 MTOR PMC6771966__F1 Mutual interactions of the mitochondrial compartment with hepatitis viruses and the consequences on the infections IFNG TBK1 CGAS MAVS IRF3 IRF7 PMC11124422__F2 Mechanism by which APS induces apoptosis in cancer cells by interfering with the cell cycle, inhibiting signal transduction pathways, and inducing apoptosis STAT3 BAX TIRAP MTOR SOCS3 TRAF6 CTNNB1 MYD88 TRAF4 CDK6 TLR4 RELA CCND1 CDK4 PMC9144176__F1 Targeting Membrane Trafficking as a Strategy for Cancer Treatment GSK3B CCND1 CTNNB1 PMC9469619__F1 Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway FAM98A KIF7 SUFU SOX2 SHH SMO TWIST2 GLI3 PMC9469619__F2 Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway VEGFC KIF7 CDON BOC SUFU PTCH1 DHH SHH IHH SMO MYC GLI3 PMC8714827__F2 EGFR-Dependent Extracellular Matrix Protein Interactions Might Light a Candle in Cell Behavior of Non-Small Cell Lung Cancer EGF IGF1 FBLN5 EGFR VTN MTOR PMC7000168__F1 Summary of myocardial cellular effects and the injury response induced by doxorubicin FAS TLR4 NFAT5 BRCA2 CASP3 MTOR GATA4 PMC1783401__F6 Integration of Runx1 and the BMP signaling pathway into the SCL transcriptional network GATA2 SMAD1 RUNX1 BMP4 SMAD6 ERG PMC8714827__F3 EGFR-Dependent Extracellular Matrix Protein Interactions Might Light a Candle in Cell Behavior of Non-Small Cell Lung Cancer EGF EGFR PTEN GRB2 MTOR SRC MYD88 PMC8305424__F3A Genomic Approach to Delineating the Occurrence of Scoliosis in Arthrogryposis Multiplex Congenita CDC42 EGF TRIO PXN APC GNG12 ARHA FLNA HEL114 CRK GRB2 BAIAP2 LBP PMC7334043__F2 Primary metabolic pathways of R HEL60 AOX1 ACO2 ME1 PEX10 GPD1 LPA GPD2 HEL-S-49 HEL-S-32 IDI1 MDH2 HEL-S-26 PMC8613465__F2 Signaling pathways and intervention therapies in sepsis HDAC1 HMGB1 GSDMD PINK1 TLR4 AIM2 MTOR SESN2 PMC6155173__F5 RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation RIPK3 TRADD TLR3 MLKL TLR4 RIPK1 TNF PMC8613465__F1 Signaling pathways and intervention therapies in sepsis HMGB1 TBK1 CGAS TXNIP GPX4 EGFR HIF1A IRF3 MYD88 HDAC1 GSDMD MAP3K7IP1 ALK TLR4 IL18 PMC8613465__F3 Signaling pathways and intervention therapies in sepsis TF KLF2 TFPI EPOR APC PMC4427301__F4 Downregulation of Notch Signaling Pathway in Late Preterm and Term Placentas from Pregnancies Complicated by Preeclampsia HEY2 DLL4 JAG2 NOTCH2 NOTCH3 DLL3 PMC8516728__F2 Triumvirate of NFKB, inflammation and cytokine storm in COVID-19 TMPRSS2 STAT3 ADAM17 TRADD TLR3 STAT2 IRF9 IRF7 TLR7 ACE2 PMC8516728__F1 Triumvirate of NFKB, inflammation and cytokine storm in COVID-19 CSA2 RELB TNF PMC6784827__F1 Schematic presentation of mechanotransduction and inflammasome signaling SYK PKN1 NLRP3 PKN2 AIM2 ARHA PMC5882306__F7 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells CASP9 CASP12 CASP3 BCL2 ATF4 EIF2A DIABLO PMC5882306__F5 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells DBF4 CDC45 ORC6 CDC6 CDT1 ORC1L ORC3 ORC2 PMC5606087__F8 Connection among hub genes predicted on KEGG pathways AMOT HEL-S-1 YWHAG TGFBR1 PMC3646763__F7 Beyond the Binding Site: In Vivo Identification of tbx2, smarca5 and wnt5b as Molecular Targets of CNBP during Embryonic Development WNT5B SMARCA5 EGR1 TCOF1 CNBP PMC5882306__F4 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells MAX BAX ATR JUN BAD CD2 CYCS MYC DAO RBL1 CRK TG CBL CRB2 HIPK2 SUFU ATM F8 NLK GRB2 SRC UNK FADD PMC5882306__F3 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells JUP HEL-S-99n CANX EBP BCL2 GIP AMFR ATF4 XBP1 VCP TRAF2 PMC3684427__F5 The regulation of clot formation (colored entities) TF TFPI APC PMC3841024__F4 Representative ingenuity pathway analysis (IPA) of relationship between significant genes involved in the response to mechanical stretch and/or BIRB796 treatment in engineered cardiac tissues PDGFD CEACAM1 EREG IGFBP5 FOSL1 DGIC FOXO3A PTGS2 CALCA PMC8480435__F2 Example of oncogenic signaling and downstream metabolic and physiologic imaging changes during molecular therapies RHEB TSC2 TSC1 PTEN MYC EIF4E PMC8300228__F2 Antimicrobial Peptides from Black Soldier Fly (Hermetia illucens) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming FADD MYD88 PMC5858852__F7 Pathways enriched for genes associated with ovarian cancer ADH1C GLDC SOX17 MMP7 HEL-S-117 ASS1 FGF13 AOX1 HEL-S-53e FZD10 CKS2 EVI1 GADL1 WNT2B SFRP1 BAMBI CSGALNACT1 ATP6V1B1 FGF9 HSD17B2 PSAT1 LPAR3 PMC6518377__F1 The old dog POMC MC4R AgRP PMC4449096__F1 Signaling pathways through which macrophages regulate Beta-cell replication EGF EGFR SMAD2 CTNNB1 PMC2697617__F1 Live Longer Sans the AT1A Receptor EGF ADAM17 EGFR ARHA GRB2 MTOR IRS1 PMC3142910__F5 Schematic representation showing proposed role of TMPRSS6 regulation by the BMP6-SMAD signaling pathway and iron via ID1 BMP6 SMAD1 DKFZp781O1323 SMAD4 HFE TMPRSS6 ID1 HFE2 PMC3280674__F1 Fatty Heart, Cardiac Damage, and Inflammation LPL TG CD36 APOB PMC5149523__F3 PD-1/PD-L1 blockade enhances tumor rejection by activating T cells LAT MTOR LCK PMC2694804__F2 Summary of the pathways transduced by the primary cilium PDGFRA PDGFA SHH SMO PMC5149523__F1 Effect of PD-1 on major signaling pathways and subsequent metabolic reprograming in T cells LAT APC PTEN MTOR LCK PMC2864762__F13 CFTR Depletion Results in Changes in Fatty Acid Composition and Promotes Lipogenesis in Intestinal Caco 2/15 Cells TG RXRA APOB PMC4851838__F1 Recurrent genetic alterations and targeted therapies under investigation in iCCA ARID1A EGF ROS1 CDK6 EGFR BAP1 MTOR HEL-S-26 CCND1 FGFR2 PMC10143509__F3 Involvement of p53 in activation of interferon genes, of interferon-stimulated genes, and in feedback loops regulating these processes SOCS1 PARP10 CGAS MAVS STAT2 IRF9 IFIT1 IFIT3 IFIH1 GLIPR2 INPP5D IFIT2 IRF3 IRF7 STAT1 MX1 ISG15 JAK1 TYK2 PMC8913072__F8 Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling SOX9 GDF15 BCL2 MTOR COL2A1 PMC6776190__F10 Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs GSK3B SMO RAB23 GAS1 ZIC2 PMC9115561__F2 RNA Therapeutic Options to Manage Aberrant Signaling Pathways in Hepatocellular Carcinoma: Dream or Reality? BIRC5 EGFR CCR2 TERT MDM2 MTOR ARL4C MYC CCL2 CXCR4 CTNNB1 PMC8436520__F1 Phenotypic and immune functional profiling of patients with suspected Mendelian Susceptibility to Mycobacterial Disease in South Africa CD40 STAT1 STAT4 IRF8 ISG15 JAK1 TYK2 IL12RB1 PMC5210527__F4 Insulin signaling pathway is significantly enriched in human cycling genes (the hypergeometric test, p-value = 9.70E-7, E-ratio = 2.26) FAS CBL ASL INSR FOXO1 GRB2 PDK2 MTOR INS EIF4E PMC8141194__F1 Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review ATG3 ATG16L1 MTOR ATG5 PMC6196657__F1 Expression and regulation of hepcidin in brain cells STAT3 BMP6 TLR4 HAMP MYD88 PMC3404846__F1 Mechanism of the tandem DRA/N-Boc protection proposed in this study based on the known pathway TH BOC PMC5216829__F1 Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer PIGF KIT PTEN MTOR RET PMC5594543__F4 Influence of PM10 exposure on coagulation CPB2 F2 PLG PC PMC9133800__F3 Biological nitrogen fixation and prospects for ecological intensification in cereal-based cropping systems MYC NPL PMC4985183__F6 Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer TF NUP214 PML MYC CTNNB1 RB1 TRIM28 RPS3 NCOR1 ATM CDC2 CHAF1A TFDP1 APC RBL2 EZH2 RPA1 PARP1 NCOR2 CHD4 MCM7 PRKDC CREBBP CDK2 SNW1 ARID4A PMC4985183__F5 Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer TF NUP214 EGFR MYBL2 PML MYC CTNNB1 RB1 TRIM28 RAD9A CHEK2 ATM DMD POLE CDC2 TFDP1 APC RBL2 EZH2 RPA1 XRCC5 NCOR2 MCM7 TSC1 PRKDC PRKAA2 CREBBP POU2F1 CDK2 SNW1 MAP3K5 ARID4A PMC3774688__F1 Helicopter Perspective on TB Biomarkers: Pathway and Process Based Analysis of Gene Expression Data Provides New Insight into TB Pathogenesis CD40 MEFV COMP CD2 TNFRSF14 TRIB2 LRRK2 LAT MCL1 MARCKS BNIP3 PTPRC NAMPT CXCL2 ADD2 CCL2 CRK ACTR2 FCRLA HEL110 PTPRE SRC GAB2 PMC4985183__F3 Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer MYBL2 MYC MAPK14 RB1 PELP1 TRIM28 SNAPC4 TRIM24 POLE EIF2AK2 CHAF1A APC RPS6KA4 EZH2 MDC1 XPC XRCC5 CHD4 RAD21 MCM7 TSC1 SUPT16H RPN1 MCM6 SNW1 MCM2 SUV39H1 ARID4A ZCCHC8 NUP214 EGFR PML CTNNB1 LATS1 HSF1 ATM DMD CCND1 CDC2 WRN PTPN11 CBX3 KRAS RPA1 PARP1 STK39 FKBP5 PRKDC PRKAA2 PIAS1 CREBBP POU2F1 NEK3 REL NIPBL PMC8524440__F2 Applications of Magnetite Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future Perspectives CD80 CTLA4 PMC8145606__F11 Anti-Tumor Effect and Mechanism of Triterpenoids in Rhus chinensis Mill. on Reversing Effector CD8+ T-cells Dysfunction by Targeting Glycolysis Pathways in Colorectal Cancer IFNG FAS HEL-S-133P APC SCAI MTOR PMC6691976__F1 Metabolic pathways regulated during T cell differentiation RHEB LPA FABP5 HMGCR HEL-S-133P FASN FABP4 TRAF6 MYC PMC5541251__F6 Illustration of AHR activity in pituitary cells TF CDKN1A CDKN1B AIP AHR AHRR CYP1A1 PMC5806108__F3 Upstream cell signaling pathway of autophagy RHEB TSC2 TSC1 PTEN MTOR PMC7886651__F1 Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms IFNG STAT3 STAT1 IRF4 FOXP3 BCL6 GATA3 PMC5806108__F1 NSAIDs significantly induce autophagy HGF ATG12 MTOR ATG5 PMC7139730__F3 The autophagy-induced anti-HCC polyphenols signaling pathways ULK1 ATG14 PMC3114309__F1 The NFAT structure TF SP1 SP3 SP2 PMC7139730__F1 Major cell death pathways: Apoptosis, autophagy, and necroptosis RIPK3 TRADD ATG12 MLKL TNF APAF1 FADD PMC3613096__F2 Signalling pathways involved in airway smooth muscle contraction ARHA NOX4 PMC7493323__F1 CX3CR1/ Fractalkine signalling—different roles in Microglia: In Alzheimer’s disease, chronic neuroinflammation increases the pro-inflammatory stimuli such as LPS, TNFA and IL-6 in the CNS REST CX3CR1 PTMS PMC4515126__F1 Sirt1 controls the immune responses in macrophages NAMPT SIRT1 SIRT6 PMC9535406__F5 Role of TGFΒ and autophagy in early crebellum development CDH2 CDH8 NCAM1 SMAD2 SMAD4 CTNNB1 PMC8347150__F3 Impact of Hypoxia over Human Viral Infections and Key Cellular Processes NFX1 RHO MTOR PMC8347150__F2 Impact of Hypoxia over Human Viral Infections and Key Cellular Processes HEL-S-133P F2 HEL-S-162eP FASN HEL-S-26 PMC7642368__F5 Airway neutrophils are activated in intubated children with compared to children without PARDS S1PR3 CD63 MPO PMC3726753__F2 Morphoproteomic Profiling of the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Desmoplastic Small Round Cell Tumor (EWS/WT1), Ewing’s Sarcoma (EWS/FLI1) and Wilms’ Tumor(WT1) RHEB MLST8 WT1 TSC2 RICTOR FLI1 TSC1 EGFR PTEN IGF1R GRB2 MTOR PMC3039931__F1 Cytoplasmic tyrosine kinases in the activating signaling pathways utilizing ITAM-containing adapters TEC SYK RHO PMC8743650__F1 Mitochondrial dynamics and diabetic kidney disease: Missing pieces for the puzzle of therapeutic approaches PINK1 MFN1 ROCK1 MFN2 MIOX MFF PMC4301880__F1 Experimental design PIGP GPAA1 PIGH DPM2 PIGV DPM3 PIGU PIGT PIGO PGAP2 MPDU1 PIGF PIGN PIGW PIGA PIGX PIGB DPM1 PIGL PIGK PIGS PIGM PMC3039931__F3 Inhibitory pathways in innate cells utilizing ITIM or “inhibitory” ITAM signaling pathways TEC SYK NASP SIRPA RHO PMC5275769__F4 miRNAs enriched with OSCC target mRNAs of the neurotrophin signaling pathway BAX CRK JUN TNFSF6 RELA BRAF ARHA SHE BDNF KRAS PMC4671616__F7 TGFB Controls miR-181/ERK Regulatory Network during Retinal Axon Specification and Growth SMURF1 SMAD2 ARHA DROSHA PMC3039931__F2 Tyrosine kinase pathways leading to CARD9 and TLR signaling responses TEC SYK CARD9 MYD88 PMC7161517__F3 Renin-Angiotensin System Interaction With COVID-19Normally, angiotensin I (Ang I) is converted to Ang II via angiotensin-converting enzyme (ACE), which could be inhibited by ACE inhibitors ACE2 PMC7950759__F3 Smurf ubiquitin ligase activity and protein levels in cancers PRMT1 TRAF4 LCK PMC6330595__F1 Graphical representation of glutamine/2-HG pathway and therapeutics options in renal cancer based on Shelar et al L2HGDH D2HGDH HEL-S-26 PMC6611700__F1 Outside-in and inside-out signal transduction in myofibroblastic activation ARHA TNLG7C PMC10143579__F1 Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD HEL-S-90n KYNU KMO PMC3769666__F1 Extrinsic and intrinsic apoptotic pathways BAX TRADD PMC3382265__F1 Molecular network of protein degradation, amino acid metabolism, and behavior for NC-treated cells in comparison with TC extract-treated cells CRKL BIN1 IFIT2 TUBB TUBA1B DOCK2 GCG HEL-S-99n CORO1B SHROOM2 HEL-S-125m SCARF2 GRB2 GAB2 CP PS1TP5BP1 YWHAG PMC7234984__F1 Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between Attention-Deficit/Hyperactivity Disorder and obesity measures PPP1R3A CSNK1G2 CDK5 PLCL1 PPP2R3A PMC5819875__F2 Wnt/Beta-catenin signaling during early vertebrate neural development PORCN APC LRP5 LRP6 MYC TEF SP5 CTNNB1 PMC6857659__F1 TGFB signaling pathway and its role in tumor immune microenvironment CCL22 SMAD2 FOXP3 ID1 MYD88 PMC1885790__F3 Diagram illustrating how the Rb and p53 pathways are linked to form a complex tumor suppressor network BAX MDM2 MYC CDK4 PMC11125669__F1 Pattern recognition receptors (PRRs) involved in intracellular viral sensing and downstream signaling TBK1 STAT1 CGAS MAVS STAT2 IRF9 TLR9 IRF3 IRF7 TLR7 MYD88 PMC2993245__F2 Negative regulation of junctional stability in RPE by the PI3K–ROS circuit EGF EGFR PTEN SRC PMC6681176__F1 Immunometabolism in atherosclerosis IFNG NLRP3 TNF IL1B PMC6051466__F2 Low antiviral gene expressions at the time of antiretroviral therapy (ART) initiation in cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS) group IFIT1 IFIT3 IFIH1 IFIT2 IRF7 OAS3 CCL5 DHX58 IFIT5 IFI44 OASL MX1 TLR7 IFNB1 ISG15 OAS1 OAS2 EIF2AK2 PMC9549294__F5 Interleukin-1 receptor associated kinase 1 (IRAK1) is epigenetically activated in luminal epithelial cells in prostate cancer KLF3 CREB3 NFKB2 MYC RUNX2 ZNF135 ZNF331 STAT1 CREB3L4 ETV6 ZNF708 PAX5 HAL ZFP14 ZNF667 ETV4 ZNF343 ZNF189 ZNF816 SMO ZNF549 ZNF417 ZNF416 ZFP57 ZNF317 ZNF257 TMPRSS2 ETV5 ZNF354C ZNF454 ZNF530 ZNF701 JUN EWSR1 ETS2 SP1 ERG FOS TCF3 FLI1 ETV7 PMC9282724__F3 Models of autophagy dysfunction in neurodegenerative diseases FUS TBK1 UBQLN2 PINK1 SYNJ1 LRRK2 HEL-S-67p PARK2 SNCA GRN VCP CPD CHMP2B PICALM TREM2 FIG4 VPS35 CD2AP PLA2G6 OPTN PLD3 C9orf72 PMC4069269__F1 IL-18 signaling NLRP3 IL16 SIGIRR IRF1 PTEN TRAF6 GATA4 IL18BP MYD88 PMC6198264__F3 Pathway of biosynthesis and metabolism of testosterone, primary estrogens and progesterone during pregnancy CYP3A7 CYP17A1 HSD3B1 HSD17B1 CYP1A1 STS PMC8024309__F8 LncRNA MALAT1 promotes gastric cancer progression via inhibiting autophagic flux and inducing fibroblast activation ELAVL1 GC PTEN SQSTM1 MTOR PMC8549280__F1 SREBP (Sterol Regulatory Element-Binding Protein) pathway: a regulatory bridge between carotenogenesis and sterol biosynthesis in the carotenogenic yeast Xanthophyllomyces dendrorhous IPP MVD MVK PMC11674137__F1 DOX-induced cardiotoxicity in cardiomyocytes STAT3 HMGB1 TLR9 ERBB2 PMC11767473__F1 Importance of mesenchymal stem cells (MSC) in the bone-formation mechanism WNT10B HOXA2 BMP6 STAB2 RUNX1 FOXO1 MSC ATF4 RUNX2 SIRT1 PMC7977035__F1 Postlanosterol cholesterol biosynthesis pathway tmp_locus_29 EBP SC5D DHCR24 DHCR7 PMC5889750__F5 Platyfish significantly down modulate the IGF signaling pathway leading to a suppression of cell proliferation, cell growth and cell survival in skin following FL exposure STAT3 BAD GRB10 NEDD4 IGF1 PXN GRB2 JAK1 PMC3047613__F2 Model: The kinase IKK may activate Htt degradation by a mammalian version of the yeast Cvt pathway RHEB CDK5 SIRT1 HTT PMC11674137__F2 Landscape of the mitophagy mechanisms TBK1 PINK1 SMURF1 ULK1 MUL1 FUNDC1 OPTN PMC5889750__F9 Platyfish skin (A) significantly down modulates the PPARA/RXRA signaling pathway in response to FL; however, both medaka (B) and zebrafish (C) significantly up-modulate the PPARA/RXRA pathway in skin following FL exposure JUN NR0B2 TRAF6 PMC5889750__F8 The telomerase signaling pathway is oppositely modulated in platyfish (A) compared to medaka (B) and zebrafish (C) following FL exposure TERT SHE PMC5889750__F7 In zebrafish following FL exposure, the most significantly modulated pathway in skin is the oncostatin M pathway MT2A OSM MMP3 GRB2 PMC5889750__F6 Acute phase signaling pathway in fish ECSIT TRADD C2 HRG HP MTOR PLAA PMC5397662__F2 A simplified diagram showing the major steps in short-patch base excision repair pathway PMC9575659__F9 Comparative physiological, transcriptomic, and WGCNA analyses reveal the key genes and regulatory pathways associated with drought tolerance in Tartary buckwheat HSF2 HSF4 PMC3439829__F4 Diverse cohesinopathy phenotypes PDS5B MAU2 PDS5A ESCO1 HDAC8 WAPAL ESCO2 NIPBL PMC4724579__F2 Toll-like receptor 2’s signalling pathways contributing to hepatocarcinoma HMGB1 PMC4724579__F5 Toll-like receptor 9’s signalling pathways influencing hepatocarcinoma HMGB1 TLR9 PMC8366499__F1 Genetic and Physiological Effects of Insulin on Human Urate Homeostasis GRB2 ABCG2 SHE PMC4724579__F4 Toll-like receptor 4’s signalling pathways influencing hepatocarcinogenesis HMGB1 TLR4 PMC3121779__F15 Protective effects of OxPLs against acute lung injury and endothelial barrier dysfunction CDC42 HEL164 CD14 RHO LBP CTNNB1 PMC6856358__F8 Proposed signaling pathway of this study IGF2BP1 EGFR MAGEA6 MTOR MYC IGF2 PMC5415275__F9 The putative role of central insulin resistance in attenuating leptin modulation of rHypoE-19 hypothalamic neurons STAT3 FOXO1 SOCS3 PMC2937585__F1 Folate metabolic pathway DHFR PMC7720011__F3 Possible relation of prostate cancer to viral pathogenesis SPINT1 PRDX3 PIM1 ZEB2 ERG HEL-S-97n ACE2 PARP1 PMC10179893__F5 PS inhibits macrophage M2 polarization via IL-4/STAT6 signaling pathway, and in turn suppresses TAM-induced tumor progression ARG1 PMC7720011__F1 Functional pathway of androgens and its receptor TMPRSS2 TGFB1 PTEN ERG PMC4394497__F11 Findings from our laboratory using an animal model of the autoimmune disease, RA, reveal disease-related changes in B2-AR signaling that are dependent upon the lymphoid tissue examined ADRBK1 PMC10534981__F1 Biomedical engineering approaches for the delivery of JAGGED1 as a potential tissue regenerative therapy HPDL HES1 PMC5851248__F5 Summary of excitotoxic pathways, mediators and potential therapeutics PANX1 PTEN PMC3884689__F7 Modulators of the microRNA biogenesis pathway via arrayed lentiviral enabled RNAi screening for drug and biomarker discovery HEL-S-22 ADAR SMAD1 RAF1 SMAD2 TGFBR1 HNRPR RBBP7 MAPK14 HSPA2 SRPK1 NDUFB7 RIPK1 ATF4 APAF1 DNMT3B MAPK1 DICER1 SNRPA EZH2 DROSHA RPS7 PITPNM2 HDAC1 HGS UBE2V1 ATF3 RUNX1 NONO BRCA1 ACTN4 OGDH RHOB RXRA SH3BP4 PMC6659691__F3 Interferon-gamma (IFNG) pathway and its modeled representation to demonstrate the step-by-step calculations for protein-protein interactions at each node in this pathway and as an annexure section of other pathways IL15 CD40 CXCL9 CD80 FAS CD36 MCL1 CXCL1 MYC CCL2 IFNG STAT1 IFNGR2 FYN CCND2 CHUK HEL-S-11 KIN CCND1 IFNGR1 IL12A CXCL2 CD40LG IL17A VEGFA IRS1 NFKB1 IKBKB RS1 CCL4 IL8RB JAK1 CXCR4 GAB2 PMC6659691__F2 A modeled signaling pathway using a G Protein Coupled Receptor activation as an example GNAS OTP PMC12137166__F1 CA PD-OTC of CZ019 displays enhanced glycolysis and noncanonical Krebs cycle metabolism GOT2 DCX GLS HEL-S-62p OTC HEL-S-32 ME1 HEL-S-30 PMC5312414__F1 Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway RHEB TSC2 PTEN MTOR PMC2556249__F2 Insulin receptor signaling PI3 GRB2 IRS1 PMC6659691__F1 Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer CD40 CD80 IL10 IF2B1 CSF2 IL13 IL4 CD40LG VEGFA TNF CXCL10 IFNG IFNGR2 TLR4 IL18 IL2 CCL20 PMC5478692__F1 Schematic overview of Imd pathway in Drosophila melanogaster RHD CYLD FADD PMC8221540__F8 Immunometabolic Endothelial Phenotypes PDK4 FOXO1 F2 PMC3928701__F1 Normal signaling pathways and alterations in aged DCs in response to lipopolysaccharide (LPS)/bacteria (A), and in response to self antigen (DNA) IRF3 IL6 MYD88 PMC5773512__F6 Schematic to illustrate calcimimetic R-467 reversed Cd-induced signaling pathways, followed reinstated intracellular Ca2+ level and ROS generation, restored autophagic flux, alleviated cell apoptosis and stimulated cell proliferation CASR NPS CD2 PMC5609950__F9 Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma BAX LEFTY1 BCL2 PMC5354695__F1 Long noncoding RNAs in head and neck cancer DNMT3B CDK6 TSHR FOXC1 EZH2 PTEN VEGFA PMC9433211__F2 Ferroptosis and Its Relationships with Other Types of Programmed Cell Death: Insights for Potential Therapeutic Benefits in Traumatic Brain Injury SI CYLD PMC10526262__F2 Importance of M1-and M2-Polarized Macrophages in Glioma and as Potential Treatment Targets CHI3L1 LGALS3BP GSK3B METTL3 MTOR PMC3377006__F1 Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression FOXP3 PMC10243706__F1 Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies STAT3 TLR4 SIGIRR IRAK1 TLR5 MYD88 PMC8535782__F1 Control of ovarian follicle development by TGFB family signaling BMP15 BMP4 GREM1 BMP2 KIT GREM2 GDF9 PMC4945497__F1 Epigenome-wide DNA Methylation Analysis Implicates Neuronal and Inflammatory Signaling Pathways in Adult Murine Hepatic Tumorigenesis following Perinatal Exposure to Bisphenol A IRF9 MTOR PMC11622655__F1 Effect of Triolein on brain damage after ischemic stroke IL10 IL6 MTOR PMC4945497__F2 Epigenome-wide DNA Methylation Analysis Implicates Neuronal and Inflammatory Signaling Pathways in Adult Murine Hepatic Tumorigenesis following Perinatal Exposure to Bisphenol A MAX EGF FAS RAF1 EGFR FRK CD14 TRAF6 DAO FLNA MOS NLK TRAF2 PMC9453879__F7 Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPARA pathway in diabetic rats LPL UBC PC UCP1 HEL-S-28 PLTP ACP7 PMC6986448__F3 KISS1 in breast cancer progression and autophagy MED23 GNRH1 MMP14 SP1 TFAP2A MMP9 FOS IGF1 MMP24 PRL NFKB1 RABEP2 RELA SP3 MMP2 MMP3 NPY SND1 PMC6176931__F3 Multiple phases and regulation of cilium assembly RAB8A KCTD17 MARK4 INPP5E NDEL1 EHD1 PMC10873884__F3 Different self-incompatibility systems ROS1 FER MAPK9 GLO1 PGAP1 PMC6804657__F1 Autophagy induced via cGAS-STING and its signaling pathway AMN CGAS WIPI2 SEC24C PMC7915848__F4A Increased Tenascin C, Osteopontin and HSP90 Levels in Plasmatic Small Extracellular Vesicles of Pediatric ALK-Positive Anaplastic Large Cell Lymphoma: New Prognostic Biomarkers? RPS15A STAT3 PTX3 TNC EGFR C4BPB VTN GANAB NCAM1 C9 APP CRP HSP90AB1 SAA1 TNFAIP6 JUN NRP2 RPS27A VEGFA SPP1 VCAN OMD ITGB1 HEL-S-125m FAM20A B4GALT2 LBP PMC9657932__F6 Enhancing an Oxidative “Trojan Horse” Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside HEL-S-162eP FES KRAS PMC11354614__F2 Glucose and stress metabolism DDT CA4 CA7 GPX1 CA8 CA3 CA12 PRDX3 PRDX5 HEL55 AGL PFKM NNT CA14 HEL-S-44 HSP90AB1 ANXA9 HEL-S-72p PYGM HEL-S-101 HEL-S-67p CA13 HEL-S-133P ANXA10 ANXA6 LDHB GLO1 HEL-S-30 ANXA11 PGAM2 CA11 ENO3 HEL-S-68p CAND2 GYS1 HEL-S-162eP HEL-S-49 HEL-S-102 ENO1 TRIM72 HEL-S-87p CA9 PMC10531451__F6 Heatmap of DEPs participated in the mevalonate (MEV) and methylerythritol phosphate (MEP) pathways of terpenoid biosynthesis IPP MVD PMC6442683__F4 Dendritic structural plasticity and neuropsychiatric disease EEF2K TRIO TARP EEF2 ARHA MTOR BDNF PMC1440856__F1 Omega-6 and -3 fatty acids & Prostate Cancer COX2 C2 ALOX15 GLA ALOX15B PMC6442683__F3 Dendritic structural plasticity and neuropsychiatric disease CACNA1C CACNG2 TRIO DLG4 KALRN RAC1 SHANK3 SYNGAP1 CAMK2A DLGAP1 NF1 PSD PRRT2 CASK CACNB4 NLGN3 NRXN1 PMC8799442__F1 Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients PANX1 TRPM2 PIR ADA PMC9271571__F1 NFKB Inducing Kinase Regulates Intestinal Immunity and Homeostasis C2 RELA RELB TRAF3 REL TRAF2 PMC8295173__F1 T cell metabolism drives T cell fate and function in to eliminate tumors CD80 APC ARG1 CTLA4 PMC7653700__F3 T cell senescence-related signaling pathways ZAP70 STAT3 STAT1 CGAS MAP3K7IP1 ATM TERT MTOR GATA4 LCK PMC4646736__F2 Proposed pathway of prostaglandin synthesis and interaction with the cyclooxygenase pathways and VEGFA COX1 COX2 VEGFA PMC8042281__F1 Pre-existing chromatin features and damage-induced histone modifications regulate the DNA repair pathways H2AX SETD8 KMT5C KDM5A KDM3A KMT5B EZH2 KDM4B ME1 KDM4A ME3 HDAC1 KDM6B tal-1 ME2 KDM2A SETMAR KDM5C KDM4D PMC8042281__F3 Histone modifications, dynamically added or removed around the DNA damage site, constitute an integrated signal for the DSBs repair pathway choice RAD51 H2AX SETD8 KMT5C KMT5B ME1 VCP KDM4A ME3 BARD1 HDAC1 L3MBTL1 BRCA1 ME2 RNF168 KDM2A SETMAR PRC1 RNF8 MBTD1 PALB2 HDAC2 PMC4131284__F6 CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11p110 BRCA1 PML ATM PMC5485420__F10 Graphical representation for Mel regulation in DRG neurons MAPK1 CACNA1B ME1 IL1B RORA PMC5336175__F10 Differential phosphorylation of YBX1 on Ser-176 and Ser-165 and their role in NFKB activation CTRL YBX1 IL1B PMC8540409__F6A Metabolomics Investigation of the Metabolic Changes of Raji B Lymphoma Cells Undergoing Apoptosis Induced by Zinc Ions GPCPD1 PLCG1 EGFR LYPLA1 PC GRB2 PMC7072361__F1 Potential role of podocalyxin (PODXL) in mature B-cell non-Hodgkin lymphoma (B-NHL) progression CXCL12 NHERF1 FASN PMC9306053__F3 Mitochondria dysfunction in CD8+ T cells as an important contributing factor for cancer development and a potential target for cancer treatment: a review OPA1 FOXO1 MFN1 MFN2 PMC4540474__F6 HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation MAP3K7IP1 TAB3 RNF8 PMC4959441__F1 RAS-mediated signal transduction pathways and post-translational modification of RAS RALB RALA EGFR COCH RCE1 MTOR PMC7396046__F2 Suggested signaling pathway for glucose-induced increase in glucagon synthesis, glucagon secretion, and alpha cell proliferation EGFR MTOR SRC PMC9657932__F2 Enhancing an Oxidative “Trojan Horse” Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside EGFR PTEN GRB2 PMC8197596__F1 Severe COVID-19 in Alzheimer’s disease: APOE4’s fault again? MMP14 APOE RELA ACE2 SIRT1 NOTCH1 CTNNB1 LZTFL1 PMC7504526__F4 mtDNA-triggered cGAS-YAP pathway LATS1 TBK1 CGAS YAP1 PMC6910929__F3 Regulation of PI3K/AKT signaling pathways BAD PTEN PMC12012199__F7 Targeted demethylation of EphA7 inhibits tumorigenesis via the SP1/DNMT1 & PI3K/AKT axis and improves the response to multiple therapies in cervical cancer EFNA5 SP1 EPHA7 PMC7313447__F7 Astragaloside IV attenuates high glucose-induced EMT by inhibiting the TGFB/Smad pathway in renal proximal tubular epithelial cells CDH2 SMAD2 PMC5265847__F3 TP53-centered protein–protein interaction network identified based on the Level 2 gene set using Ingenuity Pathway Analysis F11R PYHIN1 OSM TP53BP2 TNFRSF9 TNFSF6 IL2RA CD133 PTPN6 NOX4 BTG1 CHMP4C KLF5 RGS13 DACH1 NOTCH3 LPP SOX4 PMC7419982__F5 Sodium (Na+) and potassium (K+) ion homeostasis by SOS pathway SOS1 SOS2 PMC6627931__F1 Role of Leukotriene B4 Receptor-2 in Mast Cells in Allergic Airway Inflammation LTB TLR4 IL33 MYD88 PMC4700430__F2 Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: integrative genome-wide and candidate gene analyses HEL-S-11 ACR PMC4037924__F1 Ancestral Ca2+ Signaling Machinery in Early Animal and Fungal Evolution LETM1 MID1 HEL-S-11 MICA PMC7699248__F2 Wnt/Beta-catenin signaling pathway represses VDR expression NR1i1 CTNNB1 PMC7699248__F1 Mechanisms by which 1,25(OH)2D3 interferes the Wnt/Beta-catenin signaling pathway in human CRC cells NR1i1 TCF7L2 DKK1 GSK3B AXIN1 TCF4 CCND1 IL1B CTNNB1 PMC6857441__F7 Schematic overview of the pathways linking glucocorticoids and their precursors to their urine metabolites CYP21A2 HSD11B2 HSD11B1 PMC2681001__F1 Biosynthetic Pathway of Coenzyme Q10 COQ10B COQ10A PDSS1 COQ3 COQ2 COQ9 COA7 COQ6 COA5 PMC6857441__F3 Schematic overview of androgen biosynthesis POR HSD3B2 FDXR PAPSS2 CYP17A1 HSD11B2 HSD17B2 SULT2A1 HSD11B1 AKR1C2 PMC8273916__F8 Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor Alpha-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway GPR78 ATF4 PMC7552065__F2 HBV infection pathway SHB LHB PMC4335176__F2 Pathways leading to stimulation of extracellular-regulated kinase (ERK) and AKT phosphorylation by fluoxetine in astrocytes EGF HBEGF EGFR PMC7397420__F12 Demonstration of the putative mechanism of action of lithium in the NFKB signalling pathway BTRC TIRAP IRAK1 TRAF6 AK4 PMC3570922__F1 PI3K/AKT/GSK3/mTOR signaling PTEN MTOR CTNNB1 PMC8745344__F8A Multi-Omics Approach Profiling Metabolic Remodeling in Early Systolic Dysfunction and in Overt Systolic Heart Failure PLCD3 RYR2 PLN HEL-S-99n SIRT3 SLC27A1 LETM1 GAL CASQ2 HEL-S-5 AKAP12 CPT2 PMC8876702__F2 Reservoir of Persistent Human Papillomavirus Infection; Strategies for Elimination Using Anti-Viral Therapies PIEZO1 ARHA MTOR DNER RBPJ PMC7916890__F3 Crosstalk between mTOR signaling and PI3K/Akt pathway RHEB GRB10 PTEN IRS1 PMC7916890__F2 Amino acids and growth factors-mediated activation of the mTORC1 signaling SZT2 RHEB WDR59 NPRL2 C16orf35 FLCN MIOS SLC38A9 WDR24 PMC8283590__F2 Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update CXCL2 SRC PMC8283590__F1 Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update APC GSK3B LRP5 LRP6 PMC2192627__F1 Signaling mechanisms involved in lifespan regulation and the cellular response to genotoxic stress TSC2 TSC1 IGF1 ATM IGF1R MTOR SIRT1 IRS1 PMC8283590__F3 Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update LATS1 LATS2 BTRC AMOT TCF4 NF2 CTNNB1 PMC10941343__F9 Elucidating the anti-hypertensive mechanisms of Uncaria rhynchophylla-Alisma plantago-aquatica L: an integrated network pharmacology, cluster analysis, and molecular docking approach KLF2 BMP4 APP CNP ARHA SHE TNF PMC8432043__F1 Exploring the pathways to chronic lymphocytic leukemia ROR1 CD40 CXCL12 CXCL13 CCL3 CD44 CCL19 CCL21 PTCH2 PTCH1 CCR7 CXCR5 CCR4 SMO CCL4 VCAM1 CXCR4 CCR1 CCL1 PMC8269276__F1 Promising Treatment Options for Axial Spondyloarthritis: An Overview of Experimental Pharmacological Agents IFNG JAK3 EPO TPO JAK1 PMC4591212__F1 Altered modulation of the IL-8 signaling pathway in AH livers with MDBs GNG2 BAX GNAI1 LIMK2 GNG11 PMC11997178__F5 TRAF2 roles in cancer ROR1 CAP2 FZD5 MTOR CAP1 TRAF2 PMC7478739__F6 SOAT1 abrogates cholesterol feedback inhibition to promote mevalonate pathway dependency in PDAC HMGCR LDLR SOAT1 RHO PMC11997178__F2 TRAF2 role in the TNFR1 and TNFR2 signaling pathways RIPK3 STAT1 TRADD TAB3 RIPK1 BMX TRAF2 FADD PMC11997178__F3 TRAF2 role in the canonical and noncanonical Wnt signaling pathways ROR1 TCF4 TNIK TRAF2 CTNNB1 PMC5013308__F5 Pathway map of quantitative comparisons of metabolic proteins in RKO cell lines ACLY HEL107 HEL60 ASL HK3 CS HEL-S-51e SHMT1 SI HEL-S-32 PFKM GOT2 FH ACO2 DERA FASN HEL-S-70p RPE PAICS SDHB DLAT ALDOB HEL-S-68p HEL-S-162eP SUCLG2 DLD ENO1 PFKL HEL-S-87p PFAS PSPH PMC5013308__F4 Pathway map of quantitative comparisons of metabolic proteins in DLD-1 cell lines ACLY HEL107 HEL60 ASL GLS HK3 CS HEL-S-51e GLUD1 SHMT1 HEL-S-32 MDH2 HEL-S-26 PFKM GOT2 FH ACO2 HEL-S-133P HK2 DERA FASN LDHB HEL-S-70p RPE PGAM1 PAICS SDHB DLAT HEL-S-304 ALDOB PHGDH HEL-S-68p HEL-S-162eP SUCLG2 DLD ENO1 PSAT1 PFKL HEL-S-87p PFAS PSPH PMC2865574__F3 Wnt signaling is a complex pathway, believed to be involved in the regulation of divergent processes, including the maintenance of pluripotency and commitment to differentiation S100A4 CCND1 AXIN2 CTNNB1 PMC9604538__F2 Pathways for ATG16L1-mediated conjugation of LC3 to membranes during autophagy and LAP/CASM conjugation via the V-ATPase-ATG16L1 axis ATG3 ATG16L1 ATG12 WIPI2 UVRAG ATG14 ATG5 PMC11186359__F8 Schematic diagram showing how PM increases AREG-dependent glutamine metabolism and lung cancer proliferation EGFR AREG MTOR PMC5716183__F1 One-carbon metabolism, transmethylation reactions and DNA demethylation GADD45B HEL-S-61p MTR PMC3175556__F7 Schematic diagrams of the signal transduction in TCDD-induced MUC5AC gene expression and the conventional AhR pathway in the activation of CYP1A1 expression SP1 EGFR AHR PMC5215528__F1 ARE gene product interactome EGF CXCL12 CSF1 TGFB1 CCL3 IL3 MYC CCL2 CXCL8 CXCL3 CCNE1 IL16 FGF9 MMP2 CCND1 IL1B BIRC3 NOS2 IL10 JUN CSF2 CXCL2 PTGS2 MMP9 VEGFA IL6 TNF FOS FGF2 EIF4E PTHLH CDK2 BCL2 VCAM1 PMC8001969__F4 MTOR signaling pathway and its important regulatory functions are shown RHEB TSC1 SGK1 ULK1 TFEB TTI1 DEPTOR IRS1 PMC9214030__F2 From a Hetero- to a Methylotrophic Lifestyle: Flash Back on the Engineering Strategies to Create Synthetic Methanol-User Strains HEL107 RPE LTA HAL MTHFS GPT PMC7521558__F7 Schematic model summarizing the effects and signaling pathway of SRA in RCC CDH2 CD44 CD24 CDK6 SOX2 ABCG2 CCND1 CDK4 PMC2793058__F10 IFNG signaling pathway in retinal pigment epithelium STAT1 CFTR JAK1 PMC7747940__F2 Porphyromonas gingivalis: Immune subversion activities and role in periodontal dysbiosis TLR1 TIRAP CXCR4 MYD88 PMC8927572__F3 Proposed precision treatment strategies for MAPK pathway-mutated head and neck cancer ERBB3 MAPK1 HRAS EGFR BRAF PMC8927572__F2 Components of the MAPK pathway are mutated in both HNSCC (at somatic level) and in various RASopathies at germline level DUSP5 DUSP3 SPRED1 NF1 DUSP9 GRB2 DUSP7 PMC5861627__F3 Crosstalk between Shh pathway and others EGF PIK3CA BAD OTOR EGFR APC GSK3B LRP5 BRAF LRP6 KIT PTEN MTOR KRAS TGFBR1 CTNNB1 TGFBR2 KIF7 SUFU SHH SMO GHB2 PMC5861627__F1 Canonical activation of Shh pathway in vertebrates KIT SMO PMC8262573__F1 Translational Control is an Emerging Mechanism of Programmed Cell Death Ligand 1 (PD-L1)/Programmed Cell Death Protein 1 (PD-1) Regulation in Cancer IFNG STAT1 EIF5B EIF2A MYC PMC8761741__F2 Criminal of Adverse Pregnant Outcomes: A Perspective From Thyroid Hormone Disturbance Caused by SARS-CoV-2 TH TG TRH IL1B PMC6771534__F2 Evasion of the IFN‐I signaling pathway by HSV1 TBK1 CGAS TLR3 TLR9 IRF3 PMC9367940__F9 Taste Receptor Activation in Tracheal Brush Cells by Denatonium Modulates ENaC Channels via Ca2+, cAMP and ACh TRPM5 CFTR PMC2761115__F2 Gonad function and sexual differentiation DHH RSPO1 LHX9 WT1 INHBB SF1 EMX2 SOX9 SRY FST FGF9 WNT4 AMH PMC11662631__F8 Schematic show that the mechanism of hsa_circ_100791 promote the progression of allergic rhinitis TRIM13 IL33 IL4 IL2 TNF CAPRIN1 PMC4016907__F5 Both images were created using IPA SGK1 AKT3 MAPKAPK2 NEK2 GSK3B PTEN PRKCB RHEB PDK4 GSK3A PRKDC AURKB RPS6KB1 IKBKB PRKCA CHEK2 CHUK CAMK4 MDM2 PMC12000036__F2 Functions of TREM2 SOS1 SMAD2 MTOR ABCA1 CTNNB1 MYD88 TREM2 STAT1 ACAT1 ADFP DOK3 GRB2 SRC PMC4874901__F8 JNK mediates mouse liver injury through a novel Sab (SH3BP5) dependent pathway leading to inactivation of intramitochondrial Src DOK4 SRC TNF PMC8614257__F8 Equine Endometrosis Pathological Features: Are They Dependent on NFKB Signaling Pathway? CSA2 RELA HAS2 IL6 PMC12000036__F1 TREM2 signaling pathway TREM2 SYK ADAM17 PLCG2 CD33 ADAM10 DOK3 MTOR SRC PMC1420312__F5 Impact of SV40 ST on the Notch, Wnt, and Hedgehog Pathways CTNNB1 WNT5B BCL9 WT1 ANGPT1 GLG1 COX2 AK2 DKK1 WNT7A SHH MMP3 SMO FBN2 SOX7 OAS1 TSPAN7 GBP2 JUP MMP7 ANXA4 ID2 APC TLE4 FZD7 BOP1 NOTCH2 SPN CD44 HDAC1 PSAT1 LEF1 CLDN1 PMC7492727__F4 Proposed pathological mechanisms of MuSK autoantibodies at the NMJ ACHE MUSK ACR PMC8092973__F1 Simplified schematics of the mechanisms of replication fork restart upon replication stress WRNIP1 POLD3 PCNA BRCA2 PRIMPOL FANCA FANCD2 REV1 HLTF PALB2 MCM9 RAD52 RAD51 HROB POLI PARP1 BARD1 CHD4 RAD51C MCM7 SMARCAL1 SETD1A MRE11A BRCA1 POLK CDC45 MCM3 MCM5 MCM6 MCM2 ZRANB3 SLX4 POLN RADX FBXO18 PMC8840702__F1 Ferroptosis in cancer therapy: a novel approach to reversing drug resistance POR ATF3 LOX GPX4 LPCAT3 ARF6 FACL4 KIF20A LCN2 HEL-75 PMC4488672__F5 Hierarchical signaling pathway expression regulates regeneration WNT3A SHH IHH LEF1 CTNNB1 PMC10950698__F9 IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11 SOCS1 SLC3A2 IL13RA1 SLC7A11 PMC9605170__F4 Incorporation of Suppression of Tumorigenicity 2 into Random Survival Forests for Enhancing Prediction of Short-Term Prognosis in Community-ACQUIRED Pneumonia TRAF4 IL33 IRAK1 MYD88 PMC7920043__F1 Schema of “signaling” pathways for CS effects DKFZp781O1323 EGFR SMAD2 SMAD4 PMC4521272__F1 Polymorphism Near the Interleukin-28B Gene and Anti-Hepatitis C Viral Response TLR3 IFNAR1 IFNA4 IRF3 IRF7 TLR7 PMC9604538__F5 Interactions between pathogens and LAP/CASM ATG16L1 ATG12 ATG5 VAMP8 PMC8495264__F7 Thrombospondin-4 Is a Soluble Dermal Inflammatory Signal That Selectively Promotes Fibroblast Migration and Keratinocyte Proliferation for Skin Regeneration and Wound Healing DVL1 NKAIN1 ATP6V1G3 TRIM34 NR3C1 PCDHA1 NFIA CTNNB1 GNA15 FOXH1 TCF7L2 RICTOR DCDC2 ANGPTL7 BCL2 PMC3706794__F8 Proposed mechanism demonstrating the interplay of heme oxygenase 1 (HO-1) and the Wnt canonical pathway in the modulation of adipogenesis in mesenchymal stem cells (MSC)-derived adipocytes WNT10B CD36 GSK3B MSC CTNNB1 PMC6580798__F3 Proposed pathway for metabolic detoxication of AAI CRP CYP1A2 NQO1 CYP1A1 PMC8227208__F4 p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies CEBPA EGR1 N4BP1 ITCH EGFR NQO1 NGFR MDM2 SLU7 RPL26 YAP1 PMC8623382__F1 Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites CERK SMS SPHK2 SPHK1 PMC6689986__F1 Autophagy in the differentiation/function of osteoclast, osteoblast and osteocyte SMAD1 DKFZp781O1323 BMP2 ATG5 PMC7047114__F6 NFKB-pathway TLR4 IRAK1 TRAF6 GLRX IRAK4 MYD88 PMC8256831__F2 Adult Hippocampal Neurogenesis and Alzheimer's Disease: Novel Application of Mesenchymal Stem Cells and their Role in Hippocampal Neurogenesis IGF1 MSC BDNF PMC8631414__F5 Low-intensity extracorporeal shock wave therapy promotes recovery of sciatic nerve injury and the role of mechanical sensitive YAP/TAZ signaling pathway for nerve regeneration NGF GDNF BDNF PMC9074275__F6 Tetraspanin 7 promotes osteosarcoma cell invasion and metastasis by inducing EMT and activating the FAK-Src-Ras-ERK1/2 signaling pathway CDH2 SRC TSPAN7 PMC5329892__F3 WNK kinases in development and disease APC DCT OSR1 CTNNB1 PMC9389066__F2 Pyroptosis and inflammasomes in diabetic wound healing GSDMD NLRP3 GSDMC DFNA5 PMC12073904__F7 Mechanistic model of inflammation, mitochondrial dysfunction, and neuromuscular junction characteristics of HF and LF octogenarians CXADR NCAM2 ADM NMNAT1 FGF21 NEFL CDH15 ANGPTL4 AGRN F2R NADK GDF15 APP BDNF PMC9389066__F1 Pyroptosis and inflammasomes in diabetic wound healing NLRP1 NLRP3 AIM2 TNF PMC3622708__F8 Wnt3a/Beta-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signaling program LFNG MSGN1 HES7 NOTCH1 PMC3871231__F2 New and emerging HDAC inhibitors for cancer treatment HDAC3 HDAC1 SAP30 HDAC10 SAP18 TBL1X HDAC8 TBL1XR1 HDAC2 GPS2 HDAC6 PMC8401922__F3 AMPK and Its Downstream Signals in Pain Regulation MLST8 TSC2 CSF1 ULK1 CSF1R PMC11352841__F2 Bioactive compounds targeting NFKB signaling pathway to prevent inflammatory changes and mastitis TLR4 IRAK1 TRAF3 TRAF6 TRAF2 IRAK4 MYD88 PMC11352841__F1 Bacterial induced mastitis via activating TLR2/TLR4/NFKB signaling pathways in mammary gland cells TLR4 IRAK1 TRAF3 TRAF6 TRAF2 IRAK4 MYD88 PMC3965010__F1 Example of disease curation and visualization in Reactome G6PC2 CIC SLC37A4 CLC SLC37A1 PMC7339281__F2 METTL3 regulates cell proliferation ATAD2 IGF2BP1 DGCR8 EGFR AFF4 PTEN METTL3 MYC LEF1 CTNNB1 PMC6316632__F1 Simple central carbon network of the Xanthomonas oryzae pv. oryzae BXO43 strain TAC3 MAL CIT PMC7396579__F3 Glucocorticoid resistance (GCR) in sepsis TF SPHK1 GC TSC22D3 PCK1 PMC11352841__F3 Probiotic targetingTLR2/TLR4 /NFKB signaling pathway to prevent inflammatory changes and mastitis TLR4 IRAK1 TRAF3 TRAF6 TRAF2 IRAK4 MYD88 PMC4694690__F1 Clinical use of cobicistat as a pharmacoenhancer of human immunodeficiency virus therapy SLC22A4 SLC22A5 SLC47A1 PGP SLC47A2 SLC22A2 ABCG2 ABCC2 PMC5436210__F2 Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma AQP4 RPS6 KMT2C CASP2 GADD45G SOS1 SCD CARD11 SMAD2 FASN ATG2B MAFB NR0B2 ACACA SSB PURA HBEGF RUNX1 MTDH WEE1 ITK PPARGC1A SIRT1 PMC7339281__F3 METTL3 regulates cell apoptosis FGF14 HNRNPD TFEB SHH METTL3 ZNF750 PMC9231174__F3 Calcifediol for Use in Treatment of Respiratory Disease IFNG CYP27B1 TLR4 NOD2 HAMP MTOR FGF23 PMC5436210__F3 Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma IDE PDE3B AGO2 DICER1 FOXO4 SCD CIDEA INS SGCA TWEAK MEF2C LMNA PMC4194559__F1 Presents an overview of the Rho/Rho-associated protein kinases signaling pathway CDC42 ROCK2 ROCK1 MAP2 RHO PMC2858867__F1 ALPS – Ten Lessons from an International Workshop on a Genetic Disease of Apoptosis CASP8 CASP10 FADD PMC11989906__F4 Adipose Tissue Metabolism in Naturally Grazing Sheep at Different Growth Stages: Insights from mRNA and miRNA Profiles CAMKK2 SLC2A4 PFKP SCD FASN ACACA PMC7338975__F1 Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease IREB2 KEAP1 GPX4 GCLM LPCAT3 SLC7A11 FTH1 FTL STEAP3 GCLC HEL-S-102 ATG5 HEL-S-64p HEL-75 ADA PMC4140250__F1 Schematic view of the sphingolipid metabolism in S FEN1 ORM1 ORM2 PMC5415104__F9 Anti-microbial peptide TP359 attenuates inflammation in human lung cells infected with Pseudomonas aeruginosa via TLR5 and MAPK pathways TLR4 TLR5 MYD88 PMC5415376__F3 Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma ENO2 HK2 CS PDK3 PCK1 ADIJ PCK2 PGAM2 PDK4 GSK3A FBP1 MDH2 HEL-S-26 PMC7011072__F3 Curated interactions for HES1, NOTCH1, and TNFA genes using SIGNOR database PPARG IKBKE TNF CREB1 RBPJ NOTCH1 NR3C1 PMC8969013__F1 STING1 in Different Organelles: Location Dictates Function TBK1 CGAS MAVS IRF3 MITA PMC5713689__F3 Signal pathway of the immune inhibitory receptors.Notes: PD-1 crosslinks the TCR and recruits the SHP-2, which can dephosphorylate the ZAP-70 to prevent the SLP-76 and LAT from being phosphorylated ZAP70 TIGIT LAT PTEN FOXP3 MTOR TRAF6 LAG3 LCK PMC7020470__F6 Schematic diagram depicting MetAP2 implication in different pathways CDC42 BAD METAP2 MDM2 PMC7513295__F4 PPI network analysis CD80 SYK CD79A LTA PYCARD TNFAIP3 ULBP3 CTSH TXK TNLG8A JAK3 IKBKE PTPRC HLA-DPB1 RORA HAVCR2 SLAMF7 TEC STAT1 TFRC SP100 TLR4 CHUK OAS1 OAS2 BIRC3 HLA-DMB CD48 BATF CEACAM1 SAMSN1 PAG1 HLA-DQB1 ZNF155 SPN ZNF223 ZNF221 UNC93B1 HLA-DMA ZNF34 SASH3 LILRB4 GPR183 IL23R IL23A PMC7056469__F4 Oxidative stress are targets of antioxidant dietary compounds VIT OGG1 KEAP1 GCLC PMC10876307__F5 Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral Sinularia sandensis through the MAPKs Pathway on Oral Cancer Cells CA12 CA11 CA13 ARHA GRB2 CA9 CA14 PMC7355474__F8 Graphical representation to elaborate on the possible mechanism underlying antioxidative and anti-inflammatory potential of A3 against the p-MCAO-induced brain injury TLR4 MAF BCL2 PMC3974768__F8 Stem and Progenitor Cell Subsets Are Affected by JAK2 Signaling and Can Be Monitored by Flow Cytometry CD48 MPP2 MPP3 PMC12237660__F3 TREM2/TREM2+macrophages in MASH TREM2 SYK TLR4 IRAK1 TRAF6 MYD88 PMC12237660__F2 Targeting TREM2 signal pathway TREM2 SYK ADAM17 ADAM10 PMC12237660__F1 MASH (Metabolism and immune response) TREM2 FAS CCR2 PMC9006795__F1 Aneurysmal subarachnoid haemorrhage—cerebral vasospasm and prophylactic ibuprofen: a randomised controlled pilot trial protocol COX1 COX2 KY C2 RHO PMC5118702__F5 Molecular and biological pathway interaction map analysis of altered proteins from the CCI samples (1 vs STXBP1 HEL-S-99n ENO1 PMC6943653__F1 Scheme of the insulin/IGF-1 signaling pathway (IIS) in C SGK1 PMC4007207__F9 Model of the role of an epidermal barrier defect in tumour protection HRAS TSLP RAE1 PMC6030864__F1 Pathway relationship network MAK MAL MTOR PMC8234459__F3 Paradoxical Roles of Desmosomal Components in Head and Neck Cancer MMP7 EGF KLK5 SNAI2 EGFR PKP1 DSG1 DSG2 PKP3 DSG3 DSC1 DSC2 CTNNB1 ERBIN CCND1 PMC7878744__F1 Renal metabolism and hypertension GLS HEL-S-5 CS PMC3026934__F2 Signaling pathway induced by Dectin-1 SYK BCL10 SRC CARD9 PMC7023692__F3 Representative diagram of circRNA mediated ceRNA network and oncogene signaling pathways MOV10 STAT3 DICER1 ITCH SHKBP1 ZIC4 U2AF1 FZD7 TCF2 FOXP2 WNT7B CTNNB1 PMC3140958__F6 Protein interaction maps of the defined ratio clusters, (A) [G1_S]#3 and (B) [G1_S]#2 FUS GGA2 PMC4981436__F4 The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine PPARG RARA NR1C1 NR1B3 RARB RXRA NR1A2 THRA PMC3256462__F1 Basic signaling pathways and relevant targets together with their inhibitors associated with endocrine resistance Estrogen receptor alpha (ER) and the growth factors (esp EGF ADAM17 SRC PMC6369349__F1 Molecular signaling pathway of TNFR2 MAP3K7IP1 TRADD TAB3 TRAF1 TRAF3 TNF TRAF2 FADD PMC4713888__F1 Immune evasion mechanisms seen in acute leukemia.Multiple immune pathways and functions are targeted by acute leukemia STAT3 MICA LAG3 PMC3499976__F1 Wnt transduction pathways and their functions during synapse development, function and plasticity MUSK MAP1B PSD APC GSK3B MAP2 RHO CTNNB1 PMC8678454__F7 Global Profiling of N-Glycoproteins and N-Glycans in the Diatom Phaeodactylum tricornutum TH ALG12 INS PMC8636065__F7 Hippocampal Transcriptome-Wide Association Study Reveals Correlations Between Impaired Glutamatergic Synapse Pathway and Age-Related Hearing Loss in BXD-Recombinant Inbred Mice GRM3 SHANK3 GRIA3 GRIA2 GRM8 GLS GRIK1 GRIA4 GRM2 MAPK3 PMC5814228__F6 Deciphering microRNA targets in pancreatic cancer using miRComb R package ADAM17 DTX4 DTX3L NUMB EP300 HES1 HES5 PMC6089339__F7 Summary of the location pattern of CFP (blue), YFP (yellow), neuronal (PV) and activity markers (Arc) in the hippocampus CA3 FH CFP GC PC HEL-S-11 ARC BDNF PMC5855671__F2 Integrins act as “double agents” during Helicobacter pylori infection in the stomach, serving to potentiate bacterial pathogenicity while also aiding in the immune response ASB1 EGFR HEL-S-28 AVP PMC11234204__F5 Regulatory factors involved in sensitivity and resistance to ferroptosis in HCC patients treated with sorafenib CISD2 STAT3 SLC3A2 DAZAP1 GPX4 SCD MCL1 FASN FACL4 SLC7A11 C8orf76 ZNF263 ATF4 LCN2 NF2 PMC7672575__F5 Signaling pathways of MD-2/TLR4 axis that lead to stimulating the immune responses TBK1 TIRAP TAB3 MAL IRAK1 IRF3 IRF7 SOCS3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR4 IL1B PMC4701050__F3 Origin and in vitro generation of eCPCs SHF MESP1 ISL1 DKK1 PDGFA NODAL KDR Meflin GATA4 MEF2C PMC7672575__F7 Potential antiviral mechanisms of action for honey contain caffeic acid, CAPE, galangin, and chrysin against SARS-CoV-2 GAL HEL-S-69p ACE2 PMC5882022__F1 The regulatory roles of different sirtuins in the reprogramming of human skin fibroblasts to generate induced pluripotent stem cells STAT3 SIRT3 SIRT7 SIRT4 LIF SIRT5 SIRT2 SIRT1 NMNAT3 SIRT6 PMC7716408__F6 Proposed molecular mechanisms for PA regulating ferroptosis in IRI-AKI SLC3A2 GPX4 SLC7A11 PMC11234204__F1 Canonical mechanism of ferroptosis TF SLC3A2 ACSL3 GPX4 LPCAT3 SLC38A1 FACL4 SLC7A11 DHODH STEAP3 ALOX15 GLS2 HEL-75 PMC11234204__F4 Metabolic dysregulation mediates ferroptosis in HCC SLC3A2 HCAR1 TMEM147 PNO1 STAT2 GPX4 SCD BCAT2 DHCR7 SLC7A11 SLC27A4 PMC3243079__F2 Non-genomic ERA pathway JUN SRC FOS PMC2896911__F8 Regulatory network that links the activities of an ensemble of transcriptional regulators, signaling components and survival factors in developing B cells into a common pathway STAT3 CD79B SYK CD79A PTEN RUNX2 HOXA7 SIRT3 CTCF PAX5 RAG1 CEBPB SOX4 NOTCH1 ETS2 EGR1 ID2 E2F2 BLNK EZH2 CD19 IRF4 IRF8 ERG BCL11A GATA3 RUNX3 ID3 BLK FOXO1 VPREB3 VPREB1 POU2F1 BCL2 HDAC7 CXCR4 LEF1 BCL6 PMC7766288__F2 Mechanisms of several lncRNAs in CC PCNA BLACAT1 EZH2 PTEN MTOR CTNNB1 PMC11234204__F3 NRF2 is involved in preventing lipid peroxidation and ferroptosis in HCC CEP290 SLC3A2 FNDC5 CPLX2 KEAP1 ADIPOR1 IGF2BP3 GPX4 SLC7A11 QSCN6 SLC27A5 FTH1 NQO1 PBR GSTZ1 SIRT1 HEL-75 PMC5994595__F3 Excitatory toxicity model of methamphetamine NUPR1 ATF4 PMC5506270__F1 T cell signaling, activation and antigen recognition APC PMC7897342__F2 Role of the ATF/CREB family in the pathway involved in hepatic lipid metabolism APOA2 TG FAS APOA4 NR1C1 SPHK2 FGF21 CREBZF ATF4 EIF2A CPT1A SIRT1 PMC3711318__F10 Proposed model for activation of the ATR/Chk1 signaling pathway and G2/M phase cell cycle arrest induced by HNE CDC2 CCNB1 PMC8080578__F4 New paradigm for the regulation of STAT2 protein in melanoma formation FBXW7 GSK3A STAT2 GSK3B PMC3856238__F6 Global Proteomics and Pathway Analysis of Pressure-overload Induced Heart Failure and Its Attenuation by Mitochondrial Targeted Peptides ACLY TRO NDUFB11 NDUFV2 NDUFA13 SDHD SDHA HEL-S-66p NDUFB10 SDHB NDUFB3 OGDHL MDH2 PPA2 ADA PMC4207979__F1 One-carbon metabolism is required for the synthesis of purines, thymidylate (dTMP), and methionine MTHFD2 HEL-S-182mP DHFR TYMS HEL-S-51e PMC3515668__F1 Schematic representation of the potential disruption of the hepatic GHR-JAK2-STAT5b signal transduction pathway by TCDD AHR SOCS3 GHR PMC6082850__F8 Antidepressant and anxiolytic mechanism of acupuncture in a PTSD rat model MTOR SYN1 EIF4E PMC7860207__F2 Significantly enriched Cell Cycle pathway from genes with high DE prior probabilities TGFB1 CDC20 PCNA ORC6 CDC6 STAG1 SMC3 SMAD2 GSK3B SFN SMAD4 ORC1L CCNA2 MYC SKP2 PLK1 CCNH RB1 CDKN2A CDK7 E2F4 TTK ATM HEL-S-1 MDM2 CCNB1 CCND1 CDK4 CDC2 DBF4 TFDP1 SMC1A ORC3 ORC2 HDAC1 RBL1 CCNE2 CDKN1A CDC45 CHEK1 SKP1 CDK2 CDC27 MCM2 GADD45A PMC6828713__F1 Otub1-mediated regulation of the IL-15 signaling pathway IL15 MTOR JAK1 PMC8499812__F6 DeepDRIM: a deep neural network to reconstruct cell-type-specific gene regulatory network using single-cell RNA-seq data MAX TF ADAR AKNA SLA NFATC2 GPX4 VCP MEF2C MRPL57 SP100 LPXN HEL-S-108 EIF4A1 ZNFX1 CREB1 IKZF3 PSMB3 E2F2 DUT SNX3 RPS27L PTBP1 CASP3 ZNF683 ZNF207 ARF4 HMGB2 ADA PMC6521935__F7 Mechanism of salidroside-induced apoptosis, cell cycle arrest and suppressed invasion of osteosarcoma cells via inhibition of the JAK2/STAT3 signaling pathway STAT3 BAX CCND1 PMC8698620__F8 Murine Neonatal Oxidant Lung Injury: NRF2-Dependent Predisposition to Adulthood Respiratory Viral Infection and Protection by Maternal Antioxidant CD40 ARHGAP22 GCM1 MAFG NCAPG TCN2 BBC3 RB1 MORC3 STK10 AKAP11 WAS PTCHD4 RGS14 PSMB3 UTP3 JUNB NBN TNF MVK SST LTB CCL24 KIF21A TTC32 FOXL1 KLF17 GAREM2 LCN2 EGR2 FXYD4 CCDC61 KLC2 GRIA3 RRAD ABL2 SFN CS INSIG1 GRHL3 PPFIBP1 MSC TIFA MX1 LEO1 FAM83D CDCA2 ENDOD1 IL12A MAPRE3 MAL SUGP2 RNMT ARID3A MKX MPZL2 MAFF SCUBE1 NEK3 RRAS PMC7387650__F3 Regulation on the suppressive nature of MDSCs by subset composition and the tumor microenvironment POLI ARG1 FOXP3 MTOR PMC5402913__F1 Profile of romosozumab and its potential in the management of osteoporosis GSK3B LRP5 LRP6 TEF CTNNB1 PMC3696710__F1 Constitutive components and the transduced mechanisms of Hh signaling pathway SUFU GSK3B SMO GAS1 GLI3 PMC8001022__F2 RAGE structure and signaling pathway HMGB1 TIRAP C2 TLR9 TLR7 MYD88 PMC11021430__F5 Representative scheme illustrating regulatory mechanisms of PTEN in BMSCs ATR IGF1 DLK2 DLL4 APC GSK3B MAF ATM PTEN MDM2 MTOR DLL3 PMC11021430__F7 Representative scheme illustrating regulatory mechanisms of PTEN in HSCFs, SCs, ISCs and SSCs EGFR KIT PTEN ATG10 ATG3 MAML1 ATG12 FOXO1 BMP2 KL SRC ATG5 RET PMC11021430__F6 Representative scheme illustrating regulatory mechanisms of PTEN in RPCs KLF4 EGR1 SMAD2 PTEN MTOR PAX6 IRS1 FGF2 CTNNB1 RHEB TSC2 SAG TSC1 IGF1 SUFU PTCH1 SHH SMO HES1 HES5 PMC3545532__F2 Model depicting the canonical Nrf2 stress response pathway in each of the different phases: basal, preinduction, induction, postinduction BACH1 FYN GCLC GSK3B PTEN PMC5977125__F1 Overview of the cap-dependent translation initiation ELF1 SUI1 ELF2 EIF5 MTOR ELF5 ELF3 EIF4E PMC9425624__F2 Mast Cells in the Pathogenesis of Pruritus in Mastocytosis NGF ITCH CALCRL RAMP1 MRGPRX2 PMC1995566__F7 Oxidative stress initiates a cascade of reactions leading to cell death via one or more sequences of molecular events CASP9 BAD CASP3 PMC6049067__F6 MiR‐26a‐5p as a novel HB repressor AURKA RAN LIN28B PMC4081859__F2A Complement regulation of T cell immunity APC PMC8050425__F5 Can1 and Mup1 endocytic pathways triggered by distinct signals MCC PMC7215397__F3A Prenatal S-Adenosine Methionine (SAMe) Induces Changes in Gene Expression in the Brain of Newborn Mice That Are Prevented by Co-Administration of Valproic Acid (VPA) HEL114 PXN KDR GRB2 PMC9120625__F6 Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression RB1 GSK3B BDNF CTNNB1 PMC6206761__F2 Interconnected responsible pathways to cause amyloid and tau accumulation TREM2 CLU CD33 CD2AP APOE BIN1 EPHA1 CR1 PICALM PMC6104488__F2 Schematic illustration of the PTEN regulated PI3K-AKT-mTOR signaling pathways in CNS axon regeneration GSK3B PTEN PMC8469189__F2 Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry FAS MSC IL6 PMC11563972__F3 Curcumin in the treatment of Parkinson’s disease (PD) KEAP1 TLR4 CTNNB1 PMC11588630__F1 AIM2 inflammasome activation signaling pathway GBP5 TBK1 CGAS GSDMD STAT2 AIM2 IRF3 GBP1 TYK2 GBP2 PMC3936406__F1 Molecular signaling pathways mediated by MET receptor tyrosine kinase in neurons CDC42 CD44 STAT3 HGF AXL CRKL RHO GRB2 MTOR SRC RAC1 PMC7809845__F4 Prolactin signaling pathway (KEGG ID: hsa04917) PRLR TH AKT3 GSK3B SHC2 KRAS FOS CCND2 PRL RELA GCK GRB2 CISH SRC PMC12178017__F6 EGb761 suppressed vascular dementia via modulating Wnt/Beta-catenin signaling pathway-induced apoptosis and autophagy in hippocampal neuronal cells DKK1 IRGM TFEB SQSTM1 PMC2045624__F1 OX40 signaling directly triggers the antitumor effects of NKT cells CD40 CD80 CD1D PMC5221490__F6 Intrinsic and extrinsic factors used during vertebrate lens development SMAD1 FOXE3 DKFZp781O1323 APC LRP5 SOX2 SMAD4 LRP6 MTOR PAX6 RBPJ CTNNB1 PROX1 ACVR1 SOX1 PITX3 GRB2 HES1 PMC4613668__F2 MAPK/JNK signalling: a potential autophagy regulation pathway ATG12 AMBRA1 BNIP3 ATG5 ULK2 RAC1 PMC4148035__F6 A negative feedback role of miR-326 in the Shh signaling pathway SHH SMO PMC7584566__F5 Schemes depicting hormonal axes involving insulin-producing cells (IPCs) in adult flies PDF APC PMC8222562__F1 SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end‐joining RAD50 RAD51 MRE11A PMC11588630__F4 Regulatory mechanism of AIM2 in tumor cell proliferation and migration STAT3 AIM2 MTOR PMC11588630__F3 Regulatory mechanism of AIM2 in inflammatory response NLRC4 CXCR3 AIM2 IRF1 MTOR CXCL10 MYC PMC11588630__F2 Other signaling pathways of AIM2 RIPK3 IL1R1 CGAS GSDMD NLRP3 MLKL AIM2 IRF3 IRF4 IL23R FADD PMC6150497__F3 Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator KLF4 RAB10 TNFRSF1A RCOR1 PTEN SOCS3 ATXN2 IRS1 RICTOR TSC1 GSK3A GYS1 TBC1D4 PMC7600282__F4 Target points of the dietary compounds on mitochondrial dynamics and mitogenesis, with a particular focus on mitophagy PINK1 FIS1 MTOR FUNDC1 TFAM SIRT3 ATG3 SMURF1 FOXO1 PARL FOXO3A TFEB NRF1 PMC6876298__F2 Dysregulation of the complement cascade in C3 glomerulopathy CD59 FH HEL-S-62p C1S CR2 CD46 CS C4A C4B_2 CR1 PMC2993855__F2 Pathways correcting DNA polymerase errors MSH6 MLH3 MSH2 MSH3 PMS2 PMC4511812__F1 Hematologic malignancies: at the forefront of immunotherapeutic innovation HMGB1 APC IL7R IL7 PMC6057898__F3 Interplay between melatonin and clock genes in joint during OA ACAN SOX9 PER2 PER1 NFIL3 SIRT1 COL2A1 IL1B PMC7280868__F1 Canonical autophagy pathway WIPI1 ATG10 CSA2 ATG16L1 ATG12 WIPI2 ATG5 PMC11855613__F1 Diagrams summing up the pathogenetic pathways relevant to BBB disruption in TBE and discussed in the paper MMP7 MMP3 MIF MMP9 TNF PMC8276315__F8 Small-molecule modulators of INAVA cytosolic condensate and cell–cell junction assemblies NOD2 MTOR TRAF6 INAVA PMC3405863__F4 EGFR pathway in Drosophila STAR EGFR GRB2 PMC2721689__F1 Structural and functional modules in RNA interference RNASE3 DGCR8 DROSHA PMC3405863__F5 Segmentation clock oscillator FRS2 DKK1 APC NRARP LRP6 LFNG GRB2 HES7 HES1 CTNNB1 HES5 PMC3513309__F3 Gene Expression Profile of Peripheral Blood Lymphocytes from Renal Cell Carcinoma Patients Treated with IL-2, InterferonA and Dendritic Cell Vaccine CDC42 TEC CD79B ITK CD19 PTEN GRB2 MTOR RAC1 LCK PMC8799543__F2 Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury CD44 CD74 NLRP3 RPS13 ACKR3 MIF IL8RB IL1B HEL-S-44 PMC3970144__F6 HCV assembly involves a concerted action of all viral proteins and hijacks the host lipoprotein synthesis pathway DGAT1 APOE APOB PMC7365859__F1 Legend: A schematic view of the involvement of zinc in various signaling pathways TANK MYC PMC6704288__F5 Proposed model of the combined effect of ROR1 inhibition and erlotinib treatment in non-small cell lung cancer cell lines via inhibition of the AKT/mTOR signaling pathway ROR1 EGFR PTEN MTOR IRS1 PMC6115979__F3 TRPM7 kinase in T cell signalling and transcriptional regulation TF STAT3 TRPM7 RORC SMAD2 SMAD4 ITGAE IL6R TGFBR1 PMC6932917__F10 RXFP3 in DNA damage response and repair GIT2 RAD51 RXFP3 MRE11A BRCA1 H2AX PRKDC RLN3 BRCA2 ATM MDC1 PARP1 PMC3513309__F4 Gene Expression Profile of Peripheral Blood Lymphocytes from Renal Cell Carcinoma Patients Treated with IL-2, InterferonA and Dendritic Cell Vaccine CDC42 CD40 FLT3 ZAP70 SYK CD80 BAD EPO MTOR CTLA4 EIF4E RBX1 BTK BCR CSK MDM2 GRB2 GATA4 GAB2 PMC3103499__F3 Computational Identification of Transcriptional Regulators in Human Endotoxemia ACLY TNFRSF10C FAS CXCL2 GLO1 TNF MZF1 CSF3R INHBB IRAK3 HEL-S-32 MDH2 CCL20 CASP10 IL1B PMC8604044__F2 Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder HMGCR SQLE PMC5828651__F5 RNA-editing regulated genes in LUAD are enriched in apoptosis and innate immune-related genes FAS MAVS DFFA ELF2 TNF PMC7870930__F3 Progress in understanding the role of lncRNA in programmed cell death RIPK3 MLKL RIPK1 TNF PMC6307844__F1 Pathways participate in tumourigenesis of CCA APC GSK3B CTNNB1 PMC3809585__F3 TAM-regulated cycle of inflammation in dendritic cells AXL TLR3 TLR4 TRAF3 TRAF6 PMC7904626__F1 Biosynthetic pathway of oxetanocin-A (1) CBL FES PMC3809585__F2 TAM receptor signaling pathways SOCS1 CRK STAT1 GRB2 PMC4977063__F7 Model deciphering the signalling pathway hijacked by EspT leading to induction of inflammatory responses in macrophages CDC42 IL16 RAC1 IL1B PMC9522918__F4 Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma TH PMC11351628__F1 PPAR targets and contributing factors in MASLD/MASH LPL APOC2 APOC3 EHHADH FAS CD36 APOE FABP4 SLC27A1 TG NR1C1 MTTP DGAT2 MOGAT1 TFEB PMC8261853__F2 Host Modulation and Treatment of Periodontal Disease RORC GSK3B JAK1 TNF IL6R CTNNB1 PMC4174666__F4 Generation of a biological network of genes related to the upstream regulator IRF2 STAT3 NMI HELZ2 SERPINE2 IRF2 IRF1 NAMPT HAMP IFIT2 VCAM1 CCNC PF4 PMC6794554__F1 Wnt signaling with two intersecting networks: Canonical Wnt (or Beta-catenin-dependent) and non-canonical Wnt (or Beta-catenin-independent) pathways CDC42 ROR1 APC ROR2 GSK3B LRP5 CDK14 LRP6 ATF2 ARHA RAC1 CTNNB1 PMC7515827__F2 Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications ACLY CDH2 NNMT FH PIG59 HMGCR EGFR DPYD ASNS FAAH HEL-S-26 TWIST1 PMC6927537__F2 Kinase alterations and signaling pathways dysregulated in Ph-like ALL FLT3 ABL2 CRKL JAK3 EPO NTRK3 MTOR INS KRAS POR IL2RB ETV6 PDGFRA FGFR1 NRAS LYN JAK1 TYK2 CRLF2 CSF1R PMC7766727__F3 PI3K/AKT signaling pathway with plant-based inhibitors (created by BioRender.com) RHEB TSC2 BAD FAS TSC1 APC LRP5 LRP6 PTEN CTNNB1 FADD PMC8507398__F10 Molecular biology of autoinflammatory diseases TRADD TIRAP OTULIN IRAK1 TRAF6 IRAK4 MYD88 SHARPIN RIPK2 MAP3K7IP1 NOD2 TRAF5 RIPK1 TRAF2 CYLD PMC7084529__F11 Altered sphingolipid and gene transcript levels in ASAH1KD SH-SY5Y cells ASAH2 CERS5 CERK CERS1 SGMS1 SGPP1 CERS2 DEGS1 SMPD1 KDSR ACER3 SMPD2 PMC12144744__F4 Antitumour mechanisms of statins TBK1 IPP HMGCR GC IL33 IRF3 RHO CTNNB1 PMC12144744__F1 Mechanism linking dyslipidaemia and gastric cancer STAT3 CCL24 VEGFC CCL22 CD36 GC BCL2 VCAM1 SRC CCL17 PMC4842340__F2 Involvement of the prohibitin (PHB/PHB1) in granulosa cell (GCs) survival and differentiation functions BAX STAR OPA1 BCL2 PMC8887676__F7 Therapeutic potential of the PI3K/AKT/mTOR axis for the management of AD and cancer CDK5 CDK2 MTOR CCND1 PMC3675076__F5 Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy HDAC1 SMO PMC5003605__F1 Metabolic pathways and genes involved in the utilization of nonfermentable carbons GID8 F2 FBP1 MDH2 PCK1 PMC4730127__F3 Targeting of the genes and pathways for stem cell maintenance by miR-200 family miRNAs BMI1 MAML3 ZEB2 MAML2 CTNNB1 PMC3590494__F4 Significant molecular network of combination therapy related metabolites PTER SKI PMC7303382__F8 Neuroactive ligand–receptor interaction pathway LEP SCTR TACR2 LEPR TRPV1 FSHR LPA MLNR APELA GHSR PRL PTGFR GIPR PMC6423002__F1 AMPK/Ulk1-dependent autophagy as a key mTOR regulator in the context of cell pluripotency ULK1 SOX2 MTOR SOX21 PMC11894577__F8 KEGG website to retrieve a map of the key pathways of CE action in ovarian cancer SYK MYB BAD RBL2 PTEN CD19 MTOR RAC1 EIF4E RHEB TSC2 BCR TLR4 RXRA MDM2 GRB2 PMC7063117__F3 Regulatory role of miRNAs in OP-associated pathways CBL SCD EGFR APC GSK3B LRP5 LRP6 NFATC1 ERG TRAF6 RUNX2 CTNNB1 PMC8035314__F3 Signaling via the IR and IGF-1R RHEB TSC2 BAD TSC1 PTEN GRB2 PMC8151052__F1 Targeting the Fibroblast Growth Factor Receptor (FGFR) Family in Lung Cancer CBL FRS2 GRB2 PMC8035314__F2 Functional outcomes of the IR/IGF-1R/IRS pathway in normal and breast cancer settings IGF1 SHBG IGF1R IGF2 PMC3590501__F6 Proposed mechanism for the protective effects of carvacrol against hepatic steatosis in mice FAS HMGCR CD36 CD14 IRF3 DHCR7 FDPS MTOR MYD88 PMC9618889__F6 Major pathways involved in macrophage polarization in cancer STAT3 ANXA1 PTEN GRB2 SRC PMC7407119__F2 The antioxidative landscape in the cell, and the corresponding modulators of key players TXN KEAP1 SFN HEL-S-64p HEL-75 PMC6509080__F2 Mechanistic pathways underlying reverse cholesterol transport from macrophages to liver TG ABCG1 APOE LDLR PLTP ABCA1 PMC7407119__F1 The major sources of reactive oxygen species (ROS) in the cell and the corresponding inhibitors of those sites ERO1A NOX4 DHODH PMC5854933__F1 WNT pathway DACT1 TMEM88 APC GSK3B FZD7 LRP5 LRP6 HUWE1 CTNNB1 CDX2 DKK1 WWOX TNIK PMC7299226__F6 Metabolic pathway showing lysoPL (lysophosphospholipids)/lysoPA (lysophosphatidic acid) regulatory genes that are significantly altered by ANRIL knockdown in HEK cells.Genes that metabolize these lipids are shown PLPPR2 PLBD1 ACSL6 LPCAT2 LPCAT3 PLA2G4C PNPLA2 DGKA PLPP2 PLPP1 PC LPCAT1 ENPP2 PLA2G7 PMC5877728__F1 Overview of the stress-activated protein kinase (SAPK) pathway ZAP70 MAP3K7IP1 TNIK PMC4005386__F2 Signaling networks for brain, lung, and bone metastases of breast cancer CDC42 AKAP8L HEL113 RPS14 FBL WIPF1 KHDRBS1 FLNA IKBKG RPS27 MDM4 FYN SEC16A HEL-S-1 KDR MDM2 HDAC2 ACTG1 RPS23 NCK1 RAC1 HDAC1 CCT8 MAP3K1 PHGDH NFKB1 RELA IKBKB PARD6B RPL4 EP300 GRB2 SUV39H1 REL CDC25B NFKBIB RET YWHAZ PMC7738904__F1 Essentials of TGFB signaling pathway SMAD2 SMAD4 PMC2854249__F2 Mammalian autophagy: core molecular machinery and signaling regulation RHEB TSC2 BAD TSC1 PTEN GRB2 IRS1 PMC4960093__F3 General summary of altered mitochondrial functions in cancer cell life and death BAX BCL2 HIF1A MYC PMC3495133__F1 Schematic of the desaturation and elongation biosynthetic pathway of essential dietary fatty acids to longer chain fats GLA FADS2 FADS1 PMC2854249__F1 Mammalian autophagy: core molecular machinery and signaling regulation TP53INP2 ULK1 VMP1 UVRAG AMBRA1 PMC4699388__F7 Overexpression of E2F-2 abolishes the PPP-mediated inhibition of terminal differentiation in Gata1S310A erythroid cells ex vivo IGF1 ERAF EPO IGF1R ALAS2 ING1 PMC7946848__F3 Possible roles of circRNAs in SLE RNASEL EIF2A PMC5869074__F1 Cross-talk between protein synthesis, energy metabolism and autophagy in cancer ULK1 PTEN IRS1 EIF4E ATG101 RHEB TSC2 EEF2K TSC1 ATG12 EEF2 ATF4 EIF2A PMC11774878__F4 Functions of non-coding RNAs that target ferroptosis and EMT in TNBC metastasis STAT3 NR3C2 RHOT1 GPX4 USF1 SLC7A11 PMC8983758__F2 Feedlot diets containing different starch levels and additives change the cecal proteome involved in cattle’s energy metabolism and inflammatory response ENO2 SLC2A4 HK3 PCK1 PC HEL-S-32 MDH2 GCK PFKM GOT2 HEL-S-133P HK2 HEL-S-278 SLC2A2 SLC2A3 LDHB MPC1 MPC2 PDHX PGAM1 DLAT PDHA1 PGAM2 ALDOB ENO3 FBP2 HEL-S-68p PFKP HEL-S-162eP HEL-S-49 FBP1 DLD ENO1 PDHA2 PFKL HEL-S-87p PMC11774878__F3 Crosstalk between ferroptosis and EMT in TNBC metastasis LATS1 CDH2 MTHFD2 LATS2 TFRC GPX4 FACL4 NF2 TWIST1 PMC1857267__F2 Altered macrophage differentiation and immune dysfunction in tumor development NOS2 JAK3 ARG1 CEBPB PMC8036852__F3 Brucella can inhibit the secretion of IL-2 by antigen presenting cells, and then prevent natural killer cells (NK) from secreting inflammatory factors such as IFNG and TNFA CD80 APC PMC11774878__F2 EMT in TNBC metastasis YTHDC1 FOXM1 RBMS3 GSK3B PRRX1 KIF23 PMC8482137__F4 Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups UGT1A4 UGT2A2 DIO1 UGT1A3 UGT2A1 UGT1A9 UGT1A5 SULT1A2 B3GAT3 B4GAT1 UGT2B10 PMC8482137__F3 Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups JUN PIK3R1 PTEN MAP2K1 MAP2 MYC INS CXCL8 CCND1 PMC3962195__F1 Biological processes and genes implicated in the Parkinson's disease HTRA2 CASP9 LRRK2 KY CASP3 SNCA PMC2907698__F4 An example of combined analysis of three identified regulatory modules MAX BAX JUN JUND BAD FAS PCNA NFATC2 EGFR BRAF DUSP4 PTEN ATF2 RHO C13orf34 CALM1 PRKX BCL2 GRB2 PMC7279161__F4 Comparison of Nrf1 and sterol regulatory element-binding protein (SREBP) activation pathway MAF NGLY1 NRF1 DDI2 PMC3972652__F1 Biosynthesis pathway for gangliosides GATC GAL ST8SIA1 B3GALT4 PMC5424241__F5 Leukocyte extravasation signaling pathway MMP16 VASP PXN NCF2 TXK CD99 NCF1 PRKCB MMP11 CTNNB1 JAM2 TEC BTK PRKCE MMP2 ITK UNK MMP7 ARHH ITGA4 NCF4 MMP9 HEL114 CD44 CRK CLDN11 FER MVP MGAM CXCR4 PMC3731064__F2 Chromatin and the genome integrity network DNA2 BLM RBBP8 PMC8753987__F6 Top-Down Enrichment Strategy to Co-cultivate Lactic Acid and Lignocellulolytic Bacteria From the Megathyrsus maximus Phyllosphere RPE XK PDC PMC12179905__F1 Pathways of apoptosis BAX FAS ATF4 TNF PMC8148105__F1 IDARE2—Simultaneous Visualisation of Multiomics Data in Cytoscape C6 PPARG AGPAT5 CEBPA GPAM HEL-S-62p C2 PAH PMC12179905__F2 Common signaling pathways affecting apoptosis: Phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway and wnt/Beta-catenin signaling pathway BAX APC GSK3B MTOR CTNNB1 PMC3433899__F3 Single gene and protein network generated by Approach 3 (Network 1) that demonstrated significance as a clinical relapse predictor following a stringent permutation based test ACLY MYLK FTH1 CRABP2 MVP CNN2 HEL-S-102 COL14A1 C4B_2 DCN PARP1 PMC3977653__F1 At Loose Ends: Resecting a Double-Strand Break RAD51 DNA2 PMC3406577__F6 Restoration of cell death by ABT-737 in cancer cells that overexpress Bcl-2 and caspase activity is blocked HTRA2 PMC6007953__F1 XIAP regulates apoptotic and inflammatory signaling pathways TRADD NOD2 TNF TRAF2 FADD PMC8567306__F5 Clinical translation of immunomodulatory therapeutics JAK3 IL2 JAK1 PMC7567935__F15 Pre-treatment of rats with melatonin (10 mg/kg bw) prior to ISO treatment (25 mg/kg bw) prevented occurrence of myocardial infarction and averted mitochondrial dysfunction caused by ISO mediated oxidative stress PGC SIRT3 LPO SIRT1 PMC5425951__F2 Ingenuity Pathway Analysis network showing the relationships between several assayed genes (emphasized with black arrows) LILRB4 DMBT1 CLEC10A CTSZ TYK2 HLA-A PMC10933033__F3 Pro-inflammatory cytokine expression by interleukin receptors via STAT and IRF transcription factors CD40 STAT1 IRF3 IRF4 PMC10933033__F2 TOLLIP-mediated regulation of IL-1R signaling IRAK1 TRAF6 PMC5149546__F7 Putative triterpenoid saponins biosynthesis pathway in A IPP IDI1 PMC6291243__F2 Biosynthesis of the ADR-GlyU disaccharide core 17a LIPN LIPM LIPK PMC4864225__F3 Hypothesis on skeletal muscle adiponectin resistance in chronic heart failure ADIPOR1 FOXO1 SIRT1 PMC10933033__F4 Adaptor protein SLAP-2 regulates CSF1R-mediated differentiation and survival of macrophages GRB2 GAB2 CSF1R PMC2997336__F1 Model illustrating the signaling pathways activated by optimal DA and hyperdopamine CDK5 GSK3B CTNNB1 PMC8476809__F2 Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights From Other Cancers BAX PINK1 FIS1 OPA1 ULK1 SMAD2 MTOR TNF PAX7 TSC2 TSC1 IGF1 ATG12 MFN2 ATF4 EIF2A ATG5 PMC10933033__F1 Adaptor proteins mediating the signaling of TLR receptors TREM2 SOST CLIP4 TIRAP TLR4 IRF3 DOK3 TRAF3 GRB2 TRAF6 MYD88 PMC8135095__F1 Microglia: A Double-Edged Sword in Intracerebral Hemorrhage From Basic Mechanisms to Clinical Research IFNG STAT1 TLR4 PMC8044534__F2 Diverse range of signals in the TME which could induce HMOX1 expression STAT3 BACH1 KEAP1 PMC8392882__F5 Critical Role of Growth Factors in Gastric Ulcer Healing: The Cellular and Molecular Mechanisms and Potential Clinical Implications EGF GRB2 CCND1 PMC3035360__F1 Synthetic view of the p53 pathway BAX PLK2 ID4 PML MDM2 MYC PIN1 PMC4329310__F4 Detailed view of protein secretion pathway UGGT1 KEAP1 ATF4 EIF2A XBP1 PMC9142883__F7 Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer’s Disease in APP/PS1 Transgenic Mice CTRL CTRB1 LAT2 NACA PMC3933272__F4 WNT signaling pathway ARHH APC SI HEL-S-11 HP NLK PMC6015534__F1 Schematic describes the major developmental steps that underlie the differentiation of preskeletal mesenchymal cells toward endochondral (right) and intramembranous (left) ossification SOX6 SOX9 ATF4 RUNX2 SOX5 MEF2C MEF2D RUNX3 PMC11658145__F7 Schematic summary of the effects of PEVs on the MV3 and A2058 spheroids CRP CD81 CD9 CD63 PMC8054189__F1 Aminoglycerophospholipid biosynthetic pathways in yeast, Saccharomyces cerevisiae CDS1 PC PSD2 PMC7664432__F1 Complex regulation of E-cadherin expression STAT3 SMO PMC4380406__F1 Impact of Host Diet on Wolbachia Titer in Drosophila RHEB TSC2 TSC1 MYC PMC8220701__F1 Genome-wide expression and network analyses of mutants in key brassinosteroid signaling genes MAX BIN2 SNRK BAK1 PMC9261067__F7 Circ-FOXM1 promotes the proliferation, migration and EMT process of osteosarcoma cells through FOXM1-mediated Wnt pathway activation FOXM1 MMP2 MMP9 CTNNB1 PMC7468828__F7 Monophosphoryl lipid A pretreatment suppresses sepsis- and LPS-induced proinflammatory cytokine production in the medullary thick ascending limb TLR4 IRAK1 TNF MYD88 PMC4800028__F1 CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance CD36 ADIPOR1 ADIPOR2 TLR4 PMC11741906__F5 Effect of differentially expressed miRNAs related to cisplatin resistance on MAPK signaling pathway MAX AKT3 NLK DAO FLNA PMC7779440__F3 TNF Signaling Pathway (Retrieved from KEGG) as One of the Pathways of Brazilin Targets in Metastatic Breast Cancer MMP14 MME ITCH SELE LIF CASP3 TNF FADD PMC3097535__F5 Global gene expression and Ingenuity biological functions analysis on PCB 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities CHRNA3 STAT1 NR1C2 CP PMC8305863__F2 Of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapy TBK1 CGAS BCR TLR4 APC TLR9 IL18 NOD2 IRF3 IRF7 TRAF6 MYD88 PMC3097535__F4 Global gene expression and Ingenuity biological functions analysis on PCB 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities CTNND2 RPL23A F2RL1 CP PMC11171836__F11 Mechanism by which Pin1 regulates NAFLD FASN PIN1 CPT1A PMC6700826__F7 Putative regulatory pattern of PoSet1 and PoSet2 on cellulolytic enzyme gene expression TF ME3 ME2 ME1 PMC8870972__F3A Eutopic Endometrium Proteome in Endometriosis Reveals Candidate Markers and Molecular Mechanisms of Physiopathology RHEB SYK TSC2 BAD BCR CD37 MCL1 RBL2 CD19 PTEN MDM2 PMC3165467__F6 Results of Ingenuity pathway analysis APOH ELANE PMC3878201__F4 miR-34a mediates paclitaxel resistance via both direct and indirect mechanisms CDK6 BCL2 ZEB2 SIRT1 PMC12075250__F2 AECAs pro-apoptotic and pro-inflammatory effects in ECs BAX FAS VCAM1 FADD PMC1770611__F2 Axin in Wnt signalling APC CTNNB1 PMC6328866__F3 Gene expression profiles analysis identifies a novel two-gene signature to predict overall survival in diffuse large B-cell lymphoma HEL164 MASTL ALDH18A1 BUB1B FCER2 MYBL2 ZWINT KIF23 HCN4 GPN3 TSPYL5 MRPL15 DRD4 SNRPB SLBP TPO PHOX2A TRAF3IP3 RCAN3 HCN2 RPL37A E2F8 HEL-S-133P DTL HSD17B10 NAMPT ADSL PGAM1 HEL-S-66p MCM10 RAB37 GPNMB ZNF350 SKA1 GNG7 HIVEP2 KIF15 NPPC DEPDC1 DLGAP5 KLHL34 CDC20 VBP1 SPNS3 PCNA TULP4 ZMAT1 GPR150 ZSCAN10 CASKIN1 ZNF823 UCN2 KLHL23 LBX1 C11orf21 SLC25A33 GAPT TSTD1 DEPDC1B CACNA1I FOXN2 CCR6 AIMP2 TTK CDCA8 SCGB3A1 STIL AK5 FAM83D GINS1 ACP2 DBF4 MFAP1 TRIP13 ZFP36L2 GLIPR1 NUF2 FRK RRM2 MAD2L1 DEK BYSL RAD51AP1 HEL-S-162eP CRHR2 ZBTB16 SCT SKA3 PMC10750287__F4 Cross-Communication of Cuproptosis and Regulated Cell Death in Human Pathophysiology NLRC4 GSDMD CASP8 NLRP3 CASP3 PMC8634458__F1 Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer TBK1 CGAS IRF3 PMC10750287__F6 Molecular mechanisms of autophagy triggered by excess Cu ATOX1 CCS KEAP1 SCO1 ULK1 F2 SCO2 MTOR ATP7B COX17 HEL-S-44 ATP7A PMC11741906__F4 Effect of differentially expressed miRNAs related to cisplatin resistance on PI3K-Akt signaling pathway BAD BCR RBL2 CD19 PTEN PMC8071856__F1 Endothelial and Vascular Functions by Carbon Monoxide via Crosstalk With Nitric Oxide TFAM NAMPT NRF1 SIRT1 PMC8898094__F4 Kinase-Catalyzed Biotinylation to Map Cell Signaling Pathways: Application to Epidermal Growth Factor Signaling KRT1 TNPO1 ABCC1 CANX TGOLN2 PCCA DBT FMNL2 HSPD1 PES1 EIF3F TPD52 HLTF PC AAG1 HNRNPK AHNAK NOMO1 MSH6 TARDBP RAD50 OPA1 HEL70 S100P CAND1 PSMC4 CHD4 PDHA1 BCAP31 RBM4 HEL-S-68p PSMC6 SUCLG2 VAPA RPN1 EIF3B PLP2 HLA-A RNPS1 GNA13 ATP2B1 NUP214 SGPL1 TIMM44 POLR3A PLAA RAB21 RBBP7 DHX15 HEL-S-2a ZFR ACTG1 PA2G4 AGPS NSUN2 CDC73 DNAJC7 EIF2S2 PPP2R1A HEL-S-30 EXOSC3 PHB2 TNRC6B HEL-S-162eP VAT1 CREBBP EP300 RPP25 CPT1A DDX3X PS1TP5BP1 FUS SEC61A1 SRRT EXOC4 SRP14 OTULIN SLC7A5 DECR1 NUMA1 SEC22B ADRM1 PRPF6 BAG2 TRIM28 AP2A1 RPL27A PNN E2F8 EIF3A MRPS2 HEL-S-28 PABPN1 PICALM PDHX MCM7 EIF3G PPT1 MCM3 MCM6 FDFT1 SND1 LMAN1 AKAP8L SF3B1 GAPVD1 ARCN1 EGFR ATP2B4 AHNAK2 VCP TCERG1 CLCC1 CCAR2 SURF6 CCDC47 ERGIC3 LUC7L2 FAM120A FOXN2 RPS3 CDC5L EEF1E1 SNRPA MTA2 S100A6 SEL1L PCBP1 SEC61B CD44 SEC31A FTH1 FAM98B MTDH ITGB1 STOM IPO9 DNAJA2 COG1 HSDL2 MAGED2 PMC6873421__F2 MET amplification causes EGFR-TKI resistance by activating EGFR-independent phosphorylation of ErbB3 and consequent downstream activation of the PI3K/AKT pathway, providing a resistance mechanism that can bypass the effects of an EGFR-TKI ERBB3 EGFR PDK2 PMC4099115__F4 IPA metabolic interaction network of plasma metabolites having a significant correlation with polyp counts in association with aGenotypebyDietinteraction effect TES FER AIP APP PMC4099115__F3 Metscape gene-compounds metabolic network views of top IPA canonical pathway and biological function/disease ART5 ART3 ART4 TNKS2 PARP4 PARP16 POLR2K NNMT PARP12 PARP11 POLR3B PARP2 TIPARP PARP10 PARP14 POLR3F BST1 POLR2F PARP1 POLR2G POLR2B TNKS POLR2D PARP3 POLR3K PMC2777340__F4 Drosophila insulin signaling pathway RHEB TSC2 RICTOR TSC1 PTEN GRB2 SHE PMC1622797__F5 Proposed molecular model of dietary omega-3 fatty acid interference with IL-1 signaling pathways leading to COX-2 induction in EC GP9 COX2 PMC9367715__F2 NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells RBX1 KEAP1 DPP3 PALB2 PMC9367715__F1 NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells RBX1 KEAP1 PMC5712004__F3 Model depicting targets of CHOP-dependent apoptosis BAX EIF2A FADD PMC8966655__F6 Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway GPX4 SLC7A11 PMC3961481__F1 Novel pathway links telomeres to NK-cell activity ATR HS3ST4 ATM POT1 TPP1 PMC9108237__F11 MicroRNA-382 Promotes M2-Like Macrophage via the SIRPA/STAT3 Signaling Pathway in Aristolochic Acid-Induced Renal Fibrosis STAT3 SIRPA ARG1 PMC6315745__F1 Chemoresistance LATS1 CDH2 STAT3 LATS2 PMC9652818__F1 N6-methyladenosine (m6A) modifications in gynecologic cancers: mechanisms and therapeutic targeting IGF2BP1 AXL FZD10 YTHDF1 TROAP PDE1C EIF3C UBA6 HOXA10 ALKBH5 YTHDF2 METTL14 BMF METTL3 TRIM29 ATG5 PMC7924916__F1 Severe acute respiratory syndrome coronaviruses’ lifecycle and possible mechanisms of interference with p53 and its regulatory pathways MPL PHB2 NPS PPIB HEL-S-69p PMC7795259__F1 Fibrosis related intracellular Ca2+signaling pathways PC HEL-S-11 MTOR PMC9652818__F3 N6-methyladenosine (m6A) modifications in gynecologic cancers: mechanisms and therapeutic targeting IGF2BP1 SOX2 IGF1R YTHDF1 MTOR IRS1 PRR5 PADI2 PEG10 PHLPP2 ALKBH5 WTAP YTHDF2 METTL14 METTL3 HOXB13 SOX4 PMC8599155__F3 Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19 TMPRSS2 TRPV1 ACE2 PMC7403443__F1 Crosstalk between intestine and liver in the pathophysiology of NAFLD FGF8A NR1C1 S1PR2 TLR4 GIP PMC1839882__F9 Schematic illustration of the principal signaling pathways that are affected by sodium arsenite (As) treatment STAT3 FAS EGFR BRAF ATF2 PMC5368685__F2 Pro-inflammatory response through TLR: various antigenic molecules are recognized differentially by TLRs, which produce pro-inflammatory responses TLR1 TLR4 TLR9 TLR7 MYD88 PMC12134845__F2 Amino acid metabolism in osteoporosis: Effects on the bone microenvironment and treatment strategies (Review) HDAC3 STAT3 CXCL12 IL10 GLS AHR MTOR PMC12134845__F1 EAAs are crucial for osteoblast function; their deficiency activates MAPK signaling, causing cell cycle arrest, ROS accumulation, DNA damage and apoptosis SLC7A7 NFATC1 MYC PPY PMC6667378__F1 Graph representation of the Signaling by NOTCH2 pathway as extracted from the Reactome database MDK UBC MIB1 DLL4 NEURL1B CNTN1 RPS27A MAMLD1 NOTCH2 RBPJ PSENEN MAML1 MAML3 APH1B PSEN2 MIB2 JAG2 ADAM10 EP300 MAML2 UBB PMC5558095__F7 Noncanonical GLI1 signaling sustaining LAC growth and CSC maintenance SHH NRP2 SMO VEGFA ABCG2 PMC4742232__F6 Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERAlpha-ΔNp63-Integrin B4 Signaling Pathway ITGB4 BMP4 SHH PMC3966702__F7 ABCA1 expression and function can be induced by GPR119 to protect from atherosclerosis GPR119 TNF ABCA1 IL1B PMC7077540__F9 CXCL12 and receptor CXCR4/CXCR7 in placenta accrete spectrum disorders (PAS) CDC42 CXCL12 RHO CXCR4 RAC1 PMC8348042__F2 Transient Receptor Potential Channels in the Epithelial-to-Mesenchymal Transition EGF SNAI2 TRPM7 HGF TRPC1 TRPC5 TRPM8 CTNNB1 TRPM2 TRPV2 TRPC6 TRPC3 SOX4 PMC6126184__F6 Pathway diagram presenting chaetominine mode of action associated with cell cycle regulation in SW1116 and K562 cells ATR CDK2 ATM CDK4 PMC9695749__F7 Mulberry Leaf (Morus alba L.) Extracts and Its Chlorogenic Acid Isomer Component Improve Glucolipotoxicity-Induced Hepatic Lipid Accumulation via Downregulating miR-34a and Decreased Inflammation NR1C1 FASN SIRT1 PMC4522377__F1 Multifaceted Control of DNA Repair Pathways by the Hypoxic Tumor Microenvironment FANCD2 ATR TLK1 BRCA1 H2AX RAD17 ATM MDC1 PMC3607745__F2 Cytokine and downstream signalling pathways in liver ischaemia reperfusion injury TLR4 STAT4 IL8RB CXCL10 PMC4145026__F1 Non-coding RNA regulation of synaptic plasticity and memory: implications for aging YY1 BDNF SIRT1 PMC7866901__F1 Expression characteristics and prognostic roles of autophagy-related genes in gastric cancer GABARAP GABARAPL1 MAP1LC3A WIPI2 ULK1 ULK4 WIPI1 DKFZp762B153 ATG3 PIK3R4 ZFYVE1 ATG2A RB1CC1 ATG5 ULK2 ATG16L1 VMP1 ATG14 ATG2B ATG101 ATG10 MAP1LC3C ATG16L2 ATG12 ATG9B ATG9A AMBRA1 NRBF2 MAP1LC3B2 GABARAPL2 PMC8854490__F1 Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse Functions TBK1 CGAS IRF3 PMC9222487__F8 Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases MAX STAT3 HEL-S-133P TLR4 GHB2 PMC7697665__F4 Role of RNF11 in the NFKB signaling pathway TBK1 TRADD RNF11 TAB3 IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 TRIM25 TRAF2 FADD PMC7658606__F6 Diagram showing the mechanism of Tanshinone IIA on EMT and metastasis in colorectal cancer CDH2 APC GSK3B CTNNB1 PMC7441421__F2 Signaling pathways mediated by CTHRC1 involved in the progression and metastasis of tumor TGFA SMAD2 APC SMAD4 ARHA GRB2 MTOR CTNNB1 PMC5881740__F1 JAK-STAT signalling pathway IFNG JAK3 IL2 IL6 JAK1 TYK2 PMC5031078__F1 RAF/MEK dependence of KRAS mutant pancreatic ductal adenocarcinomas NF1 PTEN KRAS IRS1 PMC5501956__F3 KEGG MAPK signaling pathway (KEGG ID: hs04010) MAX ECSIT JUND FAS FRK CD14 TNF TRAF6 FLNA MEF2C NGF NF1 NLK TRAF2 PMC4745004__F8 Colorectal cancer characterization and therapeutic target prediction based on microRNA expression profile BAMBI IFNG RBX1 THBS1 E2F4 FST PI3 ROCK1 SMAD4 SKP1 NODAL ARHA PMC7864517__F2 In the absence of Hedgehog (HH) ligand (SHH, IHH, and DHH), the Patched 1 (PTCH) transmembrane receptor at the base of the primary cilium maintains inhibition of Smoothened (SMO) G protein coupled receptor (GPCR) signaling VEGFC KIF7 SUFU SOX2 SHH BCL2 SMO TWIST2 GLI3 PMC8901637__F6 Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased B2 adrenergic agonist LATS1 MMP7 LATS2 PFKFB4 HEL-S-133P MCL1 GSK3B RHO GPR55 BIRC2 CTNNB1 PMC4568905__F5 2-Hydroxy Acids in Plant Metabolism HEL-S-162eP PMC8386020__F4 Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers RHEB INF2 EGFR PMC6031751__F8 CS negatively regulates IL-1B secretion in murine macrophages NLRP3 TLR4 IL1B PMC7738619__F1 Summary of the epigenetic regulation of the GSC phenotype ME3 STAT3 REST KDM1A TRIM24 ME2 KMT2E PRC1 NEK2 TUG1 PMC9104610__F6 Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling VEGFC TGFB1 ANGPT1 CALCRL VEGFA ANGPT2 PMC4932205__F4 Genes which are involved in the telomere maintenance and telomerase activity pathway XRCC5 RAD50 TINF2 TERF2 DKC1 NBN ATM TERT TEP1 TERF1 POT1 PMC5477652__F1 Targeting the cyclin D–cyclin-dependent kinase (CDK)4/6–retinoblastoma pathway with selective CDK 4/6 inhibitors in hormone receptor-positive breast cancer: rationale, current status, and future directions CDK6 SP1 GRB2 MTOR SHE CDK4 PMC3808847__F1 Kisspeptin and Neurokinin B Pathway Deficiencies and Resulting Phenotypes in Mice and Men KISS1 IHH PMC3822533__F3 Unfolded protein response in mammalian cells ATF4 TRAF2 PMC7146376__F2 Location of CYP27B1 activity in the metabolic pathway of vitamin D (based on Jenkinson 2019 and Feldman et al NR1i1 CYP2R1 CYP27B1 CYP24A1 DHCR7 CYP3A4 CYP27A1 PMC4020326__F2 Glucogen‐like peptide‐1 and cancer IGF1 IGF1R IGF2 PMC7893032__F1 Cell death in head and neck cancer pathogenesis and treatment RIPK3 TRADD MLKL TNF PMC9170601__F3 Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy ATF3 ATF5 ATF1 ATF7 ATF2 PMC8199938__F5 Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders TRPV1 FAAH GPR55 PMC7893032__F2 Cell death in head and neck cancer pathogenesis and treatment HMGB1 GSDMD NLRP3 DFNA5 RAC1 IL1B PMC7193099__F2 Hippo pathway in heart development and homeostasis LATS1 TAOK1 LATS2 PMC7327153__F2 TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics TLR1 TIRAP IRAK1 TRAF6 TLR10 IRAK4 IL1B MYD88 PMC6389705__F1 Intrinsic and extrinsic pathways of neutrophil apoptosis TRADD TNF FADD PMC4268391__F1 RTK-PI3K-AKT signaling pathway RHEB TSC2 TSC1 PTEN IGF1R MTOR MYC PMC9325865__F1 Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR) ELF2 ATF4 EIF2A XBP1 PMC8905337__F1 Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs TF GDF10 SMAD1 GDF8 DKFZp781O1323 SMAD2 GDF6 GDF5 GDF3 gdf7 GDF11 CRIPTO BMP2 GDF1 PMC3018096__F1 Adapters in the organization of mast cell signaling FYN GRB2 LAT2 GAB2 PMC9406569__F4 Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers RHEB TSC2 TSC1 CTSK TFEB MTOR TRAF6 PMC3149150__F2 Regulation of STEP phosphorylation NRG1 FYN ERBB4 PMC9406569__F6 Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers STAT3 RAN TIRAP AGAP2 CTSK CD14 SMAD4 IRF8 MYD88 TGFBR1 PMC5056850__F2 Signaling via PINCH: functions, binding partners and implications in human diseases RSU1 HEL-S-28 NCK2 PMC9406569__F5 Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers RHEB TSC2 TSC1 CTSK MTOR PMC3989668__F2 Ubiquitin-proteasome system maintains the balance between quiescence, self-renewal, and differentiation of HSCs.(A) The E3 ligases Itch, SCFFbxw7,CBL and SCFSkp2 maintain the quiescence of the HSC by targeting Notch, c-Myc, and STAT5, among others FANCD2 FBXW7 CBL ITCH USP1 MDM2 SKP2 VHL PMC4156155__F1 INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE LOX TLR4 SRC PMC4030154__F2 Metals and cholesterol implicated in AB processing and neurotoxicity IDE APOE LDLR ABCA1 PMC3630242__F1 Leptin and adiponectin activate signaling components that integrate PI3K/Akt, RAS/MAPK, and pAMPK/mTor pathways CRP JUN APPL1 ADIPOR1 ADIPOR2 PTEN SOCS3 FOS IRS1 TSC2 NR1C1 PPA2 CCND1 PMC3989668__F3 Ubiquitylation maintains the equilibrium between differentiation and transformation in adult stem cells FBXW7 RNF43 ITCH APC ZNRF3 SMURF2 CTNNB1 PMC7665057__F6 Predicted pathway and network of all the 11 miRNAs SNAP23 KLF3 IL10 GULP1 PER2 SLC25A20 PIK3R1 HIF1A VEGFA NUS1 CXCL8 THRA PER3 SLC52A2 FKBP1A FGF20 IL6ST NR1A2 BCL6 PMC9039247__F2 Cellular Metabolism in the Formation of Neutrophil Extracellular Traps in Airway Diseases PANX1 GLS MPO PMC1716221__F1 Dominant role for glucose in B cell compensation of insulin resistance IGF1 INSR FOXO1 PDPK1 GCK PMC7763279__F2 Wingless and Int-1 (WNT) signaling pathways and their role during the osteochondrogenic transition of synthetic vascular smooth muscle cells (VSMC) ACAN ROR1 SOX6 SOX9 WNT3A ROR2 LRP5 LRP6 RUNX2 SOX5 COL2A1 CTNNB1 PMC7055192__F3 Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies ABCG1 APOE LDLR PMC3218875__F2 Noncanonical NFKB signalling CD40 LTBR RELB TRAF1 TRAF3 TRAF2 PMC8534120__F2 Sphingolipids in Hematopoiesis: Exploring Their Role in Lineage Commitment CERS3 CERS5 ACER1 SGPL1 CERS1 SGMS1 CERS2 SPHK1 SGMS2 DEGS2 SMPD1 KDSR SGPP2 SMPD2 CERS6 ASAH2 SMPD4 SPTLC2 SPHK2 SGPP1 PC SPTLC1 ACER3 PMC7763279__F3 Interplay of WNT and PPARG Signaling in Vascular Calcification HDAC3 SFRP5 DKK1 APC LRP5 LRP6 CCND1 CTNNB1 PMC3902114__F1 Targeting inflammatory cytokines-androgen receptor (AR) signaling with ASC-J9® to better battle prostate cancer progression CCR2 CCL4 CCL2 PMC4516600__F4 A schematic pathway for one mechanisms of cisplatin-induced ototoxicity involves TRPV1 activation by cisplatin leads to NOX3-dependent generation of ROS to trigger STAT1 activation STAT1 NOX3 TRPV1 PMC9433531__F4 Mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations EGF EGFR MTOR PMC5812366__F1 Major mechanisms of therapeutic resistance to androgen axis-targeting therapies in prostate cancer BAX EGF TRIM24 IGF1 SMAD2 SMAD4 BCL2 PTEN MDM2 MTOR TGFBR1 PMC7333666__F1 Simple overview of the Hippo signaling pathway and YAP LATS1 LATS2 RUNX1 TEAD2 ERBB4 TEAD3 NRP1 NF2 TBX5 RUNX2 TEAD4 PMC7002859__F1 Steroidogenesis pathway involved in testosterone synthesis from cholesterol in testicular Leydig cells HSD17B3 STAR HSD3B1 PMC4128657__F4 An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients RNASEL IRF3 TLR7 PMC4128657__F5 An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients GYPB JUN IRF9 RIPK1 IRF3 ATF2 ISG15 PMC4491880__F1 Deoxycytidine biosynthetic pathway DCD OMP DUT PMC8387860__F2 Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls BAX BAD SRC APAF1 PMC9203694__F6 Microrchidia CW-Type Zinc Finger 2, a Chromatin Modifier in a Spectrum of Peripheral Neuropathies ACLY FAS MORC2 PMC9203694__F5 Microrchidia CW-Type Zinc Finger 2, a Chromatin Modifier in a Spectrum of Peripheral Neuropathies CDC2 PAK1 MORC2 ATM PARP1 PMC5797330__F3 Endothelial Progenitor Cells for the Vascularization of Engineered Tissues CDC42 PC EGFL7 RHO RAC1 CTNNB1 PMC8346997__F2 GPR39 in Neurovascular Homeostasis and Disease GPR39 RHO BDNF PMC12240974__F1 BAF60c in skeletal muscle glucose metabolism and regeneration DKK3 SIX4 DEPTOR PMC4824131__F1 NRAS mutant skin cell lines mutations in the TLR3 Cascade pathway MAPK14 MAP2K6 RPS6KA2 NFKBIA MAPKAPK3 NRAS MAP3K7 IRAK2 IL6 RPS6KA5 IL6R PMC7477231__F8 Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway ME3 HEL-S-68p GC MSC EZH2 PTEN PMC9565660__F1 Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis HEL-S-62p C2 PMC7333666__F3 Role of YAP in the cytoplasm and nucleus regarding central nervous system disease STAT3 TEAD2 ERBB4 SOCS2 NF2 PMC8943788__F6 rs2671655 single nucleotide polymorphism modulates the risk for gastric cancer in Helicobacter pylori–infected individuals: a genome-wide association study in the Korean population SPOP GC ZNF652 PMC6830101__F12 Graphical summary of perceived crosstalk of BMP2-mediated signaling and the NO pathway SMAD1 DKFZp781O1323 BMP2 SMAD4 PMC10341762__F1 One-carbon metabolism MTHFD1 BAD DHFR MTRR HEL-S-61p PMC6651320__F1 Schematic representation of MVA pathway HMGCR SQLE DHCR24 DHCR7 PMC9069407__F3 Generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation STAG2 KPNA2 IFNG STAT3 HEL113 SPOP STAG1 GSDMC CMTM6 CMTM4 PMC7565951__F2 Roles of TRIM proteins in pattern recognition receptors (PRRs)-mediated immune signaling pathway TRIM44 TBK1 MAVS USP15 TRIM25 IRF3 IRF7 TRAF3 PMC7235403__F7 Lysosome pathway in DEX-treated sarcoid AMs ACP2 GAA TCIRG1 GUSB CTSK GLA ATP6V0D1 HGSNAT PRKCB LIPA NAGA LITAF GNS SGSH GALNS AGA ABCB9 PMC7235403__F6 Effect of DEX on metabolic pathways in sarcoid AMs HEL60 IDH3B NDUFA6 AOC2 COX6A1 PIG59 COX8A UQCRHL NDUFA3 ACOX3 MDH2 AASS ACO2 HK2 ACADS HEL-S-30 SDHD UQCRC1 SDHA PPARGC1B ACAT2 OGDH ALDH7A1 UQCRFS1 ENO1 HEL-S-87p COX11 COX6B1 PMC4724610__F1 Systematic representation of microRNA biogenesis, deregulation and function RAN DGCR8 AGO2 DROSHA PMC12119277__F3 Mechanisms by which mediators of inflammation resolution regulate neutrophil apoptosis and survival BAX BAD GPR37 MCL1 ANXA1 FPR2 APAF1 LGR6 MPO PMC1851054__F6 SFK-dependent PI3K-ERK2 and phospholipase CG-JNK1 pathways CD48 HLA-E HEL-S-62p PAK1 VAV1 MICA RAC1 PMC12119277__F2 Neutrophil apoptosis BAX MCL1 APAF1 PMC3395736__F1 Glycolytic pathway and its metabolic interconnection with the pentose-phosphate pathway HEL-S-162eP PMC6412216__F5 Mediation of the maturation and activation of BMDCs during Mycobacterium bovis infection by the cGAS pathway TBK1 CGAS IFNAR2 IFNAR1 IRF3 PMC3639292__F3 Metabolic rewiring in melanoma engages more carbon than just glucose FAS GLS PHGDH GPT PMC4628764__F1 Heme biosynthetic pathway in erythroid cells SLC25A38 ABCB6 ALAS2 FECH ABCB10 UROD UROS TMEM14C VIT HMBS CPOX STEAP3 SLC36A1 PMC5406702__F3 EGFR family members regulate autophagy affecting cancer cell survival and death TSC2 LAPTM4B TSC1 ATG12 ULK1 EGFR UVRAG AMBRA1 ATG14 PMC5777650__F6 Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy RICTOR PIR MTOR PMC2999286__F1 The involvement of the Unfolded Protein Response (UPR) signaling in lipid metabolism TG EIF2A XBP1 PMC5070725__F1 Schematic model of metabolic regulation by S6K1 in two ways WNT10B TSC2 TSC1 EZH2 WNT10A PMC6925592__F2 Smad7 Restricts DC Responsiveness to TGFB and Their Ability to Induce Tregs MLN TGFBI ID2 EVI1 MYC ID1 EMP1 BAMBI ENG INHBA RUNX1 INHA TOB1 FST GSC AMHR2 FOXP3 AMH SOX4 PMC8510449__F6 Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review ERCC1 CDK8 STAT3 BAD WEE1 PMC8510449__F5 Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review CD44 CD24 EGFR ZEB2 PMC8306430__F3 Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation CIC PIG59 SHANK1 GABRB2 PSMB10 HERC6 GABRB3 C1QB SOCS3 GABRG3 PMC5220041__F5 Thyroid cancer-related signaling pathway relational graph BRAF MMP9 MTOR PMC7105005__F2 CGAS/STING-signaling through Post-Translational Modifications (PTMs) RNF185 TBK1 TRIM38 CGAS TRIM32 TRIM56 RNF5 ULK1 IRF3 SENP7 RNF26 INSIG1 USP18 MUL1 USP20 AMFR SENP2 TRIM29 PMC8510449__F7 Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review WEE1 CCNB1 PMC3302314__F2 Left half, signaling via IPS-1 following dsRNA/ssRNA recognition by RIG-I and MDA5 TRADD NLRP3 TANK IRF3 IRF7 TRAF3 IL1B FADD PMC3302314__F1 Signaling cascade following TLR2/TLR4, TLR7/TLR8, and TLR3 activation with envelope glycoprotein, ssRNA, and dsRNA, respectively TIRAP TAB3 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 PDC TLR8 TLR7 PMC6550017__F5 GLI proteins are regulated by PKA ADRBK1 GPR161 SMO ARHGAP36 PMC11004261__F5 Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions WNT5B STAT3 BCL2L1 JUN CCNE1 CASP3 BCL2 MTOR SRC CCND1 FOS CDK4 PMC2925066__F1 Major Apoptotic pathways HTRA2 BAX FAS APAF1 DIABLO FADD PMC6550017__F1 HH signaling EVC SUFU SMO PMC11004261__F4 Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions MDM2 PMC6824835__F2 AKAP5 and AKAP12 in modulating oxidative stress in cardiac cells TGFBR2 AKAP5 TGFB1 SMAD2 AKAP12 TGFBR1 PMC11004261__F3 Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions GSK3B EZH2 DPYSL3 PMC9453300__F3 Emerging role of different DNA methyltransferases in the pathogenesis of cancer BAD PI3 PTEN MDM2 PMC11994733__F1 Suitable concentrations of brassinolide application enhances growth performance and saikosaponin biosynthesis by transcriptional activation of triterpenoid pathway genes in Bupleurum chinense DC IPP MVD MVK PMC4977886__F4 Differentially expressed proteins regulated cellular processes/diseases and hypothetical depiction of BPA action SDHB PS1TP5BP1 PMC2720436__F1 Hippo pathway, a vital growth regulator of cell proliferation and apoptosis was initially identified by mosaic screens in Drosophila melanogaster (,) LATS1 BIRC5 MCL1 BIRC2 PMC8332859__F8 CR13626: a novel oral brain penetrant tyrosine kinase inhibitor that reduces tumor growth and prolongs survival in a mouse model of glioblastoma FYN KL RET PMC3223252__F7 A refined model shows MEHP-decreased TIMP2 expression in Sertoli cells is mediated by the inactivation of CEBPA and the activation of MYC and is dependent upon the FSH-stimulated cAMP signaling pathway CEBPA MMP2 FSHR MYC PMC3897272__F1 Eicosanoid biosynthetic pathway LOX COX1 COX2 C2 EGFR PMC11994733__F6 Expression of key genes in the saikosaponin biosynthesis pathway in B IPP BRS3 LBR PMC5462947__F4 Metabolic traits of KF-JG30-18 (A) and DA052 (B) as derived from the genetic potential of RH2 MAG 17b and RH1 MAG20 LIAS MAL CIT PMC4038253__F1 Simplified scheme of the N-glycosylation pathway ALG12 ALG6 RFT1 ALG10 MGAT3 ALG2 ALG13 MGAT2 ALG1 ALG3 DPAGT1 PMC8123211__F3 PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions CXCL12 CCL3 PARP2 SRC CCL2 PARP1 PMC8123211__F2 PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions CD44 RNF2 PARP10 HEL113 RNF146 AMOT LRP5 LRP6 PARP3 PARP1 PMC7062835__F1 Molecular network identified using the “Interaction search” algorithm in KeyMolnet JUP MAPK1 NAPB HEL-S-67p GNB2 MAPRE3 APC SNCA ARHA TUBB MYC PID1 MAPK3 ADRBK1 GNB1 ALB HPCA GPD2 HEL-S-29 AK1 PRKCA MAPK10 PMC6276090__F4 Signaling pathways in osteoclasts involving V-ATPases RHEB LRP5 LRP6 TRAF6 CSF1R CTNNB1 PMC6627782__F3 mTOR signaling in spermatozoa from older men RPS6 MLST8 RPS6KB1 AKT1S1 MAPK8 DEPTOR PMC9659959__F1 Nucleic acid-sensing toll-like receptors: Important players in Sjögren’s syndrome TBK1 UNC93B1 TLR3 TLR9 TLR8 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC6627782__F2 Network of the sperm proteins differentially associated with male age TTLL12 BAD MAPK11 MAPK13 AKT3 HEL-S-269 GSK3B MTOR MAPK8 MAPK14 YWHAQ CLU HSPA2 MYH9 ACTL9 MAPK12 AKT1S1 RPS6 DCXR ANXA3 MYH10 HEL-S-7 FASN S100A6 CCT7 HEL-S-130P PFKP PATE1 RPS6KB1 CASP3 HEL-S-102 HSPA4 PMC5564615__F7 Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway SP1 MDM2 PMC2995824__F1 Regulation of muscle protein synthesis PRR5 RHEB TSC2 RICTOR TSC1 MTOR DEPTOR EIF4E PMC3786361__F1 Epidermal growth factor receptor family and targeted agents EGF HBEGF TGFA EGFR BTC PMC9597983__F2 Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential BAX BAD FAS NANOS1 INSR EGFR BNIP3 CDK2 IGFLR1 PMC3829478__F9 Wnt3a binds to Fz7 and cross-activate the IGF-1-PI3k-Akt pathway inducing initial axonal outgrowth and neuronal polarization WNT3A FZD7 WNT3 IGF1R PMC4772995__F2 Whole Transcriptome Analysis (RNA Sequencing) of Peripheral Blood Mononuclear Cells of Vitiligo Patients HLA-G RFXANK DRAP1 NCLN ARHGEF10L DHX58 GAS2L1 SPCS2 OAS1 DNASE2 NOMO1 PMC22365__F5 Evolutionary conservation of the DNA damage and the replication checkpoints ATR CDS1 ATM PMC7844014__F6 Network of interactions significantly enriched for genes displaying altered methylation patterns following treatment with valeric acid MOV10 NASP ATG16L1 HMMR SREK1 FKBP3 CTNNA3 ATG12 DHX16 SAFB RIT1 MUC1 TRAPPC12 LANCL1 FYTTD1 PRCC TRAPPC6B ZNF317 HDAC6 PMC6497933__F6 Summary of the DEPs involved in central carbon metabolism and fatty acids synthesis FRK MAL CIT PMC2843167__F7 Summary of the findings presented here PCNA HDAC2 PMC4223335__F10 Concerted regulation of NFATc3 by electrical activity and NGF in sensory neurons NGF GSK3B NFATC3 PMC5831770__F1 Sonic hedgehog signaling pathway SUFU PTCH1 SHH SMO GLI3 PMC6003838__F2 The spatio-temporal cell dynamics of the G-protein/Pth11 and cAMP-signaling pathway during surface sensing and appressorium morphogenesis RGS1 PMC4090390__F2 Metabolic fluxes, NLRP3 and IL-1B NLRP3 TLR4 IAPP PMC4669123__F1 Mammalian “Obesogen” Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish ACOX1 DGAT2 FASN PMC4090390__F1 Pathogenesis of T2D: adipose tissue, the pancreas, NLRP3 and T2D IAPP IRS1 IL1B PMC4957946__F1 Differentiating mTOR Inhibitors in Renal Cell Carcinoma EGF EIF4B EGFR PTEN IGF1R MTOR VHL EIF4E RHEB MLST8 TSC2 EEF2K RICTOR TSC1 IGF1 PMC5649368__F3 Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors FAS tmp_locus_29 EGFR EZH2 SRC PMC5649368__F1 Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors SP1 GC PMC4824563__F3 Network analysis SOCS1 TNFRSF1B ACSL3 ABL2 PLK2 AIRE EFNA1 STRN3 HMOX1 CEBPD TAP2 MBNL2 BIRC3 TRIO TRIB2 IRF1 GBP1 DUT ID1 ENG MTDH USP3 RHOB TM4SF1 HEL-75 PMC6992624__F3 An integrated computational and experimental study to investigate Staphylococcus aureus metabolism MAL GIP CS ME1 THRA ASPA RPE PGC MALL ME2 PC TNLG7C NDP PMC9319476__F2 Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta DKK1 APC CTNNB1 PMC9580404__F3 Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis IL1R1 REST JAK3 TGFBR1 PMC8585775__F7 Proteomic Phenotyping of Stimulated Müller Cells Uncovers Profound Pro-Inflammatory Signaling and Antigen-Presenting Capacity IFNG HEL-S-99n HEL-S-269 PMC5572303__F5 Proteomic Analysis of Normal and Cancer Cervical Cell Lines Reveals Deregulation of Cytoskeleton-associated Proteins ABI2 HEL114 CRK EGF F2R PXN GNG12 FLNA DOCK1 PMC3413225__F7 Model describing the mechanisms of quercetin-induced cholesterol efflux in macrophages SP1 GC ABCA1 PMC3570300__F5 Ingenuity Pathway Analysis of proteins induced by DNP.A, overview of 15 specific functional networks, each of which contains 11 or more “focus” proteins (proteins that were significantly up- or down-regulated) TP73 STAT3 NDUFB8 DGAT1 EXOSC10 PXN EGFR PLAUR HEL-S-84 HTATIP2 MDC1 SATB1 IGF2 FXR1 SBDS C2 SNCG RP2 ITGA6 MMP2 BCL2 MTR PMC7697665__F2 Role of RNF11 in the transforming growth factor beta (TGFB) signaling pathway WWP1 SMURF1 ITCH SMAD2 RNF11 SMAD4 SMURF2 PMC3914023__F3 A model of the EZH2 functional switch from a polycomb repressor to a transcriptional activator in castration-resistant prostate cancer SUZ12 REST EED EZH2 SET PMC6829404__F8 Leptin-induced EMT via Src and FAK signaling pathways EGF EGFR SRC CTNNB1 PMC3527145__F1 The left-right asymmetry pathway LEFTY2 NODAL PITX2 PMC6539494__F4 Single-Cell RNA-Sequencing Identifies Activation of TP53 and STAT1 Pathways in Human T Lymphocyte Subpopulations in Response to Ex Vivo Radiation Exposure MYC PMC3690365__F2 Pathways that control levels of macroautophagy ATG12 ATG14 MTOR ATG5 PMC6708273__F6 Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic Beta-Cells to Type 2 Diabetes MAFA GRB2 MTOR MYC PAX6 PMC5209821__F4 Working hypothesis of the mechanism through which different miRNAs regulate the PTEN pathway, PI3K/AKT and STAT signalling in sperm RAF1 PIM1 GYS2 GYS1 CASP3 BCL2 PTEN MTOR JAK1 MYC PMC8616451__F1 Therapeutic Potential of MRGPRX2 Inhibitors on Mast Cells MRGPRX2 IL33 MYD88 PMC9369061__F1 JAK/STAT Pathway and Its Selective Inhibition in the Treatment of Atopic Dermatitis: A Systematic Review STAT3 STAT1 TSLP IF2B1 IL13 JAK3 IL4 JAK1 IL5 IL31 TYK2 PMC8497618__F8 Proposed model of how Enpp4/S1pr5 controls pronephros patterning ENPP4 PAX8 WNT4 S1PR5 PMC5564786__F6 MiR-650 represses high-risk non-metastatic colorectal cancer progression via inhibition of AKT2/GSK3B/E-cadherin pathway GSK3B CTNNB1 PMC6115855__F7 Anti-cancer mechanism of the PEC treatment in both AGS and MKN28 cells CDC2 MTOR EIF4E PMC11884773__F1 Coptisine ameliorates colitis in mice by modulating cPLA2/TRPM8/CGRP-1 signaling pathways and strengthening intestinal barrier function TRPA1 TRPV1 TRPM8 PMC7542154__F3 Immunoregulation of PD-L1/PD-1 in GBC ERBB3 EGFR ERBB2 MTOR PMC5711031__F10 Interleukin-1beta (IL-1B)-induced Notch ligand Jagged1 suppresses mitogenic action of IL-1B on human dystrophic myogenic cells CSF2 IL16 NOTCH3 CSF3 IL1B PMC8452392__F7 Exploring the Molecular Mechanism of Liuwei Dihuang Pills for Treating Diabetic Nephropathy by Combined Network Pharmacology and Molecular Docking TF BAX EGR1 PIM1 SELE SMAD2 SMAD4 MMP2 CPD CDK4 PMC4802778__F2 Role of sortilin in EV biogenesis TES RAB27A PMC3608394__F6 Enriched pathways and GO functional annotations are: (a) ErbB signaling pathway: p=9.10e-13; Signal transduction p=2.33e-07 THBS1 PTK6 SHC1 EGFR PPP2CA POFUT1 NOTCH2 ANGPT2 INS GRB7 INSR PSEN2 SNW1 HEL-S-1 MFNG SH2B1 NOTCH3 SRC NOTCH1 PMC8624197__F3 Bioconversion of Lignocellulosic Biomass into Value Added Products under Anaerobic Conditions: Insight into Proteomic Studies HBD PMC3608394__F5 Subnetworks identified from TCGA ovarian cancer gene expression data set MAX AURKA RAD51 GNG4 DMPK MYC RB1 BRCA1 CREBBP NRAS APP LFNG HEL-S-1 TBP SRC PMC8548690__F6 Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can IL17A TNF ACE2 PMC3608394__F7 Enriched pathways and GO functional annotations are: (a) NFKB signaling pathway p=7.03e-05 RSF1 GSK3B SMAD4 NCOA6 FOXH1 TOB1 NFKB1 IKBKB CREBBP UBE2D3 UBE2I CEBPB PRKAR1B CAMK2G NFKBIB PMC8539121__F1 In Vitro Analysis of Deoxynivalenol Influence on Steroidogenesis in Prostate HSD17B3 STAR CYP17A1 CYP11A1 PMC11010822__F7 MTA1/mTOR pathway in prostate cancer MTOR CCND1 PMC2409614__F3 Development of tamoxifen (TAM)-resistant breast cancer and the changing role of oestradiol (E2) in the life and death of ER-positive cancer cells FAS EGFR FADD PMC2601665__F1 Hh-Gli pathway and the Gli code in tissue patterning and stem-cell lineages REN ITCH SUFU PTCH1 GSK3B NUMB SMO PMC3148240__F1 Simulating EGFR-ERK Signaling Control by Scaffold Proteins KSR and MP1 Reveals Differential Ligand-Sensitivity Co-Regulated by Cbl-CIN85 and Endophilin EGF EGFR PTEN ARHA SRC PMC8857760__F3 Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights BAX FAS APAF1 PMC8857760__F2 Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights HMGB1 TLR5 MYD88 PMC3517080__F5 Putative Altered Signaling Events occurring upon treatment of GSI PA2G4 GFAP PCNA MYH9 PMC4657516__F5 Antioxidants in Translational Medicine KEAP1 MAF PTEN PMC9289522__F1 Distinct Cell-specific Roles of NOX2 and MyD88 in Epileptogenesis NLRP3 TLR4 IRAK4 MYD88 PMC8815087__F4 Phosphodiesterase 1 (PDE1) regulated cAMP and cGMP signaling pathway in cancer and neurological disorders PDE1B NACA2 CNP BDNF UHRF1 PMC9142082__F1 Double-Stranded Break Repair in Mammalian Cells and Precise Genome Editing PNKP WRN PAXX APLF PMC4155268__F5 The cytoprotective signaling of EPCR-APC APC ARHA RAC1 PMC11674240__F2 TRIM proteins in the signaling pathways TRIM16 TRIM31 TRIM14 TRIM32 TRADD SMAD2 APC SMAD4 TRIM59 TNF CTNNB1 TRIM21 TRIM44 TRIM50 TRIM28 TRIM24 TRIM25 TRIM47 TRIM52 TRIM11 TRIM58 TRIM29 TRIM65 FADD PMC3976840__F2 FASN related metabolic and signal transduction pathways ACLY FASN PTEN ACACA PMC8826578__F3 Review of LINC00707: A Novel LncRNA and Promising Biomarker for Human Diseases CDC42 CDCA3 CDK14 PMC8579148__F4 Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease RHEB EGF TSC2 TSC1 IGF1 ULK1 SRC ATG5 PMC8618147__F6 Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of Disease STAT1 NLRP3 STAT2 IRF9 TFEB TRAF3 ACE2 IL1B PMC8231629__F3 Impact of Hydrogen Peroxide on Protein Synthesis in Yeast EIF4B EIF2A EIF4E PMC4104069__F2 Pathways to Tumorigenesis and Persistent Infection TLR3 TLR4 IRAK1 IRF3 MYD88 PMC2668926__F1 EGFR Signaling Pathway CDK6 GRB2 CCND1 CDK4 PMC8831132__F1 NAD+ in COVID-19 and viral infections NRK SARM1 HEL-S-5 NAMPT PARP1 PMC8665869__F5 Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling STAT3 NLRP3 AIM2 IL1B PMC7813757__F1 Mechanism underlying the role of TLRs in tumor immunity TLR1 TLR4 TLR9 TLR5 TLR7 PMC5349223__F6 Regulation of Posttranslational Modifications of HMGB1 During Immune Responses ECSIT HMGB1 TIRAP TRAF6 MYD88 PMC8929128__F1 Impact of Vitamin D Supplementation on Inflammatory Markers’ Levels in Obese Patients NR1i1 CX3CL1 FAIM CYP27A1 PMC2875058__F2 Several disease pathways involved in AD pathogenesis CLU SORL1 APOE BACE1 PSEN1 CALHM1 CR1 PICALM PMC5493925__F3 Regulation of the zebra finch RLR pathway IFNE TANK IRF3 CYLD TRAF2 FADD PMC8174116__F5 Bioinformatics Analysis of a Prognostic miRNA Signature and Potential Key Genes in Pancreatic Cancer REG3G DGIC SV2B NR4A3 ADAM28 LONRF2 SCG3 SLC30A8 IAPP KIF23 CD109 ITGB6 ADHFE1 DCDC2 ASAP2 FOXQ1 DKK1 ITGA2 NQO1 SCGN F8 RTKN2 MLPH SCEL PCDH7 TNS4 VCAN SLC4A4 ABHD17C TRHDE ADAM9 BTG2 EDNRA COL12A1 EPB41L4B GLS2 COL5A2 NR3B3 NRCAM MMP14 TMEM97 FREM1 THBS2 BACE1 MCOLN3 AHNAK2 COL3A1 LMO7 PROX1 OLR1 COL1A1 INPP4B ST6GALNAC1 MTMR11 NR5A2 GABRP NPRC SDR16C5 PAIP2B TMC7 PGM2L1 C2CD4B PKHD1 FGD6 IGF2BP3 DPP10 CCDC141 ATRNL1 KCNJ16 NRP2 UNC79 ESM1 FABP4 EPHA4 MMP9 SLC7A2 GJB2 ANGPTL1 FNDC1 AGR2 PDK4 IGFBP5 MATN3 ACADL SLC1A2 FLRT2 SLC16A10 PMC7831039__F1 mut-p53 alters the communication of tumor cells with their microenvironment TBK1 DGKA APPL1 CXCL10 PMC10407612__F8 Ghrelin in promotion of ADMSCs cardiomyocyte differentiation SFRP4 GATA4 CTNNB1 PMC11810460__F3 Schematic representation of cellular targets of HDACi and targeted BRAF mutant therapy concepts of relevance for cell death mechanisms BRAF SLC7A11 GRB2 MTOR IMPACT PMC4866972__F1 Intrinsic and extrinsic pathways of apoptosis BAX TRADD TRAF2 DIABLO FADD PMC4866972__F3 Principal cell death pathways involved in intervertebral disc (IVD) degeneration RHEB TSC2 TSC1 BNIP3 MTOR DIABLO FADD PMC6710443__F10 Schematic diagram of the mechanisms about the role of HDAC3/NF-kappaB pathway in pathogenesis and exercise therapy of OA HDAC3 ADAMTS5 IL1B PMC3303591__F1 Stimulation of PI-3K/Akt signaling pathway after activation of IR/IGF-1R mediates insulin neuroprotection against damaging conditions GSK3B GPX1 PMC2529154__F4 Four components to yield MDP chromophore C6 C7 HEL-S-62p C2 NDP PMC6378136__F2 Endosomal sorting and trafficking, the retromer complex and neurodegeneration VPS35 BACE1 APP PMC5572632__F2 Salvianolic acid B protects against diabetic atherosclerosis via the Nrf2 signalling pathway KEAP1 NQO1 MAF PMC5483877__F1 Strategies of effective targeting of hepatocyte growth factor (HGF)/c-Met signaling for the prevention of hepatocellular carcinoma (HCC) HGF PI3 PMC8741925__F7 Mechanical stress dampens the CR, resulting in the degeneration of IVDs through the Rho/ROCK pathway ADAMTS4 MMP3 ARHA MMP9 PMC3952039__F1 To Bud or not to Bud: The RET perspective in CAKUT GDNF SRC RET PMC3063605__F1 Simplified cartoon of PRR signaling in epithelial cells showing only the canonical pathway of NFKB activation and some of the key receptors, adaptors, and kinases involved TLR1 TLR4 TLR9 TLR5 DAP MYD88 PMC5572632__F1 NFKB signalling pathway is involved in the diabetic atherosclerosis PC TRIB3 IRS1 PMC3271045__F4 Schematic summary of striatal gene expression changes in response to SNCA overexpression SYN2 DRD2 HEL111 DHCR24 CARTPT BDNF MEF2C PMC4465570__F3 Genome-wide association study points to multiple loci predicting antidepressant treatment outcome in depression HEL-S-22 RYR2 CD36 TNFRSF1A MYBL2 PON2 PTPRK PTPRS HAS2 APOB PTGER4 TNFRSF21 EPHX2 PMC10454149__F1 MiRNA-146a—A Key Player in Immunity and Diseases TLR1 CD14 TLR5 IRAK2 TRAF6 MYD88 PMC8193053__F9 Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages NLRP3 TLR4 CD14 IRAK1 TRAF6 LBP IRAK4 FADD MYD88 PMC6770479__F1 Molecular mechanisms involved in inflammasome activation NLRC4 NLRP1 GSDMD NLRP3 IL16 AIM2 PMC6770479__F3 Chemotherapy-induced apoptosis and pyroptosis in cancer cell BAX DFNA5 FADD PMC3514612__F7 Synthesis of nitric oxide and transduction cascades ARC BDNF PMC10454149__F3 MiRNA-146a—A Key Player in Immunity and Diseases HDAC1 MAP3K8 NFKB1 IKBKB TNIP2 RELA RELB NFKBIA CHUK EP300 REL PMC3533650__F10 Regulation of the FOXO3a survival, and glycolysis pathways under hypoxia in Spalax CITED2 HEL-S-133P HK2 PTEN MTOR MYC PMC10454149__F2 MiRNA-146a—A Key Player in Immunity and Diseases CD40 SYK KCP LTA LTBR TRADD TIRAP LAT TRAF3 TRAF6 MYD88 BTK RALB BCR TLR4 ATM CYLD CD14 BLNK TNF PARP1 LTB TRIM25 LBP EDAR PMC6904929__F2 MicroRNA Mediated Regulation of Immunity against Gram-Negative Bacteria TLR4 TLR9 TRAF6 MYD88 PMC9038741__F5 Metabolic reconstruction of Angelarchaeales-1 genome MAL HP CIT PMC6478758__F3 Pervasive regulation of TLR signaling pathway by miR-146a/b family and miR-125a~99b~let-7e cluster STAT3 CCL3 TLR4 IRAK1 TRAF6 TNF MYD88 PMC8870611__F2 Prognostic and Predictive Molecular Markers in Cholangiocarcinoma STAT3 EGF HGF EGFR SOCS3 MTOR FGFR2 PMC5030800__F10 The regulation of lysosomal biogenesis and autophagy by cathepsin B in response to infection with F ULK1 TFEB MTOR PMC4698384__F3 Downstream gene targets of predicted cytokine and transcriptional regulators STAT3 DBP TNFRSF1B GAS HLA-DRB1 EMP3 MARCKS CTSS SPI1 IGFBP6 MEF2C PER3 IFNG POSTN HLA-E CD74 CASP4 CNN2 WEE1 THBD SOAT1 GBP2 DCN NOTCH1 ACP5 FCGR2A IL1B IL10 ID2 SERPING1 CFD HLA-DQA1 COL14A1 ADAMTS5 TBX5 TNF IRS1 CEBPA HLA-DMA MRC1 UGDH MGP NFKBIA LCN2 XLKD1 CYBB PMC7056466__F1 Hydroxytyrosol (HT) and its main biological actions STAT3 BAX PMC4336643__F8 Proposed signaling pathway NR1i1 JUN UNK PMC3436686__F6 Ensemble representation of EGF signalling network EGF HEL113 PRKD1 RAF1 SHC1 SOS1 ITGB4 PXN EGFR PRKCZ MAPK3 GRB10 PRKCA SRC MAPK1 JUN PTPN11 FOS ARAF HRAS SPRY2 CBL BCL2 MAP2K1 GRB2 PMC3186711__F8 A model of the role of TLR4 signaling pathways in regulating TNFA expression TLR4 MAL TNF MYD88 PMC4046345__F2 dsRNA-Activation of TLR3 and RLR Signaling: Gene Induction-Dependent and Independent Effects BAX TBK1 MAVS IRF3 TRAF3 TRAF6 TRAF2 HDAC6 PMC5601671__F6 The apoptotic signaling pathway of microRNA-155 in splenic lymphocytes BAX TNFRSF1B PMC11755087__F2 Schematic diagram showing insulin pathway in C SGK1 PMC4985526__F1 Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy TGFBR2 PI3 EGFR SMAD4 PTEN MTOR KRAS TGFBR1 PMC4044299__F4 TG2-mediated adhesion/signaling at the cell surface ARHA SRC CTNNB1 PMC4655955__F1 IPA prediction of the interactive network between the differentially expressed genes in the blood of triple negative compared to ER/PR+ breast cancer patients.Notes: Red – genes overexpressed; Green – genes underexpressed CXCL13 OSM TNFSF13 IL16 CCL26 IFNA2 PMC6566669__F1 Set of motor neuron proteins in the MAPK signaling pathway CDC42 MAX JUND RAF1 GRB2 PMC12068639__F2 TRIM proteins positively regulate innate immune signaling pathways TRIM14 TBK1 TRIM5 TRIM38 CGAS TRIM56 MAVS STAT2 IRF9 IRF3 IRF7 PIN1 TRIM21 PPP6C STAT1 TRIM25 TLR3 TRIM8 TRIM4 JAK1 TYK2 TRIM65 PMC9319447__F4 Identification, Characteristics and Function of Phosphoglucomutase (PGM) in the Agar Biosynthesis and Carbon Flux in the Agarophyte Gracilariopsis lemaneiformis (Rhodophyta) PTS GLA STS PMC4765060__F5 Canonical pathway analysis HTRA2 TRO FAS CAD TNFRSF1A CYCS KRAS CASR HRAS MAPK4 TNFRSF18 RELA CHUK RRAS DIABLO PMC4051169__F8 Mitotic roles of Polo-like kinase pathway PTTG1 FZR1 CDC20 APC WEE1 MYT1 POLE SLK PMC3415586__F2 Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: mechanisms and implications for immunity CD40 IRF4 PMC4931361__F1 Intrinsic and extrinsic apoptotic signalling pathways and points of therapeutic intervention BAX MCL1 FADD PMC6712451__F5 Subnetworks of special pathogenic pathways corresponded to different metastasis lesions EGF TNRC6A EGFR SMAD2 SMAD4 TGIF1 MYC ASH2L NCOR1 MLL2 NRAS KMT2B KMT2C THBS1 GATA1 ERBB4 AGTR1 TNRC6C KRAS RUNX3 HRAS RBL1 NRG1 HBEGF GFAP FZD4 RUNX1 AGFG1 ERBB2 APOB CFTR LEF1 RNF111 KAT2B PMC6109778__F3 Simplified ketone body metabolic pathway ECHS1 ACSF2 ACAT1 HMGCL BDH1 ACADS ACSS1 PMC11117695__F9 MAs protect IPEC-1 cells from H2O2-induced oxidative stress, inflammation and tight junction protein disruption via activating the Nrf2 pathway to inhibit the ROS/NLRP3/IL-1B signaling pathway NLRP3 NQO1 SFN TNF PMC4445654__F1 Atlas of tissue renin-angiotensin-aldosterone system in human: A transcriptomic meta-analysis EGFR RNPEP CTSG IGF2R REN AKR1D1 MME LNPEP ACE2 CYP21A2 CYP17A1 CYP11B2 AGTR1 HSD11B1 ENPEP DPP3 CTSA AGTR2 THOP1 CMA1 NLN HEL-S-130P CYP11A1 MGRA HSD11B2 KLNA1 AKR1C4 PMC1664647__F1 Schematic representation of the Fas pathway used in the mechanistic model FAS CASP8 CASP6 CASP3 PMC6918121__F1 Molecular composition, biogenesis, secretion, and uptake of the exosomes CD81 CD9 CD82 TSG101 CD63 PMC5343412__F7 Phylogenetic relationships of algae thiorredoxin-like ferredoxin domains ROS1 SRM PMC8082066__F7 SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease TET2 CDKN2A SIRT1 CDK4 PMC6280608__F6 The search page of prescription category as seen by submitting different names REN PMC2712749__F1 T cell receptor signalling canonical pathway obtained by IPA obtained in comparison MM8_PM8 IMP3 LAT PMC6280608__F2 The shared targets and pathways in Yu Ping Feng SHD LAT APP PMC9204954__F2 Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia TPH1 KYNU KMO AANAT GCA ASMT PMC4826167__F2 The role of the oncofetal H19 lncRNA in tumor metastasis HMGA2 EZH2 CTNNB1 PMC8196589__F1 Estrogens and Progestogens in Triple Negative Breast Cancer: Do They Harm? EGFR SRC PMC4837658__F1 Mouse T cell development FLT3 MYB LMO2 ETS2 LYL1 KIT IL7R ERG BCL11A GFI1 GATA3 ID3 RUNX1 ATL1 LEF1 HES1 PMC9513977__F5 Mechanism of abscisic acid regulation of wild Fragaria species in response to cold stress AGXT2 CHDH PIPOX HEL-S-61p PMC4696971__F2 NOD-Like Receptors in Infection, Immunity, and Diseases NLRC4 NLRP1 NAIP NLRP12 NLRP7 ATG16L1 NLRP3 NOD2 NLRP2 NOD1 TRAF6 MYD88 PMC2847023__F3 Vitamin D3-driven signals for myeloid cell differentiation - Implications for differentiation therapy NR1i1 EBP CD14 PMC8869775__F1 Assays Used for Discovering Small Molecule Inhibitors of YAP Activity in Cancers LATS1 MOB1A MOBKL1A LATS2 PMC8065657__F1 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor signaling in the regulation of apoptosis and metastasis of cancer cells STAT3 SPHK1 RIPK1 SRC TRAF2 RAC1 FADD PMC7199609__F2 Noncanonical functions of MAPK are emerging targets for BRAFV600E-mutated cancers CGAS PIR BRAF PMC5830368__F2 Current evidence for extracellular vesicle crosstalk in the homeostatic bone marrow microenvironment ANGPTL3 ANGPTL2 MSC TPO VCAM1 PMC12146543__F4 Integrative figure of molecular mechanism of traditional Chinese medicine (TCM) monomers-loaded exosomes for the treatment of cerebral ischemia and reperfusion (CI/R) BAX GAP43 GPX1 HEL-S-44 PMC12146543__F3 Integrative figure of molecular mechanism of traditional Chinese medicine (TCM) monomers-loaded exosomes for the treatment of neurodegenerative disease BAX ATG12 APP MTOR ATG5 PMC101920__F1 Late steps of AdoCbl biosynthesis in S ME2 APP PMC4641948__F2 Thrombin effects in endothelial cells involve S1P signaling SPNS2 SPHK1 RHO PMC6803569__F4 PVT1 participates in the downstream signaling pathway of c-Myc by regulating key molecules BAX HEL-S-133P HK2 BCL2 EZH2 TWIST1 CDK4 PMC7198842__F3 Chronic phase-CHIKV mediated joint pathology: in the joints, osteoblast cells (Bone-forming cells) are susceptible to CHIKV infection causing over-expression of IL-6 and RANKL and inhibition of osteoprotegerin (OPG) FRK TRAF6 CCL2 PMC3402799__F2 Networks generated by Ingenuity Pathway Analysis of the expression signature HEL-S-103 SMAD9 BMP8B SV2B SMAD2 SSTR5 DNAJC5 CRTC2 SLC6A1 IRAK2 NAGK SQSTM1 SLC6A9 SLC22A4 CORT SYT3 ACVR1B YWHAQ SSTR2 SLC17A1 VAMP1 AMH HTT PTGER2 CPLX2 CLCN3 CUL5 KCNJ15 IL6 TNF ASGR1 PDZK1IP1 NAALADL1 SLK SSTR3 VAPB GPR176 ABCC9 PTGER4 DACH1 MAP2K2 ASB2 PMC5719148__F1 Models for post-translational control of CHMP5 during T-cell development CHMP5 BCL2 PMC7920452__F4 Representation of the gastrointestinal signaling pathway CCL27 KLK5 CYP24A1 KRT14 CCL26 DAB2IP SOX2 KLK3 ERBB3 KRT6B RXFP3 CCNE1 ADRA2A FGFR4 DLL3 PMC4571319__F1 ERRs are key transcriptional factors that regulate cellular energy metabolism SLC2A12 ACO2 HEL-S-133P SLC2A4 UQCR10 HK2 SLC2A2 LDHB CS ACADM COX6A1 SDHB COX7A2 OGDH HEL-S-162eP ENO1 PMC11019495__F3 Recent advances of nanoparticles on bone tissue engineering and bone cells BMP3 BMP2 RUNX2 PMC7920452__F3 Representation of the dermatological signaling pathway MCAM KRT10 IF1IB1 CLSTN2 CXCL6 TACSTD2 TPSD1 EMP1 STAP2 NCR2 SLC52A1 TYRO3 SHBG CCL21 RGS4 ELF3 PMC5574901__F2 Most significantly relevant pathways and highly linked molecules (identified molecules from 17 preclinical studies which to explore the potential mechanisms of TLs for pancreatic cancer) relevant to the merged bionetwork ETS2 SP1 DDIT4 SMAD2 TGIF1 MTOR VEGFA MAP2 TNF ID3 DKK1 CHEK1 HEL55 MAP2K1 HES1 PMC8773784__F2 Nephropathic Cystinosis: Pathogenic Roles of Inflammation and Potential for New Therapies NLRP3 CXCL5 NLRP2 IL1B PMC6628503__F6 Proposed model of gga- miR-1306-5p regulation on activation of pro-inflammatory responses via targeting Tollip in chickens (Red arrow: up-regulation or down-regulation) IRAK1 IRAK4 IL1B MYD88 PMC8269128__F3 Hypoxia and Hypoxia-Inducible Factor Signaling in Muscular Dystrophies: Cause and Consequences MYOG MYF5 PAX7 PMC8658031__F4 Natural Bioactive Molecules: An Alternative Approach to the Treatment and Control of COVID-19 ADAM17 NLRP3 IL18 TRAF3 ACE2 PMC8269128__F4 Hypoxia and Hypoxia-Inducible Factor Signaling in Muscular Dystrophies: Cause and Consequences HEL-S-68p HK2 HEL-S-162eP BNIP3 BCL2 ENO1 HEL-S-30 PMC3642384__F2 Hypothetical evolutionary and functional relationship between Beta-catenin and nuclear transport receptors RAN LRP5 LRP6 CTNNB1 PMC9569508__F3 Drosophila as a Model Organism to Study Basic Mechanisms of Longevity RHEB HPD POLL POLI PMC9569508__F4 Drosophila as a Model Organism to Study Basic Mechanisms of Longevity tal-1 REL FADD PMC3893888__F4 Signal transduction pathways leading to increased HIF-1A protein levels RHEB TSC2 TSC1 PMC5622284__F4 Upregulated genes involved in apoptosis signaling at 1 day after a single dose of 2 Gy Fe ions BAD LTA TRADD MCL1 SP3 FES MYC PMC3724057__F7 MOMA analysis identifies double-gene knockouts in primary metabolism that funnel carbon toward DHA MAL CIT PMC5622284__F6 Irradiated ECs differentially expressed proteins after X-ray exposure involved in caveolar-mediated endocytosis and cell-cell adhesion CDH2 PFN1 PTPN1 ARF4 FLOT2 TLN1 CTNNB1 PMC7400218__F5 Cervical cancer in low and middle-income countries TLR4 IRF3 TRAF6 TNF RAC1 MYD88 PMC139817__F7 Regulatory interactions between SRF and TCF SRI GAL RHO PMC3498232__F9 Expression Profile in Rice Panicle: Insights into Heat Response Mechanism at Reproductive Stage MYB ERF GDI2 PRX PMC5622284__F2 Upregulated genes involved in cell cycle regulated processes at 7 days after a single dose of 2 Gy X-rays NDC1 AURKA ARF1 MYBL2 SMAD4 CCNA2 SKP2 PLK1 PTTG2 CCNB3 HDAC3 E2F4 E2F3 E2F6 HEL-S-1 MDM2 HDAC2 TFDP1 APC MPEG1 UBE2S SMC1A POLA2 MCM3 MCM2 ATR TGFB1 HMGA2 PCNA CKS2 CCNH CCND2 YWHAQ ATM SPAG5 CCNB1 HEL2 YWHAG CCND3 E2F2 ORC3 ORC2 RBL1 HDAC1 CCNE2 MEN1 PRKDC EP300 HDAC7 UBE2F YWHAZ PMC2635620__F2 Inhibition of each signaling molecules by natural products in insulin signaling PTEN MTOR SRC PMC6526932__F1 Targeting cancer vulnerabilities with high-dose vitamin C TF HEL-S-162eP PMC4365328__F1 HA precursors biosynthesis and main HAS2 regulation in SMCs OGT UGDH HAS2 GIP PMC4611209__F1 Sporadic traditional/CIN/suppressor pathway: sequential pathological stages and molecular events APC FAP PMC7981899__F1 Chemokines and their receptors’ roles in acute lymphoblastic leukemia STAT3 ZAP70 CXCR3 CXCL12 MMP9 ARHA MYC RAC1 CCL19 CCL25 CCR7 SRC NOTCH1 PMC5408584__F5 Fatty acid binding protein-1 (FABP1) and the human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias FAS NR1C1 NAAA RXRA FAAH PMC5408584__F4 Fatty acid binding protein-1 (FABP1) and the human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias FAS NR1C1 NAAA RXRA FAAH CPT2 PMC4235722__F2 Conservation between the Drosophila and the mammalian JAK/STAT pathway and their commonalities in inducing systemic and localized immune response and tissue growth IFNAR2 IFNAR1 SOCS3 IL6R PMC3782367__F1 Unfolded protein response (UPR) is activated in the autosomal dominant retinitis pigmentosa (adRP) retina and proposed to be a target for modulating the rate of retinal degeneration NRL CRX ATF4 RHO MTOR EIF2A TRAF2 PARP1 BIK PMC8897452__F6 Colorectal liver metastasis: molecular mechanism and interventional therapy CD44 MSI1 NUMB NOTCH2 NOTCH3 NOTCH1 PMC11552248__F1 Adhesin RadD: the secret weapon of Fusobacterium nucleatum TIGIT PCNA MMP9 PMC8897452__F7 Colorectal liver metastasis: molecular mechanism and interventional therapy STAT3 SMAD2 SMAD4 CXCR4 PMC4671959__F7 Mechanism of the Redox-Dependent Brf2 Blockade during Oxidative Stress and Carcinogenesis, Related to , , , , , , and During normal growth conditions (A) Brf2- and Nrf2-dependent transcripts are synthesized at basal levels HEL-S-8a BRF2 TBP PMC5454446__F2 ‘Eat-me' signals, phagocytic machinery and signaling pathways GULP1 STAB2 MEGF10 RAC1 MERTK PMC6964096__F4 Wiki pathway analysis of the differentially expressed proteins (DEPs) during rhesus hippocampal aging MYB NDUFB2 ND4L LAMB1 MRPL19 NDUFB4 NDUFB1 NDUFA3 NDUFC1 ND1 CES1 RPL12 RPS19 NTRK2 RPL23 RPS7 SDHD RPL35A SDHA TSC2 SDHB SOS2 RPS4Y1 SDHC GNG7 FGF12 GYS2 NDUFB9 RPS6KA1 GNB1 RPL18A RPLP1 RPL22 RPS5 ND4 RBL2 KRAS RPL4 RPS9 RPL26 RPL8 STXBP1 NDUFB6 RPS14 NDUFV2 PIK3C2G GNG12 NDUFA7 NDUFAB1 NDUFA10 NDUFS3 RPS11 COXFA4 PRKAA1 BCL2L1 GSTA4 RPL28 ND6 NDUFS6 RPS17 EIF4E1B ND3 ND2 RPL27A RPS21 GSTM2 RAB14 RPL7A GSTM5 RPL13 EIF4E HRAS RPL19 RPL23A GSTM3 RAPGEF1 RXRA LAMB2 ZNF183 NDUFS1 NDUFB8 NDUFV3 PTEN SLC7A11 NDUFS8 MTOR HEL-S-310 TNR RPLP2 RPL30 ITGAV NDUFS4 RPS16 RPS10 RPS13 INSR RPS3 RPL27 CHUK NDUFB7 NDUFB3 HSP90AB1 RPS6 RPTOR EIF4B NDUFC2 GNG10 RPL34 RPL15 FTH1 NDUFB10 FTL RPL13A RPL10A NFKB1 RPS28 GNB4 PRKAA2 RELA NFE2L2 RPS12 NDUFA2 RPS6KA3 PMC3653945__F6 Toll-Like Receptor -1, -2, and -6 Polymorphisms and Pulmonary Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis TLR1 JUN TIRAP IRAK1 TRAF6 FOS IRAK4 MYD88 PMC9588339__F5 Exploring Anti-Type 2 Diabetes Mellitus Mechanism of Gegen Qinlian Decoction by Network Pharmacology and Experimental Validation TRAF3 INS TRAF2 PMC6724083__F2 Hypothetical network of metabolism in F FH GLS CS PMC7770494__F33 International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function CDC42 TSC2 DCX CDK5 TSC1 NF1 PMC4224695__F3 Interactions of Acvr1b with other proteins in primary infection STAT3 ACVR2B PCBD1 HEL113 OPA1 SMAD2 IKBKE VTI1B PSMA2 TEP1 WWP1 CBL SHBG TUB PLRG1 HSF1 RS1 SNX1 SART3 SNX2 MDM2 ACVRL1 RBM3 NACA PMC7097117__F4 ISG15 in antiviral immunity and beyond TRIM25 USP18 HERC6 ISG15 PMC3311926__F1 Mitochondrial regulation of apoptosis BAX PMC5490213__F5 Representation of secondary metabolic pathway genes and tissue specific expression in response to MeJA and wounding in Bacopa monnieri IPP CAD HMGCR PMC7097117__F1 ISG15 in antiviral immunity and beyond TBK1 CGAS IFNLR1 MAVS IRF9 IRF3 IRF7 ARIH1 TRIM25 IFNAR2 TLR4 USP18 IFNAR1 CREBBP HERC6 ISG15 JAK1 TYK2 PMC5709539__F1 Emerging mechanisms underlying astrogenesis in the developing mammalian brain GFAP NEUROG1 CTNNB1 PMC5993950__F2 DYSREGULATION OF mRNA TRANSLATION AND ENERGY METABOLISM IN CANCER RHEB RPS6 EIF4B ELF2 EEF2 PTEN EIF4E PMC3743503__F8 GeneGo pathway map translation regulation of eIF2 activity HRAS DYRK2 EGF EIF2B5 EIF2S1 EGFR EIF2AK1 ELF2 GRB2 PMC8122391__F3 Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma STAT3 SYK BAD MDM2 PMC3743503__F9 Evidence for indirect influence of kinases on tau phosphorylation SP1 PLK3 EIF2AK1 CDK2 MAP2K3 PMC8059748__F1 PI3 kinase signaling pathway RHEB TSC2 BAD TSC1 PTEN MTOR PMC8100938__F3 Platelets orchestrate the prothrombotic immune response in venous thrombosis TF VWF HMGB1 IL18 IL8RB PMC4918253__F2 Canonical and noncanonical pathways of inflammasome activation.Notes: (A) Canonical inflammasome activation (canonical pathway) TLR4 IL1B PMC6365678__F7 CXCL16/CXCR6 interaction promotes endometrial decidualization via PI3K-PDK1-AKT-Cyclin D1 pathway TRO CXCR6 PRL IGFBP1 CXCL16 CCND1 PMC5419541__F3 Signaling Pathways for Permitting Cross Talk between WNT and GnRHThe shaded pathway represents the skeletal features of the canonical Wnt/Beta-catenin signal transduction pathway CDC42 JUN APC GSK3B SRC CTNNB1 PMC4918253__F1 Schematic view of the TLR4 signaling pathway.Notes: Upon binding of lipopolysaccharide (LPS) to the TLR4 complex (TLR4–LBP–CD14–MD2), TLR4 signals through MyD88-dependent and/or MyD88-independent pathways TBK1 TIRAP TLR4 CD14 IRF3 TRAF3 TRAF6 LBP IL1B MYD88 PMC8196612__F3 Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation TRPV1 GPR119 FAAH GPR55 PMC4835495__F2 Control of the FA pathway by SUMO and SUMO-like modifications ERCC1 ATR ATRIP PCNA RNF4 SENP6 FANCD2 REV1 BRCA1 RNF168 USP1 PIAS1 SLX4 PMC4383338__F9 Scavenger Receptor SREC-I Mediated Entry of TLR4 into Lipid Microdomains and Triggered Inflammatory Cytokine Release in RAW 264.7 Cells upon LPS Activation TLR4 CD14 IRF3 MYD88 PMC10836493__F3 Mechanism by which GPX3 is involved in maintaining the stemness of OCSCs in the TME CD44 TG SCD GPX3 PMC4113420__F4 PCNA and Msh2-Msh6 Activate an Mlh1-Pms1 Endonuclease Pathway Required for Exo1-independent Mismatch Repair PMS1 MSH6 PCNA PMC11810530__F2 IHD‐mediated pyroptosis occurs through canonical, noncanonical and alternative pathways FAS GSDMD NLRP3 TLR4 DFNA5 TRAF3 TRAF2 FADD PMC11810530__F1 Pyroptosis signalling cascade in IHD involves a series of events GSDMD NLRP3 TLR4 TRAF3 PMC12074965__F5 UDP-GlcNAc And CMP-Neu5Ac Synthesis In Mammary Epithelial Cells: In the cytoplasm, glucose (Glu) enters the cell via glucose transporter 1 (GLUT1) and is phosphorylated by hexokinase (HK) to form glucose-6-phosphate (Glu-6-P) NANP GNE AQP3 CMAS NANS PMC2778342__F2 Roles of the selected genes in the DSBR pathway BRIP1 RAD52 RAD50 RAD51 H2AX BRCA2 XRCC3 XRCC5 RAD21 BRCA1 CHEK2 ATM ZNF350 PMC3053440__F1 Toll-like receptor signaling pathway HEL-S-71 MAP3K7IP1 TIRAP TLR4 TAB3 IRF3 TRAF6 IRAK4 MYD88 PMC3423541__F2 Biological targets under investigation for treatment of SLE CD40 ICOS SYK IRF4 MTOR PMC11998019__F3 Exploration of Traditional Chinese Medicine Comprehensive Treatment of Triple Negative Breast Cancer Based on Molecular Pathological Mechanism LIF MTOR CTNNB1 LBR PMC6381741__F2 Differential expression of A UFD1L BAX ATF4 EIF2A PMC7933966__F6 Schematic underlying mediation mechanism of CRKL on glucose metabolism in hepatocarcinoma CRKL GSK3B PMC4651023__F4 Biophysical Approaches for Oral Wound Healing: Emphasis on Photobiomodulation JUN RELA SMAD4 FOS PMC8053626__F6 The mechanism of abnormal cholesterol transport in the 827G cybrids NR1C1 ABCG8 ABCG5 HMGCR RXRA PMC7851442__F2 DCs in cancer therapies P2RX7 CD40 CXCL9 FLT3 CXCR3 HMGB1 CGAS FLT3LG CXCL10 NLRP3 TLR3 TLR4 TREX1 PMC8283010__F3 Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation PLG MMP3 TNF CEBPB TRAF2 IL1B PMC7183768__F8 CREB signaling in neurons in response to granisetron treatment with the IPA molecule activity predictor GRB2 TBP PMC5328851__F2 Schematic diagram demonstrating the mechanism of action of perlecan and endorepellin in angiogenesis and autophagy PEG3 MTOR VEGFA PMC3695728__F2 Exploring mechanisms of FGF signalling through the lens of structural biology BAX BAD PLCG1 MARCKS GRB2 FOS PMC7010080__F2 NAD+ in cancer metabolic reprogramming SIRT3 HEL-S-162eP IL2 SIRT2 SIRT1 HEL-75 SIRT6 PMC12074965__F2 Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing HEL-S-19 GAL AQP3 PMC7010080__F1 Compartmentalized NAD+ metabolome in humans NRK SIRT7 NAPRT NMNAT1 SIRT4 SIRT5 NMNAT2 SIRT2 PARP1 SIRT3 SIRT1 NMNAT3 SIRT6 PMC7781229__F1 Mechanism and function of therapy-induced senescence ATR CDK6 PML ATM SUV39H1 CDK4 PMC10244546__F1 Potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma STAT3 BAX CD81 MTOR PMC9112071__F6 Chromosome-Level Genome of the Camphor Tree and the Underlying Genetic and Climatic Factors for Its Top-Geoherbalism IPP MVD MVK PMC11946974__F1 Bitter Taste Signaling Pathway TRPM5 CALHM3 CALHM1 PMC11200880__F1 Oxytocin signaling brain pathway KCNJ13 OXT RGS2 SLC12A5 RAF1 OXTR TLR4 EGFR MAPK7 TRPV1 MARK1 EIF2A PMC12095162__F3 NOD2 receptor signaling pathway MAP3K7IP1 RIPK2 TAB3 NOD2 PMC8442909__F4 Characterization of the Potential Role of NTPCR in Epithelial Ovarian Cancer by Integrating Transcriptomic and Metabolomic Analysis MX2 IRF7 GBP1 TNF OAS2 PMC9049047__F1 All roads lead to DSBs RAD51 BRCA1 BRCA2 PMC6669812__F2 Leptin binds to the LEPR and mediates multiple downstream pathways MMP7 STAT3 CAD LEPR GRB2 MTOR EIF4E PMC7775514__F1 Toll-like receptor 4 (TLR4) signaling in Alzheimer disease (AD) CDC42 HMGB1 TBK1 TIRAP CD36 APOE CD14 IRF3 TRAF6 MYD88 TREM2 PLCG2 TLR4 PMC7916307__F2 IAP-p53 axis is an essential regulator of a multitude of cellular pathways TF STAT3 NAIP BIRC5 COX2 EGFR PIAS1 KLF5 MDM2 XAF1 DROSHA HDAC2 PMC8998929__F3 Hippo Signaling in the Endometrium STK4 DKFZp686P11128 ARHA PMC8998929__F1 Hippo Signaling in the Endometrium FRMD6 STK4 PTEN MTOR PMC5360391__F6 Proposed hypothesis for the effect of melittin on formation of osteoclast-like MNCs NFATC1 TRAF6 IL1B PMC5665463__F6 Model for HCN4 function in establishing laterality HCN4 NODAL PITX2 PMC3733232__F1 TGFBeta-mediated signaling and transcriptional regulation in pancreatic development and cancer IFNG EGF IL1B PMC6943435__F1 Metabolic remodelling in lung cancer ACLY ALK HEL-S-133P HK2 EGFR GCLC PC KRAS PMC9049047__F5 All roads lead to Gaps RAD51 BRCA1 BRCA2 GAPT PMC3381938__F5 Alternative Macrophage Activation and Metabolism FAS ARG1 PMC3778921__F4 Integrative Analysis Reveals an Outcome-associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B-cell Lymphoma CDC2 CCND3 BAX FAS TFDP1 PERP RBL2 RB1 BCL2L12 MDM4 KDM6B CDKN2A CDK6 CDK2 BCL2 MDM2 TFDP2 RPL26 CDK4 PMC2771153__F9 Schematic presentation of a model of induction of beta cell apoptosis during viral infections TLR3 RNASEL OAS1 INS PMC10966608__F4 EcDNA in drug resistance EGFR DHFR BRAF PMC6858087__F1 Structural variability in the RLR-MAVS pathway and sensitive detection of viral RNAs MAVS TRAF5 IRF3 TRAF6 TRAF2 PMC5522741__F1 Aging is a complicated process, often characterized by increased ROS and inflammation FOXO1 FOXO3A SIRT1 PMC4076843__F2 Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders AHR CYP1A1 PMC3151428__F3 Suppression of anaerobic metabolism by p53 is mediated through multiple pathways HK2 PTEN TIGAR PMC12131575__F6 Schematic diagram showing the possible mechanism of noise-induced cognitive decline SGK1 FOXO3A BCL6 PMC9288732__F2 Crosstalk of organelles in Parkinson’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes VPS35 PINK1 LRRK2 PLA2G6 FLCN VPS13C MTOR ATP6AP2 PMC5912981__F1 GCN5L1/BLOS1 links acetylation, organelle remodeling and metabolism FBXO15 TFEB PMC8236063__F8 Mechanistic scheme of DNA-methylation-mediated RSPO2 regulating GCs proliferation, apoptosis and E2 secretion GC CCND1 CTNNB1 PMC5835171__F1 INNATE IMMUNE CONTROL OF ALPHAVIRUS INFECTION PARP10 PARP12 IFIT1 IFITM3 RNASEL OAS3 ISG15 PMC4382242__F2 Autophagy in cellular metabolism and cancer ULK1 ATG5 PMC9106601__F1 WNT and NOTCH signaling in human trophoblast development and differentiation APC NOTUM CTNNB1 PMC2766863__F2 Signalling crosstalk in B cells: managing worth and need SYK BCL10 BCR PLCG2 RELB BLNK CD19 LYN TRAF3 GRB2 REL TRAF2 PMC7411000__F1 Illustration of BPA on LC development HSD17B3 STAR SCARB1 NR3A2 CYP11A1 PMC3525024__F7 Schematic representation of canonical and noncanonical Hh signaling activation in MM PTCH1 SHH SMO CCND1 PMC8578498__F4 VGF as a biomarker and therapeutic target in neurodegenerative and psychiatric diseases VGF MTOR BDNF SYN1 PMC8701796__F6 Genome-Wide RNA-Sequencing Reveals Massive Circular RNA Expression Changes of the Neurotransmission Genes in the Rat Brain after Ischemia–Reperfusion GRM3 GNB1 GNAI3 GNB3 PIG59 HOMER1 GNG5 SHANK1 SHANK2 GNB4 TRPC1 PMC3628696__F5 Ingenuity Pathway Analysis (IPA) was performed with proteins where SUMO3 conjugation was 2- or more fold up-regulated in any gel slice TARDBP CBX4 PML SOX10 TCERG1 PIAS2 CHD3 NCOR2 HNRNPF SUMO1 SOX6 SUMO3 NXF2B RUNX1 NAB2 HNRNPUL1 ATN1 PMC10743592__F2 Presentation of the action of ghrelin on autophagy ULK1 MTOR ULK2 PMC10743592__F3 Presentation of association between apoptosis and necroptosis RIPK3 BAX TRADD MLKL BCL2 RIPK1 FADD PMC7395694__F9 Model for miR-214 regulation upon CC cell progression STAT3 PTK6 PMC5980154__F6 Schematic diagram illustrating how ɑ‐LA, via regulation of Grb2 expression, modulates different signalling pathways that participate in proliferation‐related stress responses TF EGF HGF GRB2 MTOR SRC PMC7260346__F5 De novo transcriptome analysis unravels tissue-specific expression of candidate genes involved in major secondary metabolite biosynthetic pathways of Plumbago zeylanica: implication for pharmacological potential INA COG3 PMC8741861__F10 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells APPL1 HEL-S-11 FSHR PMC4666507__F1 Described mechanisms involved in steroid hormone regulation of cancer stem cell populations KLF4 EGFR FGF9 TBX3 NOTCH2 BCL6 GATA3 PMC11640042__F1 Wnt signaling pathway APC LRP5 LRP6 RYK NLK CTNNB1 PMC8222790__F4 Cellular Metabolomics Profiles Associated With Drug Chemosensitivity in AML TH STAR IMPACT PMC11640042__F3 Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities GATA5 APC LRP5 LRP6 SFRP1 CTNNB1 TM4SF1 PMC11640042__F2 Wnt signaling regulates HCC biological behavior TRIM16 LIMA1 SOX11 FZD10 SOX15 TCF4 RUNX3 BEX1 EPHB2 CDK6 NLK TRIM54 ABCB1 MBD2 PMC1781473__F3 Exploitation of Eukaryotic Ubiquitin Signaling Pathways by Effectors Translocated by Bacterial Type III and Type IV Secretion Systems NEDD8 MAP3K7IP1 TAB3 PMC8046533__F3 KEGG Pathway analysis of IFNg protein in tuberculosis disease MADD CASP9 INA CD14 IL4 MYC PMC7527722__F7 Klebsiella pneumoniae ablates SUMOylation via distinct pathways in epithelial cells or macrophages NEDD8 TLR4 EGFR GSK3B SENP2 PMC5753009__F3 ATX-LPA axis promotes cancer-related inflammation LPA STAT3 JUN IL16 TERT HIF1A ATF2 ARHA MMP9 MTOR SRC PMC7246870__F5 Ingenuity Pathway Analysis (IPA) of five genes (CXCL10, FOS, UBE2N, IL1A, and TLR4) that are commonly regulated by both regorafenib and lenvatinib showed a close association with cell proliferation signaling pathways (red color) HEL-S-71 TLR4 IL1A FOS PMC5938431__F3 Interferon regulatory factor 1 inactivation in human cancer BRIP1 LOX CDK2 IRF3 ISG15 TYK2 PMC4008226__F8 A mechanism for integrated regulation of motility and adhesion in T cells and its role for transendothelial migration CXCL12 CXCR4 CD47 PMC4342183__F6 MAPK signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate MAPK signaling pathways MAX EGF JUND FAS EGFR CD14 TNF FLNA MEF2C NGF MAP3K7IP1 PAK1 NLK BDNF TRAF2 PMC3980725__F1 PI3K pathway inhibitors for the treatment of brain metastases with a focus on HER2+ breast cancer INPP4B EGFR PTEN IRS1 PMC7063406__F2 Epithelial and Epidermal barrier dysfunction: Various molecules involved in the signaling pathways shown in figure are maintaining the epithelial and epidermal barrier TTC7A IL16 EGFR GUCY2C IL6 TNF CCND1 MYD88 PMC4342183__F8 VEGF signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate the VEGF signaling pathway CDC42 CASP9 BAD COX2 SRC PMC3744771__F1 Inhibitory molecules and therapeutic targets within the Rhopathway HEL-S-62p LINGO1 RGMA EPHA4 ARHA PMC4342183__F7 Notch signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate the function of the Notch signaling pathway NUMB HES1 HES5 PMC5382886__F1 TLR4, MyD88 and TRAF6 down-regulation following glutamine administration in LPS-stimulated peripheral blood leukocytes of pancreatic cancer patients TIRAP CD14 TRAF6 MYD88 PMC3621284__F2 Proposed role of aPKCs in synaptic plasticity: At most CNS synapses, strong synaptic input leads to an activation of PI3K signaling and PDK1 activation thereby (1) thereby leading to mTORC1 activation PSD ELF3 EIF4E PMC3077378__F7 Multifaceted Intervention by the Hsp90 Inhibitor Ganetespib (STA-9090) in Cancer Cells with Activated JAK/STAT Signaling FLT3 EGFR PMC4342183__F2 Wnt signaling pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-181a-5p is a regulator of Wnt SIAH1 ROCK2 APC SMAD4 ARHA CTNNB1 BAMBI RBX1 SOST CER1 SKP1 NLK DAAM1 PMC4342183__F4 p53 pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-miR-181a-5p can regulate the p53 signaling pathway RFWD2 C6 BAX CASP9 ATR FAS SIAH1 CASP8 PERP PTEN MYC TSC2 PAF1 CASP3 ATM PIGS MDM2 PMC4342183__F3 Cell cycle pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-miR-181a-5p can regulate a number of important proteins that control the cell cycle CDC2 STAG2 DBF4 CDC20 PCNA STAG1 SMAD2 SMC3 APC GSK3B SMAD4 MYT1 PLK1 ORC3 SKP2 ORC2 CDK6 CDK7 E2F4 CDK2 MDM2 CDK4 PMC7057932__F2 Cellular signaling pathways associated with the mutated genes of the biliary tract cancer (BTC) cases ATR ERBB4 EGFR PIK3R2 BRAF PTEN CDKN2B MTOR MYC KRAS ARAF HRAS RB1 CDKN2A CDK6 NF1 PI3 CHEK2 CHEK1 ERBB2 ATM MDM2 CCND1 CDK4 PMC8777554__F2 Wnt/Beta-catenin signal transduction pathway in prostate cancer and associated drug resistance BAMBI RNF43 APC GSK3B CTNNB1 PMC8777554__F1 Wnt/Beta-catenin signal transduction pathway in prostate cancer and associated drug resistance INVS ROCK2 ARHA DAAM1 PMC8358957__F2 Endocannabinoid system – current implications for drug development DAGLA DAGLB NAAA ABHD6 FAAH PMC4741978__F3 SNP-SNP interaction analysis of NFKB signaling pathway on breast cancer survival NFKB1 NFKB2 TRAF3 TRAF2 PMC7068866__F6 Metastasis prediction: optimum centered Bayesian network found CXCL9 HEL107 JMJD6 HECW1 SMAD9 EED FAS RAB7A RIOK3 CDCA4 ZDHHC1 P4HA2 PML FRAS1 YY1 KLF14 SHANK1 PRDM11 DNAAF3 SPP1 MASP1 ZNF550 RBMS3 COLEC10 ERAP1 NAV1 ITPRIPL2 ZNF428 SH3PXD2B ZNF75D KCNS2 VSX1 ZNF597 PMC6201246__F6 Overview of current understanding of the pathogenesis of HIT VWF HEL-S-62p ELL PF4 PMC6273515__F3 Bound sulfur activates the nuclear factor erythroid related factor 2 (Nrf2) system through a structural change of Kelch-like ECH-associated protein 1 (Keap1) and promotion of the AKT/phosphoinositide 3-kinase (PI3K) signaling pathway DAO PMC8638743__F2 Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses MDM4 PTEN MDM2 MTOR PMC8638743__F1 Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses RHEB TSC2 RICTOR TSC1 PTEN MTOR DEPTOR PMC5942188__F1 Review of craniofacial and dental findings of the RASopathies SOS1 NF1 RIT1 BRAF CS PMC10501637__F5 PPI network analysis of total DEGs in ELMOD3mut and ELMOD3corrected iPSCs HEL113 CCK AVPR2 GABRB2 NMU CHRM3 NEFL EFNA1 PCSK9 CCKBR EPHA8 GRM4 CX3CL1 APLN POMC CNR1 XCL2 EPHA3 KCNMA1 SHC3 KNG1 GRPR MYL7 ATP2B2 ADM RLN2 CXCL2 ANXA1 CXCL6 SPP1 GNA15 GABRA3 EFNA3 GALR1 IGFBP5 EDN1 FAM20A ATP1A4 RS1 EDNRB CALCA SCT BDKRB2 PMC3342043__F1 TLR2 signaling STAT1 TLR1 TIRAP IRF2 IRAK1 IRF1 IRF3 IRAK2 IRF7 TRAF6 IRAK4 MYD88 PMC6689183__F8 Dropwort extract exerts broad anticancer effects on MPM cells affecting cell proliferation, viability, migration, metabolism and in vivo tumor growth of MPM cell lines MCM7 ANKRD1 NUAK1 TEAD2 TEAD3 MTOR TEAD4 CTNNB1 PMC2723150__F1 Eukaryotic gene expression is controlled by multiple mechanisms, and its regulation is central for physiological responses to extracellular and intracellular signals NNAT ND1 RAN NANP CALY MAL INS OTP PMC3159004__F2 TLR-independent innate immune responses C2 IRF3 NFATC1 PMC5370040__F1 Tumour-derived exosomes as a signature of pancreatic cancer - liquid biopsies as indicators of tumour progression CD81 CD9 CD151 CD63 PMC6172067__F5 Prognostic biomarkers in clear cell renal carcinoma HEL113 CD36 TNFSF6 NTRK2 ITK VEGFA SPI1 PMC5983591__F1 Growth hormone releasing peptide (GHRP)-peroxisome proliferator-activated receptor-gamma (PPARG) pathway in lipid and energy metabolism ABCG1 CD36 APOE ABCA1 INSIG1 PMC4118128__F9 The proposed model for the regulation of the IRS-1-PI3K-mTOR pathway by PRCP and PREP PRCP MTOR IRS1 PMC7820188__F2 Wnt signaling, structure and activation: Wnt signaling is activated when glycoprotein ligands of the Wnt family bind Frizzled transmembrane receptors located at cell membrane level CDC42 APC RHO PMC9404549__F9 Salvia chinensis Benth Inhibits Triple-Negative Breast Cancer Progression by Inducing the DNA Damage Pathway FANCD2 ATR RAD51 H2AX ATM PMC2642591__F1 Retinoic acid dependent regulation of immune responses by dendritic cells and macrophages HEL-S-53e APC HEL-S-4 FOXP3 ADH5 PMC2254474__F1 P2Y receptor-mediated signalling cascades in C6 cells JUN GFAP ARHA GRB2 PMC6687752__F7 CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3 HRAS STAT3 SAP18 CXCL1 IL8RB PMC4800795__F10 FAF1 action on the innate-immunity signaling pathway TBK1 MAVS IFIT1 IPO5 FAF1 IRF3 MX1 ISG15 PMC4762492__F1 PI3K/AKT/mTOR signaling pathway and examples of drugs targeting each of its components.Note: RSK, 90 kDa ribosomal protein S6 kinase RHEB RPS6 BAD INPP4B EGFR PTEN PMC2818872__F8 Ras signaling in early B cell development SOCS2 SOCS3 CXCR4 PMC11659631__F8 Mechanism of GGO inhibited cervical cancer cell proliferation and angiogenesis SPRY2 MMP2 PTEN MMP9 MTOR PMC10296830__F1 The Hippo pathway and YAP/TAZ mechanosignaling LATS1 LATS2 MAPK7 ARHA ARHGAP29 MAPK6 PMC3875462__F1 Regulation of the mTOR signaling pathway STRADA RHEB TSC2 TSC1 PTEN EIF4E PMC3659299__F4 Scheme depicting the current knowledge on PAC1-mediated signaling cascades resulting in a variety of neuronal outcomes HEL164 NGF SRC UNK PMC4013678__F2 Bayesian Brain Immune and Microglia Module TCIRG1 SYK TNFRSF1B PYCARD PARVG TNLG7A HLA-DOA RBM47 ADAM28 PTPRC CTSS GRN MYO1G GPX1 TGFBR1 DOCK2 HLA-DRA CD74 TYROBP LILRA2 CD33 IL13RA1 PTGS1 HLA-DRB4 MFNG CSTA LAT2 CCR1 HLA-DMB HEL-S-43 APOC1 ARHGAP30 SERPINA1 PTPN6 ARPC1B SLC15A3 HLA-DMA RUNX1 CMTM7 WDFY4 FPR1 PBR CMTM6 LYN REL IL10RB PMC5652852__F1 Chromosomal instability and acquired drug resistance in multiple myeloma ERCC1 ERCC2 CDC20 CCNE1 APC PMC4461483__F4 Possible role of Naa10 in cellular hypoxia ACLY ARD1A PMC10943832__F2 Metabolic pathway of tryptophan (Trp) CYP2E1 KYNU HAAO AFMID PMC10943832__F5 AhR signaling pathway TF TBL3 RBX1 DDB1 IL10 NLRP3 KLF6 CUL4B AHR AHRR SRC CTNNB1 PMC3469769__F2 Multiple roles of COUP-TFII in cancer initiation and progression NR1H4 APOC3 NRP1 PCK1 LIPC ALDH2 APOA4 NR1C1 RBP2 NR2F2 NPPA SHBG RARB KDR NR5A2 PMC5641361__F4 Cell signaling pathway scheme of metabolic alterations due to Zika virus infection MME CPA3 MGRA CTSA MTOR ACE2 PIKFYVE PMC8220449__F7 Schematic diagram depicting the effect of TMJ-12 on the PI3K/AKT signaling pathway leading to the induction of apoptosis and cell cycle arrest in BPH-1 cells BAX BAD PTEN MTOR EIF4E PMC7330089__F8 Regulatory model of the MBW complexes for juvenile red fading in sweetpotato leaves MYB HEL-S-62p C2 PMC5404519__F1 Biosynthetic pathway of the major phospholipids in bacteria PGP PSD C1S PMC5992185__F4 Molecular structure, posttranslational modifications, and protein–protein interactions of the Ski and SnoN proteins AURKA JUN GATA1 SIX1 SMAD2 PML SMAD4 FHL2 SKI TEAD4 HDAC3 LATS1 HDAC1 LATS2 HIPK2 TEAD2 NF1 TEAD3 PIAS1 RB1CC1 SMURF2 EYA3 SIRT1 GLI3 PMC4467754__F14 Scheme of possible mechanisms by which AT-101 enhances the anticancer activity of CDDP in NSCLC STAT3 MYB EGR1 PAX5 PAX8 HLF PMC5641207__F1 Single-cell genomic analysis of head and neck squamous cell carcinoma EGR1 SP1 RELA SMAD4 VEGFA MYC PMC11810091__F7 Changes in mucosa branched N-glycosylation impacts gut microbial balance, leading to an intestinal inflammatory response MGAT5 FUT2 NOD2 PMC3291999__F3 MTOR signalling pathway (see text for details) RHEB TSC2 TSC1 PTEN IRS1 EIF4E PMC5992185__F5 Ski and SnoN protein stability by the TGFB/Smad signaling pathway SMAD2 APC SMURF2 SKI PMC8399070__F1 Nanocarriers as a Tool for the Treatment of Colorectal Cancer BAX FAS FADD PMC5342415__F3 Meta-dimensional data integration identifies critical pathways for susceptibility, tumorigenesis and progression of endometrial cancer MGST3 KLKB1 NCF2 MGST1 PIK3R1 CR2 PTPRC SMPD1 PLA2G2F RB1 GTF2F1 SLC23A2 F10 RRM2B TBP ACOX1 GSTM2 TFDP1 PLG SNCA VAV1 HEL-S-78p COL2A1 TSC2 LAMB3 FGA WASF1 GPX7 ITGB5 GTF2F2 PRKAR1B TAF10 TP73 ATR SGPL1 GSTT2 BRCA2 F7 SGMS2 DEGS2 CDKN2D GGT7 TNR PLA2G2E BLM GP1BB CCND2 F2R CHEK2 APP CCNB1 CERK SMS AKAP8 TAF4B NFATC1 CD47 RPA1 PMC5706051__F7 Diagram depicting epinecidin-1-mediated degradation of MyD88a and downstream events TLR4 IRAK1 IRF3 TRAF3 TRAF6 IRAK4 MYD88 PMC3908416__F8 Panx3 signaling pathways inhibit osteoprogenitor cell proliferation and promote cell cycle exit GSK3B LRP5 LRP6 PANX3 CTNNB1 PMC3616489__F3 Emerging roles of E2Fs in cancer: an exit from cell cycle control CDK6 E2F4 E2F5 CDK4 PMC3596655__F8 Proposed molecular mechanisms of the anti-inflammatory effects of allosteric SHIP1 activation BTK PI3 PTEN PMC8150642__F1 KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism JUN HIF1A MTOR MYC FOS PMC5992185__F2 Regulation of Ski and SnoN expression by different mechanisms HGF SMAD2 SMAD4 BMP7 NODAL SKI PMC8150642__F2 KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism ACLY GOT2 FAS ACSL3 GLS HEL-S-133P HEL-S-5 HEL-S-32 ASCC2 HEL-S-26 PMC5992185__F1 Regulation of the TGFB/Smad signaling pathway by Ski and SnoN SKIL SMAD2 SMAD4 SKI PMC6079274__F2 JAK2 protein in intracellular crosstalk GRB2 MTOR IRS1 PMC8772740__F6 Konjac Ceramide (kCer)-Mediated Signal Transduction of the Sema3A Pathway Promotes HaCaT Keratinocyte Differentiation NRP1 ARHA RAC1 PMC4898659__F3 Signalling pathways modulated by NF1 RHEB TSC2 TSC1 NF1 MTOR PMC10215719__F7 Proposed mechanisms of the effect of Ptn overexpression (A) and the pharmacological inhibition of RPTPB/ζ with MY10 (B) on some of the principal signaling pathways implicated in ethanol and/or LPS acute response in adolescent mice FYN PTN ALK TLR4 PMC5545101__F3 mTORC1 signaling and the metabolic control of cell growth CAD OMP ATF4 MYC PMC8533248__F2 Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs KLF4 COL1A1 MAP3K7IP1 IL13RA1 SMAD2 LRP5 SMAD4 LRP6 MTOR JAK1 COL3A1 CTNNB1 PMC2562939__F1 The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin DPH1 DPH2 DPH3 DPH5 PMC3656947__F3 PKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells RELB PPP3CC TNFRSF10A SERPINB8 MFHAS1 ALDH1A3 TNFAIP2 STK10 ARID2 NFKBIZ dik ADAMTS9 G0S2 IL6 TNF VGLL4 SCIN B3GNT5 PLK3 SLC2A6 RELA HAS2 RNF19B REL ABTB2 EHD1 CLIP2 PMC5972910__F11 Putative role of Wnt signaling pathway during BoHV-1 latency-reactivation cycle AKT3 WIF1 CTNNB1 PMC11107893__F1 Molecular targets and therapeutic interventions in non-small cell lung cancer treatment ROS1 CDK6 ALK EGFR BRAF MTOR KRAS EML4 RET CDK4 PMC7735419__F4 Image of the potential transcription factors of GPX8 SCRT1 SOX17 SCRT2 ZNF732 HIC1 CRX SOX12 CDX1 IRF7 TCF4 IRF4 SATB1 GPX8 TCF3 SRY FOXC1 SPIB SOX18 ATF1 ZNF407 PMC9006080__F5 Molecular Signatures of Mitochondrial Complexes Involved in Alzheimer's Disease via Oxidative Phosphorylation and Retrograde Endocannabinoid Signaling Pathways ATP6V0E1 GPR83 TNFRSF1A PPP3R1 PSMB2 CHRM3 CALML4 PPP3CA NDUFAB1 PSMD1 RYR3 ATP6V1C1 ATP6V1C2 TUBA4A TUBB2A PSMD6 FZD9 SNCA BACE2 TUBB SDHA HEL-S-66p SDHB CDK5 RTN3 RTN4 UQCRFS1 ATP6V1E1 ADCY1 PMC8435904__F5 LncRNA GAS5 Competitively Combined With miR-21 Regulates PTEN and Influences EMT of Peritoneal Mesothelial Cells via Wnt/Beta-Catenin Signaling Pathway PTEN CTNNB1 PMC9016245__F3 Mitochondria signaling pathways in allergic asthma PRMT1 SMAD2 PMC7735419__F8 Proposed molecular mechanisms of GPX8 in gastric cancer cells GPX8 APC GSK3B FOXC1 CTNNB1 PMC6644836__F4 Partial diagram of the “Signaling by SCF-KIT” pathway showing the feedback loop that generates the “p-STAT dimers” complex annotated in Reactome KIT PTPN11 VAV1 GRB2 PMC12240780__F5 LLPS in mutant tumor suppressor genes driving carcinogenesis SPOP APC NF2 CTNNB1 PMC12240780__F4 LLPS in tumorigenesis due to FOs HDAC1 SOS1 GRB2 HDAC2 SS18 PMC12240780__F3 LLPS regulates cellular phenotypes ATG101 ULK1 ABLIM1 PMC4633218__F7 Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet FAS ADIPOR2 SIRT1 PMC7910492__F8 Mechanism for the synergistic effects of BKM120 and olaparib on the death of MDA-MB-231 cells RAD52 RAD51 BRCA1 FOXO1 BRCA2 PARP2 SSB PARP1 PMC11921546__F2 LPS-TLR4 mediated signal transduction pathway SYK TBK1 TRPM7 TANK CD14 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 SIL1 MAP3K7IP1 TLR4 LBP PMC5256158__F5 Schematics of multitargeted actions of T1AM on metabolic and steroidogenic pathways PPARG TG GPAM FAS STAR MAL SREBF2 ADFP CIT PMC6053305__F10 PERK signaling pathway in modulating skeletal phenotype SOX9 FGF21 ATF4 PMC139401__F2 TLR signal transduction pathways STAT1 TIRAP TLR4 MAL TRAF6 IL1B MYD88 PMC6407245__F1 Nongenomic and Genomic actions of Thyroid hormone and thyroid hormone receptor ME3 STAT3 NCOR1 MTOR SRC NR1A2 THRA PMC8449055__F2 New strategies for targeting kinase networks in cancer DDR1 AXL EGFR BRAF PMC2820927__F3 Model illustrating the dynamic overlapping phases of early events of KSHV infection in endothelial and fibroblast cells and KSHV-induced signal pathways and their role in infection RHO SRC PMC3215943__F4 MOLECULAR MECHANISMS OF FEAR LEARNING AND MEMORY EGR1 NPAS4 ARC MTOR PMC2875805__F10 Cartoon illustrates genomic and nongenomic actions of VDR signaling in inhibition of human CYP7A1 gene transcription in human hepatocytes NR1i1 NCOR1 RXRA SRC PMC3215943__F3 MOLECULAR MECHANISMS OF FEAR LEARNING AND MEMORY EGR1 ARC MTOR BDNF PMC6537015__F8 The proposed mechanism underlying TRPA1-mediated CMF transdifferentiation and cardiac fibrosis after MI injury ACTA2 POSTN TGFBI TRPA1 PMC5045229__F4 Cabozantinib provides dual inhibition of MET and VEGFR2 preventing the MET pathway from acting as an alternative pathway in the development of VEGF TKI resistance BAD HGF MDM2 MTOR PMC2219551__F7 Signaling Pathway Involved in Neutrophil Elastase–Stimulated MUC1 Transcription MUC5AC TGFA SP1 EGFR DUOX1 PMC8413298__F9 Many gCIS function on the same pathway as the oncogenic driver responsible for tumor initiation HGF MAK PIK3R1 PPP2CA SOCS3 SH2B2 LATS1 RHEB CD44 UBR5 TRIM24 SOCS5 EXT2 SP3 CREBBP RYBP MDM2 KDR GRB2 SH2B1 LPP GAB2 PMC5795421__F2 Human micro RNA (miRNA) pathway DGCR8 DROSHA PMC2713330__F1 Innate Immunity in the Lungs TBK1 TIRAP TLR9 CD14 IRAK1 TLR5 IRF3 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 IL1B PMC8097099__F1 SUMOylation Wrestles With the Occurrence and Development of Breast Cancer RANBP2 SUMO1 SUMO3 SUMO2 SAE1 PMC4338202__F5 Whole Transcriptome Analysis Using Next-Generation Sequencing of Sterile-Cultured Eisenia andrei for Immune System Research TIRAP IRAK1 MYD88 PMC4499885__F5 Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells STAT3 EGF EGFR JAK1 TGFBR1 PMC7012612__F4 IGF1 signaling pathway is under increased evolutionary constraint in long-lived, large-bodied mammals BAD PRKD1 RAF1 SHC1 SOS1 PXN PRKCZ IGF1R RHO NCK2 GRB10 PI3 PDPK1 SRC HEL2 CRKL PTPN1 PTPN11 RAC1 IRS1 HRAS CRK IGF1 GRB2 YWHAZ PMC4083591__F1 Type I Interferon in the Pathogenesis of Lupus CGAS TNFAIP3 C2 PDC IRAK1 STAT4 IRF7 TREX1 ATG5 TYK2 PMC7142266__F3 Functional domains of BRCA1/2 protein with pathogenic mutations BARD1 BRIP1 RAD51C BRCA1 SCD BRCA2 ATM PMC7142266__F2 Mechanisms of tumorigenesis attributable to FA mutations FANCE FANCD2 ATR FANCF BRCA1 CHEK1 FANCL FANCA FANCC PMC8171373__F1 Hijacking the Pathway: Perspectives in the Treatment of Mature T-cell Leukemias BAX MCL1 HEL-S-171mP BCL2 ATM ITK MDM2 PMC5589605__F4 Systematic analysis of coronary artery disease datasets revealed the potential biomarker and treatment target TCF3 CEBPA LEP ASL PADI4 FOLR3 ARG1 PMC6467965__F2 Schematic presentation of the cytotoxic pathways, induced in cancer cells by the complement C5b-9, the counteractive cellular resistance mechanisms, and postulated approaches to overcome this cancer evasion RIPK3 CD59 HEL-S-62p MLKL CD46 CD55 PMC8107084__F6 MiR‐155 promotes colitis‐associated intestinal fibrosis by targeting HBP1/Wnt/B‐catenin signalling pathway APC CTNNB1 PMC5882217__F3 Hippo pathway and cross-talk with other signaling pathways in mammals LATS1 OGT LATS2 AMOT APC RHO NF2 NLK AREG VGLL4 CTNNB1 PMC5133786__F1 Proteolytic processing of the amyloid precursor protein (APP) and its modulation by vitamins A, D, E, and K VIT IDE ADAM9 APP PMC3829599__F1 mTOR pathway signaling cascade RHEB ELF4 TSC2 GRB10 TSC1 IRS1 PMC6997601__F2 MVA pathway and the synthesis of astaxanthin and ergosterol in X IPP MVD MVK PMC6743006__F3 Exposure to high fat diets over time, enriched in saturated fatty acids, would promote the glial activation and an increased mitochondrial oxidative stress NR1C1 APP IRS1 PMC3277712__F1 Importance of cytokine signalling for CD4+ T-cell differentiation IL6 FOXP3 GATA3 PMC3899195__F6 ZNF365 promotes stalled replication forks recovery to maintain genome stability CDC20 APC PMC8844036__F8 Schematic diagram of sEVs DNAJB8 based signaling pathway in CRC L-OHP resistance PGP PMC7842149__F3 Angiotensin II and T lymphocytes activation during COVID-19 best scenario TMPRSS2 TH ADAM17 PMC9562224__F11 HOCI Probe CPP Induces the Differentiation of Human Dermal Fibroblasts into Vascular Endothelial Cells through PHD2/HIF-1A/HEY1 Signaling Pathway VWF KDR PMC11951404__F1 Transcriptional and posttranslational regulation of CONSTANS (CO) CO acts as the core regulator of the photoperiod response pathway to integrate external and internal signals into the photoperiodic flowering pathway RFWD2 CRY2 PMC7842149__F1 Roles of the RAAS in health and COVID-19: A better and worse scenarios—(A) Basal angiotensin system TMPRSS2 ADAM17 GRAP ACE2 PMC4384112__F3 IFN-induced signaling through the JAK-STAT pathway IFNAR2 IRF9 IFNAR1 PIAS1 JAK1 TYK2 PMC9773994__F3 Edible plant extracellular vesicles: An emerging tool for bioactives delivery BAX GSK3B PTEN PMC10215861__F3 Roles of RONSs during skeletal muscle pathologies IGF1 ULK1 DMD MTOR IRS1 PMC10975450__F2 Signaling pathway molecular mechanisms: Several signaling pathways play a major role in tissue development and thus in PSC differentiation, specifically into cardiac tissue SMAD1 DKFZp781O1323 SHC1 SMAD2 SMAD4 NODAL MTOR CTNNB1 LATS1 LATS2 F3 SHH SMO APC DHH LRP5 IHH LRP6 IGF2 IRS1 FOXO1 PTCH2 FOXO3A PTCH1 GLI3 PMC6638919__F10 NADPH oxidase 4 mediates TGFB1/Smad signaling pathway induced acute kidney injury in hypoxia SMAD2 SMAD4 NOX4 PMC2702690__F9 Molecular Mechanisms of HIF-1A Modulation Induced by Oxygen Tension and BMP2 in Glioblastoma Derived Cells STAT3 BMP2 MTOR PMC3690774__F5 Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17Beta-estradiol in embryonic zebrafish MAP1B ATOH1 TRPV1 SMO PROC IFT172 PMC5925819__F2 CDP-DAG and Kennedy pathways CDS2 PSD CDS1 PMC10341943__F3 Role of the Notch pathway in cell-fate decisions in the somite PAX3 LBX1 PECAM1 PMC7477297__F3 Hypothetical OT signaling pathways targeting the nucleus and mitochondria in the cardiac cells STAT3 PGC GSK3B EEF2 GATA4 MEF2C PMC8299209__F2 Pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway STAT3 FYN ROR2 ARHA NLK CTNNB1 PMC8299209__F1 Pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway APC CTNNB1 PMC5562273__F2 A simple answer to complex questions: C. elegans as an experimental model for examining the DNA damage response and disease genes TF ERCC1 XPA DDB1 XPC PMC4172058__F1 Schematic diagram depicting the most representative signaling of the PI3K/AKT pathway TSC2 BAD RICTOR TSC1 GSK3B PTEN MTOR CCND1 PMC6269490__F1 Roles of CO in metabolic homeostasis FGF21 ATF4 EIF2A SESN2 PMC3177572__F6 Schematic diagram summarizing the bidirectional role of PIAS1 in regulating JNK-dependent oxidative stress responses SUMO1 SENP1 PIAS1 PMC8299209__F3 Pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway JUN TAB3 IRF3 TRAF3 NLK TRAF6 IRAK4 IL1B CTNNB1 PMC9578543__F8 Enhanced Apoptosis in Choroidal Tissues in Lens-Induced Myopia Guinea Pigs by Activating the RASA1 Signaling Pathway BAD PMC4368378__F1 PINK1-Parkin signalling USP30 PINK1 USP15 PGAM5 PMC7222508__F6 Network of 145 candidate genes with main drug metabolism pathway genes NCOR2 ADAR PTPRO MCC SOS2 APC CTSA MTOR DROSHA PTPRG PICALM PMC10343931__F4 Possible mechanisms by which exercise upregulates NAD+ to improve mitochondrial autophagy POC1A SLC25A51 NMNAT2 SIRT1 PMC6913091__F3 Pushing the envelope: LPS modifications and their consequences TLR4 PAG1 MYD88 PMC5778108__F1 Canonical and non-canonical NFKB signaling in humans LTB CD40 LTBR BCR RELA RELB PMC8417591__F2 Extracellular Vesicles in Sickle Cell Disease: Plasma Concentration, Blood Cell Types Origin Distribution and Biological Properties TF NLRP3 TLR4 VCAM1 PMC4439968__F1 Toll-like receptor 4 signaling pathway HMGB1 TLR4 TRAF6 MYD88 PMC6684943__F1 Regulation of C/EBPB in MDSCs NOS2 COX2 ARG1 CEBPB PMC8540846__F1 Molecular Targets and Promising Therapeutics of Triple-Negative Breast Cancer BRCA1 EGFR BRCA2 F3 DUSP4 PTEN MTOR PALB2 PMC3690116__F1 Schematic model of FGF-2 and FGF-18 signaling pathways in articular cartilage and IVD FGFR1 FGFR3 COL10A1 RUNX2 UNK PMC2841329__F1 Model for the role of ΔNp73B in the DDR RAD50 H2AX ATM MDM2 PMC4354324__F3 Multiple promising targets for regulating cancer metabolism ACLY FASN ME1 PMC2781055__F3 Ingenuity pathway analysis (IPA) of microarray data generated several genetic networks PMCH STAT3 TRH NPY1R CCR2 MAP2 GH1 FST HSF1 PAX8 APP SH2B1 GHR UNK FCGR2A RAB27A HOMER1 PYY NPFFR2 ERBB3 CRK KISS1 PRL NPVF EDNRB MAP2K1 CXCR4 CCL20 PMC11546116__F3 Vascular regeneration after MI DLL4 MSC NOTCH1 PMC11546116__F2 Regulatory mechanisms involved in myocardial regeneration CDC2 NRG1 TBX20 ERBB4 E2F2 E2F4 MSC ERBB2 CDK2 CDK4 CTNNB1 PMC2732336__F1 Outline of the major cell surface receptor-mediated signaling pathways important in the differentiation, survival, and function of melanocytes CDH2 BAD GSK3B PTEN MTOR CTNNB1 PMC4630409__F1 Schematic overview of TLR and NLR signaling pathways TLR3 TLR4 TLR9 TLR8 NOD2 TLR5 IRF3 IRF7 TLR7 MYD88 PMC4659591__F10 MicroRNA Profiling Implies New Markers of Gemcitabine Chemoresistance in Mutant p53 Pancreatic Ductal Adenocarcinoma CDC2 BAX BAD CDK6 IGF1 BNIP3 CDK2 IGF1R MYC IGF2 CDK4 PMC10985960__F10 Hypothesis of possible IFN-I signaling pathway regulatory mechanism based on our findings in PD NFATC2 IRF9 TNF PMC9027317__F10 Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway FAS NR1C1 KEAP1 TLR4 MYD88 PMC4379939__F1 As yet unknown side of DC secretion post-TLR activation, and trafficking molecules currently identified in DC function SNAP23 SEC22B RAB11A VAMP3 MAL STX4A TRAF6 STX3A VAMP8 MYD88 PMC3101238__F7 Omeprazole Inhibits Proliferation and Modulates Autophagy in Pancreatic Cancer Cells PUDP OMP PC PMC9334696__F2 Biopolymeric nanoparticles based effective delivery of bioactive compounds toward the sustainable development of anticancerous therapeutics BAX RHO PMC6080592__F3 Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data HEL-S-103 EGF TAPBP VASP PRODH2 OTC C1QB CTSS GNGT2 COL3A1 PIN1 DAO PRKCB EZR PLAT FYN CD74 F2R THBD A2M MMP2 HEL-S-32 CYBA BIRC3 LPL BAX LIMK2 CASP12 CXCL16 INPP5D LDHB PRNP VAV1 ITGB3 ITGA2B PDE1A ITGA1 FABP2 PDGFRA PTPRE PRODH HAGH CYBB PMC9123807__F1 Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents IRF1 ISG15 PMC9693393__F2 DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve ATR ATM AMH MTOR PMC5384128__F1 Adaptive resistance and innate resistance STAT3 ALK EGFR PTEN MTOR PMC7257252__F5 Fibroblast Growth Factor–21 ameliorates hepatic encephalopathy by activating the STAT3-SOCS3 pathway to inhibit activated hepatic stellate cells STAT3 EGF FGF21 CCL5 PMC4963952__F5 Regulation of genes of Cell Cycle pathway during senescence induction in HFF strains CDC2 DBF4 CDC20 PCNA BUB1B CDC6 ORC6 SMC3 MAL CDKN2B CCNA2 PLK1 RBL1 PKMYT1 MAD2L2 PRKDC CDC45 TTK CHEK1 CDK2 CCNB1 PMC5653149__F15 Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer PPIC NOS2 SLCO3A1 TXNIP APOE PSMB10 PTGS2 PMC11604586__F1 Progress and perspectives on BMP9-ID1 activation of HIF-1A and VEGFA to promote angiogenesis in hepatic alveolar echinococcosis HDAC7 MTOR VEGFA ID1 PMC9693393__F1 DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve TSC2 TSC1 KIT PTEN LAT2 PMC4963952__F6 Regulation of genes of cell cycle pathway during senescence induction in MRC-5 strains GADD45G CDC20 PCNA E2F2 OPN4 ORC6 MYT1 MYC ORC2 PKMYT1 CDCA5 CDK7 TTK MCM3 CDK2 MCM6 MCM2 PMC7884039__F12 Molecular mechanism of p75NTR in regulating age‐associated changes in the homeostatic of synaptic plasticity ROCK2 LIMK1 ARC ARHA BDNF PMC5974538__F1 Occurrence of plant photodynamic stress CPO FECH UROD UROS PMC4075272__F2 Signaling pathways altered by MVNP and mutant p62 NR1i1 TAF12 TRAF6 SIRT1 PMC3091694__F6 Toll-like Receptor signalling canonical pathway CSA2 TIRAP CD14 LBP PMC5578405__F10 Schematic summary of the possible link between IGF-1R signaling, synaptic changes, neurotransmitter function and inflammatory response HMGB1 HOMER1 IGF1 TLR4 ChAT IGF1R MTOR PMC8555850__F1 Bile acid regulation FGF8A CYP8B1 CYP7A1 FGFR4 GCA HSD3B7 CYP7B1 CYP27A1 PMC6973012__F1 Molecular mechanisms in allergic inflammation IL25 TSLP MBP IL33 ELL TNF PMC6701793__F2 Biological processes associated with up-regulated genes after cecal ligation and puncture and back-regulated by landiolol infusion STAT3 CD59 BDH1 SHC1 SLC35F6 FNDC3B PXK IPPK ST3GAL1 MAPK14 AHSG HMOX1 SPTLC2 MGST2 A2M CSNK1A1 TP53INP1 PDE10A DBH MAPKAPK2 FLOT1 IMPDH2 MARK1 CFDP1 ANP32B VAPA NUP93 EDNRB CENPA LCN2 MAX TRH CREM CAPN10 CDA NTF3 NOS1AP APP CERK PTPRN VASH1 ECSCR ENTPD1 FGF2 RPL10A NFKB1 NUDT4 HEL-S-102 NLE1 LBP ARHGAP10 PMC9234285__F3 Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation CXCR3 HLA-G CCR2 PMC11671501__F3 Apoptotic caspase-mediated pyroptosis BAX DFNA5 TNF PMC8027873__F2 STRING diagram representing protein interaction pathway derived from the 77 proteins quantified in at least 80% of OCT and in none FFPE samples TES NDUFB10 DLAT NPTN STK24 FHL2 DLD ZMPSTE24 FERMT2 PMC7142266__F1 Schematic elucidation of the FA pathway mechanism used during DNA repair ERCC1 ATR USP1 FAN1 PALB2 SLX4 PMC3111844__F1 Overview of Androgen Metabolism Pathway Genes Considered, Including Candidate Genes and Genetic Variants Studied SRD5A2 CGN PMC6912814__F1 Summary of the main mentioned markers of the autophagy-lysosomal pathway (ALP) LAMP2 PINK1 LRRK2 PARK2 PMC8281110__F6 M6A in osteoporosis, arthritis and osteosarcoma (Review) ATAD2 ALKBH5 YTHDF2 METTL3 DRG1 LEF1 CTNNB1 PMC4404310__F1 Proposed schema of aberrant signal transduction mediated by the TSLPR heterodimer in CRLF2-overexpressing ALL TSLP MTOR EIF4E PMC8281110__F3 M6A in osteoporosis, arthritis and osteosarcoma (Review) MGA CEBPA GDF11 MSC METTL3 TRAF6 MYD88 PMC5879898__F6 MAPK signaling pathway and the JAK-ATAT signaling pathway PIM1 EGFR EPO APP IL6 PMC9428757__F5 Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders? GSDMD NLRP3 TXNIP PMC8762245__F2 Exosomes Regulate NLRP3 Inflammasome in Diseases NLRP3 ABHD5 MSC PMC7250321__F9 EV71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS accumulation ACOX1 BACH1 MAF PMC6983994__F4 This study showed that after 24 hours of treatment with YM155, the miR-9 expression levels increased significantly compared to control cells; in addition, the expression of two target genes, including MDR1 and SIRT1, decreased significantly BCL2 ZEB2 SIRT1 PMC2788021__F3 A model for torpor induction in mammals that links reduced availability of food in the environment with the energy status of the cell, the mammalian circadian clock, and response to oxidative stress NAMPT SIRT1 PMC3982918__F1 Notch signaling pathway and agents in clinical development CCND3 DLL4 JAG2 MYC FURIN DLL3 PMC8891342__F1 Impact of intracellular innate immune receptors on immunometabolism ALDOB HK3 HK2 HEL-S-162eP HEL-S-87p CPT2 PMC5366816__F2 Drug targets in AR signaling pathway CYP17A1 EGFR MTOR PMC7078111__F1 HGF/c-Met signaling and lncRNA/miRNA/c-Met interaction HGF GRB2 MTOR PMC6881418__F3 Roles of CAFs in drug resistance CXCL12 SERP2 HGF PDGFC PMC8455403__F7 Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance HBEGF PGR IGFBP1 HOXA11 NRF1 SPP1 PMC9166529__F2 Characteristics of the cancer stem cell niche and therapeutic strategies SOX2 MTOR PMC8849249__F2 Low Bone Mineral Density in Hemophiliacs LRP5 LRP6 CTNNB1 PMC7705238__F1 IL-23/IL-17 signaling transduction TRAF4 STAT3 IL17RC TRAF3 IL23R TRAF2 PMC4888770__F1 Radiation induced activation of canonical and non-canonical hedgehog (Hh) signaling pathway HHIP SUFU SMO PMC9166529__F4 Characteristics of the cancer stem cell niche and therapeutic strategies SUFU DKK1 APC GSK3B SMO CTNNB1 PMC4503712__F3 Candida albicans proteins for metabolic pathway HEL60 HEL-S-32 MDH2 ADH5 PMC7705238__F2 T-cell immune axis and associated cytokines in the pathogenesis of psoriasis, hidradenitis suppurativa, atopic dermatitis, and alopecia areata S100A7 NLRP3 CCR6 S100A8 FLG S100A9 CCL20 PMC8208619__F6 CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K-Akt-mTOR pathway inhibition SI MTOR CXCR4 PMC9254464__F7 Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest RAB7A HEL-S-2a MTOR PMC3379883__F2 Leptin and the CNS Control of Glucose Metabolism STAT3 SOCS3 PMC8998760__F1 Interplay between PARP Inhibitors and Immunotherapy in Ovarian Cancer: The Rationale behind a New Combination Therapy CGAS GSK3B IRF3 PMC3045854__F1 Memory genes identified in model systems overlap with genes identified in human mental retardation EGF TSC2 TGFA TSC1 OPHN1 NF1 RHO GRB2 MTOR PMC7564838__F1 The metabolic pathway for MA biosynthesis in E SMO CS PMC9163322__F1 Novel Immune Checkpoints in Esophageal Cancer: From Biomarkers to Therapeutic Targets TIGIT LAG3 PMC7653260__F4 Signalling pathway of programmed necrosis in hearing loss TRADD MLKL TNF FADD PMC7653260__F3 Signalling pathway of autophagy in HL ATG12 ULK1 MTOR PMC8345080__F1 Osteopontin as a Regulator of Colorectal Cancer Progression and Its Clinical Applications NR1i1 BMPR2 SMAD1 DMP1 APC GSK3B SMAD4 TCF4 RUNX2 TGFBR1 CTNNB1 TGFBR2 ME3 DSPP PTCH1 BMP2 LEF1 PMC2702150__F3 FIBROTIC DISEASE AND THE TH1/TH2 PARADIGM TH NOS2 CD36 IL13RA1 PLG MMP9 PMC8479066__F6 Receptor tyrosine kinase ROR1 ameliorates AB1–42 induced cytoskeletal instability and is regulated by the miR146a-NEAT1 nexus in Alzheimer’s disease TH ROCK2 ARHA MAP2 PMC6940991__F3 Mutant p53 GOF and hypoxia ARHA MDM2 HDAC6 PMC6940991__F2 Mutant p53 gain of function (GOF) in metabolism and invasion STAT3 CCNG2 ARHA CCNB1 CCND1 PMC7753939__F5 Top significantly related pathways of “herb-ingredient-target” networks in JZD against NAFLD: (a) nuclear receptor transcription pathway; (b) regulation of lipid metabolic process PPARG NR1C1 NR2A1 IL3 F2 TLR4 NR1C2 TYMS TNF S100A13 FGFR2 PMC6906418__F1 Intracellular sensing of viral genomes and viral evasion TRIM13 TBK1 TRIM38 MAVS RIOK3 RNF123 LRRC25 TRAF3 FBXW7 MEX3C RNF125 USP15 USP4 UBE2D3 USP21 CYLD HDAC6 RNF122 ARL5B IRF3 IRF7 SSB USP14 TRIM25 USP3 DHX29 STAT4 TRIM4 TRIM65 ZCCHC3 PMC3820944__F6 Representative Tyr phosphorylation sites affected by erlotinib in the EGFR and ErbB2 canonical pathways CDC2 MAPK1 SHC1 PXN VAV2 PIK3R3 EGFR PIK3R2 PIK3R1 PTPN11 MAPK3 ERBB3 GRB7 PLCG1 SHC4 GSK3A ERBB2 INPPL1 GRB2 SRC PMC5899637__F1 Drug resistance in HER2-positive breast cancer brain metastases: blame the barrier or the brain? TSC1 PTEN PMC10635689__F8 BJ-5ta Exo exert a protective effect against UVB-induced photoaging RAD51 TGFB1 COX2 PMC7295987__F4 Outline of the signaling pathways activated by CpG PDPK1 TLR9 CD14 IRAK1 CD19 LYN IRAK4 MYD88 PMC6412245__F9 Schematic diagram shows the therapeutic effects of ergosterol on diabetic nephropathy PCNA SMAD2 SMAD4 PMC6906418__F2 Intracellular sensing of viral genomes and viral evasion TRIM14 RNF185 TRIM38 CGAS TRIM56 TRIM41 IRF3 IRF7 SENP7 TTLL6 TTLL4 HDAC3 OASL SENP2 ZCCHC3 PMC11771162__F3 Statins exhibit pro-angiogenic properties BMP2 RHO PMC6825561__F1 Proposed scenario of current strategies targeting different traits of dysfunctional mitochondria in Alzheimer disease (AD), including mitochondrial bioenergetics and mitochondrial homeostasis TFAM ULK1 APP MTOR NRF1 ULK2 SIRT1 PMC3538421__F3 Summary of P450 enzymes in cholesterol and bile acid biosynthesis CYP51A1 CYP8B1 CYP7A1 CYP46A1 CYP7B1 CYP3A4 CYP27A1 PMC11998530__F8 Abortive PDCoV infection triggers Wnt/Beta-catenin pathway activation, enhancing intestinal stem cell self-renewal and promoting chicken resistance APC GPR49 CTNNB1 PMC11432203__F7 Causality of CD4+ TEM markers and PTB and COVID-19 infection based on MR analysis (by Figdraw 2 GBP2 LAG3 PMC8116604__F4 Evolving landscape of N6-methyladenosine modification in the tumor microenvironment METTL1 PHLPP2 ALKBH5 GC METTL14 PC ATF4 METTL3 MYC PMC3397898__F6 Signaling pathways that regulate cAMP-mediated WPB exocytosis RALA PMC4863711__F2 An overview of different signaling pathways activated by high glucose ambience, which leads to an altered expression of various ECM glycoproteins, and of genes relevant to EMT and apoptosis processes TLR4 APC S100A8 GSK3B EEF2 MTOR CTNNB1 MYD88 PMC3538421__F5 Diagram showing the fundamental steps and P450 enzymes involved in vitamin D biosynthesis and degradation pathway NR1i1 CYP2R1 CYP27B1 CYP24A1 PMC3634798__F1 Stress response pathways HEL-S-22 GSTM1 CYP2E1 NQO1 PON1 AHR PAH CYP1A1 GSTT1 GPX1 PMC8728107__F2 Neural regulations of the tumor microenvironment CALCRL RAMP1 SRC PMC3717064__F1 NK cell activating and inhibitory receptors and their downstream signaling molecules ZAP70 SYK FYN LAT PC GRB2 LILRB1 LAIR1 LCK PMC8728107__F1 Neural regulations of the tumor microenvironment STAT3 GATA1 SRC PMC8891342__F3 Impact of intracellular innate immune receptors on immunometabolism IFNG NLRX1 FOXO1 NLRC3 AIM2 FOXP3 MTOR TRAF6 TNF PMC8027849__F1 Resistance to CDK4/6 inhibitors LATS1 STAT3 CDK6 HGF SPOP FGFR1 CDK2 FAT1 FBXO4 MTOR MYC CDK4 PMC9316979__F7 Transcriptome Analysis Reveals Key Gene Expression Changes in Blue Catfish Sperm in Response to Cryopreservation BAD CAD CASP2 OSM H2AX MLKL INA IRF9 AIP CS TNF RIPK3 LOX ZBP1 NLRP3 TLR3 IL18 CASP3 ATM USP21 CYLD FADD PMC8989532__F8 RNA polymerase pausing, stalling and bypass during transcription of damaged DNA: from molecular basis to functional consequences TEC RHO PMC2889604__F7 The regulation of neuronal migration and neurite outgrowth by the MRTF/Srf pathway CDK5 PAK1 RHO PMC4123481__F3 Role of STAT1 and STAT3 in Foxp3 expression and cytokine production in Tregs IFNG STAT3 STAT1 FOXP3 PMC5615630__F7 RSV inhibiting NKTCL cells STAT3 BAX BAD ATM PMC4498148__F1 WNT pathway is significantly upregulated in invasive mutant TP53 cells DIXDC1 EGR1 PCDH9 SCD SOX2 EVI1 CCNA2 KRT19 ID3 CTNNB1 BAMBI MME CCND2 DKK1 CCL7 MMP3 WNT1 PMC12018449__F1 AS-IV in the pathogenesis of arrhythmia BAX NLRP3 KEAP1 TLR4 MAF GPX1 PMC6795678__F1 Scheme of the parietal cell of a gastric gland CASR CCK HEL-S-11 PMC9131857__F9 Peste Des Petits Ruminants Virus N Protein Is a Critical Proinflammation Factor That Promotes MyD88 and NLRP3 Complex Assembly NLRP3 TRAF6 MYD88 PMC22753__F6 A signal transduction pathway leading to the phosphorylation and activation of mTOR in response to insulin PDK2 MTOR PMC7053123__F4 Gemcitabine resistance and metabolism STAT3 RRM2 FASN FBP1 MUC1 NAMPT MTOR USP9X HEL-S-26 LAT2 PMC6541752__F1 Comparison of nucleic acid signalling pathways leading to type I interferon (IFN) production in an autoimmune disease and bacterial infection TBK1 CGAS TLR4 NOD2 IRF3 TREX1 PMC5374984__F1 The autophagy pathway ULK1 AMBRA1 MTOR PMC3042782__F2 Models for HJV cleavage by furin-like activity and matriptase-2 BMP6 FURIN HFE2 PMC9312358__F4 Oxidative Stress in the Pathogenesis of Atherothrombotic Diseases SIRT3 VCAM1 HES1 SIRT1 NOTCH1 HEL-S-44 PMC6896241__F1 Representation of causal interaction data in a standardized format KIF7 SMO MYC PMC8998102__F3 Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism GSDMD NLRP3 IL18 BMP7 PMC3857153__F8 Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells PCSK9 CITED2 TNFAIP3 BRAF SOCS2 TNF TRAF2 BIRC3 PMC3157269__F3 Sensing the HP-PRRSV infection by host cell SOCS1 NMI SBNO2 STAT1 SARM1 TLR3 TLR8 IRF3 IRF7 TLR7 MYD88 PMC10181252__F1 Wnt/Beta-catenin signaling pathway in tumor progression APC GSK3B CTNNB1 PMC11172503__F2 Anti-senescence effect and molecular mechanisms of royal jelly (RJ) and its components on cellular senescence, healthy aging, and longevity induced by endogenous and exogenous factors ATR CDK6 CDK2 ATM CDK4 PMC4926373__F1 Schematic overview of DNA damaging agents, radiotherapy, DNA damage, the cellular response upon DNA damage, genetic variation, epigenetic regulation and cancer therapy response ATR RAD51 BRCA1 H2AX ATM PARP1 PMC6791057__F2 Mechanisms underlying the sex-specific establishment of the Wolffian duct ETV5 EGF EGFR FGFR1 ETV4 FGFR2 PMC11172503__F1 Nrf2 and NFKB signaling pathways by royal jelly (RJ) LOX COX2 NQO1 MAF MMP2 MMP9 TNF PMC10439834__F1 IL-17 signaling pathway: transduction and amplification TRAF4 EBP TRAF5 TRAF2 PMC10181252__F2 Various flavonoids on the Wnt/Beta-catenin pathway APC GSK3B CTNNB1 PMC4979424__F8 Proposed model of VacA effects on Cx43 and autophagy, followed by apoptosis ATG16L1 EEA1 RAC1 PMC9272004__F2 Heme Synthesis by Mitochondrial Homeostasis Proteins SLC25A38 HMBS CPOX ABCB6 CLPX FECH ABCB10 UROD UROS TMEM14C PMC7364656__F7 Sal and Das together synergistically inhibited the BRCA1 pathway in the MDA-MB-468 cell line BARD1 MSH6 STAT1 ATR ENG RAD50 ATRIP BACH1 MRE11A ATM ATF1 PLK1 PMC5938062__F6 TAK-733 under an Ang II-induced signaling pathway in vascular remodeling VCAM1 CCND1 PMC9456253__F4 Downstream Effects of Mutations in SOD1 and TARDBP Converge on Gene Expression Impairment in Patient-Derived Motor Neurons PPARG GATA2 STAT3 NKX3-2 AK6 TAF5 RPS8 RPL5 STAT1 PAX2 E2F6 TFAP2C NRF1 CREB1 ZNF354C TAF4 SREBF2 FOXF2 RPL13 NR2F1 RPL3 TAF12 RPS24 TAF11 IRF2 TP63 LSM7 TAF7 TAF6 EN1 FOXL1 TAF10 MAX USF2 YY1 RUNX2 POU2F2 FOXA1 RPS6 JUN RPL11 RPLP0 TFAP2A ARID3A NR3C1 RPL6 GATA3 TAF1 NR2A1 RPL10A NFKB1 RELA NFYA PMC6664006__F8 Proposed model to explain how COX-2 might be essential in the stimulatory pathway for ROS production and increased expression of profibrotic genes mediated by PRR activation SMAD2 NOX4 PMC529535__F1 Two models relating Akt and Tsc2 in cell growth control in Drosophila RHEB TSC2 TSC1 PTEN PMC4333106__F2 Canonical and alternative androgen biosynthesis pathways CYP17A1 CYP11A1 SULT2A1 STS PMC5753567__F1 Relation between activated WNT/Beta-catenin pathway and Warburg effect in ASD HEL-S-133P APC LRP5 LRP6 PMC8377336__F3 On the nutritional and therapeutic effects of ketone body d-Beta-hydroxybutyrate FFAR3 NLRP3 PDC PMC4429755__F1 Regulation of miRNA biogenesis as an integrated component of growth factor signaling GAA DGCR8 DROSHA PMC4429755__F3 Regulation of miRNA biogenesis as an integrated component of growth factor signaling DGCR8 DROSHA PMC8552790__F9 Schematic diagram of GTF2F2 related functions MAX CDC2 BAX BCL2 MYC CDK9 PMC8585009__F5 Diagram depicting the 2 branches of the fat remodeling program controlled by neuronal activation of Hsf-1 TF ERAF PMC8170687__F1 Integrin function is regulated by conformational activation and vesicular traffic and is crucially involved in mechanosensing and TKR signaling CD44 GGA2 RAB13 PMC9505042__F7 TGFB/SMAD Signaling Pathway Prevents Follicular Atresia by Upregulating MORC2 TGFBR2 BAX SMAD2 MORC2 SMAD4 BCL2 TGFBR1 PMC7893589__F3 Effects of miR-320 on glucose and lipid metabolism in cardiomyocytes AGO2 IGF1 CD36 PMC9348444__F4 Comprehensive role of SARS‐CoV‐2 spike glycoprotein in regulating host signaling pathway TMPRSS2 TLR1 NRP1 ACE2 PMC7571393__F2 Summary of the regulatory network and mechanisms of circ_ASPH in CCA cells.Abbreviations: ASPH: aspartate B‐hydroxylase; CCA: cholangiocarcinoma ABCG1 ASPH PMC3045450__F4 NAViGaTing the Micronome – Using Multiple MicroRNA Prediction Databases to Identify Signalling Pathway-Associated MicroRNAs RHEB PIK3CA TSC2 TSC1 EIF4EBP1 HEL-S-67p FOXO1 RPS6KB1 PIK3R2 PTEN EIF4E PMC5242433__F6 Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial DBF4 CDK7 PCNA CDC45 ORC6 SMAD4 CDK2 MDM2 MYT1 SKP2 PMC10886007__F3 TGFB/SMAD signaling pathway SMAD1 DKFZp781O1323 GDF11 SMAD2 BMP4 BMP2 SMAD6 SMAD4 BMP7 PMC10886007__F2 Mitochondria-dependent apoptosis pathway HTRA2 BAX BCL2 PMC9604720__F1 Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review PLG MMP2 MMP9 BDNF FURIN PMC3552884__F8 Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells EEF2K DDIT4 ATF4 MTOR PMC10886007__F5 PI3K/Akt/mTOR signaling pathway RHEB BAX TSC2 TSC1 FOXO1 PTEN PMC5661609__F1 Dysregulation of KRAS signaling pathway in PDAC tumors compared with that in the paired adjacent non-malignant tissues GNAI3 GNAI1 PIK3CA RAF1 SHC1 SOS1 BRAF PTEN MTOR ARHA KRAS ARAF RALA RASA2 PAK1 PRKCA MAP2K1 MAP2K2 GRB2 SRC RALBP1 PMC10886007__F4 AMPK/SIRT1/PGC-1A signaling pathway TFAM KEAP1 NRF1 SIRT1 PMC4895609__F1 Simplified schematic illustration of PI3K/Akt and mitogen‐activated protein kinase (MAPK) signaling pathways in thyroid cancer BRAF PTEN MTOR PMC9418004__F8 Mechanistic illustration showed PLAA-METTL3-TRPC3 axis in ovarian cancer METTL3 TRPC3 PLAA PMC6855007__F10 Illustration representing the mechanisms of compound 1-induced human breast cancer cell apoptosis ATR BAD EGFR ATM PMC9163393__F3 Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression STAT3 EGF EGFR UCK2 MMP2 PMC5973841__F2 Filoviruses inhibit the type I IFN response at multiple steps STAT1 MAVS STAT2 IFNAR2 IRF9 IFNAR1 TANK TRAF3 JAK1 TYK2 MYD88 PMC7854502__F5 Developmental pathways in liver cancer NR1C1 PIG59 SOX9 IHH IGF2 RBPJ SPP1 CTNNB1 PMC7826004__F3 Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms TMPRSS2 SI ACE2 PMC9657162__F8 Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood–Milk Barrier ATG16L1 NLRP3 ATG12 ATG5 PMC5655367__F4 Modulations of adaptable responsive genes in acclimation PRLR EGF BAD LEP OXTR SCTR TACR2 MAFA NRG3 MC2R GCGR MTOR INS GHRHR MYC FSHR LTB4R LPA CDA INSR BTC SRC GHR JUN LEPR TRPV1 SHE TRHR IRS1 MLNR NRG2 CRK NRG1 HBEGF CBL GHSR GRB2 PMC2939362__F1 Domain organization of proteins in the Hh signaling pathway EGF HHIP BOC SMO GAS1 PMC7793976__F1 Action of emapalumab STAT1 JAK1 PMC7852140__F3 Metabolic pathway of norvancomycin biosynthesis up-regulated in high-yield strain MAL CIT PMC6059757__F15 PPI networks for key KEGG pathways ADCYAP1R1 SMAD9 CXCL12 CADM1 LEP PIK3R5 AVPR2 COL4A3 WNT3A CHRM1 RXRG CDKN2B WNT2B CD99L2 FGFR2 CSF3R NTNG1 CHRNA2 HLA-E ADCY9 CLDN18 FGFR4 TBX3 NR1A2 GHR P2RX6 SIGLEC1 BMPR2 RASGRP4 RUNX1T1 F2RL3 JAM3 CD34 ID3 SPN NMUR1 DAPK2 PTGER4 PMC5074086__F1 Pheochromocytoma: The First Metabolic Endocrine Cancer ACLY FH CS MDH2 PMC11627363__F7 Golgi apparatus stress response pathway activated by AIV infection ST3GAL6 ATP6V1A MGAT2 PMC3289121__F5 IPA illustrating the predicted effect of milk removal on PI3K signaling in T lymphocytes BLK DAP PTEN PMC6021929__F5 Pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants PRSS53 F5 ABO EPO FGA SLC44A2 PMC7870789__F1 Tumorigenic mechanisms in somatotroph cells GPR101 AIP GHRHR GIPR PMC5370075__F4A Biomechanical relationships between the corneal endothelium and Descemet’s membrane LATS1 LPA LATS2 RHO PMC9951170__F2 When AHR signaling pathways meet viral infections AHR AHRR SRC PMC8899182__F2 Regulation of PBXs and their emerging role in cancer STAT3 PBX3 PBX1 NOTCH3 USP9X PMC3192251__F2 NPC and CF converge on multiple intracellular trafficking pathways NPC2 NPC1 CFTR PMC9576519__F9 Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways HDAC3 HDAC1 NTF3 PMC6274888__F1 Response to immunotherapy in pancreatic ductal adenocarcinoma (PDAC) relies on destroying cancer cells as well as on breaking the stromal barrier and flaring up immune function SHH ARG1 CXCR4 PMC9598694__F9 Thiamine Supplementation Alleviates Lipopolysaccharide-Triggered Adaptive Inflammatory Response and Modulates Energy State via Suppression of NFKB/p38 MAPK/AMPK Signaling in Rumen Epithelial Cells of Goats BAX IL10 TLR4 SIRT1 PMC5838032__F5 Overview of the metabolism of sugars, amino acids, and related compounds GAL AMT PMC6157734__F2 Human CARD9 signaling pathway HRAS SYK CSF2 BCL10 CXCL1 CXCL2 IL6 IL1B CARD9 PMC7648118__F2 Therapeutic strategies targeting the NMJ in dystrophic muscle MUSK RAPSN LRP4 GABPA PMC3634610__F2 Signaling network of Dectin-1 SYK NLRP3 BCL10 PLCG2 RELB CARD9 PMC6711424__F1 CNVs, SNVs/indels on histamine‐related metabolism and signalling pathways MAPK11 HDC MAPK13 SLC22A2 MAPK12 VAMP8 BIK YWHAZ PMC6021929__F2 Pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants RGS2 PDE3A DLG4 RASGRF2 SRR TNIK SBSN VCAN EMCN PMC3634610__F3 ITAM-like-bearing CTLRs within the Dectin-1 cluster SYK CLEC9A PLCG2 TNF PMC5943343__F7 Proposed Model: The figure shows that mutation in GNE inhibits sialic acid synthesis that may cause hyposialylation of IGF-1R BAD GNE IGF1 BCL2 PMC8071448__F2 Examples of functions of human disease-related retrocopies HMGA1 INSR PTEN CP PMC9226217__F2 Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells TLR1 MAL CD14 MYD88 PMC8351721__F7 Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer CDC42 LIMK1 APC RHO AVP PMC9603894__F1 Oncolyic Virotherapy for Prostate Cancer: Lighting a Fire in Winter IRF3 IRF7 TRAF3 PMC8790913__F8 SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration TF HLA-DMB HLA-DPB1 HLA-DPA1 TNF HAVCR2 TREM2 HLA-DMA HLA-DRA TYROBP FCER1G CX3CL1 CCL4 CSF1R PMC8750882__F12 Extracellular Vesicles Derived from Bone Marrow in an Early Stage of Ionizing Radiation Damage Are Able to Induce Bystander Responses in the Bone Marrow WNT10B BAMBI FZD5 CTBP2 LRP5 NLK CTNNB1 PMC11266911__F2 Molecular mechanism of antitumoral properties of 6‐shogaol CDH2 CCND3 STAT3 BAX CSA2 PCNA MTOR CCNB1 CCND1 HES1 NOTCH1 PMC6510997__F1 Immune signaling network in MS IFNG JUN TIRAP INSR RELA HEL-S-102 NTRK2 SRC INS FOS PMC6414715__F10 Activation of antiviral pathways in Atlantic cod TAB3 TANK TLR9 IRF3 IRF7 TRAF3 TRAF6 IRAK4 PELI1 MYD88 IFNG IFNGR2 TLR3 NFKB1 NFKBIA TLR7 FADD PMC5010470__F1 NF-kB signaling pathways CSA2 TNFAIP3 RELA RELB HELB PMC9014844__F3 Using Intermittent Fasting as a Non-pharmacological Strategy to Alleviate Obesity-Induced Hypothalamic Molecular Pathway Disruption IFNG NPY AgRP PMC9306208__F4 Senescence in osteoarthritis: from mechanism to potential treatment ATR HLA-E DPP4 ATM MICA IL6R PMC8780935__F3 Research progress on the hedgehog signalling pathway in regulating bone formation and homeostasis HHIP GSK3B IHH BMP7 GH1 RUNX2 CTNNB1 SUFU BMP4 BMP2 SHH WNT1 SMO ATF4 PMC6092675__F8 Inhibition of mTOR activity with rapamycin SMAD2 SMAD4 MTOR TGFBR1 PMC3365794__F2 Model showing arterial, venous, and lymphatic cell fate specification in the developing embryos EPHB4 PROX1 NRP2 SOX18 PMC7333391__F5 Postulated mechanism by which CagA promotes the expression of IL-6 in gastric cancer STAT3 OSM OSMR EEF1A1 PMC4827621__F9 Deletion of KvB1.1 subunit leads to electrical and haemodynamic changes causing cardiac hypertrophy in female murine hearts KCND2 MYH6 KCNAB1 GATA4 IL1B PMC3311240__F11 Muscle cell signaling in response to 1E3 CDC42 SOST PAK1 GRB2 RAC1 PMC3978640__F6 Blocking the transforming growth factor B (TGFB) signalling pathway SMAD2 SMAD4 TGFBR1 PMC3324906__F1 Pivotal role of E-cadherin, Beta-catenin, and transforming growth factor B (TGFB) and Wnt signaling pathways in an epithelial-mesenchymal transition (EMT) program SMAD2 APC GSK3B SMAD4 PMC8693183__F5 Gill Transcriptomic Responses to Toxin-producing Alga Prymnesium parvum in Rainbow Trout CRP STAT3 MAP3K7IP1 MAPKAPK2 A2M TRAF2 LBP PMC9013079__F8 L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKBeta-AMPK signaling pathway TG NR1C1 FASN MTOR CPT1A PMC8267469__F7 Systems Pharmacology–Based Dissection of Anti-Cancer Mechanism of Traditional Chinese Herb Saussurea involucrata STAT3 RPS6 EGF CASP9 BAD LTA MTOR IL6 TRAF3 TNF IL6R COX2 RXRA MDM2 SRC TRAF2 PMC5075921__F4 Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data TGFA MAP3K1 IGF1 MAP3K7 IL1A PMC6882011__F4 Pathway display visualisation of significant changes in primary/intermediary metabolite abundances observed between COL2246 and ECU72 during the infestation cycle IDE IPP UNK PMC8317513__F5 FHL1 Inhibits the Progression of Colorectal Cancer by Regulating the Wnt/Beta-Catenin Signaling Pathway MMP7 APC GSK3B AXIN1 LRP5 LRP6 FHL1 TCF4 CCND1 LEF1 CDK4 CTNNB1 PMC5260790__F3 Differential methylation network of schizophrenia TMEM30A FUS DLGAP2 RNF123 MPHOSPH6 CD320 NDUFA10 EDRF1 HOXA1 ZNF322 GTF3A LRRC41 RBM14-RBM4 ZNF830 CLCN2 RCOR3 SUGP1 SHH SMO BMF AGL TBP FPGS P2RX6 DIS3L2 MYH10 GNB2 MNT TLE4 ZC3H10 TUBB HEL-S-94n IRF2BPL POLR2H RNF213 CAPNS1 IRF2 MAP3K7 ADAM10 ELK3 MIOS GNA13 NPPC KLHL20 ARHG GPR37 HOXC13 MED4 NDUFA6 PAOX BLM AKAP10 PRKCB FOSL2 SUCLG1 INPP4B RPL27 GABPB2 BATF3 ANKRD11 EEFSEC CPNE3 CDC73 PRDM14 HEL-S-67p EIF4EBP1 FASN HOXA11 BACE2 HHIPL2 PTPRN2 PROX2 GIT2 TMOD3 DCAF10 MGME1 RAMP1 DDX47 ASNS CAMK2G AATF PMC9409657__F6 Angiotensin II Receptor Blocker Irbesartan Enhanced SIRT1 longevity Signaling Replaces the Mitochondrial Biogenetic Survival Pathway to Attenuate Hypertension-Induced Heart Apoptosis BAX FAS SIRT1 FADD PMC2757955__F10 Proposed model of IGFBP-3 modulation of growth factor receptor activation mediated by S1P EGF EGFR SPHK1 SKI PMC2100073__F6 Filamentation signaling pathway recovered completely CDC42 FAR1 PMC86880__F1 Receptor proximal signaling pathway for IL-1 TRAF6 MYD88 PMC6585752__F2 Characterization of network connectivity between highly expressed interferon (IFN) response genes SIGLEC1 IFI6 IFIT1 IFIT3 IFIH1 IFIT2 CMPK2 RSAD2 OAS3 XAF1 IFIT5 PARP12 USP18 OASL ZCCHC2 EPSTI1 HERC6 MX1 OAS1 OAS2 EIF2AK2 PMC8047301__F3 Leucine sensing signaling pathway upstream of mTORC1 and the potential role of exercise RHEB TSC2 FLCN PMC2949481__F2 Insulin, IGF-I and IGF-II signaling through the IGF-IR RHEB TSC2 BAD TSC1 PTEN MDM2 GRB2 MTOR IRS1 PMC7035994__F2 Polarity proteins in oncogenesis LLGL2 DLG5 SCRIB PMC3073074__F1 The pathway of propionyl-CoA to succinyl-CoA metabolism is displayed MMAA PCCA PCCB MCEE PMC4163915__F11 Model is presented whereby serine phosphorylation of IRS-1 serves as a mediator of Ang II to inhibit insulin-induced Akt Thr308 phosphorylation HBEGF EGFR MTOR INS PMC7035994__F1 Apico-basal polarity proteins play a critical role in homeostatic control of cell density LLGL2 DLG5 PATJ LLGL1 MARK4 PALS1 MARK1 SET PMC4564397__F1 HOCl signaling pathway A LPO PMC1526464__F8 Bile acid and cytokine inhibition of CYP7A1 gene transcription NR2A1 CYP7A1 IL1B PMC6230871__F7 Differentially expressed miRNA-mRNA pairs in nuclear factor of activated T cells (NFAT) cardiac hypertrophy pathway from NHE1 transgenic mouse hearts GAL CTF1 CRAT IGF1 LIF GSK3B NACA2 IGF1R GRB2 DAO PMC4564397__F2 The NO/peroxynitrite signaling pathway A POR LPO PMC4564397__F4 Salicylic acid and anthocyanidins use different strategies to inhibit tumor cell protective catalase NONO H1-5 CPD PMC6230871__F3 Genes altered in NHE1 transgenic hearts were enriched in KEGG hypertrophic cardiomyopathy (HCM) pathway SGCB MYL3 SGCD MYH6 MYL2 SGCG DMD TNF SGCA PMC6360084__F8 Identification, expression, and phylogenetic analyses of terpenoid biosynthesis-related genes in secondary xylem of loblolly pine (Pinus taeda L.) based on transcriptome analyses IPP PMVK MVD MVK PMC3793031__F2 Symbiotic signaling downstream of oscillations MYC ERN1 PMC8847772__F1 Search for Biomarkers and Treatments in Chagas Disease: Insights From TGF-Beta Studies and Immunogenetics SMAD2 SMAD4 PMC6340093__F1 Interacting enzyme in the monolignol biosynthetic pathway RP1 CAD ACD RAC1 PMC7022462__F2 Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression APC MTOR CTNNB1 PMC10532123__F6 Myogenetic Oligodeoxynucleotide Induces Myocardial Differentiation of Murine Pluripotent Stem Cells MESP1 MESP2 MYH6 SOX2 TBX5 FZD4 ISL1 DKK1 PDGFRA POU5F1 CER1 KDR NKX2-5 GATA4 NCL PMC3809361__F1 Metabolism of cancer cells is regulated by signaling pathways related to oncogenes and tumor-suppressor genes PTEN TIGAR SCO2 MTOR MYC PMC3979678__F3 Global Changes in Gene Expression of Barrett's Esophagus Compared to Normal Squamous Esophagus and Gastric Cardia Tissues ZFP36 CAST TGFB1 TGFA TJP1 HEL-S-53e CD36 MCL1 PMAIP1 DST SST TMOD3 NR2F2 CCNG2 IL1RN CD9 SPRR1A IL13RA1 IL18 SERPINB2 MUC4 CA9 PMC7693871__F7 The pathway of Ac2-26 effect: (A) the mechanism of the anti-inflammatory responses of Ac2-26 in HaCaT cells STAT3 PMC6978911__F8 Schematic comparison between CiTLR22a- and CiTLR22b-mediated signaling pathways IRAK3 IRF3 IRF7 MYD88 PMC11534861__F2 Histone lactylation in cancer GPR37 HEL-S-133P PER1 BZW2 PMC8431490__F3 The BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin LTBP1 STAT3 BAX VCAM1 VEGFA CTNNB1 PMC6249275__F3 Keap1-dependent and Keap1-independent mediated Nrf2 signaling RBX1 KEAP1 GSK3B MAF AHR PMC6249275__F1 Natural products activating Nrf2 signaling pathway ABCG1 RBX1 KEAP1 CD36 ABCA1 PMC8087812__F2 Response of green leaf volatile (GLV) biosynthesis in MeJA-primed fresh tea leaves ALDH2 LOX PMC4592906__F2 TNF-induced programmed cell death pathways TRADD MLKL TNF CYLD FADD PMC8247436__F4 Diverse Roles of TgMIC1/4/6 in the Toxoplasma Infection CD40 MICA MYD88 PMC8056770__F1 Pleiotropic roles of leptin in metabolism, immunity, and cancer STAT3 LEPR SOCS3 FOXP3 MTOR PMC8841363__F2 Network based systems biology approach to identify diseasome and comorbidity associations of Systemic Sclerosis with cancers PYROXD2 AZIN2 RNPC3 CXCL1 SMOX PAOX C1QB COL10A1 ADI1 VSIG4 CXCL3 MMP11 AMD1 ALDH2 SRM CD93 MSR1 THBD CPSF1 CD163 TRIO PKIB JDP2 MTAP SMS PKIG COL9A1 CD14 CXCL2 G0S2 IL6 SAT2 AGMAT MRC1 C1QA COL16A1 C1QC EDNRB PKIA COL12A1 APIP COL5A2 NAV3 PMC4329480__F1 Molecular mechanisms regulating mitophagy USP30 PINK1 CLEC16A HEL-S-62p BNIP3 PMC11534861__F4 Relevant mechanisms of lactylation in the development of cancer by modulating TME HIF1A METTL3 FOXP3 VEGFA PMC2981143__F1 Folate metabolism and its contributions to physiological processes DHFR PEMT PMC4423527__F1 Neddylation pathways influencing NFKB and HIF-1A IFNG PMC5319840__F3 Tgfbr2 cKO CD34+ SCC cells upregulate genes implicated in invasive human cancers C6 RASSF2 HEL113 SLA RECK TNS1 CCL2 CORT TPR HLA-DRA NID2 WAS EVI2A C4B_2 LRRC7 DCN SRGN GAL LCP2 CFD COL14A1 MMP9 SPP1 FTH1 OGFR FGL2 EDNRB APOB CP PMC2640984__F3 Distribution between short and long flap removal pathways PIF1 DNA2 FEN1 PMC3181439__F1 Jun N-terminal kinase signaling pathway STAT3 BAX DUSP19 HSF1 KNS2 APP ATF2 GCK TRAF2 PMC6831194__F5 Discovery of metabolic pathway identified in both optimal cutting temperature-embedded and formalin-fixed paraffin-embedded samples APRT GLS EPO DHODH GDA PARS2 APOBEC4 CDA UCK1 GUK1 UCK2 PC UMPS NT5M AID PKLR ARG2 CAD GPT2 ME3 DLAT ADK DLD XDH ASNS GLS2 ADA PMC4834538__F7 Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis WNT3A NFATC1 PMC10758155__F6 Huaier suppresses cell viability, migration and invasion in human non-small cell lung cancer via lncRNA DLEU2/miR-212-5p/ELF3 axis NOTCH3 ELF3 PMC11988921__F1 Unfolded protein response (UPR) signaling pathway consists of three major branches: activating transcription factor 6 (ATF6), inositol-requiring enzyme-1A (IRE1A), and PKR-like ER kinase (PERK) ATF4 XBP1 TRAF2 PMC9199543__F3 Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future Perspective HDAC1 COX1 PTGS1 SIRT2 MTOR BDNF HDAC2 PMC5905465__F1 Structure of NFKB members.Notes: The NFKB family consists of three proteins with a transactivation domain (RelA [p65], cRel, and RelB) and two proteins lacking a transactivation domain (p105/p50 and p100/p52) CD40 LTBR RELB PMC4084552__F1 IL-33/ST2 signaling pathway IL33 SIGIRR TRAF6 IRAK4 MYD88 PMC2932466__F3 Signal transduction mechanisms involved in the mediation of cellular responses induced by secreted MIC-1 cytokine in certain cancer cells EGFR SMAD4 ARHA PMC7066027__F5 Roles of miR-30c family members in drug resistance EGFR TWF1 YWHAZ PMC7066027__F4 Roles of miR-30c family members in carcinogenesis, metastasis and invasion HEL113 TWF1 KRAS PMC1380241__F1 CoQ10biosynthetic pathway with eight known biosynthetic enzymes denoted as COQ1–COQ8 COQ7 COQ3 COQ2 COQ6 COQ5 PMC4928589__F2 Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective RICTOR ULK1 FOXO3A MTOR DEPTOR PMC11049089__F1 Signaling cascades of TLR4 and TLR2 receptors SOCS1 JUN LTA IRAK1 IRF3 TNF TRAF6 IRAK4 FOS RAC1 MYD88 LY96 RIPK2 NOD2 NOD1 PMC5520418__F2 PTEN functions in T-cell development, activation and differentiation APC PTEN PMC8999457__F2 Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous System TBK1 RNF125 MAVS TLR3 IRF9 IRF1 IRF3 IRF7 PMC1383660__F6 Intracellular signalling pathways activated by leptin STAT3 CEBPA PDE3B NPY ARHA PMC8290198__F1 Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events PLCG1 HEL-S-81p CD69 ITK GRB2 LCK PMC1383660__F5 Intracellular signalling pathways activated by leptin EGR1 PI3 GRB2 PMC2494808__F3 Graphical representation of connections between receptors and pathways implicated in NTS baroreflex modulation by pharmacological studies CDC42 TSC2 BAD ADM FRK MDM2 GRB2 PMC1829419__F4 Hypothetical regulatory network influencing honeybee pollen foraging behavior modulated by insulin-like signaling and its effects on ovarian development PTEN PIN4 PIN1 PMC4682888__F2 Integration of Akt and mTORC1 signaling into the IL-4R and TLR4 pathways TLR4 JAK3 JAK1 PMC4518158__F1 Unfolded protein response ATF4 EIF2A XBP1 PMC7277983__F2 TNF-TNFR2 signalling pathway in the immunosuppressive cells RIPK1 TNF TRAF2 PMC7400846__F2 Cholesterol and bile acid biosynthesis ABCG8 ABCG5 SP1 ABCB11 ACAT2 LDLR SP2 SHE INSIG1 PMC7564116__F3 Functions of circRNAs in colorectal cancer (CRC) CDK6 PMC7007672__F3 Molecular pathways in embryogenesis of the liver PROX1 CEBPA NR2A1 HHEX SMAD4 TBX3 GATA4 ONECUT2 PMC8859251__F9 Biomarker Value of miR-221 and miR-222 as Potential Substrates in the Differential Diagnosis of Papillary Thyroid Cancer Based on Data Synthesis and Bioinformatics Approach TSC2 BAD PFKP C2 SI SRC GATA4 DAO PMC9686346__F3 Health benefits of Nigella sativa on diabetes mellitus and its complications: A review from laboratory studies to clinical trials BAX TG IGF1 LPO PMC2885511__F2 Diagram of PDGF-D cross-talks with other pathways PDGFD PLG MTOR PMC8068079__F2 Base excision repair, nucleotide excision repair and mismatch repair pathway PCNA POLG POLE PARP1 XPC PMC8615493__F6A Mechanical Stretching-Induced Traumatic Brain Injury Is Mediated by the Formation of GSK-3Beta-Tau Complex to Impair Insulin Signaling Transduction GRB2 BDNF IRS1 PMC2782433__F1 COPPER ACTIVATION OF NFKB SIGNALING IN HEPG2 CELLS DUSP5 HEL-S-101 THBS1 VLDLR MXD1 RELB MARCKS SQSTM1 ANGPT2 HEL114 MAP3K8 GRB10 PLK3 NFKB1 TTN P2RY6 KLF5 CCL20 NPPB HIVEP2 POP7 PMC8502815__F7 Beta-Carotene in Colonic Inflammation and Intestinal Barrier Integrity CRP TLR4 CD14 TNF IL1B PMC8636732__F2 Understanding the Complex Milieu of Epithelial-Mesenchymal Transition in Cancer Metastasis: New Insight Into the Roles of Transcription Factors CDH2 HGF PAK1 EGFR SMAD2 APC PEMT GSK3B SMAD4 HIF1A ZEB2 CTNNB1 PMC4509066__F2 Signaling pathway of cell apoptosis under cordycepin stress BAX TRADD APAF1 FADD PMC6874977__F3 PPI network analysis PMCH GNGT1 CXCL12 F2RL2 OXTR NPY1R CHRM1 CXCL1 CXCL8 CXCL3 PPBP SSTR2 APLN CNR1 NPY INSL5 CCR8 UTS2B SAA1 EDN3 GAL GNG4 AGTR1 CXCL2 CXCL6 GPR4 PPY SST HCAR3 GCG GALR1 CCL28 CXCR1 PROK2 FPR1 FPR2 PMC9408960__F1 Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases LTB TNFRSF9 RELB TFG EDARADD TRAF6 EDAR TNLG7C PMC10179184__F2 Mechanism of CYLD function in oxidative stress-induced DNA damage OTULIN CYLD PMC11332896__F2 Signaling pathways involved in muscle atrophy during cachexia IGF1 SMAD2 IGF1R IL6 MTOR PMC10236263__F6 Models of the positive regulatory feedback loop of p65/miR-27a-3p/TAB3/NFKB axis TAB3 TRAF3 MAP3K14 PMC4357015__F1 Structure, Function and Inhibition of the Phosphoethanolamine Methyltransferases of the Human Malaria Parasites Plasmodium vivax and Plasmodium knowlesi PSD PC PMC8394995__F2 BRCAness as a Biomarker of Susceptibility to PARP Inhibitors in Glioblastoma Multiforme KDM4A ATR RAD51 EGFR ATM PTEN KDM4B MTOR MYC VILL PMC7857921__F4 Selected pathways up- and downregulated by the additional hemorrhagic shock C5AR1 ADAM9 TIRAP CCL3 TLR4 S100A8 CD14 S100A9 PMC9537693__F8 4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid inhibits angiogenesis via modulation of vascular endothelial growth factor receptor 2 signaling pathway STAT3 ARHA VEGFA CCND1 PMC11909752__F8 The proposed mechanism for chronic adrenergic stimulation induced heart failure via cAMP-PKA-PDE4D signaling pathway and protective mechanism of PDE4D inhibition PINK1 PDE4D SIRT1 PMC4876997__F6 Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15 NR1i1 EGR1 PTCH1 SHH IHH PRKAR1A RUNX2 CREB1 PMC524028__F2 Regulation of the mTOR signaling pathway RHEB RPS6 TSC2 TSC1 EIF4E PMC12055817__F2 Possible mechanisms underlying crosstalk between microglia and astroglia NOS2 VEGFB TGFA NLRP3 CX3CL1 AHR CXCL10 CCL2 PMC11772370__F3 Protein lactonylation modification is an important influence in the process that is HIF-1-mediated HMGB1 activity HMGB1 HEL-S-68p TLR4 PTEN MTOR MYD88 PMC12055817__F3 Antidepressant mechanism of natural anti-inflammatory products NLRP3 TLR4 BDNF PMC3755464__F3 Recombination-independent interstrand crosslink repair pathway in vertebrates REV1 XPC PMC5354803__F3 Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis NR1C1 COX2 DHCR24 MDM2 CCND1 CTNNB1 PMC11772370__F1 Metabolic crosstalk between neurons and glia involving lactate is implicated in epilepsy SLC25A5 HMGB1 NLRP3 PMC5354803__F5 Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis OGG1 STAT3 NR1C1 RAF1 SNAI1 COX2 PTEN SOCS3 IL1B RUNX3 PMC6753173__F5 Schematic diagram of the pathogen-derived molecules used to escape cytokine-sensing pathways in cells STAT1 STAT2 IFNAR2 IRF9 IFNAR1 IFIT3 EIF2A JAK1 TYK2 PMC6753173__F4 A schematic diagram of pathogen-derived molecules used to escape intracellular DNA sensing pathways TBK1 CGAS DDX41 AIM2 IFI16 IRF3 PMC2777122__F2 Step 2: T-cell activation and costimulation HEL-S-92n APC PMC6397695__F2 IDO1-Kynurenine-AhR signaling in TME immunosuppression IFNG IDO1 AHR PMC4215179__F1 Protein trafficking of pericellular proteases MMP2 MMP9 PMC6514093__F3 Predicted arsenic resistance pathway in R HEL-S-62p MTR PMC7956936__F8 Mechanistic view of anthracycline-induced cardiotoxicity C7 HEL-S-62p APAF1 FADD PMC9242064__F2 Inflammatory bowel disease and cardiovascular diseases: a concise review TFPI F5 F2 PMC4303261__F6 Computational Approach to Identifying Gene-microRNA Modules in Cancer THBS1 COMP TIMP3 COL1A2 MMP19 RECK PLAUR THBS2 CTSK FAP EPYC MMP11 VCAN MYLK ACTA2 INHBA ITGB1 COL16A1 PDLIM3 CALB2 AQP1 PMC4303261__F5 Computational Approach to Identifying Gene-microRNA Modules in Cancer AEBP1 MMP19 THBS2 CTSK FAP COL3A1 MMP11 VCAN LOXL2 COL6A1 INHBA TDO2 DPT GREM1 MMP2 ADAM12 COL5A3 PMC9688668__F2 Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and Immunotherapy RHEB TSC2 PI3 PTEN GRB2 TNF DEPTOR IRS1 PMC7766850__F8 Scheme of the effects of AMPAR antagonists on spontaneous seizure activity in epilepsy rats based on a previous and the present studies CDK5 PTEN SRC PMC3837137__F6 A diverse range of signaling pathways that can lead to persistent PKC activation to support cell migration ARAF LPA EGF RFFL BRAF MYC PMC8507231__F1 Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases ADK ADA PMC5359747__F1 Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction ARF6 ARHA SRC RAC1 ROBO4 MYD88 PMC3843239__F7 Mechanism of myosin II–mediated release of microparticles from endothelial cells activated by antiB2GPI antibodies IRAK1 RHO TRAF6 IRAK4 MYD88 PMC8307395__F3 Two-Pore Channels Regulate Expression of Various Receptors and Their Pathway-Related Proteins in Multiple Ways CDC42 HRAS NFIB MAK ROCK1 CR2 DAP3 PMC8708574__F4 CXCL13 in Cancer and Other Diseases: Biological Functions, Clinical Significance, and Therapeutic Opportunities CDH2 BAD CXCL13 GSK3A CXCR5 SRC DOCK2 PMC3148231__F12 MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus CBL PTEN IRS1 PMC3224437__F4 Fatty acid biosynthesis model and pathway distance calculation method FAS SCD PC FADS2 FADS1 PMC3355926__F1 Activation of the Pi3K/Tor pathway by insulin and glutamate TSC2 TSC1 NF1 PTEN FMR1 PMC1899924__F8 Signaling pathways activated by mitogenic concentrations of TNFA and roles of furin, MT1-MMP, and MMP2 in the activation of the nSMase in mesenchymal cells MMP2 FURIN TNF PMC4837277__F1 Involvement of ROS in regulating M1 responsible phagocytic activity and inflammatory response ECSIT IL18 TRAF6 PMC6329517__F6 Impaired autophagic and mitochondrial functions are partially restored by ERT in Gaucher and Fabry diseases TFAM TFEB MTOR PMC4993159__F2 Hepcidin Regulation in the Anemia of Inflammation STAT3 HAMP IL6 HFE2 PMC6769473__F3 Genetic network and functions of PSGs (positively selected genes) related with the KEGG pathway of the PPAR signaling pathway, fat digestion and absorption, vitamin digestion and absorption PLB1 APOC3 GOT2 ACSL3 SCD LRAT MOGAT2 PCK1 RBP2 MTTP APOB ADFP SLC27A4 PMC4993159__F1 Hepcidin Regulation in the Anemia of Inflammation STAT3 HAMP HFE IL6 TMPRSS6 HFE2 PMC10475367__F2 Kyoto Encyclopedia of Genes and Genomes pathway of target genes in CRC BAX CASP9 MSH6 DCC BAD MSH2 MSH3 SMAD2 APC AKT3 CYCS GSK3B BRAF SMAD4 CTNNB1 CASP3 CCND1 PMC5709727__F7 TNF‐p100 pathway subverts noncanonical NF‐KB signaling in inflamed secondary lymphoid organs LTBR RELB TRAF3 TRAF2 PMC5115901__F10 Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury RASGRF1 LPA PRG3 ARHA PMC2758233__F2 P75NTR-mediated signal transduction pathways JUN ARHA TRAF6 PMC4340752__F1 UPR, autophagy and mitochondria crosstalk underlies the ER stress response ATG10 ATG3 ATG16L1 ATG12 ATF4 ATG5 PMC7615304__F4 Germline and somatic mutations associated with primary aldosteronism KCNJ5 CYP11B2 CACNA1H VAPA GNA11 MC2R ATP1A1 LHCGR CTNNB1 PMC2225459__F2 Schema illustrating the effects of (a) metformin- or AICAR-induced AMPK activation, (b)adiponectin, and (c) TZDs or PPAR alpha ligands on the rat granulosa cell steroidogenesis NR1C1 STAR IGF1 ADIPOR1 ADIPOR2 IGF1R PMC5706455__F4 Red Carpet for Iron Metabolism ERFE BMPR2 STAT3 TFRC TFR2 ACVR2A IL16 HFE IL6 TMPRSS6 IL6R HFE2 PMC8924081__F4 G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN GPR34 PTEN SRC PMC2276852__F7 Schematic representation of the proposed events triggered by exposure to replication inhibitors such as APH ATR BLM PMC3110730__F1 Wnt signaling and regulation of Beta-catenin in tumorigenesis APC CREBBP TCF4 CCND1 CTNNB1 PMC5403405__F7 Proposed mechanism for oridonin-induced G2/M arrest and apoptosis in prostate cancer cells CDC2 BAX MDM2 PMC7674641__F1 Metabolic pathways connected to protein prenylation ACLY ACSS2 IPP HMGCR ICMT ARHA RCE1 HEL-S-26 PMC6771146__F3A Pituitary Transcriptional Response Related to Feed Conversion in Pigs KMT2A MED12 EP400 SETD1A HCFC1 MLL2 CREBBP EP300 NCOA6 SETD1B SMARCA4 PMC10778733__F3 Visualization of CAC-related genes and their functional cross-talks LTBP1 STAT3 PPARG SELPLG CCR2 GSK3B VTN MAP3K14 IKBKG HDAC3 GNAS MYLK PLAT NTF3 NLRP3 QPCT TLR4 CHUK ANKRD11 BIRC3 NOS2 SLC5A1 NGFR ORM1 PLG SNCA AREG MMP9 TNF NR3C1 CAPNS1 SORT1 NFKB1 RELA IKBKB ADRB2 SIRT1 SELP PMC4383151__F1 Metformin action to inhibit cancer STK11 MTOR SRC PMC3670858__F1 Acetylsalicylic acid metabolic pathway ACSM2B SAG HEL-S-5 CYP2C9 PMC10778733__F7 PPI is related to adipocytokine signaling PPARG NOS2 ADRB2 PMC12249733__F5 Involvement of the DEGs of NC and IC associated with effects of ACTH(6-9)PGP peptide a day after IR conditions in striatum NTS CCK C3AR1 NFATC2 PIK3CD SLC32A1 NMU ADRA2A MMP3 GAD2 OXT CACNA1A TNFRSF11A P2RY1 FGF22 VAV3 PDE10A JUNB PENK GRIK1 IRF7 FOS GABRA3 THBS4 CXCR4 CYBB AVP MAPK11 ATP2B4 IKBKE GABBR2 UCN2 ABCA1 NCF1 OLR1 SSTR2 GABRA5 LYPD6B NR1A2 GDNF SELE KCNJ6 CALCR HAP1 CAMK2D LILRB4 SCAP2 CRHR2 MCU CD8A SELP PMC5910405__F1 Our multi-omics integrative analysis of the monolignol biosynthetic pathway in P TH POMT2 CCR2 PMC9336020__F1 Myricetin: targeting signaling networks in cancer and its implication in chemotherapy STAT3 BAX HAMP ARC MTOR TRAF6 MYC PMC5897502__F1 Antigen receptor signaling in naïve and anergic B cells SYK PTPN22 CSK PTEN LYN PMC5819928__F1 EMT activation via TGFB CDH2 SMAD2 VTN SMAD4 TWIST2 ZEB2 ARHA PMC7685798__F7 Reanalysis of 14 designated genes via KEGG pathway enrichment CDK7 PCNA SMC3 CDK2 ORC1L MDM2 ORC3 MYC SKP2 ORC2 PMC5519084__F5 Activation of aromatase promoter I.4 and promoters I.3/II in breast adipose fibroblasts and promoter I.7 in breast endothelial cells STAT3 GATA2 SF1 SP1 PI3 CRTC2 ATF2 CREB1 PMC8137893__F1 Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma CDK6 BRAF NRAS CCND1 CDK4 PMC6650552__F6 AnvM-mediated regulation and its interaction with host cell TLR5 TRAF6 IL1B PMC6136787__F4 Newborn blood DNA epigenetic variations and signaling pathway genes associated with Tetralogy of Fallot (TOF) MEI1 PIR ME1 PMC9632414__F1 Editorial: Dissection of the molecular basis of fatty acid composition in oil crops and molecular breeding of oil crops with improved fatty acid composition LPA FAS SNRK DGAT2 PMC4764103__F1 The CoA biosynthetic pathway PPCS PPCDC PMC6878783__F2 Astaxanthin improves insulin sensitivity and glucose uptake RAB10 RAB14 RAB13 RAC1 IRS1 PMC5102108__F7 Hypothetical model of macrophage-to-Huh7 cell transmission of TLR3-induced anti-HCV activity by exosomes TLR3 DROSHA PMC6789757__F5 Mitogen-activated protein kinase (MAPK) signaling pathway and related miRNAs MAX MPL MEA1 FAS REN TRADD CD14 NLK DAO FLNA TRAF2 PMC3809754__F1 Biogenesis and function of microRNAs DGCR8 PAN2 CCR4 EIF6 DROSHA PMC10971110__F3 Immune response and gene expression through the NF-kB signaling pathway in sepsis CD40 CD80 TLR1 TLR3 TLR4 TLR9 TLR5 TLR7 CCL2 LBP MYD88 PMC4751587__F2 PI3K/AKT/mTOR signaling pathway and a proposed model for its regulation through the evaluated miRNAs ERBB3 RHEB TSC2 TSC1 ERBB2 PTEN MTOR DEPTOR IRS1 EIF4E PMC9289477__F1 Neonatal Innate Immune Response to Sepsis: Checkpoint Proteins as Novel Mediators of This Response and as Possible Therapeutic/Diagnostic Levers ZAP70 FYN LAT APC LCK PMC8514054__F1 JAK-STAT pathway mutations and variants in human disease STAT3 STAT1 STAT5B STAT2 JAK3 EPO TPO STAT4 JAK1 TYK2 PMC5818603__F1 Chromatin structure of human and mouse telomeres DNMT3B POLD3 TET2 ZSCAN4 TET1 TET3 SETDB1 RIF1 SUV39H1 TPP1 PMC9268676__F2 Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms IL10 IL13 IL4 IL6 PMC7387847__F10 Nrf2/SIKE-mediated hepatic injury induced by long-term PM2.5exposure TBK1 KEAP1 GCLM GCLC PMC7584080__F1 Pathway map highlighting all seven genes modified during this study in red MAEA TH MAL CIT PMC7162985__F1 AKT-mTOR signaling pathway RHEB TSC2 TSC1 DEPTOR PMC11700868__F1 Scheme of establishment and application of Nano-IFNG/Zole for remodeling the suppressive TIME induced by iRFA IFNG NOS2 STAT1 IFNGR2 IFNGR1 IPP TFEB ARG1 IRF4 JAK1 PMC4034063__F1 Core hypothalamic energy homeostatic circuit and the dopamine reward pathway POMC MC4R NPY ARC AgRP PMC3728801__F1 Canonical and non-canonical NFKB pathways INA RELA RELB PMC8809547__F2 EBV-driven 1C pathway drives nucleotide and glutathione synthesis MTHFD2 MTHFD1 PHGDH MTHFD1L PSAT1 SLC25A32 SFXN1 HEL-S-51e PSPH PMC12003768__F5 Studying the efficacy of JBOL volatile components in idiopathic pulmonary fibrosis (IPF) using GC-MS and network pharmacology NR1H4 STAT3 PIK3CA CYP2A6 RAF1 MMP12 CCR5 HEL111 CCR2 TLR9 CHRM3 ALB MAPK14 MAP3K8 PTPRO MME ALK ALOX5 FLT4 FGFR1 GC SHH MMP3 FLT1 ABCB1 MAPK1 NR1i1 MMP7 NOS2 AGTR1 MIF SCN5A CMA1 GSTM1 IGF1 EDNRA CYP2C9 BCL2 VCAM1 LCN2 PTGIR TERT PDE4B MPO REN ADAM17 TOP2A TNNC1 RBP4 KIT RORB CYP1A1 NR3C1 PTPN22 CXCR1 MEN1 PDGFRA BMP2 CFTR ERBB2 PRSS1 ENPP2 PPARG TYMS CTSG PLA2G2A HMOX1 PRKCA MDM2 SRC PDE4A PLG HRAS BMP1 HMGCR ECE1 TRPC6 HEL-S-22 CDC42 RNASE3 EGFR BRAF IGF1R HTR2A VCP NOX4 MYLK PLAT F2R F2 F3 IL2 ELANE CCND1 IL1B SELE CHIT1 CTRC PDE5A PTPN11 MMP9 PTGS2 NFKB1 RPS6KB1 NFE2L2 CASP3 XDH MAP2K1 S100A9 PMC4754612__F1 Stimulator of interferon genes (STING)‐mediated cytosolic DNA sensing pathway TBK1 CGAS DDX41 IRF3 AMFR DNASE2 PMC9693028__F3 Antioxidant Properties of Hemp Proteins: From Functional Food to Phytotherapy and Beyond KEAP1 IL1B PMC9901261__F1 Emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor SYK ADAM17 ADAM10 SRC PMC6618772__F1 Simplified metabolism of thiopurines in a target cell TG TPMT GPT PMC9656488__F2 DNA Repair Mechanisms, Protein Interactions and Therapeutic Targeting of the MRN Complex ATR RAD50 MRE11A CHEK2 CHEK1 ATM PMC8071014__F2 Glucose and lipid metabolism in TAMs CD36 ARG1 MGLL PMC7017203__F4 ING proteins are involved in the DNA Damage Response MRE11A BRCA1 ING5 RNF8 ATM ING1 MDC1 PMC4795487__F5 KEGG pathway analysis., The integrated pathway showing the interactions of differentially expressed proteins in apoptotic and survival pathways CASP9 BAD TRADD IL3 CASP12 CASP3 ATM TRAF2 FADD PMC8800112__F3 New blood-based RNA signature (R9), for monitoring effectiveness of tuberculosis treatment in a South Indian longitudinal cohort POR ANXA3 BATF2 TRIM2 SNCA APP SOCS3 SDC1 MMP9 TNF BCL6 UNK PMC8899158__F9 CTNNAL1 participates in the regulation of mucus overproduction in HDM‐induced asthma mouse model through the YAP‐ROCK2 pathway MUC5AC ROCK2 IL4 PMC2577004__F1 Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-ALL MAX FBXW7 MAML1 PTEN MTOR MYC HES1 NOTCH1 PMC3085544__F1 Intracellular signaling by the leptin (LepRb - cyan) and insulin receptor (magenta) STAT3 TSC2 TSC1 SOCS3 GRB2 PMC8786676__F3 Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation CD44 BAX SPARC BCL2 GRB2 MYC TNFSF10 CCL2 TNF SELP PMC8739787__F2 HIF-1A Is a Rational Target for Future Ovarian Cancer Therapies STAT3 BAX SIK2 MMP2 PFKL MMP9 MTOR NPTX2 VHL PMC11172598__F1 Gene interaction network map of each group ALDH1A2 KIN PMC9131029__F2 Plasmalogens and Photooxidative Stress Signaling in Myxobacteria, and How it Unmasked CarF/TMEM189 as the Δ1′-Desaturase PEDS1 for Human Plasmalogen Biosynthesis AGPS PEDS1 GNPAT FAR1 PEMT GPD1 PMC12021866__F7 Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation DLL4 HES1 SIRT1 NOTCH1 PMC9360701__F2 Hypothesized neuroprotective effect of minocycline against COVID-19-induced stroke and neurological dysfunction: possible role of matrix metalloprotease signaling pathway MMP14 PLG MMP2 MMP3 MMP9 FURIN IL1B PMC6678131__F6 Role of LOXL3 in tumor HDAC1 PKD1 RAD51 MSH2 LOXL3 BRCA2 SMC1A HDAC2 CCND1 NUMA1 PMC2706143__F3 Endoplasmic Reticulum and the Unfolded Protein Response CASP9 CASP12 CASP3 ATF4 TRAF2 PMC4452354__F1 Schematic illustration of the transduction of signals from inflammatory bone diseases to brain-resident microglia through the leptomeninges and two different pathways for the IL-1B production activated by CGA and AB in microglia CGA NLRP3 IL16 TLR4 IL1B PMC4054417__F3 Distinct regulation of apoptosis pathway genes in neurons and fibroblasts in response to VZV infection BAG3 TRADD MCL1 CYCS NFKBIE BCL2 APAF1 TRAF2 NFKBIB FADD MYD88 PMC4817280__F2 Partial biosynthesis pathway for major brain gangliosides ST3GAL5 ST8SIA1 PMC2706143__F2 The Endoplasmic Reticulum and the Unfolded Protein Response ATF4 EIF2A XBP1 PMC3565264__F4A Quantitative Profiling of DNA Damage and Apoptotic Pathways in UV Damaged Cells Using PTMScan Direct NAPA MAX ATR feat PCNA ATM RRAS HP BLM RADIL PMC8786676__F6 Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation CD44 MCL1 SELP PMC3017607__F2 The kinetic framework for programmed –1 ribosomal frameshifting POR EPO PMC5006677__F1 The Akt/mTORC1 signaling pathway leading to accelerated translation and increased protein synthesis RHEB TSC2 TSC1 IGF1 IRS1 PMC6101557__F1 Inflammatory caspases (caspase-1 and caspase-4/5/11) are activated through canonical or non-canonical inflammasomes, triggered by microorganism infection IL18 AIM2 IL1B PMC2374589__F1 Programmed cell death can be executed via extrinsic and intrinsic pathways depending on the stimulus leading to apoptosis HTRA2 DIABLO PMC7432699__F7 Schematic summary of the miR-targeting of RSU1 RSU1 HEL-S-28 PTEN ATF2 PMC8306961__F3 Arginine Signaling and Cancer Metabolism ELF4 MFN2 GSK3B ELF2 ATF4 ASNS MTOR TEAD4 PMC8306961__F2 Arginine Signaling and Cancer Metabolism RHEB GPRC6A SLC38A9 PMC7935942__F5 Expanding the drug discovery space with predicted metabolite–target interactions GPBAR1 IL17A PLCB3 PMC8306961__F6 Arginine Signaling and Cancer Metabolism STAT3 SYK TREM1 ASS1 BTK AXL CCR2 GSK3B BRAF MTOR MYC CCL2 PMC2578840__F8 Proposed signaling pathway SMAD2 SMAD4 PMC6637848__F9 L-proline-mediated differentiation of mESCs to EPL cells ATF4 MTOR EIF2A PMC6637848__F7 Cell signalling events that mediate the switch between self-renewal and differentiation in mouse embryonic stem cells STAT3 FGF7A BMP4 LIF DUSP9 GRB2 MTOR ID1 PMC3798256__F1 Pathways involved in stem cell hemostasis via regulation of nutrient sensing TSC2 TSC1 PTEN SIRT1 PMC3089033__F8 Diagram of the proposed cell survival signaling pathway in ER+ breast cancer cells with PI3KCA mutations and low phosphorylated Akt BAD FOXO3A FLII PMC6836728__F5 Schematic representation of the proposed intracellular trafficking pathways of NPRA through the multi-organelle systems in cell compartments: GC PMC5037386__F5 Gene expression profiling reveals aryl hydrocarbon receptor as a possible target for photobiomodulation when using blue light CYP1A2 TRADD KEAP1 ALDH3A1 EGFR CDKN1B AHR AHRR CYP1B1 SRC CYP1A1 PMC2869518__F3 Proximal signaling events in the TCR-coupled signaling pathway CDC42 LAT GRB2 LCK PMC8329526__F2 Context-Dependent Roles of Claudins in Tumorigenesis BCL9 EPCAM RUNX1 SMAD2 APC GSK3B PTEN TAF9 MYC SPX HES1 TYK2 PMC5823598__F1 Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis GPHN FLCN PDK2 TNS1 PRKAA1 FBXO32 PLEK MAPKAP1 RHOD NRAS VPS18 FOXP2 KDR DMD GHB2 UNK RRAGA MAF1 MEFV RPTOR CDC73 RRAGB RRAGD IGF2 RHEB GTF3C2 STK38 BYSL RICTOR GCS1 ATG12 RPS6KB1 VPS41 PRKAA2 NGDN PREX2 BIK PMC7563273__F1 The activation and regulation of the PI3K/Akt/mTOR signaling pathway RHEB RPS6 TSC1 PTEN DEPTOR IRS1 EIF4E PMC3317163__F2 One-carbon metabolism AS3MT HEL-S-61p MTR PMC7563273__F3 Targeting the PI3K/Akt/mTOR pathway in AML RHEB RPS6 TSC2 TSC1 PTEN IRS1 EIF4E PMC9447342__F7 CircPRKCH modulates extracellular matrix formation and metabolism by regulating the miR-145/HGF axis in osteoarthritis HGF MMP3 PMC4712330__F3 PTEN tumor suppressor gene and its role in lymphoma pathogenesis RHEB TSC2 RAN RAD51 NEDD4 MVP PTEN MTOR CENPC IRS1 PMC4367908__F2 The network of molecules involved in the control of VPC fate determination and the cell cycle in C EFL1 CDC2 APC CDK2 CDK4 PMC4712330__F4 PTEN tumor suppressor gene and its role in lymphoma pathogenesis SYK BCL10 CARD11 CD19 PTEN MTOR PMC8909472__F2 Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance HRAS CDK6 GRB2 MTOR KRAS CDK4 PMC7684877__F6 Putative mechanism by which metabolite secretions of L MMP2 MMP9 VEGFA PMC7873381__F1 ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis PPARG APC GSK3B AXIN1 CSNK1A1 CTNNB1 PMC11354764__F3 Three main UPR pathways induced by ER stress ATF4 EIF2A IRS1 PMC11354764__F2 Main pathways involved in the development of insulin resistance RHEB TSC2 JUN PTEN GRB2 GRB14 IRS1 MYD88 PMC11354764__F1 Insulin signaling pathway RHEB CRK TSC2 BAD CBL GRB2 IRS1 PMC12111366__F1 Hemp iron plays a role in muscle regeneration, lipid metabolism, and cholesterol management BMP6 TFR2 HFE HFE2 PMC3885992__F5 Polarization of immune cells in the tumour environment by TGFB SMAD2 SMAD4 PMC8125586__F3 Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics CYP2R1 CYP27B1 CYP24A1 CYP3A4 PMC7815509__F1 Oligodendrocyte lineage cells and depression BRD7 MOG MBP PDGFRA PC OLIG2 SOX10 NOTCH1 PMC3757382__F1 Modified Fearson and Volgenstein Model APC BRAF SMAD4 KRAS PMC4529978__F1 ROS-dependent cellular senescence pathways in MSCs DNMT3B HMGA2 SIRT1 PMC3443885__F3 Molecular interaction between estrogen and thyroid hormone STAT1 SRC PMC3930904__F1 Global view on the intracellular proteome profile change in P HEL60 AOX1 HEL-S-68p HEL-S-49 FBP1 HEL-S-32 ENO1 PMC7143281__F4 Tricarboxylic acid (TCA) cycle showing differences in gene expression and metabolite abundances in mouse liver ACO2 IDH3B CS PDK3 PDK2 SDHD PDHX SDHA SDHB PDHA1 DLAT PDK4 SUCLA2 OGDH SUCLG2 DLD HEL-S-32 PDHA2 MDH2 SDHC PMC4595469__F7 Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells EGFR MICA MICB PMC7564814__F2 Intracellular cytoplasmic pattern-recognition receptor RIG-I is essential for the control of RNA virus infection MAVS STAT2 IRF9 IRF3 IRF7 MYD88 STAT1 TRIM25 NLRP3 TLR3 IFNAR2 IFNAR1 TYK2 PMC11696735__F5 Biosynthetic pathway of steroidal saponins in P EBP DHCR24 DHCR7 FDFT1 TM7SF2 PMC9203969__F1 NRF2 in Fibrotic Diseases: From Mechanisms to Therapeutic Approaches KEAP1 PMC4369322__F1 A model for the integral role of the Rad6 DNA damage tolerance pathway in coordinating the activities of Fanconi anemia (FA) network and homologous recombination repair (HRR) pathway in interstrand DNA crosslink (ICL) repair RAD18 FANCD2 RAD51 PCNA BRCA1 BRCA2 FANCL PMC3714590__F5 Known and Predicted Interactions between the Products of the 352 Genes Bound Preferentially by Pol II in Neuroepithelial CellsAnalysis was performed using STRING with a medium confidence score of 0.4 and all interaction methods available SHF TRAF4 GOT2 CCS EGFR NOTUM GCM2 MMP2 RHO PS1TP5BP1 PMC11950302__F8 Simultaneous targeted delivery of doxorubicin and KRAS suppression by a hybrid molecule containing miR-143 and AS1411 aptamer BAX NCL PMC2782644__F5 Differentiating Human Multipotent Mesenchymal Stromal Cells Regulate microRNAs STAT3 CBL TGFB1 NFKB1 HCFC1 PDGFRA AHR MYC FOS PMC11975384__F1 Comprehensive examination of the Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC5239825__F4 NRF2 as a hub connecting proteotoxic-derived emergency signals to a protective transcriptional response PSMD4 PSMD11 PSMB6 PSMD12 HEL-S-91n KEAP1 PSMB3 ULK1 GCLM PSMC1 ATG2B PSMA4 PSMB2 POMP PSMD7 PSMA2 HEL-S-276 PSMD13 PSMD1 GPX8 PSMD5 GCLC ATG5 PMC7178451__EV1 STAT3‐dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer IFNG GFAP TIMP1 HEL-S-133P INA EPO MIF VHL PMC6304530__F1 The reprogramming of metabolism in cancer GLS IL16 PTEN MTOR MYC PMC6982088__F1 Cyclic production of melatonin, from external (e.g., pineal and possibly extrapineal sources) or internal uterine sources, is responsible for promoting decidualization and improving implantation GDF10 STAR ERBB4 LIF AANAT IHH ASMT PTGS2 BMP6 HBEGF CYP11A1 GDF15 BMP4 BMP2 PMC3689263__F2 Signaling mechanisms important for endocrine resistance and which are currently targeted in clinical trials, combined with aromatase inhibitors EGF IGF1 SRC CDK4 PMC8619591__F1 Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis IFNGR2 IFNGR1 IFNAR2 IRF9 IFNAR1 IRF1 MTOR JAK1 TYK2 PMC5339807__F4 Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling TH MME CLU HK2 LEPR PMC3353781__F8 Signaling pathways mediating Beta-adrenergic effects on the cardiac microtubule network PAK1 MAP4 PMC2911442__F5 WRN participates in the regulation of PCNA mono-ubiquitination and subsequent TLS through interaction with PCNA RAD18 PCNA WRN ATM PMC7372553__F9 CTNND1 function in systemic disease ARHA CTNNB1 PMC7004516__F3 Association of efficacy of 5‐fluorouracil (5‐FU) and metabolic changes in cultured colorectal cancer cells ACLY ACSL6 FH ENO2 IDH3B LDHB ACACA PCK2 RPE SDHB DLAT SUCLG1 RPIA SUCLA2 ACAT2 PFKP HEL-S-49 PC DLD HEL-S-32 MDH2 HEL-S-26 PFKM PMC5541032__F3 Antibody-dependent enhancement (ADE) of Zika virus (ZIKV) and strategies to limit it STAT1 IL10 IL6 PMC6491625__F5 Network analysis of Ly6D, Ly6E, Ly6K, and Ly6H genes LY6D CD27 ALB IFNG FOSL2 RARA RARB AHR IL2 LY6K CEBPB CREB1 PAX3 JUN CD2 LY6H TEX101 BLNK VEGFA LY6E TNF FOS NR1C1 FOSL1 HLA-C CD8A CD3E PMC4465499__F4 Plasma Proteomic Profiling in Hereditary Breast Cancer Reveals a BRCA1-Specific Signature: Diagnostic and Functional Implications RARA HSF1 FGA ACD INS MGMT PMC4556940__F8 Network representation of microRNA ACLY NTS GRIA3 COQ7 GRIA2 HEL113 TNFRSF1B LTA PANX2 TGFB1 CCL3 CCR5 TNFRSF1A PTGR1 CRH GAD1 ACADM NOX4 LTB4R PTGS1 RGS1 AQP4 PTGER3 JUN ACVR2A HEL-S-133P PYGB DBH NGFR GABRB3 PTGS2 TNF NR3C1 HEL-S-8a IL1RN FOSL1 RGS4 FGFR3 AGTRAP CD200 SLC1A2 CALCA GJA1 PMC4465499__F3 Plasma Proteomic Profiling in Hereditary Breast Cancer Reveals a BRCA1-Specific Signature: Diagnostic and Functional Implications TH UBC C2 APOE FGA HP AEN HLA-A PMC8889667__F1 Targeting PD-1/PD-L1 pathway in myelodysplastic syndromes and acute myeloid leukemia MYC S100A9 CCND1 PMC3100722__F1 The neuroendocrine (a), limbic (b), and brainstem (c) inter-related, stress-activated corticotropin releasing hormone (CRH) loops CA3 NTS HEL-S-11 PMC8266859__F8 Possible role of BA3/A1-crystallin in the EGFR signaling network and RPE polarity RPE CRYBA1 EGFR PMC8889667__F2 Targeting PD-1/PD-L1 pathway in myelodysplastic syndromes and acute myeloid leukemia CCND2 TLR4 MUC1 CD200 PMC9687343__F5 Cancer Metastasis and Treatment Resistance: Mechanistic Insights and Therapeutic Targeting of Cancer Stem Cells and the Tumor Microenvironment COX2 CTNNB1 PMC6561919__F7 ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation ATR PCNA REV3L PMC9687343__F4 Cancer Metastasis and Treatment Resistance: Mechanistic Insights and Therapeutic Targeting of Cancer Stem Cells and the Tumor Microenvironment LRP6 MTOR ACE2 CTNNB1 PMC7078475__F1 Biochemical pathways involved in central carbon catabolism in P SDHD MAEA SDHA SDHB MAL FBP1 ENO1 SUCO TNLG7C CIT PMC8566972__F3 Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond IFNG TBK1 CCL3 IRF1 IL2 IRF3 IRF7 CCL5 MTOR PARP1 PMC3733021__F1 Schematic diagram of the ZFN, TALEN, and CRISPR/Cas9 genome editing tools DOK1 TIGIT APC CSK BTLA LAG3 PMC8634046__F7 Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NFKB signaling HDAC5 IL6 TNF PMC3829921__F1 Small GTPases as regulators of cell division ARF6 RAB35 RAB21 PMC1904229__F12 Schematic model of Zfra/WOX1 involvement in TNF signaling TRADD TRAF2 FADD PMC6907041__F7 PBR-BuOH suppressed IgE/Ag-mediated allergic responses that are initiated by FcERI signaling pathway SYK FYN GAB2 PMC7694686__F1 Summary of MEMO1′s role in a variety of signaling pathways, including the: (A) ERBB-family, (B) FGFR-family, (C) IGF1R-family, (D) estrogen receptor and (E) PDGFR and S1P/S1PR families CLASP2 APC GSK3B IGF1R ARHA SRC PMC8533565__F1 Virus-Induced Tumorigenesis and IFN System STAT3 IFNE CGAS STAT2 CRKL TLR9 IRAK1 IRF3 IRF7 MTOR TRAF3 TRAF6 IRAK4 MYD88 STAT1 TLR3 TLR4 SLFN5 TLR7 JAK1 TYK2 RET PMC2764428__F4 MiRNA/TF-mediated regulatory pathway associated with tumorigenesis PAX3 STAT3 MYB BACH2 E2F3 TFAP2A TBP MYC HOXC8 BCL6 PMC9259489__F3 Intestinal epithelial cell mitochondria serve as metabolic signaling platform translating microbiome-derived signals into mucosal responses ECSIT SLC22A5 MAVS ATG16L1 PPIF NLRP3 LRRK2 HEL-S-67p IRGM NOD2 TRAF6 PMC2559887__F3 Ingenuity pathway analysis on NFKB related gene network LTBP2 ZFP36 RPS6 DBP THBS1 ADORA2A GADD45G JUNB SPARC NR1C2 NDUFA13 PECAM1 SLC37A4 HEL-S-166mP DBI TRAF5 GADD45B A2M CPT2 PMC2559887__F2 Ingenuity pathway analysis on AP-1 related gene network KRT18 JUND ICAM3 ID2 MCL1 KLK3 COX7C SPDEF MIF IL6 ARHGEF3 GNE COX8A BTG2 RHOT1 UNK PMC3541122__F6 MiR-29 family is involved in multiple cellular processes STAT1 CDK6 PMC9277821__F2 Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance MAPK1 MAP4K1 IGF2BP3 APC PIK3R1 KHSRP VEGFA MYC YAP1 CTNNB1 STUB1 VHL CD44 INHBA KAT7 FOXO1 GC CNBP PMC5645395__F6 Illustration of the cooperative regulation of a miRNA module that contains four miRNAs: miR-18a-3p, -320a, -193b-3p, and -92b-3p (pink diamonds) MAPK1 BAD PARVG FLNB VAV2 PIK3R3 PIP5K1C PAK4 PTEN SHC2 ARHA LAMB1 FLNA HRAS CRK FYN ACTN4 HEL-S-80p PAK1 RAPGEF1 PRKCA TLN1 CCND1 PMC5645395__F5 MiRNA-mediated gene regulation involved in two functional pathways in the early stage of KIRC and KIRP (miRNAs: pink diamonds; genes: ellipses) STAG2 CREBBP NRAS ATM PTEN EP300 MYC PMC9607910__F1 Applications of Exosomes in Diagnosing Muscle Invasive Bladder Cancer RB1 CDKN2A FGFR3 TERT PMC5693858__F10 A schematic of the mechanism of Panax notoginseng root (PNR) in its enhancing of antiviral interferon-mediated immune responses and natural killer (NK) cell activity TBK1 STAT1 IRF3 JAK1 TYK2 PMC4498560__F1 HPVs infect host epithelial cells (keratinocytes) by interacting with different cell surface receptors such as integrin and heparan sulfate proteoglycans (HSPGs) EGF EGFR MTOR PMC5966753__F7 Action of testosterone (T) in inducing hepatic steatosis/steatohepatitis TG FAS NR1C1 DGAT1 EIF2A XBP1 CPT1A TRAF2 PMC4108232__F1 Mitochondrial dysfunctions in cancer FH HEL-S-62p CS PMC3583171__F3 Significantly differentially expressed genes identified by KEGG as involved in toll-like receptor signaling MAFK TIRAP CD14 FADD PMC9326066__F2 Single-Cell Metabolomics in Hematopoiesis and Hematological Malignancies LPL ASS1 FAS GLS HEL-S-133P CD36 HK2 ASNS HEL-S-26 PMC5430701__F1 Chemokine signalling pathway (source-http://www.kegg.jp/kegg/kegg1.html) ITK ARHA GRB2 SHE DAO DOCK2 PMC7361144__F3 Type I interferon pathway during SARS‐CoV infection and modulatory mechanisms, PLpro excluded TBK1 STAT1 MAVS STAT2 IRF9 IRF3 TRAF3 JAK1 TRAF6 PMC3917856__F6 NRF2-KEAP1 Pathway Is an Early Responsive Gene Network in Arsenic Exposed Lymphoblastoid Cells JUN ABCB6 AOX1 HEL-S-107 PPIB GCLM HEL-S-94n VCP USP14 GPX2 TXN FTH1 CCT7 FTL EPHX1 GCLC CLPP ATF4 HEL-75 UBB PMC10258460__F1 Novel Metabolic Detour for Pancreatic Cancer Survival SMS KLF6 SRM KRAS PMC7774460__F2 RT induces local immunogenic effects IFNG CDA TNF PMC7748218__F6 Model showing contribution of CXCR6-CXCL16 axis in overcoming the effect of DTX: STAT3 EGF BAD CXCR6 TGFB1 GSK3B CXCL16 ADAM10 IMPACT CTNNB1 PMC6288349__F7 Signaling in HIV-1-mediated inflammation NLRP3 CCR5 HLA-C CXCR4 IL1B PMC9213747__F2 Malignant Myeloid Leukemia by Mesenchymal Stem Cells TGFB1 AXL CXCL1 HEL-S-28 MIF ARC CTNNB1 CD74 ANGPT1 COX2 MSC VCAM1 IL8RB IL1B PMC9637482__F8 Cigarette smoke-promoted increases in osteopontin expression attract mesenchymal stem cell recruitment and facilitate lung cancer metastasis CD44 STAT3 MSC PMC12124685__F11 HIV-1 infection stages, deregulated miRNAs, targeted hub genes, and principal enriched signaling pathways in macrophages MTOR PMC5979540__F7 Signalling pathways regulating pluripotency of stem cells regulated by detected differentially expressed miRNAs depend on muscle mass INHA APC SOX2 MSC KRAS TEF PMC5979540__F6 Hippo signalling pathway identified as the most regulated by detected differentially expressed miRNAs depends on muscle mass NKD1 APC GSK3B DLG4 DVL2 AREG MYC TGFBR2 FRMD6 NID1 AFP AMOT PI3 BMP4 SCRIB AJUBA WNT9A YWHAZ PMC6203874__F1 Cholesterol-dependent cytolysin GGPS1 HMGCR FDPS FDFT1 PMC4621609__F10 Schematic of a proposed model for GLP1-mediated signaling pathway protecting cardiomyocytes from PA-induced lipotoxicity CD36 BCL2 CTNNB1 PMC5130051__F2 Engineered nanoparticles induce cell apoptosis: potential for cancer therapy BAX FAS SIRT1 FADD PMC4747889__F3 Highest confidence network constructed with differentially methylated genes by proton beam treatment on the MCF-7 cell ZW10 SLC2A12 HMGCL RPS10-NUDT3 RDM1 RSU1 SUPT20H CASP8AP2 GMFB HEL25 ERMAP GTF2B SLC37A4 UBE2B YBX3 CENPA RRAS CEP97 COMMD1 NKIRAS2 PMC7847386__F1 Nucleic acid-sensing pathways and their evasion by SARS-CoV-2 during COVID-19 infection TBK1 CGAS MAVS ENDOU IRF3 IRF7 MYD88 GSDMD RIGI NLRP3 TLR3 TLR8 TLR7 ACE2 IL1B PMC12190939__F2 Roles of DDR1 in tumor immunology SYK DDR1 CXCL5 PMC8950262__F1 Tissue-Specific Expression of the Terpene Synthase Family Genes in Rosa chinensis and Effect of Abiotic Stress Conditions IPP MVD MVK PMC5948768__F12 ATP6AP2-induced neural differentiation GAL GFAP ATP6AP2 PMC7815874__F1 Increasing glycolysis by deletions of kcs1 and arg82 improved SAM production in Saccharomyces cerevisiae HEL-S-68p HEL-S-162eP KL PMC4654653__F2 Implications of microbiota and bile acid in liver injury and regeneration AKR1D1 CYP8B1 GCA HSD3B7 CYP7B1 CYP27A1 AKR1C4 PMC7695834__F8 Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway SMAD1 DKFZp781O1323 BMPR1A PMC4397621__F1 Schematic model of novel inhibitors in Fas-associated death domain-Procaspase 8 interaction and Caspase 3 activation via Caspase 8 TRADD TNF FADD PMC7441375__F9 Action of MPA GC PDE6A RHO PMC1779657__F2 Recent observations on the regulation of fetal metabolism by glucose RHEB TSC2 TSC1 EIF4E PMC5286961__F1 A scheme of the mutant p53–Nrf2–proteasome pathway with chemotherapeutic intervention targeted at mutant p53 and the proteasome KEAP1 BRAF KRAS PMC6556055__F10 Schematic diagram of mechanism on this research KEAP1 NQO1 MAF IL1B PMC6073315__F1 Schematic illustration of hypothalamic regulation of energy homeostasis TRH CRH POMC MC4R PC NPY ARC AgRP MTOR PMC9329830__F1 Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation SPARCL1 GDF15 DPP4 BTC SPARC RBP4 UNG FABP4 LCN2 PMC3224806__F1 Deciphering the role of Th17 cells in human disease CXCL9 IFNG APC CXCL10 PMC6978354__F6 Differential methylation of genes in the B-cell receptor signalling pathway SYK PIK3CA CD79A CD72 VAV2 CD22 CR2 PPP3CA DAO IKBKG PRKCB BTK PLCG2 CHUK IFITM1 BLNK CD19 PTPN6 RAC1 FOS DAPP1 HRAS NFKB1 SOS2 IKBKB NFKBIA LYN MAP2K2 GRB2 PMC7855922__F1 PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective CSH2 BRAF PTEN MTOR PMC6139279__F1 ROS signaling and ER stress in cardiovascular disease ATF4 EIF2A XBP1 PMC6330712__F3 Simplified pathway for the synthesis of the GPI-core (based on Cardoso et al., ) PIGH DPM2 DPM1 PMC12245687__F6 Mechanism of the Wnt signaling pathway APC LRP5 LRP6 CTNNB1 PMC8867516__F1 Rare Autoinflammatory Diseases TBK1 STAT1 CGAS STAT2 IFNAR2 IFNAR1 IRF3 JAK1 TYK2 PMC12245687__F8 Schematic diagram summarizing the mechanisms of intestinal signaling pathways GSDMD ROCK2 NLRP3 TLR4 ROCK1 TLR9 ARHA RHO MTOR TRAF6 MYD88 PMC12245687__F7 Mechanism of the Nrf2 signaling pathway NR1i1 HMGB1 KEAP1 PMC12245687__F4 Mechanism of Rho/Rock signaling pathway ROCK1 ARHA RHO PMC6073797__F9 Mechanisms underlying the effects of Stachys sieboldii (SS) BAX NGF BDNF PMC12245687__F3 Signaling pathway mechanism of TLRs TLR4 TLR9 TRAF6 MYD88 PMC8714987__F8 Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension PIEZO1 NOTCH3 NOTCH1 PMC3246295__F2 Gab2 interactions with binding partners RAF1 TPO GRB2 PMC5411014__F3 Pathophysiology and management of CVD C6 HEL-S-62p C2 VCAM1 PMC5228698__F1 Diagram of genes in the PI3K/AKT signaling pathway PRLR MYB PKN1 SOS1 FGF7B GSK3B IL6R FGFR2 PPP2R5E PPP2R2B FLT4 EPOR OSMR PDGFC FLT1 KDR CASP9 TCL1B COL6A6 LAMB4 ITGA2B IRS1 RHEB MLST8 TSC2 TSC1 IGF1 CDKN1A SOS2 BCL2 THBS4 APIP STK11 FGF14 PKN2 IL2RG IL2RA GNGT2 GNB1 FGF7A COL1A1 LPAR4 TLR4 FGF9 GHB2 FGF16 YWHAG VWF PDGFA KIT RBL2 CD19 PPP2R1A RAC1 KITLG SPP1 FGF7 HEL-S-125m LPAR2 FGF20 IFNB1 GNGT1 IL3 IL3RA GNG12 PRKAA1 PHLPP1 COL4A2 MDM2 PPP2R2C FGF22 IFNA21 GNB2 TNFSF6 PIK3AP1 FGF5C FGF10 EIF4E COL6A1 IFNAR2 CDKN1B IFNAR1 CDK2 GRB2 COL9A2 COMP INS PPP2R3C INSR ITGA6 ATF4 CCND1 FGF23 CDK4 EFNA5 HSP90AB1 RPTOR RPS6 COL1A2 GNG10 COL9A1 G6PC1 XB GYS1 RPS6KB1 PPP2R1B FGFR3 GNG11 IFNA7 IFNA6 IFNA8 IFNA13 IFNA14 IFNA16 IFNA10 MCL1 IF1AA9 EPO MYC LAMB1 COL4A4 CDK6 CCNE1 FGFR1 PKN3 GHR CSF1R EFNA4 IL7R IFNA2 GHB3 ANGPT2 RELN ANGPT4 CHRM2 GNG7 FGF13 FGF12 GYS2 FGF21 GH1 PPP2R5C PCK1 CCND2 YWHAQ PHLPP2 PPP2R3B CCND3 IFNA17 THBS1 CSH2 IL4 LPAR1 ATF6B CCNE2 IL2RB ITGA1 KPG_010 PPP2R2A PDGFRA PPP2R3A IL7 PPP2R2D CDC37 FGF18 PPP2R5A SYK LAMA5 EPHA2 CSF1 OSM GNG5 CRTC2 EFNA1 FGF8 FGF8A BCL2L1 NGF EFNA2 ANGPT1 PDPK1 FGFR4 ITGA2 PRKCA EIF4E1B LAMC2 COL2A1 PCK2 EFNA3 BRCA1 RXRA LAMB3 LAMB2 LAMA3 TNC EGF BAD HGF LAMA1 CHRM1 THBS2 THBS3 VTN IBSP PTEN CHAD MTOR TNR LAMC1 CSF3 ITGAV F2R IL2 PPP2R5D HEL2 PDGFD GNB3 ITGA7 GNG13 ITGA4 GNG4 GNB5 NGFR IFNA4 PPP2R5B BCL2L11 GNG3 GNG8 FGF2 GNG2 PRL GNB4 PRKAA2 YWHAZ PMC5618562__F2 Interplay between G-Protein Coupled Receptors (GPCR) signaling regulated by melatonin and GPCR signaling regulating YAP/TAZ LATS1 RHO TBX5 CTNNB1 PMC4583820__F1 Involvement of IAP proteins and IAP antagonists in the apoptosis and NFKB pathways [, ] TRADD RELB RIPK1 TRAF3 TRAF2 FADD PMC5514949__F7 Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway SMAD2 SMAD4 PMC11685696__F4 Intestinal microbiota mediate CID through the TLR receptor and cGAS-STING pathway TBK1 CGAS LTA TLR9 IRF3 IRF7 IL6 TNF TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 TLR7 PMC5618562__F4 Interplay between melatonin signaling, cell contact-cell polarity complexes, mechanotransduction, and YAP/TAZ LATS1 NOS1AP ARHA TBX5 RAC1 CTNNB1 PMC11685696__F3 Mechanism by which intestinal microbiota regulates intestinal mucosal injury through STING pathways TBK1 CGAS IRF3 PMC5618562__F3 Interplay between melatonin, YAP/TAZ, and metabolic pathways IRS4 TBX5 MTOR IRS1 CTNNB1 PMC4791395__F3 Stealth strategies of Brucella TLR4 ELL PMC4890468__F2 The mammalian target of rapamycin (mTOR) signaling pathway and crosstalk with the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K) pathway TSC2 PHLDA3 TSC1 NF1 EGFR PTEN MYC IRS1 PMC4791395__F2 Strategies of Brucella to evade the innate and adaptive immunity TIRAP TLR4 MAL TLR9 MYD88 PMC8650121__F1 Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol TRPM7 HEL-S-11 TRPC6 MLSN2 TRPC3 PMC1899380__F1 Late steps in corrin ring biosynthesis in serovar Typhimurium APP NDP ADA PMC6493983__F1 Pathways to cellular senescence in eukaryotic cells ACTA2 ATR CDK6 COL4A1 CDK2 ATM CDK4 PMC10384366__F1 Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells SUFU GSK3B SMO HEL-75 CTNNB1 PMC8391142__F3 The Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers STAT3 BRD4 TET1 SOX2 CHL1 EIF5A MTOR PMC3879068__F3 Networks showing metabolic pathways differentially modulated between H and L groups CTSF MPZ RASGRP3 SCD FASN ACACA B3GAT1 ACSS2 THRSP BNIP2 RGS4 APOB ITPR2 HP AHSA1 ELOVL6 PMC8391142__F2 The Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers IL1B PMC4576950__F2 Processing of the Notch signaling pathway and the nuclear cycle SPEN CDK8 FURIN HES1 NOTCH1 HES5 PMC8391142__F1 The Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers CD44 CD24 CYR61 ABCC1 SOX9 SOX2 SMO ABCG2 SKI NOTCH1 PMC9179862__F9 CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis CXCL12 ACKR3 CXCR4 PMC3756614__F11 Signaling pathways used by EGF to stimulate goblet cell proliferation EGF EGFR GRB2 SRC PMC3099575__F5 Model of relationship among Hfe, Tmprss6, and the Bmp/Smad signaling pathway in hepcidin regulation BMP6 HAMP HFE TMPRSS6 ID1 HFE2 PMC3088084__F4 Therapeutic effects can be monitored using DMR on scant cell populations EGFR GRB2 MTOR PMC8915145__F3 Common pathways control autoimmune susceptibility and TFH cell homeostasis TH ICOS LRBA CXCR5 CTLA4 PMC6109707__F8 Complement activation and involvement during alcoholic liver disease HEL-S-62p C2 C4B_2 TNF PMC9658582__F5 Tocotrienol-Rich Fraction and Levodopa Regulate Proteins Involved in Parkinson’s Disease-Associated Pathways in Differentiated Neuroblastoma Cells: Insights from Quantitative Proteomic Analysis POR TH CAST WAS MCU SNCA PMC3499881__F1 Regulation of the polyamines putrescine, spermidine and spermine by biosynthetic enzymes (shown in green) and catabolic enzymes (shown in red) AMD1 SLC3A2 HEL-S-18 SMS SRM SMOX PAOX PMC8749860__F1 BRCA1 and Metastasis: Outcome of Defective DNA Repair RAD51 BRCA1 BRCA2 ATM PALB2 PMC6932941__F3 Diagram of the pathways involved in the metabolic interaction of glycolysis, mitochondrial respiration, and hyaluronan synthesis CD44 OGT CIC PDC PMC3892099__F8 Summary of parthenolide-induced signaling pathway in NSCLC cell lines TNFRSF10B DDIT3 ATF4 PMAIP1 EIF2A PMC8117419__F2 Ferroptosis in Ovarian Cancer: A Novel Therapeutic Strategy GPX4 PMC11983172__F11 Xuanfei Baidu Decoction Alleviated Sepsis-Induced ALI by Modulating Gut Microbial Homeostasis and Promoting Inflammation Resolution: Bioinformatics and Experimental Study GPR18 TLR4 IL6 PMC2939232__F10 Acute hyperglycemia rapidly stimulates VEGF mRNA translation in the kidney. Role of angiotensin type 2 receptor (AT2) EEF2K EEF2 MTOR PMC4033012__F2 Schematic representation of the NALCN channelosome CASR UNC79 UNC80 NALCN PMC9354910__F3 Common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19 LEP F2 CXCL16 AHR CXCL2 HLA-B MTOR CXCL10 HLA-C INS TYK2 HLA-A PMC9252571__F1 Metabolic pathways implicated in ferroptosis TF IBRDC1 SLC39A14 STEAP3 KEAP1 GPX4 PMC6766640__F3 Convergence of the TGFB and collateral signaling pathways regulates transcription of the profibrotic PAI-1 and CTGF genes RASSF6 AZIN2 ID2 PATJ APC SOX2 AREG MYC CTNNB1 LATS1 LATS2 AFP AMOT PMC3666170__F3 Role of Cx43 and Panx1 hemichannels in paracrine signaling in taste transduction PANX1 TRPM5 PLCB2 PMC3046528__F6 Monosodium urate (MSU)-mediated inflammation and the roles of spleen tyrosine kinase (Syk) and Nlrp3 SYK IL16 CARD9 PMC7690394__F1 Folic acid metabolism and 5-MTHF transport across the choroid plexus epithelium in the brain DHFR MTHFS PMC6647482__F3 The interplay between purinergic signaling and ComC activation during sterile brain inflammation HMGB1 S100A9 PMC9146749__F7 Infectious Bronchitis Virus Nsp14 Degrades JAK1 to Inhibit the JAK-STAT Signaling Pathway in HD11 Cells STAT1 JAK1 PMC3351347__F7 Control of Pax3 expression in the caudal neurectoderm via NCE2 PAX3 TEAD2 SHH CTNNB1 PMC6678794__F1 Delta-like ligand 4 (DLL4) and Jagged1 exert different effects on Th subsets differentiation TH DLL4 APC PMC115962__F5 IFNG signaling pathway showing the defects in the human fibroblast mutants B3, B9, and B10 IFNG STAT1 JAK1 PMC6261508__F1 MTOR pathway in treatment of epilepsy: a clinical update STRADA RHEB TSC2 RICTOR TSC1 NPRL2 C16orf35 PTEN DEPDC5 MTOR EIF4E PMC3503525__F1 WNTS AND TGFB IN SYNAPTOGENESIS: OLD FRIENDS SIGNALLING AT NEW PLACES MAP1B APC GSK3B SMAD4 CTNNB1 PMC6079151__F4 WNT pathway promoting endometrial carcinogenesis APC GSK3B CTNNB1 PMC7600741__F3 Ca2+-signaling pathways and HCC cell apoptosis ORAI1 STIM1 MCU PMC9259665__F2 Trends in insulin resistance: insights into mechanisms and therapeutic strategy ACLY TSC2 PDE3B TSC1 FOXO1 ABHD15 GCK PCK1 PMC2712099__F2 The aryl hydrocarbon receptor (AHR) signalling pathway AHR AHRR PMC10984988__F9 Insights from bioinformatics analysis reveal that lipopolysaccharide induces activation of chemokine-related signaling pathways in human nasal epithelial cells SAA1 CSF1 RELB IRAK2 LCN2 TNF CSF3 CCL20 NFKBIZ BIRC3 PMC8727603__F2 Rotavirus Interactions With Host Intestinal Epithelial Cells STAT1 MAVS TLR3 STAT2 IRF9 IRF3 MX1 CXCL10 PMC5746415__F1 Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade CCL7 BTLA PTEN B2M CCL5 FOXP3 CXCL8 LAG3 CTNNB1 PMC9058838__F4 Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway ACHE PYGM ASS1 CDS2 CAD ASL GLS CHPT1 HK2 GPT2 CRLS1 HEL-S-30 PCK1 ADSL PGAM1 PIG59 AGXT HEL-S-68p HEL-S-162eP ENO1 ChAT LPCAT1 HEL-S-87p CHKB PMC3471948__F4 Cross-Species Genome Wide Expression Analysis during Pluripotent Cell Determination in Mouse and Rat Preimplantation Embryos MYLK RALA ROCK2 CCNE1 PIK3R3 NFKBIA GSK3B PIK3R1 MYC SKP2 CCND1 MYLK3 PMC4285772__F7 SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model STAT3 RELA PTEN SOCS3 PMC3916724__F1 Molybdenum metabolism in higher plant cells FES XDH PMC4810800__F2 TGFB1/SMAD signaling pathways in hepatic fibrosis SMAD1 DKFZp781O1323 SMAD2 SMAD4 BMP7 PMC12136530__F8 Proposed mechanism by which arginine inhibits tumor growth ASS1 CAD ASL OTC PMC3594520__F1 TLR3 immunity to infection in mice and humans TBK1 TRADD TLR3 TRIL TANK IRF3 ELMOD2 TRAF3 DDX3X TRIM21 PMC2752832__F7 Scheme for up-regulation of the PAI-1 gene by EGF in glioblastoma EGF EGFR SPHK1 ATF2 SRC CDCP1 PMC6204952__F4 GC-C activation, intracellular effects IFNG CFTR IL1B PMC5800892__F7 TRAF-STOP Treatment Reduces Atherosclerosis and Preserves ImmunityBinding of CD40L to CD40 results in the recruitment of tumor necrosis factor receptor-associated factors (TRAFs), and propagation of signaling CD40 CD80 ELL TRAF6 PMC7014934__F1 An overview of autophagy machinery ATG101 ATG12 ATG5 PMC3969300__F1 Establishment of left/right (LR) asymmetry during development ACVR2B NODAL CFC1B PMC9455056__F4 MYCN and Metabolic Reprogramming in Neuroblastoma PAICS CAD OMP UMPS HEL-S-70p PFAS DHODH ADSL PMC4801062__F3 ZBIT Bioinformatics Toolbox: A Web-Platform for Systems Biology and Expression Data Analysis PDF EGF PDGFA PMC9455056__F3 MYCN and Metabolic Reprogramming in Neuroblastoma MTHFD2 MTHFD1 PHGDH PSAT1 PSPH PMC9655262__F4 Necroptosis: A Pathogenic Negotiator in Human Diseases RIPK3 MLKL RIPK1 PMC11024365__F9 Proposed modeling of antioxidant mechanisms in H MYB CAD PRX PMC8658611__F5 Impact of Cigarette Smoking on the Expression of Oxidative Stress-Related Genes in Cumulus Cells Retrieved from Healthy Women Undergoing IVF USP14 PROX1 GPX2 FTH1 HEL-S-107 CCT7 FTL KEAP1 GCLC GSK3B HEL-75 UBB PMC9455056__F1 MYCN and Metabolic Reprogramming in Neuroblastoma PHGDH HK2 PMC9124882__F2 Recent advances in cancer immunotherapy: Modulation of tumor microenvironment by Toll-like receptor ligands TLR3 TLR4 TLR9 IRF3 IRF7 TLR7 IL6 TRAF6 MYD88 PMC6881706__F1 Circular RNAs Regulate Cancer Onset and Progression via Wnt/Beta-Catenin Signaling Pathway BCL9 DKK1 APC APC2 CCND1 CTNNB1 PMC6348061__F2 Simplified diagram of the acetylcholine (ACh)-signaling pathway in human lung cells ACHE ChAT BCHE PMC6540157__F1 RNA granules and caprin-1-associated tumorigenesis DCP2 AGO2 EIF2A MYC CAPRIN1 CD47 PMC6287147__F8 Schematic illustration of a working model for the TGFB1/SMAD/Snail pathway in modulation of EMT-dependent fibrosis in SGEC SMAD2 SMAD4 PMC10380572__F2 Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients BTK LAT LYN GRB2 PMC7729937__F11 Proposed mechanism of the differential actions of arecoline on cell growth among RWPE-1 (A), PC-3 (B), and LNCaP (C) cells CDC2 CCND3 CCNB1 CCND1 CDK4 PMC8117014__F4 Research Progress of circRNAs in Head and Neck Cancers EGF FOXQ1 EGFR ATRNL1 PTEN CRIM1 APAF1 PMC3961947__F1 Molecular pathways altered by green tea extract IGF1 BCL2 MAP2 PMC6065049__F6 PKC pathway for prolactin regulation of the metabolic genes for citrate-producing prostate cells JUN PRL FOS PMC4689760__F1 Cholesterol biosynthesis pathway is altered in CEM/R2 cells CYP51A1 MSMO1 EBP SOAT2 SQLE SC5D DHCR24 ABCA1 HMGCS1 LIPA IPP HMGCR SOAT1 DHCR7 IDI1 FDFT1 HSD17B7 TM7SF2 PMC6435069__F2 Complement regulators C7 HEL-S-62p C2 C9 CD46 CS C4A C4B_2 PMC6435069__F1 Complement pathways C7 HEL-S-62p C2 CS C4A C4B_2 PMC6609813__F2 Suppressive mechanism of regulatory T (Treg) cells ICOS CD80 FAS APC PDC FOXP3 LAG3 PMC7993742__F3 Protein-protein interaction (PPI) of differentially expressed aging-related genes SNRPD2 HEL-S-79 MMP12 UBE2C MYBL2 FBL CTSS IRAK2 CCNA2 CCL5 MYC PLK1 CXCL8 MMP11 FGFR2 POSTN RHOD ADRA2A ITGA2 DPT FGFR4 CNN2 NPM1 MMP3 A2M PLOD3 GGH DCN FBLN2 MSX2 MMP7 CENPF P2RY1 C7 RPL12 RPS19 B2M LDHB VEGFA CCL13 RPN2 AURKB APOB LCN2 CDC25B CALU RPL35 RPL18 RPL22L1 CDC20 CD36 PCNA CKS2 THBS2 CENPE CDKN2B HEL-S-100n COL3A1 MYLK TPM1 TFRC HEL-S-128m TUBA4A QPCT CCND2 CLU BMP4 ITGA6 LDHD RPS6 MYL6 ETS2 CXCL16 GZMA BMP7 CXCL2 CBX3 SPP1 CHI3L1 CCL28 SERPINE2 PMC9569594__F10 Novel Thieno [2,3-b]pyridine Anticancer Compound Lowers Cancer Stem Cell Fraction Inducing Shift of Lipid to Glucose Metabolism GAL B4GALNT1 PMC4219530__F1 Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation MEFV PYCARD CASP8 CXCL1 CARD6 TNF TRAF6 PYDC1 CCL2 PSTPIP1 IKBKG MAPK3 NLRC4 RIPK2 MAP3K7IP1 NLRP3 IKBKB NOD2 CHUK NOD1 MAPK10 CARD9 IL1B BIRC3 PMC4250958__F1 Differential Apoptosis in Mucosal and Dermal Wound Healing CASP9 CASP8 CASP6 CASP2 TRADD CYCS CASP3 PMC4086428__F4 Predicted network linking pancreatic cancer miRNA markers, known pancreatic cancer genetic lesions, and DAMPs HMGB1 BRCA1 BRCA2 SMAD4 BCL2 ZEB2 KRAS S100B PMC4086428__F3 Three commonly differentially expression MicroRNAs in pancreatic cancer tissue and patient blood: MicroRNAs 21, 155, and 200 SOCS1 TP53INP1 RECK BRAF PTEN ZEB2 MYD88 PMC11652788__F5 TsRNA in neurodegenerative diseases CLP1 NSUN2 PMC6723754__F3 Signaling pathways elicited by stabilin-mediated phagocytosis of apoptotic cells CRK GULP1 RAC1 DOCK1 PMC7669705__F2 Opportunities for combination therapy CDC2 RB1 AURKA NF1 PTEN MTOR CCNB1 PLK1 CCND1 CDK4 PMC8038661__F2 Extracellular regulators of adipogenesis GATA2 SMAD1 WNT3A SMAD4 MTOR GATA3 CTNNB1 GC BMP2 SHH FOXA2 NOTCH1 GLI3 PMC7599682__F2 SRC structure and regulation STAT3 EGFR VTN MTOR PMC10533267__F7 sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway TBK1 IRF3 TRAF3 TRAF6 TNF PMC4835424__F1 Plausible biosynthetic pathway leading to atisine in A PGP IPP HEL-S-162eP PDC MVK PMC5139139__F4 Linking identical processes found between two metabolic maps IFNG IFNGR2 ENG ASL COPE IRF1 PMC5739856__F1 Neutrophils promote tumour growth through direct and indirect mechanisms ARG1 CCL17 PMC2924908__F2 Complement - a key system for immune surveillance and homeostasis CRP APC VTN PMC10474740__F2 Angiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization HBEGF IGF1 FOXO1 CD93 MMRN2 SMAD2 IGFBP7 IGF1R GRB2 SRC IRS1 PMC2729336__F3 Transcriptional control of HC and amacrine cell development PROX1 ISL1 NEUROD1 SIX3 FOXN4 PTF1A BARHL2 PMC10474740__F3 Angiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization CDC42 CRK RAB5C CD93 MMRN2 IGFBP7 ARHA SRC RAC1 PMC10452661__F2 Crosstalk between IL-6 signaling and the PI3K/AKT/mTOR pathway in EAOC ARID1A PTEN MTOR PMC10452661__F1 PI3K/AKT/mTOR pathway-related gene alterations involved in the pathogenesis of Endometriosis and Endometriosis-Associated Ovarian Cancer ARID1A PIK3CA PIK3R1 ERBB2 PTEN PMC11947373__F1 COVID-19-induced molecular mechanisms that propel OSCC development and chemoresistance NLRP3 NRP1 MTOR ACE2 PMC5096733__F1 Simplified diagram of mTORC1 and ERK1/2 signaling following muscle contraction RPS6 EEF2K EEF2 PMC8046170__F3 Human complement cascades CRP C6 C7 C2 C1S C9 VTN C4A C4B_2 CLK1 PMC7882174__F2 Role of leonurine in cardiovascular disease BAD MTOR CP PMC7779461__F5 Chemokine Signaling Pathway Based on DAVID Analysis of KEGG Pathway Database BAD ARHA GRB2 DAO DOCK2 PMC8351522__F2 Biomarkers and targets of mitochondrial dynamics CDC2 BAX TBK1 PINK1 OPA1 PGAM5 APC HUWE1 PHB2 PARL INF2 AMBRA1 OMA1 HDAC6 PMC8351522__F5 Biomarkers and targets of mitochondrial dynamics DGUOK IFNG NLRP3 AIM2 HEL-S-51e YAP1 PMC8351522__F4 Biomarkers and targets of mitochondrial dynamics METTL4 ND6 PAH C1QBP MDM2 PMC10865418__F5 Schematic diagram illustrating the hypothesis of signaling regulation in aGVHD FOXP3 MTOR PMC8351522__F1 Biomarkers and targets of mitochondrial dynamics CDC2 BAX PINK1 OPA1 MFN1 APC SPIRE1 AIM2 MFF HUWE1 PARL INF2 MFN2 OMA1 HDAC6 PMC3136902__F1 IL-1RI signaling JUN MAP3K7IP1 SIGIRR IRAK1 IRAK2 TRAF6 IRAK4 IL1B MYD88 PMC3531074__F3 Network exploration options TES HEL111 UTY PMC6290135__F1 Polyamine biosynthetic pathway in single-celled parasitic eukaryotes TG EIF5A DAP DOHH HEL-S-64p CP PMC7254625__F1 Pathogenesis of non-hereditary brain arteriovenous malformation and therapeutic implications HRAS EPHB4 BRAF MTOR KRAS PMC8928114__F4 Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics STAT3 TRADD JAK3 IL21R IL7R JAK1 TNF IL23R TRAF2 TYK2 PMC3355968__F2 Regulation of Mcl-1 and Snail by AKT, ERK, and IKK signaling pathway GSK3B PIN1 CSN2 PMC3355968__F1 Regulation of FOXO3 and Beta-catenin by AKT, ERK, and IKK signaling pathway FOXO3A MDM2 SKP2 CTNNB1 PMC6433688__F11 Illustration of the FGF16 signalling pathway to regulate Leydig cell development FGF16 PMC2822851__F1 Signal transduction pathway from integrin receptors to actin cytoskeleton CDC42 VASP VAV2 WASL MARCKS RHO FLNA RAC3 DOCK2 SPTA1 ACTA2 EZR FYN WAS DMD SRC HEL-S-15 VAV3 ANK2 DOCK3 CRKL KIT VAV1 ARHA RAC1 DOCK1 HEL114 CRK TIAM1 RHOB DIAPH2 WASF1 DOCK4 LYN WIPF2 ACTG2 PS1TP5BP1 LCK PMC8693951__F1 TLR7 signaling in lupus B cells BANK1 TLR9 IRAK1 IRF7 TRAF6 IRAK4 MYD88 IFNG STAT1 UNC93B1 TASL BCR TLR7 SLC15A4 PMC4792934__F10 Proposed store-operated signaling mechanisms in end-feet of Müller glia STIM1 TRPC1 NACA PMC3857640__F5 Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk STAT3 JAK3 PMC6479272__F13 Partly hypothetical model describing the characteristic shifts of balance within the sphingomyelin/salvage pathway attributed to immune low and immune high tumor subtypes/subgroups of patients SGMS1 SPHK1 SGMS2 SMPD1 SGPP2 SMPD2 CERS6 LPA NAAA SPHK2 SGPP1 CD163 LPAR3 CERS3 CERS5 CERK CERS1 CERS2 CD14 LPAR1 S1PR1 KPG_010 LPAR2 ENPP2 CD68 PMC6880815__F3 Putative biosynthetic pathway to the nanangenines F10 F11 PMC9578081__F5 11-Oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing’s disease HSD3B2 CYP21A2 STAR CYP17A1 CYP11B2 CYP11A1 HSD11B2 CRH PMC7339600__F5 Protein-protein interaction network for the DEGs in the brown, blue and red modules MYLK2 SLC25A5 BCAS2 CD79A GDF8 CARNS1 EGFR NRAP FGF7B NRP1 SLC32A1 FHL2 MYLK4 LXN CD109 NID2 ATP6V1C2 TUBB1 CKMT2 CD93 HEL-S-32 HEL-S-108 AMFR KDR PROC PFKM CA14 EPHX2 HEL-S-117 MCAM CADM2 KIT HEL-S-30 UNC13C GJB1 CYP1A1 TMEM163 MYOM3 CCL13 DENND2C VCX2 PGAM2 SLC18B1 SMTNL1 FBP2 PIAS1 LAMA4 GNG11 PMC4314775__F7 Proposed mechanism of differential regulations of NFKB – miR-29b – p53 pathway by S100A7 in different types of breast cancer cells CDC42 S100A7 YY1 PMC5056381__F8 The anti-hyperglycemic efficacy of a lipid-lowering drug Daming capsule and the underlying signaling mechanisms in a rat model of diabetes mellitus TCF7L2 GSK3B GIP CTNNB1 PMC7339600__F6 miRNA-TF-target regulatory network NR1C1 CKMT2 FGF7B NRP1 COL4A2 COL4A1 KIT HEL-S-32 VEGFA CYP1A1 PMC6412338__F3 mTOR signaling network RHEB EEF2K TSC2 TSC1 SGK1 FOXO1 ULK1 FOXO3A F3 PTEN DEPTOR PMC10916191__F8 Working model of lipid synthesis induces by PPAR and cell cycle regulation in GCs after MLN4924 treatment ACSS2 BAX CDK6 PCNA CD36 EBP FASN BCL2 CCND1 CDK4 PMC5308742__F8 De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells HEL-S-90n FOXO1 NAMPT BCL6 SIRT1 PMC6883191__F2 Evaluation of the immunobiological effects of a regenerative far-infrared heating system in pigs IFNG STAT1 LY96 TLR4 CD14 TRAF6 LBP MYD88 PMC3843070__F5 Model illustrating the potential role of CRKL in recruiting NleH1 to inhibit RPS3/NFKB signaling during A/E pathogen infection MAP3K7IP1 RPS3 CRKL TNF PMC10898168__S1 Inhalable hybrid nanovaccines (NVRBD-MLipo) with virus-biomimetic structure against SARS-CoV-2 infection CD80 TLR4 TNF PMC11554530__F2 Functional plasticity of Tregs and Th17 cells STAT3 TIGIT IL10 IDO1 PTEN FOXP3 PMC6685593__F10 Piezo1 promotes tumorigenesis of prostate cancer PIEZO1 MTOR CCND1 CDK4 PMC8146082__F2 Unfolded Protein Response: An Overview ATF3 ATF4 EIF2A PMC3023029__F2 Intracellular transport pathway of Shiga toxin CDC42 RAB43 EHD3 VTI1A SYK VAMP3 RAB33B ARHGAP21 YKT6 SNX1 ARL1 SNX2 SNX8 PMC7586431__F5 Statin therapy for cancer TF CASP3 ARHA MTOR KRAS PMC7586431__F3 Statin therapy for coronary heart disease MCM7 CDK2 MCM6 ARHA RAC1 PMC6966530__F11 Effect of tyrosine phosphorylation of PDHK1 and PKM2 on the fates of pyruvate and acetyl-CoA in normal and cancer cells (modified according to ) ACLY HEL-S-133P FASN PDC GRB2 PMC3742712__F2 Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection NLRC4 NLRP3 AIM2 IL1B PMC6332483__F6 Schematic model of SNHG6 in CRC cells PMC5907676__F1 Wnt signaling pathway SOSTDC1 PI3 APC ARHA WIF1 CTNNB1 PMC6269119__F1 The activation of an intracellular channel promotes the trafficking and secretion of a cytokine TLR4 CCL2 PMC8263212__F1 Mechanisms Underlying the Role of Myeloid-Derived Suppressor Cells in Clinical Diseases: Good or Bad STAT3 STAT1 APC ARG1 PMC3109490__F1 Francisella tularensis tularensis targets the PI3K/Akt pathway at multiple levels PTEN PMC11524448__F8 T3SS triggered LTB4 synthesis differs between neutrophils and macrophages SYK NLRP3 c-fgr STIM1 SCAP2 LYN PMC6963649__F2 Simplified schematic diagram showing synergistic and antagonistic interactions between the ABA signaling pathway and other hormonal signaling pathways during abiotic and biotic stress MYB ERF MYC PMC3766375__F2 Fat side of Prostate Cancer ACLY CYP17A1 HMGCR CYP11A1 FASN MAL ME1 HEL-S-26 PMC2742086__F2 Functional and structural organization of migratory mesenchymal cells CDC42 APC GSK3B NUMB ARHA RAC1 PMC8946764__F2 Unravelling the Role of Kinases That Underpin Androgen Signalling in Prostate Cancer STAT3 WNK1 CAMK1 EGFR PFKFB2 ADPGK IL6R CDK8 WNK2 CAMKK2 CDK6 MAP2K6 MAP2K4 HIPK2 CAMK2N1 SRPK2 CCND1 MAP2K3 COASY CDK4 CDC2 CNKSR3 HK2 STK39 ERBB2 MAP2K5 CHKA CDK9 PMC5907676__F3 Cross-talk between Wnt and signaling pathways SIAH1 GSK3B EZH2 MTOR CTNNB1 PMC3543749__F2 Telomere maintenance pathway NHP2 NOP10 TERT POT1 TPP1 PMC3543749__F1 Insulin/IGF-1 signaling pathway SOCS1 AKT3 PTEN SOCS3 SIRT2 SKP2 SGK2 SIRT3 PHLPP1 CCND2 INSR CCNG2 PHLPP2 CCND1 SGK1 TNFSF6 RBL2 IRS4 BCL2L11 IGF2 IRS1 IGF1 FOXO1 SIRT1 BCL6 PMC3766375__F3 Fat side of Prostate Cancer ACLY HMGCR HEL-S-133P FASN MAL PTEN MTOR MYC HEL-S-26 PMC3408141__F8 The molecular pathway required for NOD2-dependent autophagy ATG16L1 ULK1 NOD2 PPP2R1A PMC2615558__F4 Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus CASP9 FBN1 FAS TIMP3 CASP8 PLAUR PRRX1 CSF3 SPI1 FOS CD47 HEL-S-99n RBL1 ATF3 PLAT RYBP PMC8467246__F1 Landscape of IFN/ISG Signaling in HIV-1-Infected Macrophages and Its Possible Role in the HIV-1 Latency ISG20 APOBEC3G ALKBH5 USP18 METTL14 YTHDF2 MX2 IRF1 MX1 METTL3 ISG15 CXCL10 PMC7037436__F8 Andrographolide biosynthetic gene activation by MJ elicitation in Andrographis paniculata IPP IPMK MVK PMC7226813__F4 JNK enhances fibrosis via crosstalk with TGFB, PDGF, STAT3, and WNT signaling pathways STAT3 JUN SMAD2 IL6 FOS CTNNB1 PMC7226813__F3 JNK modulates keratinocyte production of inflammatory cytokine/chemokines and recruitment of immune cells in psoriasis IFNG CYR61 CCL20 PMC7226813__F2 JNK regulation of cell cycle progression, cell adhesion, and cell apoptosis BAX JUN BAD TRADD MMP9 CCND1 TRAF2 FOS PMC7226813__F5 Differential roles of JNK1 and JNK2 in skin cancers JUN SHH ATF2 CYLD FOS PMC4973244__F8 Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway STAT3 TLR4 MYD88 PMC6203147__F10 Activation of EGFR/PI3K/Akt signaling pathway LRIG1 BAX PMC8338901__F2 Contributions of EV cargoes in inflammation in CVD FAS CD36 IRAK1 VCAM1 MTOR TRAF6 CD47 MYD88 PMC5745765__F8 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature IFNG TSLP TGFB1 HGF CD1A IL33 PMC5943524__F8 Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2 SPHK2 SPHK1 PMC5745765__F7 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature IFNG TSLP TGFB1 HGF CD1A IL33 PMC5745765__F6 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature IFNG TSLP TGFB1 HGF CD1A IL33 PMC3321383__F2 Linking Lipids to Alzheimer’s Disease: Cholesterol and Beyond BACE1 APP PMC5745765__F5 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature IFNG TSLP TGFB1 HGF CD1A IL33 PMC5745765__F4 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature IFNG TSLP TGFB1 HGF CD1A IL33 PMC209479__F2 Inhibitory effects of SOCS-3 and SHP-1 on LIF-mediated gene expression STAT3 LIF PMC5369969__F14 HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo BAX BAD RAF1 ULK1 MCL1 MTOR TSC2 HDAC10 HDAC5 ATM HDAC11 HDAC2 HDAC6 PMC209479__F1 Corticotroph SOCS-3 as an intracellular suppressor of cytokine signaling STAT3 LIF POMC PAH PMC7760347__F2 Mechanisms governing bile acid (BA) enterohepatic circulation FGF8A GPBAR1 PYY FGFR4 PMC8285010__F1 Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARG in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol LPL UBC OLR1 NR1C1 CYP8B1 AQP7 CYP7A1 UCP1 HEL-S-28 PLTP ME1 PMC8285010__F2 Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARG in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol RPE LRAT DHRS4 CYP1A1 RETSAT CYP4A11 PMC5777317__F1 Regulation of the immune response by the aryl hydrocarbon receptor AIP AHR AHRR PMC8427239__F1 MicroRNA-9 as a paradoxical but critical regulator of cancer metastasis: Implications in personalized medicine CYP4Z1 STARD13 FOXO1 PTEN MYC DUSP14 PMC8427239__F3 MicroRNA-9 as a paradoxical but critical regulator of cancer metastasis: Implications in personalized medicine NRP1 RYBP YY1 VEGFA PMC5745765__F9 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature IFNG TSLP TGFB1 HGF CD1A IL33 PMC9399743__F1 Another level of complex-ity: The role of metabolic channeling and metabolons in plant terpenoid metabolism IPP CPO SMO ERG PMC8188681__F2 Review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma BAD CDK6 HIF1A MDM2 MYC CDK4 EIF4E PMC4065011__F5 Ablation of Coactivator Med1 Switches the Cell Fate of Dental Epithelia to That Generating Hair KRT1 KRT10 WNT3A S100A8 KRT16 TWIST2 IGFBP2 TGM1 SOX9 SHH PRELP FOXA1 IDE VWF JUN EGR1 VWA2 EMILIN2 FOS ANGPT4 CD44 ANGPTL4 MFAP4 CHST1 ANGPTL7 S100A9 PMC9941074__F2 Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19 TMPRSS2 IL19 TBK1 MAVS STAT2 IRF9 IRF3 IRF7 TRAF3 TRAF6 STAT1 NLRP3 TLR3 TLR8 HEL-S-11 TLR7 JAK1 TYK2 ACE2 PMC8188681__F1 Review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma ALK SOS1 EGFR FGFR1 GRB2 PMC4973584__F1 Lmx1b and miR135a2 in modulating the Wnt pathway and influencing midbrain size, mDA progenitor specification and neurogenesis LMX1B APC GSK3B WNT1 CCND1 PMC7431397__F2 GPCR-mediated proinflammatory signaling via signalosomes and endosomes MAP3K7IP1 BCL10 CYLD PMC3060239__F5 Model of the RBP-ROH/STRA6/JAK/STAT pathway SOCS3 PMC8341163__F3 Cas-induced nick processing and strand replacement LIG1 DNA2 FEN1 PCNA PARP1 PMC6701981__F1 Muscle Wasting Diseases: Novel Targets and Treatments STAT3 KLF15 GDF8 IGF1 SMAD2 BCAT2 TFEB IGF1R SOCS3 TNF GHR IRS1 PMC8341163__F4 CBE outcomes in gDNA REV1 LIG1 PCNA POLK POLE POLN CIT PMC9397555__F2 Involvement of phosphatidylserine receptors in the skeletal muscle regeneration: therapeutic implications MFGE8 AXL CD36 ARHA SRC PMC11008420__F1 MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma CDH2 EGF HGF EGFR PTEN ZEB2 GRB2 MTOR CCND1 PMC11008420__F2 MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma CDH2 CD44 TGFBR2 STAT3 SMAD2 APC SMAD4 ZEB2 CCND1 CTNNB1 PMC5665169__F3 RNA editing-dependent epitranscriptome diversity in cancer stem cells EIF4G1 HOXA9 NUMB MSI2 IKZF2 MYC PABPC1 TSPAN3 PMC7407942__F1 Schematic process of the autophagic pathway VPS11 EGFR ULK1 UVRAG ATG14 BNIP3 PTEN BNIP3L RHEB ATG10 TSC2 TSC1 ATG12 TFEB SESN3 VPS18 MDM2 ATG5 ULK2 PMC4754448__F1 Actin associated proteins regulate YAP activity LATS1 LPA LATS2 TEAD2 PATJ TEAD3 AMOT PTEN RHO NF2 TEAD4 CTNNB1 PMC4716054__F1 TrkB-mediated signaling pathways and possible therapeutic targets in cancer BAD GRB2 MTOR BDNF PMC7072634__F1 Ultra-structures, components, and functions of intermitochondrial cement (IMC) and mitochondria-associated ER membranes (MAMs) in male germ cells are summarized TES XRN1 GTSF1 TDRD1 HIG-1 MOV10L1 TDRD6 DAZL MAEL PMC3507180__F2 Hypothetic regulation of gene expression by HNF-4A by spherical cell shape in FLC-4 cells NCOR2 TNFAIP6 ALDH2 VEGFC FAS NR1C1 NR2A1 NR2F2 ADH6 MYC ABCC2 PMC2746202__F1 Pathway from PI3K to TOR RHEB TSC2 PTEN PMC5773178__F2 Signalling pathway impact analysis of gene expression data from H226 MM cells expressing C91A-mutant (mt BAP1) or wild-type BAP1 (wt BAP1) NGF BAD TRADD FES ATM TRAF2 FADD MYD88 PMC7405480__F3 The PI3K/AKT pathway by binding and ubiquitylation of tumor-regulating proteins in gastric cancer WWP1 SMURF1 PHLPP1 DAB2IP PTEN PMC7405480__F2 The p53 signaling pathway by binding and ubiquitylation of tumor-regulating proteins in GC RFWD2 MKRN1 MDM2 TRIM59 PMC9669386__F1 Ferroptosis in lymphoma: Emerging mechanisms and a novel therapeutic approach SLC3A2 STAT1 LOX ACSL3 STEAP3 GPX4 SCD LPCAT3 SLC7A11 ATF4 HEL-S-64p HEL-75 PMC7405480__F1 Important signaling pathways by E3 ubiquitin ligases in gastric cancer STAT3 RNF185 FBXW7 UBR5 RNF43 RNF38 RNF6 ARHA TRAF2 CTNNB1 PMC9121204__F1 Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management (Review) RIPK3 STAT3 BAX TRADD MLKL EPO MTOR NACA FADD PMC6721579__F4 Role of heat shock protein 27 (HSP27) in different cellular apoptotic processes BAX FADD PMC9548139__F1 Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study CYP21A2 STAR CYP17A1 CYP11B2 CYP11A1 SULT2A1 SULT1E1 HSD17B12 PMC11747284__F4 Schematic represents the PRLR signaling pathways, including both long and short isoforms PRLR FYN GRB2 IRS1 PMC6133069__F8 Schematic depiction of the results and proposed hypothesis ADRBK1 FYN NNT PMC8657749__F1 Phytosterols in Seaweeds: An Overview on Biosynthesis to Biomedical Applications IPP MOS MVP PMC7751007__F3 Notch signaling pathway CCND3 EGF MAML1 ECD HES1 PMC5019383__F3 DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions IL19 IFNE SYK EGF LTA TRADD TIRAP LAT RELB CD14 BLNK TRAF6 LTB CNTF NGF BCR COX2 TLR4 ATM LYN LBP TRIM23 PMC10374640__F5 Pharmacological mechanism of Beta-elemene in the treatment of esophageal cancer revealed by network pharmacology and experimental verification STAT3 HEL113 PCNA EGFR PTEN HIF1A MTOR CTNNB1 RB1 BIRC5 BCL2L1 CHEK2 MYCL CCND1 ABCB1 CDH2 BAX CASP9 IL10 PTGS2 MMP9 VEGFA IL6 TNF CDKN1A NFKB1 CDKN1B BCL2 PMC8583837__F3 Long Non-Coding RNAs in Endometriosis MMP2 MMP9 CREB1 PMC3436227__F2 MyD-88 dependent TLR signaling pathway TLR1 TLR4 TLR9 IRAK1 IRF3 TLR7 TRAF6 IRAK4 MYD88 PMC8900001__F2 Glycolysis in the progression of pancreatic cancer HEL-S-68p GEM HEL-S-162eP HEL-S-30 KRAS PMC4422156__F1 Schematic of TLR signaling and gene expression following stroke BAX TLR3 TLR4 IRF3 TLR7 MYD88 PMC8900001__F1 Glycolysis in the progression of pancreatic cancer UHRF2 GEM UQCRC2 KRAS PMC3358876__F1 H. pylori-induced miR-155 expression in macrophage immune cells TLR1 TSPAN14 TLR4 LPIN1 PMAIP1 MYD88 PMC6372777__F2 Figure describes the different effects of gut and brain serotonin on the osteoblast TPH1 HTR1B CCNE1 CCND2 APC GSK3B ATF4 CCND1 CTNNB1 PMC4422156__F2 Poly-IC postconditioning activates the TLR3/IRF3 signaling pathway and increases the IFNB levels and subsequently downregulates TLR/NFKB signaling to decrease the levels of pro-inflammatory cytokines TLR3 TLR4 IRF3 MYD88 PMC5624635__F1 MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response ATR ATM MDM2 PMC4904898__F2 PI3K/AKT pathway RHEB TSC2 RICTOR TSC1 PTEN MTOR PMC6000073__F1 LKB1及其下游相关靶点信号通路示意结构图Schematic illustration of LKB1 signaling pathway and related downstream targets for cancer therapy LOX COX2 MTOR PMC3250525__F3 Visualization of the quantity of genes differentially regulated by Gamma-tocotrienol (GT3) and Alpha-tocopherol (aTOC) using the KEGG cell cycle pathway SKA2 PCNA CDC6 SMAD2 SMAD4 MYT1 ORC3 SKP2 ORC2 E2F4 F2 CDK2 MDM2 PMC10757967__F3 Advances in the regulatory mechanisms of mTOR in necroptosis RIPK3 CASP8 TRADD MLKL RIPK1 MTOR TRAF2 FADD PMC10757967__F2 Advances in the regulatory mechanisms of mTOR in necroptosis FAS CASP8 TRADD MLKL OTULIN RIPK3 ZBP1 TLR3 TLR4 KL RIPK1 TRAF2 CYLD FADD PMC5547476__F9 Cartoon depicts the role of MYBL2 and FoxM1 in glioma progression CDH2 BAX FOXM1 MYBL2 MMP2 CDK2 PTEN CCND1 PMC10757967__F1 Advances in the regulatory mechanisms of mTOR in necroptosis RHEB ARF1 TTI1 CASTOR2 DEPTOR PMC8750056__F2 Genetic Mutations of Pancreatic Cancer and Genetically Engineered Mouse Models PI3 PTEN GRB2 PMC5306280__F1 Activation of the canonical NFKB pathway ZAP70 SYK PLCG1 TRAF6 TNF TRAF2 LCK PMC7250567__F6 Proposed model of K. pneumoniae-stimulated signaling pathway SYK SCAP2 SIRPA PMC2695202__F2 Emerging anti-inflammatory therapy SLPI CXCL1 CCR2 IL8RB CCL2 HDAC2 PMC7957534__F3 Role and regulation of CTHRC1 in canonical and noncanonical Wnt signaling APC ROR2 CTHRC1 ARHA DPAGT1 RAC1 DAAM1 CTNNB1 PMC7957534__F2 CTHRC1 modulating collagen deposition and vascular repair following injury through the TGFB signaling pathway SMAD2 CTHRC1 SMAD4 SMURF2 PMC9261164__F2 Pleiotropic effects of cell competition between normal and transformed cells in mammalian cancers HEL113 PDK4 EPHA2 S1PR2 RHO LILRB3 PMC6817417__F1 PI3K/Akt signaling pathway regulated by PTEN PTEN MDM2 MTOR PMC5157014__F3 Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice NCAN DNAH7 CNOT8 INA F2RL3 PAG1 TRIM50 ELP6 TTN CDCP2 ECT2L FEZF1 ZNF761 PMC484174__F8 A testable model for the modulating role of Dcs1 in the yeast stress response DCP2 MGP EIF4E PMC2692634__F1 THE ENZYMES OF THE 10-FORMYL-TETRAHYDROFOLATE SYNTHETIC PATHWAY ARE FOUND EXCLUSIVELY IN THE CYTOSOL OF THE TRYPANOSOMATID PARASITE LEISHMANIA MAJOR MTHFD2 MTHFD1 FTL PMC11658190__F2 Functions of the Ddx family in the development, differentiation, and homeostasis of oligodendrocytes DDX5 MBP DDX54 MDM2 PMC7868698__F2 Deep Look into the Program of Rapid Tumor Growth of Hepatocellular Carcinoma RB1 REN SMC1B SI ATM MYC ORC2 PMC9155226__F1 Trimming the fat: is there a health economic case for the use of new lipid-lowering drugs in chronic kidney disease? A scoping review LPL LPA ABCG1 LDLR PMC11658190__F4 Dual inhibition mechanism of the p53 pathway by Olig2 GEMIN2 GEMIN5 GEMIN6 OLIG2 GEMIN7 GEMIN8 MDM2 PMC10610144__F7 SBP effects on BMP2-Smad1/5/9-Runx2 signaling pathway SMAD9 SMAD1 DKFZp781O1323 BMP2 SPARC RUNX2 PMC9178561__F6 First study on the effect of crocodile oil from Crocodylus siamensis on hepatic mitochondrial function for energy homeostasis in rats ACLY RPTOR RICTOR EIF4EBP1 RPS6KB1 CFTR MTOR HDHD3 PMC2897911__F1 Induction of Type I Interferons by Bacteria TLR3 TLR4 TLR9 TLR8 TLR7 MYD88 PMC6337367__F1 Kinases in the insulin signaling cascades and its interaction with nutrients in control of FOXO1-mediated physiological function HMOX1 OGT PTEN AgRP IRS1 PMC9513079__F2 Interaction between LSC and BMM CD44 CXCL12 MSC MTOR CXCR4 PMC6429987__F2 AMPK-mTOR signaling pathways during Mtb infection ULK1 IRGM TFEB NOD2 MTOR PMC6429987__F1 Brief summary of reciprocal regulation between AMPK and mTOR pathways RHEB TSC2 TSC1 MTOR PMC7349502__F2 N-glycan trimming of the HBV envelope glycoproteins EDEM3 EDEM1 SEL1L EDEM2 PMC7434793__F1 Resistance to BRAF-targeted therapy EGF EGFR BRAF MTOR KIAA1549 PMC7232129__F7 HBV-miR-3 activation of innate immunity to restrain HBV replication STAT1 IFNAR1 IFIT3 IFIT2 MX1 OAS1 PMC4590661__F3 Regulation of autophagy by the MTORC1 signaling pathway in cancer cells RRAGB RRAGD GLS ULK1 SQSTM1 SLC7A5 ATG101 GLUD1 TSC2 TSC1 PIG59 TFEB RB1CC1 ATM RRAGA PMC5716985__F1 Mechanism of epithelial-to-mesenchymal transition (EMT) CDH2 EGF HGF FOXC2 CTNNB1 PMC8319800__F3 Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models HMGB1 DCX NLRP3 TNF PMC8491217__F2 Lipid metabolism in cancer progression and therapeutic strategies LATS1 ACLY PGC LATS2 FASN PMC5834531__F6 This figure summarizes the central s-resistin downregulation effects on hypothalamic and peripheral insulin and leptin sensitivity STAT3 POMC NPY IRS1 PMC9062983__F1 Effect of Fluoride on Cytotoxicity Involved in Mitochondrial Dysfunction: A Review of Mechanism BAX SDHA CAD NLRP3 BCL2 PMC8232269__F4 One Hundred Candidate Genes and Their Roles in Drought and Salt Tolerance in Wheat TF LOX PC PMC7105613__F1 Tryptophan catabolic pathway HEL-S-90n IDO1 KYNU HAAO IDO2 PMC8789279__F7 Schematics for the BNP-NPRC facilitated signaling pathway and distinct neuropeptide pathways for histamine-dependent and -independent itch GRPR ITCH NMBR NMB PMC7246682__F6 Action of fractalkine on JEG-3 trophoblast cells Fractalkine binds to its cognate receptor on the surface of trophoblast cells activating MAPK and AKT pathways CX3CR1 SMAD2 CX3CL1 BMP2 MMP2 MMP9 PMC6029864__F1 Notch signaling on T cells MAML1 APC CTLA4 PMC11535288__F7 Overall metabolic pathways altered in systemic (plasma) and lung tissue of OVA-induced asthma mice after BS012 administration TG LOX PC PMC7905103__F5 Diagram depicting a potential mechanism of interactions BPI TLR4 CD14 LBP PMC11722561__F1 Recent Updates and Advances in the Association Between Vitamin D Deficiency and Risk of Thrombotic Disease CRP VIT TF IL6 TNF PMC8137704__F4 Whole transcriptome RNA-seq reveals key regulatory factors involved in type 2 diabetes pathology in peripheral fat of Asian Indians MAPK1 MYOD1 NR0B2 MAPK3 HDAC3 MAPK14 SUMO1 PPARGC1B NR2A1 HIPK2 TP63 NFE2L2 CSNK2A1 CDK2 PPARGC1A FOXA2 CDK4 PMC2859933__F9 Evidence for Alteration of Gene Regulatory Networks through MicroRNAs of the HIV-Infected Brain: Novel Analysis of Retrospective Cases ENSA CSF2RA tmp_locus_29 FOXP2 HEL-S-11 PMC6948367__F3 Alternative STING pathway activation MAP3K7IP1 IRF1 ATM IRF3 IL6 TRAF6 PMC11879837__F10 Illustration of the JAK2/STAT3 and PI3K/AKT signaling pathways implicated in the protective effect of SM on kidneys injured by DN STAT3 BAX MTOR TNF PMC6948367__F2 Canonical STING pathway activation TBK1 CGAS IFI16 IRF3 CCL4 IL6 CXCL10 PMC4121105__F1 KEAP1/CUL3/RBX1 E3-ligase protein complex RBX1 KEAP1 PMC6948367__F1 Homologous recombination repair pathway (adapted from De Picciotto et al.) BRIP1 RAD52 ATR RAD50 RAD51 H2AX BRCA2 MDC1 MRE11A BRCA1 RNF8 ATM PALB2 PMC3298518__F2 Pathogenesis of neurodegenerative diseases is significantly associated with oxidative stress KEAP1 NQO1 MAF PMC3973444__F7 Alterations in the levels of vesicular trafficking proteins involved in HIV replication in the brains and CSF of patients with HIV-associated neurocognitive disorders CHMP5 CHMP6 TSG101 CHMP2A ISG15 PMC6885354__F4 Analysis of miRNA expression profiles in the liver of Clock-delta19 mutant mice GATA2 RAF1 SUV39H2 NR1D1 MYF5 HIF1A PLK4 MAPK9 GPR55 NFIL3 MAPK3 EPHB2 ADRA1B SNAI1 IQGAP3 CENPK CRY2 NRAS NOTCH1 GRPR ATAD2 TAOK1 SP1 TNF TCF3 RICTOR FZD4 PAFAH1B1 MAP3K1 CDKN1A PLCB1 AXIN1 ADCY1 BAK1 ARID4A MYO5B TUBGCP5 QRFPR FZD5 DUSP10 MAK16 PPM1D HTR4 RPS6KA2 MED26 AKT3 CBX4 FBXW11 PPP2CA PRKCH RBBP7 PER3 LPAR4 CCND2 FKBP1A APP RGS1 YWHAG IKZF1 ETS2 YES1 SGK1 PER2 PER1 RGMB RAC1 SFRP1 MEF2D CBL RHOB BMP2 EP300 CALCA LEF1 PPP2R5A PPARG SMG1 MYBL2 FBL ZWINT SETD2 CHD9 MAP3K2 MAP2K6 ETV6 RALA CARM1 SP3 TUBB4A PDS5B ACVR2A BATF ADM ROCK2 GNB2 BAP1 TBPL1 BHLHB2 FOS SMARCA5 RAP2C ATF3 RAD21 FOXO1 GADD45A SIRT1 STAG2 CXCL9 HGF IMP3 HMMR PAK4 IQGAP1 PTEN CASR CDK19 BTRC MAP2K4 INSR NR1D2 DYNC1H1 RND1 MED13 CRYZ DDX5 JUN RHOBTB3 FZD7 SMAD6 PTPN1 NFATC1 EPHA4 GATA3 S1PR3 RGS18 ITSN2 SH3PXD2B CACNB4 SUCNR1 MAP2K1 PRKG1 KAT2B PMC3574816__F1 Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention APC GSK3B CTNNB1 PMC7403467__F1 Quantification of CpG Motifs in rAAV Genomes: Avoiding the Toll IFNG IL10 PDC TLR9 IL4 MYD88 PMC5148003__F1 AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells TGFBR2 ACTA2 COL1A1 SMAD2 MMP2 LEF1 TGFBR1 PMC5082787__F10 Schematic illustration of Ro inhibiting autophagic flux and sensitizing chemoresistant esophageal cancer cells to 5-Fu-induced cell death NR3A2 CHEK1 NCF1 CYBB PMC9166453__F2 Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases CDC42 BAX ATF2 RHO MTOR PMC5864191__F2 Mevalonate pathway and mutp53 MVP PMVK MVD FDPS RHO MVK PMC3583581__F2 Recent advances in prostate development and links to prostatic diseases SHH MMP2 BMP7 SMO SFRP1 PMC8616517__F3 Kinase Inhibitors’ Effects on Innate Immunity in Solid Cancers APC PMC8900217__F2 DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling CCL22 CGAS APC PMC3146975__F3 Coordinate Regulation of mRNA Decay Networks by GU-rich Elements and CELF1 CDC42 GNAI3 GNAI1 IKZF1 IKZF4 KCNC2 ADRA2A PLEC TP63 MT1E GALR3 SRGAP3 ATF1 FPR2 CXCR4 PMC8900217__F1 DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling TBK1 CGAS IRF3 PMC5864191__F4 Functional association between mutp53 and mevalonate pathway-associated oncogenic proteins (Ras, RhoA, YAP/TAZ) EGFR ARHA PMC3146975__F1 Coordinate Regulation of mRNA Decay Networks by GU-rich Elements and CELF1 SYK CSF1 FYN SHB SHOC2 LAT JUNB CREM GRB2 SRC PMC9357935__F2 Research Progress of Myocardial Fibrosis and Atrial Fibrillation TLR4 TNF MYD88 PMC10387486__F4 Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets BTBD7 PIEZO1 SMAD1 TGFB1 DKFZp781O1323 SMAD2 SUN1 SMAD4 HEL-S-28 ARHA PMC9281132__F2 Wnt signaling in colorectal cancer: pathogenic role and therapeutic target RSPO4 ZNF3 RNF43 DKK1 APC LRP6 CTNNB1 PMC11578537__F7 Iron-dependent hepatic regulation of hepcidin STAT3 TFR2 HAMP HFE HFE2 PMC3583581__F4 Recent advances in prostate development and links to prostatic diseases FOXA1 SHH PTEN PMC4172644__F1 Geographical and ethnic distribution of single nucleotide polymorphisms within genes of the folate/homocysteine pathway metabolism VIT MTHFD1 FOLH1 TCN2 MTRR HEL-S-61p SLC19A1 MTR PMC1601945__F1 Model of RNF11 interactions in the TGFB receptor signaling pathway RNF11 SMAD4 SMURF2 PMC2685981__F1 Gene Expression Profiling of Lymphoblasts from Autistic and Nonaffected Sib Pairs: Altered Pathways in Neuronal Development and Steroid Biosynthesis SVIL LEP CD36 ASPSCR1 PDE4DIP SDC4 PRKCZ INS COL24A1 HSPD1 LITAF BCL7A CD9 TLR4 PC NFKBIZ GOT2 ATP2B2 SP1 IL13 IL4 IFI16 IL1A FAP TNF SCN5A LMO4 SCARB1 RELA WASF2 CXCR4 PMC5979336__F10 Scheme of possible signaling pathways involved in regulating the functional state of Cx43 HCs, Panx1 Chs, P2X7Rs and Cx GJs in mesangial cells stimulated with AngII PANX1 ARHA IL1B PMC12188374__F2 (1) Treatment with EGFR-TKI or KRAS inhibitors may lead to AST STAT3 CXCL5 KRT6A CXCL3 PMC12188374__F1 (1) The EML4-ALK fusion protein produced by ALK rearrangement can activate the JAK-STAT signaling pathway FOXA1 STAT3 TET2 VEZF1 CXCL5 SOX2 MYC KRAS CXCL3 FOXM1 ALK NKX2-1 FOXA2 ZEB2 ELF5 PMC7166227__F3 Different mechanisms are triggered when stimulated by the different nucleotides in the CeCa TME EGFR UMPS PMC2685981__F3 Gene Expression Profiling of Lymphoblasts from Autistic and Nonaffected Sib Pairs: Altered Pathways in Neuronal Development and Steroid Biosynthesis IL15 PPARG TGFA TGFB1 HGF PTEN CSF3 MAPK14 HSPD1 CD9 POMC SHH SRC NFKBIZ IL1B CD81 IL13 IL4 IL5 TNLG2B GATA3 ENG SCARB1 CXCR4 BCL6 PF4 PMC5228603__F3 Reparative inflammation takes charge of tissue regeneration LATS1 ROR1 STAT3 LATS2 WNT3A APC ROR2 LRP5 LRP6 IL11 RHO CTNNB1 PMC4357208__F1 Metabolic network for flux analysis TK1 MAL CIT PMC5829655__F1 Hypothetical model summarizing the probable mechanisms of severe inflammation in malaria TRAF3 IL1B GATA3 MYD88 PMC1526546__F1 Innate model of lupus pathogenesis: central role of TLR-activated MZ-B cells and pDCs CD40 PDC TLR9 PMC4196647__F2 E-cadherin on RTK signalling STAT1 ERBB4 EGFR MDM2 PMC6336458__F1 Molecular mechanisms of viral oncogenesis in humans CD40 FOXM1 MAML1 BCR TLR4 APC IRAK1 ADAM10 TRAF6 PMC3887674__F1 Factors influencing the reprogramming of unipotent SSCs into pluripotent stem cells GDNF SOX2 TAF4B NANOS2 PMC8866866__F1 Nerve Dependence in Colorectal Cancer CDH2 MMP7 NGF GDNF COX2 EGFR MMP9 BDNF PMC8517930__F7 Novel insights into the regulation of LATS2 kinase in prehierarchical follicle development via the Hippo pathway in hen ovary LATS2 STAR TEAD3 NR3A2 STK4 FSHR PMC3788359__F3 Pathways linking hypoxia to CSCs and EMT in tumor aggressiveness SOX2 BNIP3 ZEB2 IGF2 PMC7059351__F2 Alteration of synthesis and degradation pathways of glycosphingolipids in the physiopathology of HSP B4GALNT1 GBA2 PMC6805914__F7 EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells EPHB4 EIF2A SRC MYC PMC4476649__F1 Regulation of Lymphocyte Function by Adenosine IL4 FOXP3 CD1D PMC4088370__F3 KEGG Cell-cycle pathway RAD21 CDK7 PCNA MYT1 SKP2 PMC6627635__F3 Predicted/established targets of selective flavonoids in platelets: Flavonoids modulate platelet activation through multiple mechanisms SYK FYN COX1 LAT PMC4088370__F2 KEGG MAPK signalling pathway ECSIT NGF FAS NF1 CD14 HRG PMC11280061__F6 Auxin-regulated TFRN attenuates lignin biosynthesis IRX4 CCR2 CAMTA1 PMC9204003__F2 Long Noncoding RNA and Circular RNA: Two Rising Stars in Regulating Epithelial-Mesenchymal Transition of Pancreatic Cancer FOXD1 EGFR SOX2 EZH2 SOCS3 ARHA TUG1 TGFBR1 TGFBR2 STAT1 DYNC2H1 NLRP3 HOXA13 NT5E FGFR1 SOCS5 PMC11280061__F7 Auxin-regulated TFRN attenuates ABA transport, conjugation and signaling FER GPX3 ABI3 CAMTA1 PMC3415708__F5 Novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer SDHD MCAT PCK2 GCDH ECHS1 FH ACO2 OGDH HEL-S-133P ACADVL HEL-S-87p PMC3415708__F4 A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer SDHD OGDH APP MAOA PMC4088370__F4 KEGG Apoptosis pathway NGF TRADD TRAF2 FADD PMC7063119__F1 Apelin/APJ system–mediated signaling pathways KLF2 HDAC5 PMC12208858__F2 Intravascular release and mechanism of pH-responsive TwHF nanocarrier STAT3 ICAM2 VCAM1 TNF PMC3568227__F2 Role of mesothelin in cancer progressionOverexpression of mesothelin leads to higher IL-6 production by constitutively activating NFKB STAT3 BAX BAD MSLN CDK2 PMC3088358__F7 The extracellular network of proteins that control D–V patterning BMP4 BMP2 BMP7 PMC305326__F1 The development, activation, and maintenance of the satellite cell HGF IGF1 MYF5 PAX7 PMC4273559__F2 KEGG pathways significantly associated with NPG EHHADH CACNG5 HHIP GADD45G BDH1 SOS1 EVI1 MAPKAPK3 RAC3 WNT10A MEF2C FYN PRKCA WNT4 ECHS1 CACNA1C CD14 BMP7 CACNG4 ALDH3A2 HMGCS1 XYLT1 EXT2 WNT8B PLA2G4B PMC3554567__F4 Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left–Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry FOXH1 SMAD4 NODAL PMC5423040__F2 Hunger-satiety circuit and energy balance GHSR PYY INSR LEPR POMC MC4R NPY ARC AgRP PMC8906956__F8 Postconditioning with Irisin Attenuates Lung Ischemia/Reperfusion Injury by Suppressing Ferroptosis via Induction of the Nrf2/HO-1 Signal Axis SLC3A2 GPX4 SLC7A11 PMC4273559__F3 Butanonate metabolic pathway (KEGG pathway hsa00650) ACSM2B EHHADH ACSM4 HMGCL BDH1 GAD1 AACS BDH2 ABAT ACAT1 ALDH2 OXCT2 GAD2 OXCT1 ECHS1 ACADS ACSM2A ACSM5 ALDH3A2 HMGCS1 PDHA1 ALDH5A1 ACSM3 ACAT2 ALDH7A1 L2HGDH ALDH9A1 PDHA2 PMC4929427__F2 Cross-talk of mammalian Hippo signalling with the MAPK, PI3K and intrinsic and extrinsic apoptotic pathways CDC2 BAX ATR EGR1 RAF1 PML RUNX2 KRAS CTNNB1 ARAF WBP2 AMOT BCL2 ATM MDM2 AIFM1 PMC5954090__F7 The metabolic characteristics of a low-carnitine zebrafish model LPL INSR MTOR PMC8804323__F1 FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling CYP8B1 CYP7A1 HSD3B7 CYP7B1 CYP27A1 PMC7242447__F3 Genetic variation and evolutionary history of a mycorrhizal fungus regulate the currency of exchange in symbiosis with the food security crop cassava LPA PDHA1 DLAT GPD2 RAD1 PC DLD CS PMC4061845__F2 Sphingolipid involvement in ethanol-induced apoptosis in the P7 mouse brain S1PR1 BAX SPHK2 GSK3B PMC7326156__F7 Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E RPS6 MTOR EIF4E PMC9178120__F5 Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors PHGDH SLC7A11 VCP PMC2413330__F3 Working hypothesis on the mechanism by which plasminogen activator inhibitor-1 (PAI-1) causes hepatic steatosis HGF MTTP TNF PMC9178120__F4 Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors SLC38A1 RAE1 GLS2 PMC9178120__F2 Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors SLAMF7 IL10 HGF CCR5 DKK1 IGF1R IL6 VCAM1 CXCR4 CCR8 CCR1 PMC8920443__F37 2022 WHO Classification of Adrenal Cortical Tumors KCNJ5 ATP2B3 CACNA1H MC2R ATP1A1 PMC11005288__F5 Compound Shenma Jingfu granule alleviates cerebral ischemia via HIF-1Alpha-mediated promotion of angiogenesis TF RPS6 MAFK TFRC HEL-S-133P TLR4 HEL-S-162eP EPO MTOR HEL-S-87p DAO VHL PMC8721229__F4 Differential Effects of Propylthiouracil and Methimazole as Graves’ Disease Treatment on Vascular Atherosclerosis Markers: A Randomized Clinical Trial PTEN VCAM1 PMC4371960__F6 E2-induced signal transduction pathways in the uterine epithelium leading to DNA and protein synthesis RPS6 IGF1 GSK3B IGF1R MTOR PMC5877395__F1 Annexin A2 (ANXA2) in cancer progression CDH2 S100A10 ANXA2 SOX2 PLG MIEN1 PMC8533518__F1 Enhancement of Beta-Alanine Biosynthesis in Escherichia coli Based on Multivariate Modular Metabolic Engineering MAL ASPA CIT PMC6006330__F8 BMP2/4 increase neurogenesis from adult hippocampal NSPCs and synergize with WNT3A BMPR1A BMP4 BMP2 LEF1 PMC5622154__F2 Differentially expressed genes upon congenital neonatal human cytomegalovirus (HCMV) infection form distinct subnetworks GRINA GYPE NKG7 RUNDC3A R3HDM4 IFIT3 TNS1 GBP4 GBP5 GC20 STAT1 GZMH BCL2L1 GUK1 ATP6V0C HEL-S-11 UBXN6 HEL-S-134P RBM38 GYPB DPM2 RNF10 ADIPOR1 ERAF GBP1 RSAD2 ALAS2 CDC34 OSBP2 SLC4A1 PRF1 EPB42 FBXO7 TRIM58 HAGH GMPR ST6GALNAC4 MYL4 PMC12222446__F1 Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias SLC3A2 GPC1 GLS MTAP SMS SMOX PAOX ARG1 AMD1 PIG59 SRM PRODH ARG2 PMC3395153__F1 Roles of Platelets and the Signal Transductions Identified as the Major Cascades in Hepatocyte Proliferation STAT3 HGF TGFA IGF1 IL6 MTOR PMC5661633__F2 NFKB in the regulation of NLRP3 inflammasome MAP3K7IP1 NLRP3 TRAF6 IL1B MYD88 PMC9647118__F2 Homologous recombination BARD1 RAD51 BRCA2 PALB2 PMC12222446__F5 Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias AMD1 MTAP SMS SRM SMOX PAOX ARG1 ARG2 PMC4673348__F5 Proposed schematic showing targets of SA transcriptional regulation of insulin signaling pathway INSR PRKCZ MTOR GCK PMC9368916__F3 Comparative Transcriptome Analysis Reveals Coordinated Transcriptional Regulation of Central and Secondary Metabolism in the Trichomes of Cannabis Cultivars IPP LOX MVD GAS1 PMC6913448__F1 Structures of CLEC-2 and podoplanin SYK BTK LAT SRC PMC4134368__F2 Biosynthesis of spiruchostatins C2 AMT SPIB PMC2844056__F7 Genes involved in cell-cell signaling significantly associated with ERbreast cancer cells in response to AA CARD8 CST5 BAX NLRP1 CASP9 BAD AVEN COL11A2 SRPX TNF CASP10 PMC2844056__F6 Insulin receptor cascade was uniquely up regulated in ER− cells when treated with AA LTA SMAD4 IL4 VEGFA IRF4 KHDRBS1 NR3C1 CSF3R LTB TRAF4 LOX NTF3 NR3A2 VPREB1 SPIB HAS2 RCAN1 PMC2844056__F5 Ingenuity pathway analysis of genes up regulated in ER+ cell in response to AA shows that the ERK/MEK pathway was significantly associated with ER+ STAT3 BAD TRIM2 PMC2844056__F2 Ingenuity pathway analysis and expression profiles of genes involved in apoptosis that were uniquely up regulated in ER+ cells in response to EPA STAT1 RAD21 PAWR RPL36 PHIP PMC4052811__F2 Deduced pathway of sterol biosynthesis in N IPP DHCR24 SMO PMC3114846__F5 Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases ABCB5 ASIP HOXD12 HOXA9 KLRB1 KLRK1 DCT STX17 PMC11674819__F2 PD-1/PD-L1 signaling pathway CD80 APC PMC8591899__F1 SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities TMPRSS2 IL-21 IFNG MAVS IL4 IL2 IL6 CXCL10 CCL2 ACE2 PMC11576170__F3 The ICE1-CBF-COR signaling cascade BIN2 PIF1 ICE1 PMC8591899__F5 SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities KEAP1 MAF PMC11576170__F2 Perception and transduction of cold signals in plants CBL ICE1 COG3 PMC6857111__F11 Huaier inhibited breast cancer progression through linc00339/miR-4656/CSNK2B signaling pathway CSNK2B PMC11576170__F4 ROS homeostasis regulates plant cold tolerance MYB TCP1 ENO2 PMC9016203__F5 Therapeutic Applications of Physalins: Powerful Natural Weapons STAT3 SUFU APC GSK3B LRP5 LRP6 SMO CTNNB1 PMC9025601__F3 Epigenome-Wide Analysis of DNA Methylation in Parkinson’s Disease Cortex TP73 CYP2E1 TNF CP PMC8518235__F8 Endometrial regenerative cells with galectin-9 high-expression attenuate experimental autoimmune hepatitis GAL LAT LCK PMC8245853__F2 CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment PDPN CXCL9 CD80 CXCL12 FAS CSF1 VEGFA CXCL10 CHI3L1 HDAC1 STAT1 HLA-E HLA-G COX2 SHH CXCR4 LAG3 HDAC6 PMC6680919__F4 Leptin signaling STAT3 POMC TPO AgRP PMC2978002__F7 Model demonstrating the specific apoptotic effect of SREBP-1 and FAS inhibition on GBM cells bearing EGFRvIII FAS EGFR PTEN MTOR PMC11004450__F6 Single cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells OGA OGT GNPNAT1 PGM3 NAGK PMC9601999__F4 Genes Related to Cognition after tDCS in an Intermittent Hypoxic Brain Injury Rat Model CDC42 BAX CRK NGF SHB FRS2 RHOD SHE RAC1 PMC5302168__F8 Transcriptional regulation of SPROUTY 2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 SPRY2 RPS6 RASA2 GRB2 MTOR PMC6279925__F4 Network visualization of top primary hits STXBP4 DOT1L TCIRG1 NTS GPHN MPG CTPS2 WASF3 TACR2 IL27 PIK3C2G FHL2 SLC25A4 MAPK14 XCR1 CAMKK2 FZD3 PIWIL2 SMO SH3GL3 NUDT12 ROR2 VEGFA CDC34 BHLHB2 GRAP ADCY3 PTCH2 OGDH MCM5 FAAP24 IGFBP7 Meflin PIGM GCNT1 BLMH TRPC7 NR1C2 IGFBP6 CRTC1 SUMO1 UGT2A1 GDF15 NR1D2 TOB2 NFKBIE CAMK4 KCNJ2 CLK2 HEL-S-30 DIO1 IL2RB RAD1 MAFF MOBP FGF20 SNX2 SELP PMC2685661__F10 NO/cGMP and calcium signaling in osteoblast mechanotransduction FOSB TAP1 PMC9175095__F8 Exosomal CTCF Confers Cisplatin Resistance in Osteosarcoma by Promoting Autophagy via the IGF2-AS/miR-579-3p/MSH6 Axis MSH6 CTCF PMC5649483__F1 Showing a putative Th17/Treg/Th1/Th2 regulatory axis IL13 FOXP3 GATA3 PMC8921682__F3 Decline in Liver Mitochondria Metabolic Function Is Restored by Hochuekkito Through Sirtuin 1 in Aged Mice With Malnutrition CRAT CYP7A1 CHDH PMC5436301__F1 DNA repair pathways in mammalian cells ERCC1 XPA RAD52 ATR RAD51 BRCA2 RIF1 SSB PARP1 XPC DNA2 BRCA1 ATM POLE PMC5436301__F2 Interstrand crosslinks can be repaired by replication-independent (left) and replication-dependent (right) mechanisms ATR REV1 BRCA1 POLK FANCM FAAP24 SLX4 PMC11004450__F1 Single cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells OGA OGT GNPNAT1 PGM3 NAGK PMC5436301__F6 Repression of or mutation in several upstream regulators of homologous recombination (HR) can be synthetically lethal with PARP1 inhibition because they can cause a variety of HR repair defects that prevent fork restart RAD51 MRE11A H2AX WRN USP11 PTEN POLE BLM PARP1 PMC7260582__F1 Action of cetuximab, encorafenib and binimetinib STAT3 EGF HGF EGFR MTOR PMC12004712__F10 KEGG “Leukocyte transendothelial migration” pathwayKEGG “Leukocyte transendothelial migration” pathway highlighting the associated AC contrast DEGs CDC42 ARHH VASP ITGA4 THY1 ARHA JAM3 RAC1 CD99 TEC JAM2 ITGAM ITGB1 CXCR4 PROC PMC10526380__F3 Molecular Classifiers in Skin Cancers: Challenges and Promises SUFU PTCH1 MTOR MYC PMC11992302__F2 Six signaling pathways associated with the PD-L1 and PD-1 pathways in melanoma PTEN MTOR GLI3 PMC8154588__F5 Synthetic lethal interactions in SWI/SNF-mutant cancers with chemical tools for targeted cancer therapy ATR UBE2C EZH2 MDM4 CDK6 ARID1B GCLC MDM2 SRC SS18 HDAC6 SMARCA4 PS1TP5BP1 CDK4 PMC3848582__F5 Schematic model demonstrating functional involvement of NPM1, RAD50 and XRCC5 in DSB-repair in the progression of ovarian cancer cells CDC2 XRCC5 RAD50 MRE11A NPM1 ATM CCND1 PMC150381__F2 Interplay of the major genetic alteration in pancreatic carcinoma with the cell cycle CDK6 SMAD4 CCND1 CDK4 PMC2672935__F2 Regulated molecules in canonical signalling pathways identified by IPA TAPBP IL10 SFN PTEN ARHA RHO SKP2 HEL-S-99n STAT1 CDKN1A CDC37 TRAF2 FADD PMC6766639__F4 Impact of IT on mitochondrion-related gene expression and on selected mitochondrial outcomes in tissues collected from UCD-T2DM rats at 1.5 mo-post surgery PGS1 PGP CDS2 CDS1 PTPMT1 CRLS1 CS PMC4553756__F3 Delta-1-pyrroline-5-carboxylate synthase (P5CS) pathway ASL ALDH18A1 OTC ARG1 PMC12130906__F2 Regulatory functions of the TGFB/Smad signaling pathway in the renal fibrosis CTCF SMAD2 SMAD4 TNF PMC7582884__F1 PI3K/Akt signal pathway, p53 signal pathway, and mTOR signal pathway in NPC MDK EGF SMG1 EGFR UBQLN1 PTEN SQSTM1 MTOR FGF2 COL1A1 FOXO1 MYH9 CDKN3 MDM2 RBM3 CCND1 PMC11934714__F5 HERV in the pathogenesis of ALS TBK1 CGAS IRF3 IRF7 PMC11934714__F4 HERV in schizophrenia SLC3A2 CGAS DRD2 GPX4 IRF3 BDNF TRPC3 DISC1 DRD3 PMC11934714__F2 The roles of retrotransposons in adult neurogenesis HDAC1 YTHDC1 SOX11 TET1 SOX2 NTRK3 TUT7 NAT1 CTNNB1 PMC5856294__F3 GPCR signaling and the organization of the stem cells niche STAT3 RNF43 EGFR APC ZNRF3 PTH PMC4872111__F1 Genes involved in CRC pathway DVL1 BAX CASP9 DCC BAD MSH2 APPL1 SMAD2 APC GSK3B SMAD4 RHO TGFBR1 CTNNB1 FZD3 SOS2 CASP3 BCL2 DVL3 PMC9509228__F2 Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy GABARAP BNIP3 FUNDC1 MTOR EIF2A TRAF2 PMC7854732__F10 Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer TMPRSS2 SPOP ERG PMC8001237__F1 An overview of various approaches used in myostatin inhibition GDF8 SMAD2 PMC9609640__F7 SmMYB4 Is a R2R3-MYB Transcriptional Repressor Regulating the Biosynthesis of Phenolic Acids and Tanshinones in Salvia miltiorrhiza MYB IPP PMC6925860__F8 The schematic diagram depicts the mechanism of CPP-induced enhancement of sensitivity to TRAIL in ESCC cells FOXP3 CTNNB1 FADD PMC4326572__F1 Main molecular pathways activated in the presence or absence of nutrients RHEB ULK1 AMBRA1 PMC4872111__F6 Downstream effects of miR-145 ectopic expression MAX CDC42 RAF1 SMAD4 ATF2 CDKN2B CDK6 CCNE1 MAP2K6 CDKN1A PAK1 CDKN1B CHUK CDK2 GRB2 MAP2K3 CCND1 CDK4 PMC5356793__F4 Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma HPD ACVR2B FSTL3 HES6 ACTL6B KIF20A STX19 CLDN16 STX8 PLEKHB1 SCAMP5 CLDN19 SYCE3 SYCE1 HOOK1 TESC CLUAP1 RAI1 SLC30A5 ACVR1 PI4KB CINP NAA38 ZBTB7C PMC7333179__F1 Proposed estradiol-induced hypothalamic astrocyte steroidogenesis of neuroP that activates a membrane classical progesterone receptor (PGR)-Src tyrosine kinase (Src) signaling pathway in RP3V kisspeptin neurons to trigger the luteinizing (LH) surge KISS1 STAR PGR PBR KISS1R SRC PMC4407676__F2 The two representative networks by ingenuity pathway analysis (IPA) for differentially methylated whole gene set derived from HF-dNK-treated EVT VAV2 PMC5462754__F6 Ingenuity Pathway Analysis showing a network biology system for the interaction between both the miRNAs and the metabolites identified from the metabonomic analysis SYN2 GRIA2 ADRA1D CREM ADRB3 RB1 CBL HMGCR INSR ARHGEF12 APP ADRB1 STX3A PMC3533466__F1 Genes whose mRNA expression is suppressed by nicotine in RAW264.7 cells under poly(I:C) stimulation compared with those under poly(I:C) stimulation only are mapped to three gene networks, as predicted by ingenuity pathway analysis (IPA) IFNG TIRAP IRF7 IL6 LBP FADD PMC3155176__F4 FRAM Is Characterized by Increased Signaling of the BRAF/MEK/ERK Pathway(A) IPA analysis led to the generation of a gene-interaction network of genes differentially expressed in patients SELE TMEFF2 BRAF RASSF4 ENTPD1 DUSP2 DAAM1 PMC8909695__F2 Organic UV Filters Induce Toll-like-Receptors and Related Signaling Pathways in Peripheral Blood Mononuclear Cells of Juvenile Loggerhead Sea Turtles (Caretta caretta) TLR1 LPO AKT3 RAC1 SET PMC11973847__F3 PRR signaling pathways associated with autoinflammatory diseases NLRC4 CGAS MAVS NLRP3 RIPK1 IRF3 PMC7640965__F1 SARS-CoV-2 infection and proliferation process mediated by host and viral proteases TMPRSS2 PLG TMPRSS4 FURIN ACE2 PMC10137236__F1 TGFB signaling pathway SMAD2 SMAD4 TGFBR1 PMC12025273__F6 Mechanism map of cerebral ischemia in JU JUN UBC SUMO2 ITGA4 ELAVL1 GRB2 NRF1 YWHAZ PMC2803288__F4 Schematic diagram depicting the pathway via which GC-A signaling inhibits cardiac hypertrophy GC RGS4 GCA PMC3533466__F5 Nicotine’s effect on multiple signal transducers in the downstream pathway of calcium DAG1 SHC1 PAK1 EGFR VAV1 ATF2 GRB2 MTOR SRC MYC RAC1 GAB2 PMC5016702__F8 The signaling pathway by which FSH, via PKA, regulates the PI3K and ERK pathways in GCs IGF1 EGFR IRS1 PMC5130074__F1 Scheme depicting the possible mechanism of VEGFR-2-mediated vascular effects (cell proliferation, survival, migration, and enhanced permeability) related to vascular formation CDC42 BAD SHB SRC PMC5867880__F3 CD99wt and CD99sh in tumor cells ROCK2 MMP9 CD99 PMC4925727__F3 Tyrosine kinase receptors and their signalling pathways involved in angiogenesis BAD EGFR PTEN GRB2 MTOR SRC CTNNB1 PMC4427058__F7 The identified epigenetic regulatory mechanism involved in the miR-124/STAT3 pathway in pediatric-UC STAT3 BCL2 MMP9 PMC8288060__F7 Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated DKK1 APC CTNNB1 PMC4052206__F6 Ingenuity pathway analysis (IPA) displaying regulatory relationships among highly expressed (green) and lower (red) placental transcripts in less muscular women as compared with women with high arm muscle area LST1 CD40 IFNG ICOS MHC2TA C1QA PSMB8 SP100 HLA-DRB1 RELA IRF1 C1QB PMC11790818__F3 Notch signaling pathway MYC FURIN PMC4292729__F1 Molecular and cellular mechanisms of immunogenic cell death IFNG HEL-S-92n IL1B PMC9626530__F3 Therapeutic potential of triptolide and celastrol in neurological diseases HMGB1 NLRP3 BACE1 IL33 MTOR TNF PMC9626530__F2 Therapeutic potential of triptolide and celastrol in neurological diseases NGF BACE1 IL8RB MTOR BDNF PMC6535773__F6 Dimensionality and the cell malignancy potential on lipid species amounts in the MCF10A breast cancer in vitro model TG SMS tmp_locus_29 PC KDSR PMC9161693__F1 Astrocytic Calcium and cAMP in Neurodegenerative Diseases tmp_locus_29 MCU ADA PMC7914425__F5 NOD-like receptor-signaling pathway constructed based on full-length sequencing and annotation results of the skin transcriptome of a sperm whale MAVS NOD2 IRF3 IRF7 PMC5593685__F1 The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy HEL-S-133P LDHB VEGFA PMC6824681__F10 The SGK3 signaling pathway STX6 STX12 STX7 STX8 VTI1B VAMP8 VAMP4 PMC7595665__F3 m6A modulators involved in cardiovascular disease and bioprocess XPO6 HGF HNRNPD TFEB CALM1 PMC5495885__F3 MiRNA discovery NR1i1 CDC42 SMAD6 IRF7 NODAL RUNX2 SKI PITX2 AMN FOXH1 SMURF1 TLX2 GSC GRB2 PMC8268320__F3 TGFB Pathway: A Pharmacological Target in Hepatocellular Carcinoma? IL15 CTLA4 PMC9682260__F4 Alteration of cholesterol distribution at the plasma membrane of cancer cells: From evidence to pathophysiological implication and promising therapy strategy HRAS CD44 APC FADD PMC8268320__F2 TGFB Pathway: A Pharmacological Target in Hepatocellular Carcinoma? CCL7 CXCL16 MICA CCL5 MTOR CCL2 PMC12063356__F5 Combined Ibr + AS treatment modulates both upstream and downstream effectors of the BCR (A, B) PI3K-AKT signaling pathways SYK CD81 BAD CD22 RBL2 BLNK PTEN CD19 BLK RHEB TSC2 BTK BCL10 BCR GC RAE1 NPB LYN GRB2 PROC PMC3974512__F1 Hepatitis C virus entry into hepatocytes HRAS APOC1 EPHA2 SHC1 NPC1L1 EGFR APOE LDLR RHO GRB2 CLDN1 PMC8268320__F1 TGFB Pathway: A Pharmacological Target in Hepatocellular Carcinoma? TF EGFR SMAD2 SMAD4 RHO FURIN NOX4 CTNNB1 PMC7682108__F1 Intracellular cholesterol homeostasis ABCG1 ABCG8 ABCG5 HMGCR LDLR ABCA1 PMC9394213__F2 Roles and functions of SARS-CoV-2 proteins in host immune evasion TBK1 MAVS STAT2 IRF9 IRF3 IRF7 JAK1 TYK2 PMC9394213__F3 Roles and functions of SARS-CoV-2 proteins in host immune evasion STAT1 MAVS STAT2 IRF9 IRF3 NUP98 PMC5354945__F2 Therapeutic small-molecules target inhibitor of apoptosis proteins in cancers with deregulation of extrinsic and intrinsic cell death pathways CD40 TRADD MLKL RELA RELB CASP3 TRAF3 TRAF2 FADD PMC3917351__F4 Ca2+ transport remodelling in tumour vascularization TRPM7 TRPM2 TRPV2 TRPC4 TRPC6 TRPM6 TRPC3 PMC3917351__F3 Ca2+ transport remodelling in the promotion of cancer cell metastasis S100A4 TRPM7 TRPV2 TRPV1 TRPV6 TRPM8 PMC3917351__F2 Ca2+ transport remodelling in conferring apoptosis resistance in cancer cells ORAI1 STIM1 TRPC4 TRPC1 TRPV1 TRPV6 PMC3917351__F1 Ca2+ transport remodelling in promotion of cancer cell proliferation ORAI3 TRPM7 TRPM2 ORAI1 STIM1 TRPC6 TRPC3 TRPV6 TRPM8 PMC5813531__F3 Retrograde signaling during photooxidative stress in chloroplasts PC MAPK6 MAPK3 PMC4115292__F1 The one carbon (methyl group) metabolism in vivo HEL-S-182mP PMC3627223__F1 The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway SYK BCR NFKB2 PMC4590954__F5 Non-Smad signaling in response to TGFB1 and BMP-7 CDH2 BMP7 GRB2 MTOR TRAF6 CTNNB1 PMC2912210__F1 Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response NF1 EGFR GRB2 MYC FOS PMC5571864__F1 Daily Rhythm in Plasma N-Acetyltryptamine NAT2 TPH1 AANAT TPH2 ASMT DDC NAT1 PMC7767853__F4 Interactions between picornavirus 2C protein and the NFKB and retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) pathways MAVS NOD2 IRF3 PMC6211389__F3 Type I interferon (IFN) gene induction by IFN regulatory factors (IRFs) on innate recognition of cytosolic nucleic acids TBK1 CGAS MAVS DDX41 IFI16 IRF3 IRF7 IRF8 PMC6211389__F2 Schematic view of Toll-like receptor (TLR)-mediated type I interferon (IFN) gene induction by IFN regulatory factors (IRFs) TBK1 TIRAP TLR9 IRAK1 IRF1 IRF3 IRF7 TRAF3 IRF8 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR7 PMC6581447__F2 Construction of the signaling network of cell migration regulators and their classification based on biological functions CDC42 ABI2 HEL113 ABL2 AKT3 PAK4 IGF1R RHO ITGAV LAIR1 ARHGAP26 FRMD6 ADD1 ALK ITGB8 tmp_locus_29 PTS TPM3 GFRA2 CSNK1A1 DGKZ IRGM APC TRIP10 NRP2 GNAL IRF4 CDH12 ARHGAP5 CORO1B PMC3980263__F3 The LNG1 data set EGF PIK3R3 EGFR CYCS GSK3B SMAD4 CDKN2B NR0B2 SKP2 GNAS DRD2 FBXW2 PORCN E2F3 CHUK SENP2 ADCY6 ABCG2 SRC FHIT CACYBP BIRC3 CASP9 NOS2 LRP6 ARHA TUBB KRAS CXXC4 HMGCR MAPK7 NFKBIA CREBBP BCL2 NLK GRB2 PMC8898366__F9 PrPC Promotes Endometriosis Progression by Reprogramming Cholesterol Metabolism and Estrogen Biosynthesis of Endometrial Stromal Cells through PPARA Pathway NR1C1 HMGCR ABCA1 PMC3248195__F1 Elevated PI3K signaling drives multiple Breast Cancer subtypes TSC2 BAD TSC1 INPP4B IGFBP1 PTEN IGF1R IRS1 PMC4757520__F2 Signaling pathway alterations in Kupffer cells after alcohol and/or burn injury TLR4 CD14 TNF LBP IRAK4 PMC9526616__F7 Early Development of Cardiac Fibrosis in Young Old-Father Offspring WT1 TBX18 TCF21 PMC4526690__F3 Comparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation RPL5 RPL11 MDM2 PMC4017424__F1 NFKB signaling pathways TNF FADD PMC3896749__F9 Hypothesis for the development of tactile allodynia following nerve injury TIRAP TLR4 IRF3 TNF MYD88 PMC8490010__F3 From APC to the genetics of hereditary and familial colon cancer syndromes ACVR2B ACVR2A STK11 MSH2 PMS2 PCNA BMPR1A APC CTNNB1 OGG1 MLH3 RNF43 ACVR1 MUTYH ZNRF3 NTHL1 GPR49 PMC8221416__F3 TLR signalling pathway TLR1 TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 IRF7 TLR7 MYD88 PMC8221416__F2 NLR signalling pathway NLRP1 JUN NOD2 NOD1 IL1B PMC4017424__F4 Activation of IKK pathway PTEN GRB2 MTOR SRC PMC5302996__F1 LncRNAs in pancreatic cancer AURKA CDK6 HMGA2 NUF2 GDF15 SOX2 CCND1 CDK4 WDR5 PMC10473144__F3 Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer’s Disease APC GSK3B LRP5 LRP6 PMC10473144__F2 Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer’s Disease DKK1 APC GSK3B LRP5 LRP6 CTNNB1 PMC8883733__F2 Mucor circinelloides: a model organism for oleaginous fungi and its potential applications in bioactive lipid production IPP MAL HEL-S-5 CIT PMC6240607__F4 Schematic depiction of GDNF/RET/GFRA1 signaling in the ureteric bud (UB) tip during kidney development ETV5 GDNF ETV4 SPRY1 RET PMC9455009__F1 Programmed Necrosis in Colorectal Cancer TRADD GPX4 GZMA TNF TRAF2 FADD PMC11870059__F8 Metabolic pathway reconstruction graphs of the starch, nitrogen, and lipid in the rumen of sheep fed different forage and grain sources H1-5 HIST1H1E H1-1 H1-0 H1-3 H1-2 PMC4271074__F8 OAA effects and inter-effect relationships DCX CCL11 MTOR NRF1 PMC10452754__F2 The molecular interaction between HLA-G and decidual NK cells at the maternal–fetal interface KIR2DL4 PTN COX2 HLA-G PBX1 PDK2 PMC6830889__F1 Main TLR-mediated signaling pathways triggered upon stimulation by LPS and LPG SYK TIRAP IRF3 MTOR TRAF3 TRAF6 MYD88 TLR1 RAB8A NLRP3 TLR4 LBP IL1B PMC8932105__F7 Tumor-associated macrophage derived IL-6 enriches cancer stem cell population and promotes breast tumor progression via Stat-3 pathway STAT3 SOX2 PMC9179504__F1 Small Extracellular Vesicles: Key Forces Mediating the Development and Metastasis of Colorectal Cancer STAT3 CXCL13 GMDS PTEN CXCR4 KRAS S100A9 PMC6527583__F4 Acute phase response network: The acute phase response was the most-significantly represented pathway common to all CAPN5-NIV stages TF C1S AMBP C1R HEL111 ORM1 HRG RBP4 HEL-S-78p C4A INF2 APOH F2 C9 FGA IL6ST C4B_2 PMC5711380__F7 Schematic summary of the IL-1B–IL-1 receptor signaling cascades identified in decidualizing human ESCs IL16 NFKB1 RELB MTOR PMC9489753__F2 Liver Regeneration in Chronic Liver Injuries: Basic and Clinical Applications Focusing on Macrophages and Natural Killer Cells STAT3 WNT3A CX3CR1 CX3CL1 CCR2 VEGFA CCL2 IL1B PMC9489753__F1 Liver Regeneration in Chronic Liver Injuries: Basic and Clinical Applications Focusing on Macrophages and Natural Killer Cells FGF7 HGF LTBR FGF9 PMC7695717__F6 Oxytocin signalling network enriched in the analysis of the interaction of diet and n-3 PUFA supplementation in pregnant heifers OXT ARHH COMP OMP COX2 ELL DAO PMC4269339__F2 Signal transducer and activator of transcription 3 (STAT3) pathways involved in immune escape IFNG STAT3 STAT1 EGF EGFR TAP1 TAP2 PMC6016836__F3 Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection CDC42 EGFR CRKL GNG12 GNAL HBEGF PRKCI ACTR3 PAK1 PFN3 GRB2 SRC ITGAE PMC3272142__F4 Signaling pathways promoting trophoblast invasion and migration GSK3B RHO MTOR CTNNB1 PMC5794834__F1 Complement amplification loop C6 C7 CFD C9 PMC7069124__F4 Overlaying the consensus TLR4 signaling pathway in databases with HemeKG (A: original overlaid network, B: overlaid network after inclusion of literature evidence for effectors) CD40 CXCL9 CD80 TIRAP TAB3 IRAK1 IRAK2 MAP2 TRAF3 MAPK8 TRAF6 CXCL8 IRAK4 IKBKG MYD88 MAP2K4 TLR4 IRAK3 MAP6 CHUK MAP2K3 IL1B MAPK1 INPP5D CD14 IRF3 IRF7 IL6 TNF CXCL10 CXCL11 MAP3K7IP1 IKBKB NFKBIA MAP2K1 PMC7069124__F3 Consensus around the TLR4 signaling pathway in three major pathway databases MAPK4 TIRAP TLR4 CHUK MAP2K3 PMC5842404__F4 AMP‐dependent protein kinase (AMPK) signalling pathway LPO INA EP300 PMC5842404__F3 B cell receptor (BCR) signalling pathway BLK SYK ITGAM BTK BCL10 AFP ASAP2 SP100 BLNK LYN DAO PMC8145847__F3 Hepatitis C Virus Uses Host Lipids to Its Own Advantage CD81 LDLR CLDN1 PMC8308767__F4 Phytomedicines Targeting Cancer Stem Cells: Therapeutic Opportunities and Prospects for Pharmaceutical Development RB1 SHH SMO CTNNB1 PMC9165556__F1 Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB Signaling Transcription and Upregulation of Alternative Inflammatory Transcripts in Pediatric Inflammatory Bowel Disease PYCARD ATG16L1 ITCH MAPK8 MAPK14 RIPK2 NLRP3 IL18 NOD2 BIRC2 CARD9 IMPACT IL1B BIRC3 PMC3509712__F1 Signal transduction pathways used by superantigens and mediators ZAP70 LAT IRF9 IRF1 MTOR RHO TNF TRAF6 HEL-S-11 GRB2 JAK1 LCK FADD PMC7961492__F1 Mechanisms and molecules involved in cholesterol metabolism and homeostasis and the regulatory effects of Non-encoding RNAs are depicted in a foam cell APOC2 LPL ACAT2 CDKN2B PMC9683098__F6 ECM-associated protein secretion and intracellular accumulation in dermal fibroblasts C7 SMAD2 PMC4177547__F1 PI3K/Akt/mTOR pathway and relative inhibitors in NHL RHEB TSC2 RICTOR TSC1 PTEN MTOR PMC3403008__F3 Regulation of TLS in replication-associated ICL repair RAD18 REV1 PCNA FAN1 PMC6584837__F1 PI3K/AKT and cell cycle signaling pathway model of NKTCL RICTOR FOXO3A PIK3AP1 PTEN MTOR CCND1 PMC6527025__F7 Apoptosis Signalling in T-Helper Cells During HIV Infection.HIV proteins are involved in apoptosis BAX FAS BCL2 CXCR4 APAF1 PMC6527025__F6 UPR Signaling During Influenza A Virus Infection.Upon IAV infection, BiP is released from UPR proteins (e.g EDEM1 EDEM2 ATF4 EIF2A XBP1 PMC4546216__F5 Scheme of the phenylpropanoid pathway FH CAD CCR1 PMC6527025__F5 Apoptosis Signaling During Influenza A Virus Infection.IAV infection affects apoptosis in early and late infection BAX BAD RNF43 CLU IL1B HDAC6 PMC3528279__F3 RIG-I/MAVS signaling pathway regulating hMPV-induced NFKB and IRF activation in airway epithelial cells TBK1 MAVS TANK IRF3 PMC3528279__F2 Toll-Like Receptors (TLR) signaling pathway involved in hMPV-induced gene expression in primary immune cells TBK1 TIRAP ID2 CD14 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR4 RELA TLR7 PMC7885587__F6 Pathway analysis EGF TGFB1 PGR LIMK1 EGFR IGF1R AKR1C1 MTOR VEGFA NCOA1 MYC TGFBR2 RHEB IGF1 NR3A2 ID4 ERBB2 WNT1 MAP3K7 WNT4 SRC MAP2K3 PMC6527025__F2 Apoptosis Signaling During Arbovirus Infection.Arboviruses exert their effect on apoptosis through different signaling routes BAD TRADD EIF2A HRK FADD PMC6527025__F1 The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections MAVS ATG12 IRF3 ATG5 PMC3542934__F1 TGFB signalling pathway TGFBR2 FBN1 SMAD2 SMAD4 ARHA TGFBR1 PMC8927915__F1 Teaching cancer imaging in the era of precision medicine: Looking at the big picture EGF EGFR APC PMC6764500__F3 Significant metabolic pathways, Ubiquitin‐mediated proteolysis pathway and Adherens junction and Wnt signaling pathway for regulated genes associated with IS‐SM when compared to IS‐NSM SLC33A1 GCNT4 TERF2 GLS BRCA1 MID1 C1GALT1C1 AOC2 DAO LEF1 CCNC ADSL PMC4826512__F3 Targeting of the Wnt/Beta-catenin signaling pathway by Tat altered miRNAs MMP7 HDAC1 DKK1 HEL-S-28 TCF4 MDM2 NLK SRC PIN1 CTNNB1 PMC6689752__F1 Regulatory effects of micro-RNAs (miR) on specific stages of neuronal development PTBP1 LIMK1 PUM2 PMC4826512__F4 Targeting of the axonal guidance signaling by Tat altered miRNA CDCA2 CRK FARP2 FYN PXN RHOD FES CXCR4 RND1 SDC2 EIF4E PMC2679127__F2 PRRs and their corresponding ligands TLR1 TLR3 TLR9 NOD2 TLR5 TLR7 TRAF6 TLR10 MYD88 PMC7193471__F8 Signaling model of the IL6R-ADAR1-STAT3 interplay in multiple myeloma STAT3 MCL1 BCL2 IL6 IL6R PMC9153132__F2 Intratumor microbiome in cancer progression: current developments, challenges and future trends TIGIT AHR FAP CTNNB1 PMC5357760__F2 Epidermal growth factor receptor (EGFR)–related signaling pathway in metastatic colorectal cancer PIK3CA EGFR MTOR PMC9424811__F2 RING finger protein family in health and disease RNF41 RNF128 RNF121 RNF31 TLR9 IRF3 TRAF3 TRAF6 RNF170 MYD88 TLR3 RNF115 TLR4 RNF19A RNF114 RNF182 TLR7 RNF152 RNF166 PMC9548363__F8 Juniperus communis extract ameliorates lipopolysaccharide‐induced acute kidney injury through the adenosine monophosphate–activated protein kinase pathway TLR4 CCL2 IL1B PMC9424811__F4 RING finger protein family in health and disease RNF128 RNF185 TBK1 CGAS RNF115 RNF5 RNF114 IRF3 RNF26 RNF111 PMC7262792__F3 Possible mechanisms for growth hormone (GH) deficiency in children with mosaic gain-of-function mutations in the PI3K-AKT-MTOR pathway: IGF1 GHRH IGF1R MTOR PMC9424811__F3 RING finger protein family in health and disease RNF128 RNF121 TBK1 RNF122 MAVS RNF5 RNF123 RNF11 IRF3 TRAF3 RNF125 RNF115 RNF34 RNF114 RIPK1 RNF19B PMC8757826__F2 Oral Cancer Stem Cells: Therapeutic Implications and Challenges BMI1 CD44 EGF CD24 HEL-S-53e EGFR SMAD2 PTCH1 SOX2 SMO CTNNB1 PMC9424811__F5 RING finger protein family in health and disease STAT2 IRF9 RNF31 IFIT3 RNF213 RNF2 STAT1 RNF115 IFNAR2 RNF168 IFNAR1 ISG15 JAK1 RNF19B TYK2 RNF220 PMC5579609__F3 PC-DHA levels depend on nutrition, liver and brain synthesis by PEMT and transport of LPC-DHA across the blood-brain barrier catalyzed by MFSD2A FAS PEMT HEL-S-61p MTR PMC5974170__F3 Lipid droplets and the immune response during protozoan infection ICE2 GC IRGM PMC5090835__F1 Anesthesia-induced pathways of neuronal apoptosis.Anesthesia induces apoptosis by seven different pathways FAS BDNF PMC2948618__F3 3rd US-EU Workshop Systems level understanding of DNA damage responses ATR ATM CDC25B PMC2832236__F5 BS and M chloroplast distribution of proteins involved in primary carbon metabolism RPE PGP HEL-S-62p HEL-S-68p PGM2 GIP PMC7215321__F3 Necroptotic signaling pathway exemplified by tumor necrosis factor alpha (TNFA)-mediated activation of tumor necrosis factor receptor (TNFR)1 RIPK3 TRADD MLKL RIPK1 CYLD FADD PMC6142519__F3 Aberrations in the Ras signaling pathway that lead to excessive proliferation CBL NF1 GRB2 GAB2 PMC2830120__F3 Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection STAT3 FYN PMC5501852__F6 Interaction network of cancer cells and their microenvironment associated with the EMT process LTBP1 PARD6A FUS STAT3 SMAD2 GSK3B PTPRF SMAD4 SERPINB5 INHBA SNAI1 WAS SHH SMO SRC DCN RUNX1T1 TNF TM4SF4 ARHGAP5 CRK CRB3 PTCH1 SMURF2 TWIST1 PTPRM CDC42 EGF HGF TGFA TGFB1 EGFR THBS2 MTOR CTNNB1 TLR4 CAV2 JUN PDGFA SMAD6 KIT BMP7 ARHA KRAS IGF2 KITLG SFRP1 ERBB2 BMPER PMC3862457__F1 Signaling pathways that modulate amino acid, insulin/IGF-I, and resistance exercise–induced activation of mTORC1 signaling RHEB MLST8 TSC2 TSC1 WDR59 NPRL2 TBC1D7 DEPDC5 SEH1L MIOS WDR24 PMC7463266__F9 Illustration of this study’s results and a working model SMAD1 DKFZp781O1323 ATOH8 RUNX2 PMC9460414__F1 Plant-Derived (Poly)phenols and Their Metabolic Outcomes: The Pursuit of a Role for the Gut Microbiota DBP MBP INS PMC7377092__F1 ERK signaling ERCC1 EGF ATR WEE1 BNIP3 ATM CCND1 PMC8374228__F3 Lymphadenopathy at the crossroad between immunodeficiency and autoinflammation: An intriguing challenge STAT3 CD80 FAS BACH2 BCR STAT5B APC LRBA FOXP3 FADD PMC11937136__F6 Proposed mechanism for reproductive damage induced by ICIs through testicular inflammation, oxidative stress, and ferroptosis, as well as the protective role of RSV against ICIs-induced reproductive toxicity SLC3A2 KEAP1 COX2 GPX4 NQO1 FACL4 SLC7A11 PMC12140338__S1 Potential mechanism by which viridicatol (VDC), derived from deep‐sea fungus, enhances osteoblastogenesis through modulation of the Wnt/SHN3 signaling pathway BGLAP ALPL APC GSK3B SP7 IBSP RUNX2 CTNNB1 PMC4314728__F9 Schematic of the signaling pathways activated by the P2Y2R in endothelial cells that are thought to regulate vascular permeability GAA VAV2 RAC1 PMC4405894__F3 Pathway of all possible EGFR family dimer combinations showing various growth factors known to activate EGFR family and all possible dimer combinations ERBB3 STAT3 EGF TGFA ERBB4 EGFR ERBB2 MTOR SRC PMC5295437__F8 Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K/Akt/mTOR signaling pathway RHEB TSC2 TSC1 PMC5594916__F6 Schematic illustration shows targeting of the hnRNPA1/pri-miRNA-18*/K-RAS pathway by miR-25-3p and miR-15a-5p DGCR8 DROSHA PMC4270387__F1 Examples of non-stress-related peroxide signaling LPA EGF LOX STAR CYP11A1 PRX HIF1A CS PMC10669195__F1 Unleashing the Potential of Nrf2: A Novel Therapeutic Target for Pulmonary Vascular Remodeling RBX1 KEAP1 CDH6 RXRA MAF PMC6682991__F1 Representation of the various selenium metabolic pathways leading to selenoprotein synthesis SELENOF SELENOI GPX4 SELENOK SELENOM GPX3 SEPHS2 GPX1 SELENON SELENOT GPX6 GPX2 DIO1 SELENOH SELENOO SELS SELENOV TXNRD3 TXNRD2 SELENOP SELENOW PMC2879321__F1 Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis EGR1 KY EGFR GRB2 SRC MYD88 PMC11945442__F11 Proposed mechanism by which ACA affects the TNF-Alpha-induced NFKB pathway and ICAM-1 expression TRADD RIPK1 TRAF2 PMC6494926__F1 Granulin biogenesis, quality control at the ribosome during its synthesis, and molecular mechanism of FTLD associated with mutations in the signal peptide of the granulin precursor GRN PSAP M6PR PMC6533287__F5 Human mTOR pathway SGK1 PTEN MTOR RHO INS DEPTOR IRS1 EIF4E RHEB TSC2 RICTOR TSC1 GRB10 TBC1D7 GRB2 PMC8568331__F2 Targeting cyclin-dependent kinase 4/6 as a therapeutic approach for mucosal melanoma HRAS RB1 RASA2 NF1 EGFR BRAF NRAS KIT PTEN MAP3K11 CCND1 CTNNB1 PMC1781062__F1 CCM2 as a Scaffold for p38 MAPK Activation MAP2K4 MAP2K6 MAPKAPK2 MAPKAPK5 MAP2K3 PMC6104565__F5 Pharmacological targets of ErbB2 signaling pathway in Her2-enriched subtype EGF JUN BAD NRG3 MTOR SHE MYC NRG4 NRG2 CRK HBEGF CBL BTC GRB2 PMC4786834__F1 Linkage between the mechanisms of thrombocytopenia and thrombopoiesis MPL FLI1 KLF1 TPO PMC4122595__F2 AB oligomers activate several ‘stress-response’ kinase pathways in neurons TSC2 TSC1 CAMKK2 MTOR IAPP PMC2784807__F5 Ingenuity Pathway Analysis® network depicting relationships among genes involved in immune and metabolic responses due to IMI with Streptococcus uberis LPL GPAM CD36 SCD PLAUR CD14 LPIN1 HEL110 FOS SELP HEL-S-44 PMC10728021__F5 Proposed combination treatment strategy to tackle p53‐mutant esophageal squamous cell carcinoma (ESCC) tumors with a WEE1 inhibitor CDC2 ATR WEE1 ATM PMC2784807__F3 Cyclin-dependent kinase (CDK) 5 (A) and Insulin-like growth factor (IGF)-1 signaling pathways (B) among 2,102 differentially expressed genes due to intramammary infection with Streptococcus uberis NGF ATR IGF1 PAK1 PIGL APP IGF1R LPP PMC2784807__F1 IL-10 and IL-6 signaling pathways among 2,102 DEG due to IMI with Streptococcus uberis TH STAT3 FAS SHE CP PMC9376115__F5 Regulated cell death (RCD) in cancer: key pathways and targeted therapies NLRC4 NLRP1 GSDMD NLRP3 GSDMC GSDMB AIM2 PMC3260452__F2 Simplified model of the leptin signaling pathway TRH MC4R MC3R PC NPY AgRP BDNF PMC9376115__F6 Regulated cell death (RCD) in cancer: key pathways and targeted therapies POR ATF3 LOX KEAP1 GPX4 LPCAT3 BAP1 FACL4 PMC4251064__F2 Dataset was analyzed with the IPA software (Ingenuity Systems®, www.ingeuity.com) TP73 HDAC1 SIN3A TP63 PMC4251064__F4 Canonical pathway of TP53 signaling: dataset was analyzed with the IPA software (Ingenuity Systems®, www.ingeuity.com) GML MDM4 TOPBP1 ATR FAS PERP PML SDK2 PTEN TIGAR MDM2 PMC12195631__F8 Regulatory mechanism of BB in the treatment of CAG CDH2 MTOR PMC9376115__F3 Regulated cell death (RCD) in cancer: key pathways and targeted therapies ATG101 ATG3 PINK1 ULK1 AMBRA1 ATG14 CTNNB1 PMC9376115__F2 Regulated cell death (RCD) in cancer: key pathways and targeted therapies STAT3 BAX FAS TRADD TRAF2 FADD PMC11275360__F6 Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation FOXO3A MTOR PMC5674931__F5 The role of metabolism and microRNA (miRNA) in daunorubicin and cytarabine treatment CYP3A4 PMC11275360__F5 Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation RUNX1 MOS SRC PMC5674931__F4 The interactions between microRNAs (miRNAs) and cell death-related proteins in drug resistant cells FAS BCL2 BAK1 ATG5 PMC11275360__F4 lncRNA regulates adipocyte differentiation through TGFB/BMPs/Smad signaling pathway GDF11 BMP4 BMP7 PMC11275360__F3 Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation APC DVL3 CTNNB1 PMC6929101__F3 TGFB activation in the tumor microenvironment CXCL12 MSC IL11 PMC6929101__F2 TGFB alteration in colorectal cancer (CRC) cells IFNG VEGFC CXCL1 RHO IL8RB VEGFA CTNNB1 PMC10483926__F7 Illustration of a hypothetical model in which TgESPs regulate aerobic glycolysis to promote osteogenic differentiation through the Wnt/Beta-catenin signaling pathway HEL-S-133P HK2 LRP5 LRP6 RUNX2 LEF1 CTNNB1 PMC6929101__F1 Schematic representation of Transforming growth factor-beta (TGFB) superfamily signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD4 RHO PMC5345933__F2A Cell cycle proteins as promising targets in cancer therapy C6 DHFR SMAD4 CCNA2 MYC CTNNB1 GSK3A FOXO1 FOXO3A F3 CDK2 ATM CDK4 PMC4429713__F1 Radioactive 125I seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway ATR EED ATM PMC8068500__F2 Bioengineering strategies to control epithelial-to-mesenchymal transition for studies of cardiac development and disease WT1 CTNNB1 PMC8079716__F2 From purines to purinergic signalling: molecular functions and human diseases PAICS HEL-S-70p PMC4258159__F5 The PI3K/mTOR signaling pathway upon stimulation with growth factors, with an emphasis on the phosphoregulation of PRAS40 RHEB TSC2 EIF4B TSC1 MTOR DEPTOR IRS1 EIF4E PMC5961053__F1 Production, elimination, and signaling of ROS PRX HEL-S-44 PMC9489683__F5 Maintaining the regulatory T cell program during inflammation: a delicate balance USP44 TET2 ICOS TIGIT ID2 IL33 TET3 EZH2 FOXP3 NFIL3 IL1B STUB1 PMC9489683__F3 Treg suppression of conventional T cells STAT3 CD80 TIGIT FAS HPGD APC NRP1 FGL2 AHR LAG3 PMC9028246__F4 Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer LATS1 MOB1A TNKS EGFR AMOT RHO SRC PMC4357373__F11 Identification of microRNAs and their target genes in Alport syndrome using deep sequencing of iPSCs samples TES OMP ADA PMC9028246__F2 Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer LATS1 MOB1A FRMD6 TAOK1 AMOT WWC1 FAT1 AJUBA RHO NF2 SRC PMC9028246__F1 Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer LATS1 MOB1A PMC11632667__F3 1) BMPs activates the SMAD pathway, which increases inflammatory cytokines VEGF, tumor necrosis factor alpha (TNFA), and Interleukin-6 (IL-6) SMAD1 DKFZp781O1323 SMAD6 MSC SMAD4 PMC7661081__F1 MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 PMC3901996__F2 Transmembrane signaling of IL-6, which is a major growth factor for MM STAT3 STAT1 SOS1 GRB2 PMC8175905__F5 Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma MTOR CTNNB1 PMC3287579__F1 Adapted from PC RAC1 PMC9010499__F2 Intratumoral cancer immunotherapy exploiting anti-viral immunity TBK1 CGAS TLR3 TLR9 IRF3 IRF7 TLR7 MYD88 PMC3730324__F1 HIFs are involved in crucial aspects of tumor progression and metastasis in sarcomas IGF2 ABCB1 VHL PMC9641156__F3 Novel insight into the functions of N6-methyladenosine modified lncRNAs in cancers (Review) GC PC YTHDF1 METTL3 PMC11955304__F5 STAT3 signaling pathway can be targeted using various therapeutic agents STAT3 CPA1 SRC PMC11955304__F3 STAT3 Signaling Pathway in Health and Disease STAT3 IL11 SOCS3 IL6 SRC PMC5529905__F1 Signaling pathway resulting in TNFAlpha-mediated necroptosis, and specific necroptotic inhibitors targeting RIP1 and MLKL TRADD MLKL TRAF2 FADD PMC9028270__F2 Regulatory Processes of the Canonical Wnt/Beta-Catenin Pathway and Photobiomodulation in Diabetic Wound Repair APC GSK3B CTNNB1 PMC5670164__F2 Non-canonical activation of the sonic hedgehog (Shh) pathway SUFU SHH SMO PTEN PMC4341198__F8 Responses of Solid Tumor Cells in DMEM to Reactive Oxygen Species Generated by Non-Thermal Plasma and Chemically Induced ROS Systems BAX H2AX PMC5670164__F1 Sonic hedgehog (Shh) signaling pathway in a mammalian system KIF3A HHIP DHH SHH IHH SMO PMC4041829__F1 Overview of cellular Na+ transport mechanisms and important components of the salt stress response network in plant root cells MYB ERF SOS2 PMC4247580__F10 Arabidopsis Lipins, PDAT1 Acyltransferase, and SDP1 Triacylglycerol Lipase Synergistically Direct Fatty Acids toward Beta-Oxidation, Thereby Maintaining Membrane Lipid Homeostasis LPL FAS PC PMC8662819__F1 Single-Cell RNA Sequencing Reveals Multiple Pathways and the Tumor Microenvironment Could Lead to Chemotherapy Resistance in Cervical Cancer PDCD1 LAG3 PMC5670164__F3 Regulation of thyroid cancer stem cell (CSC) self-renewal by the sonic hedgehog (Shh) pathway BMI1 KLF4 CSF1 LIN28A SHH SMO MTOR PMC5822876__F6 Rheumatoid Arthritis-related molecular signaling pathway ATF2 CCL5 PMC3355898__F2 Somatic alterations in the PI3K pathway in prostate cancer PIK3CA INPP4B PIK3R3 PIK3R1 PTEN PMC6476484__F1 Biological functions of IL-32 in inflammatory tumors CCL21 MMP2 CXCL2 MMP9 PMC7769460__F6 The MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer MAX TH CDC20 INSIG1 CD164 CDK19 EPCAM ADAM17 CCBE1 OMP CENPK OR2B2 TLR4 OR7E24 KNSTRN TFDP2 BMPR2 LAMC2 SCD PLAUR KNTC2 KIT AREG HMGCS1 CD44 CRK HBEGF PEAR1 BIK PMC8467271__F3 Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery TBR1 TRAF4 USP15 USP4 SMAD4 SMURF2 USP9X OTUD1 HEL-117 PMC1773546__F3 The key proinflammatory pathway induced by enteric pathogens results in nuclear factor kappa B (NFKB) mediated transcription of interleukin 8 (IL-8) ARF6 TLR5 TRAF6 TRAF2 MYD88 PMC7794175__F1 Genomic alterations in the cyclin pathway in patients with cancer RB1 CCND3 CDKN2A CDK6 CDKN2C CDKN1A CCND2 CDKN1B CDKN2B CCND1 CDK4 PMC3627353__F2 Genes and signaling pathways involved in ureteric budding ROBO2 SALL1 SLIT2 GDNF SIX1 FOXC2 PAX2 BMP4 FOXC1 RET EYA1 GATA3 PMC8582360__F2 HGF/MET Signaling in Metastatic Uveal Melanoma STAT3 HGF GRB2 MTOR SRC RAC1 PMC6533683__F10 Regulating EMT by targeting autophagy HMGB1 HEL-S-28 CTNNB1 PMC2681266__F1 NFKB activation in cancer LTB EGFR RELA PMC6656421__F8 IPA Network RAB5B HSD3B2 CYP17A1 LHB INSR CYP11A1 KIAA1608 GATA6 INS LHCGR PMC4493903__F1 LIF is a new p53 negative regulator STAT3 LIF MDM2 ID1 PMC6640532__F1 Ubiquitin/26S proteasome system (UPS) RBX1 RPN2 SKP1 PMC7504089__F7 Differential gene expression in apoptosis and death receptor signaling pathway in ‘ECACC vs HTRA2 BAD TRADD TNFRSF1A CYCS GAS2 IKBKG ERN1 NGF MAP2K4 RIPK1 CHUK APP CRADD APAF1 BIRC3 BAX JUN CASP2 FOSB TNFSF6 TNF DFFB FOS ARHGDIB IKBKB DFFA BCL2 TNFSF10 BIRC2 TWEAK CASP10 TRAF2 NFKBIB DIABLO FADD PMC3499997__F2 Main therapeutic targets along the BCR signaling pathway in CLL cells SYK PTPN22 BTK BCR PLCG2 CD22 BLNK LYN PMC3593794__F6 CDK5 phosphorylation substrates during neuronal migration CDK5R1 DCX CDK5 LIMK1 CDKN1B ARHA NDEL1 HEL-S-15 PMC9450390__F2 DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy CXCL9 STAT3 HMGB1 TBK1 CGAS MAVS GSK3B IRF1 IRF3 SSB CXCL8 MYD88 IFNG STAT1 TLR4 PMC9450390__F1 DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy PRF1 GZMA SSB PMC3627353__F3 Genes and signaling pathways involved in ureter development TBX18 BMP4 AGTR1 SHH KIT HCN3 SMO TSHZ3 CTNNB1 PMC9471952__F2 Neuregulin-1, a potential therapeutic target for cardiac repair ERBB3 NRG1 NLRP3 ERBB4 EGFR GSK3B ERBB2 AREG CTNNB1 PMC2603427__F5 Hierarchical layout of the EGFR1 pathway downloaded from the HPRD pathway database STAT3 CAV2 TNK2 CASP9 JUN CEACAM1 RAF1 PLD2 PLSCR1 SMAD2 RGS16 CTNND1 PRKCZ MYC PRKCB CRK PLCG1 STAT5B PRKCA SH3GL2 GRB2 SRC PMC7199893__F4 FATE OF ALT-INHIBITED CANCER CELLS RAD52 ATR TSPYL5 TOP3A SMC6 RAD51AP1 PML SMC5 FANCM BLM SLX4IP PMC9546849__F3 RNA m6A writer WTAP in diseases: structure, roles, and mechanisms EGF WT1 IFNAR1 WTAP IRF3 PMC8599985__F2 Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function STAT3 CSF2 TNFAIP3 PAP TLR4 EGFR FOXP3 PMC2603427__F6 Hierarchical layout of the B-cell receptor pathway downloaded from the HPRD pathway database CSA2 CD79B SYK HCLS1 PRKD1 SHC1 NFATC2 CARD11 PIK3R2 PPP3R1 GSK3B RPS6KA1 BRAF CD22 PPP3CA MAPK8 MAPK3 MAPK14 RB1 TEC BTK FYN CDK6 PLCG2 CREB1 CDK4 MAPK1 PTPN18 RPS6 CASP9 BLNK PIK3AP1 NFATC1 PTK2B CBL GSK3A RPS6KB1 CDK2 NFATC3 BCL6 PMC8599985__F1 Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function EGF KLF2 JUN EGFR CRKL IL7R PTEN MYC FOS IRS1 EIF4E RHEB TSC2 NGF TSC1 CXCR1 IL8RB GRB2 JAK1 SRC TYK2 PMC6332659__F3 Tissue-specific gene regulatory network of the top KDs in psoriasis ZAP70 C6 TAPBP CCL18 SELPLG MCL1 IFI30 CYCS CTSS TNFRSF25 CLTB MYC HLA-E CD74 IL16 CSF1R CD6 SRGN TNFRSF14 FITM2 PLEKHO2 IL10RA VEGFA LTB TRAF1 GRB2 HLA-C HLA-A CYBB IL15 HEL113 GNL3 BAD FAS TIMP1 TRADD TNFAIP3 CTSH RAB31 HEL-S-62p CD27 EGFR NFKB2 HLA-DRB1 PSMD1 HLA-F F2R HLA-G CD33 IL18 THYN1 CHUK HSDL1 IL1B BIRC3 CD48 CD81 IKZF1 CD2 CD14 GZMA YBX1 HLA-DQB1 CBL C2 BBS4 NFKBIA LYN TNFSF10 REL CD3E PS1TP5BP1 LCK PMC7068214__F7 Investigation of the Genome-Wide Genetic and Epigenetic Networks for Drug Discovery Based on Systems Biology Approaches in Colorectal Cancer ANGEL2 ENPP4 PTK6 MAFG SPARC GP5 GRID2 STAP2 ANP32E STAC PPP2R3B WDR4 AHR WNT4 SMC2 ARSF SLC16A5 ARMC8 TMEM39A CBLN1 VWF GDNF STK17B GNAL RORB STOM MUC2 PMC9546849__F6 Other functions of WTAP in cancers CA4 MMP7 WT1 EGFR APC GSK3B WTAP MUC1 BCL6 MMP28 CTNNB1 PMC6826908__F1 Canonical Wnt signaling pathway RNF43 APC ZNRF3 GPR49 PMC2361115__F1 Cytoplasmic/traditional and nuclear modes of the EGFR signalling pathway STAT3 EGF EGFR CCND1 PMC4847613__F6 Regulation of trophectoderm (TE) lineage specification by mevalonate pathway CDX2 HMGCR RHO TEAD4 GATA3 PMC5458287__F1 Targeting HOX/PBX dimers in cancer BAX ATF3 CASP8 EGFR CASP3 PMC8801368__F1 Progesterone Receptors in Breast Cancer CXCL12 WNT4 CXCR4 PMC5356509__F2 Intrinsic and extrinsic apoptotic pathways, the TRADD/NFKB survival pathway, and the growth factor (GF) receptors PI3K/AKT pro-survival signaling axis in CSCs BAX BAD TRADD FADD PMC9225081__F2 Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice RAD18 RAD51 PCNA PMC6523766__F2 Metabolic reprogramming in RCC SDHB FAS FH GLS HEL-S-133P HEL-S-68p HEL-S-162eP PMC6523766__F1 Genetic mutations, HIF-1A activation and metabolism of RCC TGFA HEL-S-133P ELL PMC7226520__F3 Adipocytokine signaling pathway in humans (KEGG hsa04920) STAT3 NR1C1 LEP TRADD LEPR NPY SOCS3 AgRP MTOR TNF TRAF2 PMC5486005__F1 Key miRNAs in the resistance to BC treatment STAT3 PTEN MTOR PMC5831670__F4 Inhibition of Butyrylcholinesterase with Fluorobenzylcymserine, An Experimental Alzheimer’s Drug Candidate: Validation of Enzoinformatics Results by Classical and Innovative Enzyme Kinetic Analyses HMGB1 IL6 MIF PMC7226520__F7 Comparative downstream pathway analysis of the effect of the adipocytokine pathway in breast cancer using the SEanalysis web tool for super enhancer associated regulatory analysis KRT18 MLPH TRAF4 ZMYND8 CITED4 C9orf50 EDN2 PCP4 ERRFI1 PARD6B AMOTL2 PMC5642638__F2 Role of PLZF as a tumor suppressor in prostate cancer KLK4 EGF FOXO3A PBX1 BRAF KRAS PMC7774091__F8 Proposed apoptotic pathway for the anticancer compound, SYA013 BAX PAF1 MCL1 BCL2 PMC6162242__F8 A schematic for an miR-532-5p/KRAS-NAP1L1/P-ERK/ETS1 feedback loop KRAS PMC9654658__F1 Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response IL15 IFNG TH IL10 HLA-DRA TGFB1 COIL TNF PMC8897182__F2 Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension BMPR2 LDLR GLA PAH TGFBR1 PMC6776600__F11 Complement inhibitors target different levels and steps of the complement cascade MASP2 HEL-S-62p CP PMC9654658__F3 Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response FAS MOS ASPH ARC PMC8416576__F4 Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis EGF A1BG TGFB1 AMBP SPARC SERPINA1 HEL-S-84 PLG RBP4 VEGFA APOA4 PRKCSH HEL-S-125m PMC6250919__F1 Genetic polymorphisms more consistently associated with non-alcoholic fatty liver disease and their suggested physiopathological role PNPLA3 TM6SF2 MBOAT7 GCKR PMC8416576__F5 Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis ACO2 HEL-S-7 HEL-S-89n GANAB HEL-S-30 BCL2L1 HSPD1 HYOU1 CCT8 PSMC6 HEL-S-102 HEL-S-32 MDH2 EEF1A1 PMC8343402__F5 Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants NAPA PSMB6 STX6 MYC PLK1 MAPK3 NF1 CENPP SHH SMC2 POLE NOTCH1 HEL-S-44 TAOK1 NAPB SPTBN1 EZH2 PREB PSMD13 RPN2 GCLC RPN1 COG2 XBP1 HEL-S-276 NAPG AMT HEL-S-72p GOLIM4 PSMD10 PSMA8 B9D1 PSMB8 RRM1 AFF4 RRM2 HEL-S-89n NPHP1 CC2D2A RBPJ VHL DYNC1LI2 PSMD9 EP300 DCTN1 STXBP1 NCAPG GPX4 KDELR3 GOSR2 HSPA2 PSMB10 TUBB4A PSMB3 C7orf24 DPAGT1 PRIM1 FOS ATF3 BARD1 MCM7 FOXO1 AURKB CDC45 DPM1 MCM3 GOSR1 MCM6 MCM2 B4GALT2 HEL-S-64p SIRT1 COG5 MAN1A2 TCTN3 MAN2A2 MAN2A1 MGAT1 LIMD1 STT3A KNTC1 DYNC1H1 OPTN CDC2 TUBA1A JUN KIF11 PPP2R5B SEC31A HIF3A PCM1 FOXO3A NFKB1 CHEK1 COG8 HEL-S-102 COG1 STT3B PMC4490948__F2 IRE1–RIDD–RIG-I pathway MAVS XBP1 TRAF2 PMC4357785__F6 Important pathways in HCC Shown is the mTOR/AKP/PIP3 pathway that contributes to transformation of nodules into metastatic counterparts BAD CRB2 RAF1 RHO MTOR GHR PMC9679411__F6 Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients CXCL10 PMC5330314__F7 High-fat diet-induced complement activation mediates intestinal inflammation and neoplasia, independent of obesity HEL-S-62p IL1B PMC3593794__F3 PAFAH1B1 (platelet-activating factor acetylhydrolase 1 regulatory subnuit 1, formerly known as LIS1)-binding partners CDC42 DAB1 DCX PAFAH1B1 NUDC IQGAP1 NDE1 HEL-S-303 RAC1 NDEL1 PMC6911354__F1 MYC as master regulator of proliferative lipid metabolic pathways: fatty acid synthesis, fatty acid elongation, and glycerophospholipid synthesis ACLY LPA ELOVL2 FAS SCD CDS1 FASN ACACA MYC ELOVL6 PMC7076845__F7 Modulating NF-kappa B signaling pathway of DHI against UA SYK EGF LTA LTBR TRADD TIRAP LAT TRAF3 TRAF6 MYD88 NGF BTK PLCG2 COX2 BCR GADD45B ATM CYLD IL1B CD14 BLNK LTB CNTF TRIM25 TRAF5 TRAF1 LYN EDARADD LBP TRAF2 EDAR LCK PMC10584331__F2 Reverse of liver fibrosis by inducing ferroptosis by bioactivated compounds in HSCs TF ZFP36 GPX4 FGF21 BAP1 HEL-S-64p HEL-75 PMC7216212__F3 Dichotomic Role of Macrophage Migration Inhibitory Factor in Neurodegeneration HDAC3 GFAP MIF PMC10584331__F1 Ferroptosis mechanisms LOX GPX4 LPCAT3 HEL-75 ADA PMC2835321__F6 Retrograde mechanisms in NMJ formation GDNF RET PMC3069769__F1 Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy RHEB MAPK1 TSC2 TSC1 SGK1 PTEN DEPTOR IRS1 EIF4E MAPK3 PMC7297083__F2 Interaction between pattern recognition receptors (PRRs) from dendritic cells (DCs) and VLPs CD80 FER PMC4398389__F1 Unraveling the Molecular Signatures of Oxidative Phosphorylation to Cope with the Nutritionally Changing Metabolic Capabilities of Liver and Muscle Tissues in Farmed Fish NDUFB6 NDUFB2 NDUFB5 NDUFB11 NDUFS5 NDUFV2 CYC1 NDUFA7 NDUFA13 NDUFA10 NDUFS3 COXFA4 COX6A1 NDUFS6 ND6 NDUFB4 NDUFB1 NDUFA3 UQCRH ND2 NDUFC1 ND1 SDHD UQCRC1 SDHA SDHB ATP8 UQCRFS1 ATPAF2 ZNF183 SDHC NDUFB8 NDUFA12 NDUFV3 NDUFA9 UQCR10 SURF1 NDUFB9 NDUFA6 COX7C ATP6 UQCRQ NDUFA11 NDUFS4 SDHAF1 NDUFAF2 UQCRB UQCRC2 NDUFB7 NDUFB3 COXFA4L2 NDUFC2 OSCP1 SDHAF2 NDUFB10 NDUFA2 PMC6937732__F8 Schematic model depicting the promotion of esophageal squamous cell carcinoma (ESCC) cell metastasis STAT3 GSK3B SRC PMC4284611__F7 A model of enhanced cancer invasiveness and proliferation elicited by adjacent fibroblasts TSPAN12 CXCL6 CTNNB1 PMC9315629__F5 Circular RNA in Brain Tumor Development CD44 FBXW7 ITCH AKT3 WWOX VEGFA PMC7762545__F3 The conventional Kyoto Encyclopedia of Genes and (KEGG)-determined ccRCC pathway in the three cancer nodules with respect to the normal tissue from the right kidney EGLN1 RBX1 ARNT2 TGFA CREBBP EP300 HIF1A VEGFA EGLN3 EGLN2 VHL PMC6332805__F3 Selective Autophagy degrades cell cycle proteins CDC2 RAD51 CHEK1 CDK2 CCND1 STUB1 VHL HDAC6 PMC6332805__F2 Different types of autophagy ATG12 ATG14 ATG5 PMC9315629__F4 Circular RNA in Brain Tumor Development FOXM1 RFX3 CDC45 ENTPD7 FOXO3A ABCC3 MMP2 VEGFA FLNA NUP98 SKA3 PMC9315629__F3 Circular RNA in Brain Tumor Development ZNF292 PARP4 SHKBP1 CFH MMP9 SOX4 PMC6177508__F1 Schematic model for phosphorylation-dependent YAP translocation by DVL LATS2 CTNNB1 PMC6034857__F11 MAPK signaling pathway ECSIT EGF JUN FAS RAF1 MOS CD14 ATF2 GRB2 TNF FLNA TRAF2 PMC7886700__F1 Growth factor mediated activation of AKT1 GSK3B PMC6034857__F10 Transcriptome study on Macrobrachium nipponense hepatopancreas experimentally challenged with white spot syndrome virus (WSSV) SYK EIF4B BAD EBP RBL2 PTEN CD19 MTOR ME1 IRS1 EIF4E RHEB TSC2 TSC1 BCR CLU RXRA MEI1 MDM2 PMC2590699__F1 Current model for Okazaki fragment maturation PIF1 DNA2 FEN1 PMC3165799__F1 Schematic diagram of the ER stress response RHEB TSC1 ATF4 EIF2A PMC9116919__F2 Vascular Calcification in Chronic Kidney Disease: An Update and Perspective STAT3 OGT LRP5 MTOR RUNX2 CTNNB1 MYD88 SOX9 TLR4 PTH PTH1R SIRT1 MSX2 PMC11361845__F5 Analysis of changes in the proteome and phosphoproteome according to DNK72 treatment in patient derived glioblastoma cells GAL LRRK2 RHO PMC10378680__F5 The Piezo1 Mechanosensitive Channel in Heart Failure PIEZO1 IL10 TGFB1 CCR2 IL6 IL1B PMC3175149__F1 IL-33 release and signaling via ST2L IL33 IRAK1 TRAF6 MYD88 PMC8835847__F8 microRNA-21 Regulates Stemness in Pancreatic Ductal Adenocarcinoma Cells CD44 CD24 CXCR4 CTNNB1 PMC4863577__F1 Hh pathway critical components which could be targeted by potential antibasal cell carcinoma drugs.Notes: The mechanism of action of each single drug is explained in the text SUFU EGFR SMO PMC8167111__F6 FGF2/MAST4/ERM pathway in SSC self-renewal CXCL12 CXCL5 BCL6B FGF2 PMC7753217__F2 IFITM3’s mode of action in cancer KLF4 STAT3 STAT1 IKZF1 STAT2 SMAD2 IFITM3 SMAD4 MTOR CTNNB1 PMC12025613__F1 Key pathways involved in hepatocellular carcinoma metastasis SMAD2 APC SMAD6 GHB2 MTOR CTNNB1 GLI3 TGFBR1 PMC6031408__F8 Schematic describing the proposed role of MYC and CDKN1A in Wnt/Beta-catenin (CTNNB1) and angiopoietin pathway-dependent hyaloid vessel regression CDKN1A LRP5 LRP6 WNT7B CTNNB1 PMC3712086__F5 Diagram illustrating the signaling mechanism of how CARD9 may be inhibiting apoptosis from TNF-alpha TRADD TRAF2 CARD9 FADD PMC5863305__F1 Role of miR-146a in diabetic microvascular complications STAT3 ERBB4 IRAK1 IRAK2 TRAF6 NOTCH1 CP PMC3069839__F5 Regulation of Atm pathway genes after Rif-Phen-MCT TP73 CSA2 JUN BRCA1 CHEK2 ATM MDM2 PMC7142218__F1 FGF2 functions through FGFR dependent or independent pathways MAVS FRS2 FGFR4 FGFR1 FGFR3 IRF3 IRF7 GRB2 FGF2 FGFR2 PMC6345046__F5 Relationship between autophagy and cytokines GABARAP TLR3 TLR4 MTOR TRAF6 ATG5 PMC3146511__F6 Expression and Functional Roles of Angiopoietin-2 in Skeletal Muscles MYB DLGAP5 KIF11 UBE2C NUF2 RRM2 APC KNTC2 IL6 LARP1B SPC25 MCM10 CDC45 CENPA NFATC3 PMC6814598__F1 Damaged nuclear DNA export, sensing and clearance in aging-related inflammation TBK1 CGAS IRF3 PMC8125157__F2 Cholinergic Modulation of Neuroinflammation: Focus on A7 Nicotinic Receptor STAT3 SOCS3 PMC6678477__F1 Rac1 activation is regulated by GEFs and GAP TIAM1 SOS1 VAV2 RAC1 PMC10380735__F1 Molecular Mechanisms of Neuroinflammation in Alzheimer’s Disease, the Consequence of Neural Cell Death FAS TRADD APAF1 FADD PMC3380518__F1 IL-33 signalling pathways IL33 SIGIRR IRAK1 IRAK4 MYD88 PMC7349525__F3 PD-related proteins and chaperones involved in proteostasis: Other well-characterized PD-related proteins, their cellular localization and functional pathways involved are depicted in this figure VPS35 BAG5 BAG2 PINK1 LRRK2 BAG1 DNAJC6 CDC37 PMC9170603__F3 MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers IL-21 STAT3 IL10 IL27 IL11 IL6 SRC IL9 PMC9570382__F1 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer FGF9 PMC9570382__F3 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer IGF2BP1 SMIM30 EZH2 PMC9570382__F2 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer MAP3K2 EPHA2 PBX3 KRAS PMC9292941__F3 Genome of a nonphotosynthetic diatom provides insights into the metabolic shift to heterotrophy and constraints on the loss of photosynthesis PC CS TNLG7C PMC7058049__F9 Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation TNFAIP3 RUNX2 PMC3980848__F1 MicroRNA Regulation of T Helper Cell Differentiation and Plasticity DUSP5 SOCS1 AGO2 PRDM1 PTEN MTOR TRAF6 DROSHA IFNG PTPN22 IL2RB DGCR8 FOXO1 TEF PMC11539687__F2 This figure illustrates the neuroprotective mechanisms of GLP-1 receptor agonists (GLP-1RAs) in neurons and microglia, highlighting the key molecular pathways involved in neurodegeneration and inflammation TFAM BAX NLRP3 MTOR PMC9457923__F1 ABCC4 inhibition as a potential therapeutic strategy against SHH-MB SUFU PTCH1 SHH SMO PMC3980848__F3 MicroRNA Regulation of T Helper Cell Differentiation and Plasticity SOCS1 NCOR2 STAT1 FOXP3 DROSHA BCL6 PMC7861947__F6 Probable mechanisms of apigenin against liver fibrosis TGFA MMP2 PMC4836414__F1 The butanone biosynthetic pathway HEL-S-133P HPR C2 PTS PMC6694253__F3 Sub-network of SNHG12 TRIM7 SYK BAD RAF1 PTEN MTOR PLK1 KIF23 MGA SMARCE1 HLA-G BCR PI3 WDR4 NRAS MDM2 TDG HRH1 EIF4B NPNT TWF2 RAVER2 RBL2 CD19 HEL70 TEX19 ARHA EIF4E SPN RHEB TSC2 TSC1 HEL-S-162eP RXRA STX7 MEI1 BCL2 PMC8446364__F1 She Doesn’t Even Go Here: The Role of Inflammatory Astrocytes in CNS Disorders GFAP MAFG IL1A CCL5 MTOR CXCL10 CCL2 IL1B PMC6826838__F7 Complement and coagulation cascades signaling pathway and RT-qPCR verification VWF CD59 FH C7 CPB2 HEL-S-62p F5 CR2 F11 CS ITGAX BOLL TFPI C2 F10 C9 PC PMC9265562__F3 Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease PINK1 BNIP3 FUNDC1 OPTN BCL2L13 PMC7279331__F3 Calmodulin and protein kinase C (PKC) modulating critical features of KRas-driven tumourigenesis RAF1 BCL2 RAC1 PMC7279331__F2 Key signalling events modulated by Ca2+/calmodulin and decisive for cell proliferation and survival HBEGF RAF1 EGFR GRB2 KRAS PMC4916957__F2 IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance NRP1 PTEN PMC3888876__F2 MONOGENIC AUTOINFLAMMATORY DISEASES: DISORDERS OF AMPLIFIED DANGER SENSING AND CYTOKINE DYSREGULATION CARD14 NLRP3 BCL10 JAK1 TNF TYK2 PMC7056705__F2 Major mechanisms underlying induction of the host immune response by VPM1002 and M CGAS AIM2 IL1B PMC11726887__F10 Effect of echinacoside in HepG2 cells SLC3A2 GPX4 FACL4 SLC7A11 PMC9570382__F4 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer CDK6 EGFR CDK4 PMC3534598__F1 Cartoon depicting the role of sialidases during the multistep process of myogenesis NEU2 NEU3 EGFR NEU1 PMC6756057__F2 Schematic overview of genetic and epigenetic abnormalities in Wnt pathway components in MM and drugs that target canonical Wnt signaling AURKA APC LRP5 LRP6 MYC CTNNB1 BCL9 SOST RNF43 DKK1 ZNRF3 TBP CYLD CCND1 PMC2748802__F18 Hypothesized descending pathway for translating emotional states or appetitive need for food, salt or water into goal-directed motor tasks NTS SI ARC PMC3323190__F7 Summary of the effects of leptin in the hypothalamus of control (A) and ob/ob mice (B), as revealed by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) and 13C High-Resolution-Magic Angle Spinning (HR-MAS) NPY ARC AgRP PMC8656934__F2 Targeting Metabolism to Control Immune Responses in Cancer and Improve Checkpoint Blockade Immunotherapy CD80 FAS TSC1 HEL-S-133P CD36 HK2 APC FOXP3 MTOR MYC PMC8307196__F7 Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells EGF STAT5B EGFR PMC4376961__F3 Schematic overview of autophagy machinery and its regulation by sphingolipids ATG101 ATG3 ULK1 ATG14 BNIP3 PMC8656934__F3 Targeting Metabolism to Control Immune Responses in Cancer and Improve Checkpoint Blockade Immunotherapy FAS HEL-S-133P CD36 HK2 ARG1 PMC4376961__F2 Key events in the apoptotic pathway and regulation of apoptosis by sphingolipids BAX BAD BCL2 BMF FADD PMC5518849__F1 An overview of one-carbon metabolism and the established/future therapeutics that target this pathway MTHFD1 PHGDH DHFR TYMS PMC9358979__F1 Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus CGAS PINK1 NLRP3 IL1B PMC3609811__F1 Gene Expression Profile of the Hippocampus of Rats Subjected to Chronic Immobilization Stress CD44 VWF ITGB6 ITGA4 CD36 NPNT CHAD COL3A1 CD47 SDC3 PMC3367552__F6 Interaction map showing potential links between the Par proteins and components of the Hippo pathway PALS1 RHO CTNNB1 PMC5892236__F1 Resveratrol inhibits the mTOR signaling pathway in the repair of SCI RHEB TSC2 RICTOR MTOR IRS1 PMC3609811__F2 Gene Expression Profile of the Hippocampus of Rats Subjected to Chronic Immobilization Stress CD40 FLT3 LTA OSM IL3 EPO IL21R CCL2 IL-21 CCL23 INHBE FLT4 CCL21 OSMR IF2D TPO KDR BMPR2 CSF2 TNF LTB CCL14 TSLP CCL25 CXCR4 EDAR CCL20 EGF CCL22 FAS LEP EGFR CCL26 IL2RG CSF3 MPL IFNK IL2 XCL2 IL9 NGFR LIF BMP7 IL4 CNTF IL24 PRL BMP2 IL6ST IL23A TNLG7C PMC8215697__F1 Developing Clostridia as Cell Factories for Short- and Medium-Chain Ester Production HBD ACR PMC5396623__F4 SPARC overexpression alters microRNA expression profiles involved in tumor progression MMP16 STAT3 IL37 IL36RN IL36G IL36A IL36B S100A12 TNF CTSC PMC8748963__F9 NLK/SRF/ELK Pathway HEL114 EGR1 RHO NLK PMC6627638__F10 Epigenetic regulation of survivin in transformed cells KDM4A KDM2A PMC8626591__F1 Combined treatment of non‐small cell lung cancer using radiotherapy and immunotherapy: challenges and updates P2RX7 CD40 CD80 HMGB1 PMC6716297__F7 SUCO related genes involved in the cell cycle pathway DBF4 CDC20 PCNA CDC6 STAG1 SMC3 SMAD4 MYT1 ORC3 SKP2 RAD21 CDK7 E2F4 CDC45 CDK2 MDM2 PMC11837758__F1 The metabolic pathway for the biosynthesis of monocyclic aromatic chemicals HEL107 XK PTS XDH DMD GALP PMC6678865__F4 Altered metabolism as the source of nadph biosynthesis GOT2 PSAT1 ME1 HEL-S-26 NNT PSPH PMC3282946__F4 miR-23b and tretinoin, which was associated with this miRNA in thyroid cancer, shared the common target genes, ALDH1A1 and ALDH1A2 MAX IDE FAS BRAF CD14 HIF1A MTOR TNF EIF4E RHEB TSC2 BDNF TRAF2 PMC6832683__F10 Schematic diagram illustrating the distinct roles of Nrp2 in corticostriatal pathway development, maintenance, and function SPN NRP2 PMC1885811__F4 Web-accessible pathway navigator RIGI TRADD TIRAP AMTN TRAF6 PMC10179549__F10 HMGB2 in the development of the diseases CGAS GC FBP1 MMP2 HMGB2 CTNNB1 PMC7473503__F2 Androgen receptor pathway inhibitors and their mechanism of action CYP17A1 PMC6770608__F10 Diallyl trisulfide (DATS) protected the brain tissue against the damage induced by ischemia/reperfusion (IR) RBX1 KEAP1 HEL-S-44 PMC7412691__F6 Schematic diagram of the mechanism underlies miR‐155 function in chondrocyte apoptosis and catabolic activity PIK3R1 MMP3 IL1B PMC10926087__F1 Activated hedgehog gene pattern correlates with dismal clinical outcome and tumor microenvironment heterogeneity in hepatocellular carcinoma GPR161 CDON BOC GSK3B ADRBK1 EVC2 EVC DISP2 KIF7 SUFU PTCH1 SMO CSNK1A1 GLI3 PMC1852964__F2 APC-Beta-catenin-Tcf (Wingless-Wnt signaling) pathway APC ERBB2 CTNNB1 PMC3965671__F6 Mechanisms by which Th17 and Th22 pathways contribute to psoriasis and atopic dermatitis CCL11 CXCL1 CCL26 CXCL2 CCL5 CXCL8 CCL24 IL25 IL16 GC AHR CCL8 CCL20 IL1B PMC8096904__F5 Control Analysis of Protein-Protein Interaction Network Reveals Potential Regulatory Targets for MYCN MAX PIK3CA EGFR SMAD2 PIK3R1 SMAD4 PTEN IGF1R MYC TGFBR1 FGFR2 MGA TGFBR2 ACVR1B MLX FGFR1 MXD3 MYCL CCND1 MLXIP MXI1 ACVR2A MXD1 MXD4 MNT KRAS HRAS ERBB2 FGFR3 PMC4666791__F1 Schematic diagram shows major signaling pathways stimulated by IFNA/B (mediated by the type I IFN receptor) and viral pathogen-associated molecular patterns (PAMPs) and/or ICs-containing nucleic acids (mediated by endosomal TLRs) STAT3 JUN IRF9 MAL IRF3 IRF7 IL6 TRAF3 TRAF6 IRAK4 FOS MYD88 STAT1 IFNAR2 IFNAR1 TYK2 PMC3965671__F5 The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs and Skin CCL11 CXCL1 CCL26 CXCL2 CCL5 CXCL8 CCL24 IL25 IL16 GC CCL7 AHR CCL20 PMC3965671__F4 Immunopathogenesis of inflammatory bowel disease (IBD) MLN CXCL1 GC IL33 NOD2 CXCL2 CXCL8 CCL20 IL1B PMC8579729__F1 Complement in ischaemia–reperfusion injury and transplantation MASP1 MASP2 HEL-S-62p CS PMC7923337__F8 Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer WDR3 GATA4 YAP1 PMC9619106__F7 Transcriptome analysis reveals the proline metabolic pathway and its potential regulation TF-hub genes in salt-stressed potato PRODH2 PRODH PMC8436174__F1 HER2-Directed Therapy in Advanced Gastric and Gastroesophageal Adenocarcinoma: Triumphs and Troubles EGFR PTEN MDM2 MTOR PMC8494520__F2 Immunology and Immune Checkpoint Inhibition in Ovarian Cancer – Current Aspects CGAS CCL5 CXCL10 PMC4508762__F3 Transcripts regulating the Wnt signaling pathway are putatively affected by up-regulated miRNAs expression in the PCOS patients when compared with control RBX1 LEP SIAH1 ROCK2 STOM APC CER1 SMAD4 SKP1 ARHA NLK DAAM1 PMC3185234__F1 Enterohepatic circulation of the bile ABCG8 ABCG5 CYP7A1 PMC6727741__F8 WDR92 in the axonemal dynein assembly pathway SPAG1 DNAAF2 RUVBL1 COIL RUVBL2 HEL-S-94n PIH1D1 PIH1D2 RPAP3 PMC5166530__F2 CTHRC1 in multi-signaling pathways SMAD1 WNT3A SMAD2 ROR2 LRP5 SOX2 CTHRC1 LRP6 MMP9 ARHA DPAGT1 CTNNB1 BMP4 WNT1 PMC6986204__F2 Molecular mechanism(s) regulating human Beta-cell proliferation DYRK1A IGF1 HEL57 GSK3B IGF1R IRS1 PMC4163633__F1 Innate recognition of HCV RNA TBK1 MAP3K7IP1 MAVS TRADD TLR3 TRAF5 IRF3 TRAF3 ISG15 TRAF6 PELI1 TRAF2 PMC7589980__F1 Susceptibility genes present in the double-strand DNA break repair pathway for ovarian and breast cancer and its different correspondent risks levels in each disease BRIP1 RAD51D ATR RAD50 BRCA2 NBN BARD1 RAD51C MRE11A BRCA1 CHEK2 CHEK1 ATM PALB2 PMC4485443__F1 Structural determinants of SMAD function in TGFB signaling SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC8387325__F2 Recent findings within the C. elegans neuro-gut axis SGK1 NPY PMC2953617__F2 JS genes implicated in the Shh, Wnt, and PDGFA signaling pathway CEP290 PCM1 ARL13B SHH AHI-1 INPP5E PMC3632658__F1 Interplay between viruses and host mRNA degradation LSM1 DCP2 LSM3 XRN1 MGP LSM5 LSM7 RNASEL DCPS LSM6 LSM4 LSM2 PMC2886162__F5 SIRT1-dependent Regulation of Chromatin and Transcription: Linking NAD+ Metabolism and Signaling to the Control of Cellular Functions TF NMNAT1 NAMPT SIRT1 ENAM PMC2810404__F6 Hepatocyte expression of Serum Response Factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice HSD3B2 RAD51 CDC20 EGFR IGFALS IGF1 MCM10 HSD17B2 MCM5 GRB2 MCM2 CCNB1 GHR TOP2A PMC4257614__F4 Accounting for eXentricities: Analysis of the X Chromosome in GWAS Reveals X-Linked Genes Implicated in Autoimmune Diseases PARVB FANCM TGFBR1 MOBKL1A GPR34 GTF2F1 ECHDC2 RUSC2 ADAM15 APP EFHC2 HDAC2 TNK2 IL13 HAND2 GAGE12H GAGE10 CST11 RORC CAPNS1 RIBC2 MAGEE2 FZD4 APPBP2 CENPA B3GNT2 IL13RA2 GNA13 PMC2693450__F3 Lipodystrophies: Disorders of adipose tissue biology LPA TG CDA PMC7185127__F2 Regulatory mechanism of mitochondrial quality control FIS1 OPA1 MFN1 FUNDC1 MFF PMC3356061__F2 Molecular pathway of activation of autophagy ATG101 ULK1 UVRAG AMBRA1 MTOR PMC7738881__F8 Schematic model depicting how 14-3-3σ performs anoikis resistance effects in HCC EGF EGFR CASP3 PMC3840213__F8 Graphic summary of factors regulating Beta-cell proliferation and size as a function of pancreas developmental stages PRLR PRL IGF2 PMC6163343__F1 HH-GLI signaling pathway ADRBK1 EVC2 EVC GPR161 HHIP BOC SUFU PTCH1 BCL2 SMO GAS1 GLI3 PMC8610101__F1 Complement Pathways HEL-S-62p C2 C9 C4A C4B_2 PMC4420620__F2 Novel functions of viral anti-apoptotic factors IRF3 IRF7 IRF4 JAK1 TYK2 PMC4420620__F1 Novel functions of viral anti-apoptotic factors ATG3 UVRAG PMC5086033__F1 Microenvironmental Regulation of Hematopoietic Stem Cells and Its Implications in Leukemogenesis CDH2 CXCL12 LEPR FOXC1 MSC PTPN13 CTNNB1 PMC8533566__F7 SOD3 Levels Is Detrimental to Retinal Homeostasis SLC17A6 RAB34 STX18 STX3A PMC4087507__F1 NOD2/TLR4 signaling pathway TLR4 NOD2 TRAF6 MYD88 PMC7356051__F1 Mammalian Arg/N-degron pathway UBR5 UBR1 UBR4 NTAQ1 NTAN1 ATE1 PMC3141878__F1 TLR4 signaling cascade and evidence for modulation by neuropathic pain and opioids TIRAP TLR4 TAB3 CD14 IRAK4 MYD88 PMC2864389__F1 PI3K/AKT signaling pathway TSC2 BAD FOXO4 PI3 MDM2 PMC6265572__F6 MiRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults LATS1 LATS2 APC GSK3B IGF1R CTNNB1 PMC4069271__F1A Hypoxia-Inducible Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (HIF-1B): Is It a Rare Exception? AHR VHL PMC9168372__F2 Anti-Inflammatory Activities of Betulinic Acid: A Review VCAM1 TNF PMC6322862__F1 Schematic diagram of a simplified model for glucose-mediated mitochondrial transport regulation MAX OGA GAA OGT PMC7897195__F4 SFRP2 overexpression in tumor endothelium leads to enhanced tumor angiogenesis via the Wnt/Ca2+signaling pathway TEC FZD5 NFATC3 PMC7897195__F2 SFRP2 and the canonical Wnt signaling pathway APC LRP5 LRP6 CTNNB1 PMC4861365__F1 The Fanconi anemia/BRCA repair pathway FANCD2 ATR ATRIP RAD51 BRCA1 USP1 BRCA2 PMC7057837__F1 Role of RUNX Family Transcription Factors in DNA Damage Response FANCD2 BAX ATR CDKN1A ATM MDM2 GADD45A PMC9251345__F5 Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19 HTRA2 BAX ALG12 PINK1 FIS1 OPA1 ALG10 AIP ALG14 ATG5 APAF1 DIABLO PMC8039963__F7 Genetic and molecular signal dynamics that ZEN mainly affected during PF assembly TEAD2 FZD2 AXIN1 WAS SMAD4 WNT4 ID1 YAP1 PMC2556568__F2 Molecular processes that handle — and mishandle — dietary lipids TG APOBEC1 ABCG8 ABCG5 ACAT2 DGAT2 NPC1L1 SAR1B PC APOB ABCA1 PMC7057837__F3 Role of RUNX Family Transcription Factors in DNA Damage Response FANCD2 ATR RUNX1 BLM PARP1 RUNX3 PMC5847265__F1 Pediatric Pharmacogenomics: A systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children LPL APOC2 APOC3 APOC1 SQLE APOE ABCA1 LIPC APOA4 ABCG8 ABCG5 HMGCR SCARB1 CYP7A1 LDLR SOAT1 APOB PLTP FDFT1 PMC4436943__F1 Wnt/Beta-catenin signalling pathway APC LRP5 LRP6 CTNNB1 PMC5078078__F6 NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-λB signaling ZAP70 TBK1 TNFRSF1B LTA CSF1 LTBR RAF1 TNFRSF10B CD27 EGFR NFKB2 CARD11 RELB IKBKE IRAK1 MTOR TRAF3 TRAF6 CSF3 IKBKG MAPK3 IFNG CARD10 NOD1 EIF2AK2 JUN CSF2 EGR1 TNF RELN FOS TNFSF14 MAP3K1 SLC20A1 IKBKB TNFSF10 FADD PMC10526378__F3 Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors STAT3 SOCS3 PMC10526378__F1 Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors STAT3 EGFR MTOR PMC9099213__F1 “Self-Sacrifice” of ImmuneCells in Sepsis NLRC4 GSDMD NLRC3 PMC2888584__F7 Endothelin-1 Inhibits Prolyl Hydroxylase Domain 2 to Activate Hypoxia-Inducible Factor-1A in Melanoma Cells HEL-S-28 MTOR VEGFA PMC7802795__F13 Possible mechanism of anticancer activity of SnO2-ZnO/rGO NCs NPS CASP3 PMC11275100__F1 PARPi effect in cancer cells and immune cells CGAS BRCA1 BRCA2 PMC3496044__F7 Sialic acid biosynthetic and degradative pathways NANP GNE CMAS PMC5823602__F4 UBASH3B promotes tamoxifen resistance and could be negatively regulated by ESR1 UBASH3B PMC5023837__F2 Ingenuity Pathways Analysis of the identified methylated targets TEKT4 NKX6-2 PRKAB2 MMP3 MIA3 HSPB7 NEF3 AKAP9 CTNNB1 CP PMC1487177__F7 AKT-1/PKB Signaling INSR PTEN PMC5329888__F3 Sex determination within individual XY supporting cells depends on the level of Sox9 expression.A SOX9 SRY FGF9 CTNNB1 RSPO1 PMC10529750__F6 Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis SIRT3 MRGPRD PMC7854989__F2 Novel insights provided by single cell transcriptomics regarding hepatocytes and hepatic NPCs in nomal liver and during various injuries and pathological conditions CXCL9 CD36 NGFR S100A6 S100A8 CCR2 NRP1 FABP4 LPAR1 VEGFA SPP1 TREM2 CD9 PDGFRA BMP2 S100A9 TWEAK IL1B PMC8250138__F2 Tetraspanins: Novel Molecular Regulators of Gastric Cancer TSPAN9 CD81 EGFR CD82 TSPAN5 CDK4 PMC8250138__F1 Tetraspanins: Novel Molecular Regulators of Gastric Cancer EGF EGFR CD151 TSPAN8 TSPAN4 PMC6482252__F2 The physiological generation and function of lipid mediators in immunity TES ACOX1 LTA COX1 PMC6482252__F1 Mechanism of foam cell formation ABCG1 ACAT1 CD36 LDLR ABCA1 IL1B PMC4865504__F1 Human and rodent adrenal steroidogenic pathways HSD3B2 STAR CYP11B2 LDLR PMC2856637__F1 Simplified scheme of early FcERI-mediated signaling events SNAP23 SYK BTK FYN BCL10 STIM1 LYN GRB2 GAB2 PMC3508169__F2 Known relationships between the candidate genes FASN HEL-S-28 IRS4 SLC8A1 ITGAV PRKCB CD109 INSR TLR4 PRKCA ITGA6 PTPRE ADAM10 SRC PMC11008418__F8 Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis SLC3A2 GSDMD GPX4 SLC7A11 SIRT1 PMC9016198__F1 Long COVID: The Nature of Thrombotic Sequelae Determines the Necessity of Early Anticoagulation TF TMPRSS2 ACE2 PMC7962940__F7 Role of miR-548m in regulating EMT in breast cancer SNAI2 AHR MMP9 PMC7376987__F2 Summary of recent advancement toward heart regeneration CXCL12 CXCR4 PITX2 PMC10535706__F8 Akkermansia muciniphila inhibits tryptophan metabolism via the AhR/Beta-catenin signaling pathway to counter the progression of colorectal cancer TPH1 ID2 AHR CTNNB1 PMC7312731__F1 Differential activation of downstream molecules of the insulin-like growth factor (IGF) signaling network STAT3 BAD IGF1 PXN SOCS3 GRB2 FOS IRS1 PMC3924581__F1 AEG-1/MTDH/LYRIC promotes hepatocarcinogenesis IGFBP7 MMP9 SND1 CTNNB1 PMC3028977__F6 CD36 contributes to inflammation and impaired insulin signalling in adipocytes and macrophages FYN CD36 LYN PMC6434857__F2 Possible therapeutic implications of resveratrol/metformin/exercise in cognition through osteocalcin signalling GPR158 BDNF SIRT1 PMC3414724__F2 Role of the PI3K pathway in B cell antigen presentation functions BTK BCR PI3 PMC3414724__F1 Major components of the PI3K pathway in B cells discussed in this review SYK BCR PI3 CD19 PTEN LYN PMC3414724__F4 Alterations in the PI3K pathway in malignant B cells SYK BCR PI3 CD19 PTEN PMC9120413__F7 Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome NLRP3 ANXA1 IL1B MYD88 PMC7000863__F1 Unfolded protein response (UPR) pathway ATF4 MTOR EIF2A PMC7973386__F1 Representation of NAD+biosynthesis pathways SIRT3 SIRT7 NAPRT SIRT4 SIRT5 NAMPT SIRT1 NMNAT3 SIRT6 PMC4454471__F3 Model for generation of repeat expansions during MMR and BER MSH2 MSH3 FEN1 PCNA WRN PMC5062167__F8 Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model PTMS PMC7016612__F3 Crosstalk between primordial follicle activation and DDR pathway RPS6 TSC2 RAD51 TSC1 BRCA1 FOXO3A BRCA2 KL KIT ATM PTEN PMC7278809__F1 NAD+ biosynthesis pathways PNP NAPRT NAMPT PMC7016612__F5 Molecular relationship between phosphoinositide 3-kinase/protein kinase (PTEN/Akt) activation, DNA damage and decreased ovarian reserve BAX H2AX ATM PTEN AMH PMC8982613__F6 Infantile hepatic hemangiomas: looking backwards and forwards HEL-S-133P HK2 PTEN MTOR PMC4576203__F2 Participation of HPV oncogenes at different levels of Wnt/Beta-catenin cell signaling regulation FOXM1 SIAH1 APC NKX2-1 GSK3B CTNNB1 MZF1 PMC4576203__F1 Wnt/Beta-catenin cell signaling pathway FOXM1 APC CTNNB1 PMC8833126__F9 Novel pyroptosis-related signature predicts prognosis and response to treatment in breast carcinoma NLRP3 FOXO3A FGF21 GSDMC IL18 IL36G IRF3 DFNA5 IL36B GBP1 GJA1 PMC5056258__F1 PI3K/AKT/mTOR pathway is a critical pro-survival cell signaling pathway within NETs that mediates cell growth and peptide translation TSC2 TSC1 PTEN MTOR PMC10308444__F5 Integrated transcriptome and microRNA sequencing analyses reveal gene responses in poplar leaves infected by the novel pathogen bean common mosaic virus (BCMV) PDC PC KIT PMC10884126__F8 Interaction networks of “pathways-differentially expressed lncRNAs-target genes” PPP1R1B COL1A1 FOSL1 EGFL6 PGLYRP4 SPINK6 CD14 SIX4 COL6A5 COL3A1 PMC5071376__F2 Diagrammatic representation of the integration of leptin and insulin signals in the regulation of energy homeostasis in the central nervous system STAT3 POMC NPY PMC5896366__F2 EGF receptor (EGFR) effects on ABC transporters EGF EGFR PTEN ABCG2 ABCB1 PMC6948191__F3 Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies CGAS MAVS TLR3 INA TLR9 TLR8 AIM2 IRF3 IRF7 TLR7 CDK4 MYD88 PMC5477576__F4 Intrinsic apoptosis pathway BAX BAD EIF2A TRAF2 PMC5477576__F3 Extrinsic apoptosis pathway FAS TRADD TAB3 FADD PMC7379086__F2 Regulatory Effects of O-GlcNAcylation in Vascular Smooth Muscle Cells on Diabetic Vasculopathy OGA OGT RUNX2 PMC3104927__F6 RHIM-dependent signaling TBK1 TLR3 TLR4 RELA IRF3 PMC9411667__F3 Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis STAT3 HMOX1 STAT1 BACH1 NLRP3 KEAP1 JAK3 MTOR JAK1 TRAF6 MYD88 PMC9411667__F2 Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis STAT3 STAT1 NLRP3 MAL JAK3 SMAD6 SMAD4 MTOR JAK1 TRAF6 NOTCH1 MYD88 PMC9574357__F2 IgA vasculitis update: Epidemiology, pathogenesis, and biomarkers CA3 GAL LIF TLR9 TLR7 HEL-S-11 MYD88 PMC3922145__F3 Differential expression of mTOR and HIF-1A pathways between leiomyoma, HLRCC and leiomyosarcoma RHEB TSC2 EGR1 TSC1 MTOR PMC8196684__F1 Methylation Patterns of DKK1, DKK3 and GSK3B Are Accompanied with Different Expression Levels in Human Astrocytoma APC GSK3B LRP5 LRP6 CTNNB1 PMC10929826__F8 MUC1 promotes RIF by regulating macrophage ROS-SHP2 signaling pathway to up-regulate inflammatory response and inhibit angiogenesis IFNG TBK1 MUC1 HIF1A MTOR PMC8085163__F1 Isoprenoid biosynthetic pathway IPP RAP1A FDPS PMC8237035__F1 SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19 TH CLU PDC PMC3091670__F3 Complement pathway MASP1 C6 CD59 C7 MASP2 C2 C1S CR2 C4B_2 CR1 PMC3091670__F2 Interferon signalling cascade NOS2 STAT2 PSMB8 IRF9 IFIT1 IFITM1 IFIT3 IRF1 STAT1 MX2 MX1 TAP2 TYK2 OAS2 PMC4838842__F7 Resveratrol enhances HBV replication through activating Sirt1-PGC-1Alpha-PPARA pathway NR1C1 SIRT1 CP PMC10523328__F2 Tactile twist: decoding the phenomena of mechanical itch and alloknesis GRPR PIEZO1 ITCH PIEZO2 FOXP2 UCN3 NPY NPPB CALCR PMC4062953__F2 Classical and non-classical pathways of androgen biosynthesis HSD17B3 CYP17A1 HSD17B10 AKR1C1 UGT2B7 UGT2B17 STS DIO1 UGT2B15 HSD17B6 SULT2B1 CYP11A1 HSD17B2 RDH5 AKR1C2 CYP7B1 PMC7835009__F6 VEGFR1-specific signaling pathway that HIF1A participates in NCK1 NRP2 PTPN11 HIF1A SHC2 VEGFA MAPK3 VEGFB CBL PLCG1 PDPK1 CD2AP CALM1 PMC4062953__F1 Steroid hormone synthesis pathways in the adrenal gland and testis HSD3B2 HSD17B3 STAR CYP17A1 CYP11B2 CYP11A1 HSD11B2 HSD11B1 STS PMC7774019__F8 EBV early protein BFRF1 inhibiting RLR-mediated IFNB signaling pathway TBK1 IRF3 TRAF3 PMC9599947__F2 STAT3 Inhibitors: A Novel Insight for Anticancer Therapy of Pancreatic Cancer STAT3 EGFR ZNF596 PMC6722688__F1 A simplified diagram of the metabolic fate of maternal dietary choline and its delivery to the developing fetus PEMT PC PEX3 PMC9243343__F2 Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy ROCK1 MTOR PMC4114106__F2 Ubiquitination of RIP1 is an early pro-survival checkpoint in TNF signaling TRADD TAB3 CASP3 FADD PMC8505648__F4 Targeted therapy of BCBM treatment CDK6 MTOR VEGFA CDK4 PMC4034039__F5 Proposed lignin degradation pathway in C TH C2 H1-6 PMC6278600__F1 Postulated cellular mechanisms of 20-HETE bioactions in the blood vessel wall EGFR GPR75 IL6 ARHA EIF4E PMC5392205__F10 Atorvastatin inhibits the immediate-early response gene EGR1 and improves the functional pro of CD4+T-lymphocytes in acute coronary syndromes IL10 EGR1 TLR4 CCR2 FOS MYD88 PMC12175327__F1 Neutrophils interact with CTCs through both direct and indirect mechanisms CXCL1 SIRPA VCAM1 CD47 PMC11032202__F6 Intratumoural heterogeneity informs intertumoural heterogeneity HIF1A NLGN3 VHL PMC11032202__F3 Oncogenes versus tumour suppressor genes in glioblastoma RB1 PIK3CA CDKN2A NF1 EGFR PTEN MYC PMC12175327__F4 Nanomaterials for driving neutrophil repolarization toward the N1 phenotype, degrading ENTs and modulating neutrophil infiltration LTB NPS CGAS COIL IRF3 MMP9 PMC3499024__F2 Bone anabolism regulated by statins BMP2 RHO RUNX2 PMC5140697__F1 Targeting cancer metabolism: dietary and pharmacological interventions ACLY GLS HEL-S-133P PHGDH FASN HIF1A MTOR MYC KRAS PSPH PMC4965903__F1 IL-7RA pathway mutations provide potential targets for acute lymphoblastic leukemia therapy TSLP PTEN MTOR PMC5140697__F2 Targeting cancer metabolism: dietary and pharmacological interventions IGF1 EGFR IGF1R MTOR PMC4673467__F2 Wnt signaling pathways APC RHO CTNNB1 PMC9382782__F2 Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation IL33 CCL2 PMC7612338__F1 ISR signaling pathway DELE1 ELF2 OMA1 ATF4 EIF2A IMPACT PMC8505648__F3 Interactions between cancer cells and resident cells STAT1 FAS EGFR BCL2 PTEN GSTA5 MYC PMC8613896__F2 New perspectives on the treatment of hidradenitis suppurativa CXCL11 NLRP3 CXCL1 CXCL6 CCL2 TNF CXCL8 CCL20 PMC6886244__F1 Scheme of the N-linked glycosylation pathway GMPPB NANP CAD ALG11 FPGT ALG2 GMDS CMAS MNS1 NANS ALG5 ALG12 DOLK GNE PGM3 ALG13 NGLY1 PMC7016612__F2 DNA double-strand breaks (DSBs) response pathway CDC2 RAD51 DMC1 BRCA2 CDK2 BCL2 ATM MDC1 CDK4 PMC3370283__F2 Somatic Activating PIK3CA Mutations in CLOVES Syndrome(A) Demonstration of the PIK3CA c.1624G>A somatic mosaic mutation in participant CL4 PIK3CA PTEN MTOR PMC10990851__F9 Integrated transcriptomic and metabolomic analysis reveals the regulation mechanism of early bolting and flowering in two cultivars of Angelica sinensis RFWD2 PRR9 PRR7 ELF3 PMC10990851__F8 Metabolic pathway map of biosynthesis related to photosynthesis BAD PC FES PMC10148099__F7 Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease EHHADH HMGCL ACSF3 IDH3B PCCA DBT PCCB CS MCEE ACSS2 ABAT SUCLG1 BCAT2 HEL-S-32 MDH2 AOX1 FH ACO2 ACADS FASN ACSS3 ACOT12 SDHA SDHB DLAT PDK4 OGDH SUCLG2 BCAT1 DLD MB PMC3006139__F6 Subversion of Innate Defenses by the Interplay between DENV and Pre-Existing Enhancing Antibodies: TLRs Signaling Collapse TIRAP TLR3 TLR4 NFKBIE TANK IRAK1 IRF7 TLR7 IRAK4 MYD88 PMC8046925__F6 Visual pigment cycle reactions in vertebrate and invertebrate photoreceptors: (A) Pathways for visual pigment regeneration in the vertebrate retina, including both the classical and non-classical pathways RPE LRAT RGR PMC8511580__F1 Biological signaling networks related to PM10 & PM2.5 exposure inducing skin-related cellular processes and diseases KLF4 PPARG TNC HEL113 TIMP1 HMGA2 CXCL5 EGFR CCL2 CSF3 MPO GNAS INHBA SOX9 FST BMP4 CHUK PROC CREB1 FGFBP1 JUP THBS1 JUN CSF2 EGR1 NR1H3 SCD KRT14 PDGFA LIF CXCL2 MIF VEGFA CXCL10 FGF2 NR2A1 RELA EDN1 BMP2 CCL4 BMP5 AKAP12 CCL20 TRAF2 PMC4905302__F1 Autophagy regulatory pathway ATG10 ATG3 ATG12 ATG14 ATG5 PMC3721080__F6 Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks POR PRKCE C2 RS1 MTOR PRCD TNF PMC4811737__F1 Cellular and molecular mechanisms implicated in regulating the balance between tolerance and rejection in the mouse liver transplant model IFNG CD80 FAS PMC5460589__F2 The folate biosynthesis pathway and its compartmentalisation in plants (modified from ) DHFR FPGS DHPS PMC2710681__F4 Model describing TLS across CPD in human cells POLM POLK POLG PMC2773638__F4 Coordination of extracellular and intracellular signaling regulates cytoskeletal dynamics and axon formation CDC42 APC GSK3B ARHA BDNF RAC1 PMC5112569__F6 Regulation of Sirt1/Nrf2/TNFA signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity KIF9 TRADD KEAP1 MTOR SIRT1 PMC4736967__F1 Wnt/Beta-catenin signaling in ASDs TSC2 TSC1 APC LRP5 LRP6 PMC5540363__F1 Oxygen regulation of ESC metabolism and epigenetic landscape GNE GC SOX2 PMC2684849__F3 Transcriptional regulation of human small nuclear RNA genes TXN BRF2 TBP BDP1 PMC11703929__F1 Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis TBK1 CGAS IRF3 PMC5082570__F1 Mammalian choline degradation pathway with DMGDH as metabolic branch point BAD HEL-S-182mP PIPOX PMC8450567__F5 Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy SDHD CYB PMC4941269__F4 Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer CRK BAD SNAI1 ARHA ID1 PMC8546664__F2 Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy IFNG ATR CGAS ATM IRF3 PMC8546664__F1 Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy SSBP3 POLD3 RFC4 MPG RFC2 NEIL2 PMS2 DNTT NEIL3 PNKP MUTYH RPA3 UNG PARP2 POLD4 POLE POLD2 MBD4 TDG MGMT POLL MSH6 POLM RAD50 CETN2 MSH2 GTF2H5 POLE2 MSH3 GTF2H2C_2 NBN XPC DDB2 BARD1 MLH3 POLE4 CUL4A POLR2B MRE11A BRCA1 POLE3 RPA4 RAD9B XPA ATR PARP4 ERCC2 PCNA BRCA2 BLM CCNH CDK7 ATM WRN RPA1 PRKDC PARP3 RFC3 SLX4 APEX2 GTF2H2 GTF2H3 PMC7789510__F6 Simplified schema and functions of SAUR genes in plant evolution MAX TH ARF6 PMC9604794__F15 Network Pharmacological Analysis of the Red Sea Sponge Hyrtios erectus Extract to Reveal Anticancer Efficacy of Corresponding Loaded Niosomes MOS TUB DAP PMC3214273__F1 Pathogenic microbes and community service through manipulation of innate immunity CA3 TLR1 TLR4 GSK3B CXCR4 PMC7606465__F7 Next-generation sequencing analysis of circulating micro-RNA expression in response to parabolic flight as a spaceflight analogue CDK2 ATM MDM2 CDK4 PMC6050486__F5 Schematic drawing of epigenetic reprogramming in Dnmts, Sfrp4 and Wnt/B‐catenin pathway from the foetus to offspring SFRP4 FOSL1 APC GSK3B LRP5 HIF1A PMC7541692__F1 Dysregulation of the mitogen-activated protein kinase (MAPK) signaling pathway in melanoma NF1 BRAF NRAS PMC7586430__F2 Regulation and functions of NEDD4 E3 ligases in cardiac disease WWP1 SMAD1 TGFB1 DKFZp781O1323 ITCH TXNIP EZH2 YBX1 CCNA2 CCNB1 SMURF2 PMC9162043__F7 Receptor for activated C kinase 1 promotes cervical cancer lymph node metastasis via the glycolysis-dependent AKT/mTOR signaling POU2F2 HEL-S-133P HK2 IGF1R MTOR PMC7586430__F1 Ubiquitination-proteasome of NEDD4 E3 ligases pathway WWP1 NEDD4 ITCH PMC3919808__F9 Pathophysiology of Acute Kidney Injury HTRA2 FAS DIABLO FADD PMC7586430__F3 Regulation and functions of NEDD4 E3 ligases in vascular disease SEPTIN4 TGFB1 SMURF1 BMP2 TGFBR3 SMURF2 RUNX2 PMC6159944__F9 Schematic pathway representing findings of this study ABCG1 FAS LOX CES1 CD36 CYP27A1 ABCA1 PMC6834859__F1 Effect of GPCRs on RTK transactivation EGFR MTOR SRC PMC5866970__F2 Regulation of the Hippo pathway in endothelial cells ANKRD1 VCAM1 RHO PMC5653513__F2 PD1-dependent inhibitory mechanisms ZAP70 ITCH CDK2 PTEN PMC5866970__F1 Components of the Hippo/YAP pathway LATS1 LATS2 PMC7937835__F3 Lessons from mitochondrial proteostasis in adipose tissue ATF5 GDF15 ATF4 PMC9138536__F2 Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence ZAP70 WIPF3 MILR1 OSM CTSS CXCL3 DOCK2 SHC4 TNFRSF13C TLR4 GC COL4A1 CCR1 IL10 ANXA2 CFH BLNK CXCL2 TNF CXCL10 SEMA4D RCSD1 PRKCQ CDK2 GRB2 TMEM106A PMC5866970__F3 Regulation of the Hippo pathway in smooth muscle cells CYR61 RHO MYC CCND1 PMC2586935__F4 TGFB pathway as affected by IGF2 administration based on Pathway-Express SMAD1 THBS1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 NODAL ARHA TNF PITX2 TGFBR1 IFNG RBX1 SMURF1 E2F4 FST ROCK1 SKP1 SMURF2 PMC5889571__F2 CD109 and TGFB signaling TF CD109 TGFBR2 SMAD2 SMAD4 PMC3562293__F2 Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities LPL LPA PC RHO MTOR RAC1 PMC8213678__F8 Discovery and function exploration of microRNA-155 as a molecular biomarker for early detection of breast cancer PRLR TH RAD1 GCK PMC7487321__F3 Oxygen-dependent pathway of plasmalogens biosynthesis in animals FAS FAR1 PC PMC2453072__F3 The relationship between dNTP pool levels and mutagenesis in an Escherichia coli NDP kinase mutant DCD UNG DUT PMC10573127__F3 Secretory cell (SC) differentiation programs KLF4 MCIDAS SFTPA1 PTGER3 SCNN1G GMNC IL13 FOXA3 SFTPD SPDEF RUNX2 SCGB1A1 SFTPB AGR2 CLCA1 MUC15 FOXM1 MUC5AC SCNN1B MYCL CFTR KLF5 FOXA2 AQP5 PMC10573127__F2 Molecular pathways involved in multiciliogenesis MCIDAS MYB RFX3 FOXJ1 CCNO MCC RFX2 E2F4 NOTCH1 PMC10573127__F1 Airway epithelial differentiation pathways TP73 KRT5 MYB RFX3 RFX2 DEUP1 KRT6C CDC20B KRT14 KRT16 SPDEF KRT23 KRT4 UGRP1 SCGB1A1 NGF MUC5AC CCNO FOXN4 MUC5B TP63 CFTR KRT13 PMC2676730__F5 The Pathway Less Traveled: Moving from Candidate Genes to Candidate Pathways in the Analysis of Genome-Wide Data from Large Scale Pharmacogenetic Association Studies DIO1 PMC5006437__F1 Regulation of molecules in the NMDAR signaling pathway on learning and memory ARC MAP2 BDNF PMC5799812__F6 A convergent model for the pathogenesis of ANKL TET2 IL10 MYC PMC6996369__F6 Scheme of predicted AJP001 signaling and the antibody production induced by the AJP001 conjugate peptide vaccine TH NLRP3 TLR4 IL1B PMC2959043__F3 Wnt/Beta-catenin signaling Ctenophore pathway APC LRP5 LRP6 CTNNB1 PMC2688747__F4 Fgf and Sdf-1 Pathways Interact during Zebrafish Fin Regeneration WNT5B FGFR1 WNT10A PMC9477422__F7 Ptprh mutant mouse tumors failing to dephosphorylate EGFR EGFR CDK2 PTPRH PMC7707548__F6 Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells H2AX GC DHODH MGMT PMC2724309__F2 Steroidogenesis pathway: Steroids are in bold; enzymes and cholesterol transport proteins are in italics STAR CYP11A1 PBR PMC8236385__F1 Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses MAP3K7IP1 TLR3 TAB3 MAL IRAK1 TLR7 TRAF6 LBP IRAK4 MYD88 PMC4063840__F2 In vivo gut transcriptome responses to Lactobacillus rhamnosus GG and Lactobacillus acidophilus in neonatal gnotobiotic piglets HMGB1 MAK TNF PMC6892982__F1 Autophagy regulators and functions associated with anti-aging effects NBR1 TSC2 TSC1 NUFIP1 TFEB BNIP3 PARK2 FUNDC1 PMC4002088__F7 Schematic representation of the proposed novel TXNIP/miR-124a/FOXA2/IAPP signaling pathway TXNIP FOXA2 IAPP PMC9287895__F3 Emerging strategies to overcome resistance to third-generation EGFR inhibitors STAT3 ROS1 ALK AXL EGFR NTRK1 PTEN GRB2 MTOR SRC MYC RET PMC3936199__F3 Iron homeostasis in the liver STAT3 CEBPA TFR2 EPOR EPO HFE TMPRSS6 HFE2 PMC5344902__F2 Type I interferon (IFN) signaling STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC5344902__F1 Pattern recognition receptor signaling that leads to the induction of type I interferons (IFNs) CSA2 TBK1 CGAS TRADD MAVS TLR9 IRAK1 IRF3 IRF7 TRAF6 MYD88 TLR3 TLR4 TLR8 TLR7 PMC5316308__F2 DREAM as a novel therapeutic target for anti-thrombotic agents TEC SYK BTK FYN PLCG2 LAT LYN SRC PMC12250001__F3 Principal microRNAs and targets involved in inflammation and cartilage destruction in OA BCL2L12 HBEGF SP1 ADAMTS5 MMP3 VCAM1 SIRT1 PMC6551314__F8 Proposed model for the role of Them2 in hepatic VLDL secretion LPA TG DGAT1 GPAT4 DGAT2 PMC2691965__F2 Toll-like receptor (TLR) activation TLR1 TIRAP TLR3 TLR4 CD14 TLR5 IRF3 TLR7 TRAF6 MYD88 PMC7880350__F8 Schematic illustration the contribution of FGF23 induced by post-infarct heart failure to promoting renal fibrosis FGFR4 GSK3B WAS CTNNB1 FGF23 PMC5497057__F2 Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer STK11 EGFR APC PTEN MTOR CTNNB1 RB1 TSC2 TSC1 CDK6 INSR NF1 PDGFRA ATM MDM2 BAK1 CDK4 PMC12250001__F2 Principal molecular mechanisms involved in the MAPK, NFKB, and PI3K/Akt signaling pathways activated by oxidative stress in OA ADAMTS5 KLF10 PTEN PMC11942346__F1 Mechanisms of adhesion formation: (1) Inhibition of fibrinolysis and ECM deposition PLG PMC9465188__F1 Recent advances in the therapeutic efficacy of hepatocyte growth factor gene‐modified mesenchymal stem cells in multiple disease settings S1PR1 BAX HGF VCAM1 FOXP3 CXCR4 PMC6767550__F2 Canonical and noncanonical signaling pathways of NOD1 and NOD2 TBK1 MAP3K7IP1 RIPK2 MAVS ATG16L1 NOD2 IRF3 NOD1 PMC8606592__F1 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer TUG1 PMC6986015__F9 Schematic depiction of main conclusions CASP8 CASP3 ATF4 PMC3648641__F1 Unraveling Mechanisms Regulating Systemic Iron Homeostasis BMP6 TFR2 SMAD4 HFE TMPRSS6 HFE2 PMC4661576__F1 The fate of chemoresistance in triple negative breast cancer (TNBC) BAX MSH2 ABCG2 PMC6981617__F2 General metabolism and elemental sulfur-mediated cellular responses in Palaeococcus pacificus DY20341T POR APRT PGP FES HEL-S-11 SHE PMC6180304__F2 Three key innate immune pathways for the most common retinal degenerative diseases SOCS1 STAT1 SIGLEC11 HEL-S-62p STAT2 IFNAR2 IRF9 IFNAR1 PBR SOCS3 JAK1 TYK2 PMC6743306__F6 Proposed model illustrating the roles of CHL1 during NPC carcinogenesis CDC42 CHL1 ARHA RAC1 PMC1899901__F6 A schematic model depicting the role of Artemis in the cellular response to IR CDC2 WEE1 ATM PLK1 PMC5003840__F1 Proposed biosynthetic pathway to the synthesis of xanthanolides GAA COCH PTS PMC9239773__F6 Identification of CXCR4 Upregulation in Diffuse Large B-Cell Lymphoma Associated with Prognostic Significance and Clinicopathological Characteristics CXCL12 SMAD4 PMC151822__F2 Signaling UPR-mediated cell death ATF4 TRAF2 PMC10177044__F2 Ratio of p38 signaling to ERK determines whether cancer cells enter a dormant state or undergo proliferation GDF10 HGF CXCL16 TGFBR3 MMP9 IGF2 LOXL2 LOX IGF1 DKK1 CX3CL1 BMP4 GREM1 MMP2 IL8RB CXCR4 PMC6736652__F1 Predictive biomarkers for bevacizumab efficacy in breast cancer AGTR1 MMP2 MVD MMP9 VEGFA PMC8465904__F4 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells BAX FAS APC GSK3B MDM2 CTNNB1 FADD PMC8465904__F3 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells BAX FAS APOF PMC9684870__F3 Disease-specific tissue glycosylation POMT1 APC CCL2 PMC8465904__F2 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells MMP7 EGF CSF2 CSF1 HGF PCNA EGFR APC GSK3B POLI MMP9 PDK2 TNF CSF3 CTNNB1 LATS1 CD44 LATS2 MMP2 BOK PMC9237610__F1 Genetic Manipulation of Biosynthetic Pathways in Mint HMGCR PGR PMC5407862__F1 Management of EGFR-mutated non-small-cell lung cancer: practical implications from a clinical and pathology perspective MAPK1 HGF EGFR BRAF PTEN MTOR PMC8465904__F1 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells CDC42 ALB APC GSK3B RYK RHO CTNNB1 PMC2423297__F9 The role of cAMP-stimulated adipogenesis via PKA- end Epac1-dependent processes IGF1 RHO GRB2 PMC9217905__F1 Molecular Pathogenesis of Sporadic Desmoid Tumours and Its Implications for Novel Therapies: A Systematised Narrative Review MMP7 COX2 APC CCND1 CTNNB1 PMC6367888__F6 Gene-pathway network of 26 DEGs IFIT3 OASL IFIT2 MX1 IL6 RSAD2 ISG15 GBP1 CXCL10 PMC3387493__F1 Dual Aspects of Altered Bone Remodeling in Psoriatic Arthritis SEMA4D BTK TNF RUNX2 PMC2910898__F1 During normoxia, HIF-1A is rapidly degraded by the ubiquitin-proteasome pathway HEL-S-133P EPO HIF1A PMC10380201__F7 Small-Extracellular-Vesicle-Derived miRNA Profile Identifies miR-483-3p and miR-326 as Regulators in the Pathogenesis of Antiphospholipid Syndrome (APS) TF CD80 F3 PTEN VCAM1 MTOR PMC6522926__F5 Schematic representation of the E2/ESR1/CD36/PPARA pathway in skeletal muscle cells TG CD36 FASN PMC9217905__F6 Molecular Pathogenesis of Sporadic Desmoid Tumours and Its Implications for Novel Therapies: A Systematised Narrative Review MMP7 COX2 APC CCND1 CTNNB1 PMC5902023__F1 Mammalian isoprenoid biosynthetic pathway with associated inhibitors IPP FDPS RHO PMC3091595__F2 Bcl-2 as an attractive target for modulating different modes of cell death in cancer therapy due to close communications with mediators of apoptosis, programmed necrosis, and autophagy BAX TRADD FADD PMC3947362__F7 The proposed model for the signaling events in mature, human oligodendrocytes in response to B. burgdorferi CCL5 CCL2 CXCL8 PMC8753521__F5 Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer RYR2 STAT3 OGT HMGB1 ADIPOR1 ADIPOR2 GCLM PTEN MTOR VEGFA MPC1 RHO RB1 GCLC NLK CXCR4 SIRT1 PMC9217541__F7 Study the Mechanism of Gualou Niubang Decoction in Treating Plasma Cell Mastitis Based on Network Pharmacology and Molecular Docking PPARG PGR SELE MVP IRF1 COL3A1 PMC8045279__F1 Leptin signaling pathways STAT3 POMC PC NPY SOCS3 GRB2 AgRP PMC9368893__F3 Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia BAX IGF1 MTOR IGF2 PMC7869230__F9 IL-17 signaling pathway cascades obtained from the global proteome data by KEGG pathway analysis USP25 IL17RC TRADD ELL MMP9 TNF TRAF6 CCL2 IL17D CD44 TRAF4 BOLL COX2 IL17RB CCL7 MMP3 TRAF2 FADD PMC9631787__F1 Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19 TGFBI SMAD2 ACE2 MPO MYD88 PMC2172900__F9 A model of how the Tor1/2 and Lst8 proteins affect amino acid biosynthesis and Gap1p sorting MKS1 HEL-S-26 PMC9631787__F3 Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19 CDH2 EGF TGFB1 SMAD2 MTOR TRAF6 ACE2 PMC4524397__F5 Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity TIGIT FGL2 FOXP3 PMC3119514__F3 IL-1 and TLR activation pathways TBK1 IL1R1 MAP3K7IP1 TIRAP TANK IRAK1 TRAF6 MYD88 PMC7710592__F1 Short-term heritable variation overwhelms two hundred generations of mutational variance for metabolic traits in Caenorhabditis elegans APRT ADK ADA PMC3119514__F2 TNFA and TCR activation pathways ZAP70 TRADD TRAF6 CARD14 PLCG1 MAP3K7IP1 BCL10 CARD10 TRAF5 TRAF2 CARD9 LCK FADD PMC6650964__F5A Proteomic Analysis of Morphologically Changed Tissues after Prolonged Dexamethasone Treatment DEK ATP2B2 HEL-S-271 HNRNPA2B1 AP2A2 PPP2CA ARL8B HEL-S-94n STX1A HEL-75 PMC3177043__F2 Different pathways of myostatin signalling IGF1 GSK3B MTOR CCND1 PMC3119514__F6 RNA polymerase II transcription complex SP1 TRAF1 PMC5266810__F1 Interorgan crosstalk involved in Beta-cell failure IL16 IAPP IL1B PMC8014382__F1 Tumor cell and T cells: the pathways that involve MDSC cells, CD8+ T cells, Tumor cells, NK cells and chemotherapy drugs were constructed APC KIT VEGFA RET PMC5054393__F7 Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells DUSP5 MAPK1 ST13 DUSP10 DUSP8 PIM1 STAT2 ZFYVE9 DUSP4 MTOR MAPK8 TGFBR1 MAPK3 STAT1 IFNGR2 EP300 DUSP16 PMC7212460__F2 Canonical Wnt/Beta-catenin pathway APC GSK3B CTNNB1 PMC4636403__F5 Investigation into the effects of antioxidant-rich extract of Tamarindus indica leaf on antioxidant enzyme activities, oxidative stress and gene expression profiles in HepG2 cells VWF SERPINF2 F5 DHCR24 PLG GSTM4 TFPI F2 F10 F3 A2M MX1 F8 F9 KNG1 CP PMC3129504__F2 Ras/Raf/mitogen-activated protein kinase pathway EGF EGFR BRAF GRB2 PMC8014382__F2 APC cells and T cells: the pathways that involve OX40/OX40L, PD-1/PD-L1, mTOR/Akt, NKKB/NFAT and Cyclin A/CDK were analyzed SIRT7 BATF APC IL4 BATF3 FOXP3 MTOR SIRT1 PMC6395653__F3 The metabolic network PALM MAL CIT PMC7912842__F1 Fibroblast growth factor-FGF receptor (FGF-FGFR) and cyclin D-cyclin-dependent kinase (CDK)4/6 pathways in breast cancer C6 PTX3 TSC2 CDK6 FRS2 CDK2 GRB2 MTOR CCND1 CDK4 CTNNB1 PMC3548172__F3 Cooperation of esBAF and PRC2 during pluripotency maintenance STAT3 LIF SOX2 PMC7407918__F3 Signaling pathways involved in exacerbating oxidative damage and liver injury EGR1 TRADD TLR4 CD14 IRAK1 TRAF6 NOX4 TRAF2 RAC1 IL1B MYD88 PMC8164580__F1 Neuronal dysfunction in HIV-associated neurocognitive disorders CXCL12 SRC CXCR4 RAC1 PMC4277124__F12 Proposed underlying mechanism for the effect of SCE on drug metabolizing enzymes and drug transporters via Nrf2-mediated signaling pathway GSTA4 KEAP1 GCLM NQO1 MAF PMC11003951__F8 Inflammatory Factor IL1A Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca2+/CaMK2b Pathway IL1A PMC8825588__F2 Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment TF BAX ATR LIMK1 APC ARF6 PTEN MTOR CTLA4 MYC C2 BCL2 ATM FADD PMC12222815__F7 GCRSZXD- Chinese herb - active ingredient - hub gene - signaling pathway – disease network EGFR GC SRC PMC8825588__F5 Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment TLR4 NRP1 MSC PMC4367656__F1 Physiological changes with aging () IGF1 PTEN MTOR SIRT1 PMC8164580__F2 Neuronal dysfunction in HIV-associated neurocognitive disorders MDM2 SRC IL1B PMC4592361__F7 Involvement of LRP6 in the PTH-stimulated anabolic bone effect SOST LRP6 PTH CTNNB1 PMC8072315__F1 Major signaling pathways and key mediators of macrophages in acute kidney injury STAT3 SYK TLR4 JAK3 EPO PTEN MTOR PMC7059563__F4 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.A KEGG pathway analysis revealed 15 substantially enriched pathways corresponding to transcripts dysregulated after spinal cord injury (SCI) TRADD LIF CASP3 IL6 TNF PMC4278302__F6 Acellular fraction of ovarian cancer ascites induce apoptosis by activating JNK and inducing BRCA1, Fas and FasL expression in ovarian cancer cells FAS BRCA1 HEL-S-162eP PMC8566438__F1 Where the Aryl Hydrocarbon Receptor Meets the microRNAs: Literature Review of the Last 10 Years AIP AHR AHRR SRC PMC9112604__F3 Endotheliitis, Shunts, and Ventilation–Perfusion Mismatch in Coronavirus Disease 2019: A Literature Review of Disease Mechanisms TMPRSS2 FURIN ACE2 PMC8083806__F2 An update on genetic basis of generalized pustular psoriasis (Review) AP1S3 CARD14 CXCL1 IL36RN CXCL2 CTSG TNF STEAP4 MPO MYD88 PMC2783576__F2 Mitotic removal of cohesin in humans: In humans, cohesins (pink) are removed from chromosome arms in prophase in a Plk1-dependent pathway APC SMC3 PLK1 PMC6523301__F1 Main cellular protein clearance mechanisms, the ubiquitin–proteasome system (UPS), and the autophagy pathway ATG10 ATG3 RPN2 ATG12 RPN1 ATG14 ATG5 PMC5823444__F8 Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen ChAT IL1B PMC3942890__F1 ER stress signaling pathway ATF4 EIF2A PMC9424857__F1 Entner-Doudoroff pathway in Synechocystis PCC 6803: Proposed regulatory roles and enzyme multifunctionalities HPR HEL-S-162eP PROC TNLG7C PMC11560437__F4 Aquaporins in sepsis- an update SP1 AQP3 AQP9 AQP1 PMC6498404__F4 High-affinity IgE is derived from the CD80+ pro-PC subset of IgG1 memory cells in mouse memory responses BACH2 FOXO1 GC PC BCL6 PMC5705153__F8 Cisplatin or LA-12 enhance killing effects of TRAIL in prostate cancer cells through Bid-dependent stimulation of mitochondrial apoptotic pathway but not caspase-10 FADD PMC5207552__F1 Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin–Beck disease BAX RASD1 BAD GSTT2 MCL1 IGFBP4 IGFBP2 BCL2L11 POSTN BCL2L1 CASP6 IGF1 HIPK2 BCL2 FZD1 CDC37 BAK1 BIK PMC11488446__F2 Alterations in the WNT/PCP Signalling Pathway During the Progression of OA DVL1 CELSR1 VANGL1 DVL3 DVL2 SCRIB FJX1 ARHA CELSR3 RAC1 DAAM1 PMC9025114__F3 Selectin-Mediated Signaling—Shedding Light on the Regulation of Integrin Activity in Neutrophils SYK BTK PLCG2 SCAP2 SRC RAC1 PMC8463915__F2 Diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation STAT3 EGF TLR4 EGFR PMC7205878__F2 Autophagy and microbial pathogenesis ATG16L1 ATG12 MLKL ADAM10 ATG5 PMC4986634__F7 Mechanism of hepatocarcinogenesis promotion via HBV-induced ROS accumulation STAT3 SOCS3 CCND1 PMC3527322__F1 Amniotic fluid stem cells to study mTOR signaling in differentiation RHEB MLST8 TSC2 RICTOR GRB10 TSC1 SGK1 ULK1 HIF1A MTOR DEPTOR IRS1 PMC8198588__F2 Cellular and Chemical Biology of Endocytic Trafficking and Intracellular Delivery—The GL–Lect Hypothesis GAL FUT1 ST8SIA5 ST8SIA1 GBGT1 ST3GAL1 B3GNT5 B4GALNT1 ST3GAL5 CER1 B4GALT5 B3GALT5 A4GALT ST6GALNAC4 PMC3726008__F5 Dose-dependent MeHg-induced gene expression alterations within the Wnt-signaling pathway ROCK2 CELSR1 CHD8 APC TBL1X GSK3B LRP5 LRP6 ARHA PSEN1 SFRP1 RBX1 CSNK1E BCAT1 SKP1 FZD1 CSNK1A1 TBL1XR1 LEF1 DAAM1 PMC8210554__F3 Circular RNAs as novel potential biomarkers for pancreatic cancer COL1A1 PMC5423134__F9 Proposed mechanism of action by the combination of VCP inhibitors and ER stress‐prolonging agent Salubrinal ATF4 EIF2A VCP PMC3586206__F1 Schematic summarizing the effects of MIF on the canonical MAPK pathways CD74 MIF CXCR4 PMC7011147__F2 Interactions between cells in the tumour microenvironment EGF PMC3289531__F2 A, Hepatic BCAA metabolism LPL TG FAS HEL-S-62p CS MTOR HEL-S-70p IRS1 PMC5938061__F7 Gastrin-CCKBR–GA12/13–RhoA–ROCK signaling in pancreatic cancer CCKBR FAS HEL-S-11 PMC12033294__F7 MAPK signalling pathway (KEGG:04,010, 31 counts; https://www MAX ECSIT EGF FAS CD14 TNF FLNA MEF2C MPL NF1 NLK GRB2 MIP PMC8406585__F10 TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage GSDMD NLRP3 IL1B PMC12033294__F8 cAMP signalling pathway (KEGG:04,024, 7 counts; https://www OXT VIP GAL CFTR GIP NPY PMC7555106__F3 MDSC-mediated events in intestinal epithelial dysplasia S1PR1 S100A8 MYC CTNNB1 PMC3458425__F6 Docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and 16O/18O labeling EGR1 CDK5 SV2B YY1 CREB1 PMC8243426__F1 Phase II study of the PI3K inhibitor copanlisib in combination with the anti-CD20 monoclonal antibody rituximab for patients with marginal zone lymphoma: treatment rationale and protocol design of the COUP-1 trial SYK BTK BCR LYN MTOR PMC3861642__F9 Genes in the insulin signaling KEGG pathway that are directly or indirectly regulated by EBF1 SOCS1 PIK3CA RAF1 PIK3CD PIK3R1 FLOT2 SOCS3 PRKAA1 HEL-S-42 PRKAR1A PYGB HK2 FLOT1 IRS1 EIF4E HRAS RHEB CRK ACACB TSC2 TSC1 FBP2 SOS2 PRKAG1 PRKAB2 PRKAB1 GRB2 PHKA1 BAD FAS PIK3R5 PPP1CC PIK3R3 AKT3 PRKAG2 PHKA2 PDK2 MTOR INS SHC4 HEL-S-80p INSR PFKM PHKG2 SOCS4 IRS4 KRAS ARAF PFKP GYS1 FBP1 PRKAA2 PMC7004076__F4 Molecular mechanisms of YQCT RARA TLR3 C2 MTOR FGF10 FGFR2 PMC8659262__F1 Co-Production of Isoprene and Lactate by Engineered Escherichia coli in Microaerobic Conditions IPP MVD MVK PMC7799400__F1 COVID-19 pathogenesis and MSCs role in the elimination of SARS-CoV-2 related complications (1) SARS-CoV-2 enters alveolar type II cells through binding ACE2 HGF IGF1 MSC CFTR ACE2 PMC6367542__F6 Proposed mechanisms of adiponectin-induced growth inhibition of pancreatic cancer TCF7L2 ADIPOR1 ADIPOR2 GSK3B CTNNB1 PMC1603434__F6 TSC1/TSC2 in the canonical Beta-catenin signaling pathway FRAT1 TSC2 CTNNB1 PMC6302460__F3 Comparison of four TPs in breast cancer subtypes TSC2 BAD TSC1 RXRA GRB2 PMC4783948__F5 Highest-scoring and fifth highest-scoring pathway maps for the last two time points post-TBI (24 and 72 h) CDC42 STAT3 ATR GSK3B ATF2 RHO CCNA2 SKP2 PLK1 CDK6 RALA TOB1 PDPK1 ATM MDM2 CCND1 CDK4 CDC2 ROCK2 LIMK2 CDC34 HRAS RBX1 PAK1 RELA SKP1 CDK2 PMC4075129__F3 Molecular targets based on the predominant PI3K/AKT/GSK-3B pathway GSK3B BDNF CTNNB1 PMC4075129__F1 PI3K/AKT/GSK-3B signaling pathway in neuronal cells of Alzheimer’s disease CDK5 GSK3B BDNF PMC3573419__F1 Germinal-center B-cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) derived from normal germinal-center centroblasts BCL2 PTEN MDM2 MTOR ING1 PMC4137950__F1 Human respriatory syncytial virus (hRSV) recognition by airways epithelial cells: upon infection, different hRSV components activate pattern recognition receptors (PRRs) MAVS TLR3 TLR4 NOD2 CD14 IRF3 TLR7 CCL5 CXCL10 IL1B MYD88 PMC7655645__F3 Protein interactions associated with signaling pathways enriched in diabetes mellitus-associated coronary heart disease ZAP70 ATXN10 RBM4B GLS CACNA2D2 NKG7 CDCA4 INA CCDC107 TSEN54 NUDCD3 RAB11FIP5 PVRIG GNGT2 WDR54 DUSP2 ZDHHC14 DCP1B B3GAT1 GNAS GZMH PCNT RTKN CTSF COPS6 DAG1 CTSW KCNE4 PDZD4 C1QTNF6 PTRH1 DMAP1 PMPCA ZNF76 PMC2727431__F1 Various states of pluripotency KLF4 LIF SOX2 PMC4524600__F6 Comparative Transcriptome Analysis of Differentially Expressed Genes and Signaling Pathways between XY and YY Testis in Yellow Catfish GRPR PRLR LTB4R MLNR KISS1 OXTR SSTR2 GHR CALCR BDKRB2 PMC6277997__F6 Mechanisms of DMTN in the invasion and metastasis of CRC DMTN PAK1 ARHGEF2 RAC1 PMC4524600__F5 Comparative Transcriptome Analysis of Differentially Expressed Genes and Signaling Pathways between XY and YY Testis in Yellow Catfish SYK BCR TLR4 CD19 PTEN CDC37 KITLG RAC1 CSF1R PMC4414328__F8 We propose three possible pathways that could lead to liver NKT cell anergy WNT3A GSK3B CTNNB1 PMC3573419__F2 Activated B-cell-like (ABC) diffuse large B-cell lymphomas (DLBCLs) are derived from plasmablasts that are characterized by a block in differentiation STAT3 SYK CD79B CD79A PRDM1 CARD11 NFATC1 MTOR MYD88 BTK BCR SPIB BCL2 BCL6 PMC8159877__F4 Changes associated with IMR in the anterior leaflets at 4 weeks post-MI within the TGFB signaling pathway BAMBI IFNG SMAD1 MAP3K7IP1 DKFZp781O1323 ID2 SMAD2 SMAD6 SMAD4 ARHA TRAF6 TGFBR1 PMC4720912__F2 Insulin signaling pathway RHEB TSC2 BAD TSC1 INSR GRB2 PMC4945843__F1 Major cholesterol metabolism pathways in the liver ABCG1 HMGCR CYP7A1 FASN LDLR ABCA1 PMC9444456__F2 Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain CXCL1 PBR IL8RB BDNF TNF PMC11641026__F4 Biosynthesis of aminonucleosides CSTB CSTA PMC4325931__F6 Overlay of gene expression on the p53 signaling pathway BAX FAS PERP SFN PIGS MDM2 APAF1 CDK4 PMC5088662__F5 Schematic diagram elucidating signalling pathway of TLR4 and TLR9 responsible for GFNs-induced cytotoxicity TLR4 TLR9 TRAF6 IL1B MYD88 PMC8549894__F2 Pathophysiology of Exercise-Induced Muscle Damage and Its Structural, Functional, Metabolic, and Clinical Consequences RAC1 PIKFYVE PMC5350147__F1 Akt/mTOR signaling schematic RPS6 TSC2 TSC1 NF1 PTEN MTOR IRS1 EIF4E PMC9314012__F2 Periodontitis, chronic liver diseases, and the emerging oral‐gut‐liver axis TGFBR2 TLR4 IRS1 IL1B MYD88 PMC6617469__F4 Expressional change of genes for the central carbon metabolic network in Kmmig1 GPD2 ADH6 RAG2 MDH2 ACAD11 PMC3540890__F1 Biosynthetic pathway of prostaglandins COX1 COX2 GHB2 PMC5335622__F2 Theoretical concept of combined application of checkpoint blockade therapy and DGK-inhibition ZAP70 IFNG LCK PMC3084054__F1 Synthesis-enabled functional group deletions to probe predicted intermolecular interactions involving the C41 carboxylic acid and/or the C19 mycosamine appendages of AmB TES NAT2 LBH PMC3822825__F2 E2F1-induced apoptosis ATR ATM MDM2 APAF1 PMC6885770__F1 Nrf2/HO-1 pathway RBX1 KEAP1 MAF PMC8843872__F1 Ferroptosis: An emerging therapeutic opportunity for cancer SLC3A2 GPX4 LPCAT3 FACL4 SLC7A11 PMC5088662__F4 MAPKs, TGF-beta and TNFA dependent pathways involved in GFNs toxicity BAX SMAD2 SMAD4 TNF PMC4925704__F2 Anti-Cancer Properties of the Naturally Occurring Aphrodisiacs: Icariin and Its Derivatives STAT3 FAS EGFR CTNNB1 FADD PMC3069932__F9 Proposed role of Nodal in human placental development and mechanism of Nodal-regulated trophoblast invasion SMAD2 MMP2 NODAL PMC3836323__F2 Vascular smooth muscle cells mechanotransduction mechanisms in stretch-dependent interconnected signalling IGF1 ARHA RAC1 PMC4268999__F2 PI3K/Akt signalling pathway TSC2 BAD BCL2 PTEN MDM2 MTOR PMC4268999__F1 Wnt/Beta-catenin pathway APC GSK3B LRP6 MYC TEF CTNNB1 PMC10958678__F7 P53 and mut‐p53 in the TME during cancer development ISG15 ULBP2 PMC4461458__F2 Prevalent mutations in acute myeloid leukemia (AML) potentially affect HIF levels in cancer cells HIF1A MDM2 MTOR VHL PMC10958678__F6 Functional activities of mut‐p53 in cancers CXCL12 PCNA EGFR SMAD2 PML PTEN SLC7A11 TCF4 FOXH1 E2F4 SLC25A1 ATF4 GPR49 MAP2K3 NR1i1 TOPBP1 ETS2 DICER1 SOX2 ARHA CD44 CCNE2 TK1 MAFF BTG2 BRCA1 FOXO1 CASP3 KLF17 PMC6682527__F4 KLF5-targeted genes in the pancreatic cancer pathway STAT3 BAX EGF BAD TGFA RAD51 E2F2 EGFR SMAD2 BRCA2 SMAD4 MTOR POLK E2F3 KLF5 JAK1 RALBP1 PMC9514046__F2 Interleukin 22 and its association with neurodegenerative disease activity CXCR3 LIF CCR6 PDC CCR4 CCR10 PMC8685420__F3 Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer JUN THBS1 TGFBI PLAUR VEGFA ANGPT2 FOS ITGAV CDKN2A ITGAM CDKN1A NFKB1 ERBB2 BCL2 MDM2 PMC5987683__F3 Mitogen-activated protein kinase signalling pathway ECSIT CSA2 EGF JUN FAS BRAF CD14 ATF2 TNF MYC TRAF6 FOS MEF2C NGF MAP3K7IP1 MOS NFKB1 HEL-S-102 ATF4 NLK TRAF2 PMC7526126__F3 InterferonG mediated cancer regression SLC3A2 CASP9 CASP8 CASP3 EN1 SLC7A11 HIF1A VEGFA PMC7399975__F6 Tec kinase signaling and FAT10 pathway GNG2 TEC SYK BTK FOXO3A SRC FADD PMC7526126__F1 InterferonG signaling STAT1 IRF1 MTOR JAK1 PMC8557551__F6 Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy CYP27B1 COL1A1 RUNX2 PMC3179548__F2 PE intoxication pathway CD22 EEF2 LRP1B FURIN PMC8909190__F2 Transcriptomics Reveals Discordant Lipid Metabolism Effects between In Vitro Models Exposed to Elafibranor and Liver Samples of NAFLD Patients after Bariatric Surgery IDE GAL TARP APP PMC7748976__F1 Interaction of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus with the renin-angiotensin system and phagocyte activation cascade TNF ACE2 PMC4811771__F16 SLE risk haplotype upregulates the antigen presentation pathway (APP) ZNF143 B9D2 TRIM56 CUEDC2 AOAH C2 RNF114 RPS6KA1 DKFZp666G145 SQSTM1 IRF4 PMC9249764__F4 Effect of VEN incubation on gene expression of apoptotic signaling cascades in SEM (upper panel) and RS4;11 cells (lower panel) HELLS BAD LTA FAS TRADD BOC MCL1 CYCS IGF1R TNFRSF25 PMAIP1 MYC IKBKG TNFRSF18 BCL2L1 BCL2L2 MAP2K4 NFKBIE BOK CHUK MDM2 TNFRSF21 BAX CASP2 IRF3 IRF7 IRF4 TNF BCL2L11 IGF2 MAP3K1 NFKB1 RELA IKBKB IRF2 NFKBIA BCL2 TNFSF10 BIRC2 TRAF2 DIABLO FADD PMC8609049__F1 “Aerobic glycolytic imaging” of human gliomas using combined pH-, oxygen-, and perfusion-weighted magnetic resonance imaging GLS HEL-S-133P LAT HK2 MTOR MTR PMC2600878__F6 Syk signaling is necessary for E-selectin-induced LFA-1-ICAM-1 association and rolling but not arrest SYK CXCL1 IL8RB PMC2843172__F8 Schematic drawing summarizing the signaling pathway downstream from CB1 receptors in cerebellar granule cell precursors GSK3B CCND1 CTNNB1 PMC12121766__F2 Sites of activity of genes encoded by SNPs observed to be associated in our study in the NO signaling pathway downstream of Cit ADCY8 PDE9A PRMT6 KCNMB4 PMC4963810__F2 Comparison of the Drosophila and vertebrate non-canonical Wnt pathways applicable to this proposal WNT5B MCC WNT4 ARHA PMC4546915__F1 Adaptive stress signaling in targeted therapy resistance in cancer CDC42 TBK1 BAD PTEN IRS1 TSC2 RALB TSC1 RALA PDPK1 MDM2 GRB2 TBC1D4 PMC2922838__F2 Gene expression profiling in whole blood of patients with coronary artery disease CAD CASP3 ZNF183 NDUFB3 PMC7137347__F1 LncRNA in regulating stem cell pluripotency SMAD2 SOX2 SMAD4 NODAL SIRT6 PMC5460107__F2 FLT3 signaling pathway FLT3 GRB2 MTOR PMC5247290__F3 TGF-b/BMP signaling pathway in osteoblast differentiation SMAD1 DKFZp781O1323 SMAD2 SMAD4 RUNX2 PMC4415606__F4 Arginine deiminase (ADI) hydrolyzes arginine into citrulline BAX ASL MTOR PMC5247290__F2 Canonical Wnt/b-catenin signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC12205714__F8 The potential protective mechanism of BJOE in irinotecan-induced delayed diarrhea mice TBK1 CGAS IRF3 PMC11354818__F12 Integrative Analyses Reveal the Physiological and Molecular Role of Prohexadione Calcium in Regulating Salt Tolerance in Rice TF ABI2 BIN2 EBF2 PMC11354818__F14 Integrative Analyses Reveal the Physiological and Molecular Role of Prohexadione Calcium in Regulating Salt Tolerance in Rice CYP1A2 CYP2E1 CYP3A4 PMC8582658__F1 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions APC LRP5 LRP6 CTNNB1 PMC3736482__F3 Associated intracellular cascades to physiopathology of vascular remodeling IGF1 EGFR VCAM1 SRC PMC8872751__F6 Transcriptome analysis reveals transforming growth factorB1 prevents extracellular matrix degradation and cell adhesion during the follicular-luteal transition in cows EGF ESAM COL1A1 TGFB1 SDC1 CLDN1 PMC8817718__F3 Damage-Associated Molecular Patterns As Double-Edged Swords in Sepsis NLRP3 TLR4 TLR9 PMC8817718__F2 Damage-Associated Molecular Patterns As Double-Edged Swords in Sepsis STAT3 SYK NLRP3 MYD88 PMC8724844__F7A Cellular RhoA Functions by the Integrated Application of Gene Set Enrichment Analysis SNAP23 BET1 VAMP2 STX6 SNAP29 VAMP3 STX8 STX17 VAMP8 VAMP4 VAMP7 USE1 STX5A VAMP5 STX16 STX11 STX18 STX7 VAMP1 YKT6 STX2 STX4A STX3A PMC6887687__F1 Main signalling pathways of programmed necrosis in cardiomyocytes TRADD MLKL KL CYLD TRAF2 FADD PMC2844426__F4 Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS) PTPN5 RAF1 NF1 GRB2 PMC8582658__F6 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions APC LRP5 LRP6 CTNNB1 PMC8582658__F5 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions APC LRP5 LRP6 CTNNB1 PMC8582658__F3 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions STAT3 HEL-S-133P LRP5 LRP6 PDK2 CCND1 CTNNB1 PMC8582658__F2 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions HEL-S-133P APC GSK3B LRP5 LRP6 PIN1 CTNNB1 PMC5341220__F2 Canonical signalling pathways activated by the EP receptors EGR1 ARHA CTNNB1 PMC5516996__F3 Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder RFWD2 TSC2 ATR FAS SIAH1 PERP CDK2 ATM MDM2 MYC PMC5516996__F5 Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder DBF4 CDC20 PCNA ORC6 SMC3 SMAD4 ORC1L MYT1 ORC3 SKP2 ORC2 CDK7 E2F4 CDC45 CDK2 PMC4266525__F1 Pathway for corticosteroid synthesis in the human adrenal gland HSD3B2 STAR CYP11B2 CYP11A1 HSD11B2 HSD11B1 PMC11522771__F2 Signaling pathways involved in cardiac fibrosis SMOC1 SMURF1 SMAD2 BMP2 SMAD6 PMC2852570__F1 Semaphorin signaling EVL GSK3B RHO PMC8615192__F5 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells SYK TSC2 GAL BAD FAR1 BCR RXRA RBL2 CD19 PTEN PMC8615192__F4 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells CRK JUN BAD VASP HEL-S-28 GRB2 SHE PMC8615192__F7 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells CAD LAT PROC OTP PMC8615192__F6 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells KLF2 CYC1 PTEN INS SKP2 ATG12 INSR C2 CDK2 ATM BOK NLK MDM2 PMC4644734__F1 Steps in the macroautophagy pathway ATG16L1 ULK1 ATG14 MTOR PMC3617041__F6 TGFB restoration by SMAD6 knockdown SMAD2 SMAD6 PMC7056928__F4 Cholesterol auxotrophic lymphomas accumulate squalene, an antioxidant-like metabolite ALK GLS GPX4 SQLE LDLR SLC7A11 FDFT1 PMC8444957__F1 Advances in research on pharmacotherapy of sarcopenia GDF8 IGF1 ACVR1 FST SMAD2 SMAD4 MTOR SRC ACE2 PMC1601946__F1 E3 ubiquitin ligases regulating the TGFB signaling pathway WWP1 SMURF1 ITCH APC SMAD4 SMURF2 PMC8615192__F1 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells THBS1 THSD4 SMAD2 SMAD6 SMAD4 NODAL ARHA HFE2 BAMBI RBX1 E2F4 FST SKP1 PMC8615192__F3 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells STAG2 DBF4 PCNA STAG1 SMAD2 SMC3 GSK3B CD7 SMAD4 ORC3 SKP2 ORC2 RAD21 CDK7 E2F4 CDC45 PI3 MCM3 DKFZp666G145 CDK2 MDM2 MCM2 CD6 PMC8685420__F8 Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer SERPINB5 PLG ARHA RHO PMC8615192__F2 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells CD44 VWF CD36 DMP1 CHAD CD47 PMC9335949__F7 Explore the Potential Ingredients for Detoxification of Honey-Fired Licorice (ZGC) Based on the Metabolic Profile by UPLC-Q-TOF-MS HEL-S-22 GSTM2 GSTM1 GSTT2 CYP2C9 CYP1B1 HEL-75 PMC11662066__SF3 Clinical pathway, Cohort II CRP MCU PMC3292309__F3 Activation of inflammatory mediators in pancreatic Beta-cells in type 1 diabetes STAT1 TRADD IL18 TRAF2 MYD88 PMC8940899__F7 MiR-323a-3p inhibits gefitinib resistance acquisition by targeting ErbB3/PI3K/Akt-EGFR/Erk1/2 signaling in colorectal cancer ERBB3 EGFR GSK3B PMC2850427__F2 Simplified Overview of the Purine Metabolism PathwayThe scheme is derived from KEGG Pathways hsa00230 (purine metabolism) and hsa00240 (pyrimidine metabolism) PNP UMPS ADA PMC5673628__F12 Schematic summary of baicalin-driven regulation of autophagy and inflammation during Mtb infection NLRP3 IL16 MTOR PMC10388552__F6 Aberrations in ion channels interacting with lipid metabolism and epithelial–mesenchymal transition in esophageal squamous cell carcinoma OSM INSR EGFR LIF PDGFA PMC7960610__F2 Schematic presentation of common molecular genetic aberrancies in parathyroid adenoma (PA; left) and carcinoma (PC; right) JUND APC RET CTNNB1 PMC2879972__F4 Illustration of different mechanisms of MUC1 and MUC4 for the repression of apoptosis MUC1 ERBB2 FGFR3 MUC4 FADD PMC8216764__F1 Potential Role for Integrin-Linked Kinase in Colorectal Cancer Growth and Progression via Regulating Senescence and Immunity RICTOR ILKAP TLR4 GSK3B HEL-S-28 PTEN SRC NCK2 TNF LIM2 PMC3412266__F1 Atypical PKC signaling pathways leading to lymphocyte activation and/or differentiation BCR RELA NFATC1 TRAF6 PMC1891745__F1 Diagram illustrating Functional JAK STAT PathwayThis “JAK STAT” pathway appears to be ubiquitous amongst vertebrates EPO GRB2 PMC5120225__F2 Signaling pathway of liver fibrogenisisThe injured liver produces various cell factors, which can activate transforming growth factor beta (TGFB) and platelet-derived growth factor beta (PDGFB), and bone morphogenetic protein (BMP) SMAD2 PMC3584306__F3 Obesity Pharmacotherapy: Current Perspectives and Future Directions SIM1 TRH CRH MC4R ARC PMC5812347__F2 Biochemical, Cell Biological, Pathological, and Therapeutic Aspects of Krabbe Disease IGF1 PMC2742785__F8 Cluster 2 genes significantly overlapped with those in the eicosanoid signaling pathway (P = 4.6E-05) HEL-S-22 PLA2R1 TBXA2R PLA2G3 PLA2G5 PTGS2 PLA2G2F PLA2G2E PLA2G2C LTB4R LTB ALOX12B PLCB1 GSTZ1 PMC2607021__F4 Genome-Wide Association Study Identifies Novel and Functionally Related Susceptibility Loci for Kawasaki Disease ZFHX3 CAMK1 LNX2 CAMK2D NUMB CAMK4 FGF10 LNX1 PMC5558921__F2 BER pathway is essential in the nervous system TDP1 PNKP LIG1 FEN1 PCNA POLE PMC11900433__F11 Unfolded protein response (UPR) pathway ATF4 XBP1 TRAF2 PMC8678597__F1 Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production TBK1 CGAS IRF3 PMC7435717__F5 Effect of Icariin, Purmorphamine, U0126, and PD98059 on osteogenic signaling pathways BGLAP SMO RUNX2 CTNNB1 PMC10376516__F4 Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics BAX MTOR PMC6991638__F7 Inhibitory effect of WKYMVm on osteoclast formation and bone resorption activity STAT3 CD9 FPR2 PMC8120466__F6 MUC3A induces PD-L1 and reduces tyrosine kinase inhibitors effects in EGFR-mutant non-small cell lung cancer MUC3A EGF EGFR PMC8902048__F1 Rotenone Modulates Caenorhabditis elegans Immunometabolism and Pathogen Susceptibility ATF5 ATF7 MTOR PMC4051228__F1 The folate/Hcy metabolic pathway RFC1 DHFR MTRR TYMS MTR PMC5734931__F2 Formation of autophagasomes in autophagy ATG10 ATG3 ATG12 ULK1 ATG5 PMC4622843__F4 Interaction network of differentially methylated diabetic genes EGF FBN1 TGFB1 COL1A2 COL4A2 SERPINB2 MYC TNF LAMA3 PMC5065302__F6 Mechanisms through which rolipram (ROL) attenuates pain behavior in bone cancer pain CCR2 PDE4B CCL2 IL1B PMC5920380__F1 Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway SPOP KIF7 SUFU GSK3B SMO GLI3 PMC4348071__F1 Exploiting the head and neck cancer oncogenome: Widespread PI3K-mTOR pathway alterations and novel molecular targets PIK3CA EGFR RPS6KB2 NUMB PTEN MTOR NOTCH2 RHEB CDKN2A TSC2 RICTOR TSC1 TP63 FAT1 CCND1 NOTCH1 PMC3669657__F6 Observed effects of Hedgehog and Wnt inhibition, and Sox17 overexpression in HOG cells SOX17 SUFU DHH LRP5 SHH IHH LRP6 SMO TCF4 CCND1 SFRP1 CTNNB1 PMC3310485__F4 Schematic of the role of BDNF in the brain reward pathway associated with addiction TH BDNF PMC3408604__F1 Cardiac myocyte signaling coupled to phosphodiesterase (PDE) 5 TRPC6 GATA4 PMC9136126__F6 Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model BAX NR1H3 CCL25 CCL11 SLC27A2 FABP6 PMC4526101__F3 The type I diabetes mellitus pathway in which HLA-A, HLA-B, HLA-C, HLA-DPB1 and GAD1 are involved IFNG CD80 FAS PRF1 IL2 INS PMC3390457__F1 Neuroprotective signaling pathways employed by Erythropoietin EPOR EPO PMC3514635__F4 Intracellular trafficking proteins involved in CMT neuropathy FIG4 SH3TC2 MPZ MTMR2 PMP22 MFN2 GDAP1 FGD4 EGR2 PMC4526101__F2 The systemic lupus erythematosus pathway in which HLA-DPB1, HIST1H4J, HIST1H2BO, H3F3C, H2AFY, H3F3A, HIST2H3D, HIST1H4D, HIST2H4B, HIST1H2BL and HIST1H4K are involved TH SARNP IL10 BCR C2 APC MAL CS PMC11058998__F4 Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors LATS1 LATS2 RAB5C SMAD2 MCU MTOR PMC11058998__F3 Piezo1 affects the occurrence and development of diseases through multiple signaling pathways PIEZO1 NLRP3 MTOR PMC2287275__F2 Mesenchymal stem cell dysfunction in HGPS HEY2 HES3 MSC BOK HES1 HES5 PMC6651655__F3 Representation of S100B effects on Caco-2 cells ELL MTOR S100B PMC11854313__F2 Biosynthetic pathway of terpenoids IPP MVK STS PMC7256186__F1 Warburg effect in melanoma cells caused by BRAFV600E mutation leading to constitutive activation of MAPK pathway HEL-S-68p HK2 ENO1 MYC PMC7513299__F1 Adipocytes in EOC metastasis CD44 HGF IGF1 PMC11612565__F4 Mechanisms of EC pyroptosis in sepsis HMGB1 CGAS GSDMD NLRP3 TLR4 IL33 DEFA1B DEFA3 PMC11612565__F3 Specific pathophysiological mechanisms of EC apoptosis in sepsis STAT3 BAX SLIT2 PIM1 SERP1 ROCK1 SSH1 NRP2 MTOR TUG1 PMC11612565__F6 Relationship of EC autophagy and function and EC autophagy-related mechanisms in sepsis CD74 NLRP3 PTBP1 NAMPT APOL1 MIF MTOR SKP2 RUNX2 SIRT1 PMC11612565__F5 Mechanisms related to ferroptosis of ECs in sepsis ATF3 GDF11 KEAP1 GPX4 STEAP1 SDC1 IGF2BP2 NOX4 SIRT1 PMC10865661__F15 Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IKKB/NFKB p65 signaling pathway: insights from in silico and in vivo investigations CDC42 BAD COX2 DAO PMC8088756__F2 Demyelination as a result of an immune response in patients with COVID-19 CD14 IRF3 MYD88 PMC4445098__F6 Network between MAPK signaling pathway-related genes and miRNAs CACNB1 CACNA1A TAOK2 TGFB1 ARRB2 FLNB MAP3K12 TNFRSF1A MAP3K14 MAP3K7IP1 HEL-S-102 FGFR3 RRAS CACNB3 PMC5387690__F7 A Caenorhabditis elegans Genome-Scale Metabolic Network Model MAX FH MALL PMC9227929__F2 Interactions between Tryptophan Metabolism, the Gut Microbiome and the Immune System as Potential Drivers of Non-Alcoholic Fatty Liver Disease (NAFLD) and Metabolic Diseases ID2 IDO1 IDO2 PMC8447597__EV3 Drugs targeting SARS‐CoV‐2 and host protein interaction ATP5F1D HEL-S-271 DDR1 BMPR1A GSK3B RPS8 ATP5PO SERPINB5 RPL26L1 FLT4 RPS17 RPL10 A2M CDH2 DCD SORD PRIM2 PRIM1 MVK RPL19 RPL23A POLA1 COL18A1 POLA2 SIGMAR1 APOB DIABLO TPD52L2 PPIH VAMP2 EGFR AKT3 DHFR RPS6KA6 IGF2R PCMT1 RPS13 SLC5A2 RPS6 HEL-S-72p GUCY1B1 ERBB4 RPS2 HEL-S-7 PHB2 SKP1 ERBB2 RDH12 RPS9 PYCR2 PMC9694790__F2 Advances in Fucoxanthin Research for the Prevention and Treatment of Inflammation-Related Diseases TRAF6 IL1B MYD88 PMC9694790__F4 Advances in Fucoxanthin Research for the Prevention and Treatment of Inflammation-Related Diseases BAX CDK6 CDK2 BCL2 GADD45A CDK4 PMC8197962__F1 ZNF-281 as the Potential Diagnostic Marker of Oral Squamous Cell Carcinoma MMP9 GPR49 SOX4 CTNNB1 PMC7345850__F9 Left panel: Balanced autophagic flux LRRK2 SQSTM1 M6PR PMC11612565__F2 Effect of DAMPs on vascular ECs during sepsis or severe bacterial infections HMGB1 NLRP3 PMC8958883__F1 Wnt/Beta-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma APC GSK3B AXIN1 LRP5 LRP6 CTNNB1 PMC6907065__F2 The mechanism of UVA-modulated HO-1 regulation through the PERK and Nrf2 signal pathway KEAP1 ATF4 EIF2A PMC8944161__F1 Clinical benefits of PD-1/PD-L1 inhibitors in patients with metastatic colorectal cancer: a systematic review and meta-analysis ZAP70 CD80 LAT APC IL2 LCK PMC11671274__F1 Intestinal changes in T2DM IFNG PYY IL1B MYD88 PMC4773818__F6 Pharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention TGFBR2 SMAD2 ARHA TGFBR1 PMC5790278__F7 Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma STAT3 SOCS3 MTOR PMC7708728__F1 Systematic Review of the Kynurenine Pathway and Psychoneurological Symptoms Among Adult Cancer Survivors CRP KMO TNF PMC6086625__F5 Kinases associated with the CX3CL1/CX3CR1 axis EGFR PTK2B SRC ITGB3 PMC11513491__F3 Schematic illustration proposed for the probable role of PI3K axis in AML cells PTEN MTOR PMC4151374__F2 Interaction network using Pathway studio VPS54 KLKB1 SPRN APOE PRND PLG PRNP TNF LAMA3 PMC4151374__F1 Biological network inferences for a protection mechanism against familial Creutzfeldt-Jakob disease with E200K pathogenic mutation NRXN2 KLKB1 FRS3 APOE PLG PRNP GRB2 LAMA3 PMC4334309__F2 Directed evolution of the nonribosomal peptide synthetase AdmK.Notes: Andrimid is biosynthesized by a hybrid nonribosomal peptide synthetase/polyketide synthase pathway TG ADM PMC7836194__F2 Curcumin mediates miRNA regulation in PC DNMT3B FOXD3 ATG2B PTEN CCND1 CDK4 CTNNB1 PMC3875780__F3 Human intestinal innate myeloid cells TLR4 CD14 TLR5 IRF4 PMC6315509__F1 Notch and Wnt signaling pathways GSK3B LRP5 LRP6 PMC7356262__F8 Canonical pathway “Osteoarthritis Signaling” for Epi C vs HMGB1 TIMP3 SP1 MMP10 SP7 SMAD4 NAMPT MMP9 RBPJ HDAC3 MTF1 DLX5 HES1 PMC7356262__F7 Canonical pathway “NF-kB Signaling” for VA vs CD40 EGF LTA TGFA TRADD TIRAP RELB TAB3 PELI1 MYD88 UBE2V1 HEL-S-71 NGF MAP3K7IP1 PLCG2 RELA REL LCK FADD PMC4661887__F4 Mechanism of action of soy peptides in HepG2 cells RICTOR LDLR MTOR PMC7356262__F6 Canonical pathway “Osteoarthritis Signaling” for VA vs HDAC3 HMGB1 SP1 SOX9 MMP10 BMP2 SP7 SMAD4 NAMPT COL2A1 CTNNB1 PMC3461959__F3 Blastocyst Lineage Segregation and Stem Cells SOX17 SOX2 GATA6 GATA4 PMC4465084__F1 Investigational approaches targeting the factors contributing to celiac disease pathogenesis HLA-E APC MICA MICB TNF PMC9097215__F2 Tumor Suppressor Kinase LKB1: Metabolic Nexus HK2 PDC ENO1 HIF1A PMC8064323__F10 Gene clusters annotated to drug addiction pathways in HIV+ prefrontal cortex and the effect of Meth use PTPN5 CANX PIK3R1 GRIK2 MAOA GABRG2 GABRB1 ADCY8 CACNA1F TPH1 CAMK2A DRD1 GRIK5 PDE1C CHRNB2 PDE1B GRIN3B D4S234E TPH2 PAH GRIN1 PDE4A CALML3 CACNA1A CACNA1C CHMP5 FOSB CACNA1B DLG4 GRIK1 GRM2 RELN GABRA3 GRIK3 SYNGAP1 DAB1 PDE1A GABRA2 ADCY3 HOXA4 ADRB2 ADCY1 TH GRIA3 GRIN2B GRIA2 GABBR2 HTR2A GABRA4 GRID2 GABRG3 GRIN3A GABBR1 GABRE CREB3L4 ADCY9 SLC18A2 ADCY6 GRIA4 PPP2R5D CACNA1S GUCY2D LRP8 PDE7B CALY KCNJ6 GABRB3 OPRM1 GABRG1 CAMK2D SSR4 PMC7867092__F2 Leptin-promoted lipid metabolic reprogramming in cancer cells STAT3 CD36 PMC3707630__F7 CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex CD44 CD74 RHO MIF SRC CCND1 PMC9133699__F9 Reconstruction of a Genome-Scale Metabolic Network for Shewanella oneidensis MR-1 and Analysis of its Metabolic Potential for Bioelectrochemical Systems APC MAL HP PMC8380940__F1 Engineering Biological Electron Transfer and Redox Pathways for Nanoparticle Synthesis MAX PMC6506734__F1 Downstream signaling pathway of adiponectin NR1C1 SP1 APPL1 PMC6952810__F2 MicroRNAs regulating key genes of the TGFB signaling pathway TF TGFBR2 SMAD2 SMAD4 TGFBR1 PMC5085112__F7 Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease FAS ABCG5 HMGCR ABCB11 ABCB4 LDLR PMC5364554__F9 Acceleration of bone regeneration by activating Wnt/Beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis FRAT1 APC GSK3B LRP5 LRP6 RUNX2 CTNNB1 PMC6291520__F6 Graphical summary MTOR ATG5 PMC5962649__F4 Historic and updated model of IRS signaling RICTOR GRB10 CUL7 RS1 FES AHR SOCS3 GRB2 GAB2 IRS1 PMC12137631__F4 Molecular mapping of HFD-induced liver inflammation and metabolic dysregulation HFD induced liver steatosis through activating key inflammatory and lipid metabolism genes LPL PPARG PIK3CA ABCG1 INSR SCD NFKB1 PIK3R1 CXCL16 TNF IRS1 PMC5463358__F3 Microglial M1 and M2 signaling in neurodegeneration, and potential targets for neuroprotection SYK HMGB1 IFNGR1 JAK3 GSK3B CD14 ARG1 CCL2 MYD88 IFNG STAT1 IFNGR2 COX2 TLR4 JAK1 TYK2 PMC3296080__F1 Interactions between insulin-like growth factor-1 receptor (IGF-1R), insulin receptor (IR), and epidermal growth factor receptor (EGFR) signaling pathways IGF2R BAD EGFR PTEN IGF1R GRB2 PDK2 MTOR PMC12137631__F3 High fat diet disrupts Insulin signalling Pathway PIK3CA INSR PTPN1 PIK3R1 IRS1 PMC2241839__F3 Cholesterol biosynthesis pathway GGPS1 ID2 HEL-S-62p EBP SQLE SC5D DHCR24 MVK HMGCR ACAT2 C2 PMVK MVD DHCR7 FDPS HSD17B7 TM7SF2 PMC8407594__F1 Combined overview of all qualitative Wnt (sub-)models found within the 19 Wnt simulation studies SOX17 NKD1 EGF DKK1 EGFR APC GSK3B LRP6 LFNG HES7 AXIN2 PMC6297716__F4 Scheme illustrating the signaling pathways and transcription factors contributing to SND1 promoter activation SP1 XBP1 SND1 PMC5354998__F10 Integrated genomic and molecular characterization of cervical cancer STXBP4 HIF1A MYC MAPK8 IFNG MAIP1 SHH TFAP2C GCK RAB38 NR1i1 TIMP3 MSH2 AXL ID2 HK2 PERP CRKL MAPKAPK2 TRPV1 ALAS1 KLK3 EVPL TUBB FURIN AEN GPX2 EIF4G1 ALDOB COL18A1 RXRA APOB BCL2 GREB1 COMP CABL1 BAD ITGB4 PGR NDUFV3 SFN XBP1 UCP2 RARA FOSL2 YWHAQ ABCA3 FOXA1 ARRB2 KRT14 SFTPD TCF7L1 FECH AXIN2 CSDE1 WWP1 FTH1 NRG1 SMARCD3 ERBB2 STAT4 FOXA2 GJA1 ADA PMC3248194__F3 RIP Kinase-Mediated Necrosis as an Alternative Mechanism of Photoreceptor Death PYGL FAS PIG59 TAB3 CYLD TRAF2 FADD PMC6866135__F1 IRAK1 kinase drives distinct prosurvival responses to microbial infection and ionizing radiation IRAK1 TRAF6 PIN1 IRAK4 MYD88 PMC6031874__F1 Simplified scheme of transsulfuration pathway VIT pcap PMC3294197__F3 Ingenuity Pathway Analysis of genes that are differentially methylated (P<1.8 × 10−6) between normal mucosa of cancer patients and controls HGS EGF PTPN22 NR2A1 CCNG2 MEPCE SERTAD3 IL2 USHBP1 MB PMC7085392__F3 Activation of Akt after joining to PIP3 by its PH domain RHEB TSC2 TSC1 GSK3B MDM2 PMC11039944__F2 Alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma CD44 EPCAM AFP CXCR4 PMC6207598__F2 Toll-like receptors (TLRs) and their role in the evasion of the immune response induced by hMPV TLR3 TLR4 TLR9 TLR7 TRAF6 MYD88 PMC7504460__F1 Mechanisms of obesity-induced development of endometrial cancer (EC) NR2A1 IGF1 SHBG ADIPOR1 IGF1R PMC8074203__F3 Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights IL19 KHK FAS NLRP3 TLR4 IL18 PMC7504460__F2 Insulin-PI3K signaling facilitates cell proliferation and glucose metabolism via serine/threonine protein kinase B (AKT)-dependent and -independent mechanisms RPS6 TXNIP MTOR HEL-S-87p PMC6862746__F9 HCC microenvironment inhibits SIRT4 expression in TAMs and modulates alternative activation of TAMs, which contributes to HCC development STAT3 SIRT4 ARG1 PMC7314952__F3 Ferroptosis, NRF2/antioxidant response element (ARE)–GPX4 pathway KEAP1 GPX4 SLC7A11 PMC11037416__F2 Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages RIPK3 GSDMD RIPK2 TRADD MLKL TLR4 RIPK1 TRAF2 FADD PMC11037416__F1 Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages TF GLS GPX4 ULK1 ASCL4 LPCAT3 MTOR ATG101 ATG10 ATG3 ATG12 ATG5 HEL-S-64p ULK2 ADA PMC11028018__F5 Proposed model illustrating the inhibitory effects of GBE on TGFB downstream signaling pathways COL1A1 SMAD2 PMC7252250__F4 Pathway 1: Insufficient activation of immune response in the middle ear epithelium cells in otitis media TBK1 PYCARD MAVS IKBKE IFIH1 BPIFA1 IRAK1 LYZ TRAF3 IRAK4 MYD88 NLRP3 CASP5 TICAM1 NOD2 IL18 NOD1 TLR7 IFNA1 IL1B JUN CASP8 DEFB4B TICAM2 IRF3 IRF7 IL1A IL6 TNF CARD6 FOS NLRP1 TLR3 NFKB1 IKBKB NFKBIA MAP3K7 BCL2 IFNB1 CARD9 PMC8377014__F1 Screening of Potential Biomarkers for Gastric Cancer with Diagnostic Value Using Label-free Global Proteome Analysis GC SET PMC4437509__F5 Downstream components of ERK in SCN neurons PER1 MTOR PMC11037416__F5 Pyroptosis mediates macrophage reprogramming of the tumour immune microenvironment STAT3 HMGB1 GSDMD NLRP3 TLR4 GSDMC GZMA GSDMB DFNA5 PMC4437509__F7 JNK MAPK in the circadian clock PER3 PER2 PER1 CRY2 CRY1 PMC4437509__F6 P38 MAPK in the circadian clock PER3 PER2 PER1 CRY2 CRY1 PMC11037416__F3 Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages NLRP3 TLR4 CCR2 SIRPA MTOR CXCL10 CCL2 CD47 PMC11993993__F2 LPS proinflammatory signaling pathway TIRAP MAL CD14 IRAK1 IRF3 IL6 TRAF3 TNF TRAF6 CCL2 IRAK4 MYD88 LBP IL1B PMC5346319__F4 p53 dependent and independent tumor suppressive functions of ARF FOXM1 ATR CTBP2 WRN CTBP1 ATM MDM2 BCL6 PMC10957552__F1 Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis BMP15 GREM1 HAS2 PTGS2 GDF9 PMC11771717__F1 KRAS signaling pathway functions differently in normal cells compared to cancer cells EGFR GRB2 KRAS PMC8773878__F5 Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment CD40 CD80 EGFR PMC9636624__F4 Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation UBC CYP7A1 PLTP PMC7570648__F2 Each herb in fighting cancer through oxidative stress pathways PTEN HIF1A PMC3957730__F27 Glycolysis and gluconeogenesis in the mesophilic halophile Haloferax volcanii KHK PTS GIPR PMC8712267__F5 Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19 GNG5 HEL111 GNG12 ALB GNAS EZR RALA F9 CDH2 ORM1 SERPINA1 HRG TGFBR3 HEL70 VEGFA HEL114 C4BPA GNA11 SAA4 VCAM1 ACTG2 SDC2 GNA13 CREB3L3 CDC42 EGF ARHG F5 WASL HEL-S-269 C4BPB RHO ORM2 GNB1 MYLK HEL74 MYH9 SAA2 NPRC CRP RAMP3 MYL6 PFN1 SDCBP RBP4 APOA2 HEL-S-92n S1PR3 ARHGDIB FTL HP LBP RRAS2 PS1TP5BP1 PMC6717289__F6 Our proposed model of KRAS and TP53 oncogenes driving PDAC malignancy via the ARF6–AMAP1 pathway RAB11B EPB41L5 TEAD3 MVP ARF6 ETV4 MTOR KRAS EIF4E PMC5948914__F2 Gemcitabine pharmacologic pathway SLC29A3 RRM1 RRM2 HELB TYMS DCTD ABCC10 CDA POLA2 CTDP1 SLC29A1 SLC28A3 RRM2B ABCC5 ABCG2 POLR2A POLE NDP PMC5579704__F3 Proposed mechanisms by which dietary polyphenols inhibit EMT and cancer metastasis EGF HGF PTCH1 SMO CTNNB1 PMC9273153__F3 Regulation and Signaling of TGFB Autoinduction JUN SMAD2 SMAD4 ARHA MTOR FOS EIF4E PMC4103658__F7 GATA6 Levels Modulate Primitive Endoderm Cell Fate Choice and Timing in the Mouse Blastocyst FGF7A GATA6 PMC4323494__F9 Schematic model for the involvement of TAK1-NLK in IL-1Beta-triggered ATF5 stabilization and C/EBP activation MAP3K7IP1 ATF5 EBP NLK IL1B PMC7438931__F1 mTORC1 pathway and regulation RHEB MLST8 TSC2 TSC1 ULK1 TFEB MTOR DEPTOR PMC9185982__F6 SRF: a seriously responsible factor in cardiac development and disease KLF4 TRIM32 TRIM24 GSK3B MYOCD ARHA RND1 CTNNB1 PMC2640456__F1A Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP-regulated genes MAPK1 HEL-S-72p HMGB1 METAP2 HEL-S-269 EIF4E NEFH RPL19 SCG2 PPFIBP1 RPL10A PAIP2 AAG1 EIF4A1 DDX3X PMC6491842__F4 Enriched genes from the ANOVA statistically significant disease status gene list (p-value < 0.05) found in the KEGG Alzheimer's disease pathway (hsa05010) [Kanehisa and Goto, ; Kanehisa et al., , ] LPL IDE CASP9 BAD CR1L GSK3B SNCA CPO RYK TNF GNE CASP3 APP APAF1 FADD PMC4011321__F8 Putative pathway of the inhibition of LPS-activated inflammatory signaling by compound 7 SYK TLR3 TLR4 IRAK1 ATF2 TRAF6 MYD88 PMC7911745__F1 NFKB signaling pathway and the genes associated with BD-like phenotypes TRADD NFKB1 TNFRSF1A RELB RIPK1 TRAF6 TNF TRAF2 MYD88 PMC4467640__F1 Cellular regulation mediated by extracellular matrix (ECM).Notes: The action of ECM components on the major signaling pathways of tyrosine kinase receptors, their links, and the outcome on tumor cell and chemotherapeutic response RHEB BAD TSC1 MAPKAPK2 HEL-S-28 PTEN HIF1A MDM2 MTOR MYC CCND1 EIF4E PMC7145977__F4 Hypothetical model showing the possible role of Sirtuins and circadian system in the pathogenesis of diabetic lung SIRT3 FOXO3A SIRT1 SIRT6 PMC8165182__F1 An Overview of Lung Cancer in Women and the Impact of Estrogen in Lung Carcinogenesis and Lung Cancer Treatment CXCL12 EGFR IGF1R SRC CXCR4 PMC9175535__F4 Reposition of the fungicide ciclopirox for cancer treatment RHEB MLST8 TSC2 TSC1 BNIP3 MTOR EIF4E PMC2684656__F1 Diagrammatic representation of the signalling pathways activated in the unfolded protein response following ER stress TF EIF2A TRAF2 PMC8582018__F2 Molecular Mechanisms of Ferroptosis and Its Roles in Hematologic Malignancies LOX GPX4 ALOX12 SLC7A11 PMC8582018__F1 Molecular Mechanisms of Ferroptosis and Its Roles in Hematologic Malignancies POR IREB2 SLC3A2 IPP STEAP3 KEAP1 GPX4 LPCAT3 HEL-S-102 FACL4 SLC7A11 ATG5 PMC3632609__F1 Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain HEL-S-90n KYNU KMO AFMID IDO2 PMC10648005__F1 Main molecular consequences of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway activation FOXO1 PTEN MTOR PMC7936154__F1 Examples of potential miRNA-mediated regulation of metabolic pathways in chickens BAD NR1C1 IGF1 RXRA PMC3822721__F3 FHL1 isoform KyoT2 and Notch signaling PIAS1 NOTCH2 NOTCH3 NOTCH1 PMC5919742__F7 Cell-type expression patterns of carbon metabolism-related genes in V OGA ACP2 PCK2 UXS1 MBP MGRA FBP1 GIP PGM5 PCK1 HEL-S-26 PMC4598307__F7 Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism SENP1 ADSL ADA PMC9530844__F7 Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin EGFR GRB2 PMC6890664__F4 Altered cancer pathways in ASL, CCA and HCC EGF HEL113 SSH2 RHO FGF10 FLNA TGFBR1 FGF8 CTNNB1 TRRAP GNAS PRKCI TRIM28 ALK FOXO1 TTN ATM HEL2 BRCC3 PMC7791126__F3 The TGFBeta-induced canonical SMAD and noncanonical signaling pathways FAS SMAD2 SMAD4 MICA MMP9 MTOR RHO TRAF6 ID1 GATA3 IFNG TRAF4 MMP2 BCL2 BMF IL11 FOXP3 GRB2 PMC6304934__F7 FSIP1 regulates autophagy in breast cancer TSC2 TSC1 FSIP1 ULK1 APC MTOR CTNNB1 PMC4315163__F4 G protein-coupled receptor pathway is involved in transmembrane signaling and diverse physiological functions including hormone signaling, regulation of cell contraction, cell migration, growth and differentiation ADRBK1 FYN GRB2 PMC7660609__F2 Role of HO-1 in I/R injury and cardioprotection HEL-S-62p PMC8853744__F2 Senescence in chronic wounds and potential targeted therapies DDB1 IL6 PMC5721403__F1 Targeting to bile acid and lipid metabolism in NASH treatment FGF8A BAX BAD COL1A1 MMP2 CYP27A1 PMC7460084__F1 Schematic presentation of transforming growth factor-beta (TGFB) signaling pathways SMAD2 SMAD4 MTOR PMC8020338__F4 Ingenuity pathway analysis of the TREM1 signaling pathway in the DH82 cell line treated with B TREM1 IRAK1 PMC8020338__F3 Ingenuity pathway analysis of the Toll-like receptor (TLR) signaling pathway in the DH82 cell line treated with B JUN MAP3K7IP1 TRAF6 PMC11351392__F3 Targeting the Nrf2/HO-1 axis for the treatment of IBD NLRP3 GPX4 PMC1431703__F5 Comparison of results with the known response pathway CDC42 CDC73 FAR1 ISY1 PLP2 MRPL16 MRPL28 MRPL9 MRPL10 PMC5824365__F6 String pathway to show the node of PD effects NR2C2 MDK KLF4 MYB MAFG HIF1A MAPK3 CTNNB1 NR3A2 TPO HDAC2 CCND1 MAPK1 IL10 JUN LMO2 SP1 KLK3 BCL2L11 FOS CD34 HDAC1 tal-1 RELA CREBBP STAT4 EP300 MBD3 CXCR4 PMC5357489__F3 Cross talk of the Wnt/Beta-catenin pathway with the epidermal growth factor receptor (EGFR) and fibroblast growth factor (FGF) pathways in hepatitis C virus (HCV)-related hepatocellular carcinoma EGFR NKD2 GSK3B LRP5 LRP6 CCND1 PMC8530779__F7 Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing MAVS TLR3 IRF3 IRF7 TLR7 TRAF3 TNF IL1B MYD88 PMC9222488__F1 Clinical and Mutation Spectrum of Autosomal Recessive Non-Syndromic Oculocutaneous Albinism (nsOCA) in Pakistan: A Review SLC45A2 OCA2 DCT SLC24A5 PMC3840450__F1 The main actors intervening in the canonical and noncanonical NFKB activation pathways CD40 RELA RELB PMC10892344__F6 Schematic diagram generated by IPA of the death receptor signaling pathway with which the DEPs with |FC| ≥ 1 ACIN1 BANF1 LMNA FADD PMC3612647__F1 A lithium-sensitive family of small-molecule phosphatases and the sulfate assimilation pathway PAPSS2 FBP1 HEL20 PMC3840450__F2 Mechanisms of NFKB activation in T-ALL leukemic cells BCL10 NFKB2 RELA CYLD HES1 PMC9693004__F3 Hematotoxic Effect of Respiratory Exposure to PHMG-p and Its Integrated Genetic Analysis ARHGAP4 CD36 MCL1 HAMP IL6 RHO BHLHB2 MRPS23 CLCC1 RB1 IFNG HEL-S-125m LACTB MMP2 TYK2 PMC8838174__F5 In Vitro Anti-Cancer Activities and Mechanisms of Action of 9-Methoxycanthin-6-one from Eurycoma longifolia in Selected Cancer Cell Lines HTRA2 BAX BIRC6 BAD FAS CAD MCL1 ANXA2 CYCS GAS2 TNF HEL-S-162eP ROCK1 APAF1 DIABLO PMC4013580__F6 A schematic model presenting the pathway of BMP4 to affect foam cell formation BMPR2 ABCG1 SMAD1 DKFZp781O1323 BMP4 ABCA1 PMC5454932__F2 Intracellular GH signaling MTOR SRC PMC1297590__F2 Ubiquitination of key signaling in anergic T cells JUN NEDD4 ITCH PC FOS PMC6389164__F3 The genes and their functional relationships within the RLR signaling pathway CD40 CD80 TBK1 IFNA8 TNFAIP3 MAVS IKBKE IF1AA9 IFIH1 CCL5 DHX58 CCL2 IKBKG STAT1 RIPK2 RIPK1 ISG15 IFNA1 CASP8 IRF3 IRF7 CXCL10 HEL-S-125m TRIM25 RELA NFKBIA MAP3K7 DDX3X IL12B TRAF2 PMC5125391__F2 Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells HDAC3 HDAC1 BAX GSK3B BBC3 HDAC2 PMC2603135__F6 Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data BAD TINF2 MSH2 PCNA RRM1 RRM2 BLM HDAC1 FANCD2 RAD1 BRCA1 ATM MDM2 MCM2 PMC2603135__F5 Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data GAS7 HDAC1 KLK4 GTF3C5 MTDH ZNF175 DDIT4 RRM2 UTS2 KHSRP PMC8276974__F2 Both calcium channel signaling and ITIM containing receptor signaling are involved in leukemia progression by binding to and activating the Ca2+/calmodulin dependent protein kinase family STAT3 BOC CTNNB1 PMC3153165__F1 Roles of the NFKB-mediated inflammatory pathway in cellular transformation and in cancer cell survival, proliferation, invasion, angiogenesis, and metastasis COX2 VCAM1 MMP9 CXCR4 TNF CCND1 PMC9069786__F11 Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway STAT3 NLRP3 SOX4 IL1B PMC8591178__F1 Inborn errors of IL-6 family cytokine responses CNTFR OSM LAT OSMR LIF CLC IL11RA PMC7004353__F9 Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development ACSS2 IGF1 HEL-S-53e LRAT RDH10 RDH11 CYP1B1 PMC7235771__F1 NGF and TrkA binding, just as BDNF and TrkB, leads to dimerization and autophosphorylation of receptors at tyrosine residues NGF RHO BDNF PMC7069804__F2 Schematic of microRNA networks affected by HIV virus CDC42 TNPO3 PMC5688216__F1 Regulatory T cell development (Churlaud et al TEC TH CD80 FOXP3 PMC5650366__F8 Global gene expression profile of cerebral ischemia-reperfusion injury in rat MCAO model ATG10 BAX ATG3 ATG12 ELF2 ATG14 ATF4 WFS1 TRAF2 PMC2213224__F8 Interaction of CagA with Crk plays an important role in Helicobacter pylori–induced loss of gastric epithelial cell adhesion HRAS CRK RAF1 CRKL GRB2 SRC RAC1 PMC4535695__F1 Classical pathway for T cell activation CD80 PMC3807853__F9 IL-33 markedly activates murine eosinophils by an NFKB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop TFEC IL33 ADORA2B CXCL2 CXCL10 CLEC4E CCL17 PMC8676434__F4 Evolution of regulated cell death pathways in animals and their evasion by pathogens BAX TRADD RIPK1 FADD PMC8761471__F14 Long non‐coding RNA MIR31HG as a prognostic predictor for malignant cancers: A meta‐ and bioinformatics analysis MAX SYK MYB BAD GAL CAD LAT PAG1 RBL2 CYC1 PTEN CD19 DAO BCR RXRA DAP APIP PMC10556577__F1 TGFB signaling pathways (Activin and Bone Morphogenetic Protein) SMAD2 SMOX PS1TP5BP1 PMC5348720__F1 Viral infections in type 1 diabetes mellitus — why the B cells? BACH2 CTSH IRF3 IRF7 IRF4 TNF GLIS3 IRF6 STAT1 USP18 JAK1 TYK2 IL1B PMC3834158__F3 Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats TG ABCG1 HMGCR SCARB1 FASN LDLR APOB ELOVL6 ABCA1 CPT1A PMC6885838__F10 Effects of hydrostatin-SN10 on the JAK2/STAT3 signaling pathway STAT3 BCL2 TYK2 PMC3834158__F4 Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats PPARG TG NR1C1 CROT FASN CS ELOVL6 PMC6981958__F1 Interaction of p53 with different E3 ligases RFWD2 TRIM71 MDM2 PMC10967197__F10 The role of the IGF2BP2-TRPM2-AS/PABPC1-NUMB-NOTCH1 axis in GBC angiogenesis AGO2 NUMB IGF2BP2 HES1 PABPC1 NOTCH1 PMC10239798__F7 Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A STAT1 STAT2 IRF3 DCP1A PMC7285825__F11 Ingenuity pathway analysis of functional relationships among genes involved in the IFN signaling pathway IFNG BAX STAT1 STAT2 IRF9 PIAS1 IRF1 JAK1 TYK2 PMC11820142__SF7_3. Graphical abstract IL1R1 ROCK2 ROCK1 IRAK1 ARHA TRAF6 ACE2 IRAK4 MYD88 PMC4382988__F4 Ingenuity pathway analysis (IPA) of differentially expressed proteins KRT1 TAPBP PYCARD PML BPIFA1 CTSS ISG20 ACTA2 DPT HSPA2 ISG15 RTKN MATN1 PSME2 DCN ORM1 HAPLN1 OAS3 KRT4 BPIFB1 SERPINE2 HEL-S-130P LAP3 PLVAP NCKIPSD DKFZp686P11128 XDH HP PMC7584092__F10 Drug-compound-target-pathway network ALOX5 F10 F7 CASP3 PTGS1 PTGS2 PMC5798330__F2 Transcripts relating to the classical complement pathway are overabundant in subclinical and active TB C6 CD59 C7 SERPING1 MASP2 HEL-S-62p CR2 C1QB FCGBP IL6 FCGR1A C4A CR1 MASP1 C2 C9 C4B_2 PMC5955724__F1 Working model for Eph receptor function in tumor promotion and tumor suppression EGFR ERBB2 ARHA PMC3752772__F2 NFKB activation pathways triggered by TNF family signaling RELA RELB TNF PMC5819904__F1 Core components of the Hippo pathway LPA TEAD2 TEAD3 RHO TEAD4 PMC5819904__F2 Regulation of the Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 CCND1 PMC8873791__F6 Shenkang Pills on Early-Stage Diabetic Nephropathy in db/db Mice via Inhibiting AURKB/RacGAP1/RhoA Signaling Pathway AURKA AVPR2 NEK2 ADAMTS5 TERT EPHB2 TGM1 AURKB P2RY2 ITGA2 ADAM12 KCNN2 SLC5A2 PMC5819904__F5 Regulation amongst the Wnt/Beta-catenin, LPA and TGFB/Smad signaling pathways and YAP/TAZ of the Hippo pathway LATS1 LPA EGF APC RHO PMC6986449__F2 Differentially methylated promoter regions of genes in PI3K-Akt and NFKB signaling pathways during acute malaria BAD PTEN MTOR CTNNB1 EIF4E RHEB TSC2 TSC1 TOX CDC37 MDM2 GRB2 CCND1 PMC11853522__F3 Interaction between nutrient-sensing pathways and mitochondrial oxidative stress and chronic inflammation SIRT3 LRRC17 CGAS SIRT7 PINK1 IGF1 IGF1R MTOR INS SIRT1 SIRT6 PMC2847476__F3 Immunoregulatory Functions of mTOR Inhibition KLF2 PIM2 CCR7 PTEN FOXP3 PMC7378638__F5 Enterohepatic action of FXR and FATP5 FGF8A TG FGFR4 PMC4829974__F3 Genomic profiling of Sézary Syndrome identifies alterations of key T-cell signaling and differentiation genes CDC42 ARID1A ZAP70 ATR PDCD1 SOS1 F5 LAT CARD11 RPS6KA1 PTPRC ATF2 MAPK8 MYC RB1 CDKN2A PLCG1 BCL10 CCNE1 F3 CHEK2 ATM ITK CCNB1 CCND1 CDK4 CDC2 CCND3 MAP3K19 HIC1 LCP2 PTPN11 CTLA4 ARID3A PTPN6 ICOS CDKN1A PRKCQ HOXA9 IKBKB CHEK1 CREBBP CDK2 EP300 GRB2 CDC25B LCK PMC10374588__F2 Pathways controlling pyroptosis, apoptosis, ferroptosis, and cuproptosis BAX SLC40A1 TRADD AIFM2 LPCAT3 FACL4 AIM2 NCOA1 ATP7B NLRP1 TFRC DLAT GSDMD NLRP3 LIAS TLR4 FES RIPK1 FDX1 TRAF2 SLC31A1 FADD PMC7487264__F3 Activation of the PI3-kinase/Akt pathway by VacA PI3 APC CCND1 CTNNB1 PMC4736209__F2 Schematic illustration of an inflammatory IDO activation by LPS and inflammatory cytokines and possible regulatory mechanisms on transcriptional, posttranscriptional, and posttranslational level LAT BIN1 SOCS3 PMC4736209__F1 Main pathways of TRP degradation including enzymes and their potential stimuli (modified after [, , , ]) KYNU KMO AANAT PMC6039108__F3 Hematopoietic Stem Cell Gene Therapy –Progress and Lessons Learned RAD51 BRCA1 BRCA2 POLE PALB2 PARP1 PMC10374588__F4 Graphical depiction of the mechanism of classical pyroptosis pathway and non-classical pyroptosis pathway GSDMD TLR4 IL1B MYD88 PMC4201220__F2 Wnt/Beta-catenin signaling pathways and a strategy for the phenotype-based drug identification using C APC GSK3B SYS1 POP1 CTNNB1 PMC9267148__F12 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis CIAPIN1 SMAD2 SMAD4 TGFBR1 PMC9267148__F11 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis SKIL TGFB1 ZFYVE9 SKI TGFBR1 PMC4008712__F1 Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood SOCS1 ARAF MAPK1 CBL HK3 MAP2K2 GRB2 PMC4736209__F3 Possible interaction between inflammatory IDO activation and AhR-mediated effects STAT3 AHR SRC PMC11536562__F2 Alpha-KG homeostasis and m6A regulation CEBPA PFKP LDHB MYC HEL-S-26 PMC5348361__F9 Components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model BAX MAF PMC7205831__F8 Systems pharmacology reveals the mechanism of activity of Physalis alkekengi L. var. franchetii against lipopolysaccharide‐induced acute lung injury TLR4 IL1B PMC9321602__F1 Impact of DNA damage response defects in cancer cells on response to immunotherapy and radiotherapy RAD52 RAD50 RAD51 LIG1 MRE11A DNA2 FEN1 BRCA1 PAXX PALB2 BLM PARP1 PMC3814314__F5 Genome Wide Analysis Reveals Zic3 Interaction with Distal Regulatory Elements of Stage Specific Developmental Genes in Zebrafish APC TLK2 NODAL SKI PITX2 SFRP1 CTNNB1 DKK1 GSC NLK MB NKX2-5 SRC PMC11536562__F4 Promotion of ILC3 cell proliferation in m6A-dependent manner ALKBH5 NOTCH2 PMC11536562__F3 m6A modifications in fetal hematopoiesis and HSC maintenance SOX17 GATA2 BAX BAD MCL1 RNASEL MYC MAPK3 BMI1 STAT1 YTHDC1 RUNX1 YTHDF2 BCL2 FZD1 METTL3 NOTCH1 PMC5389546__F3 let-7c is predicted to target the RAS signaling pathway and miR-98 BAD RAF1 NF1 LAT NFIB NOM1 ME1 RHO PMC3814314__F6 Genome Wide Analysis Reveals Zic3 Interaction with Distal Regulatory Elements of Stage Specific Developmental Genes in Zebrafish TNC HHIP SPARC DVL2 NODAL ATOH7 PITX2 ZIC3 INVS FOXD3 PSEN2 AXIN1 TFAP2C NPY DKK2 LEF1 SMARCA4 PMC8740130__F6 Differentially Expressed lncRNAs Related to the Development of Abdominal Fat in Gushi Chickens and Their Interaction Regulatory Network LPL FACL4 SI PMC3980586__F1 Molecular Pathways: Emerging Roles of Mammalian Sirtuin SIRT7 in Cancer SIRT7 RPS14 MTOR RPS18 MYC RPS7 PMC8382834__F1 Impact of severe hypoglycemia on the heat shock and related protein response HEL-S-72p DNAJB1 UBE2G2 CLU HEL-S-102 MAPKAPK5 PPP3CA HEL-S-94n IAPP STUB1 PMC9351103__F8 Astragalus mongholicus Bunge and Curcuma aromatica Salisb. inhibits liver metastasis of colon cancer by regulating EMT via the CXCL8/CXCR2 axis and PI3K/AKT/mTOR signaling pathway CDH2 IL8RB MTOR CXCL8 IL1B PMC4033570__F5 Simplified network diagram showing the involvement of JNK and p38 in the system STAT3 OSM JAK1 TRAF6 PMC12205809__F6 Pro-inflammatory C-X-C motif chemokines (CXCs) play a crucial role in the progression and development of breast cancer in aged patients, postmenopausal women, animal models, and senescent cells CXCL9 CXCR3 CXCL12 CXCL13 FREM1 CXCL1 AGTR1 ACACA ARHA CXCL10 CXCL8 CXCL11 CXCR5 CXCR4 SOX4 PMC12205809__F5 Stroma phenotype of catabolic tumor STAT3 SHH HIF1A PMC6089851__F2 Major downstream targets of ERK1/2 in the MAPK pathway JUN FYN GRB2 SRC MYC FOS PMC4926232__F7 FGFR2IIIb-MAPK Activity Is Required for Epithelial Cell Fate Decision in the Lower Müllerian Duct BMP10 FGF7 RUNX1 BMP4 SMAD4 PMC6089851__F1 Major RAS family numbers RASD1 RAN ARFRP1 ARF1 ARF6 HEL-S-42 RIT2 REM1 ARL1 RND2 ARF5 ARL16 ARHH DIRAS1 RHOF RASL11A ARL5C ARL14 ARL4D RHOBTB1 ARL9 RASL12 ARL13B RASL10A RHEBL1 RHOV RAP2C RHEB RAP1A ERAS CDC42 ARHG GEM DIRAS2 RASL11B RHO RAP2B RAC3 REM2 DIRAS3 RHOBTB2 NKIRAS1 RND1 NKIRAS2 ARL11 RHOBTB3 ARL2 RERG RAC1 RHOU RAP2A RASL10B ARL15 ARF3 ARF4 RRAS ARL6 ARL3 RASD2 RRAS2 TRIM23 PMC9452894__F3 Chemistry and efficacy benefits of polysaccharides from Atractylodes macrocephala Koidz BAX GSK3B CTNNB1 PMC2455793__F1 Interaction between two known Egr1 target genes, PTEN and fibronectin achieves a delicate balance between attachment and apoptosis of detached cells (anoikis) BAD FAS EGR1 PTEN CTNNB1 PMC6089851__F3 Activation and feedback regulation of the MAPK pathway DUSP5 HBEGF TGFA FYN MCL1 BCL2 GRB2 SRC CCND1 PMC9138619__F3A Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids CCL27 CXCR3 LTA CSF1 OSM CCR2 EPO SOCS3 CXCL3 GSDMD FLT4 EPOR CCR7 MMP3 TNFRSF12A IRF9 PLG IRF7 TNF CXCL10 FOS CXCL11 CXCR4 TWEAK EDAR CCL20 VEGFC CXCL12 NFKB2 RELB MAP3K14 CSF3 CORT BTK IL18 PDGFD JUN TNLG2A CCL11 SELE OSTN BLNK VEGFD CXCL2 PTGS2 IL6 TNLG2B BMP2 JAK1 LYN TNLG7C PMC8888757__F8 Proposed simplified model of ADAP1-mediated T cell signaling stimulation leading to latent HIV-1 reactivation ALB JUN KRAS FOS PMC9027133__F5 Research Status of the Orphan G Protein Coupled Receptor 158 and Future Perspectives CAV2 RGS7 GPC4 GPR158 BDNF PMC9118275__F3 MicroRNA-96: A therapeutic and diagnostic tumor marker SFRP4 APC GSK3B NPTX2 CTNNB1 PMC11898300__F5 Diagram of tumor cell biomechanical perception, conduction, and effect mechanism PIEZO1 HEL-S-11 RHO MTOR PMC8243062__F3 NRF2 signalling pathway and antioxidant therapeutic approaches TBK1 BACH1 KEAP1 BRCA1 GSK3B MAF PMC8806153__F3 Metabolism of memory CD8+ T cell differentiation RHEB TSC2 FAS TSC1 OPA1 AQP9 PMC9340488__F4 Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions TMPRSS2 CXCL9 STAT3 TRADD IRF9 RELB IRF7 IL6 CXCL10 CCL2 IRAK4 MYD88 STAT1 ADAM17 TLR3 TLR4 TLR8 TLR7 TYK2 ACE2 IL1B PMC9340488__F2 Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions TMPRSS2 TLR9 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR7 ACE2 PMC3328890__F1 ROS-dependent and -independent apoptosis induced by particulate pollutants BAX BAD MCL1 AHR MB PMC5891223__F5 Epidermal Growth Factor Receptor Signaling to the MAPK Pathway Bypasses RAS in Pancreatic Cancer Cells CDC42 EGF PAK1 EGFR PMC8517597__F2 Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment CTSK CXCL10 TNF IMPACT PMC2949087__F5 Mitochondria and neuroplasticity TF PINK1 LRRK2 APP BDNF HTT PMC6876280__F1 An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer SUZ12 EED EZH2 PMC1890373__F2 Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands ATR CD36 HEL-S-162eP HEL-S-5 PMC7912608__F5 Diversity of NO functioning in cancer PTN COX2 HIF1A CXCR4 CTNNB1 PMC8429462__F8 Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine TBK1 IRF3 DDC PMC5448443__F1 Amyloidogenic and non-amyloidogenic processing of the APP EGF NGF BACE1 APP GPR3 IL8RB PMC4450051__F4 Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex CD40 CD80 TIRAP ELL CTSK TLR9 CD14 CPO IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 RAE1 LBP IL1B FADD PMC8113849__F1 Estrogen and estrogen receptor-mediated pathways in thyroid cancer TRIM16 RAF1 PI3 EGFR IQGAP1 WNT1 PTEN MTOR NOX4 CTNNB1 PMC8621031__F2 Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models SMAD2 SIRT1 PMC4904902__F1 AMBRA1, a novel mitophagy receptor PINK1 AMBRA1 BCL2 PMC4560339__F1 Multimodality targeting of MM in the context of the BM microenvironment SLAMF7 BRD4 CXCL12 HGF IGF1 PDC VEGFA MYC PMC5149521__F3 PKB associated signal transduction pathways BAD CAD GSK3B MDM2 MTOR EIF4E PMC9578220__F6 Novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients HLA-DMB TNFRSF18 TNFRSF4 HLA-G CD40LG BTNL9 CD47 PMC6103702__F5 Representative cell cycle pathway between PCOS arrested and non-arrested 2-cell embryos RAD21 CDK7 PCNA CDC45 SMAD2 SMAD4 CDK2 ORC1L ORC3 SKP2 ORC2 PMC7662147__F2 Life cycle and cleavage of SARS-CoV-2 and ENaC in airway cells TMPRSS2 FURIN CAP1 ACE2 PMC5751286__F2 Schematic view of (A) the NFKB signaling pathway and (B) the JAK-STAT signaling pathway that contribute to the pathogenesis of psoriasis and its novel targeting molecules IL19 MAVS IL24 IL6 PMC4230721__F3 Compounds used as anti-fibrotic therapies in other organs and their mode of action HGF MTOR PMC7576264__F9 Rab27A promotes ROS production and apoptosis via suppressing miR‐124‐3p and increasing STAT3/RelA pathway in inflammatory colonic cells STAT3 RAB27A RELA PMC2605487__F2 Signalling pathways involved in the induction of astrocyte specification/differentiation STAT3 CNTF SMAD1 GFAP LIF SMAD4 PMC4578651__F4 Chymomyza costata exposed to Long Day (LD), Short Day (SD) and Transfer (T) from LD to SD photoperiodic conditions AGO2 C13orf34 E2F2 DPY30 MYT1 PMC7962892__F1 TNFAlpha-induced signaling pathway of cell survival, apoptosis and necroptosis TRADD MLKL TRAF5 TRAF2 FADD PMC8530315__F7 VitD3 effects in D3-MDMs during DENV-2 infection NR1i1 CYP27B1 STAT1 TLR3 STAT2 IRF9 TLR9 TLR7 OAS1 PMC6488436__F1 Sphingolipid metabolism CERS3 CERS5 CERK SMS CERS1 tmp_locus_29 CERS2 CERS6 PMC5816341__F1 Schematic diagram of the three pathways of the complement system, highlighting the upregulator (properdin) and downregulator (factor H) of the alternative pathway C6 HEL-S-62p C2 C1S TSR3 TSR2 TSR1 CS C4A PMC8050350__F5 Metabolic Signature of Autoreactive T cells in Rheumatoid Arthritis SLC5A12 SUCLG2 PMC7156472__F6 Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer SHH MVD PMC3377280__F7 Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition CDC2 RAD51 WEE1 PLK1 PMC9614365__F1 Metabolic requirements of Th17 cells and of B cells: Regulation and defects in health and in inflammatory diseases IFNG GLS FOXP3 LEF1 PMC7411130__F3 Regulators of the complement pathway C6 CD59 C7 HEL-S-62p C2 VTN C4B_2 CR1 PMC6938958__F8 Identification of Regulatory Modules That Stratify Lupus Disease Mechanism through Integrating Multi-Omics Data MAX TF SOCS1 RAD51 STAT2 PSMB8 IRF9 MNT PSMA4 PSMB2 MYC E2F5 BLM RAD51B IFIT5 STAT1 E2F4 ELF1 CDKN1B ISG15 TYK2 PMC2136409__F7 Genetic and epigenetic mechanisms of gene regulation during lens development MAF GRB2 FGF8 FGF2 PMC3253704__F1 Prominent signaling pathways involved with PDAC tumoral compartment and stromal compartment crosstalk SHH SMO KRAS PMC7913053__F1 Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis DKC1 TERT POT1 NOX4 TPP1 PMC3232381__F1 Tumour necrosis factor receptor 1 (TNFR1) and its signalling pathways TRADD TRAF2 FADD PMC4742793__F9 Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin LRP5 WNT7A LRP6 PMC5624958__F7 Schematic diagram of the proposed mechanism by which OCA may modulate the IL-6/Jak-2/STAT3 signalling pathway in HCC cells STAT3 SOCS3 IL1B PMC6939459__F10 Conceptual models of mitochondrial metabolite transport and the consequence of metabolic perturbations on Th1 cell activation TH FAS MAL CIT PMC8383068__F1 Proteomics Mapping of the ISGylation Landscape in Innate Immunity IFNGR2 UBA7 IFNGR1 UBE2L6 IFNAR2 IRF9 USP18 IFNAR1 ISG15 JAK1 SRC PMC6933925__F2 Possible rational combination treatments for HH/GLI-associated cancers simultaneously targeting HH/GLI and HH-regulated immunosuppressive and tumor-promoting signals CCL23 IFNG STAT3 IL10 CCR2 SHH IL11 IL6 IL1B PMC3562341__F4 Accumulation of Splice Variants and Transcripts in Response to PI3K Inhibition in T Cells ZAP70 TEC FYN SHB LAT ITK GRB2 LCK PMC5908737__F3 MUC1-C ACTIVATES POLYCOMB REPRESSIVE COMPLEXES AND DOWNREGULATES TUMOR SUPPRESSOR GENES IN HUMAN CANCER CELLS BMI1 TG MYC PMC6940409__F2 Photic- and non-photic-responsive MAPK signaling pathways in the brain PMC5416959__F10 RFC-PCNA complex inhibiting cell proliferation RFC4 RFC1 RFC2 PCNA RXRA RFC3 PMC9539821__F2 Epigenetic factors in breast cancer therapy DKK3 APC GSK3B CTNNB1 PMC3142564__F1 Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer LPA BAD GSK3B PTEN MDM2 MTOR RAC1 PMC6625911__F1 CaMKK2 and advanced glycation endproducts (AGEs) within the bone microenvironment CEBPA ALPL CAMKK2 SOX9 TLR4 BMP2 CTSK NFATC1 RUNX2 CEBPB ACP5 PMC2657945__F1 The TSC-mTOR signaling RHEB TSC2 TSC1 SGK1 PTEN PMC7983599__F1 Effect of Thyroid Hormones on Adipose Tissue Flexibility TRO TRH CPT1A PMC2657945__F2 Regulation of the mTORC1 pathway by two distinct small GTPases RHEB TSC2 TSC1 PMC6497036__F10 Proposed mode of action for RHOA to maintain TE characteristics in the expanding blastocyst AMOT ARHA NF2 PMC9138619__F2A Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids CXCR3 TH VEGFC LTA FAS LTBR OSM CCR2 CCR3 CCL2 MAPK14 CORT NGF BTK BCL10 FLT4 EPOR NOD2 CAST CSF2 SELE OSTN LIF PLG BLNK IRF1 CXCL2 CXCL10 TNLG2B LTB TNFSF14 CXCL11 RELA BMP2 IL8RB LYN REL CCL20 TRAF2 TNLG7C PMC8273970__F10 EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway AGO2 ASPH ZEB2 VEGFA ONECUT2 PMC5859524__F1 Regulation of the cell cycle BAX ATR ATM PMC2424193__F6 Chemical Rescue of ΔF508-CFTR Mimics Genetic Repair in Cystic Fibrosis Bronchial Epithelial Cells STAT3 IL10 HEL-S-269 IKBKE IL4 IL6 TNF TRAF6 IKBKG IFNG HSPD1 NFKB1 HSPA4 CFTR TRAF2 PMC3539910__F2 Carcinogenesis of colorectal cancer cells and role of different miRNAs in cancer pathways BAX CASP9 DCC BAD EGFR SMAD2 APC CASP3 SMAD4 PTEN CCND1 CTNNB1 PMC8678087__F1 Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration PAX3 MYOG MYF5 PAX7 PMC4270317__F5 Cell cycle pathway CDK7 MALL F5 CDK2 FAP PMC11994677__F1 Crosstalk between KTRM and renal cellular networks STAT3 CSF2 S100A8 TNF S100A9 MYD88 PMC5345622__F1 Occurrence and regulatory mechanisms of ferroptosis in a cell TF IREB2 ACSF2 IPP GPX4 CS PMC7512067__F6 Summary diagram outlines the working mechanisms of oridonin in FaDu cells CDH2 WNT3 CTNNB1 PMC4780413__F6 Reduced PARP1 as a Serum Biomarker for Graft Rejection in Kidney Transplantation GPHN MCL1 GSK3B AIRE MAPK3 SYCP3 IFNG HMOX1 DLGAP1 CCNE1 RBBP4 PDPK1 NEUROG1 MAPK1 SRP54 NOS2 TNFSF6 ITGB3 TNF STXBP5 ATF3 IGF1 PSEN2 ZNF423 BCL2 CDKN1C WASF1 PSAP CYBB CP RAP1GAP FAS HGF TGFB1 LAT TSNAX CTNNB1 IL2 ATM IL1B ACHE MATK IL4 PTGS2 IL6 TFF3 PARP1 NR3C2 IKBKB DDIT3 EP300 NEK3 LYN PDCL FADD SELP PMC9027478__F1 Notch signaling network in muscle stem cells during development, homeostasis, and disease DLL4 PAX7 RBPJ PMC2637474__F7 Hypothetical pathway involved in general cerebellum-mediated motor learning GC CS DCN PMC4412130__F1 Eukaryotic mechanisms that manage replication– transcription conflicts TREX2 PIF1 ATR MRC1 PMC12205809__F4 Interleukin (IL)-10/11/tumor necrosis factor (TNF) and transforming growth factor (TGF) pro-inflammatory cytokines play a role in breast cancer in postmenopausal women and senescence cells, as shown in the illustration STAT3 SP1 SDC1 IL11RA TNF PMC12205809__F3 Pro-inflammatory cytokines (interleukins/ILs) play a role in aged/postmenopausal breast cancer women or animal model/senescence cells, as depicted in the illustration STAT3 STAT1 CGAS KDM2A PMC7967218__F2 Histone acetylation regulates genes involved in cancer progression ST14 BMI1 TGFBR2 EPCAM HDAC1 ESRP1 FOXF1 SMAD2 SMO RAB25 PMC4323104__F7 Clinical Proteomics Identifies Urinary CD14 as a Potential Biomarker for Diagnosis of Stable Coronary Artery Disease CD59 LGALS8 FUCA1 SERPINA1 GLIPR2 PKN2 CD14 APOH F2 CMTM8 HAS3 VASN GLB1 PMC12065104__F5 Molecular and signaling changes between a normal melanocyte and a melanocytic melanocyte IFNG STAT1 CDK6 NF1 IRF1 PTEN MDM2 JAK1 CDK4 PMC5350610__F3 The consequences of perturbation of CUL4CRBN E3 ligase function DDB1 CRBN PMC3618441__F1 Membrane-initiated Actions of Estradiol that Regulate Reproduction, Energy Balance and Body Temperature STAT3 PLCG1 PMC7160552__F3 Recent advances in unraveling the molecular mechanisms and functions of HOXA11-AS in human cancers and other diseases MMP16 HOXA2 PRSS8 KLF2 GC EZH2 NODAL CTNNB1 PMC7160552__F2 Schematic diagram that introduces in detail the molecular mechanisms, clinical values and cell phenotypes affected by HOXA11-AS in different tumor types, including (A) NSCLC, (B) HCC, (C) glioma, (D) CC, and (E) BC LATS1 DUSP5 STAT3 HOXA2 DOCK8 PADI2 CDK2 EZH2 PDE4D CDK4 PMC8509647__F3 Pathogenesis of IgA Nephropathy: Current Understanding and Implications for Development of Disease-Specific Treatment C6 CD59 CFHR4 FH C7 CFHR5 HEL-S-62p CFHR1 C4A CR1 CFHR3 C2 CFHR2 C9 C4B_2 PMC7853511__F8 Cross-effect of TRPV1 and EP3 receptor on coughs and bronchopulmonary C-neural activities NTS APC TRPV1 PMC5299705__F7 The regulatory network of HOTAIRM1 involved in the autophagy pathway and the degradation of PML-RARA DRAM2 ULK1 PMC9576592__F7 Schematic model depicting the functions of SNHG5 during the proliferation and cancer stem cell-like properties of HCC CD44 WNT3A SOX2 WNT1 TCF4 WNT10A CCND1 CTNNB1 PMC2257939__F2 Bimodal genes highlighted in KEGG ECM-receptor interaction diagram CD44 VWF CD36 CHAD CD47 PMC7843937__F8 An overview of pathways involved in mediating Cor and DDP-induced cellular effects CASP3 MTOR CCND1 PMC7768751__F1 Role of Diet and Phospholipase D enzyme in the complex network of choline pathways and Choline-Mediated 1C metabolism PEMT PC PMC7456829__F4 Pathways of anti-TNF monoclonal antibodies action in Crohn's disease (CD) FAS TNFRSF1B ADAM17 FCGR3A PMC7037830__F3 Binding mechanism of LPS for TLR4 activation TLR4 CD14 LBP PMC4536973__F1 Physiopathological actions of periostin activation PI3 EGFR SMAD2 BMP2 WNT3 PMC9312508__F10 Host-Genome Similarity Characterizes the Adaption of SARS-CoV-2 to Humans TBK1 MAVS TLR3 STAT2 TANK TLR7 TRAF3 JAK1 TRAF6 TYK2 MYD88 PMC9329783__F1 Sweet Taste Signaling: The Core Pathways and Regulatory Mechanisms TRPM5 PLCB2 CALHM1 PMC4423042__F6 Cartoon representing LPA-activated signaling cascades that regulate OHC motility, as suggested by our results and previous studies (in black font), as well as potential mediators and interactions that require confirmation (gray font) LPA LIMK1 ARHA PMC7691485__F3 Basic components and rough characteristics of each indicated signaling pathway in relation to primary cilia ADRBK1 TGFBR2 SUFU EGFR SMAD2 PDGFRA SMAD4 GLA SMO PMC5789373__F2 Cross-talk of mTOR with other signaling pathways RHEB TSC2 TSC1 PTEN MDM2 SKI PMC7770202__F1 Signaling pathways of interest in the peripheral and central nociceptive pathway TRPV1 ATF3 NGF TRPA1 COX2 NFKB1 RAMP1 RELA TACR1 NPY CALCA BDNF IL1B PMC9329783__F3 Sweet Taste Signaling: The Core Pathways and Regulatory Mechanisms STAT3 TRPM5 PLCB2 CALHM1 PMC7770202__F8 Response to aging in the mouse somatosensory nervous system ATF3 TRPA1 RAMP1 NFKB1 RELA NPY CALCA BDNF PMC6613841__F8 Proposed mechanisms underlying the regulation of innate immune response by influenza virus H5N1/HM M2 protein MAVS IRF3 IRF7 ATG5 PMC2984239__F5 Merged network pathway analysis of proteins involved in cellular assembly and organization, cellular compromise, and protein folding that were identified in cytoplasmic fraction PHB2 NR2A1 RAB18 TRMT112 WNT10A TRMT1 PMC6192633__F8 GPR108 works as a dual functional regulator to balance the TLR-triggered immune response TIRAP TLR4 GPR108 TRAF6 MYD88 PMC4350884__F8 EtOH and INK128 impact on the mTOR pathway and cellular response RICTOR MTOR EIF4E PMC11215396__F1 CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis MPL HEL-S-99n EPOR PMC6722206__F1 miRNAs orchestrate T cell metabolic reprogramming MTOR CPT1A PMC6166692__F2 Redox-Sensitive Innate Immune Pathways During Macrophage Activation in Type 1 Diabetes IFNG STAT1 SUMO4 JAK1 MYD88 PMC6365085__F9 MicroRNA-223 attenuates LPS-induced inflammation in acute lung injury model via the NLRP3 inflammasome NLRP3 TLR4 RHOB IL1B PMC9589179__F7 Mining of transcriptome identifies CD109 and LRP12 as possible biomarkers and deregulation mechanism of T cell receptor pathway in Acute Myeloid Leukemia CD96 CD226 CD80 TIGIT CEACAM1 FGL1 APC BTLA LAG3 PMC2921074__F1 Modulating immune function and controlling inflammation STAT3 HMGB1 TNF PMC8257046__F8 SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects ROCK1 DVL2 ARHA RAC1 PMC4227186__F6 TCDD induced HIF-1A molecular signaling UCP2 TFAM PIGF AHR VEGFA PMC5421298__F6 Gene expression changes in the TGFB signaling pathway SMAD1 INHBC BMPR1A SMAD2 ZFYVE9 SMAD4 CDKN2B MYC TGFBR1 BAMBI ACVR1B E2F4 FST NOG DCN BMPR2 THBS1 ROCK2 SP1 TFDP1 ARHA TNF RBL1 SMURF1 ACVR1 RPS6KB1 BMP2 SKP1 CREBBP PMC5421298__F5 Gene expression changes in the Wnt/Beta-catenin signaling pathway SOX17 JUN FZD10 GSK3B SMAD4 NR1C2 DVL2 ARHA MYC BAMBI INVS BTRC PORCN CCND2 RUVBL1 NOTUM AXIN1 PRKCA TP63 CREBBP NFATC3 PLCB3 CAMK2G PMC7037830__F4 Illustration of TLR4 signaling pathway TBK1 MAP3K7IP1 TIRAP TLR4 IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC4859668__F3 DDX3 is involved in Wnt/Beta-catenin pathway BCL9 MMP7 APC LRP5 LRP6 CCND1 CTNNB1 PMC10472599__F8 Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML CXCL12 CDK6 CD69 MSC MTOR CXCR4 CCND1 SET CD34 PMC2681728__F8 Proposed model of the role of p47 in E FYN PCGF5 PMC8469604__F6 Uncovering the Metabolic and Stress Responses of Human Embryonic Stem Cells to FTH1 Gene Silencing UCP2 HMOX1 FTL KEAP1 NQO1 HEL-S-44 PMC2933544__F3 Proposed model of epidermal growth factor receptor (EGFR) aberrant activation and trafficking in the setting of cigarette smoke (CS) EGF EGFR CS GRB2 PMC4464707__F4 Integrated regulatory graph was constructed as a prediction for the regulatory pathway of IMP metabolism CEBPE THBS1 CD2 BPI PTEN HEL-S-70p MNDA CDX2 ETV6 HSPA2 HSPA4 GABPA GJA1 GDE1 PMC4078307__F1 Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival TH PNMT DBH DDC PMC7304430__F12 Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research TRADD TRAF2 IRS1 PMC3726197__F1 Signaling axis exploited in the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) mutant mouse model of prostate tumorigenesis BAD PTEN MTOR PMC5869686__F5 Representation of the TCA cycle and glyoxylate shunt pathway SDHD SDHA SDHB SDHC PMC6500618__F7 A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis MAPK14 JUN MCL1 RELA CASP3 TNF IL23A PMC9653866__F2 BTN3A: A Promising Immune Checkpoint for Cancer Prognosis and Treatment IFNG STAT3 APC IL4 BTN3A3 PMC4160455__F1 Multiple mechanisms lead to the development of PPCM in mice STAT3 ERBB4 PRL NRAS PMC11121000__F1 Insights into Salinity Tolerance in Wheat CLC PMC5349926__F2 Discovery and replication of microRNAs for breast cancer risk using genome-wide profiling KLF4 TBK1 GPR37 MCL1 PIK3R1 PTEN BBC3 LAMC1 PLK1 DUSP2 DIRAS3 CCKBR CDK6 PRC1 BMF MAPK12 MDM2 CRP DNMT3B SP1 BCL2L11 KRAS FOS TPRN FRAT2 FOXO3A BCL2 PMC9041553__F2 Ex Vivo Test for Measuring Complement Attack on Endothelial Cells: From Research to Bedside C6 FH C7 CAD HEL-S-62p C9 PLG VTN CS CR1 CP PMC8393646__F9 Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2 HEL-S-51e PMC3110099__F14 Schematic diagram to show that knockdown of Akt1 leads to upregulation of Akt2 in response to oxidative stress and its regulation of oxidative-stress-induced apoptosis through three pathways GSK3B MDM2 PMC4324359__F2 Differentially expressed gene enrichment of the top scored pathway maps BAX DNAJC3 JUN ATF4 XBP1 TRAF2 PMC5601305__F1 Mechanisms used by Toxoplasma gondii, type I strain, to modulate mainly immune system at its favor IFNG NOS2 EGF FAS TGFB1 IDO1 PMC7890269__F7 Proposed model NR3A2 TFEB PMC7457135__F1 Protective and detrimental roles of mitochondrial reactive oxygen species (mtROS) during infection ECSIT GABARAP SIRT3 TLR1 MAVS NLRP3 KEAP1 TLR4 TIPARP MTOR TRAF6 TNF PMC8455891__F1 Neurodevelopmental Disorders (NDD) Caused by Genomic Alterations of the Ubiquitin-Proteasome System (UPS): the Possible Contribution of Immune Dysregulation to Disease Pathogenesis ATXN3 STAMBP UBE3A UFC1 PSMD12 FBXO31 ITCH FBXW11 PARK2 TRIM2 NHLRC1 LRSAM1 HECW2 RNF170 HEL-S-305 HUWE1 TRIP12 STUB1 FBXO11 RHOBTB2 RNF125 USP27X MID1 RNF168 TRIM37 USP18 CRBN KCTD13 HERC1 MAGEL2 USP9X IRF2BPL FBXO28 OTUD7A UBR7 HACE1 CUL7 CUL4B USP22 PMC10531449__F3 Transcriptomics of Canine Inflammatory Mammary Cancer Treated with Empty Cowpea Mosaic Virus Implicates Neutrophils in Anti-Tumor Immunity TH MAFK TAB3 COIL ELL LCN2 FADD PMC3243339__F8 Depiction of how D1 and c-Myc proteins regulate CDDP-induced cell death, with arrow indicating induction and hyphen (-|) indicating inhibition BIRC5 NFKB1 RELA RELB PMC3567827__F1 Hh signal transduction in Drosophila and mammalian systems ADRBK1 GPC4 SPOP KIF7 SUFU GPC6 SMO GPC3 GAS1 PMC11943624__F3 Key metabolic pathway components and targets for nanomedicine-based targeting (rectangles represent components, rounded rectangles represent enzymes, and dashed lines and multiple arrows indicate omitted multistep reactions) FAS CAD HMGCR HEL-S-133P CD36 NPC1L1 DHFR IMPDH1 IMPDH2 HEL-S-70p DHODH PMC7773645__F1 NLRP3 inflammasome pathway associated with potential blockade sites of various pharmacological inhibitors to treat fibrosis NLRP3 TXNIP CD36 IL16 TLR4 MNT MTOR NOX4 IRS1 PMC8392679__F3 Hidden Treasures: Macrophage Long Non-Coding RNAs in Lung Cancer Progression NECAB3 WNT3A ARG1 PTEN TCF4 MDM2 CD163 CTNNB1 GATA3 PMC2118167__F7 Proposed model for the intersection of innate and adaptive immunity during polysaccharide-induced abscess formation in the peritoneal cavity STAT4 PMC7244458__F2 Mast cells (MCs) respond to a wide range of pathologic and environmental stimuli owing to the expression of toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLRs) CXCR3 SYK CXCR6 CCR5 CCR3 CXCR1 FYN TLR3 CCR7 CCR4 TLR7 LYN IL8RB GRB2 GAB2 PMC10991391__F3 TGFB influences cellular metabolism through canonical and non-canonical pathways PPARG PHGDH SMAD2 SMAD4 MTOR HEL-S-51e PMC10991391__F5 Cellular metabolism and myofibroblast contraction cascades PHGDH SMAD2 SMAD4 RHO MTOR HEL-S-51e PMC10991391__F2 Integrin receptors influence cellular metabolism through ECM sensing LPIN1 RHO MTOR TRIM21 PMC8801022__F2 Mitophagy during oocyte aging in human, mouse, and Drosophila: implications for oocyte quality and mitochondrial disease PINK1 BCL2 FUNDC1 PMC7794837__F1 Altered Ca2+signaling in T cells during aging—impact of ion channel expression and function ZAP70 TRPM7 TRPM2 ORAI1 IL2 FOXP3 PMC3160099__F7 Pathways that control the onset of adulthood and the terminal differentiation of specific cell lineages are conserved from C LIN28B SF1 LHB c-fgr PMC5496266__F6 The roles of microRNA families in hepatic fibrosis TGFBR2 HGF CCNE1 TGFBR1 PMC34619__F2 Signaling to eukaryotic translation initiation and elongation factors EEF2K EIF4B EEF2 MTOR PMC10141515__F6 Differentially expressed proteins of the serine metabolic pathway in ovarian cancer PHGDH PSAT1 HEL-S-51e PSPH PMC10572723__F3 Interacting compounds and PTMs of PPARG that regulate its function in the endothelium FOXO1 EGFR PIAS1 CTNNB1 PMC12017852__F5 Signaling pathways of RGS12 in tumor RGS12 MNX1 MYCBP2 PTEN ARHA MTOR PMC12017852__F4 Relevant signaling pathways of RGS12 in arthritis RGS12 TNF PMC5496266__F2 The roles of microRNA families in hepatic fibrosis LOX IGF1 PDGFC AKT3 PMC9030597__F1 Pathway-Based Genetic Score for Oxidative Stress: An Indicator of Host Vulnerability to Phthalate-Associated Adverse Neurodevelopment SP1 NFKB1 CYP1A1 GPX1 NOX4 FOS HEL-S-44 PMC8270011__F2 Lower Extremity Vein Dysfunction in Chronic Venous Disease and Implications in Management of Varicose Veins C6 HEL-S-62p C2 VCAM1 PMC5504108__F2 Therapeutic targets that regulate YAP/Hippo activity in mesothelioma LATS1 CDC2 ROCK2 ROCK1 RHO NF2 CDK9 PMC7938710__F3 Network analysis using the Ingenuity®Pathway Analysis (IPA®) software program CASP9 FGD2 TSG101 GPR55 NCOA7 ADGRF5 ADGRE2 SSTR4 RSPH6A ALDOB DRD2 DTYMK GPR143 GPR137 GALR3 UNK PMC8438004__F1 St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity TG GFAP PMC3115327__F3 Scheme of the signal transduction pathway in response to DNA damage ATRIP RAD1 ATM GADD45A PMC4717889__F1 TLRs play critical roles in gastrointestinal inflammatory disorders at the mucosa TBK1 JUN TIRAP EGFR TLR9 CD14 SIGIRR IRF3 TRAF6 RORA CTNNB1 MYD88 TLR1 TLR3 TLR4 TLR7 PMC4598795__F6 Cd-elevated genes associated with mitochondrial oxidative phosphorylation pathway that occurs in electron transport system NDUFB5 ZNF183 NDUFB3 NDUFS1 SDHAF2 PMC5982776__F4 The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival RFWD2 BAX ATR GAL FAS SIAH1 PERP PTEN GNAL MTOR GDA TSC2 GFAP IGF1 PIGA USP4 USP12 USP46 ATM RAX PSAP APAF1 PMC5245710__F6 Human SRMAtlas: A resource of targeted assays to quantify the complete human proteome HMGN2 PNN HNRPA3 PCNA RRM1 NCAPG RRM2 PRIM1 LMNB2 KIF23 MKI67 MCM7 NUSAP1 PRKDC SRM IPO5 SHMT1 MCM5 SPAG5 RFC3 MCM2 UHRF1 TOP2A PMC8431517__F4 Network Pharmacology Study on Morus alba L. Leaves: Pivotal Functions of Bioactives on RAS Signaling Pathway and Its Associated Target Proteins against Gout PPARG EBP NR1C2 DHODH RORA PLA2G2A PNP CDA SHBG SPHK2 RARB NR3A2 TLR4 CHEK2 PRKCA PARP2 TYMP DNMT3B NR1i1 CYP17A1 PLG TRPV1 NR1C1 HEL-S-162eP HSD11B2 ADA PMC3930975__F1 The unfolded protein response pathway ATF4 XBP1 PMC7793096__F3 Carbon monoxide-induced phenotypic switch of macrophages CD80 IL10 PMC8772992__F3 Preventive Effects of Beta-Cryptoxanthin, a Potent Antioxidant and Provitamin A Carotenoid, on Lifestyle-Related Diseases—A Central Focus on Its Effects on Non-Alcoholic Fatty Liver Disease (NAFLD) ADH1C CYP26B1 HEL-S-117 DGAT1 HEL-S-53e LRAT RBP4 RDH11 AKR1B10 ADH1A ALDH1A3 RARB DGAT2 CRABP2 CRABP1 DHRS4 RDH10 RDH5 ALDH1A2 RXRB DHRS3 CYP26A1 PMC4934035__F5 The pathway of LysoPC16:0 LPA PC PMC5617461__F9 Overexpression of stathmin plays a pivotal role in the metastasis of esophageal squamous cell carcinoma JUN ITGB1 ITGA1 KRT16 GBP1 KRT13 FOS PMC3666557__F2 Endoplasmic Reticulum and the Unfolded Protein Response: Dynamics and Metabolic Integration ATF4 EIF2A PMC8269281__F1 Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis GRPR NGF TSLP ITCH IL33 PMC11039397__GA1 StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR-c-src-NFKB/p-ERK MAPK-NFATc1 signaling pathway DCSTAMP CTSK AIP ATP6V0D2 AHR NFATC1 ACP5 PMC6001649__F2 Salivary Exosomes: Emerging Roles in Systemic Disease PTEN HEL-S-276 PMC7564398__F1 A high-fat diet (HFD) and chronic cannabidiol (CBD) administration on the sphingolipid metabolic pathway in rat myocytes UGCG SPHK2 tmp_locus_29 SPTLC1 PMC5846707__F1 Signal transduction by TGFBs and BMPs TGFB and BMP ligands induce formation of heteromeric complex between specific Type II and Type I receptors TF LIMK1 SMAD4 RHO DROSHA PMC8614664__F2 Animal Models of Coenzyme Q Deficiency: Mechanistic and Translational Learnings COQ8B COQ10A COQ7 PDSS1 PARL COQ4 COQ3 COQ2 COQ9 COQ6 PMC6041399__F1 Schematic presentation of JNK signaling pathway in cerebral ischemia/reperfusion injury BAX BAD FAS HRK PMC3966557__F1 RGS proteins in the regulation of GPCR, PTH, and Wnt signaling pathways during bone remodeling CASR RGS2 RGS12 RGS18 RGS5 RGS10 NFATC1 PTH AXIN2 CTNNB1 PMC11657104__F1 Biosynthetic pathway of L-Homoserine in E GALP NR1A2 THRA ASPA CIT PMC4803542__F1 Monogenic Mouse Models of Autism Spectrum Disorders: Common Mechanisms and Missing Links RHEB UBE3A PTEN ARC BDNF PMC2808458__F2 Toll-like receptor signaling in cell proliferation and survival IL10 IRF7 MTOR MYD88 PMC3827118__F2 Hh signaling in mammals SUFU PTCH1 SMO PMC2808458__F1 Toll-like receptor signaling in cell proliferation and survival TBK1 IRAK1 IRF3 TRAF6 IRAK4 MYD88 PMC4414131__F2 Multiple cellular functions of the oncoprotein Golgi phosphoprotein 3 OGT GOLPH3 VPS35 MAJN MTOR PMC3827118__F1 Wnt-dependent pathway responses PORCN APC ROR2 LRP5 LRP6 CTNNB1 PMC12219892__F10 Pathways associated with DOX-induced cardiotoxicity HMGB1 IL6 MTOR SIRT1 PMC7142847__F1 Metabolic reprogramming in triple-negative breast cancer (TNBC) HEL107 GLS PGM3 PHGDH F2 HEL-S-162eP PSAT1 ME1 ASNS HEL-S-30 GPT PMC10141515__F5 Differentially expressed proteins of the glutamine metabolic pathway in ovarian cancer ASS1 ASL GLS BCAT1 PMC5535862__F1 Schematic model proposing a differentiated cell as the cell of origin of skin squamous cell carcinoma (SCC) GRHL3 CIC PTEN MTOR PMC9240209__F2 Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic Factors TBK1 MAVS TLR3 IRF3 PMC2945552__F11 Proposed signaling pathway modulated by TH2-3 in LPS-induced RAW264.7 cells COX2 CD14 PDE4D MYD88 PMC6636823__F1 Canonical Wnt signaling pathway APC GSK3B LRP5 LRP6 PMC7097090__F3 Counter-regulatory renin–angiotensin system in cardiovascular disease SMAD2 PMC10474042__F2 Calcium signaling in efferocytosis ORAI1 STIM1 MCU CRBN MERTK PMC9502831__F1 Modulators of Wnt Signaling Pathway Implied in Dentin Pulp Complex Engineering: A Literature Review APC LRP5 SMAD6 LRP6 CTNNB1 PMC7878452__F1 Glucose metabolism in the brain HEL-S-162eP PMC8847181__F2 Functional and Therapeutic Significance of Tumor-Associated Macrophages in Colorectal Cancer STAT3 FOXQ1 JAK3 RELA MTOR TNF CXCL8 FERMT2 PMC4186533__F6 Src family kinases in Gq- and Gi-coupled receptor signaling FYN HEL-S-11 LYN ARHA PMC8664592__F8 HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5 TBK1 MAVS TANK IRF3 PMC7552046__F6 Natural 5′ terminally deleted group-B enterovirus RNA forms can modulate type I interferon signaling pathway activation MAVS IFNAR2 IFNAR1 IRF3 IRF7 CHAD PMC7552046__F5 Group-B enterovirus proteinase activities impair type 1 signaling pathway activation in infected cells TBK1 MAVS TLR3 TAB3 IRF3 IRF7 TRAF6 PMC7590177__F1 Detection of poxviruses by anti-viral pattern recognition receptors (PRRs) leads to the activation of IRFs TBK1 TBKBP1 CGAS MAVS TANK TLR9 IRF3 MTOR TRAF3 TRAF6 MYD88 TLR3 TLR4 TLR8 TLR7 IL1B PMC7136464__F1 IFN-I and IFN-II signaling STAT1 IFNGR2 IFNGR1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC4157144__F3 L-Serine Biosynthesis PathwayDe novo biosynthesis of serine is crucial to provide the organism with sufficient levels of this amino acid PHGDH PSAT1 PSPH PMC8199451__F1 Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What Can Be Learned from Other Coronaviruses ATF4 EIF2A XBP1 PMC8042134__F3 Factors produced in the obese breast microenvironment contribute to the growth of breast cancer STAT3 MTOR TNF IL6R PMC6057142__F1 Wnt/Beta-catenin signing pathway APC GSK3B LRP6 CTNNB1 PMC6854528__F2 Model of the AhR signaling pathway HEL-S-62p AHR AHRR CYP1A1 PMC9163667__F2 Activation of Wnt/Beta-Catenin Signaling Pathway as a Promising Therapeutic Candidate for Cerebral Ischemia/Reperfusion Injury APC GSK3B LRP5 LRP6 CTNNB1 PMC3690850__F7 Working model for rotavirus cell entry CDC42 ACTN4 ARHA EEA1 PMC4256868__F7 Isoprenoid metabolism in photosynthetic plant cells and its relationship to photosynthesis, glycolysis, respiration, and photorespiration IPP HEL-S-62p CS PMC5467707__F3 Pathway of Huntington’s disease enriched in target DEGs of DEmiRNAs of AD BAX REST SIN3A POC1A CASP3 TAF4 UCP1 HEL70 TBP BDNF APAF1 HTT PMC3923765__F2 BiNA: A Visual Analytics Tool for Biological Network Data BAX BAD FAS TNFRSF1A CASP12 TNFSF6 DFFB TNF MAP3K14 CSF2RB CASP6 NFKB1 NTRK1 NFKBIA CASP3 BCL2 ATM TNFSF10 APAF1 TRAF2 CASP10 PMC5467707__F4 Pathway of AD enriched in target DEGs of DEmiRNAs of AD LPL IDE CASP9 BAD CASP12 APOE GSK3B SNCA TNF RTN3 RTN4 CASP3 APP APAF1 FADD PMC5045435__F2 Notch signaling: its roles and therapeutic potential in hematological malignancies NOTCH2 NOTCH3 NOTCH1 PMC9523540__F3 Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction TFAM BAX ULK1 PRX MCU MTOR NRF1 SIRT1 PMC6675305__F4 Genes enriched in the VS (shaded) are contained in the canonical pathway for Ras/MAPK signaling CRK STAT1 BAD FYN MOS SRC BRK1 PMC6416842__F1 Simplified overview of one-carbon metabolism pathway MTRR HEL-S-61p MTR PMC5664647__F1 Working Figure of the Angiogenesis Pathway Genes NR1i1 TGFB1 CXCR1 EGFR FLT1 KDR IL8RB EGR2 TNF CXCL8 IRS1 IL1B PMC6881465__F1 Animal cell cytokinesis ECT2 PRC1 ARHA PLK1 PMC8624911__F1 Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO STAT3 STAT1 MRC1 TLR4 IRF3 IRF4 CXCL10 MYD88 PMC4530521__F1 Mini but Mighty - microRNAs in the Pathobiology of Periodontal Disease DGCR8 AGO2 DROSHA PMC4262777__F4 Tumor-derived exosomes are secreted via a constitutive/inducible pathway that can be activated by a p53-mediated response FAS RAB27B PMC4118469__F1 Molecular Mechanisms of Neurodegeneration in PD HTRA2 PINK1 LRRK2 HEL-S-162eP FBP1 SIRT2 PMC1351245__F1 Delayed Dark Adaptation in 11-cis-Retinol Dehydrogenase-deficient Mice RPE RDH5 RDH11 PMC9441916__F5 Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy HLA-DMB BRD4 EED LTA SELPLG SOAT2 CCR5 MPEG1 IL21R CTLA4 PTPN6 TBX21 RUNX3 BCLAF1 FCHO1 S1PR4 IFNG PTPN22 CD74 CBFB c-fgr ITK TRAF1 PMC2527618__F4 Graphic illustrating the roles of 8 genes implicated in the present study in lithium-sensitive signaling pathways NXN GSK3B TCF7L1 CTNNB1 PMC4826168__F2 DAB2IP in cancer EGR1 TRADD GSK3B DAB2IP MTOR SRC CTNNB1 PMC7746447__F2 TRPV2 regulation is involved in cellular responses relevant to cancer IGF1 TRPV2 INS PMC8415548__F5 Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy CISD2 TF SLC3A2 HEL60 ACSL3 ISCU GLS GPX4 FASN SLC38A1 SLC7A11 POR HMOX1 TXN FTH1 TFRC IPP FTL LPO HEL110 HEL-S-64p HEL-75 PMC9316955__F2 Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity IL10 HIF1A IL1B PMC6703955__F4 Proteostatic regulation of Ci/Gli proteinsAll Ci/Gli proteins, except mammalian Gli1, have an N-terminal repressor (R), a central zinc-figure (ZnF) and a C-terminal activator (A) domain SPOP SUFU PMC10820833__F2 Cellular senescence pathways affected by Tax ATR ATM SSB PMC6703955__F1 Outlines of Hh signaling(A) In Drosophila, Ptc keeps Smo inactive, partly by promoting its internalization and degradation KIF7 SUFU SMO GLI3 PMC6563445__F2 The proposed mechanisms of IRF5 activation SYK TLR4 TLR9 TLR8 NOD2 IRAK1 PTMS TLR7 TRAF6 IRAK4 CARD9 MYD88 PMC4858804__F7 Recycling and regulation of eIF2 by eIF2B LBH ELF2 EIF5 ELF5 PMC9563910__F1 Glucose 6-P Dehydrogenase—An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise RPE HEL-S-162eP PMC6859529__F5 Redox regulation of apoptosis under ER stress BAX ATF4 EIF2A TRAF2 PMC6703304__F3 Schematic picture of the type I interferon production and different nucleic acid sensors CGAS MAVS TLR9 IRF3 IFI16 IRF7 IRF8 TRAF6 IRAK4 MYD88 DDX41 TLR7 TREX1 PMC6859529__F3 UPR pathway under ER stress ATF4 EIF2A XBP1 PMC6703304__F2 Inducers and regulators of IFNA production by plasmacytoid dendritic cell APC PDC TLR9 TLR7 PMC10669635__F3 Partial epithelial to mesenchymal transition (p-EMT) and full EMT with associated biological markers CDH2 CTNNB1 PMC6703304__F1 Interferon receptors and signalling IFNG IFNE IFNK STAT1 IFNGR2 IFNGR1 STAT2 IFNAR2 IFNAR1 JAK1 TYK2 PMC10669635__F2 PI3K-Akt signalling pathway PTEN MDM2 PMC9314177__F6 Cebpb Regulates Skeletal Stem Cell Osteogenic Differentiation and Fracture Healing via the WNT/Beta-Catenin Pathway SP7 RUNX2 CEBPB TEF PMC4307112__F4 Differentially expressed genes in appetite control pathway between grass carp before and after food habit transition from transcriptome analysis GAL TRH DRD1 LEP GLS LEPR NPY PLTP AgRP PMC3628402__F6 Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence RPL5 RRM1 RRM2 MDM2 PMC4307112__F6 Differentially expressed genes in digestion and metabolism pathway between grass carp before and after food habit transition from transcriptome analysis CTRL FAS PLAT FOXO1 PIR CFTR INS PMC4858804__F1 Pathway for yeast cytoplasmic translation initiation ELF2 EIF5 ELF5 PMC4307112__F3 Differentially expressed genes in cell proliferation and differentiation pathway between grass carp before and after food habit transition from transcriptome analysis EGF FAS MOS INS PMC8864631__F7 Therapeutic siRNAs Targeting the JAK/STAT Signalling Pathway in Inflammatory Bowel Diseases IFNG JAK3 JAK1 PMC3317991__F6 RLIP76 Regulates PI3K/Akt Signaling and Chemo-Radiotherapy Resistance in Pancreatic Cancer BCL2 MTOR CDK4 PMC5594453__F3 Signaling pathways that are activated by TMEM16A in cancer EGF EGFR SRC PMC1395315__F1 Methionine-Homocysteine metabolism and related pathways HEL-S-182mP MTAP DHFR ADK CTH MTRR HEL-S-61p TYMS MTHFS PMC4482759__F3 From pathways to networks: connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry STXBP4 CPVL EPB41L3 PLK1 ACAD11 AP2A1 CACYBP RDX DNAJB1 DOCK7 APC AIP HGS ANAPC1 PRKCI ALG13 PNMA2 SNTB2 ENO1 SPTAN1 HEL-S-31 LONP1 P4HA2 NUDT21 SFN MAP2 TEAD4 LMO7 LATS1 HADHB LATS2 TEAD2 TEAD3 AMOT HELZ NF2 CPSF6 CIT NEK4 RPA1 CCDC6 TANC2 SHKBP1 WWC1 NUDC SKP1 SCRIB AJUBA MAP2K1 PMC4158839__F2 The development of the auditory sense organ SPRY2 FZD3 HEY2 SOX2 DVL2 FGF8 PMC5833124__F1 CX3CR1-CX3CL1 signaling pathway and migration process of immune cells via their interactions CXCR1 ADAM17 ADAM10 CR1 PMC6352210__F4 Internalization and cellular trafficking of FGFRs PAK1 FGFR4 FGFR1 FGFR3 SRC FGFR2 PMC2234347__F2 CNX/CRT cycle OS9 EDEM3 EDEM2 PMC4766407__F7 Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation PRMT1 IL1R1 JAK1 TRAF6 IL1B MYD88 PMC4963347__F2 Schematic representation of de novo and salvage pathways for NAD+ biosynthesis NRK HEL-S-90n NAMPT PMC1395315__F5 Elevated Homocysteine is associated with atherosclerosis LPL HMGCR CD36 MMP9 PMC6363996__F7 Model summarizing the inhibition of the cGAS-STING pathway by MDV VP23 TBK1 CGAS IRF7 PMC11731210__F10 Work model MYBL2 GC E2F7 PMC7605163__F6 TGFB Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation PHGDH PSAT1 ATF4 PSPH PMC9658487__F5 Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses PTEN MTOR CCND1 PMC3694890__F8 Novel Phosphopeptide Microarray Based Interactome Map in Breast Cancer Cells Reveals Phosphoprotein-GRB2 Cell Signaling Networks GRAP2 FLT3 STAT3 ZAP70 SYK SHC1 FRS2 SOS1 PILRA LAT EGFR PTPN11 IRS4 VAV1 PTPN6 IRS1 CSF3R PLCG1 FYN EPOR LAX1 LYN GRB2 SRC PMC8373148__F7 Towards a global investigation of transcriptomic signatures through co-expression networks and pathway knowledge for the identification of disease mechanisms CACNA1C CAMK4 ATF4 PMC9415972__F1 Harnessing Immune Evasion Strategy of Lymphatic Filariae: A Therapeutic Approach against Inflammatory and Infective Pathology TLR4 IL6 TNF IL1B MYD88 PMC8745448__F1 Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion LPA GAA ABHD6 CD36 FFAR1 PMC5713354__F2 Current possible strategies to bypass AVPR2 mutations responsible for X-linked NDI AQP2 AVPR2 EGFR ARHA SCT AVP PMC8621388__F1 Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands STAT3 BAX HK2 EGFR GRB2 MTOR FADD PMC10378552__F2 Exploring the Molecular Complexity of Medulloblastoma: Implications for Diagnosis and Treatment SUFU PTCH1 SHH SMO MTOR PMC6859529__F7 Redox regulation of IRE1A to control UPR XBP1 TRAF2 PMC11360082__F2 Catechol estrogens synthesis pathway in humans and the possible homologs identified in schistosome species CYP1A2 HSD17B3 HSD17B1 CYP1B1 CYP1A1 CYP3A4 PMC9162805__F3 IKKE in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology PDE3B TANK IRF3 IRF7 PMC8377231__F1 Mechanisms and Boundary Conditions of Drug Memory Reconsolidation CDK5 ATF4 EIF2A PMC12104430__F7 The OMD-induced regulation in hDPSCs upon LPS stimulation OMD IL1R1 NLRP3 TNF PMC9243319__F1 Revisiting chemoresistance in ovarian cancer: Mechanism, biomarkers, and precision medicine PARG PARP2 PARP1 PMC8729140__F8 Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming FAS ADIPOR1 ADIPOR2 SIRT1 PMC4484411__F1 Genetic/molecular alterations of meningiomas and the signaling pathways targeted RB1 STAT3 EGF PLCG1 CDK6 CDKN2C PTEN CDKN2B NF2 MTOR CDK4 PMC6005538__F6 Plasmatic membrane toll-like receptor expressions in human astrocytomas TIRAP PTEN MYD88 PMC7534289__F1 Two-Signal Models of Costimulatory and Inhibitory Pathways CD80 PMC5743771__F1 Challenges and Promise of Targeting the Liver X Receptors for Treatment of Inflammatory Disease SYK SUMO1 STAT1 ABCG1 SUMO2 NLRP3 PIAS1 IRF1 ABCA1 GPS2 PMC5743771__F2 Challenges and Promise of Targeting the Liver X Receptors for Treatment of Inflammatory Disease LPL TG ABCG1 FAS ABCG8 ABCG5 NPC1L1 LDLR PREB ABCA1 PMC4979589__F7 MUC4 is negatively regulated through the Wnt/Beta-catenin pathway via the Notch effector Hath1 in colorectal cancer APC GSK3B AXIN1 MUC4 HES1 CTNNB1 PMC9300463__F2 Expression analysis of candidate genes in S. nux-vomica (strychnine producer) and Strychnos sp. (diaboline producer) MAX SPNS2 SPNS1 PMC4621423__F2 Schematic diagram that gintonin-mediated in vitro cellular effects through LPA receptors in neurons and astrocytes is linked to in vivo pharmacological effects LPA ACHE ChAT HEL-S-11 PMC5660607__F7 Crosstalk of KDG molecular and network pathways NLRP3 SOS1 TLR4 NCKAP1L AIF1 DOK3 GRB2 SRA1 DOCK2 MYD88 PMC6157710__F1 Directing the use of DDR kinase inhibitors in cancer treatment CDC2 ERCC1 ARID1A TOPBP1 ATR ATRIP MTOR SETD2 CDK6 RAD17 WEE1 CDK2 ATM SMO CDK9 CCND1 CDK4 PMC3674242__F7 Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth LATS1 LATS2 PMC11612265__F3 Glycolytic reprogramming in macrophages orchestrates NLRP3 inflammasome activation in ALI/ARDS NLRP3 F2 PMC7461872__F3 Fve-type FIPs on the immune system, adapted from Hsu et al CD83 CD80 APC SRC PMC6429113__F8 Proposed model for role of MARK4 in regulating lipogenesis in pig placental trophoblast cells DKK1 MARK4 NR1C2 CTNNB1 PMC11612265__F1 Possible activation mechanism of NLRP3 inflammasome GSDMD MAVS NLRP3 TLR4 FADD PMC2887259__F5 Signaling cascades that regulate A VIP FYN IGF1 SLC18A2 GSK3B HEL-S-11 TRAF2 GAB2 IRS1 BDKRB2 PMC6653805__F6 Autophagy in Adipose Tissue Physiology and Pathophysiology LAMP2 NLRP3 ATG12 TLR4 ATG5 IL1B PMC7655160__F8 Graphical model displaying the mechanisms of ARHGEF11 in regulating cell cycle and EMT via activating Beta-catenin CTNNB1 PMC3339894__F2 Putative molecular mechanisms of Wnt signaling, lipid metabolism, and IL-6 effects on insulin signaling in nonobese PCOS adipose tissue CD44 STAT3 TG JUN APC LIPE IRS1 CTNNB1 PMC7759910__F2 SRC kinase during platelet activation HEL114 SYK PXN PLCG2 CSK TLN1 GRB2 PMC3218922__F6 Pathway generated by ingenuity pathway analysis with proteins identified as specific target antigens FH RPLP0 HNRNPD ANXA2 HEL-S-269 HEL-S-7 TUFM IL4 IMPDH2 HEL70 TNF SEMA4D HEL114 EZR PRDX3 FABP5 UGDH HEL-S-69p HEL-S-102 NPM1 ENO1 GRB2 RDX LMNA PMC7858073__F5 Signaling and molecular network mapping of genes differentially expressed in the ileal transcriptome of NCFM-colonized versus germfree mice (24 genes) using the Ingenuity Pathway Analysis software DBP LETM1 C3AR1 GSDMC MYC INSL3 RXFP2 DUOXA2 SHARPIN CCL23 PER3 IFNG CAPN13 TAC4 TPO ROMO1 TNLG1B BATF2 DUOX2 IL10RA TNF CYB5B TAMM41 HRAS RAF3 TMPPE BTN2A2 P2RY4 CCL8 PMC10837142__F5 Terpenoid biosynthesis pathway in T GGPS1 SQLE MVD FDFT1 PMC10837142__F7 Peroxisome biogenesis pathway in T PXMP2 MPV17 PEX19 PEX6 PEX5 PEX2 PXMP4 PEX16 PEX10 PEX12 PEX3 PEX13 PEX26 PEX14 PEX7 PTS PMC10837142__F6 Common symbiosis signalling pathway in T NUP133 NUP85 RAD1 PMC8861971__F7 An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer RB1 TSC1 CDK2 MDM2 CDK4 PMC7646582__F1 Diagram illustrating the diagnostic features of cutaneous melanoma and uveal melanoma CDKN2A PLCB4 SF3B1 EIF1AX KPG_011 BAP1 GNA11 KIT PMC11724797__F17 KEGG NF-kappa B signaling pathway—Homo sapiens (human) SYK EGF LTA TRADD TIRAP LAT CD14 BLNK TRAF6 MYD88 LTB CNTF NGF TRIM25 BCR COX2 TLR4 ATM LYN EDAR CYLD LBP PMC5837819__F2 CK1 in Developmental signaling: Hedgehog and Wnt APC LRP5 LRP6 SMO PMC12008652__F7 Application of biodegradable implants in pediatric orthopedics: shifting from absorbable polymers to biodegradable metals TRPM7 SMAD1 BMP2 PTH RUNX2 PMC9521521__F2 Deciphering the role of transforming growth factor-beta 1 as a diagnostic-prognostic-therapeutic candidate against hepatocellular carcinoma ARHA GRB2 MTOR TGFBR1 PMC12008652__F5 Cellular and molecular mechanisms revealing the potential effects of magnesium ions on bone repair TRPM7 MAGT1 TLR4 BMP2 CTSK LRP5 SP7 LRP6 NFATC1 TRAF6 CREB1 RAC1 PMC9120647__AF1 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo AXL GSK3B MTOR SRC CCND1 PMC10495745__F4 Activation of MAPK and TGF‐B‐SMAD signaling pathways in macrophages EGF MAP3K7IP1 EGFR SMAD2 SMAD4 ATF2 ARHA GRB2 SMURF2 PMC10953212__F4 Relationship between inflammation and NASH disease progression STAT3 NLRP3 JAK1 PMC6381062__F2 A working model of NPR1, NPR3, and NPR4 SUMO3 NPRC PMC10495745__F3 Activation of PI3K/Akt and Notch signaling pathways in macrophages RHEB PKD1 MAML1 TSC1 FOXO1 GSK3B PTEN RBPJ PMC10953212__F2 Glucose–insulin signaling pathway FOXO1 FASN GCKR GCK ENPP1 IRS1 PMC10495745__F2 Activation of the JAK‐STAT signaling pathway in macrophages IRF9 JAK1 TYK2 PMC5133678__F14 ‘Apoptotic execution phase’ gene enrichment in cisplatin-treated samples HMGB1 CLSPN SATB1 HMGB2 PMC7277093__F1 Role of CBS and other enzymes in the regulation of mammalian sulfur amino acid metabolism CTH HEL-S-61p PMC10495745__F1 Activation of the NF‐KB signaling pathway in macrophages TBK1 MAP3K7IP1 TRADD TLR4 IRAK1 IRF3 TRAF3 TRAF6 TRAF2 IRAK4 FADD MYD88 PMC10953212__F1 Lipid metabolism in NAFLD LPA APOC3 PNPLA3 MTTP CD36 TM6SF2 HSD17B13 MBOAT7 APOB PMC9510030__F1 Molecular inhibition of RAS signalling to target ageing and age-related health MDM2 GRB2 IRS1 PMC10495745__F5 Activation of GPCR signaling pathway in macrophages CDC42 STAT3 STAT1 APC GSK3B LRP5 LRP6 ARHA CCL5 CCL2 RAC1 PMC9456310__F7 SP and KLF Transcription Factors in Cancer Metabolism GPR17 SP1 UGDH PRC1 HEL-S-5 KLF9 PTGS2 PMC9456310__F6 SP and KLF Transcription Factors in Cancer Metabolism KLF4 OGT SP1 PFKP HEL-S-5 KLF8 FACL4 ERBB2 PMC8429580__F2 NLRP3 inflammasome activation and cell death BAX FAS GSDMD TRADD NLRP3 TLR4 TRAF5 DFNA5 TNF TRAF2 FADD MYD88 PMC4556964__F4 Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway LTB LPA PC PMC3311515__F1 Scheme for the intracellular renal RAS on the nuclear membrane ACE2 PMC11171484__F4 Systemic inhibition of TGFB signaling in the fibrotic lung by pirfenidone and localized inhibition of TGFB signaling in the fibrotic niche by bexotegrast (A,B) TIMP1 SMAD2 CTHRC1 SMAD4 COL3A1 PMC8997969__F2 Metabolic Reprogramming and Its Relationship to Survival in Hepatocellular Carcinoma ACLY LPA ADM PC ACACA HEL-S-87p CP PMC1963416__F1 Signaling mechanisms for the activation of HAT and HDAC HDAC1 NGF HDAC8 HDAC2 PMC8525887__F1 Schematic showing regulation of PAI-1 activation and its role in hepatocytes EPCAM PLG VTN MYC CCND1 PMC8087647__F3 autophagy in immune cells in the tumour microenvironment ATG101 CIC AGO2 ULK1 BCL2 ARG1 FOXP3 MYC ARG2 PMC8087647__F2 Impact of tumour autonomous autophagy on immunity CXCL9 NBR1 CXCL12 CXCL5 AIM2 IRF3 CCL5 CXCL10 PMC7247521__F6 Component-target-pathway-disease network TES PGR SOAT2 NR1C2 FADS2 POR RARA REN DRD2 MTTP CKMT2 NDN HEL-S-20 RARB tmp_locus_29 HEL-S-29 CNR2 RIC1 RXRB NR1i1 PTGER2 IL13 ME1 TNF APOA2 CKMT1B PIGR PMC8699356__F1 Interleukin (IL)-9 Supports the Tumor-Promoting Environment of Chronic Lymphocytic Leukemia STAT3 STAT1 BAD JAK3 GRB2 IRS1 PMC4488505__F5 Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin SYK JUN SOCS2 PTEN BMX MTOR MAP2 PTK2B MAPK8 CCNE1 RPS6KB1 NPM1 MAPK7 CDK2 BCL2 CDKN3 AKT1S1 MAP2K1 SRC RET EIF2AK2 LCK PMC8087647__F1 Machinery of canonical and non-canonical autophagy ATG101 ATG3 ATG12 ULK1 WIPI2 UVRAG AMBRA1 ATG14 PMC8429580__F1 NLRP3 inflammasome activation and cell death GSDMD NLRP3 TLR4 FADD MYD88 PMC3858477__F4 Transcriptomics of Glucocorticoid Receptor Signaling in Developing Zebrafish KCND3 EHD2 STAT3 SMPX SMAD2 CSDC2 FANCL CTSC HLX MAPK3 MAPK14 FANCD2 ISL1 BCR ASCL1 FOXN4 CRY2 FGFR1 ETV4 TPH2 TBX3 CPT2 RAB38 HES1 MLPH CRHBP SYT4 OLIG2 GCHFR TBR1 EPX SDHA GFAP MPZL3 OSBPL9 KCNIP3 AVP PDCD11 LMAN1 KLF2 FGF13 SGPL1 INA GAD1 FEV NEFL CS ATP6 GPX1 CCNG1 PDX1 F3 MSI2 JAG2 MFNG IRX2 RND1 CALB2 HEL-S-101 BACH2 HEL-S-302 ISOC1 IRX1 ARHA VHL IRX4 SPRY2 GCG MPZL2 MTDH FOXF1 NDRG4 CDC40 CDC37 PMC3952878__F4 FAK functions in cancer stem cells CD44 APC SOX2 GSK3B LRP5 SHH LRP6 MTOR MYC CTNNB1 PMC3313462__F4 Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes TH RRP1 HK2 PMC4964743__F3 Regulation of HER3 and downstream signaling NEDD4 PTEN GRB2 MTOR PMC12217143__F7 TgFLP12 function in Toxoplasma gondii lipid metabolism LPA ELOA ELOC PMC5865879__F1 Chemokine signaling pathway significantly enriched in differentially expressed genes CRK ARHH PREX1 SHE DOCK2 PMC8888875__F2 Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis IFNG COL1A1 KEAP1 SMAD2 APC MAF SMAD4 COL3A1 TNF IL1B CTNNB1 PMC4800799__F7 Model depicting the proposed effect of starvation on microRNA in cancer cells PLD2 PC PMC5556034__F6 Simplified scheme of the enzymes and transcription factors involved in de novo lipogenesis pathway FASN ACACA ELOVL6 PMC4403007__F3 Intricacies of cardiac damage in coxsackievirus B3 infection: Implications for therapy TLR3 IRF3 TLR7 PMC4725058__F2 Length of interaction alters the activation of specific transcription factors CDC42 ZAP70 JUN LAT STIM1 FOS UNK LCK PMC6689553__F4 Proposed metabolic pathway of the relevant eicosanoids GPX4 ALOX15 GPX1 PMC8873175__F1 Therapeutic Potential of Glutamine Pathway in Lung Cancer KLF2 GLS NUDT21 SLC38A3 DHODH PMC12015589__F7 Schematic diagram illustrating the beneficial effects of IL-7 during porcine early embryonic development BAX BCL2L1 SOX2 PMC6387269__F3 For using mTOR in PD treatment RHEB PTEN MTOR PMC8964978__F1 IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment STAT3 ADAM17 ADAM10 PMC4618674__F2 Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans CDC42 POR ERF TERF2 RHO CP HEL-S-15 PMC3435478__F2 Age-related alterations in receptors and signaling molecules of CD8 T cells CD27 CSK IL7R SOCS3 PMC8872633__F4 Protein cysteine palmitoylation in immunity and inflammation ZAP70 PLCG1 LAT ITK LCK PMC5182094__F2 Biosynthetic pathway connects cryptic ribosomally synthesized posttranslationally modified peptide genes with pyrroloquinoline alkaloids BAX HAL AMT PMC6559733__F1 Hypothesized therapeutic role of blocking IL6 pathway in Sarcoidosis IFNG IL6 MTOR PMC7412712__F2 Schematic description of TRAIL signaling cascade and interaction of lncRNA BCL2 POU3F3 APAF1 BIK FADD PMC3998825__F1 Alternatively Activated Macrophages Revisited: New Insights into the Regulation of Immunity, Inflammation and Metabolic Function following Parasite Infection KLF4 IL13RA1 IL33 IL21R IRF4 PMC3263596__F3 TGFB pathway in NetSlim CDC42 HGS TNC MMP12 ITCH MAFA SMAD2 ROCK1 APC TERT SKI FOS PMC6947814__F3 Regulatory roles of cellular IRES trans-acting factors (ITAFs) in EV-A71 translation FBP2 FBP1 PMC3772106__F1 How are STAT1 and cholesterol metabolism associated in antiviral responses? STAT1 TLR3 CH25H PMC10540347__F10 SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3B signaling pathway through P53 SQLE GSK3B PTEN PMC7756907__F1 One ring to bring them all and in the darkness bind them: The Trafficking of Heme without Deliverers. FLVCR2 HEL-S-162eP HP ABCG2 CD163 PMC8992556__F1 Intracrine androgen biosynthesis and drug resistance HSD17B4 HSD17B6 CYP17A1 HSD3B1 HSD17B2 AKR1C2 PMC7023715__F7 Activation of the PDGFRAlpha-Nrf2 anti-adipogenic signaling pathway impairs adipocyte differentiation in Nck1-deficient BM-MSCs HMOX1 NCK1 PDGFRA PMC7381711__F3 Summary of potential therapeutic effects of heparin in coronavirus disease 2019 (COVID-19) TF TFPI APC ACE2 PMC6429018__F8 Knockdown of PCAT-1 inhibited cell proliferation, metastasis, and promoted cell apoptosis in ECC cell lines GSK3B WNT1 CTNNB1 PMC3584589__F9 Two mechanisms by which miR-200a regulates the activity of Beta-catenin ZEB2 CTNNB1 PMC4872787__F6 IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer BMI1 STAT3 SOX2 PMC3338086__F1 Canonical and non canonical NF-kB pathways and related drugs inhibition CD40 RHD BCR RELA RELB PMC3068560__F4 Proteome of sickle cell disease: insights from exploratory proteomic profiling TCP1 PLG RAB8B PMC7836100__F2 Structural changes capture multiple regulatory events in yeast responding to osmotic shockA schematic of the yeast HOG-MAPK pathway and its links to glycolytic and glycerol biosynthesis pathways ENO2 HEL-S-68p F2 HEL-S-49 GPD1 PMC7255347__F1 Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19 TBK1 MAVS STAT2 IRF9 IFITM1 RNASEL IRF1 IRF3 IRF7 RAC1 MYD88 STAT1 TLR3 TLR4 TLR8 TLR7 JAK1 TYK2 PMC3877020__F4 UVA and UVB Irradiation Differentially Regulate microRNA Expression in Human Primary Keratinocytes HEL-S-273 RBMS1 RHOB CELSR2 DKFZp686P11128 MTRR MDH2 TYMS MMP9 POLD2 PMC5220330__F1 Interleukin-33 (IL-33)/ST2 signaling pathway IL33 IRAK1 TRAF6 IRAK4 MYD88 PMC2817430__F1 Phylogenomics of Sterol Synthesis: Insights into the Origin, Evolution, and Diversity of a Key Eukaryotic Feature IPP EBP DHCR24 DHCR7 TM7SF2 PMC2278091__F1 F igure 1.— STAR EGFR SMAD4 ARC RHO GRB2 SRC CTNNB1 VHL PMC7246871__F5 Closer examination of all drugs and pathways associated with the gene TNF PPARG PGR PLAUR PBR NF2 TNF PMC5454339__F3 Suppression of BCR signaling is detrimental to growth and sensitizes B-ALL to dex MAPK1 SYK PIK3R2 IL7R MTOR MEF2C MAPK14 TCF3 BTK CSK NRAS RRAS MAP2K2 PMC8781679__F2 An Updated Review on the Modulation of Carbon Partitioning and Allocation in Arbuscular Mycorrhizal Plants FAS PMC9667637__F3 Neutrophil extracellular traps in cancer progression, metastasis and therapy CXCR1 TLR4 TLR9 MPO PMC11822647__F8 Schematic image shows the role of neuronal CTSS in the process of aging and Alzheimer's disease (AD) STAT3 CX3CR1 CX3CL1 CTSS PMC5585150__F1 Pro- and antitumoral effects of tumor-immune cell heterotypic GJICs TNF IFNA1 PMC7140419__F4 Main signaling pathways playing role in autophagy activation ATG101 TSC2 TSC1 MTOR SIRT1 PMC9667637__F2 Neutrophil extracellular traps in cancer progression, metastasis and therapy TLR4 TLR9 CCDC25 PMC8040471__F7 Proposed model of PAK5-AIF signaling pathway in breast cancer proliferation BAX BCL2 PMC7330710__F1 Representation of some of the metabolic adaptation and reprogramming of cancer stem cells GOT2 FASN HEL-S-32 PMC5514546__F2 KEAP1-NRF2 Signaling and Autophagy in Protection against Oxidative and Reductive Proteotoxicity ATG10 HMGB1 ATG3 PMC2990540__F1 APC/C inhibition is regulated by signalling within the cytoplasm (a) and at the kinetochore (b) KNL1 MCC CDC20 UBE2S PMC9694162__F6 PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway in Resveratrol Alleviation of Zearalenone-Induced Oxidative Stress and Apoptosis in TM4 Cells BAX KEAP1 BCL2 PMC8889620__F2 Involvement of LDL and ox-LDL in Cancer Development and Its Therapeutical Potential CD226 STAT3 CDHR3 SOX2 LDLR MMP9 MTOR CCND1 PMC9114649__F3 Influence of Arginine Methylation in Immunity and Inflammation CXCL11 NFKBIA TRAF1 CXCL10 TNF CCL20 IL1B PMC9457753__F2 Lipopolysaccharide-Induced Model of Neuroinflammation: Mechanisms of Action, Research Application and Future Directions for Its Use TIRAP MAL TRPV1 CD14 IRF3 IRF7 TRAF3 TRAF6 MLSN2 MAP3K7IP1 TRPA1 NLRP3 COX2 TICAM1 TLR4 LBP PMC9114649__F2 Influence of Arginine Methylation in Immunity and Inflammation PRMT1 TH HLA-DRA MHC2TA APC NFKBIA PMC2897958__F4 Regulation of Lipid and Glucose Metabolism by Phosphatidylcholine Transfer Protein TG UCP1 CPT2 PMC5797008__F5 Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer NF1 SRC IGF2 PMC9114649__F4 Influence of Arginine Methylation in Immunity and Inflammation PRMT1 PRMT7 CARM1 IFIT1 IRF7 TAP1 CCL5 FOXP3 CXCL10 PMC4115244__F3 Pak Signaling in the Development and Progression of Cancer CDC42 BAD ARHA MYC PMC1553197__F8 Model of CISK-mediated inhibition of CXCR4 sorting and degradation CXCL12 PI3 CXCR4 PMC6208316__F2 Analysis of pathways responsible for the expression of TGFB target genes MYB FAS MAPK13 CD69 SMAD2 IRAK1 LYZ IRAK2 TRAF6 MYD88 NFKBIE IL18RAP LAT2 CD244 JUN ID2 KLF6 IL1RL1 VEGFA TNFSF14 SMURF1 PLK3 CASP3 GRB2 SMURF2 PMC9105177__F2 Roles of Ubiquitination in Pathogenesis of Influenza Virus Infection TBK1 MAVS TRIM25 IRF3 PMC7471650__F1 Signaling pathways underlying Sirt3-mediated regulation of autophagy SIRT3 MTOR PMC5539950__F1 Oxidative estrogen metabolism causes DNA adduct formation HEL-S-22 CYP1B1 CYP1A1 PMC4758903__F1 MicroRNA-based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer SPRED1 NF1 PTEN GRB2 SPRY1 PMC8351592__F2 Type I Interferon Induction in Cutaneous DNA Damage Syndromes CGAS IRF3 TREX1 PMC9367737__F2 Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies BMI1 CDK6 GSK3B WWOX PTEN MDM2 CDK4 PMC9448891__F6 Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells STAT2 SERPINA1 IRAK1 IRF3 IRF7 IL6 CXCL8 IRAK4 MYD88 STAT1 TLR3 TLR4 IL1B PMC2358943__F1 Metabolism of PtdIns(4,5)P2 by PLCG and PI3K TEC TSC2 TSC1 BCL10 PI3 PTEN MTOR PMC9222172__F3 Good and the Bad: Monocytes’ and Macrophages’ Diverse Functions in Inflammation STAT3 IL10 TIRAP TLR4 IRF3 MYD88 PMC9470863__F1 Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth CD80 MYD88 PMC8600858__F4 Transcriptome provides potential insights into how calcium affects the formation of stone cell in Pyrus ERF CAD PMC9569901__F1 Genome-Wide Identification, Characterization and Expression Analysis of Toll-like Receptors in Marbled Rockfish (Sebastiscus marmoratus) CD80 TIRAP TLR3 CTSK TLR9 CD14 IRF3 TRAF3 TNF MYD88 PMC6289770__F3 The lipoyl relay pathway of lipoyl-protein assembly.A LIPA LIPI LIPE LIPM PMC8120713__F4 Functional conservation in genes and pathways linking ageing and immunity SMAD1 DKFZp781O1323 ACVR1B BMPR1A EGFR SMOX ACVR1C IL6R PS1TP5BP1 PMC4055924__F6 CD28 signaling in myeloma cells CD80 PMC6478827__F6 Cell cycle regulation in GCs of small follicles CCND2 MTOR MYC PMC11607693__F1 Genome engineering Drosophila TGFB/BMP signaling TTLL12 CFP SMAD2 SPARC PMC10945329__F13 MSC-EV effect on bone regeneration IL10 NID1 NLRP3 WNT3A IL1RN CLEC11A BMP2 MSC HIF1A IL11 PTH TNF PMC4326213__F3 Immune-initiated, complement-mediated erythrocyte destruction in cold agglutinin disease (CAD) and cold agglutinin syndrome (CAS) HEL-S-62p C2 PMC10945329__F10 Exosomes generated from human adipose mesenchymal stem cells reduce hepatic fibrosis by suppressing the PI3K/Akt/mTOR signaling pathway and altering choline metabolism CHPT1 MTOR PMC7139953__F3 Mucins signaling in the benign and malignant pathologies of the colon MUC13 STAT3 ERBB4 LRP6 TRAF6 CTNNB1 ERBB3 CD44 FOXO3A MUC2 MUC1 ERBB2 MUC4 SRC PMC8787114__F2 Mechanoregulation of Vascular Endothelial Growth Factor Receptor 2 in Angiogenesis CDC42 FYN SHB ROCK2 ROCK1 RHO GRB2 SRC PMC7049507__F4 Analysis of miRNA‐mRNA regulatory network concerning Phospholipase D signaling pathway TH RAPGEF4 KITLG PMC7589708__F2 Wnt non-canonical signalling pathways ROR2 RHO DAAM1 PMC12149821__F1 Representation of phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin sequential signaling pathway in breast cancer BAD FOXO1 PTEN MDM2 CCND1 PMC3045367__F1 Exploring the Evolutionary Relationship of Insulin Receptor Substrate Family Using Computational Biology IRS4 IRS1 PMC6407099__F4 Role of Itch in Type I non-canonical Hh pathway ITCH PTCH1 SMO PMC6407099__F3 Role of Itch in canonical Hh pathway ITCH C2 SUFU PTCH1 NUMB SMO GLI3 PMC2634101__F1 Model summarizing some of the pathways described in this review leading to chemotaxis and cell motility CDC42 GC PTEN PMC5739549__F1 Mechanisms leading to transitory or sustained PD-1 expression in activated and exhausted T cells TIGIT APC PMC3977192__F8 LTP pathway components and interacting proteins: response in hippocampus CHP2 TH BAD EGR1 RAF1 DYRK1A ERBB4 SNCA MTOR PPP3R2 FOS CTNNB1 ARAF FYN BCL2 APP CHP1 RCAN1 CAMK2G PMC8085045__F7 Alantolactone inhibits cervical cancer progression by downregulating BMI1 CDH2 BMI1 RIPK3 STAT3 PMC3260807__F4 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health CIC DDR1 BRAF ATM PTEN MDM2 CTNNB1 PMC3260807__F2 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health RHEB BAD EGFR MEI1 MDM2 MTOR SHE SRC PMC3260807__F1 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health RHEB RPS6 TSC2 TSC1 PTEN MTOR EIF4E PMC6504273__F1 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway network for Kashin-Beck disease (KBD)-related genes PLA2G4C TNR CTSC ADCY9 F2R C9 LDLR ITGA6 HEL-S-108 F8 F9 PROC APAF1 RYR2 BAX MASP2 CFD SERPINA1 CFH PLG F13A1 F11 ITGB3 HEL-S-78p ITGA2B TNFSF14 MBL2 ITGB1 C2 FGA HLA-C PMC2490815__F4 IL-12, IL-23 and IL-27 are heterodimeric cytokines signals through Jak-Stat pathway and induce Th1/Th17 differentiation and T-bet expression in T cells IFNG STAT3 STAT4 IL23R TYK2 PMC9237599__F7 Exosomes-mediated tumor treatment: One body plays multiple roles BAX BAD SMAD2 PMC2490815__F3 Regulation of NFKB pathway by PPAR agonists in CNS diseases CD40 TLR4 TLR9 CD14 TRAF6 LBP MYD88 PMC3750075__F1 ACK1/TNK2, a non-receptor tyrosine kinase (NRTK), represents a paradigm of tyrosine kinase signaling that appears to be addictive in cancer cells EGF WWOX ERBB2 PMC5220089__F4 IPA-mapped CVD pathway for the 1890 compounds distributed in the top 10 herbs ZNF675 HCAR2 TAOK2 NMUR1 DAP PTGS2 SRC PMC3251006__F5 ECM-receptor interaction and focal adhesion pathway BAG1 HEL-S-28 PTEN SHE CD6 PMC8931742__F1 Schematic depicting the ER stress response signaling pathway after SCI ATF4 XBP1 PMC8146469__F1 Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2) VIP MRGPRX2 IL33 EPO PMC12111248__F9 Cdh23 regulating rod cell calcium ion transport (image created by Figdraw) GUCA1B GNAT1 CDH23 GC RHO PMC10929194__F1 Canonical pathways downstream of KRAS mutations JUN RALB RALA MTOR TBP KRAS OTUB2 PMC10929194__F3 Signaling pathways in the TME AXL TXNIP CXCL3 PMC11353192__F7 Lactate and LOX regulation of the HCAR1-RAS/PI3K signaling cascades TF HCAR1 LOX SOS1 GRB2 PMC5084369__F5 PHBHHx synthesis pathway with R-specific enoyl-CoA hydratase C6 C2 SCAI PMC9289230__F1 Neutrophils: New Critical Regulators of Glioma DDX5 HMGB1 FAS PMC4823071__F7 In silico pathway analysis in cervical carcinoma reveals potential new targets for treatment BARD1 FOXM1 ATM PMC3978517__F2 The replication checkpoint pathway activated following DNA damage TOPBP1 ATR ATRIP H2AX PMC3059437__F1 Shmt1 Heterozygosity Impairs Folate-Dependent Thymidylate Synthesis Capacity and Modifies Risk of Apcmin-Mediated Intestinal Cancer Risk DHFR SHMT1 TYMS PMC8361660__F6 Early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies RB1 CCND3 CDKN2A CCNE1 BRCA1 CDK2 CDK4 PMC8790521__F2 Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect GC CTLA4 FOXP3 PMC9353726__F8 Network of deregulated genes that were differentially expressed upon c-MYC inhibition after lomitapide treatment as determined by Ingenuity Pathway Analysis. Color code: green, downregulation; red, upregulation PARP10 BAD TP53INP1 MYC BIRC5 BTK BCL2L2 NFKB1 NFKBIA DDIT3 SP9 ARF5 NFKBIB PMC2913512__F2 G Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery GPR87 RHO MDM2 PMC9637672__F12 Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules NR1i1 CYP24A1 METTL1 CRTC2 PTH FGF23 PMC6433803__F2 Influence of non-oncogenic viruses on the components of non-canonical NFKB signaling CCL19 MAVS RELB TRAF3 TRAF2 PMC6667742__F7 A model demonstrating the multiple platelet activation pathways inhibited by the methylated metabolites of quercetin SYK PLCG2 LAT PMC6433803__F1 Non-canonical NFKB activation pathway RELB TRAF3 TRAF2 PMC8652378__F1 Oxalate synthesis pathway and molecular mechanisms leading to primary hyperoxaluria HOGA1 PMC3684282__F10 Schematic of myelin-mediated activation of the TGFB signaling pathway and downregulation of Smad2 by SLPI SLPI SMAD2 TGFBR3 TGFBR1 PMC7523359__F7 Roles and locations of CCND2 and CTNNB1 in Hippo signaling pathway and HPV infection pathway CCND2 GSK3B CTNNB1 PMC4001324__F1 Simplified overview of the receptor tyrosine kinase (RTK)-RAS and RAS-related RHEB signaling pathways RHEB CBL SOS1 NF1 SHOC2 PTEN MTOR PMC3502886__F1 PI3K/Akt/mTOR pathway regulates central carbon metabolism PTEN MTOR CIT PMC7532541__F8 AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway FAS CASP8 AFP FADD PMC9145061__F1 Functional Properties of Cancer Epithelium and Stroma-Derived Exosomes in Head and Neck Squamous Cell Carcinoma EGFR SMAD2 SMAD4 CMTM6 PTEN TSGA10 CDC37 PMC4915121__F1 Conserved longevity-regulatory components of insulin/IGF-1 signaling pathway in C PMC6073358__F9 Signaling pathways were regulated by HSAF CDK6 GSK3B CDK4 PMC2683723__F6 Insulin–EGF signal integration EGFR PIR SRC PMC3939313__F1 Quantitative Lipid Metabolomic Changes in Alcoholic Micropigs with Fatty Liver Disease TG SCD PEMT PC PMC3499189__F2 Synopsis of major pathways activating mTORC1 RHEB TSC2 TSC1 IGF1 LAT IGF1R IRS1 PMC4077447__F2 6-Thioguanine: A Drug With Unrealized Potential for Cancer Therapy APRT MTAP MTR PMC3499189__F3 Aberrations of PI3K-Akt-mTORC1 signaling pathway in prostate cancer RHEB TSC2 TSC1 IGF1 LAT PTEN IGF1R IRS1 PMC9125579__F5 Contribution of Mitochondria to Insulin Secretion by Various Secretagogues ME3 FH FASN MAL PC CS ME1 HEL-S-26 NNT NOX4 CIT PMC11900999__F3 This figure shows the role of NETs in AS and its related mechanisms VWF NR2A1 NLRP3 TFPI TLR9 HIST1H1E MPO PMC9125579__F4 Contribution of Mitochondria to Insulin Secretion by Various Secretagogues MAL TRPC1 MCU HEL-S-11 PMC11900999__F2 This figure shows a schematic diagram of the molecular mechanism of neutrophil suicidal NETosis GSDMD CDK6 HEL-S-162eP CDK4 MPO PMC4519337__F3 Transcriptome Profiling of Wild-Type and pga-Knockout Mutant Strains Reveal the Role of Exopolysaccharide in Aggregatibacter actinomycetemcomitans MPL NAGA NAGK PMC4589489__F3 Schematic of the ERBB(EGFR)/KRAS/BRAF/MAPK signaling axis, and its connection with the PI3 Kinase pathway PDPK1 EGFR PTEN MTOR PMC9583506__F2 TRIM family contribute to tumorigenesis, cancer development, and drug resistance SOCS1 TRIM13 TRIM14 TRIM32 TRADD SMAD2 TRIM2 SMAD4 PTEN MTOR TRIM21 CTNNB1 TRIM44 TRIM62 TRIM28 TRIM24 TRIM47 TRIM37 TRIM15 TRIM11 TRIM71 TRIM16 TRIM31 TRIM69 APC TRIM59 TNF CD44 TRIM46 TRIM25 TRIM67 TRIM52 TRIM8 ZNRF3 TRIM6 TRIM66 TRIM58 TRIM29 TRIML2 FADD TRIM23 PMC4034385__F1 Chromatin modifications as therapeutic targets in MLL-rearranged Leukemia DOT1L BRD4 ELL3 PMC4491517__F1 Schematic diagraming central role of pyruvate in glycolytic, citric acid cycle (CAC), and accessory pathways OGT TSC2 TSC1 CD36 PC MTOR PMC10921743__F10 AMPK involvement in central sensitization of chronic migraine TNC ARG1 UHRF1 PMC3912804__F1A Hedgehog signaling pathways in vertebrates-without hedgehog ligand SUFU PTCH1 SMO PMC8114223__F1 Implications of the germline variants of DNA damage response genes detected by cancer precision medicine for radiological risk communication and cancer therapy decisions BRIP1 RAD51D RAD50 RAD51 H2AX BRCA2 FANCM FANCC XRCC3 FANCE RAD51B FANCG FANCD2 FANCF RAD51C MRE11A BRCA1 ATM PALB2 PMC4496349__F6 MiR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer MAX NFKB1 ING5 MYC NRF1 HIC2 RBPJ PMC11125340__F7 Platelet-Derived Growth Factor Receptor Beta and JAK2/STAT3 Pathway CDC2 STAT3 GATA1 RUNX1 CCNE1 CDK2 RHO CCNB1 CCND1 PMC8395054__F3 CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy RB1 IGF1 CCND1 PMC4836462__F5 Morphogens involved in BBB development and integrity influence signaling of common pathways CDC42 EIF4EBP1 KIT PTEN RHO MDM2 MTOR CCND1 PMC7314312__F2 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism ACLY HEL107 CAD TXNIP NADK PFKFB2 PMC7314312__F1 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism RHEB TSC2 PTEN ATF4 MYC PMC8714965__F5 Compendium of Information on the Lysosome TSC2 TSC1 ULK1 ARL8B SLC38A9 PMC7314312__F4 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism MTHFD2 HEL107 CAD ATF4 PMC7314312__F5 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism ACLY NADK DHFR FASN HEL-S-26 NDP PMC8874499__F3 Deciphering the Interactions of SARS-CoV-2 Proteins with Human Ion Channels Using Machine-Learning-Based Methods GJD2 VDAC3 GNB3 RAF1 GNG13 KCNN3 TRPV1 MAPK3 REN TRPA1 KCNN1 COX2 IL18 APLN PLCB2 PRRT2 ITPR2 HEL-S-11 KCNN2 MAP2K1 PLCB3 TAS1R2 GJA1 TPCN1 PMC10376127__F2 New Insights on the Uptake and Trafficking of Coenzyme Q COQ10B COQ10A FDX2 COQ7 FDXR PDSS1 COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 COQ8B COQ8A IPP ALDH3A1 FDX1 PMC10376127__F1 Coenzyme Q functions ETFDH HEL-S-62p C2 NQO1 CHDH PRODH DHODH PMC11519791__F10 An illustration of the proposed role of cholinergic and calcium signaling pathways in ISIAF and WK treatment in neuronal and non-neuronal (cardiac) systems ACHE ChAT CHRM3 PMC4538308__F1 The mechanism by which DHA may interfere with the molecular signalling by activating glycolytic phenotype NR1C1 PTEN VHL PMC3912804__F2D Hedgehog signaling pathway in cancers -Type IIIb-Reverse Paracrine Ligand-dependent cancers PTCH1 SMO PMC3912804__F2C Hedgehog signaling pathway in cancers -Type III- Paracrine Ligand-dependent cancers PTCH1 SMO PMC4933505__F1 Emerging role of coagulation proteases in kidney disease TF TFPI F2 APC PC PMC3912804__F2B Hedgehog signaling pathway in cancers -Type II- Autocrine Ligand-dependent cancers PTCH1 SMO PMC3912804__F2A Hedgehog signaling pathway in cancers-Type I-Ligand-independent cancers PTCH1 SMO PMC5796261__F1 TREM2-DAP12 signaling TREM2 SYK CCR7 CTNNB1 PMC7047281__F3 Interaction network of differentially expressed miRNAs (DERs) and genes CDC2 NTS JUN JUND CTSW SHC1 EGFR JUNB RBL2 TNF CLEC3B KRAS IGF2 FOS IRS1 MAPK3 HRAS EREG INSR CCND2 GRB2 CDK4 PMC7862576__F7 Mdfi overexpression promoted C2C12 cell differentiation and positively modulated fast-to-slow-twitch muscle fibers transformation GNG2 ACOX1 PDK4 F5 CYCS CS MB HEL-S-87p TNNI1 ACADM MDFI PMC9701405__F6 Modular networks and genomic variation during progression from stable angina pectoris through ischemic cardiomyopathy to chronic heart failure CRP VEGFC TGFBI HGF ANGPT2 TNF SHE CCL2 POR REN CNR2 MMP2 MMP3 ERBB2 FLT1 PMC3962345__F4 Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5−/− Mice CDC42 EGR1 CDK5 MARCKS GRIN1 PMC8526972__F1 Inter-Kingdom Signaling of Stress Hormones: Sensing, Transport and Modulation of Bacterial Physiology TH PNMT DBH PMC3005418__F8 Rapid activation of the bivalent gene Sox21 requires displacement of multiple layers of gene-silencing machinery PRC1 SOX2 POLI HDAC2 PMC2801289__F1 UDP-galactose synthesis in L PMC5580928__F1 Post-translational Modifications (PTMs) that Modulate the Retinoic Acid-Inducible Gene I (RIG-I)-like receptor (RLR)–Mitochondrial Antiviral Signaling Protein (MAVS) Signaling Pathway TBK1 RNF122 MAVS RIOK3 RNF5 IRF3 MEX3C RNF125 USP15 USP3 TRIM25 USP4 C2 TRIM4 USP21 CYLD HDAC6 PMC3538326__F7 Proposed mechanisms of the reduced activation of G3139 in RIT-INPs CD40 CD80 MCL1 TLR9 BCL2 IL6 PMC7435027__F4 Illustration of the effects of acetaminophen on glutathione, antioxidant processes, and metabolic processes MTHFD1 ME2 ME1 HEL-S-26 PMC6397284__F4 Promoter hypomethylation of genes involved in myogenesis, structural dynamics of muscles and CDC42 signaling CDC42 FGD1 PMC7443979__F6 The molecular mechanism of the ascorbic acid anticancer effect TF EGLN1 SDHB TFR2 PMC4400383__F3 Insulin binding causes activation of the insulin receptor (IR), which phosphorylates different substrate adaptors such as the insulin receptor substrate (IRS) RHEB TSC2 PTEN EIF4E PMC3532605__F7 NFKB signalling pathway CD40 ZAP70 EGF LTA TGFA TIRAP RELB TGFBR3 NGF TLR3 PLCG2 RELA FLT1 MB TLR10 PMC11624796__F7 Natural lung-tropic TH9 cells: a sharp weapon for established lung metastases CXCL12 ITCH TRAF6 CXCR4 PMC3758882__F1 Normal complement activation cascade and its regulation C6 C7 HEL-S-62p C2 C9 VTN C4B_2 PMC6358298__F3 PTEN- and IPMK-mediated nuclear phosphoinositide signaling through SF-1 IPMK PTEN INS PMC4871119__F1 (Adapted from Alinari, Quinion, and Blum BTK BCR CD19 CXCR4 PMC5374451__F3 Molecular signaling involved in nephrogenesis SALL1 SIX1 GDNF SIX5 FRAS1 BMP7 SIX4 SIX2 EYA1 GATA3 CTNNB1 ROBO2 LMX1B WT1 RARA SEMA3A SLIT2 HOXD11 BMP4 FOXC1 WNT4 SPRY1 RET PMC4545518__F6 Simplified schematic of the canonical Notch signaling pathway GNE HES1 RBPJ PMC2884164__F5 Significant signaling pathway networks mined from pituitary adenoma comparative dataset MYCL KL PMC5300302__F7 The trans-sulphuration pathway coupled with glutathione synthesis CTH MAT1A PMC2915700__F6 Schematic representation of the line of events by which HA modulates the leukocyte-EC interaction CD44 HAS2 IL1B PMC9678227__F9 Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NFKB signaling pathway STAT3 SOCS3 IL1B PMC4638034__F3 Signaling pathways STAT3 MTHFD1 EGFR PC HEL-S-61p PMC3528620__F4 Chemokine Signaling Pathway from the KEGG database (ID: mmu04062) overlaid with log2 fold change values for genes differentially expressed between DBA/2 and C57BL/6 at day 14 PRKCE PRKCZ ARHA PMC6277787__F12 LPS signaling pathway in teleost macrophages NOD2 NOD1 PMC2884164__F9 ERK/MAPK signaling pathway that is involved with pituitary adenoma comparative-proteomic data BAD MOS ATE1 PMC3607163__F2 Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential ARHA DAAM1 CTNNB1 PMC3607163__F1 Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential DVL1 APC GSK3B LRP5 LRP6 TBP CCND1 CTNNB1 PMC6542591__F1 Adaptive and pro-apoptotic pathways of the UPR ATF4 EIF2A XBP1 PMC4554646__F2 Proposed biosynthetic pathway of the prodiginines and the related 4- m ethoxybipyrrole, YP1 PIGT PIGC SCO1 HBM ME1 PMC2634657__F2 Leptin Neuroprotection in the Central Nervous System: Mechanisms and Therapeutic Potentials EGR1 FOXO1 GSK3B EPO SOCS3 GRB2 PDK2 BDNF PMC8621753__F3 Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells SIRT3 AANAT ASMT SIRT1 PMC12067801__F4 ANO1 participates in various signaling pathways EGFR MTOR PMC8664842__F8 Working model of KDM6B inhibition in neuroblastoma KDM6B CDKN2A CTCF CDK6 EZH2 CCND1 CDK4 PMC6857641__F1 The tryptophan catabolism pathway TDO2 IDO1 KYNU KMO PMC5836032__F3 Outline of melatonin biosynthesis in the fish pineal gland SHD AANAT ME1 PMC5481368__F1 Scheme tentatively summarizing the involvement of ACBD7 and its related product NDN in the effects of leptin in the ARC ACBD7 NDN POMC MC4R NPY AgRP PMC8987581__F8 Anti-Inflammatory Effects of Ginsenoside Rb3 in LPS-Induced Macrophages Through Direct Inhibition of TLR4 Signaling Pathway COX2 TLR4 IL1B PMC4975561__F1 Roles of the PtdIns(3,4,5)P3/Akt pathway on insulin signaling in liver fat and muscle tissue with representative substrates indicated TSC2 PTEN INSIG1 PMC2811067__F2 Some of the stress response transcription factor pathways with homologs in N KEAP1 MAF AHR HIF1A PMC6385390__F4 Networks representing protein-protein interactions in differentially regulated proteins from the NOD1 (HS578T/NOD1) (a) and NOD2 (HS578T/NOD2) (b) experimental groups SDF2L1 SVIL RSL1D1 RAB1A RPL18 CADM1 RPL32 BRIX1 RPL36AL KCTD12 GC20 NIFK SHCBP1 ALDH1A3 FYCO1 STAT5B NOD2 MAPRE2 NOD1 RPL14 RPL7 AHNAK RTF1 ASCC1 RRM2 TPP1 RPL6 SEC23B RPL15 FTL RPL13A HNRNPUL2 ATXN1 PDLIM3 MYBBP1A RPL4 HLA-B AKAP12 HEL-75 PMC2269037__F3 PI3K/AKT signaling pathway activated by 3Alpha-diol RHEB TSC2 BAD PTEN EIF4E PMC6895449__F7 Illustration of the NEK2/Beta-catenin/Myc/KDM5B/H3K4me3 pathway ME3 KDM5B NEK2 CTNNB1 PMC6415318__F7 Schematic diagram of molecular mechanisms of Shuangyu Tiaozhi Granule (STG) attenuates hypercholesterolemia in rat fed HC diet ABCG8 ABCG5 HMGCR ACAT2 CYP7A1 LDLR PMC9204297__F3 NLRP3-Dependent Pyroptosis: A Candidate Therapeutic Target for Depression GSDMD NLRP3 CD36 TLR4 CS BDNF PMC9204297__F2 NLRP3-Dependent Pyroptosis: A Candidate Therapeutic Target for Depression NLRP1 GSDMD NLRP3 LDLR AIM2 PMC3059896__F2 Genetics and molecular pathology of Stargardt-like macular degeneration ADAM18 RAX2 CFP FANCC PMC4001025__F1 Vpr induces G2/M arrest through activation of the SLX4 complex CDC2 ATR CCNB1 PLK1 SLX4 EME1 PMC387762__F5 CREB pathway and possible positions of proteins whose genes contain CREB1 binding sites PACSIN2 ARHGAP8 GRB2 MIF CABIN1 PMC8678610__F5 Lactic Acid Transport Mediated by Aquaporin-9: Implications on the Pathophysiology of Preeclampsia AQP9 MPC1 MPC2 PMC9253674__F7 Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1B Pathway by Nrf2 Signaling Activation GSDMD NLRP3 KEAP1 GCLM GCLC MAF IL1B PMC9256000__F3 Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung HAVCR2 CXCL9 IFNG CXCL17 CCL22 CXCL13 EBP IL1RN CXCL16 TLR7 IL1A CD300LF PMC5912671__F2 Fanconi Anemia IFNG STAT1 ATR ATM PMC5912671__F1 Fanconi Anemia RAD51 BRCA1 BLM PMC4464398__F5 MAPK signaling pathway and neurotrophin signaling pathway maps MAX ECSIT ARHH JUN BAD FAS FRS2 BRAF CD14 ATF2 SHE FLNA NGF MOS RAE1 NLK GRB2 BDNF CDC25B PMC8666374__F1 Schematic diagram showing common components and pathways driving cirrhosis-associated immune dysfunction and novel coronavirus-related disease IFNG CD14 PMC8839250__F10 Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5 NRK NAPRT HEL-S-90n NAMPT PMC8091792__F1 Pyroptosis: a new paradigm of cell death for fighting against cancer NLRC4 BAX NLRP1 HMGB1 IL10 BAD NLRP3 IL13 GZMA IL18 AIM2 IL1B PMC4595979__F1 LOX pathway LOX tmp_locus_29 CS PMC3672007__F2 Ingenuity pathways analysis canonical pathway IGF1 signaling This figure shows the IGF1 signaling pathway, with significantly upregulated genes in red, downregulated genes in green, and genes that did not meet our criteria for significance in gray STAT3 JUN BAD GRB10 IGF1 OCEL1 IGF1R PMC11911380__F2 Inflammatory crosstalk and anti-inflammatory mechanisms in the angiotensin II-induced fibrosis pathway MAK TNF RAC1 PMC9480600__F5 Exosomes in Pharyngucutaneous Fistula After Total Laryngectomy SIRT3 NLRP3 KEAP1 PGAM5 GCLC MTOR AIFM1 PMC8891295__F1 Opposing transcriptional programs ensure cholesterol homeostasis in macrophages ABCG1 LDLR ABCA1 PMC4133945__F1 Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention DKK1 APC GSK3B CTNNB1 PMC8471303__F1 Age-Dependent Decrease in Hepatic Geranylgeranoic Acid Content in C3H/HeN Mice and Its Oral Supplementation Prevents Spontaneous Hepatoma IPP GGA1 PMC5731927__F6 Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway BAX BCL2 PMC5962057__F1 Monoclonal antibody targeting amyloid B (AB) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer’s disease C6 RPE C7 HEL-S-62p CFI C9 IL1B PMC5414755__F1 Signaling pathway regulating the initiation of autophagy and the formation of autophagosomes ATG101 ATG16L1 ATG12 AMBRA1 PMC12112713__F2 Notch signaling pathway PINK1 DLL4 JAG2 FURIN DLL3 PMC7975703__F7 Proposed Schematic for AKR1B10 activating TLR4/NFKB signaling pathway by promoting FFA synthesis in NPC TLR4 AKR1B10 MYD88 PMC1988867__F7 Ingenuity pathway analysis showing regulatory relationships among differentially expressed transcripts THBS1 CCK LEP HEL-S-133P GPX3 FOS SPP1 TAF1 MT2A PLAT IGFBP5 HSD3B1 NFKBIA SERPINB2 PMC10942021__F9 Crosstalk between mTOR and AMPK TSC2 ATP6V1D TSC1 TRADD FOXO3A CDK2 ARHA SKP2 INS PMC7239059__F5 SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing TMPRSS2 LOX CNTRL PMC6864306__F5 Relevant signaling pathways deregulated in glioblastoma: receptor tyrosine kinase/PI3K/PTEN/AKT/mTOR pathway is shown in blue, CDKN2A/CDK4/6/ retinoblastoma is shown in green and p53/MDM2/p14ARF signaling pathway is shown in red CDKN2A CDK6 LARGE PI3 EGFR PTEN CDKN2B MDM2 MTOR CDK4 PMC5742740__F1 Hippo signalling pathway in Drosophila and mammals LATS1 LATS2 YAP1 PMC4623399__F6 Summary of protein and metabolites data at t = 8 h C2 HEL-S-162eP PDC MDH2 PMC6251731__F6 Involvement of Akt in Mitomycin C and Its Analog Triggered Cytotoxicity in MCF-7 and K562 cancer cells CSA2 ND1 MCL1 HEL-S-28 PTEN MTOR EIF4E RHEB RHOB GDF15 CDC37 MDM2 GRB2 PMC7335506__F2 Therapeutic targets on the interleukin‐1 pathway IL1R2 IL1R1 TRAF6 IL1B MYD88 PMC8375987__F3 Three visualizations of part of the “PKC-gamma calcium signaling pathway in ataxia” at WikiPathways (wikipathways:WP4760) CACNA1A ATP2B2 TRPC3 PMC8202022__F5 Host-Parasite Interaction of Atlantic salmon (Salmo salar) and the Ectoparasite Neoparamoeba perurans in Amoebic Gill Disease NOS2 IL10 IFNGR1 JUNB IL6 FOS CTNNB1 TIGIT ITGAM COX2 TLR4 RELA MUC2 HEL-S-102 IL18 CASP3 IL10RB IL1B PMC4011807__F1 Pathophysiology of anthrax illustrated as a series of steps ANTXR1 LRP6 FURIN ANTXR2 PMC2839261__F1 Effector pathways stimulated by Beta-ARs EGFR MAPK7 MAPK10 ST18 MAPK6 PMC3443208__F4 Prenatal Exposure to TCDD Triggers Significant Modulation of microRNA Expression Profile in the Thymus That Affects Consequent Gene Expression KLHL20 EPHA2 KRT16 ADPGK MYLIP HSF2 POR BAMBI EPCAM PNP LATS2 CCNO WDR37 NAPG EPOR TNFAIP2 VASN CCND1 FGF16 NPRC BMPR2 AIP GALNT7 KLF15 MAPK7 AKTIP TWEAK NR3B3 PMC9495176__F6 Bioinformatics and Genomic Analyses of the Suitability of Eight Riboswitches for Antibacterial Drug Targets GLDC GCSH HEL-S-182mP PHGDH SHMT1 PMC11529186__F6 Peripheral nerve injury exacerbated progression of muscle HO, caused by the release of NRG3, which induced osteogenic differentiation of FAPs via the ErbB4/PI3K/Akt signaling pathway ERBB4 NRG3 RUNX2 PMC7661519__F4 Gene pathway analysis of the co-expression and co-localization of mRNAs in this study HMGB1 HEL-S-301 ABHD8 ARMC9 FRMD3 MVB12A CMPK2 RSAD2 MTOR CRIP2 SLC27A1 LOXL2 HEL-S-304 IFI44 NF1 MIB2 RNF144A SCA7 PMC9207209__F3 Yeast as a Model to Unravel New BRCA2 Functions in Cell Metabolism HEL60 COX1 ACO2 HAP1 ENO2 HEL-S-68p PGM2 CYC1 COX5A ENO1 HEL-S-26 PMC3713775__F2 MicroRNA and Signal Transduction Pathways in Tumor Radiation Response RAD52 ATR RAD50 RAD51 MRE11A BRCA1 H2AX BRCA2 ATM MDC1 PMC3713775__F1 MicroRNA and Signal Transduction Pathways in Tumor Radiation Response SUZ12 ATM EZH2 NRF PMC8508046__F3 Targeted Sequencing Revealed Distinct Mutational Profiles of Ocular and Extraocular Sebaceous Carcinomas MSH6 PIK3CA MSH2 PIK3R3 PIK3R2 BRAF PIK3R1 RPS27A KMT2A RB1 MDM4 FBXW7 SMARCC2 MAML1 RNF43 NF1 CREBBP ATM SKP1 EP300 MDM2 SMARCA4 PMC11823264__F4 JNK signaling pathway CDC42 TRADD MMP9 PMC6864436__F7 The schematic diagram of ICA activation of BMP2–induced osteoblast differentiation in C2C12 cells SMAD9 SMAD1 DKFZp781O1323 BMP2 RUNX2 PMC10879531__F6 Mechanism of action of Gal-3 in the A-ED through the TLR4/MyD88/NFKB pathway TLR4 TNF MYD88 PMC4818970__F3 Growth factor signaling pathway RHEB TSC2 TSC1 PTEN MDM2 MYC PMC8874510__F1 Structural View of miRNA Biogenesis and Function DGCR8 AGO2 DROSHA PMC7272522__F2 Antioxidant and detoxifying processes involved in genoprotective activities KEAP1 AHR HEL-S-44 PMC5870609__F5 Differential network of cancer pathway between BRCA tumor samples and controls EGF CXCL12 PIK3CA AKT3 PTEN RXRG EGLN3 FGFR2 TGFBR2 CDKN2A VEGFB COA3 CTBP2 ARNT2 HDAC2 CASP9 MSH2 PDGFA GNG2 CEBPA IKBKB EDNRA BMP2 EDNRB ERBB2 DAPK2 ZBTB16 LAMA3 GNG7 PMC4026869__F6 Gene network of 32 genes with pathway level expression change and mutation via GeneMANIA EHHADH THBS1 APPL1 RPL11 EGFR AKT3 BRAF HEL70 SKP2 COL17A1 HRAS TSC2 EFNB1 EZR MTBP MAP2K4 IKBKB RPS6KA3 MDM2 GRB2 PMC2831005__F10 Yeast cell cycle CDC20 FAR1 APC CLN3 PMC3940872__F7 Synthetic Alpha-Bromo-2′,3,4,4′-Tetramethoxychalcone (Alpha-Br-TMC) Inhibits the JAK/STAT Signaling Pathway OSM JUNB PMC6129988__F1 Current pathogenic model of psoriasis CXCL9 CXCL11 STAT3 IL19 CD83 STAT1 CXCL1 CCR6 PDC LCN2 CXCL10 CCL20 PMC3199787__F4 Graphical representation of the IL-6 signaling pathway reveals significant gene expression changes following sarin-induced seizure JUN A2M TRAF2 LBP UNK PMC3923671__F1 Impairment of T Cell Function in Parasitic Infections BAX FAS PMC8097256__F1 Human cell receptors: potential drug targets to combat COVID-19 TMPRSS2 DPP4 MSC BACE2 FURIN ACE2 PMC2626169__F1 A simplified view of the sex-determination pathway in XX animals (A) and XO animals (B) HTRA2 SDC1 SDC2 SDC3 PMC7319585__F2 Molecular steps of FEME carrier formation CDC42 SH3BP1 CDK5 OPHN1 PI3 GSK3B BIN1 PMC4314372__F1 Biology of Castrate Resistant Prostate Cancer CYP17A1 SOX9 SMAD2 SMAD4 EZH2 PTEN ERG MTOR SRC MYC SOX4 CTNNB1 PMC4785274__F1 H2S biosynthesis, functions, and metabolism PMC6085621__F7 Gold nanoparticles and Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 MYC CCND1 CTNNB1 PMC2837947__F2 Disruption of metabolic pathways involved in fat pad mass trait in mouse models of the candidate genes LPL TGFBR2 GAS7 TG C3AR1 LACTB ZFP90 GPX3 ME1 PMC9170767__F1 FunHoP: Enhanced Visualization and Analysis of Functionally Homologous Proteins in Complex Metabolic Networks CARNMT1 LPCAT3 LYPLA1 PLA2G5 PLA2G4C PLA2G2D PLA2G2F FTCD PLA2G12B PISD MAOA PLA2G10 ALDH2 ALDH1A3 ALDH3A1 HAL CNDP2 PLA2G4E PLA2G4F DDC CNDP1 GPCPD1 UROC1 HDC PNPLA6 PEMT CEPT1 PLA2G4B PMC7471649__F6 Protein-protein interaction analysis by STRING TGFB1 PMC9170767__F3 FunHoP: Enhanced Visualization and Analysis of Functionally Homologous Proteins in Complex Metabolic Networks MGA PMC11045904__F3 Intricate relationship between the gut and brain axes in PD is delineated by the schematic signaling pathway, with a focus on the inflammatory cascade triggered by dysbiosis at the gut lumen and BBB TH TLR4 PMC2846056__F3 Making the blastocyst: lessons from the mouse LATS1 CDX2 LATS2 TEAD4 PMC11045904__F2 Inflammatory signaling pathway involved in AD is depicted in the figure NLRP3 APP TNF IL1B PMC9277163__F11 Protective Effects of Cinnamaldehyde on the Oxidative Stress, Inflammatory Response, and Apoptosis in the Hepatocytes of Salmonella Gallinarum-Challenged Young Chicks TSC2 TSC1 GSK3B MTOR PMC4947689__F1 Hcy metabolism HEL-S-61p PMC6678355__F5 Unigenes involved in the Wnt signaling pathway: Red and green represent upregulated and downregulated genes, respectively POR BAMBI SOST SIAH1 ROCK2 APC CER1 SMAD4 SKP1 ARHA NLK DAAM1 PMC3051184__F9 Proposed model explaining upregulation of CREB expression by RA in NHTBE cells SP1 SP2 PMC6414239__F1 Metabolic perturbations in classic galactosemia beyond the Leloir pathway: insights from an untargeted metabolomic study PMC8027222__F6 Mating type specific transcriptomic response to sex inducing pheromone in the pennate diatom Seminavis robusta TOMT MYB RAD51 CDC20 MRE11A GC OCEL1 ATM PMC5222372__F1 Overproduction of Alpha-Lipoic Acid by Gene Manipulated Escherichia coli LIPA APOD PMC4659438__F4 Molecular pathogenesis and potential treatments for thrombotic microangiopathy in the glomerular endothelium TF VWF HEL-S-62p APC VCAM1 TNF PMC6054450__F3 Merkel cell carcinoma ARID1A KMT2C BCOR MCC MSH2 BRCA2 ASXL1 MTOR NOTCH2 KMT2A RB1 BRCA1 ARID1B MLL2 ATM NOTCH1 SMARCA4 PMC7758635__F7 Hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development BOC PTCH1 SMO PMC7746424__F2 Immunomodulation and cell apoptosis induced by the dopamine pathway STAT3 HEL-S-101 DRD1 DRD2 GSK3B PMC3109102__F1 Basic intracellular molecular pathways regulating MN survival during development CASP9 CASP8 CASP3 PTEN MDM2 MTOR APAF1 PMC6306858__F1 Primer of the inflammatory cascade TH CSA2 FAS IL16 IL1B MYD88 PMC5595802__F1 Melanoma (Skin) tumorigenesis pathway, collected from KEGG BAD BRAF PTEN CCND1 CDK4 PMC5524810__F1 Angiotensin II signaling pathway underlying vascular aging MMP2 MMP9 PMC8962104__F2 Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications MYOC TMCO1 ROCK1 ATF4 BDNF OPTN XBP1 AQP1 PMC4349622__F3 Schematic diagram showing the multi-regulation loops of LRRC4/NGL-2, miRNAs, TFs and target genes in glioma SP1 LRRC4 BRD7 E2F6 ARHA MYC PMC4349622__F2 Schematic diagram showing the signaling regulation network of LRRC4/NGL-2 in glioma STAT3 CDK2 CXCR4 CCND1 CDK4 PMC5610024__F4 The dual role and therapeutic potential of high-mobility group box 1 in cancer HMGB1 TLR4 PMC1304643__F2 Probability flux distributions for human red blood cell HEL107 HEL-S-162eP KIN ADA PMC7815415__F5 PPAR signaling pathway of potential targets of allicin LPL UBC HEL-S-28 PLTP PMC11611192__F8 The signaling pathway by which high glucose participates in the GEnCs injury via the RXRA/circ8411/miR-23a-5p/ABCA1 pathway GSDMD RXRA ABCA1 PMC3960371__F4 Autophagy Paradox and Ceramide BAX CERS1 BNIP3 MTOR PMC5658785__F4 Roles of microglia/macrophages in tumor progression of brain cancer and metastatic disease MMP2 IL1B S100B PMC8159759__F1 Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases NLRP3 CD36 TLR4 NOD2 NOD1 SRA1 PMC5343846__F2 Effects of the loss of cell division cycle 73 (CDC73)/parafibromin on epigenetic regulatory mechanisms in PCas CDC73 EZH2 RNF20 CTNNB1 PMC5343846__F1 Wnt/Beta-catenin pathway is potentially deregulated in PCas WT1 HIC1 CDC73 DKK1 APC LRP6 AXIN2 CTNNB1 PMC5975105__F1 Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins NPC2 ABCG1 NPC1 HMGCR LDLR OSBPL9 ABCA1 OSBPL6 PMC8350729__F2 Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications STAT3 BAX JUN BCL2 SMO HIF1A MTOR CCND1 PARP1 PMC9364366__F1 Key role of sphingolipid metabolism in cancer: New therapeutic targets, diagnostic and prognostic values, and anti-tumor immunotherapy resistance CERK SMS tmp_locus_29 PMC6428898__F3 Mec1/Rad53 pathway senses ongoing DNA replication to inhibit mitotic entry DBF4 MRC1 SOST PPIE PNMT PPL RET PMC8669377__F2 Targeting the “sweet spot” in septic shock – A perspective on the endothelial glycocalyx regulating proteins Heparanase-1 and -2 TFPI CD14 BDNF PMC7181071__F1 Main pathway for autophagy modulation ATG101 ATG10 ATG3 ATG12 ULK1 UVRAG TFEB ATG5 PMC7935919__F3 Schematic illustration showing altered coagulation pathway proteins in polycystic ovary syndrome (PCOS) TF VWF TFPI PLG FDPS PMC9146244__F2 Neurotrophin Signaling Impairment by Viral Infections in the Central Nervous System NGF BDNF CTNNB1 PMC7903350__F6 Compound-target network of EIF PRLR EGF PIK3CA GNRH1 SOS1 TACR2 EGFR GSK3B PIK3R1 GHRH PTEN IGF1R PPP2CA MTOR INS GNAS PELP1 BCL2L1 INSR ATM KDR MDM2 SRC GNAI1 TAC3 CYP17A1 PTPN1 PTK2B TACR3 VEGFA NCOA1 CYP1A1 IRS1 HEL114 GNG2 KISS1 CDKN1A FOXO3A CREBBP EP300 MAP2K1 GRB2 PMC7903350__F5 Pathways related to hypothalamic-pituitary-gonads axis and targets of EIF CDC42 BMP15 BMP6 HBEGF EGR1 RAF1 INSR MAK LDLR MMP2 FSHR PMC7412063__F4 Interactions between network molecules and DNA damage checkpoint pathways ACAN PGLYRP1 OAF ATM PLA2G2E PLK1 CP PMC5940270__F2 CGAS–cGAMP–STING pathway detects cytoplasmic DNA after DNA damage and activate type I IFNs and other cytokines TBK1 CGAS IRF3 TREX1 PMC6096065__F7 Protein-protein interaction network of predicted target genes of hsa-miR-203 CUTA SPARC CP ADA PMC6096065__F6 Protein-protein interaction network of predicted target genes of hsa-miR-1 ANKRD29 MCAT ABI2 SHANK2 LRAT ZNF43 ZNF14 PCDHB3 PUM2 CTNNA2 MON2 RIT2 RARB AMOT NOTO STEAP2 INMT KRAS PTPRG LRCH2 SMYD4 RYBP DKFZp686P11128 UST MMD IMPACT PMC4963809__F2 Schematic illustration of the canonical Wnt signal transduction cascade APC GSK3B LRP5 LRP6 CTNNB1 PMC8227153__F4 Rintatolimod Induces Antiviral Activities in Human Pancreatic Cancer Cells: Opening for an Anti-COVID-19 Opportunity in Cancer Patients? TLR3 IFNAR2 TICAM1 IFIT1 IFNAR1 RNASEL IRF1 IFIT2 IRF7 OAS3 ISG15 MYD88 PMC3236209__F6 Transcriptome Analysis of H2O2-Treated Wheat Seedlings Reveals a H2O2-Responsive Fatty Acid Desaturase Gene Participating in Powdery Mildew Resistance MYB ERF LOX HEL-S-5 PMC5794417__F8 Schematic diagram on regulation of PCSK9 on apoB via modulating the autophagy pathway affecting atherogenesis PCSK9 ULK1 ATG14 APOB MTOR ATG5 PMC7255975__F2 Hypothetical mechanism by SARS-CoV-2 in establishing an inflammatory feedback loop between IL-6 and angiotensin II ADAM17 ACE2 PMC8888908__F1 Autophagy in the Neuronal Ceroid Lipofuscinoses (Batten Disease) ATG10 ATG3 ATG12 ULK1 UVRAG ATG14 ATG5 LCK PMC5731853__F7 Let-7g suppresses both canonical and non-canonical NFKB pathways in macrophages leading to anti-atherosclerosis BAX IL16 RELA RELB SREBF2 ABCA1 PMC3465517__F5 Network analysis of proteins found to be significantly altered in abundance in the CSF proteome by ANOVA (p value <0.05) following analysis of individual subject samples TF SERPINF2 CSF1 HSPG2 SPARCL1 THY1 C1R IGFBP6 ORM2 SCG5 CLU BCAN ADAM22 PROS1 A2M APP FBLN2 HEL-S-44 HEL-S-2 SERPING1 CFD SERPINA3 ORM1 SERPINA1 CFH HRG RBP4 CNTN1 IGSF8 IGF2 SPP1 CD44 GM2A SCG2 HEL-S-130P CHGB HP APLP1 CP PMC9367204__F1 Of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesis TMPRSS2 ORAI1 STIM1 PI3 ACE2 PIKFYVE PMC5890336__F1 Canonical PI3K/AKT/mTOR signaling pathway ERBB3 RHEB TSC2 TSC1 ERBB2 PTEN DEPTOR IRS1 EIF4E PMC3077214__F1 Signaling pathway components used to test gene–compound interactions EGF JUN SPR SMO PTEN PMC5582926__F9 Schematic description of EET-mediated perturbations in the Wnt1-NOV-PGC-1Alpha-HO-1 pathway in cardiac and adipose tissue of db/db mice WNT1 IL6 IL1B CTNNB1 PMC7302136__F9 LncRNA LINC00314/miR-129-5p/GRM5 in osteogenic differentiation of ADSCs CTNNB1 PMC8210162__F11 Novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells MDM4 SRSF10 TRIM28 MDM2 PMC10758056__F8 NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway CDC2 TOPBP1 ATR ATRIP PMC10742465__F7 The proposed cardioprotective mechanism of hydrogen after CIH exposure FBXL5 KEAP1 FES PMC2881280__F1 Schematic representation of the proposed enzymatic steps in the FAC -elicited JA biosynthesis pathway regulated by SIPK, WIPK and NPR1 LOX GLA PMC4586799__F4A The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis SUFU GSK3B DHH IHH SMO ENO1 PMC3975884__F1 EGFR associated signaling pathways in lung cancer RHEB EGF EGFR MTOR SRC KRAS PMC9603893__F3 Integrin Alpha v Beta 6 (AvB6) and Its Implications in Cancer Treatment VTN RAC1 PMC84608__F12 The central role of the E2F transcription factors in cell proliferation and apoptosis CDC6 PIGS PMC5998975__F8 Proposed crosstalk pathway between A2AR signaling and Semas SEMA4D SEMA3A ERBB2 ARHA PMC11123779__F5 Protein–protein gene network in RA-infected ducks PLB1 PCBD1 NCF2 OTC SDC4 IRAK2 CCL2 MME USP18 MMP2 NFKBIZ LAG3 TNFRSF11A NOS2 PTGER3 MMP10 IRF9 KIF17 IRF7 RSAD2 TNF ATF3 ZC3H12A CCL19 CCL4 HBE1 CD36 PGR CREM ENTPD4 GGT7 NTNG2 PTPN13 SCRG1 IFNGR2 APP CEBPB CCL17 FAM13A IL10 NGL1 BST1 CXCL6 BCL11A NFKBIA ACKR4 CISH BIRC2 IL13RA2 TNFRSF11B PMC7204509__F4 EP remodels purine and arginine metabolism, glutathione homeostasis, and the Krebs cycle in BMDMs MAL CIT PMC6676405__F2 Putative Cripto-1 targets the MAPK, FA and ErbB signalling pathways CRK PXN FGFR1 BCL2 SRC PMC9241025__F3 Gene Regulatory Circuits in Innate and Adaptive Immune Cells TH STAT3 RORC IL33 STAT4 RBPJ GATA3 IKZF3 PMC10342783__F9 Phenylalanine metabolism (a) and neuroactive ligand-receptor interaction (b) KEGG pathway PMCH PRLR NTS TRH CCK LEP OXTR LHB SCTR TSHR HEL-S-62p TACR2 CRH GHRH NMU GHRL FSHR LTB4R LPA NPFF UTS2 APLN NPY PTGFR GHR HCRT OXT GRPR VIP MLN TAC3 GAL LEPR TACR3 TRHR CALCR SST MLNR GHSR UTS2R GNRHR PTH SCT GIPR AVP PMC6566886__F4 Adiponectin-induced signaling pathway STAT3 BAX TSC2 APPL1 ADIPOR1 ADIPOR2 PTEN MTOR IRS1 PMC6566886__F3 Leptin-induced signaling pathway STAT3 COX2 GSK3B AIP GRB2 EXOG CCND1 IRS1 PMC9180116__F4 O-GlcNAcylation: The Underestimated Emerging Regulators of Skeletal Muscle Physiology OGA RPE OGT FH GNE PDC NAGK CS GALP IRS1 PMC10603888__F10 Signal path analysis: (A) thyroid hormone synthesis (Calcium ions within the cell are transported outside the cell via the transmembrane, as indicated by the red boxes TH TG TTF2 TSHR HEL111 TPO DUOX2 DAO HEL-75 PMC7707960__F2 Putative schematic of the Rac1 signaling pathways involved in different neurodevelopmental disorders SHANK3 NRG1 ERBB4 AUTS2 BDNF ELMO2 RAC1 HTT PMC7707960__F1 Regulation and interaction of Rac1-related signaling pathways at the postsynaptic terminal SHANK3 CDKL5 AUTS2 BDNF ELMO2 RAC1 PMC7218999__F7 Protein-protein interaction analysis based on STRING with an interaction confidence score (0.400) HEL107 SUMO1 SUCLG1 RPS3 COX2 GLO1 PDK2 PURB HEL-S-30 MCCC1 AKR1B1 NCL PMC8440935__F4 Spermine-Related DNA Hypermethylation and Elevated Expression of Genes for Collagen Formation are Susceptible Factors for Chemotherapy-Induced Hand-Foot Syndrome in Chinese Colorectal Cancer Patients TPH1 MTAP HLA-F HEL-S-62p HOXA4 MTR DDC PMC4945713__F3 Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease TH NGF LIF ChAT PMC8263651__F8 Mortalin maintains breast cancer stem cells stemness via activation of Wnt/GSK3B/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC4821805__F1 Evolution of haem biosynthetic and degradative pathways HMBS CPOX FECH UROD UROS PMC7883771__F3 RA signaling and OFCs CYP26B1 ALDH1A3 TBX1 SHH LRP6 RERE CYP26A1 CP PMC5142116__F1 Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy DBP PNP HEL-S-302 HLF TEF PMC9582522__F3 Brain-gut-muscle axis in human health and energy homeostasis VEGFB TGFA IFNAR1 SOCS2 AHR PMC9582522__F2 Brain-gut-muscle axis in human health and energy homeostasis FGF8A IRAK1 IRAK2 NPY AgRP PMC5503659__F1 Roles of long noncoding RNAs in colorectal cancer metastasis BAX PMC4885862__F4 Survival strategies used by E ADAM17 NEDD4 TLR4 COPA FURIN CAP1 PMC4885862__F3 Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy DAZAP2 VPS29 FZD5 KLHL12 KDM6B IRF2BP2 PORCN ARID1B LRP6 ARHA RAC1 CTNNB1 PMC5728441__F1 Found in translation: how preclinical research is guiding the clinical development of the BCL-2-selective inhibitor venetoclax BAX BAD HRK BIK PMC5503659__F3 Roles of long noncoding RNAs in colorectal cancer metastasis CD44 TCF7L2 BCL2 PTEN HNRNPK MYC RAB22A CTNNB1 PMC3684061__F4 Genetic Risk Factors for Pancreatic Disorders CASR SPINK1 CTRC CFTR PRSS1 CLDN2 PMC9279633__F1 Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles GABARAP ULK1 SNAP29 UVRAG ATG14 MTOR STX17 PICALM ATG3 ATG12 TFEB NRBF2 APP ATG5 ULK2 PMC3109860__F4 CHK1 Inhibitors in Combination Chemotherapy BAX ATR ATM SRC PARP1 PMC8007787__F1 Reverse transsulfuration pathway and inputs from associated pathways VIT HEL-S-61p PMC4383754__F1 Cholesterol synthesis and metabolism in the brain NPC1 HMGCR DHCR24 DHCR7 PMC8268312__F3 Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators STAT1 MAVS STAT2 IRF3 JAK1 TYK2 PMC9173833__F6 SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1 IL13 IRF1 IL6 TNF PMC8268312__F1 Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators TMPRSS2 MAVS TLR8 IRF3 TLR7 ACE2 MYD88 PMC2939656__F4 Complement/Coagulation pathway activation C6 CD59 CPB2 KLKB1 C3AR1 F5 F7 CR2 C4A CR1 PLAT F2R F2 F10 F3 PROS1 C9 THBD A2M F8 F9 C4B_2 PROC VWF C7 PLAUR PLG F11 C2 PMC9372463__F2 Influence of metabolic syndrome on age-related hearing loss from the perspective of mitochondrial dysfunction SIRT3 IGF1 SIRT1 PMC3563405__F1 represents the melanin synthesis in human, plants, fungi and bacteria starting from tyrosine whereas; (B & C) shows melanogenesis from secondary metabolites in fungi and bacteria respectively SCD DCT TYRP1 PMC6329659__F4 Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair H2AX GSK3B ATM DISC1 PMC7273800__F3 Gene–gene networks generated by pathway analysis from the 17-gene set PACSIN2 TMOD1 CYP2A6 STAB2 ACKR2 ERAF CLEC11A TCF2 IAPP SHANK3 BAZ1A ABCG1 LCOR INPP4B CLEC4A TNFSF11 FOXA2 TNFRSF11B ABCB1 UNC119 PMC11856986__F6 Associations between stroke and vascular dementia combing Mendelian randomization with network pharmacology STAT3 BAX PIK3CA BAD HGF TGFA AXL EGFR BRAF PTEN GRB2 SHE PMC6039250__F5 NRF2 and the hallmarks of cancer MTHFD2 HEL107 TXN UCP3 GLS GCLM GCLC FASN SHMT1 ME1 HEL-S-51e PSPH PMC7923894__F2 Investigating the Convergent Mechanisms between Major Depressive Disorder and Parkinson's Disease AQP4 TLR4 GC PMC8897867__F1 Activation of cryptic xylose metabolism by a transcriptional activator Znf1 boosts up xylitol production in the engineered Saccharomyces cerevisiae lacking xylose suppressor BUD21 gene MAL FBP1 ZNF14 ENO1 PMC7920504__F4 Candidate genes for osimertinib resistance presented within cancer-related signal pathway EGF JUN BAD TGFA NRG3 MTOR SHE MYC NRG4 NRG2 CRK NRG1 HBEGF BTC GRB2 PMC6039250__F2 NRF2 and the hallmarks of cancer RBX1 GSK3A KEAP1 GSK3B SKP1 PMC7888496__F4 Proposed model of the role of the JAK-STAT signaling pathway in the development of FLHS in chickens STAT3 CNTF PTPN1 SOCS3 IL6 PMC8584061__F4 Emerging Importance of Tyrosine Kinase Inhibitors against Cancer: Quo Vadis to Cure? FLT3 PIK3CA SOS1 EGFR PIK3R1 BRAF PTEN IGF1R FGFR2 ALK NF1 ERRFI1 FGFR4 FGFR1 RIT1 MAPK1 ROS1 ERBB4 NTRK2 PTPN11 KIT KRAS RAC1 ARAF ERBB3 HRAS CBL PDGFRA NTRK1 ERBB2 FGFR3 MAP2K1 RET PMC3270095__F4 Regulatory network for PACAP-responsive genes KLF4 BTG2 HEL-S-102 ATF4 FOS PMC5890889__F4 Proposed ferritin-mediated feed-forward inflammatory loop HMOX1 TLR9 CD163 PMC4910120__F4 Therapeutics in development target the IFN pathway in SLE DNASE1 PDC TLR9 TLR7 JAK1 TYK2 MYD88 PMC4910120__F3 Overlapping type I, II and III IFN signaling pathways IFNG IFNK STAT1 STAT2 JAK1 TYK2 PMC9686445__F9 Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations CCL26 CCR3 PMC9686445__F6 Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations NGF CRH IL6 CRHR1 PMC4397892__F2 Inhibition of the classical apoptosis and autophagy pathway by Gamma-herpesvirus proteins FAS UVRAG PMC6683665__F5 Interplay between shrimp NFKB pathways and WSSV TRAF6 MYD88 PMC8771831__F3 Melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease GSK3B IRS1 PMC6683665__F4 Comparison of the shrimp IMD pathways (A) and Drosophila IMD pathways (B) and Human TNFR signaling (C) TRADD TAB3 FADD PMC6683665__F3 Positive and negative regulatory events in shrimp Toll pathways TRAF6 MYD88 PMC12090863__F1 Paclitaxel, interferons and functional reprogramming of tumor-associated macrophages in optimized chemo-immunotherapy CXCL9 CXCL11 IFNG CXCR3 HMGB1 CXCR1 CCR5 TLR4 CCL5 CXCL10 CXCR4 PMC6097677__F1 Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition TOPBP1 PCNA PERP PMC11065698__F1 5-LO-dependent oxylipin formation from ARA, EPA and DHA LTB LTC4S MGST2 PMC3999940__F3 Case study of the RegPhos-discovered phosphorylation networks involved in BCR signaling pathway SYK CD2 BTK CBL BCL10 BCR CDS1 CD22 BLNK CD19 LYN GRB2 PMC3177754__F4 RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity BCL10 NOD2 IRF3 IL1B CARD9 PMC6038340__F8 Intra-pathway feedbacks and BRAF/MEK growth-inhibitory synergism EGFR BRAF KRAS PMC7377942__F7 Mechanism of metformin‐mediated improvement of mouse oocyte apoptosis defects induced by arecoline BAX CASP9 HEL-S-128m HEL-S-2a CASP3 GPX1 HEL-S-44 PMC9113573__F6 Proposed mechanism by which proHp inhibits the TGF-Beta-induced EMT in SK-Hep1 liver cancer cells CDH2 SMAD1 DKFZp781O1323 SMAD2 PMC10031043__F1 Maintenance of genome integrity by the late-acting cytoplasmic iron-sulfur assembly (CIA) complex CISD2 MMS19 ABCB7 PRIM2 CIAO1 CIAO3 CIAO2B CISD1 DNA2 MUTYH RTEL1 NTHL1 POLE NDOR1 PMC11560026__F11 Mechanism by which SH3KBP1 impairs PRRSV replication, created in BioRender TBK1 MAVS TRIM25 IRF3 PMC7604490__F2 Genetic pathways implicated in vascular anomalies GNA14 ENG NF1 GNA11 BRAF KIT PTEN MTOR PMC1288263__F2 Mammalian sex determination: a molecular view WT1 SF1 SOX9 SRY PMC3764474__F1 SIRT1-dependent deacetylation of substrate proteins NMNAT1 NAMPT NMNAT2 SIRT1 NMNAT3 PMC7600400__F2 Reactive oxygen species (ROS) removal and effects PRX NNT HEL-S-44 PMC5390489__F5 Metabolic switch between MEP and MEC HEL-S-162eP PDC DAP PMC3290818__F1 TLR signalling pathway TLR3 TIRAP TLR4 IRF3 TRAF3 TRAF6 IRAK4 MYD88 PMC6636231__F2 Proposed working model of RGS proteins in the regulation of the Ca2+ oscillation-NFATc1 signal pathway for osteoclast (OC) differentiation RGS12 SIRPB1 OSCAR RGS10 NFATC1 PMC11889778__F1 NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H2S into the synovium PTCH1 SHH SMO PMC9274608__F3 Regulatory mechanisms and potential medical applications of HNF1A-AS1 in cancers MAP2K4 SERTAD3 PMC6332435__F1 An overview of cellular endocytic mechanisms CDC42 ARF1 ARF6 ARHA PMC9274608__F2 Regulatory mechanisms and potential medical applications of HNF1A-AS1 in cancers PBX3 OTX1 CTNNB1 PMC8198078__F2 Elevating the Levels of Calcium Ions Exacerbate Alzheimer’s Disease via Inducing the Production and Aggregation of Beta-Amyloid Protein and Phosphorylated Tau RYR2 RYR3 ORAI1 STIM1 TRPC1 PMC9369367__F1 Harnessing the Power of Purple Sweet Potato Color and Myo-Inositol to Treat Classic Galactosemia HEL-S-19 ATF4 EIF2A PMC3351834__F2 Transcriptional changes in TGFB1 signaling pathway SMAD9 SMAD2 SMAD4 MYC MAPK3 IFNG INHBB INHBA INHBE E2F4 ID4 LEFTY2 DCN BMPR2 ACVR2B ACVR2A ROCK2 ID2 TFDP1 TNF BMP6 RBX1 THBS4 BMP5 SMURF2 COMP TGFB1 BMP8B INHBC THBS2 RPS6KB2 ZFYVE9 THBS3 PPP2CA NODAL E2F5 TGFBR1 TGFBR2 FST NOG BMP4 AMH THBS1 SMAD6 BMP7 ARHA PITX2 GDF6 ID3 ZFYVE16 gdf7 BMP8A RPS6KB1 BMP2 SKP1 EP300 AMHR2 PMC8905584__F7 To detect potential pathways and target genes in infantile Pompe patients using computational analysis SIAH1 ROCK2 APC SMAD4 RYK ARHA BAMBI SOST INVS STOM NOTUM CER1 SKP1 NLK PMC8496196__F9 CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner CDC42 EPHX1 CDK14 PMC7323084__F4 Rationale for targeting complement in COVID‐19 C5AR1 HEL-S-62p ACE2 PMC8047423__F1 Complex regulation of HSC – and possibly hibernators – cell cycle entry CDK6 ULK1 FOXO3A JUNB CDK2 PTEN MTOR HES1 CDK4 PMC8465370__F5 Insights into Alexandrium minutum Nutrient Acquisition, Metabolism and Saxitoxin Biosynthesis through Comprehensive Transcriptome Survey ASL AMT OTC CP CIT PMC3177754__F3 RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity TRIM25 IRF3 PMC6269465__F1 Effect of SPPL2a deficiency on IFNG machinery SPPL2A APC PMC6475670__F5 Tumor necrosis factorA signaling in gastric cancer TRADD TRAF1 TNF TRAF2 FADD PMC4043736__F3 Patterns of Gene Expression Associated with Pten Deficiency in the Developing Inner Ear PVALB GAL TU3A ESPN PMC7870860__F1 Central role of self-nucleic acids in obesity-mediated metaflammation HMGB1 CGAS NLRP3 TLR3 TLR9 AIM2 IRF3 IRF7 TLR7 IL6 MYD88 PMC7926708__F8 Brief overview of the autophagy pathway, which is a catabolic process that includes a specific intracellular cargo, such as organelles or endosomal contents that are intended for degradation ATG3 ATG16L1 PIK3R4 ULK1 PMC8895457__F7 Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma BAX BCL2 MYC PMC6475670__F4 Interaction network showing miRNAs and their predicted and validated targets CASP8 TRADD NFKB1 NFKB2 CASP3 TNF TRAF2 PMC5377794__F6 Diagrams demonstrating the processing of Okazaki fragments DNA2 FEN1 POLE PMC9285942__F1 WNT/B‐catenin dependent transcription: A tissue‐specific business APC GSK3B CTNNB1 PMC7886502__F1 Regulatory effects of the estrogen-BDNF-mTORC1 signaling pathway in depression CORT CRH BDNF PMC3588029__F3 Regulation of PGC-1A—this schematic represents the relationship between nutrition, circadian clock and other regulatory factors involved in post-translational modification of PGC-1A and its consequent impact on metabolic genes and aging GSK3B NAMPT YY1 SIRT1 PMC8511346__F1 Sleep and Diet: Mounting Evidence of a Cyclical Relationship TPH1 AANAT TPH2 PMC3790664__F1 Comparing feedback mechanisms in morphogen signaling EGF DHRS3 PMC6980728__F3 NAD+ biosynthetic pathways and model for SARM1-mediated degeneration NNMT NRK NAPRT SARM1 NMNAT1 NAMPT NMNAT2 NMNAT3 PMC8320431__F1 Regulatory Roles of GRK2 in Endothelial Cell Activity and Pathological Angiogenesis ADRBK1 S1PR1 SMAD2 IL8RB PMC3138532__F1 HNSCC tumor microenvironment STAT3 EGF EGFR IGF1R GRB2 MTOR SRC PMC2194763__F5 Cell cycle pathway diagram obtained from GenMAPP (Gene Map Annotator and Pathway Profiler, Gladstone Institutes, University of San Francisco, San Francisco, CA [38] ATR TGFB1 CDC20 PCNA BUB1B CDC6 GSK3B SMAD4 TBC1D8 CCNA2 SKP2 PLK1 CCNH CCNB3 RB1 CCNE1 CCND2 CHEK2 ATM CCNB1 YWHAG ESPL1 TFDP1 MPEG1 MAD2L1 RBL1 PTTG1 CCNE2 PKMYT1 MAD2L2 PRKDC CDKN1B CHEK1 CDK2 EP300 UBE2F CDC25B PMC7155752__F3 Signal transduction in the early Drosophila follicle stem cell lineage SUFU SMO RAB23 PMC7155752__F2 Signal transduction in the early Drosophila follicle stem cell lineage EGFR APC MMP2 PMC8306262__F4 Statins: a repurposed drug to fight cancer IPP GPX4 PMC8306262__F3 Statins: a repurposed drug to fight cancer IPP HMGCR LDLR RHO PMC4573392__F1 Emerging concepts in the regulation of hematopoiesis by inflammatory signaling IFNG STAT3 MSC EPO PMC8122924__F2 Lipin-1, a Versatile Regulator of Lipid Homeostasis, Is a Potential Target for Fighting Cancer TF IGF1 IGF1R ARHA IRS1 PMC9445272__F8 CDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3B/Beta-catenin pathway GSK3B CDK9 CCND1 CTNNB1 PMC7242365__F4 GWSS host support of nutritional metabolisms in Sulcia-GWSS and Baumannia VIT PPCS GADL1 PAH THRA PPCDC COASY PMC8635159__F3 An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease OGA GNPNAT1 PMC5479992__F1 Iron homeostasis TFR2 FES HAMP HFE HFE2 PMC7663173__F5 YZT-mediated network analysis reveals UPS as potential target USP28 REST UBC IL12A CELF1 KRT14 IKBKE MARK1 HYDIN NEDD8 HMOX1 USP2 ATP6V0C TACR1 RIPK1 RDX UBB PMC7058704__F2 Autophagy regulation under various stresses NBR1 TAF1 ATG3 HEL-S-162eP PMC3926866__F1 Diagram of the steroid hormone biosynthetic pathway in the human adrenal cortex HSD3B2 CYP21A2 CYP17A1 CYP11B2 CYP11A1 PMC7058704__F1 Autophagy process ATG101 ATG10 ATG3 ATG12 ATG5 PMC8348198__F3A R-loop modulated epigenetic regulation in T helper cells mechanistically associates coronary artery disease and non-small cell lung cancer PIK3CA CSF1 SOS1 OSM CCL3 CXCL5 CCR5 TNLG7A CCL15 IL27 CCR2 IL33 CCL5 CCL2 CXCL8 CXCL3 MAPK3 IL-21 CCL23 PDPK1 IL16 CCL7 CCR8 CCL1 MAPK1 CSF2 CCL16 NAMPT B2M MIF IL1A IL10RA VEGFA TNF CXCL10 CCL13 CCL24 IL17C IL1RN BCL2 IL8RB GRB2 CCL8 BAK1 CCL20 IL10RB IL15 EGF CXCL12 TGFA RASSF1 EGFR CXCL1 CCL26 IL5RA BRAF CCR3 IGF1R CS CSF3 IL1R1 CX3CR1 IL1B IL17F CCL11 RPLP0 IL13 CXCL2 CD40LG IL17A IL5 KRAS TNLG2B HEL-S-162eP BMP2 CCR4 MAP2K2 TNFSF10 PMC8877168__F4 The NFKB Signaling Pathway Inhibitor BAY11-7082 in the Replication of ASFV TH REN NFKB2 CCL4 TRAF1 PTGS2 TNF IL1B PMC8408990__F2 Transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes APOC2 APOO APOC1 NECTIN2 SCIMP CLU CD2AP APOC4 PVRIG PMC3391249__F8 Defence Signalling Triggered by Flg22 and Harpin Is Integrated into a Different Stilbene Output in Vitis Cells MSC FLG HP PMC5335504__F9 Proposed model for the role of ADAP2 in antiviral response TBK1 MAVS IRF3 ADAP2 TRAF3 PMC8172903__F1 STING1 network regulates autophagy and cell death CGAS NFKB1 IRF3 MITA PMC6436758__F7 Cellular response to small molecules that selectively stall protein synthesis by the ribosome ZNF622 NEMF ASCC1 PELO HBS1L LTN1 ASCC2 EIF6 PMC8172903__F3 STING1 network regulates autophagy and cell death BAX CASP9 TBK1 CGAS CASP8 MLKL CYCS IRF3 TNF RIPK3 BCL2L1 NFKB1 CASP3 BAK1 APAF1 FADD PMC8172903__F2 STING1 network regulates autophagy and cell death TBK1 ULK1 WIPI2 SQSTM1 MITA MTOR ATG5 PMC11854789__F1 Mechanism and Applications of Vagus Nerve Stimulation STAT3 BAX GDF11 BDNF TNF PMC4658161__F7 Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NFKB Signaling SHARPIN EYA2 RNF31 PTEN EYA1 PMC2722148__F1 MAPK transduction signaling pathway MAP3K1 GRB2 FGFR2 PMC3814597__F2 General activation of interferonB (IFNB) transcription and induction of IFN-stimulated genes STAT1 STAT2 IRF9 IRF3 JAK1 TYK2 PMC8306508__F5 Acquisition of New Migratory Properties by Highly Differentiated CD4+CD28null T Lymphocytes in Rheumatoid Arthritis Disease CDC42 ABI2 HEL114 LPA ARHH VASP F2R THY1 APC F3 ARHA RAC1 PMC7060471__F2 Pharmacological manipulation of the activity of Wnt/B‐catenin signaling pathway PORCN TNKS APC CTNNB1 PMC7060471__F1 A, Position frequency matrix of the T‐cell factor (TCF) motif was obtained from the JASPAR database (http://jaspar.genereg.net) TF HAL CTNNB1 PMC3824408__F1 Unveiling the last missing link of the cardiolipin synthetic pathway in mitochondria ART5 PGS1 PGP CDS1 PMC5088199__F1 Cellular pathways currently being targeted in the treatment of endometrial cancer (EC) and the potential actionable genes in EC identified via Next Generation Sequencing (NGS) ARID1A POLD3 PIK3CA BAD POLE2 PTEN PPP2R1A KRAS FBXW7 POLE4 RXRA POLD4 MDM2 POLD2 POLE PMC4079587__F5 Interaction of kisspeptin, estrogen and BMP-4 in regulation of GnRH production by GT1-7 cells SMAD1 DKFZp781O1323 BMP4 SMAD6 PMC4726671__F1 Hepatitis C virus life cycle CD81 NPC1L1 EGFR APOE LDLR RHO CLDN1 PMC4077471__F3 Examples of pathway engineering and combinatorial biosynthesis to generate new analogs: A TEC HAL PMC9126881__F8 M2 macrophage-derived extracellular vesicles (EVs) on the development of ankylosing spondylitis (AS) through by transferring of microRNA-22-3p PER2 WNT7B RUNX2 CTNNB1 PMC8462485__F9 Oridonin Prolongs the Survival of Mouse Cardiac Allografts by Attenuating the NFKB/NLRP3 Pathway CD40 CD80 NLRP3 TLR4 IL1B PMC5499174__F1 The assayed components of the IIS/TOR pathway and their proposed interactions in D RHEB TSC1 SIK2 PTEN MYC PMC3745370__F8 High expression of the ppGalNAc-T13 gene enhances cancer metastasis by formation of trimeric Tn antigen ITGB1 TTN SDC1 PMC4276719__F10 Fatty acid metabolism in bacteria MCAT AASS FADD PMC7796222__F5 Postulated metabolic pathway of Alpha-PHP and 4F-Alpha-PVP F5 F2 F3 PMC4867327__F9 Schematic diagram illustrating lipid droplet formation, VLDL secretion, and pathways involving hepatic inflammation TG MTTP SMS NLRP3 COX2 PEMT APOE PC APOB ADFP HEL-S-70p IL1B PMC2864659__F6 APE1 has dual roles in redox and DNA repair TF OGG1 EGR1 HLF PMC9197245__F7 Strontium Regulates the Proliferation and Differentiation of Isolated Primary Bovine Chondrocytes via the TGFB/SMAD Pathway ACAN SMAD9 SMAD1 ALPL TGFB1 DKFZp781O1323 SMAD4 COL10A1 RUNX2 COL2A1 SPP1 PMC6491380__F9 Reversion of HIV-1 latency regulated by DCs CD83 CD81 TSC2 TSC1 CD9 PI3 CDS1 CD151 PTEN PMC8613610__F2 Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease AMICA1 SPNS2 ABCG1 ABCC1 PC CS ABCA1 PMC6652211__F6 Possible EPO signaling pathway EPHB4 PLCG1 BCR EPOR EPO PMC2683382__F2 Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites TEC STAT3 IL25 TSLP IL17RB IL33 TRAF6 IRAK4 MYD88 PMC3730428__F8 Schematic diagram summarizing the key findings CASP8 TRADD CASP3 RIPK1 TNF TRAF2 FADD PMC3906322__F2 STAT2 and IRF9 TBK1 MAVS STAT2 IRF9 IRF3 ATF2 DUOX2 TRAF6 DUOXA2 STAT1 RIGI IFNAR2 IFNAR1 JAK1 TYK2 UNK PMC6163297__F6 Schematic drawing of the possible signalling pathways regulated by PACAP in bone formation BMP6 SMAD1 DKFZp781O1323 PTCH1 SHH SMAD4 IHH BMP7 SMO RUNX2 PMC5814345__F6 Ezrin mediates both HGF/Met autocrine and non-autocrine signaling-induced metastasis in melanoma HGF SP1 PMC7961955__F7 Common signaling pathways in liver disease (primarily HCC) and the kinase inhibitors aimed at these pathways FLT3 AXL EGFR KIT MTOR SRC RET PMC2080843__F5 Simulation of the Apoptosis pathway under FasL stimulation (black starred line), bacterial only (red circled line) and both (blue triangled line) BAX CASP9 CASP8 CASP3 PMC5986551__F5 Network analysis of differentially expressed genes in glioma cells exposed to exosomes C1QTNF2 DRGX KCNJ3 CSF2 PAPPA2 XCL1 CCL2 CSF3 CXCL8 KCNT2 IL1B PMC4977841__F1 Hedgehog signaling inhibition by the small molecule Smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b SUFU SHH SMO PMC10151263__F8 Grain-sized moxibustion at Zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK/mTOR signaling pathway ULK1 TFEB TRPV1 MTOR PMC3360921__F8 IQGAP1 regulates cell homeostasis through mTORC1 CDC42 EGF IQGAP1 MTOR PMC5986551__F2 MS and network analysis of hypoxic exosomal proteome HNRNPA0 COPE RPS14 PPM1G PRPF8 RPS3A LOX NPM1 MMP3 HNRNPK HDAC2 HNRNPAB FBN1 ROCK2 EIF3K RPS4X HEL-S-133P EIF3A NAMPT MIF SMC1A RPL19 HGS SF3A2 RPL23A LOXL2 RPS27L HNRNPA2B1 MVP HSPA4 EN1 LAMB2 EIF3B LMNA HEL113 NFKB2 EIF3L PML GRN HEL-S-97n PSMD2 CCAR2 TPR EIF3S3 PRKCSH PIG59 RPS3 COPB2 COPS4 RPS6 THBS1 FASN SCAMP3 RRBP1 FKBP4 HEXB SERPINE2 HEL-S-162eP PRKDC EIF3C SH3BP4 BMPER RPS9 PS1TP5BP1 HEL-S-1a PMC6235777__F1 Graphical representation of IFNG signaling pathway RARA BOC DAP AREG SRC FOS PLAA PMC8016451__F8 Schematic diagram showing the mechanism by which Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis HMGCS1 HMGCR LDLR PMC9025063__F6 Genome Integrity and Neurological Disease RAD51 DNA2 PAXX BRCA2 ATM BLM RBBP8 EME1 PMC11648684__F10 Main mechanisms involved in the regulation of oxidative stress by m6A TFAM ABCA5 DGCR8 PRDX3 HECTD4 KEAP1 WTAP METTL14 COX5A METTL3 NRF1 SLC22A17 PMC9025063__F5 Genome Integrity and Neurological Disease XPA LIG1 POLE XPC PMC10198048__F7 Working model of how Cas regulates osteoclastogenesis DCSTAMP CTSK NFATC1 MMP9 TRAF6 PMC4499510__F1 WNT/Beta-catenin signaling pathway TNKS APC GSK3B LRP5 LRP6 CTNNB1 PMC9025063__F4 Genome Integrity and Neurological Disease LIG1 FEN1 PCNA PARP1 PMC8798237__F4 Key genes involved in cell cycle arrest and DNA damage repair identified in anaplastic thyroid carcinoma using integrated bioinformatics analysis ATR AIFM2 CASP3 CDK2 ATM CYC1 PTEN PIGS MDM2 MYC PMC2639448__F1 Intrafollicular predictors and regulators of oocyte quality within the oocyte–somatic cell regulatory loop BMP15 SMAD1 DKFZp781O1323 SMAD2 GREM1 HAS2 PTGS2 GDF9 PMC5445212__F1 Endosomal transport channels and regulation of lipoprotein-derived cholesterol in hepatocytes.In many models, it was thought that cholesterol from all sources would enter a common regulatory pool before subsequent trafficking and regulatory steps ABCG8 ABCG5 HMGCR ACAT2 LDLR ABCA1 PMC8047423__F2 Molecular mechanism governing cell quiescence and torpidity in contrast with cell proliferation and euthermia TF PDK4 TSC1 PML MEIS1 PTEN PDK2 MTOR PMC11648684__F11 M6A is involved in regulating the immune function of innate immune cells neutrophils, macrophages, NK cells and adaptive immune cells T cells and B cells WNK1 TNC NLRP13 ALKBH5 METTL14 YTHDF2 METTL3 NOTCH2 PREB PMC140192__F7 Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF EGFR SMAD2 SMAD4 NODAL PMC4884928__F4 Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state MYB RAN CSF1 RB1 KLHL12 EZR PES1 IL16 MFN2 POMC SHH NPY GLB1 MAPK1 UGT1A3 DEFB4B PFKFB4 DKC1 IRF7 OAS3 VEGFA TNF FOS UGDH RUVBL1 MCM3 BDNF EGF HEL-S-62p PPP1CC CTNNB1 CYP2C19 CYFIP2 BMP4 IFITM3 IL18 APP MX1 CCND1 MYL6 JUN CFD SUPT20H PTPN11 PTGS2 ARHA CCNC MT2A ITGA1 RHOB MTF1 IKBKB SKP1 PMC3159954__F3 Antiretroviral Therapy Down-regulates Innate Antiviral Response Genes in Patients with AIDS in Sub-Saharan Africa RBX1 ISG15 PMC3159954__F2 Antiretroviral Therapy Down-regulates Innate Antiviral Response Genes in Patients with AIDS in Sub-Saharan Africa STAT2 PSMB8 IRF9 IFIT3 JAK1 TYK2 PMC7763666__F5 Wingless-type (WNT) signaling pathway HDAC1 JUN MAP3K7IP1 DKK1 APC HEL-S-28 MDM2 NLK SRC SFRP1 PMC8798237__F3 Key genes involved in cell cycle arrest and DNA damage repair identified in anaplastic thyroid carcinoma using integrated bioinformatics analysis CDC2 DBF4 PCNA MAL CYC1 MYT1 SKP2 ORC2 CDK7 E2F4 CDC45 CDK2 HP MDM2 PMC4815022__F4 Identified signaling pathways downstream to glycine in NSCs TGFBR2 BMP6 GNA14 CASP8 HHIP CDKN1A SESN3 SHH CAMK4 SESN1 SESN2 WIF1 PMC4884928__F5 Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state STAT3 CASP9 STAT2 IRF9 CYCS HIF1A IRF7 IL6 CSNK2B STAT1 BCL2L1 IFITM3 ISG15 EIF2AK2 PMC7596088__F3 Role of TGFB, IL-6, and IL-1B signaling pathways in PDAC EMT CXCL12 CCL20 IL1B PMC5567228__F6 Wnt/FZD4 signaling pathways through the interaction of miR-204 with FZD4-miR-SNP (rs713065) variant in NSCLC cells F11R FRZB TGFB1 ETS2 APC NRP1 LRP6 DVL2 TCF4 IL6 MYC RAC1 SFRP1 CTNNB1 CD44 MAP3K7IP1 DKK1 CALM1 HPRT1 NLK MDM2 SRC CCND1 WIF1 PMC8865078__F7 Transforming Growth Factor-Beta-Regulated LncRNA-MUF Promotes Invasion by Modulating the miR-34a Snail1 Axis in Glioblastoma Multiforme SMAD2 SMAD4 CAPRIN2 PMC8472533__F1 New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment LATS1 PMC7559338__F6 Experimental verification of TFAP2C regulating EGFR in A549 cancer cells EGFR TFAP2C MAP2K2 KRAS PMC10759702__F7 Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy IFNG STAT3 CEBPA JUN SP1 TLR3 NFKB1 IL6 TNF CEBPB IL1B PMC5298863__F4 Intracellular signalling pathways that are activated by insulin and amino acids after feeding and that lead to the activation of translation initiation in the immature skeletal muscle RHEB RPS6 TSC2 RICTOR TSC1 PTEN MTOR EIF4E PMC9344793__F3 Cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics LPL ABCG1 ACAT1 ABCG8 ABCG5 CD36 ACAT2 LDLR ABCA1 SRA1 PMC6590595__F1 WNT signaling model APC GSK3B CTNNB1 PMC8577929__F1 Target Sestrin2 to Rescue the Damaged Organ: Mechanistic Insight into Its Function TSC2 KEAP1 ULK1 IL6 PMC6618143__F3 Macrophage metabolic pathways ACLY PFKFB1 FAS IL16 ACOD1 SUCNR1 ARG1 PMC10375641__F5 Super-enhancers complexes zoom in transcription in cancer MAX EGFR SOX2 MYC FOS PMC11364386__F1 Blockade of secretory vesicle biogenesis provides a therapeutic strategy for targeting cancer GOLPH3 GOLIM4 ATP2C1 PLAUR PMC4419472__F9 Schematic diagram describing the effect of oroxylin A on the inhibition of p53 degradation through the suppression of PTEN-regulated MDM2 expression SIRT3 PTEN MDM2 PMC8089133__F4 Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study POR TBK1 MALL COX2 TAB3 MDP1 TNF TRAF2 CD47 FADD PMC8452151__F4 Mechanisms that decode combinatorial and temporal codes of pathway activity to achieve stimulus-specific responses ATF3 CEBPD IRF3 IFNB1 TNF PMC9313267__F2 Mechanism and Role of ADAMTS Protein Family in Osteoarthritis VIP NOS2 COMP PMC8452151__F2 Molecular mechanisms for combinatorial encoding to achieve stimulus-specific responses MAVS TRADD TIRAP TLR3 TLR4 IRF3 MYD88 PMC8588641__F7 Umbilical cord blood plasma-derived exosomes as a novel therapy to reverse liver fibrosis SMAD2 ID1 PMC2949386__F6 Preclinical Evaluation of Novel Triphenylphosphonium Salts with Broad-Spectrum Activity STAT3 JUN HGF RAF1 PXN CRKL PTPN11 GRB2 PTGS2 FOS PMC6110613__F2 Exploiting vita-PAMPs in vaccines ICOS IL1R1 IL16 TLR8 CXCR5 IL1B PMC4493053__F7 Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition SUFU PTCH1 GSK3B SHH SMO PTEN MTOR PMC2731733__F5 Cytoskeletal Remodeling: FAK Signaling pathway is enriched for HeLa and TOV edge hits using PIPA but not node hits using HGA enrichment CDC42 HRAS FARP2 GSK3B ARHA TRAF3 RHO SHE PMC4450261__F1 Activation of the Keap1-Nrf2-ARE pathway by oxidants/electrophiles KEAP1 MAF PMC5945923__F1 Cross talk between E2–estrogen receptorA (ERA) signaling pathways and circadian rhythms in breast cancer TF PER2 MMP2 SRC PMC7179206__F6 (−)-epicatechin anticancer activity in MDA-MB-231 and MCF-7 cells HTRA2 BAX BAD PMC5528412__F1 Simplified representation of the PI3K signaling pathway RHEB TSC2 INPP4B PI3 PTEN PMC5536354__F7 Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes EGF BAD EGFR PAX2 RHO PMC2722335__F1 Adipocyte lineage commitment and terminal differentiation LOX BMP4 BMP2 PMC10706592__F3 TRAIL signaling pathway indicating the therapeutic targets modulated by flavonoid compounds FADD PMC10706592__F1 TRAIL signaling pathway BAX FADD PMC9414016__F1 Dual role of fucosidase in cancers and its clinical potential FUT1 FUT4 FUT8 FUCA1 FUT6 FUT2 POFUT4 FUT3 FUT5 POFUT2 FUT7 GMDS POFUT3 POFUT1 FUCA2 FUT9 PMC6295312__F1 Gene-level alterations in muscle-invasive bladder cancer in the context of curated pathways FAT4 FLT3 RAF1 SOS1 KEAP1 SMAD2 GSK3B SMAD4 MYC AMER1 FGFR2 RB1 CDKN2A FBXW7 CDK6 CSNK1E CCNE1 ALK NF1 NCOR1 ERRFI1 FGFR1 RIT1 MAPK1 TAOK1 TAOK2 MXD1 MNT APC LRP5 PCDHJ YAP1 RHEB ERBB3 RICTOR TCF7L2 TSC1 CDKN1A PSEN2 AXIN1 MAX DKK4 STK11 STK4 TGFBR1 TGFBR2 MGA MDM4 MAML3 CCND2 INPP4B MLX JAG2 NF2 MXI1 CCND3 CRB1 ERBB4 KDM5A KIT PPP2R1A RAC1 AXIN2 SFRP1 ARAF CBL ARRDC1 WWC1 PDGFRA TAOK3 CREBBP ERBB2 EP300 CRB2 DKK1 FGFR4 MYCL MDM2 ROS1 ACVR2A CSNK1D TLE4 CDKN1B FAT1 ZNRF3 RET EGFR BRAF IGF1R PTEN CDKN2B MTOR DCHS1 CTNNB1 TLE2 LATS1 MOBKL1A TEAD2 ACVR1B ATM DKK2 CCND1 DNER MLXIP CDK4 RPTOR SPEN TLE3 PTPN11 DKK3 RNF43 NTRK1 FGFR3 RPS6KA3 MAP2K1 MAP2K2 FAT2 FAT3 KAT2B WIF1 PMC6152364__F4 Relation between mammalian MAPK cascades and other kinases capable to induce cell responses involved in cancer CDC42 MTOR RAC1 PMC9120629__F1 Complement Dependent Synaptic Reorganisation During Critical Periods of Brain Development and Risk for Psychiatric Disorder C6 C7 C2 C1S C9 CS C4B_2 PMC7479251__F4 Notch signaling pathway, including targets and drugs that could be employed to inhibit it DLL4 JAG2 DLL3 RBPJ PMC7479251__F6 Hippo pathway including targets and drugs that could be employed to inhibit it LATS1 LATS2 NF2 PMC7479251__F5 Sonic Hedgehog canonical signaling, including targets and drugs that could be employed to inhibit it KIF7 SUFU GSK3B PMC8526190__F1 Neutrophil Extracellular Traps (NETs): Opportunities for Targeted Therapy CS MPO PMC7479251__F7 TLRs pathway including targets and drugs that could be employed to inhibit it TBK1 TLR9 IRAK1 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC3049553__F1 MAPK pathway activation in melanoma NRAS PTEN GRB2 MTOR SRC PMC8602415__F7 Transcriptome analysis reveals that long noncoding RNAs contribute to developmental differences between medium-sized ovarian follicles of Meishan and Duroc sows THBS1 ITGB1 ITGB4 ITGB7 ITGA6 MDM2 PMC8602415__F6 Transcriptome analysis reveals that long noncoding RNAs contribute to developmental differences between medium-sized ovarian follicles of Meishan and Duroc sows DUSP5 ATP2B3 PARP15 RAB40C ENY2 CRYBA4 TNFRSF8 GNAS ALOX5 GPR82 TMEM218 FGFR1 LEFTY2 TRIB3 TNFRSF12A SLAMF8 RAVER2 AREG DUOX2 CYP1A1 B3GALT1 SPP1 RAD21 SERP2 SCARB1 DIPLA1 NRIP2 NRIP3 PMC8211227__F3 Schemetic drawing of carbon fixation in photosynthetic process (adapted from KEGG pathway zma00710) ME3 PCK2 ME2 PDK2 PMC3060875__F3 Acute Endotoxin-Induced Thymic Atrophy Is Characterized By Intrathymic Inflammatory and Wound Healing Responses JUN SP1 CCL7 CCL20 FOS PMC3060875__F5 Acute Endotoxin-Induced Thymic Atrophy Is Characterized By Intrathymic Inflammatory and Wound Healing Responses ZAP70 CD80 FYN LAT VAV1 GRB2 LCK PMC4959673__F6 HRPII recognition by human brain endothelial cells and the intracellular pathway that leads to BBB leakage VCAM1 IL1B MYD88 PMC8399750__F1 Nrf2 Pathway in Ischemic Stroke: A Review IL17D KEAP1 CD36 ULK1 NQO1 MAF MARCO CALCOCO2 PMC7262827__F6 KEGG pathway analysis of differentially regulated genes in MCF7 cells after treatment with isopicrinine alkaloid, depicting the affected genes that play significant role in cell cycle and cell proliferation DBF4 CDK7 PCNA E2F4 SMAD2 GSK3B SMAD4 CDK2 MYT1 ORC3 SKP2 PMC9500598__F2 Circular RNAs Involved in the Regulation of the Age-Related Pathways RHEB TSC2 TSC1 INSR TRIL GSK3B PTEN MDM2 MTOR INS DEPTOR PMC9500181__F1 Molecular mechanism of ferroptosis and its role in the occurrence and treatment of diabetes SLC3A2 KEAP1 GPX4 LPCAT3 FACL4 SLC7A11 DHODH PMC7262827__F5 KEGG pathway analysis of differentially regulated genes in MCF7 cells after treatment with isopicrinine alkaloid, depicting the affected genes in p53 signaling pathway RFWD2 CASP9 TSC2 ATR PERP SUI1 CASP3 FES CDK2 ATM PTEN MDM2 PMC7602998__F1 Events after colorectal surgery leading to AL MBP FPR1 IL1B MYD88 PMC3652374__F4 PPARG as a key regulator of lipogenesis in adipocytes and hypothetical major target for inhibitors of insulin-stimulated lipogenesis in obesity IFNG FAS IL1B PMC7016007__F7 Crosstalk of metabolic pathways in AMD RPTOR HEL-S-32 PARP2 SIRT1 PMC3426783__F4 IPA network analyses were applied to differentially expressed genes in mouse brain after in vivo ketamine exposure CYP51A1 TNNC1 TNNT3 PAX4 LDB1 AREG GJB1 TRIM63 CBFA2T3 IGF2R FOSL2 NR2A1 CRB3 PI3 NKX2-2 NEUROG1 PRPF38B ITGA6 ZMYND19 PNMA1 PRKG1 PMC4593152__F4 Conditional probability and local structure extracted from the simplified network, for calculating the indirect effect of this specific pathway (NAFLD, GGT1, GGT2, dyslipidemia, hypertension and MetS) PMC3652374__F2 Insulin signalling exerts rapid stimulation of glucose transport as well as fatty acid uptake, synthesis and esterification to triacylglycerol (TG) LPL TG FAS PMC3652374__F1 Insulin signalling attenuates cAMP-mediated lipolysis at multiple steps in adipocytes TG PDE3B GRB10 INSR PLIN1 PDE5A IRS1 PMC5891907__F1 Scheme of the innate immune response to injury TLR4 IRF3 CCL2 MYD88 PMC5466160__F1 Autophagy pathway ATG10 ATG3 ATG12 ULK1 ATG5 PMC8800599__F1 Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy CSA2 NLRP3 KEAP1 PMC4533772__F3 Analyses of interactions among SHRSP-specific genes VEGFB BANP APOH RYR1 AGTRAP GABRR1 ZBTB16 CYP1A1 CCR1 EPHX2 PMC5098802__F2 Injury site-specific targeting of complement inhibitors for treating stroke CRP CAD HEL-S-62p PLG CR1 PMC4765310__F2A Importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes TBK1 TAB3 IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC3721730__F2 TRAIL-mediated extrinsic pathway of apoptosis HDAC7 FADD PMC11436262__F4 PPM1G participates in the occurrence and development of hepatocellular carcinoma and liver fibrosis via different pathways PRMT1 CASP8 SFRS3 NOTCH3 HES1 PMC3721730__F1 Intrinsic and ER pathways of apoptosis BAX BAD PMC11436262__F3 PPM1G-associated signaling pathways TSC2 TSC1 PPM1G ID1 PMC4533772__F2 Analyses of interactions among SHR-specific genes TSPAN1 TP73 JUN CYP24A1 GDNF PCDH9 SOX2 RXRG NEFH ITGA1 APOH GC SPIB CFTR AGTRAP ZBTB16 ANKRD35 BCL6 EPHX2 PMC11881679__F2 AAT is involved in the regulation of the cell signaling pathways and the pathogenesis of disease TAB3 GRB2 TRAF6 TRAF2 IRAK4 STS FADD MYD88 PMC5841291__F8 Sotetsuflavone inhibits non-small-cell lung cancer cell invasion and metastasis CDH2 MTOR PMC5083753__F3 Anticancer and analgesic activities of B‐caryophyllene (BCP) and B‐caryophyllene oxide (BCPO) STAT3 BCL2 MTOR PMC2953155__F5 Model schematic of Nipah virus-triggered DC immune response mechanisms and antagonist activity of the response CCL4 IRF7 JAK1 TYK2 PMC10471462__F2 Hippo pathway is involved in T cell development MOB1A STAT3 MOBKL1A DOCK8 FOXO1 FOXO3A F3 FOXP3 RAC1 PMC6461132__F1 PRR signalling pathways SYK MAP3K7IP1 NLRP3 BCL10 PLCG2 RP2 NOD2 IRAK1 IRF3 NOD1 TRAF3 PMC10471462__F1 Hippo pathway is a signaling pathway that regulates the self-renewal and differentiation of hematopoietic stem cells (HSCs) LATS1 CDC42 LATS2 RUNX1 RHO NF2 PMC6461132__F3 Negative Regulation of PRR-induced signalling NOS2 SYK NLRP3 BCL10 PMC10471462__F3 Hippo pathway is involved in megakaryopoiesis (upper panel) and erythropoiesis (bottom panel) INHBA FSTL1 ARHA MDM2 CD34 PMC4083854__F2 Diagram showing the effects of knockout or blockade of specific elements of the alternative, classical and lectin pathways of complement activation on the pathogenesis of anti-MPO induced murine crescentic glomerulonephritis MASP1 C6 MASP2 HEL-S-62p C4A PMC11019012__F2 Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy BAX BAD FADD PMC8087671__F3 Proteomic and phosphoproteomic profiling of shammah induced signaling in oral keratinocytes FAS OSM MLKL IL33 ADH5 GLUD1 PYGL ALDH1A3 PIG59 LOX NLRP3 ZBP1 TLR4 RIPK1 USP21 CYLD BAX HMGB1 TRPM7 HEL-S-133P H2AX LDHB HEL-S-30 TNF PARP1 RIPK3 TLR3 HEL-S-68p PFKP HEL-S-162eP HEL-S-49 BCL2 TRAF2 FADD PMC7813674__F1 NFKB signaling pathway TRADD TAB3 TLR9 IRAK1 TLR5 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TLR4 TRAF5 TLR8 TLR7 TRAF2 PMC8558653__F5 Mucin 1 promotes tumor progression through activating WNT/Beta-catenin signaling pathway in intrahepatic cholangiocarcinoma MMP7 MUC1 CCND1 CTNNB1 PMC9646327__F8 Virtual Screening and Network Pharmacology-Based Study to Explore the Pharmacological Mechanism of Clerodendrum Species for Anticancer Treatment HEL-S-22 PRLR AURKA PIK3CA PGR EGFR BRCA2 TERT MTOR TGFBR2 ALK PDPK1 COIL CHEK2 PRKCA FLT1 KDR SRC KLK3 MMP9 HEL-S-30 HRAS CD44 BRCA1 CASP3 FGFR3 TNFSF10 PMC3759173__F3A Microarray Analysis in a Cell Death Resistant Glioma Cell Line to Identify Signaling Pathways and Novel Genes Controlling Resistance and Malignancy RYR2 HLA-DMB TNFRSF19 ANK2 KYNU HLA-DOA LY96 HLA-DMA HLA-DRA MAP3K7 LCN2 CRADD NFKBIZ PMC3469060__F6 Putative mechanisms responsible for UPR activation by CD147 in human HCC cells TF HIF1A YY1 PMC7526978__F2 Z-nucleic acid-dependent inflammatory signaling pathway RIPK3 ZBP1 MLKL RIPK1 PMC8042276__F4 Epigenetic Modifiers: Anti-Neoplastic Drugs With Immunomodulating Potential TET2 SMAD2 EZH2 IL17A TBX21 GATA3 HDAC1 IFNG KDM6B HDAC5 HDAC11 FOXP3 SIRT1 PMC7924357__F1 Angiogenesis pathways in malignancy and targeted therapies commonly used EGF EGFR MTOR PMC9059429__F1 Rodent Genetic Models of Ah Receptor Signaling AHR AHRR CYP1B1 PMC7920551__F8 Model depicting lymph gland progenitor heterogeneity and response to immune challenge LAT TERT PMC3852779__F2 Hepatic genes differentially regulated by 17Beta-trenbolone: Impacts on metabolic pathways CYP51A1 CYP2A13 CYP24A1 CYCS CYC1 CYP4B1 MPO DOCK2 PROX1 EPX TDO2 CYGB CYP2C9 CYP46A1 CYBA MB CYP3A4 SDHC CYP27A1 CYBB PMC6941129__F4 Regulation of the G1/S transition by the Greatwall-Endosulfine-PP2A/Cdc55 pathway in budding yeast CDC2 CDK2 CLN3 PMC9451157__F5 Pathway and mechanism analysis of F1-mediated chemoenzymatic synthesis of benzimidazole C4A SET PMC4663159__F7 The integration of the DUOX2 system into the intestinal epithelial defense response REG3G APC CXCL1 DUOX2 CCL20 PMC12109299__F1 HER2 signaling TSC2 TSC1 EGFR PTEN PMC6723600__F1 IL-38 signaling pathways IL1R1 SIGIRR MYD88 PMC11478363__F5 Research Progress on the Mechanisms of Protocatechuic Acid in the Treatment of Cognitive Impairment BAX CASP9 STAT1 MAP2K4 CASP3 BCL2 MAP2K1 SIRT1 MYD88 PMC6321632__F2 mRNA translation stress feedback to ribosome biogenesis and cell proliferation POLI MTOR PMC7367634__F6 Resistance mechanism to vemurafenib NF1 NRAS PTEN MTOR PMC8732282__F8 Proposed model depicting the therapeutic mechanism of GRB7-PLK1 axis inhibition to overcome MEKi resistance in KRAS mutant colon cancer cells STAT3 GRB7 PLK1 PMC3905281__F5 Wnt signalling pathway in developing muscle-less humeri PRG4 SALL1 CPZ EPHA4 GREM2 RSPO3 RXRG PITX2 SNAI3 CCNB3 CTNNB1 CD44 ELAVL2 FGF7A PITX3 JAG2 DKK2 CACNG1 TNIK TCF15 KCND1 ISLR2 CLDN1 PMC11677171__F2 Molecular mechanisms responsible for the suppression of T:B cell cross-talk in inflamed glandular tissues STAT3 FAS MSC FOXP3 PMC3516044__F3 Changes in the Plasmodium falciparum redox flux network after MB drug action.Notes: Results incorporating the transcription data and experimental mRNA expression data nine hours after incubation with methylene blue are shown POTEE RET PMC3759173__F4A Microarray Analysis in a Cell Death Resistant Glioma Cell Line to Identify Signaling Pathways and Novel Genes Controlling Resistance and Malignancy CSF2RA JDP2 ID2 CTSK F8 IFI16 LPXN PMC11677171__F1 Effects of MSC-derived immunomodulatory and growth factors on survival, migration, phenotype and function of immune cells and parenchymal cells in inflamed and injured lacrimal and salivary glands BAD HGF MSC FOXP3 PMC5843896__F7 Our working model KEAP1 GSK3B CTNNB1 AQP1 PMC8099467__F4 Transcription factor networks of oligodendrogliomas treated with adjuvant radiotherapy or observation inform prognosis CREB3L3 PER2 PER1 CRY1 VHL PMC8087671__F2 Proteomic and phosphoproteomic profiling of shammah induced signaling in oral keratinocytes MLYCD DBP HMGCL DMP1 LOC51064 PEX6 NUDT19 PEX5 PIPOX PEX2 PXMP4 PEX16 PEX10 PEX3 PEX12 DAO PEX26 PEX13 PEX14 PEX7 PTS PECR AMACR PHYH EPHX2 CRAT MPV17 NUDT12 MVK CROT PMVK CD36 FREM1 FRAS1 FREM2 PAOX VTN NUDT7 CHAD BAAT PRDX5 VWF PXMP2 AGPS ddo CD47 CD44 DHRS4 XDH PMC5159197__F1 IgA Nephropathy Enigma GAL CIC C1GALT1 PMC1599906__F3 TGFB signaling pathway TF HDAC1 SMAD1 DKFZp781O1323 SMAD2 BMP4 BMP2 SMAD6 SMAD4 BMP7 NODAL GRB2 PMC6097464__F5 Focal adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set BAD PXN VAV2 EGFR PTEN ACTN2 LAMC1 FLNA ITGAV SHC4 FYN CCND2 ITGA2 MYL2 PRKCA BIRC3 CCND3 PDGFD CAV2 THBS1 LAMC2 PARVA TLN2 HEL-S-28 LAMB4 LAMA4 MAP2K1 PMC11062983__F7 pDNA-tachyplesin treatment stimulates the immune system and increases the probability of apoptosis in MC4-L2 tumor cells STAT3 BAX IL6 IL6R PMC6097464__F7 TGF-beta signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set LTBP1 BMPR2 ARHH TH THBS1 TNF E2F5 BAMBI SMURF1 INHBA ACVR1 FST NOG HEL-S-11 SMURF2 PMC8313741__AF1 miR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression SOX2 SIRT1 PMC6097464__F6 MAPK signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set MAX NAT2 DUSP10 TGFB1 NFATC2 EGFR MAK RELB PTEN TNF CACNG4 FLNA MEF2C IKBKG FGFR2 PRKCA FGF20 RRAS DUSP14 PMC6097464__F9 Focal adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set BAMBI GP1BB LTA THBS1 LAMC2 FST UNG LAMC1 TNF LAMA3 ITGAV PMC6097464__F8 TGF-beta adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2404 set FAS MAK RPSA SOS2 PTEN ATF2 DUT SLK PMC4935144__F1 Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway RHEB TSC2 GRB10 TTI1 MTOR DEPTOR IRS1 PMC7367634__F1 MAPK and PI3K‐AKT‐mTOR signaling pathways BRAF IGFBP7 MTOR PMC8455332__F1 Suppressive actions of regulatory T cells CD80 APC CTLA4 PMC4015186__F1 MiRNA Regulation of the Human Glycome NAGPA GNPTG ALG11 MAN1B1 ALG3 GANAB DPAGT1 GNPTAB MGAT4C GCS1 PRKCSH ALG6 ALG10 MGAT3 ALG13 MGAT2 ALG1 PMC7907026__F2 Diverse roles of the immune checkpoint in tumor cells that drive to the stimulation or inhibition of metastasis STAT3 BAX NOS2 EGFR BTLA MTOR CD47 PMC4015186__F4 Insights into MiRNA Regulation of the Human Glycome FUT2 ABO PMC4556941__F2 Key mechanisms regulating vascular smooth muscle tone ADRB1 CNP PMC11481580__F7 Transcriptome sequencing analysis of overexpressed SikCDPK1 in tobacco reveals mechanisms of cold stress response MKS1 RAN MAK MYC BAK1 PMC6249818__F6 Therapeutic targeting of the FOXM1 genetic network in myeloma FOXM1 NEK2 CDK4 PMC8173054__F1 Endocannabinoids and Precision Medicine for Mood Disorders and Suicide NAPEPLD TRPV1 GPR119 FAAH PMC7288916__F8 H19 in regulating dopaminergic neuron loss in PD NEUROD1 PITX3 HPRT1 CTNNB1 PMC9095977__F3 Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse CXCL12 HMGB1 CXCR4 PMC4409212__F1 Novel Cancer Chemotherapy Hits by Molecular Topology: Dual Akt and Beta-Catenin Inhibitors CDC42 RHEB TSC2 BAD RICTOR TSC1 MDM2 MTOR PMC7140443__F1 Off state (left): In the absence of Sonic Hedgehog (SHH) ligand, Ptch inhibits signal transduction by SMO SUFU PTCH1 SOX2 SHH SMO MYC PMC7140443__F4 Role of SHH/Gli cascade in Ewing sarcoma development FLI1 SUFU PTCH1 SHH SMO PMC4800317__F6 Non-canonical or alternative NFKB pathway LTB CD40 LTBR RELB TRAF3 TRAF2 PMC4800317__F5 Canonical or classical NFKB pathway TRADD BCL10 TIRAP BCR IRAK1 EIF2A TRAF6 TRAF2 IRAK4 MYD88 PMC5889982__F1 Beta-arr is a potential therapeutic target for various diseases MLST8 CXCL12 EGFR GSK3B MTOR CXCR4 CTNNB1 PMC5473974__F2 The glucocorticoid receptor and nitric oxide signaling pathways ADRB2 TBP PMC6721829__F2 Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies STAT3 PTEN MTOR CCND1 PMC11652206__F2 Mechanisms by which phthalates affected sex steroids-related pathways MAPK14 DBP SRD5A2 HSD17B3 STAR CYP17A1 SCARB1 CYP11A1 BMP4 SHH MAPK10 FGF10 PMC6331208__F1 Neuroprotective effects of DBS at the synapse BAX CASP3 TFEB BDNF PMC6721829__F3 Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies STAT3 BCL2 PTEN CCND1 CTNNB1 PMC11652206__F4 Mechanisms by which phthalates affected autophagy DBP HHIP PTCH1 MTOR PMC3742248__F2 Role of miR-302 during human ESCs (hESC) neural differentiation TCF3 NR2F2 LEFTY1 SOX2 LEFTY2 NODAL PMC11652206__F3 Mechanisms by which phthalates affect epithelial-mesenchymal transition (EMT) CDH2 DBP ROCK2 SMAD2 ROCK1 SMAD4 PFN2 PMC5209621__F7 Classic mechanism for E2 action is E2 diffusing into the nucleus, binding to the nucleus estrogen receptor (ER), combining with ERE on DNA, starting transcription translation and inducing the cycle of multiplication in cancer cells BAX SP1 MTOR CCND1 PMC11652206__F7 Hypothesized macro-mechanism by which phthalates induce hypospadias STAT3 SRD5A2 VEGFA PMC8869699__F3 TLR2 in Infectious Diseases Caused by Mycobacteria: From Cell Biology to Therapeutic Target SOCS1 ATF3 TLR1 NLRX1 CD300A MHC2TA TIRAP MAL CD14 TRAF6 CYLD MYD88 PMC8699626__F2 Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective CDC2 PLK1 LATS1 MCM7 LATS2 CDK6 MCM3 CDK2 MCM5 MCM6 AJUBA NF2 MCM2 CDK4 PMC8699626__F1 Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective LATS2 FRY ZYX AJUBA HEL70 NF2 PMC7808154__F2 Interleukin‐17 and ischaemic stroke TRAF4 KY EBP TAB3 GSK3B TRAF5 TRAF3 TRAF6 TRAF2 PMC10916417__F6 Relationship between PS, PC, and PE in the glycerophospholipid metabolic pathway PTDSS2 PTDSS1 PC PCYT2 PHOSPHO1 PISD PMC8693975__F1 Modeling and analysis of the macronutrient signaling network in budding yeast ELF2 EIF2A PMC9354686__F6 Oncogenic Role of miR-217 During Clear Cell Renal Carcinoma Progression WNK2 IGF2BP2 IGF2 PMC9670321__F2 GNAQ mutations drive port wine birthmark-associated Sturge-Weber syndrome: A review of pathobiology, therapies, and current models TRIO AMOT RHO MTOR PMC9104338__F9 In Vitro Effects of Papaverine on Cell Migration and Vascular Endothelial Growth Factor in Cancer Cell Lines HMGB1 PDE10A BCL2 PTEN MTOR PMC8548662__F3 Roles of Exosomes as Future Therapeutic Agents and Diagnostic Tools for Glioma SOX2 NOTCH1 PMC4167215__F1 The mitochondrial unfolded protein response in mammalian physiology LONP1 UBL5 EIF2A PMC3157194__F4 Interaction between MAPK signaling pathway–related genes and miRNAs NTF3 EGFR NLK KRAS FOS PMC4039991__F1 Upregulation of a Steroid Synthesis Pathway in Th2 Cells In Vitro(A) Schematic representation of integrated steroid biosynthesis pathway with abbreviated metabolites (black) and protein factors (blue) CYP17A1 STAR EBP SQLE SC5D DHCR24 STARD4 MVK HMGCS1 HMGCR CYP11A1 PMVK LDLR PBR MVD DHCR7 FDPS FDFT1 TBP HSD17B7 TM7SF2 PMC5559108__F3 Subtyping Chronic Obstructive Pulmonary Disease Using Peripheral Blood Proteomics EGF TGFB1 CCL11 MMP10 NGFR CXCL1 NRP2 MMP9 VEGFA HEL-S-78p KITLG MPO NGF NTF4 NTF3 BCAN FGA PMC5675652__F6 Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds KLF4 LEP CD36 SCD EGR2 TRIB3 PMC6231613__F3 Novel protein signatures suggest progression to muscular invasiveness in bladder cancer CNOT11 ELMO3 SLC38A1 FADS2 MTOR XBP1 SLC26A2 KIF23 PRR9 CST5 ELF4 RICTOR POLG PMC4084821__F3 Irinotecan Pathway, view of a model human liver cell showing blood, bile, and intestinal compartments, indicating tissue-specific involvement of genes in the irinotecan pathway UGT1A1 UGT1A9 ABCC1 CES2 CES1 APC SLCO1B1 ABCG2 BCHE CYP3A4 ABCC2 ABCB1 PMC5623821__F9 Self‐sustaining cancer cells in 3D HGF TYRO3 AXL EGFR PROS1 MTOR SRC MERTK PMC8267694__F1 Enigmatic Role of TP53 in Germ Cell Tumours: Are We Missing Something? BAX BAD FAS BCL2 MDM2 PMC9693344__F3 Anticarcinogenic Effects of Isothiocyanates on Hepatocellular Carcinoma BAX FADD PMC9693344__F2 Anticarcinogenic Effects of Isothiocyanates on Hepatocellular Carcinoma RBX1 KEAP1 NQO1 PMC9832176__F2 TGFB signaling in the placenta via miR-574–5p mediated SMAD2/4 regulation SMAD2 SMAD4 PMC8390275__F5 Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population SIRT3 BNIP3 PMC3519901__F7 Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection GYPB IFNE JUN IRF9 TANK RIPK1 IRF3 FADD PMC11799081__F1 Apoptosis and Necroptosis GSDMD RIPK1 FADD PMC8186445__F2 Astrocytes in the Neurorepair Process NEUROD1 APC PITX3 GSK3B CTNNB1 PMC8912934__F3 Tinker, Tailor, Tumour Suppressor: The Many Functions of PRP4K EGFR PTEN MTOR PMC6876279__F1 The JAK-Stat signalling pathway IFNG EPO TPO PMC11668132__F1 Quercetin on cancer cell growth and proliferation EGFR APC ATM PMC5817811__F2 HGF/c-MET signaling pathway STAT3 HGF GRB2 MTOR RAC1 PMC11220218__F1 Metabolic reprogramming in thyroid cancer and therapeutic resistance CIC SHMT1 BRAF MTOR PMC11668132__F2 Quercetin on cancer cellular biomolecules and functions BAX BAD ATM MTOR RAC1 PMC11058799__F7 Gene network crosstalk between selected DEGs (TYK2, STAT1 and TLR7) created with NetworkAnalyst software [44] STAT1 IFIT3 IFI27 TLR7 JAK1 OAS2 TYK2 PMC5420131__F1 Canonical Wnt/Beta-catenin pathway: “WNT ON state”: WNT proteins, by binding to frizzled receptors and the LRP co-receptor, act to suppress the activity of glycogen synthase kinase-3B (GSK-3B) GSK3B ZNRF3 TEF CTNNB1 PMC4245912__F2 The secretory pathways used by NMDARs KIF17 CASK KIF1A PMC9682745__F3 Innate immunity, cytokine storm, and inflammatory cell death in COVID-19 STAT1 ZBP1 IRF1 RIPK1 TNF PMC8036620__F4 Apoptotic pathways involved in CIAKI TRADD ATF4 FADD PMC9510148__F2 Contribution of altered neuronal autophagy to neurodegeneration ATG101 ULK1 MTOR ULK2 PMC5429338__F2 Main potential molecular mechanism of the antitumour effect of anthocyanins in vitro STAT3 EGF PCNA MMP2 MMP9 SRC PMC3633842__F6 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns CRAT INSR ELF2 GRB2 EIF2A ELF3 PMC3633842__F5 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns GBP3 ADAR STAT2 IFIT1 IFIT3 IFIH1 IFIT2 IRF7 RSAD2 OAS3 STAT1 OASL MX1 TNFSF10 OAS2 PMC3633842__F4 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns STAT1 STAT2 PSMB8 IRF9 IFIT1 IFIT3 MX1 JAK1 OAS1 TYK2 PMC5420131__F3 Immune exclusion through Wnt/beta-catenin pathway: Activation of Wnt/beta-catenin pathway in tumor leads to noninflammatory milieu through multiple mechanisms ATF3 CCL4 FOXP3 IL1B CTNNB1 PMC3633842__F2 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns STAT2 TANK IFNA4 ISG15 PMC5420131__F2 Therapeutic targets in Wnt/Beta-catenin pathway and developmental therapeutics PORCN TEF CTNNB1 PMC5070917__F1 Bruton’s tyrosine kinase in autoimmunity and implications for therapy SYK BTK PLCG2 BLNK LYN PMC8154153__F6 Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells TMF1 SCFD1 COPG1 ZFPL1 RAB32 ARF3 HEL103 STX17 PACS1 PMC3946959__F1 Proposed signaling pathway for PCB detoxification in vivo PRX AHR CYP1A1 HEL-75 PMC5027289__F7 PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development SF1 CYP11B2 SHH MC2R WNT4 PMC8802865__F10 Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics TBK1 CGAS IRF3 PMC3364135__F1 EpCAM and its potential role in tumor-initiating cells CLDN7 EPCAM APC SOX2 FHL2 MYC LEF1 CTNNB1 PMC11900955__F2 TBK1 in key mechanisms of inflammation-associated diseases TBK1 PMC4815185__F7 Visualization of all differentially expressed proteins mapped to the TCA cycle pathway in the development of RAW 264.7 cells into osteoclasts in low serum culture system ACO2 IDH3B CS PDK3 PDK2 SDHD PDHX SDHA SDHB PDHA1 PDK4 SUCLA2 OGDH HEL-S-32 PDHA2 MDH2 PMC9386326__F8 Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFB signalling pathway UGDH KEAP1 PTBP3 TGFBR1 PMC11900955__F1 Different immune cells by TBK1 TBK1 CGAS IRF3 CCL5 PMC6109055__F6 Model: SIRT6 levels regulate resistance or sensitivity to MAPKi TF IGFBP2 IGF1R SIRT6 PMC8738926__F4 Starvation-induced negative energy balance on endoplasmic reticulum stress in the liver of cows ACOX1 NR1C1 XBP1 PMC9502833__F2 Prospects and Challenges of Electrospun Cell and Drug Delivery Vehicles to Correct Urethral Stricture TF APC LRP5 LRP6 CTNNB1 PMC6040832__F2 Progranulin, lysosomal regulation and neurodegenerative disease C1QA HEL-S-62p TFEB PMC3131688__F1 Autophagy in immunity and inflammation CD40 STAT3 NBR1 HMGB1 CXCL12 ATG16L1 LIF VMP1 IL4 CD46 MTOR MYD88 CLCF1 ATG3 NOD2 BCL2 ATF1 NOD1 DAP PMC4909416__F1 The CDC20-APC/SOX2 pathway in human GSCs CDC20 APC SOX2 PMC7823972__F2 MSC-exosomes are capable of protecting against radiation-induced damage to hematopoietic and nonhematopoietic systems EGF MSC PMC7957490__F1 Crosstalk between MSCs and immune cells in the initial phase of tissue injury CXCL12 CCL3 MSC CXCL2 CCL5 MIF CCL2 PMC7116639__F5 Regulatory R-loops as effectors of gene expression and genome stability RAD52 ATR RAD51 DDX1 BRCA1 BRCA2 PALB2 PMC7059126__F1 Illuminating insights into opsin 3 function in the skin MC1R TRPA1 PC PMC12043700__F4 Main regulatory mechanism of irisin in osteoclasts OSCAR NFATC1 PMC12043700__F3 The improvement of osteoblast activity by irisin SOST PTHLH HEL-S-133P ATF4 MTOR RUNX2 CTNNB1 PMC12043700__F6 Regulatory functions of irisin in osteoarthritis relief through modulation of chondrocyte metabolism TFAM SIRT3 IL1R1 NLRP3 MFN1 UCP1 PMC9490861__F3 Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments TLR1 TLR4 MYD88 PMC9592761__F3 Neuroinflammation of microglia polarization in intracerebral hemorrhage and its potential targets for intervention ACHE PPARG ITGB8 GSK3B MTOR ATG5 PMC5602294__F1 Biosynthetic pathway of NAD+ production starting from Na NAPRT NMNAT1 NADSYN1 NMNAT3 PMC12043700__F2 Irisin in the regulation of MSC proliferation and differentiation BMPR2 SMAD9 SMAD1 DKFZp781O1323 FABP4 MTOR RUNX2 COL2A1 CTNNB1 ACAN CEBPA SOST ATG12 SOX9 BMP2 ATG5 PMC4769825__F2 Schematic illustration of pathways associated with Nrf2 signal KEAP1 MAF PMC6737584__F3 Phosphorylation of central carbon metabolic enzymes HEL-S-162eP PDC SDHC PMC7890031__F2 IL-17A on osteoblasts STAT3 BMP2 RUNX2 IL1B PMC7890031__F1 IL-17A on osteoclasts NOS2 TRAF3 TNF PMC6276815__F3 Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience TF GATA2 TH REST NEUROD1 GSK3B SOX2 FEV INS LHX6 FOXG1 LMX1B DLX1 ISL1 ALK ASCL1 MYT1L PITX3 DLX2 LHX3 FOXA2 DLX5 PMC10298151__F7 Diagram showing the mechanisms involved in D2R Beta-arrestin-dependent pathway-mediated ERK activation ADRBK1 MDM2 SRC PMC9060145__F4 Preclinical assessment of dual CYP26[A1/B1] inhibitor, DX308, as an improved treatment for keratinization disorders UCP2 PLEK HEL113 PROC PMC9434538__F2 JMJD family proteins in cancer and inflammation JMJD6 ME2 IRF4 ME1 PMC10040548__F6 Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis PHGDH MTR PSPH PMC10040548__F5 Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis HEL-S-90n PHGDH MAL NAMPT CIT PMC5508010__F5 To Eat and to Be Eaten: Mutual Metabolic Adaptations of Immune Cells and Intracellular Bacterial Pathogens upon Infection PTEN TIGAR MYC PMC8295685__F1 Sonic Hedgehog Pathway in the Development of the Central Nervous System and Aging-Related Neurodegenerative Diseases KIF7 SUFU PTCH1 SHH SMO GLI3 PMC3060380__F1 Myostatin activity and muscle growth ACVR2B BMP1 TLL1 SMAD2 SMAD4 TLL2 PMC2857179__F1 Mechanisms and pathways targeted by mutations in MPN MPL TET2 CBL NF1 EPOR EPO TPO GRB2 PMC7109607__F3 SOX2-expressing tumor cells as potential therapeutic targets APC SOX2 SHH PMC8351602__F1 Intrinsic and extrinsic apoptotic signaling pathways BAX FADD PMC3868569__F1 TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans PMC3154417__F2 mTOR signaling pathway RHEB TSC2 TSC1 PTEN RHO MTOR PMC9489775__F5 Selected transcripts of developmental signaling pathway genes implicated in dorsoventral and/or anteroposterior patterning containing two or more RNA editing sites detected at their 3′-UTR region ABI2 FZD5 ACVR2B RNF146 ABL2 HEL-S-28 DUSP4 DVL2 RNF170 FERMT2 LIG1 PAF1 LLGL1 JAK1 SDC2 OCRL KCTD10 PMC4110478__F1 Hypoxia inducible factor and VEGF link the HIF/VHL and PI3K/Akt/mTOR signaling pathways ADM HEL-S-133P EPO PTEN VHL PMC7347234__F7 System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion PC DHODH PMC5508010__F4 Quiescent (A) and activated (B) metabolism in differentiated mammalian cells RPE OGDH F2 MAL KIT CIT PMC2937518__F4 Overview of predicted carbohydrate uptake and metabolism systems in bifidobacteria GAL PTS MIP FOS PMC5508010__F2 Schematic presentation of the basic catabolic and anabolic processes of a typical heterotrophic prokaryotic cell: glycolytic pathway (GL), pentose-phosphate pathway (PPP) with its oxidative and non-oxidative arms, and tricarboxylic acid cycle (TCA) HEL107 RPE OGDH MAL CS CIT PMC8384663__F1 Multifactorial pathogenesis of psoriatic disease POR KLK6 CARD14 RUNX1 FUT8 TNFAIP3 STAT4 TNF CCL20 IL23R TYK2 IL12RB1 PMC9459018__F4 Metabolome and RNA-seq Analysis of Responses to Nitrogen Deprivation and Resupply in Tea Plant (Camellia sinensis) Roots POR ASL MAL PMC9609565__F7 Morinda officinalis Polysaccharides Ameliorates Bone Growth by Attenuating Oxidative Stress and Regulating the Gut Microbiota in Thiram-Induced Tibial Dyschondroplasia Chickens BMP2 RUNX2 GPX1 PMC11959002__F2 ncRNAs promote PCa metastasis through the PAM signaling pathway PCDH9 CDC6 EGFR CUL4B EZH2 PTEN CCL20 PMC7159845__F3 Cellular model of insulin and leptin signaling in Kiss1ARH neurons KISS1 TRPC5 PMC9459018__F6 Metabolome and RNA-seq Analysis of Responses to Nitrogen Deprivation and Resupply in Tea Plant (Camellia sinensis) Roots LOX ADK ALLC PC KIT GDA PMC11959002__F1 ncRNAs inhibit PCa metastasis through the PAM signaling pathway ERBB3 LAPTM4B CUL4B NEK2 ERBB2 ZNF217 PTEN GAB2 PMC3585121__F6 Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci LAT PRL GC PMC7147028__F8 Schematic diagram showing potential involvement of miR-761 inhibiting EMT in CRS mice through targeting LCN2 in the LCN2/Twist1 signaling pathway CDH2 LCN2 TWIST1 PMC11959002__F4 ncRNAs inhibit PCa growth through the PAM signaling pathway KLF4 EN2 CUL4B KIDINS220 PTEN PMC11959002__F3 ncRNAs promote PCa growth through the PAM signaling pathway EGFR EZH2 PTEN CCL20 PMC11959002__F6 ncRNAs regulate PCa tumor stemness through the PAM signaling pathway BMI1 KLF4 EGFR FGFR1 SOX2 IGF1R PMC11959002__F5 ncRNAs regulate PCa angiogenesis through the PAM signaling pathway RICTOR KIDINS220 MTOR PMC8190037__F3 Analysis of the role of PurA in the pathogenesis of Alzheimer's disease based on RNA-seq and ChIP-seq LPL IDE CASP9 BAD CASP12 APOE GSK3B CASP3 SNCA TNF APAF1 FADD PMC3462655__F2 The signaling pathways involved in T-cell activation LTK LAT CSK ARHA LCK PMC5427104__F1 Activation and evasion of lectin pathway (LP) of complement HEL-S-62p C2 C4B_2 PMC11508835__F4 Amino acid pathway interaction with mTORC1 SLC3A2 FNIP2 LAMTOR5 FLCN SLC7A5 CASTOR2 SESN2 CASTOR1 SKP2 RNF152 SLC38A9 PMC4310328__F1 Schematic figure of the complement system CRP C6 CD59 C7 MASP2 HEL-S-62p C2 C9 CR1 CP PMC11508835__F3 AMPK signaling pathway RHEB TSC2 TSC1 TBC1D7 STRADB PMC6599710__F2 Genomic correlates of response to immune checkpoint blockade SOCS1 STAT1 IFNGR2 IFNGR1 MEX3B IRF1 B2M JAK1 PMC9578007__F5 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis IL15 FNDC5 METRNL GDF8 LEP EGFR SPARC NAMPT IL6 RARRES2 TNF TNR RETN GUGU FST HSD17B13 AHNAK BDNF SELENOP TNLG7C PMC11508835__F2 Insulin/PI3K/AKT signaling interactions with mTOR MAPK1 RAF1 SOS1 GSK3B PTEN IRS1 RHEB HRAS TSC2 TSC1 GRB10 IGF1 PDPK1 CHUK TBC1D7 MAP2K1 GRB2 PMC9578007__F4 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis PPARG NR1C1 SHBG FASN LECT2 FACL4 PPARGC1A TNF PMC11508835__F1 mTOR signaling pathway DVL1 LRP5 LRP6 PTEN STRADB CASTOR1 SKP2 DEPTOR IRS1 RHEB TSC2 TSC1 GRB10 IKBKB CASTOR2 SESN2 RNF152 PMC9578007__F3 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis PPARG SLC2A4 EGFR TNF INS UCP2 AHSG CDKN2A NR1C1 FST TLR4 PPARGC1A HEL-S-44 PMC9578007__F2 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis PPARG IL10 SLC2A14 SLC2A4 EGFR FASN RBP4 SMEK1 FABP4 IL17A TNF NR1C1 TLR4 DPP4 LIPE PPARGC1A MAP3K5 PMC8525330__F3 CREB1 coordinates transcriptional networks in DCs and CD4+ T cells which drive key immune effector functions TBX2 PPARG TAPBP APPL1 FLT3LG PIN1 SIN3B HAX1 TYROBP E2F4 CLTA NPTN CCR7 HEL-S-11 CYBA CREB1 CPEB3 TNFRSF14 MAPKAPK2 MIF PTK2B CXCL10 SPN LTB BRWD1 tal-1 TTF2 CDKN1A Nbla10317 MAP3K5 TBK1 MAFK CNOT4 PML ASH2L RORA ELF4 HLA-G IL18 UBE2D3 CHUK TLR7 NOD1 MAP2K3 NUCKS1 DOCK8 UBQLN1 MCOLN2 ARHA KRAS CD47 TNLG2B RHOU CUEDC2 IL24 SYNC CREBBP CD200 FOXA2 AP1B1 PMC5889818__F3 Schematic overview of three different modes of cell death: apoptosis, necrosis and necroptosis RIPK3 TRADD MLKL RIPK1 TNF FADD PMC3745930__F5 Roles of hnRNPs in the impaired granulocytic differentiation of BCR/ABL transformed myeloid progenitor cells FUS BCR EBP PMC3577828__F6 Jejunal Proteins Secreted by db/db Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance RHEB TSC2 TSC1 IRS1 PMC4863733__F2 Birth of a Carcinoma-associated fibroblasts PDPN FOXF1 CD36 PDGFRA SPARC SHH CXCL2 FAP PMC4267804__F6 RNA-Seq Analysis of Equine Conceptus Transcripts during Embryo Fixation and Capsule Disappearance CASP9 BAD PLG SRC PMC10526236__F4 MicroRNAs in the Regulation of RIG-I-like Receptor Signaling Pathway: Possible Strategy for Viral Infection and Cancer MAVS TRIM25 RNF123 IRF3 IRF7 TRAF6 PMC5838471__F1 Metabolic pathway of AB and GPCRs in Alzheimer's disease BAD CDK5 GSK3A APP ChAT GPR3 IL8RB PMC11506742__F1 TLR/IL-1R signaling pathway STAT3 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC11506742__F2 IRAK1 in the metastatic cascade CDH2 CDC2 IL10 CDC45 CXCL1 IRAK1 VCAM1 CCL5 MCM2 TNF CCL20 PMC7432832__F1 Aryl hydrocarbon receptor (AhR) pathway AHR AHRR PMC7432832__F3 AhR pathway interactions in cancer breast cells TH AHR IL6 MYC PMC6280631__F2 The melanogenesis pathway shows where common ENAMs affect the pathway MC1R BRAF TYRP1 ENAM PMC2537559__F5 Alterations in adhesion-mediated signaling and cytoskeleton remodeling in metastatic cancer TRIO PLAUR EIF4H HEL-S-28 PTEN VAV1 VEGFA ARHA DOCK1 EIF4E HRAS CRB2 PLAT PMC2537559__F4 Alterations in extraceullular matrix and secreted proteins associated with metastatic cancer CD44 MMP16 EGF TIMP3 PLAT SERPINE2 IGF1 MMP10 EGFR PLAUR PLG IGF2 PMC2537559__F3 Glycolysis pathway PGAM1 PGAM2 ENO2 ENO3 HEL-S-133P LDHB ENO1 CS PMC4995061__F1 Plasticity of Arterial and Venous Endothelial Cell Identity – Some Nerve! EPHB4 EFNB2 NRP1 PMC6892980__F2 Macrophage exposure to Magnéli phases activates gene expression profiles associated with apoptosis and mitochondria dysfunction BAX BCL2L1 TNFRSF1A MCL1 BCL2 TNF ATG5 CYLD APAF1 PMC4910072__F2 Respiratory metabolism and calorie restriction relieve persistent endoplasmic reticulum stress induced by calcium shortage in yeast ENG CENPK SCD HK2 TEF PMC7322824__F1 STRING connectivity network analysis identified protein–protein interactions between CUL2, EGLN1, RBX1, LDHA, TFRC, and PFKL EGLN1 RBX1 HEL-S-133P PFKL MAP2K2 PMC8945049__F4 Differential Transcriptome Profiling Unveils Novel Deregulated Gene Signatures Involved in Pathogenesis of Alzheimer’s Disease CDC42 OGT GRIA3 DDR1 UBE2G2 GAP43 DNCL1 CAB39 PXN RNF7 GABRB2 THBS3 POLR2K KCNJ4 ATP2A2 NCK2 MYLK3 PRKCB MAPK14 GDI1 SYP TPM3 HEL-S-32 AGA YWHAG AP2S1 APC RPH3A SNCA LDHB MTO1 POLR3H BRK1 SDHB TAF1 KDM1A UBE2H HAP1 AVIL CALM1 HEL110 RGS4 POU2F1 EP300 ITGB5 SDHC MCHR1 PS1TP5BP1 PMC11033503__F1 C/EBPB regulates signaling pathways associated with brain inflammation in AD HEL-S-62p CD200R1 BDKRB2 PMC4023866__F1 Bacterial effectors that target and manipulate the innate immune and inflammatory pathways MAP3K7IP1 TLR4 CD14 CLPX TRAF6 PMC11851453__F1 Two-end black (TEB) coat color phenotype, schematic diagram of EDNRB transcripts and their encoded protein, three-dimensional structure prediction of the EDNRB protein, and an EDNRB melanin pathway diagram EDN1 EDNRB PMC11033503__F2 C/EBPB: A transcription factor associated with the irreversible progression of Alzheimer's disease GSK3B SRPK2 APP BDNF SET PMC11033503__F4 C/EBPB: A transcription factor associated with the irreversible progression of Alzheimer's disease ORAI1 STIM1 TRPC1 PMC4300719__F6 Pathway analysis in groups A (A) and B (B) CASP9 BAD RASSF1 RARB ERBB2 FHIT DAO GAB2 PMC6057902__F2 Extended, context‐specific melatonin receptor signalling pathways BAX SIRT3 FOXO1 BCL2 SIRT1 PMC2934775__F9 Fluxmap of the glycolysis, penthose phosphate pathway, and citric acid cycle for the experiment where nitrogen-limiting medium is changed to carbon-limiting medium at time zero MAL PTS CIT PMC2934775__F8 Fluxmap of the glycolysis, penthose phosphate pathway, and citric acid cycle for the experiment where carbon-limiting medium is changed to nitrogen-limiting medium at time zero MAL PTS CIT PMC8530873__F1A Stress stimulus produces a physiological response which involves the central nervous system (CNS) and the periphery ATR SIK1 EGR1 RAD51 BRCA1 SIK3 SIK2 ATM CDKN2B PMC3038194__F1 Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancer NRG2 EGF NRG1 HBEGF JUN BAD TGFA EGFR NRG3 GRB2 MTOR FOS PMC2515336__F2 Representation of the two NFKB signaling pathways LTB CD40 RELA RELB PMC2709856__F1 It’s all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection MAP3K7IP1 TIRAP TLR4 MAL IRF3 TRAF3 TRAF6 MYD88 PMC5859251__F6 TRIM29 regulating anti-DNA virus immune response through targeting STING TBK1 CGAS DDX41 IRF3 TRIM29 PMC2707763__F6 PROK1 induction of RCAN1-4 and IL-8 CA3 PROK1 C2 RCAN1 PROKR1 RCAN3 PMC2268661__F2 The diagram of GSH redox cycle GPX4 GCLM GCLC HEL-S-64p PMC8245224__F9 Loss of Function of von Hippel-Lindau Trigger Lipocalin 2-Dependent Inflammatory Responses in Cultured and Primary Renal Tubular Cells HK2 LCN2 VHL PMC6366148__F3 PI3K/Akt/mTOR pathway activated by IL-2 and CD28 signaling and growth factors IL7R MTOR PMC5833125__F2 Signaling networks in osteoclastogenesis SYK VAV3 OSCAR BLNK NFATC1 TRAF6 TREM2 TEC BTK MAP3K7IP1 GRB2 TRAF2 GAB2 PMC7520308__F1 Biosynthetic pathway of tetrahydrobiopterin: de novo pathway from GTP and two other salvage pathways from sepiapterin and 1′‐hydroxy‐2′‐oxopropyl‐tetrahydropterin, respectively SPR DHFR PMC2875112__F1A Targeting Multiple Kinase Pathways. A Change In Paradigm BAD GSK3B PTEN MDM2 PMC8394096__F1 Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review BAX BAD PAK1 PTEN MDM2 PMC10750291__F4 Biological mechanism and emerging therapeutic interventions of liver aging MAX TRADD ATF2 NLK PMC3146512__F2 Genome Sequence of a Mesophilic Hydrogenotrophic Methanogen Methanocella paludicola, the First Cultivated Representative of the Order Methanocellales POR CP PMC10750291__F6 Biological mechanism and emerging therapeutic interventions of liver aging TH TICRR MAU2 TRADD CDC20 PCNA CDC6 SMC3 SMAD2 ESCO1 SMAD4 MYC SKP2 CDK6 CDK7 E2F4 WAPAL MDM2 CDK4 CDC2 DBF4 TRIP13 S100A7 APC KNTC2 ESCO2 RAD21 MTBP tal-1 DDX11 CDK2 LCN2 S100A9 FADD PMC1681468__F6 Combinations of multiple states of complexes ERBB3 NRG2 NRG1 PMC10750291__F5 Biological mechanism and emerging therapeutic interventions of liver aging CD40 CD80 CAD TIRAP AIP CTSK TLR9 CD14 IRF3 TRAF3 TRAF6 IRAK4 MYD88 PDC ATF4 LBP FADD PMC1681468__F5 Ellipsis in drawing association states of proteins using an 'address' EGF EGFR GRB2 SHE PMC4140976__F2 Tissue-specific Insulin Signaling in the Regulation of Metabolism and Aging IGF1 IGF1R IRS1 PMC4140976__F1 Tissue-specific Insulin Signaling in the Regulation of Metabolism and Aging RHEB TSC2 BAD GRB10 TSC1 APPL1 ULK1 GRB2 MTOR PMC7366241__F1 Non-coding RNA in GC NKD1 LIN28B UFC1 HMGA2 GC PTEN CTNNB1 PMC8465902__F5 Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer TF MFN2 FES PMC8465902__F4 Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer CISD2 NUBP1 CIAPIN1 CISD1 MMS19 ABCB7 CIAO1 CIAO2B CIAO3 NDOR1 NDP PMC1992519__F2 Signaling on the endocytic pathway EGF EGFR SMAD2 EEA1 PMC6941297__F1 Protein expression, molecular pahtways, facilitators and mutations involved in the genesis of brain metastases from melanoma, breast and lung cancer BNC1 CXCL12 GALNT9 KEAP1 EGFR GAD1 BRAF CTSS RHO MTOR CXCR4 TOP2A PMC4186342__F1 Trafficking of TLR4 RAB10 RAB7B TMED7 RAB11A TLR4 CD14 PMC5839936__F2 Proteins significantly altered by torcetrapib associated with aldosterone synthesis or function VIP BMP6 DKK3 TGFB1 PYY POMC ANGPT2 NPPB PMC10779133__F2 Neuroprotective effects of KBs and KD by providing energy source and improving mitochondrial dysfunction in the brain SIRT3 FOXO1 SIRT2 SIRT1 PMC10779133__F1 Ketogenic and ketolytic pathways in the liver and brain cells ACAT1 HMGCL BDH1 CS PMC10779133__F4 Signaling functions of KBs and KD for anti-neuroinflammation and autophagic flux HCAR2 STAT3 LAMP2 NR1C1 NLRP3 COX1 FOXO1 ULK1 FOXO3A TFEB RHO PMC5839936__F3 Proteins significantly altered by torcetrapib associated with insulin sensitivity or pancreatic Beta-cell function FSTL3 TGFB1 GSK3A PRKCQ CD36 APOE MMP2 MAPK8 GHR TWEAK PMC10779133__F3 Signaling functions of KBs and KD for anti-apoptosis, antioxidant defense, and epigenetic and post-translational modifications UCP2 FOXO1 BDNF NOX4 PMC4286324__F3 Schematic diagram describing Src regulation by trafficking RHOB SRC EHD1 PMC11846620__F6 Molecular Mechanisms of Immunoinflammatory Infiltration and Ferroptosis in Arthritis Revealed by a Combination of Bioinformatics and Single-Cell Analysis TF SLC3A2 GPX4 LPCAT3 FACL4 SLC7A11 FTMT PCBP1 STEAP3 F2 ATG5 HEL-S-64p CP PMC2615463__F1 Arc function in mGluR-LTD EEF2K EEF2 ARC PMC3049852__F1 Multifunctional effects of CMKLR1 activation SYK CMKLR1 MTOR SRC PMC8929637__F2 An illustration of the known proteins involved in glycerolipid synthesis in Apicomplexa parasites LPA ELOA FAS ELOC PMC6292430__F2 Does Axl have potential as a therapeutic target in pancreatic cancer? STAT1 AXL EGFR PMC10037252__F2 Systemic treatment for metastatic colorectal cancer EGFR MTOR IRS1 PMC2676302__F5 Major trends in mRNA expression at 56 days on experimental diets and summary network analysis among genes ACLY PPARG LPIN2 SCD FASN NR1C2 FADS2 FABP4 ACACA PRKAA1 SLC27A1 GPAM THRSP PMC9138678__F1 Brain-Derived Neurotropic Factor in Neurodegenerative Disorders EGF MTOR SRC BDNF MYD88 PMC8230033__F1 Altered Bone Status in Rett Syndrome LRP4 SFRP4 LRP5 LRP6 HEL-S-11 RUNX2 CTNNB1 PMC4376959__F2 Sphingolipid metabolism CERS3 CERS5 CERK SPHK2 CERS1 CERS2 SPHK1 CERS6 PMC2817888__F3 ATM/ATR DNA damage response pathway and its downstream effectors leading to either G1/S or G2/M phase arrest ATR CDK2 ATM PMC4286324__F1 Membrane dynamics and the endocytic pathway EHD3 RILP EHD1 PMC4484234__F1 Structures of schweinfurthin B and 3-deoxyschweinfurthin B (3dSB) IPP RAP1A FDPS PMC9793423__F1 Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights CNTF OSM CRH LIF CLC PMC4888213__F3 Multiple somatic alterations in components within the same pathways FAT4 APC INPP5D PTEN MTOR RB1 CDKN2A MAP2K4 DKK1 AXIN1 ERBB2 ATM DKK2 CCND1 PMC3262546__F1 The p14-p53-p21 and p16-Rb signaling pathways involved in fibroblast senescence CDK2 MDM2 CDK4 PMC9793423__F5 Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights STAT3 LIF MMP2 MDM2 CCND1 ID1 CTNNB1 GATA3 PMC2778684__F1 Canonical and non-canonical Wnt signaling pathways ROCK2 APC LRP5 ARHA DAAM1 PMC2915874__F4 Effect of estrogen on endothelium-dependent pathways of vascular relaxation COX1 GC SRC PMC2915874__F3 ER-activated postreceptor mechanisms HBEGF EGFR SRC PMC3516599__F1 Proposed Multicompartmental Degradative Pathway of L-lysineL-Lysine degradation is initiated by either peroxisomal Alpha-deamination (pipecolate pathway) or mitochondrial E-deamination (saccharopine pathway) GCDH DHTKD1 PIPOX AASDH AADAT AASS PMC7518784__F2 Inflammatory induction of the colorectal cancer (CRC) occurrence STAT3 IF2B1 CXCR1 BRAF IL17A IL8RB KRAS PMC5682390__F1 Metabolic pathways for engineering oleaginous yeasts to produce a variety of different compounds FAS LOX CAD FADD PMC4281941__F10 miR-93-directed down-regulation of DAB2 defines a novel oncogenic pathway in lung cancer LATS2 TP53INP1 CDKN1A ITGB8 F3 SP7 PTEN VEGFA BCL2L11 AID PMC2575183__F7 Proposed signaling mechanism that stimulates EMT GSK3B HEL-S-28 LEF1 CTNNB1 PMC10558021__F2 Cyclophosphamide metabolic pathway CYP2B6 CYP2C19 CYP2C9 CYP3A4 PMC10095465__F1 Apoptotic signaling pathway BAX BAD FAS TRADD MCL1 BMF TNF HRK FADD PMC3093880__F8 miR-122 and liver-related functions and diseases MMP7 ARHGAP1 CLIC4 HEL113 SLC7A1 FUT8 PXN MAP1B MAP4 PTPN1 CS SLC4A3 FOSL2 CDA GNPDA1 GYS1 BCAT2 HEL-S-87p VPS4A PMC9563233__F1 ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway H2AX CHEK2 ATM PAX6 PMC8807479__F4 Functions and Regulation of Translation Elongation Factors DPH1 DPH2 DPH6 DPH7 FES DPH3 DPH5 EEF2 PMC3093880__F9 Associations among miR-122-identified targets MMP7 ARHGAP1 JUN HEL113 PNN VAMP2 PXN VAMP3 METAP2 PTPN1 PAK4 SLC2A3 MIF TRIP6 RAC1 MYLK FOSL2 CDA FOSL1 MAP2K1 CEBPB CREB1 SMARCA4 PMC6822533__F1 Engineering anti-cancer nanovaccine based on antigen cross-presentation SEC22B RAB11A FER PMC6207917__F6 Mechanism of DQP on cardiac lipid and glucose metabolism GSK3B ACADL CPT1A PMC6053540__F4 Biogenesis of miR-451 AGO2 GC DROSHA PMC5993488__F2B Cumulative HLA class I and APM defects across gliomas from TCGA TAPBP MHC2TA IRF1 TAP2 PMC3836075__F5 The role of Ang II and its metabolites in the adrenal gland vasculature PRCP ACE2 PMC9325158__F1 Activation of Stimulation of Interferon Genes (STING) Signal and Cancer Immunotherapy TH CGAS IFNAR2 IRF9 IFNAR1 RELB IRF3 TRAF6 PMC10142234__F1 Graphical representation of JAK-STAT signaling pathway and therapeutic compounds suppressing it through the inhibition of one or several members of the family JAK3 JAK1 TYK2 PMC2713566__F1 Mitochondrial pathways of electron flow resulting from the substrates and inhibitors used in this study MAL FES CIT PMC8905312__F1 Candida albicans stress response pathways in antifungal tolerance and resistance TPK1 PMC6262299__F2 Neurotrophic factor (NTFs) signaling pathways CNTF NGF BAD GDNF BDNF RET PMC5891588__F1 Development of NEPC by the SRRM4-mediated RNA splicing network SRRM4 FOXA1 PHF21A PMC8255319__F2 Molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives ACLY HEL-S-133P HK2 FASN GFPT1 SLC7A5 ME1 KRAS RPE HMGCR RPIA LDLR SOAT1 HEL-S-32 PMC6146607__F1 Lipogenesis and cholesterol synthesis pathways ACLY ACAT1 FAS SCD FASN ACACA ELOVL6 PMC8198029__F4 SARS-CoV-2-Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer IL15 STAT3 PPARG NFATC2 TLR9 HIF1A MTOR IKBKG IFNG STAT1 LY96 RIPK2 TLR4 EBI3 CCR7 IL18 IL2 HMGB1 NOS2 IL10 IF2B1 IL13 MNT IL4 IRF3 IL17A PTGS2 MMP9 IL1A IL6 TNF CXCL10 NR3C1 PARP1 CD44 TIGIT NR1C1 TLR1 HEL-S-125m NFKB1 RELA NFKBIA EP300 PMC8198029__F3 SARS-CoV-2-Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer HEL-S-22 KLF4 F11R STAT3 SYK NFATC2 BRAF PML HIF1A ATF2 SOCS3 RORA PRKCB CTNNB1 MYD88 TGFBR2 MYLK FOXM1 CDKN2A SOX9 MUC1 IL2 SRC CCND1 IL1B IL9 HMGB1 IL12A HEL-S-67p IL13 TRPV1 IL4 IRF1 IL17A PTGS2 VEGFA IL6 CD44 PRKCI TNFSF10 DIABLO PMC7862565__F24 Molecular signaling pathway BAX TLR4 MYC TNF FADD PMC8198029__F1 SARS-CoV-2-Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer EGF PIK3CA TGFA MAPK15 KDM3A IGFBP2 TBX21 EPCAM IFNG CDX2 EREG NR1B3 FOXC2 ICMT IL18 NOTCH1 COPS6 RPTOR MSH6 PSMD10 THBS1 DCC IF2B1 PLAUR APC EZH2 CDX1 AREG MIF KRAS RBPJ ATF3 NRG1 TCF3 KDM1A RUVBL1 ERBB2 PTGES RPS6KA3 GJA1 FGF18 PMC6335273__F4 Three main features (GSIS, beta cell mass and insulin action) and insulin secretion pathway in GK rat IDE PPP1R3E BAD SLC2A2 FAM3B CACNA1F GHSR ADCY9 ADCY3 ABCC8 NR2A2 HDAC9 GCK PMC9650235__F3 IL-7: A promising adjuvant ensuring effective T cell responses and memory in combination with cancer vaccines? BAX BAD FOXO1 MCL1 JAK3 JAK1 PMC8839962__F1 Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases PGR HEL-S-162eP RS1 MTOR INS IRS1 PMC3794211__F2 MiRNAs implicated in neurodegeneration FUS REST LRRK2 SNCA APP ADAM10 TBP HTT PMC7369905__F4 NRF2 regulates inflammation and immunity CD80 IL16 MARCO TNF PMC7369905__F3 NRF2 regulates metabolism MTHFD2 HEL107 GCLM GPT2 ENO4 SLC7A11 ME1 HEL-S-30 PCK1 FADS1 FTL F2 GCLC FBP1 ENO1 GLS2 HEL-S-26 HEL-S-64p HEL-S-44 PMC8462294__F2 Progression on the Roles and Mechanisms of Tumor-Infiltrating T Lymphocytes in Patients With Hepatocellular Carcinoma STAT3 FOXP3 CTNNB1 PMC4986688__F1A Immune mediators of chronic pelvic pain syndrome IL-21 CD40 IFNE IL10 IL13 IL4 IL6 PMC2689776__F7 Proteomics and Pathway Analysis Identifies JNK Signaling as Critical for High Linear Energy Transfer Radiation-induced Apoptosis in Non-small Lung Cancer Cells FAS IGF1R PMC4654485__F2 Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer HIF1AN AGO1 MTTP HIF1A VEGFA VHL PMC3821857__F7 DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma EGF EGFR KRAS PMC5569050__F5 Mechanism of skin dopaminergic sensory modulation DBH PIEZO2 TRPV1 PMC8149214__F5 Epidermal Growth Factor Protects Against High Glucose-Induced Podocyte Injury Possibly via Modulation of Autophagy and PI3K/AKT/mTOR Signaling Pathway Through DNA Methylation F2R MTOR PMC6522820__F2 Effect of the PI3K/AKT signaling pathway on gynecological tumors TSC2 PTEN PMC6522820__F1 The PI3K/AKT signaling pathway EGF PTEN PMC2769250__F3A Trafficking of Heme and Porphyrins in Metazoa CPOX ABCB6 UROD UROS PMC11528219__F2 Stomatal development by environmental signaling in Arabidopsis CA4 ERF ICE1 HEL-S-11 PMC8492792__F4 Multiple strategies for inhibiting Hh signal transduction pathway BRD4 SUFU SMO PMC2829367__F1 Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy CD44 GSK3B CCND1 LEF1 TWIST1 CTNNB1 PMC8492792__F3 Hh signaling in cancer GPR161 SUFU PTCH1 SMO PMC8492792__F1 Conserved Hh signal transduction pathway ADRBK1 SPOP KIF7 SUFU SMO PMC7857091__F1 Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer C6 CD59 C7 MASP2 C2 C9 VTN CPN1 CD55 CR1 PMC8616011__F3 Immunotherapy in Breast Cancer: When, How, and What Challenges? B2M CCL2 PMC7758290__F1 Complement system CD59 FH C2 C1S CLU CD46 CD55 CR1 PMC3828559__F1 RAS-RAF pathway and immunohistochemical staining of colorectal cancer specimens with BRAF V600E mutation specific monoclonal antibody EGFR BRAF KRAS PMC5260505__F6 Proposed function of CDK1 in regulating pluripotency CDC2 SMAD2 GSK3B PMC5362072__F3 Cell-intrinsic effect of STING activation in tumor cellsThe functionality of the STING signaling pathway can be altered in tumors.A) Oncolytic viruses like HPV or adenoviruses drive E7 or E1A oncoprotein expression CGAS RAE1 PMC4831676__F7 Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells EIF4EBP3 RPS6 RPS6KC1 ULK1 RPS6KA4 BNIP3 ATF4 BNIP3L MTOR EIF2A EIF4E PMC4370290__F3 Pathways involved to block cell cycle progression CDC2 ATR CDK6 CDK2 ATM CCND1 CDC25B CDK4 PMC2827616__F8 Signaling pathways controlling ENS precursor migration and lamellipodia formation CDC42 GDNF PTEN RHO GRB2 SHE RAC1 RET PMC4819324__F1 Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis IPP RAP1A FDPS PMC9441940__F1 Multiple myeloma metabolism – a treasure trove of therapeutic targets? ACSS2 PHGDH SLC1A4 PMC11985624__F2 Conceptual representation of potential mechanisms for osteogenic effects of exercise SOST MSC IL6 IMPACT PMC8093649__F6 Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases CD40 TRAF2 RAC1 PMC7313746__F4 Signature genes associated with immunological non-responsiveness to anti-retroviral therapy in HIV-1 subtype-c infection RPS15A UBC ITGA4 TIMELESS HNRNPA0 TOM7 GSK3B SATB1 RPS3A RPL39 RPS24 ITGB1 CENPK RECQL ITGA6 RPL4 MDM2 PMC11985624__F1 Osteocytic changes in sclerostin expression mediate bone mechanotransduction to skeletal loading APC GSK3B MSC CTNNB1 PMC8093649__F3 Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases SHARPIN MAP3K7IP1 TRADD MLKL TRAF2 FADD PMC7353046__F7 Adams–Oliver Syndrome and Notch signaling ARHGAP31 DLL4 DOCK6 RBPJ PMC7353046__F6 Dowling Degos Diseases and Notch signaling KRT5 PSENEN POFUT1 PMC8615798__F6 Association of Mutations Identified in Xanthinuria with the Function and Inhibition Mechanism of Xanthine Oxidoreductase MOCS1 MOCS3 GPHN MOCS2 MOCOS PMC8093260__F1 An update on the regulatory mechanisms of NLRP3 inflammasome activation BRD4 SYK MAVS CD36 TXNIP MLKL TRAF6 MYD88 CASR C5AR2 FYN NLRP3 ZBP1 S1PR2 TLR4 MFN2 RIPK1 IL1B APOC3 BAX TNF RIPK3 TRPM2 TLR3 LYN FADD PMC12123091__F4 Key metabolic pathways of proline and hydroxyproline in the cell GLUD1 CLYBL PRODH DAO PYCR2 PMC12123091__F3 Metabolic pathway of hydroxyproline as an initial product for intracellular interconversions and processes PRODH2 PRODH GPT PMC7246457__F5 Network analysis of proteins related to inflammation-driven pathology of ARPE-19 cells FAS RAF1 GLS SOS1 EGFR PIK3R1 GPX1 MAPK3 CTNNB1 POR BCL9 PLCG1 EIF2S1 HSF1 LPCAT1 SRC SMARCA4 MTAP SP1 HEL-S-133P GCLM CTH JAM3 BCL9L HMGA1 AGFG1 PRKAA2 HEL-S-102 CORO1A FADD PMC5749905__F1 mTOR signaling pathway and its upstream elements RHEB NF1 GSK3B TERT PTEN PMC4900950__F3 Signaling pathways regulating Müller glia cell dedifferentiation and proliferation following retinal injury in zebrafish STAT3 HBEGF INSM1 ASCL1 SMAD2 TGIF1 CTNNB1 PMC3982454__F8 CD44 protein-protein interaction pathways were performed by String 9.0 Web software CD44 TSC2 UBC FOXO1 GSK3B PTMS TERT PTEN MDM2 MTOR PMC2577715__F9 Nrf2 and transcriptional regulation of Gamma-GCSh expression MAFK KEAP1 PMC9524569__F2 Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway STAT3 HMGB1 NLRP3 TLR4 RELA MYD88 PMC2577715__F4 NFKB signaling and MDR gene expression CD40 RELB MYD88 PMC9695095__F2 The NLRP3 inflammasome in chronic inflammation in asthma and chronic obstructive pulmonary disease ADAR MUC5AC GSDMD TRPM2 TRPA1 NLRP3 TLR4 PIR TRPV1 AHR SIRT1 PMC3525581__F7 Toxicogenomic Analysis Suggests Chemical-Induced Sexual Dimorphism in the Expression of Metabolic Genes in Zebrafish Liver PMC6025455__F4 Endothelial targeting to boost endogenous antithrombotic and anti-inflammatory pathways APC PC PMC8842666__F6 ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability ASB17 RELA TRAF6 PMC9139376__F6 Three-Dimensional Organotypic Cultures Reshape the microRNAs Transcriptional Program in Breast Cancer Cells AURKA STAT3 DKFZp781O1323 VLDLR CAB39 MCL1 SMAD2 SMAD4 MAPK9 PSEN1 MAPK8 MAPK14 CDK5R1 TP53INP2 CDK6 OSMR E2F3 COL4A2 MMP2 COL4A1 CDKN3 PLOD2 MDM2 GK5 MAPK1 BMPR2 SP1 TFDP1 DKC1 MXD1 PERP NRARP LMNB2 NOTCH2 SATB1 PHLDA3 TSC2 PITPNC1 MAP3K1 CDKN1A CDKN1B COL27A1 CDK14 COL12A1 AKAP12 SMURF2 IL10RB NINJ1 EGF TGFA CDC6 PPP3R1 PTEN MTOR TGFBR2 MYLK CTCF IL1R1 NOLC1 CCND2 NOG ROCK1 ITPR2 GAS1 CCND1 CDK4 CDC2 COL1A2 KLF6 CUL5 SMAD6 PTPN11 DKK3 NCOR2 RBL1 HDAC1 ANKRD45 SMURF1 CDK15 SLC20A1 PFKP BMP2 SKP1 CREBBP HEL-S-87p PMC5146659__F5 Role and mechanism of the AMPK pathway in waterborne Zn exposure influencing the hepatic energy metabolism of Synechogobius hasta RHEB FAS PKD1 MTOR CCND1 PMC6186122__F3 Schematic of the extrinsic and intrinsic coagulation cascade TF TFPI F2 APC PC F11 PMC6153639__F1 Folate structure and metabolic pathway DHFR FPGS DHPS NDP PMC8534845__F1 Immunotherapy in Extensive-Stage Small Cell Lung Cancer AURKA ATR NEUROD1 EZH2 CCL5 CXCL10 MYC RB1 ASCL1 WEE1 SLFN11 ATM DLL3 PMC5435901__F3 Curcumin plays a protective role at the priming and the activation stage of renal fibrosis JUN NEDD4 SPHK1 CCR7 CTNNB1 PMC8692700__F2 Functional role of Pescadillo ribosomal biogenesis factor 1 in cancer BRD4 PES1 GSK3B PTEN TCF4 HIF1A AXIN2 CTNNB1 PMC2413058__F7 Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor CBL EGFR PMC6952538__F3 Intermediates of the cholesterol biosynthetic pathway function as RORGagonists CYP51A1 EBP SQLE SC5D DHCR24 HMGCS1 ACAT1 HMGCR CYP7A1 CH25H CYP46A1 DHCR7 FDFT1 HSD17B7 TM7SF2 PMC3781481__F2 Classic and alternative lipogenic pathways of fructose KHK TG FAS ACO2 AMPD2 PMC1601944__F1 HIF-dependent VHL pathways in oncogenesis TGFA EGFR EPO VHL PMC6588196__F1 Possible sex effects on aspects of the CR/Met R mechanistic pathways IGF1 FGF21 MTOR PMC7934455__AF1 lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/Beta-Catenin Pathway and Oncogenic Autophagy CUL4A ATG12 CTNNB1 PMC9410805__F7 Proanthocyanidins Activate Nrf2/ARE Signaling Pathway in Intestinal Epithelial Cells by Inhibiting the Ubiquitinated Degradation of Nrf2 RBX1 BACH1 KEAP1 MAF PC PMC8572421__F1 Contradictory roles of lipid metabolism in immune response within the tumor microenvironment LPL FAS HMGCR CD36 FASN PMC8303588__F2 TGFB Signaling: From Tissue Fibrosis to Tumor Microenvironment ARHA GRB2 MTOR PMC5595361__F1 Signaling pathways involved in GBM-induced apoptosis BAX FAS TNF PMC3417337__F1 Platinum drug action pathway HEL-S-22 ERCC1 XPA RRM1 ATP7B CCNH XPC MPO ATP7A NQO1 ERCC5 MDM2 ABCG2 ABCC2 CCND1 ABCB1 SLC31A1 PMC8303588__F1 TGFB Signaling: From Tissue Fibrosis to Tumor Microenvironment SMAD2 SMAD4 PMC8572421__F3 Contradictory roles of lipid metabolism in immune response within the tumor microenvironment STAT3 NR1C1 CD36 FASN MSR1 ARG1 FOXP3 IL8RB MTOR TGFBR1 PMC2575467__F5 A model of KCNQ1/KCNE1 function in embryogenesis KCNE1 SOX10 PMC6990114__F3 Hippo pathway plays vital role in mammalian immune system TBK1 DOCK8 CGAS FOXO1 FOXO3A RAB13 IRF3 FOXP3 RAC1 PMC5595361__F4 Interrelationships between programmed cell death TRADD IRF3 MTOR TRAF6 FADD MYD88 PMC6770252__F3 Biological origin of free radicals and their effect on cell viability BAX ATF4 XBP1 NOX4 PMC6770252__F2 Three major branches of the Unfolded Protein Response (UPR) signaling pathway and their interconnections ATF4 EIF2A XBP1 TRAF2 PMC6171904__F1 miR-451-AMPK-mTOR-cell cycle signaling pathway TSC2 TSC1 CAB39 CDKN2D CDKN2B MTOR PMC9257764__F5 Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review) STAT3 FAS LEP LEPR PMC9257764__F4 Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review) FOXO1 INS PMC12174925__F3 Dual Role of Autophagy in Periodontal Tissue under Periodontal Pathogen Infection and Diabetes Environment HGF ATG12 ATP6V0C MTOR IL1B PMC9281521__F5 Preliminary Study on Gene Regulation and its Pathways in Chinese Holstein Cows with Clinical Mastitis Caused by Staphylococcus Aureus TH VASP ALG11 GLS DEGS1 MAPK14 GNAS ABAT MYLK ITGA2 PLCB3 AASS HEL-S-302 HK2 CTH GLA SEPSECS AHCYL2 HGSNAT HEL-S-70p HEXB GPAM ABO MTM1 XYLB PMC6365498__F8 IPKB analysis of relationships among upregulated genes on silk film topography STAT3 CRK PRKCE HEY2 FLNB DTX2 JAG2 NUMB PPP2R1A PSEN1 FLNA NOTCH1 PMC6193676__F1 Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast DPH1 DPH6 DPH7 DPH5 PMC10298365__F5 Neonatal Meningitis-Causing Escherichia coli Induces Microglia Activation which Acts as a Double-Edged Sword in Bacterial Meningitis IL6 TNF IL1B PMC3514292__F1 Schematic representation depicting A; the protein synthesis pathway in skeletal muscle involving the mammalian target of rapamycin complex 1 (mTORC1) RHEB TSC2 EIF4B TSC1 IGF1 FOXO1 FOXO3A MTOR SIRT1 IRS1 PMC4526643__F2 Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model DDT GRAP2 ACOX1 CD2 NFE2L2 BAK1 PTP4A3 SATB1 CP PMC6952538__F1 RORGt functions play a central intermediary role in linking the control of cholesterol biosynthesis and metabolism to the regulation of immune responses and autoimmune disease HDAC1 NCOR1 AHR NCOA1 PMC5916931__F4 Dual role for glucocorticoid-induced leucine zipper in glucocorticoid function: tumor growth promotion or suppression? COX2 GC GCGR CD34 PMC6741141__F5 Metabolic pathway of aerial and submerged mycelia in the liquid surface culture of Cordyceps militaris HEL-S-162eP PDC CPO PMC4810089__F3 ARE- and GRE-signaling pathways stimulated through growth factors and growth hormones RGS2 JUN SP1 KSR1 RGS10 PTEN MTOR MYC FOS EIF4E RGS7 GRB10 FYN WEE1 CSK RGS4 GRB2 SRC CEBPB CDK4 PMC11542495__F2 Cytoprotective Mechanisms of HO-1: Heme oxygenase 1 is an enzyme responsible for the breakdown of heme into Fe²⁺, CO, and bilirubin, which is subsequently converted to bilirubin by BVR BACH1 KEAP1 FBXO22 PMC4810089__F2 Kinase signaling pathways involved in T cell receptor activation ZAP70 LAT PTEN SOCS3 MTOR TEC PLCG1 SHB FYN BCL10 F3 ITK CEBPB RAC1 FOS RUNX3 CEBPA CBL RUNX1 FOXO1 FOXO3A CSK JAK1 GRB2 LCK PMC11542495__F1 Schematic diagram of Nrf2 and Keap1 domain structure: Nrf2, is a transcription factor characterized by multiple functional domains, including Neh2, Neh4, Neh5, Neh6, Neh7, Neh1, and Neh3 KEAP1 RXRA PMC7390945__F4 Some involved pathways in C8- and C10-treated cells, on the basis of Metabolic Pathway analysis ACLY FAS GLS PMC6089198__F8 Mutation frequency of selected pathways WNK1 BAX PIK3CA CASP8 CHD8 APC PTEN TAP1 B2M HLA-DRB5 CTNNB1 CTBP2 RNF43 AXIN1 CASP3 TAP2 PMC7854758__F11 On the effect of antiresorptive drugs on the bone remodeling of the mandible after dental implantation: a mathematical model CR2 PTH PMC3827695__F4 Women and Lung Cancer: What’s New? STAT3 EGFR GRB2 PMC3057165__F1 Pathways by which toll-like-receptor signals and ligation of FcG receptor lead to the production of interleukin SYK TRAF6 MYD88 PMC2770656__F4 The tyrosine metabolism pathway where the differentially expressed genes of lung cancer were annotated DDT HIST1H1E PMC9552026__F5 Development of degradable magnesium-based metal implants and their function in promoting bone metabolism (A review) TRPM7 TRPM6 RUNX2 PMC8774087__F1 Calcium Signaling Pathway Is Involved in the Shedding of ACE2 Catalytic Ectodomain: New Insights for Clinical and Therapeutic Applications of ACE2 for COVID-19 BAD ADAM17 ACE2 PMC11542495__F3 Regulatory mechanisms for Nrf2/HO-1 signaling pathway: Under normal conditions, Keap1 mediates the ubiquitination and proteasomal degradation of Nrf2 by binding to Nrf2 and interacting with the CUL3 ubiquitin ligase complex JUN KEAP1 GPX4 NQO1 MAF PMC7317223__F4 Cell cycle and signalling pathway cascades in the Chinese ESCC subtypes AURKA NCAPG APC KIF20A SMAD4 CCNA2 PLK1 MYC SKP2 TGFBR1 TGFBR2 MKI67 PRC1 AXIN1 CDK2 CCNB1 HCTP4 CCND1 CDK4 PMC10573125__F1 The JAK-STAT signaling pathway by LNK in hormone receptor-positive breast cancer and non-tumor cells PRLR STAT3 PIM1 PRL CCND1 IL6R PMC4853852__F5 Genes under multiple regulatory controls in the PTEN pathway BAD RAF1 SYNJ1 PIK3CD AKT3 PIK3R1 PRKCZ PTEN IKBKG TGFBR1 FGFR2 MAST2 TGFBR2 IGF2R INSR ITGA2 FGFR4 FGFR1 FGFRL1 BMPR2 TNFRSF11A ITGA4 CNKSR3 TNFSF6 NTRK2 TGFBR3 MAGI3 CBL GSK3A MAGIX CDKN1A CASP3 BCL2 FGFR3 RRAS PREX2 PMC8267719__F3 Long Noncoding RNA GAS5 in Breast Cancer: Epigenetic Mechanisms and Biological Functions FOXO1 PTEN MTOR PMC7485347__F3 Functional and clinical significance of INI‐1/SMARCB1 CCND1 CTNNB1 PMC3581421__F8 Coupling and S1P signaling in mesenchymal cells S1PR1 S1PR2 SPHK1 PMC4357835__F2 KEGG pathway analysis VWF C6 CD59 HEL-S-62p PLAUR C4A PLAT F2R TFPI C2 F2 F10 F3 F8 PROC PMC524335__F7 Regulation of angiogenesis by the ancillary receptor endoglin SMAD1 DKFZp781O1323 SMAD2 PMC4674888__F12 LRRK2 in neurons in Parkinson's disease which is the fifth scored pathway map in MetaCore enrichment analysis results LRRK2 GSK3B AP2A1 AP2A2 HEL70 RDX PMC8490651__F6 Curcumin Extraction, Isolation, Quantification and Its Application in Functional Foods: A Review With a Focus on Immune Enhancement Activities and COVID-19 NEDD4 COX2 PMC4674888__F10 Cell cycle Role of SCF complex in cell cycle regulation which is the third scored pathway map in MetaCore enrichment analysis results ATR RBX1 APC ATM SKP1 CDC34 PLK1 SKP2 CDK4 PMC2967529__F8 Model for vertebrate limb induction and outgrowth PDLIM7 TBX5 FGF10 FGF8 FGFR2 PMC6164894__F2 Canonical TGFB1 signaling pathway TGFB1 SMAD2 SMAD4 PMC10551897__F9 SX Components-top 8 Targets-Pathways Network (Green hexagon node shows SX, pink circle nodes show the components, purple rectangle nodes show target genes, orange V-shape nodes show pathways and edges show the interaction between two nodes) STAT3 EGFR ERBB2 EP300 SRC PMC10551897__F8 SX Components-Targets-Pathways Network (Green hexagon node shows SX, pink diamond nodes show the components, blue rectangle nodes show target genes, orange ellipse-shape nodes show pathways and edges show the interaction between two nodes) CDC2 FLT3 AURKA CASP8 EGFR KIT PTGS2 MTOR PLK1 PTPN6 FGF2 PRKCE PRKCA CASP3 ERBB2 CDK2 FLT1 EP300 PTGER4 MDM2 KDR SRC CDC25B CSF1R PMC11706781__F1 Angiogenic cascade and metabolic reprogramming of ECs in tumorigenesis FAS PHGDH FASN PSAT1 ASNS CPT1A NOTCH1 PMC3009898__F6 Model for an alternative Okazaki fragment-processing pathway in vivo PIF1 LIG1 DNA2 FEN1 PMC8533981__F5 Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer BAX MTOR CCND1 CTNNB1 PMC11706781__F3 Interactions between immune cells and tumor endothelial cells in the tumor microenvironment TEC FASN ASNS VEGFA CPT1A PMC1993906__F16 Adenylyl cyclases are targets of multiple regulatory signaling pathways and respond differently, depending on which group they belong to CDC42 PLCB4 PLCB1 PLCB2 PLCB3 RHO SRC PMC1993906__F13 The G12/13 signaling pathway TEC BTK PMC6595688__F1 PKM2: Junction of Metabolic Networks and Signal Cascades TH F2 MAL CIT PMC514949__F9 Multiple pathways involved in tumorigenesis by VEGF-null tumor cells PC PMC7676225__F6 Caloric Restriction and Ketogenic Diet Therapy for Epilepsy: A Molecular Approach Involving Wnt Pathway and KATP Channels RHEB TSC2 TSC1 APC GSK3B TBC1D7 MTOR CTNNB1 PMC7311749__F1 Multiple oxidative stress factors induce pneumonia and AMPK-Nrf2 pathway inhibits pulmonary ROS accumulation UCP2 FOXO3A NQO1 PMC3706521__F3 Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation JUN BAD FAS SP1 EGFR IL3 CD14 IL4 TERT IGF1 PAK1 RELA HEL-S-69p GRB2 GAB2 LBP DIABLO PMC8393955__F6 Implications of a ‘Third Signal’ in NK Cells CXCL9 CCR5 CCR3 TNF CXCL10 TRAF6 IRAK4 RORA MYD88 RORC MAP3K7IP1 EBI3 CCR4 STAT4 JAK1 IL23R TYK2 IL12RB1 PMC3364930__F5 Subcellular localization of components of the PIWI-piRNA pathway and the proposed mechanism of TE suppression by this pathway HEL25 TDRD1 DNMT3L HIG-1 MOV10L1 MAEL PMC3706521__F4 Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation CDC42 NGF TGFA CD36 KDR GRB2 MMP9 VEGFA CD47 PMC4955761__F8 Pulmonary Epithelial Toll-like Receptor 4 Activation leads to Lung Injury in Neonatal Necrotizing Enterocolitis HMGB1 TLR4 CXCL5 PMC10502204__F2 ctDNA as a novel and promising approach for cancer diagnosis: a focus on hepatocellular carcinoma RPL5 ATR RPL11 APC LRP5 ATM LRP6 TERT MDM2 RPL13 RPS7 CTNNB1 PMC5434066__F8 Schematic diagram of Bc-specific induction of regulatory T cells via suppression of mTOR signaling pathway STAT3 SGK1 FOXP3 GATA3 PMC8047446__EV5 GOLPH3‐driven functional enzyme module CTRL GOLPH3 PMC4198693__F5 Identification of molecular pathways that are altered by Atbf1 inactivation in mouse prostates ZFHX3 GAA NR1H3 GPT2 HEL57 C7orf24 IKZF4 EHF ENPEP MCOLN2 TACSTD2 NR3C1 SLC22A4 ABHD2 MCM10 RARRES1 AHR ASNS LAMA3 FGF18 PMC4066335__F3 All diabetes drugs are likely to have indirect effects in the CNS by affecting circulating concentrations of glucose and insulin STAT3 IRS1 PMC5893801__F1 Therapeutic strategies to enhance immune checkpoint inhibitors by targeting tumor-associated macrophages (TAM) CD80 ARG1 MARCO CSF1R PMC5927721__F1 MiRNAs targeting the IGF1R pathway in its entirety TSC2 BAD TSC1 FOXO1 GSK3B GRB2 SHE PMC5711834__F16 Schematic model of the Keap1/Nrf2 signaling pathway KEAP1 MAF PMC6592248__F8 Proposed model to explain the molecular mechanism of Bmal1 deficiency influenced the HIF1Alpha-VEGF axis in the chondrocytes CRY1 PC PMC8920499__F1 Expression levels of sonic hedgehog pathway genes and their targets are upregulated in early clear cell renal cell carcinoma SUFU PTCH1 SHH BCL2 SMO VEGFA MYC CCND1 GLI3 PMC5850311__F1 Research and therapeutics—traditional and emerging therapies in systemic lupus erythematosus CD40 CD80 CD22 PMC6652233__F3 Stimulation of TLRs activates multiple signaling pathways TLR3 TLR4 CD14 TLR5 IRF3 TRAF6 MYD88 PMC9524569__F1 Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway CNTF EGF TGFA IL6 TNF IL1B PMC7281705__F3 Ang1 and Ang2 bind to Tie2 with similar affinities; however, whereas Ang1 is an agonist, the ability of Ang2 to activate Tie2 appears to depend on the cell type and context EGF GRB7 PAK1 SCD ARHA GRB2 RAC1 PMC7676225__F1 Metabolic effect of Wnt promotes the absorption of glucose in the neuron by increasing the affinity of the GLUT3 transporter for its substrate RHEB TSC2 TSC1 APC GSK3B TBC1D7 MTOR CTNNB1 PMC6437932__F8 Working model WTAP BNIP3 PMC10380571__F2 Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies ATR ATRIP CDK6 RNF168 CDK2 ATM CDK4 PMC8353884__F7 Proposed Model of IKK:NFKB:Notch Signaling Control by SLX4IP and RAP1 HEY2 PIAS1 TERT SLX4 HES1 RBPJ SLX4IP PMC7175209__F1 Induction and initiation of cellular growth control and senescence via p53 or P16INK4A pathways ATR CDK6 ATM CDK4 PMC6683960__F1 Gold nanoparticles-loaded hydroxyapatite composites guide osteogenic differentiation of human mesenchymal stem cells through Wnt/Beta-catenin signaling pathway APC GSK3B RUNX2 CTNNB1 PMC9531660__F3 Species-specific transcriptomic changes upon respiratory syncytial virus infection in cotton rats ADAR FAS PML SOCS3 TRAF3 IFNG CDK6 TLR4 IL18 TLR7 CDK4 IL1B CCND3 BAX CASP9 PLG RNASEL IRF3 IRF7 IL6 RAC1 NLRX1 TRIM25 TLR3 CASP3 FADD NUP98 PMC7663720__F2 Pharmacological inhibitors targeting the Wnt pathway that are currently being tested for cancer treatment BCL9 APC LRP5 LRP6 CTNNB1 PMC7663720__F1 Wnt signaling pathway CDC42 ROR1 BCL9 JUN APC ROR2 LRP5 LRP6 ATF2 RHO CTNNB1 PMC7226210__F2 The most relevant molecular pathways and targeted agents in TNBC TSC2 TSC1 BRCA1 PTEN GRB2 IRS1 PMC6271057__F5 GSK3B and phospho-GSK3B regulate milk synthesis and DCMEC proliferation via the mTOR/S6K1 signaling pathway FAS SCD PRL MTOR CCND1 PMC9280125__F1 Homocysteine Metabolism in Pregnancy and Developmental Impacts DHFR HEL-S-61p PMC11932845__F1 FGF/FGFR signalling pathway in mammary epithelium and TNBC GRB7 PMC10242111__F4 Venetoclax durable response in adult relapsed/refractory Philadelphia-negative acute lymphoblastic leukemia with JAK/STAT pathway alterations SOCS1 STAT3 RAF1 IL13 MCL1 SOCS2 MTOR MYC PTPN6 CSF3R MPL BCL2L1 STAT5B BCL2 JAK1 GHR PMC6358786__F4 Alterations of the PI3K/Akt-Cyclin D1 pathway in cell cycle progression from G1 to S phase in 2-cell embryos CDK6 CCNE1 CEND1 CDKN1B GSK3B ATM SDK2 PTEN CCND1 CDK4 PMC9288709__F5 Transcriptome profiling and co-expression network analysis of lncRNAs and mRNAs in colorectal cancer by RNA sequencing SYK BAD RBL2 PTEN CD19 MYC RAC1 EIF4E TSC2 TSC1 BCR CD37 MEI1 MDM2 GRB2 PMC8246550__F3 Epigenetic regulation of cancer stem cell formation and maintenance TF ME3 TET2 TET1 TET3 F11 EZH2 DROSHA TDG PMC4114568__F4 PleiotRHOpic CDC42 RIC8A TRIO GDNF PHACTR4 PTK7 ARHA RAC1 RHOU PAK1 EDNRB CXCR4 RET PMC7403980__F7 Mechanistic scheme of anti-inflammatory signaling pathways of KMU-470 NLRP3 COX2 TLR4 IL1B MYD88 PMC6458768__F1 CD22 structure and signaling pathway BCR CD22 PMC6502913__F7 USP7 functions in several canonical signaling pathways NOTCH1 CTNNB1 PMC3040416__F3 Proteins oxidized by extracellular EhCySS control cell signaling and morphology RPL11 RPS4X SLC5A3 ATP1B1 EEF1G SPTBN1 MAP2 VCP CKAP4 RPS16 SDHA POSTN MYO1C MYH9 ATP6V1E1 RPS17 RPL4 DYNC1H1 EEF1A1 NDUFS1 PMC6284331__F1 Effect of changes in ECM‐mediated signalling pathways CD44 DDR2 RHO SRC UNK PMC4107774__F1 The Hippo signalling core cassette in mammals LATS1 LATS2 PMC8396993__F1 Perspectives on Precision Medicine in Chronic Lymphocytic Leukemia: Targeting Recurrent Mutations—NOTCH1, SF3B1, MYD88, BIRC3 CDKN1A DLL4 JAG2 NRARP ADAM10 MYC DLL3 PMC3083963__F1 Brain-derived neurotrophic factor (BDNF) gene and stimulated intracellular signaling cascades after activation of tropomyosin-related kinase (Trk)B GRB2 SHE BDNF PMC8394001__F3 Guardians of the Genome: BRCA2 and Its Partners POLD3 RAD51 BRCA2 FANCA PRIMPOL VHL FANCD2 SMARCAL1 MRE11A DNA2 BRCA1 HLTF PALB2 FBXO18 PMC10840523__F1 Therapeutic Potential of Fingolimod in Diabetes Mellitus and Its Chronic Complications S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 PMC11978054__F11 Impact of hydroxyurea and metformin on Gamma-globin induction involves complex molecular pathways KLF4 MAPK1 MYB BAD LMO2 IGF2BP1 GATA1 SP1 BCL11A HDAC1 NFE2 MAFF FOXO3A GCNT2 KLF1 PMC3437205__F3 Pathway analysis of the hypermethylated genes in lymph node metastasis including their biological processes and association to breast carcinogenesis and neoplasm metastasis BMP6 CDKN2A BRCA1 APC PMC9603382__F1 Pathogenesis of Port-Wine Stains: Directions for Future Therapies PLCB3 MTOR VEGFA ANGPT2 PMC3748765__F1 TCDD-induced CTLA-4 on AhR-Treg activating the tolerogenic IDO pathway and suppressing the acute GVH response IFNG STAT1 CD80 AHR PMC7840460__F7 Dmrt1 repressing immune response but promoting proliferation of mGSCs DMRT1 TLR4 IRF3 TRAF3 TRAF6 TNF CCND1 PMC8964056__F4 Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling ROR1 ROR2 ARHA RAC1 DAAM1 PMC10308077__F2 Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective LPL PPARG EBP CCR5 FGF21 UCP1 GPR19 CD44 ANGPTL3 ACVR1 GPNMB FNDC4 SIRT1 PMC4810646__F1 OAS-RNase L pathway STAT1 STAT2 IFNAR2 IFIT1 IFNAR1 RNASEL IFIT2 ISG15 JAK1 TYK2 PMC8251975__F3 Wnt/B‐catenin signaling: Structure, assembly and endocytosis of the signalosome CDC42 PAK1 TSG101 EEA1 PMC4294682__F6 Proposed model of hPer2 and hp53 interaction and function BAX SFN MDM2 PMC9038718__F7 Mechanism by which LINC00858 affects colon cancer STAT3 PCNP PMC4736325__F2 Synaptic binding partners and signaling pathways of BAI adhesion-GPCRs TIAM1 ADIK ADII HBD RHO MDM2 C1QL1 RAC1 ADIJ PMC11554578__F2 Exemplary Ca2+ signaling microdomains RYR2 RYR3 TRPM7 ORAI1 STIM1 RYR1 PMC3675375__F1 Wnt signaling pathway in diabetes mellitus APC LRP5 LRP6 CTNNB1 PMC4266039__F7 Biological activities of triterpenoids and saponins in animals STAT3 EGFR CXCL1 BCL2 MMP9 CXCR4 PMC3543845__F2 Top network, “DNA Replication, Recombination, and Repair, Gene Expression, Cancer”, formed by genes exhibiting altered expression in MLT-pretreated MCF-7 cells upon MMS exposure relative to untreated MMS-exposed cells DYNLL2 TRAPPC1 WRN C2CD2 CR2 THEM5 HEL-S-128m PARP11 CEP63 ZNF264 INTS2 ZNF805 SPAG5 GTF2IRD2B PMC9540430__F8 Transcriptomics for child and adolescent tuberculosis BAX IFNGR1 IFITM2 IRF9 IFIT1 IFITM1 IFNG IFNGR2 MED14 RELA MX1 ISG15 AGA FITM1 OAS1 TYK2 PMC7033203__F2 Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis IPP MVD AGA MVK PMC5297991__F3 Functional analysis of the network containing validated segregating variants JAK1 TYK2 PMC4215617__F3 MAPKs in the DAMP perception in innate immune cells TF TLR4 NRIP3 MYD88 PMC9682695__F1 Early postnatal alterations in follicular stress response and survival in a mouse model of Classic Galactosemia HEL-S-19 ATF4 PMC11215075__F5 Ezetimibe, Niemann-Pick C1 like 1 inhibitor, modulates hepatic phospholipid metabolism to alleviate fat accumulation TG ACSL1 PEMT PC FADS2 PMC3586350__F8 Proposed Adipose Stromal Cell-derived IL-6 signaling pathway STAT3 JAK1 TYK2 PMC6175696__F5 CA biosynthetic pathway starting from C3 and C5 precursors CAD HEL-S-62p PAH PMC8704776__F2 Telomeres and Cancer NHP2 SRSF11 NOP10 CTC1 TPP1 PMC4813474__F10 Proposed model of the p8-regulated autophagy signaling pathway in response to palmitic acid stress ATF4 EIF2A PMC3143721__F5 Putative crosstalk between D1and TrkB receptors in striatal direct pathway neurons controlling PPD mRNA expression AMPH RAF1 BDNF PMC4126105__F1 Proposed integrated model for tissue-type plasminogen activator (tPA)- and plasminogen (Plgn)-mediated modulation of blood–brain barrier (BBB) permeability during thrombolysis in ischemic stroke PIGN PDGFRA CCR2 LDLR PMC8458751__F7 Analysis of miRNAs Profiles in Serum of Patients With Steatosis and Steatohepatitis POR LIPA BAX CIT PMC6966475__F3 EMT inducers from the chronic tumor microenvironment and EMT repressors from natural anti-inflammatory compounds and pro-resolving lipids CDH2 LTB STAT3 EGF HMGB1 GPR32 GSK3B GRB2 TRAF6 SIRT1 PMC3921497__F4 Chitinase 3-like 1-associated Beta-catenin activation signaling pathway, which is inhibited by methylxanthine derivatives TBP CCND1 CTNNB1 PMC3392648__F1 Insulin signaling pathways BAD INSR GSK3B PTEN GRB2 PMC3025702__F2 Combination Treatment with Progesterone and Vitamin D Hormone May Be More Effective than Monotherapy for Nervous System Injury and Disease NGF BAD BDNF PMC9388302__F2 Essential Role of FoxO1 in the Regulation of Macrophage Function FOXO1 PML SIRT1 SIRT6 PMC9530868__F7 Ubiquitin‐specific protease 28 deubiquitinates TCF7L2 to govern the action of the Wnt signaling pathway in hepatic carcinoma USP28 TCF7L2 FBXW7 APC CCND1 CTNNB1 PMC11126050__F7 KIT structure and signalling TK1 KIT MTOR PMC5489693__F7 Gene interaction network related to lipid metabolism of DEGs between WC and WRR chickens LPL SLC27A1 MYPN DAP CCDC50 ABCA1 CPT1A HIVEP2 CLIP2 ZFAND5 ASXL2 PMC6405884__F3 Schematics shown miRNAs which might regulate mGluR/mTOR/LTD signaling RHEB PTEN MTOR PMC6156597__F13 Mapping of the DE genes exclusive to the oval morphotype on KEGG metabolic pathways– SVIP BAX SELL SEL1L BAP1 PML AIRE ATP6 APOB ATF4 REL DNER RET PMC3281623__F9 Toxoplasma acquires fatty acids through a complex network of synthesis and uptake ELOA tmp_locus_29 ELOC PMC8744729__F2 Ribosomal Protein S6: A Potential Therapeutic Target against Cancer? STAT3 PPM1D PCNA CAB39 DDIT4 ULK1 GSK3B PTEN STK33 LCMT1 MYC PLK1 AKR1B10 PLCG1 CDK6 RB1CC1 ATM EIF2A MDM2 CDK4 GRPR CDH2 RPS6 PIM2 MAP4K3 RPL11 PLD2 SOX2 AKR1C1 HEL-S-70p VHL DRAM1 RHEB TSC2 TSC1 CDK5 HAP1 EIF3C CDK2 EIF3B AKR1C2 SIRT1 PMC7864206__F1 Essential molecules of the mammalian Hedgehog signaling pathway and their interactions SUFU PTCH1 DISP1 SMO GLI3 PMC4003416__F2 Targets of Twist proteins in the DNA damage response pathway BAX ATR ATM MDM2 MYC PMC1502028__F4 EGFR and mTOR signaling network, and signaling mediator effects associated with rapamycin and/or EKI-785 treatments STAT3 TSC1 EGFR PTEN MTOR EIF4E PMC8004491__F1 Two pathways that collect and deliver axonal cargo for degradation in lysosomes ATG16L1 ATG12 ATG5 PMC6156597__F14 Mapping of the DE genes exclusive to the oval morphotype on the SNARE interactions in vesicular transport pathway issued from the KEGG metabolic pathway– ST14 SNAP23 BET1 STX6 SNAP29 STX8 VAMP4 STS VAMP7 USE1 STX16 STX11 SYP STX18 STX7 STX2 STX4A STX3A PMC7595202__F6 Indole hydrazide compound ZJQ-24 inhibits angiogenesis and induces apoptosis cell death through abrogation of AKT/mTOR pathway in hepatocellular carcinoma HIF1A IRS1 EIF4E PMC7230310__F6 Knockout of IRF7 Highlights its Modulator Function of Host Response Against Avian Influenza Virus and the Involvement of MAPK and TOR Signaling Pathways in Chicken TBK1 STAT1 STAT2 IL18 MX1 IRF7 JAK1 CPSF4 TRAF6 PMC5842190__F5 Proposed pathway for regulation of endothelial cell signaling by breast cancer cell-derived EVs and a function-blocking CD47 antibody SIRPA CD47 PMC3193436__F1 Model describing the proposed role of Rap1GAP in the control of GDNF-induced Ret signaling CDC42 RAP1GAP TIAM1 GDNF VAV2 DOK4 RAC1 RET PMC5811339__F1 Hydrolytic enzymes tested in this study participate in sphingolipid metabolism in the lysosome as indicated by their respective gene names (blue) GLA GLB1 PMC4304881__F5 Summary of results of RPPA analysis of EGFR signaling in MCF‐10A + EGF, MCF‐10A + AREG and SUM‐149 cells STAT3 EGFR APC FASN GSK3B HEL-S-28 PTEN AREG MTOR RHEB HRAS TSC2 RICTOR TSC1 ITGB1 MOS DKK1 NRAS GRB2 SRC GAB2 PMC5864190__F1 Models of RIPK1 regulation by IKKA/B and MK2 phosphorylation TLR4 RIPK1 TNF PMC3733802__F2 Prioritizing Disease Candidate Proteins in Cardiomyopathy-Specific Protein-Protein Interaction Networks Based on “Guilt by Association” Analysis PLN MYL3 MYL2 DMD DAO PMC4402072__F5 Schematic model of AREG in the Warburg effect and tumorigenesis EGFR MLX AREG PMC8327086__F8 Berberine Reduces AB42 Deposition and Tau Hyperphosphorylation via Ameliorating Endoplasmic Reticulum Stress TG BACE1 GSK3B ELF2 APP PMC8469852__F3 Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders AIP AHR PMC6941108__F3 Visualization of lncRNAs and mRNAs in enriched pathways CD80 CDC20 UBE2C BUB1B NCAPG HMMR MYBL2 CDC6 NEK2 KIF20A HLA-DPA1 HLA-DPB1 TYMS SOCS3 PLK1 CXCL8 NCF1 KIF23 HJURP CDCA5 CD74 MHC2TA CCNB1 TOP2A CDC2 CD209 CENPF E2F2 RRM2 KNTC2 AIM2 ESCO2 PTTG1 CCNE2 GM2A TK1 MCM10 CDC45 GINS2 FGL2 IFI27 HCTP4 PMC5364818__F2 Canonical and Noncanonical Inflammasome STAT1 NLRP3 TLR4 FADD MYD88 PMC9688488__F4 HIF-1A Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases MMP7 TIMP3 MMP10 MMP2 MMP3 MMP9 MTOR RUNX2 MMP11 EMCN PMC12162297__F1 Mechanisms by which a high-fat diet (HFD) affects hematopoietic stem cells (HSCs) TLR4 SMAD2 NOTCH1 TGFBR1 PMC9688488__F1 HIF-1A Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases STAT3 IL33 NOTCH1 PMC12162297__F2 High-fat diet (HFD) and energy-restricted diet modulate the function of hematopoietic stem cells (HSCs) SZT2 TSC1 IGF1 PMC8238937__F1 MYD88, NFKB1, and IL6 transcripts overexpression are associated with poor outcomes and short survival in neonatal sepsis CD80 TLR9 IRAK1 TLR5 IL6 TNF CCL2 CXCL8 IRAK4 MYD88 STAT1 TLR1 TLR3 TLR4 TLR7 PMC7791172__F1 NOD2 regulates AMP A‐defensins expression and AMPs sorting in PCs LRRK2 FGF9 RELB NOD2 FGFR3 REL RAB2A PMC4710177__F2 Ribosomal Proteins and Human Diseases: Pathogenesis, Molecular Mechanisms, and Therapeutic Implications ATR ATM MDM2 PMC3255869__F1 TLR4 signaling pathway TIRAP TLR4 CD14 MYD88 PMC8774788__F5 Metformin Affects the Transcriptomic Profile of Chicken Ovarian Cancer Cells MMP7 STAT3 HGF RSAD2 ANGPT2 FOS FABP6 GCN1 MADCAM1 TK1 NFKB1 TNFSF10 AID PMC10384366__F11 Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells KLF4 TCF3 SOX9 CTNNB1 PMC7785807__F4 miRNA expression on cellular connectivity and activities with different Toll-like receptor regulation and molecular function of the cellular signaling pathways (A) TBK1 TIRAP CTSK CD14 IL4 IRAK1 TLR5 CCR3 CPO IRF3 IRF7 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 IL16 TLR8 TLR7 LBP FADD PMC6614373__F3 Signaling crosstalk at receptors and adaptors SOCS1 STAT1 TIRAP TLR4 CD14 JAK1 MYD88 PMC6614373__F2 NFKB signaling pathway TRADD TIRAP TAB3 TLR9 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 TLR3 TLR4 TRAF5 TRAF2 PMC6614373__F1 Pathogen-Responsive NFKB IFNG STAT1 TLR4 CD14 JAK1 MYD88 PMC8981087__F2 Autophagy in the Function of CD4+ T Cells and the Development of Chronic Inflammatory Diseases CD44 BAX ROS1 BAK1 PMC8116828__F1 Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis SPP2 PHB2 SPNS2 LEP KY TNF SPP1 PMC5851872__F1 Molecular Regulation of Follicle-Stimulating Hormone Synthesis, Secretion and Action ATF3 SF1 EGR1 GNRHR CTNNB1 PMC7982593__F7 Graph abstract HCC manifestation is typically preceded by hepatic fibrosis and cirrhosis LATS2 SMAD2 SMAD4 MYC PMC12036158__F3 Regulation of epithelial-mesenchymal transition (EMT) in idiopathic pulmonary fibrosis (IPF) by ferroptosis SLC3A2 TGFBI BACH1 GPX4 SLC7A11 PMC12036158__F2 Regulatory pathways of ferroptosis POR SLC3A2 LPCAT3 DPP4 FACL4 SLC7A11 DHODH PMC9570383__F2 Metabolic Reprogramming in Tumor Endothelial Cells OXCT1 TEC GLS PHGDH F2 HK2 PSAT1 ASNS CPT1A PMC7911352__F2 Cyst(e)ine-glutathione-GPX4 axis regulates ferroptosis GPX4 BAP1 HEL-S-89n SLC7A11 ATF4 SEPHS2 HEL-S-26 HEL-S-64p PMC6337248__F1 Intracellular signaling pathways that regulate Nrf2 KEAP1 MAF PMC7911352__F4 Other metabolic pathways that regulate ferroptosis VDAC3 FOXM1 NEDD4 GPX4 SQSTM1 GLS2 SLC38A5 PMC3694431__F5 Interaction networks of significantly regulated genes from interconnected neurons 7 days post-infarct CGA PXN BMPR1A SEMA4B SKP2 KDM6B EZR INHBB SOCS5 ATN1 FBLN2 NOTCH1 HTT RIN2 TIMP3 SP1 GNB2 APOE AIP DLG4 PDYN EZH2 ACTR2 GPAM ADFP TRIM54 HLA-C LMNA GNAI3 SH3GLB1 VAMP2 NEFL GNB1 KLK6 GIPC2 NELL1 NME2 BCAN KHDRBS2 GREM1 EIF5B ZHX1 AQP4 GNAI1 FEN1 NEF3 NEFH OMD SMURF1 ELAVL1 RGS5 GNB4 RRAS GNG11 DKFZp686P0251 PMC4087127__F2 Scheme of ErbB dimers related MAPK and PI3K pathway activation ERBB3 RPS6 EGF HRG ERBB2 MTOR PMC9143262__F2 Platelet-Derived Growth Factor Pathway in Pulmonary Arterial Hypertension: Still an Interesting Target? PDGFD PDGFC PMC3567829__F9 miR-486 sustains NFKB activity by disrupting multiple NFKB-negative feedback loops MAP3K7IP1 TRADD ITCH CYLD PMC11153983__F6 Illustration of the mechanism of DHA inhibiting T-ALL cell viability, inducing ferroptosis by modulating the SLC7A11-GPX4 signaling pathway and provoking ER stress SLC3A2 GPX4 SLC7A11 ATF4 PMC9143262__F4 Platelet-Derived Growth Factor Pathway in Pulmonary Arterial Hypertension: Still an Interesting Target? CASR STAT3 STAT1 ORAI1 FOXO4 STIM1 HEL-S-11 MTOR CCND1 PMC2951227__F7 Hypothetical model for Rad18-dependent activation of the FA pathway in response to bulky DNA adducts RAD18 MCM7 PCNA MCM3 MCM5 MCM6 MCM2 POLN PMC8235983__F5 Study on the Molecular Mechanism of the Herbal Couple Sparganii Rhizoma-Curcumae Rhizoma in the Treatment of Lung Cancer Based on Network Pharmacology TH DEK KY ATM UNG APP MYC TNF PMC12061915__F1 Macrophages in cSCC CHI3L1 CD40 IL13 CTSK ARG1 CD200 TNFRSF21 PMC11174690__F5 SIRT signaling pathway by active ingredients in goji berries TFAM SIRT3 FAS FOXO1 NRF1 CPT1A SIRT1 PMC8178373__F2 Two common mechanisms of aurora kinase A (AURKA) synthetic lethal interactions RB1 ARID1A AURKA SMARCA4 PMC11174690__F4 PI3K-Akt signaling pathway by active ingredients in goji berries BAX NLRP3 FOXO1 BCL2 PTEN MTOR LBP PMC11174690__F3 Fas/Fasl signaling pathway by active ingredients in goji berries FAS CASP3 LBP FADD PMC8149889__F2 Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy KIR2DL4 CCL3L3 PTN HLA-G PBX1 XCL2 LILRB1 KIR2DS1 PMC7692643__F6 Proposed mechanisms of YAP/TAZ activation in CMS4 CRC LATS1 LATS2 APC GSK3B CTNNB1 PMC7692643__F2 Hippo pathway LATS1 LATS2 PMC2971463__F3 SLIT/ROBO pathway: a regulator of cell function with implications for the reproductive system DCC HGF PI3 GSK3B GRB2 CXCR4 CTNNB1 PMC6670099__F10 The role of PLIP1 in TAG biosynthesis during development of wild-type (WT) and dgat1 seed LPA FAS DGAT1 LPCAT2 PC PMC3983565__F4 MAPK signalling cooperates with loss of APC to promote adenoma development EGFR APC GSK3B BMF CCND1 CTNNB1 PMC5026403__F2 Complement activation and immune regulation HEL-S-62p C2 CFD CP PMC7520283__F2 DNA methylation and histone acetylation involved in OA‐FLS inflammation STAT3 EGR1 VCAM1 TRAF6 IRS1 IL1B PMC7520283__F1 MiRNAs involved in OA‐FLS inflammation SP1 FOXO3A MTOR CCL2 IL1B PMC9616825__F8 Schematic illustrating the working model of diabetes-induced bone marrow dysfunction PPARG CXCL12 TGFB1 SP7 PMC7520283__F4 Wnt/B‐catenin signalling pathway in OA‐FLS inflammation STAT3 APC GSK3B FOXC1 CLK2 CTNNB1 PMC7520283__F3 Activated NF‐KB signalling pathway in OA‐FLS inflammation TF VCAM1 IL1B PMC3017463__F4 Schematic illustartion of microglial (A) and astrocytic (B) events taking place in the spinal cord in neuropathic pain CX3CL1 BDNF CCL2 PMC10573612__F2 Exploring the Cellular and Molecular Mechanism of Discoidin Domain Receptors (DDR1 and DDR2) in Bone Formation, Regeneration, and Its Associated Disease Conditions DDR1 PTEN DDR2 MAP2 RHO PMC8070386__F2 Influence of extracellular acidification on melanoma progression KLF4 CAD AXL HEL-S-53e SOX2 MMP2 MMP9 PMC8273913__F4 Integrated Analysis of Microarray and RNA-Seq Data for the Identification of Hub Genes and Networks Involved in the Pancreatic Cancer CDC42 TH EGF VASP HGF TGFA SMAD2 HEL-S-28 MTOR VEGFA ARHA FLNA HEL114 DAP PMC9223566__F6 Exercise Training Enhances BDNF/TrkB Signaling Pathway and Inhibits Apoptosis in Diabetic Cerebral Cortex BAD RAF1 BCL2 GRB2 FADD PMC6321433__F3 Cholesterol biosynthesis deficiency syndromes POR NLRP3 MVK IL1B PMC8273913__F3 Integrated Analysis of Microarray and RNA-Seq Data for the Identification of Hub Genes and Networks Involved in the Pancreatic Cancer CDC42 EGF HEL-S-28 RHO PMC7468434__F1 Mitochondrial dysfunction in microglia TREM2 NLRP3 CD36 MCU PMC8533960__F3 Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer MYB BAD GAL RBL2 PTEN CD19 RAC1 IRS1 RHEB FAR1 BRCA1 BCR NOG PROC PMC8662355__F2 Roles of Gasdermin D in Coronavirus Infection and Evasion GSDMD NLRP3 AFP PMC3382127__F7 Toll-Like Receptor 3 and Suppressor of Cytokine Signaling Proteins Regulate CXCR4 and CXCR7 Expression in Bone Marrow-Derived Human Multipotent Stromal Cells SOCS1 STAT1 TLR3 IRF1 SOCS3 CXCR4 PMC8533960__F5 Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer CD44 VWF CD36 CHAD CD47 PMC8485071__F6 Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review SYK EIF4G1 GRB7 KRAS PMC8162686__F2 Peg3 downstream genes involved in major metabolic pathways ACLY SUCLA2 HMGCR IDH3B FASN HEL-S-26 PMC11754522__F1 Ceramide biosynthesis pathways (created by Figdraw 2 CERS3 CERS5 FAS CERK SMS CERS1 tmp_locus_29 CERS2 PMC11754522__F3 Mechanisms by which nutritional interventions alter ceramide metabolism (created by Figdraw 2 CERS3 CERS5 SMS CERS1 tmp_locus_29 CERS2 APOB PMC10382948__F1 Hylemon-Björkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC5041507__F1 Pathway interaction network of targets of apoptomiRs in breast cancer ARID3B MTMR3 MCL1 EPO IRAK1 PTEN SLC7A11 MTOR TRAF6 LMTK3 TPM1 BCL2L1 BCL2L2 PRKCE CCNE1 CCNJ EPOR MEGF9 MUC1 CSNK2A1 RTKN HEL-S-283 CCND1 NOTCH1 RAD52 TIMP3 feat TP53INP1 PIM1 AXL HEL-S-133P EZH2 ANXA1 ENPEP ARHA GPD1L MTDH FOXO1 SNCG FOXO3A FOSL1 RPS6KB1 CASP3 BCL2 TRAF2 SIRT1 CDK9 ARID4B PMC4695870__F2 Melanoma cells develop resistance to MAPK inhibitors by mutating (mut) or altering expression of a number of proteins which reactivate MAPK signaling and/or activate alternative survival pathways such as the PI3K pathway KDM4A NRG1 FOXD3 HGF AXL NF1 EGFR BRAF EZH2 BPTF PMC6951973__F5 ClueGO pathway enrichment analysis of genes in the yellow module PRB2 KCNJ16 CST2 KRT16 PROCR CHAD ULBP2 DSC2 CA12 PLAT C2 MUC2 LAMB3 DPP4 UNG CFTR RPRM CISH ACE2 PMC8282197__F6 Identifying Biomarkers from Transcriptomic Signatures in Renal Allograft Biopsies Using Deceased and Living Donors CD14 GSTM5 VCAN CDH16 GSTM4 LY96 ALDH1A3 GSTM3 CCL21 TLR4 CX3CL1 SULF1 S100A12 CD163 CCND1 UNK PMC7589702__F7A Resveratrol Rescue Indoxyl Sulfate-Induced Deterioration of Osteoblastogenesis via the Aryl Hydrocarbon Receptor /MAPK Pathway AHR RUNX2 UNK PMC7724827__F2 Interplay between EVA71 infection and autophagy APOBEC3G ULK1 SNAP29 PML IRF7 STX17 MYD88 PMC5103287__F1 DGKA and DGKζ in T cell activation and anergy PLCG1 EGR1 DGKA FOXO1 EGR2 DGKZ PMC3861040__F5 Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion CFP SMAD4 FABP4 PTH FGF23 PMC9256556__F1 TNF in the liver: targeting a central player in inflammation RIPK3 BAX TRADD MLKL TRAF5 RIPK1 TNF TRAF2 FADD PMC7073155__F2 BPA action on placental growth CYP11A1 BCL2 PMC7547615__F1 Pathogenesis and immunomodulation of COVID -19: 1 CCS IL33 IRF3 CXCL10 ACE2 PMC9256556__F2 TNF in the liver: targeting a central player in inflammation TRADD C2 TRAF5 TRAF1 TRAF2 PMC7720688__F3 Biological mechanism of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection TMPRSS2 ADAM17 ACE2 IL1B PMC1859939__F5 Signal transduction pathways involved in Ha-ras-mediated AEG-1 induction MAX GSK3B MYC PMC6886443__F5 Proposed model of (defective) AP-3 dependent acquisition of VAMP8 during Weibel-Palade bodies (WPB) maturation VWF VAMP8 CD63 PMC7338464__F7 CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils CDH2 CXCL5 GC PMC4139831__F1 Wnt/Beta-catenin signaling pathway TNKS APC LRP5 LRP6 CTNNB1 PMC4191885__F5 Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain SHH FOXA2 GATA3 PMC5390594__F2 Notch signaling pathways are shown mainly above IRAK2 SOCS3 IRF8 EIF4E PMC5390594__F1 AMPK and JNK signaling pathways are shown above HEL-S-31 IL16 SIRT1 IL1B PMC8125975__F3 Pediatric Rhabdomyosarcoma: Epidemiology and Genetic Susceptibility HRAS RAF1 SOS1 NF1 SHOC2 BRAF PTPN11 GRB2 KRAS PMC5308909__F7 Schematic diagram illustrating the possible interplay between the EGFR and CK2 signaling pathways that regulate GBM cell proliferation EGFR PTEN CDC37 CTNNB1 PMC8721005__F8 Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway MFN2 ELF2 ATF4 PMC8577836__F7 Schematic model of the role of tumor-derived extracellular vesicle (TEV) and CD300a in tumor immunity CD300A TLR3 IRF3 PMC7291288__F4 ER stress is involved in NLRP3 inflammasome activation NLRP3 REL IL1B PMC8670134__F2 gcMECM: graph clustering of mutual exclusivity of cancer mutations RASSF2 CASP8 RAF1 SOS1 EGFR BRCA2 MAL KSR1 BRAF PTPN11 E2F7 FANCA KRAS FGFR2 SOST PLAT BRCA1 PDGFRA RELA FGFR4 SI ERBB2 SCRIB SHC3 PMC9390238__F6 An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy BAG3 PTEN MTOR RET PMC4731230__F2 MuSC function are altered in aging STAT3 GDF11 CTNNB1 PMC5366789__F1 Suggested signaling pathways for induction of the immunosuppressive catabolic enzyme indoleamine 2,3-dioxygenase (IDO1) in vertebrate dendritic cells (DCs) CD40 CD80 SMAD2 SMAD4 TRAF3 TRAF6 TRAF2 PMC7205985__F7 REGGamma-dependent regulation in ATC dedifferentiation SMAD2 PAX8 SMAD4 PMC9926763__F8 Sirtuin 3 regulation: a target to alleviate Beta-hydroxybutyric acid-induced mitochondrial dysfunction in bovine granulosa cells SIRT3 FAS ULK1 MTOR PMC4535331__F1 Reflex control of immunity HMGB1 ARC NCL PMC6799818__F5 Additional gut microbial metabolites regulate host immunity and metabolism IL25 AHR WNT3 IL1B CTNNB1 PMC6412895__F2 Signal transduction pathway of EGFR EGFR GRB2 MTOR PMC3989546__F1 Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer DNMT3B STAT3 JAK3 IL4 GRB2 JAK1 MYC GAB2 TYK2 PMC6147766__F2 Role of Helicobacter pylori in the reprograming of cellular and molecular programs related to invasive behavior CD44 SP1 PLG CTNNB1 PMC6487278__F4 Schematic model for Cbl-b in BCR- and CD40-mediated signaling pathways Activation of CD40-dependent signaling pathway is mediated primarily by several TNFR-associated factor (TRAF) protein family members including TRAF2, 3, 5, and 6 CD40 SYK BTK BCR PLCG2 TRAF5 BLNK LYN TRAF3 TRAF6 TRAF2 PMC9390238__F2 An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy RHEB RPS6 EIF4B BAG3 IGF1 EEF2 PTEN CASTOR1 SLC38A9 EIF4E PMC8141729__F7 Beta-Asarone Ameliorates Beta-Amyloid–Induced Neurotoxicity in PC12 Cells by Activating P13K/Akt/Nrf2 Signaling Pathway BAX KEAP1 MAF PMC7547615__F3 Mode of action of MSC's for treating COVID-19: 1.Ifusion of MSC's 2 EGF HGF MSC BNIP3 ACE2 PMC6296341__F1 Two synthesis pathways of fucosylation FUT1 FUT8 FUT4 FUT6 POFUT4 FUT9 FUT2 FUT5 FUT3 FUT7 GMDS POFUT3 PMC6428271__F5 Comparative proteomic study reveals the enhanced immune response with the blockade of interleukin 10 with anti-IL-10 and anti-IL-10 receptor antibodies in human U937 cells HTRA2 TBK1 BAD FAS TRADD MCL1 CYCS GAS2 MTOR MDM2 LIMK1 ACIN1 HEL-S-28 TNF DFFB EIF4E RHEB ARHGDIB DFFA CDC37 TRAF2 DIABLO LMNA FADD SPTAN1 PMC8274634__F1 Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control RGS2 ARC AgRP SET PMC3238469__F2 Gene expression changes in cell cycle pathways HUS1 CCNI2 ATR MSH2 MAPKAPK2 ATM EZH2 PTGS2 FANCA POLE FANCC MAPK3 PMC3547545__F1 An illustration of the IIF pathway genes.Notes: Arrows indicate the direction of signal transduction PIK3CA PIK3R3 PIK3R2 AKT3 IGFBP1 PIK3R1 IGFBP4 IGFBP2 PDK3 PDK2 INS IGFBP6 PDK4 IGFBP5 INSR F3 PMC5516854__F3 Visualizations of Wnt pathway reconstructions DVL1 FZD5 PIK3CA SMAD1 GNAO1 PLCB4 NFATC2 FZD10 EGFR SMAD2 GSK3B PIK3R1 SMAD4 RYK TCF4 FLNA MAPK3 CSNK2B CTNNB1 FZD8 FZD3 CSNK1E PAX2 PRKCA WNT1 CSNK2A1 FZD1 PLCB3 SRC NOTCH1 CDH2 MAPK1 FZD2 APC ROR2 LRP5 FZD7 LRP6 RPS27A DVL2 TCF3 PLCB1 AXIN1 DVL3 MAP3K7 PLCB2 CFTR LEF1 PMC6034273__F10 Interaction among MCP-1/CCR2 signaling, TLR4, and GSK3B in ethanol-induced neuroinflammation TLR4 CCR2 GSK3B IL6 MYD88 PMC11865046__F7 TMYXP's key blood components and mechanisms for treating the elderly CHD HSP90AB1 HEL-S-22 FAS TGFB1 ITGA4 CD27 PTGS2 TNF CXCL8 ITGAV TGFBR1 RB1 BCL2L1 RPS6KB1 CASP3 CHUK PMC5507964__F1 TLR7/TLR9 and B cell receptor (BCR) ligands incite B cell signaling cascades STAT3 SYK DOCK8 BANK1 TLR9 IRAK1 BLNK IRF3 IRF7 TRAF6 IRAK4 MYD88 BLK UNC93B1 BTK BCR PLCG2 TLR7 LYN BIK PMC5336341__F2 Proteomics and tracing experiments reveal the presence of previously unappreciated metabolic pathways in mature RBC.(A) An overview of the central metabolic pathways that are reasonably active in RBC in the light of proteomics evidence ACLY FH ASL SMS LAT MAL CTH ARG1 SLC19A1 MTHFD1 PIG59 SHMT1 HEL-S-32 HEL-S-26 PSPH PMC10239240__F5 Mettl3 Mediated m6A Methylation Involved in Epithelial-Mesenchymal Transition by Targeting SOCS3/STAT3/SNAI1 in Cigarette Smoking-Induced COPD STAT3 SOCS3 IL6 IL6R PMC4958247__F10 Ehrlichia chaffeensis TRP120-mediated activation of canonical Notch signaling pathway and inhibition of TLR2/4 expression ADAM17 TLR4 NOTCH1 PMC8848293__F2 Maintenance of protein homeostasis in glia extends lifespan in C. elegans ATF4 XBP1 PMC8085043__F1 Current Concepts and Advances in Graft-Versus-Host Disease Immunology FAS ARG1 CTLA4 PMC3293584__F1 Schematic of folate-mediated one-carbon metabolism in the cytoplasm and nucleus DHFR SHMT1 TYMS PMC10854459__F8 Anticancer role of JAC in AGS cells CDH2 STAT3 BAD CDK6 WNT3A CDK2 CDK4 CTNNB1 PMC8458965__F2 MAVS: A Two-Sided CARD Mediating Antiviral Innate Immune Signaling and Regulating Immune Homeostasis TRIM31 OGT TBK1 MAVS RNF5 PPM1G FAF1 PCBP1 OTUD1 TRIM21 NLRX1 RNF125 TRIM25 RNF34 NLK PMC7461825__F1 Role CRP on the innate immune system and tumor progression CRP PTEN MTOR PMC7565831__F3 Amino acid sensing by mTORC1 RHEB ARF1 CASTOR1 SLC38A9 PMC7906923__F1 Molecular signaling pathways implicated in neuroblastoma ALK EGFR HIF1A FZD1 MDM2 MTOR BDNF CTNNB1 PMC2890581__F7 Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis and Anagen Induction Shown by Using Keratinocyte-Specific TAK1-Deficient Mice EDARADD TRAF6 EDAR CTNNB1 PMC9048116__F7 Autotaxin signaling facilitates B cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency LPA SIRT3 ENPP2 PMC6336527__F2 UV-induced cutaneous tanning response MC1R POMC PC DCT TYRP1 PMC8712140__F13 To Predict Anti-Inflammatory and Immunomodulatory Targets of Guizhi Decoction in Treating Asthma Based on Network Pharmacology, Molecular Docking, and Experimental Validation CSF1 RAF1 EGFR AKT3 TNF MAP3K14 IKBKG MAP3K7IP1 IL16 NFKB1 RELA IKBKB NFKBIA CHUK MAP3K7 MAP2K1 MAP2K2 GRB2 TNLG7C PMC1617297__F2 Cell-signaling networks induced by Pichinde virus infection as analyzed using the Ingenuity pathway analysis knowledge base TP73 XPA RFC1 ERCC2 E2F2 PGR ZNF148 PTEN TERT MYC FOS ID3 RB1 PRKCI CBL E2F3 DPT RELA PLCB1 EDNRA NFKBIE EGR2 FHIT DCTN1 PMC6053276__F1 A simplified representation of the HIPPO pathway LATS1 LATS2 NF2 PMC6492170__F1 Schematic representation of iron metabolism in the yeast model CMIP FES HEL-S-11 PMC7445288__F6 Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate APC GSK3B BRAF EHF PTEN PTPRK RSPO3 ERBB3 RB1 TCF7L2 FBXW7 RNF43 MAP2K4 NF1 ERBB2 ATM ARID2 PSIP1 CCND1 ELF3 PMC8198587__F3 Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression KAT5 RUVBL1 LRP5 LRP6 LEF1 CTNNB1 PMC8458965__F3 MAVS: A Two-Sided CARD Mediating Antiviral Innate Immune Signaling and Regulating Immune Homeostasis TBK1 NLRX1 MAVS NDFIP2 F2 PPM1G PMC12014800__F2 Value-added products derived from fatty acids and derivatives, which can be synthesized by yeast cell factories with tuned fatty acid profiles FAS PALM PMC9367355__F5 The Cancer Stem Phenotype by Long Non-Coding RNAs HEL-S-68p EZH2 PTEN PMC9367355__F4 The Cancer Stem Phenotype by Long Non-Coding RNAs HDAC1 PHB2 CTNNB1 PMC10559995__F1 Signaling Pathway of Estrogen Receptor TF EGF EGFR PMC10559995__F3 Estrogen metabolism pathway in humans UGT1A3 UGT1A9 STS PMC5866458__F1 A change of view: homologous recombination at single-molecule resolution RAD51 DMC1 SSB PMC7731470__F4 Illustration of the effects of polycystins dysfunctioning on EGFR and MAPK/ERK pathway EGF IGF1 EGFR GRB2 PMC8353397__F9 Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis JUN ROCK2 MIP CXCR4 PMC7922523__F4 TGFB/EMT signalling in pSS SMAD2 TGFBR3 SMAD4 TGFBR1 PMC6316148__F2 Relationship between mechanical loading and sclerostin expression SOST LRP5 LRP6 PMC10552500__F3 Nutraceutical-mediated signaling pathways underlying some neuroprotective processes BAX NGF COX2 BACE1 APP ADAM10 BDNF PMC9367355__F3 The Cancer Stem Phenotype by Long Non-Coding RNAs CD44 TCF7L2 IGF2BP1 CBY1 SOX2 SP3 PMC11827473__F6 Anti-tumor effects of ArcA on the aggressive behavior of metastatic melanoma cells MMP9 CDK4 PMC8261167__F2 Emerging mechanisms and targeted therapy of ferroptosis in cancer TF POR IREB2 LOX HMGCR KEAP1 GPX4 LPCAT3 HEL-S-102 FACL4 ADA PMC8261167__F1 Emerging mechanisms and targeted therapy of ferroptosis in cancer SLC3A2 ATF3 GLS GPX4 BAP1 SLC38A1 CTH SLC7A11 HEL-S-64p PMC5492138__F5 Mechanism of encoding the NSC modules GAA GCG GCA PMC8261167__F4 Emerging mechanisms and targeted therapy of ferroptosis in cancer IFNG STAT3 SLC3A2 HMGB1 HCAR1 TGFB1 AGER GPX4 ARG1 SLC7A11 JAK1 KRAS PMC2263022__F6 Superposition of 'omics' data on maps CENPF TRAF4 BAX PCNA APC TTK ATM CENPE CENPA XPC PMC6695732__F6 Model of ESRP1-mediated cell cycle G1-phase arrest ESRP1 CDC20 CCNA2 PMC7322029__F7 Cartoon comparing canonical Hippo signaling with signaling by Legionella LegK7 LATS1 YAP1 PMC7793796__F5 CAM-DR in leukemia CD44 GSK3B VCAM1 CTNNB1 PMC5713154__F4 Cell signaling pathway scheme of metabolic alterations due to Zika virus infection MME CPA3 MGRA CTSA MTOR ACE2 PIKFYVE PMC8424139__F5 Diagram depicts the regulation of retinoid metabolism by PI3K-AKT pathway in RPE ADH7 RPE RDH8 LRAT RPE65 RDH10 RDH5 RDH12 PTEN PMC3761196__F8 This figure depicts a model of the lipid synthesis genes in the human mammary epithelial cell during secretory activation according to cell compartment ACLY DGAT1 VLDLR FACL4 ABCA1 INSIG1 ACSS2 ABCG1 BTN1A1 SLC25A1 CH25H HEL-S-32 GK5 LPL FASN FLJ10842 GPD1L ESRRA ACACB TG GPAM THRSP SCARB1 ACSM3 DBI LPIN1 XDH ADFP FDFT1 PMC3761196__F7 Cell compartment view for network of lipid metabolic genes highlighting the role of SREBF1, THRSP, and ESRRA curated by ingenuity pathway analysis (IPA) ACLY PPARG EHHADH LEP CD36 FACL4 PPP2CA FADS2 ACACA ACADM ACSS2 ACADVL IDI1 FDPS NR1A2 HEL-S-26 PHYH LPL ACOX1 NR1H3 SQLE FASN SREBF2 ESRRA HMGCS1 ACACB SDHB NR1C1 DLAT ACSL1 GPAM HMGCR SCARB1 HSD17B1 PMVK MVD DHCR7 FDFT1 ELOVL6 PMC11353167__F2 MAPK signaling pathway CDC42 JUND JUNB ATF2 RHO RAC1 PMC7999830__F7 The proposed model HMOX1 NFE2L2 IL1B PMC11353167__F1 FCERI signaling pathway SYK FYN BCL10 LAT LYN GRB2 GAB2 PMC6065096__F8 R431C mutation induces hyperproliferation, hypermotility and ER stress-induced apoptosis in podocytes CD2AP MTOR RAC1 PMC3282414__F2 Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities SHANK3 HRAS NF1 SHANK2 PTEN ARC PDK2 MTOR PMC7022340__F6 Working model of the roles of Beta-catenin and US3 in the DNA-sensing signaling pathway TBK1 CGAS APC GSK3B IRF3 CTNNB1 PMC11313500__F2 Molecular pathway mechanisms of cytokines and chemokines associated with inflammation for the progression of pulmonary hypertension SMAD2 MYD88 PMC6921378__F5 Molecular models of the potential role of proteins involved in the Nrf2 – mediated response to NCC exposure HEL-S-92n HEL-S-8a APC ATF4 PMC3761885__F2 Proposed regulation of cardiac Per2 NEDD8 RBX1 PER2 EGFR SKP1 ADORA2B PMC9489100__F2 Lung involvement in monogenic interferonopathies TBK1 CGAS MAVS STAT2 IRF9 IRF3 COPA POMP STAT1 ADA2 IFNAR2 USP18 IFNAR1 ATM ISG15 TREX1 NGLY1 DNASE2 TYK2 ACP5 PMC6076434__F8 Schematic view of pathways regulating IL-1A expression in hRPE cells TIRAP TLR4 IRF3 IRF7 IL1B MYD88 PMC3283716__F1 Novel Classification of Lung Cancer into Molecular Subtypes BAD BCL2 PTEN MTOR KRAS PMC5331196__F1 Sensing infection and tissue damage STAT1 MAVS STAT2 IRF9 IRF3 PMC5580489__F3 Host DNA damage response pathways FANCD2 TOPBP1 ATR RAD50 ATRIP MRE11A BRCA1 H2AX BRCA2 ATM FANCA PMC7471766__F3 Classic and trans-signaling IL-6R STAT3 ADAM17 JAK1 PMC10551140__F7 Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway NLRX1 BNIP3 BNIP3L MTOR PMC4339430__F6 Proposed role of CCL21/CCR7 axis in lymphangiogenesis VEGFC CCL21 CCR2 CCR7 PMC7497240__F2 A) Comparison of the putative biosynthetic gene cluster (BGC) of tjipanazole biosynthesis in F TJP1 STAC PMC8542988__F3 Shedding Light on Microbial “Dark Matter”: Insights Into Novel Cloacimonadota and Omnitrophota From an Antarctic Lake RAN GHB2 PMC2900152__F9 Proposed DAP12 signaling pathway in macrophages and osteoclasts TREM2 SYK VAV3 GRB2 PMC7907466__F1 Complement Cascade in HIE C6 C7 C2 C9 PMC4474341__F1 Biochemical pathways IVD MCC PMC8466551__F1 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis GPR161 SUFU GSK3B SMO PMC3913970__F1 BCR/BTK signaling pathway SYK BTK BCR LYN MTOR PMC8466551__F3 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis CDH2 BAX MMP14 NRP2 MMP9 VEGFA CCL5 CCL2 SNAI1 SOX9 CCND2 MMP2 MMP3 BCL2 ZEB2 ABCG2 TWIST1 CCND1 ABCB1 PMC3679383__F1 Pathways of GPL biosynthesis in eukaryotic cells: temporal regulation of GPL-synthesizing enzyme activities LPA PGP PTN PSD PEMT PC PMC8466551__F6 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis LRP5 SHH NRP2 LRP6 MTOR VEGFA KRAS CTNNB1 PMC2642659__F2 Visualization of molecular interaction and reaction networks in the KEGG database CDC42 SIAH1 ROCK2 APC LRP5 SMAD4 IQGAP1 LRP6 GIP IGF1R ARHA CTNNB1 LMO7 RBX1 INSR FER FGFR1 CER1 ERBB2 SKP1 NLK SRC PROC DAAM1 PMC8466551__F5 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis SP1 PTCH1 SHH SMO PMC5785435__F2 Bevacizumab-Induced Hypertension: Clinical Presentation and Molecular Understanding CASP9 BAD COX1 APP PMC5564072__F5 T cell receptor (TCR) signaling pathway in melanoma (modified from the BioCarta database) ZAP70 TH FYN RAF1 LAT GRB2 LCK PMC8965842__F4 MiR-223 as a Regulator and Therapeutic Target in Liver Diseases VTA1 STAT3 NLRP3 PKNOX1 APOE LDLR CXCL2 CXCL10 PMC11930265__F9 LTA promotes aerobic glycolysis (AG) and M1 polarization in macrophages by activating the NFKB signaling pathway BAD LTA HK2 HIF1A PMC3959571__F1 Q6 biosynthesis in S COG5 C6 COQ7 COQ4 COQ3 COQ2 COQ9 COQ5 PMC3711327__F7 A model for the regulation of transcriptional induction of ICL1 and FBP1 by the PIPTC PI3 FBP1 TBP PMC5943571__F1 Pathway for glycosphingolipids (GSLs) biosynthesis B3GALT4 PMC11049046__F6 KEGG pathway of the PI3K-Akt signaling pathway with target genes of our known miRNAs shown in red stars and targets of novel miRNA NC_060925 RHEB SYK MYB TSC2 BAD BCR CD37 RBL2 CD19 GRB2 MTOR PMC11049046__F5 KEGG pathway of the MAPK signaling pathway with target genes of our known miRNAs shown in red stars and targets of novel miRNA NC_060925 MAX ECSIT FAT4 EGF FAS ASL TRADD CD14 TNF DAO FLNA MEF2C BTK NLK TRAF2 PMC4550685__F1 Intracellular pathways of factors regulating adipogenesis, lipogenesis and lipolysis in the adipocyte LPL STAT3 TG PDE3B FAS INSR AK2 GC PMC7646947__F3 Receptors and substances involved in metabolism that affect muscle protein synthesis and degradation in cancer cachexia NR1i1 PDK4 IGF1 PMC7646947__F1 Molecules and signaling pathways involved in muscle protein synthesis and degradation STAT3 IGF1 IGF1R MTOR PMC8018731__F11 NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated D2 Receptor Stimulation: Involvement in Behavioral Repetition HEL70 CS SRC PMC7851083__F1 Important events during research development of macropinocytosis in cancers CDC42 PALM ARHA PMC8466551__F7 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis MED12 SPOP SOX9 SKP1 IGF1R PMC3031870__F1 MTORC1 and mTORC2 signaling branches RHEB TSC2 TSC1 PTEN PMC3335081__F9 Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation MSC RUNX2 SIRT1 PMC7851083__F3 Mechanism of extracellular proteins internalization through macropinocytosis EGFR PTEN ATF4 RAC1 PMC3285217__F1 Drosophila signaling pathways that regulate humoral responses DAP FADD MYD88 PMC3331679__F2 mTOR signaling in growth control and disease MAF1 EIF4B MAP4K3 SGK1 ULK1 IPMK PTEN YY1 RHO EIF4E RHEB TSC2 EEF2K TSC1 NF1 EEF2 PMC4149926__F1 Cytomegalovirus microRNAs CDC42 SNAP23 CCNE2 RAB5C EID1 RAB11A ATP6V0C VAMP3 MAPRE2 MICB BRCC3 CD34 PMC9308931__F8 Unveiling of brain transcriptome of masked palm civet (Paguma larvata) with chronic infection of Toxoplasma gondii TIRAP TANK TLR9 SIGIRR IRF3 IRF7 IRF8 TNF TRAF6 IRAK4 MYD88 TLR1 BTK TLR3 COX2 TLR4 TLR8 PMC7984366__F2 Endogenous estrogen regulates the proliferation and differentiation of NSPCs EGFR GPER SRC PMC7984366__F3 Estrogen-like molecules activate the classical estrogen signaling cascade and alternative pathways GSK3B GPER SIRT1 CTNNB1 PMC5332937__F1 Canonical WNT signaling pathway GSK3A APC LRP5 LRP6 CCND1 LEF1 CTNNB1 PMC10297136__F3 Signal pathways associated with lung adenocarcinoma TSC2 STK11 TSC1 NF1 EGFR APC ATM MDM2 MTOR PMC6743980__F2 Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics VLDLR EGFR PLG RHO TGFBR1 PMC8692119__F1 Novel contributors to B cell activation during inflammatory CNS demyelination; An oNGOing process ICOS BCR RELA RELB GSK3B CD19 MTOR TRAF2 PMC5759931__F6 Proposed working model by which boehmenan exerted anti-proliferative activities in A431 cells STAT3 EGF EGFR PMC8085043__F2 Current Concepts and Advances in Graft-Versus-Host Disease Immunology STAT3 SYK BTK CSF1 ROCK2 GC IL21R JAK1 CSF1R PMC10297136__F5 Glioblastoma multiforme (GBM)-related signal pathways RB1 NF1 EGFR CDKN2B MTOR CDK4 PMC11700987__F2 Staphylococcus aureus prevents Nrf2 pathway activation in THP-1 macrophages through upregulation of MAPK/p38 and downregulation of p62/SQTM1, scheme modified from [35] KEAP1 CCL2 TNF PMC11700987__F1 NRF2/KEAP1 signaling pathway adapted from [17] RBX1 KEAP1 GCLM NQO1 PMC11700987__F6 Keap1/Nrf2 signaling pathway plays a crucial role in the cellular response to P HMGN2 HBEGF TGFA KEAP1 EGFR PMC11700987__F4 Listeria monocytogenes evades the host immune response by Tim-3-dependent inhibition of the Keap1/Nrf2 signaling pathway KEAP1 CD36 PMC9592927__F3 Emerging role of circular RNAs in drug resistance of non-small cell lung cancer STAT3 FAM83A EGFR KLF8 CTNNB1 PMC11700987__F3 Activation of Nrf2 in S KEAP1 MAF SFN TNF PMC7272282__F1 PI3K pathway TSC2 TSC1 INPP4B PI3 PTEN EIF4E PMC4367834__F5 Dopamine biosynthesis and degradation and the genes coding key enzymes TH ST1A5 PNMT DBH PAH ALDH3A2 DDC AKR1B1 MAOA PMC6770301__F2 Regulation of EMT at different molecular levels: upregulation of the WNT pathway, PI3K/AKT pathway, and RAS/RAF/MEK/ERK/MAPK pathway and downregulation of the TGFB/Smad pathway lead to the activation of EMT through downregulation of E-cadherin MAPK1 STAT3 FOXC2 APC SOX2 GSK3B SMAD4 TCF4 IL1B SNAI3 CTNNB1 PMC7272282__F3 Crosstalk between PI3K signaling and DNA damage repair pathways FANCD2 EMSY RAD51 BRCA1 BRCA2 UBE2S ATM PMC7272282__F2 Cell cycle checkpoints CDC2 ATR CDK6 CCNE1 WEE1 CDK2 ATM SSB CDK4 PMC4626177__F6 Pathway network analyses of upregulated genes from early stage (stages II and IIIa) TNBC CDH2 STAT1 CTNND2 KLK5 CLU IGFBP2 TNFRSF11B PMC4626177__F7 Pathway network analyses on upregulated genes from late stage (stage IIIc) TNBC RAB3B EGF SNAI1 HOXA13 PAX2 MAPK10 SNAP25 LEF1 MSX2 PMC3928651__F2 Solving Glycosylation Disorders: Fundamental Approaches Reveal Complicated Pathways GMPPB KRTCAP2 DPM2 TUSC3 DDOST RFT1 ALG9 ALG3 DPM3 ALG12 ALG8 MAGT1 ALG10 ALG13 DPM1 ALG1 STT3A STT3B PMC9592927__F2 Emerging role of circular RNAs in drug resistance of non-small cell lung cancer STAT3 EGFR ADAM28 PMC5578163__F1 Physiology of the VHL-HIF pathway along with proposed etiopathogenesis that leads to metastatic ccRCC BMI1 EGFR CCR7 SHH EPO MTOR CXCR4 TWIST1 VHL PMC4775036__F5 Main canonical pathways induced by cigarette smoke extract FLT3 CNTF NGF TREM1 HIF1A CTNNB1 PMC1609106__F8 Regulation of insulin pathway phenotypes by AKT-1 and PDK-1 activation PMC6059118__F1 USE1 is a critical ubiquitin-conjugating enzyme in lung cancer cells USE1 UBA6 RGS4 PMC11539471__F2 Mechanisms of action of clinically studied CAR-T targets in gliomas STAT3 EPHA2 IL13 MTOR VEGFA IL13RA2 PMC7845757__F7 Mechanisms underlying DAC-paracetamol interaction LOX CYP2E1 COX2 PMC7177421__F1 Receptor 4 (TLR4) general signalling transduction pathway TLR4 CD14 IRAK1 IRF7 TRAF6 IRAK4 MYD88 PMC8869442__F2 Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19 USP15 MAVS TRIM25 USP4 TLR4 USP18 IRF3 IRF7 ISG15 OTUB2 CYLD PMC7105732__F1 “Four Hits” Hypothesis of IgA Nephropathy TH TLR4 TLR9 TLR7 PMC3558870__F1 The potential disruption of hepatic GH signaling pathways by MC SOCS3 GRB2 GHR IRS1 PMC7522543__F6 The prostate cancer pathway PIK3CA SOS1 PIK3CD GSK3B FGFR2 RB1 CCNE1 E2F3 PI3 PDGFC FGFR1 MDM2 CREB1 ETV5 CASP9 KLK3 ERG HRAS NKX3-1 TCF7L2 CDKN1A FOXO1 SOS2 CDKN1B BCL2 GRB2 TF BAD CREB3 TGFA EGFR AKT3 BRAF PTEN MTOR IKBKG CTNNB1 CREB3L2 PLAT CHUK ATF4 CCND1 HSP90AB1 TMPRSS2 PDGFD SRD5A2 E2F2 PDGFA MMP9 TCF7L1 KRAS ARAF CCNE2 HEL-S-125m NFKB1 IKBKB PDGFRA RELA NFKBIA ERBB2 CREBBP EP300 MAP2K1 MAP2K2 PMC4362880__F1 Beta-amyloid precursor protein (BAPP) processing in Alzheimer’s disease (AD) and age-related macular degeneration (AMD) TREM2 TYROBP CD33 TSPAN12 ADAM10 PMC3808429__F7 Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology STAT3 PLCG1 SHC1 EGFR ERBB2 HIF1A VEGFA JAK1 SRC CTNNB1 PMC3808429__F6 Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology HEL-S-72p EGFR NFKB1 NFKBIA GSK3B PIK3R1 CHUK ERBB2 CTNNB1 PMC2665046__F3 Multivalency-Assisted Control of Intracellular Signaling Pathways: Application for Ubiquitin-Dependent N-End Rule Pathway NTAN1 ATE1 PMC7051146__F1 Pro-viral roles of autophagy during virus infection MAVS ATG12 ULK1 MTOR PMC7969890__F1 Elements of the classical and alternative complement pathways, separated by the unique and common aspects HEL-S-62p C2 C4B_2 PMC4276135__F2 Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling CCND3 BLNK IL7R RAG2 RAG1 IRF4 ID3 PMC4682379__F4 Transcription_P53 signaling pathway XPA ATR MAP4 MTA2 FHL2 VEGFA XPC PIAS2 CTNNB1 RANBP2 SUMO1 PIAS1 ATM TDG PMC7676935__F2 Summary of the possible signaling pathway between gut microbiota-bile acids axis and IBS-D NR1i1 NGF PMC5053351__F7 The Pga1-mediated signal transduction pathway, showing the effectors AC and PKA previously reported in different fungi, along with newly identified effectors and proteins and their relation with the cellular processes regulated by Pga1 RAN TK1 PMC3499368__F1 Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors PMC6013028__F2 Direct effects of thyroid hormones on hepatic lipid metabolism LPL CDX2 ABCG8 ABCG5 HMGCR SOAT2 CYP7A1 LDLR FDPS PMC7199749__F1 Genomic stabilization by TTK KNL1 TTK PMC8453015__F3 Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases TBK1 CGAS IRF3 PMC4452497__F9 UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1 EDNRB PMC11477111__F6 Regulatory role of FMR1/FMRP on BMPR2 in granulosa cells BMP15 BMPR2 ALK GDF9 FMR1 PMC5915462__F1 Pathways of deoxyribonucleotide metabolism in mammalian cells INS DHODH ADSL PMC11667896__F2 GLP-1 (glucagon-like peptide-1) plays a vital role in neuroprotection and regeneration through multiple mechanisms BAX CASP9 CASP3 NRF1 PMC3519947__F1 Simplified diagram illustrating the mTOR signaling pathway PSD MTOR PMC9122672__F1 Bile Acids and Nuclear Receptors in Acupuncture in Improving Crohn's Disease CYP8B1 CYP7A1 HSD3B7 CYP7B1 CYP27A1 PMC4395138__F1 Extrinsic and intrinsic pathways of apoptosis FAS APP TNF FADD PMC2736107__F2 In addition to the hypothesis outlined in , a number of other mechanistic pathways could potentially lead to the formation of products 3-5 () ARX PMC7590567__F1 Viral Infections: Negative Regulators of Apoptosis and Oncogenic Factors CSA2 BAD TRADD MCL1 PTEN BMF HRK TRAF2 BIK FADD PMC5143325__F1 Reactions induced by oxytocin OXT ALPL OXTR PTEN MTOR FOS PLAA SIAE PRKCE NPPA TRPV2 LNPEP RELA CHUK PMC2610675__F6 Arrestin-3 is essential for the activation of Fyn by the luteinizing hormone receptor (LHR) in MA-10 cells ARR3 FYN EGFR GRB2 PMC6616656__F2 Long non-coding RNA acting within the NODAL signalling pathway FOXH1 LEFTY1 DAND5 SMAD2 LEFTY2 SMAD4 NODAL PITX2 PMC5817857__F2 An RTK and the downstream PI3K/AKT pathway RICTOR MTOR DEPTOR PMC9574935__F1 SARS-CoV-2 accessory proteins in immune evasion MAVS TRIM25 IRF3 JAK1 PMC2939266__F3 Dopamine-sensitive signaling via adenylyl cyclase (AC), phospholipase C (PLC), and phosphatidylinositol-3-kinase (PI3K) systems DRD2 PTEN MTOR EIF4E PMC114459__F1 Mechanisms of ISG induction STAT1 STAT2 IRF3 TYK2 PMC3044944__F6 Hypothetic model for TGF-Beta-regulated KLF4 proteolysis KLF4 SMAD2 APC PMC5386709__F7 Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells TSC2 ATR PTEN GRN PMC4272576__F2 Candidate genes influenced by Zn2+ or involved in Zn2+signaling and metal ion homeostasis associated with the development of ASDs SHANK3 SHANK2 MTF1 COMMD1 PMC5577170__F7 Schematic representing the key role of IFNA and LPS-activated monocyte-derived exosomes in brain endothelial stimulation PTN TLR4 IL6 VCAM1 CCL2 IL1B PMC7587305__F3 XRCC1 participates in BER by facilitating transfer of DNA damage PARP1 PMC9529500__F3 Effectiveness and Mechanisms of Low-Intensity Pulsed Ultrasound on Osseointegration of Dental Implants and Biological Functions of Bone Marrow Mesenchymal Stem Cells BMPR2 SMAD9 SMAD1 DKFZp781O1323 APC GSK3B SMAD4 CTNNB1 RHOD SUFU SHH SMO CXCR4 PMC6099164__F2 Transforming growth factor‐B (TGF‐B) promotes T helper 17 (Th17) differentiation through multiple mechanisms STAT3 TGFA RUNX1 ROCK2 SMAD2 SMAD4 IL2RA IL21R SOCS3 ARHA IRF4 FOXP3 PMC9098327__F4 Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer RBX1 NQO1 MAF AHR PMC8080601__F3 Processing, extracellular regulation, and signaling mechanisms of GDF11 and MSTN SMAD9 SMAD1 ACVR2A FSTL3 BMP1 DKFZp781O1323 GDF11 SMAD2 SMAD4 pp6425 PMC3541634__F1 Schematic of TGFB1 signaling pathway and its regulation SMURF1 SMAD2 SMAD4 PMC8468667__F7 MicroRNA-Based Risk Score for Predicting Tumor Progression Following Radioactive Iodine Ablation in Well-Differentiated Thyroid Cancer Patients: A Propensity-Score Matched Analysis BCL2L1 AGO2 DICER1 E2F3 PIK3R1 BCL2 PTEN MYC TNF SIRT1 PMC7587305__F5 XRCC1-APLF – an interaction between two DNA scaffolds PNKP APTX APLF PMC2800820__F1 Multiple pro-inflammatory mediators in the tumor microenvironment increase the accumulation of MDS cells and enhance their immunosuppressive activity HEL-S-62p COX2 IL1B PMC6011883__F2 Complexes formed by mutant p53 and their roles in breast cancer INSR SENP1 DAB2IP TNF RAC1 PMC8230471__F8 Sustained Release of Insulin-Like Growth Factor-1 from Bombyx mori L. Silk Fibroin Delivery for Diabetic Wound Therapy EGF BAD IGF1 MTOR IRS1 PMC3518431__F2 Autophagy modulation as a potential therapeutic target for diverse diseases NBR1 ULK1 PI3 PMC10299133__F1 HGF/MET signaling pathway and most frequent alterations in NSCLC STAT3 HGF KRAS PMC3518431__F1 Autophagy modulation as a potential therapeutic target for diverse diseases RHEB INSR ULK1 TFEB RAP2B PMC2841835__F1 Host defence signaling pathways in Caenorhabditis elegans model TPH1 SGK1 PMC7028286__F5 Top two modules from the PPI interaction networks CD81 ENG TFRC TIMP1 GLS CD9 HK2 APP CD63 GOLPH2 SLC1A1 PMC5415012__F1 Schematic representations of selected modes of cross-talk between autophagy and the secretory pathway SEC16A TECPR2 ULK1 ULK2 PMC8709197__F7 Global Metabolic Map Defines the Effects of a Si-Based Biostimulant on Tomato Plants under Normal and Saline Conditions PURA CGA SI PMC7662679__F1 Monoclonal antibodies: types and mechanisms of action CD80 PMC4721243__F4 DDN, (b) GDNPN, and (c) GDNnon-PN of PI3K events in ERBB2 signaling (M570) pathway EGF PIK3CA BAD EGFR DDN AKT3 RPS6KB2 PTEN EREG FOXO4 CHUK MDM2 CREB1 CASP9 ERBB4 ERBB3 NRG2 TSC2 NRG1 HBEGF RICTOR GSK3A CDKN1A FOXO3A CDKN1B ERBB2 GRB2 PMC4721243__F3 DDN, (b) GDNMES, and (c) GDNnon-MES of Integrin AIIb B3 signaling (M760) pathway SYK SHC1 SOS1 DDN PTPN1 ITGB3 HEL-S-78p RAPGEF4 CRK PDPK1 APBB1IP RAP1A CSK FGA TLN1 GRB2 SRC PMC3446651__F2 Viral proteins inhibit nucleic acid receptors of the intracytosolic innate immune response C6 TBK1 MAVS IRF3 TRAF6 PMC11676821__F3 Action of PAK2 in the regulation of different signaling pathways in different cancers MCM7 CDK12 SP1 SOX2 FACL4 MTOR STX17 PMC7418434__F1 Pathways controlling ferroptosis, necroptosis, and pyroptosis RIPK3 NLRP3 MLKL GPX4 RIPK1 PMC6959074__F3 Roles of sirtuins may be involved in nicotine/nAChR-mediated signaling pathway SIRT3 CHRNA3 SIRT7 CHRNA5 SIRT4 SIRT5 SIRT2 SIRT1 CHRNB4 SIRT6 PMC6959074__F2 nAChR-mediated signaling pathways that lead to lung cancer progression STAT3 EGF EGR1 GATA1 RAF1 SP1 EGFR SOX2 YAP1 FGF2 MYD88 NLRP3 SRC PMC9368800__F1 Delivery of Nucleotide Sugars to the Mammalian Golgi: A Very Well (un)Explained Story GPR89B SLC35C1 SLC35A3 SLC35A2 SLC35B4 ATP2A2 SLC35A1 PMC12128733__F14 Effect of Withania extracts in two doses on the eicosanoid signaling pathway ALOX15 ALOX12 PTGFR PMC4498740__F3 Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells LAT RELA HEL-S-11 PMC7417311__F6 Current Sarcoidosis Models and the Importance of Focusing on the Granuloma TNFRSF18 CSA2 JUN PMC4498740__F2 Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells COMP LAT PMC6599319__F1 Simplified schematic illustration of pathways for Wnt/Beta-catenin, ERK/MAPK and PI3K/Akt and PGE2-metabolism COX1 C2 APC GSK3B PTGES PMC5002928__F3 Overlapping RAS/MAPK and PIK3CA/AKT/mTOR signaling pathways and potential therapeutic targets TSC2 TSC1 SOS1 NF1 BRAF GRB2 MTOR PMC3744367__F1 mTOR couples cellular nutrient sensing to organismal metabolic homeostasis RHEB MLST8 TSC2 TSC1 MTOR PMC3360922__F1 Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances TF BMP6 TFR2 STAT5B HAMP HFE HIF1A FECH TMPRSS6 NDFIP1 HFE2 VHL PMC6484299__F7 Schematic representation showing that B‐arrestin2 (ARRB2) negatively regulated NOD2 signalling pathway through the association with TRAF6 in cerebral ischaemia/reperfusion injury ARRB2 NOD2 MMP9 TRAF6 PMC7041253__F2 Lipoprotein metabolism dysregulation in lysosomal acid lipase deficiency a) The liver secretes VLDL, which is lipolyzed in the periphery by LPL and HL to generate LDL NPC2 LPL NPC1 LDLR ABCA1 PMC6207572__F1 Dual functions of IFITM3 in the innate antiviral immune response STAT1 STAT2 IFITM3 IRF3 PMC1359062__F1 Ciliated cell differentiation into goblet cells requires 2 signals EGF TGFA EGFR PMC12105221__F3 Several classical mechanisms of EDCs that contribute to the development of endometriosis [79, 80] MMP2 AHR FOXP3 MMP9 PMC12105221__F2 Estrogenoids contribute to the development of uterine fibroids through alterations in epigenetic pathways [17, 56] ME3 GDF10 IGFBP5 tmp_locus_29 PMC8964223__F3 Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in Their Role and Management in Crohn's Disease FGF8A FGF7A CYP7A1 PMC11704687__F6 Signaling pathway model LATS1 BIRC5 LATS2 DCLK1 AREG PMC5644625__F1 Activation of the complement system C6 C7 HEL-S-62p C2 C1S C9 VTN C4A C4B_2 PMC3876738__F2 Therapeutic targets in cancer cell metabolism and autophagy ATG10 ATG3 ATG12 MTOR ATG5 PMC12105221__F4 How BPA contributes to the development of endometrial hyperplasia, endometrial cancer and infertility through DNA methylation alterations [12, 100] DNMT3B MUC1 LCN2 HAND2 FBLN2 RET MBD2 PMC8358862__F8 Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy NLRP3 KEAP1 TXNIP TLR4 SHH SMO PMC8313886__F2 N6-methyladenosine methyltransferases: functions, regulation, and clinical potential HMBOX1 PERP AFF4 PRDM2 SOX2 PTEN MTOR YY1 MYC DROSHA CTNNB1 PHLPP2 FOXO3A WTAP METTL14 MCM5 TRIM11 MCM6 MDM2 CCND1 PMC2040891__F5 UVB acts at both the switch and the switched pathway to trigger UV-induced apoptosis BAX MDM2 PMC3652575__F2 Activation pathway of pDCs responding to viral nucleic acids and negative regulation of the pDC function by surface receptors CD80 BTK TLR9 IRAK1 IRF7 TLR7 IL6 TRAF6 IRAK4 MYD88 PMC6543964__F2 Complement cascade and complement regulatory proteins (CRP) HEL-S-62p CFI CFD CFH THBD CP PMC7699880__F2 Leptin–melanocortin pathway SIM1 LEPR MC4R ARC PMC7071158__F3 Leptin-induced pathways STAT3 FOXO1 LEPR POMC NPY SOCS3 AgRP MTOR PMC8470674__F1 Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives NANP GNE CMAS NANS PMC8464874__F6 L-Plastin Phosphorylation: Possible Regulation by a TNFR1 Signaling Cascade in Osteoclasts LPL RHO SRC TRAF6 PMC3670280__F3 STAT1 as a central mediator of IFNG and TLR4 signal integration in vascular dysfunction TLR4 IRF1 IRF3 IRF8 JAK1 TYK2 MYD88 PMC6405305__F4 Network modeling of the epithelial-to-mesenchymal transition (EMT) TF SHH PMC1940036__F6 Wnt/Axin1/Beta-Catenin Signaling Regulates Asymmetric Nodal Activation, Elaboration, and Concordance of CNS Asymmetries AXIN1 NODAL PITX2 PMC6405305__F1 Towards control of cellular decision-making networks in the epithelial-to-mesenchymal transition CDH2 TGFBR2 BACH1 HMGA2 GRB2 MYC TGFBR1 PMC3960348__F2 Schematic overview of the mTOR signaling pathway with the target position of drugs TSC2 TSC1 PTEN MTOR PMC3960348__F1 Schematic overview of the mTOR signaling pathway with the most important factors and their action RHEB STAT3 TSC2 TSC1 SGK1 ULK1 PTEN PMC4852160__F1 Adenosine monophosphate-activated protein kinase (AMPK) activators for the prevention, treatment and potential reversal of pathological pain TSC2 NGF TSC1 IL6 EIF4E PMC3148828__F4 KEGG pathway: cell cycle ATR CDC20 CDK7 PCNA SMAD4 CDK2 ATM SKP2 PMC9562239__F1 Advances in Biomarkers and Endogenous Regulation of Breast Cancer Stem Cells CCND3 APC GSK3B NRP2 PTEN USP37 RHO CTNNB1 CDH11 SUFU PTCH1 SHH B4GALT5 KLF5 SMO PMC3046919__F7 Proposed model of the process of A20 SMAD2 SMAD4 PMC7565722__F6 TRAIL of oncogenes to apoptosis BAX ROS1 ROMO1 PMC10459989__F5 Schematic diagram of the plant hormone signal transduction pathway and its correlation with DEGs in response to B ERF RPS5 RPS2 EBP BAK1 PMC6798329__F6 Activation of AhR pathway by mycotoxins (Myctx) AIP AHR CYP1A1 PMC4914023__F1 Melanosome biogenesis is a typical model for studying LRO biogenesis RAB32 TYRP1 RAB9A RAB38 VAMP7 PMC7961911__F5 Network/pathway analyses: KDM1A is directly linked to the androgen receptor signaling pathway (green) and is indirectly linked to the immune response, DNA damage response, and cancer cell cycle pathway, among others CDC2 RAN ATR PCNA DPY30 CLSPN BLM TXN FOXM1 KDM1A TFRC CCNE1 CDC45 CHEK2 ATM MCM2 HDAC2 HMGB2 PMC10526140__F4 Understanding the Clinical Use of Levosimendan and Perspectives on its Future in Oncology ATR BRCA1 AMT BRCA2 PTEN MYC PMC10296711__F8 Schematic illustration of the TLR/IL1/IRAK/NFKB inflammatory signaling pathway axis MAP3K7IP1 IRAK3 RELA IRAK1 IRAK2 IL1A TRAF6 IRAK4 MYD88 PMC10296711__F5 Schematic illustration of the activation process of TLR receptors and their downstream signaling molecules upon activation forming the TLR-MYD88-IRAK1/4-TRAF6-NFKB/IRF or TLR3/TLR4-TRIF-IRF/NFKB signaling pathways CD80 LTA TLR9 IRAK1 TLR5 IL6 TNF TRAF6 CCL2 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 TLR10 PMC6482253__F1 Eukaryotic cell metabolism TSC2 TSC1 MFN1 MFN2 PMC549180__F2 ErbB signaling pathway BAD PTEN GRB2 MTOR SHE CCND1 PMC4480226__F1 Immune Responses to HCV and Other Hepatitis Viruses TBK1 MAVS TLR3 PDC IRF3 TLR7 TRAF3 PMC10531306__F2 Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism—A Favorable Backdoor Mechanism for the GHR Function IGF1 SRC GHR PMC11881607__F3 Deubiquitinases functioning in asthma pathology USP25 BARD1 NLRP3 USP4 JUNB TRAF3 USP21 TNF CYLD HDAC2 BRCC3 GATA3 PMC11881607__F2 E3 ubiquitin ligases inhibit asthma pathology SOCS1 TRPM2 NLRP3 ITCH CUL5 CUL4B IL33 FBXL19 IL1B GATA3 TRIM21 PMC3149764__F3 Emerging roles of JAK–STAT signaling pathways in adipocytes IFNG OSM PRL LIF PMC11881607__F1 E3 ubiquitin ligases promote asthma pathology IL25 MID1 CBX4 AMFR PMC6704453__F8 The Mb maturation process AARSD1 MB CDC37 HEL-S-94n PMC3380732__F7 Analysis of the cell cycle pathway LMO2 NR1C1 PAX4 NFIB SREBF2 CDKN2B CDK4 PMC9578007__F1 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis NR1H4 PPARG LEP SLC2A4 EGFR FGF21 ACACA INS CCL2 XBP1 TLR4 IL18 PPARGC1A AHNAK HEL-S-44 HMGB1 FASN IL17A TNF FGF2 CCL24 NR1C1 LIPE CPT1A SIRT1 PMC8721856__F2 Research progress on SLC7A11 in the regulation of cystine/cysteine metabolism in tumors SLC3A2 ATF3 BRD4 KEAP1 BAP1 SLC7A11 ATF4 EIF2A PMC9086235__F1 Interaction Between Autophagy and JAK/STAT3 Signaling Pathway in Tumors IL-21 IFNG JAK3 JAK1 TYK2 PMC7707178__F2 Sterol regulatory element-binding protein Sre1 regulates carotenogenesis in the red yeast Xanthophyllomyces dendrorhous IPP MVD MVK PMC2831042__F7 Proposed model of neurite outgrowth pathway in postnatal SVZ/RMS-derived neurons CDC42 RAC1 PMC11635660__F2 Transcriptomic analysis of dietary G ACLY CDO1 INSIG1 PMC4837953__F2 Characteristics of the interplay among RIPPLY2, TBX6, and MESP2 and their relation in the notch signaling pathway and L/R axis determination RIPPLY2 MESP2 TBX6 NODAL PMC3638770__F4 Two major pathways to apoptosis BAX BAD ATM FADD PMC6311798__F1 Red arrowhead represents inhibition IGF1 INSR SMAD4 PTEN PDK2 INS PMC11765430__F7 Schematic diagram illustrating the molecular mechanism by which lactate promotes granulosa cell autophagy via the HIF-1A/BNIP3/Beclin-1 signaling pathway HEL-S-133P BNIP3 BCL2 PMC4423646__F1 Ischemia/ reperfusion-induced and sepsis-induced endothelial dysfunction is initiated by increased amounts of reactive oxygen species BAX STAT1 IRF1 PMC4515436__F4 Short range signalling between the germline stem cells and their niche, which consists of the hub cells and the cyst stem cells EGFR SMO GSC PMC9700707__F6 In silico and in vitro analysis of microRNAs with therapeutic potential in atherosclerosis NPC2 LPL CD36 PLTP PMC8471358__F3A Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives IGF1 IGF1R MTOR KRAS PMC6442489__F7 Schematic illustration of SAA attenuating kidney oxidative stress in 5/6Nx rats KEAP1 NOX4 PMC2682636__F4 The comorbidity of HIV-associated neurocognitive disorders and Alzheimer’s disease: a foreseeable medical challenge in post-HAART era IDE CD36 CCR5 PMC8637759__F9 Pharmacological Inhibition of HMGB1 Prevents Muscle Wasting HMGB1 IL6 TNF PMC4443741__F4 CD44 interferes with apoptosis resistance in HSC/LIC CD44 MMP7 HBEGF BAD HGF ERBB4 HAS1 HAS3 HAS2 CDC37 GRB2 PMC9344092__F2 Phagocytic microglia and macrophages in brain injury and repair CD36 IL33 ARG1 PMC5450035__F1 Neuroimmune interface and the role of glia in the pain response IFNG IL1R1 HMGB1 CCR2 MTOR CCL2 TNF PMC6442705__F7 Mechanistic illustration of the effect of alcohol on the dysregulation of genes involving several metabolic pathways leading to alterations in serum metabolomic profiles CYP8B1 FGF21 CTH SULT1E1 FGF8A NR2A1 CYP7A1 SULT2A1 GCA pcap HEL-S-61p CYP7B1 MTR MAT1A CYP27A1 PMC9497316__F8 Proteomic Analysis of Retinal Mitochondria-Associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-Term Diabetes HEL-S-101 CASP9 TGFBI CLCN3 CRYGD CRYBB3 CRYBA2 KDR MERTK CP PMC8427189__F2 Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth CRH POMC TNF PMC6907743__F1 Autophagy during viral infection — a double-edged sword TBK1 CGAS TRIM32 MAVS STAT2 ULK1 IRF9 TUFM TLR9 IRF3 IRS1 MYD88 STAT1 ATG12 TLR3 FOXO3A SENP2 TLR7 EIF2A PMC9588458__F7 Working model of hyperglycemia in DCM BAX BCL2 MAPK10 ATF4 PMC5488809__F2 Cancer metabolism as a central driving force of glioma pathogenesis PIK3CA TERT PTEN PMC6907743__F3 Autophagy during viral infection — a double-edged sword TBK1 EDEM1 ULK1 SNAP29 UVRAG IRGM TUFM STX17 IRS1 GBF1 TSC2 ATG3 ATG12 HEL-S-69p EIF2A ATG5 PMC8287779__F2 Exosomes in lung cancer metastasis and clinical applications: an updated review STAT3 MORC2 MMP9 PMC8796122__F2 Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification APC MYH9 RELA GRB2 SRC REL CTNNB1 PMC7436330__F1 Red arrow shows the classical pathway of LPS-mediated activation of TLR4 that further leads to pyroptosis and releases of IL-1B and IL-18 GSDMD IL16 TLR4 PMC5635916__F6 Model for how cytosine deamination, base excision repair, and Mlh1-Mlh3 cleavage cooperate to cause R-loop–induced CAG repeat fragility and contractions MLH3 RAD1 PMC1975829__F1 Viral infections: beneficial role of eosinophils EPX ITGAM TLR7 PMC8253640__F2 Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis MB MTOR SESN2 PMC9387558__F1 Hormone supply to the pituitary gland: A comprehensive investigation of female-related tumors (Review) IGF1 GHRH GHR SST PMC3520616__F1 Upstream events in BCR signaling SYK BTK BCR PLCG2 LYN PMC3368902__F1 Postprandial Regulation of Hepatic MicroRNAs Predicted to Target the Insulin Pathway in Rainbow Trout PTEN MTOR IRS1 PMC6115711__F3 SUMOylation system and TGFB signaling interplay PIAS1 SMAD4 SMO ZEB2 SMURF2 PMC9576590__F5 Senescence-associated secretory phenotype (SASP) ATM MTOR PMC5622153__F3 BACE1-dependent NRG1/ErbB4 signaling pathway involving in the pathogenies of schizophrenia EGF NRG1 ERBB4 BACE1 NRG3 PMC6207918__F10 TGFB/ALK1 signaling at the BBB and regulation of the Slco1a4 gene SMAD1 DKFZp781O1323 SMAD4 PMC5622153__F2 Neuregulins proteolytic cleavage pattern by BACE1 EGF ADAM17 ERBB4 BACE1 NRG3 PMC6333596__F2 Sonic hedgehog signaling pathway SUFU PTCH1 SOX2 SHH SMO CCND1 PMC3137255__F2 A simplified model for Hh signaling in mammalian cells KIF7 BOC SUFU SMO PMC4728015__F4 Galactose-1 phosphate uridylyltransferase (GalT) gene: a novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts HEL-S-19 IGF1 PTEN PMC6611727__F3 Caspases in cell death, inflammation and disease BAX CASP9 CASP8 TRADD MLKL TAB3 TNF RIPK3 GSDMD ZBP1 NLRP3 CASP3 RIPK1 TRAF2 FADD PMC2933570__F1 Coordinated upregulation of cytoprotective genes occurs as a result of Nrf2 activation GCLM GCLC PRX PMC3225028__F2 WT1/EGR1-mediated Control of STIM1 Expression and Function in Cancer Cells WT1 EGR1 STIM1 PMC9411204__F4 Proposed biosynthetic pathway of triptonide (2) from 14-hydroxy-dehydroabietadiene (5) in S. cerevisiae H1-5 HIST1H1E PMC3205852__F10 Schematic illustrating the potential role of integrin B3 (ITGB3) in ROS-induced migration and invasion of colorectal cancer cells GRB2 SRC HEL-S-44 PMC11491057__F3 Epigenetic modulation and tumor immune efficacy CD40 CD80 EZH2 CCL5 MYC TBX21 HLA-A PMC11491057__F2 Tumor immune efficacy by the cGAS-STING pathway CD80 APC PMC4489259__F2 Output of a fictitious combination of gene expression and mutations in version of the Calcium signaling pathway modified for illustrating the examples PLCD3 PLN CACNA1A PHKA1 CALML6 CHRM1 EGFR TRPC1 CHRNA7 BST1 GNAL ATP2A1 MYLK PLCE1 PLCG1 PLCB1 GNA11 CAMK4 ADCY1 PMC11491057__F4 Illustrates the mechanisms of metabolic regulation in tumor immune evasion CD36 MYC KRAS CD47 PMC9037156__F9 Icariin: A Potential Molecule for Treatment of Knee Osteoarthritis HBEGF EGFR TNF PMC8255141__F4 Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene TREM1 CASP5 TLR4 TREML1 TNF IL1B MYD88 PMC10844364__F4 Novel acylations act as significant regulators in HCC metastasis TFAM AK2 CS IL6 ITGB3 PMC8869096__F1 Relevance of miR-223 as Potential Diagnostic and Prognostic Markers in Cancer MLST8 IL10 NLRP3 IL18 MTOR DEPTOR PMC9356732__F4 Comparative Genomics of the Waterfowl Innate Immune System TH SPOP IL12A ATG12 MAPK13 MAK NFKBIA CHUK CXCL10 TRAF2 PMC9356732__F3 Comparative Genomics of the Waterfowl Innate Immune System TF CTSK TANK CHUK APP FOS PMC6721756__F7 Role of distinct STAT2 and/or IRF9-dependent pathways in the regulation of distinct subset of antiviral and immunoregulatory genes in response to IFNB and TNF STAT1 JAK1 TYK2 PMC8844014__F8 Alpha-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal PLN TNC HRC BCR PI3 MCU PMC10844364__F1 Main functions and metabolic origins of novel acylations MLST8 TMOD3 PHF5A CDK2 PMC10844364__F2 Novel acylations participate in head and neck cancer metastasis TF HDAC3 TG RAB27A EGFR ZDHHC13 PMC10179672__F4 Ligands, receptors, and transcriptional regulators of Hedgehog signaling pathway SUFU SMO PMC10179672__F5 Key components involved in the regulation of activation/inactivation of the canonical or Wnt/Beta-catenin pathway APC CTNNB1 PMC4562871__F1 Conceptual barriers to understanding physical barriers IL13 TNF PMC6935754__F1 Hypotheses for the accumulation of amyloidB42 and tau pathology linked to cognitive impairment and epileptogenesis in TLE BACE1 APP ADAM10 MTOR PMC4522091__F1 Simulation of metabolic flux changes in the central metabolism of the redox reaction manipulated strains HEL-S-162eP LDHD CIT PMC5974030__F7 Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice DCX GFAP NEUROG2 HEY2 PTCH1 NEUROG1 SOX2 SHH PAX6 PMC6975221__F5 KEGG pathway of cardiac muscle contraction (a) and PI3K-Akt signaling pathway (b) RYR2 TNC BAD C1S PTEN MTOR MYC TRDN RHEB HRC CASQ2 RXRA MDM2 PMC8187902__F2 Breast Cancer Resistance to Cyclin-Dependent Kinases 4/6 Inhibitors: Intricacy of the Molecular Mechanisms CDC2 APC PTEN VEGFA CCNH RB1 FZR1 CDK6 CDK7 CCNE1 WEE1 CDK2 MDM2 CDK4 PMC8187902__F3 Breast Cancer Resistance to Cyclin-Dependent Kinases 4/6 Inhibitors: Intricacy of the Molecular Mechanisms FOXA1 TFF1 CDK6 SP1 EGFR MAF PRB1 ERBB2 CDK2 MTOR CDK4 PMC9491322__F10 Organic acid metabolism in Chinese dwarf cherry [Cerasus humilis (Bge.) Sok.] is controlled by a complex gene regulatory network SI MDH2 PMC6039344__F1 IL-33 signaling CCL22 TGFB1 PCNA IL33 CDKN2B MTOR CCL2 FBXL19 IRAK4 MAPK3 MYD88 ABCG1 TMED1 MMP3 RETNLB CCL17 NOS2 JUN CSF2 CCL11 SELE IL13 IL1RL1 SIGIRR IL4 ARG1 FLG AREG IL6 TNF FOS CCL24 TSLP NFKB1 RELA TNFSF11 CCL20 PMC6945043__F1 Embryonic origin of the E blastomere and simplified diagram of the gene regulatory network for endomesoderm specification in C MED12 MED1 POP1 PMC4531144__F1 Schematic demonstration of PHB-mediated survival or apoptosis responses in multiple cellular compartments of different cell types and molecular mechanism involved PHB2 OPA1 PMC7689594__F6 Sub-network of hub genes related to the disease phenotype of chronic ITP JUN PRKACG SMC3 LMNA PMC4618091__F2 Scheme of biosynthesis of bile acids and of traditional steroidogenesis CYP21A2 CYP17A1 CYP11B2 CYP11A1 CYP7A1 HSD3B7 CYP7B1 CYP27A1 PMC8507042__F1 Metabolic reprogramming in epithelial ovarian cancer STAT3 PHGDH HEL-S-68p F2 HK2 HEL-S-162eP PMC7042886__F2 APP and ΑB Metabolism IDE APP HEL-S-70p PMC8910500__F1 Signal Transduction during Metabolic and Inflammatory Reprogramming in Pulmonary Vascular Remodeling EGFR PDK3 FGF2 PMC8955121__F6 Rotavirus-Mediated Suppression of miRNA-192 Family and miRNA-181a Activates Wnt/Beta-Catenin Signaling Pathway: An In Vitro Study CCND2 SMAD4 LRP6 CTNNB1 PMC6095619__F1 cGAS and STING: At the intersection of DNA and RNA virus-sensing networks TBK1 CGAS IRF3 PMC7709568__F5 Pathway enrichment analysis of (A) significantly higher expressed genes and (B) significantly lower expressed genes in T47D cells after glucose deprivation POLD3 RFC4 RFC2 SLC5A3 CCNA2 TYMS SKP2 PLK1 FANCA ERN1 FANCD2 HEL-S-99n HMOX1 FANCG DNAJC3 DKFZp762B153 CCNE1 DNAJB9 RPA3 MAF SMC2 POLE TRIB3 MSH6 ESPL1 RAD51 POLE2 H2AX GCLM PRIM2 GSTM5 RBBP8 ATF3 BARD1 GPX2 POLA1 POLA2 MCM10 CDC45 MCM3 MCM5 CDK2 MCM6 MCM2 HEL-75 SLC3A2 BRIP1 FGF13 ATR PCNA CDC6 BRCA2 DHFR CLSPN SLC7A11 SQSTM1 FOXM1 CDKN2C CHEK2 TTK CCNB1 CCND1 TOP2A DBF4 HMGB1 FEN1 RRM1 RRM2 HEL-S-89n GMNN RBL1 PTTG1 FTH1 CCNE2 PKMYT1 FTL HEL-S-125m CHEK1 DDIT3 RFC3 RMI1 PMC9583871__F1 Anti-cancer immune responses to DNA damage response inhibitors: Molecular mechanisms and progress toward clinical translation CDC2 TBK1 ATR CGAS H2AX IRF1 IRF3 IRF7 TNF TRAF6 STAT1 WEE1 CDK2 ATM PMC2736391__F2 Simplified model of the leptin signaling pathway TRH MC4R MC3R PC NPY AgRP BDNF PMC8294160__F4 Oxyresveratrol Modulates Genes Associated with Apoptosis, Cell Cycle Control and DNA Repair in MCF-7 Cells MOS GEM STOM PMC8793120__F1 BMI1 in the Initiation, Progression, and Treatment of Hepatocellular Carcinoma BMI1 CTNNB1 PMC7600646__F1 Role of dietary flavonoids in the regulation of the Nrf2/ARE pathway in normal cells KEAP1 PMC8877312__F3 Induced Expression of BPV E4 Gene in Equine Adult Dermal Fibroblast Cells as a Potential Model of Skin Sarcoid-like Neoplasia STAG2 DBF4 CDC20 PCNA CDC6 STAG1 SMAD2 SMC3 SMAD4 CYC1 MYT1 ORC3 SKP2 ORC2 CDK6 CDK7 E2F4 CDC45 CDK2 MDM2 MCM2 CDK4 PMC8948490__F1 Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Pathway in Osteoblasts CDC42 NF1 RHO RUNX2 PMC5548104__F4 Reelin-LIS1-tubulins pathway TUBA1A DCX VAMP2 TUBA8 NDE1 WDR62 TUBG1 TUBB NDEL1 PMC3003620__F1 PI3K/Akt signaling pathway RHEB RPS6 TSC1 MTOR PMC3147278__F3 Cross-talk between TLR4 and IL-1 signaling pathways IL1R2 IL1R1 TLR4 IL1A IL6 TRAF6 PMC5548104__F3 The PI3K-AKT-mTOR signaling pathway PHF20 RPS6 PIK3CA BAD STK11 EIF4EBP1 PIK3R2 EZH2 PTEN MTOR MYC VHL EIF4E RHEB TSC2 TSC1 CDKN1A NF1 PDPK1 CDKN1B FGFR3 MDM2 CCND1 PMC4169452__F2 An Integrated Ontology Resource to Explore and Study Host-Virus Relationships TH MAVS TRIM25 PMC7658045__F7 Distinct cation gradients power cholesterol transport at different key points in the Hedgehog signaling pathway PTCH1 DISP1 SHH SMO PMC8931408__F2 Innate Immune Evasion by Human Respiratory Syncytial Virus TBK1 MAVS STAT2 IRF9 IRF3 SOCS3 TRAF3 TRAF6 MYD88 STAT1 TRIM25 NLRP3 TLR3 IFNAR1 NOD2 OASL TLR7 ISG15 PMC3844930__F1 Defining mitochondrial dynamics RHEB BAX FIS1 OPA1 MFN1 MFN2 BNIP3 NRF1 MFF HDAC6 PMC9494868__F7 TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NFKB signaling pathway PRL IGFBP1 TOP2A PMC11842293__F7 Mechanisms by which OPC mitigates LPS-induced renal tubular injury BAX TNF PMC7865281__F4 Notch-dependent signaling events and signaling crosstalk during the differentiation of MSCs towards osteocytes MSC RUNX2 PMC3844930__F5 Mitophagy pathways RHEB PINK1 OPA1 MFN2 BNIP3 PMC8131909__F1 Molecular-targeted therapy toward precision medicine for gastrointestinal caner: Current progress and challenges EGFR SMAD2 APC SMAD4 MTOR TGFBR1 CTNNB1 BTK CDK6 ALK DKK1 SMO CDK4 PMC8581356__F1 Immune Evasion Mechanism and AXL SOCS1 CXCR6 AXL CCL3 CCL4 SOCS3 CCL5 CTLA4 FOXP3 CCL2 PMC7060614__F1 Alterations of the propionate pathway in times of acute metabolic decompensation NAGS MCC PCCA CTH OTC MMADHC MCEE PMC2645295__F1 Airway Smooth Muscle Cell as an Inflammatory Cell TRADD JAK1 TRAF2 TYK2 PMC2753863__F1 Examination of Association of Genes in the Serotonin System to Autism TPH1 AANAT TPH2 DDC PMC7780675__F8 Schematic illustrating the role of MGMT in HR signaling in NPC cells RAD51 BRCA1 BRCA2 MGMT PMC8056677__F7 Calvin (left) and C4-Dicarboxylic acid cycle (right) in S HEL107 RPE HEL-S-162eP PMC11874147__F3 FAO signaling pathway and ferroptosis in BC IFNG STAT3 FAS GPX4 FACL4 FADS2 SLC7A11 ZEB2 MYC FADS1 PMC11874147__F2 Dysregulation of lipid synthesis and related pro-oncogenic signaling pathways involved in BC development ACLY FAS HMGCR EGFR ABCA1 PMC4071059__F3 Molecular Signals Elicited by GPCR Agonists in Hypertension, Cardiovascular Remodeling: Are MMPs and ADAMs Elusive Therapeutic Targets? RHEB TBR1 EEF2K TSC2 SMAD2 GSK3B SMAD6 SMAD4 GRB2 MTOR GATA4 EIF4E PMC7979820__F2 Epigenetic mechanisms in breast cancer therapy and resistance DKK3 PTCH1 GSK3B SHH CTNNB1 PMC7979820__F4 Epigenetic mechanisms in breast cancer therapy and resistance FOXA1 ARID1A KMT2C KDM5B MLL2 EZH2 PMC2909599__F1 GLP-1 acts by means of the GLP-1-R to stimulate adenylyl cyclase (AC), and thereby cAMP production, and to activate the cAMP-binding proteins PKA and Epac IGF1 FOXO1 EGFR BTC FOXA2 IGF1R GRB2 PMC11912584__F1 HRS-4642 can inhibit KRAS G12D binding to SOS or RAF1 and inhibit downstream MEK-ERK signaling pathways KRAS: Kirsten rat sarcoma viral oncogene homologue SOS: Guanine nucleotide exchange factors (GEFs, e CDC42 TBK1 EGF BAD TIAM1 MTOR KRAS PMC8571914__F2 S1P Signaling Pathways in Pathogenesis of Type 2 Diabetes SPNS2 RHO TRAF2 PMC8359440__F5 Enantiomer‐specific pharmacokinetics of D,L‐3‐hydroxybutyrate: Implications for the treatment of multiple acyl‐CoA dehydrogenase deficiency ACLY HMGCL AACS PMC4874878__F6 Altogether, our findings are summarized in CYP7A1 FASN IL18 TNF IL1B PMC6826160__F5 ROS‐dependent priming and activation of the intrinsic cell death pathway CASP9 OPA1 PMC4755889__F3 Interconnections between the Hippo and RB/E2F pathways LATS1 CDC2 LATS2 POLA1 RBBP4 LIN52 CDC6 MCM3 MCM6 RUNX2 PMC10813042__F3 Antioxidant mechanism of estrodiol EGFR SRC PMC4755889__F1 Regulation of transcription by YAP/TAZ transcriptional co-factors and the regulation of YAP/TAZ activity in mammalian cells PAX3 EGFR SMAD2 APC TBX5 AREG ARHA RUNX2 CTNNB1 LATS1 BIRC5 LATS2 AMOT SHH MCM6 NF2 PMC7400965__F2 Difference between SHARPIN presence and absence in regulating the NFKB signaling pathway SHARPIN TRADD TRAF2 FADD PMC6358228__F1 Canonical pathway network analysis TRH TGFB1 PCSK1 PRL PCSK2 GHRH CSHL1 VEGFA PMC7400965__F3 SHARPIN regulates multiple signaling pathways in tumorigenesis PAX3 SHARPIN PTEN MDM2 SOX10 PMC4152724__F2 Immunoregulatory molecules are master regulators of inflammation during the immune response ZAP70 IFNG STAT3 STAT1 CD80 APC GADD45A PMC4152724__F1 Immunoregulatory molecules are master regulators of inflammation during the immune response IFNG CD80 APC PMC6351787__F5 Hexosamine pathway OGA C6 OGT C2 PMC9132697__F2 Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle IGF1 FOXO3A MARF1 MTOR PMC5892012__F1 TERT levels affect EBV latent/lytic status BATF TERT NOTCH2 PMC5448608__F5 Schema of BTB and CNC homology 2 (BACH2) interaction in the nuclear factor‐KB (NFKB) signaling pathway TAB3 TRAF6 PMC5834263__F11 Sensitization of multidrug-resistant cancer cells to Hsp90 inhibitors by NSAIDs-induced apoptotic and autophagic cell death STAT3 HSF1 MTOR PMC3432834__F2 Two NFKB activation pathways induced by RANK, CD40, and LtB R signaling CD40 LTBR RELA RELB TRAF3 TRAF6 TRAF2 PMC10153643__F2 Thermogenic adipose tissue in lipid metabolism and atherosclerotic cardiovascular disease: lessons from studies in mice and humans PCSK9 LPL LDLR PMC7291112__F1 Roles of gga-miRNAs in host response to infectious bursal disease virus (IBDV) infection IRF2 TANK SOCS3 SOCS6 PMC7917704__F6 HMGA2 is regulated by the RAF kinase inhibitor protein (RKIP) pathway HMGA2 CCL5 SDC2 PMC7917704__F5 HMGA2 induces EMT by activation of different signaling transducers STAT3 HMGA2 TGFBR3 HAS2 GRB2 MTOR NOTCH2 NOTCH3 PMC3110682__F1 Hypothesized mechanisms of physical activity in colon cancer IGF1 COX2 APC PMC6216001__F6 Network generation of CDK1, YWHAZ and PRKDC based on significantly differential genes found between cells with PAX2 over-expression and those that lack that over-expression AURKA SYK ATXN10 HELLS GAPVD1 XRN1 VPS37C PPP1R2 IGF1R ATAD1 MYO5C CLK1 RPS6KA6 RB1 PYGL SLIT2 KIF24 TUBA4A CSNK1G1 ATM CASK SMC2 PSMD4 CDC2 HEL-S-43 MYO9A PKP2 HEL-S-84 TMOD3 BMP2K EIF3E PRKDC ADK RAB18 SPTLC1 RPS6KA3 IKBIP GJA1 YWHAZ PMC12187357__F1 Microenvironment drivers of the EMT CCL18 HIF1A ZEB2 CCL5 TNF PMC7982393__F1 Physiological and pathological functions of the RAS ATR ACE2 PMC6277881__F4 Subolesin/Akirin function in immune response pathways TNF PMC7268348__F7 MYC and HIF-1 regulate glucose metabolism HEL-S-133P HEL-S-162eP MYC PMC12187357__F5 Signaling pathways responsible for EMT-induced drug resistance in HCC HRAS EGF EGFR SMAD2 SMAD4 MTOR CTNNB1 PMC12187357__F4 miRNAs cause EMT-induced drug resistance CXCL12 APC PTEN EP300 CXCR4 CTNNB1 PMC4426090__F6 Proteomic Profiling of a Biomimetic Drug Delivery Platform CDC42 ARHH VASP ITGA4 THY1 ARHA JAM3 RAC1 CD99 TEC JAM2 ITGAM ERMN CXCR4 PMC1557825__F4 Ordering and correlation network diagrams for the significant pathways CYP24A1 HEL-S-53e TBXA2R AKR1B10 CYP27B1 ALDH2 PTGS1 PTGFR EPHX2 CYP26A1 PTGER2 PTGER3 PTGS2 ALDH3A2 PTGIS EPHX1 ALDH7A1 PTGER1 PLCB1 CYP2J2 ALDH9A1 ALDH1A2 PTGES PTGER4 PTGIR PMC12187357__F3 NFKB causes EMT-induced drug resistance ZEB2 TNF TWIST1 NOTCH1 PMC4492816__F6 Definition of the early fracture healing pathwaySchematic detailing the role of the early inflammatory pathway in fracture healing OSM CCR2 CCL2 TNF PMC9102269__F9 Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver PGP RAB11A EEA1 ABCB1 PMC9695947__F1 Farnesoid X Receptor as a Master Regulator of Hepatotoxicity ABCG8 ABCG5 CYP8B1 CYP7A1 CYP7B1 CYP3A4 CYP27A1 PMC4638128__F2 Microhomology-mediated end joining: a back-up survival mechanism or dedicated pathway? LIG1 POLE PARP1 PMC8290460__F1 MicroRNA-129 in cancer and non-cancerous diseases (Review) Nbla10236 CBX1 HEL-S-1 MTOR PMC4638128__F4 Microhomology-mediated end joining: a back-up survival mechanism or dedicated pathway? RAD51 POLE PMC3792734__F1 Main biosynthetic pathway of saturated and monounsaturated fatty acids SCD FASN ELOVL6 PMC3863344__F2 Downstream targets of p38 MAPK MAX STAT1 RARA HMGN1 MYC PAX6 PMC2930200__F1 Molecular machinery of myelin gene transcription in Schwann cells MPZ MBP SOX2 SOX10 PMC10376943__F4 FGF1 Protects MCF-7 Cells against Taltobulin through Both the MEKs/ERKs and PI3K/AKT Signaling Pathway EGF EGFR MTOR PMC3579281__F1 Simplified overview of inflammation-orchestrated signal transduction that induces pro-tumourigenic responses in glioblastoma STAT3 EGF CXCR1 EGFR IL8RB PMC8107475__F1 Abscisic Acid as an Emerging Modulator of the Responses of Plants to Low Oxygen Conditions ERF SNRK ATE1 PMC6873535__F2 Effect of RAS signaling components on neural stem cell differentiation HRAS RAF1 NF1 BRAF PTPN11 PMC6873535__F1 RAS-ERK signaling pathway and associated disorders RAF1 SOS1 NF1 BRAF CS GRB2 PMC2904042__F2 Concurrent deregulation of the top five canonical pathways in retinoblastoma (RB) tumors FANCD2 MRE11A BRCA1 ATM PMC4626012__F1 Role of epidermal growth factor receptor in acute and chronic kidney injury HBEGF EGFR MTOR SRC PMC7218232__F5 Metabolite and miRNA changes associated with 3R4F CS-induced immune response SAT2 NOS2 HEL60 SMS ACO2 SRM MPEG1 OTC ARG1 HEL-S-26 ARG2 PMC8864926__F1 Metabolic engineering of Escherichia coli for efficient biosynthesis of butyl acetate HBD ATF1 PMC3109859__F6 Finding Homes for Orphan Cytochrome P450s: CYP4V2 and CYP4F22 in Disease States ALOX12B CYP4F22 ALOXE3 PMC6139646__F6 Metabolic pathways impacted by PEPCK in the small intestine of mice MAL CIT PMC8126328__F1 G-Protein-coupled Estrogen Receptor 1 Agonist G-1 Perturbs Sunitinib Resistance-related Phosphoproteomic Signatures in Renal Cell Carcinoma CSF1 RAF1 EPHA2 PXN CRTC2 ATF2 FLNA PRKAA1 GRB10 PRKCA AKT1S1 AAG1 SRC ARHGAP35 FXR2 NCK1 FLNB RAB14 LRRFIP2 SET HEL114 TSC2 EIF4G1 PRKCI RICTOR TSC1 PAK1 SND1 NCL TH GIGYF2 EGFR PAK4 PPP2CA MTOR RPLP2 MYLK PRKCE MYH9 TLN1 PPP2R5D HSP90AB1 RPTOR RPS6 CAV2 JUN ANXA1 ACTN4 EPN1 MYL12A MAP2K2 PMC11506648__F6 AREG’s role in ESCC-MSC interactions EGFR MSC FAP AREG PMC8869630__F1 Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response TBK1 CGAS MAVS STAT2 MLKL IRF9 RNASEL IRF3 IRF7 TRAF3 TRAF6 RIPK3 STAT1 ZBP1 IFNAR2 IFNAR1 JAK1 TYK2 PMC4427618__F2 Coordination of developmental signalling pathways by USP9X EGF RICTOR SMURF1 ITCH MIB1 SMAD4 MTOR USP9X PMC8082835__F7 Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness GLUD1 GOT2 GPT2 GLS2 HEL-S-26 PMC8678479__F2 Pyroptosis: A New Insight Into Eye Disease Therapy NLRP3 KY TAB3 MYD88 PMC11033252__F6 Mechanisms of human NLRP6 inflammasome activation LTA GSDMD NLRP6 NLRP3 TLR4 TNF PMC11033252__F5 Mechanisms of human NLRP3 inflammasome activation and regulation IL1R1 GSDMD CASP8 MAVS NLRP3 S1PR2 TNF MYD88 PMC9117271__F1 Apoptotic signaling in VC HTRA2 BAX FAS ROCK1 TNF FADD PMC6906145__F1 Regulatory pathways for Arid5a under TLR4 signaling WWP1 STAT3 ARID5A TLR4 PMC10253673__F1 Potential mechanisms by which alcohol modulates Alzheimer’s disease (AD) pathology CDK5 BACE1 APP MTOR PMC7219141__F6 Hypothetical signalling pathway showing that dysfunctional TGFB network signalling regulates tissue fibrosis and may play a role in this PCOS-specific insulin resistance and its limited response to exercise training MTOR DCN IRS1 PMC3840259__F9 A summary schematic overview highlights the signaling pathway proposed in the present study COX1 HEL-S-11 PMC5501176__F4 Roles of Autophagy signaling pathway in cancer in type 2 diabetes RHEB TSC2 RICTOR STK11 TSC1 PDPK1 PMC8995973__F2 Pyroptosis by ncRNA: A Novel Research Direction NLRP1 GSDMD NLRP3 GSDMC GZMA GSDMB AIM2 DFNA5 TNF PMC8526866__F7 SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas RBBP7 EZH1 SUZ12 EED RBBP4 EZH2 ADCY1 PMC5501176__F3 Roles of SIRT1 signaling pathway in cancer in type 2 diabetes HDAC1 STK11 NFKB1 ATM PPARGC1A MTOR VEGFA SIRT1 PMC5501176__F2 Roles of mTOR signaling pathway in cancer in type 2 diabetes RHEB TSC2 TSC1 EIF4EBP1 PDPK1 IKBKB FASN HIF1A VEGFA SIRT1 PMC7374064__F6 Mechanical stretch regulates the expression of specific miRNA in extracellular vesicles released from lung epithelial cells PURA RB1 STAT3 NR1C1 COL1A2 MTDH AGO2 E2F3 PRDM1 NPM1 APP MYC PMC8403526__F2 SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance IFNG EPO IL2 PMC10536258__F3 Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke IL19 CXCL1 VEGFA PMC7264673__F1 Does High Cardiorespiratory Fitness Confer Some Protection Against Proinflammatory Responses After Infection by SARS‐CoV‐2? TAB3 IRAK1 TRAF6 IRAK4 IL1B MYD88 PMC10536258__F2 Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke GPR39 CNP MTOR PMC5868458__F3 Protein expression levels of healthy cerebral cortex cells mapped onto the GBM pathway map from the TCGA data set TSC2 INA GC PMC6275123__F1 Wnt/Beta-catenin pathway APC LRP6 PMC6275123__F3 The IGF2 signaling pathway BAD GSK3B PTEN IGF1R MDM2 GRB2 PDK2 MTOR IGF2 PMC9289111__F6 Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway PTEN FOXP3 MTOR PMC4483763__F5 Key signals mediating progenitor fate decisions during hepatogenesis HGF OSM NODAL PMC4037363__F3 Trafficking of endosomal Toll-like receptors IRF7 MYD88 PMC4901281__F7 In-depth comparative transcriptome analysis of intestines of red swamp crayfish, Procambarus clarkii, infected with WSSV IL10 CBL PIM1 EPO IL6 MYC PMC8427320__F3 Potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine CDH2 BAX PTEN HIF1A MTOR SRC PMC8269350__F1 Possible Link between SARS-CoV-2 Infection and Parkinson’s Disease: The Role of Toll-Like Receptor 4 TLR4 CD14 TRAF6 MYD88 PMC3082271__F5 NVN for Putative CHS-Mediated (CHS4) Medicarpin Biosynthesis.Nodes in the network resemble individual genes, and the connecting edges represent coexpressed links NEU1 MTR STS PMC8781535__F2 Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway Epithelium STAT1 IFNLR1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC7804410__F4 The selected miRNAs target genes in KF-Tx cells SYK CASP9 BAD RBL2 PTEN CD19 RAC1 INSR BCR PI3 RELA RXRA PRKCA NRAS YWHAZ PMC5840987__F1 Canonical and non-canonical Wnt signaling pathways.(Left) Unstimulated Wnt pathway results in constitutive Beta-catenin degradation JUN APC ROR2 GSK3B LRP5 LRP6 RYK ARHA RAC1 CTNNB1 PMC12042445__F8 Antioxidant and mitochondrial protective effects of EPS in PD BAX KEAP1 GCLC PMC3273421__F2 Myostatin and activin signaling in muscle SMAD2 SMAD4 PMC4817802__F4 Role of histone PTMs in DNA damage repair RNF25 RNF32 H2AX RNF31 HCGV RNF26 RNF2 BRCA1 RNF24 RNF38 RNF168 RNF34 RNF8 ATM RNF20 PMC1900132__F1 HCMV MIE promoter/enhancer and its cis-acting elements ERF SP1 YY1 PMC3947622__F1 Molecular programming of B cell memory BCR GC PMC8117345__F5 DNA Repair Repertoire of the Enigmatic Hydra ERCC1 XPA DDB2 DDB1 XPC PMC8797306__F2 Screening and verifying key genes with poor prognosis in colon cancer through bioinformatics analysis DBF4 CDK7 E2F4 APC SMC3 SMAD4 CDK2 SKP2 ORC2 PMC7448422__F7 Schematic diagram of the potential mechanism underlying the miR-590/LRP6/EMT axis in ESCC CDH2 LRP6 PMC7518857__F4 Hedgehog signalling is initiated at primary cilia GPR161 SAG PTCH1 SMO PMC7518857__F6 INPP5E regulates Hedgehog signalling via ciliary phosphoinositide metabolism GPR161 SMO INPP5E PMC9229940__F3 Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review VIT PMC7987878__F1 NRs promote tolerance increasing recognition and degradation of apoptotic cells CD36 ATG5 MERTK PMC9548020__F5 Treatment effects of the EGFR pathway drugs on head and neck cancer stem cells CD44 EGF EGFR GRB2 BDNF KRAS PMC5931986__F3 Nucleolar response to nuclear or nucleolar DNA damage POLL ATR CDC14B APC NPM1 POLI ATM PLK1 MDC1 NCL PMC3941198__F1 Milk lipid secretion: recent biomolecular aspects LPA DGAT1 GPAT4 ADFP PMC9259951__F2 Trends in the Contribution of Genetic Susceptibility Loci to Hyperuricemia and Gout and Associated Novel Mechanisms PNPLA3 NLRP3 TLR4 MLXIPL NFAT5 NR2A2 IGF1R GCKR ABCG2 SLC2A9 STC1 MLXIP PMC4361071__F1 Notch signaling pathway.(a) Schematic depiction of mammalian Notch receptors and DSL ligands EGF NOTCH2 NOTCH3 FURIN NOTCH1 PMC3514827__F1 Using components of the Vitamin D pathway to prevent/treat colon cancer NR1i1 ID2 DKK1 APC TCF4 ID1 CTNNB1 PMC7692253__F2 Identified B lymphocyte‐induced maturation protein‐1 (Blimp‐1) targets in mononuclear phagocytes (MNPs) SIGLEC1 NLRP12 HEL-S-2 PRDM1 MAFB CTSS IRF4 IRF8 CXCL10 CCL8 CCL2 IFNA1 PMC8129319__F5 WW45 inhibits breast cancer cell proliferation by the Hedgehog signaling pathway HHIP SHH SMO PMC4322894__F1 CXCL12 is highly expressed in tissues like lungs, liver, and bone marrow and is also secreted by tumor and stromal cells CDC42 CRK CXCL12 BAD PPA2 RHO CXCR4 CTNNB1 PMC16561__F6 The signaling pathway from the upstream protein-tyrosine kinases, Lyn/Syk/Btk, to cytokine gene expression through intermediate signaling proteins, PKCBI/JNK SYK BTK LYN PMC9632461__F6 CA regulates the mitochondrial quality and enhances the vitality of LMSCs PINK1 FIS1 MFN1 MFN2 PMC3605164__F2 New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic Beta-cells APC GSK3B AXIN1 LRP5 LRP6 CTNNB1 PMC8924518__F3 Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora NR1C1 LOX FGF21 CPT1A PMC2997801__F1 Positioning NFKB in multiple myeloma CD40 STAT3 LTBR IGF1 PI3 IGF1R TRAF3 CYLD TRAF2 PMC12028784__F7 This study TLR4 IL6 VCAM1 TNF PMC4905465__F6 Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome LY6D TGFBI CD27 ALB IFNG RARA RARB AHR UNG IL2 LY6K CEBPB PAX3 JUN CD2 LY6H TEX101 BLNK VEGFA LY6E TNF FOS NR1C1 HLA-C CD8A CD3E PMC8158527__F1 Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering SMAD1 DKFZp781O1323 SMAD2 BMP2 SP7 SMAD4 RUNX2 CTNNB1 PMC9157711__F2 Hepatitis B virus in development of hepatocellular carcinoma: Focus on covalently closed circular DNA FOXA1 STAT3 APOBEC3C PCNA DLL4 EZH2 APOBEC3B NOTCH1 MSL2 PMC3103888__F1 TIRs signaling pathway TBK1 TLR1 TLR3 IRAK1 TLR5 IRF3 TLR7 IL6 TLR10 MYD88 PMC2432088__F1 WNT SIGNALING PATHWAY: AGING GRACEFULLY AS A PROTECTIONIST? GSK3B RHO CTNNB1 PMC8180168__F1 Stem cells and exosomes: promising candidates for necrotizing enterocolitis therapy COX2 MUC2 TFF3 CTNNB1 PMC6284771__F8 Schematic model illustrating that miR-10b mediated function in osteogenic and adipogenic differentiation of hADSCs SMAD2 SMAD4 RUNX2 PMC7161552__F10 Modeling Neoadjuvant chemotherapy resistance in vitro increased NRP‐1 and HER2 expression and converted MCF7 breast cancer subtype EGFR NRP1 PTEN CCNB1 PMC6175900__F2 Evolutionarily selected pathway (ESP) map USP42 UBE4B PIK3CA NMT1 S100A8 PIK3R2 PIK3R1 TTI1 DYSF ZNF560 MAP9 FLNA CYLC2 ALB FAM47B RPL5 GRB10 NF1 FOXQ1 CEP135 POLE NOTCH1 HTT MAPK1 CLTCL1 NBEAL2 SPTBN1 CNTN1 MARK1 IRS1 ARHGEF17 UBE2D2 SAFB SPTAN1 WDR82 STK11 HSPG2 GIGYF2 THRAP3 IL2RA NCOA6 PRKCB CDK8 UBR5 PLCG1 HIPK2 USP4 EPHA3 NF2 MAP2K3 GOLIM4 CRB1 ACO2 POU4F2 CUL9 ERBB4 TFAP2A USP9X KRAS NR3C1 ZIC3 CCNE2 SETD1A UBR4 ACTL6A PDGFRA CREBBP ERBB2 KAT8 KLF5 STK11IP BCL6 TYK2 AKAP9 BOC NCAPG THADA IL3RA MTIF2 PTPRC PTPRF HECW2 VAMP7 HUWE1 SRCAP TXN MYO7A ARID1B GRIP1 SMARCA4 TUBB4A AGO1 HCGV PTK2B MED21 SNRPN HEL114 HRAS RANBP2 POLA1 Nbla10317 APOB EN1 AKAP12 SALL1 ATR TRIM7 LAMA1 BRCA2 BRAF FRAS1 PTEN SAFB2 RUNX2 SNX9 CTNNB1 TRRAP KMT2A LATS1 NELL1 PAN2 PPFIBP1 MLL2 TTK TTN ATM RB1CC1 EEF1A1 DMD KMT2B MTA2 MED1 MAST1 CD44 GBF1 NRG1 NUAK1 PRKDC NFE2L2 FGFR3 IGSF21 PTPRB MAP2K1 PMC6036173__F2 Screening Mammalian Cochlear Hair Cells to Identify Critical Processes in Aminoglycoside-Mediated Damage CDC42 HRAS COMP TLR4 EGFR GRB2 MTOR SRC KRAS CDK4 PMC5114520__F1 Double-strand break can be repaired by cNHEJ with minimal end processing RAD50 RAD51 LIG1 MRE11A BRCA1 BRCA2 PARP1 PMC3095949__F3 Functional pathway analysis of the 28-gene prognostic signature using Ingenuity Pathway Analysis DUSP5 HSP90AB1 DBF4 SLC25A5 FCAR RAD52 UBQLN2 TMEM97 HSPG2 MSH2 MMP12 SP1 PMS2 WRN RRM2 KLRK1 GBP1 S100P NR3C1 CSTF1 CHUK INPPL1 BIK TM4SF1 PMC7084279__F7 Detailed analysis of the 13 out of the 23 screened genes in “monoamine GPCRs” pathway HTR1F HTR7 HTR4 CHRM1 ADRA1A CHRM3 HTR2A DRD3 HTR2B ADRB3 HTR6 CHRM4 DRD1 HTR1B DRD2 DRD4 5HT1A HTR1E HRH1 CHRM5 HTR5A HTR1D CHRM2 DRD5 ADRB2 ADRB1 HRH2 PMC7397304__F6 Possible antioxidant signaling pathways regulating dexamethasone-induced muscle apoptosis by quercetin BAX BAD FOXO1 SMAD2 PMC6073502__F3 Interaction of proteins 3 days after hyperoxia ALB SUMO3 HEL-S-2a HEL-S-269 FBP1 HEL-S-32 ENO1 ADD2 HEL-S-100n PS1TP5BP1 HEL-S-34 PMC8548344__F2 Crosstalk between Hedgehog and other pathways in the intestinal tract NOD2 NUMB SMO WNT2B CTNNB1 PMC8548344__F1 Paracrine Hh signalling in the mammalian intestine HHIP SUFU GSK3B SMO GAS1 PMC6073502__F2 Proteins with influence on cell-death related signal transduction (green/light green: up-regulation, red/light red: down-regulation) MEP1A KRT2 RPSA HEL-S-269 ADD2 HEL-S-100n GDA HEL-S-34 ALB STOML2 HEL-S-2a PPP2R2A HEL-S-102 HEL-S-32 ENO1 PS1TP5BP1 PMC6073502__F1 Ingenuity pathways analysis (IPA) functional network generated for data of NH0-, NH3-, and NH7-groups HEL-S-101 MEP1A KRT2 SURF1 MAPKAPK2 CYCS IGFBP1 PLA2G3 SREBF2 CS IL6 FOS GDA SUMO3 MAP2K4 STOML2 INSR HEL32 HEL-S-102 RAB1 PBR HEL-S-32 MAPK10 IL1B PMC9310475__F1 Which patients are prone to suffer liver metastasis? A review of risk factors of metachronous liver metastasis of colorectal cancer EGFR APC GC BRAF GRB2 MTOR CTNNB1 PMC11607765__F1 Clinical role of Aldehyde dehydrogenase-1A1 (ALDH1A1) in pancreatic cancer HEL-S-53e GSK3B SRC PMC4899241__F6 Biological function of extracellular HMGB1 is redox dependent CXCL12 HMGB1 TIRAP PMC8981326__F5 Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation OGA MYB GATA1 RUNX1 ST3GAL6 FUT9 EVI1 FUT7 B4GALT4 PMC3187860__F1 Brain Arteriovenous Malformation Pathogenesis: A Response-to-Injury Paradigm EPHB4 ENG SMAD2 PMC5450331__F1 Signaling pathways of TLRs include MYD-88 independent and MYD-88 dependent pathways TLR9 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 RAC1 MYD88 TLR3 TLR4 TLR7 FADD PMC7251742__F9 Hypothetical scheme furtherly illustrates the mechanism of which polydatin improves osteogenic differentiation of hBMSCs via stimulating the expression of TAZ in the BMP2-Wnt/Beta-catenin pathway DKK1 APC BMP2 RUNX2 CTNNB1 PMC5954114__F2 GAS6/TAM signaling pathway GRB2 PMC5954114__F1 GAS6 and representative TAM family receptor EGF GLA PMC8397419__F8 Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Improve Ovarian Function and Proliferation of Premature Ovarian Insufficiency by Regulating the Hippo Signaling Pathway LATS1 LATS2 MSC PMC10138370__F6 GCN2/eIF2A/ATF4 Pathway in the Liver and Induction of FGF21 in Young Goats Fed a Protein- and/or Phosphorus-Reduced Diet TF TES PHGDH SHMT1 PSAT1 HEL-S-51e PSPH PMC4878851__F5 Lifecycle of cardiac Nav1.5 and potential phenotypic modifiers CAV3 NEDD4 FOXO1 TBX5 SCN5A PMC4615692__F1 Bile acid metabolism and signaling in cholestasis, inflammation and cancer CYP8B1 HSD3B7 CYP7B1 CYP27A1 PMC4125208__F4 Ingenuity pathway analysis (IPA) revealed TGF-beta signaling as the top “connected” network of differentially methylated candidates in HDM-exposed group PDE10A BMP3 P4HA2 SMAD2 CREBZF IL36B SKI UNC93B1 TRPM2 SLC25A12 PLCL2 MSR1 CARTPT PMC3368606__F2 Assembly of targeting patches and inside–out orientation of the secretory pathway CDC42 RHO PMC5752491__F3 Integrated analysis of chromosome copy number variation and gene expression in cervical carcinoma ATR CDC20 PCNA CDC6 ORC6 APC SMAD4 ORC1L MYT1 INS ORC3 SKP2 ORC2 CDK7 CDC45 CDK2 ATM PMC3801100__F1 RSK isoforms control motility and other aspects of tumor cell invasion and metastasis JUN VASP RHO PMC9200208__F3 Low-dose tissue plasminogen activator in patients with refractory hypoxia due to presumed microthrombi in pulmonary vasculature in coronavirus disease 2019: A case series and review of the literature PLG GLA PMC10266771__F1 Proposed mechanism for the regulation of NRAS mutation-driven hematopoietic malignancies involves the CBL/JAK2/RAB27B signaling axis CBL RAB27B ZDHHC9 NRAS PMC9681929__F3 Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression RNASEL BCL2 MTOR MYC PMC4278301__F1 Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans PTPN22 NAAA PC FAAH GDE1 PMC7312468__F1 The MNK1/2-eIF4E axis NF1 BRAF NRAS PTEN MTOR EIF4E PMC9181879__F1 Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways RHEB TSC2 TSC1 EGFR SMAD2 APC PTEN GRB2 SMURF2 CTNNB1 PMC9681929__F2 Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression CNOT1 USP15 STAT2 FNDC3B SPOCK1 PPP1R10 MEF2C PMC6800061__F2 TARGETING INFLAMMATION IN METABOLIC SYNDROME LPL LTB TG LTA LOX LDLR GPIHBP1 VCAM1 PMC6445151__F3 Differential network for the pathway “Signaling by NOTCH1” in the lateral compartment UBC DTX1 ITCH RBPJ MAML1 JAG2 CREBBP SNW1 EP300 MAML2 NOTCH1 KAT2B UBB PMC3967171__F2 Sex hormones and SREBP selectively regulate expression of Aldh1 ALDH1A3 HEL-S-53e ALDH1A2 PMC7608746__F1 SPRED proteins and their roles in signal transduction, development, and malignancy SPRED1 GRB2 PMC6912516__F2 Schematic representation of main ACVR1 signal transduction BMPR2 ACVR2B SMAD1 ACVR2A DKFZp781O1323 ACVR1 RHO PMC6445151__F4 The differential network for the pathway “InlA-mediated entry of Listeria monocytogenes into host cells” in neuroblastoma tumors between HR and non-HR patients UBC CTNND1 RPS27A SRC UBB PMC4010328__F5 TOB1 was involved in regulation of tumor growth and metastasis via the PI3K/PTEN signaling pathway EGF TOB1 PTEN CCND1 CTNNB1 PMC7752859__F15 The immunomodulatory activity of Ligilactobacillus salivarius TUCO-L2 isolated from llama (Lama glama) milk in porcine intestinal epithelial (PIE) cells CXCL9 JUN CXCL5 CD14 SIGIRR IRAK1 IRAK2 CXCL10 TRAF6 CXCL8 IRAK4 FOS MYD88 CXCL11 TLR4 CCL8 IL1B PMC4704494__F3 Chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells PTEN KRAS CTNNB1 PMC9589297__F4 Traditional Chinese medicine for hypertrophic scars—A review of the therapeutic methods and potential effects TRPM7 SMAD2 TGFBR1 PMC9589297__F5 Traditional Chinese medicine for hypertrophic scars—A review of the therapeutic methods and potential effects STAT3 TGFB1 CTNNB1 PMC6128439__F6 mTOR pathway RHEB RPTOR RPS6 EIF4B TSC1 INSR ULK1 RS1 PC MTOR ELF3 EIF4E PMC6674869__F8 Intracellular signaling pathways downstream of p75NTR and TrkA in sensory neurons NGF TRPA1 TRPV1 PMC316957__F9 How ECSIT may participate in Toll/IL-1 signaling ECSIT TRADD TRAF5 TRAF6 TNF TRAF2 MYD88 PMC4299612__F2 Regulation of Toll-like receptor (TLR) signaling during bacterial lung infections TBK1 TIRAP CXCL1 TAB3 CXCL2 IRF3 IRF7 TRAF3 MYD88 CD44 TLR1 TLR4 CYLD PMC2649968__F4 Participation of DNA repair in the response to 5-fluorouracil MSH6 ATR MSH2 PMS2 SMUG1 PMC5548615__F1 Emerging role of PI3K/AKT-mediated epigenetic regulation in cancer PCNA PML EZH2 PMC5641208__F1 S100A4 in cancer progression and metastasis: A systematic review S100A4 APC LRP5 MTOR CTNNB1 PMC3375057__F2 Neurotrophins, the ERK MAP kinase signaling cascade, and GSK-3 BAD MAP1B GRB2 BDNF CTNNB1 PMC8043969__F1 Germline Variants that Affect Tumor Progression PIK3CA CIC SF3B1 CTSW GNA11 PTEN RBFOX1 GRB2 MTOR PMC6800568__F1 Innate immune mechanisms in SLE DNASE1L3 CGAS TLR9 TLR7 CXCL10 TREX1 IRAK4 IL1B MYD88 PMC5581236__F7 SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling SUMO1 HEY2 SENP1 DLL4 HES1 NOTCH1 PMC3418056__F5 Postulated interactions between 20-HETE and RAS in the vascular endothelium EGFR PMC5412423__F6 Ceramide metabolism in desipramine-pretreated mice undergoing septic cardiomyopathy ASAH2 CERS5 SMS SPHK2 SGPP1 CERS2 SPHK1 DEGS1 PPP2CA SMPD1 SMPD2 PMC3197858__F1 Fatty acid synthase as a potential therapeutic target in cancer ACLY FASN HEL-S-5 ACACA PMC2592794__F1 Monosodium urate (MSU) crystals activate monocytes via the Toll-like receptor (TLR) pathway and the inflammasome TLR4 CD14 IL1B MYD88 PMC84916__F8 The mechanism of regulation of PLCG2 tyrosine phosphorylation and activation by LAT SYK FYN PLCG2 LAT LYN GRB2 PMC7895520__F7 Mechanism of the protective effect of spermine against high glucose-induced diabetic podocyte injury SQSTM1 MTOR ATG5 PMC11050262__F8 Gene expression changes in GO terms: (A) base excision repair, (B) mismatch repair, and (C) homologous recombination pathways in response to high–THC extract #18 compared to DMSO control in the HT–29 CRC cell line RAD51B COMP MSH2 MSH3 BRCA2 MEI1 PC ATM PALB2 BLM PMC6443116__F7 Localized decidualization in the cycling human endometrium PTGIS PRL IGFBP1 PTGES PMC3091668__F4 Putative TLR signal pathway TBK1 TIRAP MAVS SIGIRR IRAK1 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR1 BTK MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC3913210__F2 Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction RAN GPR161 ARL13B EVC2 TCTN2 EVC TCTN1 DYNC2H1 BBS7 SUFU PTCH1 IFT25 SMO GLI3 PMC3913210__F1 Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction EVC GPR161 KIF7 CDON BOC SUFU PTCH1 SMO PMC3091668__F5 Putative TCR signal pathway CDC42 ZAP70 CSA2 RAF1 LAT ATF2 CTLA4 FYN BCL10 CSK ITK GRB2 LCK PMC11987372__F2 Expression and mechanism of action of chemokine family members in PNI CXCL12 GAP43 CXCL5 CXCL1 CCR2 S100A8 PTEN SETDB1 MTOR CCL2 XBP1 MYD88 ZNF382 NLRP3 CX3CR1 TLR4 CCL7 CXCL13 LIF CXCL2 HDAC1 ATF3 TLR3 IL8RB CXCR4 S100A9 PMC3035594__F3 Integrated view of Wnt pathway JUN PPP2R1B NKD2 DVL2 ARHA CSNK1A1 MYC PMC7870078__F5 Identification of differentially expressed genes involved in amino acid and lipid accumulation of winter turnip rape (Brassica rapa L.) in response to cold stress AGXT AASS PMC9530455__F4 mRNA-miRNA networks identify metabolic pathways associated to the anti-tumorigenic effect of thyroid hormone on preneoplastic nodules and hepatocellular carcinoma PYY NR1A2 PMC7771966__F1 Identification of UDP-glucose:glycoprotein glucosyltransferase (UGGT) 1/2 substrates PLOD1 HGF ALG3 ENPP1 ERO1B ALG12 SLIT2 ALG6 IGF1 FUCA2 ALG10 ALG13 ALG1 PLOD2 PMC6906582__F1 Toll‐like receptors (TLRs) and their downstream signaling IRF3 IRF7 PMC11965705__F1 Important pathways and their functions in pancreatic ductal adenocarcinoma EGF EGFR PTEN GRB2 MTOR CTNNB1 PMC4032125__F7 Molecular Evolution of the Yap/Yorkie Proto-Oncogene and Elucidation of Its Core Transcriptional Program TF PMC2929006__F5 Genetic basis of kidney cancer: a metabolic disease TSC2 BAD TSC1 FNIP2 FLCN PTEN FNIP1 PMC6906582__F4 Viral RNA sensing proteins and their downstream signaling ELF2 RNASEL IRF3 IRF7 OAS3 PMC7291824__F4 Ingenuity Pathway Analysis of gene networks CXCR3 OGT PCDH10 CD79B CDC14B TXNIP IL21R SULF2 IFNG JADE3 DUSP15 BCR CAMK2N1 N4BP3 STAT5B TCAF2 DOK3 LAT2 PTPRH PFKFB4 HSPA12B NUDT12 RNF11 SYNE2 MKS1 NAGA MRAP HVCN1 AURKB HLA-B GSTT1 ULBP3 GGTA1 FUT6 CD27 RPS6KA1 IGFBP1 CDC42EP1 TREM2 PGC SLAMF7 BTK AGRN MFGE8 PHLPP2 TNFRSF17 ZHX2 GAREM1 TLR8 CD151 CTDSP2 TLR7 A4GALT VPS36 EMILIN1 MGRN1 EAF2 ASH1L JCHAIN CYB561 COPA YTHDF1 ID1 FCMR SOCS7 ZC3HAV1 TFCP2 JMJD1C DEDD RPS6KA3 MAP2K1 ABCC6 SEMA3B CARD9 PMC3842494__F8 The proposed role of high CORT levels on the proinflammatory response triggered by LPS and related to MAP kinase–NFKB pathway in rat brain IL16 TLR4 GC IL1B PMC9369058__F6 Spotlight on Exosomal Non-Coding RNAs in Breast Cancer: An In Silico Analysis to Identify Potential lncRNA/circRNA-miRNA-Target Axis LEP INCA1 MAK BRCA2 BOK PTEN MTOR PMC3624394__F4 Comparative analysis of NOTCH signaling pathway components in calcium-differentiated 8E6-iHFKs and GSI-treated C-HFKs by qRT-PCR DTX1 HEY2 NUMB PSEN1 PSENEN ADAM17 JAG2 LFNG MFNG NOTCH3 DLL3 MAML2 HES1 NOTCH1 HES5 DLL4 NOTCH2 RBPJ HDAC1 NCOR2 MAML1 PSEN2 EP300 ADAM10 SNW1 PMC9671940__F2 Growth stimulation expressed gene 2 (ST2): Clinical research and application in the cardiovascular related diseases IL33 TRAF6 IRAK4 PMC9107782__F6 Manipulating the Wnt/Beta-catenin signaling pathway to promote anti-tumor immune infiltration into the TME to sensitize ovarian cancer to ICB therapy AMN PORCN DKK1 APC LRP5 LRP6 CTNNB1 PMC8396260__F9 Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NFKB Signaling through PTEN Activation in Hepatocellular Carcinoma CDH2 PTEN PMC9107782__F1 Manipulating the Wnt/Beta-catenin signaling pathway to promote anti-tumor immune infiltration into the TME to sensitize ovarian cancer to ICB therapy PORCN DKK1 APC GSK3B LRP5 LRP6 LEF1 CTNNB1 PMC8934553__F7 LECT2 Ameliorates Blood–Retinal Barrier Impairment Secondary to Diabetes Via Activation of the Tie2/Akt/mTOR Signaling Pathway LECT2 MTOR PMC4743122__F1 Schematic illustration of the mechanisms impairing VEGF-A/VEGFR-2 angiogenic signal in SSc FLI1 NRP1 VEGFA PMC2515871__F2 Roles of cis- and trans-Changes in the Regulatory Evolution of Genes in the Gluconeogenic Pathway in Yeast FBP1 MDH2 PCK1 PMC9516650__F1 Liquid biopsy to detect resistance mutations against anti-epidermal growth factor receptor therapy in metastatic colorectal cancer PIK3CA RAF1 EGFR BRAF MTOR KRAS PMC7779046__F2 The ‘Hedgehog Signaling Pathway’ page includes a description of the pathway, links to sub-groups and other related gene groups LAT SMO RET PMC10922197__F9 Mechanism by which NBP inhibits osteoclastogenesis is demonstrated KEAP1 CTSK NFATC1 TRAF6 FOS HEL-75 ACP5 PMC6586838__F2 Association between miRNAs of interest and their predicted targets in the insulin signaling pathway (A) and Type II diabetes mellitus pathway (B) BAD FAS MAFA GSK3B MTOR PDK2 INS EIF4E RHEB CRK TSC2 CBL TSC1 INSR FOXO1 GRB2 PMC2810358__F2 Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas MSH6 NASP RFC2 MSH2 FEN1 SMC3 SYNE2 NEK9 SMC1A SMARCC2 SUPT16H MCM5 MCM2 CCND1 SMC4 PMC7892432__F2 Mechanism of pyroptosis affecting endothelial cells in ALI HMGB1 CGAS GSDMD NLRP3 TLR4 PMC7892432__F1 Mechanism of pyroptosis affecting alveolar macrophages in ALI HMGB1 CGAS GSDMD NLRP3 TLR4 MYD88 PMC8911031__F1 Coenzyme A Restriction as a Factor Underlying Pre-Eclampsia with Polycystic Ovary Syndrome as a Risk Factor LPL PTDSS2 CERS5 PLSCR4 SPTSSA PTDSS1 CERS2 FASN PNPLA2 SGPP2 LIPG PLA2G2A SPHK2 HEL-S-5 DGKE LPCAT1 PMC8494658__F3 Where are we now? Emerging opportunities and challenges in the management of secondary hyperparathyroidism in patients with non-dialysis chronic kidney disease VIT CYP27B1 CYP24A1 CYP27A1 PMC6434466__F7 Osteopontin (OPN) stimulated monocyte chemoattractant protein 1 (MCP-1) production and migration of monocytes CSA2 TLR4 CD14 TRAF6 LBP MYD88 PMC4390087__F5 Beyond Mitophagy: Cytosolic PINK1 as a Messenger of Mitochondrial Health PINK1 BNIP3 FUNDC1 OPTN PMC6372909__F1 Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer EGF HBEGF EREG TGFA BTC HRG AREG MTOR PMC4194117__F1 SIRT2 controls the pentose phosphate switch SIRT2 SIRT1 PMC5415203__F6 Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency TBK1 RAD50 CGAS MRE11A IRF3 CARD9 PMC3356999__F1 Fatty acid regulation of hepatic lipid metabolism ELOVL2 SCD FASN FADS2 ELOVL5 ELOVL6 FADS1 PMC6803550__F7 Model illustrating metabolic processes AFP PC MTOR IMPACT PMC5487993__F9 Paraquat hijacks the pentose phosphate pathway to induce oxidative stress and cell death HEL107 GLS OGDH HEL-S-68p HEL-S-162eP CS PMC7412275__F2 Entry mechanisms of Old World (OW) and New World (NW) arenaviruses NRP2 EEA1 CD63 PMC6007949__F6 CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia BAX CD300A MTOR PECAM1 PMC3100327__F1 De novo Biosynthesis of Biodiesel by Escherichia coli in Optimized Fed-Batch Cultivation HEL-S-5 PDC FADD PMC4521418__F3 Brca1 pathway is involved in microglia from hSOD1G93A mice ATR MSH2 PCNA BRCA2 TERT VEGFA RBBP8 XPC DDB2 IFNG STAT1 IGF1 BRCA1 NFYA ATM ATF1 CCNB1 CCND1 PMC2760836__F2 New concepts in herpes simplex virus vaccine development: notes from the battlefield PDC MYD88 PMC3871878__F2 Hypoxia inducible factor pathway inhibitors as anticancer therapeutics MTOR VHL PMC10931690__F9 Diagram depicting the mechanism of neuroprotective effect of siponimod/BAF312 TNFRSF4 CXCL5 CXCL10 CCL20 FGF23 PMC5741702__F2 Localization of the polycystic kidney disease (PKD) proteins, the pathways implicated in its pathogenesis, and putative therapeutic targets SEC63 PRKCSH PC GLA GANAB MTOR SIRT1 PMC6170780__F4 Prediction of antiviral targets [reactions] from single-reaction perturbations in a virus-optimized system for CHIKV, DENV and ZIKV OMP PMC7409333__F1 Sphingolipid metabolic pathway (plus five sphingosine-1-phosphate receptors) CERT1 UGCG ACER1 CERK SGMS1 SGPP1 SPHK1 DEGS1 KDSR ACER3 PMC5702304__F3 Overview of human TLRs activated by exogenous and endogenous ligands, such as fragmented DNA from necrotic cells; adapted by permission from Macmillan Publishers Ltd, Nature Reviews Gastroenterology and Hepatology, 2006, vol TLR3 TIRAP TLR4 TAB3 IRF3 IRF7 TRAF3 IRAK4 MYD88 PMC4730344__F4 Induction of DNA repair by EGFR signaling RAD51 BRCA1 PRKDC EGFR BRCA2 ATM PMC4730344__F2 Cell death pathways after irradiation RB1 BAX CDK6 CDK2 BCL2 APAF1 ID1 CDK4 FADD PMC9370344__F7 Waterlogging Stress Induces Antioxidant Defense Responses, Aerenchyma Formation and Alters Metabolisms of Banana Plants ACLY SDHB FH HK2 PDC ENO1 ACCS PMC5071566__F8 Modulation of host AKT pathway by L FOXQ1 GSK3B CTNNB1 PMC3260274__F5 Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer PTEN PMC4778253__F4 Mesenchymal and endodermal signaling events EPHB3 NOG SOX2 SHH FGF10 WNT2B PMC6949159__F5 KEGG pathway: CELL CYCLE (A) and P53 SIGNALING PATHWAY (B) TSC2 ATR SIAH1 AIFM2 PERP ATM PTEN MDM2 MYT1 MYC SKP2 PMC8896082__F1 Effects of the probiotic cocktail on modulation of the NF-kB and JAK/STAT signaling pathways involved in the inflammatory response in bowel disease model TIRAP JAK3 NOD2 IRAK4 MYD88 PMC8514763__F3 Non-Coding RNAs Inducing Drug Resistance in Ovarian Cancer: A New Perspective for Understanding Drug Resistance LATS1 STAT3 LATS2 CIC ETV4 PTEN NLK MLSN2 BAK1 TNF SFRP1 CTNNB1 PMC4501477__F4 What’s the Damage? The Impact of Pathogens on Pathways that Maintain Host Genome Integrity TOPBP1 ATR RNF168 RNF8 ATM MDC1 PMC12025106__F3 The activated PI3K/Akt/mTOR/c-MYC pathway in metabolic reprogramming to dietary methionine sources RHEB TSC2 TSC1 PTEN PMC4501477__F3 What’s the Damage? The Impact of Pathogens on Pathways that Maintain Host Genome Integrity TOPBP1 ATR ATRIP RNF168 RNF8 ATM MDC1 PMC7312541__F1 Canonical Wnt/Beta-catenin pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC12025106__F1 Helicobacter pylori infection in methionine metabolism PMC8539574__F2 Glycation and Glycosylation in Cardiovascular Remodeling: Focus on Advanced Glycation End Products and O-Linked Glycosylations as Glucose-Related Pathogenetic Factors and Disease Markers OGA OGT GNPNAT1 PMC7407016__F1 Regulatory circuits driven by liganded ER-alpha for DNA stabilization (A), cell proliferation (B), and fuel supply (C) BRCA1 EGFR IGF1R MTOR IRS1 PMC6857900__F3 The Links between FTO and Colon Cancer STAT3 NPY CCND1 PMC8192426__F1 Contraction in airway smooth muscle (ASM) STIM1 ARHA RHO PMC9396278__F7 Novel regulated network mediated by downregulation HIF1A-AS2 lncRNA impairs placental angiogenesis by promoting ANGPTL4 expression in preeclampsia ANGPTL4 PMC6857900__F2 Simplified Version of the Canonical Wnt/ Beta-Catenin Pathway APC GSK3B CTNNB1 PMC4874655__F3 COLORECTAL CANCER ERBB3 TGFBR2 FZD10 APC LRP5 BRAF SMAD4 NRAS ERBB2 PTEN KRAS CTNNB1 PMC2815016__F4 Activation of the NFKB signaling pathway by farnesol is related to ER stress EIF2A TRAF2 CXCL3 PMC8313979__F3 Systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis CHD2 ST8SIA4 TF TH CHST3 MAN1A2 FUT4 ST6GAL1 FUT7 ST8SIA1 ATF2 ADNP MEF2C MGAT5 MGAT1 CREB3L4 MHC2TA DSEL CHST11 JDP2 PRDM1 ST8SIA2 IRF4 RUNX3 TCF7L2 FLI1 B3GNT5 CSGALNACT1 UST PMC2815016__F3 Farnesol induces ER stress and activation of the unfolded protein response PDIA4 ATF4 EIF2A XBP1 TRAF2 PMC8313979__F2 Systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis TF ST6GAL1 PMC6966677__F6 Cell proliferation and metastasis of gastric cancer by modulation of VGLL1 expression and activity VGLL1 TCF4 MMP9 LEF1 TEAD4 CTNNB1 PMC7957263__F1 Signalling pathways DKK4 involved in different kinds of cancer DKK4 APC ARHA CTNNB1 PMC8688647__F6 Network map of Elabela signaling pathway in physiological and pathological conditions BAX PIK3CA HEL113 CYCS MMP9 TNF COL3A1 CCL2 MAPK3 SIRT3 COL1A1 FOXO3A CASP3 MMP2 BCL2 PMC8688647__F5 Network map of Elabela signaling pathway in physiological and pathological conditions ARRB2 PMC8688647__F2 Network map of Elabela signaling pathway in physiological and pathological conditions PIK3CA NPHS2 TIMP1 SYNPO TGFB1 MTOR CCL2 MAPK3 SIRT3 IFNG FOXM1 POSTN REN COL1A1 MYH7 IL18 IL2 ATF1 CTGF ACE2 CREB1 LTBP2 MAPK1 BAX IL17A IL6 TNF HAVCR1 NPPA CASP3 BCL2 LCN2 NPPB PMC8688647__F1 Network map of Elabela signaling pathway in physiological and pathological conditions PIK3CA TGFB1 NCF2 TBXT MTOR NCF1 GDF3 ACTA2 COL1A1 NLRP3 FST RPS6KB1 IL18 AKT1S1 CCND1 CYBB PMC8688647__F4 Network map of Elabela signaling pathway in physiological and pathological conditions BAX CRH BCL2 IL6 MTOR TNF FOS IL1B AVP PMC6744284__F7 Differentially expressed transcripts in FSGS were enriched in the JAK-STAT pathway in the glomeruli IFNG GAS CD14 MTOR FOS PMC8688647__F3 Network map of Elabela signaling pathway in physiological and pathological conditions MAPK1 ATR TGFB1 EIF4EBP1 H2AX MTOR IL6 TNF CCL2 HAVCR1 PARP1 MAPK3 ATG12 RPS6KB1 MAP1LC3B2 CASP3 CHEK1 ATG5 PMC6744284__F6 Differentially expressed transcripts in FSGS were enriched in the JAK-STAT pathway in the tubulointerstitium IFNG JUN BAD SERPING1 FITM2 TLR3 GAS MTOR TNFSF10 KCTD12 FOS PMC6149884__F1 VAV1 signaling in lymphocytes PHC1 VAV1 RHO NOTCH1 PMC8079762__F1 Targeting Solid Tumors With BTK Inhibitors BAD BTK MDM2 PMC4281466__F1 TGF-beta signaling pathways SMAD4 RHO STRAP PMC6397804__F2 Poly(I:C)-toll-like receptor 3 signaling pathway and polarization of mesenchymal stem cells TLR3 TLR4 MSC IRF3 PMC11510049__F9 Comparative analysis of transcript and protein abundance in the HSP60-HSP70-TLR2/4 signaling pathway in children with severe malarial anemia CD40 CD83 CD80 MAP3K7IP1 CD69 TLR4 TAB3 MAL CD14 TRAF6 IRAK4 MYD88 PMC9178347__F2 Critical metabolic pathways and SAD/FADs, WRI1s, and DGATs cooperate for high-oleic acid oil production in developing oil tea (Camellia oleifera) seeds XK HEL-S-162eP STS PMC3926427__F1 FGF/FGFR signaling pathway EGF GRB2 MTOR PMC3376383__F2 Growth Control by Committee – Intercellular Junctions, Cell Polarity, and the Cytoskeleton Regulate Hippo Signaling PATJ CRB3 AMOT PALS1 PMC7880612__F1 Molecular tracing of prostate cancer lethality MYB PTOV1 LGALS8 SMAD4 EZH2 PTEN SPP1 CD44 WT1 TFF1 SOX9 ASCL1 CCND1 SOX4 PMC6443331__F5 AMPK-dependent anticancer activities of honokiol in ovarian cancer cells TSC2 TSC1 MMP9 MTOR PMC9437103__F3 Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics CITED4 ULK1 MTOR GATA4 ULK2 PMC4106164__F1 PD-L1 expression and tumor-infiltrating lymphocytes IFNGR2 CCL22 IFNGR1 CCR4 PTEN FOXP3 PMC5609723__F2 Aryl hydrocarbon receptor-mediated hepatotoxicity is a cumulative response to the overall burden of multiple disrupted pathways rather than a single adverse effect FGF21 AHR HEL-S-30 PMC9437103__F2 Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics IGF1 PTEN IGF1R PMC8236548__F1 Other side of the coin: dissecting molecular mechanisms behind hereditary breast cancer in search of therapeutic opportunities ATR RAD50 MRE11A BRCA2 CDK2 ATM PALB2 PMC9315891__F3 Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues RPE XK XDH PMC9315891__F2 Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues LPA FAS HEL-S-5 XDH PMC7710690__F2 PD-1 and PD-L1 interactions and mechanism of T cell inhibition ZAP70 CD80 PLCG1 BATF APC IL2 PTEN MTOR LCK PMC3338748__F1 High-Throughput Sequencing of mGluR Signaling Pathway Genes Reveals Enrichment of Rare Variants in Autism UBE3A RAF1 HOMER1 SHANK2 PTEN MTOR ARC PDK2 EIF4E RHEB HRAS SHANK3 TSC2 SYNGAP1 TSC1 NF1 PMC8229352__F1 Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment WIPI1 GABARAP ATG3 ATG12 ULK1 MTOR ATG5 PMC8229352__F5 Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment CD44 STAT3 FOXO3A EGFR WNT1 IL6 MTOR SRC YAP1 NOTCH1 CTNNB1 PMC8001024__F1 Cohesin cycle in human cells CDC2 ESCO1 WAPAL PLK1 ESCO2 SCT PMC5855797__F6 Signal transduction in relation to the IR GHSR PTEN PDK2 IRS1 PMC2948497__F6 cDNA Microarray Gene Expression Profiling of Hedgehog Signaling Pathway Inhibition in Human Colon Cancer Cells CDC2 POLE2 CDC20 E2F2 CDC6 DDIT4 CDKN2B TYMS CCNA2 CCNE2 TK1 CDKN1A AURKB DDIT3 CDK2 CCNB1 POLE TOP2A PMC5855797__F2 GPCR agonism bias towards insulin receptor activation EBP NMBR MMP9 IRS1 PMC8561165__F1 Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease VIT CXCL9 KYNU KMO PMC8561165__F3 Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease CXCL9 KMO IL18 PMC9486121__F3 Key signal transduction pathways and crosstalk in cancer: Biological and therapeutic opportunities GSK3B LRP5 LRP6 CTNNB1 PMC9486121__F2 Key signal transduction pathways and crosstalk in cancer: Biological and therapeutic opportunities PTEN MTOR PMC8126045__F1 Lytic Viral Replication and Co-Infections in the Oncogenesis and Immune Control of the Epstein–Barr Virus CD48 PLCG1 MAGT1 CD27 TNLG8A ITK PMC7199655__F1 Coupled-clock pacemaker system of the sinoatrial node HEL-S-11 PMC10571979__F8 Norrin signals through DVL1 to stimulate barrier properties DVL1 FZD4 TSPAN12 CLDN3 LRP5 LRP6 CLDN5 PMC9659209__F1 Histone Deacetylase Functions in Gastric Cancer: Therapeutic Target? TF CD44 HDAC1 CITED2 MORC2 HDAC2 PMC8243427__F2 MicroRNAs: emerging driver of cancer perineural invasion RAN DGCR8 AGO2 DROSHA PMC8576699__F6 Synergistic effect of chidamide and venetoclax on apoptosis in acute myeloid leukemia cells and its mechanism HDAC1 STAT3 BAX CDK2 SOCS3 PMC4046179__F5 98 proteins that showed significant changes in oxidation levels with HFHS diet were subjected to IPA SDHA SDHB SI CYC1 UQCRH SDHC COX6B1 PMC6008255__F1 Different Wnt signaling pathways APC GSK3B LRP5 PTK7 LRP6 RHO TEF RAC1 DAAM1 CTNNB1 PMC3271860__F7 THE ROLE OF IGF-1 SIGNALING PATHWAY IN CISPLATIN-RESISTANT LUNG CANCER CELLS IGF1 IGF1R PMC3877826__F9 Model of Interaction with the b-Dependent Developmental Control Pathway.(A) Filamentous growth is triggered by bE/bW-dependent induction of rbf1 expression CLP1 PRF1 PMC2654411__F6 Time-course Comparison of Xenobiotic Activators of CAR and PPARA in Mouse Liver CD27 EGFR HEL-S-25 POSTN IL18 SMC2 AGA PRKAR1A SMC4 IL1B DBF4 GNG4 SP1 RRM1 NGFR ORC2 NFYB TFPI2 CNTFR MCM7 SCARB1 SHOC2 IRF2 MCM6 UHRF1 SYN1 PMC7432002__F3 Interaction among MyD88, Toll-like receptor 4, IL-1 receptor signalling pathway in the innate immune response to tick-borne pathogens that could positively control the IFNG secretion; meanwhile, there is lack of IL-18 and IL-12 due to MAS SOCS1 IFNG IL12A STAT5B TLR4 IL18 IRAK2 IL1A IRAK4 MYD88 PMC10982647__F8 Metabolic rewiring mechanisms in drug-resistant breast cancer cells PRMT1 PHGDH FASN PMC8328898__F2 Membrane-Associated Mucins of the Human Ocular Surface in Health and Disease IRAK1 TRAF6 MYD88 PMC7432002__F5 Interaction between IL-1B and I-kB kinase/NF-kB signalling pathway, which have positive activation of Nuclear Factor Kappa B Subunit 1 FAS CASP8 JAK3 IL17A TNFRSF10A NFKB1 IKBKB IL18 JAK1 TNFSF10 IL1B FADD IL12RB1 PMC8824439__F1 CCM in Mtb MCC MAL CIT PMC2654411__F3 Time-course Comparison of Xenobiotic Activators of CAR and PPARA in Liver RXRA CYP2C8 CYP3A4 PMC3271860__F3 IGF-1 SIGNALING PATHWAY IN CISPLATIN-RESISTANT LUNG CANCER CELLS PPIC KRT1 RAB30 CPVL NTS SKIL CTSG LXN ALB RB1 SOX6 CD24 FYN DHX34 APLN ITK ZEB2 HTT UBB MLPH ARHH VAV3 SLPI ID2 MYH1 CTSL PLG RPH3A HEL-S-28 LRP6 TPRN HRAS HGS FRY HEL23 IGF1 LIN7A PTX3 MEP1A ARHG E2F7 FST IL18 CASK PKP2 CFH PRNP PDK4 PEG10 DIPLA1 STX2 PKIA RRAS LYN PS1TP5BP1 PMC7432002__F4 Interaction between MyD88 and JAK-STAT pathway, linked to IFNA; this interaction is mediated by suppressors of cytokine signalling 3, SOCS family proteins which are part of a classical negative feedback system regulating cytokine signal transduction IFNA7 IFNA6 IFNA17 IFNA8 IFNA16 IFNA21 IFNA10 JAK3 IRAK2 IFNA2 SOCS3 IRAK4 MYD88 IFNA1 PMC8888851__F1 Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity IFNG TH GDF15 ACE2 PMC7277837__F13 Hypothesized pathway for the production of prokaryotic glycolipids in C LPA GAL FAS PC PMC7664215__F2 Bioactivities and possible mechanisms of pterostilbene STAT3 MMP2 MMP9 MTOR SRC RAC1 IL1B PMC8450498__F1 Structural Analysis of SARS-CoV-2 ORF8 Protein: Pathogenic and Therapeutic Implications NPTX1 PLAT LOX INHBE FBXL12 POGLUT2 TM2D3 SDF2 PLOD2 PUSL1 GGH PLD3 PLEKHF2 UGCGL2 FKBP7 NEU1 PMPCB HS6ST2 CHPF NPC2 SIL1 IL17RA COL6A1 EDEM3 ITGB1 CHPF2 ADAM9 HYOU1 PMC8752802__F6 IFNG signaling integrity in colorectal cancer immunity and immunotherapy CXCL9 STAT1 IFNGR1 EZH2 JAK1 CXCL10 PMC8752802__F3 IFNG signaling integrity in colorectal cancer immunity and immunotherapy IFNG IFNGR1 AP3D1 PMC9234286__F2 Insight Into Rho Kinase Isoforms in Obesity and Energy Homeostasis ROCK1 ARHA PMC9234286__F1 Insight Into Rho Kinase Isoforms in Obesity and Energy Homeostasis FGF21 ARHA PMC8752802__F1 IFNG signaling integrity in colorectal cancer immunity and immunotherapy CXCL9 IFNG IFNGR2 IFNGR1 JAK1 CXCL10 PMC7158223__F1 Post-transcriptional mechanisms influence proteome content LARP1 MTOR PMC7709131__F3 Complement functions in the context of cancer PTX3 FAS FH WWOX CR2 PMC7709131__F1 Complement system schematic summary MASP1 CD59 FH C2 VTN CD46 CD55 C4B_2 PMC12071759__F1 TAM metabolization pathway CYP1A2 UGT1A4 CYP2E1 CYP2C19 UGT1A10 CYP2C9 CYP1B1 UGT1A8 CYP1A1 CYP3A4 PMC7158223__F2 Post-transcriptional regulation of stem cell identity under conditions of stress HSF1 ELF2 ATF4 XBP1 PMC9491571__F2 Over- and under-expressed genes are highlighted in WNT signaling pathway BAMBI INVS ROCK2 C2 STOM APC NOTUM CER1 SMAD4 SKP1 NLK PMC2533280__F1 Wnt, Activin, and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood MESP1 HOXB1 CER1 FOXA2 PMC6741067__F14 The signaling cascade activated by the CaSR that induces the arrival of ZO-2 to TJs CASR WNK4 PC PMC3174204__F6 Conserved Regulation of p53 Network Dosage by MicroRNA–125b Occurs through Evolving miRNA–Target Gene Pairs ATR BAD PRKRA HEL111 TP63 ATM PTEN PMC2242750__F1 Schematic representation of GADS-related signaling in T cells PLCG1 LAT ITK GAB2 PMC4185231__F6 TLR2-dependent activation of Beta-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation GSK3B ALDH1A2 FOXP3 PMC9024760__F1 Cell Culture Media, Unlike the Presence of Insulin, Affect Alpha-Synuclein Aggregation in Dopaminergic Neurons PTEN GRB2 MTOR PMC11279058__F2 Mycoplasma hyopneumoniae generates immune evasion by modulating the host immune system BAX TLR4 TNF XBP1 IL1B PMC3423339__F7 BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: Implications for Hereditary Hemorrhagic Telangiectasia Type II ID1 RBPJ ID3 PMC3935825__F1 Accurate measurement of nicotinamide adenine dinucleotide (NAD+) with high-performance liquid chromatography NRK NAMPT PMC4580256__F1 PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma PTEN MTOR PMC9317725__F1 Microbial Poly-Gamma-Glutamic Acid (Gamma-PGA) as an Effective Tooth Enamel Protectant C6 HEL-S-62p PMC7070543__F9 Schematic presentation of erinacine A prevention against MPP+-induced neurotoxicity via either induction of the p-PAK1/cdc42/PI3K/AKT/LIMK2 cell survival pathways or the reduction of the IRE1A/TRAF2/ASK1/GADD45/p21 cell death pathway CDC42 LIMK2 PAK1 TRAF2 PMC8529123__F3 MCM3AP-AS1: An Indispensable Cancer-Related LncRNA SLC39A10 FOXK1 SPARC PTEN EIF4E PMC6064744__F2 Schematic representation of cellular mechanisms possibly implicated in miRNA dysregulation in prion diseases TF ADAR APOBEC1 DROSHA PMC8529123__F2 MCM3AP-AS1: An Indispensable Cancer-Related LncRNA FOXA1 CENPF ARPP19 SENP1 FOXF2 CDK4 PMC5529928__F1 CXCL12/CXCR4 signaling and related pathways in HCC progression CXCL12 SMAD2 CXCR4 PMC6099188__F1 Bile acids are synthesized in the liver from cholesterol by two metabolic pathways known as the neutral (or classical) and the acidic (alternative) pathways CYP8B1 BAAT CYP7A1 GCA CYP7B1 CYP27A1 PMC7052306__F1 Activity-dependent synaptic plasticity at the Drosophila larval NMJ PMC4790094__F2 Divalent cation signaling in immune cells STAT3 TRPM7 MAGT1 BCR LCK PMC4879098__F1 Lysosomal–autophagy pathway BAX CAD M6PR PMC5336271__F4 Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology SOCS1 FLT3 BRD4 STAT3 STK11 OSM SPHK1 IGFBP4 PTEN MYOCD MYC MAP3K14 CTNNB1 MAP3K8 ORMDL3 TSPYL5 ANGPT1 SNAI1 SMO MAPK1 FBN1 IRF7 VEGFA TNF PRRX1 CNTF NRG1 EIF3E HOXA13 BMP2 ERBB2 PMC5520491__F1 Classical and new Wnt/Beta-catenin pathway canonical and non-canonical pathways JUN APC RYK RHO SKI PMC7792426__F7 Defining the Cardiac Fibroblast Secretome in a Fibrotic Microenvironment IGF1 IGFBP5 SMAD2 CCL20 IGFBP6 PMC4999106__F2 Main components of innate immune system in epidermis and their role in atopic dermatitis (AD) NLRP1 PDC NOD1 PMC4907392__F5 Network computed by Xtalk for crosstalk from the Hippo signaling pathway (A) to the TGFB signaling pathway (B) WWTR1 SMAD2 SMAD4 YAP1 PMC7876357__F5 Hyaluronan, Transforming Growth Factor B, and Extra Domain A-Fibronectin: A Fibrotic Triad BAMBI TLR4 USF2 EGFR SMAD2 SMAD4 ATM RHO SRC MYD88 PMC4907392__F4 Paths used to facilitate literature validation MAPK1 PRLR JUN SP1 GSK3B HIF1A FOS MAPK3 PMC7957049__F2 Wnt signaling pathway activation and inhibition APC GSK3B CTNNB1 PMC3701138__F1 Main branches ofWnt signalling pathways in neuronal development CDH2 ROR2 LRP5 LRP6 RYK RHO CTNNB1 PMC4907392__F6 Crosstalk network constructed by Xtalk from the NFKB Pathway (A) to the Neurotrophin Pathway (B) using the KEGG-family network JUN MAPK8 FOS PMC6166714__F7 IRAK4 and MyD88-dependent TLR signaling TAB3 IRAK1 TRAF6 IRAK4 MYD88 PMC3425527__F1 Hedgehog signalling SUFU PTCH1 SMO PMC7851346__F8 URA-mediated EAE Mitigation by Directly Targeting Aryl Hydrocarbon Receptor CSF2 AHR PMC5015539__F2 Restoring immune tolerance in neuromyelitis optica CD44 CD24 CD19 PREB PMC8038143__F5 Link between chemoresistance and MMP-7 shedding of Fas ligand BAX ATR FAS ATM FADD PMC8369429__F2 Peptides that immunoactivate the tumor microenvironment HEL-S-66p CD80 TIGIT BTLA LAG3 PMC7763502__F1 Effect of Brassicaceae bioactives compounds upon the transcription of genes related with inflammation KEAP1 TLR4 SFN PMC5393410__F3 Cancer Transcriptome Dataset Analysis: Comparing Methods of Pathway and Gene Regulatory Network-Based Cluster Identification STAT3 PIK3CA SHC1 SLC2A4 PIK3CD JAK3 PTPRF PLA2G3 SOCS2 IL21R PTPRC FGF8 PLA2G10 STAT1 VEGFB FYN STAT5B PDPK1 OSMR ITK FLT1 KDR MMP7 CSF2 FGF22 IL7R FGF10 FOS CNTFR PREX1 PRKCI TCF7L2 FZD4 IL9R IFNAR1 PLA2G6 MAPK7 IL23R IL10RB FGF12 HGF FGF14 LAT EGFR IL2RG IL2RA NR1C2 PLA2G2D IL11RA INS CSF3R RPS6KA6 SHC4 CCND2 INSR FGF9 ATF4 CDK4 CCND3 JUN PIM1 LEPR PDGFA PLA2G4F PLA2G12A PLA2G2C FGF2 SOCS7 FGF7 IL2RB PDGFRA IL6ST STAT4 JAK1 STAM2 TYK2 GAB2 LEF1 FGF18 PMC9228816__F2 Beyond Moco Biosynthesis―Moonlighting Roles of MoaE and MOCS2 TF MOCS3 MBIP MOCS2 APP XDH SUOX PMC8099739__F2 VB10, a new blood biomarker for differential diagnosis and recovery monitoring of acute viral and bacterial infections IFNG IFIH1 CCN3 ISG15 RUNX2 CTNNB1 PMC10552298__F1 , Hypothetical VOC production pathway originated from lipid peroxidation of membrane lipids LOX HEL-S-133P PMC3507272__F1 Schematic diagram showing the RAS-MAPK signal transduction pathway RAF1 BRAF GRB2 PMC8256158__F7 Early p38 Activation Regulated by MKP-1 Is Determinant for High Levels of IL-10 Expression Through TLR2 Activation STAT3 SP1 TLR4 JAK1 TNF PMC3430113__F4 Schematic depicting a central role for transforming growth factor (TGF)B1 signaling in osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis (LCH) LPA STAT3 TGFB1 FASN PC FOXP3 PMC6004768__F1 Defective identified pathways in immunodeficiencies predisposing to high susceptility to Epstein–Barr virus (EBV)-driven B-cell lymphoproliferative diseases CD48 CTPS1 MAGT1 CD27 TNLG8A ITK MICA CORO1A PMC1410746__F3 Genmapp view of the epidermal growth factor (EGF) signaling pathway HRAS EGF SOST MBP EGFR NRAS ERBB2 MAP2 GRB2 PMC4454399__F2 Top Ingenuity Pathway Analysis (IPA) interactome derived from transcriptional regulators found in the Vesiclepedia database FUS ALYREF COPS5 YBX1 PURB CAND1 MNDA IRF6 RCOR2 BTG1 RUVBL1 NPM1 RUVBL2 NACA PMC7876795__F3 Alternative signaling activation induced FGFR-TKI resistance ERBB3 EPHB3 FRS2 EGFR PTEN MTOR PMC6480527__F10 Model of the Nrf2-mediated oxidative stress response pathway in bovine granulosa cells under moderate oxidative stress conditions and under antioxidant (quercetin) supplementation KEAP1 NQO1 MAF PMC4937204__F1 cGMP-PKG signalling in the cardiomyocyte RGS2 PGC SMAD2 RGS4 TRPC6 GATA4 PMC5893408__F1 Sphingosine-1-phosphate receptors and innate immunity S1PR1 S1PR3 S1PR2 PTEN RHO S1PR5 S1PR4 PMC9204905__F6 Hypermethylation of TMEM240 predicts poor hormone therapy response and disease progression in breast cancer UGT1A1 CYP1A2 UGT1A4 UGT1A3 ST1A5 HSD17B3 CYP2E1 UGT1A10 CYP1A1 SULT1E1 STS CYP3A7 UGT2A1 CYP2B6 SULT1A1 CYP2C19 HSD17B1 SULT2A1 CYP2C9 CYP2C8 UGT2B11 CYP3A4 HSD17B7 SULT1B1 PMC11010261__F1 YAP/TAZ‐TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma LATS1 MOB1A MOBKL1A LATS2 DLG5 TEAD2 TEAD3 HEL-S-28 RHO NF2 SRC TEAD4 PMC6117460__F1 A Retinoic Acid Signaling Pathway to Promote ProliferationRetinoic acid, acting via HIF1A and VEGF, is necessary for S-phase re-entry of NSPCs CDK6 HIF1A VEGFA CDK4 PMC11544849__F4 Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research EGF CTNNB1 PMC8485144__F3 Molecular Profiling of Spermatozoa Reveals Correlations between Morphology and Gene Expression: A Novel Biomarker Panel for Male Infertility LTBP2 CCDC60 AURKA CHFR FRS2 SMOC2 FOXP4 PARK2 TRIM2 RGMA TERT AHRR SYNE1 SOX6 CACNA1H COL4A2 DNAH2 GATA4 TEF RALGPS2 ZNF239 PRKG1 PMC3999155__F6 HSCARG Negatively Regulates the Cellular Antiviral RIG-I Like Receptor Signaling Pathway by Inhibiting TRAF3 Ubiquitination via Recruiting OTUB1 TBK1 MAVS IRF3 TRAF3 PMC2670022__F1 Pharmacological targeting of the serotonergic system for the treatment of obesity POMC MC4R NPY ARC AgRP PMC2966096__F7 A hypothetical model of PAR-1 and PAR-2 activation by coagulation proteases when either EPCR or an unknown FX/FXa receptor is occupied by natural ligands TH APC PC ARHA RAC1 PMC7031348__F2 Inflammation and muscle protein turnover STAT3 IGF1 GSK3B IRS1 PMC10381408__F4 Compound K Production: Achievements and Perspectives IPP PGM2 PMC10381408__F3 Compound K Production: Achievements and Perspectives ARAF RB1 CMC1 F2 PMC8856628__F1 Mechanism of action of GEM in PDAC treatment CDA RRM1 DCTD PMC2891859__F1 General overview of BDNF and GDNF signaling mechanisms FYN GDNF BCL2 RHO BDNF RET PMC7016420__F3 Metabolic reprogramming of HSC TES GOT2 GPT2 MAL PMC6511648__F1 LSD1–NOTCH–ASCL1 Axis in Small Cell Lung Cancer (SCLC) REST ASCL1 HES1 NOTCH1 PMC5818364__F2 Acyl-DHAP pathway of ether lipid synthesis LPA AGPS GNPAT FAS FAR1 HEL-S-5 PMC3632562__F4 PAK1 Protein Expression in the Auditory Cortex of Schizophrenia Subjects CDC42 PAK1 LIMK1 RAC1 PMC1782125__F2 Signal transduction of TNFRI LTA LTBR TRADD RELA TNF TRAF2 FADD PMC4779661__F3 Relationship between cellular fatty acid (FA) metabolic pathways and observed associations of FAs and enzyme acitivity estimates (EAEs) with colorectal adenomas FAS SCD ELOVL6 PMC3230512__F1 Model showing the various molecular components associated with the store-operated calcium entry pathway ORAI1 STIM1 TRPC1 PMC6136097__F1 Current putative prognostic biomarkers in glioblastoma PTEN HEL-S-26 MGMT PMC8074247__F10 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer NGF ATR LOXL2 HGF IGF1 MAK ATM TERT HEL-S-87p FECH CXCR4 PMC8892134__F1 Targeting the IGF/PI3K/mTOR pathway and AXL/YAP1/TAZ pathways in primary bone cancer STAT3 AXL ABL2 PTEN IGF1R RHO IGF2 LATS1 RHEB TSC2 LATS2 TSC1 IGF1 INSR GRB2 PMC11641605__F6 Crosstalk of ECM and hypoxia in the Hippo signaling pathway LATS1 FRMD6 LATS2 EGR1 PATJ ERBB4 AMOT AJUBA RHO TBX5 PMC11641605__F5 Hypoxia regulates intracellular signaling through multiple mechanisms LATS1 EPO RHO PMC3529674__F5 MyD88-independent TLR signaling TBK1 TLR4 IRF3 PMC11641605__F3 Intracellular signaling regulation of the ECM signal transmission LATS1 LATS2 VAV2 PMC5484492__F5 Meta-analysis of miRNA expression profiles for prostate cancer recurrence following radical prostatectomy FOXA1 STAT3 SYK MS4A2 LIMS1 PARVA FCER1A PBX1 PTPN1 MYC LAMB1 HRAS RICTOR INSR FLT4 FOXO1 RS1 Nbla10317 RET PMC5484492__F4 microRNAs in cancer CD44 FAS APC ATM PTEN MYC NPL SOX4 PMC9583386__F1 Farnesoid-X receptor as a therapeutic target for inflammatory bowel disease and colorectal cancer CD80 NGF NLRP3 ARG1 CD163 PMC8882121__F6 Olfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration through POU5F1/OCT4 and ESR1 signalling cascades RPTOR TGFB1 ARHG RAF1 EPHA2 PLD2 ARPC2 ANXA2 PTEN HEL70 ARHA TUBB6 VCP MAPK14 PROX1 TXN EFNB1 RALA ACTN4 CDK2 IGFBP7 HEL-S-87p CLTC PMC4331664__F5 The metabolic pathways of Mtb that interconnect glycogen, Tre and other carbohydrates MAK MAL PMC2802426__F1 Molecular mechanisms that regulate ionotropic glutamate receptor distribution during hippocampal mGluR-LTD induction and expression MAP1B PSD ARC PMC7040165__F2 Controlling pluripotency using small molecule inhibitors and growth factors SOX17 KLF4 BMP4 LIF SOX2 LEFTY2 FGF2 PMC7040165__F1 Extrinsic signaling pathways governing stemness of pluripotent stem cells LIF NODAL PMC2802426__F2 Schematic model of molecular mechanisms underlying regulation of gene transcription and protein translation during mGluR-LTD in postsynaptic neurons of hippocampal CA3-CA1 synapses EEF2K EGF MAP1B PSD EEF2 ARC GRB2 MTOR SRC CCND1 CDK4 PMC7916426__F1 BA synthesis and transport pathway ATP8B1 FGF8A CYP7A1 FGFR4 PC PMC8430485__F2 Immune-Checkpoint Inhibitors for Metastatic Colorectal Cancer: A Systematic Review of Clinical Outcomes EGF CD80 EGFR MTOR VEGFA PMC8647629__F1 The Renin–Angiotensin System in the Cancer Stem Cell Niche ATR COX2 CTNNB1 PMC2688381__F4 Azithromycin Treatment Alters Gene Expression in Inflammatory, Lipid Metabolism, and Cell Cycle Pathways in Well-Differentiated Human Airway Epithelia ACSS2 EBP FADS2 STARD4 ACACA PMC8500019__F3 Endothelial activation, dysfunction and immunothrombosis in COVID-19 TF TFPI ACE2 PMC10942463__F10 Nucleotide metabolism associated with purine and pyrimidine pathways RRM1 IMPDH1 NDP PMC5410568__F1 The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases BAX ATF4 EIF2A TRAF2 PMC4414306__F5 IGFs/PI3K/Akt signaling pathway analysis using Ingenuity Molecule Activity Predictor (MAP) TSC2 BAD PDE3B TSC1 IGF1 VAMP2 PTEN MTOR IGF2 EIF4E PMC12106402__F1 Metabolite 2-aminoadipic acid: implications for metabolic disorders and therapeutic opportunities GCDH DHTKD1 AASDH AADAT AASS PMC4414306__F4 Growth hormone signaling pathway analysis using Ingenuity Molecule Activity Predictor (MAP) STAT3 STAT1 CEBPA A2M IGF2 IRS1 PMC4418918__F6 Translational effects of Stat1 STAT1 EIF4E PMC3402097__F4 Lineage-specific and ubiquitous biological roles of the mammalian transcription factor LSF CDK6 CDK2 CDK4 PMC8332857__F5 ZNF217: the cerberus who fails to guard the gateway to lethal malignancy ERBB3 BAX BAD ZNF217 MDM2 ERG PMC2667897__F1 TGFB superfamily signaling: notes from the desert EGF NUP214 SMURF1 GRB2 SRC SKI PMC10647460__F7 Regulatory mechanism of cis-9, trans-11 CLA on milk fat synthesis HMOX1 PPARG ATG5 PMC8611103__F3 Disease-specific interactome alterations via epichaperomics: the case for Alzheimer’s disease RHO PMC7952440__F1 miRNAs flowing up and down to facilitate keratinocyte hyperproliferation TIMP3 USP2 PTEN IL1B PMC3836193__F1 Role of apoptosis in colon cancer biology, therapy, and prevention BAX FAS PMC5755720__F1 ERBB signaling in CTCs of ovarian cancer and glioblastoma ERBB3 STAT3 EGF JUN ERBB4 ERBB2 PTEN GRB2 MTOR MYC PMC12056003__F7 IFITMs on CHIKV infection in human dermal cells STAT1 STAT2 IFNAR2 IRF9 IRF3 IRF7 TYK2 PMC4586487__F6 PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells PTBP1 SFRS3 PMC7226765__F9 Overexpression of GRP78/BiP in P-Glycoprotein-Positive L1210 Cells is Responsible for Altered Response of Cells to Tunicamycin as a Stressor of the Endoplasmic Reticulum ELF2 ATF4 XBP1 PMC5409837__F8 High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity with Human Induced Pluripotent Stem Cells IGF1 INSR PDGFRA PMC4177985__F1 LD-Aminopterin in the Canine Homologue of Human Atopic Dermatitis: A Randomized, Controlled Trial Reveals Dosing Factors Affecting Optimal Therapy DHFR TYMS PMC8455910__F10 Gardenoside Hinders Caspase-1-Mediated Hepatocyte Pyroptosis Through the CTCF/DPP4 Signaling Pathway CTCF NLRP3 DPP4 PMC3075605__F2 NFKB signaling pathways downstream of TNFR1, TLR4 and TCR/CD28 TRADD TAB3 IRAK1 TRAF6 IRAK4 MYD88 MAP3K7IP1 BCL10 TLR4 USP21 TRAF2 CYLD LCK PMC12056003__F4 Genes modulated by the expression of IFITM1, 2, and 3 in HFF-1 cells TBK1 TRADD MAVS TANK IFIH1 TLR9 IRAK1 TRAF3 TRAF6 MYD88 NCAM1 STAT1 BCL10 TLR8 MX1 TLR7 IFNA1 CYLD TBKBP1 IFNLR1 STAT2 IRF9 IRF3 IRF7 IFNA2 TNF MAP3K7IP1 TRIM25 TLR3 IFNAR2 IFNAR1 MAP3K7 JAK1 MAP2K1 DDX3X TYK2 CARD9 PMC4128340__F3 Canonical non-Smad pathway tumor growth factor (TGF)B signaling PDPN EHD2 STAT3 TNC MMP14 ZYX NRP1 EMP3 PML SMAD4 PLA2G5 FLNA CA12 PI3 OSMR FCGR2C CD151 COL4A2 THBD HRH1 ACTN1 SLC67A1 EFNB2 IFITM2 ITGA7 LIF PLAUR NRP2 PDLIM4 HOMER3 TPP1 EMP1 CEBPA RUNX1 STEAP3 PELO MVP ECE1 SGSH DKFZp686P11128 OSBPL3 GRB2 PMC7306774__F7 Proposed mechanism for CRY’s effect on susceptibility to stress-induced depression-like behavior PER2 FOS PMC4414306__F7 NRF2-mediated oxidative stress response RYR3 TXN AOX1 PPIB KEAP1 MSMO1 OSTN MAF PKIA EN1 PSAT1 GHR PMC7161485__F1 ADE and antibody mediated immunopathology. Left panel: For ADE, immune complex internalization is mediated by the engagement of activating Fc receptors on the cell surface STAT1 HEL-S-62p C4B_2 PMC5932566__F2 Molecular and signaling impact of MUC5AC in various malignancies CDH2 MMP7 MUC5AC MMP3 VEGFA CXCL8 CTNNB1 PMC7122041__F9 Coagulation profile of endothelial surface during normal (left panel) and activated state (right panel) TF TFPI APC PLG PC PMC4422082__F4 CD44- and CD44v-induced RTK for apoptosis resistance HGF COX2 VAV2 ERBB2 CDC37 GRB2 SRC PMC7426366__F3 Action of ceramide on insulin signaling and glucose metabolism in muscle cells CERS1 FGF21 IRS1 PMC10382901__F5 Genetic alterations in MED12 promote castration-resistant prostate cancer through modulation of GLI3 signaling POR GLS GLI3 PMC10912719__F2 DNPNB pathway PURA PAICS FH GLA PURB HEL-S-70p ADSL PMC9001080__F3 Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals RBX1 KEAP1 GCLC PMC8523568__F3 Extracellular calcium alters calcium-sensing receptor network integrating intracellular calcium-signaling and related key pathway RAB5C UGGT1 CANX HEL-S-269 GANAB STUB1 CASR TMCO1 VAPB VAPA RAB18 MCU SPTLC1 CLTC PMC3923981__F7 Cytosolic Functions of MORC2 in Lipogenesis and Adipogenesis ACLY FAS MORC2 PMC7426366__F1 Metabolism of sphingolipids CERK SMS KDSR PMC10912719__F7 Regulation of DNPNB enzyme clustering and purinosome assembly-disassembly under the control of regulatory proteins and signaling pathways PAICS HEL-S-70p ADSL PMC3989821__F2 Prostate smooth muscle contraction and assumed connections to the regulation of prostate growth RHO PMC11016731__F3 Rationale for immune checkpoint inhibitors plus targeted therapy for advanced renal cell carcinoma ZAP70 APC MSC MTOR VHL PMC11016731__F2 Mechanism of tumor cell genesis induced by hypoxia inducible factor (HIF) EPO MTOR VHL PMC6513836__F7 Brief summary of the possible mechanisms of KSHV-mediated pathogenesis at the cellular level IL10 SMAD1 FAS CDK6 IL18 IL6 HES1 NOTCH1 PMC4023701__F5 Crosstalk pathway PLA1A TNC CALD1 RECK SPARC CCL2 CTSG PCSK9 SLIT3 SLIT2 MME COL1A1 CLU FGFR4 ISG15 CD81 IGDCC4 SERPING1 SELE LIF ROR2 CFH VEGFA RELN SPP1 MYOC FGF7 ITGA1 LAMA4 SDC2 SDC3 PF4 PMC9476726__F11 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer DLL4 DLL3 PMC3241422__F8 Mpk1-driven FKS2 transcription ROM1 PMC9476726__F10 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer LTA MAP3K7IP1 CD14 TRAF6 LBP MYD88 PMC4534763__F6 Identifying miRNA/mRNA negative regulation pairs in colorectal cancer RAD21 CDK7 PCNA E2F4 CDC6 SMAD2 SMAD4 CDK2 ORC3 PLK1 SKP2 PMC5915111__F10 Signaling pathways in the glaucomatous trabecular meshwork BAMBI SMAD1 TLR4 SMAD4 PMC4534763__F4 Identifying miRNA/mRNA negative regulation pairs in colorectal cancer NRG2 HBEGF JUN BAD CBL BTC NRG3 GRB2 MTOR SHE NRG4 PMC6163961__F4 Apoptosis inhibition in cancer TGFBR2 BAX BAD TGFBR1 PMC3856408__F1 Endogenous small RNA pathways involved in host defense and viral pathogenesis in plants and animals AGO4 DGCR8 AGO1 AGO2 DROSHA PMC6163961__F1 Apoptosis extrinsic and intrinsic (mitochondrial) pathways BAX DCC BAD FAS CAD PPA2 FADD PMC6163961__F2 Apoptosis intrinsic (endoplasmic reticulum (ER)) pathway BAX ATF4 EIF2A XBP1 TRAF2 PMC4613518__F1 Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention HMOX1 RBX1 KEAP1 GCLM MAF AKR1C1 PMC6389897__F2 Folate metabolism is linked to the homocysteine metabolic pathway VIT HEL-S-61p PMC5138253__F5 Different roles of Gq- and Gs-coupled GPCRs expressed by AgRP neurons in food intake CA11 NPY AgRP PMC12009754__F8 Graphical abstract of the study FKBP5 APC CTNNB1 PMC8767067__F4 Aberrant Expression of miR-1301 in Human Cancer KLF4 CDH2 STAT3 BAX UBE4B PCNA GSK3B SOX2 EZH2 EIF5 VEGFA AXIN2 SFRP1 CTNNB1 RHEB CD44 MYLK BCL9 RUNX1 MMP2 CDK2 ATG5 PMC2728081__F2 Regulation of B-cell entry into the cell cycle SYK BCR PI3 LYN PMC6224214__F8 Liver X Receptor (LXR) pathway as the result of the integration between transcriptomic and metabolomic data APOA4 HMGCR PMC2981059__F6 HER/HER2-PI3K-Akt-NFKB-elicited pathway in prostate cancer cells EGF RELA PTEN PMC8948514__F1 Case series of cerebral venous thrombosis as the first manifestation of homocystinuria HEL-S-61p PMC8626127__F8 Ovalbumin antigen-specific activation of human T cell receptor closely resembles soluble antibody stimulation as revealed by BOOST phosphotyrosine proteomics CD3D ZAP70 NCK1 LAT PTPRC FOS PLCG1 ITK MAPK12 GRB2 CD3G CD3E LCK PMC6838365__F40 Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3B/Beta-catenin signaling pathway MAP2K4 MYH9 GSK3B TRAF6 CTNNB1 PMC11906485__F1 Biosynthetic pathway of plasmalogens and RCDP types based on gene mutation AGPS PEX7 FAR1 PEX5 PMC6111868__F7 Signalling pathway by which kallistatin inhibits endothelial senescence, oxidative stress and inflammation VCAM1 SIRT1 HEL-S-44 PMC6105545__F6 Persistent EcoHIV infection induces nigral degeneration IFNG IL10 TLR4 HEL-S-162eP NFKB1 CCR7 IL5 SRC CCL2 IL9 PMC7811275__F3 Regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis) CASP8 MAVS MLKL IRF9 IRF1 IRF3 RIPK3 GSDMD CASP6 ZBP1 NLRP3 IFNAR2 IFNAR1 CASP3 RIPK1 FADD PMC2782690__F3 Is cancer a disease of abnormal cellular metabolism? F2 TIGAR MYC CIT PMC5938286__F2 PD-1/PD-Ls signaling pathway ZAP70 APC MTOR PMC5940272__F1 Alternative pathways of type I IFN induction during M TBK1 CGAS TLR4 NOD2 IRF3 PMC5938286__F1 Illustration of cross-communication network of BCR, PI3K, apoptosis, and NFKB signaling pathways CD40 BAX SYK TRADD CARD11 RELB PTEN MTOR TNF MYC MYD88 BTK CDA BCL10 BCR RELA BCL2 MDM2 BCL6 FADD PMC3256223__F1 Modeling of miRNA and Drug Action in the EGFR Signaling Pathway EGF BAD EGFR PMC4389797__F7 Schematic showing the TGFB/LIF- mediated tumor suppressive role in melanoma STAT3 BAX SMAD2 LIF SMAD4 PMC5938286__F3 Illustration of JAK/STAT signaling pathway BCL2 MTOR SRC MYC PMC3742001__F7 Schematic diagram summarizing the signaling pathways relevant to this study TSC2 TSC1 GRB2 PMC8928136__F4 Signaling pathways by DJ-1: An updated overview TRAF6 TRAF2 PMC8928136__F3 Signaling pathways by DJ-1: An updated overview FIS1 RNF5 PTEN PMC8928136__F5 Signaling pathways by DJ-1: An updated overview BAX CASP6 SIRT1 PMC5515553__F1 Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells PRLR STAT3 PRL LIF JAK1 PMC8928136__F2 Signaling pathways by DJ-1: An updated overview BMF DDC HEL-S-44 PMC6514318__F1 Molecular genetic pathways in long-term epilepsy-associated tumors (LEATs) and pediatric type diffuse low-grade glioma (DLGG) EIF4B SGK1 ULK1 BRAF PTEN DEPTOR IRS1 EIF4E ATG101 RHEB TSC2 TSC1 NF1 FGFR1 PMC3700727__F1 The Aryl Hydrocarbon Receptor: A Novel Target for Immunomodulation in Organ Transplantation TF AHR CYP1B1 CYP1A1 PMC7494983__F5 Epigenetic modification and therapeutic targets of diabetes mellitus EBP TNF IRS1 PMC5760518__F5 Signaling pathway activated by piperonylic acid STAT3 EGR1 EGFR PMC8884172__F10 Downregulation of Three Immune-Specific Core Genes and the Regulatory Pathways in Children and Adult Friedreich's Ataxia: A Comprehensive Analysis Based on Microarray FAS PMC9262990__F14 Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer WAS MTOR TNF IRS1 PMC7594527__F1 Lipid metabolic pathway in S LPA PDC PC SI PMC9168369__F1 Novel 1,2,3-Triazole Erlotinib Derivatives as Potent IDO1 Inhibitors: Design, Drug-Target Interactions Prediction, Synthesis, Biological Evaluation, Molecular Docking and ADME Properties Studies ID2 HEL-S-90n IDO1 KYNU KMO IDO2 PMC3489783__F3 Representative KEGG pathway change of Endocytosis EHD2 F2 VPS25 EGFR ARF6 LDLR KIN CHMP3 VPS36 PMC12150572__F8 Role of CIP2A in OA cartilage CIP2A KY CEMIP REL PMC3766957__F2 Cancer metabolism: fatty acid oxidation in the limelight UCP2 BAX UCP3 FASN PC CPT1C ME1 HEL-S-26 PMC8156589__F1 Diabetic Retinopathy and NADPH Oxidase-2: A Sweet Slippery Road TET2 RAC1 PMC8532171__F6 Flg22- and D-glucose-biased signaling CLC FLOT1 BAK1 PMC6480114__F1 Proposed mechanical cues regulates Hippo signaling pathway in gastric tumorigenesis LATS1 ARHGAP20 LATS2 AMOT GC RHO SRC MYC ARHGAP29 YAP1 CTNNB1 PMC2647614__F2 Novel Insights into Lung Transplant Rejection by Microarray Analysis IL2RB THBS1 IL4 VTN IL2RA IL2 IL5 SET LCK PMC9489610__F5 Necroptotic signaling mechanisms and outcomes in ALS RIPK3 TBK1 CASP8 MLKL RIPK1 OPTN FADD HEL-S-44 PMC3576254__F5 Pathway analysis MAX REST JUN FAS LEP NF1 MAK APC PC DAO FLNA PMC8064146__F5 Transcriptome and lipidome profile of human mesenchymal stem cells with reduced senescence and increased trilineage differentiation ability upon drug treatment SGMS1 SCD CDS1 LPCAT3 PC ENPP7 PISD PMC9489610__F3 Evidence for activation of apoptosis in ALS MAX FUS BAX CASP9 TBK1 BAD MCL1 CASP3 BCL2 RIPK1 BOK C9orf72 PMC186326__F7 Model for Fgf18 regulation of long bone growth FGFR1 IHH FGFR3 SMO FGF18 FGFR2 PMC7139751__F1 Akt signaling pathway RHEB MLST8 TSC2 BAD RICTOR TSC1 PI3 TBC1D7 PTEN MTOR DEPTOR PMC10384200__F4 Association between High Interferon-Gamma Production in Avian Tuberculin-Stimulated Blood from Mycobacterium avium subsp. paratuberculosis-Infected Cattle and Candidate Genes Implicated in Necroptosis HMGB1 OSM H2AX MLKL IL33 IRF3 TRAF3 TNF POR RIPK3 PYGL LOX FES USP21 CYLD FADD PMC3208682__F1 Expression patterns of the TLR signaling pathway in CLL HEL-S-31 CD80 TBK1 TIRAP IRAK1 IRAK2 TRAF6 IRAK4 MYD88 IFNG BTK RIPK2 MAP2K4 TICAM1 CHUK IFNA1 MAP2K3 ECSIT IL10 JUN IL12A TICAM2 CD14 SIGIRR IRF3 TNF FOS MAP3K7IP1 MAP3K1 NFKB1 RELA IKBKB NFKBIA MAP3K7 PMC3094730__F2 Dendritic cell control of tolerogenic responses SOCS1 SOCS3 FOXP3 PMC6676383__F5 Metabolic pathway map showing fold changes of leaf metabolite concentrations of Plantago lanceolata subjected to different precipitation and temperature treatments MAL CIT PMC8862784__F2 ACE2: a key modulator of the renin-angiotensin system and pregnancy NQO1 TNF ACE2 IL1B PMC7104985__F2 Broad depiction of the endoplasmic reticulum (ER) stress-driven unfolded protein response (UPR) signaling ATF4 EIF2A TRAF2 PMC7104985__F1 Schematic depiction of production and sensing mechanisms for type I interferons (IFNs) STAT3 TBK1 CGAS MAVS STAT2 TLR9 IRF3 IRF7 MTOR IRS1 STAT1 TLR3 TLR4 TLR8 STAT4 TLR7 JAK1 TYK2 PMC6125320__F7 The molecular mechanisms underlying the role of mTOR/p70S6K/HIF-1A signaling pathway in the regulation of TLR4 inflammatory signaling and TH17 cells in liver IRI ATF3 TLR4 TRAF6 PMC11003953__F3 Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic FFAR3 BDNF FFAR2 PMC11003953__F2 Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic TGFB1 PYY GDNF BDNF PMC9699542__F4 Mitophagy Induced by Metal Nanoparticles for Cancer Treatment PINK1 HIF1A MTOR PMC3836169__F1 PTEN in cancer, metabolism and aging MLST8 IGF1 FOXO1 FOXO3A F3 IRS1 PMC83901__F8 Model of the regulation of class II MHC genes by IFNG IFNG STAT1 MHC2TA JAK1 PMC9146539__F1 Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Disease DRD2 RAB5A ANXA2 SNCA PMC10893548__F7 NMN promotes hair growth by regulating the paracrine system of cells IL1B CTNNB1 PMC9489610__F1 Immunological outcomes of apoptosis versus programmed necrotic mechanisms XKR8 VTN ATP11C MERTK PMC2013861__F4 Signalling pathways activated by the RXFPs RXFP3 EGFR RXFP4 SRC RXFP2 PMC4889216__F7 Mitochondrial stress induces chromatin reorganization to promote longevity and UPRmt ME3 ME2 ME1 PMC6843654__F4 Top three molecular networks identified by Ingenuity Pathway Analysis (IPA): (a) Network 1 NCAM2 SMAD1 LAMA1 CTSH SPARC CTSS EPYC HCN4 MYLK PROS1 TTN CHEK2 NF2 NR1A2 NKTR SETX ESPL1 SGTB CRKL OBSCN MOGAT2 STRN TACC2 SPRED1 PTPRE RNF20 B4GALT4 PMC7983894__F4 Oxidative stress leads to multiple death modalities through various pathways in melanocyte RIPK3 SIRT3 HMGB1 GSDMD TRPM2 NLRP3 KEAP1 MLKL RIPK1 MIF AIFM1 PARP1 PMC7568049__F1 SARS-CoV-2 infection pathway in humans and COVID-19 progression TG PC ACE2 PMC5344271__F3 Upon SV40 infection of mesothelial cells, Tag (Large T) and tag (small t) antigens are expressed HGF IGF1 EGFR IGF1R NOTCH1 PMC6668073__F4 Hedgehog signalling and SMO inhibitors action in MB PTCH2 SUFU PTCH1 SMO GLI3 PMC6327307__F3 Epigenetic control of CD8+ T cell differentiation TF BRD4 CDKN2A FBXW7 BATF FOXO1 KLRG1 PRC1 NUMB SIRT1 PMC6327307__F2 Epigenetic control of CD8+ T cell differentiation DNMT3B GC PMC6222347__F7 Suggested mechanism of action of morusin in MDI-stimulated 3T3-L1 cells and primary adipocytes CEBPA FAS EPO PMC3800035__F7 Heterotrimeric G-Protein, GA16, Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer ROR1 WNT3A ROR2 WNT7A LRP6 CTNNB1 PMC6434253__F2 Sub-pathways identified using the sub-pathway strategy JUN SHC1 GNB2 EGFR AKT3 YLPM1 MTOR MYC KRAS ERBB3 CHUK NRAS LYN PLCB3 GRB2 ZNF71 ZNF76 PMC4839264__F7 mTOR signaling in ALK+ ALCL oncogenesis RPS6 RICTOR ALK MTOR EIF4E PMC3070842__F1 Lessons on transcriptional control from the serum response network IFNG EGR1 HMGN1 FOS PMC2860379__F2 Genes affecting dystroglycan glycosylation associated with congenital muscular dystrophy POMT2 POMT1 FKRP PMC2684977__F2 Biologic actions of isoprenoids BMP2 ARHA RAC1 PMC4496162__F3 MicroRNAs in apoptosis, autophagy and necroptosis RHEB MLST8 TSC2 BAD TSC1 ATG12 ELF2 BNIP3 PTEN MTOR EIF2A PMC5388243__F7 Schematic of the proposed mechanism of MIR506 induction of autophagy-related cell death in PDAC cells through the STAT3 signaling pathway STAT3 BCL2 PMC8478810__F2 Wnt pathway: an important control mechanism in bone’s response to mechanical loading LRP4 SOST DKK1 LRP5 PMC8478810__F4 Wnt pathway: an important control mechanism in bone’s response to mechanical loading RNF43 LRP5 ZNRF3 GPR49 RSPO1 LGR6 PMC4496162__F4 MicroRNAs in apoptosis, autophagy and necroptosis TRADD TLR3 PGAM5 MLKL HEL-S-11 CYLD TRAF2 FADD PMC7968933__F2 Mechanisms through which biological sex could affect BBB integrity TIMP1 ROCK2 SP1 CCR2 ANXA1 VCAM1 ARHA RHO PMC5867300__F1 Immune modulatory signaling in antigen-presenting cells (APCs) induced by binding of interleukin-10 (IL-10) to the IL-10 receptor GAA STAT3 IL13 SOCS3 IL10RA JAK1 TYK2 IL1B PMC5659283__F2 PTEN controls the G2-M transition to prevent bypass of the G2 checkpoints and premature entry into mitosis (M) CDC2 ATR CHFR PTEN CCNB1 TOP2A PMC6938687__F2 The RTK-PI3K-AKT-mTOR signaling pathway RHEB IGF1 CCND2 PI3 AKT3 NPRL2 TBC1D7 C16orf35 DEPDC5 IGF1R MYC DEPTOR PMC6752985__F1 PI3-K/Akt signaling pathway TSC2 CDK2 PTEN PMC7168269__F1 Roles of gastric cancer stem cells (GCSCs) in the immune microenvironment STAT3 CXCL12 SMAD2 PMC4127596__F2 Beclin 1, its protein interactions and its role in autophagy HMGB1 MAP3K7IP1 PINK1 VMP1 UVRAG AMBRA1 TRAF6 PMC4127596__F1 Autophagic process and some of its major regulators RHEB TSC2 TSC1 ATG12 ULK1 ATG5 IRS1 PMC10302309__F2 Resistance to EGFR-TKIs in Non-Small Cell Lung Cancer: From Molecular Mechanisms to Clinical Application of New Therapeutic Strategies ROS1 EGFR BRAF PTEN MTOR KRAS RB1 CDK6 ALK CCNE1 CCND2 NTRK1 CCND1 RET CDK4 PMC3742652__F4 Proposed Twist2 involvment in ovarian cancer BAD BCL2 TWIST2 PMC7643212__F4 Tumor necrosis factor receptor-associated factor 1 pathways involved in T cell survival FOXO1 JAK3 TRAF1 PMC8074086__F1 Mycosis Fungoides and Sézary Syndrome: An Integrative Review of the Pathophysiology, Molecular Drivers, and Targeted Therapy STAT3 CARD11 JAK3 ARHA GATA3 STAT1 PLCG1 CCL19 STAT5B CCL21 CCR7 CCR4 STAT4 FOXP3 JAK1 PMC8274420__F4 Novel Prognostic Biomarkers in Metastatic and Locally Advanced Colorectal Cancer: Micronuclei Frequency and Telomerase Activity in Peripheral Blood Lymphocytes EGF EGFR SMAD2 APC SMAD4 TERT PTEN HIF1A MTOR CTNNB1 PMC3884931__F1 Mammalian target of rapamycin (mTOR) signaling pathway regulation RHEB EGF TSC2 NGF PMC2755790__F1 Network analysis of differentially expressed proteins (red symbols) involved in arteriogenesis EFNB2 NOS2 JUN ABRA HEL32 ARHA PMC8478810__F1 Wnt pathway: an important control mechanism in bone’s response to mechanical loading APC GSK3B LRP5 PMC5309878__F3 Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients LPA LPCAT4 LPCAT2 LPCAT3 PEMT PC LPCAT1 IL1B PMC9304626__F1 Oxidative Stress and Lipid Peroxidation: Prospective Associations Between Ferroptosis and Delayed Wound Healing in Diabetic Ulcers GPX4 SLC7A11 HEL-S-64p PMC5006924__F7 IL-10-producing B cells induced by TRAPs MYD88 PMC8138659__F2 Nkx3.1 in Cancers and Stemness KLF4 STAT3 SOX2 PMC9181656__F2 Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance STAT3 CCR2 CCL2 NOTCH1 PMC4142215__F1 Genome wide proteomics of ERBB2 and EGFR and other oncogenic pathways in inflammatory breast cancer EGF JUN BAD CBL ERBB4 BTC MTOR SHE PMC5581331__F2 P53 and pRB pathways during senescence CDK6 CDK2 MDM2 CCND1 CDK4 PMC11956214__F8 Cell cycle signaling and key proteins PCNA MAL CDK2 CYC1 ME1 PMC8301816__F2 Epithelial Protein Lost in Neoplasm, EPLIN, the Cellular and Molecular Prospects in Cancers STAT3 EGF IGF1 EGFR IGF1R SRC CTNNB1 PMC12153268__F7 The mechanism of LAG3 inhibition of IFNG production by NK cells IFNG STAT1 HK2 PSAT1 MTOR MYC LAG3 PMC5662495__F2 Mitochondrial Ribosomes in Cancer BAX TNF FADD PMC8601163__F1 Auxin‐mediated induction of GAL promoters by conditional degradation of Mig1p improves sesquiterpene production in Saccharomyces cerevisiae with engineered acetyl‐CoA synthesis GAL IPP GPD1 PMC3576161__F1 Folate metabolic pathway FOLH1 MTRR MTR PMC4774966__F5 Tolerant and Susceptible Sesame Genotypes Reveal Waterlogging Stress Response Patterns PPIC EN2 ERFL ECD PMC3022058__F1 Outline of UDP-GlcNAc synthetic pathways OGT GNE PMC1083933__F2 Cell cycle trials in Salamanca CDC2 MOS MYT1 CCNB1 PMC2293256__F4 Reannotation processes NNAT MTAP NADK PMC3888285__F2 Liver responds to iron signals to regulate hepcidin production BMP6 SMAD1 TFR2 DKFZp781O1323 SMAD4 HFE ID1 HFE2 PMC5876067__F2 Inhibition of the BRCA1 DNA damage response pathway indicated by a down modulation (green; up-modulation is indicated in red) of atm, brip1, cdkn1a, e2f3, fancd2, fancl, mdc1, rad51, and rpa1 in male X ATM ATF1 SHE MDC1 PMC5131788__F2 Molecular mechanisms underlying alcohol-drinking behaviours HRAS GDNF PER2 NF1 PER1 PDYN NPY BDNF DRD3 RET PMC5540801__F4 Shh pathway targets and regulatory networks ETV5 ETS2 HHIP BOC PRDM1 GAS ALX4 HAND2 SALL4 PTCH1 BMP4 ETV4 BMP2 SHH TBX3 SMO PMC7816003__F1 Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1A signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats UCP2 TFAM NRF1 PMC8968515__F9 Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis ADM MTOR PMC5876695__F6 Meta-network illustrating synergistic interventions and resistance mechanisms to PI3K inhibitors FOXA1 BAD SGK1 FOXO3A MLL2 PBX1 CDK2 BCL2 MYC PMC7268490__F1 Schematic diagram of experimental workflow REN PLAT PMC5876695__F3 Network model of oncogenic signal transduction in ER+ breast cancer FOXA1 BAD CDK6 SGK1 FOXO3A MLL2 CDK2 BCL2 PTEN MYC CDK4 PMC9358906__F6 Type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway STAT1 WWTR1 STAT2 IFNAR2 IFNAR1 AMOTL2 IRF3 JAK1 TYK2 PMC11208122__F12 Scutellarin alleviates microglia‐mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3B signaling pathway BAX CD19 JAK1 PMC8767413__F4 Assessing the Potential Value and Mechanism of Kaji-Ichigoside F1 on Arsenite-Induced Skin Cell Senescence EGF CEBPB PMC4508501__F3 Altered steps in miRNA biogenesis lead to cancer XPO5 DICER1 TARBP2 DROSHA PMC7795003__F2 IGF-1 receptor, insulin receptor and hybrid receptor IGF1 IGF1R MTOR PMC4508501__F1 miRNA biogenesis process XPO5 AGO2 DROSHA PMC7795003__F1 Growth hormone (GH) receptor IGF1 PMC7795003__F3 Interplay of GH, IGF-1, insulin, hybrid receptor and nutrients in the muscle IGF1 MTOR SLC38A9 PMC8105775__F2 Caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems TH NPS SLN PMC8852737__F4 Synthesis and Antitumor Evaluation of Menthone-Derived Pyrimidine-Urea Compounds as Potential PI3K/Akt/mTOR Signaling Pathway Inhibitor HEL-S-22 AURKA PPARG PGR EGFR JAK3 PIK3R1 TYMS CCNA2 MAPK8 PLA2G2A TGFBR1 FGFR2 MAPK14 ALB RARA BCL2L1 INSR NR3A2 FGFR1 MMP2 IL2 ITK KDR MDM2 SRC MAPK1 NR1i1 ERBB4 HEL-S-7 PTPN11 BST1 KIT MMP9 PARP1 HRAS GSTM1 IGF1 CASP3 CHEK1 BMP2 CDK2 MAP2K1 CTNNA1 NQO2 PMC5840040__F3 Thermodynamic description of the eIF2B catalytic cycle ELF1 SUI1 ELF2 GIP PMC7753017__F4 Four pillars of sarcoidosis model TREM1 CD14 ATM MTOR PMC8511144__F7 Phenylephrine increases tear Cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway LAMP2 RAB27A RAB27B RAB3D PMC6981390__F2 The biosynthetic pathways (terpenoids, bitter acid, phenylpropanoids and flavonoid) in the hop IPP BCAT1 STS PMC11006979__F2 Unveiling the impact of CDK8 on tumor progression: mechanisms and therapeutic strategies CDK8 STAT1 SMAD4 CDK9 PMC7179464__F1 Macrophage migration inhibitory factor (MIF) and cancer pathway CD44 BAX BAD CD74 MIF IL8RB CXCR4 PMC8147889__F3 Mechanisms of HBV-Induced Hepatocellular Carcinoma STAT3 KEAP1 APC LRP5 LRP6 PTEN IRS1 CTNNB1 FOXO1 MAF GRB2 GAB2 CCND1 PMC9508091__F2 Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma OGT GNPNAT1 PMC9508091__F1 Mutant KRAS mediated metabolic alterations GLUD1 GLS HEL-S-133P ME1 PMC8196151__F3 Phosphoproteome analysis with equal loading TMT11 provides a comprehensive overview of cancer-relevant pathways CASP9 BAD EGFR GSK3B BRAF RBL2 PTEN CD19 MTOR DSG3 MYC RAC1 ARAF BRCA1 BCR NQO1 RXRA NKX2-1 TP63 NFE2L2 ERBB2 MDM2 CCND1 PMC9086968__F6 14,15-Epoxyeicosatrienoic Acid Protect Against Glucose Deprivation and Reperfusion-Induced Cerebral Microvascular Endothelial Cells Injury by Modulating Mitochondrial Autophagy via SIRT1/FOXO3a Signaling Pathway and TSPO Protein UBE3A PPARG MYOD1 PPIF SMAD2 CRY1 FOXO1 FOXO3A PBR EP300 PPARGC1A MDM2 SUV39H1 SIRT1 PMC7666984__F1 TLR4 signaling pathway (schematic) TIRAP TLR4 CD14 IRF3 IRF7 TRAF6 LBP MYD88 PMC4456452__F17 Pathway model for fly-wasp mediated social learning AMN FMR1 PMC9107748__F3A Transcriptome profiling and proteomic validation reveals targets of the androgen receptor signaling in the BT-474 breast cancer cell line BARD1 ERBB4 MYC SET PMC6232868__F1 Schematic representation correlating various factors such as light, eye, melanopsin, pineal gland, vitamin D, intestinal calcium, and gut microbiota to neuroinflammation and MS TLR4 CD14 TNF PMC2042178__F2 PTEN/PI3K/mTOR/STAT3 signaling involved in breast cancer stem-like cell survival and proliferation STAT3 PTEN MTOR PMC5365005__F6 Sclareolide pathway enhances gemcitabine-induced gemcitabine-resistant human pancreatic cancer cell death RRM1 TWIST1 PMC9047489__F1 Epithelial-Mesenchymal Transition-Inducing Factors Involved in the Progression of Lung Cancers FOXC2 SMAD2 GSK3B PMC8980082__F4 LncRNAs in the regulation of pyroptosis in NSCLC GSDMD NLRP3 TLR4 RELA IL18 MYD88 PMC8980082__F2 LncRNAs participate in the regulation of the apoptotic pathways in NSCLC BAX BAD TRADD BCL2 FADD PMC12024087__F9 Bta-Let-7d Modulation of Oxidative Stress Induced by Potassium Permanganate in Bovine Endometrial Cells via IGF1R/PI3K/AKT Signaling Pathway BAX BCL2 IGF1R MTOR PMC5295493__F2 Dietary triglycerides as signaling molecules that influence reward and motivation TG NGF ANKK1 PMC3165056__F4 Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity TRADD IRF3 IRF7 TRAF3 TRAF6 TRAF2 FADD PMC8027411__F9 RAB31 marks and controls an ESCRT-independent exosome pathway RAB31 TBC1D28 CD63 TBC1D2B PMC3589543__F7 A pathway choice model for repair of a DNA DSB in Arabidopsis SMC6 SMC5 PMC6160413__F6 Impact of osmotic stress on central carbon metabolism HEL60 GPD2 ACO2 ENO2 HEL-S-49 FBP1 MDH2 GPD1 TIA1 CIT PMC5651906__F8 PTP4A1 promotes TGFB signaling in DFs PTP4A2 PTP4A1 SMAD4 SRC PMC7216742__F3 Fyn signaling pathway STAT3 FYN ULK1 ATG14 PMC4586096__F1 G2E3 attenuating replicative stress RAD18 ATR PCNA G2E3 PMC5070123__F3 Major pathways affected in cancer- and drug-induced cachexia MYLK2 EHD2 TMOD1 HEL-S-273 ETFB MYH6 SNTA1 ACTN2 ACADM TPM1 PYGL ETFA COX2 TPM3 PRELP ACTN1 PYGM FBN1 MYBPH AMPD1 ASPN PYGB ACADS KRT82 MYH1 KRT81 JPH1 KRT85 OBSCN FABP4 COPA MYOZ3 TMOD4 KRT35 PURA HEL-S-71 MYOM1 JPH2 ACSL1 GYS1 PLEC CASQ1 ACADL HEL-S-87p FITM1 LMNA PMC7492772__F3 NRX-based and LAR-RPTP-based synaptic organizing complexes display contrasting AB sensitivity ABO BACE1 APP LRRTM3 NLGN1 PMC10571814__F8 Oxytocin signalling pathway, with yellow boxes representing proteins identified in this study and green circles representing metabolites identified in this study RGS2 RNF123 MYOT EGFR BRAF MEF2C MYL6B EEF2K MYL1 MYL3 COX2 DCLK1 MYL2 CACNB3 SRC CCND1 RCAN1 OXT TNNC1 TNNC2 MYOF PLA2G4E OBSCN ARHA MYL11 TRPM2 EEF2 CDKN1C MAP2K1 GFM1 PLA2G4B MYL4 PMC8228963__F8 Foxtail Millet Improves Blood Glucose Metabolism in Diabetic Rats through PI3K/AKT and NFKB Signaling Pathways Mediated by Gut Microbiota FAS TNF IL1B PMC8834311__F5 Endocrine Fibroblast Growth Factors in Relation to Stress Signaling FGF8A FGF21 ATF2 FGF23 PMC8834311__F4 Endocrine Fibroblast Growth Factors in Relation to Stress Signaling FGF21 ATF4 EIF2A FGF23 PMC9124765__F2 Biomechanical Regulatory Factors and Therapeutic Targets in Keloid Fibrosis SMAD2 SMAD4 ARHA PMC8836129__F4 R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1 WRNIP1 ATR RAD51 ATM PMC7472464__F7 Overview of metabolic reprogramming in adipose tissue in EgPSC infected mice FH ACOD1 HEL-S-5 CS PMC6781720__F1 Schematic overview of the TLR4 signaling pathway TLR4 CD14 IRAK2 TRAF6 LBP IRAK4 MYD88 PMC5190013__F10 Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers MMP7 APC GSK3B LRP5 LRP6 MYC CCND1 CTNNB1 PMC11769711__F2 Canonical Wnt signaling pathway and targeted therapy in AS SOX9 APC LRP5 LRP6 GATA6 CTNNB1 PMC11769711__F1 Canonical and noncanoical TGF‐B signaling pathway and targeted therapy in AS (BMP signaling pathway is not shown) TF SLIT2 FGF21 SMAD2 GDF15 SMAD4 MTOR SIRT2 CD47 SET PMC11895685__F1 Mechanisms and Therapeutic Implications of PI3K Signaling in Airway Inflammation and Remodeling in Asthma TSLP IL13 IL33 IL4 IL2 IL5 TNF IL9 PMC4169059__F2 AC in vascular endothelium KEAP1 COX2 NQO1 VCAM1 SRC PMC7045390__F6 Correlation analysis of the hypoxic transcriptome and metabolome data HEL60 tal-1 ACO2 HEL-S-68p PGM2 HEL-S-49 HEL-S-32 ARG1 ENO1 DPP3 HEL-S-26 PSD2 PMC11758636__F9 Lin28b-let-7 Modulates mRNA Expression of GnRH1 Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells KISS1 LIN28B KCNJ3 MTOR PMC11769711__F4 Mechanistic models of AS POSTN NLRP3 CTGF MYD88 PMC7862327__F3 PI3K–AKT–mTOR signaling cascade and other related pathways involved in FCD PTEN DEPTOR IRS1 EIF4E RHEB HTR6 TSC2 TSC1 INSR PDPK1 NPRL2 C16orf35 DEPDC5 GRB2 PMC11769711__F3 NF‐KB signaling pathway and NLRP3 inflammasome in AS NLRP3 RELA GATA6 TRAF6 HDAC2 MYD88 PMC5753034__F6 DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages CDC2 MCM2 PMC11592033__F1 Image depicts a signaling pathway where neurotransmitters bind to membrane receptors, activating G-proteins and effector proteins to produce second messengers like Ca2⁺ and cAMP JUND FOSB JUNB PMC10145676__F1 Main metabolic pathways related to myo-inositol transformation inside the cell INPP1 IP6K2 IP6K3 IPMK PTEN IP6K1 PMC5572370__F7 Pathways of activation of naïve CD4+CD25+ T regulatory cell (Treg) (tTreg) APC IL5RA FOXP3 PMC3889256__F7 Rsu1 is a critical component for regulation of p38 Map kinase signaling from the IPP complex CDC42 EGF PAK1 RSU1 HEL-S-28 NCK2 PMC7866785__F7 Regulation pathway of CASC19 in the radioresistance of NPC MTOR PARP1 PMC3342364__F2 Molecular mechanisms mediating the regulatory effects of hypoxia NOS2 RECK MSR1 ARG1 TAP1 CCL2 PMC9272703__F4 N-Glycosylation and Inflammation; the Not-So-Sweet Relation MGAT5 TH IF2B1 ST6GAL1 MGAT2 PMC5891174__F3 Crosstalk of DNA double‐strand break repair pathways in poly(ADP‐ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2‐mutated cancer RAD51 BRCA1 BRCA2 RIF1 PMC4283216__F1 GSK-3 family as therapeutic target for myocardial diseases GSK3A SMAD2 APC SMAD6 SMAD4 HEL-S-28 ARHA MYC CTNNB1 PMC5373538__F2 Proteomic characterization of epicardial-myocardial signaling reveals novel regulatory networks including a role for NFKB in epicardial EMT PNOC PTX3 TGFBI PTPRS BPI NAMPT PXDN PTPRK CD99 PMC12052172__F4 Pathway network analysis based on genes annotated in eccDNAs RUNX1 BCR ERBB2 GRB2 RUNX2 RAC1 PMC6627365__F2 Epidermal Growth Factor Receptor-dependent activation of the MAPK signaling pathway EGF EGFR CR2 GRB2 PMC8750246__F1 AGEs-Induced and Endoplasmic Reticulum Stress/Inflammation-Mediated Regulation of GLUT4 Expression and Atherogenesis in Diabetes Mellitus CEBPA AGER DDIT3 XBP1 TRAF2 PMC6525811__F2 miRNAs that indirectly impact Alpha-syn without binding to its 3′-UTR TFEB FGF20 ARHA PMC2396219__F2 PPARA and AMPK activities in the cancer cells exposed to energetic stress RHEB TSC2 BAD NR1C1 TSC1 MDM2 MTOR IRS1 PMC4967820__F2 Gene repertoire for sterol biosynthesis in unicellular holozoans EBP SQLE DHCR24 SMO DHCR7 HSD17B7 TM7SF2 PMC8439554__F1 Mechanisms Contributing to MAC Pathogenesis ALPL DDR1 MGP GLA ABCC6 RUNX2 ENPP1 PMC6525811__F1 miR-7 playing a neuroprotective role in PD NLRP3 KEAP1 RELA PMC4382287__F2 Pathway as a Pharmacological Target for Herbal Medicines: An Investigation from Reduning Injection MAPK1 MAPK14 NOS2 MAPK11 MAPK13 IKBKB RELA MAPK9 MAPK12 PTGS2 MAPK8 TNF PMC4577305__F2 The Secretory Pathway Kinases FAM20C DMP1 FURIN FGF23 PMC6702336__F3 Summary of the role of the ERK1/2signaling pathway in CIRI BAX EGFR MFN2 PMC11923548__F10 Paeonia suffruticosa Andrews root extract ameliorates photoaging via regulating IRS1/PI3K/FOXO pathway KEAP1 ATM MTOR GADD45A IRS1 PMC4267483__F1 Noonan syndrome HRAS CBL RAF1 SOS1 SHOC2 BRAF PTPN11 GRB2 KRAS PMC9045977__F3 Mitochondrial Dysfunction Pathway Alterations Offer Potential Biomarkers and Therapeutic Targets for Ovarian Cancer LAT FES CYC1 PMC7268158__F2 The JAK/STAT system in graft-versus-host disease CXCL11 IFNG CXCR3 HMGB1 CSF2RA FAS FOXD3 CSF2RB NLRP3 PMC7268158__F1 JAK/STAT System IFNG MPL IL13 IL4 EPO STAT4 TYK2 PMC5771830__F5 Cancer cell metabolic changes linked to hyper-O-GlcNAcylation OGA OGT EGF HIF1A MYC KRAS PMC5036249__F7 Proposed mechanistic scheme of CA4 suppressing the Wnt signalling pathway in colorectal cancer CA4 WT1 WTAP CTNNB1 PMC8301472__F2 Molecular Mechanisms of Resistance to Immune Checkpoint Inhibitors in Melanoma Treatment: An Update CD80 CCL22 CCL28 COX2 CCR4 ARG1 MMP9 CCR10 CTNNB1 PMC4074217__F5 Comparison of apoptotic pathways and NLRP3 inflammasome activation MAVS NLRP3 MFN2 PMC6668984__F6 KEGG pathway enrichment analysis in signalling pathways STAT1 RAF1 ARRB2 NFKB1 RAE1 SRC PMC3458933__F7 Schematic overview of the results from the present study indicating WNT-5A secretion from astrocytes and the WNT-5A-induced signaling pathway towards ERK1/2 regulating distinct aspects of the proinflammatory transformation of microglia MMP9 PMC3123876__F6 Profiling experiments and pathway analysis C2 EHF PRSS2 PRSS1 ST18 TUBB EDAR MED1 MED13 PMC6225658__F2 Representative image of the anti-angiogenic potential of autophagy PEG3 PMC3507178__F3 Flow chart depicting the metabolic pathway of fatty acids in the liver of GH transgenic Amago based on 3′-tag digital gene expression profiling and comparison of serum triacylglycerol and glucose, and 3-hydroxybutyric acid LPL TG MID1IP1 ELOVL2 ACSL1 FAS HEL-S-5 ELOVL5 ELOVL6 PMC2759974__F1 MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer JUN DMP1 DHFR APC GSK3B WNT1 MDM2 CCND1 FOS CDK4 CTNNB1 PMC8539290__F2 Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids DDT BAX CASP9 HEL-S-8a MMP12 VCAM1 TRAF2 PMC9655983__F9 Src Family Kinases Facilitate the Crosstalk between CGRP and Cytokines in Sensitizing Trigeminal Ganglion via Transmitting CGRP Receptor/PKA Pathway TG CXCL1 CCL2 IL1B PMC8983667__F1 Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway GNAS REC8 GNRHR ADCY1 PMC7578381__F6 Functionally grouped network visualization for epigenetically upregulated and downregulated genes BIN2 FERMT3 HK3 KRT16 WIPF1 PTPRC LILRA2 ALDH3A1 LAG3 TNFAIP6 OSCAR KRT3 TREML2 PKP3 KRT40 KRT78 KRT32 GNS KRT76 LILRB2 BTLA CD300LF P2RX1 PPL KRT13 PMC8448728__F5 PIGG defines the Emm blood group system PIGP PIGC GPAA1 PIGH DPM2 PIGV PIGU PGAP1 PIGT PIGO PIGF PIGN PIGW PIGA PIGY PIGX PIGB PIGL HEL-S-5 PIGK PIGS PIGM PMC5507646__F1 BRAF mutations in the context of mitogen‐activated protein kinase (MAPK) molecular alterations ROS1 EGFR BRAF KRAS PMC3388569__F3 Common biological pathways activated in OVCA cells in response to chemotherapeutic agents HRAS BAD MAK APC SHE OPTN RET SET PMC4987202__F1 Axotomy activates the Wallerian degeneration pathway for the selective elimination and degeneration of severed axons NGF SARM1 NMNAT2 PMC3388569__F2 Shared biological pathway activation between chemotherapeutic agent treatments BAD APC 5HT1A MIF HTR2A PMC5675569__F3 Network of selected factors influencing myofibroblast survival/resistance to apoptosis EGF TGFB1 THY1 SPARC CASP3 PTEN CTNNB1 PMC6414158__F4 ceRNA regulatory network associated with the MAPK signaling pathway ATF2 PPM1B PMC5891635__F1 Two working models explaining Sgg association with colorectal cancer (CRC) SLC10A2 COX2 CTNNB1 PMC3822531__F2 Regulation of Wnt/-catenin signalling pathway.(A) Wnt forms a ternary complex with Fz and Lrp5/6, which promotes stabilization of Beta-catenin, thereby activating the pathway APC LRP5 LRP6 CTNNB1 PMC6612304__F1 An integrative model of the roles of mitochondrial metabolism in liver cancer stem cells CD44 HK2 HEL-S-162eP SOX2 BCL2 MYC PMC6446925__F1 AMPK Signaling Pathway TRO EEF2K EEF2 PMC3756375__F2 Nerve growth factor (NGF) signaling in breast cancer cells NGF BEX2 TRADD PMC9449101__F1 Key Metabolic Regulator of Bone and Cartilage Health CAD pcap PMC8335742__F9 Dimethyl itaconate inhibits LPS-induced microglia inflammation and inflammasome-mediated pyroptosis via inducing autophagy and regulating the Nrf-2/HO-1 signaling pathway GSDMD NLRP3 KEAP1 IL18 PMC6214712__F1 Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Cell Phenotypes KLF4 FOXA1 BRD4 GATA1 SOX2 RUNX2 RBPJ HSF2 CHD4 CTCF RUNX1 UTF1 FOXL1 GATA4 BRD2 PMC1754372__F2 Th1- and Th2-like lymphocytes, and the key regulatory cytokines and their interactions in SS IFNG IL10 APC IL6 IL1B PMC7853129__F6 CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFB TEC FOXC2 SMAD2 SRC PMC3199809__F1 The TGFB signaling pathway SMAD2 SMAD4 PMC8200556__F2 Genetic Determinants Highlight the Existence of Shared Etiopathogenetic Mechanisms Characterizing Age-Related Macular Degeneration and Neurodegenerative Disorders ARMS2 APOE MIF IL23R PMC3650458__F1 Simplified overview of classical bile acid synthesis pathway in mice AKR1D1 CYP8B1 CYP7A1 PMC11763988__F4 Antioxidant role of butyrate in promoting animal health BAX KEAP1 NQO1 PMC5584166__F4 Signaling pathways that can cross talk with TNT formation FOXO3A TFEB PMC8139556__F1 PI3K Inhibition in the Treatment of Breast Cancer, Alone or Combined With Immune Checkpoint Inhibitors INPP4B PTEN MTOR PMC11560440__F4 Pathogenesis of SjD TLR8 PMC6605697__F7 Possible antifibrotic mechanism of exogenous hydrogen sulfide in diabetic cardiomyocytes GSK3B CTNNB1 PMC3777178__F3 Multifunctional phosphorylated PDZ proteins integrate signaling pathways to control hyperplasia, neoplasia, and cell metastasis CDC2 CDK2 PTEN SCRIB PMC4508759__F1 Neurons versus herpes simplex virus: the innate immune interactions that contribute to a host–pathogen standoff TF CGAS MAVS TLR9 RNASEL IRF3 IRF7 RAC1 MYD88 STAT1 TLR3 MX1 TLR7 PMC4831356__F1 Schematic model illustrating O‐GlcNAc pathway and influence of glucose and O‐GlcNAcylation on chondrogenic differentiation OGA OGT SMAD2 SMAD4 PMC3576882__F4 NFKB: Roles and Regulation In Different CD4+ T cell subsets CD80 BCL10 MTOR PMC11837354__F1 Main metabolic pathway of catecholamine biosynthesis TH DBH DDC PMC11940455__F5 Signaling pathway activated by EGFR and TRKB receptors resulting in cell proliferation EGF EGFR GRB2 MTOR BDNF KRAS PMC8388553__F9 Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3B signaling pathway BAX ARRB2 GSK3B BCL2 PMC2668371__F9 The proposed model RHEB MTOR EIF4E PMC6914362__F10 Metabolic control of BRISC-SHMT2 assembly regulates immune signaling IFNAR2 IFNAR1 HEL-S-51e PMC3625980__F7 FBXW7A attenuates inflammatory signalling by downregulating C/EBPD and its target gene Tlr4 TLR4 MTOR NOTCH1 PMC11884102__F1 Signaling pathways in fibrotic processes involving macrophages SMAD2 SMAD4 MTOR TNF MMP11 PMC7830660__F1 Immune evasion by NSVs STAT1 TLR3 STAT2 MVP TLR8 IRF3 IRF7 TLR7 IL6 JAK1 MYD88 PMC4564644__F1 Diagram showing the possible mechanism of serotonin mediated signaling pathway activated by BME during learning AGO2 SYP TPH2 HEL-S-11 BDNF CREB1 PMC5107592__F1 Toll-like receptor signalling pathway TBK1 TLR3 TIRAP TLR4 TLR9 CD14 IRAK1 IRF3 IRF7 TRAF6 IRAK4 MYD88 PMC12185857__F3 Fructose promotes systemic chronic inflammation NLRP3 TXNIP TLR4 TNF PMC7973006__F1 In stationary state, the aryl hydrocarbon receptor (AHR) is part of a complex composed by the 90kDa heat shock protein (HSP90), the co-chaperone p23 (p23) and the hepatitis B virus X-associated protein (XAP2/AIP/ARA9) AHR AHRR TIPARP CYP1B1 PMC11932893__F3 Regulatory mechanisms of AMPK in MASH-associated inflammatory response ULK1 SMAD2 HDAC5 MTOR FNIP1 MFF SIRT1 IL1B PMC11932893__F2 Molecular mechanisms of AMPK-regulated lipid metabolism FAS TXNIP ULK1 FASN TFEB PMC5537006__F1 Top Ingenuity Pathway Analysis networks associated with genes whose expression is altered by high levels of miRNA expression associated with both TP53 and CpG island methylator phenotypehigh and/or microsatellite instability WDR12 PHF20 DTX3 BCAS3 DCTPP1 MYC PPP3CC ELMO2 UBA2 SRCAP CDR2 TM2D3 GNL3L NCS1 ZNF346 GGH AQP11 ATAD2 RBMS1 SLC19A2 NXN TNFSF13 GCLM CLIP3 TMEM14C UBE2V1 RPS20 ADK ZNF48 ELMOD1 NSMCE2 NSMCE1 DLEU7 TM2D2 RNF112 PPP1R14C PDCD11 PARP4 UTP4 ULBP3 ZFYVE28 MLKL DACT3 AMOTL1 CDC42EP1 FGD4 NSMAF TNFRSF17 RUSC2 THAP1 BEX2 CLPB GLA MSRB1 NLRP2 SEPHS2 HUNK CLEC3B TRPM6 CARD6 NR3C1 NOSIP MTDH SULT2B1 STX2 DAPK2 PMC12234872__F2 Cellular senescence and other age-related mechanisms in the pathogenesis of OP DNMT3B CXCL12 TGFB1 OSM MAP1LC3A CCR5 LEPR CTLA4 SPP1 TPM1 CD24 FOXO3A TFEB DPP4 GCA METTL3 SOX5 PMC3236328__F2 The differentiation hierarchy within the mammary epithelium and potential relationships with breast cancer subtypes CD24 RELB KIT ERBB2 PMC9483046__F1 Research Progress on Exosomes in Osteonecrosis of the Femoral Head MSC RUNX2 CD34 PMC3236328__F1 Main NFKB-activating pathways CD40 TAB3 RELB TRAF3 TNF TRAF2 PMC7681022__F1 Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism TYMS PMC7526609__F2 IL-2 mediated JAK-STAT signaling pathway in COVID-19 associated male infertility.This figure shows IL-4 JAK-STAT Pathway and their effect on male infertility, during the event of infection by SARS-CoV-2 STAT3 CD36 JAK1 MAOA PMC8615515__F6 Vitamin-Containing Antioxidant Formulation Reduces Carcinogen-Induced DNA Damage through ATR/Chk1 Signaling in Bronchial Epithelial Cells In Vitro ATR AOX1 BRCA1 PMC9034118__F1 Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma SUFU PTCH1 SHH SMO GLI3 PMC3429940__F1 Optimizing treatments for lymphangioleiomyomatosis RHEB TSC2 TSC1 CDK2 HIF1A RHO PMC6069177__F7 Phosphorylation of the HPV E6 PBM links cellular stress response signaling to E6 inhibition of p53 transcriptional activity ATR ATM MDM2 PMC8392322__F3 Ups and Downs of STAT Inhibition in Acute Myeloid Leukemia FLT3 STAT3 JAK1 PMC8392322__F1 Ups and Downs of STAT Inhibition in Acute Myeloid Leukemia STAT3 STAT1 STAT2 JAK3 STAT4 JAK1 TYK2 PMC4320493__F7 Proposed model of the distinct features of Hh signal transduction in insect, fish and mammal SUFU PTCH1 SMO PMC2807379__F8 Nephronophthisis: Disease Mechanisms of a Ciliopathy SUFU PTCH1 SMO GLI3 PMC2807379__F6 Nephronophthisis: Disease Mechanisms of a Ciliopathy REST APC GSK3B LRP5 LRP6 RHO CTNNB1 PMC2807379__F4 Nephronophthisis: Disease Mechanisms of a Ciliopathy SHH NPHP1 NPHP3 PACS1 IFT80 PMC3554339__F1 Actions of Nec-1 and its derivatives in a mouse system IFNG RIPK3 TRADD TRAF5 RIPK1 TNF CYLD TRAF2 FADD PMC6096743__F5 Relationship between individual genes composing the ‘blood vessel development’ ontology group CAV3 VEGFC CXCL12 THBS1 THY1 MEOX2 ECSCR TGFBR3 PRRX1 CD44 S1PR1 NR2F2 SCG2 FLT4 TNFAIP2 GJC1 EGFL7 LAMA4 ELK3 PLXDC1 ROBO4 EMCN PMC6401500__F2 Activation of NFKB in ITME CD40 TRADD RELB ATM TRAF3 TRAF6 SSB TRAF2 PMC12226124__F4 Association of the inflammasome cascade with AD immunopathology NLRP1 GSDMD NLRP3 IL18 AIM2 PMC4955784__F1 Molecular and Genetic Inflammation Networks in Major Human Diseases CDC42 STAT3 EGFR GSK3B PIK3R1 PTEN IGF1R MTOR CTNNB1 EIF2S1 PRKCE PDPK1 ACTR8 PRKCA MUC1 RPS6 EIF2B5 PNN AXL TIMELESS EIF4EBP1 PER1 MAPKAPK2 CRY1 EIF2S2 RPS27A PTPN11 EIF2S3 RPS18 SET RHEB TSC2 TSC1 RPS28 CHEK1 HSPA4 PRKAB1 INPPL1 PMC6548290__F1 MAPK and MST2/Hippo signaling, energy and glucose metabolism ARAF KSR2 ENO1 PMC10925886__F4 Lymphocyte behaviors and functions by the circadian clock S1PR1 IL10 BCR CCL21 CMIP CCR7 NFIL3 PMC10925886__F3 Myeloid cell behaviors and functions by the circadian clock CXCL12 CCL21 CXCL2 IL8RB CXCR4 CD99 PMC3552779__F1 Aerobic glycolysis, the citric acid cycle, and key glycolytic shunts HEL-S-133P PHGDH HEL-S-68p F2 HK2 HEL-S-162eP ENO1 PFKM PMC2704241__F5 Hepatic methionine metabolism and GSH synthesis HEL-S-61p PMC6317189__F4 Targets molecules of bta-mir-182 involved in the apoptosis signaling pathway HEL-S-31 CDC2 CASP9 CASP2 PRKCE ROCK1 CYCS BCL2 BCL2L11 CAPN5 PMC5713451__F1 Physiologic and oncogenic Hedgehog signaling SUFU PTCH1 SMO PMC2677399__F2 Nuclear Factor KB, Airway Epithelium, and Asthma LTB IL16 RELA RELB TNF PMC7557389__F9 Proposed pathway showing the effects of nanopriming with MWCNT–COOH on the membrane lipid metabolism of peatland boreal forest species in response to possible alleviation of seed dormancy and improved vigor LPA PGP PSD PC PSD2 PMC8229730__F2 New Insights of SF1 Neurons in Hypothalamic Regulation of Obesity and Diabetes STAT3 SF1 FOXO1 LEPR SOCS3 PMC6966427__F1 B-cell receptor pathway SYK BTK BCR PLCG2 TLR9 IRAK1 BLNK IRAK2 MTOR TRAF6 MYD88 PMC6631594__F2 In the absence of Hh signal, Patched1 (Ptch1) inhibits the Hh pathway through the modulation of the Smoothened (Smo) SUFU SHH SMO PMC3230808__F7 Regulation of CYP1A1 by capsaicin in Hepa-1c1c7 cells CPZ EBP TRPV1 AHR CYP1A1 PMC9259834__F1 Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies GDF8 FST SMAD2 SMAD4 MTOR DCN PMC4632748__F3 Tamoxifen pathway and possible mechanisms of endocrine resistance in breast cancer cells PELP1 EGFR SRC PMC6334777__F4 Activating MAPK Pathway Mutations in LCH ERBB3 ARAF BCL2L1 CCR7 MAP2K1 PMC4632748__F7 Possible involvement of candidate microRNAs in tamoxifen resistance pathways, based on the present literature search and IPA analysis FOXA1 CYP24A1 TIMP3 HOXB1 EGFR KDM3A PAG1 HOXA1 PELP1 CDK6 IGF1 BCL2 SRC PMC3315189__F1 S-ADENOSYLMETHIONINE TREATMENT OF ALCOHOLIC LIVER DISEASE: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL HEL-S-182mP MAT1A PMC3397897__F8 Schematic presentation of signaling pathways and their downstream targets that are affected by a feedback loop between hBVR and PKCD PC TNF FOS PMC5601349__F1 Alternative pathways of gluconate-6P formation by dissimilation of glucose in Burkholderia FRK HEL-S-32 TNLG7C PMC4632748__F1 Simplified possible molecular signaling pathways (1 to 6) of estrogen (E) and estrogen receptors (ER) TF PELP1 EGFR SRC PMC3039708__F3 T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics APC FOXP3 PMC3039708__F2 T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics STAT1 PTEN MTOR TRAF6 MYD88 PMC5360632__F1 Combined Role of Vitamin D status and CYP24A1 in the Transition to Systemic Lupus Erythematosus NR1i1 CYP27B1 CYP24A1 RXRA GC RXRB PMC8217840__F1 LRRK2-NFATc2 Pathway Associated with Neuroinflammation May Be a Potential Therapeutic Target for Parkinson’s Disease LRRK2 NFATC2 PMC4872230__F5 Identification and Characterization of miRNAs in Chondrus crispus by High-Throughput Sequencing and Bioinformatics Analysis LPL UBC UCP1 HEL-S-28 PMC7072741__F10 Postulated differences in the CXCR4-LASP1-AKT1 signaling between breast cancer and CML CXCL12 CRKL MTOR CXCR4 PMC5796629__F2 ROS generation metabolomics, transcriptomics, and metabotranscriptomics PDE2A EGFR EPO UCP1 NR1C2 HTR2A PSEN1 MPO ALB RB1 PRKCE TLR4 IL18 CALB1 SRC P2RX7 VIP NOS2 PYY APOE ACOD1 SNCA IL4 CXCL2 ARHA FGF2 IGF1 IKBKB BCL2 CYP3A4 PMC7425302__F2 Interferon G signaling pathway CXCL9 IFNG STAT1 IFNGR2 IFNGR1 BRD7 STAT2 PBRM1 IRF1 ARID2 JAK1 CXCL10 PMC7425302__F1 Cancer resistance to immunotherapy IFNG IFNGR2 CD80 IFNGR1 APC B2M PMC8353790__F1 Adiponectin in psoriasis and its comorbidities: a review IL6 IL23R PMC8786287__F3 Metabolic adaptation of super-complexes SCAF1 OPA1 ATF4 PMC12245688__F3 Antitumor effects of HDACi ACTA2 COL1A1 PINK1 PSMB8 LIF NFE2L2 MIF PMC3571454__F10 Models for intrinsic signaling by BST2 and for BST2 as a virus sensor MAP3K7IP1 TRAF2 MYD88 PMC12245688__F2 Action of HDACi on immune cells COL1A1 UBE2C ARG1 TCF4 VEGFA BCL6 LEF1 PMC6719619__F1 T-cell development ZBTB16 TBX21 GATA3 RUNX3 PMC3877719__F1 Analysis with NIH DAVID, Princeton GO term finder and Ingenuity Pathway Analysis yield similar gene enrichments, biological processes and pathways.The high confidence hit list was also analyzed by IPA for biological pathway enrichment CA4 ARPC4 PLCB4 ITGB4 PADI4 RRM2 EIF6 CAPNS1 TRIM28 TRPA1 DCLK1 PLCG2 AVPR1B PPP1R9B UNG PMC6521789__F6 Mammalian PUFA synthesis pathway showing the n-3 PUFA pathway and the n-6 PUFA pathway, including the enzymes responsible for the elongation and desaturation steps ELOA FADS2 ACD FADS1 PMC8071059__F2 Priming effects of stress on NLRP3 inflammasome in microglia HMGB1 NLRP3 IL16 IL18 CCL4 CCL2 TNF IL1B PMC4681988__F14 Aspirin blocks signaling pathway involved in platelet activation as laid out by our algorithm MAPK1 GNAI1 GNGT1 RAF1 INA F2RL3 MAP2 MAPK3 GNB1 HRAS F2R F2 PLCB1 PTGS1 RAE1 PMC4042208__F1 Stress signaling pathways activated by electrophiles KEAP1 ATF4 EIF2A PMC9298969__F1 Glucagon-Like Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating Remedies FOXO1 GSK3B ARHA MTOR PMC2966904__F7 Proposed scheme of the signaling pathway by TfR2 and HFE TF HAMP HFE FURIN HFE2 PMC11675435__F3 Nrf2 signaling pathway in RCC CDKN2A KEAP1 HIF1A SETD2 PRCC VHL PMC11675435__F2 KEAP1–Nrf2-ARE pathway in constitutive condition and under oxidative stimuli RBX1 KEAP1 PMC7246552__F1 Summary of methyl and methionine metabolism GAA HEL-S-20 PEMT PC HEL-S-61p PMC4135953__F10 The gene-to-gene networks of TLR3, TLR4, and poly(I·C) in mice immunized with UV-V after SARS-CoV challenge CD40 CXCL9 TREM1 RGS16 NR4A3 PHLDA1 GBP4 IL1R2 STAT1 EREG NLRP3 PPP1R15A TLR4 GDF15 RGS1 GBP2 THBS1 ADM PLAUR APC CD14 IRF1 CXCL2 DUOX2 NFKBID HEL110 PMC6580702__F8 Negative regulators of NRF2 are found in autophagy ATG101 ATG10 RAB1A ATG3 TMEM41B ATG12 KEAP1 ATG9A ULK1 RB1CC1 ATG5 ULK2 PMC2869521__F4 Solid tumors activate the NFKB pathway to maintain cell survival TBK1 RALB MTOR CYLD PMC2869521__F3 Constitutive NFKB pathway activation in multiple myeloma CD40 CSA2 LTBR RELB TRAF3 CYLD TRAF2 PMC2869521__F1 Role of BCR signaling to NFKB in ABC DLBCL CD79B SYK CD79A BTK BCR CARD11 BLNK MTOR TRAF6 PMC1850774__F5 Convergence of signaling pathways BAD FYN HEL-S-28 PTEN GRB2 CTNNB1 PMC2938013__F9 Dixdc1 is a critical regulator of DISC1 and embryonic cortical development DIXDC1 CDK5 GSK3B DISC1 NDEL1 CTNNB1 PMC2745765__F3 Linking the MGI and MouseCyc databases GAL KL PMC6704701__F6 Illustration of the mechanism of SOX2 promotion of breast cancer cell migration SOX2 HIF1A NEDD9 RAC1 PMC12172487__F1 Metabolic pathway of Sia and EV-D usage SIAT4C GAL GNE ST6GAL2 ST3GAL6 ST6GAL1 ST3GAL5 CMAS ST3GAL3 NANS SLC35A1 ST3GAL1 PMC8905560__F4 Prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis CD40 CD80 TIRAP CD69 TAB3 MAL CD14 IRAK1 IRAK2 CS TRAF6 IRAK4 MYD88 CD83 MAP3K7IP1 TLR4 PMC3699383__F1 Apoptosis pathways BAX BAD FADD PMC8205579__F7 Baicalin Magnesium Salt Attenuates Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting of TLR4/NFKB Signaling Pathway IL16 TLR4 IRAK1 TRAF6 TNF MYD88 PMC8385203__F10 Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2Alpha-Stat3 pathway in diabetic cardiomyopathy STAT3 OPA1 PMC7725927__F1 mTORC1 signaling pathway RHEB TSC2 TSC1 GRB2 ELF3 PMC6756496__F3 Proposed signaling pathway in type II receptor cells TG TRPM5 CALHM1 PMC8741844__F1 CircCCNB1 silencing acting as a miR-106b-5p sponge inhibited GPM6A expression to promote HCC progression by enhancing DYNC1I1 expression and activating the AKT/ERK signaling pathway MCC ADA PMC7156451__F9 Glycogen metabolism regulates macrophage-mediated acute inflammatory responses STAT1 PYGL RARB GYS1 PMC2570299__F3 Role of GalGlyNAcPVv in V GAL ABO NAGK PMC10468807__F1 lncRNAs are involved in tumor cell lipid metabolism by targeting different signaling pathways TG ACSL1 RXRA MTOR PMC4452864__F2 TGFB and ROS interplay FURIN NOX4 PMC4835201__F10 A hypothetical diagram illustrates potential mechanisms in silicosis TICAM1 TLR4 MTOR MYD88 PMC6256271__F5 Targets of BA, JA, and BJ in the CD27 signaling pathway in lymphocytes CD27 APAF1 PMC5876306__F3 MYC and HIF-1 regulate glucose metabolism HEL-S-133P HEL-S-162eP MYC PMC7064563__F6 Metabolic pathways associated with EPS production in Phaeodactylum tricornutum MPG FRK NDP PMC9327618__F3 Pre-clinical Studies Identifying Molecular Pathways of Neuroinflammation in Parkinson's Disease: A Systematic Review RELB IL6 IL1B PMC10377333__F1 Indoleamine 2,3-Dioxygenase (IDO) Activity: A Perspective Biomarker for Laboratory Determination in Tumor Immunotherapy HEL-S-90n KYNU KMO AHR IDO2 PMC12022316__F8 Mechanistic scheme of this study IGF2BP3 DVL2 METTL3 PMC4528072__F2 Model for the mechanisms leading from impaired regulation of the alternative pathway to hemolytic uremic syndrome (HUS) VWF FH HEL-S-62p THBD PMC3310792__F8 Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells TG FAS PC PMC2677763__F7A Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways KLHL1 KEAP1 GPX4 MGST1 ATF2 GPX3 GPX1 HEL-S-2a MAF ATF1 ATF4 HEL-S-26 EPHX2 HEL-S-44 UGT1A1 JUN BATF ATF5 FOS UGT8 ATF3 GPX2 EPHX1 HEL-S-75p GPX7 HEL-S-64p HEL-75 PMC6520346__F6 Metabolomic analysis of in vitro effects of OPC-163493 in HepG2 cells ddo PMC8191541__F2 Viperin Reveals Its True Function STAT1 MAVS STAT2 IRF9 IRAK1 IRF1 IRF3 IRF7 CMPK2 TRAF6 PMC4292778__F4 Gene network analysis of top HHT associated genes CASP2 SPRY4 STX6 SIRT4 CASP12 BANK1 AKR1B1 PRDX3 PAWR TRAF5 SCD5 NRF1 AID UNK FADD PMC8560908__F1 The interplay between NFKB signaling and ARTD family members PARP10 TBK1 PARP12 MAVS PARP14 RELB PARP1 PMC9083113__F8 Age Related Changes in Muscle Mass and Force Generation in the Triple Transgenic (3xTgAD) Mouse Model of Alzheimer’s Disease SMAD2 APP PMC11704404__F2 Autophagy initiation regulated by AMPK and mTORC1 ATG101 RHEB MLST8 TSC2 TSC1 ULK1 ATG14 MTOR DEPTOR ULK2 PMC11704404__F1 Schematic diagram illustrating the role of hepatic AMPK in regulating lipogenesis and lipolysis FASN ACCS MTOR SIRT1 PMC8138054__F3 Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances KLF4 CDC42 CDH2 EPHB4 STAT3 BAX SP1 AGO2 EGFR GSK3B MTOR CTNNB1 CD44 RGS4 SHH ABCB1 PMC11003747__SF3_2 I6pDel p-proteome network analysis PRRC2C NASP EIF4B HDGFL3 SMARCC2 EIF4EBP1 LARP4 EIF3A HMGN3 NCBP1 PMC11003747__SF3_1 I-ASD p-proteome network analysis RBMX SMARCC1 RPS6 BRD4 THRAP3 EIF3A YBX1 PRPF40A MLST8 RBM25 CDK12 PALLD ZC3H18 SOX5 PMC5484669__F3 Signaling pathways that are key regulators of pluripotency in mESCs LIF SOX2 TBX3 PMC7098997__F4 Changes in proteins involved in the oxidative stress metabolic pathway PEX14 MPV17 PEX19 PTS PEX6 PEX5 PXMP4 PEX2 PEX3 PMC7098997__F3 Changes in proteins involved in carbon metabolism and oxidative stress metabolic pathway MAL DLD PMC3829115__F1 Schematic overview of TF signaling complexes TF TFPI APC PMC8560908__F5 The interplay between AKT signaling and ARTD family members TSC1 PHLPP1 FOXO1 GSK3B PARP3 PARP2 SIRT1 PARP1 PMC8560908__F4 The interplay between MAPK signaling and ARTD family members TNKS2 MOS PARP14 ATF4 PARP1 PMC8560908__F2 The interplay between JAK/STAT signaling and ARTD family members HDAC3 STAT1 PARP11 PARP14 DTX3L HDAC2 PARP1 CP PMC8637879__F2 Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy GSDMD NLRP3 TXNIP DFNA5 PMC4365493__F8 The signaling pathway through which MIF increases vascular permeability CD44 CD74 MIF IL8RB MTOR CXCR4 ATG5 PMC8294384__F6 Hepatic lipid metabolomics in response to heat stress in local broiler chickens breed (Huaixiang chickens) CYP1A2 CYP2E1 CYP3A4 PMC2974170__F1 Diagram of TLR signaling pathways TBK1 TIRAP TLR9 IRAK1 IRF3 IRF7 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TLR8 TLR7 PMC2398704__F3 High and low pollen-hoarding strain bees IGF1 PIN4 PIN1 PMC7535936__F5 Schematic outline of the Nodal signaling pathway in vertebrates FOXH1 GDF3 SMAD2 SMAD4 NODAL GDF1 PMC3364883__F2 Protein processing in endoplasmic reticulum is altered in Manf mutants SVIP SP1 SEL1L ATF4 PMC10650070__F2 NFKB, MAPK and Oct-1 pathways for expression of Beta-defensins LTA MYD88 PMC12218123__F1 Folate metabolic pathway; connection between the folate cycle and methionine cycle CTH HEL-S-61p PMC3364883__F5 Gene expression alterations in Manf mutants with a linkage to Parkinson's disease CASP9 SNCA PMC3364883__F4 Changes in gene expression related to endocytosis in Manf mutants LDLR DEPTOR OTP VPS36 PMC8126649__F1 Biological Characteristics of Umbilical Cord Mesenchymal Stem Cells and Its Therapeutic Potential for Hematological Disorders FAS CDK6 CDK4 PMC4120774__F6 ATTENUATION OF MULTI-TARGETED PROLIFERATION-LINKED SIGNALING BY 3,3′-DIINDOLYLMETHANE (DIM): FROM BENCH TO CLINIC PDK2 MTOR PMC4263370__F6 SteatoNet: The First Integrated Human Metabolic Model with Multi-layered Regulation to Investigate Liver-Associated Pathologies LPA NR1C1 ADIPOR1 ADIPOR2 TLR4 PMC4154379__F9 Tumor Necrosis FactorA Augments Matrix Metalloproteinase-9 Production in Skeletal Muscle Cells through the Activation of Transforming Growth Factor-Beta-activated Kinase 1 (TAK1)-dependent Signaling Pathway TRADD TNF TRAF2 FADD PMC4120774__F9 ATTENUATION OF MULTI-TARGETED PROLIFERATION-LINKED SIGNALING BY 3,3′-DIINDOLYLMETHANE (DIM): FROM BENCH TO CLINIC APC MYC CCND1 CTNNB1 PMC3376488__F6 TRIF signal pathway JUN TLR3 TAB3 IRF3 ATF2 TRAF6 PELI1 FADD PMC5846637__F7 PD0332991-regulated gastric cancer cell signaling networks BAX NGF DDR1 APC PTEN CCND1 CP PMC3376488__F5 MyD88 signal pathway MAP3K7IP1 TAB3 MAL IRF3 ATF2 IRF4 TRAF6 TNF IRAK4 MYD88 PMC3376488__F2 T-cell development and differentiation STAT3 SOS1 IL16 IL6 PMC7557985__F11 Differential mechanisms of CK2.3 in osteoblastogenesis and osteoclastogenesis DCSTAMP RUNX2 PMC3316585__F1 Formal Modeling and Analysis of the MAL-Associated Biological Regulatory Network: Insight into Cerebral Malaria BTK TLR4 MAL PMC7780025__F1 Mammalian Hippo‐YAP signaling network LATS1 LATS2 TEAD2 TEAD3 AMOT SCRIB NF2 SRC YAP1 TEAD4 PMC8641375__F7 Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice RAB5A TLR4 IL1B MYD88 PMC6196654__F1 Network of the two sets of top genes with P-value < 0.01 in the case–control and family-based analyses focusing on rare, deleterious variants GDF8 THSD4 INHBC CHRM3 GANAB IFT140 GNG3 VNN2 IFT43 ENG SEC16A INHA WDR35 GRB2 PMC11872695__F1 Illustrates the interplay between gut microbiota, ImP production, and cardiometabolic diseases EGFR FGF21 CX3CL1 PMC6260573__F7 Flavonoids downregulate mdr1 expression through wnt/Beta-catenin signaling pathway APC LRP6 FZD1 CTNNB1 PMC10499775__F1 Illustration of the Fas-FasL pathway FAS CASP8 MTOR CASP10 FADD PMC90529__F7 Genomic Profiling of the Response of Candida albicans to Itraconazole Treatment Using a DNA Microarray COQ7 IPP ID2 PMC7769200__F8 Schematic model illustrating the biological roles of the hsa_circ_0000714/miR-370-3p/RAB17 regulatory axis in A2780/PTX paclitaxel-resistant ovarian cancer cell RAB17 CDK6 CDK4 PMC11326265__F7 The effect of miR-1 loss on glycolytic and pentose phosphate enzymes and intermediates SLC16A3 PDK4 PTBP1 H6PD HEL-S-162eP ENO1 HEL-S-87p PMC3240145__F2 Intrinsic and extrinsic pathways of apoptosis BAX DIABLO FADD PMC4674284__F1 A working model of how the NLRC5 ubiquitination and deubiquitination feedforward loop shapes IKK/NFKB activity TLR4 TRAF6 TRAF2 PMC3563666__F4 Altered Cytokine Gene Expression in Peripheral Blood Monocytes across the Menstrual Cycle in Primary Dysmenorrhea: A Case-Control Study TF BMPR2 PPARG CASP9 SMAD1 CASP8 SMAD4 PTGS2 TNF GDF5 BMP6 HMOX1 NR1C1 BMP4 CASP3 MMP2 BCL2 EP300 HEL-S-44 PMC4559943__F1 Schematic diagram of the assembled modules to convert galactose to n-butanol HBD GALP PMC3689941__F9 STAT3 pathway switching is induced by EMT during breast cancer progression STAT3 EGFR SRC PMC8461988__F1 Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis LTA TLR4 EGFR CD14 PTGS2 KRAS PMC8646045__F7 Activation of A7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson’s Disease Rats COX2 CD163 CD68 IL1B PMC3775430__F5 Model for possible sequence of genomic events in PCA progression TMPRSS2 PTEN ERG PMC5543755__F5 Protein complex analysis DLG2 CUX2 HGS FRS2 KCNA4 DLG4 CRIPT ARC FOS EPN2 PMC5543755__F4 Merged mouse and rat network (mapped to human proteins) and overlapping Reactome pathways HABP4 RRAGD NUBPL NTRK2 MTOR CS ARC NUBP2 EPN3 STAU1 CCKAR DRD2 C2 PREX2 NARF PMC7070911__F1 Metabolic pathway and mechanism of action of Clopidogrel CYP2B6 CYP2C19 PMC5999788__F2 Integration of actions of PKD1 and PKD3 in cardiac energy metabolism—a hypothetical scheme PKD1 CD36 HDAC5 HDAC7 SRC PMC9337250__F4 Bile acids and sphingolipids in non-alcoholic fatty liver disease S1PR1 S1PR2 PTEN RHO S1PR4 PMC9314780__F3 Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations VIT IGF1 KL IGF1R CTNNB1 FGF23 PMC9673322__F7 Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis CD40 TRAF6 IL1B PMC9337250__F2 Bile acids and sphingolipids in non-alcoholic fatty liver disease CYP8B1 BAAT CYP7A1 GCA CYP7B1 CYP27A1 PMC7699465__F1 Nelfinavir inhibits the Nrf1-dependent synthesis of proteasome subunits and inhibits the proteasome, leading to accumulation of misfolded proteins that activate IRE1A and PERK arms of the UPR STAT3 PCNA SMAD2 HIF1A MTOR CDK2 ATF4 MDM2 EIF2A NRF1 SESN2 TRIB3 RET PMC3775430__F1 PI3K/PTEN/Akt pathway PTEN MTOR PMC7222024__F4 Sugar and lipid metabolic pathways affected by oxygen availability SCARB1 CD36 LDLR PMC5773247__F1 Wnt Signaling in Cardiovascular Disease: Opportunities and Challenges CDC42 JUN USF1 LRP5 LRP6 IL4 RYK MTOR ARHA RUNX2 RAC1 CTNNB1 KLF5 MSX2 PMC9688074__F7 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases FUT2 TLR4 IL1B CTNNB1 PMC9688074__F6 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases MAPK14 TLR4 NKAP TRAF6 IL1B PMC9688074__F8 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases TGFBI NLRP3 IL1B PMC12027412__F9 Pathway enrichment analysis and protein–protein interaction among active components and common targets in prostate cancer SRD5A2 PTEN GRB2 PMC6978272__F8 How CSF induced accumulation of endosomes, autophagosomes, and lysosomes, which led to increased intracellular AB accumulation UVRAG APP IAPP PMC12027412__F4 Component–target–pathway–disease network diagram PIK3CA KLK3 CCND1 CTNNB1 PMC9688074__F1 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases TLR4 TRAF6 PMC9688074__F3 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases STAT3 NLRP3 PMC5412778__F2 Neural ectoderm and neural crest specification in deprivation of the external signals.A PAX3 SOX17 SMAD1 SOX2 GBX1 PAX6 ZIC1 MIXL1 CDX2 DKK1 OTX2 KRT7 GSC FOXA2 PMC7729224__F2 Cyclic adenosine monophosphate (cAMP)-cAMP response element binding (CREB)-miR-21- programmed cell death protein 4 (PDCD4) axis PTEN MTOR PMC2386254__F11 A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a Key Effector in the Response to DNA Damage HEL-S-62p ARHA NET1 PMC5949363__F7 Interaction between T follicular helper (Tfh) and B cells initiating synergetic effect of IL-21/IL-21R and CD40 ligand (CD40L)/CD40 to promote plasma cell differentiation and antibody production in EAE CD40 ICOS SYK BCR MOG PC HEL-S-11 PMC6289701__F2 Mammalian mTORC1-dependent ribosomal transcription CHD4 MAF POLI MTOR PMC7729224__F3 Wnt/Beta-catenin-c-Myc-miR-17∼92 axis NR1C1 MTOR CTNNB1 PMC7901767__F1 Evidence that a naturally occurring single nucleotide polymorphism in the RagC gene of Leishmania donovani contributes to reduced virulence SH3BP4 FLCN DEPTOR PMC1636614__F8 Schema of Ang II-induced NFAT activation in cardiac myocytes C6 NACA2 TRPC3 PMC5686148__F8 Working model CDC2 FOXM1 CDK2 PLK1 PMC9250990__F1 T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease IFNG CGAS APC PDC TLR9 IRF3 TLR7 PMC3042129__F8 Unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening KRT10 PCNA ANXA2 MMP17 SERPINA1 ANXA1 CENPE KIF23 SERPINB3 RB1 RAD21 CASP3 ENO1 RFC3 EEF1A1 F2RL1 MCM2 TOP2A HEL2 PS1TP5BP1 LMNA PMC9067156__F9 UDP‐glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines NR1C1 SNAI1 UGDH PLA2G15 PMC7865460__F1 Multiple myeloma (MM) cell metabolism compared to normal plasma cells HEL-S-133P LDHB PMC7865460__F3 General metabolic effects of MM-associated oncogenes CDK6 CCND2 GSK3B MAF FGFR3 MYC CCND1 CDK4 PMC4984448__F2 Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children PINK1 OPA1 MFN2 ATG5 PMC9177993__F1 Chromosomal synapsis defects can trigger oocyte apoptosis without elevating numbers of persistent DNA breaks above wild-type levels ATR HORMAD2 SPO11 PRKDC ATM PMC5131988__F2 Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy SRSF7 CAMK1 RPL12 WSB2 PPP3R1 RPL21 DOCK1 MAGOH PICALM FKBP5 TARBP1 EPHX1 NBPF10 RPS3 DGKD RGS5 MT1E USP46 PGRMC1 RPL26 CP PMC10975175__F2 Heat stress triggers nitric oxide (NO) production and increases calcium levels DCD NOA1 CS PMC5131988__F3 Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy CTF1 PPP3R1 LIF GSK3B NACA2 HAND1 SRC GATA4 CABIN1 PMC10889199__F1 Endothelial cell senescence CDK6 MTOR SIRT1 CDK4 PMC8275185__F11 Transcriptome Analysis of Chloris virgata, Which Shows the Fastest Germination and Growth in the Major Mongolian Grassland Plant DLK2 LAT SKP1 PMC4761146__F9 Schematic diagram depicting the proposed signaling pathway involved in interferon-induced transmembrane protein 1 (IFITM1) upregulation in SUM149 cells STAT2 IFNAR2 IRF9 IFITM1 TYK2 PMC7683115__F6 lncRNA-miRNA regulation mechanism diagram based on the insulin signaling pathway INSR INS PMC7683115__F7 lncRNA-miRNA regulation mechanism diagram based on the AGE-RACE signaling pathway STAT3 TGFBI PIM1 PMC1553448__F7 Transcript expression of BMP signaling pathway members TGFBR2 BMPR2 ID2 BMPR1A ID4 SMAD4 ID1 DCN ID3 TGFBR1 PMC11899777__F4 Comprehensive Review of Fc Gamma Receptors and Their Role in Systemic Lupus Erythematosus SYK BTK RHO SRC PMC5153335__F1 KRAS pathway biology ICMT BRAF RCE1 MTOR PMC4374654__F3 Emerging regulators of the inflammatory process in osteoarthritis EIF2A XBP1 IL1B PMC3936936__F1 Network of interactions between products of candidate genes from the QTL regions IF2B1 EPHA2 C1S PIK3CD HEL-S-7 PLG MTOR PTPN6 IFNG SERPINE2 STX11 IL2 PC APP LYN CCL20 PMC7218278__F1 “Confidence view” of the protein-protein interaction network on String.The thickness of the blue line between 2 nodes indicates the level of confidence of association between these 2 PPARG LCP1 LCP2 BPIFB2 CERS2 IL33 SOCS3 ESRRA RAP2A TYROBP SP3 REL CEBPB PMC7232545__F1 Anticancer mechanisms of matrine STAT3 EGF HMGB1 CASP9 BAD CASP8 PCNA EGFR GSK3B LRP5 PTEN MMP9 MTOR CTNNB1 CDK6 CASP6 ATG12 CASP3 MMP2 CDK2 ATG5 LEF1 TRAF2 CDK4 PMC9237220__F1 Different Immunoregulation Roles of Activin A Compared With TGFB SMAD2 SMAD4 MTOR PAX6 PMC7545984__F2 Pro-fibrotic roles of the GSK-3B signaling network in fibrosis ARRB2 CTNNB1 PMC3257109__F3 BMP signaling in motor neurons SMAD1 TRIO DKFZp781O1323 LIMK1 BMP2 SMAD4 BMP7 PMC8560861__F8 Model summarizing the pathway described in this study along with known effects of CCL20 and CXCL8 signaling in the context of cancer STAT3 CXCR1 CXCL8 CCL20 PMC6935755__F2 Ragulator complex in SEGAs RAF1 ATP6V1G1 ATP6V1A ULK1 LAMTOR4 BRAF PRKAG2 LAMTOR2 PRKAA1 BIRC5 ATP6V1D ATP6V1C1 ATP6V1C2 ATP6V1B1 RB1CC1 HEL-S-1 AKT1S1 LAMTOR1 RRAGA CASP9 ATP6V1G3 EIF4EBP1 ATP6V1F LAMTOR3 LAMTOR5 IRS1 EIF4E ARAF WDR83 RHEB MLST8 ATP6V1E2 TSC2 TSC1 RPS6KB1 PRKAG1 ATP6V1E1 PRKAG3 PRKAB2 PRKAB1 MAP2K2 SLC38A9 PMC7545984__F1 Anti-fibrotic roles of the GSK-3B signaling network in fibrosis SIRT3 SGK1 GSK3B BCL2 HEL-S-28 CTNNB1 PMC10982457__F1 Viral RNA‐driven peripheral serotonin reduction impairs neurocognition by directly dampening vagal signaling TLR3 ACE2 PMC3982501__F4 Receptor tyrosine kinase (RTK) signaling pathway is frequently hit by lentiviral vector (LV) integration MAP3K8 BRAF PTEN MDM2 GRB2 MTOR PMC10035551__F1 Regulation of PD-1 and PD-L1 expression in sepsis ZAP70 CD80 APC PMC10960957__F5 Ferrihydrite-mediated methanotrophic nitrogen fixation in paddy soil under hypoxia HPR GCK TNLG7C PMC6695603__F1 Epidermal growth factor receptor (EGFR) pathway in non-small cell lung cancer (NSCLC) EGF ERBB4 EGFR ERBB2 MTOR PMC6751247__F7 Schematic description of TLR7-mediated enhancement of CD8+ T cell function IFNG TLR7 IRF4 MTOR MYD88 PMC6695603__F4 Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC) ERBB3 CDC2 EGF ERBB4 EGFR AREG CDK9 PMC8764384__F1 Critical Roles of Proteostasis and Endoplasmic Reticulum Stress in Atrial Fibrillation ATF4 EIF2A XBP1 PMC8568770__F1 Endocannabinoid System Unlocks the Puzzle of Autism Treatment via Microglia GPR18 TRPV1 FAAH GPR55 PMC7798029__F1 Suppressive activity of MDSCs induced by the TLR2 and TLR4 signaling pathways STAT3 MPL S100A4 TLR4 S100A8 ARG1 JAK1 MYD88 PMC5613704__F1 Acute and chronic effects of plasma Ang II, aldosterone and EO on brain angiotensinergic pathways NTS BDNF AVP PMC6036268__F6 Pectin oligosaccharides (POS) downregulates the expression of nuclear factor-kappa B (NFKB) and COX-2 by binding toll-like receptor 4 (TLR4) TBK1 TLR3 TLR4 MAL IRAK1 TLR5 TNF MYD88 PMC7312564__F2 Proliferation and Differentiation of Adipose-Derived Stem Cells in Neovascularization and Angiogenesis C6 CEBPA PMC10030845__F2 Inflammasome and pyroptosis in autoimmune liver diseases GSDMD NLRP3 IL1B PMC10030845__F1 Inflammasome and pyroptosis in autoimmune liver diseases NLRC4 NLRP1 GSDMD NLRP6 NLRP3 TLR4 MYD88 PMC7982061__F2 Notch1 signaling pathway and Notch1 inhibitors CCND3 DLL4 JAG2 ADAM10 MYC FURIN DLL3 PMC4091181__F10 The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells GABARAPL1 PPARGC1A PMC6082390__F2 PC1/3 activity is essential to the leptin–melanocortin pathway POMC MC4R NPY ARC AgRP PMC6205410__F1 Four hyperglycemia-induced pathogenic pathways which are related to overproduction of ROS and inflammation progression in atherosclerosis CRP TLR4 HEL-S-162eP PMC11460135__F8 Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway BAX GPX4 HOXC11 PMC6205410__F2 Downstream products of ROS promote endothelial cells (ECs) dysfunction in atherosclerosis RHEB KLF2 MTOR PMC9204952__F9 Genome-wide association mapping and genomic prediction for pre‑harvest sprouting resistance, low Alpha-amylase and seed color in Iranian bread wheat TF BIN2 EBF2 PMC8126329__F1 Analysis of the Protein–Protein Interaction Network Identifying c-Met as a Target of Gigantol in the Suppression of Lung Cancer Metastasis ARVCF FAT4 GPC4 CDH19 CELSR1 PARVG MSLN ODZ1 PKP2 PCDHGC3 PCDHA9 PKP3 LAMC1 LAMB1 DSC2 BLK DSCAM PCDHB7 PKP4 ITGB1 PARD3 PLXNA1 LAMB2 PMC8001214__F3 Mechanisms of aging-associated salt-sensitive hypertension and crosstalk between Wnt noncanonical pathway and angiotensin II (Ang II)-induced vasoconstrictive pathway TPR ROR2 LRP5 LRP6 ARHA IL1B CTNNB1 PMC11120279__S1 FDT vaccine with the ability to activate systemic immunity for tumor inhibition APC IFNB1 MERTK PMC5490578__F7 Simplified diagram of the lipid metabolism canonical pathway TG APOD PON1 APOE PLTP PMC4865921__F9 Schematic summary of the results NGF CASP2 CASP3 LDLR PMC8463275__F2 Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy CDC2 FDXR FAS KIT MTOR MYC SSB CDK6 CDK12 CDK7 BRCA1 CDK2 CDK9 CDK4 PMC12001097__F4 Inflammatory cytokines and activation of PI3K/Akt pathway by Yiqi Jiedu Formula in recurrent Herpes Simplex Keratitis: Experimental and network pharmacology evidence PIK3CA EGFR PIK3R1 PTEN FGFR2 NGF COL1A1 TLR4 FGFR1 CHUK IL2 KDR CREB1 TNFSF6 IL4 VEGFA IL6 RAC1 FGF2 BRCA1 NFKB1 IKBKB ERBB2 BCL2 BDNF PMC4951304__F1 Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint DKK3 CDK6 CDK2 MYC CCND1 CDK4 PMC2564829__F7 Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells ATR ACACA PMC1971124__F4 BDCA2/FcERIG Complex Signals through a Novel BCR-Like Pathway in Human Plasmacytoid Dendritic Cells BLK ZAP70 SYK FYN BCR LAT PDC BLNK LYN LCK CARD9 PMC10956371__F1 UPR signaling pathway ATF4 EIF2A XBP1 PMC8085316__F2 Adapting T Cell Receptor Ligand Discrimination Capability via LAT LAT LCK PMC11555832__F4 Facilitating tumor cells recognition by innate immune cells CGAS TLR9 IRF3 IRF7 TRAF3 TRAF6 MYD88 RIGI TLR3 TLR4 TLR8 TLR7 TRAF2 PMC11555832__F3 Resistance to PD-1 blockade in CRC PTEN B2M PMC9240433__F8 Breast Meat Fatty Acid Profiling and Proteomic Analysis of Beijing-You Chicken During the Laying Period CD36 PPP3R1 SPHK1 ATP2A2 TECRL SLC25A4 ABHD2 ACAT1 APOA4 PHKB PLA2G7 CPT2 PECR ACOT7 TNNC1 TNNC2 ABCD2 ANXA1 ACSL1 ECHDC1 SLC37A4 FABP5 CASP3 APOB ACADL CPT1A PMC3928697__F5 Proposed pathway of CD33 siglec-mediated suppression of cellular function in Leishmania infection IFNG CD33 SOCS3 SIGLEC5 PMC7836502__F6 Production of PA and DGPP by different pathways and interconversion reactions mediated by phosphorylation and dephosphorylation LPA CA7 CA8 CA3 CA12 PI3 PC HEL-S-11 CA9 OCRL PMC3070284__F2 Endothelial growth factor receptor (EGFR) signaling pathway EGF EGFR GRB2 MTOR PMC8814392__F2 Restoration of miR-223-3p expression in aged mouse uteri with Samul-tang administration FUT4 BDH1 SPHK1 CD7 IPPK CTSC CXCL3 MME HAL ALOX15 PTGFR CYP26B1 GSTM2 CD2 CTSW P4HA3 AP3B2 HSD11B1 LIPG GNA15 NAPSA HDC PAPSS2 B3GNT5 PIGA FBP2 HEL-S-130P PHGDH ALDH1A2 ADA PMC7399786__F7 Roles of miR-33a and its target genes in prostate (top) and breast cancer (bottom), and the underlying mechanisms EN2 ROS1 HADHB PIM1 ADAM9 EZH2 CPT1A EIF5A2 TGFBR1 PMC6242703__F1 Simplified diagram of transcriptional pathways and targets for intervention for AUD treatment CORT NPY BDNF PMC6592474__F8 Endoplasmic reticulum stress is involved in spiral ganglion neuron apoptosis following chronic kanamycin-induced deafness ATF4 XBP1 TRAF2 PMC4950926__F6 Schematic presentation of mechanisms of actions of CTS TPM1 MYOG MYOD1 IGF1 PMC7688141__F8 Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway KLF4 SOX2 PMC5955995__F4 MAPK Signaling pathway showing expression pattern of DEGs in Ladakhi and Sahiwal cows ECSIT EGF JUN FAS MAPK11 MAK RASGRF2 BRAF CD14 PRKCZ MINK1 KRAS FOS MEF2C PRKCH MAPK14 CRK NTF4 NF1 SOS2 MAPK12 NLK MIP OPTN PMC8269279__F6 Roles of Pseudophosphatases in Disease CDH2 STYX FBXW7 STYXL2 CELF2 PMC1069621__F5 Two models for coupling of circadian and cell cycles ATR ATRIP TIMELESS CRY2 WEE1 PMC3525180__F3 Some perifosine-specific genes are connected by common pathways leading to MAPK signalling pathway and apoptosis NFATC4 MAPKAPK3 MPDZ IGF1R ATF2 PMC8251784__F4 In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae NOD2 CD207 PMC4694853__F8 Non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation RPS6 MTOR PMC4891982__F4 Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage ME3 ME2 MAL PC CIT PMC6790656__F3 Biological applications of light‐induced dimerization systems C2 CRY2 ARHA RAC1 PMC12115990__F3 TRIM25 regulates the RIG-I- and MDA5-mediated antiviral and TRAF2/TNFA signaling pathways MAVS TRIM25 IRF3 TRAF3 TRAF6 TNF TRAF2 TRIM65 PMC7139810__F7 Reciprocal link between the serine biosynthesis pathway (SBP) and MYC oncogene PHGDH EZH2 PSAT1 ATF4 PMC12115990__F2 Biological functions of TRIM25 in SARS-CoV-2 infection and cancer cell survival MAVS TRIM25 KEAP1 GPX4 IRF9 MAF TFEB IRF3 IRF7 MDM2 PMC1774101__F4 Proposed framework for recruitment of T cells into the gut mucosa by activated CD40L+ platelets CD40 CCR5 CCR3 VCAM1 PMC4055851__F2 Resistance to anti-EGFR moAbs in mCRC EGFR PTEN MTOR PMC3616974__F6 Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB KPNA3 TAB3 DLEU7 KCNRG PMC6779808__F6 Network analysis from RNA seq NPAS1 HEL-S-103 RAD52 FOXJ1 ZNF74 HSPA14 NBPF3 TNFRSF10D EXO5 NFE2 UBTF TUT4 RBM5 PMC8869286__F1 Identification of Targetable Liabilities in the Dynamic Metabolic Profile of EGFR-Mutant Lung Adenocarcinoma: Thinking beyond Genomics for Overcoming EGFR TKI Resistance HGF EGFR FASN LDLR PMC6156122__F2 Pathways to retinal regeneration LAT SIX3 ASCL1 CTNNB1 PMC10260623__F1 Schematic of the clock pathway TF NPAS2 DBP NR1D1 PMC8044762__F2 cGas-STING activation pathway ATG9A IRF3 ENPP1 PMC8372643__F2 HIF1Alpha-PFKFB3 Pathway in Diabetic Retinopathy F2 DLL4 HIF1A PMC5600417__F1 GO biological process and KEGG pathway enrichment analyses of the differentially modulated proteins at 6 and/ or 12 h of treatment with A233 peptide MAVS HEL-S-97n VCP AKR1B1 COXFA4 NABP1 ACAT1 HADHB HEL-S-128m HSPD1 HEL-S-32 ARHGEF2 HEL-S-44 BAX ECHS1 EEF1E1 HK2 NABP2 LDHB FABP4 PCK2 DLAT FCER1G RUVBL2 NDUFA2 PFKL PMC8372643__F3 HIF1Alpha-PFKFB3 Pathway in Diabetic Retinopathy F2 APC PMC2212359__F5 HToll and TNFR-1 signaling pathways TRADD ATF2 TRAF6 TRAF2 MYD88 PMC209410__F1 The EXT proteins and HS biosynthesis GAL EXT2 EXTL2 CS EXT1 PMC9682092__F4 LncRNAs involved in regulating the RIG-I signaling pathway MAVS IRF7 PMC9682092__F3 LncRNAs involved in regulating the RIG-I signaling pathway TBK1 MAVS IRF3 IRF7 TUG1 PMC6262346__F1 Metabolic pathways involved in glucose, fructose, and xylose catabolism in B HEL107 RPE RPIA XYLB PMC209410__F2 A working model of mammalian bone development EXT2 IHH SMO EXT1 PMC9682092__F2 LncRNAs involved in regulating the RIG-I signaling pathway MAVS STAT2 MAK IRF9 SFPQ IRF3 IRF7 STAT1 GSTM1 TRIM25 IFNAR2 IFNAR1 JAK1 TYK2 PMC8884404__F1 Molecular Pathways of Pyroptosis in Atherosclerosis GSDMD NLRP3 AIM2 ARHA PMC9682092__F1 LncRNAs involved in regulating the RIG-I signaling pathway TBK1 MAVS TRIM25 IRF3 IRF7 TRAF3 PMC3227927__F1 Signaling pathways and effects of EGFR EGF HBEGF TGFA EGFR PTEN PMC8998691__F3 MicroRNAs Expression in Response to rhNGF in Epithelial Corneal Cells: Focus on Neurotrophin Signaling Pathway CDC42 TP73 PIK3CA BAD SHC1 AKT3 BRAF IRAK1 NTRK3 PSEN1 TRAF6 NGF PLCG1 SHC4 RIPK2 NTF3 PLCG2 HEL2 BAX JUN CRKL TNFSF6 MAPKAPK2 KIDINS220 NTRK2 PTPN11 ARHA KRAS RAC1 IRS1 CRK ARHGDIB MAP3K1 RELA NFKBIA CALM1 BCL2 MAP2K5 RPS6KA3 MAP2K1 GRB2 PMC9368823__F2 Cell Signaling Pathways and Non-Coding RNAs by Baicalein in Different Cancers RHEB TSC2 RICTOR TSC1 DDIT4 PMC8998691__F2 MicroRNAs Expression in Response to rhNGF in Epithelial Corneal Cells: Focus on Neurotrophin Signaling Pathway MGA PMC9368823__F1 Cell Signaling Pathways and Non-Coding RNAs by Baicalein in Different Cancers FZD4 APC GSK3B LRP5 LRP6 TCF4 FOXA2 CTNNB1 PMC4126464__F10 Metabolic redistribution in Synechococcus sp IPP MAL CIT PMC3728221__F8 Working model for the synergistic effect of TPL and ATF on tumour cells BAX CASP9 CASP3 SKP2 CCND1 FADD PMC8872821__F1 Chemokine CCL1 as a therapeutic target for pulmonary fibrosis: comments on ‘The chemokine CCL1 triggers an AMFR‒SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis’ AMFR SPRY1 CCL1 PMC8280127__F8 HOTAIRM1 working mechanism ROCK1 BCL2 ARHGAP18 ARHA BCL2L11 PMC8069526__F5 RNAs that regulate nonhomologous end-joining (NHEJ) SBF2 PMC4277354__F6 ReNE: A Cytoscape Plugin for Regulatory Network Enhancement HTRA2 GNAI1 CASP9 REST PINK1 PPIF HEL-S-67p CYCS GNAL SNCAIP SDHA DRD1 NR2A1 DRD2 HSF1 CREB1 PMC6604468__F7 MUC17 inhibits the progression of human gastric cancer by limiting inflammatory responses MUC17 CDX1 RHO PMC5705614__F1 The core elements of the mammalian Hippo signaling pathway LATS1 HEL-S-31 CDC2 MOB1A MOBKL1A LATS2 MAP4K3 MAP4K1 MAP4K2 VGLL4 PMC5705614__F3 Schematic depicting the mechanical regulation of the mammalian Hippo signaling pathway AMOT ARHA RAC1 PMC5705614__F2 Schematic depicting the hormonal regulation of the mammalian Hippo signaling pathway LPA AMOT APC ARHA RAC1 PMC5705614__F4 Schematic depicting the metabolic regulation of the mammalian Hippo signaling pathway AMOT ARHA RAC1 PMC4467156__F12 New chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras FGFR1 GRB2 FGFR2 PMC7801429__F2 An ER signaling pathway network identified by IMPALA using Loi breast cancer gene expression data SOCS1 STAT3 SHC1 ITGB4 EGFR PTPRC KHDRBS1 GMFB MAPK14 PLCG1 YWHAQ INSR BCR WAS PRKCA CHUK CSNK2A1 HEL-S-1 SRC HDAC2 CREB1 TOP2A MAPK1 JUN SORBS3 PTPN11 TUBB FOS IRS1 CRK TSC2 PRKCI CASP3 ERBB2 CREBBP PTPRE JAK1 LYN GRB2 PS1TP5BP1 LMNA YWHAZ LCK PMC7385185__F11 The two-way communication between AMs and AECs in LPS-induced airway inflammation IGF1 TLR4 IL1B PMC7503879__F6 Insulin/FoxO signaling pathway in silkworm diapause eggs at onset of diapause IGF1 PDK2 INS PMC4939711__F1 Oncogenic signalling and nutrient availability influence cell metabolism ACLY GLS HEL-S-133P FASN HIF1A MYC KRAS PMC4213571__F2 Model depicting Tax-induced shuttling, localization and activation of canonical and noncanonical NFKB signaling pathways PDLIM2 RNF4 MCL1 IL17RB RELB USP20 TRAF6 OPTN CYLD PMC4939711__F3 Complex, compartmentalized pathways of NADPH production MTHFD2 MTHFD1 F2 SHMT1 MTHFD2L TIGAR MYC HEL-S-51e PMC8102819__F2 Immunopathology of Acute Kidney Injury in Severe Malaria IL13 VCAM1 TNF PMC4939711__F2 Catabolic pathways support metabolism during nutrient stress ACSS2 BRAF CS KRAS PMC4568025__F2 Interaction network for human CIBLIN transcriptional regulators GCM1 NFATC2 NKX3-2 SOX10 GABPB1 MYC NFE2 MED29 SOX9 ETV6 FOXC2 MSR1 MYCL NRF1 HES1 NFE2L3 NPAS2 RHD ZNF488 MED30 FOSB PHTF1 MNT GLIS1 TCF21 FOS NKX3-1 MED24 TFAM GBX2 ESRRB PPARGC1B GSX1 L3MBTL1 FOXL1 SOX8 MNX1 MED26 RFX5 USF2 NFKB2 RELB YLPM1 LBX1 HOXA2 AFF1 MSL3 GATAD1 CBFA2T2 PLAGL1 PFDN1 AEBP2 L3MBTL4 CREBL2 MED16 ZNF146 MSC POU6F2 HOXB2 TCF15 ZNF292 RREB1 MED28 BACH2 NFATC4 AFF4 PLAGL2 NFATC1 MED1 ID1 ID3 GLIS3 ESRRA LMO4 MED9 MTF1 NFKB1 NFAT5 NFE2L2 NFATC3 MED25 PMC7394371__F3 Gene expression profile analysis of the rabbit retinal vein occlusion model BAD LTA COX2 LAT MAK INA FRK MEN1 ADK CS DAO TRAF2 PMC3644335__F2 Cryptosporidium parvum scavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes ABCG8 ABCG5 NPC1L1 LDLR PMC10525124__F2 Oxidative Stress in Liver Pathophysiology and Disease NOX5 KEAP1 DUOX1 DUOX2 NOX4 PMC3941591__F5 ‘Ephrin Receptor Signaling’ was the second canonical IPA pathway induced in LR rats upon FST exposure RAF1 SHC1 GRB2 PMC5569090__F11 Schematic presentation of the mechanism for shell biomineralization mediated by the TGFB/BMP signaling pathway in molluscs BAMBI BMPR2 SMAD1 DKFZp781O1323 SMAD4 PMC3941591__F4 Top Ingenuity networks of genes whose expression was significantly altered in the hippocampus upon FST exposure LDOC1 STXBP1 SMAD1 DKFZp781O1323 RAB7A AGAP2 SMAD2 NMB PTMS RGMA RHO MGLL VAMP7 OGG1 REV1 NOG RAD17 MSI2 ZNF24 RIPK1 FAM118A LARP4B CACNB3 FEN1 NEU3 RNF11 SOX2 RPS27A PACSIN1 PC4 TUBB EEA1 RBBP8 PABPC1 STXBP5 ITSN2 ACTL6A LIN7A APLP1 HOMER2 PMC11772949__F3 The RLR adaptor MAVS mediated by protein palmitoylationIn the RLR signaling pathway, CPT1A interacts with ZDHHC4 to promote MAVS palmitoylation at Cys79 TRIM31 CASP8 MAVS ZDHHC7 RIPK1 ZDHHC4 ZDHHC24 CPT1A RAC1 PMC4133210__F1 Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells ATF4 EIF2A TRIB3 XBP1 PMC6972624__F10 Proposed model RBX1 MYC DAO PMC10758544__F9 Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NFKB signaling pathway CTSK NFATC1 MMP9 PMC3564018__F10 Stress-suppressed genes involved in antigen presentation and synapse formation TH CD2 CCR5 HEL-S-269 CD14 TNF HEL-S-99n IFNG CD58 MHC2TA TLR4 CCR7 IL2 TAP2 PMC10243851__F1 Clinical, genetic, and immune landscape of meningioma in patients with NF2-schwannomatosis LATS1 RHEB CD44 TSC2 LATS2 TSC1 IRF3 CTNNB1 PMC7477642__F2 Selected pathways relevant for plausible salvaging of residual ovarian function in primary ovarian insufficiency RAD51 KIT PTEN AMH MTOR PMC8771833__F4 Slit/Robo Signaling pathway in Bone Metabolism ROBO2 ROBO3 SLIT3 SLIT2 ROBO1 PMC3149740__F5 Mammals have two distinct but ultimately converging pathways to apoptosis BAX BAD TRADD BOK BMF HRK BIK FADD PMC2898443__F1 The eukaryotic 80 S initiation pathway EIF4B ELF2 EIF4H EIF5 EIF5B ELF5 ELF3 PMC8771833__F5 Slit/Robo Signaling pathway in Bone Metabolism CDC42 ROBO3 CDH2 SLIT2 ROBO1 RAC1 CTNNB1 PMC7403683__F1 Conditional reprogramming (CR) culture system and the potential molecular mechanisms of CR CD44 HBEGF RHO MTOR GAB2 CTNNB1 PMC7530640__F1 Role of microglia and canonical NLRP3 inflammasome in Alzheimer's disease HMGB1 GSDMD NLRP3 IL1B PMC6197541__F1 Associated cell signaling pathway and related potential therapeutic areas SMAD4 HIF1A PMC5293201__F1 Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective KEAP1 EGFR ALAS1 FTMT PMC8990295__F3 Cancer metabolism challenges genomic instability and clonal evolution as therapeutic targets SIRT3 GPX4 SLC7A11 HIF1A SIRT6 PMC7884075__F4 GWAS hits in the IGF-1 pathway STAT3 SHC1 INSL4 INS-IGF2 SOCS2 PTEN IGF1R PI15 GH1 INS THRA IGF2R RASA2 PI3 RABEP2 RAB3D INSL6 SH2B1 GHB2 GHR RAB3IL1 RAB26 RIN2 IGFALS IGF2 IRS1 GHSR IGF1 PMC8257068__F1 Prospect of CDK4/6 Inhibitors in Triple-Negative Breast Cancer RHEB TSC2 CDK6 DEDD CDK2 PTEN CDK4 PMC9468713__F7 Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IKBA–NFKB p65 Complex CTSK NFATC1 TRAF6 PMC5866851__F2 Visual description of the IL-31 and IL-33 cascades leading to the activation of the genes and the proteins involved in the development of inflammatory disorders CCL24 CCL3 OSMR IL33 CXCL2 CCL5 CCL2 TNF IRAK4 CCL17 MYD88 PMC7847103__F1 Subgroup specific actionable molecular pathway in MB TGFBR2 SUFU SMAD2 APC GSK3B SHH SMAD4 SMO CTNNB1 PMC7547805__F2 Regulatory mechanisms of TEAD in cancer biology LATS1 LATS2 AXL IGFBP5 SOX2 IRF3 TCF4 MMP9 MYC TEAD4 PMC5557384__F5 Insulin-induced PI3K-Akt and MAPK network in hepatocytes ACLY BAD SHC1 SOS1 GYS2 FOXK1 LARP1 MTOR IRS1 EIF4E RHEB TSC2 TSC1 GRB10 GYS1 AKT1S1 GRB2 PMC10536768__F4 Innate Immune Response to Viral Vectors in Gene Therapy CGAS TLR3 IFNAR1 IRF3 IRF7 TRAF3 MYD88 PMC3590592__F6 Proposed schematic representation of Wnt5a/Beta-catenin signaling in keloid pathogenesis APC GSK3B CTNNB1 PMC10536768__F3 Innate Immune Response to Viral Vectors in Gene Therapy TBK1 CGAS TLR9 IRF3 IRF7 MYD88 PMC10536768__F2 Innate Immune Response to Viral Vectors in Gene Therapy TBK1 CGAS TLR4 IFNAR1 TLR9 IRF3 IRF7 MYD88 PMC2195651__F1 Fas (death receptor) signaling pathway and its inhibition HRAS FAS FADD PMC2531163__F3 Developmental signaling pathways SUFU APC SMO MYC CTNNB1 PMC4919901__F2 Allergic Mechanisms of Eosinophilic Oesophagitis TGFB1 MBP APC PMC11772949__F8 Modulation of JAK-STAT signaling by palmitoylationIn the JAK-STAT signaling pathway, JAK1, JAK2, STAT1, STAT3, and STAT5A can be palmitoylated STAT3 STAT2 CD36 GSK3B ZDHHC4 CXCL10 ZDHHC3 STAT1 GFAP ZDHHC12 ZDHHC7 ZDHHC21 IFNAR1 ZDHHC5 JAK1 ZDHHC8 ZDHHC23 PMC3146606__F2 PARP function in base excision repair and consequences of PARP inhibition RAD52 RAD50 RAD51 MRE11A PARG BRCA1 ATM SSB PMC9448771__F8 Graphical abstract. NAT10 functions as a negative regulator of neutrophil pyroptosis and a protective factor in sepsis NLRP3 ULK1 NAT10 IRF3 PMC12092303__F2 Molecular targets and mechanisms of O-GlcNAcylation in the central nervous system OGA TH STAT3 OGT SOX2 SHH ARHA AgRP MTOR PMC3022188__F1 Rationale for dual treatment targeting the IGF-1R signaling pathway in RMS IGF1R MTOR IRS1 PMC11772949__F5 RLRs induced by protein palmitoylationNLRP3 palmitoylation is induced by ZDHHC7 but suppressed by ABHD17A at Cys126 ABHD17A ABHD8 CD36 ZDHHC1 FASN SQSTM1 ZDHHC12 ZDHHC7 NLRP3 PPT1 NOD2 NOD1 ZDHHC5 PMC9052535__F1 Integrated regulation of chondrogenic differentiation in mesenchymal stem cells and differentiation of cancer cells SMAD1 DKFZp781O1323 SHC1 SMAD2 APC LRP5 SMAD4 LRP6 RUNX2 RBPJ COL2A1 CTNNB1 ACAN SOX6 MAP3K7IP1 SOX9 SUFU SMO GRB2 SOX5 PMC11772949__F7 Pattern recognition receptor signaling by palmitoylation GSDMD NLRP3 ZDHHC7 ZDHHC9 IL18 ZDHHC5 ZDHHC14 PMC4605373__F4 Apoptosis response pathway HELLS BAD LTA FAS TRADD CYCS BBC3 TRAF3 MYC IKBKG CDKN2A BCL2L2 MAP2K4 CASP4 BOK CHUK MDM2 TNFRSF21 CRADD HRK BAX CASP9 JUN CASP2 TNFSF6 IRF3 IRF7 TNF IGF2 SET RELA IKBKB IRF2 CASP3 DFFA MAPK10 BIRC2 TRAF2 NFKBIB DIABLO FADD PMC11772949__F6 Pattern recognition receptor signaling by palmitoylation CDC42 ZDHHC20 CGAS MAVS CD36 TNF MYD88 RAB27B ZDHHC7 ZDHHC9 NRAS NOD1 ZDHHC5 PMC12092303__F1 Main physiological functions of O-GlcNAc in the central nervous system OGA STAT3 OGT SOX2 PMC5733947__F4 miR-155-5p and miR-200a-3p greatly influence TLR4 signaling pathways TBK1 EED TIRAP IKBKE SMAD2 HSD17B11 KIF20A TRAF3 TRAF6 SPI1 IRAK4 IKBKG MAPK3 MYD88 MAP3K8 CDK6 IFNA1 IL1B JUN TICAM2 EZH2 IRF3 IFNA2 FOS NFKB1 RELA IKBKB EP300 MAP2K1 MAP2K2 PMC3364444__F1 N-BPs may modulate myeloma progression through their effects on the mevalonate pathway and directly on MM plasma cells, bone marrow cells and immune cells in the bone marrow IGF1 RHO TNF PMC5312381__F7 MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway ARHGAP5 ARHA CXCR4 PMC9502927__F1 Targeting Ceramides and Adiponectin Receptors in the Islet of Langerhans for Treating Diabetes CERK tmp_locus_29 PMC8658460__F10 Crosstalk between E-Cadherin/Beta-Catenin and NFKB Signaling Pathways: The Regulation of Host-Pathogen Interaction during Leptospirosis MMP7 CTNNB1 PMC10136030__F4 In the nucleus, TERT performs both canonical (elongates telomeric ends) and non-canonical functions (participates in the regulation of gene expression) BAX ATR ATM TERT CCND1 PMC10136030__F3 TERT is involved in major signaling pathways and participates in regulation of gene expression BAX BAD TERT PMC3686618__F6 Main signaling pathways supposed to be activated in MEC exposed to either E LTA TLR4 IRF3 CXCL10 CXCL8 CCL20 MYD88 PMC10136030__F2 Classification of BCL-2 family proteins and their role in the regulation of the internal pathway of apoptosis BAX BAD BOK BMF HRK BIK PMC10136030__F1 Structure and functions of telomeres ATR ATM TERT POT1 TPP1 PMC7436626__F1 Role of H2S in lung inflammation KEAP1 IL6 IL1B PMC8232755__F7 DLX Genes: Roles in Development and Cancer SP1 HMGCR PMVK CTNNB1 PMC3003905__F5 Spontaneous-fusion-mediated cell reprograming is controlled by Beta-catenin levels in ESCs and not by their proliferation WNT3A C2 CTNNB1 PMC3744901__F9 Regulation of RB/E2F pathway EGF PTEN MDM2 CDK4 PMC4313578__F3 Therapeutic Targeting of Autophagy: Potential and Concerns in Treating Cardiovascular Disease RHEB MLST8 TSC2 TSC1 IGF1 FOXO1 FOXO3A F3 DEPTOR PMC6728578__F9 Key proteins involved in the DNA damage response (DDR) following DNA double-strand breaks (DSBs) ATR RAD50 MRE11A BRCA1 H2AX ATM MDC1 PMC8005589__F1 Rationale to target mechanistic target of rapamycin (mTOR) in renal cell carcinoma (RCC) RHEB TSC2 TSC1 PTEN VHL PMC3520048__F2 Summary of the role of the mammalian target of rapamycin (mTOR) signaling pathway in the development of tuberous sclerosis complex (TSC) and inhibition by mTOR inhibitors RHEB EEF2K TSC2 EIF4B RICTOR TSC1 IRS1 EIF4E PMC7704201__F1 In the insulin signalling pathway, insulin attaches to insulin receptors triggering its dimerization and the intracellular autophosphorylation of their tyrosine residues, which constitute an attachment for IRS proteins PI3 IRS1 PMC5064357__F6 Novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes PIP5K1A DGKG IRS1 PMC7704201__F3 Nrf2/Keap1/ARE pathway in T2DM KEAP1 MAF PMC5969374__F4 Disrupted signaling pathways in GCB-DLBCL TNFRSF14 S1PR2 GC BCL2 EZH2 BTLA ARHA MTOR MYC BCL6 PMC9103477__F1 Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma CYP21A2 STAR CYP17A1 GNRHR MC2R PMC6111036__F11 D5R mutation induces dilated cardiomyopathy that is related to oxidative stress PLN BAX KEAP1 PMC5969374__F5 Disrupted signaling pathways in ABC-DLBCL CD40 SYK CD79A BTK BCL10 BCR CARD11 IRF4 MTOR BCL6 MYD88 PMC3230300__F2 Mucins in the Pathogenesis of Breast Cancer: Implications in Diagnosis, Prognosis and Therapy BAX EGF EGFR ERBB2 DAO PMC3866868__F2 Nodal pathway activity in the determination of L–R asymmetry LEFTY2 NODAL PITX2 PMC5244336__F9 The mechanisms by which PRRSV infection upregulated miR-373 expression and miR-373 facilitated PRRSV replication SP1 STAT2 IRF9 IFNAR1 IRAK1 IRF1 IRAK2 IRAK4 PMC8508344__F1 Estrogens and the Schrödinger’s Cat in the Ovarian Tumor Microenvironment HSD3B2 CYP17A1 CYP11A1 HSD17B1 STS PMC8775994__F3 Photic Entrainment of the Circadian System JUN SIK1 PER2 PER1 FOS PMC5346293__F2 Signal pathway integration that regulates Hsp90 expression STAT3 STAT1 HSF1 STRAP PMC7356240__F1 Macrophage migration inhibitory factor (MIF) mediates immune response crosstalk in dengue pathogenesis CD44 CD74 MIF MMP9 IL8RB CXCR4 PMC7985549__F1 Several ligands on the cell surface stimulate the production of PIP3 (phosphatidylinositol trisphosphate) by PI3K EGFR APC GSK3B PTEN CTNNB1 PMC6120164__F1 Network of “Target-Pathway” in osteosarcoma (OS) based on the collected data from – MTCH2 RAB10 TNKS2 EGFR MCL1 VAMP3 TLK2 IRAK1 CBX1 TYMS LAMC1 RORA MAST2 NUFIP2 DCP2 CCNJ SGPP1 TARP AAG1 KDR PTPN4 DYRK2 EFNB2 NXPE3 TEX2 STK17A AGO1 RRAGD REEP3 SERP1 RUFY2 PERP SCD TWF1 NUP160 SKI PARP1 IFT52 ZNF264 SNTB2 PFAS MMD PMC4928587__F5 Proposed model for the role of PALB2 in linking BRCA1 with BRCA2 and RAD51 in a pathway of HR RAD51 BRCA1 BRCA2 PALB2 PMC4001855__F1 Glycosylation of the nuclear pore OGA OGT PMC11946485__F1 PI3K signaling pathway inhibition and antitumor immune synergistic therapy strategy TH HEL-S-92n STAT3 FOXP3 PMC11993743__F9 The potential of the SA8-E6-12 antibody cocktail to modulate immune responses activated by S100A8 BAX TLR4 S100A8 MYD88 PMC8273570__F1 Three modes of IL-6R signaling and their associated intracellular pathways SOCS1 STAT3 SOS1 SOCS3 GRB2 PMC6163404__F1 Brief overview of canonical and non-canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) activation pathways RELA RELB TNF PMC9068921__F7 Mechanism graph of the regulatory role of circ_0000811 in cerebral ischemic vertigo STAT1 PMC8668291__F1 Plant-Derived Chinese Medicine Monomers on Ovarian Cancer via the Wnt/Beta-Catenin Signaling Pathway: Review of Mechanisms and Prospects APC LRP5 LRP6 CTNNB1 PMC11946485__F5 Development of PI3K inhibitors represents a promising strategy to enhance the efficacy of cancer vaccines through the modulation of immune responses CD80 BCR APC CCR7 IL4 PMC2887830__F2 Regulation of intracellular Stat3 signalling STAT3 CXCL12 IL10 HIF1A MMP9 SOCS3 IL6 FGF2 COX2 MMP2 IL11 TWIST1 CCND1 PMC11946485__F2 Regulatory role of PI3K signaling pathway in immune cell function STAT3 BAX BAD BCR BCL6 PMC11619421__F6 PPI network of associated pain-related genes enrichments in KEGG pathways and tissue expression DVL1 ADRA1D MYC GNAS SHANK1 GRIK5 PDPK1 PDE1B GRIN3B GRIP1 WNT4 PDE4A ROR2 OLIG2 FOS SST TBR1 ERBB3 GNA14 RPS24 RPN2 FZD4 CHRM2 ADCY3 RPN1 EEF2 PICK1 AVP VAMP2 HTR4 ADRA1A PIP5K1C CRH FBXW11 CNP VSX2 GRID2 CTNNB1 SCN10A CACNA1I BCAN POU4F1 CALB1 WNT9A FZD1 CACNA1S GPC1 EGR1 GDNF GNB5 PDGFA BIN1 FZD9 GABRB3 AXIN2 FGF2 INVS INPP4A DRD5 NTRK1 LEF1 CAMK2G PMC9270260__F12 Novel antiproliferative PKCAlpha-Ras-ERK signaling axis in intestinal epithelial cells HRAS SOS1 RASGRP3 GRB2 CCND1 ID1 PMC5950532__F6 Protein-protein interaction analysis of HOXA13-related genes in the first four Kyoto Encyclopedia of Genes and Genomes pathways PPARG EHHADH ROCK2 EGFR LOC51064 GNG12 EVI1 TWIST2 PTEN GNAL PEX2 PEX11B KITLG PEX13 HOXD10 CD44 NR1C1 RALB CAMK2D ARHGEF12 PRKCA GNA11 FZD1 CAMK2G PMC8922271__F5 Organelle interfaces by ER‐resident E3s TMEM43 ENDOD1 TMED1 UBE2G2 USP15 UBE2J1 RNF5 ERLIN1 TMEM33 SEL1L RNF170 INSIG1 PMC11638664__F6 Schematic synthesis of data and hypothesis ATOH1 EGFR APC GPR49 CTNNB1 PMC8491218__F3 Pathway‐extended gene expression signatures integrate novel biomarkers that improve predictions of patient responses to kinase inhibitors PRKD2 MYB SOS1 WASF3 PAX4 SLCO3A1 NTRK3 FSHR CDK6 FYN SNAI1 PAX2 TPD52 GC SHH ABCC2 CREB1 ABCB1 FURIN SIAE TCF3 PALM TSC1 FZD4 CDKN1A CYP2C9 BCL2 FOXL1 HNF1A CCL20 VEGFC VAMP2 NRG3 SHC2 SLC26A2 PRKCB AHR CYP17A1 CPNE6 MRGPRF UTP20 CGB7 ZNF780A SLC4A9 RUNX1 HSD17B2 ERBB2 ENPP2 LYN LEF1 PS1TP5BP1 LCK PMCH GCM1 CSF1 EPHA2 IL3 DDR2 COL17A1 TNNI1 BCL2L1 BAG2 MEIS1 BMPR2 AXL PLG FGF10 HEL-S-78p SLC24A2 SULT1E1 GRB7 FOXO1 RUVBL1 WASF1 RET TP73 SLC3A2 HEL113 FZD10 PIK3R3 RELB IGF1R TRIM68 PLAT CYP2C19 INSR GRM3 BAX LIF FZD7 COL14A1 CXCL2 MMP9 PTGS2 GNG3 GCG NRG1 HMGA1 NFKB1 CACNA2D1 CYP3A4 FFAR2 PMC10380296__F7 Transcriptional Modulation Reveals Physiological Responses to Temperature Adaptation in Acrossocheilus fasciatus SYK BAD PTEN CD19 RAC1 IRS1 TSC2 BOLL BCR RHOB PI3 RXRA COIL MDM2 PMC10380296__F6 Transcriptional Modulation Reveals Physiological Responses to Temperature Adaptation in Acrossocheilus fasciatus POR EGF HEL-S-133P EPO CYC1 GLA HEL-S-87p PMC8491218__F1 Pathway‐extended gene expression signatures integrate novel biomarkers that improve predictions of patient responses to kinase inhibitors TPM1 GPC4 AGO2 LCOR AFP PAX4 ANK2 TTN ABCC2 RET PMC10380296__F5 Significantly DEGs identified by KEGG in protein digestion and absorption pathways (ko04974) CTRL LAT2 NACA PMC2839260__F1 Schematic depiction of the signalling pathways stimulated by cholecystokinin (CCK) activation of the CCK1 receptor CCK EGFR MAPKAPK2 MAPKAPK3 GRB2 MTOR SHE EIF4E PMC7985550__F1 PI3K signaling pathway and related target drugs in endothelial cells MTOR FSHR PMC7072849__F9 Visual summary of the main findings of the study KRT18 SOX17 CDH2 FOXA1 FOXJ1 TBX6 SOX2 NODAL MIXL1 CTNNB1 FOXF1 LEFTY1 CER1 SHH GSC FOXA2 SOX5 NOTO PMC6909953__F2 E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes HEL-S-99n CANX EBP BCL2 AMFR ATF4 XBP1 VCP TRAF2 PMC12052884__F1 Metformin in gynecological disorders: pathogenic insights and therapeutic implications TLR4 MTOR SIRT1 PMC7307862__F2 Various classes of lncRNAs EED TBX20 EZH2 NKX2-5 TBX5 PMC4117608__F6 Israeli Acute Paralysis Virus: Epidemiology, Pathogenesis and Implications for Honey Bee Health HEL164 GSK3B VNN2 SNRPF TGFBR1 POR PIG59 RPS13 NDUFS6 SRPK2 ABCB1 PSMD6 PSMD4 TUBA1A ACTN1 MED15 JUN CAD PGLYRP1 LMAN2 PTPN1 POLR2H SFT2D1 KATNB1 ARGLU1 POLR3E HPGD UQCRFS1 HEL-S-162eP SSRP1 BMP2 ATP6V0B SMU1 PMC4856760__F8 Working model of the regulation of the type I interferon and NFKB signaling pathway by TRIM9s TBK1 CGAS MAVS IRF3 PMC7985550__F3 PI3K signaling pathway and related target drugs in vascular smooth muscle cells IGF1 FOXO3A BMP4 PTEN RUNX2 INS PMC4473797__F1 E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses CD14 IRAK1 IRF3 IRF7 IRAK4 MYD88 PMC5582844__F7 Proposed model depicting cross-talk between Gq-coupled GPCRs and CLEC-2 pathways DUSP3 TPR SYK PLCG2 PMC3334516__F4 TGFB signaling pathway members and potential pathway member LRG1 MAPK1 C6 HMFT1766 SMAD2 ROCK1 ARHA RHO PMC6820534__F6 Supposed mechanism CDC42 GRPR FLNB FLNA CD47 PMC3361678__F1 Many host factors are involved at each step of the HCV life cycle, which starts with virus binding to its specific receptors (CD81, CLDN1, OCLN, and SR-BI) GBF1 OSBP CD81 DGAT1 VAPB EPHA2 VAPA EGFR APOE PMC3158628__F1 Unlinking of the Golgi ribbon during G2 inhibits the recruitment and activation of Aur-A at the centrosome trough a novel mechanism AJUBA PLK1 CDC25B PMC6316730__F4 KEGG pathway analysis of the cell cycle in GNP-treated cells STAG2 DBF4 CDC20 PCNA CDC6 STAG1 SMAD2 APC SMAD4 MYT1 SKP2 CDK7 E2F4 CDC45 CDK2 MDM2 PMC11119800__F2 OGT is required for the development of infectious liver diseases OGA OGT MTOR PMC11119800__F1 Involvement of OGT in hepatic cellular stress RIPK3 OGT MLKL ULK1 ELF2 MTOR EIF2A PMC11119800__F4 OGT has dual effects on liver fibrosis TFF2 OGT PMC7076893__F8 Critical pathways of the potential Alpha-glucosidase inhibitors from RS INSR PDPK1 RXRA INS PMC4084917__F7 Fatostatin Displays High Anti-Tumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling HMGCS1 HMGCR FASN LDLR MVD MVK PMC11119800__F3 OGT contributes to the progression of NAFLD OGT SIRT3 FAS FOXO1 FABP1 AIMP2 XBP1 SIRT1 PARP1 PMC9065265__F5 SLC7A11, a Potential Therapeutic Target Through Induced Ferroptosis in Colon Adenocarcinoma CD44 SLC3A2 SLC3A1 GPX4 GCLM GCLC SLC1A2 PMC11119800__F5 Biological function of OGT in HCC RANBP2 RIPK3 OGT MMP14 KAT5 AGER FOXA2 MMP9 MTOR RUNX2 CTNNB1 EIF4E PMC8827490__F1 Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens CRP C6 FH C7 MASP2 HEL-S-62p C2 C9 C4B_2 CR1 PMC4473797__F6 E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses TLR3 IRF3 IRF7 PMC4473797__F4 E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses TLR3 TLR4 MAL IRAK1 IRF3 TRAF3 TRAF6 TNF PMC7019684__F2 mTORC1 is activated by amino acids, such as leucine, HMB, and arginine FOXO1 ULK1 BNIP3 CASTOR1 EIF4E PMC7827494__F2 Notch crosstalk with other signaling pathways CDH2 HEY2 ECD LRP5 SMAD4 SHH LRP6 SMO HIF1A ARHA HES1 CTNNB1 PMC12040673__F6 Structural features and signaling pathway of RLRs STAT1 TIRAP TLR3 TLR4 IRF3 TRAF6 TNF MYD88 PMC12040673__F5 Inhibitory effects of supersulfides on the TLR signaling pathway NLRP3 TLR4 PMC12075957__F11 Canagliflozin alleviates progestin resistance by suppressing RARB/CRABP2 signaling in THRB knockout endometrial cancer cells BAX RARB CRABP2 RXRA NR1A2 PMC7321795__F3 Mechanisms of Selected circRNAs in CAD(A) circNfix leads to the degradation of Beta-catenin and inhibits cell proliferation through combining with miR-214 DNMT3B PINK1 GSK3B MEIS1 YBX1 CCNA2 CCNB1 ACR CTNNB1 PMC8998738__F8 Dual Anti-Inflammatory and Anti-Proliferative 3-Styrylchromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling CDC2 C6 BAX HMGB1 PMC3588051__F3 Ingenuity Pathway analysis of lung cancer and/or COPD versus controls revealed NFKB as a major foundation CRP HEL-S-22 EZR UBC HEL-S-130P HEL57 HEL-S-69p HEL-S-26 HEL-75 HEL-S-15 PMC3057579__F9 Hypothetical diaphragm of HS7 induced apoptosis and inhibition of Wnt/Beta-catenin signaling pathway in HT-29 colon cancer cells MMP7 BAX TEF CTNNB1 PMC5591886__F2 A crosstalk between endoplasmic reticulum (ER) stress and p38 mitogen-activated protein kinase (p38 MAPK) pathway in the context of pemphigus FURIN PMC8922473__F6 Retinoic Acid-Induced 2 (RAI2) Is a Novel Antagonist of Wnt/Beta-Catenin Signaling Pathway and Potential Biomarker of Chemosensitivity in Colorectal Cancer CTBP2 APC GSK3B LRP5 LRP6 CTNNB1 PMC4684888__F1 Interactions of oxidative stress, inflammation, insulin resistance, and hyperandrogenemia are described briefly in the figure, which are all involved in polycystic ovary syndrome physiopathology IGF1 SHBG INSR IL16 IGFBP1 PMC6861325__F4 Pathway analysis network of 131 preliminary potential genes PRLR EGF HGF LEP OXTR AVPR2 AKT3 SEMA3E CTSG TGFBR2 MYLK SLIT2 MME CCL21 IF2D BMP4 TACR1 NR1A2 GHR PDGFD PTGER3 VAV3 SEMA3G LEPR NGFR KIT AREG IGF2 NR3C1 FGF2 CALCR CCL14 ACACB S1PR1 PTGDR FGF7 NRG1 TSLP CMA1 CCL28 SEMA3A SEMA3D IGF1 PDGFRA ADRB2 EDNRB FGFR3 BDNF PMC8472484__F9 Ailanthoidol, a Neolignan, Suppresses TGFB1-Induced HepG2 Hepatoblastoma Cell Progression CDH2 MMP2 PMC7057934__F7 Schematic model of the underlying mechanisms of miR-126-3p-mediated suppression of proliferation, migration and invasion through the PI3K/PDK1/AKT pathway BAX BAD PLCG1 PAK1 ROCK1 GSK3B CCND1 PMC5789953__F1 Lipoic acid synthesis and scavenging in E LIPA LIPI LIPM PMC9649744__F4 New insights into the characteristics of DRAK2 and its role in apoptosis: From molecular mechanisms to clinically applied potential SMAD2 SMAD4 PMC7306856__F1 Autophagy pathway NBR1 TBK1 ATG16L1 WIPI2 ULK1 ATG14 MTOR STX17 ATG101 ATG3 ATG12 PPT1 ATG5 PMC9063434__F2 Metallodrugs: an approach against invasion and metastasis in cancer treatment FAS ZEB2 ME1 PMC8335161__F2 Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer C6 NBR1 C7 HEL-S-62p ULK1 ATG14 TTI1 MTOR DEPTOR ATG10 MLST8 ATG3 ATG12 C9 BCL2 ATG5 PMC8335161__F1 Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer HTRA2 BAX CASP9 ATR BAD FAS MCL1 SIRT2 TUG1 CASP3 ATM BMF HRK FADD PMC8335161__F3 Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer EGF TNC EGFR GSK3B LRP5 LRP6 EZH2 PTEN LEF1 SOX4 CTNNB1 PMC6361976__F1 The largest gene regulatory subnetworks in yeast CIRSR DKFZp686O2396 PMC3775241__F3 Regulation of hepatic hepcidin induction at the cellular level BMPR2 STAT3 TFR2 SMAD6 SMAD4 HFE IL6 BMPER TMPRSS6 HFE2 PMC5382783__F5 Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics CYP2A6 LOX PTGES CS PMC2919646__F2 Cystic Kidney Disease: the Role of Wnt Signaling BBS10 BBS12 APC GSK3B BBS1 ARHA RAC1 CTNNB1 VHL TSC2 TSC1 OFD1 BBS4 TEF NPHP3 UNK DAAM1 PMC9482125__F11 CyR61 expression and release by 3-mercaptopyruvate sulfurtransferase in colon cancer cells SP1 SHH ATF1 ARHA CCND1 PMC7298716__F9 DINO regulation in HPV-positive cervical cancer cells CDKN1A ATM MDM2 PMC1934518__F2 Ligands identified for EpCAM and possible functions related to them EPCAM CD9 PMC6361976__F2 The pertinent features of the phosphocholine pathways CDS1 PC PSD2 PMC4157394__F13 Apoptosis pathways affected by rocaglamides BAX FADD PMC10816399__F2 IL-6R interaction with gp130 for Stat3-mediated inflammatory target gene expression SOCS1 STAT3 IGF1 SOCS3 PMC4157394__F12 Inhibition of protein synthesis by rocaglamides RHEB TSC2 TSC1 PTEN GRB2 MTOR EIF4E PMC4085993__F4 Iron Homeostasis in Peripheral Nervous System, Still a Black Box? NRG1 MPZ MBP PMC3408425__F9 Systems-level regulation of metabolic genes by Met TFs ACO2 GUK1 CDS1 MDH2 HEL-S-26 GPX1 POT1 PMC6055003__F1 Notch pathway is regulated by short-range cell–cell signaling DLL4 HIF1A NOTCH2 NOTCH3 DLL3 RBPJ NOTCH1 PMC8549964__F3 Local delivery of FTY720 induces neutrophil activation through chemokine signaling in an oronasal fistula model CXCR3 CSF1 PIK3R5 NCF2 CCR5 PIK3CD JAK3 CCR2 CCL2 IL11RA CSF3R CSF2RB INHBA ACVR1B ROCK1 CCL7 ITK SRC TNFRSF14 ROCK2 ARRB2 STAT2 NCF4 VAV1 ARHA RAC1 TNFSF14 IKBKB PS1TP5BP1 PF4 PMC5659022__F2 Proposed scheme for the role of BMSCs in modulation of p53-miRNA interaction in association with stroma-induced drug resistance in MM BAX CDKN1A IL6 PMC8549964__F2 Local delivery of FTY720 induces neutrophil activation through chemokine signaling in an oronasal fistula model S1PR1 S1PR3 ROCK2 PIK3R5 S1PR2 ROCK1 PIK3CD BCL2 PLCB2 S1PR5 PRKCB S1PR4 PMC2810618__F8 Signaling network model for heart valve development and remodeling ERBB3 HBEGF EGFR ERBB2 HAS2 NFATC1 PMC4006928__F1 DNA Damage Response, Redox Status and Hematopoiesis BMI1 ATM PTEN PMC3149098__F6 GProX Pathway Analysis of the Cellular Response to EGF Stimulation MCAM MAFK BTC PIR PMC8164969__F2 Molecular pathways governing hepcidin regulation in the liver ERFE STAT3 BMP6 TFR2 KEAP1 BMP2 HAMP TERT HFE TMPRSS6 HFE2 PMC8164969__F1 Iron regulatory cycle ERFE TFR2 HAMP HFE TMPRSS6 HFE2 PMC5455213__F1 Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature NONO CD47 PMC5360051__F5 Proposed deregulation of type I IFN signalling pathway by AFB1 STAT2 JAK1 TYK2 PMC5453167__F2 Protein-protein interaction network of the DEGs PSMD4 MORC1 MCHR2 JUN PTPN11 EFCAB6 PMC8393694__F2 Targeting of Native Proteins to the Endoplasmic Reticulum-Associated Degradation (ERAD) Pathway: An Expanding Repertoire of Regulated Substrates HMGCR ACAT2 APOB PMC4005604__F2 Targeting the Mevalonate Cascade as a New Therapeutic Approach in Heart Disease, Cancer and Pulmonary Disease CDC42 VIT IPP RHO MTOR PMC7405053__F1 An overview of PG biosynthesis, receptors, and downstream signalling pathways COX1 AKR1B1 PMC7405053__F3 Possible mechanisms for PGE2 modulation of immune cell functions in COVID‐19 TMPRSS2 STAT3 IF2B1 STAT2 IRF3 IRF7 TNF CCL2 MYD88 IFNG STAT1 NLRP3 COX2 ACE2 IL1B PMC5206770__F10 Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice RHEB TSC2 RICTOR TSC1 PTEN RHO PDK2 MTOR PMC2832675__F1 Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement BAX CASP8 CASP3 BCL2 TNF FADD PMC4259944__F1 Mutant epidermal growth factor receptor endocytic trafficking EGF EGFR ERBB2 SRC PMC7173364__F6 Apoptotic Cell Death Induced by Fractions F2 and F3 of Vitex Rotundifolia in T-47D Cell Line BAX F2 F3 PMC9164338__F5 Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses HMOX1 GCLM PIK3C2A NQO2 HEL-75 PMC5584748__F3 Chronic obstructive pulmonary disease candidate gene prioritization based on metabolic networks and functional information CYP1A2 CYP2C18 CYP3A7 CYP2A6 CYP2B6 DHRS9 LRAT CYP2C9 CYP2C8 CYP1A1 CYP3A4 PMC4675101__F8 Molecular pathway underlying interaction of Zn deficiency and miR-31 overexpression in promoting esophageal preneoplasia SP1 STK40 S100A8 S100A9 PMC533862__F1 Heuristic model showing the tyrosine phosphorylation signaling pathways in sperm cell involved in capacitation C2 PMC3897565__F1 Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells IL10 PLCG1 IL2 PMC9164338__F7 Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses STAT1 FAS TNFSF6 IRF3 TYK2 PMC5289288__F1 Identification of KRT16 as a Target of an Autoantibody Response in Complex Regional Pain Syndrome KRT10 CREB3 KRT14 ANXA2 HEL57 SERPINA1 ENTPD1 HEL-S-30 TUBB SERPINB5 GFAP HSPD1 NFYA EEF1A1 F9 HEL-S-87p PS1TP5BP1 TPSAB1 PMC6102400__F1 Interactions of Lactobacillus rhamnosus GG or LRY (green) with Helicobacter pylori (red) and damaged epithelial cells at the gastric mucosal surface EGF MUC6 COX1 TNF PMC9336529__F2 Clinical potential of the Hippo-YAP pathway in bladder cancer LATS1 MINDY1 PMC5528331__F4 MAPK signalling pathway with unstable and stable (copy number and expression) genes represented RAF1 MAP3K13 MAP3K12 PRKCZ MAPK9 MAP3K11 ATF2 PPP3CA MYC TRAF6 PPP3CC FLNA MAPK3 MAPK14 HSPB2-C11orf52 NF1 HEL-S-11 MAPK12 GCK MAPK1 RASGRP4 CASP9 TAOK2 CRKL MAPKAPK2 RASGRF2 DUSP4 TNF FOS MAP3K1 SOS2 MAPK7 MAP3K7 MAPK10 GRB2 HEL-S-31 MAX CDC42 DUSP10 EGF FAS TGFB1 MAPK13 AKT3 PPP3R1 BRAF MAP3K14 IKBKG MEF2C PRKCH TGFBR2 FGF7A CASP6 MAP2K4 ATF4 DUSP7 UNK MAP4K3 JUN CASP2 MAP4K1 CD14 PPP3R2 KRAS MOS NFKB1 IKBKB CASP3 HEL-S-102 DDIT3 NTRK1 TMEM37 RPS6KA3 MAP2K2 NLK TRAF2 PMC9336529__F1 Clinical potential of the Hippo-YAP pathway in bladder cancer LATS1 MOB1A MOBKL1A LATS2 NF2 PMC3285584__F9 Loss of Tgif Function Causes Holoprosencephaly by Disrupting the Shh Signaling Pathway SMAD2 SHH NODAL FGF8 FOXG1 GLI3 PMC9336529__F3 Clinical potential of the Hippo-YAP pathway in bladder cancer CDC42 MINDY1 RHOB ARHA PMC3713848__F9 Proposed model for the integration of primary afferent, mast cell and sympathetic systems in supporting CRPS-related nociception NGF RAMP1 IL6 IL1B PMC4401766__F1 Simulation Predicts IGFBP2-HIF1A Interaction Drives Glioblastoma Growth IGFBP2 HIF1A VHL PMC4828118__F3 Drugs interfering with breast cancer (BC)- and obesity-related pathways TSC2 TSC1 HIF1A MTOR PMC5544725__F7 Role of 1,25(OH)2D3 in myofibroblast differentiation and extracellular matrix deposition in TGFB1-induced nasal polyp-derived fibroblasts and nasal ex vivo organ culture NR1i1 SMAD2 PMC2840262__F2 Autophagy and the Ubiquitin-Proteasome System in Cardiac Dysfunction NBR1 BAG3 BAG1 HDAC6 PMC7730964__F1A Inhibition of the Wnt Signalling Pathway: An Avenue to Control Breast Cancer Aggressiveness BCL9 PYGO2 APC GSK3B LRP5 LRP6 CTNNB1 PMC4934886__F4 Aortic valve stenosis–related biological processes BGLAP ALPL CD133 CCL5 LPA CCL23 MME HSPD1 SOX9 CCR7 MMP2 KDR NOTCH1 CCR1 MMP7 NOS2 TNFRSF12A CST7 ITGB7 L1CAM APOE AGTR1 CTSK NRARP TNF CERCAM FURIN HBEGF TRHDE TNFSF11 WNT3 GSC VCAM1 BDKRB1 PLEK2 CXCL12 HSPG2 TGFB1 CXCL1 IL2RA KCNN4 COL3A1 TGFBR2 NR1B3 GPC5 ADAM17 ADAM12 FXYD1 IL10 CADM2 CD248 ANGPTL1 PECAM1 SFRP1 SPP1 CHI3L1 AGTR2 PKHD1L1 ELOF1 IL2RB RUNX1 MGP BMP2 STAT4 PLEKHG1 ApoL6 PPARG CXCR3 CCL18 CADM1 HLA-DOA JAK3 MGST1 CTSS CTSZ SMPD1 CTSG FGF8 AHSG SAMD1 PLOD2 DCN MSX2 TNFAIP6 TNFRSF11A HEL-S-2 TIMP3 APOC1 FOSB ROR2 ANGPTL2 SERPINA1 GPR158 VEGFA CXCL14 FOS RUNX3 VCAN ACAN ENG LOXL2 CCL19 HMGCR APOB LRP1B COL12A1 PLTP BDKRB2 TNC TIMP1 HEY2 TIMP4 CADM3 CTHRC1 IBSP COL10A1 RUNX2 CTNNB1 RARA ZBP1 BMP4 GREM1 LDLR DKK2 AOX1 CEACAM1 SELE CXCL16 SMAD6 MMP9 DKK3 PLCE1 HIF3A HEL-S-130P TNFRSF11B WIF1 PMC8268239__F5 Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications AIMP2 IL6 DDC PMC8837098__F1 mTOR Signaling Components in Tumor Mechanobiology RHEB TSC2 TSC1 PTEN PMC11963613__F4 This schematic illustrates the role of Wnt/Beta-catenin signaling in tumor immune evasion and potential therapeutic strategies targeting this pathway TIGIT APC BTLA CD47 LAG3 CTNNB1 PMC11963613__F3 This figure illustrates the toxicity and management strategies associated with Wnt-directed therapies in cancer treatment APC IMPACT CTNNB1 PMC8268239__F1 Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications ID2 KYNU KMO AFMID ID1 PMC11963613__F1 This figure illustrates the role of the APC gene within the Wnt signaling pathway and its significance as a cancer biomarker APC LRP5 LRP6 CTNNB1 PMC3256849__F6 A model for Kv1.3-mediated signaling pathway in human T effector memory cell differentiation CDC2 SMAD2 SMAD4 CCNB1 PMC6165247__F1 Consequences of endoplasmic reticulum stress response pathway RHEB ATF4 MTOR XBP1 PMC6288292__F2 Effect of different preconditioning stimuli in the MSCs response HGF TGFA GDNF MSC CXCR4 IL1B PMC3662029__F4 Mnk Kinases in Cytokine Signaling and Regulation of Cytokine Responses IFNG ISG15 EIF4E PMC8197724__F1 P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases BAX BOK APAF1 FADD PMC6544365__F1 PI3K/Akt signal pathway is crucial to SDF1/CXCR-mediated homing of endothelial progenitor cells (EPCs) after myocardiac infarction VCAM1 CXCR4 PMC10088895__F1 PD-1/PD-L1 pathway plays a role in immunosuppression ZAP70 LAT APC PTEN PMC4498277__F2 Sclerostin actions LRP4 LRP5 LRP6 PTH PMC3137161__F1 Roles of shati on dopamine uptake – the relationship shati and TNFA SRI TNF PMC5644649__F3 Signaling model of Nef-mediated (A) apoptosis/anti-apoptosis, (B) down-regulation of expression of MHC class I molecules, and (C) down-regulation of the expression of CD4 molecules CDC42 SYK BAD ARF1 ARF6 PACS1 LCK PMC4599194__F1 Schematic model of MIF pathways in breast cancer cells (BCC) CD74 MIF CXCR4 PMC8231548__F3 Perivascular Adipose Tissue-Derived Adiponectin in Vascular Homeostasis APPL1 RS1 INS IRS1 PMC9010822__F1 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances SUFU SHH MYC PMC11615816__F6 PGRN Inhibits B‐cell Activation and IgE Production through the PGRN‐IFITM3‐STAT1 Signaling Pathway IFITM2 CD19 GRN PMC9010822__F6 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances CD44 TCTN3 SOX2 SHH BCL2 SFN SMO MTOR ABCG2 PMC9010822__F3 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances PIK3CA TGFBI MAL PMC9010822__F2 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances STH SHH SMO PMC9010822__F5 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances DISP1 SHH SMO PMC9010822__F4 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances STK11 TUSC3 HHIP TCTN3 KRAS TMEM107 HCFC1R1 PTCH2 SUFU PTCH1 DISP1 SHH SMO GATA6 LZTFL1 PMC2955614__F5 Novel molecular regulation of Wnt/Beta-catenin pathway KLF4 STAT3 SIAH1 EGFR APC GSK3B CTNNB1 HDAC3 GBX2 HDAC1 VENTX FOXC1 ZEB2 TNIK PMC8476931__F5 Chromosome-level genome assembly of Gynostemma pentaphyllum provides insights into gypenoside biosynthesis MYB ERF IPP GPS1 PMC7838037__F5 NF-Kß mediated signaling pathway leading to mucus hypersecretion EGF SP1 EGFR MUC2 MARCKS PMC7838037__F4 MAPK mediated signaling pathway induced by interleukins leading to mucus hypersecretion MUC5AC IL16 MUC5B MUC2 MARCKS MUC1 GRB2 MUC4 MYD88 PMC4488716__F1 Signaling pathways of the endoplasmic reticulum (ER) stress response ATF4 EIF2A XBP1 PMC4517435__F1 Core components of the insulin signaling pathway MAPK1 RAF1 SHC1 SOS1 GYS2 AKT3 PTPN1 PTEN SHC2 MAP2 KRAS IRS1 MAPK3 HRAS PDPK1 GYS1 SOS2 NRAS MAP2K1 GRB2 PMC8832963__F3 Emerging role of long noncoding RNA RMRP in cancer development and targeted therapy CCND2 ANXA2 MDM2 KRAS YAP1 SNRPA1 PMC9559463__F3 Long-Term Management of Advanced Basal Cell Carcinoma: Current Challenges and Future Perspectives SUFU PTCH1 SMO PMC9559463__F5 Long-Term Management of Advanced Basal Cell Carcinoma: Current Challenges and Future Perspectives IFNG SUFU APC PTCH1 SMO TNF LAG3 PMC7926472__F1 A general map of core metabolism C2 FES PMC3392647__F3 Metabolic regulation of epigenetics OGT SIRT1 SIRT6 PMC3875828__F1 Asp and aromatic amino acid biosynthetic pathways in plants ASPG CBL PPY PMC7350257__F2 PI3K-AKT-mTOR and RAS/MAPK pathway crosstalk can contribute to mTORC1 and AKT inhibitor resistance BAD SGK1 ULK1 GSK3B ERBB2 MDM2 IRS1 PMC7019732__F6 FIPV nsp5-mediated inhibition of the type I IFN signaling pathway during FIPV infection TBK1 MAVS TRAF5 IRF3 TRAF6 TRAF2 PMC7350257__F4 PI3K-AKT-mTOR and WNT signaling crosstalk HEL-S-133P EGFR APC GSK3B LRP5 TTI1 LRP6 PTEN MYC DEPTOR CTNNB1 LATS1 TSC2 LATS2 SOX4 CDK4 PMC7350257__F3 PI3K-AKT-mTOR and AR signaling crosstalk facilitates resistance to androgen/AR and AKT-directed monotherapy FKBP5 CYP17A1 KLK3 PMC9559463__F1 Long-Term Management of Advanced Basal Cell Carcinoma: Current Challenges and Future Perspectives SUFU PTCH1 SMO PMC11302957__F1 Core components of the Hippo pathway in mammals LATS1 AXL AREG YAP1 PMC11302957__F3 Crosstalk of Hippo signal pathway with other signaling pathways to regulate YAP1 LATS1 HGF FZD2 EGFR SIX4 PDCD10 RDH5 MTOR YAP1 PMC4868686__F6 VE-cadherin cleavage by ovarian cancer microparticles induces Beta-catenin phosphorylation in endothelial cells MMP7 PAK1 APC LRP5 MMP2 MMP9 CCND1 LEF1 RAC1 CTNNB1 PMC6998390__F8 BACE2‐regulated pathway in glioma cells SMAD2 BACE2 PMC4521049__F8 New working model TLR4 EBI3 VCAM1 PMC428488__F1 Outline of the Taxol biosynthetic pathway IPP C9 PMC2992289__F5 KLA increases mRNA expression of genes involved in sphingolipid biosynthesis CERS3 ASAH2 CERK SPHK2 CERS1 CERS2 SMPD2 CERS6 PMC3073335__F2 RNA helicases of the RIG-I-like receptor (RLR) family play a crucial role in the innate antiviral response STAT2 IRF9 IRF3 IRF7 PMC10846991__F3 Interleukin-6 (IL-6) signaling pathway STAT3 SHC2 MTOR PMC7367493__F2 RNA sensing and regulatory roles of NLRs MAVS ATG16L1 NLRP14 TUFM NLRP9 IRF3 NLRP12 NLRX1 GSDMD RNF125 ATG12 NLRP6 TRIM25 NLRP3 DHX15 NOD2 ATG5 IL1B PMC7367493__F1 TLR and RLR signaling pathways TBK1 MAVS IRAK1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TRIM25 TLR3 IFNAR2 IFNAR1 TLR8 RIPK1 TLR7 JAK1 TRIM65 ZCCHC3 PMC10846991__F4 Overall signaling pathways between podocytes and glomerular endothelial cells (GECs) CXCL12 ANGPT1 VEGFA ANGPT2 CXCR4 PMC11799769__F4 Correlation network diagram between renal‐secreted proteins and proteins on the most significantly altered KEGG pathways in skeletal muscle HEL-S-134P LAMA5 NDUFB6 DAG1 LIF CYCS NDUFV2 ORM1 NDUFA7 COA7 LAMB1 SPP1 SUCLG1 LAMB2 MAPK12 MDH2 HP NDUFA5 LHPP PMC5635761__F1 Possible Nucleic acid sensors participation in HBV pattern sensing in the life cycle of HBV CGAS MAVS TLR3 TLR9 TLR8 DDX41 AIM2 IFI16 IRF3 IRF7 TLR7 MYD88 PMC7790818__F3 Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore BAX FAS BCL2 PMC7047768__F1 Summary of transcriptional regulation of senescence in MSCs CDK6 H2AX MSC CDK2 CDK4 PMC11232665__F4 Metformin likely acts on intervertebral disc degeneration through SIRT-related signalling pathways SIRT3 PINK1 SIRT1 PMC3789782__F1 Herpes Simplex Virus Type 1 Single Strand DNA Binding Protein and Helicase/Primase Complex Disable Cellular ATR Signaling TOPBP1 ATR ATRIP RAD17 PMC11232665__F3 Mechanism of metformin in intervertebral disc degeneration HMGB1 CGAS SNAP29 MSC PMC6438438__F8 Diagram demonstrating the unfolded protein response pathway and downstream chaperone proteins ATF4 EIF2A XBP1 PMC11232665__F2 Intervertebral disc degeneration ATF3 SIRT3 MMP3 MTOR IRS1 PMC6711852__F2 Physiological and pathological hypertrophy ADRBK1 CITED4 BAX EYA2 FOXO3A PTEN MTOR GATA4 PMC10189743__F5 Involvement of ITGA and ITGB receptors in ‘focal adhesion’ and ‘ECM receptor interaction’ from the Kyoto Encyclopaedia of Genes and Genomes pathway database CDC42 CRK BAD VASP HEL-S-28 PTEN ARHA SHE PMC6181582__F3 Protein based pathway mapping of the patient response in the serum to antibiotic treatment POR APOA2 TH HPSE SPIC ND1 APOH APOE HRG APOB PLTP PROC PMC3163839__F3 Progression of amyloidogenesis in parahippocampal region and hippocampal formation of mediotemporal lobe CA3 HEL-S-11 SIRT1 PMC3163839__F2 Sirt1 activity as it relates to AD etiology RARB FOXO3A ADAM10 SIRT1 PMC3697894__F1 Notch signaling pathway EGF PSENEN DLL4 DLL3 PMC8353789__F1 Perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed? ATG101 TFEB ATG14 MTOR HDAC6 PMC12170998__F2 Development of Traditional Chinese Medicine in combination with EGFR Inhibitors against Cancer EGFR PTEN MTOR PMC12170998__F3 Molecular pathways related to EGFR-TKI resistance AXL EGFR PTEN IGF1R MTOR PMC7074480__F1 Mechanism of action of the nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome GSDMD NLRP3 IL16 PMC8631411__F2 Molecular mechanism and therapeutic targeting of necrosis, apoptosis, pyroptosis, and autophagy in cardiovascular disease GSDMD NLRP3 AIM2 PMC8631411__F1 Molecular mechanism and therapeutic targeting of necrosis, apoptosis, pyroptosis, and autophagy in cardiovascular disease TRADD ATG12 C2 UVRAG AMBRA1 TRAF2 FADD PMC4037387__F2 JAK/STAT pathway dysregulation in tumors: A Drosophila perspective PRC1 CSK SCRIB PMC3203219__F1 Costimulatory pathways relevant in transplantation CD40 ICOS TNLG8A APC BTLA PMC4180975__F8 Model depicting CtsZ regulation of the protumorigenic functions of TAMs and cancer cells CTSZ SRC PMC4060956__F1 Abnormal Ca2+signaling in SNc DA neurons may cause mitochondrial oxidant stress, proteostasis deficits and eventual cell death PINK1 LRRK2 NACA PMC10376991__F8 An Autophagy-Associated MITF–GAS5–miR-23 Loop Attenuates Vascular Oxidative and Inflammatory Damage in Sepsis KEAP1 DGKE PMC3359066__F5 Identification of Functional Differences in Metabolic Networks Using Comparative Genomics and Constraint-Based Models ME2 MAL PMC7465596__F1 Signaling and gene regulation of the canonical cell autonomous unfolded protein response (UPR) ATF4 EIF2A XBP1 PMC6682706__F1 Natural plant compounds and epithelial-to-mesenchymal transition CDH2 STAT3 TH SMAD1 TGFBI TGFB1 HGF DKFZp781O1323 SMAD2 GSK3B BMP7 HEL-S-28 MTOR ARHA NEDD9 CTNNB1 LPA MMP3 PMC12142240__F7 Proposed pathway by which reduced SPDL1 expression leads to epithelial-mesenchymal transition and promotes cell migration and invasion in colorectal cancer EGF EGFR SPDL1 PMC11562816__F1 Low-frequency variants in genes involved in glutamic acid metabolism and Gamma-glutamyl cycle and risk of coronary artery disease in type 2 diabetes GOT2 PIG59 ALDH18A1 GLS GCLM GCLC C7orf24 GAD1 DPEP2 GAD2 OPLAH HEL-S-64p PMC4160336__F4 Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host CDC42 NOD1 RHO PMC4647833__F3 Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing MYLK2 PLN FAS FXN RAF1 PRKAG2 MYOZ2 ACTN2 MRPL3 SLC25A4 MYL3 CASQ2 tmp_locus_29 CSRP3 TPM3 MYL2 MYPN TTN KLF10 MYBPC3 RYR2 SRI ANKRD1 TNNC1 FOXK1 GLA FLJ10842 HEL114 LAMP2 MYOM1 JPH2 MYL12A ADRB2 TPMT PMC10844198__F2 Putative NFKB signaling pathway data mined from Euprymna scolopes reference transcriptome and genome TRAF4 TBK1 MAP3K7IP1 TAB3 NLRC3 TRAF3 TRAF6 TRAF2 IRAK4 MYD88 PMC4041713__F4 Differential Expression of MicroRNA and Predicted Targets in Pulmonary Sarcoidosis PRICKLE2 PLCB4 SIAH1 NFATC2 APC FZD7 SMAD4 ARHA PSEN1 CTNNB1 CXXC4 BTRC VANGL1 PPP2R2A PRKCA PRKX EP300 NLK PMC4041713__F2 Differential Expression of MicroRNA and Predicted Targets in Pulmonary Sarcoidosis BMPR2 THBS1 SP1 BMPR1A SMAD2 SMAD4 RBL2 E2F5 GDF6 MAPK3 TGFBR2 ZFYVE16 IFNG SMURF1 LEFTY2 PMC4044302__F1 Sites of thyroid hormone regulation of metabolism STAT3 FAS TRH FOXO3A MAFA CYP7A1 LDLR UCP1 PMC4290816__F1 Primary points at which PUFA-based supplements enter the PUFA biosynthetic pathway ELOVL2 GLA FADS2 PMC3641131__F6 Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains Beta-Cell Phenotype in Human Islets TSC2 TSC1 IGF1 MPC1 MTOR MPC2 IRS1 CTNNB1 PMC7069221__F1 Estrogen biosynthesis and signaling pathways CYP1B1 CYP1A1 PMC7990371__F3 Directly and indirectly anti-cancer pathways of APN STAT3 TSC2 GSK3A USP2 MTOR CCND1 WIF1 CTNNB1 PMC9314982__F3 Coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy TF VLDLR PMC7069588__F4 Schematic diagram CDH2 PMC5913878__F2 Emerging roles of epithelial-mesenchymal transition in hematological malignancies TWIST2 BCL6 TWIST1 CTNNB1 PMC152295__F1 The PI metabolic pathway and wortmannin sensitivity IPP PI3 PTEN PMC8256442__F4 Signaling Pathways That Regulate the Crustacean Molting Gland RHEB EGF INSR EGFR MTOR PMC8038686__F3 Tissue fragmentation and mechanical manipulation disrupt ovarian Hippo signaling pathway and promote follicle growth LATS1 LATS2 PMC120783__F7 GPI biosynthetic pathways in T LPL GAL HEL-S-5 PLG PMC4334750__F6 Theoretical model for metabolism of alcohol in the brain GRIP2 GLUD1 GRINA GPT2 PMC3523810__F7 Possible inflammatory signaling pathway that results from the functional associations of the identified inflammation-related proteins (marked with an underline), which is regulated by acupuncture in asthma S100A8 RHO S100A9 PMC9170579__F6 Long noncoding RNAs (lncRNAs) in human lymphomas SUZ12 EED EZH2 ERG PMC8783605__F3 Peripheral nerve stimulation and immunity: the expanding opportunities for providing mechanistic insight and therapeutic intervention NTS CRH TNF IL1B PMC9600404__F3 Newest Therapies for Cholangiocarcinoma: An Updated Overview of Approved Treatments with Transplant Oncology Vision PTEN MTOR FGFR2 PMC6030085__F7 SOX17-mediated disruption of Wnt/beta-catenin signaling SOX17 GSK3B CTNNB1 PMC3346964__F1 Four major molecular pathways activated by tyrosine kinase receptor B (TrkB) and IGF-1 receptor (IGF-1R) RAF1 IGF1 IGF1R GRB2 MTOR BDNF PMC5071175__F4 Planar cell polarity (PCP) proteins and spermatogenesis CDC42 ROR2 ARHA RAC1 DAAM1 PMC9189173__F7 Study on plasma amino acids and piperonamide as potential diagnostic biomarkers of non-small cell lung cancer PSAT1 HEL-S-51e PMC3918721__F1 TGFB signaling and MMPs interplay LTB RHO SHE PMC4260876__F7 Drought Tolerance Conferred to Sugarcane by Association with Gluconacetobacter diazotrophicus: A Transcriptomic View of Hormone Pathways MYB ERF EBF2 PMC6834079__F1 The Hedgehog signaling pathway and depiction of key regulatory interfaces HHIP KIF7 BOC SUFU PTCH1 SMO PMC7314846__F3 N6-methyladenosine (m6A) methylation in ischemia–reperfusion injury STAT3 CDKN1A LIF GSK3B CCND1 FADD PMC11656820__F2 Expression of Tim-3 on various immune cells and the functional alteration of these cells in sepsis-induced immunosuppression CD44 HMGB1 IL10 FOXP3 TNF PMC3124359__F1 Estrogenic effects on gp130 signaling STAT3 OSM LIF BDNF PMC11656820__F1 Tim-3 signaling pathway ZAP70 HMGB1 FYN LCK PMC11656820__F3 Function of dysregulated Tim-3 pathway in sepsis-induced immunosuppression IL15 TH IL10 IL4 FOXP3 PMC3936888__F7 Scheme for illustrating the effect of Naproxen on the regulation of cell cycle and apoptosis mediated through the inhibition of the PI3-K signaling pathway BAX BCL2 MTOR CDK4 PMC3033145__F2 Anticoagulant properties of endothelial cells TF TFPI APC PC PMC9541200__F2 NAD+ deficiency in human congenital malformations and miscarriage: A new model of pleiotropy ART3 ART4 PARP6 SIRT7 NAPRT PARP4 AFMID SIRT2 NMRK2 SIRT3 PNP HAAO PARP2 SIRT6 NMNAT3 HEL-S-90n KYNU NMNAT1 SIRT4 KMO SIRT5 NAMPT NMNAT2 BST1 PARP1 NMRK1 TDO2 IDO1 TRPT1 PARP3 NADSYN1 SIRT1 PMC4568949__F5 Non-invasive prognostic protein biomarker signatures associated with colorectal cancer HMFT1766 CADM1 F5 CFH MRC2 VTN PIGR HLA-A CP PMC7993397__F1 Integration of mechanical- and ECM-based tumor microenvironment-imposed signals LATS1 CD44 GRB7 LATS2 FYN AMOT PIEZO2 HEL-S-28 ARHA NF2 PMC3128083__F9 RIG-I Mediates Innate Immune Response in Mouse Neurons Following Japanese Encephalitis Virus Infection RIGI TRAF6 TRAF2 FADD PMC9170579__F5 Long noncoding RNAs (lncRNAs) in human lymphomas CDK6 APC GSK3B BRAF CDK2 MTOR CDK4 CTNNB1 FADD PMC4687703__F2 Local inhibition of miR‐24 in ECs would turn off apoptosis signalling pathway and improves reparative angiogenesis in post‐ischaemic conditions FAS PAK4 ESM1 SIRT1 PMC6266414__F3 Glutamine inter-tissue metabolic flux starting in skeletal muscle, liver, and gut continues in the immune cells GLS PDC PC SIRT1 HEL-75 PMC4619950__F3 Main molecular pathways activated for the production of inflammatory cytokines STAT3 STAT1 HGF EPO PMC6352376__F4 Functional analysis of significantly changed proteins (SCPs) SRSF7 SEC61A1 RAN SERPINF2 TGFBI COX7A1 ATP6V1A NDUFV2 COQ9 FAAH NDUFA10 ACADM NDUFS3 COXFA4 MME GC COL4A2 HCA112 LR8 NUDT12 UMOD PLG ATP1B1 HEL70 TWF1 HEL-S-78p TPP1 CDH16 ACSL1 COL6A1 LRPAP1 ABHD12 SLC25A11 OGDH ZNF183 FGA NDUFS1 NDUFB8 HEL113 UGGT1 SGPL1 NDUFA9 EDEM1 PSMA4 PZP ITGAV NDUFA11 RPS27 ACAT1 TUBA4A DHX15 MYH9 NDUFB7 HEL-S-108 NPLOC4 ACTN1 RPS6 SLC12A3 ACTG1 SERPINC1 Nbla10236 MYL6 ANXA3 NDUFC2 TMED9 ANXA6 S100A10 SFRS3 ACAD10 CHCHD3 LAMP2 FTH1 NDUFB10 ERAP1 HEL-S-130P ACTN4 MYL12A HEL-S-102 MYO7B COG7 SFRS5 TMEM65 MGAM NDUFA2 SPCS3 PRODH APOOL M6PR NDUFA5 PMC3319470__F1 Coenzyme Q10biosynthetic pathway and electron transport role in the mitochondrial respiratory chain ETFDH COQ7 ND1 PDSS1 ND4L COQ4 COQ3 ND4 COQ9 COQ6 COQ5 CYB ND5 ND6 ND3 ND2 PMC4619950__F4 Molecular pathways activated by inflammatory cytokines and growth factors and affected by MPN-associated mutations STAT3 MPL STAT1 EPO TPO JAK1 PMC9189280__F7 Curcumin Blocks High Glucose-Induced Podocyte Injury via RIPK3-Dependent Pathway RIPK3 MLKL RIPK1 PMC6058053__F3 Altered B cell receptor (BCR) and co-receptor signaling promotes increased autoreactivity within the naive B cell repertoire CD40 PTPN22 BCR WAS PMC7124275__F9 MAPK7-CEBPB signaling cascade negative regulation of mir128-3p under ischemia/hypoxic condition MAPK7 CREB1 IRS1 PMC6558065__F1 Proposed MFG-E8 signaling in radial glial cells (RGL) via AvB3/PI3K/Akt/mTOR pathway CCND2 MTOR PMC3037521__F2 Selective elimination of messenger RNA underlies the mitosis–meiosis switch in fission yeast TF TSC2 TSC1 PER1 PMC6156430__F2 Schematic diagram of the molecular mechanisms underlying K63‐linked polyubiquitination and cardiac hypertrophy TRADD TAB3 TRAF6 TRAF2 PMC7201019__F5 Pathways of viral sensing and TLR signaling, metabolism, cell motility and protein export are enriched in the NK RMtsig NAPA GUSB JUN CCS PTEN CTSS MTOR ARHA FOS UROD FLNA UROS ACAN IDUA TG ADK CLTA RELA PC LYN MDH2 HEL-S-87p RETSAT PMC3587307__F1 LEM2 is a negative regulator of ERK signaling during muscle differentiation EGF MTOR CTNNB1 PMC4890029__F9 MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells CCNB1 PMC4818947__F7 Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents ATR ATM MGMT PMC6765066__F13 HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases HMGB1 TLR4 TLR9 IL6 MMP9 CXCL8 SIRT1 IL1B MPO PMC9221142__F2 Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance? EGFR SRC HTT CTNNB1 PMC6765066__F12 HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases HMGB1 TLR4 MMP9 CXCL8 MPO PMC2629979__F1 Molecular Mechanisms in COPD pathogenesis and potential therapeutic targets TGFBI EGR1 TGFB1 KEAP1 PMC8586819__F2 T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective IFNG TIGIT CD244 CD160 TOX CTLA4 TNF PMC4495583__F3 Dendritic cell metabolism ECSIT TBK1 TLR1 MAVS NLRP3 TLR4 IRF3 IRF7 TRAF6 IL1B PMC12058309__F1 Biosynthesis, metabolism and signaling of SA SAG COCH NPRC PMC4495583__F2 Dendritic cell metabolism TBK1 HK2 XBP1 PMC5460804__F7 Schematic drawing that illustrates the likely signaling pathway by which laminin A2 at the basement membrane regulates Sertoli cell BTB dynamics in the seminiferous epithelium of rat testes RPS6 PMC4937469__F11 Surviving problems during chromosome replication DBF4 RAD18 RAD51 PCNA PMC8166896__F1 Molecular mechanism of necroptosis AURKA OGT TRADD MLKL OTULIN GSK3B TNF RIPK3 SHARPIN ZBP1 TLR3 MIB2 RIPK1 CDC37 PPM1B TRAF2 CYLD FADD PMC8130833__F1 Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma ATR ATM PMC6544733__F5 Bioenergetic metabolites differ significantly between the Boxers and Chihuahuas C6 HEL-S-62p C2 PMC3458056__F5 Molecular Characteristics and Metastasis Predictor Genes of Triple-Negative Breast Cancer: A Clinical Study of Triple-Negative Breast Carcinomas MAPK1 PRMT2 IGFBP5 RELA TERT IL6 CBX3 MYC TNF NFKBIB CSNK2B MAPK3 PMC3695482__F2 Focus on Histone variant H2AX: to be or not to be RAD50 MRE11A BRCA1 H2AX BRCA2 ATM PALB2 PMC11884491__F7 Schematic illustrates the antiproliferative effect of P PCNA SMAD2 PMC8000126__F7 TR-dependent regulation of genes in the Wnt signaling pathway, a representative pathway likely involved in the development of adult intestinal stem cells, as revealed by RNA-seq analysis SIAH1 APC SMAD4 RYK ARHA BAMBI RBX1 SOST INVS NOTUM CER1 SKP1 NLK DAAM1 PMC5446740__F5 Disease module predicted by GLADIATOR for hyperinsulinism LPL HLA-DQA2 SP1 ARPC3 PLK1 PSEN1 INS HLA-DQB1 NR2F1 RB1 HEL-S-99n LIPC CEBPA NR1C1 PDX1 NR2A1 IGF1 INSR SP3 APOB IGFBP7 UBE2Z PMC12219554__F1 Schematic illustration STAT3 SOST PMC7043073__F3 Impact of co-mutations on the microenvironment of KRAS-mutant lung adenocarcinoma KEAP1 MYC PMC4991528__F3 Recommended decision pathway for UK patients considered for treatment with tolvaptan according to Renal Association guidance based on the NICE decision FH EGFR PMC3706840__F8 PRL-Dependent Tyrosyl Phosphorylated PAK1 and 3D Collagen IV Regulate MMP-1 and MMP-3 Production and Invasion via MAPK Pathways Schematic representation of the proposed working model PAK1 MMP2 MMP3 PMC9418002__F2 BCL-2 family proteins CD40 BAX SYK BAD BCL2A1 IL4 IL6 PMAIP1 EIF4E MYD88 BTK FOXO4 BCR FOXO3A CXCR5 BCL2 BMF CXCR4 BCL6 PMC3725503__F1 Network of the mechanistic Target of Rapamycin (mTOR) signaling pathway RHEB TSC2 KLF2 TSC1 RS1 PMC5145311__F2 NLRP3, NLRC5, NLRP7, AIM2 and other inflammasome-like signaling is activated in response to S LTA NLRP7 NLRP3 AIM2 PMC3001303__F1 mTOR signalling pathway RHEB MLST8 TSC2 RICTOR PTEN MTOR IRS1 PMC7033713__F2 Summary of the effects of FGF19 signaling in specific cell types FGF8A NPY AgRP PMC5869511__F1 Antiviral innate immune pathways in dipteran insects CSA2 XRN1 AGO2 MYD88 PMC3006043__F3 Colorectal Cancer Molecular Biology Moves Into Clinical Practice PIK3CA EGFR BRAF PTEN GRB2 KRAS PMC9237101__F7 Model depicts the role of the IDO1-MDM2-p53 pathway in DLBCL growth BAX IDO1 MDM2 PMC7565746__F4 Diagrammatic representation of significantly differentially expressed genes associated with the fatty acid biosynthesis pathways, glycolysis, pentose phosphate pathway and TCA cycle when Schizochytrium was cultured under low-temperature conditions FAS PC PMC6090926__F1 Molecular interactions between LRRK2, aSyn and p38 MAPK in the regulation of apoptosis and autophagy CDC42 BAX LRRK2 MTOR RAC1 PMC4277436__F1 IL-33/ST2 pathway: therapeutic target and novel biomarker MAL IL33 TRAF6 MYD88 PMC4682238__F1 Schematic representation of Slit-Robo signaling pathway in gastric tumorigenesisᅟ SLIT2 DKK1 SRGAP1 MTOR ROBO1 CCND1 CTNNB1 PMC8820467__F2 Canonical Wnt/Beta-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering DOT1L SMAD1 DKFZp781O1323 APC LRP5 IHH LRP6 EZH2 RUNX2 RUNX3 CTNNB1 DKK1 SMO PMC3427704__F1 AID-associated gene network EXOSC1 ID2 SUPT5H CD40LG EXOSC8 YY1 IRF4 IRF8 EXOSC3 DIS3 EXOSC4 IL17C PRKDC PAX5 MSC UNG MDM2 EXOSC5 EXOSC6 BCL6 KPNA1 PMC3645661__F1 An overview of signaling by the EGF family (with EGF and EGFR/ErbB1 as example) from cell surface down to the nucleus (without taking into account endocytic trafficking and recycling of the receptor) TF LRIG1 EGF CBL SOCS4 EGFR PTEN GRB2 MTOR PMC4633896__F6 Mechanistic model for irradiation-dependent and GSK3Beta-related signaling in HNSCC cells: Activated and inactivated molecules are displayed in green and in red, respectively RICTOR GSK3B MTOR CTNNB1 EIF4E PMC355855__F10 Models for repression of TGFB signaling by the Smurf-Smad7 complex and reactivation of TGFB signaling by the Jab1/CSN5-Smad7 complex SMURF1 SMAD2 SMURF2 PMC4779708__F1 Schematic model of signaling pathways implicated in tumor cell vascular mimicry (VM) TF CD44 MMP14 EPHA2 SMAD2 SOX2 NODAL SRC TWIST1 PMC7232496__F7 Postulated mechanism of disease resistance in cattle to PPRV—Schematic representation of roles of differentially expressed genes IFI6 TLR3 IRF9 IFIT1 IFIT3 IFIT2 IRF3 IRF7 TLR7 ISG15 PDE12 PMC4425062__F6 Theoretical model of the negative regulation of the PA signal pathway by myostatin in skeletal muscle GDF8 MTOR PLCD4 PMC7559280__F3 Epigenetic modifications in the livers of male young adult IUGR-N mice ARHGEF28 TDRD5 CNIH3 SMAD2 HECW2 NFIL3 WNT5B GNAZ ALB RB1 VEGFB TRIM28 EVL FZD3 CSNK2A2 BCR F9 TDG RDX TDP1 DOCK7 FRS2 SEMA6B LRP5 KHSRP NCKAP1 FURIN EIF4E TCF3 ALDOB UBE2E3 ZNRF3 TWIST1 GNG7 ARID1A ARHG UBE2J1 RAB6B GABBR2 WTIP PCK1 PLXNA4 ZBTB18 IGF2R LATS2 MAP2K4 ACVR1B SIAH2 AEBP2 FOXJ3 LNX1 TNK2 RAC1 RAB15 GNB4 NEO1 RYBP GAB2 UNC5A PM20D2 PMC11983340__F1 Engineered metabolic pathway for the biosynthesis of disubstituted MAAs HEL107 tal-1 CYC1 PMC3676795__F2 Signaling cascades that regulate the intrinsic and extrinsic pathways of apoptosis BAX BAD PTEN BNIP3L FADD PMC6338478__F8 IGF-IR is now considered a functional RTK/GPCR hybrid, integrating canonical tyrosine kinase and GPCR signaling IRS4 MDM2 IRS1 PMC2593006__F3 Signalling pathways underlying neuronal survival and cognitive performance ARC MTOR BDNF PMC10377641__F3 Leptin: A Heavyweight Player in Obesity-Related Cancers TF STAT3 PMC8533426__F5 LRP-1 Matricellular Receptor Involvement in Triple Negative Breast Cancer Tumor Angiogenesis COL1A1 TGFB1 PLAT HEL-S-62p FST ANGPTL2 IGFBP1 CFH PLG PMC3731316__F1 Gene Network Analysis of Candidate Loci for Human Anorectal Malformations DKK4 DESI2 INTU EAF1 PROK1 ELL AMOTL1 WDPCP SOX6 SIL1 CDH18 WNT4 CTNNA1 SOX4 PMC2810084__F7 TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice TLR4 APC MYD88 PMC11651285__F1 First-line treatments for KRAS-mutant non-small cell lung cancer: current state and future perspectives EGFR GRB2 MTOR PMC8934501__SF1 GSK-3B suppression upregulates Gli1 to alleviate osteogenesis inhibition in titanium nanoparticle-induced osteolysis SMO RUNX2 PMC5595801__F2 Regulation and interaction network model of 17 cytokines IL10 IL3 IL13 IL4 IL2 IL1A IL6 IL5 IL1B IL9 PMC8541937__F6 Network pharmacology of triptolide in cancer cells: implications for transcription factor binding HEL-S-11 ERG PMC8027777__F9 Graphical illustration of proposed DEX-mediated preservation of mitochondrial fusion and fission involved in regulating HIF-1a/HO-1 pathway FIS1 OPA1 MFN1 MFN2 PMC7332729__F5 Influence of MCR on critical signaling pathways involved in embryonic myogenesis PIK3IP1 PIK3R5 CDC20 ZBTB12 GADD45G DTX2 RPS6KC1 RPS6KA2 ULK1 SMAD2 E2F7 IGF1R HDAC3 PIK3C2B EIF2S1 CDK6 MAML3 E2F3 GADD45B LFNG EIF5B NOTCH3 ULK2 CDC37L1 CDK4 BMPR2 EIF2B1 ADAM19 DLL4 ANAPC15 VEGFA WNT7B RBPJ MCM3AP FZR1 BMP1 IGFBP5 SUI1 MCM3 DVL3 AMHR2 BMPER MCM2 CDC25B PMC8727744__F3 Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy IFNG STAT3 CSF2 IDO1 ARG1 IL6 NEDD9 PMC11674667__F3 HIF signaling pathway in normoxic and hypoxic state EPO MMP2 MTOR VHL PMC8727744__F1 Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy IDO1 ARG1 CCL2 CDK4 PMC4399085__F3 PRC2-independent transcriptional activation by EZH2 in cancer STAT3 SUZ12 EED RBBP4 RELA RELB EZH2 CTNNB1 PMC7590591__F7 Pathway of anti-tumor activity of plumbagin in bladder cancer BAX CDK6 CCNE1 GSK3B CDK2 MDM2 MMP9 MTOR CCND1 CDK4 CTNNB1 PMC4614629__F1 Schematic illustration of the targets of actions by spermidine in different pathways MTOR PMC8554324__F1 Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities CD44 CXCL12 CD36 MSC PMC9035692__F3 Clinical Potential of Dental Pulp Stem Cells in Pulp Regeneration: Current Endodontic Progress and Future Perspectives FAS HGF HLA-G PMC6340995__F7 SNO profile of cell death network in Chagas disease (ChD) HEL-S-22 THBS1 PSMB3 ANXA1 CS YY1 FLNA HEL114 HEL-S-128m PNP HSPD1 TPM3 FGA HBB DKFZp761E1322 PMC5803173__F4 RBM20 structure and potential TTN splicing mechanism(s) regulated by RBM20 RRM1 RBM20 PMC5803173__F1 Striated sarcomere structure and TTN-mediated signaling pathway NBR1 FHL2 FHL1 SQSTM1 PMC6340995__F8 SNO profile of inflammation and immune responses network in Chagas disease HEL-S-22 THBS1 STIM2 VASP ANXA2 S100A8 ANXA1 TCF4 CS YY1 FLNA MPO HEL114 PNP HSPD1 GRB2 HBB PS1TP5BP1 CDK4 PMC7801429__F4 An ER signaling pathway network identified by IMPALA using Symmans data STAT3 SHC1 EGFR PIK3R1 KHDRBS1 MAPK14 WAS CHUK CSNK2A1 SRC JUN LCP2 INPP5D SNCA PTPN11 FOS NR3C1 CRK PRKCI NFKB1 CASP3 RPS6KA3 JAK1 LYN GRB2 LCK PMC3783160__F4 Model of the interactions of Rrp1 and Rrp2 with the mediators of two branches of HR DNA repair pathway and helicases Rqh1 and Srs2 RRP1 SWI5 RAD51 GC SFR1 PMC5940532__F2 Signal-transduction events in necroptosis IFNG TLR3 PGAM5 MLKL PPM1B PMC6336706__F4 Model showing the possible pathways of neuropeptide Y-induced neuroprotective effects in Alzheimer's disease NGF NPY BDNF PMC9462646__F4 Phase separation in immune regulation and immune-related diseases TBK1 CGAS IRF3 TREX1 PMC6846243__F7 Control case interaction visualized on RPGeNet showing the connections between NRL, NR2E3 and CRX retinal transcription factors CRX FIZ1 LIF AANAT SMAD4 PARK2 RHO RORB BANF1 EDF1 IGF1 FLT1 TMEM37 HNRNPK KAT2B PMC7368652__F2 GSK3B on myocarditis and dilated cardiomyopathy HMGB1 NLRP3 S100A8 MMP9 S100A9 IL1B CTNNB1 PMC9412694__F4 Impact of Epitranscriptomics on Antiviral Innate Immunity MAVS RIOK3 F3 IRF3 IRF7 PTEN PMC7174132__F1 Epigenetics/Epigenomics of Triterpenoids in Cancer Prevention and in Health CDH2 TGFB1 SP1 SMAD2 KDM5A EZH2 TERT IL6 TNF NOX4 YAP1 PARP1 RUNX3 MEF2D MYD88 CCNG1 LATS2 NR2A1 SP4 SP3 NFE2L2 HDAC2 HNF1A PMC5314913__F2 Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases IFNG RAB4A FH TGFB1 TNF LCK PMC10535870__F9 Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats BAX BCL2 MTOR PMC9429646__F1 Lipid rafts in cancer stem cell: a target to eradicate cancer CD44 CD24 SUFU APC GSK3B SMO CXCR4 CTNNB1 PMC9412694__F2 Impact of Epitranscriptomics on Antiviral Innate Immunity RHD MAVS STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IRF7 PMC7368652__F3 Phosphorylated GSK3B on polycystin-1/2 mutation of polycystic kidney disease SOST GSK3B AJUBA MIF MTOR CTNNB1 PMC3315579__F4 Loss of PTEN Is Not Associated with Poor Survival in Newly Diagnosed Glioblastoma Patients of the Temozolomide Era EGFR PTEN MTOR PMC7432215__F2 MUDENG Augmentation: A Genesis in Anti-Cancer Therapy? BAX CASP9 CASP3 APAF1 FADD PMC4835624__F1 Signaling through EGFR PTEN GRB2 MTOR PMC7826796__F1 Metabolic pathway of vitamin D (based on Feldman et al., 2014 , Jekinson 2019 and Dou et al., 2016 with own modifications) NR1i1 CYP2R1 CYP27B1 CYP24A1 DHCR7 CYP27A1 PMC7546314__F8 Cellular model summarizing potential mechanism of cucumber resistance to B ERF LOX MYC PMC9030443__F3 Is Nucleoredoxin a Master Regulator of Cellular Redox Homeostasis? Its Implication in Different Pathologies CAMK2A SEC63 NXN TLR4 AMER1 FLII RAC1 PMC2593077__F2 Hepatitis C and Innate Immunity – Recent Advances TBK1 TLR3 TLR8 CD14 IRAK1 IRF3 IRF7 TLR7 TRAF3 TRAF6 IRAK4 PMC11591800__F2 MTOR signal pathway RHEB ARF1 BNIP3 TBC1D7 DEPTOR IRS1 PMC6827047__F1 Parallel outline of several physiological roles of the TGFB/p38, mitogen-activated protein kinase (MAPK), and P13k/AKT/mTOR signaling pathways RHEB EGF TSC2 TSC1 EGFR PTEN MDM2 GRB2 MTOR PMC6827047__F3 Targeted components of the MAPK and AKT signaling cascades by small-molecule inhibitors in cancer BRAF PTEN MTOR PMC8702080__F1 Genetic Insights into the Impact of Complement in Alzheimer’s Disease C6 CD59 FH C7 HEL-S-62p C2 C9 VTN CS C4B_2 CR1 PMC4152843__F5 Comparative genome-wide transcriptional analysis of human left and right internal mammary arteries IL15 CXCL9 PRKD2 PYCARD FUCA1 IGLL1 SPARC CXCL3 APOL3 LPA DGKA CD74 HLA-F MHC2TA HLA-DMB UBA7 SELL SELE CD14 EHF BMX PTGS2 IL10RA HEL-S-125m RGS4 VCAM1 IL13RA2 PMC6027262__F4 Pathway overview of Salmonella carbon metabolism under Pi starvation RPE RPIA HEL-S-133P PMC6801800__F6 Endogenously derived chemerin mediates a tumor-suppressive effect through inhibition of Wnt/Beta-catenin signaling in adrenocortical carcinoma APC GSK3B CTNNB1 PMC6520904__F7 CXCR7-EGFR crosstalk and its effect on the MAPK signaling pathway CXCL12 EGF EGFR PMC7655184__F1 Summary scheme of the cholesterol-mediated hepatocyte and stellate cell crosstalk pathway in NASH LATS1 IHH PMC5561110__F12 Schematic representation of C5b-9-induced lysosomal dysfunction that inactivates autophagy in podocytes C6 C7 C9 PMC5314913__F1 Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases RHEB STAT3 ARF1 AMBRA1 AKT1S1 PTEN MTOR DEPTOR PMC11061361__F2 LIPUS holds potential as an effective approach to counteract synovial inflammation and fibrosis NLRP3 SQSTM1 HEL-S-30 CCND1 IL1B CTNNB1 PMC11061361__F3 LIPUS regulates chondrocyte function via multiple pathways ACAN CS RHO MTOR VEGFA SRC CTGF SOX4 CTNNB1 PMC6610330__F4 Model illustrating potential effects of cold stress on membrane lipid pathway in peanut LPA PGP PC PAH PMC4228940__F10 Novel Role of Vascular Endothelial Cadherin in Modulating c-Src Activation and Downstream Signaling of Vascular Endothelial Growth Factor CSK SRC PMC7888617__F2 Targeting oncogenic mutations in colorectal cancer using cryptotanshinone STAT3 EGF PIK3CA BAD WNT16 EGFR SMAD2 GSK3B PTEN MTOR CTNNB1 PDPK1 CCND1 JUN SP1 APC RAC1 FOS IRS1 ERBB3 RHEB TSC2 NRG1 HBEGF TSC1 RPS6KB1 ERBB2 BCL2 GRB2 PMC9064865__F5 6-Hydroxydopamine Induces Neurodegeneration in Terminally Differentiated SH-SY5Y Neuroblastoma Cells via Enrichment of the Nucleosomal Degradation Pathway: a Global Proteomics Approach ENG COMP KL PMC7888617__F4 Targeting oncogenic mutations in colorectal cancer using cryptotanshinone EGF BAD SP1 EGFR APC MTOR MYC RAC1 CTNNB1 ERBB3 RHEB HBEGF ERBB2 BCL2 GRB2 CCND1 PMC7888617__F3 Targeting oncogenic mutations in colorectal cancer using cryptotanshinone STAT3 EGF BAD SP1 EGFR APC PTEN MTOR MYC RAC1 IRS1 CTNNB1 RHEB TSC2 NRG1 HBEGF ERBB2 BCL2 GRB2 CCND1 PMC2893383__F2 Schematic of leptin signaling through STAT3 and PDE3B pathways in POMC and NT neurons in the hypothalamus STAT3 PDE3B POMC IRS1 PMC11312684__F2 GPx4 in the ferroptosis regulatory pathway: (a) GPx4 catalytic cycle representation SLC3A2 IPP LOX HMGCR SLC7A11 PMC3931425__F1 Diagram of known egg activation pathways in Drosophila, Xenopus, and mouse CORT CDC20 APC PMC11550995__F5 Noncoding RNAs in rheumatoid arthritis: modulators of the NFKB signaling pathway and therapeutic implications CD40 STAT3 LTBR BCL10 EGFR RELB TRAF2 MYD88 PMC8615218__F3 Siglecs as Therapeutic Targets in Cancer SYK SOCS3 SRC PMC11550995__F3 NFKB signaling pathway CD40 STAT3 LTBR BCL10 EGFR RELB TNF TRAF2 MYD88 PMC11312684__F1 GSH synthesis and transport of precursor amino acids: (a) Gamma-Glutamyl cycle of GSH synthesis CD44 SLC3A2 GLS SLC1A4 SLC7A11 SLC7A5 PMC11868168__F4 Metastasis from other organs to lungs via exosomes KLF4 HEL25 KDM6B CXCL12 KLF2 LIN28B COL6A1 ARHA PMC4171341__F3 Change or Die: Targeting Adaptive Signaling to Kinase Inhibition in Cancer Cells BAD NF1 ULK1 PTEN MTOR IRS1 PMC9638134__F6 Comprehensive analysis of endoplasmic reticulum stress and immune infiltration in major depressive disorder SYK LTA LAT IRF9 OSCAR CTSK FHL2 BLNK TNF DAO RAC1 LTB IFNG BCR ATM CYLD TRIM23 PMC11868168__F3 Lung cancer metastasizes outward through exosomes SIRT3 RAB27A PTEN SOX4 YAP1 PMC3159098__F2 Different RNA processing events in mammals TSEN15 RARS2 TSEN54 SEPSECS TSEN2 PSTK TSEN34 PMC9659743__F2 Dynamic and static biomechanical traits of cardiac fibrosis PIEZO1 ATR RHO PMC8262210__F5 Wnt3a/Beta-Catenin/CBP Activation in the Progression of Cervical Intraepithelial Neoplasia KLF4 WNT3A SOX2 TP63 CTNNB1 PMC5297658__F1 Representative apoptosis pathway and associated factors BAX FAS FADD PMC4832395__F4 Regulation of de novo lipogenesis by SREBP1c and ChREBP FAS F2 GSK3B ELOVL6 PKLR PMC3683958__F3 The dynamic regulation of NAD metabolism in mitochondria PNP NRK NAMPT PMC11889932__F4 Regulation of ferroptosis through the interaction of iron metabolism and the STAT3/NRF2 pathway STAT3 FTL STEAP3 KEAP1 GPX4 OGFR AHR SLC7A11 PMC3912738__F1 IGF signaling involvement in EMT GSK3B PTEN GRB2 SHE IRS1 PMC7484674__F6 Top 3 modules with relatively high scores from the protein-protein interaction network HEL164 FCAR SLCO4C1 C3AR1 TAS2R41 NMU CCL5 PNOC RAB27A PGLYRP1 SLPI E2F8 ORM1 SLC2A3 UBE2T GPR84 CFP CRISP3 HEL110 FPR2 IL8RB LCN2 TCN1 CYBB PTX3 CXCL12 TIMP1 CDC20 CD36 CXCL1 FOLR3 HJURP OLR1 DEPDC1B RETN KIFC1 CDC2 FCGR3B CLEC12A FEN1 OSCAR BST1 ARG1 MCEMP1 MMP9 CXCL6 TMEM63A CHI3L1 CXCR1 FCER1G LILRB2 MGAM PMC11889932__F3 Regulation of ferroptosis by JAK/STAT signaling pathways, focusing on the roles of different STAT proteins, including STAT1, STAT3, and STAT6, in modulating ferroptosis through pathways like SLC7A11 and GPX4 (Amino acid metabolism) SOCS1 HEL-68 CXCR3 STAT3 STAT1 GPX4 SYVN1 MCL1 SLC7A11 JAK1 CXCL10 HEL-S-64p PMC11889932__F2 This diagram illustrates the interconnected pathways involved in ferroptosis STEAP3 KEAP1 GPX4 LPCAT3 FACL4 ALOX15 HEL-S-64p PMC3912738__F5 Proposed model for the interaction between Shh and IGF signaling BMI1 GSK3B SHH SMO MTOR IRS1 PMC3912738__F4 The cross-talks between the Notch and the IGF signaling PTEN HIF1A MTOR IRS1 PMC11889932__F6 Ferroptosis and STAT signaling pathways by various compounds in cancer models STAT3 STAT1 GPX4 MTCH1 LPCAT3 GC FACL4 ALOX15 HEL-S-64p PMC3912738__F3 The interplay between the canonical Wnt/Beta-catenin pathway and IGF signaling APC GSK3B MTOR LEF1 IRS1 CTNNB1 PMC11889932__F5 Interaction of lipid metabolism pathways of ferroptosis with STAT proteins in human diseases STAT3 STAT1 ACSL1 LPCAT3 FACL4 IRF1 ALOX15 CPT1A PMC6677151__F6 The inhibitory effect of Gal-3BP on TAK1-dependent NFKB signaling pathway MAP3K7IP1 TRADD LGALS3BP TLR4 TAB3 IRAK1 TRAF6 TRAF2 IRAK4 IL1B MYD88 PMC4084431__F1 Genes directly related to dopamine functioning TH DRD1 DRD2 DRD4 DRD5 DDC DRD3 MAOA PMC3000440__F1 Decorin effects as an antiproliferative (left panel) and proliferative (right panel) molecule EGFR MTOR CTNNB1 PMC12066429__F5 Metabolic pathway reconstruction of M CYS1 HEL107 HEL-S-162eP FADD PMC11818536__F3 Tumor suppression and promoting mechanisms of LACTB LACTB GPX4 SLC7A11 MTOR TWIST1 PMC9476737__F4 Cytotoxicity of oleanane type triterpene from leaf extract of Pterospermum acerifolium (in vitro) and theoretical investigation of inhibitory signaling pathway TSC2 TSC1 PTEN MTOR PMC7468896__F7 LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling PMC5696504__F7 Osteogenic Wnt/Beta-catenin pathway and its interplay with polyphenols BCL9 SOST APC RUNX2 CTNNB1 PMC3918413__F4 Transforming growth factorB (TGFB) signalling pathway TF SMAD1 SMURF1 DKFZp781O1323 SMURF2 PMC3619006__F1 Proposed model for PDGF-D signaling pathway that controls the processes of EMT PDGFD MTOR CXCR4 PMC2647780__F1 Signaling Logic of Activity-Triggered Dendritic Protein Synthesis RHEB EEF2 BDNF EIF4E PMC5733023__F9 A schematic depicting the role of TLR4-NFkB-Caspase-11 signaling pathway in METH-induced astrocyte-related neuroinflammation NLRP3 TIRAP IL16 TLR4 IRAK4 MYD88 PMC4176946__F2 Ketone bodies as signaling metabolites SIRT3 NR1C1 TSC1 FOXO3A FGF21 SIRT4 SIRT5 FOXA2 SIRT1 PMC4736186__F11 Schema of signaling pathway involved in IL-1Beta-induced inflammation in microglia IL1R1 COX2 TLR4 IL1B MYD88 PMC6707123__F2 Schematic representation of the neural circuitry underlying the control of circadian rhythms NPS NPY PMC8875753__F1 miR-294 and miR-410 Negatively Regulate Tnfa, Arginine Transporter Cat1/2, and Nos2 mRNAs in Murine Macrophages Infected with Leishmania amazonensis NOS2 ARG1 ARG2 PMC7831311__F7 Important pathways affected by long-term 1-MCP treatment ACLY CAD ACO2 DLD HEL-S-32 CS PMC11014885__F4 Endosymbiont Tremblaya phenacola influences the reproduction of cotton mealybugs by regulating the mechanistic target of rapamycin pathway ETHE1 HEL20 SUOX PMC3761221__F4 Fear learning and memory across adolescent development Hormones and Behavior Special Issue: Puberty and Adolescence CA3 HEL-S-11 PMC4428600__F1 Wnting out ocular neovascularization: using nanoparticle delivery of VLDL receptor extracellular domain as Wnt pathway inhibitor in the retina LRP5 LRP6 CTNNB1 PMC5673678__F4 iCOS pathway associated with HIV-1 TAR target genesiCOS signaling in T helper cells CD40 ICOS CD80 BAD APC CSK PTEN VAV1 GRB2 RAC1 GAB2 LCK PMC4723085__F4 Uncovering New Pathogen–Host Protein–Protein Interactions by Pairwise Structure Similarity PSMD10 MAPK11 PPP5C FAF1 ARHA UBE2D1 MAPK14 HEL-S-71 CDKN2A PRDX3 NFKBIA UBE2D3 DKFZp761E1322 PMC6608049__F2 Molecular pathways involved in the maintenance of the MDSC suppressive function.A wide variety of proinflammatory factors are involved in the induction of the suppressive function in MDSCs STAT3 STAT1 CD74 COX2 IL3 IL4 IL2 IL7 IL6 MIF IL5 PMC9309082__F2 Copper in the tumor microenvironment and tumor metastasis ATOX1 HDAC1 TET1 MEF2D PMC10878147__F1 Illustration represents the polyphenols targeting the NFKB pathway associated with Alzheimer's disease NLRP3 APP TNF PMC4823852__F8 MicroRNAs upregulated in OSCC repress multiple genes in the p53 signaling pathway RFWD2 BAX CASP9 ATR FAS SIAH1 PERP PTEN MYC TSC2 CASP3 CDK2 ATM RRAS PIGS MDM2 PMC4823852__F7 MicroRNAs downregulated in OSCC target multiple genes in the PI3K/AKT pathway RPS6 SYK BAD PTEN CD19 MTOR RAC1 EIF4E RHEB HRAS TSC2 BOLL BCR PI3 CHUK MDM2 PMC7765227__F3 Signal transducer and activator of transcription (STAT)1 and STAT3 pathways in the inflammatory response SOCS1 STAT3 STAT1 UBA7 PIM1 IRF7 CCL5 PMC7765227__F2 Role of the inflammation-associated transcription factor signaling pathway (NFKB) and mitogen-activated protein kinase (MAPK) pathways in the inflammatory response VCAM1 TRAF6 IL1B MYD88 PMC3342067__F4 CD44 potentiates T cell activation, expansion, contraction, and maintenance of memory cells CD44 ZAP70 FAS CASP8 CD69 APC IL7R LCK PMC8961894__F1 DNA in extracellular vesicles: from evolution to its current application in health and disease CD81 RAB31 CD9 CD63 PMC5074356__F1 Signal transduction mediated by the extracellular calcium-sensing receptor (CaR) HEL-S-11 ARHA PMC2814543__F4 Nutrient sensing and inflammation in metabolic diseases RHEB TSC2 SOCS3 MTOR TNF PMC6196465__F5 Lipid synthesis pathway in porcine mammary gland DGAT1 ACSL3 LPIN2 CD36 SCD FASN PLIN5 FADS2 ELOVL1 ACSS3 ACACA FADS1 ACSS2 GPAM BTN2A1 ADFP XDH PMC6196465__F3 Milk protein synthesis pathway in porcine mammary gland LYZG LAT2 PMC6196465__F2 Lactose synthesis pathway in porcine mammary gland B4GALT1 LYZG HK2 PMC2715245__F7 Comparison of models for FRAXA and APC-inducible chromosome fragility ATR APC ATM PMC4175348__F11 A putative scheme for ATF3-mediated regulation of ER stress-induced cancer chemokine expression ATF3 EGR1 PMC7847067__F1 Adropin: a hepatokine modulator of vascular function and cardiac fuel metabolism PDK4 GPR19 NOTCH1 PMC4919024__F6 The pathway of EGF induced anticipatory UPR activation EGF EGR1 EIF2A FOS BIK PMC4184971__F4 Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention BAX SUMO1 CAD MAP2K4 RIPK1 BMF NUMA1 FADD PMC11541728__F2 Signalling pathway of ephrin receptors (EphR) is depicted CDC42 RHO SRC RAC1 PMC6445055__F6 Gene networks and canonical pathways generated by Ingenuity Pathway Analysis VDAC3 MRTO4 RPL10A EZH2 SP110 SPCS2 RPL30 VHL CP PMC4797117__F2 ML-hGRN for putative pluripotency renewal pathway in human embryonic stem cells FUS STAT3 SKIL REST PRDM14 OPA1 NFYB SET DPPA4 ZIC3 ZNF580 PBX3 SCML2 OTX2 CEBPZ ENPP2 GTF2F2 ZIC2 PMC4811486__F5 NF-Y activates genes of metabolic pathways altered in cancer cells GLDC SLC3A2 GLS DHFR GFPT1 HEL-S-51e GLUD1 GC AMT SHMT1 MTHFD1L MTHFD2L SLC25A32 NNT GPT MTHFD2 SLC18A1 GOT2 CAD ME1 HEL-S-70p GCSH PHGDH ME2 DLD PSAT1 PFAS PSPH PMC7702664__F5 Visualization of KEGG pathway of the genes altered in the CUBN neighborhood in CRC LRAT HEL-S-11 PMC8415109__F1 Non-coding RNA Activated by DNA Damage: Review of Its Roles in the Carcinogenesis CDC2 AXL MARK4 ARHA MYC VGLL4 CTNNB1 LATS1 CTCF BIRC5 TIAM1 AMOT NLK NF2 CCND1 PMC7382314__F7 Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney TNF HES1 PMC2720031__F1 GR signal transduction pathway TPR IGF1 CX3CL1 PMC8206466__F1 Tyrosol as a Neuroprotector: Strong Effects of a “Weak” Antioxidant STAT3 BAX BCL2 HEL-S-44 PMC6485955__F4 FGF21 Signaling Network in Adipocytes MAPK1 FGF21 CRTC2 UCP1 MTOR NCBP1 NFIA MAPK3 RHEB MLST8 MAP2K4 FGFR1 ATF7 GRB2 GAB2 BCL6 PMC5467317__F1 Cholesterol and isoprenoid synthesis pathway which shows the inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase by statins CDC42 ARHA RAC1 PMC5434646__F6 Proposed mechanism of the interplay between mitochondrial complex II and FH in the stabilization of the HIFA signaling pathway SDHD TH SDHA SDHB FH SDHC PMC6839211__F8 MicroRNA-182 in ovarian cancer NCAPG HMMR ORC6 CDC6 BRCA2 ORC1L GINS4 KIF23 CTNNB1 BIRC5 FYN CDK6 RPA3 PRC1 SMC2 CCND1 TOP2A SMC4 GINS1 GINS3 CDK4 YES1 RAD51 ECT2 DTL ORC3 KRAS ORC2 MCM7 MCMBP CDKN1A MCM10 CDC45 GINS2 MCM3 MCM5 MCM6 MCM2 PMC5946182__F4 Proposed anti-inflammatory pathways based on reviewed nutritional interventions CRP COX1 IL6 PMC8466575__F8 Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy APC ARF6 TRPC1 PMC12103778__F5 Cytoneme-mediated Wnt signaling in gastric cancer ROR2 LRP5 LRP6 WNT3 PMC12103778__F4 Cytoneme-mediated self-organization and asymmetric cell division in stem cells WNT3A CTNNB1 PMC9198382__F4 Advances in the systemic treatment of therapeutic approaches in biliary tract cancer ALK BRAF GRB2 PMC8468691__F6 4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells CDC2 BAX MTOR CCNB1 CCND1 APAF1 CDK4 PMC3248149__F3 Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence RHEB RPS6 TSC2 TSC1 GAS2 PTEN MDM2 EIF4E PMC3175103__F4 Dysregulated TRK Signalling is a Therapeutic Target in CYLD Defective Tumours NTF3 NTRK1 MAPK7 NTRK2 NTRK3 BCL2 TRAF6 CYLD UBE2L3 MAPK6 PMC3248149__F1 Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence BAX MDM2 CCND1 PMC4302087__F3 MiR-101 network regulates EMT EZH2 ZEB2 CTNNB1 PMC5499908__F1 Force transmission and mechanotransduction from the extracellular matrix (ECM) to the nucleus NR1B3 FRK SUN1 MRTFA RHO CTNNB1 LBR PMC3066468__F7 Scheme of cross-talk interactions between liver IR and TIM-1 signaling CXCL1 CXCL2 IL1B PMC10534675__F1 Recent Advances in the Treatment of Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases BMPR2 PAH PMC5070052__F4 Schematic presentation of how the rs17228616 single-nucleotide polymorphism (SNP) in the acetylcholinesterase (AChE) gene may affect the vulnerability to stress CDC42 ACHE PMC3576812__F1 The hedgehog’s tale: developing strategies for targeting cancer SUFU PTCH1 SMO PMC2575905__F1 Current concepts of the amino acid signaling pathway leading to protein synthesis RHEB EEF2K TSC2 TSC1 EIF4E PMC4621105__F2 Common cellular processes important in coronavirus replication VNN1 RNF128 PRPF18 PPIH RHBDD3 TMEM18 ATP2A2 VCP KPNA2 ERF PRPF6 TMEM41B DDX1 SNRPD1 PES1 EIF3F EEF1A1 KCNG1 PPAN ARF5 CCND1 CDC5L CLDN5 HNRNPL ABCE1 RSL24D1 DDX5 EIF4B SCD UBE2M COPZ2 CWC15 RPS7 GBF1 RBX1 RPS20 EIF3E POLR2B PLRG1 UBE2I PMC9300927__F6 Identification of circRNA–miRNA–mRNA Regulatory Network and Crucial Signaling Pathway Axis Involved in Tetralogy of Fallot GPR137B STAT3 MAP3K10 PDCD1 VLDLR PIK3R1 ANKRD33B RGMA KRABD4 SOCS3 ABHD2 SNN E2F3 NREP FBN2 SOX4 FBN1 IGF2BP1 HEL-S-133P PRDM1 LIMK1 PTGFRN ADAMTS9 RAPGEF4 FURIN COL2A1 STEAP3 HAS2 CXCR4 COL21A1 P4HA2 FREM2 AMOTL1 SLC7A11 MTSS1 KPNA2 LITAF TUBB2A F3 MEGF9 LDLR GAS1 MAP2K3 AQP4 ZNF385A RHPN2 BACH2 CLCN3 E2F2 TET1 NACC2 RRM2 KLHDC3 BCL2L11 MKX SPP1 LOXL4 ZNF711 TNFRSF11B PMC5308720__F6 Expression/activation of A5B1 integrin is linked to the Beta-catenin signaling pathway to drive migration in glioma cells HEL113 CTNNB1 PMC6775302__F9 Proposed signaling network of regulating the formation and development of seminal vesicle tumors in TRAMP mice CDC2 STAT3 EGF CDK6 EGFR EZH2 CCNB1 CCND1 CDK4 PMC6202086__F4 The mechanisms involved in the maintenance of b[Ca2+]i RYR2 TRPC3 PMC6896088__F3 Associations between the autophagy pathway and MAPK signaling in to tumor tolerance against targeted therapies and chemotherapies ATF3 ATF4 ASNS ATG5 PMC6836113__F10 Continuous impaired insulin signalling causes the activation of AD markers (GSK3B and TAU genes), thus increasing the amyloid beta aggregations leading to AD VIT GSK3B PMC8415109__F3 Non-coding RNA Activated by DNA Damage: Review of Its Roles in the Carcinogenesis PXN ROCK1 ARHA PMC7021704__F6 Main pathways in O GAL HEL-S-5 PDC PMC3492204__F5 A simplified scheme to illustrate the dual roles played by KIF7 in Indian Hedgehog (IHh) signaling and chondrocytes development KIF7 IHH SMO PMC6394552__F4 A feedforward mechanism in TGFB signaling SMURF1 SMAD2 SMAD4 SMURF2 TGFBR1 PMC11989323__F2 Biosynthetic pathway of NAPE and NAE NAAA ABHD4 FAAH HRASLS5 GDE1 PMC10037406__F5 Posttranslational modification in the cGAS-STING pathway TRIM13 TRIM14 RNF185 TBK1 TRIM38 CGAS TRIM32 TRIM56 RNF5 IRF3 RNF26 TTLL6 TTLL4 PPP6C RNF115 MUL1 AMFR SENP2 TRIM29 PMC10037406__F1 CGAS-STING signaling pathway TBK1 CGAS IRF3 PMC6160542__F1 Fibrogenic secretome pathways in the development of fibrosis DKK3 DKK1 GSK3B LRP5 LRP6 SIRT1 CTNNB1 PMC6714585__F21 Most potent small molecules capable of inhibiting Hh pathway with their mode of action SUFU PTCH1 SHH SMO PMC9259561__F4 PD-L1 regulates cell proliferation and apoptosis in acute myeloid leukemia by activating PI3K-AKT signaling pathway VWF EGF FREM1 F2RL3 COL6A6 NMU PTEN GP5 FGF10 ITGB3 CTSG ITGA2B RELN IRS1 MPO PLAT MAGI1 PRL COL6A5 ELANE PLOD2 GRB2 AVP PF4 PMC8366450__F5 Human CPPED1 belongs to calcineurin‐like metallophosphoesterase superfamily and dephosphorylates PI3K‐AKT pathway component PAK4 PHLPP2 PAK4 HEL-S-28 PTEN PDK2 CPPED1 PMC5329687__F1 Nitric oxide dose effect on mitochondrial function and endoplasmic reticulum stress TFAM CRIPTO MB PMC8880704__F9 Network Pharmacology Study to Reveal the Potentiality of a Methanol Extract of Caesalpinia sappan L. Wood against Type-2 Diabetes Mellitus EHHADH CD36 FABP1 UCP1 FADS2 PCK1 ACADM SLC27A5 OLR1 CYP7A1 PDPK1 CPT2 APOA5 CYP27A1 LPL APOC3 ACOX1 UBC NR1H3 CYP8B1 SCD HEL-S-28 FABP4 ME3 HMGCS1 APOA2 ACSL1 ANGPTL4 AQP7 DBI RXRA ACADL PLTP ADFP SLC27A4 PMC3443185__F1 Two mechanisms underlying circadian control of NFKB response PER2 CRY2 CRY1 PMC11573773__F3 Regulatory pathways of ABCC5 in cancer BMI1 FOXM1 KEAP1 ABCC5 PMC11573773__F2 SLC34A2-Bmi1-ABCC5 signalling pathway hypothesis diagram BMI1 SLC34A2 ABCC5 PMC4640739__F7 Working model for Mek/Erk signaling in mouse ESCs KLF4 PRDM14 TBX3 PMC3889255__F1 CRH signaling pathway - This map represents the NetPath reactions of CRH signaling pathway GNAO1 CRH BRAF TCF4 MAPK3 GNAZ GNB1 PLCG1 PRKCE PLCG2 PRKCA POMC JUN STAR ARRB2 TFAP2A TEX19 ARHA FOS PARP1 ECE1 NFKB1 RELA GNA11 NFKBIA CRHR2 BCL2 MAP2K1 PMC9221189__F5 O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway LATS1 OGT LATS2 SMAD2 DLL4 GSK3B LRP5 SMAD4 LRP6 TCF4 RHO CTNNB1 PMC2926749__F4 Proposed model for MALT1 function in NFKB activation BCL10 BCR TRAF6 PMC9536081__F6 Absence of ID2 results in an altered photic responsiveness of the circadian system ID2 PER1 PMC8616424__F1 Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer’s Disease BAX CGAS NLRP3 CD36 TLR9 IL1B PMC9365986__F2 Immunoregulation effect of tumor microenvironment in pancreatic ductal adenocarcinoma CD44 CD24 CTNNB1 PMC4425275__F3 Original and reduced EGFR models EGF NGF RAF1 EGFR NGFR PMC8761737__F8 Transcriptomic and Histological Analysis of Exacerbated Immune Response in Multidrug-Resistant Pseudomonas aeruginosa in a Murine Model of Endophthalmitis TIMP3 GFAP NLRP3 TRAF6 TNF MPO PMC6186418__F2 YAP/TAZ upstream signals and downstream responses LATS1 LATS2 TIAM1 APC LRP5 LRP6 RHO PMC6757264__F7 Mitogen-activated protein kinase signaling pathway in lung squamous cell carcinoma MAX JUN FAS BAP1 CD14 NLK TRAF6 TNF FLNA PMC5302973__F7 Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells CD44 GSK3B TWIST1 CTNNB1 PMC6981639__F1 The primary metabolic pathway of mammalian gangliosides UGCG GM2A B3GNT5 B4GALNT1 ST8SIA5 ST3GAL5 ST8SIA1 B4GALT5 B3GALT4 A4GALT PMC2696359__F1 TNF-Induced MAP Kinase Activation Oscillates in Time TRADD TRAF1 CDC37 TNF TRAF2 PMC8171813__F1 Immune cell involvement after cardiac injury CRP NLRP3 CCR2 PMC8326758__F1 Fibroblast Growth Factor 21 in Diabetic Cardiovascular Complications and Related Epigenetic Mechanisms BAX FYN FGF21 PON1 PMC8698717__F3 Neutrophils and Platelets: Immune Soldiers Fighting Together in Stroke Pathophysiology VWF COX1 VCAM1 IL8RB PMC3797807__F4 Cell Survival Following Radiation Exposure Requires miR-525-3p Mediated Suppression of ARRB1 and TXN1 TH MS4A1 GLS TXNIP PPP5C MYC HEL-S-100n TRAF6 FLNA IFNG TXN IL1R1 HSPD1 PRDX3 CD74 CDK7 AHR HNRNPK PSME2 TPT1 CASP9 NOS2 HINT1 ARRB2 SELE GCLM TNF CYP1A1 RBX1 CUL4B RELA BCL2 RPS6KA3 MAP3K5 PMC4168754__F1 Cardiac Hypertrophic Response pathway loaded as a pathway COMP CDK7 GSK3B HDAC5 POLI MTOR PMC9345703__F8 Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways TBK1 STAT1 CGAS TLR3 IFNAR2 IFIT1 IFNAR1 IRF3 OAS3 JAK1 PMC6459169__F4 Transcriptional coverage of penguin transcripts on the vertebrate Janus kinase/signal transducers and activators of transcription (JAK-STAT) (#04630) (A) and vertebrate Toll-like receptor (TLR) signaling pathway (#04620) (B) MAFK LAT PIR CD14 PMC7765985__F2 Networks generated from genes altered in intestinal- and diffuse-type gastric cancer (GC) RALA PAH PMC6459169__F3 Transcriptional coverage of penguin transcripts within the vertebrate nuclear factor kappa B (NFKB) signaling pathway (#04064) LTB LTA LEP LAT BLNK MIP TRAF6 TNF DAO LBP PMC11936485__F8 Mechanism and signaling pathways of the inhibitory effects of HST on the proliferation of LUSC cells CDC2 BAX CASP3 EIF2A CCNB1 NOTCH1 PMC7473788__F5 Working model proposing how TFAP2C functions downstream of the Hippo signaling pathway to regulate Cdx2 expression in the outside polar cells LATS1 CDX2 LATS2 AMOT SOX2 TFAP2C NF2 YAP1 TEAD4 PMC7473788__F4 Working model proposing how TFAP2C and TEAD4 promote formation of the apical domain, which in turn, negatively regulate LATS1/2 activity in the outside polar cells LATS1 LATS2 ROCK2 PARD6B ROCK1 TFAP2C ARHA TEAD4 PMC7473788__F3 The Hippo signaling pathway in mouse preimplantation embryos LATS1 CDX2 WWTR1 LATS2 AMOT NF2 YAP1 TEAD4 PMC9221189__F1 O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway LATS1 LPA LATS2 PMC183833__F2 Canonical Wnt/Beta-catenin pathway FRAT1 APC LRP5 TBP CCND1 CTNNB1 PMC4015472__F3 Post-Transcriptional Regulation of Interferons and Their Signaling Pathways IFNG STAT1 IFNGR2 IFNGR1 HEL-S-162eP STAT4 JAK1 PMC4015472__F2 Post-Transcriptional Regulation of Interferons and Their Signaling Pathways IRAK1 IRF3 IRF7 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR4 MYH7 IFNAR1 TLR7 MYH7B JAK1 TYK2 PMC9530146__F6 Mechanisms of acupuncture for neuropathic pain based on somatosensory system CX3CR1 CX3CL1 BDNF PMC3504364__F2 Methotrexate (MTX) mechanisms of action in the folate metabolic pathway MTHFD1 ABCC1 DHFR MTRR GGH SLC19A1 ABCG2 INS ABCC2 FPGS ABCB1 PMC4419202__F4 Upstream analysis focused on transcription factors after Foxa1 knockout in female bladders RBL1 TCF3 KRT10 RELB TP63 TAF4B CD133 MDM2 FOS NOTCH1 PMC4419202__F3 Most enriched pathways after Foxa1 knockout in female bladders KRT10 KRT12 PPBP RELB TP63 MDM2 REL PMC6534496__F6 Outline of the main altered pathways in SiNETs FZD5 LRP4 PMS2 EGFR SMAD4 PTEN MTOR CTNNB1 OGG1 MUTYH SRC MGMT MSH6 MSH2 MSH3 APC LRP5 LRP6 IPMK VHL HEL-117 MSH4 TSC2 TSC1 CDKN1A CDKN1B MAP2K2 PMC4419202__F1 Most enriched pathways after Foxa1 knockout in male bladders TNLG2A KLF6 ORM1 PMC8302727__F2 Proposed biosynthetic pathway of ARTs based on the two-polyketide-chain assembly model ART4 PMC10904539__F2 AhR in tumor energy metabolism HK2 HEL-S-162eP AHR SUV39H1 PMC8402591__F1 Efficacy of COVID-19 Vaccines in Chronic Kidney Disease and Kidney Transplantation Patients: A Narrative Review CD80 APC EPO MTOR PMC6005849__F4A Resolvin E1 Promotes Bone Preservation Under Inflammatory Conditions IFNG TH SYK CTSK RAE1 FHL2 GRB2 TNF CYLD RAC1 PMC6956807__F8 Proposed model for miR-204-5p-SNAI2/SUZ12/HDAC1/JAK2/STAT3 regulatory circuit in HNSCC progression STAT3 SUZ12 SNAI2 EZH2 PMC9310501__F4 STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis STAT3 LIF OSCAR MMP9 PMC8845065__F6 Retinoic acid synthesis and signaling RARA ALDH1A3 DHRS9 HEL-S-53e RARB CRABP2 ALDH1A2 PMC9310501__F3 STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis STAT3 CEBPA RPN2 LIF LEPR WNT4 SOCS3 RAC1 CTNNB1 PMC8385858__F8 Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer CD69 MMP2 BCL2 CCND1 CDK4 PMC11019011__F3 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity DNMT3B DACT1 IGF1 AXIN1 IL18 IL6 RHO RUNX2 AXIN2 CTNNB1 PMC4280579__F7 Integrated model of NDV-3–mediated protective efficacy versus MRSA in murine SSSI STAT3 IL16 APC PMC11019011__F5 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity DKK1 IL18 NFATC1 IL6 RUNX2 PMC11019011__F4 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity SMAD1 DKFZp781O1323 SMAD2 SMAD4 RUNX2 PMC7582838__F2 Modified tricarboxylic acid (TCA) pathway in cyanobacteria PDC PMC11019011__F6 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity IL18 NFATC1 IL6 PMC5002299__F3 Regulation of the NLRP3 inflammasome activation by the ubiquitin-proteasome system NLRP3 IL16 TRAF3 TRAF6 BRCC3 PMC5002299__F1 Regulation of TLR4 signalling by the ubiquitin-proteasome system MYSM1 OTULIN TAB3 MAL IRF3 TRAF3 TRAF6 MYD88 USP15 USP4 TLR4 USP18 USP20 CYLD PMC4384737__F2 Nucleotide sugar UDP-GlcNAc resides at the nexus of protein and lipid glycosylation OGA TPR OGT PGM3 PMC8394439__F1 Microbiota-Associated Metabolites and Related Immunoregulation in Colorectal Cancer IL10 IF2B1 GC NFATC3 FOXP3 TNF LAG3 PMC3825415__F3 FGFR signaling pathway CDC42 CRK CBL SHB FRS2 RHO GRB2 DOCK1 ERAS PMC3756518__F1 Schematic of the simplified B-cell receptor (BCR) signaling pathway simulated in our Monte Carlo method SYK BCR LYN PMC10300974__F5 Hypericum perforatum L. and the Underlying Molecular Mechanisms for Its Choleretic, Cholagogue, and Regenerative Properties † BAX EGFR S100A8 HEL-S-28 CXCL2 IL8RB SRC PMC8005494__F2 Molecular mechanism of pyroptosis STAT3 HMGB1 GSDMD GSDMC GZMA GSDMB DFNA5 PMC4068285__F4 LM infection in microglia SCARB2 STAT1 BAD CD14 CCL4 SMPD1 JAK1 PMC9557975__F2 Activation of TLR4 by viral glycoproteins: A double-edged sword? TIRAP TLR4 CD14 IRF3 MYD88 PMC4253844__F2 Cholesterol in brain disease: sometimes determinant and frequently implicated APOE ABCA1 PMC9604348__F10 Transcriptomic and Physiological Analyses Reveal Potential Genes Involved in Photoperiod-Regulated Beta-Carotene Accumulation Mechanisms in the Endocarp of Cucumber (Cucumis sativus L.) Fruit RFWD2 MYB CSNK2A1 PMC4253844__F1 Cholesterol in brain disease: sometimes determinant and frequently implicated NPC2 NPC1 HMGCR DHCR24 DHCR7 PMC5005280__F3 Core Hippo pathway LATS1 TEAD2 TEAD3 NF2 TEAD4 PMC5751143__F1 Induction of PD-L1 by IFNG signaling pathway and microRNAs target the key genes in the pathway EIF4B IRF1 PTEN MTOR PMC7343830__F6 Proposed regulatory mechanisms of blood circulation for hypoxic adaptation in Tibetan chickens EMP2 NCALD VAV2 HK2 STK4 NUMB CTSA MTOR MLST8 NLN APOH CASQ2 PLCB1 HEL-S-102 ACE2 PMC8487426__F4 Alcohol use disorder (AUD)-associated miRNA–mRNA regulatory networks in the amygdala (AMY), the caudate nucleus (CN), the cerebellum (CRB), and the hippocampus (HIP) of AUD subjects (the Set 1 sample) SYT9 HMOX1 THBS1 INA CP PMC8487426__F5 Alcohol use disorder (AUD)-associated miRNA–mRNA regulatory networks in the nucleus accumbens (NAc), the prefrontal cortex (PFC), the putamen (PUT), and the ventral tegmental area (VTA) of AUD subjects (the Set 1 sample) ARHG WAS CP PMC8323660__F2 Epigenetic Changes in the Progression of Alcoholic Steatohepatitis SIRT3 UFC1 PNPLA3 UFM1 MTF1 SIRT1 SIRT6 UFSP1 PMC8381650__F5 NFKB: At the Borders of Autoimmunity and Inflammation FAS CCL21 BCL2 AIRE IRF4 FOXP3 PMC8381650__F4 NFKB: At the Borders of Autoimmunity and Inflammation ZAP70 SYK TRADD CARD11 OTULIN IRAK1 TRAF6 IRAK4 MYD88 BCL10 C2 BCR NOD2 TRAF5 LYN TRAF2 LCK PMC3560853__F3 Scheme showing the potential molecular events induced in cancer cells in the hypoxic tumour microenvironment HEL-S-68p SOX2 BCL2 IL6 MTOR ABCG2 HEL-S-30 MYC CXCR4 VHL PMC8476812__F6 Targeting Histone Modifications in Breast Cancer: A Precise Weapon on the Way GREB1 MMP7 KLF2 SIAH1 RAD51 FOSB PER2 EZH2 SOCS3 TNF MYC RUNX3 LOX MHC2TA FOXO3A CDKN1B FOXC1 MMP2 CDKN1C CXCR4 SOX4 NOTCH1 BIK PMC5562928__F2 Amino acid degradation in I GLDC GOT2 GLS KYNU FICD SUOX AFMID GCSH HAL AMT DLD GSTZ1 PRODH AASS PMC9598921__F4 Chromosome-Level Assembly of Male Opsariichthys bidens Genome Provides Insights into the Regulation of the GnRH Signaling Pathway and Genome Evolution CDC42 EGR1 MMP2 GRB2 PMC5562928__F1 Amino acid synthesis in I AGXT2 ASPG PHGDH CTH PSAT1 PAH PMC9133560__F4 Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles SMAD1 DKFZp781O1323 APC LRP5 SHH LRP6 TNLG7C CTNNB1 PMC7417299__F5 Chemokine signaling pathway from KEGG has the highest counts for selected feature genes BAD ARHA GRB2 SHE DAO PMC2585609__F1 A schematic representation of the functional domains of Stim and Orai proteins ORAI3 STIM2 ORAI1 PMC6772062__F1 Canonical Wnt/B‐catenin and divergent signaling pathways GSK3A APC GSK3B LRP5 LRP6 MTOR LEF1 CTNNB1 PMC7765110__F9 The proposed pathways by which melatonin regulates testosterone production and protects the testicular tissue from oxidative damage in LPS-induced sheep orchitis SF1 STAR TLR4 IL1B PMC3942726__F1 Simplified schematic diagram of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway and proposed cellular regulation of muscle protein synthesis in response to hypoxia, caloric restriction, insulin, muscle contraction, and leucine RHEB RPS6 TSC2 TSC1 EEF2 PMC4491883__F1 NetworkPainter enables researchers to quickly draw publication quality signaling diagrams ZAP70 SYK BTK BCR BLNK MTOR PMC8021759__F1 Methods to circumvent antiviral immunity STAT2 IRF9 KLRG1 PMC4830836__F1 Notch canonical and non-canonical signaling HIF1A YY1 CTNNB1 PMC8955653__F2 An Expanding Toolkit for Heterochromatin Repair Studies RAD52 TOPBP1 ATR ATRIP RAD51 LIG1 DNA2 BRCA2 ATM BLM PMC8535589__F1 Cell Death and Survival Pathways Involving ATM Protein Kinase BAX FAS GSK3B ATM PMC6386894__F3 cAMP regulates immune response of astrocytes CSA2 HEL-S-62p VCAM1 CCL2 PMC10952836__F1 Signaling pathways involved in ferroptosis regulation SLC3A2 TEAD2 STEAP3 GPX4 LPCAT3 FACL4 SLC7A11 ADA PMC8624829__F4 Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway ACHE PPARG NOS2 CACNA1A PIK3CA CACNA1C PRKCB MAPK3 MAPK14 MYLK PLCG1 CHRM2 PRKCA ADRB2 EDNRA CFTR ELANE SRC REL PMC6915518__F3 Molecular mechanisms of pro- and anti-inflammatory effects of NPs on MФs IFNG CD80 IL10 NLRP3 TLR3 TLR4 TLR7 MARCO IL1B SRA1 PMC7760557__F10 Melatonin in mitochondria of NLRP3−/− mice during cardiac aging HMOX1 NLRP3 KEAP1 AMT MFN2 FADD PMC120784__F11 Upper part of the glycolytic pathway and pathways for production of glycerol, trehalose, and glycogen, with all proteins and their isoforms indicated tal-1 HEL-S-49 PMC7236196__F7 Combined proteomics and metabolomics pathway network map of significantly altered metabolites and proteins in ERG-positive prostate cancer compared to ERG-negative prostate cancer APRT EHHADH NTS ACSL1 PC ERG PMC9043600__F1 Long Non Coding RNA Based Regulation of Cerebrovascular Endothelium STAT3 BAX PAK1 BCL2 HIF1A VEGFA TUG1 ULK2 PMC6626573__F6 Targeting of lung cancer stem cell self-renewal pathway by a small molecule Verrucarin J FOXM1 APC CTNNB1 PMC8624829__F5 Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway ACHE CAV3 GAA PLN CAV2 CYC1 POR HRC C2 BCR PI3 MCU ChAT MB PROC PMC8026084__F9 IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling DOT1L CSA2 CHD4 EZH2 PMC7873355__F3 Interaction network showing the mutual involvement of DEPs from SACS KO model and ARSACS patients in Engulfment of Cells (A) and Synaptogenesis Signaling Pathway (B) ICAM5 EPHB2 EFNB2 PER1 APOE SNCA EPHA3 MB CP PMC4397846__F1 Pathway on the left is that of an active cell APC CTNNB1 PMC5819688__F6 Anacardic acid and signaling pathways GEM ATM CHMP1A PMC6658002__F3 Other stimuli leading to necroptosis TLR3 STAT2 MLKL TLR4 TNF FADD PMC4681826__F1 Signaling pathways activated by BCR-ABL CRK BAD CBL CRKL MDM2 GRB2 GAB2 PMC6658002__F2 TNFR1-mediated signaling pathways TRADD MLKL TRAF5 CYLD TRAF2 FADD PMC8851069__F4 Advances in cGAS-STING Signaling Pathway and Diseases TFAM BAX CGAS PMC6594827__F2 Other fatty acid metabolism targets KLF4 ACOX1 NR1C1 FASN MGLL CPT1A PMC8851069__F3 Advances in cGAS-STING Signaling Pathway and Diseases CGAS NLRP3 IRF3 PMC8851069__F2 Advances in cGAS-STING Signaling Pathway and Diseases CGAS TLR9 MYD88 PMC3529804__F3 Novel Directions for Diabetes Mellitus Drug Discovery EPO MTOR SIRT1 PMC6880770__F6 Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways ACLY SPEN TH GAL INA PMVK MVD ACADL FOS PMC9590394__F1 T cell dysregulation in inflammatory diseases in ICU CASP9 IL7R CTLA4 LAG3 PMC10545798__F1 Landscape of cholesterol homeostasis regulation ABCG1 ACAT1 HMGCR LDLR ABCA1 PMC8716846__F6 Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury SYK MYB BAD GAL RBL2 PTEN CD19 MYC RHEB TSC2 BRCA1 BCR CD37 MEI1 MDM2 GRB2 PMC10545798__F6 Internal and external factor regulation of cholesterol metabolism PCSK9 ABCG1 HMGCR LDLR PTEN MTOR TNF ABCA1 MIEF2 PMC6372590__F5 PAK4 signaling in health and disease: defining the PAK4–CREB axis MC1R APC GSK3B CTNNB1 PMC10545798__F8 Cholesterol affects tumor cells by modulating immune responses, ferroptosis, tumor cell stemness, and the DNA damage response ZMYND8 STAT3 IPP HMGCR CD36 GPX4 LPCAT3 FDPS PMC4447120__F1 AMPK is a negative regulator of the Warburg effect in Fumarate hydratase-deficient kidney cancer KEAP1 HEL-S-133P PMC3852103__F2 Most significant GeneGO pathway map MAPK1 EGF RAF1 EGFR NCOA1 IRS1 MAPK3 HRAS TFF1 IGF1 PDPK1 NR3A2 ERBB2 GRB2 CCND1 PMC3213160__F3 Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling BCR IL3 EGFR EPO ATM IL7 IL5 PMC3151497__F3 MAPK signaling pathway MAX EGF SRI JUND FAS EGFR CD14 CR2 ATF2 TNF MYC FOS NGF RAD1 MOS NLK GCK PMC10286592__F3 Alteration of mTOR signalling pathway post TBI RHEB TSC1 ULK1 MTOR PMC4411872__F5 Genes involved in GPCR signaling Pathway: (G protein coupled-receptors are seven-transmemebrane receptors involved in signal transduction in humans) IL10 TGFB1 GNB3 BMP4 BMP2 EPO BMP7 NPY IL6 VEGFA TNF PMC10286592__F1 How TBI altered calcium dependent PLC pathways, oxygen species scavenging system and p53 signalling HMGB1 MYD88 PMC4411872__F7 Genes involved in chronic kidney failure (Disease Pathway) NR1i1 SLC12A3 REN GNB3 CCR2 IGFBP1 EPO NPY IL6 ENPP1 PMC4795462__F2 New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease ACLY FAS GLS PMC4795462__F1 New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease ACLY FAS HK2 PBRM1 BAP1 SETD2 PMC7456827__F1 Circadian regulation of complement immune system PER3 DBP PER2 HEL-S-62p C2 CRY2 CRY1 NFIL3 RORA PMC9511957__F6 Toll-like receptor 2 signaling pathway activation contributes to a highly efficient inflammatory response in Japanese encephalitis virus-infected mouse microglial cells by proteomics TRAF6 IRAK4 MYD88 PMC4200202__F7 Simplified interaction map between the LOXL4 protein with the OS pathway by both protein-protein interaction analysis and literature mining ECSIT DDR1 TGFB1 COL2A1 PKD1 LOXL4 BMP2 IGFBP7 EXOC6 CDC37 SUV39H1 NRF1 SIRT1 PMC8357146__F7 Regulatory mechanism of ASPN and DCN: We have proposed a Schematic illustration of the mechanism based on our conclusion SMAD2 SMAD4 PMC2829627__F3 PPARG agonists inhibit Stat3-mediated IL-6 gene expression in myeloma cells STAT3 TRO EBP PMC2829627__F2 Tumor-associated angiogenesis is sustained through stromal microenvironment crosstalk HGF IGF1 MIF PMC316768__F1 Model of somatic sex determination in C HSU53209 SDC1 SDC2 SDC3 PMC6621453__F3 siRNA screening identifies TrkB, TrkC, and FGFR1 DYRK1A FGFR1 MTOR PMC9488581__F1 Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review MUC5B TERT MPO PMC8949863__F3 Tug of War: Pseudorabies Virus and Host Antiviral Innate Immunity ISG20 STAT2 IFNAR2 IRF9 OASL ISG15 TYK2 PMC8949863__F2 Tug of War: Pseudorabies Virus and Host Antiviral Innate Immunity CGAS IRF3 IRF7 PMC8038663__F1 Chemical structure and mammalian glycosphingolipid (GSL) biosynthetic pathway UGCG B3GNT5 B4GALNT1 ST3GAL5 ST8SIA1 B4GALT5 A4GALT UGT8 PMC2956880__F4 Schematic diagram showing the interaction of the p75NTR and TrkB signaling pathways BAD BDNF APAF1 UNK PMC9266652__F3 Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer’s Disease NLRP3 NOD2 CRIP2 IL1B MYD88 PMC3822826__F2 Canonical Wnt/Beta-catenin signalling pathway APC GSK3B WNT1 TCF4 CTNNB1 PMC3494605__F1 A role for vimentin in Crohn disease ATG16L1 NFKB1 NOD2 PMC5000717__F2 The Hippo/YAP pathway is physiologically initiated via GPCRs LATS1 LATS2 PMC4024337__F4 NFKB gene signature predicts prostate cancer progression TRPS1 ITPKA RAB8A ARRB2 HMGCR F2 GDF15 XDH CCNB1 SRC PMC5919979__F4 Proliferation-associated lncRNAs act on at specific functional sites of the Wnt signaling pathway MMP7 HNRNPK CCND1 CTNNB1 PMC5919979__F2 Proliferation-associated lncRNAs act as p53 regulators or effectors by activating or inhibiting the p53 signaling pathway PMC5962695__F1 Extracellular matrix (ECM) in structural and functional synaptic plasticity DAB1 VLDLR SPARC PC MMP2 MMP3 PMC5919979__F5 Proliferation-associated lncRNAs act as MYC regulators or effectors by activating or inhibiting the MYC signaling pathway IGF2BP1 MTOR MYC CTNNB1 PMC3351275__F3 Negative feedback and adaptive resistance to the targeted therapy of cancer PTEN MTOR PMC8851069__F6 Advances in cGAS-STING Signaling Pathway and Diseases CGAS TREX1 DNASE2 PMC6773825__F2 Main strategies of immunomodulation CD27 CCR7 MTOR PMC9569803__F19 Glucogallin Attenuates the LPS-Induced Signaling in Macrophages and Protects Mice against Sepsis FAS NLRP3 TLR4 RELA TRAF6 MYD88 PMC3457170__F4 JAK/STAT signaling pathway is targeted by RVFV NSs protein at different levels EIF2AK4 EIF2S1 IF2B1 IFNA14 MAPK8IP3 IFNAR2 MED14 IRF9 RNASEL RAC1 PMC6487307__F12 Schematic summarizing the “reprogramming” of polyamine metabolism by iron-depletion in: (A) SK-Mel-28 human melanoma and (B) MCF-7 human breast cancer cells AMD1 SLC3A2 HEL-S-18 SMS SRM ELL SMOX PAOX ADI1 PMC5134922__F4 Ingenuity Pathway Analysis of the top overlapping networks in chronic beryllium disease and sarcoidosis BCL2L1 PTGER2 JUNB PIAS1 SOCS2 IRF1 IL2RA SOCS3 CISH TNF PMC3221743__F5 Working model describing how in HIV+ macrophages constitutively activated PI3K elicits blunting of lipid A-induced increases in TNFA release through sustained mTOR activation TLR4 MTOR MYD88 PMC3872233__F4 Toll-like receptor 4 signaling pathway in alcohol consumption TLR4 IRAK1 IRF3 IRAK4 MYD88 PMC9225917__F12 Huangqi Sanxian Decoction Inhibiting Osteoclast Differentiation Based on Network Pharmacology RHEB SYK MYB TSC2 BAD BCR TLR4 CD19 GRB2 MTOR MYC RAC1 PMC6526672__F2 Signalling pathways involved in glucose metabolism‐regulated NLRP3 inflammasome activation NLRP3 HIF1A SIRT2 EIF2AK2 PMC8387394__F3 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer ERCC1 STAT3 CXCL12 ITCH SOX10 CTNNB1 LATS1 BIRC5 LATS2 SOX9 DKK1 MMP2 HEL-S-66 SMO NOTCH3 SRC CIT CDH2 DDX5 FZD2 APC LRP5 SOX2 MMP9 ARHA SKI DRAXIN FOXD3 ADAM9 FOXO3A WWC1 PTCH1 ERBB2 ADAM10 CXCR4 GLI3 PMC5501640__F1 Sketch of Hedgehog (Hh) signaling pathway BOC SUFU GSK3B SMO GLI3 PMC8387394__F2 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer STAT3 WNT3A SMAD2 SASH1 PAX7 BAMBI HOXA1 POSTN SOX9 FOXQ1 SHH MMP2 ZEB2 MDM2 HES1 MSX2 PAX3 MMP7 IRS1 EPHB3 HAS2 GRB2 PTX3 EGF HOXB1 HMGA2 EGFR PTEN IGF1R CBX8 NODAL RHO MTOR RUNX2 TGFBR1 CTNNB1 TGFBR2 EEF2K MSX1 BMP4 UBAP2L TRPM7 E2F2 KRT14 LIF MMP9 RAC1 AXIN2 HAND2 IGF2 FGF2 GATA3 CD44 FOXD3 HMGA1 PDGFRA BMP2 ERBB2 JAK1 LEF1 PMC6126134__F1 Nuclear factor KB (NFKB) activation signaling pathways.Canonical NFKB pathway: the canonical pathway is inhibitor of KB (IKB) kinase (IKK)-dependent and IKB-dependent CD40 LTBR BCR RELB PMC5297776__F3 MTOR signaling pathway as a target of molecular therapies TSC2 TSC1 PTEN PMC8387394__F5 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer STAT3 FOXR2 FAS CCR2 GSK3B FAF1 HIF1A CERS6 BMI1 CCND2 AKAP4 SHH SMO ZEB2 HES1 CDK4 FOXE3 SOX2 PAX6 SATB1 S100P COL2A1 FOXD3 CRHR2 GLI3 PMC3213966__F3 Regulation of cardiac hypertrophy by AKAP complexes RYR2 HDAC5 RHO NFATC3 PMC8387394__F4 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer STAT3 MMP16 SMAD9 TGFB1 DMP1 SPARC SMAD4 PCOLCE NUMB DDR2 CTNNB1 BMI1 MFAP5 SOX9 ADAM17 MMP2 DMXL2 ATF4 HDAC6 HEL-S-15 SOX2 MMP9 ARHA ITGB3 ID1 FTH1 MAML1 FOXD3 ITGB1 BAG3 HMGA1 PEAR1 BCL2 KLK10 PMC6009094__F1 Wnt signalling pathway.Left: the Wnt pathway is activated by the interaction between LRP5/6, Wnt and Frizzled APC GSK3B LRP5 LRP6 PMC4437511__F4 Proteins from known pathways localized to the Trichomonas vaginalis hydrogensome FXN ISCU FES PMC3437941__F1 Integration of B cell responses through Toll-like receptors and antigen receptors BCR IRAK1 TRAF6 IRAK4 MYD88 PMC7753360__F2 Therapeutic targets and anticancer drugs within the lipid metabolism pathway ACLY LPL TG FAS HMGCR VLDLR CD36 SCD LDLR MTOR PMC7753360__F1 Lipid metabolism overview in normal and cancer cells ACLY LPL FAS HMGCR VLDLR LDLR PMC7847636__F3 Canonical Wnt signaling activates DPAGT1 expression and protein N-glycosylation, leading to extensive N-glycosylation of E-cadherin LRP5 CTHRC1 DPAGT1 PMC4894499__F3 Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury UGT1A1 BAAT SULT2A1 CYP3A4 PMC12111946__F3 Research Progress in Medical Biomaterials for Bone Infections BCR TLR4 MTOR PMC8076345__F3 Differentially Expressed Protein Interaction Network NAPA SYNJ1 WASF3 VAMP3 CYCS PCCA CYC1 SNAP91 ADD3 ATP6V1D CCAR1 VAMP1 HEL-S-26 ECHS1 DCC NAPB DNAJB1 FIS1 PGAM5 USO1 RPS19 CNTN1 MFF TSC2 PVALB PDHA1 DBN1 GCLC EIF3B RAB8B ACAD8 ATP6V1G1 RPS6KA2 TIMM44 GABBR1 ABAT HEL-S-128m PRKCSH AIMP2 LARS2 PA2G4 ANK2 HECTD1 ERLIN1 BIN1 PNPT1 HEL-S-70p ENTPD2 AKAP5 PADI2 ALDH7A1 RIN1 EPN1 SFRS5 NDUFB6 RAB5C PSMD12 DCTN4 GNG5 PTPRF HERC2 PPFIA2 MARS2 VWA1 GADD45GIP1 NECAP1 RAB3GAP2 HSPA2 SAMM50 SNRPB ACADVL SRC CYLD ARFGAP2 ASB14 HMGN2 VTI1A HEL-S-2 MRPS2 MRPL14 LDHB PDPR EIF4E ME3 ARHGAP5 EIF3G CDK5 ELMO1 ME2 PAK1 VARS2 CAPZB WASF1 ALDH3B1 HEL-75 SPTB HEL107 UFL1 NRCAM PJA2 IMMT RAB6B RBCK1 AMPD2 PTEN NDUFS8 GANAB KHDRBS1 VCP ADD1 RPS13 TRIM9 YKT6 CALB1 NDUFB7 CACNB3 CDH10 PDIA4 EIF4B SNRPG MIA3 HMGN1 APOA2 CACNA2D1 SIRPA DNAJB11 RRAS NDUFA2 PFKL PFAS PMC7490904__F1 Physiological functions and regulation of the cyclin D-CDK4/6 complex TSC2 CDK6 CDK2 CDK4 PMC5468232__F12 ARF/p53 pathway RFWD2 TSC2 ATR PERP CASP3 ATM PTEN MDM2 MYC PMC5468232__F11 Estrogen signaling pathway TF CCIN SHE DAO PMC6080523__F4 Graphic scheme of pathways shared by genes found in network analysis for progressive motility PMC8615680__F1 Genetic Determinants of Plasma Low-Density Lipoprotein Cholesterol Levels: Monogenicity, Polygenicity, and “Missing” Heritability NPC1 MYLIP ABCA1 PCSK9 LIPA LPA LIPC OSBPL7 MTTP CYP7A1 NPC1L1 PPP1R3B LDLR CAP1 LPL ABCB11 APOE SLC22A1 NPC2 LRPAP1 ABCG8 SORT1 HMGCR ABCG5 ANGPTL3 SAR1B GCKR HNF1A PMC7922891__F7 Hereditary disorder, metabolic disease, organismal injury and abnormalities network affected in lymphoblastoid cells derived from an SS patient DTD2 DCXR DENND1C FAM50A NAA25 BRWD1 TAS2R20 PRKRIP1 ZNF431 PCIF1 QTMAN GIMAP6 FMNL3 DTWD1 TCP11L2 SP140L PMC7922891__F6 Graphical summary of human skin fibroblast profiling of SS patients OLR1 TICAM1 BMP4 BMP2 IL36G GNA13 PMC7118069__F1 Major signaling pathways for protective mechanisms against ASD by SF KEAP1 COX2 HSF1 TNF PMC8185703__F1 LZTR1: A promising adaptor of the CUL3 family SHOC2 F2 PMC12009291__F1 Glucose metabolism and lipid metabolism reprogramming in RCC DEPDC1 MLYCD ECHS1 PFKFB4 FBP1 HEL-S-5 UQCRH EZH2 TRIM21 PMC8185703__F2 LZTR1: A promising adaptor of the CUL3 family HRAS NF1 RIT1 RRAS KRAS PMC5911514__F2 Primary Cilia as a Signaling Platform for Control of Energy Metabolism SUFU APC SMO CTNNB1 PMC5361837__F4 Examples of functional networks of regulated genes shared by different tissues RPL39L PON3 RPL3L TRIO NTN1 SFXN4 ALKBH3 SMYD3 SLC35B2 PLA2G12A CLN3 DST MRPL9 CTSC CAPNS1 SLCO2B1 RAB35 RPL14 PSAP OPTN PMC7718646__F1 miRNA-23a can enhance the metastasis and invasion of OS cells by upregulating the signal expression of PTEN signaling pathway EGF BAD EGFR PRMT9 ZNRF3 PTEN MTOR PMC8531546__F2 Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage SPHK1 NFATC3 TNF RAC1 PMC11263586__F5 HPV perturbs DNA damage response signalling pathway HUS1 TOPBP1 ATR RAD50 ATRIP RAD51 H2AX RAD17 ATM MDC1 PMC2699967__F2 Signaling pathways initiated by TLR-2 and TLR-4 activation TBK1 MAL CD14 IRAK1 TRAF6 MYD88 PMC6349186__F4 Wnt signalling pathway uniquely identified by ce‐Subpathway SIAH1 ROCK2 APC FBXW11 SMAD4 CYC1 ARHA BAMBI TCF7L2 SOST INVS CER1 SKP1 EP300 NLK LEF1 PMC6349186__F5 MI‐related subpathways where key nodes are annotated CDC42 BAX BAD VASP FRS2 HEL-S-28 PTEN ARHA SHE IRS1 CRK NGF GRB2 SRC BDNF PMC4094786__F4 Metabolic pathways for the production of the high-value products by using Z HEL-S-133P HBD SDHC PMC3647990__F9 Model for Rrp1 regulation of chitobiose metabolism in B RRP1 MAL PMC4659440__F5 c-Met as a Target for Personalized Therapy EGF HGF EGFR VGF MTOR PMC4659440__F3 HGF-MET signaling pathway with its downstream effector components (MAPK, STAT, PI3K-AKT cascades and NFKB) leading to increases in cell survival, motility and proliferation BAD HGF GSK3B BCL2 MDM2 MTOR PMC9267302__F6 Investigation of the Molecular Mechanisms Underlying the Antiatherogenic Actions of Kaempferol in Human THP-1 Macrophages PIK3CA JUN PRKD1 LIF MYOCD ATF2 PTGS2 RPS8 GNAS MAP2K4 NPPA MAPK7 MAP3K7 HEL-S-11 NPPB PMC6824625__F9 Hypothetical schematic model for a novel oncogenic mechanism of G0S2 LATS1 MMP2 G0S2 IL6 MMP9 SRC YAP1 CTNNB1 PMC3346111__F7 Overall scheme of hypothetical effect of endocannabinoid signaling in human melanocytes MC1R POMC TRPV1 PMC4828651__F4 Transcriptome Variability in Keratocystic Odontogenic Tumor Suggests Distinct Molecular Subtypes ADRBK1 HHIP ARRB2 SUFU SHH PMC9679292__F3 New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke TF STEAP3 GPX4 DMP1 LPCAT3 MAF FACL4 SLC7A11 ATF4 ADA PMC5423227__F1 Alterations in DNA methylation patterns as a source of cancer progression traits CYTIP CTCF PDGFRA BCL2 VEGFA HEL-S-26 VHL PMC9679292__F2 New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke GLS FER GPX4 LPCAT3 CTH FACL4 HEL-S-64p HEL-75 ADA PMC3944322__F1 Parkinson's Disease Gene Therapy: Success by Design Meets Failure by Efficacy TH GDNF NRTN PMC5827560__F1 A biological pathway regulating memory, synaptic plasticity and schizophrenia risk NRG1 ERBB4 NAB2 ARC NFATC3 BDNF PMC6567807__F1 Curcumin modulates cancer progression by controlling diverse signal transduction pathways STAT3 BAX BAD GSK3B MTOR UNK CTNNB1 PMC3328216__F1 CCM3 interacts with multiple signaling complexes ROCK2 ROCK1 ARHA UNK PMC7464343__F2 The mechanisms and cell fate decisions’ crosstalk underlying necroptosis induction RIPK3 MAP3K7IP1 TRADD MLKL TRAF5 RIPK1 TNF CYLD TRAF2 UNK FADD PMC5593197__F6 Equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila SMAD1 JUN RALA SMAD4 PMC8075731__F7 HGF/c-Met signaling regulates early differentiation of placental trophoblast cells HGF CP PMC7761504__F1 Wnt signalling pathways CDC42 JUN DKK1 APC LRP5 LRP6 RYK ARHA DAAM1 CTNNB1 PMC11432004__F4 PI3K/Akt/mTOR signaling pathway by O-GlcNAcylation OGT TSC2 FASN PTEN IRS1 PMC11432004__F3 Pathways associated with O-GlcNAcylation, thrombosis, inflammation, and cancer FLT3 EGF HGF TGFA EGFR FLT3LG PTEN MTOR KITLG ERBB2 GRB2 CCND1 CDK4 PMC8860906__F1 Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review NAPA FOXO4 ATG12 SMO BCL6 FOS CTNNB1 PMC7379337__F7 Schematic illustrating the mechanisms involved in the protection of hyperoside against oxidative liver stress FYN PHLPP2 GSK3B PMC3956533__F7 Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells TSC2 EIF4B TSC1 PMC6909929__F1 Proposed model of myostatin-induced skeletal muscle wasting and insulin resistanceMyostatin binds to it’s receptor (ActR2B), phosphorylating the Smad2/3 pathway IGF1 SMAD2 SMAD4 MTOR IRS1 PMC5064167__F1 Upstream and downstream mechanisms of the ERK5 signaling cascade in DRG neuronsDashed lines indicate the need for further examination of possible signaling or the mechanism, which is complicated and abbreviated in this text NGF SRC BDNF MEF2C PMC3059306__F1 TSC mediated signaling in the central nervous system RHEB MLST8 TSC2 RICTOR MTOR PMC6548990__F2 TNFR1 signaling RIPK3 CASP8 TRADD MLKL RIPK1 TRAF2 FADD PMC6548990__F4 Cytotoxic TLR-TNF signaling network CASP8 MLKL TRAF3 TNF MYD88 RIPK3 TLR3 TLR4 RELA RIPK1 TRAF2 CYLD IL1B FADD PMC6548990__F3 TNFR2 signaling TRAF1 TRAF3 PMC6548990__F5 Type I interferons in the cytotoxic TLR-TNF signaling network TBK1 STAT2 MLKL IRF9 TANK IRF1 IRF3 TRAF3 TNF MYD88 RIPK3 STAT1 TLR3 IFNAR2 TLR4 RELA IFNAR1 RIPK1 JAK1 TYK2 PMC8377849__F10 Pitx controls amphioxus asymmetric morphogenesis by promoting left-side development and repressing right-side formation PROP1 LHX3 NODAL PMC3133224__F9 Molecular interplay between FBXL2, its substrate CCTA, and CaM controls phosphatidylcholine (PC) synthesis UBC SKP1 PMC6787465__F1 Schematic outline of major Btk signalling cascades SYK MAL BLNK IRF3 CD19 TRAF6 MYD88 BTK NLRP3 TLR3 BCR PLCG2 IL16 LYN BIK PMC5063375__F4 Fuzzy Decision Making Approach to Identify Optimum Enzyme Targets and Drug Dosage for Remedying Presynaptic Dopamine Deficiency TH MIF PMC9623986__F3 Personalized targeted therapy prescription in colorectal cancer using algorithmic analysis of RNA sequencing data TCF20 TP73 UBE4B RASSF1 ITCH BRCA2 BRAF CCNA2 PLK1 PIN1 MAPK3 MAPK14 CIDEA WWOX PALB2 MAPK1 CDC2 RAD52 KRAS ARAF HRAS CCNE2 CDK5 PLK3 CHEK1 DAPK2 CDK2 FGFR3 EP300 MAP2K1 MAP2K2 RPS6KA5 RCHY1 PMC3494587__F12 Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes EIF2AK4 EIF2S1 ATG12 EDEM1 PI3 BCL2 ATF4 MAPK8 XBP1 PMC4332478__F3 Integrative Multi-omics Module Network Inference with Lemon-Tree EGFR PTEN CCM1 CDKN2B RB1 MDM4 CDKN2A CCNE1 KLLN INSR PDGFRA FGFR3 MDM2 CDK4 PMC7388972__F5 Schematic representation of S. pombe cell wall integrity pathway PCK2 ATF1 PCK1 PMC6129528__F4 Regulation of cell signaling pathways involved in cancers by KDM2B EZH2 MTOR CTNNB1 PMC6129528__F6 Overview of KDM2B mediated molecular mechanisms in cancer development NSG2 KDM5A MYC PMC10898159__F3 Mechanism of action of existing drugs targeting KIT expression and mutations BRD4 CBL CDK7 SP1 PTCH2 AMPD3 PTCH1 KIT FGFR3 SMO FGF2 PMC4145906__F3 The role of mitochondria in Parkinson's disease TFAM LRRK2 POLG PMC7513951__F3 MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment GSK3B TCF4 MYC CCND1 PMC5596544__F8 Schematic of the AcSDKP/FGFR1/MAP4K4 pathway suppression of TGFB/smad signaling and EndMT HEL-S-31 TGFBR2 FRS2 FGFR1 TGFBR1 PMC9338018__F1 MiR-30a-centered molecular crosstalk regulates Th17 differentiation INPP4B TLR4 RELA IL21R PMC7513951__F2 MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment EGFR GRB2 MTOR SRC PMC11641392__F2 Notch signaling pathway with Notch and Bcl-2 therapeutic targets in T-ALL BAD BCL2A1 MCL1 PTMS ADAM10 FURIN PMC7158685__F1 Main immunological pathways in human antigen presenting cells (APCs) after mycobacterial RNA recognition IFNG TLR3 APC TLR8 IRF3 IL1B MYD88 PMC4052302__F10 General overview of TLR4 signaling in humans TLR4 MAL TANK IRF3 TRAF3 TRAF6 IRAK4 MYD88 PMC4300671__F1 Working model for rotavirus cell entry into MA104 cells CDC42 ACTN4 ARHA EEA1 M6PR PMC5796392__F6 Role of miRNA in the antigen cross presentation pathway HEL-S-72p STAT1 PSMB8 HEL-S-269 PSMB10 PMC11223907__F1 Cyclophosphamide Pharmacogenomic Variation in Cancer Treatment and Its Effect on Bioactivation and Pharmacokinetics CYP2C19 CYP2C9 CYP3A4 PMC5613881__F2 Regulation and signaling crosstalk of the Hippo pathway LATS1 LATS2 APC RHO CTNNB1 PMC10898159__F2 Regulations in KIT protein and signaling pathway LMTK3 LIX1 PTCH2 AMPD3 PTCH1 KIT FGFR3 SMO FGF2 PMC10898159__F1 Gene and epigenetic regulations of KIT expression in GIST BRD4 BIRC5 CTCF HIC1 FOXF1 KIT HAND1 PMC3430207__F3 Molecular relational network of genes modulated by BaP in lung tissues enriched for cancer function using IPA for all three doses with p53 at the central node EPHA2 PLK2 PMAIP1 MYC BCL2L1 SHH MMP3 MDM2 DCN SAA1 TNFRSF12A LMO2 TP53INP1 PERP PLAUR ANGPT2 LTB EPX CCL24 CDKN1A FBLN5 LAMB3 LCN2 AKAP12 BDNF ACTG2 HEL-S-31 IGFBP2 CDKN2B INS PRKCH TPM1 CCNG1 F3 HEL-S-14 GDF15 CCND1 IL1B BAX HEL-S-101 PDGFD LTC4S CFD RRM1 IL1RL1 HEL-S-89n BLNK HMGN1 CD47 KITLG RHOU PLCE1 ITGA1 IGFBP5 PDGFRA RELA CD200 TNFSF10 PMC5613881__F1 A brief summary of the intracellular Hippo pathway in mammals LATS1 LATS2 PMC8909069__F3 Biomarkers in FLT3 AML GRB2 MTOR PMC6952906__F2 Schemes of feedforward loops (FFLs) TF RB1 PPARG EGR1 SCAMP3 IL6 PMC7395767__F1 Old dogs, new trick: classic cancer therapies activate cGAS TBK1 CGAS IRF3 PMC6462526__F6 5′-IT treatment affects intra-/extracellular adenosine balance and INSM1 expression leading to NB tumor cell death INSM1 ADK GSK3B CCND1 CTNNB1 ADA PMC4556939__F4 Transcriptomic analysis of cyclic AMP response in bovine cumulus cells STAT3 PTX3 NOS2 CCK STAR PGR HIF1A MMP9 VEGFA PCK1 VCAN FGFR2 MAP3K8 PLAT CDKN1A PDGFRA FGFR1 LDLR HAS2 GJA1 SMARCA4 YWHAG PMC4556939__F7 Proposed pathway of cAMP signaling after FID addition during in vitro maturation STAR CCK HK2 EGFR HAS2 AREG PMC5503519__F9 Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells CCND3 IL13RA1 JAK1 GATA3 PMC9573978__F2 Emerging roles for IL-25 and IL-33 in colorectal cancer tumorigenesis APC GSK3B LRP5 LRP6 CTNNB1 PMC4199747__F6 PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status STAT3 DAPK2 CIDEC PMC3547332__F5 MicroRNA involvement in the inflammation, innate immunity, and oxidative stress pathways in AD and cancer CFH IRAK1 IRAK2 TRAF6 PMC3481480__F11 Pathway Diagram of Oxidative Stress along with PI3k/Akt BAD BACH1 KEAP1 GSK3B MAF ATM PTEN MDM2 PMC8255023__F4 Aberrantly methylated-differentially genes and pathways among Iranian patients with colorectal cancer BAMBI SOST INVS STOM APC NOTUM LRP5 LRP6 SKP1 ARHA NLK PMC6354055__F1 Mutation Hotspots in the Beta-Catenin Gene: Lessons from the Human Cancer Genome Databases APC GSK3B LEF1 CTNNB1 PMC9550596__F5 Henipaviruses: an expanding global public health concern? STAT1 MAVS TRIM25 TLR3 STAT2 IFNAR1 TLR8 IRF3 IRF7 TLR7 PMC6305535__F5 Representation illustrating the interactions of Fusobacterium nucleatum in colorectal cancer TLR4 IL1B CTNNB1 MYD88 PMC4687939__F6 Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism KLF3 LEP TXNIP EBP HIF1A SETDB1 XBP1 CTNNB1 FBXW7 CTBP2 SOX9 FOXC2 RBP1 PLIN1 MNAT1 CTBP1 MSC ATG5 CEBPB LPL NFATC4 BSCL2 PER2 FABP4 BMP2 LPIN1 KLF5 EGR2 PMC7092482__F1 Epigenetic modulation of noncoding RNAs regulate cancer biology AGO2 EGFR ALKBH5 SOX2 PMC8817562__F1 Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy STAT3 APC GSK3B CTNNB1 PMC7590900__F1 CXCR3 signaling pathways in different cell types CXCL9 CXCL11 CXCR3 CAD INA DERA CXCL10 PMC4267650__F6 The roles of the RuvBL1-RuvBL2 complex in regulating the FA DNA repair pathway TRRAP ATR SMG1 ID2 RUVBL1 RUVBL2 ATM MTOR PMC6964678__F3 Lipid metabolism by PI3K–mTOR signalling ACLY RHEB ACSS2 TSC2 FBXW7 TSC1 SGK1 NADK FASN GSK3B SRPK2 PTEN PMC6964678__F2 Cancer cells obtain fatty acids (FAs) from de novo lipogenesis and exogenous uptake ACLY ACSS2 FAS CD36 SCD FADS2 GLS2 HEL-S-26 PMC3694595__F1 IL-33: A Novel Danger Signal System in Atopic Dermatitis IL25 TSLP IL33 PMC4918232__F2 B cell receptor pathway in chronic lymphocytic leukemia: specific role of CC-292 SYK CD79A BTK BCR LYN MTOR PMC4918232__F1 Antigenic stimulation of the BCR recruits CD79a and CD79b, and activates SYK and LYN kinase, resulting in the phosphorylation of cytoplasmic ITAMs on the immunoglobulin domains of the receptor SYK BTK BCR CCL3 CCL4 LYN MTOR PMC4929790__F2A Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy MGST3 HIVEP1 TXNIP CTSS ARC MPO CYTIP TREM2 CSF2RB LOX CEBPD F3 PRSS2 GBP2 THBS1 RPSA IRF1 ANXA1 FABP4 IRF7 TNF ANGPT2 FOS NCOR2 ARHGDIB NFKBIA IL8RB VCAM1 LCN2 PMC2824626__F1 Pathway for cholesterol synthesis from 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) by HMG CoA reductase and its inhibition by statins CDC42 BMP2 ARHA RAC1 PMC5577206__F2 Vascular endothelial growth factor-B in metabolic homoeostasis: current evidence VEGFB FAS NRP1 VEGFA PMC4598984__F1 Data analysis of the identified Snf1 interactors RPL3 CPA2 tal-1 PMC11871796__F2 The possible mechanism leading to Tourette syndrome (TS) associated with the immune response/inflammation STAT3 IL6 TNF PMC11871796__F1 Microglia M1 polarization–mediated tic onset TH HMOX1 NLRP1 CCR5 PITX3 SOCS3 CCL5 MYC CCL2 CCR1 PMC3661948__F2 Receptor-mediated regulation of KATP channels INSR LEPR MC4R PMC5078009__F4 Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells EPCAM SOX2 MTOR PMC12162393__F9 Diagram of potential mechanism of TPX2 in HCC MTOR HCTP4 PMC7485276__F2 Illustration of selective components in the BMP signaling pathway, important for bone and cartilage formation and fracture healing SMAD1 DKFZp781O1323 SMAD4 PMC4523214__F1 Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma SYK BTK BCR PLCG2 GSK3B CD19 PTEN LYN MDM2 MTOR PMC7846844__F8 LincRNAs involvement in muscle fiber hypertrophy signaling by regulating its target genes IGF1 PC MCU IGF1R IGF2 PMC8946552__F2 Ferric Nitrilotriacetate in Renal Carcinogenesis and Cell Death: From Animal Models to Clinical Implications HGF KEAP1 EGFR EPO PTEN FLCN CDKN2B HMOX1 CDKN2A CDK6 PBRM1 FNIP1 CDK4 FH BAP1 SDHD RHEB SDHA TSC2 SDHB RBX1 TSC1 FNIP2 TFEB FES SDHC PMC8946552__F4 Ferric Nitrilotriacetate in Renal Carcinogenesis and Cell Death: From Animal Models to Clinical Implications GPX4 DHFR LPCAT3 FACL4 PMC9214809__F8 Selective PPARD agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway CYP7A1 FGF21 NR1C2 PMC11868049__F2 Downstream effects of the ubiquitination process in the cGAS-STING pathway TRIM13 BAX TBK1 CGAS IRF3 USP21 TRAF6 PMC11868049__F1 Ubiquitination in cellular processes of cGAS-STING Pathway TBK1 CGAS SPSB3 TRIM41 IRF3 USP21 PMC7080318__F7 LINE-1-induced replication stress FANCD2 HUS1 ATR ATRIP RAD1 PCNA WRN RFWD3 BLM RADX PMC7352172__F2 Activation of the NMRK2 pathway represent a common adaptive mechanism in the failing heart where NAD+ levels are low NR1C1 NAMPT NMRK2 PMC7352172__F1 NAD+synthesis pathways NRK NAMPT PMC8122392__F2 Context-Dependent Impact of Integrin-Associated CD151 and Other Tetraspanins on Cancer Development and Progression: A Class of Versatile Mediators of Cellular Function and Signaling, Tumorigenesis and Metastasis MYB CD36 APC CD82 RELA CD151 LRP5 LRP6 MYC CCND1 CTNNB1 PMC4698020__F8 Schematic diagram showing the inhibitory effects of triptolide on oxaliplatin induced upregulation of nucleotide excision repair pathway ERCC1 XPA XPC PMC5882534__F2 Optogenetically controlled protein kinases for regulation of cellular signaling BAX BAD PMC7418174__F1 Diagram showing mTORC1 and mTORC2 signaling pathways RHEB RPS6 TSC2 TSC1 ULK1 TFEB DEPTOR IRS1 PMC9279477__F2 Calculated excited states of Pd-DPAphos complexes and synthesis of DPAsphox (1) SOS1 SOS2 SET PMC5826840__F8 Myeloid Notch1 Deficiency Activates RhoA/ROCK Pathway And Aggravates Hepatocellular Damage In Mouse Ischemic Livers TLR4 ROCK1 CASP3 PTEN TRAF6 HES1 UNK NOTCH1 MYD88 PMC11694134__F4 RAS pathway activation and downstream effects in chronic myelomonocytic leukemia CDC2 AURKA SOS1 PTPN11 PLK1 RHEB TSC2 CBL TSC1 CDK6 NF1 SOS2 WEE1 GRB2 CCND1 CDK4 PMC11694134__F5 Additional established and investigational therapeutic targets in chronic myelomonocytic leukemia TET2 BRD4 NLRP3 HOXA9 LILRB4 PDC BCL2 IL1B PMC9325157__F2 Coronaviral Infection and Interferon Response: The Virus-Host Arms Race and COVID-19 TBK1 MAVS STAT2 IRF9 TANK STAT1 TLR3 TLR4 TLR8 TLR7 JAK1 TYK2 ACE2 PMC7555177__F5 Sphingolipid signaling pathway and sphingolipid metabolism UGCG PIK3R2 SPHK1 PIK3R1 PRKCZ PTEN RHO FYN SGPP1 NSMAF PRKCA GLB1 BAX CERK ROCK2 GBA2 TNF S1PR4 S1PR1 S1PR3 HEL-S-130P GNA11 CER1 MAP2K1 ACER3 GAB2 BDKRB2 PMC7555177__F4 Protein–protein interaction networks of the encoded proteins of the consistent DEGs that participate in sphingolipid signaling pathway (hsa04071) and sphingolipid metabolism (hsa00600) PIK3CA RAF1 SGMS1 PIK3CD PIK3R2 PIK3R1 PRKCZ SMPD1 SMPD2 SMPD4 SPTLC2 FYN PDPK1 PRKCA GLB1 MAPK1 PPP2R2C MS4A2 ROCK2 GBA2 HRAS PLCB1 BCL2 BDKRB2 UGCG MAPK11 SGPL1 PIK3R3 AKT3 SPHK1 PTEN DEGS2 PPP2R5C PPP2R3C RAC3 PRKCE S1PR2 NSMAF SGPP1 ROCK1 BAX CERK PLD2 PPP2R5B GLA HEL-S-130P PPP2R2A SPTLC1 MAP2K1 ACER3 PMC8569372__F6 Alternative splicing in human cancer progression PTBP1 NEK2 PMC6959052__F7 Working model of the role of IL-6/STAT3 pathway on hypoxia promoting HCC progression after TACE STAT3 SNAI1 ELL PMC8699390__F3 Of E3 Ubiquitin Ligases in Cancer Immunity: Opportunities and Challenges TRIM13 TRIM14 TRIM5 TRIM38 TRIM32 TRIM56 ITCH RELB TRAF6 TRIM21 TRIM25 TRIM37 TRIM52 TRIM8 TRIM6 TRIM4 TRIM23 PMC3656004__F11 Acetylcholine Promotes Ca2+and NO-Oscillations in Adipocytes Implicating Ca2+→NO→cGMP→cADP-ribose→Ca2+ Positive Feedback Loop - Modulatory Effects of Norepinephrine and Atrial Natriuretic Peptide PTEN TRPC6 TRPC3 PMC3348393__F1 Cellular Senescence and Cancer Chemotherapy Resistance ATR BRCA1 H2AX ATM MDC1 PMC8621778__F1 Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases VANGL1 APC GSK3B LRP5 LRP6 RYK ARHA DAAM1 CTNNB1 PMC9688300__F1 O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease OGA OGT FAS CRTC2 PCK1 PMC7103590__F8 Expression profiles and prognostic significance of WNT family members in glioma via bioinformatic analysis EGF SIAH1 ROCK2 APC ELL SMAD4 RYK PTEN MTOR ARHA SHE BAMBI SOST INVS CER1 SKP1 NLK MDM2 PMC9688300__F3 O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease RIPK3 TFF2 OGT XBP1 PMC9688300__F2 O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease GSK3B IRS1 PMC2584165__F2 Highly simplified diagram of signaling pathways involving Beta-catenin that may be relevant for RPE cell morphogenesis and susceptibility to age-related oxidative stress CDH2 APC LRP5 LRP6 TYRP1 CTNNB1 PMC8781927__F6 FGFC1 Exhibits Anti-Cancer Activity via Inhibiting NFKB Signaling Pathway in EGFR-Mutant NSCLC Cells TNF CCND1 CDK4 PMC7317222__F6 Cholesterol-oxysterol metabolic pathway TH CH25H CYP46A1 PMC1297683__F3 Final network resulting from applications of our integration method to the 18 types of evidence for yeast galactose utilization and a set of network analysis tools MALL LAP3 PMC2746948__F1 Apoptosis pathway FAS APAF1 FADD PMC6235681__F2 Details of the SHH and Akt pathways PAWR SUFU PTCH1 SHH SMO MTOR PMC3184252__F6 Pathways of androgen biosynthesis HSD17B3 CYP17A1 HSD17B2 HSD17B10 RDH5 AKR1C2 STS PMC6208163__F6 The Roles of NRF2 in Modulating Cellular Iron Homeostasis HMOX1 FTH1 FTL GPX4 MAF MT1G SLC7A11 PMC2212135__F6 Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2 PRLR IGF2R UCP1 IGF1R IGF2 PMC7135884__F3 Metabolic adaptations after phagocytosis and inflammatory stimulation in macrophages and microglia IL16 MTOR IL1B PMC6208163__F2 Roles of NRF2 in Modulating Cellular Iron Homeostasis ABCB6 MAF FECH PMC10779880__F4 Mechanisms of treatment of neurodegenerative diseases (NDs) using capsaicin and N-oleoyldopamin (OLDA) CNTF TRPV1 MTOR FAAH PMC4179759__F1 Melanoma signaling pathway BRAF NRAS PTEN PMC7477441__F7 Mechanism of LINC00355:8 in HCC WNT10B CDH2 CTNNB1 PMC3797167__F7 Illustration of the proposed mechanisms underlying the crosstalk between insulin/IGF1 and IL-17 signaling pathways IL17RC IGF1 CXCL1 GSK3B TRAF5 TRAF6 CCL20 TRAF2 PMC6874469__F5 ERB/Ptgds signalling pathway imbalance disrupting renal lipid metabolism and continues influencing ‘hypothalamus-uterus-kidney axis’ (HUK axis) function AMBP PMC5419340__F2 Diet supplies nicotinamide, nicotinic acid, and nicotinamide riboside as well as the essential amino acid tryptophan NNMT NAPRT NAMPT PMC5916231__F1 Heme synthesis pathway HMBS CPOX AIP FECH UROS PMC6557297__F4 Possible replication-coupled ICL repair mechanisms NEIL3 TRAIP FANCM BLM PMC2600462__F5 Morphoproteomic Evidence of Constitutively Activated and Overexpressed mTOR Pathway in Cervical Squamous Carcinoma and High Grade Squamous Intraepithelial Lesions RHEB TSC2 EGFR MTOR SKP2 EIF4E PMC11615404__F10 Fisetin on ferroptosis and oxidative stress in glutamate- and erastin-stimulated HT22 cells and rats after TBI, which may involve the PI3K/AKT/NRF2 pathway SLC3A2 FTL STEAP3 GPX4 PMC3097389__F1 CoQ10 biosynthesis pathway COQ7 PDSS1 COQ3 COQ2 COQ6 COQ5 PMC3497051__F4 Autophagy process ATG10 ATG3 ATG12 ULK1 MTOR ATG5 PMC8570279__F1 Transcriptional Control of Metastasis by Integrated Stress Response Signaling ATF3 KEAP1 ATF4 EIF2A PMC2820251__F1 Innate immune evasion strategies of influenza viruses TBK1 MAVS TRIM25 TANK IRF3 TRAF3 TRAF6 PMC9252739__F1 Shiny GATOM: omics-based identification of regulated metabolic modules in atom transition networks ACLY OXCT1 HEL107 MGST3 KHK ASS1 HEL60 GOT2 RRM1 NAMPT HEL-S-30 ENPP1 PNPLA7 MECR PGAM1 RPIA SUCLG2 pcap ENO1 UMPS HEL-S-26 HEL-S-64p PMC5095918__F5 LUBAC and UBE2L3 regulate NFKB response SHARPIN TNF UBE2L3 IL1B PMC7483931__F1 Periodontal disease associated genes and proteins have multiple possible interactions with GM-CSF and TSLP POSTN CXCL12 DGKA TNFSF13 TNLG7A PTGS2 ODAM HYAL3 HYAL4 PMC7917312__F2 Armed oHSVs for GBM treatment IFNG ULBP3 KLRG1 EIF2A PMC3445623__F2 Gene Expression and Functional Annotation of the Human Ciliary Body Epithelia HDAC3 PELP1 PGR GRIP1 IGFBP1 GRB2 NR0B2 TBP SRC PMC4866511__F7 Endosomal System Genetics and Autism Spectrum Disorders: A Literature Review RHEB TSC2 TSC1 PTEN PMC7923825__F1 Engineered (S)-linalool biosynthetic pathway in P IPP MVD MVK PMC6032036__F4 Ingenuity pathway analysis of ALX4 genes and antidepressant genes based on treatment response in MDD GAS7 CYP2E1 ALX4 IL5RA PLG HTR2A MYC CTNNB1 TPH1 CYP7A1 EXT2 CYP2U1 CYP2C9 BDNF LEF1 CYP4F12 PMC7363449__F1 Acute Kidney Injury and Maladaptive Tubular Repair Leading to Renal Fibrosis ATR RIPK1 MYD88 PMC4673612__F6 Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks EGF JUND PXN WASL RFXANK CTNND1 ASAP1 BRAF PRKCZ FLOT2 SH2D2A MYC MAPK14 RALB RALA PDPK1 PRKCA HEL-S-1 SH3GL3 CEBPB SP1 TNP1 HRAS SPRY2 HDAC1 PLCE1 GRB7 CEBPA PRKCI NFKB1 RELA EPN1 PEAR1 SH3GL2 RPS6KA3 JAK1 GJA1 YWHAZ PMC8870348__F3 Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy DCC DHODH NDP PMC4673612__F4 Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks JUND SOS1 COPS5 ANAPC2 ATF2 TGIF1 TRAF6 MEF2C CTNNB1 MAPK14 BTRC ROCK1 STAMBPL1 CCND1 MAP2K3 NR1i1 FOSB ARRB2 JUNB TGFBR3 ARHA SKI FNTA CD44 HGS CRK ATF3 NR2A1 SMURF1 PARD3 BRCA1 CREBBP GRB2 UBE2I SMURF2 PRKAR1B PMC4673612__F7 Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks WNT3A PPP2CA RYK TCF4 PIN1 PRKCB CTNNB1 BTRC CDK6 CSNK1E DKK1 SOX1 WNT7A PRKCA WNT1 WNT4 CSNK1A1 CCND1 DIXDC1 CDH2 JUP ARRB2 APC ROR2 HEL-S-28 ARHA RAC1 AXIN2 FZD4 WNT3 DAAM1 PMC11830176__F1 HBME inhibit LPS activated canonical NF-kB pathway in microglia and its effectors NLRP3 TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC4911209__F1 Complete vs ZEB2 PMC5095918__F2 The Fanconi anaemia pathway REV1 F10 BRCA2 PMC2820251__F2 Innate immune evasion strategies of influenza viruses STAT1 STAT2 ISG15 JAK1 TYK2 PMC3337981__F8 BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NFKB pathway CD40 BCL10 BCR RELB TRAF3 TRAF6 TRAF2 AID MYD88 PMC5559228__F4 Control of B Lymphocyte Development and Functions by the mTOR Signaling Pathways MTOR PREB FNIP1 PMC7554788__F1 Action of CDK4/6 inhibitors CDK6 MTOR CDK4 PMC5727316__F1 lncRNAs in Wnt/B‐catenin signalling GSK3A APC CTNNB1 PMC5559228__F2 Control of B Lymphocyte Development and Functions by the mTOR Signaling Pathways SYK ULK1 PTEN CD19 MTOR RHEB TSC2 BTK RICTOR TSC1 FNIP2 LYN GRB2 FNIP1 PMC4263855__F3 Potential protective role of O-GlcNAcylation within the healthy brain, which may become deficient in the AD brain OGA OGT APP PMC10304117__F1 ASFV proteins modulating the cGAS/STING and NFKB signaling pathway (Created with BioRender RNF128 TBK1 CGAS IRF9 IRF3 PMC9243614__F3 Differential miRNA expression profiling of highly pathogenic avian influenza virus H5N1 infected chicken lungs reveals critical microRNAs, biological pathways and genes involved in the molecular pathogenesis IGF1 IGFBP5 NFKB1 IKBKB NFKBIA IGFBP1 CHUK IGFBP4 IGF1R REL IL1B PMC6415732__F2 Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities ATG101 RHEB BAX OMP ULK1 ATM PMC5115891__F3 Comprehensive transcriptomic analysis of differentiating embryonic stem cells in response to the overexpression of Mesogenin 1 JUN MTOR HES7 HES1 PMC3797025__F7 Schematic model of adaptive primary resistant responses by tumors to anti–IGF-1R monoclonal antibodies (mAbs) EGFR IGF1R MTOR SRC PMC3387494__F3 The regulatory network of EZH2 CCNE1 CDK2 EZH2 SET PMC3026729__F7 Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice TBX2 HCN4 CACNA1G BMP2 TBX5 GATA4 SCN5A PMC11821632__F1 Canonical and non-canonical TGFB signalling pathways TF TRAF4 SMAD2 SMAD4 MAP3K7 MTOR TRAF6 TGFBR1 PMC8628126__F2 SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases CDC42 HEL113 ROCK2 MAP4 IL6 ARHA RHO HMGN1 CSNK2B STAT1 HMGA1 PAK1 ROCK1 HEL-S-102 MAP6 IL2 ATF1 CTNNA1 MAP2K3 HDAC2 CREB1 PMC9353242__F2 Hedgehog signaling regulates the development and treatment of glioblastoma NEU4 DLG5 QK3 SMO GSC PMC7563227__F2 Roles of PGs in hormone-dependent cancer metastasis STAT3 LRP6 CS SDC1 IL8RB SRC CCL20 PMC4888354__F3 The mechanisms of action of ANG Secreted ANG undergoes receptor-mediated endocytosis from the cell surface to the inside of the cell where it accumulates in the nucleoli under growth conditions or in the cytoplasm under stress conditions PLN PLSCR1 FST MDM2 PMC5557313__F1 Illustration of the complement activation pathway with annotations for quantified glomerular proteins in progressive versus non-progressive IgAN patients CRP C6 CD59 C7 CFHR5 HEL-S-62p C1S CFHR1 VTN CR1 CFHR3 C2 CFHR2 C9 C4B_2 PMC8394119__F1 NAD+ Precursors and Antioxidants for the Treatment of Amyotrophic Lateral Sclerosis IFNG SIRT3 SIRT1 HEL-S-44 PMC6142327__F3 Role of AMPK signalling pathway during compensatory growth in pigs KRT18 RUNX2 CD6 PMC6109777__F4 Cellular protection mechanism conferred by Nrf2-ARE pathway after intracerebral hemorrhage (ICH) BACH1 KEAP1 NQO1 MAF PMC12191222__F3 Top2b-regulated gene, Ubb, is a key player in protein degradation and transcriptional regulation in the retina UBC UBB PMC2703816__F3 Identification of neuronal target genes for CCAAT/Enhancer Binding Proteins CDC42 CEBPA MSH2 FNBP1 BRCA1 EGFR OCEL1 GHRHR CD47 UBB PMC12191222__F2 Top2b-regulated gene, Bbs7, is an essential protein for BBSome-mediated ciliary trafficking RAB3IP LZTFL1 PMC12191222__F5 Top2b-regulated gene, Cetn2, maintains photoreceptor ciliary structure and function CETN3 CETN2 HEL-S-296 PLK1 PMC5777730__F8 Phosphoproteome profiling reveals critical role of JAK-STAT signaling in maintaining chemoresistance in breast cancer SLC26A3 RAF1 PIK3R5 IRF9 GNAT2 PTPN11 MAP3K11 MTOR ARHA PTPN6 NCF1 HRAS STAT1 GFAP GYS1 SPIB CREBBP RPL10 FHL1 GRB2 JAK1 HNRNPK STAM2 PMC12191222__F4 Top2b-regulated gene, Rbp4, is crucial for retinoid transport and visual cycle RPE RBP4 PMC11855151__F10 Chemokine signaling pathway (KEGG: hsa04062) illustrates gene regulation differences between AF and EU prostate cancer patients, highlighting the influence of lncRNAs identified through structural equivalence analysis CDC42 BAD F11 FLG SNAP25 ARHA SHE DOCK2 PMC4818686__F4 Rho Family GTPase signaling pathway alterations in adenoid cystic carcinoma GFAP CYFIP1 RHO PMC5377334__F3 Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133 TF SP1 GEM RXRA TFAP2A MYC PMC2874116__F2 Intrinsic pathway is deregulated in cancer BAX BAD EGFR PMC3652812__F4 Thymidylate Synthase Expression Determines Pemetrexed Targets and Resistance Development in Tumour Cells BAX DHFR MTOR PMC4686057__F4 Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regulators PCDH10 RAB39B MERP1 ABI3BP SLC38A1 MFAP3L NTNG1 LIMCH1 MAF NREP ADAM12 CPNE8 CIT ADAM19 ITGA7 FGD6 LEPR OSBPL8 SEL1L3 DSG2 LRRC8C MAB21L1 PLXNC1 NUAK1 NT5E CDCA7 SDK2 SLC1A2 IKZF2 PRUNE2 MMD PMC8452875__F7 Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease SIRT1 PMC9512240__F4 Radiation-induced Cell Death and Its Mechanisms SLC3A2 NLRP3 GPX4 SLC7A11 PMC3165008__F1 An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis HMX1 SIT1 HEL-S-15 PMC4686057__F1 Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regulators THBS1 COL1A2 ITGA7 COL4A3 LAMC2 THBS2 THBS3 COL6A6 COL3A1 LAMB1 CD47 CD44 COL4A4 COL6A1 COL1A1 ITGA1 COL4A6 ITGA2 LAMB3 COL4A2 COL4A1 COL4A5 COL5A2 LAMA3 PMC9512240__F1 Radiation-induced Cell Death and Its Mechanisms CDC42 CYCS RAC1 PMC8541427__F4 Genetics of Diabetes: What We Can Learn from Drosophila RHEB TSC2 TSC1 PTEN PMC8541427__F2 Genetics of Diabetes: What We Can Learn from Drosophila PTEN TBC1D4 PMC3277713__F1 A schematic diagram of different components making up the interleukin-23 (IL-23) and IL-12 receptors and the common signal transduction and activator of transcription 4 (STAT4) activation pathway STAT4 IL23R TYK2 IL12RB1 PMC8452875__F1 Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease VIP DBP CRY1 NFIL3 AVP PMC3684430__F1 Apoptotic pathways regulated by the UPR BAX BCL2 ATF4 ERO1A EIF2A TRAF2 PMC5538425__F1 Calcineurin–NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy SYK TLR1 TLR4 TLR9 CSK CD14 PMC11506434__F6 NPS-1034-targeted pathways in RCC AXL TNFRSF1A GADD45A PMC8763273__F4 Upregulation of T Cell Receptor Signaling Pathway Components in Gestational Diabetes Mellitus Patients: Joint Analysis of mRNA and circRNA Expression Profiles ZAP70 NFKBIA IL6 AGA TNF LCK PMC8667725__F4 Corona Virus Disease 2019 (COVID-19) as a System-Level Infectious Disease With Distinct Sex Disparities TF LPA VWF TLR4 PLG ADAMTS13 ACE2 PMC8463986__F1 Brain insulin resistance: an early risk factor for Alzheimer's disease development in Down syndrome GSK3B APP MTOR SIRT1 IRS1 PMC7595734__F3 Lipid scavenging by extracellular arthropod-borne pathogens LPL FAS PC PMC8216348__F9 Computational-Based Drug Repurposing Method Targeting SARS-CoV-2 and its Neurological Manifestations Genes and Signaling Pathways SELE ADRB2 GLA IL6 PTGS2 VEGFA ABCC2 PMC6855178__F1 Action of Targeted Therapies in Metastatic Renal Cell Carcinoma HGF AXL MTOR RET VHL PMC11654217__F4 Mechanistic overview of targeting PD-1/PD-L1 by bioactive natural compounds STAT3 SYK STAT1 EGFR MUC1 MTOR TNF PMC11654217__F1 Proposed signaling pathway representing PD-1, PD-L1, and their interactions STAT1 EGF WNT3A EGFR MUC1 MTOR TNF CTNNB1 PMC8581865__F6 Dura cells in the etiopathogenesis of Crouzon syndrome: the effects of FGFR2 mutations in the dura cells on the proliferation of osteoblasts through the hippo/YAP mediated transcriptional regulation pathway LATS1 LATS2 PMC6360698__F2 Molecular signaling of inflammatory pathways involved in structural remodeling TBK1 SMAD1 TRADD SMAD2 SMAD6 CD14 SMAD4 IRF3 MTOR TRAF6 IRAK4 MYD88 TLR4 FADD PMC3590793__F1 ATR barrier to replication-born DNA damage TOPBP1 ATR ATRIP RAD17 PMC12191222__F7 Top2b-regulated gene, Crx, is a master regulator of photoreceptor development and maintenance NRL CRX NR2E3 OTX2 PMC12191222__F6 Top2b-regulated gene, Pik3r1, represents a pivotal signaling cascade in photoreceptor cells PI3 PIK3R1 MTMR4 PTEN PMC7456566__F3 Rhabdomyosarcoma CDKN2A MYOD1 FOXO1 PDGFA FGFR4 ERBB2 IGF1R MDM2 MTOR PLK1 CCND1 CDK4 PMC11654217__F5 Impact of natural compounds targeting PD-1/PD-L1 on various signaling pathways GPX4 PTEN SRC KRAS PMC11889221__F4 Metabolic differences between M1 and M2 macrophages PIG59 PMC11889221__F6 Tissue Macrophages in Diseases TREM2 LRRK2 CCL3 ATM APP CCL4 CCL5 CXCL10 CCL2 TWEAK SPP1 PMC6554685__F9 Cell Cycle and TGF-beta-Signaling Pathway Regulated by the E2F Alteration in Breast CancerThe (A) cell cycle and (B) TGF-beta-signaling pathway regulated by the E2F alteration in breast cancer (cBioPortal) are shown DBF4 THBS1 CDC20 PCNA STAG1 SMAD2 SMAD4 NODAL ARHA SKP2 TGFBR1 BAMBI IFNG RAD21 FST CDC45 CDK2 SKP1 MDM2 PMC10255599__F3 Anti-oxidant and anti-thrombotic activity of Vitamin D and Resveratrol in COVID-19 NR1i1 SERPINC1 HMGB1 NLRP3 PMC10255599__F2 Vitamin D and resveratrol immune response against SARS-CoV-2 infection NR1i1 STAT3 CYP27B1 NLRP3 EBP TANK SIRT1 PMC7719781__F5 Mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) regulates ER stress and insulin signaling VAPB MFN2 PMC4036287__F9 Working model for Fas signaling in cancer-related inflammation and breast cancer progression TES FAS CS FADD PMC6762062__F1 Inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis LTB LOX PMC2908618__F7 Elucidating the CXCL12/CXCR4 Signaling Network in Chronic Lymphocytic Leukemia through Phosphoproteomics Analysis CXCL12 MAPKAPK2 PDK2 MTOR CXCR4 PMC3741506__F1 ASC-mediated switch between pyroptosis and apoptosis: intracellular pathogens and their products lead to activation of the ASC-dependent inflammasome BAX CASP9 CASP8 NLRP3 CASP3 AIM2 IL1B PMC4833425__F6 Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGFB Signaling Pathway GHSR TGFB1 IL13 TRAF6 TNF IL13RA2 PMC6320700__F1 Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era CERS3 CERS5 tmp_locus_29 CERS1 CERS2 CERS6 PMC2891586__F3 Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks DVL1 DTX1 DTX2 ITCH DTX3 DTX4 GSK3B SMAD4 NUMB PSEN1 PSENEN JAG2 LFNG MFNG DLL3 HES1 HES5 DLL4 DTX3L DVL2 RBPJL MAML1 NFKB1 PSEN2 DVL3 EP300 PMC5445378__F1 EGF-R and TGFB signaling pathways interfered by E5 EGFR SMAD2 SMAD4 PMC5445378__F3 Interferon synthesis and signaling pathways STAT1 IFNGR2 IFNGR1 STAT2 IFNAR1 IRF3 ATF2 TYK2 PMC5445378__F2 E5 immune evasion mechanisms HEL-S-92n BAX COX2 EGFR PMC5908975__F7 FAK/paxillin/AKT signaling pathway SOX2 MMP2 MMP9 CCND1 PMC4565673__F1 How to Turn On an Ancient Metabolic Enzyme? Add Insulin and Deacetylate HDAC3 HEL-S-68p MTOR PMC11545938__F1 Sphingosine-1-Phosphate Signaling Pathway in Pancreatic Diseases S1PR1 S1PR3 SPHK2 S1PR2 S1PR4 PMC9240646__F7 Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases FADS3 ALOX12B DEGS1 SDR9C7 SPTLC1 DEGS2 ALOXE3 SSB PMC7153006__F12 Schematic diagram depicting the cytoprotective effects of Kaji-ichigoside F1 and Rosamultin on hypoxia-induced apoptosis of EA.hy926 endothelial cells BAX BAD BCL2 PMC9338646__F1 Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment SIRT7 NAPRT HEL-S-90n SIRT4 SIRT5 CD7 NAMPT MMP9 SHE SIRT3 NADK SIRT1 SIRT6 PMC4123363__F2 The p38A/ERK cross-talk in colorectal cancer BAX SIRT1 PMC7451565__F5 Genome-wide association study for mammary structure in Canadian Angus cows PPARG ART1 PNKD GPBAR1 ARPC2 PENK PCSK5 PTPRE CNTN1 DLX5 GPR139 PMC7451565__F4 Genome-wide association study for mammary structure in Canadian Angus cows CRP HEL-S-92n RIOK3 PADI4 SMAD2 EPHB1 PADI3 PADI1 PMC11117599__F5 SO2 exerts its antifibrotic effects by modulating key intracellular signaling cascades TIMP1 CTNNB1 PMC11117599__F4 Anti-fibrosis mechanisms of H2 in fibrotic diseases NLRP3 SMAD2 SMAD4 MTOR PMC11117599__F3 Anti-fibrosis mechanisms of H2S SMAD2 SMAD4 PMC11117599__F2 Anti-fibrosis mechanisms of CO NLRP3 SMAD2 SMAD4 NOX4 PMC11117599__F1 Anti-fibrosis and fibrogenesis mechanisms of NO/NOS system SMAD2 SMAD4 PMC6631643__F9 Schematic representation of macrophage-derived exosomal miR-501-3p in PDAC and the involvement of TGFBR3-mediated TGFB signaling pathway TGFBR3 MSI2 PMC7408826__F2 Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment EGFR dik PKP1 NOTCH2 MYC LATS1 CDKN2A LATS2 FAT1 KNSTRN MDM2 GRB2 NOTCH1 CDK4 PMC3650130__F216 Recently, Anderson and co-workers described cycloisomerization of O-allyl oximes into pyrroles catalyzed by the Ir(I)/Ag(I)-combined system ALK RET PMC8223819__F1 Dynamics of host immune responses to SARS-CoV-2 NOS2 HGF TLR3 CCL3 C1S TLR8 IL2RA TLR7 PMC11025274__F2 Mechanisms by which the gut microbiota promotes CRC metastasis by targeting seeds CDH2 CEACAM1 TLR4 EGFR AXIN1 NOD2 TPH2 NOD1 CCL2 CTNNB1 PMC9020229__F3 Endocrine Regulation on Bone by Thyroid IGF1 BMP2 IGF1R CTNNB1 PMC8036642__F3 MicroRNAs, Long Non-Coding RNAs, and Circular RNAs: Potential Biomarkers and Therapeutic Targets in Pheochromocytoma/Paraganglioma RHEB TSC2 SOX6 TSC1 TGFBR3 PTEN PMC9020229__F1 Endocrine Regulation on Bone by Thyroid SMAD1 DKFZp781O1323 CPZ IGF1 BMP4 SMAD4 IHH WNT4 IGF1R RUNX2 CTNNB1 PMC2581553__F7 The PpsB product and the proposed interaction between the PDIM and FAS-II pathways FAS INHA HEL-S-5 PMC4748276__F5 ApoCanD: Database of human apoptotic proteins in the context of cancer BAX FAS CASP6 TRADD BCL2 TNF FADD PMC5757244__F5 Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops TSC2 TSC1 ARC PMC5757244__F3 Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops CDH8 HGF APC GSK3B FZD9 LRP5 LRP6 CTNNB1 EN2 BCL9 TSC1 DOCK4 LEF1 DISC1 PMC10532049__F1 Angiogenesis—An Emerging Role in Organ Fibrosis VEGFC ADAMTS14 CCL21 ADAMTS3 CCR7 SOX18 PMC11810461__F1 MiRNAs that regulate 5-FU resistance in GI cancers SOCS1 RAD18 HEL113 KEAP1 PTEN TYMS SOCS3 DUSP2 TGFBR2 RB1 FOXM1 ABCF1 BIRC5 BTG1 E2F3 ZBTB7A GC WEE1 PC DKK2 APAF1 PTN ING4 FZD7 CMPK1 DPYD ID1 EIF4E HOXA13 PMC7275405__F8 Graph of the interaction pathway ABCG8 INSR AQP9 RXRA UGT2B4 LDLR AQP8 CYP3A4 LHCGR PMC3795998__F1 Signaling pathways of the UPR in response to ER-stress ATF4 EIF2A XBP1 PMC3508164__F12 Proposed model of Cripto-1 modulation of the Wnt/Beta-catenin signaling pathway WNT3A DKK1 APC GSK3B LRP5 CTNNB1 PMC4661376__F3 Actin signaling pathways and their association with brain disorders CDC42 CDH2 OPHN1 LIMK1 ARHA SRA1 CTNNB1 PMC7680337__F3 Signaling networks involved in Ras-driven oncogenesis TIAM1 RASSF1 PMC3708280__F1 A simplified scheme of signaling pathways and cellular events involved in embryonic skeletal muscle formation WNT3A BMP4 WNT7A SHH WNT1 PMC9338646__F3 Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment IFNG TBK1 STAT1 CGAS TET1 IRF1 NAMPT IRF3 CCL5 CXCL10 PMC2832191__F3A Regulation of autophagy induction in yeast and mammalian cells RHEB TSC2 TSC1 BCL2 PTEN MTOR EIF2A IRS1 PMC6222750__F6 Proposed signaling pathway triggered by kaempferol in EJ cells BAX BAD ATM CCND1 PMC3708280__F3 Molecular background of major signaling pathways responsible for proper development of muscles and muscle stem cells in normal tissues and tissues affected by laminopathy LMO7 CDC2 EGF BMP4 APC GSK3B MYF5 PPA2 MTOR HES1 CTNNB1 PMC2882188__F3 Complement cascade CD59 SERPING1 MASP2 HEL-S-62p C9 C4A C4B_2 CR1 PMC2821718__F3 Structure and signalling in the IL-17 receptor superfamily IL17RC GSK3B IRF3 TRAF3 TRAF6 MYD88 PMC3994321__F1 Autophagic pathways in mammalian cells ATG10 ATG3 ATG12 UVRAG MTOR ATG5 PMC4924722__F1 The essential role of methylthioadenosine phosphorylase in prostate cancer AMD1 MTAP TK1 TYMS PMC4890907__F3 Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance TG FAS PCK1 PMC5514737__F6 Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins RASGRF1 CRK LIMK2 PAK1 LIMK1 ARHA GRB2 SRC RAC1 DOCK1 PMC2848030__F6 How the presence of virus acts on innate immune system components, i.e EGF NCAM1 IL6 OAS1 OAS2 PMC2964976__F8 CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs FYN CD36 HEL-S-2a PMC9600888__F1 Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling SMAD1 DKFZp781O1323 BMP2 CTSK LRP5 NFATC1 TRAF6 RUNX2 CYLD CTNNB1 ACP5 PMC5714869__F6 Schema depicting the Peli1-mediated pathway following SAH TLR4 PELI1 MYD88 PMC10216440__F2 CGRP cellular pathway RAMP1 SP7 ATF4 RUNX2 PMC7482807__F3 Regulatory function of lncRNAs in BC resistance to anti-HER2 targeted therapy HNRNPA2B1 TINCR MYD88 PMC9358258__F14 Neuroprotective Drug Discovery From Phytochemicals and Metabolites for CNS Viral Infection: A Systems Biology Approach With Clinical and Imaging Validation STAT1 IL10 JUN REN LAT IRF3 TNF PMC7482807__F2 LncRNAs-mediated endocrine therapy resistance EGFR IGF1R DUSP7 PMC6850367__F2 PPARy‐mediated effects in the liver TG FAS CD36 PMC3061277__F1 Simple schema of the IGF pathway and approaches to its inhibition BAD IGF1 MTOR IGF2 PMC4865316__F8 Scheme of the mechanisms by which the lack of ZO-2 triggered cell hypertrophy APC GSK3B PTEN MTOR CTNNB1 PMC2730990__F2 TGFB can leave you breathless MBP APC PMC7449914__F7 Proposed mechanism: HDAC3 regulates the transcription of cGAS by deacetylating p65 at K122, which plays a role in ischemic/reperfusion-induced neuroinflammation and brain injury HDAC3 TBK1 CGAS IRF3 S100B PMC11749404__F1 Synthesis of Phospholipids in association of ER to mitochondria PGP PSD PEMT PC CRLS1 PMC5378054__F4 Regulation of cellular senescence by transforming growth factor B (TGFB) signaling SP1 E2F4 BMP4 BMP2 BMP7 PMC6416297__F1 Reaction-based specification of the model according to the notation previously introduced HEL-S-182mP DHFR HEL-S-61p TYMS MTHFS MTR PMC11620636__F7 LncRNAs induced by SARS-CoV-2 can exert cis-regulation on the IL-27 pathway CSF1 TGFA CCL3 NFKB2 IRAK1 IRAK2 IRAK4 GBP4 GBP5 IFNG STAT1 EBI3 OASL TLR8 JUN CSF2 FOSB IRF3 IRF7 GBP1 RSAD2 IL6 OAS3 TNF CXCL10 ZC3H12A IDO1 JAK1 IL12B PMC8624248__F2 Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development MMP7 CXCL12 EGF SMAD2 SHH MTOR TNF CTNNB1 PMC4898271__F6 The ras signaling pathway EGF EGFR EPHA7 PMC8171374__F1 Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments CD40 ICOS CD80 IL21R TPO CR1 PMC2834863__F1 Transforming growth factor beta (TGFB) and inflammation in cancer CDC42 SMURF1 MAP3K1 PLG RHO TRAF6 SKI STRAP PMC5378054__F1 Transforming growth factor B (TGFB) signaling pathway and its context-dependent regulation SMURF1 C9 PMC6209915__F8 Ras pathway was hyperactivated in Sorafenib-resistant SKOV-3 cells CDC42 ZAP70 SYK JUN GDNF LAT CRKL ATF2 ARHA RAC1 RASA3 FYN RALA BCR RASA2 RIN1 RAP1A GRB2 CCND1 LCK CDK4 PMC7482807__F4 LncRNAs-regulated resistance to targeted therapies beyond HER2 HDAC3 SPEN CDK6 PHLPP1 CDK2 EZH2 PTEN CDC37 CCND1 CDK4 PMC8364356__F1 Imbalanced Coagulation in the Airway of Type-2 High Asthma with Comorbid Obesity HEL-S-92n PLG FDPS PMC5770599__F3 Regulation of important signaling pathways by E3 ubiquitin ligases in CRC CDC2 EGFR APC BRAF CDK2 MDM2 MTOR KRAS SKP2 PMC5770599__F2 Regulation of Wnt/Beta-catenin signaling and oncogenic NFKB pathway by ubiquitylating enzymes in CRC JUN RNF43 APC GSK3B LRP5 ZNRF3 LRP6 TRAF6 TNF CTNNB1 PMC3407218__F5 CXCL12/CXCR4 Axis Triggers the Activation of EGF Receptor and ERK Signaling Pathway in CsA-Induced Proliferation of Human Trophoblast Cells CXCL12 EGF EGFR MMP2 SRC CXCR4 PMC5180413__F10 a In tumor cells expressing ERB (MDA-MB-231, MCF-7), Gamma- and D-T3 bind to and activate the ERB receptor, inducing the expression of pro-apoptotic genes such as MIC-1, EGR-1, and cathepsin-D, finally triggering apoptosis EGR1 XBP1 PMC9656396__F3 Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy ACLY RHEB ACSS2 TSC2 FBXW7 TSC1 SGK1 NADK FASN GSK3B SRPK2 PTEN PMC7299160__F11 Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis SLC3A2 BAX CASP8 TRADD GPX4 MLKL LPCAT3 FACL4 SLC7A11 TNF HEL-S-34 RIPK3 MAP3K7IP1 GC CASP3 RIPK1 MDM2 TRAF2 FADD PMC11087971__F4 The ECM-receptor interaction pathway and (B) the IL-17 signaling pathway VWF IL17RC S100A7 CD36 DMP1 NPNT TAB3 MMP9 CHAD TRAF6 CD47 CD44 TRAF4 TG MMP3 LCN2 S100A9 TRAF2 FADD PMC7957536__F1 Leptin signalling STAT3 GRB2 MTOR IRS1 PMC9146657__F5 Integrated Transcriptomics and Nontargeted Metabolomics Analysis Reveal Key Metabolic Pathways in Ganoderma lucidum in Response to Ethylene SDHA OGDH FDPS ACCS PMC4613493__F1 Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism HEL107 ME1 HEL-S-26 PMC5830027__F2 Metabolic pathway of NUCKS1 in physiological and pathological process NUCKS1 IL6 PMC4613493__F2 Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism FASN HEL-S-32 ME1 PMC8128161__F2 ER protein quality control capacity in metazoans is monitored by the three branches of the unfolded protein response ATF4 EIF2A XBP1 PMC8234989__F1 New Insights into the Clinical Implications of Yes-Associated Protein in Lung Cancer: Roles in Drug Resistance, Tumor Immunity, Autophagy, and Organoid Development LATS1 CDC2 CTCF HEL113 AXL RHO MYC CCND1 PMC7938660__F1 Metabolic formation of hydroxynorketamines from ketamine CYP2A6 CYP2B6 CYP3A4 PMC5295849__F9 Proposed model of CXCL12 signaling to mTORC1 in BMM CXCL12 TSC2 PLCG1 TSC1 PI3 CXCR4 RAC1 PMC5449256__F1 Oncogenic growth factor signaling mediating tumor escape from cellular immunity STAT3 STAT1 EGF ALK EGFR PTEN CCL5 CCL2 PMC6219204__F2 Crosstalk of FGF10 during pancreatic cancer FGF7 ADM SOX9 EGFR NFATC1 FGF10 KRAS PMC3175613__F3 Proposed in vivo innate and adaptive immune responses to AAV vectors TLR9 CCL5 CR1 PMC5240660__F1 Phylogenetic and conserved synteny analysis of PTH related proteins PTH2 SFRS3 MTCH1 RAB44 DSTYK STK38 TMCC2 DENND2D PTHLH PIR ETV7 PTH PI16 PMC3980610__F1 LIF/JAK/STAT3-mediated growth inhibitory signaling in medullary thyroid cancer STAT3 LIF RET PMC3106121__F1 Phosphodiesterases and Cardiac cGMP: Evolving Roles and Controversies RGS2 RGS4 TRPC6 GATA4 PMC3964949__F3 Motif-mediated interactions annotated in the ELM resource mapped onto the KEGG () human Phosphatidylinositol-3′-kinase-(PI3K)–Akt signaling pathway (hsa04151) SYK BAD RBL2 PTEN MTOR EIF4E RHEB TSC2 TSC1 BCR TLR4 HEL-S-11 MDM2 PMC4140952__F1 CPAcP interaction with HER-2 and PI3K/Akt pathway in regulating prostate cell homeostasis BAD PMC5809759__F1 Can Controlling Endoplasmic Reticulum Dysfunction Treat Allergic Inflammation in Severe Asthma With Fungal Sensitization? ATF4 XBP1 PMC4016833__F1 Signaling events in murine heart development and cardiac ESC differentiation SHF ISL1 NODAL TBX5 PMC3347317__F2 Modulation of type I IFN production by PRRSV TBK1 TLR3 RNASEL IRF3 IRF7 GP5 TRAF3 ISG15 JAK1 TYK2 RAC1 PMC7102917__F2 Major downstream signaling pathways in GISTs STAT3 PDGFRA KIT MTOR PMC5682898__F7 Proposed model for the neuroprotective effects of XJDH in OGD/R injury TLR4 TRAF6 MYD88 PMC5240660__F9 Evolutionary history of the PTH family in vertebrates ENTPD5 PTH2 PTHLH CS PHOSPHO1 FGF23 PMC3314445__F9 An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated AB oligomers GLP1R ABO IRS1 PMC9525705__F1 mtDNA acts as a DAMP to activate neuroinflammation NLRP3 TLR9 IRF3 TNF IL1B PMC9280480__F2 SUMOylation Targets Associated With Wnt/Beta-Catenin Pathway RANBP2 CD44 APC LRP5 SMAD4 LRP6 TCF4 PMC6073455__F4 SCF and its active ingredients protect against inflammation in NDs TRADD TLR4 TRAF6 TNF TRAF2 FADD MYD88 PMC2955993__F3 Complement and Periodontitis TLR1 PMC2955993__F1 Complement and Periodontitis CD59 FH HEL-S-62p C2 C1S CD46 CR1 PMC5543471__F8 Molecular mechanism of the mTOR pathway in Vil‐Cre;Pkd2 f3/f3 mice, with or without rapamycin treatment CDC2 ELL CDK2 PMC9553089__F2 Dysregulation of the mevalonate pathway during SARS-CoV-2 infection: An in silico study GGPS1 CD81 HMGB1 RABGGTB COX10 RHO FNTA RARA IPP SIGMAR1 MVD FDPS PGGT1B PMC4478622__F1 Scheme of the engineered metabolic pathway for the production of 1,2-propanediol and 1-propanol in C VIT GID4 PMC5989173__F1 Molecular mechanism of SOCS- and IRF-regulated cytokine signaling in macrophages during ALI/ARDS SOCS3 JAK1 PMC8380478__F2 Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application CD80 FAS CCL21 MSC PMC9497173__F1 Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment GLUD1 RPE GOT2 RPIA GLS HK2 GPT2 MAL GFPT1 HEL-S-32 ME1 CIT PMC7290664__F6 Functions of caspase-2 in DNA damage and cellular stress CDC2 BAX ATR OMP BCL2 ATM PMC2640319__F1 Insulin and amino acid signaling pathway leading to the stimulation of translation initiation RPS6 TSC2 TSC1 PTEN MTOR IRS1 EIF4E PMC7290664__F9 Extrinsic and intrinsic pathways of apoptosis BAX FAS TRADD BCL2 FADD PMC9497173__F3 Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment ATG101 ATG3 ATG16L1 ATG12 ULK1 ATG14 ATG5 ULK2 PMC8198409__F2 Diacylglycerol Kinase alpha in X Linked Lymphoproliferative Disease Type 1 FYN DGKA PMC10942825__F6 Signaling pathways of DUSP22 in EndMT SMAD2 PMC5869001__F6 Hypothesized KS biosynthetic pathway in the absence of functional B3GnT7 CHST5 CHST6 B4GALT4 PMC4376865__F4 H-Ferritin-Regulated MicroRNAs Modulate Gene Expression in K562 Cells CRCP VEGFB RNF20 ASXL2 PMC1560089__F7 Proposed LITAF signaling pathway LITAF TLR4 MYD88 PMC9329130__F1 Over-expression of a cyanobacterial gene for 1-deoxy-d-xylulose-5-phosphate synthase in the chloroplast of Chlamydomonas reinhardtii perturbs chlorophyll: carotenoid ratios IPP HEL-S-62p CS PMC11395697__F8 Tumor–immune interactions and the dynamic interplay between tumor killing and immunosuppressive mechanisms EGF HGF CCL11 OSM CCL3 APC CCL26 ARG1 MMP9 VEGFA CS CCL5 CCL2 FGF2 CCL24 NGF PRF1 HEL-S-130P CCL7 PMC5541935__F2 Comparison of Biomarker Expression between Proximal and Distal Colorectal Adenomas: The Tennessee-Indiana Adenoma Recurrence Study TF EGF FOXQ1 EGFR APC LRP6 MTOR SRC CCND1 CTNNB1 TGFBR1 PMC11395697__F7 Gut microbiome–host interactions in colorectal cancer development TLR4 MYD88 PMC4928883__F3 Fundamentals of cancer metabolism ACLY MTHFD2 FH GLS HK2 HEL-S-51e ACSS2 MTHFD1 PHGDH HEL-S-162eP SHMT1 PC MTHFD2L HEL-S-26 PMC11395697__F4 The colitis-associated cancer pathway in inflammatory bowel disease STAT3 APC PMC11395697__F3 Serrated neoplasia routes BRAF KRAS MGMT PMC4629535__F5 Canonical pathway and gene network analysis of the 18 identifiers that were expressed in the lungs of PQ-free rats DPH1 MAP3K13 SHISA5 GPR39 TRIM35 RASA2 GPR87 PCNT TPRKB TMEM43 TAOK2 GPR161 FFAR3 EIF4EBP1 ZNHIT6 TP53BP1 ZNF675 P2RY14 MKRN1 SPRED1 MAP3K1 GPR137 SHOC2 PEBP4 GPR160 SESN2 PMC4629535__F4 Proposed p53 signaling pathway in PQ-treated rat lungs GML BAX ATR FAS PERP AIP PTEN TIGAR CTNNB1 HIPK2 BRCA1 ATM MDM2 PMC7701955__F2 Canonical and non‐canonical TGF‐B signaling CDC42 FAS SMAD2 SMAD4 MTOR ARHA TRAF6 NOX4 YAP1 TRAF4 SMURF1 SOX9 FOXP3 BIK PMC3724248__F1 MicroRNA pathway is universal to all mammalian miRNAs RAN DGCR8 AGO2 DROSHA PMC3944819__F7 Schematic of ANDV N and GnGc protein regulation of TBK1 signaling TBK1 MAVS IRF3 TRAF3 PMC4629535__F6 Canonical pathway and gene network analysis of the 26 identifiers that were expressed in the lungs of PQ-treated rats DUSP10 BCOR IRF2BP2 PANK1 SHC1 DHODH AAK1 GPR89B RNF125 HIPK2 PAH LANCL1 AIFM1 MARCO UNK DYRK2 UBC CTSW STK17A SP1 CDKN2AIP BRSK1 CD55 CPOX NLRX1 GPR61 NR2A1 VN1R3 MAP3K1 TXNRD3 PACS2 GPR174 VN1R2 VTCN1 ELK3 SESN1 TP53RK ROBO4 TAAR8 YWHAZ PMC6225148__F2 Current understanding of the mechanism of action of T-oligos BAX ATM PMC2275788__F2 Mapping Genetically Compensatory Pathways from Synthetic Lethal Interactions in Yeast RAD18 VPS29 RAD52 SAP30 RAD50 RAD51 CDC73 VPS51 TAF9 ARL1 ARL3 PMC10819295__F2 Possible signaling pathways activated by ORF8 IL17RA IRF3 IL6 TRAF6 MYD88 PMC11847756__F3 Topological analysis of the PPI network using Cytoscape identified 10 key hub genes, shown in this network visualization ALB STAT3 JUN CASP3 BCL2 HIF1A IL6 TNF PMC8469696__F2 Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in Cancer UFD1L SVIP ASPSCR1 PHAX XAF1 VCP UBXN2B PLAA YOD1 PPP1R11 SELS ACTR6 SNTG2 ALKBH5 UBXN11 UBXN10 PPP1R7 TMEM129 VCPKMT SYF2 ZNF778 UBXN7 VCPIP1 UBXN6 PMC7537271__F3 SARS‐CoV‐2 activates innate immune pathways TBK1 HMGB1 NLRP3 TLR3 TLR4 TLR8 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC3077544__F2 Akt regulates numerous biological functions by phosphorylating distinct protein substrates TSC2 BAD PAK1 GSK3B ACAP1 MDM2 MTOR SKP2 PMC3994404__F2 KIT signaling pathways SOCS1 STAT3 STAT1 GRB7 BTK PLCG1 KIT GRB2 PMC11847756__F2 PPI network was constructed using STRING to visualize the interactions among the 140 shared targets between Chrysin and breast cancer TP73 AURKA STAT3 CYP2A6 ABCC1 PCNA GSK3B CTNNB1 TFF1 AFP SULT1A1 CDKN2C ADAM17 SHBG FGFR1 AHR MMP2 DUSP16 FOXP3 ABCC2 POT1 ABCB1 MMP7 NOS2 JUN CYP1B1 MIF ARHA CXCL10 STS NR1C1 RELA HSD17B1 NFKBIA PRSS1 CTNNA1 PMC4466411__F5 Schematic model of the molecular mechanisms associated with PD-induced autophagy in NCI-H460 and A549 cells ATG3 MTOR PMC8235734__F4 Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression CXCL12 CSF1 CCR2 TLR7 CCL2 CXCR4 CD47 PMC4511109__F3 Live to die another way: modes of programmed cell death and the signals emanating from dying cells RIPK3 CASP8 TRADD MLKL CASP3 RIPK1 TRAF3 CYLD TRAF2 FADD PMC11505501__F1 Mechanisms underlying signaling pathway crosstalk in OA SMAD1 DKFZp781O1323 SMAD2 OSCAR CTSK ITGB3 TNF RUNX2 TRAF6 CALCR CTNNB1 CXCR4 ACP5 PMC7682347__F7 NFKB/leukemia inhibitory factor/STAT3 signaling pathway in antibody-mediated suppression of Sindbis virus replication in neurons STAT3 LIF PMC8430581__F2 Large Granular Lymphocytic Leukemia: From Immunopathogenesis to Treatment of Refractory Disease STAT3 ROCK2 APC HEL-S-171mP SOCS3 MTOR IL15RA IL23R PMC12046027__F8 Interferon-Induced OAS-RNase L/PKR Pathway and the effect of hnRNP A1 depletion TLR3 IFIT1 RNASEL IRF7 RSAD2 OAS1 OAS2 PMC4780366__F4 Molecular hypothesis of tumor progression in uveal melanoma, highlighting the role of PRAME reported herein SF3B1 EIF1AX BAP1 PMC3574814__F1 MYC target genes in the polyamine pathway AMD1 SRM MYC EIF5A2 PMC7311357__F1 Illustration of the main components of the ACE/ANGII/AT1R and ACE2/ANG(1–7)/MASR axes along with the other molecular components reported to be involved in SARS-CoV-2 infection (e.g TMPRSS2 APC CTSL FURIN ACE2 PMC10623085__F7 Proposed signaling pathway by which NE mediates HepG2 cell proliferation RHEB TSC2 TSC1 PMC5452197__F3 Schematic representation of the intestinal inflammatory pathway expression altered by Hydryeast supplementation (DHY8) in dextran sodium sulfate (DSS)-induced colitis IFNG NOD2 STAT4 H1-2 PMC5642390__F6 The diagram of a potential signaling pathway that RACK1 regulates the cell proliferation and cell invasion in cervical cancer cells STAT1 CCND1 PMC4445275__F1 Genes involved in the leukocyte transendothelial migration and Toll-like receptor signaling pathways TEC VASP CTSK CD14 LBP FADD PMC3551337__F3 CRM1 regulates the PI3K signaling pathway in MCL SYK BTK BCR CDK2 PTEN PMC7064362__F5 Inhibitory Effect of Rosae Multiflorae Fructus Extracts on the Receptor Activator of NFKB Ligand-Induced Osteoclastogenesis through Modulation of P38- and Ca2+-Mediated Nuclear Factor of Activated T-Cells Cytoplasmic 1 Expression TEC SYK BTK BLNK NFATC1 TRAF6 FOS PMC8909792__F3 Ehrlichia chaffeensis intracellular life cycle and host innate response TLR9 NOD2 TLR7 MYD88 PMC10520786__F2 Nrf2-mediated therapeutic effects of dietary flavones in different diseases ENG FYN KEAP1 SIRT1 PMC8909792__F2 Rickettsia spp. intracellular life cycle and host innate responses TG NLRP3 TLR4 MYD88 PMC7136166__F1 Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease IGF1 PTH PMC12031180__F7 CTN induces apoptosis and cell cycle arrest via the TGFB signaling pathway, and 4-HDK mitigates these effects CDKN1A PARP14 CASP3 PMC10520786__F3 Nrf2 modulates inflammation and apoptosis BAX KEAP1 COX2 PMC8038462__F2 DNA repair pathway in the prostate epithelium involving hereditary prostate cancer (HPCa) related genes: mismatch repair or MMR (A); homologous recombination or HR (B) MSH6 RAD50 LIG1 MSH2 PMS2 BRCA1 BRCA2 CHEK2 PALB2 PMC10992410__F2 Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast ENG MIIP ERG GALP PMC10755469__F2 Crosstalk between neutrophil extracellular traps and immune regulation: insights into pathobiology and therapeutic implications of transfusion-related acute lung injury CGAS GSDMD NLRP3 MPO PMC7871890__F1 Type I and III interferons response following SARS-CoV-2 sensing during controlled (left and central cell) and uncontrolled (right cell) infection TBK1 IFNLR1 MAVS STAT2 IRF1 IRF3 MYD88 STAT1 IFNAR2 IFNAR1 TLR7 JAK1 TYK2 ACE2 IL1B PMC7871890__F2 IFN signaling through the Jak-STAT pathway IFNK STAT1 STAT2 IRF9 JAK1 TYK2 PMC9146752__F1 Research Progress on Transorgan Regulation of the Cardiovascular and Motor System through Cardiogenic Exosomes ERBB4 IRAK1 TSG101 CDIP1 PMC8902450__F8 Gallic Acid Hindered Lung Cancer Progression by Inducing Cell Cycle Arrest and Apoptosis in A549 Lung Cancer Cells via PI3K/Akt Pathway BAX CCNE1 CCND1 PMC3184062__F9 Scheme for poly(I:C)-induced apoptotic signaling pathway in high TLR3-expressing NB cells (left panel), but not low TLR3-expressing NB cells (right panel) TLR3 IRF3 HP PMC7251113__F1 Proposed mechanism of synergy of co-encapsulated vitamin E succinate modified octahistidine-octaarginine (VES-H8R8) and palmityl-doxorubicin (pDOX) PGP ROS1 HRG PMC2836529__F3 Neurotrophin actions on the endothelial cell NGF MMP2 VEGFA BDNF PMC3157706__F1 Molecular pathways in LSCs of CML ALOX5 PTEN MTOR CTNNB1 PMC11948946__F8 Analysis of gene expression related to hormone signaling pathways BIN2 ERF EBF2 PMC6997396__F5 Autophagy in metabolic syndrome: breaking the wheel by targeting the renin–angiotensin system TG TSC2 TSC1 MTOR PMC8574122__F1 PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19 RHEB MLST8 TSC2 TSC1 SGK1 PTEN DEPTOR PMC11850271__F2 Regulatory role of posttranslational modifications in the activation of RIPK1 RIPK3 TBK1 TRADD TAB3 RIPK1 OPTN CYLD PELI1 FADD PMC11850271__F1 TNF-Alpha-driven formation of necroptosis-specific protein complexes RIPK3 TRADD MLKL TANK RIPK1 TRAF2 FADD PMC3275810__F2 Schematic display of the molecular interactions of apoptosis related molecules in dental apoptosis indicating the central position of the mitochondria pathway, which has been shown to be essential BAX EDAR TNLG7C FADD PMC11118972__F5 Effect of pteF deletion on cell metabolism LPA MAL CIT PMC1215521__F7 Possible gene regulation in macrophage THP-1 stimulated by theophylline VEGFC CD36 TCN2 IL6ST PMC4338781__F4 DMXAA modulates mTOR signaling pathway in A549 cells.Notes: A549 cells were treated with DMXAA 10 μM for 24 hours and the protein samples were subject to quantitative proteomic analysis RPS6 TSC2 EIF4B RICTOR TSC1 INSR ULK1 PC ELF3 IRS1 EIF4E PMC3606085__F4 NER pathway RAD1 PCNA PMC4338781__F3 Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach ELF4 ELF2 HEL-S-28 RHO MTOR PMC4137134__F1 Conceivable transforming growth factor (TGF)B1-initiated cellular events leading to myofibroblast activation and extracellular matrix (ECM) synthesis culminating into renal fibrosis SMAD6 SMAD4 POLDIP2 RHO NOX4 PMC6914774__F1 The emerging treatment landscape of targeted therapy in non-small-cell lung cancer EGF BRAF PTEN MTOR PMC7755476__F9 Protein-protein interaction network of E2F coexpression genes (GeneMANIA) CENPM MYB TMEM208 ELMO3 TGFA ECT2 SMAD2 UBE2S BLM RPA1 ID3 SRSF10 CDCA3 TCEA3 E2F3 NOL3 CEP55 PMC6050903__F1 Regulated cell death signaling pathways RIPK3 GPX4 RIPK1 PARP1 IL1B PMC3086918__F1 Mind the dbGAP: The Application of Data Mining to Identify Biological Mechanisms ENG TGFB1 c-fgr GCLC CFH AXIN1 SCYL3 TNMD PMC8495593__F2 Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers RHEB TSC2 TSC1 PTEN PMC8495593__F1 Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers SHH LRP6 SMO CTNNB1 PMC8495593__F3 Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers XPA PCNA XPC PMC4547588__F1 Interferons and other inflammatory cytokines control HBV infection of hepatocytes via multiple, distinct mechanisms STAT1 STAT2 IRF9 JAK1 TYK2 IL1B PMC8236123__F9 Activated neutrophils polarize protumorigenic interleukin‐17A‐producing T helper subsets through TNF‐A‐B7‐H2‐dependent pathway in human gastric cancer CXCR1 CXCL6 CXCL8 PMC3115056__F1 Regulation of neural process growth, elaboration and structural plasticity by NFKB CNTF SYK NGF TRADD SRC BDNF LCK PMC8578378__F1 IL-17 signaling pathway in mucosal candidiasis IL17RC S100A8 IL17A JAK1 TYK2 PMC12008290__F10 Astragalus mongholicus and Hedyotis diffusa willd inhibit cell proliferation by attenuating the miR-582-3p-p27 signaling pathway in LUAD CDK2 CCND1 CDK4 PMC5984065__F5 TGFB induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation Diagrammatic representation of the TGFB signaling pathway in SM10 growth inhibition and trophoblast differentiation SMAD2 SMAD4 PMC3356111__F9 Schematic representation of TNF’s dual effect on rat pinealocytes RELA NFKBIA AANAT TNF PMC2954716__F4 Developmental Programming: Differential Effects of Prenatal Testosterone Excess on Insulin Target Tissues PDE3B RICTOR GSK3A GSK3B MTOR IRS1 EIF4E PMC8096095__F5 SRI-21979 alters the expression of transcripts involved in cAMP signaling and apoptosis BAD FAS CREB3 VAV2 RHO MAPK3 RP1 GNAS BCL2L1 SOX9 ATM AMH HRK BAX CASP2 CTSL ARHA TNF RAC1 ADCY3 PAK1 CASP3 CALM1 BCL2 MAP2K2 CASP10 TRAF2 LMNA FADD PMC2743116__F1 Ras/mitogen-activated protein kinase (MAPK) signaling pathway and associated developmental syndromes (indicated by dashed lines) SPRED1 SOS1 NF1 BRAF GRB2 PMC9604790__F3 Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine LATS1 CD44 BRD4 LATS2 CDK7 EGFR FAT1 SCRIB ARHA NF2 CD63 RAC1 PMC10748259__F8 Antiviral effectors and cell metabolism interactions IFNLR1 IFI6 STAT2 IFNAR2 IFNAR1 CH25H RNASEL IRF3 ISG15 JAK1 OAS1 TYK2 PMC10748259__F7 Involvement of metabolism in viral genome detection TBK1 CGAS MAVS TLR3 TRAF5 TLR9 TLR8 IRF3 IRF7 TLR7 TRAF3 TRAF2 PMC10748259__F6 Molecular mechanisms leading to the detection of viral genome TBK1 CGAS MAVS TLR9 IRF3 IRF7 TRAF3 TRAF4 NLRP3 TLR3 TRAF5 TLR8 TLR7 TRAF2 PMC8471503__F8 Identifying GPSM Family Members as Potential Biomarkers in Breast Cancer: A Comprehensive Bioinformatics Analysis CORT ATR COMP CDC20 APC ATM SKP2 PMC4142049__F3 LOX-1 signaling mechanistically links atherosclerosis, hypertension, and diabetes C2 MTOR SIRT1 PMC3569116__F1 Glucose metabolic pathway PGAM1 ENO2 HEL-S-68p HEL-S-49 HEL-S-162eP DLD PMC7698460__F3 Recent strategies aimed at targeting TAMs in combination with ICIs for melanoma treatment PIGF ARG1 VEGFA CD163 PMC12184675__F3 CGAS-STING signaling pathway in immune responses to SARS-CoV-2 and DNA CGAS IRF3 IRF7 TNF PMC12184675__F2 Molecular mechanisms of SARS-CoV-2-induced pulmonary injury via apoptotic pathways BAX TRADD TRAF2 FADD PMC2279300__F6 Chlamydial Entry Involves TARP Binding of Guanine Nucleotide Exchange Factors SOS1 VAV2 TARP PMC10380759__F2 Clinical Significance of CD73 in Cancer CD80 PMC5992506__F2 Cholesterol synthesis and cancer cell proliferation EGFR ELL PMC12184675__F4 Depiction of the innate immune signalling pathway, focusing on RIG-I/MDA-5/MAVS and their inhibition by SARS-CoV-2 proteins TBK1 MAVS STAT2 IRF9 IRAK1 IRF3 IRF7 TRAF3 TNF TRAF6 IRAK4 MYD88 STAT1 MAP3K7IP1 TLR3 JAK1 TYK2 TOMM70 PMC6052888__F8 Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism ROS1 KEAP1 MTOR MYC PMC6657305__F1 Cellular Compartmentation and the Redox/Nonredox Functions of NAD+ PNP KMO HAAO NAMPT PMC8321875__F4 Neuroprotective Potential of Ellagic Acid: A Critical Review KEAP1 PTEN IRS1 PMC7590081__F1 Catabolic pathways regulating TG levels in cells TG FAS PNPLA3 PMC6052888__F9 Antioxidants neutralize mitochondrial ROS (mtROS) UCP2 MCAT SIRT3 PMC5632899__F1 Schematic diagram of an IL-33 signaling pathway IL33 TRAF6 MYD88 PMC6657305__F3 Cellular Compartmentation and the Redox/Nonredox Functions of NAD+ NUDT13 SARM1 HEL-S-162eP NADK PMC6052888__F5 Tryptophan metabolism mediated immune cell response SIRT3 APC AHR MTOR PMC4072077__F1 MicroRNAs (miRNAs) are involved in pathogenesis of multiple myeloma (MM) by targeting some signaling pathways in myeloma cells SOCS1 STAT3 PSMD10 IGF1 IRAK1 IGF1R MDM2 ASF1B PMC7258858__F1 Actions of thyroid hormones (THs) and their corresponding receptors DKK4 MYB ENG PIM1 CTSH FOXO1 F2 SI CDK2 FURIN CCND1 CTNNB1 PMC4069681__F1 Rho protein GTPases and their interactions with NFKB: crossroads of inflammation and matrix biology CDC42 CD40 ARHH TRADD ARHA RAC3 RAC1 IFNG MAP3K1 BCR RHOB ROCK1 TRAF2 IL1B PMC8465440__F2 Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway HEL164 AURKA SYK MCL1 GSK3B PTPRC CTSS MAPK8 MAOA POR MAPK14 ALOX5 FLT4 PIM3 HEL-S-11 KDR PPIG SRC PIM2 CES1 MAPKAPK2 CTSL CTSK MAP3K1 AURKB NQO2 HEL-S-31 CA4 METAP1 KCNN3 EGFR BACE1 BRAF IGF1R PTPN13 MAP3K14 MPO BTK CA12 INSR NR3A2 TYMP MAP2K3 SELE PTPN1 PDE3B NUAK1 RPS6KB1 IKBKB XDH LYN RPS6KA5 CA9 TYK2 PMC4263464__F1 Top overlapped pathways for non-users (top) and users (bottom) of oral contraceptives.Notes: Hexagon shaped are genes SOCS1 PPP1R12B SYK RAF1 SOCS3 MYC PELP1 BCL2L1 CDK6 MAP2K6 GRIP1 PRKCA CSNK2A1 CDK3 MKRN2 MAPK1 CRKL PTPRT IRS1 ARPC1B ERBB3 ACTR2 CDK5 ARHGEF1 CDK2 BCL2 GRB2 SMURF2 BAIAP2 YIPF2 ARPC4 EGFR SFN PRKCH MYLK CDK8 MAP2K4 NR3A2 ROCK1 CEBPB HEL-S-15 CDK4 JUN IL6 ARHA PTPN6 ID1 TRIM25 NFKB1 HEL-S-69p IKBKB ERBB2 CREBBP IL6ST MAGEA4 PMC7865483__F7 Key players of the CoA biosynthetic pathway in bacteria, yeast and mammals PPCS FGF2 PPCDC COASY PMC3630363__F8 Temporal restriction of the Cdk1/Cdc5/Mus81 pathway outside S phase is important for genome integrity RAD18 CDC2 PMC11721695__S1 hCeO2@CA-074Me Nanoparticles Alleviate Inflammation and Improve Osteogenic Microenvironment by Regulating the CTSB-NLRP3 Signaling Pathway NLRP3 RUNX2 PMC9598519__F10 Glutathione and Glutaredoxin in Redox Regulation and Cell Signaling of the Lens EGFR GRB2 SRC PMC3925422__F3 Breaking bad: Manipulation of the host response by Porphyromonas gingivalis IFNG TLR1 HEL-S-62p TLR4 GSK3B CD14 IRF1 RAC1 PMC5985449__F2 Sialic acid metabolic pathway NANP GNE CMAS NANS PMC7487050__F2 Metastatic process in breast cancer CDH2 HOXA2 CXCL12 HIF1AN SALL4 FOSL1 ZEB2 IL6 VEGFA TWIST1 PMC7487050__F1 Brief summary of miRNA biogenesis and aspects of regulation in breast cancer and metastasis SPRY2 DGCR8 AGO2 DICER1 EGFR METTL3 DROSHA PMC4750533__F1 The Akt pathway and downstream effectors BAX SYK BAD GAL HEL-S-28 PFKFB2 PTEN CD19 MYT1 DEPTOR IRS1 TSC2 BCR SI MDM2 JAK1 GAB2 PMC7487050__F3 TGFB stimulation of EMT, angiogenesis, and stemness in breast cancer progression toward metastasis TH HMGA2 SMAD2 DLL4 SMAD4 PTEN VEGFA ARHA NOTCH2 TGFBR1 HOXD10 ADAM17 SALL4 JAG2 ADAM10 ZEB2 NOTCH3 DLL3 TWIST1 NOTCH1 PMC8224563__F1 Autophagy Induction as a Host-Directed Therapeutic Strategy against Mycobacterium tuberculosis Infection P2RX7 ATG101 SIRT3 TSC2 TSC1 ULK1 UVRAG ATG14 OPTN ULK2 SIRT1 PMC5985295__F2 IFN-dependent and -independent ISG transcription mediated by complexes comprised unphosphorylated STATs IFNGR2 IFNGR1 RP9 STAR IFNAR2 IFNAR1 TYK2 PMC7744330__F8 Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization FZD8 ANKH ENPP1 SFRP1 WIF1 FGF23 PMC5985295__F5 Cooperation of unphosphorylated and phosphorylated ISGF3 and GAF components and IRF1 in the regulation of basal and IFN-induced transcription IFNGR2 IFNGR1 AK2 IRF9 IFNAR1 IRF1 PMC7047626__F2 Mitophagy and DNA Damage Signaling in Human Aging LAMP2 USP30 VPS13D ARIH1 PINK1 SMURF1 USP15 PGAM5 AMBRA1 BNIP3 FUNDC1 PMC8853826__F1 Insulin synthesis and secretion in the islet Beta-cell and its control by mirNas NEUROD1 RYR1 PAX6 PMC7047626__F4 Mitophagy and DNA Damage Signaling in Human Aging TBK1 TSC2 CGAS PINK1 WRN ATM MTOR SIRT1 PARP1 PMC4808853__F2 Long chain polyunsaturated fatty acid biosynthetic pathway ELOVL2 FADS2 ELOVL5 FADS1 PMC10520679__F1 Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets RAB27A RAB27B RAB31 PLD2 EGFR ARF6 RAB13 RAB35 SRC PMC8853826__F2 Insulin signal transduction and metabolic responses in peripheral tissues and their control by mirNas SOCS1 FOXO1 TCF2 SOCS2 PMC7744330__F3 Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization WNT10B ADAMTS14 MMP14 WNT16 NFATC2 DMP1 BMP3 THBS2 THBS3 RUNX2 COL3A1 ENPP1 MYLK POSTN MMP2 FGF23 PTN MYH10 LRP5 CILP2 CLEC4E SPP1 FNDC1 COL25A1 BMP8A XB PTCH1 COL16A1 COL12A1 PTH FLRT2 PMC10520679__F3 An illustration demonstrates the involvement of ncRNAs and oncogenic signaling pathways in CRC metastasis FUT4 ANXA2 PTEN ARHA MTOR YAP1 PMC11575262__F9 Seed and foliar application of nano-selenium improves sesame triacylglycerols and oil yield via photosynthetic pigment and enzymatic and chemical antioxidant enhancement revealed by spectrophotometric, UHPLC-analysis and chemometric modeling ABCA9 HEL-S-5 PC GPT PMC8230057__F1 How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System RAN NUP214 EGR1 IRF3 NUP62 C2 NUP153 IPO5 NXT1 RAE1 CPSF6 CP NUP98 PMC9204157__F6 Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis TBK1 TSC2 GAL TSC1 MAP3K7 IGF1R RHO MTOR PMC5748001__F3 Flexible Roles for Proteoglycan Sulfation and Receptor Signaling EGFR GSK3B LINGO1 RHO MTOR SRC PMC10418475__F1 Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects MC1R DCT PMC2831232__F2 NKT cells in immune-mediated pregnancy loss CD40 TLR4 APC TLR9 CD1D PMC3595309__F5 Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NFKB signaling pathway CSA2 VEGFC CDH17 PMC3118659__F13 NAD+ biosynthesis and salvage pathways NAPRT HEL-S-90n NAMPT PMC4688896__F1 Dysregulation and restoration of translational homeostasis in fragile X syndrome RHEB TSC2 EIF4B TSC1 PDK2 MTOR EIF4E PMC2963142__F1 TLR signaling pathway and downstream effector molecules TIRAP TLR9 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 TLR7 PMC6523349__F3 YAP regulation in early stages of prostate cancer LATS1 FRMD6 ERG NF2 PMC8506026__F7 Crosstalk Between Abnormal TSHR Signaling Activation and PTEN/PI3K in the Dedifferentiation of Thyroid Cancer Cells TSHR PTEN ARHA MTOR PMC3417478__F1 Cyclic AMP elevation leads to induction of the SOCS-3 gene in VECs STAT3 SP3 SOCS3 PMC11635874__F2 BMP signaling pathway in bone regeneration SMAD1 MAP3K7IP1 SMURF1 DKFZp781O1323 GREM1 SMAD6 SMAD4 DLX5 RUNX2 PMC11635874__F1 TGFB signaling in bone MAP3K7IP1 SMAD2 SMAD4 SMURF2 PMC2827416__F5 Impact of high dietary protein on lipid metabolism in porcine adipose tissue at body weight 60 kg LPL TG FAS PMC3707951__F3 Proposed intracellular effects of S100A1, S100A4, and S100A8/S100A9 RYR2 S100A1 S100A4 GC S100A8 RYR1 CCN3 S100A9 CTNNB1 PMC10472646__F3 Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application USP14 CXCL12 IDO1 SIRT1 PMC4267164__F2 NOD1 and NOD2 signaling CSA2 TAB3 RELB NOD2 DAP NOD1 PMC4267164__F1 TLRs signaling TBK1 TLR1 MAP3K7IP1 TIRAP TLR4 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC10472646__F1 Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application CTLA4 FOXP3 ABCB1 CCDC6 PMC3707951__F4 S100A8 induction in macrophages STAT3 TLR3 EBP TLR4 S100A8 IRF3 TRAF3 TRAF6 MYD88 PMC4506691__F2 Pathways of steroid hormone synthesis in 21-hydroxylase deficiency, including backdoor pathway and 11-oxygenated androgens HSD3B2 HSD17B3 HSD17B6 CYP17A1 AKR1C2 PMC6523349__F5 YAP/TAZ regulate prostate cancer stem cells (PCSCs) LATS1 LATS2 SOX2 PDE5A PMC6523349__F4 Hippo pathway regulation of advanced prostate cancer ETV5 LATS2 ETV4 SMAD4 EZH2 PTEN ARHA PMC11541314__F6 Codeine and morphine Metabolism pathway as the most significant curated signaling pathway with a p-value of 3 UGT1A1 UGT1A3 UGT1A9 UGT2B4 ABCC3 SLCO1B1 CYP2C8 CYP3A4 UGT2B7 ABCC2 ABCB1 PMC2827416__F6 Impact of high dietary protein on lipid metabolism in porcine adipose tissue at body weight 100 kg LPL TG FAS PMC6301029__F4 Egg activation in Drosophila CDC2 APC GSK3B PMC3792024__F4 Meta-Analysis Identifies NFKB as a Therapeutic Target in Renal Cancer SOCS1 TCIRG1 PCDH17 TAPBP CMPK2 MYC CCL2 GBP4 HMOX1 STAT1 BTC PSMB10 NMI TLE4 NAMPT IRF1 IRF7 CXCL10 VCAN RNF213 LTB ATF3 CXCL11 ENG IRF2 BCL2 HLA-B VCAM1 HLA-C BDNF CHKA IL15 TNC VEGFC HEL113 FAS BCL2A1 MEF2C PRKCE HLA-F CASP4 IL18 NOD2 IL11 TAP2 ISG15 OAS1 CSTA CD48 CXCL13 PARP14 BLNK CXCL2 SP110 XAF1 LIPG SFRP1 CD44 PTTG1 TLR3 IKBKB BMP2 RPRM TPP2 IL7 TNFSF10 TNFRSF11B PMC4726088__F9 Olanzapine Prevents the PCP-induced Reduction in the Neurite Outgrowth of Prefrontal Cortical Neurons via NRG1 NRG1 ERBB4 PSD BDNF PMC7982428__F1 Hedgehog (HH) signaling pathway and its related regulators, target genes and current therapeutic landscape EGF ITCH BOC BRAF GPC3 KRAS CTNNB1 BMI1 ADRBK1 CD44 FOXM1 GPC5 KIF7 SUFU BCL2 SMO RAB23 ABCG2 GAS1 LEF1 CCND1 GLI3 WIF1 PMC4562315__F1 Emerging roles of YAP and TAZ in cancer LATS1 MOB1A MOBKL1A BIRC5 LATS2 AMOTL2 NF2 AREG PMC9442031__F2 Influence of the gut microbiota on endometriosis: Potential role of chenodeoxycholic acid and its derivatives CYP8B1 BAAT CYP7A1 GCA CYP7B1 CYP27A1 PMC3335841__F3 Reduced Expression of Inflammatory Genes in Deceased Donor Kidneys Undergoing Pulsatile Pump Preservation POLD3 ICOSLG SMAD9 CD244 ITM2C RRAGD ARRB2 ATP6V1A SORL1 HAMP BACE2 CPNE1 MYLIP TIAL1 OGG1 HGS GGA2 DIPLA1 BMP2 IL2 APP POLD2 M6PR PMC3335841__F2 Reduced Expression of Inflammatory Genes in Deceased Donor Kidneys Undergoing Pulsatile Pump Preservation ARHH CDC6 HAVCR1 PMC7428719__F1 Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders NQO1 MTOR PMC8968680__F2 Anticancer Activity of Erianin: Cancer-Specific Target Prediction Based on Network Pharmacology CASP9 BAD APC MDM2 MTOR CCND1 PMC6591730__F3 Causes and Consequences of Enzyme-Induced Cytosine Deamination MSH6 ATR MSH2 UNG POLN PMC5716453__F6 Molecular mechanisms underlying the neuroprotective effect of IGFBP-6 via IGF-1R-dependent signaling BAX IGF1 IGF1R IGF2 IGFBP6 PMC8968680__F3 Anticancer Activity of Erianin: Cancer-Specific Target Prediction Based on Network Pharmacology FLT3 ERBB2 GRB2 CCND1 CDK4 PMC6232560__F3 Oncogenic signaling network activated by bile acids STAT3 EGFR MMP11 PMC4141507__F1 fHLH: becoming a blended family RAB27A PRF1 STX11 LYST AP3B1 PMC2483757__F1 Kinetic model of the EpoR/GATA-1 network implicated in erythrocyte progenitor commitment EPOR EPO PMC5669448__F3 Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles MVK PMC5669448__F4 Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles PSTPIP1 MVK PMC9450364__F4 Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells NDUFB5 URM1 NDUFA9 ENOPH1 CDC23 NDUFS5 PON2 DUT NDUFA13 NDUFS3 SET CDK5 TK1 UQCRB UGDH COX4I1 NDUFB3 NDUFA2 CYLD PMC6331455__F5 Role of Nrf2 in HCC FGF8A KEAP1 FGFR4 GSK3B PMC3418709__F1 Hepatitis C, Porphyria Cutanea Tarda, and Liver Iron: An Update CYP1A2 HFE FECH UROD HFE2 PMC3551337__F2 Major pathogenic lesions in MCL SYK TSC2 BCR RELB CDK2 ATM PTEN TRAF3 MDM2 CCND1 TRAF2 PMC8618802__F7 Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy DRAM1 BAX ATR MCL1 ATM MTOR APAF1 FADD PMC3874812__F8 Cav-1 phosphorylation-dependent LPS signaling pathway in mediating lung inflammation in endothelial cells TLR4 CD14 IRAK1 SRC TRAF6 IRAK4 MYD88 PMC3578301__F4 Early signaling events that underlie fate decisions of naive CD4+ T cells towards distinct T-helper cell subsets IFNG JAG2 FOXP3 RORA GATA3 PMC3578301__F3 Early signaling events that underlie fate decisions of naive CD4+ T cells towards distinct T-helper cell subsets C2 LCK GATA3 PMC5600322__F2 HSC Niche Biology and HSC Expansion Ex Vivo HEL-S-133P MEIS1 TPO HIF1A PMC4705475__F6 RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism KCTD13 RYR2 TAOK2 PTDSS1 TBX6 NAMPT AREG ZIC1 ZP4 SPN MVP PPP4C NRXN1 PMC2805916__F1 Galectins, integrins and cell migration SP1 ADAM15 ARHA PMC7059861__F1 Main pathways of TRP degradation, including relevant enzymes [modified after (, )] IDO1 KYNU KMO AHR IDO2 PMC4562315__F3 Emerging roles of YAP and TAZ in cancer LATS1 TP73 BAX LATS2 APC AXIN1 ATM GPR49 AXIN2 CTNNB1 PMC11174998__F1 One-carbon metabolism BAD DHFR MTRR HEL-S-61p PMC4562315__F2 Emerging roles of YAP and TAZ in cancer LATS1 LATS2 TRIO DICER1 AMOT APC PTEN SCRIB RHO VGLL4 PMC7133116__F2 Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803 RPE SDHA PGP RPIA FBP2 HPR FBP1 TNLG7C PMC7897244__F1 TGFB signaling pathway TGFBR2 BMPR2 ACVR2B ACVR2A AMHR2 PMC9204157__F2 Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis TBR1 PLG ARHA MTOR PMC7897244__F6 Proposed pathological roles of ligand competition SMAD1 DKFZp781O1323 SMAD2 PAH PMC9204157__F4 Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis CXCL12 MAP3K19 EGFR SMAD2 SMAD4 SRC CXCR4 PMC10671169__F7 NXC736 Attenuates Radiation-Induced Lung Fibrosis via Regulating NLRP3/IL-1B Signaling Pathway S1PR1 NLRP3 SMAD2 SMAD4 S1PR4 PMC11949690__F6 Findings—hypothalamic IGF1 signaling can be dynamically regulated GAL IGF1 IGFBP5 INSR FOXO1 POMC NPY CARTPT IGF1R AgRP SPX IRS1 PMC5779870__F1 The PDGF signaling pathway STAT1 PTEN ARHA JAK1 CEBPB PMC3827721__F4 In silico method for modelling metabolism and gene product expression at genome scale AMPH FRK GPT PMC5255577__F7 Proposed model for the role of GAS6 in maintaining oral mucosal homeostasis FOXP3 DUOX2 MYD88 PMC9283897__F3 Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis USP42 TMEM30A TNFRSF10B NEK2 KIF20A SCYL2 CCNA2 ATP7B KIF23 E2F3 AKAP11 KIN ASCC1 CENPF RAB27A FLNB HEL-S-84 RNF2 ERBB3 NEDD4 BRCA1 HSPA4 SIRT1 CEP78 TES UFL1 BRIP1 PHKA1 ATXN10 ACAP2 NARG1L RAPGEF6 PCNA UBR3 ANKRD50 SPECC1 CCDC18 PDCL3 CENPE TUBGCP4 HMGB3 MERTK FOXM1 ADAM17 CCP110 PRC1 CHEK2 TOP2A KIF11 FEN1 NUF2 RRM1 KNTC2 PTPN11 SCAF11 MAD2L1 TMOD3 SLC35A3 GNS TRAPPC11 PMC6448793__F3 Ciliary signaling systems within tumors LRP5 LRP6 PTK7 ARHA MYC AXIN2 CTNNB1 SUFU PDGFRA PTCH1 PLCB1 BCL2 SMO HES1 GLI3 DAAM1 PMC6224120__F2 Breast cancer signaling pathway STAT3 SYK EGF PIK3CA BAD HGF PGR EGFR PIK3R1 SMAD4 MTOR MAPK3 MAPK14 BCL2L1 PI3 NRAS HEL-S-1 KDR RPTOR CASP9 IRS1 GATA3 TP53BP1 EIF4E PARP1 NRG1 IGF1 CASP3 EEF2 BIRC2 DIABLO YWHAZ PMC5143371__F2 Cellular metabolic pathway involved in redox homeostasis MTHFD2 MTHFD1 ME1 HEL-S-26 HEL-S-64p PMC5817809__F1 TKI-induced regulation of glycolytic pathway ENO2 HEL-S-133P HK3 HK2 PFKFB2 HIF1A LDHB TIGAR MYC PGAM1 PGAM2 ALDOB ENO3 FBP2 PFKP HEL-S-49 FBP1 ENO1 PFKL HEL-S-87p PFKM PMC9313337__F4 Comparing Bayesian-Based Reconstruction Strategies in Topology-Based Pathway Enrichment Analysis SOCS1 STAT3 STAT2 SOCS4 JAK3 SOCS5 SOCS2 STAT4 SOCS3 JAK1 CISH TYK2 PMC9313337__F3 Comparing Bayesian-Based Reconstruction Strategies in Topology-Based Pathway Enrichment Analysis JAK3 JAK1 TYK2 PMC8745604__F1 YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises ME1 NF2 PMC8225793__F5 Mouse model of prenatal exposure to Interleukin-6 to study the developmental origin of health and disease MAX IPP IRF9 MAL SMC3 SMAD4 CDK2 APP MDM2 MCM2 PMC9670319__F4 RNA-seq and qRT-PCR analyses reveal the physiological response to acute hypoxia and reoxygenation in Epinephelus coioides POR GNAS GCG PYGL PEG10 F2 SIK2 GIP ChAT GCGR MTOR HEL-S-30 PMC8384902__F5 ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer TF UGCG VRK1 CDC20 HMMR PPP1CC CENPE TCF4 CCNA2 ZIC5 SNCAIP PROX1 CBFA2T2 ASCL1 ROCK1 JAG2 LFNG DLL3 CCNB1 HES1 CDC2 DBF4 PLXNA2 SMG9 ID2 TFDP1 DBH DLL4 SYT4 KNTC2 YBX1 DDC RBPJ SET PTTG1 B3GNT5 RAD1 INSM1 BTG2 NKX2-1 SDK2 FOXA2 KIF18A DLX5 YWHAZ ELF3 PMC5979469__F3 Positive regulation of TERT by WNT signaling pathway specific protein (Beta-catenin) and STAT3; (B) SMAD transcriptionally repressed TERT; (C) BC032469, a lncRNA contained sequences which showed complementarity to miRNA-1207-5p seed regions STAT3 TERT CTNNB1 PMC8569443__F1 Functional Roles of Non-coding RNAs in the Interaction Between Host and Influenza A Virus STAT1 MAVS STAT2 IRF9 IRF3 IRF7 JAK1 TYK2 PMC8745604__F4 YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises CSF2 CSF1 EGFR IL8RB CSF3 PMC8745604__F3 YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises LATS1 OGT LATS2 FZD4 JCAD RHO PMC3917325__F1 Chondroitin sulfate and HS biosynthesis CSGALNACT2 CHST14 CHSY1 CHST11 CHST3 CHST13 CHST7 B3GAT2 CHSY3 CHPF FAM20B B3GAT1 B3GALT6 CSGALNACT1 B3GAT3 XYLT1 EXTL2 CHST12 UST PMC5432387__F1 Type II Transmembrane Serine Protease Mediated Signaling in Cancer TMPRSS2 HGF TMPRSS4 MTOR SRC RAC1 PMC3660694__F1 Oncostatin M signaling pathway- NetSlim (http://www.netpath.org/netslim/NetSlim_114) map generated to graphically represent the different reactions induced by OSM in various cell types STAT3 JUND RAF1 SHC1 OSM SOS1 PXN JAK3 MAPK9 SOCS3 MTOR MAPK3 PRKCH PRKCB STAT1 PRKCE OSMR LDLR PRKCA MMP3 SRC CEBPB CREB1 MAPK1 CASP9 TIMP3 EGR1 JUNB PTK2B VEGFA KRAS FOS IRS1 HRAS RICTOR NFKB1 CDKN1B RELA CASP3 NFKBIA IL6ST GRB2 PMC7238289__F1 Pathophysiology of Alcoholic Hepatitis and Mechanisms of Action of Novel Therapeutic Agents ALB IF2B1 CXCL1 CXCL8 PMC9615310__F1 Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H2S homeostasis SHH pcap SQOR HEL-S-61p MTR PMC5085669__F1 MTOR signaling network in mammalian cells RHEB TSC2 TSC1 IGF1 ULK1 DEPTOR IRS1 EIF4E PMC8977320__F1 Edifying the Focal Factors Influencing Mesenchymal Stem Cells by the Microenvironment of Intervertebral Disc Degeneration in Low Back Pain AQP2 NOS2 ACCN3 BMP7 ASIC4 ASIC2 GPC3 GDF6 GDF5 NGF IGF1 MSC BDNF GLI3 NOTO PMC10316197__F3 Apoptosis in NAFLD patient POLG2 BAX NME4 SRSF6 RNASEL IRF3 RAC1 PMC10316197__F2 Inflammation on NAFLD progression STAT3 TNFAIP3 TLR4 TLR9 TNF IRS1 PMC6067120__F4 Schematic representation of estrogen metabolism and AHR signaling pathways CYP1A2 AHR CYP1A1 PMC3740690__F1 Protein Tyrosine Phosphatases and Type 1 Diabetes: Genetic and Functional Implications of PTPN2 and PTPN22 AK2 FOXP3 PMC5522276__F2 HABP2 p.G534E variant in patients with family history of thyroid and breast cancer MUSK SKIL GNAT2 TLK2 DYSF PTPN21 MAPK3 LGALS2 TRIM24 NDN ARL1 ABCC2 MCAM MSH2 FLNB ARL14 GOLGA4 NCF4 RIF1 NEK1 TCF3 PKP4 HSPA4 CDC27 FKRP ZFHX4 TNS1 CS PCK1 COL24A1 ISM1 MYLK FCHSD1 SEC16A TTK NKX2-5 OPLAH ULK2 MYH2 DNMT3B CITED4 CPZ PLXNB2 MTA3 VWA2 PTPRK HEL-S-30 LIPG IARS2 SYTL2 NAT10 ERN2 DDIT3 AMHR2 DHRS2 PMC8345931__F8 Cytokine-Laden Extracellular Vesicles Predict Patient Prognosis after Cerebrovascular Accident CCL13 CCL24 CD80 CXCL17 PPBP USF2 CCL15 CCL7 AIP TNF KITLG PMC8459566__F1 Hypofibrinolysis in type 2 diabetes and its clinical implications: from mechanisms to pharmacological modulation CRP TF PLN VWF HEL-S-62p PLG IRS1 MPO PMC3504424__F5 Transforming growth factorB (TGFB) pathway SMAD2 SMAD4 PMC3504424__F4 Tyrosine kinase receptors pathway JUN EGFR PTEN ATF2 RHO GRB2 MYC FOS PMC3502106__F5 Feed-forward signaling in which FGF-9 controls Wnt-2a expression and mesenchymal Wnt/Beta-catenin signaling BMP4 FGF10 WNT7B CTNNB1 PMC6214025__F9 Combined nano-therapy strategy of MSN containing DOX and AgNPs in cancerous cell NPS MSH2 ERCC2 XDH HEL70 TOP2A PMC11505109__F2 DNA damage response (DDR) pathway activates the ATM-CHK2-P53 signaling pathway and inhibits CDK2 expression, thereby affecting the G1/S transition CDC2 ATR WEE1 CDK2 ATM PMC3504424__F3 Canonical Wnt-Beta-catenin pathway APC GSK3B CTNNB1 PMC8745058__F4 High-Grade Cervical Intraepithelial Neoplasia (CIN) Associates with Increased Proliferation and Attenuated Immune Signaling JUN MXD1 CXCL1 ARG1 PTGS2 MMP9 CXCL10 MYC FOXM1 NCAM1 CDKN3 CCL20 TOP2A PMC6687873__F7 IRE1Alpha-XBP1 pathway of the UPR in CF TLR4 IL6 TNF PMC7171093__F7 Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression STAT3 TLR4 MYD88 PMC6221911__F1 Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models ACHE RNF146 BCL2 MTOR NOTCH2 BDNF PARP1 PMC9030253__F4 Phytoplankton Toxins and Their Potential Therapeutic Applications: A Journey toward the Quest for Potent Pharmaceuticals BAX FAS ATM FADD PMC5458216__F7 Mechanism of modulation through PI3K-AKT pathway about Nepeta cataria L.’s extract in non-small cell lung cancer CRK PTEN MTOR SRC EIF4E PMC5333385__F2 Proposed biosynthetic pathway of sex pheromone production in female DBM moths (adapted from [, , ]) FAS tmp_locus_29 PMC4057789__F1 Cross-talk between EpCAM signaling and the Wnt pathway EPCAM APC SOX2 GSK3B FHL2 MYC CTNNB1 PMC3288148__F1 Three pathways contribute to cellular BH4 levels, the synthesis pathway, the salvage pathway and the recycling pathway SPR DHFR PMC7555758__F1 Interplay between neurons and glia in various conditions IGF1 IL33 ARHA BDNF IL1B PMC8145797__F1 Host Factors That Control Mosquito-Borne Viral Infections in Humans and Their Vector AGO2 DPT FADD MYD88 PMC6756887__F8 Graphical abstract of the senescence pathway in Idh2-deficient conditions ROS1 CDK2 PMC4636224__F6 Dual Action of miR-125b As a Tumor Suppressor and OncomiR-22 Promotes Prostate Cancer Tumorigenesis ERBB3 ERBB2 PTEN PMC6232796__F3 mTORC2 in cell metabolism ACLY FAS GLS HEL-S-133P FOXO1 SLC7A5 PMC7886702__F5 Molecular and functional profiling of apical versus basolateral small extracellular vesicles derived from primary human proximal tubular epithelial cells under inflammatory conditions TRIM38 LIMS1 HAPLN3 HEL-S-62p SQLE AIM2 CCL5 TNF LILRA4 IFNG TRAF4 IL25 STAT1 SLC52A1 PTTG1IP CRLF1 C5AR2 SARM1 S1PR2 F2 PLEC PMC7886702__F4 Molecular and functional profiling of apical versus basolateral small extracellular vesicles derived from primary human proximal tubular epithelial cells under inflammatory conditions HAPLN3 CSF1 AGO2 MYH10 PRDM1 AGTR1 UBASH3B IRF8 GBP1 TNF GBP5 STAT1 PRF1 MAP2K6 FOXO1 TNFAIP2 BCL6 LBP PMC8918930__F8 Chinese Herbal Extracts Exert Neuroprotective Effect in Alzheimer’s Disease Mouse Through the Dopaminergic Synapse/Apoptosis Signaling Pathway ARHG GNG4 PPIF PRPF4 GSK3B PPP2CA PPP3CC SNRPF MAGOH RPL19 NEMF POLR2G U2AF2 PSMC6 SART1 PHF5A BCL2 ERMN MRPL16 PMC4644296__F3 Androgen receptor activation pathways STAT3 EGFR JAK1 IL6R CTNNB1 PMC5833788__F7 NIT1 and TGFBeta-Smad2/3 signalling pathway in colorectal cancer TF TGFB1 SMAD2 SMAD4 PMC6668582__F1 Urea cycle pathway NAGS ASL OTC PMC6514070__F3 Cellular pathways and major players for the induction of the immediate early genes egr (a) and c-jun (b), and downstream targets, with focus on pathways previously linked to learning and memory in honey bees [, , , ] EGFR F3 PMC5875170__F2 Regulation of adiposity by mTORC1 RHEB MLST8 ULK1 DEPTOR PMC8586701__F5 Krill Oil Alleviated Methamphetamine-Induced Memory Impairment via the MAPK Signaling Pathway and Dopaminergic Synapse Pathway TH EGF JUN TNF MAPK8 KRAS FOS MAPK3 MAPK14 NGF DRD2 IGF1 CASP3 APP BDNF CREB1 PMC8620939__F3 MTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy TFEB FLCN MTOR PMC8620939__F2 MTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy MLST8 TSC2 TSC1 ULK1 DEPTOR SIRT1 PMC5219787__F4 Hedgehog signaling pathway SUFU PTCH1 GSK3B SMO PMC7138402__F5 Schematic model by which RACK1 promotes the progression of OSCC CD80 TLR4 CCR7 CD163 PMC5219787__F3 Wnt signaling pathway APC GSK3B LRP5 LRP6 PMC5219787__F6 Ezrin pathway CD44 RHO PMC5219787__F5 PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways TSC2 TSC1 PTEN PMC3822435__F3 Molecular Pathogenesis of Endometrial and Ovarian Cancer BRCA1 BRCA2 PTEN CTNNB1 PMC7123827__F4 3 signals of T-helper cell activation CD80 APC PMC7796397__F2 Two major RNA export receptor pathways, nuclear RNA export factor 1 (NXF1)/nuclear transport factor 2-like export 1 (NXT1) and chromosome maintenance protein 1 (CRM1), are shown, and both are dysregulated in cancer RANBP2 TREX2 TPR NXF3 NUP153 RANBP1 NXT1 RAE1 NUP62 PMC8509622__F3 Epoxyeicosatrienoic Acids and Fibrosis: Recent Insights for the Novel Therapeutic Strategies ARHA NFATC3 TRPC6 PMC9570193__F8 Alterations of Central Liver Metabolism of Pediatric Patients with Non-Alcoholic Fatty Liver Disease GAL MAL GIP GLA INS LPA RPE MALL GRAP MOS CLU HAL MVD HEL-S-11 CIT ADA PMC6553645__F3 Roles of mTOR complexes in the kidney: implications for renal disease and transplantation APC PC VCAM1 PMC7694322__F1 Melatonin biosynthesis and intracellular signal-transduction pathways activated by stimulation of melatonin specific receptors MT3 GC ASMT PMC7125019__F1 MTOR signaling pathway MLST8 SGK1 ULK1 HIF1A YY1 RHO DEPTOR PMC3174986__F3 Plasmodium falciparum-Infected Erythrocytes and IL-12/IL-18 Induce Diverse Transcriptomes in Human NK Cells: IFNA/B Pathway versus TREM Signaling IFNG STAT1 STAT2 PSMB8 IRF9 IFIT1 IFIT3 PIAS1 IRF1 IFI35 PMC8333067__F6 Pattern recognition receptors in health and diseases TBK1 MAVS TLR3 TLR4 TANK IRF3 TRAF3 MYD88 PMC11763799__F1 EGFR signaling pathway scheme STAT3 EGF EGFR BRAF PTEN MTOR MYC PMC11763799__F3 RAS triggering processes in cancer cells FOXM1 CDK6 IRF2 IL6 MTOR VEGFA MYC CDK4 CXCL3 PMC9496891__F4 Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases C2 PI3 GADD45A CCND1 PMC4981729__F1 Proposed regulation of HSC quiescence by paternally imprinted DMRs MTOR IGF2 PMC5729527__F2 Scheme of reported cross-talk between core Hippo pathway components and wt (left) or mutant (right) p53 LATS1 LATS2 RASSF1 MDM2 SIRT1 PMC5729527__F1 Simplified version of the key factors within the Hippo signaling pathway LATS1 TF LATS2 PMC7376204__F6 Significantly enriched KEGG pathways for a down-regulated gene set after 24 h CM03 treatment GSK3B PTEN MTOR SESN2 DEPTOR PMC3397482__F2 Map of the VEGF signaling pathway (as an example of an important target in cancer therapy) obtained from KEGG is shown BAD COX2 SRC PMC6937575__F5 The CD38/cADPR/NAADP-signaling pathway SARM1 PMC9179506__F1 Insights into the Possible Molecular Mechanisms of Resistance to PARP Inhibitors BRCA1 PTEN PMC4307931__F1 Collagen XIA1 in cancer promotion DDR1 MMP3 MMP9 NCL PMC3397482__F4 Cytoscape is an open-source bioinformatics software platform for visualizing molecular interaction networks and integrating these networks with other state data RAI1 PMC3418756__F6 Immune activation in the GBS UTI transcriptome comprises prominent cytokine-cytokine receptor signaling CXCL9 STAT1 FAS STAT2 IL2RG LYN IL1A IL10RA CXCL10 PMC3422477__F1 Apoptosis affects cell signaling pathways that control lipid synthesis and energy metabolism ACLY TSC2 FASN ATM TIGAR PMC5588661__F1 Action of metformin on cancer TSC2 TSC1 IGF1 FASN MTOR PMC2245955__F5 Gene expression changes observed in Sema3A signaling pathway CRMP1 ARPC5 SEMA4G NETO1 SEMA4B GSK3B SEMA3E ACTA1 NETO2 FYN RHOD MICAL3 SEMA7A PLXNA2 LIMK1 L1CAM SEMA6B TUBG1 ARPC1B SEMA3C CDK5 SEMA3D PLXNA1 PAK1 PLXNA3 MICAL2 SEMA6A FES TUBA8 ACTG2 TUBG2 CDC42 ARPC4 TUBD1 ARPC2 ARPC3 WASL DPYSL3 PLXNA4 RAC3 MYLK ACTA2 SEMA5B DPYSL4 SEMA6D MICAL1 ROCK1 SEMA5A RND1 SEMA4C SEMA4F NRP2 ARHA RAC1 HEL-68 SEMA4D SEMA3A SEMA3B PS1TP5BP1 PMC3855473__F2 Tax-specific noncanonical NFKB pathway CD40 RELB TRAF3 TRAF2 PMC3855473__F1 Canonical NFKB activation by TCR/CD28 and HTLV1 Tax MAP3K7IP1 REL PIN1 PMC8147357__F1 mTOR Signaling in Metabolic Stress Adaptation RHEB TSC2 RICTOR PTEN EIF4E PMC7756126__F5 Usage of lymphoma B-cell receptor (BCR) antigens for targeting lymphoma BCR SAMD14 ELL PMC11583678__F4 Elucidated mechanism of OMVs APC MYD88 PMC8915915__F2 Centrality of Myeloid-Lineage Phagocytes in Particle-Triggered Inflammation and Autoimmunity TRADD TLR4 TRAF6 TRAF2 IL1B MYD88 PMC9179423__F3 Bottom-Up Approach to the Discovery of Clinically Relevant Biomarker Genes: The Case of Colorectal Cancer BAX BAD MSH2 POLK APC CASP3 SMAD4 GRB2 PMC7177420__F1 Harmful effects and mechanisms of alcohol GFAP COX2 CCL2 IL1B PMC3445042__F7 The role of Wnt signaling in hypothalamic progenitor differentiation DCX GFAP SOX2 SOX3 HES1 PMC7051217__F3 Complement factor I deficiency HEL-S-62p CFI PMC7600397__F4 DNA damage response pathway (DDR) ATR RAD50 BRCA1 H2AX WEE1 ATM PMC9699766__F7 lncRNA HHIP-AS1/HHIP modulates osteogenic differentiation of BM-MSCs by regulating Hedgehog signaling pathway HHIP SHH SMO RUNX2 PMC3325426__F1 The miRNA biosynthesis pathway from the nucleus to the cytosol XPO5 DICER1 DROSHA PMC7216814__F7 Network regulation map of downregulated miRNAs, SOX2, and other genes in the platinum drug resistance pathway BAX CASP9 MSH3 PDPK1 TNFSF6 AKT3 CYCS BCL2 ATM APAF1 TOP2A FADD PMC10917885__F1 UST treatments specifically target the IL-12/IL-23 signaling pathway STAT3 STAT4 UST IL23R TYK2 PMC3666582__F7 IDENTIFICATION AND DESCRIPTION OF A NOVEL MURINE MODEL FOR POLYTRAUMA AND SHOCK STAT3 HMOX1 TRAF6 TYK2 LBP PMC5063588__F9 How Thbs4 functions as an intracellular regulator of muscle cellular attachment and membrane stability TG THBS4 PMC3149005__F6 Summary of the UPR pathway in rotavirus infected cells ATF4 RET PMC9609401__F3 Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond HEL-S-302 DHFR HEL-S-61p HEL-S-1a PMC9609401__F1 Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond HEL-S-61p MAT1A PMC8011569__F4 Analysis of gene pathways for MENT, LH alone or in combination (MENT+LH) to regulate steroidogenesis HSD17B4 FDXR HSD17B3 STAR CYP17A1 CYP11A1 HSD3B1 FDX1 PMC9403273__F1 Inflammation in hematopoiesis and bone marrow failure: What can we learn from mouse models? RIPK3 TRADD TLR3 MLKL TLR4 BATF2 TLR9 TNF FADD PMC3311998__F6 Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate HEL-S-133P CS HEL-S-26 PMC9358977__F2 Immune-mediated inflammatory diseases with chronic excess of serum interleukin-18 CDC42 NLRC4 NLRP3 HEL-S-52 PMC6675034__F4 Full candidate pathway that represents molecular drivers of tumorigenesis in the sarcoma of patient 1 AURKA EWSR1 ETS2 EIF4EBP1 PIK3R2 AKT3 SH3RF1 PTEN PTGS2 MTOR IL6 IL6R BIRC5 ARNT2 ALK NTRK1 ATF1 JAK1 CALCA CALCB ATL1 SLC1A1 CCND1 TOP2A PMC2807132__F2 p38 signaling to the chromatin in muscle progenitor cells CDC42 HMGB1 MEF2D PMC7072222__F2 Nucleolar surveillance pathway RPL5 RPL11 MDM2 PMC6935412__F3 Increased IFNB enhanceosome components in lupus B cells STAT1 CGAS TLR3 BCR STAT2 IFNAR2 IFNAR1 TLR9 IRF3 IRF7 TLR7 MYD88 PMC3688817__F8 PPARB Regulates Liver Regeneration by Modulating Akt and E2f Signaling ACLY CDC2 CDK2 CDK4 PMC9285505__F1 Hydrogen sulphide in liver glucose/lipid metabolism and non‐alcoholic fatty liver disease PMC6698416__F3 Challenges in deconstructing multicomponent cell responses triggered as a result of uncontrolled RES-exposure KEAP1 PTEN CTNNB1 PMC1169236__F2 Metabolic reconstructions of the polyamine pathway based upon pam and sam analyses of poor-prognosis human NE tumors SMS SRM PMC2605486__F4 Olig2 and the transcription factor network controlling motor neuron differentiation ISL2 ISL1 IRX3 SOX1 SOX2 SOX3 OLIG2 SOX21 PMC4128044__F2 MTOR pathway as a therapeutic target RHEB TSC2 TSC1 PMC5889750__F10 The Transcriptional Response of Skin to Fluorescent Light Exposure in Viviparous (Xiphophorus) and Oviparous (Danio, Oryzias) Fishes C2 C1S C4A PMC2605486__F3 Progressive changes in progenitor cells during motor neuron development SOX13 SOX2 OLIG2 SOX10 PAX6 ISL2 ISL1 SOX9 SOX1 SOX3 SHH SOX21 SOX8 PMC4128044__F1 MTOR pathway is a central regulator of cellular processes PRR5 SGK1 DEPTOR PMC5482185__F5 Diverse cellular functions of arrestin scaffolds BCL2 MDM2 CTNNB1 PMC4749494__F5 The effects of extracellular CypA and MM284 in experimental BA MMP7 TIMP1 TIMP4 SMAD4 TGFBR1 PMC8664591__F1 Appetite Regulation of TLR4-Induced Inflammatory Signaling TRH CRH POMC MC4R NPY ARC PMC4826392__F3 The dynamics of TET-mediated cytosine oxidation and its impact on DNA methylation patterns on regulatory elements in vivo TET2 TET1 TET3 TDG PMC4826392__F2 Pathways of DNA demethylation mediated by TET enzymes TET2 TET1 GC TET3 UHRF1 TDG PMC7551039__F1 Immune checkpoint-mediated T-cell inactivation ZAP70 TIGIT APC BTLA CTLA4 LAG3 PMC9230919__F1 Folate Related Pathway Gene Analysis Reveals a Novel Metabolic Variant Associated with Alzheimer’s Disease with a Change in Metabolic Profile MTHFD1 DHFR ChAT MTR PMC5398990__F3 Schematic overview of underlying pathophysiology and targeted therapies in neurofibromatosis 1 (NF1)-associated malignant peripheral nerve sheath tumors (MPNSTs) AURKA CDKN2A NF1 MTOR PMC8065873__F2 Anti-metastatic mechanisms of herbal medicine in colorectal cancer: Herbal medicines suppress angiogenesis, migration and invasion via inactivation of diverse HIF-1A pathways CDC2 VEGFC CXCL12 EGFR CCR2 GSK3B VEGFA CCL2 CTNNB1 LOX IGF1 ERBB2 SRC CXCR4 PMC8065873__F1 Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery CDC42 STAT3 BAX VEGFC SP1 PCNA H2AX KYNU MTOR VEGFA CDK2 SRC CXCR4 PMC5612509__F1 Complement-mediated haemolysis in chronic cold agglutinin disease and cold agglutinin syndrome HEL-S-62p C2 PMC8944968__F3 Circular RNA ITCH: An Emerging Multifunctional Regulator ITCH APC GSK3B CTNNB1 PMC8065873__F5 Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery CDH2 CDC2 RPE CXCR3 STAT3 EGFR CCR7 PLG CS VCAM1 IL1B PMC8065873__F4 Anti-metastatic mechanisms of herbal medicine in liver cancer: Herbal medicines interrupt signaling transduction and EMT cascades related with cancer cell migration and metastasis STAT3 WT1 RGS5 DLX2 MTOR CXCR4 CTNNB1 PMC8065873__F3 Anti-metastatic mechanisms of herbal medicine in gastric cancer: When it comes to ROS, it has double-edged aspects in anti-tumor efficacy and mechanisms CDC42 CDH2 GPX4 CCND1 MPO PMC11629574__F8 Schematic diagram showing the yes-associated protein 1 (YAP1) as a critical molecular pattern for diabetic kidney disease (DKD) LATS1 TFAM LATS2 PINK1 CCL19 CXCL1 IL6 CXCL6 YAP1 PMC2648620__F2 Insights into the Roles of Gut Microbes in Obesity STAT3 JUN TIRAP CCL2 IL1B MYD88 PMC4974519__F1 The induction of ER stress and UPR during coronavirus infection ATF4 EIF2A XBP1 PMC8521937__F4 Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy UFD1L NEDD8 RBX1 KEAP1 MAF PMC2733092__F4 Intersection sets of the differentially expressed miRNAs constitute complex interaction networks.A Venn diagram illustrating the production of intersection sets from three miRNA target prediction algorithms PPARG MYOD1 SOX6 SOX9 BMP4 PBX1 RFX1 VEGFA MYC RUNX2 PMC6604516__F7 Graphical signalling pathway of the effect of APPBP2 on NSCLC via PPM1D and SPOP.The blue lines indicate the activation of the targets according to our experiments or published researches PPM1D SPOP APPBP2 CDK4 PMC3394800__F5 Developmental Changes in the Metabolic Network of Snapdragon Flowers IPP SHD CS PMC3394800__F4 Developmental Changes in the Metabolic Network of Snapdragon Flowers RPE HEL-S-162eP PMC4026703__F1 Schematic diagram showing the central role of the BMP6-HJV-SMAD signaling pathway in hepcidin regulation and the proposed interaction with other hepcidin regulators BMP6 EGF SMAD1 TFR2 HGF DKFZp781O1323 TWSG1 GDF15 HFE MTOR TMPRSS6 HFE2 PMC7151129__F1 The retinoic acid signalling pathway during development RDH10 DHRS3 PMC3394800__F7 Developmental Changes in the Metabolic Network of Snapdragon Flowers CS PSPH PMC8920937__F8 TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway BAX BAD CASP3 TMBIM1 PMC3840081__F2 Estrogen-induced ER-mediated pathways of vascular relaxation GC ARHA PMC3108474__F2 Membrane type-MMPs regulate vascular cell signaling in cancer HBEGF MMP2 MMP9 MTOR SRC PMC9228236__F4 Assessing Gene Expression Related to Cisplatin Resistance in Human Oral Squamous Cell Carcinoma Cell Lines CDH2 CD44 MAFK MPZ RHOD CNTN2 DROSHA PMC3632219__F7 Proposed roles of PLCB1 in degradation of endocannabinoids at implantation sites COX2 PLCB1 FAAH PMC9428582__F2 Targeting O-GlcNAcylation to overcome resistance to anti-cancer therapies HMOX1 OGT FTH1 TFRC PGM3 CLU EGFR FBL SLC29A1 PMC9084533__F8 Role of OPTN on myogenesis during muscle regeneration MYOG APC GSK3B OPTN CTNNB1 PMC2963118__F2 HRS cell and its cellular microenvironment IFNG STAT1 CCL5 PMC3736507__F2 Schematic diagram showing that cartilage matrix homeostasis is adjusted dynamically by TGFB signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC5641113__F9 Genome-wide functional analysis on the molecular mechanism of specifically biosynthesized fluorescence Eu complex SYK EIF4B BAD CYRIA IL2RG PKN2 RBL2 KIT PTEN CD19 ATF2 MTOR ANGPT2 RAC1 EIF4E RHEB BCR PI3 RXRA MEI1 MDM2 HEL2 PMC8059100__F8 Schematic presentation of possible mechanism of VERU-111 in CxCa CDC2 STAT3 BAD TIMP1 CDK4 PMC6216000__F1 Radiation and tyrosine kinase inhibitor resistance EGFR GRB2 MTOR PMC4714660__F1 Human dendritic cell (DC) response to Toll‐like receptor (TLR)2/3 adjuvants HMGB1 TBK1 TLR9 TLR5 IRF3 MYD88 TLR1 TLR3 TLR4 TLR8 BATF3 TLR7 CD8A TLR10 PMC4383269__F9 Human Papillomavirus 16E6 and NFX1-123 Potentiate Notch Signaling and Differentiation without Activating Cellular Arrest LORICRIN HES1 NOTCH1 HES5 PMC11532153__F3 Functions of p120-catenin in physiology and diseases TIRAP TLR4 IRF3 ARHA MYD88 PMC9646812__F4 Transcriptomic profiling analysis to identify genes associated with PA biosynthesis and insolubilization in the late stage of fruit development in C-PCNA persimmon ALDH2 PDC CS PMC3219972__F3 Effect of carbon exchange and reversibility constraints CPD TNLG7C ADA PMC7484971__F8 KEGG enrichment graph: miRNA-4534 is involved in the FOXO signaling pathway STAT3 EGF KLF2 IL10 EGFR SMAD4 BNIP3 IL7R PTEN SKP2 ATG12 INSR CDK2 ATM GOPC NLK MDM2 REL PMC5664079__F3 PDK1 and the Salvador/Warts/Hippo (SWH) pathway LAT PMC2094129__F2 Respective balance between Gi- and Gs-dependent signalling pathways and their roles in the modification of FcARI-mediated mast cell degranulation LPA SYK BTK FYN LYN PMC5664079__F1 Major signaling pathways in chemoresistance and PDK1 implication MTDH CAMKK2 PMC7110753__F3 Hypothesized dauer signaling during N NCR1 IGF1 SGK1 PPM2C PTEN SKI ADA PMC10779870__F11 KEGG TNFA signaling and its association with the PI3K-AKT signaling pathway TRAF3 TNF TRAF2 PMC4240841__F1 Proposed model of Ostf1 in fishes BMP4 ROCK1 GCK PMC7956578__F2 Impact of hypoxia pathway proteins on immune cells and cancer stem cells, and their impact on the development of the tumor EGF HGF TNF PMC10779870__F13 Proposed molecular effects of fucoxanthin through modulation of genes and proteins of the PI3K-AKT signaling pathway in TNF-Alpha-stimulated MDA-MB-231 and MDA-MB-468 cells HRAS EIF4B TIRAP EIF4EBP1 FOXO1 ARHA PDK2 IRS1 MAPK3 PMC4714660__F4 Cell death pathway in tumor cells COMP TLR3 PGAM5 MLKL CYLD FADD PMC7218030__F3 Partial action pathways of H2S donors and their derivatives on TNBC CASP9 FOXQ1 CASP3 MTOR CTNNB1 PMC6400837__F1 Notch pathway promotes drug resistance by regulating cancer cell survival, glycolytic switch and cancer stem cells STAT3 ABCC1 HEL-S-133P HK2 DLL4 PDK2 MYC RBPJ HEXA IGF1 JAG2 BCL2 ENO1 HEL-S-87p PFKM HES1 PMC8213345__F3 Interplay of Forces and the Immune Response for Functional Tendon Regeneration COL1A1 CFTR TNMD CTNNB1 PMC3362209__F1 RIP-1 in programmed necrosis TAB3 PROC CYLD FADD PMC5511947__F1 The downstream signaling cascade initiated by a hypoxic microenvironment CDH2 BMI1 CD44 EPCAM SOX2 TWIST2 ZEB2 ABCG2 CXCR4 TWIST1 PMC7349551__F1 Wingless and Int-1 (WNT)/Beta-catenin signaling pathway LRP5 LRP6 CTNNB1 PMC11715087__F9 Working model summarizing key conclusions from this study HAP1 PHGDH NAXD PMC9266842__F2 Immunomodulatory Properties of PI3K/AKT/mTOR and MAPK/MEK/ERK Inhibition Augment Response to Immune Checkpoint Blockade in Melanoma and Triple-Negative Breast Cancer EGFR PTEN IGF1R MTOR SKP2 PMC9664149__F6 Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation CRP NOG GPX1 MPO PMC3393131__F1 Wnt/Beta-catenin signaling in T cell immunity and cancer immunotherapy BCL9 PROP1 APC LRP5 LRP6 TEF SATB1 CTNNB1 PMC4166520__F1 ATX-LPA Receptor Axis in Inflammation and Cancer CDCA2 LPA SI ARHA PMC9664149__F8 Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation CRP ACE2 MPO PMC6433792__F1 Phosphodiesterases (PDEs) in the pituitary gland: After stimulation of somatotroph cells via GHRH, the G protein coupled receptor is activated, which causes a conformational change of the receptor GHRH AIP PDE4D PDE4A PMC3573097__F7 Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma EGFR RIOK2 RIOK1 PMC3949429__F2 Two major signaling pathways activated by HBV and HCV in hepatocarcinogenesis BAD IGF1 APC GRB2 SRC IRS1 CTNNB1 PMC9297740__F1 PARP Inhibitors in Glioblastoma and Perceiving Challenges as Well as Strategies for Successful Clinical Development MSH6 MSH2 MGMT PMC4083841__F1A Beta-Thalassemia and Polycythemia vera: targeting chronic stress erythropoiesis EPOR EPO PMC9550229__F2 Screening and validation of nickel ion cytotoxicity biomarkers based on transcriptomic and proteomic technology CRK CSF1 CAD LAT VAV2 PMC4674888__F9 Development WNT signaling pathway Part 1 RBX1 APC GSK3B TCF4 SKP2 CTNNB1 PMC4674888__F8 Development Hedgehog Signaling which is the top scored pathway map in MetaCore enrichment analysis results CDON BOC DHH IHH NUMB SKP2 KIF27 CTNNB1 ADRBK1 RBX1 SPOP SAP18 SUFU PTCH1 DISP1 SHH CDC37 GAS1 GLI3 PMC8047077__F7 IFI6 mediated inhibition of HBV replication and gene expression STAT1 STAT2 PMC5880536__F2 Gut microbiota and IBD: causation or correlation? IFNG IL16 AHR TNF IL1B PMC4132784__F7 Mechanism by which the PTEN-PI3K-AKT-MDM2 signaling axis exerts control over HIF1A degradation in cytoplasm under hypoxic conditions via the MDM2 E3 ligase and 26 S proteasome RBX1 PI3 PTEN MDM2 VHL PMC11008728__F2 Fine-tuning tumor- and allo-immunity: advances in the use of immune checkpoint inhibitors in kidney transplant recipients CXCL9 CXCL11 CD80 APC CXCL10 PMC8198195__F5 Resolving the Contradictory Functions of Lysine Decarboxylase and Butyrate in Periodontal and Intestinal Diseases L2HGDH HBD PMC11490609__F4 MAPK pathway activation in zccs1703 CDK6 FRS2 SOS1 NF1 FGFR1 BRAF KDR GRB2 VEGFA CCND1 CDK4 PMC10779157__F3 SHP-1-mediated inhibition of the JAK/STAT signaling pathway STAT1 STAT2 EPOR EPO JAK1 TYK2 PMC8147772__F3 Control of Macrophage Inflammation by P2Y Purinergic Receptors STAT1 TLR4 MYD88 PMC8147772__F2 Control of Macrophage Inflammation by P2Y Purinergic Receptors ADAM17 TLR4 MYD88 PMC3602989__F2 Leptin and cancer: Pathogenesis and modulation STK11 LEPR CRTC2 PMC8294041__F8 Cancer Preventive and Therapeutic Potential of Banana and Its Bioactive Constituents: A Systematic, Comprehensive, and Mechanistic Review BAX ATF3 EGF EGR1 EGFR GRB2 PMC5739444__F7 SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation RHO SIRT2 PMC6585406__F1 OAS/RNase L pathway OASL RNASEL OAS3 OAS1 OAS2 PMC8534193__F1 Emerging Influences of Alpha-Fetoprotein in the Tumorigenesis and Progression of Hepatocellular Carcinoma AFP ZHX2 PMC6888217__F3 Extracellular ADO on subsets of macrophages CD80 CD163 CD68 PMC6888217__F1 Extracellular and intracellular (canonical and non-canonical) adenosinergic pathways PIR ENPP1 ADA PMC3196095__F6 Proposed model NR1C1 TLR4 CD14 LBP PMC2605641__F2 Nrf2-ARE Pathway: An Indicator and Modulator of Oxidative Stress in Neurodegeneration GCLM NQO1 GCLC PRX PMC9058032__F5 Ba Zhen Tang Delaying Skin Photoaging Based on Network Pharmacology and Molecular Docking TH MMP14 SELE LIF BIN1 SOCS3 TRAF3 TNF DAO POR NOD2 FES HEL-S-11 PROC TRAF2 PMC4125705__F4 Phenylpropanoid biosynthetic pathway in Ocimum sps CAD CS PMC3610375__F1 The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus IL10 IL4 PMC3969997__F7 The hypothetical signaling pathway in pathological angiogenesis regulated by interactions of activated VEGFR2 and EPOR STAT3 EPOR VEGFA PMC2542903__F6 Proposed EphB2 signaling network ABI2 SHB USP15 NEDD4 CYFIP1 ABL2 DDR2 DOCK4 UBB PMC9226676__F2 Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications PMC5766282__F12 Novel Role of the Nociceptin System as a Regulator of Glutamate Transporter Expression in Developing Astrocytes JAK3 MTOR PMC2995293__F2 Immune and central nervous systems interact and contribute to the etiology and pathophysiology of cytokine-induced depression CRP CRH WAS IL2 BDNF IL1B PMC12165645__F1 Simplified overview of ISGs and their actions in kidney diseases ISG20 TEC IFIT1 ISG15 OAS1 PMC7511443__F4 MC5R signaling pathways STAT1 PLIN1 PMC12165645__F2 Therapeutic agents targeting ISGs ISG20 IRF9 IRF3 IRF7 ISG15 PMC4153031__F2 The hypothetical estrogen-induced signaling pathway in neurons MAP1B APP PMC8866817__F4 CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer FAS TNF FADD PMC3386525__F3 The signalling transduction pathways involving the tuberous sclerosis proteins, hamartin and tuberin RHEB RHO MTOR EIF4E PMC7916982__F9 Iso-Alpha-acids can exert anti-inflammatory activity by inhibiting the NF-kB pathway by acting on several kinases involved upstream and downstream of the signal transduction SYK BTK MAL BMX TNF IL1B MYD88 PMC7933481__F1 Anti-inflammatory effects of increased global SUMOylation in the intestine CXCL9 CXCL12 IF2B1 CCL11 NLRP3 IL27 CXCL16 IL17A IL6 CCL5 CCL20 PMC2696288__F7 Protein Acetylation Microarray Reveals NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis PC PCK1 SIRT1 PMC4464175__F5 Lipid biosynthetic pathways and interactions of phospholipid synthases and proteins involved in cell division LPA PGP LTA DGKA PSD DGKB LPP PMC6036613__F3 NFKB pathway induced by LaW37 in Caco-2 cells CD40 ZAP70 WNK1 EGF LTA TGFA LTBR CARD11 RELB TNF NGF MAP3K7IP1 PLCG2 RELA LCK PMC3075645__F8 DNA damage-triggered activation of SAPK/JNK at late times following cisplatin treatment XPA ATR BRCA2 ATM RHO XPC PMC6722208__F1 Circadian regulation of hepatic gluconeogenesis illustrates an example of bi-directional regulation between clock genes and metabolism FOXO1 NAMPT PCK1 SIRT1 PMC7140515__F1 Crucial signaling pathways in CCA metabolism HDAC3 UCP2 PDHA1 FOXO1 PTEN SIRT2 SIRT1 PMC5343750__F1 Are Circulating MicroRNAs Peripheral Biomarkers for Alzheimer’s Disease? RAN AGO2 DROSHA PMC10583183__F11 Mechanism that HRF prompts pyroptosis via CaSR/NLRP3/caspase1 signaling pathway under MI/R conditions CASR GSDMD NLRP3 PMC3593087__F1 Pro-osteoblastogenic signal transduction by insulin and IGF1 receptors IGF1 PTEN GRB2 PMC3593087__F3 Cross-talk between insulin/IGF-1, BMP2, and Wnt signaling pathways NR1i1 TF SMAD1 DKFZp781O1323 APC SMAD4 PTEN IBSP RUNX2 IRS1 CTNNB1 ALK IGF1 BMP2 GRB2 PMC7180223__F1 Gene ontology (GO) analysis of LOAD risk factors reveals the enrichment of genes in the trafficking pathway HESX1 ADAMTS4 HLA-DRB1 ALPK2 SPI1 CR1 TREM2 APH1B NYAP1 CLU CD33 CLNK WWOX MS4A2 SLC24A4 SCIMP SORL1 ZCWPW1 APOE INPP5D BIN1 CASS4 PTK2B EPHA1 ABI3 FERMT2 PICALM CD2AP KAT8 ADAM10 MS4A6A PMC2945784__F2 Cancer signaling pathways affected within the tumor RPTOR EGF RAF1 SOS1 NRTN EGFR PDGFA PTEN MTOR EIF4E HRAS NKX3-1 RB1 SOST PDPK1 RET PMC10556387__F2 Neuroprotection targeting to signal transduction of apoptosis, necroptosis, and autophagy in ischemic stroke RIPK3 BAX TRPM7 MLKL ATG14 RIPK1 FADD PMC10556387__F1 Neuroprotection targeted to oxidative stress and induced mitochondrial dysfunction and ferroptosis in ischemic stroke LOX KEAP1 GPX4 LPCAT3 FACL4 PMC3356304__F6 Personalized Pathway Enrichment Map of Putative Cancer Genes from Next Generation Sequencing Data EGFR TP63 PTEN PMC4055840__F5 Hypothetical model illustrating possible molecular mechanisms underlying the action of the glucocorticoid receptor in the excitation-inhibition balance in NPCs CORT EGR1 BDNF PMC8445921__F5 Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis TH ASL PMC4344782__F11 Overlapping Alzheimer-related protein association network of AD-iPS5 neurons and of AD-iPS26B neurons COX7B NDUFB6 NDUFB5 NDUFV2 GSK3B COX7C CYC1 NDUFA7 ATP2A2 NDUFAB1 NDUFS4 COXFA4 COX6A1 NDUFA3 NDUFB7 APP NDUFB3 NDUFC2 HSD17B10 SNCA SDHA COX7A2 HEL-S-162eP CALM1 NDUFA2 PMC8543024__F3 Adenomyosis pathogenesis: insights from next-generation sequencing GRB2 KRAS PMC4344782__F10 Alzheimer-related protein association network in AD-iPS26B neurons COX7B NDUFB6 NDUFB2 NDUFB5 NDUFV2 NDUFS5 GSK3B NDUFA6 COX7C CYC1 NDUFA7 ATP2A2 NDUFAB1 NDUFS4 COXFA4 COX6A1 NDUFA3 NDUFB7 UQCRH APP NDUFB3 NDUFC2 SNCA NAE1 UQCRC1 SDHA COX7A2 UQCRFS1 HEL-S-162eP CALM1 NDUFA2 COX6B1 PMC3140692__F3 Hypoxia regulates other critical pathways that impact tumor progression in a HIF-independent fashion RHEB TSC2 PML EIF2A EIF4E PMC5524075__F7 Interleukin (IL)‐13RA1 in myocardial metabolism FH APC MAL PC CS PMC3757391__F1 Maintainance of DNA Methylation DNMT3B ATR TET1 ATM MBD4 TDG FADD PMC9243104__F7 Graphical abstract of WASp:RPA alliance in genome stability TOPBP1 ETAA1 WAS PMC5817862__F2 TKIs inhibit TKs-mediated signaling pathway PTEN GRB2 MTOR PMC8081290__F3 Integrated working model of key metabolic signaling axes in macrophages (Mфs) during ischemic organ injury and repair FAS NLRP3 CD36 TLR4 MTOR IL1B MERTK CIT PMC8944338__F4 Multi-protein complexes contribute to the Stimuli-Sensing Channels intracellular signaling pathway TRPA1 CLCN3 C2 TRPM5 CLCN7 TRPV1 STOML3 TTYH2 TTYH1 SLC17A3 TTYH3 PMC8944338__F3 Protein-protein interaction network for the AGE-RAGE pathway PLCD3 STAT3 PIK3CA PIK3CD PIK3R2 SMAD2 PIK3R1 PRKCZ SMAD4 MAPK9 MAPK8 CCL2 MAPK3 MAPK14 STAT1 VEGFB PRKCA THBD MMP2 MAPK12 MAPK1 AGTR1 IL1A VEGFA TNF HRAS EDN1 BCL2 MAPK10 VCAM1 CYBB CDC42 VEGFC PLCB4 TGFB1 MAPK11 MAPK13 PIK3R3 AKT3 NOX4 PRKCB TGFBR1 TGFBR2 PLCG1 COL1A1 PRKCE F3 CCND1 IL1B BAX EGR1 COL1A2 PIM1 SELE VEGFD NFATC1 IL6 KRAS RAC1 PLCE1 AGER NFKB1 RELA CASP3 PMC5362340__F1 Kinase signaling and targeted therapy for primary myelofibrosis CDC2 STAT3 MPL HEL-S-99n AURKA C13orf34 PAK1 ARHA HCTP4 PMC3258586__F1 PI3K pathway activated by EGF-stimulated EGFR or by the constitutively activated EGFRvIII EGF EGFR PTEN MTOR SRC PMC10979751__F3 Macrophages in osteosarcoma cell proliferation and metastasis STAT3 EGF TGFA ARG1 PMC10957566__F2 Protective effect of the Notch signaling pathway on B cells under irradiation exposure PAX5 SI PREB FURIN PMC8169418__F1 Effect of COVID-19 on NFKB and Neurological Manifestations of Disease TMPRSS2 TLR3 TLR7 ACE2 PMC9511411__F5 Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy COPA TREX1 PMC9511411__F4 Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy TBK1 STAT1 STAT2 IRF3 JAK1 TYK2 PMC8984481__F1 Escaping Death: How Cancer Cells and Infected Cells Resist Cell-Mediated Cytotoxicity SHARPIN RIPK3 BAX FAS CASP8 TRADD MLKL RIPK1 TNF TRAF2 FADD PMC9511411__F7 Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy FCGR2B MYSM1 TREX1 DNASE2 PMC4028619__F1 Linking metabolism and epigenetic regulation in development of hepatocellular carcinoma HEL-S-182mP HEL-S-61p PMC9669583__F3 8p11 myeloproliferative syndrome: Genotypic and phenotypic classification and targeted therapy STAT3 STAT1 TSC2 FRS2 FOXO1 GRB2 PMC3411062__F1 Network pathways analysis of molecules identified in T-cells that are involved in LFA-1/ICAM-1 signaling BMPR2 BCOR SKIL TGFA FLT3LG SPSB1 MAP2 RBPJ MLLT3 MCM7 SMURF1 CDKN1A IDO1 JAG2 CDKN3 MAP2K1 SMURF2 SPRY1 CD6 PMC3075510__F9 Phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3 (GSK3) signalling is required for expression of a subset of interleukin-10 (IL-10) inducible genes STAT3 ARNT2 SOCS3 PMC5449086__F8 Schematic model of the regulatory role of ADAR1 in liver homeostasis MAVS IRF3 IL6 CCL5 CCL2 PMC8797391__F9 Bioinformatics analysis of BUB1 expression and gene regulation network in lung adenocarcinoma GAL FER MAL PMC6280705__F1 General eukaryotic translation initiation pathway ELF2 EIF5 EIF5B EIF2A ELF5 ELF3 EIF4E PMC6527392__F10 Atypical PKCs control actin cytoskeleton via Cofilin activation SSH2 EGFR SSH1 PTEN PMC6892198__F1 Retinoic acid (RA)-signaling pathway CYP26B1 ADH7 CYP26C1 ALDH1A3 HEL-S-53e RBP4 RDH10 RDH5 ALDH1A2 CYP26A1 PMC10135819__F2 Diagram illustrating RET and RET-regulated NAD+-dependent sirtuin signaling pathway as a contributor and potential therapeutic target for aging, age-related diseases, and ischemic stroke NDUFS3 RET PMC8201404__F2 GIMAP Family Proteins: An Incomplete Puzzle RHEB ZAP70 TSC2 TSC1 LAT JAK3 GSK3B GRB2 MTOR JAK1 LCK IAN4L1 PMC7866155__F1 Targeted Neoadjuvant Therapies in HR+/HER2−Breast Cancers: Challenges for Improving pCR CDK6 BCL2 PTEN NODAL MDM2 CDK4 PMC7438278__F7 Working model for induction of cardiomyocyte necroptosis by Cops8 deficiency RIPK3 CASP8 MLKL BCL2 RIPK1 PMC6121276__F2 Catabolic and pro-inflammatory signaling in osteoarthritis ACAN SMAD1 DKFZp781O1323 SMAD2 FGFR1 SMAD4 MMP2 MMP9 CTGF COL2A1 IL1B FGF2 PMC11953998__F22 Design strategies for nanodrugs targeting the mitochondria and lysosomes NPS CUTA FAP PMC3977945__F3 Ubiquitination-mediated regulation of the core Wnt/Beta-catenin pathway components HECTD1 APC LRP5 LRP6 CTNNB1 USP14 SMURF1 RNF43 USP15 ZNRF3 SMURF2 RNF148 CYLD PMC3977945__F2 Simplified phosphorylation-mediated regulation of the core Wnt/Beta-catenin pathway components HIPK2 APC dik LRP5 LRP6 NLK TNIK CTNNB1 PMC3977945__F1 Simplified Wnt/Beta-catenin pathway APC LRP5 LRP6 CTNNB1 PMC5381727__F2 Roles of Caspases in Necrotic Cell Death NLRC4 HMGB1 NLRP3 IL16 AIM2 IL1B PMC7264424__F8 Calcium signaling pathway TRDN PLN HRC BCR STOM MCU CP PMC8297384__F1 Regulatory T Cells in Epicutaneous Immunotherapy for Food Allergy ICOS CD80 CXCL1 CD46 CXCL2 SOCS3 CD163 LAG3 PMC5826825__F2 Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development OFD1 PSCA DSC2 PMC8074600__F2 Dysregulation of Multiple Signaling Neurodevelopmental Pathways during Embryogenesis: A Possible Cause of Autism Spectrum Disorder SUFU PTCH1 DHH SHH IHH SMO GLI3 PMC8074600__F1 Dysregulation of Multiple Signaling Neurodevelopmental Pathways during Embryogenesis: A Possible Cause of Autism Spectrum Disorder CDH8 BCL9 APC LRP5 LRP6 PMC3589553__F3 Regulatory mechanisms for the Hippo pathway LATS1 PATJ AMOT APP SCRIB AJUBA PALS1 RHO PMC8339349__F7 lncRNA H19 facilitates the proliferation and differentiation of human dental pulp stem cells via EZH2-dependent LATS1 methylation LATS1 EZH2 PMC6134813__F4 Pathways Involved in Ovarian Epithelial Cancer CXCL9 GNGT1 PTGER3 CXCL13 NUF2 PDYN CENPE CXCL10 CXCL11 FOXM1 SPC25 GPR17 MCM10 NPW CDCA8 CNR1 SKA1 PMC11953998__F24 Synthesis process for the polymer DBD and the formation of NP-DBD nanoparticles TBK1 CGAS PMC3418849__F10 TrkA signaling pathway CRK NGF BAD MAP2K4 FRS2 MAP2K6 FOXO1 MAP2K1 MAP2 GRB2 MTOR SRC PMC4209203__F10 Contrasting roles for histone 3 lysine 27 demethylases in acute lymphoblastic leukemia SUZ12 EED FBXW7 MAML1 EZH2 JARID2 SET NOTCH1 PMC4859987__F1 Terpenoid indole alkaloid pathway IPP INMT PMC2989631__F1 DNA damage response (DDR) pathway HERC2 BRCA1 RNF168 RNF8 ATM MDC1 PMC11055915__F4 Mitochondrial quality control regulates cell death induced by copper and iron FAS TRADD GPX4 MLKL MFN1 LPCAT3 FACL4 RIPK3 DLAT GSDMD NLRP3 PDC MFN2 FES RIPK1 FDX1 PMC8632002__F2 Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19 TASL IRF7 TLR7 SLC15A4 MYD88 PMC11187369__F4 Druggable toll-like receptor (TLR) cascades BTK TIRAP TLR9 TLR8 TLR7 EEA1 MYD88 PMC4376477__F1 Neuronal aggregates: formation, clearance and spreading HSF1 PMC7177938__F4 Gene-Ontology (GO) term enrichment and pathway term network analysis of DEGs shared by ADJ versus PRE and ATT versus PRE lists (1928 DEPs) HEL-S-11 HP RHO PROC POLE PMC7865703__F2 STAT3 pathway activation represents a focal point of tumorigenesis and immune escape CD80 EGFR BCL2 FOXP3 CCL2 PMC10216286__F1 The TRAIL apoptosis pathway BAX FADD PMC7381302__F1 Extrinsic apoptosis execution C6 BAX BAD HEL-S-62p C9 BCL2 FADD PMC4618842__F1 Pathogenesis of Muscle Wasting in Cancer Cachexia: Targeted Anabolic and Anti-Catabolic Therapies IGF1 ELF2 MTOR EIF4E PMC10216286__F2 TRAIL resistance BAX FADD PMC5615369__F1 Novel aspects of tumor biology and translational approaches using zebrafish models RAG2 TWIST2 GATA3 PMC7191626__F1 Enzymatic cascade involving the renin-angiotensin system, key receptor systems, and biological effects ACE2 PMC6997470__F2 PAMPs exposure regulation in response to environmental signals CCL3 TLR9 NOD2 ACE2 IL1B PMC3329953__F8 mTOR pathway in aging RHEB MLST8 TSC2 TSC1 GSK3B EEF2 MTOR EIF4E PMC11554632__F1 Outline of force-sensing proteins in cardiovascular system PIEZO1 MTOR CCND1 CDK4 PMC9013808__F3 cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal AKAP7 PMC6770909__F1 Redifferentiation of thyroid cancer PTTG1 TSHR PAX8 BRAF PTEN MTOR PIGU TTF1 RET PMC3218743__F2 Inflammation in the gouty joint ATR NLRP3 MYD88 PMC6780401__F3 Impacts of mutations in the TGFB signaling transduction components contribute to PDAC development BMPR2 SMAD1 TGFBI ADM WAS KLF10 KRAS TGFBR1 PMC4266469__F1 Schematic demonstrating the effects of AMPK signaling in stroke BAD F2 PMC6447777__F2 Candidates of miRNA-based therapy against perinatal hypoxic-ischemic brain injury PTGDR REST TLR4 MSC PTEN ARHA IRAK4 FGF2 PMC7501671__F8 EMfC action in amelioration of inflammatory response and autophagy pathway during anti-hepatic steatosis in HFD-induced obesity mice FAS ATG12 ATF4 MTOR EIF2A PMC8498116__F1 Targeting the Integrated Stress Response in Cancer Therapy ELF2 ATF4 EIF2A PMC2635018__F1 Amino acid transporters and nutrient sensing mechanisms RHEB TSC2 TSC1 IRS4 PTEN IRS1 PMC8221367__F1 Canonical Wnt Signaling Pathway and Tcf1 APC GSK3B LRP5 LRP6 AXIN2 CTNNB1 PMC6050436__F5 MapMan overview of general metabolism for the metabolites and proteins/transcripts of Quercus ilex GIP OMA1 CIT PMC2805685__F11 Reconstruct part of KEGG pathway by our method HSF2 STAT1 RUNX1 ALG10 E2F3 EGFR BCL2 YY1 ATF2 PMC4829595__F3 Representation of the cross talk among different pathways under water-deficit conditions TH SNRK LIPN PMC6520274__F1 Hydrogen sulfide intervention in cystathionine-Beta-synthase mutant mouse helps restore ocular homeostasis CS HEL-S-61p MTR PMC6616371__F3 Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing CDC42 DKK1 APC ROR2 GSK3B RYK RHO LEF1 PMC6813538__F8 Action of EC-7072 targeting the BCR signaling pathway in CLL cells CD79A BTK BCL10 PLCG2 BCL2 CD19 LYN PMC1785270__F6 A model illustrating the positive and negative regulation of PanK2 activity PANK2 PANK3 PANK1 CPT2 PPAN PMC7090043__F2 Context is everything: extrinsic signalling and gain-of-function p53 mutants HSF1 ARHA MDM2 HDAC6 PMC6616371__F4 Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing RAF1 GRB2 PMC5108756__F2 Inhibition of the complement system by pathogenic fungi GPD2 HEL-S-62p PLG PMC8401727__F5 Physcomitrium patens Infection by Colletotrichum gloeosporioides: Understanding the Fungal–Bryophyte Interaction by Microscopy, Phenomics and RNA Sequencing HEL-S-11 ERG PMC7947196__F1 Microglial metabolic programming and immune functions in AD HIF1A MTOR IL1B PMC1351030__F8 Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras HRAS EGR1 KLF5 CCND1 PMC11082748__F4 Graphical representation of the CREB signaling pathway downregulated in the control group (see Figure 3A) MAPK1 GTF2B RAF1 SHC1 RPS6KA1 CREBBP CAMK4 EP300 MAPK12 GRB2 TBP PMC3928130__F2 AMP-activated protein kinase (AMPK) beyond metabolism RAD50 MRE11A H2AX CDK2 ATM PMC3928130__F4 AMP-activated protein kinase (AMPK) beyond metabolism RHEB ATM SESN2 PMC11082748__F5 Genes (N = 21) detected by IPA as involved in the neuroimmune pathway were entered into a representation using the GeneMANIA algorithm ICAM2 MEFV HMGB1 IFNGR1 PYCARD MAPK13 TICAM2 PIK3R1 CTSS B2M FOS MYD88 CSF3R MAPK14 TYROBP CX3CR1 ACVR1 FPR1 MAP2K3 CSF1R HMGB2 CYBB ICAM4 PMC4019832__F2 Activation, signalling and targeting of ErbB receptor family members JUN PTEN GRB2 MTOR MYC FOS PMC7504480__F1 eATP/P2X7R Axis: An Orchestrated Pathway Triggering Inflammasome Activation in Muscle Diseases HMGB1 NLRP3 TLR4 IRAK1 TRAF6 IRAK4 IL1B MYD88 PMC3334466__F1 Duo/Cdc42 pathways CDC42 PAK1 LIMK1 PMC4287105__F3 Example of difference between LW and MS at fetal gestational age 110: pathway of Gluconeogenesis HEL-S-133P HK2 MPC2 PCK2 PGAM2 DLAT ALDOB PFKP HEL-S-162eP PC DLD ENO1 GCK PKLR PMC3928130__F1 AMP-activated protein kinase (AMPK) beyond metabolism TSC2 YY2 PMC8500332__F8 n-butyrate alters the RAP1 signaling pathway in the endometriotic epithelial cells CAD RAD1 LAT PMC8743870__F8 Triaging Down the 2021 Chest Pain Guidelines CAD PMC11811495__F3 Example of network visualization from the KEGG Pathway database for the “Wnt signalling pathway” (https://www.kegg.jp/pathway/hsa04310), analysed using Orthoweb MCC FZD10 RYK SENP2 NR1C2 APC2 PMC5527809__F2 Interaction network and subcellular localization of differentially regulated genes by dasatinib in K562 cells ARHH HHEX CD69 PDE4DIP IKZF4 SOCS2 SOCS3 HECW2 PHLDA1 MYC XBP1 ATF3 ERMAP MAFF IER2 CISH PMC6463957__F5 Hub genes and module analysis of the PPI networks ACTN1 THBS1 COL1A2 TIMP1 HEL-S-53e P4HA3 SPARC COL10A1 COL3A1 ADH7 CYP2C18 SERPINA4 MUC5AC ALDH1A3 MUC6 UGT2B15 COL1A1 COL18A1 ALDH3A1 COL4A2 B3GNT6 MUC1 Meflin GCNT1 PMC8992553__F2 Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications BAX DIABLO FADD PMC7418797__F1 Therapeutic mechanism related to natural products HRAS SMAD2 APC SMAD4 HEL-S-28 CTNNB1 PMC4276934__F2 Reactome mapping of differentially-expressed genes IFNGR1 IRF9 IFI30 PML IRF1 IRF3 IRF7 PTPN21 IRF4 IRF8 IFNG IRF6 MT2A SP100 IRF2 JAK1 PMC4410070__F1 Accelerated Vascular Disease in Systemic Lupus Erythematosus: Role of Macrophage VCAM1 MIF PMC7770493__F3 cAMP signalosomes at the endoplasmic reticulum, nucleus, and centrosome PLN PDE3B AKAP6 AKAP8 PDE4D AKAP7 AKAP9 PDE4A PMC7770493__F2 Mitochondrial cAMP signalosomes CHCHD3 BAD STAR MTX2 RAB32 PBR SRC PDE4A PMC7770493__F1 Plasma membrane and primary cilium cAMP signalosomes AKAP5 NHERF1 GPR161 PCM1 INA CFTR AKAP9 PMC8379492__F9 Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies TG HMGCR FOXO1 PMC9179518__F1 Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function VEGFC CD36 NOX4 PMC8021790__F2 Regulatory network model for alanine, aspartic acid and glutamate metabolism pathway(enzyme, posttranslational modification, activate, inhibition, catalysis, reaction, and combine DLG2 GNAI3 RAF1 SHC1 SOS1 VAMP2 HEL-S-62p PDE6C GAD1 STX8 PDE4B GNAS EPHB2 PLCG1 PI3 F2 AP2A1 PDE4D GAD2 ATF4 SRC RAPGEF5 GNB5 PLA2G4E CD55 HRAS NRG1 PRKACG PLCB1 GNA11 SNAP25 ASNS PRKG1 PMC7198709__F1 Biosynthetic pathways of NAD+ in mammalian cells includes de novo, Preiss–Handler, and salvage pathways, and the salvage pathway is the main source of NAD+ NRK NAPRT NAMPT PMC8815517__F1 mTOR Signaling in Kidney Diseases RHEB MLST8 TSC2 TSC1 GSK3B PTEN DEPTOR PMC4156761__F8 Schematic model shows the downstream signaling pathway of PIP5K1A and the effect of ISA-2011B inhibition PIP5K1A CDC2 PTEN SKP2 PMC4065255__F1 Core components of the insulin-like signaling pathway in C SGK1 PMC11525629__F3 MAOs in the suppression of antitumor immunity IL13 PTCH1 IL4 SHH PMC5866357__F3 General overview of metabolic pathways in healthy ECs FAS ASL GLS SORD F2 HEL-S-162eP FASN CPT1A PMC4038158__F3 Signaling pathway initiated by Edn1-induced Ednra signaling PLCB4 EPHA2 GREM2 NOTCH2 HAND2 MEF2C DLX6 EDN1 EDNRA GNA11 GSC PLCB3 HAND1 GNA13 PMC11525629__F1 Signaling pathways activated by mito-DAMPs CGAS MAVS NLRP3 TLR9 AIM2 IRF3 IRF7 MYD88 PMC6923371__F3 Schematic illustration of a causal network in the Ingenuity Pathway Analysis (IPA) environment MMP7 HGF VEGFA PMC9477818__F1 Antimicrobial potential of a ponericin-like peptide isolated from Bombyx mori L. hemolymph in response to Pseudomonas aeruginosa infection DDC FADD PMC6468149__F1 The Hippo signaling pathway-YAP/TAZ in human endothelial cells LATS1 MOB1A MOB2 ANKRD1 THBS1 AXL AMOT AMOTL2 AREG PMC8987999__F2 Emerging diabetes therapies: Bringing back the Beta-cells GLP1R IGF1 HEL57 GSK3B IGF1R IRS1 PMC8165279__F1 Dimming the Powerhouse: Mitochondrial Dysfunction in the Liver and Skeletal Muscle of Intrauterine Growth Restricted Fetuses GOT2 FH HEL-S-133P IDH3B LDHB CS MPC1 PDK3 PDK2 MPC2 PDK4 SUCLA2 OGDH HEL-S-5 PC HEL-S-32 MDH2 COXFA4L2 PMC3995556__F9 BTC-stimulated IL-8 production and bio-behaviors of lung cancer cells EGFR BTC GRB2 MTOR PMC12103044__F4 Triggers and pathogenesis for pathological scar formation SMAD2 TAB3 SMAD4 IRAK1 HIF1A ARHA SMURF2 CYLD MYD88 PMC5288206__F6 Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas SLC12A1 WNK1 CCND1 PMC6787567__F3 Involvement and regulation of lncRNAs in M1‐like macrophage polarization HNRNPAB HNRNPL IL3 IL4 IL6 IL5 TRAF6 SET MYD88 COX2 TLR4 IL18 IL2 IL7 JAK1 SIRT1 PMC6787567__F2 Involvement of lncRNAs in monocyte/macrophage development and M1/M2 switch IFNG ACVR1B MARCO PMC9207355__F7 CEMIP promotes extracellular matrix‐detached prostate cancer cell survival by inhibiting ferroptosis KEAP1 CEMIP SLC7A11 PMC6923546__F5 Schematic representation of the proposed model: blocking PRMT5 promotes lung cancer cell death via Akt/GSK3B signaling pathway induced by resveratrol GSK3B PMC3380376__F3 Relationship between binding of ligands to the pattern recognition AGE receptor (RAGE) and inflammation, gene expression, oxidative and nitrosative stress, and damage to the macro- and microvasculature HMGB1 EGR1 ARC NCL PMC6533683__F1 mTOR signaling pathway regulated autophagy and EMT SMAD2 GSK3B HEL-S-28 MTOR ATG5 RAC1 CTNNB1 PMC10511167__F7 MiR-143/145 cluster induced by TGFB1 suppresses Wilms’ tumor 1 expression in cultured human podocytes WT1 SMAD2 SMAD4 PMC6533683__F3 P53 signaling pathway regulated autophagy and EMT ATG10 ULK1 PTEN ZEB2 MTOR PMC6533683__F2 Beclin-1 signaling pathway regulated autophagy and EMT WNT1 PMC6533683__F5 Integrin signaling pathway regulated autophagy and EMT EGFR HEL-S-28 MTOR CTNNB1 PMC6533683__F6 WNTs signaling pathway regulated autophagy and EMT TWIST1 CTNNB1 PMC6533683__F8 TGFB signaling pathway regulated autophagy and EMT STAT3 SMAD2 ATG5 PDE4A CTNNB1 PMC7290055__F4 Co-ordinately up-regulated genes of NF-Kappa B signalling pathway in HIV-H LTB IL10 LTA TRADD TIRAP LAT BLNK ATM EDAR CYLD BIK PMC6858495__F3 pRB/E2F pathway dysregulation leading to unrestricted CASP3 gene transcription CDK6 CASP3 CDK4 PMC6769035__F1 Tumor microenvironment shapes NK cell metabolism and effector functions FBP1 MTOR PMC6858495__F7 Activation of PC-3 by PAC-1 and its derivatives via chelation of labile inhibitory zinc BRAF PMC5927694__F1 A conserved parallel pathway for telomere protection ATR ATRIP ATM PMC7439780__F6 Protein-protein interaction (PPI) regulatory network of proteins involved in the pentose phosphate pathway (PPP) HEL107 RPE HEL-S-304 DERA HEL-S-87p PMC8036323__F5 Cooperation of autophagy with phagocytosis in microglial activation TREM2 COX2 CD36 ULK1 ATG5 PMC3089810__F2 Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy BTK LYN GRB2 SRC BIK PMC9011276__F2 Narrative review of the role of the Notch signaling pathway in rheumatoid arthritis DLL4 NOTCH2 NOTCH3 DLL3 NOTCH1 PMC6389150__F5 Model of NDV V protein regulating apoptosis in DF-1 cells HEL-S-114 BAX BCL2 PMC9334657__F2 Connecting Metabolic Rewiring With Phenotype Switching in Melanoma FAS ACSL3 CD36 SCD PMC5347713__F7 Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway TIRAP TLR4 TRAF6 CCND1 MYD88 PMC11206024__F3 TLR4 signaling pathway TBK1 TIRAP IRF3 TRAF3 TRAF6 MYD88 PMC8781800__F3 Current Aspects on the Pathophysiology of Bone Metabolic Defects during Progression of Scoliosis in Neurofibromatosis Type 1 NF1 SMAD2 SMAD4 PMC12014465__F2 TGFB1 signaling pathway plays multiple roles in amelogenesis KLK4 AMELX MMP20 AMBN AMTN ENAM PMC7050993__F5 Helicobacter pylori Deregulates T and B Cell Signaling to Trigger Immune Evasion NOD1 FOXP3 MTOR CCL20 PMC8781800__F2 Current Aspects on the Pathophysiology of Bone Metabolic Defects during Progression of Scoliosis in Neurofibromatosis Type 1 NF1 GRB2 MTOR PMC12014465__F1 TGFB classical signaling pathway TGFBR2 SMAD4 SAMD3 TGFBR1 PMC4931992__F7 Model of regulatory loop between Shh, IRS1, YAP, and YB1 SHH IGF2 IRS1 PMC8227424__F1 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer RHD REL PMC8677621__F8 Possible mechanism by which MCPIP1 regulates the EMT process and the Beta-catenin level SNAI2 SFRP4 CXXC4 SNAI1 ZNRF3 KREMEN1 CSNK1A1 CTNNB1 PMC7539814__F6 Schematic diagram for blockade of autophagy in stable MED12-mut UtSM clone MED12 MTOR PMC7019488__F4 Steamed bread and baked bread on the cytokine network (a) and central metabolic pathway metabolic network (b) EGF HEL-S-162eP IFNA2 PMC8606765__F1 T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells CD40 IFNG CD80 APC FOXP3 PMC9213282__F1 Influence of endophytes on rice fitness under environmental stresses MYB ERF SOS2 PMC8606765__F3 T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells CD40 CD37 CD19 CD8A MYD88 PMC8606765__F2 T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells TIRAP TLR9 IRAK1 TLR5 IRF3 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR7 TLR10 PMC6320226__F1 Schematic diagram summarizing the regulatory role of the Id1/IGF2/VEGF/VEGFR pathway in esophageal squamous cell carcinoma (ESCC) progression CXCL5 ID1 IGF2 PMC5086583__F1 Immune effector cells induce tumor cell death through apoptosis and necrotic-like cell lysis RIPK3 FAS MLKL RIPK1 FADD PMC6348814__F2 ALDH1A1 regulation, potential retinoid signaling pathways, and functional effects of ALDH in CSCs HEL-S-53e DLL4 SMAD2 SMAD4 SIRT2 CTNNB1 PMC12115913__F4 The molecular mechanisms involving the interaction between the SARS-CoV-2 S protein and NRP1, DPP4, and CD147 cellular receptors DPP4 NRP1 MMP9 ACE2 PMC12115913__F2 The molecular mechanisms triggered by the interplay between SARS-CoV-2 S protein, ACE2, and integrin B1 receptors TF ADAM17 ACE2 IL1B PMC6628717__F3 ErbB-2 Downstream Targets to Promote PCa Tumorigenicity PTEN GRB2 PMC12115913__F1 SARS-CoV-2 infection pathways, spike protein domains, and main receptors TMPRSS2 ADAM17 AXL TLR4 NRP1 FURIN ACE2 PMC6686160__F8 Diagrammatic sketch of the working hypothesis FOXM1 SMAD2 PMC7589635__F1 Genetic pathomechanisms of FSHD types 1 and 2 DNMT3B SMCHD1 DUX4 PMC9111035__F4 Critical evaluation of risk to reward ratio of quercetin supplementation for COVID‐19 and associated comorbid conditions TG UCP1 ABCA1 PMC8722265__F8 SNHG15 is a negative regulator of inflammation by mediating TRAF2 ubiquitination in stroke-induced immunosuppression IL10 TLR4 IL4 ARG1 TRAF2 PMC8719534__F5 Human Metabolites of Hamaforton™ (Hamamelis virginiana L. Extract) Modulates Fibroblast Extracellular Matrix Components in Response to UV-A Irradiation TNC THBS1 MMP14 LAMA1 SPARC MMP9 ITGB3 ITGAV MMP11 SPP1 CD44 NCAM1 ITGA1 MMP2 ITGB5 LAMA3 PS1TP5BP1 PMC3269678__F2 Signaling pathways leading to transcription factors activation in response to UV-radiation KEAP1 RELA MAF ATF2 EIF2A PMC7260202__F5 Crosstalk between androgen and Wnt/Beta-catenin leads to changes of wool density in FGF5-knockout sheep DKK1 SHH LEF1 CTNNB1 PMC5510573__F2 Overview of the human androgen biosynthesis pathways CYB STS PMC3366852__F5 Proposed mechanistic link between Por deletion and up-regulation of MHC II expression in enterocytes HMGCS1 STAT1 CD74 HMGCR MHC2TA SQLE PMVK MVD IDI1 FDPS MVK PMC11292615__F0 This review seeks to offer a comprehensive look at how salidroside impacts gut microbiota and its potential therapeutic role in treating atherosclerosis NLRP3 TLR4 MTOR NOTCH2 MYD88 PMC3556575__F5 Pathways of relationships identified by feeding gene expression patterns identified in erythroid progenitors to the Ingenuity software MAX KIF15 GATA2 SKIL CDC6 COCH PNRC1 ABCG1 WWTR1 CSNK1E HIPK2 TNFAIP2 MAP2K3 TFDP2 MXI1 ZNF124 CENPF DYRK2 PDGFD PTGER2 TEX2 MYOF HHEX CHAF1A TFDP1 ZMIZ1 VEGFA HEL-S-94n CDC34 ORC2 UROS CHI3L1 CPOX RBL1 ENG MCM7 FLI1 WDFY3 CBFB FABP5 HBD TRAF5 MCM5 ERMN IKZF2 SMURF2 HAGH PMC8076952__F8 Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway BAX TRPM7 PTCH1 SMO GLI3 PMC11529329__F3 RPs and proliferation of HCC RPL8 RPS15A CDK5 RPL34 USF1 RPS27A CCND1 CDK4 PMC11529329__F2 RPs interacting with p53 and MDM2 RPL5 RPL11 TLR4 RPL28 MDM2 RPL23 RPLP2 RPL26 PMC3223033__F6 Schematic illustration of the main metabolic pathways based on the proteins identified in the citrus pulp chromoplasts F2 F10 F9 PMC11529329__F4 RPs and metastasis of HCC RPS16 RPS15A RPS6 USP1 RPLP1 FGFR3 MMP9 RPL23 FGF18 CTNNB1 PMC8401288__F1 Single LC-MS/MS Analysis to Quantify CoA Biosynthetic Intermediates and Short-Chain Acyl CoAs HEL-S-5 PPCS PPCDC COASY PMC6759579__F5 Functional overview of the embryonic complement system CD59 FH HEL-S-62p C1S C1R CR2 CD46 C1QBP CD55 CR1 HEL-S-99n C2 CLU C4B_2 PMC9405713__F9 HPV16E7 Affibody as a Novel Potential Therapeutic Agent for Treating Cervical Cancer Is Likely Internalized through Dynamin and Caveolin-1 Dependent Endocytosis CCND1 CDK4 PMC3336771__F1 Endogenous polyamines potentiate macrophage polarization TLR4 ARG1 PMC10670368__F2 SHP2 is critical in regulating RAS/ERK, PI3K/Akt, and JAK/STAT signaling pathways in cancer cells CSK GRB2 MTOR SRC KRAS PMC7139883__F12 Sphingosine kinase 1/S1P signaling contributes to pulmonary fibrosis by activating Hippo/YAP pathway and mtROS SPNS2 SPHK1 YAP1 PMC9356176__F12 The cystathionine Beta-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome ACLY FAS HEL-S-162eP CS PSPH PMC4748291__F5 Paediatric obstructive sleep apnoea syndrome (OSAS) is associated with tonsil colonisation by Streptococcus pyogenes TLR4 MYD88 PMC5569910__F1 The aryl hydrocarbon receptor (AHR) signaling pathway (A) is best known for the induction of xenobiotic metabolizing genes via activation by environmental toxicants AIP AHR PMC6343613__F1 Mechanism of IL-22, IL-22receptor as well as IL-22BP and signaling pathway STAT3 STAT1 JAK1 TYK2 PMC3222852__F1 GSK3 plays pivotal roles in the establishment and maintenance of neuronal polarization RHEB KIF13B TSC2 TSC1 APC PTEN MTOR PMC434255__F13 Current model for IL-7R regulation of survival and proliferation BAX JAK3 BCL2 IL7 JAK1 PMC5575761__F2 Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway BATF GRAP LAT PTEN GRB2 MTOR PMC3222852__F2 GSK3 is a key regulator of axon growth and branching DCX APC GC PTEN PMC2676714__F4 Pathways analysis on the set of genes contained in the SNP component MAPK1 APOE HEL-S-32 TNF ABCB1 MAPK3 PMC5209629__F8 Inflammatory players implicated in lipopolysaccharide- (LPS-) induced M1 polarization of N9 microglial cells and of exosome upregulated microRNAs HMGB1 NLRP3 CX3CR1 TLR4 ARG1 IL1B PMC8125037__F2 PI3K/mTOR Pathway Is Targeted by Rare Germline Variants in Patients with Both Melanoma and Renal Cell Carcinoma STAT3 MC1R NFRKB BAP1 INO80 PTEN HIF1A MTOR SETD2 GNAS TSC2 TSC1 PBRM1 PMC5454924__F1 Schematic presentation of ROS scavenging pathway in chloroplasts PRX PC PMC6200938__F6 Rag-independent Gln stimulation of mTORC1 via PLD-derived PA RHEB SLC3A2 RALA ARF1 PC SLC7A5 PMC5292650__F1 Human myeloid cells identified in the bone marrow, blood, and tissue of cancer patients CD33 CD14 CD163 CD68 PMC3087899__F6 NFKB pathway activation via death receptor signaling TRADD TRAF1 TNF TRAF2 FADD PMC11892029__F3 RNA methylation, DNA methylation, and demethylation in PH KLF4 DNMT3B BMPR2 KLF2 MYADM PTEN YTHDF1 CYP1A1 YTHDC1 FOXM1 MAGED1 ALKBH5 WTAP YTHDF2 METTL3 ELK3 IGF2BP2 PMC3997115__F1 Caspase activation by the extrinsic (Fas-mediated) apoptosis pathway (left) vs FAS NLRP3 FADD PMC8073493__F2 Non-Coding RNAs in the Neuroprotective Effects of Glutathione PI3 BDNF PMC11892029__F2 BMPR2 and CAV‐1 in PAH BMPR2 GMPR2 NFYA DKFZp686P11128 PAH ARHA IL15RA NOTCH3 CCNB1 RAC1 CTNNB1 PMC8007978__F2 Metabolism of macrophages is beneficial to host defense or pathogen survival of during Mtb infection ASS1 F2 HK2 PDC ARG1 PMC2843003__F3 Epicardial-Myocardial Signaling Directing Coronary Vasculogenesis FGFR1 SHH SMO WNT9B GATA4 CTNNB1 PMC5033243__F2 Emerging role of mTOR in the response to cancer therapeutics AXL EGFR APC KIT PTEN ERBB3 RHEB TSC2 TSC1 INSR NF1 TBC1D7 ERBB2 PMC6913967__F3 Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation FAS LAT PTEN FOS LCK PMC11515775__F2 Caffeine metabolism pathway and metabolites POR NAT2 CYP1A2 CYP2A6 AHR ABCG2 PMC4822253__F1 BMP pathway SMAD1 DKFZp781O1323 ID1 ID3 TGFBR1 PMC6813227__F6 Signaling pathways RPTOR EIF4EBP1 SMAD2 SMAD4 IGF1R MTOR SIRT2 TGFBR1 RHEB TSC2 TSC1 IGF1 PDPK1 RPS6KB1 SIRT1 PMC5260886__F8 The serglycin–CD44 signaling pathway in NPC CD44 MYC CCND1 CTNNB1 PMC5522110__F3 Subset of microRNAs defining the side population of a human malignant mesothelioma cell line NRG2 CRK EGF HBEGF JUN BAD CBL TGFA BTC MTOR SHE NRG4 PMC7842751__F9 Cocaine-Dependent Acquisition of Locomotor Sensitization and Conditioned Place Preference Requires D1 Dopaminergic Signaling through a Cyclic AMP, NCS-Rapgef2, ERK, and Egr-1/Zif268 Pathway RAPGEF2 EGR1 PMC3565104__F4 Proposed model for progesterone and retinoid action in endometrium and endometriosis CRABP2 HSD17B2 CYP26A1 PMC11515775__F4 Genetic variants and their effects on caffeine dependence POR CYP1A2 ALDH2 CYP2A6 HECTD4 DRD2 MLXIPL AHR ABCG2 BDNF PMC3652335__F2 Lin28: Primal Regulator of Growth and Metabolism in Stem Cells TCF3 LIN28B HMGA2 LIN28A HMGA1 SOX2 TUT7 TUT4 MYC IGF2 PMC307558__F1 TGFB signaling pathway SMAD4 CDK2 ARHA PMC3814821__F8 Proposed mechanism for the CD8+-cell-mediated suppression of HIV-1 replication CD27 IFNAR2 IFNAR1 CCR7 RNASEL RAC1 PMC4259288__F4 A.Genes with altered expression upon miR-224 stimulation are involved in the cell cycle control MAX NRG1 ATR SIN3A GSK3B SMAD4 CDK2 ATM PMC4090148__F11 Evidence that RASSF1C Stimulation of Lung Cancer Cell Proliferation Depends on IGFBP-5 and PIWIL1 Expression Levels IGFBP5 PIWIL1 ATM CTNNB1 PMC6205166__F4 Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats POR STAT3 JUN MAP3K7IP1 TAB3 PMC7277968__F7 Reverse cholesterol transport pathway and intravascular remodeling of lipoprotein particles during the postprandial phase LPL TG ABCA1 PMC6205166__F9 Cachexia-inducing ability of 85As2 cells LIF IRAK1 TLR5 PMC8955777__F8 Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial–Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer Cells EGF TSC2 JUN TSC1 ERBB2 FOS PMC5709760__F9 TGF‐B1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up‐regulation of IL‐17RB SMAD2 IL17RB SMAD4 PMC4133502__F1 Step forward back to (induced) fetal JUN ATM PMC9340150__F2 Structure, biosynthesis, and biological roles of fetuin-A: A review IFNG NOX4 PMC3298733__F1 New therapies targeting the deregulated pathways to treat TICs in pancreatic cancer CD44 CD24 NOTCH1 PMC8952793__F8 Global MicroRNA Expression Profiling of Buffalo (Bubalus bubalis) Embryos at Different Developmental Stages Produced by Somatic Cell Nuclear Transfer and In-Vitro Fertilization Using RNA Sequencing BAMBI SOST INVS APC CER1 SKP1 RYK ARHA PMC4026697__F3 VKR signaling pathways SHB GRB2 MTOR PMC10311107__F7 Metabolic and transcriptomic analyses elucidate a novel insight into the network for biosynthesis of carbohydrate and secondary metabolites in the stems of a medicinal orchid Dendrobium nobile PAH DDC PMC9479684__F4 When does hepatitis B virus meet long-stranded noncoding RNAs? NR1C1 PCNA HAT1 HOXA13 MTOR CREB1 PMC9479684__F3 When does hepatitis B virus meet long-stranded noncoding RNAs? IFNGR2 IFNGR1 IFNAR2 IRF2 IFNAR1 JAK1 FOS TYK2 IL10RB PMC9479684__F6 When does hepatitis B virus meet long-stranded noncoding RNAs? STAT3 ROCK1 IRF3 APOBEC3B PMC9479684__F5 When does hepatitis B virus meet long-stranded noncoding RNAs? IFNG STAT3 DDX5 MEX3B RELA TLR9 CD160 HDAC11 PMC9031068__F2 Plant-Derived Active Constituents in Cancer Treatment and Their Mechanisms of Action RAF1 GSK3B SRC CTNNB1 PMC9479684__F2 When does hepatitis B virus meet long-stranded noncoding RNAs? CGAS MAVS TLR3 TLR9 TLR8 NOD2 RNASEL TLR7 MYD88 PMC12035894__F2 Carcinogenic mechanisms of estrogen and its metabolites in breast cells MAPK1 EGFR VEGFA PMC3976256__F9 Mycobacterium bovis BCG Triggered MyD88 Induces miR-124 Feedback Negatively Regulates Immune Response in Alveolar Epithelial Cells TLR1 TLR3 TIRAP TLR4 TLR9 TLR7 TRAF6 MYD88 PMC4911278__F5 Alternate metabolic programs define regional variation of relevant biological features in renal cell carcinoma progression RHEB PCK2 TSC2 HEL-S-304 PDK4 TSC1 ALDOB HK3 DLD PTEN PKLR PMC5352068__F14 PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide STAT3 TSC2 ULK1 ATM MTOR EIF2A PMC9040349__F14 Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms RBM38 EHD2 CRMP1 KLHL13 CNKSR1 LINGO1 SH2B2 PROKR1 EPN3 SLC22A17 ANGPT4 PREX1 NNMT MSI1 ELMO1 DGKD INPP4B SYNM CHMP4C GFRA2 GFRA4 PREX2 TRIM72 PMC11033467__F5 Immunomodulatory effects of a probiotic combination treatment to improve the survival of Pacific oyster (Crassostrea gigas) larvae against infection by Vibrio coralliilyticus BIRC7 PSMD10 CAD TNFAIP3 TLR3 RIOK3 TLR4 BIRC2 MYD88 BIRC3 PMC3130144__F6 Molecular mechanism of autophagy with synthesis of cathepsin D TLR3 UVRAG TLR9 ATG14 TLR7 PMC3877165__F2 Schematic view of integration of TCR signal transduction with diverse components of the actin polymerization machinery CDC42 ZAP70 FMNL1 APC ITK VAV1 LCK PMC8623138__F1 Microalgae Xanthophylls: From Biosynthesis Pathway and Production Techniques to Encapsulation Development IPP CS PMC7495093__F7 Pyroptosis of acute kidney injury (AKI) signaling and protective effect of SalB through the nuclear factor erythroid-2 related factor 2 (Nrf2)/NLR family pyrin domain-containing 3 (NLRP3) pathway GSDMD NLRP3 TXNIP PMC5482648__F8 High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin PTBP1 SRC PMC3957180__F1 Scheme depicting interactions of the ET and NO pathway as described in this chapter NOS2 PMC9491642__F1 Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma IL13RA1 JAK3 AHR TYK2 PMC8990771__F3 Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer STAT3 BAX EGF EGFR MTOR PMC8263655__F3 Long noncoding RNAs on tumor immune escape by regulating immune cells differentiation and function VEGFC CCR2 CCL2 PMC5408751__F7 GSK-3B modulation of LKB1-AMPK pathway in autophagy induction ULK1 GSK3B MTOR PMC8990771__F2 Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer STAT3 EGF TGFA EGFR GRB2 MTOR PMC7021580__F3 MED12 and Cancer Drug Resistance CDH2 MED23 MED12 EGF CARM1 EGFR SMAD2 SMAD4 CTNNB1 TGFBR1 PMC11012648__F3 Informed by Cancer Stem Cells of Solid Tumors: Advances in Treatments Targeting Tumor-Promoting Factors and Pathways RNF43 PORCN APC ZNRF3 CTNNB1 PMC11012648__F1 Informed by Cancer Stem Cells of Solid Tumors: Advances in Treatments Targeting Tumor-Promoting Factors and Pathways CD44 EPCAM ALDH2 ALDH1A3 HEL-S-53e ALDH3A1 SOX2 SMO CD55 CXCR4 CTNNB1 PMC3868999__F1 The Hippo pathway signaling cascade results in the phosphorylation and cytoplasmic retention of effector molecules YAP and TAZ LATS1 LATS2 PMC5487850__F1 Biogenesis of microRNA (miRNA), extracellular vesicles (EV) and uptake mechanisms AGO2 NRP1 NPM1 DROSHA PMC9088184__F6 PGK1-coupled HSP90 stabilizes GSK3B expression to regulate the stemness of breast cancer stem cells HEL-S-68p GSK3B CTNNB1 PMC7438542__F1 Co-stimulatory signals that enhance MAIT cell activation STAT3 ICOS IL7R IL23R PMC5380038__F2 DHS and PHS metabolic pathways CERS3 CERS5 UGCG ACER1 SGPL1 CERS1 CERS2 SPHK1 DEGS1 SMPD1 SGPP2 ALDH3A2 SMPD2 CERS6 ASAH2 SMPD4 SPHK2 SGPP1 ACER3 PMC11993959__F2 Signalling pathways that regulate osteoblastogenesis PTCH1 SMO RUNX2 PMC6022935__F1 Streptomyces lividans major secretory route (Sec pathway) HTRA2 HTRA1 PMC2821476__F3 TNFA induced signaling TRADD ITCH TRAF2 FADD PMC3241928__F8 Beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas BRAF PTEN ME1 PIN1 CTNNB1 PMC5380038__F6 PHS metabolic pathway SGPL1 SPHK2 ALDH3A2 PMC5380038__F5 Predicted PHS degradation pathway CERS3 CERS5 UGCG SGPL1 SPHK2 CERS1 SGPP1 CERS2 SGPP2 ALDH3A2 CERS6 PMC6214130__F2 Trimethylamine N-Oxide: A Link among Diet, Gut Microbiota, Gene Regulation of Liver and Intestine Cholesterol Homeostasis and HDL Function ABCG1 NR1C1 CD36 CYP7A1 CYP27A1 ABCA1 PMC9003256__F8 Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop TFAM BAX NHS MFN1 MFN2 PMC8234904__F2 Evidence-Based Chemotherapy for Oral Cancer: Focus on Drug Resistance Related to the Epithelial-Mesenchymal Transition SMAD2 SMAD4 PTEN PMC9030030__F3 Early T-Cell Precursor ALL and Beyond: Immature and Ambiguous Lineage T-ALL Subsets FLT3 BAD MTOR JAK1 PMC8228802__F2 ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development CDC2 BAX TLK1 BRCA1 H2AX RAD9A CDK2 ATM ATF2 PMC8882844__F2 Mitochondrial DNA Depletion Syndrome and Its Associated Cardiac Disease SUCLG1 SUCLG2 PMC8395197__F8 Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis TH PLIN1 CIDEC FABP4 PMC6061130__F3 Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process PINK1 MFN1 MFN2 BNIP3L FUNDC1 BCL2L13 PMC9300530__F3 Metabolomics for the design of new metabolic engineering strategies for improving aerobic succinic acid production in Escherichia coli PGC GAL MAL MN1 CIT PMC5146200__F1 Priming and activation of the NLRP3 inflammasome HMGB1 NLRP3 TLR4 PMC6620619__F4 Platelets involvement in the pathogenesis of AAVs CD40 VWF VCAM1 PMC1796761__F1 Pathway of double-stranded break repair by homologous recombination and the factors involved RAD52 BRCA2 PMC7643020__F3 Crosstalk between autophagy and apoptosis HTRA2 ATG3 TRADD ATG5 DIABLO PMC5226613__F1 Signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases FGF7 TSC2 ATG12 MEI1 BNIP3 MTOR RAC1 FGFR2 PMC5226613__F3 Signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases TLR4 EGFR MTOR TRAF6 MYD88 PMC11202101__F1 Interleukin-17 signaling pathway (Kyoto Encyclopedia of Genes and Genomes (KEGG) ID: Human (Homo sapiens), hsa04657) TH S100A7 TRADD MALL CXCL5 ELL APP CXCL2 TNF CXCL8 CCL20 FADD PMC7533893__F6 NRF2 in regulation of cancer cell metabolism FAS CDO1 UGDH PHGDH MAL ME1 HEL-S-26 CIT PMC10536424__F3 Anti-cancer mechanisms of PDE5 inhibitors NOS2 ARG1 MTOR CCND1 PMC9248441__F2 Understanding the Potential and Risk of Bacterial Siderophores in Cancer BAX FAS DDIT3 LCN2 PMC6752947__F6 Tbx1-Isl1-Met genetic pathway regulates only a subset of CPM-derived muscles MYOG HGF ISL1 TBX1 MYF5 PC CPM PAX7 PMC7533893__F3 Mechanisms involved in the aberrant activation of KEAP1/NRF2 pathway in cancer KEAP1 GSK3B NFE2L2 MICA DPP3 CDK20 PALB2 PMC7533893__F2 Classical KEAP1/NRF2 signaling pathway HMOX1 GPX2 KEAP1 GCLM GCLC SRXN1 ME1 HEL-S-26 PMC10380440__F3 Sexual Dimorphism of Skeletal Muscle in a Mouse Model of Breast Cancer: A Functional and Molecular Analysis IFNG HEL-S-99n TAPBP CANX AFP CUTA TNF PMC10380440__F2 Sexual Dimorphism of Skeletal Muscle in a Mouse Model of Breast Cancer: A Functional and Molecular Analysis TRDN RYR2 HRC CASQ2 PMC9180643__F3 Monoubiquitination in Homeostasis and Cancer HDAC3 PCNA SMAD4 HLTF MDM2 PMC9651583__F4 Integrated text mining and PPI for the combined effects of Hst and VCR on cancer-related signaling pathways CASP9 JUN TGFB1 CASP8 MAK PTEN PTGS2 MTOR VEGFA IL6 TNF INS MAPK8 MYC FOS CASP3 BCL2 PMC7430831__F6 NOD-like receptor signaling pathway and DEGs in NOD-like receptor signaling pathway from KEGG enrichment analysis of R TBK1 NLRX1 MAVS NOD2 IRF3 IRF7 NOD1 TRAF3 PMC6879841__F6 Pathway diagram of glycolysis, pentose phosphate pathway (PPP), and tricarboxylic acid (TCA) cycle highlighting metabolites that differed between control (CON) and intrauterine growth restriction (IUGR) fetal skeletal muscle and plasma HEL-S-133P BCAT1 HEL-S-30 PFKM PMC7698939__F1 Tryptophan metabolism through the kynurenine (yellow), serotonin (blue), and indole (purple) metabolic pathways KYNU KMO AANAT ASMT PMC2718504__F5 Predicted general metabolism and solute transport in T NAPA POR PGP MSC HEL-S-11 PMC12093341__F1 Biosynthetic pathway of CR and strategies used in this study HEL-S-20 ASPA PMC9113786__F1 Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities STAT3 LEPR POMC PMC9442958__F10 ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NFKB pathway by the secretome VEGFC IGF1 TNF PMC4644174__F8 Proposed signaling pathway for TOB-1-mediated progesterone signaling.Notes: TOB-1 was involved in the growth arrest pathway in response to progesterone in MCF-7 cells TOB1 PTEN HEL-S-44 PMC3561798__F6 Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis JAK3 CCL26 HRNR PTPN1 COA1 AHR FLG JAK1 IVL PMC6514922__F1 Hypothetical model for the role of thrombomodulin (TM) in mitogen-activated protein kinases (MAPKs) signaling: Thrombomodulin regulates the activation of MAPKs under various pathophysiological conditions S1PR1 APC FGFR1 PC GPR15 ARHA RAC1 PMC4682714__F2 Provides a schematic and abbreviated overview of the TGFB signaling pathway with indication of aneurismal diseases linked to it SMAD2 SMAD4 PMC3875822__F1 Metabolic model of C4 assimilation, rates of reaction, and net fluxes between and MAL GLA MB PMC4263397__F9 Rgs6 is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra TH RGS6 NONO HEL-S-53e PITX3 FGF10 BDNF PMC8851748__F1 Viral and cellular oncoproteins inhibit the cGAS/STING pathway TBK1 CGAS IRF3 PMC7040094__F1 C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity SAP130 CLEC9A CLEC12A BCL10 IL1B CARD9 PMC12003952__F10 PLEVPs deliver pab-miR396a-5p to mediate down-regulation of the IL-17 signaling pathway STAT3 CXCL5 IL6 CXCL10 PMC9535337__F1 Complement activation in Hidradenitis suppurativa: Covert low-grade inflammation or innocent bystander? C6 FCN1 CD59 FH C7 HEL-S-62p CR2 VTN TNF CR1 IFNG C2 C9 PMC11843235__F6 Working model for ADAM10 in lung cancer CDH2 ADAM10 MMP9 NOTCH1 PMC5400641__F8 MiR-519d impedes cisplatin-resistance in breast cancer stem cells by down-regulating the expression of MCL-1 MCL1 DIABLO PMC3092676__F4 Emerging molecular functions of RASSF8 CSK SRC CTNNB1 PMC3075071__F1 Parsing out the complexity of RAF inhibitor resistance ARAF NRAS PMC5727283__F5 ER stress and the caspase proteolytic system are important regulators of muscle protein homeostasis ATG12 ATF4 EIF2A ATG5 XBP1 PMC6994936__F8 Proposed involvement of FGF9/FGFR2 signalling in human fetal gonad development SOX9 SRY FGF9 WNT4 FGFR2 PMC8502912__F8 LPA1-mediated PKD2 activation promotes LPA-induced tissue factor expression via the p38A and JNK2 MAPK pathways in smooth muscle cells TF LPA PKD1 PMC9265296__F1 New Insights into Hippo/YAP Signaling in Fibrotic Diseases LATS1 TEAD4 PMC10520536__GA1 Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt/Beta-catenin signaling pathway COL1A1 SMAD2 APC GSK3B NET1 CTNNB1 PMC6810856__F10 Rhinovirus -induced SIRT-1 via TLR2 regulates subsequent type I and type III interferon responses in airway epithelial cells STAT1 TLR1 STAT2 IRF9 IRF3 SIRT1 PMC2915755__F1 PCNA-coupled p21 degradation after DNA damage: the exception that confirms the rule? ATR DDB1 PMC8194282__F2 Neuroinflammation in Post-traumatic Epilepsy TLR4 SMAD2 MYD88 PMC8965109__F9 Prognostic Values and Underlying Regulatory Network of Cohesin Subunits in Esophageal Carcinoma STAG2 BRIP1 PIK3CA DKFZp781O1323 APPL1 SOS1 BMPR1A STAG1 SMC3 ZFYVE9 PIK3C2A SMAD4 MED13L LAMC1 CTNNB1 MED12 ACVR1B ARHGEF12 ROCK1 USP1 RB1CC1 MED13 APAF1 TFDP2 TOPBP1 ACVR2B MSH6 RAD50 ROCK2 SP1 NBN PTPN11 SMC1A ZFYVE16 RBL1 RAD21 ANAPC1 CBL GPAM PRKDC CDKN1B CREBBP CDK2 EP300 PMC2970576__F5 Analysis of gene expression in CD44+/CD24− MCF-7/ADR cell population by TaqMan Low-Density Array and Ingenuity Pathway analysis MAX FAS NFKB2 YY1 MYC PELP1 WT1 BCL2L1 CCNE1 NR3A2 CEBPD HSF1 AHR MDM2 SRC CDK4 JUN ID2 TNFSF6 NBN ANXA1 GBP1 MMP9 TNF LBR CEBPA TCF7L2 PRKDC IKBKB ADRB2 TP63 HEL-S-102 EP300 BAK1 PMC4921268__F2 Searching for the Chokehold of NRAS Mutant Melanoma CDC2 CDK6 MTOR CCND1 CDK4 PMC4535548__F12 ERK/MAPK signaling pathway was regulated when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA CRK BAD MOS PXN NFATC1 GRB2 SRC DOCK1 EIF4E PMC7920285__F1 The differences in the localization of the upstream regulators and the core cascade components of the Hippo signaling pathway during murine and bovine embryogenesis AMOT NF2 YAP1 PMC4535548__F11 EIF2 signaling pathway was regulated when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and the pathways were analyzed using IPA ELF2 EIF2A PMC3549669__F6 STING Specifies IRF3 phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway TBK1 DDX41 IFI16 IRF3 PMC2572856__F1 Aging of signal transduction pathways, and pathology APC SMO PTEN NODAL PMC5354754__F1 Novel non-canonical Wnt signature for prostate cancer aggressiveness JUN FYN FZD2 PMC4535548__F14 PI3K/AKT and HSP90 interacted with ERK1/2 when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA RHEB TSC2 BAD TSC1 MCL1 HEL-S-28 PTEN MDM2 MTOR EIF4E PMC5406709__F1 PI3K pathway targeting agents in development for the treatment of prostate cancer TSC2 TSC1 PTEN PMC6631185__F4 Signaling pathway nodes effected by loss of CDK11 in A375 melanoma cells following PanCancer Reactome pathways analysis BRIP1 RFC4 PCNA BRCA2 SFN CCNA2 MYC FANCA FANCC FANCB FANCG CDKN2C WEE1 CCNB1 CCND1 MGMT MSH6 MSH2 POLE2 MDC1 UBE2T DDB2 CCNE2 MCM7 PKMYT1 MAD2L2 BRCA1 CDK2 MCM5 RFC3 MCM2 CDC25B PMC7925099__F1 HIV-1 life cycle, assembly pathway, and assembly plate screen CCR5 CXCR5 PMC4535548__F13 NFKB signaling pathway was regulated via ERK1/2 when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA TBP TRAF2 LCK PMC2844640__F3 Role of Radiation-induced TGF-beta Signaling in Cancer Therapy BAX SMAD4 PMC2904914__F2 Glial cell line-derived neurotrophic factor can signal through a Ras-induced pathway in SSCs GDNF CDK2 ATF1 GRB2 RET PMC3296744__F11 Evolution of JAK-STAT Pathway Components: Mechanisms and Role in Immune System Development PIAS1 JAK1 TYK2 PMC2904914__F1 Glial cell line-derived neurotrophic factor can signal through activation of Src kinases in SSCs GDNF LYN SRC RET PMC2844640__F1 Role of Radiation-induced TGF-beta Signaling in Cancer Therapy SMAD2 SMAD4 TGFBR1 PMC7917554__F3 Pyroptosis NLRP3 CASP5 CASP4 IL1B PMC3546685__F1 Short-patch (SP-) and long-patch base excision repair (LP-BER) sub-pathways NEIL2 FEN1 PCNA NEIL3 NEIL1 PMC7917554__F4 Key features of different forms of regulated cell death GPX4 MIF PARP1 PMC11015457__F9 Compound-target-pathway network STAT3 TH PPARG PIK3CA RAF1 EGFR PTPRC IGF1R TERT MTOR THRA MAPK14 MDM4 PRKCA IL2 KDR MDM2 SRC NR1A2 CDC2 JUN KIT FGF5C PTGS2 MMP9 VEGFA TNF FGF2 PARP1 NR1C1 CASP3 BCL2 MAP2K1 GRB2 SIRT1 PMC2665757__F6 EXT/HSPG pathway involved in both peripheral and central chondrosarcomas EXT2 IHH EXT1 PMC8616344__F7 Identification of Gene Co-Expression Networks Associated with Consensus Molecular Subtype-1 of Colorectal Cancer BAX CASP9 BAD POLK APC SMAD4 GRB2 MYC FOS PMC8569219__F6 Studying the tumor microenvironment and engineering of tumor organoids TF PIK3CA APC BAP1 BRAF SMAD4 PTEN ARHA KRAS CDKN2A NF1 GC GREM1 PMC8474014__F8 Transcriptomic and Metabolomic Analyses Provide Insights Into an Aberrant Tissue of Tea Plant (Camellia sinensis) FH C13orf34 INS PMC7699519__F1 The NRF2 pathway HEL-S-22 GSTM2 KEAP1 TXNIP GCLM PTGR1 SLC7A11 SQSTM1 ME1 GSTM4 HMOX1 GPX2 TXN RBX1 GSTA3 BACH1 HEL-S-128m GSTM1 GSTM3 GCLC MAF SKP1 HEL-S-26 PMC12045473__F3 Chloride channel regulation in human diseases CIC CFTR E2F7 MTOR IRS1 PMC10474666__F4 FBXW7 in breast cancer: mechanism of action and therapeutic potential FBXW7 RELA WEE1 MTOR TNF PMC3702632__F7 TLR4 and chemokine receptor crosstalk ADRBK1 TLR4 CCR2 PMC7195637__F5 Regulation of mTOR on Th17 cell differentiation STAT3 RORC HIF1A SOCS3 MTOR DEPTOR GFI1 PMC7195637__F7 Regulation of mTOR on Th9 cell differentiation FOXO1 HIF1A IRF4 DEPTOR PMC7195637__F6 Regulation of mTOR on Treg cell differentiation FOXO1 FOXP3 DEPTOR PMC8217358__F1 Gene- and RNAi-Activated Scaffolds for Bone Tissue Engineering: Current Progress and Future Directions SMAD1 MAP3K7IP1 DKFZp781O1323 MOG DLX5 RUNX2 PMC8408623__F2 Medical gas plasma-stimulated wound healing: Evidence and mechanisms RBX1 NONO KEAP1 NQO1 HEL-75 PMC7195637__F1 mTOR signaling pathway and its functions TSC2 TSC1 TFEB PC DEPTOR PMC3260518__F1 Invisible hand: regulation of RHO GTPases by RHOGDIs CDC42 SMURF1 ICMT RHO RCE1 PMC3066060__F2 Simplified schematic representation of the apoptosis pathway in mammals and Drosophila BAX FAS DIABLO FADD PMC7277693__F6 Upregulated genes (red boxes) related to ER-stress and leading to apoptosis and protein degradation OS9 EIF2S1 HEL-S-125m EIF2AK1 DDIT3 BCL2 DNAJB11 ATF4 EIF2A XBP1 TRAF2 ERO1B PMC7277693__F5 Schematic view of genes downregulated (green) and upregulated (red) in the biosynthesis and degradation pathway of cholesterol HMGCS1 HMGCR MSMO1 DHCR24 CH25H DHCR7 IDI1 FDFT1 MVK PMC10571764__F1 Therapeutic mechanisms involving elotuzumab and Anti-SLAMF3 in multiple myeloma (MM) TF SLAMF7 CSK GRB2 PMC6049001__F4 In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway MAVS IRF3 IRF7 PMC8672419__F4 FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease TEC BTK SHE PMC8718643__F3 Research Progress on the Mechanism Between Polycystic Ovary Syndrome and Abnormal Endometrium TSC2 GSK3B TBC1D4 PMC6029133__F6 Cancer-related pathway-pathway relationships RB1 CXCR3 FOXM1 ATR SMAD2 IL4 ATF2 IL8RB PLK1 CXCR4 PMC3702532__F8 RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation CANT1 HEL-S-19 NME2 LYZG PMC3702532__F7 RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation SHC1 PIK3R2 GSK3B PTPRF PRKCZ FLOT2 MAPK9 MAPK3 HEL-S-42 PDPK1 PRKAR1A TRIB3 EXOC7 PYGB TRIP10 FOS HRAS PCK2 RHEB CRK ACACB TSC2 TSC1 MAP3K1 FOXO1 SOS2 CALM1 GRB2 BAD RPS6KB2 IGFBP1 IGFBP2 MTOR INS SH2B2 IGF2R HEL-S-80p INSR RPTOR RPS6 JUN FASN PTPN1 ARAF PDE3B GYS1 IKBKB FBP1 LIPE PTPRE INPPL1 MAP2K2 PMC3977809__F2 EGAN analysis showing all the differentially expressed enriched pathway genes CEP290 CCL27 IPO11 XPO4 ALG11 SGMS1 SMC3 KERA EPO FANCM CEP70 FANCE SMC6 POMC SMC2 USP47 SKA2 RFT1 PRTN3 COL2A1 SST CXCL11 CNTFR PHLDA3 CRLF1 GPD2 ZNF443 OFD1 CENPA VCAM1 LMAN1 LACRT FOXE1 MSLN GAS TERT CEP192 PTPN13 CSF3 BLM TEAD4 CCKBR SEMG1 CBLC BCAN TPSAB1 MFAP1 RPP14 KRT37 WRN KRT14 GABRB3 SFTPD SDC1 FGF2 GDF6 TBCE ALG10 FGFR3 IGSF21 PMC5337695__F2 EGR1 regulations and functions in the central nervous system in the context of synaptic plasticity EGR1 STX6 NAB1 SNAP29 CHRNA7 GAD1 ARC GRIN1 SNAP91 PMC4886063__F7 P2-dependent activation of the IRK/PI3K/Akt pathway IGF1 GSK3B PMC3974825__F1 Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer ATR RAD51 ATM PMC7532256__F2 Monoclonal Antibody-Based Treatments for Neuromyelitis Optica Spectrum Disorders: From Bench to Bedside AQP4 CD19 IL6 VEGFA PMC3940258__F5 Paramyxovirus inhibition of IFN signaling pathways STAT1 STAT2 JAK1 TYK2 PMC1716201__F1 Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737 BAX BAD MCL1 BCL2 BMF HRK BIK PMC8669959__F7 Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review BAX TLR9 PTEN VEGFA PMC7694131__F1 Canonical and non-canonical Wnt signaling pathways APC ROR2 GSK3B LRP5 LRP6 ARHA RUNX2 CTNNB1 PMC9160188__F3 Nonapoptotic Programmed Cell Death — Ferroptosis, Necroptosis, and Pyroptosis — in Pancreatic Ductal Adenocarcinoma Treatment GSDMD NLRP3 PMC7373899__F2 Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction SOCS1 IRF2 USP18 SOCS3 PMC8214274__F2 Histone dynamics during DNA replication stress ATR SETX ATRIP RAD51 BRCA2 RIF1 BLM BMI1 RNF2 AQR FANCD2 MCM7 MRE11A DNA2 POLK MCM3 MCM5 MCM6 MCM2 POLN PMC5686050__F1 Interleukin-4 (IL-4) and interleukin-13 (IL-13) receptor complexes PI3 IL13RA1 JAK3 IL13RA2 PMC7596939__F3 MiRNA regulation in signaling processes in obesity, liver and uterine cancers HSP90AB1 SYK JUN BAD ARRB2 GNB2 NFKB2 AKT3 GNG12 LAMB1 FLNA ARAF ITGB1 MAP3K1 PHLPP1 FLT4 CCND2 IFNAR2 PPP2R1B NFATC3 PMC7407311__F7 CXCL14 regulates hESC self-renewal and cell cycle through IGF-1R signaling pathway CDC2 CDK6 SOX2 IGF1R CXCL14 PMC4358129__F11 MiR-199a-5p in smooth muscle differentiation and hypertrophy KLF4 ACTA2 MYOCD CCND1 AXIN2 ID3 PMC7660801__F5 Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement C6 CD59 MBL2 MASP2 HEL-S-62p C9 CS C4A C4B_2 CR1 PMC3343154__F3 Mammalian unfolded protein response (UPR) pathways ATF4 EIF2A XBP1 TRAF2 PMC8469536__F2 From the Evasion of Degradation to Ubiquitin-Dependent Protein Stabilization RNF4 EIF2A CTNNB1 PMC7037239__F1 IL-15 signaling pathways STAT3 JAK3 GRB2 MTOR JAK1 GAB2 PMC4722981__F1 The mechanism of TRPC5 in mediating chemoresistance TRPC5 NFATC3 CTNNB1 PMC4627418__F5 Cytokine receptor interaction network for GBM survival EGF LTA CSF1 LEP LTBR TNFRSF10B EGFR CCR2 EPO TNFRSF10A PPBP CCL21 EPOR IL2 GHR CSF1R CCR1 IL1B TNFRSF11A CSF2 TNFRSF14 IL12A IL13 TNFSF13 LEPR NGFR IL17A IL1A TNF KITLG LTB PRL IL8RB CXCR4 PMC12069117__F21 TREM2 signalling pathways TREM2 SYK CBL LCP2 LAT SOS2 ADAM10 VAV1 GRB2 SRC LAT2 PMC3164671__F5 Genome-Wide Identification of Bcl11b Gene Targets Reveals Role in Brain-Derived Neurotrophic Factor Signaling ATF3 NGF MAPK10 GRB2 BDNF PMC10451232__F4 Transcriptomic changes in p53-associated apoptotic signaling in burn-wound-healing pathway BAX CASP9 JUN HGF CASP8 PMAIP1 TNF IGF1 NFKB1 HAL CASP3 BCL2 BOK CCL4 MDM2 BAK1 APAF1 PMC8684614__F4 Epigenetic modification and BRAF gene mutation in thyroid carcinoma BRAF PTEN CCND1 PMC2593440__F3 Network of differentially expressed genes in the cell cycle control pathway in sorted R1/R2 Eklf−/− E13.5 fetal liver cells ID2 ETV3 E2F2 PPP1CC DHFR RBL2 PPP1R2 E2F7 GABPB1 MAD2L1 PARP1 CCNH COL2A1 RBL1 CAMKK2 CDK6 NDN TOB2 RYBP APP IGFBP7 PARP2 PFAS CDK4 PMC10299161__F4 Oxidative stress promotes the activation of programmed cell death initiated by intrinsic apoptotic signaling in the mitochondria or extrinsic apoptotic signaling by death receptor pathways in CRC cells BAX BAD PMC6165336__F11 AAP-H and the PI3K/AKT/mTOR signaling pathway BAX BAD MTOR PMC5290952__F10 Proposed mechanism whereby RET/PTC3 regulates IDO1 expression in thyroid cancer cells STAT1 IDO1 IRF1 SRC RET PMC7937358__F3 Immuno-pathogenicity of MERS-CoV DPP4 IRF3 ATF2 PMC6951458__F1 Mnk 1/2 signaling SPRY2 EIF4E PMC9523788__F2 Innate and adaptive immune evasion by dengue virus STAT1 IRF9 IFNAR1 JAK1 TYK2 PMC12073561__F5 Small RNAs are involved in the regulation of plant female gametophyte development AGO4 ARF6 ARF3 PIN1 PMC12224056__F3 Schematic representations of the effects of iron chelation on CRC pathogenesis and progression ATR ROCK1 APC ATM MDM2 CTNNB1 PMC5478005__F1 Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 TEF CTNNB1 PMC12224056__F4 TRAIL‐mediated apoptosis pathway BAX FADD PMC6060673__F1 Immunomodulatory approaches for the treatment and prevention of neonatal sepsis TH TLR4 CD14 IL6 CXCL8 IL1B PMC4106090__F1 N-glycosylation pathway GCS1 MANEA MNT GANAB PMC4143615__F2 Top-ranked enriched canonical pathway identified using IPA, the T-cell receptor signaling pathway ZAP70 TEC CBL CRAT FYN SHB LAT CSK ITK GRB2 LCK PMC4106090__F3 GPI anchorage pathway PIGO PIGF PIGH PIGN PIGW PIGL PIGM ERI1 PMC2972271__F5 The metabolite NAD+ oscillates in a circadian manner NAMPT SIRT1 PMC4222698__F2 Clinical utility of pharmacogenomics in the management of hepatitis C STAT1 MAVS STAT2 SI SOCS3 PMC4222698__F1 Clinical utility of pharmacogenomics in the management of hepatitis C RIGI MAVS IFNL4 STAT2 KY IFNAR2 IRF9 IRF3 IRF7 SOCS3 JAK1 TYK2 PMC2860309__F1 EDA signaling LTB DKK4 MADCAM1 DKK1 RELA SHH EDARADD TRAF6 FURIN EDAR LEF1 TNLG7C PMC6768854__F7 MiR-708 expression gradient is reduced during the transformation from normal prostate epithelial cells through adenocarcinoma cells to NEPC CDC2 FOXO1 SESN3 EZH2 TCF4 CTNNB1 PMC11497390__F7 Rosmarinic acid promotes cartilage regeneration through Sox9 induction via NFKB pathway inhibition in mouse osteoarthritis progression ACAN SOX9 COX2 MMP3 COL2A1 IL1B PMC5264327__F8 Working model representing the proposed signaling pathways induced by vitamin D signaling in regulating skeletal muscle mass NR1i1 RPS6 STAT3 EBP FOXO3A BNIP3 IL6 IL6R PMC3477504__F3 Cytokinesis Mechanics and Mechanosensing KIF12 INCENP IQGAP1 PMC3579404__F1 Conserved Wnt pathway branches and components CDC42 TCF3 HIPK2 APC ROR2 LRP5 LRP6 RYK RHO LEF1 PMC8026309__F6 The mechanism through which CTRE inhibits MGO-induced tubular cell inflammation and oxidative stress by upregulating the Nrf2-antioxidant enzyme pathway and downregulating the PKCB/NOX4 signaling IL16 NQO1 GCLC GLO1 TNF NOX4 PMC7946919__F8 Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas FRS2 GRB2 FGFR2 PMC10039784__F1 Deficient radiation transcription response in COVID-19 patients RFWD2 C6 BAX CASP9 ATR FAS SIAH1 CASP8 AIFM2 PERP PTEN MYC TSC2 SIVA1 CASP3 CDK2 BCL2 ATM PIGS MDM2 PMC3252833__F3 Sensitisation of type 2 cancer cells towards DR-induced killing by synthetic IAP antagonists CASP3 PMC6051204__F1 Folate‐mediated one‐carbon metabolism, links to methylation reactions and nucleotide synthesis (by Cheng TY et al MTHFD2 MTHFD1 TCN2 DHFR SHMT1 MTRR HEL-S-61p GGH SLC19A1 MTR HEL-S-51e PMC3252833__F1 Fas-induced apoptotic signalling pathway BAX CASP9 FAS CASP3 BCL2 PMC6854237__F3 Microbiota-triggered EMT via E-cadherin/Beta-catenin APC GSK3B CCND1 CTNNB1 PMC3900498__F1 Yin and Yang of PI3K vs PTEN in the regulation of beta cell proliferation RHEB TSC2 TSC1 PTEN MTOR PMC5449449__F2 Integration of metabolic and fatty acids (FAs) metabolizing enzymes pathway in mitochondrial dysregulation, fibrotic hypertrophy, and chronic inflammation LOX FOXO1 IRS1 PMC7248192__F2 Hyperglycemia-induced oxidative stress impairs nitric oxide signaling NLRP3 TXNIP IL16 HEL-S-162eP VCAM1 PMC11008464__F1 New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis NAGS ASS1 ASL GLS MAL HEL-S-5 SIRT5 OTC ARG1 ME1 NAT8L CIT PMC5098220__F3 Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks CD40 STAT3 SYK RAF1 SOS1 SHC1 PILRB PXN PIK3CD JAK3 IL3RA PIK3R2 PIK3R1 PRKCZ SOCS2 IRAK1 SOCS3 TRAF6 IRAK4 MYD88 MAP3K2 TEC STAT1 FYN HEL-S-1 MAPK1 NMI CRKL IL7R VAV1 IL1A IRS1 HEL114 PPP6C CRK IL1RN RXRA MAP3K7 FES BCL2 GRB2 CXCR4 BAD IL2RG IL2RA PPP2CA TERT MTOR MAP3K14 IKBKG IL1R2 IL1R1 RARA PLCG1 SHB CSF2RB CHUK IL2 CEBPB IL1B JUN ETS2 YES1 PTPN11 NCOA1 BCL2L11 PTPN6 RAC1 NR3C1 CBL NFKB1 RPS6KB1 RELA NFKBIA SIRPA EP300 JAK1 NLK LYN GAB2 YWHAZ PMC5555610__F2 RAS Proteins and Their Regulators in Human Disease PIK3CA RGL3 RAF1 MAPK13 SOS1 RASGRP3 RPS6KA2 PIK3CD RPS6KA1 BRAF KSR2 RASA2 RASAL1 NRAS DUSP16 RASAL3 MAPK1 RASGRP4 JUN ETS2 KSR1 DAB2IP KRAS FOS ARAF SYNGAP1 CBL RASA3 RAPGEF2 RAPGEF1 RRAS RPS6KA3 MAP2K1 RRAS2 PMC5098220__F2 Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks NR2C2 PRMT1 RAN ERCC2 PXN EGFR PIK3R2 PIK3R1 SPDEF RANBP9 ATF2 RAC3 CCNH RB1 CDK7 CCNE1 SRY PAK6 MDM2 SRC CREB1 ETV5 CCND3 JUN SP1 NR3C1 PIAS2 HDAC1 RUNX1 BRCA1 FOXO1 PIAS1 CREBBP IL6ST GTF2H2 CDC25B PMC4084718__F4 Contextualizing Sharpin within the NFKB pathway by comparative analysis of mutant transcriptomes SHARPIN IL16 RBCK1 NFKBIA IL18 IL1A TRAF6 TNF MYD88 PMC11396780__F9 Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism of Protopanaxadiol Triphenylphosphate Derivative in Non-Small-Cell Lung Cancer SLC16A3 SIRT3 PGAM1 YARS HEL-S-133P EGFR MARS1 FGFR3 MTOR SIRT6 PMC5355171__F2 Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer? CDC42 BAX BAD GSK3B PTEN KRAS PMC5098220__F1 Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks GRIA2 PIK3R2 PIK3R1 PPP2CA RANBP9 NCK2 SH2B2 TRAF6 CRTC1 FYN FRS3 GRIP1 CREB1 DOK5 NCK1 FRS2 DOCK3 NGFR NTRK2 PTPN11 GABRB3 RAC1 SORT1 TIAM1 SIRPA GRB2 BDNF PMC2528242__F1 Peroxisome proliferator-activated receptorG and ligands: pathways and functions STAT3 JUN SP1 CD36 TNF FOS PMC3998676__F1 ADVANCING AGE IS ASSOCIATED WITH GENE EXPRESSION CHANGES RESEMBLING mTOR INHIBITION: EVIDENCE FROM TWO HUMAN POPULATIONS RHEB STAT3 TSC2 TSC1 SGK1 ULK1 IRF7 PTEN IRS1 PMC5648159__F6 Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells LATS1 FFAR3 FFAR2 YAP1 PMC7589994__F1 Role of the best-characterized HDACs in liver fibrosis BAMBI HDAC1 TGFB1 TLR4 SMAD2 SMAD4 HDAC9 EZH2 HDAC2 SIRT1 PMC4376617__F7 The role of T cells in the anabolic activity of iPTH in trabecular bone WNT10B CD40 LRP5 LRP6 PTH PMC9647849__F4 Mass spectrometry‐based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways SPN BAX GAL ABO MCU SNCA PMC5338674__F7 Model for Pol E function in plant DDR ATR RAD51 BRCA1 WEE1 ATM PARP2 PMC5129950__F1 miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1 MAX BMI1 NRG1 ATR SIN3A PAK1IP1 SMAD4 CDK2 ATM MDM2 SUV39H1 PMC7028499__F7 21-BENZYLIDENE DIGOXIN DECREASES PROLIFERATION BY INHIBITING THE EGFR/ERK SIGNALING PATHWAY AND INDUCES APOPTOSIS IN HELA CELLS BAX CASP9 EGFR CASP3 PMC6071020__F5 Neurotrophin signaling pathway and genes involved in the significant gene links (marked in red box) BAX CRK BAD FRS2 SI RHO SHE BDNF TRAF6 RAC1 PMC6349306__F1 Epicatechin modulates stress-resistance in C. elegans via insulin/IGF-1 signaling pathway SGK1 PMC8741964__F1 Impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites HEL-S-90n KYNU KMO PMC4111852__F3 PI3K pathway in different breast cancer subtypes TLR4 PTEN PMC5428929__F6 Genome-wide transcriptome profiling of radish (Raphanus sativus L.) in response to vernalization PRR9 ELF3 CAT56 PMC7373816__F2 Metabolic regulation of the Hippo-YAP signaling network LATS1 OGT LATS2 CGAS AMOT JCAD IRF3 ARHA MTOR IGF2 PMC7373816__F1 Hippo-YAP signaling network LATS1 HEL-S-31 CDK7 AMOT NLK SRC PMC8655512__F2 Progranulin as a Potential Therapeutic Target in Immune-Mediated Diseases STAT3 COMP FOXO4 JUNB TLR9 PRTN3 PMC3485747__F1 Glutamine:fructose-6-phosphate amidotransferase 1 (GFPT1)–mediated MTOR signaling pathway affected by glucose and fructose in porcine trophectoderm cells RPS6 TSC2 EIF4EBP1 GFPT1 MTOR PMC7429631__F2 Profilin can be phosphorylated at S137 by Rho associated kinase (ROCK) downstream of vascular endothelial growth factor (VEGF) signalling, reducing actin polymerisation rates RHO SRC PMC7429631__F1 Profilin interactions in the membrane EGF PTEN MTOR PMC7300907__F10 Increasing host cellular receptor—angiotensin‐converting enzyme 2 expression by coronavirus may facilitate 2019‐nCoV (or SARS‐CoV‐2) infection STAT3 TBK1 MAVS STAT2 IRF9 IRF3 STAT1 TLR3 IFNAR2 IFNAR1 JAK1 TYK2 ACE2 PMC8323830__F2 Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy RAD52 RAD51 DNA2 BRCA1 BRCA2 PMC3187694__F1 Simplified model of autophagy ATG12 MTOR PMC4707157__F1 Mechanisms by which mitochondrial DNA activates innate immunity TLR9 IRF3 IL1B PMC3291562__F4 Function-Based Discovery of Significant Transcriptional Temporal Patterns in Insulin Stimulated Muscle Cells SOCS1 PIK3CA RAF1 SOS1 PIK3R2 ARF6 PIK3R1 GSK3B MAP3K11 MAPK9 SOCS3 MAPK8 MAPK3 MAPK14 MAP3K8 GRB10 CAP1 MAPK1 FLOT1 IRS1 RHEB TSC2 PRKCI TSC1 MAP3K1 PRKCQ SOS2 MAPK7 MAP3K7 MAP2K5 MAPK10 MAP3K5 SNAP23 PPP1R3A HEL-S-61 RRAD MAPK11 VAMP2 MAPK13 GYS2 RPS6KB2 SHC2 MAP3K14 XBP1 PRKCH CBLC MAP2K3 MAP4K3 RAC1 CBL INPP4A IKBKB LIPE INPPL1 SNAP25 GRB14 MAP3K6 TBC1D4 STXBP3 EHD1 EHD2 STXBP1 KIF3A RAB4A MAP3K10 SHC1 MAP3K13 MAP3K12 SLC2A4 ARF1 PIK3CD PIK3C2G PIK3C2A PRKCZ PTPRF MAP4K2 MINK1 SGK2 PRKAA1 MAPK6 MAPK4 MAP3K2 HEL-S-42 PIK3R4 MAP2K6 PDPK1 PRKCA MAPK12 TRIB3 FOS EIF4E HRAS CRK GRB2 HEL-S-31 PIK3R3 PTEN INS ENPP1 MAP2K4 INSR MYO1C PFKM SHC3 JUN EGR1 EIF4EBP1 MAP4K1 PTPN1 PTPN11 IRS4 GSK3A GYS1 RPS6KB1 PRKAA2 MAP2K1 MAP2K2 PFKL PMC8323830__F1 Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy ATR ATRIP RAD51 BRCA1 BRCA2 ATM PMC7115894__F4 Effect of elevated Na+ on cancer progression and the tumour microenvironment GLS SIK3 IL4 RAC1 PMC8277109__F2 Nutrient signaling pathways altered by methionine restriction (MR) HEL-S-182mP IGF1 FGF21 ELF2 UCP1 ATF4 PMC9331286__F1 T Helper 22 Cells in Dermatological Disorders STAT3 STAT1 CCR6 AHR CCR4 MTOR JAK1 CCR10 TYK2 IL1B PMC5683188__F1 Localization of key lipids and enzymes, designated by the genes encoding them, in different cellular compartments in S CDS1 PC PSD2 PMC3983226__F1 Predicting Kinase Activity in Angiotensin Receptor Phosphoproteomes Based on Sequence-Motifs and Interactions BAD PMC9035589__F9 Microbial Utilization of Next-Generation Feedstocks for the Biomanufacturing of Value-Added Chemicals and Food Ingredients FAS NADK PDC CS PMC9105930__F1 Insight into the Role of the PI3K/Akt Pathway in Ischemic Injury and Post-Infarct Left Ventricular Remodeling in Normal and Diabetic Heart BAX MLKL GPX4 GSK3B PTEN IL1B PMC3632731__F2 Network 2 (metabolic disease, renal and urologic disease, and molecular transport) generated by pathway analysis of the hot list LTBP2 ADCYAP1R1 MCAM HEL-S-269 PTPRN CD99 SPP1 RYR3 FPR1 LAMB2 APP HEL-S-87p GRIA4 TEF PMC3632731__F1 Network 1 (antigen presentation, cell-mediated immune response, and humoral immune response) generated by pathway analysis of the hot list C6 ATR CLSTN3 ENO2 PLG AFM C4A COL18A1 C2 A2M APP MB C4B_2 LPP VASN PMC8669501__F1 SNAIL1: Linking Tumor Metastasis to Immune Evasion SUFU SMAD2 APC SHH SMAD4 MTOR CTNNB1 PMC11840414__F1 Steroidal glycoalkaloids biosynthetic pathway in potato (Solanum tuberosum) and tomato (Solanum lycopersicum) GCA PGA3 PMC10986082__F2 Multiple mechanisms of environmental stress regulating CSC transcription A The immune cells in TME activate the STAT, Wnt, AKT and Notch pathway of CSC by mainly releasing cytokines (IL-6) and inducing contact TF CD44 POSTN MTOR CTNNB1 PMC8836862__F10 Blood Bacteria-Free DNA in Septic Mice Enhances LPS-Induced Inflammation in Mice through Macrophage Response TLR4 TLR9 IRF3 TRAF6 MYD88 PMC10986082__F1 Targeting TFs in CSC from multiple perspectives A Directly blocking the combination of TFs and DNA: mainly through epigenetic mechanisms TF CD44 SMO CTNNB1 PMC6304621__F3 General representation of the signaling pathways involved in CBD anticancer mediated effects TRPV2 TRPV1 GPR55 PMC6215866__F3 Transforming growth factor‐beta pathway and the Wnt/Beta‐catenin pathway SMAD2 LRP5 LRP6 CTNNB1 PMC6215866__F2 Positive feedback loop between the Rspo/Lgr5 pathway and the Wnt/B‐catenin pathway RNF43 LRP5 LRP6 GPR49 CTNNB1 PMC6215866__F1 Mouse breast carcinogenesis induced by the activation of the canonical Wnt pathway GSK3B LRP5 LRP6 MYC CTNNB1 PMC5854685__F8 Pathway from hippocampal molecular defects to AD neurotoxicity HEL-S-128m CPLX2 PRDX3 PMC6328535__F6 Dacarbazine and PLX4032 cross-resistance emerges via distinct MAPK-dependent and -independent pathway activation PDGFRA BRAF NRAS MTOR PMC5215656__F6 Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways NGF EGR1 CDK5 CAD FOSB PAK1 CTNNB1 PMC11085123__F1 Biosynthetic pathway of terpenoids (A), alkaloids (B), and phenylpropanoids (C) in plants IPP MVP MVK PMC7598160__F3 Glycolysis and oxidative phosphorylation in the retina VLDLR HEL-S-5 CPT2 FFAR1 PMC6471220__F3 Transcriptional effects in zebrafish liver after feeding with 25% of maize substitution FAS BCKDK APOE SLC38A4 CTH PAH ACACA SLC16A10 INS MAT1A GDA PMC3628745__F2 New signaling network for melanoma CHP2 TNC CXCL13 EGFR APC BRAF PTPRF KIT KITLG FGFR2 SHC4 NRAS FGFR3 WNT4 SRC PMC8230717__F3 Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study BAD EPO BOK HEL-S-11 PMC9386448__F2 Phytochemical and pharmacological profile of taraxasterol BAX GSDMD NLRP3 COX2 TLR4 IL6 MTOR IL1B MYD88 PMC8230717__F2 Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study CDK2 CYC1 NLK INS PMC6062380__F4 Gender specific differences in the liver proteome of rats exposed to short term and low-concentration hexabromocyclododecane (HBCD) †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6tx00166a DDT HEL-S-22 GATA2 EHD3 FABP1 HEL-S-269 GDA ALB HEL-S-20 RBP1 PAH FDPS TTPA KNG1 SGTA HEL-S-299 SERPINA1 PON2 HEL-S-47e HEL-S-162eP PON1 HEL-S-69p EEF2 HEL-S-61p HP FAHD2A PMC2927527__F2 “Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress ATF4 EIF2A XBP1 PMC3416961__F1 Simplified diagram depicting Ras signaling and crosstalk with PI3 kinase- Akt pathway in leukemia FLT3 BCR MTOR PMC3274818__F1 Activation of an RTK induces dimerization and downstream phosphorylation of non-receptor tyrosine kinases CDC42 NF1 EGFR PTEN RHO GAB2 PMC9274112__F3 HMGB1/TLR4 and IL-1B/IL-1R1 Signaling Pathways in Epilepsy TLR4 TRAF6 MYD88 PMC9274112__F2 HMGB1/TLR4 and IL-1B/IL-1R1 Signaling Pathways in Epilepsy IL1R1 GSDMD TRAF6 MYD88 PMC9274112__F1 HMGB1/TLR4 and IL-1B/IL-1R1 Signaling Pathways in Epilepsy TLR4 SMAD2 IRF3 TRAF6 MYD88 PMC3394505__F9 Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas APC PTCH1 PMC8919059__F6 Genomic And Tumor Microenvironment Differences Between Cell Cycle Progression Pathway Altered/Non-Altered Patients With Lung Adenocarcinoma LEP TUBA3E FAM9C TDRD12 IL1A IGF2 PHOX2B ALOX15B MAPK4 CDKN2A EREG INHA HLA-G TRIM71 CTCFL PMC8919059__F5 Genomic And Tumor Microenvironment Differences Between Cell Cycle Progression Pathway Altered/Non-Altered Patients With Lung Adenocarcinoma SPP2 FOXD1 NTS SFTPA1 LEP CPB2 TAGLN3 SPRR2E ELAVL3 SPRR2F SPRR2G PLA2G2A ALB CCKBR CASP14 CHRNB2 GC NPY PAH SLC5A2 CRP KRT5 GAL AMBP SERPINA10 SYNPR HRG NTRK2 SFTPD FOXG1 NEFH SPRR2D SCGB1A1 SFTPB ALDOB ChAT SPRR2A SH3GL2 SNAP25 CALCA STMN2 PMC4350422__F1 Immunologic manifestations of autophagy TBK1 MAVS IL16 ULK1 TLR9 IRF3 TLR7 PMC2947220__F8 Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer FAS CDK2 PMC9622808__F6 Schematic model CYP7B1 CYP27A1 PMC545795__F3 Largest connected subgraph resulting from combined query on four pathways involved in carbohydrate metabolism: glycolysis/gluconeogenesis (red); pyruvate metabolism (yellow); TCA cycle (green); and the glyoxylate cycle (pink) ENO2 HEL-S-68p PGM2 GAD1 PIR ACD CIT PMC6829426__F13 A potato plant’s response to weak light and exogenous Ca2+ C2 CIT PMC4276148__F1 Regulation of miRNAs in NHL PXDN PTEN MYC CCND1 SIRT1 PMC4896088__F1 Nodes of therapeutic blockade in the PI3K and other signaling pathways that synergize with BET inhibition INPP4B PTEN MDM2 MYC IRS1 PMC3033967__F8 Structural Characterization of the Polar Lipids of Clostridium novyi NT. Further Evidence for a Novel Anaerobic Biosynthetic Pathway to Plasmalogens PGP PSD C1S PMC2983087__F2 Mechanisms of double-strand break repair in somatic mammalian cells BARD1 RAD51 BRCA1 BRCA2 PALB2 PMC3134378__F3 Regulation of HIF-1A by the PI3K pathway TSC2 TSC1 PML PTEN MTOR CA9 KRAS PMC5673087__F3 Diagrammatic representation of hypothesized molecular mechanism of LH signaling dysfunction in PCOS women modified from RAB5B HMGA2 CYP17A1 INSR NF1 CYP11A1 KIAA1608 GATA6 TOX3 FSHR YAP1 PMC7450969__F4 Ribosomal/TRP53 pathway pattern mediated by Salmonella infection TNFRSF8 RB1 RPL39 FAS SDCBP PCNA F2 PTEN RPL9 PSEN1 CDK4 PMC11672923__F8 Signaling pathways involved in adipocyte metabolic disorders caused by melatonin decline with aging and HFD in eWAT NLRP3 GPX3 MMP9 CEBPB PMC8773898__F2 MicroRNAs and Long Non-Coding RNAs in Sarcopenia MYOG IGFBP5 MYF5 MEF2C IRS1 PMC3134378__F2 Regulation of HIF-1A by the MAPK pathway BRAF CA9 KRAS RAC1 PMC5699945__F5 Proteomic Analysis of the Glutathione-Deficient LEGSKO Mouse Lens Reveals Activation of EMT Signaling, Loss of Lens Specific Markers, and Changes in Stress Response Proteins HEL-S-22 ACOT7 HMOX1 GSTM2 GSTM1 GLS PHGDH HEL-S-67p ALDH3A1 PMC4500461__F2 Genome-Wide Identification of Differentially Expressed Genes Associated with the High Yielding of Oleoresin in Secondary Xylem of Masson Pine (Pinus massoniana Lamb) by Transcriptomic Analysis IPP PMVK MVD MVK PMC7429854__F8 Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy AQP4 NRG1 HBEGF EGFR PMC8920547__F4 Clinical Characteristics of Patients With IgG4-Related Disease Complicated by Hypocomplementemia C6 SLAMF7 C7 C5AR2 C2 C9 PMC3376391__F2 Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease KEAP1 PRX PMC6536719__F5 EGL-9 inhibits the HIF-1 target NHR-57 from reducing RAS/MAPK signaling through a DELTA/NOTCH-induced negative feedback loop EGF EGFR EGLN3 PMC11011857__F3 Genetic Signature of Human Pancreatic Cancer and Personalized Targeting EGF EGFR MTOR KRAS PMC6120701__F3 Interleukin (IL)-2 signaling pathway TF IL2RB RAF1 JAK3 IL2RA GRB2 JAK1 PMC10031116__F6 Extracellular matrix stiffness—The central cue for skin fibrosis CDC42 TRAF4 SMAD2 SMAD6 TGFBR3 SMAD4 ARHA TRAF6 PMC3723562__F7 Polyethyleneimine Mediated DNA Transfection in Schistosome Parasites and Regulation of the WNT Signaling Pathway by a Dominant-Negative SmMef2 WNT1 HDAC9 PMC8776636__F1 Ovarian Biomechanics: From Health to Disease FOXO3A GC KIT PTEN CTGF PMC10031116__F5 Extracellular matrix stiffness—The central cue for skin fibrosis PARVA SPSB1 HEL-S-28 TGFBR3 MTOR RHO TGFBR1 TGFBR2 LATS1 TRAF4 LATS2 GRB2 SRC UNK PMC5883129__F1 Ubiquitin cascade TRIM62 TRAF6 PELI1 PMC4927085__F8 Long noncoding RNA LINP1 regulates double strand DNA break repair in triple negative breast cancer EGFR ATM PMC11794838__F9 HU protecting against DKD in this study BAX IL6 VCAM1 PMC4418220__F9 Crystalline silica-induced leukotrieneB4-dependent inflammation promotes lung tumor growth LTB CXCL2 CS PMC8802208__F1 DSB repair pathway choice PNKP RAD52 RAD51 BRCA1 WRN BRCA2 PARP1 XRCC3 PMC8602044__F4 Plasma triacylglycerols are biomarkers of Beta-cell function in mice and humans COX7B AGPAT5 NDUFB5 NDUFV3 NDUFA9 NDUFB9 AGPAT4 NDUFV2 NDUFS5 HSD17B11 COX7C DEGS2 NDUFA13 NDUFAB1 NDUFA10 HSD17B12 ST3GAL1 COXFA4 UQCRB NDUFB4 PIP4P2 NDUFS6 NDUFA3 UQCRC2 UQCRH NDUFB3 ST3GAL3 NR1i1 HSD3B2 CERK ATP5PB NEU3 TTC7B PLA2G12A GPD1 COX7A2 ABHD6 PITPNC1 HEL-S-49 COX6B1 NDUFA5 PMC5332470__F1 T cell differentiation and the emergence of CMV-induced T cell phenotypes CD27 CCR7 PMC4509649__F3 Trade-Off between Growth and Carbohydrate Accumulation in Nutrient-Limited Arthrospira sp. PCC 8005 Studied by Integrating Transcriptomic and Proteomic Approaches RPE APC MAP2 MAEL PMC11913853__F12 Differentially expressed genes implicated as top candidates for mediating the effect of selective breeding on behavior are often regulators of bioenergetic function UCP2 LIPT2 SPG7 OGDH LSR WDR93 MCU PMC5226821__F13 m6A-Driver: Identifying Context-Specific mRNA m6A Methylation-Driven Gene Interaction Networks RAF1 SHC1 MYC LAMB1 TRAF4 BCL2L1 CDK6 SNRPE MDM2 HNRNPK LSM4 MAPK1 WBP11 CRKL VEGFA PUF60 HRAS CRK PRPF31 CDKN1A CHERP CDKN1B MAX SF3B1 TGFB1 EGFR IGF1R SNRPC TCERG1 DDX42 TGFBR2 RARA ARNT2 U2AF2 TPM3 CTBP1 CCND1 JUP BAX HNRPA3 SNRPA PRPF4 PTPN11 ARAF CBL NFKB1 RELA CREBBP TRAF2 FADD PMC7823498__F1 Biological regulatory network (BRN) of IP3R with tumor suppressor and onco-proteins BAX BAD PML PTEN MTOR PMC9404922__F1 Expression of Key Factors of the Hippo Signaling Pathway in Yak (Bos grunniens) Mammary Gland LATS1 LATS2 PMC6664075__F6 Hypothetical scenarios for the role of NGF after systemic oxidative stress NGF KEAP1 GCLM PMC7435111__F1 Scheme of the heme biosynthesis pathway and membrane transporters PPT1 ABCG2 FECH UROD UROS PMC10304648__F1 Detection of influenza A virus infection by pattern recognition receptors (PRRs) and NLRP3 inflammasome RIGI MAVS NLRP3 TLR3 IRF3 IRF7 TLR7 HP PMC5820294__F1 Signaling pathways involved in the progression of extramammary Paget’s disease CDH2 CDK6 CCR4 MTOR CXCR4 CDK4 CCL17 PMC7530063__F8 Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro-myelinating genes MBP PRX UGT8 PMC6805690__F6 Noise-induced bistability and resolution of fate dichotomies PTEN MDM2 HES1 SIRT1 NOTCH1 CTNNB1 PMC11708511__F7 Inhibition of triple-negative breast cancer growth via delphinidin-mediated suppression of the JAK2/STAT3/PD-L1 pathway STAT3 CD69 PMC8868551__F8A Folic Acid Homeostasis and Its Pathways Related to Hepatic Oxidation in Adolescent Rats Exposed to Binge Drinking CYP2E1 DHFR NOX4 PMC3152951__F1 Interaction between HCV and Nuclear Receptor-mediated Pathways FAS NR1C1 CD36 CYP7A1 PMC6805690__F4 Notch-induced autophagy and translational noise as destabilizers of cellular memory GSK3B PTEN MCM6 MTOR MCM2 MYC PMC6805690__F1 Notch pathway amplifies intrinsic noise by interactions that improve the efficiency of global protein synthesis GSK3B PTEN HIF1A MDM2 MYC HES1 CTNNB1 PMC7241336__F1 De Novo and Salvage Biosynthesis of Pyrimidine Nucleotides for Host and Viral RNA SynthesisGSK983 is a DHODH inhibitor CAD CDA UCK2 CMPK1 UMPS DHODH PMC6912418__F2 Mechanism and signaling pathways involved in mitochondrial adaptation in heart following exercise CITED4 IGF1 PMC7073175__F10 The proposed mechanism underlying the TCEE-mediated anti-inflammatory effect in ECs and atherosclerosis APOE VCAM1 PMC4496299__F4 Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation DDT ARID1A UCP1 CD133 LGI1 TNS1 PCSK9 KCNB1 EIF2S1 MYL1 PHLPP1 TNNI3 RBM38 NEU3 ACADS APOE RPE65 RBP4 IRS1 NEDD8 NR1C1 ANGPTL4 MAP1A ACAT2 ACADL BMP5 CP PMC5994774__F5 Both mTOR and eIF4E phosphorylation are needed for polysomal recruitment of terminal oligopyrimidine messenger RNAs (TOP mRNA) MLST8 TTI1 PTEN GRB2 MTOR DEPTOR EIF4E PMC9313364__F7 Chemokine CCL4 Stimulates Angiopoietin-2 Expression and Angiogenesis via the MEK/ERK/STAT3 Pathway in Oral Squamous Cell Carcinoma STAT3 CCL4 ANGPT2 PMC5994774__F2 Scheme of PI3K/Akt/mTOR pathway depicting both complexes mTOR protein takes part in, mTORC1 and mTORC2 RHEB TSC2 TSC1 TTI1 PTEN MTOR DEPTOR EIF4E PMC5883129__F2 Activation of NEMO and IKB by multiple signaling pathways TRIM25 RELA TRAF3 TRAF6 IRAK4 PMC3753467__F1 IP3 instigates the activation and amplification of NFATc1 PLCG2 NFATC1 TRAF6 GAB2 PMC9654807__F1 Prognostic and Therapeutic Potential of DNA Damage Repair Pathway Alterations and Homologous Recombination Deficiency in Lung Cancer ATR RAD51 BRCA1 BRCA2 ATM PALB2 PARP1 XPC PMC3886798__F3 Overview of the treatments in the context of previous results obtained with a test system based on the fluorescent reporter protein H 6-GFP-BD-CVIL in transgenic tobacco BY-2 cells HRAS NRAS FOS PMC5552450__F6 Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis PHGDH PSAT1 PSPH PMC7416122__F2 Network of actual biochemical pathways constructed for S CDS1 GPT2 MAL ENO1 ERG MAEL POT1 CIT PMC2953497__F10 Tumor Necrosis FactorA Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells SMAD1 EGR1 DKFZp781O1323 NFKB2 RPS14 FBXW11 FOXS1 POM121 PCOLCE ATP2A2 FBXL20 HMGCS1 RPS27 RPS26 SMURF1 BRCA1 PAP SP4 NFKBIA JAG2 KLK10 ASB2 NOTCH1 UBB PMC9521401__F2 Dietary organosulfur compounds: Emerging players in the regulation of bone homeostasis by plant-derived molecules DCSTAMP SMAD1 FAS GCLM NQO1 GCLC CTSK MSC OSCAR SFN NFATC1 RUNX2 PMC4352427__F1 TRAIL-receptor mediated signalling pathways BAX TRADD BCL2 BOK TRAF2 PMC3843161__F3 Biomarker-guided translation of brain imaging into disease pathway models STAT3 GAP43 RAF1 SHC1 SDC4 PTPRC ADD2 MYO1F GNAZ PSENEN GRB10 FYN TP53AIP1 BNIP2 MBP MAPKBP1 KDR PARP2 CRADD RPAP3 SMC4 MMP7 DCC TNFRSF14 USO1 TNFSF6 HEL103 STK24 NCF4 PRTN3 FOS SATB1 PICALM TIAM1 BCAP31 NEDD4 PLCB1 PSEN2 DFFA ADRB2 CASP10 EDAR LMNA CDC42 HEL113 NFKB2 AKT3 PPP2CA CYP4B1 CNP RUNX2 RPL30 BFAR MAP2K4 IL18 MUC1 RIPK1 APP NOD1 PLD2 TFAP2A ARHA RAC1 CD34 RADIL CHD3 ARHGDIB TFCP2 IFT57 PRKDC NFKBIA RRAS LYN GRB14 PS1TP5BP1 PMC10815595__F1 HBV-HCC pathways of top 10 downregulated miRNAs VDAC3 JUN FAS MYC KRAS TGFBR1 MAPK3 RB1 CDKN1A NFKB1 CHUK CDK2 BCL2 GRB2 SRC PMC10815595__F2 HBV-HCC pathways of top 10 upregulated miRNA DDB1 CASP3 SRC PMC5479307__F4 There are similarities and significant differences in light and dopamine mediated phase regulation of the retinal clock in Xenopus leavis driving melatonin release and that in mice driving PER2∷luc expression OPN5 DDR1 PER2 OPN4 PMC7904891__F1 Susceptibility and protective factors of the lectin pathway of complement and complement receptors, for HBV infection per se and HBV infection/leprosy MASP1 FCN3 HEL-S-62p C4A C4B_2 CR1 PMC7188667__F4 Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression UGT2B15 UGT2B28 UGT2B17 PMC5686097__F2 Cellular metabolic pathways driving mononuclear phagocyte inflammatory vs ACLY HEL-S-62p C2 HK2 RET IL1B PMC7744503__F7 Mycoplasma pneumoniae lipids license TLR‐4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response NLRP3 TLR4 IL1B PMC8226122__F4 Thromboplasminflammation in COVID-19 Coagulopathy: Three Viewpoints for Diagnostic and Therapeutic Strategies MASP2 HEL-S-62p C1R PLG PMC4643722__F3 Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases APP FADD PMC6843432__F4 Coordinated contribution of ROS and BMPs to vascular diseases ALPL COX2 BMP2 CASP3 XDH TRAF6 RUNX2 NOX4 PMC6278198__F5 Schematic summary of the possible mechanism for GLCCI1 in glucocorticoids pathway GC GCGR GLCCI1 IL1B PMC6284329__F3 Decorin in cancer, based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database (http://www.genome.jp/kegg‐bin/show_pathway?hsa05205) EIF4B TIMP3 TLR4 EGFR CASP3 MMP2 MMP9 MTOR VEGFA TNF CD63 PMC6843432__F1 BMP signaling pathways RELA MTOR TRAF6 PMC3753831__F2 ERK1/2-mediated regulation of the BCL2 protein family BAD FOXO3A MCL1 BRAF BCL2 BMF PMC3753831__F1 ERK1/2-mediated regulation of the G1-S phase transition JUN CCND2 BRAF MYC CCND1 PMC5977009__F1 Toll-like receptor signaling pathway TBK1 MAP3K7IP1 TLR3 TLR4 TLR8 IRF3 IRAK2 IRF7 TLR7 TRAF6 IRAK4 MYD88 PMC6335330__F1 Epigenetic regulation at the RUNX3 AS-associated locus IL7R IRF4 RUNX3 PMC3368734__F7 Functional interaction network analysis of genes with enriched expression (EE) and differential splicing (DS) in the placenta GATA2 CSF2 CITED2 ADM GADD45G SP1 NFATC2 JUNB FOS GATA3 SP3 EP300 CA9 PMC9538505__F11 TRPV1 channel in spermatozoa is a molecular target for ROS-mediated sperm dysfunction and differentially expressed in both natural and ART pregnancy failure CALU HEL-S-269 APOE SFN ANXA1 B2M MIF HEL-S-30 CDC34 VCP MICOS10 MPO ALB TFAM SDHB ATP1B3 DDB1 CLU HEL-S-162eP GDF15 SRPK1 ENO1 KRT13 PMC6678087__F3 Representation of the two serrated pathways BRAF HP KRAS MGMT PMC7163052__F1 Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer NGF EGR1 GDNF KRAS PMC8456215__F1 Emerging Targets in Type 2 Diabetes and Diabetic Complications TSC2 TSC1 GSK3B PMC6287696__F1 The mechanism by which Rel/NFKB-dependent STING expression activates antiviral autophagy to restrict ZIKV infection in fly brain REL ATG5 PMC5676072__F1 Sirtuin roles in Hedgehog, Wnt/B‐catenin, and Notch stem cell signaling pathways DACT1 BCOR APC GSK3B SIRT2 BCL6 SIRT1 CTNNB1 SIRT6 PMC5891173__F3 Aldo‐Keto reductase 1C2 (AKR1C2) expression in prostate cancer cell lines HSD3B2 CYP17A1 AKR1C2 PMC8257776__F1 Molecular pathways of apoptosis and necroptosis BAX TRADD MLKL CYLD FADD PMC4143352__F7 Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease STAT3 ASS1 C3AR1 CCL3 PTPRC CTSS CTSZ HMOX1 TYROBP OSMR HEL-S-171mP CYBA TM7SF2 RGS14 ID2 INPP5D NRARP B2M HEL70 IRF8 CTSA TPP1 GFAP C1QC HLA-B ITGB5 LAPTM5 PDLIM2 CD300C CNP ITGAX ABCA1 PLEK TREM2 CD83 CX3CR1 5HT1A C4B_2 JUN CXCL13 KCND2 USF1 LIN7B FXYD7 POU3F1 PLXDC2 ARL2BP HEL-S-130P C1QA GNS ARF3 NCKAP1L CD68 PMC11951496__F1 Double role of IL-6 in the pathogenesis of atherosclerosis NLRP3 TLR4 MYD88 PMC4264188__F2 BMP signaling pathway SMAD1 DKFZp781O1323 ID1 PMC4143352__F5 Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease C6 C7 HEL-S-62p C3AR1 C1S C9 CR2 C4A ITGAX C4B_2 CR1 PMC6876322__F4 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis of the target genes of CTD-2357A8.3 in HNSCC tissues STAT3 WIPF3 MLLT1 SLC3A1 TXNIP GSK3B ZNF708 ZNF417 MDM2 SRP19 PIM2 MNT ZNF329 HEL70 AGAP1 PTK2B TFAP2B WNT7B PRCP NONO BTG2 SCML2 SASH3 TFRC PSD4 TEAD2 LCOR ACVR1B TNFRSF13C ANP32E PEAK1 TPM3 MLL2 FOXC1 LDLR WNT7A HEL-S-108 FMNL3 ACVRL1 EPHB4 LRP8 ANKRD23 CCL11 E2F2 NGFR NEK4 TERF1 XRCC3 ZFP30 SOCS7 SLC39A1 HEL-S-47e ZNF394 SAMD4B SESN3 REL PMC1761701__F10 Proposed model of lacritin mitogenic signaling pathway lacritin signaling suggested by data outlined in the text LPA LACRT STIM1 SDC1 MTOR PMC8335813__F6 HHLA2 deficiency inhibits non‐small cell lung cancer progression and THP‐1 macrophage M2 polarization CDH2 CDK6 EGFR HHLA2 MMP2 CDK2 MMP9 CD163 CDK4 PMC3787301__F4 The physiological and metabolic landscape of Melainabacteria MALL AIP CIT PMC7736543__F2 Reciprocal signaling between the capsule and cortex coordinately regulates SHH and Wnt pathway activation PTCH1 SHH ZNRF3 SMO WNT4 RSPO3 CTNNB1 PMC7736543__F1 Adrenal cortex employs multiple cell populations with stem cell function to support cellular renewal WT1 CYP11B2 SHH PMC2736203__F2 Impact of a mixed microbial challenge on cell cycle control in HIGK OXT ATR PCNA ATM PMC3759014__F1 The main constituents of the Sonic Hedgehog (SHH) pathway include the SHH ligand and the transmembrane proteins PTCH1 and SMO PTCH1 SHH SMO PMC4832107__F2 Genome-wide gene expression analysis for S49 (Neo) and S49 (OS 4–25) cells BAX CAD PMC7115196__F6 Pathway network associated with PCOS LEP F2R RBP4 IL12B SPP1 PMC11039994__F8 Levels of p53 govern the hierarchy of DNA damage tolerance pathway usage POLL REV1 PCNA PCLO HLTF POLI ZRANB3 PRIMPOL POLN PMC8621344__F2 Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration REST PAX7 PMC8141177__F1 LINC00261: a burgeoning long noncoding RNA related to cancer APC CTNNB1 PMC3237867__F1 Metabolic pathways, transport, and receptors of S1P SPNS2 RHO PMC11997273__F2 The vagus afferent nerve conveying gastric-derived ghrelin signals NTS GHSR ARC PMC2832309__F2 WWOX gene and gene product: tumor suppression through specific protein interactions JUN HGF ERBB4 APC WWOX RUNX2 PMC9598866__F5 Metabolite Profiling of Paraquat Tolerant Arabidopsis thaliana Radical-induced Cell Death1 (rcd1)—A Mediator of Antioxidant Defence Mechanisms GAL IPP GLS PMC4182081__F3 Regulation of TCF7 and HSP90AA1 by hsa-miR-185-5p in a prostate cancer pathway BCL2 PTEN MDM2 PMC4182081__F2 Regulation of YWHAG, YWHAB, and PCNA by hsa-miR-185-5p in a cell cycle pathway MALL SMAD2 ORC1L PMC2530034__F1 Transcriptional regulation and the pathway of RNA polymerase II transcription POLL CDK7 POLI CDK9 PMC2491640__F5 Regulatory network of important genes involved in EBV-dependent NPC HEL107 STAT3 SP1 EGFR JUNB KMO JAK3 EMP3 IMPDH2 MMP9 FOS DEK PTMAP7 CDX2 CDKN1A HOXA9 CD9 MEIS1 CDK2 MAP3K5 GADD45A PSPH PMC2600469__F4 Genes regulated by SHP in PPAR signaling pathway LPL CD36 SCD CP PMC4182081__F4 Regulation of TCF7 by hsa-miR-20b-5p and hsa-miR-17-5p in a thyroid cancer pathway TPR BRAF MYC RET CTNNB1 PMC4349157__F1 Sphingolipid metabolic network HEL-S-22 LPA GCLM GCLC SMPD1 OPLAH GPX1 PMC3889683__F3 Schematic presentation of potential signaling network of HER2-NFKB-PI3 K-Akt-STAT3 RB1 STAT3 PTPN13 MAP9 PMC11280308__F3 Mechanisms of action of the A CDC2 CDC42 CDH2 STAT3 BAX CD80 TRADD STAT2 IL13 SMAD2 SMAD4 MTOR IRF4 TNF STAT1 CDK2 APAF1 CREB1 CDK4 FADD PMC6128084__F6 Cellular metabolism for heme synthesis during early and late erythropoiesis SLC25A38 SLC25A22 ALAS1 ALAS2 CP PMC6522942__F1 Cell surface and endosomal signaling pathway of TLRs JUN TLR9 TLR5 IRF3 IRF7 TRAF3 TRAF6 FOS MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC6678403__F3 Negative role of AMPK in angiogenesis SMAD1 DKFZp781O1323 SMAD4 MTOR HES1 PMC6522942__F3 Polyphenols modulating upstream (TLR activation) and downstream (different kinase and transcription factors) pathway of surface and endogenous TLR to reduce or demolish pro-inflammatory cytokines and type I interferon generation TIRAP TRAF6 IRAK4 MYD88 PMC6522942__F2 TLRs-signaling in microglial cells in different neurodegenerative disease progression TLR1 MGAT3 TLR4 TLR9 TLR5 TLR7 IL1B MYD88 PMC6678403__F1 Regulation of sprouting angiogenesis DLL4 HES1 PMC4898593__F5 Signal transduction from G-protein-coupled receptors and integrins CDC42 ARHH SYK PLCG2 ARHA SRC DOCK2 PMC1386711__F4 MAPK signaling pathway mapping CDC42 FUS SELL FAR1 OPA1 PMC6721652__F1 Canonical WNT pathway in on and off states APC LRP6 CTNNB1 PMC9240865__F3 Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease LPA MBOAT7 RET PMC6721652__F4 Drugs developed against canonical WNT pathway components SOST PORCN TNKS DKK1 APC LRP6 CTNNB1 PMC9240865__F2 Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease LPA MBOAT7 PC PMC6182840__F1 The sorting mechanism of exosomal miRNA MiRNA genes are transcribed into primary miRNAs (pri-miRNA) by Pol-II AGO2 DROSHA EXPH5 PMC6721652__F3 Canonical WNT pathway components associated with disease APC LRP6 CTNNB1 PMC8393842__F1 Adding Some “Splice” to Stress Eating: Autophagy, ESCRT and Alternative Splicing Orchestrate the Cellular Stress Response ATG10 ULK1 CHMP4B TSG101 MTOR ATG5 CHMP2B PMC4217539__F6 Human pre-BCR-induced signal transduction depicted from the current study ZAP70 PAX5 RAG1 PMC8983055__F3 Proteomic and Phosphoproteomic Changes of MAPK-Related Inflammatory Response in an Animal Model of Neuropathic Pain by Differential Target Multiplexed SCS and Low-Rate SCS CRP STAT3 HMGB1 HEL113 HEL-S-62p SORL1 APOE ORM1 CFH ILF3 CS CHI3L1 AHSG CNTFR CNTF NRG1 TLR4 A2M AIFM1 LBP HMGB2 PMC6716664__F3 MicroRNA regulation in colorectal cancer tissue and serum LTBP1 ACVR2A TGFBR3 NODAL ARHA TNF PITX2 TGFBR1 BAMBI IFNG INHBA FST CREBBP PMC6716664__F2 MicroRNA regulation in colorectal cancer tissue and serum KLF2 MAFK CCK BRAF BNIP3 PTEN INS INSR CDK2 ATM NLK MDM2 REL PMC9223523__F3 Mutations of GCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa DEAF1 TUB TRAF6 MYD88 PMC3951797__F6 Postsqualene cholesterol biosynthetic pathway EBP SC5D DHCR24 DHCR7 PMC9223523__F5 Mutations of GCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa TUB ATF2 REL CYLD FADD MYD88 PMC9223523__F4 Mutations of GCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa CAD DPT RYBP TRAF6 REL CYLD FADD PMC3428657__F1 The signaling pathway ofGHRregulated by let-7b IGF1 LEPR SOCS3 GHR IRS1 PMC7643606__F2 Leishmania spp.-induced activation of the NLRP3 inflammasome SYK GSDMD NLRP3 IL1B PMC7643606__F1 NLRP3 inflammasome GSDMD NLRP3 IL1B PMC7827203__F3 Crosstalk of MDSC and Treg CD40 STAT3 CD80 KYNU CCL5 LAG3 PMC4250176__F6 MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells HEL-S-28 PTEN PMC7665128__F2 Calcium homeostasis and signaling in healthy neurons ORAI1 STIM1 MCU PMC6499991__F6 Proposed model of participation of SNHG1 in the regulation of signaling pathways that contribute sorafenib resistance in HCC cells SLC3A2 PTEN MTOR CCND1 PMC7948403__F5 Ferroptosis in Alzheimer's disease VIT GPX4 BACE1 PMC5485509__F2 Histone modifications regulate gene transcription involving renal fibrosis of diabetic kidney disease SMAD2 WDR5 PMC5945880__F1 Interferon-gamma (IFNG) canonical signaling pathway STAT1 IRF1 JAK1 PMC10896652__F1 Relationship between NGF/TrKA signaling pathway and KOA peripheral hyperalgesia PGP NGF TRPV1 PMC2789789__F6 Scheme of the biosynthesis pathways for PC, PE, and PS in human P PSD PC PMC5769535__F1 Neurotransmitters signalling pathways in cancer STAT3 NGF GDNF EGFR MTOR RET PMC10869479__F3 P2X7-mediated signaling pathway NLRP3 APP RAC1 IL1B PMC11646805__F2 Diagram of endothelial cell mutant GAq signaling (p RHEB TSC2 TSC1 PTEN MTOR PMC5746412__F5 PKM2 in carcinogenesis and oncotherapy EGFR MTOR TRIM35 PMC6774422__F2 LRRK2 substrates involved in vesicle trafficking and synaptic transmission RAB43 RAB10 RAB12 RAB24 RAB18 RAB7L1 RAB35 PMC8836911__F1 Theranostic Interpolation of Genomic Instability in Breast Cancer CDC2 ATR RAD51 CDK6 BRCA1 BRCA2 CDK2 ATM PTEN GRB2 MTOR CDK4 PMC6543238__F1 Tumor immunity by radiotherapy and immune checkpoint blockade CGAS APC TREX1 PMC4077896__F1 Autophagic structures in the regulation of MAPK phosphorylation EGF RAF1 PMC8927079__F2 Aryl Hydrocarbon Receptor in the Pathogenesis of Environmentally-Induced Squamous Cell Carcinomas of the Skin EPHX1 AHR PAH CYP1B1 CYP1A1 PMC8927079__F1 Aryl Hydrocarbon Receptor in the Pathogenesis of Environmentally-Induced Squamous Cell Carcinomas of the Skin TF EGFR AHR AHRR CYP1B1 CYP1A1 PMC8102695__F1 Use of the Anticoagulant Heparin and Corticosteroid Dexamethasone as Prominent Treatments for COVID-19 PAF1 TFPI APC ACE2 PMC3527701__F2 Mammalian N-end rule pathway.,,, N-terminal residues are indicated by single-letter abbreviations for amino acids UBR5 UBR1 UBR4 NTAQ1 NTAN1 ATE1 CP PMC6115613__F5 Summary of the signaling pathways involved in cell migration and invasion through p75NTR STAT3 JUN TRIO ARF1 KIDINS220 TCF4 MMP9 ARHA RAC1 CTNNB1 NGF TIAM1 MMP2 SRC BDNF LEF1 TWIST1 PMC3043160__F4 Calcium-mediated mechanisms of cystic expansion RHO CTNNB1 PMC6115613__F4 In some cases, migration and invasion are stimulated through NGF or proNGF upon activation of p75NTR and TrkA NGF JUN KIDINS220 MMP2 TCF4 ARHA MMP9 SRC LEF1 TWIST1 CTNNB1 PMC6115613__F3 p75NTR and TrkB pathways STAT3 JUN TRIO TIAM1 ARF1 KIDINS220 MMP2 ARHA MMP9 BDNF TWIST1 RAC1 PMC8421567__F1 Emerging Role of T-Cell Immunoglobulin Mucin-3 in Breast Cancer: A Promising Target For Immunotherapy STAT3 CXCL13 CTNNB1 PMC4485494__F3 Glycogen Synthase Kinase-3 in Insulin and Wnt Signalling : a Double-edged Sword? APC LRP5 LRP6 CTNNB1 PMC5777890__F7 Reactive Oxygen Species Damage Drives Cardiac and Mitochondrial Dysfunction Following Acute Nano-Titanium Dioxide Inhalation Exposure NDUFB6 NDUFA9 CYCS MTIF2 NDUFA6 UQCRQ NDUFA10 NDUFS3 HADHB SUCLG1 HSPB2-C11orf52 NDUFB4 NDUFA3 SIGLEC9 UBC ACO2 HEL-S-67p DLG4 SNCA UQCRC1 SDHA IVD ACSL1 ITGB1 OGDH NDUFS1 PMC7599585__F3 Distinct mechanisms leading to Nrf2 activation in cancer cells TRIM25 KEAP1 FN3K PMC4074489__F4 p58IPK and UPR-associated inflammatory signaling pathways ATF4 EIF2A TRAF2 PMC7139386__F1 Defects in Galactose Metabolism and Glycoconjugate Biosynthesis in a UDP-Glucose Pyrophosphorylase-Deficient Cell Line Are Reversed by Adding Galactose to the Growth Medium HEL-S-19 GAL UGDH PMC6276109__F1 Breast Cancer Stem Cells: We’ve got them surrounded CXCR3 STAT3 EGFR RELA PTEN SRC CYLD PMC7783806__F8 Pathway signalling network generated from the 1000 most differentially methylated genes PMCH FLT3 PRKD1 PITX1 NFATC2 ZNF652 PLK1 MAPK3 MAPK14 CBFA2T3 MAP3K8 FZD3 SNAI1 CSNK2A2 BCR SRC GHR TRIP11 ROCK2 LRP5 ASXL1 AREG MYOG EFNB1 EPHB3 RXRA MAPK7 MAPK10 BHLHE41 TRADD TP53BP2 TSHR FZD10 TNFRSF1A EGFR PTEN KCNN4 IL11RA THRA PRKCB LTB4R SIRT3 HEL25 RARA NR1B3 MAP2K4 NME2 RARB GPA2 CTBP1 POU1F1 IL11 FOXP3 RXRB DUSP7 DUSP8 EGR1 KRT14 PTPN1 EPHB1 GJB2 NCOA1 PTPRG NCOR2 NFKB1 ERBB2 EP300 CCNK PRKG1 MCHR1 PMC4091760__F2 Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1A signaling node AHR TBP PMC7778818__F5 The HO in the present case SMAD2 BMP2 RUNX2 PMC9138070__F1 Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle KEAP1 DHFR MAF PMC2148057__F8 Proteosomal degradation pathway NEDD4 PSME4 HLA-G HEL-S-283 HLA-A PMC9221178__F5 Microbial-Derived Toll-like Receptor Agonism in Cancer Treatment and Progression TBK1 TLR3 TLR4 IRF3 TRAF3 PMC9221178__F4 Microbial-Derived Toll-like Receptor Agonism in Cancer Treatment and Progression MAP3K7IP1 TIRAP TLR3 TLR4 APC IRAK1 TRAF6 IRAK4 MYD88 PMC2148057__F6 Sugar metabolism pathways in MCF-7 and ZR75-1 cells profiled by GenMAPP PRLR HEL107 PC PMC9221178__F2 Microbial-Derived Toll-like Receptor Agonism in Cancer Treatment and Progression MAP3K7IP1 TIRAP TLR3 TLR4 APC IRAK1 TRAF6 IRAK4 IL1B MYD88 PMC2148057__F5 GenMAPP view of energy production pathway in MCF-7 and ZR75-1 cells NDUFB2 NDUFB5 COX7A1 UCP3 NDUFV3 SURF1 NDUFB9 NDUFV2 CYCS UCP1 NDUFS8 NDUFAB1 COX17 NDUFS4 UCP2 SLC25A4 NDUFS6 NDUFB1 COX3 NDUFA3 NDUFB3 SPIC NDUFC2 SDHA NDUFB10 SDHB SLC25A6 COX11 SDHC PMC7366512__F1 Biomaterial-triggered complement activation drives early thromboinflammatory changes during hemodialysis TF FH C5AR1 HEL-S-62p C2 C1S IL1B PMC2775119__F3 Ciliary functions of cystoproteins: mechanosensation and cell cycle control CDC2 CDK6 CDK5 ID2 PC CDK2 CDK4 PMC9627224__F1 RNASeq profiling of COVID19‐infected patients identified an EIF2AK2 inhibitor as a potent SARS‐CoV‐2 antiviral JUN ELF1 TLR4 ELF2 TLR9 IRF1 TNF FOS ELF3 PMC4039002__F9 Aggregate-Prone R120GCRYAB Triggers Multifaceted Modifications of the Thioredoxin System HDAC3 HEL-S-101 BAG3 INS PMC5224520__F7 Bridging topological and functional information in protein interaction networks by short loops profiling RCC1 RAN CDC14B ECD GADD45G BUB1B STAG1 SMC3 SMAD2 GSK3B ANAPC2 SMAD4 TYMS MYC SKP2 FLNA PTTG2 CCNB3 RRS1 RB1 PSMD3 CDKN2A RALA RBBP4 E2F4 RPA3 SPC24 SMC2 MDM2 ESPL1 MSH2 ANAPC10 WEE2 TFDP1 MYH10 NBN PRIM1 RAD21 ME2 CDC45 MCM3 CDK2 MCM6 MCM2 TGFB1 ERCC2 CDC20 ORC6 CDC6 SFN PSMA2 CCNH PSMD1 TUBA4A CDK7 YWHAQ HEL-S-80p HCFC1 MYH9 TTK ATM VPS4B CCND1 PSMD6 CDK4 DBF4 NUP107 ORC3 ORC2 RPA1 CHD3 RBL1 FZR1 RAB11A MAD2L2 PRKDC SKP1 CREBBP RFC3 DCTN1 PMC5173156__F6 Down-regulation of Krüppel-like factor-4 by microRNA-135a-5p promotes proliferation and metastasis in hepatocellular carcinoma by transforming growth factorB1 NR1i1 CDH2 KLF4 PMC4533315__F4 ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis ERBB3 RNF41 NRG2 MATK NRG1 AKT3 ERBB2 RPS27A UBB PMC3670293__F1 JAK-STAT pathway in hypertrophic stress signaling and genomic stress response STAT3 LIF PMC4533315__F3 ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis PIK3CA BAD RAF1 LAT PIK3R3 PIK3CD PIK3R2 AKT3 SMAD2 GSK3B PIK3R1 BRAF SMAD4 MAPK9 MAPK8 MYC RAC3 MAPK3 TGFBR1 CTNNB1 BIRC5 CCND1 MAPK1 BAX CASP9 MSH6 JUN DCC MSH2 APC ARHA RAC1 FOS TCF7L2 CASP3 BCL2 MAPK10 MAP2K1 LEF1 PMC6528196__F3 Predicted metabolic pathway of lignocellulose-derived inhibitors MOK COCH PMC5963631__F5 Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage response RPS15 EIF2B1 EIF4B RPS23 RPL32 RPS14 EIF2S2 EIF2S3 RPL37 RPS11 RPL3 EIF3G RPS24 EIF3CL EIF3C RPL41 RPS25 RPL9 EIF5B PMC6968989__F2 Genetic pathways effected by mutations in maxillofacial bone tumours GNAS NF1 APC FGFR1 BRAF MDM2 KRAS CTNNB1 PMC5883416__F2 Calcium in cell cycle G1/S transitioning via the MAPK pathway RB1 CCND1 CDK4 PMC2826554__F1 Beta-AR-dependent translation initiation MTOR EIF4E PMC6646053__F1 Antibody mediated complement activation CD59 VTN CD46 CD55 CR1 PMC3670293__F4 JAK-STAT pathway in hypertrophic stress signaling and genomic stress response STAT3 LIF CDK9 TEF PMC6320836__F6 Status of proteins that participate in the autophagy pathway in glioblastoma ULK1 EGFR UVRAG HIF1A SQSTM1 ATG5 CTNNB1 PMC7722191__F1 Action of novel therapies in ET and PV MPL EPO JAK1 PMC3319453__F2 Insulin, IGF-I and IGF-II binding to IR and IGF-IR BAX BAD FAS GSK3B ELF2 PTEN MTOR IRS1 EIF4E TSC2 TSC1 HSF1 MDM2 GRB2 PMC9414313__F2 Exosomes: Small Vesicles with Important Roles in the Development, Metastasis and Treatment of Breast Cancer STAT3 DKK3 NUMB EZH2 NOTCH1 CTNNB1 PMC2931413__F1 Hermaphroditism in Caenorhabditis nematodes.(A) The Caenorhabditis hermaphrodite gonad SDC1 SDC2 SDC3 PMC4831703__F1 The isoprenoid biosynthetic pathway (IBP, ) provides critical substrates for posttranslational modification of proteins that modulate cell signaling and regulatory processes IPP RAP1A FDPS PMC4520528__F2 B cell-derived cytokines direct the ensuing immune response LTA TNF PMC7073546__F4 Synthesis of capsaicinoids adapted from Mazourek et al AMT CS PMC4916380__F3 Central metabolic pathway in C. tyrobutyricum COG5 HPR PTS HBD PMC7290354__F5 PI3K/Akt pathway can be activated in different ways, as for example by G-protein coupled receptors (GPCRs), integrin or cytokine receptors and it represents a mediator between ECM and fibroblasts’ cell cycle TSC2 BAD TSC1 MTOR PMC11674331__F5 PAK1 and PAK2 in angiogenesis PAK1 RAC1 PMC11674331__F4 PAK1 and PAK2 in vascular remodeling BAD PAK1 RAC1 PMC8456215__F8 Emerging Targets in Type 2 Diabetes and Diabetic Complications SEMA4D HIF1A NOTCH3 SRC NOTCH1 PMC9163835__F4 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway BAX HMGB1 TLR4 TFEB BCL2 PMC7456540__F8 Working hypotheses of two opposing mechanisms that concomitantly drive and silence nerve injury-induced latent sensitization TRPA1 TRPV1 NPY PMC9163835__F3 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway RHEB BAX WNT3A BCL2 PTEN PMC3153965__F7 Network representation of altered cellular functions during colonization of the mouse colon by A CD3D HLA-DMB HLA-DOB CD36 SELPLG HLA-DOA CD22 IL4 CD46 HEL70 ATF2 PTPRCAP SPN F2 CD3G CP PMC6562438__F1 Schematic overview of pathways that are involved in desmoplasia in pancreatic cancer, including drugs and their targets CD44 VEGFB VEGFC VEGFD SMO MTOR VEGFA PMC9163835__F2 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway STAT3 TSC2 HMGB1 TSC1 TLR4 TFEB MTOR PMC9163835__F1 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway NLRP3 NQO1 GCLC PTEN MTOR PMC11674331__F6 PAK1 and PAK2 in the regulation of vascular integrity and permeability CDC42 PAK1 PMC6117929__F8 TGFB1 and E2 cause differential regulation of genes involved in extracellular matrix turnover MMP14 TIMP3 TIMP1 RECK TIMP4 THBS2 MMP9 FAP TFPI2 CMA1 DPP4 MMP2 A2M PMC8228183__F17 NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology TGFB1 NOX4 FGF2 PMC12217801__F6 Proposed molecular mechanism by which PBM preserves erectile function in diabetic mice MAX NGF BDNF FGF2 PMC7081179__F1 7Alpha-Hydroxylase and (25R)26-hydroxylase pathways of oxysterol biosynthesis AKR1D1 CYP8B1 HSD3B7 CYP7B1 CYP27A1 AKR1C4 PMC9300166__F1 Mismatch repair and clinical response to immune checkpoint inhibitors in endometrial cancer MSH6 MSH2 PMS2 POLE PMC8228183__F20 NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology NOX5 NOX3 DUOX1 DUOX2 NOX4 PMC3203699__F8 TRAF3-mediated positive and negative regulation of IFN signaling MAVS TANK IRF3 IRF7 TRAF3 PMC4115241__F5 Schematic drawing showed activated HFSCs contributed to SN development SOX9 CTNNB1 CD34 PMC5014091__F1 Wnt/Beta-catenin upregulation in CRC and PDAC APC GSK3B AXIN1 DVL2 SULF2 CTNNB1 PMC6200703__F2 Regulatory effects of lncRNAs and miRNAs on autophagy in malignant tumorigenesis STAT3 HMGB1 ATG3 ATG12 PTBP1 MTOR STX17 PMC8411705__F2 Neutrophils in Glioma and Brain Metastases IFNG HMGB1 TRPM2 TLR9 POLI MMP9 VEGFA CCL2 CXCL8 PMC6635658__F7 Schematic model depicting the possible mechanisms of nobiletin-mediated inhibition of renal cancer cell proliferation STAT3 YY1AP1 SRC PMC9396497__F1 MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury BRD4 SEMA3A NRP1 LINGO1 ARHA PMC7789600__F2 Roles of lipoproteins in the exogenous, endogenous, and reverse cholesterol pathways LPL TG PMC9010872__F1 O-GlcNAcylation and Its Role in Cancer-Associated Inflammation OGA OGT PGM3 GFPT1 PMC3181220__F3 Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma RHEB TSC2 TSC1 PTEN EIF4E PMC4730267__F2 Gene members (green rectangle) in the PPAR signaling pathway that are regulated by maternal high fructose in the male offspring kidney at one day of age (red stars) LPL UCP1 HEL-S-28 PLTP APC2 PMC186370__F1 Spot 42 RNA mediates discoordinate expression of the E. coli galactose operon CRP GAL PMC1766780__F2 Cytokine signalling and the pathogenesis of severe combined immunodeficiency (SCID) IL15 IL-21 IL4 IL2 IL7 JAK1 IL9 PMC4817799__F4 Regulation of neural precursor plasticity within the classical neurogenic zones PGC EGF ASCL1 APC GC SHH PTEN PMC10921668__F8 The early ATL80-dependent response to WDS and its presumed function in retrograde signaling pathways MYB ERF CAMTA1 PMC8228183__F22 NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology STAT3 NR1C1 NOX5 PAK1 IL4 MMP2 NOX4 EIF4E PMC3666312__F1 Current landscape for T-cell targeting in autoimmunity and transplantation APC HEL-S-171mP MTOR PMC8438230__F3 Glioma Stem-Like Cells and Metabolism: Potential for Novel Therapeutic Strategies GLUD1 GLS HEL-S-133P HK2 PC GPT PMC7170819__F2 Angiogenic factors and receptors involved in GBM angiogenesis STAT3 EGFR MTOR PMC8565990__F1 BTK Inhibition in the Treatment of Chronic Lymphocytic Leukemia: A Clinical View CD79B SYK CD79A BTK PLCG2 BLNK CD19 LYN MTOR PMC5203884__F1 p53 suppresses the cell proliferation mediated by the Rb-E2F pathway ATR CDK6 CDK2 ATM MDM2 CDK4 PMC8640807__F2 Recent advances of SIRT1 and implications in chemotherapeutics resistance in cancer PGAM1 ABCC1 SIRT1 PARP1 PMC7517653__F6 SFR changed substrate metabolism in ruminal epithelium CYP24A1 COL1A1 COL1A2 FBP2 HK2 DHCR24 FABP4 COL3A1 PMC6305196__F9 Model for the CK-dependent photomorphogenic response in etiolated Arabidopsis seedlings RFWD2 DET1 PMC2975941__F2 Classical and non-canonical NFKB pathways CD40 LTBR BCR RELB TRAF3 PMC9038780__F10 Putative synergistic effects of MGO and aSyn in the midbrain CAMK2A IMPACT PMC10931770__F2 Positive and negative regulation of osteoclast differentiation TREM2 CXCL12 MAP3K7IP1 JDP2 EBP PAX5 CX3CL1 NFATC1 ATF4 TRAF6 PMC4312878__F1 Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond ATF3 TLR4 IRF8 PMC8656574__F2 Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application CDH2 CD44 GDF10 FOXO3A HAS2 EZH2 PMC1446957__F5 In vitro keratinocyte mitosis EGF EGFR GRB2 SHE PMC8656574__F1 Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application LATS1 CEBPA BCL2 EZH2 YAP1 PMC9304887__F1 Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery STAT3 AGO2 EGFR MYC PMC6409899__F1 Models of replication-coupled ICL repair FANCD2 MCM7 MCM3 MCM5 FANCM MCM6 MCM2 SLX4 PMC6437054__F1 Interaction map and annotation enrichment of the newly synthesized mazEF-related proteins RHO CLPX PMC6409899__F3 The Fanconi anemia pathway suppresses R-loop-associated genome instability FANCD2 SETX BRCA1 FANCM PMC8009801__F3 Identification of small molecules targeting the Hippo-TAZ/YAP pathway LATS1 BTC AREG MYC RUNX2 PMC9108399__F2 Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRA) in Cancers KLF4 ARTN SNAI1 MTOR SRC PMC9108399__F1 Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRA) in Cancers PSPN GDNF ARTN NRTN GFRA3 GFRA2 GFRA4 RET PMC7532108__F7 Proposed pathway of recovery of R28 cells, induced by hPMSC-derived exosomes, after hypoxic damage UBA2 GSK3B CTNNB1 PMC8781453__SF1 Downregulation of the LncRNA MEG3 Promotes Osteogenic Differentiation of BMSCs and Bone Repairing by Activating Wnt/Beta-Catenin Signaling Pathway DKK1 CTNNB1 PMC2720607__F2 Principal enzymes and substrates of the folate pathway involved in formation of tetrahydrofolate (THF) and its utilisation in the thymidylate cycle DHFR FPGS DHPS PMC4218690__F1 Honokiol and ionizing radiation (IR) affect Notch signaling CDC2 BAX MDM2 MYC PMC3605582__F1 Key mediators of innate and adaptive immunity, development, and signalling STAT3 LTA TLR9 IRAK1 TRAF3 C4A TRAF6 IRAK4 MYD88 TLR4 TLR7 IL12A TLR5 IRF3 IRF7 TNF PREB LTB TLR1 TLR3 C2 STAT4 HLA-B IL23R IL12B TYK2 HLA-A IL12RB1 IL23A PMC3631253__F4 A Protein Prioritization Approach Tailored for the FA/BRCA Pathway DBF4 KIF11 CHFR STK11 STAG3 NCAPD3 ZWINT ORC2 CEP250 SPO11 CCNE1 DMC1 PRC1 ID4 KNTC1 NEK3 SMC2 MDM2 HEL2 HEPACAM PMC2574638__F8 Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer’s Disease BAD IL16 APP PMC4312878__F3 Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond HNRNPAB STAT3 COX2 IL16 IL18 CCL5 PMC10748332__F5 Signaling pathways involved in neuroprotective mechanisms FOXO3A PPA2 MTOR TNF PMC9178153__F2 Autophagy in muscle regeneration: potential therapies for myopathies MYOG PINK1 ULK1 TFEB ATG5 PAX7 SIRT1 PMC4838159__F1 Five significant subnetworks of the N-group, associated with (A) glutathione metabolism (B) leucine and isoleucine metabolism (C) pancreatic cancer (D) calcium signaling pathway and (E) the mitogen-activated protein kinase pathway HEL-S-22 STAT3 TXNDC12 ECHS1 GSTM2 HMGCL HEL-S-21 MGST1 HSD17B10 AACS HEL-S-89n GPX3 VEGFA PPP3CA RAC1 MAPK6 CRK GSTA4 MGST2 NFKB1 CALM1 RPS6KA3 PMC10506243__F5 Protein-protein interaction network and functional enrichment analysis of proteins with acetylation, carbamylation and phosphorylation sites regulated by bacterial lipopolysaccharide (LPS) DDX5 KMT2C MYB HEL113 RANBP1 ANXA2 BAZ1B RPS27A IMPDH2 RANBP2 USP14 DDB1 HSPD1 ACTN4 HEL-S-68p MYH9 RPN1 ENO1 MDH2 EIF4A1 HEL-S-87p HNRNPC CAP1 LMNA PMC4729166__F2 Schematic illustration of the molecular processes leading to apoptosis in renal proximal tubular epithelial cells BAX FAS FADD MYD88 PMC4729166__F1 The activation of the NFKB transcription factor pathway by liposaccharide (LPS), TNFA, high mobility group (HMG)B1, and polymicrobial sepsis HMGB1 CD14 TRAF6 LBP MYD88 PMC8773516__F2 Pathophysiology and Therapeutics of Thoracic Aortic Aneurysm in Marfan Syndrome TGFBR2 SMAD2 SMAD4 TGFBR1 PMC6004386__F1 Binding of S100A8/A9 to toll-like receptor (TLR) 4 triggers the MyD88-dependent pathway, appearing to play a vital role in inflammation TLR4 S100A8 TRAF6 S100A9 MYD88 PMC9525711__F7 Schematic depicting the role of TLB on AD SIRT3 TLR4 TRAF6 MYD88 PMC11856057__F2 Signal transduction in the Hedgehog (Hh) signaling pathway KIF3A KIF7 BOC SUFU DISP1 GSK3B SMO GAS1 GLI3 PMC11856057__F1 General mechanisms involved in Notch signaling MAML1 MAML3 ADAM17 ADAM10 MAML2 HES1 PMC9200284__F2 Adenosine Kinase on Deoxyribonucleic Acid Methylation: Adenosine Receptor-Independent Pathway in Cancer Therapy AK1 ADA PMC9200284__F1 Adenosine Kinase on Deoxyribonucleic Acid Methylation: Adenosine Receptor-Independent Pathway in Cancer Therapy DNMT3B TDG PMC9236768__F7 Jiawei Yanghe Decoction Regulates Bone-Lipid Balance through the BMP-SMAD Signaling Pathway to Promote Osteogenic Differentiation of Bone Mesenchymal Stem Cells SMAD1 DKFZp781O1323 BMP2 SMAD4 RUNX2 PMC8246373__F2 Activity-Dependent Gene Expression in Neurons TF POR PC ARHA PMC1383515__F6 Proposed tentative mechanism underlying MAFA-mediated selective inhibition of FcɛRI-induced cytokine gene transcription JUN FYN FOS PMC6928935__F1 The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway ELF4 RICTOR MTOR DEPTOR PMC9123899__F2 Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA) IFNG IL1R2 STAT3 IL1B PMC6218675__F1 Nuclear envelope proteins and their potential roles in EDMD physiopathology HEL-S-61 SMAD2 SMAD4 ARHA GRB2 LBR PMC9123899__F1 Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA) IFNG IFNGR2 IFNGR1 IFNLR1 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 IL10RB PMC7270498__F2 ncRNAs Regulate Cell Death Pathways to Influence HCC ChemoresistanceMultiple miRNAs and lncRNAs act as mediators of the autophagic process in HCC cells by regulating the PI3K/Akt signaling pathway BAX FAS TP53INP1 ATG16L1 ATG12 ULK1 TNFSF6 PTEN MTOR ATG5 FADD PMC7270498__F1 ncRNAs Affect Drug Efflux and Nrf2-Dependent Drug Metabolism in HCC CellsVarious miRNAs and lncRNAs can regulate intracellular drug concentrations in HCC cells by targeting drug efflux pumps IGF1 KEAP1 DHFR ELL IGF1R PMC8583788__F2 Disentangling Mitochondria in Alzheimer’s Disease TFAM IDE SIRT3 NR1C1 NRF1 SIRT1 PMC8710681__F3 Mitotic and DNA Damage Response Proteins: Maintaining the Genome Stability and Working for the Common Good XPA ATM MDM2 PMC4766464__F9 Loss of CEACAM1, a Tumor-Associated Factor, Attenuates Post-infarction Cardiac Remodeling by Inhibiting Apoptosis BAX ATF4 EIF2A PMC524243__F1 Simplified model of insulin signaling SYP IGFBP1 GRB2 PDK2 PMC4423889__F3 Analysis of Glioblastoma Patients' Plasma Revealed the Presence of MicroRNAs with a Prognostic Impact on Survival and Those of Viral Origin CEBPE TH CDA SPIB MYC PMC3270444__F5 Putative inhibitory pathway of LPS-activated inflammatory signaling responses by peptide K5 TBK1 SYK TLR4 IRF3 SRC TRAF6 FOS MYD88 PMC7279404__F2 Summary of the liquid biopsies activating chemoattraction signal pathways for recruiting immune cells in NASH/NAFLD TNFRSF10B CYP2E1 TLR9 MSC CXCL10 PMC9507402__F2 Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage GSDMD GSDMC GSDMB DFNA5 PMC9507402__F3 Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage GSDMD MCC NLRP3 PMC11724515__F8 Sirtuins 1/3/4/6 exert disparate influences on stem cell differentiation and insulin secretion SIRT3 PDX1 SIRT4 SIRT6 PMC7288973__F8 Schematic diagram depicting the anti-PCa mechanism of C10 BAX CASP8 CASP3 BCL2 IL6 PMC11724515__F1 Mechanism of Sirtuins in the occurrence and development of obesity STAT3 SIRT3 TG SIRT7 ADIPOR1 FOXO1 SIRT1 SIRT6 PMC11724515__F3 Mechanisms by which the FTO and TBX15 genes regulate obesity and osteoporosis MSC RUNX2 SIRT6 PMC11724515__F2 Specific mechanism by which Sirtuins regulate the occurrence of osteoporosis SIRT3 SIRT7 SOST NFATC1 SIRT2 RUNX2 SIRT1 ARX CTNNB1 PMC11724515__F5 Oestrogen, melatonin and NPY on obesity and bone SIRT3 FAS SOST NLRP3 JUNB LEPR NPY RUNX2 SIRT1 CTNNB1 SIRT6 PMC4889582__F2 TLRs reside on the plasma membrane or intracellularly on endosomes and act via the MyD88 or the TRIF pathway leading to the activation of downstream signaling pathways TLR1 TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 TLR7 MYD88 PMC11724515__F4 Vitamin D on obesity and bone TG NLRP3 SIRT1 PMC7805242__F5 MiTF in osteoclast differentiation DCSTAMP CLCN7 GPNMB CTSK OSCAR OSTM1 NFATC1 PMC11724515__F6 SIRT1 regulates the balance between lipogenic and osteogenic differentiation of mesenchymal stem cells ADIPOR1 RUNX2 SIRT1 PMC9204147__F4 Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial LPL CD40 TNFRSF14 CD36 BMP3 CCR2 MMP9 GH1 FGF10 TNF IL25 ANGPTL4 TSHZ1 F3 PDGFC VCAM1 PMC5279777__F3 Transcriptome Analysis Reveals Comprehensive Insights into the Early Immune Response of Large Yellow Croaker (Larimichthys crocea) Induced by Trivalent Bacterial Vaccine NLRP1 NLRP3 CCL4 ARHA TRAF6 IRAK4 PMC7175546__F2 DNA damage and replication checkpoints ATR ATRIP TIMELESS PMC2943133__F2 Toll-like receptor (TLR) signalling is mediated by at least two distinct pathways ECSIT TIRAP IRF3 MIP TRAF6 MYD88 PMC7175546__F1 Participation of WEE1 kinases (Cdk1 inhibitors) and CDC25 phosphatases (Cdk1 activators) in the regulation of the activity of Cdk1 kinase during G2 and M phases CDC2 ATR ATRIP WEE1 PMC6711563__F3 Inhibition of the hedgehog pathway for the treatment of cancer using Itraconazole ABCC1 SOX9 PTCH1 SHH SMO MTOR CCND1 CTNNB1 PMC8507016__F2 Wnt/Beta-catenin signaling pathway in the pathogenesis and treatment of multiple myeloma (review) BCL9 MMP7 APC LRP5 LRP6 FAP CTNNB1 PMC11923325__F5 Downregulation of TLR signaling SOCS1 TIRAP TLR4 CD14 SIGIRR IRAK1 TRAF6 IRAK4 MYD88 PMC8507016__F1 Wnt/Beta-catenin signaling pathway in the pathogenesis and treatment of multiple myeloma (review) BCL9 MMP7 APC LRP5 CTNNB1 PMC3649699__F2 Cerebral ischemia-reperfusion activates two major signaling pathways which exert an effect on NOD IL16 F7 BCL2 PMC8875540__F3 Transcriptomic Analysis of Fish Hosts Responses to Nervous Necrosis Virus NUP133 FUS SMCHD1 SACS EBI3 EPSTI1 RSAD2 DHX58 CTSZ CD8A PMC8507016__F3 Wnt/Beta-catenin signaling pathway in the pathogenesis and treatment of multiple myeloma (review) CCL3 IL7 IL6 PMC6711563__F2 In an adult cell, Hh pathway is always silent or poorly activated SUFU PTCH1 SHH SMO PMC9083465__F11 Integrating Lipidomics and Transcriptomics Reveals the Crosstalk Between Oxidative Stress and Neuroinflammation in Central Nervous System Demyelination TG PC CYBA PMC8909644__F3 Synergistic Anti-Ageing through Senescent Cells Specific Reprogramming GSTM2 GLS PMC11240772__F1 Active Canonical Wnt/Beta-Catenin Signaling Pathway APC LRP5 LRP6 CTNNB1 PMC11240772__F2 Inactive Canonical Wnt/Beta-Catenin Signaling Pathway APC LRP5 LRP6 CTNNB1 PMC11923325__F3 Involvement of TIR domain-containing adaptors in TLR signaling pathways TLR1 TIRAP TLR3 TLR4 TLR9 CD14 IRAK1 TLR5 TLR7 TRAF6 MYD88 PMC11923325__F2 Structure and mechanism of TLR4, highlighting both MyD88-dependent and MyD88-independent pathways TLR4 IRF3 MYD88 PMC5662721__F4 Type I interferon pathway gene network predicted by IPA analysis NNAT SERPINA12 TRIP11 GLS PRPF4 SLC4A7 PKN2 PTEN FABP4 RSAD2 HTATIP2 KRAS KITLG POSTN PRKCI HMGCR CIDEA PI3 CEBPZ TINAGL1 MB CREB1 LBP PMC3754482__F6 Glycocode model: 3-OST-5 and 3-OST-6 regulate distinct cell signaling pathways for ciliogenesis and cilia motility RFX2 FGFR1 KIF3B FGF8 PMC5477485__F2 Conserved insulin-signaling pathway in the ovary IRS4 IGF1R IRS1 PMC4281383__F4 Differential expression in LCI SOCS1 ADAR IFIT1 TANK IFIT3 IFIH1 C1QB TAP1 IFI35 IFNG STAT1 RPS3A RPL17 ZBP1 IFITM3 MX1 TLR7 ISG15 OAS1 IL1B BAX IFITM2 STAT2 PARP14 PSMB8 RPSA IRF9 IFITM1 RPS27A IRF1 IRF7 ZC3HAV1 PIAS1 TNFSF10 TYK2 PMC3990718__F9 Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis MAVS NLRP3 HEL-S-62p IRF3 IL1B PMC7460884__F3 MCSs regulating cholesterol trafficking to the ER NPC2 VAPB NPC1 VAPA PMC6213163__F7 Luteolin and Toll-like receptor signaling pathway CCL7 TLR5 CD68 CSF1R PMC7579710__F6 Potential mechanisms of PB2‐induced apoptosis in OS cells BAX BCL2 CPD PMC6213163__F5 Gene transcription pattern related to the TLR signaling pathway in white adipose tissue CD40 TIRAP CTSK TLR9 CD14 CPO IRF3 IL6 TNF TRAF6 IRAK4 RAC1 TLR3 PDC LBP FADD PMC5477485__F1 Insulin-dependent signal transduction pathways RHEB TSC2 BAD RICTOR TSC1 FYN PTEN MDM2 GRB2 MTOR EIF4E PMC6779911__F6 Configuration of organellar GS-GOGAT cycles and split-organelle arginine biosynthesis ASL PRODH2 FLJ10842 CP CIT PMC9455833__F2 Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets FABP5 FABP4 IL6 IL1B PMC5399176__F8 Proposed mechanism for ion flux-dependent regulation of the NLRP3 inflammasome NLRP3 IL1B PMC5701650__F1 STRESS ADAPTATION HSF1 YAP1 PMC7920050__F1 Biogenesis of exosomes RAB27A RAB27B PMC5843510__F8 Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity IRS4 PMC8330548__F2 Cadmium Exposure on the Immune System and Immunoregulation NR1i1 CD40 NLRP3 KEAP1 PMC2935201__F3 Platelets, Petechiae, and Preservation of the Vascular Wall EGF EGFR VEGFA BDNF CTNNB1 PMC2917385__F1 Tumor Microenvironment in Non-Small Cell Lung Cancer EGFR PTEN MTOR PMC7695978__F1 miR-363 Alleviates Detrusor Fibrosis via the TGFB1/Smad Signaling Pathway by Targeting Col1a2 in Rat Models of STZ-Induced T2DM COL1A2 SMAD2 SMAD4 PMC6357186__F6 KRT19 and Wnt/beta-catenin/Notch signaling pathway in colon and breast cancers NUMB LEF1 RAC1 KRT19 PMC10778261__F8 Modulation of PI3K/AKT/TORC1 signaling pathway and AMPK activity downstream of M2 mAChR activation by APE or N8 in U251 and GB7 cell lines ULK1 MTOR PMC7694542__F3 Conservation of signalling pathway proteins in Myxococcaceae CARF EBP PS1TP5BP1 PMC7379745__F1 Macrophage M2b polarization SYK IRF3 TRAF3 TRAF6 PMC2790417__F10 Summary of proposed role for Foxa2, Nodal and Hh signalling pathways in ventral CNS development FOXH1 NTN1 NODAL FOXA2 PMC7947301__F1 Regulatory activities of nuclear receptors on the NLRP3 inflammasome priming and activation steps NR1i1 PANX1 GSDMD NLRP3 TXNIP CD36 IL18 IL1A IL1B BRCC3 PMC6459338__F3 Classical and “back-door” pathways of androgen biosynthesis HSD17B3 UGT2B15 CYP17A1 CYP11A1 HSD17B2 AKR1C2 AKR1C1 CYP7B1 UGT2B17 STS PMC7921639__F1 Metrnl regulates the intracellular signaling pathway STAT3 METRNL HDAC5 PMC8389593__F4 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway CYP11B2 PCP4 PMC3074690__F1 The current model of the blood coagulation cascade FIBIN TFPI PMC8389593__F3 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway CYP11B2 GSK3B LRP6 PMC8389593__F2 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway KCNJ5 CYP11B2 CACNA1H ATP1A1 PMC8389593__F1 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway CAST STAR CYP11B2 PMC5498918__F1 Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity PRDM16 UCP1 HES1 PMC8389593__F8 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway MED12 GSK3B ZNRF3 LRP6 PMC8389593__F5 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway CYP11B2 HSD3B1 PARP1 PMC2901643__F2 Putative signaling components in fungal mating interactions CDC42 TF PRF1 PMC3206202__F9 Expression Profiling Reveals Differential Gene Induction Underlying Specific and Non-Specific Memory for Pheromones in Mice BAX BAD PMC5393036__F7 Schematic model of NKILA functions during the invasion-metastasis cascade in NSCLC SMAD2 SMAD4 PMC4457722__F5 Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment RAN LMNA PMC11580298__F3 Network-based hub biomarker discovery for glaucoma PDE7B SMG6 DERA FNDC3B EVI1 GMDS ATXN2 ARHGEF3 RERE FMNL2 GLIS3 FARS2 PTHLH CLU ABO LHPP PMC6779911__F2 Functional annotations of highly nitrate-sensitive (HNS) gene set and model of nitrate assimilation and regulatory components in Phaeodactylum tricornutum TF NAT2 TG NONO CS PMC11740368__F5 Pers expression regulates tumorigenesis BMI1 PER3 PER2 WEE1 MDM2 MTOR CCNB1 CTNNB1 PMC4519914__F6 Protein–protein interaction (PPI) network and ingenuity pathway analysis (IPA) TBK1 SP1 EIF4EBP1 EIF1AX TANK IRF3 NCOA1 PABPC1 EIF4E EIF4G1 EIF2S1 BRCA1 ELAVL1 PBDC1 EIF3C SRC DDX3X PMC5814291__F3 FOXC1, the new player in the cancer sandbox EGF EGFR PTCH1 FOXC1 SMO PIN1 PMC5601978__F4 Physiological functions of ataxin-2 INPP5A RPS6 EIF4G1 AGO1 ATXN2 MTOR ELF3 RORA EIF4E PMC11740368__F6 Cancer stem cell generation and mechanisms of PERs action on cancer stem cells PER3 PER2 CTNNB1 PMC3295063__F2 NFKB in Aging and Disease ZAP70 TRADD BCL10 ATM TRAF6 TRAF2 ACR LCK FADD MYD88 PMC8599992__F10 Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability TF PIAS1 TERT SLX4 RBPJ SLX4IP PMC9406090__F2 Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge DIS3L2 LIN28B LIN28A TUT7 TUT4 DROSHA PMC2844177__F9 P38 MAPK signal transduction in melanogenesis MC1R USF1 DCT PMC8777575__F3 Gold complex auranofin: new perspectives for cancer therapy BAX HMGB1 APC PMC8777575__F2 Gold complex auranofin: new perspectives for cancer therapy BAX FOXO3A MCL1 BCL2 MTOR EIF2A ABCG2 PMC4028208__F9 A summary schematic of the lansoprazole-induced AhR/Cyp1a1/Nrf2 pathway in the liver UGT1A3 AHR CYP1A1 PMC1475884__F2 TNF receptor (TNFR) pathway of signaling TRADD TRAF1 TRAF2 FADD PMC11831484__F10 Fatty Acid Oxidation‐Glycolysis Metabolic Transition Affects ECM Homeostasis in Silica‐Induced Pulmonary Fibrosis ACOX1 HK2 PFKM CPT1A PMC4640673__F2 ECM receptors in neuronal structure, synaptic plasticity, and behavior DAB1 VLDLR ARHA PMC4679480__F8 Green Tea component EGCG, Insulin and IGF-1 promote nuclear efflux of atrophy associated transcription factor Foxo1 in skeletal muscle fibers IGF1 FOXO1 IRS1 PMC4346735__F1 Krüppel-like factor KLF10-mediated regulation of transforming growth factor (TGF)B signaling pathway in CD8+ and CD4+ T cells SMAD2 KLF10 FOXP3 PMC9339612__F4 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer MDM2 PMC9339612__F3 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer STAT3 RAN LIF JAK1 PMC9339612__F2 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer SP1 TGFBR1 PMC8379308__F1 Herpesviruses and the Type III Interferon System MED23 TRO ANKRD1 MAVS STAT2 IRF9 TLR9 IRF3 IRF7 STAT1 TLR3 IFNAR1 JAK1 TYK2 PMC9339612__F1 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer RFWD2 STAT3 RAB11A CTNNB1 PMC5386389__F8 ATG5-ATG12 involvement in FMDV-induced type IIFN signal pathway TBK1 ATG12 IRF3 TRAF3 ATG5 PMC4310451__F3 Differential effects of leptin and adiponectin in vascular endothelium CRP STAT3 ADIPOR2 VCAM1 PMC11603874__F11 Anti-TNFR2 bs-Ab mechanism of action EGFR MSC ARG1 PMC7882969__F2 Signal pathways related with androgen synthesis in polycystic ovary syndrome (PCOS) HSD3B2 STAR CYP17A1 INSR CYP11A1 APC GSK3B WNT4 CTNNB1 PMC4661210__F7 JNK1 exerts kinase activity on several transcription factors and BCL2 family proteins through phosphorylation or ubiquitination BAX JUN MCL1 BCL2 BMF ATF2 FOS PMC4661210__F6 Activation mechanisms of the ASK1 signaling pathway leading to JNK and p38MAPK phosphorylation TRAF5 TRAF6 TNF TRAF2 FOS PMC4661210__F3 Activation mechanism of NRF2 and downstream transcription events CES1 KEAP1 GCLM HMOX1 EPHX1 NQO1 GCLC ABCC3 SRXN1 ABCG2 ABCC6 NQO2 ABCC2 PMC6567798__F1 LncRNAs regulate p53 signaling pathway through MDM2 ATM MDM2 PMC3423855__F1 Hepatocellular processing of, and immune modulation by, the precore protein MAL MYD88 PMC7191303__F1 Hippo–YAP1/TAZ pathway in cardiac biology LATS1 FAT4 ARID1A NRG1 LATS2 ERBB4 AMOTL1 NF2 YAP1 PMC5546324__F6 AKT/PKB Signaling: Navigating the Network RHEB EGF TSC2 IGF1 EGFR IGF1R INS TBC1D4 GAB2 IRS1 EIF4E PMC6237576__F3 Contributions of PCAF‐induced acetylation to the development of liver injury and mediators of inflammation APC KLF10 FOXP3 SIRT1 PMC6492362__F7 Gelsolin-like actin-capping protein has prognostic value and promotes tumorigenesis and epithelial-mesenchymal transition via the Hippo signaling pathway in human bladder cancer LATS1 LATS2 HEL-S-66 PMC8905633__F4 Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation STAT3 PIK3CA CHRM1 CCR5 CCR2 CHRM3 HTR2A MAPK8 MAPK3 MAPK14 BCL2L1 P2RY2 ADRA2B IL2 APP SRC MAPK1 JUN TNF NR3C1 AGTR2 CHRM2 HEL-S-162eP CASP3 IL8RB CXCR4 PMC4486162__F1 Apoptosis: role in myeloid cell development BAX FAS TRADD FADD PMC6237576__F4 Contributions of PCAF‐induced acetylation to the development of hepatocellular carcinoma and liver cancer tumour growth BAX HEL-S-162eP PTEN MTOR HEL-S-30 PMC8905633__F7 Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation MAPK1 PLN STAT3 PIK3CA JUN EGFR APP SRC TNF MAPK3 PMC7296212__F6 Mechanism of NRF2 activation by oxidative stress RBX1 KEAP1 PMC3861981__F5 A simplified schematic diagram of the neural circuitry underlying eyeblink conditioning GC PC CS PMC10708062__F8 Analysis of DEGs involved in carbon fixation under osmotic stress RPE RPIA MDH2 PMC3660156__F4 Tumour dormancy and clinical implications in breast cancer EGF EGFR PLG PMC5538252__F4 Sepsis and septic shock MPO PMC6566596__F4 Cross-talks between tumor and immune cells determining chemo-immune-resistance TF PGP PMC8921626__F4 Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach UGT1A1 HEL-S-22 CCNG1 PHLDA3 AOX1 BTG2 PPP1R10 ID1 PMC12006732__F3 Communication between the gut microbiota and other organs FGF8A FXR1 IF2B1 IL13 CYP7A1 FGFR4 TNF PMC11447943__F2 Main interactions of TRPC5 channel with signaling proteins in a cellular context NHERF1 ORAI1 STIM1 TRPC5 NHERF2 GDA PMC3046044__F1 Molecular mechanisms involved in nasopharyngeal carcinoma (NPC) development PTEN UNK PMC3905242__F1 MRE11 complex: starting from the ends CDC2 ATR MRE11A CDK2 ATM BLM PMC6920374__F6 The role of Wnt signaling in hiPSC-CM differentiation SOX17 MESP1 PDGFRA FOXA2 KDR PMC3905242__F4 MRE11 complex: starting from the ends RAD50 MRE11A H2AX ATM PMC6343537__F2 Putative pathway for antagonistic Rab35/Arf6 regulation in presynaptic terminals ACAP2 TBC1D24 RAB13 PMC4054936__F2 Tonic regulation of vascular permeability HGF TIAM1 PAK1 APC RAC1 PMC8509209__F6 LEF1 Enhances the Progression of Colonic Adenocarcinoma via Remodeling the Cell Motility Associated Structures APC GSK3B CTNNB1 PMC10242022__F1 Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis FAS BCKDK PANK1 HEL-S-162eP PPCS PPCDC PMC8282538__F6A Molecular processes mediating hyperhomocysteinemia-induced metabolic reprogramming, redox regulation and growth inhibition in endothelial cells NAGPA ACP2 MOCS3 GPHN SLC2A3 NMNAT2 CLN3 PPCDC HLA-F CTNS PPCS MX1 SLC5A6 TAF1B HLA-C FPGS GBP2 COASY PMC6489690__F4 MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer LATS1 LPA CDC2 MOB1A LZTS1 PMC6489690__F3 MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer AXIN1 SMURF2 WIF1 CTNNB1 PMC8304577__F9 Analysis of Phytohormone Signal Transduction in Sophora alopecuroides under Salt Stress DLAT HMGCR tmp_locus_29 EBP HEL-S-162eP TARP PDC BHMT2 CTH MVD MVK PMC4824422__F3 Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling PLN HTR7 ADORA2A RAF1 OXTR RPS6KA2 BRAF CHRM3 HTR2A MEF2C PRKCB GNAS CACNA1F IL1R2 DRD1 CACNA1I CACNA1G PDE1C CACNA1H NF1 CACNA2D3 CAMK4 GRIN1 GRPR NOS2 PTGER3 CACNA1C ATP2B2 P2RX4 AVPR1A ERBB4 CACNA1B CHRNA7 HRAS GNA14 PLCB1 ADRB2 NTRK1 RPS6KA3 GRB2 BDNF MAPK8IP2 PMC3931400__F3 Signaling by leptin, Wnt, and Beta-catenin in the regulation of Beta-cell proliferation TCF7L2 CCND2 APC GSK3B PTEN SOCS3 CCND1 PITX2 IRS1 CTNNB1 PMC3931400__F2 Signaling by EGF and PDGF in the regulation of Beta-cell proliferation EGF TGFA ERBB4 EGFR EZH2 PTEN EIF4E ERBB3 RHEB TSC2 HBEGF TSC1 BTC ERBB2 PMC5108608__F1 Diagram of possible GPC3-mediated signaling pathway in HCC progression.Abbreviations: GPC-3, glypican-3; HCC, hepatocellular carcinoma; P, Phosphorylation BAD SMAD2 SMAD4 PTEN MMP9 MYC GPC3 RAC1 CTNNB1 PMC8789910__F7 Illustration of proposed mechanism CDC42 AURKA INPP5E RAC1 HDAC6 PMC8940216__F5 Different Roles of Resident and Non-resident Macrophages in Cardiac Fibrosis CCR2 TNF IL1B MYD88 PMC9922515__F7 Solanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway AAMDC ATF4 MYC SESN2 PMC5485992__F2 Neuronal defense systems TFAM IDE GCLM NQO1 FGFR1 PRX APP MTOR BDNF PMC11130840__F1 PCP-mediated signaling pathway in Drosophila and mouse DVL1 CELSR1 VANGL1 CELSR2 DVL3 DVL2 CELSR3 PMC10620037__F4 IL-37 inhibits hepatocellular carcinoma (HCC) RHEB TSC2 MTOR PMC9112923__F5 Identification of Alzheimer’s Disease Molecular Subtypes Based on Parallel Large-Scale Sequencing TF MAPK14 EGF RAF1 CDKN1A EGFR PRKAA2 GRB2 MAPK8 MYC SIRT1 PMC10620037__F3 IL-37 inhibits liver fibrosis TBR1 SMAD1 ID1 PMC4564160__F3 SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells FUS HEL-S-99n HERC1 SACS HSPD1 ETFB HEL-S-125m PARG AMPD3 KIAA0408 KRT9 ATXN2 PMC11901428__F1 Host-microbiota interactome in IBD S1PR1 S1PR3 S1PR2 AHR TLR5 S1PR5 S1PR4 PMC8282538__F5A Molecular processes mediating hyperhomocysteinemia-induced metabolic reprogramming, redox regulation and growth inhibition in endothelial cells SOX17 TRIM13 TRIM16 TSPAN15 PEG10 AGL SPATA20 DEPP1 AKAP12 PMC11899125__F3 Immune-checkpoint signaling CD80 LCK PMC11899125__F1 Signal Transduction Pathways of Co-inhibitory Immune Checkpoints CD80 TIGIT CEACAM1 BTLA LAG3 PMC11899125__F6 Primary resistance CXCL9 EGFR PTEN TOX B2M CTLA4 MTOR CXCL10 LAG3 CTNNB1 PMC4765374__F1 Molecular mechanisms of ethanol-associated OESCC ALDH2 CYP2E1 TLR4 CD14 SHH PMC5974248__F3 Involvement of optineurin in nuclear factor kappa B (NFKB) signaling TBK1 IRAK1 IRF3 IRF7 TRAF6 OPTN IRAK4 MYD88 PMC2864807__F2 PPAR Signaling Pathway and Cancer-Related Proteins in Celiac Disease-Associated Tissue Damage APOC3 FABP2 ACADM PMC2066195__F10 IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice IL1R1 TLR4 IL1B MYD88 PMC9453641__F1 Gamble between oncolytic virus therapy and IFN STAT3 IFNGR2 STAT2 IFNAR2 IRF9 TYK2 PMC8759529__F1 Histiocytoses converge through common pathways CBL ALK PTPN11 MTOR CCND1 PMC12104182__F3 Possible mechanisms by which periodontal pathogens may promote activation of the Wnt/Beta-catenin pathway during oral carcinogenesis DVL1 APC GSK3B PMC2794543__F8 Activation of Wnt/Beta-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells WNT10B GRB2 CTNNB1 PMC9029738__F2 Towards Kinase Inhibitor Therapies for Fragile X Syndrome: Tweaking Twists in the Autism Spectrum Kinase Signaling Network TSC2 TSC1 MAP1B GSK3B ARC MMP9 MTOR EIF4E PMC2751986__F7 Rev-erbA/PGC-1A pathway regulating heme homeostasis ALAS1 NRF1 RORA PMC3622753__F1 Intracellular S100B on cell proliferation, differentiation, survival and motility CDC42 EGF TRIO ARHA PDK2 SRC CCND1 CDK4 S100B PMC7930375__F1 Vitamin D (both D3 and D2) metabolic pathway and its physiological impact on immune cells VIT NR1i1 CYP2R1 CYP27B1 PMC12010983__SF1 Graphical abstract FTH1 FACL4 EZH2 SLC7A11 CXCL3 PF4 PMC4453272__F2 Fragile X Mental retardation protein regulates several cellular functions in the dendritic spine DSCAM RHEB TSC2 AGO1 TSC1 NF1 LIMK1 PTEN PMC9658244__F3 IL-33/ST2 Pathway in Cerebral Malaria IL33 CXCL10 CCL2 IL1B PMC9658244__F2 IL-33/ST2 Pathway in Cerebral Malaria CD40 CD80 IL33 IL5 IL1B PMC8013494__F1 COVID‐19 and Liver Cirrhosis: Focus on the Nonclassical Renin‐Angiotensin System and Implications for Therapy ATR ACE2 PMC8964154__F7 Identifying Active Substances and the Pharmacological Mechanism of Houttuynia cordata Thunb. in Treating Radiation-Induced Lung Injury Based on Network Pharmacology and Molecular Docking Verification BCR ITCH HEL-S-20 EPO CYC1 APP CD19 PTEN PMC4171726__F4 Endothelial versus cancer metabolism GLDC HEL107 GLS HEL-S-162eP GIP PMC9494650__F6 Proteomic and Metabolomic Revealed Differences in the Distribution and Synthesis Mechanism of Aroma Precursors in Yunyan 87 Tobacco Leaf, Stem, and Root at the Seedling Stage ACLY AGA HEL-S-26 ADA PMC9552878__F4 Two facets of receptor tyrosine kinase in cardiovascular calcification—can tyrosine kinase inhibitors benefit cardiovascular system? FGF21 FGFR1 RUNX2 MSX2 FGF23 PMC6316616__F2 HSV-1 deregulates host miRNAs CDC42 IFNG GRSF1 ARHGAP21 CFH IRF1 PMC6444510__F1 cGAS-STING pathway TBK1 CGAS ARF3 IRF3 PMC7203694__F8 Plausible mechanism of CeO2-induced apoptosis of human colon cancer cells (HCT 116) by ROS-generated mitochondrial-mediated pathway CASP3 BCL2 MDM2 APAF1 PMC5486401__F2 Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases BAX TRADD RELA RELB FADD PMC9520222__F8 Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway CDC42 COL6A1 COL1A1 SOX9 COL3A1 PMC11566475__F9 Metabolic pathway gene association network CDC20 SC5D WEE1 TUBB CTGF PMC7550629__F3 TRP- small GTPases signaling pathways interplay in aberrant tumor vascularization TRPC1 ARHA TRPC6 TRPM8 PMC8458655__F9 Research Progress on the Functions and Mechanism of circRNA in Cisplatin Resistance in Tumors STAT3 FXR1 ABCC1 HOXA9 REV3L AK4 PMC8945564__F6 Quantitative Metabolomics of Tissue, Perfusate, and Bile from Rat Livers Subjected to Normothermic Machine Perfusion GAA PC PMC6909348__F2 CLCA1 on mucus production CLCA1 MUC5AC SPDEF PMC4303633__F5 Metabolic scheme of ectoine, glutamate and proline synthesis and catabolism inferred from the Nitrosopumilus genomes ECD PC CS PRODH PMC3920008__F4 Novel regulatory pathway of intracellular lipid homeostasis FAS CYP8B1 CYP27A1 PMC9526673__F6 Identification of Interleukin-1-Beta Inhibitors in Gouty Arthritis Using an Integrated Approach Based on Network Pharmacology, Molecular Docking, and Cell Experiments TH PELO PMC6187079__F1 Mammalian autophagy-lysosomal pathway (ALP) NBR1 ULK1 ATG14 SQSTM1 MTOR CTNNB1 ATG101 ATG10 ATG3 ATG12 TFEB AMBRA1 EVA1A NOTCH1 HDAC6 PMC6955744__F5 TGFB signaling pathway with mediators in the TGFB pathway and BMP pathway are depicted, adapted from IPA NR1i1 TLX2 GSC NODAL GRB2 HOXC8 SKI PITX2 PMC11910004__F7 Epimedium brevicornum Maxim alleviates diabetes osteoporosis by regulating AGE-RAGE signaling pathway TF STAT3 BAX EGR1 PIM1 SELE SMAD2 SMAD4 NFATC1 STAT1 FOXO1 CASP3 MMP2 THBD VCAM1 CDK4 PMC3033158__F3 Signal pathways in systemic regulation of hepcidin TF TFR2 GDF15 HAMP HFE PMC11603874__F8 Signals from Mb-TNFA/TNFR2 stimulate HIF-1A, CXCR4, and PD-L1 BCL9 STAT3 CXCL12 JUN EGFR ATF4 MYC REL CXCR4 CD47 VHL PMC8831980__F2 Fibroblast growth factor 8 in cartilage development and disease APC GRB2 MTOR RAC1 FGF8 CTNNB1 PMC11603874__F7 TNFR2 supports BCSC growth and development CD44 STAT3 SNAI2 EGFR SOX2 HIF1A MYC TRAF2 CD47 PMC11603874__F6 TNFA/TNFR2-mediated invasion and metastasis in BC TME STAT3 CXCR1 HGF EGFR CCR2 IL8RB CCL2 CXCR4 TWIST1 PMC7031469__F1 Action of metformin in the neuro-glial environment BAX TRPA1 ULK1 APP MTOR BDNF SIRT1 CLK1 IL1B PMC11603874__F4 TNFR2/Mb-TNFA signalosome pathway STAT3 TNC CXCL12 EGFR EBP RELB NRP1 PFKFB2 PTEN TAP1 MTOR TRAF6 CTNNB1 SHARPIN COX2 MUC1 TAP2 CYLD TET1 BMX MMP9 IGF1 CXCR4 CCL20 TRAF2 PMC4871335__F2 High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis GLDC ASS1 TDO2 HEL-S-182mP GPT2 PAH HEL-S-61p AFMID GLS2 PRODH GPT PMC4871335__F3 High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis ACLY ELOVL2 CRAT SQLE FASN FADS2 DECR1 HMGCR ACOT4 CROT CYP7A1 ELOVL6 CPT1A PMC3820512__F5 Linking Transcriptional Changes over Time in Stimulated Dendritic Cells to Identify Gene Networks Activated during the Innate Immune Response SOCS1 STAT3 SYK TIRAP PXN AK3 IRAK1 CR2 TRAF3 CTNNB1 MYD88 STAP2 PER3 STAT1 RARA SUMO3 CSNK1E STAT5B ARL1 MDM2 NPAS2 SP1 STAT2 PER2 CSNK1D CXCL16 CXCL2 RBX1 NFKB1 TRAK2 BCL2 CCL4 EP300 CXCR4 UBE2I FADD PMC7384693__F6 Cu-TA’s Biological Targets in MIA PaCa-2 Cells CENPF STAT3 SP1 DDIT3 ERBB2 SKP2 PMC2749448__F1 Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicans GPD2 PDX1 HEL-S-68p GLG1 PGM2 HEL-S-49 FBP1 NDE1 ENO1 PCK1 GPD1 PMC3713536__F2 Anticoagulant and cytoprotective actions of the protein C pathway APC ARHA RAC1 PMC7384693__F2 Overlapping Networks and Selection of Network #7 for Further Analysis KRT18 ERCC1 GTSE1 BTG2 AURKB HDAC5 SFN CBX3 PARP2 KRT19 PMC8599883__F1 Zinc in female reproduction CDC2 NPPC MAPK1 EGFR SMAD2 APC GPR3 MAPK3 MOS PDE3A NPR2 CCNB1 CDC25B PMC7384693__F1 Merged Networks (Core of #1 Overlapping Networks) NUDT13 GRINA GLS PCNA DDIT4 DNTT TANK MYC HMGB3 HMOX1 FBXW7 BTG1 TRIM28 E2F4 CASP4 PDGFC WEE1 ATP23 IL2 ATF4 TMSB4X KDR AHNAK MAML2 ABCC2 BIRC3 CDH10 CITED2 SP1 TBL1X LIF DNAJC6 NFATC1 CBX3 ERG ID3 IP6K2 KDM1A BRCA1 ASB9 DDIT3 ASNS NTHL1 HNF1A BIK PMC2880683__F1 Insulin signaling pathway RICTOR PTEN PDK2 MTOR IRS1 PMC3080979__F2 Partial hepatectomy stimulates anandamide production through a pathway involving conjugation of arachidonic acid and ethanolamine by FAAH FOXM1 PTEN FAAH PMC7286322__F4 LncRNA PTTG3P played different roles in different stages of NSCLC MSH6 ESPL1 MSH2 CDC20 CDC6 SMC3 PRPF40A CCNA2 MYC LSM6 UBE2T SLK FANCD2 CCNE2 SMNDC1 BRCA1 CDC45 USP1 CHEK2 RFC3 MCM2 POLE NCBP2 PMC7951058__F4 Molecular pathway and network analysis of proteomics analysis of differentially expressed proteins in LTLT-Ca mammospheres and LTLT-Ca adherent cells SRP54 SCFD1 TOM7 SCRN1 TIMM44 CSTB SLC44A2 CPPED1 USP30 PELP1 ARPP19 FARSLA CARHSP1 TOMM20 PMC11036065__F2 Molecular targeted therapies for cutaneous squamous cell carcinoma: recent developments and clinical implications RHEB LRP5 TEF PMC4815360__F3 Schematic diagram illustrating synthesis of ET peptides and interaction with receptors ECE1 EDNRA FURIN PMC2077852__F3 Dmp1 links the Rb and p53 pathways BMI1 TBX2 DMP1 JUNB TBX3 MDM2 MYC CCND1 CDK4 PMC8814438__F7 Kinsenoside Protects Against Radiation-Induced Liver Fibrosis via Downregulating Connective Tissue Growth Factor Through TGFB1 Signaling TGFB1 SMAD2 PMC3591094__F8 LPA-LPAR1/3 GAi2–mediated activation of p130Cas in cell migration LPA RHO SRC PMC6769793__F4 Metabolic pathway of classic and non-classic androgens POR HSD3B2 SRD5A2 HSD17B3 CYP17A1 CYP11A1 HSD3B1 HSD11B2 HSD17B2 PMC8924072__F6 Proteomic Analysis Suggests Altered Mitochondrial Metabolic Profile Associated With Diabetic Cardiomyopathy ATP5F1D HEL-S-123m RICTOR HEL-S-271 RPL17 PXN HEL-S-162eP RPS4Y1 CLPP CYC1 HEL-S-87p PMC9453641__F3 Gamble between oncolytic virus therapy and IFN STAT3 PDC IRF3 PMC3682751__F3 Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity INA HEL-S-11 CP PMC3901118__F3 Overview of the Ras/PKA pathway and relevant regulatory connections involved in the yeast pseudohyphal growth and autophagy responses TPK1 MUC1 PMC6949817__F8 Schematic presentation of the CBFB/RUNX3-miR10b-TIAM1 pathway TIAM1 CBFB RUNX3 PMC7395702__F1 Signal Transduction Pathway of PD-1 / PD-L1 LAT GRB2 MTOR PMC6468297__F3 MDM2’s switch from a negative to a positive regulator of p53 following DNA damage is dependent on the p53 mRNA RPL5 RPL11 ATM MDM2 PMC4278616__F2 Signaling modulating adherens junctions (AJs) ARHA RHO RAC1 PMC11959147__F1 Illustration of the PI3K (left) and TP53, inside the nucleus, (right) signaling pathways [21, 22] BAX ATR IGF1 CHEK2 ATM PTEN MDM2 DEPTOR PMC9365119__F1 Non-ionotropic NMDAR signaling in neuronal physiology PANX1 NOS1AP TRPV1 SRC PMC6468297__F1 Cell stress-dependent regulation of alternative initiation of p53 mRNA translation BAX ATM MDM2 PMC7710136__F9 Cross-talk between metabolic, inflammatory and muscle growth pathways in dystrophic muscle CDC42 ESRRA TFAM IFNG RICTOR NR1C1 CYCS HEL-S-28 TNF SIRT1 MEF2C PMC7266940__F3 Deeply characterized cellular processes affected by miRNAs in MB CDK6 SHH SMO MTOR HES1 PMC2613033__F1 Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study ELOVL2 FADS2 FADS1 TNLG7C PMC10459190__F2 Molecular mechanisms involved in atherogenic effects of Cd exposure STAT3 NLRP3 PON1 VCAM1 PMC7210388__F8 GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17 GPR50 MAML1 ADAM17 SP1 HES1 PMC9273281__F1 Senescence-associated secretory phenotype in ovarian cancer dissemination DOT1L CGAS METTL14 METTL3 HMGB2 PMC4250228__F1 Methylation Matters In KRAS Oncogenesis HBEGF EGFR KRAS IL6R PMC9298824__F1 Glimpse of Inflammation and Anti-Inflammation Therapy in Diabetic Kidney Disease CGAS NLRP3 TLR9 AIM2 IRF3 PMC6562901__F1 TGFB Signaling SMAD2 SMAD4 MTOR PMC5702541__F3 MSCs secretome and tumor stemness STAT3 S100A4 EGF CXCL1 SOX2 MMP9 CXCL6 BMP4 BMP2 MSC FOXP2 IL8RB CXCR4 PMC6952548__F7 HCMV miRNA-mediated regulation of TGFB production and signaling during viral latency and reactivation in CD34+ HPCs EGR1 NAB1 HDAC2 CD34 PMC10487916__F3 miRNA–mRNA network based on the target genes of miR-141-3p, miR-150-5p, miR-182-5p, and miR-661 (obtained from the Integrated Breast Cancer Pathway (Wikipathways)) AURKA BMPR1A SMAD4 MAPK8 PLK1 MAPK6 MAPK14 STAT1 ATF1 MDM2 BMPR2 RAD50 MSH2 SP1 VEGFA IRS1 RHEB BARD1 TSC2 TSC1 BRCA1 FOXO1 MAPK7 CDK2 BCL2 GADD45A CDC42 STK11 EGFR PTEN DCAKD FOSL2 HIPK2 CDK7 ATM HIPK1 CCND1 CDK4 BAX DAG1 ZMIZ1 ANXA1 RAC1 MAP3K7IP1 TFPI NFKB1 CASP3 PIAS1 EP300 PMC7374719__F3 Advances in basic research that could lead to the generation of novel therapeutics STAT3 NRG1 NF1 ERBB2 LAT2 TYK2 PMC9355528__F4 Targets and treatments affect oxidative stress in gliomas: An overview of molecular mechanisms SHH IHH ATM MTOR PMC4146646__F11 Schematic summary indicating the mechanism by which Cdt, specifically CdtB, affects the PI-3K signaling pathway and the production of pro-inflammatory cytokines GSK3B TRAF6 MYD88 PMC8257864__F7 Comprehensive analysis of DNA methylation and gene expression profiles in gestational diabetes mellitus DUSP5 MAP4K3 DPYD ME1 PLOD2 PPP1R15B GMPR HSD17B12 PMC8045357__F1 SOCS protein structure SOCS1 SOCS7 SOCS4 MAL SOCS2 IRF3 IRF7 SOCS3 TRAF6 PMC9479325__F5 Integrated analysis of immune parameters, miRNA-mRNA interaction, and immune genes expression in the liver of rainbow trout following infectious hematopoietic necrosis virus infection CD209 RIPK2 TANK IRF3 DHX58 DDX3X MYD88 PMC7210388__F1 GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17 GPR50 MAML1 ADAM17 SP1 PMC7659026__F2 HMGB1 participates in inflammatory processes CXCL12 HMGB1 CXCR4 PMC6827427__F6 TGF-beta signaling pathway annotated by ceRNA pairs of CDKN2B (p15) SMAD1 SMURF1 DKFZp781O1323 SP1 E2F4 SMAD2 ROCK1 SMAD6 ARHA SMURF2 PITX2 TGFBR1 PMC6779479__F12 Proposed disease model of LMNA-DCM RYR2 CAMK2D LMNA PMC6330352__F3 Cartoon depiction illustrating potential saturated free-fatty acid mechanisms that may underlie arrhythmogenic events CSA2 INA TLR4 IL1B PMC6350191__F6 Mitogen-activated protein kinase signaling pathway MAX ECSIT EGF JUN FAS EGFR CD14 FLNA MEF2C NGF EVL MOS NF1 PAK1 NFIB NLK GRB2 TRAF2 TEF PMC6330352__F2 Cardiac and macrophage inflammatory pathways TLR4 IRAK1 TRAF6 IL1B MYD88 PMC3925034__F1 Schematic depiction of some of the Ca2+ channels, pumps and exchangers involved in Ca2+signalling in mammalian cells ORAI1 STIM1 MCU HEL-S-11 PMC11911377__F1 CGAS-STING signaling pathway and its role in innate immunity TBK1 STAT1 STAT2 IFNAR2 IFNAR1 IRF3 CXCL10 TNF PMC3381865__F6 Proposed model for the role of the IGF-1R/NFKB signaling pathway in regulating the caspase-3 differentiation initiation signal BAX BAD IGF1R PMC11911377__F5 HBV evasion and activation of the cGAS-STING pathway KPNA2 CGAS HAT1 PMC6386986__F5 CRPC development FOXA1 SEMA3C BCL2 PMC6178121__F2 Pathway analysis shows apolipoprotein E along with its respective interactions in Parkinson’s disease and schizophrenia pathway LRP8 PPIF HEL-S-62p VLDLR SMAD2 CYC1 SNCA PTEN PSEN1 NEF3 FLNA SLC25A6 CASP3 LDLR BCL2 A2M SRPK2 APP DCTN1 SLC1A1 PMC9322175__F2 Critical Roles of NFKB Signaling Molecules in Bone Metabolism Revealed by Genetic Mutations in Osteopetrosis LTB NFKB1 RELB PMC2423668__F1 Two branches of TLR downstream signaling IRF3 TRAF6 MYD88 PMC6745179__F7 CD28 KO reverses lung blast injury by the PI3K/Akt/FoxO1 signaling pathway CD44 BAX CD2 IL16 CD163 IL1B PMC10451380__F1 Scheme of the NRF2 signaling pathway RBX1 KEAP1 MAF SFN PMC8533980__F5 CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer TBK1 CGAS IRF3 PMC374303__F8 The multiple mechanisms by which HSV-1 blocks cellular IFN-based defense systems STAT1 SP100 PML EIF2A PMC5533325__F5 Dietary lipids on the hepatopancreas transcriptome of Chinese mitten crab (Eriocheir sinensis) CD40 TIRAP CTSK TLR9 CD14 IRF3 TRAF6 IRAK4 RAC1 TLR3 TLR4 LBP FADD PMC7086357__F8 Proposed model depicting the molecular mechanism by which Serelaxin activates Notch signaling pathway to inhibit TGFBeta-induced SMAD2/3 phosphorylation to restore the RXFP1 expression via histone modifications TGFB1 SMAD2 PMC6365411__F1 A) Experimental design depicting the sampling time points represented as days post hatching (dph) during the different gonad developmental stages covered by the study VIT ALDH1A3 CRABP1 RBP4 ALDH1A2 PMC9265711__F1 LIM Kinases, Promising but Reluctant Therapeutic Targets: Chemistry and Preclinical Validation In Vivo CDC42 LIMK2 LIMK1 RHO PMC5321852__F4 Hypothetical TRPC4- / TRPC6-mediated signaling pathway downstream of TGFB1 in InMyoFib cells CDH2 COL1A1 TRPC4 TRPC6 PMC9619486__F1 In silico investigation of the role of vitamins in cancer therapy through inhibition of MCM7 oncoprotein MCM7 CDC45 MCM3 MCM5 MCM6 MCM2 PMC5533325__F6 Dietary lipids on the hepatopancreas transcriptome of Chinese mitten crab (Eriocheir sinensis) IFNG PIM1 EPO IL6 PMC5891947__F1 Potential LMTK2-related neurodegenerative mechanisms in Alzheimer’s disease SMAD2 GSK3B LMTK2 PMC10311566__F1 Recent progress of peptide regulators for the Wnt/Beta-catenin signaling pathway APC LRP5 SMAD4 LRP6 PTH GPR49 CTNNB1 LGR6 PMC8310855__F3 Cannabinoids in the landscape of cancer BAD TRPV2 TRPV1 NUPR1 ATF4 ATF2 ARHA GPR55 TRIB3 TRPM8 PMC8507398__F9 Molecular biology of autoinflammatory diseases TRADD TIRAP OTULIN TAB3 IRAK1 TRAF6 IRAK4 MYD88 SHARPIN RIPK2 MAP3K7IP1 NOD2 TRAF5 RIPK1 NOD1 TRAF2 CYLD PMC8564564__F4 Unfolding the role of autophagy in the cancer metabolism UVRAG MTOR PMC9687868__F3 Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis EGF EGFR HIF1A NF2 MTOR PMC9687868__F2 Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis EGFR CTNNB1 PMC8195994__F7 Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated With Maternal Undernutrition FAS APLN TNF IRS1 PMC9585282__F5 Transcriptomic and metabolic analyses reveal the potential mechanism of increasing steroidal alkaloids in Fritillaria hupehensis through intercropping with Magnolia officinalis ERF MAK PMC3187934__F2 Phosphorylation pathways adapted from KEGG (50)(51) TSC2 TSC1 IGF1R GRB2 MTOR IRS1 PMC4111999__F1 Schematic showing the possible integration of emerging, mass spectrometry-based technologies into the untargeted metabolomic pipeline PMC2491704__F3 Recycling pathway of acetylcholine (ACh) synthesis, release, action and breakdown at a cholinergic nerve terminal ACHE ChAT BCHE PMC6987193__F7 Schematic model based on our results showing the role of E2 in DCIS metastasis to IDC GSDMD IRAK1 MMP3 IL1B MYD88 PMC9289374__F1 Gene expression profile of epithelial–mesenchymal transition in tumours of patients with nonsmall cell lung cancer: the influence of COPD CDH2 SNAI1 SMAD2 SMAD4 ZEB2 MMP9 TWIST1 PMC7287184__F5 Kyoto Encyclopedia of Genes and Genomes (KEGG)-enriched pathways and related genes CDC2 TNFRSF10B CDC20 CDC6 PERP RRM2 SMAD4 SFN CCNA2 PLK1 PTTG1 GTSE1 BCL2L1 PKMYT1 SERPINB5 CDK7 STEAP3 CDC45 TTK CHEK2 CDK2 SESN1 CCND1 YWHAZ PMC4031942__F13 Anti-inflammatory mechanism of C3G is associated with upregulation of the LXRAlpha-ABCG1 pathway which results in disrupting lipid rafts by depleting cholesterol, thereby suppressing the TLR4-mediated NFKB and IRF3 signaling pathways induced by LPS ABCG1 TLR4 IRF3 MYD88 PMC3294670__F7 Mechanisms of control of Listeria entry by the type IA PI 3-kinase signaling pathway DAPP1 SWAP70 RAB5C ARF6 ARAP2 MTOR RAC1 PMC8398409__F6 Reactive Oxygen Species in Host Plant Are Required for an Early Defense Response against Attack of Stagonospora nodorum Berk. Necrotrophic Effectors SnTox PRX TOX3 PMC11746911__F1 Canonical and non-canonical Smad signaling pathways induced by TGFB CDC42 SMAD4 RAC1 PMC4657124__F1 Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PMC9596750__F1 Targeting the inflammasome in Parkinson’s disease NLRP3 TXNIP APC PMC7919800__F1 Insulin-like growth factor (IGF)/IGF-1R signaling pathway in the development of liver disease IGF1 IGF1R IGF2 PMC11746911__F3 Wnt/Beta-catenin and NFKB signaling pathways TLR4 APC LRP5 LRP6 SIRT1 CTNNB1 MYD88 PMC7589301__F1 The possible molecular mechanism of amantadine’s antidepressant effects at the level of dopaminergic and glutamatergic transmission BDNF DDC PMC11746911__F2 VEGF signaling pathway CSF1 VAV2 MTOR CTNNB1 PMC4859887__F2 RTKs mediate DDR through canonical AKT and RAS pathways TOPBP1 ATR BAD BRCA1 ATM PARP1 PMC9266551__F3 Gal-3BP in Viral Infections: An Emerging Role in Severe Acute Respiratory Syndrome Coronavirus 2 TBK1 LGALS3BP IRF3 TRAF3 TRAF6 TNF PMC2952191__F2 mTOR signaling pathway RHEB TSC2 EIF4B TSC1 PTEN MTOR DEPTOR ELF3 EIF4E PMC4859887__F3 Some RTKs regulate DDR through specific canonical pathways ERCC1 CDC2 PCNA EGFR CDK2 PMC11699683__F5 Signaling pathways of UA-mediated antioxidative stress and anti-neuroinflammation in neurodegenerative diseases STAT3 NGF KEAP1 APC AXIN1 LRP5 BDNF CTNNB1 PMC5031174__F7 Diagram showing the regulation of dopaminergic neuronal differentiation of human neural stem cells (hNSCs) PTEN MTOR IRS1 PMC6233178__F1 Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury ROS1 ATF5 NLRP3 ATF4 EIF2A IL1B PMC8634653__F2 Integrins in Gastrointestinal Cancer Metastasis EGF CDH17 EGFR SMAD2 AKT3 PLG GRB2 MTOR PMC10299014__F1 IL-17RA/RC signalling pathways (Figure adapted from Monin and Gaffen , and from Chung ) IL17RC EBP TRAF6 TRAF2 PMC11603363__F2 Pyroptosis and the role of immune and non-immune cells in asthma CARD8 NLRC4 NLRP1 STAT1 GSDMD NLRP3 TLR4 AIM2 PMC8634653__F1 Integrins in Gastrointestinal Cancer Metastasis CDC42 BMI1 SOX2 GSK3B HIF1A RHO RAC1 PMC11603363__F1 Pyroptosis pathways GSDMD GSDMC GZMA GSDMB PMC7672621__F9 Schematic regulatory pathway of linagliptin in OSI-906-induced hepatic steatosis NNMT IGF1 IGF1R PMC8417734__F2 Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases CDC42 ROR1 JUN APC ROR2 LRP5 LRP6 ATF2 ARHA CTNNB1 FBXW7 RNF43 HEL-S-29 ZNRF3 CDK14 GPR49 PMC8417734__F4 Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases CRP SFRP5 BAX CAD WNT3A GSK3B FZD7 MMP9 RHO AXIN2 RAC1 SFRP1 CTNNB1 SFRP4 FZD4 BMP1 MMP2 BCL2 WNT1 WNT3 NFATC3 LEF1 PMC9442994__F9 MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/Beta-catenin signaling pathway CDC42 MICAL2 CTNNB1 PMC3004842__F2 Flux-sum intensity in Z MAL CS TNLG7C CIT PMC12052642__F1 Schematic view of principal anti-tumor effects of resveratrol on different cancer-related mechanisms STAT3 BAX CCND1 CTNNB1 PMC12052642__F3 PI3K signaling pathway in cancer onset and progression BAX BAD AKT3 PTEN MDM2 PMC2213056__F1 AID-initiated SHM pathways MSH6 MSH2 UNG POLN PMC12052642__F2 Major signaling pathways regulated by resveratrol STAT3 KEAP1 APC LRP5 LRP6 PTEN CTNNB1 PMC11699683__F2 UA in antioxidative stress and anti-inflammation NLRP3 TLR4 SLC2A9 PMC6370283__F1 Exogenous pathway of lipid metabolism.apo B-48 = apolipoprotein B-48, apo C-II = apolipoprotein C-II, TG = triglyceride, apo E = apolipoprotein E, LPL = lipoprotein lipase LPL TG APOE PMC6437734__F10 VPA impacts the B cell differentiation into plasma cells and in the isotype switch and maturation affinity of immunoglobulins CD40 PRDM1 CD69 AID PMC6437734__F12 VPA promotes the generation of Treg cells ETS2 FOXP3 PMC6097514__F1 Targetable cell survival mechanisms.Notes: Stimulation of the BCR and its co-receptor CD19 results in downstream signaling via the PI3K/AKT/mTOR pathway SYK BTK BCR PLCG2 CD19 LYN MTOR PMC3431627__F7 Mechanisms of acquired-resistance to vemurafenib BRAF NRAS FGFR3 IGF1R KRAS PMC3825725__F1 Janus face of cyclophosphamide CCND3 BAX IFITM2 STAT2 UBE2L6 CD69 IRF7 CXCL10 DDB2 UNC93B1 CDKN1A MARCO OAS1 SESN2 TYK2 PMC12098830__F6 Other immune signaling pathways in CVDs LATS1 TBK1 LATS2 APC LRP5 LRP6 IRF3 IRF7 CTNNB1 PMC12098830__F8 Integration of key signaling pathway in CVDs with immune response EGF KEAP1 EGFR HEL-S-11 PMC3880546__F1 Physiological regulation of the mTOR pathway STRADA RHEB TSC2 TSC1 PTEN EIF4E PMC3189939__F3 CAFET Algorithm Reveals Wnt/PCP Signature in Lung Squamous Cell Carcinoma CDC42 SFRP4 VANGL1 CAMK2D CELSR2 PRKCA KREMEN1 RYK ARHA CTNNB1 PMC12098830__F4 Innate Immune Signaling pathway in CVDs C6 TBK1 CGAS MAVS HEL-S-62p C1R AKT3 TAB3 TLR9 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 GSDMD RIPK2 NLRP3 ZBP1 TLR4 NOD2 TLR8 NOD1 TLR7 C4B_2 C7 C1S AIM2 TLR5 IFI16 IRF3 IRF7 NLRP12 TLR1 MAP3K7IP1 TLR3 C2 DDX41 PMC9080202__F1 Sestrin2 in cancer: a foe or a friend? TSC2 ULK1 PMC5999604__F1 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma BOC SUFU GSK3B SMO PMC5999604__F4 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma CNOT1 RPS3 GSK3B PMC5999604__F3 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma AURKA B4GALT1 BOC DHH IHH TUG1 SKI NUSAP1 ITGB1 KIF7 PTCH2 SUFU PTCH1 FOXC1 SHH SMO OSR1 RAB23 GLI3 LMNA PMC5999604__F2 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma KIF7 PTCH2 BOC SUFU PTCH1 GSK3B DHH SHH IHH SMO GLI3 PMC8616057__F7 MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells PAX8 BRAF GRB2 RAC1 PMC4733614__F4 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies IFNG CD80 APC OTC PMC4733614__F3 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies STAT3 FH BCR GC POLI CD34 PMC4733614__F2 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies IFNG CD80 APC PMC5328971__F3 Gamma-aminobutyric acid signaling pathway GABARAP HTR4 PLCL1 GABBR2 HTR2A SLC12A2 GABRA6 GABRB1 GABRE GABRA2 PLCL2 ATF4 BDNF PMC4733614__F1 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies SYK BCR IRF9 NFATC1 PMC5286794__F1 Regulation of key cancer stem cell signaling pathways by epigenetic mechanisms HDAC1 SUZ12 EED DKK1 APC LRP5 LRP6 EZH2 HES1 STRAP CTNNB1 PMC6790052__F1 Ciona robusta cardiopharyngeal gene regulatory network and tunicate phylogeny ST14 ST13 ST18 PMC10991369__F6 Comparative transcriptome analysis of Trichoderma reesei reveals different gene regulatory networks induced by synthetic mixtures of glucose and Beta-disaccharide SVIP SEC62 PMC3880546__F2 Pathological regulation of the mTOR pathway in neurological disease STRADA RHEB TSC2 TSC1 PTEN EIF4E PMC3059752__F3 Knowledge-based pathway analysis (Genomatix BiblioSphere Software) indicating the network of high BMI-associated genes RHOU MAF SFN PDZRN3 EFS SOX4 INSIG1 ANTXR2 PMC5404975__F1 Overview of the core components of canonical Hippo signaling LATS1 LATS2 PMC8307462__F1 NMDARs, Coincidence Detectors of Astrocytic and Neuronal Activities PHGDH PSAT1 PSPH PMC5766603__F5 Phenylephrine synthesis SLA ADM NRTN HP PMC5318160__F5 Glucocorticoid-driven network links many of the top-ranked PLSR genes MAPK1 FLT3 PER2 TXK PER1 DDIT4 MTOR DAAM2 MAPK8 CLEC4E MAPK14 FKBP5 NR1D2 GC ZBTB16 CEBPB PMC9136176__F3 Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways STAT3 EGFR PMC3544293__F2 MTOR signaling pathway RHEB TSC2 RICTOR STK11 TSC1 EGFR PTEN MTOR IRS1 PMC6798062__F1 RAS pathway in cancer JUN BAD TIAM1 NF1 RHO SIRT2 MTOR MYC FOS HDAC6 PMC7084352__F4 Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings PRMT1 NOS2 PRMT2 HEL-S-277 ARG1 ARG2 PMC7676208__F7 Potential mechanisms of inflammation by COLEC12 mediated through TLR4 in osteosarcoma COLEC12 HEL-S-62p TLR4 IL18 MPO PMC7084352__F3 Alterations in expression of L-arginine/NO pathway enzymes in inflamed and quiescent tissue from patients with Crohn’s disease as compared to normal small bowel tissue derived from patients with ulcerative colitis PRMT1 NOS2 PRMT2 HEL-S-277 ARG1 PMC7084352__F1 Simplified scheme of L-arginine/NO pathway PRMT1 NOS2 PRMT2 ASL HEL-S-277 OTC ARG1 ARG2 PMC7854359__F4 Conservative route to genome compaction in a miniature annelid LATS1 RHEB MAX TSC2 LATS2 TSC1 MNT MYCL PTEN MTOR MYC TNF PMC3666883__F11 Sonic hedgehog-Dependent Induction of MicroRNA 31 and MicroRNA 150 Regulates Mycobacterium bovis BCG-Driven Toll-Like Receptor 2 Signaling SUFU PTCH1 SHH SMO TRAF1 TRAF3 TRAF2 MYD88 PMC6126377__F2 Schematic diagram illustrates how tilorone and hypoxia may share common mechanisms in the mediation of the preconditioning response TBK1 STAT1 CGAS IFIT1 IFIT3 IRF3 ISG15 TREX1 PMC5054337__F3 Simplified central carbon and amino acid metabolic network MAL CIT PMC6126377__F1 Oxygen sensing HIF prolyl hydroxylases modulate transcriptional and metabolic adaptive responses PDK4 EPO ATF4 TRIB3 PMC10971231__F1 Interplay of signaling pathways: cellular dynamics within the pancreatic ductal adenocarcinoma microenvironment NGF IL33 MMP2 IL6 MMP9 CCL2 PMC10971231__F2 Pivotal role of the NGF/TrkA signaling pathway in PDAC NGF GDNF ACCN3 TRPV1 BDNF PMC8705083__F1 Eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles EIF5A DOHH DHPS PMC5974435__F3 MAPK signaling to the translational machinery ARAF RPS6 EEF2K TSC2 EIF4B BRAF APP DEPTOR PMC11545879__F4 Mechanisms of Tregs in immune checkpoint blockade therapy GIT2 CD226 ZAP70 CD80 TIGIT BATF SMAD2 APC GRB2 FOXP3 TRAF6 PMC2809500__F4 Proteins upregulated during time course analysis in lung or bronchoalveolar lavage fluid (BAL) following intra tracheal instillation of 20 μg carbon nanopaticles (CNP) CRP VWF HEL-S-92n CSF1 EDN1 IL18 FGA THPO CCL1 PMC11019719__F2 Exercise induction at expression immediate early gene (c-Fos, ARC, EGR-1) in the hippocampus: a systematic review STAT3 EGR1 ARC BDNF SIRT1 PMC8037238__F1 Hexosamine Biosynthetic Pathway (HBP) and O-GlcNAc Cycling OGA OGT GNPNAT1 PMC7539786__F6 Scheme showing the activation of the STING pathway by cytosolic DNA and regulation by metformin TBK1 CGAS IRF3 PMC5974435__F2 MTOR and MAPK pathways affect the translatome by modulating the expression of specific subsets of mRNAs CCND3 EEF2K EIF4B MRE11A BRCA1 LARP1 ELF2 EEF2 ATF4 SKP2 TIA1 PMC5974435__F1 MTOR signaling to the translational machinery MAF1 RPS6 EIF4B SGK1 PTEN DEPTOR RHEB TSC2 EEF2K TSC1 NF1 EEF2 TBC1D7 GRB2 SLC38A9 PMC6605043__F1 Probable mechanisms of the effects produced by lncRNAs on TBI.Notes: There are several lncRNAs that have been reported to play different roles in the process of TBI PMC1197416__F6 Several signaling pathways converge to drive actin polarization CDC42 SIM1 SIM2 PMC11124330__F17 This study TLR4 CXCL5 S100A8 S100A9 CXCL3 MYD88 PMC11201820__F2 Interaction between activated ECs and pericytes/vascular smooth-muscle cells (vSMCs) and their targeted inhibitors in red EGF ENG EGFR PTEN MTOR VEGFA PMC11201820__F1 Relevant pathways and their targeted inhibitors (in red) for the EC EGF ENG ANGPT1 EGFR PTEN MTOR VEGFA PMC11668352__F7 Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease NLRP3 TXNIP ATF4 PMC5524151__F1 BDNF signaling is a balance between proBDNF/p75NTR and BDNF in glial cells or inhibit phosphorylation of FL-TrkB thereby preventing stimulation of survival, growth, and neuroplasticity PLG FLT1 BDNF PMC11545879__F2 Various genes expressed by Tregs and their surface molecules CXCL9 CXCR3 CD80 CCL22 MTOR CXCL10 TIGIT CCR4 FOXP3 CCR8 LAG3 CCL1 CCL17 PMC5545931__F6 PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer IGF1R GRB2 PMC6270946__F3A Profiling of Concanavalin A-Binding Glycoproteins in Human Hepatic Stellate Cells Activated with Transforming Growth FactorB1 SVIP USE1 OS9 RBX1 SKP1 ATF4 PMC6358904__F4 Graphical model of IL-1B activation of signaling pathways leading to acquisition of resistance to cisplatin in breast cancer cells EGFR TP63 ATM IL1B CTNNB1 PMC7532081__F6 Diagram illustrates the hypothesis that TP53INP2 modulates cell migration, invasion, and EMT via the GSK-3B/Beta-catenin/Snail1 pathway in bladder cancer.Abbreviation: EMT, epithelial-to-mesenchymal transition TP53INP2 GSK3B CTNNB1 PMC4762928__F1 Glucose and glutamine metabolism in cancer cells GLS HEL-S-133P PMC8671998__F3 Immunogenic ferroptosis and where to find it? HMGB1 TLR4 IL18 TLR9 IL1B PMC8699888__F1 Cellular Senescence in Adrenocortical Biology and Its Disorders CDK6 CDK2 CDK4 PMC5393957__F2 Molecular genetics of osteosarcoma ACLY FASN GSK3B PTEN MTOR EIF4E RHEB TSC2 TSC1 NF1 TFEB GRB2 NF2 PMC9023794__F2 Programmed Cell Death-Dependent Host Defense in Ocular Herpes Simplex Virus Infection RIPK3 ZBP1 TRADD C2 MLKL TRAF5 RIPK1 TRAF2 FADD PMC5370073__F1 Impact of CTLA-4 Ig versus anti-CD28 domain Abs on alloreactive T cell responses CD80 APC TNF PMC11064142__F10 TLR signalling leads to apoptosis in tumour cells BAX TRADD TIRAP STAT2 IRF9 MCL1 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 STAT1 TLR3 IFNAR2 TLR4 IFNAR1 JAK1 TYK2 FADD PMC8181424__F1 Exercise Factors Released by the Liver, Muscle, and Bones Have Promising Therapeutic Potential for Stroke HDAC3 GPR158 BDNF HDAC2 SIRT1 PMC3909253__F9 Bacteria Induce Prolonged PMN Survival via a Phosphatidylcholine-Specific Phospholipase C- and Protein Kinase C-Dependent Mechanism TLR1 TIRAP TLR4 MAL TRAF6 TNF MYD88 PMC12028518__F5 Expression of the GNPDA1 signaling pathway in breast cancer (MetaCore) CDC42 BARD1 NGF ATR RAD50 RAD51 MSH2 NR3A2 BRCA2 ATM ChAT PMC11940432__F2 Intracellular signaling pathways of LGR4 APC LRP5 ZNRF3 LRP6 PITX2 CTNNB1 PMC3891116__F2 Essential cell signaling pathways for prostate cancer (PCa) development and crosstalks between themThe interaction of circulating androgens (T/DHT) with AR is critical for PCa growth DDT STAT3 EGF TRPV3 IGF1 FOXO1 GSTT2 EGFR PTEN HIF1A IL6R PMC8126603__F2 Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19 TBK1 STAT1 MAVS TLR3 STAT2 IRF9 RAE1 IRF3 IRF7 TLR7 NUP98 MYD88 PMC12219279__F5 Exercise ameliorates nonalcoholic fatty liver disease by reducing the IGFBP5 to IGF1 ratio to activate AMPK pathway IGF1 IGFBP5 IGF1R IRS1 PMC9608511__F4 Current insights into the regulation of programmed cell death by TP53 mutation in cancer SLC3A2 GPX4 SLC7A11 HEL-75 ADA PMC9608511__F7 Current insights into the regulation of programmed cell death by TP53 mutation in cancer BAX BAD FAS PMC4631973__F1 PI3K/PTEN/Akt/mTOR-cascade (Modified according to Cingarlini et al and McCubrey et al) RHEB MLST8 TSC2 TSC1 IGF1 PTEN DEPTOR IRS1 PMC9299105__F2 Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19 C1S C4A C4B_2 PMC4747727__F3 Proteomics analysis of exosomes from EBV-driven LCLs compared with exosomes from CD40L-stimulated B cells shows “immune system process” as the most represented pathway, and an enrichment in “integrin-mediated signaling” and “cell adhesion” terms CANX FCER2 MARCKS PTPRC FLOT2 ACADM HLA-DRA FYN F2 CD9 LSR SRC OAS2 CD48 CD2 IFITM2 SCIMP PLXNB2 HEL-S-70p SLC44A2 SPN RPN2 c-fgr ANKH KRT9 BTLA TNIK KRT13 HLA-A CYBB LCK PMC3154047__F1 Activation of mammalian target of rapamycin complex 1 (mTORC1) RHEB MLST8 TSC2 TSC1 MTOR PMC8868482__F1 Involvement of Inflammasome Components in Kidney Disease MAVS NLRP3 TXNIP XBP1 PMC9299105__F4 Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19 IL1R1 HMGB1 NLRP3 IL16 TLR4 IL18 IRAK1 TRAF6 IRAK4 MYD88 PMC4230700__F3 Disseminated cancer cell dormancy: an awakening field BMPR2 CCND3 SMAD1 TGFB1 AXL EGFR SMAD2 BMP7 TGFBR3 TGFBR1 TGFBR2 BMP4 CDK4 PMC9023794__F1 Programmed Cell Death-Dependent Host Defense in Ocular Herpes Simplex Virus Infection BAX BAD LAT BMF EIF2A HRK BIK FADD PMC6823288__F6 Significant KEGG pathways enrichment of DEGs ICOS ATF3 DCC AOX1 CCS INHBA SELE DDIT4 C4BPA EDNRA TTN VCAN PMC7304108__F8 Proposed model by which hsa_circRNA_102610 promotes growth and transforming growth factorB1-induced epithelial-mesenchymal transition of intestinal epithelial cells by sponging hsa-miR-130a-3p CDH2 SMAD4 CCND1 PMC3696739__F3 Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development BMPR1A MMP2 MSX2 CTNNB1 PMC11735109__F11 Schematic representation showing a possible mechanism of YAP1-driven induction of immunosuppression in UCB mediated by the IL-6/STAT3 pathway STAT3 IL8RB YAP1 PMC1176393__F2 Regulatory network of stress responses to drought, salt, and cold: specificity and cross-talk CBL SOS1 SOS2 PMC9561407__F3 Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns SLC3A2 GPX4 LPCAT3 FACL4 SLC7A11 GABPB1 PMC6311104__F2 Steps in miRNA biogenesis AGO4 DGCR8 AGO1 AGO2 DROSHA PMC4180403__F1 Therapeutic Considerations in Treating HER2-Positive Metastatic Breast Cancer BRAF MTOR PMC9629604__F1 IFN activation of the JAK-STAT signaling pathway IFNG STAT1 STAT2 KL PMC11200741__F3 Outline of the Hippo signalling pathway LATS1 LATS2 MYC PMC10896604__F4 Metabolic pathways involved in rectal cancer radioresistance, including significantly upregulated (marked in red) and downregulated (marked in green) abundances of proteins and metabolites in poor responders tumor tissues FH GLS HEL-S-133P PHGDH HK2 HEL-S-162eP SHMT1 HEL-S-51e PMC11200741__F1 Canonical pathway (WNT/Beta-catenin pathway) APC GSK3B LRP5 LRP6 LEF1 CTNNB1 PMC3717794__F2 Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway BAX TIGAR GLS2 PMC3717794__F1 Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway RHEB TSC2 TSC1 PTEN PMC9141140__F4 Rare Variant Analysis and Molecular Dynamics Simulation in Alzheimer’s Disease Identifies Exonic Variants in FLG BACE1 APP FLG PMC11580016__F2 The sources of AHR ligands KYNU KMO AHR PMC11580016__F1 AHR signaling AHR AHRR CYP1B1 SRC PMC5674068__F10 The breast tumor vs mammary gland serial-omics experiment TG RICTOR FASN PC FABP4 GRB2 MTOR ACACA PMC3136711__F2 Qu on cell cycle CDK6 CDK2 CDK4 PMC2096753__F1 Summary of purinergic pathways involved in microglial response NGF PLG IL1B PMC12102305__F9 Graphical abstract shows the unique characteristics of neuron damage in the SN of PD mice due to oligodendrocyte and astrocyte crosstalk GPX4 ATP6V0C FGF9 FGFR1 FGFR3 SLC7A11 COXFA4 FGFR2 PMC7347012__F6 Development of ocular surface ectodermal cell lineages from human induced pluripotent stem cells DKK1 BMP4 PAX6 PMC4401222__F1 TLR4 signaling pathway and its relation with atherosclerosis TLR4 IRF3 TNLG7C MYD88 PMC5961736__F2 Illustration of JAK/STAT signaling pathway that inspires effective therapeutic targets in lymphoma BCL2 MTOR SRC MYC CCND1 PMC7185085__F1 Exogenous LPS directly leads to an increase in the production of white adhesion molecules and other cytokines such as ICAM-1 and vWF VWF ERBB4 TLR4 ERBB2 ARHA IL1B PMC5961736__F1 Illustration of cross-communication network of BCR, PI3K, and NFKB signaling pathways that harbor effective therapeutic targets in lymphoma CD40 SYK BTK BCL10 BCR CARD11 RELA RELB PTEN MTOR MYD88 PMC5961736__F4 PD-1/PD-Ls signaling pathway that acts as effective therapeutic targets in lymphoma ZAP70 APC MTOR PMC3167192__F1 Molecular basics of tumor angiogenesis EPHB4 NOS2 EPO PMC5961736__F3 Apoptosis signaling pathway that contains effective therapeutic targets in lymphoma BAX ATR TRADD BCL2 ATM MDM2 MYC TNF FADD PMC3639415__F8 The regulation and function of MYC in the androgen signaling pathway in molecular apocrine breast cancers MAX FOXA1 TCF7L2 MYC PMC4571974__F9 TRAF6 regulation by arginine methylation PRMT1 JMJD6 IRAK3 TRAF6 PMC6502998__F2 Marè et al FH CAD CS PMC6156235__F6 A schematic illustration of how dipalmitoylphosphatidic acid (DPPA) might inhibit angiogenesis in breast cancer HGF Nbla10317 PMC8389681__F4 Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context SUZ12 HEL-S-36 UBC CREB3 BSCL2 C3AR1 CTH NAMPT POLI HEL-S-51e NANS VCP MVK HRAS SEC31A RAP2A MVD CDC27 USP47 CYLD HSCB HEL-75 RNF139 PMC8389681__F6 Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context CYP51A1 PJA2 PTPN5 ITCH SYVN1 SQLE HERC3 CTSL HEL-S-28 STUB1 B3GAT3 USP20 AMFR DHCR7 TNIK CYLD PMC10222229__F2 Roles of protein phosphatases in liver regeneration STAT3 PFKFB2 PMC4524427__F1 Insulin signaling network that links nutrition to growth and size RHEB TSC2 TSC1 EIF4E PMC4105198__F8 B3 integrin-KRAS-RalB complex drives tumor stemness and resistance to EGFR inhibition TBK1 RALB EGFR KRAS PMC8017223__F1 IL-23 receptor polymorphism associated disorders STAT3 STAT4 TYK2 PMC3610211__F1 TSC/mTORC1 signaling pathway at the neuronal synapse RHEB TSC2 TSC1 FBXO45 NF1 PTEN MTOR EIF4E PMC8861264__F8 Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy TMEM43 CGAS TGFBI TGFB1 GDF15 ATM VCAN LMNA PMC5994257__F11 Schema of signaling pathway involved in HSP60-mediated NLRP3 inflammasome activation and subsequent IL-1B production IL1R1 NLRP3 TLR4 IL1B PMC7530326__F1 TGFB signaling pathway BMP15 BMP10 SMAD1 DKFZp781O1323 SMAD2 SMAD4 NODAL TGFBR2 BAMBI GDF3 GDF11 BMP4 AMH BMPR2 ACVR2B SMAD6 BMP7 GDF6 GDF5 gdf7 BMP6 BMP2 GDF1 BMP5 GDF9 PMC7530326__F3 Dysregulation of BMP-ALK1-Smad4 signaling in HHTs SMAD4 PTEN VEGFA PMC7530326__F2 Dysregulation of TGFB/BMP signaling in CCM KLF4 CD44 BMP6 KLF2 TLR4 CD14 SMAD4 PMC4304911__F3 Regulation of protein synthesis through the mTOR signaling pathway by amino acids and insulin TSC2 TSC1 MTOR IRS1 EIF4E PMC9149051__F2 Figure 2:. Adaptive response programs in tumor cells and in the tumor ecosystem CDC2 ATR RAD51 BRCA1 H2AX EGFR WEE1 CDK2 ATM MTOR IRS1 PMC12116488__F2 Testosterone-AR signaling pathway in HCC immunotherapy IFNG USP18 EZH2 FOXP3 CTNNB1 PMC11276060__F3 LncRNAs in autophagy, apoptosis response, and inflammation of cells to bacterial invasion LTA NLRP3 EZH2 STAT4 MTOR MYD88 PMC12116488__F1 Molecular mechanisms of estrogen signaling in hepatocellular carcinoma (HCC) progression and immune modulation STAT3 SOCS3 PMC11889322__F3 Diagram depicts the Aryl hydrocarbon receptor (AhR) signaling pathway, starting with the cytoplasmic retention of inactive AhR in a complex with heat shock protein 90 (HSP90), X-associated protein 2 (XAP2), and p23 AHR PAH AHRR CYP1B1 CYP1A1 PMC7188081__F1 Advanced Glycation End Products: Building on the Concept of the “Common Soil” in Metabolic Disease GSK3B IRS1 PMC8228386__F2 FGF15 in Hepatic Surgery in the Presence of Tumorigenesis: Dr. Jekyll or Mr. Hyde? FGF8A STAT3 STAT2 FGFR4 PMC8184591__F1 Network of Paf1C Functions POLL PAF1 MSL1 INO80 POLI MSL2 PMC4738716__F5 Network of TREM1 and PTGS2 (COX-2) upstream regulators and their target molecules, evaluated in the peripheral blood cells of breast cancer patients compared with healthy donors (Ingenuity Pathway Analysis) TREM1 CXCL1 ITGA6 NBN PTGS2 AREG IL8RB EGR2 CXCR4 CEBPB FOS CXCL14 PMC9140735__F8 STIM1–Orai1 Interaction Exacerbates LPS-Induced Inflammation and Endoplasmic Reticulum Stress in Bovine Hepatocytes through Store-Operated Calcium Entry ORAI1 STIM1 PMC2841057__F1 Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension ATR IRS1 PMC2841057__F4 Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension ATR IRS1 PMC6314084__F6 Evidence of active A FAS GAR1 MAF TNLG7C PMC4890635__F3 SOX9 is downstream effector of ERG and AR in TMPRSS2:ERG fusion-positive PCa FOXA1 SOX9 ERG CTNNB1 PMC7362612__F1 Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target TBK1 TBKBP1 CASP8 TRADD OTULIN TAB3 TNF PELI1 RIPK3 SHARPIN RIPK1 TRAF1 OPTN TRAF2 CYLD FADD PMC3770140__F2 PHLPP suppresses the PI3K/Akt signalling pathway PTEN MTOR PMC3382482__F1 GFPT1-mediated MTOR signaling pathway affected by glucose and fructose in a pTr cell line RPS6 TSC2 EIF4EBP1 GFPT1 MTOR PMC8642801__F1 DR-5 and DLL-4 mAb Functionalized SLNs of Gamma-Secretase Inhibitors- An Approach for TNBC Treatment DLL4 NRARP MYC PMC8657577__F1 Genetic Variants of the NFKB Pathway: Unraveling the Genetic Architecture of Psoriatic Disease CARD14 TNFRSF1B TNFRSF1A RELA REL TNF PMC3942504__F1 Molecular mechanisms of Bcl-6 expression in T cells IFNG STAT3 ICOS STAT1 FOXO1 PHLPP2 CXCR5 STAT4 PTEN PMC9533579__F3 Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review WNT5B MMP3 CTNNB1 PMC9476775__F5 Brusatol: A potential anti-tumor quassinoid from Brucea javanica CDH2 BAX SQSTM1 MTOR PMC1449730__F2 F igure 2.— C6 F2 F3 PMC5700013__F2 PCSK9 in neuronal apoptosis PCSK9 BAX CASP9 CASP3 BCL2 PMC8745764__F4 COVID-19: Immunohistochemical Analysis of TGFB Signaling Pathways in Pulmonary Fibrosis SMAD2 ACE2 PMC8744613__F6 Energy Sensor AMPKA1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory FOXO1 ULK1 HIF1A PMC11582033__F8 Druggable targets and therapeutic strategies for melanoma treatment BRAF NRAS CTLA4 MTOR PMC11582033__F7 Combination therapy of melanoma using BRAF, MEK, and immune checkpoint inhibitors TH CD80 NRAS CTLA4 PMC6206931__F6 Overview of lipid remodeling in yeast during acid adaptation, where heavy arrows indicate enhanced biosynthesis ID2 PAH POT1 PSD2 PMC11582033__F5 MAPK/ERK signaling pathway and its role in cancer development STAT3 CDKN2A AKT3 BRAF DUSP4 PTEN SRC KRAS CCND1 CDK4 PMC9306810__F3 ODORANT1 targets multiple metabolic networks in petunia flowers CAD C2 CS PMC11582033__F2 BRAF/MAPK pathway TSC2 HGF TSC1 FOXO1 GRB2 MTOR PMC8141029__F1 mTORC1 stimulates SAM synthesis MAX TSC2 INS IMPACT PMC11582033__F1 RTK/RAF/MAPK signaling in melanoma and its effects on immune cell activity CD80 BRAF PMC5380548__F2 Wnt signaling and cellular metabolism in osteoblasts GLS LRP5 LRP6 ATF4 EIF2A PMC5524462__F2 PD-1 is also expressed on T-cells following TCR engagement and activation BATF APC MTOR PMC8502826__F10 Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers ANGPTL8 SAA1 CLEC1B HPD CCN4 HGFAC ORM1 RBP4 CEBPA NNMT NOX3 UNC93A ANGPTL3 ABCC3 PC GCKR RCHY1 PMC3616052__F5 Differentially Expressed Genes during Contrasting Growth Stages of Artemisia annua for Artemisinin Content IPP PMC11524886__F3 Potential mechanisms by which exercise-mediated release of irisin exerts antidepressant effects UCP2 FNDC5 TLR4 UCP1 BDNF MYD88 PMC4637890__F6 IL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway STAT3 ATG14 MTOR PMC11395143__F2 Nrg1/ErbB signaling ERBB3 NRG1 ERBB2 GRB2 MTOR PMC8550604__F1 Factor Xa beyond coagulation TF TFPI GLA PMC7518592__F5 Global gene expression profile under low-temperature conditions in the brain of the grass carp (Ctenopharyngodon idellus) HMGCS1 HMGCR ACAT2 EBP SQLE MVD DHCR7 FDFT1 MVK PMC10915378__F6 Neurodevelopmental and thalamocortical processes involved in epistasis driving spike‐and‐wave discharge (SWD) phenotypes in mice PAK1 DUT TUBGCP4 CTNNB1 PMC11045263__F1 Mechanisms underlying enhanced immunotherapy efficacy through exercise CXCL9 CXCL11 CXCR3 SQLE IL15RA PMC4773745__F1 Inhibition of components of the Shh Pathway in cancer SUFU PTCH1 SOX2 SHH MYC PMC9312812__F5 Emerging Link between Tsc1 and FNIP Co-Chaperones of Hsp90 and Cancer RHEB MLST8 TSC2 TSC1 FNIP2 TTI1 FLCN MTOR FNIP1 DEPTOR PMC7934813__F2 Central role of ACE 2 in SARS-CoV-2 infection and COVID-19 severity TMPRSS2 ATR ACE2 PMC4497429__F1 The PI3K/Akt/mTOR signaling pathway and CSC biology EPCAM RICTOR ABCG2 PMC9312812__F1 Emerging Link between Tsc1 and FNIP Co-Chaperones of Hsp90 and Cancer RHEB TSC2 TSC1 FNIP2 FLCN FNIP1 PMC3382223__F2 Ingenuity Pathway Analysis of altered expression of proinflammatory genes in normal human melanocytes TNLG5A RIPK2 IL12A NFKB1 IF2D CXCL2 CCL2 PMC6135699__F5 Modulating Inflammation through the Negative Regulation of NFKB Signaling TLR4 TAB3 MAL RELA IRAK1 TRAF1 TRAF6 TNF CYLD MYD88 PMC6139543__F11 Proposed alternative metabolic/antidotal pathway of atRAL in the retina RPE LRAT RPE65 PMC6135699__F3 Modulating Inflammation through the Negative Regulation of NFKB Signaling CXCL12 CXCL13 RELB TRAF3 TRAF2 PMC10875024__F6 CCN3 involvement in cell apoptosis and FGFR2 signaling pathways PHF20 ZNF385A FRS2 POU4F2 BANP FRS3 POU4F1 PTPN1 TP63 CCN3 FGFR2 PMC8971671__F8 CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canagliflozin for Cardiorenal Syndrome BAX CX3CR1 SMAD2 ROCK1 CX3CL1 SMAD4 ARHA PMC10875024__F8 Key signaling pathways regulating stem cell pluripotency STAT3 TCF3 SKIL REST BMP4 APC LIF SOX2 NODAL EMB PMC9120357__F3 Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases VPS35 PINK1 HEL-S-130P MFN2 PMC2888634__F4 Drug-induced DNA damage may be repaired by various DNA repair pathways, or apoptosis may be triggered as a result of attempted repair of platinum-induced damage by the Mismatch Repair pathway ERCC1 FANCD2 XPA RAD51 BRCA1 RRM1 DHFR NPRL2 FHIT EME1 XPC HDAC6 PMC5577343__F2 Schematic overview of the 57 meta-signature genes, their literature-based localisation and involvement in the mid-secretory phase endometrium EPHA2 GPX3 EFNA1 MAOA DKK1 ID4 ABCC3 MT1G MMP7 EDN3 APOD SERPING1 ANXA2 G0S2 S100P DEFB1 DYNLT3 SFRP4 C4BPA CRABP2 LAMB3 EDNRB TSPAN8 MAP3K5 ARID5B GADD45A TCN1 CP IL15 COMP HEL-S-62p ACADSB IGFBP1 NNMT OLFM1 CEBPD DPP4 HABP2 SLC1A1 GBP2 GNLY ARG2 AOX1 AQP3 ANXA4 CFD ENPEP CD55 SPP1 IDO1 C2 PRUNE2 BCL6 PMC5787545__F1 Gut microbes on innate immune receptor NLRC4 MLN NPS TLR4 NOD2 MX1 IL17A CP PMC6108866__F4 Role of EpCAM in cell signaling EPCAM APC PC FHL2 LRP6 DKK2 LEF1 CTNNB1 ERAS PMC6463300__F1 HGF/MET signaling pathway CRK HGF RHO GRB2 RAC1 PMC5784884__F5 Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study AGPS GNPAT BAD GPR132 FABP5 CD36 HEL-S-5 BACE1 GSK3B APP KDSR PMC4202148__F6 Silencing of miRNA-148a by hypermethylation activates the integrin-mediated signaling pathway in nasopharyngeal carcinoma ITGB8 VAV2 ROCK1 WASL USF1 PMC5819907__F1 Calcium signaling pathway, with red font indicating target genes PLN CAV3 CAV2 BCR MCU PMC9304552__F3 Metabolic Regulation of Cardiac Regeneration OGA MCAT ERBB4 NAMPT MTOR PDK3 PITX2 CTNNB1 PCK2 ACSL1 NR1C1 PDK4 ERBB2 PMC9439853__F4 Exercise-induced modulation of myokine irisin in bone and cartilage tissue—Positive effects on osteoarthritis: A narrative review STAT3 BMP2 ATF4 RUNX2 PMC8236623__F1 Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance EGF EGFR MTOR PMC8100889__F3 Breast Cancer Therapeutics and Biomarkers: Past, Present, and Future Approaches IPP CDK6 BRCA1 MICA CDK4 PMC7865698__F1 Inflammation and cancer connection pathways STAT3 COX2 ELL IL1B PMC2476215__F3 Brick by brick: metabolism and tumor cell growth FAS GLS HEL-S-133P PMC4631974__F2 Activation of PPARG by bioactive lipids can modulate signaling in progressive colorectal cancer KLF4 MUC1 NOTCH3 PMC6135699__F2 Modulating Inflammation through the Negative Regulation of NFKB Signaling TLR4 TAB3 MAL RELA IRAK1 TRAF6 TNF MYD88 PMC8004172__F2 Molecular components of the host contributing to the modulation of the immune response during human metapneumovirus (hMPV) infection TBK1 TIRAP TAB3 TANK IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TLR4 IFITM3 TLR7 LAG3 PMC1820751__F3 Ras signaling pathway relays growth signals from activated growth factor receptors to the nucleus NF1 CS GRB2 GAB2 PMC5874888__F4 Hypoxia on HIF-1A LONP1 SIAH2 HEL-S-133P HK2 SLC25A1 RPS6KA3 MTOR P4HA1 CTGF VHL PMC3382223__F3 Ingenuity Pathway Analysis of altered expression of proinflammatory genes in normal human melanocytes transduced with Ad-Slug SERPINF2 CCL18 IF2D PROCR BLNK TACR1 PMC8917441__F10 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis CAST HEL-S-69p PTEN HEL-S-11 MYC PMC3996583__F2 Construction of the FB-iPSC-CM regulatory circuit KLF4 RIPPLY2 ISL1 FBRS LIF SOX2 TBX5 GATA4 MEF2C CP PMC9206264__F1 Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-182-5p as a potential expression signature of BRCAness BARD1 BRIP1 RAD51 BRCA1 BRCA2 CHEK2 PMC8917441__F11 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis POR TIRAP CD14 FADD PMC11504336__F2 Complex pathological processes during PCO formation under oxidative stress SMAD2 APC LRP5 SMAD4 LRP6 CTNNB1 PMC9647626__F2 microRNAs associated with the pathogenesis and their role in regulating various signaling pathways during Mycobacterium tuberculosis infection STAT3 EGF TLR1 TGFA MAL BCL2 MTOR TRAF6 TNF FADD MYD88 PMC3240703__F2 Glycosylated Synaptomatrix Regulation of Trans-Synaptic Signaling TG ALK PMC3327812__F7 Protective strategy against hyperinflammatory responses requiring the non-transcriptional actions of GPS2 IL6 GPS2 TRAF2 IRS1 PMC8712703__F6 Attenuating Effect of Low-Intensity Pulsed Ultrasound on Hypoxia-Induced Rat Chondrocyte Damage in TMJ Osteoarthritis Based on TMT Labeling Quantitative Proteomic Analysis BAD VASP FYN HEL-S-28 RHO SHE PMC10244910__F10 Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGFB/Smad signaling pathways TGFBR2 SMAD2 PMC11504336__F3 Role and mechanism of Grx1 and Grx2 in protection against PCO formation CDH2 APC LRP5 HEL-S-28 LRP6 CTNNB1 PMC7312739__F2 Combinatorial treatment approach of Nuclear factorKB (NFKB) inhibition and immune checkpoint blockade IFNG EGFR MUC1 PMC9670202__F2 When the clock ticks wrong with COVID‐19 TMPRSS2 ACE2 PMC7312739__F1 Transcriptional and posttranslational regulation of programmed-death ligand 1 (PD-L1) by Nuclear factorKB (NFKB) IFNG EGFR MUC1 PMC11941770__F1 Differentiation of T helper (Th17) Cells and Interleukin-17A (IL-17A) signaling pathway STAT3 SMAD2 APC TRAF5 TRAF6 TRAF2 PMC9478335__F3 Adipose tissue macrophage in obesity-associated metabolic diseases TNF IRS1 IL1B PMC8110445__F9 拟康氏木霉胞外多糖联合奥沙利铂可体外协同抑制结直肠癌细胞的增殖 SYK MYB BAD COL1A1 F8 CD19 FLJ10842 PTEN PMC9001662__F8 In DR, increased levels of LPS activates the inflammasome in typical and atypical forms GSDMD NLRP3 IL1B PMC5842119__F1 NAD+ intermediates: The biology and therapeutic potential of NMN and NR SIRT7 NAPRT NMNAT1 SIRT4 SIRT5 NMNAT2 NAMPT SIRT2 PARP1 SIRT3 PARP2 SIRT1 NMNAT3 SIRT6 PMC8119568__F1 microRNAs: New-Age Panacea in Cancer Therapeutics RAN DGCR8 DROSHA PMC4041276__F8 Signaling pathways mediating DON-induced RSR, including the MAPK (A, blue), NFKB (B, red), AKT and AMPK pathways (C, green) PDCD11 TSC2 TSC1 GSK3B IL18 MYBBP1A SNIP1 IL6 MTOR SRC PMC6641538__F2 In eukaryotes, iron acquisition is mediated through metal or metal-siderophore transport FXN FECH PMC12197721__F3 Proteins encoded by multigene family genes (MGFs) involved in the NFKB signaling pathway KPNA2 NLRP3 KPNA3 KPNA4 PMC4342984__F6 The figure shows a scheme illustrating the ASARM-model and the pharmacological effects of SPR4-peptide (bimodal) in HYP and wild type mice DMP1 FGF23 PMC12197721__F2 Proteins encoded by multigene family genes (MGFs) involved in the type I IFNs signaling pathway TBK1 STAT1 CGAS MAVS STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IRF7 JAK1 TYK2 PMC3696998__F9 Comparison of CK2 knockout defects and Wnt pathway knockout defects, with a schema to indicate where in the pathway CK2 is believed to act SACS LEF1 CTNNB1 PMC8126961__F3 Is There a Carcinogenic Risk Attached to Vitamin B12 Deficient Diets and What Should We Do About It? Reviewing the Facts DHFR PMC3198803__F5 CcpA Ensures Optimal Metabolic Fitness of Streptococcus pneumoniae GAL PTS NOD2 TBP PMC7930427__F2 Molecular Profiling of Exceptional Responders to Cancer Therapy DDX50 TMUB2 TNC SF3B1 HHIP LAT GSK3B FZD7 BRAF CD14 AMER1 GNAS PLA2G10 IL2RB MNAT1 LEFTY2 THBS4 GRB2 GAS1 HNF1A CDC25B CSF1R GTF2H3 PMC7775471__F3 NAD+ biosynthesis pathways NRK NAPRT HEL-S-90n NAMPT NADSYN1 PMC3198803__F7 CcpA Ensures Optimal Metabolic Fitness of Streptococcus pneumoniae GAL PTS COPA TBP PMC9571692__F1 New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects NQO1 PMC8408558__F8 LINC01189-miR-586-ZEB1 feedback loop regulates breast cancer progression through Wnt/Beta-catenin signaling pathway DKK3 GSK3B LRP6 TCF4 DKK2 SFRP1 CTNNB1 PMC4190587__F3 MicroRNA Regulation of Smooth Muscle Phenotype KLF4 PIM1 CCND2 MYOCD KLF5 ARHA RHO SRC PMC9693225__F3 Shared Proteome of the Apomictic Fern Dryopteris affinis ssp. affinis and Its Sexual Relative Dryopteris oreades SHD PGM2 RIN1 ENO1 EIF4A1 PMC7877184__F8 Morphine-3-glucuronide (M3G) promoting non-small cell lung cancer (NSCLC) immune escape via toll-like receptor 4 (TLR4) and programmed death ligand 1 (PD-L1) TLR4 CD14 MYD88 PMC3715730__F3 Ingenuity pathway analysis (IPA) of Interferon Signaling Pathway of genes differentially expressed in the bronchial epithelial cells exposed to Alternaria alternata spores IFNG STAT1 STAT2 AK2 IRF9 IFIT1 PIAS1 IRF1 PMC4754058__F1 The Notch1 signalling pathway RUNX1 IGF1R NOTCH1 RUNX3 PMC4666670__F4 Transcriptome Analysis of Plant Hormone-Related Tomato (Solanum lycopersicum) Genes in a Sunlight-Type Plant Factory HEL60 LOX PMC7806419__F7 Schematic of the possible signaling pathway of leukocyte immunoglobulin‐like receptor A3 (LILRA3) LILRA3 HLA-G HLA-C PMC4535966__F2 Ingenuity pathway analysis reveals an up-regulation of the NOTCH pathway in LGR5 high SW480 spheres compared to LGR5 low SW480 adherent cells JAG2 NUMB HES1 PMC7751369__F10 Protein-protein and gene-gene interaction networks among CCNB2, CCNE2, CDK4, HOMER1, HSP90AA1, NRAS, PPP2CA, PRKAA2 and RAC1 TEX28P2 HOMER1 TMCC3 PPP2CA CDKN2B CCNA2 HOMER3 RAC1 SGK2 CCNB3 CDKN2A CCNE2 TMCC2 MOB4 CDK6 PRKAA2 TMCC1 NRAS CDK2 PPM1B CDK4 PMC9597306__F5 Recent advances in hydrogels-based osteosarcoma therapy BMP2 MMP2 RUNX2 CTNNB1 PMC5309296__F5 Phosphoproteomic analysis of SK-ChA-1 cells after ZPCL-PDT MAPK1 SOS1 PXN ZYX PAK4 IQGAP1 RPS6KA4 FLNA IRS1 MAPK14 ERBB2 RPS6KA3 BAIAP2 PMC9237413__F5 Proteomic Analysis of Hypothalamus and Pituitary Gland in Pre and Postpubertal Brahman Heifers CDC42 HBEGF CAMK2A LHB GNRHR EGFR MMP2 GRB2 KRAS FSHB PMC10635949__F5 Effect of BD exposure during adolescence on skeletal muscle metabolism and myokine secretion ULK1 FOXO3A FGF21 LIF SPARC MTOR BDNF IRS1 PMC5166973__F7 Targeting translation initiation bypasses signaling crosstalk mechanisms that maintain high MYC levels in colorectal cancer MYC EIF4E PMC12232815__F8 Mechanism diagram of BYHWD TFAM OGDH NAMPT PMC1951533__F14 Proline-Rich Tyrosine Kinase 2 Mediates Gonadotropin-Releasing Hormone Signaling EGR1 LHB GRB2 SRC PMC4339020__F1 TNFA in Cerebral Ischemia: Another Stroke Against You? BAX CASP8 TRADD FADD PMC4645376__F6 Schematic overview of M1 protein-induced IL-8 expression in human keratinocytes TIRAP IRAK1 TRAF6 IRAK4 MYD88 PMC3530555__F5 Combined Inhibition of IGF-1R/IR and Src Family Kinases Enhances Antitumor Effects in Prostate Cancer by Decreasing Activated Survival Pathways IGF1 IGF1R PMC5711528__F2 Interactome of lupus susceptibility genes, constructed using Strings software (version 9.0; http://string-db.org) via evidence‐based protein–protein interactions DNASE1 KIF3A RAB4A XKR6 NCF2 RASGRP3 BANK1 CR2 PRKCA IKZF3 SLC15A4 FCGR2B ICAM3 PRDM1 NMNAT2 IRF7 IRF8 DRAM1 RICTOR ATG16L2 ATG12 CSK DHCR7 IKZF2 NR3B3 TNFAIP3 IFIH1 PPP2CA MTOR GPR19 PRKCB AFF1 TFRC FKBP1A TLR7 C4B_2 ATG5 UBE2L3 FCGR2A RPTOR IKZF1 IL10 IL12A ATG16L1 PLD2 JAZF1 TNLG2B BLK PTPN22 ITGAM SGA56M CD2AP ELF1 WDFY4 TET3 SH2B3 STAT4 LYN TREX1 TYK2 PMC5711528__F1 Metabolic pathways controlling activation and lineage specification in the immune system HEL164 CD44 STAT3 RAB4A VLDLR CD36 LDLR FOXP3 JAK1 PMC2683667__F4 Induction of IFN-signaling pathways in HCV-infected uPA-SCID mice (A) and patients (B) STAT1 IFNGR2 IFNGR1 STAT2 IRF9 F7 IRF3 IRF7 JAK1 TYK2 PMC7871366__F3 Pathway paradigms highlighted by IBD genetics SDF2L1 TRAF3IP2 TMEM258 TNFAIP3 OSM KEAP1 IFIH1 IL2RA IFNG RIPK2 OSMR NOD2 AHR RIPK1 CEBPB IL18RAP FCGR2A IL1B MEFV NOS2 GPR65 BACH2 LACC1 ATG16L1 LRRK2 HGFAC PRDM1 IRGM NCF4 RSPO3 TNF NLRC4 PTPN22 IL17RA RORC NR2A1 NLRP7 STAT4 IL6ST PTGER4 RNF186 IL23R TYK2 CARD9 PMC7232014__F1 Autophagy pathway overview, with childhood-onset neurodegenerative diseases affecting the pathway either directly or indirectly highlighted in red font ATG101 RHEB GABARAP TSC2 SPG11 SNX14 ATG14 MTOR PMC7871366__F2 IBD genes and pathways controlling mucosal immunity CD40 TRAF3IP2 TMEM258 NXPE1 KEAP1 FUT2 ERGIC1 GSDMB IFNG MEFV NOS2 GPR65 LACC1 RFT1 PRDM1 NCF4 RSPO3 SLC22A23 IL23R IL12B TNFAIP3 IFIH1 IL2RA ITGAV PRKCB RIPK2 NOD2 AHR NR5A2 IKZF1 IL10 BACH2 TNLG1B ITGA4 ATG16L1 LRRK2 HGFAC NKX2-3 JAZF1 PTPN22 SLC39A11 RORC NR2A1 SLC39A8 SCAP2 SH2B3 IL6ST STAT4 PTGER4 GCKR RNF186 CARD9 PMC3554558__F1 Putative role of VHL-HIF-EPO pathway in RCC progression EPOR EPO VHL PMC7090218__F2 Metabolic pathways affecting ferroptosis IREB2 CISD1 GPX4 LPCAT3 HEL-S-102 FACL4 SLC7A11 ATG5 ADA PMC7611989__F2 TH effects on hepatic autophagy GNE CAMKK2 ULK1 FUNDC1 MED1 CPT1A PMC4270942__F7 Estrogen Regulates Energy Metabolic Pathway and Upstream AMPK Kinase and Phosphatase Enzyme Expression in Dorsal Vagal Complex Metabolo-Sensory Neurons during Glucostasis and Hypoglycemia FAS PFKL PMC8643130__F2 Gut Microbial-Derived Metabolite Trimethylamine N-Oxide and Atrial Fibrillation: Relationships, Mechanisms, and Therapeutic Strategies NGF NLRP3 IL18 IL1B PMC9250978__F2 Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways TBK1 MAVS IRF3 IRF7 PMC5752873__F1 Wnt signalling pathways and their interactions SIAH2 APC ARHA NLK DAAM1 CTNNB1 PMC3407640__F8 Summary of pathways with differentially expressed genes comparing sarcomas to MSC in the current study CDK2 SMO ARHA CDK4 CTNNB1 PMC9250978__F1 Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways TBK1 CGAS MRE11A DDX41 AIM2 IFI16 IRF3 PMC8468334__F2 Type I Interferons in COVID-19 Pathogenesis MAVS STAT2 IRF9 IRF2 TANK ACE2 PMC4899583__F3 Schematic shows the potential role of epigenetic mechanism that may be involved in manganese induced chronic neurotoxic effects and in pathology of Parkinson's disease BAD FGF20 SNCA PMC6710795__F8 Proposed model of dovitinib-mediated autophagy and apoptosis with regard to the SHP-1/p-STAT3 pathway in breast cells STAT3 MCL1 CCND1 PMC5826526__F5 Eukaryotic initiation factor 2 (eIF2) signaling pathway ELL3 INSR F2 EIF5 GRB2 EIF2A ELF5 ELF3 EIF4E PMC12073636__F1 Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk NPS TLR4 MUC2 INS MYD88 PMC7106760__F8 Schematic illustration of ADAM10 regulates E-cadherin/Beta-catenin signaling pathway which in turn is regulated by miR-122-5p ADAM10 CTNNB1 PMC8161379__F2 Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy PINK1 CERS1 ULK1 ULK2 PMC8161379__F1 Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy CERK SMS SPHK2 tmp_locus_29 SPHK1 HEL-S-5 CER1 PMC6992891__F1 Effect and regulation of the NLRP3 inflammasome during renal fibrosis NLRP3 SMAD2 SMAD4 IL1B PMC2763495__F1 Metabolic pathways of growth and proliferation HEL-S-133P PTEN MYC EIF4E CIT PMC7956893__F5 PPI induces protective autophagy through the PI3K/AKT/mTOR pathway by inhibiting AKT (S473), mTOR (S2448), p70S6K (T389), and 4EBP1 (T37/46) and increasing the conversion of LC3I conversion into LC3II EGF RICTOR MTOR PMC2763495__F4 AMPK–p53 pathway in metabolic adaptation CPT1C TIGAR SCO2 PMC6628043__F7 Biofunction analysis of differentially expressed genes from eWAT (A) Biofunction-overlay of the disease and function related to lipolysis in eWAT; (B) the disease and function in response to CLE in eWAT NR1i1 HCAR2 EGF LEP LPIN2 OSM LGALS12 ADIPOR2 ANXA1 G0S2 PNPLA2 VEGFA TNF LIPA CD44 ACACB ATF3 PRKAA2 PLCL2 LPIN1 ADRB1 ADORA2B STEAP2 PMC5659363__F2 HCMV-encoded agonists of the NFKB signaling pathway IL16 RELA ATM PMC5659363__F1 HCMV-encoded antagonists of the NFKB signalling pathway RELA RELB IL1B PMC3322224__F2 cAMP Signaling CascadeLigand binding (represented in this example by PTH, but other ligands and receptors can stimulate cAMP synthesis), activates GsA and stimulates cAMP synthesis by adenylate cyclase PDE4D PTH PRKAR1A PMC7956893__F2 Anticancer molecular mechanisms of PPs ATF4 MTOR EIF2A PMC7956893__F1 Molecular anticancer mechanisms of PPs STAT3 FAS GSK3B IL6 CTNNB1 PMC7956893__F4 PPs inhibit cancer cell proliferation and induce apoptosis in cancer cells through the NF-kB and MAPK pathways BAX CASP8 EZH2 PMC8656686__F2 PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers TGFBR2 BRD4 CBX2 IGF2BP1 HMGA2 TPD52 YY1 METTL3 IGF2BP2 MTOR TGFBR1 PMC8750516__F1 Targeting the Intrinsic Apoptosis Pathway: A Window of Opportunity for Prostate Cancer BAX BAD BMF HRK BIK PMC5815310__F3 Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease SIRT3 MTOR NOX4 PMC6554677__F1 A model for the regulation of T cell-mediated adaptive immune responses to apoptotic cells CD80 APC PMC2775805__F6 Molecular pathway analysis of genes regulated in the NAc by the HDAC inhibitor MS-275 after chronic social defeat stress REST TGFA STAT2 ADRA1A EGFR RHO JAK1 PMC8656686__F3 PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers BRD4 CBX2 HNRNPA2B1 TPD52 GC PRDX5 CTNNB1 PMC9586150__F3 Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis MAX LEP LIMK1 SPARC PTEN COL3A1 FOS TGFBR1 VCAN POR GNG2 MYLK F3 ADRB2 BMP2 APP TOX PIGS CCND1 PMC9586150__F6 Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis TGFBR2 HEL-S-11 TGFBR1 PMC3724517__F4 Pathway analysis of differentially expressed genes in RAF265 responding versus nonresponding tumors MYB GIPR PICALM PMC9586150__F8 Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis MAPK14 TGFBR2 F3 TGFBR1 PMC7935675__F1 After activation of the S subunit protein on the COVID-19 surface by transmembrane protease serine 2 (TMPRSS2), the virus binds to the Angiotensin-converting enzyme 2 (ACE2) receptor and infects the host cell through endocytosis TMPRSS2 ATR ADAM17 ACE2 PMC2757293__F2 Innate immune evasion by hepatitis C virus and West Nile virus STAT1 IRF3 TRAF3 JAK1 TYK2 PMC5036175__F6 Global Phosphoproteomic Analysis Reveals the Involvement of Phosphorylation in Aflatoxins Biosynthesis in the Pathogenic Fungus Aspergillus flavus PEX19 PC PMC5272809__F2 New View into the Regulation of Purine Metabolism – The Purinosome PAICS HEL-S-70p ADSL PMC5272809__F1 New View into the Regulation of Purine Metabolism – The Purinosome PAICS HEL-S-70p ADSL PMC5526580__F1 Impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer STAT3 HGF IGF1 EGFR IGF1R GRB2 MTOR PMC8858844__F1 Pyroptosis: A Developing Foreland of Ovarian Cancer Treatment NLRC4 GSDMD NLRP3 GZMA GSDMB AIM2 DFNA5 PMC8752857__F4 P38 MAPK pathway in Bactrocera dorsalis MAP3K7 ATF2 MAP3K5 MAP2K3 PMC6349817__F2 Crosstalk between the PI3K-Akt-mTOR pathway and the Hippo-Yap pathway via SIK2 SIK2 AMOTL2 IGF2 PMC8052339__F6 Working model of LPS-induced RAGE signaling in sensory neurons innervating the upper airways IL10 TLR4 TRPV1 IL6 SRC CREB1 PMC6406281__F1 Cholesterol homeostasis in normal cells HMGCR LDLR ABCA1 PMC6273859__F7 Possible signaling pathways for tetrandrine-induced apoptosis in NPC-TW 076 human nasopharyngeal carcinoma cells BAX FAS PMC8364652__F5 Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy BAX ATR ATM ATF4 MDM2 PMC12135389__F1 CGAS-STING pathway and its cellular and disease functions TBK1 CGAS IFNAR2 IFNAR1 IRF3 JAK1 TNF TYK2 PMC8364652__F6 Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy PRDX3 KEAP1 BRCA1 NQO1 ATM KLF14 KRAS LIPG HEL-S-44 PMC7520847__F4 Hedgehog pathway SUFU SHH SMO GLI3 PMC6714236__F7 A schematic model depicting the functions of SNAI3‐AS1 in HCC SMAD2 PMC7520847__F2 Wnt signaling pathway APC AXIN1 LRP5 LRP6 PMC4178212__F2 Activation of p53 is predicted to increase the flux through gluconeogenesis PCK2 PC PCK1 PMC7520847__F1 RAS signaling pathway RHEB TSC2 TSC1 PTEN GRB2 IRS1 PMC4252580__F2 Aldosterone on insulin sensitivity and secretion RAB14 SGK1 ACTN4 IGF1R SRC RAC1 IRS1 PMC8886057__F2 ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids OXCT1 ECHS1 EHHADH ACADSB ACADS PCCB ACADM MCEE ABAT HADHB OXCT2 MCCC2 ACAT2 BCAT2 DLD MCCC1 PMC8894377__F4 Radiotherapy alters expression of molecular targets in prostate cancer in a fractionation- and time-dependent manner ZAP70 EGF LTA TGFA TRADD TIRAP CARD11 RELB TAB3 TANK TRAF6 MYD88 UBE2V1 HEL-S-71 NGF MAP3K7IP1 RELA LCK FADD PMC6769012__F6 BK ablation attenuates osteoblast bone formation via integrin pathway RAF1 SRC RUNX2 PMC6871180__F3 Molecular mechanisms of arrhythmogenic cardiomyopathy LATS1 LATS2 GSK3B NF2 PMC11566304__F1 Metabolic pathway diagram of hypoxanthine PURA PURB THRA PMC10918650__F1 l-isoleucine biosynthetic pathway in E NR1A2 THRA PMC12103977__F1 Comparative framework for the integrative analysis of cardiovascular phenotypes MYH7 PMC3916222__F2 Mathematical Modeling of the Phoenix Rising Pathway C7 HEL-S-62p COX2 PMC4209854__F1 EGFR signalling in chronic lung disease EGF HBEGF TGFA IER2 PMC3589091__F1 Pathways of PI5P synthesis and turnover FIG4 PI3 PIKFYVE PMC9297570__F5 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states EGFR ERBB2 IMPACT PMC4574301__F1 Intestinal epithelial barrier function plays an essential role in maintaining intestinal health IF2B1 TTC7A ADAM17 IKBKG PMC11053710__F2 Cross-talk of Dyrk1B in signaling pathways in development and disease PTCH1 DYRK1B SMO MTOR KRAS RLF GLI3 PMC7200761__F7 Loss of HAT1 expression confers BRAFV600E inhibitor resistance to melanoma cells by activating MAPK signaling via IGF1R HAT1 BRAF IGF1R PMC8002730__F3 Core signaling pathways of triple negative breast cancer (TNBC) CDC42 STAT3 ILDR2 HIF1A TP53INP2 CCL28 MTDH MGAT4A MMP2 ERBB2 BCL2 EP300 CXCR4 HEL-S-26 PMC6797170__F5 Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach RAN AXL LIPN CP PMC3398464__F1 Key branches of the insulin signaling cascade RHEB APOC3 TSC2 PDPK1 PTEN GRB2 SULF2 NOX4 IRS1 PMC8002730__F5 Common and distinctive core signaling pathways between triple negative breast cancer (TNBC) and non-triple negative breast cancer (non-TNBC) CDC42 S100A4 PGR ILDR2 MAPK9 MYC RAP2C TP53INP2 CCL28 MTDH MMP2 ERBB2 BCL2 ARRDC3 EP300 GABARAPL2 CXCR4 PMC9134593__F1 Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases TBK1 TAB3 MAL TLR9 IRAK1 TLR5 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 TLR10 IL1B PMC8002730__F4 Core signaling pathways of non-triple negative breast cancer (non-TNBC) CDC42 RAP2C TP53INP2 CCL28 PGR ILDR2 MMP2 BCL2 EP300 GABARAPL2 MYC CXCR4 PMC6797170__F7 Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach VWF SERPINC1 SERPINF2 F5 SERPINA1 PLG F7 F11 TFPI F2 F10 F3 THBD A2M F8 F9 PMC9134593__F3 Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases TBK1 MAVS TRADD IRF3 IRF7 TRAF3 TRAF6 TRAF2 IL1B PMC9134593__F2 Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases MAVS IL13 NLRP10 TAB3 IRF3 IRF7 TRAF3 NLRC4 NLRP1 NAIP NLRP12 GSDMD RIPK2 MAP3K7IP1 NLRP7 NLRP6 NLRP3 IL16 NLRC3 PMC4559511__F2 Complement and adaptive immunity IFNG CD80 BCR HEL-S-62p APC CR2 PMC8321669__F10 RNA-seq analysis indicates Chemical carcinogenesis inhibition in M3−/− crypts CYRIA MAL ME1 SKI PMC6797170__F4 Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach MAK FRK HEL111 APC HRG CS POR AHSG c-fgr APOH FGA LBP CP PMC4559511__F1 Complement cascade HEL-S-62p C2 PMC11464740__F3 JAK/STAT signaling pathway can be activated or inhibited by inflammatory cytokines to regulate the inflammation of UC IFNG TYK2 PMC6044892__F8 Speculated biosynthesis pathways of glycosylated products elongated on a saccharide primer GAL CS PMC11894581__F6 PPI networks HSPG2 C1QTNF3 TMPRSS11E FHL2 VTN NUMB ZNF185 POSTN CTBP2 ADAM17 OLFML3 PROS1 HABP2 HEL-S-1 CEBPB MAP2K3 VWF GPC4 JUNB KRT85 NFATC1 FABP4 SPP1 SFRP1 MYOC MFAP4 SPCS3 RPS9 PMC5877513__F3 An overview of resveratrol-mediated targeting of multiple signaling pathways SIRT7 ANGPTL4 SMAD2 APC GSK3B LRP5 SMAD4 LRP6 CXCL8 CTNNB1 PMC4423606__F4 Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models PGAM1 PFKFB1 HEL-S-49 HEL-S-87p PMC5877513__F1 TGF/TGFR signaling axis SIRT7 ANGPTL4 SMAD2 SMAD4 CXCL8 PMC9297570__F2 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states EGFR ERBB2 IMPACT PMC9297570__F4 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states HGF STAT5B ERBB2 IMPACT PMC6307166__F4 CircRNA-miRNA interactions are potentially involved in the initiation and progression of CRC SPRY2 PIK3CA PI3 EGFR APC IRS1 PMC9297570__F3 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states MUSK APC IMPACT PMC11816596__F1 Canonical Wnt pathway (left): Wnt ligands (such as Wnt1, Wnt2, Wnt3, Wnt3a, and Wnt 8) bind to the frizzled (FZD) receptor and its coreceptors LRP5/6 (LDL-receptor-related proteins) APC ROR2 GSK3B ARHA RAC1 CTNNB1 PMC2700428__F2 Some cellular processes implicated in the pathogenesis of PAH BMPR2 EGF KDR PMC3202302__F1 Signaling by the TNFR superfamily in B-cell biology and disease CD40 NFKB1 GC TRAF2 PMC5101203__F1 Putative pathological production of AB and NFKB signaling in neurons EGR1 BACE1 NPY EGR2 BDNF PMC3202302__F2 Signaling by the TNFR superfamily in B-cell biology and disease CD40 BCR RELB PMC3202302__F5 Signaling by the TNFR superfamily in B-cell biology and disease CD40 TRAF3 TRAF6 TRAF2 PMC6216024__F1 Hedgehog signaling pathway KIF7 SUFU SMO PMC3202302__F4 Signaling by the TNFR superfamily in B-cell biology and disease SYK BAD RELB GSK3B BLNK PTEN CD19 TRAF3 STS BTK FOXO1 PLCG2 PI3 TRAF2 PMC9362470__F1 Sulfide metabolite formation and fate CYS1 CTH ETHE1 PMC9044756__F10 Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer APC CTNNB1 PMC5523822__F2 Altered B cell signalling in autoimmunity CD40 PTPN22 BCR WAS PMC8617922__F1 Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm SUMO1 SOCS3 IL6 PMC9433872__F6 Research progress on RNA−binding proteins in breast cancer LATS1 VASP HMGA2 MSI2 MYC CREB1 PMC9120625__AF1 Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression RB1 GSK3B BDNF CTNNB1 PMC3175751__F2 Schematic Overview of Nodal and Cripto-1 Signaling Pathways SMAD2 SMAD4 NODAL SRC PMC3188749__F3 Simplified schematic presentation of the transcriptional hierarchy of essential factors and signaling pathways during endocrine specification of the pancreatic endoderm PROX1 PDX1 PAX4 PMC4118249__F9 Theoretical structure of this triple-hit nALI model as a translational study TLR4 AREG MYD88 PMC6173119__F2 Regulation of intestinal cholesterol absorption and role of the Niemann-Pick C1-like 1 protein (NPC1L1) at the enterocyte level in humans TG ABCG8 ABCG5 MTTP HMGCR ACAT2 NPC1L1 HEL-S-5 FABP4 PMC8703276__F1 Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks DHFR PMC2723786__F1 BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells CD40 ATR CHEK1 ATM IRF4 BCL6 PMC4865891__F6 Loss of Interleukin-21 Receptor Activation in Hypoxic Endothelial Cells Impairs Perfusion Recovery after Hindlimb Ischemia IL-21 STAT3 BAX PMC7486457__F8 Proposed model for the relationship between NRF2-FOCAD-FAK signaling and cysteine deprivation-induced ferroptosis FTH1 FTL GPX4 RPA1 AKR1B1 PMC9661362__F2 Central Adiponectin Signaling – A Metabolic Regulator in Support of Brain Plasticity TSC2 NR1C1 TSC1 APPL1 ADIPOR1 ADIPOR2 INS PMC7352710__F1 A-proliferation inducing ligand/B cell maturation antigen (APRIL/BCMA) pathway and its biological effect in the multiple myeloma bone marrow microenvironment TG CCL3 MCL1 BCL2 FOXP3 CCND1 BIRC3 PMC6347560__F1 Ribosomal stress (RS) pathway and its hypothetical role in neurodevelopmental syndromes POLL NPM1 POLI MDM2 PMC8546207__F4 Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development CD40 CD80 VCAM1 TNF IL1B PMC3931013__F3 Wnt signaling pathway represented by KEGG analysis PLCB4 NFATC2 CHD8 GSK3B SMAD4 MAPK9 TCF4 APC2 RAC3 CTNNB1 FZD3 DKK1 ROCK1 SENP2 PLCB3 CCND1 MMP7 NFATC4 FZD2 TBL1X APC LRP5 FZD7 LRP6 TCF7L1 SFRP1 NFAT5 CER1 CREBBP PLCB2 EP300 NLK WIF1 PMC7325303__F1 Apoptosis in health and disease: the balancing act of BCL-2 family proteins BAD MCL1 BCL2 MYC HRK APAF1 PMC3736724__F1 Tyrosine kinase (TYK) targeting growth factor and proliferation pathways CRK VEGFB PIGF RAF1 NRP1 CSK FLT1 KDR ITGAV FGF2 PMC6824075__F10 Working model for the SULF2‐LAPTM4B‐dependent autophagic pathway in HCC cells LAPTM4B SULF2 PMC8898188__F1 Cross-Communication Between Knee Osteoarthritis and Fibrosis: Molecular Pathways and Key Molecules SOX9 APC GSK3B FOXC1 NLK CTNNB1 PMC8533955__F2 Towards Understanding the Direct and Indirect Actions of Growth Hormone in Controlling Hepatocyte Carbohydrate and Lipid Metabolism IGF1 INS PMC9185410__F3 Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion HMGB1 MLKL IL33 PMC3263503__F8 Schematic depiction of crosstalk between Notch and HIF-1A STAT3 HEL-S-68p CREBBP VHL EIF4E PMC7968318__F4 VIRMA and circ_KIAA1429 involved in human cancer progression CDC2 ID2 VIRMA MYC TNF GATA3 PMC7505271__F4 Relationships between mitochondrial and norepinephrine dysfunctions ALDH2 HEL-S-62p DBH C9 PMC6752849__F10 Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor GSK3B AHR CTNNB1 PMC3691204__F1 Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma HHIP KIF7 PTCH2 SUFU PTCH1 SMO GLI3 PMC11274091__F3 Interrelationship of major pathways and coexisting inflammatory mediators between oxidative stress and inflammatory process in excisional skin wound healing CRP IL10 NLRP3 COX2 LPO IL6 REL MPO PMC8022410__F8 GSK3B rephosphorylation rescues ALPL deficiency-induced impairment of odontoblastic differentiation of DPSCs DSPP DMP1 GSK3B CTNNB1 PMC4509139__F3 Map of the Wnt signaling pathway, which includes at least three Wnt signaling pathways, namely the canonical pathway, the planar cell polarity pathway and the Wnt/Ca2+pathway BAMBI SOST ING4 ROCK2 APC CER1 SMAD4 SKP1 ARHA NLK DAAM1 CTNNB1 PMC11203986__F10 DAXX-associated pathway SETDB1 SUV39H1 PMC8155577__F2 Ancient Adversary – HERV-K (HML-2) in Cancer TF IL10 MAVS TLR3 TLR8 IRF3 IRF7 MDM2 CTNNB1 PMC7005898__F6 Proposed function of HadDMtb in the mycolic acid biosynthetic pathway of M C2 PMC8222669__F2 Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases RBX1 KEAP1 NQO1 GCLC MAF AKR1C1 NOX4 PMC9508752__F3 Profiles of transcriptome and metabolic pathways after hypobaric hypoxia exposure TES TH AGA PMC8222669__F6 Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases STAT3 KEAP1 MTOR PMC6361458__F5 Molecular insights in the pathogenesis of classical Ehlers-Danlos syndrome from transcriptome-wide expression profiling of patients’ skin fibroblasts SVIP HEL-S-62p DNAJB7 DTL CLSPN IGFBP2 SPP1 EDIL3 C14orf133 ATG10 POSTN CCNE2 CDKN1A DIPLA1 ALG13 PMC7505271__F2 Relationships between mitochondrial and serotoninergic dysfunctions HEL-S-62p GSK3B C9 PMC6028704__F1 Sub-network with a size cut-off of 28 between D-glucose and L-phenylalanine in S PC PHETA1 GIP CIT PMC9468880__F2 Recent advances of the mammalian target of rapamycin signaling in mesenchymal stem cells RHEB EEF2K TSC2 RICTOR TSC1 SGK1 PTEN MTOR CASTOR1 MSX2 EIF4E PMC10353343__F4 Gene expression changes for genes in the Toll-like receptor 4 (TLR4) Signaling Pathway ECSIT BTK TAB3 MAL CD14 IRAK1 IL6 VCAM1 TRAF6 LBP MYD88 PMC6526306__F6 BCAA mediate resilience to stress by inducing the hippocampal BNDF/TRKB signaling through the PGC1a/FNDC5 pathway HPD FNDC5 BDNF PMC3858599__F1 NAD+ metabolism, a therapeutic target for age-related metabolic disease NRK HEL-S-90n COCH NAMPT PMC4570748__F7 Redox control of the cellular energy metabolism ATM HIF1A MTOR PMC2374962__F2 Regulation of glycolysis and fatty acid synthesis FASN TIGAR SCO2 CPT1A PMC8832002__F7 S100A4/TCF Complex Transcription Regulation Drives Epithelial-Mesenchymal Transition in Chronic Sinusitis Through Wnt/GSK-3B/Beta-Catenin Signaling CDH2 S100A4 COL1A1 APC GSK3B LRP5 LRP6 TCF4 CTNNB1 PMC3789189__F8 CVB3-induced the PI3K-Akt-mTOR-apoptosis signaling pathway TSC2 TSC1 PMC4102553__F5 Serum Metabolomic Response of Myasthenia Gravis Patients to Chronic Prednisone Treatment LOX COX1 COX2 PMC4102553__F4 Serum Metabolomic Response of Myasthenia Gravis Patients to Chronic Prednisone Treatment HEL110 ARSI ALOX12 PMC6321704__F1 Simplified reference TLR signaling pathway projected onto putative homologs in Trichoplax sp TRAF4 TAB3 IRF3 IRF4 PMC3822957__F11 P60TRP signalling based on the results obtained from different systems including NSCs, PC12 cells and p60TRP transgenic mice CDH2 CDK5 BACE1 APP ADAM10 MAP2 NOTCH1 PMC3975365__F3 So-called PI3-K/Akt/mTOR survival pathway RHEB BAX TSC2 BAD TSC1 C9 PTEN MDM2 MYT1 MTOR RAC1 PMC2812788__F1 HDL, ABCA1 and ABCG1 transporters in cholesterol efflux and immune responses ABCG1 TLR4 CD14 ABCA1 IL1B MYD88 PMC3975365__F2 Tumor’s interaction with its solid microenvironment BAD GRB2 SRC CTNNB1 PMC3975365__F1 Apoptosis induction and signaling CAD SET PMC3752265__F5 Example of differences in use between glycolysis and the ED pathway by representative cells in our modeled population RPE LDHD TNLG7C PMC7533558__F9 How CRLF1 promotes HLF formation CRLF1 MMP2 HLF IL1B PMC7792207__F4 Survivin and interaction with apoptotic pathways PAF1 XAF1 FADD PMC7912776__F1 Genetics of extreme human longevity to guide drug discovery for healthy ageing RHEB TSC2 TSC1 IGF1 INSR GSK3B LRP5 TBC1D7 LRP6 GRB2 IRS1 PMC5466966__F1 Major Anti-tumorigenic pharmacological properties of thymoquinone STAT3 BCL2 MMP9 SRC CDK4 PMC5650339__F8 miR-146a promotes growth of osteosarcoma cells by targeting ZNRF3/GSK-3B/Beta-catenin signaling pathway AGO2 GSK3B ZNRF3 CTNNB1 PMC7792207__F3 Pathway involving the non-canonical NF-kB activation through NF-kB-inducing kinase (NIK/MAP3K14), modulated by cIAPs CD40 RELB TRAF3 TRAF2 PMC3979117__F1 Schematic illustration summarizing apoptotic signaling through the death receptor pathway and the mitochondrial pathway MDM4 BAD FAS MDM2 SIRT1 PMC10971254__F8 Binding of IL-25 to its receptor induces the transcription of IL-25 responsive genes via the TRAF6/NFKB-dependent signaling cascade and TRAF4/MAPK/AP-1-dependent signaling pathway TRAF4 IL25 IL17RB TRAF6 PMC8540239__F3 An Insight into Anti-Inflammatory Activities and Inflammation Related Diseases of Anthocyanins: A Review of Both In Vivo and In Vitro Investigations TIRAP CD14 TRAF6 LBP PMC4574248__F2 Signal transduction pathways and the oxidative stress response CDK8 MED13 CCNC PMC8065760__F3 Involvement of the significantly dysregulated microRNAs in renal cancer signaling pathways EGF EGFR MTOR VHL PMC1168613__F1 Comparison of the D REL FADD MYD88 PMC11711753__F6 Extending a canonical pathway with PTMNavigator CDC2 MAPK1 CIC NUP214 RAF1 ROCK2 SOS1 GSK3B BRAF RPS6KA1 YBX1 ARHA MAPK6 MAPK3 MAPK4 ERF MOS SOS2 ROCK1 ARHGEF7 MAP2K1 MAP2K2 SGTA PMC11711753__F4 Analysis of a phosphoproteomic perturbation dataset in PTMNavigator RPS6 RPTOR EGFR GSK3B BRAF MTOR MYC IRS1 EIF4E RHEB TSC2 RICTOR TBC1D7 GRB2 PMC9502658__F2 Ivermectin: A Controversial Focal Point during the COVID-19 Pandemic TMPRSS2 IRF3 IRF7 ACE2 PMC3735083__F1 HIF-1A regulation in cancer CDC2 KLHL20 PML MTOR PIN1 PMC7910460__F4 Crosstalk between HIFs and mitochondrial dysfunctions in cancer development NPAS2 TG NR1C1 PINK1 MFN2 HEL-S-51e MXI1 VHL PMC9108985__F1 Cellular proteostasis in antitumor immunity HSF1 PMC4292903__F2 Biomarkers Linking PCB Exposure and Obesity FGF7A FOXO1 NODAL FOXD4 FGF2 CP PMC4607614__F6 Schematic representation of SA’s mechanisms of suppression of HMGB1’s proinflammatory activities HMGB1 TLR4 CXCR4 PMC3739146__F7 NAC protects against Cd-induced germ cell apoptosis by inhibiting UPR signalling in the testes CD2 EIF2A XBP1 PMC6885792__F2 The role of MYOF in membrane trafficking MYOF EGFR VEGFA PMC8170419__F3 Intersectional analysis of chronic mild stress-induced lncRNA-mRNA interaction networks in rat hippocampus reveals potential anti-depression/anxiety drug targets MEA1 OMP SI ChAT SHE PMC6885792__F3 Role of MYOF in EGFR-related pathway EGF MYOF EGFR PMC8255612__F1 BMP Signaling in Endothelial Heterogeneity BMPR2 SMAD6 SMAD4 PMC4984662__F8 Bunyavirus-induced Wnt/Beta-catenin signaling BCL9 APC GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC4729952__F3 Peroxisomes, fatty acid beta-oxidation and the human deficiencies of peroxisomal beta-oxidation PTH2 DBP ACOX1 LBP PMC3193402__F2 Crosstalk between RANKL- and TNF-induced NFKB signaling in OCs RELB TRAF3 TNF PMC5798385__F7 Proposed model for regulation of S6 phosphorylation (P) by the cAMP/PKA pathway RHEB MLST8 TSC2 TSC1 DEPTOR PMC8463593__F10 BAFF is involved in B cell differentiation and activation through the NFKB signaling pathway in RA CRP CD27 CD19 PMC3193402__F1 Classical and alternative NFKB pathways in skeletal cells RELB TNF PMC5411693__F6 Hypothesized altered feedback control of the POMC gene promoter in cells having USP8 or RASD1 mutations (mut) versus wild type (wt) RASD1 EGFR CRH POMC PMC8712487__F2 Myosin 1g and 1f: A Prospective Analysis in NK Cell Functions MYO1F ISG15 MYO1G PMC4459616__F3 Effect of sclerostin inhibition on Wnt signaling.Notes: Sclerostin is secreted by the osteocyte GSK3B LRP5 LRP6 TEF CTNNB1 PMC8667691__F1 Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer RAN DGCR8 AGO2 DBR1 DROSHA PMC4459616__F1 Wnt signaling pathways and the biology of sclerostin.Notes: (A) Canonical Wnt signaling: in the absence of sclerostin, Wnt binds to LRP 5/6 and its co-receptor, frizzled GSK3B LRP5 LRP6 CTNNB1 PMC9061994__F4 ROS-Influenced Regulatory Cross-Talk With Wnt Signaling Pathway During Perinatal Development APC GSK3B CTNNB1 PMC8483823__F4 Profile analysis of circular RNAs in cervical cancer MAX TH EPX FAS CD14 DAO PMC3000367__F5 Scalable Approach for Discovering Conserved Active Subnetworks across Species GNG4 PLK2 C3AR1 MYBL2 SOX2 PTPRC FOXF2 PAX6 GHRHR ZIC1 CD47 ZIC3 FGF7A RARB TUB FCER1G CD93 SIRPA CCNB1 LCK PMC9114355__F1 Adipose Tissue Derived Exosomes in Metabolic Disease CD81 CD9 CD63 PMC5620210__F2 ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway CDC42 FYN APC GSK3B MTOR SRC CTNNB1 PMC7432514__F3 Human diseases linked to eIF2 Ser-51 phosphorylation stress responses and the mTORC1 signaling pathway RHEB TSC1 ELF2 ATF4 MTOR PMC7875453__F2 BCR signaling pathways SYK ID2 CD72 CD22 BLNK TRAF6 BTK BCL10 BCR PLCG2 NFKB1 RELA SRC TRAF2 PMC12154905__F3 Scheme of the identified TNF signaling pathway, with genes identified by changes in mRNA levels in NS1-treated human lung microvascular endothelial cells (HLMVECs) compared to untreated control cells TH CD2 MMP14 FAS CAD TNFAIP3 SELE ITCH MLKL LIF IRF1 IL6 TRAF3 TNF PAX2 NOD2 CASP3 MMP3 TRAF1 TRAF2 CYLD FADD PMC8266488__F3 Sex Hormones and Gender in the Gut Microbiota TF SP1 SRC PMC5777791__F9 Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer BAX SKP2 CCND1 PMC6772763__F8 Multiple signaling pathways regulate the cell death pathway in sympathetic neurons BAX NGF JUN PMC7407234__F6 Proposed model for MX1’s role in ERS-mediated cell fate MX1 ATF4 XBP1 PMC11702355__F2 Classical and non-classical Wnt signaling pathways MMP7 APC WNT1 MYC CCND1 CTNNB1 PMC7975969__F3 Suppression effect of starvation in anorexia nervosa on mTOR system and end organ results RHEB MTOR DEPTOR IRS1 PMC7975969__F2 Nutrient effects in activation of mTOR system and the end-organ results RHEB MTOR DEPTOR IRS1 PMC8871376__F1 Adenylosuccinate lyase (ADSL) in de novo purine synthesis (DNPS) and the purine nucleotide cycle PAICS PNP ADK HEL-S-70p PFAS GMPR ADSL ADA PMC6459027__F1 Thiamine metabolism HEL107 TPK1 DKFZp667O1614 THTPA PMC10990754__F1 Various intracellular signaling molecules and pathways involved in HSCR PSPN GDNF ARTN NRTN IHH GFRAL SOX10 PHOX2B PROKR1 KIFBP NRG1 SEMA3C SEMA3D NTF3 PROK2 SHH ZEB2 RET PMC4962366__F8 Gene network ASIP MC3R MC2R AgRP KNG1 PMC8810962__F4 Estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet GABRA3 GABRG2 GABRB1 GABRA2 GABRB2 SLC6A11 UBQLN1 SLC32A1 GABRB3 GABRA4 GABRQ PMC10990754__F3 NcRNAs related to cell apoptosis, proliferation, migration, and differentiation in HSCR DCX E2F3 PLCB1 SRGAP1 PTEN GFRA4 RET PMC4281037__F4A IL-23-IL-17 immune axis: Discovery, Mechanistic Understanding, and Clinical Testing USP25 TRAF4 IL17RC TBK1 TAB3 GSK3B TRAF5 TRAF3 TRAF6 TRAF2 PMC5545069__F2 Iron Overload and Altered Iron Metabolism in Ovarian Cancer STEAP3 PCBP1 PMC9283756__F2 Circadian Rhythms Coordinated With Gut Microbiota Partially Account for Individual Differences in Hepatitis B-Related Cirrhosis CRP KLF15 CYP7A1 ARX PMC7648632__F1 PD-L1 degradation pathway and immunotherapy for cancer CDK6 SPOP EGFR GSK3B ATM CMTM6 TCF4 CMTM4 CDK4 CTNNB1 PMC8834120__F3 Landscape of PDK1 in Breast Cancer RHEB TSC2 BAD EGR1 MDM2 PMC11947053__F2 Research progress and prospect of MAPK signaling pathway in knee osteoarthritis JUN ETS2 OSM TRAF6 MYC TNF TRAF2 RAC1 FOS PMC8834120__F4 Landscape of PDK1 in Breast Cancer RHEB TSC2 AMIGO2 ARHA GRB2 PMC9384889__F8 Molecular Mechanism of Xingnao Kaiqiao Pill for Perioperative Neurocognitive Disorder and Its Correlation With Immune and Inflammatory Signaling Pathways Based on Network Pharmacology and Molecular Docking LCN2 REL PMC7971348__F2 Ubiquitin-proteasome pathway influences proteostasis, the cell cycle, and filamentation CYR61 CDC20 APC SKP1 PMC9384889__F7 Molecular Mechanism of Xingnao Kaiqiao Pill for Perioperative Neurocognitive Disorder and Its Correlation With Immune and Inflammatory Signaling Pathways Based on Network Pharmacology and Molecular Docking CA12 ITCH MLKL JUNB NOD2 TNF TRAF2 FADD PMC7648632__F2 PD-L1 degradation pathway and immunotherapy for cancer EGF ADAM17 EGFR GSK3B PC CMTM6 ADAM10 B3GNT3 PMC7071987__F1 Fundamental knowledge on IL-17 biology IL17RC EBP CXCL5 CXCL1 IL17RB TRAF6 CCL2 TNF TRAF2 PMC1805736__F6 Pathways for synthesis of adrenal steroids CYP17A1 CYP11B2 CYP11A1 PMC3640439__F1 Induction and evasion of type I interferon responses by influenza viruses MAVS TLR3 TLR8 IRF3 TLR7 MYD88 PMC4706689__F2 IL-10 Anti-inflammatory Signaling Pathway is enriched for putative differentially expressed genes (Progressors vs NonProgressors Enrichment False Discovery Rate adjusted P-value = 0.0287) Figure is a stylized representation of the Biocarta pathway STAT5B HEL-S-10 STAT4 IL10RA TNF PMC9097893__F2 NLRX1 Deficiency Alters the Gut Microbiome and Is Further Exacerbated by Adherence to a Gluten-Free Diet TH NLRP1 CXCL12 NLRX1 NLRP7 RELB IL33 TRAF3 TNF TRAF2 PMC8921673__F1 Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration ABO GSK3B IRS1 PMC10454639__F11 Regulatory pathway map of roots suffering Mn poisoning in soybean CAST FER PMC4706689__F1 IL-10 and integrin signaling pathways are associated with head and neck cancer progression THBS1 COMP ITGA7 VTN ITGB3 HEL-S-78p ITGAX JAM3 ITGA2B ITGAV SPP1 ITGAM AGRN COL18A1 ITGB8 FGA ITGB5 PMC5638382__F1 Different endothelial responses to different patterns of flow KLF4 KLF2 EGR1 ATF2 ARHA PMC6893739__F2 Merlin signaling LATS1 CD44 LATS2 PAK1 MTOR RAC1 PMC7559019__F4 Various factors influence the occurrence of liver cancer HRAS PC PTEN NF2 PMC8921673__F2 Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration PDE3B GSK3B APP GRB2 SHE TBC1D4 PMC7848033__F1 Role of Osteocytes in Modifying Bone Matrix Properties SOST COL1A1 DMP1 CTSK PTH PMC7925099__F15 The action of PAV-206, a possible first-in-class selective inhibitor of HIV-1 assembly XRN1 PMC3265866__F7 PGC-1Alpha- and AMPK-mediated regulation of IL1Rn expression in hepatocytes CRP NR1C1 IL1RN IL1B PMC5889282__F7 BGN- and DCN-mediated inhibition of the TGFB pathway and restriction of HER-2/neu signaling TGFBR2 EGFR DCN TGFBR1 PMC9532189__F1 Serum Homocysteine and Vascular Calcification: Advances in Mechanisms, Related Diseases, and Nutrition MGP GPX1 PMC8699554__F4 COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging Association, Therapeutic Options and Challenges TH CD48 TREM2 FOLR2 FCN1 ID2 FABP4 S100A12 IL1B SPP1 PMC7072680__F1 gp130 cytokines and receptors activate downstream signaling pathways CNTFR CNTF OSM OSMR EBI3 LIF PMC8699554__F1 COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging Association, Therapeutic Options and Challenges CRP IFNG APC PMC7299830__F3 Eribulin combined with irinotecan inhibits DNA replication and induces TP53 pathway genes GML CD40 BAX FAS PCNA STAG1 PERP GSK3B PML JMY PTEN HIF1A ATF2 TNF CTNNB1 MDM4 WT1 BRCA1 BCR PIAS1 HDAC9 SCO2 MDM2 PMC420513__F4 Immune synapse_related signaling pathway and autoimmune diseases SLC22A4 CD80 CD2 PLCG1 FYN PDCD1 RUNX1 CBFB LAT LCK NAT9 PMC7757038__F1 Exosome biogenesis and composition CD81 RAB27A RAI1 RAB27B CD9 CD82 ARF6 TSG101 RAB35 CD63 PMC5694456__F9 Schematic illustration revealing the anti-inflammatory effects of gApN on microglia ADIPOR1 TNF IL1B PMC3881972__F1 Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals: a review of recent research TIRAP CD36 CD14 TLR5 IRF3 TRAF3 TRAF6 MYD88 TLR3 COX2 TLR4 NOD2 NOD1 CARD9 PMC4987160__F4 Genomic Landscape of Male Breast Cancers TES MUTYH FANCA PMC5932347__F1 RIG-I-like receptors and toll-like receptor (TLR) 3 signaling pathway TBK1 MAVS TANK IRF3 IRF7 TRAF3 TRAF6 PMC3048839__F10 Schematic representation of IH-induced increase in adrenal medullary NPY by activation of reactive oxygen species (ROS) signaling pathway CTSL PMC7828553__F2 FGFR signaling pathway FRS2 GRB2 PMC4384349__F5 Schematic presentation of VEGFR-1 activation in CC tissue and its association with metastasis VEGFB PIGF VEGFA PMC12111897__F6 Signal transduction pathways for the Al+ADAl3–4 vs TF MKS1 BIN2 EBF2 BAK1 PMC3592471__F8 Functionally related pathways of aberrantly methylated and differentially expressed genes in immortalized MEFs TM4SF13 MAPK11 MED9 SP1 SOSTDC1 PHOX2A REM2 CP PMC7819155__F2 Roles of the lncRNA H19 in osteogenic differentiation RUNX2 CTNNB1 PMC12120737__F5 PCSK9 activated the EGFR/HER3 signaling pathway in TNBC cells PCSK9 CCND3 HEL-S-162eP EGFR LDLR SRC PMC9395634__F4 MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes RPS16 BAMBI ADIP MT2A TAC3 RGS5 PAX8 RIDA CRIM1 TNF TCIM PMC5386953__F2 Signaling Pathways Controlling Microglia Chemotaxis VASP CD36 SRC PMC9395634__F3 MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes ADAMTS15 ADAMTS14 IFRD1 CRTAP ADAMTS2 COL5A2 DST AF1Q TRMT1 PMC3848550__F2 Schematic representation of the sialic acid metabolism pathway in eukaryotic cells NEU2 NEU4 GAL NEU3 ST6GAL1 NEU1 PMC8509620__F8 Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway LPA ROCK2 CDK2 CCNA2 LPAR1 CCND1 CDK4 PMC7797432__F2 SFRP-2 in the Wnt/Beta-catenin signalling pathway in cancer APC GSK3B BRAF CTNNB1 PMC5993148__F3 SLC7A11 regulates nutrient dependency of cancer cells SLC3A2 GLS SLC7A11 PMC3013243__F9 Myeloid-specific GPCR kinase-2 negatively regulates NFKB1p105-ERK pathway and limits endotoxemic shock in mice ADRBK1 TLR4 IL1B PMC11240502__F2 Tryptophan metabolites interact with AhR and potentially interfere with serotonin and melatonin synthesis CYP1A2 AANAT AHR ASMT CYP1B1 CYP1A1 PMC11240502__F1 Effects of UVA and UVB radiation on skin tryptophan lead to pro-inflammatory pathways COX2 EGFR AHR PMC3291637__F2 Proposed differences in the localization of Fe-S cluster biogenesis proteins in S NUBP1 NFU1 ISCU ABCB7 CIAO1 NDOR1 PMC8347979__F4 ADAM 17 and Epithelial-to-Mesenchymal Transition: The Evolving Story and Its Link to Fibrosis and Cancer ADAM17 MMP2 MMP9 SRC PMC3291637__F1 General scheme for biogenesis of Fe-S clusters in mammalian cells NFU1 ISCU BOLA3 NUBPL FES PMC8909058__F4 Relevance of Aquaporins for Gamete Function and Cryopreservation AQP3 AQP7 AQP9 PC HP AQP8 AQP11 PMC10245950__F12 Glycolysis in cardiomyocytes is upregulated in the oxaliplatin treated mice ENO2 HEL-S-133P HK3 HK2 LDHB HEL-S-30 PGAM1 PGAM2 ALDOB ENO3 FBP2 HEL-S-68p HEL-S-162eP ENO1 GCK HEL-S-87p PMC10245950__F13 Effect of oxaliplatin on NAD+ and NADP+ synthesis and salvage pathways ENPP3 ENPP4 NUDT12 NMNAT1 SIRT4 BST1 NAMPT SIRT2 ENPP1 SIRT3 ENPP6 PNP SLC25A51 NADK ENPP2 SIRT1 NNT NMNAT3 PMC10474743__F4 Advances in immunotherapy for triple-negative breast cancer CGAS MUC1 CTLA4 PMC5992481__F1 miR-24 and miR-122 Negatively Regulate the Transforming Growth FactorB/Smad Signaling Pathway in Skeletal Muscle Fibrosis TGFBR2 SMAD2 SMAD4 TGFBR1 PMC3856112__F7 Combination of pathway topology and ab initio reconstructed network HEL113 CSRP2 HEL-S-273 IGFBP2 RABEPK UBE4A GYG1 HSPB7 KCTD10 HPD MYL6 TBX1 SP110 MDC1 SST KCNK3 SEC31A PTMAP7 ESRP2 DHX29 FGL2 LAMA4 PSPH AATF PS1TP5BP1 PMC5992481__F5 miR-24 and miR-122 Negatively Regulate the Transforming Growth FactorB/Smad Signaling Pathway in Skeletal Muscle Fibrosis TGFBR2 SMAD2 SMAD4 TGFBR1 PMC4114960__F4 Viral-Induced Rewiring of Host Metabolism Leads to an Increase in Fatty Acid Biosynthesis PHGDH HEL-S-162eP PSPH PMC6165581__F2 Illustration of miRNA biogenesis pathway and mode of gene regulation RAN DGCR8 AGO2 DROSHA PMC5490158__F4 Upstream regulators identified by Ingenuity Pathway Analysis, predicted to participate in the regulation of gene expression upon A2B-adrenoceptor activation in A7r5A2B vascular smooth muscle cells CX3CL1 AHR CCL2 NPPB PMC9158472__F6 NFE2L3 as a Novel Biomarker Associated With IL-2/STAT5/NLRP3 Signaling Pathway in Malignant Pleural Mesothelioma and Other Cancers IL10 NLRP3 IL13 IL4 IL5 NFE2L3 PMC7604315__F2 Neddylation and HCC NEDD8 SAG VHL PMC5873813__F2 Broad overview of the genetic architecture of inflammatory bowel disease giving examples of confirmed and candidate genes implicated in each pathway STAT3 ICOSLG MTMR3 ATG16L1 LRRK2 FUT2 IL27 IRGM CAPN10 XBP1 TNFRSF6B TAGAP ORMDL3 TLR4 CCR6 NOD2 IL23R TYK2 PMC3457296__F8 LMP2A induces signaling pathways that promote membrane localization of AV-integrin and epithelial migration SYK GSK3B SRC PMC5977110__F5 Pathways that influence YAP and TAZ in lung cancer LATS1 LPA EGF LATS2 RASSF1 ABL2 EGFR CTNNB1 PMC4817727__F3 Role of axin in Wnt signaling in bone APC LRP5 LRP6 CTNNB1 PMC4817727__F4 Role of RGS proteins in selected GPCR signaling in bone CASR RGS2 RGS12 RGS18 RGS5 RGS10 NFATC1 PTH1R PMC5977110__F1 Hippo pathway core components and their upstream regulators LATS1 LPA LATS2 RHO CTNNB1 PMC5977110__F2 Main proteins and pathways that influence YAP and TAZ in lung development and tumorigenesis LATS1 LPA EGF LATS2 RASSF1 ABL2 CRB3 EGFR AMOT PMC5585663__F1 The Nrf2/Keap1/ARE pathway in type II diabetes mellitus KEAP1 NQO1 HEL-S-44 PMC3873541__F7 Enriched canonical pathways of miRNA target genes FLT3 STAT3 BAD RAF1 SHC1 PXN IGF1R SOCS3 MAP2 MAPK8 MEF2C RARA GRB10 CASP9 NOS2 JUN PTPN11 ARG1 FOS IRS1 MNDA RUNX1 IGF1 NEDD4 JAK1 MAP2K1 GRB2 PMC9181071__F1 Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway TG EGF MTOR HDAC2 MYD88 PMC6973314__F11 Role of BST2, E-cadherin, and signaling pathways in IFN-Gamma-mediated decrease in invasion of HTR-8/SVneo cells STAT1 PMC10245950__F10 TCA cycle is affected by oxaliplatin SDHA SUCLG1 SUCLA2 ACO2 IDH3B OGDH SUCLG2 CS MPC1 MDH2 MPC2 PMC10706216__F16 Activation of UPR signaling pathways during ER-stress, caused by TAA injections, in liver cells BAX ATF4 TRAF2 PMC6131589__F1 Sights and mechanisms of mHTT toxicity in yeast models of HD HEL-S-62p KMO HTT PMC2894449__F1 Stages of apoptotic cell engulfment and associated cell signaling events that regulate each stage LAMP2 ARHG CD36 CD14 CR1 PMC8926903__F1 Genomic and transcriptomic landscapes of clock genes reveal the significance of circadian rhythm in the progression and immune microenvironment of metastatic colorectal cancer PER3 NPAS2 RORC AIPL1 PER1 NR1D1 CRY2 CRY1 NR1D2 RORB PMC4813390__F3 Influence of TGFB‐SMAD and TGFB‐TAK1 signalling on adrenoceptor‐mediated pathways in LV heart failure progression TGFBR2 TGFBR1 PMC3474280__F1 Central position of the locus coeruleus in relation to the acoustic startle reflex and pupillary light reflex pathways LAT CS RET PMC5693031__F7 Tight junction pathway overrepresented among Qki5 HITS-CLIP target genes based on DAVID-KEGG pathway analysis CDC42 RAB3B PATJ RAB13 ERBB2 PTEN CASK PALS1 RHO CDK4 CTNNB1 PMC4693890__F3 Cytokine signalling networks in women with chlamdyial infections (a) or gonorrhoea (b) were evaluated using Ingenuity Pathway Analysis LTB CCL11 CCL4 PMC6678762__F6 Schematic diagram illustrating the proposed SIRT1 signaling pathway involved in PGC1A/mitochondrial biogenesis that exerted an endogenous protective mechanism in the hippocampal neuronal tissue following experimental status epilepticus TFAM NRF1 SIRT1 PMC11897032__F1 Pathways of serine synthesis and metabolism PHGDH SHMT1 HEL-S-51e PMC5343774__F2 Summary of cross-talk between cancer cells and the tumour microenvironment mediated through the 5-lipoxygenase pathway LTC4S KPG_011 PMC8207819__F1 Regulated cell death pathways at a glance SLC3A2 TBK1 FAS TRADD GPX4 MLKL OTULIN TANK FACL4 SLC7A11 POR SHARPIN GSDMD NLRP3 ZBP1 RIPK1 APAF1 CYLD BAX CASP8 CYB5R1 TSG101 RIPK3 HMGCR CDC37 FADD PMC5343774__F3 Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway FOXP3 IL1B PMC4917709__F2 Negative modulation of EMT by sirtuins MMP7 SIRT4 SMAD4 SIRT2 CTNNB1 PMC6884928__F2 Phosphatidylinositol 3-kinase (PI3K)/pAkt-kinase pathway as a central CCL5/CCR5 signalling cascade in cancer cells CCR5 PTEN SRC PMC2781509__F1 Folate-mediated one-carbon metabolism SHMT1 PMC6651563__F1 G protein-coupled receptor (GPCR) signaling GSK3B RHO DISC1 PMC8238141__F7 Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells RB1 LONP1 RICTOR KDM5A PMC5581716__F2 The ferroptosis pathway and the inducers and inhibitors of ferroptosis SLC3A2 TRO GPX4 CPO SLC7A11 PMC7143295__F2 Canonical Wnt Pathway and Inhibitors of the Wnt/beta-Catenin Signaling Pathway schematic representation of the Canonical Wnt Pathway and pharmacologic inhibitors of the Wnt/beta-catenin signaling pathway GK3 PC TNIK CTNNB1 PMC9347991__F1 Comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID‐19 patients by phytotherapeutic melatonin and epigallocatechin‐3‐gallate TNF ACE2 PMC9347991__F3 Comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID‐19 patients by phytotherapeutic melatonin and epigallocatechin‐3‐gallate HMGB1 NLRP3 TLR4 SIRT1 IL1B PMC9376458__F5 Transcriptome Analysis of Dendrobine Biosynthesis in Trichoderma longibrachiatum MD33 GGPS1 HMGCR DHDDS MVD FDPS MVK PMC9347991__F2 Comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID‐19 patients by phytotherapeutic melatonin and epigallocatechin‐3‐gallate BAX NLRP3 TLR4 ACE2 SIRT1 PMC12139089__F5 Hippo signalling contributes to renal fibrosis and damage in diabetic conditions LATS1 SMAD1 LATS2 SMAD4 MB PMC2974775__F4 Ca2+ waves activate transcription factor NFAT that in turn controls cell cycle ORAI1 STIM1 MYC PMC3676649__F2 Musashi signaling pathways associated with mammary progenitor cell expansion DKK3 MSI1 GSK3B LRP5 JAG2 NUMB LRP6 MYC CCND1 NOTCH1 CTNNB1 PMC5041099__F3 Integrative transcriptomic meta-analysis of Parkinson’s disease and depression identifies NAMPT as a potential blood biomarker for de novo Parkinson’s disease CLEC7A CXCL5 NMB TNFRSF25 HLX SLC22A4 MAN2C1 PATL2 CEACAM21 IER2 ADORA2B IL18RAP ZFP36 SRGN CASP8 SIN3A FOSB IL18R1 JUNB LIMK1 NAMPT FOS MNDA TIEG2 TCF7L2 IL8RB EGR2 FAS BCL2A1 RASSF4 pp6425 CTNNB1 IL1R2 IL1R1 QPCT FOXN2 IFITM3 IL18 DPP4 RLN1 HEL-S-15 CFL2 MGRN1 TNLG1B EGR1 GNB5 MYO6 LPAR1 GCG AQP9 NFKB1 SSH1 STAP1 LILRA5 S100A12 TNFSF10 FADD ADA PMC6690608__F1 Metabolic reprogramming in CRC GLS COX2 PHGDH FASN PMC8235403__F14 Orthosiphon stamineus Proteins Alleviate Hydrogen Peroxide Stress in SH-SY5Y Cells FKBP4 PTGES HP PMC5328835__F1 Role and mechanism of action of Sclerostin in bone LRP4 SOST LRP5 LRP6 PTH TNF CTNNB1 PMC12139089__F3 Activation of transforming growth factor 1 (TGFB1) signalling in the development of DKD STAT3 TGFBI SMAD2 SMAD4 MTOR PMC6499508__F6 Graphical summary CD36 FASN CCR2 SREBF2 NR1C2 TNF ABCA1 GATA3 PCSK9 UCP2 TNFSF14 IFNG TG ABCG1 HMGCR TLR4 IL18 LDLR PC APOB BOK IL8RB PMC3945336__F1 Mannose and glucose metabolic pathway PMC7202519__F7 Our hypothesis that exercise training suppressed inflammatory and apoptotic pathways and enhanced IGF1R/PI3K/Akt survival and anti-aging AMPK/SIRT1/PGC-1A associated pathways in the hippocampus of D-galactose induced aging rats FAS COX2 IGF1R SIRT1 FADD PMC5595348__F11 HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection MAP3K7IP1 IRF3 TLR7 TRAF3 TRAF6 EEA1 IFNA1 IL1B MYD88 PMC8627624__F1 Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation PI3 PTEN LYN PMC3841320__F4 Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells DUSP5 GNA15 IFNG THBS1 EGR1 ETS2 PRDM1 FGFR3 CCL20 LAMA3 SFRP1 HOXA5 PMC11058197__F6 Proposed model of the Notch-ROCK pathway and its biological significance NOS2 TLR4 JAG2 HES1 NOTCH1 PMC3927127__F2 Cytokine-induced differentiation of human B cells in vitro: requirement for IL-21 signaling in vivo CD40 STAT3 CD80 IL10 BCR JAK3 IL21R PMC6562797__F6 Flaccidoxide-13-acetate-induced apoptotic pathway in bladder cancer cells BAX BAD ATF4 EIF2A H1-1 PMC4131533__F8 Interaction network of differentially expressed miRNAs and their targets: network construction can be divided into two components: miRNA-target and target-target interaction, and candidate miRNA targets were predicted by mRDB SMAD9 ACVR2A SMAD2 SMAD4 PPP2CA PITX2 TGFBR1 TGFBR2 RBL1 IFNG INHBB INHBE FST RPS6KB1 NOG ID4 BMP2 SMURF2 PMC3714205__F2 Signaling via by cytokines and growth factors and its negative regulation by SOCS proteins SOCS1 SOCS7 SOCS4 SOCS5 SOCS2 SOCS3 PMC6946658__F1 Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy AMD1 SLC3A2 SMS SMOX PAOX PMC8870127__F1 Bright and the Dark Side of TGFB Signaling in Hepatocellular Carcinoma: Mechanisms, Dysregulation, and Therapeutic Implications SMAD2 SMAD6 SMAD4 TGFBR1 PMC1949901__F1 Current understanding of the pathways of fatty acid synthesis which are known to occur within the Brassicaceae FAS HEL-S-62p PC PMC7817624__F1 Metabolic pathways in breast cancer cells ACLY GLS HEL-S-133P FASN HIF1A MTOR HEL-S-30 MYC PMC7566085__F4 Identifying Drug Sensitivity Subnetworks with NETPHIX RB1 MDM4 BTK BCR EGFR ERBB2 ATM MDM2 MYC VILL PMC5858971__F2 Targeting the IL-6/JAK/STAT3 signalling axis in cancer SOCS1 STAT3 PDLIM2 PTPN1 SOCS3 SRC PMC7248678__F2 Routes of pDC sensing CGAS DHX36 TLR9 IRF3 IRF7 TLR7 MYD88 PMC5858971__F1 IL-6 signalling pathways STAT3 ADAM17 ADAM10 PMC9389045__F6 Identification of Potential Ferroptosis Key Genes in the Pathogenesis of Lumbosacral Spinal Root Avulsion by RNA Sequencing and Bioinformatics Analysis PDHA1 TIMP1 RALA HEL-S-133P HEL-S-162eP AMT CREBBP EPO BCL2 PMC8304605__F1 Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease SUFU PTCH1 IGFL1 GSK3B BCL2 SMO PMC6820656__F5 Ovarian cancer pathway enriched by target genes of the identified miRNA biomarkers in IPA DVL1 EGF EGFR PTEN MMP9 FSHR RB1 COX2 FGF9 MMP2 SRC MTR CDK4 PMC8304605__F3 Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease TCF4 KRAS CTNNB1 PMC8692171__F1 PTEN-PI3K-AKT-mTOR pathway and therapeutic targets RHEB TSC2 PKD1 TSC1 SGK1 PTEN PMC4366240__F7 Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53 ACLY SCD FASN MTOR PMC4366240__F4 Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53 EMP2 BAX DYRK2 TRIAP1 EWSR1 PCNA PRKRA PRNP MCRS1 SNCAIP SLK MAPK3 GNAS MON2 NOP2 NME2 WWOX HSPA4 CSNK1A1 MDM2 HNRNPK GPS2 YWHAZ TRIM23 PMC3570128__F2 Wnt signaling affects c-Myb stability and activity FBXW7 HIPK2 NLK PMC3588076__F3 Regulatory networks of mTOR inhibitors and miRNAs in controlling the mTOR pathway in cancer TSC2 TSC1 ULK1 PTEN IGF1R ELF3 EIF4E PMC3588076__F2 mTOR signalling pathway RHEB MLST8 TSC2 RICTOR TSC1 ULK1 PTEN MTOR DEPTOR EIF4E PMC2760340__F2 Representation of NF1 interactions with the Ras and PI3K pathways NF1 PTEN GRB2 MTOR PMC6168666__F3 CARD14/CARMA2 variants in keratinocytes BCL10 RNF7 DEPDC7 TRAF6 ULK2 TRAF2 PMC11883231__F7 Proposed biosynthetic pathway of polyphyllins in P SSR1 SSR3 SSR2 PMC6567317__F2 Known mechanisms and signaling pathways involved in histone deacetylase inhibitor-activated induction or suppression of autophagy CASP9 MDM2 MTOR PMC6589502__F2 Generalized Lymphatic Anomaly and Gorham–Stout Disease: Overview and Recent Insights EPHB4 EFNB2 PIK3CA VEGFC PI3 GLA MTOR PMC5130266__F10 Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling SMAD2 HDAC5 PMC10484181__F3 Potential mechanism of P2X7R overexpression causing tumor progression COX2 ARG1 NFATC1 PMC101242__F7 Up-regulation of RAD51 in 8-MOP-treated cells RAD52 RAD50 RAD51 PMC9359065__F1 PERK promotes immunosuppressive M2 macrophage phenotype by metabolic reprogramming and epigenetic modifications through the PERK-ATF4-PSAT1 axis PHGDH IL4 PSAT1 ATF4 PMC4058660__F2 PI3K signaling in neural aging and disease GSK3B MTOR PMC3136910__F2 Proposed model of ATF2 regulation of Ha-Ras signaling TPR ATF2 REL PMC9165365__F3 “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders FAS MCU PMC3970925__F1 Activation of PPRs in cardiomyocytes by DAMPs during myocardial I/R injury HMGB1 TLR4 TLR9 PMC3997674__F2 Signaling pathway of TRAIL/drug combinations STAT3 BAX SP1 PMC4817553__F1 The Hedgehog signalling pathway in Drosophila and vertebrates KIF7 SUFU SMO PMC3997674__F1 Dual opposing signaling pathways of TRAIL BCL2 TRAF2 FADD PMC8705692__F1 Cardiac Changes in Parkinson’s Disease: Lessons from Clinical and Experimental Evidence TH NTS PNMT DBH PMC3470479__F1 The Genetics of Alcohol Dependence: Advancing Towards Systems-based Approaches HEL-S-117 ALDH2 CYP2E1 PMC3164695__F7 The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO IGFBP1 GADD45A SIRT1 PMC8555307__F4 Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma TIRAP TLR9 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 TLR10 FADD PMC7053243__F9 Schematic diagram showing the proposed mechanism of MYC inhibition by excess BASP1 protein competing for binding to CaM MAX BASP1 MYC PMC3672537__F2 Postulated interaction between the insulin signaling pathway and activation of the pro-inflammatory cascade in the pathogenesis of insulin resistance in sepsis TLR4 CD14 TNF LBP IRS1 PMC6647379__F3 Tumor microenvironment influences the metabolic status of cancer cells with consequences for their metastatic potential FAS HMGCR CD36 LDLR CA9 PMC8835992__F7 Thyroid Hormone Receptor A Controls the Hind Limb Metamorphosis by Regulating Cell Proliferation and Wnt Signaling Pathways in Xenopus tropicalis CDC2 CDK6 CDK2 CDK4 PMC6912706__F2 SGA-induced impairment in hepatic insulin signaling and glucose metabolism FOXO1 IRS1 PMC7003246__F2 Targeting the CD47-SIRPA pathway in cancer SIRPA CD47 PMC8213534__F1 TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review MAP3K7IP1 TRADD TLR3 IRF3 IRF7 TRAF3 PMC2945462__F1 Complement cascade is comprised of the Classical, Alternative, and Mannose Binding Lectin pathways C6 C7 C2 C1S CS C4A PMC6854696__F5 Schematic diagram of miR-889 regulates osteoblastic differentiation of hBMMSCs by targeting WNT7A and through Wnt Beta-catenin signaling pathway LRP5 WNT7A LRP6 CTNNB1 PMC7854845__F2 UPF1 Activation in the Two Major NMD Branches UPF2 SMG1 SMG9 SMG8 UPF3B DHX34 PMC8835992__F8 Thyroid Hormone Receptor A Controls the Hind Limb Metamorphosis by Regulating Cell Proliferation and Wnt Signaling Pathways in Xenopus tropicalis BARX2 SMYD2 CARF SOX11 FOXK1 EGFR DLL4 GSK3B FHL2 NRARP LRRFIP2 TERT TCF4 CTNNB1 FOXM1 RBX1 GRIP1 SHH RUVBL2 SOX4 HMGB2 TDG PMC2660918__F2 Hypothetical model for the end-joining mechanisms during CSR ATR RAD50 MSH2 MRE11A WRN ATM UNG PARP1 PMC2481274__F2 Type I Interferon: Potential Therapeutic Target for Psoriasis? STAT1 STAT2 IRF2 PML IRF1 IFIT2 TYK2 PMC6034319__F3 Cross-talk between tumor, MDSCs and immune cells for development of HPV-related carcinogenesis CXCL12 EGF CCL5 CCL2 CXCR4 PMC8213534__F2 TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review MAVS TLR3 TICAM1 PMC8928433__F7 Polysaccharide From Eupolyphaga sinensis Walker With Anti-HBV Activities In Vitro and In Vivo NR2A1 TLR4 IRF3 MYD88 PMC3268188__F2 Tumour suppressor p53 regulation and signalling HTRA2 BAX ATR FAS ATM RRM2B MDM2 PMC8618298__F4 Current Status of Photodynamic Diagnosis for Gastric Tumors HMBS CPOX ABCB6 ABCG2 FECH UROD UROS PMC8209385__F5 Identification of Methylation-Regulated Differentially Expressed Genes and Related Pathways in Hepatocellular Carcinoma: A Study Based on TCGA Database and Bioinformatics Analysis OXT KLF4 SFRP5 HTR7 IFITM1 MTOR IRF4 CR1 HBA2 TBX21 GATA3 CCNE2 FZD8 GSTM1 SNAI1 ID4 GNB4 MAF MMP2 THBD MLF1 PTGER4 PMC7331465__F1 IL-7R Signaling Drives Proliferation and Survival while Preventing Premature Igk Recombination Programs During B Cell Development in Mice CCND3 BRWD1 BAD FOXO1 MCL1 BCL2 IL7R RAG2 RAG1 MTOR MYC PMC6545067__F6 Graphic conclusion HMGA2 CCND1 CTNNB1 PMC8039208__F4 Effects of circRNAs on the Warburg effect-associated signaling pathways STAT3 HEL-S-133P HEL-S-68p HK2 HEL-S-162eP FLOT2 ENO1 PMC11898978__F2 Tissue fragmentation and mechanical manipulation disrupt the ovarian Hippo signaling pathway, promoting follicle growth LATS1 LATS2 PMC8909324__F12 Biglycan Interacts with Type I Insulin-like Receptor (IGF-IR) Signaling Pathway to Regulate Osteosarcoma Cell Growth and Response to Chemotherapy SUMO1 PTEN CS PMC11898978__F1 PI3K/AKT signaling pathway is a key regulator of primordial follicle activation RPS6 TSC2 TSC1 KIT PTEN MTOR PMC11952802__F4 Periosteal microenvironment on P-SSCs POSTN NGF SFRP4 CD200 RUNX2 PMC10149907__F5 Regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer OGDH HEL-S-68p HEL-S-26 PMC7789501__F2 Protein–protein interactions for the differentially expressed proteins in ApoE−/−/LDLR−/− mice (vs SAA1 APOC3 HEL-S-130P GUGU F7 PROS1 APOB THBS4 CS VCAM1 SAA4 PZP PMC6484007__F1 STIL: a multi-function protein required for dopaminergic neural proliferation, protection, and regeneration SUFU SHH SMO STIL PMC4765526__F1 Cartilage matrix homeostasis is regulated dynamically by the TGFB signaling pathway SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC4066991__F1 Missing Link between Itch and Inflammation in Atopic Dermatitis TSLP TRPA1 ITCH STIM1 PMC6488142__F1 PI3K/Akt /mTOR pathway RPS6 TSC2 TSC1 PTEN MTOR PMC8483511__F3 Molecular pathways linking the CD137 signaling pathway to ECs TET2 BAX SMAD1 DKFZp781O1323 BCL2 NFATC1 PMC8740962__F1 Proposed simplified schematic representation of SARS-CoV-2 induced intracellular pro-inflammatory signalling pathway TIRAP TLR3 TLR4 TLR8 TLR7 TRAF6 MYD88 PMC9450808__F2 Hepatocellular carcinoma: Novel understandings and therapeutic strategies based on bile acids (Review) AKR1D1 CYP8B1 BAAT CYP7A1 ABCD3 HSD3B7 CYP7B1 CYP27A1 AKR1C4 PMC7393270__F6 Ingenuity Pathway Analysis (IPA) top regulator effect networks analysis of differentially expressed (DE) genes between Muc1−/− vs APOC2 APOA4 NR2A1 OSM FABP2 MUC2 FOXA2 HNF1A PMC2878081__F7 Schematic overview of the pyruvate/isocitrate cycle and OGC, important components of the pathway regulating glucose- and glutamine-stimulated insulin secretion GLUD1 CIC PC PMC3741284__F2 Hepatitis C Virus Induced miR200c Down Modulates FAP-1, a Negative Regulator of Src Signaling and Promotes Hepatic Fibrosis CDC42 TCF12 CLEC3A ITGA4 MAPK15 ITGB3 HRAS DAB1 SF1 ITGB1 NFIB SYNGR2 ADAM12 CREB1 RET BIK LCK PMC7407770__F4 Possible approaches for MASTL therapeutic targeting and the expected biological outcomes from each strategy ENSA ARPP19 MASTL PMC8589435__F3 Canonical Wnt signalling is critical for ISC niche maintenance and is potentiated by Lgr5 RNF43 APC LRP6 GPR49 PMC6039345__F6 Schematic diagram showing the role of Sulfatase-1 in inhibiting mesothelin expression in Carcinogenesis STAT3 MSLN PMC9343807__F1 Hippo–YAP/TAZ Signaling Pathway in Intestinal Self-Renewal and Regeneration After Injury LATS1 LATS2 NF2 PMC3014256__F3 A-Kinase Anchoring Proteins: Getting to the heart of the matter SIAH2 HDAC5 NFATC3 PMC6252330__F3 Regulators of glioma cancer stem-like quiescence in the niche CXCL12 EGF HGF CXCR4 PMC8555377__F3 High frequency of clonal hematopoiesis in Erdheim-Chester disease TET2 SF3B1 U2AF1 BRAF NRAS EZH2 MAP2K1 KRAS PMC6252330__F1 Molecular mechanisms underlying cell cycle by cancer stem-like cells CDC2 TSC2 CDK6 TSC1 CDK2 PTEN CDK3 HES1 CDK4 PMC7642714__F8 C-type lectin receptor signaling pathway TH SYK FRY RELB ARHA CYLD PMC10478443__F4 Functional enrichment analysis of IGF2BP1 regulated pathways in B-ALL WDR12 FLT3 RAN PIK3IP1 TNFRSF10B SYNJ1 CRMP1 CYCS NRP1 PLK1 RNP24 FLRT3 NFIL3 POP1 ERN1 CD109 HEL-S-99n HSPD1 PES1 PRXL2A RNASET2 CD9 MSR1 DDX39A MAP3K15 HEL-S-26 TOMM40 BNIP5 TIMM17A MST065 HEL-S-44 MAPK1 CTIF GOT2 SP1 SOX11 DKC1 MXD1 PTBP1 PRKX GNG7 TF NOL11 TGFB1 ACADSB NDUFA6 FADS2 FADS1 ABCA1 PRKCB PLEK SHANK3 PROX1 TFRC CCND2 PNO1 S1PR2 DHX15 POU4F1 RAG1 APP HEL-S-283 CEBPB HLA-DMB KLF6 PER1 RRM2 UTP20 ETF1 KRAS RPA1 HEL-S-34 PTPN22 CBL RUNX1 TIMM50 MAFF TLR3 RHOB SCAP2 SH2B3 TSR1 PTGER4 P4HA1 CPT1A STYX FUS CD40 COX7B RASSF2 CSF1 PSMD12 APOBEC3C KARS1 IRAK1 ABCF2 SENP3 HNRPR HEG1 BCL9 KDM6B UNG ACADVL HEL-S-1 TRIB3 FHIT HNRNPL PRPF19 HLA-DQA2 ALYREF IGF2BP1 ATF5 TP53INP1 HEL-S-133P CRKL SLC2A3 LGALS9 STARD4 ERG AF1Q BHLHB2 NUP62 ATF3 FOXO1 PLAG1 Nbla10317 DHCR7 AK4 GADD45A AKAP12 HEL-75 TET2 KLF2 TMEM97 COX10 DDIT4 SURF1 EDEM1 PSMA4 PSMB2 PSMA2 ADNP PSMD2 PSMD1 INSIG1 ISG20 PNP CD300A TNFRSF13C PPP1R15A WDR4 GAREM1 NENF ZDHHC9 CSTF2 KLF10 HEL2 BAX HMGB1 JUN CDKL5 AMBP PTBP3 LTV1 SP2 RHOT2 CKAP4 RAP2A AGER DCAF13 NAT10 HEL-S-69p BCAT1 PSAT1 MAP2K2 ASNS KLF13 PMC7642714__F9 IL-17 signaling pathway PTER TH COX2 FADD PMC5541421__F4 TREM2 signaling and function TREM2 SYK LTA APOE CCR7 PC CTNNB1 PMC3531240__F11 IFNA and LPS up-regulate APOBEC3 (A3) mRNA through different signaling pathways STAT1 TLR4 IRF3 MYD88 PMC5144739__F1 Interleukin-10 (IL-10) gene transcription regulation CD209 SYK TLR4 MYD88 PMC6443620__F3 Hypoxia-inducible factor-1 (HIF-1) signaling pathway EIF4B EPO PTEN MTOR VHL PMC5695831__F10 Schematic of pathways for transcriptional activation of Forkhead box protein O1 (FOXO1) and IGF-1 in the mouse liver IGF1 STAT5B FOXO1 IGFBP1 GHR PMC8234490__F8 Ergosta-7, 9 (11), 22-trien-3Beta-ol Interferes with LPS Docking to LBP, CD14, and TLR4/MD-2 Co-Receptors to Attenuate the NFKB Inflammatory Pathway In Vitro and Drosophila TIRAP TLR4 CD14 LBP IL1B MYD88 PMC3949135__F1 Schematic Ig synthesis pathway CXCL13 APC PC PMC7668396__F1 PI3K pathway RPS6 TSC2 KIT PTEN CCND1 PMC12125839__F5 Neurodegeneration models in Parkinson’s disease: cellular and molecular paths to neuron death MCOLN1 PINK1 LRRK2 TFEB PARK2 MTOR PMC5603960__F2 Biosynthesis of azaphilone pigments in Monascus fungi H1-5 MTR H1-1 PMC12125839__F2 Molecular mechanisms of mitochondrial damage involved in Parkinson's disease BAX SNCA PMC12011818__F11 Proposed model of HPV E2-mediated suppression of innate immune signaling TBK1 STAT1 CGAS MAVS TLR3 STAT2 IFNAR2 IRF9 IFNAR1 IRF3 JAK1 PMC6099942__F7 DBTD decreases the intracellular TG by promoting fatty acid B oxidation and inhibiting lipogenesis through blocking the mTOR pathway TG ACOX1 NR1C1 NCOR1 FASN CYP4A11 PMC8730700__F3 Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location CXCL9 CXCL12 HGF CCL11 CXCL1 IL2RA CXCL8 PMC3263550__F2 Parkinson's disease pathway from the KEGG disease database TH GPR37 SNCA PTEN SNCAIP STX1A PMC8872267__F1 Therapeutic Metabolic Reprograming Using microRNAs: From Cancer to HIV Infection HEL-S-133P HIF1A PMC4560923__F2 Yeast MAPK signaling pathways are associated to hypersensitivity to cell wall stress conditions CDC42 FAR1 PMC11211258__F1 Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment GSDMD NLRP3 GSDMC GZMA GSDMB AIM2 DFNA5 IRF8 PMC2858442__F3 Model of CD95-mediated signaling C6 HEL-S-62p CS PMC2680672__F2 Regulation mechanisms for Itch-mediated Th2 differentiation.TCR triggering plus CD28-mediated costimulation results in the activation of MEKK1-JNK signaling pathway, which induces the serine/threonine phosphorylation of Itch FYN ITCH C2 JUNB NDFIP1 PMC8289875__F2 Longitudinal genome-wide methylation study of PTSD treatment using prolonged exposure and hydrocortisone TH PLCE1 CACNA1H DKK1 LRP5 CREBBP PRKCZ BDNF PMC7141330__F2 Hepatitis C virus (HCV) sensing by the intracellular innate immunity throughout the virus life cycle TBK1 MAVS TLR3 IRF9 IRF1 IRF3 JAK1 TYK2 PMC6250284__F1 The nicotinamide adenine dinucleotide (NAD) synthesis pathway NRK NAPRT NAMPT PMC8025242__F3 Metabolism-modulating activity of IL-17 signaling in health and disease KLF15 KLF3 KLF2 IL33 UCP1 PMC4513933__F2 Summary of the interactions between the PI3K/AKT pathway and RUNX2 with integration of the TGFB pathway SNAI2 MMP14 SOX9 GSK3B MMP2 IHH PTEN MMP9 SMURF2 RUNX2 PMC6331066__F7 Model for EBV related chemoresistance.Notes: EBV activates the ATR-mediated DDR pathway, which is characterized by enhanced phosphorylation of the pathway proteins RPA32, CHK1, and H2AX ATR RAD51 H2AX PMC3013518__F1 Vitamin D3 biotransformation pathway CYP2R1 CYP27B1 CYP24A1 CYP27A1 PMC2930854__F10 Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development CDC42 PI3 PMC4694682__F5 Polyphenols activate Keap1/Nrf2/ARE pathway and increase the expression of detoxification/antioxidant enzymes.Notes: In the cytoplasm, Keap1 protein is always bound to Nrf2 transcription regulator and prevents its signaling KEAP1 PRX PMC7393270__F8 Ingenuity Pathway Analysis regulator effect networks analysis of differentially expressed (DE) genes between Muc1−/− vs TLR3 STAT2 SNCA RSAD2 OAS3 DHX58 ISG15 DNASE2 OAS2 GBP2 IKBKG PMC7393270__F7 Ingenuity Pathway Analysis regulator effect networks analysis of differentially expressed (DE) genes between Muc1−/− vs NR1i1 PPARG MTTP FABP1 FABP2 SCD SLC2A2 CXCL3 PMC7052940__F1 FGF/FGFR signaling pathway involved in resistance to oncotherapy STAT3 EGFR CCND1 MGMT PMC11771116__F3 Putative pathophysiological mechanisms leading to the incidence of amyloid-related imaging abnormalities (ARIAs) in the brains of patients with Alzheimer’s disease (AD) TIMP1 C1S C1R APOE MMP9 C4B_2 PMC4893057__F1 Sequence elements and protein components involved in the formation of poly(A) tails POLI POLE CP PMC8407980__F9 Alterations and Potential Roles of MCMs in Breast Cancer ATR GAL tmp_locus_29 ATM PTEN PMC4107319__F8 GIV/Girdin is a central hub for pro-fibrogenic signalling networks during liver fibrosis FOXO1 TLR4 SMAD2 PMC6293652__F7 Mechanism model of PIK3CA E542K and E545K mutation-mediate regulation of proliferation and glucose metabolism via the Beta-catenin/SIRT3 in cervical cancer SIRT3 GSK3B LDHB CTNNB1 PMC8714844__F6 Recent Progress in Lymphangioma EPHB4 EFNB2 PIK3CA VEGFC GLA CS MTOR PMC9255545__F1 Drug targets in the IL-23–IL-17 pathway IFNG IL17RC IL17RA PMC7697104__F1 Coupling of glucose metabolism with insulin secretion in pancreatic Beta-cell FH CD36 SLC25A13 MPC1 PDK2 SLC25A15 MPC2 FFAR1 UCP2 PCK2 SLC25A22 SLC25A12 SLC25A18 OGDH SLC25A1 MDH2 SDHC SLC25A29 PMC7918468__F4 Cellular contributors to tau-dependent degeneration NLRP3 CX3CR1 CX3CL1 PMC8480040__F2 Long non-coding RNA H19 in the development of osteoporosis DKK4 FOXC2 MSC JAG2 RUNX2 CTNNB1 PMC11876172__F1 Signaling pathways and associated genes with mutations linked to hyper-IgE syndrome TGFBR2 STAT3 ERBIN DOCK8 BCL10 ZNF341 CARD11 TAB3 IL6 TRAF6 TGFBR1 PMC5928601__F3 Arachidonic acid and linoleic acid metabolism signaling pathways LTB LTA LIF HEL110 PMC10311254__F1 Unlocking the power of precision medicine for pediatric low-grade gliomas: molecular characterization for targeted therapies with enhanced safety and efficacy TSC1 NF1 BRAF PTEN MTOR KRAS PMC12104568__F2 CTLA‐4 mediated inhibition in T cells CD80 APC MTOR LCK PMC8366957__F7 Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis KEAP1 NQO1 GPX3 PMC1924866__F6 Striped view of multiple data types LPL APOC2 HRH1 PON3 APOC1 DGAT1 ADRA1A APC APOE PON2 ADRB3 LIPC ADRA1B HMGCR SCARB1 ADRA2A ADRA2B ADRA2C FBP1 ADRB2 LDLR ADRB1 HRH2 PMC8114706__F7 Aging signal of C RHEB EEF2K TSC2 EIF4B TSC1 EEF2 MYC SIRT1 EIF4E WDR24 HDAC6 PMC6826402__F1 Proteomic workflow for the investigation of molecular determinants of acquired resistance to cetuximab CDCA2 JUP SRI VASP SDCBP FLNB PXN HEL-S-133P RPLP0 EGFR DSG2 S100A2 ATXN2 EPHB2 CRK ACTR2 RELA LSR CSK ARF4 HEL-S-87p AHNAK SRC LPP PMC1924866__F5 Striped view of multiple time-point comparisons TNFRSF1A PTGS1 PTGFR PTGER2 PTGER3 ANXA3 ANXA4 ANXA6 HEL-S-7 ANXA2 HSD11B1 ANXA1 PTGS2 TNF PTGDR PTGIS HPGD CYP11A1 PTGER1 HSD11B2 EDN1 EDNRA EDNRB PTGER4 PTGIR PMC10531058__F2 SIRTI 1 pathway FOXO1 SIRT1 PMC10531058__F1 Lnc-RNAs in the Pathogenesis and Development of Diabetic Retinopathy MTOR IRS1 PMC10531058__F4 TGFB pathway BAMBI PMC3429771__F5 Opposing roles of FGF2 and BMP4 in directing TB formation from epiblast type ES cells and iPS cells and the need to exclude FGF2 from the growth medium to minimize the co-induction of mesoderm and endoderm HLA-G BMP4 BMP2 BMP7 FGF2 PMC2230579__F10 Left, the mechanism, described by , for the proapoptotic function of TSP1 or 2 FAS VLDLR CD36 VEGFA SRC PMC10531058__F5 Nuclear factor erythroid 2 related factor 2 (NRF2) pathway KEAP1 SOX2 PMC11928779__F10 One carbon (1C) metabolism AMD1 CBL MTAP DHFR pcap MTR HEL-S-64p PMC6904269__F3 Schematic depiction of downstream mediators of the IL-36 signaling pathway IL36A IL36B MYD88 PMC10215600__F1 Nrf2 and SIRT1 signaling pathways regulation by antioxidants MT3 KEAP1 FOXO3A PTEN SIRT1 PMC3667713__F4 Molecular Rheostat at the Interface of Cancer and Diabetes EGFR IQGAP1 PMC6721565__F1 Canonical WNT signaling RNF43 APC LRP5 LRP6 GPR49 CTNNB1 LGR6 PMC6721565__F3 LRP6 and WNT/Beta-catenin pathway alterations in epithelial cancers RNF43 DKK1 APC LRP6 CTNNB1 PMC7391798__F2 Autophagy PCR chip and KEGG PATHWAY database analysis NBR1 USP30 FIS1 SP1 PGAM5 MFN1 MFN2 AMBRA1 BNIP3 ATF4 OPTN PMC3484421__F2 The PI3K/Akt/mTOR pathway: Ligands binds to the receptor tyrosine kinases like EGFR, IGF1R, Her2, and Ras leads to conformational changes and activates PI3K RHEB BAD EGFR GSK3B PTEN IGF1R MDM2 MTOR EIF4E PMC11563829__F2 Major downstream events of Trop-2 ADAM10 IGF1R SRC PMC2660380__F3 Lysophosphatidic Acid Signaling in Airway Epithelium: Role in Airway Inflammation and Remodeling LPA HBEGF EGFR LYN PMC10539942__F1 Ferroptosis in effects of anesthetics on multiple organ diseases: A literature review STAT3 KEAP1 GPX4 LPCAT3 FACL4 PMC2886153__F1 Schematic representation of the intracellular cholesterol transport pathway NPC2 NPC1 PMC11505051__F5 Pathogenesis of inflammatory skin disease and aging by PM exposure and associated ROS signaling pathway BAX LORICRIN BAD COX2 AHR IL1A IL6 PMAIP1 TNF PMC11505051__F3 Onset and exacerbation pathogenesis of chronic inflammatory respiratory disease by PM exposure and associated ROS signaling pathway IFNG TJP1 COX2 IL13 MUC5B IL4 IL6 IL5 CCL2 MPO PMC5171696__F1 Anaplastic lymphoma kinase (ALK) signaling: Pathway figure that depicts normal activation of ALK through ligand binding JUN PTN ALK MTOR PMC9166621__F8 Systematic Review and Meta-Analysis of Phytoestrogen Protects Against Myocardial Ischemia/Reperfusion Injury: Pre-Clinical Evidence From Small Animal Studies BAX NLRP3 USP19 TLR4 ARHA PMC4133204__F10 Qishenyiqi Protects Ligation-Induced Left Ventricular Remodeling by Attenuating Inflammation and Fibrosis via STAT3 and NFKB Signaling Pathway STAT3 MMP2 MMP9 PMC4391119__F6 Schematic summary of findings GDF8 FOXO1 FOXA2 PMC8589435__F4 Crosstalk between canonical and non-canonical Wnt, Hippo and Notch signalling pathways LATS1 WNT3A DKK1 ATOH1 BMP4 FZD7 LRP6 RHO GPR49 HES1 AXIN2 YAP1 PMC6085667__F5 Compound–target network CYP2A6 GSK3B HIF1A CHRM3 CCNA2 CCL5 CCL2 MAOA MAPK14 IFNG CDKN2A ADRA1B ALOX5 NQO1 F10 THBD MMP2 MMP3 KDR HEL-S-44 LPL MAPK1 ND1 NOS2 PTGER3 MIF TNF GSTM1 CHRM2 CDKN1A ADRB2 CALM1 BCL2 ADRB1 VCAM1 F7 NR1C2 COL3A1 AKR1B1 MPO COL1A1 ADAM17 RXRB ADH1C ACHE HEL-S-117 PIM1 FASN CYP1B1 ARHA STS NR3C2 MGAM ENPP2 CD40 PPARG CTPS2 WNT16 ATP2A1 ADH1A RALA ARF5 SRC GSTM2 CSF2 VEGFA RXRA CDK2 HEL-S-22 CDC42 EGF GRIA2 HGF CHRM1 MSMO1 ADRA1A EGFR ACACA HTR2A MTOR CTNNB1 PLAT MAP2K4 F2 PDE3A F3 IL2 TLR7 IFNA1 IL1B CDC2 CYP1A2 CHRM5 JUN NR1H3 SELE TET1 PTPN1 PTPN11 IL6 PTGS2 CHPF HEL-S-130P RELA CHEK1 XDH CYP3A4 GJA1 PMC4091735__F1 Evading apoptosis in cancer BAX BAD BOK BMF HRK BIK PMC6085667__F6 Targets of signaling pathways CD40 GSK3B HIF1A CCNA2 CCL2 IFNG CDKN2A RALA MMP3 KDR SRC LPL NOS2 PTGER3 VEGFA TNF CDKN1A ADRB2 CALM1 CDK2 BCL2 ADRB1 VCAM1 EGF HGF ADRA1A EGFR ACACA MTOR COL3A1 COL1A1 IL2 TLR7 IFNA1 RXRB IL1B CDCA2 CDC2 CHRM5 JUN NR1H3 PIM1 SELE FASN PTPN11 PTGS2 IL6 ARHA RELA CHEK1 PMC7598934__F6 MDA-7/IL-24-mediated inhibition in progression of PC-induced bone metastasis through modulation of the bone microenvironment IL24 GSK3B NFATC1 PMC3155297__F1 General and organelle-specific stress response pathways influenced by the ageing process IGF1 HSF1 EIF2A PMC8712697__F3 Comparative Genomic Analysis of Labrenzia aggregata (Alphaproteobacteria) Strains Isolated From the Mariana Trench: Insights Into the Metabolic Potentials and Biogeochemical Functions NAPB PMC5536000__F5 Schematic of the miR-206 regulatory mechanism during adipogenesis LPL FABP4 CTNNB1 EIF4E PMC2700405__F1 The canonical Wnt/Beta-catenin signaling pathway APC GSK3B AXIN1 LRP5 LRP6 CTNNB1 PMC9414397__F4 Protein-Based Adjuvants for Vaccines as Immunomodulators of the Innate and Adaptive Immune Response: Current Knowledge, Challenges, and Future Opportunities TBK1 TAB3 MAL IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC3136489__F10 Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood BAD BTK EGR1 PLCG2 CSK BLNK PTEN LYN GRB2 MTOR UNK PMC4431773__F1 Anti-HCV drugs targeting viral life cycle CD81 CLDN1 PMC9045034__F3 Anti-tuberculosis drug candidate pipeline and mechanism of drug action PMC3136489__F11 Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood ZAP70 TEC SLA FYN SHB BAAT LAT ITK GRB2 LCK PMC5362574__F8 Suggested model TF IFNG STAT1 SRC PMC4951198__F10 Molecular and physiological defects in mice lacking BRAF and RAF1 in the epidermis TSLP RAF1 IL13 CCL7 IL18 BRAF IL4 IL2 IL6 IL5 PMC9318090__F2 Scheme of molecules and pathways involved in DR and their relationship ANGPTL8 ANGPTL4 LRP6 PMC2840217__F7 Changes in cell cycle regulation in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells RB1 CD2 NDN CHEK1 ATM TOP2A PMC6203794__F1 Tumor-induced CD8+ Treg cells and their potential role in tumor microenvironment CTLA4 FOXP3 PMC2840217__F6 Antioxidant and phase II detoxifying enzyme genes in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells JUN BATF GATA1 KEAP1 MAK MAL AIP IL4 EPHA1 FOS H1-2 HEL-S-20 MAF GCK HEL-S-64p GPT HEL-S-44 PMC2840217__F9 Parkinson's disease (PD)-related gene pathway in response to MG132, methylmercury (MeHg), and cadmium (Cd) in MEF cells CASP9 GPR37 UBE2C UBE2J1 HEL-S-67p ARIH2 SNCA SNCAIP USP29 INS HEL-117 ARIH1 BTRC PACRG USP2 UBL3 CASP3 USP21 STX1A USP26 UBAP1 PMC5412884__F1 Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease EGF WNT3A EGFR DLL4 APC NUMB PTEN GPR49 CTNNB1 PMC6254660__F7 Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation PGP PTEN HIF1A MTOR MYC PMC3830525__F4 Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells CDC42 RAB5B EGR1 KLF5 PMC5866434__F2 Effect of CO on cellular inflammation pathways NLRP3 TLR4 PMC2840217__F8 Alteration in Ubiquitin-Proteasome System (UPS) in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells PSCA PMC8465636__F6 Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation MTHFD2 ATF3 ATF4 PSPH HEL-75 PMC11913833__F10 Regulation network by ACS on the innate and adaptive immune systems of young rabbits NLRP3 TLR4 APC NOD2 NOD1 PMC9600461__F3 Boosting Neurogenesis in the Adult Hippocampus Using Antidepressants and Mesenchymal Stem Cells CA3 WNT3A GSK3B MSC WNT1 HEL-S-11 WNT3 BDNF WNT7B PMC9213082__F8 Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression SOCS1 AXL TLR4 TRAF6 MYD88 PMC4007596__F2 Cytoscape plugin was used to analyze within Balb/c up-regulated genes, genes interaction within the same pathway and across different pathways MAPK1 JUN HTT PMC8743723__F8 Long non-coding RNA AC122108.1 promotes lung adenocarcinoma brain metastasis and progression through the Wnt/Beta-catenin pathway by directly binding to aldolase A MMP7 APC GSK3B HEL-S-87p CCND1 CTNNB1 PMC4671322__F1 Molecular mechanisms underlying the oncogenic metabolic phenotype EGFR PTEN IGF1R MTOR MYC PMC4007596__F3 Cytoscape plugin was used to analyse within C57Bl/6 up-regulated genes, genes interaction within the same pathway and across different pathways HSD17B10 MTOR NDUFC1 PMC4530889__F7 Dysregulation of the Transforming Growth Factor B Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia SMAD2 SMAD4 TGFBR1 PMC9687381__F2 Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation EBP XBP1 PMC4214431__F1 Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut ZEB2 TWIST1 PMC5744080__F8 GF1 mechanism of preventing ox-LDL-induced inflammatory injuries through activating A20-mediated NFKB signal pathway IL16 TLR4 APOE PMC3733962__F1 Proteomic Analysis of Signaling Network Regulation in Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2A Expression DKFZp434N041 TP53BP2 HEL-S-67p CCT4 RPLP2 LBR CKAP2 HSPD1 ACTN4 SH3BP4 ARHGEF2 UBE2L3 YWHAG PMC8435533__F7 Schematic figure showing EMP3 signaling pathway YTHDC1 EMP3 MTOR PMC8071327__F1 Sphingolipid metabolism and compartmentalization CERT1 SET PMC4309684__F8 Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization NEDD8 FBXW7 SKP1 KRAS PMC8071327__F5 SphK1 and S1P signaling in colorectal carcinogenesis and progression STAT3 SPHK1 TNF SKI PMC5628093__F2 Crosstalk between Panx1 and ligand-gated receptor channels PANX1 C2 SRC PMC4370098__F7 Signalling mechanisms regulating phenotypic changes in breast cancer cells ACLY TSC2 TSC1 C2 CSK PTEN MTOR SRC PMC4466682__F9 EGF-reduced Wnt5a transcription induces epithelial-mesenchymal transition via Arf6-ERK signaling in gastric cancer cells EGF EGFR ARF6 PMC5907632__F1 Etirinotecan pegol metabolic pathway UGT1A1 APC CYP3A4 PMC5318911__F7 Identification of miRNA-mRNA Modules in Colorectal Cancer Using Rough Hypercuboid Based Supervised Clustering BAX CASP9 MSH6 DCC BAD APC CASP3 SMAD4 RHO CTNNB1 PMC6406581__F3 Mammalian target of rapamycin (mTOR) pathway PRR5 PPARG ULK1 DEPTOR PMC6277783__F2 Schematic representation of various processes during seed filling stage in both monocot (top left) as well as dicot (top right) plants SI HP GPT PMC3721368__F1 Schematic depicting the canonical and noncanonical TGFB signaling systems coupled to EMT in MECs STAT3 SMURF1 SMAD2 SMAD4 HEL-S-28 ARHA MTOR SRC PMC7013724__F3 Mitochondria unfolded protein response (UPRmt) UBL5 CLPP ATF4 PMC2882865__F2 Transcriptional regulation by E2F complexes modulates cell-cycle control, cell fate, and survival HDAC1 SUV39H1 NOTCH1 PMC7899890__F6 Interaction between tumor necrosis factor and tumor necrosis factor receptor 2 signaling TRADD ITCH SELE MLKL EDN1 CASP3 IL6 TNF FADD PMC2692221__F1 BER subpathways for damaged bases and DNA strand breaks OGG1 MPG PCNA PMC2777383__F1 Predictive Phosphorylation Signature of Lung Cancer STAT3 CRK CASP9 JUN BAD PXN EGFR GRB2 MTOR SRC MYC GJA1 PMC10299596__F1 BCR signaling pathway and BTKis resistance in CLL SYK BTK BCR PLCG2 BLNK LYN MTOR SRC PMC2906469__F3 Progressive inactivation of GSK3B may promote increased anti-apoptosis and oral cancer BAX GSK3B BCL2 FADD PMC11992733__F6 Targeting PRDX2 to inhibit tumor growth and metastasis in triple-negative breast cancer: the role of FN1 and the PI3K/AKT/SP1 pathway SP1 HEL-S-2a PMC2906469__F4 Targeting GSK3B pathway may be highly beneficial for curing oral cancer EGFR APC MTOR PMC8355588__F5 Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients ABCG1 ABCA1 PMC8069026__F1 Illustration of the metabolism of galactose through the Leloir pathway HEL-S-19 GAL PGM2L1 PGM2 PMC7501700__F6 AD-integrated pathway and functional modules CDC42 CD40 EGF TRADD EGFR MTOR TRAF6 PRKCB COX2 TLR4 PRKCA CHUK HEL-S-11 BAX JUN HEL-S-133P VEGFA TNF SHE RAC1 IRS1 EIF4E HEL-S-162eP RELA CALM1 ERBB2 ENO1 GRB2 BDNF TRAF2 PMC7406690__F2 Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways LATS1 MOB1A TAOK1 MOBKL1A TAOK2 LATS2 TEAD2 TEAD3 TAOK3 VGLL4 TEAD4 PMC8699889__F8 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer IFNG PNP IFNAR2 APC TNFSF10 PMC8699889__F7 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer TAPBPL IDE ATR NPEPPS APC PSMB2 GANAB FURIN IFNG BCAP31 PSMB10 ATM CFTR DAP PSME2 PMC8699889__F6 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer HMGCL SUCLG1 ACAT2 SUCLG2 RAP1A ACACA XBP1 ACADM PMC8699889__F5 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer RAN ATR GLS APC WEE1 CDK2 ATM SKP1 CDC34 SKP2 CDK4 CP PMC10708062__F10 Analysis of DEGs involved in citrate cycle pathway in roots under osmotic stress ACLY SDHA SDHB OGDH PC HEL-S-32 CS MDH2 HEL-S-26 SDHC PMC3286397__F11 Campylobacter jejuni-induced Cdc42 activation CDC42 EGFR RHO SRC PMC9033871__F3 Inflammation and atherosclerosis: signaling pathways and therapeutic intervention TBK1 LTA TIRAP IRAK1 IRF3 IRF7 TRAF3 IRAK4 MYD88 PCSK9 TLR1 GSDMD MAP3K7IP1 NLRP3 PMC4364658__F1 MiRNA targeted signaling pathways in four different important cells including plaque macrophage, platelet, monocyte and endothelial cell NGF EGFR APC RHO SKP2 PMC11043956__F7 SSYYJN ameliorates CKD-induced muscle atrophy by inhibiting ferroptosis in tibialis anterior muscle cell via HIF-1A/SLC7A11 pathway SLC3A2 GPX4 SLC7A11 PMC7212757__F1 Role of Excitatory Cerebellar Nucleocortical Circuit in controlling associative motor learning PC CS DCN PMC3461933__F1 Looking in the miR-ror: TGFB–mediated activation of NFKB in glioma EGF EGFR LIF NFKBIA SOX2 ID1 PMC4364658__F6 MiRNA targeted upregulated genes of Rho GTPase signaling DEPDC1 RHOF RHOBTB1 FGD2 ARHGAP30 KALRN TSN ARHA RHO ARHGAP29 ARHGEF18 ARHGAP5 RHOU ARHGEF9 ARHGEF11 PLEKHG5 ARHGEF12 RHOB HEL159 ARHGEF4 SRGAP3 ARHGEF7 PMC3533285__F11 SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation CXCL2 GPS2 TWIST1 PMC3434350__F1 Translational impact of the mTOR signaling pathway CD44 RPS6 EIF4G1 HEL113 EIF4E PMC8699889__F9 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer MADD CDC20 APC INCENP KNTC2 NSL1 CENPC CENPB PMC3759360__F2 When Ubiquitin Meets NFKB: A trove for anti-cancer drug development LTB RELB POLI ATM TRAF3 TRAF6 PARP1 PMC8093449__F2 In silico Gene Set and Pathway Enrichment Analyses Highlight Involvement of Ion Transport in Cholinergic Pathways in Autism: Rationale for Nutritional Intervention ACHE ChAT KCNN2 PMC9361019__F6 Stemness Analysis Uncovers That The Peroxisome Proliferator-Activated Receptor Signaling Pathway Can Mediate Fatty Acid Homeostasis In Sorafenib-Resistant Hepatocellular Carcinoma Cells TF NR1H3 CYP8B1 SCD RXRB PMC3953890__F1 EGFR-axis pathway that contributes to cyst formation and progressive enlargement in ADPKD and ARPKD HBEGF TGFA GRB2 PMC9266896__F1 Interleukin 15 in Cell-Based Cancer Immunotherapy STAT3 JAK3 JAK1 IL15RA PMC4272425__F9 Proposed model of Pofut1 involvement in commitment of myogenically differentiated cells through activation of the Notch signaling pathway MB POFUT1 PAX7 PMC7912342__F6 CGAS-STING signaling pathway CGAS IRF3 PMC6090282__F13 Signaling pathways activated by temozolomide in glioma cells JUN TRPC1 MTOR SRC FOS MGMT PMC6331329__F5 InterferonG regulates cell malignant growth via the c-Abl/HDAC2 signaling pathway in mammary epithelial cells HDAC2 CCND1 CDK4 PMC7912342__F5 NLRP3 Inflammasomes signaling pathway P2RX7 CGAS NLRP3 IL1B PMC7912342__F4 RLR signaling pathway IRF3 IRF7 TRAF3 FADD PMC8093449__F5 In silico Gene Set and Pathway Enrichment Analyses Highlight Involvement of Ion Transport in Cholinergic Pathways in Autism: Rationale for Nutritional Intervention ACHE KCNJ14 GNAI1 KCNJ5 KCNJ6 CACNA1B SLC32A1 GAD1 BRAF TRPV1 GABBR2 MAPK3 GABBR1 KCNA1 KCNJ3 SLC18A2 TRPV2 CAMK4 SNAP25 SRC CREB1 PMC3845018__F3 Graft-versus-host disease signaling pathway and miRNA interactions obtained using IPA HGF CXCL10 TRAF6 TNF PMC7912342__F1 Toll-like receptor (TLR) dependent signaling pathways TBK1 TRADD TAB3 MAL TLR9 IRAK1 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 TLR10 PMC4364457__F3 MicroRNAs Are Part of the Regulatory Network that Controls EGF Induced Apoptosis, Including Elements of the JAK/STAT Pathway, in A431 Cells EZR TCP1 CCT6A HEL32 HEL-S-69p TUBA1B CAP1 BANF1 PS1TP5BP1 HEL-S-15 PMC8233862__F4 Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis IGF1 MSC MTOR PMC4386978__F1 Extracellular signalling molecules in the ischaemic/reperfused heart – druggable and translatable for cardioprotection? STAT3 PGC GSK3B PMC6456305__F6 GPs unmask cryptic variation in parallel signaling pathways and subpathways NRG1 SF1 TPK1 PMC9684800__F4 Roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors EPHB4 BMP10 SMAD1 DKFZp781O1323 APC IRAK1 MTOR SRC ID1 CTNNB1 PMC3749846__F3 Role of DMP1 and its future in lung cancer diagnostics JUN DMP1 MYC CCND1 CDK4 PMC8790423__F2 Statin as a therapeutic agent in gastroenterological cancer ARHA ERG PMC9101507__F4 Endocytosis at the Crossroad of Polarity and Signaling Regulation: Learning from Drosophila melanogaster and Beyond EGF EGFR RAB35 PMC8790423__F1 Statin as a therapeutic agent in gastroenterological cancer HMGCS1 HMGCR FASN LDLR PMC6986441__F1 Canonical pathway (Modified from IPA) for Opioid Signaling [−log(P-value) = 8.48; Z-score = 0.392] ADAR SLC12A5 BAD FOSB C2 GSK3B BRAF MB MYC FOS CTNNB1 PMC9559516__F5 RKIP in the Regulation of EMT in the Tumor Microenvironment EPCAM NECTIN1 ARHA PMC6986441__F3 Canonical pathway (Modified from IPA) for Dopamine Receptor Signaling [−log(P-value) = 2.97; Z-score = 1.89] MDK LEP GDNF CHRM1 CALY PTPRN OPRK1 CHRM4 SCG5 POMC CARTPT PTH LAG3 PMC4441763__F4 Quantifying Ubiquitin Signaling PINK1 USP2 OTULIN MFN2 USP21 PMC6986441__F2 Canonical pathway (Modified from IPA) for Corticotropin Releasing Hormone Signaling [−log(P-value) = 3.74; Z-score = 1.29] KRT1 TH JUN GAL ADM CRH KCNK9 ATF2 PRLHR CRHR1 NPY2R PRKCE SCARB1 COX2 POMC UCN SHH CARTPT PMC8303227__F1 Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target ERCC1 ATR PMS2 BRCA2 BLM PNKP BACH1 APLF ATM POLE PALB2 MSH6 RAD52 MSH2 MSH3 FEN1 WRN SSB XPC BARD1 DDB2 LIG1 BRCA1 PAXX RTEL1 SLX4 EME1 PMC3279943__F1 PI3K and STAT3: a New Alliance RHEB STAT3 TSC2 PMC7601167__F1 Graphical abstract depicting the mechanisms of inherent and acquired resistance to PI3K inhibition at different vertical nodes along the PI3K/Akt/mTOR pathway PIK3CA CDK6 MTOR CCND1 CDK4 PMC4936558__F6 Genes up- and downstream of flavonol biosynthesis are also affected in the Δy mutants MYB CCR2 CCR3 GSTZ1 PMC11721291__F7 CGAS/STING activity CGAS IRF3 TREX1 PMC4113246__F3 Gene Regulatory Networks in Cardiac Conduction System Development HCN4 SHOX2 TBX3 TBX5 PITX2 PMC6986441__F5 Canonical pathway (Modified from IPA) for GABA Receptor Signaling [−log(P-value) = 5.07; Z-score = NaN] ABAT GABARAP GPHN UBQLN1 SLC32A1 ALDH9A1 GABRA4 GABRQ PMC8557524__F3 Targeting CD47 for cancer immunotherapy WAS SIRPA CD47 PMC9316483__F2 Study on the Molecular Mechanism of High Altitude Heart Disease in Children EGLN1 HIF1AN NR1C1 ANGPTL4 EDNRA PTEN EP300 PMC6986441__F4 Canonical pathway (Modified from IPA) for Serotonin Signaling [−log(P-value) = 2.04; Z-score = NaN] SPR DDC PMC1936363__F1 Epidermal growth factor receptor pathway BAD GSK3B PTEN PDK2 MTOR CCND1 PMC8481641__F2 Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes ZAP70 IFNG HEL-S-92n PRF1 BNIP3 SIRPA CD47 PMC5422340__F4 TGFB1-mediated regulatory network via Ingenuity pathway analysis CEBPE STAT3 RARA SP1 NFKB1 RELA NFKBIA INS PMC6637653__F7 Breast cancer cell-based pathobiochemical pathways showing LPHN-induced activation of PKCA, which triggers the translocation of Tim-3 and galectin-9 onto the cell surface which is required for immune escape GIP FLRT3 PMC5422340__F3 P53-mediated regulatory network via Ingenuity pathway analysis STAT3 JUN SP1 TNF FOS NR3C1 CTNNB1 FOXO3A CEBPD RELA NFKBIA ERBB2 CEBPB PMC8660623__F8 Bone morphogenetic protein 9 enhances osteogenic and angiogenic responses of human amniotic mesenchymal stem cells cocultured with umbilical vein endothelial cells through the PI3K/AKT/m-TOR signaling pathway VWF SMAD1 DKFZp781O1323 MTOR RUNX2 PMC4619170__F7 Even-skipped+ interneurons are core components of a sensorimotor circuit that maintains left-right symmetric muscle contraction amplitude ATR RP2 PMC8303227__F4 Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target CDC2 BRIP1 RAD52 MSH6 TOPBP1 ATR RAD50 RAD51 RCC2 BRCA2 MDC1 SSB BARD1 RAD1 MRE11A BRCA1 CDK2 ATM PALB2 CP PMC5988934__F1 Activation of antiviral innate immunity in CHB PDC TLR9 TLR8 IRF3 IRF7 TLR7 MYD88 PMC1176468__F9 Crosstalk model of ATF3 and c-myc in serum induction ATF3 ATF2 SRC PMC7588667__F4 DNA damage response in amyotrophic lateral sclerosis FUS HDAC1 RBM45 RNF168 RNF8 ATM SQSTM1 ATXN2 VCP PARP1 PMC4782221__F5 SYK tyrosine kinase: a crucial player in diverse biological functions TREM2 SYK PLCG2 OSCAR HEL-S-11 PMC5192357__F1 Action of blockade of inhibitory pathways or activation of costimulatory pathways to promote CD8+T cell priming after vaccination CD40 TNLG8A CTLA4 FOXP3 PMC10136857__F1 Canonical and non-canonical Wnt signaling pathways in cholangiocytes and the role of the primary cilia in modulating these pathways APC LRP5 LRP6 ARHA RAC1 CTNNB1 PMC10534279__F4 Growth differentiation factor 15 in cancer cachexia (Review) STAT3 BAX SMAD2 CRH SMAD4 GFRAL MAP3K11 CCL2 TGFBR1 GDF15 GC POMC NPY RET PMC10534279__F3 Growth differentiation factor 15 in cancer cachexia (Review) SMAD1 DKFZp781O1323 SMAD2 GDF15 SMAD4 ERBB2 GFRAL MTOR RET PMC11528463__F7 BC-derived CAV1 promoting BC lung metastasis NLRP3 TLR4 SFTPC MMP9 SRC CCL2 PMC5733215__F4 STAT3/S1P/S1PR1/SPHK1/SPL-positive feed-forward loop promoting CAC STAT3 S1PR1 SPNS2 SPHK1 PTEN CYLD PMC8909868__F3 Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma STAT3 SMAD2 TRPC6 PMC3581520__F1 Differential Intrahepatic Phospholipid Zonation in Simple Steatosis and Nonalcoholic Steatohepatitis LPCAT4 LPCAT2 LPCAT3 PEMT PC LPCAT1 CHKA CHKB PMC8909868__F2 Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma CDH2 BAX SIRT3 KEAP1 MMP2 MDM2 NOTCH1 PMC12066790__F9 Oncogenic mechanisms of EBV in lymphoma OGG1 TIGIT DPP4 NFKBIA WAS TAP2 NRF1 GABPA CCL20 HEL-117 PMC12066790__F6 Oncogenic mechanisms of HPV in cervical cancer EGF ATR CGAS FAS HEL-S-133P EGFR HIF1A TERT CCL5 MYC CCL2 CTNNB1 CCL21 COX2 E2F4 WAS FADD PMC9323628__F3 Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis USP14 FOXM1 USP12 USP19 EGFR BAP1 USP11 USP22 MYC USP26 USP16 HEL-117 PMC12066790__F5 Oncogenic mechanisms of EBV in gastric cancer STAT3 PIK3CA CCL22 BAD THBS1 APC IHH KHSRP PTEN IGF1R MMP9 VEGFA CTNNB1 VHL CXXC4 DKK1 PBRM1 WTAP MMP2 GCNT3 LAG3 PMC6396132__F3 Hedgehog signaling and Wnt signaling in the primary cilium FZD3 PTCH1 SMO CTNNB1 PMC7825432__F3 Glycolysis reactions and the reactions of encapsulated enzymes (GDH + AAT) in erythrocyte HEL-S-162eP DAP PMC12066790__F7 Oncogenic mechanisms of EBV in nasopharyngeal carcinoma STAT3 ROS1 ATR CCL22 BAD FH ANXA3 TNFAIP3 KEAP1 HEL-S-133P GPX4 HK2 EGFR SMAD2 SMAD4 SLC7A11 MTOR TGFBR2 GLUD1 CDKN2A AHR PMC12066790__F4 Oncogenic mechanisms of HBV and HCV in hepatocellular carcinoma STAT3 HMGB1 FAS TGFB1 TXNIP HK2 EGFR SMC5 TERT CTLA4 CTNNB1 SMC6 AFP CDK2 GCK PMC8705881__F1 MicroRNAs Regulate Cell Cycle and Cell Death Pathways in Glioblastoma STAT3 CDK6 EGFR PTEN MDM2 GRB2 MMP9 MTOR SLC31A1 MGMT CDK4 PMC7820019__F8 Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24 TSC2 TSC1 C2 MTOR PMC3328827__F2 Beyond inactivation of the MEN1 gene, additional mutations in other genes may be responsible for acceleration of tumor growth, thus involving a process of multistep tumorigenesis JUN RAF1 PTEN MTOR MYC CCND1 FOS CTNNB1 PMC7334796__F6 Distribution of partial targets of ATR and CR on the compressed pathway FLT3 PLN ATR JUND TRADD GSK3B CHRM3 HTR2A VEGFA TNF INS TRAF6 CHRM2 INSR IKBKB RXRA ADRB2 CASP3 CHUK BCL2 KDR GRB2 PMC3851046__F7 Proposed molecular mechanism for the inhibitory effects of zinc on RANKL-induced osteoclastogenesis SYK ORAI1 SIRPB1 OSCAR NFATC1 TRAF6 PMC11173094__F3 Natural products that modulate specific proteins in the molecular pathway of inducing and inhibiting ferroptosis IREB2 TF SLC3A2 SLC40A1 MAP1LC3A GPX4 LPCAT3 FACL4 SLC7A11 HIF1A FTMT POR HMOX1 TXN TFRC WWTR1 DKFZp762B153 DPP4 ALOX15 ALOX12 TFAP2C ATF4 AIFM1 ATG5 SLC11A2 SP1 AIFM2 YAP1 ATF3 FTH1 FTL NEDD4 GCLC NFE2L2 HEL110 HILPDA ALOXE3 HEL-S-64p CP HEL-75 PMC3383648__F1 Vismodegib HHIP PTCH2 SUFU PTCH1 SMO GLI3 PMC5795664__F4 Mutations in various genes in the JAK/STAT pathway (MPL, CRLF2, JAK1, JAK3, JAK2, LNK, SOCS1, STAT3) implicated in hematologic malignancies SOCS1 STAT3 MPL JAK3 JAK1 CRLF2 PMC5893443__F8 Dual Catenin Loss in Murine Liver Causes Tight Junctional Deregulation and Progressive Intrahepatic Cholestasis LRP5 LRP6 CTNNB1 PMC9326561__F4 Integrative Proteomic and Phosphoproteomic Analyses of Hypoxia-Treated Pulmonary Artery Smooth Muscle Cells APRT EHD2 ARHGAP1 BET1 CTPS2 DCTN4 SMAD2 SPARC PCCB CLTB C1QBP MRPS18A TMED10 PSMD3 PDPK1 HEL-S-29 CLTA COL4A2 UQCRH PC NACA TMSB10 ZNF326 RBM27 SLIRP SYAP1 BASP1 MRPL53 SERPING1 MRPL50 DKC1 RPL12 LMAN2 HK2 TCEAL4 MICALL2 HEL-S-84 SNF8 TBL2 PTGFRN PPP6C CHD4 ENG ANGPTL4 PPWD1 HNRNPA2B1 SUPT16H HEL-S-115 COL12A1 TSPAN4 SNW1 PSAP COL5A2 PPP4R2 ACOT13 HEL60 IRF2BP2 ENO2 CXCL1 PPP3R1 PTMS COL3A1 MRPS22 TPM1 NUFIP2 TFRC CA12 NOLC1 COL1A1 LYAR TXN2 HEL-S-108 LARP4B ZFR PWP1 GNPTG PPM1F COL1A2 YBX1 ME1 HMGN1 ERH CAPRIN1 FTH1 GRSF1 PBDC1 NAT10 PMC9316001__F2 Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review CDH2 STAT3 EGFR RXRA MTOR SCT CDK4 CTNNB1 PMC3399091__F1 PAK1 Molecular Pathway BAD CDK5 RAF1 PAK1 PCBP1 FLNA ARPC1B PMC5108321__F9 The working model of AMDE-1-induced canonical and noncanonical LC3 lipidation ATG10 ATG12 ULK1 WIPI2 GCA ATG5 PMC4842122__F1 Signaling pathways involved in SSc pathogenesis that may also play a role in EndoMT SMAD2 PTCH1 SHH SMAD4 SMO HIF1A NOTCH1 PMC8302073__F1 Live Cell Imaging of Nuclear Actin Filaments and Heterochromatic Repair foci in Drosophila and Mouse Cells SPAG4 RAD51 SMC6 SMC5 ATM BLM PMC2494567__F10 Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closure TGFA EGFR GET1 PMC8490739__F7 SMYD3/ITGB6/TGFB1 Positive Feedback Loop Promotes the Invasion and Adhesion of Ovarian Cancer Spheroids CDH2 ITGB6 TGFB1 SMYD3 PMC8194669__F2 Karyopherin abnormalities in neurodegenerative proteinopathies RCC1 RAN PMC8716696__F4 Impact of Rubella Virus Infection on a Secondary Inflammatory Response in Polarized Human Macrophages STAT1 TIRAP STAT2 IRF3 JAK1 TYK2 MYD88 PMC6110909__F1 Direct and indirect mechanisms of action of metformin in cancer cells RHEB TSC2 TSC1 SLC22A1 MTOR PMC4547205__F2 Ingenuity pathway analysis comparing gingivitis to healthy subjects PPARGC1B FOXC2 NR2A2 PPARGC1A TRIB3 NRF1 INS PMC8657018__F1 Promising Antigens for the New Frontier of Targeted Immunotherapy in Multiple Myeloma STAT3 SLAMF7 IKZF1 JAK1 PMC9324879__F8 New EGFR Inhibitor from Ficus benghalensis Exerted Potential Anti-Inflammatory Activity via Akt/PI3K Pathway Inhibition COX1 COX2 EGFR PMC3573709__F3 Protein-protein interaction network of NFY and associated genes NASP MSH2 UNG MYC PMC2637758__F5 Pathways and networks associated with HSPA9, PHB, and ABCB6 RB1 HDAC1 STAT3 TGFB1 KLK3 IL6 ENTPD2 SMARCA4 PMC8996962__F2 Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer CD40 TRADD TRAF3 TRAF2 PMC11749133__F4 Immune responses by bufalin in cancer therapy CAMKK2 NOD2 SLC7A11 REL PMC11749133__F3 Astragalus-mediated inhibition of tumor growth RAB27A KLF2 FAS EREG CTNNB1 PMC11749133__F2 Impact of traditional Chinese herbal preparations on cancer pathways JUN TLR4 TNF MYD88 PMC6966574__F4 Summary of deregulated genes within different glucose metabolism related pathways and the potential use of certain genes as independent predictors for OS and /or RFS ACLY HEL107 FAS GYS2 HK3 PCK1 ENPP1 PYGL ALDH2 F2 LDHD PC OGDHL AGL SLC2A9 GLYCTK PFKFB4 PYGB DERA SLC2A2 SLC16A4 PCK2 SDHD PDK4 ALDOB ENO3 PFKP HEL-S-162eP SLC16A2 ALDH9A1 ENO1 HEL-S-87p HEL-S-41 RBKS IDNK PMC7692959__F3 XIAP Signaling Pathways in Human Cancer FUS MAP3K7IP1 SP1 EGFR MMP2 PMC5831762__F2 Simple diagrammatic representation of the (known) key events in Shh signaling at the primary cilium EVC GPR161 KIF7 BOC SUFU PTCH1 GSK3B SHH SMO GAS1 GLI3 PMC6895808__F1 Progression of thyroid cancer and the main genetic alterations involved in such process PPARG PAX8 BRAF TERT PTEN RET CTNNB1 PMC6433817__F4 Some possible interactions between fungal cell regulatory hierarchies that could respond to oxidants and chemical stresses ATF1 GPX3 YAP1 PMC7878386__F1 Leptin receptor isoforms and intracellular signaling STAT3 SOCS3 GRB2 IRS1 PMC8285540__F7 Model depicting the role of FBXO32 in the crosstalk between CHOP-dependent apoptosis and autophagy LAMP2 CASP3 BCL2 ATF2 PMC6411369__F7 Molecular mechanism of miR-194-5p in HPC involves the mTOR signaling pathway by targeting SMURF1 SMURF1 PCNA MTOR PMC7980524__F1 Structural and functional understanding of the toll‐like receptors TBK1 MAL TLR9 TLR5 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 TLR10 PMC4755870__F5 MicroRNA variants as genetic determinants of bone mass HOXA10 APC RUNX2 SFRP1 CTNNB1 PMC8393865__F3 Concurrent BMP Signaling Maintenance and TGFB Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear SMAD9 SMAD1 TNFAIP3 ITCH COPS5 SMAD2 SMAD4 TRAF6 TRIM63 STUB1 TRIM62 TRAF4 USP15 USP4 TTC3 USP18 CYLD USP11 SMAD6 FBXO30 USP9X WWP1 NEDD4 MAP3K7 SMURF2 RNF111 PJA1 RLIM PMC8393865__F2 Concurrent BMP Signaling Maintenance and TGFB Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear MUSK SKIL SMAD9 SMAD1 GDF8 ADAMTS4 DKFZp781O1323 MEF2B BMPR1A SMAD2 MYF5 SMAD4 RGMA CD109 BAMBI MAPK14 TRAF4 INHBB INHBA TOB1 GDF11 MMP2 SP1 STK17B PPM1H FBXO30 SKI YAP1 TFAM HGS EDN1 MAP3K7 BCL2 BMP5 KCP TGFB1 ZFYVE9 RANBP9 YY1 COL3A1 VEPH1 TGFBR1 TGFBR2 ERBIN COL1A1 MSX1 FKBP1A PPARGC1A ACVRL1 MAP2K3 GDF10 SIK1 THBS1 RGMB ZFYVE16 GDF5 gdf7 MAP3K7IP1 TWSG1 ACVR1 MGP PPP2R2A BMP2 RGS4 BMPER GDF1 KAT2A SPARC TRAF6 TRIM63 SOSTDC1 ID4 SP3 CTGF NBL1 DCN BMPR2 ACVR2B ACVR2A ID2 ROR2 TGFBR3 PPM2C HFE2 ATF3 BMP6 MYOG ENG COL6A1 CTDNEP1 CHRDL1 MTMR4 COL5A2 SIRT1 STRAP MMP14 TIMP1 CDKN2B RUNX2 MEF2C TGFBRAP1 TMEPAI ACVR1B FST BMP4 NOG GREM1 KLF10 HOXC8 ZCCHC12 HMGB1 COL1A2 SMAD6 BMP7 COL14A1 ID1 ID3 PRKAA2 KAT2B PMC3074954__F1 ROS have different origins PNKP FEN1 PCNA APTX SSB PARP1 PMC8623825__F1 Endothelial Dysfunction through Oxidatively Generated Epigenetic Mark in Respiratory Viral Infections KEAP1 HEL-S-44 PMC8655846__F2 TypiCal but DeliCate Ca++re: Dissecting the Essence of Calcium Signaling Network as a Robust Response Coordinator of Versatile Abiotic and Biotic Stimuli in Plants MYB ERF CBL RAB18 PMC8655846__F1 TypiCal but DeliCate Ca++re: Dissecting the Essence of Calcium Signaling Network as a Robust Response Coordinator of Versatile Abiotic and Biotic Stimuli in Plants TF CBL FER PC HEL-S-11 NCL PMC7037725__F1 Molecular mechanisms underlying GOLPH3 function in human cancer STAT3 GOLPH3 MAJN PITPNC1 EGFR ARHA RAB1B MTOR CTNNB1 PMC7673857__F1 Main source of ROS and redox reaction NOX4 PMC3317213__F4 Metabolism of xenobiotics by cytochrome P450 pathway, and ribosome map views of identified proteins IDE LPO SI PMC9287557__F3 One carbon metabolism SLC25A38 MTHFD2 MTHFD1 DHFR MTHFD1L SHMT1 MTHFD2L SFXN1 TYMS HEL-S-51e PMC4698510__F1 Molecular mechanisms of alcohol-related liver pathogenesis and therapeutic targets TG CYP2E1 ADIPOR1 IRF3 IL6 SIRT1 PMC8850794__F2 PI3K/Akt/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles CDH2 BAX CXCL12 PIK3CA FOXO4 GSK3B CASP3 BCL2 PTEN ARHA CXCL8 CTNNB1 PMC9284214__F1 Insights on the cGAS-STING Signaling Pathway During Herpesvirus Infections COMP GAS IRF3 PMC8850794__F1 PI3K/Akt/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles FOXO1 PTEN MDM2 MTOR PMC4629436__F1 Representative HIF-1A regulatory genes and their effects on cancer progression LEP TGFA ID2 ADM HEL-S-133P HK2 IGFBP1 EPO IGFBP2 HEL-S-30 IGF2 PMC9284214__F2 Insights on the cGAS-STING Signaling Pathway During Herpesvirus Infections TBK1 CGAS TRIM9 CSK OTUD5 IRF3 IRF7 TRAF6 ZCCHC3 PMC5968093__F1 Antibodies that target leukemic stem cells (LSCs) and blasts directly CD27 TNLG8A CD33 TNIK TRAF2 CTNNB1 PMC4629436__F3 Regulation of HIF-1A pathway at different levels MDM2 MTOR VHL PMC5094977__F7 Identification of myeloproliferative neoplasm drug agents via predictive simulation modeling: assessing responsiveness with micro-environment derived cytokines RB1 IFNG BAX BCL2L1 SHC1 CASP3 BCL2 PTEN IL6 TNF PMC8576385__F3 Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout MYLK CAST BAD C2 MAL PMC8371910__F2 Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease IFNG ICOS CD80 IL33 CTLA4 PMC6189061__F5 Proposed model of irisin effects on pancreatic cancer PC MTOR CCND1 PMC4594598__F2 RhoGEF signaling pathways involved in 3D migration CDC42 LPA BMI1 ARHGAP22 DOCK10 DOCK3 ARHA NET1 SRC NEDD9 RAC1 PMC10343815__F5 Differentially expressed genes in the cAMP metabolic pathway suggested that upregulated genes were dominant in this pathway OXT VIP BAD CFTR GIP NPY GHRL AMH SST PMC5909795__F1 Regulation of the core components of the Hippo signaling pathway.Abbreviation: ER, estrogen receptor LATS1 LATS2 TEAD2 TEAD3 RHO VGLL4 TEAD4 PMC8057882__F10 Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation BAX H2AX FOXO3A PMC3371699__F4 miR-519d, miR-190, and miR-340 in the TGFB signaling pathway NOG BMP2 SMAD4 SKP1 ARHA CHAD MYC DCN PMC4138699__F7 GAi-mediated activation of the PI3K-Akt-mTORC1 pathway in response to EGF EGF GSK3B PMC2954312__F2 Crosstalk between the three distinct oscillators that function in the mouse PSM.(a) Schematic diagram of a signalling and a responding cell in the mouse PSM, detailing cyclic genes of the Notch, Fgf and Wnt pathways NKD1 TF WNT3A APC NRARP DUSP4 AXIN2 CTNNB1 SPRY2 FGFR1 LFNG HES7 LEF1 PMC5909795__F2 The Hippo pathway regulates organ metastases by controlling cell proliferation, EMT, and immune evasion.Abbreviation: EMT, epithelial–mesenchymal transition LATS1 LATS2 PMC7547073__F2 MicroRNA-34a targets the colorectal cancer pathway CASP9 PIK3CA JUN DCC BAD CYCS SMAD4 MYC KRAS AXIN2 FOS CTNNB1 ARAF TGFBR2 CASP3 BCL2 MAP2K1 LEF1 CCND1 PMC7962413__F2 Tick signaling-related genes in the three main immune signaling pathways of arthropods: (A) Toll, (B) IMD, and (C) JAK/STAT ECSIT CACTIN FADD PMC6160419__F5 Extracellular matrix organization pathway genes in COPD disease network module MMP7 FAM13A FBN1 ADAMTS4 MMP12 CHRNA7 IHH SPINK5 STC2 MMP9 CTSG pp6425 MMP11 ENG NID2 LOX MFAP2 CHRNB2 DPT BMP2 ELANE FBN2 PRSS1 VASN PMC6066232__F1 Study of purinosome assembly in cell-based model systems with de novo purine synthesis and salvage pathway deficiencies PAICS HEL-S-70p PFAS ADSL PMC7024605__F2 Metabolic Immunomodulation of Macrophage Functional Plasticity in Non-Healing Wounds IL16 TLR4 AASS IL1B PMC9264807__F2 SLC7A11 in Cancer: Friend or Foe? CD44 SLC3A2 UFM1 KEAP1 PRC1 SLC7A11 ATF4 KDM3B IRS1 PMC9264807__F1 SLC7A11 in Cancer: Friend or Foe? IFNG GLS GPX4 SLC7A11 PMC6899468__F5 Schematic diagram showing the PST inhibition of gluconeogenesis in hepatocytes C2 GC PLCB3 PCK1 IRS1 PMC9147666__F2 Therapeutic Strategies for Ovarian Cancer in Point of HGF/c-MET Targeting STAT3 HGF GRB2 MTOR RAC1 PMC6899468__F4 Schematic diagram showing the putative signaling pathways for the anti‐inflammatory actions of CST TRADD NLRP3 TNF TRAF2 PMC7880341__F5 NSCLC-pathway CSA2 CASP9 LTA RAF1 TRADD COX2 MEI1 TNF RAC1 PMC6899468__F2 Schematic diagram showing the inhibition of catecholamine secretion and regulation of cardiovascular functions by CST NTS CGA PMC11003275__F1 Schematic chart for molecular mechanisms of metabolic dysregulation in DCM FAS CD36 CPT2 PMC2678244__F1 Abl Tyrosine Kinases in T-cell signaling ZAP70 PLCG1 APC ITK VAV1 RAC1 LCK DOCK2 PMC9293612__F2 Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma STAT3 CXCL12 CD24 CCL15 CCR6 CCR2 SIRPA CXCR4 CCL2 CCL20 CD47 CCL17 PMC7583966__F3 Interferons after ligating to type II receptors activate JAK/STAT pathway resulting in foam cells formation leading directly to atherosclerosis development IL19 STAT1 IL24 JAK1 ABCA1 PMC12229470__F6 Molecular mechanism by which AloAB suppresses HNSCC progression via inhibition of the STAT3/SLC7A11 signaling CDH2 STAT3 LPO FACL4 SLC7A11 PMC10300995__F2 Altered amino acid metabolism and potential drugs in DLBCL SIRT3 GLS MYC PMC9363460__F2 Key steps of the mevalonate (MVA) pathway leading to sterol and non-sterol isoprenoid synthesis ACLY HMGCR CYP11A1 LDLR CH25H FDPS PMC10300995__F4 Influence of altered tumor metabolism on immune cells SUCNR1 ARG1 PMC9363460__F1 Non-exhaustive representation of lipid metabolic pathways addressed in the review ACLY FAS CD36 CPT2 PMC10300995__F3 Altered fatty acid metabolism and potential drugs in DLBCL ACLY CD36 FASN PTEN MTOR PMC9363460__F3 Non-exhaustive scheme of lipid exchanges between tumor cells and tumor microenvironment (TME) cells and lipid reprogramming of stromal cells, that activate their pro-tumoral features LPA ABCG1 HBEGF CD36 APOE LDLR ABCA1 PMC6361534__F1 Complement cascade and its regulators C6 CD59 HEL-S-62p C9 C4B_2 PMC6488628__F4 The cellular functions of the PLAC8 up-regulated genes MLH3 CPA2 DGIC PMC7882000__F1 De novo synthesis and regulation of cholesterol ACAT1 CYP7A1 DHCR24 DHCR7 PMC3544567__F2 Differentially expressed genes within the Wnt Signalling pathway APC SKP1 ARHA PMC6361534__F3 Mechanisms through which complement modulates T cell-mediated rejection C5AR2 C5AR1 HEL-S-62p C3AR1 APC FOXP3 PMC12210318__F2 Complete RNM for the MAPK Cancer Cell Fate Network of Grieco et al MAX EGFR FGFR3 MYC PMC6070710__F11 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response BAD FAS TNFRSF10B CYCS TNFRSF25 PMAIP1 TRAF3 MYC BCL2L1 NFKBIE BOK CHUK MDM2 CRADD HRK APAF1 JUN CASP2 TNFSF6 BNIPL TNF MAP3K1 NFKB1 RELA NFKBIA BCL2 TRAF1 MAPK10 BIRC2 TRAF2 NFKBIB DIABLO FADD PMC7415428__F12 Schematically drawing the diagraph for illustrating the signaling pathway and pointing the action sites of melatonin BAX PARP4 PTEN PMC6070710__F10 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response ATR TGFB1 CDC20 PCNA BUB1B ARF1 ORC6 CDC6 GSK3B SMAD4 CCNA2 E2F5 SKP2 PLK1 CCNH PTTG2 HDAC3 CCND2 E2F3 E2F6 ATM HEL-S-1 MDM2 CCNB1 HDAC2 HEL2 CDC2 MCM9 ESPL1 E2F2 APC SMC1A ORC2 HDAC1 RBL1 PTTG1 CCNE2 MCM10 PRKDC CDC45 MCM3 MCM5 HDAC7 EP300 MCM6 UBE2F MCM2 YWHAZ PMC2933206__F7 Hypothetical model of how Str1 may affect cellular behavior via the Beta-catenin/LEF signal transduction pathway APC CCND1 CTNNB1 PMC8794658__F8 Investigating the Molecular Mechanism of Xijiao Dihuang Decoction for the Treatment of SLE Based on Network Pharmacology and Molecular Docking Analysis MADD CD40 TRO TIRAP APP PMC1828075__F2 Diagram showing several factors involved in lens development PROX1 FOXE3 SIX3 BMP4 BMP7 PMC9182402__F5 Transcriptome Profiling of HCT-116 Colorectal Cancer Cells with RNA Sequencing Reveals Novel Targets for Polyphenol Nano Curcumin UBE2C GADD45G BUB1B MAFA CLSPN ZWINT PLK1 FOXM1 BTG1 DKK1 SPC24 GADD45B CENPU ERCC6L CENPF JUN DNAJB1 EGR1 POLE2 SELL E2F2 TUBB ATF3 SPC25 AURKB DDIT3 BDNF PMC7775424__F5 Hypothetical contribution of exRNA to virus infection and subsequent cardiovascular disease NRP1 ACE2 RAC1 PMC10888344__F9 Molecular mechanism that drives the positive impact of CSE in OVA-induced AR mouse model MBP IL33 TNF PMC8147868__F2 Epigenetics of Hepatic Insulin Resistance USF1 IGFBP2 IRS1 HDAC3 TFAM PROX1 NR2A1 GRB10 JMJD1C IGF1 INSR FOXO1 PHF2 SIRT1 PMC11314049__F5 Schematic illustration of reactive oxygen species (ROS)-mediated activation of various cell signaling pathways in the skin BCL2 ATF2 PMC7801517__F7 ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway BAX S1PR2 GEM BCL2 PMC7716140__F1 Figure shows the pharmacological effects of ulinastatin BAX TLR4 MYD88 PMC7732991__F7 OXER1 and RACK1-associated pathway: a promising drug target for breast cancer progression OXER1 PMC5759779__F3 Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer's disease COX1 IGF1 PLD2 PMC4652780__F6 Network overview of the biomarkers in lung cancer and ALL CD79B PIM2 DDR1 CANX MAPK13 PAXIP1 CD36 UTP20 ILF3 PSMB2 PEX2 ACACA HEL-S-70p REM2 VCAN HEL-S-99n LCT RAPGEF1 BCL2 EHMT1 CPSF6 POLE PMC8278085__F7 PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin‐II by reducing TGF‐B1/Smads pathway activation SMAD2 DDR2 TNLG7C PMC5348352__F5 miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival CDH2 PTEN MMP9 YWHAZ PMC7461028__F6 PI3K-Akt signaling pathway is downregulated in U87 glioblastoma cells overexpressing ZNF554 SYK BAD LAMA1 RPS6KB2 PTEN PPP2R5C MTOR MYC NTF3 ANGPT1 INSR BCR OSMR PDGFC MDM2 CCND1 CCND3 EIF4B THBS1 RBL2 CD19 RAC1 IRS1 EIF4E RHEB TSC2 CCNE2 TSC1 BRCA1 RXRA CDC37 GRB2 BDNF LAMA3 PPP2R5A YWHAZ PMC3875894__F3 mTOR signaling pathway (#hsa04150) RHEB TSC2 EIF4B RICTOR TSC1 HOXA9 BRAF MTOR EIF4E PMC4219921__F1 Steroid hormone synthesis pathways in the adrenal gland and testis HSD3B2 CYB STAR CYP17A1 CYP11B2 CYP11A1 STS PMC3875894__F1 Pathway Protection Loop RICTOR TSC1 PMC9456549__F2 Targeting PI3K/AKT/mTOR Signaling Pathway in Pancreatic Cancer: From Molecular to Clinical Aspects TSC2 PTEN MTOR PMC4061877__F4 Hypothetical outcomes for demyelinated axon.Denuded axon impermissive for myelination TGFBI MOG LINGO1 PMC3509687__F1 Impact of the cellular restriction factor APOBEC3 (A3) on human immunodeficiency virus-1 (HIV-1) replication ATR ATM ULBP2 PMC3875894__F4 Antigen processing and presentation (APP) pathway (#hsa04612) IFNG TAPBP CANX B2M PMC4219921__F2 Classical and non-classical pathways of androgen biosynthesis CYP17A1 STAR AKR1C1 UGT2B17 STS DIO1 UGT2B15 HSD3B1 CYP11A1 HSD17B2 RDH5 AKR1C2 CYP7B1 PMC4040584__F1 Expansion of the SDF-1/CXCR4 migratory signaling network in breast cancer stem cells HEL113 TLK1 CDK7 ITGB4 HEL-S-80p ARFGEF2 MAP2K2 CDK3 CXCR4 PTPN13 MYO9B PMC3894712__F4 Autophagy in Kidney Health and Disease ATG12 MTOR ATG5 PMC5601256__F3 Natural killer (NK) cell activating receptor signaling ZAP70 SYK FYN RAE1 VAV1 GRB2 LCK PMC9453876__F14 Honokiol improves depression-like behaviors in rats by HIF-1Alpha- VEGF signaling pathway activation PSD EPO MTOR PMC9027058__F2 KRAS: A Druggable Target in Colon Cancer Patients EGF EGFR GRB2 MTOR PMC9477010__F3 Pyroptosis and its crosstalk with immune therapy in breast cancer STAT3 BAX GSDMD DRD2 NLRP3 GSDMC AIM2 DFNA5 PMC9477010__F1 Pyroptosis and its crosstalk with immune therapy in breast cancer NLRP1 HMGB1 GSDMD NLRP3 GSDMC GZMA GSDMB AIM2 DFNA5 PMC6614129__F3 Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders HDAC1 BAD GSK3B HDAC2 TRAF2 PMC8299191__F6 Map of dimorphic switching-related signaling pathways in Sporothrix schenckii based on its transcriptome CDC42 CIB2 GPD1 RALBP1 PMC8350388__F1 Role of Traditional Chinese Medicines by Wnt/Beta-Catenin Pathway Compared With Targeted Small Molecules in Colorectal Cancer Therapy EGF BTRC RNF43 EGFR APC GSK3B KRAS GPR49 CTNNB1 PMC5717492__F8 EMT signaling induced during P GSK3B MMP2 CTNNB1 PMC2852600__F2 CD40 responsiveness in Leishmania-infected macrophages: crosslinking of anti-CD40 antibody activates p38 MAPK-induced leishmanicidal function via iNOS2 induction CD40 STAT1 PMC4556375__F5 Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease PRMT1 HEL-S-182mP HMGCR PC PMC7656798__F1 PI3K/AKT/mTOR signaling pathway in cancer TSC2 TSC1 PTEN MTOR PMC3184251__F1 Smac mimetics and TNFA: a dangerous liaison? TRADD TNF TRAF2 FADD PMC5412537__F1 Diagram of IL-10 and IL-10R pathway STAT3 JAK1 TYK2 PMC5362499__F4 LncSubpathway: a novel approach for identifying dysfunctional subpathways associated with risk lncRNAs by integrating lncRNA and mRNA expression profiles and pathway topologies PERP PMC8616345__F2 Advances in Immunotherapy and the TGFB Resistance Pathway in Metastatic Bladder Cancer TF SMAD2 SMAD4 SMURF2 PMC8255536__F4 Proposed mechanism on cartilage repair and chondroprotective effects of IGF1-induced SMMSC-CM therapy ADAMTS4 SOX9 IGF1 IL13 BMP2 FGF18 PMC4099360__F1 Toll-like receptor 4 and hepatic fibrogenesis TIRAP TLR4 CD14 IRF3 TRAF6 LBP MYD88 PMC8900732__F1 The Cannabinoid System in the Basal Ganglia in Parkinson’s Disease TRPV1 GPR55 PMC5426649__F8 Hypothetical model for IGF-I regulation of kitlga expression and its signaling mechanisms in the zebrafish follicle cells EGF EGFR PMC8616345__F4 Advances in Immunotherapy and the TGFB Resistance Pathway in Metastatic Bladder Cancer TF SMAD2 SMAD4 SMURF2 PMC9271914__F1 Gut Microbiota-Bile Acids Axis in the Progression of Non-alcoholic Fatty Liver Disease FGF8A CYP7A1 FGFR4 CYP7B1 CYP27A1 PMC5083749__F1 Upstream and downstream signaling in the mTOR pathway BAX EGFR SSTR5 GSK3B BRAF ATM FGFR3 PTEN IGF1R MTOR MGMT VHL PMC11054859__F6 KEGG pathway (hsa05226 gastric cancer) POLK MUC2 APC SHH SMAD4 PMC11054859__F5 KEGG pathway (hsa05200 pathway in cancer) MAK STATH FADD PMC5267446__F3 Acute myeloid leukemia and oncogenic Hedgehog/GLI signaling FLT3 BRD4 DYRK1A DYRK1B SMO MTOR PMC12191077__F1 Proton-sensing GPCR-related signaling pathway GPR68 GPR132 GPR65 RHO GPR4 PMC7602033__F2 Cardiac remodeling by microRNAs and the functions of their target mRNAs STAT3 RAF1 PTEN PMC11054859__F7 KEGG pathway (hsa04151 P13K-AKT signaling pathway) POR RHEB TSC2 EIF4B BAD BCR RBL2 CD19 PTEN MTOR PMC3276472__F1 Schematic in vivo biosynthetic pathway from 18:3n3 and 18:2n6 mediated by ELOVL4 and other ELOVL family proteins ELOVL4 ELOVL3 ELOVL2 ELOVL1 ELOVL5 PMC2783774__F4 miRNA process pathway RAN DGCR8 TNRC6A DICER1 TARBP2 SNIP1 PMC3092604__F1 General scheme of the SBP in Tritryps CERS3 SMS PC KDSR PMC4981705__F1 PI3K/Akt/mTOR signaling pathway and the existing molecular targets for therapy, which was indicated by ∆ RHEB MLST8 TSC2 RICTOR TSC1 TTI1 PTEN MTOR DEPTOR IRS1 PMC3092604__F2 Lipid remodeling pathways in mammals, yeast and T PGAP2 PGAP3 PER1 BST1 CWH43 PMC11056518__F3 IL-23 and IL-12 and their receptors, with summary of associated effector cells, cytokines, and immune function STAT3 STAT4 IL23R TYK2 PMC9138510__F1 TGFB as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications TF TGFBR2 SMAD2 SMAD4 TGFBR1 PMC4755014__F5 KEGG pathway map (cin04310) of the WNT Signaling Pathway with DE genes indicated SOX17 SIAH1 ROCK2 APC LRP5 SMAD4 LRP6 ARHA CTNNB1 BAMBI RBX1 SOST INVS CER1 SKP1 NLK UNK DAAM1 PMC5368692__F2 MYC-dependent metabolic reprograming in immunity As schematically shown here, MYC regulates immune cell metabolic reprogramming in different contexts BCR MYCL MYC PMC4175497__F1 Molecular signaling altered in Fragile X syndrome ACHE MAP1B GSK3B APP ARC MMP9 PMC8048291__F9 Schematic depiction of endolysosomal pathway dysregulation in Huntington’s disease CD63 HTT PMC11655665__F0 Epoxy metabolites of linoleic acid promote the development of breast cancer via orchestrating PLEC/NFKB1/CXCL9-mediated tumor growth and metastasis CXCL9 NFKB1 PLEC CYP2J2 PMC12041774__F6 Effect of TCM monomers, formulations and small-molecule inhibitors on the Wnt/Beta-catenin signaling pathway WLS BCL9 NLK MYC CYLD LEF1 RAC1 CTNNB1 PMC12041774__F1 Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 CTNNB1 PMC12041774__F3 Effect of angiogenesis in CRC APC GSK3B LRP5 LRP6 IL6 CTNNB1 PMC8318642__F3 Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome BCR CMTM7 CMTM3 BLNK CMTM6 CMTM2 CMTM1 IL1B PMC11693507__F2 IL-6 signaling pathway in kidney cells STAT3 AXL CXCL5 SOCS3 PMC9606688__F2 mTORC1 beyond anabolic metabolism: Regulation of cell death LATS1 LATS2 KEAP1 ULK1 GCLM GCLC PTEN SLC7A11 NF2 SESN2 HEL-S-64p PMC8529048__F2 Anti-flavivirus Properties of Lipid-Lowering Drugs FAS HMGCR MVD DHCR7 PMC5811610__F6 Sialylation pathway in eukaryotes SLC35A4 SLC17A9 NANP SLC17A1 CMAS NANS SLC35A5 SLC35A1 PMC12234022__F3 Chemically modified ncRNAs in diseases YTHDC1 NSUN2 NOP2 DKC1 METTL1 GCLC WDR4 METTL14 NOP58 YTHDC2 HEL-S-15 PMC9393728__F8 EST12 regulates Myc expression and enhances anti-mycobacterial inflammatory response via RACK1-JNK-AP1-Myc immune pathway MYC TNF PMC5270476__F1 Reelin's role in stabilizing the cytoskeleton CDC42 CRK DAB1 VLDLR LIMK1 GSK3B MTOR PMC4453536__F8 Regulation pathway from HBV infection to complement activation CD59 CFH CD46 IRAK2 CD55 TRAF6 IL1B PMC12192919__F2 Myostatin-mediated muscle atrophy in SMA GDF8 SMAD2 PMC8146031__F2 Improving Gemcitabine Sensitivity in Pancreatic Cancer Cells by Restoring miRNA-217 Levels IGF1 MAL PTEN MYC PMC4875670__F2 Network of gene interaction NF-KB pathway obtained from the subtraction of the control Hep-2 cells ZNF675 DUSP9 EDAR CDC42SE1 PMC8146031__F8 Improving Gemcitabine Sensitivity in Pancreatic Cancer Cells by Restoring miRNA-217 Levels TP73 CD24 ATR HLA-DRA PTGS1 MICA AREG CXCR4 PMC3073487__F4 Functions of 14-3-3 in tumor-suppressor pathways LATS1 LATS2 CTNNB1 PMC10310986__F5 Histone post-translational modification and the DNA damage response HDAC3 SIRT7 BRCA1 TRIM66 SIRT1 PMC8990993__F5 Immunomodulatory Effect and an Intervention of TNF Signalling Leading to Apoptotic and Cell Cycle Arrest on ORL-204 Oral Cancer Cells by Tiger Milk Mushroom, Lignosus rhinocerus TRADD IL8RB FADD PMC6275466__F3 NOTCH signaling in B cell development NOTCH2 PREB NOTCH1 PMC6749531__F7 Active constituent-protein targets-signaling pathway network of frankincense–myrrh compound against breast cancer RAD51C ATR MSH2 BRCA2 PTPN1 NBN PTGS2 MTOR PALB2 CTNNB1 PMC7843420__F8 STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis STAT3 CD83 LIF CD151 MSC IL6 GRB2 TWIST1 IL6R GATA3 PMC6275466__F2 NOTCH signaling pathway CDK8 NUMB FURIN PMC8609314__F6 Activation of PTH1R alleviates epididymitis and orchitis through Gq and Beta-arrestin-1 pathways IL6 CXCL10 PTH1R TNF PMC8623313__F1 Kinase-Inhibitors in Iodine-Refractory Differentiated Thyroid Cancer—Focus on Occurrence, Mechanisms, and Management of Treatment-Related Hypertension MTOR RET PMC5138252__F4 Examples of genes (in red) within the HIF pathway in which positive selection has been identified in high-altitude populations EGLN1 NOS2 NR1C1 ARNT2 EPO HIF1A EGLN3 EGLN2 PMC6952783__F1 Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases CCL24 TRAF6 CCL17 PMC3870610__F8 Signaling pathway of the AMH protein SMAD1 DKFZp781O1323 SMAD4 AMHR2 AMH PMC8263891__F6 Therapeutic targets and biological mechanisms of Centella asiatica on hepatic fibrosis: a study of network pharmacology RELA APP INSL3 RXFP2 PMC8263891__F5 Therapeutic targets and biological mechanisms of Centella asiatica on hepatic fibrosis: a study of network pharmacology MAX TRO FAS CD14 HP NLK GCK PROC TRAF2 MEF2C PMC5297752__F1 Unfolded protein response (UPR) pathways in mammalian cells ATF4 TRAF2 PMC10605634__F1 Tumor intrinsic factors related to immune evasion and ICI resistance APC GSK3B SMAD4 IRF1 B2M HLA-B JAK1 HLA-C HLA-A LAG3 CTNNB1 PMC6408937__F1 T cell activation induces cell surface expression of GLUT1 and amino acid transporters, facilitating uptake of glucose and glutamine OGA OGT PMC9241034__F6 Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSA facilitates processing of oxidative DNA damage in human cells ATM SETD2 SET PMC12204016__S1 Expression of exosome miR-30a-3p was up-regulated in the lead (Pb)-exposed group, suggesting that the abnormal expression of exosome miR-30a-3p derived from osteoclasts may be involved in the Pb-exposed group TH GSDMD IKBKG PMC9427794__F7 Schematic model of GASP1 promoting malignant phenotypes of breast cancer cells and decreasing their response to paclitaxel by forming a positive feedback loop with the IGF1/IGF1R pathway IGF1 IGF1R MDM2 PMC2536824__F4 Ingenuity Pathway Analysis (IPA) of genes specifically overexpressed in B1-Arg389 transgenic mouse hearts SKIL EDNRA MAPK10 TIA1 PMC12176239__F1 RA signaling pathway regulates the dynamic balance of differentiation and proliferation in LECs FABP5 RBP1 LRAT CYP26A1 PMC10380640__F4 Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology MASP1 MASP2 C2 C9 C4A PMC8971670__F5 Targeting Oncoproteins for Degradation by Small Molecule-Based Proteolysis-Targeting Chimeras (PROTACs) in Sex Hormone-Dependent Cancers TMPRSS2 FKBP5 PMC12174920__F4 Molecular mechanism of KGN induced Hippo/TAOK1 Signalling Pathway MOB1A MOBKL1A PMC6715949__F1 Mucosal innate immune responses to STIs in the female genital tract that could potentiate HIV transmission risk IRF3 IRF7 IL1B MYD88 PMC9085972__F11 BAG3 regulation of Rab35 mediates the Endosomal Sorting Complexes Required for Transport /endolysosome pathway and tau clearance TBC1D10B BAG3 RAB35 PMC6898841__F5 The schematic presentation for the signaling of the top 3 kinases crucial for cardiomyocyte survival IGF1 IGF1R MTOR PMC8584457__F1 Targeting Inflammatory Signaling in Prostate Cancer Castration Resistance LTB RELB PPP3CC PMC7551521__F1 Immune responses induced by SARS-CoV-2 TBK1 MAVS IRF3 PMC5416822__F3 Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases CGAS CASP8 MAVS STAT2 IRF9 AIM2 MYD88 GBP5 RIPK3 STAT1 ZBP1 NLRP3 IFNAR2 TLR4 IFNAR1 TLR7 GBP2 FADD PMC4552438__F8 Paracrine networks acting downstream of epithelial ESR1 in the mouse uterus during implantation HBEGF PGR EGFR PTCH1 LIF BMP2 IHH PMC8102595__F1 Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves LPL KLF3 SMAD1 LEP BSCL2 EBP EZH2 SETDB1 FABP4 SIRT2 CTNNB1 CEBPA FBXW7 CTBP2 FOXC2 RBP1 CTBP1 BMP2 LPIN1 MSC SENP2 EGR2 PMC9395612__F2 Research progress on exosomes/microRNAs in the treatment of diabetic retinopathy TRADD SMAD2 SMAD4 PTEN TNF DOK5 TRAF2 PMC5132409__F3 Retinoid transformations and enzymes of the classical and intraretinal visual cycles RPE RDH14 RDH8 LRAT RPE65 RDH5 PMC6907741__F3 Regulatory Mechanisms of B7x Expression STAT3 RELA SMAD4 PMC3309773__F1 Regulation of ISGs by Akt1 and EMSY STAT1 EMSY STAT2 IRF9 IFITM1 ISG15 PMC7291868__F4 Common neuroinflammatory pathways in different neurological diseases regulated by miR-146a CFH IRAK1 TRAF6 MYD88 PMC6917592__F1 Induction and subversion of the innate IFN response by HCMV STAT3 TBK1 CGAS IFITM2 MAVS IRF9 IFIT1 IFITM1 IFIT3 TLR9 IFIT2 IRF3 MYD88 IFNG ZBP1 IFITM3 ISG15 JAK1 PMC8507163__F5 Identification of common microRNA between COPD and non-small cell lung cancer through pathway enrichment analysis RFWD2 PIK3CA RAF1 PIK3CD CYCS PIK3R1 RXRG MYC SKP2 EFS POR RB1 CDKN2A ALK E2F3 PRKCA HEL-S-1 FHIT HTT ANAPC10 PERP HRAS CRABP2 CDC27 MCM2 RAX ATR BAD PIK3R3 EGFR AKT3 BRAF PTEN RORA PRKCB RARB TTK ATM RXRB HEL2 BAX CASP2 E2F2 KRAS ORC2 EML4 ARAF POLK CASP3 SKP1 EP300 PMC2704251__F1 Porphyromonas gingivalis-Host Interactions: Open War or Intelligent Guerilla Tactics? TLR1 TIRAP CXCR4 MYD88 PMC2765277__F5 Amino acid producing elementary flux patterns ASIP GLS MAL CIT PMC4309737__F4 PTEN-PI3K-AKT pathway in oocytes regulates primordial follicle activation EGF KIT PTEN PMC2765277__F3 Scheme of part of the central metabolism of E MAL ASPA CIT PMC4309737__F3 Actin polymerization disrupts ovarian Hippo signaling and promotes nuclear YAP actions to increase downstream CCN growth factors and apoptosis inhibitors involvement in POI, PCOS, follicle reserve, and infertility LATS1 LATS2 FOXL2 TEAD2 TEAD3 DIAPH2 CTGF TEAD4 PMC11033207__F6 Redox signaling and skeletal muscle adaptation during aerobic exercise MT3 LTBR TRADD GPX4 SIRT4 RELB TNF LTB SIRT3 COX2 RELA MAF SIRT1 HEL-S-44 FADD PMC6709869__F2 Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging CDC42 CXCL12 NR1C1 TICAM1 MSC BCL2 MTOR SIRT1 PMC11033207__F1 Redox signaling and skeletal muscle adaptation during aerobic exercise AQP8 NOX4 PMC6882982__F6 Most significant module of PPI network of DEPs involved in ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathway LAMA5 COL1A2 LAMA1 COL4A3 ITGB4 LAMC2 LAMC1 COL3A1 LAMB1 COL2A1 COL4A4 AGRN ITGA1 COL4A6 ITGA6 LAMB2 COL4A1 LAMA3 PMC6882982__F5 PI3K-Akt signaling pathway changed in FSH-positive relative to negative NFPAs SYK BAD RBL2 PTEN CD19 MTOR RAC1 EIF4E RHEB TSC2 FAR1 BCR PI3 RXRA MEI1 MDM2 PMC3776022__F1 GABAA receptor subunit regulation after status epilepticus (SE) STAT3 BDNF PMC3309773__F7 The functional role of Akt1, EMSY, and BRCA2 in the regulation of ISGs EMSY STAT2 IFNAR2 IRF9 BRCA2 IFNAR1 JAK1 TYK2 PMC12174920__F8 Molecular mechanism of KGN induced JNK/RUNX-1 signalling pathway RUNX1 SOX9 RUNX2 CTNNB1 PMC12174920__F7 Molecular mechanism of KGN induced AMPK-SIRT1/Antioxidant signalling pathway SMAD9 SMAD1 DKFZp781O1323 SOX9 SP4 SMAD4 SIRT1 PMC12174920__F6 Molecular representation of repressed (left), in absence of hh ligands and activated (right) KGN induced hh signalling pathway, in presence of hh ligands DHH SHH IHH SMO GLI3 PMC8182896__F2 Ang/Tie signalling pathway under physiological and pathophysiological conditions FOXO1 IQGAP1 VCAM1 GRB2 VEGFA RAC1 TIA1 PMC7921686__F8 Integrated pathways map of fucosterol in the treatment of NSCLC include (A) the non-small cell lung cancer pathway, marked in yellow as the functional targets of fucosterol, and (B) the key signal transduction pathways CASP9 BAD FHIT DAO PMC7921686__F7 Target-pathway network, constructed in Cytoscape3.7.2 (https://cytoscape.org/), was built by the candidate targets and a pathway if the pathway was lighted at the target ERBB4 PGR JAK3 PTPN11 KIT MAPK8 RARA BMP2 CASP3 MMP2 MMP3 IL2 CDK2 KDR MDM2 PMC6138560__F2 Immunobiology of Ubiquitin-Dependent B Cell Receptor Functions SYK CBL ITCH PMC7917218__F1 The Unfolded Protein Response (UPR) is regulated by three transmembrane endoplasmic reticulum (ER) receptors: PERK, ATF6 and IRE1A ATF4 EIF2A XBP1 TRAF2 PMC9298971__F1 Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation IGF1 POMC AgRP PMC7603112__F1 Vitamin D metabolic pathway by cytochrome P450 oxidases (CYPs) CYP2R1 CYP27B1 CYP24A1 CYP27A1 PMC3931394__F2 Transcriptomic analysis of isolated islets from GLU+IL–infused 6-month-old rats UCP2 HBEGF PLK1 PMC3438361__F2 Illustration of the metabolic pathway analysis for zidovudine with thick arrows indicating targets identified by the automatic classifier CYP2E1 HEL-S-20 AMT SLC28A3 SLC22A11 CYP2C9 CYP3A4 UGT2B7 SLC22A6 NDP SLC22A7 PMC7519869__F7 Diagram presentation of the molecular mechanism CCND1 CTNNB1 PMC5794005__F1 Denosumab: Targeting the RANKL pathway to treat Rheumatoid Arthritis IFNG OSCAR NFATC1 TRAF3 TRAF6 PMC6931156__F2 Frontotemporal Dementia/Amyotrophic Lateral Sclerosis (FTD/ALS) and Parkinson’s disease (PD)-Associated Genes Converge on the Lysosome FUS TBK1 PINK1 SYT11 PFN1 LRRK2 TMEM106B SNCA GRN TMEM175 CHMP2B TMEM230 CHCHD2 CHCHD10 OPTN HEL-S-44 C9orf72 PMC6931156__F3 Rab Proteins Have Convergent Roles in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis (FTD/ALS) and Parkinson’s disease (PD) RAB10 TBK1 TMEM230 RAB1A RAB39B LRRK2 RAB35 CHMP2B C9orf72 PMC11694147__F7 Mechanism of protective effect of Herpetospermum pedunculosum seeds on liver KEAP1 SMAD2 SMAD4 PMC3321808__F4 Differential regulation of genes in the IL-10 pathway in neonates and school-age children with septic shock versus age-matched controls STAT3 SP1 HEL-S-29 SOCS3 TRAF6 TNF TYK2 LBP PMC2168724__F1 Coenzyme B12 biosynthesis in serovar Typhimurium APP NDP PMC3321808__F5 Differential regulation of genes in the antigen presentation pathway in neonates and school-age children with septic shock versus age-matched controls ALB IFNG HEL-S-99n MHC2TA HEL-S-269 PMC9233348__F1 Cytokines and microRNAs in SARS-CoV-2: What do we know? PIGF SOCS3 TNF ACE2 PMC3693579__F5 Signal transduction in MMTV-Pax8PPARG mice CD24 GSK3B PTEN CTNNB1 PMC3562414__F2A Surfactant phospholipid metabolism PGP PSD PEMT PC PMC5061430__F6 Role of the Tomato Non-Ripening Mutation in Regulating Fruit Quality Elucidated Using iTRAQ Protein Profile Analysis ERF EED CAD MB BAK1 PMC8926997__F7 Mechanism and Function of miRNA in Intervertebral Disc Degeneration CUL4A CUL4B PMC7768255__F3 Starvation Responses Throughout the Caenorhabditis elegans Life Cycle ALK PTEN PMC5787446__F4 Drug resistance related to aberrant glycosylation in colorectal cancer CD44 EGFR PMC5787446__F3 Drug resistance related to aberrant glycosylation in colorectal cancer ERCC1 ABCC1 ERCC2 CES2 CES1 SLC19A1 ATP7B C2 SLC29A1 ABCG2 ABCC2 ABCC11 ABCB1 PMC6379582__F6 Model hypothesizing the potential regulation of Beta-catenin by G-alpha subunits and PMT APC RHO CTNNB1 PMC9106457__F5 Exosomes in Chronic Liver Disease Development and Their Potential Clinical Applications SMAD4 PMC4655987__F1 Aerobic very long chain-PUFA biosynthetic pathways modified from Napier () including microorganisms, plants, and animals FADS6 GLA TNLG7C PMC9414791__F12 Walnut Prevents Cognitive Impairment by Regulating the Synaptic and Mitochondrial Dysfunction via JNK Signaling and Apoptosis Pathway in High-Fat Diet-Induced C57BL/6 Mice BAX IDE IL16 GC ChAT TNF PMC4960658__F2 p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression EGFR ERBB2 ARHA SRC RAC1 PMC9588904__F5 Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation MAX UGCG LACRT TXNIP THADA PTEN NAGK MTOR MYC NMRK2 COL4A4 STAC A2M ATM APP AHNAK PROC MUC12 MTHFD2 FBN1 UBC ST7 MRAP2 IGF2 HRAS PCK2 ITGAM FAM9B TFCP2 PIGA DHX29 SUFU EP300 HEPACAM2 PMC5935233__F3 Oncogene-induced genomic instability RAD50 RECQL4 BRCA1 WRN BRCA2 PALB2 BLM PMC7410499__F1 Functionally annotated network of genes involved in the hypertension-hypotension axis whose expression across the GTEx population is correlated and anticorrelated with the AGTR1 and AGTR2 receptors CTSA PMC5867859__F2 Wnt signalling in the adult Drosophila midgut during homeostasis, regeneration, ageing and hyperplasia HDC TNKS EGFR APC PMC9099915__F2 Towards Understanding the Gene-Specific Roles of GATA Factors in Heart Development: Does GATA4 Lead the Way? TBX5 GATA4 PMC3917548__F1 The interleukin (IL)-21 receptor signaling pathway STAT3 JAK3 IL21R SHE PMC3950548__F2 Representation of IL-33 pathway in T-helper cells IL33 IRAK1 TRAF6 IRAK4 MYD88 PMC2759052__F1 Signal transduction pathway mediated by epidermal growth factor receptor (EGFR) TSC2 EGFR MTOR PMC7047088__F3 HIF-mediated gene expression in metabolic reprogramming HEL107 LONP1 PFKFB1 TKTL2 PFKFB4 CITED2 ID2 HEL-S-133P HK2 BNIP3 PFKFB2 BNIP3L HEL-S-68p HEL-S-49 HEL-S-162eP ENO1 PFKL HEL-S-87p CA9 MXI1 PMC4155324__F4 Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma SP1 CCND1 PMC5722633__F4 Mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain SHANK3 SYNGAP1 HOMER1 SHANK1 SHANK2 PITRM1 SRCIN1 LRRC7 HOMER2 BAIAP2 HOMER3 PMC11077374__F3 HuR during Wnt/Beta-catenin signaling pathway, autophagy and drug resistance in pancreatic cancer WEE1 WTAP EIF3B HEL-S-26 CTNNB1 PMC7511812__F7 Major molecular pathways IL16 CDK9 IL1B PMC11077374__F1 LncRNAs in modulating the Wnt/Beta-catenin signaling pathway in pancreatic cancer TEX10 PYGO2 APC LRP6 EZH2 WDR5 CTNNB1 FOXM1 FOXO1 DKK1 HOXA9 FOXO3A WTAP CTBP1 BRI3 EIF3B TOP2A WIF1 PMC11077374__F7 HIF in regulating Wnt/Beta-catenin signaling pathway and autophagy in pancreatic cancer CDK8 PGAM1 VMP1 SMAD4 BNIP3 TCF4 EGLN2 PMC11077374__F5 FOXM1 in regulating Wnt/Beta-catenin signaling pathway and autophagy in pancreatic cancer FOXM1 CTNNB1 PMC11077374__F4 FOXO1 and FOXO3 in regulating Wnt/Beta-catenin signaling pathway and autophagy in pancreatic cancer FOXO1 FOXO3A NOX4 SIRT1 CTNNB1 PMC11077374__F8 FOXO3-FOXM1 axis in regulating drug resistance in pancreatic cancer CD44 FOXM1 PDHA1 FOXO3A PMC11855704__F3 Wnt/Beta-catenin pathway in the pathogenesis of obesity STAT3 OSBPL2 CXXC5 ADD1 NOTUM LRP5 UCP1 RYK ARHA CTNNB1 PMC6952374__F7 Role of ALK5 and non-canonical androgen signaling in ADPKD GPRC6A SMAD2 OXER1 PMC11855704__F2 Application of MAPK, PI3K, and JAK/STAT signaling pathways in the pathogenesis of obesity UCP2 IGF1 POMC UCP1 NPY AgRP Nucb2 IRS1 PMC4810556__F1 Inhibition of innate immunity by arenavirus NP and Z MAVS STAT2 IRF9 MAL IRAK1 IRF3 IRF7 TRAF3 TRAF6 MYD88 IFNG STAT1 IFNGR2 TLR1 IFNAR2 IFNAR1 JAK1 TYK2 PMC7268735__F1 Illustration of CDC25C regulation (Green arrows indicate the enhancement effects and red indicator lines indicate the inhibitory effect) CDC2 ATR C13orf34 WEE1 ATM PLK1 PIN1 CDK4 PMC4763866__F1 Schematic pathway of SOCE in neutrophils, leading to activation of the NAPDH oxidase ORAI3 STIM2 ORAI1 STIM1 PMC9525271__F8 ADH1C inhibits progression of CRC by ADH1C/PSAT1/ serine metabolic pathway ADH1C PHGDH PSAT1 PSPH PMC8147992__F2 Fibrotic Events in the Progression of Cholestatic Liver Disease JAG2 SMO FZD1 HES1 CTNNB1 PMC5368180__F1 Nanotechnology-based therapy for prostate cancer CD44 PSCA CTNNB1 PMC7641946__F2 Therapeutic Application of MMEJ for Cancer Treatment ATR WEE1 PMC7641946__F1 DSB Repair Pathways RAD51 FEN1 HMCES PMC3540819__F1 Main signaling pathways involved in thyroid carcinogenesis are the MAPK and PI3K-AKT pathway (reproduced with permission) BRAF PTEN MTOR PMC3686815__F9 Regulated Extracellular Choline Acetyltransferase Activity— The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway ACHE APOE ChAT PMC12226585__F1 ADSCs/ADSCs-exosomes mediates a multidimensional network of mechanisms for IRI repair STAT3 BAX HGF PCNA FGF21 NQO1 CTNNB1 MPO PMC8616591__F2 Glypican-1 in regulating multiple cellular signaling pathways GPC1 RNF43 LRP5 ZNRF3 LRP6 UST GPR49 CTNNB1 LGR6 PMC7564666__F6 Protein Expression of Let-7a Target Genes are Altered in a LASP1-Ago2 Interaction-Dependent Manner CXCL12 AGO2 CCR7 AAG1 CCND1 PMC3940310__F4 Endogenous fatty acid metabolism in the control of hepatic gene transcription ELOVL2 RICTOR NR1C1 FASN FADS2 ELOVL5 PCK1 FADS1 PMC6362574__F1 Metabolic engineering strategies for enhancing citric acid production AOX1 MAL GLA CIT PMC7358452__F8 The in vitro effects of the poly(I:C) ENCPs developed in this study CD80 TLR3 CD163 PMC3940310__F2 Pathways for hepatic fatty acid synthesis (FASN) ELOVL2 SCD FASN FADS2 ELOVL5 ELOVL6 FADS1 PMC4442291__F2 Schematic summarization for the signaling mechanisms of the antifibrotic effects of H2S TLR4 SMAD2 SMAD4 NOX4 SIRT1 MYD88 PMC4928052__F3 Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma SMPD4 AGPS GNPAT PC PCYT2 CHKA PMC6192420__F2 Overview of the vitamin D metabolic pathway NR1i1 DBP SNAI2 PIM1 CYP2J2 CYP27A1 PMC9570242__F6 Lithium Treatment Improves Cardiac Dysfunction in Rats Deprived of Rapid Eye Movement Sleep ORAI1 SMAD2 TRPC1 AGTR1 SMAD4 TRPC3 PMC6178832__F2 Molecular features of the JAK-STAT signaling pathway STAT3 STAT2 IRF9 IL15RA STAT1 IL2RB IFNAR2 IFNAR1 STAT4 JAK1 IL23R TYK2 IL12RB1 PMC7493825__F3 NLRP6 inflammasome in health and disease TLR1 NLRP6 MUC2 MYD88 PMC7236859__F1 Proposed mechanisms of exercise cardioprotection IGF1 ERBB4 ERBB2 PMC4805534__F7 Schematic illustration of GSK3B/eIF2BE and mTORC1 signaling in AKT-induced CNS axon regeneration TSC2 TSC1 GSK3B ELF2 PTEN EIF4E PMC8698915__F4 Antibody and Protein Profiles in Glaucoma: Screening of Biomarkers and Identification of Signaling Pathways MASP1 C6 HMGB1 SERPING1 HEL-S-62p C2 C1S C1R C9 PMC8464970__F7 Ergosta-7,9(11),22-trien-3Beta-ol Attenuates Inflammatory Responses via Inhibiting MAPK/AP-1 Induced IL-6/JAK/STAT Pathways and Activating Nrf2/HO-1 Signaling in LPS-Stimulated Macrophage-like Cells TRADD TIRAP KEAP1 TLR4 RIPK1 IL6 MYD88 PMC9189780__F8 DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway HDAC1 DNTTIP1 MMP2 DUSP2 PMC9687482__F4 Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer’s Disease and Identifying Promising Drug Targets APOE APP PMC12079191__F1 Diagram of the ICG-CuET@PLGA-CS-HA (IC@PCH) nanoparticle (NP) synthesis procedure CD44 NLRP3 CS PMC8472292__F2 On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease CDC42 DKK1 APC RYK ARHA NLK CTNNB1 PMC4110625__F1 Model of ER stress-associated inflammation TRAF6 XBP1 TRAF2 IL1B PMC3615671__F2 Metabolic modulation of epigenetics in gliomas HDAC3 EGF EGFR PMC3927995__F2 NFAT proteins activate an anergy-inducing program of gene expression ZAP70 IFNG CSA2 JUN DGKA ITCH LAT TLE4 CASP3 SIRT1 PMC7703729__F8 Proposed intracellular mechanism of GRP78 and protein kinase A (PKA) signaling pathway activation by vaspin on basal and IGF-1 and gonadotropin-induced steroid synthesis in ovarian cells STAR CYP17A1 PGR NR3A2 CYP11A1 FSHR LHCGR PMC8946789__F8 The Leptin-Mediated MAPK/ERK Signaling Pathway on Collagen II Expression in Knee Cartilage of Newborn Male Mice from Obese Maternal Offspring TIMP1 SOX9 RUNX2 PMC7284105__F2 Feed-forward autocrine YAP activation ERBB3 NRG1 HBEGF EGFR PMC7284105__F1 Canonical Hippo kinase module LATS1 LATS2 PMC7926305__F5 Molecules associated with the canonical pathway (CP) ERK/MAPK signaling in the function of two stages of oocyte development RRAS CP PMC7926305__F4 Common proteins identified in the three replicates of canine in vitro oviductal cell-derived extracellular vesicles that participate in the canonical pathway (CP) ERK/MAPK signaling CRK BAD MOS PXN NFATC1 GRB2 SRC DOCK1 EIF4E PMC3336361__F4 Apoptosis pathways BAX PMC3405333__F11 P38 MAPK signaling pathway MAX ATF2 ATE1 TRAF6 TNF TRAF2 PMC3405333__F10 ERK/MAPK signaling pathway BAD MOS BRAF EIF4E PMC4887206__F6 Drosophila and vertebrate patched orthologs share a similar cis-regulatory architecture and gene regulatory strategy FANCE CTCF SAG MB GLI3 PMC7166201__F1 PTEN, a PAK1-blocker, interferes with coronavirus –induced PAK1-dependent signalling pathway leading to lung fibrosis PAK1 PTEN CCL2 ACE2 PMC4585452__F4 Schematic model of WNT signaling by the FZD receptor(s) APC RHO NLK CTNNB1 PMC5745011__F2 Pericytes of the neurovascular unit: Key functions and signaling pathways SP1 FOXO1 EGFR GRB2 MTOR SRC PMC5745011__F4 Pericytes of the neurovascular unit: Key functions and signaling pathways CDH2 SMAD1 SMAD2 DLL4 GSK3B NRP1 SMAD4 NRARP VTN VEGFA RBPJ CTNNB1 TGFBR2 PLVAP LEF1 ABCB1 PMC4810382__F2 EGFR- and ALK-signaling pathways and their respective inhibitors ALK EGFR MTOR EML4 PMC2883292__F2 Signaling through the PI-3 Kinase-Akt pathway BAD AKT3 HEL-S-28 MTOR SRC IRS1 PMC7555855__F1 Major targets of amino acids, peptides, and their analogs for the control of skin pigmentation MC1R GSK3B DCT TYRP1 CTNNB1 PMC9634190__F1 Association Between Gut Microbiota, Toll-Like Receptors, and Colorectal Cancer TBK1 TIRAP TLR9 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC9687047__F8 Quercetin Ameliorates Renal Injury and Pyroptosis in Lupus Nephritis through Inhibiting IL-33/ST2 Pathway In Vitro and In Vivo NLRP3 TLR4 IL33 IRAK1 TRAF6 IRAK4 MYD88 PMC3962777__F2 NEW STRATEGIES FOR TRIPLE NEGATIVE BREAST CANCER – DECIPHERING THE HETEROGENEITY ATR WEE2 BRCA1 INPP4B EGFR BRCA2 WEE1 ATM PTEN MTOR PMC2847412__F1 Endoplasmic reticulum stress response as a potential therapeutic target in multiple sclerosis ATF6B F11 ATF4 EIF2A XBP1 PMC9313042__F1 Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases IFNG TH IRAK1 TRAF6 IRAK4 IL18BP MYD88 PMC3594951__F1 This figure schematically shows the tyrosine kinase receptors, such as RET, EGFR, FGFR, MET, KIT, VEGFR, PDGFR, and some of their downstream effectors EGFR BRAF KIT PTEN MTOR RET PMC6562585__F4 Regulation of YAP/TAZ in epidermal cells LATS1 MOB1A MOBKL1A WBP2 LATS2 ITGB1 SRC PMC8987729__F8 Temporal Control of the WNT Signaling Pathway During Cardiac Differentiation Impacts Upon the Maturation State of Human Pluripotent Stem Cell Derived Cardiomyocytes MYL7 COX7B CACNA1C HEY2 CD36 ATP2A2 TBX5 COX6A2 HAND2 TNNI1 MYH7 MYL2 HCN1 GATA6 NKX2-5 GATA4 KCNJ2 PMC4155833__F3 Dual role of Nrf2 in cancer.Notes: As long as it is kept under homeostatic control, Nrf2 activation protects cellular components like DNA from damaging insults arising from acute/temporary oxidative and xenobiotic stress KEAP1 SFN KRAS PMC8268779__F1 Anti-Inflammatory Drugs in Patients with Ischemic Heart Disease COX1 COX2 PMC7460550__F2 Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population IFNG CCNO FOXO1 PRKCA CP PMC9252714__F9 Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death BAX FAS FADD PMC6456554__F7 Schematic representation of the outlined hypothesis LDLR ABCA1 PMC3399530__F2 Gene expression alterations in Rocky Mountain elk infected with chronic wasting disease LCP1 SDCBP ID2 CAPZA2 PCP4 SNCA NTM CS RHO NEF3 NEFH MAPK3 GNAS SCIN GDI1 RHOB GPNMB CDKN1C ERMN SNAP25 POLR2A RDX HEL-S-44 PMC4514860__F1 Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway BAMBI SOST ROCK2 APC SMAD4 SKP1 ARHA PMC2695762__F2 Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity TLR1 BCL10 TLR3 TLR4 TLR9 TLR8 NOD2 TLR5 TLR7 CARD9 PMC6671812__F12 Proposed model of IL-18-mediated microglia/astrocyte interaction in the spinal cord TLR4 BDNF IL18BP PMC4471869__F3 Interleukin-33 in tissue homeostasis, injury and inflammation TSLP IL33 PMC4514860__F2 Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway BAMBI SOST SKP1 PMC9396350__F6 Erythropoietin mediates re-programming of endotoxin-tolerant macrophages through PI3K/AKT signaling and protects mice against secondary infection VEGFC EPOR TLR4 IRAK3 EPO MARCO WDR5 PMC5617803__F1 The pikromycin (Pik) biosynthetic pathway tmp_locus_29 HEL-S-5 CP PMC5832166__F7 TGFB1 signaling in hMSC differentiation PLAT SOS2 HEL70 EGR2 KRAS MEF2D FGF2 PMC7449921__F8 Working model of how MAD2 downregulation promotes asymmetric division and reduces tumor growth and invasion in MKN45 cell line SNAI2 CXCR4 PMC7351433__F1 Simplified scheme of cellular pathway and the targets of MTX MTHFD1 RFC1 DHFR GGH TYMS ABCG2 HEL-S-70p FPGS PMC7944129__F6 Regulatory network of different pathways VWF FH CPB2 HEL-S-62p CR2 CS OTP FRY C2 OMP CD9 F10 C9 PC A2M DAP LYN PMC2630276__F7 Model for the role of Hedgehog in the recovery of the BMP4-dependent stress erythropoiesis pathway in the spleen BMP4 DHH IHH PMC6433939__F1 Schematic diagram shows the regulatory non-coding RNAs in NAFLD disease development and progression ACTA2 NR1C1 NR2A1 MTTP PER2 KLF6 SMAD2 PTEN PLP2 PMC7797046__F5 Schematic showing the biosynthetic pathway of OHyW in wild type cancer cells (blue area) and taxol resistant strains (red area) TYW5 TYW3 TYW1 PMC152905__F6 Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line RAD18 REV1 XRCC3 PMC9350527__F1 Gut Microbiome-Linked Metabolites in the Pathobiology of Major Depression With or Without Anxiety—A Role for Bile Acids CYP8B1 CYP7A1 GCA CYP7B1 CYP27A1 PMC2981456__F1 The estrogen biosynthesis pathway HSD3B1 HSD17B1 CYP1B1 PMC4583600__F2 Cell biology functions and pathways of the genes involved in melanoma susceptibility OGT TINF2 TERF2 FOXK1 ASXL1 ACD TERT TERF1 YY1 ASXL2 BARD1 TERF2IP BRCA1 HAT1 FOXK2 MDM2 CCND1 POT1 CDK4 PMC317073__F7 Regulation of TNF-R1signaling pathways during apoptosis TRADD TRAF2 FADD PMC8463866__F1 Production and Function of Endogenous Interleukin-10 in Intestinal Epithelial Cells and Gut Homeostasis FAS CASP8 CASP3 TNF PMC3315606__F1 Roles for prions and protein-only inheritance in cancer BAX TNF CCND1 MMP11 PMC7463967__F4 Network of known interactions between RTKs and the Hippo pathway STAT3 EGF GLS ITCH ERBB4 EGFR SOX2 HIF1A RHO IRS1 MERTK LATS1 EPHB2 LATS2 ALK AJUBA RET PMC6139616__F1 Hepatic lipid metabolic pathways investigated in this study ACLY TG UGT1A3 HMGCR FASN DROSHA CPT1A PMC7033839__F1 Proposed mechanism of statins, colchicine, and aspirin on the reduction of radiation‐associated cardiovascular disease (RACVD) IL13 IL4 IL6 RHO PMC11172987__F2 Host Cell Death and Modulation of Immune Response against Mycobacterium tuberculosis Infection STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC3344210__F4 The effects of curcumin on the TNFA receptor and its downstream signaling pathway SOS1 IL18 OCEL1 TNF TRAF2 PMC7463967__F1 Illustration of the Hippo pathway and its regulation in mammalian cells LATS1 LPA LATS2 EGFR PMC4410181__F2 Control of regulatory T cell lineage commitment and maintenance SP1 BCL10 FOXP3 PMC9795026__F1 Toolkit for plant lipid engineering: Surveying the efficacies of lipogenic factors for accumulating specialty lipids LPA EPX FAS PC PMC6494966__F1 Schematic depiction of processes and pathways involved in iron homeostasis and regulation in the brain FBXL5 LDLR APP PMC5239436__F1 Autophagy complexes cell death by necroptosis RIPK3 BAX TRADD MLKL RIPK1 TRAF2 FADD PMC6091082__F3 The applied conditions on the expression of central metabolism genes HEL107 RPE SDHA ART1 FAS AMT PML GIP TNLG7C PMC5992122__F1 Universal Pathway for the Biosynthesis of Coenzyme A and Associated DiseasesIn green are indicated genes encoding either cytosolic or mitochondrial isoforms PPCS PPCDC PMC8572801__F7 Mucin 20 modulates proteasome capacity through c‐Met signalling to increase carfilzomib sensitivity in mantle cell lymphoma HGF MUC20 POMP PMC5204264__F2 Proteome complexity and the forces that drive proteome imbalance MAF POLI MYC NRF1 ELF3 PMC5968632__F2 Pathways significantly enriched for: (A) Loci associated with the vertical cup-disc ratio, cup area and intraocular pressure (P-value <7.0 × 10-6 in the GWAS) THBS1 RFX2 DVL3 NOTCH3 MDFI PMC8471715__F2 Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction LPO NRF1 MYD88 PMC8293073__F5 BMP Signaling in Osteoclast Regulation SMAD1 DKFZp781O1323 SMAD4 TRAF6 PMC6693242__F1 The autophagy pathways in endothelial cells ALG14 PMC12245983__F5 PI3K/Akt/mTOR signalling pathway is activated upon binding of growth factor to receptor tyrosine kinase (RTK), which results in autophosphorylation of tyrosine residues and recruits phosphatidyl-inositol-3-kinase (PI3K) to cell membrane PTEN MDM2 MTOR PMC12245983__F4 Notch signalling pathway upon activation, Notch receptors release signal-transducing Notch intracellular domain (NICD), which moves into the nucleus where it interacts with CSL nuclear proteins, forming CSL-NICD transcriptional complex HES1 NOTCH1 PMC11994588__F3 Liquid-Liquid Phase Separation (LLPS) in Cellular Signal Transduction Pathways APC AXIN1 MTOR PMC8570367__F1 Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment GLS ME1 HEL-S-26 PMC6586788__F1 Hypoxia and aging COCH MDM2 MTOR PMC6820556__F6 Model summarizing the ABeta-induced actin cytoskeletal abnormalities via SHIP2-PI(3,4)P2-ARAP3-RhoA signaling pathway PI3 GSK3B ARHA PMC10915940__F1 Canonical signaling pathway of interferon-gamma STAT1 IFNGR2 IFNGR1 JAK1 PMC12245983__F7 Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models TH MTOR HES1 CTNNB1 PMC8505556__F2 Tumour suppressor functions of BAP1, Merlin and p16INK4a/p14ARF proteins LATS1 BAX RAD52 LATS2 BRCA1 PRC1 BRCA2 BAP1 MYC CDK4 PMC12245983__F6 Hedgehog pathway is mediated by ligand HH, upon binding to PTCH the SMO inhibition is weakened, allowing its translocation to plasma membrane leading to HH pathway activation SUFU SMO GLI3 PMC7403459__F1 Two primary pathways produce ceramides in cells: (a) de novo synthesis (b) re-acylation of sphingosine (salvage pathway) CERS3 CERS5 CERS2 PMC9539794__F6 Triptolide in the treatment of systemic lupus erythematosus - regulatory effects on miR-146a in B cell TLR7 signaling pathway in mice IRAK1 TLR7 MYD88 PMC3884200__F5 Effects of CYP2S1 depletion on mTOR signaling STK11 CAB39 DDIT4 ULK1 PIK3R1 BRAF PTEN HIF1A MTOR STRADA PDPK1 PRKCA AKT1S1 ULK2 RPTOR RPS6 EIF4EBP1 VEGFA TNF IRS1 EIF4E RHEB TSC2 RICTOR TSC1 IGF1 IKBKB PMC7071019__F2 Cellular response: APCs and T-lymphocytes TH APC PMC12245885__F2 Major mechanisms of platelet aggregation VWF COX1 PMC4698632__F8 Telomerase reverse transcriptase acts in a feedback loop with NFKB pathway to regulate macrophage polarization in alcoholic liver disease CSA2 NOS2 TLR4 IRAK1 TERT TRAF6 TNF IRAK4 IL1B MYD88 PMC6070353__F2 Oncogenic Signaling Pathways in The Cancer Genome Atlas FLT3 RAF1 SOS1 KEAP1 SMAD2 GSK3B SMAD4 NTRK3 MYC AMER1 FGFR2 RB1 CDKN2A FBXW7 CDK6 CSNK1E CCNE1 ALK NF1 NCOR1 ERRFI1 FGFR1 MXD3 RIT1 MAPK1 TAOK1 TAOK2 MXD1 MNT APC LRP5 LRP6 NTRK2 PCDHJ YAP1 RHEB ERBB3 TSC2 RICTOR TSC1 CDKN1A PSEN2 AXIN1 SFRP5 MAX DKK4 STK11 STK4 TGFBR1 TGFBR2 MGA MDM4 ERF MAML3 INPP4B MLX CHEK2 JAG2 NF2 MXI1 CRB1 ERBB4 KDM5A KIT PPP2R1A TCF7L1 RAC1 AXIN2 SFRP1 ARAF CBL ARRDC1 WWC1 PDGFRA TAOK3 CREBBP ERBB2 EP300 CRB2 DKK1 FGFR4 MYCL MDM2 ROS1 ACVR2A MXD4 CSNK1D TLE4 SFRP4 CDKN1B CDK2 FAT1 ZNRF3 CDKN1C RET EGFR BRAF IGF1R PTEN MTOR DCHS1 CTNNB1 TLE2 LATS1 MOB1A TEAD2 ACVR1B ATM DKK2 DNER MLXIP CDK4 RPTOR SPEN TLE3 PTPN11 DKK3 NCOR2 RNF43 NTRK1 FGFR3 RPS6KA3 MAP2K1 MAP2K2 WIF1 PMC7981362__F1 Insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer’s disease IDE MTOR IRS1 PMC8945030__F1 Gene Variants Involved in Nonsense-Mediated mRNA Decay Suggest a Role in Autism Spectrum Disorder UPF2 FAS SMG1 SMG9 XRN1 PABPC1 UPF3A SGA56M SMG8 PNRC2 DHX34 NBAS RUVBL2 CASC3 RNPS1 PMC7981362__F2 Insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer’s disease TSC2 TSC1 MTOR IRS1 PMC6476855__F1 Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation EGF MTOR SRC BDNF MYD88 PMC1088370__F1 Topologies of the three networks CDC20 APC MB PMC4150610__F2 Interferon-inducible effector mechanisms in cell-autonomous immunity TBK1 NOS2 LRRK2 HEL-S-62p SNAPIN GBP7 GBP1 ATG5 GBP2 ATP7A PMC4113681__F1 Representative regulators of the Sprouty cellular content at transcriptional and post-translational level irrespective of the Sprouty isoform and cell type CDC42 CRK CBL SIAH2 CS ARHA GRB2 MYC RAC1 CTNNB1 PMC4113681__F2 The Sprouty-mediated regulation of cell proliferation, differentiation, and survival irrespective of the Sprouty isoform and cell type CRK BAD CBL GSK3B PTEN GRB2 MYC PMC11185840__F4 Sphingolipids and complement components signaling in glioblastoma STAT3 S1PR1 SPNS2 NLRP3 PPIL1 CTSL CXCR4 BCL2L13 PMC11185840__F3 Activation of the complement system and its functions C6 C7 ATG16L1 NLRP3 HEL-S-130P HEL-S-62p C2 CTSL C9 CD46 MTOR PMC11185840__F2 Sphingolipid metabolic pathway CERK tmp_locus_29 UGT8 PMC9293722__F6 Retinoic acid can improve autophagy through depression of the PI3K-Akt-mTOR signaling pathway via RARA to restore spermatogenesis in cryptorchid infertile rats STRA8 TH RARA SYCP3 PMC12130998__F7 Supposed mechanism on the dual role of pB318L in viral replication STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 KPNA1 PMC3175563__F6 Proposed mechanism of mechanical stress–induced activation of EGFR pathway in murine tracheal epithelial cells EGF HBEGF TGFA EGFR PMC8572027__F2 Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures NLRP3 MAF TRAF6 IL1B PMC5486373__F1 MiRNAs involved in the regulation of autophagy-related signaling pathways DUSP5 APRT STAT3 STK11 ULK1 RPS6KB2 PTEN IGF1R FUNDC1 TIGAR MTOR MLSN2 UCP2 TGFBR2 CAMKK2 RPTOR HMGB1 TFAP2A DUSP4 BNIP3L DRAM1 RHEB TSC2 RICTOR TSC1 CDKN1A FOXO3A CDKN1B CDK2 SIRT1 HMGB2 PMC2949025__F2 Correlations (Spearman) of biomass growth (biom) and lignin levels with transcript abundance of specific monolignol biosynthetic genes in a interspecific pseudo-backcross pedigree of Populus (family 52-124) CAD PMC7565022__F1 Hedgehog (HH) signaling pathway SUFU SMO GAS1 GLI3 PMC7565022__F4 Protein arginine methyl transferase (PRMT)-mediated modulation of glioma-associated oncogene (GLI) 1 or GLI2 activity PRMT1 PRMT7 ITCH SUFU NUMB GAS1 PMC3561376__F6 Whole Genome Gene Expression Analysis Reveals Casiopeína-Induced Apoptosis Pathways TRADD APAF1 TRAF2 FADD PMC3561376__F5 Whole Genome Gene Expression Analysis Reveals Casiopeína-Induced Apoptosis Pathways IL15 UGCG CSF1 GADD45G IL2RA TERT MYC TACSTD2 CSNK2B STAT1 MOAP1 SNAPC4 STAT5B GADD45B IL2 FOXP3 BAX CASP8 ADM MMP9 SATB1 PUM1 CDKN1A CASP3 BCL2 IFNB1 TNFSF10 FADD PMC4514086__F3 Cytosolic RNA and DNA-induced type I IFN signaling pathway and its regulators NMI TBK1 CGAS TRIM32 TRIM56 MAVS GSK3B IRF3 IFI16 IRF7 TRAF3 TRAF6 TRIM21 NLRX1 RIGI USP3 ATG12 TRIM25 NLRC3 DDX41 ATG5 TRAF2 PMC4644426__F9 Syncytin-1 alterations triggered placental trophoblast cell cycle changes CDC2 CDK4 PMC4299200__F1 De novo and salvage pathway synthesis of dTMP in the nucleus MTHFD1 DHFR SHMT1 TYMS MTR PMC6814454__F2 Substrates of PD enzymes identified by proteomics.(A) The PINK1-parkin mitophagy pathway PINK1 GDI1 LRRK2 PMC4064951__F2 Resistance to BRAF inhibitors: intrinsic and extrinsic mechanisms.Notes: Multiple different mechanisms have been described in resistance to BRAF inhibitors PI3 EGFR NRAS PTEN IGF1R MTOR CDK4 PMC3410756__F1 Folate mediated one-carbon cycle DHFR MTRR TYMS PMC4973992__F6 High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model GRM3 GRM4 GRM8 GLS GRM6 SLC38A1 PICK1 GRM2 PMC3723115__F2 Canonical TGFB signaling within distinct cell types located in tumor microenvironments SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC8717053__F1 Antiviral effect of antineoplastic agents inhibiting mTOR/PI3K signaling pathway in SARS-CoV-2 infection in cancer patients PTEN MTOR ACE2 PMC4452069__F1 PI3K/Akt/mTOR signaling cascade PTEN MTOR PMC8465097__F5 Differences in Acid Stress Response of Lacticaseibacillus paracasei Zhang Cultured from Solid-State Fermentation and Liquid-State Fermentation MAX MAEA MALL GC HELB GLA PMC9361020__F1 Endoplasmic reticulum stress in innate immune cells - a significant contribution to non-alcoholic fatty liver disease ATF4 EIF2A XBP1 PMC8536552__F7 Heat stress inhibits TLR4-NFKB and TLR4-TBK1 signaling pathways in broilers infected with Salmonella Typhimurium TBK1 NLRP3 TLR4 IRF3 IL1B PMC5969225__F3 Hh–Gli signalling in myofibroblasts PTCH1 DHH SHH IHH SMO PMC8343457__F1 Cerebrospinal fluid metabolomics: detection of neuroinflammation in human central nervous system disease ASL KYNU OTC PMC4410310__F3 Gallus Gallus retinol metabolic pathway from KEGG LRAT RPE65 DHRS4 PNPLA4 UGT2B7 PMC2822520__F7 A working model for endosomal transport involving CLC-5 and KIF3B interaction in polarized cells KIF3A KIF3B PMC8226833__F3 Resveratrol Production in Yeast Hosts: Current Status and Perspectives HEL107 FH STS PMC6650384__F2 Changes in placental signaling in IUGR IGF1 IGF1R EIF2A PMC5708160__F1 Strategies for Comparing Metabolic Profiles: Implications for the Inference of Biochemical Mechanisms from Metabolomics Data APRT GMPR ADA PMC3160197__F1 Crucial role of EGF signalling augments healthy lifespan in worms EGF EGFR MTOR PMC3882527__F5 Ingenuity pathway analysis (IPA)-identified top networks affected by Cd-induced oxidation of proteins HEL-S-43 HEL113 FLNB HEL32 tmp_locus_29 HEL-S-49 ATP1A1 RHO CAP1 HEL-S-15 PMC5804490__F3 Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an exploratory study ARHH CD79A PLEKHA2 BLNK PRKCH HDAC1 TPR NAPEPLD FYN PRKCA APP CAMK4 LPP CP RCAN3 PMC4896164__F2 Main pathways regulated by the BCR-ABL1 protein GATA2 CSA2 RAF1 CRKL MDM2 GRB2 PMC5444348__F1 The IFN-1 > BID > ROS pathway connects DNA damage with hyper-proliferation and malfunction of haematopoietic stem/progenitor cells (HSPCs) MTCH2 ATR CGAS ATM IRF3 PMC4438523__F3 “Actin Cytoskeleton Signaling” pathway highlighting differentially expressed genes of birds affected with Wooden Breast myopathy ABI2 EGF TRIO PXN GNG12 CD14 ARHA FLNA DOCK1 HEL114 CRK F2R RP2 GRB2 BAIAP2 LBP PMC9405349__F7 GLUT3 Promotes Epithelial–Mesenchymal Transition via TGFB/JNK/ATF2 Signaling Pathway in Colorectal Cancer Cells CDH2 ATF2 PMC6785638__F5 Calcium signaling pathway is overrepresented in the specific differentially expressed genes altered by alfalfa intervention during the preweaning period NOS2 HRC FAM20C STAC PPARGC1A PRKCB RORA PMC7867281__F1 Principal functional interactions between lncRNA HOTAIR and different microRNAs STAT3 PCDH10 CCL18 AXL ABL2 JAK3 MTOR CCL2 GPC5 CDK6 HLA-G DACH1 NOTCH3 CDK4 PMC9453976__F3 Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process MAF TRAF6 SIRT1 IL1B PMC7826734__F1 Role of VEGF signaling in OSCC STAT3 EGF CCL4 PMC11547105__F5 Comparative Metabolomics to Unravel the Biochemical Mechanism Associated with Rancidity in Pearl Millet (Pennisetum glaucum L.) FAS PC PMC6037329__F2 Cholesterol and Bile Acid -Mediated Regulation of Autophagy in Fatty Liver Diseases and Atherosclerosis TG ABCG1 ABCG8 ABCG5 CYP7A1 LDLR ABCA1 PMC9361020__F3 Endoplasmic reticulum stress in innate immune cells - a significant contribution to non-alcoholic fatty liver disease TRAF6 IL1B PMC2223843__F2 TLR3 signaling pathways TLR3 IRF3 PMC4887998__F7 Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis STAT1 TLR3 MSC PMC6880379__F3 The Atm-Aim2 axis in neuroinflammation and neurodegeneration AIM2 ATM IL1B PMC8714844__F3 Recent Progress in Lymphangioma TSC2 EIF4E PMC5951909__F8 NDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors NDRG3 VHL PMC7352956__F3 Regulation of the Hippo/YAP signaling pathway in non-small-cell lung cancer (NSCLC) LATS1 EGF LATS2 EGFR PTCH1 SMO NF2 CTNNB1 PMC7650612__F2 Influence diagram of the molecular interactions implemented in the model ERBB3 EGF ERBB4 HRG ERBB2 GRB2 PMC6109711__F3 cAMP/PKA network HMGB1 PANX2 CREM PPP1R10 CTNNB1 P2RY14 NR2A1 CDK5 HIPK2 HPGD SIX3 SNCG EP300 AMHR2 SOX5 SMARCA4 PMC3127162__F8 E3 ubiquitin ligase-dependent and E3 ligase-independent roles of Rad18 in tolerance of bulky DNA lesions (left) and replication-associated DSB (right) RAD18 FANCD2 RAD51C POLN PMC7459983__F3 Schematic description of genetic abnormalities (mutations or upregulation) associated with secondary off-target resistance to FLT3 inhibitors STAG2 FLT3 TET2 AXL PIM1 BRAF ASXL1 PTPN11 MTOR KRAS CBL NRAS HEL-S-26 PMC8034476__F2 Mechanism and regulatory axis of PTHR1 in osteosarcoma DKK1 VMP1 HAS2 LEF1 PMC8779408__F2 Nek2 Kinase Signaling in Malaria, Bone, Immune and Kidney Disorders to Metastatic Cancers and Drug Resistance: Progress on Nek2 Inhibitor Development CIP2A CEP68 NEK2 PLK1 PMC5010489__F2 Molecular mechanisms of innate immune inhibition by non-segmented negative-sense RNA viruses STAT1 MAVS STAT2 IFNAR2 IFNAR1 TANK IRF3 IRF7 TRAF3 JAK1 TYK2 PMC6307528__F5 Crosstalk between the Rho kinase and BMP-2 signaling pathways SMAD1 BMP2 ARHA RHO PMC8217435__F1 Inhibition of the IFN Response by Bluetongue Virus: The Story So Far TBK1 IFNGR1 IFNLR1 MAVS STAT2 IRF9 IFIT1 IRF3 IRF7 STAT1 IFNGR2 TLR3 IFNAR2 IFNAR1 JAK1 TYK2 PMC2585009__F7 HIV-1 Activates Macrophages Independent of Toll-Like Receptors TBK1 TIRAP MAL TANK IRAK1 IRF3 TNF TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TICAM1 TLR4 PMC8103215__F4 Beta-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NFKB Signal Pathway: In Silico and In Vivo FRY MCU DAP CLPS PMC7838888__F1 Representative long non-coding RNAs (lncRNAs) in diffuse large B-cell lymphoma (DLBCL) BUD13 MYC PMC8217435__F3 Inhibition of the IFN Response by Bluetongue Virus: The Story So Far TBK1 MAVS TLR3 IRF3 IRF7 TRAF3 MYD88 PMC2585009__F4 HIV-1 Activates Macrophages Independent of Toll-Like Receptors TRADD MAP3K12 MAPKAPK3 MAP3K11 ATF2 MAPK8 MINK1 TNFRSF6B MAPK3 MAPK14 STAT1 ADRA2A MAPK8IP1 FGFR1 MAP2K3 HEL2 DUSP7 MAPK1 SP1 MAPKAPK5 TNF PAK1 MAPK7 RGS4 MAP2K2 GRB2 TRAF2 PMC8217435__F4 Inhibition of the IFN Response by Bluetongue Virus: The Story So Far TBK1 IFNGR1 IFNLR1 MAVS STAT2 IRF9 IRF3 IRF7 STAT1 IFNGR2 IFNAR2 IFNAR1 JAK1 TYK2 PMC2364238__F1 SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer TF SMAD2 SMAD6 SMAD4 CP PMC2895628__F5 Mode of miRNAs that regulate adipogenesis by modulating the canonical Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 PMC6266631__F6 KDM5A function and its expression control in proliferating NPC and differentiating astrocyte STAT3 CNTF EGF GFAP KDM5A FGF2 PMC7753287__F2 Diverse roles of long non‐coding RNAs in viral diseases SUZ12 EED CSF1 EZH2 TNF CXCL10 BCL2L11 MYD88 COX2 IFNAR2 TLR4 RELA IFNAR1 TLR8 TLR7 TYK2 PMC12222062__F8 Oxytropis falcata bunge extract combined with black soybean oil ameliorates DNCB-induced atopic dermatitis-like skin inflammation HDAC3 CCL27 IL4 PMC4000654__F1 Physiological and physiopathological UPR activated pathways in B cells ATF4 EIF2A XBP1 PMC9476852__F6 Chinese herbal formula shen-ling-bai-zhu-san to treat chronic gastritis: Clinical evidence and potential mechanisms STAT3 SYK BAD HGF AXL EGFR LIF HRG RBL2 PTEN CD19 SHE EIF4E POR TSC2 TSC1 BRCA1 BCR NF1 CD37 RXRA RAE1 SI MDM2 PMC9607181__F1 Important Hormones Regulating Lipid Metabolism FASN ELOVL6 PMC7795602__F1 Regulatory functions of Mediator complex in biotic and abiotic stress responses CDK8 MED12 MED13 PMC9281252__F4 Molecular perspective on targeted therapy in breast cancer: a review of current status RHEB TSC2 TSC1 PTEN IGF1R GRB2 PMC5438978__F1 Regulation of IL-1/18 production and current IL-1/18 antagonists NLRP3 PSTPIP1 IL18BP PMC4997237__F14 Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures RPL27A RPL35 RPL18 RPS2 RPLP0 EIF5 ELF4 RPL15 EIF3F RPL27 ATM RPL4 GRB2 EIF2A ELF5 ELF3 PMC8000424__F5 Effective graph reveals redundancy, canalization, and control pathways in biochemical regulation and signaling FOXA1 PRB2 BAD SGK1 MCL1 PBX1 PTEN MYC CCND2 FOXO3A PRB3 CDK2 BCL2 PMC4673177__F8 Cerebral endothelial cell function by TGFB in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition CDH2 VWF PIGF SNAI1 CLDN5 PMC3734905__F2 Germline syndromes associated with the Ras signaling pathway.Schematic diagram showing the GM-CSF receptor spanning the phospholipid bilayer CBL NF1 GRB2 PMC7943547__F1 Role model of intracellular HYOU1 in tumor development HYOU1 ATF4 EIF2A PMC3241690__F7 Crosstalk between Nuclear Factor I-C and Transforming Growth FactorB1 Signaling Regulates Odontoblast Differentiation and Homeostasis SMURF1 SMAD2 SMAD4 SMURF2 PMC3967109__F2 Target gene set within Alzheimer’s disease environmental network TMED10 APH1B MMP17 PITX3 METTL2B PMC9133606__F3 Phytochemicals in Skin Photoprotection via Regulation of Nrf2 KEAP1 NQO1 MMP3 MMP9 PMC9239764__F9 ARL4C Regulates the Progression of Clear Cell Renal Cell Carcinoma by Affecting the Wnt/Beta-Catenin Signaling Pathway CDH2 CTNNB1 PMC9133606__F2 Phytochemicals in Skin Photoprotection via Regulation of Nrf2 NQO1 PC IL6 PMC9602067__F4 Novel De Novo NFKBIA Missense Mutation Associated to Ectodermal Dysplasia with Dysgammaglobulinemia CD40 BCR EDAR PMC8740228__F4 Comparative Proteomic Profiling Identifies Reciprocal Expression of Mitochondrial Proteins Between White and Gray Matter Lesions From Multiple Sclerosis Brains NAPA CDC42 ST13 TNC NAPB ARHG VAMP2 ANK2 APC RHO RAC1 SET AP2M1 CRK HEL-S-47e RALA GRAP HEL-S-80p CLU AP2A1 ESD AP2A2 PSAP PFKM PMC8994495__F6 Network diagram of “component-target-pathway” ACHE BAX ENG PGR EGFR APP PMC9641012__F7 Quantitative proteomic analysis reveals the molecular mechanism of the Yesso scallop (Patinopecten yessoensis) in response to Polydora infection PAK1 BIN1 LPP M6PR PMC11540618__F7 Lipid metabolic profiling and diagnostic model development for hyperlipidemic acute pancreatitis WAS PC PMC6627153__F6 PCOS–disease subnetwork 28 BBS2 JUN DNAJB1 CREB5 NFATC2 HNRNPD MCL1 MAPK9 BBS1 TOX4 PPP1R10 HUWE1 STUB1 PTBP1 HEL-S-80p BBS7 MYH9 HSPA4 BBIP1 TTC8 ATF7 MDM2 PMC6627153__F3 PCOS–disease subnetwork 8 NR1i1 NUF2 KNTC2 ZWINT NCOA1 SKP2 SPC25 KNL1 RUNX1 BRCA1 CDKN1B SPC24 CREBBP NSL1 RPAP3 URI1 PMC6627153__F2 PCOS–disease subnetwork 1 RPS16 RPS26 RPS6 RPS3A RPS13 RPS5 RPS2 RPS25 VCAM1 RPS9 RPS18 PMC6627153__F4 PCOS–disease subnetwork 26 HLA-E LILRB4 HLA-C HLA-A PMC4734217__F1 Pim-1 kinase as cancer drug target: An update SOCS1 STAT3 TSC2 BAD PIM1 RELA BCL2 NFATC1 SOCS3 CBX3 MYC EIF4E PMC7996988__F8 Induction of interferonB and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cells STAT1 IFNAR2 IRF9 IFNAR1 PMC3218720__F2 Receptors that sense danger signals released from neighboring injured retinal pigment epithelial (RPE) cells HMGB1 TLR4 TLR9 IL1B PMC3393662__F8 Shp2 Activates Fyn and Ras to Regulate RBL-2H3 Mast Cell Activation following FcERI Aggregation SYK FYN LAT LYN GAB2 PMC514952__F1 Mechanism of endocytic downregulation of RTKs TSG101 EEA1 PMC2841320__F6 ZIP4 Regulates Pancreatic Cancer Cell Growth by Activating IL-6/STAT3 Pathway via Zinc Finger Transcription Factor CREB STAT3 PC CCND1 PMC6003649__F10 Signalling pathways involved in the intervention effects of PZC, PZD and PZE on TIF TGFBR2 SMAD2 APC AXIN1 LRP5 LRP6 CTNNB1 PMC4630171__F12 Proposed model LRP5 WNT4 CCND1 LEF1 CTNNB1 PMC9516113__F1 Defining and targeting patterns of T cell dysfunction in inborn errors of immunity ZAP70 CD80 MTOR PMC11526956__F1 Distribution of dNdS values for genes encoding proteins involved in upstream and downstream NFLs across various signaling networks LATS1 SOCS1 DKK3 LATS2 AXIN2 CTNNB1 PMC3388714__F2 Layers of DC-mediated tolerance CD80 IL10 TNF PMC11814332__F9 Schematic depicting the role of CerS6 in ceramide metabolism and innate immune responses TBK1 CGAS CERS6 PMC8345475__F1 Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics SUFU SHH SMO PMC3423345__F2 Early Second Trimester Maternal Plasma Choline and Betaine Are Related to Measures of Early Cognitive Development in Term Infants HEL-S-182mP DHFR CHDH PMC6423516__F2 Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor is the Undercover Boss ATG16L1 ATG12 ULK1 TFEB LYN ATG5 PMC8345475__F2 Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics IRF6 IRF4 PMC9692235__F6 Transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation FLT3 HDAC1 HES4 TLE3 TLE4 FOXC1 BCL2 PTEN MYC CYLD HES1 TLX1 PMC3288319__F4 Phytoestrogens on ECs and VSMCs GC ARHA PMC6423516__F3 Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor is the Undercover Boss STK11 PINK1 PER2 ULK1 SIRT4 CRY1 SIRT5 PGC SIRT3 FXR1 TFEB SIRT1 CREB1 PMC8146591__F2 Glutathione S-Transferases in Cancer HEL-S-22 MTOR TRAF2 PMC9692235__F2 Transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation CHAC1 BRCA1 ERBB2 MYC CCND1 FOXG1 PMC7900568__F1 cGAS-STING pathway and type-I IFN signaling TBK1 STAT1 CGAS IFNAR2 IFNAR1 IRF3 JAK1 TYK2 PMC3507808__F1 Metabolites and their metabolic pathway networks measured by the Arg/Thiol Redox Metabolomics Assay ASL HEL-S-61p CIT PMC3863464__F6 Putative CA-mediated inhibitory pathway of inflammatory signaling events TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC6213474__F2 Sonic Hedgehog (SHH) molecule or SHH secreted on extracellular vesicles (EVs) mediated functional improvement of endothelial progenitor cells (EPCs) SUFU SHH ARHA PMC9569554__F4 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair EPHB4 TSC2 MSC EPO MTOR PMC12188669__F2 YOD1 in regulating multiple cellular signaling pathways YOD1 NEDD4 ITCH SMAD2 TRAF6 PMC6213474__F1 Canonical and Non-Canonical Sonic hedgehog (SHH) signaling pathway in endothelial progenitor cells (EPCs) and endothelial cells (ECs) SUFU PTCH1 SHH MMP2 SMO ARHA PMC9569554__F3 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair EPOR EPO RUNX2 FGF23 PMC4323349__F1 Transgenic Mouse Models for Alcohol Metabolism, Toxicity and Cancer ALDH2 CYP2E1 GCLM GCLC PMC9569554__F5 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair SMAD1 DKFZp781O1323 BMP2 LRP5 MSC LRP6 TNF CTNNB1 PMC12188669__F6 Disease signaling by YOD1: potential implications for therapeutic strategies CDC2 YOD1 NLRP3 ITCH TUG1 CTNNB1 PMC12188669__F5 Roles of YOD1 in Diseases YOD1 RIPK2 NEDD4 INHA ITCH MYH9 NOD2 PML YY1 MDM2 PMC9569554__F2 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair NOS2 ADAMTS4 SOX9 DLL4 NRP1 NRP2 MMP3 TWIST2 PTGS2 MMP9 RUNX2 PMC6367275__F2 Schematic and simplified representation of the several components of the IGF-1/PI3K/AKT/mTOR pathway discussed in this review BAD IGF1 IGF1R GRB2 DEPTOR PMC7536068__F1 Schematic depicting an overview of the autophagy pathway and mechanisms used to manipulate autophagy ATG3 ATG12 ATG5 PMC5928262__F1 Ang/Tie pathway regulation of vascular stability ASB1 FOXO1 TRPC1 ARHA RHO SRC RAC1 PMC2735125__F7 HP1 Proteins Form Distinct Complexes and Mediate Heterochromatic Gene Silencing by Non-Overlapping Mechanisms CHP2 AGO1 CIRSR CHP1 PMC2408433__F1 Glucose transport regulation by the Akt/TSC pathway RHEB TSC2 TSC1 MTOR PMC7283559__F1 C-type lectin receptor signaling in TB and HIV MRC1 APC MYD88 PMC7112240__F1 Drosophila-associated bacteria differentially shape the nutritional requirements of their host during juvenile growth AIP PMC8699653__F2 Methylation Markers in Cutaneous Melanoma: Unravelling the Potential Utility of Their Tracking by Liquid Biopsy ATR BAD ATM PTEN MGMT PMC3909204__F1 EGFR and FGFR Pathways Have Distinct Roles in Drosophila Mushroom Body Development and Ethanol-Induced Behavior EGFR RHO PMC8446437__F2 Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers via Dormancy Regulation IFNG IDO1 AHR PMC8222670__F4 Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition EGF COX2 GSK3B ZEB2 ARHA CTNNB1 PMC4820400__F2 Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease IDE BACE1 MMP9 PMC4275944__F5 A schematic linking the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation to status epilepticus (SE) pathogenesis NLRP3 TLR4 IL1B PMC6412771__F2 De novo synthesis of NAD(P) from tryptophan, nicotinamide and nicotinic acid HEL-S-90n KYNU KMO NAMPT AFMID NADSYN1 PMC7022881__F1 Two signaling pathways that respond to extracellular glucose in Saccharomyces cerevisiae TPK1 GBP1 GBP2 PMC6279876__F4 Schematic model of HPV-driven carcinogenesis CDK6 E2F3 SIRT1 CDK4 PMC9634088__F2 Immune defenses of the mammary gland epithelium of dairy ruminants TLR1 TIRAP TLR3 CD36 TLR4 NOD2 IRF3 NOD1 TRAF3 TRAF6 IL1B MYD88 PMC6557761__F5 Evaluations on Substrates of FBXL Family E3s(A and B) Known (red edge) and predicted (gray edge) ESIs for FBXLs CAMK1 RAN MAPKAPK3 POLR2K PRKCZ CCNA2 POP1 GTF2F1 CTBP2 HSPD1 CCNE1 TOB1 E2F4 FBXL12 CRY2 CSNK2A1 HEL-S-1 MDM2 HNRNPK TOPBP1 NBN DAB2IP DOCK1 TAF15 UBE2T USE1 XRCC5 DDB1 CDKN1A SUFU CDK2 MCM6 FBXL8 FBXL6 BHLHE41 HSD17B4 SLC3A2 FBXL17 FBXW8 NUP214 RASSF1 ANAPC7 FBXW11 NUDT21 SMN1 EMG1 CTNNB1 CKS1B SNRPB2 NFKBIE POLR2A TFDP2 CDC2 CD81 DDX5 SNRPA CRY1 GTF2E1 RBL2 RAC1 FBXL15 FZR1 SMURF1 PPP2R2A CASP3 PIAS1 NFKBIA CREBBP FBXL3 EP300 DNAJC10 PMC10302777__F2 Betaine as a Functional Ingredient: Metabolism, Health-Promoting Attributes, Food Sources, Applications and Analysis Methods HEL-S-61p PMC3747540__F1 Emerging signaling pathways in hepatocellular carcinoma LATS1 LATS2 HHIP TLR4 ARID2 SMO NF2 PMC6627996__F3 TLR4 signal pathway in oxidative stress TIRAP TLR4 CD14 IRAK4 MYD88 PMC3434202__F1 Suppression of Cancer Progression by MGAT1 shRNA Knockdown MGAT5 MGAT1 MGAT2 PMC6627996__F2 TLR2 signal pathway involved in oxidative stress TIRAP HEL-S-44 MYD88 PMC3185699__F1 Proposed signaling pathway to the actin cytoskeleton during HIV-1 entry in T lymphocytes ITK ARHA CXCR4 HDAC6 PMC6109047__F7 Pictorial Abstract SOX2 GSK3B MMP2 DVL2 MMP9 CCND1 CTNNB1 PMC5142237__F1 The canonical and noncanonical pathways by which the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is activated and elicits an inflammatory response NLRP3 TLR4 IL1B PMC5470118__F3 Canonical cannabinoid receptor (CBR)-mediated, G protein-dependent signaling pathways STAT3 MTOR SRC PMC5144105__F2 Signal transduction pathways in cranial development SMAD1 TCF12 DKFZp781O1323 WNT3A LRP5 SMAD4 LRP6 FGF5C RUNX2 CTNNB1 FGFR2 FRAT1 FGF7A ERF FGFR1 FGFR3 WNT3 TWIST1 MSX2 PMC9293517__F10 Explore the Therapeutic Composition and Mechanism of Schisandra chinensis-Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on Chemical Profile, Network Pharmacology, and UPLC-QTOF/MS-Based Metabolomics Analysis LOX PC TNF PMC3004331__F3 Differential host transcriptional responses within the acute-phase response pathway in r1918-infected WT, TNFRKO, and IL1RKO mice at 1, 3, and 5 dpi ECSIT TF VWF STAT3 TRADD HEL-S-62p SERPINA3 SERPINA1 HRG HAMP MTOR HEL-S-78p TRAF6 MYD88 AHSG C2 APOH F2 FGA HP LBP CP PMC3541025__F1 Autoinflammatory Disease Reloaded: A Clinical Perspective IL1R1 NLRP3 PSTPIP1 RAC1 PMC10540234__F8 Sulforaphane and bladder cancer: a potential novel antitumor compound CD40 LTBR RELB PMC6059697__F11 p53 signaling pathway obtained from the DAVID Database RFWD2 BAX TSC2 ATR FAS SIAH1 GDNF PERP ATM PTEN MDM2 MYC PMC3293632__F1 Control of the EGFR pathway and cell cycle entry by miRNAs RB1 STAT3 STAT1 EGFR PMC9372658__F1 TAK-242 ameliorates epileptic symptoms in mice by inhibiting the TLR4/NFKB signaling pathway TLR4 WAS PMC8231946__F2A Proliferation, dissemination and proteasome inhibitor resistance AREG CXCR4 PMC7697684__F3 New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance HEL107 PGAM1 PAICS CAD HK2 NADK UMPS HEL-S-70p PFAS DHODH ADSL PMC4974115__F1 Complement in disease: a defence system turning offensive PTX3 CD81 CD59 FH C5AR1 HEL-S-62p C1S CR2 VTN CD46 CD19 CD55 CR1 BCR CLU C4B_2 CP PMC7697684__F5 Major steps of glycolysis and direct and indirect regulation of glycolytic enzymes (in light blue) via Akt HEL107 PGAM1 HEL-S-133P HEL-S-68p PGM2 HK2 NADK HEL-S-162eP PFKFB2 ENO1 PMC4057522__F8 Possible mechanism implicated in tamoxifen resistance in the TAMR cell line model SOX13 SOX9 SOX3 CCND1 SOX4 PMC9461661__F4 Targeting Ferroptosis by Ubiquitin System Enzymes: A Potential Therapeutic Strategy in Cancer USP25 TF KEAP1 GPX4 LPCAT3 BAP1 USP11 FACL4 UCHL5 SLC7A11 USP35 USP14 RBX1 USP15 PMC9495541__F6 Cynanoside F Controls Skin Inflammation by Suppressing Mitogen-Activated Protein Kinase Activation LORICRIN TSLP IL1B PMC8634166__F8 Uncovering Bupi Yishen Formula Pharmacological Mechanisms Against Chronic Kidney Disease by Network Pharmacology and Experimental Validation IL16 TLR4 HK2 MYD88 PMC9461661__F3 Targeting Ferroptosis by Ubiquitin System Enzymes: A Potential Therapeutic Strategy in Cancer TF VDAC3 IBRDC1 ACSL3 KEAP1 GPX4 LPCAT3 FACL4 KLHDC3 SKP2 TRIM21 HERC2 RBX1 TRIM46 NEDD4 MIB2 HEL110 MDM2 RNF139 PMC4383535__F3 Genome Sequencing of the Perciform Fish Larimichthys crocea Provides Insights into Molecular and Genetic Mechanisms of Stress Adaptation TRH ADM HEL-S-87p HEL-S-30 PMC3077649__F7 Model of Egr-1/GGPPS/Erk1/2 pathway regulating insulin resistance in hyperinsulinism EGR1 SOS1 GRB2 SHE PMC8209548__F8 Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix Compaction CDC42 PAK1 FLNA RAC1 PMC4197584__F7 Pathway interactions regulating midgut patterning SOX17 FOXH1 NODAL PMC3476735__F5 Metformin, an anti-diabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway RHEB TSC2 TSC1 IGF1 AKT3 CCND1 IRS1 PMC8034938__F7 Celecoxib attenuated ZD-promoted tumorigenesis through suppressing inflammations IL16 PI3 CXCL5 CXCL2 CTNNB1 PMC7906116__F8 Interplay and roles of oxidative stress, toll-like receptor 4 and Nrf2 in trichloroethene-mediated autoimmunity TLR4 SFN MYD88 PMC6306737__F1 Metabolic pathway of lipid metabolism in muscle ACAD9 C2 CHAD CPT2 PMC3945337__F1 Quantifying the Sources of the Essential Sugar Mannose♦ PMC3871247__F6 TTC7A mutations disrupt intestinal epithelial apicobasal polarity TTC7A PTEN ARHA RHO PMC8965480__F9 Disease-associated microglial activation prevents photoreceptor degeneration by suppressing the accumulation of cell debris and neutrophils in degenerating rat retinas TREM2 AXL CD68 CSF1R PMC4214092__F1 Senescent cells in ageing PDP2 ATR CDK6 CDK2 ATM CDK4 PMC5103168__F6 Pre‐ and Post‐Natal Stress Programming: Developmental Exposure to Glucocorticoids Causes Long‐Term Brain‐Region Specific Changes to Transcriptome in the Precocial Japanese Quail TIMP3 STAB2 PSG5 MT1B TACR1 CACNA2D3 NPRC PMC7242738__F3 KEGG pathway for TNFA (bta04668) with the annotated DEGs in our results between Besnoitia besnoiti-infected BAEC cells at 32 hpi vs JUN MLKL EDN1 CS TNF TRAF2 FOS FADD PMC7697684__F8 New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance ACLY USP14 ATR RAD51 BRCA1 KDM5A UBE2S ATM PARP2 PARP1 PMC7697684__F7 Fatty acid synthesis and Akt-mediated regulation of lipid metabolism via phosphorylation of its targets and SREBP-dependent expression of various proteins (in light blue) ACLY FAS LDLR PMC7472444__F6 Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase NR1C1 OMP PPARGC1A PMC7472444__F5 Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase ASS1 HEL-S-53e HEL-S-133P CTH PCK1 ARG2 ASPA PMC7472444__F4 Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase ENO2 HEL-S-133P PFKP HK2 LDHB PCK1 PMC7377904__F2 Activation of the Wnt canonical pathway induces Beta-catenin-regulated gene expression APC GSK3B PMC7372973__F3 JAK-STAT signaling pathway IFNG STAT3 STAT1 IL13 JAK3 IL2 STAT4 IL6 JAK1 TYK2 PMC2707271__F5 Proposed mechanism for MAP4K3 cell death signaling BAX EIF4B BAD MAP4K3 PMC7377904__F3 Vitamin D interferes with Beta-catenin induced gene expression via different pathways in different cell types NR1i1 LRP5 CTNNB1 PMC5070418__F1 Signaling pathway involving mTORC1 RHEB TSC2 TSC1 NF1 ULK1 RYK PTEN KRAS EIF4E PMC8790935__F2 NLRP3 Inflammasome in Myocardial Ischemia-Reperfusion Injury and Ventricular Remodeling NLRP3 TXNIP MCU PMC3823708__F9 NFKB-Induced IL-6 Ensures STAT3 Activation and Tumor Aggressiveness in Glioblastoma STAT3 LIF SOCS3 JAK1 PMC7676916__F10 MiR-204-mediated regulatory mechanism in chicken granulosa cell (GC) proliferation, apoptosis, and autophagy ULK1 FOXK2 MTOR MLSN2 PMC10748092__F2 Colorectal Cancer Stem Cells and Targeted Agents CD44 EPCAM STAT3 CD24 SOX2 SMO MTOR GPR49 CTNNB1 PMC6890721__F4 Caffeine, theanine and catechin biosynthetic pathways in plants, and expression patterns of genes related to quality metabolites in ‘Xiaoxueya’ leaves F2 GC GAD2 AIDA XDH CS PMC9284495__F7 Bone marrow mesenchymal stem cells facilitate diabetic wound healing through the restoration of epidermal cell autophagy via the HIF-1A/TGFB1/SMAD pathway SMAD2 SMAD4 PMC7368941__F6 Function of podocyte injury is closely related to morphological changes ULK1 MTOR ULK2 SIRT1 PMC3652647__F7 Schematic model of probable pathway of refractoriness of interferonB signal TBK1 IRF3 NOD1 PMC3580164__F3 Transcriptional integration of mitochondrial biogenesis SIRT3 NR1C1 ULK1 YY1 SIRT1 PMC9036358__F1 Cyclic GMP and PKG Signaling in Heart Failure RYR2 RGS2 PGC NPS RGS4 TRPC6 PMC11853349__F7 Protective mechanism of dapagliflozin in sepsis-induced cardiomyopathy: The SIC model was established by animal experiments STAT3 PRDM10 PMC6985539__F1 Targeting molecules common to pathways promoting angiogenesis and neuroendocrine phenotype in prostate cancer RB1 AURKA ENO2 FOXA2 HDAC2 CREB1 ONECUT2 RET PMC5606335__F6 Oxygen-dependent regulation of antioxidant production by HIF1 MTHFD2 MTHFD1 PHGDH MTHFD1L SHMT1 PSAT1 HEL-S-51e PSPH PMC10815547__F8 Scheme of the ginsenoside biosynthetic pathway in ginseng according to Li et al MVP F11 GRB2 MVK SST NOTO PMC6710771__F1 Ang/Tie2 signalling in the diabetic eye, including crosstalk with the VEGF pathway RPE BAX GSK3B BCL2 SRC CTNNB1 PMC7072244__F2 ALK-EGFR-AKT pathway promote STING-dependent innate immune response in macrophage during bacterial sepsis TBK1 CGAS EGFR IRF3 PMC2690586__F1 Maintenance of the G1/S DNA damage checkpoint in the presence and absence of Cdk2 CDC2 ATR CDK2 ATM PMC8703190__F1 Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain SAG SHH SMO PMC6757314__F3 KEGG pathway analysis of the differentially expressed genes in head and neck squamous cell carcinoma PPARG LAMA1 CYP2E1 XPNPEP2 MGST1 IBSP COL10A1 HEL-S-4 CHAD PCK1 COL3A1 PLIN4 COL1A1 COL22A1 ALDH3A1 ATP1B4 COL4A2 COL4A1 COL4A5 SLC1A1 ADH1C AOX1 COL1A2 LAMC2 PLIN5 UGT1A10 LAMB4 UGT1A8 COL13A1 SPP1 COL2A1 COL6A1 XB AQP7 COL4A6 COL27A1 COL12A1 CYP3A4 COL5A2 LAMA3 PMC5900771__F1 Methylation and glycerolipid metabolism in yeast TG FAS PC PMC8703190__F2 Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain SAG SMO BDNF PMC6566801__F2 Possible mechanisms releasing mitochondrial components into the circulation TBK1 CGAS PINK1 NLRP3 OPA1 IL18 TLR9 IL6 IFNA1 PMC5388800__F1 Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging IFNG FAS TNLG8A BMF CD34 PMC7778590__F5 Targeting YAP for PDAC therapy LATS1 LATS2 RHO PMC11674716__F7 KEGG network diagram of the adipocytokine signaling pathway STAT3 LEP TRADD LEPR POMC NPY SOCS3 AgRP MTOR TRAF2 PMC7778590__F1 Core components of the Hippo pathway in mammalian cells LATS1 LATS2 NF2 VGLL4 PMC8144525__F8 Tibetan Medicine Duoxuekang Capsule Ameliorates High-Altitude Polycythemia Accompanied by Brain Injury RAF1 EPO GRB2 PMC9419985__F3 Hematopoietic Stem Cells in Wound Healing Response TF TLR4 GFI1 MYD88 PMC9419985__F2 Hematopoietic Stem Cells in Wound Healing Response TF TLR4 GRB2 SRC MYD88 PMC4909440__F1 Mechanistic consequences of PREX2 truncating mutations CDKN1C PTEN PREX2 IGF2 RAC1 PMC9395635__F1 Road testing new CAR design strategies in multiple myeloma IL2RB CD34 PMC7241259__F2 Wnt pathways ROR2 GSK3B LRP5 LRP6 ATF2 ARHA CTNNB1 PMC8550922__AF1 Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling Pathway CDC42 AGO2 CYP2E1 KIN PMC7037240__F1 GM-CSF–IRF4–CCL17 pathway in inflammation and pain IRF4 TNF CCL17 PMC7709111__F5 Three top-scoring interaction networks of highly abundant aqueous humor proteins KRT1 C6 SERPIND1 KRT10 SERPINF2 TGFBI SPARC CD22 PCOLCE NEGR1 GPX3 SCG3 AHSG CFI RBP3 VGF GC C9 MMP2 A2M PRELP HEL-S-2 C7 APOD SERPING1 APC ORM1 SERPINA1 PLG HRG B2M FCGBP RELN NPC2 SCG2 CHGB PON1 KRT9 FGA IGFBP7 LCN2 PSAP SPON1 HEL-S-22 OPTC TIMP1 HSPG2 BTD SPARCL1 F5 HEL-S-62p VTN LYZ IGFBP2 AFM C4A IGFBP6 ORM2 APOA4 AGRN APOH F2 ALDH3A1 HABP2 APP C4B_2 HBB KNG1 ITIH4 ITIH2 SERPINC1 HMFT1766 A1BG C8G DAG1 UBC KRT2 CFD CUTA AMBP CFH RBP4 PRNP NTM CLEC3B HBA2 SPP1 MYOC APOA2 HEL-S-130P IGFBP5 C2 GUGU C8A HP PS1TP5BP1 PMC5549331__F1 Molecular pathways of macrophage polarization STAT3 STAT1 MRC1 TLR4 IRF3 IRF4 CXCL10 MYD88 PMC6070815__F5 Pathways of the annotated DE genes and lincRNAs in the adipose tissues of high- and low-FE pigs GNAS ATP2B2 ABCD2 PDE1A ABCB4 NR4A3 LIPE VIPR2 PMC11906677__F7 Mechanism of PP suppressing NLRP3 inflammasome by targeting CK1A–Beta-catenin–NFKB–NRF2–mitochondrial OXPHOS pathways during bacterial infection GSDMD NLRP3 CTNNB1 PMC4178922__F2 Fgf7 and Fgf10 signaling via Fgfr2b controls proliferation versus chemotaxis, respectively FGF7 SH3BP4 FGF10 PMC4017039__F1 Intracellular signal propagation of human toll-like receptors and corresponding ligands in innate immunity TLR1 TLR3 TIRAP TLR4 TLR9 CD14 IRAK1 TLR5 TLR7 TRAF6 IRAK4 MYD88 PMC5949531__F2 Nerve growth factor (NGF) signaling cascade CRK NGF ARHA SHE TRAF6 PMC2638772__F9 Model whereby increased Fgfr3 signaling in chondrocytes causes premature synchondrosis closure and unification of ossification centers MAPK1 BMP2 BMP7 PMC2869094__F1 Epigenetic regulation of WNT signaling in chronic lymphocytic leukemia CCND3 DVL1 JUN ITCH APC GSK3B LRP5 LRP6 PPP2CA DVL2 MYC CTNNB1 TLE2 BCL9 CCND2 FOSL1 LEF1 CCND1 WIF1 PMC3788328__F1 Calcium and calcium-permeable channels in the control of autophagy TRPV5 TRPM2 TRPV2 TRPV1 MCU MTOR TRPV6 TRPM8 PMC4496399__F6 NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib CD44 NGF ARHA PMC5841365__F2 Macroautophagy: an overview of the molecular pathway and mutations associated with congenital disorders of autophagy ATG10 WDR45 ATG3 NPC1 ATG12 ULK1 SPG11 SNX14 ATG14 KIAA1632 ATG5 PMC7904579__F7 Applying Genome-wide CRISPR to Identify Known and Novel Genes and Pathways that Modulate Formaldehyde Toxicity SLC3A2 EIF4B LAMTOR3 GSK3B LRP5 TTI1 FLCN MTOR LAMTOR2 SKP2 DEPTOR EIF4E RHEB TSC2 TSC1 LAMTOR1 SESN2 RNF152 RRAGA PMC3940969__F1 Cytokine signaling pathways in brain preconditioning TRADD CCR2 TRAF6 CCL2 TRAF2 MYD88 PMC7206068__F5 TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses TRIM14 TBK1 TRIM38 CGAS TRIM32 TIRAP IRF3 TRIM21 MYD88 USP14 IFNG TLR3 TLR4 TRIM23 PMC7206068__F3 TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses TRIM16 TRIM49 TRIM32 ULK1 TRIM17 TRIM59 TRAF6 TRIM21 ATG101 IFNG TRIM28 TRIM37 TFEB AMBRA1 TRIM6 TRIM65 PMC9710844__F7 Graphical abstract of DDOST-regulated MITA-mediated signaling pathway TBK1 CGAS IRF3 PMC5556685__F2 Working model illustrating the potential impact of milk exosome-derived miRNAs on the expression of p53 BAX TSC2 IGF1 FOXO1 PTEN IGF1R PMC8005985__F5 Regulatory function of main lncRNAs related to cardiomyocyte maturation PHB2 FIS1 MCM3 DACH1 CRIP2 YAP1 PMC8005985__F4 Regulatory effect of H19-LncRNA in cardiomyocyte maturation TESC SOX6 GSK3B PMC316782__F1 Genetic pathways of sex determination in D PMC2664743__F4 Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity BDNF PMC8294626__F8 H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease EN2 LRP5 LRP6 AXIN2 ATP6AP2 CTNNB1 PMC7399735__F6 Gene-to-gene network of Col-0 vs DCD AGO1 AGO2 ARF3 NPRC HEL-S-44 PMC6701373__F2 Transforming growth factor-Beta- (TGF-Beta-) induced EndoMT SMAD2 SMAD4 MTOR CDK4 PMC4033420__F1 Colorectal cancer MSI and CIN signaling pathways modified from KEGG database BAX CASP9 DCC SMAD2 APC CASP3 SMAD4 BCL2 KRAS CTNNB1 TGFBR1 PMC3571329__F7 Proposed metabolic model for syntrophic growth of D POR HEL-S-133P PMC7151181__F3 Signal transduction pathways activated by GlcNAc TEC TPK1 PMC12196518__F1 Mechanisms of LSEC defenestration and the role of defenestrated LSEC in liver fibrosis LPA STAT3 KLF2 VCAM1 POFUT1 RHO TNF PMC4324503__F5 Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation TLR4 CFTR PMC11312279__F9 Ceramide Ehux-C22 Targets the miR-199a-3p/mTOR Signaling Pathway to Regulate Melanosomal Autophagy in Mouse B16 Cells MC1R ULK1 MTOR ATG5 PMC8276988__F2 Immunogenic Cell Death: A Step Ahead of Autophagy in Cancer Therapy BAX PANX1 ATG16L1 ATG12 ATG5 VAMP7 PMC5131917__F8 PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress RAD18 SDE2 PCNA PMC12209307__F9 Diagram of the mechanisms by which tricin fighting against KRAS-mutant NSCLC IFNG FOSB JUNB SRC PMC9588367__F8 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis AURKA SYK PIK3CA EGFR PIK3C2A EPO MTOR CCL2 ALB PLAT NAAA ALOX5 PPBP COX2 ND6 CNR2 POLG F10 COX3 KDR TYMP CDC2 P2RX7 ACHE IL10 MPV17 SELE KIT IL6 C10orf2 CYB IDO1 ERBB2 CDK2 CYP3A4 PMC9288447__F1 Restored oligodendrogenesis by fibroblast growth factor 17: molecular mechanism for rejuvenating ageing-related memory deficit FGF6B FGFR3 PMC9588367__F5 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis FLT3 ZAP70 AURKA STAT3 SYK PIK3CA PIK3CD PIK3C2A EPO CCL2 MAPK14 ALB IFNG NLRP3 COX2 ND6 F10 COX3 FLT1 RRM2B KDR P2RX7 RAD51 CYP2C9 CDK2 DGUOK F5 EGFR MTOR PLAT NAAA PPBP CYP2C19 POLG CNR2 ELANE TYMP CDK4 ACHE IL10 LRRK2 SELE KIT IL6 C10orf2 RORC CYB IDO1 ERBB2 CYP3A4 PMC5413598__F1 Hippo signaling pathway LATS1 LATS2 HEL70 NF2 VGLL4 PMC4092141__F1 cGMP and NHR Signaling Co-regulate Expression of Insulin-Like Peptides and Developmental Activation of Infective Larvae in Strongyloides stercoralis PI3 SKI PMC7686857__F1 Mitochondrial iron co-factor biosynthetic pathways are reliant on FXN iron chaperone function ISCU FECH PMC4705527__F5 Deciphering the streamlined genome of Streptomyces xiamenensis 318 as the producer of the anti-fibrotic drug candidate xiamenmycin IPP MAL CIT PMC5964135__F2 Proposed signaling cascades recruited in the setting of remote ischemic conditioning based on available data BAX BAD PMC3039924__F1 Insulin-like growth factor receptor 1 (IGF1R) signaling pathway and potential mechanisms of resistance to IGF1R blockade (red asterisks) RHEB IGF2R BAD RICTOR TSC1 INSR EGFR PTEN MTOR IRS1 EIF4E PMC9616789__F10A Spatial Analysis of Neural Cell Proteomic Profiles Following Ischemic Stroke in Mice Using High-Plex Digital Spatial Profiling LPL ACHE IDE ATR BAD COMP CAD BPI CASP12 APC ATG14 TNF POR ALK CASP3 SI MCU APP FADD PMC5868625__F6 Summary of the inhibitory effect of ILQ on PI3K/Akt/mTOR pathway members.Abbreviation: ILQ, isoliquiritigenin GSK3B MTOR CCND1 CTNNB1 PMC9433414__F3 Interaction between the circadian clock and mTOR-related signaling transduction pathways VIP SIK1 PER2 PER1 PTEN DEPTOR IRS1 EIF4E RHEB MLST8 TSC2 TSC1 TBC1D7 GRB2 PMC11913671__F2 Inflammatory pathways in glomerular disease STAT3 STAT1 NLRP3 PTPN11 STAT4 LAIR1 HDAC6 PMC5243181__F1 Differential gene expression in PPAR signaling pathway LPL UBC AQP7 UCP1 HEL-S-28 PLTP PMC8396474__F1 Redox Signaling and Sarcopenia: Searching for the Primary Suspect SIRT3 FOXO1 FOXO3A F3 MTOR SIRT1 PMC8615799__F9 Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma CDC42 CD44 HGF PC RHOV PMC3722447__F1 Defects within components of the ECM and the TGFB signaling pathway leading to various HCTD TF TGFBR2 SMAD2 SMAD4 TGFBR1 PMC4211700__F4 PKCD and θ Possibly Mediate FSH-Induced Mouse Oocyte Maturation via NOX-ROS-TACE Cascade Signaling Pathway EGFR AREG FSHR PMC2945562__F8 Summary of signaling pathways for cPLA2A activation and eicosanoid production stimulated by engagement of C SYK COX1 COX2 MYD88 PMC8616420__F3 Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer FAS CASP8 PLK3 CASP3 PTEN HIF1A MTOR FADD PMC8616420__F2 Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer RAD51 BRCA2 ATM CCND1 PMC2662697__F6 Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88 Dependent and Independent Signaling and is Reciprocally Modulated by LXR Activation CD36 TLR4 CD14 IRF3 ABCA1 MYD88 PMC5585386__F6 Schematic representation of a B LPA DGAT1 DGAT2 HEL-S-5 PC PMC6709694__F4 Integration of HTS and CTD informs disease-pathway connections TH MAK AMT TNF PMC8201405__F4 Herpes Simplex Virus 1 Infection of Neuronal and Non-Neuronal Cells Elicits Specific Innate Immune Responses and Immune Evasion Mechanisms TBK1 CGAS TRIM32 IRF3 PMC8201405__F3 Herpes Simplex Virus 1 Infection of Neuronal and Non-Neuronal Cells Elicits Specific Innate Immune Responses and Immune Evasion Mechanisms TLR3 TLR9 IRF3 IRF7 TRAF3 TRAF6 MYD88 PMC3382968__F1 The four principal manifestations of immunological autophagy NLRP3 AIM2 TRAF6 PMC3460045__F3 Pathological functions of LOX family oxidases during cancer progression and metastasis CRK LOX GSK3B HIF1A VEGFA PMC9011227__F1 Lipid rafts in persistent Helicobacter pylori infection: a narrative review CXCL9 STAT1 JAK1 PMC7802409__F3 Microglia damage to neurons after encephalitis leads to neurological complications in survivors IFNG IL16 P2RY13 PELI1 PMC12157993__F10 TV-EV-induced inflammatory cascade in host cells TRAF3IP2 NLRP3 TLR3 CXCL1 MICB PMC10915131__F6 Working model for the role of the mechanistic target of rapamycin complex 1 (mTORC1) and its regulated macroautophagy in the induction of cardiomyocyte necroptosis by large doses of isoproterenol (ISO) RIPK3 MLKL TFEB RIPK1 PMC4657734__F2 Smad complexes can cooperate with transcription pathways in the control of gene expression in epithelial-mesenchymal transition FOXA1 FOXC2 LAT SMAD2 GSK3B SMAD4 SHH SMO FOXA2 ZEB2 RBPJ CTNNB1 PMC4657734__F1 TGF-Beta-activated non-Smad pathways in epithelial-mesenchymal transition CDC42 TRAF4 SMURF1 SMAD2 SMAD4 ATF2 ARHA RAC1 PMC12090520__F9 Mechanism by which F1929-1458 activates anti-tumor immunity CD80 HMGB1 CGAS NFKB1 CCR7 PMC8633599__F2 Molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development GRPR ITCH NPPB PMC3685413__F2 SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia MSH4 SPOP CHD8 CD14 CREBBP RYK CPSF2 MYC FANCA IRAK4 CCNB3 CTNNB1 PMC6131564__F4 Sub-pathway of the HIF-1 signaling pathway identified on the basis of sub-pathway strategy MAPK1 VPS11 EIF4EBP1 EGFR EP300 HIF1A IGF1R MAP2K1 ZNF761 EGLN3 MAP3K14 PMC9449579__F3 Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy CYP24A1 SOAT2 SQLE GSK3B SOAT1 PTEN MDM2 MTOR CTNNB1 PMC6131564__F3 Sub-pathway of chemokine signaling pathway identified on the basis of sub-pathway strategy GNB2 GNB5 c-fgr MAL NRAS MAP2K1 SHC2 GRB2 PMC8997990__F6 FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells SFTPB FOXO1 SFTPC PMC6131564__F2 Sub-pathway of the MAPK signaling pathway identified on the basis of sub-pathway strategy MAPK4 MAP2K4 MAP3K1 MOS MAP2K1 MAP2K3 FOS PMC9449579__F1 Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy IPP HMGCR SQLE FDPS FDFT1 PMC8122029__F7 Transcriptome profiling of insulin sensitive tissues from GH deficient mice following GH treatment IRF9 CYC1 PMC9588367__F3 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis FLT3 AURKA STAT3 SYK PIK3CA RAF1 KLKB1 PIK3CD EPO MAPK8 CCL2 SLC25A4 MAPK14 ALB IFNG HSPD1 ALOX5 NLRP3 F10 FGFR1 PTGS1 FLT1 RRM2B KDR P2RX7 MPV17 RAD51 AURKB CYP2C9 CDK2 DGUOK TBK1 F5 EGFR MTOR PLAT PPBP CYP2C19 POLG CNR2 ELANE TYMP CDK4 CDC2 ACHE IL10 LRRK2 SELE KIT IL6 PABPC1 PARP1 RORC IDO1 PRKDC CHEK1 ERBB2 CYP3A4 PMC9588367__F2 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis ACHE ZAP70 AURKA RORC PLAT CYP2C19 CNR2 F10 POLG CYP2C9 TYMP PMC5846366__F2 Molecular targets of natural compounds in breast cancer pathway FAS COX1 COX2 FADD PMC11735026__SF4_3. GnRH signaling pathway: The KEGG graph shows the involvement of ADCY3 and MMP2 genes driving the GnRH signaling pathway CDC42 MMP14 CGA RAF1 LHB SOS1 EGFR MAPK8 MAPK14 GNAS CAMK2A MMP2 ATF4 SRC MAP2K3 JUN EGR1 PTK2B FSHB HRAS HBEGF GNRHR MAP3K1 ADCY3 MAPK7 GNA11 CALM1 PLCB2 GRB2 PMC3559784__F5 The Carcinogenic Liver Fluke, Clonorchis sinensis: New Assembly, Reannotation and Analysis of the Genome and Characterization of Tissue Transcriptomes CTSF RAN COMP PMC4898879__F7 Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light CORT OPN4 PMC7341904__F1 Upregulation of the MAPK pathway in tumor cells leads to proliferation and progression of thyroid cancer SSTR2 BRAF MTOR RET PMC8353273__F2 Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases TRIM14 TRIM38 CGAS TRIM32 TRIM56 ULK1 TRIM41 SENP7 ENPP1 RNF26 TTLL6 INSIG1 TTLL4 AMFR SENP2 USP21 ULK2 RNF185 RNF5 PQBP1 IFI16 SAR1A SEC24C NLRC3 DDX41 MUL1 TRIM29 ZCCHC3 PMC8766746__F5 Robo2 and Gen1 Coregulate Ureteric Budding by Activating the MAPK/ERK Signaling Pathway in Mice ROBO2 ETV5 SLIT2 GDNF GREM1 GEN1 RET PMC3806315__F4 Serine, glycine and the one-carbon cycle: cancer metabolism in full circle GLDC AMD1 HEL-S-182mP PHGDH PMC8353273__F1 Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases TBK1 CGAS IRF3 PMC8821531__F6 T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects ATM INS PMC6738402__F1 Role of Fyn in misfolded Alpha-synuclein (ASyn)-mediated NLRP3 inflammasome activation FYN NLRP3 CD36 PMC11942496__F3 Function of the MAPK Signaling Pathway in Cardiac Hypertrophy BMP7 MTOR MAP2K3 PMC3806315__F2 Serine, glycine and the one-carbon cycle: cancer metabolism in full circle GLDC DHFR HEL-S-61p PMC2778737__F4 Nephron development and cell lineages FOXD1 CITED1 TLE4 SIX2 WNT4 RET PMC9179380__F2 NOTCH1, GATA3, and c-MYC in T Cell Non-Hodgkin Lymphomas CD44 C6 FLT3 FAS HEL-S-62p C2 KIT RAG2 RAG1 FOXP3 PMC9179380__F1 NOTCH1, GATA3, and c-MYC in T Cell Non-Hodgkin Lymphomas CD40 TH ICOS FOXO1 SMAD2 IL21R AHR IRF4 FOXP3 BCL6 GATA3 PMC8122951__F2 Bone Marrow Niche in B-Cell Acute Lymphoblastic Leukemia: The Role of Microenvironment from Pre-Leukemia to Overt Leukemia PTX3 CXCL12 CCR2 CCL2 CX3CR1 CX3CL1 BMP4 MSC MVD VCAM1 NOTCH3 CD163 CXCR4 PMC3158866__F1 Toll-like receptor signaling pathway HMGB1 TIRAP TLR9 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 PMC5678904__F3 TGF‐B/SMAD/CTCF signaling pathway CTCF SMAD2 SMAD4 PMC2949647__F1 Structure and signaling machinery of the Met receptor CDC42 CRK GRB2 RAC1 PMC10912471__F2 Notch signaling pathway in tumor immune microenvironment PMC10912471__F1 Notch signaling pathway JAG2 FHL1 RBPJ PMC4824345__F7 The GacS/A-RsmA Signal Transduction Pathway Controls the Synthesis of Alkylresorcinol Lipids that Replace Membrane Phospholipids during Encystment of Azotobacter vinelandii SW136 PMC3785008__F1 Role of hypoxia and HIF2A in development of the sympathoadrenal cell lineage and chromaffin cell tumours with distinct catecholamine phenotypic features NGF HEY2 DLL4 MTOR VEGFA HES1 HEL-S-44 PMC8659360__F1 Selective Progesterone Receptor Modulators—Mechanisms and Therapeutic Utility EGF SMAD2 SMAD4 WNT1 PMC5435970__F7 Model depicting the mechanisms by which TIEG1 modulates canonical Wnt pathway activity in osteoblasts APC GSK3B LRP5 LRP6 LEF1 PMC9161817__F1 Autophagy and the Bone Marrow Microenvironment: A Review of Protective Factors in the Development and Maintenance of Multiple Myeloma ATF4 ATG5 PMC4346003__F5 Gene network, created using IPA® software, reflecting EGCG treatment.Notes: The overexpressed genes are labeled in red, while those downregulated are marked in green.Abbreviations: EGCG, epigallocatechin-3-gallate; IPA, Ingenuity®Pathway Analysis FAS AIP MYC PMC2939633__F1 Chk1 suppressed death pathways BAX ATR CDC45 ATM PMC8323007__F3 MicroRNA-490-3p and −490-5p in carcinogenesis: Separate or the same goal? STAT3 PIK3CA TNKS2 SP1 EGFR SMAD2 GSK3B LRP5 SMAD4 LRP6 TGIF2 MTOR VEGFA ARHA TGFBR1 CTNNB1 TSC2 FRAT1 TSC1 CCND1 PMC3614012__F2 IGF-1R and EGFR/HER2crosstalk occurs by two main mechanisms IGF1 EGFR IGF1R IGF2 PMC7792208__F1 Multistep model of the evolution of classic ILC and its morphological variants ERBB3 ARID1A PIK3CA ERBB2 PTEN PMC5751361__F12 TGFB signaling pathway SMAD2 SMAD4 GRB2 PMC4946436__F8 Interplay between ErbB3 and CXCR4 for the activation of Rac1 and breast cancer cell motility ERBB3 HRG ERBB2 CXCR4 RAC1 PMC4134798__F1 Mechanism of bone resorption in bone marrow metastasis LPA CXCL12 IGF1 VCAM1 CXCR4 PMC4669118__F9 Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway CDC42 ARHGEF9 IQGAP1 PMC4880855__F1 The (simplified) gene regulatory network controlling primary sex determination in placental mammals (see Additional file : Figure S1 for the more complete network) DMRT1 SOX9 SRY FGF9 WNT4 GATA4 PMC9613846__F3 Transcriptome and Metabolome Analyses Reveals the Pathway and Metabolites of Grain Quality Under Phytochrome B in Rice (Oryza sativa L.) MAX BIN2 EBF2 MPG ACSF3 CYCS ELF2 SDHA ELF4 LOX ELF1 HEL-S-162eP SUI1 DLD HEL-S-32 BAK1 PMC8503804__F2 Circular RNA regulates the onset and progression of cancer through the mitogen-activated protein kinase signaling pathway FAM83A RAF1 EGFR FGFR1 TCF2 VEGFA HMGB3 MYD88 PMC3322137__F3 Pathway-Based Evaluation in Early Onset Colorectal Cancer Suggests Focal Adhesion and Immunosuppression along with Epithelial-Mesenchymal Transition CRK BAD VASP PTEN ARHA PMC1464269__F1 Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies TG MAL CIT PMC3113646__F6 TGFBeta-and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR) TIMP3 PI3 MTOR EIF4E PMC2944409__F7 Gene interaction sub-network of shortest connections to common targets for the 36 candidate regulatory genes obtained by global literature analysis (Pathway Studio 7.0, Ariadne Genomics Inc., Rockville MD) PRLR THOC2 MMP14 PRMT2 TIMP1 THY1 EGFR PTGS2 MMP9 VEGFA CCL5 TNF NEDD4 PRP4K MMP2 BCL2 VCAM1 CXCR4 ACTG2 GJA1 CCND1 TIA1 PMC2944409__F6 Calcium Signaling Pathway (KEGG, Kanehisa Laboratory in Kyoto University, Japan) with vinclozolin altered genes indicated PLN BCR MCU PMC3712669__F1 The estrogen metabolic pathway is depicted DIO1 CYP3A4 PMC3708595__F4 Mutational Landscape of Adenoid Cystic Carcinoma MAX ARID1A MYB KANSL1 BCOR DTX4 PTEN MORF4L1 SETD2 MYC MGA SRCAP KDM6B SMARCE1 FBXW7 TLK1 MAML3 INSRR FGFR4 FOXP2 ATM MYCBP MYBL1 BCORL1 KAT6A SMC1A HRAS JMJD1C BRCA1 MAGI1 PRKDC NFIB CREBBP EP300 MAP2K2 UHRF1 ARID4B PMC5667900__F4 Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway SLC3A2 GPX4 LPCAT3 FACL4 HFE SLC7A11 PMC4642978__F2 Differential Gene Expression Profiles and Selected Cytokine Protein Analysis of Mediastinal Lymph Nodes of Horses with Chronic Recurrent Airway Obstruction (RAO) Support an Interleukin-17 Immune Response PTX3 SMAD9 LOX SAA2 RBP4 FGA AQP5 CP PMC7685705__F9 The role of TRAF3 in density-dependent proliferation RELB TRAF3 TRAF2 PMC11650353__F7 Proposed model of curcumin inhibiting PCa progression via regulation of m6A-modified circ0030568-FMR1 pathway YTHDF2 METTL3 FMR1 PMC7411855__F3 MAPK and NFKB signaling pathway of ginkgolides in the regulation of IIR TBK1 TLR1 TLR4 IRAK1 IRF7 IRAK4 MYD88 PMC3334999__F5 Unique Combination of Male Germ Cell miRNAs Coordinates Gonocyte Differentiation JUN SOX11 SOX12 APC GSK3B SOX2 TCF4 APPL2 TGFBR1 CTNNB1 TGFBR2 CD44 FZD1 NLK DKK2 PMC9448717__F1 Anti-factor H antibody and its role in atypical hemolytic uremic syndrome C6 FH C7 HEL-S-62p C9 PMC3334999__F6 Unique Combination of Male Germ Cell miRNAs Coordinates Gonocyte Differentiation TGFBR2 BAD CBL AFP BMPR1A EGFR PTEN KRAS GHR PMC9577795__F4 Identification of key genes and pathway related to chemoresistance of small cell lung cancer through an integrative bioinformatics analysis EDN2 FOXA3 KRT19 TM4SF13 NPTX1 EVC SCG5 CXNO MAP6 NPY TMEM119 AHNAK AQP5 APOC2 UGT1A3 SGTB TOM1L2 NTRK2 FOXF2 MASP1 GFAP DYNLT3 SCG2 AATK RNF113A CYP7B1 AQP1 LPGAT1 FAM89A KRTCAP3 FUT4 MAPK13 MS4A12 HMSD ZNF831 FAM83E STK38L PRELID2 LRTM2 TGDS TMEM187 EFHD1 WDR5 SLC13A2 DDX51 RAB40A CHRNA3 RPRML UBTF CCND2 GALR2 CXADR VWF RRAGD STK17A GLIPR1 TEX19 ASGR1 ZIC3 GPS1 ADA MMS19 CDH19 PEX10 KCNN1 SHROOM2 CD74 LNPEP ZNF655 PRSS2 DOK3 TRIB3 TSPAN15 CPEB3 KCTD17 PENK INPP5D COL23A1 FOS PCK2 GPR143 S100A16 SLN ACLY FERMT3 SLC29A4 SFN INS NPTX2 OLFM1 RUSC2 AMH DGKZ PPP2R5D TRAPPC6B ZNF701 NEUROG2 AQP3 RAB33A KCNMB4 NGFR TFG BMP7 NLRP2 NEUROD2 SSTR3 MED22 HOXB7 PODN ZNF264 RAB32 GHITM PMC11042021__F8 KEGG pathway diagram for antigen processing and presentation illustrating the central processes involved in antigen processing and presentation, which are essential for immune system function IFNG HEL-S-99n TAPBP CANX TAP1 B2M TAP2 PMC9577795__F3 Identification of key genes and pathway related to chemoresistance of small cell lung cancer through an integrative bioinformatics analysis ACLY CHST14 VWF JUN PTN COL1A2 OSM MAPK13 CHRM1 PMP22 SPARC ADAMTS3 INS RHOU STAT1 IGF1 MED22 SSTR2 LAMB3 BMP2 WNT1 MAP2K3 PMC11042021__F7 KEGG pathway diagram for graft-vs.-host disease depicting the complex interplay of cellular and molecular interactions involved in the pathogenesis of graft-vs.-host disease (GVHD) APC TNF PMC9600014__F1 Amyloidogenesis and Neurotrophic Dysfunction in Alzheimer’s Disease: Do They have a Common Regulating Pathway? BACE1 APP PMC7601265__F7 Illustration of hypothetical antioxidant mechanism for peptide MS15 against oxidative stress KEAP1 MAF GPX1 HEL-S-44 PMC6195737__F2 IGF signaling in the placenta IGF1 BCL2 IGF2 PMC1782796__F7 Affinity maturation, a turning point between life and death for germinal centre (GC) B cells: a working hypothesis CD40 BIN2 AKNA PMC4268052__F6 Holoprosencephaly: signalling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans SMAD1 DKFZp781O1323 BOC GAS SMAD2 SHH SMO NODAL PMC4633891__F10 MiR-148a promotes starvation-induced autophagic activity in HSCs, at least in part, through suppressing the Hedgehog signaling pathway SMO GAS1 PMC1955177__F3 Cell death in the cardiovascular system IGF1 BNIP3 IGF1R MTOR UNK PMC5895746__F2 Schematic representation summarizing the functional effects of the three regulatory pathways controlled by IL-1B MIA REST IL1RAPL1 MTOR IL1B PMC4642978__F1 Differential Gene Expression Profiles and Selected Cytokine Protein Analysis of Mediastinal Lymph Nodes of Horses with Chronic Recurrent Airway Obstruction (RAO) Support an Interleukin-17 Immune Response LOX DEFB4B VPREB1 SAA2 RBP4 FGA AQP5 PMC11574184__F6 KEGG pathway analysis TRADD SELE INA NOD2 TNF CYLD PMC9206341__F8 Near-infrared light reduces Beta-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease TLR4 IL18 SRC PMC1143566__F4 Schematic diagram for the Wnt signaling pathway CDC42 APC RHO DAAM1 CTNNB1 PMC4271245__F7 Proposed model linking TBX2 and TBX3 to the TGFB1 signaling pathway TBX2 SMAD2 SMAD4 TBX3 PMC1143566__F2 A schematic diagram for the hedgehog (HH) signaling pathway SUFU DHH SHH IHH SMO PMC6281419__F1 PHIPing along: Evolution of PHIP as a cancer biomarker and a target for therapy IGF1 TLN1 IGF1R PHIP CCND1 IGF2 IRS1 PMC9083544__F1 Engineering Yarrowia lipolytica to Produce Itaconic Acid From Waste Cooking Oil CAD PEX10 CIT PMC10286596__F2 Resveratrol-modulated mitochondrial biogenesis in neurodegenerative diseases TFAM FOXO1 FOXO3A SIRT4 NAMPT TERT SIRT1 PMC10286596__F1 Mitochondrial biogenesis in neurons TFAM TFB2M TFB1M POLG MTIF2 NRF1 MTIF3 SIRT1 POLRMT PMC9563396__F5 Molecular Mechanism of Ferroptosis in Orthopedic Diseases STAT3 GPX4 SLC7A11 PMC11827847__F10 Hypothesized mechanism by which NRP1 mediates NGF/TrkA pain signaling NGF NRP1 PMC9604036__F2 Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases IFNG AHR IL1B PMC7959192__F9 Simplified pathway for NAD metabolism NAPRT SARM1 NAMPT PMC2700095__F10 Alternative kinetic model incorporating unknown transcription factor (TFx) activation by Eda/Edar signaling EGF TGFA EGFR RELA SHH EDARADD TRAF6 EDAR TRAF2 FGF8 TNLG7C PMC8201398__F2 Bacteriostatic Potential of Melatonin: Therapeutic Standing and Mechanistic Insights STAT1 NLRP3 TLR4 MUC2 FOXP3 PMC6826302__F2 Mechanisms mediated through IGF-1/IGF-1R IGF1 IGF1R IRS1 PMC6826302__F3 Mechanisms mediated through vitamin D NR1i1 EGF IGFBP5 SPARC CTNNB1 PMC8381213__F1 Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense STAT2 IRF9 IRF3 ISG15 TYK2 PMC8539140__F3 LncRNAs in the Regulation of Genes and Signaling Pathways through miRNA-Mediated and Other Mechanisms in Clear Cell Renal Cell Carcinoma LATS1 BIRC5 EZH2 TUG1 CCND1 PMC8281578__F1 Neutrophil extracellular traps in cancer: not only catching microbes TLR4 MPO PMC8381213__F2 Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense MAVS STAT2 IRF9 IRF3 FADD NUP98 PMC6859340__F7 Mechanism of Cdc42/Wnt/Beta-catenin signaling pathway in ADSC-derived IPCs CDC42 TCF7L2 PDX1 NEUROD1 WNT3A APC CTNNB1 PMC11688120__F3 Key signaling pathways in the pathogenesis of CCM HEG1 KLF4 PIK3CA KLF2 SMURF1 TLR4 CD14 ARHA MTOR PMC9009237__F5 “Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications GAA KEAP1 PMC239898__F6 Activation of the MAPK signaling pathway by FSH, ATP and GnRH in ovarian cancer GNRHR FSHR PMC6079386__F14 Gga-miR-302b-5p and gga-miR-302-3p miRNAs TRPS1 LATS2 F2 E2F7 NLK PMC8656040__F1 Ketone bodies: from enemy to friend and guardian angel HMGCL BDH1 PMC9009237__F4 “Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications NLRP3 TNF IL1B PMC6954292__F1 Androgen metabolism in human prostate HSD17B6 CYP17A1 HSD3B1 HSD17B2 AKR1C2 PMC11034170__F3 Updated mechanisms of MASLD pathogenesis SLC3A2 STEAP3 GPX4 AMT PMC8761570__F2 Poly (I:C) induces an immune response by macrophages LIPA NOS2 OLR1 GLG1 HEL-S-30 PMC1899986__F8 A model for cyclin E degradation regulated by two E3 ligases RBX1 CDK2 SKP1 CDC34 PMC139433__F2 Cell cycle arrest by transforming growth factor (TGF)B and their deregulation in cancer SMAD2 SMAD4 CDK2 CCND1 CDK4 PMC4606200__F1 Programmed death-1 causes T cell exhaustion ZAP70 STAT1 STAT2 IRF9 JAK1 TYK2 PMC5928215__F1 Protein and cell turnover of the skeletal muscle STAT3 SMAD2 TNF IL6R IRS1 PMC9541052__F1 Severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians TF VWF PLG F11 CD40LG PF4 PMC3409633__F1 TLR signaling controls transcription and mRNA half-life TLR4 IRAK1 IRAK4 PMC2725945__F1 Stabilization, degradation, and activation of the Ci/Gli proteins by the Hh signaling pathway SPOP SUFU SMO PMC2666548__F1 Reactions and proteins of the mitochondrial FAS pathway MCAT MECR AASDHPPT OXSM RPP14 HTD2 HEL-S-5 PMC9009237__F6 “Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications DRD2 APC GSK3B LRP5 LRP6 CTNNB1 PMC4768070__F2 BST‐2 in viral infection: BST‐2 tethers viruses to the cell membrane and to each other (1) and (2) MAP3K7IP1 PDC PMC8269449__F1 Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs LTA COX1 APC PMC6447179__F7 Traumatic brain injury induces long-lasting changes in immune and regenerative signaling C6 C8G CR1L C5AR1 SERPING1 HEL-S-62p C3AR1 CFD C1S C1R C4BPB C1QB C1QA C2 C4BPA C1QC PMC6447179__F9 Traumatic brain injury induces long-lasting changes in immune and regenerative signaling HMOX1 ATF3 CXCL12 EGR1 FABP5 CCL3 MGP JUNB SIGIRR CXCL2 ANGPT2 FOS PMC7042402__F4 Metabolic mechanisms of macrophage polarization ACLY NLRP3 PMC8348138__F5 Transcriptome-Based WGCNA Analysis Reveals Regulated Metabolite Fluxes between Floral Color and Scent in Narcissus tazetta Flower POR IPP HEL-S-62p C2 PMC3541196__F3 Dysregulation of the cell cycle pathway during tumor progression CCND3 TFDP1 CDKN2D CDKN2B CCNH RB1 RBL1 CDKN2A CDK6 CDKN2C CDK7 CCNE1 CDKN1A CCND2 CDKN1B CDK2 CCNB1 CCND1 CDK4 PMC2997006__F1 Tor pathway in the model fungi Saccharomyces cerevisiae and Schizosaccharomyces pombe RHEB TSC2 TSC1 PMC9545774__F1 Hypoxia in the tumor microenvironment and targeted therapy BNIP3 ADAM10 MICA MTOR PMC6703710__F10 Simplified model illustrating PDGFRA functions in elastogenesis EGF TGFA BTC PMC6767864__F2 IFN-λ4 Conundrum: When a Good Interferon Goes Bad IFNLR1 IFNAR2 USP18 IFNA4 ISG15 JAK1 TYK2 PMC5805379__F3 Renaissance of complement therapeutics CR2 C4A CR1 CP PMC6491460__F2 Modes of MUC1 control of cellular inflammatory signaling pathways MAVS NLRP3 TLR3 TLR4 MUC1 TLR7 MYD88 PMC4859429__F2 Classical and non-classical roles for pre-receptor control of DHT metabolism in prostate cancer progression SRD5A2 HSD17B3 STAR UGT2B15 HSD17B6 CYP17A1 HSD17B2 HSD17B10 AKR1C2 AKR1C1 UGT2B17 PMC4683091__F2 Position-dependent regulation of cell fate in the preimplantation embryo: known and hypothetical mechanisms CDX2 AMOT NF2 RBPJ TEAD4 PMC8027073__F8 TREM2 and CSF1R interaction in microglial survival TREM2 CSF1 CSF1R PMC3837458__F1 Triacylglycerol synthesis and acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes DGAT1 DGAT2 HEL-S-5 PMC8013721__F1 Summary of radiation-induced oral mucositis pathogenesis MMP3 IL1B PMC5071109__F4 Cell-free Xenopus egg extracts for studying DNA damage response pathways TOPBP1 ATR REV1 ATRIP RAD17 PMC7508719__F4 The KEGG “TGFB Signaling Pathway” showing differentially regulated genes for the Alizarin (+) treatments (TCPS_OS, PCL_NF, PDLLA_NF) LTBP1 BMP6 COMP THBS1 ID2 FST THBS2 CDKN2B ID1 DCN PMC10819970__F8 Engineering CXCL12 biomimetic decoy-integrated versatile immunosuppressive nanoparticle (VIN) for the management of overactivated brain immune microenvironment CXCL12 CGAS MSC ARG1 CXCR4 PMC3513983__F3 Major signaling pathways regulating RSV-induced NFKB and IRF activation in airway epithelial cells TBK1 MAVS TLR3 TANK IRF3 PMC4609655__F6 MAPK signaling pathway TES MAX ECSIT EGF FAS CD14 TNF TRAF6 DAO FLNA MOS NF1 NLK GRB2 BDNF TRAF2 PMC64856__F9 Network of metabolic pathways leading from Suc (orange, top left) to the volatile phenylpropanoids, phenylpropenes, and terpenoids formed in EMX-1 basil peltate glands (outlined with yellow backgrounds) IPP CAD HP PPY PMC3079294__F5 SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition RAD18 PCNA PMC5561723__F2 To identify coherent networks of genes influenced directly by smoking, we examined the potential interconnections of the 310 genes identified in the genome wide methylation analysis using PPI information in the STRING database ZAP70 TSHR SMG6 RCC2 BRCA2 CBX4 GNG12 PTGDR2 NEDD9 HEL-S-308 PER3 RARA NR1B3 RALA ADCY9 ZNF217 LPP ITPK1 RPTOR TRIO ETS2 TBCD LDHB SKI GATA3 ME3 CD44 HNRNPF HEL-S-47e EXOC2 ENO3 SAFB NFE2L2 PMC6073700__F5 GHR-JAK2-STAT pathway inhibition mediated by PTP-1B, SHP-1, SHP2 and SIRPA1 SOCS1 STAT3 GRB2 PMC4547762__F4 Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes PSMB6 MAVS KDM5B NAMPT MMP9 MPO IARS2 POSTN CORO1B TRIM25 C9 HEL110 FHL1 ELANE PSIP1 LCN2 PMC5796892__F11 Schematic representations demonstrating the role LdISP2 in the modulation of host response MASP1 MASP2 C2 C1S PMC6073700__F2 The SOCS proteins mechanisms of GHR-JAK2-STAT pathway inhibition SOCS1 STAT3 SOCS2 SOCS3 PMC6073700__F1 Activation of the growth hormone receptor and its signal transduction STAT3 ECD PMC8287682__F9 CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity POR CMTM7 MTOR PMC2635020__F1 CATHEPSIN D – MANY FUNCTIONS OF ONE ASPARTIC PROTEASE BAX NFKB2 PMC4322534__F3 Signalling networks in mouse and human iPS cells KLF4 STAT3 LIF SOX2 GRB2 MTOR PMC6405828__F2 TYRO3 signaling pathway TYRO3 CCND1 PMC4820821__F1 Hh signaling pathway EVC2 EVC KIF7 BOC SUFU PTCH1 SMO GAS1 PMC7392229__F6 Effect of compound kushen injection on cancer cells: Integrated identification of candidate molecular mechanisms DBF4 CDC20 PCNA STAG1 SMAD2 SMAD4 MYT1 PLK1 ORC3 SKP2 ORC2 CDK6 CDK7 CDK2 MDM2 CDK4 PMC3729906__F1 Molecules examined by immunohistochemistry CCND3 SYK GATA1 IMP3 NFATC2 JUNB MAL ICOS PLCG1 FYN HEL-S-171mP ITK UNK LCK PMC7874053__F4 Ingenuity Pathway Analysis (IPA) results for candidate genes of LGS or LGS-like epilepsy CHD2 SYN2 NPS VAV3 LRAT ANGPTL2 TBC1D8 H2BFM KRAS SHANK3 NRG2 SCN10A UHRF2 CALCRL PELO ADRA2B SLC25A39 RGS4 SNTB2 PMC8480016__F8 Identification of miRNAs-mediated seed and stone-hardening regulatory networks and their signal pathway of GA-induced seedless berries in grapevine (V. vinifera L.) TF GID8 HEL-S-5 AIP ARF4 POLE PMC12013426__F2 Mechanisms of gut microbiome delaying cancer progression NR1i1 HOPX TNFRSF1B NOD1 CCL5 MMP9 MTOR PMC12013426__F1 Mechanisms of gut microbiome inhibiting the initiation of cancers BAX SP1 IL12A TLR4 CXCL16 TLR5 DFNA5 CTNNB1 PMC7754005__F3 Down‐regulated differentially expressed genes participated in PI3K‐Akt signalling pathway. Red: differentially expressed genes down‐regulated; green: PI3K‐Akt signalling pathway gene RHEB TSC2 BAD BCR RXRA MEI1 RBL2 PTEN MDM2 MTOR RAC1 EIF4E PMC7663135__F3 Endo-lysosomal system is a complex pathway that is vital to countless processes in the cell, and its dysfunction results in the hallmarks of many diseases ROS1 ATG16L1 TFEB HEL-S-11 EEA1 PMC7754005__F2 Up‐regulated differentially expressed genes participated in PPAR signalling pathway. Red: up‐regulated differentially expressed genes; green: ppar signalling pathway genes LPL UBC AQP7 UCP1 HEL-S-28 PLTP CPT2 PMC11854358__F11 Hypothesized mechanistic diagrams for the effect of PFESA-BP2 exposure on EGF signaling and JAK/STAT signaling based on previous supportive studies EGF JUN EGR1 SHC1 EGFR NFKB1 PTPN1 SOCS2 GRB2 MTOR CEBPB PMC3972679__F2 Apoptotic pathways induced in beta cells in type 2 diabetes BAX BAD NLRP3 IL16 IAPP PMC3972679__F1 The two pathways of apoptosis BAX FADD PMC10616926__F1 Schematic drawing of the major neuroprotective signaling pathways regulated by ghrelin and GHS BAX CD36 BCL2 PMC8257727__F1 Signal transduction cascades mediating cisplatin-induced apoptosis (for details see in the text) BAX ATF3 ATR MEI1 CDK2 ATM ATF4 MDM2 TBP PMC8257727__F3 Signal transduction cascades mediating taxane-induced cell death BAX PCNA ATG5 PMC2893101__F3 Apoptosis Signalling network BAX TRADD BCL2 FADD PMC3534691__F8 Neuregulin Facilitates Nerve Regeneration by Speeding Schwann Cell Migration via ErbB2/3-Dependent FAK Pathway ERBB3 ERBB2 SRC PMC5381904__F2 Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability AURKA CDK6 PDK4 AURKB PRKAA2 APC CDK4 PMC8187289__F1 CRISPR-Cas9 delivery TLR9 TLR8 AIM2 TLR7 PMC5428490__F2 Transcriptome pattern differs between two oil biosynthesis tissues in oil palm LPA FAS DGAT1 PPT1 HEL-S-162eP GPT2 PC PMC7261837__F8 Anti-inflammatory responses of circumdatin D STAT3 TRAF6 MYD88 PMC12188246__F7 Evaluation of the WNT signaling pathway components in an expanded BMP-SOX9-WNT Turing network SOX9 BMP2 SULF1 PMC2312359__F4 Composite list of expressed genes and enriched transcription factors implicates specific regulatory networks JUND MAFG HIF1A ATF2 RXRG MYC NFIL3 NFE2 E2F4 E2F3 E2F6 MAF SP3 KLF9 SOX18 ATF1 HES1 NR1i1 NPAS2 BATF REST SP1 ASCL2 FOS TCF3 GRB7 RXRA NFYC EGR2 NCL MAX TF HEY2 NFKB2 CREM FOSL2 KLF16 NR3A2 MSC NR1A2 TFDP2 RXRB MXI1 JUN JDP2 EGR1 E2F2 RFX1 MEF2D RORC NFYA ERBB2 CREBBP PMC5117493__F6 Signaling pathways associated with differentially expressed proteins as identified by Pathway Studio HEL32 tmp_locus_29 WAS PMC4726722__F2 Nrf2 in the metabolism of rapidly proliferating cells MTHFD2 HEL107 ME1 HEL-S-26 PMC6829482__F7 The role of MyoF during skeletal muscle development MYOG MYOF APC CTNNB1 PMC3400831__F5 PGI2signaling pathways in VSMCs COX2 ARHA SKP2 PMC9019785__F9 Proprietary Medicines Containing Bupleurum chinense DC. (Chaihu) for Depression: Network Meta-Analysis and Network Pharmacology Prediction MAX TRO FAS TRADD NF1 NLK TNF FLNA TRAF2 PMC4788585__F8 The EGF Receptor Ligand Amphiregulin Controls Cell Division via FoxM1 FOXM1 EGFR AREG CCND1 PMC5817861__F2 Cell signaling pathways induced by Src kinases STAT3 MTOR SRC PMC8909308__F5 Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection BAX BAD CYCS BOK DIABLO PMC8909308__F4 Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection SOCS1 BAX CAST FAS PSMB8 STX12 MAK IRF9 GIP IRF1 FOS IFNG F9 PMC2856809__F3 Dual MAG receptor model LINGO1 ARHA PMC7563540__F2 Exosome biogenesis and release CD44 CD9 CD82 TSG101 CD63 PMC11049850__F3 Molecular mechanisms of LPS bacterial interaction with dental stem cells DMP1 TLR4 IL6 MYD88 PMC9161355__F1 Non-Coding RNAs Delivery by Small Extracellular Vesicles and Their Applications in Ovarian Cancer CD81 CD9 CD82 CD63 PMC10239924__F1 Raptor in lymphocytes differentiation and function RHEB MLST8 TSC2 TSC1 CAMKK2 FOXO1 FOXO3A MTOR DEPTOR PMC7098264__F1 ApoE Isoform Specific Effects in AD VLDLR APOE LDLR ABCA1 PMC9020986__F4 Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies CCR2 CCR7 IL2 GATA6 TIMD4 PMC8299307__F6 Schematic diagram demonstrating the novel signaling pathway involving EGFR–TRPM7 interaction in VSMCs EGF TRPM7 EGFR PMC3238295__F5 Bridged pairs and shared edges between 2ROs in the apoptosis pathway BAX CASP9 BAD CAD CASP8 MEF2B BNIP3 BNIP3L PROKR1 NAIP BCL2L1 CASP3 BCL2 BMF HRK CASP10 BIK FADD PMC8337009__F4 ICN: extracting interconnected communities in gene co-expression networks MAX MAK APMAP EN1 ASIC2 APP TRAF2 PMC2075101__F1 5-HT2A receptor agonists cause activation of GAq/11 proteins which in turn activate the second messenger enzyme PLC STAT3 RGS7 JUN FOS PMC4382094__F5 Na+/H+ Exchanger Isoform 1 Induced Cardiomyocyte Hypertrophy Involves Activation of p90 Ribosomal S6 Kinase EMD GATA4 PMC8299478__F1 Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients LOX COX1 PMC7254656__F2 Main signaling pathways involved in CD19-BBζ T cells and CD19-28ζ T cells PMC3573348__F3 Ingenuity Pathway Analysis (IPA) of genes differentially expressed in LRECe vs STAMBP KLHL20 SNRK IQGAP1 SMAD4 KHDRBS1 STRN3 PPP2R5E KIF23 U2AF2 E2F4 NDUFA3 SLC25A1 KLF10 NR5A2 CASC3 ITIH4 RPL31 RPL7A PTPN11 FOXN3 HMGCS1 PRKCI NR2A1 CAMK2D PMC3573348__F5 Ingenuity Pathway Analysis (IPA) of genes differentially expressed in ECb vs SSR1 RAP2B CSNK2B RPS16 RPL5 TRAF4 RPS3A MME USP4 HEL-S-2a USP25 RPS6 UBC SFPQ EIF3A RPS27A BNIP3L MED1 PABPC1 EIF4E UBE2V1 MYOG TAF1 GTF2B UGT2B4 HSPA4 PTGES3 PMC2374452__F5 Molecular pathways of rheumatoid arthritis-related cartilage destruction as reflected by the in vitro model COMP MMP12 SMS MMP10 CXCL1 CCR6 THBS2 CCR2 CR2 CXCL2 CXCR4 CXCL3 PMC6872668__F8 Increased Smad3 and reduced Smad2 levels mediate the functional switch of TGFB from growth suppressor to growth and metastasis promoter through TMEPAI/PMEPA1 in triple negative breast cancer SMAD2 PTEN PMC2882531__F1 Retinoids for Treatment of Retinal Diseases RPE RDH8 LRAT RPE65 RDH5 RDH12 ABCA4 PMC6783844__F1 The illustration of human IgG1 structure with N-glycan attached at Asn297 site in the CH2 of the Fc region GAL HEL-S-62p CS PMC7507029__EV5 Graphical summary of LRP6‐YAP signaling pathway LATS1 OGT LATS2 LRP6 PMC8695855__F1 Pharmacological Applications and Action Mechanisms of Phytochemicals as Alternatives to Antibiotics in Pig Production CSA2 TLR4 SIRT1 PMC9335103__F4 Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS ARHGAP1 TAPBP SLCO4C1 SLC1A3 ATP6V1A ZBTB1 SUPT5H SYCP3 ADM2 SIGLEC10 NR1i1 FAT10 LR8 ADAM19 FLNB SLC4A4 ERBB3 FMN1 TMLHE TCEA3 OGDH ADRB2 ADRB1 TIMD4 PIGR ITGB5 TF RRN3 CD27 IGFBP2 KDSR GLRX SGPP2 FGF7A ZC3H12D NIPAL1 DENND2D LIPH CLU CYB561A3 SNAPIN SYCE2 SH2D1B JAG2 FBXO34 MPHOSPH8 CSTA HLA-DQB2 NEUROD1 HEL-S-7 NIPA1 DMBT1 RAVER2 IGF2 RAC1 KITLG ENTPD3 CHI3L1 MMP27 ENPP2 CD8A CD3G CD3D PCBD1 OAZ1 VLDLR FACL4 CNGA1 CTSS PPFIA2 HCA112 TRAT1 GATA6 PLA2G7 CYLD THEMIS TNFRSF9 LILRA4 RPE ZC3H12A HSD3B1 PIGL CXCR5 TOX SND1 LMNA HSD17B4 HEL-S-301 SURF1 CD82 TRAFD1 NCF1 DCTN5 GP1BA CSF2RB CASP5 TLR8 TPD52L1 BIRC3 MSMB DACT1 CD2 PLEKHG3 RNASEL UBE2D1 MED22 DIPLA1 NFKB1 SLC39A8 TAAR8 PMC12249970__F5 Activation of AhR by kynurenine, leading to the differential modulation of T cell subsets IFNG KY AHR CYP1A1 PMC12249970__F4 The AhR in modulating adaptive immune responses STAT3 AIP AHR FOXP3 PMC12249970__F7 AhR and JAK/STAT pathway crosstalk in immune regulation IFNG STAT3 MAP3K7IP1 COX2 IRAK3 CCR6 IL4 AHR SOCS3 JAK1 TYK2 PMC2885902__F2 Mitochondrial biochemical pathways that are involved in KATP-independent GSIS FAS CIC PC ME1 PMC4311405__F5 Deregulation of signaling pathways and transcription factors LTBR KEAP1 EGFR PTEN IGF1R TRAF3 MYC CTNNB1 RB1 CDKN2A CDK6 FGFR1 CCND1 CASP8 B2M TP63 NFE2L2 ERBB2 FAT1 FGFR3 AJUBA HLA-B BIRC2 HLA-A FADD PMC3104248__F3 Signaling molecules implicated in epilepsy (see the text for the detail) CDC2 EIF4B BAD PIM1 IRS1 RHEB TSC2 PKD1 TSC1 FOXO1 CDK2 MDM2 CCND1 PMC3104248__F2 Genetic mutations of signaling molecules implicated in mTOR pathway (red Xs) STRADA RHEB PMC3104248__F1 MTOR signaling pathway RHEB TSC2 TSC1 GSK3B IRS1 PMC8132044__F1 What does elevated TARC/CCL17 expression tell us about eosinophilic disorders? SOCS1 STAT1 IFNGR2 IFNGR1 RAF1 IRF4 CCL17 PMC3274456__F3 Lipopolysaccharide (LPS)-dependent and nuclear factor (NF)KB-mediated activation of proinflammatory cytokines TLR4 CD14 TRAF6 LBP MYD88 PMC4588138__F1 Schematic of opportunities for host-directed therapies modulating eicosanoid balance COX1 TNF PMC4252069__F6 Identification of MicroRNAs Linked to Regulators of Muscle Protein Synthesis and Regeneration in Young and Old Skeletal Muscle RPTOR RICTOR IGF1 FOXO1 EIF2S2 EIF3A EIF5 AAG1 MTOR EIF4EBP2 EIF4E PMC4160334__F1 Receptors and signaling pathways involved in proliferation and differentiation of Sertoli cells DMRT1 BAX HBEGF NR3A2 CDKN1B BCL2 SRC CCND1 PMC8241768__F1 Molecular Genetics of Marfan Syndrome SMAD2 SMAD4 SKI PMC3573348__F2 Ingenuity Pathway Analysis (IPA) of genes differentially expressed in LRECb vs ZCCHC8 BRD4 JKAMP UTP18 SIX2 SUPT5H IL22RA1 CASR CTCF SH3BGRL2 POSTN NFE2 ARID5A CUTC SLC25A40 ZBTB39 NR5A2 STARD10 PWP1 FGFBP1 SRP54 TMEM208 TCF12 SCFD1 TRIP11 RBM15 ISOC1 RPS27A FGF10 PC4 DUSP11 P2RY14 DDB2 TAF1 GTF2B NR2A1 GUGU HSPA4 CYP2C9 SSR2 PMC9479759__F5 Therapeutic potential of WKYMVm in diseases STAT3 CD9 IRS1 IL1B PMC9479759__F3 Therapeutic potential of WKYMVm in diseases TFEB FPR2 ISG15 CD68 PMC8571357__F7 PER2 mediates CREB-dependent light induction of the clock gene Per1 PER2 PER1 CRTC1 PMC4223419__F1 Cellular pathways of prostaglandin (PG) metabolism PTGIS HPGD PTGES3 PTGS1 PTGES PTGS2 SLCO2A1 AKR1B1 PMC6442998__F6 Potentiation of imatinib by cilostazol in sensitive and resistant gastrointestinal stromal tumor cell lines involves YAP inhibition LIX1 PDE3A SFPQ KIT PMC2735047__F3 Graft-versus-Host Disease TH APC PMC8993567__F4 Cellular and Molecular Mechanisms Involved in Hematopoietic Stem Cell Aging as a Clinical Prospect SOX17 CD48 CD79B ROS1 EGR1 TXNIP CD27 MTOR XAB2 CD47 RHEB TSC2 CD74 CD37 ARHGEF12 HEL-S-171mP CD160 AP3B1 CD63 IL1B PMC5618564__F2 FAK-deleted keratinocytes demonstrate alterations in key mechanotransduction and collagen signaling pathways TRIM72 PMC4396493__F2 No quiet surrender: molecular guardians in multiple sclerosis brain KEAP1 MAF PMC7464415__F11 TLR3-dependent activation of MyD88 signaling: TLR3 activation triggers endogenous ligands of TLR2 (HMGB1 and Hsp60) via the usage of the MyD88 signaling pathway HMGB1 IL18 TNF PMC10375937__F1 Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway TLR4 TRAF6 IRAK4 MYD88 PMC4207397__F1 Dicarbonyl stress and RAGE signaling VCAM1 GLO1 PMC7998595__F1 Autophagy pathway in podocyte ATG16L1 ULK1 JMY SQSTM1 MTOR TSC2 WHAMM CAMKK2 ATG12 FOXO1 FOXO3A TFEB BCL2 ATG5 PMC7338473__F1 Insulin receptor endocytosis in the pathophysiology of insulin resistance CDC20 CSH2 PMC4295834__F4 Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials DCC VEGFA CXCR4 PMC7325485__F1 The dominant control mechanism by which Nrf2 activity is regulated occurs through its association with the E3 ubiquitin ligase KEAP1 and subsequent ubiquitination and proteasomal degradation HMOX1 GPX2 GSTM2 PGAM5 GCLC MAF SQSTM1 PALB2 PMC8771834__F3 Insight of Autophagy in Spontaneous Miscarriage CXCL12 ATG9B TFEB CTBS SHH VEGFA PMC5349319__F3 Summary of identified microRNAs that target key proteins of autophagic pathway for regulation of autophagy ATG101 ATG10 ATG3 ATG12 ULK1 UVRAG AMBRA1 SQSTM1 ATG5 ULK2 PMC4742115__F5 Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development EFNB1 APOE CLEC2D SI TCF21 SFRP1 PMC10216337__F6 Schematic representing the suspected roles of and molecular pathways involving MeCP2 in prostate-cancer progression TRIM24 GADD45A PMC10216337__F2 Schematic representing the suspected roles of and molecular pathways involving MeCP2 in colorectal-cancer progression KLF4 SOX2 METTL14 METTL3 IGF2BP2 SPI1 PMC10216337__F3 Schematic representing the suggested roles of and molecular pathways involving MeCP2 in pancreatic cancer CDH2 LIN28B LIN28A SOX2 FURIN PMC3684135__F1 Transforming growth factor B (TGFB) signaling pathway in hypothermia LTBP1 STAT3 SKIL EGF SMAD9 SMAD1 DKFZp781O1323 TGFB1 SMAD2 SMAD4 MAPK9 RUNX2 MAPK3 TGFBR1 TGFBR2 BAMBI ITGB6 FOXH1 IFNG INHBA FST NOG BMP4 FKBP1A THBS1 JUN LIF SMAD6 TGFBR3 TNF FOS SKI SPP1 RUNX3 ENG NFKB1 CREBBP JAK1 PMC6167486__F1 Proposed roles for CXCR3 and its ligands in melanoma CXCL9 CXCL11 CXCR3 APC CXCL10 PMC5618489__F7 Dynmics of starch biosynthetic pathway during development stages of pericarp and endosperm DAP ENPP1 GPT PMC3228910__F2 Expanded representation of the KEGG pathway "colorectal cancer" LPA BAD MSH2 LAT APC PMC8093597__F2 Immunological and physiopathological approach of COVID-19 in pregnancy TMPRSS2 SELL APC ACE2 PMC7226782__F4 GSK-3/Beta-catenin in sensing of cytosolic DNA by the cyclic GMP–AMP synthase (cGAS)/STING pathway TBK1 CGAS IRF3 CTNNB1 PMC4888568__F1 Model of insulin signalling pathway TSC2 TSC1 PI3 PTEN GRB2 SRC IRS1 PMC7707088__F1 Function and therapeutic potential of G protein‐coupled receptors in epididymis CFTR ERG GPR64 PMC5597136__F4 Known and recovered GRN for cell cycle pathway in yeast Saccharomyces cerevisiae CDC20 FAR1 CDC6 CLN3 PMC11806845__F1 Mitochondrial membrane permeabilization results in mtDNA leakage BAX GSDMD FH PGAM5 SNX9 PMC6383445__F2 Roles of PARPs in the immune response after pathogen invasion PARP12 XRN1 PARP14 PARP15 PARP1 PMC5134704__F1 The plasticity of EZH2 in regulating MMP-mediated invasion pathway SUZ12 FOXM1 EED EZH2 PMC3053348__F7 The Danger Signal S100B Integrates Pathogen– and Danger–Sensing Pathways to Restrain Inflammation TLR3 TLR9 S100B MYD88 PMC8870198__F1 SMAD4 Inactivation in Epithelial–Mesenchymal Plasticity of Pancreatic Ductal Adenocarcinoma: The Missing Link? CDC42 TF SMAD2 SMAD6 SMAD4 ARHA MTOR PMC4730629__F7 Reactive oxygen species (ROS) pathway in bamboo TF MYB ERF PMC9488800__F4 Multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease LTB PGP LTA IL8RB PMC4599578__F6 Cancer-promoting GSNs in A) D-SWCNT, B) D-MWCNT and C) ASB neoplastic-like transformed SAECs PPARG CSF2 CCK KIDINS220 MYC SKP2 SPI1 FOS CD44 MDM4 ATF3 INHBA tal-1 COL18A1 SNCG IKBKB MMP2 ATM ENPP2 PMC11806845__F6 Primary cytoplasmic DNA sensors activated by cytosolic mtDNA RIPK3 TBK1 CGAS PINK1 ZBP1 NLRP3 TLR9 AIM2 IRF3 MYD88 PMC11806845__F5 Dysfunction in mitophagy is closely related to mtDNA leakage TFAM BAX VPS35 PINK1 VMP1 FUNDC1 TNF XBP1 PMC8351231__F2 The Hippo signalling pathway AXL NF2 AREG SRC MYC VGLL4 CDCP1 PMC8351231__F1 Different signaling pathways involved in resistance to EGFR tyrosine kinase inhibitors (TKIs) driven by Protein Kinase C delta (PKCD) and receptor tyrosine kinase recycling FER EGFR COPA CDCP1 PMC7105880__F1 Outline of the pathway of eicosanoid synthesis from arachidonic acid LTA COX1 COX2 PMC7793832__F2 NLRP3 inflammasome activation following non-canonical inflammasome activation GSDMD NLRP3 IL1B PMC6851264__F8 Working model of the pathway to maturation of invadopodia when cancer cells are stimulated by transient tugging forces PAK1 LIMK1 RAC1 PMC5260963__F4 Protein interaction map GALNT1 MYL10 FOLH1 DHFR NCF1 VCAN MBL2 MYOM2 ARHGEF11 MAGI1 TFPI F10 ALG13 ERBB2 BCL2 ISG15 MB LMOD1 STMN2 C4B_2 TMPRSS6 PMC4968084__F3 Unlike the 20S proteasome, the subunits of the Immunoproteasome lack functional EpRE binding domains, and so cannot be regulated by Nrf2 IFNG STAT1 JAK1 PMC8148124__F3 Calcium and Redox Liaison: A Key Role of Selenoprotein N in Skeletal Muscle ELF2 XBP1 PMC5487386__F2 Signaling pathways in innate recognition of fungal pathogens and differentiation of CD4+ T helper cells CD40 SYK IFNGR1 RAF1 NCF4 IRF3 IRF7 IL6 TRAF6 IRAK4 BCL10 NLRP3 TLR4 STAT4 CARD9 IL12RB1 PMC3148653__F3 Network of TP53-regulated genes HEL164 TNFRSF10C TMEM97 ACSL3 UBE2C TNFRSF10B NCAPG HMMR NEK2 CENPE CDT1 CCNA2 GTSE1 EZR GDF15 PRC1 CCNB1 TOP2A HMGN2 MSH2 POLE2 RRM2 PLAUR KNTC2 PTGS2 MMP9 IL6 MAD2L1 SPP1 PHLDA3 HBEGF CDKN1A FOSL1 CHEK1 MCM6 PMC3148653__F4 Network of HNF4A-regulated genes C11orf68 VEGFC HMGB1 NR1H3 AQP3 ACO2 NUF2 HSPA4L NR1D1 IVNS1ABP ATF2 CYP1B1 PTPN13 PMS1 YPEL3 GPX2 MED18 FOSL2 NR2A1 PAF1 NFE2L3 ELF3 PMC7933770__F2 PPI network of the DEGs, and the expression levels of the hub genes in PDAC tissues and normal tissues MMP14 PDK4 EPHA4 PMC3958334__F3 Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila MFAP1 MYB AGO1 HEL-S-310 DROSHA RAC1 FNTA RPS8 MED31 RPS3A RPS29 SLMAP MOB4 CDK12 RPS3 NUP153 CDC37 SPX LSM4 RNPS1 PMC11359136__F2 HCMV regulates the classical Wnt/Beta-catenin signaling pathway APC LRP5 LRP6 CTNNB1 PMC7969743__F3 Emerging role of ferroptosis in intestinal disease CDKN1A DPP4 SLC7A11 GLS2 PMC5483997__F1 Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition SMAD1 SMURF1 DKFZp781O1323 SMAD6 SMAD4 RHO SMURF2 ID1 PMC3932947__F7 En2 modulates IGF1’s pleiotropic effects in GNPs, potentially through altered S6 kinase activation EN2 IGF1 IGF1R PMC11359136__F3 HCMV regulates the Notch signaling pathway STAT3 HEY2 SOX2 ADAM10 PMC4420923__F10 Molecular mechanism for SGK1 signaling and cell survival GSK3B MEI1 PMC9031331__F4 Integrated Analysis of the miRNA-mRNA Regulatory Network Involved in HIV-Associated Neurocognitive Disorder EFNB2 CXCL12 MAFK DCC LAT NRP1 PTPN1 BMP7 PRKCZ ARHA EFNA1 HRAS NTNG1 FYN ALK PAK1 SHH RRAS RND1 PMC7290906__F1 Polyplex internalization pathways, driven by mediators, cytoskeleton movements, and GTPase signaling CDC42 PAK1 ARHA PMC8431517__F10 Network Pharmacology Study on Morus alba L. Leaves: Pivotal Functions of Bioactives on RAS Signaling Pathway and Its Associated Target Proteins against Gout PRKCA PLA2G2A PMC1852238__F1 Role of the glutathione pathway and ABC-transporter family in drug elimination and defense from ROS-mediated oxidative stress ABCC1 ABCG2 GPX1 ABCB1 PMC8755543__F7 Mechanism diagram of KDM4A-AS1 regulating the degradation of AR/AR-Vs USP14 MDM2 PMC11468005__F1 PI3K/AKT/ mTOR signaling pathway TSC2 TSC1 PTEN PMC6557399__F1 HMG-CoA reductase pathway CDC42 RHEB RHO PTP4A3 PMC4131144__F5 Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model ACLY HEL60 PFKFB1 FH ACO2 HEL-S-133P HK2 ACACA ME1 PDK2 SDHA GLUD1 ACAT1 GPD2 OGDH HEL-S-32 HEL-S-26 PMC6161371__F3 Cooperation between c-Myc and YAP/TAZ or HSF1 cofactor (a) Phosphorilation of YAP/TAZ by Hippo signaling pathway promotes cytoplasmic localization and ubiquitin-mediated degradation LATS1 LATS2 HSF1 PMC9519344__F4 Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes ATG10 ATG12 BNIP3 ATF4 ATG5 PMC7533892__F3 Consequences of IDH1/2-related cancer metabolism for redox homeostasis SIRT3 HEL-S-62p ME2 HEL-S-32 ME1 HEL-S-26 NNT NOX4 PMC9519344__F3 Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes ATF4 EIF2A PMC7098128__F2 Extracellular DNA in blood products and its potential effects on transfusion TBK1 TLR9 IRF3 IL1B PMC7533892__F5 2HG interference with the mTOR pathway and collagen maturation KDM4A PLOD1 RICTOR PLOD3 MTOR P4HA1 DEPTOR PMC6129574__F5 Metabolic pathway influenced by patulin and Protein interaction network of Kcr proteins RPS15 RPL32 EMG1 RPL38 RPL30 UBA2 CPA2 CLU SRM RPL29 NOG RPL28 TEF UTP23 RPF1 RPL37A RPS2 RPF2 NOB1 CAP2 RPL3 VPS35 RPS20 SLA2 SEC63 RPN2 tal-1 FPRL2 HEL-S-68p HEL-S-49 PPT1 HAS1 RPN1 SKP1 FES RPL9 RET NCL PMC7698938__F5 Mechanisms of therapeutic effects of Cinacalcet on CKD-MBD CRP SOST PTH PMC8537491__F2 Cellular Signalling and Photobiomodulation in Chronic Wound Repair SMURF1 GRB2 MTOR SMURF2 ID1 EIF4E PMC6859487__F1 Basic metabolic pathways used in T cells CD36 HEL-S-162eP MPC1 MTOR MPC2 PMC9519344__F5 Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes TFAM ATF4 XBP1 PMC8962202__F3 CIGB-300-Regulated Proteome Reveals Common and Tailored Response Patterns of AML Cells to CK2 Inhibition CCND3 SMAD1 MRPS16 ATRIP ANAPC10 MRPL52 KGD4 GNB2 LIMK1 RBL2 MRPL42 TMEM63A PIH1D1 MAPK14 TSPAN14 LRRK1 PIAS1 PMC8718819__F1 Rho GTPase signaling in rheumatic diseases CDC42 PRG4 STAT3 ICOS NOS2 TNC COX2 PAK1 MMP3 RHO MMP9 RAC1 PMC12179559__F3 Energy metabolism and signalling pathways involved in IMPDH2 FOXO1 APC GSK3B MMP2 IMPDH2 MMP9 MTOR TRAF6 CCND1 CTNNB1 PMC6104680__F6 Mechanisms of interaction between IL-6 and TGFB leading to fibrosis in SSc STAT3 IL6 JAK1 SRC TYK2 IL6R PMC10899349__F1 IGF1/IGF1R axis and its downstream signaling pathway IGF1 GSK3B BRAF IGF1R MTOR CTNNB1 PMC6686084__F1 An example of cellular nutrient–gene interaction mechanisms FAS SCD GCK PMC10203752__F3 Mechanisms of proanthocyanidins in treatment of HSP TLR4 TNF MYD88 PMC10489316__F10 Targets-pathways network CDC42 HEL-S-22 PPARG HEL-S-21 EGFR JAK3 GSK3B IGF1R CCL5 FGFR2 HMOX1 STAT1 RARA BCL2L1 CDK6 ADAM17 INSR F2 NR3A2 FGFR1 MMP2 MMP3 IL2 KDR SRC APAF1 NR1i1 HEL-S-72p NOS2 ERBB4 SELE CTSL CTSK PTPN11 MMP9 ARHA RAC1 PARP1 RHEB NR1C1 RAB5A HEL-S-130P CASP3 CDK2 LCN2 S100A9 HEL-75 PMC11174683__F3 Mechanistic map of signaling pathways associated with NPs for liver cancer treatment ETV5 CD44 GBP3 STAT3 BAX PCNA SHH MTOR CCND1 AXIN2 CTNNB1 PMC11943704__F5 Plasma Proteomics and Metabolomics of Aromatase Inhibitors-Related Musculoskeletal Syndrome in Early Breast Cancer Patients TF TFF1 KRT10 HEL-S-130P PGR EBAG9 KRT14 EGFR BCL2 SHE KRT19 PMC7265486__F1 Stratification and prediction of drug synergy based on target functional similarity BOC EGFR PMC5261008__F6 The multi-targeted STAT3 and TLR9 for aGvHD therapy STAT3 APC TLR9 PMC5914062__F2 Schematic model illustrating the relationship between glucose metabolism and radiation resistance STAT3 HEL-S-133P PMC4671345__F3 LIF protects cardiac myocytes by both genomic and non-genomic means STAT3 COX2 LIF GSK3B ARHA GRB2 PMC11629383__F3 POU5F1P1 and NANOGP8, two processed pseudogenes encoding functional proteins STAT3 FGF21 AREG SHE H1-2 PMC5928437__F9 miR-103/107 promoted ER stress-mediated apoptosis via the Wnt3a/Beta-catenin /ATF6 pathway in preadipocytes WNT3A BCL2 CTNNB1 PMC11629383__F2 Truncated yet functional NOTCH2NL genes IL4 NOTCH2 MYC PMC8616319__F3 Immune Components on Stem Cell and Dormancy in Cancer DKK1 CCL5 CCDC25 MMP9 CCL2 PMC12185661__F3 GPER signaling pathways TF HBEGF EGFR PMC8375100__F1 Kynurenine pathway metabolites in cerebrospinal fluid and blood as potential biomarkers in Huntington's disease IDO1 KMO IDO2 PMC5541669__F3 Recurrent architecture of tumour initiation, progression and drug sensitivity STAT3 SYK CD79B CD79A CARD11 IRAK1 MTOR IRF4 TRAF6 IRAK4 MYD88 STAT1 BTK BCL10 BCR JAK1 TYK2 PMC5919715__F8 PPI and miRNA-gene regulatory networks FZD5 PRICKLE2 FZD4 VANGL1 CCND2 WNT3A FRAT2 PLCB3 PPP3R2 WNT7B CCND1 SFRP1 PMC9284696__F2 Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration RGCC PEX5 CD99 KIAA0319 SIPA1 CAMKK2 PORCN BRI3 PRELP SYBU JUNB SERPINA3 PMP22 B4GALNT2 NUP62 RPS29 FAU HEL113 NKG7 ANKRD50 SNUPN HTRA1 FADS2 ETFA LCOR GREM1 KLF10 QRICH1 COXFA4L2 CEBPB RBM38 DAG1 COL1A2 CELF6 ZNF84 GRIPAP1 ERLIN1 SLC36A3 SLC26A1 MROH1 SLF2 MANBAL NPIPB6 HBA2 PKD1 GNE DCAF13 SUI1 DEFA3 PMC9284696__F4 Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration MAPK1 TGFBR2 KLF2 TGFB1 ACVR1B CCND2 FOXO1 FST SMAD2 SOCS3 FOS PMC8804296__F1 Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis GSDMD NLRP3 TNF IL1B PMC6899955__F1 Screening of Mtb virulence proteins that interact with proteins from macrophages RPIA PSD HEL-S-69p PMC8804296__F3 Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis BAX FADD PMC4884045__F1 Mammalian Hippo signaling LATS1 LATS2 ARHA NF2 TBX5 PMC3411424__F4 AlzPathway on Payao system COMP SI PMC3411424__F3 Binary-relation notation and key molecules of AlzPathway TIMP1 TLR4 NGFR APOE APP IL6 MTOR CTNNB1 PMC7054734__F9 CircNR3C1-Regulated Pathway in RPE CellsRed arrows indicate promotive function and green lines indicate suppressive function RPE PTEN MTOR PMC7855613__F4 Glycosylation in oncogenic signaling pathways EGF APC GSK3B SMAD4 CTNNB1 PMC7682655__F10 Diagram presentation of the molecular mechanism KDM3A PMC10957617__F3 Versatile Mechanisms of STING CGAS HK2 IRF3 SEC24C PMC4918597__F2 MiR-548, miR-27, miR-346, miR-218, miR-34a, miR-21, miR-22 and miR-29b promote the osteogenic differentiation of mesenchymal stem cells through Wnt/catenin, Notch, TNFA, TGFB/BMP signaling pathways APC GSK3B DKK2 NOTCH2 RUNX2 DUSP2 HES1 CTNNB1 PMC7688515__F1 Immunometabolic pathway during mycobacterial infection NR1C1 TFEB IL1B PMC5526991__F5 Extended Kegg Pathway for PI3K-Akt signaling TNC COMP BAD LAMA1 THBS2 THBS3 VTN PTEN IBSP CHAD TNR LAMB1 COL9A3 MDM2 VWF THBS1 LAMC2 COL9A1 LAMB4 RELN SPP1 XB LAMB3 LAMB2 THBS4 COL9A2 LAMA3 PMC3781192__F1 Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults SLC19A1 MTR PMC5834792__F3 Drug resistance in anaplastic lymphoma kinase‐rearranged lung cancer ERBB3 HGF TGFA ALK EGFR EML4 PMC12049683__F6 TMAO inducing cell ferroptosis TF SLC3A2 FTL STEAP3 GPX4 SLC7A11 PMC9454744__F3 Small Nucleolar RNAs and Their Comprehensive Biological Functions in Hepatocellular Carcinoma MDM2 FGFR2 PMC4791320__F2 Energy balance signaling, leptin and insulin interaction with possible ciliary genes RHEB STAT3 TSC2 SSTR3 TSC1 INSR LEPR POMC AgRP MTOR PMC12049683__F5 TMAO inducing cell pyroptosis BAX ALDH2 SDHB GSDMD NLRP3 DFNA5 PMC12049683__F4 TMAO inducing autophagic cell death ATG16L1 ATG12 ATF4 MTOR ATG5 PMC12049683__F3 TMAO inducing cell Apoptosis STAT3 NLRP3 CRYAA ATF4 XBP1 PMC3180702__F6 Transcriptional complexity of the mesenchymal-epithelial transition network LHX1 EMX2 PAX2 OSR1 FGF8 EYA1 FGF2 PMC10814071__F4 Regulatory Gene Network Associated with the Ameliorative Effect of Oat Antibacterial Peptides on Rat Colitis MTOR LPP SKI PMC5849426__F7 Putative model illustrating the interplay between RANK/NFKB-dependent and Hdac3-dependent control of mTEC development HDAC3 TEC NFIB SPIB EHF POU2F3 PAX1 PMC3641106__F8 Differential Use of TLR2 and TLR9 in the Regulation of Immune Responses during the Infection with Trypanosoma cruzi TLR9 PMC8703376__F2 Inositol Phosphates and Retroviral Assembly: A Cellular Perspective ITPK1 ITPKA IPMK IPPK MINPP1 PMC6958407__F4 Proposed model for modulations of Hippo pathway by PDEF LATS1 LATS2 YAP1 PMC8833440__F1 Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway S1PR1 SPNS2 S1PR3 SPHK2 S1PR2 SPHK1 S1PR5 S1PR4 PMC6345631__F1 Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae LATS1 MOB1A MOBKL1A LATS2 CAVIN1 TEAD2 TEAD3 TEAD4 PMC3865655__F1 Caveolin-1 is a highly versatile regulator of cell signaling GRB7 CSK SRC CCND1 CTNNB1 PMC8833440__F2 Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway S1PR1 S1PR3 SPHK2 S1PR2 SPHK1 RHO S1PR4 PMC6991676__F7 Hypothetical pathway related to the disease pathogenesis process RB1 CDKN1A MYC PMC7193445__F2 Examples of SLC mediated drug transport across the blood-brain barrier and in glioblastomas and neurons SLC22A5 STAT3 SLC7A5 PMC5067323__F1 Metabolic pathways associated with DA TH ALDH2 DBH PAH ALDH3A2 DDC MAOA PMC3907060__F4 Analyses of differentially expressed genes regulated by fasting in all three tissues revealing an involvement of p53 and Srebp signaling pathway ACLY FAS CREM ACACA MVK ACSS2 ACAT2 RXRA PMVK LPIN1 MVD FDPS IDI1 SESN2 HEL-S-44 PMC4346882__F3 Schematic depiction and overview of PI3K/AKT/PTEN signaling has been shown TSC2 TSC1 PTEN MTOR CTNNB1 PMC10253150__F6 Wnt signaling pathway, including the canonical pathway, the pathway associated with cell polarity determination (Wnt/PCP), and an increase in intracellular Ca2+ (Wnt/Ca2+), whose genes were significantly regulated in the ZG zone DVL1 NFATC2 PPP3CA MYC PPP3CC SOST CAMK2A CTBP2 PORCN DKK1 PRKCA CSNK2A1 SOX17 ROCK2 ROR2 APC DVL2 SFRP4 TCF7L2 FOSL1 PLCB1 MAP3K7 PLCB2 DKK4 PLCB4 PPP3R1 RYK CSNK1A1L PRKCB CSNK2B CTNNB1 CCND2 CTBP1 SENP2 DKK2 PLCB3 CCND1 NKD1 GPC4 JUN NKD2 NFATC1 DAAM2 TCF7L1 ARHA PPP3R2 CXXC4 INVS FRAT2 NOTUM CER1 DVL3 NLK NFATC3 LEF1 CAMK2G WIF1 PMC10253150__F7 Biogenic amine synthesis signaling pathway, whose genes were characterized by expression significantly regulated in the adrenal medulla ACHE TH PNMT DBH GAD1 AANAT ASMT DDC MAOA TPH1 HDC GAD2 PAH ChAT PMC3753466__F3 Skp2/Cks1 is induced by the TNFA/NFKB signaling pathway in nephropathy TRADD RELB SKP2 TRAF2 PMC4320441__F3 49 genes whose functional domains were changed by DAS exons EGF TGFA SHC1 EGFR KIT MTOR KITLG RHEB CDKN2A TSC2 EP400 HBEGF TSC1 ARHGEF12 ARAP1 MDM2 GRB2 PMC4269730__F5 Transforming growth factor (TGF)-beta signaling pathway TGFBR2 BMPR2 SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC8138183__F2 Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells STAT1 SP1 EGFR PMC8988234__F3 Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance SLC3A2 TYRO3 GPX4 PROS1 SLC7A11 PMC8988234__F2 Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance TF TFRC IPP LOX STEAP3 GPX4 LPCAT3 DHODH HEL-75 PMC9489416__F9 MCU Inhibitor Ruthenium Red Alleviates the Osteoclastogenesis and Ovariectomized Osteoporosis via Suppressing RANKL-Induced ROS Production and NFATc1 Activation through P38 MAPK Signaling Pathway CTSK ATP6V0D2 MCU NFATC1 TRAF6 RUNX2 ACP5 PMC2950025__F1 Models of mitotic exit in yeast CDC2 CIB2 APC NET1 PMC4234693__F2 Three Wnt-dependent pathways have been categorized: canonical Wnt/Beta-catenin and non-canonical Wnt/PCP as well as Wnt/Ca2+ pathways APC GSK3B ARHA CTNNB1 PMC4234693__F4 Influence of non-canonical Wnt signals on the MAPK pathway SOX9 APC GSK3B MMP3 MMP9 RUNX2 CTNNB1 PMC4234693__F3 Influence of canonical Wnt signals on the MAPK pathway CDC42 SOX9 WNT3A RHOB APC GSK3B ARHA CTNNB1 PMC4234693__F5 Influence of MAPK signals on the Wnt pathway SOX9 APC GSK3B CTNNB1 PMC3193426__F1 DSB repair pathways and SUMO RAD18 SMC6 PCNA SMC5 PMC4511863__F6 Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease STAT3 TREM2 NOS2 TYROBP TLR4 MS4A6A DOK3 MYD88 PMC5045138__F2 During homeostatic conditions, the Keap1 proteins binds with the nuclear factor Nrf2, inhibiting its translocation to the nucleus and the induction of the transcription of Nrf2-dependent reading frames KEAP1 MAF PMC7990372__F2 Illustration of the processes of iron uptake, storage, and efflux in the retinal pigment epithelium (RPE) cells TF TFR2 STEAP3 FTMT HFE HFE2 PMC4511863__F1 Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease IFNG LY96 MAP3K7IP1 IRF1 TRAF6 LBP MYD88 PMC8441048__F7 Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology HEL-S-44 PMC8292968__F2 Non approved pharmacological targets and interaction of selected profibrotic pathways in SSc myofibroblasts that are currently being evaluated in clinical trials LPA STAT3 MC1R IL13RA1 MRTFB MRTFA RHO JAK1 SRC NOX4 TYK2 PMC7072578__F2 Autoimmune response signatures for ovarian cancer MDK PHF20 SH3RF2 FUBP1 MYC PLK1 TXN CD74 CENPK HSPA2 NOP56 TMSB4X NACA TMSB10 SAA1 SMYD2 IGF2BP1 SERINC3 SERPING1 KDM5B ANXA2 UVRAG ORM1 E4F1 EIF4G1 BRCA1 PTBP1 MLF2 CTSO RNF38 HEL-S-49 ENO1 SESN1 PIGR HEL-75 HEL-S-22 TP73 CALU HEL113 TMEM97 PTEN TNFRSF10A HEL-S-276 CTNNB1 MDM4 SUMO1 KIF24 RFFL CEP170 MYH9 ZNF217 RBM38 RPTOR ACTBL2 NFATC4 LGALS3BP BAG1 STC2 RBFOX2 AGR2 YPEL3 PKD1 HEL-S-102 POU2F1 ARF4 CEP55 DNAJA2 PMC4783934__F4 Six miRNAs and their target genes that are involved in milk fat metabolism in bovine mammary gland LPL PDPN SYK UCP3 PTGS2 HADHB CD74 QK3 PTGIS HPGD EDN1 PRKAG3 PTGS1 ALOX15 ELOVL6 PMC6694157__F5 P53 signaling pathway (hsa04115) is extended in the weighted network ST14 KLKB1 AK3 CYCS AGTPBP1 CTSG FAIM SLC25A24 FUNDC2 SIPA1 USP40 INHA MIDN PTS DEHAL1 MDM2 MADD TBCC PFKFB4 SIAH1 ORM1 CRYAA CCNI MZF1 RBX1 AIG1 UHRF2 RNF38 SETMAR TP63 POLR3GL BCL2 TP73 PPM1D ATR HLA-DOB CD82 SFN PTEN HYI RHOBTB2 TLK1 PPBP RAB36 GADD45B ATM CINP KNG1 BNC1 ANKRD12 HLA-DMB BAX RHOBTB3 IGFALS SLC12A8 ZNF174 TMEM79 EI24 IRF6 AGBL2 DEDD RPRM CD160 PMC6590237__F1 Dorsal root ganglion (DRG) neurons branch out to the skin with transient receptor potential channel vanilloid 1 (TRPV1)/transient receptor potential channel ankyrin transmembrane protein 1 (TRPA1) and other receptors expressing NGF TRPA1 TRPV1 PMC4013405__F3 nAChR-mediated signaling in lung squamous cell carcinomas and adenocarcinomas EGF EGFR SRC PMC7445810__F4 Interactions between the hypoxia inducible factor (HIF) and circadian pathways PER2 CRY1 PMC4790729__F2 Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders BAD IGF1 GRB2 PMC4790729__F1 Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders RAF1 SOS1 PTEN GRB2 MTOR IRS1 EIF4E PMC2991085__F2 Stress-Activated Cap’n’collar Transcription Factors in Aging and Human Disease BACH1 KEAP1 MAF PMC2774738__F3 Specification of cell fate in the mammalian cochlea ID2 HEY2 ATOH1 SOX2 ID1 EYA1 FGF8 ID3 BMP4 FGFR1 JAG2 SHH FGF20 FGFR3 LFNG HES1 GLI3 HES5 PMC4179613__F3 MicroRNAs expression profile in CCR6+ regulatory T cells CBL FYN BCL10 LAT EPO LCK CDK4 PMC11914797__F5 BBR and its derivatives are involved in autophagy mechanisms CD44 MLST8 CGAS PINK1 ULK1 TFEB ATG14 MTOR DEPTOR PMC2965188__F2 Nrf2 cytoprotective signaling pathway RBX1 KEAP1 MAF PMC7833428__F6 Functional significance of activation of EGFR, IGF-1R, and B1-integrin receptor downstream signaling in wound healing EGFR IGF1R GRB2 SHE SRC PMC11914797__F2 BBR and its derivatives influence the mechanism of apoptosis BAX PMC5996891__F5 Homology modeling of Staphylococcus aureus phenol-soluble modulins (PSMs) PSMA4 PSMB2 PSMA2 PMC7833428__F4 Extracellular PEPD induced expression of the B1-integrin receptor and IGF-1R signaling proteins in control and “scratched” fibroblast models HEL-S-162eP IGF1R GRB2 SHE PMC8589992__F6 Proposed working model of FATP5-mediated effects on HCC cells CDH2 MTOR PMC3224200__F1 Contribution of chemoattractant GPCRs to glioma stem-like cell mediated tumorigenesis, invasion and angiogenesis express various GPCRs STAT3 EGFR CXCR4 PMC6335974__F1 Network displaying key genes involved in apoptosis, DSB repair, Fanconi anemia pathway and homologous recombination FANCD2 CASP9 ATR RAD51 BRCA2 CASP3 ERCC5 BCL2 ATM TERT FANCL TP53BP1 PMC3334602__F10 Putative signal transduction pathways regulating fruiting body development in C CDC42 CDK7 RHO PMC3774995__F2 Schematic representation of p30 functions TLR4 CDK2 ATM MYC PMC2792912__F6 Model of Six2 function during mouse pyloric sphincter development SOX9 BMPR1A BMP4 SI SIX2 PMC6989403__F8 PMEPA1a promotion of tumor progression is mediated by Hippo signaling LATS1 NEDD4 TMEPAI PMC6161810__F1 Wound healing, cellular regeneration and plasticity: the elegans way CDC42 CST1 MCU PMC8638406__F8 IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases IL17RC CXCL5 CXCL1 IL8RB PMC3221598__F3 Protease Regulation: The Yin and Yang of neural development and disease DCC APP SRC PMC8063444__F5 5-HT, produced by TPH2, regulates the serotonergic synapse pathway (a) and oxytocin signalling pathway (b) in the hypothalamus OXT EGF GNG13 GABRB2 EGFR PTGS1 TPH2 CAMK4 PMC6918647__F3 Network analysis using Ingenuity Pathway Analysis (IPA) among 4 upregulated (a: HMGB1, HOXA13, SREBF2, MECOM) and 3 downregulated (b: NCOA2, CSHL1, HDAC5) transcription factors and differentially expressed genes due to onset of ketosis postpartum SKIL NAPB TMEM97 ITGB4 EBP BMP7 SREBF2 PTEN TSC22D3 HEL-S-78p GHRHR TRIM24 FST DBI BMP2 AHR ADFP FOXA2 DCN ACR PMC6446698__F1 PI3K signaling pathway: growth factors such as insulin stimulate tyrosine kinase receptors resulting in their autophosphorylation RHEB BAD TSC1 INSR TXNIP PTEN MDM2 IRS1 PMC6842518__F5 Proposed model depicting the underlying molecular mechanism by which aqueous bark extract of T CD36 XBP1 PMC2856775__F1A Convergence of Pathways in TLR and IL-1R SignalingUpon activation, the IL-1 receptor dimerized with the IL-1 receptor accessory protein TLR1 TIRAP TLR4 TLR9 IRAK1 IRF3 TLR7 TRAF6 MYD88 PMC5355421__F1 Schematic illustration representing the microglial intracellular Ca2+signaling mediated by canonical transient receptor potential 3 (TRPC3) channels and the tripartite synapse IFNG STIM1 BDNF TRPC3 PMC7184480__F2 Schematic diagram of the RAS in the lung showing the role of ACE2 as a key element in the counter-regulatory axis of the RAS (elements in green; reviewed in Arendse et al.) TMPRSS2 ATR ADAM17 ACE2 PMC8910720__F3 Pathogenesis of Cardiac Fibrosis: A Review of Recent Progress TBR1 TNC SMAD2 SMAD6 SMAD4 RHO PMC2957678__F1 Schematic view of HMGB1 signal transduction HMGB1 PTEN MDM2 MYC PMC6323259__F4 Schematic presentation of the proposed effects of melatonin against ANIT-induced intrahepatic cholestasis KEAP1 GCLM GCLC PMC9554150__F4 Immunopathogenesis and environmental triggers in coeliac disease IFNG STAT3 TNFAIP3 IL2 MICA JAK1 PMC3573271__F1 Role of aryl hydrocarbnon receptor (AHR) signalling on CD4+ T cells STAT1 AHR FOXP3 PMC9147806__F3 Evolutionary Dance between Innate Host Antiviral Pathways and SARS-CoV-2 TBK1 STAT1 MAVS TRIM25 STAT2 IRF9 IFNAR1 IRF3 TRAF3 JAK1 TYK2 PMC8918193__F7 S100A16 promotes acute kidney injury by activating HRD1-induced ubiquitination and degradation of GSK3B and CK1A HGF S100A16 APC GSK3B CTNNB1 PMC7895420__F1 Molecular pathways control protein synthesis and degradation in skeletal myocytes IGF1 SMAD2 AMBRA1 SMAD4 MTOR PMC11877274__F1 Mechanism and site of action of pharmacological agents targeting the IL-17 signalling pathway (figure created in BioRender.com). SABR, single-arm pilot study of brodalumab IL17RC IL17RB TRAF6 IL23R PMC9019350__F1 Sea Cucumber Compounds Targeting NFKB in Cancer Treatment CCND3 LTBR CCND2 EGFR BCL2 VCAM1 MMP9 CXCR4 CXCL8 CCND1 PMC4384696__F5 Indoleamine 2,3-dioxygenase pathways of pathgenic inflammation and immune escape in cancer ELF2 MTOR PMC7830279__F1 DSB end resection and repair pathway RAD52 RAD51 PMC8572460__F1 Ferroptosis in lung cancer IREB2 TF SLC3A2 HEL60 SLC40A1 AIFM2 GPX4 LPCAT3 FACL4 HEL-S-89n SLC7A11 DHODH USP35 POR ATF3 TFRC GCLC NFE2L2 HEL110 ATF4 LCN2 HEL-S-64p HEL-75 ADA PMC8010074__F9 Craniofacial Development: Neural Crest in Molecular Embryology ALPI ALPL SOX2 COL10A1 RUNX2 COL2A1 CTNNB1 CD44 SOX6 SOST COL1A1 SOX9 DLX5 SOX5 PMC2841319__F1 Pathogenesis of kidney disease in systemic lupus erythematosus CD44 EGR1 PLG SMAD4 PMC6356271__F2 Terminal telomeric complex GCG ATR NHP2 GAR1 NOP10 CTC1 ATM STN1 TERT TEN1 POT1 TPP1 PMC7688515__F2 AMPK-mTOR axis in the co-regulation of autophagy and immunometabolism ESRRA ULK1 LGALS9 MTOR USP9X IL1B PMC5356795__F6 Identification of biomarker microRNAs for predicting the response of colorectal cancer to neoadjuvant chemoradiotherapy based on microRNA regulatory network RAD21 PCNA C2 MAL CDK2 CA14 PMC3721632__F1 Th17 cell based vaccines in mucosal immunity CXCL9 CXCL11 IFNG IF2B1 CXCL13 BCR CXCL1 CXCL10 PIGR IL23R IL1B PMC3726942__F10 Roles of the autocrine angiotensin system in ER stress-induced apoptosis of alveolar epithelial cells ATR ACE2 PMC4070007__F1 Simplified diagram of the TLR-mediated and interferon (IFN)-mediated immunity in response to viruses TLR3 TERT IRF3 IRF7 TRAF3 IRAK4 PMC4077897__F1 Emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections PIK3R4 PI3 AMBRA1 ATG14 CFTR SQSTM1 NTM HDAC6 PMC3208628__F5 Integrated Transcriptome and Binding Sites Analysis Implicates E2F in the Regulation of Self-Renewal in Human Pluripotent Stem Cells PCDH10 HELLS PRKCZ SMARCD1 CTNNB1 FGFR2 HEL-S-42 SMARCE1 FGFR4 FGFR1 HLTF NRF1 HEL2 MAPK1 FRZB GNG4 CELSR2 APC SOX2 LRP6 RAC1 SMARCD2 MAPK7 GNA11 MAP3K7 PCDH19 RRAS PMC7697203__F14 Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications CS PPY PMC3867386__F8 Pre-Symptomatic Activation of Antioxidant Responses and Alterations in Glucose and Pyruvate Metabolism in Niemann-Pick Type C1-Deficient Murine Brain ENO2 HEL-S-133P ME2 PFKP ENO1 ME1 PDK2 PFKM PMC9455248__F5 Lipidomics and Transcriptome Reveal the Effects of Feeding Systems on Fatty Acids in Yak’s Meat SCD FASN SLC27A2 ME1 PMC6553502__F2 Parallel Molecular Evolution in Pathways, Genes, and Sites in High-Elevation Hummingbirds Revealed by Comparative Transcriptomics SDHA NDUFB10 ND1 ATP6V1D COX1 ETFB UQCRB NDUFB4 NDUFS8 HEL-S-32 UQCRQ PMC5668198__F1 Neural Stem Cell-based Regenerative Approaches for the Treatment of Multiple Sclerosis TREM2 HGF IGF1 CX3CR1 TLR9 PC PMC9454092__F6 Dysregulated myokines and signaling pathways in skeletal muscle dysfunction in a cigarette smoke–induced model of chronic obstructive pulmonary disease GDF8 SMAD2 SMAD4 CS PMC9637027__F2 A3A (A) and A3B (B) expression by HPV RBX1 ZNF384 STAT2 E2F4 E2F6 UBE2L3 PMC6859461__F3 Cancer pathway analysis of DEPs MADD BAD FER MAK PMC4934079__F6 Model for how autophagy regulates Notch1 signaling pathway in biliary differentiation of hepatic progenitor cells STAT3 MTOR NOTCH1 PMC7783467__F3 FGF19 and FGF21 treatment of NASH FGF8A TG TGFBI CYP7A1 FGF21 FGFR4 PMC10706690__F6 CPNE7 study schema related to EMT CDH2 CPNE7 COL1A1 MMP2 MMP3 PMC9263642__F5 UVB irradiation differential regulate miRNAs expression in skin photoaging MAX ECSIT JUN FAS RAF1 TRADD APMAP CD14 TNF FLNA MEF2C BTK APP HP NLK PROC TRAF2 PMC9021242__F6 Hippo signaling pathway in asthma IL25 TSLP S1PR2 APC IL33 TNF CCL20 PMC3469232__F1 Cholesterol is converted to pregnenolone by cytochrome P450scc inside steroidogenic mitochondria PBR PGRMC1 SRC PMC9021242__F2 Hippo signaling pathway in ALI S1PR2 MMP2 FGF10 WNT7B PMC5345234__F5 MAP2K5-centered gene clusters exclusively based on pathway and physical interactions IL15 KIF3A CSF2 CDON TBXA2R JAK3 SETDB1 IGF1R NOX4 IL-21 POR TSC2 NUP62CL ENG FLI1 SPOP MDM2 CHRNA1 IL18RAP RET PMC9021242__F1 Hippo signaling pathway LATS1 LATS2 MYC VGLL4 PMC5345234__F4 CXCL5-centered gene network upregulated in astrocytes in response to Meth exposure CCL27 PLA2R1 CXCL5 TBXA2R CCL15 PSG1 OR2B2 POU4F1 PAX2 CPB1 IL18RAP ATP2B2 FCGR2B SAMSN1 GNB3 SCN7A PLG XCL1 HSD11B1 TACR3 CXCL10 CXCL11 AGTR2 GPR45 ZNF208 UPK1A IL1RN CEACAM8 PMC1579207__F3 Cadmium-induced regulation of SCFMet30 CD2 SKP1 CDC34 PMC9023560__F7 HGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis CDH2 NGF HGF MTOR PMC5345234__F3 Connectivity of genes that were upregulated in astrocytes by Meth SMG1 CPB2 IFNG EPOR MSR1 RBPMS PAX3 CENPF ACSL6 PTGER3 FCGR2B FCN3 SOX30 LAD1 XCL1 HSD11B1 CXCL10 ERBB3 CXCL11 NAV3 DLG2 TSHR GLRA2 IL2RG IGF1R PSG1 RAP2B ADAMTS8 PPFIBP1 HCFC1 OR2B2 POU4F1 CPB1 PHF3 GNB3 KYNU CCIN PTPN11 PTGDR PTPN22 AGTR2 GPR45 MAML1 GNRHR ZPBP KIAA0040 C2 ZNF256 EPS15L1 TRIM29 ZNF76 PMC9630901__F12 Synergic Effect of Combined Therapy of Hyperbaric Oxygen and Adipose-Derived Mesenchymal Stem Cells on Improving Locomotor Recovery After Acute Traumatic Spinal Cord Injury in Rat Mainly Through Downregulating Inflammatory and Cell-Stress Signalings GFAP MAL MTOR TRAF6 CD68 MYD88 PMC11507121__F6 Transcription and expression analysis of genes related to wax synthesis pathway in leaves of ‘Ningqi I’ goji and ‘Huangguo’ goji HEL-S-5 CER1 PMC6588834__F1 Examples of RRNPP pheromone signaling OMP SI PMC3307000__F3 JNK signaling pathway regulates axonal transport and autophagy FOXO1 BNIP3 BCL2 APP PMC6128059__F1 Representation displaying the two different signaling pathways, RET-dependent (A) and RET-independent (B).In RET-dependent, glial cell line-derived neurotrophic factor (GDNF) binds directly to GDNF family receptor alpha (GFRA)1 FYN GDNF FOS RET PMC3203674__F1 Coronin 2A-dependent LXR transrepression pathway in macrophages HDAC3 JUN TLR4 SENP3 PMC7881844__F2 Loss-of-function (LOF) mutations in components of the insulin signaling pathway found in patients with syndromes characterized by severe insulin resistance PPP1R3A INSR FOXO1 PDK2 TBC1D4 IRS1 PMC7821223__F5 Transcription-related gene network ETV5 SYK SNAI2 FOSL1 PMC4121055__F1 Beyond NPM-ALK driven lymphomagenesis: alternative drivers in Anaplastic Large Cell Lymphoma STAT3 ALK PRDM1 TP63 NODAL IRF4 NOTCH1 PMC7821223__F4 Hsf1-regulated gene network HEL-S-72p HEL-S-101 DNAJB1 BAG3 DNAJA4 HSF1 HEL-S-102 APP PMC12079090__F10 PAX7 in Breast Cancer Prognosis and Its Mechanistic Involvement in the Wnt/B‐Catenin Pathway LRP5 LRP6 CCND1 PAX7 CTNNB1 PMC4202272__F1 RANK signaling pathways SYK TMEM64 NFKB2 OSCAR NFATC1 TRAF3 TRAF6 TEC CBL BTK MAP3K7IP1 TRAF5 TRAF2 GAB2 PMC3938254__F7 Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis HEL-S-99n E2F4 CDKN2B ABCA1 PMC9181147__F4 Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review ATG3 ATG16L1 ATG12 ATG14 RB1CC1 ATG5 PMC3433920__F4 Acute phase canonical pathway and corresponding acute phase reactants identified as significant for interaction effect CRP SERPIND1 STAT3 SERPINC1 SERPING1 HEL-S-62p SERPINA3 HEL111 HRG MTOR AHSG HEL-S-92n SERPINA4 APOH C9 FGA LBP CP PMC5498655__F1 Metabolic and transport pathway for irinotecan (CPT-11) UGT1A1 CES2 CES1 APC CYP3A4 PMC9024538__F2 Targeting Wnt/Beta-Catenin Pathways in Primary Liver Tumours: From Microenvironment Signaling to Therapeutic Agents CDC42 JUN ROR2 ARHA DAAM1 PMC9224386__F4 Beneficial Effects of O-GlcNAc Stimulation in a Young Rat Model of Sepsis: Beyond Modulation of Gene Expression IDE CAD BOC CORIN EVI1 IL1A MAP2 PIAS2 CTRL ENG MALL SOS2 RELA CHUK EDAR BIK PMC11719737__F4 Molecular mechanisms of UBE2T in tumorigenesis FANCD2 APC FANCL MTOR UBE2T CTNNB1 PMC7897698__F2 Regulatory cascade of MIR211 involving the BRAF/ERK5/DUSP and PDK4 PDK4 BIRC2 PMC8822171__F3 Caffeine Therapy for Apnea of Prematurity: Role of the Circadian CLOCK Gene Polymorphism MAL AIP AHR AHRR SRC PMC7897698__F1 Model summarizing the regulation of MIR211 gene expression: MIR211 gene is nested within the TRMP1 transcript TRPM1 BCL2 KCNMA1 RAB22A PMC3466981__F2 Ubiquitin ligase complexes SCF and APC/C in ubiquitin-mediated proteolysis of regulatory molecules essential for cell cycle control CDK6 APC CDK2 CDK4 PMC3763710__F1 The p53 Pathway as a Target in Cancer Therapeutics: Obstacles and Promise BAX MDM2 PRIMA1 SIRT1 PMC3360162__F4 Synthesis of eicosanoids and their actions in mast cells LTB LTA COX1 COX2 PMC3466981__F3 The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis RAD51 BRCA1 BRCA2 ATM PMC3360162__F2 Antigen-mediated chemotaxis SYK LAT STIM1 PTEN LYN RHO GRB2 GAB2 BIK PMC6255774__F8 A simplified diagram of fatty acid synthesis, modification and assembly into triacylglycerol in developing Arabidopsis seeds LPCAT2 PC LPCAT1 PMC3376408__F1 IL-2 release by DCs stimulation of PRRs triggers the calcineurin/NFAT pathway via PLCG2 and intracellular Ca2+ flux CD40 SYK PLCG2 TLR4 TRAF6 CARD9 MYD88 PMC10136495__F3 Targeting TGFB signaling pathway in LC SOX2 COL4A1 MMP2 IL2 IL6 FOXP3 MMP9 VEGFA MYC TGFBR1 PMC10136495__F2 TGFB signaling pathway in LC development and metastasis SNAI1 SOX2 MMP2 IL6 RHO FOXP3 MMP9 MTOR VEGFA MYC TGFBR1 PMC11853202__F5 Schematic diagram displaying APOL1RRV-mediated downstream signaling pathway leading the activation of the RAS and participating in the progression of CKD NR1i1 WT1 PMC5047620__F6 Role of Dicer1-Dependent Factors in the Paracrine Regulation of Epididymal Gene Expression HDAC1 P1 DNAJB7 SHCBP1L PHOSPHO1 GGN PAPOLB PMC9616754__F1 Amyloid B in the pathological mechanism of GNE myopathy BAX GNE ULK1 APP PTEN ATF4 IGF1R XBP1 VCP PMC5486101__F1 Schematic overview of the autophagic pathway and potential drug target points of the pathway ATG101 ATG10 ATG3 ATG16L1 ATG12 ULK1 ATG5 PMC2743144__F1 mTORC1 signaling governs hematopoietic stem cell quiescence RHEB FBXW7 PML PTEN PMC5876722__F1 Oncogenic signaling networks by Kaposi’s sarcoma-associated herpesvirus SYK TSC2 EIF4B PLCG1 TSC1 EIF4E PMC5303891__F1 Development of a Reporter System for In Vivo Monitoring of Gamma-Secretase Activity in Drosophila EGF HBD PMC10521544__F6 Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma MADD HPD MATK MEA1 BAD CAD SELL COIL CYC1 PMC8419240__F5 Arsenic: Various species with different effects on cytochrome P450 regulation in humans AHR CYP1A1 PMC10521544__F4 Luteolin-target-pathway network CD40 SYK JUND PKN1 COL4A3 SLC2A4 CCL3 MCL1 IL3 HIF1A MAPK9 CCL5 MAPK8 CCL2 PLK1 CXCL8 CCNB3 MAPK3 MYD88 IFNG HMOX1 VEGFB BCL2L1 CDK6 ALK CSNK2A1 MMP2 MMP3 KDR MDM2 SRC CASP9 CSF2 FOSB VEGFA TNF CXCL10 TP63 MAP3K7 CDK2 BCL2 MAP10 TP73 TBK1 EGF CXCL12 FAS TGFB1 EGFR SFN PTEN IGF1R ACTA2 TLR4 AHR CHUK CCND1 IL1B CDK4 CDC2 VWF BAX JUN EGR1 PIM1 IL13 IL4 CD40LG IL5 FGF2 AGER NFKB1 RELA CASP3 NFKBIA ERBB2 IFNB1 TNFSF10 BIRC2 PMC8886744__F2 Apolipoprotein A1 in PPAR Signaling Pathway for Nonalcoholic Fatty Liver Disease FAS TLR4 APOE IL17A CCL2 TNF PMC8886744__F1 Apolipoprotein A1 in PPAR Signaling Pathway for Nonalcoholic Fatty Liver Disease PPARG NR1C1 NR1C2 PMC7942223__F2 One-carbon metabolism, transmethylation reactions, folate cycle, and DNA demethylation HEL-S-61p MTR TDG PMC5954032__F1 PI3K/AKT/mTOR/S6K pathway plays a major role in the control of immune cell homeostasis RHEB ICOS EIF4B CD19 PTEN CTLA4 DEPTOR PMC11558907__F2 Function and main molecular mechanism of various adipokines on myocardial ischemia/reperfusion (I/R) injury STAT3 HMGB1 CGAS METRNL CD36 ULK1 TLR4 DUSP26 IRAK2 CAP1 SIRT1 PMC12062509__F7 Cancer-related pathways in cuproptosis AARS1 SLC11A2 AARS2 LIAS HEL-S-162eP FDX1 TCF4 SLC7A11 ATP7B SLC31A1 CTNNB1 ATP7A PMC3944211__F1 Bone morphogenetic protein signaling in nephron progenitor cells JUN MAP3K7IP1 ATF2 FOS PMC12062509__F6 Cuproptosis UFD1L SLC11A2 GCSH DLAT LIAS FES FDX1 ATP7B SLC31A1 ATP7A PMC8570568__F3 An ageing innate immune system may predispose a patient to severe COVID-19 NLRP3 IL16 PDC IL6 CXCL10 CCL2 TNF ACE2 PMC12062509__F4 Copper-induced cell death BAX GPX4 MLKL ULK1 SLC7A11 MTOR XBP1 ERN1 ATP7A RIPK3 GSDMD NLRP3 TLR4 TFEB RIPK1 AIFM1 BAK1 ATG5 SLC31A1 PMC12062509__F3 Copper in promoting tumor MMP14 EGFR ULK1 APC MTOR CRIP2 PARP1 ATOX1 PDE3B LOX MMP2 ATG5 ULK2 SLC31A1 PMC7947037__F2 Betaine and choline status modify the effect of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults GAA HEL-S-182mP HEL-S-20 PEMT PC HEL-S-61p SLC19A1 MTR PMC4268103__F1 Emerging roles of Notch signaling in liver disease SOX9 NUMB ADAM10 MYC CTNNB1 PMC4412274__F2 Mechanical forces influence growth rate LATS1 PMC4693579__F2 GLP‐1 and Wnt signalling in the regulation of bone formation (A) In the inactive state of the Wnt/B‐catenin pathway, Wnt is inhibited by a decoy receptor sFRP, where as its co‐receptor LRP5/6 binds to inhibitory protein sclerostin or Dkk LPL FRAT1 SOST APC LRP5 LRP6 CTNNB1 PMC8416891__F4 Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Stimulated by Mycobacterium tuberculosis PPE57 Identifies Characteristic Genes Associated With Type I Interferon Signaling TRIM25 STAT2 NFKB1 NFKBIA MX2 IFIT2 OAS3 ISG15 TNF OAS2 PMC11062136__F1 Graphical model illustrating the complex roles of Cytokinin Response Factors (CRFs) in the trade-off between abiotic stress response and plant developmental processes PIN1 PMC8072655__F2 Nrf2 in Hearing Loss NQO1 GCLC PMC5566872__F8 Microglial responses to ischemia/reperfusion based on our in vitro and in vivo datasets STAT1 CCL16 STAT2 TLR4 IRF9 USP18 IFNAR1 MX2 OAS3 CCL5 CXCL10 PMC4233146__F1 Dendritic Cells and B cells: Unexpected Partners in Th2 development ICOS CD80 LTA LTBR CXCL13 BCR CXCR5 IL2 GATA3 PMC8742232__F3 Advances in the study of CDC42 in the female reproductive system CDC42 RAN ING3 ARHA PMC8742232__F2 Advances in the study of CDC42 in the female reproductive system PTEN MDM2 NOBOX PMC7090118__F3 Hedgehog pathway activation through the primary cilium SUFU PTCH1 SMO PMC2933688__F3 EGFR signaling and NHEJ EGF TGFA EGFR PTEN PMC9435021__F3 Biological and neurological activities of astaxanthin BAX CASP9 BAD TRADD GCLM GCLC MAF CASP3 TNF PMC4700624__F2 Changes in the representation of IGF-Akt pathway RHEB TSC2 TSC1 IGF1 RPS6KB1 IGF1R PMC12104183__F4 Signaling pathways involved in the protection of H2S against PH FAS PMC3359746__F1 Several growth factor signals activate cell membrane receptor tyrosine kinases leading to activation of downstream interacting signal transduction pathways (PI3K/AKT, RAF/MAPK, and MTOR) RHEB RPS6 TSC2 BAD TSC1 BCL2 PTEN GRB2 MTOR SHE MYC PMC3081824__F5 Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing SLC35C1 FUT1 FUT4 FUT8 FPGT FUCA1 FUT2 POFUT4 FUT5 POFUT2 GMDS POFUT3 POFUT1 FUCA2 FUT9 PMC7536854__F2 Intracellular signaling pathways govern cell growth and proliferation TF RHEB MAF1 TSC2 TSC1 SLC38A9 EIF4E PMC8275986__F1 Calcium, an Emerging Intracellular Messenger for the Hippo Pathway Regulation LATS1 LATS2 INF2 AMOTL1 PMC9180620__F6 Could a Lower Toll-like Receptor (TLR) and NFKB Activation Due to a Changed Charge Distribution in the Spike Protein Be the Reason for the Lower Pathogenicity of Omicron? TMPRSS2 TLR3 TLR4 IRF3 IRF7 TLR7 FURIN TNF ACE2 MYD88 PMC3081824__F3 Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing ST8SIA4 NANP ST6GAL2 ST6GAL1 ST8SIA1 ST6GALNAC6 ST3GAL1 NEU2 ST6GALNAC2 ST6GALNAC1 ST3GAL5 ST3GAL3 ST3GAL6 NEU3 ST8SIA5 NEU1 ST8SIA6 CMAS ST8SIA2 SLC17A5 NANS SLC35A1 SIAT4C NEU4 GNE PMC6985874__F1 SCF is highly expressed in IPF lungs and blood STAT3 CSA2 PIM1 FRK NFKBIA KLF1 RPL7 ITGAV MEF2C PS1TP5BP1 PMC7176996__F5 Involvement of angelicin in several apoptotic pathways which promote cancer cell death EGFR MTOR APAF1 FADD PMC8966512__F1 Intestinal Wnt in the transition from physiology to oncology BCL9 DKK1 APC LRP5 LRP6 PMC3404158__F2A Ubiquitination and Phosphorylation in the Regulation of NOD2 signaling and NOD2-mediated Disease TAB3 NOD2 PMC5293764__F1 Carbohydrate metabolism in I HEL107 ACAD9 FH HEL-S-68p HEL-S-162eP PMC6939200__EV5 Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor STXBP4 AMOT CTNNB1 PMC2397440__F8 Possible role of AICAR and compound C on the AMPK pathway and on glycolysis in CT-2A and astrocytes under low glucose conditions TSC2 COMP MTOR PMC7351732__F3 MYC regulation of essential amino acid and lipid metabolism ACLY HMGCR KYNU FASN KMO SLC7A5 AFMID CIT PMC7351732__F4 MYC coordinates multiple metabolic events to activate nucleotide metabolism HEL107 CAD SMS IMPDH1 ARG1 IMPDH2 DHODH OMP PHGDH SRM PSAT1 MTR PSPH PMC8945563__F2 Immunotherapy for SMARCB1-Deficient Sarcomas: Current Evidence and Future Developments TBK1 CGAS MAVS PMC7846573__F7 FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability FANCD2 UBL5 ATF4 PMC3940969__F2 TLR signaling pathways in cerebral IT TLR1 LTA TIRAP TLR4 TLR9 IRAK1 IRF3 IRF7 TLR7 TRAF6 IRAK4 MYD88 PMC12089955__F5 Proposed mechanisms of action for L. sakei LB-P12 in OA TNF PMC7753186__F2 Mechanisms involved in SARS-CoV-2 infection delineating an ACE/ACE2-ATR1-Cholesterol-HDAC axis IL6 ACE2 PMC9318366__F6 Inosine Pretreatment Attenuates LPS-Induced Lung Injury through Regulating the TLR4/MyD88/NFKB Signaling Pathway In Vivo GCA MPO PMC3532163__F4 Characterization of the Phosphoproteome in SLE Patients MAX ECSIT EGF JUN FAS EGFR CD14 TNF NGF MOS NLK BDNF TRAF2 PMC9085228__F3 miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer TH ALK MAK WAS MTOR FAM83D PMC5610219__F2 Multiple miRNA biogenesis pathways AGO4 NTS AGO1 XPO5 AGO2 PHAX DROSHA PMC3748257__F2 STAT signaling in mammary gland differentiation, cell survival and tumorigenesis STAT1 MUC1 PMC4057083__F8 On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio CXCR3 CHRM2 PLXNA3 NGFR JAK3 FGFR1 CCR7 FGFR3 GRB2 CXCR4 FGFR2 PMC9142129__F6 Inference of Molecular Regulatory Systems Using Statistical Path-Consistency Algorithm MAX ECSIT JUND FAS RAF1 CD14 TRAF6 MAP3K7IP1 NF1 PAK1 GCK GRB2 TRAF2 PMC8067389__F3 HCMV dysregulates the Notch signaling pathway STAT3 SOX2 JAG2 HES1 NOTCH1 HES5 PMC8067389__F2 HCMV regulates the canonical Wnt/Beta-catenin signaling pathway APC CTNNB1 PMC3131147__F2 Possible pathways to androgen independence and the involvement of ANG MTOR EIF4E PMC7330701__F4 Schematic that illustrates the hypothesis of how the interferon tau (IFN-τ) acts on positive HPV 16 tumor cells STAT3 STAT1 RAF1 STAT2 IFNAR2 IFNAR1 STAT4 JAK1 RAC1 TYK2 PMC5372499__F3 USP15 acts as a “biological thermostat” in the TGFB signaling pathway USP15 SMURF2 PMC10886030__F4 Oxidative inactivation of PTEN in insulin-related metabolism and muscle differentiation EGF PTEN MTOR PMC5385041__F4 Diagram of glycolysis is shown, including enzymes whose transcripts were more highly expressed in GRMD (red) or wild type dogs (green) HEL107 GOT2 PYGB MPC1 MPC2 SLC17A5 SLC25A12 SLC25A11 FBP2 HEL-S-68p F2 PGM2 FBP1 LDHD ENO1 HEL-S-26 PMC6356247__F2 Effects of chemotherapy on coagulation activation TF APC PC PMC8108341__F9 Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9 TIMELESS CCND1 LEF1 CTNNB1 PMC6533072__F3 Estrogen biosynthesis pathway HSD3B2 CYP17A1 CYP11A1 HSD17B1 PMC5770148__F1 Tibim1 reduces TLR4-dependent liver damage TUB TLR4 TMBIM1 PMC8620763__F1 Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study UGT1A3 ACSM2B HEL-S-5 CYP2C9 BCHE HEL-S-303 PMC7482583__F1 LRRK2’s potential involvement in pre- and post-synaptic pathways VPS35 LRRK2 SNAPIN PMC2518463__F2 Binding of specific signalling proteins to phosphorylated tyrosine residues on KIT following receptor activation and the subsequent signalling events leading to mast cell responses STAT3 CRK STAT1 BTK FYN KIT LYN GRB2 PMC6063270__F6 Repeated Cis-Regulatory Tuning of a Metabolic Bottleneck Gene during Evolution GAL PGM2 PMC4104311__F2 Small System—High-Resolution Study of Metabolic Adaptation in the Central Metabolic Pathway to Temperate Climates in Drosophila melanogaster SDHD GOT2 HEL-S-304 HEXA PC TREH HEL-S-32 MDH2 PMC6063270__F1 Repeated Cis-Regulatory Tuning of a Metabolic Bottleneck Gene during Evolution GAL PGM2 PMC8235519__F8 Comparative Analysis of Flavonoid Metabolites in Foxtail Millet (Setaria italica) with Different Eating Quality NMB AMH MMD PMC8473084__F5 Recombinant Antigen of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2) Promotes M1 Repolarization of Porcine Alveolar Macrophages and Th1 Type Response POR MAVS UBE2L6 MAK USP18 MX2 BCL2 MX1 ISG15 CYLD PMC8473084__F4 Recombinant Antigen of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2) Promotes M1 Repolarization of Porcine Alveolar Macrophages and Th1 Type Response EED AEBP2 LAT EZH2 OTP PMC6541219__F1 Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement TF TRPS1 PDE4D PTH PMC2939609__F3 Molecular interactomes and sub-networks associated with tumor cell susceptibility to arsenic trioxide KLF4 ARID1A PPARG HMGN2 NASP FLNB LAMC2 VAV2 IFI16 SDC1 HTATIP2 ID1 IRF6 GRB7 CTBP2 PLEKHO1 E2F3 NOL3 LPAR2 ARID2 AMFR TPD52L1 MSX2 PMC9267007__F1 Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair STAT3 BAX BCR EPOR EPO CTNNB1 PMC4028332__F2 After the banquet MAPK1 TFAM LONP1 PINK1 ZNF746 PRKAA2 HEL159 PPARGC1A YY1 MYC SIRT1 PMC5050441__F33 Multitargeted modulation of estrogen carcinogenesis by botanicals KEAP1 MAL AHR PMC7595250__F2 Cellular signaling pathways involved in cell senescence in renal ageing CDK6 GSK3B CDK2 WNT9A SIRT1 CDK4 PMC8860249__F2 Emerging Roles of Pellino Family in Pattern Recognition Receptor Signaling DKFZp781O1323 TLR4 IRAK1 TRAF3 TRAF6 REL IRAK4 MYD88 PMC9179306__F5 Identification of the Key Genes Associated with Different Hair Types in the Inner Mongolia Cashmere Goat GPRC5D ASL PPIF FGF21 ZRANB1 HMOX1 PPP1R15A TGM3 DUSP14 OTUB2 FGF22 KRT39 IVL PRR9 MALL LAP3 TCHH TGM7 KRT9 KRTAP3-1 KRTAP11-1 FABP9 KRT74 KRT27 CRNN PMC6587965__F1 Cellular Signaling Pathways Modulated by Low-intensity Extracorporeal Shock Wave Therapy TSC2 MTOR SRC BDNF PMC9326486__F1 Therapeutic Potential of Targeting NIK in B Cell Malignancies RELB TRAF3 TRAF2 PMC6299370__F1 The activation of Wnt/Beta-catenin signaling by different oncogenic lncRNAs in liver cancer CTCF CTNNBIP1 APC GSK3B CTNNB1 PMC4517123__F2 Innate immune sensing of rhabdovirus infection TBK1 TANK IRF3 IRF7 TRAF3 FADD PMC9097822__F1 Signalling dynamics, cell decisions, and homeostatic control in health and disease EGF TGFA NRG3 AREG FOS NRG4 NRG2 NRG1 HBEGF EREG EPGN BTC CCND1 PMC4999628__F5 A model for a role for AIISp in the repair of DNA ICLs ERCC1 FANCD2 FANCG PMC6485480__F1 Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers EXTL1 HS3ST1 GCNT4 UGCG FUT4 FUT6 C1GALT1 FUT3 FUT5 FUT7 HS2ST1 ST3GAL1 NDST3 B3GAT1 ST6GALNAC2 FUT9 GCNT2 ST6GALNAC1 GCNT3 B4GALT5 ST3GAL3 B4GALT1 ST3GAL6 EXT1 CHST4 B3GALT6 B3GNT5 HS6ST1 HEL-S-75 XYLT1 EXT2 GCNT1 PMC4213475__F2 Model of the JAK-STAT pathway in CRC with the corresponding significant changes in the signaling circuit activities CBLC SOCS4 CISH MYC STATH PMC4213475__F4 Signaling changes in the T-Cell receptor signaling pathway of human bone marrow hematopoietic stem cells LCP2 LAT PTPRC CD40LG ARHA FOS ICOS CRB2 FYN CBLC IKBKB ITK GRB2 LCK PMC2716793__F3 Spatial complexity and control of a bacterial cell cycle PERP PLEC POLE PMC10311615__F11 18Beta-glycyrrhetinic acid inhibits proliferation of gastric cancer cells through regulating the miR-345-5p/TGM2 signaling pathway NBR1 SQSTM1 MTOR PMC9018123__F4 Putative functions of EpsK in teichuronic acid synthesis and phosphate starvation in Bacillus licheniformis JUP COMP CAP1 PMC8000623__F2 Summary of survival tactics of MAH within phagocytes from host innate immune effectors MAH infection JUN ARCN1 STX8 CTSZ AP3B1 PMC12205806__F1 Part 1: The process of HBV infection and replication in cells: (A) HBV enters the liver cell via fusion and endocytosis LPP CTNNB1 PMC5026573__F6 JNK pathway activation modulates acquired resistance to EGFR/HER2 targeted therapies EGFR IGF1R UNK PMC6637517__F6 Model depicting cascade of the anti-inflammatory effect of ciprofloxacin and levofloxacin, targeting TLR4–MD-2 complex TLR4 CD14 LBP IL1B PMC2949900__F4 Cell Cycle Pathway: Differentially expressed genes involved in the cell cycle are shown in pink CDC2 RAD21 MALL PCNA PI3 SMAD2 SMAD4 CDK2 SAE1 SKP2 PMC6425072__F2 Neurotrophic factors and their receptors in dopamine neurons CNTFR CNTF GDNF NRTN GDF15 LIF GFRAL BDNF CDNF RET PMC6716105__F7 Mechanism of the NFKB Signaling Pathway Mediated by LINC01093Overexpression of LINC01093 can target ICAM-1 negatively and then inhibit apoptosis and enhance proliferation by suppressing the NFKB signaling pathway, thereby attenuating AH BAX CASP3 PMC10755684__F2 Neuroinflammation in the transition of acute to chronic pain and the opioid-induced hyperalgesia and tolerance NTS CSF1 CSF3 PMC10853261__F8 Proposed model of GC-induced adiposity STAT3 KIF9 SIN3A KLF9 UCP1 ARG1 PTGS2 PMC2929731__F8 cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways AQP4 VIP AQP3 NAV2 CFTR AQP5 PMC3733265__F1 Mimicking the BH3 domain to kill cancer cells BAX BAD BMF PMC3072784__F8 A kinase cascade regulating pIgR transcytosis PIGA RAB11A EGFR PIGR PMC4530307__F1 “aggressive pathway.” Up-regulated genes (red) and downregulated genes (blue) are interconnected in a pathway involved in cell cycle control DBF4 THBS1 HMMR TSG101 CENPE HTATIP2 MYC CD44 CDKN2A PTTG1 CDCA5 CENPK AURKB DGKZ CCNB1 PMC7927668__F5 KEGG mTOR signaling pathway map comparing +AMR/+DSA and +DSA vs TH MOS PTEN RNF152 MIOS PMC5345234__F9 IL2RG-centered gene subnetwork DLG2 TRIM14 DHRS7 ZMIZ2 IL2RG PTPN11 VAV1 IGF1R CSF3R IL-21 SPN ERBB3 PTPN22 MED12 REN BRS3 PARP11 EPOR HCFC1 PRELP TAP2 RGS1 PMC8451771__F3 Apoptosis – Fueling the oncogenic fire CDC42 STAT3 CGAS RAC1 PMC8466405__F4 Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome TIRAP IL6 MYD88 PMC2612938__F2 Pathways by which Mgrn1-mediated ubiquitination could modulate melanocortin receptor regulation of pigment production and energy metabolism MC1R MGRN1 MC4R MC3R ATM AgRP PMC8468592__F2 Glucocorticoid and PD-1 Cross-Talk: Does the Immune System Become Confused? APC CDK2 PTEN GATA3 PMC5589626__F7 Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRA/AKT cascade restrains tuberous sclerosis complex-associated tumor development MLST8 TSC2 TSC1 PDGFRA PTEN MTOR DEPTOR IRS1 PMC5995077__F7 DMix regulates hepatic gluconeogenesis in diabetic rats via the PI3K/Akt signaling pathway INSR FOXO1 INS PMC7775273__F5 Mechanical Regulation of Apoptosis in the Cardiovascular System CASP9 CASP8 TRADD CASP3 CASP10 FADD PMC4825184__F1 TLR and NLR pathways driving pro-inflammatory state after exposure to extracellular and Intracellular microbial products IL19 TLR5 NOD1 MYD88 PMC4641903__F2 Summary of the roles of alpha-synuclein and other PD-associated proteins in the secretory pathway and the resulting stress responses BAG5 RAB1A PINK1 CDK5 RAB11A LRRK2 ARF4 RAB1B XBP1 PMC3654375__F3 Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning SHB ARHA RAC1 PMC8411019__F2 Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders GPR32 GPR37 FPR2 RORA LGR6 PMC3983859__F6 Schematic representation of the RvD1 contribution to microglia alternative activation ARG1 FPR2 PMC5510550__F1 Negative Regulation of Type 2 Immunity IL25 TSLP IL33 PMC4280507__F4 One carbon metabolism and the effects of alcohol (EtOH) and nutrition throughout the metabolical pathway HEL-S-182mP DHFR MTR HEL-S-64p CP PMC3674144__F1 New look at TCR signaling to NFKB BCL10 RELB MIB2 TRAF6 CYLD TRAF2 HOMER3 PMC6478801__F8 SNG mediated action in MM cells STAT3 BAX HEL-S-62p C9 BCL2 PMC7280204__F8 Signaling pathways involved in osteocyte mechanobiology FRAT1 PTGER2 SOST SMAD2 CTSK PTGER4 RHO SRC PMC4358122__F5 Reciprocal regulation of AMPK and PLD RHEB TSC2 TSC1 PMC4367691__F1 ROR1 signaling pathway ERBB3 ROR1 STAT3 EGF NRG1 EGFR BRAF PTEN JAK1 PMC6329812__F2 The stress adaptive processes induced by mutant p53 trigger positive loops feeding its own accumulation in cancer cells HSF1 ARHA MDM2 HDAC6 PMC4931093__F1 Mechanotransduction in transcriptional regulation AMOT MAL ARHA CTNNB1 PMC4237867__F1 Signaling pathway of toll-like receptors (TLRs) TBK1 TLR1 TIRAP TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 TLR7 TRAF6 MYD88 PMC2895650__F1 Multi-Variant Pathway Association Analysis Reveals the Importance of Genetic Determinants of Estrogen Metabolism in Breast and Endometrial Cancer Susceptibility NAT2 HEL-S-22 UGT2B4 HSD11B1 STS NAT1 PMC6080105__F1 Short and Long Noncoding RNAs Regulate the Epigenetic Status of Cells AGO1 POLR3D CSDC2 EZH2 NOTCH3 PMC3943799__F2 Cytosolic DNA sensing pathways MAVS DHX36 DDX41 AIM2 IFI16 IRF3 IRF7 CTNNB1 MYD88 PMC3819657__F3 Combined miRNA/mRNA regulatory and functional enrichment network EREG COL8A1 RUNX1 PIM1 ARRB2 PIK3CD CMPK2 SOCS3 PMC4880707__F1 Suggested positive feedback loop in SOD3 signal transduction FYN BRAF LYN VEGFA SRC PMC5580463__F4 PI3K/AKT and RAS/EGFR/ERK pathways ERBB3 BAD TSC1 EGFR ERBB2 PTEN MDM2 GRB2 MTOR PMC5338029__F5 Syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFB and Activin pathways TSHB TRH TGFB1 IGSF1 SMAD2 SMAD4 FSHR TRHR FSHB PMC5622428__F4 Network based on a restricted number of genes after selection of topological parameters FAS CASP2 BCL2 VEGFA OSTC PMC8297972__F1 Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease COX1 IL33 FPR2 PMC4445728__F1 Development and in vivo function of TH9 cells IFNG TH STAT3 APC STAT4 PMC6710335__F8 The working model of Tpl2 in protecting against fulminant hepatitis IL25 CXCL1 CXCL2 PMC6595474__F8 Summary of mechanisms by which exosomes from cyclic stretch-exposed PDL cells negatively regulate IL-1B production in macrophages NLRP3 TLR4 IL1B PMC5711888__F3 A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis BMP10 STAT3 VEGFC KLF2 SMAD1 TGFB1 SMAD2 NRP1 SMAD6 NRARP VEGFD VEGFA CTNNB1 WNT7A SRC PMC5711888__F2 A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis CDC42 BMP10 VEGFC KLF2 TGFBI CLK4 SMAD4 PTEN RYK MTOR TRAF6 FGFR2 FYN ADAM17 NF1 WNT1 SRC CCND1 NOTCH1 PIEZO1 AXL APC SMAD6 NRARP VEGFD VEGFA AXIN2 SFRP1 TSC2 ENG PIGF TSC1 SPRED1 AXIN1 ADAM10 DAAM1 PMC6343099__F2 Regulated signal pathways and transcription factors of NCX1 in digestive diseases TRPC1 SMAD4 TRPC6 PMC8967572__F4 Dietary Phytochemicals Targeting Nrf2 to Enhance the Radiosensitivity of Cancer ATR CGN KEAP1 ATM PMC8602556__F1 Crosstalk Between ER Stress, Autophagy and Inflammation ATF6B TBK1 ATF5 NLRP3 TXNIP IRF3 ATF4 EIF2A TRAF2 IL1B PMC2394752__F4 Contextual organization of the NFKB positive modulators CD40 ST13 RAN LTA TRAPPC1 MASTL TIRAP PAAT TNFRSF10B VPS52 PLK2 HSBP1 TNFRSF25 B3GALT4 NET1 KLHL12 OPHN1 ACADVL TM7SF2 PHYH TNFRSF11A TNFRSF12A SLC19A2 SLC7A10 DUT TNF GPD1 TROAP SLC22A7 ZNF443 SNX16 MAP3K7 EGR2 CYBB ADAR PLEK2 TNFRSF1B CCL22 PYCARD TNFRSF1A PAK4 CCNL2 GPR108 ATP2A2 PLEKHB1 MAP3K14 TNFRSF10A GDA IKBKG SSBP2 TYRO3 MLX KCNIP4 RBM6 NUTF2 GNA15 CAMK2D IKBKB RRAS GJB6 TNFSF10 BIRC2 TRAF2 FADD MBD2 PMC12027414__F6 Impact of NPC86 on insulin signaling and inflammatory pathways in adipose tissue PHKA1 BAD SOS1 GYS2 PIK3R3 GSK3B PTPRF ACACA SOCS3 MTOR INS SH2B2 HEL-S-42 SOST INSR AK2 RPTOR PYGM EXOC7 EIF4EBP1 HK2 FASN TRIP10 INPP1 ARAF HRAS RHEB INPP5A G6PC3 CRK TSC2 PDE3B CBL PRKCI TSC1 FBP2 FOXO1 GYS1 LIPE PRKAB1 MAPK10 INPPL1 MAP2K1 GRB2 PMC6139039__F1 Stabilizing and destabilizing signals for Tregs IFNG NRP1 PTEN CTLA4 FOXP3 PMC8784108__F4 Insight into the symbiotic lifestyle of DPANN archaea revealed by cultivation and genome analyses FEN1 TBP POLD2 PMC10548218__F1 FGF effects in breast cancer cells FGF7 FRS2 FGF9 GRB2 FGF10 FGF2 PMC4523312__F2 Protein interaction pathway produced by combining known protein–protein interactions from the literature CDC42 STAT3 BAX BAD MCL1 PTEN ATF2 MTOR RHO FOS IRS1 BCL2 CCND1 PMC7306315__F1 Iron homeostasis and signaling pathways involved in hepcidin regulation ERFE EPO HAMP HFE2 PMC5512429__F3 Cellular signaling pathways and transcriptional regulatory circuits mediating physiologic cardiac hypertrophic growth CITED4 IGF1 PI3 NRF1 IRS1 PMC9032101__F1 Importance of Endoplasmic Reticulum Stress as a Novel Antidepressant Drug Target and Its Potential Impact on CNS Disorders EDEM1 ELF2 ATF4 BDNF PMC3479160__F5 PPI subnetworks of the extended disease pathways FZD5 EGF FGF13 BAD FGF12 HGF FGF7B CYCS GSK3B PTEN APC2 PSENEN MUTYH PDGFC A2M FZD1 CCND1 IL1B LPL IDE BAX JUN MSH2 MSH3 E2F2 FZD2 PDGFA APOE HSD17B10 FZD9 HRG SNCA NAE1 BACE2 KRAS NEDD8 TCF7L2 FZD4 IGF1 FER HEL-S-162eP PSEN2 PMC8977417__F2 Biological Characteristics and Clinical Significance of Soluble PD-1/PD-L1 and Exosomal PD-L1 in Cancer HEL-S-92n CD80 SPDL1 MTOR PMC7954751__F9 Hormonal regulation of human DNA methyl transferases DNMT3B GC F3 PTH SRC PMC6745489__F5 Rectal cancer sub-clones respond differentially to neoadjuvant therapy MAX SPTB PRMT2 P4HA2 PTEN TRPC5 SETDB1 C1QBP UPF3A PIGT HIPK2 BCR tmp_locus_29 MYPN TTN SRPK2 CPSF1 HTT LPL ALYREF GPAA1 MNT APC SYNE1 POLE4 CCL28 EIF3E MAD2L2 POLK SRSF6 TRPC3 RNPS1 PMC6128733__F1 Neurotrophin Trafficking via Trk Receptors NGF SNAPIN RAC1 MEF2D PMC3902842__F3 Molecular mechanisms involved in leptin receptor signaling in the hypothalamus STAT3 PMC8261751__F2 Coronavirus disease and the cardiovascular system: a narrative review of the mechanisms of injury and management implications ACE2 PMC3234335__F1 Hereditary Hemochromatosis and Transferrin Receptor 2 TF STAT3 BMP6 SMAD1 TFR2 DKFZp781O1323 SMAD4 HAMP HFE IL6 IL6R PMC12071082__F3 Therapies targeting RASGAPs in urological cancers DAB2IP ATM EZH2 PMC6128733__F2 Neurotrophin Trafficking via Trk Receptors NGF RAB27B SNX26 KIF1A PMC11007187__F4 Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies RHEB TSC2 TSC1 PTEN GRB2 MTOR BDNF SIRT1 PMC11007187__F1 Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies AGO4 RAN AGO1 AGO2 DROSHA PMC8615487__F2 An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes STAT3 TET2 BRD4 TXNIP MARK4 SIRT2 XBP1 MYD88 UCP2 SIRT3 NLRP3 IL16 RELA ELF3 PMC4033011__F2 Possible pathways for LRP1-mediated AB uptake ARHA RAC1 PMC4650429__F1 During normal cellular conditions, BRD4 recognizes acetylated lysine residues on histones and recruits positive transcription elongation factor b (P-TEFb) to promote transcriptional elongation by RNA polymerase II of key oncogenic drivers such as MYC BRD4 MYC CTNNB1 PMC7609776__F4 KEGG AD pathway including Cd-associated transcripts in males LPL IDE CASP9 BAD CASP12 APOE CASP3 SNCA APP TNF APAF1 FADD PMC11860889__F1 Activation or silencing of WNT signaling pathway in the presence or absence of WNT ligands 1 APC LRP5 LRP6 TWIST1 CTNNB1 PMC7783665__F1 Calcineurin-NFAT pathway for expression of cytokines and cell membrane proteins CD40 PLCG2 IL2 PMC6412382__F1 Mammalian target of rapamycin (mTOR) regulatory network PIK3CA TNFRSF1A ULK1 TTI1 PTEN FLCN MTOR SLC7A5 INS GRB10 RHOD CHUK TBC1D7 APP AKT1S1 FNIP1 RRAGA RPS6 EIF4B RRAGB RRAGD SGK1 EIF4EBP1 CASTOR1 DEPTOR IRS1 EIF4E RHEB MLST8 TSC2 RICTOR TSC1 RPS6KB1 PRKAA2 IKBKB LPIN1 PRRT2 ETV7 GRB2 SLC38A9 PMC7783665__F4 Calcineurin activation by cAMP/PKA and interaction with CaM for cell secretion VWF S100A10 ANXA2 CFTR PMC3562392__F3 Cytoscape diagram of the functional interaction network representing proteins modulation in Pt1 interstitial fluid SPTB ARHGAP4 HEL-S-101 HEL113 AMBP SERPINA1 HEL-S-78p SPTA1 ALB MYO1C SP4 LSM7 EIF3M APOB FGA PMC4997298__F6 Upstream regulatory analysis of weight-loss–associated genes identified strong C/EBPA activation ACLY HEL114 CEBPA LEP TUBB2A EPHX1 SCD SERPINI1 NRP1 ACACA PPL PMC4200329__F4 Schematic representation of the amniotic fluid eicosanoid profile LTB PMC12012437__F1 S100P signaling pathways associated with proliferation, apoptosis, migration, invasion and EMT in tumors STAT1 BCL10 SOX9 KEAP1 TXNIP SIX3 SMAD4 ATF4 S100P CTNNB1 PMC10740567__F1 Signaling pathways involved in the inhibition of apoptosis by Apicomplexan protozoa STAT3 BAX TRADD EGFR TNF APAF1 TRAF2 FADD PMC12012437__F2 S100P signaling pathways associated with angiogenesis, cell cycle and drug resistance in tumors TFF1 LPXN S100P PMC5531310__F3 Glycolysis is downregulated in idiopathic pulmonary fibrosis (IPF) lungs, with possible shuttling of intermediates to the sorbitol and pentose phosphate pathways G6PC3 PGAM1 SLC2A4RG PMC5531310__F2 Arginine metabolism is increased in the idiopathic pulmonary fibrosis (IPF) lung ARG1 ARG2 PMC5531310__F1 Downregulated sphingolipid metabolism in idiopathic pulmonary fibrosis (IPF) lungs S1PR1 SMPD4 SPHK1 DEGS1 SMPD1 ACER3 S1PR4 PMC8537973__F10 Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations NFKB2 PIK3R2 JAK3 HEL-S-269 PRKAG2 NDUFA10 MMP11 VEGFB PIK3C2B MED14 PDGFC MMP2 ATF4 TBL1XR1 NRF1 MED13 CCND1 HES1 JUN MYL6 GNB3 SP1 DLG4 ARHA FOS HRAS RAP2A ENG IGF1 SDHC SETD7 PMC2268699__F2 FGF canonical signalling pathway STAT3 CRK MAPKAPK2 PMC2268699__F1 p38 MAPK canonical signalling pathway MAX STAT1 FAS MAP3K7IP1 TRADD MAPKAPK2 MAPKAPK3 ATF2 TRAF6 TRAF2 FADD PMC7112453__F1 NAD+ metabolism pathways in mammals NRK NAPRT HEL-S-90n NADK NAMPT NMNAT2 NMNAT3 PMC8939237__F1 Regulatory Pathways Governing Metabolic Control of Puberty Discerned from Rodent, Nonhuman Primate, and Human Studies EED SHBG ARC MTOR SIRT1 PMC3783495__F7 Antagonism of Betulinic Acid on LPS-Mediated Inhibition of ABCA1 and Cholesterol Efflux through Inhibiting Nuclear Factor-kappaB Signaling Pathway and miR-33 Expression TLR4 ABCA1 MYD88 PMC3901678__F6 Mining Gene Expression Data for Pollutants (Dioxin, Toluene, Formaldehyde) and Low Dose of Gamma-Irradiation SYP WAS DCT PMC10478265__F2 The cGAS-STING pathway in radiotherapy for non-small cell lung cancer CXCL9 CGAS IRF3 CXCL10 PMC10478265__F1 The cGAS-STING pathway in radiotherapy for non-small cell lung cancer CGAS IRF3 TNF PMC5915650__F7 Proposed mechanotransduction mechanism BMP2 RHO RUNX2 CTNNB1 PMC6562751__F2 Signaling Pathways and Cellular Processes Regulated by Keratins, Vimentin, and Nestin STAT3 CXCR3 TRADD SP1 AXL EGFR SMAD2 GSK3B AIRE MTOR RAC1 CTNNB1 HRAS TSC2 TSC1 CDK5 NLRP3 FGFR1 SP3 SRC HNRNPK PMC5768180__F7 Interferon regulatory factor 5 regulates B cell proliferation and cell cycle ATR CDC20 PCNA E2F2 APC SKP2 RBL1 MPP2 PRKDC CDK2 ATM HDAC7 MCM2 HEL2 YWHAZ YWHAG PMC8235370__F1 Coronavirus RNA-Processing Enzymes in Innate Immune Evasion STAT1 STAT2 IRF9 PMC3714203__F2 DR4 and DR5 Agonistic mAb-induced Apoptosis: Regulation of TRAIL/Apo2L Resistance by HDACi BAD BIK DIABLO PMC8705212__F4 Camptothecin Encapsulated in Beta-Cyclodextrin-EDTA-Fe3O4 Nanoparticles Induce Metabolic Reprogramming Repair in HT29 Cancer Cells through Epigenetic Modulation: A Bioinformatics Approach ACLY HEL107 PAICS FH TIGAR PYCR2 PMC8918554__F9 The functions of NR2F1-AS1 in pancreatic cancer MTOR NR2F1 PMC10540332__F7 Combined transcriptomic and metabolomic analysis of alginate oligosaccharides alleviating salt stress in rice seedlings LAP3 PMC3627976__F1 The polyamine pathway AMD1 SMS SRM PMC4892997__F1 Antiviral Innate Immunity through the lens of Systems Biology TBK1 CGAS IFNLR1 MAVS STAT2 IRF9 IFIT1 RNASEL IFIT2 IRF3 IFI16 IRF7 RAC1 RIGI DHX36 IFNAR2 TLR4 USP18 IFNAR1 NOD2 TYK2 PMC8297769__F7 Summary and model of synergistic myocardial infarct size reduction by IPC in cardiac-specific SOCS3-deficient mice STAT3 EPO SOCS3 PMC12092085__F4 Biodegradable magnesium-based implants inhibit osteoclast differentiation through multiple mechanisms TRAF5 NFATC1 TRAF6 TRAF2 PMC3619548__F1 Schematic summary of the most common mutations found in melanoma patients CDKN2A BRAF PTEN PMC6425966__F3 Examples of prediction by eQTL signal convergence across distinct chromosomes CD40 FCGR2C KCNK7 PMC12092085__F8 PTH reduces the binding of RANKL to OPG by inhibiting the secretion of OPG from osteoblasts and acting on the cAMP-PKA-CREB and PP1/PP2A-CRTC3 pathways JUN CRTC3 SIK3 SIK2 PTH PMC12092085__F1 Magnesium promotes osteogenesis TRPM7 SP7 MSC PMC8394846__F1 NFKB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models LTB RELB REL CYLD PMC3410583__F3 Pathways of autophagy induction by hypoxia and mutant RAS BNIP3 HIF1A ATF4 BNIP3L MTOR ATG5 PMC3460904__F7 Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours SMURF1 INHBA ID2 FST SMAD2 SMAD6 SMAD4 NODAL SMURF2 ID1 ID3 PMC3509664__F3 PKR and the Insulin signaling pathway TSC2 MTOR IRS1 EIF4E PMC5382109__F6 Therapeutic targets in B cell lymphoma of NFKB activation CSA2 CD79B SYK BTK BCR LYN FOS MYD88 PMC3928598__F1 Protein O-linked ß-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function OGA OGT PMC4589285__F11 Hemorrhage Exacerbates Radiation Effects on Survival, Leukocytopenia, Thrombopenia, Erythropenia, Bone Marrow Cell Depletion and Hematopoiesis, and Inflammation-Associated microRNAs Expression in Kidney HEL-S-31 HRAS BMPR2 JUN TLR4 EGFR FADD TGFBR1 PMC3509664__F8 PKR, ISG15 as modulators of IFN induction during HCV infection MAVS TRIM25 IRF3 TRAF3 ISG15 EIF2A PMC5382109__F3 Apoptotic pathways of NFKB: TRAIL mediating the extrinsic pathway and p53 mediating the intrinsic pathway BAX RELA APAF1 PMC3509664__F7 HCV and induction of the innate immune response MAVS TRIM25 TLR3 IRF3 PMC5382109__F2 Activation modes of NFKB in the pathogenesis of B cell lymphoma SYK CD79A BCL10 CARD11 BLNK CD19 PTEN LYN PMC5382109__F5 Extrinsic and intrinsic signaling of BCR signaling activates NFKB in B-cell malignancies BCL10 BCR CARD11 RELB MYD88 PMC5530905__F1 Action of PPARG ligands and p38 MAPK on transforming growth factor (TGF)B1–induced Beta-catenin signaling in corneal fibroblasts APC GSK3B PMC5901476__F1 Mineral and bone disorders in chronic kidney disease (CKD) DKK1 PTH FGF23 PMC3460238__F1B Central role of AP convertase in complement activation CD59 HEL-S-62p MBP CD46 CD55 CP PMC5382109__F1 Canonical and non-canonical NFKB pathways CD79B SYK BTK BCL10 RELA RELB TRAF6 REL PMC3686839__F2 Molecular Pathways: Extracting Medical Knowledge from High Throughput Genomic Data MAPK14 PIK3CA JUN MAP2K4 MAP3K1 NFKBIA PIK3R1 CD19 PTEN MAPK8 MYC PMC5901476__F3 Proposed mechanisms by which PTH activates Wnt/Beta-catenin pathway in osteoblasts and osteocytes to modulate bone turnover GSK3B PTH CTNNB1 PMC7176583__F1 Gastric cancer: genome damaged by bugs STAT3 EGR1 COX2 APC GSK3B SMOX NOD1 SRC TRAF6 IL1B CTNNB1 PMC3038050__F1 Mechanisms by which CD44 can modulate cell death CD44 FAS ECD MTOR FADD PMC5320748__F1 Similar signaling cascades involved with neuroprotection for insulin-like peptides and sex hormones BAD IGF1 IGF1R MTOR IRS1 PMC10967781__F2 Insulin-like Growth Factor-1 Receptor in Tobacco Smoking-Associated Lung Cancer Development BAD IGF1 IGFBP5 IGFBP1 BCL2 IGFBP2 IGF1R MTOR IGF2 IGFBP6 PMC10967781__F1 Functional connections between the IR and IGF-R signaling axis IGF2R IGF1 IGF1R IGF2 PMC8626172__F8 Network Pharmacology‐Based Study on the Active Component and Mechanism of the Anti-Gastric-Cancer Effect of Herba Sarcandrae PTGER3 SELE CXCL2 PTGS2 MMP9 CCNA2 IL6 CYP1B1 CXCL10 COL3A1 MYC CCL2 PRKCB HMOX1 COL1A1 HEL-S-102 VCAM1 CCNB1 PMC3568185__F1 PGE2biosynthetic pathway COX1 COX2 PMC4307032__F2 Signaling Molecules: Hydrogen Sulfide and Polysulfide DAO PMC6258792__F4 CREB1 signaling is predicted to be altered by ID EGR1 JUNB PDYN PTGS2 ARC FOS EGR4 BTG2 KLF5 EGR2 BDNF CEBPB CREB1 PMC6282071__F3 Increased P2X4R expression after nerve injury via the actions of fibronectin in activated microglia CCR2 CR2 LYN MDM2 IRF8 CCL2 EIF4E PMC3259815__F8 Signaling through PAK in the hyperosmotic response pathway CDC42 PTEN PMC1892100__F1 Image showing the human insulin signaling pathway from BioCarta SOST RAF1 GRB2 GAB2 IRS1 PMC3180377__F9 Toll-Like Receptor 2 Pathway Regulates the Ppargc1a/b Metabolic Co-Activators in Mice with Staphylococcal aureus Sepsis TIRAP TLR3 TLR4 IRF3 IRF7 PPARGC1A TRAF3 TRAF6 IRAK4 MYD88 PMC7600476__F3 The major cell signaling pathways by resveratrol and/or curcumin in melanoma STAT3 BAX BRAF BCL2 PTEN MDM2 MTOR CTNNB1 PMC9587090__F2 Cellular senescence and acute kidney injury CDC2 CDK6 CDK2 CCND1 CDK4 PMC8931477__F1 Natural Products Against Renal Fibrosis via Modulation of SUMOylation SUMO3 SUMO2 SUMO4 SENP1 SMAD4 SENP6 HDAC2 CTNNB1 PMC5863447__F2 Hierarchical clustering analysis of all differentially expressed proteins (DEPs) (812 proteins at p ≤ 0.05 with ≥ 2 unique peptides) SHC4 APOD RETN GYS2 APOH HGFAC FASN SERPINA1 LIPE PRKAR1A GRB2 ACACA PMC7868824__F45 Targeting NFKB mediated cell signaling pathway and inflammatory mediators by 1,2-diazole in A549 cells in vitro TLR4 EGFR PMC3116111__F1 Graphical representation of the candidate genes involved in the pharmacodynamics of doxorubicin in a stylized cancer cell ABCC1 MSH2 ERCC2 GPX1 HEL-S-18 NFKB1 XDH ABCG2 ABCC2 TOP2A RALBP1 ABCB1 HEL-S-44 PMC8563895__F7 B2-adrenergic receptor regulates ER-mitochondria contacts CDC42 INF2 MCU PMC5969912__F3 Once and only once: mechanisms of centriole duplication and their deregulation in disease USP28 LATS2 CASP2 MDM2 RAC1 PMC8157545__F1 Efficacy of BRAF and MEK Inhibition in Patients with BRAF-Mutant Advanced Melanoma and Germline CDKN2A Pathogenic Variants CDK6 BRAF NRAS MDM2 CDK4 PMC11915076__F1 Oncogenic and tumor-suppressive roles of Lipocalin 2 (LCN2) in tumor progression STAT3 S1PR1 ATF4 IL6 LCN2 IL6R PMC3827506__F5 Signaling by innate immune receptors SYK NLRP3 NOD2 TRAF6 MYD88 PMC3217176__F3 Targeting the PI3K/AKT/mTOR pathway BAD GSK3B CCND1 PMC5280876__F3 Mesenchymal Stem Cell Derived Secretome and Extracellular Vesicles for Acute Lung Injury and Other Inflammatory Lung Diseases IGF1R VCAM1 PMC5501684__F6 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection TGFA MMP2 FGF2 PMC5207462__F2 Insulin signaling pathway PI3 GRB2 PMC5501684__F5 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection TH CD48 COA1 IL18 IL4 CP PMC5501684__F4 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection CD40 TH CAD CDA IL4 HEL-S-11 PMC4350910__F3 Pathway for the synthesis of the endocannabinoids AEA and 2-AG TRPV1 FAAH PMC3722525__F7 Antigen processing and presentation pathway and the cell cycle pathway LTBP1 BMPR2 SMAD1 DKFZp781O1323 CDC20 SMAD2 APC SMAD6 SMAD4 TGFBR1 TGFBR2 IFNG SMURF1 CD74 NOG SMURF2 DCN PMC5501684__F7 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection TGFA MMP2 TNF PMC2561291__F1 Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions TBK1 MAL IFIT2 IRAK1 IRF3 IRF7 SOCS3 TNF CXCL10 TRAF6 IRAK4 MYD88 TLR4 HEL-S-162eP PMC7941218__F3 GDF‐5 signalling pathway and regulation of GDF‐5 expression ACAN GDF5 TRPS1 DKFZp781O1323 SOX11 PITX1 APC GSK3B MSC SMAD4 COL2A1 CTNNB1 PMC5215890__F6 The p53-like Protein CEP-1 Is Required for Meiotic Fidelity in C. elegans HUS1 SP1 SPO11 SP4 SP3 SP7 SP2 SP9 SP5 PMC7278922__F2 Two distinct Fe/S cluster biosynthetic pathways exist in mitochondria (mitochondrial NFS pathway, left) and plastid (plastidial SUF pathway, right) in Arabidopsis NFU1 HSCB PMC2561291__F5 Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions TBK1 TRAF6 MYD88 PMC4449696__F2 Retinoid metabolism and the structure of retinoid receptors RARA CDK7 RBP4 PMC4760086__F2 Inflammation in SCD CXCL9 HMGB1 PIGF TLR4 CXCL1 VCAM1 CXCL10 CXCL8 PMC8009949__F6 Part of C21-steroird biosynthesis pathway HSD3B2 STAR CYP17A1 PMC4486424__F6 Ingenuity Pathways Analysis summary TP73 EGF WT1 BCL2L1 TGFB1 CASP8 TIMP1 AIP MEIS1 CDKN2B CCNC PMC11955613__F5 Pyroptotic osteocytes promote osteoclastogenesis GSDMD NLRP3 CASP5 CASP4 PMC4980649__F1 Main WNT/Beta-catenin pathway involved in cancer and stem cells ESRRB TCF3 APC SOX2 GSK3B CCND1 CTNNB1 PMC11955613__F2 Apoptotic and necrotic osteocytes promote osteoclastogenesis BAX CASP3 VEGFA PMC9319258__F5 Possible Cause for the Differential Expression of a Subset of miRNAs in Mesenchymal Stem Cells Derived from Myometrium and Leiomyoma LTBP1 TNC HSPG2 CDC23 SDC4 VTN NODAL MYC COL3A1 YWHAQ E2F4 CSNK2A1 COL4A1 COL4A5 MDM2 CCNB1 YWHAG COL1A2 SP1 ARHA SPP1 CD44 RBL1 CDKN1A PRKDC MAP3K7 CREBBP COL6A5 WASF2 SMURF2 ITGB5 PMC11955613__F4 Ferroptotic osteocytes promote osteoclastogenesis SLC3A2 GPX4 LPCAT3 FACL4 SLC7A11 PMC4617705__F4 Effects of CsA on the expression of genes involved in endoplasmic reticulum stress and FXR-regulated pathways in WT-PCLS and FXRKO-PCLS PTN APOB ACD ACACA PMC7299245__F1 Targets of new therapeutic options in beta-thalassemia GDF10 STAT3 SMAD1 TFR2 DKFZp781O1323 SMAD2 SMAD4 EPO HAMP HFE2 ERFE GDF3 BMP6 GDF11 HFE GDF1 PS1TP5BP1 PMC7240957__F8 Mechanism of cytochrome P450 (CYP450)-dependent metabolism of polyunsaturated omega-6 and omega-3 fatty acids involved in CKD progression TES LOX EPHX3 CYP2E1 EPHX2 PMC5846367__F2 Interplay between immune system and gut microbiota in homeostasis, tolerance, and inflammation IFNG TH TSLP APC IL33 PMC3773992__F2 Crosstalk between hedgehog signaling, Wnt/Beta-catenin signaling, notch signaling, and phosphoinositide 3 (PI3)-kinase/Akt pathway and targeting by norcantharidin (NCTD) DKK3 PGP SUFU DKK1 APC PTCH1 LRP5 JAG2 LRP6 SMO PMC7991087__F5 Summarizing Figure HMGCR TLR4 SREBF2 PMC6290143__F2 Role of the APC tumor suppressor gene in signaling expression of genes regulating the polyamine pathway APC FAP MYC PMC6307803__F6 The model of miR‐520b regulating NSCLC tumourigenesis SPOP GLI3 PMC7932307__F2 Nucleic acid immunotherapeutics that can activate the cGAS-STING signaling pathway CGAS IRF3 PMC5454811__F4 Schematic diagrams of (A) the BR biosynthesis pathway, (B) BR signal transduction pathway, and (C) auxin signaling transduction pathway BIN2 CS CPD PMC4031983__F8 MiRNA dependent regulation of DSB repair during cell cycle RAD51 BRCA1 BRCA2 IMPACT PMC3996470__F1 Receptor-mediated endocytic pathway in nonpolarized mammalian cells NPC2 NPC1 LDLR PMC7244267__F4 Significantly enhancing production of trans-4-hydroxy-l-proline by integrated system engineering in Escherichia coli MAL CIT PMC8882646__F1 Interaction of Mycobacteria With Host Cell Inflammasomes NINJ1 HMGB1 GSDMD NLRP3 AIM2 TNF PMC6541953__F2 Anti-inflammatory and antioxidant mechanisms of neuroprotection and neuronal function by ursolic acid LPO NQO1 MTOR PMC3021128__F7 Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7 MCM7 MCM3 MCM5 MCM6 MCM2 PMC2106369__F1 Schematic overview of the RANK-NFKB signalling pathway MAP3K7IP1 TRAF6 VCP PMC4737002__F1 Regulation of interconnected stem cell signaling nodes by the AR KLF4 STAT3 SMAD2 PTEN CCL5 PMC6536593__F5 Implication of hexosamine biosynthetic pathway on the NLRP3 inflammasome OGA OGT NLRP3 TXNIP IL16 IL1B PMC3694812__F1 Towards Systematic Discovery of Signaling Networks in Budding Yeast Filamentous Growth Stress Response Using Interventional Phosphorylation Data CDC42 NRG2 NRG1 TPK1 PMC3694812__F4 Towards Systematic Discovery of Signaling Networks in Budding Yeast Filamentous Growth Stress Response Using Interventional Phosphorylation Data CDC42 TPM1 NRG2 NRG1 TPK1 PMC7497261__F1 Different inflammasome complexes: (From left to right) Engagement of different TLR receptors leads to activation of IKKs, which in turn results in activation of NF‐KB signaling NLRC4 NLRP1 DPP9 HMGB1 PKN1 GSDMD NLRP3 PKN2 AIM2 ARHA PMC3419137__F3 Targets of the tumor suppressor gene miR-200 in regulation of the epithelial-mesenchymal transition in cancer SPON2 CDH2 ADAMTS15 HEL-S-2 CTSH LGALS3BP SPARC MERP1 CTSL CTSA CTSZ NID1 GUGU BMP4 ADAM15 TINAGL1 ADAM12 GGH PMC9134136__F2 Ductular reaction in non-alcoholic steatohepatitis LATS1 LATS2 HGF SMO CTNNB1 GLI3 PMC4698100__F8 Regulatory functions of STAT3 in cardiac Beta-adrenergic functions STAT3 CACNA1H ADRB1 SRC PMC4850140__F1 Tested Wnt-related genes and proteins and their functions in the canonical Wnt signaling pathway are shown here APC LRP5 LRP6 PMC8273435__F4 The F-BAR Family Member PSTPIP2 in Autoinflammatory Diseases PSTPIP2 CSK PSTPIP1 PMC3585432__F1 The Drosophila Hippo pathway FRMD6 LATS2 F2 AMOT ZYX RUNX2 PMC4669899__F2 Simplified outline of Insulin and AA/TOR signaling pathways RHEB TSC2 TSC1 PTEN PMC3515332__F1 Class I PI3K/Akt/mTOR axis pathway BAX BAD RICTOR FOXO1 PTEN IRS1 EIF4E PMC5475222__F2 Secreted T STAT1 EGR1 CXCL2 MBD3 MDM2 TRAF6 CAMLG ADA PMC5548997__F7 Involvement of BPA, BPS or BPF in the proliferation, EMT, and migration of MCF-7 CV cells via ER-dependent pathway CDH2 CCNE1 CCND1 PMC12121119__F3 Bridging role of hepatokines in AD and metabolic disorders IFNG ANGPTL3 SHBG GPX4 TLR4 FGF21 SMAD2 CREB1 SELENOP PMC6540965__F2 Relationship between middle-age obesity, glutamate excitotoxicity and increased risk of Alzheimer’s disease STAT3 MTOR PMC8704679__F2 JAK-STAT Pathway: A Novel Target to Tackle Viral Infections C6 IRF9 PMC7941705__F2 Anesthetic affect pro- and anti-cancer miRNA expressions leading to cancer biology changes GC MMP2 HIF1A MMP9 PMC9186411__F1 Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus CGAS NLRP3 SLC19A1 PMC8704679__F1 JAK-STAT Pathway: A Novel Target to Tackle Viral Infections TBK1 MAVS TANK IRF3 PMC4363231__F1 Potential canonical WNT signaling pathway- Resting state (a): SFRP4 binds free WNT molecules in the extracellular space and DKK binds the LRP co-receptor SFRP4 DKK1 APC LRP5 LRP6 CTNNB1 RSPO1 PMC9256749__F4 Piezo1 channel promotes the tumorigenesis of prostate through the Akt/mTOR pathway (adapted from 111) PIEZO1 MTOR CCND1 CDK4 PMC6737422__F1 SCD-associated oxidative stress pathways and antioxidant systems NOX5 TLR4 FES NOX4 HEL-S-44 PMC5662719__F6 Schematic working hypothesis NLRP3 IL16 ACE2 SPRY1 IL1B PMC7567162__F7 Tripterygium ingredients could inhibit multiple pathways, such as the NFKB pathway, JAK-STAT pathway, and PI3K-mTOR pathway, to regulate the hyperactive as well as pathogenicity biological functions in a various type of cells ( to ) APC IL2 IL6 IL1B PMC6534162__F2 Stimulating Cardiogenesis as a Treatment for Heart Failure CDC2 NRG1 CCNA2 PMC11842143__F1 Developmental signaling pathways regulating osteoblast differentiation SMAD1 DKFZp781O1323 SOX9 BMP4 BMP2 LRP5 SMAD4 LRP6 SMO RUNX2 RBPJ CTNNB1 PMC4292999__F5 Co-expression of the Wnt signaling pathway with CITED2 in spondyloarthritis (SpA) WNT10B CITED2 FZD4 ROR2 WNT1 PMC6988322__F5 SMARCD1 nearest-neighbor adjacency subnetwork with the glucocorticoid receptor response pathway SMARCC1 SMARCC2 SGK1 CREBBP EP300 SMARCD1 NR3C1 CP SMARCA4 PMC5733726__F1 Inborn errors of immunity underlying fungal diseases in otherwise healthy individuals RASGRF1 HRAS STAT3 IL17RC STAT1 BCL10 EBP CXCL1 JAK1 IL23R IL1B CARD9 PMC9641109__F7 Identification of candidate hub genes correlated with the pathogenesis, diagnosis, and prognosis of prostate cancer by integrated bioinformatics analysis HEL-S-22 FMO5 CXCL12 COMP CALD1 ITGB4 SV2B KCNJ8 GPX3 CCL2 MYLK KCNJ3 MME ANGPT1 CCND2 PDGFC PTGS1 KCNMB1 HLA-DMB CAV2 AOX1 GSTM2 RRM2 GSTM5 PTGS2 VEGFA COL13A1 COL2A1 HEL114 PPP1R14A GSTM1 GSTM3 PTGIS COL4A6 LAMB3 CALM1 NPR2 EDNRB THBS4 COL9A2 PMC3078731__F3 Central prostate cancer-related processes and their miRNA-mediated regulation PTEN RHO MDM2 PMC6835793__F1 The CD40-ATP-P2X7pathway links cellular responses in Müller cells with the induction of inflammatory responses in bystander microglia/macrophages in DR CD40 NOS2 CCL2 IL1B PMC8300779__F2 Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs RBX1 KEAP1 PMC5542024__F9 Graphical Summary ARHGEF1 CSK ARHA PMC2259254__F2 Balance between muscle hypertrophy and atrophy depends on whether protein synthesis is more active than degradation or vice versa IGF1 GSK3B MTOR PMC8766493__F7 Fatty Acid Signaling in Islet Beta-Cell Adaptation to Normal Pregnancy TG PC FFAR1 PMC6966572__F2 PARP inhibitors in combination with other therapeutics CXCL9 TBK1 APC CCR7 IRF3 CXCL10 PMC12162639__F1 NLRP3 inflammasome signaling pathway GSDMD NLRP3 MYD88 PMC7594482__F1 Osteogenesis regulating signaling pathways SMAD2 ROR2 SMAD4 RYK RHO RUNX2 CTNNB1 FGFR2 FRAT1 CBL FOXO1 SUFU FGFR1 HEL-S-11 SMO PTH GRB2 SOX4 PMC6720185__F1 Stress and depression drive an increase in corticotropin releasing factor (CRF) that activates mucosal mast cells and leads to an increase in gut permeability, coupled to gut dysbiosis and decreased butyrate production TES P2RY1 CYP2C19 AANAT AHR ASMT CYP1B1 BDNF PMC2858440__F5 Four flux sensors of the in silico cell CRP CRAT PTS FAP PMC12162639__F2 Inflammatory regulation in the process of venous thrombosis formation TF VWF VCAM1 PMC5945810__F2 Protein regulation of the TLR2/1 signaling pathway SOCS1 TRIM13 MAP3K7IP1 TIRAP IRAK1 IRAK2 TRAF6 CYLD IRAK4 IL1B MYD88 PMC7140927__F1 Sensing mechanisms for abiotic stress in plants ERF ICE1 SOS1 SOS2 EGR2 PMC7080653__F1 T1DM candidate genes acting at the beta-cell level mainly play a role in three pathways (): (1) Regulate the innate immune response and pathways important for antiviral activity, such as the type 1 IFN signaling pathway (IFIH1, TYK2, PTPN2) ERBB3 GLIS3 STAT1 CLEC16A BACH2 TNFAIP3 CTSH IRF9 STX4A JAK1 TYK2 PMC7848346__F1 Traditional (right hand side, orange background) and alternative (left hand side, blue background) renin‐angiotensin‐aldosterone system pathway DAP ACE2 PMC3245020__F3 Disease/drug mapping is the process to map all known disease genes (pink) and all known drug targets (light blue) against all KEGG pathway maps LPL IDE BAD APOE GSK3B CASP3 SNCA APP TNF FADD PMC7048131__F3 Advances of the STAT3 signaling pathways involving breast cancer proliferation and apoptosis STAT3 SMYD2 TRIM14 BAX EGF CCL18 DPF3 EGFR WWOX TFEB PMC8282123__F1 Endocrine Influence on Cardiac Metabolism in Development and Regeneration GC HEL-S-5 PMC7048131__F2 Advances of the STAT3 signaling pathways involved in breast cancer progression STAT3 SMYD2 EGF OSM COX2 EGFR HDAC6 PMC4264574__F1 TLR4 signaling cascade HMGB1 TIRAP IL16 TLR4 CD14 IRF3 IRF7 MYD88 PMC3012138__F3 A network of hits highly enriched in cell cycle-related genes MYLK2 RAN ATR PKIB RPL31 FRK TRPC4 APC PTK7 DGKB PEX26 EEF2K APOA4 NR2A1 GNRHR PMC7048131__F5 Advances of the STAT3 signaling pathways involving breast cancer chemoresistance STAT3 LIF PMC7048131__F4 Advances of the STAT3 signaling pathways involving breast cancer metastasis STAT3 RHOU TIEG2 VASP OSM PIM1 WWOX TFEB MMP2 MMP9 ARHGAP24 PMC7048131__F1 Classical IL-6/STAT3 signaling pathway in cancer cells STAT3 EGF EGFR PMC5945810__F1 TLR2/1 signaling cascade and respective regulatory nodes MAP3K7IP1 TIRAP IRAK1 IRAK2 TRAF6 IRAK4 IL1B MYD88 PMC9582503__F1 MicroRNA and Their Potential Role in Conjunctival Disorders RAN DGCR8 DROSHA PMC3165102__F1 TGFB/SMAD/GLI2 signaling axis in cancer progression and metastasis PTHLH SUFU SMAD4 SMO CCND1 PMC2634812__F5 Schematic of counterbalancing and dose-dependent regulatory forces that act on T-cell precursors through the ETP and DN2 stages ID2 PAX5 SPIB NOTCH1 GATA3 PMC2634812__F4 Myeloid diversion pathways for advanced pro-T cells by re-introduction of C/EBPA or PU.1 MYB ETS2 ID2 BCL2 EGR2 BCL11A ATL1 NOTCH1 LCK GATA3 MPO PMC8307416__F5 Identification and Roles of miR-29b-1-3p and miR29a-3p-Regulated and Non-Regulated lncRNAs in Endocrine-Sensitive and Resistant Breast Cancer Cells PAX3 TRIR SMAD1 ID2 SMAD2 PML SOX2 SMAD4 TBX5 RUNX2 GATA3 ID3 CTNNB1 FOXM1 EDNRA KLF5 CCND1 PMC2634812__F3 Stepwise respecification of ETP and DN2 cells by GATA-3 overexpression GATA2 THY1 CPA3 GATA3 PMC8584434__F4 Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications TF HEL-S-62p TFPI ACE2 PMC5697340__F1 Stages of innate lymphoid cell (ILC) development CXCR6 ID2 IL2RA TOX ZBTB16 NFIL3 GATA3 PMC11203986__F7 HIRA-associated pathway KPNA2 MYC HIRA PMC11203986__F6 CAF-1-associated pathway ASF1A HDAC1 PCNA HIRA PMC4058004__F1 Simplified biotransformation scheme of tamoxifen in man. Tamoxifen is mainly N-demethylated to NDM-TAM and subsequently 4-hydroxylated to endoxifen UGT1A4 CYP2C9 CYP3A4 PMC11203986__F8 NAP1L1-associated pathway CDK6 CCND1 CDK4 PMC8817856__F8 ROS/GRK2/HIF-1A/NLRP3 Pathway Mediates Pyroptosis of Fibroblast-Like Synoviocytes and the Regulation of Monomer Derivatives of Paeoniflorin ADRBK1 GSDMD HP PMC9274484__F4 Gut microbiome in gastrointestinal cancer: a friend or foe? TIGIT TLR4 COIL TNF CTNNB1 MYD88 PMC6135677__F7 Sketch diagram illustrated the target genes by the selected miRNAs in ROS-AKT-cyclinsenescence pathway CCND2 AKT3 GSK3B CDK2 CDK4 PMC9274484__F3 Gut microbiome in gastrointestinal cancer: a friend or foe? LTA CXCR6 COX2 TLR4 CXCL16 MYD88 PMC2077853__F9 Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation GDNF LYN SRC RET PMC4153443__F1 The mammalian circadian clock FBXL3 RORA PMC9274484__F2 Gut microbiome in gastrointestinal cancer: a friend or foe? BRCA1 PTEN NOD1 MTOR AXIN2 CTNNB1 PMC9277653__F4 Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment TF EGF EGFR ERG MTOR PMC8955937__F11 WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders HEL-S-133P HK2 WWOX HIF1A PMC4499569__F2 Neuroprotective cross-talk involving the cytoprotective PI3K/AKT pathway PINK1 IGF1 IRS1 PMC5840486__F1 Schematic illustration of the main hedgehog (Hh) pathway components SUFU PTCH1 SHH SMO SNAI3 GLI3 PMC3312480__F1 Schematic view of potential targets and site of action of some biologics in IBD TH APC SMAD4 PMC8168453__F2 Schematics of the TIM3/Gal9 signaling pathway in T cells ZAP70 IFNG HEL-S-92n FYN LAT CSK LCK PMC8168453__F4 Schematics of the TIM3/Gal9 pathway in innate immune cells IFNG TLR4 APC PMC9409562__F1 Type I interferons during host–fungus interactions: Is antifungal immunity going viral? MAVS TLR3 STAT2 PSMB8 PDC SP110 TYK2 PMC8955937__F10 WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders HEL-S-133P HK2 WWOX HIF1A CS PMC10180405__F3 BMP-2 and Wnt/Beta-catenin signaling pathways participate in the pharmacological activity of naringin in mediating osteogenic differentiation DKFZp781O1323 APC LRP5 SMAD4 LRP6 TCF4 RUNX2 AXIN2 CTNNB1 PMC12123823__F1 Mechanisms underlying NET formation RIPK3 GSDMD CDK6 MLKL CDK4 MPO PMC7697962__F2 Top two networks constructed by ingenuity pathway analysis (IPA) showing interactions between the top 100 differentially expressed genes (DEGs) in the dendritic cells (DCs) from patients with allergies MMP14 MAPK13 CREM ZNF180 ERG PROC EHD1 PMC10525949__F6A Transcriptomics Reveal the Effects of Breeding Temperature on Growth and Metabolism in the Early Developmental Stage of Platax teira LPL UBC UCP1 HEL-S-28 PLTP SHE CPT2 PMC8222468__F2 Extracellular vesicles in podocyte autophagy in kidney disease RHEB MLST8 EEF2K TSC2 TSC1 ATG14 PML BNIP3 EEF2 PTEN MTOR PMC3117856__F3 MAPK signaling pathway MAX ECSIT EGF NGF FAS c-fgr CRKL GCK FLNA FOS PMC2994991__F6 Reporter gene assay for HIF-1 activity HIF1A PMC4946894__F1 Apoptosis pathways in various organisms BAX TNF SKI PMC8616058__F1 Exosomes in Ageing and Motor Neurone Disease: Biogenesis, Uptake Mechanisms, Modifications in Disease and Uses in the Development of Biomarkers and Therapeutics TH PLD2 RAB35 UBB PMC6314011__F3 The interplay between intrinsic (i.e., circadian clock) and neurohumoral factors in circadian control of both metabolism and redox tone DGAT2 HK2 PIK3R1 PMC2832945__F7 Proposed mechanism for B2M mAb inhibition of AR and cell proliferation, survival, and progression through a MAPK/SREBP-1 signaling pathway in prostate cancer cells FAS B2M PMC5088563__F1 Signaling cascades implicated in developmental cell death and tissue homeostasis RIPK3 STAT3 TLR3 GPX4 TLR4 BCL2 RIPK1 PMC6390240__F4 Modules of core PPI networks of baicalein against HCC HSP90AB1 CDC2 FUS HEL-S-103 EGFR TUBB CAND1 TRIM28 BRCA1 YWHAQ NTRK1 ERBB2 CDK2 EEF1A1 MDM2 PMC5168844__F1 Network structure for RAS signaling pathway in Head and Neck Squamous Cell Carcinoma (HNSC) MAPK1 BAD RAF1 EGFR NFKB1 PRKCA KIT MAPK9 GAB2 PMC6964830__F8 Functional network of proteins in stage 3 breast cancer samples MOB1A WWC1 FKBP9 Meflin PMC8757397__F1 Pathophysiology of COVID-19-associated coagulopathy CRP TF TFPI PLG IL6 CCL2 TNF ACE2 IL1B PMC2909654__F5 Examples of human disease phenotype correlations in the absence of metabolite sharing but detected by flux correlations ASL OTC FECH UROD UROS PMC3820238__F1 Schematic overview of TGFB signaling TF LIMK1 SMAD2 SMAD6 NODAL RHO PMC4836751__F5 Transcriptional Profiling of Ileocecal Valve of Holstein Dairy Cows Infected with Mycobacterium avium subsp. Paratuberculosis ZAP70 ICOS JUN CD37 LAT CBLC CD33 GRB2 FOS LCK PMC8362800__F2 SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors SPOP SUFU PTCH1 SHH SMO PMC6557983__F1 Pathogenesis of hRSV and molecules with a biomarker potential induced in the airways during hRSV infection TH TSLP CXCR1 TLR3 TLR4 IL33 IL8RB MYD88 PMC2837270__F8 Seoul virus suppresses NFKB-mediated inflammatory responses of antigen presenting cells from Norway rats CD40 IL10 TNFRSF1B LTA CASP8 NFKB2 TNFSF6 IKBKE IRF1 IRAK2 CCL2 CSF3 MYD88 TLR1 TNFSF10 IFNA1 PMC8395571__F7 Pathway-targets analysis CDC2 BAX BIRC5 RUNX1T1 CHEK1 CCNA2 KDR CCNB1 TOP2A PMC3370249__F7 Proposed FasL-Met signaling pathway TH STAT3 CCND1 PMC7774657__F1 Aspirin’s role in colorectal cancer prevention Cyclooxygenase (COX) dependent pathway (Left panel): Inhibition of COX-1 in platelets and COX-2 in epithelial cells COX1 CXCL1 TNF CTNNB1 PMC6468861__F2 miRNA biogenesis pathway and various single nucleotide polymorphisms (SNPs) occurring at different steps of the pathway that play a pivotal role in prediction of breast cancer risk development DGCR8 AGO2 DROSHA PMC9288680__F10 Macrophage-derived apoptotic vesicles regulate fate commitment of mesenchymal stem cells via miR155 BGLAP SMAD2 RUNX2 PMC10757365__F3 Immune checkpoints in antitumor response: a potential antitumor immunotherapy STAT1 CD80 APC IRF1 JAK1 PMC10376142__F1 Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms ANTXR1 FURIN PMC3346695__F2 Cell signaling pathways involved in ischemic postconditioning BAX BAD FAS GSK3B PTEN PMC9029764__F2 Dangerous Liaisons in the Oxidative Stress Response to Leishmania Infection TLR3 IL6 CCL5 CXCL10 PMC6148086__F8 Schematic summary TGFB1 MTOR PMC6964830__F5 Functional network of proteins in stage 2 breast cancer samples, (confidence level = 0.150) MOB1A FKBP9 Meflin PMC4193347__F6 Germline PTEN Mutation Cowden Syndrome: An Under-Appreciated Form of Hereditary Kidney Cancer FH HGF PTEN FLCN VHL SDHD RHEB TSC2 SDHB TSC1 TFEB FNIP2 FNIP1 SDHC PMC7464713__F7 Implemented model of the Wnt-independent Beta-catenin pathway SOX17 TCF4 CTNNB1 PMC8196972__F6 Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis CCR2 CCL2 CD34 PMC3817731__F3 Activation of the EGFR pathway and the consequent engagement of the Ras/Raf/MAPK and PI3K/Akt pathways EGF EGFR GRB2 PMC2987484__F1 Pathway analysis on differentially expressed genes PTPN5 LOC51064 CHRM3 HTR2A CDC42EP4 MPHOSPH6 STK32C EFNA1 TACSTD2 CCKBR FYN SLIT2 DRD2 MME PCSK1 PDE1B APP USP24 MGMT SMARCA4 PCDH7 SPRY4 PTP4A2 LIMK1 MAK RPL21 BACE2 S100A2 GPR3 TNF SPP1 NEFH SST HEL-117 THOP1 RAB15 HEL-S-75p GPX7 PMC8517841__F6 Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway SLFN11 JAK1 TYK2 PMC2435243__F9 Several signaling pathways work together in the TGFB1-induced expression of CCN2/CTGF in primary human gingival fibroblasts CDC42 LPA HEL-S-62p RHO PMC3858190__F4 Pathways involved in sensing and responding to double-stranded RNA and other pathogen-associated molecular patterns were suppressed by SMD CD40 JUN LTA MAVS IL4 FADD PMC7563728__F1 Metabolic pathways and Snail target enzymes of catabolic metabolism HEL107 FBP2 F2 FBP1 TIGAR PMC3858190__F9 Ingenuity pathway analysis of differences between LPS and LPS + SMD (300mg/kg) with regard to reproductive hormones GAS7 MRPS6 PPIF GEM HK2 ST6GAL1 ACAP1 GRWD1 PFKFB2 WDR26 TCEAL8 ATAD3A UGDH CYFIP2 MYO1C CEP170 PHF5A UCK2 YTHDF2 GRB2 GJA1 DHRS3 PMC10987845__F1 Glycan biosynthesis mutants were screened for immune stimulatory properties CD80 GAL PMC3169412__F1 Fatty-acid biosynthetic pathway for R FAS FBL FASN FES FOS PMC6771463__F6 Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma GRPR PTEN MTOR PMC6119869__F3 The paradoxical HH pathway SUFU SHH PMC6119869__F2 The HH signalling pathway SUFU PTCH1 SMO PMC6982256__F5 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents RHEB TSC1 ULK1 PMC8275186__F1 Coordinated Cut and Bypass: Replication of Interstrand Crosslink-Containing DNA RAD18 FANCD2 ID2 PCNA FANCM PMC3397315__F4 Summary of ion channel targets of the GSK-3 pathway KCNQ2 PMC9048451__F2 Abnormal synaptic plasticity and impaired cognition in schizophrenia TH GLS HTR4 DDC PMC5999603__F8 The model of linc00462 regulation in PC TGFBR2 OSM SMAD2 TGFBR1 PMC8883537__F5 Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma SOCS1 STAT3 TG STAT5B JAK3 COIL PTPRC SH2B3 PMC6813250__F3 JA-mediated cold and freezing stress responses in plants ICE2 ICE1 PMC5666906__F6 The impact of EGFR-ERK pathway on the type I interferon response in human keratinocytes IFNK STAT1 EGFR IFIT1 IRF1 IFIT2 CCL2 PMC8573303__F3 Effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection CD40 CYP27B1 CD80 CCL22 PMC5328970__F3 Sema3A signaling in bone remodeling FARP2 SEMA3A PLCG2 NRP1 ARHA CTNNB1 PMC6119869__F4 Mechanisms of resistance to SMO inhibitors SUFU PTCH1 SMO PMC6385204__F7 Angiomotin-p130 inhibits Beta-catenin stability by competing with Axin for binding to tankyrase in breast cancer TNKS APC GSK3B CTNNB1 PMC4538064__F3 Insights into the molecular mechanisms of methylmalonic acidemia using microarray technology MAX FAS MOS KEL NF1 CASP3 CD14 ATM GCK TNF FLNA TRAF2 PMC3870411__F1 TNF Signals through TNFR1 and TNFR2 receptors (A) but abnormalities in this signaling pathway in autoimmunity (B) can favor a pathway of selective apoptosis due to a variety of protein signaling defects TRADD TNF TRAF2 FADD PMC3273665__F2 SREBPs in the innate immune response NLRP3 TLR3 IFNAR2 TLR4 IFNAR1 TLR9 IL1B MYD88 PMC9599708__F3 Copper-Dependent Kinases and Their Role in Cancer Inception, Progression and Metastasis ATG101 BAD ULK1 MDM2 ULK2 PMC7053069__F7 Schematic of CPT’s anti-inflammatory mechanism in LPS-stimulated RAW264.7 cells KEAP1 TLR4 MYD88 PMC5680590__F7 CAV1 orchestrates the TGFB response in HCC EGFR BMF NOX4 PMC9162579__F4 Genome-Wide Mutant Screening in Yeast Reveals that the Cell Wall is a First Shield to Discriminate Light From Heavy Lanthanides ALG6 ALG3 PMC5875422__F8 Schematic shows the relationship between neuronal and oligodendrocyte metabolism SGMS1 OLIG2 NAT8L UGT8 ASPA PMC6103739__F7 Schematic diagrams of SOS1 activation EGFR GIP GRB2 PMC4344206__F1 Platelet signaling pathways SYK ORAI1 COX1 STIM1 GC PMC9531149__F3 Role of extracellular granzyme B in wet age-related macular degeneration and fuchs endothelial corneal dystrophy RPE PMC9201572__F15 Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGFB/Smads Signal Transduction HEL113 SMURF1 SMAD2 SMAD4 SMURF2 SKI PMC3666437__F5 Regulation of upregulated miRNAs on the downregulated mRNAs in antigen processing and presentation pathway and p53 signaling pathway ATR REST CANX PERP B2M MTOR TNF MYC HEL-S-99n IFNG CDK6 BCR PIGS CDK4 PMC10542959__F4 FOXM1 may be involved in diabetic nephropathy by regulating signaling pathways such as NFKB/NLRP3 and Wnt/Beta-catenin FOXM1 NLRP3 SIRT4 CCND1 CTNNB1 PMC3717793__F1 Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 RBX1 TOB1 FOXO1 SKP1 SKP2 PMC10542959__F3 FOXM1 is involved in regulation of diabetes-related inflammatory responses IFNG FOXM1 CX3CL1 MTOR TNF PMC11927582__F3 Sufu plays an important regulatory role in Toll-like receptor (TLR)-mediated inflammatory responses NLRP3 SUFU IRAK1 TRAF6 IRAK4 MYD88 PMC11927582__F2 LAT in the TCR pathway enhances signal transduction by sequestering inhibitory factors through a LLPS mechanism LAT GRB2 FOS PMC8350386__F1 MicroRNAs in Transforming Growth Factor-Beta Signaling Pathway Associated With Fibrosis Involving Different Systems of the Human Body BAMBI TRAF4 SMAD2 SMAD6 SMAD4 TRAF6 TGFBR1 PMC6766659__F6 Pathways that mediate the effects of NANOG on COL3 expression by senescent cells SMAD2 SMAD6 SMAD4 COL3A1 PMC9199556__F6 Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States TRPV2 MPO PMC8534183__F5 New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NFKB Signaling-Mediated Inflammatory Responses in Human Monocytes ABCB6 STEAP3 TLR4 FECH TNF ABCB10 PMC5868815__F4 In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases HEL-S-22 EGF PIK3CA BAD SOS1 AKT3 CYCS BRAF SMAD4 PTEN MTOR CTNNB1 TGFBR2 RB1 E2F3 MDM2 CCND1 MAPK1 CASP9 SRD5A2 MSH6 JUN APC KRAS RAC1 AXIN2 FOS HEL-S-125m CDKN1A NFKB1 IKBKB CASP3 CREBBP CDK2 BCL2 MAP2K1 GRB2 LEF1 PMC5868815__F3 In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases EGF PIK3CA BAD SOS1 ABL2 GSK3B BRAF NRG3 MTOR MYC NCK2 PRKCB NRG4 EREG SHC4 MAP2K4 PI3 BTC SRC JUN KRAS NRG2 CRK NRG1 CBL CDKN1A MAPK10 GRB2 PMC9029562__F4 Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase DBH TYRP1 PMC3107200__F8 Chk2 and p53 Are Haploinsufficient with Dependent and Independent Functions to Eliminate Cells after Telomere Loss ATR ATM SKI PMC5383719__F3 Low-avidity signaling of B2-integrin regulates toll-like receptors (TLR) signaling in macrophages SYK TLR4 CD2AP SRC MYD88 PMC2852602__F2 TLR/IL-1R signalling pathways TIRAP TLR3 CD36 TLR4 TLR9 TLR5 IRAK2 TLR7 TRAF3 TRAF6 IRAK4 MYD88 PMC6274341__F1 Isoprenoid biosynthetic MVA pathway in the plant cell IPP MVP MVK PMC9639265__F1 Endoplasmic reticulum stress targeted therapy for breast cancer ATF4 XBP1 PMC4209143__F2 Macroautophagy is regulated by several signalling pathways RHEB MLST8 CAD HEL-S-11 CALCA INS DEPTOR PMC9639265__F3 Endoplasmic reticulum stress targeted therapy for breast cancer ATF4 MTOR XBP1 PMC9639265__F2 Endoplasmic reticulum stress targeted therapy for breast cancer STAT3 ATF4 TNF XBP1 PMC9046545__F4 Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review FGFR4 FGFR1 FGFR3 FGFR2 PMC9046545__F3 Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review CBL FRS2 GRB2 PMC9639265__F4 Endoplasmic reticulum stress targeted therapy for breast cancer HIF1A ATF4 MYC XBP1 PMC9240045__F7 Schematic time-course changes in cellular processes in phosphorylase liver isoform knockdown (shPYGL) and control (shControl) U87MG glioblastoma (GBM) cells following high dose ionising radiation (IR) GAA PYGM PYGL PYGB GYS1 PMC9537356__F5 On-Target Side Effects of Targeted Therapeutics of Cancer NRG1 CSK MTOR PMC5746461__F5 Serotonin neuron development: shaping molecular and structural identities GATA2 SLC17A8 SLC22A3 HCRTR1 LPAR1 DDC MAOA GATA3 LMX1B HTR1B ADRA1B INSM1 SLC18A2 5HT1A EN1 TPH2 GRIA4 PMC4322535__F3 Signalling pathway of renal tumour-propagating cell membrane markers and “cancer stem cell” markers CD44 SMAD1 DKFZp781O1323 HDAC5 CXCR4 CTNNB1 PMC4209143__F3 Macroautophagy in the immune system BCR TLR9 PMC2672206__F7 Regulation of osteogenic differentiation of MC3T3-E1 cells by substrate rigidity HEL-S-62p ARHA RUNX2 PMC8651982__F5 T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development UBR5 HIPK2 EGFR LEF1 PMC9372833__F5 Occurrence of MYD88L265P and CD79B mutations in diffuse large b cell lymphoma with bone marrow infiltration: A case report LPL SYK CD79B CD79A CARD11 IRAK1 MTOR TRAF6 IRAK4 MYD88 TG BTK BCL10 LYN PMC8836162__F4 EphrinB2–EphB4 Signaling in Neurooncological Disease EGFR DLL4 VEGFA PMC8836162__F2 EphrinB2–EphB4 Signaling in Neurooncological Disease HRAS SOX1 RRAS ARHA PMC8195694__F1 Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies TMPRSS2 MAVS TLR3 TLR7 ACE2 PMC11039848__F2 How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography? CYP8B1 BAAT CYP7A1 CYP7B1 CYP27A1 PMC4624093__F1 Biomarkers of Angiogenesis in Colorectal Cancer VEGFB VEGFC PIGF VEGFA SRC PMC5705427__F3 Psoriasis: A mixed autoimmune and autoinflammatory disease CARD14 ERAP1 CXCL1 CXCL2 PMC4437805__F1 Wnt signaling pathways NOTUM GSK3B LRP5 LRP6 RYK ARHA RAC1 CTNNB1 PMC9413544__F1 Neuroprotective Natural Products’ Regulatory Effects on Depression via Gut–Brain Axis Targeting Tryptophan KMO AANAT ACD PMC10648403__F6 Expression profiles of genes involved in the phenylpropanoid biosynthesis pathway CPA1 CAD CPA3 PMC8910922__F1 Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases CYS1 TG CDK5 KEAP1 PMC3066660__F6 Significantly expressed genes in cytokine–cytokine receptor interaction pathway disturbed by SM at different time points FLT3 FAS HGF LEP LTBR OSM NGFR EPO TNF KITLG SST MPL EPOR PRL TPO AMH EDAR TNLG7C ACR CCL1 CCL17 PMC5094708__F6 Mesenchymal Stem/Stromal Cells under Stress Increase Osteosarcoma Migration and Apoptosis Resistance via Extracellular Vesicle Mediated Communication FASN PMC5132145__F4 Phagocytosis of apoptotic corpses CDC42 TRIO ARHG APC EPN1 MTM1 FERMT2 PMC5850397__F1 Mechanism of apoptosis induction by Vesicular stomatitis virus (VSV) in the infected cell RAE1 NUP98 PMC4703580__F1 Negative regulation of TLR signaling in myeloid cells—Implications for autoimmune diseases SOCS1 TREM2 ATF3 TIRAP FOXO1 TRAF6 MYD88 PMC3888942__F6 Axon navigation pathway targeting by miRNAs that differentially associate with Ago2 in an activity-dependent manner ROBO3 PLXNA2 ROCK2 PLXNB2 LIMK2 L1CAM EPHB1 ROBO1 ARHA RHO KRAS RAC1 ROBO2 EPHB2 EFNB1 CDK5 FYN SLIT2 FES CXCR4 RND1 SEMA7A PMC5951297__F4 Identified pathway between EGFR and JUN for Loi’s breast cancer dataset MAPK1 JUN CCNE1 EGFR SMAD2 SMAD4 NCOA1 LCK PMC2645904__F3 Schematic representations of potential signaling pathways involved in serum-deprived retinal ganglion cell-5 cells ALB IFNG EGF DNASE1 NR1C1 TEAD2 UXS1 RXRA PPARGC1A FOS ACADM PMC3116645__F1 Mammalian target of rapamycin (mTOR) signaling pathway RHEB MLST8 RICTOR IGF1 MTOR IRS1 EIF4E PMC6349890__F7 Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factorB and NLRP3 inflammasome signaling pathway TEC NLRP3 PMC6933909__F8 Schematic representation of the working model E2F8 PTEN MTOR NOTCH2 PMC2779188__F1 Genes involved in the vitamin D pathway VIT NR1i1 CYP2R1 IL10 CYP24A1 GC IL1RL1 CYP27A1 PMC8895170__F3 Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease LPL TG ANGPTL3 GPIHBP1 PMC5168844__F2 Network structure for PI3K signaling pathway in Lung Adenocarcinoma (LUAD) MAPK1 CASP9 CCNE2 TSC2 NFKB1 CDKN1B PRKCA BCL2L11 MYC HEL2 PMC5216781__F4 Overexpression of TELO2 decreases survival in human high-grade gliomas PIK3CA ATR RUVBL1 EGFR TTI1 ATM MTOR PMC5241525__F1 Several signalling pathways can induce epithelial-mesenchymal transition in pancreatic cancer cells for example Notch, transforming growth factorB, Midkine, hypoxia-inducible factor-1A and tumor necrosis factorA TGFB1 HIF1A PMC3084000__F1 Glioma-Associated Oncogene Family Zinc Finger 1 Expression and Metastasis in Patients With Head and Neck Squamous Cell Carcinoma Treated With Radiation Therapy (RTOG 9003) FOXM1 DISP2 HHIP CCND2 PTCH2 SUFU PTCH1 DISP1 SMO GLI3 PMC5009320__F5 3′-hydroxy-3,4,5,4′-tetramethoxystilbene, the metabolite of resveratrol analogue DMU-212, inhibits ovarian cancer cell growth in vitro and in a mice xenograft model RFWD2 BAX CASP9 FAS SIAH1 CASP8 PERP PTEN MTOR TSC2 CASP3 CDK2 PIGS MDM2 PMC3021097__F2 Functional significance of itpkc_3 on ITPKC mRNA and Ca2+/NFAT pathway APC GC HEL-S-11 ITPKC PMC4703580__F5 Negative regulation of TLR signaling in myeloid cells—Implications for autoimmune diseases TREM2 SYK TNF MYD88 PMC3919687__F6 Kinetic changes in gene expression of selected components of Th2 responses SOCS1 STAT3 GATA1 JAK3 MAF TYK2 PMC3919687__F5 Kinetic changes in gene expression of selected components of the Wnt/Beta-catenin signaling pathway in aging CD8+ T cells APC GSK3B LRP5 LRP6 SMO WNT10A LEF1 CTNNB1 PMC5417249__F1 Shared coregulator GRIP1 in the GR and type I IFN signaling networks TLR3 IFNAR2 TLR4 IRF9 GRIP1 IFNAR1 IRF3 IRF7 JAK1 TYK2 MYD88 PMC4136196__F5 Coinfection of Filifactor alocis with P PPIB PTMS HNRNPK AHNAK PABPC1 PMC9501144__F5 Resveratrol and Some of Its Derivatives as Promising Prophylactic Treatments for Neonatal Hypoxia-Ischemia BAX BDNF NRF1 SIRT1 PMC8181394__F3 Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy HMGCR SQLE LDLR HEL-S-11 PPAN PMC8181394__F2 Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy ACAT1 HMGCR SQLE PMC6598098__F6 Putative C4pathway in Alloteropsis semialata MAL PC PMC4208677__F4 Ingenuity canonical pathway analysis STAT3 ATR CCR5 BRCA2 SOCS3 PLK1 FANCA TRAF6 BLM FANCC FANCE FANCG IFNG FANCD2 STAT1 BACH1 ATM ATF1 CCR1 ARG2 RAD51 MSH2 SP1 TNF BARD1 MRE11A BRCA1 JAK1 LBP TYK2 PMC2678071__F1 Graphical representation of the gp130/JAK/STAT pathway OSM LIF SOCS3 PMC12144116__F0 GAS6/AXL signaling promotes M2 microglia efferocytosis to alleviate neuroinflammation in sepsis-associated encephalopathy STAT3 SP1 AXL RAC1 PMC8855423__F6 Lovastatin Inhibits RhoA to Suppress Canonical Wnt/Beta-Catenin Signaling and Alternative Wnt-YAP/TAZ Signaling in Colon Cancer GSK3B ARHA CTNNB1 PMC3245506__F4 Network of differentially expressed genes in HMGA1 transgenics at 12 months (nonparametric approach) ICOSLG IL10 HLA-DOB IL18R1 HMMR GAD1 CD5 ST8SIA1 PDE4B MUXA HMGA1 KPNA3 TFPI YWHAQ EBI3 CD200 ST18 MB HCTP4 KPNA1 PMC10380785__F3 Lignin, the Lignification Process, and Advanced, Lignin-Based Materials CAD STS PMC3245506__F3 Network of differentially expressed genes in transgenics at 2 months (parametric and nonparametric approaches) MAX CXCR3 CD80 LTA IL18R1 IRF1 IL2RA MTSS1 B2M ATF2 PRKCH DIRAS3 NCR1 CD44 GZMM HMGA1 HMGCR FCRLA PSEN2 APP TRAF2 GHR PMC3245506__F2 Network of differentially expressed genes in HMGA1 transgenics at 2 months (parametric approach) CD80 KRT10 FGF13 LTA IRF1 IL2RA PRKCH INSIG1 ID3 NCR1 PRF1 HMGA1 PSEN2 APP UNK PMC3245506__F1 Network of differentially expressed genes in HMGA1 transgenics at 2 months (nonparametric CAM approach) CD244 CDC73 CST7 HEL57 GZMA ST8SIA1 PRTN3 CTSG PRKCH MPO NCR1 RB1 HMGA1 ELANE MB BCL6 PMC3245506__F6 Network of differentially expressed genes in transgenics at 12 months (parametric and nonparametric approaches) CD2 VAV3 FCER2 HMMR MYBL2 RRM2 APC CR2 ST8SIA1 CCNA2 CDKN2A CCNE2 CCNG1 S1PR3 TFRC HMGA1 KPNA3 RAPGEF1 APP MB LPP HCTP4 DKFZp761E1322 PMC3245506__F5 Network of differentially expressed genes in HMGA1 transgenics at 12 months (parametric approach) HEL164 UBE3A SMG1 EEF1E1 MSH3 FEN1 LIMK2 UBQLN1 NEK2 IRAK1 PER3 MDM4 CCNG1 HMGA1 CCNG2 PAK1 PRP4K SPAG5 MB PMC7842749__F8 Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease AQP4 HEL70 HTT PMC11561128__F8 GLS2-mediated glutaminolysis accelerated AS process by encouraging endothelial mitochondrial dysfunction and pyroptosis via SIRT3/FOXO3a axis SIRT3 GSDMD NLRP3 GLS2 PMC9553361__F2 Molecular Mechanisms of Defective Copper Metabolism in Diabetic Cardiomyopathy DLAT GC ATP7A PMC5356597__F3 GADD45B, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens DBF4 RAD21 CDK7 PCNA E2F4 STAG1 CDC45 CD14 CDK2 MDM2 MYT1 SKP2 PMC2923430__F9 Immune Response MASP1 C6 C7 HEL-S-62p C2 C9 PMC4758681__F6 The mechanism of Wnt-mediated suppression of osteoclast differentiation APC LRP5 LRP6 NFATC1 CTNNB1 PMC7367812__F2 Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions TMPRSS2 ECSIT TBK1 IFITM2 TRADD STAT2 IRF9 IRF3 IRF7 TRAF3 CXCL10 TRAF6 MYD88 ISG20 IFNK TRIM25 TLR3 CASP3 TLR8 TLR7 ISG15 TRAF2 ACE2 CASP10 PMC3226315__F1 Recent focus in JMML has concentrated on using the information gained from knowledge of these molecular defects in order to design targeted drug therapy NF1 GRB2 PMC5727313__F1 The B‐catenin‐dependent Wnt signalling cascade in the ON‐state PAF1 APC LRP5 LRP6 PCK1 CTNNB1 PMC7022273__F2 : Ca2+-calpain, cAMP- exchange protein directly activated by cAMP (Epac)- phosphoinositide-specific phospholipase CE (PLCE)-inositol phosphate 3 (IP3), and inositol signaling pathways of autophagy regulation HMGB1 JUN ATG12 FOXO1 FOXO3A TFEB ATG14 BNIP3 RAP2B ATG5 FOS PMC8551632__F5 Cyclin-Dependent Kinase 5 Regulatory Subunit Associated Protein 3: Potential Functions and Implications for Development and Disease RELA VEGFA CTNNB1 PMC7022273__F3 Binding of tumor necrosis factor A (TNFA) with TNF receptor activates the receptor, which recruits TNFR1-associated death domain protein (TRADD) RIPK3 ATG3 TRADD MLKL RIPK1 CYLD TRAF2 FADD PMC479700__F1 IFN-Gamma-inducible CIITA transcription from the type IV promoter is mediated by the Janus Kinase-1/Signal Transducers and Activators of Transcription-1 (JAK-1/STAT-1) signaling pathway STAT1 MHC2TA USF1 PMC7616045__F1 Serine synthesis pathway, folate cycle and methionine cycle PHGDH DHFR PSAT1 PSPH PMC7080263__F5 RNA-seq transcriptomic analysis reveals genes mediating salt tolerance through rapid triggering of ion transporters in a mutant barley ERF TPK1 SOS2 PMC8651982__F1 T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development HDAC1 APC GSK3B LRP5 LRP6 BARHL2 PMC7864737__F4 Target genes in the mTOR signaling pathway RHEB FLCN PTEN MTOR DEPTOR EIF4E PMC3654985__F4 Peritumoral (P) activated hepatic stellate cells (HSCs) and intratumoral myofibroblasts (T) LPL UBC PERP ATM PTEN PLTP CPT2 SRA1 PMC7998496__F1 Mode of curcumin actions as anti-cancer agent on the key molecular targets in GBM BAX SHH SMO MDM2 PMC1774677__F1 Diagrammatic indication of the cytokines, transcription factors, and signalling molecules which polarise virgin CD4 cells into T helper cell type I cells STAT3 STAT1 STAT4 PMC8745665__F2 Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration IGF2R BAD INSR FOXO1 GSK3B IGF2 M6PR IRS1 CTNNB1 PMC4449428__F1 TGFB signaling in gliomagenesis and its targeting LIF SOX2 SMAD4 PTEN IGFBP7 CYLD ID1 SOX4 ID3 TGFBR1 PMC5356913__F2 Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation SYK BTK RHO PMC2994209__F1 HER receptors and their ligands NRG2 EGF NRG1 HBEGF EREG TGFA EGFR NRG3 AREG NRG4 PMC2923187__F8 Hybrid Models Identified a 12-Gene Signature for Lung Cancer Prognosis and Chemoresponse Prediction PMS2 EGFR HEL-S-28 STK24 SMPD1 CCL5 ATP6V0D1 TNF INS KRAS E2F5 RANBP2 IFNG ANP32B IGF1 ELAVL1 E2F4 PDPK1 APP PKLR IL1B PMC5587989__F2 YAP is regulated by various factors during hepatocarcinogenesis in addition to the members of the Hippo signaling pathway MAPK14 MCAM BTRC TRIB2 PMC5587989__F1 Hippo/YAP signaling pathway maintains the balance between cell proliferation and apoptosis LATS1 LATS2 PMC8844466__F6 In silico Analysis of SARS-CoV-2 ORF8-Binding Proteins Reveals the Involvement of ORF8 in Acquired-Immune and Innate-Immune Systems TH TLR3 IRF3 TRAF3 PMC8957335__F2 Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma SUFU SMO CTNNB1 GLI3 PMC5393956__F2 mTORC1 and mTORC2 in cancer and the tumor microenvironment RHEB TSC2 TSC1 PTEN PMC8699317__F5 CD44: A Multifunctional Mediator of Cancer Progression CD44 RAB7A HAS2 KRAS TWIST1 FGFR2 PMC3358519__F1 Schematic diagram of the cholinergic anti-inflammatory pathway (CAP) ACHE STAT3 PMC3924851__F2 New Function of Type I IFN: Induction of Autophagy RPS6 EIF4B ATG16L1 STAT2 IRF9 IRS1 EIF4E ATG10 IFNK STAT1 ATG3 ATG12 IFNAR2 IFNAR1 JAK1 PMC6977532__F2 Sepsis on AHR and inflammatory factors STAT3 TLR4 AHR SRC IL1B PMC3268941__F1 Canonical Wnt/Beta-catenin and non-canonical Wnt signaling pathways ROCK2 ROR2 LRP5 LRP6 ARHA RAC1 CTNNB1 PMC5148031__F5 Developmental Stage, Muscle and Genetic Type Modify Muscle Transcriptome in Pigs: Effects on Gene Expression and Regulatory Factors Involved in Growth and Metabolism LPL KLF3 NFATC4 LEP BSCL2 TXNIP SETDB1 HIF1A FABP4 XBP1 CTNNB1 FBXW7 CTBP2 SOX9 FOXC2 RBP1 PLIN1 MNAT1 CTBP1 BMP2 LPIN1 MSC EGR2 ATG5 PMC5464927__F4 Regulation of Beta-catenin activity and function in cancer: therapeutic opportunities BCL9 TNK2 TNK1 APC GSK3B LRP5 LRP6 LEF1 AXIN2 CTNNB1 PMC2831839__F9 A proposed mechanism of MNTX synergistic effects with temsirolimus on inhibition of VEGF-induced angiogenic events RICTOR PI3 MTOR SRC PMC8044931__F2 Molecular mechanisms by which estrogens mediate chemoresistance ATR BRCA1 EGFR BCL2 ATM SSB PMC5090056__F1 Models of Hippo pathway in fly and mammals LATS1 MOB1A MOBKL1A LATS2 PATJ CRB3 AMOT NF2 PMC8702415__F3 Bioactive glasses incorporating less-common ions to improve biological and physical properties GSK3B CTNNB1 PMC9094703__F1 Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders NPAS2 CRY1 HEL70 MAOA RORA PMC8234974__F3 Engineered EV-Mimetic Nanoparticles as Therapeutic Delivery Vehicles for High-Grade Serous Ovarian Cancer EGF SIRPA CD47 PMC7842075__F7 Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma CTRL MTCH2 MMP9 PMC9120866__F5 Dual-Role Ubiquitination Regulation Shuttling the Entire Life Cycle of the Flaviviridae SPSB2 TRIM14 TRIM69 UBE2S ISG15 PMC4160261__F1 Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease LAMP2 ULK1 MTOR PMC7232714__F8 DIFFERENTIAL ROLES AND ACTIVATION OF MAMMALIAN TARGET OF RAPAMYCIN COMPLEXES 1 AND 2 DURING CELL MIGRATION IN PROSTATE CANCER CELLS EGF RICTOR PAH RAC1 PMC8788756__F3 Physiology of Astroglial Excitability TRPA1 INSR TRPC1 PMC7911475__F2 Mechanism through which flavonoids induce cancer cell autophagy STAT3 GC PMC9303584__F2 Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics STAT3 STAT1 BAD CDK6 NF1 EGFR BRAF CDK2 PTEN MDM2 CDK4 PMC7158350__F9 Roles of DEAD/DEAH box helicases in innate immune signaling pathways MAVS TLR9 IRF3 IRF7 TRIM21 MYD88 DDX24 BTK TLR3 DHX36 DHX15 DDX41 DDX46 FADD PMC7042114__F1 BNP plays critical roles in itch transmission HRH1 HTR1F ITCH KPG_011 TRPV1 MMP9 CXCL10 TRPM6 SST S1PR1 5HT1A CCL20 NPPB PMC9154101__F7 HbF induction by SAL ATF4 ATF2 EIF2A CREB1 PMC5978700__F2 Role of RAS enzymes in the EGFR signaling pathway EGF TGFA EGFR PMC9415417__F2 Calcimimetics in Treating Bone and Mineral Disorders Related to Chronic Kidney Disease WNT10B CASR BAX NFATC1 MTOR PMC6162436__F1 Hippo pathway upstream modulation RASSF6 RASSF2 RASSF1 RASSF4 TEAD4 LATS1 FRMD6 LATS2 TEAD2 TEAD3 WWC2 AJUBA NF2 PMC6162436__F3 Repurposing of drugs on YAP (Yes-1 associated protein)-TEAD (transcriptional enhanced associate domain) system through cross-talking pathways LATS1 LATS2 AXL GSK3B AMOTL2 AMOTL1 AJUBA RHO GRB2 IRS1 CTNNB1 PMC3496019__F1 Cancer Stem Cells KIF3A BOC SUFU PTCH1 DHH SHH IHH SMO MYC GLI3 PMC6981417__F7 Differential ganglioside metabolism pathways between MDA-MB-231 GD3S+ clone #4 and MDA-MB-231 breast cancer cells CAS1 SLC33A1 B4GALNT1 ST8SIA1 PMC6981417__F6 Differential ganglioside metabolism pathways between Hs 578T and MDA-MB-231 breast cancer cells CAS1 SLC33A1 B4GALNT1 ST8SIA1 PMC8304479__F6 Polyphenol-Enriched Blueberry Preparation Controls Breast Cancer Stem Cells by Targeting FOXO1 and miR-145 SOCS1 STAT3 NRAS MTOR PMC8469825__F1 Autophagy Dysregulation in Diabetic Kidney Disease: From Pathophysiology to Pharmacological Interventions ATG12 ULK1 VMP1 MTOR STX17 ATG5 PMC3496019__F2 Regulation of CSCs by inflammatory cytokine networks BMI1 STAT3 CXCR1 RELA PTEN IL8RB CCND1 PMC8764452__F2 Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis CD81 CD9 SHH MMP2 PMC6626338__F7 LUCAT1 and Wnt/beta-catenin signaling in breast cancer TCF7L2 APC LRP5 LRP6 CTNNB1 PMC8750814__F2 Elucidating T Cell and B Cell Responses to SARS-CoV-2 in Humans: Gaining Insights into Protective Immunity and Immunopathology CD40 IFNG CD27 GC TLR8 CXCR5 TLR7 BCL6 PMC2637783__F1 Toll-like receptor (TLR) signaling TBK1 MAL TLR9 IRAK1 TLR5 IRF3 TNF MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC8082422__F2 Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets FGF8A FRS2 FGFR4 GSK3B GRB2 CTNNB1 PMC4987369__F1 Schematic representation of a mechanism of action for cannabinoid based multi-target drugs COX2 TRPV1 FAAH PMC11726942__S1 Amantadine and its therapeutic role in spinal cord injury CD81 HEXB LY86 CX3CR1 CFH CSF1R IL1B SPP1 PMC3149084__F2 Single-run analysis of the yeast proteome by LC MS/MS HEL60 ACO2 ENO2 PGM3 LAT PGM2 FBP1 HEL-S-32 HEL-S-26 CIT PMC3527239__F2 Metabolic pathways of TAG synthesis and degradation and their subcellular localization (adapted from and ) TES FEN1 CDS1 GPT2 HEL-S-5 FAT1 INS POT1 PMC10519146__F10 Intracellular innate immune response to avian influenza TBK1 IFITM2 MAVS IRF3 IRF7 RSAD2 TRAF3 TRAF6 MYD88 IFIT5 IFNG TLR3 OASL TLR7 PMC3527239__F5 Compartmentalization of the Beta-oxidation pathway and the glyoxylate cycle HEL60 MDH2 POT1 PMC9020428__F2 Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine BAX BAD PTEN EIF2A PMC3245119__F2 Non-canonical Wnt-signaling pathway GNG2 GNAS RYR2 PLN MLEC MAP3K7IP1 PTEN PMC1431720__F7 Cytokine release in RAW 264.7 macrophages IFNG STAT1 TLR1 TLR4 TLR7 PMC4914160__F10 Model depicting autophagy receptor recruitment to depolarized mitochondria over time TBK1 PINK1 OPTN PMC8258107__F1 Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation TRPM5 DPP4 TRPV1 PLCB2 CALHM3 CALHM1 PMC7483885__F2 Pathway map for the production of terpenoid compounds IPP MAL CIT PMC4994463__F4 “Inhibition of MMPs” signaling pathway at 1, 4, 7, and 14 days after nerve crush injury.Differentially expressed genes are shown in red (up-regulated) and green (downregulated) TFPI2 TIMP3 RECK TIMP4 AIMP2 MMP2 A2M PMC3398465__F4 Systems analysis of salivary gland development and disease EGF CS HBEGF SEMA3C SEMA3A PLXNA1 BMP4 SHH SMO CTNNA1 EDAR SPRY1 GLI3 PMC6364034__F9 Working model illustrating that KSHV hijacks the citrulline-NO cycle to promote KSHV-induced cell proliferation and cellular transformation ASS1 ASL PMC7905684__F1 Novel targeted therapies for Parkinson’s disease GLP1R GDNF LRRK2 SI HEL70 PMC3929010__F12 Reactive Oxygen Species in Inflammation and Tissue Injury BAX CASP9 JUN JUND FAS TRADD CASP3 TRAF2 FADD PMC2970638__F8 Up-regulation of Paxillin and Focal Adhesion Signaling follows Dystroglycan Complex deletions and promotes a Hypertensive State of Differentiation MAX FAS FH MAPKAPK2 CS ARHA PMC5037279__F6 Proposed model for how mTORC1 activity controls pro-IL-1B expression TSC1 TLR4 TRAF6 IL1B MYD88 PMC3929010__F10 Reactive Oxygen Species in Inflammation and Tissue Injury VCAM1 CXCL8 PMC8332866__F9 Epimedokoreanin C, a prenylated flavonoid isolated from Epimedium koreanum, induces non-apoptotic cell death with the characteristics of methuosis in lung cancer cells ARF6 EEA1 PIKFYVE PMC85825__F9 Model illustrating the relative positioning of aPKC within the NGF signaling cascades for survival and differentiation NGF NGFR SRC PMC10705325__F13 Study on the Effect of Oleic Acid-Induced Lipogenic Differentiation of Skeletal Muscle Satellite Cells in Yanbian Cattle and Related Mechanisms LPL UBC AQP7 UCP1 HEL-S-28 PLTP PMC7976587__F3 Possible feedback loop between PTX3 and TNFA via NFKB signaling pathway in inflammation PTX3 CXCL1 IL1B PMC8513144__F1 Brain as an insulin-sensitive metabolic organ RICTOR IGF1 MTOR NRF1 IRS1 PMC11576080__F2 Therapeutic interventions that specifically target signaling pathways in B-cell lymphoma CD79B SYK CD79A BTK BCR PTEN LYN PMC6518034__F2 Schematic drawing of the details of the signaling pathways of five major cardiomyopathies BAX BAD FAS APC PTEN PMC11576080__F1 Major B-cell signaling pathways and their crosstalk CD40 RPS6 SYK CASP9 CD79B BAD CD79A CARD11 RELB GIP PTEN TRAF3 PDK2 MYD88 TSC2 BTK BCR RELA MDM2 PMC8412938__F10 Summary model ADRB3 CXCL12 C1D RETN CFD MGLL PMC6438043__F5 Pathway representing T cell signaling CD3D SYK CD80 JUN LCP2 NFATC2 PTPRC BLNK VAV1 IL2RB BTK PLCG1 BCR IL2 CAMK4 GRB2 CD8A LCK PMC3746496__F2 PKM2 activity is controlled by a tight regulatory network at the transcriptional, proteomic and metabolic level STAT3 GLS EGFR HIF1A CCND1 CTNNB1 PMC8841346__F1 Beginner’s Guide to O-GlcNAc: From Nutrient Sensitive Pathway Regulation to Its Impact on the Immune System OGA OGT NEUROD1 PMC5467995__F1 Major intracellular pathways leading to Type-I-IFN production STAT1 CGAS MAVS TLR3 STAT2 IFNAR2 IFNAR1 NOD2 IRF3 IRF7 JAK1 PMC8841346__F2 Beginner’s Guide to O-GlcNAc: From Nutrient Sensitive Pathway Regulation to Its Impact on the Immune System OGA OGT IRS1 PMC3634825__F2 Transcriptome Analysis of Skin Photoaging in Chinese Females Reveals the Involvement of Skin Homeostasis and Metabolic Changes TGFB1 INHBC SMAD2 THBS3 PPP2CA NODAL MYC TGFBR1 INHBA INHBE E2F4 LEFTY1 FST ROCK1 NOG ID4 LEFTY2 AMH DCN MAPK1 BMPR2 ACVR2B THBS1 ID2 ARHA TNF RBL1 RBX1 SMURF1 BMP2 SKP1 EP300 AMHR2 SMURF2 PMC2686679__F12 Signaling pathway leading to Egr-1 biosynthesis in thrombin or carbachol-stimulated 39M1-81 cells EGF REST EGR1 PMC3634825__F3 Transcriptome Analysis of Skin Photoaging in Chinese Females Reveals the Involvement of Skin Homeostasis and Metabolic Changes EHHADH HMGCL ACADSB PCCA DBT PCCB ACADM MCEE ABAT ACAT1 ALDH2 HADHB OXCT2 MCCC2 BCAT2 MCCC1 OXCT1 ECHS1 AOX1 ACADS HSD17B10 ALDH3A2 HMGCS1 IVD ACAT2 ALDH7A1 ALDH9A1 BCAT1 DLD ACAD8 PMC10865100__F1 Classical model of G1–S transition regulated by cyclins and cyclin-dependent kinases (CDK) CDC2 STAT3 TGFBI CDK6 CDK2 MTOR CDK4 PMC3025359__F1 Mincle- and Dectin-1-mediated signalling in response to mycobacteria SYK APC SRC TRAF6 IRAK4 CARD9 MYD88 PMC11761900__F1 JAK/STAT signaling pathway and the selective inhibition of JAK1 by upadacitinib in inflammatory bowel disease JAK3 JAK1 TYK2 PMC3719407__F4 Functional link between the BMP system and GnRH-induced FSH transcription BMP6 SMAD1 DKFZp781O1323 SMAD6 BMP7 FSHB PMC5442177__F2 Transcriptional regulation of hepatic mIndy mRNA levels in model organisms and humans STAT3 AHR PMC3679268__F7 GSK-3A Promotes Oncogenic KRAS Function in Pancreatic Cancer via TAK1-TAB Stabilization and Regulation of Non-Canonical NFKB MAP3K7IP1 GSK3A RELB PMC7385848__F1 Bile acid metabolism pathway.Two major pathways are involved in bile acid synthesis AKR1D1 CYP8B1 CYP7A1 HSD3B7 CYP27A1 AKR1C4 PMC3499662__F1 Cell-signaling pathways from the UPR to autophagy and ER stress-induced apoptosis BAX AGA XBP1 TRAF2 PMC6404485__F9 Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage CD36 APC CTNNB1 PMC2815088__F5 Hexosamine Signaling Pathway: O-GlcNAc cycling in feast or famine RHEB OGA OGT EEF2K TSC2 GSK3B EEF2 PTEN MTOR SIRT1 IRS1 PMC2815088__F4 The Hexosamine Signaling Pathway IGF1 PTEN PDK2 IRS1 PMC6258484__F5 Pathway network and MAPK signaling MAX ECSIT FAS SLA CCK CD14 ATF2 TNF DAO FLNA MEF2C NLK GRB2 PMC2719943__F1 Reduced levels of neurotransmitter-degrading enzyme PRCP promote obesity PRCP POMC MC4R NPY AgRP PMC6952937__F1 Two different NFKB signaling pathways LTB RELB TNF IL1B PMC3075579__F4 The PI3K pathway in TLR-signaling RHEB MAL IRF3 PTEN TRAF6 IL1B MYD88 PMC2815088__F6 Hexosamine Signaling Pathway: O-GlcNAc cycling in feast or famine OGA OGT POLI MTOR PMC6337659__F2 Proposed mechanisms of polycystins implication in CRC MTOR SRC CTNNB1 PMC5514100__F15 HOXA11-AS co-expressed genes were significantly overrepresented in the non-small cell lung cancer pathway, revealed by KEGG pathway analysis– (http://www.kegg.jp/kegg/kegg1.html) CASP9 RARA EGFR ERBB2 FHIT DAO PMC4512023__F4 PTGS pathway deregulation during colorectal tumorigenesis COX1 COX2 PMC9301135__F1 Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease RHEB TSC2 TSC1 KEAP1 TAB3 IRAK1 HEL-S-28 TRAF6 DEPTOR RAC1 IRAK4 SIRT1 PMC8388841__F1 Opposite Roles for ZEB1 and TMEJ in the Regulation of Breast Cancer Genome Stability RAD51 ATM PMC6565612__F1 The roles of the cAMP-PKA and cGMP-PKG pathway in DRG neuron hyperexcitability after peripheral injury or injury- related stress including chronic compression of DRG (CCD) and acute dissociation of DRG (ADD) TRPA1 GC PIEZO2 TRPV1 PMC9376094__F9 TDP-43 suppressing apoptosis by modulating ABHD2 in HCC TG ABHD2 PMC6136178__F8 DACT2 and the Beta-catenin/Cdc25c pathway DACT2 CCNB1 LEF1 CTNNB1 PMC5509646__F6 The regulatory network of lipid accumulation with significant characteristics CD36 FABP4 ADFP RRAS2 PMC5167032__F2 Dysregulated Toll‐like receptor signalling associated with advanced age TLR1 TLR4 MAL IRAK1 IRAK2 IL6 TRAF6 IRAK4 MYD88 PMC9218868__F2 Multifunctional Roles of MicroRNAs in Schistosomiasis NR1i1 SEMA4D SMAD2 SMAD4 PMC8952333__F6 Advances in HIV-1 Assembly GBP5 IQGAP1 FURIN PMC2806029__F2 Ammonia detoxification pathway and mitochondrial sirtuins ASL SIRT4 OTC ARG1 PMC8534485__F1 Porphyrias in the Age of Targeted Therapies HMBS CPOX AIP ALAS1 ALAS2 UROD UROS PMC4479729__F1 The synthesis of glycoconjugates from glucose through the hexosamine biosynthetic pathway (HBP) OGA TH OGT GAL PMC10278599__F2 CAR T cell cytolytic mechanisms and paracrine effects IFNG FAS TNF PMC7697636__F1 Classical degradative autophagy (macroautophagy) RHEB ATG10 ATG3 ATG16L1 ATG12 ATG5 PMC10308135__F4 Mechanistic insight into lysyl oxidase in vascular remodeling and angiogenesis LOX SPP1 PMC11889768__F11 Potential pathways by which abscisic acid (ABA) influences 2-acetyl-1-pyrroline (2-AP) biosynthesis in aromatic rice PRODH DAO PMC7286881__F4 Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics TF PPARG LTA FGF21 HLA-DRB1 F7 NR1C2 HIF1A CCL2 HMOX1 IFNG PLAT F2 IL18 MMP3 FLT1 NPY KDR KNG1 ACE2 LPL VWF SERPINC1 THBS1 LEPR PTGS2 MMP9 VEGFA TNF HEL-S-78p FGF2 AGTR2 HMGCR NPPA FABP2 ADRB2 RS1 LIPE PLTP FGA PMC5758508__F8 Rationale for the problematic role of B2 adrenergic agonists in clinical trials ADRBK1 PC CFTR CTNNB1 PMC7991574__F6 The used inhibitors and the signal transduction pathways involved in BDNF and C3 effects on SGN HEL-S-62p ARHA BDNF PMC8657675__F4 Intermittent Hypoxia on Cytokine Expression Involved in Insulin Resistance RETN CCL2 PMC5083752__F3 Hedgehog signaling activation in TNBC: interplay of ligand‐dependent and ligand‐independent mechanisms BMI1 FOXC1 SHH NRP2 IHH SMO HIF1A PMC10528641__F2 Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes LATS1 LATS2 PTEN MTOR PMC4472151__F5 Lineage specific differentiation for MSCs in an exquisitely coordinated process with critical regulators and indicators are shown EGF APC NFATC1 TRAF6 SKI DAO CTNNB1 SOST SHH SMO PTH HOXC8 MSX2 PMC5083752__F1 Hedgehog signaling cascade HHIP BOC SUFU GSK3B DHH SHH IHH SMO PMC4472151__F4 BMP signaling and its regulation TF APC TFAP2A ATF2 SMURF2 DLX5 TRAF6 SKI ID1 MSX2 PMC2989879__F3 The RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system CITED2 BNIP3 NRF1 PMC2989879__F2 The RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system CITED2 COX2 ATM PTEN CTNNB1 PMC6368966__F1 Proposed divergent role of Notch signaling in endothelial and smooth muscle cells BMPR2 HEL-S-28 NOTCH3 NOTCH1 PMC6170333__F1 The synthetic pathway for development of the hyperbranched polymer based theranostic nanomedicine incorporating either A8 (HBP/A8/DOX) or A13 (HBP/A13/DOX) BOC PMC4885935__F1 Roles of sclerostin, Lrp4 and Wls in Wnt/Beta-catenin signals in osteoblasts LRP4 APC LRP5 LRP6 CTNNB1 PMC7558374__F3 Known functions of FMDV non-structural proteins on immune escape TBK1 STAT2 IRF9 TANK IRF3 IRF7 TRAF3 TRAF6 ADNP EIF4E STAT1 ATG12 NOD2 DCTN3 TRAF2 ELF3 PMC7558374__F2 Known functions of FMDV structural proteins on immune escape IFNG TBK1 STAT1 STAT2 RPSA IRF9 TANK IRF3 TRAF3 JAK1 TRAF2 PMC11033278__F8 PPI interaction network TCIRG1 GATA2 ACOT13 NDUFA12 NDUFV3 UQCR10 SCO1 HEL-S-25 KCNN4 UQCRQ NDUFS3 ATP6AP2 COXFA4 SLC25A4 SLC25A24 COXFA4L3 SLC16A7 OPA3 NME4 PYURF TSFM NDUFB4 NDUFA3 PC NDUFB3 ZFPM1 SCO2 MTHFS NDUFB10 FLI1 PIGA PMC5824531__F1 Signaling pathways linked to Insulin/IGF signaling in PDAC BAD FOXO1 BCL2 PTEN IGF1R TBC1D4 IGF2 PMC10889522__F6 Schematic illustration of YTHDF2 mediating the action of BDNF stimulating the proliferation of porcine follicle granulosa cells PCNA YTHDF2 BDNF CDK4 PMC4411413__F2 Differential expression of genes involved in MAPK signaling pathway in mouse ovaries MAX DUSP10 CSA2 EGF FAS MAP3K12 BRAF PPP3CC FLNA PRKCH AK2 HEPH NRAS GCK ECSIT JUN CASP2 SET MAP3K7IP1 PAK1 RAP1A TMEM37 GRB2 BDNF GADD45A PMC8748746__F2 DFT calculation of biosynthetic pathway of vaticahainol A and B CPD PMC5640934__F1 TGFB superfamily signaling and its involvement in decidualization BMPR2 SMAD9 ACVR2B SMAD1 DKFZp781O1323 BMPR1A SMAD2 SMAD4 TGFBR1 TGFBR2 ACVR1B ACVR1 FST BMP2 ACVR1C AMHR2 ACVRL1 PMC1482580__F4 EDA signaling in hair follicle development LTB DKK4 SOSTDC1 DKK1 RELB SHH EDARADD EDAR PMC8786487__F3 Pharmacological Effects and Underlying Mechanisms of Licorice-Derived Flavonoids JUN KEAP1 TLR4 IL1B MYD88 PMC11395144__F3 Application of nanotechnology in MS and KOA treatment targeting TRPA1 inhibition GFAP CAMKK2 TRPA1 SIRT1 SLN PMC11395144__F2 Application of nanotechnology in breast cancer and PMA treatment targeting TRPA1 inhibition TRPA1 RAMP1 MTOR PMC9630654__F1 Meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing CDC42 SSH1 ARHA RHO PMC7654410__F1 Neddylation inactivation by MLN4924 treatment or genetic deletion is involved in multiple regulatory responses within immune cells TH CCR5 CCR2 IL6 PMC7504917__F2 Endogenous production of H2S and cross-talk between H2S/RSS and ROS/RNS in bacteria NHS PMC5819906__F7 miRNA-gene network contains six miRNAs and their target genes, which are involved in the insulin signaling pathway PHKA1 PIK3CA SLC2A4 PIK3R3 HK2 AKT3 GSK3B BRAF PIK3R1 INPP5D KRAS PDPK1 MAPK10 PPARGC1A GRB2 PMC5819906__F6 Differentially expressed miRNA gene targets in the insulin signaling pathway RHEB TSC2 BAD FAS INSR FOXO1 MTOR INS EIF4E PMC6954688__F8 Activation of the NMRK2 path to NAD+ synthesis as an adaptive energy sparing mechanism in the failing heart NR1C1 NAMPT NMRK2 PMC9323376__F8 Unkeito Suppresses RANKL-Mediated Osteoclastogenesis via the Blimp1–Bcl6 and NFKB Signaling Pathways and Enhancing Osteoclast Apoptosis DCSTAMP CASP3 NFATC1 MMP9 PMC5349656__F1 Hh signaling pathway and RUSKI Hhat inhibitors SMO PMC5682227__F2 PID gene defects in the IFNG pathway CD40 GATA2 IFNGR1 IRF8 STAT1 IFNGR2 IKBKB NFKBIA STAT4 ISG15 JAK1 TYK2 CYBB IL12RB1 PMC4322943__F1 Phosphortlated Smad3 is stabilized by ERG in ERG-positive prostate cancer cells SMAD2 SMAD4 ERG PMC5975185__F1 Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes FIG4 TBK1 IRF3 PMC4180639__F7 Putative model of Ahnak-dependent activation of TGFB signaling SMAD2 AHNAK PMC7898466__F7 TLS pathways for replication through Tg and EdA lesions TG REV1 POLK POLE PMC8146344__F1 Substrate Stiffness and Stretch Regulate Profibrotic Mechanosignaling in Pulmonary Arterial Adventitial Fibroblasts LRP8 TIMP1 SMAD2 HIF1A MMP9 IL6 COL3A1 LATS1 ACTA2 LATS2 COL1A1 LOX PDE1A MMP2 PMC7898466__F1 TLS pathways for replication through UV lesions REV1 POLK POLG POLI POLE POLN PMC11786765__F7 MRNA expression of different signaling pathway genes SMAD2 SMAD4 WNT4 LEF1 PMC3820435__F3 Cell death signaling by the ER stress response/UPR BAX ATF4 EIF2A TRAF2 PMC7886236__F3 Insulin-like factor-1 (IGF-1) signaling and the multiple pathway axis IGF1 EGFR IGF1R IRS1 PMC3673972__F10 Antioxidant and Anti-Inflammatory Effects in RAW264.7 Macrophages of Malvidin, a Major Red Wine Polyphenol TBK1 TIRAP TLR4 GSK3B CD14 PTEN TRAF6 MYD88 PMC3037032__F4 The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes C6 KDM2A PMC5831137__F1 Dual-targeting Wnt and uPA Receptors Using Peptide Conjugated Ultra-small Nanoparticle Drug Carriers Inhibited Cancer Stem-Cell Phenotype in Chemo-Resistant Breast Cancer DKK1 APC GSK3B LRP5 LRP6 CTNNB1 PMC8945028__F2 Manipulation of Meiotic Recombination to Hasten Crop Improvement RAD51 MSH2 SPO11 DMC1 PMC9437549__F2 Microbial lectome versus host glycolipidome: How pathogens exploit glycosphingolipids to invade, dupe or kill B3GNT5 B4GALNT1 ST8SIA5 FUT2 FUT3 ST3GAL5 ST8SIA1 B4GALT5 B3GALT4 B3GALT5 A4GALT ST3GAL1 PMC9393754__F4 Hypoxia-inducible factor-1 alpha in multidrug-resistant breast cancer ATG5 CTNNB1 PMC9597307__F1 Venetoclax resistance and solutions CD40 STAT3 TH BAX BAD TLR9 PTEN IRF4 NOTCH2 KRAS ATF3 FOXM1 SMARCA4 PMC3408479__F8 Endoplasmic Reticulum Stress Stimulates p53 Expression through NFKB Activation ATF4 EIF2A TRAF2 PMC7298530__F2 Unique Energy-Saving Strategy during Hibernation Revealed by Multi-Omics Analysis in the Chinese Alligator RYR2 GAA TRH TSHR NCF4 CTSS DUT ARC MPO OMD NAGA TG CTNS PMC8353059__F2 Emerging Role of PD-1 in the Central Nervous System and Brain Diseases ZAP70 STAT1 CD80 BATF JAK3 MTOR JAK1 PMC8353059__F3 Emerging Role of PD-1 in the Central Nervous System and Brain Diseases STAT1 JAK3 JAK1 PMC8972902__F4 Clinical and translational values of spatial transcriptomics LPL APOE B2M TFF3 SPP1 TREM2 TFF2 TFF1 IGLL5 FTL TYROBP CRISP3 APOL1 CFTR NPY ERO1A CA9 PMEL C9orf72 PMC7294267__F1 Three mechanisms suggested for the effects of statins and ACEis/ARBs in preventing severe pulmonary disease in COVID-19 ANGPT1 FOXO1 ANGPT2 ACE2 MYD88 PMC3214144__F1 HCMV promotes GBM pathogenesis PDGFRA GSK3B MMP2 HIF1A FOXP3 MMP9 CCND1 PMC3998120__F4 Origins of Metastatic Traits CYTIP VCAM1 VEGFA SRC CXCR4 PMC3669032__F6 Canonical pathway analysis STAT3 MAPKAPK2 A2M TNF PMC11201634__F4 An illustration of the specific Wnt signaling pathway associated inhibitors that have been studied in preclinical and clinical trials for pediatric tumors PORCN APC LRP5 LRP6 CTNNB1 PMC11201634__F2 Wnt/Beta-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment APC GSK3B LRP5 LRP6 CTNNB1 PMC11201634__F1 Canonical Wnt signaling pathway APC LRP5 LRP6 CTNNB1 PMC6218864__F8 Simplified schematic of the effects of nephron-specific Jab1 deletion on the CUL3-KLHL3-WNK pathway WNK4 KLHL3 OSR1 PMC5705551__F1 Major in vivo approaches for tolerance induction and suppression of inhibitor formation in hemophilia CD80 BCR APC PDC FOXP3 MTOR PMC6878006__F6 Predicted localization of proteins and biosynthetic pathways in Synechocystis CYB MNT AMT F3 PC FES FDX1 PMC9709406__F6 Icotinib derivatives as tyrosine kinase inhibitors with anti-esophageal squamous carcinoma activity EGFR PTEN GRB2 MTOR PMC8774233__F2 Metastatic Progression of Osteosarcomas: A Review of Current Knowledge of Environmental versus Oncogenic Drivers MMP7 SOX9 COX2 MSLN RHO TWIST1 RBPJ PMC8214786__F7 Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect STAT3 AHR PMC4845199__F1 Possible model to explain the involvement of AATF in mTOR pathway DDIT4 DEPTOR AATF PMC10454115__F4 Mechanisms of Pi, Tf, Td, and Cr in AS TF TLR4 PMC4660682__F10 Differential proteins in acute phase signaling pathway in DN summarized in this and previous studies HEL-S-92n F8 CS FOS PMC7350255__F8 Representation of the KEGG protein process in endoplasmic reticulum pathway SVIP USE1 UBC SELL CASP12 SI HEL-S-11 ATF4 PMC8491019__F5 Regulatory network driving shoot lignification in rapidly growing bamboo MYB PRX ND2 PMC7593769__F7 Model of the C. acnes-induced intracellular signaling pathways TBK1 CGAS IRF3 MYD88 PMC3268503__F6 The Chl branch.The first step of the Chl branch is the insertion of Mg2+ into Proto IX POR COCH MGMT PMC7230378__F5 Cytoscape analysis considering TRAIL and miR-106b-5p in the apoptosis pathway CASP9 PIK3CA FAS CASP8 CASP2 PPP3R1 CYCS DAB2IP CTSS MAPK8 BCL2L11 IRAK4 ERN1 PDPK1 NRAS BCL2 RIPK1 ITPR2 TNFSF10 APAF1 PMC7947610__F5 Abnormal T cell Activation in GCA GCA PMC3577635__F2 Biochemical pathways leading to resistance to small-molecule epidermal growth factor receptor (EGFR)-targeting drugs such as gefitinib and erlotinib in non-small-cell lung cancer (NSCLC) PIK3CA AXL EGFR PMC8670088__F4 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis TBK1 MAVS ZC3H7A IRF3 IRF7 TRAF3 TRAF6 PMC6923932__F4 The molecular network of differentially expressed proteins in CAVD generated by Ingenuity Pathway Analysis HSP90AB1 ZNF74 ARMC5 MYO3B G2E3 ANXA2 HEL-S-269 DCLK2 CS IL6 GRK7 TNF MYLK4 TSSK2 INSRR KCTD8 ZNF215 C9 PSKH1 DKFZp686P11128 ALPK1 ZBED4 PMC8670088__F3 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis TBK1 MAVS IRF3 PMC9130481__F2 Multiple roles of endocytosis and autophagy in intracellular remodeling during oocyte-to-embryo transition APC RAB35 PMC5623854__F2 Non-apoptotic signaling pathway induced by CD95 PLCG1 CASP8 EGFR MTOR SRC PMC5623854__F1 CD95L is a chemoattractant for inflammatory T cells and triple-negative breast cancer (TNBC) cells MMP7 EGFR MMP3 ADAM10 PMC12157604__F6 Neuropathic pain pathways of Glutamatergic neurons under Mor vs Sal (A) and Mor+Pro vs Mor (B) conditions COX2 BDNF FOS PMC8835757__F6 Transcriptomic Profile of Canine DH82 Macrophages Infected by Leishmania infantum Promastigotes with Different Virulence Behavior SYK BAD CSF1 ITGA7 ITGA4 RBL2 PTEN CD19 FGF10 KITLG RAC1 EIF4E RHEB TSC2 RAD1 BRCA1 BCR CD37 MEI1 MDM2 PMC9271452__F3 Increased H3K27 trimethylation contributes to cone survival in a mouse model of cone dystrophy NDUFAF2 MRPL2 TIMM13 MTX1 MST065 CP PMC3556263__F1 Molecular pathways affected by CR and irradiation IGF1 IGF1R MTOR PMC5239434__F1 NADPH: new oxygen for the ROS theory of aging ME3 MTHFD1L PRX ME1 HEL-S-26 PMC8882093__F2 Helicobacter pylori and gastric cancer: a lysosomal protease perspective CXCL12 CCL3 MCL1 CXCL16 CCL4 CCL5 HP SRC CCL2 CXCL14 PMC5054901__F2 MiRNA function in the immune system ICOS PHLPP2 IRAK1 PTEN TRAF6 MYD88 PMC8004226__F6 Network of putative senolytic compounds with their biological targets ACHE JUN RAD51 PTPN6 HDAC2 PMC8895820__F2 Molecular environment and atypical function: What do we know about enzymes associated with Mucopolysaccharidoses? GALNS GATA3 PMC5529438__F8 Functional involvement of Hh signaling molecules in estrogen- mediated endometrial hyperplasia PCNA CTNNB1 PMC10520974__F3 Noncoding RNAs as an emerging resistance mechanism to immunotherapies in cancer: basic evidence and therapeutic implications TBK1 MAVS GPX4 GSK3B IRF3 MIOX HEL-75 PMC10520974__F4 Regulatory mechanisms of lncRNAs in cancer cell antigen presentation HEL-S-99n ERAP1 EZH2 TRIM71 TAP1 TAP2 HLA-B HLA-C HLA-A PMC7400772__F1 Immune evasion in EC IL10 CCL22 TAP1 PMC5343938__F3 Role of the RIG-1-like Receptors (RLRs) signaling pathway in antitumor immunity TBK1 MAVS CASP3 IRF3 PMC4211382__F3 Summary of intravascular/extravascular Hb/heme clearance and cellular/tissue distribution HP CD163 PMC5343938__F1 Toll-like receptors (TLRs) and TLR-mediated signaling pathway TIRAP TLR9 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR7 PMC8670088__F2 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis IFNG IL10 HEL-S-133P DPF3 IL6 HEL-S-30 IL1B PMC10520974__F7 Noncoding RNAs as an emerging resistance mechanism to immunotherapies in cancer: basic evidence and therapeutic implications TGFBR2 CSF1R TGFBR1 PMC8670088__F1 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis RHEB TSC2 TSC1 HEL-S-133P HEL-S-30 TUG1 PMC9408811__F4 Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa? IL17RC CSA2 IL1R1 TRAF6 MYD88 PMC6627901__F5 Model for the oncogenic activation of the EGFR signaling pathway and response to therapeutic EGFR-blockade in basal HNSCC EREG EGFR AREG PMC3261822__F3 IPA-based pathway analysis of differential expressed genes EAF1 CTSH PCOLCE MYC CPD ISG20 PDX1 BMP4 TTK ITPR2 ELANE VPS72 HBB HEL-S-2 ACOX1 TNFRSF12A CYP1B1 SATB1 ANGPTL4 ADAM9 SCARB1 NDRG4 ARF3 RUVBL2 MPP3 AKR1C4 PMC9408811__F2 Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa? NLRP3 TIRAP TLR4 IL1B MYD88 PMC3437546__F2 HIF target genes encode proteins involved in critical aspects of cancer progression HEL113 MMP14 TGFA TKTL2 EPO BNIP3 TERT CTSC LOX ANGPT1 SNAI1 MMP2 ZEB2 SNAI2 ADM ID2 HEL-S-133P PLAUR BNIP3L MMP9 ANGPT2 IGF2 TCF3 LOXL2 HEL-S-162eP EDN1 ENO1 PFKL HEL-S-87p PMC7968419__F1 Schematic presentation of possible cross-linkages between PCOS and HT FBN3 PTPN22 TRH CYP17A1 GNRHR FOXE1 CYP1B1 CTLA4 AMH FOXP3 FSHR LHCGR PMC5743625__F2 Epithelial PGR regulates multiple signaling pathways in the endometrium and transuduce signals via uterine epithelial-stormal inteactions GATA2 PTCH2 PGR EGFR PTCH1 BMP2 IHH WNT4 HAND2 PMC9281973__F1 Benefit–risk assessment of sonidegib and vismodegib in the treatment of locally advanced basal cell carcinoma SUFU PTCH1 SMO PMC2962956__F1 Toll-like receptor (TLR) signalling and inhibition by viral proteins TBK1 TAB3 MAL TLR9 IRAK1 IRF3 IRAK2 IRF7 TRAF3 IRAK4 MYD88 TLR1 TLR3 TLR7 PMC4039115__F5 Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another “double hit” lymphoma with very poor outcome? CDK6 BCL2 MYC CCND1 SIRT1 CDK4 PMC1769518__F1 Complement system consists of about 30 proteins that can be activated by 3 different cascades HEL-S-62p C2 C4A C4B_2 PMC4486472__F2 Neural Tube Defects GLDC MTHFD2 DHFR TYMS HEL-S-51e MTHFD1 AMT SHMT1 MTHFD1L MTHFD2L HEL-S-61p MTHFS MTR PMC2841246__F4 COX-2 inhibitors on apoptosis BAX CASP9 BAD CASP3 DIABLO CTNNB1 FADD PMC6001373__F12 Working model for the actions of HDAC1/2 in the regulation of nephrogenesis SALL1 HDAC1 WT1 LHX1 PAX2 SIX2 OSR1 HDAC2 HNF1A PMC5346747__F7 Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a GPC5 WNT3A APC MMP2 TWIST1 PMC2984599__F1 TP53 levels determine whether CDKN1A will orchestrate irreversible senescence or quiescence CDKN1A MTOR PMC12064795__F7 Schematic diagram for the mechanism of SYT7-ALDH1A3 axis mediated carcinogenesis in NPC STAT3 SYT7 ALDH1A3 PMC3235896__F2 Transdifferentiation of bone-marrow-derived mesenchymal stem cells (MSCs) into the multiple skin component cells HMGB1 PDGFRA CCR7 PMC11891113__F3 Expression levels of genes in phenylpropanoid biosynthesis, flavonoid biosynthesis, and galactose metabolism pathways under different drought treatments (CK, D9, D12) in C CAD GLS STS PMC7708490__F7 Proposed mechanistic scheme: MELK is critical for metastasis, mitotic progression, and programmed death of LUAD CDH2 CDC2 MMP7 PLK1 TWIST1 PMC8840921__F3 Aplysia Neurons as a Model of Alzheimer’s Disease: Shared Genes and Differential Expression CAMK4 CREB1 PMC8840921__F2 Aplysia Neurons as a Model of Alzheimer’s Disease: Shared Genes and Differential Expression RELA MYD88 BIRC3 PMC8166894__F3 Dendritic spine remodeling and plasticity under general anesthesia CDC42 ARHA RAC1 PMC3305973__F2 Sixteen genes associated with enzastaurin response were established by pathway analyses and prediction of drug response using an eight-gene signature MLPH NEDD4 INSR RPS27A PMC7022557__F1 PI3K-Akt signaling pathway BAX BCL2 MTOR INS PMC7527410__F1 SARS-CoV-2 viral entry to host cell pathway TMPRSS2 ADAM17 ACE2 PMC3924811__F10 Mechanosignaling in Bone Health, Trauma and Inflammation COL1A1 BMP2 RUNX2 CTNNB1 PMC2860235__F7 FunCoup subnetwork of candidate cancer gene RPA1 surrounded by functionally coupled known cancer genes CHFR PMS2 MUTYH SART3 PMC4182853__F1 The current understanding of p38D MAPK signalling and activation EEF2K PRKD1 EBP EEF2 ATF2 PMC5931255__F2 Hedgehog signaling pathway inhibitors SUFU SHH SMO PMC6128202__F1 Main signaling pathways affected in high-grade gliomas NF1 EGFR MTOR CDK4 PMC3248275__F7 Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice IGF1 IGF1R GRB2 CCND1 IRS1 PMC7780992__F1 Conceptual overview of potential mechanistic pathway of Aspergillus fumigatus recognition through pattern recognition receptors in dendritic cells to upregulate IL-10 production and to downregulate allergic hypersensitivity reactions MYD88 PMC6505497__F4 Sprouty2—a Novel Therapeutic Target in the Nervous System? RAF1 SIAH2 DYRK1A FRS2 GRB2 SRC PMC7754343__F1 Simplified schematic of the kynurenine pathway TDO2 ID2 HEL-S-90n IDO1 KYNU KMO NAMPT IDO2 PMC7336380__F1 TLR signaling and domain organization of TLR8 TIRAP TLR9 TLR5 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 TLR10 PMC3593900__F5 Schematic illustrating how TNF acts via the Wnt pathway leading to the development of the myofibroblast phenotype SMAD2 APC SMAD4 CTNNB1 PMC4243360__F1 Pathways of apoptosis FIG4 BAX BCL2 PMC6149803__F1 Mediating the death of dormant tumor cells STAT3 AHR SRC TYK2 PMC2515306__F1 Wnt signaling pathway and its inhibition by AB aggregates APC GSK3B LRP5 LRP6 TEF PMC5419474__F10 NCA-1 and NCA-2 Ion Channels Function Downstream of Gq and Rho To Regulate Locomotion in Caenorhabditis elegans TRIO UNC79 RHO PMC7594557__F11 Simplified overview of signaling from common types of DNA damage to the DDR and cell cycle checkpoint pathways CDC2 TOPBP1 ATR RAD50 ATRIP RAD51 H2AX BRCA2 SSB CDK6 MRE11A BRCA1 CDK2 ATM CDK4 PMC4572916__F1 Differential effects of Calmodulin on two key K-Ras4B effector pathways EGFR GIP OTP PMC4459530__F1 Unexpected Functions of NFKB during Germinal Center B-Cell Development: Implications for Lymphomagenesis CD40 LTBR BCR RELA RELB PMC9533094__F1 Minimal residual disease in EGFR-mutant non-small-cell lung cancer LATS1 LATS2 EGFR NF2 MTOR PMC8231866__F1 Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25 SIRT7 NMNAT1 SIRT4 SLC25A17 SIRT5 NMNAT2 NAMPT SIRT2 PARP1 SIRT3 SLC25A51 PARP3 PARP2 SIRT1 NMNAT3 SIRT6 PMC6591387__F2 Inflammasome regulatory network TBK1 PYCARD MAVS IFIH1 PTPRC SQSTM1 DHX58 SIRT2 POLR3A POP1 RIPK2 NLRP3 IL16 NOD2 CHUK HDAC6 EIF2AK2 IL1B MEFV LRRFIP2 IRF3 IRF7 NLRP1 PTPN22 FLI1 FOXO3A CARD18 TYK2 PMC8616422__F2 Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC3870072__F4 Subnetwork 1 and 5 of 6 networks in vehicle group PRMT1 ZAP70 HGF HOXB1 EBP PML SLC14A2 NEUROD6 CTNNB1 TRRAP RPS27 RPS3 BCR E2F3 SP3 SI DYRK3 FDPS SHC3 ABCC2 NKD1 JUN SIN3A FOSB SP1 USP34 MTA2 RPE65 RPS19 PRX BLNK HEL-S-28 SLC18A3 HRAS RGS18 PPP2R2A HOXA10 ARHGEF1 RPS25 HLA-B PMC3870072__F3 Two reversing pathways between the vehicle and baicalin groups CDC42 HRAS HEL-S-11 GRB2 SHE MEF2C OTP PMC8996985__F3 Transforming Growth Factor-Beta Orchestrates Tumour and Bystander Cells in B-Cell Non-Hodgkin Lymphoma SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC3870072__F5 Subnetworks 1, 2, and 4 of 9 networks in baicalin group RAN SP1 MAK PAX2 RELA FOS RET PMC4900586__F5 Molecular Portrait of Oral Tongue Squamous Cell Carcinoma Shown by Integrative Meta-Analysis of Expression Profiles with Validations PDPN TNC SNAI2 TGFBI IFI6 LAMC2 MMP10 PLAUR AIM2 PTK7 SCRN1 IFI35 MMP9 SPP1 FOXM1 INHBA PTHLH COL4A6 ITGA6 MMP3 MYO1B ISG15 PMC6780497__F4 Enriched extracellular matrix organization pathway in non-type subtype of bladder carcinoma cell lines LAMA5 PLOD1 FBN1 TIMP1 LAMC1 ITGB6 NCAM1 ITGB1 ITGA1 HEL-S-130P PLOD2 P4HA1 LAMA3 PMC7713309__F5 Ingenuity pathway analyses of the dendritic cell maturation pathway (A) and TREM-1 signaling pathway (B) at 72 h post-infection, and expression level of related genes (C) CD40 TREM1 LTA LTBR ZBTB12 CCL3 TNFRSF1A TREM2 HLA-DRA NLRP3 TYROBP TLR4 IL36RN NOD2 IL18 NOD1 MAPK12 TLR7 HLA-DMB FCGR2B CSF2 IL12A HLA-DQA1 FCGR1A IL1A IL6 HLA-DQB1 NLRC4 NLRP12 FCER1G NFKBIA IL23A PMC3013516__F8 The interaction between cPLA2A and TGFBsignaling pathways in hepatic cells TGFB1 SMAD2 PMC9010412__F6 SNORD1C was upregulated in CRC, which activated the canonical Wnt/Beta-catenin pathway and promoted the development of cancer stem cells SOX2 CTNNB1 PMC12250560__F4 Advances in Understanding Intestinal Homeostasis: Lessons from Inflammatory Bowel Disease and Monogenic Intestinal Disorder Pathogenesis RIPK2 ATG16L1 ITCH NOD2 PMC8526852__F1 Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants MOS tmp_locus_29 IRF3 PMC5971462__F9 Smooth muscle cells differentiation process TGFB1 ROCK2 SMAD4 PMC7346011__F8 The anti-inflammatory mechanism of P22077 TLR4 TRAF6 IL1B PMC2242658__F8 Wingless and integration site growth factor (WNT)-induced epidermal growth factor receptor (EGFR) transactivation EGFR WNT1 SRC SFRP1 CTNNB1 PMC12048993__F7 Macrophages with high expression of PD-1 inhibit their anti-tumor immune function STAT3 PMC6365644__F4 Differentially regulated metabolic fluxes and metabolites in gluconeogenesis (A), pentose phosphate pathway (B), TCA cycle (C), arginine biosynthesis pathways (D), and respiratory chain (E) under 2-mg/liter colistin treatment for 1 h MAL CP CIT PMC4063500__F2 Lithium’s autophagy regulation mechanism in various neuropsychiatric diseases GSK3B MTOR INS PMC3190105__F1 TLR-dependent and JAK/STAT-dependent signaling pathways in microglia IFNGR1 TIRAP TANK IRAK1 IRF3 IRF7 TRAF3 TRAF6 MYD88 STAT1 IFNGR2 TLR1 JAK1 PMC11631473__F2 Metabolic pathways for anabolism and catabolism of DAG in model yeast Saccharomyces cerevisiae PC FAT1 PMC5606034__F5 GPR and HDAC co-regulation network related to epithelium metabolism MGST3 POMT2 ND4L PIK3C2G MAOA COXFA4 MARS2 PLCG1 MAN2C1 SPHK2 ND6 GPR87 GPR155 ND2 ENPP2 PMC5606034__F4 GPR and HDAC co-regulation network related to epithelium growth PRKD3 GPR89B PLCG1 HDAC10 SPHK2 LAMTOR3 HDAC5 GPR155 NR1C2 MAP3K11 SIPA1L2 HDAC6 PMC11006178__F12 Proposed schematic model of METTL14 in TLR4-mediated innate immunity and promoting CSFV replication TLR4 METTL14 YTHDF2 PMC5226538__F3 ‘melanoma-enriched’ microRNA miR-4731-5p acts as a tumour suppressor DBF4 CDK6 CDK7 PCNA SMC3 SMAD4 CDK2 MDM2 MYT1 SKP2 CDK4 PMC4096053__F2 Many functions of promyelocytic leukemia nuclear bodies and PML as a negative regulator of the PI3-kinase/Akt/mTOR pathway RHEB TSC2 TSC1 PML PTEN MTOR PMC4494966__F4 Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells CLDN7 SPARC MRC2 NHLRC1 CARD8 ASAH2 FOXO4 QPCT CD151 MMP3 TFAP2C ELMOD3 HSPB8 HAND1 VOPP1 CALB2 TUBB4A ANXA9 TAOK2 SAMSN1 UMOD ERAF IRF8 TNLG2B GPER FGFR3 DKFZp686P11128 TSPAN8 PMC7504721__F1 Complement is activated by three canonical pathways known as the classical pathway (CP), lectin pathway (LP), or alternative pathway (AP) C6 SPR C7 HEL-S-62p C2 C1S C1R C9 CP PMC3810612__F6 Schematic diagrams of midsagittal sections through (A) the rainbow trout and (B) rat brains to summarize the contributions and interactions of the serotonergic and corticotropin-releasing factor (CRF) systems in the regulation of food intake CORT UCN ARC AgRP PMC9640632__F1 Probabilistic model checking of cancer metabolism MAL CIT PMC6601390__F3 Molecular characteristics of steroid hormone receptors in endometriotic tissue STAR PGR NR3A2 NR5A1 RERG TNF PMC5085631__F6 Model showing how decreased expression of SRSF2 affects apoptotic pathways in renal cancer cells BAX TNFRSF1B BCL2L2 TRADD TNFRSF9 CRADD TRAF2 FADD PMC9245023__F3 Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder NLRP3 IGF1 RHO MTOR IL1B PMC6104123__F1 TGFB induces CD103 expression in tumor-specific T cells and participates in integrin bidirectional signaling TGFBR2 HEL-S-28 TGFBR1 PMC9245023__F1 Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder TLR4 RIF1 TRAF6 MYD88 PMC10142983__F6 Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2 GLA FADS2 FADS1 PMC3060778__F4 Comparative and demographic analysis of orangutan genomes HEXB NEU3 ST8SIA6 A4GALT PMC8064692__F2 NRG/ErbB signaling and downstream signaling pathway EGF BAD TGFA ERBB4 NRG3 MTOR SHE NRG4 ERBB3 NRG2 HBEGF CBL ERBB2 GRB2 PMC8862564__F4 Germline specification from pluripotent stem cells SOX17 PRDM14 BMP4 OTX2 TFAP2C PMC5173082__F4 mTORC2/Akt pathway STAT3 EZH2 HIF1A IGF1R IRS1 PMC3838179__F11 Proposed model for the NOTCH-ROCK pathway and its biological significance ROCK1 RHO NOTCH1 PMC10976354__F2 KEGG enrichment analysis of the SGNI targets BAX CASP9 RARA JUN CAD CASP2 BCL2 ATM APP PTEN TNF PMC8914108__F1 New Insights Into Energy Substrate Utilization and Metabolic Remodeling in Cardiac Physiological Adaption TFAM PDK4 IGF1 PFKFB2 MTOR PMC4419619__F1 Modulation of Insulin-Like Growth Factor-1 Receptor and its Signaling Network for the Treatment of Cancer: Current Status and Future Perspectives IGF1 IGF1R IGF2 IRS1 PMC4375924__F5 Discordant and concordant gene expression in the PI3K-Akt-mTORC1 signaling cascade RHEB MLST8 TSC2 EIF4B TSC1 EIF3E PTEN MTOR DEPTOR EIF4E PMC6401644__F3 PIN1 acts at multiple levels of cooperating cellular pathways FBXW7 PIN1 CCND1 UNK NOTCH1 PMC10889501__F4 Postulated relationship between IL-1B/IL-1RA axis and autophagy signaling pathway in invasive bladder cancer TSC2 TSC1 MTOR PMC8625891__F1 Type of Fat in the Diet Influences Regulatory Aminopeptidases of the Renin-Angiotensin System and Stress in the Hypothalamic-Pituitary-Adrenal Axis in Adult Wistar Rats TH TRH NPY PMC9294202__F3 Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule DKK3 TNFAIP3 ITCH USP9X TRIM48 TRAF2 PPEF2 SLK PMC3886801__F1 STAT-3: A Molecular Hub for Signaling Pathways in Gliomas STAT3 EGF TTN SRC PMC3638038__F1 Pluripotent Stem Cells: Immune to the Immune system? CD83 CD80 APC CTLA4 FOXP3 PMC8198123__F2 Therapeutics Targeting the Core Apoptotic Machinery BAX FAS FADD PMC8515747__F9 Investigation of anti-osteoporosis mechanisms of Rehmanniae Radix Preparata based on network pharmacology and experimental verification POR RARA HEL-S-130P EBAG9 EGFR BCL2 GLA GRB2 SHE KRT19 PMC3474542__F2 Nongenomic and genomic estrogen signaling pathways TF HBEGF EGFR PMC3886801__F2 STAT-3: A Molecular Hub for Signaling Pathways in Gliomas STAT3 OSM TTN IL6 GRB2 PMC9407007__F2 Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review CXCL12 DLL4 CXCL16 IL6 CXCL10 CCL2 CXCR4 IL1B PMC8193943__F2 Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy TRAF4 USP15 KEAP1 RNF4 RNF11 RELA SMAD6 SMURF2 PMC8193943__F1 Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy CDK8 SMURF1 SMAD2 SMAD6 SMAD4 SMURF2 TRAF6 CDK9 PMC2936527__F1 Synthesizing and Salvaging NAD+: Lessons Learned from Chlamydomonas reinhardtii NAPRT KYNU KMO NAMPT AFMID PMC11997497__F8 Graphic model of dedifferentiation-immunosuppression loop formed by malignant cell and macrophage in ICCMalignant cells and macrophages in ICC are involved in a dedifferentiation-immunosuppression loop LILRB2 IL18 VEGFA LILRB1 YAP1 HMGB2 PMC8283745__F2 Four categories of regulatory mechanisms for nucleic acid-sensing Toll-like receptors UNC93B1 TASL SLC29A3 TLR9 TREML4 ECEL1 DNASE2 PLD4 PLD3 PMC6904658__F2 Probable immunoregulatory mechanisms mediated by gut microbiota as a consequence of faecal microbiota transplantation (FMT) in inflammatory bowel disease (IBD) IL10 AHR FOXP3 PMC10926624__F2 Molecular mechanisms of Trp metabolism in gastric cancer STAT3 GPX2 CGAS AHR IRF3 COL12A1 PMC10945197__F3 Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis CXCR3 CXCL12 NRP1 PTEN ARHA CXCR4 PMC10945197__F1 Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis CDC42 CXCL12 MSI1 FUT4 PTEN ARHA MTOR PMC7322951__F3 Accumulated lysosomal products on cellular and tissue homeostasis TIMP1 TLR4 PMC4422175__F1 Bile acid biosynthetic pathways AKR1D1 CYP8B1 HSD3B7 CYP46A1 CYP7B1 CYP27A1 AKR1C4 PMC4422175__F5 Farnesoid X receptor (FXR) regulates enterohepatic circulation of bile acids FGF8A ABCG8 ABCG5 NPC1L1 CYP7A1 FGFR4 PC PMC4422175__F8 Farnesoid X receptor (FXR) regulation of hepatic glucose and lipid metabolism in liver, adipocytes, and intestine FGF8A PCSK9 LPL TG FAS NR1C1 C2 CYP7A1 FGFR4 LDLR PMC8662531__F1 CGAS-STING signaling pathway TBK1 CGAS IRF3 TREX1 PMC4422175__F7 Bile acid-activated S1P2 signaling CYP7A1 EGFR GSK3B SRC IRS1 PMC9104626__F3 Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway TH BAX BAD MCU ATF1 SOCS3 BCL6 FADD PMC2147675__F1 Antimalarial therapy prevents Myc-induced lymphoma ATG12 HEL-S-162eP BNIP3 MYC PMC6232724__F9 Schematic diagram of icariin regulation upon PA-induced insulin resistance STAT3 TXNIP IRS1 PMC8047476__F1 Psoriatic arthritis is a multifactor disease STAT3 TLR4 IL23R MYD88 PMC5143759__F2 PIN1 dysregulation and targets in hepatocellular carcinoma MTOR PIN1 CCND1 NOTCH1 CTNNB1 PMC4167018__F7 Modulatory effects of low-dose H2O2 on the functions of pDCs CD40 CD83 CD80 PDC TLR9 IRF7 TLR7 TNF MYD88 PMC3079059__F1 Control of intracellular heme levels: Heme transporters and Heme oxygenases ABCB6 ABCB7 CPO FECH ABCB10 UROD PMC8226072__F1 Targeting Future Pandemics, a Case for De Novo Purine Synthesis and Basic Research PAICS CAD OMP UMPS HEL-S-70p DHODH ADSL PMC10815326__F7 Different patterns of inflammatory gene activation in cerebral cortex and cerebellum of Npc1−/− mice CXCL12 NPC1 TLR4 EBI3 CCL7 CXCL10 CXCL6 CKLF CXCL3 PMC7068213__F1 Graphical representation of the purine salvage pathway PNP GMPR GDA ADA PMC3689995__F7 Dual functions of Smad2 in the maintenance of hESC and mEpiSC pluripotency PGC CDX2 SMAD1 DKFZp781O1323 SMAD2 PMC5624830__F3 NOD1 and NOD2: beyond peptidoglycan sensing RIGI MAVS NOD2 IRF3 NOD1 XBP1 TRAF2 PMC10544979__F8 The MyD88 and TRIF signaling pathways and downstream responses by the protein-based adjuvants rSIP and FLH in APCs CD80 TLR4 APC MYD88 PMC3899946__F2 Radiation-Induced Bystander Response: Mechanism and Clinical Implications BRCA1 H2AX CDS1 CDK2 ATM MDC1 PMC5624830__F1 NOD1 and NOD2: beyond peptidoglycan sensing NOD2 NOD1 ARHA RAC1 PMC7915460__F2 EphA2 signaling in normal (A) and cancer (B) cells CDC42 CBL EPHA2 EGFR RHO SRC PMC7407580__F1 Involvement of the CCL5/CCR5 axis in cancer progression STAT3 CCL3 CCR5 MSC MMP2 CCL4 CCL5 MMP9 CCL8 PMC3711692__F5 Staufen-mediated mRNA decay STAU1 PMC3064905__F3A Genomic revelations of a mutualism: the pea aphid and its obligate bacterial symbiont NR1A2 THRA PMC9687456__F8 m6A Methylation Analysis Reveals Networks and Key Genes Underlying the Coarse and Fine Wool Traits in a Full-sib Merino Family MYB TSC2 GAL BAD RAF1 BCR RXRA RBL2 CD19 PTEN MDM2 IRS1 PMC8924581__F2 Peroxisome Proliferator-Activated Receptor Gamma and Atherosclerosis: Post-translational Modification and Selective Modulators SUMO1 ABCG1 CDK5 CDK7 CD36 PRDM16 ARG1 CDK9 ABCA1 SIRT1 SRA1 PMC5666810__F2 Thrombin cleaves the amino-terminal domain of PAR1 and triggers intracellular signaling ARHA MMP9 MTOR IL1B PMC9525297__F8 Schematic presentation of  process involved in the inhibitory effect of SC on TNBC metastasis EZH2 TNF PMC7022396__F3 Metabolic pathways involved in the de novo synthesis from sugars of floral esters by H PMC4346630__F10 RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL RIPK3 TRIR TRADD NLRP3 MLKL TLR4 RIPK1 TNF TRAF2 IL1B FADD MYD88 PMC4521753__F3 Identification of Oxygen-Responsive Transcripts in the Silage Inoculant Lactobacillus buchneri CD034 by RNA Sequencing RPE PGM3 AIDA PGM5 PMC9424684__F11 Z1456467176 alleviates gouty arthritis by allosterically modulating P2X7R to inhibit NLRP3 inflammasome activation GSDMD NLRP3 IL1B MYD88 PMC8857305__F4 Mechanical regulation of bone remodeling SMAD1 DKFZp781O1323 ROR2 GSK3B LRP5 SMAD4 LRP6 ARHA LATS1 POSTN LATS2 SOST BMP2 PMC8857305__F3 Mechanical regulation of bone remodeling GPR68 PIEZO1 SUFU SMO RHO SRC PTH1R PMC3539742__F2 Autophagy and apoptosis- what’s the connection? JUN FAS CASP8 CASP3 DAP FADD PMC2930807__F4 Gene pathway analysis LPL GNAI1 PYGM TNNC2 ABLIM3 GSK3B ACTN2 MC2R ACACA PCK1 ATP2A1 PYGL ACSL1 PDE3B NR1C1 FZD4 PRKAA2 CREBBP LIPE FLT1 PMC8071514__F4 Role of the acetylation pathway in TAp73 regulation LYST SIRT2 NOX4 PMC3403107__F8 The molecular pathway regulating Xenopus lung development BMP4 OSR2 SOX2 SFTPC OSR1 WNT2B PMC5602684__F1 Association of rs1801157 single nucleotide polymorphism of CXCL12 gene in breast cancer in Pakistan and in-silico expression analysis of CXCL12–CXCR4 associated biological regulatory network CXCL12 EGF BRCA1 EGFR PTEN MDM2 SRC CXCR4 PMC11572133__F7 LPAR3 regulates EPO induction by hypoxia LPA LPAR3 VHL PMC2820199__F4 Curcumin’s targets intracellular components implicated in cell proliferation signaling pathway in prostate cancer cells EGFR CDK2 MTOR PMC5270455__F4 Pathway derived from perturbation experiments RAF1 EGFR FGFR1 EDNRA HDAC5 CDK2 IGF1R PMC2820199__F3 Network of proteins, functional classes and cell processes modulated in prostate cancer cells after curcumin treatment BAX EGFR NFKBIA BCL2 PTEN PMC5685770__F2 Therapeutic potential of cell cycle targeting in multiple myeloma CDC2 CKS1B CDK6 CDC20 APC CDK2 CDK4 PMC4606174__F2 Crosstalk between signaling pathways that lead to colorectal cancer progression BAD EGFR APC LRP5 LRP6 PTEN GRB2 CTNNB1 PMC7502316__F3 Alterations of Spermatozoa Proteomic Profile in Men with Hodgkin's Disease Prior to Cancer Therapy TCP1 CCT7 CCT6A CCT4 ACR PRSS37 PMC2064427__F10 Schematic diagram illustrating the signaling mechanisms that control the bidirectional responses of the growth cone to BMP7 gradients LIMK1 BMP7 RHO PMC151138__F1 Signaling and transcriptional pathways of Th1 differentiation and the potential role of c-Rel STAT1 APC STAT4 PMC4911353__F5 Interaction and expression pattern of SDEGs involved in canonical interferon signaling pathway in Mtb-infected mouse lungs with or without CC-11050 treatment SOCS1 BAX IFITM2 STAT2 PSMB8 IRF9 IFITM1 IFIT3 TAP1 IFI35 IFNG STAT1 IFNAR2 PIAS1 OAS1 PMC8662531__F4 Aging and the cGAS-STING pathway TBK1 CGAS IRF3 TREX1 DNASE2 PMC3810296__F2 NLRP6 in Infection and Inflammation NLRP6 TLR4 RELA NOD2 AIM2 NOD1 IL1B MYD88 PMC9261412__F3 Recent Advances on Drug Development and Emerging Therapeutic Agents Through Targeting Cellular Homeostasis for Ageing and Cardiovascular Disease ATF4 EIF2A XBP1 TRAF2 PMC6685071__F2 Impact of oncogenic pathways on evasion of antitumour immune responses APC IL33 BATF3 CCL4 PTEN CXCL2 CCL5 CXCL10 MYC CD47 CTNNB1 PMC6610439__F11 NAD(H) recycles (not shown) in redox and dehydrogenase reactions and supplies mitochondria to generate ATP NNMT NAMPT PMC4884942__F1 Targeting Notch to overcome radiation resistance EGF HDC JAG2 ADAM10 NOTCH2 NOTCH3 FURIN NOTCH1 PMC10505163__F9 Hallmarks of severe asthma and the possible role of the identified mRNAs by artificial intelligence methods PTBP1 TLR4 PTEN MTOR MYD88 PMC6056231__F9 Neural crest induction by Dkk2 and Wnt8 SNAI2 AXIN1 LRP5 LRP6 DKK2 CTNNB1 PMC5595898__F6 Terpenoid biosynthesis in M GGPS1 MVD FDPS MVK PMC4741883__F8 Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma GATA2 SIX1 MSX1 TLE4 SPIB MAPK7 HDAC9 MEF2C EYA1 GATA3 PMC7843791__F2 Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer MGA OGA OGT GNAL PSPH PMC9034286__F6 Monitoring the induction of ferroptosis following dissociation in human embryonic stem cells GPX4 SLC7A11 RHO PMC7843791__F1 Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer FBP2 FBP1 GSK3B TIGAR HEL-S-30 PMC9352111__F5 EIF2 signaling pathway: Male 2-year turquoise module ACHE TH INA PMC9352111__F4 Opioid signaling pathway: Males 7-week green module TH BAD BRAF PMC9592740__F2 Kölliker’s organ-supporting cells and cochlear auditory development RPS16 JUN SGK1 APOE BCAM COL4A2 CTSK IRX1 MTOR PMC7825156__F6 Metabolic disturbances in PD DIO1 LOX CYP7A1 GCA HSD3B7 CYP7B1 CYP27A1 PMC7843791__F9 Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer NASP CAD ALDH18A1 NHS HEL-S-11 ATF4 ASNS PRODH PMC7433406__F8 Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NFKB Signaling Pathway BAX HMGB1 GFAP TLR4 IL1B PMC8321659__F9 Scheme showing the main alterations found in aging neurons in vitro NPC1 SREBF2 MTOR PMC2957845__F6 Scheme of the Wnt signalling pathway including proteins from the RT-PCR array CCND3 APC LRP6 PITX2 CTNNB1 BCL9 FRAT1 CXXC4 SFRP4 FBXW2 CTNNBIP1 PORCN CCND2 FOSL1 CSNK1G1 EP300 NLK CCND1 PMC7564329__F6 Proposed molecular mechanism underlying increased neural excitabilities and susceptibility to ischemic injury caused by IL-4 deficiency SCN1A IL4 GABRA6 PMC5126841__F9 Schematic representation of the study IFNG COX2 IL1B PMC5337960__F7 Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells DVL1 STAT3 PIK3CA RAF1 FUT2 PIK3CD PIK3R2 DTX4 SMAD2 GSK3B SPARC PIK3R1 CD46 SDC4 SMAD4 PTPRC DDR2 HIF1A TCF4 TUBB6 MYC BCL9 EZR LOX FYN SNAI1 FOXC2 TOB1 CD9 ABCC3 MMP2 NRAS SMO ZEB2 HES1 NOTCH1 CDH2 SRGN SNAI2 FRS2 ID2 APC SLC2A3 HEL70 IL10RA JAM3 VCAN TCF3 FZD4 AXIN1 GSC LCN2 GRB2 CXCR4 KRT18 F11R TNC EGF HEL113 HGF HMGA2 EGFR TNS1 XBP1 TGFBR1 CTNNB1 TGFBR2 MYLK CSF2RB ADAM17 SYNM FHL1 FZD1 JUP TUBA1A PDGFD EGR1 F13A1 PTPN11 MMP9 ARHA RBPJ MAML1 SMURF1 IGFBP5 FGF20 DKFZp686P11128 GNG11 FGF18 PMC2698936__F2 Integrins in Lens Development and Disease IGF1R GRB2 SRC PMC4741712__F4 An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer RASGRP3 CARD11 UBE2W PIK3R1 KDELR3 WIPF1 PRKCZ TRIM2 SLC26A2 IKBKG STUB1 FYN BCL10 UBE2D4 PDPK1 TPM3 UBE2D3 CHUK KCNMA1 CINP YWHAG DCTN6 UBE2U RAB24 ICAM3 SELL USO1 UBE2E2 VAV1 IRS1 UBE2D1 INPP1 HEL-S-71 PRKCI UBE2H tal-1 LIG1 PRKCQ UBE2D2 UBE2E3 CASP3 SIRPA UBE2E1 LYN LCK PMC4058638__F1 Core phosphatases of the PI 3-Kinase pathway PHLPP1 PHLPP2 PTEN PMC5832853__F7 Pathways regulated by selected HPG axis-related hormone and protein in male reproduction as predicted by Pathway Ontology Database and KEGG Pathway Database NCOR2 TMF1 KISS1 STAR CGA GNRHR CYP11A1 CRH NR0B2 LHCGR FSHB PMC3837380__F7 The Potential of 11C-acetate PET for Monitoring the Fatty Acid Synthesis Pathway in Tumors FASN MTOR PMC7072466__F3 Expression profiles of key genes that are involved in the characteristic metabolite biosynthesis pathways in tea plants CAD ASL GC PMC6054847__F3 Effect on eukaryotic translation initiation factors (EIF2) signaling pathway in plasma of total mRNAs obtained from D-tocotrienol treatment of hepatitis C patients ELF1 SUI1 ATF4 GRB2 EIF2A PMC5832853__F8 Mechanism by which ECH enhances the sperm counts GNRHR PROC PMC10967111__F8 RTEL1/JNK/ELK-1 signaling-induced tumorigenesis of glioma TERT RTEL1 PMC11941992__F3 The mechanisms by which visceral obesity is a triggering factor for both systemic inflammation and insulin resistance (IR) HEL-S-92n NLRP3 INSR TLR4 APC ANGPTL2 MTOR INS PMC6970023__F1 Concept of the tubal precursors ATR MIB1 ATM STIL PMC11941992__F2 Three main signal transduction pathways associated with GPR120/FFAR4 stimulation: —ANTI-INFLAMMATORY EFFECTS via beta-arrestin 2 (ARRB2) signaling in immune pro-inflammatory cells FAS MAP3K7IP1 NLRP3 TLR4 GIP PMC4131434__F4 The enemy within: endogenous retroelements and autoimmune disease TBK1 CGAS IFI16 IRF3 PMC6789287__F7 Diagram of Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways CASP9 BAD GSK3B CASP3 PMC4741712__F2 An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer PRMT1 JUN IFNGR1 UBE2W IRF1 RPS27A IRF3 IRF7 CXCL10 IFNG STAT1 DDX24 IDO1 NFKB1 RELA IRF2 PIAS1 ZHX1 PMC4445242__F3 Catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway PLCG1 CD37 ITK GRB2 PMC7851912__F7 The NELFE/Beta-catenin/CSNK2B signaling axis in GC progression CSNK2B CTNNB1 PMC7471355__F3 Different roles of mTOR signaling in stress granules assembly MTOR DEPTOR EIF4E PMC4116492__F1 Targeting FANCD2 for therapy sensitization FANCD2 ATR ATM CDK4 PMC6282995__F1 Retrograde neurotrophic signalling organelles and their main destinations after arrival to the cell body LAMP2 NGF BDNF CD63 PMC7898179__F6 Input-output signal processing plasticity of vagal motor neurons in response to cardiac ischemic injury GRPR VIP TH CCK EBP DBH TRPC6 SST NPRC PMC11663375__F3 The core regulatory pathways involved skin inflammaging (including NFKB/RIG-I, mTOR, TGFB, AMPK–SIRTs pathways) SIRT7 HEL-S-62p RELB SMAD2 SMAD4 MTOR SIRT2 SIRT3 GSDMD NLRP3 C9 ATG5 SIRT6 MASP2 SIRT4 SIRT5 SMAD6 ARHA DEPTOR RHEB MASP1 C2 MAP3K7 ADAM10 SMURF2 SIRT1 PMC4743686__F8 A proposed role of Coa6 in the mitochondrial copper delivery pathway to Cox2 COA6 SCO1 SCO2 PMC7880663__F3 Role of astrocytes in post-traumatic synapse loss and repair STAT3 MMP3 EPHB1 PMC3710315__F2 Identification of STAT target genes in adipocytes IFNG OSM PRL LIF PMC7688896__F2 Signaling pathways that regulate ADF/cofilin phosphorylation and dephosphorylation during LTP and LTD CDC42 CDH2 LIMK1 ARHA CTNNB1 PMC11940282__F4 Hepcidin regulation in hepatocytes STAT3 SMAD1 JUN TFR2 DKFZp781O1323 KEAP1 SMAD6 SMAD4 HAMP ERFE BMP6 TLR4 BMP2 HFE PMC8539850__F6 Decreased exosome-delivered miR-486-5p is responsible for the peritoneal metastasis of gastric cancer cells by promoting EMT progress ACTR3 MAL GC PMC8262738__F4 Mergeomics 2.0: a web server for multi-omics data integration to elucidate disease networks and predict therapeutics A1BG FYN HEL-S-162eP CCR2 CCR7 IL2RG CTLA4 LCK PMC7137223__F4 CeRNA network in this study PPIB SHOX ABHD15 ADD2 PEX26 NPTXR MLEC PKNOX1 STX16 PDPK1 RPL28 TMEM184B PRKCA LLGL1 PRKAR1A TRIB3 CCDC125 OLFML2A HSPA12B LAMP5 EPM2AIP1 ZC3H12B FOXK1 RNF11 MFRP ZBTB43 KHSRP BLOC1S3 ZNF623 SMC1A PTK2B ZNF581 PURB FAM131B TMEM239 SNX27 RNF157 SFMBT2 PLXNA1 GSTM3 PACS2 ATXN1 ZNRF3 AGTRAP WASF2 ZNF783 LHPP TRIM7 FBXW8 ANKRD40 ZNF547 MYO3A IGF1R HAVCR2 TGFBR2 CDK19 ZNF609 MDM4 AFF1 KIF1C USP27X BAZ2A TUB SYNM TPM3 IRAK3 MYH9 IQSEC2 RAB36 FAM118A NF2 TFDP2 MLXIP ZC3H4 STEAP2 CFL2 DCAF7 DDA1 PDE7B ARIH2 PTCD3 SLC12A7 RAB3B MKI67 RBL1 ARPP19 MALL ATP6V0A2 PHYHIP SMYD4 SLC1A2 KLF13 YWHAZ PMC8262738__F3 Mergeomics 2.0: a web server for multi-omics data integration to elucidate disease networks and predict therapeutics CD3D SYK FMNL1 MS4A1 CCL18 LTA FAS LTBR LAT NFKB2 KLRB1 IL2RG CR2 UCP2 BTK GPR18 FYN HLA-E EPOR ITK VOPP1 OAS2 ICAM2 CD48 CD2 SELL TNFSF13 GZMK CD14 GZMA TNF RUNX3 VCAN SAG FPRL2 CFP GRB2 CD3E PMC7137223__F3 Integrated protein-protein interaction network in present study PPIB SHOX ABHD15 ADD2 GOLGA3 PEX26 NPTXR MLEC PKNOX1 STX16 PDPK1 ICMT RNF24 RPL28 PRKCA LLGL1 PRKAR1A TRIB3 CCDC68 CCDC125 HSPA12B STK40 EPM2AIP1 ZC3H12B FOXK1 MFRP ZBTB43 KHSRP SMC1A PTK2B ZNF581 PURB WNT7B UBXN2B TMEM239 TRIM73 SNX27 TRIM74 SLC35F1 SFMBT2 PGPEP1 ATXN7L3 ZNF562 IPCEF1 ZNF555 GSTM3 SAR1B CXorf58 PACS2 ATXN1 ZNRF3 AGTRAP WASF2 ZNF783 FBXW8 ANKRD40 ZNF547 CHAC1 MYO3A CACNG8 IGF1R RORA FAM168A CLCC1 CDK19 ZNF609 AFF1 KIF1C TUB SYNM TPM3 MYH9 RAB36 NF2 TFDP2 ZC3H4 STEAP2 PDE7B PSMD11 PDE11A SLC12A7 RAB3B MKI67 ARPP19 RAB15 SMYD4 POU2F1 SLC1A2 KLF13 YWHAZ PMC8298376__F5 New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids TES TH BAX BAD LTA FAS CYCS RELA SI CRADD HRK SET PMC7137223__F2 MiRNAs-mRNAs regulatory network PPIB SSR1 ABHD15 ADD2 GOLGA3 PEX26 NPTXR MLEC GRM4 PKNOX1 STX16 ICMT RNF24 RPL28 PRKCA CCDC68 CCDC125 HSPA12B LAMP5 STK40 CYP8B1 FOXK1 KHSRP ZNF623 SMC1A PTK2B ZNF581 PURB WNT7B TRIM73 SNX27 TRIM74 SLC35F1 PGPEP1 ZNF607 ATXN7L3 ZNF562 ZNF555 MAST3 CLN8 OATL1 AGTRAP ZBTB8B ZNF783 LHPP ANKRD40 UGGT1 ZNF547 MYO3A CACNG8 RORA FAM168A HAVCR2 ZNF609 KIF1C TUB SYNM TPM3 MYH9 RAB36 NF2 MLXIP STEAP2 CFL2 DCAF7 PDE7B PSMD11 SLC12A7 EIF5 RAB3B MKI67 RBL1 ARPP19 RAB15 MACC1 MALL ATP6V0A2 VANGL1 POU2F1 YWHAZ PMC4167887__F1 Schematic overview over the creatine pathway HEL-S-20 HEL-S-29 PMC4642568__F2 RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli MAVS IKBKE TANK IRF3 TMEM171 PIN1 IKBKG RNF125 ATG12 NFKB1 IKBKB CHUK MAPK12 TRAF2 CYLD NFKBIB PMC5499521__F1 Curious origins of Angioimmunoblastic T-Cell Lymphoma STAT3 TET2 ICOS FYN CXCR5 STAT4 IL6 ARHA BCL6 PMC9656460__F1 Ferroptosis of Endothelial Cells in Vascular Diseases POR STEAP3 GPX4 DHFR LPCAT3 FACL4 SLC7A11 PMC11968978__F4 Crosstalk between Wnt and FGF signaling pathways FRS2 GRB2 CTNNB1 PMC11968978__F3 Overview diagram of Hedgehog pathway, Notch pathway and TGFB pathway SUFU SMAD2 DLL4 DHH JAG2 SMAD4 SHH IHH SMO DLL3 HES1 HES5 PMC11968978__F2 Non-canonical Wnt pathway signaling encompasses two major branches: the Wnt/PCP (Planar Cell Polarity) pathway and the Wnt/Ca2+ pathway ROR1 ROR2 RYK ATF2 ARHA NLK DAAM1 PMC11968978__F1 Canonical Wnt pathway signaling ZNF3 RNF43 TNKS EGFR APC SOX2 LRP5 LRP6 MYC CTNNB1 PMC2762706__F3 Hypoxia signaling pathway in DM patients 4d post-CPB/C SUMO1 HEL-S-133P EPO VEGFA VHL PMC11968978__F8 Wnt signaling pathway in various cancers, including colorectal cancer, hepatocellular carcinoma, lung cancers, chronic myeloid leukemia, triple-negative breast cancer, melanoma, and glioblastoma multiforme GREB1 HCCS RNF146 APC GSK3B LRP5 ATF2 MTOR ARHA RAC1 CTNNB1 ZFX NR2A1 FZD3 BCR TSPAN12 DVL3 CCND1 DAAM1 PMC5835104__F2 The RT2 Profiler Array gene expression data using Ingenuity Pathway Analysis (IPA) software JUN CSF2 IFIH1 IRF1 CCL5 TRAF6 STAT1 TLR3 NFKBIA MX1 CCL4 TLR7 IL1B PMC7692350__F1 Molecular signaling pathway underlying NETs formation induced by different stimulus TLR4 SRC MPO PMC11968978__F6 Wnt signaling pathway plays a crucial role in modulating the immune microenvironment of tumors IDO1 IGFBP1 LRP5 LRP6 CCL4 FOXP3 PMC11968978__F5 Wnt signaling pathway in cancer stem cells (CSCs) ROR1 LRP4 PMP22 ROR2 LRP5 LRP6 EZH2 RYK CTNNB1 HOXA5 CD44 ZNF3 RNF43 BCL2 GPR49 PMC1087506__F8 IRAK1 functions in the TLR and IL-1B pathway upstream of convergence with the TNFA pathway JUN TRADD TRAF6 TRAF2 FOS IRAK4 MYD88 PMC8914279__F1 Association of Viral Infection With the Development and Pathogenesis of Systemic Lupus Erythematosus ME3 BACH2 BCR EZH2 XBP1 PMC8305981__F2 Lysophospholipid Metabolism in Chronic Myelogenous Leukemia Stem Cells LPA GDPD3 CTNNB1 PMC11968978__F9 Small molecule therapeutic drug map targeting all parts of the Wnt pathway COX1 APC GSK3B LRP5 LRP6 RYK CTNNB1 ZNF3 RNF43 C2 PORCN COX2 DKK1 PMC4157753__F1 Retinal degeneration in animal models with a defective visual cycle RPE LRAT RPE65 ABCA4 PMC4882250__F5 Characterizing strain variation in engineered E. coli using a multi-omics based workflow RPE LDHD CS PMC7884239__F1 Role of ACE (angiotensin-converting enzyme)-2 in the pathogenesis of coronavirus disease 2019 (COVID-19) ADAM17 ACE2 PMC11802338__F3 Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood–Brain Barrier and Neuroinflammation RIPK3 PGAM5 MLKL PMC11802338__F2 TNF‐A/TNFR1 mediates the major signaling pathway of necroptosis C7 TRADD TNF TRAF2 FADD PMC3356006__F2 Central regulation of leptin signaling, autonomic innervation of the adipocyte and Beta-cell, and the starvation response LPL TG MARCKS PMC12250049__F1 Hippo signaling pathway LATS1 MOB1A MOBKL1A LATS2 TEAD2 TEAD3 TEAD4 PMC8226607__F1 Neuroprotection in Glaucoma: NAD+/NADH Redox State as a Potential Biomarker and Therapeutic Target NAPRT SARM1 HEL-S-90n NAMPT PMC10040812__F8 Signaling protein GIV/Girdin mediates the Nephrin-dependent insulin secretion of pancreatic islet B cells in response to high glucose ARHA SRC RAC1 PMC5348403__F4 Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway MCAM ITGA1 ITGA2 DVL2 MMP9 VEGFA ITGB3 PMC6896004__F9 A proposed pathway of DOCK1 in the regulation of growth and motility of CLBC cells RRP1B RAC1 DOCK1 PMC5405508__F6 Network analysis of apoptotic genes modulated in response to V3000 and V3034 infections in spleen at 24 h pi ST8SIA4 S100A4 LIMS1 CD2 SCD S100A10 BRAF MAFB DCT CCNI ILF3 IFI16 SATB1 SKI GNG2 PTTG1 TRIM24 CCL21 PPP2R2A HSPA2 RB1CC1 LCN2 OAS1 REV3L PMC5405508__F8 Network analysis of inflammatory genes modulated in response to V3000 and V3034 infections in brain SAA1 CD2 EGR1 EPHA2 OSM STAT2 IGBP1 CAMK1D SPDEF SOCS3 FOS NFKBIA ERBB2 VCAM1 PMC9121494__F1 Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer NPAS2 NR1D1 RORB RORA PMC12104300__F2 Interactions of the Eph/ephrin system in adenoid cystic carcinoma (AdCC) EPHA2 EFNA1 PMC5405508__F7 Network analysis of inflammatory genes modulated in response to V3000 and V3034 infections in spleen SOCS1 HSPD1 PSMB8 ANXA2 FPR2 ARHA CCL5 HLA-A PMC12104300__F1 Eph/ephrin signaling in oral squamous cell carcinoma (OSCC): regulatory pathways, tumor progression, and therapeutic implications EFNA3 EPHB4 EPHA8 EFNA4 EPHA2 EGFR EPHB6 MVD EPHA4 MTOR EPHA1 EPHA7 PMC6440158__F9 A working model of circPPP1R12A-73aa on promoting tumor pathogenesis and metastasis of CC via activating Hippo-YAP signaling pathway LATS1 LATS2 PMC9121494__F2 Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer NPAS2 SMOC2 TIMELESS PER2 CSNK1D CRY2 GSK3B ARHA MTOR PARP1 CTNNB1 PMC7780023__F4 TET2: A cornerstone in normal and malignant hematopoiesis STAT3 TET2 TRAF6 PMC2933229__F3 The Proneural Molecular Signature Is Enriched in Oligodendrogliomas and Predicts Improved Survival among Diffuse Gliomas ATF3 OLIG2 MYC PMC4538774__F4 Representation of the adherens junction pathway map from KEGG CDC42 LMO7 FER INSR FGFR1 SMAD4 IQGAP1 IGF1R ARHA NLK SRC CTNNB1 PMC3367865__F3 Molecular Biology of Lung Cancer: Clinical Implications TSC2 STK11 TSC1 RASSF1 NF1 EGFR KIT ERBB2 MTOR CCND1 PMC8912576__F2 Mining of Potential Gene Resources for Breeding Nutritionally Improved Maize LPA PC PMC3367865__F5 Molecular Biology of Lung Cancer: Clinical Implications BAX BAD CDK6 CDK2 BCL2 PTEN MDM2 MYC SEMA3B CCND1 CDK4 PMC3367865__F4 Molecular Biology of Lung Cancer: Clinical Implications BAD TGFA STK11 GSK3B EPO PTEN HIF1A MTOR TSC2 TSC1 CDK6 MDM2 JAK1 CCND1 CDK4 PMC3366440__F1 Protective and pathogenic functions of Th17 cells IL17F IL-21 STAT3 LTA IL17A FOXP3 PMC4855030__F5 Interaction network of innate immunity related proteins MOV10 RPL19 CRK FXR1 DDX1 ELAVL1 CALM1 TUFM ILF3 PCBP1 YBX1 DDX3X PMC7524833__F1 Interleukin-2-inducible T cell kinase plays a central role in the signal transduction of the T cell receptor PLCG1 LAT APC ITK VAV1 IRF4 LCK PMC3896120__F8 Schematic diagram of EGFR-invadopodia signaling pathways altered by Abl inhibition in HNSCC HBEGF EGFR SRC PMC5992580__F1 Gene clusters identified via gene interaction analysisLines indicate a physical interaction, as assigned by the GeneMANIA plugin for Cytoscape CEP164 LIMS1 ATR CASP8 MSH2 TNFRSF10B BRCA2 ACIN1 NBN PRKDC FGA PALB2 MAP2K3 DCTN1 PMC5395663__F1 Mesenchymal-­epithelial interactions during digestive tract development and epithelial stem cell regeneration BARX1 CDX2 FOXF1 SOX9 SHH FOXF2 SFRP1 GATA3 PMC5833418__F9 Summary of the mechanism of NCK1-AS1 in CC cells SP1 PCNA PMC7190872__F1 Toll-like receptor pathways TIRAP TLR9 TLR5 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC7190872__F2 Crosstalk between TLR4, NLRP3 inflammasome, and complement promotes neuroinflammation in Alzheimer's disease NLRP3 TIRAP TRAF6 IL1B MYD88 PMC7072681__F1 Growth factors, such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and fibroblast growth factor (FGF) bind receptor tyrosine kinases (RTKs) on the cell surface EGF EGFR MTOR CDK4 PMC8572559__F2 JAK–STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms STAT3 PMC3275500__F1 The Ras-MAPK and TGFB pathways SMAD2 SMAD4 GRB2 PMC6234768__F6 Mechanistically distinct regulation of VEGF secretion in MDA-MB-231 TNBC and T47D (ER+/PR+/HER2-) cells EGR1 SP1 OSM LIF HIF1A PMC3367865__F6 Molecular Biology of Lung Cancer: Clinical Implications APC GSK3B SMO HES1 GLI3 PMC3124653__F1 Systems pharmacology assessment of the 5-fluorouracil pathway FDXR RRM1 RRM2 DHFR TNFSF6 DPYD DUT TYMS DTYMK NME2 TK1 NFKB1 UCK2 DPYS UNG GGH UMPS FPGS PMC11215755__F3 Signalling and epigenetic mechanisms limiting the efficacy of PI3K inhibitors CDK6 BRCA1 INPP4B PDPK1 PI3 MLL2 PTEN CCND1 CDK4 PMC3124653__F6 Systems pharmacology assessment of the 5-fluorouracil pathway FDXR RRM1 RRM2 DHFR TNFSF6 DPYD DUT TYMS DTYMK NME2 TK1 NFKB1 UCK2 DPYS UNG GGH UMPS FPGS PMC7886970__F3 CD40/CD40L signal pathways STAT3 JAK3 RELB TRAF5 TRAF1 TRAF3 SRC TRAF6 TRAF2 PMC11215755__F1 PI3K pathway in non-malignant cells and cancer RHEB TSC2 TSC1 PDPK1 PTEN PMC2697682__F1 Interaction of AEA with CB and TRPV1 receptors and its metabolism by FAAH and COX-2 COX1 TRPV1 FAAH PMC9661339__F2 NLRP3 Inflammasome in Parkinson’s Disease and Therapeutic Considerations NLRP3 CD36 TLR4 PMC9120845__F2 Aberrations in the Cross-Talks Among Redox, Nuclear FactorKB, and Wnt/Beta-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome KYNU KMO LYZ SLC6A19 PITX2 STS POR EPX BCL9 HLA-DRA LPO ELANE AADAT HBB PMC9120845__F1 Aberrations in the Cross-Talks Among Redox, Nuclear FactorKB, and Wnt/Beta-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome CD3D TJP1 CCR5 CCR2 SLC6A19 ALB BCL9 CD74 DKK1 POMC KREMEN1 CSF2 LRP5 LRP6 IL10RA FCGRT CTNNA1 IL10RB TNFRSF1B EGFR CD69 RELB MC4R IQGAP1 LYZ GPX1 CTNNB1 IL1R2 OPRK1 HLA-DRA AGRN TLR4 ELANE ACE2 CRP CD81 HMGB1 IL10 CCL11 CD14 CD19 TCF7L1 PITX2 HBA2 AXIN2 RSPO1 AGER NFKBIA SKP1 ERBB2 EP300 HP TRAF2 LEF1 LCK FADD PMC7171049__F6 MiR-29c alleviates renal fibrosis via TPM1-mediated suppression of the Wnt/Beta-catenin pathway TPM1 TGFB1 APC CTNNB1 PMC5564444__F1 DNA damage and its links to neurodegeneration TDP1 PNKP LIG1 FEN1 PCNA APTX PARP1 PMC9584744__F2 Effect of Liraglutide on Serum TSH Levels in Patients with NAFLD and its Underlying Mechanisms MGA TNC BAD HP PMC4523383__F1 Synthesis of estrogen, progesterone and testosterone from cholesterol CYP11A1 HSD3B1 HSD17B1 PMC9393179__F3 Favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms IFNG IRAK1 IL1B PMC6468558__F2 Summary and functional network target analysis of ginsenoside Rb1, which exerts significantly anti-obesity, anti-hyperglycemic, and anti-diabetic effects on diabetes via multiple links across regulatory mechanisms and multi-target effects RB1 EBP IL16 PMC5958082__F2 ADT DEGs enriched in integrin signaling pathway-associated transcripts HEL114 ARSK ZYX PMC7918591__F4 Crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle pathway (CETCH pathway) HBD MMD PMC4355473__F2 Change in TNFR1 signaling pathway in 3 h, 12 h, and 24 h groups after cerebral ischemia-reperfusion injury HTRA2 BAX TRADD GCK FADD PMC7075814__F3 Synthesis, release, and activation of TGFB signaling via the canonical pathway TEC SMAD4 PMC4727203__F1 Regulation of actin cytoskeleton pathway CDC42 ABI2 EGF FGF12 FGF14 SOS1 FGF21 BRAF GNG12 APC2 RAC3 MYLK FGF7A F2R F2 WAS FGF16 CFL2 FGF22 ROCK2 SSH2 APC HEL70 FGF2 HEL114 CRK MOS SOS2 PDGFRA SSH3 ARHGEF4 CSK FGF20 ARHGEF7 FGFR3 RRAS WASF2 BAIAP2 RRAS2 FGF18 PMC6215844__F2 Iron and inflammatory signaling to hepcidin TF STAT3 SMAD1 TFR2 DKFZp781O1323 SMAD4 HAMP HFE2 BMP6 BMP2 HFE JAK1 TMPRSS6 PMC7075814__F4 Signaling via the non-canonical pathway of TGFB SMURF1 ARHA MTOR TRAF6 PMC524242__F1 Proposed schematic of chemokine-induced traffic and activation of DCs following DNA vaccination with plasmid-encoded Flt3L and MIP-1A CD83 CD80 APC CCR7 PMC6280292__F8 Antitumor effects of emodin and chrysophanic acid SP1 EGFR MTOR PMC2694412__F6 Somatic mutations affect key pathways in lung adenocarcinoma STK11 EGFR APC PTEN MTOR CTNNB1 RB1 CDKN2A TSC2 TSC1 INSR NF1 ATM MDM2 PMC8318568__F2 An Ecological Basis for Dual Genetic Code Expansion in Marine Deltaproteobacteria DDT GC PMC9294349__F2 Endothelial Cells as a Key Cell Type for Innate Immunity: A Focused Review on RIG-I Signaling Pathway TBK1 MAVS IL13 IRF3 IRF7 ISG15 OAS2 IL1B PMC4671321__F5 Predicted model for the action of GSK3B in buffalo embryonic stem ( ES ) cells DKK1 LIF GRB2 CTNNB1 PMC8261484__F1 NAD+ synthesis pathways NAPRT SLC29A4 SLC29A3 HEL-S-90n KYNU KMO NAMPT SLC6A19 AFMID SLC12A8 SLC22A13 SLC5A8 SARM1 SLC29A1 HAAO PMC5653760__F6 Resveratrol has multiple biological functions that are relevant for AD MID1 BACE1 APP ADAM10 MTOR PMC8096869__F2 Proposed stem cell concept for the development of leiomyomas CD44 MED12 CTNNB1 CD34 PMC12250459__F4 Neuroprotective mechanisms of AOF BAX BAD MTOR TRAF6 IRAK4 MYD88 TREM2 TSC2 MAP3K7IP1 IGF1 TLR4 GRB2 SRC BDNF REL PMC7594413__F2 The MAPK pathway is here shown GSK3B BRAF GRB2 PMC9301111__F2 Uncovering the Underlying Mechanisms of Ketamine as a Novel Antidepressant RHEB EEF2K TSC2 NRG1 SIAH1 ERBB4 HEL-S-162eP EEF2 BDNF PMC6704159__F7 The cooperation between M and P proteins to inhibit different Jak-Stat-pathway steps STAT1 ISG15 JAK1 TYK2 PMC6024232__F2 The pathway of acylceramide synthesis in keratinocytes ELOVL4 CERS3 CYP4F22 ELOVL1 KDSR PMC5245686__F2 Metabolomics and Metabolic Diseases: Where do we stand? CIC PC HEL-S-26 PMC4928174__F2 Canoncial and non-canonical Reelin signaling CDH2 DAB1 CDK5 PMC3491089__F4 Schematic representation which shows possible mechanisms of action by D- and Gamma-tocopherol in multiple signaling pathways involved in mammary carcinogenesis BAX CASP9 CDK6 PCNA KEAP1 CASP3 BCL2 PTEN CCND1 CDK4 PMC4928174__F1 Core Reelin signaling pathway CDH2 CRK VLDLR GSK3B PMC7696795__F1 Activation of JNK by proinflammatory cytokines TNFA and IL-17 leading to autoimmune arthritis TRADD TRAF6 TRAF2 PMC10869406__F5 Relationship between major genes and the PI3K/AKT/mTOR signaling pathway ARHGAP1 ROCK2 CTSL MTOR ARHA EIF4E ANXA11 IGF2R HEL-S-47e CD74 HEL-S-130P CAMK2D CALM1 MAP2K2 EIF4A1 RTKN PMC8935230__F8 Melatonin reverses tumor necrosis factor-alpha-induced metabolic disturbance of human nucleus pulposus cells via MTNR1B/GAi2/YAP signaling LATS1 ACAN POR MTNR1B COL2A1 PMC5256616__F4 RGS6 in central nervous system diseases TH RGS6 HP PMC5964982__F2 Notch signaling pathway TGFBR2 HEL-S-14 ADAM10 NOTCH2 NOTCH3 FURIN RBPJ NOTCH1 TGFBR1 PMC5256616__F6 Schematic illustrating the G protein-independent role of RGS6 in doxorubicin-induced apoptosis and antiproliferative signaling in the breast DRAM1 BAX RGS6 ATM PMC8263635__F11 ELOVL2: a novel tumor suppressor attenuating tamoxifen resistance in breast cancer MLST8 ELOVL2 TGFB1 BMF ERG ELOVL5 PMC9537819__F1 Dietary meat mutagens intake and cancer risk: A systematic review and meta-analysis NAT2 CYP1A2 PHIP PMC8269395__F5 Emerin Represses STAT3 Signaling through Nuclear Membrane-Based Spatial Control STAT3 MYOG IL6 PAX7 PMC3459479__F1 RAS pathway and its correlation with RASopathies CBL SPRED1 SOS1 SHOC2 BRAF CS GRB2 PMC2706609__F1 ERK1/2 pathway in airway epithelial cell responses to cigarette smoke EGF RAF1 SP1 EGFR GRB2 PMC12214337__F12 Comprehensive Computational Assessment of SNAI1 and SNAI2 in Gastric Cancer: Linking EMT, Tumor Microenvironment, and Survival Outcomes SNAI2 MMP11 SDC3 PMC8054829__F1 Type I interferon in the pathogenesis of systemic lupus erythematosus STAT4 IRF7 MYD88 PMC8170976__F9 Parkinson mice show functional and molecular changes in the gut long before motoric disease onset ARPC4 VAMP2 HEL-S-77 PTPRN NEFL ATOX1 TPM1 UBE2V1 NAPG SYNM HEL-S-14 SCGN CALB2 PMC3739200__F1 Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK/STAT signaling pathway RAF1 GRB2 BDNF PMC6769444__F5 Proteasome pathway mapping of altered genes in DLD-1-miR-21 cells IFNG RPE REN RMI2 RP2 RPN1 ARC POMP PMC7192829__F2 Regulatory mechanisms involved in vitamin D-induced autophagy NR1i1 TLR1 TFEB TLR8 HEL-S-11 MTOR PMC1449579__F1 F igure 1.— RAD18 PCNA PMC7710911__F2 ACAs and CENP-B: CENP-B bound to CCR3 HBEGF EGFR CCR3 SRC CENPB PMC7870526__F2 Metabolic regulation of lung myofibroblast activation GLS PHGDH F2 HK2 PSAT1 HEL-S-51e PSPH PMC12061715__F4 Analysis of the mechanism of skeletal muscle atrophy from the pathway of decreased protein synthesis STAT3 GDF8 SMAD2 SMAD4 ATF4 SOCS3 GADD45A PMC4429297__F4 Network-Based Identification of Smoking-Associated Gene Signature for Lung Cancer EGF SEMA3C PIGN E2F3 GPRC5C EGFR HEL110 ABCA3 KRAS E2F5 CYP3A4 CRTAC1 PMC12061715__F2 Detailed mechanism of GSK3B involvement in reduced protein synthesis RICTOR IGF1 NFATC3 IRS1 CTNNB1 PMC6382829__F5 ZINC24469384 regulates genes involved in P53 and STAT signaling pathways JUN HEL-S-11 IL6 GRB2 MTOR CEBPB PMC7079998__F3 STAT3 roles in viral infection: antiviral or proviral? STAT3 EGFR SOCS3 MTOR SRC PMC9096207__F4 Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination STAT3 CXCR1 CD36 CCR2 FABP4 PMC3480720__F1 Innate immune signals during B STAT1 TIRAP TLR9 NOD2 IRF3 NOD1 ADA MYD88 PMC7714782__F1 Response of methionine metabolism in the liver HEL-S-61p MTR PMC9096207__F3 Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination CD44 POSTN HGF HMMR NOTCH3 PMC9096207__F2 Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination STAT3 POSTN CCL22 PMC7714782__F3 Metabolism of methionine in viral infections of hepatitis B and C PRMT1 STAT1 PIAS1 MAT1A PMC1449579__F5 F igure 5.— RAD18 PCNA POLG PMC2786169__F4 Topology of leukemia-related BCR-ABL pathway STAT1 BAD BCR CRKL GRB2 MYC PMC8395751__F10 Expression Profile of Genes Encoding Proteins Involved in Regulation of Vasculature Development and Heart Muscle Morphogenesis—A Transcriptomic Approach Based on a Porcine Model GEM INA APC SOX2 DUSP9 PC HAND1 RIF1 SKA1 PMC9423733__F1 Multifaceted Role of Autophagy in Endometrium Homeostasis and Disease ATG101 ATG10 ATG3 ATG12 ULK1 AMBRA1 ATG5 ULK2 PMC5360635__F1 Autophagy mechanism ATG3 ATG16L1 ATG12 ATG5 PMC4637888__F4 Novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway SUFU SHH CYC1 SMO STIL PMC1934395__F2 Combined Effects of Thrombosis Pathway Gene Variants Predict Cardiovascular Events CRP TG F5 APC THBD PMC11645450__F3 Regulatory roles of the DUB family in signaling pathways ATXN3 CD40 RAF1 LTBR WWC3 TIRAP SMAD2 OTULIN SMAD4 ATF2 TRAF3 TRAF6 MYD88 USP1 OTUD5 USP21 CYLD USP16 USP19 APC USP11 YAP1 HEL-117 USP14 TSC1 PAXX USP22 WWC2 GRB2 USP32 SIKE1 STAMBP TRADD PTEN MTOR OTUD1 CTNNB1 LATS1 YOD1 LATS2 SLMAP USP15 USP4 OTUD7B OTUB2 USP26 SMAD6 USP9X MAP3K7IP1 USP2 WWC1 RELA TRAF2 PMC7760721__F2 AB peptides are derived from the processing of the BAPP (APP) through the amyloidogenic pathway CA12 ATF4 CALHM1 XBP1 PMC7816272__F3 Dysregulation of NCC and TRPM6 common regulatory pathways TRPM7 DCT OSR1 TRPM6 PMC7057764__F1 Impact of lactic acid on tumor angiogenesis ARG1 MMP9 PMC6610018__F3 Interplay between the cGAS-cGAMP-STING pathway with mTORC1 signaling TBK1 IRF3 TREX1 PMC6610018__F2 Activation of the cGAS-cGAMP-STING pathway mediates obesity-induced inflammation and metabolic disorders TBK1 CGAS IRF3 PMC4048856__F2 HEPCIDIN AND IRON HOMEOSTASIS BMP6 TFR2 HFE HFE2 PMC2645306__F2 Migration of Airway Smooth Muscle Cells CDC42 ARHA SRC PMC11453023__F7 TLR-activating and the induced signaling pathway TIRAP TAB3 TLR9 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR8 TLR7 TRAF2 PMC10488294__F3 AML cell differentiation by S100A9 TLR4 S100A8 S100A9 PMC5766549__F6 Milk protein synthesis in bovine mammary gland PRL CRH GC INS PMC12016237__F2 Mechanisms proposed for the AS-IV action in animal models of cardiovascular disorders FAS GSDMD NLRP3 SMAD2 TNF PMC5766549__F4 Activators and repressors of the regulatory network of genes associated with the bovine milk K-casein content CDON PCLO STAC SI F11 OLAH ACR CIT PMC6319272__F2 Schematic depicting the proposed hypothesis that resistance exercise-induced adaptations may require the Hippo pathway effectors YAP and TAZ LATS1 HEL-S-31 MOB1A MOBKL1A LATS2 MAP4K3 MAP4K1 MAP4K2 PMC4803054__F7 Models depicting the multifaceted role of Mte1 in RF repair and CO promotion SMC6 SMC5 RMI1 PMC11651441__F11 Inflammatory signaling pathways of SYGCT therapy for asthma-IBS TBK1 TRADD LAT JAK3 TAB3 CCL2 TRAF6 DAO RORA TRAF4 COX2 RHOD IL17RB AHR FOXP3 USP25 S100A7 APC CXCL2 MMP9 IRF4 TNF CXCL10 FOS GATA3 MEI1 JAK1 LCN2 S100A9 FADD PMC9200548__F3 Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy TSC2 ULK1 TIPARP MTOR PMC2761108__F8 Roles of BMP signaling pathways during SNS development TH ASCL1 DBH SMAD4 HAND2 PHOX2B GATA3 PMC9200548__F1 Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy BNIP3 BCL2 ARHA GRB2 MTOR PMC6682745__F1 WNT/Beta-catenin signaling and the potential role of heterotrimeric G proteins LRP5 LRP6 CTNNB1 PMC7834777__F8 Predicted mechanism after administering TCN in the liver UCP2 NR1C1 PMC10149931__F9 Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction CDC42 FYN DGKA LCK PMC3836831__F2 Model of PfEMP1 head structure divergence CD36 APC PC PMC4704136__F2 Cellular and molecular interactions between CLL cells and the tissue microenvironment CD40 SYK CXCL12 CXCL13 CCL3 IL4 IFNG BCR MSC CXCR5 CCL4 VCAM1 CXCR4 PMC4532781__F1 PolyQ-HTT impairs autophagy HAP1 ROCK1 MTOR HTT PMC12125588__F3 Ginsenoside Rg1 in modulating myocardial hypertrophy and fibrosis CASR PINK1 RELA MMP2 MMP9 SIRT1 PMC12125588__F2 Ginsenoside Rg1 in protecting ischemic myocardium HEL-S-22 PINK1 NLRP3 OPA1 TLR4 ARHA MTOR HEL-S-44 PMC6823243__F3 SHP-2 in cytokine receptor signaling PI3 GRB2 MTOR PMC6823243__F2 SHP-2-mediated activation of ERK PAG1 GRB2 SRC PMC10380887__F1 MTOR Signaling: Emerging Role of Cyclic Nucleotide-Dependent Protein Kinases and Implications for Cardiometabolic Disease RHEB TSC2 GRB10 TSC1 SIK3 GC PTEN TNF DEPTOR PMC6514310__F2 Upstream and downstream of mTORC1 and mTORC2 SZT2 MTHFD2 CAD ULK1 PTEN RHEB TSC2 TSC1 NPRL2 C16orf35 TBC1D7 DEPDC5 SEH1L MIOS WDR24 SLC38A9 PMC6514310__F1 mTORC1 and mTORC2 MLST8 RICTOR MTOR DEPTOR PMC7432101__F1 Cartoon representation of DGK signaling in cancer HIF1A RHO MTOR SRC MYC CCND1 PMC6274804__F1 Schema illustrating the regulation of the autophagic pathway under diverse stressful conditions in cancer cells ATG101 ATG10 ATG3 ATG12 ULK1 ATG5 PMC3637678__F1 MicroRNAs regulating myogenesis via PI3K/Akt signaling IGF1 PTEN PMC2839263__F2 Emerging models for the role of Beta-arrestin in wingless (from Drosophila) and the oncogene int-1 (WNT) signalling CDC42 ROR2 LRP5 LRP6 RYK ARHA CTNNB1 PMC7859115__F3 Cellular and molecular features of autophagy ATG101 ATG16L1 ATG12 ULK1 MTOR ATG5 PMC3146004__F4 Pathway assignment of the important genes based on KEGG IFNG ARHH SP1 PCNA MAL RAE1 CDK2 SKP1 NODAL MYT1 SKP2 CA14 PMC7857022__F1 Class I PI3K signaling pathway simplified RHEB TSC2 TSC1 BCR PTEN KRAS PMC5615147__F2 Regulations of Nrf2 by several factors JUN SIAH2 KEAP1 AHR PMC4775111__F10 Scheme and coexpression network for a putative flavonol synthesis pathway in tobacco flowers PMC6928039__F7 CR3 triggers the Syk/calcineurin/NFATc pathway upon engagement by PGL-I-producing mycobacteria to rewire the innate response SYK BCL10 IL16 TNF CARD9 MYD88 PMC11877449__F3 Interactions in the Tumor Microenvironment (TME) Affecting Lung Cancer Progression VEGFA PMC12220482__F2 Mechanism of NUSAP1 in cancer NUSAP1 APC PMC10252036__F2 Various mechanisms that have been reported to regulate epithelial–mesenchymal transition (EMT) in SACC patients CDH2 EGF MYB HEL113 HGF NFIB APC GSK3B HIF1A MTOR CTNNB1 PMC5225500__F1 Glutaminolysis in cancer cells GOT2 GLS GPT2 MTOR MYC PMC3632418__F1 mTOR as a potential treatment target for epilepsy STRADA RHEB TSC2 TSC1 PTEN EIF4E PMC4702617__F2 Deletion of the RIM15 gene on the metabolic profile of a laboratory strain during alcoholic fermentation TK1 GLG1 PDC PLK1 PMC11877449__F2 PI3K/AKT/mTOR Pathway RHEB ULK1 EGFR IGF1R PMC2349095__F2 Triggering and amplification of the Wnt/Beta-catenin pathway in osteocytes in response to load TF SOST LRP5 HEL-S-28 PMC10535221__F7 HAs induced LoVo cell apoptosis and inhibited the phosphorylation of Akt BAX BAD FAS PMC11930217__F1 Key signal transduction processes of TGFB and Notch signaling pathways in renal cells SMAD4 MDM2 CCND1 HES1 NOTCH1 PMC12182320__F1 Expression profile analysis of key genes in the GSL biosynthesis pathway in B42OE, B42WT, and B42CR TH GAL BMX PMC7979572__F3 Stress, Nutrient and Growth factor signaling pathways that affect translation RPS6 EEF2K EIF4B IGF1 ELF2 EEF2 MTOR EIF4E PMC5002468__F1 Calcineurin/NFAT signaling pathway RYR2 RYR3 NGF RYR1 IGF1R BDNF PMC3894150__F1 Central Role of the PPARG Gene Network in Coordinating Beef Cattle Intramuscular Adipogenesis in Response to Weaning Age and Nutrition WNT10B ACLY PPARG SMAD1 LEP SLC2A4 CD36 MLXIPL PCK1 INSIG1 NCOR1 DGAT2 CEBPD CEBPB ADIPOR2 SCD LEPR FASN FABP4 PNPLA2 NCOR2 MID1IP1 CEBPA THRSP NR2F2 ZNF423 BMP2 ELOVL6 PMC4938774__F7 Elevated integrin A6B4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer MAX CLCA2 LAMA5 HEL113 LAMA1 EGFR PIK3R2 MST1R MYC DST LAMB1 FYN YWHAQ CD151 PRKCA ALOX12 HEL-S-1 MMP7 YES1 LAMC2 JUNB PMP22 EIF6 HRAS FOSL1 ATXN1 PMC2533786__F9 PI 3-kinase/AKT-dependent pathways involved in IL-1 induction of IL-6 PI3 TRAF6 IRAK4 MYD88 PMC9564263__F1 Systematic Interrogation of the Temperature Perturbation in the Insulin Signaling Pathway for Optogenetic Stimulation INSR GSK3B IRS1 PMC3614492__F1 Calciomics: integrative studies of Ca2+-binding proteins and their interactomes in biological systems CASR STIM1 CALY MCU PMC8432036__F2 Canonical TGFB Signaling and Its Contribution to Endometrial Cancer Development and Progression—Underestimated Target of Anticancer Strategies SMAD2 SMAD4 TGFBR1 PMC8829728__F3 Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation HMGB1 GSDMD NLRP3 TLR4 LBP IL1B PMC4973073__F4 Downregulation of PPAR pathway and bile acid biosynthesis and secretion pathway PPARG EHHADH CD36 FACL4 NR1C2 FADS2 HSD3B7 SLC27A5 CYP7A1 ABCC3 SOAT1 CPT2 TM7SF2 CYP27A1 APOC3 ACSL5 ABCB11 FABP4 AQP8 APOA2 NR1C1 ACSL1 SCARB1 EPHX1 CYP46A1 PLTP CYP7B1 PMC8829728__F4 Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation TLR4 CD14 LBP PMC9339684__F3 Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis STAT3 STAT1 CGAS MTOR GATA4 PMC5954621__F5 Bile acid regulation of bile acid synthesis CYP8B1 CYP7A1 FGFR4 CYP7B1 CYP27A1 PMC3243049__F3 The autophagy pathway is affected at different steps in the various types of dementias MTOR VCP CHMP2B PMC5928575__F2 Ovulatory cascade TNFAIP6 EREG COX1 HAS2 AREG PMC3893993__F3 RAS-mitogen-activated protein kinase signaling pathway SPRED1 SHOC2 GRB2 GAB2 PMC5954621__F2 Bile acid synthesis pathways CYP8B1 HSD3B1 CYP7A1 HSD3B7 CYP46A1 CYP27A1 PMC10525517__F2 RUNX1-Regulated Signaling Pathways in Ovarian Cancer BAX EGF TSC2 EGFR MDM2 PMC3888822__F2 Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways CDC42 ARHA PMC6791355__F2 Cdc37 controls a network of intracellular protein kinases ULK1 CDC37 PMC5928575__F5 PGE2 mediates early implantation CXCL12 EGFR CXCR4 PMC4702820__F4 Gene–gene network category and pharmacological category THRSP LGALS12 PCCA SGPP2 PECR PMC3947766__F1 Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time UNC93B1 TLR9 TLR7 PMC6370010__F3 Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain CDK5 PAK1 LIMK1 RASGRF2 RAC1 PMC3431702__F7 TLR signaling and proposed model for DMF-mediated impairment of DC maturation TBK1 TLR1 TLR3 TLR4 IRAK1 TLR5 IRF3 TLR7 TRAF6 TNF MYD88 PMC8446275__F1 Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing RAD51 BRCA1 PMC5036051__F3 Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer TF TP73 POLE2 MYBL2 EZH2 FANCA BLM FOXM1 FANCF E2F6 CEBPZ MXD3 PCGF6 EME1 PMC6985875__F1 Mitochondrial function and localization in various lung epithelial cells during homeostasis TFAM PINK1 FIS1 OPA1 MFN1 MFN2 MFF ATG5 PMC8037087__F2 Main mechanisms mediated by cannabinoids on angiogenesis, EMT, adhesion, invasion, and metastasis JUN JUNB SMAD2 SOX2 CXCR4 FOS CDK4 CTNNB1 PMC5653149__F1 Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer EGF SPARC HBD PMC5653149__F4 Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer CD36 SRC CD47 PMC8446275__F2 Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing CEP290 BCL11A PMC11186432__F4 Different regulatory functions of F-box proteins in gastric cancer CDH2 VDAC3 FBXL5 FBXO21 FBXO31 FBXW5 PTEN ARHA FBXO2 LATS1 FBXO11 FOXM1 FBXW7 PMC7693799__F7 Molecular enrichment networks of genes associated with diabesity and the cluster 3 network enrichment analysis SHC1 EGFR PIK3C2A PRKCZ RPS27A CTSS B2M MMP9 INS IL5 IRS1 INSR LDLR INPPL1 PMC5729506__F8 Schematic EGFR signaling pathway EGF MTOR CTNNB1 PMC8071398__F2 Classic signaling pathways activated by GnRH EGF RAF1 GNRHR EGFR SRC FSHB PMC3985726__F47 Canonical (yellow background) and non-canonical (red background) Wnt/Beta-catenin signaling pathways are related to mechanical elements and actions responsible for cell polarization, migration and tissue organization APC IQGAP1 RHO PMC9243238__F2 Endoplasmic Reticulum Stress and Pathogenesis of Vascular Calcification ATF4 EIF2A RUNX2 XBP1 PMC9243238__F3 Endoplasmic Reticulum Stress and Pathogenesis of Vascular Calcification ATF4 EIF2A XBP1 PMC8432036__F5 Canonical TGFB Signaling and Its Contribution to Endometrial Cancer Development and Progression—Underestimated Target of Anticancer Strategies SMAD2 SMAD4 TGFBR1 PMC9398856__F5 Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved IGF1 IRS4 TBX5 MTOR IRS1 PMC7693799__F5 Molecular enrichment networks of genes associated with diabesity and the cluster 1 network enrichment analysis ALB TNC GAS CSTA CP ADA PMC8432036__F6 Canonical TGFB Signaling and Its Contribution to Endometrial Cancer Development and Progression—Underestimated Target of Anticancer Strategies SMAD2 SMAD4 TGFBR1 PMC3887408__F1 Interactions of the Ras/PI3K/PTEN/Akt/mTOR and Ras/Raf/MEK/ERK pathways with GSK-3 RHEB RPS6 TSC2 TSC1 NF1 ULK1 PTEN GRB2 MTOR DEPTOR IRS1 EIF4E PMC9656973__F7 Visfatin-Induced Inhibition of miR-1264 Facilitates PDGF-C Synthesis in Chondrosarcoma Cells and Enhances Endothelial Progenitor Cell Angiogenesis PDGFC MTOR PMC4646468__F4 Comprehensive MicroRNA Expression Profile Related to Hypoxia Adaptation in the Tibetan Pig CDC42 CASP9 BAD COX2 MAPKAPK2 SRC PMC5379981__F6 Model whereby both uracil glycosylases and the Pms2/Mlh1 complex enable A-T base pair mutagenesis with a distinct strand bias MSH6 MSH2 PMS2 UNG SMUG1 POLN TDG PMC8674203__F2 TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers RFWD2 TC2N BAD ALK PTEN MYC PMC7348176__F7 Anticancer mechanism of HF for HCC CDK6 CDK2 CCND1 CDK4 PMC6927459__F5 Multifaceted activities of CD44v6 in PaCIC GATA2 BAD MMP14 HGF LRP5 HEL-S-28 LRP6 NR1C2 HIF1A MMP9 ARHA IGF2 YAP1 TGFBR1 CTNNB1 CD44 RUNX1 DKK1 MMP2 CDC37 GRB2 CXCR4 CCND1 PMC7016856__F2 Anti- and pro-fibrotic roles of Epac1 in cardiac fibroblasts TF TGFBR2 TGFB1 TGFBR1 PMC2649265__F8 Insulin-PI3K-Akt signaling in AD RICTOR IGF1 COCH GSK3B PDK2 MTOR INS IRS1 PMC6927459__F7 EpCAM, claudin7 and their cooperation in PaCa JUN PRKD1 IL13 APC FHL2 HEL-S-28 LRP6 PTEN ARHA CTNNB1 IFNG EPCAM TSPAN8 DKK2 PMC7016856__F3 Fibrotic signaling pathways by PKA and AKAPs ROS1 ARHA AKAP12 PMC6927459__F6 CXCR4 and PaCIC survival and motility CDC42 SHH BCL2 TSPAN8 SMO RHO CXCR4 CTNNB1 PMC8127420__F4 Epidemiological link between obesity, type 2 diabetes mellitus and cancer IGF1 GSK3B LRP5 LEF1 SIRT1 CTNNB1 PMC6865805__F2 Chronic infection of H ATG16L1 ATG12 MTOR ATG5 PMC6627106__F4 Four branches of MOB control LATS1 STRIP1 MOB2 STRIP2 RAD50 LATS2 MRE11A PMC6624780__F9 TSL suppresses angiogenesis by inhibiting the VEGFR2 signaling pathway MMP2 MMP9 CDK4 PMC3084294__F4 The Complete Genome Sequence of ‘Candidatus Liberibacter solanacearum’, the Bacterium Associated with Potato Zebra Chip Disease MAL CS CIT PMC6539837__F1 Some common metabolic features of adult stem cells are essential for the maintenance of their quiescence, number, proliferation potential, and differentiation ability UCP2 MTCH2 PDK4 HEL-S-162eP MEIS1 PDK2 MPC2 GPX1 HEL-S-44 CP PMC6539837__F4 Intensity of information flow through the mTORC1-signaling pathway defines the fate of quiescent adult stem cells RHEB HGF TSC1 PTEN YY1 PMC8292097__F10 Carbon Monoxide-Releasing Molecule-2 Ameliorates Particulate Matter-Induced Aorta Inflammation via Toll-Like Receptor/NADPH Oxidase/ROS/NFKB/IL-6 Inhibition TLR4 VCAM1 PMC11568095__F10 Network pharmacology and in vitro experiments to investigate the anti-gastric cancer effects of paeoniflorin through the RAS/MAPK signaling pathway IGF1 SOS1 MMP2 GRB2 MMP9 PMC3585940__F5 Gene Expression Profile Analysis of Type 2 Diabetic Mouse Liver EHHADH PYGL FAS NR1C1 CD36 FBP1 GCK CPT2 ELOVL6 PCK1 CPT1A PKLR PMC6428080__F1 Translational control mechanisms EGFR ELF2 IGF1R MTOR IL6 IRS1 RHEB TSC2 NGF EREG TSC1 IGF1 ATF4 EIF2A BDNF PMC2914056__F6 Pathway packaging of the 'biopolymer metabolic process' module BRIP1 MSH6 JUN MSH2 PLK3 NBN FANCA CCND1 RPA1 TP53BP1 PMC3488095__F8 A model for SAHA mediated effects on A1AT folding and trafficking OS9 EDEM3 CANX SEL1L PMC6680978__F4 The (a) glycolysis and (b) PKA-AMPK pathway genes and metabolites modulated by dietary BRBs during oral carcinogenesis ENO2 PDE10A HK2 PIK3C2G SMAD4 PGAM2 ELAVL1 HEL-S-49 CREBBP PFKL HEL-S-87p PDE4A YWHAG PMC6052044__F1 Metabolic pathway reconstruction for Spirochaetes in hydrocarbon- and organohalide-contaminated environments F5 F2 F3 PMC4970823__F2 Regulation of cancer cell functions by hyaluronan (HA)‐receptor interactions CD44 EPHA2 PATJ RHO PMC8395015__F1 Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers NOS2 ASS1 ASL HEL-S-277 ARG1 ARG2 PMC3887408__F5 Novel approaches of targeting signaling pathways in leukemia STAT3 ATF5 MTOR CCND1 SIRT1 CTNNB1 PMC3283951__F5 The acetate/mevalonate pathway for the formation of IPP, the basic five-carbon unit of terpenoid biosynthesis HCCS IPP CS PMC6834135__F1 NK cell features in chronic HBV infection CD44 IFNG KLRG1 PMC8570953__F1 Swertia chirayita suppresses the growth of non-small cell lung cancer A549 cells and concomitantly induces apoptosis via downregulation of JAK1/STAT3 pathway BAX FAS JAK1 FADD PMC5331729__F2 LncRNAs network in malignant transformation of HCC stem cells POLL CTCF PCNA CCND2 IL18 CDK2 POLI TERT PTEN IL6 SETD2 SKP2 PMC5331729__F4 Roles of LncRNAs in the malignant transformation of breast CSCs HOXD10 STAT3 SOX2 SETDB1 PMC8715196__F13 KDM6A Regulates Cell Plasticity and Pancreatic Cancer Progression by Noncanonical Activin Pathway PMC5988573__F1 Schematic diagram showing the positive feedback loop between Hippo-YAP/TAZ and IRS2-AKT signaling in the DKO livers APC PTEN PMC4008004__F1 Hyperglycemia alters the expression of multiple genes of the transforming growth factor‐B (TGF‐B) pathway through the polyol pathway in retinal vessels CD44 IFNGR2 TIMP1 COX1 TXNIP BMPR1A SOAT1 ELK3 HOXC8 NOTCH1 MXI1 TGFBR1 PMC7867545__F10 The Impact of the CMT2B-causing RAB7 mutant protein on the endocytic pathway LAMP2 HEL-S-130P CTSL TSG101 PMC12153797__F2 Core signaling networks that contribute to the development of vasculogenic mimicry CDK2 ATM PMC12153797__F1 Exploration of the VE-cadherin structure and the transformations it undergoes when it comes into contact with VEGF-A CSK SRC PMC6547810__F8 Schematic drawing of the suggested intracellular signaling pathways of LIF and OSM receptors in osteoblasts mediating expression of osteoclastogenic factors, osteoclast formation and bone resorption STAT3 SHC1 OSM OSMR LIF GRB2 JAK1 PMC12153797__F4 Pathways in immune cells that short-chain fatty acids generated by GM triggers CD44 CD24 SNAI1 SOX4 PMC12153797__F3 Correlations of microbiome and different cancers CD44 STAT3 FUT8 TLR4 PMC8019825__F8 Summary of the pathological alterations of CRS-3 SHC2 GRB2 MTOR PMC7108978__F2 Simultaneous utilization of 2H and 13C tracers provides insights into distinct pathways of hepatic metabolism HEL-S-62p C2 MAL CIT PMC10740933__F3 (Left) Initial biosynthetic pathway for the formation of a lipofuscin fluorophore A2E in photoreceptor outer segment (OS) and its structure as a component of lipofuscin (LF) in the RPE cell RPE ATR PMC9616778__F8 Cilostazol Alleviates NLRP3 Inflammasome–Induced Allodynia/Hyperalgesia in Murine Cerebral Cortex Following Transient Ischemia: Focus on TRPA1/Glutamate and Akt/Dopamine/BDNF/Nrf2 Trajectories GFAP TRPA1 NLRP3 BDNF SIRT1 PMC9304404__F7 Mechanistic diagram of apatinib in NSCLC cells ATF4 ASNS PMC3096649__F7 IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis IGF1 IGF1R GRB2 SHE IRS1 PMC2805793__F1 Ligand binding and subsequent Erbb dimer formation initiates signaling through a complex array of intracellular pathways that initiate and control a range of cellular processes ERBB3 BAD GSK3B ERBB2 PTEN GRB2 MTOR PMC7645337__F7 Core molecular net words identified by IPA HMOX1 JUN NR2A1 HK2 EPO HIF1A CTSA PMC4386979__F2 Intracellular signal paths coupled to the opioid receptors and implicated in cardiac stress signalling and cardioprotection STAT3 EGF EGFR MTOR PMC10568034__F2 Manner in which the studied product acts on the Wnt pathway in lung cancer TF APC CTNNB1 PMC3320915__F7 Model of proposed CCR7/CCL19 signaling pathway in T cells KLF2 CCL19 CCR7 PMC9690286__F1 Small Non-Coding RNAs in Human Cancer RAN DROSHA PMC7690430__F3 Targeting the PI3K–AKT–mTOR pathway to treat prostate cancer TSC2 TSC1 PTEN PMC4448502__F4 Pathway analysis showed a strong role for early response genes and sterol regulatory elements ACLY ZFP36 VWF JUND EGR1 REEP2 SREBF2 PTMS UCP2 MYLK AGR2 KRT34 PIM3 LIPE EGR2 PMC5573409__F4 Diagram of P53 signaling pathway with overlaid molecular activity prediction after heat stress PML PMC4021040__F2 Targeting glioma stem cells: a novel framework for brain tumors EGF EGFR PTEN PMC8945343__F5 Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies PGC NPS TXNIP PMC8197763__F8 Action mechanism of H2A.Z in HCC JUP SPINT1 TCF3 IGF1 CDKN1A CDK14 BCL6 PMC8945343__F4 Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies UCP2 OPA1 MFN1 MFN2 BNIP3 PMC6056717__F1 Coenzyme Q10 deficiencies: pathways in yeast and humans COG5 FDX2 COQ7 FDXR IPP ALDH3A1 COQ3 COQ2 PAH FDX1 COQ6 COG6 PMC12177077__F5 MBD2 in autoimmune diseases STAT1 MBD3 IFI35 MBD2 PMC5436564__F6 Working model of E2-activated SGK1 involvement in negative regulation of TLR-4-mediated apoptosis and pro-inflammatory TH1 immune responses at the feto-maternal interface SGK1 FOXO1 PRL TLR4 BCL2 IRF4 PMC6721316__F1 Protein functional interactome network for differentially expressed proteins identified in Pancreatic ductal adenocarcinoma (PDAC) tissue; down-regulated proteins (A) and up-regulated proteins (B) TES HEL107 ARPC4 RPLP0 RPSA APOE CTRC TBCA HEXB HEL-S-20 tmp_locus_29 STOM PLEC PRELP AHNAK HLA-C PSAP SND1 PMC6779857__F1 The core components of the Hippo signaling pathway LATS1 LATS2 PMC4956504__F1 Androgen pathway and genes involved in androgen biosynthesis and metabolism HSD17B3 HSD3B1 HSD17B2 PMC4907806__F3 Exercise-Driven Metabolic Pathways in Healthy Cartilage TEC BAD MAK HEL-S-69p PMC9040077__F1 Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease IFNG FAS TRADD FADD PMC8451139__F8 New Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling BAX BAD FAS MFN2 FADD PMC6776190__F9 Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs RBX1 SMAD1 THBS1 SMURF1 SP1 E2F4 SMAD2 SMAD6 SMAD4 SKP1 SMURF2 TGFBR1 PMC11354542__F6 Neurotrophin-signaling pathways in the high-intensity exercise group (blue: downregulation) SHE DAO PMC6776190__F7 Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs APC LRP5 LRP6 CTNNB1 PMC11783322__F6 Protein-protein interaction (PPI) analysis (A) PPI network analyzed through STRING web site (www HEL-68 MAPK14 NCK1 WAS ARHA KRAS MAPK3 PMC9204593__F2 Transient Receptor Potential Channels, Natriuretic Peptides, and Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure PGC HEL-S-11 CNP PMC6357062__F1 Intracellular negative immune regulators of dendritic cells (DCs) SOCS1 STAT3 FOXO3A RELA SOCS3 PMC5564223__F1 The influence of Notch and Wnt pathways in the oncogenesis and stemness maintenance of breast cancer cells in the absence of estrogen NUMB FOXA2 CCND1 PMC4957033__F5 Top network of THC-regulated miRNAs KLF4 CDKN2A CCNE1 NFATC2 BRCA1 SMAD2 SOCS2 IRF4 BDNF SSB TWEAK CDK4 PMC11173095__F3 VEGF signaling pathway SHB FRS2 FRK GSK3B GRB2 MTOR SRC PMC4762491__F2 Man-P-Dol acts as mannosyl donor for the synthesis of M9-DLO, GPI anchors, and C- and O-mannosylated proteins SRD5A3 DPM2 DPM1 ALG3 DPM3 PMC4795779__F1 Involvement of Endoplasmic Reticulum Stress in TULP1 Induced Retinal Degeneration ATF4 EIF2A XBP1 PMC2958833__F2 Nutritional Programming in the Rat Is Linked to Long-Lasting Changes in Nutrient Sensing and Energy Homeostasis in the Hypothalamus RHEB TSC2 RICTOR NR1C1 TSC1 RXRA GSK3B GRB2 BDNF RORA PMC8919014__F3 Inflammatory bowel disease-related colorectal cancer: Past, present and future perspectives STAT3 APC AXIN1 MYC CTNNB1 PMC5337497__F3 Schematic presentation of the tricarboxylic acid cycle (TCA) pathway and amino acid biosynthesis, as affected by the chlorotic mutation ACLY NAGS DLAT ASL DLD CS CIT PMC6397842__F2 Schematic overview of bone cells and extracellular matrix components involved in regulating bone homeostasis SOST DKK1 SPARC PMC3894810__F5 New insights into host–pathogen interactions during Entamoeba histolytica liver infection CP PMC6366073__F5 Euglena gracilis has flexible and fault-tolerant mitochondrial metabolism ISCU AFP C2 FES PMC2671802__F1 ALPS and CEDS illustrate signaling pathways for lymphocyte apoptosis and activation FAS BCL10 NRAS FADD PMC6046065__F1 Pharmacological modulation of mitochondrial calcium homeostasis MICU1 DLD MCU MCUB EFHA1 PMC5247608__F7 Model depicting roles of Sufu in chaperoning Gli functions during Shh signaling SIN3A KIF7 SAP18 SUFU PTCH1 SHH SMO GLI3 PMC8034539__F1 B3-adrenergic signaling pathway that promotes thermogenesis in adipocytes TFAM UCP1 IRF4 NRF1 PMC9251357__F2 Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites NINJ1 GSDMD NLRP3 IL1B PMC8034539__F2 Schematic models of BMP7 and TGFB signaling pathways in thermogenesis SMAD1 DKFZp781O1323 COX2 SMAD2 BMP7 WNT10A PMC3950821__F3 Leveraging melanocortin pathways to treat glomerular diseases CDC42 GSK3B RHO SRC IL1B PMC3091524__F3 Role of ATR- or ATM-dependent modulation of WRN function in promoting correct recovery from replication arrest TOPBP1 ATR ATRIP RAD51 WRN ATM PMC2169053__F6 Model for SCF-mediated regulation of hFBH1 and Srs2 turnover in response to DNA damage RAD18 PCNA SKP1 FBXO18 PMC9277879__F2 Gut–liver axis in sepsis: interaction mechanisms and therapeutic potential TLR4 IL6 LBP MYD88 PMC3372318__F3 The two major signaling cascades operating in cancer, following overactivation of the INSR/IGF-IR signaling pathways RHEB INSR MTOR PMC9110832__F1 Involvement of Caspases in Neuroinflammation and Neuronal Apoptosis in Chronic Pain and Potential Therapeutic Targets CXCR3 CCL21 TRPV1 TNF IL1B PMC6558407__F5 Insulin and autophagy signaling modulation in Huntington’s disease (HD) IGF1 ATG12 ATG5 IRS1 PMC7144527__F8 Schematic model for RNF125 and Cbl-b in LPS-induced endotoxemia GSDMD RNF125 NLRP3 CASP5 CASP4 TLR4 IL1B MYD88 PMC3638063__F1 MTOR signaling pathway RHEB MLST8 TSC2 RICTOR GRB10 TSC1 SGK1 PTEN MTOR DEPTOR EIF4E PMC7046304__F8 SPAG5‐AS1/miR‐769‐5p/YY1‐positive feedback loop transcriptionally induced SPAG5 and SPAG5‐AS1 interacted with USP14 to induce de‐ubiquitination of SPAG5, so that AKT/mTOR signalling was activated to inhibit autophagy and induce apoptosis in podocytes USP14 SPAG5 YY1 MTOR PMC4971466__F4 Dynamic mRNA and miRNA expression analysis in response to intermuscular bone development of blunt snout bream (Megalobrama amblycephala) IFNG SMAD1 SMURF1 SMAD4 SKP1 ARHA SMURF2 PMC8460909__F7 Myeloid-Derived Suppressor Cells Alleviate Renal Fibrosis Progression via Regulation of CCL5-CCR5 Axis CCR5 SMAD2 CCL5 PMC7959294__F10 Schematic diagram illustrating the potential targets of HSR2104 to inhibit inflammatory responses and cell migration in BV2 cells TLR4 MYD88 PMC8964740__F2 Main mechanisms of miR-31 in oral squamous cell carcinoma (OSCC) WLS SIRT3 LATS2 EGFR NUMB ARHA PMC8215340__F1 Metformin, Macrophage Dysfunction and Atherosclerosis NCEH1 ABCG1 ACAT1 NLRP3 CD36 UNC5B TLR4 CCR7 CCL5 CCL2 TNF ABCA1 PMC6719526__F4 Metabolic reconstruction of the isolated strains Halonotius terrestris sp RFWD2 COBL PMC5766142__F6 Methylene-tetrahydrofolate reductase contributes to allergic airway disease TRIO MAPK11 STAG3 STAC3 MYL10 ASB4 RNF31 EPHB6 MC4R OPRM1 RPL13 OSBP GPR132 MLF2 IL9R NFKBIE PMC6558407__F2 PI3K-AKT-mTOR signaling and Metformin targets RHEB TSC2 TSC1 IGF1 IRS1 PMC9665039__F3 Signalling by TNFR1 and overview of the three characterized cell death checkpoints in the TNFR1 pathway SHARPIN RIPK3 GSDMD TRADD MLKL TANK RIPK1 TNF FADD PMC7583940__F1 Canonical pathway of microRNA (miRNA) biogenesis AGO4 DGCR8 AGO1 AGO2 DROSHA PMC8985609__F2 Activation of the non-canonical NLRP3 inflammasome NLRP3 TLR4 IL1B PMC9735758__F3 IL-1RAP, a Key Therapeutic Target in Cancer TAB3 IL33 IRAK1 IL36A IRAK2 IL36B TRAF6 IRAK4 MYD88 MAP3K7IP1 PDPK1 GAB2 IL1B PMC7923182__F11 Scheme of reactions proposed for Rho pathway modelling WNT5B ARHA DAAM1 PMC8466454__F7 Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling KEAP1 MAF GPR49 PMC6944231__F5 Presynaptic proteins that were altered in AD NAPA FYN VAMP2 PCLO UNC13C CLTC PMC5360511__F5 PPARG targeted oral cancer treatment and additional utility of genomics analytic techniques MADD GP9 CAV2 CD24 FLI1 CD36 PMC6944231__F3 Pathway analyses of significantly altered proteins by IPA GNAI3 GNAO1 RIMS3 VAMP2 KEAP1 SNAP29 FARP1 GNG3 SLC12A2 KCNA2 VSNL1 RALA CHGB NFE2L2 RAB3D DCTN3 SNAP25 SYT1 PMC4148307__F8 Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation GNA11 MTOR PMC11106741__F2 Esc, a compound with potential anticancer properties, promotes apoptosis and inhibits the proliferation of tumor cells STAT3 SP1 IGF1 KEAP1 MTOR JAK1 CCND1 CTNNB1 PMC11106741__F1 Esc in cancer cells was revealed to be related to apoptosis, which is governed by the mitochondrial pathway, ER stress and ferritinophagy FTH1 SP1 GPX4 NFE2L2 SP2 XBP1 PMC3891875__F1 Wnt signaling APC LRP5 LRP6 RHO NLK RUNX2 CTNNB1 PMC6471465__F6 Signaling pathway involved in intact or papain-hydrolyzed glycomacropeptide modulation on RAW 264.7 macrophage response to lipopolysaccharide or hydrogen peroxide KEAP1 TLR4 MYD88 PMC7017369__F7 Signaling cascades of RA-mediated repression of B3GALT5-LTR promoter activity that reduce SSEA3 synthesis in human ES cells STAT3 B3GALT5 SIRT1 PMC8415231__F2 Targeting the Wnt/Beta-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis DKK1 APC MAF SFRP1 WIF1 CTNNB1 PMC2833197__F7 Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway ATF4 VEGFA XBP1 PMC2579774__F4 HIV-1 infected astrocytes and the microglial proteome GM2A EGR1 PIG59 ZNF148 ENO1 CNBP RPLP2 PMC8124582__F2 Posttranslational Modification of Waxy to Genetically Improve Starch Quality in Rice Grain UTP4 PGM2 FBP1 PMC548008__F7 The molecular mechanisms involved in the TGF-Beta-Smad7 signaling pathway resulting in activation of Akt and p38, followed by phosphorylation and inactivation of GSK-3B GSK3B CTNNB1 PMC4684418__F1 Targeting Pink1-Parkin-Mediated Mitophagy for Treating Liver Injury USP30 PINK1 USP15 BAG4 SIAH3 PMC7353140__F1 Features of the nuclear envelope and ER and regulation of and functions for lipid asymmetry at the inner nuclear membrane (INM) NUP133 CTDNEP1 PC PMC8524782__F2 Molecular Mechanisms of Hepatoblastoma GREB1 HGF PIG59 APC LECT2 GSK3B AXIN1 LRP5 GPR49 CTNNB1 PMC8240219__F9 Tanshinone I exerts cardiovascular protective effects in vivo and in vitro through inhibiting necroptosis via Akt/Nrf2 signaling pathway KEAP1 MLKL MAF PMC8348825__F1 Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta LEP IGF1R GRB2 INS TBC1D4 IRS1 IL1B PMC2699361__F1 The ER–mitochondria apoptotic signalling pathway operating in cells devoid of mitochondrial BAK and BAX, and of ER-located BAX BAX BAD TRAF2 PMC8348825__F2 Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta TG PRL BCL6 PMC4236175__F1 Examining the Polymorphisms in the Hypoxia Pathway Genes in Relation to Outcome in Colorectal Cancer CXCL12 HIF3A LOX HIF1A MIF PMC6801506__F3 The most significant Ingenuity Pathway Analysis (IPA) network of differentially regulated proteins in the MHO group compared to those from the MUHO group KRT10 ANAPC7 AMBP NRAS UNK PMC9279723__F1 Autophagy in Bone Remodeling: A Regulator of Oxidative Stress FOXO3A TFEB MTOR PMC3789264__F8 Brain site-specific proteome changes in aging-related dementia GNB1 UBC CDK5 CEND1 CLU GSK3B APP AHNAK TNR PMC3049118__F3 Endocrine system development and function genes increase in the spleen of CVB3 infected males at 12 h pi HTRA2 FKBP4 BIRC5 TCF7L2 STK11 SPARCL1 DNAJB4 DNAJA4 MSR1 CHEK1 PMC2902124__F1 TLR signalling TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 TLR7 TRAF6 MYD88 PMC3789264__F7 Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) cerebellum (Cb) ACOT7 HEL113 ZFYVE28 MBP HEL-S-162eP PXK SCAMP3 SLC18A3 CCDC50 SPCS2 AHNAK TUBB PMC3789264__F6 Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) parietal cortex (pCx) HEL113 ATPAF1 HMGN5 MSTO1 ANXA6 ZNF358 TMEM131 SCRN1 EP300 PMC3169997__F1 Epithelial cell cycle arrest in G2/M and epigenetic changes in fibroblasts coordinately promote kidney fibrosis RASAL1 ADA PMC3789264__F5 Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) hippocampus (Hp) ALB TMCO3 CEND1 MBP INA HEL-S-162eP MARCKS AHNAK PMC3277752__F2 Browsing the ApoptoProteomics database BAD FADD PMC9148284__F1 Cellular and Molecular Events Leading to Paraquat-Induced Apoptosis: Mechanistic Insights into Parkinson’s Disease Pathophysiology HTRA2 BAX KEAP1 EIF2A PMC8509056__F6 Molecular and Metabolic Insights into Anthocyanin Biosynthesis for Leaf Color Change in Chokecherry (Padus virginiana) MAX MYB PRL PMC8387351__F1 Stress response pathways dysregulated with age and injury: ATF4 PMC5177517__F6 Proposed model for the mechanism of SNRK regulation of ROCK activity SNRK PTEN RHO PMC3049118__F6 Cardiovascular disease genes increase in the spleen of CVB3 infected males at 12 h pi LPL CXCL12 CA3 FRZB BAG2 HPR CCR4 HEL-S-11 PLA2G12A NCKAP1 MAP2K3 PMC2654353__F5 From nutrients to HIF and from HIF to metabolism TSC2 TSC1 HEL-S-133P HEL-S-68p HK2 MTOR PMC2654353__F7 From the extracellular matrix to HIF and from HIF to the extracellular matrix LOXL2 LOX MTOR CXCR4 PMC5007661__F3 Potential impact of bone tissue engineering in the clinic BAX BAD APC SUN1 SRC FOS PMC3229969__F2 Roles of FGF signaling in stem cell self-renewal, senescence and aging FRS2 MDM2 GRB2 PMC4490940__F10 Possible pathways of Cd-induced MAPK/ERK signaling HBEGF CD2 EGFR GRB2 SRC GAB2 PMC1991338__F1 ZIP1 expression and zinc accumulation in the pathway and bioenergetics of citrate production and citrate oxidation in normal versus malignant prostate cells MAL CS CIT PMC7019052__F3 Skeletal muscle gene expression in Hereford and Holstein-Friesian vs Limousin visualized on the p38 MAPK signaling SHC1 TRADD HMGN1 RAC1 MEF2D MAPK14 STAT1 MAP2K6 HEL-S-102 DDIT3 RIPK1 GRB2 RPS6KA5 TRAF2 PMC4628569__F3 IL-27-induced modulation of autoimmunity and its therapeutic potential STAT3 STAT1 IL10 AHR SOCS3 FOXP3 JAK1 EGR2 TYK2 GATA3 PMC4706927__F5 Putative inhibitory pathway of macrophage-mediated inflammatory signaling responses, as suppressed by KTH-13-AD1 TLR4 SRC MYD88 PMC7602422__F1 Aryl-hydrocarbon Receptor (AhR) Signaling Pathway in Osteoclasts CYP1A2 SYK AHR NFATC1 PMC7757040__F2 Diagrammatic illustration of the mechanism by H2S donors in regulating autophagy and cell migration CDH2 TIMP3 SP1 LIMK1 MTOR ATG5 CTNNB1 PMC6697704__F1 Main molecular interactions implemented in the model HGF PMC3987972__F3 Intracellular signalling pathways mediated by HLA class I or II antibody binding to endothelial cells IFNE TG NUP153 RHO EIF4A1 DDX3X PMC7019052__F4 Skeletal muscle gene expression in Hereford and Holstein-Friesian vs Limousin visualized on IL-1 signaling PIK3R2 TAB3 PIK3R1 PRKCZ ATF2 TRAF6 MAP3K14 IRAK4 PELI1 MYD88 MAP3K2 PLCG1 HSPB2-C11orf52 MAP2K6 MAP2K4 CHUK MAP2K3 IL1B ECSIT JUN PTPN11 UBE2V1 MAP3K1 NFKB1 IKBKB MAP2K2 REL NFKBIB PMC6965011__F2 Proposed model depicting regulation and role of METTL3 and FTO in BMSC adipogenesis and osteogenesis with regard to osteoporosis PPARG GDF11 FABP4 PTH JAK1 PTH1R RUNX2 PMC5335607__F3 Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons TF POR CD44 PC ARHA PMC7278761__F3 Schematic presentation of interactions between nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-kappa B (NFKB) transcription factors TH IL6 PMC7433199__F3 Signaling pathways other mucins involved in non-small cell lung cancer STAT3 MUC5AC PCNA EGFR MUC2 PRDM16 GSK3B MMP2 SPDEF MUC4 MMP9 CCND1 PMC6386916__F7 EtOAc extract of L MC1R DCT PMC6958341__F5 Overview of the metabolic pathway changes in murine 3T3-L1 adipocytes due to insulin or TNFA treatments FAS COX7A1 NDUFS8 COXFA4 NDUFAF2 NDUFB10 HSPD1 UQCRB COX2 HEL-S-5 LIPE ROMO1 HEL-S-44 PMC3357552__F7 TLR4 signaling in alcoholic steatohepatitis and fibrosis IFNG COL1A1 TGFB1 TLR3 CCL3 TLR4 SMAD2 IRF3 CCL4 CCL5 MYD88 TGFBR1 PMC8851315__F1 Mitochondrial-Derived Peptides in Diabetes and Its Complications STAT3 BAX CNTFR PMC11392669__F10 Tumoral VISTA facilitation of the proliferation of CML cells and suppression of apoptosis CRK BAD CRKL BCL2 GRB2 MTOR GAB2 PMC8195260__F2 Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease STAT3 EIF4B BAD PXN PLD2 MTOR RHO EIF4E RHEB TSC2 TSC1 INSR ELF3 PMC4077663__F2 Leptin–brain melanocortin system interaction INA POMC MC4R PMC3164457__F5 Mi-2/NuRD complex depletion in germinal center B cells leads to alterations in chromatin, checkpoint activation, and delayed progression through S phase CHD4 RAD51 CDC45 CDK2 ATM SETDB1 CCNB1 PMC5727169__F5 Pathway analysis using WikiPathways revealed that the factors related to the calcium signalling pathway (Kelder, T., Chichester, C., Hanspers, K.: Calcium Regulation in the Cardiac Cell (Danio rerio) SPN PKIG ADRB2 RGS4 RGS1 YWHAZ YWHAG PMC3357552__F1 Overview of TLR signaling TBK1 TIRAP TLR9 IRAK1 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC2955995__F1 Targeting Notch signaling pathway to overcome drug-resistance for cancer therapy NOTCH2 NOTCH3 NOTCH1 PMC5544253__F4 BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure BAX JUN TGFB1 HEL-S-273 ACKR2 LITAF PHGDH RELA B3GALT2 CEBPB Nucb2 GPR64 PMC6582499__F8 Schematic diagram illustrate the potential mechanisms of VPA and gemcitabine on pancreatic cancer cells BMI1 STAT3 GEM PMC10883245__F8 DOCK7 in EVs mediates intercellular communication between TAMs and CRC cells DOCK7 FOXO1 ABCA1 PMC6814379__F1 Glucose metabolism, energy production, and its importance in DNA replication and epigenetic homeostasis PHGDH GC PSPH PMC4806302__F6 Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway SAG SHH SMO PMC11642109__F1 Schematic illustration showing the effects of the sympathetic nervous system (SNS) and the renin–angiotensin system (RAS) on cancer development STAT3 GATA1 RAP1A MTOR ACE2 PMC8391894__F2 DNA Polymerase θ: A Cancer Drug Target with Reverse Transcriptase Activity RAD51 DNA2 BRCA1 POLE PMC5689469__F6 Proposed mechanism of muscle immaturity in CDM STAT3 CTCF DMPK PMC2756021__F3 Neuroprotective Effects of the Complement Terminal Pathway During Demyelination: Implications for Oligodendrocyte Survival BAX BAD FAS PMC5995803__F8 Multiscale networks identified within neurons contain neuron-specific modules PPP1R12B KIF3A CD59 SYNGR3 WASF3 SRP14 GSK3B HECW2 RGS7 NME4 RNF115 TMEM130 NF1 PDPK1 IFT81 USP24 BMPR2 DIS3L2 NAPB ACVR2A CAPZA2 MRPS28 GRIK1 DNAJC18 ALDH3A2 OSBPL6 NR2F1 RPL19 AASDHPPT POLR3E USP3 DPM1 HLF PHF10 BRD2 LDOC1 STAG2 BICD1 FGF13 ASB8 SH3GLB1 TMEM151A LRP11 C1orf52 TBC1D30 MTOR KPNA6 BAALC EPHA7 MCF2L2 NDUFS4 CLCC1 GOLGA7 COX7A2L FAXC CNIH BLOC1S2 PRKCE BRD10 GGA2 DENND4A ARHGEF12 MRPL22 MEGF9 SSU72 ZNFX1 DNER ZNF385B RBM23 PPP1R9A HDAC6 RPS6 KMT2C RPLP0 PTBP3 KIDINS220 EEF1B2 CMPK1 RAC1 PFDN4 NFIA SAT2 DKK3 ZRANB2 SLC2A13 IPO5 SPTBN4 NFKBIA SRSF4 IL6ST NDUFA2 SMDT1 CRIM1 BCL6 PMC7172983__F1 CGAS-STING pathway of cytosolic DNA sensing TBK1 STAT1 CGAS STAT2 ATG9A ULK1 WIPI2 NLRC3 IRF3 JAK1 TYK2 PMC8058381__F7 Fubaiju protected ARPE-19 cells oxidative damage by activating PI3K/Akt mediated Nrf2/HO-1 signaling pathway BAX NQO1 GCLC PMC3524627__F8 Model depicting the regulation of DNA damage-induced germ cell apoptosis by C SGK1 PMC9448988__F2 Lung cancer in never smokers: Tumor immunology and challenges for immunotherapy IFNG EGFR TNF CXCL8 PMC8692584__F1 E3 Ubiquitin Ligases and Deubiquitinases in Inflammatory Bowel Disease: Friend or Foe? LTBR RELB TAB3 IRF3 USP9X TNF TRIM21 MYD88 CAP2 RNF183 RIPK2 MAP3K7IP1 TRIM28 TLR4 RELA NOD2 RIPK1 NOD1 TRIM58 REL CAP1 TRAF2 CYLD USP16 PMC10178682__F1 Simplified picture of cancer metabolism GOT2 FH GLS HK2 GPT2 CS SLC7A5 PMC8741373__F11 Identification of Potential Biomarkers of Depression and Network Pharmacology Approach to Investigate the Mechanism of Key Genes and Therapeutic Traditional Chinese Medicine in the Treatment of Depression MGA MAK TRAF3 PMC10094755__F6 Metabolic pathway of 17Beta-estradiol biosynthesis HSD3B2 STAR CYP11A1 HSD3B1 HSD17B1 HSD17B2 PMC10539668__F8 TNFA counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes STAT3 LYN SOCS3 JAK1 TYK2 PMC9331798__F7 Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage TNFSF11 MTOR IL1B PMC5689582__F3 Increased transcriptional and metabolic capacity for lipid metabolism in the peripheral zone of the prostate may underpin its increased susceptibility to cancer CYP2R1 CYP51A1 CYP24A1 EBP MSMO1 SQLE SC5D DHCR24 SOAT1 DHCR7 FDFT1 TM7SF2 PMC11833111__F5 Correlation analysis of differential microbiota, metabolites, proteins and FST PNPLA7 FST LPCAT1 ENPP2 PMC8535226__F2 Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn’s Disease LTBP1 SMAD1 THBS1 DKFZp781O1323 SP1 SMAD2 SMAD6 SMAD4 NODAL ARHA PITX2 TGFBR1 BAMBI IFNG RBX1 SMURF1 E2F4 FST ROCK1 SKP1 SMURF2 PMC7830467__F1 Ubiquitin signaling in the tumor microenvironment (TME) MMP2 PMC4472614__F4 Functional relations of differentially expressed genes with each other and with members of important pathways, as displayed by FunCoup online resource SPN JUP EMP1 HELLS DAG1 FER RCC2 NR1C2 AKAP12 NKTR FOS LMNA PMC4451739__F2 Complement during infection with a pathogen C6 C7 HEL-S-62p C9 C4B_2 PMC3042730__F2 Inflammatory signals regulate hematopoietic stem cells CSA2 IFNGR1 TRADD STAT2 IRF9 ATF2 TRAF6 MYD88 IFNG STAT1 IFNGR2 IFNAR2 IFNAR1 JAK1 TRAF2 TYK2 PMC11885647__F6 Stem cell exhaustion and intercellular communication regulated by redox signaling LATS1 FYN KEAP1 AMOT SMAD2 PTCH1 SMAD4 SHH SMO RHO NF2 CTNNB1 PMC11885647__F5 Redox signaling modulates metabolic reprogramming MICU1 TSC1 MCU PTEN EFHA1 KRAS IRS1 PMC11885647__F4 Redox regulation of proteolysis FAT10 PTMS ATE1 PMC4793894__F3 PPAR signaling pathway PPARG CD36 FABP1 UCP1 NR1C2 FADS2 PCK1 ACADM SLC27A5 OLR1 CYP7A1 PDPK1 PLIN1 CPT2 APOA5 CYP27A1 LPL APOC3 ACOX1 UBC NR1H3 CYP8B1 SCD HEL-S-28 FABP4 ME1 APOA2 NR1C1 ACSL1 ANGPTL4 AQP7 DBI RXRA ACADL PLTP SLC27A4 PMC7037237__F1 Simplified schematic of type-I IFN induction and major IFNAR signaling pathways CGAS IRF9 TLR9 IRF1 IRF3 IRF7 TNF IRAK4 MYD88 STAT1 TLR3 IFNAR2 TLR4 IFNAR1 TLR8 TLR7 TYK2 PMC6814307__F1 Vitamin D metabolic pathway CYP2R1 CYP27B1 CYP24A1 PTH FGF23 PMC8635790__F5 Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease SLC11A2 ACSL6 SLC40A1 FTL FACL4 SEPHS2 PMC3481284__F8 Schematic diagram of CaMKII regulates Notch1 signaling through proteasomal degradation of SMRT HES1 NOTCH1 HES5 PMC6953115__F2 Epac1 signalosome in cardiac stress conditions HDAC5 TRPC3 PMC6780103__F4 Human adenovirus induced cell signaling and downstream immune responses in human keratocytes, highlighting the centrality of Src kinase TLR1 TLR9 CD46 SRC MYD88 PMC3230686__F3 Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27 STAT3 STAT1 RORC RUNX1 MAF AHR FOXP3 PMC5927979__F2 Interaction network of microRNAs identified potential mRNA targets involved in clinical features of antiphospholipid syndrome ANKRD29 PTPRM BMPR2 HIVEP1 SCNN1G AXL PARVA RASL12 SAMD12 NR1C2 VEGFA CCL2 BPTF CD47 LAMP2 SBF2 INSR E2F3 EDNRB DGKE DOCK4 NNT PMC8825490__F1 Macrophage Immunometabolism: A New Approach to Fight Infections SLC3A2 FAS FH ACO2 OGDH HEL-S-133P HEL-S-68p HEL-S-162eP HEL-S-30 PMC8245300__F5 ATRX-dependent mechanisms in physiology, cancer and human genetic disease REST MACROH2A1 PMC4225461__F1 Statistically significant signaling pathway networks between JU and vehicle groups WRNIP1 CEACAM1 ANXA3 FOSB CGA RNASEL DUSP4 DNAJC2 ATF3 CCNG1 AGTR2 PSENEN RORC CYB SPRED1 ANGPTL3 HCST APH1B APBA3 SERPINB2 AMH PTGFR CP PMC8216565__F8 PI3K-AKT signaling pathway RHEB SYK TSC2 EIF4B BAD MEI1 RBL2 CD19 PTEN MDM2 GRB2 REL PMC4424001__F2 Hierarchical Feedback Modules and Reaction Hubs in Cell Signaling Networks EGFR PLCB3 SHE PMC8216565__F9 MAPK signaling pathway MAX FAS ELL APMAP CD14 APP NLK PROC FLNA TRAF2 PMC3879958__F1 Regulating the Regulator: Post-Translational Modification of Ras RAF1 TIAM1 NF1 RIN1 PMC2671025__F6 Role of adiponectin in human skeletal muscle bioenergetics ADIPOR1 ADIPOR2 MEF2C PMC4023229__F2 Neural tube defects – recent advances, unsolved questions and controversies SFRP5 SMURF1 VANGL1 CTHRC1 PTK7 ARHA SMURF2 SFRP1 PMC11375541__F10 Dual functionality of necroptosis in CC patients CXCL9 CXCL11 CD3D CXCL13 VEGFA CXCL10 PMC2696553__F1 Store-operated Ca2+ entry in T cells ORAI1 LAT FOXP3 LCK PMC7411728__F2 Inflammation, innate immunity, and adaptive immunity by CH25H and 25HC IL18 CH25H TNF IL1B PMC8650046__F3 Circular RNA‐associated ceRNA network involved in HIF‐1 signalling in triple‐negative breast cancer: circ_0047303 as a potential key regulator STAT3 TIMP1 PIK3R3 EGFR AKT3 RPS6KB2 PIK3R1 HIF1A EGLN3 HMOX1 IFNGR2 TFRC PLCG1 INSR TLR4 PRKCA FLT1 MAPK1 IFNGR1 PFKFB4 HEL-S-133P HK2 VEGFA IL6 ANGPT2 VHL EIF4E CDKN1A HEL-S-68p NFKB1 CDKN1B RELA CREBBP BCL2 EP300 HEL-S-87p PMC9099016__F3 LncRNAs and CircRNAs in cancer CCND2 FOXP2 PMC6678715__F3 FGFR signaling pathway CRK FRS2 GRB2 DOCK1 PMC2910728__F6 Absence of Inhibin Alpha and Retinoblastoma Protein Leads to Early Sertoli Cell Dysfunction CDKN2A CCND2 ACVR1 BBC3 FSHR CCND1 APAF1 CDK4 PMC7538694__F7 BMP signaling pathway in mouse and zebrafish SMAD1 DKFZp781O1323 SMAD4 ID1 PMC7145763__F5 Human BNB junction complex formation: The GDNF-CREB1-SRC-CTTN/CTNNA1/CLDN4-SEC31A hypothesis SEC31A GDNF SRC CTNNA1 CREB1 RET PMC9101234__F6 Cardiac Fibroblast GLS1 Expression by Scleraxis GLS GPT PMC8584118__F2A Nod-like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections NLRP12 RELB IRAK1 TRAF3 TRAF6 MYD88 PMC9299562__F3 Integrated bioinformatics analysis of validated and circulating miRNAs in ovarian cancer POR tmp_locus_29 PMC4899597__F1 Canonical Wnt signalling involves binding of Wnt to LRP5/6 and its coreceptor Frizzled resulting in the phosphorylation of LRP5/6 thus permitting Axin to bind to the receptor complex LRP5 LRP6 TEF CTNNB1 PMC8013908__F1 COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options TMPRSS2 TBK1 NRP1 CTSL IRAK1 IRF3 IRF7 TRAF3 FURIN TRAF6 IRAK4 MYD88 TLR3 TLR4 TLR7 HDAC2 ACE2 IL1B PMC3774073__F1 Phosphorylation events and the modulation of aquaporin 2 cell surface expression SNAP23 AQP2 MAL GC PMC9405025__F3 Yeast Beta-Glucans as Fish Immunomodulators: A Review SYK APOA4 PS1TP5BP1 IL1B MYD88 PMC2981507__F2 Therapeutic interventions for fragile X syndrome RHEB TSC2 TSC1 MTOR EIF4E PMC3176306__F1 New strategies in Prostate Cancer: targeting lipogenic pathways and the energy sensor AMPK ACLY RHEB TSC2 TSC1 FASN HEL-S-5 MTOR EIF4E PMC3075259__F4 Data Integration Workflow for Search of Disease Driving Genes and Genetic Variants MDM4 CDKN2A MDM2 CCNB1 MTR PMC8497523__F7 Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways NME3 PAICS PGM2 AMPD3 ADK CMPK1 IMPDH2 PDE4D NUDT5 PFAS PMC5569249__F1 miRNA pathways in myeloid differentiation and myeloid-derived malignancies BTG2 TPO PTEN MTOR PMC5660697__F1 JNK signaling pathway TH HMGB1 ATF2 PMC5082882__F1 Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERA in Breast Cancer Cells ELOVL2 FADS2 ELOVL5 FADS1 PMC5569249__F2 miRNA pathways in mature immune cell function SOCS1 IRAK1 IRAK2 IL1B MYD88 PMC9139060__F2 Low-Grade Inflammation in the Pathogenesis of Osteoarthritis: Cellular and Molecular Mechanisms and Strategies for Future Therapeutic Intervention HMGB1 FLI1 NLRP3 TRAF6 MYD88 PMC9124082__F7 Marine-Derived Stichloroside C2 Inhibits Epithelial–Mesenchymal Transition and Induces Apoptosis through the Mitogen-Activated Protein Kinase Signalling Pathway in Triple-Negative Breast Cancer Cells CDC2 BAX C2 CDK2 CCNB1 PMC3995458__F1 Biosynthetic pathways of glycerophospholipids LPA PGP LPGAT1 LPCAT2 LPCAT3 PC LPCAT1 PMC5395355__F2 Phosphopeptides from the MOE and FOE phosphoproteomes are represented in some distinct signaling pathways, including Rho signaling for MOE (A), GABA signaling for FOE (B) and amyloid processing for FOE (C) GABARAP EZR GPHN APP HEL70 RHO RDX CP PMC5661483__F12 10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NFKB and (BIRC6-XIAP) complexes BAX BIRC6 FAS TRADD BAG1 CYCS IGF1R TNF NAIP BIRC5 DFFA GADD45A BIRC2 DIABLO FADD BIRC3 PMC7828503__F3 Signaling lymphocytic activation molecule family receptor (SLAMF) 3 signal transduction is mediated via self-ligation and cell–cell interactions TF FYN C2 APC GRB2 PMC3312283__F2 This figure shows three novel intracellular signaling pathways involved in the pathogenesis of IBD STAT3 VCAM1 IL1B PMC7102672__F6 Enriched DGEs in the p53 signaling pathway The DGSs included in the CG vs HS groups, and CG vs HR groups are shown CASP9 TSC2 ATR BAD SIAH1 PERP CASP3 CDK2 ATM PTEN MDM2 PMC7102672__F5 Enriched DGEs in the PPAR signaling pathway There were three pairwise comparison groups (CG vs HS, CG vs HR and HS vs HR) in our study, and there were three kinds of DEGs from the different comparison groups LPL UBC AQP7 UCP1 HEL-S-28 PLTP APC2 PMC12191391__F4 TR2/TR4-mediated regulatory pathway in heme biosynthesis GATA1 ALAS1 ALAS2 PMC3905307__F1 Canonical (A) and noncanonical (B) Wnt signaling pathway represented by KEGG analysis CHP2 PLCB4 NFATC2 CHD8 FBXW11 PPP2CA PPP3CA RAC3 BTRC SENP2 DKK2 CCND1 MMP7 JUN SIAH1 TBL1X APC ARHA PPP3R2 SFRP1 PRKACG DVL3 SKP1 NLK CAMK2G WIF1 DAAM1 PMC8435845__F3 Research Progress on the Structure and Function of G3BP IFNE GAL MMP2 PTEN TNF SPP1 PMC8153896__F4 Molecular Dynamics-Based Allosteric Prediction Method to Design Key Residues in Threonine Dehydrogenase for Amino-Acid Production IVD GHB2 NR1A2 THRA PMC6562660__F2 Downstream effector proteins of the major Rho GTPases, Rac1, Cdc42, and RhoA CDC42 SSH1 ARHA RHO RAC1 PMC2815188__F2 This presentation will focus on molecular mechanisms underlying transduction of BCR signals that enforce the antigen unresponsiveness of anergic B cells DOK1 LYN CXCR4 PMC8062726__F7 Summary of the regulated pathways during DCs-T CD40 IFNE DVL1 STAT3 CD80 SYK TXNIP TLR9 IL33 TRAF3 GBP4 IFNG STAT1 GSDMD OASL CYBA SRC NOS2 IFNGR1 STAT2 IRF9 HEL-S-84 NAMPT AIM2 IRF1 IRF7 RSAD2 OAS3 TNF CXCL10 TP53BP1 CXCL11 GNA11 PLCB2 ZNF730 BDKRB2 CYBB CXCL9 ADAR TRADD MAVS CD36 FZD10 RBCK1 IFIT1 IKBKE TANK PML IFNK EIF2S1 RIPK2 HLA-F CARD16 TICAM1 TXN2 IL18 NOD2 PYDC5 RIPK1 MITA TLR7 MX1 ISG15 OAS1 IFNA1 OAS2 KNG1 GBP2 GBP3 GNAI1 IL10 IL12A RNASEL NFATC1 TLR1 TRIM25 TLR3 IL6ST JAK1 IFNB1 TYK2 FADD PMC9465172__F2 Exposure of metal toxicity in Alzheimer’s disease: An extensive review CCS GSK3B APP ATP7B COX17 ATP7A PMC8611230__F1 Melanoma susceptibility: an update on genetic and epigenetic findings CDKN2A CDK6 TERF2IP BAP1 ATM ACD POT1 CDK4 PMC8062726__F5 Protein-protein interaction underlines genes from virus response as network-hubs XRN1 CCL3 TAP1 CMPK2 DCP1A IL15RA CCL2 RTP4 TAGAP SP100 USP18 OASL MT1M MT1G MRPL17 DMXL1 PSME2 CCR1 SP140L NMI IFITM2 MRPL40 STAT2 IRF9 IFITM1 CTNNBL1 IRF7 IL1A CXCL10 SKI RNF213 CXCL11 LAP3 MT1E IFI27 CCL4 CASP10 IL15 CXCL9 FAS RBCK1 IFIT2 TRIM21 PLEK HELZ2 PARP12 ZBP1 CARD16 CASP4 IFITM3 PATL1 MX2 ZNFX1 GBP2 IL1B GBP3 CD48 SMCHD1 LCP2 PARP14 PSMB8 LGALS3BP DTX3L SP110 PTGS2 GBP1 SSB MT2A TRIM25 TLR3 PMC9735758__F1 IL-1RAP, a Key Therapeutic Target in Cancer STAT3 IL33 SIGIRR IL36A IL36B IL18RAP IL1B MYD88 PMC3381230__F2 Major mechanisms of immune modulation by tolerogenic DCs CD40 CD80 IL10 TSLP STAT4 PMC5621151__F1 TLR-signaling pathways TBK1 MAL CD14 IRAK1 IRF3 TRAF3 CCL5 TNF CXCL10 TRAF6 IRAK4 MYD88 TLR3 TLR4 PMC10526161__F1 Integrated Multi-Omics Profiling of Young Breast Cancer Patients Reveals a Correlation between Galactose Metabolism Pathway and Poor Disease-Free Survival PIK3CA PMC5930279__F1 Effects of choline in lipid metabolism pathway FAS PEMT PC PMC3681204__F3 Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines SOCS1 ALPL OSM PLSCR1 TNLG7A TAP1 SERPINB8 GBP4 MAPK14 STAT1 RTP4 ATG3 TYROBP ALOX5 OASL GCA CCR1 EIF2AK2 NMI SLPI SERPING1 STAT2 CAPZA2 HK2 AIM2 NCF4 IRF7 RSAD2 OAS3 CXCL10 FPR1 IL8RB GRB2 ADAR CSF2RA UBE2L6 RAB31 RBCK1 IFIT1 IFIT3 IFIH1 PML IFIT2 NUMB PTEN NDEL1 CR1 TRIM21 CSF3R IFI44L LTB4R ISG20 GBP5 LY96 ZBP1 CARD16 IRAK3 CEBPD IFITM3 CHUK DENND5A MX1 TAP2 ISG15 OAS1 TYMP OAS2 CEBPB GBP2 ETS2 SIRPB1 TRIM69 TLR5 GBP1 XAF1 FKBP5 GNA15 SLC15A3 NLRP12 WDFY3 GNS TNFSF10 BCL6 PMC5793162__F1 Cancer cell signaling and regulation of alternative splicing SRSF7 CASP9 SFRS3 APC GSK3B BRAF MTOR HEL-S-30 KRAS RAC1 CTNNB1 CD44 BCL2L1 PTBP1 PMC6094676__F1 Oncogene-directed small molecule inhibitors for the treatment of cutaneous melanoma BAD GSK3B BRAF RPS6KA1 KIT PTEN MTOR MDM4 NF1 NRAS BCL2 MDM2 CDK4 PMC2683622__F9 Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway PKD1 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 PMC3979852__F8 Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages TLR4 CCR8 CCL1 PMC12202659__F7 Representative molecular pathways of breast cancer induction by PCBs compound exposure MAX SYK MAFK BAD RBL2 PTEN CD19 MTOR TNF RAC1 BCR CD37 MDM2 TRAF2 PMC2773711__F1 Canonical TCR signaling pathway JUN FYN IL2 ITK REL FOS PMC6092802__F7 DNA Damage Response (DDR) Pathway HUS1 TOPBP1 RAD1 BRCA1 RAD17 CHEK2 CHEK1 MDC1 PMC6387166__F1 Effects of distinct molecules produced by stressed cancer cells on NK cell-mediated functions CGAS TLR8 TLR7 PMC1201361__F6 Anandamide as an intracellular messenger inducing Ca2+ influx via TRPV1 AMT TRPV1 FAAH PMC5996766__F1 Of Pleiotropy and Trajectories: Does the TGFB Pathway Link Childhood Asthma and COPD? NR1i1 TGFB1 SMAD2 SMAD6 TGFBR3 IRF7 TRAF6 SKI RUNX3 GLIS3 FOXH1 RARA SMURF1 RARB AHR SMURF2 SOX5 PMC4205566__F1 A Signaling Network Induced by B2 Integrin Controls the Polarization of Lytic Granulesin Cytotoxic Cells GRAP2 PARVG SOS1 PXN KLRB1 NEDD9 FLNA TEC PEAK1 ATM LPXN IL1RL2 CLTC HEL2 MAPK1 LIMS1 LCP2 NCK1 VAV3 HEL-S-28 CASS4 PTK2B USP9X SEC23B MYO1E ERAP1 c-fgr FCGR3A ARAP1 ARHGEF7 TRA2B PMC4374437__F6 Schematic diagram illustrating intracellular signaling pathways in a macrophage involved in cytokine regulation by adrenergic and cholinergic agonists and receptors following lipopolysaccharide challenge STAT3 HMGB1 PMC6608985__F15 Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFKB—IL-6 signalling axis STAT3 RAC1 IL6R PMC7555565__F3 Mechanistic network showing the highest score for a set of significantly differentially expressed genes in MG (methylglyoxal)-treated rats RGS2 DUSP10 TP53INP1 NR1D1 ATF2 IRS1 PDK4 NDUFB4 ATF7 ZEB2 CISH PDE8A HBB TBC1D4 PMC4887618__F5 The working model of STAT3 and AvrA interaction in chronic intestinal Salmonella infected in colon cancer MMP7 STAT3 IL6 CCND1 CTNNB1 PMC7555565__F5 Adverse Effects of Methylglyoxal on Transcriptome and Metabolic Changes in Visceral Adipose Tissue in a Prediabetic Rat Model DUSP8 ATF2 GRB2 IRS1 PMC3818842__F6 Major apoptotic pathways in SGNs induced by oubain treatment BAX TNF FADD PMC7865314__F4 Optimising radiation dose and delivery for optimal immunogenicity FAS APC TREX1 PMC8463930__F8 Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation MAX MAFK IL10 CD2 LTA TIRAP SELE CD14 TRAF3 TNF SHE TRAF6 MYD88 POR NGF COX2 TRAF2 FADD PMC9253705__F7 Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway STAT3 CTSK MMP2 NFATC1 PMC8044831__F1 Anti-inflammatory mediated effects of phytochemicals along the TLR4 signaling pathway COX2 TLR4 IRAK1 TRAF6 IRAK4 PMC6586490__F1 Mitochondrial dysfunctions in Barth syndrome PGS1 PGP PMC7500008__F2 Targets of overexpressed (a) and downregulated (b) microRNAs (N1 versus N0) among genes participating cell cycle progression and regulation (KEGG pathway hsa04110 – cell cycle) DBF4 COMP CDK7 PCNA PI3 SMAD4 CDK2 MDM2 MYT1 SKP2 MED1 PMC2733244__F2 Bridging the gap between high-throughput genetic and transcriptional data reveals cellular pathways responding to alpha-synuclein toxicity RFC4 RFC2 FAR1 RFX1 RFC3 CLN3 XBP1 PMC3061395__F10 The bifurcating parallel signal transduction pathways downstream of the IL-13R that regulate 15-LO gene expression in primary human monocytes STAT3 EGR1 IL13RA1 TYK2 PMC7580956__F4 Carbon metabolism in the plastids of E RPE PGP RPIA SUFU HEL-S-162eP FES PMC6755513__F10 Schematic chart showing the molecular pathway for Mg2+‐regulated endothelial barrier function TRPM7 MAGT1 TRPM6 PMC5103369__F6 Regulatory roles of the Arg/N-end rule pathway in autophagic flux and protein aggregate clearance SQSTM1 ATE1 HTT PMC3466494__F1 GSK3 regulates a variety of pathways involved in neurodevelopment PI3 APC CTNNB1 PMC4515826__F7 Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity PIK3CA BCOR KEAP1 CARD11 BRAF PTEN MTOR HYDIN CTNNB1 CTCF FBXW7 COL22A1 TTN HCN1 RIMS2 ATM RYR1 EPHA3 NF2 DNAH8 CUBN ZIM2 ZNF536 ZFHX3 RYR2 PKHD1 USH2A KDM5A HMCN1 ZNF804A KIT OBSCN PPP2R1A KRAS VHL NEFH PRDM9 CSMD3 MUC2 CREBBP LRP1B MUC4 FAT2 NAV3 PMC5008362__F1 Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach CERS3 CERS5 UGCG CERK SGPL1 CERS1 SGMS1 CERS2 SPHK1 SGMS2 SMPD1 SGPP2 SMPD2 CERS6 UGT8 SMPD4 NAAA SPHK2 SGPP1 PMC5721467__F9 Regulatory network elicited by nuclear translocation of syndecan-1 leading to inhibition of proliferation and survival PAX3 DOCK8 SP1 PMC6017063__F1 Therapeutic targets in the Notch signaling pathway DLL4 JAG2 DLL3 PMC7709037__F3 Merging network associated with the EGFR/ERBB2 signaling pathway by IPA-identified three networks (#1, #5, and #12 in ) MASP2 PARVA EGFR ERBB2 ROBO4 PMC7761891__F3 Effects of extracellular nutrients on mitochondria could activate the integrated stress response (ISR) pathway in cancer DELE1 OMA1 ATF4 EIF2A PMC3687803__F3 Canonical wnt signaling pathway DKK1 APC GSK3B PMC5048723__F4 Signaling pathways associated with differentially methylated candidate genes were predicted by Ingenuity Pathway Analysis™ WNT10B CHST14 TPD52 FOS PMC3934644__F1 Regulation and effectors of the mTOR signaling pathway BAD CDK2 EIF4E PMC5732234__F2 The immune deficiency (IMD) pathway in fruit fly and the TNF pathway in the mouse RELA REL TNF TRAF2 FADD PMC9396912__F2 Ferroptosis in esophageal cancer IFNG SLC3A2 STAT1 IFNGR2 IFNGR1 GPX4 SLC7A11 PMC10025411__F1 Neuroprotective effects of targeting key factors of neuronal cell death in neurodegenerative diseases: The role of ER stress, oxidative stress, and neuroinflammation BAX ATF4 TRIB3 XBP1 PMC4786079__F4 Fever and the thermal regulation of immunity: the immune system feels the heat STAT3 STAT1 PMC4040260__F2 Apoptotic cell clearance: basic biology and therapeutic potential HMGB1 SIRPA ARHA CD47 PMC3404876__F2 Identification of novel metastasis suppressor signaling pathways for breast cancer BACH1 HMGA2 CXCR4 PMC7746343__F8 ATR-CHK1 and ATM-CHK2 in the cell cycle pathway CDC2 ATR CDK2 ATM CDC25B PMC3091695__F3 Stress-induced pathways in the PVN of the hypothalamus of DBA/2J (A) and C57BL/6 (B) mice SPRY2 RGS2 EGF GNAO1 APP NFATC1 TNF PMC5732234__F1 Toll pathway in fruit fly and the Toll-like receptor (TLR) 4 pathway in the mouse IRAK1 TRAF6 IRAK4 MYD88 PMC3193452__F1 Regulated necrosis in the intestine of FADDIEC-KO mice TNF CYLD IL1B FADD MYD88 PMC6818007__F3 VEGF (vascular endothelial growth factor)‐angiogenesis signaling and cell cycle regulation pathways CDC2 ATR EGFR MTOR VEGFA MYC ITGAV NRG2 RICTOR PLCG1 CDK2 ATM KDR SRC POT1 PMC4980330__F2 Regulation of the Hippo pathway by multiple upstream signals LATS1 LPA LATS2 HMGCR AMOTL1 RHO PMC4980330__F1 The core of the Hippo signaling pathway LATS1 PMC6818007__F1 Telomere biology and damage signaling CDC2 ATR CDK2 ATM POT1 TPP1 PMC7833179__F1 Could Oral Phosphodiesterase 5 Inhibitors Have a Potential Adjuvant Role in Combating COVID-19 Infection? SIRT3 IL16 IL33 BCL2 MIP TNF XBP1 SIRT1 PMC7396774__F5 Re-analysis of 14 selected genes using KEGG pathway enrichment CDC2 DBF4 CDC20 PCNA CDC6 SMAD2 SMC3 APC SMAD4 MYT1 SKP2 ORC2 CDK6 CDK7 E2F4 CDC45 CDK2 MDM2 CDK4 PMC5647956__F1 Artemisinin biosynthetic pathway in A IPP MVP MVD MVK PMC5721467__F4 Upstream regulators and downstream biological effects predicted by Ingenuity Pathway Analysis on the proteome level RGS2 TGFB1 TRAF1 LYN CSF3 NOX4 IL13RA2 PRKG1 PMC9032679__F2 Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer BAX OPA1 MFN1 MFN2 PMC3817541__F1 Mechanism of activity-dependent transcriptional repression by MeCP2 NPAS4 BDNF PMC9580888__F4 Sphingosine‐1‐phosphate‐lyase deficiency affects glucose metabolism in a way that abets oncogenesis SPNS2 SORL1 MTOR PMC2651818__F3 Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network GPN3 GPD2 GPN2 HEL-S-68p HEL-S-49 FBP1 GPD1 PMC9570456__F2 Adenosine, Schizophrenia and Cancer: Does the Purinergic System Offer a Pathway to Treatment? NT5E ADK ADA PMC7190945__F2 VSL#3 on intestinal barrier function LPL STAT1 PMC7246584__F1 Interplay between HCV-induced oncogenic signaling pathways STAT3 CD81 EGF EGFR SOCS3 CLDN1 PMC7352559__F2A Klotho and the Treatment of Human Malignancies USP15 USP4 SMAD2 APC GSK3B SMAD4 MTOR SMURF2 IRS1 CTNNB1 PMC5394902__F2 Canonical pathway and upstream regulator effects analysis identifies inflammatory response, migration, and proliferation pathways enriched in trkB.T1 KO astrocytes PPARG ITGAM HEL-S-62p PTGS2 TNF PMC8373118__F4 Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative MAVS IRF3 IRF7 TRAF3 MYD88 PMC5877662__F3 cGMP signaling pathway PGC NPS GC PMC3687803__F1 Different layers of the epidermis, and the functions within those layers regulated by VDR and its coactivators NR1i1 ELOVL4 UGCG CD14 FLG SRC PMC7409063__F1 Extracellular vesicle (EV) biogenesis and signaling between neighboring cells RAB27A RAB35 ARHA PMC8740576__F5 HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR NCBP3 TGS1 MTOR EIF4E PMC9060113__F2 Targeting the PI3K/Akt signaling pathway in pancreatic B‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes IFNG TNF IL1B PMC11670804__F5 Visualization of GO terms and DETs connected to the development of HFs in sheep LRP4 TXNIP HOXC13 SFN SMAD4 FADS2 AFMID ACADM PRKCH ALOX15B NLRP3 SOX9 TGM3 MAML2 SMARCA4 KRT33A ROCK2 NGFR C7orf24 LDB1 ANXA1 NFATC1 KRT23 DSG4 FOS RPE NCOR2 ADAM9 ZDHHC21 DBI PLCB2 EP300 KRT27 PMC9316611__F2 Indoor Secondary Pollutants Cannot Be Ignored: Third-Hand Smoke EGF JUN RPS3 EGFR BCL2 MYC FOS PMC8643499__F7 Loss of Zic3 impairs planar cell polarity leading to abnormal left–right signaling, heart defects and neural tube defects PRICKLE2 DVL1 JUN CELSR1 CELSR2 DVL2 ARHA CELSR3 MAPK8 RAC1 ZIC3 VANGL1 DVL3 DAAM1 PMC2869400__F9 A model of Gfi-1-mediated repression of CDKN1A and other Miz-1 target genes CDKN1A MYC GFI1 PMC9323599__F3 Edwardsiella ictaluri T3SS Effector EseN Modulates Expression of Host Genes Involved in the Immune Response CD40 TIRAP TLR3 tmp_locus_29 STAC TLR9 CD14 IRF3 IRF7 TRAF6 RAC1 LBP PMC10149954__F2 Receptors that bind to PEDF and their therapeutic roles in retinal diseases MMP7 BMP4 APC GSK3B LRP5 MMP2 LRP6 MMP9 TNF CTNNB1 PMC9060113__F1 Targeting the PI3K/Akt signaling pathway in pancreatic B‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes BAD PHLPP1 PHLPP2 GSK3B PTEN PMC9652959__F2 Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways SMAD1 APC GSK3B LRP5 SMAD6 SMAD4 LRP6 RHO NLK CTNNB1 PMC11357207__F4 Working model to propose ABC-transporter mediated cholesterol efflux reduces the pro-inflammatory immune response that initially occurs from T ABCG1 TLR4 ABCA1 PMC9652959__F4 Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways BMI1 JUN SUFU RHO TRAF6 FOS PMC6406942__F2 Base Excision Repair (BER) in mitochondria OGG1 PNKP NEIL2 NEIL3 NEIL1 POLG IL1A SMUG1 PMC7432774__F1 Biology of tumor hypoxia ATF4 MTOR XBP1 PMC3025384__F2 JAK/STAT3 signaling pathway transmits information from cytokine/chemical signals outside the cell, through the cell membrane, and into the gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell STAT3 TLR4 NLK MTOR TRAF6 CTNNB1 MYD88 PMC8174842__F5 Dickkopf-1: A Promising Target for Cancer Immunotherapy CKAP4 IL13 DKK1 PMC3025384__F3 Wnt signaling plays central role in embryogenesis and human diseases including cancers BAX JUN BAD TRADD EGFR BCL2 ATF2 TBP TRAF6 TRAF2 CTNNB1 PMC3724399__F1 PI3K/Akt/mTOR pathway RHEB TSC2 TSC1 PTEN EIF4E PMC8508518__F2 Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer SOCS1 SOCS3 SRC PMC8147235__F2 Neuroinflammation in Sepsis: Molecular Pathways of Microglia Activation NLRP3 MTOR IL23R PMC5959746__F3 The biology and therapeutic management of melanoma brain metastases PTEN CCL2 TNF PMC7492550__F1 Identified mechanisms of molecular resistance to anti-TNF therapy in IBD patients OSM CD14 IL7R IL23R PMC8483971__F1 Ethnic Differences in Iron Status BMP6 TFR2 BMP2 HAMP HFE HFE2 PMC7780046__F3 Nuclear factor kappa B (NF‐KB) signaling by N‐myc downstream‐regulated gene 2 (NDRG2)/protein phosphatase 2A (PP2A) complex CD40 NDRG2 LTBR RELA RELB PTEN PMC7780046__F5 Enhancement of epithelial‐to‐mesenchymal transition (EMT) via the loss of N‐myc downstream‐regulated gene 2 (NDRG2) activity CDH2 NDRG2 SMAD2 SMAD4 PMC10780299__F4 Activation of the NFKB/MAPK signaling pathway by saponins regulates the expression of a series of immune-related cytokines, NO, surface-stimulating factors, and mRNAs and/or proteins of the cell cycle CSA2 IL2 ATF2 MYD88 PMC10780299__F3 Saponins activate the TLRs signaling pathway through TLRs, upregulate class I and II MHC molecules in APCs, and promote antigen capture, processing, and presentation CD80 APC PMC8414384__F2 Hypoxia in inhibiting dendritic cells by VEGF signaling in tumor microenvironments: mechanism and application VEGFB VEGFC NRP1 ARHA VEGFA MYD88 PMC6433121__F4 Proteins that Are Rhythmic in the Pentose-Phosphate Pathway Peak in Anti-phase to Those in Glycolysis ENO3 HEL-S-49 FBP1 EMP3 GPD1 PMC7936245__F4 Possible proximal tubule epithelial cell signals in glomerulonephritis and renal cell carcinoma STAT3 CYP27B1 CYP24A1 NLRP3 SPDL1 EPO PTH CCL2 SIRT1 FGF23 PMC5594548__F7 RNAi amplification, spreading and transcriptional gene silencing pathways ZFP1 SMG6 SMG5 PMC6812026__F2 Important metabolism-related cellular signaling cascades where FKBP51 was shown to play a decisive role (see main text for further details) CORT UCP1 IRS1 PMC11657595__F2 Mechanisms of GDF15 expression, maturation and secretion ATF3 KEAP1 GDF15 ATF4 PMC7344784__F5 Activation of ATM signaling predicted by IPA-based pathway analysis ATR H2AX CDK2 ATM ATF2 MDM2 MDC1 PMC8072021__F3 Cellular Prion Protein—ROCK Connection: Contribution to Neuronal Homeostasis and Neurodegenerative Diseases ELL APP ARHA PMC8883485__F2 FoxO transcription factors regulate mitochondrial biogenesis CYB5R3 TFAM HMOX1 FXN PDK4 NRF1 UROD SIRT1 PMC5743386__F9 Proposed model shows that MTH-3 induces G2/M phase arrest, autophagy and apoptotic cell death (death receptor/mitochondrial pathways and ER stress) in human breast adenocarcinoma MDA-MB-231 cells CDC2 MT3 ATG12 CCNB1 ATG5 FADD PMC9465411__F5 Recent advances on development of p21-activated kinase 4 inhibitors as anti-tumor agents PAK4 VCAM1 CTNNB1 PMC5787447__F5 Current research on head and neck cancer-associated long noncoding RNAs FZD5 EZH2 PTEN VEGFA CTNNB1 PMC5787447__F3 Current research on head and neck cancer-associated long noncoding RNAs BMI1 TSHR CDKN1A IQGAP1 EZH2 CTNNB1 PMC5787447__F2 Current research on head and neck cancer-associated long noncoding RNAs CDK6 EZH2 PTEN CDK4 PMC7854724__F6 TGFB signalling acts as a molecular brake of myoblast fusion TGFBR2 SMAD2 SMAD4 TGFBR1 PMC9305853__F4 Global analysis of differential gene expression within the porcine conceptus transcriptome as it transitions through spherical, ovoid, and tubular morphologies during the initiation of elongation PLN IFNG FGF7 CXCL12 TGFB1 IGF1 IGF1R FGF10 IL1B FGFR2 PMC5372786__F1 Pathway for synthesis of ceramide, sphingomyelin, and sphingosine-1 phosphate S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 PMC6025071__F1 IDH pathway and targets in acute leukemia BAX BCL2 HEL-S-26 PMC6537282__F1 New biologics and small molecules in inflammatory bowel disease: an update AK3 EPO TPO PMC5381705__F4 Target genes of Tongcheng/Landrace specific DEmiRNAs' KEGG pathways enrichment analysis (a) Landrace specific DEmiRNAs target genes enriched in cell cycle pathway DBF4 CASP9 BAD FAS TRADD PCNA SMC3 MYT1 NGF RAD21 CDK7 CASP3 CDK2 CASP10 CDK4 FADD PMC8267408__F1 Chemistry-Assisted Proteomic Profiling of O-GlcNAcylation OGA OGT PGM3 NAGK GALK2 PMC7438479__F8 Pathway that Tisp40 regulates Ischemia-reperfusion induced pyroptosis in kidney GSDMD NLRP3 IL1B PMC10779351__F5 Illustration of Ferroptosis in Pancreatic Beta Cells and Its Relation to NADPH TF GLS GPX4 TNF HEL-S-64p PMC10779351__F4 Illustration of Insulin Signaling and Resistance Pathways MTOR TRAF2 IRS1 PMC10779351__F3 NADPH in Insulin Secretion from Pancreatic Beta-Cells SENP1 MNT PMC7247689__F2 Mitochondrial homeostasis is based on the balanced interplay between biogenesis and mitophagy TFAM PINK1 MTOR NRF1 PMC10779351__F2 NADPH Production Pathways in Cells MTHFD2 ME3 MTHFD1 HEL-S-162eP MNT ME1 HEL-S-26 PMC9035791__F1 Th17 Pathway in Vascular Inflammation: Culprit or Consort? IFNG IL17RC RORC IL18 FOXP3 TNF PMC4066870__F4 Smoke mediates EGFR/Src-dependent and independent cell migration LIMK1 EGFR SRC PMC9130572__F2 Pyroptosis: Role and Mechanisms in Cardiovascular Disease HMGB1 GSDMD NLRP3 PMC8059808__F2 Boolean module is a dynamic module including Snf1, PKA, and TOR pathway as well as crosstalk between them SELL DAP KIN PMC4959097__F1 Cholesterol biosynthetic pathway IDI2 HMGCR PMVK MVD IDI1 MVK PMC9035791__F4 Th17 Pathway in Vascular Inflammation: Culprit or Consort? RORC IL18 FOXP3 PMC5045062__F2 Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism ACLY TG PGAM1 HEL60 ACO2 HEL-S-133P PHGDH GYS1 HK2 HEL-S-87p HEL-S-26 PMC7780046__F1 N‐myc downstream‐regulated gene 2 (NDRG2) is a key regulator of cellular stress responses NDRG2 PTEN PMC6627250__F1 Neoplastic transformation of melanocyte STAT3 CDKN2A FBXW7 MME SPARC BRAF NRAS POLI TERT PTEN NOTO PMC7845582__F2 Vaccine Therapies for Cancer: Then and Now CD40 TAP1 TAP2 PMC7677583__F1 JAK inhibition and immune regulation by the JAK pathway PRLR EPOR JAK3 IL21R IL7R JAK1 GHR IL23R TYK2 PMC3964483__F1 Outside the Box Signaling: Secreted Factors Modulate GnRH Receptor-Mediated Gonadotropin Regulation TF JUN SF1 EGR1 CGA LHB GNRHR SRC FOS FSHB PMC11944057__F2 Crosstalk between the PI3K/AKT/mTOR pathway and the MAPK pathway PTEN MTOR IRS1 PMC4216797__F3 Mechanism and Role of AMPK activation RHEB TSC2 TSC1 CAMKK2 ULK1 FOXO3A PMC10981134__F1 Main alterations in TCR signaling pathway and accessory molecules associated with autoimmunity/immunodeficiency CD80 STAT5B LAT ITK GRB2 FOXP3 LCK PMC9500666__F8 Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells BAX BCL2 ATF4 PMC4528105__F1 A Protein in the Hippo Signaling Pathway Serves as a Point of Cross-talk to the mTOR Signaling Pathway♦ LATS1 LATS2 RICTOR AMOTL2 MTOR PMC8040477__F4 Epidermal growth factor receptor (EGFR) signaling pathway and potential mechanism of resistance to cetuximab and panitumumab EGF HBEGF HGF TGFA EPHA2 AXL EGFR MMP9 MTOR PMC8949405__F2 MicroRNA-mRNA Regulatory Network Mediates Activation of mTOR and VEGF Signaling in African American Prostate Cancer CDC42 CASP9 BAD PXN MAPKAPK2 PPP3CA SRC KRAS MAPK3 PMC8949405__F1 MicroRNA-mRNA Regulatory Network Mediates Activation of mTOR and VEGF Signaling in African American Prostate Cancer RPS6 PIK3CA EIF4B STK11 DDIT4 BRAF IGFBP2 HIF1A MTOR IRS1 EIF4E STRADA RHEB TSC2 RICTOR PRKCE PMC5362437__F5 Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3Beta-involved Wnt/Beta-catenin pathway SOX2 GSK3B LEF1 CTNNB1 PMC8652015__F4 Molecular mechanism of chronic stress affecting the occurrence and development of breast cancer and potential drug therapy EGR1 NTSR1 IGF1R PMC6606008__F4 Hippo Pathway for tumor suppression LATS1 LATS2 VGLL4 PMC6606008__F3 Wnt signaling pathway with and without ligand binding and APC mutations APC PMC6606008__F2 Process of Hedgehog pathway begins on binding of specific ligands such as exo-secretion ligand Shh bind to the trans-membrane receptor PATCHED1 (PTCH1) it initiates the HH-GLI pathway ARRB2 SUFU PTCH1 GSK3B SMO PMC4283829__F9 Key role of transient receptor potential melastatin-2 channels in amyloid-Beta-induced neurovascular dysfunction TRPM2 PARG CD36 PMC8237272__F6 LGR5 enhances the osteoblastic differentiation of MC3T3-E1 cells through the Wnt/Beta-catenin pathway APC RUNX2 GPR49 CTNNB1 PMC3417440__F1 Cell death regulation: Signalling pathways and potential sites for pharmacological intervention STAT3 BAX BAD FAS TRADD INA MTOR RHO TNF CTNNB1 BCL2 SRC APAF1 TRAF2 CCND1 CDK4 FADD PMC10095594__F1 Canonical Wnt signaling pathway BCL9 APC LRP5 LRP6 CTNNB1 PMC3889573__F2 Ras, cAMP/PKA, and MSIL signaling pathways in C CDC42 NRG1 MSI1 MSL1 GPR4 RAC1 PMC3889573__F1 HOG signaling pathway in C ATF1 GPD1 AQP1 PMC3889573__F3 Ca2+/calcineurin, Rim101, and Pkc1/Mpk1 MAPK signaling pathways in C SP1 HEL-S-11 PMC11530815__F3 Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment BAX FADD PMC11530815__F2 Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment BAD GRB2 MTOR PMC8601278__F3 Bioinformatics analyses of the pathogenesis and new biomarkers of chronic obstructive pulmonary disease CD3D ZAP70 PIGP LY9 NDRG2 KLRB1 NUP88 CYCS FLT3LG CD5 CD7 CD22 MYC PEX26 GTF2F1 FBXL12 CCR7 ITK PINX1 TBP CD6 THOC7 ARHH RPS23 RPS4X CD8B1 BPI ORM1 RIOK1 P2RY8 IL7R LDHB TAF9 SNRPN SATB1 LTB RNF157 MLLT3 RUVBL1 KLRG1 BCL2 GPX7 TCF20 SLC25A37 FXN LAT PLEKHB1 TIMM44 ATP10A RORA MPO GPR18 PIGY CYFIP2 ATL1 PLD4 IL27RA CD48 KLHL32 MRPL1 RPP38 TIMM9 CNOT10 BIN1 KLRK1 GMDS DPH5 RPS27A DEFA4 COPS8 CD40LG GATA3 CD96 HPR UBASH3A HP CD3G TOMM20 LEF1 LCK PMC10535809__F2 Host and HBV Interactions and Their Potential Impact on Clinical Outcomes FAS SET PMC7176436__F1 De novo and salvage pathways of purine synthesis in eukaryotic cells APRT GMPR ADSL PMC8233740__F1 Using Diatom and Apicomplexan Models to Study the Heme Pathway of Chromera velia CPOX COCH FECH UROD UROS PMC2745384__F6 RCAN1 mediated regulation of cell proliferation and apoptosis: Schematic shows that GC-dependent GR activation and subsequent MAP kinase-dependent phosphorylation enables GR binding to GRE sequences on target genes GC RCAN1 RCAN3 PMC8000936__F4 DDX11-mediated regulation of EZH2-p21 and PI3K/AKT/mTOR signaling pathways in HCC cells DDX11 EZH2 MTOR PMC3921546__F1 Representation of epidermal growth factor receptor pathway in response to therapy with anti-epidermal growth factor receptor inhibitors in wild-type and mutant patients EGFR BRAF PTEN MTOR KRAS PMC8289577__F1 Hair Cell Protection from Ototoxic Drugs BAX PMC5599913__F1 The SMC1 participating in DNA damage repair signaling pathway RAD18 RAD50 MRE11A BRCA1 ATM MDC1 PMC8876688__F1 Potential of Nrf2 Activation as a Therapeutic Target in Systemic Lupus Erythematosus ACLY MTHFD2 TXN GCLM GCLC FASN ATG2B SRXN1 HEL-S-30 ATG5 IL1B PMC12220111__F1 Modular engineering design for the compartmentalized synthesis of taxifolin in the peroxisomes of S FAT1 PPY CIT PMC2593565__F3 Epithelial barrier function by lactobacilli LTA EGFR MYD88 PMC3442422__F1 The Sre1 regulatory pathway UBR1 OFD1 ERG PMC7037748__F2 Regulation of the Wnt/Beta-catenin signaling pathway when it is inactive (OFF) and when it is active (ON) SOST RNF43 APCDD1 DKK1 LRP5 ZNRF3 LRP6 GPR49 CTNNB1 PMC8131840__F2 Complexity of the Tumor Microenvironment and Its Role in Acute Lymphoblastic Leukemia: Implications for Therapies STAT3 STAT1 JAK3 JAK1 PMC7037748__F1 Wnt/Beta-catenin signaling pathway, which is inactive in the absence of Wnt ligands (OFF) and active upon binding of Wnt ligands (ON) BCL9 APC GSKIP LRP5 LRP6 CTNNB1 PMC6448643__F1 Illustration showing the activation of a T lymphocyte (via a three‐signal pathway) by an antigen‐presenting cell CD40 JAK3 MTOR PMC6700246__F1 Sphingolipid metabolic pathway CERS3 CERS5 CERS1 tmp_locus_29 CERS2 HEL-S-5 PC CERS6 PMC3542528__F4 Protein network analysis of hits reveals multiple connections between signaling molecules and Golgi proteins FLT3 CSNK1G2 GAP43 CCK NRBP2 NEK11 NEK2 KIF20A PTPRF FGFR2 MAP3K2 TEC SRPK2 GCK AXL MARK4 EPHA1 CXCL10 TSSK2 ERBB3 OSBP TBCA FBP2 DGKD AURKB NPR2 PRKX GABARAPL2 GOLGB1 PPP2CA DUSP2 TGFBR1 RIPK2 PRKCE NRBP1 COPB2 SRPK1 DGKZ CAV2 LCP2 PTPRU CDKL2 AK7 BMX GBP1 VRK3 RPS6KB1 STX7 SNAP25 NLK GJA1 PMC9053805__F5 In silico identification of novel biomarkers for key players in transition from normal colon tissue to adenomatous polyps STAT3 MS4A1 CD69 CD14 PTPRC HLA-DPA1 IL10RA TNF KRAS HLA-DQB1 SET SLAMF7 CSF2RB CD37 GPNMB PMC9053805__F4 In silico identification of novel biomarkers for key players in transition from normal colon tissue to adenomatous polyps VIP STAT3 CXCL12 CITED2 PTN CD27 F13A1 GREM2 TNF KRAS SET SST GPR18 CCL19 SLIT2 IGF1 SCG2 NDN TNFRSF17 MSX1 FHL1 BMP5 PMC4576153__F1 Negative regulators take action at almost all steps of TLR signaling MAL IRF3 IRAK2 IRF7 TRAF3 TRAF6 CYLD IRAK4 FADD MYD88 PMC3542528__F5 Various subnetworks of signaling molecules that regulate Golgi structure PIK3CA RAF1 MAPRE1 PPP3R1 ASAP1 EVI1 STK4 PTEN MAP4K2 DUSP2 TGFBR1 FGFR2 CLINT1 CLASP1 ASAP2 MYO1C ROCK1 DGKZ HEL-S-15 PIP5K1A DUSP8 TAOK2 LIMK2 MYO6 COPA KIF1A OSBP PAK1 GORASP1 PDGFRA CASP3 NLK TRAF2 PMC8905735__F9 Ameliorating role of microRNA-378 carried by umbilical cord mesenchymal stem cells-released extracellular vesicles in mesangial proliferative glomerulonephritis SMAD2 TGFBR1 PMC4597147__F4 Regulated protein networks in GM-BMMs versus M-BMMs NR2C2 ZAP70 STAT3 AEBP1 KEAP1 CD22 HIF1A MYC DOK1 BIRC5 FBXW7 FYN MAPK8IP1 NQO1 IDI1 GHR LPL NOS2 USO1 APOE DLG4 SREBF2 TNF TFAM PITPNC1 RPIA PLCB2 ENO1 ITSN1 NR1H2 CD36 PCNA AACS NCOA6 RHO RBBP7 HEL-S-128m TOP2A ANXA4 RRM1 FASN CD19 RAC1 CBL NR2A1 FABP5 PFKP STX7 ATP6V0D2 FOXA2 NLK LYN IFNB1 CSN2 EHD1 POLD3 MS4A1 RFC1 SLC2A4 GPX4 VAMP4 DOCK2 PYGL RBBP4 CD74 FDPS ZFP36 LDHB GSTM5 PRIM1 FOS HMGCS1 GM2A ELMO1 FOXO1 CSK Nbla10317 MVD IL8RB GRB2 CDC42 CYP2A13 LAT PML CTNNB1 CIDEA ATM ATF4 HBB MED13 UBC NR1H3 PAG1 PTPN11 CXCL2 SLC7A2 ELAVL1 NFE2L2 HEL-S-102 LPIN1 CIDEC PMC7081333__F8 Piscidin-1 anticancer signaling pathway FIS1 OPA1 MFN1 MFN2 PMC6260860__F3 Different gene expression profiles in metabolic pathways of E HEL107 RPE ATR HEL-S-162eP PTS PC CS PMC4819695__F1 MYC: regulator of post‐transcriptional mechanisms MAX POLL SF3B1 FBL POLI BUD31 MYC NCL PMC7250912__F1 Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways BRAF KRAS PMC7038207__F2 Connexin hemichannels in mechanotransduction of osteocytes SOST RHO CTNNB1 PMC3828201__F1 ERK and PI3K signaling networks are shown, with illustrations of feedback loops and cross talk FOXO3A IRS1 EIF4E PMC8652015__F2 Molecular mechanism of chronic stress affecting the occurrence and development of breast cancer and potential drug therapy TH STAT3 USP28 COX2 HEL-S-133P PRL CCR2 ADRB2 PTEN MTOR MYC CCL2 PMC4816099__F2 Controlling a variety of extracellular and intracellular processes via the phospholipid code TRADD ARHA PMC1866250__F7 Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance TG DGAT1 PMC7892797__F1 All detected PLA2/COX pathway genes and regulatory factors and alterations in their transcription levels between patients with schizophrenia and healthy controls HCAR2 PTGDR PTGER2 COX1 PTGIS PTGER1 FACL4 PTGER4 PTGDR2 PTGIR CREB1 PMC6390002__F2 Comparative analysis of genes in regeneration-related signaling pathways of regenerative animals STAT3 SMAD2 LIF APC GSK3B DUSP9 SOX2 NODAL FGF2 CTNNB1 LATS1 TCF3 LATS2 BMP4 TBX3 SMO GRB2 PMC6032276__F6 Differential regulation of skin barrier proteins by Rhodiola crenulata root extract AHR FLG CYP1A1 IVL OVOL1 PMC4665079__F6 Autophagic signaling pathway LAMP2 ATG10 ATG3 ATG12 ULK1 SNAP29 BCL2 STX17 ATG5 VAMP8 PMC4132373__F1 A healthy neuromuscular junction (NMJ) is a tripartite synapse composed of a motor neuron (MN) terminal synapsing onto a muscle fiber CD44 SEMA3A NRP1 APP EPHA4 PMC4665079__F4 Death receptor signaling pathway FAS TRADD TNF TRAF2 FADD PMC9488186__F1 Promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis RHEB TSC2 SGK1 ULK1 DEPTOR PMC9274113__F2 Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases MOK ASL CLC PMC4665079__F2 Mitochondrial apoptotic pathway HTRA2 APAF1 PMC6829479__F1 Effect of pharmacological and transcriptional inhibition of lysine-specific demethylase 1 (LSD1) on induction of the cell cycle and DNA damage response (DDR) pathway in microvascular endothelial cells (HMEC-1) ATRIP CCNE1 PCNA PMC8278111__F1 Complex role of Wnt ligands in type 2 diabetes mellitus and related complications CDC42 APC GSK3B LRP5 LRP6 RYK ARHA CTNNB1 BCL9 COX2 NLK SRC CCND1 PMC9169354__F2 Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer LATS1 FRMD6 AMOT AREG MYC ID1 PMC9169354__F1 Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer LATS1 LATS2 NF2 VGLL4 PMC8151045__F1 PD-1 and LAG-3 Checkpoint Blockade: Potential Avenues for Therapy in B-Cell Lymphoma CD80 PMC1929113__F6 Upregulation of cyclins and CDKs in melanoma cells ATR CD2 SMAD4 CDK2 ATM SKP2 PMC3179938__F3 Top IPA generated network CD40 LILRA2 SOCS4 KLRB1 IRGM PIBF1 ALOX15 ADFP ALOX12 PMC6444272__F2 Herb-compound-target-signaling pathway network of BSJPD TH BAX PTEN VEGFA PMC5959770__F2 Perspectives on Glycosylation and its Congenital Disorders DOLK DDOST COA7 GANAB PMC8437140__F2 H19 in liver injury and fibrosis EPCAM PTBP1 BCL2 CCL2 PMC6873994__F4 Predicted potential targets to combine with MAPK/ERK inhibition, using graph analytics POR MLST8 POLR2G LAT PRC1 PPP2R1A RHO TUBB PMC8437140__F1 The bile acid/FXR pathway by lncRNAs APOC2 TG CYP8B1 CYP7A1 PMC7691682__F8 Some transcripts encoding enzymes involved in the glycosylphosphatidylinositol (GPI)-anchor protein biosynthetic pathway are down-regulated in the CF specific medium (CFSM) culture condition (G condition) PIGC GPAA1 PIGF PIGH DPM2 PIGW PIGL PIGK PIGM PISD PGAP1 PMC8196898__F5 Circulating PTGS2, JAG1, GUCY2C and PGF mRNA in Peripheral Blood and Serum as Potential Biomarkers for Patients with Metastatic Colon Cancer IRF6 COMP MAML1 COX2 DLL4 STH BCL2 MMP9 NOTCH1 PMC6993871__F6 Simplified schematic of the cholesterol biosynthesis pathway and MARCH6 targets HMGCR EBP DHCR24 DHCR7 PMC8014339__F7 F528 treatment ameliorated smoke-induced inflammation and emphysema through NFKB signaling pathway MMP2 IL6 MMP9 PMC10816189__F5 Cell cycle metabolic pathway, with Zhuansihao serving as the control and 071113 as the experimental group STAG2 CDC20 PCNA CDC6 STAG1 ORC6 SMAD2 SMC3 APC CD7 CD14 SMAD4 ORC3 SKP2 ORC2 CDK7 CDC45 CDK2 MDM2 PMC10816189__F6 Plant hormone signal transduction pathway, with Zhuansihao serving as the control and 071113 as the experimental group BIN2 EBF2 COIL PMC5850959__F6 Transcriptomic data shows immunometabolic effects of vitamin D FH ACO2 IDH3B CS SDHD SDHA SDHB SUCLG1 OGDH SUCLG2 DLD MDH2 SDHC PMC3350847__F2 Canonical Wnt pathway APC GSK3B CTNNB1 PMC5563989__F2 The apoptosis regulatory network under ER stress ATF4 EIF2A PMC11586091__F1 JAK/STAT3 signaling pathway regulated by circRNAs STAT3 NLK CCL2 PMC6398012__F6 Proposed mechanism by which type 2 diabetes (T2DM) and aerobic exercise can affect the brain and lead to alterations of hippocampal glucose metabolism with subsequent effects on synaptic plasticity-associated proteins NLRP3 IL16 MTOR SIRT1 PMC6027299__F2 Global view and function analysis of the ceRNA network in GC PCNA CXCL1 CLSPN CHTF18 TYMS SKP2 KIF23 TFRC HJURP RIPK2 CENPK ATP13A3 TTK SMC2 CENPU TOP2A MTHFD2 NUP107 OPA1 CENPN DTL RRM2 ARHGAP11A LRP6 PROSER1 RBL1 PRKDC TONSL PMC11586091__F3 Function of exosomal circRNAs in tumorigenesis TMED10 E2F2 RSF1 MTA2 ANXA2 PFKFB2 KDR PDK2 MTOR BPTF ARHGAP24 PMC4968756__F7 Model for p53-mediated resolution of replication barriers RAD18 MRE11A HLTF POLI ZRANB3 PMC6492315__F4 Schematic overview for the roles of miR-24, miR-23a and miR-145 in TGFB signaling in AKI TGFBR2 CASP8 SP1 FOXO3A SMAD2 CASP3 PLG SMAD4 APAF1 TGFBR1 PMC8315560__F1 Cancer stem cells, epithelial-mesenchymal transition, ATP and their roles in drug resistance in cancer CTNNB1 GPT PMC8181757__F6 CHOP Regulates Endoplasmic Reticulum Stress-Mediated Hepatoxicity Induced by Monocrotaline ATF4 EIF2A INS PMC3328674__F1 Exercise-stimulated glucose uptake in skeletal muscle PPARG NDUFB6 MTOR NRF1 RAC1 PMC3098671__F2 Endoplasmic-Reticulum Calcium Depletion and Disease CHP1 ATF4 EIF2A XBP1 PMC5545609__F1 Normal endothelial cell metabolismA schematic of the principal pathways in healthy EC metabolism and the rate-limiting enzymes, carriers, and transporters (shown in blue) HEL107 FAS GLS F2 FABP4 PMC8085551__F6 Transcriptomic and Metabolomic Profiling Reveals the Protective Effect of Acanthopanax senticosus (Rupr. & Maxim.) Harms Combined With Gastrodia elata Blume on Cerebral Ischemia-Reperfusion Injury HPD ASAH2 MTAP TK1 NME6 PAH DEGS2 PMC4654537__F6 Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule PALM HEL-S-302 CLPP NR1C2 CHRNB1 SCAI FCHO1 CMBL PMC5545609__F4 Diabetic endothelial cell metabolismIn diabetic ECs, hyperglycemia increases production of ROS through a variety of intracellular sources, including NADPH oxidase, xanthine oxidase, uncoupled eNOS, and impaired pentose phosphate pathway (PPP) F2 HEL-S-162eP F3 PARP1 PMC5005329__F1 Current view on T cell NNCS in regulation of immune function ZAP70 ORAI1 STIM1 APC ChAT PMC5053480__F5 Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation POSTN SERPINC1 PVALB COMP COL1A1 MYL1 COL12A1 PMC8268101__F2 Molecular Characteristics of RAGE and Advances in Small-Molecule Inhibitors CDC42 STAT3 RAC1 PMC5053480__F4 Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation APRT RBM8 CALU CETN3 COMP MTAP SFRS3 HEL-S-78p TBCA POSTN PVALB COL1A1 MYL1 ZRANB2 NME2 CRABP1 COL12A1 MDH2 MB NAA38 TRA2B PMC6787681__F4 AT-rich interactive domain 1A (ARID1A) chromatin remodeling abnormalities in ovarian clear cell carcinoma (OCCC) ARID1A CDKN1A EZH2 MTOR MYC PMC9144171__F3 Endocardial Regulation of Cardiac Development TBX2 BMP10 HEY2 TBX20 ERBB4 VEGFA HAND2 VCAN POSTN NRG1 NPPA MSX1 BMP2 ERBB2 HAS2 TBX3 TWIST1 NOTCH1 MSX2 PMC6192708__F2 Biomedical Informatics on the Cloud: A Treasure Hunt for Advancing Cardiovascular Medicine SFTPA1 IGF1 IGFBP4 APP PMC8517477__F2 STING Signaling and Sterile Inflammation HMGB1 CGAS CXCL10 PMC8517477__F1 STING Signaling and Sterile Inflammation TBK1 CGAS IRF3 PMC8393318__F8A Gastroprotection against Rat Ulcers by Nephthea Sterol Derivative TSC2 BAD RPS6KB2 CHUK PTEN MTOR CREB1 PMC10522995__F1 CREB-Regulated Transcriptional Coactivator 2 Proteome Landscape is Modulated by SREBF1 CRTC2 PMC10376827__F1 Dissecting the Protective Effect of CD8+ T Cells in Response to SARS-CoV-2 mRNA Vaccination and the Potential Link with Lymph Node CD8+ T Cells IFNG FAS APC TNF PMC7283386__F2 Signaling pathways in wear debris-activated osteoblasts BAX BCL2 CTNNB1 PMC7855700__F1 Main IDO1 and ARG1-mediated pathways that regulate autoimmunity, cytotoxicity, and neuroprotection IDO1 AHR ARG1 SRC PMC4905428__F1 Regulation of Smad4 by the FGF/MAPK and Wnt signaling pathways EGF SMAD2 APC SMAD4 PMC10935121__F8 DEG pathways involved in the sesquiterpene synthesis pathway IPP MVD MVK PMC8071330__F3 Ovarian cancer stem cell (OCSC)-associated signaling pathways STAT3 PTCH1 LRP5 LRP6 SMO PTEN NOTCH3 CTNNB1 PMC6896163__F2 FOXO1 regulates activation and function of dendritic cells RICTOR FOXO1 TLR4 CCR7 MTOR PMC4237178__F4 Canonical and non-canonical Wnt pathways exert opposite effects on the formation of the vertebrate NMJ MUSK DVL1 LRP4 RHO CTNNB1 PMC11781520__F1 MiR-29s in the signalling of innate immunity SOCS1 CD80 STAT2 IRF9 TLR5 IL6 TNF CCL2 MYD88 STAT1 COX2 NOD2 TLR8 TLR7 JAK1 TYK2 PMC6382076__F1 Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells TBK1 TGFBI TRADD TANK IFIT3 MAPKAPK3 IFIT2 IRAK1 SMAD4 IRAK2 TRAF3 MYC CCL2 TRAF6 IRAK4 TRIP6 MYD88 TGFBR2 STAT1 HLA-G TLR4 IFITM3 NOD2 OASL MX2 GBP2 CSF2 IFITM2 STAT2 IRF9 MAL FABP4 IRF3 MMP9 IRF8 TNF ATF3 MT2A IFNAR2 RELA IFNAR1 JAK1 TYK2 HLA-A FADD PMC8583789__F7 RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair SHLD1 BARD1 MRE11A BRCA1 RIF1 ASTE1 SHLD2 PMC2945950__F5 Moral graph Dm obtained from BCR pathway SYK CD81 CD72 RASGRP3 GSK3B CD22 BLNK CD19 BTK BCL10 PLCG2 LYN GRB2 PMC4275311__F3 Cellular and metabolic functions for autophagy in cancer cells KEAP1 MTOR TRAF6 PMC10750294__F8 MANF Promotes Unexplained Recurrent Miscarriages by Interacting with NPM1 and Downregulating Trophoblast Cell Migration and Invasion PCNA NPM1 MMP2 MMP9 PMC2945950__F6 Triangulated graph Dt obtained from BCR pathway SYK CD81 CD72 RASGRP3 GSK3B CD22 BLNK CD19 BTK BCL10 PLCG2 LYN GRB2 PMC4275311__F1 Cellular and metabolic functions for autophagy in cancer cells ULK1 BRAF ATF4 EIF2A MYC ATG5 PMC2945950__F1 BCR signaling pathway SYK BOLL BTK BCL10 BCR CD22 BLNK CD19 LYN GRB2 DAO PMC8092109__F9 Cinnamaldehyde inhibits the growth of Phytophthora capsici through disturbing metabolic homoeostasis IVD CAD MCC PMC2945950__F2 ERBB signaling pathway EGF JUN BTC MTOR SHE NRG4 PMC8525858__F7 Small-molecule Akt-activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2 KEAP1 NQO1 TLR5 PMC6468910__F3 ER stress and chemo-resistance: Role of protein kinase R-like endoplasmic reticulum kinase (PERK) BAX KEAP1 HIF1A ATF4 EIF2A PMC9033823__F6 Oncogenic circuit involving FUS-DDIT3, the IGF-IR/PI3K/AKT pathway, and the Hippo/YAP1 axis in MLS LATS1 IGF2 YAP1 PMC12164393__F2 ICI myocarditis CXCL11 TH CCL3 ANGPTL2 CCL4 CCL5 CXCL10 PMC6481335__F4 Heatmap and expression values of probe sets related to irinotecan metabolism in both liver and tumor UGT1A1 ABCC1 CES2 CES1 CES3 APC ABCG2 ABCC2 PMC5713423__F1 Schematic representation of Cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon genes(STING) signaling mediated T cell priming in tumor microenvironment CD80 CGAS PMC3060045__F2 ErbB receptor signaling and regulation EGF TGFA ERBB4 EGFR WWOX ERBB2 GRB2 SHE SRC PMC9561988__F1 Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer ATR RAD51 BRCA2 WEE1 CDK2 ATM MDM2 SSB PARP1 CDK4 PMC3437743__F1 Glutathione and modulation of cell apoptosis BAX TRADD TRAF2 FADD PMC6798812__F11 Cell Therapeutic Strategies for Spinal Cord Injury CNTF NGF GDNF C2 BDNF RET PMC6651805__F6 Schematic diagram summarizes the mechanism whereby CCN3 promotes Runx2 and osterix expression in osteoblasts CCN3 RUNX2 PMC9353920__F6 Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study MMP14 LAT INA LIF APC IL21R SOCS3 TRAF3 IRF4 TNF DAO RORA GATA3 EDN1 AHR TRAF1 FOXP3 IL23R TRAF2 CASP10 FADD PMC9692260__F3 Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical VCAM1 TNF PMC4581604__F9 Diagram summarizing the Rheb-mTOR signaling pathway and findings presented in this study RHEB GSK3B IRS1 PMC9692260__F1 Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical BAX NLRP3 VCAM1 APAF1 PMC2846691__F1 Pathways initiated by ACSL, FATP, and ACSBG isoforms LPA PC PMC12084380__F5 Therapeutic strategies targeting immunosenescence TREM2 FASN ATM TNF PMC12084380__F4 Distinct phenotypic and functional alterations in immune system in aged individuals with sepsis compared with young patients STAT3 TREM2 IKZF1 NLRP3 TLR4 MFN2 CXCL1 KLF5 FY PMC12095308__F4 Antiviral type I interferon (IFN) response pathway and known evasion mechanisms of orthohantaviruses TBK1 MAVS STAT2 IRF9 TLR9 IRF3 IRF7 TRAF3 TRAF6 STAT1 TRIM25 TLR3 IFNAR2 TLR4 IFNAR1 TLR8 TLR7 TYK2 PMC3111376__F9 Overrepresented miRNA regulatory pathways in PKD PMC9163834__F7 MicroRNA Expression in Circulating Leukocytes and Bioinformatic Analysis of Patients With Moyamoya Disease NR1C1 SOST INVS APC NOTUM CER1 RYK PMC6469018__F3 Signaling pathway of different DCs receptors (CLRs) SYK BCL10 CARD9 PMC12084380__F3 Prematurely aged immune cells during sepsis contribute to immunosuppressive state CD80 CD27 MREG IL33 CXCR4 PMC12084380__F2 Sepsis induces aberrant aging of immune cells which further exacerbates excessive inflammation CRP CD40 BRD4 CD80 HEL-S-90n TLR4 CASP3 CD14 ATM SERPINB2 CD163 CXCR4 PMC3943605__F4 GENETICS AND EPIGENETICS OF ADRENOCORTICAL TUMORS APC LRP5 LRP6 PMC11964413__F7 Proposed mechanism suggests that ABCG8 upregulation in RT-R-MDA-MB-231 cells mediates cholesterol efflux, leading to increased cancer cell progression through the LRP6/Wnt/Beta-catenin signaling pathway in RT-R-MDA-MB-231 cells ABCG8 FASN LRP6 PLK1 CTNNB1 PMC9524158__F1 New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival USP14 BAX MYC PMC6474664__F3 Identification of unique pathways after treatment with SC-3–141 CENPF LSM12 TAF11 CENPP APC PRC1 DIAPH2 HEL-S-66 SLC27A2 PMC9476729__F2 Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NFKB pathway activation TG NR1C1 INS PMC8278622__F1 Setting the pick: Can PI3K inhibitors circumvent CDK 4/6 inhibitor resistance? RHEB RB1 TSC2 CDK6 GSK3B PTEN CCND1 CDK4 PMC6348405__F1 Mitochondria-to-nuclear retrograde signaling pathways in mammals CA4 KEAP1 ATF4 PMC3185527__F3 Illustration of the type I IFN signaling pathway and its inhibition by the henipavirus P, V and W proteins STAT1 STAT2 IFNAR2 IFNAR1 JAK1 TYK2 PMC6348405__F3 ATF4 is activated by the perturbation of mitochondrial function ALDH2 FXN COX10 MFN1 FGF21 MFN2 ATF4 SESN2 PMC6348405__F2 Activation of MRS reconfigures mitochondrial metabolism in yeast CDH2 MKS1 HEL60 PMC6348405__F5 Growth signal activates ATF4 and mitochondrial metabolism TSC2 TSC1 GSK3B ATF4 EIF2A EIF4E PMC6348405__F4 ATF4 regulates the serine synthetic and mitochondrial Folate-mediated 1C metabolism pathway MTHFD2 PHGDH CTH PSAT1 HEL-S-51e PSPH PMC9409897__F5 Enhancing Genome-Scale Model by Integrative Exometabolome and Transcriptome: Unveiling Carbon Assimilation towards Sphingolipid Biosynthetic Capability of Cordyceps militaris C6 TG PMC6348405__F6 Cooperative gene regulation for mitochondrial quality control by Nrf2 and ATF4 MTHFD2 PINK1 PSAT1 ATF4 ASNS TRIB3 HEL-S-51e PMC4267896__F3 Central LepRb expression sites and related neuronal circuits NTS POMC ARC AgRP SCX PMC7936166__F7 Relationship between AMPK signaling pathway and lipid metabolism in laying hen hepatocytes FAS NR1C1 NR2A1 PMC6798326__F9 TSHR mediated signaling induced OF proliferation through Akt signaling and induction of miR-146a and miR-155 TSHR ZNRF3 PTEN PMC9266727__F1 State-of-the-Art Molecular Oncology of Lung Cancer in Taiwan HEL107 GPX2 SLC40A1 GCLC HEL-S-10 TERT FECH PMC1965265__F6 A schematic representation of differential testosterone action on morphoregulatory gene expression in the rat VP and LP lobes NKX3-1 BMP4 SHH BMP7 FGF10 PMC5530849__F4 KEGG pathway of apoptosis.Notes: The red-colored genes are differentially expressed genes enriched in the pathway in the study NGF FAS CAD GNE TRADD HEL-S-11 HRK TRAF2 PMC6721055__F1 SUMO conjugation/deconjugation cycle SUMO1 SUMO3 SUMO2 tmp_locus_29 SUMO4 CS SAE1 PMC9656535__F5 Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight CDH2 CDK2 CCND1 CDK4 PMC4703831__F3 Genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia STAT3 HEL113 CLIC1 MSLN MCL1 HEL-S-269 FHL2 MBTPS1 SUMO1 WT1 EZR SUMO3 TRIM28 MMP2 COL4A1 HSP90AB1 HNRNPL THBS1 TIMP3 EGR1 NTRK2 YBX1 CXCL10 CAPRIN1 ARAF IGF1 ACTN4 HSPA4 ENO1 DDX3X HLA-A PMC6721055__F3 SUMOylation regulates gene expression during Acute Myeloid Leukemia (AML) response to chemo- and differentiation therapies TF DDIT3 SAE1 PMC3604032__F1 PI3K/Akt/mTOR signaling in breast cancer RHEB TSC2 TSC1 GSK3B PTEN IRS1 PMC1885837__F6 Obstructive nephropathy: insights from genetically engineered animals SMAD2 PLG SMAD4 ARHA PMC9289165__F2 Targeting CD47 as a Novel Immunotherapy for Breast Cancer SIRPA CD47 PMC5391045__F2 Heart Failure in Pediatric Patients with Congenital Heart Disease JUP PLN TCAP PKP2 DSG2 ACTN2 NODAL GPC3 KRAS DSC2 HEL114 HRAS NR2F2 tmp_locus_29 MYL2 TTN MAP2K2 LMNA PMC5710859__F1 Molecular insights into desmoid tumors APC GSK3B TCF4 FAP HES1 CTNNB1 PMC9234166__F1 Tandem Mass Tagging Based Identification of Proteome Signatures for Reductive Stress Cardiomyopathy NDUFB8 ETFDH COX7A1 BDH1 HEL-S-133P GPX4 ACADS ACAD10 RTN4IP1 GPX1 COXFA4 SDHA TG PDHA1 CBR4 UQCRB HEL-S-2a NQO1 NDUFS6 FDX1 XDH HSDL2 HEL-S-165mP PMC7241359__F1 Methotrexate has been recognized by the World Health Organization as an ‘essential medication’, principally due to its broad diversity of mechanisms of action TH HMGB1 RFC1 TLR4 DHFR TYMS HEL-S-70p ACE2 PMC3586519__F1 Schematic illustrating the cancer utilization of the metabolic pathways HEL-S-133P PMC11808587__F2 The role of mGlu5 activation in neuropathic pain TRPA1 TRPV1 CXCL10 CCL2 PMC8717973__F4 Conversion of PanAms into CoA antimetabolites PPCS PPCDC PMC4182169__F2 Nutrient-induced cell proliferation in the crypt BMI1 GPR49 CTNNB1 PMC5102139__F8 Pathway map of NOD-like receptor signaling in independent JU-RME NAIP NOD2 FES PMC3935732__F4 Role of ABL Family Kinases in Cancer: from Leukemia to Solid Tumors STAT3 CRKL SRC CXCR4 PMC11201989__F8 Working model for PD-L1 in the regulation of ciliogenesis RAB8A BBS5 IFT20 IFT140 GLI3 PMC2290973__F2 Pathway Studio diagram of common regulators of differentially expressed genes CDC42 NCAM1 SAG tal-1 SOS1 STAT2 F2R PLG EP300 KDR MEF2C PMC1140402__F2 The central carbon metabolism of E OGA MAL CIT PMC7050137__F3 Different epigenetic signaling pathways regulated during TGF-Beta-induced EMT HDAC1 KDM6B EED HMGA2 EZH2 SETDB1 ZEB2 GAS1 JARID2 PMC6164406__F1 Toll-like receptor (TLR) 4 signaling pathway TIRAP TLR4 IRF3 TRAF3 TRAF6 MYD88 PMC7464074__F1 HER2 signaling pathway, mechanism of action of targeted therapies, and resistance mechanisms PTEN IGF1R MTOR PMC3543090__F8 Model showing the effect of miR-182-5p on the DNA repair pathway BRCA1 CDKN1B RAD17 CHEK2 SMARCD3 ATF1 TP53BP1 PMC2855646__F7 Summary of biosynthetic pathway for O-mannosyl glycans on A dystroglycan in mammals POMT2 POMT1 PMC3543090__F4 MicroRNA-182-5p targets a network of genes involved in DNA repair ATR CREB5 TLK2 SKP2 CCNH HDAC3 RB1 BTRC CDK6 CDK7 RAD17 CHEK2 ATM ATF1 CCND1 TOP2A HEL2 CDK4 HUS1 POLL MSH2 TFDP1 POLI TUBG1 RBBP8 TP53BP1 BARD1 RAD1 CDKN1A BRCA1 CDKN1B CHEK1 SMARCD3 SKP1 CDK2 GADD45A CDC25B YWHAZ PMC9244687__F2 Prolactin: The Third Hormone in Breast Cancer PRL SRC PMC8399337__F1 Epithelial to Mesenchymal Transition in Patients with Pancreatic Ductal Adenocarcinoma: State-of-the-Art and Therapeutic Opportunities EGFR SMAD2 GSK3B SMAD4 IL6 IL1B CTNNB1 PMC7812236__F1 Notch signalling pathway MAML1 MYC HES1 PMC7528681__F1 WNT Signaling in Lung Repair and Regeneration CDC42 JUN RNF43 APC LRP5 ZNRF3 LRP6 ARHA NLK RAC1 CTNNB1 PMC7140873__F2 Analysis of different miRNAs families and their target genes implicated in the regulation of flower induction MYB ARF3 ARF4 PMC5040924__F12 Activation of NFKB and STAT signaling pathway IFNG STAT1 CD14 JAK1 IL1B PMC11703395__F5 Advanced whole transcriptome sequencing and artificial intelligence/machine learning (AI/ML) in imiquimod-induced psoriasis-like inflammation of human keratinocytes TAPBP JUN PSMB6 RAF1 PSMB8 GAS HEL-S-269 PTPN1 PTPN11 MTOR IL6 MAP2 PTPN6 FOS IFNG CCKBR BCL2L1 MHC2TA CDKN1A MAP2K1 CISH PMC8484301__F4 Novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway XPA TBK1 CGAS TLR4 MAL TLR9 TLR5 IRF3 MYD88 PMC6831300__F8 Hypothetic model of signaling pathways involved in the differentiation of hiPSC-CM from mesodermal progenitors APC GSK3B CTNNB1 PMC6580993__F9 Simplified signaling pathway: this simplified signaling cartoon encompasses all significant molecular changes detected in this study in spleen, hippocampus, and plasma after PEA treatment (PEA/sal) LPA NR1C1 MAPK11 CRH IL18 GLA NR1C2 BDNF GPR55 SKI IL1B PMC8215363__F2 Reversing Post-Infectious Epigenetic-Mediated Immune Suppression SOCS1 HDAC3 HMGB1 RELB IRF3 SOCS3 CXCL10 TRAF6 TNF SIRT1 IL1B MYD88 PMC7792133__F3 PI3K-AKT-mTOR inhibitors and CDK4/6 inhibitors orchestrate multiple effects on immune cells in the tumor immune microenvironment CDK6 MTOR CDK4 PMC5650615__F1 Simplified scheme of innate immune recognition mediated by PRRs TIRAP MAL AIM2 IRAK1 IRF3 TRAF3 TRAF6 NLRC4 NLRP3 TLR4 NOD2 NOD1 IL1B PMC7557148__F2 Some key events during early embryogenesis in Arabidopsis MAX PIN1 ARF5 PMC8235365__F10 Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction CD80 CD69 TLR4 PMC5076471__F1 Inositol pyrophosphates and their corresponding bisphosphonate analogues IP6K2 IP6K3 PPIP5K1 IP6K1 PMC11821611__F4 Biosynthetic pathway of flavor in fresh C PIG59 OGDH HEL-S-162eP CS PMC5041197__F7 CD95-mediated cell migration occurs through a Bcl-2/BclxL/VDAC1/MCU-driven mitochondrial calcium loading HTRA2 BAX BAD ORAI1 STIM1 EGFR MCU FADD PMC3185727__F1 Illustration of the endogenous RNAi pathway and therapeutic mimics DGCR8 AGO2 DROSHA PMC8571891__F1 Oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer EGFR GRB2 MTOR KRAS PMC2849133__F4 Main targets of RhoA and ROCK, involved in organization of the cytoskeleton GFAP LIMK2 ARHA PMC11132832__F5 Hub target-pathway network (67 nodes and 95 edges) IFNG TH TGFB1 PMC5286800__F4 Summary of DNA damage-induced breast cancer by estrogen and stressors ATM MDM2 PMC4339278__F1 Inflammasome activation and cross-talk between endothelial cells (ECs) and macrophages (MØ) in atherogenesis NLRP3 CD36 LDLR VCAM1 IL1B MYD88 PMC3361414__F5 Schematic representation of the interplay of T7 gp5.5, gp3, E GP6 GP5 SSB PMC8892214__F2 Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review REST GATA1 BCR EPOR EPO MTOR BCL11A NRF1 SIRT1 PMC6994496__F7 Proposed new pathway that operates upstream of the CRL2VHL complex and involves the UBXN7 cofactor protein and its regulation by mitochondrial MUL1 E3 ligase RBX1 MUL1 UBXN7 ELOC VHL PMC4452181__F4 Correction: Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing PAX4 MNX1 MAFA BACE1 TCF2 FOXA3 NEUROG3 PSEN1 INS IAPP PSENEN MME PDX1 NKX2-2 NR2A2 APP GCK HES1 PKLR HHEX NEUROD1 APOE SNCA BACE2 TNF PAX6 NKX6-1 ONECUT1 NR2A1 CASP3 FOXA2 PMC4081668__F2 Nuclear export of hepatitis B virus mRNAs HEL-S-162eP MYD88 PMC11324288__F1 SLC44A2 mediates the VSMC phenotypic switch in aortic aneurysm KLF4 ACTA2 RUNX1 SMAD2 NRP1 DKFZp686P11128 ITGB3 SLC44A2 PMC4490046__F3 Cell Signaling and Transcription Factors Regulating Cell Fate During Formation of the Mouse Blastocyst CDX2 GATA6 GATA3 PMC7582278__F6 Ingenuity Pathway Analysis (IPA) prediction network of miR-342-3p/-5p and cardiovascular disease VEGFC SFTPA1 PI3 IKBKG PMC8198482__F2 Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis HMGCR APOE LDLR ABCA1 PMC2808370__F7 Possible mechanism by which Wnt determines the specificity of signalling pathway WNT3A DKK1 APC LRP6 RHO CTNNB1 PMC11099600__F4 KEGG Pathway Analysis of ultravist-treated mast cells SLC3A2 MAFK GSK3B PTEN FLCN MTOR RHO TNF SKP2 DEPTOR RHEB GRB10 RNF152 PMC6853184__F5 Pathway enrichment analysis of primary human lung cell secretory proteins with decreased abundance in response to PC MMP7 MMP14 ADAMTS4 MMP19 MMP12 PLG ADAMTS5 CTSS MMP9 MMP15 CTSC EMP1 CD44 NID1 ADAMTS6 ADAM15 MMP2 MMP3 ADAM10 ELANE PMC4770149__F1 Developmental pathways are frequently activated in cancer APC SMO RBPJ PMC4821826__F4 BCR signaling pathway is the top-ranked network with increasing association with HuR in response to NS3/4A overexpression CDC42 CD79B SYK CD79A BAD HCLS1 CARD11 PTEN MTOR MEF2C BTK FYN BCR JUN EGR1 BLNK CD19 PTK2B RUNX3 TCF3 RUNX1 FOXO1 APBB1IP CSK ZNF423 LYN GRB2 LCK PMC6683584__F8 The mechanism of Notch1 signaling and CXCL12/CXCR4 axis in GICs self-renewal, invasion and tumor growth CXCL12 MTOR CXCR4 RBPJ NOTCH1 PMC6610018__F5 Association of cGAS-cGAMP-STING signaling with apoptosis BAX TBK1 CGAS IRF3 PMC6610018__F4 Cross talk between the cGAS-cGAMP-STING pathway and autophagy/mitophagy TBK1 CGAS PINK1 ULK1 SQSTM1 OPTN PMC9682817__F4 Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2 SMAD1 C2 SMAD4 PMC9682817__F3 Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2 APC LRP5 LRP6 RAC1 PMC8914548__F11 TFPI2 suppresses the interaction of TGFB2 pathway regulators to promote endothelial–mesenchymal transition in diabetic nephropathy TGFBR2 SMAD2 SMAD4 SMURF2 TGFBR1 PMC9410841__F11 Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice NLRP3 TXNIP IL6 PMC9707336__F6 M6A methylation profiles of immune cells in type 1 diabetes mellitus MAX ECSIT SYK BAD FAS RAF1 TRADD CD14 RBL2 CYC1 PTEN CD19 TNF DAO CD37 NLK MDM2 GRB2 TRAF2 PMC9707336__F5 M6A methylation profiles of immune cells in type 1 diabetes mellitus MAX FAS TRADD GRAP IRF9 CD14 KL NLK TNF DAO FLNA PMC5159669__F7 Proposed models of two separable mTORC1 pathways RHEB TSC2 TSC1 FLCN PMC7503842__F2 Aberrant Wnt signaling favors disease progression in leukemia CDH2 FOXM1 SIX1 CD27 COX2 TNLG8A BMP4 CD82 MSC MTOR AXIN2 PMC7503842__F1 Wnt signaling pathways JUN APC GSK3B LRP5 LRP6 ARHA NLK RAC1 CTNNB1 PMC9552419__F9 SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain CCL11 CCL3 CCL7 TRPV1 CCL4 CCL2 PMC8743668__F2 Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma CDK8 STAT3 LRP6 PMC6273223__F2 Genistein (0.01–10 μM) stimulates breast cancer cell proliferation acting through the classical genomic ER pathway and/or through the fast, non-genomic GPER1-mediated pathway HBEGF EGFR GPER PMC7243790__F3 Chloroquine (CQ) and hydroxychloroquine (HCQ) suppress DNA sensing by the cGAS-STING pathway and Toll-like receptor (TLR) signalling TLR9 AIM2 IRF3 IRF7 IL6 TNF IL1B PMC8906734__F1 FKBP51 associates with amino acids and polyamine biosynthesis pathways RHEB TSC2 TFEB PMC4134342__F2 Sortilin, a novel APOE receptor implicated in Alzheimer disease APOE LDLR PMC3716523__F4 TGFB signaling pathway TF SMAD2 SMAD4 PMC7662576__F4 Host targeted drugs with potential use for Coronavirus disease-19 and their proposed mechanism of action CD14 MTOR JAK1 PMC4470864__F6 Pentose phosphate pathway (PPP) is associated with several cancer- and cell-proliferation-related signalling cascades F2 ATM TIGAR PMC5023176__F13 Cytokine Signalling Network for the Regulation of Inducible Nitric Oxide Synthase Expression in Rheumatoid Arthritis STAT1 PMC2786808__F8 Pivotal role for glycogen synthase kinase–3 in hematopoietic stem cell homeostasis in mice TSC2 TSC1 APC PTEN MTOR PMC4092039__F2 G-Protein Coupled Receptors Engage the Mammalian Hippo pathway through F-Actin LATS1 LATS2 RHO PMC4092039__F1 G-Protein Coupled Receptors Engage the Mammalian Hippo pathway through F-Actin LATS1 LATS2 CRB3 AMOT SCRIB PMC6933613__F8 Schematic diagram of IL-17A induces excessive autophagy via Src-PP2B-mTOR pathway in neurons under ischemic condition IL17RC PLCG1 MTOR SRC PMC8284339__F4 Integrative Analysis of Human Macrophage Inflammatory Response Related to Mycobacterium tuberculosis Virulence CXCL9 IL10 TNFRSF14 TNFRSF9 TNLG7A CXCL2 IL15RA CXCL10 CXCL3 TNFRSF18 CXCL11 IL24 PPBP CCL21 CXCR5 CCL8 TNFSF10 CCL17 PMC3045562__F1 Neural pathway for habituation in response to odors TG MB PMC3036164__F8 Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis EDN1 EDNRA EDNRB HAND2 PMC8796266__F1 Therapies for immune-related adverse events associated with immune checkpoint inhibition: from monoclonal antibodies to kinase inhibition CXCL9 CXCL11 BTK CXCL13 BCR CCL26 LYN MTOR CXCL10 EIF4E PMC3228010__F1 Signaling pathways of sunitinib and sorafenib cardiotoxicity BAX BAD RAF1 EEF2 MTOR PMC2939393__F1 The Fe-S biogenesis proteins, ISCA and C1orf69 (Iba57 homologue), may impact heme synthesis by affecting the production of succinyl-CoA, a substrate of heme synthesis PDC FES ALAS2 FECH PMC8371345__F1 Thyroid hormones and the potential for regulating glucose metabolism in cardiomyocytes during insulin resistance and T2DM CD36 HEL-S-5 PC PMC3204078__F5 SHP-1 activation and modulation on ghrelin signaling to Akt MLST8 RICTOR MTOR PMC3503557__F5 Network and pathway structure for biologically informative priors in the cancer drug response data study CDC2 BAD SHC1 BRCA1 ERBB2 CDK2 MTOR SRC CREB1 PMC10940682__F6 N-myristoylation is involved in the regulation of multiple cellular signal transduction pathways ZAP70 NMT1 LAT NKD2 APC IRF3 MTOR MYD88 BTK PLCG1 BCR TLR4 LYN LCK PMC10940682__F8 S-prenylation is involved in the regulation of multiple cellular signal transduction pathways CDC42 RHEB TRIM31 MLST8 TIAM1 MAVS RIN1 RHO GRB2 MTOR PMC3598339__F4 Network related to cell cycle and cell death in islets cultured at 23 mM glucose concentration NINJ1 TJP1 CLDN3 SDC4 MYC ADNP MPO HMOX1 QK3 CASP4 NPM1 APP KLF10 UBQLN2 NTN1 STAT2 PRNP FABP4 CD55 CASP8AP2 CYB PHGDH PEMT LIPE BCL2 TPP2 EP300 ADAM10 LCN2 FADD ELF3 PMC7287162__F7 Key components of the melanogenesis signaling pathway MC1R SOX10 PMC6933397__F5 Molecular mechanism by which NKILA regulates osteogenesis HDAC2 PMC10940682__F4 S-palmitoylation is involved in the regulation of multiple cellular signal transduction pathways STAT3 CGAS FAS EGFR APC LRP6 FLJ10842 PTEN IRF3 CTNNB1 PCSK9 HRAS RORC SCRIB GRB2 PMC8236581__F1 Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation APC LRP5 LRP6 ARHA CTNNB1 PMC6118308__F1 Progression and environmental sensitivity of C HOXB5 EGF PNP INSR EGFR PTEN GRB2 EML1 CTNNB1 PMC3938256__F1 Genetics of lymphatic anomalies GATA2 VEGFC KIF11 HGF RAF1 PTEN MTOR IKBKG PROX1 FOXC2 CCBE1 FLT4 SOX18 PMC12065391__F2 Inflammatory signaling pathways involved in MDS and associated therapeutic targets TLR1 GSDMD NLRP3 TIRAP CD33 S100A8 IRAK1 S100A9 IRAK4 MYD88 PMC4871122__F1 Copper transport and regulation in Schizosaccharomyces pombe SCO1 COX17 HEL-S-44 PMC7057456__F3 Visualization of identified KEGG Cell Cycle pathway routes CDC20 PCNA SMC3 APC SMAD4 ORC3 SKP2 ORC2 RAD21 CDK7 E2F4 CDC45 CDK2 MDM2 PMC5067249__F1 Schematic representation of the classic, alternative, and neural cholesterol clearance pathways of bile acid synthesis CYP8B1 CYP7A1 CYP46A1 CYP7B1 CYP27A1 PMC4433279__F4 Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma ROR1 PTEN MTOR PMC2672887__F1 Model for the regulation of type 1 interferon signalling by filamin B ISG15 RAC1 PMC3598339__F3 Network related to lipid metabolism in islets cultured at 23 mM glucose concentration CDC42 BAX PPARG BAD CYCS FABP4 HMGN1 SFRP1 APOA2 NR1C1 PCSK7 BCL2L2 ALDOB BCAP31 PARD3 CYFIP1 ERRFI1 PARD6B LIPE BCL2 HEL-S-1 PMC5795989__F1 BMP-triggered signalling pathway and major regulators TF BAMBI SMAD1 SMURF1 DKFZp781O1323 SMAD6 SMAD4 HEL-S-28 RHO SMURF2 PMC3598339__F2 Pathway analysis identifies a network of genes related to lipid metabolism in islets cultured at 5.6 mM glucose concentration WNT10B TCF12 TMEM97 PTN SCD SREBF2 AACS PTEN FABP4 STARD4 TNF SNAP91 CDC34 INSIG1 PCSK9 ACSS2 ATP6V1E1 PMVK EP300 SGTA PMC6915017__F6 CD28 regulates blast thoracic exposure-induced oxidative stress and apoptosis in brain tissue in mice via the PI3K/Nrf2/Keap1 signal pathway IL1B HEL-S-44 PMC3370396__F6 NSAIDs perturbed genes related to thrombosis, fibrinolysis, and PAR signaling TF PLAT APC PLG PMC7023504__F5 Mitochondrial redox signaling as essential part of branched-chain keto-acid- stimulated secretion of insulin IVD MCC HEL-S-44 PMC10525998__F10 Transcriptomic Analysis of Light-Induced Genes in Nasonia vitripennis: Possible Implications for Circadian Light Entrainment Pathways NPAS2 CRY2 PMC7251695__F1 LncRNAs regulate chemoresistance through apoptosis FAS MTOR CTNNB1 FADD PMC8647006__F1 Regulatory switches, reinforcement, and redundancy in DSB repair pathway choice BARD1 SMARCAD1 BRCA1 RNF168 RNF8 PMC6468910__F4 ER stress and chemo-resistance: Role of inositol-requiring enzyme 1 alpha (IRE1), activating transcription factor 6 alpha (ATF6), and glucose-regulated protein 78 (GRP78) PDIA5 BAD CDK6 MTOR BIK CDK4 PMC7251695__F3 LncRNAs regulate chemoresistance through cancer cell stemness KLF4 SOX9 SOX2 CTNNB1 PMC7014277__F3 Role of protein phosphatases in the DNA damage checkpoint deactivation ATR H2AX ATM PLK1 PMC5617549__F1 Molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer PFKFB4 F2 PMC5617549__F3 The molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer MAPK14 SLC2A3 HIF1A PMC6815035__F5 The miRNA–mRNA interaction networks containing eleven lipid metabolism or deposition related pathways ACOX1 PRKAA2 SI PRKAG2 FADS2 ELOVL1 CAMKK1 PLD4 PMC2853417__F5 Differentially expressed genes in the TGFB signaling pathway NR1i1 BMP2 TLX2 GSC NODAL RUNX2 RUNX3 PMC6815035__F7 MicroRNAs and their regulatory networks in Chinese Gushi chicken abdominal adipose tissue during postnatal late development MYLK2 PDGFRA PMC6815035__F6 MiRNA–mRNA interaction networks containing five cell proliferation and differentiation related pathways KLF2 SGK1 ERBB4 FST PDGFRA PRKAA2 NTRK2 PRKAG2 BMP5 PMC7540151__F2 Apoptosis by miR-187 CRMP1 FGF9 BCL2 CYP1B1 DKK2 BCL6 LEF1 AXIN2 CTNNB1 PMC6696099__F1 Proposed targeting approaches involving ACSL isoenzymes in cancer ACSL1 ACSL3 HEL-S-5 FACL4 PMC9273593__F6 Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications CXCR3 HGF GLS CXCL1 IL1B PMC7540151__F3 EMT by miR-187 S100A4 PTK6 SMAD2 NT5E ZEB2 SOX4 PMC5799178__F7 p38 mediates the transcription and the translation of E-selectin by modulating miR-146a and miR-31 GATA2 TRAF6 IL1B PMC7762471__F7 Mechanism underlying ISO’s anti-HCC effects BAX MTOR ATG5 PMC6219034__F10 PRRSV-induced G2/M cell cycle arrest in MARC-145 cells WEE1 MYT1 CCNB1 PMC5487699__F2 Regulation and execution of the autophagosomal-lysosomal degradation pathway ATG10 ATG3 PINK1 ATG12 LRRK2 ATG5 PMC8767971__F1 COVID-19 and Panax ginseng: Targeting platelet aggregation, thrombosis and the coagulation pathway PPARG KLK4 KEAP1 CCL3 CYCS PIK3R1 CCL5 CCL2 CXCL8 IL6R MAPK3 MYD88 ALB HMOX1 NGF STAT1 BCL2L1 F8 FDPS CREB1 GGPS1 CASP9 CSF2 PLG NTRK2 VEGFA TNF CXCL10 FOS IRS1 MVK CEBPA HMGCR IFNAR2 PMVK MVD BCL2 ADAMTS13 FDFT1 GRB2 BDNF SIRT1 TGFB1 IL2RA INS CSF3 BTK PLAT F2 TLR4 F3 IL18 IL2 TLR7 MX1 ISG15 OAS1 IFNA1 OAS2 KNG1 IL1B SERPINC1 IL10 JUN SQLE IL4 IL17A MMP9 PTGS2 IL6 NR3C1 FGF2 HEL-S-162eP CASP3 NFKBIA NFE2L2 JAK1 IFNB1 CD8A PF4 PMC2853417__F7 Differentially expressed genes in the estrogen receptor signaling pathway HDAC3 PELP1 DDX5 CARM1 IGFBP1 NR0B2 TBP PMC5355296__F2 Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase ATF3 EGR1 CREB5 TXNIP IL6 GADD45A PMC2853417__F6 Differentially expressed genes in the ERK/MAPK signaling pathway CRK STAT1 MOS PIK3CD GRB2 RAPGEF4 PMC2873055__F9 ACBD3-mediated signaling pathway and cellular regulation ACBD3 PBR NUMB PRKAR1A PMC7905525__F2 Signaling pathways associated with AQP5 in cancer EGFR SMAD2 CTNNB1 AQP5 PMC10179314__F1 PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis EGF HGF EGFR MTOR VHL PMC5840025__F9 Cell-specific requirements for STAT proteins and type I IFN receptor signaling discretely regulate IL-24 and IL-10 expression in NK cells and macrophages STAT3 STAT1 STAT4 PMC10885697__F2 MAPKs signaling is obligatory for male reproductive function in a development-specific manner EGFR SRC PMC12056752__F1 RAS signaling pathway involves small GTPase switch proteins, NRAS, and KRAS CBL NF1 GRB2 KRAS GAB2 PMC12056752__F2 MicroRNA Signatures: Illuminating Minimal Residual Disease Monitoring in Juvenile Myelomonocytic Leukemia - A Review RAN AGO1 AGO2 PMC4524120__F10 Proposed mechanism for the male-specific heart phenotype in insulin-resistant Pcyt2+/− mice CD36 PC PCYT2 PMC7900570__F1 Growth Hormone Signaling Pathway with highlighted Glucose Uptake micropathway STAT3 STAT1 IGF1 IGF1R PTPN6 GHR IGF2 IRS1 PMC7900570__F2 Node activation of Growth Hormone Signaling Pathway for gastric cancer sample GC.11_S19_R1_001 from STAT1 IGF1 IGF1R PTPN6 GHR IGF2 IRS1 PMC8403095__F7 Higher-order assemblies in immune signaling: supramolecular complexes and phase separation ZAP70 LAT GRB2 LCK PMC11731478__F1 Metabolic pathways of riboflavin in E RPIA TNLG7C PMC8403095__F1 Higher-order assemblies in immune signaling: supramolecular complexes and phase separation FAS MAVS MAL IRAK1 IRF3 IRAK2 IRAK4 MYD88 BCL10 BCR TLR4 IL1B FADD PMC5905998__F1 Spatial alterations of De Novo purine biosynthetic enzymes by Akt-independent PDK1 signaling pathways PAICS ASL MTOR HEL-S-70p PMC7824032__F1 Methylglyoxal and methylglyoxal pathway in cell response to oxidative stress HEL-S-162eP MAL GLO1 PMC8819539__F1 Periodontal Ligament Stem Cell-Derived Small Extracellular Vesicles Embedded in Matrigel Enhance Bone Repair Through the Adenosine Receptor Signaling Pathway PCNA BCL2 FGF2 PMC9563402__F2 MAPK Signaling Pathway in Oral Squamous Cell Carcinoma: Biological Function and Targeted Therapy JUN MAP3K7IP1 EGFR CXCL1 CXCL2 PMC9602304__F2 Emerging Role of MicroRNAs and Autophagy Mechanism in Pancreatic Cancer Progression: Future Therapeutic Approaches ATG101 ATG10 ATG3 ATG16L1 ATG12 ULK1 MTOR PMC9602304__F1 Emerging Role of MicroRNAs and Autophagy Mechanism in Pancreatic Cancer Progression: Future Therapeutic Approaches RAN AGO2 MT4 DROSHA PMC10178712__F5 RNA-sequencing analysis revealed the role of trimethylamine-N-oxide (TMAO)-mediated signaling in vascular dementia S100A8 MMP3 CCL4 WNT9B LCN2 CCL2 SPP1 CYBB ATP2A1 PMC3749870__F10 CD25 and CD69 induction by A4B1 outside-in signalling requires TCR early signalling complex proteins LAT CD69 VAV1 LCK PMC6509174__F6 Wnt/Beta-catenin signaling pathway regulated by PARG gene silencing during BaP-induced lung cancer PARG APC GSK3B CTNNB1 PMC6375548__F6 Alternative (backdoor) androgen production and masculinization in the human fetus HSD3B2 SRD5A2 HSD17B3 CYP17A1 CYP11A1 HSD3B1 AKR1C2 PMC4801721__F1 Methionine cycle and transsulfuration pathway HEL-S-61p PMC3751638__F3 METH-regulated genes in METH-pretreated rats KRT1 STAT3 SERPINF2 CPB2 PGR LNX2 IGFBP1 NR4A3 FOXA3 QSCN6 NPBWR2 ANP32E AMOT HSF1 RIMS2 HABP2 MYCBP SPAG5 UBC STAG3 MMP10 PLG AIP S100A2 JAM3 IGSF5 SPDY1 CLCN1 CD44 SRPK3 CEP152 PARD3 PLAG1 BMP2 BCL2 NPB CEP55 LAMA3 PMC6375548__F1 Alternative (backdoor) androgen production and masculinization in the human fetus SRD5A2 HSD17B3 HSD17B6 CYP17A1 CYP11A1 HSD3B1 HSD17B2 AKR1C2 AKR1C1 AKR1C4 PMC7211589__F1 This figure illustrates the differential glucose metabolism in a healthy macrophage and in a COVID-19-activated macrophage PDC AANAT ASMT MTOR PMC6396666__F3 Protein–protein interaction networks.Notes: Upexpression genes were analyzed and constructed a network KIF15 RCC1 HELLS CDC20 UBE2C ZWINT BLM FBXL7 MYLK TACC3 SPAG5 STIL CCNB1 TAC3 POLE2 CHAF1A ECT2 FOS FGF2 PTTG1 IGF1 AURKB GINS2 MCM5 MCM2 PMC5357538__F2 Wnt, Hedgehog, and Notch canonical signaling pathways SUFU APC SHH IHH SMO TEF PMC6691912__F1 EV production procedure.Exosomes, 50–150 nm, are initially formed by a process of inward budding in early endosomes to form multivesicular bodies CD81 CD9 CD63 PMC2951839__F1 Lower Succinyl-CoA:3-ketoacid-CoA Transferase (SCOT) and ATP Citrate Lyase In Pancreatic Islets of A Rat Model of Type 2 Diabetes: Knockdown of SCOT Inhibits Insulin Release In Rat Insulinoma Cells ACAT1 ACAT2 PC PMC8166871__F7 LIRCP-regulating network that connects autophagy and carcinogenesis PRLR PRKD3 GABARAP STAT3 TECPR2 ABCC1 KEAP1 TTI1 SMAD4 UCP1 ERN1 ADRBK1 EPHB2 DKFZp762B153 TP53INP2 ALK CACNA1H NCOR1 KL TBC1D7 KDR MCOLN1 MYH1 TRPM8 TBC1D15 TPP1 IRS1 TSC2 RICTOR SPNS1 PGRMC1 TWEAK UGCG CRTAM HSPG2 MYH6 F7 CAPN10 PRKCB TGFBR1 RHOT1 TLR4 SGPP1 NOD2 GPLD1 EPHA3 ATG5 VPS16 NPEPPS LRRK2 RRM2 SUPT20H COPA ARHA HEL-S-30 HEL-S-34 PHGDH PDGFRA VPS39 IFNB1 PCDH17 PIK3C2A SKP2 SLC16A7 NLRP3 SPHK2 RAB3GAP2 DNASE2 PIKFYVE SPG11 UVRAG LDHB PICALM NLRC4 EIF4G1 MAP1LC3C EXOC2 SORT1 CBFB HAT1 PTCH2 IFNAR1 MTMR8 MTMR9 AMBRA1 OATL1 STBD1 CXCR4 CYBB TET2 ATR ENO2 MTMR3 KIAA0226 EGFR BRAF MTOR GRID2 SNX4 ATM CHUK OPTN PFKM RPTOR MAP1S PLD2 CLCN3 ATG2B PDE5A NAA25 EFL1 ZFYVE26 ATAD3A TECPR1 PPP1R13L SNX30 ATG9A PRKDC TBC1D17 PFKL PMC9100033__F1 Disorders of the Calcium Sensing Signaling Pathway: From Familial Hypocalciuric Hypercalcemia (FHH) to Life Threatening Conditions in Infancy CASR AP2S1 GAL PMC4803814__F1 Ras MAP kinase pathway RASGRF1 PIK3CA RGL3 RAF1 SHC1 MAPK13 SOS1 RASGRP3 RPS6KA2 PIK3CD RPS6KA1 BRAF SHC2 RCE1 SHC4 KSR2 RASA2 ICMT RASAL1 NRAS DUSP16 SHC3 RASAL3 MAPK1 RASGRP4 JUN ETS2 KSR1 KRAS FOS ARAF HRAS RASA3 RAPGEF2 RAPGEF1 SOS2 RPS6KA3 MAP2K1 GRB2 PMC8495134__F1 Epilepsy in the mTORopathies: opportunities for precision medicine STRADA RHEB TSC2 TSC1 NPRL2 TBC1D7 C16orf35 PTEN DEPDC5 MTOR PMC2645305__F3 Airway Smooth Muscle Growth in Asthma RHEB TSC2 GSK3B ELF2 MTOR EIF4E PMC2276341__F3 Network analysis of target genes PIGC SFRP4 TCF12 PMF1 TPO Meflin NEUROD2 PMC9671114__F6 Changes and significance of gut microbiota in children with focal epilepsy before and after treatment NAGA BAD MAL SI PMC2194080__F1 Proposed mechanism of CD4+ T cell priming after Leishmania major infection EPCAM MYD88 PMC8231510__F3 CUT Domain Proteins in DNA Repair and Cancer LIG1 MPG NEIL2 PMC8231510__F2 CUT Domain Proteins in DNA Repair and Cancer KEAP1 SESN3 PTEN SESN1 GRB2 NOX4 RAC1 PMC7063158__F1 Schematic diagram for T cell activation and mechanism of IP3 activation PC NACA PMC8546182__F1 Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease P2RX7 SDHA PMC3538588__F8 Systems Biology Approach Reveals Genome to Phenome Correlation in Type 2 Diabetes LTBP1 IFNG RBX1 FST SMAD6 SMAD4 SKP1 NODAL ARHA PITX2 PMC3759750__F2 Regulation of prosurvival and apoptotic pathways by ER stress BAX CASP9 EDEM1 CASP3 ATF4 EIF2A XBP1 TRAF2 PMC4455918__F1 mTOR signaling pathway EIF4B MTOR EIF4E PMC86592__F9 LPS-induced signaling pathways leading to activation of transcription and spreading CD14 TRAF6 LBP MYD88 PMC9404696__F7 ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition ANGPTL8 GSK3B CTNNB1 PMC3267662__F2 IGF1R-IR/PI3K/Akt/mTOR pathway and its manipulation through diet IGF1 IGF1R MTOR PMC10609794__F2 The PRG4-CD44 axis in mitigating the pro-inflammatory and pro-fibrotic signaling pathways in DJDs TF CD44 NLRP3 SMAD2 SMAD4 PMC208733__F1 Regulation of the Foxa and Foxo transcription factors through PI3-kinase signaling FOXA1 PGC FOXO4 FOXO1 FOXA3 FOXA2 PMC6206292__F3 Diagram of carbohydrate metabolism pathways with their related DEGs (differentially expressed genes) and DAMs MT1A SI CS MIP PMC6206292__F5 Brief diagram of amino acid metabolism pathways with related DEGs and DAMs AANAT ASMT HEL-S-61p AFMID PMC11853609__F9 Schematic model of the mechanism by which PHF8 promotes malignant phenotypes and immune escape of KRAS- or BRAF-mutant CRC cells BRAF IRF1 IRF7 TAP1 CCL5 HLA-B KRAS HLA-A PMC3731360__F6 Role of CTLA4 in the Proliferation and Survival of Chronic Lymphocytic Leukemia ZAP70 STAT1 VAV3 BCR NFATC2 BCL2 CTLA4 MYC PMC6034754__F4 MicroRNA molecular profiling identifies potential signaling pathways conferring resistance to chemoradiation in locally-advanced rectal adenocarcinoma BCR MAK SMAD2 PIR SMAD6 MMP20 ZEB2 BCL6 ELMO2 PMC2438299__F6 Regulation of G1/S transition by the Cdh1/APC-Skp2-p27 cascade in colon cancer Cdh1/APC is critical in regulating Skp2-p27-cyclin E/CDK2 axis, resulting in averting abnormal entry of S phase CDC2 CDK2 SKP2 PMC4725591__F2 BMP signal transduction SMAD1 DKFZp781O1323 SMAD6 SMAD4 PMC8239905__F3 COVID‐19‐related coagulopathy: A review of pathophysiology and pharmaceutical management TF PMC7490227__F10 Silencing of S100A4 downregulated the PI3K/Akt/mTOR pathway, enhanced autophagy, and promoted wound healing of rabbit cornea after alkali burn FGF5C MTOR PMC6496459__F3 Differential regulation and effects of glycolysis induction in GM-DCs upon stimulation over time CD40 CD80 FAS CCR7 HIF1A MTOR PMC6496459__F2 Cellular metabolism networks PDK4 HEL-S-62p HEL-S-133P C2 FASN MPC1 PDK3 PDK2 PMC9315842__F2 Ferroptosis defense pathways GPX4 DHFR GCLC DHODH PMC8421956__F3 Basic science of optic nerve regeneration STAT3 CNTF TSC1 IGF1 LIF PTEN SOCS3 MTOR PMC5572616__F1 Effect of the Hh signaling pathway on the regulation of proliferation and differentiation of SSCs in mammals MAX GDNF SUFU DHH PMC8507550__F2 The Hedgehog Pathway in Cholangiocarcinoma CDH2 PLK2 SOX2 SMO PMC8507550__F1 The Hedgehog Pathway in Cholangiocarcinoma SUFU SMO GLI3 PMC11674716__F14 Diagram of red KEGG of Non-alcoholic fatty liver disease SOCS3 PMC11674716__F13 Diagram of red KEGG of AMPK signaling pathway FAS POC1A CD36 MTOR PDK2 INS RHEB TSC2 EEF2K NR2A1 INSR CIDEA F2 CFTR PMC11674716__F12 KEGG network diagram of the PPAR signaling pathway LPL UBC HEL-S-28 PLTP CPT2 PMC3551464__F1 Control of cell adhesion during neuronal migration CDH2 DAB1 SIAH2 ASTN1 RAP1A ASTN2 RELN PMC10375449__F8 Cyclovirobuxine D pretreatment ameliorates septic heart injury through mitigation of ferroptosis STAT3 SLC3A2 GPX4 SLC7A11 PMC11674716__F11 WikiPathway outline of burn-wound healing NOS2 TGFB1 LAMA1 PRODH2 EPO VEGFA ACTA1 TNF PECAM1 HBEGF COL1A1 GJA1 CCND1 PMC7791174__F7 Illustrations of TRPV6 as a critical regulator in osteoclastic bone resorption IGFBP1 IGF1R TRPV6 PMC7727543__F1 Key mutations in gene categories represented in MDS/MPN overlap syndromes TET2 CBL SF3B1 RUNX1 NF1 BAP1 ASXL1 PTPN11 PMC6899977__F3 The carcinogenic mechanisms of six major microorganisms TH STAT3 SMO PMC3764601__F4 The meiotic recombination pathway in C MSH4 RAD50 RAD51 SP1 MRE11A SP4 SP3 SP7 SP2 SP9 RTEL1 SP5 PMC11839971__F1 circ0066187 promotes pulmonary fibrogenesis through targeting STAT3-mediated metabolism signal pathway C6 STAT3 BLM RTCA PMC11956896__F3 The regulatory effects of PCSK9 in T cells and tumor cells PCSK9 TH TLR4 LDLR NFATC1 PMC7072930__F2 Therapy for fibrodysplasia ossificans progressive (FOP) SMAD1 DKFZp781O1323 SMAD4 ENPP2 MTOR PMC11956896__F1 Mechanism by which PCSK9 regulates lipid metabolism PCSK9 CD36 LDLR PMC4449624__F1 Metabolic Alterations Induce Oxidative Stress in Diabetic and Failing Hearts: Different Pathways, Same Outcome UCP2 TG UCP3 PMC5004130__F6 Role of IL-17 Pathways in Immune Privilege: A RNA Deep Sequencing Analysis of the Mice Testis Exposure to Fluoride CRP RELA IL4 CCL1 CP PMC4335171__F1 Death and dessert: Nutrient signalling pathways and ageing PTEN IGF1R IGF2 IRS1 PMC10380638__F5 Schematic presentation of low-dose IR-induced immune effects in the spleen of mice, according to Cho et al IL5 PMC7427859__F5 Differentially methylated genes of mTOR signaling pathway at CG (a) and CHH types (b) SGK1 GSK3B PTEN FLCN MTOR RHO SKP2 DEPTOR IRS1 EIF4E RHEB TSC2 RICTOR GRB10 RS1 SESN2 RNF152 PMC3270467__F1 Putative galanin-mediated neuronal pro- and antinociceptive mechanisms in the dorsal horn of the spinal cord GAL GALR1 TRPV1 GALR2 PMC6294998__F2 New therapeutics based on emerging concepts in pulmonary fibrosis CXCL12 IL10 TGFA IL13 EGFR CCL2 PMC4560409__F8 Neoglycoconjugate Containing the Human Milk Sugar LNFPIII Drives Anti-Inflammatory Activation of Antigen Presenting Cells in a CD14 Dependent Pathway SYK CCL22 RAF1 TLR4 CD14 IL4 MMP9 PMC5348798__F3 Cdk5 takes part in DDR through STAT3 pathway STAT3 CDK5 MYC CCND1 EME1 PMC8504955__F3 Large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain NDUFB8 HEL60 ND4L ENO2 COX7A1 IDH3B NDUFAF2 COA3 NDUFS6 HEL-S-32 AGL GAD2 MDH2 PFKM COXFA4L2 ACO2 COX5A COA7 SDHA SDHB OGDH PFKP ZNF183 ENO1 PFKL SDHC PMC10892304__F6 Protein–protein interaction (PPI) network in biosynthesis of plant hormones and signal transduction pathways EBF2 BAK1 PMC3867948__F4 Death receptors and the extrinsic pathway of apoptosis FAS TRADD FADD PMC8276676__F3 Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma IL17RC C2 TRAF6 PMC10515252__F4 m6A modifications interact with the CRC inflammatory microenvironment EPHA2 SOCS2 IGFBP2 METTL3 VEGFA PMC8276676__F4 Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma IL17RC C2 TRAF6 TNF PMC3603502__F10 Redox regulation of signaling pathway leading to T-cell activation/proliferation HEL-S-92n LAT CCR7 PMC9221329__F1 Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review CDH2 STAT3 ZEB2 TNF CTNNB1 PMC8230587__F3 The Interplay of Alpha-Synuclein and Sphingolipid Signaling in Parkinson’s Disease HDAC1 PHB2 SPHK1 BDNF HDAC2 PMC11655208__F4 Circadian regulation of drug response in mental disorders PPARG TNC CA12 CA13 AMH DDC PMC6445936__F7 Highlights of this study FUT8 BCR CD69 PMC9191825__F2 Human‐host transcriptomic analysis reveals unique early innate immune responses in different sub‐phenotypes of COVID‐19 JUP MAL FES SKI PMC9191825__F4 Human‐host transcriptomic analysis reveals unique early innate immune responses in different sub‐phenotypes of COVID‐19 STAT3 IFNE IL10 C7 MAVS STAT2 CFD IL2RA IRF3 IRAK2 CS TRAF6 KRAS IL1R2 NLRP1 NLRP3 TLR4 C9 ACE2 PMC9213771__F7 Identification of two lipid phosphatases that regulate sphingosine-1-phosphate cellular uptake and recycling GOLPH3 UGCG SGPL1 CERS2 SPHK1 PLPP3 SLC35A2 SGPP1 TM9SF2 LAPTM4A AHR TMEM165 B4GALT5 A4GALT PMC7137032__F2 Current paradigm of asthma endotypes and related therapies IL25 TSLP IL33 PMC9643007__F10 Stromal contributions and potential therapeutic agents MPG GINS2 BRAF KIT BCL2 ATM SRC GINS1 GINS3 GINS4 PMC3741135__F9 Sirt1 Inhibits Akt2-Mediated Porcine Adipogenesis Potentially by Direct Protein-Protein Interaction FAS GSK3B SIRT1 PMC9409235__F4 mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease MTOR PMC5045425__F4 Gene expression profiling of normal thyroid tissue from patients with thyroid carcinoma TSPAN1 KLK4 HBEGF JUND TFRC CCNL1 HLA-G BMP3 ACCS PTGS2 TEF FOS PMC8652287__F2 Biological Adaptations of Tumor Cells to Radiation Therapy SIRT3 KNS2 MPC1 EIF2A PMC8067192__F4 Network analysis performed using ingenuity pathway analysis (IPA) DBP GSK3B APMAP CD5 IGFBP4 IGF1R CCL2 ORM2 MPO C1QTNF4 IFNG FANCD2 CLU SAA2 SEC16B NR1H3 STAR TCL1A RBP4 CLEC3B HAVCR1 APOF IDO2 HPR SAA4 PS1TP5BP1 PMC9409235__F3 mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease NLRP3 TXNIP FOXO1 ULK1 TLR4 TFEB TLR9 PTEN NR1C2 OSR1 PMC9409235__F2 mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease TG FOXO1 SQLE FASN CRTC2 FLCN PTEN IRS1 PMC7407646__F1 TLR4 signaling pathways activated in microglia during neuroinflammation RIPK3 HMGB1 CASP8 NLRP3 MLKL TLR4 CASP3 RIPK1 TRAF6 IL1B FADD MYD88 PMC11820109__F7 Cdk5-gated light signal SIK1 CDK5 PER2 GEM PER1 CRTC1 PMC7972864__F1 Proposed model of signaling pathway involved in FUC prevented 6-OHDA-induced ROS KEAP1 GCLM GCLC MAF PMC9643775__F2 New insights into iNKT cells and their roles in liver diseases CD40 CD80 FAS SIRPA CD47 PMC3126159__F4 Temporal regulation of apoptosis in SeV-infected cells by PI3K BAX TBK1 RIGI IRF3 APAF1 PMC7429975__F7 Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models MAX TH GEM SMO PMC4386721__F3 Signaling pathway map GSK3B PTEN PMC7744373__F5 Differentially phosphorylated protein Pathway enrichment analysis HEL114 CRK BAD VASP PXN F2 APC HEL-S-28 PTEN RHO SHE INS PMC4490461__F6 Schematic representations of mammalian homocysteine metabolism PMC3229968__F2 Deciphering the role of Nuclear FactorKB in cellular senescence ATM TRAF6 PMC3229968__F1 Deciphering the role of Nuclear FactorKB in cellular senescence LTB MAP3K7IP1 RELA RELB PMC3229968__F3 Deciphering the role of Nuclear FactorKB in cellular senescence RHEB TSC2 TSC1 PTEN MTOR SIRT1 PMC7947273__F4 Life Without Thyroid Hormone Receptor PRMT1 MSI1 GPR49 PMC5664959__F2 Molecularly Targeted Therapies for p53-mutant Cancers EGFR ARHA MTOR PMC6456454__F1 Inflammatory mediatorsA: Inflammatory mediators with mainly proatherogenic effects are mediated by interleukin-1(IL-1), interleukin-6 (IL-6), and tumor necrosis factorA (TNFA) through nuclear factor kappa beta (NFDB) signaling cascade CRP PTX3 TNF PMC3717800__F7 Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma BAD VASP BRAF HEL-S-28 PTEN ARHA SHE PMC4013649__F7 A20 on LPS signaling pathway CD40 TLR4 IRAK1 TRAF6 IRAK4 PMC2923453__F1 Molecular Pathways: Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma AMD1 SMS COX2 OAZ1 OAZ2 SRM SMOX PAOX OAZ3 MYC PMC3534787__F9 Vorinostat, an HDAC Inhibitor Attenuates Epidermoid Squamous Cell Carcinoma Growth by Dampening mTOR Signaling Pathway in a Human Xenograft Murine Model PI3 PTEN MTOR PMC4643408__F2 Signaling pathways associated with CRKL, GAB2, and FRS2.CRKL is activated by multiple types of cell surface receptors including integrin receptors upon binding to extracellular matrix (ECM), cytokine receptors, and growth factor receptors EGF HGF FRS2 CRKL GRB2 GAB2 PMC4119864__F3 Signaling epicenters: The role of caveolae and caveolins in volatile anesthetic induced cardiac protection CAV3 CSK SRC PMC7080238__F9 STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection CGAS NLRP3 IL1B PMC8080572__F1 Key signaling molecules in angiogenesis VEGFB VEGFC PIGF NRP1 NRP2 VEGFA PMC10853571__F6 Molecular mechanisms of tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin/norepinephrine reuptake inhibitors (SNRIs) and ketamine CAMK4 MTOR BDNF PMC9143160__F1 PD-1/PD-L1, MDSC Pathways, and Checkpoint Inhibitor Therapy in Ph(-) Myeloproliferative Neoplasm: A Review EGF PTEN KRAS PMC9515494__F8 Systemic tryptophan homeostasis SLC3A2 TPH1 IDO1 ULK1 TPH2 SLC7A5 SLC6A19 MTOR SLC16A10 ACE2 GPR142 SLC15A2 PMC10853571__F3 Molecular signaling schematic of cytokine hypothesis in the pathogenesis of MDD UCP2 STAT3 NLRP3 GSK3B TCF4 IL6 CTNNB1 PMC10853571__F2 The pharmacological mechanism of fluoxetine in astrocytes EGF EGFR PTEN SRC PMC6678550__F1 Potential signaling pathway between expression of bone morphogenetic protein receptor type II, HDL cholesterol, and vascular remodeling in pulmonary arterial hypertension BMPR2 PAH ABCA1 PMC9515494__F4 Systemic tryptophan homeostasis HEL-S-90n IDO1 KYNU KMO HAAO PMC5514982__F1 Caloric restriction, exercise and AdipoR pathway activate AMPK–SIRT1 and PPAR pathways, which may increase longevity in humans MTOR SIRT1 PMC7506548__F2 Non-canonical NFKB pathway NLRP12 TBK1 OTUD7B RELB TRAF3 TNF PELI1 TRAF2 PMC2581770__F3 TNFR and LTBR signaling pathways for NFKB activation LTBR RELA RELB PMC7506548__F1 Activation and regulation of canonical NFKB pathway TRADD TIRAP TAB3 IRAK1 TRAF6 IRAK4 MYD88 BCL10 TLR3 TLR4 TRAF5 TRAF2 FADD PMC7457231__F3 SMAD cooperation with different DNA binding partners LATS1 FOXH1 LATS2 SMAD2 SMAD4 GSC NODAL MIXL1 PMC4673661__F1 Osteocytes and Skeletal Pathophysiology TRANK1 SOST CTNNB1 PMC7457231__F6 Cancer cells can traverse the tumor suppressive TGFB bottleneck by accumulating mutations (“X”) that disable the signal transduction pathway ANGPTL4 CXCR4 KRAS PMC7457231__F5 Determinants of TGFB tumor suppression and its subversion in cancer SMAD4 KLF5 SOX4 PMC8205588__F1 Ferroptosis in Different Pathological Contexts Seen through the Eyes of Mitochondria STEAP3 GPX4 PMC7982543__F3 Pathological pathway of “Lipid-toxicity Inflammation” or “Dampness-heat Syndrome”—Insulin Resistance-Metabolic disease TLR4 UNK IL1B PMC5691648__F6 Predicted pathways deregulated during ZIKV infection SCEL HEL-S-99n CANX BCL2 AMFR ATF4 EIF2A XBP1 VCP TRAF2 PMC7457231__F1 TGFB–SMAD pathway in the basal and activated states CDK8 SMAD4 CDK9 PMC8558661__F10 Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-Alpha-activated COX-2-cPLA2-PGE2 Pathway BAX GC CLC ATG5 PMC8877534__F9 Sdy-1 Executes Antitumor Activity in HepG2 and HeLa Cancer Cells by Inhibiting the Wnt/Beta-Catenin Signaling Pathway GSK3B LRP5 LRP6 CDK4 CTNNB1 PMC3878444__F3 The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro CSF2RA BAD IL13 IRF1 PMC5640981__F3 Thyroid C-Cell Biology and Oncogenic Transformation RHEB CASP9 TSC2 BAD TSC1 SHC1 GRB2 PMC3878444__F2 The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro SLC11A2 JUN CLEC7A PPIF JUNB SDC4 GLRX ENPP1 ERC1 ZMYND11 PIM3 IRAK3 WTAP TNIP3 TRIM6 PMC3878444__F4 Upstream regulators and their target molecules in datasets as identified by Ingenuity Pathway Analysis (IPA) CD40 TNFAIP3 CCR5 MARCKS CCL5 BTG3 CDK6 SNX4 CCR7 PSMB10 RGS1 IL1B BIRC3 NOS2 IL10 SAMSN1 SELL IL13 IL4 IRF1 CXCL2 CD40LG TNF FOS NFKB1 CDKN1B IFNB1 BIRC2 CCL20 PMC3157228__F7 Scheme for changes in the molecular pattern of inflammatory signaling, antigen processing, and presentation in attacked myofibers STAT1 IFNGR2 IFNGR1 MHC2TA PSMB8 PMC5035969__F1 Schematic presentation of the N-linked core oligosaccharide structure EDEM3 EDEM1 EDEM2 PMC10419312__F3 Agents to target macrophages in CTD-ILD S100A4 IL33 SMAD4 CTNNB1 PMC10419312__F2 Macrophages in CTD-ILD CCL18 CCL2 TNF SDC2 PMC3878444__F6 The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro CD40 TREM1 NOD2 PMC5563070__F6 Cell type-specific metabolism of T MAL INS CIT PMC9105721__F1 Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood Obesity PCSK1 LEPR POMC PCSK2 MC4R MC3R NPY NPY5R AgRP PMC7065375__F7 Part of the KEGG pathway “Focal adhesion” CRK JUN BAD VASP FYN HEL-S-28 PTEN ARHA GRB2 SHE PMC3717870__F4 Analysis of gene transcription in response to an acute bout of exercise identifies dysregulation of SMAD, CREB, and HDAC activity in LRT SKIL NR4A3 EYA1 POR MIDN GADD45B ATF1 PPARGC1A CREB1 CSRNP1 TPSAB1 FSTL3 ANKRD1 EGR1 MXD1 FOS SFRP1 SPRY2 ATF3 HBEGF SEMA3C BTG2 CDKN1A RHOB NAB2 HSPA4 DDIT3 BCL2 SERTAD1 EGR2 GADD45A PMC8745251__F1 Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles AKR1D1 CYP8B1 CYP7A1 HSD3B7 CYP7B1 CYP27A1 AKR1C4 PMC8745251__F2 Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles FGF8A ABCG5 CYP7A1 FGFR4 PMC7210752__F1 Proposed model for the regulation of pistil growth and ovule primordium initiation BIN2 PIN1 PMC8650509__F1 Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease PINK1 SNCA RAC1 PMC8650509__F4 Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease DUOXA2 NOXA1 NOX5 NOX3 DUOXA1 DUOX1 DUOX2 NOX4 PMC4812115__F5 Most correlated signaling pathway was the rheumatoid arthritis pathway (http://www.kegg.jp/kegg-bin/show_pathway?map05323) PTER IFNG CTSL CTSK CXCL2 IL6 PMC8296592__F8 EGFL6 regulates angiogenesis and osteogenesis in distraction osteogenesis via Wnt/Beta-catenin signaling EGFL6 BMP2 VEGFA RUNX2 CTNNB1 PMC3521791__F6 Part of the top canonical pathway affected by in vivo LPS administration into the human lung SOCS1 RAN TIRAP TLR9 IRAK1 IRAK2 TRAF3 TRAF6 IRAK4 MAPK3 MYD88 DOK1 MAPK14 TRAF4 MAP2K6 CREB1 MAPK1 IRF3 IRF7 MAP3K1 TNFAIP3 TRAFD1 BTK MAP2K4 TICAM1 TLR4 IRAK3 TLR8 NOD2 TNIP3 RIPK1 TLR7 NOD1 FLII MAP2K3 JUN TICAM2 TRAM1 IL1RL1 CD14 TLR5 CD44 NLRP12 TLR1 TLR3 NFKB1 RELA MAP2K1 MAP2K2 LBP TLR10 PMC6497364__F4 MiR‐125b‐protein and protein‐protein interaction network of differentially expressed genes, with particular focus on AHSG (fetuin‐A), FGF‐23, and TNFRSF11B (osteoprotegerin) TNFRSF11A LTA LTBR LAT TNF GNAS LTB AHSG RELA BIRC2 TNFRSF11B FGF23 BIRC3 PMC3589551__F2 Regulation of LTP induction in the hippocampus by NRG1-ErbB4 signaling through suppressing Src enhancement of NMDARs NRG1 ERBB4 SRC PMC2930670__F2 Iron redox cycling in aerobic iron metabolism TF FTH1 HP PMC11535355__F7 Proposed model IRAK1 IL6 TRAF6 TNF PMC5493774__F9 SUMO pathway plays a crucial role in IBD: model representation of importance of SUMOylation in intestinal health and disease NOS2 TSLP TNFAIP3 PMC5681992__F3 Schematic overview of the bile acid signaling pathways to the central nervous system FGF8A NTS FGFR4 FGFR1 FGFR3 FGFR2 PMC5681992__F1 Schematic representation of bile acid synthesis pathways in humans CYP8B1 CYP7A1 GCA CYP46A1 CYP7B1 CYP27A1 PMC3629761__F3 B-cell receptor (BCR) signaling pathway and potential targets SYK BTK BCR CARD11 LYN PMC9459608__F1 Kisspeptins and norepinephrine regulate different G-protein-coupled receptor signaling pathways LATS1 ADRBK1 LATS2 EGFR AMOTL2 KIRREL1 MTOR SRC PMC5578700__F1 Bon EPOtit! S1P-Mediated EPO Signaling Whets a Macrophage’s Appetite for Apoptotic Cells MFGE8 CD36 EPOR EPO MERTK PMC6158478__F2 Biochemical pathways of lysophosphatidic acid synthesis and degradation LPA PLD2 LPAR2 PMC8008022__F3 Apoptosis is triggered through two major pathways referred to as the intrinsic and extrinsic pathways HTRA2 PANX1 TRADD TLR3 TLR4 CASP3 RIPK1 ADAM10 BIK FADD PMC5703744__F1 Two major pathways in the cellular folate cycle DHFR SHMT1 MTRR HEL-S-61p HEL-S-70p MTR ADA PMC7853880__F1 Canonical Wnt/beta‐catenin signaling pathway JUN APC GSK3B LRP5 LRP6 MYC CTNNB1 PMC4449453__F1 Beyond Adjuvants: Immunomodulation strategies to enhance T cell immunity APC PMC7658481__F6 Pioglitazone effects on TLR and interferon (IFN) pathway TBK1 STAT2 IRF9 MAL IRF3 IRF7 TRAF6 MYD88 STAT1 IFNAR2 TLR4 USP18 IFNAR1 PIAS1 ISG15 PMC5610679__F1 Molecular events occurring in Alzheimer’s Disease (AD) following locus coeruleus (LC) norepinephrine (NE) loss and autophagy impairment FER APP MTOR PMC4777469__F1 Genes and miRNAs involved in the regulation of the intrinsic and extrinsic apoptosis pathway BAX FADD PMC6533856__F1 Leptin metabolism pathway STAT3 POMC SOCS3 AgRP PMC3062410__F2 Networks most highly represented by transcripts differentially associated with HuR after IR treatment MAX ECSIT EGF JUN FAS FCER2 EGFR TNF FLNA ITPKA RALB NF1 TRAF2 UBB PS1TP5BP1 ADA PMC2869512__F3 Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis CRP TF COX2 IL18 VCAM1 PMC7354440__F8 PEDV nsp15 antagonizes host antiviral response by degradating the RNA levels of TBK1 and IRF3 TBK1 RIGI MAVS IRF3 PMC6674748__F2 Signaling cascades in axon specification CDC42 TIAM1 MAP1B APC GSK3B NUMB HEL-S-28 PMC3489757__F1 New insights on the role of CD8+CD57+ T-cells in cancer TGFB1 KLRG1 IL2 PMC9504568__F10 1,25-Dihydroxyvitamin D3 Negatively Regulates the Inflammatory Response to Porcine Epidemic Diarrhea Virus Infection by Inhibiting NFKB and JAK/STAT Signaling Pathway in IPEC-J2 Porcine Epithelial Cells NR1i1 STAT3 STAT1 SOCS3 PMC9386495__F9 Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability LIPA IPP PMC8010076__F2 Clustering and pathway analyses of proteins quantified in EAE and CPZ PPARG STAT3 SEC61A1 PPIB CLIC1 DYRK1A HEL-S-21 FLNA AHSG HEL-S-99n HMOX1 SCG5 CLTA TPD52 HEL-S-44 PRDM1 SERPINA3 APOE SERPINA1 ARHGEF3 HEL-S-78p GFAP PTBP1 EPHX1 ALDH9A1 CP BAD RPL18 HEL57 SLC7A11 GPX1 UBN1 HADHB HEL-S-128m RBP1 ASPH HEL-S-108 ISG15 UBE2L3 PSMB8 ANXA1 hEMMPRIN CBX3 ITGAM HEL-S-130P DNAJB6 TCEAL6 NFE2L2 PSAT1 S100A9 PMC5995216__F2 Comparison of the LC3-conjugation pathway during canonical autophagy and Plasmodium-associated autophagy-related (PAAR) response ATG101 NBR1 ATG10 ATG3 ATG12 ULK1 ATG5 PMC5742324__F1 Glucose and glutamine catabolism provide tumor cells with biosynthetic precursors GLS HEL-S-133P LDHB MPC1 HLA-C PMC2277498__F3 Pharmokinetic Limitations of Antioxidant Treatment for COPD BAD TRADD RELA APP TNF TRAF2 FADD PMC8515183__F2 Interactions Between Pathogenic Burkholderia and the Complement System: A Review of Potential Immune Evasion Mechanisms C6 HEL-S-62p C2 PLG VTN C4A C4B_2 CP PMC4589488__F3 Schematic view of bench-to-bedside aspects of colorectal cancer epigenetics CDKN2A HEL113 TIMP3 ITGA4 BMP4 ID4 HLTF IRF8 SLC5A8 SFRP1 PMC5059177__F1 Pterin and monoamine metabolism TH DHFR PAH PMC7808935__F2 Counteracting CAR T cell dysfunction ATR KLRG1 ATM PMC9994446__F3 Developmental regulation of leaf venation patterns: monocot versus eudicots and the role of auxin SKP1 DAO PMC4682887__F1 Vaccines against Gonorrhea: Current status and Future Challenges TH GC IL1B PMC3642145__F2 FIP1L1/PDGFRA+ eosinophil signaling.FIP1L1/PDGFRA+ primary eosinophils express upregulated IL-5 receptor (IL-5RA) and JAK2/STAT5 pathway may be involved in FIP1L1/PDGFRA induced disease development(; ; ) IL5RA CCR3 PMC6827038__F5 Effect of Ad-Cyp8b1 on liver and intestine gene expression and mTORC1 signaling in HFD-fed mice FGF8A CYP8B1 FGF21 FGFR4 PMC9181511__F2 Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity CXCL9 IFNG CCL3 CCL7 IL2 FABP4 CCL4 CCL5 CXCL10 CCL8 CCL2 IL1B PMC8000248__F4 Non-coding RNAs regulating Notch Signaling ADAM17 PMC2606015__F9 Schematic view of the Vav family-regulated signaling pathways of DT40 B-cells SYK BTK VAV3 BCR RASGRP3 BLNK ARHA GRB2 SRC RAC1 PMC7995014__F1 Schematic illustration depicting the association of overnutrition/obesity/excess amino acids to angiotensin‐converting enzyme (ACE2) receptors leading to the hyperactivation of mammalian target of rapamycin (mTOR) MTOR ACE2 PMC3180573__F1 Targeting the Nrf2–Keap1 antioxidant defence pathway for neurovascular protection in stroke KEAP1 MAF SQSTM1 PMC11921618__F9 Schematic model illustrating the mechanism of TMEM176B inhibiting OC progression LR8 CCND1 CTNNB1 PMC11701242__F10 MTORC1 pathway by condensate MLST8 TSC2 DYRK3 MTOR DEPTOR PMC5885411__F3 Pathway analysis illustrating differential gene expression and association between gene nodes CENPF AURKA NEK2 KNTC2 CENPE CCNB1 CKAP5 LMNA PMC8327843__F2 Regulatory T cell infiltration in tumors: implications for innovative immune precision therapies CXCR3 CCL22 CCL28 CCR5 CCR4 CCL5 CCR10 CCR8 CCL1 CCL17 PMC4938192__F1 Steroid metabolism pathway AKR1C2 AKR1C1 CYP7B1 PMC12065540__F4 Upregulation and downregulation of active factors, mRNA, and signaling pathways during the ulcer healing process BAX TIMP1 PKNOX1 GPX4 DMBT1 PTEN SIRT1 PMC12065540__F1 Pathogenesis of Diabetic Ulcers MTOR TNF PMC8771101__F1 Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage LPL HEL-S-2 TLR4 C9 ATM IER2 IFIT2 ARG1 CXCL10 CD163 TMEM119 SPP1 PMC5676684__F6 Network of miR-93 and miR-21 with putative target genes of important signaling pathways from KEGG enrichment analysis SOS1 PIK3R1 GNG12 SMAD4 ATF2 SOCS3 CTBP2 INHBA MAP2K6 NF1 PRKCA BMPR2 CACNA1C ROCK2 SP1 TFDP1 CRKL APC NTRK2 CRK RAPGEF2 MAP3K5 BAD BMP8B EGFR AKT3 RPS6KA1 FBXW11 PHKA2 STK4 PPP2CA MEF2C CTNNB1 YWHAQ INSR TBL1XR1 PPM1B PRICKLE2 THBS1 NFATC4 PDGFA TBL1X PTPN11 ARHA KRAS SPDY1 SFRP1 ZFYVE16 RBL1 SMURF1 VANGL1 GYS1 TAOK3 SH2B3 PTPRE EP300 NFATC3 RRAS2 YWHAZ PMC7503332__F2 Schematic signaling pathway of TLR7 and 9 TLR9 IRAK1 IRF7 TLR7 IRAK4 MYD88 PMC11853781__F3 Luteolin multi-pathway treatment of IBD STAT3 IL10 KEAP1 PMC11853781__F4 Multi-pathway mechanisms of luteolin in inhibiting colorectal cancer NLRP3 KEAP1 EGFR PMC4174300__F4 Innate immunity to dengue virus infection and subversion of antiviral responses STAT2 UBR4 IRF9 TYK2 PMC4174300__F3 Innate immunity to dengue virus infection and subversion of antiviral responses MAVS TLR3 IRF3 TRAF3 TRAF6 PMC3510027__F3 Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease PIK3CA RAF1 MSLN PPP2R1B BCL2 RRAS PLK1 PIN1 PPP2R5D FNTA PMC3510027__F2 Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease GRIN2B LTBR APTX FABP1 BACE1 LHCGR IL18BP NR3C1 MKI67 NR2F6 NR3C2 RAB20 ADAM9 MED14 PPP2R1B CASP3 APP DIABLO HTT PMC3594740__F1 TLR signaling MAP3K7IP1 TIRAP TLR4 TAB3 MAL IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC8660693__F1 Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response CGAS IRF3 TNF PMC7023858__F3 IGFBP-3 was a predicted target of SAN by bioinformatics analysis LAT PMC5422801__F6 Hippo–YAP pathway mediates physiological resistance to gemcitabine LATS1 LATS2 CDA AMOTL2 PMC9317325__F3 Perivascular Mesenchymal Stem/Stromal Cells, an Immune Privileged Niche for Viruses? CD81 TBK1 MXRA8 MAVS RNASEL IRF3 IRF7 MYD88 TLR3 MSC TLR7 ISG15 JAK1 CXCR4 TYK2 PMC4040611__F5 An MAPK network downstream of SDF-1/CXCR4 signaling in breast CSCs HEL-S-31 SOS1 RPS6KA1 PAK4 MAPKAPK5 MAP3K11 MAP2K2 CXCR4 PTPN13 PMC8393567__F2 GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease MAP1B GSK3B WNT7A PMC2724989__F1 Macrophage activation by endogenous danger signals TBK1 TANK RNASEL TRAF3 TRAF6 TRAF2 FADD PMC9103623__F1 Prolonged Mechanical Ventilation: Outcomes and Management FOXO1 TLR4 MTOR PMC2910166__F7 drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans RAB10 EIF4H EIF4E PMC8889574__F1 Impact of High Dose Glucocorticoids on Bone Health and Fracture Risk in Systemic Vasculitides DKK1 IL6 CTLA4 RUNX2 MPO PMC11842380__F12 Signaling pathways that the exosome may regulate CD80 MAK PMC4572253__F1 Homocysteine metabolism HEL-S-61p PMC7813969__F1 Sex bias of females in survival from cancer and infections. Is X the answer? IFNG EZH2 PMC3843359__F2 MAPK signaling pathway is upregulated in OSI-906 resistant CRC lines RHEB TSC2 TSC1 INSR GRB2 PDK2 MTOR INS EIF4E PMC11813976__F2 Molecular mechanisms of STAT3 signaling pathway in CRC STAT3 EGF CSF1 PTPN9 NLK MTOR SRC TNF PMC4472073__F2 Mechanism of castrate-resistant prostate cancer.Notes: 1) Androgens bind and activate the AR despite the castration of testes-derived androgens RAN PMC9454891__F9 Apigetrin Promotes TNFAlpha-Induced Apoptosis, Necroptosis, G2/M Phase Cell Cycle Arrest, and ROS Generation through Inhibition of NFKB Pathway in Hep3B Liver Cancer Cells RIPK3 BAX MLKL RIPK1 PMC7243914__F5 Immune signaling responses occurring in chickens infected with Salmonella MAP3K7IP1 MAP2K4 TIRAP TLR4 NOD1 FZD1 TRAF6 MAP2K3 CARD9 CTNNB1 PMC7243914__F4 Immune signaling pathways in bovine monocytes IFNG STAT1 TLR9 IRAK1 SHE TRAF6 TYK2 IRAK4 MYD88 PMC7316088__F3 Hyperactivation of the ATR/CHK1/WEE1 pathway leads to acquired resistance to PARP inhibitors CDC2 ATR ATRIP WEE1 CLSPN PMC7316088__F2 ATR/CHK1/WEE1 pathway compensates for the replicative stress induced by gemcitabine CDC2 TOPBP1 ATR ATRIP WEE2 WEE1 CLSPN PMC5393594__F4 Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells STAG3 ZPBP HEL-S-278 EFHC1 SPINK2 ODF1 PMC11901387__F1 Effect of the microbiota on drug resistance in HCC STAT3 NLRP3 FOXO3A TLR4 EGFR AHR MTOR JAK1 PMC5214938__F1 Cross-regulation between interleukin-1 (IL-1) and type-1 interferon (IFN) inflammatory pathways as exemplified during Mtb infection IL1R2 TBK1 IL1R1 CGAS NLRP3 IL16 IFNAR1 CH25H AIM2 IRF3 PTGS2 PMC5835759__F1 Interactions among Protein Kinase C Alpha (PRKCA), NOS3, and BDKRB2 gene products within the ACE inhibitor pathway may affect the antihypertensive response to enalapril TIMP1 AGTR1 MMP2 BDKRB2 PMC8226943__F2 Redox and Anti-Inflammatory Properties from Hop Components in Beer-Related to Neuroprotection STAT1 CD80 NLRP3 COX1 KEAP1 COX2 NQO1 PMC9201217__F1 Toll-Like Receptors in Radiotherapy- and Chemotherapy-Induced Oral Mucositis: A Concise Review HMGB1 TNF MYD88 PMC2990976__F2 TNFA signaling pathways to NFKB activation MAP3K7IP1 TRADD TRAF2 PMC9028769__F6 Human Papillomavirus 16 E6 Suppresses Transporter Associated with Antigen-Processing Complex in Human Tongue Keratinocyte Cells by Activating Lymphotoxin Pathway TF LTBR TAP1 TAP2 PMC9201217__F2 Toll-Like Receptors in Radiotherapy- and Chemotherapy-Induced Oral Mucositis: A Concise Review CD40 CD80 HMGB1 TLR4 TLR9 TLR5 MYD88 PMC3942836__F1 Schematic review SHH SMO CXCR4 KRAS PMC5858164__F7 Working model of endothelial specific elevated miRNA302-367 attenuating embryonic hindbrain developmental angiogenesis by targeting CDC42 and CCND1 multiple pathways CDC42 CDK6 PAK1 GRB2 CCND1 CDK4 PMC8085478__F1 Sclerotic chronic GVHD: you may WANT to block WNT APC LRP6 CTNNB1 PMC7812258__F2 Mechanisms through which TLRs orchestrate pro‐tumour responses IFNE BCL2 PMC7812258__F1 Non‐canonical functions of TLRs TLR4 TLR9 TLR8 TLR7 ATG5 PMC9265395__F3 Diverse Functions of KDM5 in Cancer: Transcriptional Repressor or Activator? CDK6 KDM5A PTEN MYC PMC2637184__F1 New central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9 CXCL12 SMAD1 TGFA ITCH ECT2 CRKL ZYX ARHA FYN ERBB2 ChAT AJUBA LYN CXCR4 HCTP4 HDAC6 LCK PMC3660716__F1 Intracellular signaling pathways recruited by leptin STAT3 SOCS3 GRB2 MTOR PMC11165723__F3 Journey of a generation: advances and promises in the study of primordial germ cell migration CXCL12 KIF13B ROR2 KIT ARHA SRC CXCR4 LPP RAC1 PMC11650354__F2 Inhibition of the non-canonical Wnt signaling pathway by WIF1 ARHA DKK2 RAC1 WIF1 PMC8678483__F8 Different Molecular Weight Polysaccharides From Dendrobium officinale Kimura & Migo on Human Colorectal Cancer and Transcriptome Analysis of Differentially Expressed Genes HTRA2 BAX FADD PMC11650354__F1 Inhibition of the Wnt/Beta-catenin signaling pathway by WIF1 MMP7 DKK1 WIF1 PMC11650354__F4 DKK3-related signaling pathways in Wnt/Beta-catenin and non-canonical Wnt signaling DKK3 MYC CCND1 AXIN2 CTNNB1 PMC11650354__F3 Inhibition of the PI3K/Akt, NFKB, and TGFB signaling pathways by WIF1 SMAD2 MMP2 MMP9 MTOR WIF1 PMC11650354__F5 DKK3’s inhibition of the PI3K/Akt signaling pathway DKK3 PTEN RHO MTOR PMC5983834__F4 PI3K-AKT signaling pathway SYK EIF4B BAD RBL2 PTEN CD19 MTOR MYC RAC1 EIF4E RHEB TSC2 BCR RXRA MDM2 GRB2 CCND1 PMC7198545__F8 TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination TBK1 MAVS IRF3 TRAF3 TRAF3IP3 PMC2383925__F9 MiRNA model for the molecular pathogenesis of recurrent ovarian cancer EGF USF2 BRAF BCL2 MMP9 KRAS FGFR2 PMC8610166__F2 Targeting myeloid-derived suppressor cells for cancer therapy SEMA4D HDC CCR2 ARG1 IL8RB CCL2 PMC8590100__F3 Innate immune remodeling by short‐term intensive fasting TBK1 BAD RAF1 KIAA0226 TANK MTOR STX17 TRAF6 ATG3 ATG5 ULK2 HMGB1 SNAP29 UVRAG VMP1 CTSL DEPTOR ATG101 RHEB MLST8 ATG10 TSC2 ATG12 HEL-S-130P HEL-S-162eP WDR41 PMC7680678__F1 Therapeutic strategies have been developed to target various steps in the PI3K/AKT/mTOR pathway, thereby blocking cell proliferation, growth and survival EGFR PTEN MTOR PMC10216727__F3 Proposed mechanism of vagus-mediated liver regeneration STAT3 FOXM1 IL6 PMC6003401__F6 Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming TLR3 TIRAP TLR4 TRAF3 TRAF6 MYD88 PMC10216727__F2 Role and function of FOXM1 in pulmonary fibrosis STAT3 ACTA2 MMP2 CCNB1 PLK1 TNF CCND1 FGF2 PMC2768836__F1 Role of clathrin adaptor proteins in melanosome biogenesis TF KIF13A EEA1 PMC7460646__F2 Inflammation contributes to leptin resistance in the brain at the hypothalamic arcuate nucleus, and as a result, alters food intake and energy expenditure leading to obesity STAT3 MAP3K7IP1 REL PMC12112539__F1 IL-23 production and signaling pathway in the context of inflammatory bowel disease pathogenesis STAT3 IL1R1 JUN REG3G TIRAP TLR4 STAT4 TRAF6 IL23R TYK2 IRAK4 MYD88 PMC9294450__F3 Erectile Dysfunction: Key Role of Cavernous Smooth Muscle Cells PLCB1 PC ARHA PMC10216727__F6 EGFR/mTOR signaling pathways that regulate FOXM1 are involved in Beta-cell proliferation FOXM1 EGFR MTOR PMC3288293__F1 Molecular mechanism of senescence SIRT3 IL6 SIRT1 PMC12112539__F2 IL-23/IL-23R axis orchestrates innate and adaptive immune responses in the inflamed gut mucosa APC STAT4 IL23R TYK2 PMC4174300__F2 Innate immunity to dengue virus infection and subversion of antiviral responses MAVS TLR3 IRF3 TRAF3 TRAF6 PMC4449286__F5 Excess of rare, inherited truncating mutations in autism TNRC6B GRB10 GIGYF2 GIGYF1 RBM12 ZNF598 PMC2697172__F8 Sub-network associated with the Wnt signaling pathway SPEN SHF MYB CIC SIN3A TAF4 NUMB RHO SET TAF12 SF1 PSD SUFU TTK ESD PC SMO TBP PMC9386258__F1 Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism COX2 AIP MMP3 AHR IL6 VCAM1 CYP1B1 CYP1A1 IL1B PMC8236819__F2 Pathophysiologic Role of Neurotransmitters in Digestive Diseases DRD2 NLRP3 EGFR ADRB2 MMP2 MMP9 PMC8608597__F9 Super-enhancer-driven lncRNA-DAW promotes liver cancer cell proliferation through activation of Wnt/Beta-catenin pathway NR2A2 EZH2 PMC5896787__F2 Emerging concepts for immune checkpoint blockade-based combination therapies ZAP70 PC CPT1A LCK PMC8101994__F8 Proposed role of PD-L1 on contraction of activated effector T cells CD80 APC MTOR PMC4854959__F1 Androgen signal pathways SHBG SRY SRC PMC6343712__F6 miR-300 mediates the SP1/MMP9 pathway in BCa SP1 MMP9 PMC6678716__F2 CSCs-activated signaling pathways: Schematic representation of the signaling pathway responsible for induction and maintenance of CSC state LATS1 STAT3 LATS2 SUFU APC LRP5 LRP6 SMO IL6 CTNNB1 TGFBR1 PMC2837360__F1 Canonical Wnt/Beta-catenin pathway (modified after ()) DKK1 APC GSK3B RSPO1 PMC6784892__F4 Two intracellular and cell type-specific bacterial symbionts HEL-S-11 EYS PMC3637970__F1 Transforming growth factorB (TGFB) signaling pathway TF SMAD2 SMAD6 SMAD4 ID1 PMC9266365__F8 Metformin Attenuates UVA-Induced Skin Photoaging by Suppressing Mitophagy and the PI3K/AKT/mTOR Pathway PINK1 ATM MTOR PMC7690210__F1 Activation pathways of the complement system MASP1 C6 MASP2 HEL-S-62p C2 C9 C4A PMC7264474__F1 Ceramide and Sphingosine 1-Phosphate in Liver Diseases CERS3 SPP2 CERS5 SPHK2 CERS1 CERS2 SPHK1 HEL-S-5 CERS6 SPP1 PMC5428476__F10 Model depicting the involvement of autophagy-lysosomal system in apigenin-induced degradation of Beta-catenin during Wnt signaling GSK3B LRP5 LRP6 MTOR PMC10986035__F5 Pattern diagram for the role of NCAPD3 in NSCLC cell proliferation and apoptosis BAX IGF1 NCAPD3 CDK4 PMC11602425__F3 Metabolic reprogramming drives MASLD progression CXCL11 STAT3 PNPLA3 NLRP3 CXCL16 TERT MTOR PMC11602425__F2 Metabolic reprogramming drives HCC progression IKZF1 FH GLS HEL-S-133P SHD HK2 SIRT4 TIGAR MTOR HEL-S-51e MYC TXN PAX5 F2 PMC11602425__F1 Metabolic reprogramming of tumor cells HEL-S-133P HK2 PMC6747339__F1 Schematic representation of ERK1,2 signalling regulation of channels and transporters along the nephron RAF1 DCT PTH PMC3882431__F6 Schematic representation of the proposed pathway by which deficiency of FXR activates the STAT3 signaling pathway in the liver STAT3 IL16 SOCS3 PMC4254673__F8 Proposed model for autophagy and metastasis mediated by mTOR signaling BAX BAD PTEN MTOR PPY PMC7662528__F6 RGS Proteins as Critical Regulators of Motor Function and Their Implications in Parkinson’s Disease TLR4 RGS10 FADD PMC3940357__F1 Frizzled homolog proteins, microRNAs and Wnt Signaling in Cancer APC ROR2 LRP5 LRP6 RYK RHO NLK WIF1 CTNNB1 PMC11120667__F12 Proposed model of the mechanisms of action of female M BAX CASP9 FAS CASP8 EGFR CASP3 TRPV1 ATF4 FADD PMC11120667__F11 Proposed model of the mechanisms of action of male M BAX CASP9 FAS CASP8 EGFR CASP3 TRPV1 ATF4 FADD PMC12052780__F5 EVs in macrophage polarization within the ovarian tumor microenvironment STAT3 CD24 ADAMTS6 KLF6 HOXA10 SOCS3 SIRT1 KAT2B GATA3 PMC12052780__F4 Figure illustrates how various molecular factors drive TAM polarization and chemoresistance in the OC microenvironment POSTN ADM KLF6 FGF9 CPNE1 FPR2 ST3GAL3 ARHA IGF2BP2 GATA3 PMC3928842__F1 TLRs signaling pathway TLR1 TIRAP TLR3 TLR4 AK1 TLR9 TLR5 TLR7 TRAF6 MYD88 PMC3660182__F1 Glia-mediated detrimental and beneficial inflammatory pathways in PD FZD1 MPO PMC12052780__F1 Wnt and PI3K/AKT pathways involved in macrophage polarization and metastatic progression in the tumor microenvironment of ovarian cancer STAT1 CEACAM1 CCL3 ARG1 PTEN CD163 CTNNB1 PMC10484658__F2 Schematic diagram of ERS in renal resident cells in LN ATF4 VCAM1 XBP1 PMC3660182__F4 Crosstalk between inflammatory and Wnt/Beta-catenin signaling pathways in MPTP-induced SVZ plasticity EGF GSK3B WNT1 CTNNB1 PMC9299865__F1 Key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions NRK NAPRT NAMPT PMC4176007__F3 IL-6 synthesis and regulation of IL-6 mRNA stability by Arid5a ARID5A TLR4 MYD88 PMC7564205__F5 NRP1-ABCB8 pathway: Schematic representation of the NRP1-ABCB8 pathway in regulating iron homeostasis, iron-dependent oxidative stress, mitochondrial function and cellular senescence NRP1 FES VCAM1 ABCB8 PMC7729316__F1 Therapeutic approaches targeting tumor angiogenesis ENG DLL4 TMEM100 ID1 PMC5769625__F2 Layers of gene expression control in primed human PSCs CTCF PRDM14 IGF1 SMAD2 BMP4 APC SOX2 GRB2 CTNNB1 FGF2 PMC5583567__F3 Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis HRAS SHC1 MTOR DEPTOR PMC8645368__F2 Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation CXCL12 IDO1 CCL2 PMC1559676__F1 The unfolded protein response ELF2 ATF4 XBP1 PMC3164770__F5 FLCN pathway TSC2 BAD TSC1 PIR FNIP2 FLCN PTEN FNIP1 PMC9463442__F7 Regulation and role of RNAPII-generated nascent RNA to guide DNA end resection and DSB repair by HR RAD52 MRE11A BRCA1 DROSHA PMC9294638__F2 Emerging Role of Non-Coding RNAs in Senescence APC LRP5 LRP6 CCND1 CTNNB1 PMC11941683__F1 Summary of healing stages following a bone fracture SMAD1 DKFZp781O1323 APC SMAD6 MSC SMAD4 RUNX2 CTNNB1 PMC6823706__F3 Molecular mechanism of inflammatory adipokines involved in the pathogenesis of diabetic associated fatty liver disorders via suppression of insulin signaling resulting in insulin resistance FOXO1 PC MTOR IL1B PMC9294638__F4 Emerging Role of Non-Coding RNAs in Senescence CAB39 GSK3B PTEN MDM2 MTOR PMC8176847__F2 Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications BAX CASP3 FADD PMC8176847__F1 Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications HTRA2 BAX CASP9 CASP3 MDM2 PMC6823706__F2 Molecular mechanism of Fetuin-A involved in the pathogenesis of diabetic associated fatty liver disorders via suppression of insulin signaling resulting in insulin resistance TLR4 CD14 MYD88 PMC11847854__F3 Saikosaponin A-target-pathway network JUN EGFR GSK3B PTPN1 PTPN11 HIF1A IGF1R PTGS2 VEGFA CYP1B1 PLK1 RAC1 FGF2 BCL2L1 MMP2 IL2 CDK2 BCL2 FLT1 KDR PMC8487719__F1 Hedgehog signaling pathway SUFU PTCH1 DYRK1B SMO GLI3 PMC3493591__F5 Constitutive ß-Catenin Signaling by the Viral Chemokine Receptor US28 APC GSK3B ARHA CCND1 CTNNB1 PMC3712869__F4 Smooth Muscle Differentiation and Patterning in the Urinary Bladder FOXF1 BMP4 SHH SMO FOXL1 FOXI1 PMC3880284__F4 Human Mammospheres Secrete Hormone-Regulated Active Extracellular Vesicles HSP90AB1 ANXA2 HSD17B10 CD133 ALB MAEA IPP F8A3 MFGE8 HEL-S-162eP HEL110 ESPN ERMN BAK1 PMC6980436__F1 Heme metabolism and the microglial toll‐like receptor 4 (TLR4) signaling pathway following SAH: In the subarachnoid space, free heme is metabolized by heme oxygenase (HO)‐1, releasing iron (Fe2+), biliverdin, and carbon monoxide (CO) HMGB1 TLR4 TLR9 MYD88 PMC5355173__F2 Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells RHEB MLST8 TSC2 TSC1 PTEN GRB2 MTOR DEPTOR CCND1 AXIN2 IRS1 CTNNB1 PMC5355173__F3 Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells BAX APC CDK2 LRP6 PTEN CTNNB1 GLI3 PMC11693731__F7 Diagram of catalpol enhance Shh signaling pathway to promote neurogenesis and synaptogenesis by regulating mitochondria SHH SMO PMC5355173__F8 Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells CDH2 CDK6 WNT1 LRP6 WNT3 AXIN2 SIRT1 CTNNB1 PMC14940__F10 A signaling pathway of c-Met for cell scattering HGF VAV2 RHO PMC4851234__F2 Negative regulators of necroptosis RIPK3 TRADD MLKL RIPK1 PPM1B TNF TRAF2 PMC3975104__F2 A simplified model of some of the signaling pathways leading to LTD of the pf-PC synapse IGF1 GC PC IGF1R PMC7793877__F5 Integrative Analysis Reveals Common and Unique Roles of Tetraspanins in Fibrosis and Emphysema AURKA JUND GULP1 FAS TGFB1 PCNA SMAD2 SMAD4 HIF1A MAP2 STK32C RB1 CSNK1E CLU CRY2 FGFR4 AHR CDK4 LPL NPAS2 HEL-S-101 PER2 JUNB CSNK1D PER1 CRY1 BAG4 TNF KRAS FOS BEX1 ATF3 UHRF2 THRSP RELA PPP2R1B DDIT3 CDK2 MAPK10 REL LCK PMC4196646__F1 Signalling pathways connected to autophagy GSK3B MTOR DISC1 CTNNB1 PMC5796046__F3 PB1-F2 virulence BAX TBK1 MAVS NLRP3 IRF3 IRF7 TRAF3 TRAF6 CALCOCO2 TRAF2 IL1B PMC5265918__F9 Atorvastatin inhibits insulin synthesis by inhibiting the Ras complex (Ras/Raf/extracellular signal-regulated kinase/CREB) in INS-1 cells GRB2 PDK2 PMC7374820__F5 Ingenuity Pathway Analysis (IPA) of network of eight DE genes KRT18 PPIC DYRK2 NPEPPS TAF4 PRKAG2 DUT PMM1 ACOT11 PIGF CTPS1 FOXC2 MOS UGDH APH1B TINAGL1 MMP3 FAT1 TSPYL2 WNT9A STC1 CP PMC5511151__F7 Mechanisms underlying crosstalk between Wnt/Beta-catenin signaling and insulin signaling via Irs1 during hepatocarcinogenesis IRS1 PMC11278952__F3 Alterations of bile acids involved in the synthesis pathway in HD CYP8B1 CYP7A1 GCA CYP46A1 CYP7B1 CYP27A1 PMC5967641__F1 NAD+ biosynthesis, consumption and salvage pathways NNMT NRK NMNAT1 NAMPT NMNAT2 NMNAT3 PMC5471278__F5 Regulatory network model of DNA replication coupled with nicotinamide DBF4 MCM3 MCM2 SIRT1 PMC5471278__F3 Interaction network model RAD18 TXNDC12 LTBR TYMS NDUFA13 NDUFS3 ERN1 TRIP12 TMX4 CDK6 PRKCA PAH POLE SRC TOPBP1 TRIO RAD51 OPA1 RBMS1 DTL PLAUR APC RIF1 PRIM1 POLA2 BRCA1 PARL ARHGEF4 USP22 BCL2 MCM6 DIABLO RASSF1 TNFRSF1A BRCA2 HEL-S-269 CLSPN CHTF18 HEL-S-310 BLM RBBP7 FOXM1 ERF DIDO1 CLU MBTPS2 CCNB1 TOP2A DBF4 OS9 EIF4B ECT2 RRM1 RRM2 NPAT RPA1 PAWR HYOU1 CHEK1 NFE2L2 WFS1 DNAJC10 PMC9173662__F1 Complement pathways CRP CPB2 HEL-S-62p C1S CFHR1 C1R CFH CPN1 VTN CD46 CD55 C4A C2 CLU CPN2 C4B_2 PMC10688769__F4 miRNA alterations affect cartilage synthesis SOX9 MSC ADAMTS5 COL2A1 PMC8932121__F2 Inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD CSA2 NLRP3 TRAF6 MYD88 PMC6073096__F4 Simplified DNA repair pathway diagram ATR RAD51 BRCA1 BRCA2 ATM SSB PMC10688769__F2 Cell-produced SASP affects OA DNMT3B ADAMTS4 SOX9 MSC ADAMTS5 COL2A1 PMC7263368__F1 Representation of Hippo-Yap core kinase signaling cascade LATS1 LATS2 STK4 PITX2 PMC6754407__F7 Model of SHH induced increase of HELLS HELLS SHH YAP1 PMC7263368__F5 Representation of Yap regulation by P2y2 signaling LATS1 LATS2 PMC10995332__F5 Underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma TF CDH2 RCL1 HEL113 SMYD3 ZEB2 GATA6 CTNNB1 PMC10995332__F4 MiRNAs affect the occurrence and development of EMT in liver cancer cells by activating the TGFB signaling pathway and cross-talking multiple signaling pathways including PI3 K and MAPK CDH2 DNMT3B SMAD9 SMAD1 HEL113 DKFZp781O1323 SP1 SMAD2 SMAD6 SMAD4 MMP9 FAP MMP2 PMC6540604__F1 The deregulated metabolic pathways in AML TET2 BAX ASS1 FAS HEL-S-133P CD36 MCL1 SPHK1 FABP4 CS PMC8932121__F4 Inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD TBK1 CGAS IRF3 TNF OPTN C9orf72 PMC6888166__F1 Signal transduction of the unfolded protein response (UPR) ATF4 EIF2A XBP1 PMC5340842__F1 P. infestans infection cycle and the many roles effectors play in modulating plant cellular processes TF MAP3K2 MAP3K1 MAP2K1 MAP2K2 BAK1 MAP2K3 PMC6804972__F3 Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance NR1i1 KCNJ5 HEY2 ATP2A2 FOXM1 ALDH2 MYL3 CASQ2 THBS4 CTGF KCNJ2 NPPB RCAN1 ACE2 BCL6 NPRC PMC10995332__F3 Underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma CDH2 CXCL12 HEL-S-28 PTEN HIF1A MTOR PMC10995332__F2 Underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma NKD1 CD44 WNT3A APC FZD7 WNT1 NLK MYC LEF1 RAC1 CTNNB1 PMC6901970__F1 Regulation of Tfr cell differentiation and function STAT3 ICOS IL10 FOXO1 PTEN FOXP3 PMC1728094__F1 The receptor for IL-6 consists of the ligand binding component (IL-6R) and the signal-transducing gp130 STAT3 VCAM1 PMC11203016__F10 Illustration of the Toll-like receptor signaling and apoptosis pathways in M POR CAD TIRAP STAC CD14 ATM CP PMC7225374__F11 Core apoptotic pathway and its regulation by miRNAs in THP-1 cells exposed to the lower dose of CdS QDs CDC42 BAX BAD FAS FAF1 PTEN BMF HRK SIRT1 BIK FADD PMC7940541__F7 Schematic model: the mechanisms through which huaier extract inhibits the growth of prostate cancer TMPRSS2 USP14 SMYD3 KLK3 PMC8542577__F4 Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease PROX1 NOP16 NCOR1 FOSL1 PROK2 RUNX1T1 THBD COL3A1 NR5A2 CEBPB TEF PMC8548714__F1 Current Application and Future Prospects of Astragalus Polysaccharide Combined With Cancer Immunotherapy: A Review IFNG STAT3 STAT1 ROS1 CCL22 TGFBI ALK MSC PMC8542577__F3 Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease VWF SERPINF2 KLKB1 SERPINA1 PLG F11 TFPI F10 F3 THBD A2M BOK F8 F9 PMC8546664__AF1 Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy IFNG IFNE TBK1 ATM IRF3 PMC4906842__F2 Steroid biosynthesis pathway CYP17A1 CYP11B2 CYP11A1 STS PMC11972380__F8 Schematic diagram deciphering the mechanisms by which ROBO1, G3BP2 and eIF3A form hetero-complex to mediate radio-resistance in ESCC cells G3BP2 EIF3A MTOR ROBO1 PMC2996094__F11 Proposed model of GF-mediated regulation of IGFBP-3 EGF EGFR MTOR PMC8005042__F7 Pyrimidine biosynthesis in the pyrimidine metabolism pathway CAD UMPS DHODH PMC11628519__F3 Molecular mechanisms of the JAK-STAT pathway in CRC cell proliferation, apoptosis, migration, and invasion NR1i1 STAT3 BRD4 ATM ARHA MYC PMC8415165__F11 Extract of Sonneratia apetala Leaves and Branches Ameliorates Hyperuricemia in Mice by Regulating Renal Uric Acid Transporters and Suppressing the Activation of the JAK/STAT Signaling Pathway STAT3 SOCS3 IL1B PMC8267717__F2 Intestinal Permeability Is a Mechanical Rheostat in the Pathogenesis of Liver Cirrhosis TLR4 CD14 IRAK1 IRF3 TRAF6 LBP IRAK4 MYD88 PMC8945898__F1 Histamine Intolerance—A Kind of Pseudoallergic Reaction HDC DAO PMC4427128__F1 Coagulation and inflammatory response activation during dengue TF CD40 TFPI IL16 CCL2 PMC4477307__F10 Cooperative disruption of signaling network downstream of mutated KRAS CRK BAD TIAM1 SOS1 PAK1 KRAS RAC1 PMC2647860__F7 p53, Cyclin-dependent Kinase and Abnormal Amplification of Centrosomes PLK1 CDC25B PMC9086356__F1 Innate Lymphoid Cells in Cancer Development and Immunotherapy ID2 CCR6 AHR TOX NFIL3 GATA3 PMC7265313__F9 Final scheme CEP164 FBF1 SCLT1 DAP SMO PMC5817860__F3 Crosstalk between c-Met and EGFR EGF BAD TGFA EGFR GRB2 MTOR PMC10537261__F3 Ghrelin as a Biomarker of “Immunometabolic Depression” and Its Connection with Dysbiosis NPY ARC AgRP PMC3421049__F1 Genomic Variation and Neurohormonal Intervention in Heart Failure GNB3 CYP11B2 PMC7987467__F1 Severe SARS-CoV-2 syndrome as a result of hypoxia and HIF-1 signaling pathway activation HEL-S-62p CCL2 TNF PMC7403780__F6 Recombination salvage pathway regulation RAD52 RAD51 PCNA PMC2929667__F6 Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation ONECUT1 IGF1 STAT5B FOXO1 IGFBP1 IGFALS PPARGC1A FOXA2 GCK PCK1 GHR IRS1 PMC8946206__F2 Angiogenesis Inhibitors and Immunomodulation in Renal Cell Cancers: The Past, Present, and Future EGF EGFR MTOR PMC544835__F1 Reverse Cholesterol Transport LDLR APOB ABCA1 PMC6406579__F3 Current model of Cln3 function in Dictyostelium HEL-S-130P CLN3 TPP1 PMC4403904__F1 Signaling pathway mediates hepatic fibrogenesis: (A) the TGFB1/SMAD signaling pathway, and (B) TLR4 activated-MyD88/TGFB1/NFKB pathway SMAD2 SMAD4 TRAF6 MYD88 PMC3681501__F5 Lin28b Promotes Head and Neck Cancer Progression via Modulation of the Insulin-Like Growth Factor Survival Pathway HMGA2 CCND2 IGF1R IGF2BP2 IGF2 PMC5113843__F3 Proposed metabolic role of RubisCO, with genes identified in the PER-1 (blue line) and WS6-1 genomes (purple line) HEL107 RPE HEL-S-304 RPIA HEL-S-162eP PMC7136022__F4 PGE2 signaling pathways COX2 GSK3B SRC PMC6650088__F2 Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference MPL PIK3CA KCNK2 RUNX1 CHIT1 PI3 RGS5 PIK3R1 MMP3 PTEN OR10X1 SET PMC3726373__F5 Ribonucleotide Reductase Large Subunit M1 Predicts Poor Survival Due to Modulation of Proliferative and Invasive Ability of Gastric Cancer CDH2 RRM1 PTEN PMC6958506__F4 A summary of miR-205-5p expression regulation and direct targets of miR-205-5p and their biological effects ERBB3 AMOT ERBB2 NOTCH2 LAMC1 HES1 YAP1 FGF2 PMC8637616__F1 Neuroprotection by dipeptidyl-peptidase-4 inhibitors and glucagon-like peptide-1 analogs via the modulation of AKT-signaling pathway in Alzheimer’s disease PTEN MTOR CTNNB1 PMC6164844__F2 Suggested mechanistic pathway of different flavonoids in the activation of non-shivering thermogenesis in BAT and WAT PRDM16 UCP1 CPT1A SIRT1 PMC4595741__F3 Revisiting the chlorophyll biosynthesis pathway using genome scale metabolic model of Oryza sativa japonica MAL CIT PMC4595741__F1 Revisiting the chlorophyll biosynthesis pathway using genome scale metabolic model of Oryza sativa japonica MAL HP CIT PMC4795655__F4 De Novo Transcriptome Analysis Provides Insights into Immune Related Genes and the RIG-I-Like Receptor Signaling Pathway in the Freshwater Planarian (Dugesia japonica) TBK1 RIGI IRF3 IRF7 TRAF3 TRAF6 TRAF2 PMC9575458__F2 Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview INSR PTEN IRS1 PMC4808588__F4 Multifaceted biology of plasmacytoid dendritic cells SCARB2 UNC93B1 BTK PLSCR1 TLR9 IRF7 PACSIN1 DOCK2 SLC15A4 MYD88 PMC7243120__F1 An autoregulatory loop controls Proline biosynthesis ALDH18A1 ATF4 EIF2A PMC4338588__F1 Hypothetical model illustrating the molecular basis of insulin-induced metabolic stress in patients with poorly controlled T2D in which both blood glucose and FFA levels are persistently elevated TG CD36 DYSF PMC3186011__F1 Cell surface and endosomal recognition of viruses by Toll-like receptors (TLRs) TLR3 TLR4 TLR9 IRF3 TLR7 IL1A IL6 TRAF3 TRAF6 IL1B PMC9594080__F1 Redox potential determines NSPCs fate LOX KEAP1 PRX ATM MTOR PMC1482699__F5 GenMAPP growth hormone (Gh) signaling pathway NMI SP1 SOCS4 AK3 GHRH SOCS2 PTPRT GHRL FURIN GHRHR DAO CRK DUSP19 CEBPA GRB10 FYN STAT5B SSTR2 CEBPD SP3 CALM1 STAT4 CEBPB GHR PMC5454413__F2 Proposed regulatory signaling network for HCV entry HRAS BMPR2 BMP6 EGF ICAM3 VLDLR EGFR SMAD6 LDLR BMP7 ARHA PMC6124548__F6 Somitogenesis and somite patterning BMP4 SHH BMP7 FGF8 FGF2 PMC12112207__F5 Isochlorogenic Acid C Alleviates Allergic Asthma via Interactions Between Its Bioactive Form and the Gut Microbiome CGA ALOX5 ALOX15 ALOX12 PMC4457157__F3 Crosstalk between growth factor and adhesion protein signaling GSK3B SRC CTNNB1 PMC3651056__F2 Arachidonic acid metabolic pathways and the role of IL-13 LTB LTA COX1 IL13RA1 PMC3308858__F8 How GSK3B phosphorylation is involved with microtubule destabilization CDK5 CRMP1 GSK3B PMC7207169__F3 MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? MYC XBP1 ERN1 PMC7207169__F2 MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? ATF4 EIF2A PMC4094593__F9 Diagram of the roles of miR-206 in hepatocellular carcinoma (HCC) HepG2 cells BAX NOTCH3 HES1 PMC8815128__F6 N6-methyladenosine-dependent modification of circGARS acts as a new player that promotes SLE progression through the NFKB/A20 axis AGO2 YTHDF2 POLI PMC3638721__F7 TRAIL-activated proapoptotic and antiapoptotic pathways CASP3 FADD PMC6735542__F1 SLC3A2 in regulation of autophagy activation and cell radiosensitivity SLC3A2 COCH SLC7A11 SLC7A5 MTOR PMC3745713__F2 Methionine–homocysteine and aromatase pathways and their involvement in 2-ME synthesis VIT MTRR MTR PMC9022112__F1 Nitric Oxide in Plant Senescence HEL60 HEL-S-162eP PMC8286120__F4 Goblet Cells in Intestinal Barrier and Mucosal Immunity HEL-S-92n IL25 MUC2 IL33 PMC8267409__F1 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects SLC3A2 ABCC1 KEAP1 PIK3R3 GSKIP USP22 MAGEA3 PTEN PSEN1 SIRT1 PMC9450509__F9 DDX56 inhibits PRV replication through regulation of IFNB signaling pathway by targeting cGAS TBK1 CGAS IRF3 DDX56 PMC8267409__F3 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects HMGA2 AGO2 DHFR BCL2 ZEB2 PAX6 SND1 PMC8333094__F9 Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic Beta-oxidation ECHS1 CROT PMC8267409__F2 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects RBM38 STAT3 ATG3 COX2 OGFR USP22 PTEN ZEB2 MTOR SIRT1 PMC4629213__F1 Bile acid synthesis and metabolism CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC8267409__F4 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects EPCAM STAT3 EZH2 PTEN HEL-S-4 MDM2 MTOR PMC3285581__F7 Msx Homeobox Genes Critically Regulate Embryo Implantation by Controlling Paracrine Signaling between Uterine Stroma and Epithelium MSX1 MUC1 HEL110 MSX2 CTNNB1 PMC5739690__F8 Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway IRF9 USP18 JAK1 TYK2 PMC7432461__F3 Interactions of coronavirus proteins with metabolic pathways ACSL3 ALG11 ATP6V1A DCTPP1 NDUFA13 THTPA NDUFA10 ACADM SPTLC2 FPGS AASS CYP51A1 GPAA1 ACSL5 PRIM2 IMPDH2 NANS PRIM1 ALDH3A2 ALG5 GCS1 POLA1 ENO3 CHPF2 POLR2B POLA2 PPT1 ADK ENO1 PIGS HSD17B4 MTMR3 ATP6V1G1 NDUFB9 GANAB HEL20 PIGO DHRS9 FAHD1 PLD3 AGPS RRM2 PCYT2 LPIN3 CHPF ALG8 GNE XDH STT3B ADA PMC11817190__F3 Influence of micronutrients on bone metabolism SOST DKK1 MSC PTH RUNX2 PMC5753398__F1 Hedgehog signaling pathway HHIP DHH SHH IHH SMO GLI3 PMC2613930__F4 Genes that contain the 100 most differentially methylated CpG sites between normal and lung cancer tissue samples (p-value < 0.005) TP73 MYOD1 SFTPA1 CD2 PENK MAGEA1 HOXA11 TERT HTR2A NEFL TNF PTPN6 IGF2 WT1 GALR1 MOS POMC CFTR NPY NCL PMC7662392__F2 Potential mechanisms for KSHV manipulating IL-1 signaling pathway IL1R1 IL18R1 IL1RL1 IL33 IRAK1 IL36A IRAK2 IL36B IL18RAP IRAK4 MYD88 PMC9599057__F3 Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer CDC2 BAX CDK6 CDK2 PTEN MDM2 TNF CDK4 FADD PMC5943638__F1 Metformin as a Tool to Target Aging IGF1 INSR MTOR SIRT1 IRS1 PMC11743488__F1 TGFB pathway signaling in MFS LTB TGFBR1 PMC9319879__F2 Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications BAD TIAM1 RASSF1 GIP KRAS PMC5648141__F10 Inferring gene and protein interactions using PubMed citations and consensus Bayesian networks RYR2 GFAP IRF9 MCL1 MTOR PMC5580487__F2 Pro-apoptotic role of HBV BAX FAS APAF1 FADD PMC9319879__F1 Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications TIAM1 GIP GRB2 MTOR KRAS PMC10985007__F1 HIFs and NRF2, adaptive response systems to variable oxygen availability RBX1 VHL PMC5580487__F1 Inhibition of apoptosis by hepatitis B Virus (HBV) infection CD40 JUN BAD TRADD DBH RELB PTEN SRC REL APAF1 TRAF2 FADD PMC3510514__F6 Model for the role of Spartan in DNA damage tolerance RAD18 PCNA USP1 PMC8718907__F2 Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology NEU2 NANP NEU4 GNE NEU3 NEU1 CMAS SLC17A5 NANS SLC35A1 PMC4303658__F1 Thymidine metabolism in the cytosol and mitochondrial matrix CDA DHFR TYMS PMC5302999__F2 Progress and perspective of TBX6 gene in congenital vertebral malformations MESP2 WNT3A TBX6 HES7 PMC6733361__F1 The potential molecular pathways representing potential targets for treatment in patients with ACC, based on the results presented in the current review IGF2R CDKN2A TSC2 CDK6 TSC1 PTEN IGF1R IGF2 IRS1 CDK4 PMC3653416__F2 Autophagy in alcohol-induced liver diseases CYP2E1 ULK1 MTOR PMC6651518__F10 Mutual interactions of expression of the genes examined with qPCR and shown in , and CAV2 TIMP1 LAMA1 HEL70 VEGFA IL6 CXCL8 HEL114 TUBB1 TLN1 LAMA3 RDX PS1TP5BP1 PMC9388619__F2 Canonical G1/S pathway RB1 WAS PMC6353800__F1 Schematic overview of major enzymes and metabolites involved in the regulation of gluconeogenesis TG PC PMC2515553__F1 Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective TES CAV3 STAT3 STAT1 LOX GSK3B PTEN MDM2 JAK1 SRC LCK PMC5055986__F7 A probable signaling pathway of folic acid mediated modulation of inflammatory response in microglia cells SOCS1 IL16 SOCS3 PMC7867260__F3 Gluconeogenesis and other rescue pathways for the generation of metabolic intermediates in low-glucose conditions PCK2 FBP1 PCK1 PMC4252877__F4 Embryonic development, organ development, organ morphology, cellular growth and proliferation, cancer, and tumor morphology KRT18 EMID1 FOXA1 AGPS MEOX1 NDUFV3 DGIC NTRK2 AREG IGF2 STK39 RUTBC3 CD200 CCND1 PMC6353800__F4 Hepatic gluconeogenesis is modulated by histone deacetylases (HDACs) HDAC3 NR2A1 FOXO1 CRTC2 GCGR RORA HDAC6 PMC7867260__F2 Biosynthetic pathways branching from glycolysis in glucose-replete conditions GLS HEL-S-133P HK2 PMC11662784__F5 DEAD-Box Helicases in Colorectal Cancer: DDX27: DDX27 promotes the gene expression of known CSC markers (CD44, CD133, EpCAM, LGR5), stabilizing the self-renewal phenotype of CRC cells and contributing to tumor initiation and development CD44 EPCAM CDK6 SMAD2 DDX27 FUT3 WEE1 DDX46 GPR49 CCND1 DDX56 STUB1 PMC11662784__F4 DEAD-Box Helicases in Colorectal Cancer: DDX3: DDX3 enhances the transcription of KRAS by increasing the binding of SP1 to the KRAS promoter, leading to increased KRAS expression and activation of the PI3K/AKT pathway CDC2 DDX5 RPL35 SP1 DDX10 DVL2 MTOR KRAS CYBRD1 WDR5 CTNNB1 FOXM1 DDX27 NPM1 PMC11662784__F3 DEAD-Box Helicases in Gastric Cancer: DDX5: DDX5 increases the expression of p-mTOR and p-S6K1, promoting the growth of gastric cancer DDX5 DDX24 CCNE1 FOXO1 DDX27 GSK3B CDK2 PTEN MTOR DDX46 DROSHA LPP PMC11662784__F2 DEAD-Box Helicases in Esophageal Cancer: DDX5: DDX5 enhances the expression of CDK2 and Cyclin D1, promoting the G1/S phase transition in esophageal cancer cells DDX51 DDX5 CDK2 PTEN MTOR DDX46 CTNNB1 PMC6405391__F1 Energy imbalance leads to obesity TG IL6 TNF PMC3941025__F1 MAVS filaments and activation of the IFN-I pathway MAVS IRF3 IRF7 PMC5510910__F9 Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum SYK NLRP3 IL1B PMC4014927__F2 Summary of statin‐mediated peroxisome proliferator‐activated receptor G (PPARG) activation in macrophages CDC42 RHO ABCA1 PMC12230643__F4 Multi‐omics network of hyperglycemia‐induced vascular calcification GOT2 GAD1 pcap GAD2 AGTRAP TNIK PMC10341911__F3 Syntenic analysis of genes in the Moso bamboo and rice cytokinin pathway families HP PMC5448611__F9 PPI network of new predicted LUAD-related genes KLF4 RCC1 JUND ADAMTSL3 CD36 PGR THBS2 ACTN2 TCF4 TYMS TUBB6 PRKCH TGFBR2 JAM2 SLIT3 SLIT2 CSTF2 CENPL BMPR2 PRICKLE2 TIMP3 JDP2 STARD13 ARAP2 FGF2 SPN MKI67 FLI1 PAPSS2 TNS3 FZD4 STX11 IL8RB ARHGAP24 CP PMC5933117__F6 Model of rRNA biogenesis in rice HEL-S-66p C2 POLI PMC4700483__F5 MYC splicing connections in cancer MAX PTBP1 MDM2 MYC CCND1 PMC4467525__F5 Summary of altered glucose metabolism in MCF10A-ras cells HEL-S-133P HEL-S-68p PMC7183504__F2 Key interactions of BMX and its pathways TEC STAT3 STAT1 BTK PKD1 PIM1 PAK1 TXK ITK BMX ARHA TNF PMC4052589__F1 Possible mechanisms of the opioid receptor–mediated influence of morphine on tumor growth EGF BAD MOS ARHA SRC CCND1 PMC4515825__F9 Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis HEL-S-32 MDH2 HEL-S-1a PMC5039670__F3 Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research THBS1 DKFZp781O1323 SP1 SMAD2 SMAD6 SMAD4 NODAL ARHA PITX2 BAMBI IFNG RBX1 SMURF1 E2F4 FST ROCK1 SKP1 SMURF2 PMC9612132__F2 Heparin and Heparin-Based Drug Delivery Systems: Pleiotropic Molecular Effects at Multiple Drug Resistance of Osteosarcoma and Immune Cells STAT3 ABCC10 ABCC1 HIF1A ABCG2 SRC NOTCH1 ABCB1 IRS1 CTNNB1 PMC9302595__F2 Extracellular signals activate the intracellular signaling pathway mTOR TSC2 TSC1 PTN ID2 PTPA LGI1 FGFR2 PMC6000924__F2 Summary of the putative mechanisms of mutations in the LRRK2 ROCO domain VPS35 OPA1 MFN1 MFN2 PMC4923873__F1 Plasma proteomic analysis of stable coronary artery disease indicates impairment of reverse cholesterol pathway CAD SCX SET PMC7598260__F7 Visual representation generated by MetScape (CREGN) application of the Urea cycle and metabolism of arginine, proline, glutamate, aspartate and asparagine, a common pathway among the three species ASL SMS GPX4 ARG1 GPX3 ASPA GPX6 NAGS SRM ACY3 GPX7 ASNS CSTA ARG2 DHPS HEL-75 PMC4852766__F6 Proposed models that potentially link collagen VI myopathy and circadian genes FOXO3A ATG14 HIF1A MTOR PMC5039670__F4 Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research RFWD2 BAX CASP9 ATR FAS SIAH1 CASP8 PERP PTEN MTOR MYC TSC2 CDK6 CASP3 CDK2 ATM PIGS MDM2 CDK4 PMC9302595__F1 ET-1 signaling in OPCs GSX1 EGFR EDNRB UST S100B PMC4538650__F2 Schematic of TRIM21 antiviral mechanism HEL-S-71 TBK1 UBE2V2 RIGI UBE2W IRF3 TRIM21 PMC5713369__F5 Proposed mechanism whereby SM70EE ameliorates learning and memory impairments in mice with an intracerebroventricular injection of amyloidB 1–42 (AB1–42) BACE1 APP BDNF PMC10137601__F7 Working model illustrating the mechanism that underlies the role of RA in regulating LH-induced oocyte meiotic resumption NPPC ZFP36 EREG EGR1 EGFR PDE3A RBP4 NPR2 CNP AREG PMC8120225__F3 MicroRNAs in the osteogenic and chondrogenic differentiation of mesenchymal stem cells and bone pathologies SMAD1 MAP3K7IP1 DKFZp781O1323 SMAD2 SMAD4 SMURF2 DLX5 PMC3697968__F5 Model of DAF-2/IGFR pathway regulation by DPY-21 PMC6651415__F5 Possible mode of cell death pathway in Caco-2 cells FAS BCL2L2 RIPK2 BCL2L10 CD27 TNF BIK PMC7462863__F6 Genomic landscape of Mongolian hepatocellular carcinoma MAX VPS13A PIK3CA PTEN FKBP9 AMER1 MYC CTNNB1 FGFR2 SPTA1 MGA ALB RB1 MDM4 SMC6 CCNE1 tmp_locus_29 AK2 MLX ATM RPTOR PCLO ERBB4 PCDH7 APC TLE4 KIT SFRP1 CSMD2 TSC2 CSMD3 PNRC2 PDGFRA APOB GTF2IRD2B PMC7114592__F2 Role of MNK1 in viral mRNA translation BPI GRB2 PMC4843955__F1 Signalling and muscle proteins synthesis (MPS) responses induced by amino acids (AAs) and different contraction intensities EEF2 MTOR EIF4E PMC2474943__F7 Points of action of flavonoids within PI3K/Akt signalling pathway BAD PDK2 MTOR PMC6291580__F1 Genetic determinants of cardiovascular risk in SLE IFNG IL19 FAM177A1 STAT4 IRF8 HLA-A PMC2474943__F5 Points of action of flavonoids within p38 pathway MAX MAP3K7IP1 ATF2 PMC2474943__F4 Points of action of flavonoids within JNK pathway HSF1 SMAD4 ATF2 PMC7031694__F2 Ionic versus signaling pathways for cardiotonic steroid effects EGF EGFR SRC PMC3351101__F2 Regulation of cytoplasmic mRNA decay CTIF EIF4B ELF2 PABPN1 PABPC1 ELF3 MAGOH EIF4E PMC9411277__F4 Targeting of the tumor immune microenvironment by metformin HEL-S-92n CD80 IGF1 PMC8109080__F9 Mechanistic schematic diagram showing Compound 3C alleviates atherosclerosis by multiple mechanisms TG STAT1 APOE PMC4399077__F5 Canonical and noncanonical Sap-induced inflammasome activation NLRP3 IFNAR1 IL1B PMC8379419__F2 Arginine metabolism and its functions in growth, nutrient utilization, and immunonutrition of fish IGF1 ARG1 INS ARG2 SLC38A9 PMC5925453__F7 Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-Small Cell Lung Cancer Associated With Poor Prognosis STAT3 EGF HGF EPHA2 PXN EGFR AREG MTOR VGLL4 YAP1 CDCP1 LATS1 ERBB3 LATS2 ERBB2 LYN SRC PMC7377265__F7 Proposed Model Illustrating the Role of GABA and GABAB1R in PTGs CASR PTH PMC6525564__F4 Adrenal C19 steroid pathway HSD3B2 STAR CYP17A1 CYP11A1 HSD11B2 PMC4541793__F1 ANTI-TGF-ß THERAPY IN FIBROSIS: RECENT PROGRESS AND IMPLICATIONS FOR SYSTEMIC SCLEROSIS SMAD2 UNK PMC9378677__F8 Schematic view of cell death signaling induced by 5’-ppp-RNA, cytosolic dsRNA, and extracellular dsRNA CASP9 CASP8 TLR3 IRF3 FADD PMC9024684__F2 Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease FYN PTN IL34 CTNNB1 PMC5748797__F1 Formation of resveratrol metabolites by various UDP-glucuronosyltransferases (UGTs) and cytosolic sulfotransferases (SULTs) in humans UGT1A1 ST1A5 UGT1A9 SULT1A1 SULT1A2 SULT1E1 PMC6874786__F1 PI3K/AKT/mTOR pathway in AML STAT3 BAX ATG12 PTEN IL6 ATG5 PMC7647985__F4 ERK5 regulates the FAK signaling DOCK3 VTN VEGFA RHO ITGB3 RAC1 FGF2 CRK ITGB1 NFKBIA GRB2 WASF2 ITGB5 PMC6592856__F3 Hippo signalling pathway: key components and regulatory mechanisms MOB2 ARHA NF2 PMC7738833__F8 Hypothetical model illustrating that ALKAL1 plays an important role in colorectal cancer migration and invasion via activating SHH signaling pathway ALKAL1 SUFU LIMK1 ROCK1 PTCH1 SHH MMP3 SMO MMP9 PMC3765338__F3 Altered CREB/E2F1 signalling networks in co-treated HMCs RGS2 PPARG CXCL12 FOXE1 E2F7 ABCA1 RB1 EPHB2 TFRC CEBPD BMP4 LDLR FHL1 CTGF MAP2K3 CREB1 TOP2A MYBL1 CDH2 CDC2 ETS2 ADM JUNB SCD LEPR IFI16 FABP4 CBX3 ID1 FGF2 ID3 ACAN PDGFRA EDN1 EN1 IGFBP7 EGR2 CPT1A HMGB2 KAT2B PMC5908807__F2 YAP is at the epicenter of a signaling network AURKA EGF TGFA MSLN EDN2 CXCL5 EGFR IGFBP2 KIF23 FOXM1 EZR CDK6 DKK1 ITGA2 GPR87 MUC1 AHNAK CCND1 SERP1 RRM2 AREG NOTCH2 KRAS HBEGF FOSL1 CEP55 AJUBA PMC11680093__F5 Induced Pluripotent Stem Cells in Birds: Opportunities and Challenges for Science and Agriculture PGC SMAD1 DKFZp781O1323 SMAD2 BMP4 SMAD4 PMC7831924__F2 Modulations of Hippo signaling in gliomas LATS1 LATS2 NEDD4 CUL7 EGFR IKBKE GSK3B AMOTL2 HDAC9 GSC MTOR CTNNB1 PMC9426031__F7 Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive niche TH ELL MSC SOX21 PMC5908807__F1 Hippo signaling and YAP phosphorylation and translocation LATS1 LATS2 MAP4 PMC4166351__F1 AB production and removal from the brain IDE HEL111 APP PMC7831924__F1 Canonical Hippo signaling pathway in mammals LATS1 BIRC5 LATS2 AXL TEAD2 TEAD3 SHH MYC TEAD4 PMC5908807__F4 YAP signaling is associated with unfavorable prognosis for PDAC AURKA TGFA MSLN EDN2 CXCL5 EGFR IGFBP2 KIF23 FOXM1 EZR CDK6 DKK1 ITGA2 GPR87 MUC1 AHNAK CCND1 SERP1 RRM2 AREG NOTCH2 KRAS HBEGF FOSL1 CEP55 AJUBA PMC11680093__F6 Induced Pluripotent Stem Cells in Birds: Opportunities and Challenges for Science and Agriculture TSC2 BAD RICTOR TSC1 GSK3B PTEN MTOR CCND1 PMC4956935__F2 Proposed IGF‐interaction with PPAR‐G signalling in CVD epigenetics RHEB TSC2 TSC1 MTOR PMC3882377__F6 Schema of our hypothesis CD36 SHH SMO PMC5895694__F1 Cross talk between CEA, TGFB signaling, and IL6-STAT3 pathway TGFBR2 STAT3 SMAD4 TGFBR1 PMC4546315__F1 The insulin/IGF1R signalling pathway IGF1R GRB2 IRS1 PMC4356074__F3 Canonical and non-canonical Wnt signaling pathways APC GSK3B ARHA PMC4070521__F1 Biosynthetic pathway of n3 and n6 PUFAs highlighting a set of genes known to play key roles in the biosynthesis and metabolism of LC-PUFAs in two parallel and competing pathways HEL-S-5 GLA FADS2 FADS1 PMC6475556__F7 The mechanisms of total triterpenes of the E BAX TLR4 NQO1 PMC4103158__F3 Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns HEL113 TNNI2 TCAP HEL-S-273 HMGCL MYH6 DBT ACTN2 CS TNNI1 TPM1 MYL1 SUCLG1 SUCLA2 MYL3 tmp_locus_29 TPM3 MYL2 HEL-S-108 DMD MDH2 ETFDH TNNT3 FH TNNC2 ACO2 SDHA SDHB IVD DLD MYH8 MYL4 PMC8275185__F8 Transcriptome Analysis of Chloris virgata, Which Shows the Fastest Germination and Growth in the Major Mongolian Grassland Plant BIN2 BAK1 CPD PMC6599049__F6 Proposed mechanism for antiviral activity of manassantin B toward coxsackievirus B3 TBK1 CGAS IRF3 PMC11989106__F1 MTOR signaling pathway: The mTOR signaling network consists of two branches, each mediated by a specific complex, mTORC1 and mTORC2 RHEB TSC2 TSC1 LARP1 PTEN DEPTOR EIF4E PMC4248024__F1 The NAD pathway model NNMT PNP NRK NAPRT PARG NADK PMC6356085__F6 Network analysis identified RABEP2 as an important protein in inflammatory and signaling pathways implication in the development of inflammation and cancer GALNT3 SRPRB RPL31 SMS SRP14 HEL-S-310 UNC13D FKBP3 RABEP2 PDLIM3 CHUK RPL4 SRC PMC9284958__F1 Comprehensive network map of IL-17A signaling pathway STAT1 LIF RELA PMC9170606__F2 Twists and turns of the genetic story of mevalonate kinase-associated diseases: A review PMVK MVD FDPS MVK PMC10742340__F1 Molecular signaling pathways associated with Mn neurotoxicity STAT3 BAX CGAS PINK1 PTEN IRF3 TNF RHEB NLRP3 IL18 EIF2A BDNF SIRT1 PMC5722193__F2 Acute metabolic effects of AMPK activation TSC2 CD36 PFKFB2 MTOR PMC5207000__F2 Genetically decreased vitamin D and risk of Alzheimer disease CYP2R1 CYP27B1 CYP24A1 GC DHCR7 PMC8553772__F7 Schematic demonstrating p32 regulates melanoma via AKT/PKB signaling CDH2 MMP9 CCND1 PMC7379631__F3 UPR disease biomarkers and therapeutic targets CREB3L3 RTCB PDIA5 FOXO1 SREBF2 HIF1A ATF4 YY1 EIF2A TRAF2 PMC4593375__F1 The primary epidermal growth factor receptor (EGFR) signaling pathway EGFR PTEN GRB2 MTOR PMC10894836__F4 MiRNAs in Müller cells on retinal regeneration KLF4 TPM1 DKK3 CRX HSPD1 ITGB1 LIN28A CTDSP1 SOX2 PMC10894836__F2 MiRNAs on gliogenesis CCND3 HMGA2 SOX9 NOTCH3 PMC11234281__F2 Piezo1 located in different cells regulates bone formation CD80 PIEZO1 THBS1 DMP1 NFATC1 MTOR VEGFA PPP3CA ARHA RUNX2 RUNX3 CTNNB1 MYD88 SOST FAM20C EDN1 ROCK1 BMP2 HP NOTCH3 TNFRSF11B CD68 PMC3238182__F1 Involvement of miR-221/222 as downstream effectors of the EGFR-RAS-RAF-MEK pathway in progression of metastatic transformation of breast cancer tumors TRPS1 EGF FOSL1 EGFR ZEB2 GRB2 PMC8425390__F3 Reusability and composability in process description maps: RAS–RAF–MEK–ERK signalling HRAS RAF1 BRAF HEL-S-1 PMC5801557__F1 Parathyroid tumorigenesis mechanisms via the cyclins pathway CDC73 MEN1 CDKN1B CCND1 PMC8425390__F1 Reusability and composability in process description maps: RAS–RAF–MEK–ERK signalling HRAS BAD RAF1 EGFR BCL2 HEL-S-1 GRB2 PMC3116046__F2 Increased expression of DNA repair genes in invasive human pancreatic cancer cells MSH6 ATR RAD51 MSH2 BRCA2 FANCA FANCC FANCE BARD1 IFNG FANCD2 BACH1 MRE11A BRCA1 ATM ATF1 PMC5369312__F4 Pediatric Ependymoma: A Proteomics Perspective HMGB1 TAPBP HEL113 CANX SP1 HEL-S-67p JUNB MCL1 HEL-S-269 MPO HEL-S-99n BCL2L1 YWHAQ FOSL1 GDF15 TP63 HLTF ENO1 HBB YWHAZ PMC7519545__F1 ABCA1 cell signaling pathways TLR4 ABCA1 MERTK MYD88 PMC5822899__F2 Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue CD40 IFNG RXRA IL6 VCAM1 PMC5822899__F1 The main intracellular pathways and the effects of drugs used in dyslipidemia and obesity in (A) differentiation of preadipocytes into mature adipocytes LPL TG PDE3B CD36 GC PMC7044792__F1 Extrinsic pathway of apoptosis TRADD TNF FADD PMC7044792__F4 HIV-1 and necroptosis RIPK3 MLKL IL18 RIPK1 PMC8632052__F5 Chronic Circadian Rhythm Disturbance Accelerates Knee Cartilage Degeneration in Rats Accompanied by the Activation of the Canonical Wnt/Beta-Catenin Signaling Pathway IL1B CTNNB1 PMC4694980__F4 Core of kinase-regulated interactomes defines the neoplastic MDSC lineage SDHB MTDH HEL-S-130P NPM1 TPO CBX3 AHNAK PMC8707860__F7 VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway MYOG VEGFB PCNA MTOR PMC4694980__F6 A core of kinase-regulated interactomes defines the neoplastic MDSC lineage TRIR ANXA4 MB PMC4694980__F3 A core of kinase-regulated interactomes defines the neoplastic MDSC lineage HNRNPL ARHGAP1 LRPAP1 BASP1 ACTN4 HNRNPK PMC4694980__F2 A core of kinase-regulated interactomes defines the neoplastic MDSC lineage HEL57 MB NDUFA10 SERPINB6 PMC4142901__F1 Hh signalling and cancer: Growth factors can increase the concentration of ligand which prevents the inhibitory effect of PTCH KIF7 SUFU GSK3B DHH SHH IHH BCL2 MSX2 GLI3 PMC2892843__F3 Dual MAG receptor model LINGO1 ARHA PMC8042594__F1 Monocytic and macrophage contribution to SARS-CoV-2 hyperinflammation STAT3 SOCS3 JAK1 ACE2 IL1B PMC9499417__F1 IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy STAT3 BAX STAT1 BAD JAK3 GSK3B BCL2 MTOR JAK1 PMC10489547__F3 Main signaling pathway of cell division cycle 20 homologue (CDC20) in cancers STAT3 MIIP NUSAP1 CDC20 WNT3A MYBL2 SOX2 UBE2S WNT1 ANAPC2 CCNB1 VHL PMC4999903__F8 Sinularin-induced apoptosis in the AGS and NCI-N87 gastric cancer cells BAX BAD GSK3B MTOR PMC8595028__F1 Rh-CXCL-12 Attenuates Neuronal Pyroptosis after Subarachnoid Hemorrhage in Rats via Regulating the CXCR4/NLRP1 Pathway NLRP1 CXCL12 CXCR4 PMC9072740__F4 Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context TF SLC3A2 AIFM2 GPX4 LPCAT3 FACL4 PMC6054262__F1 O-GlcNAcylation regulates oxidative stress signaling pathways OGA KEAP1 GCLM SLC7A11 PSMB2 SQSTM1 ME1 AKR1B10 VHL HMOX1 FTH1 FOXO4 FOXO1 GSTA4 NQO1 RELA GCLC MDM2 PMC8185510__F6 Autophagy inhibition and microRNA-199a-5p upregulation in paclitaxel-resistant A549/T lung cancer cells EEF2K MTOR ATG5 PMC9103474__F2 Oral Microbiota-Driven Cell Migration in Carcinogenesis and Metastasis STAT3 EGF OLFM4 NNMT RGCC GSK3B PTEN ZEB2 NLK CTNNB1 PMC3429622__F4 TRBP in the exogenous and endogenous RNAi pathways DGCR8 AGO2 DROSHA PMC4001781__F3 Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma ARAF BRAF NRAS PMC4909198__F7 Transcriptome Sequencing and Analysis for Culm Elongation of the World’s Largest Bamboo (Dendrocalamus sinicus) CAD HEL-S-62p PMC5354844__F5 The function of cancer-shed gangliosides in macrophage phenotype: involvement with angiogenesis JAK3 CCR2 ARG1 PMC3166354__F1 Cellular and Molecular Action of the Mitogenic Protein-Deamidating Toxin from Pasteurella multocida CDC42 CEBPA PIM1 EGFR PLCB1 ARHA JAK1 RAC1 NOTCH1 CTNNB1 PMC3288643__F1 Ephs and Ephrins in Cancer: Ephrin-A1 Signaling EPHA2 PTEN PMC8060460__F1 Process of neddylation modification of proteins UBA3 TGFBI SMURF1 EGFR PTEN NAE1 UBE2F MDM2 PMC9035666__F4 Dan-Shen-Yin Granules Prevent Hypoxia-Induced Pulmonary Hypertension via STAT3/HIF-1A/VEGF and FAK/AKT Signaling Pathways MAPK1 MAPK14 STAT3 PIK3CA JUN RELA PIK3R1 SRC MYC TNF MAPK3 PMC3533463__F1 Biosynthesis pathways of phospholipid components in archaea IDI2 GIP MVK PMC3882864__F1 The variety of stimuli that can up-regulate NKG2D and DNAM-1 ligands ATR ATM MICA MICB PMC7914548__F2 Host mucosal responses to C IL16 S100A8 CCL20 PMC3937043__F5 Ingenuity Pathway Analysis (IPA) of the 39 differentially expressed genes in MFG transcriptome at 18 hpi vs ZFP36 EGR1 BCL2A1 SERPINA1 CTSZ GADD45A IL1B PMC2698645__F1 Simplified schematic representation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway driven by muscle contraction, insulin, essential amino acids (leucine), and/or energy RHEB RPS6 EEF2K TSC2 MAP4K3 TSC1 EEF2 PMC6220322__F8 Metabolic enzymes that characterize the progression from a normal liver to cirrhosis, which culminates in HCC HEL-S-133P HK2 COX5A LDHB SDHB PDHA1 HEL-S-304 ALDOB UQCRB FBP1 PFKL HEL-S-87p NDUFA5 PMC2698645__F2 Simplified schematic representation of the interaction between the mTORC1 and ERK1/2 signaling pathways following muscle contraction and/or insulin stimulation RHEB RPS6 EEF2K TSC2 TSC1 EEF2 PMC8818599__F7 Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting STAT3 SOCS3 IRS1 FBXO32 PMC7904555__F2 Intracellular trafficking pathways of TLR4 and TRAM TLR4 ARF6 VPS33B LYST GMFG PMC7904555__F1 Pro-inflammatory signaling pathways of TLR4 NLRP3 TIRAP TLR4 CD14 IRF3 IRF7 TRAF3 TRAF6 LBP IL1B MYD88 PMC5061788__F1 mTOR signalling pathway EIF4B RICTOR MTOR EIF4E PMC4171604__F8 Anti-neoplastic properties of hydralazine in prostate cancer EGF EGFR SRC PMC2702500__F1 Metabolic reconstruction of Db FH HEL-S-133P C2 SUCO PMC7352732__F2 Ferroptosis is the result of an accumulation of lipid reactive species SLC3A2 GPX4 ASPH SLC7A11 PRODH PMC7671541__F6 ED-71 inhibiting NLRP3 inflammasome-dependent pyroptosis in HGFs GSDMD NLRP3 IL16 TLR4 PMC8511224__F2 WNT4 signaling pathway JUN APC ROR2 ATF2 ARHA DAAM2 UNK DAAM1 CTNNB1 PMC9102468__F1 LINC00665: An Emerging Biomarker for Cancer Diagnostics and Therapeutics CIP2A U2AF2 SP1 EGFR SMAD2 APC LRP5 LRP6 NLK AKR1B10 CTNNB1 PMC7018995__F3 Correlation of molecular mechanisms in CTCL and NSCLC and corresponding simulation results BMI1 HDAC1 BCL2 ATM PMC6405444__F2 Major pathways converging on uncontrolled growth in Drosophila epithelial cells SCRIB MYC PMC7913953__F3 Over- and under-expressed genes are enriched in the human cell cycle pathway STAG2 DBF4 CDC20 PCNA CDC6 STAG1 SMC3 SMAD4 MYT1 PLK1 INS SKP2 CDK7 CDK2 MDM2 PMC7352732__F4 K-ras transcription regulation roadmap SLC3A2 SIK1 HOXC10 KEAP1 HEL-S-133P GPX4 SIK3 CRTC2 SLC7A11 MTOR ATF3 BACH1 CAMKK2 HEL-S-68p HEL-S-162eP PLAG1 ADRB2 ENO1 ATF4 PALB2 PMC5817859__F2 Alternative downstream compounds-induced EGFR-TKIs resistance EGR1 EGFR PTEN MTOR PMC3834200__F7 MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells STRA8 GDNF RET PMC4946798__F2 Probing the complexities of astrocyte calcium signaling TRPM2 MCU PMC5731952__F7 Comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis OBSCN ARHA RHO CTNNB1 PMC6372765__F1 Signaling pathways involved in sarcopenia , EIF4B FBXO40 IGF1 GDF11 SMAD2 GSK3B IGF1R MTOR IRS1 CTNNB1 EIF4E PMC12001728__F3 Intricate regulatory mechanisms of programmed death 1 in tumor cells FUT8 MDM2 MTOR PMC11076696__F3 GLP-1RAs in reducing macrophage inflammation and foam cell formation GSDMD NLRP3 MTOR CEBPB NOX4 UNK PMC11076696__F2 GLP-1RAs in protecting endothelial cell function VCAM1 TNF PMC8294576__F3 Mitochondrial metabolism regulates macrophage biology CGAS NLRP3 TLR9 IRF3 HIF1A RET IL1B PMC10887252__F5 Molecular mechanisms for the involvement of the JNK pathway in insulin resistance NR1C1 NCOR1 FGF21 ATF2 IL6 IRS1 PMC7352595__F9 Biosynthesis pathway of phenylpropanoid in P CAD CCR7 PMC6305585__F4 APOBECs-mediated RNA editing in cancer development WT1 APOBEC1 NF1 APOBEC3A NAT1 PMC6305585__F7 APOBEC1-mediated RNA editing in metabolic disorders APOBEC1 APOE UNK PMC6305585__F6 ADAR2-mediated RNA editing in metabolic disorders CRY2 FLNA PMC7545690__F1 Flow chart for selecting SNPs in the folic acid metabolic pathway genes FOLH1 MAF TYMS PMC9693075__F1 Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss EGF EGFR GSK3B SHH SMO CTNNB1 PMC6449083__F10 ANAC044/ANAC085-mediated pathway involved in stress-induced G2 arrest ATR RAD51 MND1 BRCA1 ATM PMC7456948__F1 MSCs in regulating the IL-10 producing regulatory B cells IL10 EBI3 MSC PMC6305585__F3 ADAR2-mediated RNA editing in cancer development RAP2A PCDH9 ACTN4 SLC22A3 ADAM12 AMFR IGFBP7 COPA SKP2 PMC6305585__F2 ADAR1-mediated RNA editing in cancer development GABRA3 TH STAT3 SUFU RSF1 DHFR BLCAP PC CCNI MB PRUNE2 TGFBR1 PMC7429633__F2 Pathway to protein phosphorylation and cysteine modification of sarcoplasmic reticulum Ca2+ handling proteins RYR2 PLN CP PMC8068766__F4 Transcriptome profiles associated with selenium-deficiency-dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells CENPM POLD3 TIMELESS DTL SPARC SLC27A2 DUT MTOR ORC3 FOS ORC2 SET GINS4 CDCA3 GNS IL2 RRAGA PMC3143653__F6 Ingenuity pathway analysis of PKCAlpha-CT regulated, MEF2-targetted cardiac mRNAs PPARG SYK ENO2 IL13 AIP IL4 TNS1 TNF ATF3 SPRR1A KIF6 CEBPB LAT2 PMC8884377__F1 Endothelial-Mesenchymal Transition or Functional Tissue Regeneration – Two Outcomes of Heart Remodeling CDH2 VWF STAT3 TGFBI ACE2 PMC5863502__F2 Beneficial effects of immunobiotics on the antiviral innate immune response against rotavirus in bovine intestinal epithelial (BIE) cells MAVS TLR3 STAT2 IRF3 MPC1 JAK1 IFNA1 TYK2 PMC5863502__F1 Antiviral Innate immune response against rotavirus in bovine intestinal epithelial (BIE) cells MAVS TLR3 STAT2 IRF3 MPC1 CXCL10 TRAF6 IFNA1 PMC11975626__F2 Interactions between immune cells and cancer‐associated fibroblasts (CAFs) STAT3 ACTA2 CXCL12 TLR4 CXCL5 CCR2 MMP2 IL8RB CXCR4 CCL2 CYLD PMC4452922__F7 IFN pathway in response to virus infection at 24 hpi IFNG BAX PSMB8 IRF9 PIAS1 IRF1 PMC11975626__F4 Exosomes between urinary system tumours and cancer‐associated fibroblasts (CAFs) SOCS1 STAT3 HGF HNRNPA2B1 HMGA2 RNF43 EGFR GREM2 MTOR ABCB1 PMC11975626__F3 Symbiotic relationship between cancer‐associated fibroblasts (CAFs) and prostate cancer (PCa) ACLY MTOR SIRT1 PMC8275185__F5 Transcriptome Analysis of Chloris virgata, Which Shows the Fastest Germination and Growth in the Major Mongolian Grassland Plant RGL3 PMC5807036__F2 Tumorigenic proteins significantly upregulated in the IMR-32 cells mapped to the MYCN proto-oncogene, bHLH transcription factor (MYCN) pathway FLI1 SP1 INSR IL3 L1CAM HIF1A ANGPT2 MYC KITLG EIF4E PMC9726313__F8 Network-based pharmacology and molecular docking exploring the “Bupleuri Radix-Scutellariae Radix” mechanism of action in the viral hepatitis B treatment FAS IL18R1 TRADD SELE ITCH MLKL JUNB CXCL2 SOCS3 TRAF3 NOD2 TRAF2 FADD PMC3555235__F4 Predicted pathways by the Ingenuity Pathway Analysis software (IPA) according to microarrays results in peripheral blood mononuclear cells (PBMCs) HPSE RNF7 MAFA IL3 DBT CD7 ATF2 PSEN1 WNT10A MAPK14 STAT1 DRD2 SHH MDM2 ZFP36 CRYAA CLCF1 MIA GFAP IL17C COL18A1 VPREB1 GSC BDKRB2 CYBB KLF2 TRH CCL22 CD36 GAS RARA CX3CL1 APP SENP2 GBP2 BAX MEOX1 IL13 PTPRN CD14 NFATC1 CXCL6 NR3C1 FOXF1 NPPA HMGA1 CAMK2D HEL-S-102 NFKBIA CREBBP VSX1 TMOD2 BIRC2 PMC4377021__F5 Pathway for a network related to cell to cell signaling process in the anaplastic thyroid carcinoma KDM1B PLAUR GFPT1 MRC2 HTATIP2 TGFBR1 SPP1 CSNK1E RECQL IRAK3 SCD5 HAS2 ITGB5 SDC2 PMC4765324__F5 Programming and reprogramming neural cells by (endo-) cannabinoids: from physiological rules to emerging therapies ATF3 NGF TRPV1 ATF4 TRIB3 PAX6 CTNNB1 PMC3852811__F1 Metabolic networks of longevity IGF1 PTEN HIF1A INS PMC5102790__F2 Merkel Cell Polyomavirus Infection and Merkel Cell Carcinoma EGF MCC CR1 CTNNB1 PMC3163765__F2 Signal Transducer and Activator of Transcription 5a/b: Biomarker and Therapeutic Target in Prostate and Breast Cancer STAT5B PMC12086171__F8 Differentially expressed genes in memory CD4+ T cells from donors expressing HLA-DRB1 alleles ZAP70 FAS TGFB1 CCL3 NKG7 CD27 LAT TXK KLRF1 IL15RA CXCL8 IFNG KLRC1 HEL-S-171mP TRAT1 KLRC3 LAG3 GZMK KLRK1 GZMA IL7R CXCL2 CTLA4 LTB TIGIT IL1RN KLRG1 BOLA1 BCL2 CCL4 BTLA IKZF2 CCL20 PMC9271624__F2 Primary Cilia in Pancreatic Beta- and Alpha-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme TH APC GIP SMO RHO PMC3044438__F3 Identifying genomic and developmental causes of adverse drug reactions in children MTHFD2 ADORA2A FOLH1 DHFR MTRR TYMS HEL-S-70p HEL-S-51e MTHFD1 SHMT1 BHMT2 MTHFD1L SLC25A32 HEL-S-61p GGH ABCG2 MTR AHCYL1 FPGS PMC6508100__F2 MCD genes and cytoskeletal regulatory pathways DAB1 DCX RAPGEF2 CDK5 MAP1B VLDLR MAP2 RHO EML1 NDEL1 PMC4478577__F1 Gut-brain axis for the actions of glucagon-like peptide-1 MEA1 NTS DPP4 PMC2546860__F2 Glycerol biosynthesis and other major pathways contributing to cytosolic NAD+/NADH balance in S HEL-S-49 NDE1 GPD1 PMC9396495__F2 Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma LTB LPA C2 CTSO PMC5216734__F8 Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1 RAN AGO2 SRC PMC6085545__F8 Primary DAEC expansion and differentiation.(A) Proliferating human DAECs and their fate after induction and feeder removal in vitro FGF7 EGF FGF10 SCGB1A1 AQP5 PMC8313741__F8 miR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression SOX2 SIRT1 PMC8693501__F8 Extracellular HMGB1 interacts with RAGE and promotes chemoresistance in acute leukemia cells ATG101 BCL2 MTOR PMC3296207__F1 Intrinsic and exrtinsic pathways of anoikis BAD BMF BIK DIABLO FADD PMC7695009__F3 Biosynthetic pathways of UDP-GlcA and UDP-GlcNAc GNPNAT1 UGDH PGM3 PMC84262__F1 IL-1 signaling pathway IRAK2 TRAF6 MYD88 PMC7695009__F5 Overall view of HA roles in the cancer metabolic pathway OGA CD44 OGT PFKFB2 PMC7139586__F5 The proposed role of nAChR signaling pathways in ISC function SMAD1 ID2 AFP AMOT APC SMAD4 AREG GPR49 PMC9117997__F1 Metabolism and subcellular enrichment of phosphoinositides FIG4 INPP4A INPP4B PTEN OCRL PIKFYVE PMC5267336__F1 Clinical applications of mouse models for breast cancer engaging HER2/neu EGF PTEN MTOR MYC CCND1 PMC2679302__F2 Network contains downregulated genes and identified around NFKB gene MADD SAA1 PYCARD HLA-F PMC5059871__F2 Osteosarcoma cell proliferation is regulated by lncRNAs, including H19, MALAT1, ANCR, and PACER PCNA CDK2 ARHA CDK4 PMC6693703__F1 Mutation‐driven (ligand‐independent) activated Hh pathway in BCC development and invasion SUFU PTCH1 SMO GLI3 PMC4930918__F1 p53 integrates metabolic stress signals to direct cell metabolism RHEB TSC2 FAS TSC1 PTEN MDM2 PMC4930918__F3 p53 directs lipid and amino acid metabolism during stress ACLY FAS CPT1C EIF2A ACAD11 PMC4930918__F2 p53 regulates carbohydrate metabolism during glucose starvation ME2 F2 TIGAR SCO2 ME1 PDK2 GLS2 PMC5818965__F1 Metabolic changes triggered by ischemic insult and possible evolutions of the injury with the crosstalk between chemokines XCL2 CXCL2 CCL5 CCL2 TNF CCL1 CXCL3 PMC3061571__F2 Two different ubiquitin ligases control the stability of the Aurora-A and Polo-like kinases CDC26 CHFR CDC20 APC PLK1 PMC7683515__F2 Signaling pathways up and downstream of mTOR complexes RHEB TSC2 TSC1 RAF1 STAT5B GRB2 PMC11552340__F3 Compounds that target components of WNT pathway TNKS APC CTNNB1 PMC11552340__F1 WNT signaling pathways affected by WNT6 in cancer STAT3 JUN APC ROR2 PTK7 RYK ATF2 ARHA CTNNB1 PMC8298276__F1 Drugging multiple same-allele driver mutations in cancer ERBB3 EGF EGFR MTOR PMC3149979__F1 A representative immune response pathway that leads to the disruption of viral release from the plasma membrane IRF3 IRF7 PMC11505556__F11 Therapeutic effect of baicalein against insulin resistance (IR) INSR MTOR IRS1 PMC6344597__F6 The amino acid catabolism pathway differs in breast-fed (BF) and formula-fed (FF) infants HEL-S-62p C2 PMC6273039__F4 The molecular metchanisms of natural polyphenols effects on metastasis CDH2 GRAP MTOR PMC3851989__F4 Identification of mutated core cancer modules by integrating somatic mutation, copy number variation, and gene expression data RAD52 CCNE1 MYC PMC2905316__F2 Involvement of the Notch signaling pathway during endocrine cell differentiation NEUROD1 MMD HES1 PMC3851989__F3 The fourth module identified by iMCMC in the GBM data and locations of the detected genes in known pathways NF1 EGFR ChAT SLC18A3 MDM2 PMC11085419__F5 Gallic Acid Can Promote Low-Density Lipoprotein Uptake in HepG2 Cells via Increasing Low-Density Lipoprotein Receptor Accumulation PCSK9 FOXO3A EGFR WAS LDLR HNF1A PMC12133496__F2 Simple signaling pathway map of SLC7 transporter protein changes affecting Beta-Cell Function and corresponding islet reactions RHEB TSC1 IRS1 PMC9577001__F2 Cancer-associated mesothelial cells in the progression and therapy of ovarian cancer CD44 STAT3 CD24 CCR5 CCL2 PMC9577001__F1 Cancer-associated mesothelial cells in the progression and therapy of ovarian cancer LPA CD44 HGF CCL21 c-fgr VAV2 ITLN1 CXCL5 SMAD2 GRB2 DLX4 RAC1 PMC5711377__F3 Pathview () plot of the KEGG () pathway showing the Cell mitotic cycle ('HSA 04110') superimposed with RNA-seq expression data corresponding to the log2 -transformed fold change in expression of cell cycle transcripts from HIOs microinjected with E PCNA E2F4 CDC45 PRKDC WEE1 ATM HEL-S-1 CCNA2 CCNH PMC6095977__F1 IRF9 signaling via the JAK–STAT pathway and antagonism by viral proteins STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC3170851__F2 The Multifaceted Roles of Autophagy In Tumors--Implications For Breast Cancer NBR1 KEAP1 COIL PMC4840027__F2 Quantitative regulation by the TCF/Beta-catenin asymmetry pathway TF POR SYS1 POP1 PMC12131380__F7 Working model of this study PRLR PRL CCND1 PMC7440025__F2 Major antiviral functions of TRIM proteins TRIM14 TRIM28 TRIM25 TRIM41 TRIM2 TRIM6 TRIM23 PMC6099292__F5 Ubiquitylated sites in proteins revealed by diGly proteomics in PC9/GR cells SNAP23 TRIM32 ABCC1 EGFR VAMP3 PML STX19 PRKCB TGFBR1 VAMP7 GNAS TFRC CLTA TAP2 STX3A CLTC ABCC2 PRPF19 VPS37A TSG101 CHMP2A CLN3 USE1 RAB11B ITGB1 ABCA2 CDC27 HLA-C PS1TP5BP1 PMC4711826__F7 Molecular explanation SMAD2 SMAD4 YAP1 SPP1 TGFBR1 PMC6198212__F1 Interactions and functions of NRPs TGFBR2 HGF SRC TGFBR1 PMC9238352__F3 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways CD40 LEP TIRAP CTSK TLR9 CD14 IRF3 TNF MYC IRAK4 RAC1 MYD88 TLR3 PDC NPB REL LBP FADD PMC2585593__F1 Diagrammatic representation of pathways associated with aroma production and links to associated metabolic activities ATF1 ACD ATF2 ADA PMC3991635__F6 Microarray Analysis of Cell Cycle Gene Expression in Adult Human Corneal Endothelial Cells ATR CDC14B TGFB1 PCNA BUB1B GSK3B SMAD4 TBC1D8 SKP2 PLK1 CCNH CCNB3 PTTG2 CCND2 WEE1 ATM MDM2 MAD1L1 YWHAG CCND3 ESPL1 TFDP1 APC MPEG1 HEL-S-30 HEL-S-92n RBL1 PTTG1 PRKDC CDKN1B CDKN1C EP300 UBE2F CDC25B PMC9238352__F5 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways MAX REST SPOP KL DAO HLX PMC5528795__F6 Working model of pyrithione zinc in oral cancer BAX BAD RICTOR MTOR CCND1 PMC9238352__F4 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways LTA TRADD LAT CS TNF POR LTB BCR ATM HEL-S-11 EDAR CYLD LBP PMC5513919__F7 Colorectal cancer metastasis signaling pathway ATR BAD PMC9238352__F7 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways ZAP70 IFNG JUN BATF TIRAP LAT EGFR PTEN TRAF6 LCK PMC9238352__F6 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways BAD PMC3991635__F4 Microarray Analysis of Cell Cycle Gene Expression in Adult Human Corneal Endothelial Cells CDC14B BUB1B GSK3B SMAD4 TBC1D8 CCNA2 SKP2 PLK1 PTTG2 CCNB3 RB1 CDK6 CCNE1 WEE1 MDM2 ESPL1 TFDP1 APC MPEG1 SET CDKN1B CDK2 CDKN1C GADD45A CDC25B ATR TGFB1 CDC20 PCNA CDC6 CDKN2B APC2 CCNH CCND2 CHEK2 ATM CCNB1 CCND1 MAD1L1 YWHAG CDK4 CCND3 MAD2L1 RBL1 PTTG1 CCNE2 PKMYT1 MAD2L2 PRKDC CHEK1 EP300 UBE2F PMC3567494__F1 Two phosphoinositide cycles regulate aspects of lysosome function FIG4 FYCO1 PI3 PC PAH IL1A PIKFYVE PMC8745298__F2 Roles and Mechanisms of the Protein Quality Control System in Alzheimer’s Disease SP1 GLS SP2 ATF4 EIF2A BDNF XBP1 TRAF2 PMC6453877__F3 HIF-mediated suppression of ROS PHGDH GCLM SLC7A11 HEL-S-51e COXFA4L2 PMC6453877__F4 HIF-mediated regulation of mitochondrial mass TFAM BNIP3 MXI1 POLRMT PMC8656474__F2 Molecular Mechanisms of Resistance to Immunotherapy and Antiangiogenic Treatments in Clear Cell Renal Cell Carcinoma IFNG CD80 APC IRF1 CTLA4 LAG3 CTNNB1 PMC6515249__F3 Natural-product-mediated multi-step regulation of the TRAIL-driven pathway BAX STAMBPL1 FADD PMC3207473__F7 Model: TTP transition from “hypo- to hypermodified” determines its functional switch TRADD HEL-S-162eP TRAF2 FADD PMC6515249__F2 Negative regulation of the TRAIL-driven pathway ITCH TRAF6 PMC8791723__F1 Kynurenine Pathway Metabolites as Biomarkers in Alzheimer's Disease IDO1 KYNU KMO IDO2 PMC6515249__F1 TRAIL (TNF-related apoptosis-inducing ligand)-mediated signaling BAX BCL2 PMC6631793__F1 Iatrogenic interference with the initiation of antifungal immunity IFNG SYK BTK CXCR1 BCL10 MAF CS CARD9 PMC9405736__F1 Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage ACLY DGAT1 GLS SCD MAK SQLE FASN ABCA1 ACSS2 HMGCR LDLR SLC25A1 SOAT1 FDPS PMC5748986__F2 Protein sequestration at the nuclear periphery HDAC3 RBBP7 HDAC1 RBBP4 PCNA WRN SMAD2 POLI YY1 AKTIP PARP1 SIRT6 PMC5487527__F3 m6A is involved in viral replicationSchematic representation of the intersection between m6A pathway and viral replication ALKBH5 METTL14 YTHDF2 YTHDF1 METTL3 PMC5487527__F2 Links between m6A regulation and cancerSchematic representation of m6A pathway components and targets involved in cancer progression RARA FOXM1 EGFR ALKBH5 METTL14 GSC METTL3 ASB2 ELF3 PMC7649569__F3 Major milestones in the development of the Hippo signaling pathway HEL-S-11 NF2 CTNNB1 PMC9265087__F3 It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer IFNG TERT MICB TRIM29 MYC PMC12083488__F1 Tryptophan metabolic pathway AHR AHRR PMC6138823__F3 Hepatitis C virus-apolipoprotein interactions: molecular mechanisms and clinical impact ABCG1 LDLR PLTP ABCA1 PMC6470603__F8 Compound 3f exerted anti-pulmonary fibrosis activity via repression of the TGFB/Smad signaling pathway SMAD2 COL3A1 PMC8699381__F3 Endocannabinoid System and Tumour Microenvironment: New Intertwined Connections for Anticancer Approaches BAX EGFR TRPV1 ATM HEL-S-11 ATF2 ARHA GPR55 XBP1 PMC8322984__F9 Targeting Tristetraprolin Expression or Functional Activity Regulates Inflammatory Response Induced by MSU Crystals NLRP3 IL1B PMC5340232__F7 Reduced expression of FILIP1L, a novel WNT pathway inhibitor, is associated with poor survival, progression and chemoresistance in ovarian cancer APC GSK3B LRP5 LRP6 FILIP1L CTNNB1 PMC8117616__F7 Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria HEL164 VWF TSC2 XB RHOB ChAT MDM2 ITGB3 GNG11 CTNNB1 PMC11767231__F4 Inborn Errors of Immunity Presenting with Early-Onset Severe Atopy DOCK8 CARMIL2 WAS WIPF1 ARPC1B PMC11767231__F1 CBM complex controls T cell signaling by the mammalian target of rapamycin (mTOR), nuclear factor kappa B (NFKB), and c-Jun N-terminal kinase activation (JNK) CARD14 CARD11 CARMIL2 MTOR PMC11767231__F2 The JAK/STAT pathways contain various factors, including STAT5, which leads to myeloid activation, or STAT3, which upregulates transcription of the gene ZNF341 STAT3 STAT1 STAT5B ZNF341 JAK1 PMC9687819__F3 Alteration of the IFN-Pathway by Human Papillomavirus Proteins: Antiviral Immune Response Evasion Mechanism CGAS IRF1 IRF3 PMC7983022__F1 Hepcidin and iron homeostasis ERFE HAMP MTOR FURIN HFE2 PMC9687819__F2 Alteration of the IFN-Pathway by Human Papillomavirus Proteins: Antiviral Immune Response Evasion Mechanism IFNK STAT1 CGAS STAT2 IRF9 RSAD2 JAK1 OAS1 TYK2 PMC9233125__F3 Link between inflammatory mediators, autophagy, and metabolic reprogramming TH GOT2 IL24 CXCL2 PMC5053521__F6 Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier HBEGF SPHK2 EGFR PMC9233125__F2 Genetic alterations induce metabolic reprogramming in PDAC RPIA MYC KRAS PMC9233125__F1 Box 1. Molecular subtypes and metabolic reprogramming in PDAC NR2A1 SIX1 HK2 GSK3B SIX4 PMC3734370__F1 Regulated secretory pathway of a model neuroendocrine cell NGF SORT1 CGA SCG2 INSR CHGB POMC MC4R NPY SCG3 AgRP BDNF PMC6499807__F9 Mechanistic scheme of lncRNA lnc-TALC in GBM STAT3 FOXO3A MGMT PMC6694743__F6 Physiopathology of JCPyV in the brain EGR1 SP1 NF1 HIF1A IRS1 PMC7913544__F2 Functional roles of E3 ubiquitin ligases (blue) and DUBs (pink) in the ER stress and ERAD signaling pathway USP14 RNF183 YOD1 USP19 BAP1 BNIP1 UBL4A ATF4 RNF186 EIF2A PMC9656873__F3 COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs TBK1 CGAS IRF3 ACE2 PMC7324671__F7 Proposed working model for IL-21-induced B cell differentiation and IgA-producing plasma cells in porcine Peyer's patches STAT3 STAT1 PAX5 IL21R BCL6 PMC8285903__F8 GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion AXL RAC1 PMC10758279__F2 In Vitro and In Vivo Analysis of Neurotrophin-3 Activation of Arf6 and Rac-1 TIAM1 TAMALIN ARF6 BDNF PMC4900611__F7 HCV-Mediated Apoptosis of Hepatocytes in Culture and Viral Pathogenesis HTRA2 BAX BAD CASP2 TRADD MCL1 CYCS GAS2 PARP1 HUWE1 NGF CASP4 DFFA BCL2 BOK APP CRADD BAK1 TRAF2 CASP10 BIK DIABLO FADD SPTAN1 PMC6971376__F4 Pleiotropic role of miR-486-5p in manipulating several target genes in different cellular contexts.miR-486-5p has several targets in different malignant and non-malignant conditions OLFM4 FBN1 SMAD2 PLAGL2 PTEN TWF1 GAB2 DOCK1 PMC9656873__F1 COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs NLRP3 CDK2 IRF3 ACE2 PMC7574589__F1 Scheme of mannose metabolism in MPI deficient cell APP PMC2956378__F7 Thrombin-induced ET-1 secretion in RPE is rho/ROCK1/2 dependent GATA2 ROCK2 ROCK1 GATA4 PMC8919593__F8 Extracellular signal-regulated kinase regulates microglial immune responses in Alzheimer’s disease CTRL JUN FAS ATF2 PMC11521927__F3 Various signaling pathways activated by TGFB1 stimulation and their partial cross-talk are outlined TRAF4 SMURF1 SMAD2 SPSB1 SMAD6 SMAD4 HEL-S-28 PTEN GRB2 SMURF2 TRAF6 PMC7820616__F7 Survival of salivary gland cancer stem cells requires mTOR signaling BMI1 RICTOR MTOR PMC11941073__F1 GOLPH3 regulates the spatial distribution of glycosyltransferases within the Golgi cisternae GOLPH3 ST6GAL1 MTOR PMC4276909__F1 miRs regulate vascular medial calcification ALK RUNX2 PMC6433576__F1 Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression APC HNRNPK PMC2810550__F2 Wnt signaling pathway involvement in cancer and neurodegeneration APC LRP5 LRP6 CTNNB1 PMC12065877__F1 Differentially expressed transcripts mapping to the canonical HIF-1A signaling pathway in shunt PAECs, as mapped by Ingenuity Pathway Analysis Canonical pathway analysis, p-value of TF RPS6 NOS2 RAN JUN TGFA ADM COPS5 EPO HIF1A NCOA1 IGF2 VHL EIF4E RBX1 ARD1A CDKN1A APEX1 FOXP3 MDM2 ELOC PMC8531525__F1 Targeting Microglial Alpha-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease SIRT3 NLRP3 TLR4 SNCA PMC4259953__F3 Possible mechanisms of expression and functional regulation of tissue factor and coagulation factor VII in breast cancer cells TF EGR1 EGFR F3 USF1 PTEN MTOR PMC4792035__F1 Emerging functions of amphiregulin in orchestrating immunity, inflammation and tissue repair EGF HBEGF TGFA EGFR BTC AREG PMC4867399__F2 Illustrated summary of Hedgehog pathway and its effetcs at different stages in the formation and progression of ductal pancreatic carcinoma CXCL12 RAF1 SHH SMO IL6 CXCR4 PMC4270428__F1 Multitask Learning of Signaling and Regulatory Networks with Application to Studying Human Response to Flu HEL113 PCNA TRIM2 MYC KHDRBS1 STUB1 FOSL2 TRIM28 SOX9 SP4 NPM1 SP3 ATM MDM2 POLR2A COMMD1 HEL-S-101 SIAH1 SP1 CRKL TUBB BHLHB2 CRK CEBPA DDB1 TRIM25 MVP RELA CREBBP POU2F1 UBE2I PS1TP5BP1 NCL PMC6393348__F2 Activated STAT3/5 signaling pathway by IL-6 receptor, Prolactin (PRL) receptor, VEGF Receptor, EGF Receptor, and IL-10 receptor PRLR STAT3 EGF PRL EGFR PMC3412972__F2 Proteins and protein isoforms in glycolysis/gluconeogenesis, TCA cycle, pentose phosphate pathway, galactose metabolism, and glutamine metabolism pathways HEL107 GLS HK3 CS SRM GCK PFKM G6PC2 FH ACO2 HEL-S-133P LDHB GALK2 PCK2 RPE ALDOB RPIA FBP2 PFKP PGM2 SUCLG2 FBP1 DLD ENO1 PFKL HEL-S-87p PMC7894404__F1 Model‐Informed Pediatric Dose Selection for Dapagliflozin by Incorporating Developmental Changes UGT1A9 CYP3A4 UGT2B7 PMC12059460__F6 HPE inhibits allergic rhinitis by modulating the AMPK/SHP1/SHP2/STING signaling pathway TBK1 SYK EGFR PMC7672255__F2 CYP1B1 as a therapeutic target in cardio-oncology AHR CYP1B1 PMC12163474__F14 Efficacy and Safety of Natural Apigenin Treatment for Alzheimer's Disease: Focus on In vivo Research Advancements ACHE BAX SIRT3 STAT1 GFAP BACE1 BCL2 APP TNF IL1B PMC6066739__F1 ERA subcellular localization allows the activation of both nuclear and membrane-initiated signaling pathways TF SP1 SRC PMC6672276__F11 Regulation of vasopressin gene expression in the SCN VIP PMC9570066__F7 Dietary Koumine on Growth Performance, Intestinal Morphology, Microbiota, and Intestinal Transcriptional Responses of Cyprinus carpio STAR RAF1 FOS PMC11543427__F3 The formation of VSMC-derived foam cells induced by ox-LDL TREM2 CD36 TFEB LYN ABCA1 SIRT6 PMC8198168__F2 Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer GLS KDM3A EZH2 MTOR MYC KDM4C PMC8198168__F1 Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer KDM1A FAS GLS HEL-S-133P PMC5656721__F3 Interplay in the synthesis and actions of the 2-acylglycerols and ethanolamides derived from ARA, DHA and EPA PTPN22 TRPV1 ABHD4 GPR55 PMC8642436__F6 A potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway HMGCR FASN MTOR PMC4581242__F1 UPRmt models in mammalians HTRA2 NDUFB2 YME1L1 CLPP EIF2A NRF1 PMC2527273__F2 The signaling pathway of Type II, FasL signaling-induced apoptosis, adapted from Bagci et al BAX CASP9 CASP8 CASP3 PMC10152985__F15 Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications WWP1 UBA5 RBX1 UBA7 FBXW7 UBC NEDD4 TRIM25 UBA6 BAP1 SKP2 HUWE1 PMC4365348__F5 Shared pathway/ GO categories for DEGs from liver and skeletal muscle tissues RPS21 EIF4B RPS23 EEF1G VHL MAPK3 MAPK14 RPS26 RPS29 FAU RELA RPS12 EIF4A1 PMC7873896__F4 Therapeutic molecules that target Wnt signaling pathway at the level of the plasma membrane DKK1 LRP5 WNT1 LRP6 PMC9421153__F5 Targeting TRAF3IP2 inhibits angiogenesis in glioblastoma EGF EGFR IL6 MTOR VEGFA IL6R IL1B FGF2 PMC7873896__F2 Wnt signaling pathways at the plasma membrane RNF43 APC GSK3B LRP5 CDK14 LRP6 RYK GPR49 CTNNB1 PMC11983633__F6 Ribosomal protein L9 is a potential therapeutic target for B-ALL through the activation of the p53 signaling pathway RPL9 MICA MICB PMC2605957__F7 Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway POR HGF CD36 PMC3621649__F1 Targeted therapy pathways.Notes: Protein kinase B (AKT) is a serine/threonine-specific protein kinase that affects glucose metabolism, apoptosis, cell proliferation, transcription and cell migration STAT3 STAT1 STAT2 MTOR PMC7958478__F2 Pathways linking coronavirus disease 2019 to heart/brain injury IL15 IF2B1 IL6 CXCL10 PMC2886346__F10 The pathway signaling to ERESs EGF MAP3K1 NF1 EGFR PMC4957615__F1 Actin and myosins in mammalian autophagy WHAMM HEL-S-62p MYO1C MYO6 OPTN PMC7218174__F3 Autophagic compensation in resistance to MET-targeted therapy HGF GLS ULK1 MTOR PMC4951264__F8 Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways MCL1 CCND1 PMC6999540__F1 An overview of metabolic engineering of Y LPA IPP FAS XK XDH ME1 PEX3 GPD1 TNLG7C PMC2784662__F1 mTOR Signaling Cascade RHEB RICTOR PTEN MTOR ELF3 EIF4E PMC8628461__F5 Comprehensive analysis of miRNA–mRNA regulatory network and potential drugs in chronic chagasic cardiomyopathy across human and mouse ICAM2 CD48 SYK FAS LAT MAL MICA TNF CASP3 RAE1 HEL-S-11 HLA-B GRB2 MICB HLA-C PMC5814270__F5 Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas CDC2 CTF1 RGCC EGFR LIF IL6ST PMC3158334__F1 Possible mechanisms of opioid receptor mediated influence of morphine on tumor growth EGF BAD MOS ARHA SRC CCND1 PMC11177111__F0 miR-1202 regulates BPH-1 cell proliferation, apoptosis, and epithelial-to-mesenchymal transition through targeting HMGCL HMGCL CCND1 CTNNB1 PMC9604112__F1 Etiology of IBD—Is It Still a Mystery? HEL-S-92n APC CCL20 PMC7439917__F1 ACE2 downregulation by SARS-CoV-2 induces pericyte damage and microvascular dysfunction TMPRSS2 ADAM17 ACE2 PMC2633485__F8 Proposed mechanism of PDGF signaling in the lens epithelial cells EGFR GRB2 SRC PMC4394028__F1 TLR/IL-1R, RLR, cGAS, and inflammasome signaling pathways CGAS MAVS MAL AIM2 IRAK1 TLR5 IRF3 IRAK2 IRAK4 MYD88 NLRC4 NAIP NLRP3 TLR3 TLR4 TLR8 IL1B PMC7678304__F3 Literature-based illustration of TNFA signaling pathway in the presence and absence of macrophages STAT3 CASP9 CASP8 PMC8234951__F3 Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer STAT3 BAX MTOR CTNNB1 PMC6660575__F1 Posited mechanistic frameworks implicating dietary carbohydrates and cancer risk IGF1 SHBG PMC8239365__F5 IGFBP2 Is a Potential Master Regulator Driving the Dysregulated Gene Network Responsible for Short Survival in Glioblastoma Multiforme STAT3 AEBP1 JUN EGFR PDGFA IGFBP2 PTEN IGF1R MMP9 MTOR VEGFA STAT1 OSMR MMP2 JAK1 PMC8070923__F2 Main mechanisms by which active skeletal muscle can impact the brain FNDC5 BDNF SIRT1 PMC6212468__F2 Integrin linked kinase (ILK) signaling PTEN HEL-S-11 RHO PMC12067395__F2 Interactions between tumors and copper ATOX1 LOX HEL-S-133P EGFR ATP7B HEL-S-30 MYC CCND1 CTNNB1 HEL-S-44 PMC2873428__F8 Sequencing, Analysis, and Annotation of Expressed Sequence Tags for Camelus dromedarius KEAP1 GSK3B PMC9659858__F1 Clinical implication of genetic composition and molecular mechanism on treatment strategies of HER2-positive breast cancers BAX TSC2 CDK6 TSC1 PAK1 BCL2 PTEN IL6 CCL2 CCND1 CDK4 PMC7459525__F6 The possible FDNCR1-miR-204-TGFBR1 pathway in porcine preadipocyte differentiation SMAD2 TGFBR1 PMC11743317__F6 Signaling pathways of duck RIG-I in gene-edited DF1 chicken cells MAVS TRIM25 TLR3 IRF1 IRF3 MX1 IRF7 PMC6212468__F3 Rho GTPase family signaling MOK WAS HEL-S-11 RHO UNK PMC8431732__F2 Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases JUN FYN SP1 KEAP1 PGAM5 BRCA1 AHR SQSTM1 DPP3 MYC KRAS PALB2 PMC3303610__F3 Ang-(1-7) signaling in cardiomyocytes GSK3B PMC2886330__F1 Simplified diagram of the two major pathways affected by EGFR-mediated signaling in malignant glioma cells EGFR PTEN MTOR PMC6212468__F8 Main effects on pathways in the metabolic syndrome hearts (DKO) versus WT hearts and for both mouse models the effect of ACE-I CEBPA NR1C1 EGR1 FOXO3A NFAT5 RELA TP63 CREBBP ATF2 CREB1 FOS PMC3883963__F3 HMGB1-TLR4 signaling mediates liver I/R injury HMGB1 TLR4 CD14 TNF PMC8849213__F2 Protein C Pathway in Paediatric and Neonatal Sepsis TF TLR4 CD14 PC IL6 LBP IL1B PMC6521864__F3 Synthesis pathway of cardiolipin from lysophosphatidic acid and lysophosphatidylcholine PGP HEL-S-5 PTPMT1 PMC6733035__F1 Lineage of Cytotoxic Innate Lymphocyte Differentiation CILP IL15RA PMC5806469__F5 Extended compartmentalized lignin pathway model in B CAD PMC7060546__F3 Roles of (P) RR in pathways that contribute to oncogenesis, as well as cancer progression and metastasis APC LRP6 MTOR CTNNB1 PMC5806469__F1 Putative lignin biosynthesis pathway with identification of species-specific reactions CAD SI PMC11351712__F7 Graphical abstract BAX H2AX PTCH1 SHH SMO PMC6150077__F1 Diagram of gemcitabine metabolism and proposed mechanisms of gemcitabine resistance RRM1 RRM2 PMC5859839__F7 Pathway o of DXP-ER-positive breast cancer network (blue circle stands for compound target; red diamond stands for pathway; green hexagon stands for herb) CDC42 ZAP70 PPARG SYK RAF1 JAK3 BRAF IGF1R MTOR FGFR2 MAPK14 PLA2G10 BTK INSR AK2 NR3A2 MMP2 IL2 MAPK12 KDR SRC HSP90AB1 NOS2 SELE MAPKAPK2 PTPN11 KIT MMP9 ARHA TNF STS EIF4E HMGCR RXRA CALM1 MAP2K1 GRB2 RADX LCK PMC4519954__F13 Endocytosis signaling pathway EHD3 EGF CBL PI3 VPS25 ARF6 LDLR TSG101 ARHA VPS36 VPS28 PMC4519954__F12 Lysosome signaling pathway NAGPA IDUA GAA NAGA GUSB GNS GALNS ABCA2 AGA PMC4519954__F11 ERBB signaling pathway EGF JUN BAD NRG3 MTOR SHE MYC NRG4 NRG2 CRK NRG1 HBEGF CBL BTC GRB2 PMC4519954__F10 MAPK signaling pathway MAX ECSIT JUN FAS MOS CD14 ATF2 GRB2 TRAF6 DAO FLNA PMC5734789__F8 Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination HDAC1 MBP HES5 PMC7451686__F1 Working model for mTORC1/p70S6K signaling regulation of Beta-TrCP-mediated PD-L1 degradation MLST8 SKP1 MTOR DEPTOR PMC7762487__F8 PPI network and KEGG pathway analysis for the differentially expressed MAM proteins in PSD and PDZ rats MAPK1 ARHG CAPZA2 STX12 APOE GNG12 NEFL HEL-S-30 PSMD2 TMED10 APOO RALA HEL-S-130P OMG COX2 VAPA HEL-S-162eP ND2 EEF1A2 PSAP HEPACAM PMC3444437__F9 C-srcregulating primordial follicle activation and growth through PI3K → PKC → MAPK signaling pathway SI GNAL SRC PMC5805631__F5 Personalized proteomics in proliferative vitreoretinopathy implicate hematopoietic cell recruitment and mTOR as a therapeutic target RPTOR FAS STAR SELE IL13 NGFR IGFBP1 MTOR IL6 IFNG ENG TSLP RICTOR DKK1 PMC3581417__F1 Synthesis of DNA precursors in the cytosol and mitochondria TK1 PMC4973221__F3 Transcriptome landscape of Synechococcus elongatus PCC 7942 for nitrogen starvation responses using RNA-seq POR SDHA PGAM1 RPIA PGM2 PC PMC9329168__F1 Improving Treatment Options for Primary Hyperoxaluria HEL-S-133P DAO PMC11756006__F1 Molecular signaling of nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 priming and activation GSDMD NLRP3 MYD88 PMC7057842__F2 Post-Translational Regulations of Transcriptional Activity of RUNX2 GSK3B PIN1 RUNX2 CDK4 PMC5664350__F4 Summary of intracellular TLR4 signalling in platelets TIRAP TLR4 GC IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC5664350__F3 Summary of intracellular TLR4 signalling pathways in nucleated cells TIRAP TLR4 CD14 IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC153558__F3 Model of the maternal Radar signaling pathway mediating early steps of dorsoventral axis formation SMAD1 DKFZp781O1323 BMP4 BMP7 PMC3743157__F3 RB1 pathway indicating genes with mutations in this series RB1 CDKN2A CDK6 SUFU PTCH1 SMO CDK4 PMC3112459__F1 TGFB signalling pathway and breast cancer susceptibility LTBP2 LTBP1 TGFBR2 SMAD1 TGFB1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 TGFBR1 PMC11756006__F2 Molecular and cellular signaling pathways of nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 in obesity, diabetes, and other metabolic diseases IFNG NLRP3 CD36 TLR4 PMC6314136__F6 Dynamic gene expression profiles of CIK cells involved in the cell cycle and the natural killer cell–mediated cytotoxicity pathway STAG2 DBF4 CCND3 FAS PCNA CDC6 STAG1 SMAD2 GSK3B SMAD4 ORC3 SKP2 ORC2 RBX1 CCND2 CDC45 E2F3 CASP3 CDK2 HEL-S-1 HEL2 PMC8833717__F3 Fluorescence Imaging of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer BAX BAD FAS PMC4701085__F10 Molecular pathways affected by Gcm HEPH NUMB SMO RDX PMC4261819__F1 Network of noncoding RNAs negatively regulates NFKB signaling KLF4 CD40 KLF2 MAP3K7IP1 BTRC CARD10 TAB3 IRAK2 TRAF6 IRAK4 MYD88 PMC6150077__F2 Diagrams of the Hedgehog, Wnt, Notch pathways and their roles for gemcitabine resistance SUFU APC SMO CTNNB1 GLI3 PMC5859839__F3 Pathway of ER-positive breast cancer target PPI network (blue circle stands for breast cancer gene; red diamond stands for pathway) EGF PIK3CA MYB EGFR PTGS2 MTOR PLK1 MYC YAP1 EIF4E IGF1 STAT5B NR3A2 PAK1 PPP2R2A BCL2 KDR SRC ELF5 SIRT1 CCND1 PMC5037530__F1 The gSkM transcriptome for the comparison of HFD-ED and HFD-corn oil fed mice COX7B NDUFB5 ACADM NDUFB10 SDHB PDHA1 DLAT SUCLA2 OGDH NDUFS6 HEL-S-5 NDUFB7 ACADVL NDUFB3 ACADL PPA2 HEL-S-26 CPT2 CPT1A SDHC PMC11005242__F7 GLUT3-mediated cigarette smoke-induced epithelial-mesenchymal transition in chronic obstructive pulmonary disease through the NF-kB/ZEB1 pathway PMC7348946__F3 Simplified overview of the CD28, PD-1, and TCR signaling pathways in T cells CD80 TBX21 LAG3 PMC11697715__F3 Histone lactylation changes in tumor-associated macrophages ARG1 TRAF6 PMC7348946__F2 Simplified overview of the TCR and CD28 signaling pathways in T cells CD80 LCK PMC7348946__F1 Simplified overview of NK cell activation by the NKG2D pathway ULBP3 ULBP1 VAV1 MICA GRB2 MICB ULBP2 PMC10983073__F3 Diagram of the inhibition of TSLP Signaling by HZ-1127 and TEZE STAT3 TSLP JAK1 PMC9433749__F1 Gearing up for battle: Harnessing adaptive T cell immunity against gram-negative pneumonia APC CXCL1 AREG PMC4282639__F6 Chronic exposure to TGFB1 regulates myeloid cell inflammatory response in an IRF7-dependent manner TGFB1 CXCL1 IRF7 CXCL2 TGFBR1 PMC4756317__F6 GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway WT1 GAL SSR2 PMC3657472__F1 Genetic predisposition to peripheral nerve neoplasia: Diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes CD44 RET PMC8408559__F5 Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer GATA2 STAT3 TXNIP EVI1 CCL2 FANCC TXN BCR PIM3 PAX5 PAX2 MAF NPM1 SP3 MDM2 PAX3 GAS7 HEL-S-133P PLG OLIG2 MCF2L ERG PAX6 FLI1 tal-1 TSC1 BRCA1 AXIN1 BCL2 CCL4 PLEKHG2 CCL22 STK11 LEP GAS RELB POU2AF1 LATS1 CREB3L2 LATS2 RHOBTB2 CLU LDLR CAV2 ETS2 PIM1 HEL-S-67p TEP1 SDC1 KRAS PAX1 IGF2 VHL CBL RUNX1 PDGFRA FGFR3 GATA4 RRAS2 PMC5762387__F5 MEF2 signaling and human diseases PLCG1 MEF2B EGFR PLCB3 MEF2C CTNNB1 MEF2D PMC4402595__F2 Relationship between the genes in each module from the GBM dataset RB1 MDM4 CYP27B1 PIK3CA CDKN2A QK3 EGFR PTEN CDKN2B MDM2 CDK4 PMC2756045__F2 LKB1-AMPK pathway: metabolism and growth control in tumor suppression TSC2 NR2A1 SNRK CRTC2 KSR1 HDAC5 MAP2 IRS1 PMC9160826__F1 Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma HMOX1 LOX GPX4 ASCL4 LPCAT3 PMC2756045__F4 LKB1-AMPK pathway: metabolism and growth control in tumor suppression CDC42 APC MAP2 CTNNB1 PMC2756045__F3 LKB1-AMPK pathway: metabolism and growth control in tumor suppression RHEB TSC2 EIF4B TSC1 NF1 PTEN IGF1R MTOR IRS1 EIF4E PMC2884012__F1 Tuberous Sclerosis Complex: A Brave New World? RHEB TSC2 TSC1 PTEN PMC11932036__F1 Notch Signaling Pathway Interfering as a Possible Asthma Treatment: A Narrative Review NOTCH2 NOTCH3 NOTCH1 PMC7714932__F4 Vascular diseases: the roles of miR-21/miR-21-3p in ECs and VSMCs TPM1 NR1C1 SP1 ADRA2B RHOB PTEN PMC3206195__F3 Fear Conditioning, Synaptic Plasticity, and the Amygdala: Implications for Posttraumatic Stress Disorder FRS2 BDNF PMC7714932__F3 Cardiac hypertrophy and HF: the roles of miR-21/miR-21-3p in CMs, CFs, and ECs GSK3B HDAC8 PTEN SPRY1 PMC9423097__F2 Interplay between Helicobacter pylori and the gut microbiota: An emerging driver influencing the immune system homeostasis and gastric carcinogenesis NLRP3 FOXP3 PMC4536758__F1 Idelalisib —targeting PI3KD in patients with B cell malignancies CXCL12 SYK CXCL13 BCR CCL3 CXCR5 CCL4 CXCR4 PMC4467301__F1 Epithelial–mesenchymal interactions mediated by Sonic Hedgehog pathway in embryonic lung FOXF1 GRINA COL18A1 PTCH1 SHH SIRPA ESM1 FLT1 SMO NOTCH2 PECAM1 IL1B PMC7465890__F10 Asp metabolism after enteral administration within the small intestine (a) and liver (b) and postulated metabolic pathway of Ala in periportal hepatocytes MAL CP CIT PMC7714932__F2 Ischemic heart disease: the roles of miR-21 in CMs and CFs.Reported major signals in CMs FAS SMAD2 MMP2 PTEN PMC4087218__F4 Resveratrol on protein phosphorylation in the insulin signaling pathway and the mTOR pathway of obese mice PTEN MTOR IRS1 EIF4E PMC10093079__F7 Baicalein inhibits cancer cell progression by targeting P13K/FOXO pathways BAX PTEN MTOR PMC4582667__F1 Phosphatidic acid: a new therapeutic lead to suppress hepatic glucose production LPA PC PMC2777795__F2 Negative-feedback loop linking NAD+/SIRT1 with the Clock network NAMPT SIRT1 PMC4519954__F14 Chemokine signaling pathway CRK ARHA GRB2 SHE DAO PMC10093079__F5 Baicalein in regulating the cancer signaling pathways ERF ATF2 MDM2 MTOR PMC9160826__F2 Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma IREB2 ZFP36 HCAR1 KEAP1 GPX4 FACL4 GABPB1 FTH1 CISD1 NQO1 PRDX5 MT1G CP PMC8273767__F5 Insights Into Transcriptome Profiles Associated With Wooden Breast Myopathy in Broilers Slaughtered at the Age of 6 or 7 Weeks CDC42 CRK BAD VASP FYN HEL-S-28 ARHA GRB2 SHE PMC3430547__F4 TORC1 and nitrogen regulation MKS1 MAF1 NPR2 NPRC PMC7432414__F6 Putative signaling pathway involved in HRPC–CAF transition mediated by PDGF-BB increase CXCL11 CCL18 PMC2172491__F1 The PI3K–Akt–TSC–TOR pathway and feedback regulation of insulin/IGF-I signaling BAD INS EIF4E PMC8302486__F3 Interferon B, an enhancer of the innate immune response against SARS-CoV-2 infection ISG20 STAT2 IRF9 IFITM3 OASL RNASEL JAK1 TYK2 PMC8684386__F3 Multifunctional Non-Coding RNAs Mediate Latent Infection and Recurrence of Herpes Simplex Viruses ATF3 CTCF MAP3K7IP1 RIGI SP1 LAT GC PMC9162456__F3 Natural and engineered metabolic pathways to biofuels TES IPP ADM AHR FAP ACR PMC4944541__F2 Crosstalk between leukemia cell and BM MSCs RELA MSC VCAM1 CCL2 PMC6692187__F1 IRE1A structure, activation and potential roles in cancer SPARC VEGFA XBP1 ID1 TRAF2 PMC9502172__F8 HSP27 Attenuates cGAS-Mediated IFNB Signaling through Ubiquitination of cGAS and Promotes PRV Infection TBK1 CGAS IRF3 PMC8234554__F2 An Updated Understanding of the Role of YAP in Driving Oncogenic Responses LATS1 LATS2 CRB3 AMOTL1 ARHA NLK CTNNB1 PMC8808072__F9 Polygenic networks in peripheral leukocytes indicate patterns associated with HIV infection and context-dependent effects of cannabis use DVL1 EGF PIK3CA BAD HGF APPL1 PIK3R3 PIK3CD AKT3 GSK3B PIK3R1 BRAF PTEN IGF1R MAPK9 MAPK8 MAPK3 PRKCB CTNNB1 VEGFB BCL2L1 PDPK1 PRKCA SRC MAPK1 ACTN1 JUN VEGFA KRAS SPP1 HRAS BCL2 RPS6KA3 MAP2K1 MAP2K2 PMC2695822__F10 Display of genes with high expression in CT embryos MTCH2 NTS PALLD GH1 PMC8306625__F4 PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases MAVS GLS IRF3 IRF7 TRAF3 DUOX2 PMC4001295__F7 Opposing TNFA/IL-1Beta- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation SMAD1 DKFZp781O1323 BMP2 RUNX2 IL1B PMC3270058__F9 Endothelial adaptive response to moderate hypothermia (25°C/72 h) TH HMGB1 PDIA4 NASP TPRX1 RRM1 HNRNPDL ZNF224 NAMPT IMPDH2 BANF1 L3MBTL2 ENO1 PMC7643190__F1 Biomarkers, molecular pathways, existing and emerging therapeutic targets in colorectal cancer EGF EGFR APC BRAF MTOR KRAS CTNNB1 PMC3065454__F8 Advanced Computational Biology Methods Identify Molecular Switches for Malignancy in an EGF Mouse Model of Liver Cancer STAT3 EGF STAT2 TRAF6 IGF2 IRS1 GATA3 FOXO4 INSR PAK1 ATF1 ADAM10 ATF4 NLK GRB2 JAK1 SRC PMC8421619__F1 Investigation of MDMA Inhibitory Effect on CytochromeP450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol CYP2B6 CYP3A4 PMC5901475__F2 Therapeutic approaches for Treg enrichment in vivo NR1i1 CCL22 IL33 CCR4 FOXP3 MTOR PMC6514096__F4 Interconnection of the pathways studied, the genes in which we have measured expression and connection to mitochondrial respiration UCP2 SIRT3 PINK1 MFN2 PTEN HIF1A MTOR SIRT1 EIF4E ADA PMC7224208__F8 Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues IFNG STAT1 UCP1 SREBF2 IRF3 IRF7 ATF4 MYC PMC11554266__F3 This illustration details the PI3K/AKT/mTORC1/HIF1A pathway, focusing on its regulatory role in glucose uptake through GLUT1 and GLUT4 transporters EGFR HIF1A PMC4066219__F2 IL-15: a central regulator of celiac disease immunopathology JAK3 FOXP3 PMC7438559__F12 Working model of the experimental validation BAX IGF1 MTOR ATG5 PMC11827889__F1 TrkA/NGF/NRP1/GIPC1 targeting for pain treatment NGF NRP1 PMC8144624__F5 Health monitoring in birds using bio-loggers and whole blood transcriptomics MAFK NLRX1 INTU ATG12 CHUK CXCL10 ATG5 CYLD PMC2713013__F3 MICROBE SENSING, POSITIVE FEEDBACK LOOPS, AND THE PATHOGENESIS OF INFLAMMATORY DISEASES TBK1 CD36 MAL TLR9 CD14 IRAK1 IRF3 IRF7 TRAF3 TNF TRAF6 MYD88 UNC93B1 TLR1 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC4141456__F1 Anti-microbial responses REL FADD MYD88 PMC316759__F5 Regulation of reproductive growth and metabolism by the DAF-2 insulin receptor-like signaling pathway IGF1 PI3 PDK2 PMC2713013__F7 MICROBE SENSING, POSITIVE FEEDBACK LOOPS, AND THE PATHOGENESIS OF INFLAMMATORY DISEASES IRAK1 TRAF6 IRAK4 IL1B MYD88 PMC8234554__F3 An Updated Understanding of the Role of YAP in Driving Oncogenic Responses ELMO3 CSF2 CSF1 AXL HK2 CXCL5 AREG IL6 ARHA MYC CCL2 MED1 CSF3 ARHGAP29 PIG59 COX2 CDK9 LPAR3 PMC8108028__F1 BRCA mutated pancreatic cancer: A change is coming RAD51 BRCA1 BRCA2 ATM PALB2 PMC10451182__F2 Intrinsic and extrinsic apoptotic pathways and confirmed target genes of miR-106a BAX FAS FAF1 PTEN TNF FADD PMC6505570__F1 Myxoid liposarcoma: it's a hippo's world LATS1 FOXM1 LATS2 PLK1 YAP1 PMC3469622__F1 Quantitative Phosphoproteomics Reveals SLP-76 Dependent Regulation of PAG and Src Family Kinases in T Cells JUN BCL10 CSK ITK GRB2 REL FOS LCK PMC3889810__F6 Whole genome and gene set enrichment analysis of cells expressing mutants of neuroserpin show an upregulation of the cholesterol pathway when polymers are expressed HMGCS1 CYP51A1 HMGCR SQLE PMVK MVD SREBF2 DHCR7 FDPS IDI1 FDFT1 MVK PMC8120202__F5 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS BRD4 HMGB1 TSHR RASGRP3 SMAD2 LRP5 SMAD6 SMAD4 LRP6 PTEN TERT NOX4 CTNNB1 FOXP3 NACA PMC8120202__F4 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS ARF4 PTEN SRC CD63 VCP PIGU PMC4399414__F11 Hm-MyD88 and Hm-SARM: Two key regulators of the neuroimmune system and neural repair in the medicinal leech UBE2D2 TRAF6 LBP IRAK4 PMC8120202__F3 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS HMGB1 FOS PMC8120202__F2 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS CSA2 SMAD2 LRP5 SMAD4 LRP6 FOXP3 NOX4 CTNNB1 PMC6070887__F2 Metabolic rewiring following T cell activation IFNG IL10 FAS IL6 FOXP3 MTOR PMC5400530__F1 Lipid and Alzheimer’s disease genes associated with healthy aging and longevity in healthy oldest-old PPARG APOC1 TGFB1 APC APOE LPA HEL30 MTTP KHDRBS2 APOB APP HFE HP PMC3782519__F1 MicroRNAs as novel immunotherapeutics MAPK1 STAT3 EGF SHC1 EGFR TYK2 MAPK3 PMC3342562__F6 Schematic representation of the role of H2S in atherosclerosis VCAM1 CCND1 PMC8042400__F2 Biosynthesis of VLC-PUFA and VLC-SFA ELOVL4 ELOVL3 ELOVL2 ELOVL1 ELOVL5 PMC6710239__F1 Before binding by a Hedgehog family ligand (most often Shh, but also Ihh or Dhh), Ptch1 and presumably Ptch2 maintain Smo sequestered, by a currently unknown mechanism GPR161 CDON BOC SUFU SMO GAS1 IFT172 GLI3 PMC9047687__F7 Whole Transcriptome Profiling of the Effects of Cadmium on the Liver of the Xiangxi Yellow Heifer LPL TSC2 UBC FAS POC1A CD36 F2 UCP1 HEL-S-28 PLTP SHE ACP7 PMC3191732__F1 Cyclooxygenase pathway of AA metabolism LTA COX1 COCH PMC9935926__F7 Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions PGP OLFM4 TGFA EGFR BNIP3 PMC9371632__F2 Innate Immune Response and Inflammasome Activation During SARS-CoV-2 Infection TBK1 CGAS MAVS IRF9 IRF3 IRF7 IL6 TRAF3 TRAF6 MYD88 TLR3 TLR7 TRAF2 TYK2 ACE2 PMC4831116__F1 An overview of plant hormone signaling networks and their crosstalk in stress responses MYB ERF MYC PMC7506139__F3 BCAAs and fatty acids regulating inflammatory signals FAS NLRP3 IL1B PMC9935926__F3 Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions STAT3 PTEN MTOR SSB CTNNB1 PMC5724014__F6 Mechanisms of cytokine-induced dysfunction and death of insulin-secreting cells mediated by intracellular S1P IFNG PHB2 BAD PMC9140571__F9 Capturing Genetic Diversity and Selection Signatures of the Endangered Kosovar Balusha Sheep Breed CD48 CBL FYN BCL10 LAT ITK CTLA4 GRB2 LCK CDK4 PMC5609576__F1 Cross-talk between adipocytes, macrophages, and cancer cells modulating the tumor microenvironment CXCL1 IL33 CCL4 CXCL2 CCL5 CCL2 TNF IL1B PMC7352181__F4 Angiotensin-associated immunoinflammatory pathways in lung tumor microenvironment ACE2 PMC7352181__F3 Angiotensin-associated pathways involved on hypoxia and angiogenesis in lung tumor microenvironment EGF TGFA MTOR ACE2 PMC7352181__F2 Angiotensin-associated pathways associated with cell proliferation, invasion, and migration in lung tumor microenvironment STAR ACE2 PMC11635172__F3 Molecular mechanisms of the immune response are involved in the progression of ALD TLR4 CXCL1 LCN2 CXCL8 IL1B PMC5991421__F1 Computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention C6 CD59 FH C7 HEL-S-62p CR1 PMC7352181__F1 Renin-angiotensin system, its interaction with tumor hypoxia and angiogenesis and subsequent functional impact on tumor phenotype HEL-S-130P ACE2 PMC11635172__F2 Related pathway mechanism of pyroptosis, necroptosis, and ferroptosis in the occurrence and development of ALD RIPK3 SLC3A2 GSDMD NLRP3 TXNIP MLKL GPX4 FNDC3B RIPK1 SLC7A11 PMC5985737__F3 Relation of the studied NAFLD risk alleles to the main pathways in hepatic triglyceride partitioning TG PNPLA3 TM6SF2 GCKR HEL-S-70p LYPLAL1 PMC5072284__F6 Activation of phenylpropanoid-biosynthesis pathway in response to cold storage FH CAD CS SKI PMC8955828__F1 Autophagy Pathways in the Genesis of Plasmodium-Derived Microvesicles: A Double-Edged Sword? NBR1 ATG5 PMC4918128__F7 Networks of candidate cancer genes predicted by MUFFINN and their direct neighbors on HumanNet WNK1 AEBP1 SUZ12 EED PRPF8 KALRN FLT4 NF1 CSNK2A1 MMP2 NRAS FBLN2 CSF1R HNRNPL ROS1 CACNA1A FBN1 CACNA1C TRIO VCAN RANBP2 CHD4 MYOM1 DDB1 DLG2 BCOR PTK6 MYO3A TEX10 PTEN CTNNB1 VPS33B TTN SULF1 CDK4 VWF SPEN PA2G4 THBS1 LRRK2 MTA2 EPHB1 KRAS LRPPRC VHL MKI67 KATNA1 ALG6 PDGFRA EP300 PMC8616391__F1 Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It CD44 HAMP PMC3859141__F2 Molecular Pathways: Sterols and receptor signaling in cancer EBP EGFR LDLR SMO DHCR7 ABCA1 PMC8616391__F2 Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It HMOX1 SLC3A2 FTL STEAP3 GPX4 LPCAT3 FACL4 MT1G SLC7A11 HEL-S-64p PMC3859141__F1 Molecular Pathways: Sterols and receptor signaling in cancer EGFR LDLR MTOR PMC3500863__F3 Pathways regulating NEKs in cell cycle control CDC2 ATR NEK6 RAF1 NEK11 NEK2 ATM NEK9 PLK1 PMC3796213__F2 Connectivity map of NRF2-mediated oxidative stress response adapted from IPA software HEL-S-107 CRAT KEAP1 GCLM GSK3B MAF HEL-75 UBB PMC3947043__F1 Molecular alterations and biomarkers in colorectal cancer TGFBR2 PIK3CA CACNA1G APC NEUROG1 BRAF SOCS2 PTEN KRAS IGF2 CTNNB1 RUNX3 PMC2695927__F4 Bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease OMP BPI CD14 LBP PMC4118485__F7 Simplified schematic showing the proposed mechanism of how SEs may suppress cellular immunity and antitumor responses STAT3 JAK3 PMC7583816__F1 Diagram of proposed Pi-induced PP2A/Src/DAPK-1/TPM-3 signaling pathway TPM3 SRC PMC12186155__F1 Proposed mechanism of schaftoside anti-inflammation effects through the NFKB signaling pathway in LPS-induced inflammation on RAW 264 COX2 TLR4 IL6 PMC8784222__F2 COVID-19-diabetes mellitus molecular tetrahedron LPA CD36 MAK TLR4 HEL-S-5 DPP4 GIP IL6 MTOR ACE2 PMC9652018__F1 Growing Role of the BH3 Mimetic Drug Venetoclax in the Therapy of Acute Myeloid Leukemia BAX BAD BMF BIK PMC8784222__F3 COVID-19-diabetes mellitus molecular tetrahedron UCP2 UCP1 ACE2 PMC4415581__F7 TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway CDK5 ATM TIGAR PMC8733431__F7 NETME: on-the-fly knowledge network construction from biomedical literature STAT3 EGF PIK3CA MMP14 CSF1 TGFB1 PCNA PGR EGFR SLC2A4RG RHO SETD2 MYC IRAK4 MAPK3 CAMLG HMOX1 ADAM17 IL18 SP3 MMP2 ABCG2 SRC MCTS1 MAPK1 S100A4 DOCK8 SP1 ANXA2 PLG SLC16A4 AREG MMP9 VEGFA IL6 hEMMPRIN RAC1 CD44 IGF1 NFKB1 HEL-S-69p TNFSF11 WASF1 PMC5763493__F3 Deubiquitylation and regulation of the immune response SYK BCL10 BCR LYN CYLD TRAF2 PMC3783933__F1 IIS/TOR signaling pathway in fat body and the central nervous system of Drosophila RHEB TSC2 TSC1 ALK PTEN PMC10741038__F5 PC biosynthesis in S PGP PSD PC PMC3845553__F1 IGF-1R as an anti-cancer target—trials and tribulations IGF2R IGF1 PTEN IGF1R MTOR IGF2 PMC6407710__F7 Comparison of the phosphoketolase engineered pathway with oxidative pentose phosphate pathway RPE PPIE ME2 APC CS POLE CIT PMC10218067__F7 Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo CCNE1 CDK2 BCL2 MTOR PMC4972110__F1 Oncogenic addiction versus synthetic lethality to explain GSK621-induced cytotoxicity in AML RHEB MTOR EIF2A PMC8616208__F2 Metabolic Control of Myeloid Cells in the Tumor Microenvironment ACLY STAT3 TG KEAP1 COX2 CD36 AHR ARG1 PMC3800594__F2 Schematic model of novel cytoprotective mechanisms in response to oxidative stress in Beta-thalassemic (Beta-thal) erythroid precursors HEL-S-2a ATF4 EIF2A PMC7960990__F6 Importance of cellular and exosomal miRNAs in mesenchymal stem cell osteoblastic differentiation TH tmp_locus_29 EME1 CIT PMC2936065__F2 The Lrp5-dependent regulation of bone formation through inhibition of tph1 expression and 5-HT synthesis in enterochromaffin cells TPH1 HTR1B LRP5 PMC8534848__F2 Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment SPN TGFB1 IDO1 RELB AHR SOCS3 SRC PMC3545869__F7 Integration of Canonical and Noncanonical Wnt Signaling Pathways Patterns the Neuroectoderm Along the Anterior–Posterior Axis of Sea Urchin Embryos DKK1 WNT1 CTNNB1 PMC4551213__F6 A force-sensitive signaling network involving TRPC6 and TRPM4 channels in cerebral artery smooth muscle cells PLCG1 TRPC6 SRC PMC6443256__F1 DNA sensors and related signaling pathway TBK1 CGAS MAVS TLR9 AIM2 IRF3 IFI16 IRF7 MYD88 MRE11A DHX36 IL18 DDX41 IL1B PMC8843930__F1 Toward a Better Classification System for NK-LGL Disorders STAT3 TET2 FAS MTOR MYC CCL2 IL6R PMC11003173__F5 Metabolic pathways of glutathione and expression profile of related genes OPLAH HEL-S-64p HEL-75 PMC5538798__F10 Schematic diagram summarized as a possible mechanism of action of melamine causing tubular cell injury via CSR-mediated Ca2+signaling pathway BAX TGFB1 ME1 PMC12214129__F8 The effect of miR-1 loss on glycolytic and pentose phosphate enzymes and intermediates SLC16A3 PDK4 PTBP1 H6PD HEL-S-162eP ENO1 HEL-S-87p PMC4852795__F1 Mechanistic target of rapamycin (mTOR) signaling pathway RHEB TSC2 GRB10 TSC1 INSR ULK1 TFEB DEPTOR IRS1 PMC6468398__F1 Biogenesis and function of ribosomal RNA-derived fragments TIMP3 AGO1 AGO2 PMC8688140__F1 Mechanisms of action of ivermectin against SARS-CoV-2—an extensive review STAT3 PLG KPNA1 PMC9706722__F3 Genomic characterization of intracranial teratomas using whole genome sequencing MAX FLT3 PIK3CA STK11 BRCA2 PTEN MTOR AMER1 MYC DCHS1 TEAD4 TGFBR1 MGA PORCN NCOR1 NF1 FGFR1 CHEK2 JAG2 ATM MXD1 MXD4 PPP2R1A TCF7L1 PCDHJ KRAS SFRP1 ARAF RICTOR PSEN2 NTRK1 FGFR3 RPS6KA3 FAT2 PMC4937164__F1 Bile acid metabolism in the liver FGF8A CYP7A1 FGFR4 LDLR DKFZp666G145 PMC11670419__F2 BA regulates glucose homeostasis FGF8A UCP3 FABP1 FGFR4 UCP1 PMC11670419__F1 Primary bile acid metabolism and secondary bile acid metabolism pathways with microbially encoded enzymes CYP7A1 GCA CYP27A1 PMC7826847__F3 C-CAMs involvement in radial migration during neocortical development CDH2 CRK DAB1 NECTIN3 NECTIN1 VLDLR GC CRKL CDH4 SRC CTNNB1 CP PMC5807065__F4 Insulin signaling and type 1 diabetes mellitus pathways SOCS1 FOXO1 RS1 SOCS2 IL2 SOCS3 TNF IRS1 PMC11911305__F2 Simplified unscaled representation of MD‐2/TLR4 complex signaling induced by extracellular LPS TBK1 MAP3K7IP1 TIRAP TLR4 CD14 IRAK2 IRF7 TRAF3 TRAF6 LBP IRAK4 MYD88 PMC3181488__F2 Signal-receiving cell—modulation of developmental signalling by intracellular trafficking CBL EGFR KIF16B LRP5 LRP6 SMO PMC5465008__F2 Crosstalk between leptin signaling, cancer stem cells, histone deacetylases and microRNA HDAC3 EPCAM CD24 LEP LEPR HDAC7 HDAC11 HDAC6 PMC4271569__F8 The most sensitive regulations CNTF NGF GFAP MOG ChAT NEFH PMC5249073__F4 First Insights into the Subterranean Crustacean Bathynellacea Transcriptome: Transcriptionally Reduced Opsin Repertoire and Evidence of Conserved Homeostasis Regulatory Mechanisms CD40 TIRAP IRF9 CTSK TLR9 CD14 CPO IRF3 IRF7 MTOR TRAF3 TRAF6 IRAK4 RAC1 GFAP TLR3 TLR4 PDC LBP CD6 FADD PMC5530465__F1 Metabolism of chemotherapeutic drugs-related gene polymorphisms RFC1 GSTM1 PMC6328967__F4 Interaction between Wnt/Beta-catenin signaling pathway and HCV core protein APC LRP5 LRP6 PMC3876077__F1 Schematic overview of the transforming growth factor (TGF)B signaling pathway SMAD4 SKI PMC5991907__F4 PARP1 regulates repair of oxidative DNA damages OGG1 LIG1 FEN1 PCNA BRCA1 PARP1 PMC3047755__F7 Proposed model for how Shh signaling pathway negatively regulates its mitogenic potential through Beta-arrestin 1 SHH SMO IRS1 PMC5991907__F3 PARP1 contributes to regulation of redox-related signaling pathways TF BAD SGK1 MAP2K6 MCL1 IKBKB NGFR PIK3R1 MTOR RAC1 MYD88 PMC5567665__F1 Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2 sensing and hyphal development in Candida albicans HEL60 ACO2 HEL-S-32 MDH2 HEL-S-26 PMC4647060__F2 Schematic of CLCA1-driven MCM in human airways based on the current literature CLCA1 MAPK13 PMC3200456__F1 Toxoplasma gondii effectors are master regulators of the inflammatory response IFNG IL1B PMC11088914__F3 The interaction of the lipid pathway with other signaling pathways for the regulation of pluripotency SMAD1 DKFZp781O1323 FRS2 SMAD2 APC SOX2 SMAD4 NODAL MYC IGF2 FGF2 CTNNB1 TCF3 PKD1 BMP4 TBX3 GRB2 PMC3634439__F3 StarD7 in various cellular events in JEG-3 cells STARD7 PC ABCG2 CTNNB1 PMC3625859__F3 Regulation of angiogenesis by microRNAs (miRNAs) HGS SPRED1 SUFU MYC PMC2996236__F5 Pathogenesis of the complement-mediated autoinflammatory disease atypical hemolytic uremic syndrome CFI PMC7569567__F8 Kinase inhibition in autoimmunity and inflammation LTB CD40 BCR RELA RELB TRAF3 TRAF2 PMC10537735__F10 Modified Curcuminoid-Rich Extract Liposomal CRE-SDInhibits Osteoclastogenesis via the Canonical NFKB Signaling Pathway CTSK NFATC1 PMC11961428__F4 Proposed inflammatory mechanisms hypothesized to underlie HACE AQP4 GDNF NLRP3 PMC6031075__F1 Putative model of the functions of HSPGs in CRC cells SYN2 CTNNB1 PMC7813945__F4 JAs biosynthetic pathway and JAs signal transduction network LOX PMC10744266__F1 Action of warfarin relevant to pharmacogene identification (further details provided in the Data Supplement) CALU CYP2A6 GGCX APOE CYP1A1 ORM2 VKORC1 VIT EPHX1 NQO1 CYP2C9 CYP4F2 CYP3A4 ABCB1 PMC10910842__F2 Roles of the kinesin-2, 3, 4 family members in HCC KIF3B KIF1B PMC4611285__F1 AKT and ERK signaling pathway STAT1 BAD MDM2 PMC11961428__F2 Transcriptional regulation of HIF induced by hypoxia, adapted from (3) EPO BNIP3L VHL PMC8612621__F3 Crosstalk Between Parkinson's Disease and Energy Metabolism UCP2 BAX BCL2 KIN PMC2996236__F2 Autoinflammatory disease regulated by IL-1B (inflammasomopathies) and NFKB NLRP12 NLRP7 NLRP3 IL16 PSTPIP1 IL1B PMC7906938__F2 Immunological Mechanisms Underlying Sterile Inflammation in the Pathogenesis of Atherosclerosis: Potential Sites for Intervention HMGB1 NLRP3 CD36 TLR4 IRAK1 S100A12 KRAS IL1B MYD88 PMC4659514__F1 Proteins implicated in Parkinson’s disease (PD) maintain a healthy pool of mitochondria PINK1 LRRK2 PMC11722372__F2 The putative biosynthetic pathway of DAs in Aconitum plants IPP MVP MVD MVK PMC10875894__F8 VNP-shCCDC25 blocking CCDC25-NET-DNA and remodeling immunity in B16F10-bearing mice and 4T1-bearing mice CDC42 CD80 PARVB HEL-S-28 CCDC25 MIP RAC1 PMC10910842__F3 Roles of the kinesin-5, 6 family members in HCC FOXM1 KIF11 KIF20A PAK6 LIN9 CTNNB1 KIF23 PMC7049408__F1 AMPK signaling pathway: schematic model depicts the main upstream regulators and downstream effectors of AMPK EEF2K EEF2 PMC10910842__F5 Roles of the kinesin-12, 13, 14 family members in HCC KIF15 STAT3 KIFC3 TSC2 TSC1 PHGDH KIFC1 MMP2 TBC1D7 TCF4 TWIST1 CTNNB1 PMC7197434__F2 Pharmacologic Approaches for Adapting Proteostasis in the Secretory Pathway to Ameliorate Protein Conformational Diseases ELF2 ATF4 XBP1 PMC2887678__F1 Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells ALG8 DPM2 ALG11 ALG6 ALG10 ALG2 ALG13 ALG3 PMC5788151__F6 Illustrating diagram for several growth factors and signaling molecules that regulate different stages of satellite cells HGF MYF5 PAX7 PMC10486640__F8 Identification of the expression of key genes of the TLR signaling pathway CD40 CD80 TIRAP CTSK TLR9 CD14 TLR5 IRF3 IRF7 MYC TRAF6 MYD88 TLR3 STAC TLR4 F10 TLR7 LBP FADD PMC7923093__F5 Regulatory pathway of differently expressed miRNAs TMEM30A EBF2 HORMAD2 TGOLN2 LRRC18 WIPF1 PPP1R2 IGFBP4 XKRX TMEM178A GHRHR GRID2 NAA11 PRSS54 SLC22A5 RGS7 MEX3C TRPV5 CREBL2 CYP7A1 DHX15 OTUD5 MKRN2 SRGN MLPH ABCE1 RNF185 MRPL40 NDRG3 CHRNA7 HEL-S-298 CLIC3 ACTR3 VAPB HEL-S-125m POLE3 RAP1A CASP3 CACNB4 SAA4 XYLB PMC8836259__F10 Oncogenic Mutation BRAF V600E Changes Phenotypic Behavior of THLE-2 Liver Cells through Alteration of Gene Expression TNLG1B ASL MMP10 CXCL1 IFIT1 IL33 RSAD2 MMP9 CCL5 LGALS9 CXCL10 GBP4 CXCL11 IL18 MMP3 ISG15 TNFSF10 IL1B PMC5787431__F2 KSHV LANA upregulates the expression of epidermal growth factor like domain 7 to promote angiogenesis KLF4 EGF RIMS1 MYO16 CLEC11A SIX4 TEX15 RHO HYDIN CDKL3 SKOR2 SDK1 CFAP54 DLX1 DPYSL4 RBP3 CAMK4 DMD ZNF521 EGFL7 RLN1 NHLH2 SOX17 P2RX7 SERPINC1 GPC1 GPR65 PCDH15 IL12A P2RX2 PAX6 DOCK1 CRHR1 HOXB4 LILRB2 KIF6 GRK1 ADAMTS2 PMC7663396__F1 Signaling pathways leading to signal transducer and activator of transcription 3 (STAT3) activation EGFR MTOR JAK1 SRC PMC9572668__F3 Molecular Mechanisms and Health Benefits of Ghrelin: A Narrative Review GHSR NLRP3 TLR4 IL1B PMC7569567__F2 Kinase inhibition in autoimmunity and inflammation STAT3 IL19 OSM STAT2 LIF JAK3 EPO IFNG STAT1 TSLP IL24 TPO STAT4 TYK2 PMC6625878__F1 Schematic figure summarizing the HIF pathway and the transcriptional regulation by HIF of genes related to angiogenesis, metabolism, survival/proliferation, metastasis, stemness, and the ECM TGFA ADM HEL-S-133P EPO FGF5C VEGFA HEL-S-30 IGF2 VHL CD44 ANGPT1 HEL-S-68p CCNG2 PFKL ABCG2 CXCR4 NOTCH1 PMC2921023__F7 Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin MTOR SRC GAB2 PMC7234907__F1 MET receptor tyrosine kinase engages intracellular molecular signaling pathways and controls neuronal morphological development CDC42 HGF LIMK1 MTOR RAC1 HTT PMC3193404__F1 NFKB signaling pathways initiated by TLR4, TCR, TNF receptor 1, CD40 and genotoxic stress CD40 TLR4 ATM CRIPT TRAF2 PMC10608541__F13 Pathways and localization of astaxanthin biosynthesis and esterification in Haematococcus algae IPP FAS DGAT1 DGAT2 PMC9651967__F7 Integrated proteomics and phosphoproteomics revealed druggable kinases in neoadjuvant chemotherapy resistant tongue cancer CDC42 MAPK1 KRT1 KRT10 SGK1 TRIP10 RASGRF2 PRKCZ STK24 PKP3 ARHA KTN1 RAC1 DOCK2 MAPK3 PRKCE ARHGEF12 PAK1 FOXO3A MAPK7 EIF5B MYO9B PMC7501262__F4 NLRP3 inflammasome in endothelial dysfunction IL1R1 HMGB1 NLRP3 IRAK1 VCAM1 TRAF6 IRAK4 IL1B MYD88 PMC3772111__F4 Computational models of the JAK1/2-STAT1 signaling SOCS1 STAT1 IRF1 PMC6204425__F3 Some regulator genes in the eu-/pheomelanin synthesis metabolism TF SLC45A2 PAX3 ASIP OCA2 POMC KL DCT KIT PMC4024346__F1 The ERK1/2 MAPK signaling network controlled by receptor tyrosine kinases and Ras BAD RAF1 MAP3K1 JUNB GRB2 FOS HDAC6 PMC11594976__F7 Differential expression of hormone signaling pathway genes in PhARF5- and PhARF19a-silenced petunias TF BIN2 EBF2 BAK1 PMC6831866__F20 Continuation of the processes described in A BAX CASP9 LPO CASP3 PMC7501262__F5 NLRP3 inflammasome in endothelial dysfunction NLRP3 PMC11055549__F3 Construction of the prognostic target-ingredient network CDC2 HEL107 AURKA KIF11 PPP1CC ATP1A1 CCNA2 PLK1 CCNE2 PNP TK1 PRKDC AURKB TTK CCNB1 CA9 CDK4 PMC11760113__F1 Metabolism of glutamine between normal cells and cancer cells GLUD1 GOT2 SLC25A18 GPT2 SLC38A1 SLC7A11 SLC7A5 GLS2 PMC2738707__F1 Regulatory pathways in hepcidin expression STAT3 EBP USF2 USF1 HAMP TMPRSS6 HFE2 PMC4196943__F5 Dissecting the Transcriptional Response to Elicitors in Vitis vinifera Cells VIT CS STS PMC7489940__F5 PI3K-AKT signing pathway MYB SYK PIK3CA BAD CREB3 DDIT4 GSK3B CRTC2 PTEN MTOR MYC CSF3 CSF3R YWHAQ PHLPP2 PRKCA CHUK PKN3 MDM2 RPTOR RPS6 CASP9 EIF4B TNFSF6 RBL2 CD19 STS EIF4E HRAS RHEB TSC2 FOXO3A RXRA CDK2 BCL2 CDC37 GRB2 PMC7363530__F1 Genetic pathways in nonalcoholic fatty liver disease (NAFLD) TG PNPLA3 MTTP TM6SF2 HSD17B13 ABHD5 APOB GCKR PMC6627586__F1 Scheme of copper and silver distribution in a mammalian cell ATOX1 SLC25A3 ATP7B COX17 HEL-S-44 ATP7A PMC6565468__F1 Convergence of Developmental Origins and Oncogenic Pathways in Malignant Brain Tumors CDC2 TET2 EGF HGF TET1 EGFR APC OLIG2 MTOR CDK6 NF1 PC CDK2 MDM2 HEL-S-26 CDK4 PMC6558092__F1 PD-1 signaling pathway in T cells.When engaged with a ligand, PD-1 becomes phosphorylated at its cytoplasmic tyrosine residue, leading to binding of protein tyrosine phosphatases (PTPs), such as SHP2 ZAP70 BATF LCK PMC9482157__F9 VEGFA promotes the occurrence of PLA2R-associated idiopathic membranous nephropathy by angiogenesis via the PI3K/AKT signalling pathway SCD DDIT3 PML ANAPC2 VEGFA BCL2L11 PMC3087179__F5 IL-4R Drives Dedifferentiation, Mitogenesis and Metastasis in Rhabdomyosarcoma IL13RA1 IL13RA2 PMC3851989__F2 The second module identified by iMCMC and the corresponding known pathway in the GBM data TSPAN31 CDKN2B CDK4 PMC4899284__F1 Folate-Mediated One-Carbon Metabolism MTHFD2 MTHFD1 DHFR SHMT1 MTHFD2L TYMS HEL-S-51e PMC2943518__F7 Diagram of a putative LPS-induced PTP/LITAF/TNF signaling pathway LITAF TLR4 PTP4A3 PMC4765525__F1 Wnt signaling pathway from KEGG POR BAMBI RBX1 SOST ROCK2 APC GSK3B SMAD4 SKP1 HEL-S-11 WIF1 PMC5375627__F5C Induction of glycolytic and tricarboxylic acid cycle enzymes by M-CSF and GM-CSF ENO2 HK3 IDH3B PFKFB2 CS MDH2 PFKFB4 ACO2 HEL-S-133P HK2 SDHD SDHB DLAT PDHA1 ENO3 HEL-S-68p OGDH PFKP HEL-S-49 SUCLG2 DLD ENO1 PFKL HEL-S-87p SDHC PMC6328967__F5 Interaction between COX-2 signaling pathway and HCV core protein NOX4 PMC7730176__F3 Estrogen and anti-estrogen signaling in glioblastoma TF STAT3 MTOR PMC11849288__F4 Expression profiles of genes in starch and sucrose metabolism pathway MYB FRK FOS STS PMC3323875__F3 Feedback inhibition mediated by the PI3K/AKT/mTOR pathway ERBB3 RHEB TSC2 GRB10 TSC1 IGF1R GRB2 INS IRS1 PMC4967146__F1 Regulation of mRNA translation initiation by the mechanistic target of rapamycin complex 1(mTORC1) signaling pathway RHEB RPS6 TSC2 TSC1 IGF1 ELF2 EIF4E PMC6678402__F2 Illustration of proposed mechanisms of stem cell therapy in rescuing ischemia-reperfusion induced acute kidney injury TEC FAS MAF ELL TNF PMC4899284__F2 The de novo thymidylate synthesis pathway as a nuclear multienzyme complex at sites of DNA replication MTHFD1 DHFR TYMS PMC7108857__F10 Working model of FMDV 3A regulation of the G3BP1-mediated RLH signaling pathway TBK1 LRRC25 IRF3 TRAF6 PMC9450830__F4 Human arginase 1, a Jack of all trades? ASS1 IGF1 PMC9981633__F1 Targeting matrix metalloproteases in diabetic wound healing CXCL9 CXCL12 CD80 CXCL16 CXCL10 NOTCH1 PMC11274428__F1 The PI3K/Akt/mTOR Axis in Head and Neck Squamous Cell Carcinoma MLST8 TSC2 TSC1 PTEN HIF1A MDM2 MTOR DEPTOR PMC3466369__F1 Emerging Roles for Cholesterol and Lipoproteins in Lung Disease ABCG1 TLR4 LDLR ABCA1 PMC6715851__F2 Differences in the carbon flux distribution in oleaginous rhodococci under nitrogen-rich and nitrogen-poor (TAG accumulation) conditions CRP FAS NONO PMC7603577__F11 AGE-RAGE signaling pathway in diabetic complications in the treatment of gout and hyperuricemia with plantain BAX IL6 PMC7603577__F10 TNF signaling pathway in the treatment of gout and hyperuricemia with plantain LTA MAP3K7IP1 TRADD TAB3 TRAF5 IL6 MMP9 TNF TRAF2 FADD PMC3322159__F8 JC Virus T-Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells HK2 CCNB1 PMC3713637__F4 Transcriptional regulation network centered on SP1 involves many genes of interest from pathways enriched in memory impairment SP1 APOE ACTN2 RAC1 MAPK3 FYN ITGB1 PLCB1 CALM1 PLCB2 CAMK4 PLCB3 CREB1 PMC6137035__F7 Pathway schematic STAT3 HIF1A CA9 VHL PMC11670419__F3 FXR signaling in diabetic nephropathy TG FAS DNM3 CPT1A CTNNB1 PMC6114234__F1 Synthesis, metabolism and anticancer mechanism of vitamin D NR1i1 CYP27B1 DBP CYP24A1 COX1 HEL-S-11 MTOR CYP27A1 CTNNB1 PMC7430807__F2 Metabocentric view of cardiac remodeling CITED4 MTOR CEBPB PMC1800873__F1 Progression pathway network with w = 0.8, E = 0.8 and the LH algorithm CDKN2A GPC3 PMC7565554__F4 mTORC1 inhibits various steps of autophagy ATG101 ULK1 UVRAG TFEB NRBF2 AMBRA1 ATG14 PMC5374322__F3 Relationships among miRNAs and canonical Wnt signaling, metastasis, and tumor-initiating cells TCF7L2 IGF2BP1 HMGA2 GSK3B LRP5 NUMB LRP6 ASCL2 GPR49 CTNNB1 PMC5374322__F2 Genes frequently mutated in colorectal cancer and their relationships with miRNAs TGFBR2 LIN28B SMAD4 PTEN MYC KRAS CTNNB1 PMC7565554__F2 Transcription factors downstream of TORC1, input linked to their action and cellular processes affected MLST8 TFEB ATF4 MTOR DEPTOR PMC5374322__F1 Step-wise tumorigenesis in colorectal cancer TGFBR2 PIK3CA APC BRAF SMAD4 PTEN KRAS CTNNB1 PMC3565105__F1 Hypothetical model illustrates the E2-ERA signaling pathway involving both genomic and extranuclear signaling pathways PELP1 POLL GSK3B POLI SRC PMC7565554__F1 TORC1 and TORC2 subunits and processes controlled by the complexes PRR5 MLST8 RICTOR MTOR DEPTOR PMC4831796__F7 Inhibition of Phosphatase Activity Follows Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor MITF GPNMB PMC3233666__F1 Adaptation of endothelial cells to inflammatory stimuli and hypoxia TLR4 RELB HIF1A VCAM1 TRAF3 CXCR4 VHL PMC8006752__F1 BAP1 nuclear and cytoplasmic physiologic activities OGT RAD51 FOXK1 BAP1 INO80 ASXL1 SLC7A11 ASXL2 BARD1 ASXL3 BRCA1 MCU FOXK2 PMC9023792__F1 Emerging Role of Hedgehog Signaling in Viral Infections ADRBK1 EVC2 SUFU PTCH1 BCL2 SMO MYC GLI3 PMC10864729__F6 Predicted downstream pathway of MIR17HG IPO11 ITGA1 MDM2 PMC9023792__F2 Emerging Role of Hedgehog Signaling in Viral Infections EVC PTCH1 SMO GLI3 PMC8014416__F6 KEGG pathway analysis on three up-regulated DEGs THSD4 SMAD4 RBL2 PTEN RGMB CD19 MTOR TNF RAC1 IFNG BCR RXRA SKP1 PMC6205963__F1 Fibroblast of Growth Factor (FGF) signaling activation and regulation FGF12 FGF22 FRS2 FGF14 FGF21 FGF7B FGF6B FGF5C FGF10 FGF2 FGF8 FGF7 FGF7A c-fgr SH3BP4 SHH FGF20 GRB2 GAB2 FGF18 HES1 FGF23 PMC2780838__F1 The complement cascade MASP1 C6 C7 HEL-S-62p C2 C1S C9 C4A C4B_2 CR1 PMC7658718__F7 Schematic model illustatrating the redox regulation of PD-L1 expression through growth factor signaling EGF EGFR FGFR1 PMC3536347__F2 Pharamcologic activators and enhancers of the Wnt/Beta-catenin signaling pathway and known interactions with pathway components (see for references) SOST DKK1 APC LRP5 LRP6 PMC3536347__F1 Pharmacologic inhibitors of the Wnt/Beta-catenin signaling pathway and known interactions with pathway components (see for references) SFRP4 FZD8 TNKS APC GSK3B FZD7 LRP5 LRP6 CTNNB1 PMC6445295__F1 Analysis of human inner ear transcriptome over-layed on a generic human neurotrophin signaling pathway GRB2 PMC2819352__F6 Relationship of GPAT4 to other enzymes in the pathway of de novo glycerolipid synthesis LPA HMFN0839 GPAT4 GPAT2 PC PMC6595574__F2 Signaling pathway and inhibitors of inflammasomes NLRP3 IL1B BRCC3 PMC5378756__F1 The activation, amplification and regulation of the complement system FH HEL-S-62p FHL1 CP PMC2863215__F2 Regulation of mTORC signaling networks RHEB EGF TSC2 MAP4K3 RALA EGFR MTOR DEPTOR IRS1 PMC8779519__F3 Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis IFNG POLL TRADD HAL MAK ELL POLI TRAF3 LCN2 FADD PMC8779519__F2 Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis CD40 CXCR3 LTA OSM CCL3 IL27 CCR2 EPO CCL23 EPOR OSMR IL17RB CCR7 TPO IL17RC CXCR6 CSF2 RELT TNF LTB CCL13 CNTFR TSLP CCL19 IL8RB CXCR4 CCL8 IL23R EDAR IL10RB FAS LEP CD27 CCR3 MPL IFNK IFNGR2 CCR6 IL11 IL27RA IL10 IL13 LEPR NGFR CXCL16 IL20RA IL6 CNTF CXCL17 TNLG7C PMC3296254__F5 Arginine metabolic network CPA2 CPA1 ARG1 ARG2 PMC5432965__F2 Microarray profiling of 467 human GBMs discovered that polo-like kinase 1 (PLK1) was highly expressed in these tumors and that it clustered with the proliferative subtype CDC20 APC SMC3 POLE SLK PMC8779519__F4 Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis POR GFAP PMC3943829__F1 A scheme of metabolic pathway for cholesterol biogenesis EBP DHCR7 TM7SF2 MVK PMC8814461__F2 Emerging Roles of Circular RNAs in the Chemoresistance of Gastrointestinal Cancer STAT3 BAX HMGA2 PIK3R1 SOX2 PTEN MTOR CTNNB1 BMI1 FOXM1 SOX9 BRCA1 BCL2 POLD4 PMC5920642__F3 Cell proliferation and negative apoptosis regulation in the uterine leiomyoma MAPK1 HEL-S-99n HEL-S-269 HEL-S-102 BCL2 HEL-S-89n VCP PMC9331212__F1 Precision Medicine Highlights Dysregulation of the CDK4/6 Cell Cycle Regulatory Pathway in Pediatric, Adolescents and Young Adult Sarcomas CCND3 CCNE2 CDK6 CCND2 CDK2 MTOR CCND1 CDK4 PMC8740161__F3 Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells MON2 RFC4 RFC2 PCNA CDC6 HEL-S-11 CDT1 ORC1L ORC3 POLD2 POLE ORC2 PMC12197700__F2 Disruption of the SA signaling pathway by viral proteins SUMO3 C2 NPRC PMC12197700__F1 Signal transduction in the SA signaling pathway SUMO3 NPRC PMC6143874__F2 Binding of growth factors and hormones to their respective receptors or ligands serves a pivotal role in Beta-cell proliferation RAB43 TH TGFB1 PDX1 IGF1 FOXO1 CRTC2 CDK2 EZH2 PMC7814174__F3 GDF15 and FGF21 as mitokines in the diurnal regulation of energy balance NTS FGF21 GDF15 ARC PMC6143874__F1 Binding of PDGF, GLP-1, IGF-1 and BTC to their respective receptors serves an important role in Beta-cell proliferation APC EZH2 IGF1R CTNNB1 RHEB TSC2 TCF7L2 PDX1 TSC1 IGF1 FOXO1 CCND2 BTC ERBB2 MDM2 CCND1 CDK4 PMC6143874__F3 JAK-STAT signaling in tandem with multiple cytokines and hormones participates in the regulation of Beta-cells CCND3 FOXM1 CCND2 PRL EPO CCND1 CDK4 PMC6230558__F6 TRPV4 activation caused oligodendrocyte apoptosis and demyelination CPZ HEL-S-11 IL1B PMC8669714__F3 Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics ATG101 ATG12 ULK1 MTOR ATG5 BIK PMC5159445__F2 MetaCore Immune response_IL-17 signaling pathway IL17F IL17RC SP1 CCL7 TRAF6 CCL2 CCL20 PMC7464784__F2 Illustrating the metabolic components contributing to drug resistance and drugs to overcome the resistance PIM2 FRS2 HEL-S-133P HK2 EGFR HIF1A LDHB MTOR MYD88 TLR4 HSF1 FGFR4 EN1 ITGB5 PMC7464784__F1 An illustration of glucose metabolism leading from the glycolytic pathway to the tricarboxylic acid cycle (TCA) and electron transport chain (ETC) VIT ATR HEL-S-133P F2 HEL-S-162eP PMC9286619__F1 The androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments EGFR SRC PMC8442523__F2 TRPV1 in the pain pathway: similarities and differences between desensitization by agonists and blockade by antagonists NGF ITCH TRPV1 PMC6064203__F4 Integrative machine learning analysis of multiple gene expression profiles in cervical cancer ESPL1 LSM3 CKS1B PRDX3 BUB1B COPB2 SLC5A3 CCNA2 POLE PMC6064203__F3 Integrative machine learning analysis of multiple gene expression profiles in cervical cancer BTD NME2 PEG3 TNFRSF25 RPLP2 PMC8064071__F3 Scheme of the central carbon metabolism and carotenogenesis in C HEL107 RPE IPP PMC6022934__F8 Urea cycle and pyrimidine de novo biosynthesis pathway NAGS CAD OTC DHODH CP PMC4309523__F5 An example from dGCspALL2 MS4A1 CCR2 IL7R CTSS IRF4 POU2AF1 PTPRCAP ARHGDIB BTK TYROBP CCR7 HEL-S-66 LCK PMC2315681__F8 Leptin's roles in the endocardial cushion MMP14 MMP2 PMC3181269__F1 Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis and Signaling LPA MGAT1 HMFN0839 DGAT1 GPAT4 GPAT2 DGAT2 AGPAT3 MGAT2 PC PMC2762943__F1 Epidermal growth factor receptor (EGFR) pathway EGF TGFA EGFR PTEN GRB2 PMC11635611__F3 Crosstalk among microglia and astrocytes with neurons CXCR3 NLRP3 CXCL10 BDNF PMC2762943__F3 P53 pathway BAX FAS MDM2 MYC CCND1 PMC11635611__F2 Morphine tolerance-related signaling pathways inside microglia NLRP3 TLR4 EGFR BDNF PMC5323371__F3 Utilizing a combination of immunoprecipitation (IP) and tandem mass spectrometry (MS) protein identification (ID), complemented by gene expression analysis, a comprehensive Ang-(1-7) stimulated Mas1 receptor signaling pathway was generated CDC42 FLT3 PRKD1 NFATC4 MGRA GRIP1 NFATC1 RHO MTOR PMC8669714__F2 Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics ATG101 ATG10 ATG12 ULK1 ATG14 MTOR ATG5 PMC7261637__F8 Model depicts the proposed role of HPSE in promoting stemness HPSE HEL-S-53e SOX2 PMC8669714__F1 Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics RIPK3 TRADD MLKL RIPK1 TRAF1 TNF APAF1 BIK FADD PMC2668954__F4 Mechanotransduction gone awry EGR1 RHO GATA4 PMC3797199__F1 Aryl Hydrocarbon Receptor Promotes RORGt+ ILCs and Controls Intestinal Immunity and Inflammation LTBR KIT AHR NOTCH2 IL1B PMC5650460__F1 Dual roles of yes-associated protein (YAP) in colorectal cancer EGFR SHH MTOR PMC2849843__F2 Schematic presentation of Akt-mTOR signaling RHEB TSC2 RICTOR TSC1 MTOR PMC8063392__F5 LCK pathway regulates cisplatin resistance in endometrioid tumors. Downstream of CD55, LCK stimulates expression of DNA repair genes, leading to cisplatin resistance ROR2 CD55 LCK PMC2849843__F1 Schematic presentation of PI3K-Akt signaling TSC2 BAD TSC1 PAX8 PTEN MDM2 PDK2 PMC11634819__F8 Schematic diagram illustrating the signaling pathway through which A‐MG influences hypertension, hypertension‐associated vascular remodeling, and changes in uric acid levels HEL-S-14 ACE2 PMC7701524__F10 Schematic illustration of the potential molecular mechanism of miR‐148a‐3p as a tumour suppressor in PC WNT1 CCND1 CTNNB1 PMC7904608__F2 Metabolic regulation of trained immunity in HSCs HMGCR HK3 PFKP HEL-S-30 ABCA1 PMC7564431__F6 STRING protein interaction network of 61 out of 652 genes targeted by the selected miRNAs and directly involved in the breast cancer KEGG pathway (hsa05224) FZD5 PIK3CA RAF1 WNT3A PIK3R3 EGFR AKT3 RPS6KB2 GSK3B BRAF PTEN IGF1R MYC CTNNB1 RB1 FZD8 CDK6 FZD3 E2F3 FGF9 FGFR1 WNT9A NOTCH3 CCND1 NOTCH1 CDK4 BAX JUN FZD2 APC NOTCH2 WNT7B KRAS FOS FGF2 ARAF HRAS DDB2 TCF7L2 CDKN1A RPS6KB1 SOS2 ERBB2 DVL3 GRB2 GADD45A WNT8B PMC3722958__F2 The suggested interplay between natural killer (NK), CD4+ T, B cells, and polymorphonuclear cells (PMN) during pemphigus pathogenesis MAPKAPK2 MAPKAPK3 DSG3 PMC3722958__F1 P38 MAPK in the induction of pemphigus vulgaris (PV) MAPKAPK2 MAPKAPK3 DSG1 DSG3 PMC9047385__F1 Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease TLR4 CD14 TRAF6 LBP IRAK4 MYD88 PMC6073671__F1 Silver nanoparticles on the cell stress response pathways BCL2 PTEN ATF4 XBP1 PMC2957893__F3 Genes in one pathway have complex “net” interactions, which should be taken into consideration when analyzing proteomics/genomic data CDC2 CDK6 PCNA ATM MDM2 CDK4 PMC5190062__F8 ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis RAD51 ATF4 MGMT PMC7680862__F1 Mitochondria-associated ER membranes and cell physiology VAPB FIS1 NLRP3 OPA1 TXNIP C2 GPR75 PML MCU PTEN MTOR MFF PMC6803036__F2 Secreted IgM: New Tricks for an Old Molecule BCR HEL-S-62p GC ELL PC PREB PMC2866141__F4 Molecular Basis of Pulmonary Alveolar Proteinosis TIRAP MAL CD14 IRAK1 TRAF6 MYD88 PMC9168125__F1 Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy? SP1 CD7 TWIST2 PMC6144927__F1 TGFB signaling maintains homeostasis between the proliferation and apoptosis of normal epithelial cells by Smads or other Smad-independent downstream pathways SMAD2 SMAD4 MMP9 MYC PMC8904278__F3 Metabolic Rewiring by NRF2 HEL107 SLC3A2 HEL-S-304 PHGDH GPX4 GCLM GCLC PSAT1 SLC7A11 HEL-S-64p PSPH PMC6017900__F7 Signaling pathways for flaccidoxide-13-acetate in bladder cancer MMP2 ARHA GRB2 MTOR PMC8754418__F1 Congenital Micropenis: Etiology And Management SP1 DKK2 CTNNB1 PMC4905404__F2 Regulators of phenotypic plasticity CD44 HGF ABCG2 PMC10789540__F5 IFITM3-mediated activation of TRAF6/MAPK/AP-1 pathways induces acquired TKI resistance in clear cell renal cell carcinoma IFITM3 IRAK1 TRAF6 PMC2880413__F2 Networks for (A) Biological network (B) Network MDL approach (C) PMDL approach The performance on the algorithms is performed on a biological data set CDC20 SMC3 CDC27 PMC8639566__F1 Sensing Stemness CGAS MAVS IRF3 IRF7 TRAF6 PMC3874211__F4 Network pathway analysis integrated the majority of proteins identified as changed on 2DE (), as shown in but did not include S-methyl-5`thioadenosine phosphorylase, and lamin B1 because of low scoring NCALD TGFB1 DPYSL5 GLS TUFM PSMB2 PSMA2 DPYSL3 HEL-S-70p VCP HEL-S-276 STUB1 LRPAP1 APOA4 NR2A1 HNRNPH1 ACAT2 RCN3 PSMC6 HEL-S-49 RBP1 DLD HNRNPC HTT PMC4979452__F7 Cell adhesion NCAM2 MCAM NRCAM TRIO TIMP1 PTEN CTNNB1 CD44 CRK JAM2 GFAP PLAT FYN FER PAK1 PMC7805339__F1 Current understanding of the mechanism of action of luspatercept GDF10 GDF3 GDF11 SMAD2 GDF1 PS1TP5BP1 PMC4979452__F6 Protein kinase A (PKA) signaling pathway BDKRB1 PYGM GHRH HTR2A DDC AGTR2 GNRH2 RASA2 RAP1A EDNRA RGS4 MDM2 BDKRB2 PMC3820535__F7 Modeling Integrated Cellular Machinery Using Hybrid Petri-Boolean Networks CDC42 TF MAX GPD1 PMC4979452__F8 Cytoskeleton remodeling and axonal transport CDC42 OPA1 HEL-S-77 APOE MARCKS LINGO1 NTNG2 NEF3 RAC1 NEFH HRAS FARP2 GFAP SLIT2 ARHGEF1 CXCR4 DCTN1 SRGAP2 PMC1894940__F5 Inhibition of COX-2 modulates multiple functional pathways during acute inflammation and pain HPGD ALOX12B SOCS3 IL6 ALOXE3 ALOX15B PMC3296254__F7 Lysine biosynthetic pathway MKS1 HEL-S-26 PMC4979452__F3 Ion homeostasis CALHM2 SNAP29 NOG CFTR FXYD2 PMC9355504__F1 Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer SRRM4 STAT3 REST SPINK1 TGFA SOX2 TWIST2 FOXA2 IL8RB MTOR IGF2 PMC4979452__F2 Mitogen-activated protein kinase (MAPK) signaling pathway FLT3 EGF BAD SOS1 EGFR MAPK3 FGFR2 GRB10 RASA2 SP3 ATF1 MAP2K3 ETS2 NCK1 SP1 MAPKAPK2 FGF2 ATF3 GRB7 RASA3 SOS2 RAP1A ARHGEF1 MAP2K2 GRB2 GRB14 TRAF2 RET PMC6678596__F1 Representation of the main DNA repair pathways involved in platinum salts-induced DNA damage ATR RAD51 BRCA1 BRCA2 ATM PALB2 SSB PMC5560156__F1 Schematic overview of the molecular network involved in VSV oncoselectivity TBK1 LDLR IRF3 PTEN MTOR PMC4979452__F5 JAK-STAT (Janus kinase/signal transducers and activators of transcription) pathway STAT3 NMI EGF TGFA OSM EGFR CCR5 CS FANCE IFNG STAT1 AGTR2 IL2 ERBB2 PMC4979452__F4 PI3K-AKT (phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT) signaling pathway TRADD EGFR NGFR ARHGEF1 PTEN IGF1R APIP TNF IGF2 FGFR2 PMC3539919__F2 Simplified carbon metabolic network ENO2 HEL-S-68p HEL-S-49 HEL-S-32 PMC6032252__F1 The tumor microenvironment on myeloid cell differentiation and metabolism TBK1 CD80 HGF LIF S100A9 PMC12103044__F10 Examples of eExo for promoting chronic wound healing STAT3 SIRT3 HIF1AN TLR4 PTEN MTOR SIRT1 PMC8349099__F1 Calcium signaling in hepatitis B virus infection and its potential as a therapeutic target VDAC3 ORAI1 CD36 STIM1 CASP3 BCL2 MCU SRC PMC3048914__F6 Differentially expressed genes in the MICs as compared to NSPCs EGF FAS TIMP1 SP1 EGFR SPARC PTEN HAVCR1 CTNNB1 CNTF CDKN2A FLI1 IGF1 CCNE1 ETV4 PMC4937866__F13 AhRR repression on AhR activity and the consequences in endpoints TF AHR AHRR PMC6563055__F4 NOX4-related mechanisms in thyroid carcinogenesis TF NOX4 PMC3668263__F3 Wnt signaling pathways CDC42 APC RHO DAAM1 CTNNB1 PMC3668263__F2 LRRK2 regulates cell biological functions important for neurogenesis LRRK2 APC LRP5 LRP6 PMC3986808__F2 Copper is passed (green arrows) to cuproproteins (dark green circles), including metallothioneins Crs5 and Cup1, in for example Saccharomyces cerevisiae, by copper metallochaperones (pale green circles, or ovals if membrane associated) CCS COX1 COX2 SCO1 COX17 COX11 HEL-S-44 PMC6301151__F8 Schematic graphic of the mechanism underlying chondrogenesis driven by PC nanofiber membranes ACAN LTB SOX9 MSC PC TRAF1 VCAM1 TNF COL2A1 PMC2377014__F10 BDNF enhancement of glutamate-induced phase shifting in the SCN, and potential locations in the signaling pathway where ethanol could inhibit this process C2 GC SRC BDNF PMC9577160__F2 Promoter Methylation of Tumor Suppressors in Thyroid Carcinoma: A Systematic Review TIMP3 TSHR SI PTEN CDK4 RUNX3 PMC9146702__F1 An Insight into the Novel Immunotherapy and Targeted Therapeutic Strategies for Hepatocellular Carcinoma and Cholangiocarcinoma FLT3 MTOR TYK2 PMC6883840__F10 Proteins and metabolites in JK1 that change by >2-fold relative to wild-type E RPE RPIA HEL-S-162eP PMC6947886__F3 Differentially expressed genes in the estrogen signaling pathway TF POR BCL2 HEL-S-11 PMC3233269__F1 PA can be generated de novo,, by sequential enzyme-catalyzed acylations of glycerol-3-phosphate, or in response to cell signaling pathways () LPA HEL-S-5 PC PTEN MTOR LPP PMC9414909__F4 Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy BAX LPO PMC6757285__F1 Glutamine-dependent regulation of BMSC osteogenic and adipocyte differentiation GLS MTOR GOLPH2 PMC5386675__F3 Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin ATXN3 ERCC1 RAD18 XPA ATR ERCC2 SOS1 RCC2 CHL1 FANCM BLM SMPD2 TIAL1 MAEA SRCAP CHEK2 HLTF SNRPA APTX PC4 GALK2 XPC RPL15 DDB2 MLLT3 OGDH CHEK1 PIAS1 ERCC5 TIA1 PMC4997401__F5 Promoter-specific DNA methylation of genes in the Kyoto Encyclopedia of Genes and Genomes (KEGG) mitogen-activated protein kinase (MAPK) signaling pathway MAX ECSIT FAS RAF1 CD14 GRB2 NLK TRAF6 FLNA MEF2C PMC11648684__F8 M6A on apoptosis BAX MCU PTEN YTHDF1 METTL3 IGF2BP2 MYC PMC8989557__F2 Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy HEL-S-92n STAT3 STAT1 STAT2 CTLA4 JAK1 PMC8989557__F1 Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy CD40 FAS PMC9239699__F3 ERH Interacts With EIF2A and Regulates the EIF2A/ATF4/CHOP Pathway in Bladder Cancer Cells RPL27A TARDBP RAN CHTOP RBM22 RPL31 RPS4X RPLP0 RPL7A FBL RPL23 HEL-S-130P PTBP1 HAL RPL29 RPL10 RPS9 PMC8551388__F3 Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica KEAP1 APP IL1B PMC3233269__F9 G protein-coupled receptors (GPCR) trigger dissociation of GA and GBG heterotrimeric G proteins upon agonist stimulation LPA GAA PC ARHA RHO LPP PMC6446704__F2 Regulation of FABP4/aP2 secretion from adipocytes TG FABP4 PMC3227953__F1 PI3K/Akt/mTOR pathway signaling in tumor and vascular endothelial cells OTOR VHL PMC5735818__F1 Schematic overview of the TEK signaling pathway which was built with CellDesigner 4.4 PTEN SHE MYC RET OTP PMC5133984__F6 Schematic diagram showing the signaling pathways leading to METH- and gp120-induced autophagy MTOR ATG5 PMC8064670__F1 GM-CSF signaling pathways OSM PIM1 IRF4 PMC8338747__F1 ExTreg generation STAT3 RUNX1 CBFB IL33 PTEN HIF1A FOXP3 MTOR STUB1 GATA3 PMC7374866__F7 B.coccineus ethanol leaf extract induces cell cycle arrest and apoptosis via the p53 dependent pathway BAX BAD CDK4 PMC3279755__F1 Signaling pathways of the fibroblast growth factor receptor in neural stem cells CBL GRB2 PMC6296511__F3 Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study C6 BDKRB1 SERPIND1 SERPINF2 CPB2 KLKB1 C3AR1 HEL-S-62p F5 F7 CR2 C1QB C4A CR1 PLAT CFI F2R CLU F2 F10 F3 PROS1 C9 THBD A2M F9 C4B_2 PROC KNG1 SERPINC1 C8G C7 SERPING1 MASP2 C1S PLAUR SERPINA1 PLG MASP1 C1QA TFPI C2 PMC3148577__F1 Metabolic networks of Corynebacterim glutamicum (a) and Brassica napus (b) corresponding to the experimental fluxes measured by and respectively HEL114 VASP MAL AIDA CIT PMC3148577__F3 A heterotrophic plant cells VASP MAL CIT PMC6885181__F5 HIF-1-miR-219-SMC4 axis regulates proliferation and migration of HCC under hypoxic condition CDK2 CDK4 SMC4 PMC11678862__F2 Dietary restriction on lipid profile changes and healthspan NR1C1 IGF1 FOXO1 PMC11049451__F3 Estrogen biosynthesis pathway from cholesterol to estetrol with the enzymes involved HSD3B2 CYP17A1 CYP11A1 CYP3A4 PMC11678862__F1 Molecular mechanisms linking dietary restriction to lipid metabolism and health benefits RHEB TSC2 TSC1 IGF1 CYP7A1 PTEN PMC5314358__F8 Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGFB1 KLF4 KLF2 SELE SMAD2 SMAD6 DKFZp686P11128 VCAM1 TRAF6 CCL2 CXCL8 PMC10385841__F6 Top networks associated with lipid metabolism identified in PIEs infected with G5P HIC1 PCDH18 CDON PCDH7 KMO CLSTN2 NKX3-2 PFKFB2 MYO1F ADAMTS8 MRC1 HDAC9 FLRT2 PMC8551388__F1 Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica KEAP1 APP IL1B PMC10385841__F5 Top networks associated with lipid metabolism identified in PIEs infected with G9P[13] ADM FA2H ETV3 B3GALT2 DFFB ARHGAP36 CLN3 CIDEB NAAA CCDC34 PBX3 STON2 TMCO2 GALNS FAM241B TM4SF20 SUSD6 OCIAD2 ANO7 AHNAK PMC10385841__F4 Rotavirus interactions with the host innate immune system IFNE MAVS STAT2 IRF9 IRF3 IL6 STAT1 CCL28 CCL25 IFNAR2 IFNAR1 MX1 OAS1 PMC5569936__F7 Metabolic control involved in aging and on the cardiovascular system TGFA IGF1 MTOR PMC11535070__F4 Proposed crosstalk model between TET1, WNT, mir200b, and miR494 in CRC progression BMI1 APC ZEB2 CTNNB1 PMC8996963__F2 Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue TF LPL VWF MMP14 FAS NOX5 CD36 MMP2 PMC11857948__F9 Selected differentially significant signaling pathways in M STAT3 PIM1 CXCL1 IL7R CXCL2 MMP9 MTOR CXCL8 RAC1 MYD88 CSF3R COX2 OSMR TLR4 IL17RB MMP3 CCL20 LBP PMC6236061__F1 PPAR signaling pathway LPL ACOX1 NR1C1 FABP1 PMC9445132__F3 Mitophagy: A potential therapeutic target for insulin resistance PINK1 ULK1 BNIP3 SQSTM1 FUNDC1 SRC PMC2655678__F1 ATM activation in response to DNA DSBs FANCD2 RAD50 MRE11A BRCA1 CDK2 ATM MDM2 MDC1 PMC9126300__F2 Deciphering the Link Between ERUPR Signaling and MicroRNA in Pathogenesis of Alzheimer’s Disease ATF4 EIF2A XBP1 TRAF2 PMC5627649__F5 Signaling and gene regulatory networks in mammalian lens development CDH2 LRP5 HEL-S-28 LRP6 CRIM1 NF2 PMC9126300__F1 Deciphering the Link Between ERUPR Signaling and MicroRNA in Pathogenesis of Alzheimer’s Disease ATF4 EIF2A XBP1 TRAF2 PMC5627649__F4 Signaling and gene regulatory networks in mammalian lens development CRYBB1 PROX1 HSF4 CRYAA PAX6 PMC3959225__F5 Pharmacogenomics of insulin-like growth factor-I generation during GH treatment in children with GH deficiency or Turner syndrome BAD IGF1 APP PMC11791135__F6 Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regulation MYB EIF4B BAD RBL2 PTEN CD19 RAC1 RHEB TSC2 BRCA1 BCR MEI1 CDC37 PROC PMC5752874__F3 HMGB1 receptor and possible signaling pathways CDC42 HMGB1 SLA PMC8478908__F2 TNFA/TNFR1 signaling activates necroptosis and triggers apoptosis and inflammation RIPK3 FAS TRADD C2 MLKL TLR4 TAB3 RIPK1 CYLD TRAF2 FADD PMC6957738__F1 ERBB and signaling effectors in PKD AQP2 TPR EGF HBEGF TGFA ERBB2 CFTR PTEN GRB2 SRC AVP PMC7202494__F7 Let-7f-5p/TARBP2 regulatory feedback loop in OS cells, which is induced by hypoxia and reduces the expression of let-7f-5p and TARBP2 in OS cells TARBP2 GSK3B CTNNB1 PMC6751321__F9 Diagram of the signaling mechanism involved in the myocardial protection mediated by carvacrol TRPA1 TRPV3 PTEN PMC8834070__F2 Shifting the Focus of Signaling Abnormalities in Colon Cancer EGF EGFR GRB2 PMC5936719__F1 Summary of unfolded protein response ATF4 EIF2A XBP1 PMC8834070__F4 Shifting the Focus of Signaling Abnormalities in Colon Cancer JUN CDK6 CCNE1 CDK2 TCF4 MYC CCND1 FOS CDK4 CTNNB1 PMC4872452__F2 Network analysis of blood transcripts CD59 IFNA16 C7orf21 MARCKS CMAS IRF3 GPR84 DGKA ADCY3 CDR2 STOML3 AMFR GMFG PMC2673242__F1 Loss of PTEN function results in accumulation of PIP3, which activates a cascade of signaling molecules BAD ELL PTEN MTOR PMC4381588__F1 Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma LIN28B EIF5A PMC2268054__F2 Mutations in the glycoprotein 130 (gp130) receptor lead to an imbalance in downstream signalling pathways STAT3 STAT1 SOCS3 JAK1 PMC8026307__F2 FOXO1 activity by periodontal microbiota in gingival epithelial cells PRDX3 TRADD FOXO1 ZEB2 NLK PMC2268054__F1 Role of glycoprotein 130 (gp130) downstream signalling in the heart STAT3 STAT1 OSM LIF IL11 GRB2 JAK1 PMC5655319__F1 Update on the therapeutic significance of estrogen receptor beta in malignant gliomas CRP EGR1 SP1 PTEN TSN MTOR PMC2915629__F4 Identification of RON-targeting genes JUN UBC TP53BP2 PTPRU RBBP6 PRKCZ HOXA11 YY1 FOS SLC6A2 LMX1B RB1 ATF3 TCF3 HCFC1 FGFR3 GHR PMC9107227__F7 Positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression STAT1 CXCR1 NFKB1 IL8RB CXCL8 PMC6685392__F4 Multi-loop model of AD: an integrated perspective on the Wnt/GSK3B, Alpha-synuclein, and type 3 diabetes hypotheses IDE DKK1 GSK3B PMC10216514__F5 Ferroptosis signaling pathway TF GLS GPX4 HEL-S-64p PMC1766919__F1 Signalling footprints of the TNF/TNF-R superfamily TRADD TRAF5 TRAF2 FADD PMC6685392__F1 Dysfunctions in canonical Wnt-Signaling contribute to the neuropathology of Alzheimer disease (AD) DKK1 GSK3B LRP6 APP CTNNB1 PMC3977149__F1 p53 effects multiple areas of cellular metabolism TIGAR SCO2 GLS2 PMC11607912__F3 Differentially expressed genes and DNA (hydroxy)methylation levels within the TRP metabolic pathway and NAD pathway GOT2 PARP4 NAPRT CYP8B1 DHTKD1 CYP2E1 HEL-S-90n KYAT3 DHCR24 NMNAT2 SLC7A5 PARP1 IDO2 PNP NADK HAAO DLD NADSYN1 SIRT1 NT5M PMC11607912__F6 Gene regulatory network (GRN) of TRP and NAD pathway SLC3A2 EHHADH SIRT7 CYP2E1 HEL-S-53e SIRT2 SLC7A5 MAOA SIRT3 ACAT1 ALDH2 SIRT6 CYP1A2 GCDH HEL-S-90n PARP14 NAMPT PTGS2 CYP1A1 PARP1 IDO2 ACAT2 PTGIS OGDH IDO1 CYP2J2 DLD ALDH1A2 CYP3A4 SIRT1 PMC7999074__F2 Activity of YAP/TAZ is influenced by various metabolic cues OGT FAS PFKFB4 SLC1A3 HEL-S-133P HK2 SLC38A1 MTOR SLC7A5 RHO CTNNB1 HMGCR HEL-S-68p PFKP PSAT1 PMC7999074__F1 Hippo signaling pathway comprises a cascade of phosphorylation and activation of kinases, which ultimately regulate YAP and TAZ subcellular localization LATS1 NF2 VGLL4 PMC8222692__F3 Treg: A Promising Immunotherapeutic Target in Oral Diseases CCL22 APC IL33 CCR4 FOXP3 MTOR PMC11891403__F6 Exogenous fatty acids inhibit fatty acid synthesis by competing with endogenously generated substrates for phospholipid synthesis in Escherichia coli LPA HEL-S-5 FADD PMC8704804__F1 Association of Genes of the NO Pathway with Altitude Disease and Hypoxic Pulmonary Hypertension AGXT2 HEL-S-277 ARG1 ARG2 PMC4468904__F6 Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis TDO2 INMT IDO1 KYNU KMO AANAT ASMT AOC2 AADAT DDC PMC5904768__F3 DNA damage stress response in the TRIM59 network MDM4 AURKA ATR HIPK2 C13orf34 WEE1 CHEK2 ATM RPRM EP300 MDM2 TRIP12 PMC5904768__F5 p53 signaling in the TRIM59 network TOPBP1 ATR HIPK2 CCND2 CHEK2 CDK2 ATM EP300 CDK4 PMC8129027__F1 Study of the Regulatory Mechanism of the CB1/PPARG2/PLIN1/HSL Pathway for Fat Metabolism in Cattle PPARG PDE3B ACSL6 ACSL5 ACSL3 FOXO1 FACL4 FABP4 SIRT1 IRS1 PMC11768235__F1 Exosome-mediated communication between immune cells and keratinocytes contributes to the development of psoriasis OLFM4 IL24 IL36G PMC6280699__F8 Proinflammatory and anti-inflammatory effects of IFNB in CF: (A) IFNB triggers JAK/STATsignaling pathway activation (STAT1, STAT3, and STAT3 proteins) STAT3 STAT1 STAT2 PMC8509311__F1 Impact of Selenium Deficiency on Cardiovascular Function SELENOK MSRB1 SEPHS2 SELENOP SELENOW SELENOT PMC7238364__F5 PPI network analysis of the overlapping DEGs LRP8 PSMD11 ORC6 MYBL2 RELB RNF169 SLC35B1 SRP68 TUBB KLHL2 PSMD2 CWC27 KAT7 TUBA4A NEDD4 USP2 DHX16 NFKBIA TDRP BRD2 PMC8909279__F2 Nutrients against Glucocorticoid-Induced Muscle Atrophy TSC2 GABARAPL1 SMAD2 ELF2 BNIP3 MTOR EIF4E PMC7795823__F6 Proposed mechanisms for the action of ACF on melanoma cells under normoxic conditions PDPK1 ELF2 ATF4 PMC10149906__F1 Building on the backbone of CD47-based therapy in cancer: Combination strategies, mechanisms, and future perspectives HEL-S-92n CGAS SIRPA CD47 PMC11018997__F6 Multiple functions of the nonstructural protein 3D in picornavirus infection MAVS IFNAR2 IRF9 NOD2 TANK IRF3 IRF7 TYK2 PMC11046940__F3 Regulation of autophagy to affect radiosensitivity involves a complex network of signaling pathway STAT3 HMGB1 ULK1 ATM PTEN MTOR SRC PMC6122069__F1 Two major signaling axes in IGF-1-mediated EMTs in human breast, lung, and gastric cancers STAT3 DDR1 IFITM2 ANXA2 IGF1R TM4SF4 IRS1 CTNNB1 IGF1 MUC1 ZEB2 GRB2 SRC TWIST1 PMC11046940__F2 Mechanisms by which autophagy modulation affects chemosensitivity are multifaceted and involve multiple signaling pathways ATG101 ATG10 MLST8 ATG3 ATG16L1 ATG12 ULK1 SQSTM1 ATG5 ULK2 PMC2852400__F7 Inhibition of the Proprotein Convertases Represses the Invasiveness of Human Primary Melanoma Cells with Altered p53, CDKN2A and N-Ras Genes CDKN2A BRAF MDM2 CDK4 PMC8306625__F1 PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases NOXA1 TIRAP TLR4 IRAK2 PSG1 DUOX2 TRAF6 NOX4 IRAK4 MYD88 PMC8527034__F7 Astragalus Polysaccharide Reduces Blood Pressure, Renal Damage, and Dysfunction Through the TGFB1-ILK Pathway SMAD2 HEL-S-28 PMC8306625__F3 PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases MAVS NLRP3 TXNIP NLRP2 PMC8142022__F4 Metabolism and cell signaling in ferroptosis BAP1 FACL4 NF2 PMC3989988__F1 De novo serine biosynthesis diverges from glycolysis PHGDH COX4I1 TIGAR GLS2 PSPH PMC8223745__F1 Current Challenges and Future Perspectives of Renal Tubular Dysfunction in Diabetic Kidney Disease STAT3 STAT1 HMGB1 SGK1 KLF6 MFN1 TLR4 IRAK1 ATF2 JAK1 IRAK4 MYD88 PMC11796622__F5 IL17RA mutation and downstream signaling pathway IL17RC EBP TRAF6 PMC7892335__F1 Loss and revival of androgen receptor signaling in advanced prostate cancer RB1 AURKA NGF FOXC2 SOX2 EZH2 ARSI PMC5697417__F2 IFITM proteins are involved in various cellular processes with direct and indirect impacts on immunity BAG3 FITM2 IGF1 AMBRA1 IRF3 MTOR SRC INS PMC5731828__F1 An emerging role for the ribosome as a nexus for post-translational modifications RPS15 RPS6 RPS20 RPS10 TCOF1 RPS3 RPL13A RPS2 PMC7281607__F1 Simpified major metabolic pathways of tryptophan (TRP) in humans KYNU KMO PMC4445995__F2 Stem cell response to matrix stiffness by integin, cytoskeleton and signal transduction crosstalk GATA2 NR1B3 ARHA MAP2 GRB2 GATA4 RUNX2 YAP1 PMC98951__F2 Signaling pathways of IFNA, IFNB, and cytoplasmic dsRNA STAT1 JAK1 TYK2 PMC4082998__F1 Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes FXYD7 EGFR SRC PMC11907956__F5 PTMs of CD47: When CD47 on the surface of tumor cells interacts with SIRPA on macrophages, it causes the intracellular portion of SIRPA to be phosphorylated SIRPA CD47 TRIM21 PMC12021826__F10 Schematic diagram illustrating how AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway during inflammatory responses GSDMD TLR4 EGFR RPLP1 AREG MYD88 PMC11907956__F4 Structure and PTMs of PD-L1 (phosphorylation, glycosylation and ubiquitination): Presented here is a schematic diagram that illustrates the functional domains of PD-L1 as well as its diverse PTMs EGF NEK2 GSK3B USP9X GLT1D1 B3GNT3 TRIM21 ARIH1 RNF125 SPOP GSK3A NEDD4 USP22 CMTM6 JAK1 USP21 CDK4 PMC4638047__F7 Pathway analysis highlights APP is a central hub interacting with nearly 40% of candidate molecules in EGS PFDN2 FKBP5 STXBP1 ENSA AGRN PARVA MBP NENF SNAP25 PFDN6 PMC6549079__F5 Signaling pathways related to RUNX3 SMAD4 TCF4 BRD2 CTNNB1 RUNX3 PMC6549079__F4 Signaling pathways related to RUNX2 EGF EGFR SMAD2 GSK3B ZEB2 PTH RUNX2 CTNNB1 PMC11537862__F3 Possible pathways of apoptosis inhibition by Brucella SDHB NEDD4 NME2 HEL-S-29 NDUFS6 DDIT3 PMC6549079__F3 Signaling pathways related to RUNX1 EGF RUNX1 EGFR GSK3B ERBB2 CTNNB1 PMC11537862__F2 Brucella triggers inflammatory responses NLRP3 TXNIP NOD2 AIM2 TRAF2 MYD88 PMC11876635__F7 SEMA3F-dependent pathways NRP2 MTOR PMC11907956__F8 PTMs of TIGIT: TIGIT binds to CD112, CD113, and CD155 TIGIT APC GRB2 TRAF6 PMC4705549__F5 Multiple functional linear model for association analysis of RNA-seq with imaging SFRS8 TMEM258 PROZ CCDC71 MRPL33 NDUFS4 PMC6371002__F2 Mechanistic cross-connection between the transforming growth factor beta pathway and bone morphogenetic protein signaling BMPR2 TFR2 HAMP HFE PMC6274916__F2 Complement activation by foreign biomaterial surfaces in bone tissue, and strategies to modulate the complement system HEL-S-62p MSC CR1 CP PMC2819049__F3 Different components of shelterin are dedicated to different aspects of the end-protection problem ATR ATM POT1 PMC1389768__F1 The Challenge of Characterizing Operations in the Mechanisms Underlying Behavior C6 C2 PMC10376170__F2 Targeting Triple-Negative Breast Cancer by the Phytopolyphenol Carnosol: ROS-Dependent Mechanisms STAT3 BAX ATF4 MTOR PMC6512804__F6 Fatty livers demonstrate a premalignant signature CASP9 DCC FH SUFU APC CASP3 SHH SMO PTEN RHO VHL PMC7870817__F5 GSK3Beta-Beta-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a GSK3B YY1 CTNNB1 PMC8105434__F8 Trueperella pyogenes pyolysin inhibits lipopolysaccharide-induced inflammatory response in endometrium stromal cells via autophagy- and ATF6-dependent mechanism NLRP3 IL1B PMC8584071__F3 Epithelial to Mesenchymal Transition: A Challenging Playground for Translational Research. Current Models and Focus on TWIST1 Relevance and Gastrointestinal Cancers STAT3 GSK3B HIF1A TWIST1 CTNNB1 PMC8215263__F1 Effect of Oxidative Stress on Diaphragm Dysfunction and Exercise Intervention in Chronic Obstructive Pulmonary Disease UCP2 TNF PMC11966298__F4 Applications of metal-based nanomaterials in tumor immunotherapy TBK1 CGAS IRF3 PMC11966298__F1 CGAS-STING pathway CXCL9 CGAS IRF3 CXCL10 TNF PMC9403721__F1 Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds ATG101 ATG10 ATG3 ATG12 ULK1 UVRAG ULK2 PMC2753670__F3 Integration of ITAM and cytokine Jak–STAT signaling SYK STAT1 JAK1 TYK2 PMC6016592__F2 The two faces of pannexins: new roles in inflammation and repair PANX1 GSDMD IL18 IL1B PMC6763828__F9 Schematic model of intracellular signal components that control S-phase entry in vestibular epithelia from neonatal mammals PI3 ERBB2 HEL-S-11 PMC2799977__F2 TLR signaling upon intrinsic cellular defenses TBK1 TRAK1 TLR9 IRF3 IRAK2 TRAF3 TRAF6 MYD88 TLR1 TLR3 TLR8 TLR7 IL1B PMC5690809__F7 Histone acetyltransferase KAT6A upregulates PI3K/AKT signaling through TRIM24 binding PIK3CA BRPF1 TRIM24 KAT6A PMC4172307__F1 Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors FAS HEXA RELA MTOR EIF4E PMC5890159__F1 Nutrient activation of PKA in the yeast RGS2 GIP PDE12 PMC10487526__F9 Proinflammatory immune response in BV-2 microglial cells induced by NfEVs STAT3 JAK1 PMC9492833__F2 Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy BET1 VPS33A VAMP2 STX6 VAMP3 ATG14 STX8 STX17 EEA1 VAMP8 VAMP4 VAMP7 USE1 SEC22B STX5A STX16 STX18 STX7 PLEKHM1 SYT2 BNIP1 STX3A PMC5289991__F2 MYC-driven self-reinforcing loop in ESCs MAX AEBP2 APC LIF SOX2 GSK3B LRP5 LRP6 MYC DUSP2 DUSP7 PMC7283439__F7 FG-4592 activity on depression HOMER1 EPO BDNF PMC5289991__F1 MYC regulatory networks in pluripotent stem cells HDAC1 STAT3 PRMT7 AEBP2 HEL-S-133P DKK1 LIF MYC DUSP2 SFRP1 DUSP7 PMC3798916__F1 Methylation cycle PEMT HEL-S-61p PMC9403519__F9 Posaconazole inhibits the stemness of cancer stem-like cells by inducing autophagy and suppressing the Wnt/Beta-catenin/survivin signaling pathway in glioblastoma CD44 SOX2 ATG5 CTNNB1 PMC3185579__F3 TLR-dependent and independent IFN-I induction, signaling and action TBK1 STAT2 IRF9 TLR9 RNASEL IRF3 IRF7 ATF2 MYD88 ISG20 TRIM50 STAT1 TLR3 MX1 TLR7 ISG15 JAK1 TYK2 PMC7394593__F1 The roles played by the TCA cycle and the Warburg effect in gastrointestinal cancers and normal tissues PFKFB4 FH CGA CUEDC2 BRD7 OGDH HEL-S-133P PFKP HEL-S-32 HMGB2 PMC9646879__F7 Various biological functions of the human Rix1 scaffolding complex PELP1 TEX10 SENP3 PMC6532258__F7 Proposed model for GPAA1 promoting growth and metastasis of gastric cancer GPAA1 EGFR ERBB2 PMC8430477__F6 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway CDH2 CXCL12 FBXL14 NR2A2 MTOR CXCR4 PMC8430477__F5 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway SLC3A2 GPX4 SLC7A11 PMC3213329__F3 Ingenuity pathway analysis of phosphatidylinositol 3-kinase (PI3K) signaling pathway affected by angiotensin II RHEB BAD PTEN MDM2 MTOR CTNNB1 EIF4E CP PMC8430477__F7 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway PDCD1 CXCL1 DACH1 FOXP3 PMC8430477__F2 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway BAX KEAP1 ATF4 VCAM1 VEGFA SIRT1 PMC8430477__F1 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway SIRT3 HEL-S-2a ULK1 GPX7 MTOR EIF4E PMC5358377__F6 Cellular localization of the autophagy genes regulated by 1,25(OH)2D3 (Ingenuity Pathway Analysis software) in MCF-7 cells ATG10 ATG3 WDFY3 HEL-S-62p BCL2 MTOR STX17 PMC4228291__F1 Wnt signaling pathway and its key components APC LRP5 LRP6 CTNNB1 PMC8430477__F4 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway BAX PELP1 DFNA5 SIRT1 PMC8233448__F1 NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies NLRP3 IL1B PMC8430477__F3 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway RIPK3 MLKL RIPK1 PMC12241215__F3 Diagram represents various therapeutic strategies targeting AML through different molecular mechanisms MAX BAX FAS CD33 SMO MDM2 PMC8523334__F3 TNFR2+ Tregs in COVID-19: An overview and a potential therapeutic strategy TRAF1 TRAF3 TRAF2 PMC9458863__F3 Current progress of ferroptosis study in ovarian cancer SLC3A2 GPX4 EGFR FZD7 FACL4 SLC7A11 MTOR SKP2 PMC1351175__F11 Proposed Receptor Ck – dependent signaling pathway involved in hTERT gene regulation at the transcriptional level SP1 LDLR PC APOB PMC11519599__F3 Signal transduction pathways in ferroptosis under HS SLC3A2 GPX4 TLR4 FACL4 SLC7A11 TEAD4 PMC7182338__F4 BCR signaling pathway and its targeted inhibition SYK BTK BCR PLCG2 CCL3 BLNK CD19 CCL4 LYN BCL6 PMC4137125__F3 Schematic representation depicting deleterious effects of overnutrition and obesity in the vasculature and targets for DPP-4i TH TGFB1 CAD DPP4 IRS1 PMC11519599__F2 Signal transduction pathways of necroptosis under HS RIPK3 ZBP1 TRADD TLR3 MLKL HSF1 RIPK1 TRAF2 FADD PMC3070844__F3 Top-scoring network created by Ingenuity Pathway Analysis HYOU1 ANXA2 NPM1 SERPINB2 PPP2R1A HEL-S-97n PMC8103163__F7 Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1B/CXCL1 Signaling GSDMD NLRP3 TLR4 IL1B PMC8290830__F4 Autophagy in hepatic fibrosis ATG12 ULK1 MTOR ATG5 PMC11934544__F7 Protective mechanism of EA on IVDD MAP1A AQP3 MAP1B ELF2 MAP2 AQP1 PMC8290830__F2 Autophagy in hepatic fibrosis HMGB1 ATG12 ATG9A ULK1 ALG13 MTOR ATG5 PMC9471313__F3 Excessive intake of sugar: An accomplice of inflammation COX2 TLR4 LCN2 TNF IL1B PMC7586926__F1 SARS-CoV-2 pathogenesis TMPRSS2 CTSL ACE2 PMC3323898__F5 Graphical representation of the known connections between the Wnt/Beta-catenin pathway and the Notch1 signaling pathways, according to the knowledge of the current literature MMP7 MMP14 HEY2 SGK1 NKD2 APC NRARP NUMB MYC CTNNB1 HRAS NEDD4 MDM2 FHIT LEF1 CCND1 NOTCH1 PMC4365881__F4 Extracellular regulation of satellite cell fate SDC4 PAX7 SDC3 CTNNB1 FGF2 PMC9139349__F2 Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping TF TFAM FIS1 OPA1 MFN1 MFN2 NRF1 PMC5290970__F8 Signaling switch between hyperglycemia and normoglycemia PI3 GRB2 IRS1 PMC6656753__F5 Significant dysregulation of P53 pathway in urothelial cells exposed to either S RFWD2 BAX CASP9 ATR FAS SIAH1 PML PTEN MYC TSC2 FER CASP3 CDK2 ATM PIGS MDM2 PMC6656753__F4 Significant dysregulation of genes involved in Colorectal Cancer Signaling Pathway in urothelial cells BAX CASP9 EGF DCC BAD MSH2 MSH3 APC CASP3 SMAD4 RHO CCND1 PMC7520849__F1 RAD51 function during HR and replication fork reversal and protection CDX2 RAD51 DNA2 BRCA1 BRCA2 GEN1 PALB2 SLX4 PMC7020766__F3 Pathway of diabetic cardiomyopathy network (Blue circle stands for breast cancer gene SOCS1 NR1H2 STK11 LEP SLC2A4 CD36 ATP2A2 IGF1R SOCS3 MTOR INS CCL2 CSF3 PRKCB CDKN2A YWHAQ TLR4 NOD1 IL1B LPL MMP7 NR1H3 AGTR1 ARHA TNF SPP1 ANGPTL4 HMGCR IGF1 ELAVL1 FOXO1 CAMK2D KLNA1 EDN1 EDNRA CYP2J2 BDNF GADD45A CAMK2G SIRT1 PMC6679874__F4 Regulation of genes and myomiRs expression in the IGF/PI3K/Akt signaling pathway during myogenesis MYOG FOXO3A SMAD2 MYF5 PTEN MTOR PAX7 MEF2C MYH2 PMC5161695__F7 Glucose metabolism reprogrammed by overexpression of IKK-epsilon promotes pancreatic tumor growth HEL107 HEL-S-133P HEL-S-68p HEL-S-49 HK2 GSK3B PFKL GCK PCK1 PKLR PMC4395454__F1 MLK3 Phophorylates AMPK Independently of LKB1 CDC42 MAP2K4 MAP6 MAP2K1 MAP2 MAP2K3 PMC7273095__F1 Androgen sensitivity gateway to COVID‐19 disease severity TMPRSS2 ACE2 PMC3800061__F2 Basic NOD2/RIP2 pathway of NFKB activation TAB3 TRAF5 NOD2 TRAF6 TRAF2 PMC12236749__F3 BMSC-Exos alleviate MIRI STAT3 BAX SIRT7 TNFSF6 BAP1 FACL4 PTEN SLC7A11 PUM2 HEL-S-128m IGF1 FOXO1 TLR4 MFN2 A2M KLF13 HEL-S-44 PMC3251532__F5 The lymphocte-specific gene (A) or urine peptide (B) markers ZNF107 HCCS ABCC1 CCND2 NBN UCN PTPRCAP PMC12236749__F2 BMSC-Exos ameliorate MI MAP3K2 BAX HMGA2 ANGPT1 NLRP3 ITCH TLR4 BNIP3 EZH2 PTEN ADAMTS16 HEL-S-44 PMC2718437__F4A Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor B SERPINF2 PLAT PLAUR PLG SERPINB2 PMC12236749__F5 BMSC-Exos ameliorate other CVDs KLF4 HMGB1 IGF2BP1 SMOC2 NLRP3 FOXO1 TLR4 RAC1 CTNNB1 PMC6683488__F1 Molecular landscape of SCLC RB1 STAT3 AURKA STAT1 ATR ASCL1 WEE1 SLFN11 IRF1 ATM EZH2 MYC PMC11667561__F7 Illustrates the TCA cycle, MVA Pathway and downstream of saponins synthesis metabolic pathway RB1 IPP F2 PMC12236749__F4 BMSC-Exos improve AS GSDMD HMGA2 NLRP3 KEAP1 PTEN ABCA1 CEBPB PMC539208__F2 MAPK pathway JUN BRAF CR2 MYC CR1 FOS AKAP9 PMC9604498__F10 Model integrating the network involving Churc1, Nodal and Notch-dependent pathways in the induction and segregation of germ layers in the Xenopus MZ HES4 CHURC1 SOX2 NODAL ZEB2 TBXT NOTCH1 PMC3956974__F3 Signaling control of CAR activation PGC EGF EGR1 EGFR GRIP1 PMC12236749__F6 Cardiovascular-derived exosomes regulate the bone FZD3 DKK2 CTNNB1 PMC11395599__F4 Illustration of NETs, ROS, cancer mitochondrial oxidative damage and altered glucose metabolism, including the Warburg effect and glucose metabolic reprogramming, in human cancers is shown MTHFD2 MTHFD1 GLS PHGDH PSAT1 PSPH PMC9456504__F1 Antimicrobial Peptides in Gynecological Cancers NR1i1 CDH2 CYP27B1 SLPI CCND1 PMC4248747__F8 Proposed model for the control of Beta-catenin stability by RNF220/USP7 APC CTNNB1 RNF220 PMC3483307__F5 Novel Genes and Pathways Modulated by Syndecan-1: Implications for the Proliferation and Cell-Cycle Regulation of Malignant Mesothelioma Cells EGF JUND TGFA EGFR SMAD2 RELB HS2ST1 MYC FOS TGFBR1 NFKBIA SULF1 CDK2 GRB2 MAP2K3 DCN PMC7338561__F2 Depiction of the modulation of NFKB signaling pathway by gastric microbiota, especially H NOD1 CTNNB1 MYD88 PMC8698353__F5 Effect Mechanism of Electroacupuncture at ST36 on the Injured Extensor Digitorum Longus in the Jumping Rat Model Based on mRNA-Seq Analysis BAX CDKN2A CASP3 BCL2 APP CISH MYC PMC4594238__F8 Sensory initiation of a co‐ordinated motor response: synaptic excitation underlying simple decision‐making TG MB PMC9532118__F1 E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration RARA SMAD1 SMURF1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 TNF PMC9641500__F2 Lysophospholipid Mediators in Health and Disease LPL LPA MFSD2B SPNS2 SPHK2 SPHK1 PC LPP PMC6745708__F1 The RTK signaling network and nodes of therapeutic blockade EGF HGF ALK GDNF EGFR IGF1R MTOR RET PMC6943215__F1 The ‘Metro-Rail Concept’ to targeted therapy of the pathophysiology of cirrhosis HGF CD14 PMC12001479__F4 Key molecular mechanisms governing mitochondrial dynamics, biogenesis, and mitophagy TFAM PINK1 OPA1 MFN1 MFN2 MTOR OPTN PMC3438338__F7 Interferon-Gamma-induced glial cell activation by transforming growth factor B1: A role for STAT1 and MAPK pathways STAT1 TGFB1 GRB2 JAK1 TRAF6 PMC2790720__F2 IRF4: Immunity. Malignancy! Therapy? STAG2 CDK6 SCD PRDM1 SQLE PC IRF4 PC4 MYC CCNC PMC5515402__F3 Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids HSP90AB1 INSRR HSPA14 HEL-S-162eP ASGR2 OSTM1 KLHL38 FLNA TSSK1 PMC3304673__F1 Association of the canonical interferon pathway with the IRF5 haplotype IFNG STAT1 STAT2 IFNAR2 IRF9 IFITM1 IFIT3 MX1 JAK1 TYK2 PMC3795344__F3 Schematic diagram illustrating a proposal for the involvement of Cdx2 during progression of cancers through the serrated pathway CDX2 CDKN2A BRAF PMC7281370__F2 Carbon metabolism in Synechocystis PCC 6803 FIG4 HEL107 RPE TNLG7C PMC12127422__F9 Oxy-inflammation mechanism, Nrf2 and NFKB signaling pathway and regulation of the NLRP3 inflammasome BAX IL10 NLRP3 KEAP1 COX2 BCL2 PMC6421779__F1 Canonical pathway for miRNA biogenesis RAN DGCR8 PAN2 PAN3 DROSHA PMC4073476__F3 Bile Acids are Nutrient Signaling Hormones NR1C1 PC IRS1 PMC4353379__F2 Proteins implicated in neurodegenerative diseases are involved in multiple steps of the miRNA biogenesis pathway FUS DGCR8 AGO1 DROSHA PMC2277398__F1 MAP kinase pathway analysis of the meta-modes MAX MAP3K7IP1 NEK6 PAK1 NLK TRAF6 DAO PMC2718437__F2A Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor B LTBP1 STAT3 SMAD9 SMAD1 DKFZp781O1323 TGFB1 SMAD2 SMAD4 MAPK9 RUNX2 TGFBR2 BAMBI INHBA FST NOG BMP4 MAPK1 THBS1 JUN SMAD6 FOS SKI SPP1 RUNX3 ENG CREBBP JAK1 LEF1 PMC3724417__F2 Signaling Mechanisms in Mammalian Myoblast Fusion KLF4 CDC42 KLF2 VASP TRIO SP1 NFATC2 FGF7B RELB GSK3B SMAD4 DOCK1 CTNNB1 COX2 PTGFR SRC GHR TEF PMC4569015__F2 Control of cell cycle transcription during G1 and S phases E2F2 C2 E2F8 E2F3 E2F6 CDK2 E2F7 PMC8143192__F3 Therapeutic Potential of HUMSCs in Female Reproductive Aging BAX HGF IGF1 MTOR PMC9164040__F3 Glance at the Molecules That Regulate Oligodendrocyte Myelination GPR37 SOX2 GIP PTEN ARHA FGF2 RHEB TSC2 NRG1 TSC1 FGFR1 RAB35 BDNF PMC10920255__F1 Macrophages participate in mediating inflammatory pain in GA NLRP3 TLR4 PMC9164040__F2 Glance at the Molecules That Regulate Oligodendrocyte Myelination TCF7L2 GSK3B PC CTNNB1 PMC5864197__F7 Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection ORAI3 SGK1 ELL MDM2 PMC8284850__F5 Intratumoural fibroblast heterogeneity in pDaC CD44 STAT3 CXCL12 STAT1 IL13 PDGFRA LIF SHH IRAK4 PMC10920255__F2 Gut bacteria and their metabolites can reach blood vessels, exert local effects in joints, modify macrophage-mediated inflammation and influence GA pain through breaches in the intestinal barrier NLRP3 TLR4 MYD88 PMC8400324__F1 Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer Chemoprevention and Intervention PTEN MTOR PMC6477749__F5 Re-analysis of 15 selected genes by KEGGpathway enrichment DBF4 RAD21 CDC20 CDK7 PCNA E2F4 SMAD4 CDK2 MDM2 SKP2 PMC4040894__F2 Heme biosynthesis SLC25A38 HMBS CPOX ABCB6 FECH ABCB10 UROD UROS PMC5700962__F11 Apoptosis pathway(red, up-regulated) BAX NGF BAD CAD CASP2 TRADD AIP ATM HRK FADD PMC5700962__F10 Thyroid hormones pathway (red, up-regulated) RHEB BAD PFKP PFKFB2 HIF1A MDM2 SRC GATA4 PMC5700962__F13 Wnt signaling pathway pathway(red, up-regulated) BAMBI SOST INVS SIAH1 ROCK2 APC SMAD4 SKP1 ARHA NLK PMC5700962__F12 Cell cycle pathway(red, up-regulated) DBF4 CDC20 PCNA SMC3 CD7 SMAD4 MYT1 SKP2 CDK7 E2F4 CDK2 CCL4 MDM2 PMC2891151__F1 TGFB ligands signal through the type I and type II TGFB receptors CDK6 SMAD6 CDK2 NODAL SMURF2 MYC CDK4 PMC12010877__F8 Growth status of tea plants under drought stress with and without the exogenous application of tea polyphenols MYB CAD PMC3233056__F7 Different expressed proteins indicated in glycolysis, TCA cycle, pentose phosphate pathway, nucleotide metabolism, amino acid metabolism, and cell wall development PTS NTM CIT PMC9100643__F3 Fermentative Indole Production via Bacterial Tryptophan Synthase Alpha Subunit and Plant Indole-3-Glycerol Phosphate Lyase Enzymes HEL107 PTS PMC9490947__F8 Pregabalin mitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury HMGB1 TLR4 PMC6524185__F7 Differential genes: the PI3K-Akt signaling pathway SYK EIF4B BAD MCL1 RBL2 PTEN CD19 MTOR EIF4E RHEB TSC2 PI3 MDM2 PMC5351668__F6 Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets PLAT HEL-S-62p CFI F10 PROCR KL VTN LYN C4A PROC PMC2890502__F2 The yeast MAPK signalling pathways deposited in KEGG CDC42 FAR1 SIT1 PMC4427840__F4 Pathway map of the Prtostaglandin E2 receptor signaling HRAS HGF COX1 CCR5 CREM CREB1 PMC5351668__F5 Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets LPL UBC HEL-S-28 FADS2 FABP4 ACADM RORA APOA2 ACADL PLTP CPT2 SLC27A4 CPT1A PMC4427840__F3 Pathway map of the histamine receptor response in dendritic cell CREM IRF8 CREB1 PMC5822798__F1 Activation of TLRs during heart failure TBK1 TNC HMGB1 TLR3 TLR4 TLR9 IRF3 TRAF6 MYD88 PMC11956240__F8 Interaction analysis of the differentially expressed proteins and metabolites involved in the top 10 enrichment pathways ASL CYP2E1 OTC SLCO1B1 AFMID DAO ABAT GLUD1 NAGS ALDH2 SHMT1 PC AADAT GPT UGT1A1 CYP1A2 GCDH UGT1A3 AOX1 UGT1A9 GOT2 CAD ABCB11 GPT2 KMO ARG1 HEL-S-30 ALDH3A2 SLC22A7 ME3 PCK2 ACACB AGMAT ALDH5A1 ACSM3 ME2 ALDH7A1 UGT2B4 SULT2A1 ALDH9A1 CYP2C9 CFTR CYP2C8 GLS2 CYP3A4 PYCR2 PMC11840736__F2 Epigenetic regulation-mediated disorders in dopamine transporter endocytosis: A novel mechanism for the pathogenesis of Parkinson's disease BDNF PICALM PMC8335696__F7 Effect of dapagliflozin on diabetic patients with cardiovascular disease via MAPK signalling pathway MAPK14 STAT3 MAP3K7IP1 SELE EGFR IRAK1 MAPK10 MAP2K1 VCAM1 GRB2 IRAK4 MYD88 PMC6043790__F1 Phospholipid synthesis pathways CDS1 PC INS PSD2 PMC4661888__F3 Gene expression analysis of thyroid hormone synthesis pathway DUOXA2 TG TSHR TPO DUOX2 PMC4573710__F12 Proposed model of HDAC10 regulation in G2/M transition HMGA2 HDAC10 CCNA2 PMC4531432__F1 Signaling pathway by which GUTK inhibited tumor metastasis in HCC (for abstract PS01-001) CDC42 RHO RAC1 PMC4637208__F4 Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts SCARB2 ACLY HEL107 CYCS GFPT1 SQSTM1 CCL5 ECI2 COX17 ACADM SUCLA2 ACOT9 PCYOX1 FH ACO2 HEL-S-133P FASN HEL-S-30 HEL-S-304 HEL-S-130P ME2 HEL-S-68p PFKP HEL-S-162eP TFEB DLD ENO1 HEL-S-87p PSAP M6PR PMC3891361__F8 Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA GFAP NOTCH1 HES5 PMC8980269__F1 PI3K/Akt/mTOR Signaling Pathway: Role in Esophageal Squamous Cell Carcinoma, Regulatory Mechanisms and Opportunities for Targeted Therapy NDRG2 SDCBP HEL-S-53e CCL3 SOX2 IQGAP1 IGFBPL1 GPX3 MTOR BMI1 MCM10 DNAJB6 RAP1A SLC39A6 MAEL PMC8980269__F2 PI3K/Akt/mTOR Signaling Pathway: Role in Esophageal Squamous Cell Carcinoma, Regulatory Mechanisms and Opportunities for Targeted Therapy RHEB MLST8 TSC2 PTEN DEPTOR PMC4637208__F2 Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts POR PTER UNG PMC9550351__F1 Emerging roles of microRNAs in the regulation of Toll-like receptor (TLR)-signaling TLR1 TAB3 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 PMC8699891__F5 Molecular Basis of Accelerated Aging with Immune Dysfunction-Mediated Inflammation (Inflamm-Aging) in Patients with Systemic Sclerosis BAX PMC8984994__F1 Advances in understanding of the innate immune response to human norovirus infection using organoid models IFNG STAT1 IFNGR2 IFNGR1 STAT2 IFNAR2 IFNAR1 TLR7 JAK1 TYK2 PMC9016280__F2 Mitochondria and Other Organelles in Neural Development and Their Potential as Therapeutic Targets in Neurodegenerative Diseases BAD MTOR SIRT1 PMC5499780__F1 Action of lenvatinib and everolimus.Notes: Lenvatinib inhibits RTKs on endothelial cell and cancer cell MTOR VHL PMC4643792__F3 Dietary phytochemical alters caste-associated gene expression in honey bees EGFR ZYX APP PMC9313263__F6 High Oxytocin Receptor Expression Linked to Increased Cell Migration and Reduced Survival in Patients with Triple-Negative Breast Cancer RPS6 EGF EGFR PMC5615248__F2 Regulation diagram LFNG NOTCH1 PMC3084093__F4 Proteins encoding the CAF and tumor stroma-associated genes from seven different epithelial tumors share common involvement in the MAPK signaling pathway and focal adhesion VWF ITGA4 SHC1 EGFR PDGFA PIK3R1 TGFBR1 CTNNB1 TGFBR2 ITGB1 ERBB2 TRAF2 PS1TP5BP1 PMC4473262__F4 Human Blood Metabolome-Transcriptome Interface PC PROC PMC3636692__F3 The VEGF-DLL4-Notch signaling pathway in angiogenic sprouts NRP1 NRP2 PMC9006576__F1 Emerging role of RNA sensors in tumor microenvironment and immunotherapy TBK1 MAVS TLR3 TLR8 NOD2 IRF3 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC5243832__F1 Activation and regulation of complement pathways relevant to Borrelia spp MASP1 CD59 FH C2 C1S MBP C9 C4A C4B_2 PMC6119098__F4 E-cadherin in Contact Inhibition and Cancer APC GSK3B CTNNB1 PMC6119098__F2 Regulation of the Hippo signaling pathway PATJ CRB3 AJUBA PALS1 NF2 AREG SRC CTNNB1 PMC11172217__F10 FGF5 promoting secondary hair follicle growth BAX HGF RNF43 NOTUM FGFR1 WAS DKK2 LEF1 CTNNB1 PMC10741648__F1 Reelin signaling pathway CRK DAB1 VLDLR CRKL SRC PMC5448101__F8 Ubiquitin editing in the Imd-signaling pathway DAP FADD PMC9128178__F7 Serial circulating tumor DNA monitoring of CDK4/6 inhibitors response in metastatic breast cancer CDK6 CDK15 ERBB2 MYC CCND1 CDK4 PMC7650809__F1 CTLA-4 pathway: (A) T cell activation in response to the tumor-associated antigen requires 2 signals CD80 PMC5789329__F5A Interplay between Selenium Levels and Replicative Senescence in WI-38 Human Fibroblasts: A Proteomic Approach PROK2 PMC9243315__F3 Paradoxical roles of miR-4295 in human cancer: Implications in pathogenesis and personalized medicine NPTX1 GPC5 BTG1 EGFR TP63 CTNNB1 RUNX3 PMC9243315__F2 Paradoxical roles of miR-4295 in human cancer: Implications in pathogenesis and personalized medicine BAX USP28 EGFR VEGFA RUNX3 CTNNB1 NPTX1 EREG GPC5 BTG1 SOS2 GC TP63 PC ERBB2 PMC10036653__F8 ER stress induces upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival TBX20 BMP2 PMC7847674__F2 Signal transduction mechanisms activated by ovarian steroid hormones on endometrial autophagy TF COX2 PGR ULK1 PMC4728676__F1 Molecular and cellular mode of action of energy disruptors TSC2 CAMKK2 PHGDH PTEN PMC4227529__F1 Metabolic shifts through the hexosamine biosynthesis pathway (HBP) and protein O-GlcNAcylation in cancer OGA OGT KRAS PMC3821664__F4 Biosynthetic pathway of major phospholipids in vascular endothelial tissue and mononuclear leukocytes TG HEL-S-5 PC PMC8649922__F1 Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy ACLY ACSS2 TG HMGCR CD36 FASN LDLR SIRT1 PMC5107940__F7 Proteomic adaptation of small intestinal mucosa in response to dietary protein limitation CLDN7 SLC7A7 LAT2 PMC9657665__F1 Cellular Senescence in Metabolic-Associated Kidney Disease: An Update CDK6 CDK2 SIRT1 CDK4 PMC3303935__F1 Toll-Like Receptors in Chronic Pain HMGB1 LTA CCL3 TLR9 CD14 TLR5 IRF3 CXCL10 CXCL8 MYD88 TLR3 TLR4 TLR7 IL1B PMC3259275__F2 ATM interaction with metabolic signaling pathways IGF1 ATM IGF1R GPX1 PMC10979625__F8 Brief figure summarizes the FGF2-FGFR1-p21 regulatory pathway in FGFR1 amplified ER + BC cells STAT3 FGFR1 CCND1 PMC5908125__F9 Glyoxalase 1 (Glo1) sustains the metastatic phenotype of prostate cancer cells via epithelial‐to‐mesenchymal transition (EMT) control: involvement of miR‐101, hydroimidazolone (MG‐H1), argpyrimidine (AP) and TGF‐B1/Smads signalling pathway HEL113 SMAD2 SMAD4 GLO1 PMC9223569__F1 Involvement of Ceramide Signalling in Radiation-Induced Tumour Vascular Effects and Vascular-Targeted Therapy CERK SMS tmp_locus_29 KDSR UGT8 PMC7520695__F3 Signaling pathway of IL-1B and IL-18 IL1R1 IL16 TRAF6 MYD88 PMC7520695__F2 Canonical pathway and activation mechanism of inflammasomes and outcomes in cancer GSDMD NLRP3 MYD88 PMC11725820__F1 Canonical type I IFN signaling pathway IFNK STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC7240857__F1 Different expression of MAPK8 in breast cancer samples to normal samples KRT18 AURKA EGF TGFA LEP CYP2E1 TM6SF2 PGR EGFR FGF21 PTEN ACACA MTOR INS MYC POR GNAS ALK MTTP RETN CHEK2 ATM AMH ABCG2 GPT CRP APOD FASN RBP4 VEGFA TNF KRAS HRAS NR1C1 ERBB2 APOB CDK2 HFE EP300 PMC5367651__F4 Diagrammatic scheme depicting potential survival pathway-related gene targets of the downregulated microRNAs and their signaling pathways in prostate cancer cells BAD RAF1 SOS1 PDGFA AKT3 GSK3B PTEN MTOR KRAS IKBKG FOXO1 NFKB1 CDKN1B CREBBP BCL2 GRB2 CCND1 PMC5367651__F3 Diagrammatic scheme depicting targeted p53 pathway-related genes by upregulated miRNAs in prostate tumor cells ZMAT3 CASP9 IGF1 PERP CYCS ATM PTEN BBC3 MDM2 PMAIP1 PMC6515203__F5 Main signaling pathways activated by growth factor signaling through receptor tyrosine kinases (RTK) and the importance of Mg2+ STAT3 TSC2 EGFR GRB2 SRC PMC5883056__F8 Compound 1G with the intermediate signaling pathway EGF SP1 EGFR SKP1 SKP2 PMC5883056__F7 Signal transduction Pathway analysis of the possible drug target FGR, ESR1 and GCRA and their localization ALDH2 FGF7A IGF1 FGFR1 PMC2677552__F3 PharmGKB pathway diagrams CYP2B6 CYP2C19 NR3A2 HSD17B1 CYP2C9 CYP3A4 PMC4209605__F1 Cutting the brakes and flooring the gas: how TMEPAI turns TGFB into a tumor promoter SMAD2 SMAD4 PTEN RHO MYC PMC5831574__F8 Analyses of the potential molecular mechanisms of EPB41L4A-AS2 by a bioinformatics-based method MAPK1 BMPR2 TAOK1 P2RY1 LRRC4 NFATC2 EPB41L4A RAPGEF6 THBS2 BAG4 NTRK2 MTOR TNF TGFBR1 XCR1 IGF1 ELMO1 ROCK1 SESN3 PMC7527411__F7 Proposed model of maternal combination exposed diet effects on cardiac network signaling in offspring PPARG GSK3B MTOR PMC9012636__F14 Study on the Mechanism of Üstikuddus Sherbiti in Ischemic Cerebrovascular Diseases: Based on Network Pharmacology TNC COL1A1 POLI GLA PTEN PMC7763629__F2 RTKs (EGFR) signal transduction and are a target site for small molecule and monoclonal antibody in glioma treatment EGFR PTEN MTOR PMC11998497__F9 PRRSV nsp5 protein interaction that accelerates the ubiquitination and degradation of Nrf2, thereby antagonizing its antiviral activity HMOX1 KEAP1 IRF9 NFKB1 NQO1 RELA IRF3 JAK1 TYK2 PMC8666006__F7 MLH1−/−-mediated cGAS activation and immunotherapy CGAS RAD51 PMC3326558__F8 Schematic illustrating estrogen-dependent regulation of miRNA (miR)-34b expression, its target genes and tumor growth CCND1 PMC4743853__F6 Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells HGF GRB2 PMC5754244__F7 MUC1-C INDUCES PD-L1 AND IMMUNE EVASION IN TRIPLE-NEGATIVE BREAST CANCER BMI1 MYC PMC2676316__F2 Isoprenoid Metabolism and the Pleiotropic Effects of Statins VAT1 ARHA RAC1 PMC1856251__F3 Molecular characterisation of non‐absorptive and absorptive enterocytes in human small intestine ATR CDC14B TGFB1 CDC20 PCNA CDC6 GSK3B MYT1 CCNA2 SKP2 PLK1 CCNH CCNB3 PTTG2 RB1 CDK6 CCND2 CHEK2 ATM MDM2 CCNB1 CDK4 CDAN1 APC MPEG1 PTTG1 CCNE2 MAD2L2 CDK2 EP300 UBE2F PMC6304355__F5 Distribution of target proteins of SBD on the compressed ‘NSCLC-pathway.’ Four pathways form the tubular NSCLC pathway CDC42 STAT3 BAX CSA2 EGF CASP9 ATR EGFR TNF COX2 MEI1 CASP3 MDM2 PMC7055240__F3 Cholesterol biosynthesis pathway and gene expression identified through RNA-seq ACLY HMGCR PMVK DHCR24 MVD AACS DHCR7 FDPS HSD17B7 MVK PMC4818393__F4 Integrative analysis of pathway features and the associated metabolites TH CTH HEL-S-87p PMC11353016__F2 Molecular drivers regulating hair follicle fate specification and the initiation of its growth PDGFA SHH FGF20 EDAR LEF1 CTNNB1 PMC9402976__F5 Review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer STAT3 SP1 TYK2 PMC7970325__F14 Statistically significantly enriched gene ontology (GO) molecular processes (GO-terms) identified for 871 differential genes between radioiodine resistant cancers and other thyroid cancer samples AKR1E2 SDF2L1 PLSCR4 SRPRA RNF175 RNF5 KLHDC3 AKR1C1 MIOX XBP1 HEL-S-99n PDIA5 FGF7A KCNK2 HEL-S-125m DNAJB2 HYOU1 RHBDL3 KCNAB1 AKR1C2 CTDSP2 ADGRG6 PMC9402976__F2 Review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer STAT3 CBL LYN GRB2 PMC7970325__F10 Reconstructed differential DNA repair molecular network for the comparison of Papillary cancer (PC) vs Follicular adenoma (FA) MPG RFC2 TERF2 NEIL2 NEIL3 MYT1 FANCL MYC FANCA FANCB PIDD1 FANCE FANCD2 CDKN2A BACH1 SERPINB5 CARM1 MUTYH RAD17 UNG HEL-S-1 MDM2 POLE PALB2 CREB1 MBD4 SMUG1 TDG DYRK2 POLL MSH6 RAD52 RAD50 CASP8 MSH2 SIAH1 RAD51 KAT5 MSH3 SP1 IRF9 PERP NBN ARFGEF2 AREG MDC1 XPC DDB2 ZMAT3 DDB1 LIG1 STEAP3 BRCA1 SESN1 ZNF350 CDC42 BRIP1 RAD51D PPM1D ATR FDXR CREB3 ERCC2 PCNA EGFR CD82 SFN PTEN CDKN2D XAB2 BLM TOP3A HIPK2 CARD16 PRH2 RAD9A ATM ATF4 POLR2A GPS2 HMGB1 DDX5 JUN FEN1 NEIL1 DROSHA XRCC3 HDAC1 RAD51C RAD54B PRKDC RPRM CREBBP EP300 TRAF2 PMC8645759__F8 Notch‐1 signaling promotes reattachment of suspended cancer cells by cdc42‐dependent microtentacles formation CDC42 NOTCH1 HDAC6 PMC10755271__F6 Network pharmacology and experimental evidence: MAPK signaling pathway is involved in the anti-asthma roles of Perilla frutescens leaf SYK RAF1 EGFR JAK3 MAPK8 GNB1 STAT1 BTK PDPK1 F2 IL2 ELANE KDR SRC HSP90AB1 MAPK1 JUN PLG PTPN11 ARG1 MMP9 VEGFA IL6 ARHA TNF RAC1 FOS FGF2 GNG2 HRAS IGF1 HEL-S-130P NFKB1 EP300 MAP2K1 GRB2 HEL-S-87p LCK PMC3972113__F13 Overexpression of miR-125a in Myelodysplastic Syndrome CD34+ Cells Modulates NFKB Activation and Enhances Erythroid Differentiation Arrest TF TLR1 TNFAIP3 TIRAP TRAF6 MYD88 PMC10502012__F5 Proposed mechanism for PHT1 mode of action TASL TLR9 TLR8 NOD2 TLR7 NOD1 MYD88 PMC11997203__F1 PI metabolism and the PI3K/AKT signaling pathway in cell dynamics INPP4A SYNJ1 PKP1 PIP4P1 IPMK PTEN INPP5E MTM1 OCRL PIKFYVE PMC4152414__F2 Coactivator dependent signaling regulates various biological functions, and deregulation causes diseases IL6 PMC8516775__F6 Bile acids increase intestinal marker expression via the FXR/SNAI2/miR-1 axis in the stomach KLF4 CDX2 MUC2 HDAC6 PMC11898953__F9 Lycorine hydrochloride Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3 and Erk Pathways STAT3 MTOR PMC11831486__F3 Tumor type‐specific protein network profile KRT18 RAF1 THBS2 AKT3 IL3RA GSK3B CTNND1 MARCKS VTN ADD2 MAP2 MTOR TNR FLNA KRT19 CTNND2 COL1A1 ITGA2 CSNK1A1 SRC THBS1 GAL COL1A2 GNG10 GNG4 FLNB GNB2 MAP1B TLN2 ARHA GNG8 HEL-S-34 COL2A1 HEL114 GNG2 PCK2 PREX1 TSC2 GSK3A ELMO1 FOXO3A CTNNA1 HNRNPC GNG7 LMNA PMC7697405__F2 Simplified schematic representation of the hyperactivated mammalian target of rapamycin (mTOR) signaling due to seizures RHEB TSC2 TSC1 MTOR PMC9020238__F2 Hepatitis C virus core protein: Not just a nucleocapsid building block, but an immunity and inflammation modulator HEL-S-92n TLR1 TRAF6 MYD88 PMC11997203__F5 PIPn signaling at the cytoskeleton in the regulation of cell dynamics CDC42 CEP164 PMC8355620__F4 Eccrine Sweat Gland and Its Regeneration: Current Status and Future Directions SMAD1 APC GSK3B LRP5 SMAD4 LRP6 MYC CTNNB1 KIF7 SUFU SHH SMO GRB2 EDARADD EDAR PMC6998363__F5 hsa-miR-4638-3p and hsa-miR-1273 g-3p Target Gene Network Map PPP1R12B SOS1 BMPR1A EGFR AKT3 SMAD2 SMAD4 IGF1R NODAL TNR MYLK3 FYN ACVR1B INHBE ROCK1 PDGFC PRKCA FLT1 SHC3 BMPR2 ACVR2B VAV3 TLN2 SMAD6 TGIF2 ITGB3 ID1 IGF1 PPP2R1B ERBB2 SMURF2 PMC9376100__F4 Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) GSTM2 FAS TNFAIP3 PMC9376100__F6 Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) STAT3 OSM CCR5 SMAD2 CCR2 SMAD4 RHO MTOR IL11RA CTNNB1 PMC4699200__F9 TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGFB Receptor Pathway in Human Aortic Endothelial Cells LPL ATF3 SMAD2 SMAD4 TGFBR1 PMC2670967__F2 Schematic (simplified) representation of enzymatic and metabolite components of the liver methionine metabolic pathway, and the influence of ethanol consumption HEL-S-182mP HEL-S-61p PMC9347431__F5 Coronavirus disease 2019 and pityriasis rosea: A review of the immunological connection CXCR3 STAT1 MAVS STAT2 IRF3 JAK1 CXCL10 TYK2 PMC4705964__F8 Working model for Gpr175 function as an enhancer of Hh signaling SUFU PTCH1 SMO PMC4788539__F7 Schematic model recapitulating the role Shoc2 plays in controlling ERK1/2 activity EGF SHOC2 LGALS3BP PMC1974887__F1 Endogenous Synthesis of Coenzyme Q in Eukaryotes COQ3 COQ2 COQ6 COQ5 PMC5858900__F1 Multifaceted Fanconi Anemia Signaling FANCE FANCD2 FANCM FAAP24 FANCA BLM FANCC PMC6315117__F4 Pathway analysis graph of G1/S checkpoint MAX BMI1 ATR SIN3A PAK1IP1 SMAD4 ATM MDM2 SUV39H1 PMC11599189__F2 Figure illustrates the various functions and molecular interactions of circFOXP1 in cellular processes STAT3 PTBP1 KDM5B MSC MTOR PMC3128904__F2 NOD-like receptor (NLR) family and inflammasome NOD2 NOD1 CARD9 PMC3128904__F1 Toll-like receptor (TLR) signaling pathway TBK1 TIRAP TLR9 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC12030433__F5 Carotenoid metabolic pathway POR CCS SI PMC6991631__F7 Proposed model of mifepristone for the treatment of adenomyosis CDH2 CDC2 CDK2 CXCR4 PMC3374974__F2 EphA Receptor Signaling – Complexity and Emerging Themes RHEB TSC2 RICTOR TSC1 EPHA2 PTEN GRB2 MTOR RAC1 PMC7384889__F4 Bone biology: insights from osteogenesis imperfecta and related rare fragility syndromes LRP5 WNT1 LRP6 CTNNB1 PMC5279903__F1 Molecular mechanisms of JNK1 and JNK2 in obesity-driven insulin resistance TSHB JUN NCOR1 FGF21 ATF2 IL6 IRS1 PMC9289261__F2 Neuroimmune Interaction in Chronic Pain: A Review on Immune Cells in Peripheral and Central Sensitization MYD88 PMC4135311__F2 Sirt1/AMPK/PGC1/PPAR signaling network NR1C1 FOXO1 PMC3385949__F1 FOXO proteins are involved in multiple signaling pathways that control cell proliferation, apoptosis, survival, and immune functions in response to external and internal stimuli FLT3 EGF NGF IGF1 IL3 EGFR MDM2 CTNNB1 PMC3573758__F2 Development of allergic inflammation SYK BTK FYN SPHK1 LYN GAB2 PMC3073290__F1 Models of how IFNB and GA activate PI3KD/Akt and MEK/ERK pathways to induce sIL-1Ra production in monocytes STAT1 IFNAR2 IFNAR1 PMC8958363__F7 Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages PDIA2 ATR RAD50 ATRIP UGGT1 SEC23A RAD51 USO1 HEL-S-269 BRCA2 MAN1B1 HEL-S-89n GANAB XBP1 KDELR1 DDB2 FANCD2 HEL-S-125m DNAJB9 DNAJB11 ATF4 B4GALT4 PMC9492418__F6 B-Cell Translocation Gene 2 Upregulation Is Associated with Favorable Prognosis in Lung Adenocarcinoma and Prolonged Patient Survival BAT2L R3HDM2 CNOT3 RELB NFKBIA IGF2BP2 PMC4253858__F1 EGFR signaling pathways and receptor cross-talk HGF AXL EGFR IGF1R MTOR PMC3462113__F1 Main metabolic reactions in central carbon metabolism.A) Xylose can be assimilated through two pathways: the fungal oxidoreductive pathway consisting of XR and XDH or the bacterial isomerization pathway via an XI RPE PIG59 PDC PC MDH2 CIT PMC2853973__F1 Kaposi's sarcoma-associated herpesvirus and innate immunity TBK1 TLR4 IRF3 CXCL10 PMC6665304__F6 DISC1 at the synapse PAK1 TNIK RAC1 DISC1 PMC6665304__F4 DISC1 regulates neurogenesis via Wnt/Beta-catenin signaling GSK3B DISC1 CTNNB1 PMC8469001__F6 LRP1B: A Giant Lost in Cancer Translation LRP1B APP PMC5355523__F7 Putative mechanism for the interaction between miRNA and the Ago2, Pum2, and REST proteins MOV10 HDAC1 REST AGO2 TET3 AGA HDAC2 PUM2 FMR1 PMC6863373__F2 Skeletal Muscle Atrophy: Discovery of Mechanisms and Potential Therapies SMOX ATF4 GADD45A PMC4633443__F1 Inflammasome axis NLRP3 CD14 NLRP2 IL1B PMC8999913__F6 Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering throughout the Endoplasmic Reticulum CERS5 SRM CERS2 PMC7328520__F6 nc886 and cancer STAT3 EIF2A MYC PMC9537379__F3 B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions CD80 GRAP GC AID IRS1 POU2AF1 PMC4122622__F1 Crosstalk of BMP and neurotrophin signaling in neurons SMURF1 PMC6354331__F5 Enrichment analysis with DAVID 6.8 of the associated genes for the 4 novel diseases and COPD POR PMC9537379__F5 B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions STAT3 STAT1 CD80 GRAP EBI3 PMC5133374__F4 Immune response_IL-17 signaling pathway IL17F IL17RC SP1 CCL7 CS JAK1 TRAF6 PMC5146691__F1 Implications of cell biological processes on innate immune signaling TLR4 CD14 AIM2 IRF1 IRF3 PMC6239905__F12 Metabolisms of SGG in seminiferous tubules: interrelationship between testicular germ cells and Sertoli cells PMC4216471__F4 The molecular cascade downstream of Nodal and Activin A signalling in EpiSCs SOX17 ACVR2B SNAI2 ACVR2A ID2 IFRD1 GSK3B NODAL ARHA MIXL1 ID3 CTNNB1 FOXH1 ACVR1B ACVR1 CRIPTO MMP2 ACVR1C GSC FOXA2 CXCR4 GATA4 CCND1 PMC7324512__F6 Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway LATS1 LATS2 VGLL3 AMOTL2 PMC2729380__F6 Expression and Functional Studies of Ubiquitin C-Terminal Hydrolase L1 Regulated Genes CEBPE TAPBP EGR1 PXN SP100 PML TSC22D3 SKI BIK HEL-117 EIF4E PMC5146691__F5 Biosynthetic pathway: nucleic acid detection from within the cytosol TBK1 CGAS MAVS TRAF5 AIM2 TRIM2 IFI16 TRAF6 TRAF2 PMC6307429__F3 Role of the NFKB pathway in the miR-155/SOCS1 axis in the immune system SOCS1 TLR4 TRAF6 MYD88 PMC4950325__F6 Schematic representation of the metabolic pathway leading to the activation of vitamin D3 to calcitriol VIT CYP2R1 CYP27B1 CYP24A1 CYP27A1 PMC7902901__F3 Merged network of Reactome pathways identified by all models (2.1 to 2.5) TYSND1 RUNX1 SHC1 BCR HEL-S-5 SOX2 ELL ACD RHO SET PMC7902901__F5 Induced regulatory network of smooth muscle cell contraction CALD1 HEL-S-273 SP1 ANXA6 SMAD2 SMAD4 SP2 PTEN FOXH1 SP3 CREBBP TLN1 NKX2-5 GATA4 PMC4804208__F6 Metabolic flux profiling of MDCK cells during growth and canine adenovirus vector production MAL PC CIT PMC4013140__F7 The Repressive Effect of miR-148a on TGF beta-SMADs Signal Pathway Is Involved in the Glabridin-Induced Inhibition of the Cancer Stem Cells-Like Properties in Hepatocellular Carcinoma Cells SMAD2 SMAD4 PMC7744575__F6 Schematic diagram illustrating the role of proteins encoded DEGs and DASGs and others on AMPA-receptor signaling and synaptic plasticity NAPA SYT7 SLC8A2 PMC5089864__F1 Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network GAL PGM2 PMC8531299__F1 FASN and the cell death decision circuitry controlled by the BCL-2 family ACLY BAX BAD FASN BOK BMF HRK BIK PMC5892715__F1 Breaking up with ATM H2AX RNF8 ATM MDC1 PMC8073244__F3 Viral Infection Modulates Mitochondrial Function MAVS IRF3 IRF7 PMC6193074__F10 Cardioprotection by AsIV through CaSR/IP3R pathway CASR BAD DLD GATA4 PMC11011684__F3 Gene Expression Patterns Associated with Survival in Glioblastoma PLCG1 COL1A2 EGFR NGFR PRKCA SMAD4 EP300 YBX1 RHO MTOR WIF1 CTNNB1 PMC6959132__F4 Pathway for signaling from p75–Nogo receptor complex to RhoA ROCK2 LINGO1 ARHA PMC3357504__F3 Translation initiation control relays signals to erythroid and granulocytic differentiation BCR MTOR EIF2A SET EIF4E PMC8432624__F2 Protein Arginine Methyltransferase 5 Functions via Interacting Proteins MTDH BTG2 COPRS CTNNB1 PMC6959132__F6 BDNF-signaling pathway mechanism PI3 NACA2 BDNF PMC3357504__F2 Translation initiation control during growth factor stimulation, cellular stress, and cellular physiology TSC2 TSC1 ELF2 PTEN MTOR EIF2A HNRNPK SET EIF4E PMC4011580__F6 SCFBeta-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway RBX1 NEDD4 SKP1 PTEN PMC8432624__F5 Protein Arginine Methyltransferase 5 Functions via Interacting Proteins SOX9 EGFR PTEN HEL-S-66 MTOR VEGFA STC1 CTNNB1 PMC2698574__F9 The VACV- and CPXV-stimulated PI3K/Akt pathway of biological relevance in spontaneously immortalized A31 and MEF cells BAD EIF4E PMC2877703__F1 Anabolic and catabolic pathways regulating skeletal muscle mass RHEB IGF1 MTOR ELF3 PMC8685516__F1 Ectodysplasin A/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases SMAD1 DKFZp781O1323 NKX2-3 TRAF3 TRAF6 EDAR CTNNB1 PMC8422731__F2 STAT3 pathway as a molecular target for resveratrol in breast cancer treatment STAT3 SIN3A SRC CCND1 PMC8422731__F1 STAT3 pathway as a molecular target for resveratrol in breast cancer treatment STAT3 EGF EGFR PMC4233289__F2 Proposed model for the regulation of mTOR signaling in conditions of overnutrition and the cardiorenal syndrome (CRS) RHEB TSC2 TSC1 IGF1 MTOR PMC20438__F5 Schematic diagram of possible Rad6-mediated metabolic pathways RAD18 REV1 PCNA PMC8528922__F3 Genes involved in the Taxol biosynthetic pathway TH IPP PMC5893168__F7 Signaling pathway predicted to be activated by the miRNA target predictor of IPA CXCR1 CAD COX2 VCAM1 SHE ARG2 MPO PMC2518924__F9 The CEBPD network GFAP MBP CEBPD FOS PMC5031950__F2 PCSK9 and apoB-containing lipoproteins metabolism PCSK9 APOE LDLR APOB PMC3502766__F5 Proposed metabolic pathway for the degradation of VFA and TCE inferred from the metaproteomic data tmp_locus_29 PSD PMC10931645__F2 Systematic Review of the Advances in the Study of T Lymphocyte Suppressor Receptors in HBV Infection: Potential Therapeutic Targets CD80 LAT APC TNF PMC10931645__F3 Systematic Review of the Advances in the Study of T Lymphocyte Suppressor Receptors in HBV Infection: Potential Therapeutic Targets CD226 CD48 CD244 CD2 CEACAM1 LTA APC CD96 TIGIT FGL1 CD160 BTLA LAG3 PMC5770609__F3 Crosstalk between the Hh and Wnt pathways forms regulatory loops SUFU APC SMO CTNNB1 GLI3 PMC5770609__F2 Wnt signaling pathway leads to the accumulation of Beta-catenin in nucleus APC GSK3B CTNNB1 PMC7806208__F5 Pathway schematics of pharmaceutical and ligand interventions of three signaling pathways known to be active in mammalian A549 cells TGFBR2 SMAD2 SMAD4 MDM2 TGFBR1 PMC6276890__F1 Canonical and non-canonical signaling pathways of the AhR CYP1A2 AHR CYP1B1 CYP1A1 PMC6803600__F2 Immunometabolic changes associated with DC maturation CD209 CD83 TBK1 NOS2 CD80 CD14 MTOR IL1B PMC5253683__F8 GA13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3Beta-NFATc1 signalling pathway HEL-S-62p CTSK NFATC1 ARHA TRAF6 GNA13 PMC7693142__F3 Methionine and folate cycle pathways involving PLP-, FAD- and B12-dependent enzymes CTH PMC4091098__F1 Heat shock protein-CD91 pathway mediates tumor immunosurveillance CD40 HEL-S-92n PMC5580204__F4 Signalling pathway in normal and hyperglycemia patients ROS1 CDK2 MMP9 CXCR4 PMC2788007__F1 Simplified representation of the complement cascade C2 C1R PMC6071544__F16 Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox SignalingReviewing Editors: Jerzy Beltowski, Joseph Burgoyne, Gabor Csanyi, Sergey Dikalov, Frank Krause, Anibal Vercesi, and Jeremy Ward TH FAS VASP FH C2 MAL CS HEL-S-26 CIT PMC8335696__F3 Effect of dapagliflozin on diabetic patients with cardiovascular disease via MAPK signalling pathway MAPK1 MAPK14 HEL-S-162eP EGFR MMP3 VCAM1 MAPK3 PMC8335696__F5 Effect of dapagliflozin on diabetic patients with cardiovascular disease via MAPK signalling pathway HEL-S-22 MAPK1 HEL-S-72p SELE EGFR TNF MAPK3 MAPK14 FLT4 F2 HEL-S-162eP F3 MMP3 MAPK10 MAP2K1 PMC7940178__F1 HCA2 triggers different downstream signaling pathway in different cell types TG BAD NLRP3 PMC4491684__F1 The Hedgehog signaling pathway mechanism SUFU PTCH1 KIF17 SMO PMC5797779__F1 Biochemical function and regulation of indolamine-2,3-dioxygenase 1 (IDO1) FOXA1 IFNG CD80 CTCF STAT5B IDO1 COCH AHR FOXA2 CTLA4 IDO2 PMC7147660__F1 PD-1/PD-L1 pathway and anti-PD-1/PD-L1 agents combination strategies in breast cancer HMGB1 CDK6 IDO1 CDK4 PMC12209598__F2 Redox regulation of metabolism and bioenergetics SYK DGAT1 NLRP3 BCR KEAP1 ATM MIF MTOR MPO PMC5817350__F2 Releases and signalling of IL-33 IL33 SIGIRR IRAK1 TRAF6 IRAK4 MYD88 PMC12209598__F4 Oxidative stress KEAP1 ULK1 ELF2 ERO1A EIF4E PMC3674189__F7 Estrogen receptor B ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis IGF1 PTEN BDNF PMC6020165__F3 Proteasome Inhibitors: Structure and Function JUN BIK PMC7397839__F1 Metabolic Role of PTEN in Insulin Signaling and Resistance PTEN GRB2 MTOR PMC8869711__F1 Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications TSC2 TSC1 PTEN MTOR GPX1 SELP PMC5341000__F6 Role of DHT- and EST-regulated proteins in energy metabolism HEL107 ECHS1 LETM1 CAD MRPL40 GLS HEL-S-67p GNPNAT1 HEXB HADHB SUCLG2 RIPK1 MDH2 GGH PSAP PMC4452412__F7 Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer CXCL12 SUFU SMO CXCR4 PMC5100792__F1 Isoprenoid biosynthetic pathways and enzymes in Arabidopsis IDI2 IPP IDI1 PMC7295567__F1 The insulin/IGF-1 signaling pathway in regulating FoxO3 activity is conserved between C PDPK1 FOXO3A PMC5351692__F1 Advances in sarcoma diagnostics and treatment EGF BAD GSK3A APC SHH SMO PTEN HIF1A MDM2 MTOR CTNNB1 PMC4686024__F10 Comparative Transcriptome Analysis in the Hepatopancreas Tissue of Pacific White Shrimp Litopenaeus vannamei Fed Different Lipid Sources at Low Salinity LPL UBC AQP7 UCP1 HEL-S-28 PLTP PMC9637487__F3 Conservation and divergence: Regulatory networks underlying reproductive branching in rice and maize OSER1 AGO2 SP3 SPI1 DST PMC9500642__F8 Lysophosphatidic Acid Promotes Epithelial–Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy LPA KLF5 PMC7096759__F1 Pathway map of pyrimidine metabolism depicting de novo, salvage, and catalytic pathways CAD GLS DHFR CMPK1 DPYD CMPK2 DUT DCTD ENTPD8 DHODH CTPS1 CDA DTYMK HEL74 SHMT1 DPYS APP UMPS TYMP PMC4404599__F3 Schematic overview of some of the most significant IPA-identified, canonical host response pathways CD40 CSA2 STAT2 IRF9 IFIT1 TAP1 IRF3 IRF7 IFI35 TRAF6 CCL2 HEL-S-99n STAT1 CXCR1 TRIM25 VCAM1 TAP2 IL8RB PMC9515447__F4 USP13 in physiology and diseases TBK1 STAT1 MAVS PMC7948473__F7 Proposed function and mechanism of ppGalNAc-T4 in breast cancer progression SNAI1 SMAD2 SMAD4 PMC9266916__F1 Neuroimmune Mechanisms Underlying Neuropathic Pain: The Potential Role of TNF-Alpha-Necroptosis Pathway RIPK3 TRADD MLKL RIPK1 TRAF2 FADD PMC4910876__F2 Mechanistic Target of Rapamycin: The grand conducTOR of metabolism and aging TSC2 IGF1 INSR OSR1 DEPTOR IRS1 PMC3316754__F5 Ingenuity pathway analysis was used to create a network of biologically relevant genes regulated in response to diet for comparisons control versus diet A, control versus diet B, and diet C versus diet B MYC THRA HUWE1 PMC5946470__F4 CD44-mediated downstream signaling pathways MMP14 HGF HEL-S-133P HIF1A MMP9 SRC RAC1 CTNNB1 PMC7274160__F4 Possible signaling pathways of hsa-miRNA-122-3p and hsa-miRNA-200a-5p enriched by the KEGG pathway analyses APC GSK3B GRB2 CTNNB1 PMC10968822__F3 Upregulation and downregulation of PD-L1 by YY1 through various factors STAT3 PTEN YY1 MTOR JAK1 PMC12113870__F2 Hesperidin action on the NFKB signaling pathway CAP2 LOX TRADD COX2 OTULIN TAB3 XDH CAP1 CYLD PMC7780193__F1 Cell Energy Metabolism and Hyaluronan Synthesis OGA OGT UGDH PMC7780193__F3 Cell Energy Metabolism and Hyaluronan Synthesis TGFB1 SP1 HAS2 YY1 TNF CREB1 SIRT1 IL1B PMC6493842__F1 Schematic representation of central histaminergic components HDC DAO PMC8865963__F1 Human genetics of SARS-CoV-2 infection and critical COVID-19 TBK1 MAVS STAT2 IRF3 IRF7 MYD88 STAT1 TLR3 IFNAR2 IFNAR1 TLR7 JAK1 TYK2 PMC5586499__F1 Metabolic Abnormalities and Oxidative Stress in Lupus IKZF1 PAX5 TRAF3 MTOR PMC12219042__F8 PKA-NFATs signaling pathway MYOG VEGFB NFATC2 C2 NFATC1 MEF2C PMC2573957__F1 Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination TIRAP TNFRSF4 TLR4 IRAK3 CD14 IRF3 IRAK2 TRAF6 LBP IRAK4 TNLG2B MYD88 PMC3582569__F2 Pathways regulated or induced by the presence of a specific sugar NAGA GAL RPIA XK HEL-S-162eP ENO1 FOS PMC5867295__F5 Processes of hypoxia and angiogenesis and the canonical fibroblast growth factor (FGF) signaling pathway and newly acquired insights into their relation to the development of the osteoarthritic (OA) chondrocyte hypertrophic phenotype NGF SOX9 HIF1A DDR2 RUNX2 COL2A1 PMC6714402__F5 DEGs involved in estrogen and prostaglandin signaling pathways JUN CREB3 MAPK9 MAPK14 GNAS HBEGF CREB3L2 CREB3L4 NFKB1 MMP2 ITPR2 ADCY6 SRC SHC3 PMC5867295__F4 MAP kinase and inflammatory signaling pathways ALPL SP1 CD36 IL16 CXCL1 ADAMTS5 COL10A1 RUNX2 SIRT1 COL2A1 PMC5237206__F2 Summary of three key signaling cascades that may mediate the link between inflammation and epileptogenesis TGFBR2 HMGB1 TLR4 IRF3 TRAF6 MYD88 TGFBR1 PMC5867295__F3 Canonical Ihh/PTHrP and Notch signaling pathways SIK3 IHH ADAMTS5 EZH2 COL10A1 VEGFA RUNX2 COL2A1 PTCH1 SMO ATF4 HES1 GLI3 PMC5867295__F2 Wnt- and TGFB superfamily signaling pathways SMAD1 ALPL DKFZp781O1323 GSK3B SMAD4 COL10A1 TCF4 ATF2 RUNX2 CTNNB1 SOX9 DKK1 GREM1 FRZB APC LRP5 LRP6 EZH2 AXIN2 ID1 SFRP1 MAP3K7IP1 MATN3 WNT3 SMURF2 LEF1 PMC5584596__F1 Duvelisib: A Phosphoinositide-3 Kinase D/G Inhibitor for Chronic Lymphocytic Leukemia BCR CD19 LYN PMC8532577__F2 Regulation on tumor metastasis by Raf kinase inhibitory protein: New insight with reactive oxygen species signaling STAT3 EGF HGF SRC NOTCH1 PMC1852551__F4 Multiple estrogen-regulated steps in the metabolisms of prostaglandin J2 and retinoic acid are implicated in estrogen-dependent growth of human uterine fibroids COX1 HEL-S-53e COX2 CRABP2 ANXA1 ALDH1A2 PMC2559911__F7 Model for the function of SHC-1 in IIS and JNK signaling SHC1 INS PMC11076791__F4 Proposed regulatory network KIF15 FOXA1 HEL23 SNAI1 SHH WNT1 NODAL GFI1 ELF3 PMC3236456__F2 Fungal cell wall pathogen-associated molecular patterns (PAMPs) and their host-pattern recognition receptors (PRRs) IL16 TLR9 PMC10854699__F2 Cachexia-related pathways in skeletal muscle: The mTOR (mechanistic Target of Rapamycin) signaling pathway, which is initiated by activated Akt and inhibits the phosphorylation of FoxO, facilitates the process of protein synthesis GDF8 IGF1 SMAD2 IGF1R MTOR TNF IRS1 PMC3236456__F3 Hypothetical model for a molecular chitinase response to chitin-containing pathogens or particles CHIT1 RELA IRF4 PMC4032603__F3 KIBRA in Hippo pathway FRMD6 LATS2 AMOT NF2 CIT PMC8835347__F7 Modulatory Effects of Alpha-Mangostin Mediated by SIRT1/3-FOXO3a Pathway in Oxidative Stress-Induced Neuronal Cells BAX SIRT1 PMC7248305__F2 Many functions of Ns1 and Ns2 STAT1 MAVS STAT2 IRF9 IL4 IRF7 TLR7 PMC7248305__F1 Interferon signaling pathway altered by Ns MAVS STAT2 IRF9 TANK IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 STAT1 TLR3 TLR7 JAK1 PMC9581396__F1 Editorial: Osteoporosis, sarcopenia and muscle-bone crosstalk in COPD STAT3 GDF8 NFATC1 CS PMC10893629__F4 Frequently altered signaling pathways in SCLC REST SOX2 EZH2 MYC LATS1 ME3 MOB1A MOBKL1A LATS2 ASCL1 SUFU PTCH1 CREBBP SHH BCL2 SMO EP300 DLL3 PMC4263734__F5 Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells RBX1 CXXC4 SIAH1 APC CER1 SMAD4 SKP1 NLK DKK2 LEF1 PMC4203741__F5 Long-HER Study: Clinical and Molecular Analysis of Patients with HER2+ Advanced Breast Cancer Who Become Long-Term Survivors with Trastuzumab-Based Therapy RHEB LPA TSC2 TSC1 PTEN PRKAA1 PMC7299730__F8 Serpinb6b regulation in uterine decidualization BMP2 MMP2 WNT4 MMP9 PMC2772137__F4 Temporal Profiling of Rat Transcriptomes in Retinol-Replenished Vitamin A-Deficient Testis HMGCS1 ACAT1 CYP17A1 ACAT2 HSD3B1 FDPS FDFT1 PMC9575553__F3 Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer TF KDM1A KDM5B KDM7A KDM2A MED1 PMC7151642__F3 Tumor Suppressive Roles of cGAS-STING CGAS RELA IRF3 SLC19A1 PMC7151642__F2 Independent functions cGAS and STING TBK1 CGAS RELA ATM IRF3 PMC2856900__F7 Moe and Rho1 function in apoptosis based on genetic, biochemical, and subcellular localization data TXN JUN FOS PMC7151642__F1 cGAS-STING signaling in immunity TBK1 RELA IRF3 TREX1 PMC5469704__F1 Stress-induced EGF Receptor Signaling Through STAT3 and Tumor Progression in Triple-Negative Breast Cancer MMP7 STAT3 EGFR MMP9 PMC3083942__F3 Proposed model for Syk in mediating oxidative stress-induced calcium release SYK BTK BLNK LYN PMC5377455__F7 Proteomic signature of muscle fibre hyperplasia in response to faba bean intake in grass carp RAN HEL-S-5 CPT2 PMC1434604__F1 Sites of action for reactive oxygen species in the regulation of the insulin signaling pathway PI3 PTEN GRB2 MTOR PMC10896898__F4 Mixed and gene only representations of the original KEGG pathway RASGRP4 PLCE1 PLCG1 PLCG2 RASGRP3 PRKCA PRKCB PMC10896898__F3 Recreated RAS signaling pathway CDC42 RASGRF1 TBK1 TIAM1 SOS1 RASSF1 RIN1 RHO GRB2 PMC6150107__F3 Role of HDACs and associated pathways involved in the processes of autophagy during the progression of DN HDAC3 ATG10 TSC2 ATG3 FOXO1 ULK1 HIF1A PMC5124539__F2 Role of Interleukin-18 in the Pathophysiology of Allergic Diseases IL13 IL4 FOXP3 TNF PMC7686079__F4 APC mediates biased signaling of PAR1 APC PC ARHA RAC1 PMC4905397__F1 Inhibition of tRNA synthetases restores glutathione from the effects of cystine deprivation in ferroptosis GPX4 ATF4 PMC9698586__F3 Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets TG RAN CD36 CPT1A PMC10985190__F2 Nerves promote tumour cell growth and survival The neural impact on tumors is mediated through sympathetic, parasympathetic, and sensory nerves, as indicated by solid lines in the diagram NGF EGFR ADRB2 METTL3 BDNF PMC6387630__F1 Representative pathway featuring multiple enzyme-/non-enzyme-assisted post-translational modifications (PTMs) that control cell-decision making RBX1 FYN KEAP1 PMC2893682__F7 Interaction scheme of Shh and activated Beta-catenin signaling SHH SMO NOTCH2 CTNNB1 PMC3587725__F1 Regulation of AMP gene expression through the VDR or FXR pathways IL1R1 NOD2 MYD88 PMC7568806__F5 Top network identified by ingenuity pathway analysis ANXA3 CENPA SLC44A1 TMPRSS3 PMC10985190__F4 Communication between tumor cells and nerves facilitates tumor perineural invasion ROBO3 CXCL12 SLIT2 SEMA3D CX3CR1 CX3CL1 PLXND1 CXCR4 CTNNB1 PMC7468437__F6 Gene network of “Rap1 signaling pathway” term enriched in both IgG4-RD tissue proteomic data and LSG transcriptomic dataset PDGFD THBS1 GNAO1 HGF PFN1 FYB1 SIPA1L3 EGFR NGFR AKT3 ITGA2B KITLG PRKCB FGF2 FGF7 SIPA1 PARD3 PDGFRA PLCB1 PLCB2 FLT1 DOCK4 MAP2K1 SIPA1L2 PMC6916202__F12 Major receptors and signaling pathways/proteins involved in atrophy and hypertrophy STAT3 FBXO40 IGF1 SMAD2 F3 GSK3B IGF1R TRAF3 MTOR TRAF2 IRS1 PMC4905226__F2 (See previous page) MRE11A ATM PARP1 PMC2592774__F1 TLR signalling pathways TBK1 SYK COX2 MAL IRAK1 IRF3 TRAF3 TRAF6 TNF MYD88 PMC8079327__F4 Dyslipidemia in breast cancer patients increases the risk of SAR-CoV-2 infection LTB LTA LOX PMC5867882__F2 Mammalian Hippo pathway FAT4 ECD AREG RHO TEAD4 LATS1 CD44 FRMD6 BIRC5 LATS2 TEAD2 TEAD3 SCRIB NF2 PMC6642550__F9 Peripheral and central compensatory mechanisms for impaired vagus nerve function during peripheral immune activation NTS IL18 IL1B PMC6232290__F2 IL-13 signaling mechanisms in the treatment of ulcerative colitis IL13 IL13RA1 IL4 JAK1 IL13RA2 PMC7981165__F2 PI3K/AKT-dominated signaling pathway regulates RUNX2 in PCa FOXO1 PTEN PMC7052942__F2 Verified signaling pathways of YWHAZ in HCC HEL-S-101 ATG3 AXL YWHAZ PMC6739099__F8 Identification of DEGs relevant to protein processing in the endoplasmic reticulum pathway SVIP RBX1 SEL1L ELF2 PAG1 ATF4 PMC7673349__F2 Hypoxia regulates CSCs with HIF-1 as the core CD44 HEL-S-53e SOX2 SHH CD47 PMC3577660__F8 Regulation of proteins translation in Jurkat cells EIF4B EIF3A MTOR ELF3 EIF4E PMC5490919__F1 Capsaicinoid biosynthetic pathway FAS CS PMC9531712__F1 Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition CDC42 ROR1 JUN APC ROR2 GSK3B LRP5 LRP6 ATF2 ARHA DAAM1 CTNNB1 PMC10917983__F3 Acrylamide promoted cell apoptosis via the miR-27a-5p-Btf3-ATM-p53 signaling pathway, adapted from Zhang et al BAX ATM BTF3 NDUFS8 PARP1 PMC10917983__F2 Biogenesis and mechanism of miRNAs DGCR8 PAN2 XRN1 AGO2 PAN3 DROSHA PMC8395761__F2 Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia TET2 GLS BCAT1 EZH2 MTOR PMC7917119__F9 Proposed model for the mechanism by which induced miR-2187 negatively regulates NFKB and IRF3 signaling expression by targeting TRAF6, thereby avoiding excessive inflammation and immune responses MAVS IRAK1 IRF3 MX1 ISG15 TRAF6 IRAK4 IL1B MYD88 PMC7999827__F4 Apoptosis and cell death pathway FAS PMC9284064__F2 Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target CXCR3 EGFR MYD88 PMC7606733__F5 Enrichment of the Hippo signaling pathway in CCA RASSF6 ID2 AFP PATJ AMOT APC SCRIB AREG MYC ID1 AXIN2 CTNNB1 PMC11551672__F1 Under the tumor microenvironment, abnormally activated wingless/integrated signaling pathway in cancer cells can be interpreted as an M2-tumor-associated macrophage polarization mediator APC GSK3B CTNNB1 PMC4747576__F6 Global MicroRNA Expression Profiling of Mouse Livers following Ischemia-Reperfusion Injury at Different Stages TRAF4 JUN TIRAP TICAM2 CD14 SIGIRR LBP PMC7460598__F4 Proposed mechanism by which LOXL2 causes fibrosis and cardiac dysfunction LOXL2 SMAD2 MTOR PMC6139299__F1 Schematic overview of light-regulated translational control pathways in the SCN VIP MTOR EIF4E PMC4137540__F2 Figures accompanying the sensitivity analysis C6 BAX HEL-S-62p C9 BCL2 PMC7937931__F4 ERBB2/VEGFA-AKT-PI3K-VEGFR signaling pathway and autocrine VEGFA signaling loop RHEB TSC2 TSC1 EGFR PTEN IGF1R MTOR VEGFA PMC4854551__F8 Proposed model for the involvement of the EIF2AK4-EIF2A-ATF4 pathway in autophagy response to AIEC infection in intestinal epithelial cells DKFZp762B153 EIF2AK4 ATG3 SQSTM1 ATF4 EIF2A PMC7937931__F3 Relationship between genes and their genetic functions TP73 EGF BAD PYCARD RASSF1 EGFR PTEN IGF1R MYC XBP1 MAPK3 POR RB1 SLIT2 PI3 NR3A2 MUC1 MMP2 ATM SRC CCND1 ABCB1 MGMT FOXA1 JUN APC PTGS2 VEGFA TFF3 ID1 GATA3 GRB7 ERBB2 BCL2 PMC5123285__F8 LRRC4 as a tumor suppressor in glioblastoma TF EGF LRRC4 EGFR PMC11598914__F2 Various interactions between RABV proteins and interferon signaling pathway TBK1 STAT1 STAT2 IRF9 PML IRF1 IRF3 IRF7 ISG15 PMC3965205__F1 Hypothetical mechanisms of tolerance within the TLR4 pathway IFNG TLR4 CD14 IRAK1 TRAF6 MYD88 PMC11012138__F3 Oxygen sensing and HIF pathway activation in embryonic neurogenesis EPO PAX6 ASCL2 DLX3 CTNNB1 PMC4403761__F1 S-nitrosylation in NFKB signaling EGF TRADD TLR4 TRAF6 TRAF2 MYD88 PMC5663315__F1 Schematic representation of the mTOR signaling pathway before discovery of TSC function RHEB STAT3 TSC2 GRB10 TSC1 FLCN HIF1A MTOR INS IRS1 PMC7432147__F4 Direct regulatory function of linc-ROR in various cancers SMAD2 MTOR DUSP7 PMC3180062__F8 Schematic Model of apoptotic signaling induced by targeting EphA2 gene by siRNA in MMC BAX CASP9 EPHA2 CASP3 FADD PMC5307469__F7 Role of ATF5 in the survival of B cells during stress PDX1 ATF5 ATF4 PMC3272682__F1 Recognition of Pathogenic Nucleic Acids by Patterns Recognition Receptors and Signaling TLR3 ELL TLR7 MYD88 PMC3630382__F10 "Cell Death and Survival, Cell Cycle, Cell-to-Cell Signaling and Interaction, Cellular Movement" Network AAR2 C19orf53 PHF6 ANKRD18A KRT3 PLBD2 FAM98A RPL26L1 ALG10 CALM1 KRT9 CACNB4 MYH7B MYH13 ZNF317 PMC10744776__F4 Anticancer properties of glycyrrhizinic acid in cervical cancer models BAX HMGB1 BAD PDC BCL2 CCND1 HES1 FADD PMC11509893__F2 Possible mechanisms involved in the therapeutic effect of acacetin on liver disease STAT3 TLR4 MTOR PMC4324923__F2 Current model of NLRP3 inflammasome activation in RPE RPE NLRP3 HEL-S-62p IL16 BRCC3 MYD88 PMC3060774__F3 Chromatin remodelling during development SOX2 MBD3 BPTF PMC7575966__F1 Enzymes and intermediate products of the heme synthesis pathway FECH UROD UROS PMC4589461__F1 Negative feedback regulation of bile acid metabolism: impact on liver metabolism and diseases MAFG CYP8B1 CYP7A1 FGFR4 CYP7B1 CYP27A1 PMC8048169__F7 Graphical summary of the investigated signaling pathways during osteogenic differentiation of DFCs GSK3B BMP2 CTNNB1 PMC11739504__F7 Summary illustration of this study TH SAG SMO KAT2B PMC10780960__F3 Comparative analysis of differentially methylated regions and differentially expressed genes in the metabolism pathways related to sink-source regulation EBF2 STS PMC12183848__F10 Photobiomodulation mitigates blood–brain barrier disruption in APP/PS1 mouse model of Alzheimer’s disease by activating the AMPK pathway BAX APP PMC4802898__F5 Mechanism of DQP efficacy on CHD rats LPL TG COX2 CD36 PMC3728701__F1 Musashi1 (Msi1)-dependent activation of Wnt and Notch pathways as well as of proliferation in the intestinal progenitors FRAT1 APC NUMB CTNNB1 PMC5114345__F4 Mechanotransduction through integrins and primary cilia SRC CTNNB1 PMC9667393__F2 Increased Pi availability on cellular signaling EGR1 FRS2 FOXC2 COX2 VEGFA PMC8787203__F5 Turning the Knobs: The Impact of Post-translational Modifications on Carbon Metabolism TF SNRK HEL-S-162eP PMC6087715__F1 JAK–STAT signaling and core cancer pathways STAT3 PTEN CTNNB1 PMC11563827__F5 Peri-implantitis involving multiple signaling pathways WNT3A TLR4 WNT1 TRAF6 MYD88 PMC9610910__F2 Protein O-GlcNAcylation in Metabolic Modulation of Skeletal Muscle: A Bright but Long Way to Go HEL107 F2 GNAL HEL-S-11 PMC10854678__F9 Arf6 signaling pathway, the inhibitors used in this study, and a model of MuLV Gag release PLD2 ARF6 MTOR CD63 PMC4799985__F1 Microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia TIRAP TLR4 CD14 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC4203530__F1 Dark side of Toll-like receptor signaling STAT3 EGF HMGB1 TREM1 TGFB1 HGF HDC TLR9 SRC MYD88 PMC6549028__F1 Emerging roles of inflammasome‐dependent cytokines in cancer development HMGB1 COIL AIM2 RHO IL1B PMC8787203__F3 Turning the Knobs: The Impact of Post-translational Modifications on Carbon Metabolism ATG101 PMC12067419__F8 Possible underlying mechanism of AR inhibitors in the treatment of PAH NOTCH3 HES5 PMC7016711__F4 Central carbon metabolism FH GLS CYP2E1 MAL HIF1A CS PDK3 PHGDH HEL-S-162eP PC ENO1 PSPH CIT PMC3397358__F1 Viral genes and the activation of apoptosis BAX FAS RNASEL EIF2A PMC4150436__F2 miRNAs involved in angiogenic process HGS SUFU PIK3R2 PTEN MTOR VEGFA CD47 PMC3199545__F1 Schematic diagram illustrating some of the major abnormalities related to sensitized D1R-signaling and associated to LID PDYN ARC BDNF PMC8938720__F6 Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway STAT3 HMFT1766 ENG SMAD1 DKFZp781O1323 SMAD4 ANGPT2 PMC4702938__F3 Example of the allosteric network ‘Calcium signaling pathway’ PLN NOS2 TNNC1 HTR7 PPIF ORAI1 STIM1 SPHK1 CHRNA7 SLC8A1 ATP2A1 GNAS MYLK PLCG1 CALM1 MCU RYR1 ADCY1 CAMK2G PMC9589424__F3 TSH−SPP1/TRB−TSH positive feedback loop mediates fat deposition of hepatocyte: Crosstalk between thyroid and liver BAD INA PFKFB2 MDM2 DAO PMC3739442__F1 Accelerated aging model in HIV infection ICE1 PMC6350575__F2 Differential gene expression involved in the KEGG pathway regulated by TRF treatment, i.e., (a) cell cycle, (b) p53 signalling pathway, (c) FoxO signalling pathway, (d) Wnt signalling pathway, and (e) ErbB signalling pathway RBX1 JUN ERBB2 MYC NRG4 PMC6190739__F3 DNA hypermethylation, histone demethylases and histone deacetylases effect on the metabolic enzymes expression involved in glycolysis and glutaminolysis GLS HEL-S-133P HK2 SIRT4 KDM3A PTEN MTOR MYC VHL SIRT3 FBP1 KDM4C SIRT6 PMC5501999__F2 Abnormal kynurenine pathway and atherogenesis TG APOE LDLR VCAM1 CD68 PMC6294838__F7 Signaling pathway of defensins and interleukins gene expression is regulated by PBA in porcine intestinal epithelial cells TLR4 EGFR PMC9419495__F2 Whole Exome Sequencing in Patients With Ectopic Posterior Pituitary CDH2 HESX1 RIPPLY2 MESP2 TBX6 ROBO1 FGF10 NOTCH2 CTNNB1 PROP1 OTX2 SHH LHX3 PMC4253421__F7 LGR5 promotes the proliferation and tumor formation of cervical cancer cells through the Wnt/Beta-catenin signaling pathway APC GSK3B LRP5 LRP6 GPR49 CCND1 CTNNB1 PMC5704268__F6 Schematic representing the in-depth molecular mechanism of the neuroprotective effect of DZ BCL2 MTOR PMC6811524__F4 Canonical Wnt signaling manipulation during Rickettsia spp DKK1 APC GSK3B CTNNB1 PMC11387478__F0 HIRI is a thorny problem after liver surgery such as liver transplantation PTGS2 MERTK PMC6811524__F3 Canonical Wnt signaling manipulation during bacterial infection of epithelial cells MMP7 OLFM4 APC GSK3B BCL2 IL6 CCND1 CTNNB1 PMC7588841__F2 Cancer Stem Cell Niche KLF4 STAT3 EGF SMAD1 DKFZp781O1323 GSK3B CR2 RHO MTOR CR1 CDX2 SALL4 TBX3 ZFP42 GATA6 SRC LIF APC SOX2 RIF1 CRK TCF3 FOXD3 GRB2 GATA4 PMC6811524__F6 Canonical and non-canonical Wnt signaling manipulation by pathogens occupying an extracellular niche NFIB APC CTNNB1 PMC10138520__F5 Lipid metabolic reprogramming in TNBC FAS SMAD2 TWIST2 AKR1B1 TWIST1 PMC3913083__F1 Signaling pathways involved in the control of skeletal muscle atrophy and hypertrophy ALK IGF1 GDF11 EIF3F SMAD2 ATF2 MTOR IRS1 PMC6811524__F5 Canonical and non-canonical Wnt signaling manipulation during E CDC42 DAZAP2 KDM6B IRF2BP2 ARID1B APC GSK3B ARHA MTOR DAAM1 CTNNB1 PMC6811524__F2 Non-canonical/Beta-catenin-independent Wnt signaling pathways CDC42 ARHA DAAM1 PMC6811524__F1 Canonical/Beta-catenin-dependent Wnt signaling MMP7 APC GSK3B MYC CCND1 CTNNB1 PMC4189729__F1 Synthetic lethality as a therapeutic strategy for the treatment of MMR-deficient cancers MSH6 MSH2 MSH3 PMC3553670__F3 Signal transduction pathways and activation of the innate immune response TIRAP TLR3 MAL TLR8 LDLR TLR7 MYD88 PMC6594416__F2 Autophagy signaling pathway BAX FAS MLKL ULK1 ATG14 MTOR ATG101 RIPK3 ATG10 ATG12 TLR4 BCL2 ATG5 FADD PMC3285363__F7 Hypothetical scheme illustrating a possible mechanism of mLDL-mediated regulation of C3 expression and secretion by human macrophages HEL-S-62p TLR4 CD14 PMC6242766__F2 Animal Models to Study Bile Acid Metabolism CYP8B1 CYP7B1 CYP27A1 PMC3316934__F4 Significant differences in mRNA expression were seen for genes involved in the JNK signaling pathway between tumors arising in different CNS locations CRK MAP3K7IP1 TRADD CRKL NFATC1 ATF2 GRB2 TRAF2 IRS1 LCK FADD PMC6594416__F3 Endoplasmic reticulum (ER) stress signaling ATF4 EIF2A TRAF2 PMC3159175__F1 Multiple TYRO3-activated pathways signaling pathways converge with transcription or activation of MITF (reproduced from Mitra et al ()), an oncogenic transcription factor often dysregulated in malignant melanoma PAX3 TYRO3 SOX10 PMC87143__F6 E2F gene regulatory pathway DBF4 RAD51 CDC20 PCNA E2F2 CDC6 ORC1L CCNA2 MCM7 E2F3 MCM3 CDK2 MCM5 MCM6 MCM2 CDK4 PMC10138520__F3 Glycolysis and its relationship with other metabolic pathways in TNBC FAS PHGDH PSAT1 PMC3402511__F4 Novel MicroRNAs Differentially Expressed during Aging in the Mouse Brain TSC2 TSC1 IGF1 INSR FOXO1 PDPK1 PTEN PDK2 MTOR INS PMC10138520__F2 Compounds secreted by adipocytes support tumor growth, angiogenesis and metastasis STAT3 HGF IGF1 VEGFA MMP11 PMC4717906__F2 Pathway and Network Analysis of Cancer Genomes LRIG1 EGF PTK6 SHC1 SOS1 EGFR CRIM1 PMC4189590__F7 Proposed model of the mechanisms involved in PAF-mediated EGFR transactivation in SKOV-3 ovarian cancer cells HBEGF EGFR SRC PMC12187804__F2 TANs promoting the growth, proliferation and metastasis of breast cancer LIN28B ALOX5 TLR4 LCN2 MMP9 VEGFA CTSC PMC4140012__F7 (Summary illustration): Three USPs regulate Imd activation or stability and downstream signalling USP36 USP2 USP34 REL PMC6521226__F5 Circadian rhythm pathway identified as one of the significant pathways by the IPA VIP AVP PMC4505489__F8 NAMPT inhibition leads to alterations of different metabolic pathways in cancer cells FH NAMPT PSPH PMC7813845__F4 BRD4 in regulating the STING1 pathway in antiviral immunity BRD4 TBK1 CGAS NFKB1 IRF3 MITA PMC7813845__F3 Role BRD4 in regulating the NLRP3 pathway in inflammation and pyroptosis BRD4 PYCARD NLRP3 RELA IL18 IL1B PMC7813845__F2 Role BRD4 in regulating the NFKB pathway in inflammation and immunity BRD4 TLR1 TLR3 TLR4 NFKB1 IKBKB RELA NFKBIA TLR9 CHUK TLR7 IKBKG PMC7025494__F1 Cytoskeletal Regulation of the Hippo pathway in Drosophila and Mammals AMOT AJUBA PMC12193713__F5 Relationship between key genes in the biosynthetic pathways of amino acids and their derivatives and the synthesis of metabolites ACLY ASL OTC CS MINPP1 SDHA NAGS DLAT PIG59 OGDH PHGDH HEL-S-162eP PDC HEL-S-5 BHMT2 PSAT1 NR1A2 PSPH GPT PMC4791423__F3 Crosstalk between the TLR signaling pathway and the Notch pathway TNF HES1 PMC9268066__F1 Progress and Prospects of Non-Canonical NFKB Signaling Pathway in the Regulation of Liver Diseases LTB CD40 LTA LTBR RELB TRAF3 TRAF2 PMC7374090__F5 Development and implementation of the SUM breast cancer cell line functional genomics knowledge base RASSF6 BIRC5 AFP PATJ AMOT APC SMAD4 SCRIB CTNNB1 PMC9434367__F1 Inside the Noonan “universe”: Literature review on growth, GH/IGF axis and rhGH treatment: Facts and concerns RAF1 SOS1 BRAF PTPN11 CS KRAS HRAS CBL NF1 HEL-S-80p SHOC2 SOS2 RIT1 GRB2 PMC7374090__F3 Development and implementation of the SUM breast cancer cell line functional genomics knowledge base CDC26 MAFK ATR ANAPC10 CDC14B CDC20 PCNA BUB1B SMC3 CDC23 MAL ANAPC2 SMC1A PLK1 E2F5 CCNB3 RBX1 RAD21 MCM7 MCM2 PMC8714916__F1 Visualizing Cancer Cell Metabolic Dynamics Regulated With Aromatic Amino Acids Using DO-SRS and 2PEF Microscopy FAS FOXO1 TFEB PMC8833689__F2 Obscure Potential of AHNAK2 TF PRX AHNAK2 PTEN AHNAK CTNNB1 PMC5927620__F4 Metabolic pathways dysregulated in the context of disease MAL FUOM CIT PMC4504792__F6 Methylene blue-induced neuronal protective mechanism against hypoxiareoxygenation stress EPO MB MTOR PMC6175538__F5 Phosphoproteomic pathway analysis of heat stress induced MET signaling CDC42 STAT3 HGF PXN COX2 PAK1 CRKL ATF2 GRB2 UNK PMC8946769__F2 NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation HMOX1 TXN KEAP1 GCLM NQO1 GCLC SLC7A11 HEL-75 PMC3661706__F1 Association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer TIRAP TLR4 CD14 TANK SIGIRR IRF3 TRAF3 TRAF6 LBP MYD88 PMC2149843__F1 A pro-adhesive PPARGamma-mediated chemokine receptor switch, CCR2→CX3CR1, in atherosclerosis CX3CR1 CX3CL1 CCR2 PMC2410087__F1 Example of EGFR-mediated signaling changes, a commonly disrupted pathway in lung cancer CDC42 STAT3 EGF TNK2 JUN SHC1 CTNND1 FOS RAC1 MAPK3 HRAS STAT1 GRB7 GRB10 PAF1 SHOC2 PAK1 MAPK7 NRAS JAK1 PMC11619119__F2 Key IFN signaling pathway targets disrupted by HBV components SOCS1 TBK1 MAVS IFIT1 IRAK1 SOCS3 TRAF3 IRAK4 MYD88 STAT1 ZBP1 TLR4 SP3 TLR8 MX2 MX1 TLR7 ISG15 SP1 STAT2 RNASEL SP2 IRF3 IRF7 TLR3 IFNAR2 IFNAR1 JAK1 TYK2 PMC10273736__F5 Review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies TH COX2 TNF PMC6121355__F2 Multiple potential neuroprotective mechanisms in Shh signaling pathway BAX NGF SHH SMO BDNF IL1B PMC3742659__F2 Learning and memory: an emergent property of cell motility EGF SEMA3A EGFR PTEN ARHA MTOR PMC10273736__F3 Review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies MAX ECSIT JUND FAS TRADD CD14 HP NLK TNF CDC25B MYD88 PMC10273736__F2 Review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies SYK EGF LTA TIRAP LAT CD14 IRAK1 BLNK TRAF3 TRAF6 IRAK4 MYD88 LTB CNTF NGF TRIM25 BCR COX2 TLR4 ATM TRAF2 EDAR CYLD LBP PMC3264680__F3 Diagram of IGF/INSR/IGF1R signaling pathway IGF2R IGF1 IGF1R INS IGF2 PMC4410894__F3 Signaling pathways involved in pluripotency IGF1 APC LIF SOX2 GSK3B NODAL CTNNB1 PMC12004712__F9 KEGG “Cell Adhesion Molecules” pathwayKEGG “Cell Adhesion Molecules (Immune System section)” pathway highlighting the associated a) AC and b) VC contrast DEGs CD226 CD40 TH CD2 ESAM SELL SELE APC PTPRC POLI CD99 CD34 SPN ITGAM PTPRO COIL SELP CD6 PMC4277084__F3 PPAR signalling pathway LPL UBC AQP7 UCP1 HEL-S-28 PLTP PMC5721794__F18 Working hypothesis regarding the mechanism by which SDF‐1A (stromal cell‐derived factor 1A) stimulates cell proliferation DPP4 SRC CXCR4 CCND1 PMC9101816__F5 Non-Cytokine Protein Profile of the Mesenchymal Stem Cell Secretome That Regulates the Androgen Production Pathway CFL2 EGF CYP17A1 AXL PXN EGFR PGLYRP2 COL3A1 FGF2 VCAN AHSG CLU CYP11A1 KIAA1608 MMP2 APP MAP2K1 HP SRC PS1TP5BP1 PMC4684904__F3 Integrated, multi-cohort analysis identifies conserved transcriptional signatures across multiple respiratory viruses IFI6 LGALS3BP IFIH1 IRF7 DHX58 RTP4 PARP12 ZBP1 CDKN1A HERC6 MX1 ISG15 EIF2AK2 PMC10978763__F3 Polyphenols and immunomodulation: a mitochondria-centered multi-modal approach STAT3 FAS NLRP3 BCR COX2 AHR MTOR PMC9352453__F1 Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19 ACE2 PMC11034561__F3 Progress in the Study of the Role and Mechanism of HTRA1 in Diseases Related to Vascular Abnormalities EGF EGR1 HEY2 EGFR DLL4 HTRA1 PMC11034561__F2 HTRA1 can affect BrM morphology through cleavage of ECM (Fibronection) TGFB1 SMAD2 VTN HTRA1 CD47 GDF6 PMC5309409__F1 Nucleotide excision repair (NER) pathway ERCC1 XPA XPC PMC6174665__F2 IFNG/STAT1 and IL-6/STAT3 or IL-6/NF-IL6 signaling pathway IFNG STAT3 STAT1 PMC4478474__F2 Gene co-expression network of the 48 genes in the peroxisome proliferator-activated receptor pathway based on their expression values PPARG ACOX1 ACSL6 ACSL5 FACL4 HEL-S-28 FADS2 SLC27A1 NR1C1 AQP7 PLIN1 PLTP CPT2 RXRB PMC3318588__F8 Subnetwork of functional interactions of ESRP-target networks GIT2 EPHB4 ARHGAP1 GUSB RAPGEF2 ATP2B4 MYO6 YAP1 PMC7894481__F8 Scheme representing the effect of FGF2 on the activity of connexin hemichannels and consequences on ATP release and proliferation of cultured tanycytes FGFR1 NPY FGF2 PMC12102912__F9 Mechanistic illustration: ITGB3-knockdown enhances osteogenic differentiation and radiosensitizes osteosarcoma cells via JNK/c-JUN/RUNX2 pathway activation BAX ITGB3 RUNX2 ITGA2B ITGAV PMC4506991__F7 Proposed mechanisms of bilirubin modulation of TLR4 signaling TLR4 AHR CYP1A1 MYD88 PMC4426976__F1 Can we safely target the WNT pathway? BCL9 GSK3B LRP5 LRP6 CTNNB1 PMC3022256__F2 Patterning the DV axis in Drosophila and Tribolium EGF TGFA RHO PMC8614623__F7 Huangkui Capsule in Combination with Leflunomide Improves Immunoglobulin A Nephropathy by Inhibiting the TGFB1/Smad3 Signaling Pathway SMAD2 SMAD4 PMC9687800__F1 Emerging Role of YAP and the Hippo Pathway in Prostate Cancer LATS1 VGLL4 PMC4426976__F2 Can we safely target the WNT pathway? RNF43 LRP5 ZNRF3 LRP6 GPR49 CTNNB1 PMC7432388__F2 Top two networks based on ingenuity pathway analysis (IPA) showing interactions between the controls and the case CACNB1 MGA SHOX2 MSC SNCA LHX3 RUNX2 PITX2 RXFP2 PMC11621763__F4 C-Myc/Max signaling pathway MAX BAX MYC FADD PMC8541931__F2 Molecular pathways underlying homotypic circulating tumor cell (CTC) cluster formation CD44 CDK6 EGFR HIF1A PMC6382702__F8 Clavulanic acid biosynthesis is regulated by the TCS CagRS CAD GCA PMC4975672__F1 Xenobiotic Receptor Activation: Direct vs. Indirect EGF EGFR GRIP1 PMC7465958__F2 RasGRF2 as an effector of AnxA6-mediated TNBC cell growth and motility CDC42 ANXA6 EGFR RASGRF2 PMC8575642__F1 Irisin Acts via the PGC-1A and BDNF Pathway to Improve Depression-like Behavior FNDC5 UCP1 BDNF PMC1533821__F2 Recognition of pathogens by cytosolic PRRs IRF3 NOD1 FADD PMC7016605__F1 The role of the RhoA-ROCK pathway in the pathogenesis of TBI EPHB3 LINGO1 PTEN RHO PMC4635001__F1 Structural Characterisation of FabG from Yersinia pestis, a Key Component of Bacterial Fatty Acid Synthesis FAS FH FBL FASN FES ARG1 PMC2882122__F4 Selection of expression patterns and activities of members of the cadherin superfamily in cancer CDH2 CDH10 FAT4 PCDHY APC DCHS1 PMC3414384__F1 Actin cytoskeleton as a sensor and mediator of apoptosis BAX BAD BMF HRK APAF1 BIK FADD PMC12014580__F1 Cholesterol structure, synthesis, and metabolism LPL HMGCR SQLE APOE LDLR MVD FDPS PMC3092286__F1 Nonlinear signaling through the PI3K-Akt pathway RHEB PTEN PMC4176492__F2 Role of cell cycle regulators in the cellular dormancy (“intrinsic dormancy”) mechanism E2F4 APC SKP2 PMC5382276__F7 A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer BRD4 NFKB1 CD47 PMC7982813__F2 Cellular mechanisms and molecular pathways in Müllerian duct development TF SMAD1 DKFZp781O1323 WNT9B GATA3 FGFR2 DMRT1 EMX2 PAX2 WNT7A WNT4 DACH1 GRB2 PMC6545921__F5 Type I IFN plays an integral role in macrophage regulation of Mmp28 following stimulation with PAMP TIRAP STAT2 CD14 IRF7 CXCL10 MYD88 STAT1 TLR3 TLR4 CCL4 JAK1 TYK2 MMP28 PMC7719714__F2 O-GlcNAcylation induces the DNA damage response and proliferation in stem cells OGA OGT ATR H2AX ATM PMC1964795__F5 INHIBITION OF MAPK AND STIMULATION OF AKT KINASE SIGNALING PATHWAYS: TWO APPROACHES WITH THERAPEUTIC POTENTIAL IN THE TREATMENT OF NEURODEGENERATIVE DISEASE RHEB BAX TSC2 BAD TSC1 MDM2 PMC5528622__F3 Resistance to targeted therapies in melanoma EGFR BRAF NRAS PTEN IGF1R PMC3680226__F6 Analysis and Prediction of Pathways in HeLa Cells by Integrating Biological Levels of Organization with Systems-Biology Approaches ATM ATF2 ARHA RAC1 PMC7719714__F1 Cellular response to stress via O-GlcNAc-dependent epigenetic regulation OGA ME3 OGT TRIM28 H2AX EZH2 PMC7509237__F6 Model highlighting the identified dual role of GPS2 during human adipocyte differentiation LPL ABCG1 BMP4 GPS2 PMC3806458__F1 Scheme of the biochemical pathways leading to carotenoids and other terpenoids IPP PMC4366044__F4 Molecular Interaction of a Kinase Inhibitor Midostaurin with Anticancer Drug Targets, S100A8 and EGFR: Transcriptional Profiling and Molecular Docking Study for Kidney Cancer Therapeutics CRK ARHH VASP RAD1 ITGA4 OCA2 PXN ARHA PMC1682017__F4 Effect of increased HER2 expression on phosphorylation sites within the EGFR signaling network EGF PXN HRG PMC6280363__F3 Crosstalk between surface TLRs and dysregulated metabolic factors in diabetes TLR4 SIRT1 IL1B PMC7260123__F9 BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer IGF1 KEAP1 GRB2 MTOR PMC5020118__F1 Innate immune dysfunction in rosacea KLK5 TRPA1 TRPV1 FGF2 PMC7476100__F7 Mechanistic model to show how MEQ inhibits triple-negative breast cancer (TNBC) angiogenesis by regulating the MTA2/SerRS/VEGFA axis MAX MTA2 SIRT2 VEGFA PMC6014302__F4 GO enrichment of the highest score sub-modules RPS15A MRPL11 EIF1AY RPS5 RPLP0 RPS14 RPS19 RPL36AL SSR1 RPS27A MRPS10 SEC11A NHP2L1 SEC61B ETF1 EIF3G RPL26L1 RPS3 RPL27 RPL9 EEF1A1 RPS9 PMC3266027__F1 Activation of EGFR signaling in non-small-cell lung cancer (NSCLC) can occur via disruption of several different components at multiple levels of the pathway EGF BAD TGFA PTEN KRAS PMC7998891__F6 Molecular components of BCG-driven inflammation in bladder cancer microenvironment CXCL9 CXCR3 CCL22 CXCR1 COX2 IDO1 CCR4 CXCL10 CXCL8 PMC3561014__F2 Adjustments in root metabolism promote acclimation to deficiency C2 CS PMC8995458__F5 Fibroblast growth factor 21 reverses high‐fat diet‐induced impairment of vascular function via the anti‐oxidative pathway in ApoE knockout mice FGF21 APOE PMC7768820__F4 Underlying mechanism of Paeonia lactiflora P CASP9 ADORA2A DRD1 CASP8 DRD2 SLC6A3 CASP3 BCL2 IL6 PTGS2 TNF PMC6990892__F13 Pathway signaling network generated from the top-ranking 100 DM promoters MAPK1 FYN APPL1 LTC4S ADIPOR2 AURKB CHEK1 RPS6KA1 CHUK EP300 RPS6KA3 FXYD1 PMC6990892__F12 Pathway signaling network generated from the top-ranking 1000 DM promoters CAMK1 DDR1 APPL1 MYF5 GSK3B FHL2 MAPK9 RAB33B CXCL8 HDAC3 MAPK14 EZR CAMK2A CDK6 BCR SMO CDK3 NOTCH1 PIM2 ITGB7 CLTCL1 CTSK ZNF692 MIF AREG FURIN ANGPT2 YAP1 DAPP1 FES MAP3K5 ELF3 AVP CSF2RA AVPR2 TSHR ABL2 ARHGEF25 SPHK1 RPS6KA1 PRKCB NME2 NOD2 HDAC5 DLL3 MYOD1 GNAT1 MEOX1 PIM1 ATG16L1 ERBB4 KRT14 ARHA RAC1 PAX1 MDFI HDAC1 LYN BCL6 LCK PRKD1 SHC1 SKP2 MAP2K6 MBP SRC PAX3 CAST NOTCH2 MYOG CDK5 ATG12 LAMB3 CDK2 BCOR TRADD UHMK1 CSF3 CTNNB1 CSF3R EEF2K BTK PRC1 GPA2 RIPK1 ATM NOD1 CAMK4 CDC2 HRH1 CAV3 HMGB1 HOXC6 FGF2 GSK3A RELA CHEK1 SKP1 FGFR3 RPS6KA3 PMC8900870__F1 Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions PANX1 NOS1AP SRC PMC3724785__F7 Lysine-Specific Demethylase 1 (LSD1/KDM1A) Contributes to Colorectal Tumorigenesis via Activation of the Wnt/Β-Catenin Pathway by Down-Regulating Dickkopf-1 (DKK1) DKK1 APC GSK3B LRP5 KREMEN1 LRP6 CTNNB1 PMC11830738__F7 Interaction between malignant T cell and CAFs with SOX4-related mechanisms in the process STAT3 EZH2 TWIST1 SOX4 CTNNB1 PMC7875961__F3 Horizontal pleiotropy of common genetic factors TREM2 CSF1 CCR5 PTK2B PMC2819346__F1 Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance LPA HMFN0839 PC PMC6207163__F2 Modulators of Redox Metabolism in Head and Neck Cancer STAT3 EGF EGFR PTEN GRB2 MTOR SRC PMC6464042__F6 mTORC pathway regulation KEAP1 DDIT4 FLCN LCMT1 MTOR LAMTOR2 BDH2 MAPKAP1 SNAPIN PDPK1 VPS18 LAMTOR1 VPS16 VPS33A GNB2 LAMTOR3 ARL8B VPS29 MLST8 VPS35 TSC2 RICTOR TSC1 TIPRL VPS41 WDR59 VPS39 SEH1L AP3B1 MIOS WDR24 PMC2721397__F2 Key pathways in hepatocarcinogenesis and molecularly targeted agents currently under investigation in treatment of advanced HCC EGF HGF MTOR PMC8835994__F2 MAPK/ERK Pathway as a Central Regulator in Vertebrate Organ Regeneration STAT3 HEL-S-76p JUN RRN3 BCL2 ATF1 MYC RAC1 FOS PMC4622872__F1 Pathways that play important roles in melanocyte and melanoma development EGFR C1R BRAF KIT TYRP1 PTEN SOX10 MTOR CDK6 TRAF1 VCAM1 TRAF2 CDK4 PMC6320933__F3 Regulatory network of MBP-1 PIGF MEI1 ERBB2 PMC7423166__F9 Mechanism for hepatocyte PPARA activation on BA synthesis and transport regulation NR1C1 ABCG8 ABCG5 CYP8B1 BAAT CYP7A1 HSD3B7 CYP7B1 CYP27A1 PMC12190794__F1 NcRNAs involved in the regulation of DIC TINCR PMC8750350__F3 Cell Death in Hepatocellular Carcinoma: Pathogenesis and Therapeutic Opportunities HMGB1 GDF15 CXCL1 FBP1 CCL2 CD68 PMC4622872__F3 Epigenetic regulators as central components in melanoma signaling DNMT3B HDAC1 CDKN2A CDK6 PRC1 BRAF MTOR CDK4 PMC8750350__F1 Cell Death in Hepatocellular Carcinoma: Pathogenesis and Therapeutic Opportunities RIPK3 FAS CASP8 TRADD MLKL CASP3 BCL2 RIPK1 TNF TRAF2 FADD PMC8541492__F1 COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis CYP2R1 CYP27B1 PMC3504253__F1 Inactivated Wnt pathway APC LRP5 LRP6 PMC7179660__F8 Mechanism by which DDT inhibits oxidative stress and apoptosis in PC12 cells DDT BAX SIRT1 PMC8428888__F2 Preimmune Recognition and Response to Microbial Metabolites RBX1 KEAP1 MAF PMC3083967__F5 Key regulators of the mammalian target of rapamycin signaling pathway TSC2 RICTOR TSC1 SGK1 PTEN MTOR PMC8575759__F7 Microglia Activation in Retinal Ischemia Triggers Cytokine and Toll-Like Receptor Response TLR3 TLR4 MYD88 PMC8282711__F1 One Carbon Metabolism and Early Development: A Diet-Dependent Destiny MTHFD2 DHFR CTH MTRR TYMS MTHFD1 HEL-S-182mP PEMT SHMT1 PC CHDH ChAT HEL-S-61p MTR PMC8959714__F2 Understanding the Role of SARS-CoV-2 ORF3a in Viral Pathogenesis and COVID-19 TMPRSS2 FURIN ACE2 PMC118037__F6 Model depicting direct and indirect regulation of clock output genes involved in conidiation PMC3504253__F2 Activated Wnt pathway APC LRP5 LRP6 CTNNB1 PMC9348619__F6 Differentially Active and Conserved Neural Enhancers Define Two Forms of Adaptive Noncoding Evolution in Humans KLF4 JRK GSK3B STK4 NR1C2 PSEN1 MYC CTNNB1 UBR5 CTBP2 CSNK1E SOX7 SOX4 SIAH1 TLE3 GSKIP TBL1X APC TLE4 GPC3 TEM5 PYGO1 DRAXIN BCL9L RAPGEF1 FAM53B CER1 MAP3K7 SKP1 NLK DDX3X PMC8773419__F1 DNA Methylation: A Promising Approach in Management of Alzheimer’s Disease and Other Neurodegenerative Disorders DNMT3B TDG PMC4523609__F9 Upstream negative regulators of the Hippo pathway LATS1 LPA LATS2 EGFR SRC PMC7277648__F1 Anti-aging mechanisms of metformin: From metabolic controller of longevity to the sentinel of epigenetic information OGA OGT MTOR SIRT1 PMC7986977__F5 Metabolic pathway associations of significantly different metabolites in COVID-19 TPH1 IDO1 KYNU KMO TPH2 DDC MAOA IDO2 PMC11998454__F4 Exosomes secreted by BMSCs, modified with HO-1, deliver miR-124-3p STEAP3 GPX4 PTEN PMC7705115__F4 Crosstalk between JAK2-STAT5 and hormone receptors, growth factors, inflammatory cytokines, and integrins ERBB4 SMAD2 PMC1774725__F1 Tumour necrosis factor related apoptosis inducing ligand (TRAIL) receptor signalling TRADD TRAF2 FADD PMC8197327__F1 Emerging Roles for Browning of White Adipose Tissue in Prostate Cancer Malignant Behaviour BAX CXCL12 BCL2 TRAF6 CXCR4 PMC7705115__F1 Novel components of the JAK2-STAT5 signaling pathway SOCS2 CUZD1 PMC3356660__F1 A model summarizing the results of the study in which the miR-301a molecule inhibits the PIAS3 enzyme, resulting in the promotion of the IL-6/23 receptor–STAT3 pathway and stimulation of Th17 differentiation STAT3 IL23R PMC7705115__F3 Crosstalk between the PI3K/Akt and JAK2-STAT5 signaling pathways PIR IGF1R PMC8832510__F2 Forkhead Box Family in Bone Metabolism and Diseases SMAD1 ANXA2 RUNX2 TRAF6 CTNNB1 FOXD3 FOXF1 FOXC2 FOXO1 FOXQ1 BMP4 FOXC1 BMP2 MSC FOXA2 ATF4 SRC MSX2 PMC7912673__F1 Panel (A): Mechanisms of drug inhibition on cellular pathways RHEB TSC2 TSC1 PTEN PMC5766647__F3 Regulatory T cells are controlled by epigenetic mechanisms and T cell receptor (TCR) and interleukin-2 (IL-2) pathway ICOS FOXP3 MTOR PMC5626664__F4 Tobacco-specific carcinogens induce hypermethylation, DNA adducts and DNA damage in Bladder Cancer CTRL CDH2 CR1 PMC4446786__F1 Intracellular mechanisms activated by leucine RHEB MLST8 IGF1 SLC7A5 DEPTOR IRS1 PMC2943488__F1 Schematic of the drug- and cytokine-induced hepatocellular death signaling network, curated from literature references-, - STAT3 BAX CASP9 BAD TRADD IRAK1 MTOR TNF INS TRAF6 IRS1 MYD88 CASP6 CASP3 GRB2 TRAF2 TYK2 UNK FADD PMC5253631__F8 Exome and genome sequencing of nasopharynx cancer identifies NFKB pathway activating mutations MSH6 PIK3CA IKBKE PTEN MTOR TRAF3 TRAF6 KRAS CDKN2A FBXW7 NF1 NFKBIA NRAS EP300 HLA-B HLA-A CYLD CCND1 PMC3025434__F1 Simplified overview of the pathways involved in miRNA regulation of gene expression in addiction SEMA4C AGO2 PER2 RGS4 NRP2 STAT4 ATF2 MTOR BDNF DROSHA PMC3762715__F5 Transcriptome Profiling Reveals Th17-Like Immune Responses Induced in Zebrafish Bath-Vaccinated with a Live Attenuated Vibrio anguillarum JUN APC GSK3B ARHA CTNNB1 PMC6781988__F8 Proposed mechanism of miR-125a-5p function in HCC BAX PTPN1 MAP3K11 PMC9581121__F1 Amino acid metabolism in primary bone sarcomas ASS1 HEL-S-133P PHGDH DHFR SHMT1 PSAT1 ASNS GLS2 PSPH PMC3027158__F7 Biological network of genes linked to the canonical pathway "molecular mechanisms of cancer" that were hypomethylated (fold change >1.5) in zebrafish hepatocellular carcinoma compared to healthy liver MAX BAX JUN BAD APC RBL1 MME C2 NF1 SUFU ATM HEL-S-11 MDM2 CP PMC8833225__F4 Cathepsin family target genes in phagosomes HEL-S-62p CD36 VAMP3 CD14 TUBB MPO HEL-S-99n RILP TLR4 STX18 STX7 MARCO M6PR PIKFYVE PMC2610122__F1 Classical view of three independent Wnt signalling pathways APC ROR2 ARHA NLK PMC3027158__F8 Ingenuity network predicted for genes that were both hypomethylated and increased in expression in zebrafish HCC (shaded red) NPM1 CP PMC7716795__F1 Host genetics and infectious disease: new tools, insights and translational opportunities SPPL2A TBK1 TIRAP MAVS RFX5 RFXANK IRAK1 RFXAP IRAK2 TAP1 TRAF6 MYD88 STAT1 MHC2TA TAP2 IFNGR1 STAT2 IRF9 IRF3 IRF7 RIPK3 TLR1 MAP3K7IP1 TRIM25 IFNAR2 IFNAR1 JAK1 TYK2 PMC9019694__F2 Apoptosis, autophagy and ferroptosis by non-coding RNAs in metastatic non-small cell lung cancer (Review) CDH2 STAT3 KLF2 KLF7 HMGA2 PXN EGFR SMAD2 EZH2 PTEN CCNA2 RAP2B LATS2 SOX9 CCND2 LDLR HDAC9 ERBB2 CDK14 CDK4 PMC9019694__F5 Apoptosis, autophagy and ferroptosis by non-coding RNAs in metastatic non-small cell lung cancer (Review) DRAM2 TNNC1 MAP4K3 ATG3 UBE2C H2AX TIPRL FOXO3A DVL2 MTOR NIPBL PMC12018836__F4 Illustration of eATP signal transduction TH ECD MYC MVK PMC6137108__F3 Enriched KEGG dopaminergic synapse pathway following perinatal nicotine exposure in DA neurons GNG2 CALML3 DRD2 GNG13 PRKCA GNG12 EN1 PPP3CA CALML4 GNG7 GAB4 PRKCH PMC3641182__F2 Humanin: a harbinger of mitochondrial-derived peptides? STAT3 BAX CNTFR PMC11278003__F5 KEGGs pathway and GO molecular function (MF) analysis based on AD correlated interactors of Apaf-1 and TNFA CRP IL10 TLR4 HEL-S-162eP IL6 TNF INS IL1B PMC6137108__F4 Enriched KEGG neurotrophin signaling network following perinatal nicotine exposure in DA neurons TP73 BAX MATK JUN BAD RAF1 SOS1 CRKL KRAS IRAK4 HRAS MAPK4 CRK HEL-S-47e SOST SORT1 CAMK2D IRAK3 RELA SART1 RAP1A SHC3 ARHGDIG HEL2 PMC5297631__F1 Inflammatory role of phagocyte apoptotic pathways in rheumatic diseases APAF1 FADD PMC6667250__F3 Feed efficiency and the autophagy pathway NBR1 ATG16L1 KIAA0226 ULK1 UVRAG ATG14 MTOR ATG10 MAP1LC3C ATG3 ATG12 PEMT BCL2 ATG5 PMC6548002__F5 Signaling pathway based on the literatures we reviewed NRCAM PTN ERBB4 IL34 PTEN SRC MYC CCND1 DNER CTNNB1 PMC1682017__F5 Effect of HRG stimulation versus EGF stimulation in high HER2-expressing cells EGF HRG SRC PMC8469440__F3 Kynurenine Pathway—New Linkage between Innate and Adaptive Immunity in Autoimmune Endocrinopathies TH APC AHR MTOR PMC7564545__F2 Interplay between innate immunity and hepatitis E virus (HEV) TBK1 STAT1 MAVS TLR3 STAT2 IRF9 IFIT1 IRF3 IRF7 ISG15 TYK2 PMC9056228__F2 Research Progress of Ferroptosis in Adiposity-Based Chronic Disease (ABCD) IPP GPX4 DHFR DHODH PMC5609334__F1 NF-kB pathway FAS BCR EDAR PMC8469440__F1 Kynurenine Pathway—New Linkage between Innate and Adaptive Immunity in Autoimmune Endocrinopathies HEL-S-90n IDO1 KMO IDO2 PMC2203613__F10 Functional interacteome of all parietal cortex proteins EGF GSTM2 JUN PTGER3 TGFB1 PKN2 PTGS2 MAP2 NEFL MAPK8 FGF2 GCG GLUD1 HEL-S-29 FBP1 APP HEL-S-87p PMC11281655__F2 RIG-I-like receptor signaling pathway in antiviral immunity BRD4 TBK1 MAVS IRF3 IRF7 PMC9653755__F2 Current Status and Prospects of Targeted Therapy for Osteosarcoma AURKA AURKB WEE1 MTOR PMC6026538__F2 Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense ABCG1 NLRP3 CD36 TLR4 APOE IL18 IRF3 IL6 ABCA1 PMC8588809__F2 Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome RHEB RPS6 TSC2 EIF4B TSC1 INSR ULK1 PC HIF1A RHO ELF3 EIF4E PMC8777795__F3 Novel Pathway of Flavonoids Protecting against Inflammatory Bowel Disease: Modulating Enteroendocrine System CCK IGF1 DPP4 PMC4543455__F5 Canonical Wnt pathway TUB APC NR1C2 PCK1 CCND1 PMC6305104__F3 MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer POR THPO PMC6305104__F2 MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer RAF1 SOS1 PIK3R3 MCL1 PIK3R2 AKT3 PIK3R1 SOCS2 MTOR MYC STAT1 BCL2L1 FHL1 CCND1 AOX1 PIM1 IRF9 PTPN6 HRAS GFAP CREBBP BCL2 STAT4 JAK1 GRB2 CISH STAM2 PMC7903498__F1 Effect of Melatonin Modulation of Non-coding RNAs on Central Nervous System Disorders: An Updated Review PTEN SIRT1 PMC4105970__F5 Schematic model of specific KDAC targeting through pharmaco-logic modulation of its regulatory pathway HDAC1 CUEDC2 SP1 HDAC2 PMC8192756__F10 Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway CD14 TRAF6 MYD88 PMC9570387__F3 Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance MAPK1 KCNQ2 MAPK3 PMC9691176__F1 Vascular Endothelial Growth Factor Receptor 2: Molecular Mechanism and Therapeutic Potential in Preeclampsia Comorbidity with Human Immunodeficiency Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections CDC42 VEGFB VEGFC PIGF VEGFA PMC6905088__F8 Relative P450 involvement in N-dealkylation pathways of terbinafine CYP1A2 CYP2B6 CYP2C19 CYP2C9 CYP2C8 PMC2224586__F3 HCMV regulates the expression of multiple components of the NFKB signaling pathway (see Table and Table S1 in the supplemental material for abbreviations) CD40 EGF NGF LTA TIRAP BMP4 RELA RELB BMP2 TNF LCK PMC7297305__F4 LncRNA-miRNA-mRNA network for human primed, naive and extended pluripotent stem cells WNT5B TGFA PMC6982094__F3 Exogenous GM3 and the EGFR-mediated PI3K/AKT signal pathway BAX EGF GAL PARP11 MTOR PMC6905088__F4 Metabolic model predictions for P450 catalyzed N-dealkylations CYP1A2 CYP2A6 CYP2B6 CYP2E1 CYP2C19 CYP2C9 CYP2C8 CYP3A4 PMC3064843__F5 DNA Repair Deficiency and Neurological Disease XPA LIG1 XPC PMC8195768__F2 Manifold role of ubiquitin in Helicobacter pylori infection and gastric cancer CDC42 TIFA CTNNB1 PMC3227781__F2 Genomic and nongenomic vascular effects of estrogen COX1 GC ARHA SRC PMC4936004__F4 LumA-R2 samples overexpress genes in the T cell receptor signaling pathway CD48 ICOS CBL FYN BCL10 LAT ITK CTLA4 GRB2 LCK PMC3068924__F4 CAERUS: Predicting CAncER oUtcomeS Using Relationship between Protein Structural Information, Protein Networks, Gene Expression Data, and Mutation Data IDE JUN SLA APC BRAF RHO CCNC TFRC SOST RALA NRAS PC CDK2 PS1TP5BP1 PMC5181566__F3 Two sets of peripheral proteins (blue and red) with the same core proteins (green) are shown RB1 STAT3 SMAD9 JUN SP1 BRCA1 SMAD2 RELA CREBBP EP300 PMC8564637__F7 MeCP2 drives hepatocellular carcinoma progression via enforcing HOXD3 promoter methylation and expression through the HB‐EGF/EGFR pathway HBEGF HOXD3 EGFR CREB1 PMC7783757__F7 Interrelation between 4 target metabolites and 4 concurrently mutated genes GATA2 RCC1 SMAD9 DGKB MGLL PLA2G2F RB1 HAX1 PLA2G10 SPTLC2 BCR PLCG2 ARID1B RBM7 PLA2G15 ARHGAP18 A2M NRF1 DCN CEBPE MAPK1 UBE2E2 BCLAF1 C3orf57 TCF7L2 GPAM GPD2 CHGB DGKD CHERP RXRA DGKE MCM6 ChAT NFYC PRCC CHKA CDK9 GNA13 IL12RB1 CDC42 ARID1A IMMT SPTLC3 EGFR ABCA1 CTCF PLCG1 DGKA SHBG RBM10 MLX CSTF2 DGKZ ACHE JUN PTN PLD2 ARIH2 FLJ10842 ARHA RERE NCOR2 SF1 MAD2L2 PEMT NFYA SMARCD3 CREBBP EP300 RAB35 ZNF263 HEL-S-87p GAB2 PS1TP5BP1 PMC8996108__F7 Blueberry Juice Attenuates Pulmonary Fibrosis via Blocking the TGFB1/Smad Signaling Pathway STAT3 SMAD2 BLM PMC8100510__F1 Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies SUFU APC SMO CTNNB1 GLI3 PMC3099707__F10 Dual MC4R signaling model to account for “rescue” of Ay phenotype by alterations in MC4R trafficking MGRN1 MC4R TSG101 PMC4333206__F1 Notch receptors (Notch1-4) and ligands (DLL1, 3 and 4, Jagged 1-2) are expressed in tumor, normal, and endothelial cells DLL4 CDK2 CTNNB1 PMC2715810__F7 Model of PERK pathway controlling rRNA transcription and translation in comparison to mTOR RRN3 POLI MTOR EIF2A PMC2854204__F1 TOR-dependent control of autophagy: biting the hand that feeds RHEB TSC2 TSC1 BNIP3 PMC4042557__F4 Graphical overview of the Canonical Pathway analysis SRC BDNF PMC5727168__F7 Hypoxia/IL-6/lncTCF7/TCF7/Wnt signalling axis in glioma STAT3 SOX2 MIF CCND1 IL6R PMC6019481__F9 Regulation of the synaptic vesicle cycle pathway by SE in OVX with (CES)/without (COS) E2-replacement with respect to their non-SE counterparts (CEN and CON) NAPA STXBP1 AP2S1 CACNA1A SLC17A6 RIMS1 VAMP2 SLC17A7 CACNA1B UNC13A CPLX1 AP2M1 AP2A2 SNAP25 STX1A SYT1 PMC4259419__F2 AXL kinase as a novel target for cancer therapy AXL GAS EGFR GRB2 PMC9668530__F2 Recent advances in understanding the metabolic plasticity of ovarian cancer: A systematic review UCP2 HEL-S-133P PMC9902738__F2 Potential benefits of cinnamon to patients with diabetes, obesity, or CVDs NR1C1 TRPA1 CD36 UCP1 PMC5570638__F1 Mammalian target of rapamycin pathway TSC2 TSC1 IGF1 HIF1A PMC4148087__F7 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention BRCA1 BRCA2 ATM MDM2 CCND1 PMC4148087__F6 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention RHEB PIK3CA TSC2 INHA ULK1 EGFR PTEN SRC PMC4148087__F5 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention PTEN MTOR CTNNB1 PMC5821844__F7 Differentially expressed artemisinin and other terpenoid biosynthetic pathway genes of A IPP MVP IL1A MVK PMC4148087__F4 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention IGF1 PTEN IGF1R PMC10131518__F2 Primary and Secondary micro-RNA Modulation the Extrinsic Pathway of Apoptosis in Hepatocellular Carcinoma CD44 STAT3 JUN TGFB1 ITCH TNFSF6 DDIT3 BCL2 VEGFA CCL2 PTPN13 TNFRSF10A PMC4148087__F3 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention CD44 CD24 CIC PTEN IGF1R PMC2759177__F3 Survival signals generated by PI3K and PLD that target mTOR RHEB TSC2 BAD TSC1 GSK3B PTEN MDM2 PMC4148087__F2 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention RHEB EIF4B TSC1 RAF1 NF1 PHLPP2 PDGFRA KIT CDK2 DUSP4 PTEN CTNNB1 PMC7210543__F3 Scribble complex in immune cells CDC42 ZAP70 IFNG CRTAM PMC9321239__F7 Altered RNome expression in Murine Gastrocnemius Muscle following Exposure to Jararhagin, a Metalloproteinase from Bothrops jararaca Venom MAX ECSIT EGF FAS TRADD APMAP CD14 TNF DAO FLNA FER APP HP NLK TRAF2 PMC7215568__F2 Action of MNKs SPRY2 ANGPTL4 SMAD2 CDK2 NODAL GRB2 MTOR DEPTOR CCND1 CTNNB1 EIF4E PMC7982081__F5 Angiocrine factors control liver function CXCL9 BMP6 BMP2 ARG1 WNT9B RSPO3 GPR49 AXIN2 PMC5548098__F1 The major pathways of Cu distribution in human cells ATOX1 CCS ATP7B COX17 HEL-S-44 PMC5964132__F4 Multiple signaling pathways are upregulated in MCF7 parathyroid hormone-related protein-overexpressing cells EREG AFF2 PELO FUOM BMPER AREG PMC5332279__F5 Schematic model of the TRIM8‐PIAS3‐STAT3 pathway that regulates glioblastoma stemness STAT3 SOX2 TRIM8 PMC11673418__F1 Simplified schematic representation of the PI3K/AKT/mTOR, RAS/RAF/MAPK, RB, and p53 pathways RB1 MDM4 CDKN2A CDK6 PTEN MDM2 MTOR CDK4 PMC9250260__F3 p63 regulated pathway in cancer BAX APC SOX2 PML PMC8625071__F1 Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery STAT3 BAX WAS EZH2 PTEN MTOR PMC5449640__F5 Hypothetical driver pathways for BRCA carcinogenesis and progression ARID1A IFNA6 PIK3CA FAS CASP8 RAD51 BRCA2 PIK3R1 KRAS GATA3 CTNNB1 FGFR2 MAPK14 LPA XB MAP2K4 MAP3K1 NF1 CDKN1B ERBB2 ATM FGFR3 PMC5449640__F4 Known KEGG pathway knowledge in cancer LPA PIK3CA XB MAP2K4 MAP3K1 PIK3R1 ERBB2 KRAS FGFR2 PMC7532371__F5 Red nodes are genes of CMTgset, and the green nodes are nonoriginal/extended genes HSP90AB1 HEL-S-101 SFRS18 DCTN4 EGFR MAPRE1 SCLT1 ATP1A1 MTMR1 DCTN5 STUB1 NEFH TMEM17 SBF2 MAGED1 MLF2 MTMR2 BICD2 HSPA4 AATK HEL55 SNW1 HSPB8 GRB2 PMC7532371__F4 Biological process crosstalk among CMTgset-enriched biological processes tmp_locus_29 PROC PMC5902451__F3 Downstream interactors affected by deleterious SAPs in CTNNB1 and KRAS PTPRM CDC42 CDH2 RAF1 APC TCF7L1 APC2 KRAS AXIN2 RAC1 CTNNB1 TCF7L2 CTNNBIP1 SHOC2 AXIN1 LEF1 RALBP1 PMC6435474__F4 Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of ClockΔ19 mutant mice TGFB1 NR1D1 PPP2CA MYC APC2 TGFBR1 LATS1 PER3 BIRC5 CSNK1E PPP2R2B CCND2 HEL-S-80p NR1D2 CRY2 CCND1 YWHAG BMPR2 PER2 PER1 APC CRY1 BMP7 PPP2R1A AXIN1 SCRIB PMC9461657__F4 Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions CDC2 TBK1 PINK1 CDK6 CCNE1 ULK1 GSK3B ATM MYT1 MTOR PLK1 CCND1 PMC9367281__F4 PTEN in Epithelial–Mesenchymal Transition SMAD2 SMAD4 PTEN SRC PMC6232459__F7 HBSP regulation on PI3K/Akt signaling to affect Fas-apoptotic pathway FAS PDPK1 FADD PMC7551260__F2 Antiviral immune response and evasion mechanism of coronaviruses TMPRSS2 TBK1 IFNLR1 MAVS IRF1 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR3 DPP4 TLR8 TLR7 PLP2 TYK2 ACE2 IL10RB PMC2652310__F1 Anaerobic metabolic pathways in C PDC HEL-S-32 MDH2 PMC11673418__F7 Wnt/Beta-Catenin Pathway APC LRP5 LRP6 CTNNB1 PMC11673418__F9 TGFB signaling pathway in gene expression regulation SMAD2 SMAD4 PMC9367281__F1 PTEN in Epithelial–Mesenchymal Transition RHEB TSC2 TSC1 PTEN PMC5777710__F13 CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NFKB/ iNOS pathway in STZ-induced diabetic mice SMAD2 CDK2 NOX4 PMC6121636__F1 HO-1 dependent pathway activated in neurons and in the different glial cells BACH1 GDNF BDNF PMC10926848__F4 BCR signaling pathway and BCR-associated CXCR4 signaling in CLL RHEB CXCL12 SYK TSC2 TSC1 BCR PLCG2 CD19 PTEN LYN CXCR4 PMC4187706__F9 Schematic model showing AngII regulation of HSD3B1 in H295R cells HSD3B2 CYP11B2 HSD3B1 PMC8855721__F7 Potential mechanism of the effects of HF-MSCs in the treatment of LC ACTA2 SMAD2 SMAD4 PMC11074996__F1 The multi-modular engineering and efflux strategies for lycopene synthesis in Saccharomyces cerevisiae IPP IDI1 ERG PMC5146274__F8 Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis POSTN ITGB3 ITGAV PMC12145652__F7 GETV Nsp2 inhibiting the RLR signalling pathway by regulating IRF3 activation TBK1 RIGI MAVS KPNA3 KPNA4 IRF3 PMC6127653__F2 Role of p21-activated kinases in Kras-driven oncogenic signalling pathways CDC42 CRK ADM KRAS RAC1 PMC3903702__F1 EZH2 takes the stage when BRCA1 loses ME3 SUZ12 EED BRCA1 EZH2 PMC140507__F1 The PI 3-kinase pathway by RNAi PTEN PMC6399846__F2 KIT mutant GISTs have enrichment for KEGG cell cycle pathway (p = 0.0007) and spliceosome pathway (p = 0.0008) using STRING v10 clustering of significantly somatic mutated genes (p < 0.003) RBMX HECW1 JUN TCOF1 MSH3 USF1 KIT AAAS CLK1 FBXO2 CLINT1 RB1 SF3A2 NRG1 RBMXL3 SPDYE1 FRG1 U2AF2 QRICH2 CDC27 EDAR PMC8019700__F2 Human rhinoviruse (HRV) replication and inflammatory response CDHR3 IL16 LDLR IL6 PMC4747800__F1 PI3K/AKT/mTOR pathway and cellular processes controlled by downstream signaling TSC2 BAD RICTOR PHLPP1 FOXO1 PHLPP2 EBP GSK3B PTEN MTOR CCND1 PMC7077606__F1 SFRP5 at the crossroad between obesity, T2DM and CHD SFRP5 ROR2 RHO PMC8158769__F1 Targeting the Complement Cascade in the Pathophysiology of COVID-19 Disease HEL-S-62p C2 C4A PMC9898571__F7 Osteoarthritis: pathogenic signaling pathways and therapeutic targets TGFBR2 SMAD1 DKFZp781O1323 SMAD2 SMAD4 RUNX2 TGFBR1 PMC12058719__F2 Osteoporosis (OP) regulation by protein arginine methyltransferases (PRMTs) (A)PRMT1 influences bone formation and resorption through the BMP2/Smad and other pathways, thereby mitigating OP PRMT1 SMAD9 SMAD1 PRMT7 DKFZp781O1323 PRMT3 PRMT6 DDR2 RSAD2 CXCL10 TRAF6 ME2 MSX1 MSC PMC9898571__F3 Osteoarthritis: pathogenic signaling pathways and therapeutic targets FRZB LRP5 LRP6 RUNX2 CTNNB1 PMC9898571__F6 Osteoarthritis: pathogenic signaling pathways and therapeutic targets STAT3 ADAMTS4 ADAMTS5 VEGFA RUNX2 CTNNB1 PMC9327256__F7 Pretreatment of nucleus pulposus mesenchymal stem cells with appropriate concentration of H2O2 enhances their ability to treat intervertebral disc degeneration LATS1 BAX HEL-S-8a LATS2 CCND1 PMC6186824__F2 BAFFR-induced intracellular signaling SYK BTK BCR PLCG2 RELB BLNK CD19 TRAF3 MTOR SKP2 TRAF2 EIF4E PMC8535999__F1 Receptor-Loaded Virion Endangers GPCR Signaling: Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications NRP1 PALS1 ACE2 PMC5094909__F1 Energy Metabolism and Inflammation in Brain Aging and Alzheimer’s Disease IGF1 GRB2 INS PMC5964014__F7 Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury BAX JUN SARM1 PMC7971856__F7 Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol SHARPIN CGAS MAVS TLR4 PMC8387591__F1 Mouse Models of Germinal Center Derived B-Cell Lymphomas TET2 CCND3 TH CD79B FAS TNFRSF14 MEF2B HEL-S-62p PRDM1 EZH2 MYC MYD88 FOXO1 MLL2 CREBBP BCL2 BCL6 GNA13 PMC8834116__F7 Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway ACTA2 HEL113 COL1A1 PMC7485387__F3 FGF23 signaling in the kidney CYP27B1 CYP24A1 TRPV5 EGR1 FGFR1 FGF23 PMC6705128__F2 DUBs regulating TCR signaling ZAP70 USP15 LAT OTUD7B USP18 MDM2 USP9X CYLD PMC5449757__F1 Schematic depiction of uPAR/suPARAvB3 integrin signaling at the glomerular filtration level in health and diabetic disease IGF1 VTN PMC7485387__F1 FGF23 regulation in osteocytes NR1i1 STAT3 EGR1 ORAI1 DMP1 IGF1R TRAF6 FGF2 MYD88 ALK FOXO1 TLR4 FGFR1 HEL-S-11 PTH PTH1R IL1B FGF23 PMC5725996__F1 Summary diagram of energy metabolism pathway ENO2 NDUFA9 HEL-S-133P NDUFV3 CS PCK1 NDUFA10 ATP8 OGDH ATP6V0A4 ND5 PFKP FBP1 PC LDHD HEL-S-87p PKLR LHPP PMC2997002__F2 Gene list involved in TLR pathway generated by KEGG MYC PMC2997002__F3 MAPK signaling pathways generated by GenMAPP TES RAN JUND CASP2 GNAT2 BRAF CD14 KRAS PRKCH SET IKBKG PRKCE SOS2 GCK BDNF PMC5858821__F1 Illustration of self-assembly and accumulation of redox-sensitive PTX-HSV nanoparticles in tumor tissues and their intracellular trafficking pathway CD44 NHS PMC3792586__F1 TNF signalling pathway MADD TRADD TNF TRAF2 FADD PMC7881277__F1 Deregulated MicroRNAs in Age-Related Macular Degeneration Pathology CASP9 BAD SPHK2 COX2 KRAS PMC8446557__F3 EGFR‐mutated stage IV non‐small cell lung cancer: What is the role of radiotherapy combined with TKI? ERBB3 RAD50 RAD51 MRE11A PCNA BRCA1 GSK3B ERBB2 ATM CTNNB1 PMC7710791__F2 Pathway 1—management of a previously healthy child/adolescent, suspected, or probable case of COVID-19 ACAN POR HEL113 FER SI PMC7881277__F3 Apoptosis signaling pathway and the predicted gene targets of miR-410 (IL1R, XIAP, NTRK1, PPP3CA, PRKACB3) and miR-19a (IL1R1, PIK3R3, MAP3K14, PRKACB3), which are involved in cytokine–cytokine receptor interaction BAX BAD FAS TRADD ATM FADD MYD88 PMC7530066__F9 Insulin-like growth factor 1-Receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axis IGF1 ATF4 IGF1R MTOR PMC7881277__F2 Deregulated MicroRNAs in Age-Related Macular Degeneration Pathology C6 CD59 CPB2 KLKB1 HEL-S-62p F5 F7 CR2 C4A PLAT F2R F2 F10 F3 C9 THBD A2M F8 F9 PROC VWF C7 PLAUR PLG F11 TFPI C2 PMC5979464__F3 Beta2-adrenergic receptor signal transduction ADRBK1 TH GRK1 PMC7881277__F4 Neurodegenerative disorders signaling pathway and the predicted gene targets of miR-19a (SOD1) and miR-126, which are involved in the insulin signaling pathway BAX BAD PINK1 CASP8 LRRK2 HEL-S-67p NGFR APOE HEL-S-89n SNCA HEL-117 NEFH APBA1 BCL2L1 GFAP CASP6 CASP3 CREBBP BCL2 APP APLP1 GRB2 HEL-S-44 PMC7816079__F5 Saponin biosynthetic pathway in P. notoginseng and expression profiles of key enzyme genes.The genes in the green box are the UGT genes identified in this study GGPS1 IPP MVD DST MVK SST PMC5979464__F1 The major neuroendocrine and autonomic pathways that regulate secondary immune organs are illustrated CORT CRH PMC6817488__F5 AA-induced vasorelaxation and relationship to aldehyde metabolism ALDH2 GC PMC5979464__F4 Canonical B2-adrenergic receptor (B2-AR) signaling response, the anti-inflammatory cytokine profile mediated by protein kinase A (PKA), and the major anti-inflammatory cellular mediators of the resulting anti-inflammatory immune response ADRBK1 GRK1 PMC10941343__F12 Elucidating the anti-hypertensive mechanisms of Uncaria rhynchophylla-Alisma plantago-aquatica L: an integrated network pharmacology, cluster analysis, and molecular docking approach MAPK1 EGF ROCK2 EGFR VCAM1 MDM2 SRC CTNNB1 PMC2674225__F2 Repression of TGFB-RII and abrogated signaling through the Smad pathway IFNG STAT1 EGF SMAD2 SMAD4 ARHA JAK1 TGFBR1 PMC7479443__F1 De novo purine synthesis pathway APRT PAICS ADSL PMC8283767__F2 Non-coding RNAs in Alzheimer’s Disease: From Regulated Mechanism to Therapeutic Targets and Diagnostic Biomarkers RAD18 IGF1 EGFR MCL1 SPHK1 APP BDNF PMC8584118__F3 Nod-like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections IRF3 NLRC4 NLRP1 NLRP12 NLRX1 GSDMD NLRP6 NLRP3 TLR3 DHX15 IL18 NOD2 NOD1 TLR7 IL1B PMC3254618__F3 Identification of Gene Networks and Pathways Associated with Guillain-Barré Syndrome CORT BAD HEL-S-11 PMC6884345__F3 TGFB signaling in the colonic mucosa SMAD2 SMAD4 PMC4411486__F3 Predicted co-regulation of genes in the MAPK signaling pathway targeted by downregulated miRNAs in BAT during torpor MAX CD14 GRB2 DAO FOS PMC6122627__F5 The pathways being affected by MDD and by treatments KEAP1 DUSP2 MYD88 PMC4411486__F2 Predicted co-regulation of genes in the MAPK signaling pathway targeted by the downregulated miRNAs in WAT during torpor MAX JUN FAS MOS CD14 GCK KIN DAO PMC4411486__F4 Predicted co-regulation of genes in the TGFB signaling pathway targeted by upregulated miRNAs in WAT during torpor IFNG INHBA SMAD4 SKP1 NODAL ARHA PMC6071023__F2 Resistance to EGFR tyrosine kinase inhibitors RHEB EGF TSC2 TSC1 EGFR SMO GATA6 MTOR WNT7B KRAS PMC7105297__F1 Genome-wide CRISPR/Cas9 screen for positive regulators of SL biosynthesis ARPC4 GOLPH3 UGCG SPTSSA ARPC3 CERS2 KDSR NCKAP1 ACTR2 ACTR3 SPTLC2 TM9SF2 AHR TMEM165 SPTLC1 A4GALT PMC5867104__F2 Wnt/beta‐catenin pathway‐related lncRNAs and their interactions in cancers FZD8 HNRNPK CTNNB1 PMC5867104__F1 Wnt/B‐catenin signalling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC8946235__F1 Targeting the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Colorectal Cancer MAX ERCC1 MSH6 RAD51 MSH2 PMS2 PCNA BRCA1 BRCA2 PALB2 SSB PARP1 PMC12111560__F5 Expression profile of candidate genes involved in the organic acid metabolic pathway in pomegranate CS ME1 PMC8048608__F3 UPR pathway highlighting gene‐expression differences between the low‐risk and high‐risk PSC clusters HEL-S-99n OS9 CANX SEL1L BCL2 AMFR ATF4 TRAF3 EIF2A XBP1 VCP TRAF2 PMC9393521__F1 Current therapeutic strategies and perspectives in refractory ITP: What have we learned recently? SYK BTK BCR MTOR PMC2945029__F6 Pathways and networks related to chondrocyte proteins identified by proteomics as altered by GS and/or CS HEL-S-22 PGAM1 HEL-S-68p ANXA2 HEL-S-269 HEL-S-7 HEL-S-102 ANXA1 HEL-S-87p PS1TP5BP1 PMC9699619__F2 Renin–Angiotensin-Aldosterone System, Nitric Oxide, and Hydrogen Sulfide at the Crossroads of Hypertension and COVID-19: Racial Disparities and Outcomes ACE2 PMC5877752__F1 Homocysteine (Hcy) metabolic pathway VIT PMC2730119__F3 Scheme showing the role of different signaling pathways in mediating the effect of high K intake on ROMK and BK channels in the CCD WNK1 WNK4 SGK1 PMC4167409__F1 Androgen biosynthesis in prostate cancer cells HSD17B6 CYP17A1 HSD3B1 AKR1C2 AKR1C1 PMC6298973__F8 Proposed TLR 2, 5, 8 signaling pathway MAP3K7IP1 TIRAP IRAK1 IRF7 TRAF6 IRAK4 MYD88 PMC7064973__F2 Theorised DIS3L2 and let‐7 pathway mediating gastrointestinal nematode (GIN) resistance DIS3L2 IL10 LIN28A TUT7 TUT4 PMC2932783__F1 Targeting of signaling pathways by arsenic trioxide in chronic lymphocytic leukemia cells PTEN MTOR PMC4028840__F1 PI3K/Akt/mTOR signaling pathway ] RHEB TSC2 TSC1 PTEN IRS1 PMC7203449__F4 Visualization of Gene Ontology (GO) enrichment profiles from DEGs using Cytoscape software based on network analysis of ClueGO/CluePedia inferred from MCODE cluster 1 (A) and cluster 2 (B) RRM2 APC MPEG1 MARCKS E2F7 NCF4 MAPK9 TYMS VEGFA CDK6 FYN E2F6 CHEK1 CP PMC5141617__F4 Conflict resolution in the genome: how transcription and replication make it work MAF1 ATR SETX MRC1 BRCA1 INO80 PMC4085491__F1 ELF4 in type I IFN signaling ELF4 TBK1 MAVS IRF3 IRF7 PMC10121353__F8 Main nodes of AGE-RAGE signaling pathway BAGE MCAM PC APP PMC8198876__F1 Targeted Therapeutic Approach Based on Understanding of Aberrant Molecular Pathways Leading to Leukemic Proliferation in Patients with Acute Myeloid Leukemia TET2 BAX SUFU CD33 SMO MTOR PMC8758495__F3 Amyloidogenic vs non-amyloidogenic pathway ADAM9 BACE1 APP PMC5727901__F1 Cyclin–CDK complexes and the cyclin D–CDK4/6–p16–Rb pathway in the cell cycleThe cell cycle is regulated by cyclins and checkpoints, with different cyclins (and cyclin–CDK combinations) and checkpoints acting at phase transition of the cell cycle CDC2 CDK6 CDK2 MTOR CDK4 PMC7046305__F7 Anti‐tumour mechanism of Tan‐Ⅰ BAX MTOR PMC4898689__F8 Integrated Analysis of the Roles of Long Noncoding RNA and Coding RNA Expression in Sheep (Ovis aries) Skin during Initiation of Secondary Hair Follicle LPL UBC UCP1 HEL-S-28 PMC8284746__F2 Metabolic Control of Mouse and Human Astrocytes MAVS CCL2 TNF PMC4436984__F2 Key signaling regulation of autophagy in the heart ULK1 IRS1 PMC8814460__F2 Inflammation and Myeloid Cells in Cancer Progression and Metastasis STAT3 CXCL12 CXCL5 CXCL1 CCL26 ARG1 CXCL2 SOCS3 CCL5 CCL2 CXCL8 CD47 CXCL17 CCL7 IL8RB CXCR4 CCL8 PMC8814460__F1 Inflammation and Myeloid Cells in Cancer Progression and Metastasis CD80 CXCL12 CCL18 CCL3 CXCL1 IL33 CXCL2 TNF MDC1 CCL24 CD33 PDC CD1C IL8RB CD163 CCL17 PMC8919643__F4 Untargeted metabolomics analysis of esophageal squamous cell cancer progression PTDSS1 PC LPCAT1 PMC3321553__F2 Coregulation of gene transcription by p53 and Smad complexes SMAD2 SMAD4 MDM2 PMC7290932__F5 Models for release of the Xenopus oocyte prophase block: probable cooperation between several receptors and downstream pathways IGF1 MOS IGF1R PMC9661388__F6 Basal diet composition contributes to differential performance, intestinal health, and immunological responses to a microalgae-based feed ingredient in broiler chickens GAL ACSL5 IDH3B MAK PGM2 CROT AGPAT3 FACL4 PRKAG2 AGL BMX ACACA PMC6664200__F3 Type I-IV mechanisms which aberrantly activate hedgehog pathway in cancer PTCH1 SHH SMO PMC6664200__F1 Diagrammatic representation of human hedgehog signaling pathway KIF7 SUFU PTCH1 SHH SMO GLI3 PMC7290932__F1 Diverse signalling pathways initiated by maturation initiation hormones (MIHs) lead to a universal biochemical core, activating maturation promoting factor (MPF) CDC2 ARPP19 MOS WEE1 MYT1 PMC2175514__F5 Transcription regulatory network indicates utilization of various transcription factors following activation of TLR7 IRAK1 IRAK2 IRF7 CCL5 IRAK4 CD44 COX2 CCR7 TRAF1 STAT4 TLR7 ISG15 TYK2 PMC6008129__F1 Potential mitochondrial derangements that may be present in pulmonary hypertension are many and varied UCP2 STAT3 TRPC3 PMC2175514__F9 Protein regulatory network indicates importance of ISGylation pathway in TLR7-mediated activation of pDC STAT1 SIAH2 UBE2D2 USP18 FGFR1 IRF3 TCF4 LYN JAK1 TRAF6 MAPK3 PMC9705782__F1 Differentially expressed tRNA-derived fragments in bovine fetuses with assisted reproduction induced congenital overgrowth syndrome AGO4 AGO1 AGO2 PMC6233321__F1 Ceramide pools and their metabolic connection CERS3 CERS5 CERK SMS CERS1 CERS2 CERS6 PMC3486512__F3 Network analysis of the host factors found to be associated with the extremities of the murine norovirus genome FUS GNL3 RSL1D1 CCT6A HEL-S-100n NCF1 HNRPR PABPC4 FARSLA PDCD6IP TLN1 EEF1A1 HNRNPK EIF2AK2 HSP90AB1 HNRNPAB HEL-S-72p DDX5 HNRNPD FASN TFG KHSRP EEF1G YBX1 PCBP1 ANXA1 PURB PTPN6 PABPC1 CSDE1 HNRNPF RPL23A HNRNPA2B1 KPNA3 PTBP1 RTN4 HNRNPUL2 EEF2 DDX3X RPL26 PMC6658873__F1 Synergistic effect of three combined strategies by targeting complement/C3aR /C5aR1/IL-10 pathway and other treatment modalities C5AR1 LAG3 PMC4164812__F1 BRAF inhibitors on melanoma and immune cells BRAF CCL2 PMC9134690__F3 Effect of berberine on global modulation of lncRNAs and mRNAs expression profiles in patients with stable coronary heart disease RAN EED HNRNPA0 PBX1 PRPF8 POLR2K PSMC1 PSMA2 SNRPF MED18 SALL4 SNRPE GRIP1 ATN1 CEBPB PDIA2 DDX5 POLL PSMD10 PCF11 PSMB8 USF1 UBE2M POLI RNMT SNRPN SNRNP200 NEDD8 CHD4 POLR2G PRPF31 AXIN1 DDIT3 HDAC9 EHMT1 RPS6KA3 PMC9091820__F2 Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons SOCS1 TBK1 CGAS MAVS TLR9 IRAK1 TRAF3 MYD88 STAT1 TLR4 TLR8 MX2 MX1 TLR7 OAS1 OAS2 STAT2 IRF9 IFITM1 IRF3 IRF7 OAS3 IRF8 TLR3 IFNAR2 IFNAR1 BCL2 TYK2 PMC3951427__F12 New miRNA Profiles Accurately Distinguish Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas from the Normal Kidney MADD EED PERP MYC PMC12025219__F3 Changes in bone metabolism caused by cold environment SOST FGF21 UCP1 RUNX2 PMC4567404__F1 A worm of one’s own: how helminths modulate host adipose tissue function and metabolism IL33 PMC6862705__F5 SPRY-altered signaling network profiles in mammary stromal fibroblasts RPS6 JUN PXN EIF4EBP1 ABL2 EGFR HEL-S-28 MAPK9 ARHA MAPK8 PPP2R5E HEL114 CRK TSC2 MAP2K4 PHLPP2 ERBB2 MAP2K2 SRC PIKFYVE PMC1756898__F1 Unraveling the Genetics of Human Obesity LEPR POMC MC4R NPY AgRP BDNF GHR PMC11814453__F4 The mechanism by which sodium channel inhibition exerts anti-tumor effects IRF3 MTOR SRC PMC11814453__F2 High salt or sodium ions on immune cells in the tumor microenvironment NLRC4 STAT3 NOS2 LTA NLRP3 TLR4 BATF3 ARG1 MTOR PMC6770497__F8 Key metabolic pathway and regulatory network in mutant ptsd1 CAD AMT GDA PMC9141700__F3 Metabolite and Gene Expression Analysis Underlying Temporal and Spatial Accumulation of Pentacyclic Triterpenoids in Jujube IPP MVD MVK PMC5885413__F3 LncRNAs regulate Rho/ROCK signaling in cancer metastasis CDC42 TIAM1 MMP2 ARHA RAC1 PMC5081730__F1 Epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling pathway BMP15 EREG EGFR BTC AREG GDF9 PMC3410320__F1 Survival and proliferative effects of Dilong extract on RSC96 Schwann cell EGF NGF GDNF IGF1 PCNA PLG BDNF PMC10866157__F6 Schematic diagram depicting the mechanisms of 5-aza-dC treatment in inhibiting choroidal neovascularization in a laser-induced mouse model APC NOTUM AXIN1 LRP5 LRP6 CCND1 LEF1 AXIN2 PMC5864536__F1 Estradiol and the Control of Feeding Behavior NTS TRH CCK CRH POMC NPY AgRP PMC2650609__F6 Top network of upregulated genes in quadriceps muscles of COPD patients, compared with control subjects UCP2 SLC16A3 FHL3 ALDH2 HEL113 SH3BP5 FOXO1 FOXO3A KLF9 G0S2 PMC4393798__F3 Overcoming T cell exhaustion in infection and cancer ZAP70 BATF APC LCK PMC9369298__F3 diaPASEF Proteomics and Feature Selection for the Description of Sputum Proteome Profiles in a Cohort of Different Subtypes of Lung Cancer Patients and Controls VWF CD59 FH CPB2 HEL-S-62p PLG F7 CR2 F11 CS CR1 C2 F2 F10 F3 A2M F8 PMC5457689__F6 Apoptosis pathway HTRA2 CAD ATF4 PMC3928643__F4 IL-12 centred network analysis IFNG TGFB1 IL12A TLR4 IL12B PMC3928643__F3 IFNA/B and IL-4 centred pathway analysis CD40 IFNG CCL3 IL2RG IL4 GIP PMC9704719__F6 Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation AHR SLC7A5 PMC7004522__F8 Working model shows that MET inhibitor inhibited the positive feedback loop between high STMN1 hepatocellular carcinoma (HCC) cells and hepatic stellate cells (HSC) HGF PMC11674327__F1 Extra-ribosomal functions of two RPs activating the NF-kB pathway during viral infection SMARCA5 RPSA RPL13 PMC5485730__F2 Interferon (IFN) type 1 signaling; regulation by methylation PRMT1 JMJD6 STAT1 STAT2 IFNAR2 IRF9 IFNAR1 PIAS1 JAK1 TYK2 PMC11933101__F1 Pyruvate synthesis pathway XK XDH PMC6331187__F8 The mechanism of celastrol in TGFB/Smad signaling pathway TGFBR2 SMAD2 SMAD4 TGFBR1 PMC5347564__F1 Hippo signaling pathway is the only pathway enriched with up-regulated DEGs EGFR APP CIT PMC9119001__F3 Metabolic engineering of microorganisms for L-alanine production AIDA PMC5407986__F2 Mitochondrial Control of Innate Immunity and Inflammation TRIM14 TBK1 TRADD MAVS TANK IRF3 PCBP1 IRF7 TRAF3 TRAF6 HEL-S-276 NLRX1 PC UBXN1 SMURF2 TRAF2 PMC5407986__F1 Mitochondrial Control of Innate Immunity and Inflammation STAT1 MAVS STAT2 IFNAR1 IRF3 IRF7 PMC3206369__F1 Primary phosphatases function as tumor suppressors and their signaling pathways RHEB TSC2 INPP4B PI3 PTEN MTOR CTNNB1 PMC6321995__F2 Therapeutic strategy for downregulation of excess inflammatory mucus to normal physiological mucus levels, using a small-molecule kinase inhibitor of MAPK13 CLCA1 MUC5AC MAPK13 APC PMC7646980__F10 Anti-inflammatory effects of BBR on LPS-induced inflammation via suppression of the TLR4/NFKB and MAPK/AP-1 pathways ECSIT MAL CD14 SIGIRR IRAK1 IRAK2 TNF TRAF6 IRAK4 MYD88 MAP3K7IP1 COX2 TLR4 IL1B PMC8739177__F1 Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF POR CREM SPG20 PMC8739177__F3 Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF CYP1A2 BAX ABCC1 CYP17A1 KIT TYMS MMP9 ACACA IL6 CYP1B1 TNF SHBG CYP2C19 NR3A2 ADRA2C HSD17B2 MMP2 AHR IL2 KDR CYP3A4 RET PMC5996447__F8 Hei-Gu-Teng Zhuifenghuoluo granule and the IL-12 signaling pathway IL16 STAT4 IL1B IL12RB1 PMC9219782__F1 Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men TBK1 TRADD MLKL OTULIN TNF RIPK3 GSDMD MAP3K7IP1 CASP3 RIPK1 TRAF2 CYLD FADD PMC4470863__F2 Commitment and maintenance of gonadal cell fate FOXI2 FOXL2 SOX9 SRY FGF9 WNT4 RSPO1 PMC8739177__F4 Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF SHBG NR3A2 MMP2 ERBB2 AHR IL6 KDR MMP9 ACACA CYP1A1 CYP3A4 TNF PMC4112160__F2 Surviving Change: The Metabolic Journey of Hematopoietic Stem Cells TSC2 TSC1 PTEN MTOR PMC5412370__F1 Specific elements of the canonical pathway for modulation of gene expression that are activated after 15 min of exposure of U118MG cells to 25 µM of PK 11195, as uncovered by “Regulator Effects” analytic (IPA®) WNK1 EGF NGF BAD FOXO3A EGFR LIF SRC SH2D2A MYC PMC3247990__F8 Post-induction repression of IFNB expression by YY1 in TLR3 signaling pathway TBK1 TLR3 RELB IRF3 IRF7 YY1 PMC6325472__F1 PI3K pathway activation and cell-cycle in tumor cells CDK6 CSH2 C2 PI3 GSK3B PTEN CDK4 PMC2835907__F3 Synopsis of FGFR2b-mediated dermal-epithelial signaling in keratinocytes and sebocytes of sebaceous glands FGF7 EGF IGF1 EGFR SHH IGF1R FGF10 CCND1 PMC2735462__F3 Ubiquitin in NFKB Signaling MAVS TRADD TANK IRF3 CYLD PMC3148288__F1 ERM proteins are scaffolds for cAMP signaling pathways ARF6 CSK LCK PMC9092946__F1 Endoplasmic Reticulum Stress and Its Role in Homeostasis and Immunity of Central and Peripheral Neurons GSDMD NLRP3 IRF3 HIF1A ATF4 EIF2A MYC IL1B PMC3109512__F3 Proposed role of CnPlc1 in pathogenicity-related signaling in C NRG1 CS GPR4 PMC7319438__F1 SPEED2 application We manually selected pathway-specific perturbation experiments and estimated their pathway-relevance HBEGF MCL1 IER2 PHLDA2 PMC3922094__F2 Pancreatic cancer pathway diagram EGF TGFA PTEN KRAS PMC9682072__F3 Viral tropism for the testis and sexual transmission SOCS1 CGAS TLR3 TLR4 TLR5 IRF3 MX1 ISG15 CXCL10 MYD88 PMC8558658__F7 Hey1 promotes migration and invasion of melanoma cells via GRB2/PI3K/AKT signaling cascade GRB2 PMC6983753__F5 Likely pathogenic mutations restricted in the metastases affect DNA methylation and transcriptional repression signaling pathway SAP130 DNMT3B SIN3A MTA2 MTA3 CHD3 RBBP7 CHD4 SAP30 RBBP4 SAP18 MBD3 MBD2 PMC6803376__F5 In the presence of the Ter mutation in Dnd1, members of mTOR, Hippo and Bmp/Nodal pathways have altered expression, with some transcripts indicated as direct targets of DND1 RPTOR SMAD1 SGK1 AKT3 SMAD4 PTEN NODAL MTOR RHEB TSC2 RICTOR TSC1 AMOT CRIPTO YWHAG PMC1557712__F2 Molecular control of alveolar morphogenesis TF SOCS1 TGFB1 ERBB4 PGR CEND1 SOCS2 EIF5 WNT4 ELF5 IGF2 CTNNB1 PMC2346559__F1 An Allosteric Mechanism for Switching between Parallel Tracks in Mammalian Sulfur Metabolism MGA HEL-S-182mP HEL-S-61p PMC9630750__F2 Drosophila melanogaster as a model to study innate immune memory ATF2 REL FADD MYD88 PMC2716801__F1 Schematic illustration of the Warburg effect in tumor cells and in early asymptomatic endothelial cell dysfunction ECHS1 TIGAR PMC6034857__F5 Transcriptome study on Macrobrachium nipponense hepatopancreas experimentally challenged with white spot syndrome virus (WSSV) CD36 VAMP3 CD14 TUBB MPO HEL-S-99n RILP LOX MARCOL TLR4 STX18 STX7 M6PR PMC8705789__F3 The Inflammatory Response in Mediating Functional Recovery Following Composite Tissue Injuries PTEN CTLA4 MTOR PMC10308199__F3 Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes CDO1 pcap SUOX PMC4163898__F1 Stress-induced premature senescence (SIPS) signaling pathway ATR CDK6 ATM MDM2 CDK4 PMC10380929__F3 PINNet: a deep neural network with pathway prior knowledge for Alzheimer's disease GATA2 MYB PIK3CA RAF1 CYCS MYC FLNA FGFR2 SMO MDH2 GGPS1 GOT2 SNCA ALDH3A2 TCF7L2 PAFAH1B1 SOS2 EDN1 PLCB1 DGKE HLA-A FGF13 HLA-DOB LEP CRH NR1C2 AOC2 ABCA1 PRKCB PLEK HLA-DRA CLU IL18 NOD2 APP HLA-DMB THBS1 LRRK2 CTH KIT ANXA1 TCF7L1 ARHA KRAS DDC ARAF ACVR1 IKBKB EP300 LYN NFATC3 BCL6 ADA CD40 SYK HK3 SLC17A7 NR4A3 PPP3CA PRKAA1 POR GNAS MARS2 HLA-E ANGPT1 RPA3 SRC HDAC2 P2RX7 BMPR2 FZD2 HK2 HLA-DQA1 HEL-S-28 HRAS GHSR CDK2 CDC42 HGF ATP2A2 RARA PRKCE ATM ITPR2 CACNB3 PLCB3 PFKM JUP BAX PTPN11 ATP1A1 EPHA4 MMP9 PTPRG NFKB1 RELA NFE2L2 MAP2K1 PFKL PMC8261290__F3 Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti NPC2 HEL-S-5 MYD88 PMC10992626__F2 Simplified illustration showing key pathways involved in disc degeneration ACAN STAT3 ADAMTS4 ADAMTS5 SDC4 TNF PMC9221885__F1 New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer’s Disease and Its Potential for Therapeutic Intervention TREM2 CGAS NLRP3 APOE IRF3 MTOR PMC8970588__F8 Simplified model showing how availability of the dedicated chaperone Rrb1 or Acl4 and the here uncovered regulatory network cooperate to balance Rpl3 and Rpl4 expression by co-translationally regulating RPL3 and RPL4 mRNA levels RPL3 RPL4 CA14 PMC3103989__F1 Endocrine, paracrine and autocrine regulation of the IGF-1R pathway and therapeutic strategies for its disruption IGF2R GHRH PTEN IGF1R MTOR SHE PMC8656811__F3 Genome Instability in Multiple Myeloma: Facts and Factors HMGB1 BACH2 BCR FOXO1 PAX5 RAG2 RAG1 IRF4 XBP1 BCL6 PMC10037588__F6 Reassessing the Abundance of miRNAs in the Human Pancreas and Rodent Cell Lines and Its Implication RHEB TSC2 BAD FAS CBL INSR POC1A FOXO1 GRB2 INS EIF4E PMC6071487__F2 Interleukin 6 (IL-6) receptor-mediated signaling pathway and an IL-6 inhibitor, the humanized anti-IL-6 receptor antibody tocilizumab SOCS1 STAT3 CD5 SOCS3 PMC6071487__F3 Arid5a stabilizes interleukin 6 (IL-6) and Stat3 messenger RNAs (mRNAs) STAT3 ARID5A PYY TLR4 MYD88 PMC9623116__F4 Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential BAX SYK BTK ORAI1 BCR STIM1 BLNK MCU PMC4484611__F6 Cell adhesion molecules (CAMs) pathway PTPRM CD226 CD40 CD80 NRCAM CD36 ELL CD22 PTPRC CD99 JAM2 CD58 CD9 CNTN2 CDH4 CD6 CDH2 ICAM2 CD2 ESAM MPZ SELL SELE APC CTLA4 ICOS ITGAM PTPRE PMC11694080__F7 Fluxes of glycolysis, pentose phosphate, and TCA cycle pathways in hMφ treated with DETA‐NO and CK RP1 GLDC RPE ADM PC PMC4872639__F8 Gq-dependent signalling by the lysophosphatidic acid receptor LPA3 in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA LPA ARHA RHO PMC3954954__F6 Tissue Factor Inflammatory Response Regulated by Promoter Genotype and p38 MAPK in Neonatal vs. Adult Microvascular Endothelial Cells TF STAT3 EGR1 SP1 TRADD PMC8465200__F1 Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review NR1i1 CYP2R1 DBP CYP24A1 CASR CYP27B1 RXRA DHCR7 PTH CYP3A4 CUBN CYP27A1 RXRB PMC7216841__F1 Latency reversing agents induce HIV‐1 provirus replication by diverse mechanisms BRD4 MEPCE LARP7 PTEN CS CDK9 PMC3406727__F1 Simplified schematic drawing of metabolic pathways in Chlamydomonas reinhardtii (adapted from Ref C6 HEL-S-62p C2 PMC5927619__F2 Pathway diagram for IL-2 family signaling showing the increase in detail level as zoom level increases RHOU SYK MATK SRC PMC5927619__F1 Enhanced high-level diagram (EHLD) for signaling by interleukins STAT3 STAT1 IL10 SHC1 SOS1 JAK3 IL18 PTPN11 GRB2 TRAF6 TYK2 PMC5758399__F2 Top section: Mechanisms responsible for the cytoprotective and anti‐inflammatory effects of PARP inhibitors on non‐oncological diseases PNKP DDB2 JUN RNF146 PARG APLF GSK3B CCL5 CCL2 SSB FOS CTNNB1 PMC5453942__F3 Map of DEGs in Oncopig leiomyosarcomas and their functions within the TP53 signaling pathway ATR FAS GADD45G CD82 CYCS SFN PMAIP1 CCNB3 GTSE1 CDKN2A CCND2 GADD45B RRM2B MDM2 CCNB1 CCND1 APAF1 BAX CASP9 THBS1 PERP CDKN1A SESN3 CASP3 SESN1 PMC2410298__F1 TOLL-LIKE RECEPTORS REGULATION OF VIRAL INFECTION AND DISEASE TLR1 MAVS TLR3 TLR4 TLR9 TLR7 PMC5453942__F4 Map of DEGs in Oncopig STS cell lines and their functions within the TP53 signaling pathway GADD45G PERP SFN PTEN MTOR PMAIP1 CCNB3 CDKN2A GTSE1 CDK6 IGF1 CDKN1A STEAP3 CASP3 SESN1 MDM2 CCNB1 CCND1 PMC9623116__F1 Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential STIM2 STIM1 MCU PMC4236713__F8 TBB through the non-mevalonate pathway and gene annotation in T IPP MAL CIT PMC11354688__F5 Process of human steroidogenesis HSD3B2 STAR CYP17A1 CYP11A1 HSD11B2 HSD17B1 HSD17B2 HSD11B1 PMC5352388__F7 N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways CDH2 MMP7 MMP14 MMP2 MMP9 CCND1 PMC7611845__F1 Driver pathways in the pathogenesis of marginal zone lymphoma SYK CARD11 IRAK1 BLNK CD19 MTOR NOTCH2 TRAF6 IRAK4 MYD88 BTK BCL10 BCR LYN PMC2944186__F1 Convergence between Wnt and EGFR pathways TGFA EGFR NKD2 LRP5 LRP6 CTNNB1 PMC8074257__F4 Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers RPS6 TSC2 TSC1 GC PTEN PMC4918710__F1 Alternate complement pathway C6 C7 HEL-S-62p CFI CFD CFH C9 THBD PMC4760064__F3 Gene regulation by peroxisome proliferators (PPARs): the most significant pathway from Crohn’s disease (CD) TF JUN SP1 CCL3 CYCS LDLR IL6 FOS PMC8074257__F1 Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers STAT3 FOXO1 PTEN SOCS3 MTOR SH2B1 PMC2891948__F2 Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens DRD1 CDK5 DRD2 BDNF PMC7395869__F1 Means to inhibit canonical HH, WNT and NOTCH pathways PORCN SUFU PTCH1 SMO CTNNB1 PMC7905009__F3 Scheme representing the different regenerative processes promoted by TGFB/activin signaling TBR1 TGFB1 MMP12 SMAD2 SOX2 TGIF1 PMC6605064__F1 Schematic diagram illustrating the UPR signal transduction pathway TCHP BCL2 ATF4 EIF2A XBP1 CP PMC6391951__F11 Illustration of most of the proposed modes of action of antitumoral POMs BAX VEGFA NDP PMC7810549__F9 Xiaoyaosan exerts its antidepressive effects in rats with chronic restraint-induced stress via regulating the activation of the immunoinflammatory response induced by the TLR4/NLRP3 inflammasome signaling pathway in the colon NLRP3 TLR4 TRAF6 PMC8546956__F7 Comparative phenotypic and transcriptomic analyses unravel conserved and distinct mechanisms underlying shade avoidance syndrome in Brassicaceae vegetables KL PC CS KDR PMC8128982__F4 Depicting the proposed pathogenesis of MIS-C with COVID-19 (the proposed pathogenesis is a constellation of various hypotheses referred accordingly) CD244 P2RX4 IRF3 VEGFA TNF MUC15 IFNGR2 CCL28 ECE2 CLEC14A PDC MUC4 CCL20 PMC3997957__F1 Cell cycle arrest by CDKN2A CDC2 CDKN2A MDM2 CDK4 PMC6445394__F1 RIG-I, MDA5, LGP2, PKR, and TLRs3/7/8 are activated during viral infection in the presence of non-self dsRNA TBK1 STAT1 ADAR MAVS TLR3 STAT2 USP18 IRF3 TLR7 FADD MYD88 PMC6651977__F1 The ER stress pathway RYR2 ATF4 EIF2A XBP1 WFS1 PMC9251145__F9 Salvianolic Acid B Attenuates Iopromide-Induced Renal Tubular Epithelial Cell Injury by Inhibiting the TLR4/NFKB/NLRP3 Signaling Pathway BAX NLRP3 IL16 TLR4 RELA REL MYD88 PMC8466696__F3 Comparison of the transcriptome in circulating leukocytes in early lactation between primiparous and multiparous cows provides evidence for age-related changes G6PC3 PGAM1 HEL-S-133P HEL-S-68p ALDH3A1 PGM2 HEL-S-162eP ADPGK HEL-S-30 PCK1 PFKM ACSS1 PMC9462548__F1 The JNK Pathway in Bladder Cancer BAX BAD MTOR SRC ATG5 PMC5572386__F2 Apoptotic and necroptotic mechanisms BAX CAD TRADD MLKL BCL2 CYLD TRAF2 FADD PMC3098789__F6 Portion of the 'Toll-like Receptor Signaling' pathway for two representative cell lines CASP8 TLR9 FADD PMC2593566__F3 JAK/STAT signaling pathway and SARS-CoV STAT1 STAT2 IRF9 JAK1 PMC10452461__F2 Fusobacterium affects chemotherapy drugs TLR4 MYD88 PMC4986142__F1 Resistance to RAF inhibitors NF1 BRAF PTEN GRB2 PMC5959917__F6 Schematic diagram explaining the mechanism of CSC maintenance in cervical cancer via let-7i-5p, miR-181a-2-3p and EGF/PI3K/SOX2 axis EGF HMGA2 EGFR SOX2 MTOR PMC7424006__F10 TLR4 had an important proatherogenic role in monocytes/macrophages TIRAP TLR4 VCAM1 TRAF6 MYD88 PMC4997609__F6 Wedelolactone enhances osteoblastogenesis by regulating Wnt/Beta-catenin signaling pathway but suppresses osteoclastogenesis by NFKB/c-fos/NFATc1 pathway GSK3B NFATC1 RUNX2 CTNNB1 PMC4724343__F3 Because KAT2B is a novel genetic susceptibility factor for drug abuse, we built a GeneMANIA () network centered around KAT2B to find related genes that may have functional links to drug abuse BMS1 SMAD1 USF1 TCF3 MAML1 CREBBP SNW1 EP300 TAF1B MDM2 NOTCH3 MAML2 KAT2B PMC8112447__F4 Zebrafish Cancer Predisposition Models TF HRAS CBL SOS1 NF1 GRB2 MTOR PMC8112447__F3 Zebrafish Cancer Predisposition Models RHEB TSC2 TSC1 APC GSK3B LRP5 LRP6 PTEN MTOR CTNNB1 PMC7697917__F11 Enrichment of the neuroinflammatory pathway in microglia in cluster 1, based on the DEGs between cluster 1 and clusters 2–5 CRP IFNE IL34 IL4 IRF7 CS IL6 TNF PMC8226020__F5 Calcium Binding Protein S100A11 and Its Roles in Diseases HEL-S-43 SMAD2 SMAD4 CTNNB1 PMC9149100__F7 Figure 3.Effect of CDK4 and CDK6 inhibition upon tumour cell-intrinsic and -extrinsic signalling pathways RHEB TSC2 RICTOR CDK6 CDK2 MTOR CDK4 PMC8112447__F7 Zebrafish Cancer Predisposition Models ERCC1 TOPBP1 ATR RAD51 BRCA2 TRAIP FANCM FAN1 FANCD2 RAD51C REV1 BRCA1 ATM SLX4 PMC7071697__F3 Complex mechanisms and signaling pathways underlying VM formation SMAD2 GSK3B ZEB2 PMC9149100__F1 CDK4 and CDK6 pathway in cancer CDK6 CDK2 CDKN2B CCND1 TOP2A CDK4 CTNNB1 PMC3108692__F1 Mammalian target of rapamycin (mTOR) network RHEB MLST8 TSC2 TSC1 PTEN MTOR PMC9420941__F4 Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases KEAP1 NQO1 GPX1 PMC9420941__F5 Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases LATS1 FGF8A TAOK1 TAOK2 LATS2 INF2 AMOT FGFR4 TAOK3 AJUBA RHO PMC5391240__F5 MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targeting SMAD4, FRAT1 and BCL2 FRAT1 SMAD2 APC GSK3B BCL2 CTNNB1 PMC4662480__F6 Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma STAT3 SRC TYK2 PMC11743736__F1 Lipid metabolism pathways and promising targets for breast cancer treatment ACLY LPL FAS HMGCR SQLE LDLR PC ACCS CPT2 PMC4055918__F1 Erythroid DAMPs drive inflammation in SCD DNASE1 TLR4 CD163 PMC5620554__F2 TRIMs in cytokine signaling STAT3 TRIM38 TRADD STAT2 TAB3 IRAK1 MYD88 STAT1 TRIM28 TRIM24 TRIM8 TRIM6 JAK1 TRAF2 TYK2 PMC6175656__F3 TRPCing around the Hypothalamus POMC SOCS3 PMC5000685__F2 Diagram of LPS-induced TLR4 signaling ECSIT TLR4 CD14 IRAK2 TRAF6 LBP IRAK4 MYD88 PMC3691765__F1 Apoptotic signaling pathways FAS CAD FADD PMC3691765__F4 HTLV-1 and apoptotic signaling pathways BAX BAD PMC8351892__F1 Tracing the roots of CLPD-NK by TET2 and STAT3 STAT3 TET2 PMC3983582__F2 Nucleotide excision repair (NER): the proteins associated with human diseases are highlighted ERCC1 PCNA XPC PMC2645908__F5 Model showing RBR3 role in the RBR/E2F pathway controlling the expression of MCM2–7 genes, DNA replication, and cell transformation MCM7 MCM3 MCM5 MCM6 MCM2 PMC12110399__F3 LGR5 potentiates the WNT–Beta-catenin signaling pathway that maintains the stem-cell-like phenotype, impeding cellular differentiation RNF43 LRP5 ZNRF3 LRP6 GPR49 PMC9579211__F3 Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways RHEB TSC2 PTEN MTOR PMC5753667__F2 The mammalian polyamine pathway SMS SRM SMOX PAOX PMC10521506__F10 Milk thistle nano-micelle formulation promotes cell cycle arrest and apoptosis in hepatocellular carcinoma cells through modulating miR-155-3p /SOCS2 /PHLDA1 signaling axis BAX SOCS2 PHLDA1 PMC9579211__F4 Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways HEL25 PMC9579211__F6 Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways ADAM17 ADAM10 NTM PMC5150411__F1 Metabolic pathways expressed in the deep subsurface HEL107 RPE CAD HPR HEL-S-162eP HBD GCK MTR PMC9389535__F2 Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota IFNG CD80 TSLP IL18 TNF PMC9175089__F6 Polyisoprenylated Cysteinyl Amide Inhibitors: A Novel Approach to Controlling Cancers with Hyperactive Growth Signaling CDC42 EGF ARHA KRAS RAC1 PMC4304082__F2 Piece #2: The BCL-2 family controls BAK/BAX activation and MOMP BAX BAD PMC4304082__F1 Piece #1: Tumor suppressor and oncogenic pathways converge on the mitochondrial pathway of apoptosis CASP9 PTEN MDM2 MYC PMC6407368__F2 Ca2+signaling pathways in Beta-cells DYRK1A SIK2 GSK3B CRTC2 PMC6398521__F4 Effect of 1,25(OH)2D3 and AB on the key reactions involved in the sphingolipid metabolic pathway CERS3 CERS5 CERK CERS1 CERS2 GC CERS6 PMC6662982__F8 In metabolic syndrome, hyperglycemia, and hyperlipidemia cause nutrient overinflux to kidney cells leading to increased celllular metabolism, which elevates intracelluar levels of citrate and ATP FAS HMGCR CD36 TNF PMC10478980__F4 Process of apoptosis BAX FAS TRADD BCL2 TNF APAF1 FADD PMC3444148__F1 Nodal signaling pathway in melanoma SMAD4 GSC NODAL PMC3304012__F3 Landscape of EGFR Signaling Network in Human Cancers: Biology and Therapeutic Response in Relation to Receptor Subcellular Locations EGF EGFR COX11 PMC10478980__F1 Process of necroptosis RIPK3 RIPK2 TRADD NLRP3 MLKL TLR4 RIPK1 TNF TRAF2 FADD PMC8945338__F3 Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway MOB1A MOBKL1A OSM OPA1 FOXO3A MX1 NF2 YAP1 CTNNB1 PMC7655915__F7 Proposed model of the stimulatory effect of growth differentiation factor 8 (GDF8) on relative transwell cells in human trophoblast cells FSTL3 SMAD2 SMAD4 PMC5485291__F2 MTOR signaling pathway and the possibility of curcumin's pharmacological action on the pathway in the treatment of SCI RHEB MLST8 TSC2 RICTOR PTEN MTOR EIF4E PMC8945338__F2 Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway LATS1 LATS2 SOX2 APP PITX2 YAP1 CTNNB1 PMC5888808__F1 Programmed death-ligand 1 (PD-L1) is the ligand of programmed death 1 (PD-1) receptor STAT3 IRF2BP2 PSMB8 EGFR MTOR YAP1 IFNG STAT1 CDK5 ALK IRF2 JAK1 SRC PMC4809260__F2 Oxidative stress under ambient and physiological oxygen tension in tissue culture BAX KEAP1 TLR4 RELA ATF2 PMC4188627__F3 Methamphetamine Alters the Normal Progression by Inducing Cell Cycle Arrest in Astrocytes RAD21 COMP MALL DNA2 PCNA CDK2 ME1 CA14 PMC3565254__F2 Pathways involved in endocrine resistance HBEGF SP1 EGFR SRC PMC11172744__F7 After TCR stimulation, two signaling pathways are induced via 3,4,5-triphosphate (IP3) and diacylglycerol (DAG) ZAP70 PLCG1 GPD2 LAT ADPGK PMC3335396__F1 Ligand-dependent activation of the Hh pathway PTCH1 SHH SMO PMC9350412__F7 SARS‐CoV‐2 ORF10 antagonizes STING‐dependent interferon activation and autophagy TH TBK1 CGAS IRF3 ACE2 PMC3385714__F3 Paralvinella conceptual glutathione pathway and responses to thermal exposure PALM HEL-75 PMC2180215__F1 Comparison of the protein kinase/phosphatase signaling pathways in flies, worms, and humans (see text for description) CDC42 ZAP70 SYK PTEN HEL70 GRB2 SRC LCK MYD88 PMC8316205__F5 Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis FKBP4 EGF TOB1 HOXA10 PGRMC2 FOXA2 HOXA11 PGRMC1 PMC8960399__F2 Proposed signaling pathways underlying the antidepressant-like actions of arketamine and TGFB1 TGFBR2 BDNF TGFBR1 PMC7758413__F5 Gene function network revealed a core role of the AP-1 linked signaling pathways during the recovery of COVID-19 SOCS1 JUN PIK3R1 HIF1A CXCL2 SOCS3 TNF CXCL8 SET RORA IFNG CXCR1 IL8RB CXCR4 CCR1 PMC8105091__F9 Mogroside V Alleviates Lipopolysaccharide-Induced Neuroinflammation via Inhibition of TLR4-MyD88 and Activation of AKT/AMPK-Nrf2 Signaling Pathway GCLM TLR4 GCLC MYD88 PMC8026647__F4 Reconstructing directed transcriptional networks and master regulators in ccRCC QRFPR MMP14 CREB5 KCTD1 PLXNB1 DIRAS2 BNIP3 KDM4B ZNF232 HMOX1 PLEKHG4 FOXM1 ABCG1 DERL1 IQGAP3 RIT1 CLEC2D MUC1 AMFR BARX2 CDH2 TSPAN6 TRIP13 ABLIM3 AXL PLD2 PLEKHG3 KNTC2 EZH2 GIT2 PAQR7 ASF1A HSF4 MCM7 MAP3K1 SCARB1 ZNF44 ZNF608 ZNF320 EMX1 MCM5 ARRDC2 ALDH1A2 ZNF630 UHRF1 ARHGAP24 ASF1B PMC5366136__F5 Relationship between the nine DEGs in network 1 in the Jerseys DDT GIMAP4 TRAPPC9 GNG10 ETFB GIMAP8 LARS2 TMEM102 TRAPPC6B PMC5366136__F4 Relationship between 18 DEGs in network 1 in the Holsteins NR1H4 FOSL2 SLC20A1 DGAT2 TAF6 TBC1D8 ELOVL6 FGFR2 PMC5543131__F5 Differentially active pathways across pan-urologic genomic subtypes C6 KEAP1 HK3 HIF1A HEL-S-51e SHMT1 C9 HEL-S-32 MDH2 C7 HEL-S-133P HK2 LDHB PPM2C SDHD PDP2 RPE SDHB PDHA1 HEL-S-304 ENO3 RPIA HEL-S-68p OGDH HEL-S-49 PDC DLD ENO1 SDHC SDSL HEL107 ENO2 HEL-S-62p PDK2 LATS1 LATS2 SLC25A1 LDHD NF2 PFKM CCND1 FH ACO2 FASN ME1 PDK3 DLAT PDK4 C2 PFKP PGM2 HEL-S-162eP WWC1 PSAT1 PFKL HEL-S-87p PSPH PMC4894314__F1 Effect of HDACI on cell survival signaling pathway in hemorrhagic shock GSK3B PTEN CTNNB1 PMC6211728__F7 Phenethyl isothiocyanate activates leptin signaling and decreases food intake POMC NPY AgRP PMC4894314__F4 TLR4 signaling – a converged immune response pathway for hemorrhagic shock and septic shock TLR4 IRF3 MYD88 PMC5597045__F2 RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic-acid-based metabolites such as lipids SPHK1 HEL-S-5 SPI1 PMC5597045__F1 RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic-acid-based metabolites such as lipids FAT4 FAT1 FAT2 FAT3 PMC6283154__F6 Summarization of DDT pathway selection in spn1 strains REV1 RMI1 PMC4923130__F1 Glucocorticoid-mediated modulation of pro-inflammatory pathways IL16 TLR4 GC MYD88 PMC3587991__F1 P53 signaling pathway interacts with chromatin-remodeling factors in response to DNA damage HDAC1 EP400 BRCA1 SIRT1 PMC5564318__F3 Up and down-regulated metabolic proteins in PANC-1 cells FH ENO2 CS PMC3587991__F2 Chromatin-remodeling factors affect the cell cycle CHD4 STAG3 HK2 SMC3 ATM SMC1A PMC8286839__F7 Feedback inhibition arising from NFKB activation operates at all levels in the pathway CITED2 SIGIRR PMC8286839__F6 Canonical and non-canonical NFKB signalling pathways CAP2 BCL2L1 TRADD TLR4 RELB CAP1 TRAF2 PMC8279535__F3 Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena WNT10B FOXP3 TNF PMC10376369__F7 Alzheimer’s Disease and Green Tea: Epigallocatechin-3-Gallate as a Modulator of Inflammation and Oxidative Stress BAX MCL1 GSK3B PTEN PMC3188682__F3 TGFB1/SMAD3 signaling as an integrator of fibrotic mechanisms in the kidney KCP HGF USF2 EGFR BMP7 SRC SKI PMC10376369__F5 Alzheimer’s Disease and Green Tea: Epigallocatechin-3-Gallate as a Modulator of Inflammation and Oxidative Stress BAX BAD ECE1 GSK3B BDNF PMC3727840__F2 TGFB in bone metastasis: novel therapeutic perspectives CDC42 SMAD2 SMAD4 ARHA PMC4922502__F2 Actionable drugs in proliferation pathway that have been evaluated in BRAFmut CRC APC BRAF GRB2 MTOR CTNNB1 PMC8906035__F1 Kynurenine pathway in Coronavirus disease (COVID‐19): Potential role in prognosis IFNG IDO1 IL2 IL6 IDO2 PMC6530343__F2 Target sites of therapeutics along the pathogenetic pathway of celiac disease HLA-E GEM CCR3 MICA MICB TNF PMC6509151__F4 The role of FcμR in central deletion and B cell repertoire selection FCMR FOXO1 JCHAIN RAG1 PMC5718814__F2 Molecular mechanisms of DNA vaccines TBK1 TLR3 TLR9 AIM2 IRF3 IRF7 MYD88 PMC2754046__F1 Hypothetical schematic of a DAergic synapse TH DBH PMC6718713__F1 Microglial signaling pathways determining development of cells with divergent abilities NPS GDNF IKBKE PTEN MIF SOCS3 TNF IRAK4 NOX4 CNTF CCL21 NFKBIA JAK1 PMC7782086__F8 Graphical abstract illustrates the function and regulatory mechanism of FOXD1‐AS1 in AGS FOXD1 PIK3CA PI3 MTOR EIF4E PMC8381052__F4 Autoantibody-Specific Signalling in Pemphigus ERBIN PLCG1 SHOC2 DSG1 ARHA PMC8968138__F1 NTRK Fusion in Non-Small Cell Lung Cancer: Diagnosis, Therapy, and TRK Inhibitor Resistance TSC2 NGF BAD TSC1 GRB2 PMC7056923__F3 Lactate is a signaling molecule in cancer and endothelial cells NDRG3 EGFR MTOR PMC8448164__F3 Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action ERBB3 TSC2 BAD TSC1 EGFR ERBB2 IGF1R MTOR PMC8448164__F5 Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action APC LRP5 LRP6 CTNNB1 PMC8448164__F7 Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action TSC2 TSC1 MTOR PMC7887252__F8 Proteins/enzymes in this pathway regulate both calcification and atherosclerosis APOE ENTPD1 ENPP1 PMC10572708__F12 Lipid and atherosclerosis metabolic pathway CD40 STAT3 IDE BAX BAD TIRAP SELE TAB3 TANK CD14 IRF3 TNF MCEE LOX NOG CASP3 APOB LYN LBP SELP PMC3962153__F2 Products for which C HEL-S-162eP PDC NR1A2 PMC7835977__F6 Proposed mechanism by which GAT107 restores bacterial clearance in the lungs by reducing oxidative stress, due to hyperoxia KEAP1 HEL-S-44 PMC8301062__F2 GSK-3B in Pancreatic Cancer: Spotlight on 9-ING-41, Its Therapeutic Potential and Immune Modulatory Properties ATR GSK3B LAG3 PMC3404195__F6 Proposed regulatory mechanism of ERB in colitis-associated colon cancer IFNG STAT3 STAT1 MUC2 MUC1 JAK1 IL6R CTNNB1 PMC12124727__F3 Metabolomic analysis in QFA of WT, db/db and Mpst−/− mice PC PMC7438937__F5 Pathway enrichments of SHGS ADAR IGF2BP1 XRN1 LSM6 LSM1 DCP2 LSM3 LSM5 LSM7 SLBP LSM4 A1CF LSM2 PMC3313874__F2 Networks built using differentially expressed genes in uninfected macrophages from C57BL/6 and CBA mice PROX2 CADM1 GDF15 MT1E AGTRAP RSAD2 HLA-C EMB CTSC IL10RB PMC2689781__F7 Grade-dependent Proteomics Characterization of Kidney Cancer ADH1C PCK2 ALDOB ENO2 PFKP SUCLG2 FBP1 DLD ENO1 HEL-S-87p PMC9497807__F4 Polycomb Directed Cell Fate Decisions in Development and Cancer IL10 FAS CXCL13 IL2RA NUMB EZH2 MICA CXCL10 CCL2 GATA3 ID3 IFNG CCL24 FOXP3 CD163 CCL1 CCL17 PMC10341937__F2 Canonical Wnt signal transduction pathway APC GSK3B LRP5 LRP6 PMC9497807__F2 Polycomb Directed Cell Fate Decisions in Development and Cancer EZH1 SUZ12 CBX2 EPOP AEBP2 EZH2 JARID2 PMC4926062__F4 Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer EGF HBEGF BAD TGFA CYP2E1 COX2 BCL2 GRB2 MMP9 CCND1 RALBP1 PMC4926062__F2 Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer PPIC RBMX SRSF7 POLD3 SRRT PRMT3 WDR43 HEL-S-10 FAIM NCBP1 TMX3 PIM3 ARFGEF3 MT1M DDX39A GINS3 SLC67A1 ALYREF PNN dik PSPC1 PRIM2 RIF1 PRIM1 KCNK3 BARD1 MCMBP CRLF1 MCM10 SRSF6 GINS2 EIF3M MCM5 AK4 TRA2B MTCL2 CCDC55 PPM1D NT5DC2 CMSS1 NOL11 RAB31 EGFR DCLRE1B CLSPN SAFB2 HMGB3 EXO5 GINS4 CKAP2 KIFC2 LIN7C TRMT10C MIB2 KCTD9 OAS2 ERCC6L PLD3 GINS1 SMCHD1 PCF11 SFRS3 CHD3 HES4 WDHD1 GJC1 CLIP2 PMC6614175__F4 Antioxidant mechanism of the NRF2 pathway HMOX1 NOS2 KEAP1 SRXN1 PMC2976847__F1 Cytokines, hormones or growth factors that activate Stat5 EGF BAD OSM STAT5B EPO TPO PMC4826150__F1 Regulation of target genes by the Wnt/Beta-catenin asymmetry pathway SYS1 POP1 CTNNB1 PMC7437079__F3 STAT3 pathway and IL6/STAT3/S1PR1 amplification loop in IBD-CRC STAT3 S1PR1 IF2B1 SOCS3 IL6 PMC5739082__F1 Simplified schematic depicting the mTOR pathway and associated “mTORopathies.” The mTOR pathway involves 2 complexes, mTORC1 and mTORC2 RHEB TSC2 TSC1 EIF4E PMC7270529__F3 IPA’s individual pathway analysis of different proteins from the different experimental groups, linking them to a suggested promotion or inhibition of a cellular event under the umbrella of inhibition of cell death or change in cytoskeletal activity PRMT1 RAN HEL113 TCP1 ACSL3 PXN CS MYC STUB1 GNAS GDI1 ALOX5 HSP90AB1 PTGER2 SPTBN2 ANXA1 PTGS2 ARHA CHMP2B BRDT PHB2 ITGB1 RTN4 PBR PTGER4 PS1TP5BP1 TOMM70 PMC4697282__F1 Chemical disruption of Wnt-dependent cell fate decision-making mechanisms in cancer and regenerative medicine WLS LRP4 PORCN APC CTNNB1 PMC4697282__F2 Chemical disruption of Wnt-dependent cell fate decision-making mechanisms in cancer and regenerative medicine WLS PORCN TNKS PMC5466605__F9 Illustration of a proposed signaling pathway of innate and adaptive immune activation in the Nx model (A) CD40 CD80 TLR9 IRAK1 CCL5 TRAF6 MYD88 IFNG IL1R1 NLRP3 TLR4 NOD2 IL18 TLR7 IL1B JUN CASP8 CD14 TLR5 IRF3 IRF7 TNF CXCL10 MAP3K7IP1 LBP PMC11980037__F5 Downregulation of Tnf, Il1a, and Il1b in M2c macrophages exhibited immune tolerance in autoimmune diseases TLR4 APC IL21R FOXP3 PMC2676994__F1 Schematic model illustrating multiple signaling pathways in regulating StAR gene transcription EGF SP1 PRL PMC5593680__F3 Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials ACLY RHEB TSC2 FAS EGFR ATM MTOR EIF4E PMC4387772__F2 T Cell Energy Metabolism as a Controller of Cell Fate in Transplantation ICOS CD80 CD36 HEL-S-162eP ARG1 CTLA4 PMC4387772__F1 T Cell Energy Metabolism as a Controller of Cell Fate in Transplantation TSC2 TSC1 FOXO1 FOXO3A PTEN HIF1A CTLA4 FOXP3 MYC SIRT1 CIT PMC3193940__F2 An array of cellular stressors can perturb the folding environment in the endoplasmic reticulum (ER) leading to unfolded or misfolded protein BCL2 ATF4 EIF2A RCAN1 XBP1 TRAF2 PMC11980037__F3 KEGG disease pathways map analysis displays downregulated DEGs influenced by DEX-induced M2c macrophages involved in anti-allograft rejection CD40 IFNG CD80 APC TNF PMC8281885__F2 Chemoresistance and Metastasis in Breast Cancer Molecular Mechanisms and Novel Clinical Strategies LATS1 STAT3 LATS2 SUFU SMAD2 LRP5 SMAD4 LRP6 SMO MTOR CTNNB1 PMC3717802__F6 Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer RHEB GRB10 GIP IRS1 PMC7657570__F1 Androgens facilitate SARS-COV2 entry through a TMPRSS2-mediated pathway TMPRSS2 ACE2 PMC6817822__F9 PR55A regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells LATS1 LATS2 PMC8012676__F9 Proposed model for effect of GNE mutation on actin dynamics and cell migration GNE ARHA SRC PMC5627884__F9 Kyoto Encyclopedia of Genes and Genomes and TGFB signaling pathway with changes between adult facial fibroblasts and neonate fibroblasts denoted by color code BAMBI LTBP1 IFNG FST SMAD2 SMAD4 SKP1 NODAL ARHA PMC6547527__F8 a The Spearman correlation coefficient revealed the association between the changes of fermentation parameters and the expression of these eight growth-related genes (SCC > 0.85 and p < 0.01) MAPK1 SNAI2 BAD ITGA6 TNFSF10 PMC7040073__F5 Changes in the transcript abundance of genes involved in central metabolic pathways, fatty acid biosynthesis, and the PKS-NRPS pathway FAS KMO HEL-S-5 HAAO ENO1 PMC2945394__F1 Post-pandrial increase in insulin leads to induction of lipogenesis and inhibition of lipolysis LPL TG HEL-S-5 PMC6540047__F3A Transcriptomic Analysis Reveals Priming of The Host Antiviral Interferon Signaling Pathway by Bronchobini® Resulting in Balanced Immune Response to Rhinovirus Infection in Mouse Lung Tissue Slices GYPB IFNE IFNA6 MAVS IRF9 IF1AA9 TANK IFNA4 IRF3 ATF2 IFNA2 TRAF3 RERE AEN IFNG RIPK1 ISG15 FADD PMC8699551__F5 Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger ULK1 ATG5 PMC8699551__F3 Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger NBR1 TBK1 PINK1 ULK1 BAG4 SIRT3 BAG5 BAG2 BAG3 C2 MFN2 BCL2 BAG6 OPTN PMC8924168__F5 BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling TCF20 CHD2 SRSF7 SFRS18 SRRT BAD SHC1 THRAP3 RPS6KB2 PML CDYL TNS1 PRPF40A MTOR RPLP2 PNKP BACH1 CDK12 BCL10 RBM10 AEBP2 SP100 WAC RAD9A RPS17 UBAP2L IWS1 RPTOR NSUN2 RPLP0 FASN ACIN1 SCAF11 MDC1 BARD1 ARD1A BRCA1 GYS1 PLEC SSRP1 SRSF6 LIPE ERBB2 PRKAB2 HDAC7 MCM6 PMC8236093__F1 Lipid-Derived Mediators are Pivotal to Leukocyte and Lung Cell Responses in Sepsis and ARDS GPR37 FPR2 LGR6 PMC6712069__F1 An overview of Wnt signaling pathway JUN SOST RNF43 APC LRP5 ZNRF3 RYK RHO AXIN2 CTNNB1 PMC4881503__F1 EPO-induced intracellular signaling pathways Erythropoietin and its receptor signaling through JAK2 activate multiple downstream signaling molecules including STAT5, PI3K/Akt, NFKB, and MAPK BAD EPOR EPO PMC6459341__F7 HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1B STAT3 IL1R1 OSM IL6 IL1B PMC3920756__F6 Single Nucleotide Polymorphisms in MicroRNA Binding Sites of Oncogenes: Implications in Cancer and Pharmacogenomics APC MAL PMC5763539__F3 Pathway map for “LRRK2 and immune function in Parkinson’s disease” PSMD11 STAR FCGR3A IQGAP1 PMC7853124__F1 Immunopathobiology and therapeutic targets related to cytokines in liver diseases CXCL9 STAT1 IL2RB CXCL1 IL2RA STAT4 IL12RB1 PMC4587736__F1 Germinal Center Kinases SmKIN3 and SmKIN24 Are Associated with the Sordaria macrospora Striatin-Interacting Phosphatase and Kinase (STRIPAK) Complex LATS1 STRIP1 MOB2 STRIP2 MOB4 CTTNBP2 STK24 HEL70 GCK PMC7953864__F6 Signaling pathway of MBHD-VD PPI network (blue and pink circles stand for compound target and VP genes, resp; red diamond stands for pathway; green hexagon stands for herb) TF SYK JUN JUND LTA FAS CYCS MTOR NGF CBL NPY KDR SRC PMC8211386__F2 Cancer therapeutic approaches targeting apoptosis pathways BAX BAD DRD2 MCL1 CLPP ATF4 MDM2 KRAS FADD PMC8211386__F1 Apoptosis signaling pathways and pro-survival, immune, or tumor microenvironment influences that impact on them BAX ATR MCL1 PTEN MTOR CTLA4 MYC BCL2 RIPK1 ATM ATF4 APAF1 FADD PMC5763539__F4 Pathway map for “Inhibitory PD-1 signaling in T cells” POR SYK CDK2 PTEN VAV1 MTOR SKP2 PMC9220155__F3 Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation TFAM CGAS PINK1 NLRP3 KEAP1 TLR4 BACE1 TLR9 CEBPB PMC9448813__F2 Notch signaling pathway ADAM17 ADAM10 HES1 PMC9957752__F13 Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease HHIP FOXO1 PTCH1 SMO IRS1 PMC9220155__F4 Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation TFAM STAT3 CGAS NLRP3 KEAP1 NQO1 BACE1 TLR9 CP PMC6893479__F2 A summary of the main enzymes involved in the classic and alternative bile acid biosynthesis pathways CYP8B1 CYP7A1 CYP7B1 CYP27A1 PMC5411790__F1 Postulated interaction between enzastaurin and erlotinib in the EGFR pathway BAD PTEN GRB2 MTOR CCND1 PMC5004872__F7 Schematic showing proposed mechanism of ECM synthesis following CDH11 engagement CDH11 SMAD2 MYOCD RHO PMC6195642__F1 AKT/mTOR Signalling Pathway SYK CD79B CD79A GSK3B BLNK PTEN MTOR IRS1 EIF4E RHEB TSC2 BTK TSC1 FOXO1 BCR FOXO3A F3 LYN PMC8624812__F3 Probiotics Regulating Inflammation via NLRP3 Inflammasome Modulation: A Potential Therapeutic Approach for COVID-19 TMPRSS2 GSDMD NLRP3 ACE2 IL1B PMC3089878__F2 Cholesterol transport in the CNS VLDLR LDLR PC PMC5626616__F1 TNF-receptor superfamily agonists as molecular adjuvants for cancer vaccines CD27 APC BCL2 FOXP3 PMC3262099__F8 The host cell EGF signaling pathway and proteins downstream of the EGF receptor that are activated in response to C EGFR SRC RAC1 PMC8252888__F9 GEFT Inhibits Autophagy and Apoptosis in Rhabdomyosarcoma via Activation of the Rac1/Cdc42-mTOR Signaling Pathway CDC42 BAX MTOR PMC7057844__F2 Molecular Mechanism of Runx2-Dependent Bone Development PTHLH PTCH1 SP7 FGFR3 PTH1R RUNX2 FGFR2 PMC9436900__F4 PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities BAX BAD TLR4 PTEN PMC9436900__F2 PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities RIPK3 BAX TRADD MLKL ULK1 RIPK1 ULK2 FADD PMC12056481__F4 DUBs in Wnt/Beta-catenin pathway, MYC signaling pathway and Hippo pathway in HNSCC LATS1 APC USP22 LRP5 LRP6 EZH2 CTNNB1 PMC5384738__F4 Top networks and gene connections.Notes: Literature-based clustering of differentially expressed genes using Ingenuity Pathway Analysis (IPA) after 78 hours of 100 µM corilagin stimulation in SKOV3 cells HLA-DRA EGFR APP HEL-S-1 LYN PMC10474083__F1 Detailed kinetic model of glycolysis in Plasmodium falciparum-infected red blood cells for antimalarial drug target identification EN2 EN1 PMC12056481__F3 DUBs in the PI3K, TGFB and HIF-1A signaling pathway in HNSCC OTUD3 USP1 SMAD4 PTEN MTOR CYLD HEL-117 VHL PMC12056481__F2 DUBs in the p53 pathway, NFKB signaling pathway and RAS/RAF/MEK/ERK pathway in HNSCC USP28 USP4 EGFR MDM2 CYLD PMC11828970__F2 Simplified pathways of ammonia metabolism and treatment NAGS ASL OTC ORC1L PMC5864929__F4 Arachidonic Acid Metabolism Pathway LTA ALOX5 MAL PTGS1 PTGES ALOX15B ADA PMC7355739__F2 Modeling of the multiple functions of Reelin during migration, dendritic growth and synaptic development and the corresponding signaling pathways: (A,A’) CDC42 FBXO45 VLDLR MTOR VAMP7 SOCS7 CRK DAB1 NECTIN3 NECTIN1 GRIP1 SNAP25 ITSN1 CP PMC10516898__F15 Mechanism of D-TT-BMSCs inhibiting ferroptosis to repair the wound HMOX1 FTH1 BACH1 SLC40A1 GPX4 SLC7A11 PMC7986854__F7 MHC I antigen presentation pathway is down-regulated by multiple mechanisms in cancers MEX3C ALK STAT2 SPPL3 SND1 RET PMC5031610__F2 Current knowledge on the cell type/context-dependent regulation of Wnt/Beta-catenin signaling by NFKB pathway APC LEF1 PMC5306062__F2 Cell death induced by benzopyran compounds by minor chemical modifications of the benzopyran scaffold MTOR PMC5031610__F1 Current knowledge on the cell type/context-dependent regulation of NFKB signaling by Wnt/Beta-catenin pathway TNFRSF19 BTRC TLR4 APC PMC4630557__F2 Signaling pathways of main checkpoints molecules ZAP70 APC MTOR PMC4401268__F1A Dual role of Cav-1 Y14 phosphorylation: phosphorylat-ed caveolin (pYCav-1) is involved in the control of integrin-mediated signal transduction and caveolae-mediated cholesterol-enriched membrane microdomains (CEMM) endocy-tosis CSK RHO SRC PMC4801467__F1 Mechanisms and immunotherapeutic targets for glioblastoma (GBM) TBK1 IL10 IDO1 AHR IRF3 IRF7 FOXP3 PMC8199574__F3 Catecholaldehyde Hypothesis for the Pathogenesis of Catecholaminergic Neurodegeneration: What We Know and What We Do Not Know TH DBH PMC4322971__F3 Role of p53 in the progression of gastric cancer GC MDM2 PMC8301030__F10 Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans TH GC BMP2 CTSK NFATC1 RUNX2 PMC6657254__F1 Summary of the neuroprotective action of resveratrol BAX COX1 GSK3B SIRT1 PMC7990077__F5 Proposed mechanistic diagram of the multi-faceted, anti-neoplastic effects of GSE against lung cancer IGF2R PTGIS PTEN IGF2 PMC5864729__F6 Schematic summary of mechanisms underlying VRCZ-induced skin cancer AHR CYP1A1 PMC12202337__F3 The ERK signaling pathway in regulating remyelination CNTF NGF GDNF BDNF PMC8946840__F2 Mesothelin: An Immunotherapeutic Target beyond Solid Tumors STAT3 BAX BAD MSLN FOXO3A DKK1 CDK2 PMC6042636__F2 Sox2: regulation of expression and contribution to brain tumors TBR1 SUFU SMAD2 APC SOX2 SHH SMAD4 SMO PTEN CTNNB1 PMC5702855__F2 Multiple signaling pathways drive EMT in GBC cells CD44 CD24 APC GSK3B SHH SMO MTOR WIF1 CTNNB1 PMC2211634__F3 Models for the dual roles of KLF4 and KLF5 in tumor suppression and oncogenesis KLF4 BAX KLF5 PMC9220225__F2 2-Hydroxyglutarate in Acute Myeloid Leukemia: A Journey from Pathogenesis to Therapies KDM4A DEPTOR VHL PMC6407321__F4 Protection for oral SUB+IV vaccine against tick infestations in cattle TH HEL-S-62p IL16 IL1B PMC11387120__F3 Drug resistance mechanism of tumor immune microenvironment factors STAT3 CCL22 HIF1A JAK1 CCL8 PMC7779537__F8 Aberrant elevation of GDF8 impairs granulosa cell glucose metabolism via upregulating SERPINE1 expression in patients with PCOS SMAD2 SMAD4 PMC4185425__F3 The Programmed Death-1 Immune Suppressive Pathway: Barrier to Anti-Tumor Immunity CD80 APC CTLA4 PMC2613471__F1 Revisiting Notch in remyelination of multiple sclerosis lesions F3 NOTCH1 PMC10604135__F6 Mutated proteins in four patients colored with red, green, cyan, and brown with arrangements of their roles on Wnt and mTOR signaling pathways RPS6KA6 RPS6 TSC2 INTS6L TSC1 SUMF1 USP9X FLNA WIF1 PS1TP5BP1 CTNNB1 EIF4E PMC8698499__F12 Novel Insights into the Prognosis and Immunological Value of the SLC35A (Solute Carrier 35A) Family Genes in Human Breast Cancer MADD ATR CDC20 RASSF1 CDC6 APC ATM PLK1 SKP2 XBP1 PMC4185425__F1 Programmed Death-1 Immune Suppressive Pathway: Barrier to Anti-Tumor Immunity ZAP70 CD80 APC PC CTLA4 PMC4158833__F4 Shaping the mammalian auditory sensory organ by the planar cell polarity pathway DVL1 PTK7 PMC5187940__F3 Effect of Pb on the signaling pathway TLR4-MyD88-NFKB and the production of pro-inflammatory cytokines in microglial cells JUN ATF2 TRAF6 IRAK4 MYD88 PMC5136547__F1 Innate immune response against rotavirus in intestinal epithelial cells (IECs) JUN MAVS STAT2 RNASEL IRF3 TRAF3 CXCL10 TRAF6 FOS RAC1 STAT1 TLR3 JAK1 TYK2 PMC6891791__F4 Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol MAK SI PAH MTOR TNF PMC3677900__F5 Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells STAT3 EGF HGF EGFR PMC6891791__F6 Immune system pathways in KEGG pathway analysis TH FAS tal-1 CASP3 TNF PSCA FADD PMC6891791__F5 Nervous system pathways in KEGG pathway analysis ACHE BAX JUN MAPKAPK2 RELA NFKBIA NTRK2 APP ATF2 FOS IRS1 PMC9465410__F4 Exploring the mechanism of YangXue QingNao Wan based on network pharmacology in the treatment of Alzheimer’s disease APOE BACE1 APP PSEN1 PMC7395405__F4 Schematic diagram of signaling pathways in exosome-mediated autophagy inside target cell RHEB STAT3 TSC2 TSC1 EGFR PTEN MTOR PMC9019277__F1 Teaching an old dog new tricks: reactivated developmental signaling pathways regulate ABCB1 and chemoresistance in cancer PTCH1 SMAD4 SMO HIF1A PITX2 ABCB1 PMC7084677__F1 Canonical phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1)/Parkin pathway PINK1 PARL AMBRA1 PMC5837509__F2 Apoptosis and p53 signaling related to Cr(VI) exposure HTRA2 BAX BAD CAD MCL1 ROCK1 CYCS GAS2 BCL2 ATM HP DIABLO PMC3919568__F7 Integrated metabolic pathway of BCAA metabolism OXCT1 MLYCD ECHS1 HMGCL ACADSB PCCA DBT PCCB SLC7A5 ACADM MCEE ABAT ACAT1 HADHB OXCT2 MCCC2 BCAT2 DLD MCCC1 PMC3095763__F1 Toll-like receptor Signaling in Neural Plasticity and Disease STAT1 EGR1 STAT2 TLR4 CD14 IRF3 MMP9 MYD88 PMC9526834__F1 Dietary Patterns and Gut Microbiota: The Crucial Actors in Inflammatory Bowel Disease MLKL MTOR PMC4783780__F8 Response of Human Osteoblast to n-HA/PEEK—Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite GNGT1 PRKD1 GNG5 RGS16 GNG12 CHRM3 AMN RYR3 HEL-S-99n RGS7 KCNB1 HEL-S-1 HEL-S-11 NACA RYR2 RGS14 GNB2 PKIG RGS10 RGS11 RGS20 RGS6 ADCY3 ADRB2 CALM1 ADRB1 GNG7 RGS2 PLN GJA10 KCNJ5 GJB4 CXNA ADRA1A SFN ATP2A2 FXYD2 ADRB3 GNB1 KCNJ3 ADCY9 YWHAQ CASQ2 FKBP1A ITPR2 RGS1 CACNB3 PLCB3 CACNA1S HEL2 YWHAG CACNB1 PKIB GNB3 ARRB2 GNG4 GNG13 GJB2 GNG3 GJB1 GNG8 GNG2 RGS18 RGS17 GJA4 C2 CAMK2D GNB4 RGS4 PKIA GJB3 GJB6 GNG11 GJA1 CAMK2G YWHAZ PMC10252624__F1 Mechanisms of VEGF (receptor) inhibitors-induced cardiovascular complications VEGFB VEGFC VEGFA PMC11854354__F2 Signaling cascades generalized for ubiquitin-mediated IKK activation in IL-1R/TLR and TNF pathways SHARPIN TRADD TAB3 IRAK1 TRAF6 TNF OPTN TRAF2 IRAK4 MYD88 PMC3210079__F8 Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells SMAD1 EPHA4 NOTCH2 TWIST1 HES1 CTNNB1 PMC10239259__F2 Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy WWP1 KLF15 MTOR SAMD3 IRS1 PMC10252624__F2 Primary mechanisms of ICIs-associated cardiotoxicity APC CTLA4 PMC11854354__F3 Ubiquitin-mediated IKK activation and Bcl10 autophagy in the T cell signaling pathway ZAP70 BCL10 LCK PMC3830939__F2 Tudor: a versatile family of histone methylation ‘readers’ PHF19 SUZ12 POLL EED SGF29 POLI ATM EZH2 UHRF1 PMC9843448__F1 Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies STAT3 CXCL12 SMAD1 DKFZp781O1323 COX2 PDGFA FGFR1 NUPR1 VEGFA CXCR4 SOX4 FGF2 PMC11500076__F2 STING signaling in dendritic cells (DCs) CGAS IRF3 PMC6770861__F6 A Novel Tanshinone Analog Exerts Anti-Cancer Effects in Prostate Cancer by Inducing Cell Apoptosis, Arresting Cell Cycle at G2 Phase and Blocking Metastatic Ability BAX MMP9 CCNB1 PLK1 PMC11481725__F2 Protective role of brown adipose tissue in cardiac cell damage after myocardial infarction and heart failure EGR1 FGF21 SMAD2 MMP2 MMP9 PMC11481725__F1 Protective role of brown adipose tissue in cardiac cell damage after myocardial infarction and heart failure SMAD1 DKFZp781O1323 FGF21 PMC11500076__F1 STING signaling pathway TBK1 CGAS IRF3 PMC5361499__F1 Amyloid precursor protein (APP) processing.APP preferred processing is the non-amyloidogenic pathway which digests with Alpha-secretase followed Gamma-secretase and takes place at the plasma membrane (PM) TREM2 CLU SORL1 BIN1 PICALM PMC6175949__F8 Proposed positive feedback mechanism for Th17 cell-secreted IL-17A and NLRP3 inflammasome activity in a circuit NLRP1 NLRP3 IL16 IL1B PMC7452966__F1 Amino acid metabolism in pluripotency regulation GLDC PSAT1 ATF4 EIF2A PMC6560007__F1 MicroRNA biogenesis DGCR8 CCR4 DROSHA PMC6962107__F2 L-ornithine biosynthesis metabolic pathways in C HEL107 PTS PMC3694398__F5 NFAT Gene Family in Inflammation and Cancer COX2 IL4 NFATC1 IL11 CTNNB1 PMC4246949__F9 Scheme of the regulatory interactions connecting PREP1 and PBX1 expression with the TGFB–SMAD3 pathway, cellular invasion, and EMT JUN PBX1 PMC6914882__F10 Schematic representation influence of PCr against DCM on Bcl-2 family members and other mitochondrial apoptotic and metabolic proteins in cardiomyocytes under various pathological conditions STAT3 CASP9 CASP3 BCL2 PMC5053108__F7 Role of miR-9 in zebrafish brain development.Notes: (A) Zebrafish forebrain: In the forebrain, miR-9 inhibits proneural gene her6 and targets Fgf signaling pathway genes (dusp6, pea3) ELAVL3 FGFR1 ZIC5 FGF8 PMC8185021__F6 Cleavage of Syndecan-1 Promotes the Proliferation of the Basal-Like Breast Cancer Cell Line BT-549 Via Akt SUMOylation RHEB TSC2 MMP14 TSC1 MMP2 CS SDC1 MMP9 PMC4598091__F1 Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype HOPX SYK DAP PTEN PMC2743241__F1 Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents DYRK2 REN SUFU GSK3B SMO GLI3 PMC5751802__F3 Signaling pathways corresponding to Tables  and CDC20 ATM MDM2 PMC8639975__F4 Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training ACHE TNC CAMK2G PMC8990433__F1 Cholesterol metabolism and its implication in glioblastoma therapy FAS HMGCR EGFR LDLR YTHDF2 CYP46A1 SRC ABCA1 PMC4058364__F7 HRG-mediated signaling via mTORC2 to mTORC1 ERBB3 RHEB TSC2 ERBB4 HRG ERBB2 PMC7859793__F5 Protein-protein interaction (PPI) analysis of differentially expressed alternative splicing (DEAS) events SSBP3 ARHGAP22 SVIL TMEM237 NEK2 EXOC1 CTNND1 PIK3R1 TANK CLSPN NUMB COX14 RUNX2 KIF23 PIDD1 GNAS MYLK RARA SLMAP CAMKK2 ARHGEF11 SMARCC2 INSR PPFIBP1 CENPK APP F8 NR1H3 LEPR SPTBN1 EZH2 RPL21 NTM ARHGAP19 TROAP VCAN PICALM ACAN CD44 RPL3 NCOR2 PTPRS SYNC ZNF2 ARHGEF4 MAPK7 CHEK1 Meflin PMC8660802__F2 Biogenesis and release of exosomes CD81 HLA-G CD9 TSG101 CD63 PMC4199550__F3 Iron Necessity: The Secret of Wolbachia's Success? CPO UROD UROS PMC5727308__F1 WNT signalling pathways ROR1 APC ROR2 GSK3B ARHA RAC1 DAAM1 CTNNB1 PMC7579760__F3 Hepatitis C virus life cycle CD81 EGFR LDLR RHO CLDN1 PMC8670090__F1 Therapeutic Targeting of Autophagy in Pancreatic Ductal Adenocarcinoma ATG101 ATG10 ATG3 ATG12 ULK1 ATG14 BCL2 ATG5 PMC9019160__F1 Targeting the PI3K/AKT/mTOR pathway in epithelial ovarian cancer, therapeutic treatment options for platinum-resistant ovarian cancer RHEB CASP9 TSC2 ATR BAD TSC1 GSK3B ATM PTEN MDM2 PDK2 PMC5138061__F1 Schematic representation of hypothesized cholesterol/phospholipid recycling mechanisms in the injured CNS VLDLR APOE LDLR ABCA1 PMC8712284__F4 Modular control of multiple pathways of Corynebacterium glutamicum for 5-aminolevulinic acid production GAL ARC PMC5662062__F4 Replication Stress Response in Mammals and Trypanosomatids HUS1 TOPBP1 ATR ATRIP RAD1 PMC6325765__F6 Central carbon and Gamma-PGA production pathways RPE PIG59 MAL CS CIT PMC8395475__F2 Adipose Tissue Dendritic Cells: Critical Regulators of Obesity-Induced Inflammation and Insulin Resistance IFNG MMP12 IL13 IL6 PMC12109257__F6 MicroRNAs in oral cancer progression RAN DGCR8 AGO2 EGFR MYC DROSHA PMC6013441__F4 STRING pathway analysis of up- and downregulated genes in MDA-MB-231 cells co-cultured with adipocytes CLDN7 RASD1 EGR1 CSF2 KYNU HEL136 CST1 PSG6 CXCL2 PTGS2 IL6 ID3 LTB IL24 MGP GDF15 STC1 TNFSF10 PMC10489936__F4 Polysaccharides modulate liver bile acids (BAs)-related signaling pathways of metabolic associated fatty liver disease (MAFLD) FGF8A FAS FGFR4 PMC7255470__F7 Schematic representation shows the potential mechanism of Sevo-mediated anti-proliferation and anti-invasion roles in hepatocellular carcinoma cells GSK3B PTEN CTNNB1 PMC7487481__F5 Metabolites, major metabolic pathways and pathway-related enzyme changes in palm oil-grown AMD1 CIT PMC7612806__F1 Simplified schematic of the KYN pathway IDO1 KYNU KMO PMC8358664__F2 P53 Family: A Role in Lipid and Iron Metabolism ACLY MLYCD FAS FASN PMC7745315__F6 Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease NLRP3 IL16 PMC12084451__F7 The differentiation paths of gastric epithelial cells and signaling regulation ATP4B EGF MUC5AC MUC6 CHGB ZBTB7B XBP1 NR3B3 PMC4786305__F2 The Herpes Simplex Virus Neurovirulence Factor G34.5: Revealing Virus–Host Interactions STAT1 STAT2 IRF9 EIF2A JAK1 PMC5500819__F1 Schematic depiction of the strategy employed for mining the O-Man glycoproteome in cell lines with knock-out of COSMC, POMGNT1, POMT1, and POMT2 MGAT5 POMT2 POMT1 POMGNT2 PMC9281180__F2 Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases BAX TAB3 GSDMC GZMA GSDMB IRAK1 DFNA5 TNF TRAF6 IRAK4 GSDMD NLRP3 TLR4 RIPK1 GSDMA PMC9281180__F4 Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases RPE NLRP3 DICER1 HEL-S-62p CD36 IRAK1 NOX4 IRAK4 MYD88 PMC8804176__F2 Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women TLR4 GPER PGRMC1 BDNF PMC9281180__F3 Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases RPE GSDMD NLRP3 TXNIP PTEN METTL3 HEL-S-44 PMC8777261__F4 Proteomic analysis of metabolic pathways supports chloroplast–mitochondria cross‐talk in a Cu‐limited diatom HEL-S-162eP PC TNLG7C PMC11202538__F1 Canonical Shh signalling pathway KIF7 SUFU PTCH1 SOX2 SHH SMO PMC6409697__F9 rLj-112 was internalized with EGFR to suppress the downstream signaling pathways to initiate the anti-tumor steps in B16 cells EGF EGFR MTOR PMC4105535__F4 Molecular Changes in Pre-Metastatic Lymph Nodes of Esophageal Cancer Patients RB1 JUN SP1 BRCA1 DKK1 BMP4 MYC LEF1 PMC4689162__F1 Beclin-1 interaction complexes Atg14L and UVRAG/Bif-1 activate the Beclin-1 complexes and induce the formation of autophagosomes in a mutually exclusive manner HMGB1 MAP3K7IP1 VMP1 UVRAG AMBRA1 TRAF6 PMC11202538__F3 Targeting the Shh signalling pathway regulators SUFU PTCH1 SOX2 SHH SMO PMC11202538__F2 Crosstalk with the Shh signalling pathway RHEB TSC2 TSC1 SUFU APC PTCH1 SOX2 SHH SMO PTEN CTNNB1 PMC8245914__F10 HYD-PEP06 suppresses hepatocellular carcinoma metastasis, epithelial–mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/Beta-catenin signaling activation APC GSK3B LRP5 LRP6 CTNNB1 PMC10372646__F1 Pomegranate-specific natural compounds as onco-preventive and onco-therapeutic compounds: Comparison with conventional drugs acting on the same molecular mechanisms EGF IGF1 GSK3B SHH PTEN PMC9221433__F7 Targeting Acid Ceramidase Inhibits Glioblastoma Cell Migration through Decreased AKT Signaling RPTOR EIF4B STK11 EIF4EBP1 DDIT4 ULK1 HIF1A MTOR RHO RAC1 EIF4E RHEB MLST8 TSC2 RICTOR MAPKAP1 TSC1 INSR PDPK1 FKBP1A PRKCA PC AKT1S1 DGKZ PMC4689162__F3 Autophagy and some of its regulatory pathways Binding of insulin or growth factors to the insulin receptor triggers the PI3K pathway, converting PIP2 into PIP3 that recruits PDK1 and Akt to the plasma membrane RHEB TSC2 TSC1 ATG12 ATG5 IRS1 PMC5136547__F4 Beneficial effects of immunobiotic bifidobacteria on the innate immune response against rotavirus in intestinal epithelial cells (IECs) JUN MAVS STAT2 RNASEL IRF3 TRAF3 CXCL10 TRAF6 FOS RAC1 STAT1 TLR3 JAK1 TYK2 PMC6110855__F1 Phenotype change of microglia in neurodegenerative disorders ARG1 CD163 IL1B SRA1 PMC6892558__F4 East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide GAL TRIO F11 PMC4600211__F2 Pathway Express analysis of the host response to IBV infection in the trachea of susceptible birds (Line 15I) CD40 IL19 CD80 CANX TIRAP CTSK TLR9 CD14 CPO CTSS IRF3 B2M TRAF3 TRAF6 IRAK4 RAC1 MYD88 HEL-S-99n IFNG CD74 TLR4 TAP2 LBP FADD PMC5425374__F2 Hsp70 in signal transduction pathways SMAD2 SMAD4 TRAF6 PMC4946416__F1 PI3K/PKB/mTOR signaling pathway regulates cancer cell metabolism RHEB TSC2 TSC1 FASN TCF4 MDM2 MTOR MYC CTNNB1 PMC8699194__F1 Insight into the Double-Edged Role of Ferroptosis in Disease SLC3A2 CISD1 LOX KEAP1 GPX4 DPP4 HEL-S-89n SLC7A11 PMC2939392__F2 Proposed inhibitory mechanisms of SOCS1 on TLR signaling SOCS1 TIRAP TLR4 MAL IRF3 MYD88 PMC8268847__F3 MRNA Translation by Hormone Receptors in Breast and Prostate Cancer EEF2K CTU2 CTU1 EIF2A ALKBH8 ELF3 PMC5429724__F4 Intracellular levels of interleukins are related to circulating UCB and underlying molecular measures of heme catabolism CRP PMC5429724__F3 Graphical summary of inter-variable connections for the entire BiliHealth study population CRP IL1B PMC9531511__F2 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis ULK1 ATG5 PMC9531511__F1 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis TBK1 CGAS IRF3 PMC9531511__F4 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis TBK1 CGAS GPX4 POLI IRF3 PMC9531511__F3 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis RIPK3 CGAS MLKL IFNAR1 RIPK1 TNF PMC11562918__F3 HSV-1 mediates innate immune signalling and escape strategies TBK1 CGAS MAVS TLR9 IRF3 IFI16 TRAF3 TRAF6 MYD88 NLRC4 CBL NLRP3 TLR3 DDX41 PMC11756206__F4 Signaling pathways regulated by H EGFR APC TNF CTNNB1 PMC11756206__F3 Aberrant Wnt/Beta-catenin, STAT3, and Hippo/YAP signaling pathways activation in H LATS1 STAT3 EGFR IL2 RHO SRC TNF CTNNB1 PMC9531511__F5 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis CGAS GSDMD AIM2 IL1B PMC10297881__F13 Apoptosis and p53 signaling pathway in all analyzed groups BCL2A1 CTSH PIK3CD PIK3R1 CTSS CTSC TNFRSF10A GTSE1 CDKN2A NGF BIRC5 CDK6 TUBA4A CCND2 GADD45B BIRC3 CDC2 THBS1 SIAH1 RRM2 CTSL TNF BCL2L11 FOS DDB2 IGF1 CTSO IKBKB SESN3 DDIT3 BCL2 MAPK10 SESN1 SESN2 TNFSF10 GADD45A PMC11756206__F2 Development of gastric cancer is induced by H STAT3 TNF TEAD4 CTNNB1 PMC10297881__F12 Apoptosis and p53 signaling pathway in the control compared to adipocytes, chondrocytes, neural-like cells and osteoblasts BCL2A1 PIK3R3 PIK3CD PIK3R1 CTSS TUBA1B MAP3K14 TNFRSF10A SPTA1 GTSE1 NGF CDK6 TUBA4A CCNG2 CCNB1 CCND1 BIRC3 CDC2 TUBA1A THBS1 SIAH1 RRM2 CTSK DAB2IP TNF BCL2L11 FOS TUBA1C CCNE2 IGF1 HEL-S-130P CHEK1 SESN2 PS1TP5BP1 PMC9550864__F2 Deregulated hyaluronan metabolism in the tumor microenvironment drives cancer inflammation and tumor-associated immune suppression CD44 HYAL2 PMC4537205__F5 Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway STK11 CAB39 DDIT4 RPS6KB2 RPS6KA1 PTEN HIF1A PPP2CA MTOR PRKAA1 PRKCB PDPK1 AAG1 EIF4A1 RRAGA MAPK1 RPS6 EIF4B EIF4EBP1 EIF3A VEGFA IRS1 RHEB TSC2 EIF4G1 TSC1 IGF1 PMC4386371__F5 Model for the role of specific acyl-CoA oxidase homo- and heterodimers in the biosynthetic pathway of (omega-1)-ascarosides (A) and omega-ascarosides (B) C6 ACOX1 HEL-S-62p C9 ACOX3 PMC6504559__F7 Schema of possible mechanisms of action of MyD88−/− donor T cells during aGVHD IL33 MYD88 PMC2408969__F8 Deciphering the Ubiquitin-Mediated Pathway in Apicomplexan Parasites: A Potential Strategy to Interfere with Parasite Virulence RBX1 UBC CDC20 APC MAL SKP1 PMC9101511__F3 Retinitis Pigmentosa: Progress in Molecular Pathology and Biotherapeutical Strategies GSDMD TRADD TRIL ULK1 TAB3 AGL ULK2 FADD PMC8944605__F3 MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence SIRT7 SIRT4 SIRT5 NAMPT EZH2 HIF1A SIRT2 BMI1 SIRT3 F3 GATA4 SIRT1 SIRT6 PMC6117394__F4 Biochemical mechanisms of oncometabolite accumulation FH ACO2 KEAP1 HEL-S-26 HEL-75 PMC6117394__F3 Mitochondria at the crossroad of metabolic and signaling networks ACLY MTHFD2 FH HEL-S-133P FASN MTOR CS HEL-S-51e MYC KRAS TFAM ACSS2 SIAH2 C2 HEL-S-162eP SHMT1 CPT1C GLS2 PMC5522055__F3 Actinidia chinensis Planch root extract inhibits cholesterol metabolism in hepatocellular carcinoma through upregulation of PCSK9 PCSK9 NR2A1 HMGCR INSR LDLR APOB SREBF2 AMFR MTOR INS HNF1A INSIG1 PMC8101191__F2 Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression CD44 STAT3 RELB SOX2 ADAM10 TCF4 PRKCB PMC9367163__F7 Combination of high glucose and LPS induces autophagy in bovine kidney epithelial cells via the Notch3/mTOR signaling pathway ATG3 MTOR NOTCH3 PMC5706385__F6 Schematic model for ZJW extracts in inhibiting 5-HTR1D and attenuating Wnt/Beta-catenin signaling pathway MMP7 GSK3B AXIN1 LRP5 MMP2 DVL3 DVL2 TCF4 CCND1 LEF1 CTNNB1 PMC7349567__F1 Regulatory metabolic pathways of ferroptosis TF SLC3A2 IPP HMGCR GLS STEAP3 GPX4 FACL4 SLC7A11 PMC6194902__F1 Terpenoids biosynthesis pathway (A), and pathway engineering strategies (B,C) TF C6 IPP HEL-S-62p C2 PMC4405118__F1 A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome SUFU SHH SMO GLI3 PMC6105016__F7 Investigating genetic-and-epigenetic networks, and the cellular mechanisms occurring in Epstein–Barr virus-infected human B lymphocytes via big data mining and genome-wide two-sided NGS data identification RNF41 BAX SRI JUN CHMP5 RNF4 RPS14 CD46 GRN TRAF3 FOS RAC3 RGS17 F2 RELA SLC25A6 RBPMS KANK2 SCO2 GRB2 HEL-S-283 PSAP ATG5 PMC4595346__F3 Connecting Myokines and Metabolism ALK IGF1 GDF11 SMAD2 GSK3B SMAD4 CCND1 PMC11670023__F1 Triggering receptor expressed on myeloid cells signaling pathway ZAP70 SYK HMGB1 TREM1 PGLYRP1 CD177 IRAK1 MMP9 TRAF6 IRAK4 MYD88 TREM2 MAP3K7IP1 NLRP3 GRB2 CARD9 PMC4497387__F1 Radiation-induced acetylated and deacetylated proteins RPS29 TNPO1 RPL12 GNB2 RPS2 RPSA NPM1 RPS12 RPS9 HEL2 PS1TP5BP1 PMC8348158__F8 Transcriptomic and Metabolic Network Analysis of Metabolic Reprogramming and IGF-1 Modulation in SCA3 Transgenic Mice RHEB GP6 IGF1 ZNF183 IGF1R GHR PMC8799879__F1 Symphony of nanomaterials and immunotherapy based on the cancer–immunity cycle HEL-S-92n CD80 FAS PMC7279373__F1 Interplay between reactive oxygen species (ROS) and the central carbon metabolism HEL-S-162eP ME1 PMC6678695__F7 Scheme of autophagic cell death induced by the combination of Oxaliplatin and DHA ATF4 EIF2A SESN2 PMC4805512__F1 TNFR1-driven pathway RIPK3 MLKL RIPK1 TNF PMC6336165__F2 Theory for polymicrogyria and brain arteriovenous malformations in HHT BMP10 DLL4 PTEN VEGFA PMC7395594__F2 Nrf2-ARE and Wnt/Beta-catenin/GSK-3B intertwined signaling cascades KEAP1 APC MAF PMC3096496__F6 Model depicting the generation and consequences of ROS-mediated base damage NEIL2 NEIL1 UNG NTHL1 MBD4 PMC7501057__F7 Intercellular fibrin networks prevent erythrocyte leakage REST PLG VCAM1 PMC3580432__F2 Possible key signaling components in the force-mediated stem cell differentiation LPA VASP HEL-S-62p SUN1 ARHA RUNX2 PMC7985188__F1 Data, methods (a) and results (b) for TBNC network identification (A) Workflow of the proposed computational approach BRCA1 SET PMC9210594__F2 Potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review BMI1 HGF RELA VEGFA RUNX2 CCND1 PAX7 PMC8732357__F2 DDRugging glioblastoma: understanding and targeting the DNA damage response to improve future therapies FANCE ATR ATM FAP SSB PARP1 MGMT PMC11566155__F7 Axon guidance pathway analysis CDC42 CXCL12 RYK ROBO1 NCK2 SLIT1 ROBO2 PER3 FYN SLIT2 RHOD SHH SMO RND1 SEMA7A ROBO3 NCK1 BMP7 HEL-S-28 ARHA gdf7 SEMA3A RAD1 PTCH1 FES CXCR4 PMC3245021__F3 Reformatted modeling of the BioCarta ‘apoptotic signaling in response to DNA damage’ pathway BAX BCL2L1 BAD CYCS BCL2 ATM APAF1 PMC5573916__F3 Simplified mTOR signaling network with interactions inferred from modeling approaches EGF TSC2 TSC1 EGFR IRS1 PMC2919228__F6 Systematic Analysis of Essential Genes Reveals New Regulators of G protein Signaling CDC42 FAR1 RHO PMC5531453__F5 A, Multifactorial etiology of adhesion formation TF PLG HIF1A PMC2981460__F1 TGFB canonical signal transduction pathway and transcriptional responses mediating TGFB growth inhibitory effects SMAD2 SMAD4 PMC7882924__F9 Graphical illustration of the function and mechanism of miR‐144‐3p in combination with hBMSCs CCND1 CDK4 PMC11504891__F2 CSF-1R axis mediates the crosstalk between tumor microenvironment cells IL34 ARG1 IL6 FAP IL8RB PMC9512540__F3 Identification of Key Genes and FUNCTIONAL Pathway in Radioresistance of Non-Small Cell Lung Cancer SLCO4C1 PMAIP1 GBP4 DMRT1 SH3BGRL2 INHBA CYGB CCR1 ANKRD1 TIMP3 PFKFB4 TP53INP1 MPZ ARL14 MMP10 PCDH7 F13B PHTF1 RSAD2 IL1A AKR1C1 CXCL10 KRT6A CXCL11 DEFB1 MPZL3 FGA TCN1 NPPB SDC2 DACT2 ENPP4 CFHR4 FAS GLS TIMP4 F5 HEL-S-62p EBP CD82 IFIH1 CD300C KLHL30 GDA LCE1B SPANXN3 CRISPLD1 SLAMF7 RTN4RL1 ACTRT3 ZC3H12D CRCT1 C2CD4A AFP PPBP KRTAP5-10 CD33 C8orf48 SERTAD4 SAA2 GPR87 ZBED2 RGS22 NAP1L2 SPANXN5 GBP2 MSMB GBP3 ITIH2 ACTBL2 GLIPR1 CARD6 HEL-S-8a CFHR3 SAMD9 TSPAN12 SLC16A2 SESN3 SPINK6 BMP2 RASSF9 KLHL4 HYAL4 PMC4930117__F1 DNA end resection dictates the pathway choice for both DNA repair and checkpoint response DSBs can be repaired by NHEJ or by HR that requires 3′ ssDNA generated by end resection ATR ATRIP RAD51 ATM PMC6413682__F8 Negative regulation between FoxO3a and EPS8 in EGF/PI3K/Akt pathway STAT3 EGFR MTOR PMC5573916__F1 Major mTOR signaling network RHEB EGF TSC2 TSC1 EGFR GSK3B PTEN TNF IRS1 PMC9512540__F6 Identification of Key Genes and FUNCTIONAL Pathway in Radioresistance of Non-Small Cell Lung Cancer CXCL11 STAT1 IFIH1 RSAD2 JAK1 CXCL10 PMC4487197__F2 Ephrin receptor signaling pathway (genes hypomethylated in the schizophrenia patient of Twin Pair 1) CDC42 STAT3 EGF ANGPT1 PXN KALRN APP TSN ARHA GRB2 SRC SDC2 PMC9590378__F1 Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance PINK1 GDNF IL6 BDNF DIABLO PMC8463184__F3 Idebenone-Activating Autophagic Degradation of Alpha-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson's Disease: A Network Pharmacological Approach TF SYK PIK3CA MAPK11 AVPR2 CHRM1 EGFR PIK3CD PPP2CA MAPK9 NPY5R MTOR CCNA2 PSEN1 MAPK8 MAPK14 PSENEN DRD2 ALK PDPK1 F2 CNR2 APP SMO MDM2 ABCB1 HCRTR2 GAL FASN MAPKAPK2 PDE3B CHRM2 FER PRKDC PSEN2 IKBKB NTRK1 CDK2 PMC4613549__F1 Proposed mechanisms of evodiamine signaling in white adipocytes EGFR MTOR IRS1 PMC2824633__F4 Cyclin D3-specific deregulated genes and their functional networks DBF4 CCND3 RAB27A TRIOBP BEX2 IFIT2 ZNF91 GANAB SKP2 CDK6 PLAGL1 ARL6IP5 CDKN1A TFPI CRLF3 BCAT1 RYR1 WBP4 ARMC8 SLC39A6 TIA1 SETD7 PMC8328776__F3 High mobility group box 1 mediates inflammatory response of astrocytes via cyclooxygenase 2/prostaglandin E2 signaling following spinal cord injury CDC2 HMGB1 GAL STAR SHC1 CXCL1 HLX MYD88 CLCF1 COX2 TLR4 CCL7 MMP3 PTGES LYN SELP PMC5715373__F1 Strategies to generate tolDCs for clinical therapeutics CD40 CD80 FAS PMC7299681__F7 Proposed model of WDR41‐mediated cellular processes in TNBC cells GSK3A WDR41 CTNNB1 PMC275444__F7 Beta-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility CDC42 HEL-S-62p PAK1 ARHA RAC1 PMC12106489__F7 Wnt7b promoting renal fibrosis in AAN PORCN APC WNT7B CTNNB1 PMC5488057__F1 Conceptual model of general health factors, salient CHD pathogenetic pathways and CHD hallmarks COX1 IGF1 VCAM1 MPO PMC6781771__F5 AKR1C1-3 are involved in a pathway with 44 unique interactors HEL107 ABCC1 HEL-S-53e PTGR1 MGST1 SLC7A11 HEL-S-25 AKR1B10 ADH5 TXN TFRC SOST ALDH3A1 SRXN1 ABCC2 UGT1A3 UGT1A7 ABCB6 CES1 OSGIN1 GCLM ME1 AKR1C1 ADH7 CREG1 GPX2 FTL UGDH GCLC TP63 AKR1C2 ABCC5 HEL-75 PMC7937672__F1 Cutting the molecular brakes to achieve cardiac regeneration RAPGEF5 LRP5 HEL-S-28 LRP6 HIF1A TEF CTNNB1 PMC9633658__F1 Muscle-specific MicroRNAs in patients with chronic obstructive pulmonary disease and skeletal muscle dysfunction IGF1 MTOR BDNF PMC3480380__F8 Regulation of Epidermal Growth Factor Receptor Signaling and Erlotinib Sensitivity in Head and Neck Cancer Cells by miR-7 EGF BAD TGFA EGFR HEL-S-28 PTEN MTOR TNF RHEB TSC2 TSC1 CDC37 MDM2 GRB2 CCND1 PMC3932922__F1 Cartoon presentation of LRRK2 showing multidomain structure BAG5 LRRK2 PMC5115958__F2 Non-invasive metabolic imaging of brain tumors in the era of precision medicine LAT MYC PMC5115958__F1 Non-invasive metabolic imaging of brain tumors in the era of precision medicine TIGAR MYC PMC4741450__F9 Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway ATR ATM CCNB1 PMC6004600__F2 Innate immune receptors drive dengue virus immune activation and disease TBK1 SYK MAVS CCL3 CCL4 CCL2 TNF IL1B MYD88 PMC164216__F5 TLR signaling pathways LTA MAP3K7IP1 TLR4 TRAF6 MYD88 PMC8011326__F3 Shh pathway regulated by MID1 MID1 BMP4 SHH PAX6 PMC8166678__F7 “Metalloestrogenic” effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid cells FOXM1 HBEGF CDK6 EGFR CCND1 CDK4 PMC4281293__F2 To reveal potential pathways involved in pancreatic cancer survival, the Ingenuity Pathway Analysis (IPA) was used for upstream regulator analysis SLC25A5 MFAP4 CBFB HEBP1 S100A6 PPP2CA PCBP1 HEL-S-25 MDH2 VEGFA SET PMC9178660__F2 Advances in Immunosuppressive Agents Based on Signal Pathway LTBR TRADD COX2 RELB TRAF5 IRAK1 TRAF3 TRAF6 TNF TRAF2 IRAK4 MYD88 PMC9178660__F4 Advances in Immunosuppressive Agents Based on Signal Pathway KEAP1 GSC PPL PMC11461658__F3 Tryptophan-kynurenine metabolic pathway HEL-S-90n KYNU KMO HAAO PMC9178660__F3 Advances in Immunosuppressive Agents Based on Signal Pathway RHEB EGF TSC2 TSC1 INPP4B EGFR PTEN IGF1R PDK2 MTOR IRS1 PMC8607389__F5 G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloidB in Alzheimer’s disease LPA BACE1 GSK3B PC ARHA RHO PMC8607389__F2 G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloidB in Alzheimer’s disease CDC42 TREM2 SYK VAV3 SOS1 LAT VAV2 APOE PTEN DOK3 GRB2 MTOR PMC4931191__F2 Relationships between longevity genes affected by the diabetic milieu MTOR SIRT1 PMC8607389__F1 G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloidB in Alzheimer’s disease CASP9 BAD ROCK2 BCL2 PTEN ARHA MDM2 MTOR CCND1 PMC6712508__F6 The proposed mechanism of TN-C release following RV infection of bronchial epithelial cells TLR3 LDLR TLR7 PMC8289367__F3 Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer VIT YTHDF1 PMC8616136__F1 Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy WNT10B WNT3A DKK1 APC GSK3B LRP5 LRP6 CTNNB1 PMC2860348__F1 p38 MAPK mediates the transcriptional response to stress FOXD1 LHX5 ATF2 TGIF1 MYC RUNX2 SOX9 ID4 FOXC1 GATA6 HOXC12 NFKBIZ JUN EGR1 ID2 SOX2 IRF1 NFATC1 FOS PAX1 ID1 FOXG1 ATF3 MAFF DDIT3 FOXA2 EGR2 PMC8616136__F3 Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy DKK1 APC GSK3B LRP5 LRP6 CTNNB1 PMC8616136__F6 Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy DKK1 APC GSK3B LRP5 LRP6 CTNNB1 PMC5291375__F7 Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets SYK EIF4B BAD RAF1 RBL2 PTEN CD19 MTOR RAC1 RHEB GFAP TSC1 BCR PI3 NPB HEL-S-11 MDM2 PMC8049318__F1 MiRNAs and coding genes involved in the milk fat synthesis pathway LPL OXCT1 HMFN0839 DGAT1 BDH1 CD36 SCD FASN ACACA ACSS1 ACSS2 ACSL1 HEL-S-5 LPIN1 PMC4915567__F1 Melatonin pathway and melatonin candidate genes MTNR1A AANAT MTNR1B ASMT ADRB1 PMC6437685__F2 HEV infection leads to the expression of IFN and other proinflammatory cytokines through activation of interferon regulatory factor 3 (IRF3) and nuclear factor kB (NFkB) pathways TBK1 STAT1 STAT2 IRF9 IRF3 PMC5291375__F3 Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets BAD MAL PTEN FHIT PMC8482137__F5A Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups CD40 STAT3 IL10 JUN IFNA13 TGFB1 PIK3R1 CCR3 IL6 GFI1 TBX21 TGFBR1 TGFBR2 IFNAR1 JAK1 IFNA1 PMC12163381__F4 ILs with dual functions STAT3 STAT1 JAK3 IL33 JAK1 PMC10937442__F8 Off-label use of Baricitinib improves moderate and severe atopic dermatitis in China through inhibiting MAPK and PI3K/Akt/mTOR pathway via targeting JAK-STAT signaling of CD4+ cells IL13 IL4 IL5 PMC12163381__F3 ILs mitigating AKI progression STAT3 STAT1 IL2RB JAK3 IL17RB STAT4 JAK1 TYK2 IL13RA2 PMC12163381__F2 ILs exacerbating AKI progression STAT3 STAT1 STAT4 JAK1 TYK2 PMC3826519__F7 Deregulated genes upon miR-196a overexpression in keratinocytes TP73 FAS NFATC4 RBL2 CD40LG TNF CCL2 SMPD2 HSPB3 RB1 NCAM1 E2F4 HOXA9 E2F3 SYNM CDKN1B CDK2 APP PMC2737093__F6 Schematic view of PPARG activation in VSMCs EGR1 MMP24 SMAD2 PMC10571713__F1 Lipid sources include the de novo fatty acid synthesis pathway and exogenous lipid uptake ACLY FAS FASN PMC7508399__F5 Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies CD80 RXRA CS MEF2D PMC8316833__F3 SUMO and SUMOylation Pathway at the Forefront of Host Immune Response KLF4 STAT3 STAT1 TRIM5 JUNB IRF2 IRF1 IRF3 IRF7 IRF4 IRF8 PMC3154612__F1 Simplified diagram illustrating the mTOR signaling pathway EIF4B MTOR EIF4E PMC6660835__F1 Endogenous Nucleic Acid Recognition by RIG-I-Like Receptors and cGAS TBK1 MAVS MRPL18 PMC10382489__F3 PTMs involve some mechanisms in CVDs TXNIP MFN1 MFN2 PTMS PMC8289367__F2 Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer CD40 CD80 TIRAP HEL-S-133P CCR7 YTHDF1 METTL3 PMC2950652__F2 Pioneer Round of Translation: Features and Functions CTIF EIF4B ELF2 PABPC1 ELF3 MAGOH PMC4657151__F1 Skeletal muscle as an endocrine organ: PGC-1A, myokines and exercise SIRT3 MTOR SIRT1 PMC6961892__F7 Liganded T3 receptor B2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production GATA2 TSHB TRH SF1 CGA PITX1 MSX1 PMC3429058__F1 HDL promotes regression CCL19 CD36 CCR7 ABCA1 PMC11411607__F3 Canonical and non-canonical NFKB signaling pathways by andrographolide BCR RELA RELB TNF PMC4299486__F2 Endocrine system development and function BNC1 BDKRB1 KRT14 MYRIP GPR119 TRPC5 GPR55 ANGPTL1 PROKR1 ANGPTL4 GPRC5C CLEC4A SUCNR1 PMC4299486__F1 Cell signaling GPR162 TGFB1 RSF1 TNF SPSB4 GPR157 FOS SST GPR171 ORMDL3 GPR174 RNF20 APP CCNK GPR152 HEL2 BRCC3 PMC7918665__F2 Major groups of micro RNAs (miRNAs) and their related pathways by which they act on endothelial cells ALB BAX PTEN GRB2 MTOR PMC9178660__F6 Advances in Immunosuppressive Agents Based on Signal Pathway CDC42 JUND FAS TRADD PAK1 TRAF2 PMC9178660__F5 Advances in Immunosuppressive Agents Based on Signal Pathway EGF GRB2 PMC2820658__F1 Induction of IFNs after virus infection in IFNB pretreated human DCs IRF7 JAK1 TYK2 PMC7850581__F1 Interferon-stimulated GTPases in autoimmune and inflammatory diseases: promising role for the guanylate-binding protein (GBP) family STAT2 IRF9 APC LRP5 LRP6 GBP1 CTNNB1 GBP5 STAT1 RELA JAK1 TYK2 GBP2 PMC6321285__F1 HGF/c-MET signaling STAT3 HGF PAK1 GRB2 MTOR SRC RAC1 PMC7980187__F9 Possible signaling pathways utilized by SARS-CoV-2 for cellular hijacking PI3 ITK IRF3 RHO GRB2 SRC ACE2 RAC1 LCK PMC1083688__F2 Curbing the nuclear activities of Beta-catenin POLI NLK TBP POP1 PMC8318926__F1 Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy NONO CXCL1 ARHA PMC6349702__F2 Protein-Protein interaction network of the 214 identified proteins: network nodes represent proteins, network edges indicate the strength of data support (STRING v10.5) NAPA HEL-S-22 EHD3 HPSE RAN PPIB HEL-S-21 MGLL PLEK PNP RALB NME2 PPBP YWHAQ TPM3 CNN2 MAPRE2 HEL-S-108 MDH2 SRC HBB DKFZp761E1322 DCD LIMS1 THBS1 POLM STK24 ARHA STOM HEL-S-69p CAPZB CLC RAB13 DKFZp686P11128 SELP PF4 PMC7198573__F3 Map of the T-cell receptor signalling KEGG pathway for Mus musculus, with the colour of nodes representing the level of individual variability in response to stimulation with anti-CD3 and anti-CD28 antibodies in Microtus agrestis GRAP2 CD3D ZAP70 MAPK11 RAF1 LAT CARD11 GSK3B PPP3CA MAP3K14 IKBKG MAP3K8 SOST FYN PDPK1 CHUK CDK4 MAPK1 NCK1 CST2 CD40LG ARHA TNF FOS HRAS ICOS PAK1 NFKB1 IKBKB MAP3K7 GRB2 CD3G CD3E PMC5695813__F5 Mass spectrometry-based quantification of the cellular response to ultraviolet radiation in HeLa cells MSH6 RFC1 MPG CETN2 CDK7 ERCC5 UNG RFC3 PARP2 POLE RPA1 XPC PMC5457443__F6 Functional analysis of IRF5 pathway TMPRSS2 ASB11 CDK17 CNGA1 HCGV ENPP7 TACR3 DHX58 GRID2 RNF26 UBE2T HUWE1 MMP11 GPR85 RIPK2 GPR132 MMP24 GPS1 FBXO34 KCNN2 MAP2K2 PFKM MRGPRG PMC8905437__F1 Key Enzymes in Fatty Acid Synthesis Pathway for Bioactive Lipids Biosynthesis CIRSR GLA TNLG7C PMC9426616__F2 Human immune polymorphisms associated with the risk of cryptococcal disease SYK TBK1 RAF1 TLR9 IRAK1 TLR5 IRF3 TRAF3 TRAF6 IRAK4 MYD88 TLR1 BCL10 TLR3 TLR4 TLR8 TLR7 TLR10 CARD9 PMC3906588__F1 UPR response underling memory consolidation in Alzheimer's disease APP ATF4 EIF2A XBP1 PMC6879357__F6 Long non-coding RNA TCONS_00000200 as a non-invasive biomarker in patients with intracranial aneurysm PTPRM CD226 CD40 ICOSLG TH CD80 NRCAM SELPLG CD22 PTPRC NTNG2 ITGAV CD99 JAM2 ITGA6 CNTN2 CDH4 CD6 CDH2 ICAM2 CD2 ESAM MPZ ITGA4 SELL ITGB7 SELE APC CLDN2 CD34 SPN ICOS TIGIT ITGAM SELP PMC4506163__F4 Gene product association networks extracted from the most significant (A) cellular and regulatory process pathways and (B) metabolic pathways involved in arteriotomy-induced carotid stenosis (listed in Table ) ENO1 EAPP ASPA PMC7316184__F1 Trimethylamine N-oxide (TMAO) metaorganismal pathway NLRP3 FOXO1 ABCG2 PMC12245910__F2 The TSCC in the mTORC1 signaling pathway RHEB CDC2 MLST8 TSC2 TSC1 TBC1D7 MTOR DEPTOR PMC3836826__F3 Stress-response pathways are altered in the hippocampus of chronic alcoholics TXNIP TLR4 IL6 IL1B PMC7883599__F4 SIRT1 and SIRT2 in Huntington’s disease UCP1 SIRT2 BDNF SIRT1 PMC9152417__F8 Extracellular Vesicles Carrying miR-887-3p Promote Breast Cancer Cell Drug Resistance by Targeting BTBD7 and Activating the Notch1/Hes1 Signaling Pathway BTBD7 HES1 NOTCH1 PMC7736111__F2 Molecular and signaling pathway implicated in host cell antiviral response TBK1 MAVS TRADD TRIM25 TRAF5 IRF3 IRF7 TRAF3 TRAF6 ACE2 TRAF2 PMC10476815__F6 Predicted targets of Ruxian Shuhou prescription in the PI3-Akt signaling pathway SYK CASP9 BAD GAL RBL2 PTEN CD19 MTOR MYC RHEB TSC2 BCR CD37 RXRA MDM2 GRB2 PMC4400874__F3 Initiation and perpetuation of NLRP3 inflammasome activation and assembly CASR TRPM2 GPRC6A NLRP3 TRPV2 PMC3285438__F5 Simplified signaling pathway of the effects of resveratrol involved in metabolic control in the skeletal muscle RBP4 SIRT1 IRS1 PMC6089393__F9 PM2.5 induced cardiac hypertrophy via CREB/GSK3b/SOS1 pathway and metabolomics alterations GATA2 KLF2 CACNA1C ETS2 SP1 NMT1 HIF1A VEGFA MEF2C MYOG NOSIP ZDHHC21 NR3A2 AKAP6 PDE3A SP3 EDNRB GATA4 CREB1 BDKRB2 NMT2 PMC10458348__F4 Histone Modification of Colorectal Cancer by Natural Products CD44 APC GSK3B LRP6 MYC CTNNB1 PMC3269610__F2 BMP signaling and negative regulation in bone formation SOST DKK1 MSC RUNX2 PMC5743847__F1 Lipoquality control by phospholipase A2 enzymes LTB LTA COX1 PMC3309723__F5 Parp1 mediation of Sox2 activity in ESC pluripotency STAT3 PARG LIF SOX2 PARP1 PMC11531143__F4 PIM1-mediated signaling pathways in lung cancer BAX PIM1 HEL-S-133P HK2 TAB3 GRB2 MTOR PMC11531143__F3 PIM1 signaling in Hepatocellular carcinoma BAD PIM1 EGFR IL6R PMC11531143__F5 PIM1 activates AKT signaling in ovarian cancer EGF BAD CDK6 GDNF PIM1 HEL-S-68p EGFR MTOR VILL CCND1 PMC9659297__F4 Biological Relevance of Papaverine in Cancer Cells EGF RICTOR PTEN RHO MTOR PMC8157467__F7 3-Methyladenine but not antioxidants to overcome BACH2-mediated bortezomib resistance in mantle cell lymphoma HMOX1 BACH1 BACH2 PMC6053318__F2 Everolimus and Sirolimus in Transplantation-Related but Different RHEB RPS6 TSC2 BAD TSC1 EVL PTEN MDM2 IRS1 EIF4E PMC3880796__F2 TRAIL on Trial: Preclinical advances for cancer therapy BAX CASP9 CASP3 APAF1 DIABLO FADD PMC4576979__F4 Harnessing the apoptotic programs in cancer stem-like cells HEL-S-133P FOXO3A HEL-S-30 PMC11531143__F2 PIM1 enhances aggressive oncogenic characteristics in breast cancer through multiple mechanisms CAPZA1 BAD TRIM28 PIM1 CDKN1A NFATC1 CDKN2B NOTCH3 HNRNPK IL6R NOTCH1 RUNX3 PMC4823938__F1 Schematic overview of necroptotic pathway STAT3 TRADD TLR3 MLKL TLR4 IRF9 IRF1 IRF3 IRF7 CYLD FADD PMC11531143__F1 PIM kinase family gene structures PIM2 PIM1 HOXA9 PIM3 SOCS2 HIF1A PMC9627168__F2 Lactate drives cellular DNA repair capacity: Role of lactate and related short-chain fatty acids in cervical cancer chemoresistance and viral infection FFAR3 LDHD FFAR2 PMC3107442__F5 Transcripts (p < 0.05) involved in cell signaling GRM4 GAD1 GAD2 GRM2 PMC8210623__F4 Analyzing signaling activity and function in hematopoietic cells TLR4 IRF3 TNF MYD88 PMC9283712__F1 TNFA Inhibitors and Other Biologic Agents for the Treatment of Immune Checkpoint Inhibitor-Induced Myocarditis TRADD TRAF2 FADD PMC5417301__F11 Model summarizing the regulation of GR by TTC5 JMY MDM2 PMC7761238__F1 Interaction of interleukin-2 (IL-2) and IL-15 with their receptors and downstream signaling pathways STAT3 JAK3 IL2RA MTOR JAK1 IL15RA PMC4587761__F3 Network associated with the proteins in TNFAIP6 VLDLR PLG CD14 GHRL C4A TFPI APOH MSR1 CPN2 APOB GPLD1 C4B_2 PMC7359176__F3 Unphosphorylated glycogen synthase kinase-3B (GSK-3B) and canonical WNT/Beta-catenin signaling in “off” state APC GSK3B LRP5 LRP6 CTNNB1 PMC7359176__F2 Phosphorylated glycogen synthase kinase-3B (pGSK-3B) and canonical WNT/Beta-catenin signaling in “on” state APC LRP5 LRP6 CTNNB1 PMC6795080__F1 Mevalonate pathway intermediates active in feedback control CYP51A1 MSMO1 DHCR24 FDFT1 HSD17B7 TM7SF2 LBR PMC2773299__F2 Schematic representations of the activated RAS-MAPK, RASSF1A/NORE1A, and Dab2IP/ASK1 pathways, iNOS signalling, and FOXM1-related pathways involved in the dysregulation of cell growth and apoptosis in HCC AURKA FOXM1 RAF1 NEK2 DAB2IP EPO CDC37 VEGFA SKP2 CDC25B PMC5010756__F4 Sensing of HMPV by different PRRs and modulation of the IFN response by viral proteins MAVS TLR3 TLR4 IRF3 IRF7 TLR7 JAK1 TYK2 MYD88 PMC4600616__F1 Sonic Hedgehog in SCLC GRPR SHH SMO RHO PMC4904844__F5 Interaction network of 135 SNO-modified proteins identified in WT and AD mouse brain tissues IDH3B CLTA ZNF183 HEL-S-32 NDUFA2 ENO1 CS ARHA MDH2 RAC3 PMC6281417__F7 Human liver stem cell-derived extracellular vesicles enhance cancer stem cell sensitivity to tyrosine kinase inhibitors through Akt/mTOR/PTEN combined modulation PTEN MTOR PMC8781199__F2 Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders TCP1 CRMP1 CCT6A HEL-S-133P GSK3B CCT4 HIF1A LDHB HEL-S-94n HEL-S-100n PABPC1 HEL-S-69 CCT7 TSC1 CCT8 HSPA4 PMC9527825__F1 Possible mechanisms for ANGPTL1 attenuating CRC liver metastasis SOX2 TWIST2 MMP9 PMC5742686__F3 The NLRP3 inflammasome in ORKD development NLRP3 TXNIP TLR4 IL1B PMC5535903__F2 Nucleolar response to DNA damage BAX RAD51 BRCA1 WRN FBL NPM1 ATM BLM NCL PMC3260814__F1 Personalizing Therapy with Targeted Agents in Non-Small Cell Lung Cancer EGFR PTEN MTOR PMC3915522__F5 Ras oncogenes: split personalities CDC42 RINL RIN1 RHO RALBP1 PMC7927090__F2 Summary of key pathways regulated by H2S donors in the treatment of CVDs STAT3 SGK1 HEL-S-11 ATF4 MTOR TRAF6 TRAF2 SIRT1 PMC2840045__F1 Innate immune responses in allotransplantation HMGB1 TLR4 PMC9557197__F1 Ferroptosis in glioma treatment: Current situation, prospects and drug applications SLC3A2 LOX STEAP3 GPX4 FACL4 HEL-S-64p PMC6861914__F7 Apoptosis pathway in LNCaP cells treated with LEP (1 × 10−6 M) BAD CASP6 CAD CASP2 HAT1 HEL-S-11 TEP1 ME1 HRK TRAF2 FADD PMC6861914__F6 p53 signaling pathway in LNCaP cells treated with LEP (1 × 10−6 M) RFWD2 CASP9 ATR CD2 SIAH1 AIFM2 PERP PTEN MYC TSC2 CASP3 CDK2 ATM MDM2 APAF1 CDK4 PMC11278074__F1 Therapeutic approaches to vascular Ehlers–Danlos syndrome ATR MMP9 SRC PMC4502774__F1 Schematic stages of the autophagic pathway SH3GLB1 ULK1 UVRAG ATG14 MTOR STX17 ATG101 ATG10 ATG3 ATG12 PI3 AMBRA1 BCL2 ATG5 ULK2 PMC3480285__F5 A Systems Biology View of Responses to Lignin Biosynthesis Perturbations in Arabidopsis LAT CCR3 ACD CS CCR1 PMC3480285__F1 Metabolic Map of Phenolic Metabolism in the Inflorescence Stem of Arabidopsis.The main pathways involved in lignin biosynthesis are framed with a bold black border CS SST PMC4590996__F2 Biomarkers of primary open-angle glaucoma CD44 TBK1 TLR4 CD14 IRF3 TRAF6 LBP MYD88 PMC8662602__F1 Evolutionary Profile for (Host and Viral) MLKL Indicates Its Activities as a Battlefront for Extensive Counteradaptation RIPK3 ZBP1 MLKL RIPK1 PMC4254928__F3 Insights into Molecular Features of Venerupis decussata Oocytes: A Microarray-Based Study FZD8 APC DVL3 LRP6 WNT4 CTNNB1 PMC7367617__F3 KEGG enrichment of 249 DEGs identified between chemotherapy sensitive and insensitive OC HBEGF JUN LTA GADD45G CXCL2 SOCS3 TNF FOS CXCL3 PMC8509036__F1 B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer Therapy BAX BAD TRADD TNF TRAF2 FADD PMC4202122__F2 Altered Mucins (MUC) Trafficking in Benign and Malignant Conditions RAB31 EGFR MUC1 GRB2 NUP62 CTNNB1 PMC7106881__F9 Hypothetical action mechanism of aspirin on nonalcoholic fatty liver and atherosclerosis FAS HMGCR CCR2 PMC4586018__F6 Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2 ADRBK1 TG PMC6520588__F3 Schematic drawing showing proposed mechanisms of action of Curcuma longa (curcumin) BAX GRAP APP PMC6805653__F10 Molecular mechanism of miR-129-5p regulation of ZIC2 expression and the Wnt/Beta-catenin signaling pathway in PCa CDH2 ZIC2 CTNNB1 PMC3760627__F2 Diving adaptations in the Chinese alligator genome GGPS1 PTDSS2 ENPP3 NDUFB5 CTPS2 ACSL5 SMS PTDSS1 ACADS GGT7 HBA2 NDUFB10 GNS C2 SRM GLB1 HBB PMC4248697__F2 Synthesis of isoprenoid products in P IPP PMC7559774__F3 tRF-Leu-CAG, ts-101, ts-46, and ts-47 are involved in drug resistance of lung cancer cells AURKA RALB GSK3B HEL-S-28 PTEN MTOR SRC KRAS CCND1 PMC3092098__F1 The genes and pathways associated with Crohn's disease pathogenesis ICOS ICOSLG TAGAP TGFA ICAM3 IRGM IL2RA REL CCL20 MUC19 CARD9 PMC8980325__F1 Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity ACLY FAS COX1 HMGCR COX2 SCD HEL-S-11 ARHA PMC7395594__F6 Nrf2/Wnt/immune crosstalk in oxidative stress and inflammation in PD KEAP1 COX2 APC TNF PMC9688663__F1 Advances in Understanding of Metabolism of B-Cell Lymphoma: Implications for Therapy SYK BTK OGDH PHGDH DHFR SHMT1 TYMS SRC MYC HEL-S-51e PMC6261607__F8 Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors CSA2 SMAD2 ARHA PMC6250427__F4 Mitogen activated protein kinase (MAPK) signaling pathway TF MAX MYC PMC5109738__F5 Proposed novel caspase-1 working models NLRP3 OCEL1 PMC7335630__F2 Immunological response of SARS-CoV-2 TMPRSS2 TNF ACE2 CD47 PMC4716095__F1 mTOR signaling RHEB TSC2 TSC1 SGK1 PMC6529242__F5 Mechanisms induced by MC-GAG on osteoprogenitors and osteoclast progenitors SMAD1 DKFZp781O1323 SMAD4 PMC8841737__F2 Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor LATS1 PTPN18 STAT3 BAX LATS2 ATG2B KIT PTEN IGF1R MDM2 MTOR PMC7856198__F5 Gene identification and pathway Network Analyses of the IL-4R responsive transcripts in the metabolic MMC9 cluster MTHFD2 TUBA1A TH MRPS5 PYCARD KGD4 DKC1 MICA TYMS GALK2 MRPS12 ANKRD26 CDA TMEM85 USP22 MCM6 PMC4403665__F1 Chemotherapeutic Targeting of the Transforming Growth FactorB Pathway in Breast Cancers SMAD2 SMAD4 MTOR SRC PMC2242712__F1 Phenolic lipid synthesis in A C2 PMC8165235__F1 Perspective: Humanized Pig Models of Bladder Cancer HRAS PIK3CA FGFR3 PTEN PMC3269833__F6 Potential regulatory mechanism of the identified gene switches for breast cancer RASD1 BEX2 ERBB2 CCND1 TACSTD2 PMC7501082__F2 Involvement of host and viral proteases in SARS-CoV-2 life cycle TMPRSS2 FURIN ACE2 PMC8493693__F4 Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis COX7B HEL-S-123m ND4L COX7A1 COX1 COX10 COX7C CYC1 ATP6 ATP5MG COX17 ATP5PO COX8A UQCRB COX2 ND6 COX3 ND3 ND2 ATP5G1 ND1 ATP5MF ATP5PB ND4 COX5A SDHD SDHA SDHB CYB ND5 UQCRFS1 ZNF183 COX11 SDHC PMC8913874__F5 How water‐soluble saccharides drive the metabolism of lactic acid bacteria during fermentation of brewers' spent grain FOS PMC10311176__F3 Transcriptome analysis of CD4+ T cells from HIV-infected individuals receiving ART with LLV revealed novel transcription factors regulating HIV-1 promoter activity CD40 SYK MYBL2 TNLG7A NR4A3 TCF4 CXCL8 NFIL3 MAP3K8 NFE2 CTBP2 PLCG2 PAX5 OASL TRIB1 ZEB2 IGF2BP2 SOX4 CSRNP1 TFEC FOSB HHEX JUNB IRF8 TNF FOS ATF3 CUX2 CEBPA HOXA9 CCL4 EGR2 KLF4 MMP14 TNFAIP3 SETBP1 CREB5 CREM TBX21 TNFRSF13C TLR4 CEBPD MSC KLF10 SOX5 IL1B JUN EGR1 PER1 LIF MAFB CXCL2 MMP9 IRF4 PTGS2 IL6 BCL11A HOXC4 VENTX NFKBIA BCL6 PMC10911341__F9 Potential mechanisms of inhibiting Perk-ATF4-P21 pathway to enhance the efficacy of MPPAlpha-PDT ATF4 EIF2A ATG5 PMC11589783__F5 KEGG graphical of MAPK signaling pathway32 MAX EGF JUND FAS TRADD CD14 KIN TRAF6 REL TNF CDC25B PMC3296202__F1 Pathways involved in diabetes-induced EPCs toxicity and possible strategies to reverse EPCs damage during bone marrow mobilization ROS1 GLO1 MMP9 CXCR4 PMC11589783__F6 KEGG graphical of FoxO signaling pathway32 STAT3 EGF LAT EGFR SMAD4 PTEN PDK2 INS SKP2 FOXG1 INSR CDK2 NLK MDM2 GRB2 PMC9502082__F1 RIOK3 and Its Alternatively Spliced Isoform Have Disparate Roles in the Innate Immune Response to Rift Valley Fever Virus (MP12) Infection TBK1 MAVS IRF3 PMC2923990__F7 Model for C SYK BCL10 TLR4 CARD9 MYD88 PMC2889938__F2 Target gene regulatory network, NFKB/RelA:P50 IL15 CXCL9 FAS TIMP1 TGFB1 CCL3 CXCL5 CD69 CXCL1 RELB IL2RA TAP1 YY1 SOCS3 MYC IL15RA PTPN13 BCL2L1 F3 IL1B BIRC3 HLA-DMB SLC11A2 IL10 CSF2 CCL11 JUNB IRF1 CXCL2 IRF7 GBP1 MMP9 IL6 TNF LTB CCL19 NFKB1 RELA NFKBIA BCL2 STAT4 VCAM1 SELP IL23A PMC5645611__F1 One marker is not enough for designate one cell as cancer stem cell CD44 EPCAM CD24 CTNNB1 PMC11637887__F3 Comparison of changes in the eye among normal, non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR), and the signaling pathways of DNA methylation alterations associated with DR development TET2 NR1C1 TIMP1 RAC1 PMC11637887__F6 Impact of DNA Methylation on Schizophrenia CRH GAD1 CNR1 NR3C1 PMC4102070__F4 Points of inhibition for ibrutinib, idelalisib, fostamatinib, and Lck-i in the BCR signaling pathway BTK PLCG2 BLNK LYN LCK PMC11637887__F7 DNA methylation changes in the pathogenesis of HD and the cellular impact of toxic huntingtin protein variants APEX1 BRCA1 RPA3 SOX2 HEL70 BDNF RPA1 PMC6351542__F5 S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy RYR3 FZD10 RYR1 ITPR2 ITPKC PMC4102070__F2 Signal integration following BCR engagement BTK PLCG2 RASGRP3 BLNK LYN GRB2 PMC9509681__F7 Relevance of Host Gut Microbiome Signature Alterations on de novo Fatty Acids Synthesis in Patients with Multi-Drug Resistant Tuberculosis ACLY FAS SLC25A1 PMC8964949__F6 Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness STAT3 EGF ADAM8 MMP9 SPP1 PMC8774282__F2 Breakthrough Brought about by Targeting KRASG12C: Nonconformity Is Punished ALK FGFR3 MTOR KRAS RET OTP PMC3610285__F2 Melanogenesis MAPK1 EDN1 GSK3B EDNRB DCT TYRP1 EP300 PRKCB CTNNB1 PMC2696814__F1 Autophagy in the Pathogenesis of Disease ATG10 ATG3 ATG12 UVRAG AMBRA1 ATG5 PMC6485060__F2 CircRNA regulates cell proliferation CBL CDK6 ITCH E2F3 EGFR APC CDK2 PTEN IGF1R CTNNB1 FGF2 PMC4104550__F1 ALK signaling pathway with its cross-talk with other pathways involved in the resistance to ALK-inhibitors BAD ALK JAK3 GSK3B GRB2 MTOR FOS PMC11549395__F5 Regulatory network of the 32 DEMs and the 66 DEM-regulated DEGs was drawn by Cytoscape 3 CDC2 AURKA TRIP13 ESPL1 GPC1 COL1A2 CDC20 HAMP ORC1L HOXD10 KNL1 FZD4 CDC45 TTK WNT3 TWIST1 PMC4092085__F2 Na+, K+-ATPase-mediated signal transduction CSA2 EGFR GRB2 PMC5406167__F6 Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster MOCS3 SACS TMEM208 CTCF C6orf130 PHF12 ASCC2 PMC3808235__F1 Pathway-guided treatment in prostate cancer AURKA PTEN MTOR PMC8596126__F8 M6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons FZD3 YTHDF2 YTHDF1 PMC9124571__F2 Immune cells in cardiac repair and regeneration IL10 CCR2 CCL7 IL18 IL4 IL17A CCL2 MERTK PMC3188704__F1 Regulation of cell migration by signaling endosomes CDC42 TIAM1 EGFR ARF6 RHO SRC PMC7986631__F1 Cannabinoid biosynthesis including polyketide and isoprenoid precursor pathways IPP HEL-S-5 H1-5 PMC2762604__F11 Proteomic and Phospho-Proteomic Profile of Human Platelets in Basal, Resting State: Insights into Integrin Signaling BTD PDPK1 HEL-S-69p SRC PMC5713906__F1 Hh signaling and how pathogens may modify pathway activity MUC5AC FOXC2 JAG2 SMO TWIST2 MYC IGFBP6 IL1B PMC4095756__F2A GRK2 – A Link Between Myocardial Contractile Function and Cardiac Metabolism GRB2 MTOR IRS1 PMC3324133__F1 Insulin receptor (INSR) belongs to a family of receptor tyrosine kinases that includes the receptor for insulin-like growth factor 1 (IGF-1R) STAT3 BAD CAMKK2 INSR MTOR IGF2 EIF4E PMC3390632__F1 Overexpression of the Coq8 Kinase in Saccharomyces cerevisiae coq Null Mutants Allows for Accumulation of Diagnostic Intermediates of the Coenzyme Q6 Biosynthetic Pathway COG5 CRH COQ2 COG7 COG2 COQ5 COG3 PMC7369945__F1 Androgen “backdoor” steroidogenesis pathway HSD3B2 CYP21A2 HSD17B3 HSD17B6 CYP17A1 HSD11B1 PMC5209581__F5 Phosphatidylinositol 3-kinase (PI3K) pathway: Activation of class IA/B PI3Ks occurs through the stimulation of receptor tyrosine kinases, which is induced by insulin and the concomitant assembly of receptor–PI3K complexes BAD FOXO1 PTEN MDM2 MTOR PMC5960455__F1 Role of WNT/beta-catenin signaling in gliomas STAT3 HEL-S-133P APC LRP5 LRP6 CCND1 CTNNB1 PMC7488916__F6 Working model for amplified cross-talk between CXCR4 and EGFR to promote gastric cancer metastasis CXCL12 EGF EGFR CXCR4 PMC5124975__F3 Galectin-3 and IL-33/ST2 axis interaction in diet-induced steatohepatitis IL33 PMC8835853__F1 Cortical Dysplasia and the mTOR Pathway: How the Study of Human Brain Tissue Has Led to Insights into Epileptogenesis RHEB MLST8 TSC2 TSC1 NPRL2 TBC1D7 C16orf35 PTEN DEPDC5 EIF4E PMC2664745__F1 Molecular and cellular biology of enhanced cognition CDK5 KIF17 BDNF PMC5700087__F8 The proposed mechanism of BBB disruption in CNS TB SHH SMO PMC8156218__F1 Pentraxin 3: a powerful orchestrator in urinary tract infection PTX3 TLR4 MYD88 PMC6726833__F7 Functional roles of SALL4 in cervical cancer cells SALL4 APC GSK3B AXIN1 LRP5 LRP6 CCND1 CTNNB1 PMC12000890__F1 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology TGFBR2 TLR4 SMAD2 SMAD4 TGFBR1 PMC3356080__F4 Factors and molecular mechanisms that influence ecdysone synthesis and the timing of critical weight attainment TSC2 TSC1 SMAD2 PTEN PMC12000890__F3 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology NLRP3 TRAF6 MYD88 PMC12000890__F2 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology RB1 TSC2 ULK1 PMC10379125__F5 Transcriptome-Wide Identification and Response Pattern Analysis of the Salix integra NAC Transcription Factor in Response to Pb Stress WAS UST PMC12000890__F4 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology SIRT3 KEAP1 PMC4401249__F5 DIANA miRPath analysis of target genes for miRNAs downregulated in AD blood SYK BAD PDGFA TNFSF6 PRKCZ RBL2 PTEN CD19 MTOR INS RAC1 RHEB TSC2 CDK6 BCR CLU PI3 APP LAMA4 MDM2 GAB2 PMC12024652__F1 Signaling pathway of necroptosis and its PTMs PRMT1 TBK1 TRADD ZFP91 ITCH MLKL ULK1 OTULIN TAB3 PTMS SIRT2 SKP2 PLK1 PELI1 MIB2 RIPK1 APP SRC USP21 PPM1B CYLD SMYD2 RNF146 TNF RIPK3 TRIM25 HAT1 SENP1 PPP1R3G USP22 JAK1 CDC37 TRAF2 SIRT1 FADD PMC4401249__F4 DIANA miRPath analysis of target genes for miRNAs upregulated in AD blood GRIA2 GRINA CREBBP KRAS PRKCB PMC8635864__F3 To B (Bone Morphogenic Protein-2) or Not to B (Bone Morphogenic Protein-2): Mesenchymal Stem Cells May Explain the Protein’s Role in Osteosarcomagenesis BGLAP SMAD1 ALPL DKFZp781O1323 WNT3A APC BMP2 LRP5 SP7 LRP6 RUNX2 CTNNB1 PMC8635864__F1 To B (Bone Morphogenic Protein-2) or Not to B (Bone Morphogenic Protein-2): Mesenchymal Stem Cells May Explain the Protein’s Role in Osteosarcomagenesis BGLAP SMAD1 ALPL COL1A1 DKFZp781O1323 BMP2 SP7 SMAD6 SMAD4 RUNX2 PMC8301038__F2 Redox Regulation of Lipid Mobilization in Adipose Tissues INS NOX4 PMC9365139__F4 The effects of ATRA treatment of hyperoxic A549 cells TH TRO APP PMC3579143__F8 The regulatory role of IRAK-M in TLR-IL-1R signalling SOCS1 IRAK1 TRAF6 EIF4E MYD88 PMC10313199__F3 Advances in epigenetic modifications of autophagic process in pulmonary hypertension HDAC3 HDAC1 FOXO1 HDAC5 HDAC7 HDAC11 MTOR ATG5 HDAC2 SIRT1 HDAC6 PMC7337964__F9 Expression profile of genes in Hepatic fibrosis pathway for Pre_S cohort FAS CSF1 IGFBP4 COL3A1 CXCL8 CXCL3 TGFBR1 FGFR2 TGFBR2 BAMBI COL1A1 TLR4 FLT1 KDR IFNGR1 COL1A2 COL11A2 IL10RA VEGFA COL18A1 IGF1 IGFBP5 ECE1 NFKB1 EDN1 COL27A1 COL16A1 BCL2 TNFRSF11B PMC8064355__F7 Schematic illustrating the suppressive effect of 6M3HSC (compound 3) against the RAGE-RAGE ligand signaling pathway CDC42 HMGB1 DOCK7 TIRAP C2 IRAK1 RHO RAC1 MYD88 PMC5464971__F7 “Tissue Development, Cardiovascular System Development and Function, Organismal Development.” This was the top most associated network according to IPA core analysis of the TM gene input set which included the microarray study by Fan et al CAV2 SMAD1 THBS1 TGFBI DKFZp781O1323 PPIF AIP SPOCK1 COL13A1 SFRP1 VCAN ACTA2 MGP BMP4 GREM1 BMP2 MT1E GJA1 PMC8762193__F1 Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly IFNG STAT3 STAT1 PMC5798893__F7 Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRB signaling pathways in tumor vascular remodeling PDGFRA FGFR1 PC FGF2 FGFR2 PMC2219351__F1 Gluten affects epithelial differentiation-associated genes in small intestinal mucosa of coeliac patients DGKD EGFR MTCP1 GSK3B PTEN SET CTNNB1 PMC7141786__F1 Proposed model for the molecular events and mechanisms underlying the protection of autophagy against alcoholic liver disease ALDH2 PINK1 TFEB PMC2323197__F1 Immunosuppression in islet transplantation IL2RB IL2 PMC7904922__F6 Photoreceptor metabolic reprogramming: current understanding and therapeutic implications GOT2 GLS HEL-S-162eP MAL HEL-S-32 ME1 HEL-75 HEL-S-44 PMC7904922__F4 Photoreceptor metabolic reprogramming: current understanding and therapeutic implications TSC1 PTEN HIF1A SIRT6 PMC9498834__F2 Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products HEY2 ADAM10 PMC2842525__F2 IFNA signal transduction STAT1 STAT2 JAK1 TYK2 PMC11610372__F7 Mechanism diagram of berberine acting on tuft cells to relieve colitis IL25 TRPM5 PMC12125784__F6 Working model PHB2 TSC2 OPA1 OMA1 PMC8424144__F6 How Kcnma1 regulates bone formation through Wnt/Beta-catenin signaling APC RUNX2 CTNNB1 PMC6987096__F8 Schematic diagram that depicts platelet-induced estrogen biosynthesis in endometriosis HSD3B2 USF2 CRTC2 DUSP2 PMC9929508__F3 Microgravity and immune cells CD80 ATR ICAM3 ATM PMC2885101__F2 PI3K/Akt signaling pathway BAD IGF1 PMC3659082__F7 Insulin/IGF-1 Signaling, including Class II/III PI3Ks, Beta-Arrestin and SGK-1, Is Required in C. elegans to Maintain Pharyngeal Muscle Performance during Starvation UNC79 PMC8210242__F4 Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer ATR RAD51 BRCA1 BRCA2 ATM PMC4506602__F4 Chemical–protein interactions related to the VEGF signaling pathway CASP9 PIK3CA PLA2G1B PLA2G5 PTGS2 VEGFA PPP3CA KRAS PPP3CC PLA2G2A MAPK3 MAPK14 PLA2G10 NFATC3 PMC6378284__F6 WWOX controls TGFB, Hyal-2, and Wnt signaling pathways that cross talks with the Hippo signaling SMAD2 APC GSK3B SOX2 SMAD4 DVL2 MYC TGFBR1 TGFBR2 LATS1 LATS2 AMOT WWOX HYAL2 NF2 PMC9709458__F1 T cell function by protein S-acylation FAS PLCG1 FYN LAT STIM1 APC CSK GRB2 PMC6378284__F4 A schematic illustration of YAP/TAZ regulation of TE and ICM specification in preimplantation embryo CDX2 GATA3 PMC6796845__F3 Core molecular mechanism of non-apoptotic regulated cell death CDC42 KEAP1 PGAM5 GPX4 MLKL LPCAT3 FACL4 SLC7A11 MIF ARHA PARP1 RIPK3 GSDMD TICAM1 IKBKB NFE2L2 ALOX15 RIPK1 AIFM1 CA9 PMC6796845__F2 Extrinsic and intrinsic apoptosis HTRA2 BAX CASP9 DCC CASP8 TNFSF6 CYCS TNF BCL2L1 BCL2 TNFSF10 BAK1 APAF1 CASP10 DIABLO FADD PMC6345610__F3 Illustration of the role of FUNDC1-related MAMs under physiological conditions FIS1 FUNDC1 PMC4278244__F7 Model representing that Wnt/planar cell polarity signaling contributes to the association between pericytes and developing blood vessels via the Wnt5a-Fzd7-cdc42 axis CDC42 PC PAH PMC6378284__F2 Mammalian Hippo pathway signaling LATS1 LATS2 NF2 VGLL4 PMC8135154__F1 Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism RHEB NAPRT ULK1 NAMPT CASTOR1 SIRT1 PMC6667643__F2 Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis STAT3 CSF1 CDA GAD1 PLG POLI MIF TNF PMC3502787__F1 General features of the HER family EGF HBEGF BAD TGFA GSK3B MTOR PMC6453741__F4 Functional role of CLDN1 in signal transduction and EMT in liver disease MMP2 CLDN1 PMC5644891__F1 The leptin/melanocortin pathway SIM1 LEPR POMC MC4R NPY AgRP BDNF PMC5581966__F1 The auto-immune attack to the beta-cells in Type 1 diabetes mellitus IFNG STAT1 FAS TRADD APC IRAK1 JAK1 TRAF6 TRAF2 FADD MYD88 PMC5154833__F1 Therapeutic Relevance of mTOR Inhibition in Murine Succinate Semialdehyde Dehydrogenase Deficiency (SSADHD), a Disorder of GABA Metabolism TH BAAT DHH PMC3065553__F5 Metabolic pathway for pitavastatin UGT1A1 UGT1A3 CYP2C9 CYP3A4 UGT2B7 PMC8879554__F2 Network-Assisted Systems Biology Analysis of the Mitochondrial Proteome in a Pre-Clinical Model of Ischemia, Revascularization and Post-Conditioning SUCLA2 ACO2 OGDH DLD PMC5804098__F4 Pharmacologic Reprogramming Designed to Induce a Warburg Effect in Porcine Fetal Fibroblasts Alters Gene Expression and Quantities of Metabolites from Conditioned Media Without Increased Cell Proliferation PCK2 PHGDH PSAT1 TIGAR PSPH PMC7599793__F1 Summary of Wnt/Beta-catenin, Hedgehog and hypoxia inducible factor (HIF) pathways and their downstream mediators in the liver P4HA2 GSKIP APC LRP5 SOX2 IHH LRP6 TWIST2 WNT9B HIF1A CTNNB1 VHL BCL9 PIG59 SOX9 SUFU AHR SHH CCND1 GLI3 PMC5445595__F3 T cell gene expression analyses of T cells from sargramostim-treated or placebo-treated PD patients PPARG FAS TP53INP1 IL3 PERP TNFSF6 LRRC32 IL6 IRF4 IRF8 RORC IL24 UTS2 IGSF6 PMC6172014__F1 Fibroblast growth factor receptor (FGFR) structure, FGFR signaling, and specificity of the FGF–FGFR interaction FRS2 GRB2 IL1B PMC8588006__F4 Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis TLR1 MYD88 PMC12058791__F2 Natural products target ROS, P53, mTOR, NFKB, Beta-catenin and other signaling pathways to regulate apoptosis and play a role in intervening CRC BAX CGA MTOR CTNNB1 PMC12058791__F1 Action of natural product-targeted modulation of PCD for the treatment of CRC MLKL ULK1 ATG14 DFNA5 MTOR ATG101 RIPK3 GSDMD NLRP3 AMBRA1 RIPK1 ULK2 FADD PMC3676112__F7 Translation regulation of the mTOR signaling pathway and translation process EIF4B RPS5 RPLP0 RPS14 BRAF EIF4H EEF1G RPS27A HIF1A MTOR ETF1 EIF4E RHEB RPL3 TSC2 EIF3G RICTOR TSC1 RPL17 RPS13 EIF3J EEF2 RPL9 EIF5B PMC12026011__F1 Pyrimidine synthesis pathway including the two process of pyrimidine nucleotides synthesis: the novo pathway and the salvage pathway CAD CDA OMP DHODH PMC7007431__F1 Serine–glycine-one-carbon metabolism: vulnerabilities in MYCN-amplified neuroblastoma MTHFD1 FBXW7 PHGDH SHMT1 PSAT1 ATF4 PSPH PMC7710720__F3 Sortilin and its soluble form (sSortilin) in colorectal cancer C2 SRC PMC10040131__F7 PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer AGR2 ANGPTL4 LOX PHF6 VEGFA BPTF AQP1 PMC7710720__F2 Neurotensin pathway in digestive cancers and clinical applications: an overview CDC42 NTS EGR1 SP3 NTSR1 RHO SRC PMC6721562__F3 Direct and indirect epigenetic control of cellular metabolism HK2 FBP1 PTEN HIF1A MTOR VHL PMC10517567__F8 Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression CCND3 DVL1 JUN ITCH APC GSK3B PPP2CA DVL2 MYC CTNNB1 TLE2 BCL9 CCND2 FOSL1 LEF1 CCND1 WIF1 PMC535924__F3 Molecular events shown by associated predicates GRB2 IRS1 PMC8702371__F3 Precision Nutrition Algorithm for Cancer PIK3CA APC PTEN PMC3342359__F2 Autophagy induction by TLR stimulation TLR4 TLR7 MYD88 PMC12058791__F4 Natural products play a role in intervening in CRC by targeting signalling pathways such as Nrf2, GPX4, NLRP3, RIPK1, and RIPK3 and regulating different forms of cell death mechanisms such as Ferroptosis, Pyroptosis and Necroptosis NLRC4 RIPK3 NLRP1 GSDMD NLRP3 STEAP3 MLKL GPX4 AIM2 RIPK1 HEL-S-64p FADD PMC3342359__F1 Three types of autophagy and cellular and molecular events in an autophagic pathway ATG10 ATG3 ATG12 PMC12058791__F3 Natural products target ROS, PI3K/AKT, AMPK, and LC3 signaling pathways to regulate autophagy and play a role in intervening in CRC ATG3 ULK1 MTOR PMC5824384__F1 Role and mechanism of Twist1 in renal, pulmonary and skin fibrosis BMI1 BRD4 CXCL12 TG CXCL2 CTNNB1 PMC3410437__F2 KEGG pathway of the renin-angiotensin system AGTR2 REN MME NLN CPA3 LNPEP CTSA ENPEP CTSG ACE2 PMC7555423__F7 G Protein-Coupled Estrogen Receptor Mediates Cell Proliferation through the cAMP/PKA/CREB Pathway in Murine Bone Marrow Mesenchymal Stem Cells CDK6 CCNE1 GPER CDK2 CCND1 PMC7804500__F4 PPI network of the 37 enriched genes from KEGG pathway analysis by Cytoscape CDC42 PPARG FAS TGFB1 HGF LEP HIF1A CCL2 MAPK3 MAPK14 IFNG TLR4 MMP2 ATM IL1B MAPK1 NOS2 IL10 CD14 MMP9 VEGFA FOS TLR3 NFKB1 BCL2 BDNF PMC6773509__F2 Toll-like receptor signaling – general features of the canonical pathway MAP3K7IP1 TIRAP IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC3826519__F8 Deregulated genes upon miR-10b overexpression in FaDu cell line GML PCYT1B LMO2 PSPN LRRN4 PAX4 RASSF3 WSB2 NHLH1 MSRB1 RPL38 MYC TCF3 YME1L1 HSF1 TINAGL1 GFRA4 ETV7 GJB3 FKBP6 RAX TCF23 PMC8745479__F1 Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease CDC42 DAB1 VLDLR GSK3B PMC8434408__F4 Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells RAD52 REST RAD50 RAD51 BRCA2 BLM SSB SYCP3 BRCA1 MUL1 ATM PALB2 EME1 PMC8434408__F3 Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells LIG1 NEIL2 FEN1 PCNA NEIL3 POLE MBD4 TDG MPO PMC3365728__F9 RANKL-induced actin ring organization in mature OCs SYK SRC TRAF6 PMC5555796__F2 Metabolic Disorder Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism ACLY PINK1 GLS CTH GLO1 PARP1 OGDH F2 HEL-S-162eP PC BDNF HEL-S-64p NNT PMC5647101__F2 The co-expressing network of differentially expressed lncRNAs and mRNAs CXNA E2F7 PRIMA1 TFRC SPAST STON2 tmp_locus_29 PIGX PDE4D TMPRSS11D PAH CSTA NMNAT3 BNC1 YEATS2 MCC ASPN KRT14 MYNN LCE3D UTY KRTDAP S100A2 hEMMPRIN IRF6 TSLP ABCF3 HOXD11 PARL GJB6 SBSN KRT13 FAT2 PMC8434408__F5 Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells MSH6 MLH3 MSH2 MSH3 PMS2 PCNA SSB PMC10758489__F1 Metabolic reprogramming in the tumor microenvironment: unleashing T cell stemness for enhanced cancer immunotherapy HEL-S-61p MTOR MTR PMC6395542__F2 Dysregulated cholesterol homeostasis drives inflammasome activation ABCG1 NLRP3 AIM2 ABCA1 MVK PMC4712465__F1 Scheme showing role of pro and anti-inflammatory bioactive lipids in IBD HMGB1 IL4 MIF PMC8006293__F9 Depletion of CX3CR1 leads to increased activation of the necrosome in PMNs RIPK3 HMGB1 CXCR1 MLKL TLR4 IL33 CR1 PMC3859188__F4 Pancreatic cancer initiation pathway for simulation setting (III) MAPK1 CASP9 BAD AKT3 CS MAPK8 KRAS RAC1 ARAF BCL2L1 RALA PIK3R4 NFKB1 CHUK MAP2K1 RALBP1 PMC5214937__F2 Proposed T MAVS TLR3 TLR9 TLR8 MYD88 PMC2659383__F3 SHH signaling pathway components that have been employed in the production of genetically engineered mouse models SUFU SHH SMO MYC PMC5884276__F1 Characteristic enzymes for the synthesis of isopentenyl diphosphate (IPP)/dimethylallyl diphosphate (DMAPP) and the formation of the isoprenoid diphosphate chain IPP PMC9521228__F2 Successful use of eculizumab for treatment of thrombotic microangiopathy in pediatric acute SARS-CoV2 infection and multisystem inflammatory syndrome in children MASP2 C2 C1S C1R PMC2958907__F1 Web-accessible DC pathway navigator RP1 RIGI TIRAP TRAF2 PMC4216593__F8 Although distal 11q copy number loss, from band 11q14 to 11qter has been reported in many types of tumors, its significance had not been investigated until our previous study () ATR CHEK2 CHEK1 ATM PMC7472658__F6 Clinical implications of PTEN loss in prostate cancer RHEB TSC2 RICTOR TSC1 PTEN MTOR IRS1 PMC4252583__F3 HDL and Cognition in Neurodegenerative Disorders ABCA1 PMC7600430__F7 Schematic diagram illustrating the proposed mechanism of (−)-agelamide D-mediated radiosensitization in HCC ATF4 EIF2A PMC11733248__F2 Current therapeutic targets in gastric cancer and GEJ adenocarcinoma DKK1 MTOR PMC4590620__F4 Alcohol’s effects on fibrogenic pathways in hepatic stellate cells (HSCs) BAMBI TLR4 CD14 LBP PMC7400404__F11 Complexin 2 in green box was mapped onto the synaptic vesicle cycle pathway (04721) generated by KEGG PATHWAY (Organism: Danio rerio) SYP PMC4590620__F2 Alcohol’s effects on pro-inflammatory pathways in liver macrophages (i.e., Kupffer cells) TLR4 CD14 LBP IL1B PMC5430631__F6 Distribution of Turkish galls target proteins on the compressed UC pathway APC FOXP3 PMC7329534__F8 Pathway analysis A) Pathway analysis for upregulated (a) and downregulated (b) miRNAs and their respective mRNA targets PXN ATP6V1A PIK3CD GSK3B DUSP9 MAPKAPK3 PIK3R1 MST1R MAPK8 LRIG1 VEGFB EREG PDPK1 FGFR4 FGFR1 AP2A1 PRKCA AP2A2 CSNK2A1 COL4A1 PLOD3 RDX RNF41 MAPK1 VAV3 FRS2 ROCK2 AXL SPTBN2 SPTBN1 NTRK2 DUSP4 PLXND1 VEGFA ITGB3 FURIN RELN POLR2H IRS1 COL2A1 EFNB1 DAB1 RICTOR USP33 SPRED1 NEDD4 GRAP PLXNA1 RAPGEF1 PLXNA3 CALM1 PFN2 GRB2 BDNF BAIAP2 COL5A2 RET GRIN2B HGF LYPLA2 MAPK13 EGFR WASL AKT3 NUMB PLXNA4 COL3A1 EPHA7 DST DUSP3 SHANK3 EPHA8 SLIT2 SEMA6D TUBA4A INSR PXDN DUSP16 DUSP7 TUBA1A COL14A1 RAB4B EPHA4 PLXNC1 WWP1 RBFOX2 VRK3 SEMA3A PPP2R1B EPN1 CHEK1 MAP2K1 UNC5A PMC8027215__F4 Key genes and metabolic pathways in Lokiarchaeota POR ACADS HEL-S-162eP ACD GCK PMC5829268__F2 Schematic demonstration of TCR signaling ZAP70 JUN LAT IL2 GRB2 FOS PMC4648381__F2 MGMT and other DNA repair mechanisms deal with DNA damage produced by the alkylating agent TMZ in cancer cells MPG PARG ELL PARP2 MGMT PMC11658435__F7 Adipose-derived stem cell exosomes attenuates myofibroblast transformation via inhibiting autophagy through TGFB/Smad2 axis in oral submucosal fibrosis SMAD2 SMAD4 PMC10778515__F6 The Rap1 signaling pathway NGF NRAS KDR GRB2 PMC9359062__F1 Anaplastic lymphoma kinase-special immunity and immunotherapy STAT3 HGF ALK TNFSF13 BATF3 IRF4 MTOR TNFSF10 PMC6456408__F7 Type I IFN signaling and production in Mtb-infected cells STAT1 IRF9 IRF3 PMC7919457__F3 Gene fusions in pancreatic cancer RAF1 BRAF NTRK3 FGFR2 ALK TRIM24 CDH6 G3BP2 PDZRN3 ROS1 PFKFB4 DNAJB1 COL14A1 RRBP1 ATP1B1 KANK1 KRAS EML4 CCDC6 ARAF SLC4A4 ERBB3 NRG1 RAP1A CDC42BPB NTRK1 Nbla10317 GRB2 SND1 RET PMC7570361__F1 Biosynthesis of steroids in mammals HSD3B2 SRD5A2 HSD17B3 HSD17B6 CYP17A1 CYP11A1 PMC8131524__F1 Exploring the Gut-Brain Axis for the Control of CNS Inflammatory Demyelination: Immunomodulation by Bacteroides fragilis’ Polysaccharide A ICOS TLR4 APC GSK3B IRF3 MYD88 PMC5916949__F6 A schematic depicting the potential involvement of MALAT1 in regulating inflammation through epigenetic mechanisms in diabetic retinopathy SUZ12 EED EZH2 PMC4211625__F1 Tyrosine phosphatase SHP2 is required for the proper timing of neurogenesis and gliogenesis and the balance between them during CNS development STAT3 CNTF STAT1 LIF GRB2 MYC PMC8699088__F2 Senescent Cells in Cancer: Wanted or Unwanted Citizens IL1R1 CGAS MTOR GATA4 PMC6047270__F1 Cell cycle arrest induced fibrosis ATR TGFB1 CDK6 CDK2 ATM CDK4 PMC7311088__F1 Synthesis of Fluorinated Amide Derivatives via a Radical N-Perfluoroalkylation–Defluorination Pathway TH ENO1 PMC6167191__F5 Dendritic Spine Elimination: Molecular Mechanisms and Implications CXCR1 CDK5 MEGF10 EPHA4 ARHA MERTK PMC11039819__F2 Interplay between autophagy and cGAS-STING signaling and its implications for cancer TBK1 CGAS IRF3 IFNB1 PMC1483059__F10 Peculiar structure of the juxtanuclear actin network CDC42 ARHA SRC RAC1 PMC3763461__F1 Hypothetical model explaining the pathway through which mutated htt (mhtt) causes OMM permeabilization BAD OPA1 BNIP3 BDNF PMC6584619__F8 mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGFB1––induced collagen biosynthesis PHGDH PSAT1 ATF4 HEL-S-51e PSPH PMC8392056__F1 Molecularly Targeted Therapies for Gastric Cancer. State of the Art HGF EGFR MTOR PMC7997471__F5 Proposed mechanism is depicting the effect of IMP inhibiting inflammatory effects STAT3 STAT1 KEAP1 TLR4 CD14 JAK1 LBP HEL-S-44 MYD88 PMC4739752__F1 Repression of DNA-damage signaling pathways at telomeres RAD52 ATR RAD51 H2AX POLI RIF1 MDC1 PARP1 XRCC3 MAD2L2 RNF168 ATM POT1 PMC3924780__F1 Scaffolding Proteins: Not Such Innocent Bystanders CDC2 GSK3B LRP6 PLK1 CTNNB1 PMC3432564__F2 Transmembrane CLRs involved in antifungal immunity and their intracellular signaling pathways SYK RAF1 CARD9 MYD88 PMC6167191__F7 Dendritic Spine Elimination: Molecular Mechanisms and Implications BAX BAD ARC BDNF PMC3518628__F1 Interplay between Wnt/Beta-catenin signaling and HIV: Virologic and biologic consequences in the CNS PIGO APC CTNNB1 PMC3252742__F4 Apoptotic pathway in cardiac myocytes BAX CASP9 BAD CASP3 DIABLO PMC3518628__F3 Interplay between Wnt/Beta-catenin signaling and HIV: Virologic and biologic consequences in the CNS IFNG POLI AXIN2 CTNNB1 PMC11760468__F1 Ras signaling and its involvement in myeloid malignancies FLT3 MPL BAD NF1 GSK3B GRB2 MTOR GAB2 CTNNB1 EIF4E PMC6317740__F1 Dishevelled: a masterful conductor of complex Wnt signals CDC42 LRP5 LRP6 RHO CTNNB1 PMC4573074__F1 Regulation of autophagy.Notes: mTOR is one of the most important regulators of autophagy ATG101 ATG10 ATG3 ATG12 ULK1 BCL2 PTEN ATG5 PMC4056054__F1 Co-culture with M38 melanoma upregulate interferon signalling pathways IFNG STAT2 MSC IRF1 FOS PMC3084393__F10 Proposed diagram for Alpha-mangostin-induced apoptosis in COLO 205 cells FAS BMF PMC4013479__F1 A simplified working model of the c-di-GMP signaling pathway in B RRP1 HK2 PMC7353358__F2 Phytochemicals activate the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway KEAP1 AHR PMC4534795__F12 Selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression TH C2 NRF1 CP PMC6888825__F7 Proposed transcriptional regulatory system for VA and SA catabolism in Sphingobium sp MGA LIG1 PDC PMC7497066__F1 Frequent mutations in positive (green) and negative (red) regulators of the NF‐KB pathway in MM CD79B CD79A LTBR BCL10 BCR RELB TRAF5 TRAF3 TRAF6 CYLD TRAF2 PMC2741634__F2 How location governs Toll like receptor signaling TIRAP TLR4 TRAF6 MYD88 PMC11909974__F10 Integrative analysis of transcriptome and metabolome reveal molecular mechanism of tolerance to salt stress in rice MAL KL PMC9125221__F6 Identification of Candidate Genes Associated With Tolerance to Apple Replant Disease by Genome-Wide Transcriptome Analysis RGL3 LEP PMC6738915__F6 Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae RBX1 KEAP1 MAF PMC7393266__F2 Major anti-tumor mechanisms of EGFR monoclonal antibodies TF BAX H2AX EGFR CDK2 PMC3616148__F2 Roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability RAD18 REV1 PCNA USP1 POLN PMC7359322__F6 Heat map and DEGs expression profiles of genes associated with phenylpropanoid biosynthetic pathway, (B) heat map showing the different expression profiles of genes involved in the terpene biosynthesis pathway IPP CAD ME2 MVP MVD MVK PMC3616148__F3 Roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability ERCC1 FANCD2 REV1 FAN1 SLX4 EME1 PMC6215570__F6 Akt/mTOR pathway and regulatory effects of galangin and pinocembrin on the phosphorylation of key proteins RPS6 TSC2 PTEN MTOR PMC3266773__F10 CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression RUNX1 BCR CD27 TNLG8A VEGFA TNIK LEF1 TRAF2 CTNNB1 PMC3762088__F2 Regulation of autophagy by oncogenes and tumor suppressors TSC2 TSC1 BCL2 PTEN PMC5700962__F8 Parkinson disease pathway(red, up-regulated) RFWD2 HTRA2 TH F2 SNCA PMC5700962__F7 Six genes are enriched in the top 2 significant pathways(red, up-regulated) LTB ACTR2 LEP PRL LEPR BMP2 EPO KIT TPO EDAR TNLG7C PMC7450308__F1 Increasing ROS triggers mitochondrial damage related to ferroptosis under cysteine starvation TF GPX4 PMC2822975__F1 Asbestos has pleiotropic effects on cell signaling pathways TSC2 TRADD EGFR PTEN MTOR PMC9475360__F2 KRAS as a Key Oncogene in the Clinical Precision Diagnosis and Treatment of Pancreatic Cancer LATS1 GRB2 MTOR KRAS PMC9475360__F1 KRAS as a Key Oncogene in the Clinical Precision Diagnosis and Treatment of Pancreatic Cancer SOS1 GRB2 MTOR KRAS PMC10491753__F5 Pictorial model of intracellular redox balance facilitated by compartmentalization of amino acid biosynthesis enzymes within optimally sized peroxisomes GPD2 GPD1 PMC5771206__F6 Intramuscular fat metabolism LPL THRSP FABP4 CPT2 PMC10242330__F2 Autophagy: A challengeable paradox in cancer treatment RHEB TSC2 TSC1 AMBRA1 ATG14 BCL2 PMC7646705__F1 Schematic outline of lipid oxidation and impaired lipoprotein metabolism in psoriasis ABCG1 LOX PON1 LDLR PMC8972277__F5 Aspirin attenuates liver fibrosis by suppressing TGFB1/Smad signaling SMAD2 SMAD4 PMC6444613__F1 Metabolic pathway of propionyl-CoA and methylmalonyl-CoA IDE CBLC MTRR MMADHC LMBRD1 PMC4453439__F1 The signalling pathways implicated in fusion-positive ARMS progression PAX3 FOXO1 FGFR4 PTEN IGF1R PAX7 IGF2 PMC3088722__F6 Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells TBX2 HEL-S-76p BIRC6 TGFBI PEG3 GAS2 CDKN2D CTCF CCNG1 CKS1B LATS2 NDN SCMH1 ZNF346 CRADD CDK4 CLIC4 TP53INP1 CASP2 RBL2 PRIM2 PTP4A3 EI24 DDB2 CDKN1A PMC7606576__F3 WNK/SPAK/CCC signaling pathway in cell volume homeostasis WNK1 OSR1 WNK3 PMC3672665__F1 Epithelial cancer cell inflammatory response STAT3 PTEN CYLD PMC3842443__F2 Molecular Targeted Drugs and Biomarkers in NSCLC, the Evolving Role of Individualized Therapy CDC42 ERBB3 RHEB TSC2 HGF TSC1 RHO RAC1 IRS1 PMC5987629__F1 Schematic diagram of the heterologous synthesis pathway for the production of geranyl acetate in the engineered S MAF1 IPP IDI1 PMC10526800__F3 Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond PCSK9 CKAP4 IGF1 DKK1 LRP5 LRP6 FLOT1 PTEN IGF1R MTOR PMC8557215__F7 Schematic drawing of LPS function in PDAC TLR4 LBP MYD88 PMC9133627__F1 Advances on Innate Immune Evasion by Avian Immunosuppressive Viruses CGAS MAVS STAT2 IFNAR2 IRF9 IRF7 TRAF3 TYK2 PMC3071831__F7 Targeted Morphoproteomic Profiling of Ewing's Sarcoma Treated with Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors: Response/Resistance Signatures RHEB TSC2 RICTOR FLI1 TSC1 IGF1 PTEN IGF1R MTOR PMC6328873__F1 State of art of neutrophil extracellular traps in protozoan and helminthic infections TRPM2 TLR4 HEL-S-11 IRAK4 MPO PMC7779655__F5 Copper-dependent mechanisms of cancer cell migration and metastasis ATOX1 LOX SRC CCND1 ATP7A PMC2749862__F5 Most prominently affected gene network in response to DEX in TM 86 cells ZFP91 PRPF4 NKTR ARMC8 BCLAF1 PMC7779655__F4 Copper-dependent mechanisms of oncogenic signaling ULK1 MTOR ULK2 PMC5024694__F1 Simplified model of the canonical Wnt pathway and inhibitors BCL9 APC GSK3B LRP5 LRP6 MTOR CTNNB1 PMC2749862__F6 Most prominently affected gene network in response to FA in TM 93 cells UBR7 LIMCH1 CDCA3 TMEM14A OIP5 PIR MT1E ANKRD36B PMC7794785__F5 Activation of MAPK pathways (highlighted in yellow), the guanyl cyclase pathway (highlighted in orange) and nuclear factorKB (highlighted in purple) by the adenosine A1 receptor (A1R) PREX1 GRB2 PMC7779655__F1 Cellular copper homeostasis in mammals FAM36A COA6 CCS DBH LOXL1 COA5 SLC25A3 ATP7B COX17 ATP7A ATOX1 LOXL2 LOXL3 LOX LOXL4 SCO2 COX19 COX11 HEL-S-44 CP PMC10836028__F9 Schematic figure showing that melatonin attenuates mechanical trauma-induced hepatic injury by inhibiting IP3R1-mediated MAMs formation via activating the melatonin receptor-ERK1/2-FoxO1 pathway FOXO1 PMC4851740__F3 Schematic model of signaling pathways implicated in tumor cell VM TF MMP14 EPHA2 MMP2 NODAL TWIST1 PMC2693232__F2 Unifying model of TGFB signaling in breast epithelium CDH2 CD44 TGFBR2 CAV2 CD24 HEL113 TGFA IGF1 SPARC PMC4614799__F1 Driver genetic lesions in papillary thyroid carcinoma PTEN MTOR PMC7581770__F2 Pathway annotation analysis of AVNFH patient cartilage transcriptomics and RANKL induced osteoclastogenesis transcriptomics TCIRG1 ABCC1 HEL-S-21 TCN2 PIK3R2 FHL2 MMADHC AMN MMAA MMACHC MAP2K6 MTHFD2 MCOLN1 ENOPH1 GCLM CTSK TRMT112 FOS PAPSS2 TNFSF11 TRAF1 TPMT LMBRD1 CDC42 RELB DHFR SLC46A1 MTOR ADI1 MRI1 TFRC NNMT MTHFD1L SLC25A32 CUBN AOX1 CTRB2 HEL-S-302 CTH CTRC SLC44A1 RAC1 CALCR MTHFD1 CBL NFKBIA PRSS1 MAP2K1 LYN ABCD4 TRAF2 PMC6017457__F3 Schematic representation of the unfolded protein response pathway ATF4 EIF2A PMC2690394__F2 Molecular targets of natural chemopreventive agents PTEN MDM2 GRB2 PMC5557355__F7 Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis EN2 EN1 MTOR PMC8721012__F5 New Antitumor Direction: Tumor-Specific Endothelial Cells CCL22 HSPA12B GSK3B MTOR CCL2 FGF2 PMC6522317__F2 Unfolding the Role of Calreticulin in Myeloproliferative Neoplasm Pathogenesis MPL HEL-S-99n FLI1 PMC8536918__F1 Comprehensive overview of extracellular vesicle proteomics in meningioma: future strategy SUFU EGFR SMAD2 APC SMAD4 SMO PTEN CTNNB1 PMC2627788__F5 Wnt/Beta-catenin signaling pathway in leukemia SALL4 APC GSK3B LRP5 LRP6 CTNNB1 PMC3314429__F2 miRNA-mediated immune regulation and immunotherapeutic potential in glioblastoma STAT3 EGFR PTEN PMC3663800__F8 New Algorithm for Integrated Analysis of miRNA-mRNA Interactions Based on Individual Classification Reveals Insights into Bladder Cancer EGF E2F2 E2F3 EGFR ERBB2 FGFR3 MDM2 CCND1 CDK4 PMC5154738__F2 Translational Control of Long-Lasting Synaptic Plasticity and Memory RHEB TSC2 RICTOR TSC1 PTEN MTOR IRS1 PMC7105607__F2 Impact of NFKB on MS animal models RELB ELL PMC7105607__F1 NFKB signaling cascade CD40 BCL10 TLR4 TAB3 RELB TRAF3 TRAF6 TNF TRAF2 PMC3663800__F7 New Algorithm for Integrated Analysis of miRNA-mRNA Interactions Based on Individual Classification Reveals Insights into Bladder Cancer RAF1 SHC1 SOS1 RASSF1 EGFR SPHK1 PRKCZ SHC2 PRKCH PRKCB PLCG1 SHC4 PRKCE PLCG2 SPHK2 PRKCA SHC3 NNT MAPK1 PRKCI PRKCQ SOS2 PDGFRA DAPK2 FGFR3 MAP2K1 MAP2K2 GRB2 PMC6558796__F3 Gene network analysis of RNA-Seq data from MDA-MB-231 and OVCAR3 cells DEPDC1 PCNA CKS2 IFIT1 IFIT3 KIF20A IFIT2 SKP2 CDCA8 MX1 CCND1 SMC4 TDRD7 SKA2 STAT2 PARP14 APC POM121 RSAD2 OAS3 XAF1 IFIT5 NUSAP1 SPRED1 THEMIS2 IRF2 GINS2 PDCD10 JAK1 TYK2 PMC4227170__F2 CD147 plays an important role in a variety of cells and tissues regardless of health or disease CD44 EGFR GC ABCG2 TNF PMC11718844__F2 Signaling by IL-23R STAT3 SGK1 FOXO1 RANBP1 STAT4 FOXP3 SATB1 IL23R TYK2 PMC6381934__F1 Metabolic pathways of 1,25(OH)2D and 27HC synthesis CYP2R1 CYP27B1 CYP24A1 CYP7B1 CYP27A1 PMC11718844__F5 Key approved pharmacological agents for the IL-23R pathway IL23R TYK2 PMC8052535__F1 Proteolysis and inflammation of the kidney glomerulus MASP1 C6 C7 C2 C1S C1R C9 C4A C4B_2 PMC8439382__F1 The UPR Pathway in the Pathophysiology and Treatment of Bipolar Disorder ATF4 EIF2A PMC3645655__F3 P53 and BRCA regulation of DNA repair represents a central component of altered cellular function in serous ovarian cancer ATR RAD51 SPARCL1 BRCA2 EVI1 PTEN MYC RB1 CCNE1 CSMD3 BRCA1 NF1 AMT ID4 WWOX PAX8 ATM RAB25 FAT3 PMC5433029__F1 Hypothetical schematic of the physiological and pathophysiological roles of Notch signalling in articular cartilage IL1RL1 ADAMTS5 ADAM10 NOTCH2 RBPJ NOTCH1 PMC7651136__F4 Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer CDC2 FOXM1 ATR WEE1 CDK2 ATM PMC5700962__F9 Breast cancer pathway(red, up-regulated) EGFR APC KIT PTEN SHE CDK4 PMC3217209__F1 Insulin Resistance, Hyperglycemia, and Atherosclerosis PIR APOB VCAM1 MTOR PMC7651136__F7 Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer HMGB1 ATR TLR4 EGFR IRF3 CPD XPC PMC7651136__F9 Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer PTEN MTOR MYC PMC4735799__F8 Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system EGF EGFR AREG PMC8590697__F7 Graphical abstract of the mechanism by which cetuximab enhances RSL3-induced ferroptosis by inhibiting the Nrf2/HO-1 axis through the activation of p38 MAPK EGF GPX4 EGFR KRAS PMC8704271__F1 Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model CXCL12 ATR CLSPN MTOR IFI44L SCN3A CKAP2 JAM2 TPM1 E2F3 GPR49 HEL-S-117 KIRREL3 UBA7 CYTL1 DOCK10 SGK1 KRT14 KSR1 SCAND3 MMRN1 PLEKHH2 KIF25 BEX1 PTGDR PDC SERPINB2 GDF9 PMC6683007__F7 Molecular mechanisms associated with acylcarnitine expression in substantia nigra 3 days post-TBI HMGB1 TLR4 GPR158 PMC8138567__F2 Curcumin as a Potential Treatment for COVID-19 TMPRSS2 STAT3 ADAM17 EGFR MTOR ACE2 PMC6584345__F4 TRAIL death receptor pathway and its regulation by bioactive peptides MCL1 PLVAP MEI1 FADD PMC6972648__F5 Evidence for a role of protein phosphorylation in the maintenance of the cnidarian–algal symbiosis TSC2 CRX AMFR VCP PMC6584345__F3 STAT3 signaling pathway and its regulation by bioactive peptides STAT3 MTOR SHE PMC8622906__F5 CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c.1085 Genotypes CD40 TH CD40LG CSF1R PMC5778467__F7 Biological pathways that engage TDP1 and TDP2 TDP1 PNKP SSB PARP1 PMC11350665__F7 Main biological pathway responses to acute Cd exposure in oysters MGST3 CD2 LAP3 FASN ABCC3 ABCA1 ABCB1 PMC6343200__F5 Current Strategies for Elimination of HIV-1 Latent Reservoirs Using Chemical Compounds Targeting Host and Viral Factors SMYD2 BRD4 L3MBTL1 SP1 MEPCE LARP7 RELA EZH2 SUV39H1 CDK9 PMC8750274__F2 Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer CDC2 GABARAP ULK1 UVRAG ATG14 BNIP3 FLCN TSC2 DKFZp762B153 CDK6 CDK5 ATG12 ATG9A TFEB CDK2 ATG5 CDK4 PMC9545958__F8 LncRNA AK018453 regulates TRAP1/Smad signaling in IL‐17‐activated astrocytes: A potential role in EAE pathogenesis SMAD2 SMAD4 TNF PMC9229972__F3 Network Approaches to Integrate Analyses of Genetics and Metabolomics Data with Applications to Fetal Programming Studies SLC16A9 HEL-S-62p C2 GC CS ACCS PMC9501218__F5 MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells TLR3 TLR4 PMC4107945__F1 RLR signaling pathway is shown TBK1 MAVS TRIM25 IRF3 USP21 PMC3620110__F6 Expression of GATA3 in MDA-MB-231 Triple-negative Breast Cancer Cells Induces a Growth Inhibitory Response to TGFß CDC2 AURKA CENPF ID2 PCNA MYBL2 CDT1 PRIM1 RBL1 BIRC5 CDKN1A MCM10 AURKB CDC45 INCENP WDR76 GADD45B CDCA8 CDK14 MCM2 CCNB1 TOP2A ASF1B PMC3944254__F5 Proposed model of hypoxia-induced cellular processes presumably leading to antifolate resistance CAD DHFR FPGS PMC8820521__F2 Introduction to DOK2 and its Potential Role in Cancer EGF EGFR CSK MTOR SRC PMC12096540__F1 Key reactions involved in glycerolipid synthesis in plants LPA GAL FAS PC PMC4384471__F4 Induction of interferon (IFN) and its antagonism by viral proteins CGAS MAVS IRF3 IRF7 PMC8495158__F2 Study on Transorgan Regulation of Intervertebral Disc and Extra-Skeletal Organs Through Exosomes Derived From Bone Marrow Mesenchymal Stem Cells POR COMP LEP PC APP PTEN PMC4384471__F2 Interferon (IFN) signaling via the JAK–STAT pathway IFNGR2 IFNGR1 IFNLR1 IFNAR2 IFNAR1 JAK1 TYK2 PMC11989373__F2 AMPK signaling pathway in brown adipocyte thermogenesis TFAM ADRA1A UCP1 PMC6783260__F1 Complement activation triggers neuronal damage NGF HEL-S-62p PMC3620110__F2 Expression of GATA3 in MDA-MB-231 Triple-negative Breast Cancer Cells Induces a Growth Inhibitory Response to TGFß AGR2 MCAM SMAD1 TGFBI CXXC5 INHBA FST ASAP1 DKFZp686P11128 TSN NEDD9 GATA3 PMC5065109__F2 Current hypotheses for IFNGamma-mediated effect on NSPC activity.Notes: IFNG binds to the IFNG receptor (IFNGR1 and 2) and activates Janus-activated kinases 1 and 2 and signal transducers and activators of transcription-1 (JAK-STAT1) pathway IFNG STAT3 STAT1 IFNGR2 IFNGR1 SHH JAK1 PMC5682975__F5 Proposed model of IRAK4 regulation of TLR7/8 signaling pathway in human monocytes is shown TLR7 IL6 TRAF6 TNF IRAK4 MYD88 PMC11240352__F1 Genetic and nongenetic mechanisms of CRC resistance to cetuximab HGF EGFR BRAF PTEN IGF1R PMC9455954__F9 Comparative Physiological and Transcriptomic Analyses of Two Contrasting Pepper Genotypes under Salt Stress Reveal Complex Salt Tolerance Mechanisms in Seedlings ERF COPE PROC PMC11083860__F8 FGF23/FGFR1cAklotho signalling pathway which mediates phosphorylation of NHERF1 NHERF1 FRS2 SGK1 SOS1 GRB2 FGF23 PMC3000288__F1 Schematic representation of the As cycle in the environment and plants ABCC1 PC SI ABCC2 PMC7396444__F4 Expression of DEGs involved in the apoptosis and autophagy signaling pathways CAD INS HRK FADD PMC1974867__F9 Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis VIP CFTR PMC11240352__F4 Cetuximab mechanism of action and summary of how RAC1 and RAC1B could contribute to the known mechanisms of cetuximab resistance in CRC PAK1 EGFR MMP3 IGF1R RAC1 PMC7569177__F9 Cell Cycle Pathway from the KEGG Pathway hsa04110 CDC2 CDC20 PCNA GSK3B SMAD4 ORC1L PLK1 SKP2 ORC2 RAD21 CDK7 CDK2 MDM2 PMC6267225__F2 Core analyses network predictions for HBoV-infected CuFi-8 cells THBS1 SERPING1 FOXO1 PLA2G6 CNNM4 SIX2 ARHGEF2 AKAP12 RPL13 NEDD9 NFKBIZ PMC9693457__F2 Old and New Facts and Speculations on the Role of the B Cell Receptor in the Origin of Chronic Lymphocytic Leukemia EGF BCR EGFR PMC9693457__F1 Old and New Facts and Speculations on the Role of the B Cell Receptor in the Origin of Chronic Lymphocytic Leukemia SYK BTK PLCG2 MTOR PMC5553878__F6 Proposed model by which CCR7 regulated NFKB/VEGF pathway and induced angiogenesis in esophageal squamous carcinoma cells VEGFC CCR7 VEGFA PMC9687478__F1 Antiviral Innate Immune Responses in Autoimmunity: Receptors, Pathways, and Therapeutic Targeting TBK1 CGAS MAVS TLR9 IRAK1 IRF3 IRAK2 IRF7 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC6038164__F1 RhoA/ROCK1/LIMK2/Cofilin signaling pathway LIMK2 ROCK1 ARHA PMC7223178__F1 Mammalian TLR signaling pathway TBK1 LTA TIRAP IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 TLR10 TNLG7C PMC5474286__F1 Schematic representation of the immune cells involved in Mycobacterium tuberculosis infection HEL-S-92n CD80 IL1B PMC5915337__F4 Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer MSH6 RAD51 PCNA SMAD4 IGFBP2 PTEN TIGAR KRAS IRS1 EIF4E TSC2 EEF2K TSC1 CCNE1 INPP4B SRC CCNB1 NOTCH1 CDK4 PMC4057133__F6 Summary of signaling events leading to PRKD2-dependent induction of senescence in p53wt and p53mut GBM cells PRKD2 CDK2 CCND1 CDK4 PMC4523434__F1 Endoplasmic reticulum quality control in cancer: friend or foe OS9 SEL1L XBP1 PMC3913938__F7 Suggested mechanisms of synergistic cytotoxicity of [Gem+Clo+Ed] combination in lymphoma cells based on the previously reported data and our present results CASP9 CASP8 CASP3 ATF2 FADD PMC2233667__F6 Computational and Experimental Analysis of Redundancy in the Central Metabolism of Geobacter sulfurreducens POR PC CS PMC11174978__F3 Understanding Fibrous Tissue in the Effective Healing of Rotator Cuff Injury MMP7 MMP14 COL1A1 COL1A2 SMAD2 APC GSK3B SMAD4 COL3A1 CTNNB1 PMC7751853__F6 Bergenin protects pancreatic beta cells against cytokine-induced apoptosis in INS-1E cells STAT1 IL1B FADD PMC8986524__F3 Molecular mechanisms underlying the emergence of polygenetic antifungal drug resistance in msh2 mismatch repair mutants of Cryptococcus VPS16 VPS39 SNX3 PMC1560097__F3 Light-cycle of rhodopsin MAX PMC4914571__F5 Gene of the month: SMARCB1 CDC6 MYC CTNNB1 PMC8976844__F6 Mechanism graph of the regulatory network and function of miR-30c CD44 BCL9 CTNNB1 PMC7987693__F1 TGFB signaling pathways in EMT CDC42 CDH2 SMAD2 SMAD4 MMP9 MTOR ARHA TRAF6 RAC1 CTNNB1 MMP2 ZEB2 GRB2 PMC309045__F1 CRP-dependent (A) and CcpA-dependent (B) carbon catabolite repression pathways and the Ntr regulatory pathway (C) CRP HPR HP PMC6923180__F6 Schematic diagram of the pathway for OXT inhibition of CRC metastasis OXT OXTR CCL2 PMC6362084__F5 Activated TLR4 signal inhibited by neurosteroids HMGB1 TLR4 TRAF6 MYD88 PMC4785873__F3 Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons KRTCAP2 PFDN1 BRF2 HNRNPUL2 NOC2L PHC1 SRSF6 CSTF2 PGRMC1 ZNF277 PMC6798880__F2 Oncogenic KRAS effector pathways TBK1 RALB AXL GRB2 MTOR KRAS PMC8603983__F3 Revisiting cancer hallmarks: insights from the interplay between oxidative stress and non-coding RNAs KEAP1 PRXL2A TUG1 PMC7300384__F2 Epigenetic and epitranscriptomic pathways depend on metabolism ACLY ACSS2 HDAC1 TET2 SIRT3 SIRT4 PDC NAMPT NMNAT2 HDAC7 HEL-S-26 GPS2 PMC5091819__F1 Fronto-striatal circuits originate in the frontal cortex and pass through the basal ganglia, which project via the thalamus back to frontal brain areas PDE1B GC PMC5524517__F1 Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia CLDN7 STAT3 PDIA4 MMP14 TIMP1 PLAUR IFITM1 SPARC MMP9 COL3A1 MYC KIF23 CLDN2 VCAN CTNNB1 CHI3L1 EPCAM ICOS TFRC COL1A1 F2R VCAM1 CEBPB PMC3146054__F2 Regulation of microsomal triglyceride transfer protein MTTP INSR PDK2 PMC9705465__F3 Hydrogen sulfide as a therapeutic option for the treatment of Duchenne muscular dystrophy and other muscle-related diseases ETHE1 SUOX DAO PMC4259167__F1 Anti-tumor functions of GD T cells CD40 CD83 FAS CXCL13 MICA MICB PMC3039688__F7 Mapping Protein Interactions between Dengue Virus and Its Human and Insect Hosts SOCS1 STAT3 IFNGR1 STAT2 IRF9 SOCS2 PTPRC SOCS3 PTPN6 IFNG STAT1 IFNGR2 IFNAR2 IFNAR1 SOCS5 IFNB1 JAK1 TYK2 SOCS6 PMC7002987__F1 Different signaling pathways regulating melanogenesis MC1R HGF PMC5483589__F5 Ror2-expression-responsive module AQP2 PLCB4 HEL-S-273 UBE2C MAPK13 CD36 RPS6KA2 F7 MAPKAPK3 PRKCZ CTSZ PPP3CA FLNA ABCA1 ATP6AP2 MME BCL10 TEAD3 CEBPB CREB1 NPAS2 MED30 PER2 MAPKAPK2 ROR2 DVL2 FURIN NR3C1 HEL-S-130P ADCY3 CSK MAPK10 ADFP NFYC ACTG2 PMC7402354__F2 Platelet signaling pathways that trigger ROS production TRAF4 SYK COX1 CD36 LYN SRC PMC3829165__F9 Schematic illustrating the signaling pathways for TGFB1-induced down-regulation of VE-cadherin and the inhibition of cell invasion in human trophoblast cells SMAD2 SMAD4 PMC9231053__F6A Estimation of Carbon Metabolism in Saccharomyces cerevisiae Acclimatized to Glycerol Assimilation with Quantitative PCR XK BOK PMC7002987__F3 Cytokines that inhibit or stimulate melanogenesis IL33 TNF IL1B PMC2794709__F2 O-GlcNAc and phosphate regulate the insulin signaling pathway at the plasma membrane OGT IRS1 PMC9340222__F2 Traditional Chinese Medicine in the Treatment of Chronic Kidney Diseases: Theories, Applications, and Mechanisms NLRP3 MTOR CTNNB1 PMC9464648__F2 From cerebral ischemia towards myocardial, renal, and hepatic ischemia: Exosomal miRNAs as a general concept of intercellular communication in ischemia-reperfusion injury DGCR8 HNRNPA2B1 AGO2 DROSHA PMC5271383__F2 Regulatory mechanisms of NLRP3 inflammasome assembly NLRP3 BRCC3 PMC11689543__F5 Inflammatory and immunoregulatory role of megakaryocytes in sepsis TH HMGB1 CGAS IL33 IL6 RHO IFNG TSLP GSDMD NLRP3 RHOB TLR4 PDC IFITM3 CCR7 CXCR4 PMC9686310__F6 A muscle cell and the proteins linked to protein turnover and quality control VMA21 LAMP2 SIL1 TRIM32 BAG3 DNAJB6 KIAA1632 SQSTM1 PMC11689543__F3 Enhanced thrombopoiesis in sepsis STAT3 ANGPTL4 TPO PMC10143456__F7 Dickkopf-1 Acts as a Profibrotic Mediator in Progressive Chronic Kidney Disease DKK1 LRP5 LRP6 PMC12170861__F4 Distribution of common targets in the main signaling pathways TRDN PLN TNC CERK HRC BCR PI3 MCU ChAT DDC DAO PMC5590044__F6 Schematic of anti-EMT pathway of Rb1 RB1 EP300 PMC9254539__F2 Lipid metabolism in tumor microenvironment: novel therapeutic targets HMGCR SQLE PMVK MVD PTEN MVK PMC6997842__F1 Brain-derived neurotrophic factor (BDNF) mediation in the anti-inflammatory and neuroprotective response of Alpha-melanocyte-stimulating hormone/melanocortin 4 receptor Alpha-MSH/MC4R against damage produced by excessive alcohol consumption BAD BDNF IL1B PMC11387119__F3 Inflammasome sensors have diverse roles in tumorigenesis NLRC4 STAT3 NLRP6 NLRP3 MUC2 AIM2 PMC6988351__F8 Inflammasome pathway CRP HEL-S-92n IL1B PMC9301571__F2 Application of Small Molecules in the Central Nervous System Direct Neuronal Reprogramming SAG SHH MTOR PMC4215754__F3 KEGG B cell signaling pathway tuned in CD19 B cells and CD4 T cells SYK CD79A RAF1 SOS1 CD72 CARD11 AKT3 GSK3B CD22 CR2 PRKCB BTK BCL10 PLCG2 CHUK MAPK1 VAV3 BLNK CD19 RAC1 FOS HRAS NFKB1 LYN GRB2 PMC4215754__F2 Visualization of KEGG B Cell Receptor Signaling Pathway after parsing and automatic correction SYK CD81 RAF1 VAV3 CD72 CARD11 AKT3 GSK3B CD22 CR2 BLNK CD19 FOS HRAS BTK BCL10 NFKB1 IKBKB NFKBIA CHUK LYN GRB2 FITM1 PMC8670018__F1 T cell-associated tissues and T cell activation by RANKL-RANK-OPG CD40 LTA LTBR AIRE TRAF6 PMC3584666__F1 Toll-like receptor (TLR) signaling pathway TBK1 MAL TLR9 IRAK1 TLR5 IRF3 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR4 TLR8 TLR7 PMC4215754__F4 KEGG B cell signaling pathway after tissue specific and PPI-based tuning in CD19 B cells SYK PIK3CA RAF1 SOS1 CD72 NFATC2 VAV2 COPE CARD11 CD22 BLNK KRAS HRAS BCL10 NFKB1 SOS2 IKBKB NFKBIA CHUK GRB2 NFKBIB PMC8474727__F6 ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cells ATM HEL-S-87p PLK1 PMC9339679__F3 Ubiquitin specific proteases in the immune microenvironment of prostate cancer: A new direction USP44 CD44 USP22 EZH2 CTNNB1 PMC3366009__F8 T cell signaling pathway used by A2 and A9 ZAP70 IFNG SYK GATA3 PMC11995686__F3 NFZ signaling pathway diagram STAT3 BCL2 ERG USP21 PMC4622601__F1 Mechanism that result in aberrant Wnt/Beta-catenin signaling in colon cancer APC PTEN KRAS SFRP1 CTNNB1 PMC2943975__F1 TOR signaling never gets old: Aging, longevity and TORC1 activity STRADA RHEB MLST8 EEF2K TSC2 EIF4B TSC1 EEF2 HIF1A MTOR VHL EIF4E PMC8301407__F3 Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway IDO1 KMO IDO2 PMC5928365__F7 Ror2‐dependent noncanonical Wnt signaling SIAH2 ROR2 LRP5 LRP6 CTNNB1 PMC3287362__F1 The anatomic and molecular mechanisms of sepsis-mediated sympathoexcitation and ghrelin's anti-inflammatory effect via sympathoinhibition NTS TLR4 ARC PMC8408949__F1 Biology of bone morphogenetic protein signaling pathway in cerebrovascular system TF SMAD1 DKFZp781O1323 SMAD4 PMC4822108__F3 Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer NR1i1 MAX ING3 MYC ENY2 CTNNB1 TRRAP tal-1 BRCA1 E2F4 ACTL6A OFD1 USP22 SCA7 TAF10 KAT2B PMC5674948__F5 Summary of age, BMI, and differential correlation results (a) BMI and age independently increase inflammation in adjacent normal tissue (arrow) FGF7 FAP DCN GATA3 PMC5934344__F1 Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy ROCK1 APC GSK3B ARHA DAAM1 CTNNB1 PMC3039927__F1 Organellar Ca2+ buffering and intracellular Ca2+ dynamics CA4 HRC ORAI1 STIM1 PMC8998661__F2 Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to Bone Disorders LPA DMP1 DKK1 ROCK1 LRP5 MSC LRP6 ARHA CTNNB1 PMC5934344__F3 Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy NOS1AP ROCK1 ARHA DAAM1 PMC5934344__F2 Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy ARHA DAAM1 PMC3874981__F5 NELL-1 signaling pathway NELL1 APC LRP5 SMO LEF1 CTNNB1 PMC3874981__F4 Schematic of Hedgehog signaling pathway SMO GLI3 PMC5297831__F2 The mTOR signaling pathway RHEB RPS6 TSC2 TSC1 PTEN DEPTOR PMC4614341__F1 Schematic of signaling pathways involving the DNA damage response (DDR) pathway in apical and basal cells in the developing neuroepithelium ATR ATM MDM2 PMC7249467__F5 Alterations in Plasma microRNA and Protein Levels in War Veterans with Chronic Mild Traumatic Brain Injury HRAS BAD ARHA GRB2 KRAS PMC7046546__F3 Signaling due to A IFNG APELA MIP PMC8607366__F3 Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury APC NOTUM GSK3B LRP5 LRP6 WIF1 CTNNB1 PMC4657327__F2 FA/BRCA pathway and crosstalk between FA and other DNA repair pathways ATR RAD50 RMI2 MRE11A ATM RMI1 PMC8607366__F2 Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury LATS1 NRG1 LATS2 PMC3874981__F3 Beta-catenin dependent and independent Wnt signaling pathways APC ROR2 LRP5 RHO LEF1 CTNNB1 PMC4391727__F5 Differentially expressed genes related to BMP signalling at day 0 to 3 of arthritis in comparison to non-induced controls BMPR2 EMP2 BMP3 FST SMAD2 BMP4 SMAD4 BMP7 RUNX2 PMC7263055__F2 Establishment of type 2 inflammation in ECRS IL25 TSLP CCL11 IL33 SPINK5 PMC7335243__F3 Possible viral entry and replication mechanism of SARS-CoV-2 ACE2 PMC9231053__F5A Estimation of Carbon Metabolism in Saccharomyces cerevisiae Acclimatized to Glycerol Assimilation with Quantitative PCR GPT PMC8435728__F4 RNA Sequencing for Personalized Treatment of Metastatic Leiomyosarcoma: Case Report FLT3 BAD EGFR AKT3 CYCS BRAF MTOR MYC SKP2 MAPK3 CBLC NRAS MDM2 CASP9 PDGFA CRKL KIT DVL2 KRAS FOS KITLG ARAF HRAS CRK SOS2 NFKBIA BCL2 GRB2 PMC3827358__F8 Lipopolysaccharide Induces Degradation of Connexin43 in Rat Astrocytes via the Ubiquitin-Proteasome Proteolytic Pathway CAV3 NEDD4 TLR4 PMC7567113__F8 BNip1-mediated apoptosis in photoreceptors BAX SEC22B USE1 STX18 KIF3B BNIP1 BCL2 PMC4404867__F1 Coagulation, anticoagulation and fibrinolysis maintain a delicate physiological balance between bleeding and thrombosis TF TFPI PLG VTN PMC3767435__F2 Interactions between TLR7 and TLR9 agonists and receptors regulate innate immune responses by astrocytes and microglia NR2C2 CD80 LTA TIRAP IRAK1 IRAK2 TRAF6 MAPK8 CCL2 IRAK4 PELI1 MYD88 MAPK14 IFNG HSPD1 COX2 CSF2 CASP8 PGLYRP1 IRF3 IRF7 TNF CXCL10 NFKBIL1 UBE2V1 HEL-S-71 LY86 TRADD TNFAIP3 MAPK8IP3 NFRKB TNFRSF1A MAP3K14 CSF3 IL1R1 BTK LY96 RIPK2 MAP2K4 TICAM1 CHUK MUC13 HMGB1 JUN TICAM2 CD14 NR1C1 MAP3K7IP1 NFKB1 IKBKB RELA NFKBIA IFNB1 NFKBIB FADD PMC9031072__F2 Erythropoietin as a Neuroprotective Drug for Newborn Infants: Ten Years after the First Use EPOR EPO PMC2838200__F3 Proposed scheme for how macrophage-based nanoparticle drug delivery could affect disease outcomes in neurodegenerative disorders NGF GDNF BDNF PMC4452916__F3 The effects of hrHPV on NFKB signaling CD40 TRADD MAVS IFRD1 EGFR RELB TLR9 TLR5 TRAF3 TRAF6 HEL-117 HDAC3 HDAC1 SHARPIN TLR1 TLR3 TLR4 RELA TRAF5 RIPK1 TLR7 TRAF2 FADD PMC9214686__F2 Signalling pathways downstream of cGAS and of endosomal TLRs TBK1 CGAS TLR3 TLR9 TLR8 IRF3 IRF7 TLR7 IRAK4 MYD88 PMC4762514__F4 Metabolic pathway alterations in PCT OGT HK2 NAMPT NAGK GNPNAT1 PNP HEL-S-182mP TMLHE PGM3 ALDH7A1 CHDH AASDH MTR AASS PMC6011013__F5 Integration of mRNA data and CNAs profiles: BMD+DAD-screening network using Coxnet (top) and ADMMnet (bottom) methods with mRNA expression data and the integration of mRNA data and CNAs profiles OR8S1 IFNK OR10AD1 GLP1R IFNA6 FGFR4 GLRA1 OR6Y1 OR5I1 PMC6011013__F4 mRNA expression data: BMD+DAD-screening network using Coxnet (left) and ADMMnet (right) methods with mRNA expression data and the integration of mRNA data and CNAs profiles ALDH3B2 GLP1R OR2B11 PKMYT1 RRM2 FGFR4 ERBB2 BCL2 TACR1 MYL12B OR1C1 OR5I1 PMC3558460__F1 Signal activation of human somatostatin receptor subtype-2 by membrane-displayed somatostatin SSTR2 HEL-S-5 PMC4856717__F1 Main pathways involved in CD40-TRAF signaling CD40 CD80 CCL2 TNF PMC3009535__F3 Functional module of the CXC chemokine pathway uniquely identified by NeMo PLA2G10 PLA2G6 GNA11 PRKCA PLA2G3 PLA2G5 PLA2G2D PLA2G2F PLA2G2E GNA13 PLA2G2A PMC8124173__F3 Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update BAX MFN2 BCL2 MDM2 BDNF APAF1 PMC6462412__F2 DNA repair pathways—a toolkit for viral replication FANCD2 ATR RAD51 DNA2 BRCA1 BRCA2 GEN1 PALB2 BLM SLX4 EME1 PMC2660752__F6 Metabolic origin of glyoxylate in M HEL-S-62p C2 PMC5440111__F2 Enhanced anabolic PI3K/Akt pathway in a cancer cell ACLY BAD MTOR MYC PMC4912847__F1 Exosomes in liver pathology CD81 CD82 DROSHA CD63 PMC3294420__F3 Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links STAT3 CD2 CD36 EBP ELF2 G0S2 CS IL6 XBP1 IRS1 LPA PNPLA3 FOXO1 DGAT2 TLR4 PMC3294420__F2 Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links LPL LPA CD36 TLR4 CS IRS1 PMC8301965__F9 Hair Growth Stimulation Effect of Centipeda minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways IGF1 APC LRP5 LRP6 CTNNB1 PMC11937447__F2 Functions and mechanisms of lncRNAs in endoderm differentiation SOX17 FZD5 EN2 HOXA1 CTCF EN1 GSC FOXA2 GATA6 IGF2BP2 PMC10865172__F3 Roles and mechanisms of ESM1 in tumor angiogenesis VWF STAT3 EGF MAP3K7IP1 EGFR DLL4 TAB3 ESM1 MTOR PMC4467862__F3 Crosstalk between erythropoiesis and iron metabolism involving TGFB family member GDF11 ERFE BMP6 GDF11 SMAD4 PMC4247524__F2 Long-patch BER pathway LIG1 FEN1 PCNA PMC4711368__F4 Signaling pathways of cytokines in GnRH neurons CNTF LIF IL1B PMC4247524__F1 Short-patch BER pathway PNKP PMC9214686__F4 Transport and metabolism of cGAMP SLC46A2 CGAS CD14 ENPP1 PMC3737373__F9 RNAi Mediated Tiam1 Gene Knockdown Inhibits Invasion of Retinoblastoma CD44 EGF TIAM1 MAP1B PMC3258560__F1 Signal transduction by TGFB family members SMAD1 DKFZp781O1323 SMAD2 SMAD6 RHO PMC8246814__F2 Endothelial cell and T‐cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation CIC CD36 PMC11121563__F1 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review CCL22 CCL18 COL1A1 CEMIP PIK3AP1 PTEN HDAC7 MTOR BDNF CYLD PMC3303613__F1 Signaling pathways in the pathogenesis of nasopharyngeal carcinoma (NPC) EGFR APC TERT PTEN MYC FOS CDK4 CTNNB1 PMC9554952__F4 Review of Herbal Medicine-Based Phytochemical of Garcinia as Molecular Therapy for Breast Cancer RHEB STAT3 TSC2 TSC1 EGFR PTEN PMC11121563__F3 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review PTEN MTOR PMC5776718__F1 Overview of the L-lysine biosynthetic pathway in Synechococcus sp MAL CIT PMC9554952__F3 Review of Herbal Medicine-Based Phytochemical of Garcinia as Molecular Therapy for Breast Cancer BAX FAS TRADD MCL1 TNF FADD PMC11121563__F2 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review EMP1 FOXO3A PTEN PMC3159580__F3 Not(ch) just development: Notch signalling in the adult brain STAT3 SOX2 NUMB HIF1A MTOR RBPJ CTNNB1 F3 SHH CDK2 EGFL7 BDNF CCND1 DNER PMC1884140__F11 Schematic representation of the differentially expressed genes and how they are induced upon injection by (A) pristane or (B) phytol IFNG MMP12 IFIT3 OASL MX2 IRF7 OAS1 PMC11121563__F4 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review BCL9 HEL-S-94n PMC5723907__F1 General induction and receptor signaling pathways of type I and type III IFNs STAT1 MAVS IFNAR2 IRF9 IFNAR1 IRF1 IRF3 IRF7 JAK1 TYK2 PMC4141691__F5 Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease EIF4B RICTOR RPS6KB2 PTEN MTOR GHR PMC5376156__F1 Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/Beta-catenin Signaling Pathway SOX9 CCND1 CTNNB1 PMC6136541__F4 E2 on bovine mammary epithelial cells during Staphylococcus aureus infection S100A7 IL16 IL1B PMC3775402__F1 Alternative splicing regulation of the Ras-MAPK pathway EIF4E PMC5397778__F3 Helicobacter pylori-induced chronic inflammatory and neoplastic diseases IFNG CDX2 MSC SHH PMC5397778__F2 Simplified schematic depiction of the canonical hedgehog (HH) signal transduction pathway within the primary cilium GPR161 HHIP BOC SUFU GSK3B SMO GAS1 GLI3 PMC7154114__F5 Systems biology is an interdisciplinary field that involves computational and mathematical investigations for modeling a complex biological mechanism FOXD1 FUT1 EGFR NMU IL6 PLK1 FOS VHL FOXM1 GTSE1 CDKN1C MDM2 CCND1 PMC3775402__F2 Alternative splicing regulation of the PI3K-mTOR pathway RHEB TSC2 PTEN MTOR EIF4E PMC3759017__F1 Key mutational and therapeutic targets in melanoma AKT3 BRAF NRAS KIT PTEN ME1 PMC4918247__F1 HGF/c-Met signaling cascades.Notes: Upon binding of HGF to its receptor c-Met, c-Met is dimerized and activated by phosphorylation of Tyr 1234 and Tyr 1235 residues CDC42 STAT3 HGF RAF1 GRB2 MTOR RAC1 PMC6163197__F2 Main metabolic pathways triggered by chronic brain hypoperfusion (CBH) RHEB TG TSC2 BNIP3 BCL2 ATM MTOR PMC7880438__F8 PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation NBR1 TBK1 MAVS RNF5 IRF3 PMC6936254__F2 PPI network of DEGs IL20RB MDK SMAD1 CHAC1 NCF2 CD177 GSDMB PLA2G4C PDE4B NTNG2 NOX4 ASAH2 GIMAP4 HLA-DRA TUBB2A APLN JAG2 KDR EEF1A2 PMEL JUP CACNA1A MCAM CSF2 MMP10 MMRN1 FAM131B RELN LIPG CD34 ENAM KCNK3 ANGPT4 GPR17 DISP2 TFPI PTGIS CYP2U1 FGA HLA-B ASNS TXLNB KCND1 DHRS3 PMC9653480__F6 Obesity downregulates lipid metabolism genes in first trimester placenta LPL TG ACOX1 NR1C1 PMC6198802__F3 Key cellular and molecular pathways regulating blood-brain barrier integrity TGFBR2 EPHB2 ANGPT1 PTCH1 SHH SMAD4 VEGFA PMC6707807__F1 Enriched immunological pathway and genes ZAP70 EHD3 WASL MRC2 TAP1 AGAP1 FGFR2 NCR2 HLA-E FYN HLA-F HLA-G HLA-B HLA-C TNFSF10 SHC3 PMC8326125__F8 TNFA augments CXCL10/CXCR3 axis activity to induce Epithelial-Mesenchymal Transition in colon cancer cell CXCR3 ARHA CXCL10 PMC8201612__F4 Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand RHEB MLST8 TSC2 TSC1 PPM1K HEL-S-62p MTOR PMC6027909__F1 Primary mechanisms by which AIBP protects against macrophage inflammatory response STAT3 ABCA1 IL1B MYD88 PMC8201612__F3 Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand RHEB TSC2 TSC1 F2 ELF2 MTOR DEPTOR EIF4E PMC8201612__F2 Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand RHEB MLST8 TSC2 RICTOR TSC1 IGF1 GSK3B ELF2 MTOR DEPTOR IRS1 PMC2394714__F10 TGFB1-induced PAI-1 expression in VSMC EGFR SMAD2 SMAD4 ARHA PMC5487013__F7 Data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells BAMBI SOST NOTUM LRP5 CER1 LRP6 PMC6611711__F1 Lipid biosynthesis in cancer cells ACLY ACSS2 TG FAS SLC25A11 SCD MTOR PMC3978476__F4 Major metabolites and genes contributing to the choline metabolism pathway PNPLA7 PLCD3 PLA2G10 GDPD5 PNPLA6 PLA2G6 SLC22A2 PLA2G2E CHKA CHKB PLD3 PMC5352242__F1 Schematic illustration of the intracellular trafficking dynamics of mitochondria-targeting nanoparticles PINK1 FIS1 TBC1D15 PMC3560328__F2 DNA interstrand crosslink repair and cancer ATR RMI2 BRCA2 FANCM FAN1 FANCL FANCA BLM FANCC FANCB FANCE FANCG FANCD2 FANCF BRCA1 RMI1 PMC9555684__F1 Metabolic recycling of storage lipids promotes squalene biosynthesis in yeast IPP HEL-S-5 ERG PMC3560328__F4 DNA interstrand crosslink repair and cancer FAN1 EME1 PMC9629834__SF4_2 Protein network and Netrin-DCC pathway analysis CDC42 STXBP1 GNAO1 NFATC2 SLC6A1 PRKCB CAMK2A PLCG1 AP2A1 AP2A2 SRC ABLIM1 TSPAN7 AP2S1 DCC NTN1 CDKL5 ROCK2 NCK1 PTPN11 ARHA RAC1 PURA AP2M1 SYNGAP1 CDK15 CAMK2D SNAP25 CAMK2G PMC3560328__F3 DNA interstrand crosslink repair and cancer ERCC1 FANCD2 RAD51C REV1 RAD51 BRCA1 BRCA2 FANCM FAN1 BLM EME1 PMC5293538__F1 Abbreviated polyamine synthesis pathway AGMAT SMS SRM PMC2630373__F1 Regulation of G1/S transition by growth factor (insulin and IGF-I) signaling in Beta-cells FOXM1 PDX1 CCND2 SMAD2 SMAD4 MDM2 CCND1 IRS1 PMC4380073__F2 Simplistic overview of the top two mutation-enriched transduction signaling pathways in ATC as according to the Genomatix Pathway System HRAS PIK3CA RAF1 BRAF MAPK10 IGF1R NF2 MTOR KRAS RAC1 PMC8460515__F2 Pharmacological properties of baicalin on liver diseases: a narrative review BAX FAS NLRP3 GCLM GCLC NR2A2 SAMD3 SIRT1 PMC8615556__F1 miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma ATF3 STAT1 IFNGR2 IFNGR1 IGF1 USP22 CCL4 PTEN B2M IGF1R JAK1 CTNNB1 PMC7706582__F4 Epigenetic Mechanisms in Leukemias and Lymphomas CHD2 FLT3 STAT3 CD79B CD79A MEF2B CARD11 TRAF3 MYC MYD88 RB1 CDKN2A BCL10 BCR PAX5 MAF NOTCH1 SMARCA4 LPL EZH2 B2M PREB NOTCH2 TNFSF14 BCL2 GNA13 KLF2 SF3B1 FAS TNFAIP3 HEL-S-62p TNLG8A BRAF PTEN CD83 MLL2 NFKBIE ATM TBL1XR1 CCND1 CCND3 KMT2C IKZF1 SGK1 PTPN11 IRF4 ARHA ID3 C2 NFKBIA CREBBP FGFR3 BIRC2 TRAF2 BCL6 PMC7730528__F10 Graphical illustration of prolidase-dependent EGFR, B1-integrin receptor, TGFB1, and IGF-1R-downstream signaling SOST EGFR IGF1R GRB2 MTOR SHE SRC PMC7412373__F4 Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways PTEN MTOR CTNNB1 MYD88 PMC7412373__F3 Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways DUSP5 PTPN22 FAS CD69 PTEN NLK MTOR E2F5 ATG5 PMC4352617__F3 Proposed mechanism for transcription-dependent p73-induced apoptosis BAX CASP3 GRAMD4 FADD PMC6611711__F6 Phospholipid and TG synthesis pathway LPA TG PGP SMS FASN PEMT PC PMC11013731__F6 Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NFKB/MAPK/JNK Signaling Pathway in Lipopolysaccharide-Treated C57BL/6 Mice TLR4 UNK PMC5487013__F8 Data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells SOX17 FZD5 DKK4 SNAI2 GPC4 NFATC2 TFAP2A MYC GATA3 CXXC4 FZD4 CAMK2D DKK1 ETV4 CER1 WNT3 NR5A2 LEF1 WIF1 PMC7412373__F1 Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways SOX6 EBP TLR4 APC MAF PTEN CTNNB1 PMC7254050__F5 Proteins co-associated with hyaluronidase (HYAL)-2 have roles in actin organization and contraction function HEL114 ACTG1 ACTRT1 POTEF ARHA HYAL2 PMC5573869__F3 Regulation of the G1/S cell cycle checkpoint pathway by Pontin/Reptin at multiple levels CDK6 ECD GSK3B CDK2 MYC CCND1 CDK4 CTNNB1 PMC7461995__F1 Pseudomonas aeruginosa Can Degrade Interferon λ, Thereby Repressing the Antiviral Response of Bronchial Epithelial Cells STAT2 IRF9 IRF1 IRF3 MX1 IRF7 JAK1 OAS1 TYK2 PMC7465013__F5 Gene networks analysis of quercetin–resveratrol modulated genes suggest IGF1 and BCL2 as key signaling nodes associated with anti-PCa effects TMPRSS2 CAV2 MSX1 AIP IGFBP7 TUBB PMC5573869__F6 Regulation of DNA damage response and repair by Pontin/Reptin FANCD2 ATR BRCA1 INO80 ATM YY1 PMC5573869__F5 Regulation of transcription factors by Pontin/Reptin AGR2 HINT1 ETS2 APPL1 TERT HIF1A MYC APPL2 CCND1 RPAP3 IL1B CTNNB1 PMC8509131__F1 NLRP3 Inflammasome: Relevance in Solid Organ Transplantation SYK HMGB1 NLRP3 TXNIP IRF3 TNF FADD PMC5573869__F7 Role of Pontin/Reptin in the EMT pathway CDH2 STAT3 EGF EGFR VTN HIF1A ZEB2 MTOR CTNNB1 PMC6299112__F4 Proposed roles for miR-137 at the glutamatergic synapse CPLX1 NRG1 RICTOR MIB1 GSK3B PTEN MTOR BDNF SYT1 PMC6299112__F3 Neuronal signaling events that influence miRNA biogenesis, activity, and degradation MOV10 AGO2 BDNF DROSHA PMC6299112__F2 Overview of the canonical miRNA pathway, from synthesis to degradation MOV10 DGCR8 DROSHA PMC9134343__F3 Controversial Role of IL-33 in Lung Cancer IL33 FOXP3 MYD88 PMC11599537__F3 TLN1 in cancers CDK5 F2 F3 TLN1 PMC8748693__F3 Metabolic routes contributing to ferroptosis SLC3A2 IPP STEAP3 GPX4 FACL4 SLC7A11 SFXN1 DHODH PMC10854112__F10 Schematic showing the preliminary mechanism of Gnao1 in SCs regulating SC differentiation and myelination POU3F1 GNAO1 PRKAA2 POU3F2 EGR2 OLIG1 PMC8630058__F5 Metabolic pathway linking methane oxidation to selenate reduction by bacterial consortia AGXT HBD CS GCK MMD PMC6579773__F2 Alternative pathway of the complement system C6 HEL-S-62p PMC7284929__F7 Ingenuity Pathway Analysis (IPA) and western blotting validation of common differentially expressed proteins CA4 EHHADH LETM1 TGFBI ETFB IDH3B CD36 HEL111 AFM NDUFA13 ACADM ETFA EVL UQCRHL AK1 PXDN GPLD1 SAA1 ABCB6 NDUFC2 OPA1 SERPINA1 MPC2 SLC4A4 UQCRC1 ACACB PGAM2 GPD2 RMND1 SCARB1 FGL1 HEL-S-162eP PON1 ZNF183 PMC6923491__F2 Bayesian theorem-optimized possible optimal acting pathway of axonal regeneration CRK NGF FRS2 OCA2 GSK3B PIR ARHA GRB2 BDNF PMC6923491__F1 Pathway diagram of axon regeneration regulatory network CRK NGF FRS2 OCA2 GSK3B ARHA GRB2 BDNF PMC6185869__F1 Simplified PI3K Signaling Cascade and Known Clinical Disorders Caused by Genetic Pathway Activation BAD AKT3 PTEN PMC8036978__F1 Simplified extrinsic signaling pathway from TNF-R1, Fas, DR4, and DR5 FAS TRADD TRAF2 FADD PMC7730007__F8 Mapping the S1P-S1PR1signaling pathway in differentiated SGBS and 3T3-L1 adipocytes MAPK4 SPHK2 AKT3 PLCB1 MAPK7 PLCB2 SMPD2 PMC4342569__F8 The multi-targeted tyrosine kinase inhibitor vandetanib plays a bifunctional role in non-small cell lung cancer cells RHO RET UNK PMC4484476__F7 Inhibition of Beta-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear Beta-Catenin/TCF-1 complex: Critical role of STAT-3 STAT3 APC GSK3B CTNNB1 PMC2718747__F10 A model of EGF/EGFR-induced inhibition of a Luminal-A phenotype in MCF-7 cells EGF EGFR GATA3 PMC7513516__F1 Domain structure and signaling pathway of STAT3 SOCS1 STAT3 CD80 ME2 MCL1 MMP2 HIF1A CXCL10 SRC MYC TNF TWIST1 PMC7713510__F6 SRC-1 and SRC-2 serve critical roles in developmental regulation of 11Beta-HSD1 expression by glucocorticoids and cytokines GC TNF IL1B PMC138687__F1 The TGFB signaling pathway, showing the activation cascade and points of inhibition (??) BAMBI EGF SMAD6 PMC149906__F5 A model to explain the effects of varying Fgf8 dosage on cell survival EMX2 BMP4 SPRY1 FGF8 FOXG1 PMC3899875__F4 MiR-148b in the mTOR signalling pathway RHEB TSC2 EIF4B RICTOR TSC1 BRAF PTEN HIF1A MTOR IRS1 EIF4E PMC3899875__F5 MiR-15a in the AD pathway LPL IDE CASP9 BAD CASP8 CASP12 APOE GSK3B SNCA TNF CASP3 APP FADD PMC9546099__F5 Absorption, metabolism and excretion of opicapone in human healthy volunteers C2 CTGF PMC8843878__F3 Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways ACHE PPARG EGF PTGER3 NPEPPS SELE PGR EGFR GSK3B ACACA VEGFA TNF MYC FOS POR PSMD3 HEL-S-130P NR3A2 RELA PRKCA MMP3 AHR CYP3A4 PMC3517193__F1 Graphic illustration of the perturbation of the insulin signal transduction pathways by cellular stressors ELF4 BAD CBL IRS4 PTEN GRB2 MTOR IRS1 PMC6386093__F5 Metabolic profiling of intracellular metabolites involved in branched-chain amino acid catabolism HEL-S-62p ACADS PTEN PMC3821079__F1 Schematic representation and overview of PI3K/AKT/mTOR/PTEN signaling TSC2 TSC1 PTEN MTOR CTNNB1 PMC8368180__F1 Inflammation and the TME in oesophageal carcinogenesis IFNG IL10 IL6 IL1B PMC11648920__F3 Schematic diagram represents the DEGs expression enriched in SA, JA and ET signalling pathway EBF2 PMC3821079__F3 Several inhibitors linked to the PI3K/AKT/mTOR/PTEN signaling pathway are shown TSC2 TSC1 PTEN MTOR CTNNB1 PMC11648920__F5 Various signalling pathways and resistance mechanisms in wheat in response to Puccinia infection TF ERF CBL PMC9235346__F3 Integrating proteomic and clinical data to discriminate major psychiatric disorders: Applications for major depressive disorder, bipolar disorder, and schizophrenia TF NPC2 SERPIND1 TH MBL2 GPR37 TFPI CTSS CP PMC4091179__F10 Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells FKBP1A MTOR TIA1 PMC4428629__F1 Structure of an NDR/LATS Kinase–Mob Complex Reveals a Novel Kinase–Coactivator System and Substrate Docking Mechanism MOB2 KIT GCK ACE2 PMC4465887__F1 Advances in recent patent and clinical trial drug development for Alzheimer’s disease ACHE APP PMC3773820__F8 Role of Nor-1 in incretin-induced insulin expression and secretion and hypothetical localization of the TCF7L2 and NR4A3 SNP effects TCF7L2 NR4A3 INS PMC7385902__F3 Correlation plots for genes (absolute Pearson correlation > 0.4) that contributed to the enrichment of MAPK38 pathway in ER negative tumor and phosphocholine synthesis in ER negative normal-adjacent samples MAPKAPK2 ATF2 HMGN1 CHKA SLC44A2 LPIN3 MEF2C CHKB PMC6457711__F2 Regulatory mechanism of calcium on HIF1A induction TRPM2 STIM1 TRPC1 MCU MTOR TRPC6 TRPM8 PMC11591698__F1 General Hippo signaling pathway PATJ RHO TEAD4 CTNNB1 LATS1 LPA CD44 LATS2 TEAD2 TEAD3 AMOT SCRIB NF2 PMC6773241__F8 Graphical abstract showing the main findings of this study HRAS RAF1 E2F4 EGFR PMC11591698__F2 IPA ingenuity pathway analysis: IPA is a software application used for the analysis and interpretation of YAP’s complex biological interactions in cancer development FAT4 CRB1 SCRIB PMC11591698__F4 Hippo pathway TF SCRIB NF2 PMC9181096__F11 Ginsenoside Rc Promotes Bone Formation in Ovariectomy-Induced Osteoporosis In Vivo and Osteogenic Differentiation In Vitro APC GSK3B RUNX2 CTNNB1 PMC9224458__F2 MicroRNAs in Signaling Pathways Associated with the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Focus on Epithelial-Mesenchymal Transition SMAD2 APC CTNNB1 TGFBR1 PMC5661129__F2 Crosstalk between cancer and cancer stem cell-related pathways EGF COBL FOXD3 EGFR PROC PMC4914454__F5 “The Expanding GRK Interactome: Implications in Cardiovascular Disease and Potential for Therapeutic Development” CA3 HDAC5 PMC4717619__F1 Schematic of tumor cell interactions in the brain ROR1 CXCL12 EGFR JAG2 PTEN IL6 CXCR4 NOTCH1 PMC11705629__F5 AMPK signaling pathway in macrophages and fibroblasts cross-talk TSC2 CSF1 SMAD2 SMAD4 MTOR SMURF2 CCL2 PMC5241746__F10 Working model ERBB4 EGFR NOTCH1 PMC6033069__F4 The anti-inflammatory effects of MPQP on the LPS-induced inflammatory pathway TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC8268872__F1 Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling GRB2 MTOR IRS1 PMC6430496__F2 Underlying molecular mechanisms of ZFAS1 in multiple human cancers MMP16 KLF2 MMP14 AGO2 NKD2 EZH2 PMC11350703__F18 PDK1-mediated TGFB/Smad signaling pathway by hypoxia in yellow cattle and yak PASMCs SMAD2 SPHK1 PMC8306115__F3 Ciliary Signalling and Mechanotransduction in the Pathophysiology of Craniosynostosis IHH CS IFT140 FLNA NEK1 CEP57 IFT43 EVC TMEM216 MCPH1 CDC45 WDR35 SMO RAB23 GLI3 PMC8908322__F1 What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us? TF EGFR PMC10816037__F1 Different signaling pathways affected by the probiotic strains with anti-obesity or anti-diabetic properties in C ACOX1 NR1C1 PMC7563518__F1 Metabolic pathways of l-tryptophan (a) and l-arginine (b) NOS2 TDO2 ASL SMS IDO1 IDO2 PMC6764206__F4 Biosynthetic pathway of plasmalogens and diacyl phospholipids PGP CDS2 C1S PEMT PC CEPT1 PCYT2 PISD PMC5439240__F2 Paracellular intestinal barrier in health and inflammation HEL-S-79 CLDN5 CLDN2 PMC6070911__F1 Biosynthetic pathway of ansamitocin P-3 GAL ACD PMC5963017__F8 Pridopidine enhances cAMP/PKA and TrkB pathway genes in the YAC128 striatum RGS21 HEL70 GPR31 BDNF DUSP11 FOS PMC9306014__F1 CDK4 stabilization and canonical function in the cell cycle CDC37 MYC CDK4 VHL PMC11274597__F1 Outline of the HH signaling pathway [16] KIF7 SUFU SMO PMC4440459__F16 Summary of Ingenuity Pathway Analysis (IPA) TPM1 STAT1 ALDH18A1 FLNB AK1 DPP4 CNN2 DAP SMC2 LILRB3 S100P SMC4 PMC8908322__F3 What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us? GATA2 EGF NRG1 ATG12 EGFR NGFR HSF1 GC BTC PICALM PMC8908322__F2 What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us? SOX9 EGFR PMC3588201__F1 Gene regulatory networks for cDC and pDC development FLT3 STAT3 BATF ID2 PDC RELB BATF3 IRF4 GFI1 PMC6306406__F1 Schematic elucidation of IL-33 IL33 IRAK1 TRAF6 IRAK4 MYD88 PMC7419519__F3 KEGG pathway mapping of CHO global spectral library UFD1L SVIP STAG2 ATR CDC20 PCNA ORC6 CDC6 STAG1 SMC3 SMAD2 GSK3B SMAD4 ORC1L MYT1 SKP2 PLK1 SEC62 CDK6 CDK7 E2F4 ATM ATF4 EIF2A MDM2 CDK4 CDC2 DBF4 BAX OS9 CASP12 APC ORC3 ORC2 RBX1 SEC63 CDC45 CDK2 BCL2 WFS1 PMC10177097__F9 Effects induced by Exe plus CBD in MCF-7aro cells TFF1 AREG PMC6126011__F2 Leptin intracellular signaling pathway STAT3 TSC2 TSC1 POMC SOCS3 GRB2 IRS1 PMC3442876__F2 Autophagy in immunity NBR1 HMGB1 IRGM SQSTM1 CALCOCO2 IL1B PMC4571863__F11 Model showing that KLF17 suppresses cancer metastasis via a p53-dependent pathway (a) and showing that a novel positive feedback loop exists between p53 and KLF17 (b) HEL113 KLF17 PMC3234240__F2 Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays COX7A1 MYH6 SNCA PDK3 PDK2 TNF IL5 COXFA4 NDUFB10 CISD1 CKMT2 APP ACTG2 CREB1 PMC4001935__F7 FoxD3 regulates cranial neural crest EMT via downregulation of Tetraspanin18 independent of its functions during neural crest formation FOXD3 TSPAN18 SOX10 PMC8375236__F3 ATM at the crossroads of reactive oxygen species and autophagy TSC2 PEX5 ATM MTOR ADH5 PMC8375236__F2 ATM at the crossroads of reactive oxygen species and autophagy PEX5 ATM ADH5 PMC5738336__F9 KEGG (Kanehisa & Goto, 2000) PI3K-Akt signaling pathway (map04151) is enriched for genes differentially expressed between lesion and healthy lung tissue in cattle challenged with BRDC pathogens SYK EIF4B BAD EBP RBL2 PTEN CD19 MTOR ME1 RAC1 TSC2 BCR RXRA MDM2 PMC6312990__F4 Signalling pathways related to PRL-3/EGFR/c-myc genes in cancer cells EGFR CSK PTEN SRC PMC11674862__F4 ADAM17 activation triggers AREG-dependent pathways STAT1 ADAM17 EGFR AREG PMC6209233__F8 Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential TH MAK MAL PMC8181544__F2 Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications? HEL-S-62p ACE2 PMC11674862__F2 Interactions of ADAM17 with IL-6, IL-1B, and IL-15 ADAM17 IL15RA IL1B PMC4703318__F1 Molecular Pathways: Turning Proteasomal Protein Degradation into a Unique Treatment Approach FBXW7 FAF1 HIF1A CTNNB1 PMC6209233__F9 Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential LPL UBC AQP7 UCP1 HEL-S-28 PLTP PMC8425587__F1 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) HSF1 TCF4 KRAS CTNNB1 PMC8425587__F4 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) KLF4 SQSTM1 TRAF6 TNF PMC8425587__F6 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) NBR1 EGF EGFR HIF1A TRAF6 VHL PMC8425587__F5 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) ECSIT KEAP1 SQSTM1 MTOR TRAF6 TNF PMC9345804__F1 Molecular Alterations in Malignant Pleural Mesothelioma: A Hope for Effective Treatment by Targeting YAP CD44 POLL EGFR CD5 MTOR PMC3494151__F4 Impact of SIRT1 knockout on selected cellular pathways and protein complexes SNRPD2 RBMX DKFZp434N041 ING5 PRPF8 SNRPD3 NCBP1 PRPF6 MEAF6 SMNDC1 HNRNPK ING4 PUF60 SNRNP200 SF3A1 KAT7 LIG1 PRPF31 RUVBL1 CHERP RBM17 ZMAT2 SIRT1 TRA2B CDK9 SNRPA1 BRD4 SF3B1 PCNA ING3 SNRPC PRPF40A TCERG1 TRRAP DDX42 EP400 RBM25 YEATS4 U2AF2 DHX15 PRPF38B VPS72 EPC1 SF3B2 PRPF3 DDX5 HNRPA3 SNRPA FEN1 PRPF4 PCBP1 PARP1 HDAC1 DMAP1 PHF5A RUVBL2 PMC5801050__F3 Cullin 3-based ubiquitin ligases as master regulators of mammalian cell differentiation SPOP CTNNB1 PMC10937391__F9 Hypotheses on the mechanistical/functional involvement of each microRNA and its potential mRNA targets on OPC differentiation RAB10 JUN BNIP3 PTEN ARHA RAC1 RHEB FYN ELMO1 MYRF PAK1 MBP RRAS2 CCND1 PMC9162454__F2 Pyroptosis is executed by the gasdermin pore-forming family of proteins BAX FAS GSDMD GSDMC GSDMB AIM2 DFNA5 GSDMA TNF PMC3874794__F2 An outline of the GPI and GPI-anchored protein biosynthetic pathway HEL-S-5 PIGM PIGU PMC4601220__F1 RNAi pathways in insects RAN AGO1 AGO2 DROSHA PMC3018616__F1 TGFB superfamily signaling pathway SMAD1 DKFZp781O1323 SMAD2 PLG SMAD6 SMAD4 PMC4539294__F2 Schematic of the itch spinal cord circuit.The initial stages of the itch-circuit in the spinal cord are characterized by the expression of neuropeptides and the post-synaptic expression of their cognate receptors ITCH NPPB SST PMC4743801__F3 The globo-series pathway in human FUT1 FUT2 B3GALT5 PMC9367932__F1 Macrophage Phenotypes in Normal and Diabetic Wound Healing and Therapeutic Interventions CCR6 CCR2 CCL2 TNF CCL20 CD207 PMC8911152__F2 New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females STAT3 BAX TRH TSHR FSHR NR1A2 TRHR PMC8549629__F8 Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro SYK BTK TRIO TIAM1 PAK1 RAC1 PMC9475358__F2 Tumor and Metastasis Initiation by Chemokine Receptors CXCL12 SMO CXCR4 PMC11611719__F7 Schematic model indicates that ozone promotes macrophage efferocytosis and alleviates neuropathic pain ADAM17 SOCS3 MERTK PMC8023146__F1 African Swine Fever Virus MGF-505-7R Negatively Regulates cGAS–STING-Mediated Signaling Pathway TBK1 CGAS ULK1 IRF3 PMC4963810__F1A Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer APC GSK3B LRP5 LRP6 CTNNB1 PMC9330518__SF1 Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy SIRPA CD47 PMC9139855__F2 Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications CYP1A2 PLAT AHR IL6 CYP1A1 PMC8688453__F1 Mitophagy process PHB2 PINK1 BNIP3L FUNDC1 PMC8134040__F7 EphA2–YES1–ANXA2 pathway in GC growth and progression STAT3 YES1 EPHA2 ANXA2 MYC PMC6712457__F3 Linc00152 promotes the proliferation of gastric cancer cells by regulating the PI3K/AKT signaling pathway EGF BAD EGFR PTEN PDK2 MTOR PMC6600655__F1 Agent that activates the cascade in the MAPK pathway, which can lead to TJs opening or assembly MMP7 EGF HGF C2 PMC9688352__F1 Macrophages and Wnts in Tissue Injury and Repair JUN APC ROR2 GSK3B LRP5 LRP6 RYK ARHA CTNNB1 PMC6712457__F1 Linc00152 promotes the proliferation of HCC cells by activating the mTOR signaling pathway EGF BAD EGFR PTEN PDK2 MTOR PMC5793041__F6 Integrative view of DENV-induced metabolic alterations in hepatic cells TG FASN HEL-S-5 PMC2963103__F1 Normal biology of the VHL-HIF axis in the setting of (A) normoxia and (B) hypoxia TGFA EGFR MAPKAPK2 MAPKAPK3 EPO BNIP3 MTOR VHL PMC3299304__F3 Molecular mechanisms of HGF-c-Met-mediated signaling for inhibiting TLR4-mediated NFKB activation in macrophages HGF TLR4 GSK3B PMC6538558__F3 Three example models in the CODA-ML format CASP9 UBC EGFR FGFR1 GSK3B CDK2 MYC CDK4 PMC7479313__F15 Signaling Pathways of E2Fs in Gastric Cancer (TGFB Signaling Pathway) CDX2 RARA ATR HGF POLK MUC2 APC SHH ERBB2 BCL2 TERT PMC7012489__F1 Canonical and non-canonical nuclear factor kappaB pathways CD40 BCL2 BIRC3 PMC5518632__F3 NLRC5/CITA: a key player in cancer immune surveillance TAP1 HLA-A PMC4418510__F1 Canonical TNFR to Nf-kB pathway TRADD RIPK1 TRAF6 CYLD TRAF2 PMC7072652__F2 Failure of major homeostatic mechanisms contributes to senescence onset APP MDM2 MTOR SIRT1 PMC12236747__F3 Indole metabolites induce neuroinflammation through the AHR and NTS pathways VEGFB NTS TGFA IFNAR1 SOCS2 AHR FLT1 BDNF PMC5735681__F1 Different proteins on the Wnt signaling pathway WNT3A APC GSK3B WNT7A CTNNB1 PMC4334449__F1 Pathogenesis of HCC and targets for chemopreventive agents COX2 EGFR CDK2 PTEN MDM2 MTOR MYC PMC4618041__F7 Model depicting Dcp1-mediated translational repression in endotoxin-tolerant cells AGO2 RBM4 TLR4 PMC5735681__F3 Interaction between the Wnt and the Notch signaling pathways WNT3A HES1 HES5 PMC7468867__F9 The regulatory effects of foxtail millet on the progression of colitis-associated colorectal cancer (CRC) STAT3 PCNA AHR FOXP3 PMC5285348__F8 Mutual regulation between miRNAs and the Wnt pathway determine the survival of Mycobacterium tuberculosis (M FZD4 FOXO3A PRDM1 DKK1 APC TNF MYD88 PMC5285348__F7 Nucleotide-binding oligomerization domain 2 (NOD2) and the activation of the Wnt pathway in response to Mycobacterium tuberculosis infection IL16 APC NOD2 LEF1 CTNNB1 LYPD6 PMC5313500__F2 The proposed cellular functions of cellular NLRC5 USP14 MMP7 CSA2 MAVS NLRP3 SMAD2 SMAD4 TRAF6 TRAF2 IL1B CTNNB1 PMC5285348__F9 Beijing Mycobacterium tuberculosis (M SOST APC NOTUM CER1 ARHA LEF1 CTNNB1 PMC7834968__F8 Schematic diagram showing how ASV alleviates silica-induced pulmonary fibrosis by regulating TGFB1/Smads pathway SMAD2 SMAD4 PMC3368918__F1 Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis NR1i1 CYP2R1 CYP27B1 CYP24A1 GC DHCR7 CYP27A1 PMC7201093__F1 Summary of the mechanisms that myocardial protection mediated by melatonin through receptor and non-receptor pathways RYR2 BAX SIRT3 BAD FAS MCL1 MFN2 GSK3B BDNF SIRT1 NOTCH1 RORA PMC5285348__F3 Canonical Wnt signaling pathway APC LEF1 CTNNB1 PMC5285348__F5 Mycobacterium tuberculosis (M TLR4 WNT3 FZD1 TNF CTNNB1 MYD88 PMC7824104__F2 Nrf2 signaling RBX1 KEAP1 MAF AHR SKP1 PMC8656547__F2 Emerging Role of Non-Coding RNAs in Pituitary Gland Tumors and Meningioma TESC MAP3K7IP1 SMAD2 SMAD4 ATF2 TUG1 PMC6436804__F9 Summary of the toxic mechanisms of ZEA on breast cancer cell growth with antagonistic effects posted by AFB1 PGR SRC SET MAPK3 PMC10378139__F2 Ferroptosis in Cancer Progression EGF EREG ACSL3 COX2 PMC5061598__F2 Proposed model for how the activation of ECM receptor pathway in the adipose tissue is linked to obesity-associated insulin resistance CD44 CD36 ATM VEGFA XBP1 PMC2835492__F4 Regulation of MUC4 expression IFNG MUC4 SKI PMC4960920__F1 Schema of upstream and downstream signaling pathways of mTORC1 RHEB TSC2 TSC1 GSK3B EIF4E PMC3336023__F3 Chronic alcohol exposure alters gene expression in HepG2 cells CRP VWF TRADD AMBP HEL111 HRG MTOR AHSG HEL-S-92n APOH PELO OSMR F2 EN1 FGA F8 TRAF2 CP PMC4073278__F7 The changes that are induced in cells by a deficiency of RPs ATR ATM MTOR ADA PMC5192018__F3 Pubertal development and regulation KISS1 GNRHR IGF1 PMC3336023__F4 Chronic alcohol exposure alters gene expression in HepG2 cells FTH1 TXN JUN HEL-S-107 CRAT FTL GCLM MAF CLPP ATF4 VCP PMC3209136__F2 Biosynthetic pathway for UA and flocculosin FAT1 FAT2 FAT3 PMC4621504__F3 Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma FLT3 RAF1 WWC3 KEAP1 EGFR AKT3 CTNND1 BRAF NTRK3 PTEN MTOR CTNNB1 FGFR2 LATS1 CTNNA3 CTNNA2 LATS2 YWHAQ NF1 AMOT FGFR4 NF2 CRB1 ERBB4 APC NTRK2 AXIN2 TSC2 MOS WWC1 PDGFRA NTRK1 NFE2L2 WWC2 PMC4593065__F1 The IGF-1R signaling network and nodes of therapeutic blockade IGF2R BAD IGF1 INSR IGF1R ARHA GRB2 MTOR IGF2 IRS1 PMC6034147__F1 Wnt signaling KLF4 IGF2BP1 APC WNT3 MTOR CTNNB1 PMC5821264__F3 Regulation of Signal Transduction by DJ-1 RHEB TSC2 TSC1 GSK3B BNIP3 PTEN MDM2 VHL PMC5821264__F2 Regulation of Signal Transduction by DJ-1 RHEB TH TSC2 TSC1 SRC HEL-S-44 PMC3295899__F2 Matricellular Protein Thrombospondin-1 Globally Regulates Cardiovascular Function and Responses to Stress via CD47 SRC CD47 PMC8491165__F1 Sphingolipid biosynthetic pathway leading to ceramide and sphingosine 1-phosphate (S1P) formation S1PR1 SPNS2 S1PR3 SMS S1PR2 S1PR5 S1PR4 PMC3929000__F1 TRAIL signalling induces the extrinsic apoptotic pathway MSC FADD PMC5821264__F1 Regulation of Signal Transduction by DJ-1 GSK3B MMP2 MMP9 MTOR PMC9456528__F2 DNA Holliday Junction: History, Regulation and Bioactivity RAD51 SLX4 EME1 PMC7917047__F5 Possible signaling pathway of MbovP280-induced apoptosis in BoMac BAX HEL-S-101 CASP9 CASP3 APP PMC3989838__F1 Insulin effects on endothelial cells TET1 IGF1R MTOR PMC8525369__F1 Gene Editing of Hematopoietic Stem Cells: Hopes and Hurdles Toward Clinical Translation CCR5 WAS BCL11A FANCA CYBB PMC4920139__F1 Genes represented in the 38-gene DTC panel and their biological pathway associations FOXA1 SNAI2 GEMIN2 IGFBP4 LAMB1 PITX2 KRT19 SFRP1 EPCAM GRB7 SNAI1 PTCH2 PTCH1 SCGB2A2 FGFR4 ERBB2 KRT7 SMO GSC HSPB8 HSPB7 TWIST1 CCND1 GLI3 PMC7872472__F1 Metabolism, pharmacokinetics and selected pharmacodynamic effects of codeine following a single oral administration to horses CYP3A4 UGT2B7 PMC2723760__F4 HERPUD1 Ingenuity Pathway Analysis illustrates interactions between indicated proteins MTHFD2 DBP BATF CREB3 VAMP3 TMBIM6 XBP1 NFIL3 ERN1 ACAT1 MDH2 ASNS SSR2 PMC8651476__F2 Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases TLR1 TLR3 TLR4 IL36G TLR5 IL36A IRF3 IRF7 TLR7 IL36B PMC3472623__F1 Folate metabolic pathway DHFR MTRR HEL-S-61p TYMS MTR PMC6608078__F2 PI3K/PTEN/AKT pathway dysregulation in prostate tumor cells HEL-S-89n PTEN IL6ST XBP1 PMC3733450__F2 Kaposi’s Sarcoma-Associated Herpesvirus G Protein Coupled Receptor: Lessons on Dysregulated Angiogenesis from a Viral Oncogene RHEB TSC2 STK11 TSC1 PRKAG2 PTEN MTOR VHL EIF4E PMC8992550__F1 Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment RAD52 RAD51 BRCA1 SSB PMC8625721__F1 NLRP3 Inflammasome in Lupus Nephritis NLRP3 TLR4 NFKB1 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC8375436__F7 Key Gene and Functional Pathways Identified in Unexplained Recurrent Spontaneous Abortion Using Targeted RNA Sequencing and Clinical Analysis IFNG STAT3 STAT1 IFNGR2 IL10 STAT4 JAK1 TYK2 GATA3 PMC12246121__F8 Distinct signaling pathways in the recognition of PAMPs and DAMPs by PRRs RYR2 CGAS TLR9 AIM2 TLR5 IRF3 IRF7 ATF2 MYD88 TLR1 GSDMD TLR3 TICAM1 TLR4 TLR8 TLR7 PMC5112586__F1 Histiocytic Neoplasms in the Era of Personalized Genomic Medicine ARAF ALK MAP3K1 SOS1 NTRK1 BRAF GRB2 IRS1 PMC12246121__F9 Transcriptional regulation in PRRs-mediated inflammatory response ME2 TLR4 ME1 MAPK6 MAPK3 PMC6271622__F1 Regulation of antioxidant and detoxifying genes by the NRF2-Keap1 pathway KEAP1 SFN PMC12246121__F4 Signaling pathways mediated by iPRRs and their regulation TIGIT CEACAM1 CD300A CSK PMC3302843__F10 Hypoxia Reduces Arylsulfatase B Activity and Silencing Arylsulfatase B Replicates and Mediates the Effects of Hypoxia HMOX1 COL1A1 HIF1A PMC12246121__F3 Structure of different PRRS in the cytoplasm and nucleus TBK1 CGAS RRM1 RRM2 AIM2 IRF3 IRF7 NAIP NLRX1 GSDMD HNRNPA2B1 MHC2TA NLRP3 PMC3118552__F7 Activation of the Stress Protein Response Inhibits the STAT1 Signaling Pathway and iNOS function in Alveolar Macrophages: Role of Hsp90 and Hsp70 STAT1 JAK1 PMC8750665__F10 Cherry Polyphenol Extract Ameliorated Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice by Suppressing Wnt/Beta-Catenin Signaling Pathway APC GSK3B CCND1 CTNNB1 PMC3334709__F4 Tau neuroinflammatory cascade CDK5 IL6 CD68 IL1B PMC7273093__F2 COVID‐19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease PRCP ACE2 PMC3697769__F2 Signaling pathways activated in cord blood-derived CD34pos hematopoietic progenitor cells (upper panel) and in erythroblasts at day 6 of differentiation (erythroblasts, lower panel) BAD FOXO1 CRKL MTOR JAK1 SHE CCNB1 DEPTOR CCND1 SET NOTCH1 PMC12246121__F2 Structure of different PRRS in the cell membrane and the extracellular CRP TH HEL-S-92n PTX3 CLEC9A MBL2 CLEC12A TIRAP IRF7 CR1 CLEC4E MYD88 PMC12246121__F1 Key discoveries in PRRs HEL-S-92n NLRP1 CGAS TLR4 INS PMC3703662__F6 Proposed model for NV-128-induced casapase-independent cell death in OCSCs BAX MTOR PMC4043860__F2 Transcriptional control of spermatogonial maintenance and differentiation ETV5 POU3F1 LHX1 GDNF FOXO1 ID4 POU5F1 BCL6B RET FGF2 PMC7746952__F1 PAR1 functions in thrombotic and inflammatory processes in the vascular endothelium TF VWF APC PMC3814888__F5 Mitochondrial activity pathway HTRA2 CASP9 PINK1 LRRK2 CASP3 PMC4685214__F1 Signaling pathways leading to gonadotropin-induced activation of MAPK3/1 in preovulatory follicles or cultured cumulus-oocyte complexes MAPK1 TNFAIP6 PTX3 STAR PGR EGFR PTGS2 AREG FSHR MAPK3 MAPK14 EREG CYP11A1 HAS2 SRC NR5A2 CEBPB PMC11019835__F1 Canonical and non-canonical function of CD55 STAT3 C6 EGF C7 HEL-S-62p GSK3B SOX2 MMP9 CD55 MYC CTNNB1 BRCA1 C2 C9 MMP2 LCK PMC10151533__F2 Developmental origin of tendon diversity in Drosophila melanogaster ROBO2 ROBO3 EGFR ROBO1 PMC10944957__F1 TGFB superfamily signaling pathway and the potential therapeutic targets in pancreatic cancer SMAD1 DKFZp781O1323 SMAD2 GREM1 SMAD4 PMC7712978__F2 P53-AB feedback loop revisited APP MTOR SIRT6 PMC8266896__F7 EGR1 and RXRA transcription factors link TGFB pathway and CCL2 expression in triple negative breast cancer cells EGR1 RXRA CCL2 PMC8292865__F2 Epigenetically inactivated RASSF1A as a tumor biomarker BAX MOAP1 CDC20 APC CCNA2 PMC6921210__F7 GEFT function and signalling pathway CDC42 ARHA RAC1 PMC9120431__F3 Engineering GD T Cells: Recognizing and Activating on Their Own Way ZAP70 IFNG SYK PCNA RAE1 PC DAP BTN2A1 VAV1 MICA GRB2 PMC3625500__F5 Overview on the mechanisms of glutathione induced cell death BAX APAF1 FADD PMC6985072__F6 Working hypothesis EGF FRK EGFR PMC10751671__F1 Impact of Physical Exercise on Melanoma Hallmarks: Current Status of Preclinical and Clinical Research IGF1 VCAM1 MTOR VEGFA PMC10751671__F2 Impact of Physical Exercise on Melanoma Hallmarks: Current Status of Preclinical and Clinical Research IFNG STAT3 BAX IGF1 IGF2 PMC7762563__F3 Ang-TIE therapeutics against diabetic retinal diseases FOXO1 RHO VEGFA PMC7762563__F2 Angiopoietin–TIE signaling pathway in the vascular endothelium FOXO1 RHO PMC8720003__F9 Study on the Mechanism of Acori Graminei Rhizoma in the Treatment of Alzheimer's Disease Based on Network Pharmacology and Molecular Docking ACHE CASP8 PGR TRPV1 MTOR TNF INS TSC2 TFF1 INSR COX2 CASP3 APP FADD PMC4220655__F2 Selective autophagy in respiratory infection and sepsis ESX1 NLRP3 TLR4 IRGM IL1B PMC4375782__F8 Interplay between glucose and leptin signaling determines the strength of GABAergic synapses at POMC neurons STAT3 POMC NPY AgRP PMC5679204__F7 Matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1 NOXA1 CD47 PMC5374883__F11 Proposed pathway of TGFB2–TLR4 signaling crosstalk in the glaucomatous TM BAMBI TLR4 MYD88 PMC5136496__F1 Apoptotic pathways BAX APAF1 PMC8135047__F1 Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis INA PMC8263657__F4 Basic approaches, challenges and opportunities for the discovery of small molecule anti-tumor drugs BAX BAD FAS TNFRSF10B TNFRSF1A MCL1 BOK TNF TNFRSF10A FADD PMC5329138__F2 Cross-Talk between the Cytoplasmic RIG-I and STING Sensing Pathways MAVS IFNAR2 IFNAR1 TRAF3 TRAF6 PMC7276545__F2 Examples of life science networks TF SI PMC4320971__F2 Sphingolipid metabolites in inflammatory disease GLTPD1 CERK SPHK2 SPHK1 PMC4320971__F1 Sphingolipid metabolites in inflammatory disease CERK ORMDL3 SMS PMC11767564__F2 Metabolic or disease regulation by LEAP-2 antagonism of GHSR1a in human organs LEAP2 COL1A1 TIMP1 NPY AgRP MTOR GCK CCL2 MRAP2 PMC4680864__F3 Proteome Analysis of Ground State Pluripotency OGDH PFKP HK2 SFN LDHB MTOR HEL-S-44 PMC7924645__F2 MSH biosynthesis and regulation in actinomycetes MTR INS PMC5069291__F1 Schematic model of the Wnt/beta-catenin pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC5069291__F2 Schematic model of the Wnt/beta-catenin pathway in Alzheimer disease NR1C1 APC GSK3B LRP5 LRP6 CTNNB1 PMC8063228__F6 Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development BAD COX1 PCNA PHLPP2 PTEN PMC4125356__F7 MicroRNA miR-150 modulates the expression of GAB1 and FOXP1 that are involved in BCR-signaling pathway in CLL B cells SYK BCR PLCG2 CD22 BLNK CD19 LYN PMC11312688__F3 Proposed Rearticulation of the Mechanism for Radiation-Induced Fibrosis: Initial radiation exposure initiates at least three distinct pathways IFNG NOX5 NOX3 IL33 DUOX1 DUOX2 SSB NOX4 PMC2972642__F2 REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy INSR F2 EEF2 ARHA CCND1 MEF2C PMC11312688__F2 Radiation Induced Skin Fibrosis (RISF): Opportunity for Angiotensin II-Dependent Intervention ADAM17 KEAP1 ACE2 SIRT1 PMC3292920__F1 Diagram shows the enzyme points (in cycle) on which the effects of n-3 PUFA might operate in the homocysteine metabolic pathway of relevance VIT HEL-S-61p MTR PMC8223458__F5 Long non‐coding RNA HOTAIR/microRNA‐761 sponge regulates PPME1 and further influences cell biological functions in thyroid carcinoma AGO2 PMC5040593__F3 Four pathways for double-stranded break (DSB) repair.Nascent DSBs are first recognized by ATM and the MRN complex that initiate a series of DNA damage response events that aim at arresting cell cycle and recruiting DSB repair proteins RAD52 BRCA1 WRN BRCA2 PARP2 RIF1 PARP1 PMC5859976__F1 Screenshot of PathwayMapper BAD INPP4B PI3 EGFR AKT3 RIT1 RPS6KA1 PIK3R1 PTEN IGF1R MAP2K1 PMC11587691__F1 Glucose metabolism in cancer cells STAT3 ALYREF HEL-S-133P HEL-S-68p F2 HIF1A MTOR CREB1 PMC11587691__F2 Lipid metabolic pathway ACLY ACSS2 FAS HMGCR CD36 SCD FADS2 GLS2 HEL-S-26 PMC8440458__F2 Farnesoid X Receptor (FXR) agonists in non-alcoholic hepatitis FGF8A CYP7A1 FGFR4 PMC12042381__F1 Neospora caninuminfection induced significant changes of metabolic profiles in caprine EECs OGDH HEL-S-133P PGM2 HEL-S-162eP ENO4 ENO1 HEL-S-87p HEL-S-30 PMC5341794__F1 PD-1 signaling ZAP70 APC IL2 PMC6538535__F3 Menin-associated pathways with potential targeted therapies JUND CDKN2C SOS1 CDKN1B MTOR GAS1 KRAS AXIN2 SST CTNNB1 PMC4259948__F1 Schematic summary of the molecular mechanisms of HLJ1 in suppressing lung cancer tumourigenesis JUND CALD1 HMGA2 TXNIP HEL57 TFAP2A YY1 CD44 STAT1 CDKN1A CCNG2 NPM1 MMP2 BCAT1 SESN2 PMC6458279__F5 Overview of the ferroptosis pathway and potential targets for pharmacological inhibition LOX GPX4 HEL-S-64p HEL-75 PMC4525315__F8 Model representing the implication of the GSK-3/Beta-catenin axis in IRF3-regulated RLR-dependent antiviral innate immunity TBK1 MAVS GSK3A IRF3 PMC8740689__F1 Multipurpose Drugs Active Against Both Plasmodium spp. and Microorganisms: Potential Application for New Drug Development DHFR PC FOS DHPS PMC7536827__F2 Proteins associated with neurotoxicity and neurodegeneration CUTA MTOR CP PMC6458279__F7 Autophagy pathway and potential targets for pharmacological modulation ATG10 TG ATG12 TFEB ATG5 PMC6458279__F1 Apoptosis pathway and potential targets for pharmacological modulation HTRA2 BAX BAD CD36 FOXO3A TLR4 FADD PMC4296672__F7 Estrogen Receptor-alpha 36 Mediates the Anti-apoptotic Effect of Estradiol in Triple Negative Breast Cancer Cells via a Membrane-Associated Mechanism LPA PC LPAR1 LPAR3 PMC5776175__F9 Model for Brucella Omp25 modulation of tumor necrosis factor (TNF)A suppression in porcine and murine macrophages TLR4 TRAF6 MYD88 PMC7156766__F5 Purine alkaloid metabolic pathway APRT ND3 ND2 PMC2829054__F7 Cdk2 Is Required for p53-Independent G2/M Checkpoint Control CDC2 ATR ATRIP CDC6 CDK2 PMC8087567__F1 How the love of muscle can break a heart: Impact of anabolic androgenic steroids on skeletal muscle hypertrophy, metabolic and cardiovascular health EGFR IRS1 PMC8138133__F6 Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells SLC3A2 GPX4 SLC7A11 COX4I2 PMC7536388__F7 Interrelations between profibrotic Smad2/3-dependent and anti-fibrotic Smad1/5/(8)9-dependent pathways in HBFs SMAD1 DKFZp781O1323 SMAD2 GC SMAD4 BMP7 PMC9563963__F3 Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells AKT3 TUG1 PMC6676114__F6 RNA MODOMICS and heterogeneity of tumors EGFR YTHDF2 BCL2 YTHDF1 MYC EIF4E PMC6132177__F1 Autophagy pathway ULK1 UVRAG MTOR PROC ULK2 PMC9131992__F4 Non-structural proteins of bovine viral diarrhea virus MAVS IRF3 PMC9655337__F6 Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis TLR4 TRAF6 TNF MYD88 PMC7605157__F2 Mechanisms responsible for the cytoprotective and antiinflammatory effects of PARP inhibitors in nononcological diseases JUN RNF146 PARG ATM CCL5 CCL2 FOS PMC3281082__F7 ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer DDR1 MTOR PMC11671467__F3 EGCG-Mediated Pathways Targeting Oxidative Stress TNF HES1 PMC5576431__F3 Downregulation of the neurotrophin-MAPK signaling pathway in DPN CRK NGF BAD FRS2 PMC11671467__F5 EGCG in inhibition of cancer growth BAX PTEN MTOR TNF PMC11375560__F4 LOX activity in promoting tumour progression in breast cancer STAT3 CRK BMP1 LOX SRC PMC5729532__F3 P53–p21–DREAM–E2F/CHR pathway FOXM1 CDKN1A E2F2 E2F4 E2F3 E2F5 PMC3775648__F4 Major elements of the Rho signaling pathway ARHGAP4 ARHA EPHA1 PMC12086034__F4 Visualize the KEGG enrichment results and mark the positions of hub genes CASP9 MAFK BAD GAL PTEN MTOR VEGFA CHAD HRAS AGER RXRA GC APP HEL-S-11 PMC7767789__F3 Metabolic abnormalities induced by hyperglycemia IGF1 HEL-S-162eP PMC5364987__F2 Different pathogenic roles of ER-resident and cell surface HLA-B27 dimers KIR3DL2 B2M IL23R PMC6387347__F1 One proposed mechanism for how vascular endothelial growth factor/neuropilin (VEGF/NRP) signaling impacts cancer stem cell (CSC) function independently of VEGFRs BMI1 NRP2 RAC1 PMC6046285__F1 Major signaling pathways activated through IGF-1R and EGF-R in adrenocortical carcinoma IGF2R EGF IGF1 EGFR IGF1R MTOR IGF2 PMC8201055__F2 microRNAs in the Regulation of Melanogenesis MC1R GSK3B TYRP1 GRB2 CTNNB1 PMC3046768__F2 Schematic of the base excision repair pathways present in mitochondria DNA2 FEN1 PMC3775648__F1 Major elements of the canonical Wnt signaling pathway WNT10B DVL1 FZD5 DKK4 WNT8A WNT16 WNT3A GSK3B WNT9B WNT10A WNT2B CTNNB1 FZD8 DKK1 WNT7A WNT1 KREMEN1 WNT4 FZD1 WNT9A DKK2 FRZB FZD2 APC LRP5 FZD7 FZD9 LRP6 WNT7B DKK3 FZD4 AXIN1 WNT3 WNT8B WIF1 PMC10889208__F1 Heterogeneity of the dermal fibroblast population HEL-S-92n LRIG1 FGF7 FBN1 PDGFRA PMC9461128__F5 Regulatory role of AP-2B in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential TF CITED2 YEATS4 KCTD1 KCTD15 PMC3775648__F3 Major elements of the noncanonical Wnt/Ca2+signaling pathway PRKD3 PLCD3 GNGT1 PRKD1 GNG5 NFATC2 GNAT2 GNG12 PRKCZ PPP3CA PPP3CC GNAZ GNAS CAMK2A GNAT3 PLCG2 PRKCA FZD2 GNB2 GNA14 PRKCI GNA11 GNG7 GNA13 GNAI3 PLCB4 GNAO1 PPP3R1 GNGT2 PRKCH PRKCB GNB1 PLCG1 PRKCE PLCB3 GNAI1 GNAT1 NFATC4 GNB3 GNG10 GNG13 GNB5 GNAL GNG3 PPP3R2 GNG8 GNA15 PLCE1 CAMK2D NFAT5 GNB4 NFATC3 GNG11 CAMK2G PMC9461128__F3 Regulatory role of AP-2B in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential TH PNMT DBH PMC3775648__F2 Major elements of the noncanonical PCP Wnt signaling pathway DVL1 MAP3K10 MAP3K13 MAP3K12 MAPK9 MAP3K11 CELSR3 MAPK8 MAP3K14 WNT5B MAP3K2 MAP3K8 MAP2K4 WNT4 ROR1 PRICKLE2 ROCK2 CELSR2 ROR2 ARHA DAAM2 RAC1 MAP3K1 VANGL1 MAP3K7 MAPK10 MAP3K6 DAAM1 PMC7768045__F4 Intramembrane proteolysis in cancer related signaling ADAM17 ERBB4 ADAM10 PMC9461128__F2 Regulatory role of AP-2B in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential CITED4 UBC CITED2 YEATS4 CITED1 SYT4 KCTD1 TFAP2B MYC PMC5055500__F2 Diagrammatic illustrations of CCN1 signaling involved pancreatic cancer progression via CCN1-Notch1-SHh axes CYR61 PTCH1 SHH SMO CCNI PMC7858151__F8 MAPs alleviates AFB1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers BAX KEAP1 PMC5357196__F3 Biosynthesis of the methylthioxylose capping motif of lipoarabinomannan in Mycobacterium tuberculosis PNP NDP PMC2902700__F6 GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE STIMULATES THE PROLIFERATION OF COLORECTAL CANCER CELLS GIP MTOR GIPR PMC6213986__F2 Pharmacodynamic mechanism of TCM against HSV-1 ELF4 MAVS TLR3 IRF3 MTOR PMC6363022__F1 Summary of interactions between ECM remodelling and kinase activity CD44 TGFBR2 STAT3 EGF LOX EGFR HTRA1 DDR2 RHO SRC TGFBR1 PMC6199805__F5 GABAergic synapse signaling pathway, with the enriched target genes highlighted in red TH PMC7381633__F6 Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway HIF1A OSBPL3 RHO PMC5817864__F1 Rapidly induced cell autonomous bypass signaling STAT3 EGFR FGFR3 IL6 JAK1 FGFR2 PMC7346753__F2 Multiple targets and multiple signal pathways of Huang Qin-Bai Shao (HQ-BS) herb pair against cancer PPARG ADRA1A GSK3B NR1C2 CHRM3 HTR2A PPP3CA CCL2 MAPK14 MAEA HMOX1 EGLN1 DRD1 ADRA1B NR3A2 KDR HSP90AB1 ADH1C NOS2 PTGER3 GSTM2 JUN SELE CHRNA7 PTGS2 VEGFA IL6 TNF NCOA1 GSTM1 RXRA ADRB2 CYP2C9 CDK2 BCL2 ADRB1 CYP3A4 PMC7481593__F2 Ferroptosis modulation in tumor IREB2 SLC3A2 FTH1 CISD1 PHKG2 KEAP1 GPX4 MT1G SLC7A11 PMC3465072__F1 Crowdsourcing Network Inference: The DREAM Predictive Signaling Network Challenge TGFA RAF1 MAP3K1 IGF1 EGFR GRB2 TRAF6 TRAF2 IRS1 PMC7481593__F1 Ferroptosis TF IREB2 SLC3A2 HMGCR STEAP3 GPX4 LPCAT3 FACL4 HEL-S-64p ADA PMC9038189__F5 Cyst lineage recovery after ablation EGF EGFR PTEN PMC8561869__F2 FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases IGF1 IRS4 IRS1 PMC9026172__F5 Pharmacodynamics, Network Pharmacology, and Pharmacokinetics of Chinese Medicine Formula 9002A in the Treatment of Alzheimer’s Disease PPARG CXCR3 TBXA2R TLR9 PLA2G1B PTPRC CTSG HDAC3 MME CSNK2A1 PTGFR HDAC2 ABCB1 CASP9 NOS2 TNF GRM2 CHRM2 RXRA OPRD1 CYP2C9 MAPK10 SIRT1 CDC42 GRIN2B BCL2A1 CHRM1 TERT HTR2A THRA CASR RARA RARB CYP2C19 S1PR2 NR3A2 CNR2 AHR CNR1 APP ABCG2 CYP1A2 ACHE CYP17A1 PTPN1 OPRM1 PTGS2 NR3C1 S1PR4 HDAC1 NR1C1 ADRA2C RELA CASP3 PTGES PMC9628328__F1 IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NFKB–Induced Inflammation MAP3K7IP1 TLR4 IRAK1 TRAF6 MYD88 PMC2696328__F5 Proposed model for the effect of HPTE in the granulosa cell SF1 GREM1 IGF1R FSHR CTNNB1 PMC550674__F2 Apoptosis mediated by death receptors requires the FADD adaptor molecule TRADD TNF TRAF2 FADD PMC3130335__F1 MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells RAF1 EGFR IGF1R IRS1 PMC8487456__F4 Quality control and recycling of peptidyl-tRNAs on stalled ribosomes NEMF ANGEL2 ELAC1 ANKZF1 HSF1 LTN1 TRNT1 PMC5802164__F6 Kyoto Encyclopedia of Genes and Genomes pathway of hsa04622: RIG-I-like receptor signaling pathway TBK1 TRADD MAVS IKBKE TANK IFIH1 DHX58 TRAF3 MAPK8 TRAF6 PIN1 AZI2 IKBKG MAPK14 RNF125 CHUK ISG15 ATG5 CYLD TBKBP1 CASP8 IRF3 IRF7 NLRX1 TRIM25 MAP3K1 ATG12 NFKB1 NFKBIA MAP3K7 DDX3X CASP10 TRAF2 FADD SIKE1 PMC371122__F7 Signaling pathway of UCP1 transcription in brown fat RXRA UCP1 ATF2 PMC8118165__F1 Pembrolizumab in unresectable or metastatic MSI-high colorectal cancer: safety and efficacy CD80 LAG3 CTNNB1 PMC3141076__F6 Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression DGAT2 HEL-S-162eP FASN DCT PDK2 MOGAT2 PCK1 PKLR GPD1 PMC4602327__F1 Major pathways of apoptosis C6 BAX BAD C7 TRADD HEL-S-62p MCL1 C9 TRAF2 FADD PMC7996143__F11 Activation of Sirt1 with SRT1720 can handle the high fructose diet-induced insulin resistance, oxidative stress, and mitochondrial dysfunction through Sirt1-PGC-1Alpha-NRF1- Sirt3-TFAM signaling pathway TFAM SIRT3 NRF1 PMC2987346__F2 RSK signaling pathway EIF4B BAD L1CAM EEF2 ATF4 GRB2 PMC3522801__F2 DNA Damage Signaling Assessed in Individual Cells in Relation to the Cell Cycle Phase and Induction of Apoptosis CDC2 BAX ATR BRCA1 PML CDK2 ATM PMC6103408__F9 IFNG-induced autophagy is regulated by HMOX1 MAPK1 MAPK14 IFNG EIF2AK4 ULK1 IRGM TFEB SQSTM1 JAK1 CEBPB MAPK3 PMC8005112__F2 Mechanisms of synergy between small molecules and immune checkpoint inhibition in melanoma APC BRAF PMC3522801__F1 DNA Damage Signaling Assessed in Individual Cells in Relation to the Cell Cycle Phase and Induction of Apoptosis BAX RAD50 MRE11A BRCA1 H2AX ATM MDM2 PMC7190807__F9 Hypothesis diagram of the regulatory mechanism of Twist1, Tie1, Tie2, Angs, and Akt/Foxo1 in endothelial cells TWIST1 PMC4180659__F1 Perpetuation of innate immune responses in sJIA TRAF6 TNF MYD88 PMC4860843__F8 Disruption of TGF-Beta-mediated tumor suppression in SCLC cells ASCL1 SMAD2 SMAD4 PMC3324026__F1 Annotation of the insulin/TOR network in Apis showing methylated and differentially methylated genes RHEB TSC2 EIF4B RICTOR TSC1 ALK BRAF PTEN HIF1A MTOR PMC7022656__F9 Cross-talks between distinct signaling pathways activated within different ER-to-nuclear responsive networks to the classic ER stressor TU DDI1 GCLM ATF4 EIF2A NGLY1 NRF1 XBP1 DDI2 PMC11880501__F7 Working model ZFP36 LRP5 PMC6756575__F4 Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis THBS1 CXCL13 C5AR1 GNG13 NPY1R CD19 MMP9 IL6 CSF3 CXCL8 SPP1 P2RY14 HMOX1 POSTN CCL19 ANGPT1 PMC6756575__F3 Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis HS3ST2 OGT PPIB C7orf11 LDB2 CYP2E1 PAX4 CYCS LMF1 KRT16 ZNF652 TSN DDR2 EFS ARHGAP26 POSTN LRRC2 SPAST GNL3L KRT7 MRPL47 ITPKC GGH BCHE SOX4 PRRG4 IRX3 F2RL3 KRT4 MED21 CBLN4 SLC35A1 HSPB3 FCRLA SLC43A2 AGR3 PTCH1 ECM2 EDNRB PRRT2 AKAP12 ACTG2 DNTTIP2 SPOPL PLN PTX3 COMP FOXE1 TSNAX TANK SFN CSF3 DST ROBO2 HTR2B HOXA2 SBF2 SUMO1 ACTA2 SLIT2 CX3CR1 TNFRSF17 ATM ITM2A DKK2 RAB23 RND1 LTBP2 CXCL13 INMT ASPN FOLH1 SFRS3 CIRBP LIF HMCN1 PHLDA2 SBSPON ANKMY2 SDC1 TMEM201 SPP1 MYOC PDF FIBIN NR2F2 AGER ITPRIPL2 SPPL2B CHMP4B CRHR2 RDH10 KIAA2012 ENPP2 NAP1 SCN4B PMC7226501__F8 Regulatory model of VP4 in antiviral signaling in grass carp TBK1 IRF3 IRF7 MYD88 PMC8006920__F4 Pathway enrichment of hubs: The common pathway (red rhombus) shared by three protein hubs (yellow rectangle) extracted from the metalloprotein network HSP90AB1 ELL MTOR PMC7022656__F1 Inhibition of Nrf1 N-glycosylation by tunicamycin (TU) in the endoplasmic reticulum (ER)- to-nuclear signaling responses ATF4 EIF2A NRF1 XBP1 PMC10508215__F1 AKR1C3 Converts Castrate and Post-Abiraterone DHEA-S into Testosterone to Stimulate Growth of Prostate Cancer Cells via 5-Androstene-3B,17Beta-Diol CYP17A1 CYP11A1 HSD3B1 AKR1C2 AKR1C1 STS PMC8867758__F4 MicroRNA regulates the toxicological mechanism of four mycotoxins in vivo and in vitro BAD PAK4 FOS PMC6254932__F6 VHL-HIF-BNIP3 signaling pathway EGF TGFA BNIP3 VHL PMC5927447__F10 NF2 signaling pathway plays a pro-apoptotic role in Beta-adrenergic receptor stimulated cardiac myocyte apoptosis BAX NF2 PMC5596881__F2 Therapeutic targets in Nrf2-dependent protection against neonatal respiratory distress disease predicted by cDNA microarray analysis and bioinformatics tools HEL-S-25 CXCL3 MYD88 HMOX1 ANGPT1 E2F4 WAC WAS TRAT1 AAG1 FGFBP1 CSF2 SORD BSCL2 AREG RAD21 GSTA3 HEXA POLA1 CDKN1A IL1RN GCLC MCM5 CDCA7 BIRC6 HEL-S-61 TIMP1 SLC7A11 CEP192 GDF15 RAG1 SRXN1 HEL-S-72p PRDM8 AOX1 UBC EGR1 GLIPR1 MAP4K1 RRM2 CD14 ME1 IL6 CXCL6 IFT80 MKI67 FIBIN FTL PRKDC NFAT5 PIR NFATC3 GTF2I TOMM20 PRSS35 CD3E LCK FAT3 PMC5858488__F1 MTOR signaling pathway MLST8 TSC2 RICTOR TSC1 EGFR PTEN MTOR PMC10377491__F1 Landscape of Small Leucine-Rich Proteoglycan Impact on Cancer Pathogenesis with a Focus on Biglycan and Lumican STAT3 HMGB1 FBXW7 FAP PMC3128635__F2 Crosstalk and feedback in ERK and PI3K signaling downstream of RAS PTEN IRS1 PMC3128635__F1 RAS signaling to the PI3K pathway TSC2 BAD RICTOR PTEN GRB2 MTOR IRS1 PMC4447220__F6 Conceptual model of the effects of 15-LOX-1 on the PPARD–IL-6/STAT3 signaling pathway in relation to colorectal tumorigenesis STAT3 MUC1 NOTCH3 PMC10341567__F4 Major pathways and interactions regulated by BACE1: (A) Notch signaling pathway, (B) Amyloidogenic pathway, and (C) NFKB pathway BACE1 GSK3B NOTCH1 PMC10341567__F3 Major pathways and interactions regulated by GSK3B: (A) Wnt/B-catenin pathway and (B)PI3K/Akt/mTor pathway APC GSK3B MTOR CTNNB1 PMC10341567__F6 Major pathways in which ABCA1 plays an important role for cholesterol transport in brains: (A) Reverse cholesterol transport pathway, (B) LXR/RXR pathway, and (C) SREBP2 pathway SCARB1 CD36 ABCA1 PMC10341567__F5 Major signaling pathways that regulate SREBP2 activation during cholesterol synthesis: (A) P53 pathway, and (B) Akt pathway RHEB TSC2 GSK3B ARHA ABCA1 PMC8795088__F5 Striatal Chloride Dysregulation and Impaired GABAergic Signaling Due to Cation-Chloride Cotransporter Dysfunction in Huntington’s Disease HEL-S-29 BDNF HTT PMC10341567__F7 TREM2/DAP12 pathway TREM2 SYK APOE GSK3B CTNNB1 PMC9038119__F1 Targeting metabolic pathways for extension of lifespan and healthspan across multiple species OGA HEL107 OGT HEL-S-162eP PMC8045214__F9 Association of cyclin-dependent kinase inhibitor 2B antisense RNA 1 gene expression and rs2383207 variant with breast cancer risk and survival GATA2 SUZ12 REST ZNF610 KLF8 MYC CTCF ZNF2 PRC1 SP3 ZNF423 AHR ZNF71 PMC11969919__F4 Transcriptome profiles of blastocysts originating from oocytes matured in follicular fluid from preovulatory follicles of greater or lesser maturity KLF3 PCDH17 HHEX APC KIF3B DBT MGST1 CCND1 AXIN2 CTNNB1 PMC9038119__F3 Targeting metabolic pathways for extension of lifespan and healthspan across multiple species HPD NAPRT KYNU NAMPT AFMID PMC9038119__F5 Targeting metabolic pathways for extension of lifespan and healthspan across multiple species APRT PAICS ADK XDH ADSL PMC10341567__F1 Main pathways involved in cholesterol transport involved in Alzheimer’s Disease TREM2 APOE BACE1 GSK3B APP CYP46A1 ABCA1 PMC8913803__F3 Signaling pathways and targeted therapy for myocardial infarction NLRP3 TIRAP TRAF6 MYD88 PMC8913803__F2 Signaling pathways and targeted therapy for myocardial infarction JAM2 GSK3B EZH2 PTEN CS NOTCH2 NOTCH3 NOTCH1 PMC10834963__F8 Proposed signaling mechanism for the effects of amlexanox on LPS-induced neuroinflammation in BV2 microglial cells STAT3 CXCL10 CCL2 PMC5272937__F1 The HCV interactions (both direct and indirect) on the hepatocyte insulin signaling pathway PKD1 PI3 MTOR IRS1 PMC5419442__F9 Possible Signaling Pathway that Mediates FSH-Induced Meiotic Resumption of Mouse OocytesAfter binding with its membrane-integrated receptor in cumulus cells, FSH uses PKAII as a downstream mediator after a transient increase of cAMP EGFR FSHR PMC6887669__F1 Two‐signal model of inflammasome signaling NLRP3 IL16 IL1B PMC8765442__F2 Heart Failure with Targeted Cancer Therapies: Mechanisms and Cardioprotection FLT3 RET PMC6735914__F3 DAXX in cell death FAS ULK1 PML TGFBR1 TRIM21 TGFBR2 RIPK3 FTH1 HIPK2 PIAS1 BCL2 RIPK1 TRAF2 FADD PMC8100458__F2 Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy CDC42 HGF APC ARHA MMP9 NOTCH3 CTNNB1 PMC8913803__F5 Signaling pathways and targeted therapy for myocardial infarction STAT3 STAT1 EPO JAK1 PMC8913803__F4 Signaling pathways and targeted therapy for myocardial infarction POR ROCK2 KEAP1 ROCK1 ARHA NOTCH3 PMC8913803__F7 Signaling pathways and targeted therapy for myocardial infarction LATS1 LATS2 SHH ERBB2 SMO SRC SKI PITX2 PMC8913803__F6 Signaling pathways and targeted therapy for myocardial infarction SMAD2 APC GSK3B LRP5 SMAD4 LRP6 KLF5 DKK2 CTNNB1 PMC5869932__F2 Roles of ZBTB proteins in B-cell development, differentiation, and function ZBTB32 PRDM1 PAX5 ZBTB7A PC ZBTB1 BCL2 IL7R IRF4 PREB BCL6 ZBTB24 PMC3757945__F3 Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair LATS1 LATS2 APC GSK3B IGF1R CTNNB1 PMC8948957__F2 Combined Targeted and Untargeted Profiling of HeLa Cells Deficient in Purine De Novo Synthesis PAICS HEL-S-70p PFAS ADSL PMC2661568__F6 Schematic model of sequential hippocampal aging changes APOD APOE SOAT1 PMC4185356__F1 Control of endotoxin tolerance by AhR TDO2 IDO1 TLR4 AHR PMC3904516__F8 LPS-Stimulated Inflammatory Environment Inhibits BMP-2-Induced Osteoblastic Differentiation Through Crosstalk Between TLR4/MyD88/NFKB and BMP/Smad Signaling SMAD1 COL1A1 TLR4 BMP2 SMAD4 RUNX2 IL1B MYD88 PMC10886830__F7 Toll-like receptor (TLR) signaling pathway with a focus on TLR4 TLR4 TRAF6 TNF MYD88 PMC6835115__F3 Targeting PKCι-PAK1 in EGFR-mutation positive non-small cell lung cancer STAT3 AXL PAK1 ECT2 EGFR SRC RAC1 YAP1 CDCP1 PMC6311107__F2 Simplified model of the molecular pathways by which pazopanib and AR42 combine to kill cancer cells BAX TSC2 BAD RAF1 HDAC10 ULK1 ATM HDAC11 MTOR EIF2A HDAC2 HDAC6 PMC6478125__F1 RUNX3 and p53 act independently and in concert to elicit their tumour suppressive function ATR ATM BRD2 RUNX3 PMC6311107__F4 Simplified model of the molecular pathways by which neratinib and valproate combine to kill cancer cells ERBB3 ERBB4 ULK1 PDGFRA ERBB2 ATM MTOR EIF2A ATG5 PMC8634264__F2 Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects TMPRSS2 KEAP1 ACE2 PMC4773033__F2 Comprehensive picture showing gene expression changes and crosstalk of pathways associated with Igf1 and Pacap rescue of apoptotic CGNs DUSP5 CXCR3 HEL-S-103 FGF21 PIPOX HEL-S-51e WNT5B NGF FYN GRIN3B CX3CL1 HSPA2 FGFR1 SHH ITK GALR2 WNT4 HEL-S-283 CACNA1S GSTM2 CERS2 IRS1 HRAS GSTA3 AGXT ITGB1 IGF1 SUFU RAP1A PTCH1 CORO1A GRB2 CXCR4 PSPH PMC4993794__F1 Tarp protein mediated signaling pathways implicated in chlamydial entry and development SYK SOS1 VAV2 TARP SRC PMC3788606__F3 TGFB signaling TGFBR2 RHO SKI TGFBR1 PMC12066627__F1 Molecular and cellular signaling of intestinal tuft cells in response to infections IL25 PLCG2 SPIB ChAT PMC3306981__F1 Summarized the signaling mechanisms of various matricellular proteins contributing to cancer progression TNC SPARC HEL-S-28 RHO LEF1 PMC4839364__F1 (T)cell-inflamed and non-(T)cell-inflamed phenotypes CXCL9 CXCL10 CD8A PMC4497751__F2 MicroRNA regulation of lymphocyte tolerance and autoimmunity TSC2 PTPN22 BAD BTK TSC1 PHLPP2 PTEN MTOR PMC9250769__F1 Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis MATK KIN PMC6610456__F1 TRAFs in IL-17 signaling pathway USP25 TRAF4 IL17RC TTBK1 ARID5A EBP EGFR TAB3 TRAF5 TRAF3 TRAF6 TRAF2 PMC8283906__F3 Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target TLR9 CCDC25 MPO PMC10731584__F7 Simplified de novo sphingolipid biosynthesis pathway UGCG FA2H KDSR PMC6505627__F2 BCR: a promiscuous fusion partner in hematopoietic disorders BCR PDGFRA FGFR1 RET PMC11273247__F11 Sodium sulphate ameliorates hypercholesterolemia and hepatic insulin resistance in mice fed an HCD CYP7A1 FGFR4 IRS1 PMC4751708__F2 Gene networks PIK3CA DTX3 NUMB DVL2 CARD6 KRAS RBPJ NCOR2 IFNG PSENEN RIPK2 ADAM17 PDPK1 CREBBP SNW1 MDM2 DLL3 HES1 CARD9 PMC8270322__F1 Pros and Cons of the Cannabinoid System in Cancer: Focus on Hematological Malignancies BAX PIGF CDK2 PMC6338329__F7 Mechanisms for human cervical epithelial cells (HCEs)-mediated HIV suppression in macrophage STAT3 STAT2 IRF9 IRF3 IRF7 STAT1 TLR3 IFNAR2 IFNAR1 ISG15 OAS1 TYK2 OAS2 PMC3643422__F1 Illustration showing the overall sex hormone metabolic pathway and subpathways STAR SHBG PGR NR3A2 PMC7261174__F10 IKBKE mediated AR signalling LATS2 IKBKE MYC PMC4334626__F1 Proposed schematic model showing how the crosstalk between healthy or oxidized/senescent red blood cells (RBCs) and immune cells may exert anti- and proatherogenic effects, respectively TH ICE1 IL16 PMC3220493__F6 Schematic model in which FGF2 stimulation of osteoblast differentiation is partially through modulation of the Wnt/Beta-catenin pathway WNT10B GSK3B LRP5 LRP6 ATF4 RUNX2 CTNNB1 FGF2 PMC5270455__F15 Directional pathway satisfying TIM of Table TGFBR2 HDAC1 EGFR PMC5270455__F14 Directional pathway satisfying TIM of Table TGFBR2 HDAC1 EGFR PMC4286365__F1 Biosynthetic and recycling routes in MDCK cells: the new paradigm LDLR PIGR PMC7355786__F3 Mechanism of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway RHEB TSC2 TSC1 PTEN PMC7859603__F1 DisGeNET contains a list of diseases associated genes that have been collected based on the presence of genetic overlaps between diseases TBX2 STAT3 PPARG MYB FAS TGFBI EGFR IL3 IL2RA CCL2 IFNG HLA-DRA NLRP3 MHC2TA HLA-G MMP3 IL2 CEBPB ABCB1 NR1i1 NOS2 IL10 JUN SELE APC CD14 IL17A IL6 TNF TG RELA APOB BCL2 PMC3121446__F6 P53 activation by NML-MYBBP1A in response to glucose limitation MYBBP1A MDM2 PMC5737867__F5 The involvement of the brain-derived neurotrophic factor (BDNF)-glycogen synthase kinase-3B (GSK-3B)-Beta-catenin pathway in the antidepressant-like effects of Morinda officinalis oligosaccharides (MOs) and resilience to stress MOS GSK3B BDNF CTNNB1 PMC7240858__F1 Innate immune checkpoints influencing DC function in the TME CD80 HMGB1 CD24 PROS1 MUC1 SIRPA BTLA LILRB1 CD47 PMC9608343__F1 Metabolic features of myeloma cells in the context of bone microenvironment: Implication for the pathophysiology and clinic of myeloma bone disease WNT10B PDF WNT3A MSC PTH RUNX2 PMC8126571__F1 Bidirectional microglia–neuron interactions in the healthy or stressed brain HMGB1 CSF1 BDNF IL1B PMC86258__F8 Shc/Grb2/Gab2/PI-3K Akt pathway IL15 IL3 GRB2 SHE IL5 GAB2 PMC5935908__F8 NRP-1/TNC/Integrin B3/FAK/Akt/NFKB schematic signaling pathway TNC GSK3B NRP1 ABCG2 ITGB3 PMC7417304__F4 Emerging roles of Hippo-YAP signaling in the modulation of innate anti-tumor immunity LATS1 CSF1 IL13 IL4 MYD88 PMC6121402__F1 Mammalian target of rapamycin (mTOR) pathway RHEB TSC2 TSC1 TBC1D7 IRS1 PMC7417304__F1 Signaling mechanism and regulation of the Hippo pathway in drosophila and mammals LATS1 MOB1A PMC3109273__F1 Host cell death pathways targeted by L BAX SDHA BNIP3 PMC7417304__F3 Hippo pathway in innate antiviral immunity LATS1 TBK1 LATS2 CGAS MAVS IRF3 TRAF3 MYD88 PMC7417304__F2 Hippo pathway in innate anti-bacterial immunity ECSIT TBK1 IRF3 IRF7 TRAF3 TRAF6 RAC1 IRAK4 MYD88 PMC4012154__F1 Signaling pathways involved in microglial phagocytosis CDC42 TREM2 SYK IRAK4 MYD88 PMC9477794__F2 Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy NLRP3 RELA IL1B MYD88 PMC8005405__F2 Mechanisms regulating ROS in LSCs FIS1 TPO PMC3197200__F2 Intracellular signaling pathways regulating growth IGF1 FGFR3 PTEN IGF1R EIF4E PMC8587556__F4 Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease ROR1 APC ROR2 GSK3B LRP5 LRP6 RYK CTNNB1 PMC3214149__F3 Schematic overview of CagL and CagA-mediated signal transduction pathways involved in H CRK ASB1 CSK RAC1 PMC8618071__F7 Fungicidal Activity of Recombinant Javanicin against Cryptococcus neoformans Is Associated with Intracellular Target(s) Involved in Carbohydrate and Energy Metabolic Processes PDC HBD CS PMC8056183__F2 Cell death pathways and viruses: Role of microRNAs MLST8 ULK1 MTOR DEPTOR PMC4989102__F6 Network motifs that are coordinately regulated by the miR-17–92 cluster DUSP5 TF DUSP10 TAOK1 JUND MAP4K3 PPP3R1 CRK MAP3K1 RASA2 RAP1A PRKX NLK RPS6KA3 MAP3K5 RPS6KA5 DUSP7 PMC8056183__F1 Indirect effects of viruses on the apoptotic pathway through deregulation of cellular miRNAsmiR-2861 increased the apoptosis of cervical cancer cells through the PI3K/AKT pathway by targeting EGFR BAX BAD TRADD SMAD2 SMAD4 BCL2 PTEN SMURF2 SRC TRAF2 FADD PMC6490153__F6 Pathway summary of a host defense mechanism response to bacterial meningitis caused by Streptococcus pneumoniae RB1 BAX BDNF PMC10340243__F5 The main metabolic pathways of unsaturated fatty acids LOX ALOX12B ChAT ALOX12 PMC7364557__F2 Model for tau pathogenesis CDK5 FYN NLRP3 CX3CR1 PMC7364557__F1 Model for ABeta-induced neurotoxicity and glial response in AD AQP4 SYK CD36 APOE EPHA4 CD47 CASR TREM2 EPHB2 FYN LILRB2 TLR4 APP PMC2698768__F9 Model of CD28 signaling pathways initiated by the distal and proximal motifs GSK3B PMC5295004__F8 Proposed model of selected miRNA action on the regulatory T cell pathway DKFZp781O1323 CTLA4 FOXP3 RUNX3 PMC3580185__F7 Working model for the role of TAK1 lysine-72 in the negative regulation of TNFAlpha-induced NFKB activation CSA2 TRADD RELA REL TNF TRAF2 PMC8347056__F3 Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology ORAI3 ORAI1 STIM1 PMC5490254__F2 WNT and SHH signaling pathways APC SHH SMO PMC4375971__F1 Obesity genetics in mouse and human: back and forth, and back again STAT3 SIM1 TUB LEPR POMC MC4R MC3R NPY AgRP SH2B1 BDNF MRAP2 PMC5370457__F1 Mechanism of signaling transduction of vascular permeability CDC42 MLPH ARHA TNF PMC5646121__F3 Direct and indirect targeting of the B cell receptor signaling pathway CD79B SYK BTK BCR PLCG2 BLNK CD19 MTOR PMC6277481__F1 Genetics and molecular pathways for PPGLs Pathways for the New Genes; Placing the New into Perspective MAX HRAS TMEM127 MYC APAF1 SDHAF2 RET PMC8891265__F1 Diet, lipids, and antitumor immunity ACLY FAS SCD HEL-S-5 SLC25A1 PTMS PMC2978917__F7 Signaling pathway and transcription factors involved in HPR1 gene expression in cancer SPIC EGR1 SP1 EGFR PMC4259002__F4 Epidermal growth factor receptor pathway STAT3 EGFR MTOR PMC10478470__F2 HMGB1 and TLRs signaling pathway HMGB1 TLR1 TLR3 TLR4 TLR9 TLR8 TLR5 TLR7 TNF MYD88 PMC6329348__F3 Assessment of in vivo genotoxicity of citrated-coated silver nanoparticles via transcriptomic analysis of rabbit liver tissue AURKA CABL1 EXOC4 NEIL2 CKS2 GUCY2C NEK9 PSMA2 VCP C1D DUSP14 HOPX CDC2 VWF CAST GSTM2 REST CDH17 TP53INP1 HEL-S-133P DKC1 BPI ERC2 HEL-S-94n ANGPTL4 ERAP1 SUFU ZNRF3 C16orf35 MCM6 PMC8428079__F2 Targeting Beta-cell dedifferentiation and transdifferentiation: opportunities and challenges CDC42 MYLK TRADD MAFA PDGFRA RELA RELB TNF INS TRAF2 RAC1 FADD PMC9621333__F1 Epstein–Barr virus infection, B‐cell dysfunction and other risk factors converge in gut‐associated lymphoid tissue to drive the immunopathogenesis of multiple sclerosis: a hypothesis BCR HLA-DRB1 PMC2801177__F4 Identification of candidate molecular network for miRNAs most highly changed in response to DEP BMPR2 ACVR2B TNPO1 PLK2 TRPC1 HEL-S-89n PTEN NCOA1 PITX2 GATA3 NR3C2 CUL4A ZBTB44 BMP2 CFTR SNAP25 DNAJA2 NR5A2 CEBPB NR3B3 PMC2801177__F3 Subnetworks of select putative DEP-regulated gene transcripts show an enrichment of inflammatory response SCARB2 PDPN DUSP5 APPL1 TMEM109 LRAT GNG12 WIPF1 SOX6 CAMK2N1 SNN ROCK1 RBM7 PROS1 CNR1 ADCY6 PRKAR1A AMPH GNG13 PITPNB CD40LG TNF KRAS PITX2 HMGCS1 ARHGAP5 MCHR2 VPS35 GRSF1 HBEGF CUL4A TACC1 CCL25 RGS5 CFTR XDH CXCR4 SOCS6 CP PMC2242778__F5 Canonical pathway analysis CRK PXN ARHA PMC9636380__F1 Activation of RIPK3 by multiple stimuli RIPK3 ZBP1 TLR3 MLKL TLR4 RIPK1 PPM1B PELI1 TRIM21 PMC6085908__F1 Synaptic signaling pathways associated with autism spectrum disorder (ASD) UBE3A CACNA1C HOMER1 GSK3B PTEN MTOR ARC EIF4E RHEB TSC2 SYNGAP1 TSC1 NF1 BDNF PMC5415789__F6 CeRNA network modulates the PI3K/Akt signaling pathway EIF4B SGK1 EGFR PTEN VEGFA MYC KRAS RAC1 IRS1 EIF4E RHEB OSMR RELA ATF4 GRB2 CDK4 PMC6468516__F2 Metabolism in tumor cells HEL-S-162eP CS GRB2 PMC8221295__F6 Mechanistic insights into the anti-depressant effect of emodin: an integrated systems pharmacology study and experimental validation MAPK1 IL10 GSK3B PTEN VEGFA IL6 TNF INS KRAS FGFR2 IGF1 CYP2C19 FGFR1 IL2 CYP2C9 MAP2K1 MAP2K2 TYMP CREB1 HEL-S-44 IL1B PMC2822054__F1 How the PI3K-AKT and MEK-ERK pathways regulate apoptosis in EGFR driven cancers ERBB3 EGFR MDM2 GRB2 MYC CCND1 PMC4632093__F1 Nodes-and-connections strategy generating an interaction map of signaling molecule network required for the fulvestrant-induced MCF-7 cell apoptosis STAT3 ERBB4 F2RL3 PAG1 CAMK1D PRKCZ MAPK9 MYLK3 NR3C1 PAWR ROCK1 MYL2 CSK CALM1 DAPK2 CAMK4 ATF4 MAP2K2 SRC GRB14 BIK PMC8759533__F1 ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition CBL ALK PTPN11 MTOR CCND1 PMC4252654__F1 MANNOSE METABOLISM: MORE THAN MEETS THE EYE GMPPB MPDU1 DPM2 DPM1 DPM3 PMC8707026__F1 Molecular Rationale of Insect-Microbes Symbiosis—From Insect Behaviour to Mechanism TF TRAF3 PMC6300778__F8 JAK2/STAT3 mediated protection of APN against OGD STAT3 ELL PMC11878481__F1 Autophagy by mTORC1 and AMPK TSC2 ATG3 ATG12 ULK1 TFEB ATG5 PMC8185197__F1 Hereditary Leiomyomatosis and Renal Cell Cancer: Recent Insights Into Mechanisms and Systemic Treatment RPS6 SLC11A2 ACACB FH HEL-S-133P ACACA VEGFA PMC9179253__F2 New Therapeutic Strategies for Adult Acute Myeloid Leukemia FLT3 FGFR1 MTOR FGF2 PMC5242532__F1 Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1 LATS1 FAT4 CD44 RASSF6 CRB1 LATS2 PARD3 TP53BP2 AMOT AJUBA PMC3673784__F1 Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition JUN TNKS2 SMAD2 GSK3B TCF4 WNT2B BIRC5 FZD3 TNKS CER1 CSNK2A1 DVL3 WIF1 PMC7012784__F2 Anti-tumourigenic JNK signalling ROBO2 SCRIB PMC4465694__F8 Rapamycin Enhances the Anti-Cancer Effect of Dasatinib by Suppressing Src/PI3K/mTOR Pathway in NSCLC Cells FOXO1 MTOR SRC PMC9263135__F9 Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer COMP KEAP1 OTULIN TLE4 PRKCZ MAP2 AMER1 PRKCI FBXW7 E2F3 NFE2L2 ATM MDM2 CCND1 RET PMC7012784__F5 Upstream regulation of JNK signalling TRAF4 ATF3 PPM2C HEL70 TRAF6 TNF RAC1 PMC4059866__F4 Gene network generated by Ingenuity Pathway Analysis of 5 genes identified to be predicted targets of miRNAs associated with in vitro cisplatin resistance (fold change > 2, P < 0.05) in the current study TP73 SUMO1 ANKRD17 SMC1A PMC5302293__F1 Cell-cycle and DNA repair BAX CASP9 MYOD1 JUN PCNA BNIP3 SFN PTEN TNF RB1 XRCC5 STAT1 CCNE2 BIRC5 CDK6 CDKN1A FOXO3A CASP3 CDK2 GADD45A APAF1 CDK4 PMC4721605__F2 Key signaling pathways that regulate activity-dependent translation initiation in neurons RHEB TSC2 EIF4B TSC1 IGF1 PAIP2 PTEN ATF4 EIF2A EIF4E PMC2726720__F3 Interplay of TGFB, Wnt/Beta-catenin, Hedgehog, and Notch in stem cell differentiation and tumorigenesis SMAD4 CDK4 PMC7193059__F1 Neurotoxicity of local anesthetics in dentistry BAX BAD FADD PMC12218202__F6 Chlorophyll synthesis and degradation of tomato leaves in WT and slprr1 lines under SD or LD conditions POR CPO UROD MGMT UROS PMC7604390__F1 Model showing intracellular lipid metabolism and AA metabolism in ovarian cancer ACLY LPA CIC FABP5 COX2 CD36 FASN LDLR PMC12020288__F1 Mechanism diagram of RBPs in HCC CCDC137 FUS STAT3 SPATS2 HNRNPL NDRG2 IGF2BP3 RALY EIF3A IGFBP2 YTHDF1 PUM2 RPS7 EIF4E GRSF1 MEX3C MSI1 PNO1 PTBP1 EEF1A2 EIF5A2 RBM3 PMC7168513__F4 DENV‐mediated activation of the cytosolic DNA‐sensing pathway in DCs TBK1 CGAS IRF3 PMC12020288__F3 RBPs as potential therapeutic targets for HCC RBM38 RBMX CLDN6 GRSF1 DTX3 BLACAT1 TARBP2 IGFBP2 YY1 YTHDF1 CLDN1 PMC3131055__F1 Wolbachia-induced responses of specific cell types CD40 CD80 TLR3 TLR4 MAL CXCL1 TLR9 CD14 CXCL2 IL1B MYD88 PMC7168513__F1 Cytosolic DNA‐sensing immune response via cGAS/STING TBK1 CGAS IRF3 TREX1 PMC3870290__F4 Potential mechanism of AICD-mediated gene regulation IDE MED12 HEL-S-62p APP LBP PMC5795380__F1 Protein subnetworks of Ras (the query protein) with Raf and ERK1/2 ARAF RAF1 SOS1 SHOC2 BRAF MAP2K1 MAP2K2 KRAS PMC3870290__F1 Proteolytic processing of the amyloid precursor protein (APP) and Notch IDE BACE1 APP PMC10908104__F2 ALS disease pathological signaling pathway FUS HEL-S-44 C9orf72 PMC5715491__F7 Pathways involved in apoptotic and EMT effect by genistein in HT-29 cells CDH2 BAX TWIST1 PMC10855445__F3 Interaction between ALR, NLR, and cGLR (cGAS/STING signaling pathway) NLRX1 CGAS NLRP3 NLRC3 AIM2 IRF3 USP21 PMC4049863__F3 Rho-GTPase signaling in leukocyte extravasation ARHA PMC5332883__F1 For PD-L1 modulation in HNSCC STAT3 STAT1 PI3 EGFR PTEN PDK2 PMC4786284__F6 Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway SUFU DHH SHH PMC9185718__F5 An effective nano drug delivery and combination therapy for the treatment of Tuberculosis INHA HEL-S-5 CASP3 IRAK1 FADD MYD88 PMC7613405__F4 Notch signaling pathway and the processes of lateral inhibition and induction FH NOTCH2 NOTCH3 NOTCH1 PMC3673714__F2 miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy TIMP3 PTEN CTNNB1 PMC6826985__F7 Gene activities in the TGF beta signaling pathway BAMBI IFNG FST SMAD2 SMAD6 SMAD4 SKP1 NODAL ARHA MYC PITX2 TGFBR1 PMC6826985__F6 Gene activities in the calcium signaling pathway PLN CAV3 CAV2 BCR APLN MCU PMC1869626__F2 Pathway analysis was performed using PathwayStudio software by importing three of the 32–up-regulated genes in our list SCD AHR ASNS PMC7358455__F9 Schematic illustration showing the mechanism of melatonin(Mel)sensitises shikonin(SHK)-induced cancer cell death SIRT3 ME1 PMC6826985__F5 Gene activities in the cytokine-cytokine receptor interaction pathway CD40 TRO LTA FAS LEP LTBR OSM INHBC CCR2 EPO CCL2 IL11RA CSF3 MPL IFNK INHBA INHBE FLT4 EPOR IL2 KDR AMH GHB2 IL10 GAL SP1 IL34 LEPR LIF IL4 KIT IL20RA VEGFA TNF LTB CNTF IL2RB BMP2 EDAR TNLG7C ACR PMC3961361__F8 MAVS-MKK7-JNK2 Defines a Novel Apoptotic Signaling Pathway during Viral Infection MAVS TRADD IRF3 TRAF3 TRAF6 CYLD PMC4209417__F2 Insulin-like growth factor-I receptor signaling pathway BAD PCNA PTEN GRB2 MTOR IRS1 PMC9313262__F5 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) VWF AURKA TNC HEL113 KIF11 PLAUR NOP2 ITGA2 TTK CALM1 ARHGAP18 SERPINB2 MAP2K3 PMC9313262__F4 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) HEL113 ITCH MTA2 PLAUR FNDC3B GRN HMGCS1 TPM1 CRK STAT1 DKK1 ITGA2 NPM1 CCDC80 MAP2K3 DCN CCND1 HEL-S-44 PMC6923859__F3 Wingless (WNT)-signaling pathway as a central way to Braford anti-tick resistant (R) response ENC1 TIMP1 HGF EGFR GSK3B MYC CCL2 SKP2 CTNNB1 FRAT1 CCND2 MMP26 BMP4 WNT7A ATF1 TBX3 PLA2G7 CCND1 CCR1 MMP7 ID2 PLD2 FZD2 PLAUR APC LRP5 FZD7 FZD9 LRP6 OLIG2 HEL-S-28 VEGFA SHE AXIN2 SFRP1 CD44 TCF7L2 NOTUM DVL3 WNT3 ADAM10 GLI3 PMC9313262__F3 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) AURKA HEL113 COL1A2 PLAUR VTN GRN CRK COL1A1 DKK1 NPM1 CALM1 CCDC80 INPPL1 CNBP CCNB1 MAP2K3 DCN CCND1 HEL-S-44 PMC9428246__F2 Propofol on macrophage activation and function in diseases STAT1 HMGB1 NLRP3 IL13 TLR4 GSK3B FOXA2 IL6 SRC ABCA1 PMC4245043__F1 Model of the Fanconi functional pathway and protein components ATR BRCA2 FAN1 FAP PMC3478095__F2 Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease AGO4 DGCR8 AGO1 AGO2 DICER1 DROSHA PMC9428246__F4 Propofol on macrophage activation and function in diseases STAT3 MRC1 TLR4 ARG1 IL6 CXCL10 TNF PMC9313262__F6 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) PTX3 HEL60 C7 STAT2 APOL2 FKBP9 HMGCS1 STAT1 ADAM17 COL12A1 SERPINB2 IFNB1 HLA-A HEL-S-44 PMC4290619__F8 Signaling pathway of coagulation cascade for schizophrenia TF DRD2 F5 F10 F3 F7 F11 F8 F9 TFF3 DRD3 PMC10311035__F3 Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders MLST8 TSC2 TSC1 APC CTNNB1 PMC7378668__F7 Genes and processes involved in the 04662.B cell receptor signalling pathway SYK CD81 BTK BCL10 BCR CD72 ELL CD22 BLNK CD19 LYN GRB2 PMC6614345__F3 Differentially expressed miRNAs in thyroid cancer tissues modulating the TGFB pathway TGFB1 SMAD2 SMAD4 TGFBR1 PMC8689584__F2 The major DNA damage repair pathways impaired in HPV-positive cancers RB1 ATR RAD51 RNF168 BRCA2 CCND1 TRIP12 PMC10311035__F2 Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders SMAD1 DKFZp781O1323 DLL4 APC SMAD4 SFRP1 CTNNB1 LATS1 LATS2 SOST DKK1 SUFU SMO NF2 DLL3 PMC11188434__F0 GUP can effectively inhibit the activation of cGAS-STING pathway induced by multiple stimuli and reduce the expression of type I interferon and pro-inflammatory cytokines CGAS IRF3 TNF PMC7378668__F6 Genes and processes involved in the 04660.T cell receptor signalling pathway ZAP70 CD48 LAT CTLA4 DAO ICOS CBL FYN BCL10 ITK GRB2 LCK CDK4 PMC7378668__F5 Genes and processes involved in the 04145.Phagosome pathway HEL-S-99n RILP TLR4 VAMP3 STX18 CD14 MARCO TUBB EEA1 M6PR CD6 MPO PMC6953314__F3 Intracellular signaling pathways of CAP, SNS, and HPA axis for anti-inflammatory responses STAT3 TLR4 FGF21 IRAK2 TLR7 TRAF6 IRAK4 MYD88 PMC9607206__F6 Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus MAVS TLR3 TLR8 IRF3 IRF7 TLR7 TRAF3 IRF8 TRAF6 MYD88 PMC8227550__F3 RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune Signaling TBK1 MAVS NLRP3 IRF3 IRF7 PMC6370374__F6 Molecular mechanism underlying LINC01133 regulated pancreatic cancer progression DKK1 GSK3B WNT1 EZH2 CTNNB1 PMC6126176__F4 miRNA-risk genes-pathways regulation network CSRNP3 LTA ZKSCAN1 PCMTD2 TNPO1 INTU SAMD13 PRR14L KRTAP2-4 MARCKS SHISA2 MEIS1 F8 ZMPSTE24 ZEB2 ZNF17 ZNF257 TMEM170A RGS8 TOX3 CAND1 BRWD1 MANEA ATG12 FAS ACBD3 PTEN MTSS1 SNRPC GABBR2 PSMA2 MAP2 TACSTD2 TEAD4 RAB21 CTCF PRKCE LETMD1 TMEM218 AGA PPM1B NACC2 SAMD12 ACRV1 KLF15 MRC1 GNRHR ZRANB2 PALMD RAB32 GHITM PMC6126176__F6 miRNA-core gene-risk signaling pathway regulation network TJP1 JMJD1C CAB39 F2R CDKN1B AKT3 BDNF APAF1 PMC5696061__F2 Rethinking HSF1 in stress, development and organismal health FBXW7 IGF1 EDC4 HSF1 MTOR SIRT1 PMC5595345__F8 Deregulation of KSHV latency conformation by ER-stress and caspase-dependent RAD21-cleavage RAD21 CTCF SMC3 PMC6614345__F2 Differentially expressed miRNAs in thyroid cancer tissues modulating the PI3K pathway ST8SIA4 PTEN GRB2 MIF MTOR PMC6224293__F1 Pathways involved in the synthesis of the main glycerolipids present in Arabidopsis mitochondrial membranes PGP PSD PC PMC9016027__F1 Synaptic or Non-synaptic? Different Intercellular Interactions with Retinal Ganglion Cells in Optic Nerve Regeneration SEMA3A OMG NRP1 LINGO1 ARHA PMC6614345__F1 Differentially expressed miRNAs in thyroid cancer tissues modulating the MAPK pathway RAF1 SOS1 EGFR BRAF ERBB2 GRB2 PMC9513225__F1 Implication of non-coding RNA-mediated ROCK1 regulation in various diseases CDH2 STAT3 HEL-S-36 PCNA MMP2 PTEN PMC11958968__F11 DSF against renal fibrosis via inhibition of PIK3/Akt/mTOR signaling pathway CDH2 SMAD4 PTEN MTOR PMC10311035__F1 Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders APC LRP5 RYK ARHA CTNNB1 PMC11513202__F2 Relationships between DNA methylation and hepatocellular carcinoma (HCC) proliferation, apoptosis and angiogenesis CASP8 MDM2 CCND1 CDK4 PMC5979509__F4 VEGFR2 signal transduction and trafficking pathways mediated by VEGF-A BAD SHB SRC PMC2742684__F1 Key signaling pathways between amino acids, inflammatory cytokines, and tumor-specific factors gr1Amino acids stimulate muscle protein synthesis through the mTOR pathway MYOD1 ELF2 MTOR EIF4E PMC5686903__F2 Over-expressed genes of Basal-like samples in p53 signaling pathway RFWD2 CASP9 ATR FAS SIAH1 PERP PTEN MYC TSC2 CASP3 CDK2 ATM MDM2 CDK4 PMC6687952__F7 Pathway convergence of proteins encoded by both ASD DMRs BAD CYP2E1 IGF1R GRB2 MTOR PMC8573085__F1 Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease LPL FAS NR1C1 CD36 PMC8258105__F1 Severe Clinical Worsening in COVID-19 and Potential Mechanisms of Immune-Enhanced Disease TMPRSS2 FCN1 SYK IL10 CCL3 TLR9 IL6 TNF CXCL10 CCL2 CCL4 ACE2 CARD9 PMC9278015__F4 Significance of interferon signaling based on mRNA-microRNA integration and plasma protein analyses in critically ill COVID-19 patients FITM2 PMC8961531__F3 Neurobiological and Pharmacological Perspectives of D3 Receptors in Parkinson’s Disease PDYN ARC MTOR BDNF PMC11945619__F6 Principal component analysis (PCA) of growth and development indices and related genes in the liver tissue of Rana zhenhaiensis tadpoles after exposure to polypropylene (PP) and polystyrene (PS) ACLY HSD17B4 PYCARD GPX4 PIK3R2 ZNRF2 FAM120C SLC39A9 NR1C2 PRDX3 BNIP2 DGAT2 HEL-S-2a BAG6 PKLR ACHE ACSF2 ABCB11 HEL-S-67p FABP4 PTGS2 DEPTOR ACACB SDHA SDHB HEL-S-162eP IFNAR2 IKBKB CASP3 APOB IKBIP PMC11551650__F3 MET oncogenic activation TPR HEL-S-61 CBL HGF HLA-DRB1 PMC11551650__F6 C-MET pathway relays downstream signals to activate multiple oncogenic events to promote cell proliferation, migration, protein synthesis, and antiapoptosis STAT3 BAD HGF MDM2 GRB2 MTOR PMC4750502__F5 Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism CYP51A1 NPAS2 CYP8B1 EBP SQLE CRY1 SC5D DHCR24 FAXDC2 NCOA1 ELOVL5 PROX1 DHCR7 GCK FDFT1 HSD17B7 TM7SF2 PMC11551650__F4 Hepatocyte growth factor/c-Met axis activates the Hedgehog pathway through downstream signaling STAT3 HGF HHIP KIF7 SUFU SMO GRB2 MTOR CCND1 GLI3 PMC4387238__F2 Signals for the lysosome: a control center for cellular clearance and energy metabolism RHEB MLST8 NR1C1 TFEB FES DEPTOR PMC11513202__F7 Pivotal role of DNA methyltransferase in DNA methylation and HCC progression DNMT3B LHX9 PANX2 HGF RASSF1 CDKL2 EZH2 MYOCD MTOR GATA4 PMC11513202__F4 Relationships between DNA methylation and sorafenib resistance in HCC CYP1A2 STAT3 TET2 MORC2 BNIP3 BNIP3L HDAC11 NF2 HDAC2 PMC11513202__F3 Relationships between DNA methylation and adhesion, invasion and metastasis of HCC TIMP3 EGFR PLG EMX1 MMP3 CDH15 PMC12113536__F1 Aberrant pathways induced by SMARCB1 deficiency and corresponding therapeutic targets ME3 AURKA CDK6 HMGCR MTOR MYC CDK4 PMC7464394__F3 Glutamatergic synapse pathway and expression levels of sea lice exposed to three drugs MAX GLS ACD PMC9561277__F8 APE1 assembles biomolecular condensates to promote the ATR–Chk1 DNA damage response in nucleolus TOPBP1 ATR ATRIP ETAA1 SSB PMC12206236__F1 Defining quality of cancer is cell cycle dysregulation, which results in uncontrolled cell growth and tumor formation CDC2 CDK6 CDK2 CDK4 PMC3943797__F1 Coagulation, Protease Activated Receptors and Viral Myocarditis TF TLR3 PMC6923859__F4 Regulation of immune response as the most relevant pathway in the infested susceptible (S) skin APOC2 STAT3 APOC1 TIMP1 OSM SERPINA3 LIF SOCS3 CCL2 RAC1 HRAS GRB2 JAK1 TYK2 PMC8882872__F3 Aryl Hydrocarbon Receptor Mechanisms Affecting Chronic Kidney Disease TGFBI IDO1 NAMPT AHR ACE2 PMC3141633__F3 Genes identified in the TGF beta pathway LTB IFNG FST FRK HEL-S-69p PMC8410789__F8 Working model of Alpha-KG-induced pyroptosis CASP8 GSDMC HEL-S-32 PMC5073228__F2 Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping AMD1 MDH2 PMC5500651__F5 Schematic illustration for signaling pathways of skeletal muscle growth regulated by let-7b IGF2BP3 GHR IGF2 PMC6198234__F5 Proposed mechanisms by which PKM2‐mTORC1 regulatory pathways contribute to resistance in RCC cells RICTOR PTEN MTOR PMC2928803__F3 Gene Expression Model for the Preferential Galactose Uptake in Yeast Cells GAL KY PC PMC12113536__F2 Summary of the role of SMARCB1 deficiency as a driver of the hallmarks of cancer in RTs HAVCR2 CLEC9A PRF1 EGFR CXCL10 PMC7549391__F2 Metabolic Messengers: ceramides CERS3 CERS5 CD36 ADIPOR1 CERS1 ADIPOR2 CERS2 KDSR MFF CERS6 PMC6148804__F1 Pictorial representation of un-inhibited Avian avulavirus 1 (APMV-1)-induced type I interferon (IFN) response in waterfowl cells MAVS STAT2 IRF9 IRF3 TYK2 PMC5433957__F2 Mechanisms of GPC3 in acute lung injury ATF2 GPC3 CTNNB1 PMC5433957__F1 Positive and negative effects of GPC3 on its two main signaling pathways STAT1 JUN KIF7 SUFU SMAD4 ATF2 GPC3 CTNNB1 GLI3 PMC5362412__F9 Probing the prostate tumour microenvironment I: impact of glucose deprivation on a cell model of prostate cancer progression ACO2 OGDH HEL-S-162eP HEL-S-30 PMC9405053__F2 Celastrol: A Promising Agent Fighting against Cardiovascular Diseases HMOX1 GSK3B CTNNB1 PMC9405053__F1 Celastrol: A Promising Agent Fighting against Cardiovascular Diseases GAL NLRP3 TLR3 HSF1 ABCA1 PMC6172959__F7 Poxviruses evade cytosolic sensing through disruption of an mTORC1-mTORC2 regulatory circuit TBK1 CGAS RICTOR IRF3 PMC2566927__F2 Essence of retrograde signaling in model organisms MKS1 AAMP CDK2 PMC6728679__F5 Sketch map of the Wnt5a/Ror2 signaling pathway in bone marrow stromal cells (BMSCs) that derives osteoclast precursor migration and differentiation CXCL12 ROR2 CXCR4 PMC6307990__F7 The proposed model is a graphical representation of the mechanism of interaction of IDO1 and IL6/STAT3/PD-L1 in EMT regulation in bladder tumor cells STAT3 IDO1 IL6 PMC6669485__F9 Summary diagram of signaling pathway of this study BAX ATR KEAP1 PMC2234434__F3 Genes involved in apoptotic pathways were altered in type II cells isolated from Stat3Δ/Δ mice SAT2 TPR CRK CAST BAD NTF3 CFD APP PTEN ATF2 CHAD FANCC PMC7084654__F6 Hypothetical alterations of the metabolic pathways for ATP production in low-oxygen stress response PDC TNR PMC4160991__F1 Schematic diagrams of DA dynamics and signaling in (A) Drosophila cuticle, (B) Drosophila brain, and (C) mammalian brain TH AANAT DDC PMC7248557__F1 TLR4 Signaling pathway TIRAP TLR4 IRF3 IRAK2 TRAF3 TRAF6 LBP IRAK4 MYD88 PMC154144__F2 Canonic Wnt signaling pathway molecules can induce a similar phenotype WNT10B APC CTNNB1 PMC6026738__F7 Hypothesis model LTBR CXCL13 CXCR5 BCL6 PMC9380290__F1 Mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets BAX APC LRP5 BCL2 ATM PTEN MTOR CTNNB1 PMC12138372__F2 Cellular mechanisms of hormones and their effect on bone maintenance ALPL SOST BMP2 BCL2 NFATC1 RUNX2 PMC4954455__F6 Working model of the molecular mechanisms of HDACi (e.g., abexinostat) on human skeletal (mesenchymal) stem cell differentiation into adipocytes and osteoblasts KLF15 CEBPA ALPL COL1A1 MSC VCAM1 CTNNB1 PMC5341237__F1 Diagram showing key components of the IL‐6 signal transduction pathway that could account for lipogenic gene expression in hepatocytes STAT3 FAS SOCS3 PMC6027159__F7 TNF-R1 signaling pathway SHARPIN MAP3K7IP1 TRADD ITCH OTULIN TAB3 TNF CYLD TRAF2 PMC8605459__F1 Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence CYP1A2 TH KLF6 AHR AHRR IL6 PMC6027159__F9 Nod1/2 signaling pathway SHARPIN MAP3K7IP1 RIPK2 TAB3 NOD2 PMC3488630__F2 Proposed model of HER2/3 signaling in epithelial cells NRG1 ADAM17 IL1B PMC6027159__F8 IL-1BR1 signaling pathway SHARPIN MAP3K7IP1 TIRAP TAB3 IRAK1 TRAF6 IL1B MYD88 PMC8016646__F2 Promotion, composition and intracellular activation of the VEGF‐VEGFR signalling pathway VEGFB VEGFC BAD FYN SHB VEGFD MTOR VEGFA SRC PMC8538279__F5 Microbiomics in Collusion with the Nervous System in Carcinogenesis: Diagnosis, Pathogenesis and Treatment STAT3 BDNF PMC8016646__F1 FGF‐FGFR signalling pathway FRS2 FGFRL1 GRB2 MTOR PMC12106324__F5 Canonical TGFB signaling via Smad signaling pathway SMURF1 SMAD6 SMAD4 SMURF2 PMC4382841__F5 Proposed model of novel roles of AQP3 and AQP5 in tumor biology AQP3 EGFR MTOR SRC CCND1 PMC4382841__F4 Proposed model of novel role of AQP1 in tumor biology EGFR ARHA AQP1 PMC2682028__F9 Changes in metabolism in Prx1-Cre; PORlox/lox limb bud cells and levels of cholesterol ACLY LOX ACAT2 MVD FDPS PMC3881294__F2 Regulating intestinal function to reduce atherogenic lipoproteins LPA MGAT1 DGAT1 DGAT2 MGAT3 MGAT2 PC PMC9774615__F1 Predicting and Understanding the Pathology of Single Nucleotide Variants in Human COQ Genes COQ10B COQ10A FDX2 COQ7 FDXR PDSS1 COQ4 COQ3 COQ2 COQ9 COQ6 COQ5 COQ8A IPP FDX1 PMC2248159__F2 A part of the yeast cell cycle pathway available from KEGG [26] GML CDC20 FAR1 CDC6 CLN3 CHN1 PMC3010754__F2 Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors CYP2B6 CYP3A4 PMC12095689__F4 Cotadutide enhances hepatic insulin-stimulated signaling pathways in DIO mice RPS6 GYS2 LARP1 PIK3C2A PTEN DEPTOR IRS1 MLST8 TSC2 PYGL TSC1 INSR PPP1R3G GRB2 CP PMC7937695__F1 Three kinds of inflammasome pathways associated with pyroptosis GSDMD DFNA5 FADD PMC9423707__F2 Anoikis resistance in diffuse glioma: The potential therapeutic targets in the future STAT3 TMEM43 LATS2 BAD EGFR IGFBP2 CTNNB1 PMC5260888__F7 Role of RIPK1 in ConA hepatitis model TRADD RIPK1 TRAF2 PMC7937695__F2 Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease GSDMD TXNIP TLR4 SIRT1 PMC4112623__F2 Cancer related pathways and processes that input into the Hippo pathway LATS1 SHH NF2 MTOR PMC4112623__F1 The core Hippo signaling pathway in Drosophila and humans LATS1 MOB1A MOBKL1A LATS2 TEAD2 TEAD3 NF2 TEAD4 PMC5659038__F5 Relationship between lipids and hedgehog signaling GPR161 CAMKK2 SHH SMO PMC9598289__F13 Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H2O2-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway STAT3 FYN KEAP1 GSK3B MAF MTOR PMC2405801__F2 Description of possible involved signalling pathways CDC42 EGF EGFR ATF2 GRB2 RAC1 PMC6008986__F1 Kynurenic acid (KA) is the product of kynurenine pathway, the central metabolite of the tryptophan metabolism KYAT3 KYNU KMO OPN3 PMC8013977__F6 IL-15–PI3K–AKT-mTOR signaling for NK cell development TSC1 FOXO1 PTEN GATA3 PMC8013977__F5 IL-15-JAK-STAT5 signaling for NK cell development JAK3 SOCS2 SOCS3 VEGFA PMC7248557__F4 Alteration of TLR4 signaling in pregnancy disorders TLR4 IRF3 TRAF3 MYD88 PMC10897999__F1 Roles of circRNAs involving interaction with RBPs or other proteins in GC EIF4EBP3 CD44 NR2A1 AGO2 MAP4K1 IGF2BP3 SLC2A4 PCBP1 SLC7A5 CNBP GPX1 NOTCH1 PMC6970631__F1 Key CSC signalling pathways Notch, Wnt, and Hedgehog DLL4 APC GSK3B DLL3 CTNNB1 PMC10897999__F3 CircRNAs work as translational templates to contribute to the proliferation and progression of GC MAPK1 RBX1 HEL-S-2a APC MTOR SET PARP1 PMC6970631__F3 Key CSC signalling pathways TGFB, JAK/STAT3, and NfKB STAT3 ADK ADA PMC6923785__F1 Mechanisms of resistance to PI3K inhibitors in estrogen receptor (ER)-positive breast cancer and current and future drug combination strategies involving PI3K inhibitors CDK6 EGFR PTEN MTOR CDK4 PMC3980897__F1 Dual-view setup of the enRoute visualization technique ARAF HRAS SOST EGFR NRAS GRB2 KRAS PMC3285457__F6 Smad7 is Inactivated through a Direct Physical Interaction with the LIM Protein Hic-5/ARA55 SMAD2 PMC2247392__F2 Growth factors trigger local and long distance signalling NGF EGFR BAP1 MAPK3 PMC6190593__F2 Immunity in Drosophila melanogaster — from microbial recognition to whole- organism physiology GAA ATF2 FADD MYD88 PMC7553635__F6 Activating Wnt and inhibiting Hippo pathway by cytosolic PWP1 LATS1 PWP1 MMP7 DVL2 TCF4 CCND1 CTNNB1 PMC3659569__F2 Ginseng and Diabetes: The Evidences from In Vitro, Animal and Human Studies FAS FOXO1 CRTC2 PMC6446989__F2 Biliary tract cancers: current knowledge, clinical candidates and future challenges TET2 EGF EGFR INA APC BRAF MTOR NOTCH2 CTNNB1 FGFR2 OMP NOTCH3 NOTCH1 ERAS PMC9099918__F1 Novel Therapeutic Approaches with DNA Damage Response Inhibitors for Melanoma Treatment CDC2 ATR ATRIP H2AX WEE1 CDK2 ATM SSB PMC6826129__F7 Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) as a central mediator of vascular aging CEACAM1 NOX4 TGFBR1 PMC6015651__F1 Domains and functions of MCPyV T antigens MAX RFC1 TLR9 MYCL MYC EIF4E PMC2976970__F3 Protein-protein interaction map of Notch transcription modifiers MYB UPF2 MED17 SMG1 SIN3A RPL6 RPL19 CDK8 DMAP1 HEPH TTK RPS17 RPS9 CDK9 PMC4875723__F6 Systematic model of the Hippo/YAP signaling pathway affecting cytotoxic drug resistance in osteosarcoma cells LATS1 LATS2 PMC12141490__F9 Neural controlled tear secretion from lacrimal gland UCP2 NTS LPO ADRA1A PMC9640682__F4 MiR-27a as a diagnostic biomarker and potential therapeutic target in systemic sclerosis CDH2 STAT3 HGF IGF1 SMAD2 SMAD4 HEL-S-28 GRB2 TRAF6 CTNNB1 PMC5803335__F3 Cytoplasmic APC and the WNT signaling pathway APC GSK3B GPR49 CTNNB1 PMC10987773__F5 Hepatic protein and amino acid metabolic pathway during pregnancy RPS6KB1 NFE2L2 PMC7972934__F7 Mechanistic illumination of the inhibitory role of VB in GBMVB promotes the expression of miR-7-5p in GBM cells and facilitates the delivery of miR-7-5p by exosomes to recipient GBM cells CDH2 BAX PCNA EGFR MMP9 PMC10987773__F4 Hepatic lipid metabolic pathway during pregnancy TG NR1C1 ANGPTL4 INSR CYP7A1 APOB PMC10987773__F3 Hepatic glucose metabolic pathway during pregnancy ANGPTL4 INSR SLC2A4 SLC2A2 IRS1 PMC4288710__F7 Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms LCP2 PLAUR CD14 PXK CXCR4 PMC8799556__F6 Integrin-linked kinase (ILK): the known vs. the unknown and perspectives CDC42 FAS RICTOR ILKAP HEL-S-28 RAC1 PMC11899901__F4 KEGG pathway map showing the differentially spliced genes within the adrenergic signaling pathway in the heart GNAS SCN1B RYR2 PLN TNC CACNA1C HEL-S-273 CACNA2D1 MYL2 ADCY6 PMC8064971__F2 Targeting protein-protein interaction interfaces in COVID-19 drug discovery TMPRSS2 HEL-S-69p FURIN ACE2 PMC11903262__F2 Protective role of Trem2 in different models of myocardial injury TREM2 SYK IL10 PMC3010754__F1 Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors CYP1A2 CYP2A6 CYP2B6 CYP2C9 PMC8562402__F1 Therapeutic effect of oxygen-ozone in controlling of COVID-19 disease CRP NLRP3 KEAP1 PMC8750298__F3 Blood–Brain Barrier, an Evolving Concept Based on Technological Advances and Cell–Cell Communications RECK LRP5 LRP6 PMC9319012__F11 RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection OGG1 GNPNAT1 PGM3 RELA GFPT1 PMC4546481__F4 Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth STAT1 COL6A1 PMC5729307__F2 Pathway signalling starts with the binding of insulin or growth factors to insulin receptors RHEB PTEN PMC8037405__F2 Key regulators and genetic pathways of phase transition from SAM to IM in cereal crops EHD2 ID1 EHD1 PMC9075957__F3 Interacting genes form a diet-responsive network affecting adipogenesis SRGN NNAT TNFRSF11A HEXB HMGCR F2R EBP CDKN1C PMC4685486__F3 Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases NLRP3 TLR9 AIM2 IL1B PMC8635032__F1 Recent Progress of Ferroptosis in Lung Diseases STAT3 FTH1 GPX4 NQO1 LPCAT3 BAP1 FACL4 PMC8706767__F2 NF‐KB signaling in inflammation and cancer TBK1 TRADD RELB TAB3 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 BCL10 OTUD7B TRAF2 CYLD PMC3901146__F1 Regulation of cellular stress-induced cell death pathways by IAPs NAIP CASP9 SMS CASP3 FADD PMC3901146__F3 Role of IAPs in DNA damage response ATM MDM2 TRAF6 FADD PMC7438569__F5 Cardioprotection from NAD+ repletion SIRT7 NAMPT GATA4 SIRT1 PARP1 PMC7438569__F1 NAD+ metabolism in the heart NMNAT1 NAMPT NMNAT2 NMNAT3 PMC2861866__F3 Hypothetical model linking multiple biological pathways in the development of SS-like disease based on differentially expressed genes identified in lacrimal glands by global microarray analyses STAT3 CXCL12 STAT1 COL1A2 APOD RAF1 CTSH APOE B2M CTSS PMC3328908__F10 Diagram of canonical actin cytoskeleton signaling pathway CRK EGF APC DAP PMC5753157__F1 T-helper responses to A IFNG TH STAT3 IL33 AHR CTLA4 GATA3 PMC3497295__F1 Selected signaling pathways in renal cell carcinoma (RCC) RHEB EGF EPO APAF1 VHL PMC6384818__F6 NOD1 and TLR4 signaling pathways and the main target of CBN in the suppression of LPS-induced inflammation TLR4 CXCL1 NOD1 IL1B MYD88 PMC10373067__F2 Bispecific antibody targeting TGFB and PD-L1 for synergistic cancer immunotherapy TGFBR2 SMAD2 TGFBR3 SMAD4 FURIN TGFBR1 PMC12125911__F7 Schematic diagram of VWA1 and Rac2’s roles in condylar cartilage under mechanical stress ACAN VWA1 FGF9 ADAMTS5 BCL2 FGFR3 PMC3296807__F1 Oncogenes and tumor suppressors associated with the regulation of autophagy RHEB MLST8 BAX TSC2 BAD TSC1 BNIP3 PTEN MTOR PMC6335350__F2 Therapeutic approaches in Alzheimer's disease: GSK3 Inactivation therapy: Neuroprotective compounds such as curcumin modulates PI3K/Akt/GSK3B pathway, leading to inactivation of tau hyperphosphorylation MTOR SIRT1 PMC6028070__F1 Cytokine signaling and their major negative regulators TRADD JAK1 TNF TRAF2 FADD PMC6335350__F1 Interplay between mTOR, AB and Tau in Alzheimer's disease RHEB TSC2 CDK5 TSC1 MTOR IRS1 EIF4E PMC4463992__F3 Most possible acting pathway of p42.3 protein by optimization of Bayes theorem HEL-S-43 S100A2 RHO CENPB VHL PMC7969667__F10 Schematic model of RipA depicting possible interaction of RipA with surface immune receptor TLR4 and emanating downstream cascades TH SDHA TIRAP TLR4 MDM2 TRAF6 TNF PMC7662708__F5 Kynurenine Induces Osteoclastogenesis Via the AhR Signaling Pathway AHR NFATC1 CYP1B1 PMC7170981__F5 Evaluation of genes regulated by butyrate in controls and patients with UC CD80 PIK3CA TIRAP CCR5 TNFRSF1A TLR9 CCL5 CCL2 TRAF6 CXCL8 STAT1 IL1R1 HLA-E NLRP3 TICAM1 IL18 RIPK1 IL2 FOXP3 MAP2K3 BIRC3 IL10 CSF2 TLR5 CD40LG IRF3 IL1A IL6 CXCL10 RORC NFKB1 RELA IKBKB PMC8280132__F3 System biology approach based on metabolic biomarkers and protein–protein interactions for identifying pathways underlying schizophrenia and bipolar disorder GLUD1 ABAT HEL-S-8a PIG59 GLS GAD1 GFPT1 PMC4463992__F2 Primary regulatory networks HEL-S-43 SP1 S100A2 RHO CENPB VHL PMC5474285__F1 Workflow: network analysis, relevant organ location network analysis, gene ontology, and pathway analysis were performed on active compounds identified in Pulsatillae Radix (PR) by screening and target fishing LPA MPL BAX BAD APC PMC5474285__F5 Network pathway: pathway enrichment analysis was performed STAT3 TLR4 APC NOD2 PMC7814589__F6 Signaling pathways regulating short stature in the Debao pony MMP25 TRH ALPL TSHR SOX11 COL9A1 SOX2 GHRH IHH MMP9 COL2A1 MYD88 TNFSF14 IGF1 SOX9 INSR PLCB2 COL9A2 GHR SOX5 PMC8066113__F2 Interactions between proteins, cells, and lentiviral infection for the GIMAP2 gene in PBNCs, as analyzed by the Pathway Studio program hIAN7 IL7R IL7 HIMAP2 PMC7535138__F2 Intracellular signal transduction of adipokines and insulin resistance STAT3 LEPR SOCS3 IRS1 PMC4129373__F1 Schematic cartoon of TLR signaling pathways TBK1 CD36 MAL TLR9 CD14 TLR5 IRF3 IRF7 TRAF3 TRAF6 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 TLR10 LBP PMC9029125__F2 Impact of Treadmill Interval Running on the Appearance of Zinc Finger Protein FHL2 in Bone Marrow Cells in a Rat Model: A Pilot Study SP1 KLF8 FHL2 SRC RUNX2 PMC4900422__F1 Constitutive CBM signaling in B- and T-cell malignancies ICOS CD79B LIMA1 CD79A BCL10 BCR PMC7744297__F2 AChR clustering and dispersal pathways MUSK CRK LRP4 CDK5 CRKL PMC7744297__F4 Simplified representation of the AChR pentamer and the N-glycosylation pathway of proteins and CMS-related genes (red color) GMPPB ALG11 DPM2 RFT1 ALG2 GFPT1 ALG3 DPAGT1 DPM3 ALG5 ALG12 DOLK ALG6 ALG10 ALG13 DPM1 PMC6960179__F5 Molecular evidence of inflammatory response and resolution of inflammation during MAP infection KLF4 STAT3 NOS2 TNLG1B TRADD PDGFA IRAK2 MIF SOCS3 TRAF6 NLRC4 TLR4 IRAK3 TNIP2 NOD2 TRAF1 TRAF2 PMC8836182__F1 Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC TSC2 BAD TSC1 EGFR PTEN IGF1R ABCG2 CTNNB1 PMC3748035__F1 Dynamic regulation of P2X4 receptors in microglia IFNG C2 BDNF PMC7242206__F2 Possible targets of the androgen pathway for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylaxis and adjuvant therapy TMPRSS2 ACE2 PMC8836182__F2 Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC TCF4 LEF1 CTNNB1 PMC2641000__F4 Cell-Autonomous Requirement for Rx Function in the Mammalian Retina and Posterior Pituitary SIX3 OTX2 SOX2 PAX6 ZIC2 PMC8303665__F2 Trastuzumab Mechanism of Action; 20 Years of Research to Unravel a Dilemma EGFR PTEN GRB2 SRC PMC10178469__F2 Downstream signaling pathway of TLRs TLR3 TLR4 MAL TLR9 TLR8 TLR7 MYD88 PMC11754255__F2 Primary role process of CCL2 in fibrotic diseases ACKR2 CCL21 NOTCH3 CCL2 TNF ACE2 PMC5952217__F2 Kynurenine pathway is initiated by the oxidation of tryptophan via the enzymes IDO and TDO, with downstream catabolites having toxic, antioxidant and cell-protective activity IFNG HEL-S-92n KMO AHR IL6 CTNNB1 PMC11754255__F1 CCL2/CCR2 axis and its associated signaling pathways STAT3 CCR2 MTOR CCL2 PMC5952217__F1 A schematic illustrating some of the factors proposed to affect obesity and carcinogenesis IFNG STAT3 FAS AHR IL6 MTOR IL1B CTNNB1 PMC6269289__F1 A simplified diagram of sialic acid metabolism in human NANP GNE CMAS SLC17A5 NANS SLC35A1 PMC2741489__F5 Known components of the IFN signalling pathway and explanation of observed results HEL-S-11 ISX PMC6446705__F2 Pathways modulating NAD+ levels in mammals NNMT NRK NAPRT PARP1 PMC4546458__F7 CXCL16/CXCR6 chemokine signaling mediates breast cancer progression by pERK1/2-dependent mechanisms CXCR6 CXCL16 ARHA PMC2220082__F2 Rosilitazone stimulates NSCLC proliferation by affecting the Akt/mTOR pathway through PPARGamma-dependent and PPARGamma-independent mechanisms TSC2 PTEN MTOR PMC2153436__F4 Immune Response and Cell Cycle Networks CDC20 TNFSF8 C1R NEK2 CCNA2 PLK1 TRAF6 SPI1 TACC3 BIRC5 PRC1 SAA2 SPAG5 NF2 SRC CENPF RAD51 PSMB8 C1S ECT2 PLG CTLA4 TNF MASP1 MKI67 NR1C1 BRCA1 C2 C8A UHRF1 PMC11667047__F1 Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions SLC25A38 ABCB6 CPO FECH ABCB10 UROD UROS PMC4844852__F1 Environmental Exposures – The Missing Link in Immune Responses After Transplantation TF CYP1A2 AHR CYP1B1 CYP1A1 PMC11667047__F2 Molecular mechanisms underlying the physiological and pharmacological effects of 5-ALA (in the presence of Fe2+)The green line indicates positive regulation, the red line indicates inhibition, the dashed line represents indirect effects UCP2 BCR KEAP1 UCP1 IRS1 PMC8067556__F1 WW domain-containing oxidoreductase (WWOX) interaction partners and signaling pathways in the nervous system SMAD2 APC WWOX SMAD4 CTNNB1 PMC5837599__F3 Typical structure and content of exosomes CD81 CD9 CD63 PMC11106351__F9 Anti-hepatitis B virus mechanism of dopamine STAT1 DRD1 LHB ISG15 PMC4825016__F7 Proposed model for cross-talk of IGF1 and integrin signaling IGF1 IGF1R SRC PMC5099148__F1 Biosynthetic pathway of pharmaceutical terpenoids IDE CR1L AACS MVK PMC2775047__F1 TLR Mediated Immune Responses in the Urinary Tract TIRAP MAL CD14 TRAF6 MYD88 PMC7392886__F2 Development of immunothrombosis.Platelets activated by thrombin and or PICs initiate (PAR)–mediated signalling further increasing levels of PICs VWF and TF coupled with suppression of suppression of thrombomodulin TF TFPI PLG VTN PMC5028879__F1 NOD2 senses MDP and elicits immune responses RIPK2 ATG16L1 NOD2 TRAF6 PMC6530647__F4 Carbon monoxide controls metabolic homeostasis via the PERK-eIF2Alpha-ATF4-FGF21, SENS2, and REDD1 pathway FGF21 ATF4 EIF2A SESN2 PMC7759159__F1 NFKB activation is central to the acute respiratory RNA virus-induced cytokine storm TMPRSS2 BTK TRADD TLR3 TLR4 TLR8 IRF7 TLR7 VCAM1 ACE2 IRAK4 MYD88 PMC4782048__F7 Model depicting how AMPK regulates cell fate decisions through lysosome-dependent control of Wnt signaling SOX17 GSK3B TFEB MTOR CTNNB1 PMC9366225__F1 CXCR6-based immunotherapy in autoimmune, cancer and inflammatory infliction CXCR6 ADAM10 MTOR PMC8507548__F1 Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis STAT3 NLRP3 TLR4 CXCL5 IL8RB PMC5809980__F4 Diagram illustrates the dominating signaling pathways involving Sal- induced autophagy RHEB TSC2 TSC1 MTOR TRIB3 DEPTOR PMC5596442__F2 Two strategies for photoactivation of cell signaling pathways PI3 CRY2 PMC4661823__F3 ER stress sensors and Programmed Cell Death in animals ATF4 EIF2A TRAF2 PMC9365022__F5 Doxorubicin-Induced Cardiotoxicity May Be Alleviated by Bone Marrow Mesenchymal Stem Cell-Derived Exosomal lncRNA via Inhibiting Inflammation LIPI PERP ATM GLA SHE PMC4899745__F1 Efficient production of acetoin in Saccharomyces cerevisiae by disruption of 2,3-butanediol dehydrogenase and expression of NADH oxidase GPD2 BDH1 HEL-S-4 GPD1 PMC6237873__F5 LncRNA-mRNA interaction networks JUN BMP7 RHO PMC8231864__F1 Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles PTEN PMC5564566__F6 Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC) EGF JAK1 NOTCH3 HES1 PMC9266941__F1 Pathophysiology and Emerging Molecular Therapeutic Targets in Heterotopic Ossification SMAD1 DKFZp781O1323 SMAD2 BMP2 SMAD4 PMC5495797__F7 Differences and commonalities in TLR4- and FcERI-activated production of proinflammatory cytokines BCL10 LAT TLR4 TAB3 MAL TRAF6 TNF MYD88 PMC5722026__F1 PCP and SHH Signaling pathways KIF7 SUFU SMO PMC1698511__F3 PKR is an intermediary component in TLR signaling RIGI TIRAP TAB3 IRF3 IRF7 TRAF6 MYD88 PMC7699852__F1 Simplified representation of aryl hydrocarbon receptor (AhR) pathways AHR PAH CYP1A1 CTNNB1 PMC9076607__F2 OPG-related signaling pathways VWF GSK3B TRAF5 NFATC1 TRAF3 TRAF6 TRAF2 CTNNB1 PMC5329766__F2 Understanding the intersections between metabolism and cancer biology FH GLS PC DHODH PMC7699852__F4 Deleterious effects of aryl hydrocarbon receptor (AhR) activation in asthma TSLP AHR CXCL8 PMC10975298__F4 Signaling pathways against resistant cancer BAX BAD FAS EGFR GIP PTEN MMP9 MTOR KIF7 SUFU MMP2 CDK2 SMO NOTCH1 PMC5797591__F1 Schematic overview of the roles of the Notch pathway in CD8+ T cells and its application to immunotherapy IFNG DTX1 HES1 PMC5380330__F4 MicroRNA profiling of CD3+CD56+ cytokine-induced killer cells CSA2 PRF1 OSM LAT TNFSF6 TNFSF10 TNF PMC3665230__F6 Pathway members of insulin/Akt signalling, TGFB, wnt signalling and inflammatory pathways that were regulated by prednisolone in 3T3-L1 cells FZD5 EGR1 ID2 FZD2 CXCL5 MCL1 PTEN IL6 CXCL10 FZD4 GREM1 CCL7 FZD1 DKK2 LEF1 PMC10975298__F1 Mechanisms of drug resistance in cancer cells BAX PGP PTEN PMC7286536__F1 Insulin regulates glycolysis through both AKT-dependent and AKT-independent mechanisms BAD TXNIP HK2 HEL-S-162eP PTEN PMC9218457__F6 Exosomes Derived From Mesenchymal Stem Cells Pretreated With Ischemic Rat Heart Extracts Promote Angiogenesis via the Delivery of DMBT1 STAT3 GSK3B DMBT1 MSC IL22RA1 CTNNB1 PMC5541666__F1 Details from the STRING interaction diagrams within the global transcriptome profiles of Pink1-deficient mouse cerebellar tissue SLCO3A1 MAPK9 SVOP MAPK8 SLC45A4 CLMN ARHGEF39 MAPK14 STAT1 CCNE1 RAB3GAP2 HEL-S-1 POLD2 CYLD ZFAND5 KPNA1 MAPK1 LIMA1 NCK1 FZD2 GSKIP PTPRT IRF3 TRABD POLE4 GPSM1 ADCY3 POLE3 SNX16 LGI2 HSU53209 RNF128 MMP14 CREB3 FKRP PIK3R3 AKT3 ISY1 EXO5 IKBKG YTHDC1 MAP2K4 SEMA6D AHI-1 CHUK SEMA5A FZD1 CPSF6 PCF11 FLJ10842 KRAS RAC1 SRSF10 KCTD15 NFKBIA PMC2946555__F2 Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival LATS1 PMC6476910__F2 DAMPs exposure SNAP23 BAX PANX1 ROCK1 ATF4 EIF2A ATG5 PMC8905584__F10 To detect potential pathways and target genes in infantile Pompe patients using computational analysis CBL FER PXN APC STRC STX3A PMC7913036__F1 Iron cycle in the tumor microenvironment (TME) TF STAT3 LCN2 CD163 IL1B CP PMC3276621__F2 Pathways for the synthesis of glycerolipids and their subcellular localization PGS1 PGP PI3 CDS1 GPT2 PC FAT1 INS PSD2 PMC12108002__F2 Major signaling pathways and transcription factors in BMSCs GC BMP2 RUNX2 SKI CTNNB1 PMC5405066__F7 Hypothetical mechanism of action of BoNT/A is achieved through the modulation of TLR2 and SNARE proteins, and minocycline occurs through the modulation of p38 and MMP9 in glial cells IL10 IL16 TLR4 IL6 IL18BP PMC3391329__F3 Proteome coverage of the KEGG ‘Insulin Signaling’ pathway BAD FAS CR1L POC1A MTOR INS EIF4E RHEB TSC2 CBL INSR FOXO1 GRB2 PMC11977922__F1 Signaling mechanism of the canonical cGAS-STING pathway and its downstream effects in diseases TBK1 CGAS IRF3 PMC11977922__F2 Mechanisms by which lipid metabolism regulates the STING signalling pathway CGAS SMPDL3A PMC3180192__F2 TGFB pathway genes in iMYC cells ZFP36 STAT3 SMAD1 ROR2 HTRA1 TGFBR3 TGFBR1 BAMBI CTDSPL INHBA COL1A1 SERPINE2 RHOD MGP COL4A2 COL12A1 TNFRSF11B DCN PMC11977922__F4 Mechanism through which STING activation leads to insulin resistance JMJD8 TBK1 AIG1 PPP2R1B IRF3 PAX6 TNF IRS1 PMC7174681__F3 Effects of mTOR inhibition are shown CDK6 PTEN DEPTOR IRS1 CDK4 EIF4E PMC7174681__F2 Dashed lines indicate a decreased interaction between two components or a diminished function CDK6 PTEN DEPTOR IRS1 CDK4 EIF4E PMC5137585__F2 Diabetic cardiomyopathy: signaling defects and therapeutic approaches PTEN MTOR IRS1 PMC7174681__F1 ER, mTOR, and CDK4/6 pathways and their links are shown MLST8 CDK6 PTEN DEPTOR IRS1 CDK4 EIF4E PMC7797765__F1 Simplified overview of the complement pathway C6 C7 HEL-S-62p PMC3141028__F4 13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation ELL CIT PMC10743075__F10 n-3-PUFA administration decreased mRNA expression of pro-inflammatory cytokines, as documented in the TNF signaling pathway IL15 TF ALPI TRADD SELE MLKL LIF TRAIP TRAF3 TNF FOS NOD2 CASP3 FADD PMC3909817__F4 Potential mechanisms of TGF-Beta-induced upregulation of Nox4 gene expression SMAD2 NOX4 PMC7943311__F6 Signaling pathways critical for the roles and differentiation of Th9 cells and Treg cells in solid tumor CD40 FAS FOXO1 IL7 HIF1A FOXP3 MTOR PMC5325806__F2 Intersections of Post-Transcriptional Gene Regulatory Mechanisms with Intermediary Metabolism FOXO1 SFRS3 CIRBP HNRNPK SIRT1 PMC9482322__F7 Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma TF ACSS2 SCD ANXA2 FASN MTOR PMC7452942__F2 Soluble protein sensors built by means of bottom-up approaches TF FGFR1 PMC4999974__F7 PAC-1 enhances the apoptotic signal as induced by cytotoxins such as doxorubicin BAX CAD HEL-S-62p PMC7601316__F1 Tumor necrosis factorA (TNFA) downstream signaling pathway mediated by two TNFA receptors, TNFR1 and TNFR2, and by membrane form of TNFA (mTNFA) reverse signaling TRADD TRAF3 TRAF2 PMC3701226__F2 Signaling pathways triggered by TCR and CD28 engagement PLCG1 TSC1 RAF1 BCL10 EIF4E PMC5541666__F3 Systematic analysis of key factors in the mitochondria-associated innate immunity pathway, using acute starvation of human SH-SY5Y neuroblastoma cells to reveal the transcriptional regulation of stress responses and their dependence on PINK1 PINK1 MAVS TRADD MFN1 IFIT1 IFIT3 IFIT2 IRF3 IRF7 RSAD2 PMC8825370__F4 Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer NF1 ARHA GRB2 MTOR PMC8825370__F3 Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer BAX BAD TRADD ELF2 MEI1 TRAF2 FADD PMC7433817__F6 Schematic chart of drug sensitivity‐related genes in the current study with proposed interaction or regulatory pathway in ccRCC GNAS LRP10 CCNE1 AXL CTBP1 MDM2 ACRBP MTOR RET PMC8304139__F3 NFKB—An Important Player in Xenoestrogen Signaling in Immune Cells LTB SYK BCL10 BCR RELB PMC7118125__F3 Signaling networks in immunometabolism CAMKK2 ULK1 FNIP2 FLCN FNIP1 MFF CTNNB1 PMC11126125__F4 Immune response induced by DTMUV infection and its immune evasion TBK1 TRIM32 TRIM56 MAVS IRF3 PMC3185015__F9 RSPO1/Beta-Catenin Signaling Pathway Regulates Oogonia Differentiation and Entry into Meiosis in the Mouse Fetal Ovary FGF9 NANOS2 CTNNB1 RSPO1 PMC8369065__F1 Mycobacterium-Induced Th1, Helminths-Induced Th2 Cells and the Potential Vaccine Candidates for Allergic Asthma: Imitation of Natural Infection TLR4 APC PMC2699853__F1 Diabetes alters the expression of multiple genes of the TGFB pathway (left side of the panel) and BMPs pathway (right side) in rat retinal vessels CD44 IFNGR2 TIMP1 COX1 TXNIP BMPR1A SOAT1 ELK3 HOXC8 NOTCH1 MXI1 TGFBR1 PMC4643662__F2B Proposed signaling mechanisms of S100A8/A9 in pancreatic-cancer cells.S100A8/A9 could interact with RAGE, leading to the activation of MAP kinases and NF̃KB signaling TLR4 S100A8 MTOR S100A9 PMC4692127__F8 Downregulation of the Canonical WNT Signaling Pathway by TGFB1 Inhibits Photoreceptor Differentiation of Adult Human Müller Glia with Stem Cell Characteristics WNT5B IGF1 DKK1 WNT2B CTNNB1 PMC5220431__F4 The HH signaling pathway in lung cancer GRPR PRKCI SOX2 SMO PMC5220431__F2 HH signaling pathway during development BOC SUFU SMO GLI3 PMC8825370__F1 Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer EGF TLR4 BCL2 MTOR PMC3306451__F2 Integration of mitochondrial oxidative and antioxidant pathways by PGC-1A SIRT3 NR1C1 SIRT1 PMC8032984__F2 B7-H3 increases ROS and HIF-1A through B7-H3-induced Nrf2 suppression, SOD1, SOD2, and PRX3 reduction, thus promote aerobic glycolysis in cancer cells, leading to tumor growth TGFB1 APC MTOR HEL-S-44 PMC8536186__F6 Fractionated Seminal Plasma of Boar Ejaculates Analyzed by LC–MS/MS: Its Effects on Post-Thaw Semen Quality ST13 NUP107 NUP214 SEC23A MAPKAPK2 GNAL MEF2C AAAS ALB CRK DMWD CD74 ATM APP CSTA PMC2818238__F1 Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms CA4 PC PMC7226273__F5 Proposed mechanism for Vinorelbine’s radio sensitizing effect ATR ATM PMC8051751__F6 Molecular mechanisms induced by sirt1 inhibition in ACC cells CDH2 BAX IGF1R CCND1 PMC7774512__F3 Working hypothesis of Glial Molecular Mechanisms Implicated in the Pathogenesis of POI NR1C1 IL16 IL1B S100B PMC8063300__F1 Aryl hydrocarbon receptor in central nervous system tumors: Biological and therapeutic implications CSA2 NQO1 RELA RELB AIP AHR CYP1A1 PMC11687167__F4 Signaling pathways associated with PCSK9 during the immune response (created in https://BioRender PCSK9 TH STAT3 BAX STAT1 TLR4 STAT4 NFATC1 PMC7926563__F2 Therapeutic agents targeting the B-cell receptor (BCR) signaling pathway in follicular lymphoma SYK BCR LYN PMC9020237__F1 Emerging role of the itaconate-mediated rescue of cellular metabolic stress ATF3 SUCNR1 IL1B PMC8306340__F5 Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC TH RASSF2 LTA PSME4 NFKB2 IKBKE SPHK1 PSMA4 TRAF3 MAP3K14 HEL-S-276 IKBKG LITAF RPS3 COX2 IL18 CHUK CYLD PSMD7 PHB2 PSMD9 NFKB1 RELA IKBKB MAP3K7 EP300 VCAM1 TRAF2 EDAR TNLG7C PMC9006990__F2 Anti-EGFR Monoclonal Antibody in mCRC Maintenance Therapy EGF EGFR PTEN MTOR PMC1828869__F2 Regulation of induction and vesicle nucleation RHEB TSC2 TSC1 ATG14 PTEN PMC3889251__F9 New proposed model of BMP2-induced C2C12 cells differentiation BMP2 SMAD4 MTOR PMC9701395__F9 Computation and molecular pharmacology to trace the anti-rheumatoid activity of Angelicae Pubescentis Radix CDC42 CASP9 BAD COX2 SRC PMC5864196__F3 Potential metabolic capabilities MAL OTP CIT PMC2663056__F4 Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling MAX EGF CASP8 CASP3 TNF IRS1 PMC3889251__F1 BMP2 signaling pathway resulting in osteogenesis or adipogenesis TF MAP3K7IP1 BMPR1A BMP2 ATF2 PMC4089092__F1 Toll-like receptor (TLR) signaling pathway TLR4 CD14 TRAF6 MYD88 PMC7521272__F4 Pathway analysis of the differentially expressed proteins between the gastric cancer (T) and adjacent tissues (P) NDUFA12 COX10 NDUFB9 NDUFA6 UQCRQ NDUFAB1 NDUFA10 COX17 NDUFS3 NDUFA11 NDN ND6 NDUFS6 NDUFA3 UQCRC2 NDUFB7 UQCRH SI NDUFC2 ND4 SDHD SDHA SDHB CYB UQCRFS1 SDHC PMC10239510__F7 Paradigm summarizing the thermogenic and anti-inflammatory properties of YJT via the gut microbiota and related multiple signaling pathways TH GPR65 FFAR3 PGLYRP1 PCNA PRDM16 TRPV1 PGLYRP2 ADRB3 DIO1 TRPV3 CIDEA TLR4 NOD2 FFAR2 PMC2663056__F3 Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling EGF CASP8 TNF PMC4821196__F2 Summary of the intracellular signaling cascades that occur within neurons and glia within the brain VIT BAX JUN GSK3B MTOR BDNF SST PMC9322149__F4 Exploring Quercetin Anti-Osteoporosis Pharmacological Mechanisms with In Silico and In Vivo Models TRADD ITCH SELE CELA1 LIF HEL-S-11 TNF TRAF2 TNLG7C FADD PMC3758473__F5 The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease ATM MYC PMC10552637__F1 Metabolic cycle of tetrahydrofolate (THF) and the one-carbon (C1) metabolic pathway MTHFD2 MTHFD1 AMT MTHFD1L HEL-S-51e PMC2737697__F2 Genetic Susceptibility to Lupus: New Insights from fine mapping and genome-wide association studies CRP PTPN22 TNFAIP3 BCR HEL-S-62p TNFRSF4 STAT4 IRF7 TNLG2B PMC11903573__F2 HDACs and KATs that are involved in adipose tissue regulation HDAC1 FOXO1 PRDM16 USF1 UCP1 CIDEC PMC11903573__F3 KATs and HDACs play a role in glucose tolerance and insulin resistance HDAC3 SF1 FOXO1 TLR4 HDAC11 SIRT1 IRS1 SIRT6 HDAC6 PMC4796178__F1 Exercise-induced autophagy signaling TF TFEB BNIP3 MTOR SIRT1 PMC6838412__F7 Proposed mechanisms in SS MSG MAVS IRF3 IRF7 EIF4A2 DROSHA PMC4449431__F8 Schematic model illustrating the possible pathway targeting NCI-H929 cell by HM910 BAD CDK6 CCND1 CDK4 PMC9136877__F6 Unlocking the Untapped Potential of Endothelial Kinase and Phosphatase Involvement in Sepsis for Drug Treatment Design ANGPT1 AXL SRC RAC1 PMC3758473__F2 Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease PER2 CRY2 CRY1 FBXL3 PMC7668088__F9 Conceptual model of OR2W3-evoked ASM relaxation and bronchodilation OR2W3 ORAI1 INSR STIM1 CFTR PMC8107117__F5 YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance LATS1 LATS2 YAP1 PMC8201174__F3 Molecular Pathogenesis of Pulmonary Fibrosis, with Focus on Pathways Related to TGFB and the Ubiquitin-Proteasome Pathway SMAD2 SMAD4 SMURF2 SKP2 BLM NOX4 STUB1 PMC8345866__F8 Summary scheme for potential drugs to target the Wnt-AMPK-mTOR pathway during epileptogenesis PDK4 PORCN MTOR WNT8B SFRP1 FOXG1 CTNNB1 PMC6646331__F5 Glutamatergic synapse (path:hsa04724) pathway mapping of the protein targets of DPCs: The location of protein targets of DPCs in the KEGG pathway hsa04724 is represented in yellow and red coloured boxes, red ones are specific to mGluRs TH BAAT GLA ARG1 GLO1 PMC7402353__F3 13 major receptor groups involved in itch and their endogenous pruritogens TRPA1 ITCH TRPV1 PMC9409283__F2 Analysis of Amino Acids in the Roots of Tamarix ramosissima by Application of Exogenous Potassium (K+) under NaCl Stress TH ADM OCM PMC8336468__F7 Clostridium cellulovorans Proteomic Responses to Butanol Stress TH PMC5995146__F2 Parkinson’s disease: From human genetics to clinical trials VPS35 PINK1 LRRK2 FBXO7 SNCA PMC3926967__F2 Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections STAT3 IFNAR2 IFNAR1 JAK1 TYK2 IRS1 PMC9224161__F4 Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain GOT2 NR1C1 PDK4 HEL-S-133P HK2 PC HEL-S-32 MPC1 ME1 CPT2 PMC4454159__F2 Concept map of the cancer metabolic rewiring MTHFD2 HEL-S-133P PHGDH MAL GLA GLS2 HEL-S-51e CIT PMC3919979__F9 CNP action in the SRG GC CFTR CNP PMC7761947__F3 Signaling mechanisms for TRPM2 and TRPM8 activation TRPM2 IL16 TRPM8 PMC9326605__F1 DNA Hypomethylation May Contribute to Metabolic Recovery of Frozen Wood Frog Brains TET2 TET1 TET3 TDG PMC4454159__F1 Glutamine metabolic rewiring MAL GLS2 NNT CIT PMC4688904__F1 The glucocorticoid receptor, regulation of gene expression, and its clinical consequences POLR2A RORA PMC9224161__F2 Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain GOT2 NR1C1 PDK4 GLS HEL-S-133P HK2 PC HEL-S-32 MPC1 ME1 CPT2 PMC7761947__F2 TRPM1 role in visual pathways CAMKK2 TRPM1 MTOR MLSN2 PMC4102943__F6 The proposed point at which dFdC metabolism interacts with the Kennedy pathway that converts choline to phosphatidylcholine, resulting in formation of GdPC, and the impact of linoleate on that reaction CDA PMC7060963__F5 Transcriptomics and pathway analysis of CRISPLD1-KO-hiPSC-CM RYR2 L1CAM INA RHO TNF PMC11004819__F3 Pharmacogenomics-based systematic review of coronary artery disease based on personalized medicine procedure PDIA2 LPL APOC2 APOC3 APOC1 DGAT1 SQLE ABCA1 ACSS1 LIPC APOA4 ABCG8 ABCG5 MTTP HMGCR SCARB1 CYP7A1 LDLR SOAT1 APOB PLTP FDFT1 APOA5 PMC11530992__F1 Canonical pathway and non-canonical pathway of NFKB signaling pathway BCL10 BCR REL PMC4385749__F5 Diagram of the neural circuitry underlying delay eyeblink conditioning GC PC CS PMC6592230__F7 ATM/Chk/Greatwall/PP2A signaling model for normal mitotic exit (A) and for abnormal mitotic exit during recovery from mitotic DNA damage (B) CDC2 ENSA ATM PLK1 PMC6999766__F8 Schematic diagram summarizing the therapeutic effects of the flavonoid ingredients isolated from Abelmoschus manihot (L.) Medik flowers in multiple myeloma HK3 HK2 PMC4732610__F6 Transcriptional Analysis of T Cells Resident in Human Skin TF UGT1A3 SP1 GSTT2 JUNB MGST1 GPX3 CYP1A1 GPX1 FOS NOX4 MAOA MAPK14 HMOX1 NFKB1 GCLC TXN2 NFE2L2 MAPK10 XDH CYBA TXNRD2 HEL-S-44 HEL-75 PMC4732610__F5 Transcriptional Analysis of T Cells Resident in Human Skin IL15 TH IL10 TGFB1 CSF2 CSF1 IL13 IL3 CXCL1 IL4 CXCL2 TNF IL5 CSF3 IFNG HLA-DRA IL2 IL11 IFNB1 PMC2861286__F1 Proposed mechanism for vitamin D’s action on the innate immune system NR1i1 TLR1 PMC2908542__F8 Sirtuin 3, a New Target of PGC-1A, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis SIRT3 UCP1 GPX1 PMC8200410__F6 Ketogenic Metabolic Therapy, Without Chemo or Radiation, for the Long-Term Management of IDH1-Mutant Glioblastoma: An 80-Month Follow-Up Case Report OXCT1 ROS1 GOT2 HEL-S-133P PMC4908334__F5 SBGN representation of the haematopoiesis gene regulatory network generated by ChiBE () based on our BioPAX model GATA2 FLI1 GATA1 RUNX1 HHEX SMAD6 ZFPM1 ERG PMC11523104__F1 2–3% of glucose entering the cell is diverted from glycolysis into the hexosamine biosynthetic pathway (HBP) OGA OGT NAGK PMC5547388__F5 MicroRNA expression analysis in endometriotic serum treated mesenchymal stem cells EGF JUN BAD BTC GRB2 MTOR SHE NRG4 PMC7326927__F10 Summary of the effects of MPP+ and rotenone exposure on IL4-induced immune response on primary glial cell cultures PFKP CD200R1 IL4 HIF1A CD200 PMC4137222__F2 HBV interaction with the ER-associated degradation pathway EDEM3 EDEM1 EDEM2 PMC8891559__F2 Necroptosis in alcoholic liver disease and hepatic pathogenesis RIPK3 OGT HMGB1 CYP2E1 MLKL PSMC1 RIPK1 GLA PSMA2 PMC8891559__F1 Necroptosis in alcoholic liver disease and hepatic pathogenesis HMGB1 TRADD MLKL CXCL1 CXCL2 RIPK3 MAP3K7IP1 ZBP1 NLRP3 TLR3 TLR4 IFNAR1 RIPK1 PPM1B TRAF2 CYLD FADD PMC7307818__F7 Possible mechanisms responsible for the effects of paeonol against human colorectal cancer HCT116 cells CDK6 GSK3B AXIN1 CCND1 CDK4 CTNNB1 PMC6567800__F7 Anti-shock mechanisms of molecular hydrogen during sepsis TLR4 FGF21 GSK3B GHRL RHO RAC1 PMC12027419__F5 Identification of key players in burn injury-related REC network NAPEPLD ABHD6 FAAH PMC7423769__F4 Proposed network for BMP signaling in regulating energy metabolism via mTOR and HIF-1 BMP2 MSC BMP7 PMC6567800__F6 Anti-apoptosis mechanisms of molecular hydrogen in sepsis TLR4 GSK3B MYD88 PMC4944539__F1 FGF/FGFR signaling pathways FRS2 SOS1 GRB2 PMC5570368__F7 Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing PPARG JUN NR1C1 EP300 PMC5216813__F6 Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer CYP51A1 CYP8B1 CYP46A1 CYP7B1 CYP27A1 PMC8301600__F2 Alphaherpesvirus-mediated innate immune evasion TBK1 TLR1 CGAS PUS3 IFNAR1 AIM2 IFI16 IRF3 MYD88 PMC8966199__F8 Redox proteome analysis of auranofin exposed ovarian cancer cells (A2780) SVIP BAX SELL COPE F2 CASP12 SKP1 ATF4 ATP6 TRAF2 PMC2225983__F3 PI3K-AKT pathway is transcriptionally regulated throughout the lactation cycle RHEB BAD CDC37 MTOR PMC5570368__F8 Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing PPARG NR1C1 RXRA NR1C2 NR1A2 NR3C1 PMC8531217__F12 Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development TMPRSS2 ACE2 PMC5274707__F1 Neutrophil crosstalk with immune and humoral cells and relevant chemical signals that influence and compose the inflammatory response and pathway to resolution via the neutrophil CXCL9 TLR3 TLR4 TLR9 MPO PMC11751205__F5 Autophagy pathways in normal and burned tissues USP30 PINK1 MFN1 BNIP3 TOMM20 PMC8750666__F9 Building a Foundation for Precision Onco-Nutrition: Docosahexaenoic Acid and Breast Cancer RHEB RPS6 TSC2 EIF4B TSC1 INSR ULK1 PC RHO ELF3 IRS1 EIF4E PMC6580575__F4 Mechanistic diagram of NGF and ILM-mediated proliferation promotion by regulating cell cycle of Müller cells NGF CDK2 CCND1 CDK4 PMC8685280__F5 Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment TH LEP FOXP3 SET PMC3000610__F6 Proposed working hypothesis SPHK2 TLR4 SPHK1 SKI PMC9293537__F5 Pharmacological Approaches to Decelerate Aging: A Promising Path TSC1 GPX7 IRS1 PMC6212521__F8 Schemes of normoxic vs FH MAL GC CS PMC5693908__F1 Inflammatory signaling pathways in hematopoietic cells and potential therapeutic targets for myeloid malignancies STAT3 TRADD TIRAP STAT2 IRF9 ATF2 IL6 TRAF6 MYD88 IFNG IFNGR2 IFNAR2 TRAF2 PMC11379071__F8 Diagram illustrating the underlying molecular mechanism identified in the present study CNOT1 LATS2 YTHDF2 PSAT1 ATF4 METTL3 YAP1 PMC6212521__F7 Schemes of normoxic vs FH MAL CS PMC5523465__F1A Checks and Balances: the Glucocorticoid Receptor and NFKB in Good Times and Bad CORT FKBP5 FKBP4 NR3C1 PMC4480752__F7 miR-93 Promotes Cell Proliferation in Gliomas through Activation of PI3K/Akt Signaling Pathway PHLPP2 FOXO3A PTEN CCND1 PMC4701972__F2 Regulation of the Hippo pathway by upstream signals LATS1 CDC2 TAOK1 TAOK2 LATS2 TAOK3 RHO NF2 PMC6259838__F1 Cell cycle pathway represented in KEGG CDC2 STAG2 DBF4 PCNA CDC6 STAG1 SMAD2 SMC3 SMAD4 MYT1 ORC3 SKP2 RAD21 CDK7 E2F4 CDK2 PMC7038792__F1 NF2/merlin signaling and potential therapeutic targets in NF2 JUN LIN28B EPHA2 EGFR MYC CTNNB1 LATS1 RHEB CD44 TSC2 LATS2 TSC1 SRC CXCR4 PMC4571436__F2 CXCR3 Isoforms play functional roles in seemingly opposing directions CXCL9 STAT3 BACH1 MCL1 SOCS3 SRC PMC3558412__F1 Diagrammatic overview of the late stages of the HIV life-cycle ABCE1 TSG101 PMC7832464__F2 Progression of SARS-CoV-2 infection and inflammation FCN1 ADAM17 ACE2 IL1B PMC9709483__F2 Therapeutic potential of exosomes/miRNAs in polycystic ovary syndrome induced by the alteration of circadian rhythms PER2 NAMPT RORA PMC7927067__F9 STAT1 and STAT3 regulation of inflammation and growth arrest phenotypes in senescent preadipocytes STAT3 STAT1 CGAS MX2 ISG15 CXCL10 PMC6209233__F10 Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential BAD VASP FYN HEL-S-28 PTEN ARHA SHE PMC9641401__F5 Krüppel-like factor 6 splice variant 1 in the development, diagnosis, and possible treatment strategies for non-small cell lung cancer CDH2 BAX CCL24 KLF6 TWIST1 PMC6606851__F10 Summary of the dominant effects of WNT5A mutations on skeletal morphogenesis WNT3A CTNNB1 PMC3122626__F4 Key cellular signaling cascades regulating morphogenesis in C NRG1 LMO1 ACE2 RAC1 PMC5372601__F1 RAS/RAF/MEK aberrant signaling and mechanisms of resistance to inhibition in melanoma EGFR PTEN GRB2 MTOR PMC4699681__F1 Signaling pathways activated in chondrocytes by fibronectin fragments MMP10 LIF SRC PMC11608501__F11 Proposed schematic describes the mechanism of TRPM7-induced pyroptosis in SE STAT3 TRPM7 GSDMD NLRP3 PMC3122626__F9 The calcineurin signaling pathway in C CPA2 CPA1 MID1 HEL-S-84 FPR1 PMC8006187__F1 Network-based virus-host interaction prediction with application to SARS-CoV-2 GAL IRF3 ACE2 PMC3589914__F5 Regulatory circuits operating in osteoblast lineage cells DKFZp781O1323 BMP2 HDAC5 ATF4 RUNX2 PMC9386474__F1 Oncogenic signaling pathway-related long non-coding RNAs for predicting prognosis and immunotherapy response in breast cancer TGFA MYC SET PMC8201567__F8 Promotion effects of DEHP on hepatocellular carcinoma models: up-regulation of PD-L1 by activating the JAK2/STAT3 pathway STAT3 PMC2828057__F1 Genetic factors influencing cytarabine therapy CDA RRM1 RRM2 DCTD PMC6121884__F3 Akt/mTOR pathway in schizophrenia TSC2 NRG1 CDK5 TSC1 ERBB4 ULK1 MTOR DISC1 PMC7670535__F1 Role of AKAP13 in cardiac function MEF2C PMC9260392__F1 Targeting Novel Regulated Cell Death: Pyroptosis, Necroptosis, and Ferroptosis in Diabetic Retinopathy GSDMD NLRP3 IL1B PMC3693006__F4 Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells TIRAP TLR4 MAL TRAF6 MYD88 PMC7232694__F2 Adeno-Associated Virus Genome Interactions Important for Vector Production and Transduction RAD52 SP1 PCNA FKBP2 TLR9 SETDB1 YY1 POLN PMC3027599__F6 Ingenuity Pathway Analysis Network 2 depicting relationship among up-regulation Genes in SL1344 vs SB1117 infection groups at 8 hours ARHGAP26 RHOB RHOV PMC3027599__F5 Ingenuity pathway Analysis network 1 depicting relationships among up-regulated genes in SB300 infection group relative to that of SB1117 infection group at 8 hours PCSK9 LY96 SAA2 IRF4 PMAIP1 PMC5352145__F10 Genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel ROBO3 APRT CBL PDE1C GCLC RPL36 AAG1 EIF5B RPL6 PMC8608404__F4 Two models for coordination between TLS and DSB Repair by REV7 SHLD1 TRIP13 SHLD3 SHLD2 PMC8608404__F3 REV7 controls pathway choice at DSBs SHLD1 TRIP13 BRCA1 SHLD3 SHLD2 PMC5884111__F6 Cartoon schematic showing the mTOR signaling pathway in cells RHEB TSC2 TSC1 EGFR PTEN PMC8608404__F2 REV7 Controls Pathway Choice at Stalled Replication Forks TRIP13 REV1 PCNA PRIMPOL POLN PMC3216677__F1 Proposed estrogen receptor (ER)-activated signaling pathways involved in vasodilation TF EGF EGFR PMC3418323__F5 Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor FGF7A LIF TBX3 GRB2 JAK1 PMC3418323__F4 Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor STAT3 FGF7A LIF GSK3B PMC3418323__F2 Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor STAT3 LIF JAK1 PMC7214455__F1 Taking aim with IAP antagonists at triple-negative breast cancer: a moving target no more? RIPK3 CASP8 TRADD MLKL CASP3 RIPK1 TRAF2 FADD PMC8222712__F1 Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects CD44 CD1A ARG1 CCL5 MTOR HEL-S-87p MYC PMC6121884__F1 Mammalian target of rapamycin (mTOR) pathway TSC2 TSC1 ULK1 PTEN MTOR IRS1 PMC9446768__F1 Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases TH CIDEA UCP1 PMC8404464__F4 Network medicine in Cardiovascular Research PSMD3 IL10 PAH NEDD9 PMC3861374__F4 Mechanism of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) HGF EGFR PTEN IGF1R PMC5974615__F1 Regulatory Network of ARF in Cancer Development CDK6 MDM2 CDK4 PMC7947908__F5 Insights Into the Involvement of Circular RNAs in Autoimmune Diseases HEL-S-62p APC ATF2 PMC7947908__F4 Insights Into the Involvement of Circular RNAs in Autoimmune Diseases TNLG8A DERA CR1 PMC8222783__F4 Resistance Mutations to BTK Inhibitors Originate From the NFKB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway SYK CD79B CD79A CARD11 BRAF BLNK CD19 MTOR TRAF6 KRAS IRAK4 MYD88 BLK GNB1 BTK FYN BCL10 PLCG2 VPREB1 NRAS LYN PMC3726443__F6 Full Transcriptome Analysis of Early Dorsoventral Patterning in Zebrafish LRP6 GSC ZIC3 CTNNB1 PMC3983488__F1 Matricellular TSP1 via CD47 restricts NO-sGC-cGMP signaling CD36 SIRPA SRC CD47 PMC9464960__F3 MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives DGAT1 GLS KLF6 RELB CIDEC YY1 P4HA1 SIRT1 INSIG1 RORA PMC7284928__F2 Protein-protein connection networks among the eight genes involved in PPARG-MI signaling pathways PPARG RELA ACADM MYD88 PMC6880621__F2 NLRC5’s role in renal diseases TGFBI HK2 PMC9017576__F1 TXNIP: A Double-Edged Sword in Disease and Therapeutic Outlook NLRP3 TXNIP TNF CD6 PMC3493640__F1 Multi-omic map of the lipid-producing yeast Rhodosporidium toruloides IPP FAS ACO2 HK2 HEL-S-162eP IDI1 MDH2 ERG PMC3390194__F1 Personalized Medicine and Inhibition of EGFR Signaling in Lung Cancer EGF TGFA EGFR PTEN MTOR PMC4291046__F1 Convergent signaling pathways where inflammation and metabolic signaling intersect along the CHIEF pathway SOCS1 TSC2 IL10 TSC1 IKBKB SOCS2 IL4 PTEN IL6 MTOR TNF PMC5078108__F1 PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma RHEB BAX TSC2 BAD TSC1 GSK3B GIP PTEN MDM2 GRB2 PDK2 PMC6021761__F3 Discovery of IDO1 inhibitors: from bench to bedside IDO1 KYNU KMO AHR IDO2 PMC5660707__F5 Scheme of magnesium and calcium transporters and their interaction in the AD brain TRPM7 APP MTOR TRPM6 IL1B PMC11847631__F3 Expression of inflammatory mediators induced by pathogen invasion TLR4 CCL2 TNF MYD88 PMC5660707__F2 Model describing the copper transport system and its association with AD ATOX1 CCS GSK3B ATP7B COX17 ATP7A PMC5410960__F16 Top illustration shows disruptions in normal cell survival and normal apoptosis in glioblastoma EGF FAS EGFR MTOR PMC8222783__F3 Resistance Mutations to BTK Inhibitors Originate From the NFKB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway SYK CD79B CD79A CARD11 BRAF TLR9 BLNK CD19 MTOR TRAF6 KRAS IRAK4 MYD88 BLK GNB1 BTK FYN BCL10 BCR PLCG2 NRAS LYN PMC8684172__F2 Regulated cell death: discovery, features and implications for neurodegenerative diseases NLRC4 NLRP1 GSDMD NLRP3 AIM2 PMC8222783__F1 Resistance Mutations to BTK Inhibitors Originate From the NFKB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway SYK CD79B CD79A CARD11 BRAF TLR9 BLNK CD19 MTOR TRAF6 KRAS IRAK4 MYD88 BLK GNB1 BTK FYN BCL10 BCR PLCG2 NRAS LYN PMC5733868__F4 Path diagram of the nuclear factor kappa B (NFKB) signalling pathway EGF NGF LTA RELA RELB IL4 IL2 REL PMC4926490__F1 An illustration of the genesis of exosomal aquaporin-2 (AQP2) in renal collecting duct principal cells AQP4 AQP2 AQP3 AVP PMC4058194__F8 RTK/RAS/PI(3)K signaling pathway GRIA2 EGFR PTEN PMC6032173__F3 Regulatory mechanisms of selected modifications in PPARG DOK1 CDK5 CDK7 PER2 THRAP3 PRDM16 PPM1B CDK9 SIRT1 PMC5341000__F10 Proposed scheme for the role of male sex on energy metabolism in the diabetic kidney SET PMC8505728__F7 Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal Pathogen Cryptococcus neoformans THOP1 tmp_locus_29 MIF PMC8505728__F6 Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal Pathogen Cryptococcus neoformans CD226 CD40 TH CD80 CD2 CD36 APC CD22 PTPRC POLI CTLA4 CD96 SPN ICOS CD58 PTPRO tal-1 AGA POLE CD6 PMC8469949__F2 Actin Cytoskeleton Dynamics and Type I IFN-Mediated Immune Response: A Dangerous Liaison in Cancer? TBK1 MAVS NOD2 RNASEL IRF3 IRF7 RAC1 PMC4058194__F6 In mTOR signaling pathway, there is the triplet of genes codes for proteins (orange nodes), and the pair (ATM and TP53) corresponds to interacting proteins in the cell cycle pathway (light blue nodes) TSC2 STK11 TSC1 EGFR ATM MDM2 MTOR PMC8469949__F1 Actin Cytoskeleton Dynamics and Type I IFN-Mediated Immune Response: A Dangerous Liaison in Cancer? TBK1 STAT1 MAVS STAT2 IFNAR2 IFNAR1 IRF3 IRF7 JAK1 MYD88 PMC3411810__F6 BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines GSK3B PTEN PMC8869457__F1 Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer BCL9 RNF43 VANGL1 APC LRP5 ZNRF3 LRP6 ARHA RAC1 CTNNB1 PMC10288531__F3A Differential Pathway Expression of Antigen Processing and Presentation IFNG HEL-S-99n TAPBP CANX CUTA B2M TNF PMC7922891__F10 Graphical summary of expression profiling of human lymphoblastoid cells derived from an SS patient BIN2 KLF3 IL15RA SELP PMC5985418__F1 Fibroblast growth factor-23 (FGF23) pathways CYP27B1 NHERF1 TRPV5 WNK4 SGK1 FGFR1 DCT FGFR3 FGF23 PMC7863362__F4 Compared with photoautotrophy, the expression changes of photorespiration biosynthesis pathway in mixotrophy PGP AGXT HPR PMC5053262__F1 UPRmt signal transduction pathway in mammals and worms UBL5 EBP ELF2 CLPP PMC7863362__F5 Expression changes of central carbon and energy metabolic pathways HEL-S-162eP CS GPT PMC8603450__F1 Novel perspective in pancreatic cancer therapy: Targeting ferroptosis pathway TF SLC3A2 KEAP1 GPX4 LPCAT3 FACL4 SLC7A11 STEAP3 BCAT2 PIR HEL110 LCN2 ATG5 PMC1489534__F3 Regulation of cell wall gene expression during the cell cycle (A) and in response to external stimuli (B) GSC2 GAS1 ACE2 SPI1 PMC8603450__F2 Novel perspective in pancreatic cancer therapy: Targeting ferroptosis pathway TF STEAP3 HEL110 LCN2 PMC8223826__F1 Exosomes in diagnosis and treatment of colorectal cancer CD81 CD9 CD63 PMC5912962__F1 Comprehensive Review of Genetic Factors Contributing to Head and Neck Squamous Cell Carcinoma (HNSCC) Development in Low-Risk, Non-Traditional Patients FANCG ATR FANCA PMC3410226__F1 Insulin signaling pathway CRP PHLPP1 TRIB3 ENPP1 PMC4211543__F1 PrPCsignaling via SFKs FYN MBP EGFR BACE1 SRC CTNNB1 PMC7190874__F4 Heart analysis H2AB1 HEL-S-103 CD80 DBP HEL-S-62p MYOT NMB HEL-S-310 NFIL3 DRD2 RPL17 RPL27 HEL-S-72p JUN RPL12 CRY1 CD19 C1orf51 MMP9 TMOD4 FGF2 CDK105 RPL3 ATF3 c-fgr PMC7190874__F7 Kidney analysis LPL FBN1 UBC COL1A2 FASN IGFBP1 SPARC UCP1 FABP4 ITGAX PCK1 COL1A1 PDK4 CIDEA NPY PMC9256076__F1 Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review) UCP2 CD36 CD14 BCAT1 HEL-S-11 MYC KRAS PMC8949121__F6 Integration of Transcriptomic and Proteomic Analyses Reveals New Insights into the Regulation of Immune Pathways in Midgut of Samia ricini upon SariNPV Infection RBX1 SIAH1 APC LRP5 LRP6 SKP1 PMC10288531__F2A Differential Pathway Expression of Cardiac Muscle Contraction Pathway TRDN TEC TH TNC HRC CASQ2 PMC8319020__F1 Sialic acid O-acetylation: From biosynthesis to roles in health and disease CAS1 CMAS SLC35A1 SIAE PMC7824874__F3 The IRF3 signaling pathway by the UPS following LPS exposure TBK1 DTX4 IRF3 CXCL10 CYLD TRIM21 PMC7824874__F2 Key contributions of the UPS to the regulation of the NFKB signaling pathway in response to LPS TLR4 OTULIN TRAF6 TNF MYD88 PMC4757551__F5 Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01 PCK2 C2 ASNS PMC2722510__F7 Proposed pathway involved in the regulation of the osteoblast F-actin cytoskeleton, based upon previous literature and the current experimental results GIP ARHA PTH PMC11646733__F1 Efficacy of Oroxylin A in ameliorating renal fibrosis with emphasis on Sirt1 activation and TGFB/Smad3 pathway modulation HK2 SIRT1 PMC3679459__F1 TRAIL apoptotic pathway BAX BCL2 FADD PMC4905055__F2 Tumor metabolism provides precursors for biomacromolecule synthesis ACLY SDHA EHHADH PDHA1 PGAM2 HEL-S-133P HEL-S-162eP SPHK1 PMC1952634__F4 Evolving biology and treatment of prostate cancer SHBG PTEN GRB2 PMC9541002__F2 LINC00467: an oncogenic long noncoding RNA HTRA3 EZH2 CTNNB1 SIRT6 PMC355851__F8 Proposed model for the observed inhibitory effects of Alpha-catulin and Alpha-catenin on the activation of cyclin D1 transcription RHO CCND1 CTNNB1 PMC8140599__F3 Interaction network of selected proteins with changes in their abundance in the liver of rats exposed to distress and piracetam HTRA2 CDC42 HEL113 UGGT1 PSMA8 CANX SLC25A13 AIM2 FADS2 GANAB MAST2 COX2 MAST3 AP2A2 CPT2 HEL-S-44 PMC9616781__F1 Molecular Effects of Environmental Enrichment on Alzheimer’s Disease BACE1 PLG BDNF PMC9104724__F4 Yeast as a Model to Find New Drugs and Drug Targets for VPS13-Dependent Neurodegenerative Diseases RCN2 PMC8014260__F1 Toll‐like receptors in the pathogenesis of COVID‐19 IRF3 IRF7 TRAF3 TRAF6 IRAK4 PMC4479266__F8 Sry-type HMG box 18 Contributes to the differentiation of Bone Marrow-derived Mesenchymal Stem Cells to Endothelial Cells VWF EGR1 SOX18 MEF2C PMC3618530__F8 Interleukin-1B enhances cell migration through AP-1 and NFKB pathway dependent FGF2 expression in human corneal endothelial cells IL1R1 TRAF6 IL1B PMC8727820__F3 Interaction between gut microbiome and anti-tumor drug therapy RHEB STAT3 BAX LTA IRAK1 BCL2 KRT7 MTOR CCND1 CTNNB1 MYD88 PMC3253558__F1 Conserved Herpesvirus Kinases Target the DNA Damage Response Pathway and TIP60 Histone Acetyltransferase to Promote Virus Replication XPA ZW10 AURKC PJA2 NUP107 RPS6KA2 CRY1 UTP18 SNCA BMX NR1C2 PCNP PPP2CA STK33 PEX2 BFAR ZNF397 c-fgr ZSCAN2 CHGB CSRP3 MLX MNAT1 ZNF35 PMC6215106__F7 Autophagy in response to the Zearalenone–induced G2/M cell cycle arrest MTOR CCNB1 CDC25B PMC2888474__F2 Genetic Alterations in Glioblastoma Occur Frequently in 3 Cellular Signaling Pathways EGFR PTEN CDKN2B RB1 MDM4 CDKN2A CDK6 CDKN2C CCND2 NF1 PDGFRA ERBB2 MDM2 CDK4 PMC3862694__F10 PTEN Increases Autophagy and Inhibits the Ubiquitin-Proteasome Pathway in Glioma Cells Independently of its Lipid Phosphatase Activity RHEB TSC2 TSC1 PTEN IRS1 PMC7015041__F8 Molecular mechanisms involved in PLAG1 regulation in OC cells PLAG1 IGF1R IGF2 IRS1 PMC8883486__F1 Canonical and non-canonical NFKB pathway LTBR RELB IL6 PMC8330570__F7 THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy THADA PMC6581583__F3 Inflammatory response due to the signaling cascade when HMGB-1 interacts with surface receptors TLR2/TLR4, TREM1, and RAGE CDC42 HMGB1 TREM1 IRAK1 IRF3 IRAK2 TRAF6 IRAK4 RAC1 MYD88 TLR4 GRB2 SRC PMC7864012__F2 One-carbon metabolism around the folate cycle, methionine cycle and trans-sulfuration pathway GLDC DHFR CTH HEL-S-61p MTR PMC9143066__F1 Analysis of S-Adenosylmethionine and S-Adenosylhomocysteine: Method Optimisation and Profiling in Healthy Adults upon Short-Term Dietary Intervention PMC5134889__F2 Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases ZAP70 PLCG1 LAT ITK LCK PMC7864012__F1 Serine-glycine biosynthesis pathway PHGDH PSAT1 PSPH PMC2233890__F4 Multiple ERK scaffold regulate growth factor and adhesion signaling CDC42 ARF1 ARF6 ARF3 ARF5 PMC10879038__F4 Programmed endothelial cell death pathways RIPK3 GPX4 RIPK1 MTOR PMC10879038__F3 GSK‐3B as a converging point in key signaling pathways regulating BBB integrity post‐stroke TSC2 TSC1 UNC5B APC LRP5 LRP6 CTNNB1 PMC6660834__F1 Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease SFRP5 APC LRP5 LRP6 ARHA NLK CTNNB1 PMC10528086__F2 When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex APC LRP5 LRP6 MTOR CTNNB1 PMC10528086__F1 When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex APC LRP5 LRP6 CTNNB1 PMC2747034__F1 MTDH/AEG-1 promotes tumor progression through the integration of multiple signaling pathways HMOX1 MTDH ALDH3A1 GSK3B BNIP3 DPYD AKR1C2 MYC LEF1 ABCC11 CTNNB1 PMC7719303__F2 Inflammation and ROS CXCL12 NOXA1 TRADD NLRP3 TXNIP IL16 RIPK1 ROMO1 TRAF2 DIABLO IL1B FADD PMC2657775__F7 Enrichment of TGF-beta signaling pathway IFNG SMAD2 SMAD4 NODAL ARHA PMC2657775__F6 Enrichment of Wnt signaling pathway ROCK2 APC CER1 SMAD4 ARHA NLK PROC PMC308834__F1 A representative example of a plant pathway in MetaCyc MAL GIP PMC7073720__F4 Prostaglandin biosynthetic pathway COX1 PTGIS COX2 C2 PTGES PMC2657775__F9 Enrichment of Jak-STAT signaling pathway EPO IL6 PIN1 PMC11161882__F3 Differentially regulated pathways obtained from IPA analysis A RPL3 SORD EIF1AX SOX18 NBL1 SYBU PMC2790404__F2 Viral infection elicits a variety of antiviral cellular responses IFNE TLR3 IRF3 PMC6142689__F5 Pathway of NRF2-mediated oxidative stress response GSTT1 CP PMC6616367__F1 Tumor necrosis factor (TNF) receptor, IkappaB kinase/nuclear factor kappa B (IKK/NFKB), c-Jun N-terminal kinase (JNK), and apoptosis in hepatocellular carcinoma (HCC) development RIPK3 TG TRADD TAB3 RIPK1 TNF TRAF2 FADD PMC6142689__F3 Pathway of calcium signaling predicted by IPA TPM3 NFATC1 HDAC11 CP PMC3572677__F1 Scheme of apoptosis pathways FADD PMC8363758__F6 Schematic illustrating RhoA-actin-serum response factor (SRF) signalling pathway PER2 PER1 NR1D1 ARHA PMC8496250__F1 Biological Significance of Long noncoding RNAs Dysregulation and their Mechanism of Regulating Signaling Pathways in Cervical Cancer FRAT1 FRAT2 APC MTOR CCND1 CTNNB1 PMC3110643__F7 Cartoon representing CsA-mediated activation of TGF B1-dependent signaling leading to epithelial-mesenchymal transition in epidermoid carcinoma cells CDH2 SP1 SMAD2 SMAD4 PMC3101847__F1 Pathways that regulate aging RHEB TSC2 TSC1 PMC2552992__F9 Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease EGR1 ATG3 E2F4 HDAC2 PMC6348202__F2 Proteomic and Functional Analysis Reveals an Increased Chk1 Activity in Lung Cells that Contributes to Cisplatin Resistance(A) Identification of genes involved in differential cisplatin response EGF ATR CBL IF2B1 ATM TPO PTEN RHO PMC7081792__F1 Hippo and hyperplasia – TEAD promotes mTORC1 activation post-injury LATS1 RHEB LATS2 PTEN PMC8745114__F1 B Lineage Cells in ANCA-Associated Vasculitis BCR GC PC PMC3777492__F1 IGFBP5 enters cells through its own surface receptor or by freely diffusing into the cytoplasm RAF1 IGF1 IGFBP5 SHH RHO PMC2879563__F1 Subdivision of the estrogen metabolic pathway NAT2 HEL-S-22 UGT2B11 PMC5040721__F4 Possible antagonistic effects of obesity on myocyte signaling to accelerate muscle atrophy KLF15 GC BNIP3 PTEN SOCS3 IL6 MTOR IL6R PMC5040721__F3 Possible adverse effects of obesity on osteoclast TRADD CCR2 TRAF5 IL6 GRB2 MTOR SRC TRAF6 TRAF2 IL6R PMC5040721__F2 Possible adverse effects of obesity on osteoblasts STAT3 FSTL1 GSK3B MTOR IL6 RHO RUNX2 SHE IL6R SOST FOXO1 MGP GC ATF4 PTH GRB2 PMC9162455__F2 Down-regulation of MHC-II antigen presentation pathway by tumour cells and possible therapeutic targets IFNG STAT1 HLA-DRA CD74 MHC2TA EGFR IRF2 CREBBP EZH2 MYC PMC5133177__F1 Mitochondrial Fe–S cluster biogenesis and Isu degradation PIM1 FES PMC9162455__F1 Down-regulation of MHC-I antigen processing pathway by tumour cells and possible therapeutic targets IFNG STAT1 DUX4 EGFR IRF1 GIP EZH2 TAP1 B2M SPPL3 MYC SND1 PMC7996041__F5 Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery IRAK1 TRAF6 IRAK4 MYD88 PMC9441765__F3 Emerging roles of ferroptosis in glioma SOCS1 SLC3A2 GPX4 LPCAT3 FACL4 SLC7A11 PMC8042664__F5 Schematic model IL18 IL1B PMC2913704__F6 TGFB1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation TGFB1 SMAD2 SMAD4 NOTCH1 PMC9441765__F5 Emerging roles of ferroptosis in glioma TFR2 GPX4 SLC7A11 ATF4 PMC7764345__F1 Insulin signaling pathway; Insulin stimulates the insulin receptor (IR), leading to phosphorylation of insulin receptor substrate (IRS) IRS1 PMC4789572__F7 Circadian-disruption-induced gene expression changes in rodent mammary tissues ATR FAS PERP PTEN MYC FOS TSC2 BCR CDR2 CASP3 CDK2 ATM MDM2 PMC7803292__F15 Involvement of the Akt and Kras pathway in breast cancer KLF3 TPD52 KLF8 MDM2 MTOR KRAS CDK4 PMC9600751__F4 Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions PARP4 KLLN PTEN MTOR PMC9600751__F3 Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions BRAF TPO PTEN MTOR NOX4 RET PMC8797975__F5 Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease MLST8 TSC2 RICTOR TSC1 APC AKT3 PTEN ARHA MTOR DEPTOR RAC1 EIF4E PMC5505746__F1 Proposed potential mechanism of MDSC-mediated T cell suppression through LILRB1/2 and HLA-G interactions STAT3 HLA-G LILRB2 ARG1 LILRB1 PMC7203913__F9 Arabidopsis Plastidial Glucose-6-Phosphate Transporter GPT1 is Dually Targeted to Peroxisomes via the Endoplasmic Reticulum RPE PXN NADK HEL-S-64p PMC5035901__F4 KEGG pathway analysis of the validated miRNAs MAPK1 CASP9 TGFA SOS1 CREB5 PDGFA GSK3B PTEN IGF1R CTNNB1 RB1 CDKN1A NFKB1 PI3 BCL2 MDM2 GRB2 LEF1 CCND1 PMC6358521__F1 Lessons learned from the study of human inborn errors of innate immunity CD40 STAT3 IL17RC IFNGR1 LTBR TIRAP RELB DCT TLR5 IRAK4 MYD88 SHARPIN STAT1 IFNGR2 TLR1 BCR RELA ISG15 JAK1 IL23R TYK2 IL12RB1 PMC7062075__F4 KEGG metabolic pathway map showing significantly differentially expressed genes within the cell cycle pathway for midgut control versus UCS CDK7 E2F4 SMAD4 CDK2 SKP2 PMC3769161__F7 Interleukin-17 Enhancement of the Interleukin-6 Signaling Cascade in Astrocytes IL17RC SOCS3 IL1B PMC6358521__F2 Lessons learned from the study of human inborn errors of innate immunity TBK1 MAVS STAT2 IRF9 TLR9 IRAK1 IRF3 IRF7 TRAF3 IRF8 TRAF6 IRAK4 MYD88 STAT1 TLR3 USP18 RELA IFNAR1 TLR8 TLR7 ISG15 TYK2 PMC7062075__F5 KEGG metabolic pathway map showing significantly differentially expressed genes within the cytokine–cytokine receptor interaction pathway for hindgut control versus UCS MPL SAG PRL LEPR TPO EDAR TNLG7C PMC7881328__F2 Anti–Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients CD80 MMP25 TANK PML MARCKS HIF1A CS TRAF3 CCL2 HM13 MAPK3 CCL23 IFNG MAP3K8 RIPK2 CDA AHR P2RX4 HEL-S-89n HAMP CXCL2 IL6 TNF CXCL10 VHL CD44 CEBPA NFKB1 EDN1 NFKBIA BCL2 CCL4 TRAF1 HILPDA GRB2 CCL20 PMC8516342__F8 Downregulation of microRNA‐6125 promotes colorectal cancer growth through YTHDF2‐dependent recognition of N6‐methyladenosine‐modified GSK3B GSKIP GSK3B YTHDF2 CYC1 HEL-S-11 PMC3193242__F7 The cross-talk between IKK family members in the MyD88 signaling pathway TBK1 TAB3 TANK TRAF6 PMC3137012__F8 Hypothesis of insulin signaling pathways associated with the regulation of CIDEA and CIDEC expression in human adipocytes CIDEA CIDEC PMC6271692__F5 Interactomic analysis by Ingenuity Pathway Analysis (IPA) of significant molecules ZFP36 NOS2 IL12A CCL3 NAMPT IL17A VEGFA IL1A IL6 TNF EFNA1 CCL2 STAT1 RORC RELA CCR7 IL2 RPRM CCL4 NRF MGMT PMC7516013__F2 Farnesoid X receptor (FXR) regulates bile acid (BA) synthesis in a tissue-specific manner FGF8A CYP8B1 CYP7A1 FGFR4 PMC8269153__F3 NRF2-Related Epigenetic Modifications in Cardiac and Vascular Complications of Diabetes Mellitus KEAP1 AHR PMC8269153__F2 NRF2-Related Epigenetic Modifications in Cardiac and Vascular Complications of Diabetes Mellitus FAS KEAP1 SIRT1 PMC8414903__F2 Ferroptosis Pathway by Ubiquitination SLC11A2 SLC3A2 TFRC FTL STEAP3 FES SLC7A11 HEL-S-64p PMC4808028__F9 Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism LTBP1 PMC11127239__F2 Cytotoxic effects of deoxynivalenol (DON) and mechanisms of diarrhea induction FTL NLRP3 CFTR PMC3131835__F3 Sphingosine 1-phosphate (S1P) generation and ALI-associated single-nucleotide polymorphism (SNPs) in the S1P biosynthetic pathway CD44 S1PR1 S1PR3 TNF PMC11965322__F1 STRING PPI analyses CXCL12 TGFB1 GPX4 EPO HIF1A IGF1R RIDA SMPD1 ANTXR1 HMOX1 GP1BA VEGFB ADAM17 FLT4 DCLK1 SP4 TLR4 DPP4 FLT1 KDR SELENOP IL1B TIMP3 IL10 CFH LRP5 AGTR1 IHH TBX5 TNF ANGPT2 FZD4 SELS TSPAN12 ADRB2 PRP4K ARHGEF7 BDNF NDP PMC3269658__F5 Differentiation pathways of CSCs CNTF GFAP BMPR1A JUNB BMP4 SOX2 BMP2 SOCS3 MTOR ID1 HES1 ID3 PMC7448569__F4 Gene expression profiles of the NF-kB signaling pathway in breast cancer CD40 SYK LTA TRADD TIRAP LAT RELB ELL CD14 BLNK TRAF3 TRAF6 DAO PARP1 LTB CNTF NGF BTK BCR COX2 ATM TRAF2 LBP PMC9520296__F2 Pyroptosis as a candidate therapeutic target for Alzheimer’s disease GSDMD NLRP3 ABO GSK3B MAF TIGAR IL1B PMC8506221__F5 Schematic molecular pathway of LE regarding ICAM-1 dan E-Cadherin expression TLR4 AHR PMC7167284__F3 Chronic HCV replication in liver cells induces a multifaceted stress response CD81 NPC1L1 EGFR LDLR CLDN1 PMC8465124__F1 Splice and Dice: Intronic microRNAs, Splicing and Cancer DGCR8 DBR1 DROSHA PMC3482543__F7 Toll-Like Receptor 2-Mediated Intestinal Injury and Enteric Tumor Necrosis Factor Receptor I Contribute to Liver Fibrosis in Mice TLR4 ARHA TNF PMC5206567__F7 The locus coeruleus (LC) pathway to cortex and its involvement in stress GALR1 GALR3 PMC6167442__F2 Detailed diagram for fatty acid and phospholipid synthesis in C PSD C1S PMC2329845__F2 IPA of the genes encompassed by the conserved 166 signatures and belonging to the Wnt signal transduction pathway CD44 HDAC1 JUN SOX9 TCF4 PIN1 AXIN2 PARP1 WIF1 CTNNB1 PMC6782198__F7 Postreceptor adaptations of the cAMP pathway observed in response to chronic antidepressant treatment BDNF PDE4B PDE4A PMC3826451__F4 Intracellular PRR signaling pathways involved in RSV and hMPV-induced gene expression MAVS NLRP3 IL16 NOD2 IRF3 PMC6613384__F3 Protective effects of fibroblast growth factor 21 in cardiovascular disease FGF21 ABCA1 ACE2 PMC8895452__F8 RASSF1A independence and early galectin‐1 upregulation in PIK3CA‐induced hepatocarcinogenesis: new therapeutic venues STAT3 COX2 FASN PMC3826451__F2 Toll-Like Receptors (TLR) signaling pathway involved in RSV and hMPV-induced gene expression TLR3 TLR4 TLR8 IRF3 TLR7 MYD88 PMC7448569__F6 Gene expression profiles of the IL-17 signaling pathway in the breast cancer group TH ELL IL2 REL FADD PMC7448569__F5 Gene expression profiles of the C-type lectin receptor signaling pathway in the breast cancer group IL-21 STAT2 FRK RELB IL2 IL11 IL6 NPAT CYLD SET PMC9326442__F4 Hypercatabolism and Anti-catabolic Therapies in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome STAT3 IGF1 IGF1R MTOR PMC9308248__F3 Promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors RHEB MLST8 TSC2 TSC1 DEPTOR PMC9609612__F12 Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2 LATS1 LATS2 YAP1 PMC4708174__F1 PI3K–AKT–mTOR pathway and drug targets RPS6 TSC2 TGFA TSC1 PTEN GRB2 IRS1 PMC3399428__F2 “Hpo signaling pathway in Mammals and the cross-talk with RASFF1A signaling.” Schematic representation of mammalian Hippo kinases cascade and interconnections between Hippo pathway and rassf1a protein signal LATS1 FRMD6 LATS2 FAS RAF1 NF2 TEF PMC8039545__F7 Visualization of the differential gene regulation in PBMCs responding to A ERG REL SET PMC3707895__F6 NGF-Induced Cell Differentiation and Gene Activation Is Mediated by Integrative Nuclear FGFR1 Signaling (INFS) TH NGF DCX FGFR1 FGF2 PMC4394589__F6 Regulation of genes in IL1/TLR signaling pathways TBK1 TIRAP IL33 CD14 IRAK1 IRF3 SOCS3 TRAF3 TRAF6 IRAK4 MYD88 IL16 CYLD PMC2645538__F5 Possible neuroprotective mechanisms of mild mitochondrial uncoupling and caloric restriction in neurodegenerative diseases BDNF SIRT1 PARP1 PMC4394589__F5 Regulation of genes in the JAK/STAT signaling pathway SOCS1 IFNA7 STAT3 IFNA6 IFNA8 IFNA13 IFNA14 IFNA10 JAK3 IF1AA9 SOCS2 SOCS3 STAT1 IFNGR2 SOCS5 IFNGR1 STAT2 SOCS4 PTPN1 IFNA4 IFNA2 IL6 PTPN6 SOCS7 IFNAR2 IFNAR1 PIAS1 STAT4 IL6ST JAK1 TYK2 PMC1876750__F2 Focal Adhesions Regulate AB Signaling & Cell Death in Alzheimer’s Disease KEAP1 BPTF PMC3523565__F1 Simplified scheme of the mitogen-activated protein kinase (MAPK) (RAS-RAF-MEK-ERK) signaling pathway.Notes:BRAF and NRAS are the most commonly mutated oncogenes in melanoma ARAF BRAF NRAS PTEN IGF1R MTOR PMC4222988__F3 A) Compensatory over-activation of signal transduction pathways induced by dual PI3K/mTOR inhibitors RHEB EGF TSC2 GRB10 TSC1 INSR PAK1 PTEN GRB2 INS IRS1 PMC4222988__F2 A) Compensatory over-activation of signal transduction pathways induced by rapamycin-mediated suppression of negative feedback loops RHEB EGF TSC2 GRB10 TSC1 INSR PAK1 PTEN GRB2 INS IRS1 PMC7756074__F7 Proposed model of the non-genomic actions of 1,25 dihydroxyvitamin D3 (1,25 D) in the lungs infected with SARS-CoV-2 NR1i1 STAT1 STAT2 IRF9 NFKB1 JAK1 TNF PMC4222988__F1 Signaling through PI3K/mTOR and Ras/Raf/MEK/ERK pathways is controlled by negative feedback loops RHEB EGF TSC2 GRB10 TSC1 INSR PAK1 EGFR PTEN GRB2 INS IRS1 PMC7797090__F5 Metabolic pathway of glycerol and glucose bioconversion to butanol in Clostridium sp HEL-S-162eP HBD PMC8753885__F3 Identification of cardiomyopathy-related core genes through human metabolic networks and expression data IDE TH NME3 GMPR2 COMP NME7 RRM1 RRM2 GLA NME6 PNP NME2 OMP GUK1 ADSS APP RRM2B PKLR GMPR AK5 NUDT2 PMC4001054__F1 Proposed schematic models for the role of different lncRNAs (green) in neural development DLX1 DLX6 NEUROG1 SHH DLX2 DLX5 PMC5866379__F14 Cartoon showing hypothetical activation of CFTR by cigarette smoke extract via prostanoid and store-operated cAMP signaling pathways COX1 COX2 STIM1 CFTR PMC4980531__F2 Multifaceted regulation of T cell responses by ROS STAT3 FAS STAT4 PMC3942790__F3 Hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches BMP6 HFE HFE2 PMC3942790__F2 Hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches BMP6 HFE TMPRSS6 HFE2 PMC6892740__F4 Major phospholipid biosynthetic pathways, genes involved, and subcellular localization of the encoded enzymes.PTDSS1,PCYT1A, andPISD from this study (all in red font) are associated with syndromic skeletal dysplasias PTDSS2 PCYT1B CHPT1 PTDSS1 PEMT PC CEPT1 PCYT2 CHKA PISD CHKB PMC4263682__F1 An example of a cluster illustrating Ras activation CDC42 EGF EGFR APC COIL IQGAP1 GRB2 RAC1 CTNNB1 S100B PMC10530945__F1 Remodeling of Tumor Microenvironment by Nanozyme Combined cGAS–STING Signaling Pathway Agonist for Enhancing Cancer Immunotherapy CGAS IRF3 TNF PMC7307178__F8 Current model for the suppressive effect of MERS-CoV N protein on the RIG-I-induced type I/III IFN expression TRIM25 IRF1 IRF3 PMC2678599__F7 Filia's role in ensuring euploidy of early cleavage embryos AURKA ARHA PLK1 PMC8194085__F1 Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine CAD CDA HEL-S-62p C2 UMPS DHODH PMC9253381__F5 Elabela Attenuates the TGFB1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis SMAD2 SMAD4 PMC3911241__F4 Examples of network refinements and reannotations KYNU KMO HAAO PMC3246786__F2 The role of CYLD in canonical and noncanonical NFKB pathway CD40 RELB TRAF3 CYLD TRAF2 PMC9265592__F1 Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives STAT3 S1PR1 S1PR3 S1PR2 MTOR S1PR5 S1PR4 PMC5852471__F8 Cell cycle arrest and apoptosis induced by BOS-102 in A549 cells BAX CCND1 CDK4 PMC8851844__F8 Cluster analysis of splenocyte microRNAs in the pig reveals key signal regulators of immunomodulation in the host during acute and chronic Toxoplasma gondii infection tal-1 RAD1 STAT2 IRF9 RELB NPAT CYLD PMC8345935__F1 New Insights into Cancer Targeted Therapy: Nodal and Cripto-1 as Attractive Candidates SMAD2 APC GSK3B LRP5 SMAD4 LRP6 NODAL SRC CTNNB1 PMC4820109__F3 Association of MicroRNA-196a2 Variant with Response to Short-Acting B2-Agonist in COPD: An Egyptian Pilot Study TGFBR2 ACVR2B COL1A2 SMAD2 PDGFRA ROCK1 DIAPH2 NODAL GRB2 OCRL ITGAV PMC7485269__F4 Role of mTOR-dependent processes in NMJ alteration upon aging IGF1 MTOR PMC5080721__F4 mRNA microarray analysis (microarray cohort; n = 36 GBMs) revealed SVZ-dependent differential gene expression of key hierarchies of the Notch pathway HES4 MAML3 JAG2 NOTCH3 DLL3 PMC7485269__F2 (m)TOR pathways and downstream factors and processes in fly and mammals EIF4B ULK1 ELF2 PTEN EIF5 IRS1 EIF4E RHEB TSC2 ELF1 SUI1 TFEB TBC1D7 ELF5 ELF3 PMC7485269__F1 General organization and function of mammalian neuromuscular junction (NMJ) ACHE MUSK LRP4 PMC4085325__F4 SphK1/S1P/S1PR1 feed-forward loop sustain signals promoting colon tumorigenesis.Notes: SphK1 produces S1P, which is kept in the cell and/or is exported in the extracellular milieu STAT3 S1PR1 SPNS2 SPHK1 PMC11766336__F2 lncRNAs regulate the progression of malignant brain tumors MYC PMC8335817__F1 Interleukin‐25: New perspective and state‐of‐the‐art in cancer prognosis and treatment approaches STAT3 IL25 TRADD EGFR IL17RB TRAF6 FADD PMC4028717__F7 Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the Death Receptor pathway BAX FADD PMC10487929__F10 Network connectivity pathway map of ACE2’s downstream effects of simulated SARS-CoV-2 infection on predicted activity of the NISP IFNG SNCA IL6 CCL5 PTGS2 CCL2 TNF ACE2 IL1B PMC8766672__F2 Adaptive Mechanisms Make Lupin a Choice Crop for Acidic Soils Affected by Aluminum Toxicity ART1 CS PMC10487929__F11 Downstream effect analysis of molecules downstream ACE2 and upstream of the NISP in the network connectivity pathway map of ACE2’s downstream effects of simulated SARS-CoV-2 infection on predicted activity of SNCA and PD IL6 CCL5 PTGS2 CCL2 TNF IL1B PMC8194085__F3 Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine STAT3 EGF CAD EGFR BRAF PTEN UMPS KRAS DHODH PMC8894518__F1 Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy AXL EGFR PTEN MTOR PMC8023785__F1 Emerging concepts in the science of vaccine adjuvants IL10 CGAS RAF1 TIRAP IL33 TLR9 TLR5 IRF3 IRF7 TNF MYD88 TLR1 NLRP3 TLR3 TLR4 TLR8 TLR7 PMC9032397__F1 Vitamin D and Ocular Diseases: A Systematic Review CYP2R1 CYP27B1 DBP CYP24A1 CYP27A1 PMC8894518__F3 Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy TGFBI SMAD2 DLL4 APC GSK3B JAG2 SMAD4 NOTCH2 NOTCH3 DLL3 NOTCH1 CTNNB1 PMC4458271__F2 Role of ceramides in neuronal apoptosis BAX BAD UROS PMC2682514__F1 Nodes with the highest relative betweenness centrality (in orange) and their interacting partners (blue) in the pancreatic cancer pathway EGFR GRB2 PMC9191826__F9 Combined treatment with anti‐PSMA CAR NK‐92 cell and anti‐PD‐L1 monoclonal antibody enhances the antitumour efficacy against castration‐resistant prostate cancer MICA MTOR JAK1 MICB PMC7488177__F2 Potential role of LRG1 in abnormal angiogenesis of diabetic nephropathy associated with TGFB1 signaling pathway HMFT1766 SMAD1 DKFZp781O1323 SMAD2 PMC3688662__F1A MODELS OF INSULIN RESISTANCE AND HEART FAILURE FOXO1 MTOR IRS1 PMC3219052__F1 SRC-3Δ4 isoform acts a signaling adaptor for EGF-dependent cancer cell migration and invasion EGF NCK1 EGFR GRB2 PMC8984119__F1 Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions ACLY ACSS2 PDC PMC8573113__F2 TDP-43 and ER Stress in Neurodegeneration: Friends or Foes? ATF4 EIF2A XBP1 PMC10562563__F1 Toll-Like Receptors (TLRs) signaling pathways, intra-, and inter-signaling crosstalk circuits, and their regulatory loops TBK1 TIRAP TAB3 TLR9 IRAK1 TLR5 IRF3 TRAF3 TRAF6 IRAK4 MYD88 IFNG TLR1 TLR3 TLR4 TLR8 TLR7 PMC2669548__F1 Generalized schematic presentation of signaling pathways targeted by molecular therapies in malignant glioma EGFR PTEN MTOR PMC5525062__F2 Pathological pain and the neuroimmune interface CXCR3 HMGB1 CCR2 MMP9 TNF CCL2 CR1 MYD88 ADRBK1 IL1R1 NRG1 NLRP3 CCL21 TLR4 CCR7 MMP2 LYN BDNF IL1B PMC10136831__F3 Crosstalk between PGE2 and EGFR TF EGF EGFR CXCL1 IL8RB SRC PMC5722817__F9 Two HEB-dependent pathways of GDT17 cell development IFNG CD24 SOX4 ID3 PMC10136831__F1 Biosynthesis of prostaglandins COX1 COX2 PMC5380184__F2 Related cell process and diseases with potential disease biomarkers induced by particulate matter visualized by Pathway Studio TGFB1 CSF2 FIS1 ID2 GCLM PDGFA SMAD6 STC2 TNF CYP1A1 CXCL8 ID1 OGG1 IFNG BMP4 SRXN1 MX1 PMC3528566__F2 Carbohydrate metabolism and ATP synthesis HEL-S-162eP CS MTOR PMC2773416__F6 Diagrammatic representation of intracellular pathways that lead to the production of IL-12p40 and the mechanisms of azithromycin (AZM) to inhibit the expression of IL-12p40 upon the stimulation of LPS/IFNG STAT1 JUNB TRAF6 MYD88 PMC5858703__F1 Retinoic acid-related Orphan Receptor G (RORG): connecting sterol metabolism to regulation of the immune system and autoimmune disease CYP51A1 EBP SQLE SC5D DHCR24 FAXDC2 HMGCS1 ACAT1 HMGCR DHCR7 FDFT1 HSD17B7 TM7SF2 PMC420359__F8 RA regulation of reciprocal interactions between the visceral endoderm and mesoderm that control endothelial cell growth and vascular remodeling DKFZp781O1323 IHH VEGFA PMC2440498__F1 Signaling cascades initiated via TLR2- and TLR4-dependent activation TBK1 TLR1 TIRAP TLR4 IRF3 TRAF6 MYD88 PMC3520610__F5 Targeting the TGFB signalling pathway in disease TF SMAD2 SMAD4 PMC7672213__F6 Potential apoptotic pathway for anticancer effects of RPL against lung cancer ATM ChAT DIABLO PMC5423198__F5 Visual representation of the network generated by Ingenuity Pathway Analysis (IPA) PPARG HEL-S-76p HIF1A TYMS MYC HUWE1 RB1 EZR CTDSPL SHMT1 KL SULF1 CRLF2 CD6 MFAP1 NTRK2 HTATIP2 HSF4 GNRHR DDX11 EDNRB RUVBL2 ENO1 PRODH NR3B3 LMNA PMC2877979__F8 Schematic representation of some pathways and networks modified during strain improvement program according to results obtained after proteome comparison of NRRL 1951, Wis 54-1255, and AS-P-78 strains CS PMC3520610__F2 Targeting the TGFB signalling pathway in disease TRAF4 JUN SMAD4 RHO TRAF6 DROSHA PMC1479345__F7 Pathway analysis LAMP2 DBI POLR2A MYC TCEA2 PMC3520610__F1 Targeting the TGFB signalling pathway in disease SMAD2 SMAD4 DROSHA SKI PMC9402773__F2 Wnt Signaling Pathways: A Role in Pain Processing APC GSK3B CTNNB1 PMC1479345__F6 Pathway analysis BARX1 HRAS STAT3 APOC1 THRSP CD36 BMP4 FGFR3 FOXA3 APP FOXA2 ALAS2 PMC1479345__F5 How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome SF3A2 SF3A1 DCT DVL2 PLK1 PMC1479345__F4 Pathway analysis ABCE1 JUN HGF LEP GNAT1 DUSP9 SNCA PCK1 BTK FABP5 HOXA13 IGHMBP2 IKBKB BMP2 TPSAB1 PMC1479345__F3 Pathway analysis JUN JUND TGFB1 CD82 FASN RGS16 CRYAA YY1 ARHA TNF SLC27A1 CDKN2A HEL-S-102 IL2 PSMB10 HOMER2 PMC12192670__F2 Mechanistic network of the pleiotropic regulatory effects of the vitamin D/VDR signaling pathway in the pathophysiological microenvironment of DFUs (by Figdraw) NR1i1 NGF TRPV1 BDNF PMC12192670__F1 Vitamin D metabolic activation and signaling pathways (by Figdraw) DBP DHCR7 CYP27A1 PMC4213374__F1 This figure illustrates some of the mechanisms by which CD40L can influence on different cell functions and the processes by which these altered cells can impact on host immunity in neoplastic diseases TF CD80 IL2 PMC9098154__F6 Schematic explaining the role of LINC00926 in orchestrating the regulation of WNT10B in order to regulate IFNG expression WNT10B IFNG PMC5096382__F4 DEVELOPMENTAL CIGARETTE SMOKE EXPOSURE II: HEPATIC PROTEOME PROFILES IN 6 MONTH OLD ADULT OFFSPRING ALB HEL-S-134P GLUD1 ALDH2 GSTM5 HEL-S-61p PMC4833894__F1 Different molecules involved in the mTOR activation cascade MTOR IRS1 EIF4E PMC9520276__AF1 XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression CGAS TGFB1 NLRP3 IRF3 PMC9487300__F7 Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis TF HGF IL13 IL4 TNF PMC2850399__F7 Mevalonate pathway and the pleiotropic effects of statins CDC42 RHO PMC4879129__F8 ASS234 targets involved in AD pathogenesis BAX BAD APP PMC3159104__F4 Extrinsic signal pathways for regulating pluripotency during reprogramming BMPR2 STAT3 SMAD1 DKFZp781O1323 SMAD2 BMP4 LIF SMAD4 CTNNB1 PMC2832126__F1 The multi-stage autophagic process RHEB ATG10 ATG3 ATG12 UVRAG AMBRA1 BCL2 PTEN ATG5 PMC7695496__F2 Regulation of CH25H expression KLF4 ATF3 TLR4 CH25H IRF3 PMC7189756__F8 Downstream signaling events associated with type I interferon actions in nociceptors STAT3 STAT1 JAK1 EIF4E PMC3784243__F1 Role of the PD-1 Pathway in the Immune Response APC IL2 PTEN PMC2785769__F7 Proposed pathways for promotion (A) and progression genes (B) influenced by TLR4 TNC RAN EGFR S100A8 CCR2 ARG1 CXCL2 AREG CCL5 MYC SPP1 HBEGF EREG HMGA1 PTHLH CHST1 TLR4 GJA1 PMC4175424__F2 Reactive Oxygen Species Adversely Impacts Bone Marrow Microenvironment in Diabetes ATM PTEN HEL-S-64p PMC9380933__F1 mRNA expression of NLRP3 and associated signalling molecules are differently regulated after SE elicited by pilocarpine or kainic acid HMGB1 NLRP3 TLR4 IL18 IL1B PMC8999182__F4 Physiological Electric Field: A Potential Construction Regulator of Human Brain Organoids CDC42 TIAM1 EGFR RHO RAC1 CTNNB1 PMC6631235__F5 SAM on signal transduction pathways FOXM1 APEX1 SKP2 PMC8556195__F1 Plasticity of pancreatic cancer stem cells: implications in therapeutic resistance CD44 SUFU APC SOX2 GSK3B LRP5 JAG2 LRP6 SMO MYC CTNNB1 PMC8713033__F6 Function of CARMIL1 in IL-1 Signaling CARMIL1 IRAK1 IRAK2 SRC MYD88 PMC9191896__F9 Pathway for sex hormone synthesis in the juvenile zebrafish HSD17B3 CYP17A1 HSD3B1 HSD11B2 HSD17B1 PMC6023969__F6 IL-37-mediated intracellular signaling cascades in eosinophils for the suppression of allergic airway inflammation NLRC4 PYCARD NLRP3 TLR3 TLR4 AIM2 S100A9 PMC9406959__F4 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma JAG2 PMC9406959__F7 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma LATS1 WNT5B LATS2 PMC3048376__F2 Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli TGFA EGFR TRAF2 UNK PMC6370039__F1 Relationship between NFKB and autophagy YY1 ATG5 PMC9406959__F2 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma KIF7 SUFU SMO GLI3 PMC6370039__F5 Relationship between the overexpression of YY1 and autophagy FAS PTEN YY1 ATG5 PMC3048376__F5 Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli STAT3 IL10 TGFA IGF1 IL6 MTOR PMC8926145__F4 Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function SUFU BMP2 SMO RUNX2 OTUB2 PMC5986142__F5 Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells ATR SP1 PERP MAL GSK3B SMAD4 SP2 AIDA MYT1 RAD21 CDK7 PI3 CDK2 ATM MDM2 PMC9406959__F8 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma ALDH1A3 HEL-S-53e CRABP2 RBP4 ALDH1A2 PMC6452163__F3 Classical neurotransmitters of clozapine neighborhood in A auto-layout format and B a gamut of multifunctional molecules identified by IPA core and functional analyses (see table 2) HTR1F NTS HRH3 TRH LEP ASIP GRINA OXTR CRH UCN AgRP VEGFA PMC8926145__F3 Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function TRAF6 OTUB2 PMC3048376__F9 Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli IFNG STAT3 IL10 TGFA IGF1 IL4 IL6 MTOR TRAF6 IL1B PMC7905081__F1 Core components of the Hippo signaling pathway and their regulation in the GV and MI-stage oocyte LATS1 LATS2 AMOT NF2 PMC3471227__F1 Hh pathway activation, inhibition, and mechanisms of drug resistance SUFU PTCH1 SMO MTOR CCND1 PMC3865928__F1 Citrobacter Infection and Wnt signaling APC GSK3B CTNNB1 PMC5783456__F2 Ingenuity pathway analysis network identified with differential expressed genes FOXA1 RBP5 DPPA3 Pax9 NEUROD1 AMBP FOXA3 NR0B2 AKR1B10 DEPTOR TLE2 AGR2 RORC EMX2 CCDC110 NR2A2 ABCA8 FOXA2 ABCC5 POU3F2 CLCN4 CHKA AKR1C4 PMC7377830__F2 Tomatidine-target genes associated with the top two KEGG pathways RAF1 RPS6KA1 BRAF MAP2K1 MAP2K2 FOS PMC4170887__F2 Gene interaction networks specific to the varying doses of 60Co radiation exposure ETV6 PCNA NFKB2 CRKL AHR TNFSF10 MBD2 FADD PMC10605613__F3 Cellular regulatory pathways involving PrPC protein in cancer FYN MMP9 SATB1 FLNA MMP11 PMC11049334__F2 Polyphenol-target network and associated signaling pathway and biological function MAPK1 NOS2 NFKB1 NFKBIA PTGS2 MMP9 TNF PMC5654500__F3 Lost in translocation: The function of the 18 kD translocator protein PBR ALAS1 GOPC PCK1 PMC5735915__F8 The c-Myc/miR-200b-3p/PRDX2 regulatory loop HEL-S-2a GSK3B CTNNB1 PMC9519528__F1 Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency CERK tmp_locus_29 CER1 KDSR LPP PMC4782360__F3 Pathway analysis illustrating the link between PM2.5-associated miRNAs in extracellular vesicles and biological pathways related to cardiovascular disease CD40 CXCL12 CSF1 CCR3 IL36A IL6 IL36B CXCL8 IL36RN MMP3 IL36G VCAM1 CXCR4 IL1F10 PMC12181760__F3 Pathways linking gut‐derived metabolite TMAO to CVDs via endothelial, cardiac fibroblast and cardiomyocytes dysfunction SIRT3 NLRP3 SMAD2 SMAD4 VCAM1 SIRT1 IL1B PMC9247141__F3 Organelle-Specific Regulations and Epigenetic Regulators in Ferroptosis FDX2 SLC3A2 SLC25A28 GPX4 DPP4 NFE2L2 FDX1 SLC7A11 GLS2 PMC9247141__F1 Organelle-Specific Regulations and Epigenetic Regulators in Ferroptosis TF SLC3A2 FTH1 LOX FTL STEAP3 GPX4 LPCAT3 FACL4 SLC7A11 PMC3079783__F1 Leptin Signaling in Intestinal Epithelium Mediates Resistance to Enteric Infection by Entamoeba histolytica BAX BAD SOCS3 PMC7952990__F1 Oxidative stress leads to impaired GR function through proinflammatory signaling STAT3 TSLP IL16 IL33 AHR PMC3271643__F3 Putative mechanism of estrogen action in rat Sertoli cells EGFR SRC CCND1 PMC6798321__F2 Schematic presentation of Nipah virus (NiV)-induced modulation of type I interferon (IFN-I) production and signaling TBK1 STAT1 RIGI MAVS TRIM25 TLR3 TLR8 TRIM6 IRF3 IRF7 TLR7 PMC11806010__F4 Clec9a-initiated ITAM-Syk signaling cascade and downstream pathways SYK CLEC9A NLRP3 BCL10 RELB CARD9 PMC8506081__F2 Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer MAGI1 SCRIB SRC CTNNB1 PMC7072699__F1 Metabolic pathway of sialic acids in mammalian cells NEU2 NANP NEU4 GNE NEU3 NEU1 CMAS NANS SLC35A1 PMC7905011__F7 Changing cell’s redox balance (NAD +/NADH) resulting from lactate conversion to pyruvate augments reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and mature skeletal muscle ATG10 ATG3 ATG12 MTOR PMC4270131__F10 C-Terminal Module IV of Connective Tissue Growth Factor, Through EGFR/Nox1 Signaling, Activates the NFKB Pathway and Proinflammatory Factors in Vascular Smooth Muscle Cells NOXA1 EGFR PMC7285791__F4 Bioinformatics analysis of YRDC-mediated hub protein-protein interaction networks in NSCLC UTP6 PSMD12 PCNA PSMB3 DKC1 IMP4 ANAPC11 GNL2 ORC1L PRIM1 MRPL20 PSMD13 CCNE2 PSMD3 POLR2D RFC3 CCNB1 PMC6536578__F10 IPA network analyses of the 40 deregulated genes that we obtained from COMPARE analysis (see ) revealed the reconstruction of (A) NFKB network pathway and (B) HIF-1A network POMZP3 RPL17 CRELD1 FAM216A B4GALT4 PMC7824851__F4 PTEN modulates cell survival and proliferation by suppressing PI3K/Akt signaling AKT3 PTEN MDM2 MTOR PMC5789353__F1 Central pathway for fatty acid and cholesterol synthesis ACLY SCD FASN LDLR PMC5789353__F2 Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells GLUD1 ACSS2 CIC GLS SLC25A1 HEL-S-32 ME1 HEL-S-26 PMC7712612__F3 MIR22HG is involved in signaling pathways that affect cancer progression CDH2 STAT3 SNAI1 SMAD2 SMAD4 NOTCH2 CCND1 CTNNB1 PMC9294223__F8 Inhibition of Notch Signaling Stimulates Osteoclastogenesis From the Common Trilineage Progenitor Under Inflammatory Conditions CTSK PMC7479660__F4 Proposed mechanism by which losartan through Hsp70 inhibits the epithelial to mesenchymal transition (EMT) induced by angiotensin II in proximal tubule cells derived from SHR SMAD2 ARHA CTNNB1 PMC6594147__F1 Dysregulated immune response in the primary mediastinal B‐cell lymphoma (PMBCL) tumour microenvironment SOCS1 CD58 CD2 MHC2TA IL13 RELB IL4 CCR4 FOXP3 REL TNF CCL17 PMC8247262__F5 Metabolic model of Lipomyces starkeyi for predicting lipogenesis potential from diverse low-cost substrates MAL OMA1 CIT PMC7775270__F4 Musicians in the intrinsic pathway of apoptosis—a large ensemble BAX TXNIP GSK3B HRK PMC6917616__F3 Metabolic and transcriptional adaption in tissue Treg cells HPGD IL33 AHR FOXP3 GATA3 PMC4449706__F5 Simultaneous Inference of Cancer Pathways and Tumor Progression from Cross-Sectional Mutation Data PIK3CA EGFR PIK3C2G PIK3R2 SMAD2 PIK3R1 PIK3C2A BRAF SMAD4 PTEN FGFR2 RB1 MDM4 CDKN2A PIK3C2B FBXW7 CDK6 SOX9 CDKN2C NF1 FGFR1 ATM MDM2 HEL-S-26 CDK4 ACVR2A APC KRAS TCF7L2 PDGFRA FGFR3 PMC2667705__F7 Regulation of hepatic HNF4A expression by insulin: involvement of SREBPs and proposed liver impairments FAS HMGCR LDLR HEL-S-70p PMC7930983__F3 Integrin-dependent adhesion and tensile force mechanotransduction modulate cellular behavior CDC42 ARHA RAC1 PMC8318692__F2 Interleukin-17A (IL-17A): A silent amplifier of COVID-19 TH IL17RC IL8RB ACE2 CCL20 PMC1501017__F2 Different pathways involved in apoptosis BAX CASP9 CAD CASP3 APAF1 FADD PMC4885545__F5 Possible molecular targets whereby luteolin (Lut) inhibits the invasion of cancer cells CDC42 TG FAS HGF MDM2 MTOR VEGFA PMC6538876__F1 Potential implication of proprotein convertase subtilisin/kexin type 9 (PCSK9) in amyloid B (AB) clearance in Alzheimer’s disease (AD) PCSK9 CD36 APOE ABCA1 PMC5983574__F1 Invasion-related molecules in oral squamous cell carcinoma CDH2 CXCL9 CXCR3 GAL HGF EGFR FGFR1 MMP2 DSG3 PMC4885545__F2 Luteolin (Lut) modulates cancer cell cycle progression FLT3 IGF1 GSK3B IGF1R MTOR PSAP IRS1 PMC6331581__F5 Predicted metabolic pathways of phylotypes NkOx7-01 and NkOx7-02 C6 AMT COPA PMC2699904__F8 Schematic showing inter-relationships of clustered genes associated with fatty acid, lipid and lipoprotein homeostasis based on differentially-expressed genes identified in lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice STAT3 ACAT1 ACAT2 SQLE PEX19 PMVK FDFT1 ABCA1 PMC2699904__F7 Inter-relationships of genes associated with apoptosis differentially expressed in the lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice JUN CASP8 BCL2A1 MCL1 FASN MARK1 XBP1 SET TAF1 BCL2L2 CLU BCL2 BIRC2 BIRC3 PMC8212477__F4 Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (2): impacts of post-partum negative energy balance on stromal, glandular and luminal epithelial cells PLN ADAR HEL-S-79 PLCB4 IFIH1 CLDN3 PRKCZ CHRM3 HTR2A SOCS3 CCL2 SLC25A4 ADCY8 RYR3 MYLK STAT1 IFNGR2 ITPKA LLGL2 TACR1 ITPR2 MX1 CLDN23 GRIN1 PTGFR EIF2AK2 TJP3 PTGER3 P2RX3 CGN JUNB IRF7 TNF IGSF5 FOS ERBB3 JAK1 PMC11459742__F4 Modeling ncRNA interactions with signalling pathways using GO data TBK1 CGAS EGFR IRF3 MYD88 PMC6730590__F2 Effects of mutant Kras in reprogramming amino acid metabolism GLUD1 GOT2 HEL-S-32 ATF4 ME1 ASNS EIF2A KRAS PMC6028121__F4 Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment CDC42 APC CTNNB1 PMC3377831__F1 Biosynthesis and catabolism of melatonin CYP1A2 CYP2C19 AANAT CYP1B1 CYP1A1 AAAS PMC2679427__F1 Regulation of rat GSTA2 and NQO1 gene expression NQO1 AHR PMC3759481__F1 Simplified schematic shows the major intracellular signal transduction pathways that regulate the epithelial-to-mesenchymal transition (EMT) process in fibrotic kidneys APC GSK3B LRP5 HEL-S-28 LRP6 CTNNB1 PMC6834155__F4 Non-genomic actions of thyroid hormone PFKP MTOR PMC6061156__F1 Ag processing and presentation pathways followed by CPP-Ag in dendritic cells CD80 PMC2921989__F1 Regulation of Energy Metabolism and the IGF-1/mTOR Pathways by the p53 Protein BAX TSC2 IGF1 LIF CHMP4C PTEN TIGAR MDM2 MTOR GLS2 PMC4776187__F3 Modes of action of lipids in enterovirus replication RHEB GABARAP TSC1 MTOR PMC7522204__F5 In silico analysis indicating an inhibitory effect of Ambrisentan on PAR2 signaling pathway ARRB2 PGR EGFR SYNGR2 SRC PMC2921989__F2 Regulation of Energy Metabolism and the IGF-1/mTOR Pathways by the p53 Protein RHEB BAX MDM2 PDK2 PMC3209254__F9 The multiple mechanisms by which Sox2 regulates the osteoblast lineage BMI1 APC SOX2 GSK3B CTNNB1 PMC12155190__F1 NFKB signalling pathway leading to the expression of genes encoding inducible nitric oxide synthase (iNOS), interleukin-6 and adhesion molecules (i RELA VCAM1 PMC4070857__F2 The primary mechanisms through which vitamin D-regulated dendritic cells (DCs) and T-lymphocyte function.Notes: vitamin D precursors can be further processed to their active metabolite, 1,25(OH)2D3, in DCs and T lymphocytes NR1i1 CD40 IFNG CYP27B1 CD80 CCL22 PMC7415309__F7 Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the Development of Retinoblastoma by Modulating the MicroRNA-515/HOXA1/Wnt/Beta-Catenin Axis HOXA1 CTNNB1 PMC8693863__F7 ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion MYOG MYMK RAC1 PMC8065762__F5 Reductive stress in glutaminolysis GLS HEL-S-26 PMC6492945__F9 Schematic mechanism of Mac-1 regulation of human FOXP1 gene promoters and expression IRAK1 TRAF6 PMC12066304__F9 Genome-wide association study and transcriptomic analysis reveal the crucial role of sting1 in resistance to visceral white-nodules disease in Larimichthys polyactis TBK1 CGAS IRF3 IRF7 PMC4099309__F3 TNF and MAP kinase signaling pathways EEF2K EBP EEF2 TNF EIF4E PMC4099309__F2 TNF and MAP kinase signaling pathways CDC42 EEF2K DCX MAP3K7IP1 TRADD TNF TRAF2 FADD PMC9386726__F6 Ubiquitin-ligase TRAF6 and TGFB type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells TF APPL1 AURKB SMAD2 SMAD4 MMP2 MMP9 TRAF6 PMC6463562__F6 Proposed scheme for PAHSA synthesis ACLY MGST3 HEL-S-128m AIG1 BAAT FASN ADTRP MGST1 PMC2477698__F1 Examples of the molecular mechanisms by which phytochemicals activate hormetic stress response pathways NGF IGF1 KEAP1 BDNF SIRT1 PMC8393382__F4 Well-Known and Novel Players in Endothelial Dysfunction: Updates on a Notch(ed) Landscape TG ANGPTL3 CTNNB1 PMC6753107__F1 Schematic diagram of the BPV system based on a two-species microbial consortium with constrained electron flow NAPA CYB PC PMC7795776__F5 Predicted relationship between expressed and regulated genes within integrin, paxillin, and RhoGDI signaling pathways, and the consequent activation of diseases and biological functions in elderly individuals with T2D CDC42 GIT2 HEL114 PXN ARF6 HEL-S-28 RHO SRC PMC10743408__F3 Mechanistic illustration of downregulation of interferon-responsive genes and JAK/STAT1/2 signaling pathway STAT2 IRF9 IFIT1 IFIT3 IFIT2 IRF1 RSAD2 ISG20 STAT1 IFNAR2 IFNAR1 MX1 ISG15 JAK1 TYK2 OAS2 PMC12121985__F2 EGR transcription factors are essential in the functional regulation of T cells EGR1 LAT NAB2 GRB2 EGR2 PMC8619695__F4 Protein Misfolding and Aggregation: The Relatedness between Parkinson’s Disease and Hepatic Endoplasmic Reticulum Storage Disorders EIF2A XBP1 PMC7599628__F4 Initial immune response to any pathogen involves the activation of innate immunity TLR1 CGAS MAVS IL16 TLR4 TLR9 TLR8 TLR5 TLR7 TLR10 MYD88 PMC4422811__F2 Survival signaling vs EGF BAD FOXO4 FOXO1 FOXO3A EGFR BCL2 PMC6116115__F2 Polymerase-related genes identified using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis LIG1 DNA2 FEN1 PCNA PMC6993408__F6 LSS-triggered VEGF-ATOH8 signal axis mediates CRC m-CTCs survival HK2 ATOH8 PMC4256275__F11 RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities ALDH1A3 TBX1 FGF5C PMC7528506__F1 Homologues recombinant DNA repair system RAD50 RAD51 MRE11A BRCA1 H2AX BRCA2 RNF8 ATM USP21 PALB2 PMC6506535__F6 T helper cell differentiation pathway of MAIT cells in comparison with conventional T cells CD40 STAT3 TH CD80 TGFBR3 IL2RA IL21R GATA3 TGFBR1 IL-21 TGFBR2 ICOS STAT4 FOXP3 IL23R BCL6 PMC2908764__F3 Molecular cues controlling the pathway choices at the Drosophila and vertebrate midline KIT SEMA3B PMC8650508__F6 Salvianolic acid B targets mortalin and inhibits the migration and invasion of hepatocellular carcinoma via the RECK/STAT3 pathway CDH2 STAT3 RECK MMP2 MMP9 PMC6506535__F5 Natural killer cell signaling pathway of MAIT cells in comparison with conventional T cells ZAP70 LAT GRB2 LCK PMC6506535__F4 Role of macrophage, fibroblast and endothelial cell pathways in MAIT cells SOCS1 STAT3 IL17RC IL17RA LTBR RELA SOCS3 TNF MYD88 PMC6873406__F10 Non small cell lung cancer pathway circuit STAT3 EGF BAD RASSF1 EGFR JAK3 ERBB2 PTEN GRB2 KRAS CCND1 PMC10454700__F4 Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells CDC42 MAP3K7IP1 IGF1 IL6 DLX5 RUNX2 INS PMC10454700__F3 Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells HDAC1 BMP2 LRP5 CTNNB1 PMC3861057__F8 Transcriptional changes in the WNT signaling pathway of E11.5 Sost–/–; Sostdc1–/– limbs CDC42 DVL1 WNT3A NFATC2 GSK3B RYK TCF4 MTOR MYC RUNX2 CTNNB1 BCL9 SOST CDK6 SOSTDC1 CCND2 DKK1 SOX1 CTBP1 WNT7A CSNK1G1 CSNK1A1 DKK2 CCND1 TCF12 ID2 CSNK1D APC LRP5 LRP6 ARHA AXIN2 CD44 DKK3 TSC2 TSC1 AXIN1 MAP3K7 NLK LEF1 GJA1 PMC4148086__F1 Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): An oncoprotein with many hands CIP2A FOXO1 COIL PPP2R1A MDM2 CTNNB1 EIF4E PMC12154233__F5 FSL-1 protects against radiation-induced damage through the TLR signaling pathway TLR9 TLR8 TLR5 MYD88 PMC3345303__F2 Neural and Cellular Mechanisms of Fear and Extinction Memory Formation ARC MTOR BDNF HEL-S-30 PMC3977151__F1 GOLGI IN COPPER HOMEOSTASIS: A VIEW FROM THE MEMBRANE TRAFFICKING FIELD ATOX1 CCS ATP7B COX17 ATP7A PMC7144730__F5 EVO downregulates HGF-induced c-Met/Src/STAT3 phosphorylation and causes apoptosis through blocking the c-Met signaling pathway STAT3 HGF SRC PMC11591922__F3 Mechanisms by which fasting or fasting-mimicking diets kill cancer cells in solid tumors ATG101 SIRT3 IGF1 FOXO1 ULK1 IGF1R MTOR PMC6873406__F13 Non small cell lung cancer pathway logic circuit with miRNA EGF ERBB2 PTEN GRB2 PMC6599195__F3 Signaling pathway downstream of TLR4 receptor in platelets with related cellular events and their regulatory miRNAs* SNAP23 VASP TIRAP TLR4 GC CD14 TRAF6 IRAK4 MYD88 PMC4720884__F8 Hypothetical model of the signaling pathway through which MIF is involved in ConA-induced autophagic cell death of hepatoma cells STAT3 BNIP3 MIF PMC5775265__F4 Differential effects of HBZ on the Jun family proteins JUND SP1 JUNB RPS25 PMC7415235__F2 Key pathways involved in foam cell formation regulated by microRNA ABCG1 NLRP3 CD36 TRAF6 MYD88 PMC10631767__F2 Associations between CCA, TAMs and TANs STAT3 IL10 OSM IL11 VEGFA PMC10631767__F1 Interactions between CAFs and CCA cells STAT3 PDGFD VEGFC HBEGF HGF EGFR VEGFA CXCR4 PMC2713346__F1 Crz1 enters the nucleus in short stochastic bursts lasting about 2 min after undergoing dephosphorylation in the cytoplasm by the calcium-activated phosphatase calcineurin (Cn) (, ) NFATC4 DYRK1A NFATC2 NFATC1 SRR NFATC3 REL PMC5857600__F5 Alterations in the mammalian Hippo signaling pathway alter FLNA phosphorylation LATS1 FAT4 MOB2 LATS2 DCHS1 PMC6295143__F2 TREM2 molecular signaling in microglia, initiating phagocytosis and microglial survival or modulating proinflammatory response, is not well characterized so only validated components are displayed TREM2 SYK TLR4 PMC8486294__F7 CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion TRO HEL113 CXCL5 IL8RB PMC4107458__F1 Neutrophil derived S100a8/S100a9 protein potentially contributing hypertensive cardiac fibrosis induced by Ang II TLR4 S100A8 S100A9 MPO PMC9267440__F1 Identification of Genetic Variations in the NAD-Related Pathways for Patients with Major Depressive Disorder: A Case-Control Study in Taiwan NRK NAPRT HEL-S-90n KYNU KMO HAAO NAMPT AFMID ALDH8A1 PMC5412052__F6 IPA generated pathway prediction for the NRF2-mediated oxidative stress response in the small intestine JUN AOX1 HEL-S-107 PPIB HEL-S-94n VCP GPX2 TXN FTH1 BACH1 CCT7 FTL EPHX1 NFKBIA CLPP ATF4 HEL-75 UBB PMC6309361__F2 Effects of hemolysis on the monocyte/macrophage compartment CDC42 SPIC DOCK8 BACH1 PMC5412052__F5 Combined gene expression and predicted activation information for the mTOR pathway in the heart and small intestine EIF4B RAF1 RPSA SREBF2 PTEN RHO EIF4E RHEB TSC2 TSC1 INSR PC ELF3 PMC4975578__F2 Immunopathogenesis and Therapeutic Approaches in Pediatric Celiac Disease IL15 IFNG TH JAK3 MICA PMC6056039__F1 Calcineurin pathway in T cells and amplification of NFATc1/A ZAP70 LAT MAF IL2 ITK NFATC1 FOS PMC4463189__F1 Targeting cancer with kinase inhibitors ATR MAP4K1 BRAF KIT MTOR CTLA4 MERTK RIPK3 PAK1 ROCK1 CSK ATM CCND1 CSF1R PMC7866294__F1 Cellular ganglioside metabolism and structure of GD2 UGCG GAL B4GALNT1 B3GALT4 PMC4989157__F7 HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling ARID1A WEE1 CDC25B PMC7006128__F6 Innate immune system pathways showing Native American ancestry enrichment CCL3L3 CCL3 TLR9 CD14 AIM2 CXCL10 IRAK4 MYD88 IFNK LY96 TLR4 ISG15 LBP PMC4420468__F6 Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells LIF IRAK2 TCF4 IL6 WNT7B ITGAV TFRC NEDD4 KPNA3 PLCB2 SH3GL1 SH3GLB2 LEF1 FMO4 PMC11524014__F3 Carbon dots in anticancer immunotherapy CD80 HEL70 IL6 CRBN IL1B PMC8395128__F3 Regulatory Role of microRNAs Targeting the Transcription Co-Factor ZNF521 in Normal Tissues and Cancers ZNF521 RUNX2 PMC5698910__F1 Bile acid synthesis, signaling, and regulation in human liver FGF8A CYP8B1 S1PR2 CH25H CYP46A1 CYP7B1 CYP27A1 PMC9322659__F8 Comparing Transcriptomes Reveals Key Metabolic Mechanisms in Superior Growth Performance Nile Tilapia (Oreochromis niloticus) CYP2R1 AKR1D1 CYP8B1 ACAT2 EBP DHCR7 CYP46A1 IDI1 HSD17B12 PMC6158479__F2 Protective function of the calcium-sensing receptor against inflammation and carcinogenesis in the colon CASR ROR2 SOX2 CTNNB1 PMC8455326__F4 Proposed gut–brain pathways mediating postoral sugar and fat appetition in mice NTS FAS BLM PMC4632778__F10 Schema of osteogenic differentiation through the BMP signaling pathway and possible regulation by PARP activity SMAD1 DKFZp781O1323 BMP2 SMAD4 RUNX2 PMC4429004__F4 Functional prions in immune signaling MAVS NWD2 NLRP3 PMC9322659__F7 Comparing Transcriptomes Reveals Key Metabolic Mechanisms in Superior Growth Performance Nile Tilapia (Oreochromis niloticus) ACLY FASN ACADVL SIRT1 PMC5705453__F2 The role of ASK1 in endothelial cell BAX TNF PMC6452649__F7 Schematic model depicting RARA’s involvement in regulation of intracellular signaling, protein synthesis, and synaptic plasticity in postsynaptic neurons RHEB RARA TSC2 TSC1 PMC11547089__F10 Expression of genes involved in AsA biosynthesis in L INPP1 MIOX PMC9368002__F1 Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells CD40 RGS2 ELOVL2 PHKA1 CXCL12 NR1H3 ACSL3 NGFR IGFBP2 VEGFA GREM2 CXCL10 C3orf57 S1PR3 PNPLA3 MOG APP GAD2 KLF5 WNT4 CYP7B1 KDR SERINC2 PMC7482219__F1 Mesoderm patterning by a dynamic gradient of retinoic acid signalling FGF7A ALDH1A2 NODAL CYP26A1 FGF8 PMC11667808__F5 PI3K/AKT/mTOR, JAK/STAT3 and Rho pathway in optic nerve axon regeneration STAT3 TSC2 TSC1 LINGO1 PTEN SOCS3 RHO MTOR EIF4E PMC8631454__F8 Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice GSDMD NLRP3 IL1B PMC7911348__F1 TOR Signaling Pathway in Cardiac Aging and Heart Failure ULK1 DEPTOR EIF4E PMC9572851__F9 Torularhodin Alleviates Hepatic Dyslipidemia and Inflammations in High-Fat Diet-Induced Obese Mice via PPARA Signaling Pathway HEL-S-22 STAT3 FAS ASL BDH1 FABP1 HEL111 FAF1 SLC27A2 PCK1 ECI2 SLC27A5 PLIN4 ACAT1 APOA4 GSDMD INSR CYP7A1 ROCK1 LSR OPTN BAX ABCB11 ME1 PTK2B MIF YAP1 APOA2 FABP5 EPHX1 APEX1 FABP2 ABCB4 CASP3 ADFP SLC27A4 CPT1A FADD PMC5515284__F7 CanProVar 2.0: an Updated Database of Human Cancer Proteome Variation RFWD2 TSC2 ATR BAD FAS PERP CASP3 CDK2 ATM PTEN MDM2 MYC PMC7565917__F4 Hypothetical steps leading to the disassembly of NETs DNASE1L3 VWF TLR4 TLR9 CLEC2D TREX1 MYD88 PMC8507062__F3 Crucial role for the long non-coding RNA CASC11 in the pathogenesis of human cancers EZH2 PTEN HNRNPK CTNNB1 PMC5040984__F1 Patents and clinical trials involving the Wnt signaling pathway TNKS APC GPR49 CTNNB1 PMC3930365__F6 Second ranked network of genes altered in the newborn lung at 24h post-O3 exposure CHADL NUP155 ZW10 TRO CENPN ESCO2 BYSL CENPK MIS18BP1 KNTC1 DAP GPS2 GOLPH2 PMC3930365__F5 Top ranked network of genes altered in the newborn lung at 24h post-O3 exposure CDCA2 KIF15 DBF4 MTHFD2 DLGAP5 APC KNTC2 CENPE MKI67 FANCD2 TACC3 CCNE1 BRCA1 CDC45 STIL UHRF1 PMC6363221__F9 Systems biology reveals how altered TGFB signalling with age reduces protection against pro-inflammatory stimuli TLR1 SMAD1 DKFZp781O1323 C1QA ITGB4 TLR4 SMAD2 JAG2 C1QB CD84 EGFL7 PMC7724003__F7 Nucleus accumbens-deep brain stimulation (NAc-DBS) alters neural excitability by modulating neuronal signaling pathways TES GAA REN PMC5992605__F7 Schematic model describing the molecular responses to SIL1 loss in skeletal muscles leading to myopathy SIL1 IGF1R MTOR GADD45A PMC8201103__F7 Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines BAX PHB2 ATF4 EIF2A XBP1 PMC8411238__F6 Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses TSC2 HIF1A MTOR PMC6521842__F9 A putative signaling pathway of ERK5/ankrd1 for promoting catecholamine biosynthesis TH NGF ANKRD1 PMC8334350__F2 Schematic models for combinatorial C. elegans and mammalian system studies regarding the role of insulin/IGF-1 signaling, mTOR pathway, and sirtuins ERCC1 EFL1 MTOR PMC5700831__F8 Depicting the possible molecular mechansims by which MitoQ prevents alcoholic liver disease through modulating ALDH2 posttranslational modifications ALDH2 TLR4 NOX4 PMC7118243__F2 Activation and inhibition pathways for ILC2s VIP IL25 STAT1 ADRB2 NMU TNF PMC2892252__F1 Host responses to Candida albicans: Th17 cells and mucosal candidiasis STAT3 IL17A IL1B PMC6053273__F5 The neurogenic activity of (2R,6R)-hydroxynorketamine TSC2 NGF BCL2 EEF2 BDNF PMC6498619__F3 Evolutionary conservation of the IIS pathway RHEB TSC2 TSC1 FOXO4 IGF1 FOXO1 FOXO3A F3 INS PMC3082642__F3 HBOT affects gene expression in the Nrf2 Pathway ATR JUN PMC5796148__F1 Change in the metabolism of adenosine signaling between the states of healthy and infected PANX1 ADA PMC6131422__F1 Substrates involved in caffeine biosynthesis pathways and its other related pathways catalysed by enzymes that were encoded by genes carrying the TAVs identified from this study TH GIP PMC2895966__F2 Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target CASP9 FAS CASP8 CASP3 TNF TRAF2 FADD PMC7997388__F1 The human complement system C6 CD59 FH C7 C5AR2 HEL-S-62p C2 C9 CR2 C4B_2 CP PMC6556902__F3 Significant pathways identified using Tied Diffusion through Interacting Events method, an approach that can extract the most likely set of interconnectors between two sets of nodes PRLR SOCS1 IFNA7 IFNA6 KIF3A OSM IL3 JAK3 IL33 IRAK1 IL21R HLA-DPB1 CCL2 MYD88 IL-21 IFNG IL16 OSMR IF2D PDE4D NPY IL18RAP IKZF3 HEL-S-44 NOS2 TIMP3 RAD50 CSF2 CASP8 IL18R1 TIMELESS MMP10 IFNA21 IL1A VEGFA TNF IL1RN EDN1 ADRB2 BCL2 THPO IL23R IL15 TGFB1 ERCC2 IFNL3 NFKB2 HLA-DRB1 IL2RA PPP2CA GH1 PDE4B IL11RA CSF3 TBX21 MPL IL1R2 IL1R1 IFNGR2 CSF2RB HLA-G IRAK3 IL18 IL2 IL1RL2 IL9 IL10 IL12A IL1RAPL1 CCL11 CSH2 IL13 CD14 SIGIRR MMP9 HLA-DQB1 PARP1 SLA2 IL24 PRL CD2AP CAMK2D CFTR IL6ST IL7 TYK2 IL23A PMC3117879__F2 Implications of Relationships between Human Diseases and Metabolic Subpathways TERT PAH PMC6556902__F2 Analysis of severe asthma differential expression gene signature in the context of STRING protein association network IL20RB FLT3 IL19 NPHS2 ATR SMAD1 PTK6 CLSPN SEMA3E SFN PTEN KCNN4 KHDRBS1 BLM IL22RA1 STAP2 IL1R2 RAPSN AGRN FYN WNK4 YWHAQ KHDRBS2 IF2D NOG BMP4 CRY2 IL18 HEL-S-1 KRT73 HEL2 YWHAG IL1B CPXM1 MATK ACVR2B SYT13 HEL-S-28 PLXND1 BMP6 FHOD1 HSD17B13 CHEK1 CALM1 BMP5 MCM2 MAP3K6 YWHAZ PMC6556902__F1 Examples of representations for contextualizing disease associated genes HSD17B4 HLA-DMB PYCARD LTC4S GPX4 NCF2 GPX1 PNLIP GPX2 BTK TGFBRAP1 APEX1 ALOXE3 IKZF3 PMC12002712__F1 Biosynthetic pathway of D-tocotrienol in Y HPD IPP IDI1 PMC3595017__F1 Caspase-8 and FLIP regulate RIG-I/MDA5-induced innate immune host responses to picornaviruses MAVS TRADD TANK IRF3 IRF7 FADD PMC8397082__F1 Cardiac Neural Crest Cells in Heart Development and Congenital Heart Defects FOXC2 FOXE1 BMPR1A CTDNEP1 TBX1 FOXC1 SMAD4 TGIF1 HAND2 PITX2 PMC7553077__F2 Recent advances in engineering different immune cell types for immunotherapy applications CD40 ADORA2A NTN1 BACH2 PRDM1 CCR5 CD7 PTEN B2M IRF4 CDK5 ADAM17 PAX5 CD33 HEL-S-171mP LAG3 PMC3309939__F8 Identification of a Novel Signaling Pathway and Its Relevance for GluA1 Recycling PI3 PIKFYVE PMC8313992__F10 Acute TBK1/IKKE Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury IFNG IL19 TBK1 CSF1 IL33 TMEM119 CD68 PMC8353181__F3 Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver Disease CXCL12 MSC CXCR4 PMC11007064__F6 Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNA production CDKN2A CGAS IRF3 GATA4 PMC7594023__F1 Pathway analysis map showing VEGF signaling via VEGFR-2 generic cascades CDC42 MAPK1 JUN COX1 NCK1 PLAUR MAPKAPK2 TCF4 PTGS2 VEGFA ARHA CCL2 RAC1 CTNNB1 MAPK3 HRAS SHB ROCK1 GRB2 SRC CREB1 PMC4867603__F4 Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet ACLY ACSS2 PDHA1 FASN ABHD5 ACACA PMC6156233__F6 Graphical Abstract RPE IL10 TLR4 GC IL18 PMC8747665__F7 Preventive Effect of Anemarrhenae rhizome and Phellodendri cortex on Danazol-Induced in Precocious Puberty in Female Rats and Network Pharmacological Analysis of Active Compounds POR BMP15 BMP6 INSR COX2 LDLR MMP2 FSHR PMC7032926__F9 Proposed model of TLR5-TLR4 interaction during environmental lung injury TLR4 TLR5 MYD88 PMC3932023__F2 Exosome secretion in a cancer cell model RAB27A RAB27B RAB5A RAB13 RAB9A PMC6449901__F4 Summary of genes involved in the glycolate production pathway MAL DAP CIT PMC3175442__F4 Map of cytoskeleton remodeling pathway (Genego Metacore, fragment) overlapped with quantile-normalized estimations of protein abundance MAPK1 HRAS LIMK2 LIMK1 GSK3B HEL-S-28 GRB2 CTNNB1 PMC8593216__F6 APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells ATR PCNA GEM PMC3175442__F2 Map of pentose phosphate pathway (Genego Metacore) overlapped with quantile-normalized estimations of protein abundance HEL107 RPE RPIA PMC7202972__SF1 Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice STAT5B GHR PMC8018932__F8 Proposed model of mToxin effects in the brain of AD mice (with emphasis upon A7AChR function) BACE1 NACA2 NACA PMC2964177__F1 ErbB2 cellular signaling pathways and lapatinib mechanism of action ERBB2 PTEN MTOR PMC9095829__F8 TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases CLDN3 ATF4 XBP1 PMC9510782__F6 Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein STAT3 TLR4 S100A8 DOK3 MYD88 PMC3488313__F4 Proposed mechanism of associated vWF activating GPIIb/IIIA VWF PLCG2 PMC4812578__F1 PI3K/AKT signaling pathway RHEB TSC1 PTEN MDM2 CCND1 MERTK PMC7190223__F1 Components of canonical hippo signaling pathway LATS1 LATS2 PMC3259514__F1 Different signaling pathways leading to the induction of virus stress-inducible genes (VSIGs) and interferon-stimulated genes (ISGs) TBK1 STAT1 MAP3K7IP1 STAT2 IRF9 IRAK1 IRF1 IRF3 ATF2 JAK1 TRAF6 IRAK4 PMC6104630__F2 (B–catenin mediated) Wnt signaling pathway APC GSK3B SP5 PMC4168074__F1 Model proposed by Rakoff-Nahoum et al TLR4 MYD88 PMC7047286__F4 Tdh- and tRNA synthetases-derived origins of AI-3 analogs MB PMC5595144__F2 Dendritic cells (DC) can either activate adaptive immunity or tolerize T cells depending on their state of maturation STAT3 BTLA LAG3 PMC9471148__F2 An overview of agents and treatments for PDGFRA-mutated gastrointestinal stromal tumors STAT3 STAT1 STAT2 NF1 PDGFRA BRAF KIT MTOR PMC4683003__F1 Acetyl-Phosphate Is Not a Global Regulatory Bridge between Virulence and Central Metabolism in Borrelia burgdorferi PMVK IDI1 MVK PMC7266663__F7 Strontium-substituted sub-micron bioactive glasses inhibit ostoclastogenesis through suppression of RANKL-induced signaling pathway SI NFATC1 TRAF6 PMC8220689__F6 Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers PMC8220689__F5 Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers CTNNBIP1 CTNNB1 PMC3378042__F2 Implications of Protein Post-translational Modifications in IBD TLR4 NUB1 IL6 FADD PMC8529925__F1 Molecular testing for colorectal cancer: Clinical applications EGF EGFR PTEN MTOR PMC11676931__F5 Nerelimomab alleviates capsaicin-induced acute lung injury by inhibiting the TNF signaling pathway and apoptosis in vivo and in vitro; (some of the material is from Figdraw https://www BAX TNF PMC7997318__F6 Nrf2 pathway in different liver diseases KEAP1 MAF PMC9139203__F1 Molecular Characterization of BRCA1 c.5339T>C Missense Mutation in DNA Damage Response of Triple-Negative Breast Cancer RAD50 RAD51 MRE11A BRCA1 BRCA2 ATM PALB2 PMC5576943__F2 Complement activation pathways and allograft immunity MASP1 HEL-S-62p C1S APC CR2 PMC11120013__F2 Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer EGF HBEGF KEAP1 NQO1 CP PMC11120013__F4 CP-derived RONS promote cancer cell autophagy and death by activating the mitogen-activated protein kinase (MAPK) family signalling pathways BAX BCL2 DFNA5 ATG5 CP PMC7767423__F1 Fatty acid mobilization and utilization in skeletal muscle during endurance exercise LPL CPT2 PMC5499156__F1 Proteins that interact directly or indirectly with mGlu1/5 receptors and mediate receptor signalling TAMALIN PI3 MTOR PMC6005849__F7 PI3K–AKT pathway perturbation in response to treatment of interleukin (IL)-6 stimulated osteoblasts with resolvin E1 (RvE1) EIF4B BAD RAF1 EBP ELL RBL2 PTEN CD19 MTOR RAC1 EIF4E RHEB TSC2 BCR MEI1 PIR MDM2 PMC10999569__F3 PIAS family in cancer: from basic mechanisms to clinical applications PIAS1 TNF PMC9170726__F8 Fas/FasL regulating mROS and IFNG production after IL-12/IL-18 stimulation FAS STAT4 PMC5535714__F3 Redox regulation of Wnt/Beta-catenin signaling pathway and lipid peroxidation APC GSK3B CCND1 RAC1 CTNNB1 PMC8466912__F3 Inhibition of Cellular and Animal Inflammatory Disease Models by NFKB Inhibitor DHMEQ TRAF6 TRAF2 IL1B PMC9220248__F2 Chronic Rhinosinusitis, S. aureus Biofilm and Secreted Products, Inflammatory Responses, and Disease Severity IL25 TSLP IL33 PLG PMC9356782__F6 Renshen Baidu Powder Attenuated Intestinal Inflammation and Apoptosis in Ulcerative Colitis Rats through the Inhibition of PI3K/AKT/NFKB Signaling Pathway TSC2 BAD CD37 RBL2 CD19 PTEN HEL-S-11 PMC8624111__F10 Design, Synthesis and Evaluation of Novel Derivatives of Curcuminoids with Cytotoxicity RFWD2 CASP9 ATR CD2 PTEN MTOR MYC TSC2 CASP3 CDK2 ATM PIGS MDM2 APAF1 PMC8468056__F6 GPR30 Activation by 17Beta-Estradiol Promotes p62 Phosphorylation and Increases Estrogen Receptor A Protein Expression by Inducing Its Release from a Complex Formed with KEAP1 KEAP1 EGFR MTOR SRC PMC3623255__F3 Metabolic pathways in the periplasm and the cytoplasm PGP GAD2 PPL PMC3623255__F2 Mass isotopomer labeling measurements of intracellular metabolites (red bars, after 8.0 h in growth phase I; green bars, after 14.25 h in growth phase II) arranged by pathways: fractional abundance over mass in context of the metabolic network RPE PGP GNE MAL GLA TNLG7C PMC4350260__F1 NFKB and STAT3 in Glioblastoma: Therapeutic Targets Coming of Age STAT3 ING4 TRADD EZH2 SOCS3 MTOR JAK1 VEGFA PIN1 PMC6315409__F3 Biosynthetic pathway for very-long-chain fatty acids (VLCFA), the dicarboxylic acid 20:4 (DCA 20:4), and the very-long-chain dicarboxylic acid 28:4 (VLDCA 28:4) ELOVL4 ELOVL3 ELOVL2 ELOVL1 ELOVL5 PMC4091980__F1 Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain CASP9 BAD PTEN MDM2 MTOR PMC6158396__F3 HMGB1 signaling pathway in cerebrovascular disease HMGB1 IL1B PMC4280670__F3 New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication ATF4 EIF2A PMC7009407__F7 Schematic and simplified diagram of some salient features of AHR signalling pathways Black solid arrows depict the canonical pathway, dashed arrows alternative pathways, and the red solid arrow an example of their intersection COX2 APP AHRR CTNNB1 PMC9139203__F8 Molecular Characterization of BRCA1 c.5339T>C Missense Mutation in DNA Damage Response of Triple-Negative Breast Cancer RAD51 BRCA1 BRCA2 ATM PALB2 PMC3241972__F1 TOR in the immune system RHEB MLST8 TSC2 RICTOR TSC1 MTOR DEPTOR EIF4E PMC7793734__F7 Hypothesized mechanism by which endothelial cells promote docetaxel resistance of prostate cancer cells ELL PC ERG MTOR FGF2 PMC8750110__F5 Physical Forces and Transient Nuclear Envelope Rupture during Metastasis: The Key for Success? CGAS IRF3 TNF ENPP1 PMC5517472__F3 Overview of the metabolism of hepatic methylamine TG PEMT HEL-S-61p PMC7475009__F1 Based on WGCNA, we explored the correlations among gene modules and all possible variables, with particular interest in those related to age STAT3 PRMT3 IGF1 BCR CD72 GC CD22 CD19 LYN INS PMC4177745__F9 GLD-4-Mediated Translational Activation Regulates the Size of the Proliferative Germ Cell Pool in the Adult C. elegans Germ Line STAR GID4 PMC2816169__F6 Prokineticin (PROK1) induction of regulator of calcineurin 1 isoform 4 (RCAN1-4) and interleukin (IL-11) PROK1 RCAN1 PROKR1 RCAN3 PMC10311568__F2 Research progress of sophoridine’s pharmacological activities and its molecular mechanism: an updated review CDK2 PTEN NR3B3 CTNNB1 PMC7868826__F4 EGF induced A20 expression via the MEK1/MSK1/p-p65 (Ser276) signaling pathway EGF HEL-S-162eP TNF PMC4280670__F1 New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication EGFR PDGFRA PTEN GRB2 TRAF6 PMC4807283__F1 CerS are central enzymes in the sphingolipid metabolism pathway CERS3 CERS5 CERS1 CERS2 KDSR CERS6 PMC4344863__F1 Input overload: contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis CRABP2 LRAT RBP4 RDH10 ALDH1A2 DHRS3 PMC6044101__F6 Spleen regulatory networks EGF GIP SCG3 MYC NPTXR IFNG YOD1 BTRC CNN2 HRK ABCB9 HTT ASB1 FBLN7 SBNO2 CHST11 SLC25A21 ZNF786 POLE2 KRTAP10-3 KCTD7 ARL4A RRM2 ZPR1 TMIE ARPP19 SLC6A20 BCL2 SLC16A10 HCTP4 BSDC1 PMC7558103__F1 The nicotinamide adenine dinucleotide (NAD) metabolism NAPRT NMNAT1 NAMPT NMNAT2 NMNAT3 PMC4496332__F2 Dendritic spine dysgenesis in Autism Related Disorders RHEB UBE3A TSC2 TSC1 PTEN ARC MTOR BDNF RCAN1 EIF4E PMC10674583__F1 Nrf2-keap1/ARE signaling pathway KEAP1 NQO1 MAF PMC4631372__F4 Computational Characterization of Exogenous MicroRNAs that Can Be Transferred into Human Circulation HEL-S-103 RPS6KA2 NRP1 AACS CACNA1G MAP2K4 FGF9 PDGFC FGFR1 ITGA6 EPHA3 PPM1B RDX OXCT1 MAP4K3 ITGA4 HEL70 FGF2 PDHA1 IKBKB L2HGDH CSK CACNB4 PFN2 NLK CXCR4 PMC4445567__F5 Upregulated and downregulated genes in the cell cycle pathway after expansion in serum-free medium CDC2 PCNA C2 SMAD4 CDK2 MYT1 PMC5681673__F4 UV-induced H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway RNF168 RNF8 HUWE1 PMC4366432__F1 Epidermal growth factor receptor pathway EGFR BRAF MTOR PMC7517358__F3 Genetic networks associated with genes differentially expressed between radiosensitive and radioresistant gastric cancer (GC) cell lines PDPN PCDH10 NTS ACSL3 HEL-S-53e IL3 MYF5 FHL2 HIF1A SNURF PMAIP1 ITGB6 COXFA4L3 LOX FOXO4 CD74 KLF9 MDM2 ANTXR2 TIMP3 SEC23A FOSB ID2 MXD1 TMSB15B MAGEA11 EZH2 IRF3 S100P ZDHHC11 CRK RPS20 PRG2 GABRA2 NAB2 ADAM10 GYPC LCN2 HBE1 BIK S100B ENC1 HSD17B4 OLFM4 CSRP2 RRAD UBE2L6 TNFSF8 CDKN2B TNFRSF8 CCNG1 CCND2 CBLC NOD2 WTAP FHL1 NOD1 IL11 MXI1 IL27RA HMGB1 TLE3 KYNU EPHB6 PTPRK PCTK1 SFRP1 ID3 HOXD10 RAB20 TFPI2 PTPN22 NR2A1 HOXD11 FCGR3A CAMK2G CLDN1 PMC7403995__F7 Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes VWF SYK BTK FYN PLCG2 LAT PI3 LYN RAC1 PMC5810588__F1 Reciprocity in ROS and autophagic signaling HMGB1 ATG16L1 TXNIP ULK1 PTEN ATG10 ATG3 CAMKK2 ATG12 PI3 TFEB ATM OPTN ATG5 PMC2903791__F11 Cell signaling model for the regulation of glucose metabolism in hepatocytes by taurocholate EGFR SRC IRS1 PMC4631976__F1 Death resistance signaling in cancer cells RIPK3 BAX BAD TRADD MLKL RIPK1 FADD PMC9266893__F2 Iron, Neuroinflammation and Neurodegeneration ERFE BMP6 TFR2 EPO HFE IL6 HFE2 PMC2950751__F9 Summary schematic illustrating the adaptations of select genes of the IGF-1/PI3K/Akt pathway involved in protein synthesis and degradation analyzed in the plantaris muscle SMAD2 MTOR IRS1 PMC4131167__F7 Differential dependency network presented over the KEGG] apoptosis pathway BAD TRADD IL3 ATM TRAF2 FADD PMC4131167__F6 Rewiring of apoptosis pathway in breast cancer patients with and without recurrence BAX BAD CSF2RB PIK3R5 NFKB1 PPP3R1 IRAK3 NTRK1 CASP3 TNF IL1B PMC8247606__F2 Biological underpinnings of therapeutic resistance in pancreatic cancer KEAP1 ME1 KRAS PMC6291713__F8 JAK2 overexpression alleviates C2C12 myoblasts I/R injury through the AKT and ERK1/2 pathway IFNG STAT3 BAD BCL2 MTOR TYK2 PMC5997144__F2 P-Rex1 acts as a convergence point for pro-oncogenic/metastatic pathways PREX1 HRG HIF1A CXCR4 PMC11663741__F7 Protein-protein interaction networks were analyzed among differentially abundant proteins FLT3 STAT3 ZAP70 CD79B SERPINF2 NFATC2 PIK3CD PPP3R1 CTNND1 GNG12 C1QB MAPK8 DOCK2 PLCG2 WAS CCR1 VWF ARRB2 MASP2 CFD HMCN2 IRF4 CLEC4E PRF1 ITGB1 ITGA1 C1QC LYN RRAS2 CARD9 PMC2736328__F2 Transcriptional regulation of cytokine function in airway smooth muscle cells SYK TRADD BCL10 TRAF5 TRAF3 SRC TNF TRAF2 IRAK4 PMC4966762__F1 Signaling pathways activated by ET-1 in cancer COX1 COX2 EGFR GSK3B HEL-S-28 ARHA SRC CTNNB1 PMC8764238__F3 Molecular Mechanism of Puerarin Against Diabetes and its Complications BAX FOXO1 GSK3B MDM2 IRS1 PMC10546030__F2 Methionine biosynthesis and metabolism: Diagram of metabolic pathway showing aspartate family pathway, metabolism of methionine and cysteine biosynthesis DHPS PMC6266939__F1 Main components of the Hippo pathway and the current Hippo-targeted inhibitors discussed in this review CDC2 AMOT HEL-S-28 RHO PMC8307460__F1 RelB and Neuroinflammation LTB RELB TRAF3 IL1B PMC10756743__F6 Transcription Analysis of the THBS2 Gene through Regulation by Potential Noncoding Diagnostic Biomarkers and Oncogenes of Gastric Cancer in the ECM-Receptor Interaction Signaling Pathway: Integrated System Biology and Experimental Investigation ITGB1 THBS2 ADAMTS5 MMP2 ADAMTSL1 ADAMTS12 ADAMTS2 CD47 PMC10756743__F5 Transcription Analysis of the THBS2 Gene through Regulation by Potential Noncoding Diagnostic Biomarkers and Oncogenes of Gastric Cancer in the ECM-Receptor Interaction Signaling Pathway: Integrated System Biology and Experimental Investigation THBS2 PMC4017641__F1 O-glycan biosynthesis/human version pathway GALNT3 GALNT1 GALNT5 GALNT4 GCNT2 GCNT3 GALNT7 PMC9082421__F4 Transcriptome and iTRAQ-Based Proteome Reveal the Molecular Mechanism of Intestinal Injury Induced by Weaning Ewe's Milk in Lambs EHHADH MS4A1 AOX1 ACSL5 FABP1 SCD CD22 CR2 SLC48A1 CYP1A1 TFRC OLR1 DBI ADFP RDH12 PMC8430316__F2 Molecular mechanisms contributing to the formation of cancer-associated adipocytes STAT3 PDE3B SOCS3 MYC MMP11 PMC4466442__F2 Pathologic role of TCR, BCR and TH17-induced MALT-1 in demyelination and the inhibition of this signaling pathway by A20 BCL10 BCR RELB CYLD PMC3834519__F10 FXR/NR1H4 gene NR1H4 MAPK1 CXCL12 FAS CXCL13 CXCL5 CCR5 CXCL1 MMP9 TNF CCL2 MAPK14 CXCL11 IRAK3 TNIP3 CD8A PMC8764238__F1 Molecular Mechanism of Puerarin Against Diabetes and its Complications STAT3 FOXO1 CTNNB1 PMC7277336__F1 Signaling cascade of insulin-like growth factor 1 (IGF-1) and its potential impacts in metabolism, its interactions with transforming growth factor B3 (TGFB3) and the biological functions of the IGF1, IGFBP2 and TGFß3 genes BAD IGF1 FOXO3A GSK3B IGF1R MTOR IRS1 TGFBR1 PMC8430873__F3 Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC) CDC2 BAX BAD PMC9357648__F8 lncRNA XLOC013218 promotes cell proliferation and TMZ resistance by targeting the PIK3R2‐mediated PI3K/AKT pathway in glioma BAX SP1 PIK3R2 GSK3B MTOR PMC11922625__F2 Interaction of tau and DRN CSA2 CDK5 CDK3 PMC6122628__F2 HUWE1-mediated proliferation/differentiation MAX ATOH1 SHH MYC HUWE1 CTNNB1 PMC3312987__F2 Commonly mutated pathways in glioblastoma CDK6 NF1 PTEN CDK4 PMC4315039__F2 Functional components of the GDR pathway ATR ATM PMC9115588__F5 Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities STAT3 FYN GSK3B LRP5 LRP6 CCND1 CTNNB1 PMC3863542__F1 UPR signaling pathways in mammalian cells ATF4 EIF2A XBP1 PMC3812807__F7 PKCE ACTIVATION PROMOTES FGF-2 EXOCYTOSIS AND INDUCES ENDOTHELIAL CELL PROLIFERATION AND SPROUTING STAT3 FGFR1 KDR PMC4186798__F6 Novel Compound 1, 3-bis (3, 5-dichlorophenyl) urea Inhibits Lung Cancer Progression BAX BCL2 MTOR CCNB1 CDK4 PMC3183286__F2 The role of sphingosine kinase localization on substrate utilization and delivery of S1P to specific sites for secretion or loading of intracellular effectors HDAC1 TRADD HDAC2 TRAF2 PMC5166441__F1 Complement system CRP C6 CD59 FH C7 C5AR2 HEL-S-62p C2 C9 C4A C4B_2 PMC10987323__F10 MtETC in M2 macrophage polarization PFKFB1 GLS CD36 F2 MTOR PMC6076394__F7 Network obtained from genes sharing different pathways ACTN1 FCGR3B EGF CSF2RA LCP2 ID2 FZD2 PTPN11 NFATC1 APC2 TNF E2F5 CRK FYN SLIT2 RHOD PDPK1 GAB2 HEL-S-15 PMC3666507__F4 Cross-talk between muscle (pink) and tendon (dark grey) cells in Drosophila RYK CTNNB1 PMC7488355__F3 Association between Alcohol Use Disorder and manifestation of Alzheimer’s disease (AD) CDK5 GSK3B MTOR PMC4900635__F7 MACC-1 Promotes Endothelium-Dependent Angiogenesis in Gastric Cancer by Activating TWIST1/VEGF-A Signal Pathway MACC1 GC VEGFA TWIST1 PMC6714139__F2 LPS/TLR4 signalling pathway TBK1 TIRAP TLR4 CD14 IRF3 IRF7 IL6 TRAF3 MTOR TRAF6 MYD88 PMC8261291__F1 Targeting Bruton’s Tyrosine Kinase in CLL SYK CD79A BTK BCR PLCG2 BLNK CD19 LYN MTOR PMC8882816__F3 Innate Antiviral Immune Response by Porcine Enteric Coronavirus STAT3 TBK1 MAVS STAT2 IRF9 IRF1 IRF3 MYD88 TLR3 TLR4 TLR8 TLR7 TYK2 PMC6961549__F1 Crosstalk between hypoxia and the unfolded protein response (UPR) pathways SIAH2 HIF1A ATF4 MTOR XBP1 VHL PMC6531879__F4 Mapping of hits in the MAPK signaling pathway MAX ECSIT EGF JUN FAS RAF1 EGFR CD14 TRAF6 DAO FLNA NGF MOS NLK GRB2 BDNF TRAF2 PMC5715835__F3 Molecular interactions and outside versus inside cell identity CDX2 TEAD4 CTNNB1 GATA3 PMC4269892__F6 Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer SMG1 MARVELD1 PMC11779893__F6 Possible mechanism of AMLN diet and exercise on mitochondrial homeostasis during MASLD development LONP1 FGF21 CLPP ATF4 PMC8903056__F3 SIRT6 and epigenome maintenance CGAS WRN HP SIRT6 PMC10608708__F7 Mapping of the top targets in the PI3K-AKT signaling pathway SYK EIF4B BAD RBL2 PTEN CD19 MTOR MYC EIF4E RHEB TSC2 BCR RXRA GRB2 PMC4774216__F1 RhoA/Rho kinase in spinal cord injury LPA ROCK2 HEL-S-62p ROCK1 LINGO1 PTEN ARHA PMC8623046__F9 Protection against Oxidative Stress-Induced Apoptosis by Fermented Sea Tangle (Laminaria japonica Aresch) in Osteoblastic MC3T3-E1 Cells through Activation of Nrf2 Signaling Pathway BAX KEAP1 FST PMC9252758__F2 Flavonoids Targeting the mTOR Signaling Cascades in Cancer: A Potential Crosstalk in Anti-Breast Cancer Therapy RHEB TSC2 TSC1 RNF168 PMC4274867__F1 KEGG pathway of 470 DEGs downregulated in the frontal cortex of AD identified by RNA-Seq data analysis GRPR PRLR LEP OXTR SCTR TSHR TACR2 LEPR MC2R GCGR FSHR PRLHR LHCGR CALCR LTB4R LPA MLNR GHSR PRL GPR78 GHR GIPR PMC4691146__F2 Processes affecting TOB1 levels and diverse mechanisms underlying TOB1 tumor suppression activity BAX AURKA TOB1 APC GSK3B RPS6KA1 SMAD4 PTEN CCND1 CTNNB1 PMC4405319__F2 Toll-like receptor 4 (TLR4) signalling TBK1 CD1B TIRAP TLR4 MAL CD14 IRAK1 IRF3 TRAF6 LBP MYD88 PMC6454697__F5 The relationship between zinc finger proteins and hippo pathway in cancers MZF1 PMC7812690__F4 Cardiotoxic effects of angiogenesis inhibitors BAX BAD MTOR PMC10526871__F3 Nuclear Estrogen Receptors in Prostate Cancer: From Genes to Function EGF JUN IGF1 SRC PMC11491369__F3 Mitochondria in embryonic heart development PINK1 FIS1 OPA1 MFN1 MFN2 PMC6269824__F1 Biosynthetic pathway of sialic acids and feasible implementations of artificial precursors NANP GNE NANS PMC6555789__F9 Summary and integration of the main results ALOX12 SLC6A9 ALOX15B PMC7058019__F2 Development of a CRISPR/Cas9n-based tool for metabolic engineering of Pseudomonas putida for ferulic acid-to-polyhydroxyalkanoate bioconversion TES C1S HEL-S-5 FADD PMC6615111__F3 Molecular regulators and signalling mechanisms involved in the activation of astrocytes STAT3 CNTF GFAP LIF OLIG2 RGMA PMC4324900__F4 Identification of Genetic Determinants of the Sexual Dimorphism in CNS Autoimmunity THEMIS SYK AHI-1 PTPRK SHE PMC9027032__F9 Differential Nanoscale Topography Dedicates Osteocyte-Manipulated Osteogenesis via Regulation of the TGFB Signaling Pathway COL1A1 EP300 RUNX2 PMC7491975__F2 Different regulation of angiogenesis and vessel stability between VEGF and angiopoietin signaling, relating to regorafenib action ARHA SRC PMC6693777__F6 Transcriptome analysis of the molecular mechanism underlying immunity- and reproduction trade-off in Locusta migratoria infected by Micrococcus luteus STAT3 EGF KLF2 BNIP3 PTEN IL6 INS SKP2 FOXG1 INSR CDK2 ATM GOPC MDM2 PMC3394120__F4 Cytoskeleton remodeling signaling, an example of a differentially regulated pathway in the motor cortex of SALS VLDLR HEL-S-77 GSK3B NEFL PIN1 NEF3 CTNNB1 NEFH CDK5R1 DAB1 CDK5 FYN WASF1 DCTN1 PMC8002322__F2 Targeted therapies directed at cell cycle and DNA damage repair pathways ATR BRCA1 ATM SSB CCND1 PMC4926301__F8 Angiogenin ameliorates corneal opacity and neovascularization via regulating immune response in corneal fibroblasts TBK1 TLR4 IL18 IL4 MYD88 PMC3223722__F1 Glycogen synthase kinase 3 modulates the function of key signaling proteins in the wnt pathway APC MYC CTNNB1 PMC11855587__F1 Endogenous Specialized Proresolving Mediators in Mast Cells and Their Involvement in Inflammation and Resolution ELOVL2 FADS2 ELOVL5 FADS1 PMC5916807__F7 Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types RAD18 CDC20 APC PTEN TERT APC2 MYC SKP2 MDC1 HERC2 HEL-S-92n RBX1 BTRC BRCA1 RNF168 RNF8 CDC27 PMC7333221__F1 Origin of B-cell-associated malignant tumors and the anti-tumor mechanisms of HDAC6 inhibitors FOXO1 PDC CTNNB1 HDAC6 PMC7348171__F2 Functions of NgBR include regulating cholesterol trafficking via directly binding to NPC2, hepatic FFA and TG metabolism through inhibiting LXRA transcription in an AMPKA‐dependent pathway NPC2 TG RAF1 FASN GSK3B MDM2 VEGFA PMC7133748__F2 Nectin adhesion pathway (positive regulation of JNK cascade) was more active in the nonresponder tumors (upper panel) than in the responder tumors (lower panel) CDC42 FARP2 SRC PMC10151556__F1 An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review NLRP3 TXNIP FOXO1 IL1B PMC5314727__F4 Cell Cycle M-Phase Genes Are Highly Upregulated in Anaplastic Thyroid Carcinoma LTBP1 AURKA ASS1 KIF20A SHISA2 KIF23 PYGL ABHD2 EPB41L5 MME MRTO4 RALA CCBE1 INF2 OSMR GALNT12 SPC24 CDKN3 CENPN dik PLAUR SYNE4 GPRASP1 CLIC3 RALGPS1 PKP4 UBL3 CENPA PPL RGL3 HGF SHOX2 E2F7 CENPE NEDD9 GTSE1 SHCBP1 CTPS1 PLS1 UCK2 STIL HEL-S-134P CXADR CAV2 TRIP13 ANXA3 NUF2 PCP4 MAL RRM2 HEL-S-34 MKI67 SEC63 ZMYND11 BCAT1 PMC3890716__F2 Schematic for the putative biosynthetic pathways of three major classes of active compounds in I IPP CAD AMT DDC CCR1 STS PMC11868730__F3 Drug-active components-common targets-pathways network diagram PPARG CHRM3 PPP3CA MYC NCOA7 ALB HMOX1 CHRM4 DRD1 ADRA1B ALOX5 F10 FGFR4 PTGS1 MMP2 CASP9 NOS2 GSTM2 CASP8 SLPI MMP10 MAP4 SLC2A2 TNF SCN5A PAQR6 GABRA3 CYP2B6 GABRA2 CHRM2 ADRB2 MAP3K7 HAS2 BCL2 MUC4 HEL-S-22 VEGFC TGFB1 CHRM1 ADRA1A F7 PTEN HTR2A CTNNB1 KCNC2 NCAM1 CHRNA2 SLC6A3 F2R INSR F3 PDE3A DPP4 AHR TOP2A HSP90AB1 CDC2 CYP1A2 ACHE ICAM2 BAX PSMD11 JUN SELE PON2 CYP1B1 OPRM1 PTGS2 CYP1A1 SLC6A2 PTPN22 DIO1 IKBKB RELA CASP3 STAT4 XDH PRSS1 AHSA1 CYP3A4 GJA1 PMC5431130__F4 Representative schematic of the proposed TRIF contribution to NFKB-dependent TNFA promoter activation TLR4 MAL CD14 TRAF6 LBP MYD88 PMC8883581__F6 Overexpression of MUC1 Induces Non-Canonical TGFB Signaling in Pancreatic Ductal Adenocarcinoma SMAD2 MUC1 SMAD4 PMC6883365__F2 Network visualization of pathways enriched with genes influencing non-platinum-based treatment response in oral cancer.Hexagon shapes are genes PPIC RAF1 GNAT2 GSK3B HDAC3 KLHL12 PSMD3 CTBP2 FYN CCNE1 PLCG2 SRY SOX1 SOX7 NRF1 UBB TBCC KIFC3 SOX13 APC MED10 USP11 TBCD LRP6 RGS11 PSMD7 FZD4 LONP2 CALM1 WNT3 GNG7 FZD5 VBP1 TERT NR1C2 RYK ASH2L ARNT2 AHR FZD1 ARL2 PSMB8 KRAS ACOT12 NFYB PYGO1 CCNE2 PSMD9 MEN1 IKBKB NFKBIA CREBBP EP300 ACADL LYN CPT1A LEF1 PS1TP5BP1 GNGT1 PPARG SYK PSME4 NFATC2 CARD11 GNG12 TMED5 GNAZ SIN3B PORCN DKK1 PDPK1 WNT4 SRC NPAS2 TBCB MED23 MED17 FBXW9 FZD2 GNB2 HEL-S-278 TLE4 RSPO3 TUBB SNX3 HRAS VPS29 VPS35 PAK1 NFYC PFDN2 TCP1 TAB3 MED19 PSMB2 PSMD2 RORA IKBKG TRRAP TLE2 HELZ2 CCNO HADHB TEAD2 DKK2 LEO1 DCAF7 KMT2C UBC GNG10 GNG13 GNG4 PYGO2 SOX2 GNG3 RSPO1 GNG2 NR1C1 RNF43 MED22 TNKS MTF1 GNB4 SOX3 DVL3 GNG11 WIF1 PMC6883365__F1 Network visualization of pathways enriched with genes influencing platinum-based treatment response in oral cancer.Hexagon shapes are genes DVL1 RAF1 GSK3B HDAC3 KLHL12 PSMD3 RGS7 SOST CTBP2 MED29 FYN PLCG2 SRY SOX1 SOX4 UBB TBCC SOX13 SIN3A SP1 TUBA3E APC LRP5 TBCD RGS11 PSMD7 TBCA HEL-S-71 FZD4 LONP2 SMURF2 FBXW4 GNG7 DKK4 CCT4 TERT NR1C2 RYK NCOA6 GNGT2 ASH2L GNB1 ARNT2 MED16 AHR RGS1 FZD1 PSMD6 GNAI1 PSMD10 GNAT1 HEL-S-91n ARL2 TBL1X AHRR KRAS NFYB SFRP1 PYGO1 MED31 TBCE MAP3K7IP1 IKBKB NFKBIA NFYA CREBBP LYN CPT1A LEF1 PS1TP5BP1 SYK NFATC2 GNG12 MED13L GNAZ SOX6 MED12 FZD8 MED8 PORCN DKK1 SRC RSPO4 NPAS2 TBCB MED23 MED17 CCS RNF146 FZD2 GNB2 RSPO3 TUBB MED21 SNX3 WLS MED11 HRAS CCT7 RGS6 PAK1 ZNRF3 NFYC PFDN2 TCP1 TAB3 MED19 PSMB2 HEL-S-100n PSMD2 RORA PSMD1 TRRAP TLE2 CDK19 HELZ2 BTRC TEAD2 CHUK LEO1 MED13 MED28 UBC GNB3 GNG10 GNG13 GNG4 GNB5 SOX2 GNG3 CCNC ESRRA GNG2 NR1C1 MED9 MED22 TNKS CBY1 TRFP FRAT2 MTF1 GNB4 RELA SOX3 SKP1 DVL3 KIF13A GNG11 YWHAZ WIF1 PMC6567518__F8 Summary of the function of OD-Exo in the odontogenic differentiation of DPSCs through TGFB1/smads signaling pathway via the transfer of mircoRNAs LTBP1 TGFB1 SMAD2 SMAD4 PMC9066101__F3 Smad3 Signatures in Renal Inflammation and Fibrosis CRP SMAD2 SMAD4 CDK2 CDK4 PMC9066101__F2 Smad3 Signatures in Renal Inflammation and Fibrosis CRP SMAD2 SMAD4 FOXP3 PMC9066101__F1 Smad3 Signatures in Renal Inflammation and Fibrosis CRP SMAD2 SMAD4 CDK9 SIRT1 CTNNB1 PMC316396__F7 Axial and appendicular cartilage SHH GATA4 PAX1 PMC6318995__F7 Characterization of complex transporter-mediated model of carbon allocation and energy supply for oil synthesis in developing P LPA MAL PC ABCB9 PMC7017275__F2 Identified downstream targets of YB-1 in gynecological cancer EGFR CXCR4 PMC7017275__F1 Simplistic model of the mTOR signaling pathway in cervical cancer SGK1 EGFR EIF4H MYC DEPTOR EIF4E PMC9361070__F2 Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer HMOX1 STEAP3 KEAP1 HEL-S-102 PMC8829599__F5 Renal calcium and magnesium handling in Gitelman syndrome TRPM7 UMOD TRPM6 CNNM2 PMC9361070__F1 Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer GLUD1 SLC3A2 LOX GPX4 LPCAT3 FACL4 PMC8831326__F7 Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart GDF8 SMAD2 SMAD4 PMC9553959__F2 Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways RFWD2 CASP9 ATR CD2 AIFM2 PERP PTEN MTOR MYC CDK6 IGF1 CASP3 MDM2 CDK4 PMC8804886__F5 mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion SMAD1 DKFZp781O1323 ID2 BMPR1A APC GSK3B SMAD6 SOX2 PTEN MTOR ID1 ID3 RHEB RICTOR TSC1 BMP2 PMC9553959__F4 Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways IFNG HEL-S-99n TAPBP CANX CTSL CTSS TNF PMC9553959__F3 Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways RHEB TSC2 GAL BAD BCR CD37 BRCA1 RBL2 CD19 PTEN RAC1 IRS1 PMC10377929__F7 Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3B in Cultured Human Dermal Papilla Cells APC LRP5 LRP6 CTNNB1 PMC5270332__F8 Schematic diagram depicting the KRT19-mediated regulation of NUMB expression, NOTCH signaling pathway and cancer/cancer stem-like cells (CSLC) properties in KRT19-overexpressing breast cancer cells HRAS MAML1 NUMB CCND1 HES1 RAC1 KRT19 NOTCH1 CTNNB1 PMC3427211__F3 Microbes-induced EMT at the crossroad of inflammation and cancer TBK1 TIRAP TLR9 AIM2 TLR5 IRF3 TRAF6 MYD88 TLR1 TLR3 IL16 TLR4 NOD2 TLR8 NOD1 TLR7 PMC6454697__F4 miRNAs and Hippo pathway LATS1 LATS2 DGCR8 DROSHA PMC9554999__F3 Comparison of meiotic transcriptomes of three maize inbreds with different origins reveals differences in cell cycle and recombination SVIP BAX SEC63 CASP12 SEL1L ELF2 ATF4 ATP6 WFS1 SEC62 PMC6916696__F1 The diverse regulatory mechanisms of circRNAs in GC CDH2 PTEN MTOR PMC8197527__F6 Carcinogenesis of Triple-Negative Breast Cancer and Sex Steroid Hormones PMC7993665__F7 Signaling pathway diagram GSDMD NLRP3 TXNIP IL1B PMC11844283__F7 Schematic model illustrating the mechanisms by which DSF/Cu activates innate immune signaling pathway to enhance anti-tumor immunity and potentiate therapeutic responses to PD-1 checkpoint blockade (created with BioRender IFNG TBK1 CGAS IRF3 CCL5 CXCL10 PMC9322395__F1 Consideration of possible effects of vitamin D on established cancer, with reference to malignant melanoma NR1i1 CYP2R1 DHCR7 PMC7203474__F2 Iron recycled and released by TAMs sustains the cancer progression TF SCARA5 LCN2 CP PMC5352101__F3 Type I insulin-like growth factor receptor signaling in hematological malignancies TSC2 BAD TSC1 FOXO1 GSK3B PTEN GRB2 IRS1 PMC7203474__F3 Copper addiction of cancer cells could prevent the pro-inflammatory phenotype of macrophages LOX CCND1 PMC3560469__F2 Angiotensins in the RAS DAP ACE2 PMC9372561__F1 Gut microbiota dysbiosis: The potential mechanisms by which alcohol disrupts gut and brain functions TLR4 APC IL1B PMC4897699__F7 Macrophage Migration Inhibitor Factor Upregulates MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury CD44 CD74 MIF PMC4430931__F1 Signaling pathway of the extrinsic factors, glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) ETV5 LHX1 GDNF FOXO1 ID4 BCL6B RET NANOS2 FGF2 PMC8340306__F1 CGAS-STING signalling in liver diseases TBK1 STAT1 CGAS STAT2 IFNAR1 IRF3 JAK1 TYK2 PMC8626953__F1 To explore immune synergistic function of Quercetin in inhibiting breast cancer cells STAT1 WAS PMC4417456__F4 Signaling pathways deregulated in HPV-associated HNSCC CASP8 LTBR EPHA2 EGFR PTEN B2M DDR2 TRAF3 MYC FGFR2 RB1 CDKN2A TP63 ERBB2 FGFR3 HLA-B BIRC2 HLA-A CCND1 FADD PMC8699920__F1 Emerging Molecular Dependencies of Mutant EGFR-Driven Non-Small Cell Lung Cancer STAT3 EGFR GRB2 PMC9181319__F1 Roles of RANK/RANKL/OPG in Cardiac, Skeletal, and Smooth Muscles in Health and Disease TRAF5 NFATC1 TRAF6 RUNX2 TRAF2 PMC11855193__F2 ApoA-I regulates blood sugar PDX1 EBP IRS1 PMC7397746__F1 Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids LPA PSD CEPT1 PMC3584916__F3 Signaling pathway of IFIT family genes TLR3 TLR4 TLR9 IRF3 IRF7 MYD88 PMC6520733__F6 Proposed model for ANXA2 regulation of AKT activation EGF HEL-S-2a EGFR ANXA2 PTEN PMC9359989__F6 Ingenuity pathway analysis of synaptosomal miRNAs in AD ENDOV RELA PMC7481617__F1 Estrogen receptor (ER) and pan-HER signaling inhibition has synergistic activity and leads to gene expression changes associated with good prognosis in non-small cell lung cancer (NSCLC) MIA EGF GRB7 JUN CXXC5 PGR EGFR FOXC1 AREG FOS PMC3584916__F4 Antiviral and immune regulated function of IFIT family genes IFIT5 BAX TBK1 MAVS IFIT1 IFIT3 IFIT2 IRF3 ELF3 PMC7658690__F7 Relationship between target and pathway network JUN EGFR RELA GSK3B PTGS2 MMP9 TNF FOS IKBKG PMC9303342__F2 Co‐option of stress mechanisms in the origin of evolutionary novelties PTGER2 PGR PTGER4 PMC8984190__F2 Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer CDC42 GOLPH3 PKD1 GPRC5A SRC PMC8984190__F1 Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer LTK GPRC5A PLCB3 SRC PMC9589207__F2 Non-cardiomyocytes in anticancer drug-induced cardiotoxicity: A systematic review NRG1 ERBB4 ERBB2 MTOR PMC2756316__F5 Proposed model for the interaction between PyVmT and IR or IGF-IR PLCG1 GRB2 SRC PMC9661723__F2 Features and factors that dictate if terminating ribosomes cause or counteract nonsense-mediated mRNA decay UPF2 SGA56M SMG1 SMG9 SMG8 SMG6 SMG5 DHX34 PMC6286812__F2 NOD-like receptor signaling pathway from KEGG shown with drugs, targets and known mechanism of action (→ denotes activation, ---> and ---> denote indirect effect and — denotes binding/association) CASP8 TAB3 CARD6 TRAF6 CCL2 PSTPIP1 TRIP6 ERBIN MAP3K7IP1 CASP5 NOD2 NOD1 CARD9 IL1B PMC8776082__F1 Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases IL20RB S100A7 IL24 MUC1 FLG SOCS3 JAK1 TYK2 IL22RA1 PMC5854489__F3 Glaucoma as a metabolic optic neuropathy: making the case for nicotinamide treatment in glaucoma NMNAT1 NAMPT NMNAT2 NADSYN1 NMNAT3 PMC6042731__F3 Cell cycle in LNCaP cells after NETD DBF4 PCNA CDC6 ORC6 SMAD2 SMAD4 MYT1 PLK1 SKP2 RAD21 CDK7 CDC45 CDK2 MDM2 PMC5217522__F2 Possible explanation for opposing Notch-1 effects on NSCLC cells.Notes: Overexpression of constitutively active proteins is susceptible to experimental artifacts, the extent of which can be greatly modulated by environmental conditions IGF1 IGF1R IGF2 PMC8320333__F8 A New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma CDK6 MTOR CDK4 PMC11311579__F1 Metabolic pathway of vitamin D and the role of VDR (Vitamin D Receptor) in signaling based on Płomiński et al NR1i1 CYP2R1 CYP11A1 DHCR7 CYP27A1 PMC6413278__F7 The proposed mechanisms for the inhibitory effects of MS-275 on osteogenesis in VICs ROR2 GSK3B LRP5 LRP6 ARHA CTNNB1 PMC4218909__F2 Cartoons of PAR1 activation by thrombin in the membrane lipid-rafts of endothelial cells when EPCR is free or occupied by its natural ligand PC ARHA RAC1 PMC7308527__F1 Tryptophan (Trp)→ kynurenine (Kyn) metabolic pathway HEL-S-90n KYNU KMO PMC6657359__F7 Model for Hand2-Dependent Mechanisms That Regulate iPM Formation by GHMT HCN4 ISL1 TBX18 SHOX2 TBX3 NKX2-5 HAND2 PMC4218909__F1 Cartoons of protein C activation and APC signaling in the membrane lipid-rafts of endothelial cells APC PC RAC1 PMC5217522__F1 Simplified schematic of Notch signaling.Notes: In mammalian cells, Notch receptors are synthesized in the endoplasmic reticulum (ER) IGF1R MTOR MYC FURIN CTNNB1 PMC7254680__F1 Scheme for the overall GPI-APs biosynthetic pathway, structural remodeling and transport PIGC GPAA1 PIGH DPM2 PGAP1 PIGO PGAP2 PGAP3 PIGF PIGW PIGL HEL-S-5 PGAP6 PIGK PIGM PMC3225910__F1 Signaling network connecting Rheb and AMPK RHEB TSC1 PTEN PMC4811470__F2 Integration of tissue metabolomics, transcriptomics and immunohistochemistry reveals ERG- and gleason score-specific metabolomic alterations in prostate cancer SGMS1 SCD FASN PMC4157363__F1 Determinants of Breast Cancer Progression HOXD10 HEL-S-62p C2 LIF PTEN PMC3641099__F1 Gene Expression Analysis of Peripheral Blood Cells Reveals Toll-Like Receptor Pathway Deregulation in Colorectal Cancer MAPK11 CPD PMC5384880__F5 Differential expression of proteins in the nucleus accumbens generates specific network interactomes in ENT1−/− mice VDAC3 THY1 FLOT2 SQSTM1 TRAF6 OTOF HEL-S-42 KCNK2 FYN PCSK1 SLC29A1 EIF2A NRGN PENK PCSK2 PAG1 PDYN SLC18A3 CDC34 OSBP2 DNPH1 BCLAF1 PCSK1N ChAT SLC1A2 GJA1 PMC5384880__F4 Differential expression of proteins in the dorsal hippocampus generates specific network interactomes in ENT1−/− mice NCAM2 WIPF3 GRIA2 HPCAL1 ARPC2 CACNG8 ARPC5 INA PPP3R1 SLC32A1 PPP3CA NEFL COXFA4 MBP SLC6A11 NDUFB4 VAMP1 GAD2 AKAP7 GAS7 PYGM BASP1 L1CAM NEF3 NEFH MPP2 VAPB ARL15 WASF1 S100B PMC5406854__F2 Ways of targeting MYC and its transcriptional output using specific signaling pathway, BET bromodomain, and complex inhibitors in MYC-dependent malignancies MAX AURKA BRD4 FBXW7 GSK3B POLI MYC TEF PMC12250682__F7 Multifaceted antitumour mechanisms of Astragalus polysaccharides (APS) in liver cancer CDH2 BAX CCND1 PMC7924210__F2 Simplified mechanism of the classical endocannabinoid ligand signaling pathway NAPEPLD PTPN22 FAAH PMC6718562__F6 Role of IL-1 cytokine family members in the immunological history of the hepatocarcinoma IFNG CDA NLRP3 IL33 AREG PMC7814617__F7 Schematic model for the mechanism of action of anemoside B4 in the treatment of colitis BAX TLR4 S100A9 PMC8182917__F1 Estrogen/ER in anti-tumor immunity regulation to tumor cell and tumor microenvironment FOXA1 ERG CTNNB1 GATA3 PMC5666320__F6 Model of Rho/F-actin pathway repression by EWS-FLI1 via MRTFB/YAP-1/TEAD transcriptional perturbation TPM1 CALD1 MRTFB DKFZp686P11128 PMC5582828__F2 Mechanisms by which fusion genes promote kinase activation and cell survival and opportunities for therapeutic intervention BAX BCR CRLF2 PMC7772217__F3 Role of the inflammasome complex in modulating immune responses in a Toxoplasma gondii infection NLRP1 SYK CASP8 NLRP3 GBP1 CARD9 PMC4503882__F4 Postulated signaling pathway for MMF through binding to HCAR2 HCAR2 CAMKK2 NAMPT SIRT1 IL1B PMC11675326__F19 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation FH NOD2 MCU APP FADD PMC11675326__F18 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation SYK EIF4B BAD RBL2 PTEN CD19 MTOR RAC1 IRS1 EIF4E RHEB TSC2 TSC1 BCR CD37 MDM2 GRB2 PMC5411695__F3 Hedgehog (Hh) signal transduction in the primary cilium EVC GPR161 SUFU PTCH1 SHH SMO GLI3 PMC11675326__F17 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation MAX RAN JUND FAS TRADD CD14 CYC1 TNF TRAF6 FLNA MEF2C MYD88 NLK GRB2 TRAF2 PMC3236573__F3 Ovarian cancer ascites-mediated protection from TRAIL-induced apoptosis BAX FADD PMC6212884__F1 Canonical TGFB/SMAD signaling pathway SMAD2 SMAD4 TGFBR1 PMC9035937__F4 Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease VCAM1 VEGFA PMC11742290__F2 LGR5 in the WNT/Beta-catenin pathway RNF43 APC LRP5 ZNRF3 LRP6 MYC GPR49 CCND1 CTNNB1 PMC11647666__F7 Proteome analysis after Mg treatment for t = 2 days ATP5F1D GABARAP RAB7B IDH3B NDUFS5 SDC4 BNIP3 HIF1A SMPD1 MARS2 ATP5PO SUCLA2 PTS COL4A1 B4GALT5 CPT2 HEL-S-26 PYGM NMNAT1 ATP1B1 IMPDH1 AKR1C1 PIGV NANS GANC HEXA PLCB1 GCLC COL16A1 AMBRA1 APIP COL5A2 SDSL C9orf72 HEL107 TNC NAPRT HSPG2 BTD PPP1CC AGPAT3 DHFR SGMS2 COL3A1 COX7A2L PNP COL1A1 STT3A PGM2L1 CITED2 COL1A2 CA13 UROD CYB ALDH5A1 ITGA1 NDUFA2 NDUFA5 PMC5754510__F1 Important growth factors and cellular signalling pathways involved in tumourigenesis and angiogenesis of NETs CDC2 BAD PTEN IRS1 CTNNB1 EIF4E TSC2 CDK6 CDK2 ATM SMO CDK3 MDM2 GAS1 PMC3760066__F2 Two TLR signaling pathways TBK1 MAL CD14 IRAK1 IRF3 IRF7 TRAF6 IRAK4 MYD88 PMC10452677__F1 Relevance network of genes, transcription factors, small molecules, functional classes, miRNA, and biological processes that are shared between DMD and HMB (based on Pathway Studio Web Mammalian) BAX IL10 GDF8 TGFB1 LEP MYF6 IL6 TNF CSF3 TRIM63 IFNG IGF1 FOXO1 SIRT1 PMC3393470__F1 Chemical structures of PSI-352938 and its potential metabolites and the proposed metabolic pathway of PSI-352938 activation GUK1 CYP3A4 ADA PMC11675326__F21 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation CDC42 BAX CRK BAD FRS2 RHOD GSKIP GRB2 SHE BDNF TRAF6 RAC1 PMC3587990__F4 Interaction of marine compounds on survival and apoptotic signaling molecules BAX BAD MTOR PMC3587990__F3 Pathway of apoptosis BAX BAD BCL2 PMC3348077__F7 Signaling pathway for the cytoprotective effect of STI571 in TRAIL-treated colon cancer cells TRADD TRAF2 FADD PMC3587990__F2 Scheme of survival signaling cascade by receptor tyrosine kinases via PI3K/AKT mediated survival BAD PTEN MDM2 PDK2 MTOR PMC11675326__F20 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation RHEB ATR HEL-S-69p ATM MCU PTEN MB PMC6542064__F7 Temporal dependence of G2/M DNA replication checkpoint mechanism on the G1/S transition mechanism CDC2 DBF4 TFDP1 CDC6 ORC1L SKP2 CCNH RB1 PKMYT1 CCNE1 CDKN1A CDC45 CDKN1B WEE1 MCM3 CDK2 PMC3587990__F1 Scheme of PI3K/AKT mediated antiapoptotic regulations at the mitochondria BAX BAD MTOR PMC5384880__F8 Physiological development-functions associated with the dorsal hippocampus and nucleus accumbens of ENT1−/− mice MLYCD GPR37L1 SLC32A1 MARCKS SLC6A9 CSTB CERS6 MAOA HDAC3 NRXN2 DNAJC3 FYN MAPK8IP1 GAD2 SLC25A25 DTNBP1 RGS14 SLC17A6 PDE10A L1CAM ATP1B2 SLC10A4 CLCN6 ADAM10 ChAT WASF1 SDC3 VDAC3 GRIA2 THY1 PPP3R1 SLC7A11 NEFL MLSN2 ABCA1 SHANK3 ABAT KCNJ3 SLC6A3 SLC18A2 SLC29A1 ADAM22 CACNA2D3 NRXN1 NRGN ACHE CPLX2 SLC18A3 CD47 DBI SMARCD3 PTPRE SNAP25 RPS6KA3 KIF13A SLC1A2 GJA1 PMC5748601__F1 TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis TIRAP TLR4 IRAK1 IRF3 IRAK2 TRAF3 TRAF6 LBP IRAK4 MYD88 PMC2861144__F1 Novel targets for the treatment of autosomal dominant polycystic kidney disease RHEB EGF TSC2 JUN TSC1 IGF1 CFTR MTOR SRC MYC PMC2861144__F2 Novel targets for the treatment of autosomal dominant polycystic kidney disease RHEB TSC2 TSC1 IGF1 MTOR IRS1 PMC4951239__F2 Functional role of autophagy in gastric cancer MTOR SIRT1 PMC266780__F7 Scheme to illustrate the separate functions and regulation of conventional nonsarcomeric myosin IIA and myosin IIB LPA NGF RHO CP PMC9179868__F1 Crosstalk of Epigenetic and Metabolic Signaling Underpinning Glioblastoma Pathogenesis DERL3 EAF2 HK3 KEAP1 HEL-S-133P HK2 HEL-S-162eP EGFR HEL-S-30 PMC4429169__F1 Network uncovered using IPA PRKCI STAC DDIT4 JUNB CLEC4A MARCKS NTRK2 SBSN HBB UGT8 PMC4038542__F1 Complement activation and effector functions C6 C7 C9 C4B_2 PMC7423983__F3 Function of SIK1 in tumorigenesis HDAC3 SIK1 TCF4 HEL-S-11 IL6 ZEB2 ID1 LEF1 TWIST1 CTNNB1 PMC7423983__F2 Roles of SIKs in the regulation of glucose, lipid metabolism and inflammation are illustrated IL10 FAS TLR4 TRAF6 PCK1 IRS1 PMC7097452__F2 Prognostic and predictive enrichment in sepsis TREM1 NINJ1 TGFBI TGFB1 HTR4 DDIT4 CKS2 CD300C CXCL8 CD24 CX3CR1 IL36RN RGS1 LAT2 CCRL2 DCSTAMP HRG G0S2 PRIM1 TNF MAFF EMR3 RGS13 FFAR2 CEACAM8 PMC5453186__F3 Clostridium difficile infection IL1R1 NLRP3 TLR4 TLR5 NOD1 IL1B MYD88 PMC6537480__F2 Signaling pathway mediating cardiovascular protection of OT CAD MOS MFN2 PMC10939994__F2 Correlation of HDAC7 and three signaling pathways STAT3 BAD APC PTEN HDAC7 MDM2 PMC7179196__F1 PPARA and PPARG signal cascade following their activation by endogenous or synthetic ligands PBR BDNF TNF PMC11886387__F3 McCullough protocol: Base spike detoxification TLR4 PLG ACE2 PMC8908152__F6 Expression profiles of tRNA-derived fragments and their potential roles in lung adenocarcinoma MAX FAS TRADD CYC1 TNF DAO PMC6103720__F4 Autophagy contributes to integrin recycling and degradation TBC1D14 ULK1 SRC RAB25 UBB PMC8892718__F3 Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions TSLP CCL26 IL33 AHR PMC3154366__F4 c-Myc regulates the rate limiting steps at the entry into glycolysis ALDOB FBP2 HK3 PGM3 PFKP HK2 FBP1 PFKL GCK HEL-S-87p PFKM PMC9028333__F1 Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory Activities BAD SOX2 ATF4 MTOR TRIB3 ID1 PMC7791970__F7 Schema of the signaling pathway involved in HSP60-mediated NLRP3 inflammasome activation and subsequent IL-1B production NLRP3 IL16 TLR4 MYD88 PMC12048151__F1 How two mutations associated with developmental defects impact BMP4 secretion FAM20C BMP4 BMP7 PMC6757435__F9 Signaling pathway proposed in this study TIAM1 RAC1 PMC8038777__F2 Granulocytes role in CRC CCL11 CCL3 CCL15 CXCL1 EPO ARG1 TNF IFNG CCL24 IL25 CCL4 S100A9 IL1B PMC9669439__F2 Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma ACLY GLUD1 RAB11B GLS HEL-S-133P IDO1 HK2 FASN BCAT2 ARF6 BCAT1 KRAS PMC4980741__F2 Signaling pathways regulated by SHP-2 in the gastrointestinal tract STAT3 EGF HGF IRS1 CTNNB1 PMC8744322__F7 Modification of mesenchymal stem cells by HMGB1 promotes the activity of Cav3.2 T-type calcium channel via PKA/Beta-catenin/Gamma-cystathionase pathway HMGB1 GSK3B CTH CTNNB1 PMC6580874__F3 Simplified schematic of the PI3K pathway, which highlights the common targets for small molecule inhibitors RICTOR BRCA2 PTEN MDM2 MTOR IRS1 PMC7507442__F1 DNA damage and the programmed cell death pathway (apoptosis) induced by radiotherapy BAX ATR RAD1 MRE11A BCL2 ATM MDM2 SSB FADD PMC3215281__F7 Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease ERCC1 OGG1 XPA FEN1 PCNA PMC9371512__F6 The Bushen Huoxue formula in the treatment of osteoarthritis based on network pharmacology-molecular targets PPARG HPSE MMP12 HEL111 CYCS BRAF MYC CCL2 CXCL8 MPO THBD CHUK MMP2 MMP3 KDR SRC NR1i1 IL10 JUN SELE CTSL PTGS2 MMP9 TNF CXCL10 FOS CD44 NR1C1 HEL-S-130P RELA ADRB2 CASP3 ERBB2 BCL2 RET PMC2195911__F10 A molecular mechanism whereby cAMP inhibits T cell function CSK LCK PMC3485057__F4 Increased Biomass Yield of Lactococcus lactis by Reduced Overconsumption of Amino Acids and Increased Catalytic Activities of Enzymes AIP PMC3765067__F2 Map of molecular interactions involving GADD45 proteins and cell signaling pathways generated using Ingenuity Pathway Analysis software (IPA) NGF RAD51 PCNA BRCA1 TNFRSF1A ATF2 GRB2 MYC PMC4036354__F1 Cross-talk between Two Signaling Pathways Drives Aggressive Late-stage Breast Cancer♦ SMAD2 SMAD4 NEGR1 PMC11575037__F16 Selected subnetwork of the differential network for Artery Tibial tissue in Atherosclerosis LPL MOK LEP HGF FABP5 FABP4 MIF TNFRSF11B PMC11575037__F14 Figure shows selected subnetwork of the differential network for Artery Coronary tissue in Atherosclerosis LPL PPARG MOK NR1C1 FABP5 DPP4 MPO PMC8600921__F1 Cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies CD40 HMGB1 GSDMD NLRP3 TLR4 GZMA GSDMB AIM2 IL1B MYD88 PMC6204373__F2 TRAFs in canonical and non-canonical NFKB signaling pathways RELB TRAF5 TRAF1 TRAF3 TRAF6 TRAF2 PMC9357337__F4 ELIMINATOR: essentiality analysis using multisystem networks and integer programming WNT3A FZD7 FZD1 PMC6204373__F1 Role of TRAFs in TCR-, costimulatory receptor-, and cytokine receptor-associated signaling pathways controlling TFH differentiation STAT3 TBK1 IL21R IL7R TRAF3 TRAF6 ICOS STAT1 TRAF5 CXCR5 TRAF1 TRAF2 BCL6 PMC9357337__F3 ELIMINATOR: essentiality analysis using multisystem networks and integer programming WNT3A FZD7 FZD1 PMC4539521__F6 Changes in gene expression and MAPK signaling pathways in Cgasg1Δ and Cghal9Δ strains CDC42 FUS SLN PMC9514850__F9 Differential metabolic pathway and reaction analysis PAGE2 HTT PMC8702253__F8 Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking STAT3 EGF VEGFC IL10 TGFA RAF1 SOS1 EGFR PTPN11 IL4 IL10RA VEGFA IL6 KRAS IRS1 HRAS VEGFB EREG SOST KDR GRB2 PMC5654621__F1 Endosomal traffic jams represent a pathogenic hub and therapeutic target in Alzheimer’s disease SORL1 BACE1 BIN1 APP PICALM PMC6173469__F1 Genomic mechanisms of immune evasion in colorectal cancer: from discovery to clinical practice APC B2M CTNNB1 PMC6030495__F6 EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival STAT3 EGF EGFR SRC PMC7985675__F2 Retortamonads from vertebrate hosts share features of anaerobic metabolism and pre-adaptations to parasitism with diplomonads TF MRO AIP FES PMC3346698__F8 One of the KEGG prostate cancer pathways (b) the paths detected by our method PXN EGFR IRF2 SP3 BCL2 CDC37 PMC4958958__F1 PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy PACSIN2 MTHFD1 HEL-S-182mP DHFR MTRR TYMS MTR TPMT PMC3346698__F5 The main chain path of pheromone response pathway (b) the assembly paths detected by Scott et al CDC42 HEL60 FAR1 PMC4944657__F6 Antagonizing integrin beta3 increases immune suppression in cancer SYK STAT1 TLR4 PMC3318612__F8 Summary model of rAdV-sensing cascades in RAW 264.7 cell line TLR9 DDX41 AIM2 POLI IRF3 IRF7 MYD88 PMC3292304__F4 Gene functional association networks for selected pathways in p53 dataset BAD FAS MPHOSPH9 MCL1 IL3 CYCS SFN MPHOSPH6 BCL2L1 BTG1 HSPB2-C11orf52 YWHAQ SRPK1 APAF1 NCBP2 BAX CASP9 MPHOSPH10 BAG1 TNFSF6 MAPKAPK2 TNF SPN IGF1 BTG2 CASP3 HEL-S-102 BCL2 BCL6 PS1TP5BP1 BIK PMC5187845__F2 Acceleration of osteoblast differentiation through the p53–Akt–FoxO pathway PTEN GADD45A EIF4E PMC4432802__F1 Schematic representation of the principal pathways involved in glucose catabolism summarizing recent findings discussed in the Mini Review (red boxes) IFNG HEL-S-162eP PMC5685326__F1 PD-1 in T-cell activation, exhaustion, and effector function CD80 APC PMC5892988__F1 BMP receptor signaling pathway SMAD1 DKFZp781O1323 SMAD6 SMAD4 PMC3606422__F1 Methotrexate mode of action RFC1 ABCC1 DHFR ABCC3 GGH TYMS ABCG2 ABCC2 FPGS ABCB1 ADA PMC6953796__F4 Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34 PDC PC CIT PMC5892988__F3 Roles of the BMP system in steroidogenesis and mitogenesis in growing follicles BMP15 BMP6 STAR BMP2 BMP7 FSHR PMC6087588__F2 Proposed signaling mechanisms of adiponectin in prevention of ischemic stroke NR1C1 ADIPOR1 ADIPOR2 VCAM1 PMC5971020__F1 RIG-I-like receptor signaling pathway TRADD PELO DERA TANK IL2 TNF CYLD FADD PMC4939324__F3 Anti-inflammatory mechanisms of MFG-E8 in a LPS-TLR4 signaling pathway STAT3 TLR4 CD14 SOCS3 PMC8286283__F3 Cellular roles of ER-phagy and the contributions of metazoan ER-phagy receptors CCPG1 TEX264 ATL3 SEC62 PMC8249453__F4 Machine learning compensates fold-change method and highlights oxidative phosphorylation in the brain transcriptome of Alzheimer’s disease LPL NDUFB2 ATP5G1 CASP9 BAD NDUFA12 NDUFB9 CYCS NDUFV2 NDUFA6 CALML4 COXFA4 UQCRFS1 NDUFB1 ZNF183 MCU PMC4905711__F1 Role of Nrf2 and Autophagy in Acute Lung Injury RBX1 KEAP1 GCLM MAF PMC8536203__F10 Proteomic Landscape of Extracellular Vesicles for Diffuse Large B-Cell Lymphoma Subtyping CD79A RAF1 CD72 VAV2 CARD11 GSK3B CD22 PPP3CA IKBKG PRKCB BTK PLCG2 GC CHUK CD81 FCGR2B BLNK PIK3AP1 CD19 NFATC1 RAC1 FOS DAPP1 LILRB2 IKBKB LYN MAP2K1 GRB2 NFKBIB PMC3886588__F1 Targeting the Th17 pathway IL17RC IL16 IL21R IL23R IL1B PMC5811630__F7 Iron starvation responses LPA DCD PNP DUT PMC3921548__F1 Overview of arachidonic acid metabolism TES LTB LTA COX1 PMC2713571__F1 Proposed cuticle pigmentation and sclerotization metabolic pathway in T TH DDC CP PMC4682646__F1 Complement activation, regulation, and molecular basis for complement‐related diseases CRP CD59 LTA FH MAVS C2 VTN CD46 CD55 C4A C4B_2 PMC8511314__F9 Lysophosphatidic Acid–Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase LPA EGFR MTOR LPAR3 PMC7410257__F7 Kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media HRAS JUN EGFR JAK3 GRB2 MTOR TNF LAT2 FOS LCK PMC7322393__F1 Zoledronic acid (ZA) acts as immunostimulant and endosomal disruptor of dendritic cell in SARS-CoV-2 infection CD83 CD80 IPP CD1A PMC9317349__F1 Present Status, Challenges, and Prospects of Dihydromyricetin in the Battle against Cancer STAT3 BAX SP1 PTEN MDM2 MTOR NOX4 PMC4155175__F3 mGluR1-TRPC3 signaling at parallel fiber-Purkinje cell synapses RHO TRPC3 PMC8861314__F6 Asiatic Acid Attenuates Osteoporotic Bone Loss in Ovariectomized Mice Through Inhibiting NF-kappaB/MAPK/ Protein Kinase B Signaling Pathway DCSTAMP CTSK NFATC1 ACP5 PMC5880173__F1 Bone morphogenetic protein (BMP) pathway and potential strategies for therapeutic modulation SMAD1 DKFZp781O1323 SMAD4 PMC3825489__F3 Cross talk between the coagulation and complement system TF MASP2 HEL-S-62p C2 PLG PMC5622528__F9 Hexokinases link DJ-1 to the PINK1/parkin pathway HK2 GSK3B PTEN IGF1R IRS1 PMC5038858__F3 The Notch pathway in ovarian (A) clear cell carcinoma ES2 and (B) serous carcinoma OVCAR3 cells following exposure to vorinostat HEY2 HEL-S-11 CS NOTCH1 PMC10528301__F3 An Overview of CD133 as a Functional Unit of Prognosis and Treatment Resistance in Glioblastoma TSC2 TSC1 RAF1 EIF4EBP1 BCL2 SFN CDC37 MDM2 PTGS2 CCND1 EIF4E PMC9105159__F1 Wnt/Beta-catenin pathway modulation via DKK1 inhibition DKK1 APC GSK3B LRP5 LRP6 LEF1 CTNNB1 PMC5744151__F2 Restriction factors block multiple stages in the influenza virus life cycle MOV10 CCND3 RIN2 TRIM32 IFITM2 TRIM56 PKP2 B4GALNT2 RNASEL OAS3 RAC1 ISG20 TM9SF2 IFITM3 ZMPSTE24 ISG15 PMC11596795__F5 Metabolic pathway and relative abundance of key genes of DAMO bacteria (a–c) and DAMO archaea (d–f), with predicted metabolic function as recorded in KEGG HEL107 MTR PMC5733031__F1 Role of SOCS proteins in the regulation of the signaling pathways induced by recognition of gram-negative bacteria SOCS1 TLR4 MAL IRF3 SOCS3 MYD88 PMC10807637__F6 HDAC inhibitors target IRS4 to enhance anti-AR therapy in AR-positive triple-negative breast cancer IRS4 MTOR KRAS CCND1 PMC5733031__F2 Role of SOCS proteins in the regulation of the signaling pathways induced by recognition of gram positive bacteria SOCS1 TLR1 LTA MAL SOCS3 IRAK4 MYD88 PMC8019794__F3 Macroautophagy pathway and signaling ATG10 ATG3 ATG16L1 ATG12 ULK1 ATG14 MTOR ATG5 PMC6093783__F31 The biosynthetic pathway of polyoxin 292 POLL POLM POLK POLG POLI POLE PMC4339403__F3 Unfolded Protein Response in Retinal Vascular Diseases: Implications and Therapeutic Potential Beyond Protein Folding HEL-S-101 XBP1 PMC4132813__F8 Model depicting the role of the PP1A signaling pathway in coordinating the activation of BRD4 and P-TEFb for inducible gene expression BRD4 HEXIM1 CDK9 PMC9319031__F2 Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health SOX6 PCNA MTOR CCND1 H1-0 MGMT CDK4 PMC5340233__F4 SIN3A and SIN3B differentially regulate breast cancer metastasis TRADD CCND2 SOX21 PMC8124706__F1 Targeting BRAF and RAS in Colorectal Cancer JUN SOS1 EGFR GRB2 MYC PMC5889941__F1 Alterations in glucose and glutamine metabolism contribute to tumor growth and proliferation GLS HEL-S-133P PHGDH PMC6247426__F1 Metabolic reprogramming in HCC ACLY HEL-S-133P CD36 HK2 HEL-S-162eP FASN MAL LDHB CIT PMC3964053__F4 BMP signaling in germ cells across the Metazoa BMPR2 PGC SMAD1 DKFZp781O1323 PRDM14 SMAD4 GSC PMC4881575__F1 miRNA network regulating cancer metabolism FAS PTEN MTOR MYC PMC3506510__F2 Signaling pathways impinging on autophagy RHEB TSC2 RICTOR TSC1 PTEN MTOR PMC6400995__F1 Kynurenine pathway with a focus on KYNA synthesis KMO HAAO ND4 AHR ND3 PMC3739348__F6 Expression of some genes related to the cell cycle and apoptosis were significantly changed after LM23 knockdown, as shown by microarray analysis CDC2 FAS CDK6 CASP6 APC CDK2 MDM2 CDK4 PMC5549304__F6 H3K79 methylation pathway and potential therapeutic targets BRD4 WAC RNF20 PMC2694487__F5 Human presenilin 1 and 2 (PSEN1 and PSEN2) subnetworks PSENEN GPR37 PSEN2 YKT6 SNCA LFNG PMC5103945__F1 STRING analysis of metabolic and PI3K-Akt signalling pathways HEL-S-22 HEL113 FLNA EZR TUBA4A YWHAQ HEL-S-1 MDH2 HNRNPK AMBP FASN PCBP1 HEL-S-30 CLEC3B TUBB HEL-S-34 ACSL1 ACTN4 HEL-S-49 PLEC KRT31 CALM1 RPS12 PSAP HLA-A PMC4216117__F2 MicroRNA Network Dysregulated in Asthma Controls IL-6 Production in Bronchial Epithelial Cells MAPK14 NFKBID IKBKB SMAD2 IRF2 NFKBIE IL6 MTOR IKBIP CEBPB PMC4307283__F4 Lipids regulate apoptotic signaling in the cells CASP9 CASP14 CASP8 CASP6 CASP5 CASP4 CASP3 CASP10 PMC4519426__F5 Genome-wide mapping of DNA hydroxymethylation in osteoarthritic chondrocytes TGFA PCNA LNX2 SMAD2 MPDZ SMAD4 NUMB PTEN ATF2 MAP2 SKP2 CTNNB1 FZD8 ETFA ADAM17 MIB2 SRR FZD1 DLL3 HDAC2 HES7 VEGFA FURIN HRAS CD44 DEK RBX1 HBEGF RICTOR MAP3K1 GRB2 SMURF2 PMC5374431__F1A Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks DVL1 GAP43 RNF7 PML PTEN MYC VAMP4 CSNK2B CTNNB1 HDAC3 NOLC1 UBTF EIF3F SPIB CSNK2A1 GGA1 HDAC2 TOP2A UBC JUN SIN3A APOE PTPN1 SNCA DVL2 FOS PACS1 CHD3 HDAC1 SEC63 PAF1 PAFAH1B1 SUPT16H SAP18 SUDS3 APEX1 RELA SSRP1 NFKBIA CALM1 DVL3 SIRT1 PMC5779957__F8 The top one Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of miR-146a-5p, hsa05200: Pathways in cancer LPA TH CRK PMC6691931__F3 CD40 signalling pathway CD40 STAT3 LTA FCER2 MAPKAPK2 JAK3 TANK TRAF3 TRAF6 TRAF5 ATF1 TRAF1 TRAF2 PMC7277573__F3 “Clathrin-coated vesicle cycle” pathway was enriched in both sexes RILP VAMP2 ARF1 YKT6 BIN1 PREB SNX9 EEA1 VAMP8 VAMP4 VAMP7 PICALM PMC5910217__F2 Interferon system CGAS MAVS STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IRF7 JAK1 TYK2 PMC8424549__F4 Regulation and metabolic functions of mTORC1 and mTORC2 MTHFD2 HEL107 CAD RPIA OMP IMPDH2 HEL-S-70p MYC PMC8424549__F7 Regulation and metabolic functions of mTORC1 and mTORC2 RHEB TFEB PTEN MTOR HTT PMC3948775__F2 Pathway Based Analysis of Genes and Interactions Influencing Porcine Testis Samples from Boars with Divergent Androstenone Content in Back Fat CYP21A2 HSD17B3 CYP17A1 SULT2B1 HSD3B1 HSD11B2 HSD17B1 CYP7B1 HSD17B7 STS HSD17B12 PMC7092451__F6 KEGG pathway analysis of targeted genes involved into proteoglycans in cancer pathway DDX5 EZR ACTG1 HCLS1 PIK3R5 SOS2 PMC3948775__F9 Pathway Based Analysis of Genes and Interactions Influencing Porcine Testis Samples from Boars with Divergent Androstenone Content in Back Fat TES AGA PMC8230743__F13 Gene Expression Profile and Co-Expression Network of Pearl Gentian Grouper under Cold Stress by Integrating Illumina and PacBio Sequences BAD FAS CRTC2 GIP MTOR HEL-S-30 INS EIF4E RHEB PGC TSC2 PYGL PDE3B INSR F2 HEL-S-5 PFKL SIRT1 CIT PMC6359475__F1 Extrinsic and intrinsic pathways of apoptosis BAX FADD PMC8230743__F12 Gene Expression Profile and Co-Expression Network of Pearl Gentian Grouper under Cold Stress by Integrating Illumina and PacBio Sequences FAS POC1A CD36 BNIP3 INS SKP2 RHEB TSC2 RARA IGF1 ATG12 INSR F2 CDK2 ATM CFTR NLK MDM2 PMC7522985__F1 Biosynthesis and Metabolism of n-6 PUFAs and LC-PUFAs TES ACSL5 COX1 LTC4S LPCAT3 MBOAT7 FACL4 GLA FADS2 MGLL FADS1 ACSL1 PTGIS C2 COX2 HEL-S-5 ALOX15 PTGES ADA PMC8102494__F1 Conserved apoptotic pathways BAX FAS TNF FADD PMC9612159__F2 Nano-Based Drug Delivery Systems for Periodontal Tissue Regeneration RGS12 SIRPB1 OSCAR RGS10 NFATC1 PMC8869658__F1 Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in Cordyceps militaris APRT NT5E ADK ADA PMC7956574__F3 Wnt/Beta-catenin signaling pathway in osteogenesis APC GSK3B RUNX2 SFRP1 CTNNB1 PMC7956574__F2 BMPs and TGFB signaling pathways in osteogenesis SMURF1 SMAD2 SMURF2 RUNX2 PMC5555817__F2 Association analysis between chemical activity in the p53RE assay and chemical-induced increased expression of downstream genes in the p53 signaling pathway ATR ATM MYC PMC4034436__F1 Effects of the HIF pathway on mesenchymal stem cells (MSCs) MSC CXCR4 RUNX2 PMC3627370__F1 NAMPT in mammalian NAD metabolism NRK NAMPT PMC12175451__F1 Circadian clock entrainment pathways NPAS2 PER2 CRY2 CRY1 RORA PMC8720586__F3 Target Deconvolution of Fenofibrate in Nonalcoholic Fatty Liver Disease Using Bioinformatics Analysis BAX RARA CEBPA LEP INSR RELA ATF4 INS PMC12175451__F2 Related signaling pathway STAT3 PER1 TLR4 CRY1 MDM2 GADD45A PMC9005294__F3 Involvement of WDHD1 in the Occurrence of Esophageal Cancer as a Downstream Target of PI3K/AKT Pathway BAD PI3 MMP2 PTEN MDM2 MMP9 PDK2 PMC12232070__F12 Mechanism of RME inhibiting the secretion of inflammatory factors by regulating the Dvl1/Wnt1/Beta-catenin/GSK-3B signaling pathway in the treatment of RA DVL1 APC LRP5 WNT1 LRP6 CTNNB1 PMC2597184__F2 Nuclear Factor-kappa B Signaling in Skeletal Muscle Atrophy CD40 LTBR RELA RELB TNF PMC5181590__F3 Specific intracellular signalling pathways are predicted to be abnormally activated in resting HD monocytes STAT3 TLR4 CD14 MYC PMC3491070__F3A Cancer Cell Metabolism: One Hallmark, Many Faces PTEN MYC VHL PMC1951379__F6 IFN signaling during the clinical evolution of SARS STAT1 STAT2 IFITM1 IFIT3 TAP1 JAK1 TYK2 CP PMC5376075__F3 TRL2 pathway is activated by Tollip and results in IRAK suppression TIRAP RELA IRAK1 TRAF6 IRAK4 MYD88 PMC8232321__F2 BMP Pathway in Blood Vessel and Lymphatic Vessel Biology MAX EFNB2 TMEM100 BMPER VEGFA PMC8232321__F1 BMP Pathway in Blood Vessel and Lymphatic Vessel Biology SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 PMC10531420__F6 Seasonal Developing Xylem Transcriptome Analysis of Pinus densiflora Unveils Novel Insights for Compression Wood Formation CAD PRX PMC4554190__F3 Illustration of data-enhanced Bayesian network inference MAPK1 SOS1 NRAS KLK3 MAP2K1 PMC4495315__F1 Signaling via the IGF-1R begins with binding of its ligands, IGF-1, IGF-2, or insulin, to the extracellular Alpha-subunit, and this in turn leads to phosphorylation of the intracellular Beta-subunits JUN BAD IGFBP1 IGFBP4 IGFBP2 PTEN IGF1R IGF2 FOS IGFBP6 IRS1 TSC2 IGF1 IGFBP5 GRB2 PMC3405133__F3 Identification of Pathway Deregulation – Gene Expression Based Analysis of Consistent Signal Transduction TCF7L2 JUN TCF7L1 MYC CCND1 LEF1 FOS PMC8630469__F1 Wnt/Beta-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways LEP APC GSK3B CTNNB1 PMC3646329__F2 HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer TSC2 TSC1 EGFR BRAF PTEN KRAS PMC7892973__F2 Role of irisin-involved integrin signaling cascade in modulating tumor microenvironment remodeling STAT3 FNDC5 CD81 TLR4 ARHA MTOR TRAF6 MYD88 PMC8283807__F10 MitoROS-PKCG-mediated endoplasmic reticulum stress (ERS)-dependent induction of the TXNIP/NLRP3 signaling axis NLRP3 TXNIP ATF4 PMC7241820__F8 Long noncoding RNA PAHAL modulates locust behavioural plasticity through the feedback regulation of dopamine biosynthesis HAL PAH PMC7373860__F5 Frequently altered cancer pathways for TP53 using gene set enrichment analysis pathway enrichment in hepatocellular carcinoma HEL-S-103 BAX ATR BAD FAS E2F2 RASGRF2 RBL2 CDKN2B FLNA RB1 CDKN2A CSF2RB CDK6 CCNE1 MAP2K6 E2F4 CDKN1B BCL2L14 CDK2 CCND1 CDK4 PMC11806886__F5 Combination strategy to suppress tumor cell proliferation in anti-HER2 resistant PTEN-deficient breast cancer cells CD36 FASN PTEN MTOR PMC7840025__F1 Association of a novel endometrial cancer biomarker panel with prognostic risk, platinum insensitivity, and targetable therapeutic options AURKA BRIP1 PIK3CA RAD50 ESPL1 MASTL RAD51 PIK3IP1 BRCA2 GSK3B PIK3R1 EZH2 PTEN CCNA2 PLK1 SKP2 CIP2A FOXM1 MRE11A CCNE1 BRCA1 HCTP4 PMC2794539__F5 Gene Expression Signature of Invasive Potential in Metastatic Melanoma Cells JUN CTSH NGFR PLAUR HRNR APOE NRP2 DCT SNCA CPNE1 TCF4 VCAN SORT1 TMC6 MAPK10 UNK PMC5138060__F1 TNF axis in cancer progression and metastasis TRADD TNF TRAF2 FADD PMC6863034__F4 (A–C) The most significance predictive genes for renal ischemia-reperfusion injury (IRI) in the rat model STAT3 THBS1 CXCL1 CD14 CLEC4D RAP2B MYC CCL2 FLNA CD44 ITGAM LOX IGF1 ITGA6 MMP3 ADAM8 PMC10297376__F2 PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds BAD ULK1 PTEN MTOR RHO DEPTOR EIF4E RHEB MLST8 TSC2 RICTOR TSC1 SESN3 CCND1 PMC6927050__F8 Schematic diagram of hypoxia-induced pyroptosis in myoblasts GSDMD NLRP3 PAX7 PMC1832150__F1 CoQ10biosynthetic pathway with eight known biosynthetic enzymes denoted as COQ1-8 COQ7 COQ3 COQ2 COQ6 COQ5 PMC8589438__F1 Anti-cancer drugs often work by the induction of apoptosis BAX BAD BMF PMC3237753__F7 GAq - Ca2+ signaling pathway promotes actin-mediated epidermal wound closure CDC42 RHO PMC11984396__F3 Diagram of cellular immunity mediated by splenic immunocytes TH HEL-S-92n APC PMC5891205__F9 Radioresistance is associated with G2/M arrest and repression of apoptosis pathway by upregulation of Bcl‐XL, Bcl‐2 and CyclinB1/CDK1 and downregulation of p53, p21, Bax, Caspase‐3 and cleaved PARP in colorectal cancer (CRC) BAX RBBP6 CCNB1 PMC4451058__F2 Prostaglandin pathways in duodenal chemosensing PGP NOD2 CFTR DUOX2 PMC8688651__F1 Network map of apelin-mediated signaling POR SPOP MAK MAL RELA SPG20 ACACA PMC5656035__F3 Proximal components of the TNF signaling pathway TRADD TRAF1 TRAF2 FADD PMC7434656__F2 Interactions of TGFB and RAAS signaling SMAD2 SMAD4 CTGF PMC4448615__F1 Plant and yeast cell walls (CWs) TSC2 TSC1 PMC8628488__F2 Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides INSR GSK3B PDK2 PMC5966782__F1 Glucose catabolism PHGDH PSPH PMC5536941__F3 APC-dependent role of CtBP in the Wnt/ Beta-catenin pathway APC LRP5 LRP6 CCND1 PMC11984396__F8 Activation of CAP by electrical cervical nerve stimulation and splenic ultrasound stimulation to combat inflammation TH ChAT PMC6592229__F2 Inhibition of DNA end resection promotes cNHEJ.DYNLL1, shieldin and UBQLN4 inhibit DNA end resection thereby promoting DSB repair by cNHEJ RAD51 MRE11A DNCL1 BRCA1 BRCA2 RIF1 PMC11984396__F6 Molecular mechanisms underlying neuro-immune interactions VIP STAT3 TRPA1 FPR1 TRPV1 TRPM8 PMC6592229__F1 Balancing DNA double-strand break (DSB) repair.Homologous recombination repair (HR) and classical non-homologous end joining (cNHEJ) are orchestrated in a balanced DSB repair response RAD51 BRCA1 BRCA2 PMC4764462__F2 Transcriptional control of cardiac fibroblast plasticity KLF15 SMAD2 TRPC1 KLF5 ARHA TRPC6 TRPC3 CTNNB1 PMC3484588__F4 Cellular affects of TNFA.Tumour Necrosis Factor alpha (TNFA) is produced by macrophages, lymphocytes, fibroblasts and keratinocyte CD40 TRADD TNF TRAF2 FADD PMC11670415__F1 Necroptosis activation in AD RIPK3 MLKL RIPK1 TNF PMC3482685__F2 Regulatory function of TIR8/SIGIRR in signaling TLR3 TLR4 TLR9 SIGIRR TLR5 TLR7 MTOR CCND1 MYD88 PMC9237949__F7 Modularisation of published and novel models toward a complex KIR2DL4 pathway in pbNK cell SYK LYN GRB2 PMC12027629__F1 Keratinocyte-derived EVs modulate immune cells and promote inflammation in psoriasis IFNG CXCL5 CXCL1 CXCL6 CXCL8 CXCL3 TGFBR1 PMC6895929__F2 Molecular networks enriched by miRNAs differentially expressed in H1299/mutant p53R273H cells ACP2 RPS15 ARHG MAFA EPHB6 SLC38A1 NTRK3 SGCA MAD2L1 GALNT7 VCAN BAMBI TRPS1 NAPG SUFU LAMB3 C10orf104 MIOS PMC9237949__F1 Modularisation of published and novel models toward a complex KIR2DL4 pathway in pbNK cell KIR2DL4 SYK HLA-G HEL-S-11 LYN GRB2 PMC4976833__F1 Cell density regulates cancer metastasis via the Hippo pathway MOB2 LATS2 AMOT PMC5095034__F7 Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification STAT3 IGF1 CXCR4 PMC11560455__F1 Ferroptosis signaling pathway TF TFRC LOX SLC40A1 STEAP3 GPX4 LPCAT3 FACL4 DHODH PMC8913698__F8 Co-functioning of 2AP precursor amino acids enhances 2-acetyl-1-pyrroline under salt stress in aromatic rice (Oryza sativa L.) cultivars DAO PMC7403513__F11 The impact of CFTR dysfunction in HLMVEC on oxidative stress, inflammation and angiogenesis EGFR CFTR PMC8991687__F1 Targeting Chemokine Receptor CCR1 as a Potential Therapeutic Approach for Multiple Myeloma CCL3 DKK1 RUNX2 PMC9285118__F1 Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer GSDMD NLRP3 IL1B PMC5567913__F9 Graphical summary of the results TBR1 SMAD2 SMAD4 NOX4 PMC9285118__F2 Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer GSDMD GZMA GSDMB PJVK DFNA5 GSDMA PMC3133824__F2 Mechanisms for import and export of proteins to and from the nucleus NTS RAN MB PMC3133824__F1 Cytonuclear signaling pathways in MSNs HEL70 PMC7716119__F4 Differentially expressed mRNA of the ceRNA network was significantly enriched, to create a meaningful MAPK and FoxO signaling pathway map MAX ECSIT STAT3 EGF KLF2 FAS CD14 SMAD4 BNIP3 CYC1 PTEN IL6 INS SKP2 DAO BTK IGF1 INSR CDK2 ATM NLK MDM2 MIP PMC4344212__F4 Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing PAX4 MNX1 MAFA BACE1 TCF2 FOXA3 NEUROG3 IAPP PSENEN MME PDX1 NKX2-2 NR2A2 IL18 APP GCK NR5A2 HES1 PKLR HHEX NEUROD1 SLC2A2 HSD17B10 NAE1 BACE2 TNF PAX6 NKX6-1 ONECUT1 NR2A1 HEL-S-162eP PSEN2 CASP3 FOXA2 PMC8570012__F1 Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance STAT3 EGF HIC1 CXCR1 CXCL1 MSC CCL5 CXCL10 CCL8 PMC9446437__F3 Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development HGF EGFR THBS3 MUC1 PTEN GRB2 MTOR EFNA1 SRC CTNNB1 PMC8226806__F2 Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension KLF4 BMPR2 CXCL12 MSC SHH CXCR4 FGFR2 PMC11938631__F6 Mechanisms of Shh signaling pathway in maintaining BBB integrity PTCH1 SHH SMO PMC9601273__F4 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer NR1i1 GSK3B LRP5 LRP6 CXCR4 CCND1 CTNNB1 PMC11612781__F3 From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling VIP EGR1 PER1 CRY1 PROK2 GRB2 EGR2 AVP PMC11938631__F8 Major common pathways regulating BBB integrity after TBI and in AD PTCH1 SHH SMO MMP9 MTOR PMC11938631__F3 Multifaceted roles of TGFB signaling in BBB integrity TGFBR2 SMAD2 SMAD4 TGFBR1 PMC9666724__F4 Functional and clinical characteristics of focal adhesion kinases in cancer progression VEGFC CCL7 CCL5 CXCL10 SRC PMC11938631__F5 Activation of the Wnt/Beta-catenin signaling pathway maintains the BBB integrity APC CTNNB1 PMC9666724__F6 Functional and clinical characteristics of focal adhesion kinases in cancer progression LATS1 HDAC1 LATS2 EGFR ARHA HDAC2 PMC9601273__F3 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer STAT3 EGF EGFR SOCS3 VEGFA PMC4183521__F5 Neuroendocrine Humoral and Vascular Components in the Pressor Pathway for Brain Angiotensin II: A New Axis in Long Term Blood Pressure Control TPR TRPC6 AVP PMC7998619__F2 Viral immune evasion in the placenta utilized by cytomegalovirus (CMV) and Zika virus CD80 MAVS IRF9 TLR9 IRF3 IRF7 IL6 TNF CCL2 CXCL8 MYD88 TLR3 TLR7 PMC9601273__F2 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer MTDH CXCL1 SAFB CXCL2 VEGFA GNA13 PMC9601273__F1 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer CCL19 CCR7 SRCIN1 VEGFA SRC PMC8861501__F7 Integrative Analysis of the lncRNA-Associated ceRNA Regulatory Network Response to Hypoxia in Alveolar Type II Epithelial Cells of Tibetan Pigs IFNG ENO1 PFKL HEL-S-87p H1-0 PMC2683871__F6 p53-regulated pathway analysis using the Ingenuity Pathway Knowledge Base (IPKB) PLK2 DDIT4 CD82 TANK PEG3 PHLDA1 CCNH CYFIP2 AK1 CSTF1 THBD MMP3 HMGN2 S100A4 TP53INP1 KLF6 PERP ZNF148 JMY TSG101 PC4 NR3C1 CCNE2 NFKB1 SESN1 PMC4021575__F3 Ribosome assembly and Insulin signalling pathway RHEB TSC2 BAD LTA FAS INSR SI HEL-S-11 INS PMC1769521__F2 Senescence via tumor suppressor pathways BMI1 TBX2 CDK6 PML CDK2 MDM2 CDK4 PMC6943030__F2 Section from a pathway that describes the biosynthesis of Lewis-type epitopes by the bacterium Helicobacter pylori HP GALP PMC8625890__F8A Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review BAX MSH6 BAD POLK APC CASP3 SMAD4 GRB2 ERG PMC4948992__F3A Regulation of biomechanical signals by NFKB transcription factors in chondrocytes NOS2 COX2 IL1B PMC2780914__F3 Transmigration causes differential expression of genes in the apoptosis pathway NAIP CAD ROCK1 GAS2 TNF PMC7446622__F1 Inflammation during SARS-CoV-2 infection.SARS-CoV-2 invade host cells with angiotensin-converting enzyme2 (ACE2) receptors present on the cell surface membrane NLRP3 TLR4 MYD88 PMC7446622__F4 Putative role of Gsk-3 in the SARS-CoV-2 replication and COVID-19 pathogenesis.Activated Gsk-3 phosphorylate the nucleocapsid protein of SARS-CoV-2 and support viral genome replication and transcription TIRAP KEAP1 TRAF6 CTNNB1 MYD88 PMC7446622__F3 Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic TF VWF TLR4 PMC8838156__F1 Toll-like Receptor 4, Osteoblasts and Leukemogenesis; the Lesson from Acute Myeloid Leukemia TLR4 CD14 IRF3 TRAF6 MYD88 PMC9099292__F7 Transcriptome Analysis Reveals the Molecular Response to Salinity Challenge in Larvae of the Giant Freshwater Prawn Macrobrachium rosenbergii HMGB2 PMC3355540__F2 Nuclear receptors and photoreceptor differentiation in mice CRX NR2E1 SALL3 NR2E3 OTX2 RXRG RORB RORA PMC7476096__F4 Effect of miR-135a on the epithelial-mesenchymal transition (EMT) CDH2 KLF8 CTNNB1 PMC6697794__F8 Schematic diagram represents that leptin signaling-dependent activation of mTORC2/Phllp1/Akt pathway abrogates lysosomal function and negatively regulates macrophage defense during S STAT3 PHLPP1 LEPR PMC7476096__F3 Effects of miR-135a on cancer progression and relevant targets and signaling pathways STAT3 SIAH1 ROCK2 VLDLR EGFR APC KLF8 MTSS1 CTNNB1 BMI1 IGF1 FOXO1 PHLPP2 ROCK1 HOXA10 RBAK CCND1 PMC2855089__F2 NFKB Signaling Pathway TRADD TLR4 TRAF6 TNF MYD88 PMC2643306__F1 Structure-function relationships in methionine adenosyltransferases HEL-S-61p PMC6984792__F8 Mechanism of action of ASB in UV-induced photo-damage in HaCaT cells KEAP1 GCLC IL1B PMC8468723__F3 NUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspective STAT3 PCNA GSK3B PMC4515750__F1 Diversity and complexity of dicer dependent small RNA networks in animals TES AGO2 DICER1 DROSHA PMC4767488__F1 Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis DKK3 APC GSK3B SFRP1 CTNNB1 PMC9654300__F2 Aberrant B Cell Signaling in Autoimmune Diseases SYK CD79B CD79A CD72 CARD11 BANK1 CD22 PTEN CD19 MTOR MYC TRAF6 BLK PTPN22 BTK BCL10 BCR CSK LYN PMC3655383__F2 Importance of white adipose tissue (WAT)–skeletal muscle crosstalk in cancer associated cachexia (CAC) and/or lipotoxicity CD36 G0S2 IL6 EIF2A TNF IL6R IRS1 PMC8918699__F1 Large granular lymphocytic leukemia: a brief review STAT3 FAS SP1 MCL1 FADD PMC5374157__F1 Type I interferons (IFNs) and different other cytokines are essential for natural killer (NK) cell homeostasis and function IL15 IL-21 IFNAR2 JAK3 IFNAR1 IL18 IL2 JAK1 TRAF6 TYK2 MYD88 PMC7872201__F1 Targets of acetylation/deacetylation in metabolic pathways known to affect I/R injury SDHA SIRT3 FH ACO2 HEL-S-5 MDH2 PMC8766720__F6 MiR-27a-3p Targets GLP1R to Regulate Differentiation, Autophagy, and Release of Inflammatory Factors in Pre-Osteoblasts via the AMPK Signaling Pathway GLP1R RUNX2 ATG5 PMC5610088__F1 Phospholipid biosynthetic pathways in Streptomyces LPA PGP PSD HEL-S-5 PMC5763468__F2 MCF7-related generic pathway map HDAC1 BAD INSR BRCA1 EGFR RRM2 BCL2 ATM MTOR PLK1 PMC5291233__F6 Impact of pridopidine treatment on BDNF signalling, AKT activation, and the glucocorticoid pathway EGR1 HOMER1 DDIT4 NTRK2 ARC FOS GPD1 PDK4 CDKN1A NFKBIA MDM2 EGR2 BDNF CEBPB PMC5043072__F3 Targeted proteomic approach in prostatic tissue: a panel of potential biomarkers for cancer detection SPTB SMG1 AGAP2 BRAF MTOR CELSR3 PRLHR INSIG1 MAPKAP1 tmp_locus_29 SP100 ARHGAP21 RYR1 RTKN NR5A2 HTT UBB DTL SYNE2 APC RBL2 DVL2 NCOA1 TUBB PECAM1 TMOD3 TSC2 DMAP1 FOXD3 HEL-S-125m PRKACG COL4A6 PLEC SIRPA YWHAZ PMC5763468__F4 MCF7-specific signaling pathway network inferred by TILP model HDAC1 BAD INSR BRCA1 EGFR RRM2 BCL2 ATM MTOR PLK1 PMC4060203__F1 Schematic showing the details of the estrogen pathway CYP17A1 HSD3B1 HSD17B1 PMC4849044__F2 Schematic diagram illustrates the role of matrilin-3 in ECM modulation of cartilage SMAD1 ADAMTS4 COX2 BMP2 ADAMTS5 MMP3 MATN3 IL1B PMC3094097__F3 Examples of cellular receptors that sense infection and cell death HMGB1 TLR4 TLR9 IRF3 PMC2393790__F3 Citrate cycle genes are up-regulated in the brains of nurse bees ACLY SDHA FH OGDH PC DLD CS PMC155330__F7 slpr, encoding Drosophila MLK, is the MKKK for the Jun kinase pathway during dorsal closure in the fly CDC42 HEL70 ATF2 GCK PMC9091111__F5 Curcumin treats endometriosis in mice by the HIF signaling pathway PPARG EGF JUN FAS NFKB1 GSK3B CASP3 VEGFA FOS PMC9091111__F4 Curcumin treats endometriosis in mice by the HIF signaling pathway PPARG AURKA STAT3 TNFRSF10B MCL1 GSK3B HIF1A HMOX1 BCL2L1 CCNE1 ALOX5 PTGS1 MMP2 HDAC2 NOTCH1 CASP9 NOS2 TRPV1 VEGFA FOS CDKN1A FOXO1 AURKB EGF PCNA EGFR MTOR CTNNB1 LIPC SHBG RARB TLR4 ALOX15 ABCG2 CCND1 TOP2A IL1B CYP1A2 JUN MMP9 PTGS2 IL6 CYP1A1 NR1C1 NFKB1 RPS6KB1 CASP3 NFE2L2 ERBB2 PTGES PMC3657702__F1 Age-related alteration of gene expression in the TCR signaling pathway CD48 ICOS CBL FYN BCL10 LAT ITK CTLA4 GRB2 LCK PMC11580395__F2 Interaction between the sonic hedgehog signalling pathway and other molecular pathways RHEB TSC2 TSC1 SUFU APC GSK3B SHH SMO MTOR SFRP1 CTNNB1 GLI3 PMC11580395__F1 SHH pathways in tumorigenesis and their types (canonical and non-canonical) CDON BOC SUFU SHH SMO CCNB1 GLI3 PMC5438149__F7 Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro GCM1 RHO RAC1 PMC3565545__F10 CHEK kinase pathway showing the role of CHEK proteins in cell cycle checkpoint control, and crosstalk with other pathways notably the P53 and BRCA pathways.Notes: Double circles indicate complex interactions involving multiple genes HUS1 ATR RAD50 RAD1 PCNA BRCA1 CDK2 ATM PMC11857725__F2 The metabolic pathway of tryptophan and phenylalanine in ADHD TH PNMT KYNU DBH AANAT PAH ASMT DDC PMC9249328__F8 Identification of VdASP F2‐interacting protein as a regulator of microsclerotial formation in Verticillium dahliae VTA1 F2 RAC1 PMC11364484__F2 TGFB and BMP receptors and their signaling pathways BMPR2 SMAD1 ACVR2A DKFZp781O1323 ID2 BMPR1A SMAD2 SMAD4 ACVRL1 ID1 PMC7808269__F5 c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy PLSCR1 MARCKS CMPK2 MYC CCL2 CTSC STAT1 NOCT INHBA CD9 MAF CCL7 KDR IL18RAP ETV5 NOS2 PIM2 STAT2 IRF9 APOE IRF1 IRF7 OAS3 ARL4C GPR84 HEL110 VCAM1 LCN2 IL12B HIVEP2 ITGB5 IL15 HEL57 IGFBP4 PROCR CCR3 CCND2 IL18 GADD45B MX2 MX1 DUSP16 IL10 THBS1 IL12A PSMB8 KYNU KMO IRF4 CHI3L1 TLR1 STAT4 HP IFNB1 TNFSF10 GPR183 ICOSLG CD40 HLA-DOA IL27 MYD88 GBP4 IF2D USP18 OASL CH25H BATF CSF2 IFITM2 ANGPTL2 TREML2 RSAD2 PRTN3 VCAN MCM10 RXRA SLFN13 AK4 GADD45A SLFN12L CP ADAR HGF IKBKE PML IFIT2 DHX58 CSF3 TRIM21 ISG20 CSF2RB IL2 ELANE GBP2 IL1B DUSP8 ZFP36L2 JUN ITGA4 IFNA4 MMP9 HDC REL GJA1 PF4 PMC7808269__F4 c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy CD40 TREM1 CCL22 LTA VLDLR CD72 NFKB2 S100A8 CCL5 CCL2 CXCL3 FBXO32 CSF3R GPR18 DPP4 ISG15 MARCO CEBPB CCND1 CCL3L3 MEFV RASGRP4 TUBA1A NMI S100A4 SIGLEC9 CLEC12A SLAMF8 ARG1 FABP4 MMP9 IL6 CXCL6 TNF CXCL10 TNLG2B c-fgr CYP11A1 FPR1 DDIT3 FPR2 CCL4 STAP1 CORO1A VCAM1 CXCR4 TREX1 S100A9 PMC10506516__F6 Schematics of proposed pathway for beneficial effects of L-carnitine on lipid parameters NR1C1 HMGCR CPT2 PMC2597730__F7 Cascade between VEGFA, a direct target of BP1, and its downstream target genes in cell proliferation GRPR CGA PER2 BPI CRH BRAF ID1 ERBB3 PLAT PDPK1 MB SMARCA4 SELP PMC9234279__F6 Methyl Gallate Suppresses the Migration, Invasion, and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells via the AMPK/NFKB Signaling Pathway in vitro and in vivo MMP2 MMP9 PMC7848207__F2 Mechanisms of action and signaling pathways of SIRT1 in diabetic nephropathy HIC1 KEAP1 FOXO1 EZH2 NOX4 SIRT1 CTNNB1 CLDN1 PMC11667996__F3 EBV-Driven Oncogenesis: Manipulating MAPK Signaling and Apoptotic Pathways: EBV promotes tumorigenesis through the MAPK signaling pathway, manipulating host cellular mechanisms DUSP8 SP1 TNLG8A EPHA4 CD47 PMC11830326__F6 Signaling pathways involved in repurposing drugs in cancer therapy STAT3 DAP MDM2 MTOR PMC11667996__F2 Oncogenic Role of H ARHA GRB2 SRC PMC11667996__F1 Activation and signaling pathways of the MAPK Cascade: an overview of stimuli, cascades, and downstream targets: this detailed illustration outlines the four central signaling pathways within the MAPK framework: ERK5, ERK, JNK, and p38/MAPK TSC2 TSC1 SP1 IRAK1 GRB2 TRAF6 IRAK4 PMC8651430__F2 Recent Advances in the Endogenous Brain Renin-Angiotensin System and Drugs Acting on It ACE2 PMC6170679__F7 Model summarizing the proposed signaling events in the myeloid CXCR4 deletion mice IFNG FAS CXCR4 PMC11830326__F3 Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers JAG2 LEF1 CTNNB1 GATA3 PMC11830326__F2 Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers SMAD2 SMAD4 ZEB2 CTNNB1 PMC11830326__F5 Dietary phytochemicals targeting Wnt, TGFB, JAK/STAT, NOTCH, PI3K, and TNFA signaling pathways involved in EMT transitions SMAD2 MTOR TNF GATA3 PMC9270757__F3 Regulatory function of DNA methylation mediated lncRNAs in gastric cancer CDH2 DNMT3B ACOT7 PCDH10 MED18 SP1 HOXA13 SNCG EGFR PTEN CTNNB1 RUNX3 PMC11830326__F4 Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers SNAI2 SMAD2 GSK3B SMAD4 TFG HEL-S-28 ZEB2 ARHA CTNNB1 PMC6827018__F8 Schematic representation of the entire signaling pathway TF LATS2 FOXC1 PMC8589460__F1 Therapeutic strategies targeting Wnt/Beta-catenin signaling for colorectal cancer (Review) APC GSK3B LRP5 LRP6 MYC CTNNB1 PMC3807052__F1 Migration of opioid-containing immune cells and opioid release within inflamed tissue CXCL8 IL1B PMC3111743__F6 Correlation network among processes with activity modified by both OEA and KDS-5104 treatments is shown FAS LOX CD36 PMC7938465__F5 Re-analysis of 15 selected genes via KEGG pathway enrichment analysis BAX CASP9 TSC2 ATR AIFM2 PERP SIVA1 CASP3 ATM PTEN MYC PMC8306455__F5 Evasion of the Host Immune Response by Betaherpesviruses BAX EGF TBK1 CGAS EGFR IRF3 MTOR TRAF3 TRAF6 MYD88 TLR3 TLR4 BCL2 FADD PMC8306455__F4 Evasion of the Host Immune Response by Betaherpesviruses BAX EGF EGFR BCL2 PTEN MTOR FADD PMC7938465__F3 Protein-protein interaction (PPI) network of DEGs FCN2 HEL164 VNN1 CNTN3 CYP2A6 SPINK1 HHIP BUB1B NEK2 HEL-S-4 ROBO1 LPA AKR1D1 C9 MT1M HAO2 CDKN3 GPM6A BCHE GHR DCN CRHBP FCN3 CYP2A7 DTL HAMP CXCL14 SULT1E1 APOF CYP2B6 ALDOB IGF1 CYP2C9 GLS2 TTC36 CXCL12 HGF GYS2 ADRA1A HMMR CTHRC1 PRC1 CCNB1 TOP2A CYP26A1 CLEC1B CDC2 NAT2 CYP1A2 SRD5A2 HGFAC ECT2 KMO RRM2 IGFALS CXCL2 SLC22A1 GPC3 CNDP1 IDO2 SPP1 CAP2 ACSM3 SRPX PMC8306455__F3 Evasion of the Host Immune Response by Betaherpesviruses TBK1 IRF3 TRAF3 TRAF6 MYD88 PMC8306455__F2 Evasion of the Host Immune Response by Betaherpesviruses TBK1 CGAS IRF3 PMC6018831__F3 Metabolic reconstruction of LSUCC0530 BAD MAL CTH CIT PMC7213295__F1 PI3K/AKT/mTOR/NFKB Pathway in Ovarian Cancer RHEB MLST8 TSC2 TSC1 INPP4B PTEN MTOR DEPTOR PMC156240__F1 Xu-5-P is the signal for the coordinated control of lipogenesis HEL-S-162eP HEL-S-5 CIT PMC11172960__F4 Molecular targets of natural product-derived compounds for psoriasis treatment STAT3 STAT1 NLRP3 CEBPD RELA SKP2 CCL20 SIRT1 PMC11172960__F2 Putative molecular targets and their associated signaling pathways for psoriasis in keratinocytes STAT3 HMGB1 FABP5 NLRP3 FRK AIM2 AHR VCP SIRT1 PMC6801309__F1 An overview of myocardial energy substrate utilization CD36 HEL-S-5 CPT2 PMC11172960__F1 Signaling pathways in psoriasis pathogenesis in keratinocytes CXCL9 STAT3 IL17RC S100A7 TRADD S100A8 PTGS2 IL6 CXCL10 CXCL11 STAT1 VCAM1 JAK1 CCL20 TRAF2 TYK2 PMC8027889__F1 AHR and its signaling pathway CYP1A2 IDO1 AIP AHR AHRR CYP1B1 SRC PMC2913337__F2 Cross talk of the Nodal/Cripto-1 signaling pathway with Wnt, hypoxia, Notch, Oct-4, and Nanog signaling pathways GDF3 SMAD2 FZD7 NODAL GDF1 NOTCH1 CTNNB1 PMC4111689__F1 Targeting the Achilles’ heel of drug-resistant cancer stem cells RALB EGFR KRAS PMC6401303__F6 It’s complicated… m6A-Dependent Regulation of Gene Expression in Cancer SOCS2 YTHDF2 PTEN METTL3 PMC3570385__F1 Signal transduction pathway through TLR MAP3K7IP1 TRADD TLR3 TLR4 TLR9 TLR7 TRAF6 TNF FADD PMC9027306__F2 MST1R/RON Tyrosine Kinase in Cancer: Oncogenic Functions and Therapeutic Strategies SIX1 HEL-S-133P HK2 GSK3B GRB2 CA9 CTNNB1 PMC7563658__F1 Canonical and non-canonical nuclear factor K (kappa)-light-chain-enhancer of activated B cells (NFKB) signalling pathways CD40 RELA RELB PMC3759646__F1 Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia ALK IGF1 IGF1R MTOR IRS1 PMC2948541__F5 Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders BAX ATF3 INHBB BTG2 TXNIP FOXO1 NPAS4 SERPINB2 BCL6 PMC6731550__F4 Intracellular pathways targeted by disease pathogenesis in FTLD UBQLN2 WDR41 SMCR8 SQSTM1 OPTN VCP C9orf72 PMC7666787__F7 Role of Tim-3 in breast cancer STAT3 VEGFB VEGFA CCND1 PMC7878551__F6 Hypothetical model for Gram-negative bacteria induced major innate immune response in horseshoe crabs A2M LBP MYD88 PMC9368391__F1 RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections RIPK3 TBK1 ZBP1 MAVS NLRP3 TLR3 MLKL TLR8 IFI16 TLR7 DDX3X MYD88 PMC7343516__F8 Schematic diagrams showing the potential mechanism in the protective effects of Epothilone B on LPS induced inflammatory bone destruction STAT3 CTSK NFATC1 MMP9 PMC9368391__F3 RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections RIPK3 TBK1 MAVS NLRP3 TLR3 TLR8 RIPK1 NOD1 TLR7 IL1B MYD88 PMC6138031__F2 Illustrative model of the IFN signal transduction pathway IFNG STAT1 TYK2 PMC2391069__F1 Overindulgence and metabolic syndrome: is FoxO1 a missing link? TG DGAT1 FOXO1 DGAT2 APOB PDK2 PMC5192062__F2 IL-17 and IL-17 receptor family IL17RC IL25 EBP IL17RB TRAF6 PMC2583496__F2 Global regulation of the E CRP RPIA RELA HP PMC7657662__F2 Schematic depicting the complex I assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded subunits underlined and assembly factors in italics NDUFB6 NDUFB2 NDUFB5 ND4L NDUFB11 NDUFS5 NDUFV2 NDUFA7 NDUFA13 TIMMDC1 NDUFAB1 NDUFA10 NDUFS3 NDUFS6 ND6 NDUFB4 NDUFB1 NDUFA3 ND3 ND2 NDUFC1 ND1 C3orf60 ACAD9 COA1 ZNF183 FES NDUFAF1 NDUFS1 TMEM186 TMEM126B NDUFB8 DMAC1 NDUFA12 NDUFAF8 NDUFV3 NDUFA9 NDUFB9 NDUFA6 NUBPL NDUFS8 NDUFAF6 NDUFAF4 NDUFA11 NDUFS4 NDUFAF2 NDUFB7 NDUFB3 ECSIT TMEM70 NDUFAF5 NDUFC2 ND4 NDUFB10 ND5 NDUFA2 NDUFA5 PMC3321461__F1 Proposed mechanism for overcoming HNSCC resistance to EGFR antagonists using PI3kinase/Akt/mTOR and NFKB-IL6-STAT3 pathway inhibitors STAT3 EGFR IL6 PMC2694580__F2 Biological actions of isoprenoids CDC42 BMP2 ARHA RAC1 PMC6605362__F1 Schematic showing methionine metabolism reactions HEL-S-61p MTR PMC7657662__F4 Schematic depicting the complex III assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded subunits underlined and assembly factors in italics UQCC3 LYRM7 UQCC2 UQCR11 UQCC UQCR10 TTC19 CYC1 UQCRQ UQCRC1 UQCRB C2 UQCRFS1 UQCRC2 UQCRH FES PMC7657662__F3 Schematic depicting the complex II assembly pathway showing known mitochondrial disease genes in red and assembly factors in italics SDHAF1 SDHD SDHA SDHB SDHAF3 SDHAF4 FES SDHAF2 SDHC PMC7657662__F6 Schematic depicting the complex V (F1F0-ATPase) assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded proteins underlined and assembly factors in italics ATP5G1 ATP8 F2 ATP5J ATF1 ATF2 ATP6 APAF1 PMC7657662__F5 Schematic depicting the complex IV assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded proteins underlined and assembly factors in italics FAM36A COX7B TACO1 COX1 COX10 SURF1 PET100 COX7C CSRP2BP TMEM177 COX14 COX17 COXFA4 COX18 COA3 COX8A COX2 COX3 SCO2 HIGD2A CMC1 COA6 COX5A HIGD1A COX16 COA1 COX19 COX11 PMC4845178__F1 Dormancy programs and their potential use in patient treatment RARA SOX9 RARB SOX2 BMP7 NR2F1 PMC4637164__F1 Activation of the complement cascade and its role in tumorigenesis MASP1 C6 C7 MASP2 HEL-S-62p C9 C4A PMC4198062__F8 Possible mechanisms by which phosphorylation of PAGE4 at T51 could potentiate the transactivation of c-Jun but weaken its affinity for c-Jun TXN HIPK1 PAGE4 PMC9667740__F1 Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment MASP1 CD59 FH HTRA1 THSD7A PMC5527958__F1 RTK activation BRAF PTEN MTOR KRAS LBR PMC4026364__F1 Tumor Suppressor p53 and Estrogen Receptors in Nuclear–Mitochondrial Communication TFAM TIGAR SCO2 MDM2 PMC3635737__F8 CCDC22 deficiency in humans blunts activation of proinflammatory NFKB signaling COMMD8 COMMD1 CCDC22 PMC5173152__F6 Wnt/Beta-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling EP300 LEF1 CTNNB1 PMC7462931__F7 Hypothesis how decreased expression of glucose transporters in brain leading to a decreased intracellular d-glucose concentration in neurons may promote the emergence of AD OGA OGT APP PMC7100557__F2 MERS-CoV inhibits innate antiviral signaling RIGI MAVS TLR3 STAT2 IRF9 TLR8 IRF3 TLR7 PMC7947863__F2 LncRNAs regulate CRC metastasis through protein binding HNRNPA2B1 SIAH1 FBXO45 MTOR HNRNPK CTNNB1 PMC11492922__F3 Enriched KEGG terms and PPI network highlight upregulated genes involved in immune response and inflammation CDC42 CCL27 MYB BAD CD69 KLRB1 CYC1 PTEN SNX10 IL6R CD300A COX2 BCR COL4A1 MDM2 TNFRSF12A GAL LCP2 LAMC2 RBL2 CD19 IRS1 RHEB TSC2 SERPINE2 BRCA1 GNG11 PMC3137772__F2 De novo biosynthesis of dolichol phosphate in human SRD5A3 IPP DHDDS PMC2735334__F1 Carcinogenesis of Bcr-Abl in CML BAD BCR BCL2 PMC8172611__F9 Glucocappasalin Induces G2/M-Phase Arrest, Apoptosis, and Autophagy Pathways by Targeting CDK1 and PLK1 in Cervical Carcinoma Cells CDC2 MTOR PLK1 ATG5 PMC6478123__F2 Regulation of fatty acid oxidation, mevalonate pathway, and arachidonic acid metabolism by p53 ACLY FAS PANK1 ALOX5 HEL-S-20 LPIN1 PMC2945811__F1 FA-regulated ICL repair ATR ATRIP FANCM FAAP24 FAN1 PMC12183059__F1 Molecular mechanisms of ferroptosis VDAC3 SLC3A2 KEAP1 GPX4 LPCAT3 FACL4 SLC7A11 HMOX1 IPP LOX STEAP3 GCLC ALOX15 HEL-75 ADA PMC3924162__F2 Signaling pathways in PCSCs BMI1 EGF PTCH1 SOX2 SHH SMO NOTCH2 NOTCH1 CTNNB1 GLI3 PMC3698976__F2 Methionine metabolism: transmethylation pathway HEL-S-61p PMC5064220__F7 Signaling network connecting RAS and mir-200 regulates apoptosis and EMT in cancer cells JUN SP1 BCL2 ZEB2 KRAS PMC5075711__F1 Formal modeling and analysis of ERA associated Biological Regulatory Network in breast cancer BRCA1 EGFR IGF1R MDM2 IRS1 PMC9039220__F3 Challenges and Opportunities Associated With Platelets in Pancreatic Cancer CDH2 BCL2 ARHA MMP9 CCND1 NOTCH1 PMC3743449__F5 Illustration of the hypoxia-inducible factor (HIF) activation pathway, highlighting hydroxylation and acetylation of HIF-1A depending on cellular oxygen tension, that is, normoxia and hypoxia TF EGF HGF TGFA IGF1 MIF MTOR IGF2 IL1B VHL PMC3743449__F4 Classical example of NFKB is the heterodimer of p50 and p65 and the classical activation pathway entails the release from its association with an inhibitory molecule of the IKB family TF IFNG TRAF1 VCAM1 VCP IL1B PMC7459646__F7 Effect of parental Se nutrition on the methionine cycle and transsulfuration pathway in the progeny of rainbow trout HEL-S-182mP HEL-S-61p MTR PMC4508672__F2 HSV-I and the cellular DNA damage response FANCD2 ATR ATRIP RNF168 RNF8 ATM PMC6256264__F7 Schematic summary of molecular mechanisms for duhuo jisheng decoction (DHJSD) on the lower back pain (LBP) caused by Bi Zheng JUN RHO CXCR4 CTNNB1 PMC22464__F5 Metabolic reaction network analyzed from the human erythrocyte containing 29 metabolites and the related 51 fluxes (37 internal and 14 exchange fluxes) TK1 HEL-S-162eP PMC2784255__F1 Examination of Tetrahydrobiopterin Pathway Genes in Autism TH PCBD1 SPR PTS PAH GCHFR CIT PMC3785791__F1 Abbreviated pathway to illustrate cGMP production and its role in oocyte meiotic arrest NPPC PDE3A NPR2 PMC7212408__F3 Notch signaling activity and Hippo pathway in BCSCs LATS1 MOB1A MOBKL1A LATS2 PMC7212408__F2 Activation of MAPK signaling pathway in BCSCs SUZ12 EGF SNAI2 FOXO3A EGFR DUSP9 DUSP16 GATA3 PMC555938__F6 The metabolic shift pathway of yeast Saccharomyces cerevisiae according to the dynamic regulatory modeling in Table 2 ENO2 HEL-S-49 HSF1 FBP1 DEHAL1 PMC555938__F5 Pathway of circadian regulatory system of Arabidopsis thaliana according to the dynamic regulatory modeling in Table 1 CRY2 CRY1 ELF3 PMC8113651__F2 Effect of autophagy modulation on HIV-1 infection LAPTM5 PIP5K1A ATG16L2 PIK3R4 ATG12 ULK1 ARF6 CLN3 ATG5 HDAC6 PMC7420839__F9 Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis CYP26B1 ALDH1A3 RDH10 PMC8113651__F1 HIV-1 modulation of autophagy during early infection and viral non-productive bystander cell contact, and in persistent infected cells/tissues PEX14 RPTOR ARF6 BNIP3 MTOR ATG5 PMC9653672__F6 Analysis of RIOK2 Functions in Mediating the Toxic Effects of Deoxynivalenol in Porcine Intestinal Epithelial Cells BAX SP1 RIOK2 PMC555938__F8 The pathway of metabolic shift regulatory system of yeast Saccharomyces cerevisiae in Fig ENO2 PGM2 HEL-S-49 HSF1 FBP1 DEHAL1 PMC8646547__F2 Suppressor of Cytokine Signalling family of proteins and their potential impact on COVID‐19 disease progression SOCS1 TBK1 MAVS STAT2 IRF9 IRF1 IRF3 IRF7 SOCS3 MYD88 STAT1 TLR3 TLR4 TLR8 TLR7 JAK1 TYK2 PMC555938__F7 Pathway of circadian regulatory system of Arabidopsis thaliana in Fig CRY2 CRY1 ELF3 PMC9069765__F8 EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway PTX3 PBX3 MATN3 CTGF PMC7918761__F1 Methionine cycle facilitates re-methylation of homocysteine to methionine via methionine synthase (MTR) and betaine-homocysteine S-methyltransferase (BHMT) enzymes HEL-S-182mP CTH MTRR HEL-S-61p MTR PMC8700621__F1 Transcriptome Analysis of Induced Pluripotent Stem Cells and Neuronal Progenitor Cells, Derived from Discordant Monozygotic Twins with Parkinson’s Disease NR2F2 BLNK DDX43 PMC9655409__F8 Neuromedin S Regulates Steroidogenesis through Maintaining Mitochondrial Morphology and Function via NMUR2 in Goat Ovarian Granulosa Cells LATS1 NMUR2 LATS2 GAL STAR PMC7140344__F1 Melatonin: new insights on its therapeutic properties in diabetic complications BAX SIRT3 SYK PINK1 MTOR VEGFA IRS1 PMC8700621__F5 Transcriptome Analysis of Induced Pluripotent Stem Cells and Neuronal Progenitor Cells, Derived from Discordant Monozygotic Twins with Parkinson’s Disease FGF8A INHBA NR2F2 DKK1 DLL4 PITX3 WNT7A GRID2 TNF PMC8700621__F4 Transcriptome Analysis of Induced Pluripotent Stem Cells and Neuronal Progenitor Cells, Derived from Discordant Monozygotic Twins with Parkinson’s Disease ATR ARTN TBX20 TBX1 ARC GRID2 TNF PITX2 ISL2 FGF8A INHBA PITX3 TBX3 EGR2 PMC6611507__F4 Emerging role of human cytomegalovirus infection in human carcinogenesis: a review of current evidence and potential therapeutic implications NOS2 EGF CCL18 MYC PMC4992466__F1 Pathways involved in physiological and in the pathological cardiac hypertrophy of calcific aortic valve disease (CAVD) IGF1 MTOR FGF2 PMC6090955__F1 Overview of the IDO metabolic pathway ID2 IDO1 KMO IDO2 PMC8998447__F1 Nutraceuticals as Modulators of Autophagy: Relevance in Parkinson’s Disease LAMP2 ATG12 HEL-S-130P ULK1 MTOR ATG5 PMC6090955__F3 Regulation, function, and targeting of IDO1 in cancer CD80 IDO1 APC KIT AHR CTLA4 MTOR MYD88 PMC2593438__F7 AKT reduces the growth-inhibitory function of TGFB1 TNFAIP2 HEMGN CELSR2 RELA FAM120C COMMD7 PMC10453526__F2 Nodes and tracks of the cholinergic anti-inflammatory pathway STAT3 IL18 TNF PMC6533757__F3 Immunosuppressive effect of the tumor microenvironment CXCL12 CXCL8 PMC4926737__F2 Disruption of postsynaptic differentiation pathway by muscle-specific kinase (MuSK) autoantibodies MUSK LRP4 PMC5901981__F3 Protein Kinase C: Perfectly Balanced C2 CDC37 PIN1 PMC7098175__F5 Antitumor mechanism of Tan I STAT3 BAX CDK2 MTOR KRAS PMC3875633__F4 Invasion gene signaling networks (GSNs) of (A) chronic CNT-exposed and (B) chronic asbestos-exposed MeT5A cells AURKA MMP25 POSTN EGFR RELA CCR4 IGFBP2 SPDEF hEMMPRIN PMC7279300__F2 Signaling cascade of Dectin-1 SYK NLRP3 BCL10 PLCG2 RELB CARD9 PMC9603851__F1 TLR4-Pathway-Associated Biomarkers in Subarachnoid Hemorrhage (SAH): Potential Targets for Future Anti-Inflammatory Therapies TLR4 TAB3 IRAK1 IRF3 IL6 IRAK4 PMC1751079__F1 Inhibitory signals of the Toll-like receptor (TLR)4-induced MyD88-dependent signaling pathway RAN SP1 CD14 SIGIRR IRAK1 IRAK2 SOCS3 TNF TRAF6 IRAK4 MYD88 DOK1 TRAF4 TLR4 PMC8039377__F1 Molecular cascades that create epigenetic memory in HSCs SYK CGAS REST IRF3 IL6 ABCA1 MYD88 RIPK3 IFNG TLR3 AK2 TLR4 ATM JAK1 TREX1 MPP3 IL1B PMC2446520__F1 The GNB/LNB pathway and related enzymes ENG GAL PMC4357331__F1 One-carbon metabolism and methotrexateMTX enters the cell via the reduced folate carrier (RFC) by using an endocytic pathway activated by a folate receptor (FOLR [A, ƴ]) (a) (; ) MTHFD1 RFC1 DHFR SHMT1 MTRR HEL-S-61p TYMS MTR HEL-S-51e PMC5350518__F8 Proposed molecular model of VCAM-1 regulation in ccRCC-VHL–expressing cells RELA RELB VCAM1 REL TNF VHL PMC9081430__F1 Stat3 Signaling Pathway: A Future Therapeutic Target for Bone-Related Diseases STAT3 MSC NFATC1 DLX5 RUNX2 IL1B PMC10919760__F3 Targeted and immunotherapeutic agents screened in GC PDX and PDO models ATR HGF EGFR APC LRP5 LRP6 FGFR2 TSC2 CA3 TSC1 KIF7 SUFU WEE1 SMO GLI3 PMC10931375__F6 miRNAs targeting different components of the WNT signaling pathway to inhibit tumorigenicity FZD8 SCD APC CTNNB1 PMC10931375__F5 miRNAs targeting different components of the WNT signaling pathway to promote tumorigenicity NR3C2 DKK1 APC CTNNB1 PMC4539617__F6 Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma GRPR SHH SMO RHO PMC5700476__F7 NFKB signaling pathway is activated by TLR3/TLR4 TLR3 TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC6375884__F3 A schematic representation of main processes involved in rice drought memory response MYB ERF MYC PMC9656902__F2 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways CDH2 SOX2 NUMB GSC MYC TUG1 HES1 NOTCH1 HES5 PMC9656902__F5 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways HK2 PTCH1 SOX2 SMO SNIP1 GAS1 PMC9656902__F4 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways DNMT3B STAT3 CADM1 SOX4 PMC9656902__F3 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways TH HOXA9 WNT7A EZH2 EHF WNT4 BPTF WNT2B CTNNB1 PMC5795986__F3 Signaling pathways for melanin inhibition by NSC-CM DKK1 LRP5 LRP6 CTNNB1 PMC7681076__F4 Proteaphagy: selective autophagy of inactive proteasomes SNX4 RPN1 CP PMC3839643__F1 Mammalian target of rapamycin (mTOR) -centric view of nutrient sensing for the induction of forkhead box P3 (FOXP3) STAT3 SOCS3 FOXP3 MTOR PMC12254190__F5 MiR-152 in hematologic malignancies, including multiple myeloma (A), AML-NPM1 (B), diffuse large B-cell lymphoma (C), non-Hodgkin lymphoma (D), chronic myeloid leukemia (E), and acute lymphoblastic leukemia (F) BRD4 DKK1 ATP2A2 PMC140043__F8 RelB is required for Peyer’s patch development: differential regulation of p52–RelB by lymphotoxin and TNF LTB LTA LTBR RELA RELB TNF PMC3839643__F3 Enzymes that catabolize or use essential amino acids NOS2 HDC CDO1 HAL BCAT2 BCAT1 ARG1 PAH AASS PMC11216939__F2 Interplay between the PI3K/AKT pathway and circadian rhythm regulators DBP PMC10670053__F1 Most common signalling pathways active in muscle and adipocytes during cancer-associated cachexia IGF1 SMAD2 LIF UCP1 MTOR TNF PMC5141640__F3 Ischemic stroke induces systemic immunosuppression mediated by several factors DRD2 GC PMC5482702__F2 Hypoxia signalling pathway in haematological malignancies EGF TPO PTEN MYC VHL PMC5326762__F2 Pathways of HIF-1A and its target genes involved in retinal neuroprotection HEL164 ADM KEAP1 EPO IRS1 VHL PMC8892079__F1 Structural basis for dysregulation of aminolevulinic acid synthase in human disease CPOX FECH UROD UROS PMC3390419__F1 Caspases and Kinases in a Death Grip BAX FAS BCL2 FADD PMC6896486__F7 Exacerbation between G6PD dysfunction and neuroinflammation mediated chronic neurodegeneration TLR4 TNF PMC11758808__F5 Biosynthesis of ncAAs ICAM3 OBI1 SEPSECS PSTK PMC6279243__F5 Identification of Key Differentially Expressed MicroRNAs in Cancer Patients Through Pan-cancer Analysis INPP5A FRS2 FOXO4 CCND2 AKT3 FGFR4 FGFR1 PIK3R1 PTEN GRB2 IRS1 PMC2279152__F1 Apoptosis signalling pathways HTRA2 BAX CASP3 BCL2 APAF1 FADD PMC7681076__F6 Pexophagy in yeast and mammals PEX14 NBR1 USP30 TSC2 PEX6 PEX5 ATM PEX2 PEX3 PEX12 PEX26 PMC4212313__F1 B cell receptor signalling pathway controls B-cell fate and function SYK BTK FYN PLCG2 LYN PMC6105693__F8 Transforming Growth Factor Beta Signaling in Dendritic Cells Is Required for Immunotolerance to Sperm in the Epididymis SPIC CLEC9A LCP2 CD74 FCGR3A ALOX15 VCAM1 CCL5 TIMD4 HLA-DQB1 PMC3655867__F2 Leptin deficiency disturbs the insulin signaling pathway JAK2/IRS/PI3K/AKT/AMPK and triggers diabetes STAT3 SOCS3 PMC6615313__F6 Metabolic context of the reconstructed σ54 regulons in Clostridiales species ETFA ETFB NHS HBD PMC9119167__F4 Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins OSBP ABCG1 NPC1 PTMS ABCA1 PMC9119167__F2 Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins IPP CH25H CYP46A1 CYP7B1 CYP3A4 CYP27A1 MVK PMC7288675__F2 Regulation of the microbiota in adaptive immunity IL23R PMC11034608__F7 p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model FTL GPX4 SLC7A11 PMC7269988__F2 ER stress and the activation of the three UPR pathways ATF4 EIF2A XBP1 TRAF2 PMC8720965__F4 Disorders of Sex Development of Adrenal Origin POR AKR1C2 PMC6528915__F2 Overview for the regulatory mechanisms upstream and downstream of ZEB1‐AS1 in cancer progression BMI1 STAT3 BAX MMP2 CDK2 MMP9 PMC7249489__F3 Signaling Pathways in Leukemic Stem Cells APC GSK3B LRP5 LRP6 CTNNB1 PMC4638170__F3 Gaining insights into diabetic cardiomyopathy from Drosophila SRI TCP1 FAS PMC7249489__F5 Signaling Pathways in Leukemic Stem Cells TGFB1 PMC7016461__F5 KEGG enrichment analysis of the hub genes TH SP1 APP PMC7249489__F2 Signaling Pathways in Leukemic Stem Cells RHEB TSC2 TSC1 PTEN DEPTOR PMC4303147__F4 Dominant negative LMP1 inhibits proliferation of CAEBV T cells TRADD RELB IRF7 PMC6412627__F1 Synthesis of triacylglycerol (TAG) LPA MGAT1 AGPAT5 HMFN0839 DGAT1 GPAT4 GPAT2 DGAT2 MGAT3 AGPAT3 MGAT2 AGPAT4 PMC6412627__F3 Regulation of the expression and cleavage of sterol regulatory element-binding protein-1c (SREBP-1c) and the transcriptional activation of the acyl-CoA:glycerol-sn-3-phosphate acyltransferase1 (GPAT1) gene IRS1 PMC6154995__F7 Heme-dependent feedback inhibition of ALAS in the heme biosynthetic pathway CPO FECH UROD UROS PMC3591604__F2 GPI anchor synthesis PIGO PIGC PIGF PIGH DPM2 PIGW PIGL PIGK PIGM PGAP1 PMC3865857__F2 Main enzymes and G protein-coupled receptors in the cyclooxygenase pathway PTGDR PTGER2 PTGER3 COX1 PTGIS COX2 TBXA2R PTGER1 PTGER4 PTGS2 PTGFR PTGIR PMC2910015__F4 General view of the species-specific regulation of histone homeostasis CDC2 SLBP NPAT PMC3865857__F1 Conversion of ω6 and ω3 series PUFA by metabolic enzymes and interaction with de novo fatty acid synthesis MLYCD ELOVL2 COX1 COX2 SCD FASN FADS2 ELOVL5 FADS1 PMC11681754__F7 Potential mechanism of LPL-RH in salvaging bone calcium loss in OVX rats TLR4 NFATC1 TRAF6 MYD88 PMC7352853__F2 Sphingolipids implicated in pulmonary fibrosis, their structure, and metabolizing enzymes CERS3 CERS5 SPHK2 CERS1 CERS2 SPHK1 DEGS1 KDSR CERS6 PMC9325518__F1 Role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma LIN28B LIN28A HEL-S-162eP PTEN ENO1 IGF1R MTOR HEL-S-87p MYC PMC8327449__F3 PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression SMAD2 SMAD4 TGIF1 PMC7352853__F6 Role of lysophosphatidic signaling via lysophosphatidic acid receptors in pulmonary fibrosis LPA SMAD2 HEL-S-14 TGFBR3 SMAD4 RHO PMC3785471__F2 Host Response to Respiratory Bacterial Pathogens as Identified by Integrated Analysis of Human Gene Expression Data RANBP2 HSF2 SUMO1 SF1 SP100 UBE2E3 NFKBIA SP3 CS MDM2 SAE1 PIAS2 PMC9508608__F1 Methionine restriction - Association with redox homeostasis and implications on aging and diseases SMS SRM HEL-S-61p PMC9584741__F4 lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway AGXT2 RYR2 TC2N NOVA2 RASGRP3 GABRA4 KLF14 C1orf167 GATD3 CAMK2A CRB2 MUC20 FLT4 LPO KY PDGFRA ABCC9 TSHZ2 PMC7098175__F3 Antitumor mechanism of CT RHEB STAT3 SIRT3 TSC2 BAD IGF1 HEL-S-133P HK2 HIF1A CCND1 CTNNB1 PMC7098175__F2 Antitumor mechanism of Tan IIA STAT3 BAX FOXM1 BAD CTLA4 MMP9 MTOR EIF2A SKP2 NOTCH1 CTNNB1 PMC7397204__F2 PI3K/Akt/mTOR signaling and its interaction with PTEN CENPO TSC2 BAD RAD51 TSC1 CDK2 PTEN MDM2 JAK1 IRS1 PMC11042502__F2 Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD ACAD9 ECHS1 HADHB CD36 ACADS ACADVL ACADL CPT2 CPT1A ACADM PMC9203892__F3 TIGIT as a Promising Therapeutic Target in Autoimmune Diseases CD226 CD80 TIGIT APC PMC8233504__F7 Genomic Architecture of Adaptation to Larval Malnutrition Points to a Trade-off with Adult Starvation Resistance in Drosophila RHEB IDE RICTOR MOB4 TSC1 DENR CDC37 MYC FMR1 STUB1 PMC11040290__F1 Emerging role of galectin 3 in neuroinflammation and neurodegeneration CD44 IFNGR1 IGF1 HEL-S-28 MERTK PMC4061222__F1 Roles of Wnt5a in cancer metastasis- (A) promoting and (B) suppressive processes SIAH2 TLR4 ROR2 ARF6 CTNNB1 PMC2268796__F6 The signaling pathways regulating cell cycle and differentiation in tumor cells in response to shear stress CDC2 SMAD1 DKFZp781O1323 CCNB1 RUNX2 PMC4109802__F2 Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration FGFR1 CD200 FGF2 PMC9305269__F4 Effect of a Functional Phospholipid Metabolome-Protein Association Pathway on the Mechanism of COVID-19 Disease Progression CERK CER1 PC PMC5578430__F1 Innate immune escape by Dengue and West Nile viruses TBK1 CGAS MAVS TRIM25 IRF3 IRF7 PMC8278114__F6 Pro‐inflammatory signals induce 20A‐HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal JUN TLR4 TRAF6 FOS MYD88 PMC7729028__F4 MEKK3–MEK5–ERK5–KLF2/4 signalling pathway CDC42 KLF4 KLF2 ADAMTS4 TLR4 CCM1 IL1B PMC4632280__F7 RAC3 regulates cellular senescence and aging MTOR RAC3 SIRT1 PMC1698527__F10 Model for the transduction of DNA damage signals to the splicing machinery ATR TAF1 TAF4 ATM TAF3 PMC9684653__F3 Targeting the MDM2-p53 pathway in dedifferentiated liposarcoma AURKA TSC2 ATM MDM2 MTOR PMC4384662__F4A PI3K in cancer: divergent roles of isoforms, modes of activation, and therapeutic targeting CDC42 CD40 BCR EGFR CD19 PTEN RAC1 PMC5640931__F2 The mathematical model APC PC CTNNB1 PMC2964935__F5 PAR Proteins: Fundamental Players in Animal Cell Polarization TIAM1 NUMB INSC PTEN RHO PMC3196148__F9 Working model for the ATF4-dependent and c-JUN-dependent AA signaling pathways ATF4 ATF2 EIF2A PMC9445622__F1 Akt isoforms in the immune system CD80 PMC3209670__F3 mTOR signaling pathway affected by pollen feeding or varroa parasitism RHEB ELF4 RICTOR TSC1 BRAF PMC4595834__F7 Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4Beta-S-aromatic heterocyclic podophyllum derivatives display antitumor activity ATR ATM FADD PMC7177758__F1 JNK (C-Jun N-terminal kinase) substrates that regulate the mitochondrial apoptotic pathway BAD ITCH BMF PMC7177758__F3 Positive feedback loops in apoptosis CCND1 PMC9508608__F3 Methionine restriction - Association with redox homeostasis and implications on aging and diseases NR1C1 FGF21 NQO1 ATF4 MTOR SIRT1 MPO PMC4908701__F5 Curcumin regulated signaling networks CDC42 STAT3 TGFB1 EPHA2 SHC1 PXN ANKS1A PIK3R2 TMX1 EPHB2 FYN HEL-S-80p PRKCA PAK6 MAPK12 NRF1 MAPK1 TNK2 ROCK2 SDCBP CRKL PTK2B ARHA PCTK1 ERBB3 HRAS CRK CBL PKP4 BAG3 IL6ST LYN GRB2 PMC7899164__F6 MitomiRNAs interactions with mitochondrial encoded genes either positive or negative suggestively CYB COX1 COX3 ATP6 PMC3579383__F1 Myelin-derived neurite growth inhibitors, their receptors, and intracellular signaling pathway LINGO1 ARHA PMC6698799__F4 Proposed molecular mechanism of regulation of the pyrin inflammasome PKN1 HEL-S-62p IL18 PKN2 RHO PMC4102778__F3 GSK-3 as potential target for therapeutic intervention in cancer RPS6 EIF4B ULK1 PTEN MTOR DEPTOR IRS1 EIF4E RHEB TSC2 RICTOR TSC1 GRB2 PMC11506062__F2 Major metabolic pathways at work within cancer cells HEL107 SCD FASN TIGAR MTOR ACACA SLC7A5 RHEB ACSS2 HMGCR HEL-S-162eP ENO1 GLS2 PMC11506062__F1 Comparison of the major metabolic pathways in (A) normal and (B) cancer cells SLC7A5 MTOR PMC4102778__F7 GSK-3 as potential target for therapeutic intervention in cancer SUFU PTCH1 BCL2 SMO RAB23 CCND1 IGF2 GLI3 PMC3880216__F5 Schematic diagram BAX BAD GSK3B PMC6826683__F10 Strategies for therapeutic intervention of cancer involving FADD AURKA CCNB1 PLK1 KRAS CCND1 FADD PMC7830297__F1 TLR4 signaling pathway TBK1 MAP3K7IP1 TIRAP TLR4 TAB3 IRF3 TRAF3 TRAF6 IRAK4 MYD88 PMC6698799__F3 Proposed interaction model of Yersinia pestis effectors, Yops, with the pyrin inflammasome PKN1 PKN2 RHO MVK PMC4064057__F3 Genotype-specific steatogenic pathways associated with hepatitis C virus infection FAS PTEN SOCS3 PMC2726954__F2 Quest for genetic determinants of human longevity: challenges and insights IGF1 SGK1 PTEN IGF1R PMC7028093__F2 Notch signaling pathway MAML1 MAML3 JAG2 NUMB LFNG NOTCH2 NOTCH3 MAML2 RBPJ NOTCH1 PMC3860372__F1 Metabolic Homeostasis: HDACs Take Center Stage SIK1 NR2A1 SIK3 CRTC2 PMC8095380__F7 Melatonin: Multi-Target Mechanism Against Diminished Ovarian Reserve Based on Network Pharmacology HRAS PIK3CA MYB BAD MAK NOG CHUK RORA PMC6460806__F2 Interactive signaling pathway of EGFR-PI3K-mTOR RHEB RALB RALA EGFR PTEN RHO PMC3981572__F9 Integrative model of the physiogenomic adaptations in adipose and liver tissue induced by energy overfeeding during the last 45 days of pregnancy MLYCD ACOX1 CRAT DGAT1 FGF21 IGFALS SOCS2 ACACA CS RORA NCOR2 NR1C1 ANGPTL4 MTTP IGF1 CROT RXRA APOB ACADVL ADFP GHR PMC9195137__F3 AMH Regulation by Steroids in the Mammalian Testis: Underlying Mechanisms and Clinical Implications TF EGFR SRC PMC6068130__F1 Tryptophan (Trp) catabolic pathways HEL-S-90n IDO1 KYNU KMO PMC9123149__F2 Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock ENPP1 ADA PMC6923668__F1 Mechanism of mutant CALR-induced MPN and approaches for therapeutic targeting MPL HEL-S-99n APC PMC5773610__F7 Mechanism of anti-allergic and inflammatory effect of quail egg on the food allergy induced EoE like disease alergic reaction IL15 TSLP IL6 PMC10886582__F3 Pathways related to activation of pyroptosis NLRP1 GSDMD NLRP3 PMC5640931__F1 Simplified scheme of liver architecture and Wnt/ Beta-catenin signalling APC PC CTNNB1 PMC5883082__F1 Programmed cell death protein 1 (PD-1) mediated intracellular signaling events during T cell activation CD80 GRB2 LCK PMC7000431__F1 Human and mouse bile acid synthesis and conjugation CYP8B1 CYP7B1 CYP27A1 PMC5557697__F3 Model depicting the Cdc42-mediated regulation of EGF receptor interactions with c-Cbl CDC42 EGF CBL EGFR PMC6492897__F2 Ingenuity pathways analysis (IPA) of ASS234 (5 μM) treatment JUN HEL-S-107 PPIB KEAP1 GCLM HEL-S-94n VCP USP14 GPX2 TXN BACH1 CCT7 EPHX1 GCLC MAF CLPP ATF4 HEL-75 UNK UBB PMC10886582__F4 Necroptosis signaling pathway RIPK3 MAP3K7IP1 TRADD MLKL RIPK1 CYLD TRAF2 FADD PMC4128536__F4 STRING analysis of pathway enrichment and interaction in the altered mRNA in rat ARDS S100A4 GNRH1 MT3 RAMP2 TIMP1 ACO2 CES3 EIF2AK1 APC PSMA4 IGFBP6 GP1BB GABRB1 LCT HEL-S-128m FGFR4 HEL-S-32 TSPAN8 LCN2 S100A9 LIM2 PMC5067484__F1 Reelin signaling pathway in the developing cortex CDH2 CRK DAB1 VLDLR CRKL GSK3B MTOR PMC4809675__F1 TNF biology, pathogenic mechanisms and emerging therapeutic strategies TRADD MLKL TNF TRAF2 PMC3251560__F7 Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes STAT3 ADIPOR2 LEPR PRR14 POFUT1 ARHGEF3 RORA TMF1 MKI67 RORC NR2A1 TRIM24 FER INCENP TAOK3 PMC11595909__F2 Signaling mechanism of IGF-1 upon binding to IGF-1 receptor (IGF-1R) BAD IGF1 IGF1R MTOR PMC11595909__F1 Effects of BDNF and NGF on the cell signaling processes that potentially lead to cellular effects with the end results of neuroregeneration or neurorepair NGF BDNF PMC3251560__F9 Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes MAX TRPS1 MYOG DKFZp313J0816 PROCA1 PSME4 SURF2 DKFZp686P0251 PMC3251560__F8 Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes ADRM1 MALL MAGI1 CBX4 PCGF2 TUBG1 SLC1A1 PMC4828918__F1 Figure demonstrates the wide array of interactions present in the Wnt signaling cascade EGFR APC GSK3B LRP5 PEG3 LRP6 PLAGL2 MTOR AXIN2 CTNNB1 RHEB AXIN1 SHH SMO HES1 PMC8718055__F6 Inhibition of the NLRP3/IL‐1B axis protects against sepsis‐induced cardiomyopathy IL1R1 NLRP3 IL1B PMC11595909__F3 LIF signaling mechanism upon binding to LIF receptor that is constituted by LIFRB and gp130 heterodimer LIF MTOR PMC4427718__F3 Biological network capturing the immune response and the metabolism of glycosaminoglycan and sphingolipid revealed from Ingenuity Pathway Analysis® (IPA®) BATF FUCA1 CD27 IL4 GNPTAB LRRC26 HEXA LITAF GNS GALNS ARHGAP21 APP ACR PMC6879915__F1 Apoptosis pathway BAX PAF1 APAF1 FADD PMC7844024__F8 Differential NFKB pathway activation by 65–79*SE and 65–79*PE under M1 (A,B) or M2 (C,D) polarizing conditions STAT3 EGR1 SP1 RELB IRF1 HIF1A MYC TEC STAT1 CEBPA NFKB1 RELA NFKBIA REL PMC6582183__F2 Schematic portrays crosstalk between miR29 family and various signal transduction pathways involved in pathogenesis of Diabetic Nephropathy KEAP1 DPP4 WNT1 CTNNB1 PMC5280013__F8 miR-146a plays a critical role in limiting the inflammatory response to ischemia-reperfusion TLR4 IRAK1 PMC9570317__F1 Advances in Anti-Cancer Activities of Flavonoids in Scutellariae radix: Perspectives on Mechanism CDK6 CCND2 SOX2 GSK3B CDK2 PTEN CCNB1 CCND1 CDK4 CTNNB1 PMC2714185__F3 Major regulatory steps in the process of DNA damage response (DDR) RAD52 ATR RAD50 ATRIP RAD51 MRE11A BRCA1 BRCA2 PML ATM MDC1 PMC8975741__F8 The role of TSPAN6 in the regulation of signaling pathways in tumorigenesis TSPAN6 EGFR SCRIB PMC2714185__F1 Role of ATM in cellular responses FANCD2 RAD50 MRE11A BRCA1 CDK2 ATM MDM2 MDC1 PMC6667928__F3 Therapeutic strategies are involved in heme metabolic pathway HP ABCG2 CD163 PMC6667928__F2 Pivotal functions of the molecules in heme metabolic pathway in inflammation HEL-S-92n SYK NLRP3 TLR4 PMC4594483__F2 TGFB signaling SMAD2 TGFBR3 SMAD4 RHO TGFBR1 PMC7689298__F10 Proposed model of the involvement of TREM2 in the IL-4-induced anti-inflammatory response CLEC7A JAK3 ARG1 TNF ITGAX MYD88 TREM2 IGF1 C1QA TLR4 AIF1 AP1B1 CSF1R PMC3427140__F4 Cross talk between focal adhesion kinase and cadherins: Role in regulating endothelial barrier function KLF4 APC GSK3B CTNNB1 PMC8204012__F1 New Insights Into the Role of Autophagy in Liver Surgery in the Setting of Metabolic Syndrome and Related Diseases NLRP3 TFEB IL18 IL1B PMC7999361__F2 Photoperiodic flowering in Arabidopsis, a long-day plant, and in rice, a short-day plant RFWD2 CRY2 CRY1 EHD1 PMC8701046__F1 Homologous Recombination as a Fundamental Genome Surveillance Mechanism during DNA Replication RAD51B BARD1 RAD51D RAD51C SWSAP1 RAD51 BRCA1 BRCA2 PALB2 XRCC3 PMC9411814__F6 Investigation of the mechanism of the anti-cancer effects of Astragalus propinquus Schischkin and Pinellia pedatisecta Schott (A&P) on melanoma via network pharmacology and experimental verification BAD BCR RBL2 CYC1 CD19 PTEN MDM2 RAC1 IRS1 PMC4878678__F1 Genes in the MAP kinase signaling pathway (MAPK signaling pathway) identified using the KEGG-based pathway visualization tool MAX ECSIT JUN FAS EGFR CD14 TRAF2 PMC5711814__F2 Non-canonical regulation of HIF-1A stability HEL-S-62p PTEN RHO MDM2 MTOR HEL-117 PMC6511038__F3 Enrichment analysis of genes transcriptionally related to morphometric similarity PTGER3 HTR7 NPY1R PDYN NTSR1 OPRM1 GNG2 S1PR1 DRD4 DRD5 ADRA2C 5HT1A EDNRB CNR1 PLCB2 ITPR2 PMC5536018__F4 The alternative splicing and immune function of RLRs-mediated signaling pathways in response to viral infection in teleost fish MAVS IRF3 IRF7 TRAF3 PMC5463089__F2 Ubiquitination mediates the NF‐KB activation and nuclear translocation SUMO1 SUMO2 TRPM1 BRAF HIF1A FBXO4 MDM2 SKP2 CCND1 PMC6314914__F3 Proposed PD-1 & PD-L1/L2 intra-cellular signaling between T cells and/or macrophage/monocytes, among others (e.g CD80 PMC8553822__F2 TLR signal transduction TBK1 TIRAP MAL TAB3 TANK TLR9 IRAK1 IRF1 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 TLR1 MAP3K7IP1 TLR3 TLR4 PDC TLR8 RIPK1 TLR7 TLR10 PMC8782664__F1 LPS versus Poly I:C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring MAVS TLR3 TLR4 TLR9 TLR8 CD14 IRF3 TLR7 TRAF3 TRAF6 ACE2 MYD88 PMC5587604__F5 Hydroquinone suppresses IFNB expression by targeting AKT/IRF3 pathway IRF3 IL1B MYD88 PMC4716143__F3 Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection CRP HEL-S-62p CS C4B_2 PMC2779044__F4 Model describing the regulation of protein synthesis by AMPK, Ca++ and Akt -signaling pathways RHEB EEF2K TSC2 TSC1 EEF2 EIF4E PMC5078051__F6 Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium FOXM1 AURKB PAX8 BCL2 PLK1 PMC8742179__F6 ZNF292 suppresses proliferation of ESCC cells through ZNF292/SKP2/P27 signaling axis ZNF292 RBX1 SKP1 SKP2 PMC7073055__F1 Pathogenetic mechanisms in extranodal NK/T-cell lymphoma (ENKTL) ZAP70 IL10 IFNGR1 LAT JAK3 ELL BCL2 IL2 ITK LCK IL9 PMC8994689__F3 Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases RPE LPO NOX4 PMC8220134__F6 Early Growth Response Family Members 1–4 in Prognostic Value of Breast Cancer EGR1 LHB NFATC2 PARP14 FCER2 CD69 JUNB NFATC1 FOS EGR4 NAB1 GDF15 NAB2 IER2 NFATC3 HOXB2 EGR2 SYN1 CEBPB ABCB1 PMC8399174__F1 H2O2 Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in Aspergillus nidulans CDC42 NAPA HMFT1766 PHKB ARHA PMC10522874__F2 Mature white adipocyte plasticity during mammary gland remodelling and cancer SMAD1 DKFZp781O1323 SUFU APC GSK3B SMAD6 SMAD4 SMO CTNNB1 PMC6470985__F3 Regulation of the mucus production by MAPK signalling JUND TGFA SP1 EGFR FOXA2 MUC4 SRC MYD88 PMC5432547__F4 Action network of predicted targets of miRNAs overexpressed in GML mice stomachs TP53INP1 PTEN EGR2 PMC3911547__F12 Schematic diagram depicting the diverse outcomes of KSHV-induced 5LO and LTB4 in ECs and the consequences and roles of KSHV in viral pathogenesis EPHA2 SRC PMC7457719__F6 Scheme illustration for Au4.5-induced NLRP3 inflammasome activation NLRP3 ATG5 IL1B PMC4269192__F1 Type 3 deiodinase expression on Warburg phenotype HEL-S-133P HIF1A MXI1 PMC10888202__F6 Comparative analysis of DEGs at different growth stages HEL-S-68p HEL-S-162eP PMC11757137__F1 M5C modifications in immune signaling regulation TREX2 TBK1 NSUN2 CGAS MAVS GPX4 TLR9 TLR5 IRF3 IRF7 TRAF3 NSUN5 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 PMC10941471__F7 Graphical abstract LPA SMAD2 PMC5190135__F1 Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development STAT3 HEL-S-8a EGF KEAP1 MMP9 TEF CCND1 CTNNB1 PMC8195365__F8 Tentative mechanistic model for MERS-CoV-induced protective innate immune responses in alpaca respiratory tracts IL15 IL10 CCL3 IRF3 IRF7 IL6 CXCL10 CCL2 STAT1 NLRP3 MX1 ISG15 OAS1 IL1B PMC10150574__F3 Signaling through the phosphatidylinositol 3-kinase (PI3K)/AKT pathway CDC42 STAT3 BAD EGFR GSK3B PTEN MDM2 GRB2 MTOR SRC RAC1 PMC6945844__F3 High Flux Through the Oxidative Pentose Phosphate Pathway Lowers Efficiency in Developing Camelina Seeds MAL HP CIT PMC7681028__F6 Functions and pathways of the type II MAGEs, MAGE-F1 and -L2 VPS29 VPS35 MMS19 MAGEL2 CRY1 LEPR FES RTEL1 PMC8841513__F5 CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and Thromboinflammation TF MAVS NLRP3 IRF3 HIF1A PMC6627878__F2 Kinase signalling pathway JAK3 BCL2 IL7R PTEN MTOR JAK1 PMC11202056__F8 STRING pathway analysis depicting protein–protein interaction (PPI) networks ROBO3 PRSS22 REG3G CXCL13 SCIMP CLEC7A MYOCD ADAM33 HTRA4 NPY2R NAPSA INHBA PLA2G4D HELT MOS ERICH5 TMEM114 STAC2 GPR174 ESPN PMC4412965__F3 Proteins involved in chromosomal fragility ERCC1 FANCD2 HUS1 ATR RAD51 BRCA1 WRN ATM GEN1 BLM POLN PMC4469326__F4 JAK-STAT signalling pathway CBL PIM1 EPO IL6 PMC2715808__F8 Regulation of mTORC1 signaling by mTOR S1261 phosphorylation RHEB MLST8 MTOR PMC7218496__F9 Mechanism of AA on attenuating hypertrophic and fibrotic differentiation ACAN COL1A1 SOX9 COL10A1 RUNX2 COL2A1 PMC4469326__F3 TNF signalling pathway TH FAS TRADD SELE ITCH MLKL IL6 TNF EDN1 NOD2 CASP3 TRAF1 TRAF2 CASP10 FADD PMC4469326__F2 Toll-like receptor signalling pathway coverage CD40 CD80 TIRAP CTSK TLR9 CD14 IRF3 IRF7 TRAF3 TRAF6 IRAK4 RAC1 MYD88 TLR3 LBP FADD PMC10742271__F4 Signaling pathway involved in the osteogenesis process due to Mg effect TRPM7 MAGT1 MSC NFATC1 CREB1 CTNNB1 PMC8294190__F5 Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease? STAT3 FOXP3 TNF PMC8294190__F2 Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease? EGF TGFBI EGFR HDAC2 PMC8294190__F1 Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease? IL17RC IL17RB TRAF6 PMC8773363__F3 Atoh8 in Development and Disease SMAD1 DKFZp781O1323 SMAD6 SMAD4 ATOH8 PMC9242402__F4 Metabolic Regulation of Hematopoietic Stem Cells GOT2 GLS BCAT1 PMC9335447__F5 MicroRNA global profiling in cystic fibrosis cell lines reveals dysregulated pathways related with inflammation, cancer, growth, glucose and lipid metabolism, and fertility: an exploratory study PNP EGFR ME1 FECH PMC8580782__F0 Erythrocytosis: genes and pathways involved in disease development EGLN1 HEL-S-133P HEL-S-68p CREBBP EPO MMP9 VHL PMC8539415__F1 Metabolic Perturbation and Synthetic Biology Strategies for Plant Terpenoid Production—An Updated Overview IPP PTS LPP PMC6158481__F4 WNT/Beta-catenin signalling APC GSK3B LRP5 LRP6 CTNNB1 PMC5384027__F1 Schematic of the DNA repair pathway FANCD2 RAD51 BRCA1 RNF168 RNF8 ATM RIF1 MDC1 PMC7893585__F9 Free CA125 promotes ovarian cancer cell migration and tumor metastasis by binding Mesothelin to reduce DKK1 expression and activate the SGK3/FOXO3 pathway MSLN DKK1 PMC4800296__F1 Simplified representation of the PI3K-AKT-mTOR pathway in pancreatic neuroendocrine tumours RHEB TSC2 RICTOR GRB10 TSC1 PTEN MTOR IRS1 PMC7894021__F6 Epidermal growth factor (EGF)‐mediated high‐mobility group protein A2 (HMGA2) transcription in hepatocellular carcinoma (HCC) cells EGF HMGA2 EGFR PMC6533250__F7 Wnt/Beta-catenin interacts with the FGF pathway to promote proliferation and regenerative cell proliferation in the zebrafish lateral line neuromast GSK3B FGF5C FGF10 CCND1 CTNNB1 PMC3969803__F3 Summary of the mechanism of several important drug candidates for anti-cancer metabolism therapies ACLY UCP2 UCP3 HEL-S-133P SCD HK2 FASN PMC5845388__F5 Germinal center pathway in systemic lupus erythematosus TH GC PC PMC3969803__F2 Summary of key changes in cancer metabolic reprogramming ACLY UCP2 BAX UCP3 HEL-S-133P SCD HK2 FASN ME1 HEL-S-26 PMC3167094__F1 New Hormonal Therapies for Castration Resistant Prostate Cancer HSD17B3 UGT2B15 HSD17B2 HSD17B10 AKR1C2 AKR1C1 STS PMC6487735__F1 Schematic representation of the linkage between SAMe, SAH, sarcosine metabolic pathway and methionine cycle HEL-S-182mP PIPOX PMC5009710__F6 Simplified model for extracellular phytohormones that regulate enzyme-encoding genes or TFs in phytohormone biosynthesis by signal transduction pathways TF MYB ERF MYC PMC3864579__F1 CD4 T-cell immunotherapy for chronic viral infections and cancer CD40 BCR APC IL4 PC CXCR5 PMC9170610__F3 Calcineurin in development and disease CDC42 TRPC6 ITGB3 RAC1 PMC9101307__F3 New Player in Depression: MiRNAs as Modulators of Altered Synaptic Plasticity WNT5B BDNF LEF1 SIRT1 CTNNB1 PMC8807567__F3 Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance FBXW7 WEE1 PMC8807567__F2 Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance GPX2 RBX1 KEAP1 IL1B PMC8807567__F1 Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance DBP PMC4624764__F8 Lentivirus Live Cell Array for Quantitative Assessment of Gene and Pathway Activation during Myogenic Differentiation of Mesenchymal Stem Cells KLF4 SMAD1 DKFZp781O1323 SP1 SMAD2 SMAD4 MYOCD ARHA NOX4 PITX2 TGFBR1 MRTFB MRTFA GATA6 PMC8589187__F1 Arginase Signalling as a Key Player in Chronic Wound Pathophysiology and Healing AMD1 ASL IGF1 PRL SRM SMO PMC8348955__F11 Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury FGF8A NR1C1 CYP7A1 FGF21 FGFR4 FGFR1 MTOR PMC4615225__F6 Overview of regulatory networks in which miRNA/target pairs function during the rice response to fungal elicitors AGO4 ERF AGO1 PMC3672663__F1 The canonical Hedgehog signalling pathway in mammals HHIP BOC SUFU SMO GAS1 PMC9620658__F1 Targets of aspirin in bladder cancer: bioinformatics analysis PCNA NFKBIA EDNRA CASP3 PTGS2 MYC CCND1 PMC4406394__F2 JAK2 Inhibitors: What’s the true therapeutic potential? EPO MTOR PMC6088189__F1 Tetraspanin roles during HIV-1 infection CD81 CD9 ADAM10 CXCR4 CD63 TSPAN7 PMC9045983__F6 Histone Methyltransferase SETDB1 Promotes Immune Evasion in Colorectal Cancer via FOSB-Mediated Downregulation of MicroRNA-22 through BATF3/PD-L1 Pathway FOSB BATF3 SETDB1 PMC7025498__F11 Celastrol-suppressed VM and angiogenesis in glioma EPHA2 MTOR VEGFA PMC2850885__F7 Proposed model of a EGFR/Beta-catenin/cyclin D1 signaling pathway in oral cancer HDAC1 EGF EGFR APC CCND1 CTNNB1 PMC4926181__F2 HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ MAP3K7IP1 RNF8 PMC8877852__F1 Characterization and Interaction Analysis of the Secondary Cell Wall Synthesis-Related Transcription Factor PmMYB7 in Pinus massoniana Lamb. CAD AMT PMC8675329__F3 Novel Insight Into the Fate of Cardiomyocytes in Ischemia-Reperfusion Injury: From Iron Metabolism to Ferroptosis TH SLC3A2 KEAP1 CHAC1 ARF4 SLC7A11 ATF4 EIF2A PMC11278107__F3 Antifibrotic activity of EchA in SSc model NOS2 CCL18 CD163 CD68 PMC2785475__F4 Expression-Based Network Biology Identifies Alteration in Key Regulatory Pathways of Type 2 Diabetes and Associated Risk/Complications BAD EGFR IL3 JAK3 PTPN1 IL4 DVL2 IRS1 ARAF FYN BCR FER NR3A2 EDN1 GRB2 SRC PMC8630233__F6 Intestinal microbiota and their metabolic contribution to type 2 diabetes and obesity TLR4 IRAK1 TRAF6 LBP IRAK4 MYD88 PMC2774576__F1 Diagram illustrating the biosynthetic pathway of n-3 and n-6 fatty acids from dietary precursors HEL-S-5 FADS2 FADS1 PMC6345611__F1 B-cell receptor (BCR) signaling pathways important to the pathophysiology and treatment options for chronic lymphocytic leukemia (CLL) SYK BTK BCR BLNK LYN GRB2 PMC8724284__F4 Wnt/Beta-catenin signalling: function, biological mechanisms, and therapeutic opportunities CRP ROR1 APC ROR2 GSK3B TNIK CTNNB1 PMC11625809__F3 LncRNAs are involved in the AR pathway to regulate enzalutamide resistance USP22 MDM2 HNRNPK PMC11625809__F2 LncRNAs are involved in the neuroendocrine secretion of prostate cancer STAT3 CBX2 CTNNB1 PMC11625809__F1 Neuroendocrine Evolution and drug resistance mechanism of prostate cancer PMC7472859__F8 The key proteins related to the PPI-PD network obtained as common proteins with the highest score through five ranking methods CDC42 TH PIK3CA FAS PTEN INS MAPK8 CXCL8 MAPK14 ALB HMOX1 TLR4 APP UBB HEL-S-44 MAPK1 UBC IL10 RPS27A SNCA MMP9 VEGFA IL6 RAC1 FGF2 HEL-S-162eP NFKB1 ADRB2 CASP3 ADAM10 BDNF PS1TP5BP1 AVP PMC10962462__F2 Novel molecular targets in endometrial cancer (EC) TF CDC2 ATR CGAS TSC1 CDK7 EGFR WEE1 ATM MYT1 MTOR CCNH PMC4279155__F1 The heme biosynthetic pathway and aspects of its regulation in hepatocytes HMBS HMOX1 ALAS1 MX1 FECH UROD PMC5830900__F1 Role of the TGFB family in mammary gland development and maturation HGF IGF1 MSX2 PMC3161159__F1 Retinoid metabolic pathway CYP26B1 CYP26C1 RARA ALDH1A3 RARB LRAT CYP26A1 PMC7920342__F8 Schematic drawing of the role of Lhx6 in regulating root furcation development DSPP WNT10A LHX6 AXIN2 PMC7776261__F6 Proposed model to illustrate the regulation of quiescence stage of persisting chronic myeloid leukemia (CML) leukemic stem cells by their microenvironment STAT3 BMP4 BMP2 PMC9605185__F3 Towards Precision Oncology: The Role of Smoothened and Its Variants in Cancer ADRBK1 EVC2 BCL10 SUFU SMO ARHA RAC1 PMC6287140__F4 Putative inhibitory pathway of Ac-ME in mediating the inflammatory response SYK TLR4 IL6 SRC IL1B MYD88 PMC2921612__F1 Molecular Diagnosis and Therapy of Kidney Cancer TGFA EGFR MTOR VHL PMC11954244__F2 Isoflavone biosynthetic pathway IPP ID2 PTS PPY PMC8106074__F1 Hepcidin pathway and the regulation of body iron homeostasis STAT3 BMP6 TFR2 BMP2 HAMP HFE JAK1 TMPRSS6 HFE2 PMC3465249__F3 Changes in hepatic gene expression in the KEGG PPAR signalling pathway in SNEB compared to MNEB cows LPL UBC UCP1 HEL-S-28 PLTP PMC4467136__F5 Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1 DTX1 NUMB HES1 HES5 PMC7965852__F2 LncRNA-mediated lineage transition CDH2 EGF CXCL12 REST HGF TGFA EZH2 IGF1R TUG1 HBEGF IGF1 BCL2 SERPINB2 PMC4640886__F1 Etomidate on the Steroidogenesis of Rat Immature Leydig Cells HSD17B3 STAR CYP17A1 SCARB1 CYP11A1 HSD3B1 LHCGR PMC7404231__F2 Stress-response mechanisms UBL5 ATF4 EIF2A PMC4619386__F6 DDVP profoundly affects energy metabolism HEL107 SDHA ACACB GOT2 FAS GSK3A GYS2 SUCLG2 PHKB LDHB SDHC PMC7197780__F1 Effect of ovarian stimulation on the expression of piRNA pathway proteins TDRD1 HIG-1 PNLDC1 MAEL PMC3157546__F7 The role of TAK1 signaling in bone metastasis MAP3K7IP1 COX2 MMP9 TNF PMC7531533__F1 Schematic showing how retinoids regulate thermogenic gene expression in adipocytes ADRB3 UCP1 PMC6985464__F3 Molecular signaling in poultry feather follicle and feather development APC GSK3B SMO CCND1 CTNNB1 PMC5209283__F7 Stat3 and C/EBPB synergize to induce miR-21 and miR-181b expression during sepsis STAT3 CCND1 CDK4 PMC8747952__F1 An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19) STAT3 ADAM17 SOCS3 PMC3575850__F8 Hypothetical model for functional redundancy of Rad18 and NHEJ in responding to oxidative DNA damage during G1 RAD18 PCNA SSB POLN PMC7977448__F2 Inflammasome activation NLRC4 NLRP1 NAIP NLRP3 AIM2 RHO IL1B PMC5419167__F7 Genomic and nongenomic cross talk of the GnRHR and GR signaling pathways on the GnRHR promoter in LBT2 cells JUN GNRHR GRIP1 PMC1782438__F2 Role of adaptors in T-cell signalling CDC42 VASP FYN LAT ITK GRB2 LCK PMC7738984__F8 Identification of the target genes and construction of its dynamic regulatory network SAA1 ADCY8 EGF GNG13 HEL-S-62p EGFR TACR1 HP HTR2A GNGT2 LCK PMC10030840__F2 Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases ERCC5 AGA NTHL1 FANCC PMC7298284__F1 Cyclin B1‐MAD1 interaction promotes checkpoint signaling at kinetochores CDC2 TPR KNL1 MCC NUF2 APC KNTC2 CCNB1 PMC7690154__F1 MiRNA biogenesis and regulatory signaling pathways RAN DGCR8 E2F4 SMAD2 SMAD4 PTEN ARHA DROSHA PMC9669513__F2 Effect of oncogenic activation of RAS signaling in OC STAT3 EGFR GRB2 MTOR PMC7935792__F2 Antigen presentation process CD40 CD80 PMC7823159__F7 Drosophila Activin signaling promotes muscle growth through InR/TORC1-dependent and -independent processes RHEB TSC2 RICTOR TSC1 SMAD2 PMC6593070__F7 Curcumin mediated inhibition of cell growth via inhibition of AKT signaling and activation of mitochondrial apoptotic pathway BAX PAF1 HEL-S-62p FOXO1 C9 BCL2 PTEN PMC6031772__F1 Arsenic Trioxide and Thalidomide on Angiogenesis and VEGF in Leukemia PTEN MTOR PMC8824753__F2 Oral-Intestinal Microbiota in Colorectal Cancer: Inflammation and Immunosuppression PANX1 TIGIT CEACAM1 NLRP3 IL13 TLR4 AIM2 S100A9 IL1B MYD88 PMC6317254__F2 Graphene oxide down-regulates genes of the oxidative phosphorylation complexes in a glioblastoma NDUFB2 UCP3 SURF1 NDUFB9 UCP1 NDUFS8 NDUFA10 NDUFS4 UCP2 COX2 ND6 NDUFB4 COX3 NDUFB7 ND3 SLC25A27 ND2 ND1 ND4 SDHD SDHA NDUFB10 SDHB CYB SDHC PMC11609686__F1 Illustration shows the suggested role of SARS-CoV-2 in EMT induced by ROS in cancer cells AXL NLRP3 NRP1 MTOR ACE2 PMC12104694__F1 Indole‐3‐acetic acid (IAA)‐mediated signaling pathways in epithelial and endothelial cells TEC EPHB2 PAPSS2 USP40 TLR4 MUC2 AHR CTNNB1 MYD88 PMC10100231__F7 Hypertrophic and fibrotic human PKD hearts are associated with macrophage infiltration and abnormal TGFB1 signaling TGFB1 SMAD2 SMAD4 CTNNB1 PMC7605689__F2 netboxr: Automated discovery of biological process modules by network analysis in R PIK3CA CCT6A AGAP2 HEL-S-77 PIK3R1 MPDZ RB1 IFNG CDKN2A PIK3C2B SNRPE A2M CNTN2 KDR MDM2 TBP FRS2 IFNA2 DOCK1 CRK IFNAR1 STAC3 IFNW1 EGFR LYZ PTEN CDKN2B HEL-S-100n MDM4 NCAM1 HLA-DRA CDKN2C CCND2 EPHA3 SNAPC3 IFNA1 FGF23 CDK4 NUP107 PIM1 KLF6 KIT PTPN11 SPRY2 TAF1 NR1C1 CBL AVIL ERBB2 PTPRE SH3GL2 PTPRB IFNB1 PMC4146704__F6 MIF-CD74-Lyn signaling cascade during osteoclastogenesis CD44 SYK CD74 NFATC1 LYN MIF GAB2 PMC7662069__F8 MiR-497-5p regulating osteo/odontogenic differentiation of SCAP SMAD2 SMAD4 SMURF2 PMC7147366__F3 Key metabolic pathways (glutathione metabolic pathway) involved in the interaction between GNPs and HDFs and the key metabolites involved LAP3 PMC3426490__F2 Flow chart showing the genes involved in TLR signaling pathway CD40 TLR3 TIRAP CD14 GLA IL6 FADD PMC8915851__F1 Of NRF2 Pathway in Preventing Developmental and Reproductive Toxicity of Fine Particles KEAP1 NQO1 MAF PMC6723309__F1 Adenovirus-directed innate immunity through nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) CGAS CXCR1 TLR4 EGFR IRF3 IL8RB TNF PMC8200290__F4 Up-regulated genes in advanced basal cell carcinoma overlaid on the KEGG “extracellular matrix–receptor interactions” pathway CD44 VWF CD36 CHAD CD47 PMC9485571__F1 Uncovering incontinentia pigmenti: From DNA sequence to pathophysiology RELA IL1A IL1B IKBKG PMC8200290__F1 Up-regulated genes in basal cell carcinoma compared with normal skin, overlaid on the KEGG “Pathways in Cancer” pathway APC MAL CRKL KL PMC5436295__F3 MAPK signaling pathway TES MAX ECSIT EGF FAS RAF1 EGFR INA TNF TRAF6 MEF2C NGF MOS NF1 NLK BDNF TRAF2 PMC4364530__F1 MITOCHONDRIAL DISEASES PART I: MOUSE MODELS OF OXPHOS DEFICIENCIES CAUSED BY DEFECTS ON RESPIRATORY COMPLEX SUBUNITS OR ASSEMBLY FACTORS SDHD COX1 COX10 SURF1 UQCRFS1 ND6 NDUFS6 COQ9 SCO2 COX17 NDUFA5 NDUFS4 PMC5985952__F7 Sequential activation of polyadenylation during oocyte maturation in Xenopus PGC MOS MYT1 PUM2 EIF4E PMC8040310__F8 The proposed molecular mechanism highlighting the role of betulinic acid in the pathophysiology of SCI and subsequent neurological recovery NLRP3 TFEB IL18 MTOR IL1B PMC8965895__F2 Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways DKK1 LRP6 CTNNB1 PMC7734336__F7 Elements of the SPINK1 pathway are involved in PDAC progression TGFBI SMAD2 TMPRSS15 PRSS2 PMC6723309__F2 Hypothetical model for adenoviral regulation of stress-induced EGFR signaling through NFKB RILP EGFR TSG101 PIN1 PMC8440965__F5 Acute Impacts of Different Types of Exercise on Circulating Alpha-Klotho Protein Levels IGF1 AK1 IGF1R MTOR PMC6436826__F1 Molecular Mechanisms of Regulation of Sphingosine Kinase 1 CERK tmp_locus_29 LPP PMC3650130__F85 Recently, Zhang et al ALK ATM PMC5515628__F1 AD immunopathology and mechanisms of action of targeted therapies OSMR IL4 IL31 PMC6721560__F4 The PI3K/Akt/mTOR signaling pathway RHEB MLST8 TSC2 RICTOR TSC1 GSK3B SESN3 PTEN RHO MTOR DEPTOR EIF4E PMC3606104__F3 Identification of genetic networks that regulate the induction of filamentous growth SWI5 CDC20 TPK1 FAR1 GLO1 CDC27 MCM2 ORC3 PMC7909315__F4 F-actin correlation pathway diagram DNAJA4 ROCK1 RHO RAC1 PMC4382258__F2 Essential role for autophagy in life span extension TSC2 TSC1 ULK1 TFEB PMC8093429__F1 Cellular Responses to the Efferocytosis of Apoptotic Cells RAB17 ATG5 PMC8200538__F3 Comparative Transcriptomics of IBD Patients Indicates Induction of Type 2 Immunity Irrespective of the Disease Ideotype CXCL12 CCL22 LCP2 CCL3 CNOT8 JUNB HERC3 IL33 IL1RL1 CCL5 TBX21 GATA3 TMED1 PLCG1 NR2F2 GCLC DPP4 MAF CCR4 ITK REPIN1 ZNF335 ARG2 CCL17 PMC3542205__F5 Illustration of the expression levels of enzymes within the glycolytic pathway and major connections in the C PGM3 HEL-S-68p PGM2 HEL-S-162eP PDC PMC5499884__F10 Molecular indices of viral disease development in wild migrating salmon EGF TGFB1 MAVS EGFR IL27 IFIH1 TLR9 MTOR MAPK8 CCL2 MAPK14 IFNG RNF125 F2 TLR4 USP18 IL2 MX1 TLR7 SRC EIF2AK2 STAT2 PSMB8 IRF9 PLAUR IL4 IRF1 IRF7 IL17A VEGFA XAF1 FOS FGF2 TLR3 ERBB2 HERC6 MAP2K1 CD68 PMC11278853__F2 Emerging evidence regarding the anti-cancer features of novel lipid-lowering treatments, including CETP inhibitors, bempedoic acid, and PCSK9 inhibitors ACLY PCSK9 BAX CCND1 AXIN2 PMC11278853__F1 Schematic illustration depicting the potential anti-inflammatory effects of hypolipidemic agents primarily targeting LDL-C reduction ACLY PCSK9 NLRP3 HMGCR VCAM1 VEGFA PMC10472888__F3 GPX4 in cell death, autophagy, and disease GPX4 GCLC SLC7A11 HEL-S-64p PMC8201009__F1 Cancer-Associated Glycosphingolipids as Tumor Markers and Targets for Cancer Immunotherapy CAS1 GAL FUT1 FUT2 PMC5415836__F2 Following TLR2-ligand interaction a signaling pathway is started using MYD88 as an adaptor molecule MAP3K7IP1 IRAK1 IRAK2 TRAF6 IRAK4 MYD88 PMC5703693__F3 Molecular mechanisms of the attenuation of PI3K and Akt, and the dysregulation of PI3K/Akt signaling pathway by gingipains BAD SP110 MTOR PMC11683146__F6 Tyr-Pro-induced Aß signaling pathway in SAMP8 mice IDE BACE1 APP PMC8262334__F2 Gastric Cancer Stem Cells: A Glimpse on Metabolic Reprogramming PKD1 SALL4 ENO1 HIF1A PMC8945445__F2 Links between Insulin Resistance and Periodontal Bacteria: Insights on Molecular Players and Therapeutic Potential of Polyphenols IL18 TRAF6 IRS1 MYD88 PMC7915224__F5 RAS regulation by posttranslational modifications HRAS RIN1 GSK3B SMURF2 SRC KRAS CTNNB1 PMC3124472__F4 Proteomic Analysis of Pathways Involved in Estrogen-Induced Growth and Apoptosis of Breast Cancer Cells RAP1GAP CDC2 BAD TLE3 RAP1A FZD7 CALM1 SRC TYK2 CTNNB1 RUNX3 PMC4659505__F12 Complexity of the direct and indirect effects of mTOR on signaling pathways MLST8 TSC2 RICTOR TSC1 MTOR DEPTOR PMC11557563__F2 Glycolysis and its ancillary pathways in WB muscle HEL-S-133P PHGDH LDHB PMC4581244__F1 Alterations of the KP in EAE and MS IFNG KMO PMC2603471__F1 Ageing, oxidative stress and cancer: paradigms in parallax PLN TNC GAL TGFB1 CXCL13 LAMC2 PEG3 AREG MMP9 TNF PTHLH IGFBP5 ABCC3 BCL2 DKFZp686P11128 PTGES LCN2 CXCR4 TNFSF10 PMC2495063__F3 Germline Mutations and Variants in the Succinate Dehydrogenase Genes in Cowden and Cowden-like Syndromes TSC2 PTEN HIF1A MTOR PMC5124559__F7 Schematic representation of the peptide generation pathway CFI BRCA1 CPN1 EP300 CUBN HNF1A CTNNB1 PMC7216262__F3 mTOR Signaling at the Crossroad between Metazoan Regeneration and Human Diseases CNTF EGF IGF1 PTEN MTOR PMC3807004__F2 Mitochondrial biogenesis by HLA20 involves activation of the Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1 Alpha (PGC-1A) pathway TFAM POC1A PMC4716629__F1 NFKB/p65 ubiquitination and degradation signaling RHD ING4 PDLIM2 COMMD1 PMC4727420__F2 Global view of biological processes and molecular functions of HDL proteins APOC2 SAA1 APOC1 APOD SELL HEL-S-62p APC APOE IHH VTN RBP4 B2M LY6E APOA2 AHSG APOA4 PON1 APOC4 PLTP GPLD1 SAA4 C4B_2 PMC3970295__F4 Wnt signaling as a pathway to increase bone formation FRAT1 SOST APC LRP5 LRP6 CTNNB1 PMC3527976__F2 Two rapamycin-sensitive myogenic mTOR signaling pathways MTOR IRS1 PMC6970510__F2 Different regulation of PAQR3 on multiple signaling pathways.Notes: Reproduced from Zhao Z, Chen Y DDB2 BTRC PAQR3 ATG14 TWIST1 PMC8222785__F1 Key Pathway to Cancer Resilience: The Role of Autophagy in Glioblastomas PNN EGFR PTEN MTOR HEL-S-26 MGMT PMC2888472__F2 Simplified scheme of signaling pathways required for maintenance of pluripotency of mESC (top panel) and hESC (bottom panel) STAT3 SMAD1 DKFZp781O1323 SMAD2 LIF PMC7406421__F2 Mechanism of human CoVID-19 infection: 1: infected animals can infect Humans followed by human-to-human transmission through aerial droplets and contact CRP IL33 IL6 CCL2 ACE2 PMC4981676__F1 Overall organization of JNK signaling pathways CDC42 MAP3K7IP1 RIPK2 RAC1 PMC9092395__AF1 LncRNA CBR3-AS1 promotes osteosarcoma progression through the network of miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway DDX54 MTOR PMC8529555__F6 Network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease ACLY TM6SF2 MSMO1 EBP SC5D DHCR24 AACS FADS2 ACACA YY1 FADS1 HSD17B12 HDAC3 ACSS2 WT1 CYP7A1 NPC1L1 LDLR ATF4 IDI1 FDPS GCK TM7SF2 PKLR CREB1 NR1i1 CYP51A1 SCD SQLE FASN SREBF2 ME1 MVK GPAM NR2A1 PNPLA3 ALDOB HMGCR ACAT2 DDIT3 MVD KLF5 DHCR7 FDFT1 NFYC ELOVL6 KLF13 PMC5711019__F9 Hyperthyroidism, but not hypertension, impairs PITX2 expression leading to Wnt-microRNA-ion channel remodeling ZFHX3 KCNN3 INA ENPEP PITX2 ZHX3 PMC3515033__F5 Cytokine intracellular signaling pathways IFNG STAT1 IL1R1 TRADD TRAF2 IL1B FADD MYD88 PMC3515033__F4 Neural and humoral activation of the brain by the periphery NTS CP PMC3515033__F3 Classification of nucleotide-binding oligomerization domain proteins (Nods) NOD2 NOD1 TNF IL1B PMC4648866__F1 Glycerol biosynthesis in respond to osmotic stress and redox statue and the interrelationship with yeast-derived aroma compounds in S GPD2 HEL-S-49 GPD1 PMC3515033__F2 Classification of Toll-like receptors (TLRs) IFNG TLR1 TLR3 TLR4 MAL TLR9 TLR8 TLR5 TLR7 TNF MYD88 PMC12004807__F6 Distribution of genes in the TNF signaling pathway IL15 ITCH C2 MLKL LIF CXCL10 CYLD FADD PMC10814963__F4 Proposed model for Fyn-CD133 signaling to the PI3K pathway induces melanoma intrinsic and acquired resistance to anti-cancer agent in melanoma cells GRB7 FYN BRAF PTEN MDM2 GRB2 PMC10814963__F2 Common mechanisms of melanoma progression and treatment resistance EGFR BRAF NRAS PMC11519383__F7 Schematic summary of the study THBS1 TGFB1 RUNX1 PMC8870128__F2 Antiplatelet Agents Affecting GPCR Signaling Implicated in Tumor Metastasis GPR31 PMC3432767__F1 Rac and RhoA signaling pathways during cytokinesis VAV3 PAK1 ECT2 ARHGEF7 ARHA RHO RAC1 PMC8638120__F3 Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases NAPA CACNA1A ATP6V1G1 ATP6V0A2 STX18 CLTA STX2 AP2A2 DNM3 CLTB CLTC PMC5852601__F1 Relationship between epithelial-to-mesenchymal transition (EMT) and the Wnt pathway in glioblastoma-derived stem cells (GSCs) ROR1 FZD5 APC GSK3B LRP5 LRP6 PMC11731108__F2 T cell senescence‐related signaling pathways ZAP70 STAT3 STAT1 CGAS MAP3K7IP1 ATM TERT TNF LCK PMC8150330__F1 Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics AAK1 TMPRSS2 NRP1 FURIN ACE2 PMC3894710__F2 Autophagy: A Crucial Moderator of Redox Balance, Inflammation, and Apoptosis in Lung Disease ULK1 ATG14 MTOR PMC7794713__F2 Net cholesterol flow through the body HMGCR ACAT2 LDLR ABCA1 ABCC2 PMC1768457__F1 CD14/toll-like receptor 4 (TLR4) intracellular signalling complex TLR4 CD14 TRAF6 LBP MYD88 PMC7982659__F3 Ingenuity Pathway Analysis (IPA) CEBPE HBEGF CEBPA EREG TGFB1 CSF1 TRIM24 MAP2K5 MAP2K1 AREG CSF3 PMC9297058__F1 Brain Abnormalities in PIK3CA-Related Overgrowth Spectrum: Physician, Patient, and Caregiver Experiences CDC42 PTEN MTOR RAC1 PMC1636619__F8 Oncogene cooperation in malignant rasV12, scrib−/− tumors SCRIB FOS PMC12240100__F6 Hippo-YAP signaling pathwayOverview of the Hippo-YAP signaling pathway, including the interactions between MST1/2, LATS1/2, YAP/TAZ, and TEAD LATS1 MOB1A MOBKL1A LATS2 PMC12240100__F5 PI3K/Akt signaling pathwayThe PI3K/Akt signaling pathway regulates cell growth, survival, metabolism, and angiogenesis RHEB TSC2 TSC1 EGFR MDM2 PMC12240100__F3 Hedgehog (Hh) signaling pathwayThe Hedgehog (Hh) signaling pathway regulates embryogenesis, cell proliferation, and tissue repair KIF7 SUFU GSK3B DYRK1B SHH SMO GLI3 PMC12240100__F2 Canonical Wnt/Beta-catenin signaling pathwayCanonical Wnt/Beta-catenin signaling pathway: the Wnt/Beta-catenin pathway regulates cell proliferation, differentiation, and survival CD44 EGF TCF3 APC LRP5 LRP6 CCND1 CTNNB1 PMC4287430__F1 Predicted model of the S LPA RPE PYGL FH OMP OGDH LAT PSD DCT CS PMC8247027__F1 Pathogenic postzygotic mosaicism in the tyrosine receptor kinase pathway: potential unidentified human disease hidden away in a few cells HRAS GRB2 MTOR KRAS PMC5998742__F1 Toll-like receptor (TLR) 4 signaling pathway TLR4 IRAK1 IRF3 TRAF3 TRAF6 IRAK4 MYD88 PMC3815682__F1 Comparison of typical mammalian cell citrate metabolism and the metabolic pathway for net citrate production MAL CS CIT PMC11932283__F6 Cerebral CYP enzymes in major exogenous substance metabolism—opioid biotransformation CYP2C8 CYP3A4 PMC8438590__F1 Antibody dependent enhancement: Unavoidable problems in vaccine development STAT3 SYK TBK1 IL10 IRF9 GSK3B TANK IRF3 IRF7 TRAF3 MYD88 ATG12 TLR3 ATG5 PMC11829548__F2 Toll-like receptor signaling pathways TIRAP TAB3 TLR9 IRAK1 TLR5 IRF3 IRAK2 IRF7 TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 PMC7286274__F3 Putative signaling effect of ⋅NO on nodule development ABI3 PMC6209660__F6 Potential mechanism of sodium butyrate on STZ-induced type 1 diabetes HMGB1 IL1B PMC11961548__F7 Construction of miRNA-gene regulatory networks in rat fatty liver associated PNF cases BRD4 TAF13 EIF3L TAF4 PMC12220693__F1 Normal tryptophan synthesis pathway HEL-S-90n KYNU KMO AANAT ASMT AFMID PMC9548536__F3 Biomarker-driven feedback control of synthetic biology systems for next-generation personalized medicine STAT3 IL10 IF2B1 IL13 IL4 IL6 ARHA IL6R IL10RB PMC3246665__F6 Diagram of signalling pathways indicating the possible mechanism by which sildenafil reverses the memory deficits in aged transgenic Tg2576 mice CDK5 ARC BDNF PMC11672511__F5 TNFR1-mediated survival and cell death pathways RIPK3 TBK1 FAS ZBP1 TRADD MLKL RIPK1 TNF OPTN CYLD FADD PMC11672511__F4 NLRP3 inflammasome induction by mtROS NLRP3 IRF1 CMPK2 TNF PMC8657754__F7 Lysine Acetylation in the Proteome of Renal Tubular Epithelial Cells in Diabetic Nephropathy BAX CASP9 THBS1 CASP8 CASP3 ATM PARP2 PMC3871884__F8 Schematic diagram illustrating central role for ROS and Src in hypoxia-induced pY654-Beta-catenin/HIF1A formation and tumor EMT TGFB1 EGFR HIF1A SRC CTNNB1 PMC11361850__F3 Mechanism by which mesenchymal stem cells-derived exosomes (MSCs-Exos) regulate the immune response NLRP3 TLR4 IRAK1 PTEN TRAF6 ERN1 MYD88 PMC9324584__F2 Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma PDGFD VEGFC THBS1 THBS2 IL6 VEGFA PMC11361850__F6 Mechanism by which mesenchymal stem cells-derived exosomes (MSCs-Exos) promotes axonal growth and neuronal regeneration NGF CBL HMGA2 NLRP3 SMAD2 PMC11361850__F5 Mechanism by which mesenchymal stem cells-derived exosomes (MSCs-Exos) regulates apoptosis and autophagy BAX BRD4 HDAC5 MAPK10 PTEN MTOR TRAF6 FGF2 PMC11672511__F1 Activation of the cGAS–STING signaling pathway by cytosolic mtDNA TBK1 CGAS IRF3 PMC5118094__F7 Cocaine regulation of specific Canonical Pathways at the mRNA level (left) and protein level (right) CDC42 ARPC4 ARPC2 ARPC5 NFATC1 RHO MYC DOCK1 ARPC1B EIF4E HEL-68 CRK GRB2 SRC HEL-S-15 PMC2923753__F2 Signalling pathways that regulate Candida albicansCHS gene expression MID1 PMC11907960__F2 Key effector cells in radiation-induced lung injury SMAD2 ARHA MTOR PMC11015576__F8 PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer TBK1 HMGB1 CGAS IRF3 PREX2 PMC11688492__F2 The molecular mechanisms related to SARS-CoV-2 and S protein effect on vascular dysfunction and BBB disruption ADAM17 ACE2 IL1B PMC11688492__F4 The molecular mechanisms related to astrocytes activation by the SARS-CoV-2 and S protein DPP4 NRP1 MMP9 PMC9010946__F9 Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification TH tmp_locus_29 LAT KIT PMC11688492__F3 The molecular mechanisms related to microglia activation by the SARS-CoV-2 and S protein PANX1 ADAM17 NLRP3 TLR4 IL18 IL1B MYD88 PMC8310117__F2 SARS-CoV-2/Receptor Axis in Heart and Blood Vessels: A Crisp Update on COVID-19 Disease with Cardiovascular Complications TF TMPRSS2 VWF IL16 IL1B PMC4073990__F4 Schematic description of the signaling pathways known to be activated by CCK1R and CCK2R STAT3 CRK HBEGF EGFR RHO GRB2 MTOR SRC IRS1 PMC9354016__F2 The mucin-like glycoprotein FCGBP in mucosal immunity and cancer MUC2 IL4 FCGBP TFF3 PMC5118094__F3 Environmental enrichment regulation of specific Canonical Pathways at the mRNA level (left) and protein level (right) GNG5 ADRA1A ADRA1D GNG12 CHRM3 HTR2A HTR2B GNB1 BTK ADRA1B AVPR1B TBP HRH1 GNB3 GNG10 AVPR1A GNB2 GNB5 AGTR1 GNG3 GNA15 GNG2 GNA14 GNB4 GNA11 CSK GRB2 GNG11 GNG7 PMC1851929__F8 Proposed model for the activation of oligodendrocyte apoptosis by MHV infection BAX FAS BCL2 FADD PMC6138873__F1 A model depicting cryptochrome signal transduction mechanisms in Arabidopsis RFWD2 CRY2 CRY1 PMC9092267__F8 De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway DVL3 CSNK2B CTNNB1 PMC6215617__F1 WNK pathway and major cancer-associated signaling pathways SGK1 SMAD2 OSR1 PMC7714562__F3 Overall depiction of the TRAF6-mediated signaling pathways TAB3 TLR9 IRF7 TRAF3 TRAF6 IRAK4 MYD88 CBL MAP3K7IP1 TLR3 TLR4 TLR8 TLR7 SRC PMC4723140__F2 Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone ECHS1 FASN HEL-S-5 ACACA PMC4723140__F1 Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone HEL-S-133P PKN2 HEL-S-32 HEL-S-30 MPC2 PMC12152351__F6 miR-1236-3p targets Toll-like receptor 4 to suppress the anti-Mycobacterium tuberculosis activity of macrophage TLR4 IL18 IL6 TRAF6 TNF MYD88 PMC3277127__F5 Curation of phosphoproteomic profiling and bioinformatics delineates distinct tyrosine kinase signaling pathways in an oncogene-specific manner STAT3 EPHA2 PXN EGFR PTPN1 CTNND1 PTK2B ERG KRAS HEL114 PLCG1 LYN GRB2 SRC PMC3061960__F5 NFKB activation in B cells BCL10 BCR TLR4 CARD11 RELA IRAK1 IRAK4 PMC9114699__F1 Thyroid Cancer and COVID-19: Prospects for Therapeutic Approaches and Drug Development BRAF MTOR RET PMC8744686__F4 Neurovascular Impairment and Therapeutic Strategies in Diabetic Retinopathy ATF4 RAC1 PMC8902753__F2 Gut Microbiota in Inflammatory Bowel Disease STAT3 NLRX1 NLRP6 NLRP3 COIL NOD2 FOXP3 SIRT1 PMC3524085__F7 Ingenuity pathway analysis of the 10-edge pattern subgraph showing cancer-associated interactions among its nodes RBM8 NCOR2 STAT3 RELA CREBBP NCOA1 NR3C1 PMC8491225__F2 Biological role of metabolic reprogramming in pancreatic cancer GLUD1 GOT2 HEL-S-32 ME1 PMC4723140__F3 Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone HMGCS1 HMGCR SQLE SC5D PMVK MVD DHCR7 FDPS IDI1 FDFT1 MVK PMC8491225__F1 Biological role of metabolic reprogramming in pancreatic cancer HEL-S-133P HK2 GFPT1 PMC7749645__F1 Convergent type I interferon and proinflammatory cytokine pathways shared between SLE and COVID-19 TBK1 STAT1 STAT2 IRAK1 IRF1 IRF3 IRAK2 IRF7 TLR7 TRAF3 TRAF6 MYD88 PMC3442981__F1 Metabolic pathways for 2,3-butanediol biosynthesis and pyruvate metabolism in S GPD2 BDH1 GPD1 PMC5607433__F5 Cytokine-cytokine receptor interaction NPS LTA FAS HGF LEP LTBR OSM SP1 LEPR CXCL2 VEGFA IL6 TNF TSLP PRL IF2D TPO IL6ST AMHR2 KDR EDAR TNLG7C IL23A IL9 PMC6388767__F1 Bromouridine sequencing (Bru-seq) of MI-503 treated Ewing sarcoma cells identifies the SSP as a key oncogenic target MTHFD2 PHGDH PSAT1 HEL-S-51e PSPH PMC4685484__F6 HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction HMGB1 TIRAP IRAK4 MYD88 PMC5073880__F4 Diagram of pathways by which AGEs affect genes involved in steroid synthesis and follicular development SMAD1 STAR DKFZp781O1323 CYP17A1 PMC4685484__F5 HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction IFNG HMGB1 TIRAP TLR4 IRF3 IRAK4 MYD88 PMC8662989__F1 Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction KHK ALDOB MPC1 GCK MPC2 PMC7805053__F4 Schematic diagram depicting IL17RD (Sef) modulation of the TIR signaling pathway TLR4 MAL IRF3 TRAF6 MYD88 PMC7547786__F2 Signaling pathways of IL-17A, pathological effect, and potential drug targets IL17RC COX2 CXCL5 CXCL1 MMP3 MMP9 TRAF6 CXCL8 PMC7049061__F1 Bibliometric analysis flow chart of mTOR pathway in liver disease research TH OGT PMC5123862__F6 Polymerase exchange during TLS on the lagging strand PCNA POLN CPD PMC7547786__F1 Th-17 cell polarization from naïve CD4+ T cells and activation STAT3 APC IL17A IL23R RORA PMC11852866__F8 ITIH5-mediated fibroblast–macrophage crosstalk exacerbates cardiac remodelling after MI CD44 STAT3 ARG1 PMC3107984__F3 Genetic analysis of biological pathway data through genomic randomization OXCT1 HMGCL BDH1 BDH2 PMC9636403__F1 Identification of TCF1+ progenitor exhausted T cells in THRLBCL may predict a better response to PD-1/PD-L1 blockade PMCH CD3D CXCR3 ZAP70 C3AR1 CCR5 IFIT1 CCR2 IFIT2 CCL23 HLA-G CX3CR1 PDCD1LG2 ITK MX1 CCR1 CXCR6 CD2 IFITM2 CD8B1 IFITM1 CXCL16 IRF1 SET CCL13 ENG PRF1 CCL19 FPR2 HLA-B CD3G HLA-C CD8A HLA-A CD3E PMC5295629__F4 Interactions of NIK wild-type and mutants DDX50 ACSL3 SLC25A10 NOM1 TRAF3 NOL9 TRIM28 EMD NOP56 RPL10 PRPF19 SFXN4 PGAM5 SLC25A13 MRPS7 RPS19 HEL-S-84 SMC1A C1orf57 RPL19 GCS1 MCMBP SLC25A12 SLC25A11 DPM1 RPN1 HLA-B HLA-C HLA-A NCL CALU VEZF1 NFKB2 LAS1L HEL-S-310 SLC25A22 GLUD1 CTCF RPL17 SEC16A MSI1 AIFM1 RCN2 RPS6 FASN AKAP8 RHOT2 LBR NOP58 RBFOX2 SEC63 YME1L1 PFKP PRKDC MYBBP1A RPS12 CDC37 RPS9 TRAF2 MAGED2 PMC5295629__F1 Noncanonical NFKB signaling pathway LTB RELB TRAF3 TRAF2 PMC2908766__F2 PI3K dependent signal pathway BAD GSK3B MTOR PMC5295629__F2 Interaction network of the noncanonical NFKB signaling pathway ACSL3 DYRK1A RAB11FIP5 TRAF3 NUMA1 GOLGA3 FBXW7 TRIM28 EMD HSPD1 ETV6 FAR1 NOP56 RPL10 ZC3H18 HNRNPAB PRPF19 SFXN4 HOMER1 PGAM5 SNAP29 SLC25A13 USO1 TNF TROAP FNTA FBXO28 RPL19 RANBP2 SLC25A12 SLC25A11 TRAF5 MCM3 HLA-B HLA-C HLA-A DIABLO HTRA2 CALU TBK1 PTMS LAS1L HEL-S-310 HEL-S-97n GLUD1 RPL17 SEC16A FYCO1 SPAG5 RCN2 BIRC3 RGPD3 DCAF7 RPS6 ANKRD34B GOLIM4 KLHL22 USP9X KTN1 RHOT2 NOP58 FKBP5 PHGDH NFKB1 RELA CDC37 RPS9 BIRC2 REL TRAF2 PMC7407626__F4 Summary of intrinsic apoptotic pathway BAX PAF1 C2 PMC12075242__F3 ETBF promotes tumorigenesis by distinct mechanisms STAT3 TLR4 NFAT5 PHF5A METTL14 KAT2A PMC8227573__F1 An Insight into the microRNAs Associated with Arteriovenous and Cavernous Malformations of the Brain TIMP3 TIMP1 SPRED1 PTEN PMC7561614__F1 Metabolic pathway for squalene synthesis in oleaginous yeast IPP MAL MVD CIT PMC12075242__F5 Fn involved in immunotherapy CGAS TPK1 IRF3 PMC7349686__F2 Possible signaling mechanisms of ectopic osteogenesis in skeletal muscles SMAD1 MAP3K7IP1 DKFZp781O1323 TGFA SMAD2 HDAC5 SMAD4 RUNX2 ID1 CTNNB1 PMC7667972__F9 Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch DAGLA DDHD1 COCH GPR55 PMC3272823__F3 Involvement of the ERK pathway in the TGF-Beta-induced epithelial-mesenchymal transition EGR1 HGF SMAD2 SMAD4 GRB2 PMC8945730__F4 Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age ATG10 ATG3 ATG12 ULK1 RP2 ATG5 PMC7849461__F2 Renin-angiotensin-aldosterone system ACE2 IL1B PMC8040309__F3 FGL1-involved signaling pathways STAT3 FGL1 MTOR LAG3 PARP1 PMC5410324__F1 PI3K pathway mutations are associated with longer time to local progression after radioembolization of colorectal liver metastases PI3 EGFR BRAF PMC7710624__F7 Genetic and Physical Interaction Mapping Reveal New Facets of RAS Pathway Biology HRAS RALB RALA NRAS ARHA KRAS RADIL PMC2745891__F6 Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mTOR activity and p27Kip1 localization TSC2 TSC1 GSK3B SHH SMO MTOR PMC2781394__F8 HGF-mediated inhibition of gluconeogenesis in primary hepatocytes HGF NR2A1 USF1 PMC6695538__F1 The crosstalk between estrogen receptor and growth factor receptor intracellular signaling pathways MTOR CCND1 CDK4 PMC4065383__F2 Origins and removal of ribonucleotides in DNA DNA2 FEN1 PCNA INS PMC11201890__F2 USP5 participates in immune regulation through a variety of signaling pathways FOXM1 NLRP3 TRAF6 CTNNB1 PMC2838378__F2 Simplified schematic of the T cell receptor signaling pathway LAT ITK GRB2 LCK PMC10380517__F2 CDK4/6 Inhibitor Resistance in Hormone Receptor-Positive Metastatic Breast Cancer: Translational Research, Clinical Trials, and Future Directions CDK6 FGFR1 WEE1 MTOR CDK4 PMC2838378__F1 Simplified schematic of the IgE receptor (FcERI) signaling pathway SYK FYN LAT LYN GRB2 LAT2 PMC8269036__F2 mRNA-miRNA-lncRNA Regulatory Network in Nonalcoholic Fatty Liver Disease TEAD2 AMOTL2 SMAD4 FOXA2 NF2 YAP1 PMC11946680__F7 Action induced by 3-MCPD RIPK3 MLKL RIPK1 PMC5108628__F1 Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity TBK1 ADAR MAVS SMS USP18 IRF3 FADD PMC6911338__F7 Schematic diagram of miR-155 intercellular transport and activation of mTOR signaling pathway MTOR DEPTOR EIF4E PMC5524291__F9 An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation BCL2 IRF4 CCND1 BCL6 PMC3795364__F6 Schematic presentation of the influence of angiogenesis inhibitors on EC signaling CXCR3 MAP2 MTOR PF4 PMC11568081__F5 Figure illustrates the mechanism by which kaempferol enhances sensitivity to anti-digestive system tumor drugs STAT3 BAX PTBP1 EGFR PMC8584162__F2 Defining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer DLG2 ETV5 STAT3 ALK FRS2 JAK3 GRB2 SHE SRC IRS1 PMC11568081__F4 Figure shows how kaempferol suppresses metastasis and invasion while inducing autophagy in digestive system tumors CDC2 BAX ATG12 EGFR MTOR SRC ATG5 PMC11568081__F3 Figure illustrates how kaempferol inhibits digestive system tumors cell proliferation CDC2 BAX PTBP1 H2AX ATM CCNB1 KRAS PMC11568081__F2 Figure illustrates how kaempferol induces apoptosis in digestive system tumors CDC2 BAX CYP27B1 JUN BAD FAS NLRP3 GPR49 BIK PMC9465383__F1 Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy CD36 FASN USP11 TRIB1 LDLR MTOR PMC9329679__F1 Critical Appraisal of Filgotinib in the Treatment of Ulcerative Colitis: Current Evidence and Place in Therapy STAT2 IRF9 JAK1 TYK2 PMC2424235__F1 Auxin signaling RBX1 CAND1 PMC4935211__F1 Schematic diagram of TRAIL-induced apoptotic signaling cascades BAX FADD PMC5593678__F2 Autophagy in hepatocellular carcinoma: friend or foe RHEB EGFR PTEN ATF4 EIF2A GAPT PMC5768349__F4 Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics PPIC BSN KLF7 TGFBI WNT3A SNRK E2F7 GIP SLC7A11 CD133 TCF4 RARA SOX1 CGB3 CCND1 SOX4 DCN CDH2 CACNB1 NT5DC3 SIK1 EGR1 SOX11 TMSB15B ATOH7 ELAVL1 VPREB3 PLAG1 CACNB4 P2RX1 RET CP PMC5768349__F7 Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics CD40 RAB3IP FGD4 IL6 EFNA1 PID1 CELF2 SEMA3A PDK4 AJUBA ADAMTS12 CP UNK PMC5618569__F2 Schematic representation of the cytoplasmic and nuclear functions of the autophagy—related factors Beclin-1, LC3B and p62 RNF168 PML MTOR PMC3794382__F1 Gene sets are not pathways ECSIT FAS MAP3K7IP1 CD14 TRAF6 TNF TRAF2 SET PMC5618569__F1 Stages of autophagy ATG16L1 ULK1 PML ULK2 PMC2783241__F2 Kidney development: from ureteric bud formation to branching morphogenesis EGF HGF GDNF BMP4 GREM1 SPRY1 RET GATA3 PMC6335102__F8 ANG II induces cardiac hypertrophy by multiple means involving direct actions on cardiac myocytes (cm) or the release of paracrine factors from other cell types, such as endothelial cells and fibroblasts/myofibroblasts ATR ADAM17 EGFR TRPC4 TRPC1 NAMPT SIRPA ARHA MTOR SRC NOX4 PMC6335102__F7 ANG II signaling and vascular fibrosis HBEGF ADAM17 EGFR SMAD2 ARG1 PMC9464936__F3 Know when to fold ‘em: Polycomb complexes in oncogenic 3D genome regulation BCOR BCORL1 PRC1 BAP1 KIP75 PMC7439504__F6 Beyond the cell factory: Homeostatic regulation of and by the UPRER FOXO1 BCL2 TRAF2 PMC9284233__F2 Glycolysis in Innate Immune Cells Contributes to Autoimmunity CD40 STAT3 TBK1 CD80 HEL-S-133P HK2 HEL-S-162eP CCR7 ARG1 IRF4 CSF1R PMC8847744__F5 Intestinal Infection of Candida albicans: Preventing the Formation of Biofilm by C. albicans and Protecting the Intestinal Epithelial Barrier STAT3 BAX STAT1 BAD SOCS3 PMC5193387__F4 Harnessing cancer cell metabolism for theranostic applications using metabolic glycoengineering of sialic acid in breast cancer as a pioneering example OGT RENBP GNE EGFR GC COCH MUC1 NPL PMC6861177__F1 Mitochondrial quality control TFAM OPA1 NRF1 PMC10390316__F1 Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases ACVR1 EGFR IL6 ARHA CXCL10 CCL2 PMC12125403__F4 Posttranslational modification of NLRP3 inflammasome components via ubiquitination and deubiquitination STAMBP TRIM31 TET2 OTUD6A ZNF883 TNFAIP3 RNF31 SLC25A3 TRIM59 USP9X SKP2 INSIG1 HUWE1 TRIM62 USP14 USP30 TRIM50 TRIM24 NLRP3 METTL3 USP47 TRIM65 BRCC3 PMC12125403__F1 Transcriptional regulation of NLRP3 expression MAPK14 FYN NLRP3 CD36 NFAT5 AHR MTOR TNF ELF3 FADD PMC4528364__F8 Conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy ATG10 DCP2 ATG3 ATG14 PMC5925455__F7 Hypothetical model for the aggravation of autoimmune response in Pdmx-associated and spontaneous NT1.The immune response in NT1 is highly heterogenic with different pathways affected during the disease progression IFNG P2RY11 CTSH TNF PMC8424797__F2 LncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy BAX TET1 AKT3 RELA UHRF1 PMC8424797__F1 LncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy FOXO1 IRF9 PMC8424797__F3 LncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy TERT CMTM6 CMTM4 PMC3405855__F5 Models of apoptosis-induced proliferation in mammals EGR1 FOS FADD CP PMC7543933__F2 IFN-Alpha-driven pDC-B cells crosstalk leading to antibody production in response to viral infection CD40 PDC IFNA4 IRAK1 TLR7 IRAK4 IL1B MYD88 PMC6279409__F2 Sensing danger through a “finger” CNBP MYD88 PMC9697017__F6 Integrating Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Hydroxysafflor Yellow A in Delaying Liver Aging SVIP PLN SELL MAL CRTC2 ELF2 HEL-S-30 DAO POR GCG NR1C1 HRC F2 PI3 COIL MCU SKA1 GPT CIT PMC7404278__F1 Molecular switches regulating hair growth SHH SMO CTNNB1 PMC6921965__F1 DSB repair pathways in mammalian cells RAD52 RAD51 FEN1 BRCA1 POLE PMC2500163__F4 HIV Replication Enhances Production of Free Fatty Acids, Low Density Lipoproteins and Many Key Proteins Involved in Lipid Metabolism: A Proteomics Study RPS3A FAS VLDLR APOB RPL7 PMC8780133__F3 N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy GSK3B TRPC6 BDNF CRTC1 PMC8429596__F1 Translational Potential of RNA Derived From Extracellular Vesicles in Multiple Myeloma MIA STRC CXCL1 MSC FAP PMC9440251__F6 Nintedanib induces a senolytic effect in senescent HDFs via JAK2/STAT3 pathway STAT3 CDK2 PMC4045488__F1 MicroRNAs in pancreatic cancer metabolism CD36 FAT1 PMC8615627__F2 LncRNAs: Novel Biomarkers for Pancreatic Cancer FOXD1 STAT3 EGF RAF1 EGFR PTEN RHEB TSC2 TSC1 FOXO3A OTUD7B GRB2 JAK1 PMC8615627__F1 LncRNAs: Novel Biomarkers for Pancreatic Cancer TF SMAD1 DKFZp781O1323 LIMK1 SMAD2 SMAD4 NODAL RHO TRAF6 RUNX2 PMC8187363__F3 Involvement of accessory proteins in diseases ZAP70 BCR SHOC2 IQGAP1 FHL1 GRB2 SRC GAB2 LCK PMC8187363__F2 Involvement of RTK-RAS-MAPK accessory proteins in signal transduction LPA ZAP70 ERBIN CBL SPRED1 SHOC2 FRK NPM1 IQGAP1 FHL1 GRB2 PMC8102505__F1 Autophagy pathway ATG10 ATG3 ATG12 ULK1 WIPI2 SNAP29 UVRAG AMBRA1 ATG14 SQSTM1 STX17 TRAF6 PMC9582647__F1 Plasma membrane and brain dysfunction of the old: Do we age from our membranes? IL1R1 TLR4 GSK3B SOCS3 MTOR IRS1 IL1B PMC4377510__F5 Possible transforming pathway IGF2BP1 FAS FAF1 CTNNB1 PMC4801113__F2 Iron homeostasis in host defence and inflammation BMPR2 STAT3 BMP6 TFR2 SMAD4 HAMP HFE JAK1 TMPRSS6 HFE2 PMC2962793__F1 a, b Bioactive eicosanoids derived from the arachidonic acid cascade LOX COX1 COX2 PMC4404183__F2 Natural history of Beta-cell adaptation and failure in type 2 diabetes PRLR HGF PTEN IGF1R IRS1 CTNNB1 EIF4E RHEB TPH1 TSC2 FOXM1 TCF7L2 FOXD3 TSC1 NR2A1 IGF1 FOXO1 PRL TPH2 BCL6 PMC7222158__F3 Gene network of regulation of synaptic transmission, glutamatergic (obtained using Pathway Studio v SCN9A PTGS2 GRIK2 PMC1297571__F6 Simplified diagram of the proposed signalling events leading to Cyp7b gene transcription in synovial fibroblasts TRADD TNF TRAF2 FADD PMC2962793__F2 Cytochrome P450 epoxygenase expression in tumor cell compartments and their potential role in cell–cell communication in the tumor stroma CYP2J2 CYP2C9 CYP2C8 FGF2 PMC3619152__F10 Proposed pathway showing increased Nox4 expression and H2O2 levels in PPHN PA, leading to a decreased ecSOD activity and vasoconstriction, and increased NFKB and cyclin D1 leading to pulmonary vascular remodeling TH CCND1 NOX4 PMC7824059__F4 Top-ranked and interested pathways in Holstein and Jersey cows CAV3 CAV2 TNC TRADD PPIF TAB3 CXCL2 PTGS2 TNF TRAF6 FOS CXCL3 MAP3K7IP1 EDN1 NFKBIA P2RX1 IL1B PMC8228851__F1 Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases SOCS3 MTOR IL11RA PMC3734218__F1 Roles of Genetic Polymorphisms in the Folate Pathway in Childhood Acute Lymphoblastic Leukemia Evaluated by Bayesian Relevance and Effect Size Analysis HEL-S-22 DHFR SLCO1B1 MTRR TYMS SLC19A1 VIT MTHFD1 SHMT1 GGH MTR FPGS ABCB1 TPMT PMC5584184__F3 Postendocytic sorting of receptors along the endolysosomal pathway APPL1 PI3 RAB35 EEA1 PMC4002842__F2 Network analysis of expression profiles of 10 μmol/L AA in HK-2 cells F11R KLF2 LTA MPG LTBR GPX4 JAK3 PROCR UCP2 ALB TFRC PLAT LOX CD74 ETV6 EBI3 TPM3 SAA2 SPIB AMH OPTN SP1 TNFRSF9 LEPR CXCL2 IRF7 IRS1 PCK2 LTB NAIP TCF3 PRF1 SERPINE2 HEL-S-68p MTF1 HEL-S-69p HAS3 LCN2 CCL20 CD68 PMC4424395__F6 Signaling pathways associated with litter size in boars TF EQTN LYZA C3orf60 CELF1 IL4 INS NDUFAF4 MAPK3 MAPK14 MYLK HSPD1 GSTM3 HEL-S-49 HEL-S-162eP IL2 MDH2 RAB2A PMC7653868__F2 Yellow nodes represent genes enriched in Infiltrating Ductal carcinoma of breast identified by Pathway enrichment ACLY STAT3 NMT1 CDC6 GAS THBS2 HDAC3 ARHGAP26 BCL9 SLIT3 WWTR1 ALK SIAH2 ARHGEF12 INPP4B PBRM1 PCLAF SRI IGF2BP1 PFKFB4 RHOBTB1 S100A10 RNF11 AFF4 NGFR BAP1 HEL70 ARHA STRN EML4 CCDC6 SDHD RGS17 PLXNA3 PPP1R9B DAPK2 AKAP12 PMC7653868__F1 Reactome FI network SHC1 NMT1 SETD2 HDAC3 FYN ALK PBRM1 ETV4 MLF1 PCLAF EIF2AK2 IGF2BP1 PFKFB4 SP1 RHOBTB1 MAP4 RNF11 BAP1 HEL70 STRN HRAS SDHD NLRC4 TIAM1 BRCA1 Nbla10317 AKAP12 ACLY BIRC6 GAS CDC6 THBS2 LATS1 RARA SLIT3 PLCG1 LIMD1 SIAH2 ARHGEF12 FHL1 ANKHD1 DDX5 UBC JUN S100A10 NGFR YBX1 ARHA NCOA1 EML4 NR3C2 RGS17 DAPK2 EP300 PMC8988011__F7 Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions LATS1 LATS2 ANKRD1 PMC5632348__F6 Schematic illustration of the TLR4 signaling pathway (a) and inhibition via TAK-242 (b) TIRAP TLR4 IRF3 MYD88 PMC7653868__F3 Pathway in FI sub-network STAT3 SHC1 NGFR BAP1 HEL70 ARHA NCOA1 SETD2 HDAC3 NLRC4 LATS1 ARHGAP26 RARA WWTR1 LIMD1 SIAH2 BRCA1 ARHGEF12 ETV4 EIF2AK2 PMC7293352__F3 Inositol phosphate and phosphatidylinositol signaling pathways in metazoans INPP1 IMPA2 PI3 IPMK PTEN INS PMC3596735__F5 Mechanism of response to anti-EGFR inhibitors EGFR BRAF KRAS PMC3596735__F3 ERK/MEK pathway CDC42 BAD PRKCZ KRAS DOCK1 EIF4E ERBB3 RHEB CRK GRB7 FYN MOS GRB2 FCGR2A LCK PMC8359944__F1 Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat CAD HEL-S-133P EPO VEGFA HEL-S-87p ANGPT2 PMC4076992__F2 Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease ATF4 EIF2A XBP1 TRAF2 PMC12056223__F7 Schematic summary of the role of targeting Dnmt3a mediated ID2 promoter in MMT ID2 SMAD2 PMC10636769__F2 IORT regulates the proliferation of microRNA-223, thereby reducing EGF levels and ultimately attenuating the EGFR signaling pathway EGF EGFR MTOR PMC4474537__F4 BMRF-MI: integrative identification of protein interaction network by modeling the gene dependency PRMT1 RAN GRINA SHC1 MAFG PXN SMAD2 PIK3R1 SMAD4 PTPRC EFNA1 FYN BCR EPOR PRKCA MAPK12 KDR SRC CRKL DLG4 BARD1 CCT7 TAF11 CDKN1B PSEN2 CSK MCM2 CXCR4 GDF9 CDC42 HEL113 BAD SETDB1 NCK2 PSMD2 KPNA2 STK35 YWHAQ YWHAG MYOD1 PTN EEF1G ARHA NCOA1 ERH TAF1 HEL-S-102 IGSF21 CDC37 UBE2I PS1TP5BP1 PMC6947309__F1 Stimulation of a particular TLR by DAMPs and activation of the IL-1 pathway via stimulation of IL-1R TRAF6 IRAK4 MYD88 PMC5668000__F6 Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer MAX PRKD1 MYC CTNNB1 PMC7800773__F1 Combination therapies for MPNSTs targeting RABL6A-RB1 signaling RB1 CDK6 CDK2 CDK4 PMC8954347__F1 LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection SYK BCL10 TLR4 TLR9 IRAK1 IRF3 TRAF6 IRAK4 IL1B CARD9 MYD88 PMC3734242__F8 Role of PTPA in the Destruction of Periodontal Connective Tissues TRADD PTPA SRC TRAF6 TRAF2 IL1B MYD88 PMC8630816__F3 MCP-1 targeting: Shutting off an engine for tumor development STAT3 TNLG1B GSK3B IL33 MTOR SRC TNF PMC3742868__F11 Proposed scheme for the role of mTOR in p53-induced kidney cell injury FAS PMC5417715__F2 Drosophila as a model for homeostatic, antibacterial, and antiviral mechanisms in the gut STAT3 MEA1 EGFR CDK9 PMC4324555__F5 CREB and the CRTC co-activators: sensors for hormonal and metabolic signals SIK2 CRTC2 TAF4 PMC5733538__F6 The positive feedback regulation between transglutaminase 2 (TGM2) and TLR4 signaling in hepatic stellate cells (HSCs) activation and liver fibrosis TLR4 CD14 IRAK1 IRF3 IL6 CCL5 CXCL10 IFNA1 IL1B MYD88 PMC5400276__F3 Chemical Reaction Network Theory elucidates sources of multistability in interferon signaling STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC8861086__F3 Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease IL33 IL36A PTEN MTOR MYD88 PMC8438545__F2 Evaluation of the molecular response of corpora lutea to manganese–amino acid complex supplementation in gilts EBP SQLE DHCR24 MVK HMGCR ACAT2 C2 PMVK MVD DHCR7 FDPS HSD17B7 TM7SF2 PMC8977492__F2 Adenosine-A2A Receptor Pathway in Cancer Immunotherapy IL10 HIF1A ADA PMC1397816__F2 Activation of canonical Wnt signalling pathway in the presence of Wnt signals APC LRP5 LRP6 CTNNB1 PMC1397816__F1 Inhibition of canonical Wnt signalling pathway in the absence of Wnt signals APC LRP5 LRP6 CTNNB1 PMC11686125__F5 Related target action relationship between QJ and the HIF-1 signaling pathway TF STAT3 RBX1 HEL-S-133P TLR4 HEL-S-162eP EPO ENO1 PFKL MTOR HEL-S-87p VHL PMC1397816__F5 Inhibition of Wnt signalling by a Fz-dependent pathway LRP5 LRP6 NLK PMC6737011__F9 Metabolism in WSSV-infected hemocytes showing the aerobic glycolysis, glutamine metabolism and lipogenesis pathways at the WSSV genome replication stage (12 hpi) GLS MAL CS HEL-S-26 CIT PMC4358823__F2 Human prostate cancer vaccines – proposed mechanisms of action and future combinatorial treatment strategies CD80 PMC4358823__F1 Human prostate cancer vaccines – proposed mechanisms of action and future combinatorial treatment strategies CD80 CD58 CD2 PMC4768650__F4 Interleukin-5 plays a fundamental role in the proliferation, maturation in the bone marrow, recruitment and activation at sites of allergic inflammation of eosinophils EPX MBP IL5RA LYN PMC9697478__F13 Immunomodulatory Effects of an Aqueous Extract of Black Radish on Mouse Macrophages via the TLR2/4-Mediated Signaling Pathway STAT3 IL16 TLR4 PMC4768650__F3 Eosinophils modulate the functions of a multitude of cells of the innate and adaptive immune system EPX NGF MBP ELL CCL17 PMC4768650__F2 Eosinophils contain and/or release a wide array of preformed and de novo synthesized mediators important for their effector functions TF CXCL9 CCL3 CXCL5 CXCL1 VEGFA CCL2 CXCL8 CCL23 EPX CXCL11 IFNG VEGFB IL16 MBP IL1B CCL17 PMC3667593__F5 Abbreviated Pluripotent Cell Cycle CDC2 CDK6 SP1 IRF2 CDK2 HINFP ATF1 YY1 CDK4 PMC9235300__F2 Telocytes in Fibrosis Diseases: From Current Findings to Future Clinical Perspectives BAX CERK HGF SMAD2 APC SMAD4 MTOR RSPO3 RUNX2 TGFBR1 CTNNB1 CDIP1 GPR49 PMC7140616__F2 Activation of the canonical Wnt pathway in head and neck cancers is mediated by various factors CIP2A EGF EGFR GSK3B DPAGT1 CCND1 CTNNB1 PMC7222158__F2 Gene network of positive regulation of fat cell differentiation (obtained using Pathway Studio v INHBA PTGS2 RARRES2 PMC7140616__F1 Fates of Beta-catenin, when the canonical Wnt pathway is not activated APC GSK3B FAT1 WIF1 CTNNB1 PMC3404043__F3 Whole Transcriptome Analysis of the Effects of Type I Diabetes on Mouse Oocytes DBF4 PCNA LAT SMC3 SMAD4 INS SKP2 POR EN2 MON2 RAD21 CDK7 PI3 HEL-S-69p CDK2 MDM2 CIT PMC7072240__F6 Cooperative regulation of genes involved in glutathione (GSH) and NADPH synthesis by Nrf2 and ATF4 MTHFD2 GCLM CTH HEL-S-51e MTHFD1 PHGDH GCLC PSAT1 ATF4 ASNS HEL-S-64p PSPH HEL-75 PMC7523021__F2 Integration of networks of SFH targets PLN ZAP70 EGF BAD LAT CHRM1 EGFR SPHK1 GSK3B CHRM3 HTR2A PPP3CA ATP2A1 ADRA1B F2R KDR MDM2 NOS2 JUN CHRNA7 TNF IRS1 ICOS CHRM2 ADRB2 HEL-S-102 BCL2 GRB2 TRAF2 PMC10505605__F1 Extranodal lymphoma: pathogenesis, diagnosis and treatment CD79B CD79A FAS CARD11 IRAK1 PTEN MTOR MYC IRAK4 MYD88 BTK BCR BCL2 PMC5928506__F8 MSC PGE2 secretion reprograms M1 via two independent pathways to M2 macrophages GSK3A COX2 PMC3272847__F2 E6-mediated survival signaling EGFR MDM2 MTOR PMC7862665__F2 E3 ubiquitin ligases in the development and progression of glioblastoma STAT3 CIC KBTBD7 EGFR GSK3B PTEN TRAF6 CTNNB1 TRIM21 CBL FYN PHLPP1 TRIM24 TRIM9 NF1 PFKP TRIM11 GRB2 PMC4294344__F1 Bioinformatics analysis of the serine and glycine pathway in cancer cells GLDC PHGDH SHMT1 GLS2 HEL-S-30 PSPH PMC7734287__F8 Mechanism for Forkhead box Q1 (FOXQ1) induced angiogenesis and macrophage infiltration in colorectal cancer (CRC) tumorigenesis TEC EGF HBEGF ANGPTL4 ANGPT1 FOXQ1 PLAUR ANGPT2 CCL2 TWIST1 PMC4065761__F1 Current models of the signaling pathway of the spindle assembly checkpoint (SAC) MCC CDC20 APC PMC9608318__F2 Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-19 IFNAR2 IFIT1 IFNAR1 RSAD2 ISG15 PMC3717945__F3 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance RHEB TSC2 TSC1 NF1 ULK1 GSK3B PTEN GRB2 MTOR SHE DEPTOR IRS1 PMC4749963__F2 A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells SAT2 SMS SRM PMC4838361__F5 PARI regulates the repair of single-strand gaps left behind the replication fork HLTF FANCM FBXO18 PMC5249001__F3 Pathway Studio guided network that describes regulatory connections between the deregulation of Aurora kinases, caspase-3 and osteopontin-encoding SPP1 AURKA POU4F1 AURKB CASP3 IRX2 VEGFA INS SPP1 PMC10040566__F2 Th-17 cells and IL-17 in the metastatic spread of breast cancer: As a means of prognosis and therapeutic target IL17RC VEGFC MMP19 TRAF6 PMC7930745__F3 TMEM16A regulates cancer cell proliferation CDH2 SMAD2 SMAD4 ARHA PMC5559791__F4 This adipogenic gene network is centered on the up-regulated transcription factor CEBPA and interactions with several other transcription regulators (a) ASS1 KLF2 CD36 FACL4 KPNA2 ALB FBXW7 COL1A1 MRTO4 E2F4 DGAT2 MED27 LPL ACSF2 COL1A2 MYH10 LIMK1 OSTN FASN HSD11B1 FABP4 GBP1 DEPTOR ID3 CEBPA ACSL1 KPNA3 BCL2 KLF5 HLA-B KLF13 PMC5559791__F3 Interactions of two transcription factors (PPARG and PPARD) and their direct target genes that control lipid metabolism in abdominal fat of juvenile HG and LG chickens PPARG AEBP1 HEL113 VLDLR OXR1 THBS2 MGST1 NR1C2 MGLL PCK1 SLC27A1 MRTO4 DGAT2 SNX4 pcap LPL THBS1 RPSA FASN SLC22A3 PLG SLC2A3 FABP4 ATP6V0D1 TUBB PID1 CEBPA MYOM2 ACSL1 PDK4 TCEA3 ANGPTL3 BCL2 PMC7606919__F1 Resistance to immunotherapy ADAR TIGIT TGFA IDO1 POLI BTLA B2M LAG3 PMC1838573__F1 Mitochondrial pathway through Bcl-2 family members BAX BAD TRADD IL16 TRAF1 TNF TRAF2 FADD PMC6106745__F2 Viral carcinogenesis pathway and differentially expressed genes in primary NSCLC tumors CDC42 ACTN4 CCR5 CCR4 CCR3 ARHA CCR8 PMC5559791__F6 Ingenuity Pathway Analysis of RNA-Seq data showed that the canonical coagulation system was over-represented by up-regulated genes in abdominal fat of LG cockerels TFPI KL PMC9162453__F1 Heme biosynthetic pathway HMBS MLIP MAL CPO FECH ABCB10 UROD UROS PMC6409413__F7 miR-582-3p and miR-582-5p Suppress Prostate Cancer Metastasis to Bone by Repressing TGFB Signaling TBR1 THBS1 ADAM19 SMAD2 SMAD4 VEGFA NEDD9 TGFBR1 PMC7898953__F1 Extra-cellular and intra-cellular signalling regulating cardiomyocyte proliferation and cardiac regeneration LATS1 CDC2 NRG1 LATS2 LIF CDK2 CDK4 CTNNB1 PMC9027139__F1 O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications OGT NAGK GALK2 PMC6072467__F4 Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides SI ND2 PMC2675552__F3 Mechanism of action of toll-like receptors (TLRs) TLR1 TLR4 IRF3 PMC9533025__F4 Estrogens, estrogen-like compounds, and endocrine disruptors in adipocytes BMP8B IGF1 FGF21 GDF15 IGFBP2 IL6 NRG4 PMC5798243__F1 Physiological events post-BCG exposure: UC cell exposure to BCG results in A5B1 receptor mediated BCG internalization involving A5B1cross linking CXCL5 CXCL1 CXCL3 PMC11174684__F5 Schematic representation of the hypothetical signaling pathway activated under PEG-6000 treatment in Saragolla and Svevo cultivars TF MYB ERF MAPK6 PMC12232514__F3 Non‐caloric artificial sweeteners on gut health TLR5 MPO MYD88 PMC5821620__F1 Bidirectional E-cadherin/catenin–EGFR cross talk in epithelial biology MTOR SRC CTNNB1 PMC11063508__F1 Schematic diagram of the entire study MDM4 CCNE2 CDKN2A GTSE1 ATR CYCS CASP3 CDK2 PTEN MDM2 CCNB1 CDK4 PMC10034053__F2 Immune cells and immune cell-targeted therapy in chronic pancreatitis IRF3 MX1 IL17A PMC4539082__F2 Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway SMAD2 SMAD4 PMC7290813__F7 Graphical representation of selected intracellular effects and induction of apoptosis in mammalian cells following internalization of Shiga toxin holotoxins (Stx) BAX CAD PAF1 NLRP3 IL16 PMC6515079__F9 Network analysis of proteome datasets in M1 polarized (vs HEL-S-72p DDX5 KRT10 ACTG1 CD59 MSH3 RPSA HES6 KHSRP CNR2 HEL-S-87p HNRNPC CP PS1TP5BP1 YWHAG PMC8017486__F1 The design and application of AE@NPs for enhanced PC treatment STAT3 EGF EGFR PMC11257078__F1 Species differences in bile acid synthesis CYP8B1 CYP7A1 CYP27A1 PMC7290813__F8 Graphical representation of effects in mammalian cells following binding of Shiga toxin (Stx) B subunits to cell surface receptors VWF PAF1 NLRP3 BCR LYN PMC7303777__F2 Insulin signaling pathway BAD FAS MTOR PDK2 INS EIF4E RHEB SDHA TSC2 TSC1 INSR FOXO1 GRB2 PMC11257078__F4 Bile acid crosstalk with sulfur amino acid metabolism CDO1 CYP7A1 pcap PMC11257078__F3 Bile acid regulation of the autophagy-lysosome axis FGF8A LIPA TFEB MTOR ATG5 PMC5854681__F1 Differential control of distinct stages in adult SVZ-OB neurogenesis by different cell cycle regulatory proteins HDAC3 BMI1 CDC2 CDK6 CDK5 HEY2 E2F4 SOX2 BMP2 CDK2 PTEN PMC5517153__F1 Pathway for thiopurine metabolism RAC1 TPMT PMC7898953__F5 Effect of miRNAs on the Hippo pathway and the actin cytoskeleton CDH2 CFL2 FAT4 TAOK1 STK38L AMOTL1 TWF1 CTNNB1 LATS1 LATS2 CSRP3 MICAL3 PFN2 TMSB4X PMC8666369__F8 IPA on CCl4-induced liver fibrosis IL16 SMAD2 PMC6596190__F1 APP can be cleaved through amyloidogenic or non-amyloidogenic pathways PIG59 APP PMC10778465__F1 The antitumor effect of SST receptors after ligand binding BAX SSTR4 SSTR3 SSTR2 SSTR5 SRC SST PMC5069779__F5 MIIP competing with Rac1-GTP to bind the PAK1-binding domain MIIP PAK1 RAC1 PMC6645632__F5 The hexosamine biosynthetic pathway (HBP) in the heart OGA OGT PMC6909129__F1 Pattern Recognition ReceptorsThe anti-adenoviral immune response is triggered by recognition of pathogen-associated molecular patterns (PAMPs) by PRRs CGAS TLR4 IL18 TLR9 NOD2 IRF3 IRF7 TRAF6 MYD88 PMC7930745__F2 TMEM16A regulates EMT and cancer cell migration and metastasis STAT3 EGFR GRB2 PMC3887939__F1 Signaling mechanisms proposed for the mammalian autophagy pathway ATG10 ATG16L1 UVRAG ATG5 VAMP8 PMC3588000__F1 Biosynthesis of Phosphatidylethanolamine (PE) PSD PEMT PC PCYT2 PMC4278340__F1 Menin-mediated regulation of miRNA biogenesis uncovers the IRS2 pathway as a target for regulating pancreatic beta cells DGCR8 DROSHA PMC9216458__F2 CD47–SIRPAlpha-targeted therapeutics: status and prospects GHR CD47 PMC4768069__F2 Bioinformatics analyses reveal changes in expression of genes associated with the Death Receptor Pathway HTRA2 FAS TRADD TANK TRAF2 DIABLO FADD PMC6202673__F1 Proposed model of airway tolerance IL25 TLR4 IL33 IRF4 CCL20 PMC2581748__F2 Activation of the mammalian target of rapamycin (mTOR) pathway can result from numerous glioma-associated genetic changes RHEB NF1 PTEN MTOR PMC5472795__F8 Anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites ATR RAD51 CDC14B BRCA1 RNF168 APC USP1 RNF8 RIF1 PMC1525002__F4 Sequence logo [41] of putative regulatory motif ENO2 HEL-S-68p ENO1 HEL-S-4 ADH5 PMC6434684__F1 Sonic Hedgehog Pathway SUFU PTCH1 SHH SMO PMC7764417__F2 Putative model for the development of (cardiac) lipid-induced insulin resistance CD36 IRS1 PMC4972113__F1 Mechanisms of tumor responsiveness to statins EPB41L5 HMGCR MVP ARF6 PMC5810242__F10 The interrelationships among p-AMPK, p-mTOR, p-ULK1, autophagy and apoptosis ULK1 BCL2 MTOR PMC3281571__F2 MTOR pathway SLC3A2 ULK1 PML BNIP3 PTEN YY1 MTOR SLC7A5 GRB10 MAF1 EIF4B SGK1 ARHA TNF DEPTOR RAC1 IRS1 EIF4E RHEB MLST8 TSC2 RICTOR TSC1 EEF2 GRB2 PMC2768039__F2 Genetic Basis for Kidney Cancer RBX1 TGFA VHL PMC3281571__F1 Simplified view of the mTOR pathway RHEB MLST8 TSC2 TSC1 MTOR IRS1 EIF4E PMC3341446__F1 Illustration of the PI3K pathway signaling pathway TSC2 TSC1 FOXO3A PTEN PMC3335670__F3 Action of the enteropathogenic yersiniae Ysc T3SS effectors (Yops) on host cell signaling and survival CDC42 TLR4 ARHA SRC RAC1 PMC12158951__F1 Two main mechanisms of Fn promoting CRC proliferation BCL9 TLR4 APC LRP5 LRP6 CTNNB1 MYD88 PMC7289953__F1 Mechanisms underlying experimental liver transplant tolerance CD80 TLR4 MSC PMC8601819__F3 Naringenin: A Promising Therapeutic Agent against Organ Fibrosis SMAD2 IL18 SMAD4 RHO TNF CTNNB1 PMC5409051__F5 Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats ANGPT4 HEL-S-22 DAGLA SLC37A4 INSRR ACD PLA2G4C PMP2 UNK PMC6562953__F1 RKIP protein as a signaling modulator in lung cancer STAT3 SHH NF2 PMC8591231__F5 Review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury BAX BAD FAS IGF1 IGF1R IRS1 FADD PMC2871498__F9 Working model for S1P/SK/S1PR interplay during acrosomal exocytosis SPNS2 ABCC1 SKI PMC3071501__F10 Genes mapping to KEGG pathway for hedgehog signaling SUFU SMO RAB23 PMC10586346__F3 Osteogenic differentiation-related signal pathway diagram DSPP RUNX2 ACE2 CTNNB1 PMC6332930__F2 Interferon (IFN)-dependent IFN stimulated gene (ISG) transcription through the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling STAT1 IFNGR2 IFNGR1 IFNLR1 STAT2 IFNAR2 IRF2 IFNAR1 IRF7 IRF8 JAK1 TYK2 PMC5817353__F1 Subcellular compartmentalization of the Fe-S cluster and Moco assembly processes BOLA2B FDX2 MOCS3 CIAPIN1 MMS19 ISCU MOCS2 ISCA2 ABCB7 CIAO1 SUOX MOCS1 BOLA1 ISCA1 FDX1 XDH PMC3289598__F1 Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background CS AQP1 PMC6600680__F7 Mitochondria-mediated apoptotic signaling pathway by JNK and p38 HTRA2 BAX CASP9 BAD CASP3 PMC8212062__F7 Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway BMP4 CD34 PMC3283059__F2 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway displaying transcripts in mitogen-activated protein kinase (MAPK) signaling pathway MAX ECSIT JUN FAS RAF1 EGFR TNF DAO FLNA MEF2C MOS NF1 ERI1 PMC3283059__F4 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway display transcripts in cell cycle pathway DBF4 RAD21 CDC20 PCNA E2F4 CDC6 SMAD2 APC SMAD4 MYT1 SKP2 PMC3428242__F1 Simplified schematic representation of the mammalian target of rapamycin (mTOR) signaling pathway.Notes: Red, pathway inhibitor; Green, pathway activator; Blue, mTOR complex protein.Abbreviation: NOS, not otherwise specified RHEB MLST8 TSC2 RICTOR TSC1 PTEN RHO MTOR PMC9002269__F1 Fine-Tuning Cold Stress Response Through Regulated Cellular Abundance and Mechanistic Actions of Transcription Factors MYB CAMTA2 CAMTA1 PMC8102909__F7 Disruption of the cholinergic anti-inflammatory response by R5-tropic HIV-1 protein gp120JRFL EGR1 CCR5 IL18 CXCR4 OTP PMC8346999__F10 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases NLRP1 UBR5 UBR1 UBR4 RAB39A IL1B PMC9488848__F2 Use of multitarget tyrosine kinase inhibitors to attenuate platelet-derived growth factor signalling in lung disease PTEN GRB2 MTOR PMC2063819__F7 The newly identified NT3-activated signaling pathway TAMALIN ARF6 COIL RAC1 PMC5971440__F15 Arteriosclerotic G3BP1/RIG-I signaling in aortic VSM, a working model CDC42 NFATC4 MAVS LRP6 RUNX2 RAC1 PMC11394960__F8 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the lungs in Lagovirus europaeus infection NLRP3 TLR4 IRAK1 TRAF6 MYD88 PMC11394960__F7 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the liver in Lagovirus europaeus infection NLRP3 TLR4 IRAK1 TRAF6 MYD88 PMC11843905__F14 STRING network of FREM2 EGF ELAVL4 FREM1 TRPC4 FREM2 RYK IGFBP2 MAST2 GRIP1 OMA1 TIMM10 LEO1 ERBB4 FAM221A EGFL6 PITRM1 NPNT OR6T1 CDH24 HMCN1 AJAP1 NRP2 TFAP2A XPNPEP3 HMCN2 CCDC63 SMTNL2 KRT75 ERBB3 TACC2 THOP1 ITGB1 NLN ZDHHC21 HEL-S-75 UQCRFS1 ERBB2 FEZ1 PMC11394960__F9 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the kidney in Lagovirus europaeus infection NLRP3 TLR4 IRAK1 TRAF6 MYD88 PMC5850959__F7A Transcriptomic data shows immunometabolic effects of vitamin D C6 ATR TGFB1 HEL-S-62p LAT ARF1 GSK3B SMAD4 CCNH HDAC3 CDK6 CCND2 YWHAQ E2F4 F2 ATM HEL-S-1 CCNB1 HDAC2 HEL2 YWHAG C7 APC SMC1A HDAC1 PRKDC MEN1 HDAC8 HDAC7 EP300 YWHAZ PMC8346999__F11 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases RAD18 ATR SDE2 UBR1 PCNA PMC7589192__F2 Common signaling pathways of epithelial-to-mesenchymal transition based on Albrecht et al CAD RHO PMC11034122__F7 Different pathways activated in A RPE XK MVD PMC11034122__F6 Comparative physiological, biochemical, metabolomic, and transcriptomic analyses reveal the formation mechanism of heartwood for Acacia melanoxylon CAD PAH PMC6052114__F7 Models of SLC9C1 gating by voltage and cAMP CA11 GC HEL-S-11 SLC9C1 PMC5864870__F1 Anti-gliomagenic effects of different psychiatric and non-psychiatric drugs as demonstrated via in vitro studies JUN EGFR BCL2 MTOR PLK1 MGMT PMC5372812__F1 Schematic representation of the general phenylpropanoid pathway leading to major branches of flavonoid biosynthesis and their possible interaction with miRNAs CSA2 IPMK MVK STS PMC4546649__F6 Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse CYS1 KIF12 PKD1 PKHD1 TCF2 PMC7492232__F1 Proposed mechanisms of sex-related susceptibility to COVID-19 TMPRSS2 ACE2 PMC8526435__F2 Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replication SOCS1 STAT3 STAT1 EGF EGFR PIAS1 SOCS3 JAK1 SRC ACE2 TYK2 PMC4833573__F2 Pediatric Gliomas as Neurodevelopmental Disorders CDKN2A NF1 FGFR1 BRAF PTPN11 MTOR PMC12135226__F2 Lactylation HMGB1 NUSAP1 MRE11A HEL-S-133P LDHB EP300 YTHDF1 HEL-S-87p PMC5730868__F1 Self-renewal pathways in CSCs (A) Wnt signaling pathway, (B) SONIC Hedgehog signaling pathway, and (C) Notch signaling pathway PTCH2 SUFU APC PTCH1 SOX2 SHH SMO CTNNB1 PMC3176054__F5 Proposed model of early pathologic events occurring in the lacrimal glands of C57BL/6.NOD-Aec1Aec2 male mice defined by changes in gene expression JUP DSG2 SRC PMC2839454__F2 Too Old to Fight? Aging and its Toll on Innate Immunity TLR1 CD14 RAC1 PMC11773722__F9 Graphical summary of disrupted immune and structural milieu in the intestinal epithelium of Mpj and Lpr mice CD80 IL16 PDC KIT PMC8056044__F6 Illustration of neuronal and astrocytic pathways implicated in the disease according to the top scoring genes according to our integrated ranking HDAC3 GCS1 PRKCSH EDF1 PFN1 UBE2J2 SRGAP1 APP BDNF PMC3209350__F1 Synthesis, utilization, and regeneration of glutathione and regulation of mTORC1 activity RHEB TSC2 TSC1 GPX1 PMC7196551__F1 Natural products targeting different cell signaling pathway ROS1 ALK IGF1 EGFR SMAD2 CFTR KRAS GATA3 PMC3966314__F3 Impact of miR-215 on cell proliferation, cell cycle, chemoresistance and EMT DTL DHFR MCM3 ZEB2 PMC3436147__F8 Putative mechanisms of the effect of the Kv1 ZAP70 KCNA3 BCL10 LAT MBP CCR7 FOXP3 LCK PMC3258214__F1 Bcl-3 signaling cascade STAT3 IL10 TNF CYLD PMC2916958__F7 Proposed model for the role of NOX4 and DUOX2 in promoting cell cycle entry DUOX2 CCND1 NOX4 CDK4 PMC4601608__F4 Schematic drawing summarizing the physiological regulation of the melanocortin pathway and pathological findings in the in Ankrd26−/− mice CORT STAT3 POMC MC4R ARC PMC8440041__F2 Mucus targeting as a plausible approach to improve lung function in COVID-19 patients RFX3 EGFR MUC2 MARCKS AHR IL8RB PMC8277948__F10 Tumor-Derived Extracellular Vesicles Promote Activation of Carcinoma-Associated Fibroblasts and Facilitate Invasion and Metastasis of Ovarian Cancer by Carrying miR-630 KLF6 FAP PMC3840254__F8 Summary of proposed pathway leading from TGFB1 receptor binding to ROS generation UCP2 TSC2 ROS1 MTOR NOX4 SIRT1 PMC9455275__F5 Identify metabolism-related genes IDO1, ALDH2, NCOA2, SLC7A5, SLC3A2, LDHB, and HPRT1 as potential prognostic markers and correlate with immune infiltrates in head and neck squamous cell carcinoma MAK POLI CYC1 GLA HEL-S-30 MYC CIT PMC9085840__F2 Pathways of mitophagy TBC1D17 OPTN PMC5239781__F1 Complement activation MASP1 C6 CD59 FH HEL-S-62p C2 CD46 CD55 C4B_2 PMC4081624__F1 IGF signaling pathway IGF2R IGF1 GHRH IGFALS IGF1R GHRHR GHR IGF2 SST PMC12190578__F2 Simplified schematic of PpIX synthesis in heme biosynthetic pathway CPOX ABCB6 ABCG2 PMC7003708__F1 Mass spectrometry–based proteomics of mdx fibro/adipogenic progenitors (FAPs) reveals a significant alteration of key metabolic pathways NDUFB6 COX7A1 IDH3B NDUFS5 NDUFV2 NDUFA7 COXFA4 SUCLA2 NDUFS6 NDUFB4 COX4I1 NDUFA3 UQCRH ACADVL MDH2 CPT2 CHKB ECHS1 CRAT HEL-S-133P HK2 ACADS COX5A LDHB SDHD PDHX SDHA RPE PGAM1 SDHB PGAM2 PDHA1 HEL-S-304 ENO3 COX7A2 RPIA HEL-S-68p OGDH SUCLG2 DLD ENO1 SDHC ACLY HEL107 ENO2 NDUFV3 NDUFA9 UQCR10 NDUFA6 NDUFS8 CS NDUFS4 ACAT1 HADHB SUCLG1 NDUFB7 NDUFB3 NDUFC2 FH ACO2 MAL FASN PFKP HEL-S-162eP ACADL NDUFA2 PFKL HEL-S-87p CPT1A NDUFA5 PMC5547213__F1 Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy ULK1 AMBRA1 ATF4 PMC2878012__F5 Model for the role of SQSTM1 in regulating the integrity of the Keap1-Nrf2 cell defense pathway KEAP1 SQSTM1 PMC5373463__F1 Regulatory networks that control intrarenal RAS activity NR1i1 CTNNB1 FGF23 PMC9577257__F2 WNT signaling at the intersection between neurogenesis and brain tumorigenesis CDC42 APC DAAM2 RHO RAC1 DAAM1 CTNNB1 PMC10417677__F3 Anti-inflammatory mechanism of MBPs NLRP3 IL6 TNF PMC8876822__F3 Non-Canonical Host Intracellular Niche Links to New Antimicrobial Resistance Mechanism VWF EGFR ADAM10 PMC3412259__F1 This diagram of BCR/CD19-initiated signaling shows two key outcomes of PI3K activation SYK BTK RICTOR BCR BLNK CD19 MTOR PMC5873983__F1 Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: a one-carbon metabolism candidate gene study MTHFD1 ASL AS3MT FOLR1 TCN2 SLC46A1 MTRR HEL-S-61p TYMS SLC19A1 MTR PMC4360475__F6 Bisphenol-A Affects Male Fertility via Fertility-related Proteins in Spermatozoa EGF SDHB SP1 GPX4 HEL-S-162eP PRDX5 GH1 HNRNPK NCL PMC7781331__F2 WormPaths examples ART1 PCK1 GPD1 PCK2 PDHA1 GPD2 HEL-S-68p HEL-S-49 FBP1 FAT1 AMH HEL-S-26 FAT3 PMC2839169__F1 Simplified illustration of the epidermal growth factor receptor (EGFR) pathway with the RAS/MAPK and PIK3CA/PTEN cascades MAPK1 EGFR PTEN MTOR PMC8989677__F8 Cartoon of mode of action of BNT162b2 in vivo IFNG RIPK3 IFNAR2 GC PDC IFNAR1 PMC4861419__F6 Schematic illustration represents the potential signaling transduction mechanism by which cancer cell-derived exosomes prevent monocyte apoptosis CASP8 CASP3 CASP10 PMC6949840__F3 (1) TNFA, and IL-1B can induce the expression of TGFB NR1i1 IL16 SMAD2 SMAD4 PMC3921549__F1 Carcinogenetic pathway and classification of colorectal cancer APC BRAF KRAS PMC8511458__F2 Interplay Between Non-Canonical NFKB Signaling and Hepatitis B Virus Infection CD40 LTBR APOBEC3A RELB TRAF3 APOBEC3B PMC11311387__F4 Involvement of p53 in cell stress responses and glycosylation-related pathways and the relationship between p53 glycosylation and cancer progression ENTPD5 FUCA1 TIGAR PMC12058482__F3 Molecular mechanisms of epithelial-mesenchymal transition CDH2 EGF COL1A1 SMAD2 SMAD4 PMC12058482__F1 Interaction between inflammatory response and alveolar epithelial cell injury STAT3 NLRP3 IL33 PMC3875243__F1 Characterization of Negative Feedback Network Motifs in the TGFB Signaling Pathway KY C2 SI CIT PMC6712945__F5 Schemes for nanoparticles loaded with specific agents to target TAM signaling pathways NPS CCR2 TLR7 PMC7577085__F2 Signaling pathways activated by MSP and RON TRAK1 NLRP3 MHC2TA TLR4 USF1 GRB2 TRAF6 PMC7487068__F7 Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy NLRP3 CHST6 IL1B PMC8627910__F2 Fragment of the gene network, containing genes associated with PIN1 and genes related to the auxin signaling pathway COPA PIN1 PMC7140485__F1 Canonical and non-canonical pro-fibrotic pathways of transforming growth factor B (TGFB) and Wnt and the pro-fibrotic interleukin 11 (IL-11) pathway IL11 GRB2 PMC2342468__F1 Cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice RYR2 PLN TNC PMC3101043__F2 Endogenous and exogenous regulators of TLR activation TBK1 TIRAP TRAF6 MYD88 PMC6125217__F1 Nodal and Shh Signaling CDON BOC SMAD2 SMAD4 NODAL FOXH1 PTCH1 CRIPTO DISP1 SHH SMO GAS1 GLI3 PMC3985001__F1 The CNS-immune system crosstalk VIP NPY ChAT AgRP TNF PMC9103744__F6 Overexpression of Renin-B Induces Warburg-like Effects That Are Associated with Increased AKT/mTOR Signaling RICTOR APP PDPR PMC8844185__F3 Future Directions in Diagnosis, Prognosis and Disease Monitoring of Adrenocortical Carcinoma: Novel Non-Invasive Biomarkers CYP21A2 HSD17B3 CYP17A1 CYP11B2 PMC4450221__F2 Mechanisms underlying the developmental programming of NAFLD TLR4 FASN IL6 IL1B PMC8733707__F7 ENO3 Inhibits Growth and Metastasis of Hepatocellular Carcinoma via Wnt/Beta-Catenin Signaling Pathway MMP7 ENO3 GSK3B MMP2 MMP9 CCND1 CTNNB1 PMC12058482__F4 Severe acute respiratory syndrome coronavirus 2 infections and epithelial-mesenchymal transition TMPRSS2 STAT3 TREM2 TLR4 SRC ACE2 PMC5187527__F4 Mechanism of estradiol-dependent repression of GD3S in ER-positive breast cancer cells ST8SIA1 TNF PMC2915454__F4 Pathways underlying absorption of cholesterol from the intestinal lumen and its delivery to the liver ABCG8 ABCG5 MTTP ACAT2 NPC1L1 PMC11977258__F4 OB-EC communication VWF TGFB1 BMP4 BMP2 BMP7 PTH RUNX2 PMC8938281__F10 MiR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate Cells SMAD1 LOX DKFZp781O1323 SMAD2 ITGA2 SMAD6 SMAD4 PMC4196276__F5 Entourage: Visualizing Relationships between Biological Pathways using Contextual Subsets EGF IGF1 SHC2 GRB2 SHE PMC1783813__F3 Physiology and immunology of the cholinergic antiinflammatory pathway HMGB1 TLR4 CD14 TNF PMC7907897__F2 NRF2 regulatory mechanisms.A) three reported negative regulatory mechanisms of NRF2 ACOX1 ABCC1 RAD51 KEAP1 GPX4 GCLM BRCA2 AKR1C1 DPP3 XBP1 GPX2 FTH1 BRCA1 LIPH MAF ABCC3 AHR ABCC5 ABCG2 HEL-S-26 ATG5 ABCC2 NOTCH1 HEL-75 PMC6213406__F1 Putative anticancer effects of MTF exemplified by molecular and cellular key events STAT3 IPMK MTOR CCND1 PMC8557262__F1 Possible harm from glucocorticoid drugs misuse in the early phase of SARS-CoV-2 infection: a narrative review of the evidence GC TLR7 ACE2 PMC2710522__F1 Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data STAT3 RINL EGF BAD TGFA SOS1 VAV2 ERBB4 LIMK1 NRG3 PTEN MTOR NRG4 ERBB3 RHEB STAT1 PAK1 RIN1 BTC ERBB2 GRB2 PMC5396097__F3 Autophagy-mediated regulation of macrophages and its applications for cancer TLR4 CCR2 IL6 MTOR CCL2 IL6R PMC5396097__F1 Autophagy-mediated regulation of macrophages and its applications for cancer SH3GLB1 PIK3R4 ULK1 PI3 UVRAG AMBRA1 ATG14 MTOR PMC2002564__F1 Arterial–venous specification in the developing embryo EPHB4 FOXE1 SHH PMC7106955__F1 Main mechanisms of ferroptosis SLC3A2 TFRC GPX4 ADA PMC3406705__F8 Hypothetical model elucidating the regulation of phosphorylated FAK expression through an integrin A5 and B1-mediated MEK-ERK1/2-dependent pathway after ESWT ITGB1 CTNNB1 PMC11882760__F3 DUBs on periodontal inflammation and bone resorption TRAF4 STAT3 NLRP3 USP12 CD9 BMP2 IL18 TRAF6 OTUD1 CYLD CD47 SEC23B PMC8396359__F4 Duality of Caspases in Cancer, as Told through the Fly ATR ATM SSB PMC4586293__F2 Neurohormetic Phytochemicals: An Evolutionary - Bioenergetic Perspective RHEB TSC2 TSC1 IGF1 FOXO3A MTOR SIRT1 PMC5428057__F6 Schematic overview summarizing the functional significance and regulation of COX-2 in PDAC EGF SP1 EGFR GRB2 PMC5745276__F1 Wnt pathway can be classified as canonical and non-canonical GK3 RNF43 ZNRF3 CTNNB1 PMC3117391__F3 Pathway for getifinib and docetaxel to generate the synergistic effects on KRT8 MAPK1 STAT3 JUN RAF1 SOS1 EGFR SOCS3 PIN1 RAC1 MAPK3 MAPK14 HRAS BNIP2 CASP3 BCL2 FGFR3 JAK1 SRC RRAS2 PMC5789355__F1 Signal transduction through the mTOR complexes RHEB STAT3 TSC2 EIF4B CAD TSC1 SGK1 PTEN MTOR DEPTOR EIF4E PMC6879499__F3 Construction of pathway map and PPI interaction map PPARG PIK3CA KEAP1 PXN GSK3B BNIP3 HIF1A EGLN1 MAPKAP1 CAMKK2 NF1 PDPK1 AKT1S1 MDM2 PTGFR MAPK1 RYR2 NAMPT DVL2 DEPTOR IRS1 EIF4E RHEB MLST8 TSC2 RICTOR TSC1 CRABP2 CDKN1B PLCB1 PTGER1 RAP1A GRB2 SIRT1 DDIT4 ULK1 RPS6KA1 BRAF PML PTEN MTOR PDE4B PRR5 STRADA EEF2K INSR RB1CC1 PPARGC1A FZD1 EIF4A1 SIRT6 RPTOR EIF4B PARG HEL-S-7a EIF4EBP1 PPP2R1A ARHA RAC1 PARP1 FOXO3A HEL-S-69p NFKBIA LPIN1 CREBBP EP300 YWHAZ PMC5745276__F3 Cross-Talk between the Wnt, Notch and Sonic Hedgehog Pathways- Beta-catenin can drive activation of Notch signaling by increasing expression of the JAG1 gene, which encodes the Notch ligand Jagged1 GK3 SHH SMO SFRP1 CTNNB1 PMC7106955__F3 Hippo signalling pathway TF EMP1 TFRC CAD FACL4 NF2 NOX4 PMC8820687__F1 Brain as a source and a target of prolactin in mammals PRLR PRL GRB2 SRC PMC3645678__F3 Involvement of Cdc42, Rac1 and RhoA in vesicle trafficking, cellular transformation, invadopodia formation and metastasis CDC42 RHO RAC1 PMC8108463__F3 Endogenous retroviruses in the origins and treatment of cancer MAVS TLR3 IRF7 PMC9251540__F1 SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review SMAD2 APC GSK3B LRP5 LRP6 RUNX2 WNT10A CCND1 SFRP1 CTNNB1 FGF2 PMC9251540__F3 SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review RAN GSDMD NLRP3 CASP5 CASP4 IL1B PMC9251540__F2 SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review HEY2 NOTCH2 NOTCH3 HES1 NOTCH1 HES5 PMC8885627__F1 Macrophages and Metabolic Reprograming in the Tumor Microenvironment CSA2 CXCL12 CXCL8 PMC9579717__F6 Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signalling MLST8 CLIC1 DEPTOR PMC3146245__F2 Genetic model for nuage assembly and piRNA pathway genes in mice TDRD7 TDRD1 HIG-1 MOV10L1 TDRD6 MAEL PMC5741148__F1 Regulation of the FoxO1/3 activity by phosphorylation FOXO1 FOXO3A F3 IRS4 IRS1 PMC6349168__F1 Molecular interactions in Immunometabolism governing lipid metabolic disorders STAT3 CD36 UNK PMC125566__F7 Negative regulation of the Wnt–Beta-catenin pathway by the transcriptional repressor HBP1 APC CTNNB1 PMC6400832__F1 The nutritional sensing O-GlcNAcylation OGA OGT PGM3 PMC4998060__F2 Signaling network that regulates ISC activity in response to injury EGFR HEL70 PMC2206598__F4 Regulatory networks sensitive to tyrosine kinase inhibitors in H3255 and MKN45 cells revealed by PhosphpScan-SILAC study JUP RAN REN EPHA2 EGFR AK1 PMC4571978__F1 A, diagram of the workflow of mitochondrial proteomic studies CTRL CAD KIN SET PMC2075270__F1 Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle EEF2K TSC1 PI3 EEF2 MTOR INS IRS1 PMC4038907__F4 Progesterone and breast cancer EGF SP1 CDK2 GRB2 CCND1 PMC4143405__F5 Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer IRF4 XBP1 PAX1 SET ME3 FOXO1 CCND2 PAX5 SHH CCND1 BCL6 HES1 RET NOTCH1 PMC8222665__F3 Tumor-Associated Macrophages: A Potential Target for Cancer Therapy CD40 CXCL12 CCR2 SIRPA CXCL2 CCL2 CXCR4 CD47 PMC6293973__F1 The Receptor for Advanced Glycation Endproducts (RAGE) and Mediation of Inflammatory Neurodegeneration HMGB1 PMC5974440__F2 Regulation of stemness in the intestinal stem-cell niche EGF EGFR GSK3B LRP5 GPR49 CTNNB1 PMC9691389__F6 Integrated Analysis of mRNA and lncRNA Expression Profiles Reveals Regulatory Networks Associated with Decompensated Cirrhosis GABARAP FCAR RAB4A HLA-DOA SMAD2 ARF6 ZFYVE9 THBS3 EPN2 VPS28 AP2A1 LDLR AP2A2 ACP5 FCGR2A FCGR3B SLC11A2 AMPH FCGR2B ERBB4 HGSNAT TPP1 CHMP4A HGS NAPSA GABARAPL2 HLA-A CD68 PS1TP5BP1 PMC5966388__F6 Dysregulation of the MiR-449b target TGFBI alters the TGFB pathway to induce cisplatin resistance in nasopharyngeal carcinoma CDH2 TGFBR2 TGFBI TGFBR3 PTEN TGFBR1 PMC8586445__F1 T-Cell Metabolism in Graft Versus Host Disease SLC3A2 FAS HK2 MTOR PMC7492601__F7 Biological mechanism of lncRNA C1RL-AS1 in GC GSK3B CTNNB1 PMC11054595__F2 Mechanisms or pathways associated with sepsis-induced ALI BAX TLR4 MYD88 AQP1 PMC5431011__F7 Glycerophospholipid metabolism is induced in parasitized A LPL PGS1 TG LPGAT1 GPAM AGPAT3 CDS1 HEL-S-5 PC CS PLA2G2E PMC10380468__F2 Investigation of the Effects of Metallic Nanoparticles on Fertility Outcomes and Endocrine Modification of the Hypothalamic-Pituitary-Gonadal Axis HBEGF EGR1 LHB GNRHR EGFR FSHB PMC4115674__F1 Ras/MAPK signal transduction pathway CBL SPRED1 SOS1 NF1 SHOC2 BRAF CS GRB2 PMC6747293__F1 Stress-induced senescence ATR CDK6 CDK2 ATM CDKN3 CDK4 PMC111167__F1 BR biosynthesis pathway CS GH1 CPD PMC3193406__F3 NIK stabilization as a mechanism of non-canonical NFKB signaling ZFP91 TRAF3 TRAF2 PMC3193406__F2 Positive and negative domains regulating p100 processing RHD RBX1 SKP1 REL PMC3193406__F1 Canonical and non-canonical NFKB signaling pathways CD40 LTBR BCR RELA RELB PMC5136497__F3 Involvement of cellular miRNAs in the signaling pathway of the immune response in sepsis IRAK1 IRF1 IRF7 IL1A TRAF3 TRAF6 IRAK4 MYD88 MAP3K7IP1 COX2 TLR4 TLR8 TLR7 PMC12151073__F2 Mechanisms by which lactate modulates the innate immune responses COX2 TLR4 TRAF6 MYD88 PMC4594188__F1C Significant signaling pathway networks in each group SP100 MYC REL DEFA1B PITX2 PMC5817863__F1 Schematic view of the circadian pathway NPAS2 TIMELESS CSNK1E PER1 NR1D1 CRY1 RORB RORA PMC4594188__F1E Significant signaling pathway networks in each group RARA CACNG2 ARFGEF2 NCOA7 PMC4594188__F1A Significant signaling pathway networks in each group HEL-S-99n SP1 PROC MYC PMC9597979__F7 Transcriptional regulation mechanism of wheat varieties with different nitrogen use efficiencies in response to nitrogen deficiency stress TF EBF2 PMC5441174__F7 Schematic diagram of the FOXM1/Beta-Catenin complex in human osteosarcoma cells FOXM1 TCF4 CCND1 CTNNB1 PMC5056611__F1 SETD1A-induced miRNAs suppress gene expression modules SETD1A BTG2 EZH2 PMC5514447__F2 Low-dose triptolide and aspirin suppress NFKB survival pathways RAMP2 CADM1 HIF1A MMP11 MAOA JAM2 POSTN VSNL1 CD93 ITGA2 FLT1 F2RL1 GHR SOX4 TSPAN7 AQP5 EFNB2 FBN1 ESAM ADM SP1 LAMC2 RASGRF2 IL1A TBX5 EMP1 BMP6 ENG SEMA3C HPGD LAMB3 EDNRB ELK3 DACH1 AKAP12 LAMA3 HGF CD36 MEOX2 IGFBP2 CDKN2B DPP4 AHR ACVRL1 IL1B ICAM2 PLOD1 DLL4 LIF KIT RTP3 AFAP1L1 KITLG FOXF1 MFAP2 CALCRL VIPR2 HILPDA TNFSF10 FGF18 PMC6221181__F1 Glucocorticoids regulate NK cells and ILC1s functions upon MCMV infection IFNG RHPN1 TSC22D3 PMC9010746__F1 Controlling neural territory patterning from pluripotency using a systems developmental biology approach MAX SMAD1 DKFZp781O1323 SMAD2 JAG2 NODAL PMC4862604__F4 Repair Pathway Choices and Consequences at the Double-Strand Break RAD51 BRCA1 BRCA2 AHR POLE PALB2 PMC3295626__F1 JAK-STAT intracellular signaling pathway in myelofibrosis SOCS1 EPO MTOR PMC4862604__F3 Repair Pathway Choices and Consequences at the Double-Strand Break RAD52 RAD51 BRCA1 BRCA2 FANCM RTEL1 POLE PALB2 BLM FBXO18 PMC9097270__F6 DNA repair, recombination, and damage signaling MSH4 NEDD8 RAD51 BCL2 GEN1 APAF1 PMC7730291__F1 Wnt–FAK signaling crosstalks and inhibitors PORCN APC LRP5 LRP6 GRB2 SRC PMC4862604__F2 Repair Pathway Choices and Consequences at the Double-Strand Break BRCA1 ATM RIF1 PMC9066194__F4 Function and Regulation of SAPCD2 in Physiological and Oncogenic Processes EZH2 CTNNB1 PMC8577250__F1 Low-intensity pulsed ultrasound stimulates proliferation of stem/progenitor cells: what we need to know to translate basic science research into clinical applications CCNE1 TLR4 CNN2 CCNA2 MTOR CCNB1 REL CCND1 PMC6522871__F2 Small molecule inhibitors and the ALK-Smad signaling pathway SMAD2 SMAD4 PMC7033031__F9 TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching TLR4 CXCL1 CCL2 PMC3723343__F3 Cripto/GRP78 modulation of the TGFB pathway in development and oncogenesis SMAD2 CRIPTO NODAL SRC PMC6466717__F2 Biosynthetic pathway of Plasmalogens FAR1 HEL-S-5 PMC11546748__F2 Molecular and hormonal pathways contributing to insulin resistance in gestational diabetes IL18 IL6 MTOR CCL2 PMC5706779__F3 Novel Mechanisms and Functions of Complement RPE HEL-S-62p TNF CTNNB1 CP PMC9923233__F7 Screening for diagnostic targets in tuberculosis and study on its pathogenic mechanism based on mRNA sequencing technology and miRNA-mRNA-pathway regulatory network UBE3A EGF SYNRG USP28 ARF1 ZNF148 DNM3 HLA-DPA1 XPC VAMP7 GCS1 CYFIP1 CYFIP2 CAMK2D USP1 TTN GORASP2 WASF1 ZBTB16 PMC2814418__F8 VDR-dependent and auxiliary pathways that lead to deltanoid-induced monocytic differentiation of myeloid leukemia cells NR1i1 EBP CD14 PMC4851692__F4 Effects of C10 on gene expression PCK2 PDK4 ACADVL PDK3 NDUFC1 PMC7137344__F1 Functional alterations and HSC aging mechanisms RHEB TSC2 ROS1 TXNIP GSK3B CD160 MTOR JAK1 SELP PMC6771146__F6 String network of proteins (encoded by the differentially expressed genes (DEGs)) involved in signalling pathways FRZB TCF7L2 PRL KIT ERH KITLG PMC6771146__F4 Co-expression analysis of genes overexpressed in Puławska pigs, characterized by high feed conversion values ND1 ND4L COX1 S100A10 ANXA2 ND4 ATP6 CYB ATP8 COX2 ND5 ND6 FGL2 ND3 PMC11593353__F2 Differential Gene Expression Associated with Idiopathic Epilepsy in Belgian Shepherd Dogs STAT1 STAT2 IRF9 PMC4384327__F3 APP protein-protein interaction networks STXBP1 CXCL12 LYPD3 HSPG2 LAMA1 KALRN FLOT2 CCL7 APP P2RX7 ACHE LRP8 SYNRG SORL1 APOE CXCL16 CD14 DLG4 SNCA RELN SPN HGS FTL LPAR2 FPR2 ADA PMC5630445__F3 The role of toll-like receptor 4 in tumor microenvironment TLR4 CD14 IL1B PMC7801279__F2 Drugs treat VaD through regulating inflammation-related signaling pathways NLRP3 TLR4 SIRT1 IL1B MYD88 PMC7842189__F2 Microglia-Tissue Consensus Module Microglia Disease Time Course and Pathway Annotation SCARB2 SOCS1 LCP1 PKN1 PDCD1 ARF6 TLR9 CD22 PTPRC CTSZ PSEN1 QSCN6 CTSC DOK1 HEL-S-42 TYROBP NOTCH1 TPT1 CST7 STAT2 PLAUR INPP5D NCF4 B2M PTBP1 PLEKHO1 c-fgr IL1RN IFNAR2 ITGB5 BHLHE41 CDK9 SDC3 CDC42 VASP ARHG MAVS DEF6 NFKB2 IFIH1 PML DHX58 ITGAX SNX9 TREM2 PSD4 EBI3 TLR7 MFNG ARHGEF2 CEBPB PLD4 CD81 CXCL13 PFN1 CD14 RAVER1 SEMA4D ARHGDIB TLR1 RUNX1 PAF1 FCER1G LILRB4 LPIN1 RRAS TYK2 PS1TP5BP1 PMC4170139__F4 Late signaling events in de novo cytokine/chemokine production SYK FYN BCL10 LAT MAL LYN GRB2 MTOR TRAF6 TNF GAB2 MYD88 PMC4085879__F2 Targets in T-ALL: PI3K/AKT/mTOR, cyclin D3:CDK4/6, BRD4/MYC BRD4 CDK6 PTEN MTOR CDK4 PMC8690056__F1 Nicotinamide and acute kidney injury NAPRT SARM1 HEL-S-90n NAMPT PMC11544004__F9 Impact of the environment on NK cells: Phytoncide model IFNG TPH1 IDO1 AHR AHRR CYP1B1 CYP1A1 ASB2 PMC8021541__F7 LncRNA H19 regulates sensitivity to EGFR‐targeted therapy through different mechanisms EGFR SRC PMC3944232__F7 Schematic illustration of LEF1/CYLD and cIAPs in the modulation of RIP1 deubiquitination and triggering of apoptosis via caspase-8 CYLD LEF1 PMC11544004__F5 Dynamics of activation signaling in NK cells in contact with cancer and stressed cells ZAP70 CD48 SYK VAV3 ULBP3 VAV2 LAT ULBP1 VAV1 MICA ULBP2 RAC1 IFNG CRK CBL FOXO1 GRB2 MICB SRC BAG6 PMC11955616__F4 Function and Regulatory Mechanisms of the RIG-I Signaling Pathway in Lung Cancer (By figdraw) TBK1 MAVS IRF3 IRF7 PMC8466094__F2 Crosstalk between Autophagy and Inflammatory Processes in Cancer IRGM SQSTM1 ATF2 MTOR MYD88 PMC11955616__F3 Function and Regulatory Mechanisms of the TLR Signaling Pathway in Lung Cancer (By figdraw) TLR1 TLR3 TLR4 TLR9 TLR8 TLR5 IRF3 IRF7 TLR7 TLR10 MYD88 PMC11955616__F2 The cGAS-STING Signaling Pathway in Lung Cancer Immunotherapy (By figdraw) ESYT3 TET2 GPR162 TBK1 CGAS NR1D1 WEE1 IRF3 PINX1 PMC8021541__F2 LncRNAs sponge microRNAs and then regulate radiosensitivity through different signaling pathways CDH2 MBNL3 CARM1 EGFR HOXA10 MMP2 PTEN MMP9 PMC5225216__F2 Hypothesis of intercellular energy relocation triggered by gut microbiota RAF1 TIRAP PMC5225216__F1 Intracellular energy relocation in fat body cell of Drosophila and immune cell of human TIRAP IRF3 MYD88 PMC4426903__F3 Evolutionary Changes in Promoter and Enhancer Activity During Human Corticogenesis TBX2 EGF SMAD1 DKFZp781O1323 TBX18 EGFR SMAD2 SMAD4 NODAL NID1 NID2 COL1A1 FOXC2 BMP4 COL4A1 FBLN2 FBN1 SOX13 COL1A2 SP1 SMAD6 TGFBR3 COL13A1 ENG COL18A1 FBLN5 PMC7550584__F3 Schematic pathway for DEP-mediated olfactory dysfunction CYP26B1 CFAP69 SYNPR IL6 IL1B PMC4827226__F7 Working model of how the EphA1-activated SDF-1/CXCR4 signaling promotes EPCs’ homing to HCC neovascularization ELL CXCR4 PMC7135251__F4 IPA cellular view of: A) 15 affected molecules in the significant Protein Ubiquitination pathway CDC42 UBE2W ELL NODAL SKP2 RUNX2 TRAF6 HEL-S-276 DNAJC2 STUB1 FOXH1 USP15 TLX2 APP LPP USP47 UNK NR1i1 ANAPC10 SMAD6 HEL-S-89n IRF7 PITX2 SKI RUNX3 PSMC4 HEL-117 USP14 HDAC1 UBE2H UBE2E3 GSC GRB2 PMC7846875__F10 Schematic drawing to illustrate the inhibitory effect of GPs on NFKB and TNFA signal pathway and inhibitory of apoptosis of endothelial and epithelial cells TLR4 VCAM1 IL1B MYD88 PMC5854325__F1 Death receptor-mediated apoptosis signaling FAS TRADD TNF FADD PMC7822913__F7 Hypothetic model of Abcc6 function in cholesterol homeostasis of mice PCSK9 LPL IPP ABCB11 ABCB4 APOE FDPS PMC9604914__F2 Bruton’s Tyrosine Kinase Inhibitors: The Next Frontier of B-Cell-Targeted Therapies for Cancer, Autoimmune Disorders, and Multiple Sclerosis SYK CD79A BTK PLCG1 BCR BLNK CD19 LYN MTOR SRC PMC3899973__F1 Canonical signaling of muscarinic receptors EGF FYN EGFR SRC PMC2761207__F1 Major pathway of the conversion of propionyl-CoA into succinyl-CoA in human cells MMAA MMACHC CBL PCCA PCCB MCEE PMC4352295__F3 Co-regulation analysis among 6 potential internal control genes (ICGs) RPLP0 IL4 TUBB PSEN1 TNF MYC FOS IFNG GTF2B HEL-S-69p APP HPRT1 MBD2 PS1TP5BP1 PMC3353386__F5 NS1 protein of influenza A virus suppresses interferon-regulated activation of antigen-presentation and immune-proteasome pathways NFE2 HLA-E CDA IFIT3 IRF1 PSMB10 CTSS TAP2 HLA-A PMC4259949__F1 Base-excision repair OGG1 POLE PMC7099013__F2 Ingenuity pathway analysis of drug pharmacodynamic targets, associated immunophenotype markers and topo II GPR34 STAB2 HLA-DRB1 CLEC11A PMC6679095__F2 The PI3K/AKT/mTOR/NFKB Pathway RHEB MLST8 TSC2 RICTOR TSC1 INPP4B PTEN MTOR DEPTOR PMC5528312__F2 RNF8‐ and RNF168‐dependent ubiquitin signaling pathway at DSBs is stimulated by CHD4‐ and p400‐mediated chromatin remodeling CHD4 BRCA1 RNF168 RNF8 ATM MDC1 PMC4614871__F3 Different regulation of DSB repair pathways in somatic cells and XY body RAD18 TOPBP1 ATR RAD51 BRCA1 RNF168 H2AX RNF8 ATM MDC1 PMC2685917__F9 Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells BAX BAD IGF1 EGFR IGF1R PMC5216469__F3 Regulatory feedback mechanisms govern Etv2 expression GATA2 ETV2 RCAN1 CREB1 PMC3337715__F1 Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure RHEB ELF4 TSC2 BAD RICTOR TSC1 BCL2 PTEN MTOR IRS1 PMC7278993__F8 Schematic diagram showing the pathways involved in the pathogenesis of vascular calcification (VC) in chronic kidney disease (CKD) SFRP5 SFRP4 WNT3A CTNNB1 PMC7328278__F8 Downregulated miR-18b (miR-18b-5p) signaling pathway in fALS linked SOD1 mutation RARB BCL2 HIF1A MEF2C PMC6329466__F1 Neurotrophic-tropomyosin receptor tyrosine kinase (NTRK) receptor signaling pathway and inhibitors NGF NTRK2 NTRK3 BDNF PMC10950892__F2 Shows the benefits of Warburg and molecular signaling RHEB GLUD1 TSC2 HEL-S-304 TSC1 GLS HK2 PTEN HIF1A EIF4E PMC11027102__F3 Blockade of the CD47-SIRPA signaling pathway initiates an adaptive immune response to kill tumor cells CGAS SIRPA CD47 PMC7326282__F8 MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer LATS1 STK4 PMC6285187__F8 Illustration of the working mechanisms for FGF21 prevention of spontaneous and diabetes-induced germ cell apoptosis FGF21 GSK3B MDM2 SIRT1 PMC9207356__F2 Physiological and pathological roles of the Hippo‐YAP/TAZ signaling pathway in liver formation, homeostasis, and tumorigenesis LATS1 MOB1A MOBKL1A LATS2 RHO VGLL4 PMC7183688__F1 Participation of TNFAIP3 and UBE2L3 in regulation of NFKB activity under TNFA signaling MAP3K7IP1 TNFAIP3 RIPK1 UBE2L3 PMC7767977__F1 Illustration of the neuroprotective pathways following GHS-R1A activation by AG or ghrelin agonists in neurons and astrocytes BAX MFN1 ULK1 IL6 UCP2 TFAM TSC2 TSC1 HEL-S-162eP MFN2 NRF1 ATG5 SIRT1 ULK2 PMC3733118__F2 Genes of innate immunity and the biological response to inhaled ozone CD44 TIRAP TLR4 IL6 MYD88 PMC6384086__F11 Cofilin regulating the actin cytoskeleton and initiating PHEV entry CDC42 GIP RAC1 PMC8983057__F5 Peripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease: miRNA and mRNA Regulation HBEGF CXCR1 VCAM1 RHO IL8RB PMC4647217__F10 microRNA-31 modulates skeletal patterning PAX5 PAX2 PAX8 PMC7502313__F1 Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review BCL2 ATF4 EIF2A XBP1 TRAF2 PMC8103676__F7 Persistent Giant Algal Virus, with a Unique Morphology, Encodes an Unprecedented Number of Genes Involved in Energy Metabolism SDHD SDHA SDHB HEL-S-5 FES SDHC PMC312742__F9 Role of E2F1 in the DNA damage response ATR E2F2 E2F3 ATM MDM2 CDK4 PMC7911501__F1 TLRs are involved in regulation of Mycobacterium tuberculosis (MTB)-induced production of proinflammatory cytokines TLR4 TLR9 PMC7751760__F5 Cellular pathways regulated by H2S in renal diseases FYN FOXO1 SMAD2 TAB3 MAL SMAD4 IRF3 TRAF3 TRAF6 MYD88 PMC2860693__F8 Simplified model of the signaling pathways regulating radiation-induced bystander effects STAT3 IGF1 COX2 IL33 ATM IGF1R IL6 TNF LEF1 PMC7870688__F1 Crosstalk of canonical and noncanonical TGFB signaling pathways associated with renal fibrosis and inflammation in diabetic nephropathy SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC3012432__F7 Diagram illustrating the PS–Tyro3–Akt cell survival signaling pathways BAX BAD TYRO3 MDM2 PMC10750202__F2 Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation MAP3K7IP1 SMURF1 APC LRP5 HDAC5 LRP6 SMURF2 DLX5 RUNX2 CTNNB1 PMC8355060__F1 Transcription Factors CREBH, PPARa, and FOXO1 as Critical Hepatic Mediators of Diet-Induced Metabolic Dysregulation CREB3L3 TG GSK3B PMC9083497__F5 Chronic activation of MUC1-C in wound repair promotes progression to cancer stem cells STAT3 ARID1A BRD7 PBRM1 ARID2 NOTCH1 PMC7180296__F6 MetaCore‐based analysis of two major KEGG pathways and their regulatory gene interactions in skeletal and cardiac human fetal mesoangioblasts (MABs) MYOG ATR HEL-S-11 AKTIP CP PMC5937716__F3 Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration NAT2 GABARAP RAN STAR LEP CALY AP1S1 INA LEPR TAP1 CS TEP1 MECR SAG SOST SORT1 TRPA1 PMC2655244__F8 Proposed model for the signaling pathway of Cao-induced keratinocyte differentiation PIP5K1A CTNNB1 PMC5704294__F1 Proposed activation pathway and domain structure of Nrf1 MAF NGLY1 NRF1 DDI2 PMC11967982__F13 C-type lectin receptor signaling pathway (Pathway ID: hsa04625) from KEGG pathways TH TRO SYK NLRP3 FRY ARHA MDM2 CCL2 CAP1 CCL17 PMC11985188__F4 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in p53 signaling pathway in the pathogenesis of esophageal cancer WTAP YTHDF2 CDK2 PTEN MDM2 CPSF4 PMC11985188__F3 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in Wnt/Beta-catenin signaling pathway in the pathogenesis of esophageal cancer FOXP4 MMP2 ZEB2 VEGFA CTNNB1 PMC11985188__F2 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in PI3K/AKT/mTOR signaling pathway in the pathogenesis of esophageal cancer S100A7 EGFR SOX2 MTOR PMC5467784__F7 Genes associated to tumorigenesis and/or cancer progression found differentially methylated in HA22T/VGH sorafenib treated cells STAT3 SMAD2 PRKCZ ATF2 MTOR MAP3K14 IKBKG CSF3R PIK3C2B STAT5B MMP3 TRIB3 BIRC3 CCND3 MMP7 PIM2 CSF2 AIM2 RAC1 FOS PREX1 TSC2 CDKN1A c-fgr FOXO3A NFIB TAOK3 NKX2-8 JAK1 PMC6097681__F4 TLR4-mediated activation of the ERK pathway following UVA irradiation contributes to increased cytokine and MMP expression in senescent human dermal fibroblasts CD40 IFNE TIRAP FRK CTSK TLR9 CD14 CPO TNF TRAF6 IRAK4 RAC1 TLR4 IL18 NPB TLR7 MIP LBP FADD PMC8379279__F1 Model assumptions PTEN ARHA SRC PMC5036929__F2 Drosophila JNK pathway TRAF4 HEL70 TRAF6 RAC1 PMC8103095__F3 miR‐33 regulates hepatic lipoprotein metabolism, fibrosis, and regeneration ATP8B1 HADHB CDK6 HMGCR ABCB11 CROT CYP7A1 APOB SKI ABCA1 CPT1A CCND1 PMC4362780__F3 Poly(ADP-ribosyl)ation in DNA Damage Response and Cancer Chemotherapy PNKP DDB2 MRE11A BRCA1 APTX APLF SSB PMC11985188__F7 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in MiR-Axis signaling pathway in the pathogenesis of esophageal cancer PBX3 PTEN VEGFA PMC6492270__F1 In response to injury, there are significant and dynamic changes to the OGlcNAc sub-proteome OGA OGT SP1 GSK3B XBP1 PMC9551334__F9 Acute Manganese Exposure Modifies the Translation Machinery via PI3K/Akt Signaling in Glial Cells RHEB TSC2 TSC1 EEF2 PTEN SRC EIF4E PMC7417625__F2 MALAT1 and miR-200c regulate expression of each other through the sponging mechanism CDH2 PTEN ZEB2 PMC7912185__F2 Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review WNT10B APC LRP5 LRP6 SFRP1 CTNNB1 DKK3 BCL9 TG SFRP4 DKK1 DKK2 WIF1 PMC3328896__F2 Cbl-b functions as central gate keeper of T-cell activation ZAP70 PLCG1 FYN APC VAV1 LCK PMC6173124__F1 Role and regulation of host microRNAs in hepatic schistosomiasis NR1i1 STAT3 STAT1 IL33 PMC10253263__F6 Signaling pathway of PNPLA3-I148M-induced activation of LX-2 cells ABCG1 PNPLA3 TIMP1 MFN2 MMP2 COL3A1 HEL-S-44 PMC5027901__F1 Listeria monocytogenes and the inflammasome: from cytosolic bacteriolysis to tumor immunotherapy AIM2 IRAK1 PMC8389007__F8 Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production P2RX7 NLRP3 TLR4 IL1B PMC3970924__F2 Molecular pathology of FLS in RA JUN FAS PTEN SRC TNF FOS PMC6198989__F6 Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk TGFBR2 PDGFD PDGFRA EDNRA SEMA5A CDKN2B TCF21 LMOD1 TWIST1 TGFBR1 PMC7746877__F1 Signaling pathway of EMT APC RHO CTNNB1 PMC6612501__F1 TLR4-mediated inflammatory signaling pathway in the rumen epithelium IFNG STAT1 TLR4 IRF3 MYD88 PMC7746877__F2 Therapeutic potential of BMSC-derived exosomes for PF and the potential molecular mechanisms APC RHO CTNNB1 PMC3132567__F8 Cross-talk between Epidermal Growth Factor Receptor and Hypoxia-inducible Factor-1A Signal Pathways Increases Resistance to Apoptosis by Up-regulating Survivin Gene Expression EGF EGFR VHL PMC8096065__F1 Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks ERCC1 RAD51 PCNA BRCA2 ATM PARP2 POLN PARP1 PMC7689008__F1 Cell adhesion molecules (CAMs) regulate protein synthesis machinery TF FYN PTEN MTOR SRC EIF4E PMC10215085__F9 Hypothetical molecular mechanism model was developed for the influence of starch on the growth and proliferation of B HCN4 HCN2 PFKL PMC9578583__F3 Diagram representing the enzymes involved in the 11 steps of the glycolytic and methylglyoxal pathway and tricarboxylic cycle found in the rumen epithelium of sheep FH HEL-S-133P HEL-S-67p GLO1 CS ME1 PDHX DLAT HEL-S-68p OGDH HEL-S-162eP LDHD DLD HEL-S-87p HAGH PMC6677558__F1 Model of the regulation of light-mediated AS RFWD2 HPR PMC7322557__F1 Molecular connections between components of circadian clocks and the immune system IL16 S100A8 CCR2 EZH2 CCL8 CCL2 NFIL3 RORA PMC3662247__F3 PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity PINK1 RAF1 ULK1 BNIP3 PTEN TIGAR MTOR TRAF6 PI3 MDM2 ATG5 APAF1 CDC2 BAX HMGB1 CASP9 OPA1 UVRAG VMP1 TSC2 TSC1 ATG12 AMBRA1 CASP3 FADD PMC6606851__F8 Pathway activity measured with luciferase reporters for canonical signaling (STF) WNT3A APC ROR2 GSK3B CTNNB1 PMC3662247__F4 PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity NBR1 HMGB1 TREM1 TBK1 TIRAP TLR9 AIM2 TLR5 IRF3 IRF7 TRAF6 MYD88 CD24 TLR1 TLR3 TLR4 TLR8 TLR7 PMC5521727__F1 Hsp90 and Physiological Stress Are Linked to Autonomous Transposon Mobility and Heritable Genetic Change in Nematodes TES NR1C1 POLN PMC12131761__F1 Analysis flowchart MVP MIP PMC7522761__F1 Interferon signaling from dermatomyositis skin analysis IFNG BAX STAT2 PSMB8 IRF9 IFIT1 PIAS1 IRF1 TYK2 PMC1995599__F2 MOLECULAR AND CELLULAR MECHANISMS OF THE ANABOLIC EFFECT OF INTERMITTENT PTH BAD SMURF1 PTH RUNX2 PMC8257499__F5 Rare copy-number variants (CNVs) in spina bifida (SB) cases participate in SB-relevant pathways and affect various aspects of one-carbon metabolism OMG ALDH7A1 AVIL BHMT2 PMC12158998__F6 Molecular targets and mechanisms of cortex mori for lung cancer treatment: a network pharmacology study, molecular docking and in vitro and in vivo experimental validation CASP9 EGF ENG BAD RASSF1 POLK AK3 ERBB2 PAH FHIT RET PMC7522761__F2 Ingenuity Pathway Analysis of candidate genes downstream of interferon-alpha signaling from dermatomyositis skin analysis STAT3 HEL60 IF1IB1 STAT2 IRF9 IRF1 IRF3 IRF7 RSAD2 CXCL10 MYC STAT1 ISG15 ApoL6 OAS2 PMC12158998__F5 Molecular targets and mechanisms of cortex mori for lung cancer treatment: a network pharmacology study, molecular docking and in vitro and in vivo experimental validation MAX CASP9 RARB POLK CASP3 CDK2 PTEN SKP2 FHIT PMC7522761__F5 Ingenuity pathway analysis of several candidate genes with oncogenic and tumor suppressing properties downstream of IFNG signaling STAT3 STAT2 IRF9 IRF1 IRF7 IRF8 TNF MYC CD44 IFNG POSTN CDKN2A STAT1 IDO1 NPM1 NFKBIA IL1B PMC7522761__F4 Ingenuity Pathway Analysis of candidate genes downstream of interferon-alpha signaling from dermatomyositis muscle analysis APOC2 STAT3 PANX1 STAT2 HLA-DRB1 MARK1 MYC CD44 STAT1 TFRC ENO3 RELA STAT4 HLA-C HLA-A PMC6567055__F1 Tumor-associated macrophage (TAM) function in the ovarian cancer tumor microenvironment (TME) and examples of therapeutic strategies IL10 CCL22 CCL18 SIRPA CCL2 CD47 PMC8786484__F6 Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology CDA APP PMC11815730__F3 Hippo signaling pathway components in mammals LATS1 LATS2 YAP1 TEAD4 PMC3815562__F1 Outline of steps mediating androgen synthesis and metabolism in prostate cancer cells STAR HSD17B6 CYP17A1 HSD3B1 AKR1C2 AKR1C1 UGT2B17 PMC4490529__F7 Schematic model of DMF-induced neuroprotection in rat NPCs and differentiated neurons HEL-S-22 FTH1 NQO1 SRXN1 PMC5528384__F7 Cyclophosphamide (CTX)‐mediated immunomodulation on the basis of genes up‐regulated by treatment SYK BCL10 CXCL2 SRC CARD9 PMC3033602__F1 Adapted from KEGG colorectal cancer pathway [, , ] BAX CASP9 SMAD2 APC SMAD4 FOS PMC8485019__F1 Bile reflux and hypopharyngeal cancer STAT3 BCL2L1 IL10 EGFR IL6 IL1B PMC3662247__F6 PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity HMGB1 TIRAP TLR4 CD14 IRF3 TRAF6 MYD88 PMC9600942__F5 Tumor-Infiltrating Dendritic Cells: Decisive Roles in Cancer Immunosurveillance, Immunoediting, and Tumor T Cell Tolerance CSF1 IDO1 FOXP3 CCL2 PMC11840835__F3 Diagram of mechanisms of glucose controlling the fate of blastocyst CDX2 TFAP2C MTOR YAP1 TEAD4 PMC7062300__F2 MS identification, quantification and analysis of protein meK modifications in human platelets CEP290 SMG1 ETFB TLK2 DBT SLC39A2 MARCKS PPP2R5E HNRPR PPFIA2 STAT1 PPM1K INF2 TRIM37 WASHC5 ITK SMC2 SPTBN5 CAP1 MRPL10 NUP85 UBE2U PLGRKT EIF4G1 QRICH2 ME2 KIF21A CALM1 LAMB2 EEF2 MRPL32 EPPK1 HEL-S-64p RNPS1 ZFC3H1 RPP40 RAB10 CMSS1 TP53BP2 PAXIP1 PPP3R1 POLR3A ADNP HEL-S-100n IGF2R GIPC2 SFRS8 CTPS1 HEL-S-108 ANKRD11 SCA7 HEL-S-15 DOCK8 HEL-S-7a ANXA6 EIF1AX ZNF148 SCAF11 EIF2S3 SYNE1 EEA1 ALMS1 PDE3B TNS3 TRIM25 VPS41 SPTBN4 LCK PMC7407354__F1 Scheme of the amino acid (AA)-related energy metabolic pathway shows the amino acids and their metabolites in the nontumor and tumor regions PCK2 GLS PC PCK1 PMC4037996__F2 Role of normal and mutated KRAS protein in the regulation of the signalling pathway associated with EGFR activation EGF EGFR KRAS PMC4037996__F1 Intracellular signalling pathway originating at EGFR and inducing the activation of proliferation, inhibition of apoptosis, and differentiation of epithelial and cancer cells MAPK1 EGF JUN TGFA EGFR PTEN MTOR MYC FOS PMC2193492__F1 Pathways initiating transcription from pIV of the CIITA gene STAT1 MHC2TA USF1 PMC6105527__F2 Cut loose and run: The complex role of ADAM proteases during neural crest cell development ERBB3 C6 TFAP2A ERBB2 MYC CCND1 PMC7598701__F10 Differentially expressed genes involved in the p53 signaling pathway were annotated by KEGG RFWD2 CASP9 ATR SIAH1 AIFM2 PERP CDK2 ATM PTEN PIGS MDM2 MYC PMC5016207__F2 Factors involved in the ontogeny of fetal Leydig cells HGF DHH TGFBR3 KIT ARX CRHR1 WT1 SF1 IGF1 SI AMHR2 AMH GATA4 PMC7898445__F8 Signalling pathway of Eno-RPSA induced the loss of BBB integrity HSPD1 RPSA TLR4 EIF4E PMC9407997__F2 Genetic Variants Associated with Elevated Plasma Ceramides in Individuals with Metabolic Syndrome CERS3 ASAH2 CERS5 SPTLC2 SGMS1 SPTLC3 CERS2 SGMS2 SMPD2 PMC7917224__F8 Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload GSK3B GATA4 PMC5310224__F3 The unfolded protein response in immunity and inflammation TLR4 GSK3B ATF4 TRAF6 TNF IL1B PMC5856749__F5 NRF2-mediated oxidative stress response –signaling in the nucleus JUN AOX1 HEL-S-107 PPIB USP14 PROX1 GPX2 FTH1 FTL MAF CLPP ATF4 UBB PMC6858307__F1 MDC1 loss causes greater IR sensitivity than H2AX loss RAD50 RNF168 H2AX RNF8 ATM MDC1 PMC7775612__F2 Cell signaling pathways activated in acute inflammation induced by carbon nanotubes (CNTs) SYK IL1R1 NLRP3 IL1B PMC6650359__F6 Proposed pathway for the role of OLA1 in ANG II-induced cardiac hypertrophy NPPA MYH7 GSK3B CTNNB1 PMC11677578__F11 Arachidonic acid metabolism pathway MAX DIO1 PTGES3 PC HEL-S-25 PTGES PMC3819050__F2 Wnt7a signals bi-directionally at vertebrate synapses DVL1 WNT7A PMC7232598__F4 Ingenuity Pathway Analysis (IPA) network diagram of differentially expressed genes in patient vs HEL164 PPM1D NEK2 NOTCH2 FANCG UBLCP1 TMEM126A PNP VPS50 HEL-S-68p PAIP2 CDKN3 S100A12 USP16 PMC9641390__F3 Targetable vulnerability of deregulated FOXM1/PLK1 signaling axis in diffuse large B cell lymphoma CDC2 STAT3 MSH6 ATR MSH2 AXL PCNA SOX2 IGFBP2 PLK1 TFAM FOXM1 EEF2K RICTOR IGFBP5 ATM MDM2 NOTCH3 CXCR4 CCNB1 TTF1 HES1 PMC4408853__F1 Neuronal Ca2+signalling toolkit STIM2 ORAI1 STIM1 PMC11677578__F10 Autophagy–animal pathway MAX TSC2 TP53INP2 HEL-S-130P CTSL PTEN MTOR INS PMC7716168__F6 The role of MOB1A in the survival of GBC cells under glucose-deprivation conditions MOB1A STAT3 IL6 PMC4069059__F7 Receptor Interactive Protein Kinase 3 Promotes Cisplatin-Triggered Necrosis in Apoptosis-Resistant Esophageal Squamous Cell Carcinoma Cells RIPK3 CASP9 JUN MLKL CASP3 RIPK1 PMC3928158__F1 Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells CD74 NOD2 CD46 HEL-S-28 MYC PMC8100412__F9 Integrated Molecular Docking with Network Pharmacology to Reveal the Molecular Mechanism of Simiao Powder in the Treatment of Acute Gouty Arthritis TH SF1 TRADD MAF SI TAL2 PMC7070171__F8 Schema showing the major roles of butyrate in inhibiting atherosclerosis of mice in this study VNN1 ABCG1 SP1 SLC2A4 CYP7A1 PLIN5 ADFP GCK PREB PMC5227296__F4 Cordycepin function in chondrogenesis and chondrocyte hypertrophy of MSCs ID2 NOTCH2 NOTCH1 PMC3064890__F5 BRCA2/RAD51 pathway in the response to stalled forks ATR ATRIP EMSY PCNA BRCA2 ATM PMC3064890__F4 BRCA2/RAD51 pathway in response to DSBs ATR ATRIP EMSY BRCA2 ATM HP PMC3540089__F1 PORPHOBILINOGEN DEAMINASE Deficiency Alters Vegetative and Reproductive Development and Causes Lesions in Arabidopsis CPO UROD UROS PMC7068849__F4 Regulation/function of IL-17 secreting cells during candidiasis APC IL1B CARD9 PMC3412625__F6 Combination therapy with VELCADE and tPA is neuroprotective in aged rats after stroke and targets miRNA-146a and the toll-like receptor signaling pathway TLR4 IRAK1 MMP9 PMC8316858__F8 Investigating the Pharmacological Mechanisms of SheXiang XinTongNing Against Coronary Heart Disease Based on Network Pharmacology and Experimental Evaluation BAX CASP9 BAD CASP3 PMC4249809__F1 Role of TGF-beta in healthy and OA cartilage TGFBR2 SMAD1 DKFZp781O1323 SOX9 SMAD2 PMC6719163__F6 Nobiletin-induced apoptotic pathway in bladder cancer cells BAX HEL-S-99n BAD ATF4 MTOR EIF2A PMC4040287__F4 SIRT1 in neurodevelopment and brain senescence RARB ROCK1 HSF1 ADAM10 BDNF SIRT1 PMC9138898__F1 Controlling Cancer Cell Death Types to Optimize Anti-Tumor Immunity BAX CASP9 CASP8 CASP3 PMC4974939__F3 Activation of “RNA-sensing” TLRs on neurons and microglia triggers distinct effects TLR3 IL16 TLR7 TNF PMC7150781__F3 HBV suppression of type I interferon (IFN) response (Green arrows indicate the related signaling pathways and T-arrows in red indicate blocking the targets) TBK1 MAVS TLR3 STAT2 IRF9 IRF3 OAS1 PMC7868824__F8 Overall, pyrazole significantly up-regulate E-cadherin expression and regulated MMP-2 expression in A549 cells TLR4 EGFR PMC6523735__F6 Proposed model for miR-130a downregulation of HCV infection ATG12 ATG5 PKLR PMC10308132__F1 Targeting SAMHD1: To overcome multiple anti-cancer drugs resistance in hematological malignancies CGAS IRF3 IRF7 CCNA2 TRAF6 PMC11799893__F3 Transcriptome analysis of isopentanol synthesis pathways F2 PDC MPC1 MPC2 PMC5599481__F4 Overview of arachidonic acid cascade associated with inflammatory pain response LTB LTA COX1 PMC5842623__F1 Mammalian target of rapamycin (mTOR) signaling pathway SLC3A2 STK11 CAB39 DDIT4 GSK3B BRAF TTI1 PTEN FLCN MTOR SKP2 PRR5 GRB10 INSR PDPK1 NRAS CHUK AKT1S1 RPTOR RPS6 EIF4B SGK1 ARHA TNF DEPTOR IRS1 EIF4E RHEB MLST8 RICTOR IGF1 IKBKB NPRL2 LPIN1 GRB2 RNF152 PMC5684300__F2 Simplified diagram depicting canonical and non canonical Beta-catenin signalling pathways in bone APC ROR2 PTH RUNX2 CTNNB1 PMC2852112__F2 Anti-viral and pro-viral functions of autophagy ATG12 TLR7 EIF2A ATG5 PMC2852112__F1 Scheme of the autophagy pathway ATG10 ATG3 ATG12 ATG14 MTOR ATG5 PMC7701249__F2 Iron metabolism-related pathway in ferroptosis TF PMC9059101__F11 Critical and Diverse Roles of CD4–CD8– Double Negative T Cells in Nonalcoholic Fatty Liver Disease CD36 IL17A PMC5778882__F1 The Axl signaling pathway STAT3 AXL GRB2 SRC ELMO2 PMC11599216__F4 Crossroads of epigenetics and immune pathways TET2 KDM5B EZH2 PHF2 KDM5C IRF3 METTL3 TRAF6 MYD88 PMC5333072__F1 MNT and its place in the MAX-MLX network of interacting proteins MAX MGA MXD1 MXD4 MNT MLX MXD3 MYCL MYC MLXIP PMC5495965__F2 Predicted interactions among proteins encoded by genes expressed differentially in late proestrus TH NTS SLC17A6 GAL ADORA2A CCK AVPR1A PGR SLC32A1 OPRM1 UCP2 ABAT KISS1 GHSR SORT1 SLC18A2 CNR1 EPHA3 GRIA4 PMC4698356__F2 Proteins highlighted for their contributions to molecular regulation in diabetes and heart failure OGA SP1 STIM1 PMC3345192__F1A MYC on the Path to Cancer MAX GSK3B MYC CTNNB1 PMC7850464__F1 B7-H1/PD-1 signaling pathway in osteosarcoma STAT3 APC PTEN HDAC6 PMC2916838__F8 NPRL2 Sensitizes Human Non-Small Cell Lung Cancer (NSCLC) Cells to Cisplatin Treatment by Regulating Key Components in the DNA Repair Pathway NPRL2 ATM PMC7035145__F13 Schematic showing integration of inputs in the SIP syncytium VIP PDGFRA PMC8224368__F2 Combined Single Nucleotide Variants of ORAI1 and BLK in a Child with Refractory Kawasaki Disease BLK CD40 SYK CASP3 ITPKC FCGR2A PMC8998982__F2 Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response MAX SLC3A2 AURKA BRD4 ATR CAD HK2 EGFR MCL1 PLK1 MYC SAE1 CDK12 PES1 AURKB SLC25A6 SLC1A4 ATF4 HEL-S-87p PFAS CDK9 PMC8998982__F1 Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response PCNA CDC6 WRN CDT1 MYC MCM7 CDK6 CCND2 CDC45 MCM3 CDK2 MCM5 MCM6 MCM2 POLE CDK4 PMC5006314__F7 Inhibitory effect of NBL1 on PDGF-BB-induced human PASMC proliferation through blockade of PDGFBeta-p38MAPK pathway CCND1 NBL1 CDK4 PMC3170700__F1 Activation of cellular responses during ER stress SELL ATF4 EIF2A PMC6770886__F2 Rac3-mediated mechanisms in cancer SHD VAV2 ARF6 RAC3 PMC7074533__F3 The vascular smooth muscle contraction pathway MYLK2 NPPC CALD1 PLCB4 ADORA2A RAMP2 RAF1 ADRA1A PLA2G1B CALML4 PLA2G2E MAPK3 GNAS MYLK ACTA2 PRKCE ADCY9 GUCY1A2 ROCK1 PRKCA KCNMA1 CACNA1S RAMP3 EDN3 ROCK2 ADM ARHA ARAF NPPA EDN1 EDNRA GNA11 CALM1 NPR2 MAP2K2 CALCA ACTG2 NPPB PTGIR PRKG1 AVP PMC5520734__F7 Schematic diagram of G0/G1 phase arrest and ROS-dependent MAPKs pathway in which furanodienone induces cell growth inhibition and cell death in CRC cells BAX CASP9 CASP8 CDK6 CCND1 CDK4 PMC6211194__F2 Simplified metabolic pathway of ∆9-tetrahydrocannabinol (THC), or ∆1-tetrahydrocannabinol, under the monoterpenoid naming system, in humans UGT1A1 UGT1A3 UGT1A9 UGT1A10 CYP2C9 CYP3A4 PMC5549626__F2 PLCG1 deficiency perturbs phosphorylation on canonical TCR signaling proteins CDC42 JUN PLCG1 BCL10 PLCG2 CD36 LAT ITK VAV1 REL FOS LCK PMC5587804__F4 Differential metaMIR analysis recovers miRNAs involved in cancer BMPR2 SMAD1 TGFB1 BMPR1A SMAD2 SMAD4 BMP7 TGFBR3 PTEN MYC TGFBR1 TGFBR2 FOXD3 NF1 CHD5 NOG BMP4 BMP2 NF2 PMC6049516__F1 Altered Hippo pathway signaling contributes to the kidney cystogenesis in Pkd1 mutant ADPKD PKD1 ARHA PMC9580211__F8 CapG promoted nasopharyngeal carcinoma cell motility involving Rho motility pathway independent of ROCK HEL-S-66 RHO RAC1 PMC8511707__F1 Fatty Acids Derivatives From Eukaryotic Microalgae, Pathways and Potential Applications FAS tmp_locus_29 HEL-S-5 PMC4788885__F5 Wnt signaling pathway RBX1 SIAH1 ROCK2 APC CER1 SMAD4 SKP1 ARHA NLK DAAM1 PMC11512478__F8 Mechanism of CHRDL1-MED29-mediated interruption of EMT evolution in OSCC CDH2 MED29 CHRDL1 UNK PMC4144918__F1 Do Mantle Cell Lymphomas have an “Achilles Heel”? CD40 BAX SYK MCL1 RELB MTOR TRAF3 MDM4 BTK CDK6 BCR BCL2 ATM LYN MDM2 TRAF2 CDK4 PMC3843232__F1 Causal role for JAK2 V617F in thrombosis MPL TPO PMC6611921__F4 Pathway map based on renal age-associated gene (RAAGs).Enriched molecular pathways based on the set of 634 RAAGs are displayed EGF HEL-S-62p MTOR CXCL6 TNF TNFRSF11B PMC6073901__F2 Proposed model for a signaling network between Notch, HIF-1A, and GPER in cancer epithelial-mesenchymal-transition (EMT) LOX NOTCH1 PMC8924146__F4 MicroRNAs as a clue to overcome breast cancer treatment resistance EREG EGFR PTEN IGF1R ERG MTOR PMC3979163__F1 The canonical Wnt signaling pathway APC GSK3B RHO CTNNB1 PMC8093869__F1 Neuroinflammation in HIV-Related Neuropathic Pain FZD2 CX3CR1 ROR2 CASP3 PC CXCR4 PMC4424147__F1 Receptor-mediated activation of PI3K-Akt pathway and signaling RHEB BAX SYK BAD TSC1 BCR PHLPP2 FOXO3A GSK3B PTEN LYN MTOR PMC6325856__F10 The proposed cardioprotective mechanism of mAb A treatment in hearts following a myocardial infarction KLF15 GSK3B MTOR PMC6692500__F5 Sodium and potassium loci in behavior, thermoregulation, and weight loss networks HEL-S-117 CYP2A6 PKHD1 HTR4 FGF21 MLXIPL PPP3R1 PLCL1 NEGR1 NRXN3 LRRN2 TMEM107 BRINP1 CHST10 RARB SCN2A ADRA2C AHR FNDC4 BDNF PMC9616118__F9 Meritorious integrated medical regimen for hepatic fibrosis and its complications via the systematic review and meta-analysis for Dahuang Zhechong pill-based therapy BAMBI SHH SMO MYD88 PMC3520542__F13 Molecular mechanism for Elovl5 control of mTORC2, FoxO1-S256 phosphorylation, and hepatic GNG ELOVL2 RICTOR FASN FADS2 ELOVL5 ELOVL6 PCK1 FADS1 PMC7905058__F3 Gain-of-function of mutant p53 over proliferation, invasion and metastasis SENP1 DAB2IP HNRNPK RAC1 PMC5977062__F1 Diverse regulatory mechanisms of ncRNAs on Wnt signaling pathway APC LRP5 LRP6 CTNNB1 PMC5542021__F1 Signaling pathways for selected transcripts that regulate dendritic spine density CDC42 CDH2 HEL-S-47e PAK1 ARHA CDC42EP4 CDC42EP3 PMC406534__F1 Proteolytic processing of APP is divided into an amyloidogenic and an antiamyloidogenic pathway BACE1 APP ADAM10 PMC9563036__F3 Emerging Role of Pericyte-Derived Extracellular Vesicles in Vascular and Neurological Health IQGAP1 RAC1 PMC9563036__F4 Emerging Role of Pericyte-Derived Extracellular Vesicles in Vascular and Neurological Health BAX NGF BCL2 BDNF PMC7351826__F7 Hypothesis that Sal B protects myocardium through inhibiting the expression of HMGB1 via activating PI3k/Akt signalling pathway in myocardial I/R injury BAX HMGB1 TLR4 PMC11635239__F8 LPS induces the upregulation of activin-A in recAMs, which can drive the EMT process by activating the TGF-Beta-SMAD signaling axis INHBA SMAD2 PMC3275780__F2 T cell activation ZAP70 APC SRC PMC6319725__F10 Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells CSA2 NAMPT PMC10905894__F4 Molecular mechanism of resveratrol promoting differentiation of preosteoblastic MC3T3-E1 cells based on network pharmacology and experimental validation HTRA2 CASP9 CASP6 CAD CASP2 CASP12 ATM TNF HRK TRAF2 DIABLO FADD PMC7849651__F6 Summary of the potential pathways about exogenous antigen 11S processing and presentation in the distal intestine RHEB TSC2 CDA AEBP2 C2 AIP RHO MTOR PMC9563451__F2 Colorectal Cancer and Purinergic Signalling: An Overview PANX1 ADA PMC7071425__F9 Elav1 pathway for mRNA stabilization NUP214 PRKCA SET YWHAZ PMC3246369__F2 Small RNAs in transcriptional gene silencing and genome defence CHP2 AGO1 CHP1 ARC PMC5739664__F7 Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling CORT TBK1 MAVS IRF3 PMC8431321__F2 Interplay between Hepatitis E Virus and Host Cell Pattern Recognition Receptors TMEM134 TBK1 MAVS TLR3 TLR4 SIRPA IRF3 TLR7 MYD88 PMC12015515__F1 Novel signaling pathway linking IL18 proteolytic processing to anticancer immunity CDK8 STAT1 IL18R1 CASP3 ISG15 PMC9052234__F2 Cytokines in Abdominal Aortic Aneurysm: Master Regulators With Clinical Application TGFBR2 IL13 CCR5 PDGFA CCR2 IL33 IL8RB CXCL10 CXCR4 IL6R IL1B TGFBR1 PMC8358715__F2 Hypoxia‐inducible factor‐1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseases AHR STAT4 FOXP3 PMC3417165__F1 PI3K/AKT signaling pathway in Tregs RHEB TSC2 TSC1 PTEN FOXP3 PMC8875876__F4 Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression TPH1 KYNU KMO TPH2 PMC8124456__F1 CD26/DPP-4: Type 2 Diabetes Drug Target with Potential Influence on Cancer Biology CXCL12 DPP4 MTOR CXCR4 PMC3215886__F2 The “inhibitory” pathway of WNK4 WNK1 WNK4 WNK3 PMC7313089__F2 Involvement of ubiquitin in the key signaling pathways important for IFN production and IFN responses TBK1 CGAS CGA MAVS TANK IRF3 PMC6510543__F1 A sugar rush for innate immunity TIFA TRAF6 ALPK1 PMC8746116__F6 Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic A‐ and B‐cells CYP2R1 SLC35A2 GSTM3 GSTA4 KEAP1 GCLM NQO1 GCLC NFE2L2 SQSTM1 PMC3104579__F1 RhoA/ROCK I pathway and remodeling of microtubule network underlie the polarization and migration of HSPCs CD44 ICAM3 MSC ARHA CXCR4 CD34 PMC195990__F5 A model of Hip1's role in lung branching morphogenesis SHH FGF10 PMC12234736__F5 LLPS regulates immune cell alterations during adaptive immunity BCR LAT GRB2 PMC12234736__F4 Phase separation is associated with cGAS-related inflammation TBK1 CGAS MAVS TRIM25 IRF3 IRF7 TREX1 PMC12234736__F3 Sufu prevents sepsis by disrupting the LLPS of TRAF6 SUFU TLR4 IRAK1 TRAF6 IRAK4 MYD88 PMC9573972__F1 Unraveling the mechanobiology of cornea: From bench side to the clinic TGFBI SOX9 BMP4 RHO ABCG2 MYC CTNNB1 PMC4480706__F8 HDAC9 promotes glioblastoma growth via TAZ-mediated EGFR pathway activation EGFR CDK2 HDAC9 PMC6107301__F8 The conversion of a T:G mispair to a T:A mutation by guanine oxidation followed by long-patch base excision repair MPG APC PMC2890409__F1 Classification of Dengue Fever Patients Based on Gene Expression Data Using Support Vector Machines RIGI TLR3 TLR9 IRF3 IRF7 TLR7 MYD88 PMC4551447__F1 Decade in Review-Kidney Cancer Kidney cancer's decade—discoveries, therapies and opportunities TSC2 BAP1 PTEN SETD2 VHL SMARCA4 PMC3653146__F1 Possible signal pathway activated by cathelicidin (LL-37) to inhibit cell proliferation in gastric cancer cells CCNE2 SMAD1 DKFZp781O1323 CDK2 PMC7393681__F2 More RAS vulnerabilities, downstream MTOR MYC CDK9 PMC8709003__F3 Inflammatory Effects of Bothrops Phospholipases A2: Mechanisms Involved in Biosynthesis of Lipid Mediators and Lipid Accumulation COX1 MYD88 PMC11174838__F3 Resistance Exercise and Essential Amino Acid Intake on Muscle Quality, Myokine, and Inflammation Factors in Young Adult Males MTOR TNF PMC11763651__F1 Biosynthesis of BH4 and genetic diseases due to BH4 deficiency TH DHFR PMC3618895__F4 Significantly changing expression sub-networks in LMB hypothalamus TH TGFB1 HOMER1 KLKB1 GAD1 GH1 KRAS FOS SLC12A2 PCK2 SYT7 PVALB DRD1 DRD2 GNRHR PRL SENP1 NR3A2 POMC NFKBIA NPY EP300 PROC AMACR PMC4152244__F1 Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma TSC2 STK11 TSC1 BNIP3 HIF1A MTOR VEGFA PMC4575550__F1 Effects of exercise on the signalling pathways associated with muscle growth and wasting in sarcopenia and cachexia IGF1 SMAD2 MTOR PMC5841108__F11 Schematic representation of miR-34a regulating SIRT1/AMPKA signaling pathways and Egr1 involved in the HG-induced fibrosis and inflammation in RMCs EGR1 CXCL5 SIRT1 PMC12152632__F11 Proposed mechanism of TX's neuroprotection against Mn toxicity by upregulating REST expression via Wnt/Beta-catenin signaling in CAD neurons REST WNT3A GPER LRP5 LRP6 PMC3621754__F3 MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches EGFR FGFR3 GRB2 MTOR SRC PMC4008387__F2 Molecular mechanisms of hepcidin regulation STAT3 BMP6 SMAD1 TFR2 DKFZp781O1323 GDF15 SMAD4 EPO HAMP FURIN TMPRSS6 HFE2 PMC4278318__F1 NMI and EMT NMI STAT1 JAK1 PMC3621754__F6 MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches STAT3 STAT1 TRADD RELA MUC1 TRAF2 PMC3621754__F5 MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches TCF7L2 EGFR SRC CCND1 CTNNB1 PMC8143046__F2 Interplay of Glucagon-Like Peptide-1 Receptor Trafficking and Signalling in Pancreatic Beta Cells APPL1 ECE1 SNX1 SNX27 PMC5881178__F4 Metabolomic differences associated with Wnt1-initiated tumors LOX CDO1 WNT1 PMC8911130__F1 An Assessment of Selected Molecular and Biochemical Markers of the Folate Pathway as Potential Risk Factors for Fetal Trisomy 21 during the First Trimester of Pregnancy in the Polish Population MTRR TYMS MTR PMC7923226__F2 Main molecular mechanism of actions deployed by the anticancer peptides presented in this review BAX CASP9 CASP3 FADD PMC8046990__F9 NAD+-SIRT1 signaling fine-tunes the activity of key transcription factor networks to promote adipocyte function NDUFB8 NDUFB6 NDUFB5 NMNAT1 CXCL1 NMNAT2 LAMC1 CXCL10 GSTA3 COL6A1 IL1RN NDUFA3 MMP3 NDUFB3 LAMA4 LCN2 SIRT1 PMC3494243__F2 Pathways for C18 PUFA conversion to C20–22 PUFA synthesis FADS2 ELOVL5 FADS1 PMC3680926__F1 Estrogen receptor functional domains and signal transduction schemes TF PMC3008616__F1 EGFR pathway and its main downstream effectors (top) EGFR BRAF PTEN KRAS PMC9250793__F1 Signaling pathways in hair follicle stem cells APC LRP5 LRP6 CTNNB1 PMC5535855__F3 Schematic diagram showing the pathological cardiac functions of ANKRD1 in relation to hypertrophy, fibrosis and apoptosis BAX ANKRD1 KIF6 LOXL1 PLG SCX GATA4 IGFBP6 NCL PMC7396149__F4 Immunosuppressive drugs for corneal transplantation and their sites of action in the immune system CD40 CD80 APC CS CTLA4 MTOR PMC9250793__F4 Signaling pathways in hair follicle stem cells SUFU SMO GLI3 PMC7769953__F1 IL-6 signaling pathway and inhibitory agents STAT3 IL6 SRC PMC5628484__F6 Regulatory roles of differentially expressed genes involved in the MAPK signaling pathway (a, map04010) and pathways in cancer (b, map05200) MAX ECSIT JUND FAS RAF1 EGFR TNF TRAF6 FLNA MOS PIR GRB2 POLE TRAF2 PMC11048686__F1 Vitamin D synthesis pathway NR1i1 CYP2R1 CYP27B1 DBP CYP24A1 CYP27A1 PMC4383680__F10 G-protein independent coupling of the MC4R to Kir 7.1 in hypothalamic neurons POMC MC4R NPY AgRP PMC6314014__F2 Top network of metastasis virulence biomarkers (Ingenuity Pathway Analysis Knowledge Base) HMFT1766 AEBP1 HSPG2 TIMP1 FSTL1 LOXL1 NRP1 SPSB1 CTSK PCOLCE NAMPT NID1 SCARF2 CX3CR1 FCGRT GJA1 PMC6314014__F1 Top network depicting the influence of high fat diet on mammary tumor gene expression (Ingenuity Pathway Analysis Knowledge Base) GATA5 DDX5 MAPK13 HEL-S-133P SPHK1 PTEN MAPKAPK5 FGF10 TNF HBA2 PABPC1 EIF4G1 EIF3E AGER PRKDC SAA2 COL4A2 CASP3 GATA6 HBB PMC5350105__F1 M1 macrophage metabolism ACLY FAS CIC CAD HEL-S-133P ME1 AASS PMC11484340__F3 Cross-inhibition between the PI3K/AKT/mTOR and RAF/MEK/ERK pathways TSC2 BAD TSC1 PTEN MDM2 PMC3751038__F2 T-cell death during HIV-1 infection BAX FAS CXCR4 FADD PMC6523474__F2 Acute phase response (APR) is central to the FL induced response in skin, brain, and liver of all three model organisms ECSIT FLT3 HMGB1 TREM1 OSM HEL111 HEL-S-28 HAMP MIF MTOR POR TEC CNTF NGF HP CXCR4 PMC7981903__F3 Role of GRP78 in cellular apoptosis ATF4 EIF2A TRAF2 PMC3408740__F1 Alarmins: awaiting a clinical response HMGB1 S100A8 S100A9 IL1B PMC3700945__F5 Pathway detail for the IPN: Mucus Hypersecretion model.Notes: The Mucus Hypersecretion model contains signaling detail from four main pathways known to induce airway MUC5AC production SP1 IL13 TNF PMC4458296__F1 Purine metabolic pathway PNP ASL AMPD1 XDH ADA PMC4199871__F2 WNT Signaling in Bone Development and Homeostasis SOST DKK1 APC LRP5 LRP6 WIF1 CTNNB1 PMC5310224__F5 Unfolded protein response in immunity and inflammation ATF5 NLRP3 TXNIP ATF4 TNF XBP1 IL1B PMC7266379__F1 Loss of MAP3K7 sensitizes prostate cancer cells to CDK1/2 inhibition and DNA damage by disrupting homologous recombination SLC25A5 AURKA SIRT7 PSMB6 PSMD12 TYMS MYC HEL-S-51e PLK1 DHODH SMPD4 BIRC5 PSENEN MTTP SHMT1 A2M F8 FDX1 PARP2 CPT2 POLE PSME2 HDAC2 DHPS MTFMT HINT1 RAD51 POLE2 PSMB3 IMPDH1 TUBG1 TUBB PSMD13 MLST8 POLE4 POLA2 ATP2C1 PSMC6 AURKB POLE3 MAP3K7 CDK2 TUBD1 PPIF VAMP2 IKBKE DHFR CENPE PNP PIG59 CHEK2 HABP2 CHUK APP HPRT1 TOP2A PSMC3IP CDK4 CDC2 CRYZ KIF11 RRM1 RRM2 CTH SEPSECS HEL-S-70p HDAC1 NR1C1 MTHFD1 PSMD9 RPS6KB1 SLC25A6 CHEK1 TPP2 CPT1A PMC4265444__F5 The sulfur assimilation pathway and the genes encoding the enzymes of the different biosynthetic steps GPX2 MT3 GPX1 PMC8918735__F8 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia BAD FAS GEM PMC6324535__F7 Working model CDK6 CDK4 CTNNB1 PMC8918735__F7 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia BAD FAS GEM PMC4422099__F2 Targeting TRAF3 Downstream Signaling Pathways in B cell Neoplasms PHB2 MCC TRAF3 PARP1 PMC8918735__F4 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia POR HPD TH ATM APP ACD HIRA PMC8918735__F3 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia SELE KL PMC2586109__F1 Protein kinase C isozymes as therapeutic targets for treatment of human cancers APC GSK3B RAC1 CTNNB1 PMC9091963__F1 Insights Into Vascular Anomalies, Cancer, and Fibroproliferative Conditions: The Role of Stem Cells and the Renin-Angiotensin System ATR COX2 CTNNB1 PMC5536362__F8 G protein-coupled receptor kinase 2 promotes cardiac hypertrophy ADRBK1 GSK3B HPRT1 PMC3578734__F1 Scheme of CML hematopoietic stem cell signaling pathways in which predicted targets of microRNAs associated with CML are involved BAD CBL SMAD4 MDM2 GRB2 MYC GAB2 TGFBR1 PMC5458280__F3 Carboplatin-induced hematotoxicity among patients with non-small cell lung cancer: Analysis on clinical adverse events and drug-gene interactions SRI CD59 CD2 CD36 IL3 ELL CD7 CD14 CD22 EPO CD19 TNF CD34 CD44 CD24 EPOR CD37 CD9 CD33 TPO PMC3539548__F1 Host cell machinery gets activated during influenza infection and leads to trigger Signaling pathways F2 ATF2 EIF2A PMC9091963__F8 Insights Into Vascular Anomalies, Cancer, and Fibroproliferative Conditions: The Role of Stem Cells and the Renin-Angiotensin System COX2 CTNNB1 PMC4829957__F3 Targeting EPO and EPO RECEPTOR PATHWAYS in Anemia and Dysregulated Erythropoiesis ERFE PTPN18 EPOR EPO PTPN11 PTPN6 PMC9091963__F9 Insights Into Vascular Anomalies, Cancer, and Fibroproliferative Conditions: The Role of Stem Cells and the Renin-Angiotensin System NR1i1 SELL PMC4327877__F8 TGF-Alpha-IL-1A/Beta-IL-1ra autocrine cascade contributes to TNF-induced hepatocyte proliferation and Adv-infection sensitized apoptosis through the regulation of multiple shared signaling pathways TGFA EGFR TNF PMC7835526__F3 Interplay of IGF-1R-related signaling and niche microenvironment in stemness expressions of different cell types SOX2 HRG IGF1R MTOR CCL5 HEL-S-70p IGF2 IL6R IGF1 MSC ERBB2 GSC CXCR4 PMC4588066__F1 Regulation of oocyte maturation CDC2 MOS APC WEE1 GPR3 MYT1 PMC10985098__F3 Skeletal interoception in the aberrant subchondral bone remodeling of OA MSC NPY ARC AgRP PMC3021995__F3 Post-transcriptional control of mammalian clock genes PER2 HNRNPD CRY1 PMC8151534__F7 Evidence of Cooperation between Hippo Pathway and RAS Mutation in Thyroid Carcinomas NKD1 RASSF6 ID2 APC GSK3B SOX2 SMAD4 RASSF4 AREG MYC ID1 CTNNB1 LATS1 BIRC5 LATS2 AFP HIPK2 PAK1 GHB2 NF2 BIRC2 CCND1 PMC2680597__F1 Methylobacterium Genome Sequences: A Reference Blueprint to Investigate Microbial Metabolism of C1 Compounds from Natural and Industrial Sources HEL-S-62p HPR C2 PCCA PCCB GCK PMC9106463__F3 PKM2 in the Regulation of Mitochondrial Function: Focus on Mitochondrial Metabolism, Oxidative Stress, Dynamic, and Apoptosis. PKM2 in Mitochondrial Function BAX BCL2 PMC8336005__F4 Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions NKD1 SFRP5 FZD2 NKD2 PYGO2 LRP5 MYF5 LRP6 RUNX2 SFRP1 CTNNB1 PYGO1 WLS SOX6 FZD8 SFRP4 FZD4 FZD3 SOX9 PORCN FZD1 SOX5 PMC8336005__F3 Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions APC COIL GSK3B LRP5 LRP6 CTNNB1 PMC8155968__F2 Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities IL7R PTEN MTOR CCND1 PMC8155968__F1 Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities BAX ATR BCL2 ATM MTOR PMC9666367__F2 Cellular phenotypic transitions in diabetic nephropathy: An update FGFR1 LRP5 LRP6 SMO ARHA CTNNB1 PMC12084448__F4 Metabolomics study in NENs ACVR2B ACVR2A INHBA SMAD2 SMAD4 FOXA2 PMC7882971__F6 LETM1 down‐regulation‐induced autophagy in CRC cells LETM1 MTOR PMC4867331__F3 Notch and Wnt pathway inhibition by natural products CD44 MAML1 APC MYC PMC8226851__F4 SARS-CoV-2: One Year in the Pandemic. What Have We Learned, the New Vaccine Era and the Threat of SARS-CoV-2 Variants TLR3 IRF9 IRF3 IRF7 TLR7 ACE2 PMC12084448__F2 Lipid metabolism changes in NENs HMGCS1 FABP5 ALKBH5 FASN CYP46A1 IGF2BP2 MTOR CTNNB1 PMC12084448__F1 Metabolic pathways in NENs ACLY ACSS2 TG CD36 FASN MTOR PMC3111669__F2 BMP signaling and its blocking SMAD1 DKFZp781O1323 SMAD6 SMAD4 PMC6536572__F3 Nrf2/ARE pathway during basal and stressed conditions RBX1 NQO1 GSK3B PMC3750636__F1 USP1 Domain structure and summary of the cellular functions of the USP1/UAF1 complex RAD18 FANCD2 PCNA APC USP1 PMC7640403__F4 Amino acid, energy and Wnt signaling to mTORC1 GSK3B HIF1A FLCN MTOR CASTOR1 DEPTOR RHEB MLST8 TSC2 ENG TSC1 FNIP2 CASTOR2 SLC38A9 PMC9376771__F1 Hepatocellular carcinoma and microbiota: Implications for clinical management and treatment TLR4 TAB3 IRAK1 TRAF6 IRAK4 MYD88 PMC7281579__F1 Increased glucose metabolism facilitates endometrial cancer phenotypes ACLY STAT3 OGT HEL-S-133P FOXO1 HK2 FASN PTEN MTOR JAK1 POLE PMC2715501__F1 Study background HSD17B3 CYP11B2 CYP11A1 HSD11B2 HSD17B1 HSD17B2 PMC7489527__F6 Anti-neuroinflammatory effects of Clinacanthus nutans leaf extract on metabolism elucidated through 1H NMR in correlation with cytokines microarray IFNG IL16 IL4 PMC4747705__F6 BRAF(V600E)-directed recruitment of MAFG and its corepressors to CIMP and HIM gene promoters DNMT3B BACH1 MAFG CHD8 PMC3618314__F7 Characterization of CP genes in relation to the canonical TGFB signaling pathway C9 NODAL PMC6614686__F5 Pathway Map of Glioblastoma obtained from Wikipathways using Cytoscape EGFR BRAF PRKCZ PTEN IGF1R CDKN2B PRKCH PRKCB FGFR2 LPA RB1 PLCG1 BTK CDK6 FOXO4 MAP2K4 CCND2 PLCG2 NF1 ERRFI1 ATM SRC CCND1 MAP2K3 IRS1 ARAF SPRY2 TSC2 CBL PRKCI TSC1 CDKN1A BRCA1 FOXO1 CDKN1B PDGFRA ERBB2 CDK2 EP300 MAP2K5 GRB2 PMC6928836__F1 A schematic illustration of unfolded protein response (UPR) and the effects of salicylic acid (SA) under stress condition in plants SAG CS PMC6563011__F2 Schematic view of PKCA inhibitory activity on the Wnt/Beta-catenin signaling pathway in the normal colon epithelium and in colon cancer APC GSK3B PC FAP CTNNB1 PMC3192911__F2 Therapeutic tol-DC in organ allotransplantationTol DC can be either recipient- or donor-derived (in the case of living-donor transplantation) HLA-G APC FOXP3 PMC7719100__F2 Molecular mechanism of adipogenesis SMAD1 BMP4 CTNNB1 PMC8336005__F5 Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions SFRP5 TCF7L2 APC GSK3B LRP5 ZNRF3 LRP6 RSPO3 CTNNB1 PMC8267940__F4 Instruction of Immunometabolism by Adipose Tissue: Implications for Cancer Progression FAS ARG1 MTOR PMC6196292__F4 The proposed mechanisms of NEAT1 action in cancer STAT3 EGFR EZH2 PMC8801219__F8 Ecballium elaterium attenuates neuroinflammation in an animal model of Alzheimer’s disease through modulation of nuclear factor KB pathway TRADD TNF IL1B MYD88 PMC7589120__F1 Pathway connecting lipid synthesis, lysosomes dysfunction and iron accumulation in NBIA syndromes WDR45 DCAF17 PANK2 FTL PLA2G6 C19orf12 CP COASY PMC6832112__F1 RTK and nRTK networks in H STAT3 EGFR MMP2 ADAM10 GRB2 MMP9 PMC9385341__F2 From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease SLC3A2 LOX GPX4 LPCAT3 PMC11466420__F8 Graphical overview of the effect of BA treatment on porcine oocyte maturation KEAP1 GPX1 HEL-S-44 PMC5609982__F10 Anti-proliferation of triple-negative breast cancer cells with physagulide P: ROS/JNK signaling pathway induces apoptosis and autophagic cell death BAX CCNB1 PMC4051344__F1A Regulation of Inflammation in Cancer by Eicosanoids LTB LTA LOX COX1 PMC3132189__F4 Proposed lipid metabolic pathways in Giardia PGP PALM PC PMC4169646__F7 Prolyl-Hydroxylase Inhibitor, Ethyl-3,4-Dihydroxybenzoate, Induces Cell Autophagy and Apoptosis in Esophageal Squamous Cell Carcinoma Cells via Up-Regulation of BNIP3 and N-myc Downstream-Regulated Gene-1 BAX BNIP3 BCL2 PMC3190890__F7 The signaling pathway of EpCAM complex proteins in the regulation and enhancement of OSKM-mediated pluripotency reprogramming CLDN7 EPCAM ADAM17 PSEN2 SOX2 PMC4356243__F5 Advances in therapeutic development for spinal muscular atrophy EGF EGFR SMN1 GRB2 BDNF PMC4673535__F4 Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis CXCL9 CXCL16 ABCG2 AQP8 PMC4825819__F5 Coordinating muscle-specific gene expression with cell cycle exit CDK6 CDK2 GDA CDK4 PMC9448575__F3 Crosstalk between Oxidative Stress and Exosomes EGFR PMC3375988__F7 Schematic representation of the proposed roles of oleosin LPA PC PMC5410396__F2 Promiscuity of PLP enzymes involved in H2S synthesis PMC9202199__F9 Power of heteronemin in cancers STAT3 BAD PTEN MTOR CCND1 PMC9202199__F8 Power of heteronemin in cancers STAT3 BAX BCL2 PMC9202199__F6 Power of heteronemin in cancers FAS PCNA CCND1 FADD PMC4532404__F7 Signaling pathway of focal adhesion CRK BAD VASP FYN HEL-S-28 PTEN ARHA SHE PMC7166610__F2 Illustration of virus activation of IFN‐I synthesis and its inhibition by the MERS‐CoV M, 4a, 4b and PLP proteins TANK IRF3 TRAF3 ISG15 PMC9149322__F8 Illustration of the mechanism of EEZS-induced apoptosis in human bladder cancer T24 cells BAX FAS BCL2 PMC4532404__F8 Signaling pathway of regulation of actin cytoskeleton ABI2 HEL114 GAL PXN F2 APC RHO INS DOCK1 PMC3825194__F1 TGFB signaling through Smad-dependent and Smad-independent pathways TF SMAD2 SMAD6 SMAD4 RHO TRAF6 PMC3825194__F4 TGFB signaling pathway inhibitors under development for potential cancer therapy TF SMAD2 SMAD4 PMC5956756__F7 Proposed mechanistic scheme: miR-29c suppresses breast cancer by the TIMP3/STAT1/FOXO1 pathway STAT1 TIMP3 FOXO1 PMC9579409__F5 Hepatic transcriptome profiling according to growth rate reveals acclimation in metabolic regulatory mechanisms to cyclic heat stress in broiler chickens IDE INA KL APP CS AGA PMC8417882__F5 Harnessing TRAIL-Induced Apoptosis Pathway for Cancer Immunotherapy and Associated Challenges ATF3 ATF4 EIF2A PMC5344005__F1 Molecular functions of long non-coding RNAs (lncRNAs) at different stages of prostate cancer, from prostate adenocarcinoma (A) to ongoing castration resistance (B) to a castration-resistant state (C) TH CKS2 PC ZNF217 SFN EZH2 MDM2 ERG PRUNE2 PMC8417882__F4 Harnessing TRAIL-Induced Apoptosis Pathway for Cancer Immunotherapy and Associated Challenges RHEB BAD PTEN MTOR EIF4E PMC4573218__F3 Some of the proposed signaling pathways activated by NK-R RHO SHE SRC PMC6770188__F5 Our model of the BRAF mutation positive mitogen-activated protein kinase (MAPK) pathway signaling mechanisms SOS1 NF1 GRB2 PMC6088794__F1 Androgen receptor signaling axis and potential androgen-dependent and independent mechanisms of disease progression PTEN MDM2 MTOR PMC8417882__F2 Harnessing TRAIL-Induced Apoptosis Pathway for Cancer Immunotherapy and Associated Challenges MEI1 DIABLO FADD PMC9579409__F3 Hepatic transcriptome profiling according to growth rate reveals acclimation in metabolic regulatory mechanisms to cyclic heat stress in broiler chickens TH BAD KIN PMC3314616__F2 Methamphetamine Causes Differential Alterations in Gene Expression and Patterns of Histone Acetylation/Hypoacetylation in the Rat Nucleus Accumbens NCAN RASD1 GADD45G CRH SOCS3 GH1 PCK1 IFNG PLAT FST IL18 A2M CEBPB GBP2 BIRC3 NOS2 JUN NR1H3 SP1 HEL-S-133P NGFR AGTR1 EPHB1 MIF IL6 TNF NCOA1 FOS GCHFR NR1C1 NFKBIA RGS4 CREBBP PTH HOMER2 TWEAK PMC4081601__F3 Proposed mechanisms of anticancer activity of digoxin EGFR SRC PMC10252649__F1 mTOR Signaling Pathway in Bone Diseases Associated with Hyperglycemia RHEB TSC2 GRB10 TSC1 FOXO1 ULK1 TFEB DEPTOR PMC9311581__F3 Metabolic Adaptation-Mediated Cancer Survival and Progression in Oxidative Stress HEL107 GOT2 FAS HEL-S-133P CD36 HK2 ME1 HEL-S-30 HEL-S-51e RPE SIAH2 OGDH PHGDH HEL-S-162eP PSAT1 PMC7696540__F4 Downstream signaling of EGFR and other receptor tyrosine kinases [,,] FLT3 EGFR MTOR PMC9311581__F2 Metabolic Adaptation-Mediated Cancer Survival and Progression in Oxidative Stress EGF TNPO1 KEAP1 BRCA1 PAQR4 RELA RELB PTEN DPP3 TNF PMC11035635__F2 Core molecular mechanisms of different types of RCD and the potential CAF-derived molecules that regulate RCD ATG101 CXCL12 HMGB1 GSDMD HGF GPX4 ULK1 IL18 AMBRA1 ATG14 MTOR DHODH PMC9503143__SF1 H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish HEL-S-22 KEAP1 NQO1 HEL-S-44 PMC12122316__F4 LncRNAs play a ceRNA regulatory role in RA (by Figdraw) BAX CASP9 FAS PDK4 TLR4 TSPEAR CASP3 ADAMTS9 YY1 COL5A2 SIRT6 PMC10138803__F7 MicroRNA-146b-5p Suppresses Pro-Inflammatory Mediator Synthesis via Targeting TRAF6, IRAK1, and RELA in Lipopolysaccharide-Stimulated Human Dental Pulp Cells STAT3 CD14 IRAK1 IL1A IL6 TRAF6 IRAK4 MYD88 TLR4 RELA JAK1 MTR IL1B PMC9570224__F5 Targeting Phospholipase D Pharmacologically Prevents Phagocytic Function Loss of Retinal Pigment Epithelium Cells Exposed to High Glucose Levels RPE PLD2 PC PMC12122316__F3 Major apoptosis signaling pathways participate in RA (by Figdraw) HTRA2 CASP9 ATR JUN BAD TRADD TNF RAC1 CTNNB1 BCL9 CASP3 ATM NLK TRAF2 CYLD FADD PMC5826678__F2 Three basic mechanisms of aberrant activation of Hedgehog signaling PTCH1 SMO PMC5596586__F6 Diagram showing the mechanisms of CHAC2 BAX CHAC2 ATF4 PMC8229180__F2 AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells RHEB TH ULK1 CDK2 MTOR CDK4 PMC3709411__F1 Illustration of important relationships between metabolome, proteome, and genome in cancerous cells PGAM1 FH HEL-S-133P MYC HEL-S-26 PMC8229180__F1 AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells CDK2 SKP2 CDK4 PMC6237070__F1 Treg suppression CD80 FAS APC LAG3 PMC7464740__F1 General model for the Wnt/Beta-catenin signaling pathway and its regulation by the destruction complex APC GSK3B LRP6 CTNNB1 PMC7758070__F8 Proposed model of GGGGCC repeat expansion pathogenesis TFEB C9orf72 PMC7411263__F7 Genes targeted by DE miRNAs enriched in the downstream of p53 signaling pathway CDK6 CCND2 RRM2B PMC7411263__F6 Hypoxia-related signaling pathways enriched by target genes of DE miRNAs in different tissues, including (A) the HIF-1 signaling pathway in heart, and the insulin signaling pathway in (B) muscle and (C) liver GYS2 AKT3 PCK1 PCK2 G6PC3 TFRC CAMK2A PLCG1 FOXO1 PLCG2 PDPK1 PHKB PI3 FBP1 FLT1 CAMK2G PMC11302868__F2 Four main defense pathways in ferroptosis GPX4 DHODH PMC9157004__F4 High Diversity of Glycosphingolipid Glycans of Colorectal Cancer Cell Lines Reflects the Cellular Differentiation Phenotype MYB FUT1 ETS2 ST3GAL6 FUT2 ST6GAL1 FUT3 EVI1 ST8SIA1 SIX4 CDX1 NR2A1 B3GNT5 B4GALNT1 MSX1 ST3GAL5 B3GALT5 A4GALT HNF1A PMC4254557__F8 Descending Control of Itch Transmission by the Serotonergic System via 5-HT1A-Facilitated GRP-GRPR Signaling GRPR ITCH PMC8613759__F7 CPEB1, a novel risk gene in recent-onset schizophrenia, contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1 NDUFV2 PMC11693940__F8 CXCR2 activated JAK3/STAT3 signaling pathway exacerbating hepatotoxicity associated with tacrolimus STAT3 JAK3 CXCL2 IL8RB PMC9399134__F5 Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis HEL113 KRT14 SOX2 VEGFA MYC TWIST1 AKR1B1 PMC4276806__F2 Proposed pathogenic mechanisms of Alpha-syn-related Lewy body formation in PD ALPI PINK1 LRRK2 PMC7706002__F2 DEGs PPI network complex SKIL HGF PLK2 SYT14 MGST1 CTHRC1 SMOX RUNX2 NET1 CHSY3 POSTN NID2 COL1A1 F3 ADAMTS12 KCNMA1 F2RL1 DCN GBP3 ANAPC10 ADAM19 ROR2 CFH AIM2 VEGFA FOS FGF2 PTPN22 GPR143 SYNC EDN1 FRRS1 TMEM47 SCAP2 CPM CHORDC1 TOX PSPH PRKG1 PMC7204122__F4 Knockdown of IL6 in human endothelial cells affects the gene expression of proteins known to be involved in IL6-mediated signaling STAT3 IL6ST SOCS3 IL6 PMC4553397__F1 Intracellular mechanisms involved in the control of FGF21 production and action on the heart NR1C1 UCP3 FGF21 FGFR1 SIRT1 PMC3118351__F10 Pathways by which BrdU impairs epithelial repair and induces persistent inflammation in the chronic NA injury model ATR ATM IL6 PMC7204122__F8 Merged network showing the interplay between IL6-mediated signaling and interaction, binding, and adhesion of endothelial cells STAT3 PPARG CXCL12 LGALS8 PGR EGFR NFKB2 CCR2 SPARC ATF2 SOCS3 MYC KDR CDH2 VWF CD81 JUN ITGA4 SELL SELE PLAUR PTPN11 KIT ERG FOS CD44 CDK9 PMC6274918__F2 Maternal Beta-Cell Adaptations in Pregnancy and Placental Signalling: Implications for Gestational Diabetes EGF FOXM1 FOXD3 HGF NR2A1 CCND2 PRL EGFR MTOR PMC3920129__F3 TLR ligands/DAMPs, cellular location, and signaling in the vasculature TIRAP IRF3 IRF7 MYD88 PMC3024251__F6 Downregulation of miR-342 is associated with tamoxifen resistant breast tumors ATR FANCL POLE PMC6423797__F4 Regulation of Acetyl-CoA production by Beta-oxidation of fatty acids in mitochondria and peroxisomes, and the interexchange of 2-oxodipate and 2-oxogluterate by SLC25A21 over the membrane of these organelles in cells EHHADH PHYKPL PLOD2 PMC4112529__F1 Pathway for CoQ biosynthesis in eukaryotes TH COQ7 COQ3 COQ2 COQ6 COQ5 PMC6423797__F2 Regulation of immune EP expression by Tumour necrosis factor (TNF) signalling after exposure of IPEC-J2 cells to micro algae extracts in the absence and presence of ETEC FAS CSF1 CR1L TRADD SELE ITCH MLKL PTGS2 IL6 TNF CA12 NOD2 NFKBIA CASP3 MMP3 CASP10 FADD PMC7733318__F8 Proposed working model TGFBR2 ANGPTL4 SMAD4 PSG9 TGFBR1 PMC7940767__F2 Simplified overview of the cAMP/PKA/CREB pathway in the control of GH synthesis and secretion in somatotrophs GHRH GIP GHRHR PMC7699590__F2 Platelet-derived growth factorB (PDGFB)-activated pathways mediating vascular smooth muscle cell (VSMC) migration PAK1 MTOR NOX4 UNK PMC4695187__F8 Antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells TNF PMC3352961__F3 Brain, blood, and iron: Perspectives on the roles of erythrocytes and iron in neurodegeneration VPS13A XK PAK1 RAC1 PMC7017041__F4 PARylation is required for chromatin structural changes following DNA damage CHD3 CHD2 CHD4 H2AX APLF PCGF2 RNF8 ATM EZH2 PARP2 PARP1 PMC2740793__F2 TGFB signaling pathway DBP SMAD2 SMAD4 PMC1852210__F1 Diagram of folate and one-carbon metabolism in mammalian organisms MTHFD2 TCN2 DHFR CTH MTRR TYMS SLC19A1 HEL-S-51e MTHFD1 AMT SHMT1 GGH MTHFS MTR TCN1 FPGS PMC8804151__F1 Lessons from Injury: How Nerve Injury Studies Reveal Basic Biological Mechanisms and Therapeutic Opportunities for Peripheral Nerve Diseases PIGT PIGF ECD ME2 ME1 PMC9519149__F2 Cholesterol biosynthesis pathway, the enzymes involved in the synthesis and the diseases associated with the defective enzymes CYP51A1 EBP SC5D DHCR24 DHCR7 PMC8899174__F7 STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/B‐catenin pathway via binding to Annexin A2 in osteoporosis STARD3NL ALPI ALPL APC ANXA2 RUNX2 CTNNB1 PMC3826841__F1 Regulation of the G2/M transition in the yeast cell cycle CIB2 HP PMC7056924__F1 Metabolic adaptations to acute metabolic stresses in the tumor microenvironment changes central carbon metabolism flow and exposes vulnerabilities CAD CAMKK2 GLS CD36 HIF1A MTOR VHL PMC2768486__F10 Possible mechanism by which BMPs and estrogen regulate GNRH production by GT1-7 cells BMP6 ACTR2 BMP4 BMP2 BMP7 PMC7269868__F2 Diagram showing the ER biogenesis pathway for membrane/secreted proteins, highlighting proteins associated with cystic disease SEC63 ALG6 ALG10 ALG9 ALG3 SEC62 PMC4763967__F1 MiRNAs biogenesis pathway AGO4 RAN AGO1 AGO2 PMC5732723__F4 Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome C6 CPB2 HEL-S-62p F7 CR2 CS C4A PLAT F2R F2 CD9 F10 F3 C9 THBD A2M F8 F9 PROC VWF C7 PLAUR F11 TFPI C2 PMC9878249__F6 SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches TBK1 MAVS IRF3 IRF7 TRAF3 PMC3529762__F11 Illustration of GnRH signaling pathways necessary for FSHB induction ATF2 FSHB PMC7232018__F1 Schematic view of the role of lysosomes in the autophagy pathway FIG4 HEL-S-130P HEL-S-62p TFEB MTOR GLB1 OPTN GNPTAB ATP6AP2 PMC3392049__F3 An example pathway HEL-S-22 RB1 BCL2 PTEN MDM2 LEF1 PMC4061530__F1 Schematic representation of the ribonuclease activity of IRE1 and RNaseL showing cross-talk between the paths catalysed by the enzymes RNASEL XBP1 RAC1 PMC11351413__F2 Biosynthetic pathway of cordycepin PURA ADK PURB ADA PMC6102368__F3 Crosstalk between Notch and tumor necrosis factor A (TNFA) in the tumor environment MOS NUMB FOXA2 HES1 IL1B PMC8004153__F1 TGFB signalling is triggered through BMP or TGFB ligands SMAD1 SMURF1 DKFZp781O1323 SMAD2 SMAD6 TGFBR3 SMAD4 SMURF2 TGFBR1 PMC6102368__F2 Interplay between IL-6 and Notch affects the anticancer immune response TH STAT3 IL10 IL4 IL6 IL6R PMC8004153__F4 The TGFB signalling pathway by miRNAs SMAD2 TGFBR3 SMAD4 TGFBR1 PMC8004153__F3 Hypothetical scheme illustrating TGFB/EMT signalling in SS IFNG SMAD2 TGFBR3 SMAD4 TGFBR1 PMC2293084__F8 PARP-1 in NFAT signaling pathway NFATC4 PARG SRR PMC2796172__F2 Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics HEL107 TMEM97 GLS FABP1 AK3 ACACA CS ACADM DECR1 GLUD1 HADHB NME2 PC ACADVL HEL-S-32 IDI1 MDH2 OPLAH PKLR ECHS1 ACOX1 GOT2 FH HEL-S-133P FASN PCK2 AADAC PGAM1 TG DLAT PDHA1 HEL-S-68p HEL-S-49 ENO1 HEL-S-87p AK4 PMC3962152__F4 KEGG Pathway database map showing Notch signaling including proteolytic cleavage and translocation of Notch followed by transcriptional activation of Notch target genes NUMB HES1 HES5 PMC9253751__F9 Pre‐ and post‐conditioning with poly I:C exerts neuroprotective effect against cerebral ischemia injury in animal models: A systematic review and meta‐analysis TBK1 TLR9 IRF3 IRF7 TRAF6 TNF IRAK4 MYD88 PMC9161009__F8 The unique telomere protection mechanism in ES cells ZSCAN4 ATR ATM MDC1 BRD2 PMC3286890__F1 Wnt/Beta-catenin signalling and Beta-catenin role in adhesion in glioma cells EGF EGFR APC CTNNB1 PMC6433075__F10 Proposed model of glycogen phosphorylase regulation by epidermal growth factor receptor in human Kit 225 T cells RAF1 EGFR GRB2 PMC9878249__F4 SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches TBK1 MAVS IRF3 TRAF3 PMC9878249__F3 SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches TBK1 MAVS IRF3 IRF7 TRAF3 PMC8843880__F6 Tumor microenvironment pathways: Cross regulation in breast cancer metastasis CD44 SOX9 MMP9 MYC CCND1 NOTCH1 CTNNB1 PMC9399134__F1 Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis CD44 HEL-S-62p VTN SMAD4 ARHA PMC7957022__F3 CAFs drive resistance-related paracrine pathways in the TME STAT3 HGF SHH ATP7B STC1 IRAK4 IL1B ATP7A PMC9399134__F2 Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis CDC42 HEL-S-92n HMGB1 ATR ATM MYC CD47 PMC7957022__F5 Main signaling pathways responsible for therapeutic resistance mediated by the tumor environment STAT3 HEL-S-133P MTOR TRAF6 KRAS PMC5020319__F3 De novo sequencing, assembly and analysis of eight different transcriptomes from the Malayan pangolin PI3 IL2 PTEN PMC4813194__F2 The intrinsic apoptotic pathway is triggered by various stimuli inducing mitochondrial membrane permeabilization BAX TRADD TNF FADD PMC9142561__F9 Early molecular events leading to COFILIN phosphorylation during mouse sperm capacitation are essential for acrosomal exocytosis LIMK1 SSH1 ARHA PMC3201973__F9 Toll-like Receptor 3 Regulates Neural Stem Cell Proliferation by Modulating the Sonic Hedgehog Pathway FAS TLR3 PTCH1 SHH SMO PMC3531712__F1 p62-interacting partners and functions KEAP1 MTOR TRAF6 PMC2645343__F2A Drug development against metastasis-related genes and their pathways: A rationale for cancer therapy HGF PLG CTNNB1 PMC9478949__F10 Alternative splicing of Arabidopsis G6PD5 recruits NADPH-producing OPPP reactions to the endoplasmic reticulum ATR FAS GPT2 PMC1919358__F5 WNT signalling KEGG pathway consisting of three subpathways with the genes on the microarray encircled (A) and expression profiles of genes during porcine myogenesis (B) TCF3 CSNK2B CTNNB1 PMC2690004__F3 Metabolic reconstruction of H APC PTS FES PMC6712555__F2 Vascular inflammation during tumor cell extravasation and metastasis APBA3 CCR2 CR2 VCAM1 MMP9 VEGFA CCL2 IL1B PMC2775948__F2 Integrated Proteomic Analysis of Human Cancer Cells and Plasma from Tumor Bearing Mice for Ovarian Cancer Biomarker Discovery TGFB1 FSTL1 C3AR1 IFI30 LYZ ENPP1 MERTK PLAA TYRO3 PROS1 SCGB3A1 MARCO FBLN2 UNK THBS1 GLRX2 CST7 NEU3 FASN SLC12A7 AIM2 PTGES3 SIRPA APOB LCN2 GCNT1 PMC9459699__F7 Different Effects of Low Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Function and Insulin Secretion in Adolescent Male Rats LCN2 TNF GPX1 SELENOP IRS1 PMC6888337__F11 Canonical pathway explaining the NASH progression from steatosis to hepatocellular carcinoma PNPLA3 VLDLR SCD FASN PLIN1 FADS2 APP ADFP SMPD2 FADS1 YWHAZ PMC5831833__F1 Schematic overview of the autophagy pathway and target points of its modulators RHEB ATG3 ATG12 ATG14 ATG5 ULK2 PMC8320331__F2 Epigenetic Mechanisms Involved in HCV-Induced Hepatocellular Carcinoma (HCC) FAS CACNA1G RXRA APC RASGRF2 LRP5 LRP6 DUSP4 CCND1 CTNNB1 PMC6073924__F5 Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges HGF FOS PMC4046519__F4 Network analysis performed on converging genes differentially regulated in response to different stresses in mouse and between different selected Flinders lines TIMP3 PTN VAMP2 TTLL7 TUBB2A INSRR TTC3 TUBB8 ARC EML1 MYLK3 PMC11978951__F5 Molecular interactions and downstream effects of the HIF-1 signalling pathway MOK TFRC HEL-S-133P EPO HEL-S-87p PMC12066067__F6 Samples for metagenomic analysis based on part of the basal metabolic pathways from the KEGG database NAPA ACLY SDHA PMC3158739__F1 Ingenuity pathway analysis (IPA) of CDF driven pathway changes in BxPC-3 cells ARAF CAV2 SPARC TRIM71 HTATIP2 ABCG2 DFFB COL3A1 MYC CTNNB1 PMC7269823__F3 Changes in extracellular matrix (ECM), focal adhesions, and integrin signaling in ADPKD LTBP1 RAF1 SMAD2 BRAF HEL-S-28 ARHA MTOR PMC8505796__F1 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer RARA HEL-S-53e RARB PMC5811049__F7 dWnt4 switches Beta-catenin dependence during oogenesis CDC42 ARHA RAC1 CTNNB1 PMC11534180__F6 GABAergic synapse pathway modified from the KEGG database [29] GLS GLA PMC11978951__F4 Astragaloside A against lung adenocarcinoma based on network pharmacology combined with molecular dynamics simulation technique STAT3 PIK3CA EGFR TYMS ACACA MTOR ITGAV BCL2L1 TLR4 MUC1 CHUK MMP2 GCK MDM2 SRC HEL-S-26 CDK4 PTPN11 VEGFA FGF2 ITGB1 NFKB1 RXRA PDGFRA NFE2L2 CREBBP CDK2 CFTR EP300 CYP3A4 BCL6 PMC7305134__F5 TIE and the canonical TGFB signaling pathway regulated by ncRNAs TF IFNG SMURF1 SMAD2 SMAD4 FOXP3 SMURF2 TGFBR1 PMC11534180__F5 Synaptic vesicle cycle pathway modified from the KEGG database [29] SNAP25 PMC7305134__F4 TIE and immune checkpoint molecules regulated by ncRNAs ZAP70 EIF4B APC BTLA PTEN MTOR PMC7305134__F3 TIE-associated stem cell signaling pathways by ncRNAs SUFU APC PTCH1 SMO CTNNB1 PMC1751493__F2 In normal prostate epithelial cells (a), TGFB binds to the TBRI and TBRII receptors, activating the SMAD signalling pathway and inducing the transcription of IGFBP-3 and other regulatory genes IGF1 PI3 PMC5412347__F7 The VEGF/VEGFR/HIF-1A signaling pathway and the effects of melatonin treatment leading to the activation or repression of downstream molecules in OC cell TGFB1 SMAD2 ME1 PMC2972203__F8 Reverse-Phase Phosphoproteome Analysis of Signaling Pathways Induced by Rift Valley Fever Virus in Human Small Airway Epithelial Cells STAT3 STAT1 BAD IRS1 PMC5938400__F1 Mechanism of action of pharmacologic therapies MAFK EGFR PMC8505796__F3 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer STAT3 ALDH1A3 HGF SP1 NF1 DDIT3 GRB2 MTOR PMC8505796__F2 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer HEL-S-53e SMAD4 CTNNB1 PMC8505796__F5 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer BMI1 CCNE1 HEL-S-53e NEK2 CDK2 SIRT2 PMC4664161__F4 TLR4 and TLR3 sensitization TLR3 TLR4 MAL IRF3 IRF7 TRAF6 TNF UNK MYD88 PMC5437015__F8 Canonical Pathway of ‘Molecular Mechanisms of Cancer’ (IPA, p-value 0.0199) MAX BAD CYCS HIF1A RHO MYC FANCD2 FYN HIPK2 NF1 ATM MDM2 SRC CCND1 BAX CD2 RBL1 CBL BRCA1 FOXO1 SUFU RS1 BCL2 LEF1 FADD PMC3419258__F6 Proposed model of FGF23 signaling in proximal tubular cells SGK1 FGFR1 PTH FGF23 PMC5492501__F4 Myristoylation in regulating Fas/Fas ligand pathway during cytotoxic T cells activation: binding of a death ligand to Fas receptor leads to the formation of death-inducing signaling complex (DISC) BAX BAD FAS NMT1 NMT2 FADD PMC5492501__F3 N-myristoyltransferase functions during T cell activation ZAP70 PLCG1 LAT APC MARCKS MCU FOS LCK PMC11497461__F1 Graphical representation of imatinib metabolism and transport CYP1A2 BCR CYP2C19 CYP2C9 KIT CYP2C8 SLC22A1 ABCG2 CYP1A1 CYP3A4 ABCB1 PMC8697849__F6 Combined Oral Contraceptives and Venous Thromboembolism: Review and Perspective to Mitigate the Risk SRC PMC3424007__F1 Biological association network (BAN) of differentially expressed genes in common between CA and ICC LONP1 EPO TNF INS MPL NCOR2 TSLP POLE4 RALA EPOR NPTN THPO GHR PMC5372717__F4 Localization of Moco biosynthesis, FeS cluster biosynthesis and tRNA thiolation in humans MOCS3 URM1 FES CTU1 PMC6514876__F10 Model outlining biomarkers and pathways between CTCs and PMN-MDSCs interactions (CTC/PMN-MDSC cluster) isolated from blood of metastatic cancer patients CRIPTO NODAL NOTCH1 PMC7226524__F2 Methionine metabolism MAT1A PMC7518341__F1 Angiotensin-converting enzyme 2 (ACE2) causes the production of angiotensin (1-7) Ang-(1-7) from angiotensin-2 (AngII) IL19 BAX ATR BDNF ACE2 PMC5689704__F5 Screening circular RNA expression patterns following focal cerebral ischemia in mice NKD1 RASSF6 ID2 PATJ APC GSK3B SOX2 AREG MYC ID1 CTNNB1 LATS1 BIRC5 LATS2 AFP AMOT BIRC2 PMC6071262__F6 Schematic drawing of the 1-carbon methylation cycle PMC5586504__F1 Regulation of Wnt Signaling by Protocadherins CDC42 APC GSK3B AXIN1 LRP5 LRP6 RYK NLK RAC1 DAAM1 CTNNB1 PMC8703161__F4 Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration FGF8A CXCL16 PMC11604295__F2 Functions of TDEVs in tumor progression HEL107 PFKP HK2 EGFR MSC HEL-S-87p KRAS ADA PMC9367256__F2 Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews EGF PTEN MTOR CCND1 PMC4662481__F7 Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer PTEN JAK1 MYC PMC2679155__F1 Integrin-RTK signaling HEL-S-28 PTEN NCK2 PMC5064990__F3 KEGG pathway for insulin signaling RHEB TSC2 BAD INSR GRB2 MTOR INS PMC8062415__F7 Hub genes associated with Interleukin-3-mediated signaling pathway THBS1 PAPPA2 IGF1 IGFALS VTN FHL2 LYN IGF2 HES1 PMC8454558__F5 Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors AURKA EGF HGF CRKL PTEN MTOR PLK1 CDKN2A FOXM1 AURKB GRB2 SRC CDK4 PMC5363569__F8 Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone POSTN TRANK1 TGFB1 VEGFA PMC6478727__F2 Differentially expressed coat color genes in Changthangi Pashmina goat and their involvement in melanogenesis signaling pathway (Adapted from ref.) DCT TYRP1 CTNNB1 PMC3640511__F3 PRR activated signaling and antiviral responses during virus infection MAVS IFIT1 TLR9 AIM2 IRF1 IFI16 IRF7 IRF8 CXCL10 CTNNB1 NLRP3 TLR3 TLR4 IRF2 DDX41 TLR8 TLR7 IL1B PMC8073242__F6 Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells CTRL PGAM1 HEL-S-133P HEL-S-68p HEL-S-49 HEL-S-162eP ENO1 HEL-S-87p HEL-S-30 GLRX IL1B PMC8073242__F4 Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells CTRL PGAM1 HEL-S-133P HEL-S-68p HEL-S-49 HEL-S-162eP ENO1 HEL-S-87p HEL-S-30 GLRX IL1B PMC3702291__F7 Schematic model of signaling pathways in salinomycin-induced cell growth inhibition and apoptosis STAT3 BAD APC CDK2 SKP2 CCND1 PMC8241721__F2 Heme oxygenase 1: a novel oncogene in multiple gynecological cancers BAX KEAP1 PMC5868594__F2 MicroRNAs in the nuclear factor kappa B signaling pathways TRADD RELB TRAF5 TRAF3 TRAF2 MYD88 PMC5868594__F1 Nuclear factor kappa B and its activation mechanisms RHD RELA RELB PMC2796989__F1 Interleukin (IL)-13/transforming growth factor (TGF)B signalling pathways IL13RA1 IL13RA2 PMC9317121__F12 BMP Signaling Pathway in Dentin Development and Diseases TF SMAD1 DKFZp781O1323 SMAD4 PITX2 PMC9317121__F11 BMP Signaling Pathway in Dentin Development and Diseases Pax9 DSPP BMP3 DMP1 MSX1 BMP2 BMP5 RUNX2 MSX2 PMC3580410__F4 Functional interaction sub-network constructed by using module 2 genes ZW10 CENPO AURKC SPC25 NSUN2 CENPH BUB1B NCAPG CENPN ANKZF1 KIF20A CENPE PMC9317121__F10 BMP Signaling Pathway in Dentin Development and Diseases Pax9 SMAD1 DKFZp781O1323 DMP1 BMP3 SMAD6 SMAD4 RUNX2 DSPP MSX1 BMP4 BMP2 BMP5 MSX2 PMC8161962__F5 Persistent Newcastle disease virus infection in bladder cancer cells is associated with putative pro-survival and anti-viral transcriptomic changes NKD1 CDH2 PRKD1 GLS CEMIP SULF2 HTATIP2 AXIN2 FGF8A SPRY2 KLK6 MIA EFNB1 INHBB CKMT2 LEF1 GJA1 SP5 SOX4 ARG2 CLDN1 PMC3140915__F1 Simplified schematic of the Wnt/Beta-catenin signaling pathway APC GSK3B CTNNB1 PMC7716749__F1 Schematic diagram showing chondrocyte stages in the growth plate during development and selected signals that regulate these processes, including PTHrP, IHH, WNTs, FGFs, BMP and TGFB, IGF1 and IGF2 IGF1 HEL-S-162eP BMP2 IHH IGF2 FGF2 PMC9272757__F2 Bacillus subtilis Produces Amino Acids to Stimulate Protein Synthesis in Ruminal Tissue Explants via the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta–Serine/Threonine Kinase–Mammalian Target of Rapamycin Complex 1 Pathway MLST8 MTOR DEPTOR EIF4E PMC6798084__F1 Nicotinamide adenine dinucleotide (NAD+) metabolism in plant cells PXN HEL-S-162eP NADK PMC4585666__F1 Combination of transcriptomic and metabolomic analyses reveals a JAZ repressor in the jasmonate signaling pathway of Salvia miltiorrhiza MYB MPG CAD AMT MYC PMC5924972__F1 Saikosaponins and implications for age-related diseases SIRT3 NLRP3 SSB PMC8396502__F3 Liquid Biopsy for Cancer Cachexia: Focus on Muscle-Derived microRNAs PGC ALK IGF1 BNIP3 IGF1R YY1 MTOR PMC5489427__F2 Purinergic signaling in microglia in the pathogenesis of neuropathic pain CCR2 LYN MDM2 IRF8 CCL2 EIF4E PMC3688534__F10 Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors CRX CCPG1 SP1 C5orf34 DNAJC21 WNT2B MMP11 MNDA CEBPA NDUFA3 BDNF PCTP PPP1R16B HTT OPN1LW PMC8421236__F2 Daily Rice Bran Consumption for 6 Months Influences Serum Glucagon-Like Peptide 2 and Metabolite Profiles without Differences in Trace Elements and Heavy Metals in Weaning Nicaraguan Infants at 12 Months of Age CAP2 HEL-S-5 PC PMC6796064__F1 Conceptualized overview of the association between inflammation and angiogenesis IFNG HGF IGF1 CRABP1 RNF213 CTNNB1 PMC7836022__F1 Metabolic pathways and signaling in cancer MAL MYC CIT PMC6335683__F1 Crosstalk between hepatocytes, hepatic nonparenchymal cells, and ncRNA during the pathology of NAFLD STAT3 TG LOX CD36 WNT1 SOCS3 IL6 PMC3598852__F3 Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis CRK JUN BAD VASP HEL-S-28 PTEN ARHA SHE PMC5302955__F6 IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin ATR IGF1R IRS1 PMC7716145__F3 LPS-producing bacteria interact with TLRs through the NFKB signaling pathway TRAF4 IL18 IL6 TNF TRAF2 MYD88 PMC3598852__F5 Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis MAX ECSIT EGF FAS RAF1 CD14 TNF FLNA NFIB NLK GCK GRB2 BDNF PMC3598852__F4 Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis LEP SIAH1 ROCK2 STOM APC CER1 SMAD4 SKP1 ARHA NLK PROC DAAM1 PMC5648141__F1 Inferring gene and protein interactions using PubMed citations and consensus Bayesian networks PIM1 MTOR PMC6976991__F4 Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications ACHE CYP2E1 INSR ADIPOR1 F3 PMC4580963__F1 Overview of Cr metabolism and the methionine cycle GAA HEL-S-182mP HEL-S-20 PMC4491686__F3 Intracellular calcium and cell survival: Intracellular calcium activates the intermediate proteins in the signalling pathways in neuroblastoma CASR EGF NGF BAD ALK EGFR BDNF PMC5039077__F23 Overview of the GO-induced cytokine response and autophagy mediated by the TLR4/TLR9 signaling pathway TLR4 TLR9 IRF3 TRAF6 MYD88 PMC4124053__F2 Apoptosis and the FLIP and NF-kappa B proteins as pharmacodynamic criteria for biosimilar TNF-alpha antagonists BAX TNF DIABLO PMC5943909__F1 Summary of the proposed mechanisms involved in the regulation of gene expression by PNX in mHypoA-GnRH/GFP and mHypoA-Kiss/GFP-3 cell models KISS1 GNRHR GPR173 PMC4669553__F3 PLD–PA involvement in lipid metabolism and signalling and impact on SA biosynthesis and signalling in plant defence LPA LOX GLS HPR HEL-S-162eP HEL-S-5 PC MYC PMC4895251__F3 Proposed model depicts that canonical Notch signaling augments the expression of Klf4/5, resulting in conjunctival goblet cell differentiation by down-regulating proliferation and up-regulating transcription of Muc 5/ac in conjunctival epithelium KLF4 MUC5AC KLF5 PMC6900666__F7 mTOR signalling pathway identified by KEGG analysis of the target genes of the DElncRNA EIF4B EBP TTI1 PTEN FLCN MTOR RHO DEPTOR EIF4E RHEB RICTOR SESN2 RNF152 GAB2 PMC6900666__F6 CAM signalling pathway identified by KEGG analysis of the target genes of the DElncRNA PTPRM CD226 CD40 NRCAM CD36 CD22 PTPRC CD99 JAM2 CDA ITGA6 CNTN2 CDH4 CD6 CDH2 CD2 ESAM MPZ SELL SELE APC CTLA4 CLDN2 CD34 SPN ICOS TIGIT ITGAM tal-1 ITGB1 PTPRE SELP PMC7401253__F5 Scheme highlighting the pathophysiology of neurodegenerative disorders and post-ischemic consequences along with indicating the underlying mechanism of neuroprotective action of algal compounds ACHE APOE BDNF PMC3907011__F5 Schematic diagram of the Bcl-w-induced signaling pathway by the activation of Sp1 SP1 SOX2 PMC9230675__F6 Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells RAD51 BRCA1 BRCA2 ATM PARP1 PMC6406872__F3 Structural hotspots and signaling pathways that are essential to the hepatic phenotype of highly differentiated HepaRG cells PTPRF PSEN1 LAMB1 EZR CACYBP ANTXR2 RDX CDH2 FBN1 SP1 SPTBN1 HEL114 RBX1 IL17RA PRKCI PARD3 ADAM9 FCGRT CDC42 F11R FAS TIMP1 HGF HSPG2 VASP EGFR RHO INS CTNNB1 LMO7 TFRC LIN7C TPM3 LSR CTBP1 HEL-S-108 EPHB4 CXADR GPC1 CGN TJAP1 ASGR1 PTPN6 TLR3 SKP1 SCRIB NLK M6PR CLDN1 PMC3494149__F6 VANTED integrated pathway map of quantitative regulation of metabolites and enzymes of primary metabolism under nitrogen limitation in Chlamydomonas reinhardtii PALM MAL GIP MDH2 UROS CIT PMC5515036__F1 Biosynthetic pathway of cysteinyl leukotrienes (cysLTs) and cross regulation of their receptors LTB GPR17 LTA PMC5811677__F3 Key signaling pathways affected by CD5 expression STAT3 SYK STAT1 CD5 VAV1 LYN MTOR PMC12240740__F3 Network pharmacology results PPARG STAT3 RAF1 MCL1 HIF1A MYC CCL2 RB1 IFNG STAT1 BCL2L1 PRKCA THBD MMP2 MMP3 MDM2 NOS2 IRF1 IL1A VEGFA CXCL10 FOS CXCL11 HMGCR CDKN1A RXRA TP63 ADRB2 APOB BCL2 HEL-75 EGF PGR PCNA EGFR ACACA NCF1 MPO PLAT SLC6A3 INSR NR3A2 F3 HSF1 CHEK2 AHR CHUK IL2 ABCG2 RXRB TOP2A IL1B CRP CYP1A2 BAX JUN E2F2 SELE FASN IL4 CXCL2 CD40LG MMP9 PTGS2 IL6 CYP1A1 IGF2 NR3C1 SPP1 CD44 NR1C1 HEL-S-130P IKBKB RELA CASP3 NFKBIA ERBB2 PTGES CYP3A4 PMC2854298__F8 AATF mediates anti-apoptotic effect of the unfolded protein response through transcriptional regulation of AKT1 STAT3 EIF2A WFS1 AATF PMC6108862__F4 Functional analysis of transcription factors and genes in dysregulated miR-FFLs STAT3 CTF1 APP ARHA MYC GATA4 RAC1 FOS PMC7554191__F9 Mechanism of EMAP II/ S1P signaling and modulation of S1P homeostasis S1PR1 S1PR3 EGR1 S1PR2 SPHK1 S1PR5 S1PR4 PMC4002915__F2 Signal pathways of IL-17 IL17RC IL17RA GSK3B IL17A TRAF3 JAK1 TRAF6 PMC6909960__F1 Multiple factors regulate COX-2 expression NGF EGFR IRAK1 AHR CDC37 PTGS2 HSD17B7 TRAF2 MYD88 PMC5910288__F3 Interactions between cellular metabolism, the circadian molecular clock, and ion channels CSA2 SIRT3 INA PRX NAMPT PMC4136892__F7 Signaling pathway regulation in human schwannomas AXL NF2 PMC3539739__F1 Oncogenic Transcription Factors: Cornerstones of Inflammation-Linked Pancreatic Carcinogenesis STAT3 CCND3 EGF HGF EGFR VMP1 TNF CDK6 SUFU SHH SMO VCAM1 CXCR4 CCND1 CDK4 PMC4574709__F2 Meta-Analysis of Microarray Data of Rainbow Trout Fry Gonad Differentiation Modulated by Ethynylestradiol DBF4 RAD21 CDK7 PCNA E2F4 CDC45 SMAD4 CDK2 MDM2 PLK1 SKP2 PMC8276021__F4 T Cell Protein Tyrosine Phosphatase in Glucose Metabolism STAT1 POMC NPY AgRP JAK1 GHR PMC2940738__F7 ETS-4 Is a Transcriptional Regulator of Life Span in Caenorhabditis elegans IGF1 PMC5145803__F1 Redox states of the mitochondrial NAD and NADP pools are determined by a range of interconnected pathways NADK PRX HEL-S-32 AGA HEL-S-26 NNT NDP PMC8492275__F1 Therapeutic Effects of Polyphenols on the Treatment of Colorectal Cancer by Regulating Wnt Beta-Catenin Signaling Pathway APC CTNNB1 PMC5726210__F3 The vitamin K cycle MGP GLA PMC5161652__F7 Signaling events leading to MYC and YAP upregulation MTOR MYC KRAS PMC6289210__F1 MALAT1 in cancer pathways.Notes: MALAT1 promotes generation of the six phenotypes of cancer CDH2 BAX SYK FOXM1 NLRP3 ELAVL1 DKK1 IL6 CTNNB1 PMC6102368__F5 VEGF and Notch interaction in physiological and tumor angiogenesis FGF7A FGFR1 NRP1 VCAM1 NOTCH2 NOTCH3 NOTCH1 PMC6169142__F3 The protein C pathway C2 F2 PC CS C4B_2 PMC8347175__F2 Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx FADS3 DEGS1 DEGS2 PMC6370526__F1 Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology ATF4 TRAF2 PMC10237023__F2 Intratumour microbiome of pancreatic cancer SYK CD81 NLRP3 TLR4 CXCL1 IL33 CXCL2 IL8RB CARD9 PMC11806117__F7 Amino acid metabolism during liver repair and regeneration GLS FOXO1 EGFR FASN CCND1 PMC11806117__F6 Lipid metabolism during liver repair and regeneration MIER1 EGF HGF HEL-S-67p EGFR FASN PTEN ABCA1 CTNNB1 MYD88 FOXM1 NR1C1 EIF2S1 LOX RNF43 HMGCR NCOR1 COX2 CYP7A1 FGFR4 TRIB1 ZNRF3 CPT1A CCND1 PMC11806117__F4 Canonical signaling pathways involved in liver repair and regeneration STAT3 AURKA NR1C1 CXXC5 RNF43 APC ZNRF3 SMO SOCS3 NOX4 SIRT1 CTNNB1 PMC5998149__F5 Pathway analysis of selected metabolites PMC5390009__F1 Downstream signaling pathway of cytokines sharing the common G chain receptor: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 STAT3 STAT1 JAK3 IL15RA PMC5056018__F1 Estrogen Signaling Pathway TF TGFA SRC MYC PMC9709426__F2 Targeting ferroptosis, the achilles’ heel of breast cancer: A review STAT3 ACSL3 GPX4 SUFU DKK1 FGFR4 FACL4 HLF TCF4 SLC7A11 DDR2 PMC9709426__F1 Targeting ferroptosis, the achilles’ heel of breast cancer: A review TF POR SLC3A2 HMGCR GPX4 LPCAT3 SLC7A11 PMC2064799__F9 New calpain-dependent switch that controls cell spreading and retraction CDC42 ARHA RHO SRC PMC7697663__F3 Early antigen-driven transcriptional pathway in effector CDT8 T cells and in exhausted CD8 T cells BATF TOX IRF4 TNF RUNX3 PMC11594238__F4 Hormone synthesis and signal transduction pathways ERF EBF2 LOX ALK CPD NCL PMC7697663__F1 c-Jun/activator protein-1 (AP-1) regulation and biological activity BATF ATF2 IRF4 PMC6507908__F9 Elevated androgens alter intrafollicular regulatory mechanisms that impact the expression of VCAM1 and the expansion of VCAM1+ cells in the stroma CYP17A1 NR2F2 VCAM1 FSHR PMC5327483__F4 New targets to alleviate skeletal muscle inflammation: role of microRNAs regulated by adiponectin MAP3K7IP1 CASP8 TIRAP TLR4 IRAK1 TRAF6 IRAK4 IL1B FADD MYD88 PMC10367551__F8 Mechanism by which miR-552-3p alleviates liver fibrosis and inflammation TGFBR2 COL1A1 ACAT2 SMAD2 SMAD4 COL3A1 CCL2 TGFBR1 PMC11577739__F9 Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPARG /FDX1 signaling ACTA2 DLAT BMP2 FDX1 RUNX2 ATP7A PMC3079441__F3 Pharmacological activities of cardiotonic steroids such as ouabain EGFR NACA2 SRC PMC8677397__F5 Sishen Pill Maintained Colonic Mucosal Barrier Integrity to Treat Ulcerative Colitis via Rho/ROCK Signaling Pathway WAS PTEN RHO NOTCH1 IL1B PMC4931096__F1 Biosynthetic pathways and the transformation of H2S in the mammalian body VIT DAO PMC12228400__F11 Schematic diagram illustrating the antagonistic mechanism employed by ASFV MGF505-4R on IFN-I responses TBK1 CGAS STAT2 IRF3 JAK1 TYK2 PMC4933697__F2 Signaling pathways involved in platelet-mediated NET formation TLR4 CSK SRC MPO PMC8850700__F1 LncRNA DUXAP10 Could Function as a Promising Oncogene in Human Cancer EZH2 MTOR CTNNB1 PMC5818890__F4 Common highly linked molecules and their most significantly related signaling pathways and functions in the “matrine-CRC” merged network HMGB1 RAN MSH2 PMS2 PTEN RHO TNF MYC IFNG BCR TLR4 CREBBP HEL-S-11 SRC GPT CP PMC8850700__F2 LncRNA DUXAP10 Could Function as a Promising Oncogene in Human Cancer GPR39 MTOR CTNNB1 PMC8773517__F3 Oxysterols in the Immune Response to Bacterial and Viral Infections OSBP CH25H ATF4 EIF2A PMC8773517__F2 Oxysterols in the Immune Response to Bacterial and Viral Infections CH25H IRF3 IRF7 GPR183 CYP27A1 PMC9208265__F3 Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy MAPK1 HMGB1 LPO GPX4 TLR4 MTOR CCL2 MAPK3 PMC9208265__F2 Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy SLC3A2 STAT1 GSDMD NLRP3 LPO CD36 GPX4 GZMA GSDMB SLC7A11 DFNA5 PMC7382747__F3 Relevant signaling pathway in itaconate-induced anti-inflammatory and antioxidative effects ATF3 CAD KEAP1 IL16 HEL-S-162eP F3 HEL-S-87p PMC4435780__F1 Adipocyte receptors that have been proposed to promote the browning of white fat or maintenance of a brown adipocyte (BA) phenotype NR1C1 PRDM16 PLIN1 UCP1 BMP7 ATF2 TRPM8 SIRT1 PMC3181077__F1 NFKB activation pathways and the impact of S-glutathionylation RELA RELB IL1B PMC9304715__F5 Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NFKB Pathway BAX TLR4 PEBP4 MPO PMC7204633__F2 Hypoxia driven interaction network that links CHI3L1 and TNFRSF12A to thyroid cancer ALB CHI3L1 TNFRSF12A BCL2 MMP9 VEGFA INS PMC4614824__F1 Cystathionine Gamma-lyase (CSE), the biosynthetic enzyme for cysteine is depleted in Huntington's disease (HD) at the transcriptional level SP1 NHS TAF4 PMC3413998__F6 Canonical Wnt signaling pathway APC GSK3B LRP5 FGF20 LRP6 MYC CTNNB1 PMC9100302__F1 An overview of current drugs and prophylactic vaccines for coronavirus disease 2019 (COVID-19) ACE2 PMC7013599__F4 Gene expressions in the fatty acid biosynthesis pathway (Ko00061) in response to Bgt infection FAS FBL FASN FES PMC8524389__F4 Proteomic signatures for perioperative oxygen delivery in skin after major elective surgery: mechanistic sub-study of a randomised controlled trial TH APP PMC9395173__F1 Using human data on cardiovascular risk associated with T1DM to guide mechanistic studies in mouse models APOC3 S100A8 S100A9 PMC8529875__F5 Mini Review: Biomaterials in Repair and Regeneration of Nerve in a Volumetric Muscle Loss TFAM HEL-S-62p C2 UQCRH YY1 NRF1 PMC8836112__F1 Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport CBL INSR PMC6362621__F1 VEGFA-VEGFR2 signaling pathways and their pharmacological inhibition occur across the glomerular filtration barrier BRAF MTOR VEGFA PMC1828071__F1A Intracellular Signaling in Insulin-mediated Regulation of Drug Metabolizing Enzyme Gene and Protein Expression EIF4B BAD MTOR PDK2 EIF4E RHEB CRK TSC2 PDE3B RICTOR TSC1 GRB10 GSK3A IGF1 FOXO1 GRB2 PMC4855676__F2 NFAT signaling pathway JUN IRF2BP2 FOS PMC8001776__F2 Routes for the in vivo production of glyceraldehyde (GA)/methylglyoxal (MGO) HEL-S-162eP GLO1 PMC3877547__F9 Schematic model of cancer-derived IgG to enhance cell growth and proliferation through inducing the production of a low level of ROS RAN PMC6400807__F7 The sketch of the mechanism of lncRNA SNHG16 on JAK2/STAT3 signaling pathway STAT3 PMC5932832__F3 Proteins of acute-phase signalling at stage II compared with stage I in non-responders to autologous chondrocyte implantation (ACI) CRP OSM AMBP PLG HRG HAMP HEL-S-78p CORT AHSG HEL-S-92n MBL2 APOH F2 FGA LBP PMC9400419__F1 Targeting the Hippo pathway in heart repair LATS1 LATS2 PMC3732055__F1 PAM and Copper – a Gene/Nutrient Interaction Critical to Nervous System Function ATOX1 ATP7B ATP7A PMC4855676__F5 Regulation of the apoptosis signaling pathway by NFAT proteins BAX CAD TRIM17 BDNF DIABLO PMC3256998__F5 Alpha-Tocopherol Alters Transcription Activities that Modulates Tumor Necrosis Factor Alpha (TNFA) Induced Inflammatory Response in Bovine Cells CD74 COX2 MIF PMC3928478__F2 Inositol phosphates and Akt/PKB inhibition, a potential Akt/PKB feedback mechanism.Note: Adapted from Cell, 143(6), Manning BD, Insulin signaling: inositol phosphates get into the Akt, 861–863 IP6K1 IRS1 PMC5707523__F1 Viral modulation of death-receptor mediated apoptosis BAX FAS TRADD TNF TRAF2 FADD PMC4464690__F3 Crosstalk between Wnt, PTH and BMP signalling in cartilage and bone cell lineages DKK1 LRP5 MSC LRP6 PTH PMC3256998__F6 Alpha-Tocopherol Alters Transcription Activities that Modulates Tumor Necrosis Factor Alpha (TNFA) Induced Inflammatory Response in Bovine Cells PAK1 LBP PMC9103886__F1 Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study STAT3 HGF MMP2 BCL2 MMP9 SRC CCND1 PMC5915505__F2 HIF degradation pathway in normoxia and its stabilisation in hypoxia and pseudohypoxia HYI FH VHL PMC6770306__F2 DNA damage response network in SCLC cells RAD21 ATR ATRIP RAD51 BRCA1 PAXX ATM PALB2 PMC4075038__F3 Signal Transduction in Vasculogenesis and Developmental Angiogenesis CDC42 SHB IQGAP1 HDAC7 SRC PMC4233246__F7 A model of how a p66B/Sufu complex inhibits Gli transcriptional activity and a Mycbp/Gli complex enhances Gli transcriptional activity in the nucleus SUFU MYCBP PMC5861430__F8 Working model of the molecular mechanism of APE2-mediated ATR–Chk1 DDR pathway from a defined SSB structure TOPBP1 ATR ATRIP PCNA SSB PMC4511103__F4 Programmed Cell Death in Animal Development and Disease WNT3 CP PMC8484370__F3 Distinct TLR signaling in the salamander response to tissue damage TBK1 TAB3 TLR9 IRAK1 TLR5 IRF3 IRF7 ATF2 TRAF3 TRAF6 IRAK4 MYD88 TLR1 TLR3 TLR7 PMC4940079__F6 Differentially expressed gene distribution in the rno03320 pathway LPL UBC AQP7 UCP1 HEL-S-28 PLTP PMC6698931__F1 The Function and Therapeutic Potential of Epstein-Barr Virus-Encoded MicroRNAs in Cancer BAX CASP9 BAD FAS CASP8 TRADD CASP3 TNF CASP10 TRAF2 MST065 FADD PMC4940079__F7 Differentially expressed gene distribution in rno03320 pathway LPL UBC AQP7 APC UCP1 HEL-S-28 PLTP PMC3159971__F2 Mathematical model of dual negative feedback regulation of JAK2-STAT5 signaling EPOR EPO SOCS3 PMC8717028__F1 Nuclear receptors modulate inflammasomes in the pathophysiology and treatment of major depressive disorder PPARG GSDMD AHR IL1B PMC8580948__F3 Inhibition of Wnt-Beta-Catenin Signaling by ICRT14 Drug Depends of Post-Transcriptional Regulation by HOTAIR in Human Cervical Cancer HeLa Cells CTCF JUN TCF4 PMC3999257__F4 NRG1 signalling and neurite formation mediators UXS1 NFKB1 REL STMN2 PRKCH PMC7005066__F1 Unfolded protein response (UPR) signaling during bacterial infection CXCR1 HEL-S-11 ATF4 EIF2A FADD PMC12031541__F1 Interaction of autonomous parvoviruses with cellular DDR factors TOPBP1 ATR RAD50 ATRIP RAD51 MRE11A BRCA1 H2AX BRCA2 ATM PMC6237163__F7 The effect of fold change with RNA-seq analysis for toll-like receptor nine signaling pathway in lung NFKB1 TLR9 IRAK1 IRAK4 MYD88 PMC6237163__F6 Result of RNA-seq mainly involves the signaling pathway SYK RAF1 TLR9 IRAK1 CCL5 TRAF6 MAPK8 CXCL8 MYD88 MAPK14 IFNG MAP3K8 FYN PRKCA MAF MAPK1 CCL3L3 CSF2 VAV3 TNF FOS HRAS MAP3K7 CCL4L2 LAT AKT3 IL2RG IKBKG BTK PLCG1 IL18 CHUK TLR7 MAP2K3 IL10 LCP2 IL12A IL13 IL4 NFATC1 IL6 IL5 GATA3 MAP3K7IP1 NFKB1 IKBKB NFKBIA MAP2K1 LYN GAB2 PMC12031541__F3 AAV life cycle and DNA Damage Response (DDR) signaling TOPBP1 ATR RAD50 ATRIP MRE11A H2AX ATM PMC4132269__F2 Vascular inflammation, NK cell/monocyte crosstalk and angiotensin II in cardiac ischemic injury CD40 CD48 RAI1 CCR2 MICA VCAM1 PMC3773046__F1 Reducing Sphingolipid Synthesis Orchestrates Global Changes to Extend Yeast Lifespan POLI FHL1 NDP PMC9023073__F7 Mechanism of Lipopolysaccharide Escaping the Intestinal Barrier in Megalobrama amblycephala Fed a High-Fat Diet CD36 MUC2 GPR78 PMC7821221__F1 Wnt5a exerts its intracellular effects by activating two non-canonical Wnt signaling pathways, or the interplay with the canonical Wnt signaling pathway WNT3A APC ROR2 LRP5 LRP6 CTNNB1 PMC6515307__F1 Mechanisms contributing to regulation of tumor clearance by effector cells CD80 IL10 APC IL2 CTLA4 PMC9367504__F8 Inflammatory Mediators in Colorectal Cancer Hepatic Metastasis NLRP3 CXCL2 IL8RB IL1B PMC9367504__F7 Inflammatory Mediators in Colorectal Cancer Hepatic Metastasis CXCL1 IL8RB MYD88 PMC6252103__F2 aspartate Beta-hydroxylase (ASPH) may affect the progression of pancreatic cancer through the activation of Notch signaling pathway PTGS2 MMP9 VEGFA NOTCH1 PMC7248261__F1 Pathophysiology of allergic contact dermatitis (ACD) IFNG APC IL1B PMC6252103__F1 Transcriptional regulation of aspartate Beta-hydroxylase (ASPH) IGF1 ASPH IGF1R IRS1 CTNNB1 PMC4250230__F4 Targeting RAF kinases for cancer therapy: BRAF mutated melanoma and beyond HGF NRAS IGF1R PMC7242326__F9 Summary of the role of AHR ligands in blocking TGFB induced collagen deposition and myofibroblast formation in Thyroid eye disease AHR PMC9367504__F1 Inflammatory Mediators in Colorectal Cancer Hepatic Metastasis TRADD TRAF2 FADD PMC9130478__F3 Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases AGO2 EGFR TAB3 IRAK1 TNF MYC TRAF6 DROSHA CCL2 IRAK4 MYD88 KDM6B CYLD PMC8102492__F7 4-1BB-p38 MAPK-Dkk1 signaling pathway in BMSCs of aged mice DKK1 APC LRP5 LRP6 PMC6063970__F4 Mapping transcripts on KEGG pathway POR ATR BAD OASL ATM PTEN HP MDM2 MTOR PMC5943174__F1 Plasticity of myeloid-derived suppressor cells in cancer STAT3 NOS2 CCL3 ARG1 IRF8 PMC6436660__F3 Bioinformatics and miR-135a-3p gene profiling predicts p38 as a targeted signaling pathway EXD3 GMPPB FAM124B FDXR ZNF768 ZSCAN18 LYSMD2 KRTAP19-5 COMMD4 ZSCAN25 CPNE1 ZNF232 FADS1 DHODH CCDC22 NAXD NOC4L KRI1 OASL USHBP1 EIF2D ACSF2 ZNF174 MZF1 WDR83 GPSM1 PMC6998289__F2 Small peptides encoded by circRNAs and lncRNAs regulate tumor invasion, metastasis, and proliferation DCP2 EDC4 GSK3B CTNNB1 PMC6998289__F1 Small peptides encoded by circRNAs and lncRNAs regulate tumor proliferation USP28 FBXW7 PAF1 PCNA DTL SOX2 POLI CCND1 PMC4791269__F5 Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network PCNA AKT3 MTOR CS CCNA2 ARHA CDC34 MYC HRAS FBXW7 CDK6 RALA FOXO3A IKBKB MDM2 CDK4 PMC3216974__F7 S6K1 and 4E-BP1 Are Independent Regulated and Control Cellular Growth in Bladder Cancer RHEB TSC2 TSC1 PIR PTEN PMC3579607__F2 Mechanisms underlying modulation of HER2-directed therapy cardiotoxicity through aerobic exercise ERBB3 NRG1 ERBB4 ERBB2 MTOR SRC GATA4 PMC2820587__F3 AURKA interactions BAX AURKA MDM2 CCND1 CTNNB1 CLDN1 PMC3579607__F1 Mechanisms underlying HER2-directed therapy cardiotoxicity ERBB3 NRG1 ERBB4 ERBB2 MTOR SRC GATA4 PMC8264427__F3 Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes CHI3L1 CCR2 IL8RB MTOR CCL2 CXCL8 IL13RA2 PMC2704458__F2 Histone Acetylation in Drug Addiction CDK5 FOSB HDAC5 PMC4447103__F1 Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy STAT3 LEP TRADD LEPR MTOR SOCS3 TNF NR1C1 POMC NPY GOPC AgRP TRAF2 UNK PMC8124433__F10 Meta-Analysis of Methamphetamine Modulation on Amyloid Precursor Protein through HMGB1 in Alzheimer’s Disease IL1R1 HMGB1 FAS AGER ADRA2A BACE1 MMP3 APP PMC4036091__F2 Schematic diagram representing the hypothetical mechanisms of the insulin-dependent systemic (I) and insulin-independent direct (II) effects of metformin in the endometrium TSC2 TSC1 PTEN IGF1R MTOR IRS1 PMC11532857__F5 MiRNAs in metastasis of HCC STAT3 SRPK1 ADAM10 CTNNB1 PMC11532857__F4 MicroRNAs in EMT process STAT3 SRPK1 IRF1 MTOR PMC12180341__F9 Potential mechanism by which PTS alleviates renal fibrosis SMAD2 PTS PMC5369137__F1 Metabolic pathway of clopidogrel and its targeted receptor CYP1A2 CYP2B6 CES1 CYP2C19 CYP2C9 CYP3A4 PMC8863767__F11 Synergistic Effects of Toll-Like Receptor 1/2 and Toll-Like Receptor 3 Signaling Triggering Interleukin 27 Gene Expression in Chikungunya Virus-Infected Macrophages IL15 IL27RA IRF1 IRF3 IRF7 CCL2 TLR1 TLR3 TLR4 EBI3 CCL7 ISG15 JAK1 PMC11532857__F7 MiRNAs regulating angiogenesis in HCC HGF DLL4 PDGFRA MMP2 PMC11532857__F6 MiRNAs regulating glycolysis in HCC HEL-S-133P HK2 PTEN MTOR PMC11526712__F1 Study workflow: Four differential microbial strains were found in the fecal microbiota of Laiwu pigs and Lulai black pigs RHEB STAT1 TSC2 TSC1 PIGS CD163 PMC11526712__F8 Pathways through which E RHEB TSC2 TSC1 PTEN PMC2667750__F8 Proposed pathway for polyoxin biosynthesis POLL POLM NHS POLK POLG POLI POLE PMC3554122__F1 Summary of checkpoint factors MRC1 RAD17 PMC12115143__F1 Integrative scheme of multistep phosphorelay in plants RRAS RAC3 PMC7156858__F2 Suppressive role of MIR143‐3p in rat sarcoma (RAS) signaling pathway HRAS NF1 EGFR NRAS MTOR KRAS PMC4187614__F2 Rho GTPase signaling pathways regulating neuronal survival BAX BAD PTEN RHO PMC8304872__F7 Apoptotic and Non-Apoptotic Modalities of Thymoquinone-Induced Lymphoma Cell Death: Highlight of the Role of Cytosolic Calcium and Necroptosis RIPK3 CASP9 HMGB1 CASP8 CAD ORAI1 H2AX STIM1 CASP3 RIPK1 XBP1 FADD PMC6901991__F1 Schematic diagram of a cell with insulin/IGF signaling cascades depicted BAD IGF1 IGFBP2 IGFBP7 IGF1R MTOR IGF2 M6PR PMC8518101__F2 When to Measure Plasma Homocysteine and how to Place it in Context: The Homocystinurias CBL CBLC PMC7731760__F4 Metabolic pathway of D-mannitol in O PFKFB4 PFKFB2 PMC9277484__F4 Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland PAX3 TBX2 LRP4 PYGO2 LRP6 NRG3 HOXC6 TNF GATA3 MSX1 TBX3 LEF1 MSX2 GLI3 PMC10610064__F1 ABL Kinase Activation and Signaling in Solid Tumors DAB1 TRIO ABL2 NQO1 RHO MTOR SRC CXCR4 CCND1 PMC7731760__F5 Metabolic pathway of cordycepin in O PURA RRM1 RRM2 ADK PURB PMC9277484__F3 Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland ERBB4 SUFU BMP4 PTCH1 NRG3 SMO IGF1R FGF10 EDAR TNLG7C IRS1 GLI3 PMC3945866__F6 In addition to the known pathways that activate hepcidin expression, we show that Ras/RAF-triggered signals and the mTOR pathway are involved in hepcidin suppression CREBBP YY1 IL6 MTOR FOS PMC2270259__F3 Central metabolism MAL CIT PMC10889086__F1 Bruton’s Tyrosine Kinase Inhibitors: Recent Updates CD80 CD69 CARD11 CD5 CD22 BLNK CD19 MYD88 BTK BCL10 BCR PLCG2 LYN PMC7988095__F2 AhR signaling pathway AHR AHRR PMC8744248__F3 Recent advances in systemic therapy for hepatocellular carcinoma HEL-S-92n APC PMC3272705__F1 Subcellular itineraries of paradigmatic substrates of ubiquitin-dependent sorting pathways CBL OSM USP2 EGFR PMC11906681__F3 Targeted therapy in pediatric central nervous system tumors: a review from the National Pediatric Cancer Foundation RHEB TSC2 TSC1 IGF1 TBC1D7 IGF1R MTOR PMC8539723__F3 Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis SOCS1 STAT3 SOCS3 PMC6844630__F1 Mechanisms of action of miR-21 showing the regulation of the WNT signaling pathway in NAFLD mice GSK3B LRP6 CTNNB1 PMC11906681__F2 Targeted therapy in pediatric central nervous system tumors: a review from the National Pediatric Cancer Foundation SUFU PTCH1 SHH SMO GLI3 PMC5718065__F8 Schematic diagram illustrating potential interactions and changes in Ten-m3 KOs EPHB1 EPHA7 ZIC2 PMC7438890__F1 Effect of local RAS on normal and leukemic hematopoiesis, as well as plasticity and systemic circulation, are shown () STAR CTSA PMC7204005__F3 miRNA-28-3p promotes cell proliferation through the MAPK signaling pathway and participates in the regulation of diabetes CDC42 JUN TRADD OSM MAPKAPK2 TNF TRAF6 RAC1 HSF1 BCL2 GRB2 SRC TRAF2 PMC5838831__F4 Sinalization cascade for genesis of medulloblastoma SHH MB CTNNB1 PMC7204005__F5 miRNA promotes signal transduction and glucose protein binding through the TGF-beta signaling pathway and participates in the regulation of diabetes MAP3K7IP1 SMAD2 SMAD6 SMAD4 ATF2 ARHA GRB2 SKI PMC5833345__F7 FBXL10-promoted DLBCL cell proliferation BCOR PRC1 PCGF1 BCL6 PMC7204005__F4 miRNA-28-3p promotes cell proliferation and migration through the IGF signaling pathway and participates in the regulation of diabetes CRK BAD IGF1 GSK3B PTEN IGF1R GRB2 MTOR IGF2 EIF4E PMC6457250__F5 Metabolic control of macrophage function STAT3 BMP4 IRF1 IL1B PMC9086853__F12 Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells HEL-S-304 HEL-S-68p HEL-S-162eP ENO1 HEL-S-87p HEL-S-30 PFKM PSPH HEL-75 PMC1124928__F4 Coagulation, fibrinolysis, and angiogenesis in cancer TF TFPI PLG PF4 PMC5739687__F3 PPI network of proteins (A) up- and (B) down-regulated in renal oncocytoma SLC25A5 AK3 CYCS PCCA FXC1 PLEKHA7 GPX3 HEL-S-51e KRT19 TSFM CKMT2 RNASET2 HEL-S-29 CD9 UQCRH PC MDH2 PSME2 GLB1 NNT MRPL11 GOT2 MRPL53 ATP6V1F ACADS SNCA DUT ITGB3 TFAM SDHA PKP4 OGDH PALLD HEL110 ENO1 CTNNA1 PPIF NDUFB9 LYZ SNRPC TIMM44 HEL-S-97n IGF2R UQCRB ECHDC2 PRDX5 G3BP2 OGDHL HEL-S-108 VWF DCXR ACO2 ASPN S100A10 TLN2 HEL-S-70p LRPPRC PHB2 MTHFD1 DLAT MFAP2 ALDH7A1 DHRS4 LCP1 BDH1 CHCHD4 NDUFV2 EPB41L3 RAB11FIP5 SLC25A3 NDUFA10 COX17 NDUFS3 RPS11 SLC25A4 COX6A1 MRPS18A CHCHD2 ATP6V1B1 NDUFS6 CNN2 MRPL17 PRELP DNAJC19 DCN GAA COA6 SLIRP RPS4X ANXA2 MRPL43 MRPL14 VCAN PCK2 HBD APOB CHDH DLD AKAP12 NDUFS1 COX6B1 HEL-S-22 GFER SSBP1 EHHADH FXN ISCU ASL COX7C NDUFS8 DPYSL3 CS SUOX UQCRQ ITGAV MYLK F2 HEL-S-14 TXN2 UQCRC2 ITIH4 JUP HSP90AB1 CNDP2 GMPR2 TIMM9 AMBP TIMM13 CHCHD3 APOA2 CD44 HEL-S-8a HEL-S-130P NDUFA2 PPA2 PMC7988095__F1 Intestinal stem cell compartment and molecular cascades related to AhR signaling EGF EGFR APC GRB2 MTOR GPR49 HES1 PMC3394958__F6 Schematic showing observed protein level alterations in VSCC proteome in the context of HPV infection STAT1 FAS CASP14 PRKDC EGFR MX1 OAS3 OAS2 FADD PMC7938726__F1 Diagram of osteoimmunology and potential regulatory sites of TCPTP CXCL12 PREB PMC5413910__F4 TNF-induced canonical NFKB and apoptosis pathways SHARPIN TRADD OTULIN TNF CYLD TRAF2 FADD PMC6497758__F3 Proposed Schematic diagram of the interaction of Mda5 with LGP2 in the RLR signaling pathway TBK1 MAVS IRF3 IRF7 PMC6497758__F2 Proposed Schematic diagram of Mda5 signaling pathway in Teleost based on a Mammalian Model TBK1 MAVS IRF3 IRF7 PMC7672768__F2 Protein-protein interaction (PPI) network constructed using the STRING online database and Cytoscape software HEL-S-117 TNC CXCL12 AOX1 PTN SPARCL1 RECK LAMC2 CFD GAS PLAUR COL14A1 PRNP KRT4 ALDH3A2 TFRC PTHLH HEL-S-75 FST CLU DPT APP HCTP4 PMC5601664__F7 SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cells CDC42 STAT3 SUMO2 SENP1 SENP6 SENP2 SENP7 RAC1 SENP3 PMC8229713__F7 Two-way rectification method for identifying differentially expressed genes by maximizing the co-function relationship IFNG CD3D CASP8 NLRP3 CASP3 NOD1 TNF IL1B MYD88 PMC8308893__F6 Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice TREM2 CDK5 BACE1 GSK3B ARG1 PMC1993861__F7 Model summarizing the hypothesis on narciclasine-mediated apoptosis BAX FAS FADD PMC11922768__F8 The molecular architecture of plaque-associated axonal spheroids NAPA CANX ATP8A1 PPP3CA CAMK2A PIK3R4 AP2A1 RTN1 UBB RYR2 GAA SLC8A2 ATP2B2 SYT11 MYH10 APOE SPTBN1 NTRK2 CTSA NCKAP1 TUBB RHEB VPS35 KIF21A CALM1 ARHGEF7 ENO1 GRIA2 ATP2B1 VAMP2 HEL-S-62p ATP2B3 ARCN1 ARPC3 GANAB MTOR PSMD2 PSMD1 CLU SYP G3BP2 SYNGR1 APP DYNC1H1 LAMTOR1 GRIA4 CLTC RRAGA VPS16 TUBA1A ACTN1 GABRB3 LAMP2 HEXB HEL-S-130P RTN3 ATG9A VPS41 SNAP25 SYT1 PMC4135307__F1 Adaptive immune resistance of acute myeloid leukemia (AML) IFNG ICOS PMC7865845__F2 Role of the discussed NLRs in type I interferon signaling TBK1 CGAS MAVS NLRP11 TLR9 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 RIPK2 NLRP6 DHX15 TLR4 NOD2 NOD1 TLR7 NLRP14 NLRP2 IRF3 IRF7 IRF8 NLRC4 NLRP12 NLRX1 TLR3 NLRC3 PMC4036234__F2 Cargo recognition and packaging in selective macroautophagy LGALS8 SQSTM1 OPTN PEX3 CALCOCO2 PMC9696247__F1 Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia PINK1 FGF21 BNIP3 PMC3539299__F1 The phosphatase and tensin homolog deleted on chromosome ten (PTEN)/Akt pathway and its relationship to the androgen receptor (AR) based on the results of three papers published recently by the laboratories of Charles Sawyers, Damu Tang and Hong Wu FKBP5 EGR1 MAN2C1 EZH2 PTEN MTOR PMC10215262__F2 Studies related to the role of the Wnt/Beta-catenin signaling pathway in Acute Myeloid Leukemia WNT10B SOX17 KMT2A FOXM1 FZD4 DKK1 WNT1 WNT2B WIF1 RUNX3 PMC3423951__F1 The interplay between pituitary hormones and main signaling pathways of the IGF system in thyroid, adrenal and ovary cancers TSHR GRB2 MTOR FSHR IRS1 PMC3483025__F1 Metabolic pathway of tetrapyrrole biosynthesis in plants POR CPO FECH UROD UROS PMC10215262__F1 Canonical Wnt pathway CDC42 ROR1 BCL9 JUN APC ROR2 LRP5 LRP6 ARHA CTNNB1 PMC9368769__F4 Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases GSK3B CTSK ATP6V0D2 OSCAR DAP TRAF6 CTNNB1 PMC12128263__F2 Three metabolic pathways in cells ENO2 GLS HEL-S-133P MTOR PMC6693056__F16 Summary of key estrogen-dependent mechanisms in endometriosis SF1 HSD17B2 GATA6 IL1B PMC12128263__F4 Schematic diagram of cysteine metabolism SLC3A2 GPX4 SLC7A11 PMC3929246__F1 Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment TIRAP TLR9 CD14 IRAK1 TLR5 IRF3 IRAK2 TRAF6 IRAK4 MYD88 LPA TLR1 TLR3 TLR4 TLR8 TLR7 PMC8380544__F1 Novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder TLR3 CRABP1 TLR9 TLR8 TLR7 MTOR PMC6297399__F5 String pathway enrichment analysis revealed strong associations (P=0.007) of the identified prognostic genes (colored nodes) SMARCC1 EGF HGF EGFR PTPN11 KIT KRAS KITLG MDM4 SMARCC2 ACTL6A PDGFRA MDM2 SMARCA4 PMC5904546__F6 Cardiomyocytes and fructolytic pathway are strongly affected in P7 hearts TG HK2 PFKFB2 HEL-S-87p PMC2805044__F1 The Akt/mTOR pathway in tobacco-carcinogen induced lung tumorigenesis RHEB TSC2 BAD TSC1 PI3 PTEN KRAS PMC5904546__F5 Comparative analysis of differentially expressed proteomic and differentially regulated metabolomic data HADHB ACSL1 ACSL5 HEL-S-5 HSD17B10 PMC9371865__F8 LTBP2 Knockdown Promotes Ferroptosis in Gastric Cancer Cells through p62-Keap1-Nrf2 Pathway LTBP2 KEAP1 GPX4 PMC7870784__F4 Depiction of MAPK signaling pathway dysregulation and miRNAs in the KEGG database MIA ALK NF1 IGF1R PMC7870784__F3 Depiction of the MAPK signaling pathway in the KEGG database SAA1 NLK PMC7870784__F5 Model illustrating the miRSNP → miRNA → risk gene → pathway effect PSD IGF1 PSD JAK1 BDNF PMC2707344__F4 Metabolic implication of leaf mitochondria during water stress C6 MAL ATM PMC6762067__F1 Ten simple rules to create biological network figures for communication ARAF SPRY2 EGF NDN F2 EGFR NRAS PRKCZ APP ARC INS UBB PMC6305291__F5 Glucose catabolism pathways and transport systems of strain A4B-17 NONO PTS PMC5842210__F1 Pathogenesis of diabetes and its complications, reflecting where CCN proteins may take part CCN5 CYR61 CCN3 CTGF PMC3372250__F5 The Hsp90 folding cycle PPT1 STIL CDC37 PMC4197103__F1 Necroptotic signaling in adaptive and innate immunity RIPK3 TRADD TLR3 MLKL TLR4 RIPK1 TNF CYLD TRAF2 FADD PMC8967065__F5 Instructive cues establishing PCP during kidney development WNT9B WNT7B PMC4970921__F1 Microarray and bioinformatics analysis of tendon fibroblasts treated with PRP or PPP ERCC1 HEL-S-101 GADD45G HEL-S-62p MSLN MMP10 PLSCR1 MMP9 OLFML2B SERPINE2 MMP3 CCDC80 LCN2 CEBPB PMC8967065__F4 Relationship between PCP and cystogenesis FZD3 VANGL1 PMC8037356__F7 The signaling pathway in tested melanoma cells RICTOR ULK1 HEL-S-28 PTEN MTOR EIF2A EIF4E PMC8406487__F4 6‐Shogaol induces apoptosis in acute lymphoblastic leukaemia cells by targeting p53 signalling pathway and generation of reactive oxygen species NGF CAD CASP2 TNF HRK TRAF2 DIABLO FADD PMC8967065__F3 PCP signaling in kidney development ROR1 FAT4 CELSR1 GDNF ROR2 PTK7 PCDHJ WDPCP DCHS1 FZD8 FZD4 FZD3 VANGL1 CD2AP FAT1 WNT4 RET PMC10385932__F1 Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies SOCS1 ATF3 IL2RB EGR1 JAK3 IL2RA ITK JAK1 PMC5412393__F4 Potential contribution of protein disulfide isomerase (PDI) and various environmental factors in regulation of the TF-fVIIa complex on the surface of epithelial ovarian cancer (EOC) cells TF TFPI CA9 PMC9048014__F5 Candidates for Biomarkers in Bipolar Disorder: A Proteomic Approach through Systems Biology VWF CD59 FH CPB2 HEL-S-62p PLG CR2 CS TFPI F2 F10 F3 PC A2M PMC9182524__F3 Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer BAD HEL-S-68p PTEN PMC9182524__F6 Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer SOX9 ADAM10 CCND1 NOTCH1 PMC4904147__F1 Antigen processing through MHC I molecules TAP1 B2M TSN TAP2 PMC3367714__F1 ATM/ATR DNA-damage response pathway ATR ATRIP WEE1 ATM PMC7341754__F6 Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets CEBPA NR2A1 APC CTNNB1 PMC4868905__F2 Metabolic changes triggered by ischemic insult and possible evolutions of the injury with the crosstalk between chemokines CXCL2 CCL5 CCL2 TNF CXCL8 CXCL3 PMC10197881__F9 Proposed mechanisms STAT1 CCR2 HERC6 XAF1 PMC4905223__F1 OGT links cancer cell metabolism and cell survival via regulation of HIF-1A OGA OGT HEL-S-133P PMC11575457__F1 [KRAS signaling pathway and targeted therapeutic agents SOS1 EGFR GAB3 IGF1R GRB2 MTOR KRAS GAB2 PMC3776465__F2 Functions of the proteins encoded by the genes mutated in primary lymphedema cluster around a central molecular pathway: the VEGFR3 signaling PROX1 GATA2 VEGFC KIF11 FOXC2 CCBE1 FLT4 SOX18 PMC9182524__F7 Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer BAX ATR CDK6 ESD CDK2 BCL2 MDM2 PMC9506679__F2 Emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment IRF3 TRIM21 HDAC6 PMC3539252__F3 Upregulated HCV gene signature is enriched for interferon (IFN) pathway genes IRF9 MX2 RSAD2 OAS3 LY6E PMC4443295__F4 Schematic overview of the 7TM receptors judged to be either stimulating (in green to the right) or inhibiting (red or orange to the left and top) ghrelin secretion directly on the ghrelin cell CASR SCTR RAMP1 GIP FFAR2 GIPR PMC5778124__F6 Inhibitory nucleotide-binding oligomerization domain (NOD)-like receptors put the brake on NFKB activation via canonical and non-canonical pathways CD40 RELB IRAK1 TRAF3 TRAF6 TNF MYD88 PMC8638432__F12 Exosomal microRNA-107 reverses chemotherapeutic drug resistance of gastric cancer cells through HMGA2/mTOR/P-gp pathway HMGA2 GC MTOR PMC4299512__F1 Select upstream regulators and downstream effectors of mTOR signaling RHEB TSC2 TSC1 SGK1 GSK3B PTEN PMC2892366__F10 A model for the function of GCN2, ATF4, ASNS and Asn in conferring tumour cell protection from microenvironment stress SLC1A4 ATF4 ASNS EIF2A PMC5571822__F1 EGFR pathway and mechanism of action of osimertinib.Abbreviation: EGFR, epidermal growth factor receptor; TGF, transforming growth factor STAT3 EGF TGFA MTOR JAK1 PMC6830765__F1 NFKB pathway and the inhibitory effect of various alkyl nitrate N-Aryl Piperamide on NFKB translocation and COX-2 function NAPA IL1B MYD88 PMC5630446__F2 Bladder cancer stem cells: clonal origin and therapeutic perspectives SUFU GSK3B SHH GLI3 PMC8863469__F16 29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses APC PTEN MTR PMC4747503__F5 Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea MYO7A CS PMC7068531__F2 JAK-STAT-3 signaling pathway STAT3 SOCS3 CCND1 PMC3561841__F1 Why stress is BAD for cancer patients BAD PTEN MYC PMC6230580__F2 Snail and cell-cycle progression PCNA CCND2 CCND1 CTNNB1 PMC5630446__F4 Bladder cancer stem cells: clonal origin and therapeutic perspectives APC GSK3B CTNNB1 PMC12081031__F1 Schematic displaying the unfolded protein response signalling pathway ATF4 XBP1 PMC4639861__F9 Model for Grhl2 function in coordinating differentiation and morphogenesis of airway epithelium MCIDAS MYB FOXJ1 RFX2 NOTCH3 SMAGP ZNF750 PMC11092382__F2 Antitumor effects of sophocarpine through multiple signaling pathways CDH2 PTEN MMP9 MTOR HES1 PMC12081031__F3 The promotion of EMT by XBP1 ZEB2 XBP1 PMC5537069__F6 Schematic representation showing downregulation of miR‐205 by ErbB2 signaling via Ras/Raf/MEK/ERK pathway ERBB2 PMC8959892__F2 Pyroptosis-Related Inflammasome Pathway: A New Therapeutic Target for Diabetic Cardiomyopathy TXNIP TLR4 ARC SIRT1 MYD88 PMC4350284__F5 Activated SFK interfere with dimerization and nuclear translocation of pSTAT5A in BCR-ABL expressing cells BCR EPO GAB2 PMC8224095__F1 Pharmacological Protection against Ischemia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway FYN KEAP1 GSK3B PMC3511450__F5 Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways CD40 C6 STAT3 RAF1 MAP3K10 MAP3K13 MAP3K12 JAK3 MAPKAPK3 PRKCZ MAP3K11 TRAF6 MYD88 MAP3K2 MAP3K8 MAP2K6 PDPK1 PRKCA BTC MAP3K15 SRC C7 CRKL MAPKAPK2 INPP5D RPS6KA4 MAPKAPK5 IL1A TNF DOCK1 IRS1 ERBB3 CRK PRKCI MAP3K1 PRKCQ TRAF5 MAP3K7 MAP3K5 GRB2 EGF TNFRSF1B TGFA MAPK11 EGFR IKBKE RPS6KA1 BRAF MTOR IKBKG PRKCH PRKCB IL1R2 IL1R1 MAP2K4 CHUK TIFA CAMK4 MAP2K3 IL1B ECSIT DAG1 ERBB4 TLR5 IL6 RAC1 NRG1 C2 RPS6KB1 IKBKB ERBB2 IL6ST INPPL1 JAK1 MAP2K1 MAP2K2 RPS6KA5 MAP3K6 TRAF2 GAB2 PMC10239578__F4 Differential molecular pathway expression according to chemotherapeutic response in ovarian clear cell carcinoma NGF BAD ITGB8 PDGFRA FGF9 PTEN MDM2 GRB2 MTOR RELN COL2A1 PMC6698587__F1 Regulating mechanisms of UCA1 in multiple human cancers MMP7 HMGB1 AGO2 FGFR1 BCL2 ZEB2 RAB22A CREB1 SOX4 CTNNB1 PMC3303469__F1 Hypoxia inducible factor (HIF) pathway EP300 HIF1A VHL PMC10884928__F1 NAD metabolic therapy in metabolic dysfunction-associated steatotic liver disease: Possible roles of gut microbiota NRK NAPRT HEL-S-90n NAMPT NADSYN1 PMC3013804__F3 Case study of the discovered phosphorylation networks associated with insulin signaling pathway CDC42 ZAP70 EGF JUN BAD RAF1 SHC1 SOS1 MAPK8 MYC RAC1 IRS1 MAPK14 INSR PAK1 MAPK7 ERBB2 GCK GRB2 JAK1 PMC3562241__F6 Ihh and Runx2/Runx3 Signaling Interact to Coordinate Early Chondrogenesis: A Mouse Model PTCH1 IHH SMO RUNX2 RUNX3 PMC10884928__F3 Prevotella along with NR supplements improving the signaling pathway of BCAA metabolism in MASLDNAD precursor supplements can affect fatty acid oxidation and lipid synthesis as well as the TCA cycle and insulin sensitivity UCP2 FAS BCKDK UCP3 NAMPT SIRT1 PMC4646490__F8 Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway GAA EGF EGFR SRC PMC7896234__F1 Mechanisms underlying microglial response to peripheral inflammation.(A) Schematic representation of the signaling pathway underlying changes in microglial Ca2+signaling, induced by peripheral inflammation TRPM2 NLRP3 IL1B PMC10669501__F2 Interplay of NRF2 in Kupffer cells and HSCs during the progression of chronic liver disease TGFBI KEAP1 SMAD2 PMC5974094__F1 Potential immune mechanism involved in vaccination with G10E-CS APC CS PMC9434901__F9 Oleuropein inhibits invasion of squamous cell carcinoma of the head and neck through TGFB1 signaling pathway SMAD2 SMAD4 PMC9011134__F7 Delivery of Basic Fibroblast Growth Factor Through an In Situ Forming Smart Hydrogel Activates Autophagy in Schwann Cells and Improves Facial Nerves Generation via the PAK-1 Signaling Pathway BAX PAK1 BCL2 ATG5 PMC11695430__F1 Protein signaling pathway involving both DAMPs and selected cytokines in ICD modulation HMGB1 IL12A IL17A IL6 TNF CXCL10 CXCL8 HEL-S-99n IFNG HSPA4 IFNB1 IL12B IL23A PMC6019623__F2 Synovial cell metabolism and chronic inflammation in rheumatoid arthritis HIF1A MTOR MYC PMC6224991__F1 Axels and brakes in the immune reaction ZAP70 CTLA4 PMC7582690__F2 PI3K/Akt signaling pathway converges to facilitate the progression OS AXL IGF1 CX3CR1 GPNMB MTOR SRC ZIC2 PMC3342049__F2 Autophagy within antigen donor cells and cross-priming HEL-S-92n SYK TLR3 APC PMC6466304__F2 Diagram of major H4K20-related proteins and their proposed role in DNA double stranded break (DSB) repair FANCD2 RNF168 SETD8 KMT5C RNF8 KMT5B NSD2 PHF2 MDC1 PMC4891302__F6 Co-targeting Androgen Receptor Splice Variants and mTOR signaling pathway for the Treatment of Castration-Resistant Prostate Cancer UBE2C MTOR PMC7194552__F4 Phosphatase and tensin homolog (PTEN), a p21-activated kinase (PAK)1 blocker, interferes with coronavirus-induced PAK1-dependent signaling pathway leading to lung fibrosis PAK1 PTEN CCL2 ACE2 PMC11063341__F1 Mechanism of Hippo pathway and the hippo targets of ncRNAs TEAD2 TEAD3 VGLL4 TEAD4 PMC3693466__F1 Insulin Signaling: Inositol Phosphates Get Into the Akt PI3 PTEN IP6K1 IRS1 PMC6767532__F1 Cyclooxygenase (COX) pathway and prostaglandin E2 (PGE2) signaling COX1 PMC6695051__F4 Result of the exploration of HTR1A functions involved in biological process pathways using the STRING database (http://string-db.org/newstring) RICTOR FOXO1 FOXO3A 5HT1A GSK3B HEL-S-28 PTEN MDM2 MTOR PMC4202123__F1 Structural basis for cancer treatment decisions EGFR PTEN GRB2 MTOR PMC10041595__F5 NRF1 Regulates the Epithelial Mesenchymal Transition of Breast Cancer by Modulating ROS Homeostasis CDH2 HEL113 TJP1 SOX2 PMC2806370__F3 Pathway deregulation in ovarian cancer RARA ACD SMO PMC4202123__F3 Structural basis for cancer treatment decisions ERBB3 HGF EGFR ERBB2 MTOR PMC6484897__F1 TLR signaling and downstream molecules TLR1 IRF3 MYD88 PMC2806370__F2 Cell cycle pathway gene expression BUB1B GSK3B SMAD4 TBC1D8 CCNA2 SKP2 PLK1 PTTG2 CCNB3 RB1 CDK6 CCNE1 WEE1 MDM2 ESPL1 ANAPC10 MPEG1 TGFBR3 SMC1A ANAPC1 CDKN1B CDK2 CDC27 GADD45A ATR TGFB1 CDC20 ANAPC7 PCNA ANAPC11 CDC6 CDC23 APC2 CCNH TGFBR2 CCND2 CHEK2 ATM CCNB1 CCND1 YWHAG CDK4 CCND3 RBL1 PTTG1 CCNE2 PKMYT1 PRKDC CHEK1 BMP2 SKP1 EP300 UBE2F PMC4264984__F5 Putative mechanism for EGCG-conducted cardioprotection against H2O2-induced oxidative stress through the Akt/GSK-3B /caveolae pathways in cultured H9c2 cells SDHA ALDH2 INPP4B ENO1 HEL-S-97n HNRNPK CCND1 PMC3193288__F1 Innate immunity against RNA viruses in mammals TBK1 MAVS TLR3 IRF3 PMC6773405__F4 Focal adhesion pathway with enriched genes DOCK1, FLNB, FLT1, FYN, IGF1R, PPP1R12A HEL114 VASP PTEN CHAD AGA RELN FLNA PMC6011061__F1 The Keap1/Nrf2 pathway and its epigenetic modification by SFN KEAP1 NQO1 MAF SFN PMC7560597__F5 Complexity of interactions between autophagy machinery and the cGAS–STING pathway TBK1 CGAS ULK1 WIPI2 IRF3 PMC7560597__F4 Interplay between the cGAS–STING signaling pathway and pyroptosis CGAS AIM2 IL1B PMC7560597__F3 Initiation of necroptosis by cGAS–STING signaling RIPK3 MLKL IFNAR1 RIPK1 TNF PMC7560597__F2 Interplay between the cGAS–STING signaling pathway and apoptosis BAX TBK1 CGAS IRF3 APAF1 PMC7560597__F1 Activation of the cGAS–STING signaling pathway to drive innate immune responses TBK1 CGAS IRF3 TNF PMC11091639__F8 PD-L1 regulatory signaling pathway [23] STAT1 PTEN TRAF6 MYD88 PMC8414998__F2 Neuroinflammation in Autoimmune Disease and Primary Brain Tumors: The Quest for Striking the Right Balance STAT3 IL10 CSF1 TGFA IL13 IL4 IL6 IRF4 TNF IFNG STAT1 AHR IL2 PMC5323854__F7 Putative mechanism of necroptosis in the development of intestinal injury following intestinal I/R HMGB1 MLKL TLR4 PMC3457779__F1 The MAPK cascade activation and potential cross talk signals BAX JUN BAD FYN BCL2 GRB2 FADD PMC4926156__F2 VacA interferes with T-cell activation and proliferation by manipulating the T-cell receptor pathway and the cell cycle JUN LAT FOS LCK PMC7756807__F2 Energy‐generating regulators in Tregs TSC1 PTEN HIF1A FOXP3 MYC PMC9598867__F1 Redox-Regulation in Cancer Stem Cells FZD2 GSK3B SOX2 VEGFA ASCL2 AXIN2 CTNNB1 CD44 HMOX1 HEL-S-2a SHH SMO GPR49 CCND1 PMC9537744__F1 Association between gene polymorphisms in the cyclophosphamide metabolism pathway with complications after haploidentical hematopoietic stem cell transplantation GSTM1 CYP2C19 CYP3A4 PMC12096525__F11 a) LDH-mediated NT3 delivery enhances spinal cord repair: axonal regeneration and functional recovery in a murine model CDH2 PIEZO1 SOX1 MSC MAP2 PAX6 PMC2806300__F8 Reversal of EMT induced by TGFB1 SMAD2 SMAD4 ZEB2 ARHA PMC9598867__F2 Redox-Regulation in Cancer Stem Cells GSTM4 HMOX1 GSTM2 ABCC1 GSTM1 GSTM3 KEAP1 NQO1 GCLC SHH PMC7291237__F1 Late phase of the HIV-1 replication cycle SP1 PC SP2 PMC10970097__F1 The PI3K/Akt/mTOR signaling pathway RHEB BAD TSC1 PTEN MDM2 KRAS PMC3695748__F6 Schema of regulatory mechanisms of endothelial atherosusceptibility discussed in the text KLF4 KLF2 VCAM1 PMC4980327__F1 Molecular alterations cause metabolic switching in cancer cells and severe metabolic changes in the tumor microenvironment GLS PTEN HIF1A TIGAR SCO2 MTOR MYC PMC5992820__F1 Simplified schematic diagram of the pathways described in this study ERBB3 TSC2 TSC1 ERBB2 IGF1R IRS1 PMC4725600__F1 Mdm network and its regulation of p53 activities: a rheostat of cancer risk MDM4 RAD50 MRE11A MDM2 MYC PMC3473263__F4 Sample regulation summary diagrams for E CRP GIN1 CP PMC6141435__F1 Hippo signaling pathway in Mammals FAT4 RASSF6 AJUBA NF2 PMC3278889__F6 CD40 signaling to the alternative NFKB pathway CD40 RELB TRAF3 PMC3278889__F5 T-cell receptor (TCR) signaling to NFKB BCL10 CARD11 PC PMC3278889__F4 TLR4 signaling to NFKB MAP3K7IP1 TLR4 MAL IRF3 TRAF6 MYD88 PMC9208314__F1 Translation initiation pathway EIF4B ELF1 SUI1 ELF2 EIF5 EIF5B ELF5 ELF3 PMC8038076__F8 GR-SC65 suppresses the PM-induced ROS-dependent apoptosis pathway APP TRAF6 TRAF2 PMC12222324__F3 FOXM1 involved in chemoresistance in ovarian cancer FOXM1 SP1 MTOR PMC7933973__F1 Current mechanisms underlying KLF5 effects on kidney diseases LPA FBXW7 EGR1 HEL-S-62p S100A8 KLF5 S100A9 CCND1 RAC1 YAP1 CDK4 PMC12222324__F2 FOXM1 in ovarian cancer development KRT5 FOXM1 DLX1 HK2 KIF20A SMAD4 KRT7 CCNB1 PLK1 SKP2 CDC25B CTNNB1 PMC2518073__F8 Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer RHEB TSC2 TSC1 RAF1 IRS1 PMC10276824__GA FOXO1 regulates Th17 cell-mediated hepatocellular carcinoma recurrence after hepatic ischemia-reperfusion injury FOXO1 PMC8881489__F1 Radiotherapy: Brightness and darkness in the era of immunotherapy CXCL9 CXCL11 CD80 HMGB1 CGAS CXCL10 PMC3683810__F8 Proposed model of p38 MAPK regulation of mRNA translation EEF2K DHH EIF5A EEF2 IL1B EIF4E PMC8555654__F6 Semaphorin3F Drives Dendritic Spine Pruning through Rho-GTPase Signaling NRCAM TIAM1 ROCK2 LIMK2 PAK1 LIMK1 ROCK1 ARHA RAC1 PMC8783172__F4 What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability? IRAK1 IRF3 IRF7 TLR7 TRAF6 MYD88 PMC4017430__F1 Leptin receptor signaling STAT3 SOCS3 PMC8365877__F3 Immunological Involvement of MicroRNAs in the Key Events of Systemic Lupus Erythematosus CD40 BAX CD80 BCR CD180 CD19 PTEN LYN PMC7243768__F2 SARS-CoV-2 enters into the host cell via binding with the cellular receptor ACE-2 TIRAP APC TRAF3 CXCL10 TRAF6 IRAK4 PMC6629926__F1 The role of ARG1 and IDO1 in neoplasia and autoimmunity IDO1 AHR ARG1 SRC PMC9030544__F4 Proteomic Analysis of Endometrial Cancer Tissues from Patients with Type 2 Diabetes Mellitus ACTN1 SPTBN2 PMC8900363__F7 Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway BMP15 FZD4 EGFR AMH MTOR SRC NOBOX PMC2782081__F1 An overview of miRNA biogenesis RAN DGCR8 DICER1 DROSHA PMC3278592__F3 The pleiotropic effects of erythropoietin in infection and inflammation BCR EPOR EPO PMC9138110__F11 Transcriptome Analysis of Breast Muscle Reveals Pathways Related to Protein Deposition in High Feed Efficiency of Native Turkeys HEL-S-182mP PHGDH CD36 PSPH PMC7139589__F3 Extracellular domain consists of five cadherin-type repeats bound together by calcium ions, forming a parallel cadherin dimer EGF EGFR CCND1 CTNNB1 PMC5278183__F1 Regulation of Ciliogenesis by Inputs from the Cell Cycle AURKA KIF24 NEK2 MARK4 CEP97 PLK1 HDAC6 PMC5278183__F3 Relationships Between Cellular Proteostasis and Ciliogenesis AURKA RPGR GSK3B ATG14 RHEB TSC2 TSC1 OFD1 BBS4 IFT20 NDE1 ATG5 HDAC6 PMC6290922__F5 T-bet: a bridge between innate and adaptive immunity IFNG TH CXCR3 FOXO1 KLRG1 CCR7 CXCR5 CCR3 STAT4 MTOR BCL6 RUNX3 PMC5119679__F1 Hydrogen sulfide (H2S) regulating mesenchymal stem cell (MSC) function TRPV3 MSC RUNX2 TRPV6 CTNNB1 PMC5278183__F2 Regulatory Roles of the Cytoskeleton at the Base of the Cilia AURKA ABLIM3 LIMK2 BBS4 ARHA SRC PLK1 ABLIM1 HDAC6 PMC3584867__F9 The multiple functions of PE C6 C9 PLG PMC7577940__F1 Mechanosensation LATS1 SRC PMC4707207__F1 PI3K/Akt pathway RHEB TSC2 CDKN1B GSK3B PTEN PDK2 MTOR BCL2L11 IRS1 PMC3636885__F8 STAT3-mediated coincidence detection regulates a noncanonical pathway of IEG induction STAT3 EGF EGR1 GSK3A EGFR GSK3B PDK2 PMC3401455__F2 Rad51 filament formation and regulation RAD52 RAD51 PCNA PMC4985506__F7 The HGF/Met-FOXM1 positive feedback loop STAT3 FOXM1 HGF CCNB1 CCND1 PMC2927346__F1 Irinotecan pharmacogenomics UGT1A1 TDP1 UGT1A3 UGT1A9 CES2 CES1 NFKB1 ABCG2 BCHE ABCC2 ABCB1 PMC3401455__F1 Models for the repair of DNA double-strand breaks RAD52 RAD51 PMC5575202__F5 Significant association of the 97 gene signature with transcription factors TP53 and HIF1A HEL-S-101 RASSF2 THBS1 TIMP3 THBS2 DSC3 HIF1A KCNN4 FOS ACTA2 FGF7 SEMA3C INHBA IGF1 TMEPAI SCG2 PALLD PDGFRA IGFBP7 EGR2 PMC10055176__F8 Changes in Environmental Stress over COVID-19 Pandemic Likely Contributed to Failure to Replicate Adiposity Phenotype Associated with Krtcap3 TARDBP HMGCR MSMO1 FOXC1 SREBF2 AACS FDFT1 BCL2L11 MSX2 INSIG1 CP PMC3820561__F1 BRCA1 domain structure and subcellular transport pathways BARD1 BRCA1 PMC8114929__F3 Rhizopine signalling to control PGPR PGP SI ACD PMC3032036__F10 The paracellular pathway in vertebrates and insects CRB1 ESAM ASIP PATJ L1CAM CTNNB1 PMC8874090__F4 Long non‐coding RNAs in diabetic wound healing: Current research and clinical relevance MAX TET2 PROX1 PLOD1 HBEGF FBN1 EZH2 PTEN FAP IGF2 TDG PMC12024770__F1 STEAP1 protein structure, biological function, and possible carcinogenic regulatory pathway STAT3 FOXO1 NACA2 EIF4E PMC8582580__F3 New Look of EBV LMP1 Signaling Landscape LIMD1 TRADD RNF31 JAK3 TRAF5 IRAK1 IRF7 HIF1A IRF4 GBP1 TRAF2 CTNNB1 PMC5907526__F8 Overview of the TLR4 signalling pathway IRF3 TRAF6 IL1B PMC7503766__F7 Nodulation (NOD)-like receptor signaling pathway (PM vs INA TANK APP PMC7662673__F8 Suggested mechanism by which nonanal induces the growth factors expression in DPCs via the cAMP signaling pathway IGF1 LEF1 CTNNB1 PMC5176143__F3 Zrf1 controls the temporal expression of the genes related to cardiomyogenesis MESP1 WNT3A MYOCD NODAL TBX5 HAND2 ISL1 LEFTY1 DKK1 BMP4 CER1 HAND1 GATA4 PMC4997077__F1 Oxidative stress and mTORC1-mediated Treg cell differentiation AHR IL6 FOXP3 PMC3136221__F1 “big picture” between DM2 and cancer IGF1 IGF1R MTOR PMC6854381__F6 CMTM7 activates Rab5 which controls the fusion of early endosomes and affects EGFR protein trafficking, an essential part of the PI3K/AKT signaling pathway EGF CMTM7 EGFR PMC5487703__F1 Trypsin-dependent pathological pathway in chronic pancreatitis SPINK1 CTRC PRSS1 PMC9031703__F7 Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/Beta-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response GTF2F1 APC PTEN GRB2 MTOR IRS1 CTNNB1 PMC4516212__F5 Summary of the inhibitory effects of BSNXD on osteoclast differentiation.Notes: The suppression of BSNXD on RANKL-induced activation of the NFATc1 via ERA pathway is correlated with the inhibition of osteoclastogenesis SYK NFATC1 GRB2 TRAF6 PMC6281418__F7 Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood JUN WNT3A EGFR WNT7A WNT1 MYC AXIN2 PMC5415623__F7 Schematic pathway for low-dose PTX inhibition of cell growth in colorectal carcinoma cells GLS SLC7A11 PMC6146175__F5 STAT 3 signaling pathway and site of action of napabucasin MMP2 IL6 RHO PMC9031703__F6 Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/Beta-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response RHEB TSC2 TSC1 GSK3B PTEN GRB2 MTOR IRS1 PDE4A PMC9031703__F5 Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/Beta-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response RHEB TSC2 TSC1 GSK3B PTEN MTOR IRS1 PMC6444804__F2 Hypothalamic Lipids and the Regulation of Energy Homeostasis UCP2 CNTF FAS POMC AgRP PMC5326620__F1 Dual functions of IRF3 in antiviral defense BAX TBK1 IRF3 TRAF3 TRAF6 TRAF2 PMC6997700__F1 Leaf lipid pathways and hypotheses for acyl flux into TAG LPA FAS PC PMC6449224__F4 MicroRNAs regulate the smoking‐related ERBB2 signaling pathway EGF JUN BAD TGFA NRG3 MTOR SHE MYC NRG4 NRG2 CRK HBEGF CBL EREG PRKCA BTC PAK6 GRB2 CAMK2G PMC8958685__F6 Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies PCSK9 BAX CD36 TLR4 IL6 ABCA1 PMC7469327__F3 Action of the NLRP3 inflammasome PANX1 GSDMD NLRP3 TRPC1 MYD88 PMC2819006__F1 Key mechanisms involved in colorectal carcinogenesis MSH6 MSH2 COX2 APC CTNNB1 PMC5833072__F11 Schematic view of the potential mechanisms by which RNS60 protect motor neurons and ameliorate the neuromuscular impairment in ALS GFAP MBP FOXP3 PMC3331761__F4A Concordance of Changes in Metabolic Pathways Based on Plasma Metabolomics and Skeletal Muscle Transcriptomics in Type 1 Diabetes HRAS PTGIS CS GRB2 IRS1 PMC3282989__F2 Recapitulation of heart development can provide useful insight for optimizing differentiation protocols NODAL ATF2 GATA4 PMC7439102__F4 Signaling pathway diagram GML ATR PCNA PML ATM PTEN PMC6879940__F1 Proposed mechanisms of podocyte susceptibility to lipid-mediated injury TG NLRP3 CD36 SOAT1 ABCA1 PMC2553712__F1 Design, Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domains in XIAP TNF APAF1 FADD PMC4271318__F8 FGF signaling specifies hematopoietic stem cells through its regulation of somitic Notch signaling WNT16 FGFR4 DLD PMC4469999__F2 Complement cascades C2 PMC11634591__F1 CGAS-STING signaling pathway CGAS IRF3 IRF7 PMC4878431__F2 Schema of IR structure and insulin signaling pathways in vascular cells VCAM1 GRB2 INS PMC7400212__F1 In (A): Interactions of methionine cycle, folate cycle, transsulfuration and methylation pathway VIT FPGS PMC10138709__F3 Canonical and non-canonical Wnt signalling APC ATF2 RHO PMC11634591__F4 cGAS-STING pathway in the liver plays a key role in mediating NAFLD/NASH/ALD TBK1 CGAS TLR4 IRF3 PMC11634591__F3 cGAS-STING pathway plays a critical role in mediating obesity in adipose tissue TBK1 PDE3B CGAS TLR4 IRF3 PMC10138709__F5 Hippo pathway and its crosstalk with other signalling pathways LATS1 OGT LATS2 AMOT APC RHO NF2 NLK AREG VGLL4 CTNNB1 PMC11634591__F2 cGAS-STING pathway plays a significant role in mediating cardiovascular disease LATS1 TBK1 ALDH2 LATS2 CGAS GSDMD IRF3 TREX1 YAP1 PMC8103724__F1 Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion MLST8 ATG3 ATG12 ULK1 SNAP29 ATG14 MTOR STX17 VAMP8 ULK2 PMC7395311__F3 Cytokine and receptor Janus kinase pathway IL19 CNTF TSLP IL24 OSM LIF JAK3 CLC EPO TPO JAK1 TYK2 PMC3898671__F2 Synthesis of the C5 isoprenoid precursors IPP and DMAPP IPP MVD IDI1 PMC11187367__F6 Summary of the findings CD44 GDF10 CXCL12 GRP CYTL1 CD74 IL18 MIF IL8RB CD163 PROC TNF PMC10138709__F2 Hedgehog signalling pathway SUFU PTCH1 SOX2 SHH SMO MYC PMC3530456__F5 Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis LINGO2 PLCB4 PLSCR1 TXNIP KCNJ12 SLC26A4 LILRB3 BCAS1 RAET1E MPPED2 TREM2 CTNND2 FRAT1 CLEC4A FGFR1 PFKM CEBPB CCR1 MSX2 NRN1 NNAT IKZF1 AXL DMBT1 TYRP1 GJB2 FURIN RUNX3 PEG10 PLXDC2 LILRB4 FBP1 GPNMB KCNC4 PSAP TNFSF10 IGSF6 FGF18 PMC3520539__F1 Generalized overview of the regulation of apoptosis by sphingolipids CASP9 BAD PMC7280066__F1 Regulatory functions of oncogenic and tumor suppressor long non-coding RNAs (lncRNAs) in the Wnt/Beta-catenin signaling pathway attributed to the pathogenesis of non-small cell lung cancer (NSCLC) SOX9 DKK1 APC SOX2 SOX4 CTNNB1 PMC9503946__F10 Coronaviral Inhibitors of the Nucleocapsid Protein Identified In Silico and In Vitro from a Large Natural Product Library MAVS TRIM25 RIPK1 CXCL8 CP PMC4300866__F2 Three pathways of complement activation: classical, lectin, and alternative pathways MASP1 C6 C7 MASP2 HEL-S-62p C2 C1S C4A C4B_2 PMC8603497__F4 Transcriptome and metabolome analysis to reveal major genes of saikosaponin biosynthesis in Bupleurum chinense IPP MVD MVK PMC3041769__F4 Antibodies against CD20 or B-Cell Receptor Induce Similar Transcription Patterns in Human Lymphoma Cell Lines SRGN DAPP1 DDB2 VASP SCARB1 BCL2A1 HMMR BCL2 CREM RTKN PMC4300866__F1 Biological functions of the complement system BCR HEL-S-62p C9 CR2 C4B_2 CR1 PMC8957965__F8 Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control TFAM PINK1 CYP2E1 PMC8842603__F1 Tankyrase Inhibitor for Cardiac Tissue Regeneration: an In-silico Approach TNKS APC LRP5 LRP6 CTNNB1 PMC9319717__F2 Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis SOCS1 APC SOCS5 IL4 SOCS3 IL31 PMC8671096__F2 Construction of synthetic microbial consortia for 2-keto-L-gulonic acid biosynthesis GOT2 PDX1 ARG1 PFKL MDH2 PMC5678971__F1 ULK/Atg1 redirects machinery used under vegetative conditions for stress-induced autophagy ATG101 SEC16A ULK2 PMC7525161__F7 Identified key pathways ND1 CAD LIF HP PMC8416724__F3 CD47/SIRPA pathway mediates cancer immune escape and immunotherapy CGAS SIRPA IRF3 CD47 PMC9534575__F2 Quaternary ammonium compounds in hypersensitivity reactions TH TSLP IL4 PMC2686461__F1 BCR signaling pathway BCR CSK PAG1 CD22 LYN PMC8416724__F2 CD47/SIRPA pathway mediates cancer immune escape and immunotherapy HEL-S-92n SIRPA TCF4 QPCTL MYC CD47 SET CTNNB1 PMC8103321__F1 APC Promoter Methylation in Gastrointestinal Cancer CDX2 USF2 APC USF1 GSK3B CEBPZ EZH2 YY1 ARC CTNNB1 PMC12025301__F1 Ferroptosis signaling pathway FTL STEAP3 GPX4 LPCAT3 FACL4 ALOX15 HEL-S-64p CP PMC3178610__F5 Determining Signalling Nodes for Apoptosis by a Genetic High-Throughput Screen GNAS CCL13 EGR1 SLC37A4 NFKBIA ATP1A1 TNF PMC4536022__F2 Integrative Analysis of MicroRNA and mRNA Data Reveals an Orchestrated Function of MicroRNAs in Skeletal Myocyte Differentiation in Response to TNFA or IGF1 CDC2 CDC6 MYBL2 CDT1 CCNA2 PLK1 MKI67 ELF4 CDK6 TRIM28 CDKN1A CCND2 WEE1 CHEK1 SLBP CCNB1 CREB1 CCND1 PMC6302218__F2 Autophagy and the inflammasome NLRP3 IL16 IL1B PMC5264637__F1 Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom GLA ADA PMC9637147__F1 Molecular mechanisms of ferroptosis SLC11A2 SLC3A2 GPX4 LPCAT3 SLC46A1 SLC7A11 SLC48A1 ABCA1 DHODH POR HMOX1 TFRC HMGCR OGDH FLVCR2 DPP4 ADFP GLS2 HEL-75 PMC9105255__F6 Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Schizophrenia SI IMPACT PMC6977534__F2 Roles of zinc transporters in B cells of different stages SLC39A10 BCR LYN PMC515251__F1 A minimal metabolism PTS HEL-S-5 PMC4399033__F1 Pyrimidine synthesis and salvage pathways in Toxoplasma gondii UPRT OMP DHODH PMC3198893__F5 One of the networks of genes strongly induced in dendritic cells but less so, unchanged, or suppressed in macrophages PPM1J EWSR1 NR2A1 RNF4 MC2R PPP1R10 FSHR TRAF2 PMC3198893__F4 One of the networks of genes commonly induced in both dendritic cells and macrophages when infected by bacteria, in both human and mouse KLF6 PLSCR1 MARCKS ABCC3 PMC3811010__F3 Target genes of CDX1 and CDX2, and the BMP/TGFB signaling pathway GABARAP NTS SMAD1 TGFBI CCK DTX1 LYPLA1 GUCY2C NEUROG3 SPDEF SOX10 NR0B2 BAMBI ZNF483 CDX2 GPA33 ZNF382 S100G E2F3 HEPH POMC SI HEL-S-11 NBL1 NR1i1 BMPR2 MMP7 ALPI CDH17 LAMC2 JUNB ATOH1 APC UGT1A10 SLC2A2 UGT1A8 FURIN CLDN2 ENG HBEGF BMP1 CCL25 UGDH ACAT2 HOXA9 APOB DLX2 AKAP12 ACTG2 KLF4 RGS12 TGFB1 ITGB4 PCNA FABP1 LYZ NODAL RUNX2 INS TGFBR1 NR2F6 CCND2 HLA-G DHRS9 CLU FST TLX2 ACVRL1 NOTCH3 CCND1 RETNLB TEX2 JUN G6PC2 PYY NEUROD1 BMP7 CDX1 TFF3 ID1 AGR2 IL2RB TWSG1 HOXA10 MUC2 CAPN9 SCT PMC8416724__F4 CD47/SIRPA pathway mediates cancer immune escape and immunotherapy HEL-S-92n SIRPA CD47 PMC6714138__F8 Schematic diagram showing the cardioprotective effects of YWPC on DOX‐induced cardiotoxicity TGFB1 KEAP1 GCLM NQO1 BCL2 PMC4338835__F3 The catecholamine system in health and disease —Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes— TH SPR PNMT DBH PMC6160678__F6 An comprehesive metabolomics and transcriptomics study to identify metabolic pathway alterations in CFG treatment of ovarian tumor-bearing mice in vivo B4GALT1 LYZG SCD ACADS ACADL PMC7469327__F6 Drugs targeting inflammasome signaling in MS and EAE STAT3 NLRP1 STAT1 NLRP3 IL1B PMC9165361__F1 Implication of 14-3-3ζ-BDNF pathway in long-lasting memory enhancement and the rescue from memory deficits RGS14 BDNF PMC6364417__F7 Pathways affected by the combined selected kinase inhibitors in BRAF mutant melanoma cells tmp_locus_29 WEE1 CDK4 PMC3528378__F3 Mechanism of muscle protein synthesis inhibition by GCs IGF1 MTOR EIF4E PMC9455514__F4 Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer LTBP2 BMI1 CD44 OGT CCND2 PCGF1 PTEN ZEB2 ARHA CCNB1 CCND1 PCGF6 PMC5531360__F3 Possible interactions between signaling molecules VWF EPO ARHA FGF2 PMC7388835__F6 Gene interaction network map MRPS16 TNKS2 MERP1 FAM136A SERTAD2 PRPF40A RHO RERE ENY2 MAPK3 RBFOX2 ERF ACTR3 DUS2 LEPROTL1 MYRF TCEAL9 RAZ1 HNRNPUL1 NF2 DNPEP PMC7388835__F5 Network diagram representing the regulatory effects with top consistency scores STAT1 RIPK2 CHUK IKBKG PMC4076091__F7 GW1516 intervention inhibits progression of hepatic steatosis in mice FASN PCK1 CPT1A INSIG1 PMC6548416__F2 Impact of diet-derived signaling molecules on human cognition HRAS EGF JUN BAD RAF1 PRRT2 MAP2K1 MTOR PMC8537973__F9 Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations PIK3R2 PIK3R1 RPL38 MAPK3 RPL39 ACTA2 PIK3C2B EIF3S3 RPL17 PPP1R15A PDPK1 RPL28 AAG1 ATF4 EIF4A1 TRIB3 CCND1 EIF2AK2 EIF2B3 AGO1 RPL11 RPS5 HEL-S-89n RPL13 RPL6 EIF4E HRAS RPL3 RPS26 RPS27L EIF3C RPS4Y1 DDIT3 RPL9 RPL26 PS1TP5BP1 PMC7071696__F7 Mechanism graph of the regulatory network of miR-495/HOXC6/TGFB in the progression of OSCC SMAD4 HOXC6 TGFBR1 PMC6082538__F6 Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms C6 PES1 ECE1 SIT1 GPD1 GDA PMC6082538__F4 Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms ALPI HEL60 MAPDA GAL PMC6972508__F2 Mode of action of thalidomide and its derivatives in regulating host inflammatory response IL2 IL1B IKZF3 PMC4629506__F1 TLR and NFKB signaling disrupted by PID TBK1 TAB3 IRAK1 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC4046566__F2 Application of the algorithm to identify TNBC-associated genes NPAS2 NASP RCC1 HEL113 CCL18 BNIPL GABBR2 CENPE ROBO1 PLK1 FANCA KIF1A MED1 GATA3 MED24 RARA HMGA1 NOS1AP RARB SIX3 ERBB2 BCL2 SH3GL3 CIT PMC7803563__F1 Schematic model showing that the DEGs in the older melanoma patients by recurrence status converge at the Wnt signaling pathway PTGS2 FOS IL1B CTNNB1 PMC11999469__F8 Connection of Nrf2, NFKB, NLRP3 Pathways and the mechanism of SA RBX1 KEAP1 GCLM TLR4 NQO1 PMC8327141__F4 The MCTS1 and DENR Proteins in Regulating the Mechanisms Associated with Malignant Cell Transformation PTEN ARHA SRC MCTS1 PMC7368990__F6 Schematics of glycolysis, tricarboxylic acid cycle, and pentose phosphate pathway showing changes at the translational level of enzymes involved in the different steps ACLY HEL107 FH GLS TIGAR CS RPE HEL-S-304 RPIA FBP2 OGDH F2 HEL-S-162eP FBP1 PMC7272692__F4 Mitotic/endocycle switch CDC2 MYB WEE1 TTK CDK2 DAP MYT1 PMC4354340__F8 miR-4689 regulates EGFR signaling pathway EGFR KRAS PMC9437264__F12 CGMP/Akt/GSK-3B signaling pathway on atrial natriuretic peptide secretion in rabbits with rapid atrial pacing PGC VASP GSK3B PMC10648128__F5 DEGs belonging to the gap junction signaling pathway in the hippocampus (magenta) and frontal cortex (red) of OXYS rats at PND3 and PND10 CA3 LAT PIR PMC3508723__F8 Model of Tat/Beta-catenin interaction in astrocytes IFNG AXIN2 CTNNB1 PMC5259746__F3 Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway TH BAX BAD FAS AIP IGF1R ARHA TNF EDC3 IGF1 BCL2 SRPK2 GRB2 TRAF2 PMC3574110__F4 Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr−/− Mice ATF3 GPC1 BDH1 THBS2 BMP2 CTH AIP ADFP ADAMTS2 BHLHB2 CP PMC10940631__F3 Compensatory relationship between the ubiquitin‒proteasome pathway and the autolysosome pathway CDKN1A ULK1 CCND1 PMC3356354__F8 High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes RP1 CD40 MAP3K7IP1 TIRAP TLR4 CD14 MTOR TNF LBP MYD88 PMC3926670__F4 Enriched pathway of the target gene union of radiation-response miRNAs NKX3-1 BAD CDK2 BCL2 PTEN MTOR PMC3356354__F9 High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes SYK BTK BCL10 CD22 BLNK CD19 LYN GRB2 PMC5643010__F2 Janus kinase antagonists and other novel small molecules for the treatment of Crohn’s disease SMAD2 SMAD4 PMC4152115__F5 Plausible molecular mechanism of migration and osteogenic differentiation of BMSCs by Ce through Smad1/5/8 signaling pathway BMPR2 SMAD1 DKFZp781O1323 BMP2 RUNX2 PMC12152576__F2 Contribution of type-I IFN-mediated neuroinflammation to Parkinson's disease progression STAT1 CGAS STAT2 IFNAR2 IRF9 IFNAR1 IRF3 IRF7 JAK1 TYK2 PMC10216802__F2 LPS (TLR4)-mediated inflammation and its interplay with RhoA activation and the downstream ROCK signaling pathways ROCK2 TLR4 ROCK1 ARHA TNF PMC6545862__F1 A potential nuclear factorKB activation pathway obtained by RNA-sequencing analysis in canine diffuse large B-cell lymphomas CSA2 SYK CD79A TNFAIP3 CARD11 TLR9 BLNK CD19 MTOR TRAF6 IKBKG MYD88 BLK BTK BCL10 PLCG2 RELA NFKBIA LYN SRC PMC4163606__F1 LIF signaling and post-translational modifications of some stemness transcription factors STAT3 SUMO1 LIF SOX2 KLF5 SOCS3 PMC2536868__F7 Pathways for major lipid metabolism ACLY FAS CRAT DGAT1 AGPAT3 SQLE AACS FADS2 FADS1 GPAM PMVK PC FDPS PMC9355246__F2 Regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling RHEB MLST8 SGK1 ULK1 PTEN MTOR DEPTOR EIF4E PMC5652964__F6 Proposed working model of ZZR on the Hedgehog signaling pathway-mediated MDR in colorectal cancer cells SUFU PTCH1 SMO GLI3 PMC6562634__F3 Schematic model of regulation of the Hippo pathway by numerous signaling pathways in cancer LATS1 MUSK LRP4 LATS2 PAK1 HEL-S-28 NF2 PMC6562634__F2 The Hippo pathway drives fibrosis across the organs LATS1 LATS2 NF2 PMC6562634__F1 The Hippo pathway in the pathogenesis of tissue fibrosis LATS1 ACTA2 SNAI2 LATS2 INHBA SMAD2 IHH FJX1 TTF1 PMC11245093__F4 Genomics-based reconstruction of pathways involved in the utilization of monosaccharide derivatives RPE NAGA FRK MIP PMC5025072__F5 Network-Based Data Integration Approach to Support Drug Repurposing and Multi-Target Therapies in Triple Negative Breast Cancer IL15 PIK3CA LEP AKT3 MYC IFNG STAT1 SOST CBLC SPRY1 PIM1 SPRY4 IRF9 SPRED3 PTPN11 PTPN6 PIAS2 SPRY2 SOCS7 CBL SPRED1 SOS2 CREBBP EP300 JAK1 GRB2 THPO CISH STAM2 PMC6695454__F3 Therapies targeting p53 functions BAX MDM2 PRIMA1 PMC3504715__F8 Cytokine-induced CITED2/MYC/E2F3/p21CIP1signaling in lung cancer HDAC1 CITED2 TGFA SP1 E2F3 EGFR MYC TGFBR1 PMC6562634__F4 YAP/TAZ-mediated regulatory networks in cancer CDC2 SNAI2 HEL113 THBS1 FSTL1 AXL SOX2 TBX5 SKP2 FGFR2 FOXM1 SLIT2 SOX9 DKK1 FGFR4 FGFR1 COIL CCND1 PMC8465517__F2 Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease TF CREB3 ARF4 ATF4 EIF2A PMC3844829__F3 Metacore™ apoptosis signaling pathway relating to mitochondrial proteins BAX BAD FAS IGF1 TNF HRK PMC3844829__F2 Metacore™ apoptosis signaling pathway relating to TNF receptors, NFkB and BCL-2 antiapoptotic family genes TNFRSF18 TNFRSF21 TNFRSF10A FADD PMC1323499__F1 New Approaches to Vaccine Adjuvants: Inhibiting the Inhibitor TLR3 TLR4 IRF3 TLR7 MYD88 PMC8465517__F4 Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease SP1 ATF4 EIF2A PMC3844829__F4 Metacore™ apoptosis signaling pathway relating to caspase activation CAD IGF1 RS1 PMC5908886__F3 Peroxisome proliferator-activated receptor gamma (PPARG) activation BAX BAD COX2 PTEN TNF CTNNB1 PMC5908886__F4 Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/Beta-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis APC LRP5 LRP6 CTNNB1 PMC9324774__F1 Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway RBX1 KEAP1 GSK3B PMC6003829__F8 R-loops cause genomic instability in Wiskott-Aldrich syndrome Thelper lymphocytes TH ATM CDK9 PMC11879902__F4 Diagram of glycolytic signaling pathway in senescent cells HEL-S-133P HK2 TIGAR MDM2 MYC IRS1 PMC11879902__F3 Aerobic glycolysis in tumor cells FOXC2 HEL-S-133P HK2 TIGAR PMC12246557__F5 Type I, type II, and type III interferon signaling and IFN‐I pathway‐related inhibitors STAT1 STAT2 IRF9 JAK1 TYK2 PMC5826217__F1 Insulin/IGF-1/PI3K/Akt/GSK3B/tau signaling IGF1 GSK3B IGF1R IRS1 PMC9275048__F2 Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis PLCD3 DVL1 PIK3CA SV2B PIK3R2 SMAD2 PIK3R1 MAPK9 SOCS3 IL6R LAMB1 VEGFB SOST PLCG2 OSMR PDGFC FGFR1 NRAS FLT1 AKT1S1 CYP27A1 LPL IFNGR1 LRP6 NTRK2 DVL2 IL10RA ITGB3 FZD4 SOS2 PLCB2 THBS4 GNA13 IL10RB PIK3R5 CD36 AKT3 IL2RG SHC2 IL11RA TGFBR1 TGFBR2 PLCG1 COL1A1 PPP2R3B NOTCH3 RXRB VWF ACTG1 THBS1 TLN2 ARHA KRAS RAC1 KITLG SFRP1 SPP1 FGF7 ITGA1 IKBKB ERBB2 LYN CPT1A PS1TP5BP1 LTBP1 PPARG SYK CSF1 ACSL3 SHC1 PIK3CD IL3RA FACL4 PTPRF EFNA1 WNT5B SLC27A1 PHLPP1 COL4A2 COL4A1 SRC SCD CRKL VEGFA NOTCH2 PCK2 HRAS CRK ACSL1 SFRP4 COL6A1 IFNAR2 IFNAR1 RXRA LAMB2 GRB2 SIRT1 LAMA3 CDC42 TNC FERMT3 COMP ITGB4 EGFR THBS2 THBS3 CHAD MTOR ITGAV IKBKG CSF3R IFNGR2 CSF2RB INSR IL13RA1 CHUK TLN1 CACNB3 PLCB3 CACNB1 RPTOR PDGFD COL1A2 ITGA7 NR1H3 ADIPOR1 ADIPOR2 NGFR SMAD6 PTPN1 FABP4 FGF2 CD44 PLCE1 XB ITGB1 DVL3 SLC27A4 PF4 PMC5922346__F6 Tumor cell death after electrotransfer of plasmid DNA is associated with cytosolic DNA sensor upregulation TBK1 MLKL IRF3 TYK2 PMC8763513__F10 3B,23-Dihydroxy-12-ene-28-ursolic Acid Isolated from Cyclocarya paliurus Alleviates NLRP3 Inflammasome-Mediated Gout via PI3K-AKT-mTOR-Dependent Autophagy NLRP3 TXNIP IL16 MTOR PMC12246557__F3 Nucleic acid sensors and downstream signaling pathways induce type I IFN production STAT2 IRF9 IRAK1 IRF7 TRAF3 TRAF6 IRAK4 MYD88 STAT1 PDC TLR8 TLR7 TYK2 PMC3471537__F1 HER2 activation EGFR PTEN GRB2 PMC11996656__F3 Signaling pathways involved in the pathophysiological development of OA, along with their corresponding targeted therapeutic drugs USP25 OGT HMGB1 METRNL TXNIP SMAD2 IRF1 CMPK2 MTOR TRAF6 MYD88 GBP5 STAT1 GSDMD NLRP3 TLR4 PMC11996656__F2 Pyroptosis in OA pathogenesis HMGB1 GSDMD NLRP3 PMC11996656__F1 Classical, non-classical, and other pathways involved in pyroptosis GSDMD NLRP3 DFNA5 IL1B PMC2180420__F9 Co-coculture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells FYN EGFR GRB2 PMC6026536__F1 Reactions and enzymes of proline metabolism in higher organisms PRODH PYCR2 PMC3087811__F8 Schematic model for the role of TGFB signaling pathways in iTreg and Th17 cell development TGFBR3 FOXP3 PMC4702573__F6 Simplified model for CCC DNA synthesis and innate immune induction by HBV in AML12HBV10 cells TBK1 CGAS IRF3 PMC2943859__F9 TNF-R1 signaling pathways TRADD GADD45B TRAF1 TRAF2 FADD PMC8778078__F3 Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging NLRP3 IL18 IL1B PMC2949723__F3 Eicosanoid signaling pathway from Ingenuity Pathway Analysis software ALOX5 ALOX15 ALOX5AP PMC8755999__F1 Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management POR HSD3B2 CYP21A2 SRD5A2 FDXR STAR CYP17A1 CYP11B2 CYP11A1 FDX1 PMC5350732__F3 Gene transcripts associated with sensitivity to gefitinib and EGFR and/or head and neck cancer, identified from the genome‐wide statistical analysis, followed by pathway analysis HEL-S-22 HEL113 LY6D TGFA CCNL1 RASSF1 EGFR CD82 CTNND1 KRT16 SMAD4 TGFBR1 SERPINB3 NR1B3 FYN ARNT2 CSTA EFNB2 FBN1 TIMP3 LAMC2 AREG S100A2 PTPN6 SCCA2 FGF2 GRB7 ELF1 RELA ADRB2 KRT13 ELF3 PMC9084610__F1 COVID-19 Infection During Pregnancy Induces Differential Gene Expression in Human Cord Blood Cells From Term Neonates FOXO1 CRTC2 ADAM10 PMC4133771__F1 Possible signaling of G DCC SEMA3A GSK3A GSK3B BDNF CTNNB1 PMC6378068__F5 GPL pathway constructed in this study EGF RAN BAD TRADD COX2 EGFR RXRA ERBB2 PMC4768116__F2 Activation of nuclear factorKB: Canonical and non-canonical pathways CD40 BCL10 BCR TLR4 RELA RELB PMC8517843__F3 ADAMs family in kidney physiology and pathology EGFR CXCL16 ACE2 NOX4 PMC5665066__F1 PolyI:C induces tumor necroptosis via the TLR3 -TICAM1 pathway TBK1 MAVS TLR3 MLKL TICAM1 IRF3 PMC4745409__F2 Pathways involved in internalization and sensing of dsDNA TBK1 HMGB1 MAVS BCR IL16 TLR9 AIM2 IRF3 IRF7 TRAF3 TRAF6 MYD88 PMC6760864__F3 New insights into cytoskeletal remodeling during platelet production CDC42 PACSIN2 ARHA HEL-S-52 PMC2480606__F2 NFKB pathway in skeletal muscles BAX YY1 CCND1 PMC11807217__F8 Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis TF BAX CDK6 HEL-S-28 NR1C2 CDK4 PMC9024148__F6 Multi-Omics Characterizes the Effects and Mechanisms of CD1d in Nonalcoholic Fatty Liver Disease Development AMY1A CYP1A2 HEL-S-22 APOA4 ADM GSTM3 FADS2 PDE4D PMC2816026__F7 Met signal transduction exploited by InlB from L CBL FYN NEK9 PMC8112564__F6 ANKRD22 enhances breast cancer cell malignancy by activating the Wnt/Beta-catenin pathway via modulating NuSAP1 expression NUSAP1 ANKRD22 CTNNB1 PMC2480606__F1 An outline of major signaling pathways leading to NFKB activation MAP3K7IP1 LTBR TRADD BCL10 RELB ATM TRAF6 TRAF2 MYD88 PMC8607246__F2 A novel potentially transforming somatic mutation in CSF2RB gene in breast cancer STAT3 CSF2RA CSF2RB IL3 MTOR PMC8287856__F1 Dissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution MMP7 THY1 SMAD2 SHH MTOR CTNNB1 PMC5003773__F1 Empowering Regulatory T Cells in Autoimmunity FOXO1 PTEN FOXP3 RBPJ PMC3035137__F2 Effects of Hfe deficiency and the associated low hepcidin and intracellular iron levels on macrophage TLR4 signaling TLR3 TLR4 MAL HFE MYD88 PMC8777499__F1 Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer MTHFD2 MTHFD1 PHGDH SHMT1 MTHFD2L PSAT1 HEL-S-51e PSPH PMC7767764__F1 Lipofuscin and drusen in the RPE RPE ATR RDH8 PMC9050318__F6 Mechanism of Osthole in the Treatment of Gastric Cancer Based on Network Pharmacology and Molecular Docking Technology BCL2L1 TRAPPC3 TNF PMC8870390__F1 Precision Targets for Intercepting the Lethal Progression of Prostate Cancer: Potential Avenues for Personalized Therapy STAT3 PTEN JAK1 IL6R PMC6086630__F7 Network mappings were Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of HOXA3 co-expression genes in NSCLC NKX3-1 PRKD2 MYLK PDGFD INHBA EGFR AKT3 EVI1 PPARGC1A CDKN2B DCN GLI3 PMC3903560__F7 Ingenuity pathways analysis HAVCR2 MAP3K1 CARD16 APOL1 CD84 NFE2L3 IL18BP APOL3 PMC8903057__F4 Diverging effects of LMW-HA and HMW-HA in neurodegeneration and AD CD44 TLR4 HAS1 PMC7934812__F1 Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation TIRAP TLR4 IRF3 TRAF3 TRAF6 MYD88 PMC3613823__F8 The proposed therapeutic mechanism of caspase-7 ablation in ADRP T17M RHO retinas F8 HIF1A ATF4 RHO MTOR PMC4839461__F1 Schematic overview of de novo and salvage dNTP biosynthetic pathways and the mechanism of action of dCK-dependent nucleoside analog prodrugs PNP ADA PMC3193407__F1 NFKB activation by the canonical pathway LPA EGF EGFR PMC7934812__F2 Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation TIRAP TLR4 IRF3 TRAF6 IL1B MYD88 PMC12116171__F3 Up-regulated circadian rhythm pathway and phenological effects of cul4 mutant PRR9 PRR7 ELF3 CAT56 PMC5805723__F7 Oncogenic cooperation of BRAF V600E and TERT promoter mutations TERT MYC FOS PMC10372325__F6 Transcriptomic and physiological analyses reveal temporal changes contributing to the delayed healing response to arterial injury in diabetic rats JUND BATF JUNB PML SP2 IRF1 TCF4 BHLHB2 CTNNB1 CEBPA UBTF NFE2L2 EP300 FOXP3 GATA4 CEBPB NOTCH1 PMC8879755__F2 Innate Immunity in Mucopolysaccharide Diseases GFAP NLRP3 TLR4 TNF IL1B PMC10217168__F14 Graphical summary of the protective effect of Lactiplantibacillus plantarum Lac16 against enterohemorrhagic E TH BAX TLR4 FZD7 TRAF6 CCND1 AXIN2 CTNNB1 MYD88 PMC5487892__F3 DNA substrates and protein factors required for S-phase checkpoint activation MRC1 ETAA1 DNA2 PCNA CDC45 RAD17 POLE PMC5645256__F2 Association between expression of cell cycle proteins in NETs according to pathway CDKN2A CDK6 CCNE1 CDKN1A CDKN1B CDK2 CCND1 CDK4 PMC8509327__SF3 Non-Canonical Wnt Signalling Pathways in Bone Biology ROR2 LRP5 LRP6 ATF2 ARHA NLK MTOR TRAF6 CTNNB1 PMC5443707__F1 Coordination of DNA Single Strand Break Repair OGG1 LIG1 FEN1 PCNA PARP1 PMC4800996__F2 Serine biosynthesis and utilization GLDC PHGDH SHMT1 PSAT1 HEL-S-51e PSPH PMC8509327__SF2 Non-Canonical Wnt Signalling Pathways in Bone Biology CDC42 ROR2 ARHA RAC1 PMC8509327__SF1 Non-Canonical Wnt Signalling Pathways in Bone Biology BCL9 APC ROR2 LRP5 LRP6 CTNNB1 PMC3913524__F1 The PI3K/Akt/mTOR pathway substrates and associated cellular functions RHEB TSC2 RICTOR PTEN MTOR EIF4E PMC3607121__F1 Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer HSD17B3 UGT2B15 HSD17B6 HSD3B1 HSD17B2 AKR1C2 AKR1C1 CYP7B1 PMC10525295__F1 Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia FH HEL-S-62p SCD PMC3890879__F8 Model of mevalonate and Hippo pathways regulating YAP-controlled RHAMM transcription and cancer cell motility LATS1 LATS2 ARHA PMC8122612__F4 Salivary Proteome Changes in Response to Acute Psychological Stress Due to an Oral Exam Simulation in University Students: Effect of an Olfactory Stimulus F13B JCHAIN GKN1 ALB HEL-S-47e MBL2 FABP5 ZNF491 PLEKHG6 HBM NPB MUC7 AMY2B PMC8734249__F2 CD70-CD27 axis in oncology: the new kids on the block CD44 HEL113 CD27 TNLG8A SOX2 PMC8734249__F1 CD70-CD27 axis in oncology: the new kids on the block CD27 TNLG8A TRAF2 PMC7691336__F9 Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling RYR2 NFATC4 GATA4 PMC3461086__F3 Canonical Wnt signaling pathway APC GSK3B LRP5 LRP6 CTNNB1 PMC11755046__F9 Synergy between the LINC01419/miR-8070/RAD51AP1 axis and HBV in HBV-associated HCC RAD51AP1 PMC8628653__F1 Disruption of the Diurnal Cortisol Hormone Pattern by Pesticide Use in a Longitudinal Study of Farmers in Thailand CYP21A2 STAR CYP17A1 CYP11B2 CYP11A1 PMC3461086__F4 Simplified diagram of signal pathway convergence at downstream nuclear targets SOX9 SMAD4 RUNX2 PMC7327974__F3 A) A model depicting the regulation of apoptosis through the TNF pathway and B) Simulation of the signaling process BAX EGF BAD EGFR CYCS KDR MTOR VEGFA TNF PMC3016890__F1 The p38MAPKsignalling pathway CDC42 MAX CCND3 STAT1 MX2 ATF2 CCND1 MEF2C PMC6535827__F3 Neuroprotective effects of resveratrol in AD BAX COX2 GPX1 PMC8935233__F8 PROX1 promotes breast cancer invasion and metastasis through WNT/Beta-catenin pathway via interacting with hnRNPK PROX1 APC GSK3B WAS ZNRF3 HNRNPK CTNNB1 PMC6708252__F1 Interactions between VHL, HIF and the NFKB signaling pathway EGF TNF VHL PMC5458139__F5 Mutational Signatures in Breast Cancer: The Problem at the DNA Level UNG PMC5912715__F3 Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation LTA GYPE PTGIS LTC4S PTGS1 PIGS PTGS2 PMC7186480__F7 Possible cross-talk of IFNs and the AIM2 inflammasome pathways in AMs from TB patients (AMTB) modulated by M IFNG STAT1 STAT2 TLR4 CD14 IFIT3 AIM2 IRF1 TAP1 TRAF6 MYD88 PMC7363763__F2 Endothelial cilium regulates various signaling pathways involved in the vascular barrier, such as HH and Notch pathways EVC GPR161 SUFU DLL4 PTCH1 SHH SMO NOTCH1 PMC4463188__F7 MEL-18 loss mediates estrogen receptor–A downregulation and hormone independence SP1 SENP1 PRC1 PMC1766317__F5 Model: A similar CARMA-Bcl10-MALT1 signaling pathway mediates NFKB activation in response to antigen receptor stimulation in lymphocytes and AT1R stimulation in liver cells BCL10 IL1B PMC5655777__F2 This schematic diagram depicts the signaling pathways that possibly drive BAVM pathology SMAD2 SMAD4 PMC4333762__F3 PRb/E2F pathway regulates cell cycle progression E2F2 E2F4 E2F3 E2F6 CDK2 E2F7 E2F5 CDK4 PMC6649605__F8 Proposed mechanism by which gremlin regulates EMT and ECM protein expression in LECs SMAD1 DKFZp781O1323 SMAD2 SMAD4 PMC3589762__F2 Pathways regulating intestinal sterol absorption and homeostasis ABCG5 MTTP CD36 ACAT2 NPC1L1 ABCA1 PMC6284860__F1 p53 limits B cell receptor (BCR) signalling: a new role for miR-34a and FOXP1 SYK MYB BTK BCR PLCG2 CD22 BLNK CD19 PTEN LYN MYC PMC6511523__F4 Molecular biological features in the adrenal gland of Hatano rats PRL MC2R PMC2846156__F3 Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer TBK1 BTK TLR4 MAL IRF3 IRF7 TRAF3 TRAF6 FADD PMC9058298__F6 Heterogeneous nuclear ribonucleoprotein K promotes the progression of lung cancer by inhibiting the p53‐dependent signaling pathway ATR ATM HNRNPK CCND1 PMC8745478__F2 P38 MAPK Components and Modulators as Biomarkers and Molecular Targets in Cancer BAX GATA2 ATF2 CDC25B PMC3989185__F8 Stiffness-Activated GEF-H1 Expression Exacerbates LPS-Induced Lung Inflammation LOX RHO PMC8368762__F1 Pyroptosis in cardiovascular pathologies: Role of noncoding RNAs RIPK3 FAS TRADD NLRP3 GPX4 MLKL IL33 IL18 RIPK1 MTOR TNF FADD PMC9653341__F3 Immune response associated with ischemia and reperfusion injury during organ transplantation CCL22 NOTCH1 CCL17 PMC5713646__F1 Chemical synthesis of n-butyraldehyde from petrochemical feedstock HBD PMC5126119__F2 TLR-4/LPS signaling pathway activated by LPS in ALD EGR1 CD14 IRAK1 IRF3 TRAF6 LBP IRAK4 MYD88 PMC4146087__F5 Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder BDNF SST PMC4146087__F1 Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder GRB2 SHE BDNF PMC4146087__F2 Interaction of drug and signaling pathway in relevance to depression.Sex steroid hormones serve as an example BDNF PMC11004986__F8 Autotaxin and lysophosphatidic acid deficiencies on depression-like behaviors in mice exposed to chronic unpredictable mild stress LPA SYP BDNF PMC6131826__F6 Phosphatidylinositol signaling pathway TK1 PI3 PTEN PMC2737000__F4 TNF-induced NFKB and apoptosis pathways FAS TRADD TNFRSF10B MCL1 GSK3B BNIP3L TNF CDKN2A BCL2L2 CSNK2A2 RELA IKBKB PRKCA BIRC2 TRAF2 FADD PMC5449392__F6 Proposed role of ARRB1, CALM3, FLNA and HTT in OSCC TRIO RALA FLNA RAC1 HTT PMC4382460__F2 IL-10 signaling pathways in normal and abnormal conditions STAT3 CD80 JAK1 TYK2 PMC5382327__F1 Fish retinoic acid‐inducible gene I (RIG‐I) ‐like receptor (RLR) ‐mediated signalling pathways in response to viral and bacterial infections TBK1 MAVS NOD2 IRF3 IRF7 RSAD2 TRAF3 PMC8431390__F1 Nucleic Acid Sensing in the Tumor Vasculature CGAS MAVS TREX1 PMC5352102__F2 Sirtuins in glucose and lipid metabolism IDE SIRT4 SIRT6 PMC5839385__F4 TAM pathway signaling in innate immune cells SOCS1 JUN RAF1 MAL IRF3 SOCS3 TRAF3 TRAF6 FOS MYD88 STAT1 ADAM17 GRB2 PMC4770763__F3 Subpathway-GMir: identifying miRNA-mediated metabolic subpathways by integrating condition-specific genes, microRNAs, and pathway topologies LPL HEL107 ENO2 GPAT2 FLJ10842 HEL-S-25 HEL-S-30 GPX8 PNLIP ALDH2 PGAM2 ENO3 COX2 DGKD FBP1 PTGES HEL-S-87p PMC7309569__F3 The dolichol-linked oligosaccharide (DLO) biosynthesis pathway ALG6 ALG1 ALG3 PMC11665856__F7 A working model of PFOA stimulation of lung cancer metastasis PXN PTEN SRC PMC9337267__F1 Targeting strategies in the treatment of fumarate hydratase deficient renal cell carcinoma FH ASL GLS KEAP1 EGFR PMC4380746__F1 Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention CD59 C5AR1 BCR HEL-S-62p LPO CR2 C4B_2 CR1 CP PMC6500672__F5 Putative suppressive pathway of Pj-ME in displaying its anti-inflammatory response STAT3 SYK TLR4 SRC MYD88 PMC6471124__F1 The MEK5–extracellular signal-regulated kinase 5 (ERK5) pathway with activators and downstream effectors CDC2 STAT3 FOXO3A GSK3B PML HIF1A IL1B FGF2 PMC6882186__F10 Proposed pathways for polysaccharide biosynthesis in Dendrobium moniliforme GMDS PMC2737000__F6 Androgen receptor pathway SVIL PLAGL1 BAG1 PTGS1 HSD11B1 PMC4320664__F3 Drug targets downstream of receptor tyrosine kinases involved in synovial sarcoma (RTK) DUSP10 BAX FBXW8 BAD EGR1 MCL1 GSK3B PTEN IGF1R ATF2 MTOR IRS1 TSC2 RICTOR TSC1 GRB10 FOXO3A BCL2 SS18 PMC2737000__F5 Arachidonic acid metabolism pathway DVL1 ALOX5 CROT CEBPD GSK3B PTGS1 PLA2G5 NR1C2 PLA2G12A PTGS2 CCNB1 PMC5123387__F24 (Abstract P2) TGFA RHO TEF PMC3367986__F2 Comparative Genomic Analysis of Soybean Flowering Genes RFWD2 MAF1 CRY1 PRR7 EFS CAT56 PRR9 ELF4 PAF1 MSI1 CRY2 AGL ELF3 PMC7865241__F7 Mechanistic scheme summarizing the anti-inflammatory effect of KMU-1170 NLRP3 TLR4 IL1B MYD88 PMC3104484__F5 Interplay between Wnt, Nurr1 and En1 signaling in vitro and in vivo EN1 CTNNB1 PMC9666723__F8 Digital gene expression profiling of the transcriptional response to Sclerotinia sclerotiorum and its antagonistic bacterium Bacillus amyloliquefaciens in soybean BMS1 POLL RAN UTP6 UTP4 TCOF1 IMP3 NMD3 DKC1 IMP4 NHP2 PWP2 NOB1 UTP18 NOP10 LSG1 POLI EMG1 NHP2L1 DRG1 NOP58 NOP56 PMC8946083__F7 In Silico Analysis of Ion Channels and Their Correlation with Epithelial to Mesenchymal Transition in Breast Cancer CDC42 EGFR TRPC1 PTEN MYC GRK4 GLRB KCNN1 KCNT1 GJA3 GRIN1 SRC MAPK1 CACNA1C JUN CACNA1B GJB2 ARHA KRAS FGF2 KCNJ10 HTR3C CLCN6 ITGB1 CDKN1A HEL-S-162eP TRPC6 GJA1 PMC7177247__F8 CBD blocks the IL-1B/IL-1RI/Beta-catenin pathway and induces an epithelial phenotype ID1 RAC1 BIRC3 PMC7260729__F8 RAP2.3 negatively regulates nitric oxide biosynthesis and related responses through a rheostat-like mechanism in Arabidopsis AOC2 PMC6116402__F2 Highly connected networks built using reperfusion-upregulated mRNAs coding for proteins known to interact with human proteins ZFP36 GATA2 JUN KLF6 JUNB PLAUR SOCS3 ITGB3 FOS ATF3 PPP1R15A DDIT3 FLT1 PMC6365711__F10 miRNA-223 may be an anticancer gene in NSCLC through the PI3K/AKT pathway by targeting EGFR BAX EGFR CCND1 PMC7764608__F5 NF-ĸB signaling pathway STAT3 SYK CD79B CD79A PIM2 PIM1 CARD11 IRAK1 MYC TRAF6 IRAK4 MYD88 CD44 BCR BCL2 RGS13 JAK1 PMC4288116__F4 Schematic illustrating the effect of p53 alteration on apoptotic pathway in basal-like breast cancer cells TRADD NFKBIA IRAK1 TNF FADD PMC4948960__F6 Pathway analysis of network signaling of some of the identified proteins as represented in the ingenuity pathway analysis database ZFP36 MAPK14 CEBPA MEOX1 RUNX1 SCARB1 MXD4 NFIB MNT MXD3 DUSP2 CLIP2 PMC5959262__F8 The protective mechanism of curcumin by the UPR-Nrf2 pathway after DAI BAX KEAP1 GSK3B ELF2 ATF4 PMC8461142__F1 Aryl hydrocarbon receptor (AHR) functions in infectious and sterile inflammation and NAD+-dependent metabolic adaptation SIRT3 NRK NAMPT SIRT1 PMC8218021__F3 Cross-Links of Endoplasmic Reticulum Stress, Autophagy, and Neurodegeneration in Parkinson’s Disease NBR1 ATG10 GABARAP ATG3 ATG16L1 ATG12 FOXO1 BCL2 ATF4 ATG5 TRAF2 PMC3080858__F6 PDP-1 Links the TGFB and IIS Pathways to Regulate Longevity, Development, and Metabolism IGF1 PPM2C SKI PMC9189345__F2 Research progress of endothelial‐mesenchymal transition in diabetic kidney disease GC SHH SMO CTNNB1 PMC8430824__F1 Ferroptosis and Synthetic Lethality Strategies VDAC3 SLC3A2 CDKN1A GPX4 DPP4 SLC7A11 GLS2 PMC9189345__F1 Research progress of endothelial‐mesenchymal transition in diabetic kidney disease SMAD2 APC SMAD4 CTNNB1 PMC9404924__F2 Potential Implications of Hydrogen Sulfide in Aging and Age-Related Diseases through the Lens of Mitohormesis DRP2 PINK1 MFN1 PMC9564314__F7 Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia STAT3 SRM MUC1 JAK1 PMC6249032__F2 Overview of Cdc5 functions in key cell cycle pathways CDC42 CDC2 CIB2 NET1 PMC9564314__F5 Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia EGFR SRM MUC1 TCF4 SRC MYC CCND1 CTNNB1 PMC2652867__F1 PML regulon model is used to explain the effects of the PML protein and PML nuclear bodies on survival signaling as described in the text CCNE1 GSK3B PML MDM2 MTOR SKP2 CCND1 EIF4E PMC4249369__F1 Pantothenate and coenzyme A biosynthetic pathway PANK4 PANK3 PANK1 COASY PMC2857326__F7 TGFB induces apoptosis in human B cells via transcriptional regulation of BIK and BCL-XL BAX FAS BCR TGFBR3 BIK FADD PMC6662984__F1 A2-3-sialyllactose showing PDB numbering C6 C4A PMC5825082__F7 Dysregulation of the IFN-Gamma-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia SOCS1 STAT3 STAT1 IRF1 JAK1 PMC9564314__F9 Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia EGFR GRB2 SRC PMC3973133__F6 Schematic showing actin cytoskeleton signaling pathways in adult hippocampal spines (see ) and the proposed mechanisms by which the glucocorticoid receptor (GR) affects actin assembly and stabilization CDC42 ARHA RHO PMC2128044__F12 Hierarchical representation of the JAK-STAT pathway with SOCS1 subsystem as a coordinator SOCS1 IFNG STAT1 PMC2276871__F1 Steroid receptor expression in postnatal day 5–10 developing prostates from oil-treated control rats (A) and neonatally estrogenized rats (B) RARA RXRA RXRB PMC3420817__F6 12-LIPOXYGENASE AND THE REGULATION OF HYPOXIA-INDUCIBLE FACTOR IN PROSTATE CANCER CELLS PTEN HIF1A MTOR PMC3509372__F1 Treg regulatory pathways ICOS CD80 CTLA4 FOXP3 PMC9110515__F1 White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure TLR4 CCL2 IRS1 PMC7565148__F7 Summary of WARS1 signaling pathway in macrophages SYK TLR4 CXCL2 MYD88 PMC6852217__F1 Genes encoding the enzymes involved in Vitamin D action and metabolic pathway NR1i1 CYP2R1 CYP27B1 CYP24A1 CYP27A1 PMC2722023__F4 Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program ACLY VNN1 RGS2 PPARG TMEM97 TNFRSF19 CHAC1 IKBKE MLXIPL ARF6 AACS RDH11 ENPP1 IRAK4 IKBKG MYD88 CLINT1 STAP2 ASAH2 RALA GGA2 RBP1 PDGFC AP2A2 LPXN TMED3 KHK KIFC3 ACOX1 CRAT MASP2 SNAP29 ORM1 BAG4 SREBF2 EXOC5 G0S2 RSAD2 FKBP5 RASA3 HMGCR HYOU1 C2 SLC7A7 PMVK CIDEC PRODH RET PMC7801281__F3 ROS production mediated by diverse signaling pathways GLUD1 ACSF2 LOX GPX4 LPCAT3 FACL4 CS PMC5729474__F4 The highlighted metabolic alterations in leiomyomas of the FH and MED12 subtypes HMOX1 MED12 FH ADSL PMC10474176__F6 NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway UBA3 CSF2 PDC CCL2 IL1B PMC2643067__F1 De novo purine biosynthesis pathway ADSL PMC5694536__F7 Schematic diagram depicting the role of Hoxa2 in proliferation and osteogenic differentiation of the palatal mesenchyme HOXA2 AIP SP7 RUNX2 PMC3082324__F7 Serpinin formation, its signaling pathway, and PN-1-dependent biogenesis of secretory granules in (neuro)endocrine cells CGA SP1 PMC5364965__F2 Notch gene signaling pathway interactions JAG2 NUMB LFNG DVL2 NOTCH2 HES7 HES1 NOTCH1 PMC8689194__F3 Endotoxin causes inflammation and leaky gut through activation of NFKB pathways CD14 TRAF6 LBP MYD88 PMC6620596__F2 STAT3 signaling pathway and inhibition approaches STAT3 EGF CPA1 EGFR IL6 SRC IL6R PMC7796296__F9 Involvement of the ERK/HIF-1A/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells CDH2 XCR1 XCL1 CTNNB1 PMC4195781__F1 Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia EVC KIF7 SUFU PMC3652284__F1 Regulation of Wnt/Beta-catenin Signaling within and from Osteocytes SOST APC LRP5 LRP6 SFRP1 PMC3252978__F7 Summary of the results presented in this study RAMP2 ARHA RAC1 PMC3314865__F3 Targeting Mutant BRAF in Melanoma: Current Status and Future Development of Combination Therapy Strategies PRKD3 ARAF RB1 BRAF NRAS PTEN MTOR PMC3024228__F1 General pathway for phosphatidylinositide (PI) synthesis PI3 PTEN PIKFYVE PMC7017348__F5 Multi-component feedback loops and multi-component signaling networks involving SNAIL and non-coding RNAs ZNF652 NUMB TCF4 IGF1R CTNNB1 PMC4461463__F1 Scheme for arginase catabolism of L-arginine to L-ornithine/urea or L-citrulline/NO, production of polyamines and anabolism and catabolism of proline ASL OTC PMC6232116__F2 Communality network analysis for k-clique 9 CDC42 EGF ATR TGFBI LEP EGFR ATF2 NCOA6 INS MAPK8 BLM RAC3 TOP3A RPA3 MMP2 ATM SRC CDK4 CDH2 CITED2 NBN MMP9 RBBP8 FOS FGF2 ERBB3 NR1C1 RELA CREBBP CDK2 BCL2 EP300 GRB2 KAT2B LCK PMC6232116__F4 Significant correlation of degree centrality between the OncoPPi BC network and our BC integrated network (p < 0.05), (r2 = 0.23688) CDC42 STAT3 PIK3CA STK11 HGF RAF1 SHC1 SOS1 ITGB4 EGFR GSK3B IL2RG SMAD4 MTOR INS MAPK8 MYC ITGAV CTNNB1 MAPK14 FGF7A FYN CDK6 ITGA6 CHUK IL2 SRC CCND1 CDK4 JUN RAC1 FOS IRS1 ERBB3 MLST8 CBL FOXO1 NFKB1 RPS6KB1 RELA IKBKB JAK1 PMC7582904__F2 Mechanisms for restoring HLA class I expression STAT1 EGF EGFR BRAF PMC5642705__F5 Macrophage response to cpsA deletion CCL22 TRADD CXCL1 IFIT1 IFIH1 CD1E CXCL2 IL1A ME1 CCL2 CXCL3 IFI44 DNA2 CCL7 MX2 MX1 CCL4 IFNB1 FADD PMC7490531__F7 Illustration of the IRE1-RIDD-miRNA Pathway in Luminal Breast Cancer Malignancy RAB3B XBP1 RET PMC3180262__F8 Hypothetical molecular signaling pathways of the expression of p27 by which moderate increase in the concentration of D-(+)-glucose down-regulates and deficiency of D-(+)-glucose or L-leucine up-regulates the expression of p27 SIRT3 EEF2K TSC2 TSC1 PMC4020998__F1 Apigenin Modulates Insulin-like Growth Factor Axis: Implications for Prevention and Therapy of Prostate Cancer RXRA SHE IRS1 PMC6082930__F3 Smurf2 as an oncogene EGFR GSK3B SMURF2 KRAS CTNNB1 PMC9348941__SF2 Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2 KEAP1 LPO TNF PMC4748851__F2 Neurofibromatosis type 2 CDC42 CD44 EIF3C EGFR RHO PMC8005619__F2 DNA Sensing pathways by herpesvirus CGAS IL16 IL18 AIM2 IRF3 PMC8005619__F1 Intracellular sensing of herpesvirus DNA by DNA sensors and activation of signaling pathway CGAS IL18 TLR9 AIM2 IFI16 IRF3 IRF7 IL1B MYD88 PMC9393484__F1 Motor, epileptic, and developmental phenotypes in genetic disorders affecting G protein coupled receptors-cAMP signaling HPCA GNAO1 DRD1 DRD2 PDE10A GNAL PMC6754303__F2 Pathogenesis and Clinical Features of the Acute Hepatic Porphyrias (AHPs) HMBS HMOX1 ALAS1 FECH PMC4176998__F9 Schematic diagram demonstrating speculated roles of ER stress signaling pathways in diabetic cardiomyopathy. Firstly, under pathological condition of hyperglycemia in myocytes, ROS is generated by glucose oxidation in mitochondria ATF4 EIF2A TRAF2 PMC5930467__F6 Verteporfin in bladder cancer cell LATS1 LATS2 ANKRD1 PMC3668775__F9 Proposed model for the attenuated response to type I IFNs in human pluripotent cells STAT2 IRF9 ISG15 JAK1 TYK2 PMC2943859__F5 Death receptor signaling and its interdigitation with the mitochondrial pathway of apoptosis FADD PMC9600385__F2 Melatonin and Indole-3-Acetic Acid Synergistically Regulate Plant Growth and Stress Resistance CAND2 MAPK6 MAPK3 PMC6590351__F4 Potential therapeutic target proposed to block leukaemia properties induced by the presence of CBFA2T3‐GLIS2 CBFA2T3 AURKA PMC6977166__F2 Overview of the affected pathways in the THP-1 cells after treatment with the free MTX and MTX loaded NPs GGH FPGS PMC10770036__F0 Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer TBK1 CGAS IRF3 B2M CCL5 CXCL10 PMC9246955__F2 Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-Beta-catenin pathway BAD MAK APP PMC9117704__F2 Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms STAT3 BAX PCNA BNIP3 PTEN PMC8503266__F1 Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects CDC42 CD44 PAK1 PMC4385926__F9 Simplified model depicting (a) Novel positive feedback loop between TGF-Beta-SMAD3 and KLF17 in cancer cells CADM1 MTDH SPARC KLF17 SATB1 PMC5278824__F1 Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives CPOX ABCB6 FECH UROD UROS PMC10955158__F5 FLRT3 and TGF‐B/SMAD4 signalling: Impacts on apoptosis, autophagy and ion channels in supraventricular tachycardia ALK NODAL FLRT3 PMC9117704__F5 Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms STAT3 PMC3159046__F6 Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood CDH8 TGFBR2 BMPR2 PCDH17 NFATC4 GSK3B FZD7 WNT7A CREBBP DAAM1 CTNNB1 TGFBR1 PMC8040227__F2 Canonical and non-canonical activation of NLRP3 TRADD NLRP3 IL16 IRAK1 TRAF6 TRAF2 IRAK4 PMC2083698__F6 Promiscuous Mutations Activate the Non-Canonical NF-kB Pathway in Multiple Myeloma LTB LTBR NFKB1 TRAF3 CYLD TRAF2 PMC10648520__F8 Brief Review of Bone Cell Function and Importance LRP5 LRP6 CTNNB1 PMC6028652__F7 Model of MAPK signaling pathway in MAP3K1; MAP2K4 wild-type or mutant cells JUN MAP2K4 MAP3K1 DUSP4 PMC8603984__F6 cGAS/STING: novel perspectives of the classic pathway BAX TBK1 CGAS PINK1 MLKL MCU IRF3 MTOR OPTN PMC8503266__F3 Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects LTB EGF RELB PMC8503266__F2 Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects LATS1 MOB1A LATS2 COX2 PTEN PTGS2 PMC7980590__F6 Flow chart for the functions of miR-4429 and DLX1 in PCa cells DLX1 IMPACT CTNNB1 PMC6258145__F6 Pictorial Abstract showing that the molecular or therapeutic inhibition of TRPM7 expression and/or activity attenuates the cancer stem cell-like and metastatic phenotypes of lung cancer cells through the modulation of the Hsp90A/uPA/MMP2 signaling CDH2 KLF4 TRPM7 SOX2 MMP2 PMC12056177__F10 Schematic description of kinase signaling pathways in Amyotrophic lateral sclerosis FUS TBK1 TTBK1 MLKL ULK1 PTEN RIPK3 NEK1 WDR41 RIPK1 VPS26B OPTN HEL-S-44 C9orf72 PMC3357548__F3 TWEAK signaling pathway: illustration of the TWEAK signaling pathway as visualized in NetSlim web page CAST JUN RELA RELB CHUK CCL2 TNF TWEAK FADD PMC3133775__F2 Second messengers and membrane trafficking direct and organize growth cone steering NGF DCC SEMA3A TRPC1 TRPC6 BDNF TRPC3 PMC8921770__F9 Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis DCSTAMP CTSK NFATC1 MMP9 ACP5 PMC8007973__F4 The Wnt pathway in normal tissue (A) and in our two pancreoblastoma cases (B) APC LRP5 LRP6 CTNNB1 PMC8229878__F3 Human Granulosa Cells—Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis CCS IGF1 CYP11A1 RUNX2 IRS1 PMC3539134__F2 Inhibition of insulin signaling pathway by SOCS1 and SOCS3 SOCS1 SOCS3 IRS1 PMC8087698__F1 Serine synthesis pathway (SSP) and downstream anabolic pathways PHGDH PSAT1 PSPH PMC7505148__F5 CORM-A1 on glycolysis and pentose phosphate pathway (PPP) metabolites in platelets HEL-S-133P F2 HEL-S-162eP PMC5143318__F7 In silico analysis of Noggin interactions with other proteins GDF5 BMP6 BMPR1A BMP4 NOG BMP2 BMP7 NKX2-5 BMP5 GATA4 GDF6 PMC8275408__F1 Mitochondria in Liver Ischemia-Reperfusion Injury: From Aspects of Mitochondrial Oxidative Stress, Mitochondrial Fission, Mitochondrial Membrane Permeable Transport Pore Formation, Mitophagy, and Mitochondria-Related Protective Measures HMGB1 TNF MYD88 PMC6591367__F7 Possible underlying mechanism of PAR4 signaling FOXO1 PTEN FOXP3 MTOR PMC7219893__F1 (Color online) A schematic overview of the indices of mindfulness and anxiety demonstrating their inverse relationship CRP LPP PMC9178270__F1 Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease TBK1 MAVS IRF3 PMC8947539__F1 Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions PRF1 ORAI1 MICA MICB PMC3763924__F1 Pathways of ICL repair REV1 FANCM FAN1 SLX4 PMC11048425__F5 Proposed metabolic routes associated with lipid and Beta-carotene biosynthetic pathways in ΔcarRP WJ11 in comparison with the WJ11 strain GLA NDP CIT PMC3805859__F1 Integration of microRNA and epigenetic regulation pathways HDAC1 AGO1 AGO2 TARBP2 EZH2 PMC8797156__F2 Research Progress on Leucine-Rich Alpha-2 Glycoprotein 1: A Review ALK SMAD2 ARHA PMC6156139__F2 Smad-dependent and Smad-independent pathways of TGFB signaling associated with EndMT SMURF1 SMAD2 GSK3B SMURF2 PMC5922974__F6 Genes directly effecting TAG biosynthesis in R ACLY FAS HEL-S-68p HEL-S-49 FBP1 NDE1 ENO1 MPC1 MPC2 PCK1 PMC4806601__F1 Genetic variants in the MicroRNA biosynthetic pathway Gemin3 and Gemin4 are associated with a risk of cancer: a meta-analysis AGO4 AGO1 AGO2 PMC9633197__F7 Molecular Mechanism of Epimedium Extract against Ischemic Stroke Based on Network Pharmacology and Experimental Validation TH STAR LIF PROC INS PMC3583293__F7 Model depicting how Shh promotes CGNP proliferation through combined effects on Gli1/2 and the mTOR pathway components eIF4E and S6K SHH SMO IRS1 EIF4E PMC4434964__F9 Models of EGF network and CNP/NPR2 signaling in the regulation of LH-induced ovulation NPPC EGF EGFR NPR2 CNP PMC9687797__F3 Epigenetics in the Development and Progression of Multiple Myeloma STAT3 ATF4 PMC7141597__F1 Division of labor between type I and type III IFNs in antiviral response IFNK IFNAR2 IFNAR1 IRF1 JAK1 TYK2 PMC3602699__F9 Summary of signaling pathway by which PP-fold peptides increase cell proliferation PYY NPY MTOR PMC4091682__F1 EGFR/PI3K Pathway STAT3 TSC2 EGFR PTEN MTOR CCNB1 PMC3399380__F2 IGF-IR signaling pathway GRB2 MTOR IRS1 PMC5401756__F5 Resistin signaling TIRAP TLR4 SOCS3 MYD88 PMC5401756__F4 Adiponectin signaling via AdipoR1 and AdipoR2 activation NR1C1 ADIPOR2 SOCS3 MTOR PMC12219892__F2 Scheme of the study design and workflow for transcriptomic and metabolomic analyses INHBA GEM SET PMC5401756__F6 Visfatin signaling STAT3 IL16 SIRT1 SIRT6 PMC2857646__F1 Schematic of the TGFB signaling pathway SMAD2 SMAD4 PMC4281710__F2 NOD2-interaction partners influence a wide range of NOD2 functions AAMP CAD MAVS ATG16L1 SOCS3 DUOX2 CARD6 RAC1 CARD8 NLRC4 ERBIN TRAF4 NLRP1 NLRP12 SLC15A3 NLRP3 SSH1 NOD2 OAS2 CARD9 PMC4281710__F1 The domain architecture of NOD1, NOD2 and RIP2 NOD2 NOD1 CARD6 PMC8959940__F1 Microglia Polarization: A Novel Target of Exosome for Stroke Treatment SMAD2 NFAT5 CH25H IRAK1 NOTCH1 PMC9255238__F1 An overview of resistance to Human epidermal growth factor receptor 2 (Her2) targeted therapies in breast cancer FAS HGF IGF1 CD36 EZH2 PTEN IGF1R MTOR SRC PMC6191506__F4 Hemoglobin production and redox homeostasis in erythrocytes CPOX ALAS2 FECH UROD UROS HEL-S-44 PMC4216012__F1 Wnt/Beta-Catenin Signaling Modulates Human Airway Sensitization Induced by B2-Adrenoceptor Stimulation FRAT1 APC ROR2 GSK3B LRP5 LRP6 RYK RHO DAAM1 CTNNB1 PMC2784766__F3 Complex role of the PLAU-PLAUR pathway in the airways TGFB1 SERPINE2 EGFR PLAUR PLG IL1A IL1B PMC4036353__F8 How TAZ/YAP direct TGFBeta-induced tumorigenic events SMAD2 SMAD4 NEGR1 PMC8470361__F1 Glycogen Synthase Kinase-3: A Focal Point for Advancing Pathogenic Inflammation in Depression STAT3 TLR4 BDNF PMC7976442__F5 Kyoto Encyclopedia of Genes and Genomes analysis of predicted pathways SYK CA12 AVPR2 KDR PMC4983259__F1 O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling ACLY OGA OGT HEL-S-133P HK2 FASN PTEN MTOR PMC5401756__F2 Leptin signal transduction STAT3 SOCS3 PMC3634068__F6 Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters ACLY DDT CYP3A7 CYP24A1 CYP2B6 RXRA CYP2C9 ALAS1 ABCC2 PMC5968197__F6 Dual-lock for G1-phase arrest in unfertilized mature starfish eggs CDC2 MOS CDC45 PMC4176051__F2 Pathway analysis CREG1 SLC39A1 NDRG2 MYOF E2F8 CRB3 COL9A1 GFPT1 CALML4 MYBPC3 SGCA PMC6506414__F14 N-Linked glycan (A) and the calnexin cycle (B) UGGT1 EDEM3 EDEM1 EDEM2 PMC5968197__F9 MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes CDC2 ENSA ARPP19 WEE1 MYT1 PMC6952935__F1 Schematic representation of the metastatic cascade CD248 VEGFA PMC5389954__F2 Synthetic diagram of opposing effects of PPAR gamma and canonical WNT/beta-catenin signaling in cancer HEL-S-133P GSK3B MYC CTNNB1 PMC9657779__F10 Regulatory Role of Sphingosine-1-Phosphate and C16:0 Ceramide, in Immunogenic Cell Death of Colon Cancer Cells Induced by Bak/Bax-Activation BAX SPHK1 TRAF2 PMC5389954__F1 Schema of interactions between the canonical WNT/beta-catenin pathway and PPAR gamma under aerobic glycolysis conditions in cancer HEL-S-133P APC LRP5 LRP6 MB MYC CTNNB1 PMC3076924__F2 Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders CASP3 MTOR BDNF PMC3076924__F4 Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders ATF4 EIF2A XBP1 TRAF2 HEL-S-44 PMC7353017__F1 EGFR (epidermal growth factor receptor) and VEGFR (vascular endothelial growth factor receptor) signalization pathways HRAS EGF PIGF EGFR BRAF NRAS TFG PTEN MTOR KRAS PMC3433406__F5 Large scale phosphoproteome analysis of LNCaP human prostate cancer cells TPD52L2 RFC1 CLNS1A ABCC1 CANX MYEF2 THRAP3 CTNND1 SSR1 SMN1 CSTF3 NUMA1 HUWE1 CTNNB1 IGF2R NUFIP2 FIP1L1 NOLC1 HNRNPH1 KRI1 DHX16 MYH9 NPM1 HDAC2 SRSF9 NSUN2 FXR2 TLE3 MAP4 KHSRP YBX1 KTN1 MDC1 SSB XPC BCLAF1 TP53BP1 MCM7 SF1 MORC2 HEL-S-102 RBM17 CTNNA1 PMC6327716__F6 The ubiquitylation of glycoprotein (GP) VI signalling pathway SYK BTK FYN PLCG2 LYN SRC PMC2777484__F1 Folate-mediated 1-carbon metabolism DHFR SHMT1 TYMS PMC6095079__F3 Findings of network and pathway analysis KLRC2 KIR2DL4 KRT1 TMOD1 TGFBR3 FCGR1A ALAS2 IFNG BCL2L1 PRF1 BCR KIR2DL3 GNLY MYBL1 PMC8402498__F11 Escherichia coli Alpha-Hemolysin HlyA Induces Host Cell Polarity Changes, Epithelial Barrier Dysfunction and Cell Detachment in Human Colon Carcinoma Caco-2 Cell Model via PTEN-Dependent Dysregulation of Cell Junctions HEL114 COMP CRB3 RAB13 PTEN CASK RHO PMC8402498__F10 Escherichia coli Alpha-Hemolysin HlyA Induces Host Cell Polarity Changes, Epithelial Barrier Dysfunction and Cell Detachment in Human Colon Carcinoma Caco-2 Cell Model via PTEN-Dependent Dysregulation of Cell Junctions MAST2 BAD PTEN PMC7092476__F6 Signaling pathway enrichment analysis of core targets of TWH for CD TH TNF FADD PMC4550442__F3 Acetylation of IFNAR-ISGF3 pathway is required for the antiviral activity of IFNA STAT2 IFNAR2 IRF9 IFNAR1 PMC4085347__F4 A mechanism showing tyrosine kinase receptor induced regulation of Nrf2 nuclear–cytoplasmic shuttling under redox homeostasis conditions GSK3B LYN SRC PMC4085347__F3 Diagrammatic presentation of regulation of Keap1-Nrf2-ARE pathway JUN MAF SI KPNA6 PMC9271918__F2 Molecular Mechanisms of Plant Responses to Salt Stress BIN2 SNRK BAK1 PMC9271918__F1 Molecular Mechanisms of Plant Responses to Salt Stress BIN2 SOS1 SOS2 PMC8435612__F2 Long Non-coding RNAs in Pathogenesis of Neurodegenerative Diseases FZD3 GSK3B IL18 APP IL6 PMC7054735__F1 Therapeutic approaches for osteogenesis imperfecta SOST LRP5 MSC CTNNB1 PMC4464465__F4 Balance of inflammatory pathways and interplay of immune cells in the liver during homeostasis and injury BAX TRADD TNF TRAF2 FADD PMC6298633__F13 Schematic illustrating the potential contributions of ADAM9 (a disintegrin and metalloproteinase domain-9) to various chronic obstructive pulmonary disease phenotypes ADAM9 CCL3 EGFR PMC11857241__F2 Our manuscript denotes the neuroprotective effects of many phytochemical classes, including those from flavonoids and alkaloids, against neurodegeneration SOCS1 NLRP3 SIRT1 PMC7904598__F2 Bi-directional EV-mediated communication between astrocytes and glioblastoma cells STAT3 GFAP IL16 PMC11857241__F1 During neurodegeneration, critical pro-inflammatory and oxidative molecular pathways are involved in the occurrence of neurodegenerative conditions VCAM1 TNF SIRT1 PMC4412741__F2 Effect of Antibodies on Endothelium CD59 GAL RICTOR RHO MTOR SRC PMC4412741__F1 Effect of Antibodies on Endothelium VWF RHO SRC PMC7785707__F7 Proposed molecular mechanisms MAF1 GSDMD NLRP3 BCL2 PMC4204167__F2 The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor E2-related factor 2 (Nrf2)-antioxidant response elements (ARE) signaling pathway KEAP1 MAF PMC10707854__F3 Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis COL1A1 APC GSK3B CTNNB1 PMC7589024__F10 Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐KB and TNF‐A/TNFR1/NF‐KB pathways HMGB1 TLR4 TNF TRAF2 IL1B MYD88 PMC10707854__F2 Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis SMAD2 SMAD4 PMC10242070__F5 Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages CYP1A2 STAT3 TLR9 IRF1 IL21R TLR5 CD84 IRF3 IRF7 CYP1B1 CYP1A1 RUNX3 IDO2 SPINT1 AHR STAT4 FCGRT PMC4734677__F6 Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye VEGFC DLL4 NOTCH1 PMC5919962__F1 Platelet targeted therapeutics TF VWF GP1BA COX1 SAP18 PLG VTN HEL-S-11 LYN RHO SRC OTP PMC5192336__F2 MUC induces inflammasome activation NLRP3 TXNIP IL16 PMC7704135__F5 Neuroactive ligand-receptor interaction signaling pathway PMCH VIP TH ATR GAL LEP LHB TACR2 GHRL GRN TACR3 CALCR APELA AFP NPFF PRL UTS2 DAP NPY PTH SCT GHR PMC9515687__F3 Inflammasome NLPR3 in the Development and Therapy of Periodontitis GSDMD NLRP3 IL1B BRCC3 PMC5214768__F8 Interaction map representing CNV-altered genes enriched in GO classes and grouped on the basis of their main biological processes TH LHX1 PCLO SNAP29 TCF2 KCNJ12 GRN SLC5A7 PPP1R8 GNB1L TCF3 RTN4R FPRL2 GRIP1 KNS2 BCL2 WNT3 DACH1 NRXN1 PSMG1 NAT8L SYT15 PMC8761767__F1 Interleukin-33/ Suppression of Tumorigenicity 2 in Renal Fibrosis: Emerging Roles in Prognosis and Treatment ACTA2 IL33 SIGIRR ATF2 TRAF6 CCL2 IRAK4 MYD88 PMC8358430__F1 Inflammatory Cytokine Storms by Mesenchymal Stem Cells STAT3 CASP3 MSC PMC7495247__F1 A) Schematic showing how COVID-19 triggers hyper-activation of the immune-response, generating a cytokine storm LTB COX1 COX2 C2 PMC7677509__F6 Cyclin G2 inhibiting the growth and metastasis of OSCC by binding to IGFBP3 and regulating the FAK-SRC-STAT signal pathway STAT3 CCNG2 MMP9 SRC PMC3896626__F2 Interaction among differentially modulated genes in the apoptosis biochemical pathway, using KEGG, after hgf-FNDF-LC50 and SCFA-LC50 treatments BAX NGF BAD FAS CASP6 TRADD IL3 BCL2 ATM TNF FADD PMC3896626__F1 Interaction among differentially modulated genes in the cell cycle biochemical pathway, using KEGG, after hgf-FNDF-LC50 and SCFA-LC50 treatments DBF4 PCNA CDC6 SMC3 SMAD4 ORC1L MYT1 ORC3 SKP2 ORC2 RAD21 CDK7 E2F4 CDC45 CDK2 MDM2 PMC10951222__F5 Tumor evolutionary analysis and clinical vignettes for patients who derived clinical benefit from palbociclib, everolimus, and exemestane triplet therapy PIK3CA KMT2C NF1 ERBB2 PMC9351107__F3 Targeting KRAS mutant cancers: from druggable therapy to drug resistance SOS1 MTOR KRAS PMC4686785__F8 PPI human module PLCD3 RGS2 SPAG1 NCALD DLGAP2 WASF3 ACCN3 AGAP2 TRPC7 TRPC1 PFKFB2 PTEN RHO GRID2 PRKCB APBA1 ITPKA PRKCE PLCG2 TNP2 APP ITPR2 GRIA4 DGKZ LRRC7 NRGN SEMA4C HOMER1 TNP1 ARFGEF2 CRIPT PLCH2 CCL14 MAGI3 GLS2 AKAP12 TRPC6 PRKG1 ERAS PMC4012889__F1 Intricate network of TLR signaling and miRNAs DGCR8 MAP3K7IP1 TLR4 IRAK1 TRAF6 DROSHA IRAK4 MYD88 PMC8913022__F2 Statin Use in Patients With Chronic Liver Disease and Cirrhosis: Current Evidence and Future Directions CDC42 KLF2 RAC1 PMC11506310__F2 Non-canonical TRAIL signaling pathway RIPK3 STAT3 MLKL RIPK1 ATF2 SRC TRAF2 RAC1 FADD PMC8762167__F1 Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells BAX BAD NQO1 SOX2 DMBT1 HEL-S-44 PMC11506310__F1 TRAIL-induced pro-apoptotic signaling pathway BAX APAF1 FADD PMC6859927__F1 Representation of normal BRAF pathway POR BRAF PMC2878746__F1 Ret gene structure and signaling PSPN ARTN FRS2 NRTN SRC RET PMC2633625__F2 Toll-like receptors in skin TLR1 TLR3 TIRAP TLR4 TLR9 TLR5 IRF3 TLR7 TRAF6 IRAK4 MYD88 PMC6425986__F4 Proteomic Analysis of the Human Anterior Pituitary Gland OTOR SI PMC3913963__F5 Beta-adrenergic signaling modulates multiple cellular processes in tumor progression and metastasis STAT3 BAD RAP1A MTOR PMC2649725__F7 Model showing the activation of the JNK pathway upon challenge by UVB CAD H2AX ROCK1 PMC4530868__F4 MicroRNA and Transcription Factor Mediated Regulatory Network Analysis Reveals Critical Regulators and Regulatory Modules in Myocardial Infarction STAT3 TIMP3 SP1 TRADD TNFSF6 RELA TRAF5 COL4A1 MMP2 PTEN VEGFA TRAF2 PMC4594993__F6 General model for basigin promotes the membrane localization of CD98 and activation of B1-integrin HOOK1 RAB11A ARF6 RAB22A PMC7865797__F1 Carbon-source preferences and use in cancer metabolism HEL-S-133P PHGDH SCD PC PMC4167483__F2 Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome EGF SUFU GSK3B LRP5 LRP6 SMO MTOR TNF CCND1 PMC4167483__F1 Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome EVC2 EVC HHIP KIF7 SUFU SMO EFCAB7 CCND1 PMC10835878__F10 Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells TFAM HEL-S-133P HK2 MTOR PMC3915736__F2 Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy KLF2 ID2 CD27 PRDM1 APC MTOR BCL6 PMC5342493__F5 Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma TGFB1 SMAD2 NRP1 PMC8396170__F2 RasV12; scrib−/− Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions MMP12 FER SCRIB SRC PMC4326575__F1 Structure and signaling from the cilium and relationship with the autophagic pathway ULK1 PDGFRA IFT20 SMO MTOR ATG5 PMC6534064__F1 Drugs targeting Wnt/beta-catenin signaling in Desmoid-Type Fibromatosis SOX11 APC LRP5 ADAM12 LRP6 CTNNB1 PMC1569532__F1 Different types of regulatory T cells ITCH FOXP3 PMC6534064__F2 A schematic presentation of the Hedgehog signaling pathway and the drugs that interfere with this pathway in DTF SHB HHIP DHH SHH IHH SMO PMC8088752__F7 Integrated stress response-mediated activation of mammalian RNA-dependent mRNA amplification ATF5 DELE1 ELF2 OMA1 ATF4 PMC4559166__F1 Time-series transcriptome analysis for adaptive evolution of E RPE SDHA RPIA CIT PMC7663714__F2 Interplay between different proangiogenic factors and their corresponding modulatory microRNAs MMP7 STAT3 PIGF FRS2 MMP2 MMP9 VEGFA FGF2 PMC8962276__F1 Uremic Toxin Lanthionine Induces Endothelial Cell Mineralization In Vitro ALPL ANKH BMP2 RUNX2 PMC6959318__F7 Model illustrating possible functions of DGAT1 and DGAT2 in human skeletal muscle cells FAS DGAT1 DGAT2 PMC7140640__F4 Molecular pathways of the unfolded protein response (UPR ATF4 EIF2A XBP1 PMC9438316__F1 Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma ACLY FAS GLS HEL-S-162eP CD63 PMC2674807__F2 Common polymorphisms in the genes associated with Alzheimer’s Disease (AD) LPL IDE NTS SORL1 APOE GSK3B SNCA TNF MME CASP3 C9 A2M APP PMC6055827__F4 Lipopolysaccharide (LPS)‐ and serum amyloid A (SAA)‐mediated cellular production of inflammatory cytokines TBK1 TLR1 TLR4 MAL IRAK1 TLR5 IRF3 IRAK2 TRAF3 TRAF6 IRAK4 MYD88 PMC9438316__F2 Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma STOML2 HEL-S-133P PHGDH HEL-S-162eP NEK2 LDHB PMC4783980__F2 Inhibition of Calcium-induced T Lymphocyte Apoptosis pathway PLCG1 CABIN1 MEF2D PMC2654747__F2 Summary of enzyme-catalyzed thyronamine deiodinase reactions DIO1 PMC9711860__F7 Illustration of how loss of cell–cell adhesion triggers cell migration STAT3 HEL113 TIAM1 SRC RAC1 PMC8694526__F2 Recent Advances in Osteoclast Biological Behavior RHEB TEC TREM2 SYK TSC2 BTK TSC1 OSCAR BLNK GRB2 PMC3946634__F1 Tumor suppressive signatures of miR-200 SUZ12 CDK6 MAML3 SOX2 ZEB2 GATA4 CCND1 MAML2 PMC9198352__F2 Strategies of LncRNA DLX6-AS1 on Study and Therapeutics FUS MAP4K1 DLX6 MTOR DLX5 PMC4220515__F1 Excess glucose and fatty-acid exposure linked to reduction of AMPK and consequent inflammation and fibrosis APPL1 ADIPOR1 SMAD4 PMC4590251__F1 PirB-mediated growth cone collapse and axon growth inhibition.A classical axon inhibition signaling pathway: Nogo on the oligodendrocyte surface binds to the NgR-LINGO1-P75 receptor complex on the neuronal membrane LINGO1 ARHA RHO PMC7564842__F1 Receptors and signaling pathways that activate the NFKB cascade TRAF6 TRAF2 IRAK4 MYD88 PMC5589138__F2 Normal and abnormal adrenal steroidogenesis in the zona fasciculata CYP21A2 CYP17A1 PMC3442804__F2 Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter HRAS EGF FADD PMC11989151__F9 Canonical MC1R signaling pathway MC1R RXRA SRC PMC4186703__F9 Non-Classical Renin-Angiotensin System and Renal Function ACE2 PMC8906937__F6 Solasonine Induces Apoptosis and Inhibits Proliferation of Bladder Cancer Cells by Suppressing NRP1 Expression EGF EGFR MTOR VEGFA PMC8195803__F3 Revisiting the role of mitochondria in spinal muscular atrophy VPS13D NCALD PGAM5 MFN2 PMC6323673__F7 Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line ZFP36 CARNS1 EDN2 RBCK1 PMC9405302__F5 Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants KEAP1 APC ME1 CTLA4 HEL-S-26 PMC2819585__F7 MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis PRC1 EZH2 PMC8280619__F1 Unraveling the role of liver sinusoidal endothelial cells in COVID-19 liver injury VWF CXCL1 CXCL2 PMC7791639__F7 Bleomycin induces fibrotic transformation of bone marrow stromal cells to treat height loss of intervertebral disc through the TGFBR1/Smad2/3 pathway COL1A1 SMAD2 MSC ADAMTS5 SMAD4 MMP3 COL3A1 CCND1 TGFBR1 PMC7767860__F2 Canonical and non-canonical pathways of TGFB signaling SMAD1 DKFZp781O1323 SMAD2 SMAD6 SMAD4 MTOR SKI PMC3427792__F1 Akt isoforms and glucose homeostasis - the leptin connection RHEB TSC2 TSC1 IGF1 SESN3 EIF4E PMC4569842__F1 Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine ACO2 ARG2 CIT PMC11649616__F3 Cancer-associated fibroblasts crosstalk with extracellular matrix LATS1 LATS2 SMAD2 G3BP2 SMAD4 MYC PMC6770863__F1 TLR4–p38B MAPK–C/EBPB signaling pathway mediates the coordinate activation of UPP and ALP in cancer-induced muscle catabolism GABARAPL1 TIRAP ULK1 TLR4 TRAF6 MYD88 PMC8836041__F2 Autophagy by the Glycogen Synthase Kinase-3 (GSK-3) Signaling Pathway GSK3B TFEB PMC5330258__F1 VD3 is metabolized to 25(OH)D3 and 1,25(OH)2D3 by the classical pathway or to 20S(OH)D3 and 20S,23(OH)2D3 by CYP11A1 CYP2R1 CYP27B1 CYP11A1 CYP27A1 PMC3954635__F4 Beta-catenin pathway HINT1 ANXA6 SMAD2 APC DMBT1 SMN1 FANCA CTNNB1 NMUR2 PIGF FOXF1 PRKCE PPP2R2B SNCG TACR1 PC BCL2 ZC3H18 LAMA3 PMC9332053__F2 MTOR Signaling Pathway in Multiple Sclerosis; from Animal Models to Human Data CD40 NLRP3 BCR MOS APC MTOR PMC9332053__F1 MTOR Signaling Pathway in Multiple Sclerosis; from Animal Models to Human Data RHEB MLST8 RICTOR TSC1 SGK1 BPI MTOR DEPTOR IL1B PMC6143528__F8 Action of OR2AT4 activation by Sandalore® and (unknown) endogenous ligand(s) in human hair follicle epithelium OR2AT4 BAX HBEGF BAD IGF1 c-fgr DIPLA1 EGFR IGFBP4 BCL2 IGF1R MDM2 PMC3718392__F2 Targeting of PI3K/mTORC1 signaling in hamartoma syndromes RHEB TSC2 TSC1 PTEN CS PMC3718392__F1 mTORC1 signaling RHEB TSC2 TSC1 PTEN IRS1 PMC8899613__F8 Plasma Proteome Profiling of Patients With In-stent Restenosis by Tandem Mass Tag-Based Quantitative Proteomics Approach LPL TRO APOD MOS PLTP PMC11204099__F8 Chlorogenic acid and cinnamaldehyde synergism on Akt-mediated signaling pathway downstream target proteins CDH2 MMP9 PMC3844273__F6 Hypothetical estrogen signaling pathways in human cerebral vascular endothelial cells TF HBEGF EGFR PMC6771382__F2 Summary of HR processes and HR proteins reported for sumoylation and interacting with SUMO RAD52 RAD51 SIX1 SIX3 SIX4 SIX2 SLX4 RMI1 PMC6888459__F3 Intracellular trafficking of EAAT3 NUMB SORCS2 PMC6122073__F4 Single-strand break signaling TOPBP1 ATR ATRIP PCNA H2AX ATM SSB PMC3718996__F8 Graphs showing the different regulation of glioma cell signaling when cells were cultured on biomatrix, myelin and unmyelinated tissue (retina) ROCK2 LIMK2 LIMK1 ARHA PMC8342223__F3 Complex role of AIM2 in autoimmune diseases and cancers IF2B1 MFN2 AIM2 MTOR IL1B PMC7649293__F5 An Msx2-Sp6-Follistatin Pathway Operates During Late Stages of Tooth Development to Control Amelogenesis FST MSX2 PMC5598536__F2 Canonical pathway illustrations of CBA classifier FTL GCLC MAF PMC4977872__F9 Hypothesis of “The regulation of H3K27me3 on S IFNG IL10 B2M CXCL10 PMC11641149__F1 Regulatory factors of mitochondrial dynamics, associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD) PINK1 LRRK2 MFN1 MFN2 MFF PMC5331536__F8 LSS improves cognitive function and prevents neuronal injury of AD rats via inhibiting the neuronal apoptosis signaling pathway BAX BAD PMC6916339__F2 SHIP2 regulates the insulin signalling pathway PI3 CD2AP PTEN PMC3262611__F1 Folic acid metabolism DHFR PMC3377643__F2 TGFB and Iron Differently Alter HBV Replication in Human Hepatocytes through TGFB/BMP Signaling and Cellular MicroRNA Expression NR1i1 SMAD2 TLX2 GSC NODAL GRB2 TRAF6 HOXC8 RUNX2 SKI PITX2 RUNX3 PMC8199207__F2 Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers CGAS IRF3 PMC8199207__F1 Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers CD80 IL10 CTNNB1 PMC6550542__F2 Interplay between enteroviruses and the host autophagy pathway NBR1 SNAP29 CALCOCO2 PMC7299703__F8 Apoptotic signalling pathway BAD CAD APP FAP PMC7747089__F1 Induction of type I IFNs and ISGs by influenza virus STAT1 MAVS STAT2 NOD2 OASL CH25H IRF1 IRF3 IRF7 JAK1 TYK2 MYD88 PMC6198670__F5 ARG1-arginine-immune suppression-fatigue pathway CD27 IL13 CCR7 IL4 ARG1 PMC10528430__F1 Microglial responses in Alzheimer’s Disease STAT3 SYK NDUFA9 HEL-S-62p IL33 MTOR ITGAX CR1 TREM2 STAT1 CD74 CX3CR1 CD33 TLR4 TMEM119 CSF1R LPL HEL-S-2 CST7 APOE LDHB HEL-S-30 TNF PAX6 P2RY13 PMC8107375__F5 Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells TMPRSS2 TLR3 CXCL10 ACE2 PMC3845396__F1 Regulation of AKT signalling activation CASP9 BAD PTEN MDM2 MTOR PMC6937972__F6 Strong association of calcium channel activity in NRXN1A+/− iPSC-derived neurons PMCH RASGRF1 TNC CACNG3 CXCL12 FGF12 F2RL2 ITGB4 SDC4 NMU TGFBR2 CACNA1I CHRNB2 GRIN3B PROS1 APLN HRH1 HCRTR2 PPP2R2C CACNA1A CAV2 CACNG2 GNG4 PDGFA PMP22 FGF6B TGFBR3 CHRM2 PDGFRA CACNA2D1 RRAS ADCY1 CORO1A GJA1 TRPC3 PMC7934421__F1 Molecular pathomechanism of CRP-mediated damage in ischemic or hypoxemic tissue CRP FH HEL-S-62p C2 PC C4A C4B_2 PMC4863537__F1 Pharmacology and rationale for imatinib in the treatment of scleroderma SMAD2 SMAD4 SRC PMC4591505__F1 TCR-mediated integrin activation inside-out signaling PLCG1 HEL-S-81p LAT PMC9035407__F10 RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein RGS14 NHERF1 SGK1 PTH FGF23 PMC5879088__F1 Canonical leptin signaling in hypothalamic neurons STAT3 POMC AgRP NOX4 PMC3287363__F7 Working model of ID/anemia-suppressed hippocampal IGF signaling TSC2 FOXO1 HIF1A IGF1R MTOR IRS1 PMC4166762__F1 Glucagon-like peptide 2 receptor (Glp2r)-induced intracellular signaling in hypothalamic proopiomelanocortin (POMC) neurons INSR LEPR POMC PMC7797159__F6 Cis- and trans-networks of DEGs and DE-lncRNAs of muscle development-related GO terms and signaling pathways RPS6KA6 TAOK1 DUSP8 SHOX SOS1 CRKL TAOK3 WNT4 GRB2 NLK MEF2C PMC5791065__F1 Activation of the B cell receptor signaling canonical pathway in FCRx versus SIS: a schematic representation CDC42 SYK BAD EGR1 CD22 BLNK PTEN CD19 MTOR TCF3 BTK FOXO1 PAX5 APBB1IP CSK LYN GRB2 BCL6 UNK PMC8456902__F2 Estrogens in polycystic liver disease: A target for future therapies? EGFR PGRMC2 GPER PGRMC1 SRC PMC8716792__F3 Ferroptosis Signaling and Regulators in Atherosclerosis LATS1 LATS2 SLC7A1 GLS2 NOX4 PMC8716792__F2 Ferroptosis Signaling and Regulators in Atherosclerosis TF GPX4 MAF PMC5669621__F1 Development of POMC neurons STAT3 CNTF SIX3 NKX2-1 POMC SOX2 SHH NPY BDNF RAX HES1 PMC9361782__F7 Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma CYP26B1 CASP9 HEL-S-53e RBP4 VEGFA RDH11 RARA ALDH1A3 RBP2 FABP5 BTG2 DHRS9 RARB CRABP2 RBP1 DHRS4 RDH10 RDH5 ALDH1A2 ALDH8A1 GJA1 CCND1 DHRS3 RBP7 PMC8002083__F8 Illustrated model for our proposed molecular mechanism of how moscatilin inhibits HCC cell metastasis through inhibiting uPA expression via down-regulating Akt/NFKB signaling pathway HCCS PLG PMC6274847__F2 Proline, ornithine, and arginine metabolism and transport in plants PRODH2 OTC CIT PMC6299256__F3 IL-27 induction by C STAT1 STAT2 IFNAR2 IFNAR1 NOD2 TLR7 MYD88 PMC6999710__F1 Mitophagy and Innate Immunity in Infection USP35 NBR1 USP30 PHB2 TBK1 PINK1 MFN2 BNIP3 FUNDC1 OPTN PMC3808116__F2 Schematic overview of multiple feedback loops in the PI3K pathway PTEN IRS1 PMC10526229__F1 Notch Signaling by Small-Molecular Compounds and Its Potential in Anticancer Studies DLL4 SI MTOR NOTCH2 NOTCH3 FURIN DLL3 PMC8589993__F5 Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer IL15 EGF MMP14 CSF1 TIRAP EGFR TAB3 TRAF3 TRAF6 MYD88 NGF BCL2L1 TLR4 IL18 MMP3 JUN CSF2 SELE CD14 PTGS2 MMP9 TNF RAC1 FOS PARP1 CNTF HBEGF TLR1 MAP3K7IP1 PAK1 RELA CASP3 NFKBIA BCL2 TRAF1 VCAM1 TRAF2 FADD PMC9019162__F3 Genome-Wide Association Study for Tolerance to Paratuberculosis Identifies Candidate Genes Involved in DNA Packaging, DNA Damage Repair, Innate Immunity, and Pathogen Persistence SOCS1 ERCC1 PRM3 PRM2 MHC2TA CREB5 P1 TNP2 TRAF5 CHUK TNF PMC11241191__F7 Schematic illustration of SRI regulating apoptosis in HCC STAT3 SRI BCL2 PMC6909887__F1 Mechanistic Target Of Rapamycin Complex 1 (mTORC1) signaling pathway with areas of potential pharmaceutical inhibition highlighted RHEB CASTOR1 SLC38A9 PMC2631022__F1 ECM-receptor interaction pathway enriched by human switch-like genes CD44 VWF CD36 CHAD CD47 PMC8120246__F6 Dissecting the Roles of LncRNAs in the Development of Periventricular White Matter Damage SOCS1 PPARG SYK CSF1 TGFB1 NFATC2 NFKB2 AKT3 FHL2 PPP3CA MAPK8 IKBKG TGFBR1 TREM2 IFNG STAT1 IL1R1 FOSL2 BTK FYN PLCG2 CHUK CYLD CREB1 CSF1R ACP5 IRF9 SIRPB1 CTSK OSCAR BLNK NCF4 NFATC1 FCGR1A IL1A ITGB3 TNF FOS CALCR MAP3K7IP1 IKBKB NFKBIA JAK1 IFNB1 TRAF2 GAB2 PMC6491894__F1 Deletion of both cytosolic superoxide dismutases impacts metabolite concentrations and enzyme abundance of TCA cycle (A), glycolysis (B), and pentose phosphate pathway (C) SDHD RPE SDHA SDHB RPIA MAL SDHC CIT PMC5869054__F5 ABeta-driven Wnt-PCP pathway activation EGR1 GSK3A DKK1 NAB2 LRP6 KLF10 ARHA DAAM1 CTNNB1 PMC4752324__F8 Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension PCNA PAH NOX4 PMC12176845__F5 CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) STAT3 LIF PMC12176845__F4 CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) PTEN MTOR VEGFA PMC12176845__F3 CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) LTBP2 SMAD2 SMAD4 TRAF6 PMC5300981__F3 TGFBeta-Smad signaling pathway in HSC SMAD2 SMAD4 TGFBR1 PMC11727080__F1 Fate of glucose and fatty acids in macrophages and HCC cells ACLY FAS CIC HK2 CS CPT2 HEL-75 PMC11727080__F2 Crossroad in amino acid metabolism in macrophages and HCC cells ASL HK2 GC ARG1 ORC1L SLC7A2 ORC2 PMC3628764__F1 Alternate routes of endocytic traffic of activated tyrosine kinase coupled cell surface receptors and the role of Cbl-family protein dependent ubiquitination EGF CBL EGFR PMC9456329__F8 Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells HMGB1 HEL-S-128m NLRP3 MAF PMC4032345__F3 Comparative Proteomic Analyses Provide New Insights into Low Phosphorus Stress Responses in Maize Leaves HEL-S-162eP GIP PMC8998804__F1 Transcription Factors with Targeting Potential in Gliomas TF POR STAT3 FOXM1 EGFR SMO PMC7379485__F7 ALDHHIGH cells regulatory mechanisms in cervical cancer cells GSK3B LRP6 CTNNB1 PMC11739089__F6 Research progress on the synthesis process, detection method, pharmacological effects and application of glycocholic acid LTB LTA LOX COX1 PMC5848464__F1 Regulation of canonical and noncanonical pathways of NFKB activation by cylindromatosis (CYLD) CD40 LTBR RELA RELB TRAF3 CYLD CCND1 TRAF2 PMC3941170__F2 Cell cycle regulation by p16Ink4b/p14ARF CDK6 MDM2 CDK4 PMC11897346__F7 Graph model for the role of SR-A3 in protecting against MAFLD through the XIAP/PTEN/AKT axis PTEN MTOR PMC8843879__F3 Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential KLF6 PMC5641214__F2 Leptomeningeal disease: current diagnostic and therapeutic strategies PNP DHFR GGH FPGS PMC8997752__F5 Beyond PD-L1—Identification of Further Potential Therapeutic Targets in Oral Cancer CD80 PMC6424911__F4 Changes in transcripts related to phenylpropanoid metabolism in response to aphid feeding in susceptible plants CAD PTS PMC6186589__F1 Schema of sortilin regulating EGFR trafficking () ROR1 AGR2 EGFR RAB35 RHO MTOR PMC6800172__F1 Chemical structures (Panel A) of decursin (D), decursinol angelate (DA) and decursinol (DOH), and likely metabolic pathway (Panel B) of D and DA based on rodent data and human studies in vitro and in vivo CES2 CYP2C19 CYP3A4 PMC9163565__F3 New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain GDF3 IGF1 ACCN3 CX3CR1 TLR4 CCR2 TNF IL1B PMC4487054__F1 Signaling of SGK3 and AKT TSC2 BAD SP1 FOXC2 PTEN FLII CXCR4 ID1 PMC5346358__F7 Mechanism of action of BNP inhibitory effect on LPS/ATP-induced IL-1B secretion in human THP-1 monocyte IL16 IL1B PMC8213587__F3 Rethinking the biology of metastatic melanoma: a holistic approach NF1 BRAF NRAS PTEN HIF1A MTOR MYC HEL-S-26 PMC7706714__F3 Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities CDH2 STAT3 MMP14 MMP9 RUNX2 PMC4150779__F7 Functional relevance of rapid transcriptional silencing in activated DCs LTB SYK LTA NLRP3 COX1 BCL10 IRAK1 TRAF6 IRAK4 CARD9 MYD88 PMC8698202__F2 Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms STAT1 STAT2 RNASEL EIF2A JAK1 TYK2 PMC6530577__F3 Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis ANGPTL3 CES1 ATF4 IRS1 PMC3082833__F1 During innate immune activation via LPS-LPB-TLR4, a number of factors of the coagulation pathway are activated, creating the cooperative immuno-coagulative response TF MAP3K7IP1 TLR4 APC TAB3 RELB CD14 RHO TRAF6 SKP2 MYD88 PMC8698202__F1 Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms TBK1 IRF3 IRF7 MYD88 PMC6530577__F1 Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis ATF4 EIF2A XBP1 PMC10137218__F4 WNK kinases regulate HCO3− versus Cl− secretion across human airway epithelia WNK1 WNK2 ASL OSR1 PMC6309157__F2 Molecular pathways that play central roles in mounting an immune response PMC5787570__F6 Inclusion membrane proteins and secreted effectors from C ARF1 SNX6 SNX5 PMC7231511__F1 MHC cross-dressing can promote interaction between helper or regulatory CD4+ T cells and effector T cells TH APC PMC10933445__F6 Model depicting the reciprocal interplay between miR-579-3p and MITF in BRAF-mutant melanoma cells through the modulation of MAPK signaling pathway BRAF ZFR PMC9290522__F3 Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19 MAVS STAT2 IRF3 IRF7 TRAF3 TRAF6 TNF TYK2 IRAK4 MYD88 PMC10452344__F1 Influence of microRNAs on the hippo signaling pathway in gliomas LATS1 NF2 YAP1 PMC11953571__F3 Exercise activates the EGFR/insulin signaling MAPK4 APP HEL-S-11 PMC8058408__F5 Pi3K-Akt and IL-17 signaling pathway (A) PI3K-Akt signaling pathway and (B) IL-17 signaling pathway, with key target genes in the yellow box IDE GAL BAD BCR HEL-S-69p CHL1 PTEN CDT1 MTOR EIF4E PMC7825454__F7 Proposed signaling pathways regulated by HSV-2 infection and TRIM26 activation TBK1 IRF3 PMC8659385__F4 Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses EGF EGFR MTOR PMC8659385__F1 Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses MAX BAD PMC3775863__F3 MicroRNA ‘signature’ during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention RASD1 PIK3CA SOS1 MAP3K12 MTSS1 PPM1E ADPGK LAMC1 XPO6 NCAM1 CCNG1 CTBP2 CDK6 CCND2 ADCY6 ZEB2 CCND1 CAP1 CREB1 DKFZp761E1322 CLIC4 FNDC3A CASP2 ADIPOR2 ANXA2 EXOC5 TWF1 YAP1 PICALM IGF1 BCL2 BDNF CDK9 BCL6 CP PMC7858612__F2 Ferroptosis: mechanisms and links with diseases STEAP3 LPCAT3 FACL4 ADA PMC7858612__F3 Ferroptosis: mechanisms and links with diseases IPP HMGCR GPX4 HEL-S-64p HEL-75 PMC4501067__F9 Biosynthesis pathway of neurotransmitters in insects ACHE TH TRH HDC GLS AANAT ChAT DDC PMC5173258__F1 Ivermectin induces cytostatic autophagy by blocking the PAK1-AKT axis in breast cancer cells PAK1 ATG14 MTOR PMC11383172__F2 IBT induced downstream upregulation of the TNFA pathway in human neutrophils IL15 LTA FAS CSF1 TRADD TNFAIP3 ITCH CXCL5 MLKL CXCL1 SOCS3 CCL5 TRAF3 CCL2 CXCL3 NOD2 IL1B CSF2 CASP8 IL18R1 SELE LIF IRF1 CXCL2 PTGS2 IL6 CXCL10 MAP3K7IP1 CASP3 TRAF1 CASP10 CCL20 TRAF2 FADD PMC4273126__F3 Molecular mechanisms of alcoholic fibrosis SP1 CYP2E1 TAP1 PMC3775578__F1 Novel investigational drugs for basal cell carcinoma SUFU PTCH1 SMO PMC1594921__F6 Immunological regulatory IL-10 and MAP kinase pathways MAPK1 CASP9 JUN JUND ETS2 PTEN ATF2 PTGS2 SOCS3 TRAF6 FOS MAPK14 RB1 CRK EREG RIPK2 MAP2K4 EPOR MOS IL16 SP3 HEL-S-283 ADA PMC9148969__F8 Survival of HT29 Cancer Cells Is Affected by IGF1R Inhibition via Modulation of Self-DNA-Triggered TLR9 Signaling and the Autophagy Response BAX BAD ATG16L1 IGF1 EGFR TLR9 BCL2 IGF1R PMC1594921__F5 Presymptomatic and symptomatic infections including the inflammatory cytokines TNFA, IFNG, and ILB HPSE FAS IFITM2 LCP2 CD14 TNF IFNG ICOS FTH1 CD74 CDA HIPK2 C2 RELA IL18 TAP2 REL PSME2 CYBB PMC8147802__F2 Pluripotency and Growth Factors in Early Embryonic Development of Mammals: A Comparative Approach BAX IGF1 BCL2 CXCR4 BAK1 IGF2 PMC8016624__F4 miRNAs involved in the autophagy pathways MLST8 ATG12 ELF2 MTOR EIF2A PMC7761462__F1 Angiogenesis-related functions of the Wnt/Beta-catenin signaling pathway in colorectal cancer (CRC) APC LRP5 HIF1A CTNNB1 PMC5679442__F1 Stromal niche for epithelial stem cells: a template for regeneration and a brake on malignancy FGF7 HGF IGF1 BMP4 SHH BMP7 GHR PMC8016624__F1 MicroRNAs (miRs) that regulate the apoptotic signaling pathways APAF1 DIABLO FADD PMC3051378__F5 Resulting endoplasmic reticulum (ER) stress and unfolded protein response (UPR) gene network from a modelling approach using the set of differentially regulated genes common to all pancreatic cancer cell lines after nemorosone treatment HEL-S-22 JUN EGR1 MCL1 HEL-S-89n BCL2L11 HMOX1 GPX2 BTG2 FOSL1 CDKN1B CASP3 ASNS BAK1 CCND1 CDK4 PMC9271835__F1 Thiol Modifications in the Extracellular Space—Key Proteins in Inflammation and Viral Infection HMGB1 PRX TRAF6 HEL-S-64p MYD88 PMC4231685__F9 Metabolic and transcriptional profiles for components of the TCA cycle (A) and BCAA biosynthetic pathway (B) HEL60 ACO2 HEL-S-32 MDH2 HEL-S-26 PMC8354730__F2 Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders AQP4 HEL-S-62p TLR4 APOE GSK3B CS TNF PMC4127235__F2 Beta-Catenin is an antagonist of the NFKB pathway LRP5 LRP6 CTNNB1 PMC11856472__F3 Crosstalk between Wnt, Notch, TGFB, BMP, and Hedgehog signaling pathways PRICKLE2 SMAD1 DKFZp781O1323 SMAD2 APC GSK3B SMAD4 ARHA MYC RAC1 CTNNB1 VANGL1 PTCH1 SMO HES1 PMC10537413__F4 Unraveling MYC’s Role in Orchestrating Tumor Intrinsic and Tumor Microenvironment Interactions Driving Tumorigenesis and Drug Resistance MAX BRD4 USP28 USP36 CDK7 MTOR MYC PLK1 CDK9 PMC11707140__F5 Dysregulated expression of genes associated with neurovascular coupling PLD2 PTGS1 ARHA PTGS2 KCNJ2 PMC4127235__F1 Wnt/Beta-catenin pathway APC LRP5 LRP6 CTNNB1 PMC2778230__F3 Apoptotic signaling in aging muscles BAX TRADD ID2 APAF1 FADD PMC7564842__F2 Signaling crosstalk between the KRAS and NFKB pathways TBK1 RALB KRAS IRAK4 IL1B MYD88 PMC5679229__F3 Nitric oxide - the forgotten child of tumor metabolism GLS FASN HEL-S-30 PMC11117676__F2 The nuclear signaling pathway of RIP-mediated EpCAM EPCAM BACE1 FHL2 LEF1 PMC8213731__F8 Inhibition of discoidin domain receptors by imatinib prevented pancreatic fibrosis demonstrated in experimental chronic pancreatitis model DDR1 SMAD2 SMAD4 DDR2 PMC9403516__F8 Astragaloside IV promotes pharmacological effect of Descurainia sophia seeds on isoproterenol-induced cardiomyopathy in rats by synergistically modulating the myosin motor TPM1 HEL-S-273 NPPA PMC9685729__F2 Noonan syndrome: improving recognition and diagnosis CBL SPRED1 NF1 SHOC2 RIT1 PTPN11 GRB2 PMC9935929__F5 Signaling pathways in rheumatoid arthritis: implications for targeted therapy SYK BTK GSK3B NAV2 HIF1A ATF2 MTOR RAC1 CTNNB1 PMC5454641__F1 mTOR Signaling Pathway RHEB TSC2 TSC1 PMC5347766__F9 PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway RPE RPL11 ATM MDM2 PMC4859092__F1 Workflow of the PSF-SOM method as applied to lung diseases HP UNK PMC7974515__F7 Graphic summary of this study TIEG2 TGFB1 TGFBR1 PMC4859092__F8 Community detection in the lung disease graph HP PMC2773833__F3 Drivers of senescence and therapeutic opportunities in WS and HGPs TF BAX ATR ATM PMC4602270__F6 Label-free Quantitative Analysis of Changes in Broiler Liver Proteins under Heat Stress using SWATH-MS Technology GFER SPINK5 CNP CTSG ABCA1 AHSG POSTN HEL-S-125m FBLN5 PLCG2 HPGD SLC16A2 HEL117 HEL-S-61p HSD17B7 CYBB PMC6527386__F1 Molecular factors involved in cell migration CDC42 SUN1 RAC1 PMC7597513__F2 This is a simplified version of the canonical nuclear factor kappa B cell (NFKB) pathway that is negatively regulated by A20 binding inhibitor of NFKB (ABIN1) function IRAK1 TRAF6 IRAK4 MYD88 PMC3743959__F1 Toll-Like Receptor (TLR)-Associated Sequence Variants and Prostate Cancer Risk among Men of African Descent LPA BTK TIRAP NFKB1 IRAK3 CASP3 CD14 IRAK2 TRAF6 TNF IRAK4 MYD88 PMC4596921__F1 mtROS in bacterially triggered immune responses ECSIT STAT1 PGAM5 MLKL TRAF6 TNF HEL-S-44 PMC6013556__F1 Pathway activation after damage-associated molecular patterns (DAMPs) stimulation HMGB1 TLR4 CD14 IRAK1 IRAK4 MYD88 PMC3914352__F10 Flow diagram representing the molecular interactions in the Toll-like receptor signaling pathway (from KEGG database) TIRAP TLR3 PDC TLR9 TLR8 CD14 TLR7 TRAF6 RAC1 MYD88 PMC4115628__F2 Sphingolipid metabolism SMS tmp_locus_29 PC CS PMC12210125__F3 Tumor cell-macrophage interactions reprogram M2 TAM polarization STAT3 SYK IGF2BP3 CCR5 LIF MISP HIF1A CCL5 CCL2 CXCL8 RAC1 CXCR1 ALK COX2 ETV4 YTHDF2 TDG PMC4424324__F7 Integrin-mediated signaling pathway that regulates actin polymerization, actin cytoskeleton remodeling, and microcluster formation CDC42 HEL-S-28 PMC12210125__F2 Signaling pathways for the polarization of TAMs towards the M1 phenotype SYK DLL4 BATF2 YTHDF2 IFI16 IRF4 PMC5133779__F4 Differentially expressed proteins involved in HIF-1 signal pathway TF FH HEL-S-133P EPO IL6 VHL PCK2 HMOX1 TFRC ENO3 HEL-S-68p TLR4 HEL-S-87p HEL-S-26 PMC8616465__F1 Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas RAD52 RAD51 AHR SSB PMC7427779__F8 Schematic summary of this study ELF1 RAC1 PMC6121518__F1 Crosstalk between Hh signaling and autophagy based on current evidence VMP1 GSK3B DHH BNIP3 IHH MTOR KRAS ALOX5 ALOX15 SHH SMO EIF2A GLI3 PMC11901361__F2 Proposed FRAlpha-mediated endocytosis and signaling pathways in cells STAT3 PMC6563035__F1 PD-L1 reverse signaling in tumor cells and macrophages IFNG CD80 PMC10357943__F3 Shining a light on the dark proteome: Non‐canonical open reading frames and their encoded miniproteins as a new frontier in cancer biology CIP2A STAT3 USP28 FBXW7 EGFR AKT3 SMIM30 SRC PMC10757071__F5 Significance of long non-coding RNAs in the pathogenesis, diagnosis and treatment of inflammatory bowel disease TNFRSF1B TGFB1 HEL-S-133P TLR4 EZH2 PMC2586335__F1 Ras signalling pathways JUN BAD CCND1 PMC12052831__F1 FAS mediates apoptosis, inflammation, and treatment of pathogen infection BAX FAS FADD PMC4708176__F2 ERK and non-ERK mediated non-genomic AR signaling TF RAF1 SHBG FOXO1 MTOR SRC PMC7794986__F2 Molecular basis of chemoresistance in GBM SP1 E2F7 MGMT PMC11333789__F6 Effect of rotenone on regulating the Nrf2 signaling pathway and induction of Parkinson’s disease was proposed FES BDNF PMC12052831__F2 FAS mediates apoptosis, inflammation, and treatment of pathogen infection STAT3 EGF FAS MAP3K7IP1 NOX3 TAB3 RIPK1 SRC FADD PMC11044150__F10 Modulating the MAPK signaling pathway of LQZ against AD MAX EGF MAP3K7IP1 GRB2 TRAF6 TNF MYD88 PMC7956987__F1 IL-18 signaling pathway TRAF6 IL18BP MYD88 PMC11972507__F6 ceRNA Network of m6A-modified circRNAs in OSA-induced Cardiac Injury COPS7A RFX2 BACE1 ST6GALNAC6 DECR1 ERMAP HECTD4 CARM1 DOLPP1 VAMP1 SUSD6 SENP2 PLD4 ARFGAP2 FBXO27 BICDL1 TMED4 SLC35E1 CDPF1 C7orf24 HACD2 HHIPL2 PAQR4 FOSL1 VIPR2 ARHGEF7 KLC2 FADD HEL-S-1a CLIP2 PMC10869798__F2 Microglial activation and neurodegeneration TREM2 SYK TNF IL1B PMC7784643__F1 Canonical and non-canonical signaling pathways of AhR AHR SRC PMC3632094__F8 The process of LC3-associated phagocytosis (LAP) RIPK3 ATG5 PMC4468438__F1 Major pathways for the metabolism of IFO CYP2B6 CYP2C19 CYP2C9 CYP3A4 PMC9317256__F1 Biosynthesis of Non-Endogenous Apocarotenoids in Transgenic Nicotiana glauca HEL-S-62p C2 PMC8834185__F2 Cytoskeletal Remodelling as an Achilles’ Heel for Therapy Resistance in Melanoma PAK1 PMC9022980__F1 TNF-induced necroptosis occurs when upstream pro-survival and pro-apoptotic pathways are inhibited RIPK3 TRADD C2 RIPK1 TNF TRAF2 FADD PMC3637854__F2 Overview of UPR signaling ATF4 EIF2A XBP1 PMC2582196__F2 Classic renin-angiotensin-aldosterone system (RAAS) pathway and angiotensin II (Ang II)/insulin signaling in the vascular smooth muscle cell IGF1 IRS1 PMC4651655__F1 Mevalonate pathway, NHRs and immunity NR1i1 PGR EBP SQLE DHCR24 MVK RORA LBR HMGCS1 ACAT1 HMGCR PMVK MVD DHCR7 FDPS FDFT1 PMC3665263__F2 Innate immune system in pneumococcal meningitis infection NLRP3 TLR4 TLR9 AIM2 TRAF6 IRAK4 MYD88 PMC2702319__F4 Distributions of the orthologous gene groups containing duplicate genes that arose through 3R-WGD (shown as gray boxes) in the network diagrams ACLY FH OGDH CLYBL DLD CAMK4 CS PMC6158718__F1 PI3K/AKT pathway RHEB TSC2 BAD TSC1 PTEN MDM2 MYC IRS1 PMC7052015__F1 Detailed illustration of the experiment KEAP1 MAF PMC6158718__F2 PI3K/AKT pathway in muscle tissue when normal state and insulin resistance EEF2K TG EIF4B EIF4E PMC7843693__F4 Therapeutic potential of mesenchymal stem cells in treating both types of diabetes mellitus and associated diseases MSC TNF IRS1 PMC5660598__F4 Dexamethasone (Dex) and monphosphoryl lipid A (MPLA) treatment leads to changes in the expression of genes involved in biological processes associated with immune response regulation CCL18 CXCL5 S100A8 CCL5 MYC TNFRSF6B NCF1 ALOX15B ISG20 ADIP CD24 HEL-S-171mP ALOX15 ISG15 FCGR2A THBS1 ETS2 FCER1A CD14 ATP1B1 IL7R MT2A MRC1 FPR1 AIF1 PLTP GPR183 S100A9 PMC11214942__F5 Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions CRK PIEZO1 ARHA SRC RAC1 PMC11214942__F4 Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions BAX BAD PMC10970410__F12 LncRNAs potentially involved in the immaturity-stemness regulation processes in the human keratinocyte lineage WNT5B BAMBI KLF4 FGF7 GDNF SMAD6 BDNF REL PMC10971967__F6 Proteomics analysis of gastrocnemius and soleus muscle in the ET group EHD2 MAPK1 MUSTN1 TUBB4B HK2 PCCA PCCB SIRT2 PDK2 TUBB NDUFAB1 NDUFB10 ENG PDHA1 DLAT COL1A1 HEL-S-68p COL4A2 CASQ1 MDH2 LAMA4 APIP PMC6406375__F1 Major calcium channels, pumps, exchangers and sensors in mammalian cells CAD ORAI1 STIM1 MCU HEL-S-11 PMC7459397__F1 FGF18‐induced ER‐phagy in chondrocytes FGFR4 TFEB FGFR3 FGF18 IRS1 PMC4344885__F6 Endocardial Fibroelastosis is Caused by Aberrant Endothelial to Mesenchymal Transition EGF SMAD1 DKFZp781O1323 SMAD2 BMP7 PMC3426835__F5 Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis CDK5 APOE APP PMC6160488__F4 Crosstalk between the interferon signaling pathway and PD-L1 signalosome STAT3 CASP9 ATR PDS5B STAT2 VAC14 TTI1 STAT1 NF1 IFNAR1 CASP3 ATM JAK1 PMC10838202__F5 mRNA-seq results of KEGG pathway enrichment analysis and western blot results MAFK NGF TIRAP tmp_locus_29 APP TNF PMC3961774__F5 Role of Heme Oxygenase-1 in Postnatal Differentiation of Stem Cells: A Possible Cross-Talk with MicroRNAs SOX9 BMP2 MSC NFATC1 ATF4 RUNX2 CTNNB1 PMC3179275__F4A Integrative computational biology for cancer research MAX JUN CRKL PMC6197618__F6 RHBDF1-facilitated membrane trafficking of pro-TGFA via CCV pathway TGFA ADAM17 EGFR RHBDF1 AP1B1 PMC5341867__F2 TP53 mutation hits energy metabolism and increases glycolysis in breast cancer HEL107 G6PC2 ENO2 HEL-S-278 G6PC3 G6PC1 ENO3 RPIA FBP2 HEL-S-20 HEL-S-68p PFKP HEL-S-162eP FBP1 ENO1 PFKL GLS2 PFKM PMC8176240__F6 Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression STAT3 BAX CASP9 BAD RAD51 POLK BRCA2 SMAD4 PMC4128997__F3 PPAR signaling pathway UBC UCP1 HEL-S-28 PLTP PMC4128997__F2 Antigen processing and presentation pathway IFNG HEL-S-99n TAPBP CANX MHC2TA B2M PMC3256879__F8 A hypothetical diagram of the involvement of ATF6 in BMP2-induced osteoblast differentiation BMP2 RUNX2 PMC5650102__F2 T Cell Signaling and Gene Regulation Defects in Systemic Lupus Erythematosus (SLE) CD44 STAT3 ICOS IRF4 MTOR BCL6 PMC2846061__F3 Ovary: basic biology and clinical implications BMP15 TNFAIP6 PTX3 SMAD1 EGR1 EDN2 PGR EGFR CTSL PTGS2 AREG RUNX2 FSHR EREG SFRP4 RUNX1 INHA CCND2 NR3A2 BTC HAS2 SNAP25 SRC PMC9409119__F2 Emerging Key Role of the mGluR1-PKCG Signaling Pathway in the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental Viewpoint INPP5A STK17B RGS8 PMC11284857__F3 Disturbance of DFC signaling pathways results in disorders of osteoclast differentiation TGFBR2 TLL1 MSX2 PMC9409119__F1 Emerging Key Role of the mGluR1-PKCG Signaling Pathway in the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental Viewpoint INPP5A STK17B RGS8 TBP TRPC3 PMC10982379__F2 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer BAX BCL2 PTEN MTOR PMC10982379__F1 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer TF GLS STEAP3 GPX4 LPCAT3 FACL4 ALOX15 HEL-S-64p PMC10982379__F4 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer STAT3 TIMP1 GPX4 HEL-S-29 MGST1 SLC7A11 ABCC5 ARG2 PMC10982379__F3 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer GPX4 PTEN SLC7A11 PMC8298031__F2 In vitro Assays and Imaging Methods for Drug Discovery for Cardiac Fibrosis TGFB1 ARHA CTGF PMC10982379__F6 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer IFNG FTH1 PGAM1 CERK GPX4 SLC7A11 ABCC5 LCN2 PMC3121540__F4 A gene network shows that mRNA levels of PDGFR and ECM-related genes are significantly correlated in human breast cancer FBN1 LOX MFAP2 SPARC MMP2 DCN PMC10982379__F5 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer TF SIRT3 STEAP3 LPCAT3 FACL4 PMC9657596__F6 Lactucin, a Bitter Sesquiterpene from Cichorium intybus, Inhibits Cancer Cell Proliferation by Downregulating the MAPK and Central Carbon Metabolism Pathway HEL-S-133P HEL-S-30 CCND1 PMC10845554__F1 IL-17-producing Treg differentiation STAT3 DDX5 APC IKZF4 SMAD4 CTLA4 SKI ITGAV HEL-S-92n ICOS RORC TLR4 CCR6 MAF CCR7 AHR IL2 IKZF2 FOXP3 PMC8833974__F5 KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications GRB2 FOXP3 KRAS PMC4323371__F1 TERRA regulation of telomere length for the protection of chromosome ends involving TRF2 CTCF ATM PMC5316868__F2 Pervasive translational regulation of the cell signalling circuitry underlies mammalian development GPR162 MAP3K10 PIK3CD PIK3R2 MAPK15 PRKCZ NTRK3 MAP9 MAPK6 MAPK4 EPHB2 CA3 MAP6 GPR155 HEL-S-11 MAPK12 GPR180 KDR GPR135 PRKAR1A AXL ROR2 GPR27 GPR63 NTRK2 GPR153 GPR107 GPR157 ACKR5 HRAS ERBB3 EPHB3 GPR85 GPR137 SOS2 PAK1 AATK MAPK7 MAP3K7 MAP2K5 MAPK10 ADCY1 GRB2 RET GPR37 EGFR GPR108 PTEN RYK MAP2 GPR19 PRKCB MERTK PRKCE INSR GPR156 EPHB4 ROR1 GPR50 GPR161 EPHB6 KIT EPHB1 KRAS GPR4 PDGFRA NTRK1 ERBB2 FGFR3 GPR173 MAP2K1 GPR183 PMC6139250__F1 NFKB signal transduction pathway CD40 CXCL1 RELB MMP9 IL1A MYC BCR COX2 RELA MMP2 CDK2 TRAF1 VCAM1 TRAF2 CCND1 PMC9928209__F2 Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug BAX HMGB1 CDK6 CDK2 MTOR CDK4 PMC3970201__F2 Self-consumption: the interplay of autophagy and apoptosis ATG12 MCL1 SRC TNF PMC5316868__F3 Pervasive translational regulation of the cell signalling circuitry underlies mammalian development DVL1 APC IFT172 EVC2 EVC DYNC2H1 PTCH2 SUFU PTCH1 WWC1 SHH DYNC1H1 SMO NF2 HBB PMC5837968__F6 Schematic illustration of SFKs mechanism of action in interferon regulatory factor 1 (IRF-1) K63-Ubiquitination TLR8 IRF1 TLR7 TRAF6 PMC6943360__F1 An overview of MIF signaling pathways: MIFs interactions can contribute to the formation of cancer and neural development CD44 BAX BAD CD74 MIF IL8RB CXCR4 PMC3673040__F1 Leptin is generated in adipose tissue and transported via the bloodstream to the hypothalamus PCSK1 POMC MC4R NPY AgRP BDNF PMC3763758__F1 HIV-related neuropathic pain pathway COX2 BDNF CXCR4 PMC8953969__GA STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS) RIPK3 TBK1 CGAS GSDMD ZBP1 NLRP3 MLKL IFNAR1 CASP3 DDX41 AIM2 RIPK1 PMC7444278__F3 Major components of the vertebrate Hedgehog pathway are dynamically localized to the primary cilium in response to Hedgehog ligand GPR161 KIF7 SUFU PTCH1 SMO PMC2902748__F1 Hsp90-dependent modulation of proangiogenic signaling pathways in cancer EGF HGF EPHA2 EGFR MTOR SKI PMC10525272__F6 Platelet activation pathway confirmed in the KEGG pathway analysis SNAP23 VWF SYK COMP VASP FYN F2 FRK LYN ARHA PROC DAO PMC10525272__F5 Canine Somatic Mutations from Whole-Exome Sequencing of B-Cell Lymphomas in Six Canine Breeds—A Preliminary Study TRDN PLN CAV3 CAV2 HRC BCR PI3 MCU PMC10525272__F4 Vascular smooth muscle contraction pathway confirmed in the KEGG pathway analysis CAD ADM EDNRA CNP ARHA PTGIR AVP PMC9371824__F12 Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury TLR4 MAL CD14 TRAF6 LBP IRAK4 PMC8062757__F1 Schematic diagram showing FST modulation of TGFB/Samd 3 signaling pathway during adipose browning GDF11 FST MYF5 PMC8418449__F4 Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease HEL107 HEL-S-133P LAT LDHB TIGAR ARHA ME1 HMGCR PHGDH F2 HEL-S-162eP AASDH HEL-S-26 HEL-S-64p PMC10946270__F3 Classical and alternative pathways of NF-KB signalling are mediated by a variety of receptors and signalling molecules, including TLR, CD30L, CD40L, RANKL, etc BCL10 CARD11 RELB IRAK1 TRAF6 IRAK4 MYD88 PMC7064735__F3 Molecular mechanisms underlying PM2.5-induced defective airway epithelial host defense functions ASL EGFR PMC3164721__F1 Phospholipase C Isozymes Are Deregulated in Colorectal Cancer – Insights Gained from Gene Set Enrichment Analysis of the Transcriptome BAX PIK3CA FOXN1 APC BRAF PTEN RHO GRB2 KRAS PMC9172986__F6 An approach to cellular tropism of SARS-CoV-2 through protein–protein interaction and enrichment analysis UTP15 VWF POLL UTP4 IMP3 NMD3 IMP4 NHP2 PWP2 NOB1 POLI NHP2L1 F2 NOP56 F9 PMC9172986__F5 An approach to cellular tropism of SARS-CoV-2 through protein–protein interaction and enrichment analysis NAPA POR HEL-S-92n MRPS16 SP1 MOS SP4 PMC5067532__F3 Hydrogen sulfide in DN MTOR NOX4 PMC5389977__F3 Release of growth hormone (GH), Wnt, or RANKL, as stimulated by progesterone (P4), promotes interaction with various signal transduction pathways TF EGF EGFR PTEN MTOR GHR LEF1 CTNNB1 PMC5335555__F6 CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGFB signaling PRDM14 PRDM1 SMAD2 SOX2 SRC PMC5389977__F4 Interaction of HER-activated pathways with canonical Wnt signaling TF EGF HGF APC GSK3B MUC1 PTEN SRC CTNNB1 PMC4814376__F1 Summary of metabolic FGFs FGF8A FGF21 FGFR4 FGFR1 PMC9676213__F7 MS-proteomics provides insight into the host responses towards alginate microspheres CRP CFD CFH PLG VTN C4A MASP1 HEL-S-92n CFI TFPI C2 CLU PROC PMC9685611__F2 Ovarian cancer stem cells: Critical roles in anti-tumor immunity CD44 COX1 CTLA4 MYD88 PMC4176146__F1 The hexosamine biosynthetic pathway and O-GlcNAcylation are shown OGA OGT COCH PMC7434989__F2 Emerging roles for the IL-6 family of cytokines in pancreatic cancer STAT3 SOCS3 GRB2 JAK1 PMC7264916__F1 Mutations and signaling pathways in vascular anomalies EPHB4 BMP10 PIK3CA ENG SMAD1 DKFZp781O1323 PDCD10 PTEN MAP2K1 MTOR PMC8508931__F5 Comparative Phosphoproteomic Analysis Reveals the Response of Starch Metabolism to High-Temperature Stress in Rice Endosperm AGPS GPT PMC4331812__F5 Metabolic flux map of central carbon metabolism in cotyledons at early seed fill HEL107 GNE MAL PAH PMC3513650__F1 BRCA and RAD52 pathways of DNA double-strand break (DSB) repair RAD52 RAD50 RAD51 MRE11A BRCA2 PALB2 PMC8418449__F6 Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease HMGCR F2 HEL-S-162eP DHFR ARHA PMC6600513__F1A Signal Exchange through Extracellular Vesicles in Neuromuscular Junction Establishment and Maintenance: From Physiology to Pathology MUSK LRP4 F2 APC PMC8071006__F6 Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model CTRL LAT2 SPACIA1 PMC3603147__F7 Inhibition of Na+-K+-2Cl− cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells OSR1 CIT PMC4833964__F1 Cancer-relevant pathway map MTOR CTNNB1 PMC5406580__F2 Hypothalamic circuits regulating thermogenesis of BAT and browning of WAT LEPR POMC MC4R NPY ARC AgRP MPO PMC2922475__F1 CD73: A novel target for cancer immunotherapy ADA PMC6387609__F7 Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3B/Beta-catenin signal pathway GSK3B CTNNB1 PMC5857625__F7 Schematic representation of murine and human gonadal androgen synthesis POR STAR HSD17B6 CYP17A1 CYP11A1 PMC8056114__F1 NGF-mediated regulation of the NGFR and NTRK1 signaling pathways NGF NGFR NTRK1 CR2 LINGO1 RHO CR1 PMC8805653__F1 IL-33/ST2 pathway and its conceptual role following ischemic stroke TLR4 IL33 IRAK1 TRAF6 IRAK4 MYD88 PMC5031419__F4 Non-overlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi RB1 BAD BRAF KIT PTEN MDM2 SRC CDK4 PMC6770591__F7 Scheme of the de novo synthesis pathway of glutathione CTH HEL-S-64p PMC6362810__F3 Multiple nonunidirectional levels through which autophagy-related processes in senescence affect regulation of SASP genes, often via NFkB activation IL10 TRAF3IP2 IL1A MTOR GATA4 PMC3873730__F3 Transcriptome Analysis of Human Injured Meniscus Reveals a Distinct Phenotype of Meniscus Degeneration with Aging CLEC3A CDC20 UBE2C PCNA CKS2 PLK4 LIPA CKAP2 NGF TACC3 SOX9 PRC1 TTK POMC RPL14 HEL-S-66 GGH NOTCH1 UBB CDCA2 MMP7 POLE2 LYL1 GDNF ID2 E2F2 ARHGAP15 MAL FZD9 COL11A2 FGF2 DBNDD1 S100A1 c-fgr FGL2 FGFR3 CEP55 COL9A2 ACTG2 ABTB2 FGF18 SKA3 PMC7072559__F2 Metabolic pathways contributing to glutamine addiction in gliomas PC MTOR HEL-S-26 GPT PMC9511797__F2 Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer PTEN PMC9511797__F1 Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer SGK1 TRPC6 S100P PMC9313971__F1 Xeroderma Pigmentosum: A Genetic Condition Skin Cancer Correlated—A Systematic Review XPA PCNA XPC PMC9928209__F7 Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug EIF4B GAL PTEN MTOR EIF4E PMC6280650__F1 Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches TBK1 CGAS CDA IRF3 PMC7701511__F3 VEGFA/VEGFR2 system differentially modulates the UPR activation in condition of transient or sustained ER stress VEGFA EIF2A PMC2672430__F2 Prodeath or Prosurvival: Two Facets of Hypoxia Inducible Factor-1 in Perinatal Brain Injury COX2 EPO BNIP3 IGF2 VHL PMC8127222__F1 Emerging role of the KCTD proteins in cancer HDAC1 KCTD15 SHH SMO PMC8127222__F2 Emerging role of the KCTD proteins in cancer TNFAIP1 BTBD10 APC GSK3B KCTD1 KCTD20 KCTD12 KCTD10 NOTCH1 CTNNB1 PMC3046427__F2 Beta-Catenin is at the hub of multiple signaling pathways SOX17 SIAH1 EGFR PYGO2 APC GSK3B LRP5 HEL-S-28 LRP6 EZH2 PIN1 CTNNB1 FER ERBB2 SKP1 NLK SRC CCND1 PMC9619051__F1 Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling SOCS1 IL-21 STAT3 OSM EGFR LIF IL27 EPO IL2 STAT4 HIF1A TNF PMC7799431__F1 Importance of Keeping Time in the Liver NAMPT SIRT1 SIRT6 RORA PMC2903563__F7 Glucose metabolic pathway response POC5 GPD2 ENO2 HEL-S-68p GAD1 ENO1 PMC11284857__F4 Depicted regions primarily reside within the dental follicle tissue surrounding the root apex WNT10B TGFBR2 PTCH1 SMAD4 PMC7012465__F2 Regulation of hepcidin expression (adapted from Silvestri et al.) TF STAT3 SMAD1 TFR2 DKFZp781O1323 SMAD4 IL6 IL6R HFE2 ERFE BMP6 TLR4 BMP2 HFE TMPRSS6 PMC3871684__F1 Microfluidic Generated EGF-Gradients Induce Chemokinesis of Transplantable Retinal Progenitor Cells via the JAK/STAT and PI3Kinase Signaling Pathways STAT3 EGF JUN RAF1 SHC1 EGFR CR2 MTOR FOS PLCG1 MAP2K4 MAP3K1 RPS6KB1 PRKCA MAP2K1 JAK1 SRC PMC6098640__F5 The pathway through which IL-33 stimulates the proliferation signaling of CRC cells COX2 IL33 PMC4730337__F1 EGFR transactivation by GPCR HBEGF EGFR GRB2 SRC PMC7238533__F2 Role of Fbln7 and its C-terminal fragment in the modulation of cellular functions under physiological and pathological conditions STAT3 FBLN7 STAT1 ARHA RAC1 PMC7178193__F2 Adiponectin properties on healthy skeletal muscle TF NR1C1 APPL1 ADIPOR1 IRS1 PMC4900151__F1 The role of REDD1 in the regulating muscle protein balance in response to acute alcohol RHEB RPS6 TSC2 TSC1 ULK1 PMC4261235__F1 Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway PI3 PIR PTEN IRS1 PMC5542187__F5 Simplified diagrams of putative signaling pathways responsible for the different migration patterns (i.e CDC42 ARHA MDM2 MTOR PMC6315991__F1 Links between Lipid and Iron Metabolic Pathways ACLY EBP SC5D HAMP PCBP1 ACACA RP1 GPAM LOX HMGCR STEAP3 HEPH HEL-S-5 FES TM7SF2 PMC3476325__F9 Proposed model for how CCL2 signaling through CCR2 signaling regulates survival and motility of breast cancer cells CCR2 ARHA CCL2 PMC4114208__F1 Unfolded protein response pathways are shown ATF4 XBP1 PMC11659389__F5 STRING protein‒protein interactions between the recognized proteins and our prioritized proteins for each skin cancer SLC45A2 KRT1 CSA2 ROS1 MC1R ASIP LTBR MTAP KRT14 BRAF CTSS TERT CDKN2A KRTAP10-9 CLPTM1L SYP SUFU TCHH SHH NRAS SMO TLR7 PMC8236816__F2 Targeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal Models RAB10 VPS35 LRRK2 PMC8236816__F1 Targeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal Models VPS35 HEL-S-130P LRRK2 ATG9A RAB7L1 PMC2786705__F8 Continued defect in IRF-3-deficient BMDCs STAT1 STAT2 IRF3 PMC6381377__F6 Deregulated Wnt signaling pathways in the BM of ENU induced experimental leukemic mice CDH2 WNT3A DKK1 ROR2 CCND1 CTNNB1 PMC4227184__F10 Pathway analysis HRAS JUN PAK1 PDPK1 EGFR VAV1 CS VCAM1 VEGFA RAC1 PMC11064393__F1 CGAS-STING signaling pathway TBK1 CGAS IRF3 PMC6757413__F4 Important signaling pathways that govern the differentiation of pancreatic conversion and the mechanism of action of different small molecules and peptides reported on pancreatic differentiation from MSC EGF HGF EGFR APC APP NODAL MTOR CTNNB1 PMC10389822__F2 Intersection of COVID-19 and Rheumatoid Arthritis: Shared Mechanisms, Treatment Challenges, and Potential Therapeutic Approaches STAT3 BRD4 RELA PMC8284093__F11 Genomic Response to TGFB1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney TNFRSF10B PMS2 EDN2 MCL1 TAP1 BBC3 PMAIP1 PIDD1 RB1 PPM1J E2F3 MMP2 RRM2B APAF1 HTT NR1i1 SP1 TFDP1 APC JMY CCNI BNIP3L TNFRSF10D DDB2 TSC2 COL18A1 TP63 BCL2 PRKAB1 SESN1 BAK1 CASP10 DUSP5 HEL-S-103 TGFA TP53BP2 PCNA BCL2A1 TIGAR TNFRSF10A GPX1 CASP6 AFP POU4F1 CEBPZ TADA2B FOXA1 HIC1 POU4F2 TYRP1 ARID3A NFYB SPP1 PCBP4 PLK3 BCL2L14 SCN3B NFYA CREBBP EP300 BCL6 KAT2A RCHY1 PRMT1 EPHA2 RGCC BCL2L2 DKK1 MDM2 HDAC2 SMARCA4 MSH2 TP53INP1 AIFM2 PRDM1 PERP TAF9 ATF3 BTG2 NFYC TP73 HEL-S-31 FDXR TRIAP1 RNF144B FAS HGF DDIT4 EGFR CD82 PML SFN PTEN TRRAP SH2D1A CCNB1 ZNF385A BAX DDX5 JUN E2F2 LIF DROSHA CCNC DGCR8 HEL-S-130P PMC3787304__F1 Different phosphorylation sites on STAT3 mediate canonical and non-canonical functions of the Notch signaling pathway STAT3 GFAP HES3 HES1 HES5 PMC8284093__F10 Genomic Response to TGFB1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney RFWD2 BAX CASP9 ATR CD2 AIFM2 PERP PTEN MYC TSC2 SIVA1 CASP3 CDK2 ATM PIGS MDM2 PMC6895278__F4 Models for REV3-dependent synthesis at difficult-to-replicate regions in the genome RAD52 RAD51 PCNA PMC8006921__F7 Wnt signaling gene expression profiling in healthy versus asthmatic bronchial fibroblasts generated by PathViso pathway analysis and drawing software POR NFATC2 ARHA INS PSCA FOS PMC11855906__F4 Mechanistic insights and multifaceted applications of autophagy as a potential therapeutic target for metabolic cardiomyopathies STAT3 ALDH2 FTH1 METRNL PINK1 RTN3 ULK1 EIF5A NAMPT BCL2 RIPK1 SEC62 PMC11855906__F3 Simplified scheme for the regulation of cardiac selective autophagy in HFD-induced metabolic cardiomyopathy STAT3 BRD4 RTN3 ULK1 TFEB PLG SEC62 PMC6759601__F5 Schematic overview of gene expression regulation of fatty acid oxidation and tricarboxylic acid (TCA) cycle in tPVAT and IAT EHHADH IDH3B LAT SLC25A20 CS ACADM SDHAF1 SUCLG1 SUCLA2 ACADVL HEL-S-32 MDH2 PECR FH ACADS SDHAF2 MDH1B SDHD SDHA SDHB TG OGDH SUCLG2 DLD ACADL SDHC PMC11855906__F2 Comprehensive scheme for the complex regulation of cardiac non-selective autophagy in STZ-induced metabolic cardiomyopathy LAMP2 METRNL FOXO1 ULK1 BCL2 RIPK1 MTOR NRG4 PMC6830338__F1 Transcription regulators (TRs) that modulate glycolytic metabolism in cancer cells PARP14 HEL-S-162eP PTEN TIGAR MTOR PMC11855906__F1 Comprehensive scheme for the complex regulation of cardiac non-selective autophagy in HFD-induced metabolic cardiomyopathy ALDH2 ATG12 ULK1 BCL2 MTOR ATG5 PMC7714584__F6 Target-pathway network CXCL11 HSD3B2 MMP3 PTGS2 MMP9 ABCG2 CXCL10 IL1B SPP1 PMC8863938__F2 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers BAX BAD MEI1 PMC6707069__F8 Influence of extracellular HA in erlotinib efficacy using a reductionist 3D glioblastoma model CD44 STAT3 EGFR PTEN PMC5387055__F3 Upon antigen encounter T cells differentiate into effector cells PLCG1 HIF1A CTLA4 MTOR MYC PMC8863938__F4 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers BAX BCL2 MTOR PMC8863938__F3 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers BAX BCL2 ATF4 EIF2A PMC8863938__F5 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers BAX CSA2 PMC7267729__F5 Dysregulation of the Myostatin Pathway in Mtm1−/y MiceThe members of the myostatin pathway analyzed in this manuscript at the mRNA or protein levels are indicated in this figure GDF8 GDF11 SMAD2 PMC1435694__F1 Chemistry of the retinoid cycle reactions in the vertebrate retina RPE RPE65 RGR PMC8063466__F4 Quercetin inhibits overactivation of dormant PMFs induced by Cy RPS6 AMH MTOR PMC9252958__F1 Contribution of specific ceramides to obesity-associated metabolic diseases CERS3 CERS5 ACSL5 SMS SGPL1 CERS1 CERS2 KDSR CERS6 UGT8 tmp_locus_29 DGAT2 SGPP1 HEL-S-5 CER1 PMC5403850__F1 Pathological effects of chronic oxidative stress TH CD36 IRS1 PMC5502164__F1 Methylation cycle pathway: (A) Methionine and homocysteine (Hcys) are generated by the following enzymes: CBS = cystathionine Beta-synthase, MAT = methionine adenosyltransferase, MS = methionine synthase, SAHH = S-adenosylhomocysteine hydrolasa VIT HEL-S-20 PMC9586738__F1 Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine ALDOB HEL-S-133P F2 HEL-S-162eP LDHB MTOR HEL-S-87p KRAS PMC7795614__F3A Comparative Proteomics Analysis Reveals Unique Early Signaling Response of Saccharomyces cerevisiae to Oxidants with Different Mechanism of Action RCC1 RAN PMC9687454__F2 Tirzepatide—Friend or Foe in Diabetic Cancer Patients? IGF1 IGF1R MTOR GIPR PMC5477726__F1 BMP4 signaling pathways BMPR2 SMAD1 DKFZp781O1323 BMPR1A BMP4 NOG SMAD6 SMAD4 PMC3968382__F1 New anti-complement drugs: not so far away CD59 HEL-S-62p PMC12112211__F6 Activation of T cells by dendritic cells in lymph nodes; (B) binding of T cells to tumor cells inducing apoptosis; (C) signaling pathways for activation of cell growth and proliferation or signaling pathways for cycle arrest or apoptosis CD80 CASP9 FAS CASP8 CASP2 APC PTEN TNF STAT1 TSC2 TSC1 MDM2 FADD PMC5095497__F7 Role of the citrate pathway in Down syndrome (DS) ACLY CIC SLC25A20 PMC3195227__F1 A schematic diagram of the kynurenine pathway HEL-S-90n KYNU KMO PMC8959454__F1 Drug Discovery of DKK1 Inhibitors CKAP4 JUN DKK1 APC ATF2 ARHA CTNNB1 PMC3342334__F9 Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway RHEB TSC2 TSC1 ARC EIF4E PMC4138453__F3 Metabolic pathway of arachidonic acid via 5- lipoxygenase LTB LTA GHB3 PMC3357406__F3 Divergent Genomic and Epigenomic Landscapes of Lung Cancer Subtypes Underscore the Selection of Different Oncogenic Pathways during Tumor Development BRIP1 BRD4 TGFB1 MPHOSPH9 SMAD2 SH3RF1 LSG1 SNX5 CDC42EP3 BLM MAPK14 SLC25A4 PNKD SIAH2 TNFRSF13C ATP13A3 APEH KPNA4 JAG2 UMPS CNBP KPNA1 ECSIT MSH6 PITPNB LGALS7B BAG4 IGSF8 NR2A1 DAPK2 STAT4 ASF1B PMC7827855__F1 Interplay between the Hippo, Wnt and ARF/p53 signaling pathways in development and tumorigenesis LATS1 FOXM1 LATS2 APC ATM MDM2 PMC3410580__F6 p62/SQSTM1 acts either as a pro-oncogene or as a tumor suppressor protein APC MTOR TRAF6 CYLD CTNNB1 PMC3410580__F2 Structure and interacting partners of p62/SQSTM1 NBR1 KEAP1 MTOR TRAF6 PMC4943213__F1 Wnt signaling APC GSK3B CTNNB1 PMC9599635__F1 Pathogenesis of Huntington’s Disease: An Emphasis on Molecular Pathways and Prevention by Natural Remedies TF TBP PMC3363966__F4 Components and targets of pro-phenol oxidase, Toll-Dorsal/Dif and JAK/STAT pathways TEP1 DDC TRAF2 MYD88 PMC3058199__F6 Noonan syndrome and clinically related disorders HRAS CBL RAF1 SPRED1 SOS1 SHOC2 BRAF CS GRB2 KRAS PMC9599635__F2 Pathogenesis of Huntington’s Disease: An Emphasis on Molecular Pathways and Prevention by Natural Remedies TF REST SIN3A TBP BDNF PMC5859860__F2 Proposed model of cross-regulation between LAP and canonical autophagy in p47phox−/− mice C6 PMC6739980__F3 Summary of ventral midline crossing ROBO3 DCC BOC SHH ROBO1 PMC9026123__F1 Cytotoxicity of Thiopurine Drugs in Patients with Inflammatory Bowel Disease NUDT15 TPMT PMC5398309__F2 Visible model is an excerpt of the KEGG (Kyoto Encyclopedia of Genes and Genomes) FoxO signaling pathway in humans as appears after importing in bStyle PRMT1 STAT3 IGF1 INSR SMAD4 CDK2 PTEN IGF1R MDM2 NLK SKP2 INS PMC3078187__F1 Signaling Cell Death from the Endoplasmic Reticulum Stress Response BAX MCL1 ATF4 EIF2A PMC7724774__F1 PD-L1 expression through NFKB EGFR MUC1 PMC2894370__F4 “Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology RHEB TSC2 PTEN HIF1A MTOR VHL PMC6399501__F3 Disorders resulting from mutational defects in the lysosomal SL degradation pathway GM2A HEXB HEXA GLA SMPD1 GLB1 PSAP PMC2825767__F2 Adrenal cholesterol biosynthesis pathway gene expression is globally underexpressed in the Chga knockout mouse HMGCR SQLE SC5D PMVK MVD DHCR7 FDPS IDI1 FDFT1 MVK PMC2825767__F1 Adrenal insulin signaling and glucose transport gene expression is overexpressed in the chromogranin A (Chga) knockout mouse STXBP4 EHD2 STXBP1 PIK3CA KIF3A RAB4A MAP3K10 MAP3K13 SLC2A4 MAP3K12 ARF1 PIK3C2G PIK3R2 GSK3B PIK3C2A PTPRF PRKCZ FLOT2 MAP3K11 MAP4K2 SOCS3 MINK1 SGK2 MAPK6 MAPK3 MAPK4 MAPK14 MAP3K2 MAP3K8 HEL-S-42 SOST GRB10 PIK3R4 MAP2K6 PDPK1 PRKCA TRIB3 CAP1 MAPK1 FLOT1 FOS RHEB CRK TSC2 PRKCI TSC1 MAP3K1 PRKCQ FOXO1 SOS2 MAPK7 MAP3K7 MAP2K5 MAP3K5 GRB2 HEL-S-31 SNAP23 RRAD VAMP2 GYS2 PPP1CC RPS6KB2 PTEN SHC2 SH2B2 MAP3K14 ENPP1 XBP1 PRKCH MAP2K4 INSR GYG1 MAP2K3 SHC3 MAP4K3 JUN MAP4K1 PTPN1 PTPN11 IRS4 RAC1 CBL GYS1 RPS6KB1 IKBKB PRKAA2 LIPE SNAP25 INPPL1 GRB14 MAP3K6 TBC1D4 STXBP3 EHD1 PMC5953777__F3 Cancer-relevant signaling pathways BAX CSA2 BAD CAD ROCK1 CP PMC2825767__F3 Hepatic cholesterol biosynthesis pathway gene expression is globally overexpressed in the Chga knockout mouse HMGCR SQLE SC5D PMVK MVD DHCR7 FDPS FDFT1 MVK PMC9652939__F9 MICAL1 facilitates pancreatic cancer proliferation, migration, and invasion by activating WNT/Beta-catenin pathway MICAL1 APC GSK3B FZD7 AXIN1 CTNNB1 PMC5953777__F2 Connectivity of differentially expressed genes in the important cancer signaling pathways in the exposed children are shown according to gene expression levels (with ≥ 1.5-fold change, t test, p < 0.05) NFKB2 MYC CP PMC10995750__F3 Genes enriched in plasma membrane estrogen receptor signalling pathway NR1i1 CCND3 JUN BAG1 PPP2CA NCOA6 NCOA1 FOS TRRAP RB1 STAT1 RUNX1 c-fgr NCOR1 POU2F1 CSNK2A1 GRB2 SMARCA4 PMC3599951__F5 Phytochemicals targeting NFkB signaling pathway BAD PTEN PMC10540768__F2 Unleashing the power of complement activation: unraveling renal damage in human anti-glomerular basement membrane disease MASP1 C6 MASP2 HEL-S-62p C2 C1S C1R C9 C4A PMC4027049__F2 TGFB signalling in context TGFBR2 BMPR2 SMAD4 ARHA RHO TRAF6 DROSHA PMC5466034__F10 A Putative Model of Central Carbon and Energy Metabolism in Tomato GTs.A type VI glandular cell with its plasma membrane as a black line C6 IPP MAL CIT PMC9367255__F2 Autophagy-Associated Immunogenic Modulation and Its Applications in Cancer Therapy ATG3 TLR7 TRAF6 ATG5 PMC8690896__F1 E-cadherin on epithelial–mesenchymal transition in thyroid cancer CXCL12 EGFR DPP4 BRAF PTEN MTOR CXCR4 TNF PMC2749270__F1 Sphingosine-1-phosphate synthesis and functions in mast cells FYN SPHK2 SPHK1 LYN PMC3261582__F1 JNK signaling enhances the compensatory proliferation of the neighboring cells, stem cells or cancer stem cells (CSCs) KLF4 CD44 SOX2 MYC CCND1 PMC6399501__F2 Mechanisms of pathogenesis of inborn errors of SL metabolism CERS3 UGCG HEXB SPTLC2 SGPL1 SPTLC1 KDSR PMC6399501__F1 Disorders resulting from mutational defects in the SL synthesis pathway for ceramide and GSLs and the nonlysosomal SL degradation pathway CERS3 UGCG SPTLC2 ORMDL3 B4GALNT1 SGPL1 CERS1 ST3GAL5 SPTLC1 KDSR ACER3 PMC12055549__F0 Proposed signaling pathway of tetramethylpyrazine (TMPZ) in protecting against acute pancreatitis through inhibition of pyroptosis via the NRF2 pathway GSDMD NLRP3 PMC7906182__F4 Interacting networks between coiled-coil domain-containing protein 167 (CCDC167) and micro (mi)RNA SP1 AGO2 SMAD2 IGF1R MMP9 RUNX2 SFRP1 HOXA2 PKD1 NOG BMP2 MMP2 GAD2 ATF4 HEL-S-26 PMC3012182__F1 TRPM channels in insulin secretion TRPM2 TRPM5 MLSN2 PMC7906182__F3 MetaCore pathway analysis of coiled-coil domain-containing protein 167 (CCDC167)-co-expressed genes in breast cancer patient databases CDC2 TCP1 CDC20 RASSF1 APC CDK2 CS PLK1 SKP2 PMC8624906__F2 Transcriptional Regulation of Ripening in Chili Pepper Fruits (Capsicum spp.) MYB CCS PMC199181__F2 Proposed mechanisms of NFKB activation in HIV-1–infected cells TRAF2 FADD PMC7772706__F3A Based on network pharmacology method to discovered the targets and therapeutic mechanism of Paederia scandens against nonalcoholic fatty liver disease in chicken MAFK TRADD TIRAP SP1 SP2 ARHA MYC TRAF6 SKI NAIP RILP RALA NLRP3 HEL-S-162eP AHI-1 AHNAK IL1B FADD PMC199181__F3 The NFKB pathway by viruses TRADD TNF TRAF2 PMC4425424__F3 Transcriptional regulation of cranial sensory placode development MSX1 ZIC1 FOXI1 PMC6124012__F6 Sterol regulatory element-binding protein 1 signaling FASN LDLR DHCR7 PMC11414398__F7 Alternative Src regulatory pathway mediated by the METTL18-RPL3-HSP90-actin axis in HER2-negative breast cancers RPL3 METTL18 SRC PMC6406790__F1 The schematic diagram represents the treatment schedule and the mechanism of NAM neuroprotection in mouse brains BAX CASP3 BCL2 IL1B PMC11023816__F9 Proposed pathways by which paracrine and autocrine cytokine signaling modulates vitamin A metabolism across stellate cell activation phenotypes RARB CRABP2 LRAT TLR4 RBP4 TRAF2 IL6R MYD88 PMC8771518__F7 Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis GSDMD NLRP3 IL1B PMC7415260__F4 Signaling pathway visualization based on changed protein and transcript expression of SYN1, SYN2, SYN3, SNAP25, STX1A, RAB3A, and STMN1 in recurrent samples SYN2 VAMP2 SNAP25 STX1A SYN1 PMC3544784__F1 Insight into the role of CRMP2 (collapsin response mediator protein 2) in T lymphocyte migration CXCL12 CDK5 GSK3B CXCR4 PMC2387183__F4 Autocrine/paracrine induction of osteogenesis in hMSCs by PKA signaling FOSB ID2 IGF1 ID4 BMP2 SMAD6 PMC9424640__F7 Therapeutic potential of NR4A1 in cancer: Focus on metabolism COX2 MSC CD34 PMC11786761__F9 SH2B1 promotes apoptosis in diabetic cataract via p38 MAPK pathway BAX BCL2 SH2B1 PMC5453624__F5 Comparison of the adolescent and adult mouse prefrontal cortex proteome STXBP1 CPLX2 GAP43 CRMP1 BDH1 GSTM5 LPAR1 MTOR PPP3CA DPYSL3 CNTF RICTOR DLGAP1 NTF4 FABP5 PTBP1 HEL-S-162eP ATXN1 UQCRC2 ARHGEF7 BDNF ZDHHC8 EIF2AK2 PMC3791178__F1 The Autophagy Pathway by Human Tumor Viruses ATG3 ATG12 MTOR ATG5 PMC11023816__F1 Vitamin A metabolic pathway and the enzymes involved in retinoid metabolic flux in human liver CYP26B1 PNPLA3 HEL-S-53e CRABP2 LRAT CRABP1 RBP4 RDH10 ALDH1A2 RDH11 CYP1B1 CYP26A1 PMC5453624__F7 Comparison of the adolescent and adult mouse prefrontal cortex proteome TH PPARG NOS2 CPLX2 ADORA2A ENO2 SNCA PTEN RANBP9 HEL-S-30 PSEN1 FMR1 CAMK2A MBP HEL-S-162eP CLTA KNS2 APP HEL-S-15 PMC8939123__F1 Sirtuin family members in chronic obstructive pulmonary disease STAT3 PGC SIRT7 NLRP3 SIRT4 SIRT2 CTNNB1 SIRT6 PMC4163877__F2 Integrated signaling networks and tumor cellular bioenergetics TSC2 AAMP TSC1 MTOR PMC11985700__F1 Key signalling pathways involved in muscle atrophy and hypertrophy RHEB TSC2 REST TSC1 IGF1 SMAD2 MTOR PMC3988951__F6 Insights into TREM2-related signaling using data-driven network constructions and information provided by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis LAPTM5 TREM2 GPR34 SYK VASP HEL-S-62p LAT ARF6 TOB2 CYBB DOCK2 PMC7139637__F4 YAP drug targets LATS1 BRD4 LATS2 SRC PMC4433473__F4 Surface Fzd density by R-spondin-LGR5-RNF43 RNF43 APC LRP5 ZNRF3 LRP6 TCF4 CTNNB1 PMC8877508__F1 Relevance of TLR8 in Viral Infections TLR8 IRF3 IRF7 TLR7 TRAF6 MYD88 PMC7139637__F3 Crosstalk between YAP signaling pathway and both TEAD and TGFB pathways LATS1 TBR1 LATS2 SMAD2 SMAD4 PMC4433473__F3 Ligand-dependent LRP6 endocytosis DKK1 LRP5 LRP6 TCF4 CTNNB1 PMC7218640__F1 CRNDE significantly promotes cell proliferation through mediating multiple signaling pathways and various target genes STAT3 CCL18 IRX5 HNRNPUL2 E2F3 GSK3B PIWIL4 TCF4 MTOR CTNNB1 PMC4759558__F12 CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone STAR CMKLR1 BMP4 PMC7139637__F1 Hippo/yes-associated protein (YAP) signaling pathway in mammals LATS1 BIRC5 LATS2 NF2 PMC8197279__F2 Damage-Associated Molecular Patterns Modulation by microRNA: Relevance on Immunogenic Cell Death and Cancer Treatment Outcome HMGB1 PMC3049335__F1 The Nrf2 pathway in PD pathogenesis TFAM KEAP1 NQO1 MAF PRX PMC6356367__F3 Upstream factors of the TOR pathway RHEB EGF EGFR PMC5525309__F1 Innate immunity TLR1 TLR3 TLR4 APC TLR9 TLR8 CSK TLR7 PMC6549764__F3 15d-PGJ2 regulates adipocyte differentiation and osteoblast differentiation via a PPARGamma-dependent pathway MSC RUNX2 CTNNB1 PMC8194229__F3 Novel method to identify gene interaction patterns NAPA KIF3A DCTN4 VPS52 RAB6B COPE VAMP4 SPTA1 KIF12 VPS54 SEC16A NAPG BICD2 STX18 KIF3C SCN7A RAB34 SPTBN2 KIF3B KIF1B TFG DCT COPA KIF1A SEC24C TMF1 CPA4 GBF1 KIFAP3 SEC22A GORASP1 ARF3 COG2 PMC7395429__F7 Proposed model for MBP-induced abnormal cell growth of juvenile SCs CDC2 MBP IRAK1 PMC7663205__F2 Role of PITPNM3 in cancer cell migration CCL18 GSK3B VCAM1 MTOR PITPNM3 PMC7894993__F2 Extrinsic and intrinsic factors that regulate self-renewal in embryonic and adult haematopoiesis SOX17 EZH1 MPL TET2 LIN28B ITGAM SPRED1 EZH2 ATF4 GFI1 PMC6496801__F4 The primary molecular pathways leading to pyroptosis in monocytes/macrophages in CVDs GSDMD NLRP3 CD36 PMC11043957__F2 Nrf-2 and signaling pathways CSA2 MAP3K7IP1 SMAD2 NQO1 SMAD4 PMC11043957__F1 Signaling pathways in radiation-induced lung injury SMAD2 SMAD4 IGFBP7 PMC6496801__F2 Multiple pathways that mediate pyroptosis TXNIP IRF9 AIM2 IRF7 ARHA TRAF6 MYD88 NLRP12 GSDMD NLRP3 TLR4 TYK2 BRCC3 FADD PMC6496801__F1 Caspase‐1–dependent and independent pyroptotic pathway GSDMD NLRP3 AIM2 RHO PMC10875826__F1 (i) ERBB/HER family members and their cognate ligands (ii) Structural difference of various (I-VI) types of NRG1 RHEB NRG2 EGF TSC2 NRG1 HBEGF NRG3 NRG4 PMC8305013__F1 Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention DCT KIT PMC7550420__F2 Process and regulation of STING trafficking TBK1 YIPF5 MTMR3 ATG9A MTMR4 IRF3 SNX8 PMC7550420__F1 Diagram of STING-mediated immune response to viruses TBK1 CGAS IRF3 PMC100005__F11 Formation of TrkA–src-aPKC complexes FRS2 SRC TRAF6 PMC7185083__F5 PTEN may regulate autophagy by allowing for a bypass of PTEN/PRAS40 signaling in TSC2-/- cells and influence cell proliferation RHEB TSC2 TSC1 PTEN PMC7559772__F2 Genetic regulation of cell fate and size of the progenitor zone TPH1 CDK2 PMC6386770__F1 Differences in the functional impact of IL-7/IL-7R-mediated signaling in T-ALL cells and their normal counterparts JAK3 MTOR JAK1 BCL6 PMC5525309__F6 Working model of metabolic risk factor-induced two-way stimulatory immune checkpoint amplification and systemic/tissue inflammation LPL CD40 STAT3 APC PMC8113818__F2 Unfolded protein response (UPR), autophagy and coronavirus (CoV) infections ATG14 ATG5 PMC8511434__F4 Type 3 Innate Lymphoid Cells as Regulators of the Host-Pathogen Interaction STAT3 NLRP3 STAT4 LCN2 TNF FFAR2 RUNX3 PMC5951756__F4 Insulin/IGF-1 signalling map CDC42 ACLY BAD SHC1 SOS1 AKT3 GSK3B PTEN IGF1R MTOR SH2B2 FOXO4 INSR CAP1 EIF4B CAV2 EXOC7 FRS2 IRS4 IRS1 EIF4E CAP2 RHEB CRK TSC2 CBL TSC1 GSK3A IGF1 FOXO1 RPS6KB1 RAPGEF1 GRB2 GAB2 EHD1 PMC8511434__F6 Type 3 Innate Lymphoid Cells as Regulators of the Host-Pathogen Interaction VIT NR1i1 VIP STAT3 CCR6 VIPR2 MTOR IL1B PMC4715089__F1 TGFB/Smads and crosstalk pathways in renal fibrosis and inflammation SMAD2 SMAD4 IL1B PMC4192457__F2 Signaling pathway regulation of autophagy by several factors ULK1 UVRAG ATG14 BNIP3 MTOR PMC3562679__F1 Lipopolysaccharide (endotoxin) signaling pathway TLR4 CD14 TRAF6 LBP MYD88 PMC3527539__F7 Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells EGF EGFR SMAD2 TCF4 CCND1 CTNNB1 PMC3709966__F4 HIV-1 Vpr Modulates Macrophage Metabolic Pathways: A SILAC-Based Quantitative Analysis HEL-S-99n ACTG1 STOML2 MYH1 HSD17B10 DKFZp686P11128 ILF3 RHO PMC8650317__F1 Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts TRO AHR PMC3906243__F6 Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets FH DHFR CHDH PMC10245950__F9 ß-oxidation pathway for fatty acids is strongly downregulated by oxaliplatin C6 ECHS1 ACAT1 HADHB ACSL1 OGDH CPT2 PMC4816150__F2 Adiponectin signal transduction pathway implicating a crosstalk with the insulin signaling pathway APPL1 MTOR IRS1 PMC7970116__F3 Genomic characteristics of ccRCC for manipulating the TIME IFNG POLI ARG1 PTEN CXCL10 CCL2 VHL PMC11787754__F8 EA treatment might activate the mitophagy-related PINK1/Parkin signaling pathway through lncRNA-XR_002789763 PINK1 PARL MFN2 OPTN PMC7970116__F2 Bidirectional Relationship between targeted therapies (VEGF/VEGFR inhibitors) and TIME in ccRCC CXCL12 CCR2 IL8RB CCL2 CXCR4 FGF2 PMC5977762__F2 Up-regulation of the JAK-STAT and mTOR pathways: Ingenuity pathway maps for a JAK-STAT signaling (transducing extracellular signals to transcriptional responses) and b mTOR signaling (a master regulator for many fundamental cellular repair processes) TSC2 REN GAS IL4 PC INS DAO PMC7970116__F1 Mechanisms influencing immunotherapy response in the TIME in ccRCC ARG1 LAG3 ADA PMC4102648__F2 UV signaling pathways within the skin MC1R PDE4D TYRP1 PMC11787754__F1 PINK1-dependent mitophagy PINK1 PARL MFN2 OPTN PMC9385636__F7 Salidroside alleviates hepatic ischemia–reperfusion injury during liver transplant in rat through regulating TLR-4/NFKB/NLRP3 inflammatory pathway NLRP3 IL1B MYD88 PMC9406578__F2 Targeting Heat-Shock Protein 90 in Cancer: An Update on Combination Therapy STAT3 ATM HEL-S-28 PMC6482176__F1 The Insulin Signalling Pathway and insulin resistance RAB10 PTEN IRS1 PMC9043866__F8 TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NFKB pathway BAX CASP3 IL1B PMC3251736__F2 Ingenuity pathway analysis (IPA) of the EGFR ablation signature with oncogenic (A) and wildtype Ras (B) IL17F VPS13A MATK GOLIM4 KIF11 TIMP3 ID2 CDC6 SMAD2 CXCL1 TMPRSS11E DUSP9 SP2 CD46 GCGR CR1 MYLK3 SSTR4 INHBB NR2A1 HABP2 PIGR PMC7729585__F2 Fatty acid metabolism, glycolysis, and tricarboxylic acid cycle (TCA) cycle MCAT PDK4 ALDOB SLC37A4 ME2 PPT1 PDC PDK3 PDK2 CPT2 HEL-S-26 SDHC PMC4858538__F4 Role of p38 MAPK in Wnt signaling DVL1 GSK3B LRP5 LRP6 TCF4 CTNNB1 PMC9109300__F7 Silencing of histone deacetylase 3 suppresses the development of esophageal squamous cell carcinoma through regulation of miR-494-mediated TGIF1 HDAC3 SMAD2 SMAD4 PMC5329966__F3 Heterogeneous responses of normal and malignant B cells upon CpG ODNs stimulation BAX STAT1 CD80 FAS TLR9 IRAK1 TRAF6 IRAK4 MYD88 PMC10143138__F2 Osteoblast cellular cholesterol homeostasis TG HMGCR LDLR PMC6917641__F1 Drugs with clinical potential in cancer that modulate miRNAs implicated in cell metabolism SP1 SIX1 HK2 ZEB2 MTOR GABPA NR3B3 IRS1 PMC9563854__F3 Natural antisense transcripts as drug targets USP14 MDM2 SMURF2 PMC10253382__F3 Anti-inflammatory pathways induced by baicalin HMGB1 NLRP3 FOXO1 TLR4 GSK3B SOCS3 PMC8841999__F1 ER Disposal Pathways in Chronic Liver Disease: Protective, Pathogenic, and Potential Therapeutic Targets UFD1L CCPG1 CYP2E1 TEX264 SEL1L APOB ATL3 STX17 VAMP8 SEC62 PMC5748990__F2 Pathways regulating senescence-mediated arrest CDK6 MDM2 CDK4 PMC4403295__F2 ER-mitochondrion tethering VAPB FIS1 NLRP3 MFN1 MFN2 PML PTEN PMC8207264__F6 Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8− Positive (AT8+) Tau in Alzheimer’s Disease ASL HEL-S-20 OTC MTRR CIT PMC4403295__F1 The UPR signaling pathway ELF2 ATF4 XBP1 PMC9029304__F1 Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications TSC2 TSC1 MTOR CCND1 IRS1 PMC6169995__F3 Differential targeting of genes in the drug metabolism pathway HEL-S-22 MGST3 HEL-S-21 GSTT2 LOC51064 MGST1 MAOA ADH5 ALDH1A3 GSTA4 MGST2 ALDH3A1 FMO4 ADH1C HEL-S-117 UGT1A3 AOX1 GSTM2 GSTM5 CYP2C18 PURA ALDH3B2 GSTM4 CYP2B6 GSTM1 UGT2B15 GSTM3 GSTZ1 ALDH3B1 GSTT1 CYP3A4 PMC8875462__F4 Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia–reperfusion injury in mice MMP7 SIAH1 APC SMAD4 RYK ARHA BAMBI RBX1 SOST INVS CBY1 NOTUM CER1 SKP1 NLK GPR49 LGR6 PMC6277637__F3 Main brain-immune system pathways and feedback loops illustrating the interconnected effects of physical and emotional stress in health CRP TRH C2 AVP PMC9136512__F10 CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth CDC2 BAX CHEK2 CHEK1 CDK5RAP3 MTOR RPL26 PMC4772904__F1 NSAIDs inhibit PGE2-induced tumorigenesis through targeting multiple downstream signaling pathways of PGE2 COX1 EGFR GSK3B CTNNB1 PMC8353915__F6 VLX1570 induces apoptosis through the generation of ROS and induction of ER stress on leukemia cell lines MAX USP14 ATF4 EIF2A XBP1 ADA PMC3495983__F6 Model illustrating CD40-induced signals that mediate the expression of VEGF in endothelial cells CD40 MLST8 RICTOR MTOR PMC4786283__F2 Stability of Ensemble Models Predicts Productivity of Enzymatic Systems HEL107 RPE TTK EN1 PMC8310438__F1 Corrigendum to “Expression and Gene Regulation Network of Metabolic Enzyme Phosphoglycerate Mutase Enzyme 1 in Breast Cancer Based on Data Mining” HEL-S-133P HSD17B10 TIGAR TYMS HEL-S-30 PGAM4 AP2M1 PGAM2 PRCP PFKP HEL-S-49 HEL-S-162eP CHUK MDM2 HEL-S-87p PMC11465581__F8 The effect of neuroinvasion on immune tolerance in NSCLC NGF released from NSCLC cells induces neuronal cell differentiation and axonogenesis in the tumor microenvironment (TME) NGF HTR1D MTOR PMC9611604__F7 How does Quorum Sensing of Intestinal Bacteria Affect Our Health and Mental Status? IFNG AHR CYP1A1 CTNNB1 PMC5608833__F10 Rep-MYB-mediated repression of G2/M-specific genes under DNA stress conditions MYB ATR ATM PMC3942330__F6 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms RAP2C RAP2A RAF1 KSR1 EPHB1 ARHA TNIK PMC3942330__F5 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms CDC42 SH3BP1 VAV2 EGFR CD2AP SRC PMC3000836__F1 Comparison of the DC-ATLAS Toll Like Receptor (TLR) 3 pathway with other pathway databases PTER CD40 tal-1 CDA TIRAP CD14 IL6 TNF EFS IRAK4 PMC3942330__F4 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms CASP9 EGF EGFR CASP3 SRC RAC1 PMC6281690__F4 Schematic illustration representing metabolic and transport proteins hypothesized from the genome of Ca FH INA AGA RGR PMC3519537__F5 Using Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing RHEB RPS6 EEF2K RICTOR TSC1 C2 PTEN PMC3942330__F3 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms CXCL12 ARHGEF11 ROCK2 ROCK1 CASP3 ARHA CXCR4 PMC6305103__F2 Tumor metabolism regulating chemosensitivity in ovarian cancer LPA HEL-S-162eP BRAF PTEN TIGAR HEL-S-30 MYC KRAS PMC6823874__F1 Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response POR POLI POLE PMC10309183__F4 Ether lipids and a peroxisomal riddle in sperm DHRS7B AGPS GNPAT HMFN0839 GPAT4 FAR1 GPAT2 PMC11393989__F1 Molecular and cellular mechanisms of TGFB signaling pathway in GO DVL1 FZD4 SOX9 SMAD2 LRP5 SMAD4 LRP6 ARHA NOX4 PMC3942330__F8 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms GBF1 ARFRP1 ARF1 ARF6 SRC PMC6920345__F3 The impact of oncogenic RAS on redox balance and implications for cancer development HMOX1 JUN ACSL3 GCLC MAL ATF4 MYC PMC3855668__F1 Model of the signaling pathway mediated by ATM in response to DSBs induced by IR, as proposed by Kitagawa et al RAD50 MRE11A BRCA1 H2AX ATM MDM2 PMC3519537__F1 Using Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing RHEB EEF2K DCP2 RICTOR C2 CASK AGA MYC DST PMC11826106__F9 CSRP2 inhibits the necroptosis of glioma cells by activating the JAK-STAT1 signaling pathway RIPK3 STAT1 CSRP2 MLKL PIAS1 RIPK1 PMC4371597__F1 Evaluation of the Unfolded Protein Response: PI 3-Kinase Regulatory Subunits as Regulators of the IRE1A Pathway ATF4 EIF2A PMC8043893__F9 SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation LATS2 LIMD1 CARMIL2 SKI PMC3123739__F8 DNA Repair Deficiency in Neurodegeneration TDP1 RAD52 RAD51 LIG1 FEN1 WRN RNF8 ATM TPO MDC1 BLM XRCC3 PMC4417967__F2 Relative adenine and thymine (%AT) DNA content of ergot alkaloid synthesis (EAS) loci AFP CDC45 PRL F11 PMC7521342__F5 Global gene expression analyses of the alkamide-producing plant Heliopsis longipes supports a polyketide synthase-mediated biosynthesis pathway AFF1 AFF2 AFF4 PMC5260500__F3 DAB2IP in TNFA signaling: activation of ASK1/JNK CSA2 TRADD DAB2IP TNF TRAF2 PMC8061373__F1 Schematic hypothesis of the proposed mechanisms of TLR3 derived from SARS-CoV-2 leading to hypertension TBK1 TLR3 IRF3 ACE2 STRAP PMC7062180__F1 A, the mammalian polyamine metabolic pathway SMS SRM SMOX PAOX PMC9592233__F5 Lipid Profiling of Pacific Abalone (Haliotis discus hannai) at Different Developmental Stages Using Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry LPA TG PC PMC2798676__F10 Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling CDC42 SCARA5 CRK RHO GRB2 MMP9 SRC CCND1 PMC1829400__F5 TGFB signaling pathway NOG MYC DCN PMC12072309__F1 Schematic illustration depicting the dysregulation of the NF2/Merlin-Hippo signaling cascade in mesothelioma cells LATS1 LATS2 AJUBA YAP1 PMC4581967__F1 Evasion and Interactions of the Humoral Innate Immune Response in Pathogen Invasion, Autoimmune Disease, and Cancer MASP1 C6 C7 CS C4A PMC8452443__F3 Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis ICOS KLF2 FOXO1 APC CCR7 CXCR5 BCL6 PMC8391678__F2 LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases ROCK2 PAK1 LIMK1 RHO BDNF RAC3 RAC1 PMC10955039__F6 Hippo signalling pathway in ferroptosis EMP1 ANGPTL4 GPX4 FACL4 SLC7A11 NOX4 PMC2649808__F5 Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions CRK FAS CBL HEL-S-5 GOPC GRB2 MTOR PMC3387654__F1 Mammalian Hippo pathway and cancer LATS1 LATS2 NF2 PMC7965781__F1 Control of the insect metamorphic transition by ecdysteroid production and secretion C6 HEL-S-62p SHD PMC6966089__F2 Methanol condensation cycle (MCC) for assimilation of methanol into higher alcohol with maximal carbon conservation HEL107 RPE MCC PMC8354137__F1 Exploring the contribution of the mitochondrial disulfide relay system to Parkinson’s disease: the PINK1/CHCHD4 interplay PINK1 PARL CHCHD4 PMC3807098__F1 Squalene Synthase Inhibitor Lapaquistat Acetate: Could Anything Be Better Than Statins? CDC42 ARHA RAC1 PMC4166715__F4 mTOR transcriptional activity RPS6 EIF4B RRAGB RRAGD PIK3R3 BRAF PTEN HIF1A IGF1R MTOR SET IRS1 RHEB TSC2 RICTOR TSC1 PDPK1 PRKAA2 RRAGA PMC2151969__F4 Genes up-regulated and down-regulated by FGF-2 in IGF-I signaling pathway ICE1 ALK IGF1 PAX2 IGF1R PMC2151969__F5 Genes up-regulated and down-regulated by FGF-2 in TGFB signaling pathway NR1i1 FOXH1 JUN SMAD2 TLX2 GSC NODAL HOXC8 FOS PITX2 PMC4905175__F1 Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis ATM RIF1 POT1 PMC7227208__F6 TGF-beta signaling pathway enriched in KEGG FBN1 THBS1 THSD4 SP1 SMAD2 SMAD4 NODAL ARHA TNF HFE2 BAMBI IFNG RBX1 E2F4 FST NEO1 SKP1 PMC5412951__F1 Glucocorticoids Inhibit Wound Healing: Novel Mechanism of Action GC GSK3B CTNNB1 PMC9601711__F1 Hereditary Metabolic Bone Diseases: A Review of Pathogenesis, Diagnosis and Management NR1i1 CYP2R1 DBP WAS HNRNPC CYP3A4 FGF23 PMC2556276__F1 Display of differentially expressed genes in the uterine cervix after term spontaneous labor mapped on the PLAU signaling pathway HGF RAF1 EGFR PLAUR PLG HEL-S-28 VTN HRAS STAT1 PLAT SERPINE2 GRB2 JAK1 SRC NCL PMC8660968__F1 Regulatory Mechanism of 2-Acetyl-1-Pyrroline Biosynthesis in Fragrant Rice (Oryza sativa L.) Under Different Soil Moisture Contents PRODH DAO PMC12210776__F4 Key mechanism diagram of the combination of JZOL and AZ in the treatment of MPP MMP14 SELE CXCL1 MMP3 PTGS2 TNF CCL20 PMC8023395__F2 Towards personalized treatment for early stage HER2-positive breast cancer PTEN MTOR SRC PMC6141803__F2 Indoximod mechanisms of action IDO1 KMO AHR IDO2 PMC6321366__F3 Schematic overview of RAS and PI3K pathway and their interconnection RHEB TSC2 TSC1 PTEN PMC2774790__F6 Proteome Profile of Functional Mitochondria from Human Skeletal Muscle Using One-Dimensional Gel Electrophoresis and HPLC-ESI-MS/MS ECHS1 ACSL3 ACO2 ACADSB ACADS HSD17B10 CS ACADM DECR1 SDHA PDHA1 ACSL1 HADHB DLAT SUCLG1 SUCLA2 OGDH SUCLG2 ACADVL HEL-S-32 MDH2 CPT2 PMC4715161__F2 Transforming growth factorB (TGFB)-activated kinase 1 (TAK1) activation by TGFB in mesangial cells MAP3K7IP1 SMAD2 SMAD6 SMAD4 ATF2 TRAF6 PMC3928987__F2 Cyclooxygenase pathway of AA COX1 PMC4023255__F5 TGFB family signaling for Müllerian duct regression SMAD1 DKFZp781O1323 BMPR1A ACVR1 MMP2 AMHR2 AMH CTNNB1 PMC7692401__F1 Autophagy–lysosomal–endosomal system and the Parkinson’s disease (PD)-related proteins SCARB2 PINK1 SYNJ1 LRRK2 PARK2 DNAJC6 TMEM175 SMPD1 HEL-117 VPS35 HEL-S-130P FBXO7 VPS13C PMC4374766__F5 Macrophage Gene Expression Associated with Remodeling of the Prepartum Rat Cervix: Microarray and Pathway Analyses FLT3 FERMT3 SLA HCLS1 PGR IKBKE CCR2 IFIT3 EPB41L3 PTPRC PRKCB PLEK MAP3K8 BTK CCR7 TLR7 ARL11 DLX3 ACHE MATK FOSB ITGB7 PCDH7 SPTBN2 MMP17 ITGB3 EGR4 HVCN1 MRC1 SAP25 RHOB TP63 HEL-S-102 CMTM3 HAS2 NOSTRIN TRIM29 PIGR BDKRB2 PMC2522268__F1 Interferon-inducible antiviral effectors IFNGR2 IFNAR2 TYK2 PMC6986718__F3 Impact of genotype, body weight and sex on the prenatal muscle transcriptome of Iberian pigs CRK FRK GRB2 NR0B2 TRAF2 PMC8602339__F1 Searching for DNA Damage: Insights From Single Molecule Analysis ERCC1 XPA POLL POLI XPC PMC3691611__F7 The proposed pathways that regulate astroglial CNTF STAT3 CNTF THY1 LIF IL6 PMC7530064__F9 Diagram of signaling pathway of IQGAP1 in regulation of VEGFR2-Src-Rac1 activation in choroidal angiogenesis VAV2 IQGAP1 SRC RAC1 PMC4505740__F1 Molecular targeting of the mitogen-activated protein kinase (MAPK), PI3K, and CDK4 pathways and the associated mutation rates of potential molecular targets in advanced melanoma () JUN BAD ERBB4 NF1 AKT3 GNA11 NRAS KIT BCL2 PTEN FOS CDK4 PMC9441553__F5 Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts by regulating the LPS-induced apoptosis signaling pathway C1QTNF2 PAFAH2 MARCKS TREH APP CALCA PSAP FAM3A CP PMC5744685__F1 Targeting Metabolism for Cancer Therapy OMP DHFR DHODH PMC5744685__F8 Targeting Metabolism for Cancer Therapy MTAP MTR PMC3740364__F1 Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways TBK1 MAVS TRIM25 IRF3 TRAF3 TRAF6 PMC7277093__F12 Multiple modes of AOAA’s action on H2S producing pathways and other transaminases in cancer cells GOT2 GPT PMC10348770__F1 Treg-mediated immunosuppression and resolution of lung inflammation VAV1 TNF RAC1 PMC7140047__F2 Rac1 signaling pathways and their biological significance STAT3 BAD NOXA1 LIMK2 LIMK1 PTEN ARHA RHO PLK1 RAC1 PMC6318069__F1 Three tooth agenesis-associated signaling pathways Pax9 MSX1 APC GREM2 EDARADD TRAF6 EDAR AXIN2 pp6425 TNLG7C CTNNB1 PMC6391768__F7 Schematic illustration of vitamin D/VDR’s regulation on HIF-1A as well as IFNG and IL-1B in oral keratinocytes NR1i1 IFNG TLR4 IL1B VHL PMC9597127__F3 Major STING combinatorial approaches with additive or synergistic effects STAT3 CGAS APC PMC9576928__F2 Advancement in understanding the role of ferroptosis in rheumatoid arthritis SLC3A2 ACSL3 GPX4 SCD LPCAT3 FACL4 SLC7A11 STAT1 FTH1 TFRC LOX FTL STEAP3 ALOX15 ATG5 HEL-S-64p HEL-75 PMC6795686__F8 The signaling pathways regulating TREM2 phagocytosis and TREM2 modulation of NFKB phosphorylation/activation TREM2 SYK PMC3937046__F7 Neuronal circuit diagram of the light input pathway in the tadpole retina TH PROX1 ISL1 OTX2 PAX6 PMC4756853__F4 Pathways involved in thymidine synthesis in Escherichia coli, Drosophila melanogaster and humans DCD DHFR DCTD DUT PMC6770402__F5 Apoptosis pathways (hsa04210) and targets of cordycepin TH BTD DOP1A PMC6719933__F4 Transcriptional regulation of GRINA and its role in cell survival NR1i1 GRINA TMBIM6 ATF4 PMC8107720__F5 Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer FGF8A STAT3 FGFR4 GSK3B ATF4 PMC7281533__F4 Reactive oxygen species (ROS) promote cellular inflammatory response and oxidative damage, which may impact cell and tissue viability in the lungs VIT BAX KEAP1 PMC9338059__F2 KOPI: Kinase inhibitOr Proteome Impact analysis CTRL NONO EGFR THRAP3 TANK MAP2K2 RHO ACACA FECH MYC SGTA STS PMC3969565__F1 Emergence and Evolutionary Analysis of the Human DDR Network: Implications in Comparative Genomics and Downstream Analyses RAD18 TERF2 SLX1B FANCM FANCL PLK1 MAPK3 HERC2 FANCD2 BABAM1 TRIM28 WEE1 PARP2 MDM2 SOX4 TDP1 TAOK1 MSH6 ATRIP MSH2 KAT5 MSH3 TIMELESS NHEJ1 UIMC1 USP11 SMC5 POLI MDC1 RBBP8 UBE2T XPC BARD1 XRCC5 HEL-S-71 RBX1 DDB1 CUL4A MRE11A BRCA1 ERCC5 SIRT1 ERCC1 XPA ATR PAXIP1 PCNA CLSPN BLM UBR5 BTRC TOP3A DNA2 CHEK2 RNF8 ATM HEL2 RMI2 SSB PARP1 SMARCAL1 PRKDC CHEK1 PIAS1 SKP1 KAT8 SLX4 EME1 RMI1 PMC24579__F6 Integration of tyrosine kinase signaling to both cAMP and MAPK 1,2 pathways, resulting in cell cycle arrest and the reduction of MAPK 1,2 triggered proliferation MAPK1 MAPK12 CCND1 PMC8025927__F1 Schematic model depicting the mechanisms of meiotic arrest NPPC TGFBR2 CDC2 KDM1A APC NPR2 GPR3 CCNB1 FSHR PMC3185772__F2 Regulation of Blood-brain barrier permeability, entry of WNV in the brain and factors involved in the pathogenesis of WNV-induced neuroinvasisve disease CXCL12 TLR3 PLG CXCL2 PMC7439920__F3 Critical role of HGMB1 in the complex interplay between apoptosis and autophagy RHEB HMGB1 ATG12 HEL-S-102 PMC2635670__F1 Apoptosis pathways: The extrinsic or death receptor pathway (left) is triggered by members of the death receptor superfamily such as Fas BAX FADD PMC6720817__F4 Intracellular signaling involved in cardioprotective response stimulated by ischemic postconditioning (PostC) in cardiac cells BAX BAD GSK3B PMC6720817__F3 Intracellular signaling involved in cardioprotective response stimulated by ischemic preconditioning (PreC) in cardiac cells BAX BAD EGFR GSK3B SRC PMC9312859__F7 FGFR2c/PKCE Axis Controls MCL-1-Mediated Invasion in Pancreatic Ductal Adenocarcinoma Cells: Perspectives for Innovative Target Therapies MCL1 MTOR FGF2 PMC2826677__F1 T-cell activation, proximal signalling complex and activation of transcription factors ZAP70 PLCG1 RAF1 BCL10 LAT ITK GRB2 LCK PMC9399644__F5 Advances in the study of HSP70 inhibitors to enhance the sensitivity of tumor cells to radiotherapy EGFR SMAD2 SRC PMC6913740__F7 Carbohydrate metabolic pathway in ‘outer tissues', endosperm, and embryo of a barley grain and the differential transcript expression of involved genes in 18-6 transgenic grain from 7 to 24 DAP HEL113 SPR DAP PMC7279407__F2 Simplified diagram of the core element of the three unfolded protein response (UPR) signaling branches of the endoplasmic reticulum (ER) ATF4 EIF2A XBP1 PMC3701867__F1 Scheme depicting the interactive roles of interferon, Trim, and Socs molecules regulating the innate response in SjS-susceptible C57BL/6.NOD-Aec1Aec2 mice SOCS1 STAT3 TRIM5 TLE3 MAL IRF3 MTOR SOCS3 IL6 TRAF6 STAT1 TLR4 TRIM8 OAS1 OAS2 PMC4158832__F4 Planar cell polarity signaling in vertebrates DVL1 PTK7 PMC9663482__F9 Quercetin Suppresses Human Glioblastoma Migration and Invasion via GSK3B/Beta-catenin/ZEB1 Signaling Pathway GSK3B CTNNB1 PMC7755285__F11 Using WGCNA (weighted gene co-expression network analysis) to identify the hub genes of skin hair follicle development in fetus stage of Inner Mongolia cashmere goat KLF4 SLC3A2 F11R EPHA2 FZD10 LPCAT3 RPS6KA1 MTOR PLA2G2F DUSP2 BAMBI PLCG2 ATP6V1B1 UNC5B HSPA2 BMP4 GADD45B ALOX12 GNG4 SGK1 LIMK2 FZD7 EPHA1 LPIN3 EFNA3 CTNNBIP1 CDKN1A PPP2R1B SSH3 EPB41L4B SESN2 CLDN1 PMC3871910__F7 Proposed synergistic mechanisms for induction of mitotic cell death in endometrial cancer cells with mutant p53 WEE1 MYT1 PMC11538000__F1 Pyroptosis regulation by Salmonella effectors GSDMD NLRP3 MLKL DFNA5 RHO PMC4071401__F11 Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis NRP1 HIF1A VEGFA TWIST1 MAOA PMC6851023__F2 Pathways leading to IDO enzyme production and regulation AHR SOCS3 TNF PMC11538000__F3 Salmonella plasmid virulence factors and pyroptosis NLRC4 GSDMD NLRP3 PMC4731283__F1 Evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies BCL9 SOST RNF43 DKK1 APC ZNRF3 CCND1 CTNNB1 PMC11932863__F6 Targeting cell cycle arrest in breast cancer by phytochemicals from Caryto urens L. fruit ethyl acetate fraction: in silico and in vitro validation STAG2 TICRR CDC14B MAU2 CDC20 PCNA STAG1 SMC3 SMAD2 ESCO1 SMAD4 CDT1 MYT1 SKP2 CDK7 WAPAL SGOL1 MDM2 CD6 CDC2 DBF4 TRIP13 APC ESCO2 RAD21 KNL1 MTBP CDC45 DDX11 CDK2 NIPBL PMC9205109__F8 Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury GSDMD NLRP3 TXNIP PMC5492985__F2 Canonical Notch Signaling Pathway: Structural And Biochemical Insights Into Shape, Sugar, And Force KDM1B MLL2 KDM5A EZH2 RBPJ PMC9395613__F1 Advances in cell death mechanisms involved in viral myocarditis BAX FAS NLRP3 MTOR FADD CP PMC4505457__F10 Model for DAXX-mediated induction of tumorigenesis ULK1 PMC1559555__F1 GSH metabolic pathway GSTM1 HEL-S-75p GCLM GCLC GSTM5 NRF1 HEL-S-64p GPX1 HEL-75 PMC7573576__F4 Synthetic lethal pathway: multiple pathways GATA2 GFAP RHO TRAF6 NRF1 PMC7868569__F10 Chrysophanol-mediated suppression of the inflammatory response HDAC3 HMGB1 IL1B PMC7573576__F3 Synthetic lethal pathway: dual pathways BRCA1 PARP1 PMC7573576__F2 Synthetic lethal pathway: single pathway SMARCC1 ARID1A SMARCC2 ACTL6A ARID1B SMARCD1 SMARCA4 PMC7643807__F1B Activin Receptor-Ligand Trap for the Treatment of Beta-thalassemia: A Serendipitous Discovery GDF10 GDF3 GDF11 SMAD2 GDF1 PS1TP5BP1 PMC7015255__F6 Changes provoked by aerobic exercise training on microRNA‐1 downstream‐associated pathways in patients with chronic heart failure with reduced ejection fraction (HFrEF) PTEN MTOR MEF2C PMC2278039__F2 FIP200, a key signaling node to coordinately regulate various cellular processes RB1 TSC2 TSC1 MTOR CCND1 TRAF2 PMC7643807__F1A Activin Receptor-Ligand Trap for the Treatment of Beta-thalassemia: A Serendipitous Discovery GDF10 GDF3 GDF11 SMAD2 SMAD4 GDF1 PS1TP5BP1 PMC7378646__F2 Crosstalk between the Hippo-YAP1/TAZ pathway and Wnt signaling LATS1 LATS2 APC LRP5 LRP6 DVL2 ARHA YAP1 CTNNB1 PMC7378646__F1 Overview of Hippo-YAP1/TAZ pathway and its role in cardiac biology LATS1 LATS2 YAP1 PMC7378646__F4 Crosstalk between the Hippo-YAP1/TAZ pathway and GPCR signaling LATS1 LATS2 TRIO ARHA YAP1 PMC7378646__F3 Crosstalk between the Hippo-YAP1/TAZ pathway and BMP signaling LATS1 SMAD1 LATS2 DKFZp781O1323 SMAD4 YAP1 PMC4207610__F7 HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst CDX2 FGF7A SOX2 GATA6 PMC4442456__F1 Changes in the expression of cell cycle-related genes during MNV-1 infection TGFBI TGFB1 GSK3B SMAD4 PTTG1 MDM1 WEE1 CDK2 ATM EP300 GADD45A CDC25B YWHAG PMC6815541__F1 Probable mechanisms of the effects produced by lncRNAs on SCI KLF4 TCTN2 MAP2K4 TRIL TLR4 PMC4441984__F4 Scheme of the IL-11/STAT3/CDX2 pathway STAT3 CDX2 STAT1 BCL2 SOCS3 MTOR VEGFA PMC5889847__F3 CircRNAs function as ceRNAs in the regulation of apoptosis in tumor cells BAX APAF1 FADD PMC8495397__F3 Hippo pathway: a renewed insight in the craniofacial diseases and hard tissue remodeling LATS1 LATS2 IL13 RELA TRAF6 MYD88 PMC8129516__F1 Glycogen Synthase Kinase 3B Modulates the Inflammatory Response Activated by Bacteria, Viruses, and Parasites FZD5 STAT3 DVL1 GSK3B TLR9 TLR5 TNF CTNNB1 MYD88 STAT1 TLR4 WNT3 FZD1 PMC3635536__F5 Signaling Pathways in Schizophrenia: emerging targets and therapeutic strategies EGF NRG1 SOS1 GRB2 MTOR DISC1 PMC3140475__F5 Proteomic Biomarkers for Acute Interstitial Lung Disease in Gefitinib-Treated Japanese Lung Cancer Patients APOC3 SERPINC1 HEL-S-62p SERPINA3 SERPINA1 HRG C4A HEL-S-92n HPR HBD HP C4B_2 HBB RBP7 PMC4212952__F4 Network pathway analysis of differentially expressed genes in different subgroups of patients and controls HLA-DMB HEL-S-43 LGALS12 STAT4 HLA-DPB1 PITX2 PMC5992512__F2 Dynamic response of tumor cells to fluid shear stress CDC2 SMAD1 DKFZp781O1323 BMPR1A PMC7892237__F3 Autophagy: binding of growth factors to its receptor (tyrosine kinase) gets activated leads to the activation of PIP3K which phosphorylates PIP2 to PIP3 and recruits protein kinases PDK1 and AKT to inactivate TSC and RHEB TSC2 TSC1 TFEB PML BNIP3 MTOR PMC6059692__F4 Predicted regulatory networks affected by sinomenine treatment via Ingenuity®Pathway Analysis NUP155 TGFB1 MIA3 FGFR2 CST5 RBL1 ABCF1 RICTOR DOCK9 SSRP1 AHR COL12A1 AASS PMC7825621__F2 miRNA targeted network of cancer signaling including senescence CEBPE CCND3 SUZ12 EED PCNA CELF1 IL3 SMAD2 EZH2 CDKN2B RBBP7 KDM6B RBBP4 CCND2 AEBP2 RTN4 PMC11758815__F11 Cobalt signaling TRPM7 CBL PMC8222109__F1 Inflammatory Profile in a Canine Model of Hypothermic Circulatory Arrest CRP SOCS1 STAT3 TNFRSF1B NFKB2 MCL1 PIK3C2G MAPKAPK2 SOCS3 TRAF6 HRAS MAP3K7IP1 HEL-S-102 A2M GRB2 JAK1 MAP2K3 RRAS2 TRAF2 PMC3690356__F1 Calcium channels in T cells STIM1 APC PMC7924042__F7 Catalpol on AMPK pathway in alleviating DN GSDMD NLRP3 PMC7924042__F6 Molecular mechanism of catalpol in diabetic nephropathy TF BAX EGR1 PIM1 SELE PTEN PDK2 INS DAO IGF1 FOXO1 TFEB CASP3 MMP2 THBD BCL2 VCAM1 CDK4 PMC7924042__F9 Cardioprotective mechanism of catalpol in MI ATG101 CASP9 BAD ATG12 ULK1 CASP3 NRBF2 AMBRA1 ATG14 ATG5 PMC8304138__F2 Retinoids as Chemo-Preventive and Molecular-Targeted Anti-Cancer Therapies HEL111 CYP26A1 PMC11796038__F8 CTSB induces ferroptosis via SAT1-mediated lipid peroxidation, mitochondrial damage and MAPK signalling pathway activation GPX4 PMC7924042__F8 Cardioprotective mechanism of catalpol in diabetic cardiomyopathy BAX CASP3 PMC8945446__F2 Therapeutic Approaches Targeting Proteins in Tumor-Associated Macrophages and Their Applications in Cancers CDH2 MMP7 STAT3 CCL18 IL33 SOX2 IL1RL1 PTEN MMP9 MTOR BTN3A3 CCL2 SPP1 CTNNB1 PIGF LOX IGF1 HEL-S-68p PDPK1 TLR4 GPNMB MMP2 TRIB3 PMC4138085__F2 Transcriptional Profiling in Rat Hair Follicles following Simulated Blast Insult: A New Diagnostic Tool for Traumatic Brain Injury TBK1 LTA TIRAP IKBKE JAK3 IRAK1 MAPK9 MAPK8 TRAF6 IRAK4 MYD88 MAPK14 IFNG MAP2K6 MAP2K4 TICAM1 GHB2 MAP2K3 MAPK1 JUN TNFSF13 GHB3 FOS LTB NFKBIA MAP3K7 MAPK10 JAK1 IL12B TYK2 PMC9641982__F2 Innate immune mechanisms of mRNA vaccines STAT2 IRF9 IRF3 IRF7 TNF CXCL10 MYD88 STAT1 TLR3 GC TLR8 TLR7 JAK1 PMC3900522__F3 Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFBeta-Activated Kinase 1 Tyrosine Phosphorylation and NFKB Signaling in Multiple Myeloma and Bladder Cancer TRIM31 UBC SCNN1G SGK1 SLC38A3 SLC15A2 IKBKG BAMBI ACSL1 PDXP MGAT4A PSCA ZFAND5 PMC9442203__F8 Anti-proliferation and apoptosis-inducing effects of dihydroartemisinin on SH-SY5Y cells and metabolomic analysis C6 C7 HEL-S-62p C2 PMC4414490__F1 Activation and Function of Small GTPases Rho, Rac, and Cdc42 During Gastrulation CDC42 ARHA RAC1 DAAM1 PMC8247097__F1 Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer NLRC4 BAX NLRP1 HMGB1 IL10 BAD NLRP3 IL13 GZMA IL18 AIM2 IL1B PMC3037835__F5 Major pathways of lipid metabolism in yeast PLB1 GPD2 FEN1 PI3 CDS1 GPT2 PC IDI1 GHB3 MIP PSD2 PMC7715033__F1 Immune and molecular mechanisms of FSGS pathogenesis CLCF1 CD40 CD80 CCR2 PMC3461905__F2 Molecular pathogenesis of mantle cell lymphoma BAX SYK BTK FYN BCR GSK3B BCL2 ADAM10 LYN MDM2 MTOR NOTCH1 PMC5992512__F3 Various factors activated by fluid shear stress (FSS) can induce tumor cells metastasis VEGFB MTOR IGF2 IL1B PMC5852671__F3 Significance of selenium in cancer stem cell metabolism CITED2 ATM TIGAR SCO2 PMC10968114__F6 TSG-6 Inhibits the NFKB Signaling Pathway and Promotes the Odontogenic Differentiation of Dental Pulp Stem Cells via CD44 in an Inflammatory Environment CD44 DSPP RUNX2 PMC7970140__F2 Abnormal metabolic pathways ACLY GLS CS SLC16A3 GLUD1 PC MDH2 HEL-S-26 GOT2 FH ACO2 HEL-S-133P HK2 FASN LDHB HEL-S-30 PCK2 SDHA SDHB PDHA1 ME2 OGDH PFKP PGM2 HEL-S-162eP HEL-S-49 SUCLG2 DLD ENO1 ASNS PFKL HEL-S-87p PMC7663488__F3 Impaired regulation of lipid metabolism by AMPK in renal cells in obesity/diabetes FAS HMGCR CD36 PMC7935450__F1 CGAS-STING signaling pathway TBK1 CGAS IRF3 PMC8698071__F10 Resveratrol Relieved Acute Liver Damage in Ducks (Anas platyrhynchos) Induced by AFB1 via Modulation of Apoptosis and Nrf2 Signaling Pathways BAX KEAP1 GCLM NQO1 GCLC SIRT1 PMC5757132__F7 Proposed mechanisms of miR-146a in alleviating experimental autoimmune anterior uveitis (EAAU) STAT1 STAT4 TRAF6 PMC10384750__F1 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer MLST8 ATG3 SGK1 ULK1 RHO MTOR PMC11588768__F2 TGP treatment: A TGP regulates the Wnt/Beta-catenin signaling pathway to treat IgAVN KLF4 GPX4 MAF APP TNF PMC10985998__F8 Expression of genes in carbon, ATP, NADPH metabolism in C HEL107 RPE OGDH HEL-S-162eP PMC10384750__F3 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer RHEB TSC2 TSC1 PTEN IRS1 PMC10384750__F2 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer MLST8 RICTOR MTOR PMC6785663__F1 Classic view on the pathogenesis of celiac disease IL15 APC ELL PMC10384750__F6 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer RHEB TSC2 TSC1 PTEN MTOR IRS1 PMC8264592__F2 Local Anesthetic Lidocaine and Cancer: Insight Into Tumor Progression and Recurrence BAX MTOR SRC PMC7848718__F5 Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions KLF4 KLF2 CXCL12 TGFB1 ATP6V1A PIK3R3 PIK3CD CDKN2D GPX3 NOX4 TGFBR1 HMOX1 NR1B3 NQO1 KDR CEBPB CDK4 CCND3 VWF EGR1 SELE JUNB VEGFA ANGPT2 ID1 FGF2 CCL14 ATG9B NFKB1 RXRA PDGFRA DAPK2 VCAM1 PMC7916550__F5 Ingenuity Pathway Analysis downstream function prediction of the overlapping differentially expressed genes from the liver 3 h heat-control contrast and 4-week to 3 h control time contrast RBP5 SLIRP CPEB3 H6PD ZC3H12B RRM2 SGCG COL10A1 CDKN2B NMRK2 TGFBR2 LOXL2 CENPK NIP7 MICOS13 EPS15L1 TIMM10 MC5R GINS1 PIKFYVE PMC7848718__F4 Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions TF GSTT2 MGST1 GPX3 GPX1 NOX4 MAOA MAPK14 HMOX1 NOX3 NQO1 TXN2 HEL-S-44 UGT1A3 SP1 JUNB CYP1A1 FOS NFKB1 GCLC NFE2L2 XDH MAPK10 TXNRD2 CYBB HEL-75 PMC6544834__F1 Progress in the Management of Malignant Pleural Mesothelioma in 2017 BAP1 EZH2 PTEN MDM2 NF2 PMC9350707__F4 Immunomodulatory role of T helper cells in rheumatoid arthritis TNF IL1B PMC10492386__F10 EVs interacting with immune cells NLRP3 TLR4 MYD88 PMC7139827__F1 Endoplasmic reticulum (ER) signaling pathway and the ER–mitochondria pathway triggered by natural compounds ATF4 EIF2A TRAF2 PMC4358941__F2 Comparative Metabolic Analysis of CHO Cell Clones Obtained through Cell Engineering, for IgG Productivity, Growth and Cell Longevity HEL-S-133P MAL MDH2 CIT PMC6563521__F5 Upregulated genes in proteasome biosynthetic pathway at 24 h after inoculation using F IFNG RPE RPA3 RPN1 ARC POMP RPA1 RET PMC7429955__F7 LINC00675 activates androgen receptor axis signaling pathway to promote castration-resistant prostate cancer progression GATA2 MDM2 PMC5966875__F1 Synthesis and metabolism of common bile acids in human CDA HSD3B7 CYP27A1 PMC6523616__F8 A transcriptional and post-transcriptional regulatory system mediating the hepatic metabolic switch in chickens HEL-S-31 MSMO1 FOXO3A FASN GPT2 HDAC2 PMC11617665__F1 Metabolic signaling pathways modulated by PTP1B STAT3 PTEN IRS1 PMC8171523__F1 Wnt信号通路对软骨和软骨下骨双靶向调控及其在骨关节炎进展中的作用 APC RHO CTNNB1 PMC4424075__F3 Innate Immune Evasion by Filoviruses STAT2 IFNAR2 IFNAR1 JAK1 TYK2 PMC4424075__F2 Innate Immune Evasion by Filoviruses TBK1 MAVS TANK TRAF3 PMC7029263__F2 TRPV1-CNTF signaling cascade in PD STAT3 CNTF TRPV1 PMC7029263__F1 Wnt/Beta-catenin signaling cascade in Parkinson's disease APC GSK3B LRP5 LRP6 LEF1 CTNNB1 PMC3725164__F1 TGFB signaling pathway SMAD2 SKI PMC10218870__F1 Schematic diagram showing the main molecular targets of luteolin during the initial steps of the metastatic cascade CDH2 STAT3 BAX MDM2 MTOR SRC NOTCH1 PMC8899398__F3 Lactoferrin: A Nutraceutical with Activity against Colorectal Cancer BAX APAF1 PMC11036006__F13 Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation BAX PI3 PMC11273248__F1 Flavonoid compounds exerting protective effects against brain injury after ICH BAX NLRP3 NQO1 CASP3 TRAF6 PMC8168427__F7 Proposed mechanisms of ALDH2*2 to induce atrial fibrillation ALDH2 HEL-S-53e ALDH1A2 PMC4752785__F3 Scheme of the molecular mechanisms that systematic exposure to cigarette smoke can influence during carcinogenesis of the mammary gland EGFR BCL2 SRC PMC4752785__F2 Scheme of the molecular mechanisms that ethanol consumption can influence during carcinogenesis of the mammary gland AMPH TGFA F2 EGFR AREG PMC11273248__F2 Flavonoid compounds exerting protective effects on SAH BAX KLF2 NLRP3 NQO1 CASP3 SIRT1 PMC8671582__F2 Pathway network analysis of the significantly differentially expressed lncRNAs and mRNAs ALPL CAB39 F5 FLOT2 MTOR CARD6 TNF SLC22A4 NLRC4 MAPK14 RNASEH2B NAIP PYGL MAP2K6 PDGFC OPLAH SDHC PMC6581439__F6 Shown are the edges whose scores exceeded the threshold ; edges are labelled with their scores PRR5 PRR9 ELF4 ELF3 CAT56 PMC5328618__F8 Model for how APC mutations affect insulin-induced dynein movement toward MT minus ends APC GSK3B INS NDEL1 PMC5027283__F5 Oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway KDM4A HEL-S-26 DEPTOR PMC4439562__F4 GPCR (or GPR) signaling in the regulation of Beta-cell proliferation TCF7L2 PDX1 CCND2 EGFR BTC CDK2 GIP FOXA2 SIRT1 GIPR CTNNB1 PMC3481051__F3 The different main molecular pathways that are involved in neuronal stress response TF XPO5 VHL PMC4439562__F3 Cadherin and integrin signaling pathways TCF7L2 APC GSK3B CTNNB1 PMC4439562__F1 Cytokine and hormone signaling through JAK-STAT pathways PRLR TPH1 FOXM1 PRL GRB2 SH2B1 BCL6 PMC9687146__F5 Cisplatin Induces Senescent Lung Cancer Cell-Mediated Stemness Induction via GRP78/Akt-Dependent Mechanism CD44 ATR SOX2 CDK2 ATM PMC5137220__F1 Summary of genetic and pharmacological evidence implicating Wnt signaling in developmental cognitive disorders APC LRP5 LRP6 PTEN MTOR CTNNB1 PMC12078813__F8 TD formation EGF PMC3753830__F1 Schematic overview of signalling pathways and drug targets currently under investigation in CML research ALOX5 PML SMO MTOR CTNNB1 PMC6174864__F8 A working model illustrating HHcy-induced ER oxidative stress and inflammation in endothelial cells ERO1A VCAM1 GPX7 PMC6388721__F3 Simplified illustration of TXNIP role in presumptive pathways involved in endothelial dysfunction KLF2 NLRP3 TXNIP VCAM1 SRC PMC3078022__F1 Tumor heterogeneity and strategies to overcome kinase inhibitor resistance in cancer: Lessons from melanoma ARAF BRAF PMC4297928__F1 Simplified pathophysiology of reactive oxygen species (ROS) and etheno-DNA adduct formation LOX COX2 MPO PMC8041338__F1 Imipridones in targeting mitochondrial metabolism in cancer cells BAX CLPP BCL2 ATF4 CLPX PMC5451507__F2 Congenital heart defect BioCore (CHD-BioCore): strategy and frame work EGFR GSKIP PTEN SRC IMPACT PMC5532733__F2 Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation GGPS1 EGR1 HMGCR PMC2174972__F7 The Viral Oncoprotein LMP1 Exploits TRADD for Signaling by Masking Its Apoptotic Activity LTB TRADD TRAF6 PMC8630009__F6 Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology MAX TRADD SELE LIF HEL-S-11 TNF FOS FADD PMC2824905__F2 IFITM Proteins Mediate the Innate Immune Response to Influenza A H1N1 Virus, West Nile Virus and Dengue Virus SNRPD2 RAB30 RPS15A FUS KRTCAP2 PIGH NDUFB11 RPS14 PRPF8 SNRPD3 FHOD3 EIF2AK4 EIF3F SAMM50 SNRPB NDUFB1 CWC22 PPAN CNTN5 CRADD LSM2 SRP54 MOCS3 SIGLEC9 ESAM PSMB3 MPZL1 COPZ1 PLCH2 SLC35A1 AQR RPS20 THRSP ATP8 PRPF31 PCSK5 SART1 EIF3B PCDHGA1 ATP6V0B SLU7 B4GALT2 PRCC SCYL3 CALCOCO2 PRSS8 NDUFB8 RAB10 SF3B1 STAC3 NDUFB9 BACE1 PIGT RPS16 RBM34 YTHDC1 EIF3S3 ATP6V0C COPB2 IFITM3 CEACAM7 DMD NUP107 CADM2 RPS5 COPS8 B3GALT2 NUTF2 ADAT1 RAVER1 NR1C1 GSK3A RPL13A TGS1 PHYHIP PFKL NUP98 PMC8630009__F8 Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology C2 HP DAO PMC7285601__F1 Simplified schematic of pyrimidine nucleotide synthesis showing enzymes targeted for cancer therapy CAD CTPS2 CDA SLC29A3 SLC29A1 SLC28A3 DPYD DCTD UMPS DHODH PMC4155023__F3 Growth factor- and cytokine-regulated pathways are activated during liver regeneration STAT3 HEL-S-62p PLG SOCS3 CCND1 UNK PMC6381212__F8 Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma BAX MTOR PMC3356053__F10 Most significant canonical pathway from this study MAX CRK OCEL1 GRB2 MYC PMC7878670__F2 IGF-1R trafficking routes and signaling to the mitochondria and from the Golgi and the Nucleus RANBP2 SNAI2 JUN IGF1 GSK3B BNIP3 IGF1R CCND1 LEF1 AXIN2 IRS1 PMC7415793__F4 Treg in cardiomyocyte regeneration CCL24 CST7 FGL2 TNFSF11 AREG IGF2 PMC8836222__F10 Comparative Transcriptome Analysis Reveals Mechanisms of Folate Accumulation in Maize Grains GGH FPGS DHPS PMC3057147__F1 Top associated network functions for miR-141 and miR-200c DIPLA1 DKFZp761E1322 PMC8541208__F5 Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis BAX FAS TRADD MCL1 TNF TRAF2 FADD PMC8541208__F4 Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis RBX1 ZER1 ELOC PMC5009010__F9 Schematic signal transduction network representing the effect of chronic alcohol on protein balance in eWAT RHEB EEF2K TSC2 EIF4B TSC1 ATG12 ULK1 EEF2 ATG5 EIF4E PMC6585021__F4 The molecular mechanism of OM antifibrogenic effects.OM could attenuate HSCs activation induced by TGFB1 in vitro by down-regulating the expression of miR-195 and up-regulating Smad7 SMAD2 SMAD4 PMC8850260__F8 Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NFKB/HPSE1 Signaling Pathway During Inflammation TLR4 VCAM1 SDC1 PMC6515079__F10 Network analysis of proteome datasets in M2 polarized (vs HEL-S-72p KRT10 CD59 MSH3 RPSA HES6 KHSRP HOOK1 NONO CNR2 EIF4A1 HEL-S-87p HNRNPK HNRNPC NACA YWHAG PMC5972417__F7 The FA pathway and SPR-5 cooperate in DNA repair and regulation of histone demethylation FANCD2 FANCM FAN1 PMC5355638__F2 Mechanisms of RSV T-cell interference as a potential immune evasion strategy FAS MTOR PMC7976584__F6 MiR-362-driven TGFB/SMAD signaling modulation of cell migration and invasion: a proposed scheme SNAI1 SMAD2 SMAD4 DACH1 PMC2469272__F2 LPS signaling [modified from O’Neill and Bowie () with permission] TLR4 MAL CD14 IRF3 IRF7 TRAF3 TRAF6 MYD88 PMC7737291__F1 Genes found altered in Central Carbon Metabolism (CCM) pathway in gingivo-buccal oral cancer PIR GLA PTH CIT PMC4941333__F9 Aquaporin 3 promotes the stem-like properties of gastric cancer cells via Wnt/GSK-3B/Beta-catenin pathway CD44 AQP3 GSK3B CTNNB1 PMC6055056__F4 FoxO signaling pathway STAT3 KLF2 BNIP3 IL7R PTEN INS SKP2 ATG12 CDK2 ATM GOPC NLK GHB2 MDM2 PMC6055056__F5 Signaling pathways involved in susceptibility to Salmonella enteritidis infection SOCS1 TNFRSF11A EGFR NGFR PDGFA PIK3CD BMP7 TNFRSF25 IL10RA HOMER3 IRS1 PIAS2 INSR IL13RA1 IKBKB IL18 CREBBP CXCR4 BCL6 CCND1 IL10RB SETD7 PMC7110972__F7 Proposed rES/ID1/TSP-1 signaling pathway CD36 ID1 CD47 PMC3889250__F1 The BDNF signaling network JUN ALPL NFATC4 NCF2 APC NTRK3 MTOR NGF SHC4 ADAM17 RELA NFKBIA EEF2 PTPRE SIRPA SRC SHC3 PMC8257821__F6 PTEN Lipid Phosphatase Activity Enhances Dengue Virus Production through Akt/FoxO1/Maf1 Signaling MAF1 FASN PTEN PMC4172469__F7 Estrogen Regulation of microRNAs, Target Genes, and microRNA Expression Associated with Vitellogenesis in the Zebrafish STAG2 PCNA STAG1 SMAD2 GSK3B SMAD4 MYT1 SKP2 CDK6 CDK7 E2F4 CDC45 PI3 CDK2 MDM2 CDK4 PMC7599606__F2 An integrative view of glutamine metabolism GLS FASN MAL HEL-S-26 PMC8728518__F2 PLK1 inhibition-based combination therapies for cancer management STAT3 BRD4 EGFR MTOR SRC PLK1 CRBN PMC4393358__F3 FGF signaling pathways ETV5 TSC2 CBL SHB FOXO1 CRKL ETV4 GRB2 GRB14 PMC3759480__F3 Wnt/Beta-catenin signaling was activated in gemcitabine resistant NSCLC cell lines CD44 JUN DKK1 TCF4 MDM2 MYC PMC5336655__F4 Example of a visualisation of a significant pathway using the SetRank package PML CD14 KIT KRAS SPI1 MPO WT1 RARA CEBPA RUNX1 CBFB CD33 NRAS PMC4393358__F1 FGF and FGFR families TK1 IL1B PMC5593677__F2 Promising landscape for regulating macrophage polarization: epigenetic viewpoint CXCL12 KLF6 EBP SMAD2 IRAK1 IRAK2 TRAF6 HDAC1 STAT1 INHBA PKNOX1 JAK1 KLF13 PMC9671555__F4 Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease SLC6A19 ACE2 PMC9441790__F3 Primary cilium in kidney development, function and disease INVS APC GSK3B CTNNB1 PMC6050292__F7 Dynamics of S1P- and ceramide-synthesis pathway STAT3 UGCG ABCC1 ACER1 SGPL1 SPHK1 DEGS1 SGMS2 DEGS2 SGPP2 SMPD2 MAPK3 CERS6 PLPP3 ASAH2 SMPD4 SPNS2 ORMDL2 ORMDL3 SPHK2 SGPP1 ABCG2 MAPK1 CERS3 CERS5 CERK ORMDL1 GBA2 CERS1 CERS2 IL6 SPP1 PLPP2 PLPP1 ACER3 PMC9441790__F2 Primary cilium in kidney development, function and disease PAX8 WNT9B WNT4 FGF8 CTNNB1 PMC7468582__F9 WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation STAT3 HEL-S-52 PMC8305593__F1 An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells IFNG TH IL4 BCL2 STAT4 MDM2 LCK WDR5 PMC8992454__F1 Barriers to achieving a cure in lymphoma ZAP70 SYK PIK3CA CD79A SLA TNFAIP3 SOS1 MCL1 CARD11 PIK3CD PTEN MTOR TRAF3 TRAF6 PRKCB MYD88 BCL2L1 PLCG1 BTK BCL10 BCR PDPK1 NFKBIE DGKZ JUN INPP5D PIK3AP1 CD19 VAV1 FOS NFKBID ZC3H12A IKBKB NFKBIA BCL2 LYN GRB2 TRAF2 LCK PMC10971254__F10 Binding of IL-33 to its receptor induces the MyD88/IRAK1/IRAK4/TRAF6/NFKB- dependent signaling pathway and the TRAF6/MAPK/AP-1-dependent signaling pathway IL33 TRAF6 MYD88 PMC2909379__F3 Hox Genes and Regional Patterning of the Vertebrate Body Plan CDX2 HOXC13 PMC9578855__F7 Eucommia ulmoides Oliver's Multitarget Mechanism for Treatment of Ankylosing Spondylitis: A Study Based on Network Pharmacology and Molecular Docking tal-1 PMC10498433__F8 Lactate-induced oxidative stress HCAR1 CCL3 HK2 MMP3 NOX4 PMC10960062__F7 Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity ACLY TF BRD4 PPARG HEL60 NR1D1 CS RORA HSF1 PBRM1 HEL-S-32 MDH2 GABPA TBP CEBPB GPS2 CREB1 FOXA1 DHTKD1 ACO2 NR3C1 PCK2 SDHA RAD21 CEBPA ONECUT1 NR2A1 SUCLG2 CREBBP EP300 TAF3 PMC10960062__F6 Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity TF STAG2 BRD4 PPARG NR1D1 XBP1 RORA PROX1 GCK TBP GPS2 PKLR GPT AGXT2 FOXA1 HEL-S-133P GPT2 HEL-S-30 NELFA NCOR2 ALDOB AGXT HEL-S-68p HEL-S-49 RXRA FBP1 CREBBP EP300 PFKL HEL-S-87p TAF3 PMC10960062__F5 Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity TF FOXA1 PPARG BRD4 NR1D1 NELFA XBP1 NR3C1 RAD21 CEBPA ONECUT1 NR2A1 RXRA CREBBP EP300 CEBPB GPS2 PMC4362638__F4 IPA-inferred Sertoli cell – Sertoli cell junction signalling pathway CDC42 CGN MTMR2 A2M ATF2 PALS2 SYMPK PMC7001271__F1 GPI biosynthesis pathway PIGP PIGC GPAA1 PIGH DPM2 PIGV PIGU PGAP1 PIGT PIGO PGAP2 PGAP3 PIGF PIGN PIGW PIGA PIGY PIGX PIGB PIGL PIGK PIGS PIGM MPPE1 PMC10527779__F3 Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View PINK1 SIGMAR1 PICALM PMC6073722__F3 APC activity is decreased under nutrient conditions, and increased when nutrients are limiting HEL-S-92n CDC23 APC CDC27 SIRT2 CDC34 SKP2 PMC8969394__F1 Biosynthetic pathways of triterpenoids and strategies to improve their Biosynthetic Efficiency IPP MVP MVD MVK PMC8619966__F1 Hedgehog Pathway Inhibitors against Tumor Microenvironment IL10 CCL28 SUFU IL13 IL18 IL4 SMO IL6 PMC4588730__F2 Functions of FGF19 and the corresponding mechanisms FGF8A FGFR4 FGFR1 PMC3408431__F8 RhoA GTPase Switch Controls Cx43-Hemichannel Activity through the Contractile System HEL-S-62p ARHA RHO PMC6111862__F6 Model of ADAM‐17/EGFR signalling axis activation induced by deoxycholic acid in intestinal carcinogenesis ADAM17 EGFR AREG PMC4053266__F3 Integrative pathway analysis PAX3 TEC ARHH ICAM3 DCT BCL2 VCAM1 ARHA SOX10 CXCR4 PECAM1 PMC5473031__F6 Gestational exposure to sidestream (secondhand) cigarette smoke promotes transgenerational epigenetic transmission of exacerbated allergic asthma and bronchopulmonary dysplasia BCL2 RUNX3 PMC4309199__F2 Toll-like receptors and IL-1 receptor family signaling pathways TLR3 TLR4 TLR5 TLR7 MYD88 PMC2576557__F10 Schematic diagram showing the pathway involved in high glucose- and high insulin-induced extracellular matrix protein synthesis mediated by GSK3B and eIF2BE GSK3B EEF2 MTOR EIF4E PMC11355432__F7 Proposed model for the protective mechanism of CPE against CKD-induced HAS DBP PC ACE2 PMC5615778__F2 Working model for sensing of glucose availability by AMPK and its potential interactions with the mTORC1 signalling pathway at the lysosome RHEB TSC2 TSC1 PMC8276045__F2 T Cell Specificity: A Great Challenge in Chagas Disease CD40 TH CD2 APC HLA-A PMC3807489__F8 Proposed metabolic models for syntrophic growth of D POR HEL-S-133P PMC2671566__F7 Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor MUSK LRP4 LAT PMC3044050__F6 Spry2 and Spry2Y55F function in the context of EC MAPK signaling SPRY2 RAF1 SOS1 GRB2 PMC4100437__F1 Hypothetical model of chemoresistance in human ovarian cancer cells BAX FAS CDK6 MDM2 CDK4 PMC6103457__F1 Cilia and intraflagellar transport IFT27 IFT46 IFT140 IFT172 IFT74 IFT80 IFT52 IFT22 IFT43 IFT57 IFT81 IFT20 IFT25 IFT56 PMC7869012__F6 Bioinformatics analysis of sevoflurane altered lncRNA-related pathways based on the dysregulated lncRNA co-expressed dysregulated mRNAs using ingenuity pathway analysis (IPA) software DUSP5 ST8SIA4 JUN SLC40A1 SCN11A LEP PIK3R1 NR4A3 PIANP S1PR4 EGR4 GFAP ALDOB NR3A2 SFRS5 SRXN1 TNFRSF11B KBTBD2 PMC8416371__F10 Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis FRY KY INA PMC3820656__F1 Scheme of the endothelial angiopoietin (Angpt)/Tie2 system highlighting fundamental signalling pathways ANGPT1 RHO ANGPT2 RAC1 PMC7690450__F2 Curcumin, as a multitarget compound, induces apoptosis and cell cycle arrest in neuroblastoma (NB) cells through the modulation of PTEN–Akt, NFKB, and p53 signaling; mitochondrial dysfunction; and caspase activation BAD FAS FOXO3A PTEN PMC5693401__F3 Signaling pathway network model: Panel (a) presents the biological network describing the mTOR pathway (based on Fig EGFR PTEN MTOR EIF4E PMC7412400__F7 Mechanistic map depicting the potential role of the HDAC1/LSD1/SESN2 pathway in VC in CRF HDAC11 MTOR SESN2 PMC8608878__F6 Schematic presentation of the circKDM4C-regulated pathway in BCa cells CDH2 KDM4C PMC8576090__F3 Bioprospecting of microalgae metabolites against cytokine storm syndrome during COVID-19 LOX ACE2 MYD88 PMC5117516__F1 Viral sensing pathways that trigger host immune responses TBK1 MAVS STAT2 IRF9 IRAK1 IRF3 IRF7 IL6 TRAF3 TRAF6 MYD88 STAT1 NLRP3 IL18 NOD2 JAK1 TYK2 PMC3157296__F8 Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth FKBP5 JUN EGR1 EZH2 PTEN MTOR PMC10648981__F3 Jasmonates in coordinating secondary with primary metabolism IPP LOX HEL-S-70p PMC11674460__F2 The molecular mechanism underlying the pleiotropic anticancer activity of As2O3 against GBM cells BAX ATR ATM XBP1 NOTCH1 XPC PMC6348685__F4 Putative genes and their expression patterns in the biosynthetic pathway of astaxanthin in H DHDDS FDPS PMC11674460__F6 The molecular mechanism underlying the pleiotropic anticancer activity of tetrandrine against GBM cells and GSCs BAX PCNA EGFR CCND1 PMC6062504__F6 DLX1/DLX2 may influence MAPT via WNT or GABA signaling pathway CUX2 DLX1 GABRA5 WNT1 GABRB3 DLX2 WNT10A SLIT1 LHX8 PMC7175771__F1 Autophagy pathway ATG101 ATG10 ATG3 ATG16L1 ATG12 ULK1 MTOR ATG5 DEPTOR PMC3169508__F3 Pathway interactions and detailed network visualization for the interactions with three apoptosis related pathways for the comparison between HF and LF diet at t = 0 JUP FAS SOS1 MAPRE1 MAPKAPK2 GSK3B PRKCZ IRAK1 PLK4 TUBB KRAS PRKCH MAPK14 CEP57 MAP3K1 CHUK NRAS CTRB1 PRKAR1A PMC7737552__F1 Huaier induces apoptosis by upregulating p53 expression MTDH GSK3B EZH2 PTEN MTOR CTNNB1 PMC11987792__F3 Exosome-mediated DOX resistance in BC RNF11 PIK3R1 PTEN NOTCH1 PMC3169508__F2 An indirect interaction between the Axon Guidance and Insulin Signaling pathways in the network for the comparison between HF and LF diet at t = 0 CDC42 TSC2 TSC1 FOXO1 GSK3B FES PMC8545927__F2 Elucidate multidimensionality of type 1 diabetes mellitus heterogeneity by multifaceted information LTBP1 RFC1 PXN PSG1 AIRE INS CTSG IFNG TAGAP HLA-DRA REN HLA-G tmp_locus_29 LNPEP BTC FOXP3 G6PC2 CASP2 SOX13 HLA-DQB2 IRGM PTPRN STK24 CMAS IRS4 MICA BMX GNAL IL6 PTPRN2 SLK PTPN22 AGTR2 ENG PSMD9 FABP2 GCKR PMC8759629__F1 MICROGLIA AS THERAPEUTIC TARGETS AFTER NEUROLOGICAL INJURY: Strategy for Cell Therapy IL13 TNF PMC9046545__F10 Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review BTK FGFR1 FGFR3 FGFR2 PMC11987792__F5 Exosome-mediated platinum drug resistance in breast cancer PIMREG PGP NLRP3 PTEN BRCC3 PMC6589740__F1 Diagram of the proteins and precursor/product sugars involved with guanosine diphosphate-fucose synthesis, Golgi transport and attachment of core fucose to N-linked glycoproteins SLC35C1 FUT8 FPGT GMDS PMC7737552__F2 Huaier inhibits cell proliferation and metastasis by upregulating DARC and downregulating its ligands CDH2 BMI1 YAP1 PMC7895513__F7 Regulatory effects of PCSK9 on endothelial cell pyroptosis by increasing ROS production via the inhibition of UQCRC1 UQCRC1 PCSK9 GSDMD NLRP3 IL1B PMC4669196__F3 Proteomics Perspective on Viral DNA Sensors in Host Defense and Viral Immune Evasion Mechanisms CGAS MAVS DHX36 TLR9 DDX41 AIM2 IFI16 IRF3 IL1B MYD88 PMC9585259__F2 Changes in the urinary proteome before and after quadrivalent influenza vaccine and COVID-19 vaccination CDC42 VWF EGF HEL-S-2 GPC1 UBC HEL-S-62p CFD APOE ARHA CLEC3B ORM2 GNB1 AHSG ITGAM APOA4 ACTN4 CLU HEL-S-87p KIN GAS1 ITIH4 PMC9403860__F1 How the crosstalk between innate immune sensors and metabolic pathways affect the outcome of Brucella abortus infection? AIM2 HIF1A MTOR IL1B MYD88 PMC5175149__F7 Infergen Stimulated Macrophages Restrict Mycobacterium tuberculosis Growth by Autophagy and Release of Nitric Oxide STAT3 IFNAR2 IFNAR1 JAK1 TYK2 PMC11242587__F1 Association of type 2 diabetes mellitus with cancer, for example, pancreatic cancer STAT3 IGF1 INSR MTOR PMC10507626__F2 Molecular mechanism of inducing cognitive impairment in OSA patients through intermittent hypoxia (IH) NLRP3 BACE1 MYD88 PMC5268776__F12 Differential Feedback Regulation of Δ4-3-Oxosteroid 5Beta-Reductase Expression by Bile Acids AKR1D1 CYP8B1 CYP7A1 SI PMC12100627__F9 Mechanism by which rSPD promotes in vitro replication of IBRV STAT2 CCL3 IRF9 IFIT1 S100A8 TLR9 IRAK1 IRAK2 RSAD2 TRAF6 MYD88 STAT1 TLR4 MX1 ISG15 TYK2 OAS2 IL1B PMC9496435__F3 Targeted genes in the mitogen‐activated protein kinase pathway (MAPK) TF SHF MAK EVI1 ACD PMC7320879__F1 Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease RORC TLR4 FOXP3 PMC3173146__F8 Summary and working model EGFR SP110 SRC PMC7222183__F1 Main mechanisms in ferroptosis GPX4 LPCAT3 FACL4 ALOX15 HEL-S-64p HEL-75 ADA PMC8597024__F6 Identification of miR-499a-5p as a Potential Novel Biomarker for Risk Stratification in Endometrial Cancer APC GSK3B CTNNB1 PMC4404917__F1 Synthesis of EPA, DPA and DHA from ALA HSD17B4 ACOX1 ELOVL2 HEL-S-5 FADS2 ELOVL1 FADS1 PMC12000086__F5 Synthesis pathways of 16 esters and alcohols PDC ACD HTT PMC7222183__F3 Charcot-Marie-Tooth disease (CMT) pathways related to oxidative stress MFN2 GDAP1 HSPB8 PMC5915042__F1 Scheme describing the mechanism of lethal autophagy induced by DDA NR1H2 EBP TFEB PMC5808733__F1G Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission STAT1 STAT2 IFNAR2 IRF9 IFNAR1 JAK1 TYK2 PMC3340193__F8 Scheme to explain the increased production of HA in fro/fro (NSMase2−/−) mouse fibroblasts HAS2 PTEN MTOR PMC5640978__F4 Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection CCL3 CCL4 CCL2 TNF PMC7311766__F2 DAMP/PAMP PPR pathway manipulation GIT2 SYK NLRP3 MAL GSK3B IRF1 MYD88 PMC6858840__F1 NAD+ biosynthetic and degradative enzymes NRK NAPRT SARM1 HEL-S-90n NAMPT PMC2922498__F2 Schematic for DSB repair by HR and NHEJ pathways RAD51C RAD51 BRCA1 PALB2 POLN PMC7592369__F4 Role of HIFA on fatty acids metabolism during cancer progression via epigenetic regulation FAS PTEN CS PMC7592369__F1 Canonical and non-canonical regulation of HIF signaling EPO PTEN GRB2 MTOR CCND1 PMC6282138__F6 Proposed mechanisms of lipoprotein uptake and Fluocinolone acetonide effects on inflammation and lipid accumulation in THP-1 derived foam cells CD36 GC GCGR PMC10985004__F5 Construction of signaling pathway between DEPs CCDC39 PPARG RSPH9 HMGB1 TGFB1 ACADSB GPX4 CREM CYC1 DNALI1 MTOR TRPM8 RAB21 STAT1 ACAT2 HEL-S-102 ALOX12 SMCP ASNS FABP9 CREB1 LMNA PMC8472822__F1 Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases IPP STEAP3 GPX4 LPCAT3 FACL4 CP ADA PMC8055737__F1 ESCAPE-NA1 Trial Brings Hope of Neuroprotective Drugs for Acute Ischemic Stroke: Highlights of the Phase 3 Clinical Trial on Nerinetide PLG PMC10379230__F5 Isoflurane Anesthesia’s Impact on Gene Expression Patterns of Rat Brains in an Ischemic Stroke Model RANBP2 LRRC58 SOST GPR22 SULT1A1 ZBTB41 BCL6B EGR2 WFS1 APOLD1 PMC9072078__F7 Antineuroinflammatory Effect of Amburana cearensis and Its Molecules Coumarin and Amburoside A by Inhibiting the MAPK Signaling Pathway in LPS-Activated BV-2 Microglial Cells CSA2 TRAF6 MYD88 PMC5654406__F1 Sequence Evidence for the Presence of Two Tetrapyrrole Pathways in Euglena gracilis CPOX FECH UROD UROS PMC2519541__F2 Integration of the AinS-AinR and LuxI-LuxR quorum sensory pathways C6 MED8 PMC4362662__F7 A hypothetical illustration for the mechanism of resveratrol on the EMT of colorectal cancer SMAD2 PMC10728906__F4 Inflammatory activation of astrocytes and microglia by Alpha-Syn and phenotypic switching between astrocytes and microglia NLRP3 CX3CL1 CCL5 MTOR TNF MYD88 PMC6803543__F3 Ras signaling pathway shown as an interacting network CDC42 ZAP70 SYK CREB3 SHC1 LAT PTEN ATF2 SHC2 RHO FYN CDK6 BCR RASA2 ATF4 SHC3 CREB1 CDK4 GDNF CRKL GNAL RASA3 RAB5A RIN1 GRB2 RET LCK PMC4530548__F1 Antiviral Defense Mechanisms in Honey Bees AGO2 C2 UNC80 REL FADD PMC7460696__F1 Lysophosphatidate (LPA) signaling pathway LPA RHO PMC9614042__F10 LXR agonist inhibits inflammation through regulating MyD88 mRNA alternative splicing SF3A1 TLR4 IRAK4 MYD88 PMC6961113__F1 B-vitamins, one carbon metabolism and related pathways CBL SHMT1 CTH MTRR MTR PMC3905285__F4 Possible pathways for lipoic acid attachment to mitochondrial Alpha-ketodehydrogenase apoenzymes NFU1 LIPT2 LIPT1 BOLA3 LIAS PMC5968387__F8 Signaling pathways that are postulated to upregulate the expression of A20 and then inhibit inflammatory mediators in macrophages induced by M protein following GAS infection IL16 TRAF6 IL1B MYD88 PMC6185797__F1 GSK-3 regulated signaling pathways and splicing factor phosphorylation APC LRP5 LRP6 CTNNB1 PMC6803282__F3 Mechanistic network analysis predicted by Ingenuity Pathway Analysis C6 CXCL12 MMP14 UBE2C HMMR SDC4 HIF1A CXCL8 XBP1 CTNNB1 FGFR2 HEL-S-99n PLAT INHBA HEL-S-2a DCN CREB1 CSF2 HEL-S-89n MMP9 TNF ANGPT2 SPP1 TCF7L2 PTHLH HEL-S-125m HEL-S-162eP TNFSF10 PMC9524788__F1 CGAS-STING Pathway - Implications for Systemic Lupus Erythematosus CDC2 TBK1 CGAS IRF3 SLC19A1 PMC11760447__F1 Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application OXCT1 ACAT1 HMGCL CS PMC11847347__F6 Cancer-secreted exosomal miR-1825 induces angiogenesis to promote colorectal cancer metastasis SMAD2 ING1 PMC12060536__F10 Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury DCD CDKN2A LONP1 NPS ATF5 CDKN1A GDF15 CLPP MMP9 SIRT1 PMC7692384__F10 Neurofibromin regulation of the growth factor-controlled Ras/PI3K signaling pathway RHEB TSC2 NF1 GRB2 MTOR PMC6021760__F5 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer AURKA ATR PRKD1 ULK1 NEK2 MTOR PLK1 NUAK1 PDPK1 CSK ATM LYN CDK4 PMC3431075__F1 NFKB members and NFKB signaling CD40 BCR RELA RELB PMC8934560__F3 Nourishing Better Vision: The ARVO 2021 Mildred Weisenfeld Award Lecture ELOVL4 ELOVL3 ELOVL2 tmp_locus_29 ELOVL1 ELOVL5 PMC5187800__F8 Schematic representation of metformin roles in TGFB1-induced epithelial-to-mesenchymal transition in cervical carcinoma cells STAT3 MTOR PMC3705591__F2 Common signaling pathway for Toll/IL-1R (TIR) family members IL33 IRAK2 TRAF6 MYD88 PMC8880046__F2 Adaptive Immune Responses, Immune Escape and Immune-Mediated Pathogenesis during HDV Infection STAT3 CD69 PMC9379395__F8 Nitroxoline suppresses metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway EGR1 PMC9157490__F3 Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha LOX TLR4 HEL-S-69p PMC8436617__F3 N6-Methyladenosine in Cancer Immunotherapy: An Undervalued Therapeutic Target CD40 STAT3 CD80 TIRAP METTL14 METTL3 PMC8950598__F1 Signaling Pathway of TNF Receptors: Linking Animal Models of Renal Disease to Human CKD RIPK3 COMP TRADD C2 MLKL TAB3 TRAF1 REL TRAF2 FADD PMC4013670__F6 Schematic describing the proposed anti-inflammatory response resulting from resveratrol treatment and its effects on TLR4 following stimulation of chondrocytes with IL-1B TLR4 TRAF6 IL1B MYD88 PMC4480196__F1 MTOR-mediated T cell activation and lineage specification RHEB TSC2 TSC1 HEL-S-162eP FOXP3 PMC6311899__F3 Result of newborn mouse lens epithelial cell MYB RAF1 CELSR1 RFX2 BMPR1A FGFR2 FZD8 FZD3 CDH6 FGFR1 ETV4 KREMEN1 SRC CDH2 EFNB2 CACNA1C PLXNA2 E2F8 FZD2 LRP5 LRP6 PAX6 NOTCH2 tal-1 FZD4 ADCY1 SDC2 GLI3 PTPRM FZD5 RFX3 RELB PLXNB1 RYK MTOR TGFBR1 GPC5 F2R INSR ZHX2 CHUK TACR1 FZD1 NOTCH3 GPR49 MLXIP GPC1 ITGA4 SGK1 SOX2 FZD7 SDC1 NR3C2 S1PR3 HIF3A ITGB1 APCDD1 PDGFRA NEO1 PTPRB NLK CSPG4 LEF1 ZIC2 PMC4480196__F2 Pharmacologically targetable regulatory checkpoints of the mTOR pathway RHEB TSC2 TSC1 PTEN HIF1A PMC6621796__F11 Schematic drawing to illustrate JAK-STAT signaling pathway GFAP IRF9 MCL1 PMC7759999__F1 Opsonized epithelial apoptotic particles and ICs containing nuclear autoantigens bind to plasmacytoid DCs (pDCs) and RF B cells via TLRs and Fc receptors, respectively BCR GC PDC PMC3464089__F2 Aberrant activation of the MAPK signaling pathway in papillary thyroid tumor cells NTRK1 BRAF RET PMC7497849__F3 CCL5-VEGF-A signaling pathway in BEV treatment CCL3 CCR5 VEGFA KLF13 PMC11921692__F4 USPs and p53 signaling pathway USP36 USP4 USP11 USP22 HIF1A MDM2 USP9X CYLD RBM28 PMC11921692__F3 USPs and Nrf2 signaling pathway USP25 RBX1 USP15 KEAP1 USP11 USP29 USP16 PMC9240190__F6 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy RYR2 MCU MCUB PMC11921692__F2 USPs and TGFB signaling pathway TRAF4 SMURF1 USP15 USP4 SMAD2 USP11 SMAD4 SMURF2 USP9X TRAF6 CYLD USP26 PMC9240190__F5 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy SMAD2 SMAD4 ADAM10 RHO PMC11921692__F1 USPs and NFKB signaling pathway USP25 TRADD USP19 RELB USP11 IRAK1 TRAF3 TRAF6 IRAK4 MYD88 USP15 USP4 USP18 RIPK1 TRAF2 CYLD PMC9240190__F4 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy NLRP3 KEAP1 TLR4 MAF TRAF6 MYD88 PMC4798945__F7 A model of the tumor suppressive functions of TGM2 in HMECTERT/ST/ER-RasV12 cells ATG12 CDKN1A SQSTM1 ATG5 PMC9240190__F3 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy RHEB SIRT3 TSC2 NR1C1 TSC1 CD36 ULK1 PMC6266917__F3 Systemic effects of increased adiposity on EC progression ANGPT1 IGF1 LIF IL1B PMC9240190__F2 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy GSK3B PTEN IRS1 PMC6266917__F2 Contributions of activated/recruited stromal cells in endometrial cancer (EC) progression EMP2 HGF CCL5 CXCR4 CCND1 IL1B PMC7773816__F3 Effect of amino acids and their derivatives on T cell signaling ZAP70 LAT ATF4 MYC LCK PMC10907749__F2 Antagonizing the host immune response by T. gondii SOCS1 STAT3 STAT1 SOCS3 PMC7773816__F1 Role of amino acids and amino-acid catabolizing enzymes in T-cell activation GC JAK3 AHR PMC10907749__F1 Host immune responses to T. gondii infection UNC93B1 TLR4 TLR9 TLR7 IRF8 MYD88 PMC10907749__F4 T. gondii antigen alters the signaling pathway of the host cell IFNG STAT3 NLRP3 CCR5 TLR4 SOCS2 ARG1 PMC3887453__F2 Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress MEF2B JUNB NOX4 PMC8123284__F3 Alteration of Iron Concentration in Alzheimer’s Disease as a Possible Diagnostic Biomarker Unveiling Ferroptosis TF SLC3A2 GPX4 SLC7A11 PMC8123284__F2 Alteration of Iron Concentration in Alzheimer’s Disease as a Possible Diagnostic Biomarker Unveiling Ferroptosis TF FES CP PMC10854812__F10 Selected agents targeting the Fyn/CD133/PI3K/Akt/mTOR pathway RHEB TSC2 FYN PTEN MTOR PMC4826221__F9 Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells CDC2 ATR ATM PMC6780840__F3 Intracellular peptidoglycan (PGN) is detected by intracellular receptors and activates the NFKB signaling pathway in Drosophila melanogaster and human enterocytes RIPK2 REL TRAF2 PMC7299241__F3 Actions of IGF-1 in the Growth Plate and its Role in Postnatal Bone Elongation BAD IGF1 GSK3B MTOR PMC9589007__F5 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues GGPS1 CYP51A1 MSMO1 EBP SQLE DHCR24 CTRC MVK LBR HMGCS1 CTRL HMGCR ACAT2 PMVK MVD DHCR7 FDPS FDFT1 TM7SF2 PMC7253212__F5 Interaction of FXR signaling and pathways relevant for zileuton-induced hepatotoxicity PPARG CD36 SLC51B FABP1 TCF2 UGT2B10 SLC27A2 PDK2 MYC LIPA SLC22A5 LIPC SLC27A1 MAP2K4 ACADVL ABCG2 ABCC2 ACOX1 CES1 ABCB11 SLC25A17 PLA2G4F UGT2B7 GPX2 NR1C1 CYP2B6 IGF1 IL1RN ACADL PLTP CPT1A HNF1A PMC9589007__F4 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues IDH3B NR1C2 PDK2 CS SLC16A3 SUCLG1 SUCLA2 MDH2 NNT FH ACO2 CTRC PPM2C MPC1 ME1 hEMMPRIN ME3 PDHX SDHA DLAT PDHA1 ME2 OGDH L2HGDH DLD HAGH SDHC PMC5217037__F7 miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NFKB and sustains NFKB activation by decreasing Cylindromatosis expression TNF CYLD TRAF2 PMC7810939__F6 GSEA analysis and gene‐pathway regulatory network in the liver SOCS1 EHHADH SOS1 GPAT2 PIK3R2 AGPAT4 BRAF PRKAG2 DGKB PYGL HADHB HEL-S-80p PDPK1 PHKB ACADVL RPTOR GCDH ACOX1 HK2 ACADS FASN CTSK GLA DGKG KRAS LIPG ALDH3A2 CRK PRKCI FOXO1 ADH6 SOS2 IKBKB CALM1 GRB2 CPT1A PMC9589007__F7 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues FCN2 C6 CD59 CFHR4 CFHR5 CPB2 C1R C4BPB VTN CD46 C1QB C4A CR1 CTRL CFI CLU F2 PROS1 C9 CPN2 CD81 C8G SERPING1 MASP2 FCN3 CFD C1S CFHR1 CFH CPN1 CD55 MASP1 MBL2 CFHR3 C1QA C2 C4BPA C8A CFHR2 C1QC PMC3235520__F1 Proposed model of the type I interferon induction by HIV-1 and HIV-1-infected cells PDC TLR9 IRF3 TLR7 CXCR4 MYD88 PMC9589007__F6 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues TF BDKRB1 SERPIND1 SERPINF2 F2RL2 CPB2 F5 F7 PROCR CTRL PLAT PPBP APOH F2R F2 F10 F3 PROS1 THBD A2M F8 F9 PROC KNG1 VWF SERPINC1 THBS1 SERPING1 PLAUR SERPINA1 PLG HRG F11 CLEC3B TFPI FGA SERPINB2 BDKRB2 PMC4385831__F6 Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFA and ROS production RIPK3 TRADD RELB RIPK1 TNF TRAF2 PMC5331050__F5 NOD-like receptor signaling pathway MAP3K7IP1 TAB3 NOD2 NOD1 IL1B PMC5223597__F8 Proposed model for the role INPP5E plays at cilia MKS1 TCTN1 GPR161 SAG B9D2 B9D1 TMEM231 SMO INPP5E PMC10989355__F4 Molecular signaling pathways affected by electrical stimulation (ES) of peripheral nerves NGF GDNF BDNF PMC10989355__F2 Regulatory signaling pathways activating Schwann cells (SCs) response in peripheral nerve regeneration (PNR) CNTF PIEZO1 SOX10 SRC BDNF PMC10989355__F1 Pivotal signaling cascades in peripheral nerve regeneration (PNR) NGF GDNF FRS2 GSK3B ARHA GRB2 MTOR BDNF PMC5041313__F2 CB1 cannabinoid receptor signaling and regulation of neural stem/progenitor cell proliferation RAP1GAP STAT3 GSK3B SRC PAX6 PMC3712043__F1 Activation of the IRS signaling cascade pathways RHEB TSC2 BAD RICTOR TSC1 IGF1 ULK1 MTOR SHE ULK2 EIF4E PMC5331050__F3 Toll-like receptor signaling pathway CD40 TBK1 TLR9 TLR5 IRF3 TRAF3 TRAF6 MYD88 TLR1 TLR3 TLR4 TLR8 TLR7 IL1B PMC6885362__F4 Whole Transcriptomic Analysis of Apigenin on TNFA Immuno-activated MDA-MB-231 Breast Cancer Cells TH TGFA CDA IL3 APC TNF PMC6548820__F10 The proposed mechanism for the indirect pathway of allorecognition in the T cell areas of the spleen and LNs TH XCR1 DST PMC3000682__F7 Pro-inflammatory pathway induction by cAMP/PKA signaling in BSC-derived lesions COX2 IL1B PMC6885362__F3 Whole Transcriptomic Analysis of Apigenin on TNFA Immuno-activated MDA-MB-231 Breast Cancer Cells CD40 IL19 CD80 TIRAP CTSK CD14 CPO IRF3 IL6 TNF TRAF6 IRAK4 RAC1 MIP LBP CD6 FADD PMC8786804__F5 Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer’s Disease Across Two Brain Regions HEL-S-72p ITGB6 ITGB1 DNAJC7 HSF1 RHO HOXB2 NRXN1 ITGAV SPP1 HOXA5 PMC11734361__F3 Tumor-associated-mycobiome mechanisms involved in triggering oncogenesis and cancer development STAT3 NLRP3 IL33 CARD9 PMC4709785__F1 Metabolic regulation of the pluripotent epigenetic landscape UCP2 OGT PMC11734361__F4 Tumor-associated-mycobiome regulates the physiological and immune responses of cancer through different signaling pathways RASGRF1 HRAS SYK STAT1 BCL10 GYS1 HK2 NOD2 GIP JAK1 RAC1 CARD9 PMC6433964__F3 Repair pathways and signaling in response to DSB induction by IR ATR RAD51 BRCA2 ATM PMC3397239__F2 Anaplasma phagocytophilum: deceptively simple or simply deceptive? SYK CASP8 ROCK1 CASP3 PMC8908320__F8 Novel Copper(II) Indenoisoquinoline Complex Inhibits Topoisomerase I, Induces G2 Phase Arrest, and Autophagy in Three Adenocarcinomas CDC2 ATR ATM MTOR PMC2234385__F10 Model of TLR ligand activation of Kupffer cell–NK cell cross talk in co-culture LTA TLR3 TLR4 MYD88 PMC8524136__F10 Smoothelin-Like Protein 1 Regulates Development and Metabolic Transformation of Skeletal Muscle in Hyperthyroidism SMTNL1 DUSP9 IRS1 PMC4166537__F4 CCR-14-0330R1: Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer WDR12 NKD1 STAG2 FAT4 BRPF1 PTPRU ANK2 EGFR CHD6 SYNE1 RPS11 TRRAP RB1 DDX1 CSMD3 PI3 ATM EP300 LAMA4 AHNAK CUBN PMC8836812__F4 Unraveling the Signaling Secretome of Platelet-Rich Plasma: Towards a Better Understanding of Its Therapeutic Potential in Knee Osteoarthritis IL15 CXCL9 LTA TIMP1 TGFB1 LTBR EGFR CCL15 TNFRSF1A IGFBP1 IGFBP4 IGFBP2 CCL5 GH1 CCL2 CXCL8 IGFBP6 FLT4 IL16 GDF15 BMP4 IL11 CCL1 HMGB1 IL10 CSF2 CXCL13 PROK1 IL13 NGFR BMP7 IL4 KIT IL6 TNF CCL24 PIGF CCL4 IL7 BMP5 TNFRSF11B CP PMC8836812__F3 Unraveling the Signaling Secretome of Platelet-Rich Plasma: Towards a Better Understanding of Its Therapeutic Potential in Knee Osteoarthritis LTA CSF1 LTBR CCL3 CCL2 CXCL8 IFNG NGF FLT4 IL16 CSF1R CCL1 CSF2 IL1A VEGFA TNF HBEGF CCL24 IGF1 CCL4 BMP5 BDNF IL12B CP IL15 CXCL9 EGF TIMP1 HGF TGFA TGFB1 EGFR GH1 INS CSF3 FGF7A NTF4 NTF3 BMP4 IL18 IL2 IL11 IL10 IL12A PROK1 CCL11 IL13 PDGFA NGFR KIT VEGFD BMP7 IL4 IL17A KITLG FGF2 FGF7 PIGF IL7 TNFRSF11B PMC7644826__F2 Canonical WNT signaling APC GSK3B LRP5 LRP6 PMC5127148__F1 Expression of myogenes in longissimus dorsi muscle during prenatal development in commercial and local Piau pigs MYOG HIF1AN SUFU IKBKB CSRP3 CHD8 EID2B MAP2K1 RSPO3 SOX7 LEF1 PMC8470542__F10 Effects of Two Nrf2 Activators, Bardoxolone Methyl and Omaveloxolone, on Retinal Ganglion Cell Survival during Ischemic Optic Neuropathy NQO1 ARG1 PMC7019133__F1 Canonical Wnt/Beta-catenin pathway APC LRP5 LRP6 CTNNB1 PMC7019133__F3 Role of sFRP2 in cardiovascular disease FZD5 PMC5129466__F1 Insulin receptor (IR) and insulin‐like growth factor 1 receptor (IGF1R) signalling pathway IGF1 GSK3B GRB2 PMC5774495__F4 Osteoclast differentiation signaling pathway IFNG SYK IRF9 CTSK BLNK CYLD TRAF2 RAC1 PMC5956974__F11 Function of the hub genes in the cell cycle signaling pathway visualized in the Kyoto Encyclopedia of Genes and Genomes (KEGG) map obtained by the Database for Annotation, Visualization and Integrated Discovery (DAVID) MOS PCNA MAL PMC3797434__F7 IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis TBK1 IRF3 IRF7 TRAF6 IRAK4 MYD88 PMC7784358__F5 KEGG pathway enrichment analysis and pathway map for RA PTER LTB CCL3 ELL CTSL CTSK IL6 PTH CTLA4 CCL2 CCL20 PMC11663348__F1 Stimulation by oral pathogenic bacteria induce dysfunctional PDLFs ECSIT RIPK3 STAT3 PANX1 NLRP3 MLKL TLR4 NOD2 RASA4 PMC5661640__F4 General overview of the process of cell death in SMA BAD PTEN MTOR PMC5661640__F3 Schematic presentation of suggested pathways of PTEN involvement in neuronal survival BAD FAS PTEN MTOR CCND1 PMC3136563__F12 Working model for the role of USP4 in the negative regulation of TNFAlpha-induced TAK1 polyubiquitnation and NFKB activation CSA2 TRADD TAB3 USP11 TNF MAP3K7IP1 USP15 USP4 RELA TRAF5 USP21 REL TRAF2 CYLD PMC11580480__F8 Summary chart EGFR SMAD2 SMAD4 PMC6629629__F3 Clinical update on head and neck cancer: molecular biology and ongoing challenges CDKN2A CDK6 EGFR CDK2 MDM2 MTOR CDK4 PMC10382538__F7 Schematic model of the anti-inflammatory effects of IL4I1 on LPS induced-ALI IFNGR1 AHR PMC6629629__F2 Clinical update on head and neck cancer: molecular biology and ongoing challenges HGF EGFR PTEN MDM2 GRB2 MTOR PMC9682773__F4 Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development TG AHR PMC8798411__F5 Comparison of whole exome sequencing in circulating tumor cells of primitive and metastatic nasopharyngeal carcinoma KRT18 CENPM WNK1 ETS2 CASP12 ZNF880 ZNF492 PCDHGA2 PCDHB13 PCDHGA10 PCDHB16 PABPC1 PABPC3 RANBP2 ZNF479 CNOT1 PCDHA8 ZNF117 PCDHA6 WWTR1 BCR ZNF778 GAB2 SRA1 PMC9682773__F3 Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development TG AHR PMC9682773__F2 Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development AHR CYP1A1 PMC9601130__F1 Novel Approaches in Non-Melanoma Skin Cancers—A Focus on Hedgehog Pathway in Basal Cell Carcinoma (BCC) KIF7 SUFU SMO GLI3 PMC6347823__F7 A schematic model showing the effects of duodenal ghrelin on hepatic glucose fluxes and insulin signals NTS CCK INSR PMC3074487__F8 Migration of FGF7-stimulated epithelial cells and VEGF-A-stimulated HUVECs depends on EGFR transactivation by ADAM17 EGF HBEGF ADAM17 EGFR SRC PMC9233299__F7 Beta-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes SDHB C2 SIRT5 PMC7760327__F1 Cellular copper homeostasis in hepatocytes (A) and fibroblasts (B) CTRL ATOX1 CCS LOX SCO1 CS SCO2 ATP7B COX17 HEL-S-44 ATP7A CP PMC9437524__F1 Neutrophil extracellular traps: New players in cancer research HMGB1 TLR9 CCDC25 MMP9 CTSC PMC6541606__F7 Human mesenchymal stem cells promote tumor growth via MAPK pathway and metastasis by epithelial mesenchymal transition and integrin A5 in hepatocellular carcinoma IL6 TNF PMC6433964__F2 Regulation of PD-L1 expression in response to DNA damage in cancer cells ATR CGAS ATM PMC7002344__F10 Differential phosphorylation of MAPK pathways during response to cell wall damage CDC42 ROM1 CIB2 PAF1 C2 PMC12113985__F7 Novel Camel Milk-Derived Peptide LLPK Improves Glucose-Lipid Metabolism in db/db Mice via PPAR Signaling Pathway ACOX1 EHHADH DPP4 PMC8130364__F1 Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy MTAP BRAF ZEB2 PMC8740229__F2 Targeting TREM2 for Parkinson’s Disease: Where to Go? TREM2 NLRP3 TLR4 PMC3234798__F9 miR-26a pathway in the initiation of ASMC hypertrophy TH EGR1 GSK3B CTDSP2 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260211%WP175%MUS MUSCULUS Acetylcholine synthesis Pcyt1a Pdha1 Pdha2 Chat Pemt Chka Ache STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP55%MUS MUSCULUS Steroid biosynthesis Hsd17b7 Hsd17b3 Hsd17b4 Cyp17a1 Hsd3b6 Hsd3b5 Hsd3b4 Hsd3b3 Hsd3b2 Hsd3b1 Hsd17b1 Hsd17b2 F13b FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5128%MUS MUSCULUS Fibrin complement receptor 3 signaling pathway Ifnb1 Ticam2 Akt1 Irak4 Ccl2 Nfkb1 Ticam1 Lbp Cxcl3 Fgb Fga Pik3ca Syk Nos2 Irak2 Irak1 Fgg Plat Cblb Myd88 Rela Ly96 Irf3 Fcer1g Itgb2 Rel Cd14 Chuk Tlr4 Tirap Tlr3 Ikbkb Cxcl10 Rassf5 Src Tyrobp Traf6 Il12b Ikbkg Plg Tnf Rhoa Il6 Itgam AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260211%WP1262%MUS MUSCULUS Aflatoxin B1 metabolism Akr7a2 Ephx1 Cyp1a2 Gstt1 Gstm1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260211%WP2910%MUS MUSCULUS Mecp2 and associated Rett syndrome Gad1 Apoc2 Gabrr2 Tet1 Tap1 Nrep Myt1 Arhgef26 Mag Mef2c Bcl6 Sst E2f1 Hnrnph1 Hnrnpf Oprk1 Ezh2 Taf1 Cdon Gamt Ncor1 Mecp2 Cnp Gprin1 Sin3a Csrp1 Bdnf Dlx5 Prpf3 Ybx1 Cebpd Fgf2 Smc3 Fgf4 Fgf3 Rbfox1 Rest Fut8 Ctcf Sp1 Sp3 Nf1 Mbp Pou3f2 Grin1 Pou4f1 Creb1 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260211%WP543%MUS MUSCULUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Hmgcs2 Acat1 GPCRS OTHER%WIKIPATHWAYS_20260211%WP41%MUS MUSCULUS GPCRs other Oprk1 Or8g20 Ghsr Gpr165 Or1e1f Gpr162 Prokr1 Adgrg1 Ednra Or8c9 Vmn2r104 Rrh Or1a1b Or1ad8 Or3a1 Or1e35 Or1e34 Vmn1r148 Oprl1 Adrb2 Adrb1 Vmn1r29 Vmn1r25 Or8g19 Or4b1d Or7e178 Or8d1 Sstr5 Smo Or8u8 Or1e23 Or5g26 Vmn2r107 Oprm1 Tacr3 Or4c58 Or51a5 Calcr Casr Vmn1r15 Or1p1 Vmn1r13 Or1x2 Vmn1r14 Vmn1r11 Or2a7 Or6a2 Tas1r1 Vmn1r10 Or2z2 Ccr10 Or9s13 Or10p22 Vipr1 Gpr88 Gpr84 Gpr83 Drd1 Celsr3 Drd2 Or6z7 Celsr1 Or7a37 Drd5 Celsr2 Fzd1 Xcr1 Fzd2 Fzd5 Fzd7 Or6b9 Fzd9 Or13p10 Or2b6 Or1a1 Or7e165 Adora1 Adora3 Ltb4r2 Or2n1e Or2t1 Tmigd3 Grm1 Gabbr1 Or51a10 Or1j1 Ccr7 Or13a18 Or13a17 Gpr132 Or7a42 Or7a41 Or7a40 Or2ag2b Mtnr1b Vmn2r32 Vmn1r65 Vmn1r62 Vmn1r63 Gpr39 Htr1d Or2y1b Gpr34 Htr1a V1ra8 Or13a28 Or13a27 Gpr143 Adgre5 Vmn1r58 Or2v1 Vmn1r56 Vmn1r53 Vmn1r54 Vmn1r51 Vmn1r52 Gpr146 Vmn1r50 Or3a1c Mc4r Or1e17 Or1d2 Or1e16 S1pr1 Pth2r S1pr2 S1pr5 Trhr2 Or51a39 Adgrf4 Vmn1r48 Vmn1r49 Vmn1r46 Or2w1 Vmn1r47 Gpr37l1 Irx6 Vmn1r44 Cysltr1 Vmn1r45 Vmn1r42 Vmn1r43 Ackr1 Vmn1r40 Cnr1 Vmn1r41 Or1f19 Or1j21 Mrgprh Or2a57 Vmn1r171 Vmn1r172 Or1m1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260211%WP4820%MUS MUSCULUS GDNF RET signaling axis Gdnf Sox11 Fat4 Gata3 Gfra1 Sall1 Robo2 Ret Grem1 Eya1 Sox17 Ift27 Agtr2 Slit2 Ctnnb1 Spry1 Pax2 Ift25 Gli3 Foxc2 Bmp4 Lhx1 Foxc1 GPCRS ORPHAN%WIKIPATHWAYS_20260211%WP1398%MUS MUSCULUS GPCRs orphan Gpr137b Adgrf5 Gpr137c Slc52a2 Gpr161 Adgrf2 Gpr180 Gpr107 Gpr137 Gpr4 Gpr179 Gpr155 Tpra1 Gpr108 Gpr89 Gpr31 Wls Gpr165 PURINE METABOLISM%WIKIPATHWAYS_20260211%WP2185%MUS MUSCULUS Purine metabolism Gda Pde7b Pde7a Entpd1 Nt5c Entpd2 Nt5c1a Pnp Nt5e Nt5c1b Entpd5 Pde6g Entpd6 Pde6h Entpd3 Entpd8 Nt5m Allc Polr1b Polr1c Ak1 Polr1a Ak2 Ak5 Polr1d Ak4 Polr1e Hprt1 Pde8a Ak7 Pde8b Ak6 Polr1h Ak8 Cant1 Ampd3 Ampd2 Ampd1 Adcy10 Npr1 Pola2 Pnp2 Pola1 Npr2 Adprm Pde9a Gucy1b1 Gucy1b2 Nt5c3a Pnpt1 Itpa Dguok Adss2 Adss1 Gucy1a2 Pde1b Ppat Pde1c Pde1a Paics Ada Pde10a Rrm2b Urad Adk Pde3a Urah Nudt16l2 Guk1 Pde2a Adcy3 Adcy4 Pgm2 Adcy1 Adcy2 Adcy7 Gart Adcy8 Pgm1 Adcy5 Adcy6 Pold2 Pold1 Adcy9 Nudt16 Pold4 Pold3 Pde4a Nme3 Gmps Pde4b Prps1l3 Nme2 Gmpr Nme5 Prps1l1 Nme4 Fhit Dck Nme1 Prim2 Prps1 Gucy2e Gucy2d Prps2 Gmpr2 Gucy2c Atic Pkm Nme7 Nme6 Pde3b Prim1 Gucy2f Pole3 Pole2 Adsl Impdh2 Pklr Polr2c Polr2d Polr2a Impdh1 Polr2b Taf9 Pole4 Polr2g Enpp1 Polr2h Enpp3 Polr2e Polr2f Pde5a Polr2l Polr2i Aprt Polr2j Polr3gl Pde4c Pde4d Nudt2 Hddc3 Xdh Nudt5 Polr3a Rrm1 Nudt9 Pde11a Rrm2 Polr3d Polr3e Polr3b Prune1 Polr3c Pde6c Polr3h Pde6d Pde6a Polr3f Pde6b Polr3g Pfas Polr3k Papss2 Papss1 Nt5c2 Pole Uox MRNA PROCESSING%WIKIPATHWAYS_20260211%WP310%MUS MUSCULUS mRNA processing Polr2a Polr2g Afg3l2 Afg3l1 Phf5a Igf2bp3 Rbm15b Igf2bp1 Eif2ak2 Rpl37 Rpl38 Rpl8 Rpl39 Rpl9 Rpl7 Znf830 Rpl32 Abcb4 U2surp Lsm11 Vmn1r26 Trmt2a Clp1 Rpl26 Snrpb2 Trmt1l Mbnl1 Rpl22 Snu13 Fdx2 Raly Cfb Dcaf1 Rad21 Snrpa1 Bard1 Mettl3 Ptbp1 Cpeb1 Cpeb3 Cpeb4 Rpl39l Eif4a3 Rnpc3 Eif4a2 Mcts2 Wdr55 Scaf8 Pabpc1 Pabpc2 Nelfe Tmed10 Zfp638 Csad Srp68 Pabpc4 Pabpc5 Pabpc6 Stau1 Rbm12b1 Rbm12b2 Slbp Zfp740 Srp9 Dazl Tert Rbm8a Tut1 Nip7 Gatc Rpl19 Sf3a1 Sf3a2 Sf3a3 Rpl11 Rpl12 Dazap1 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Dnajc17 Sf3b5 Sf3b6 Akap17b Srp54 Adat1 Atxn1 Fmr1 Rnpepl1 Msi1 Msi2 Alyref2 Rbm31y Hnrnpa2b1 Supt5h Rps9 Rps7 Rnmt Snrnp70 Rps6 Ilf3 Ncl Hnrnpdl Spop Zcrb1 Virma Htatsf1 Tmem163 Oasl2 Snrnp40 Prpf18 Eftud2 Snrpf Snrpe Snrpg Snrpb Snrpa Snrpc Snrpn Alyref Ppp1r14b Ggcx G3bp1 Smn1 Elmod3 Mrpl23 Tia1 Col4a3 Fus Cnot4 Lsm2 Lsm4 Secisbp2 Qki Lsm1 Cdk9 Son Lsm7 Lsm8 Rbpms Safb2 Eral1 Synj2 Aco1 Sbno1 Hnrnpab Ilkap Mrpl11 Rnpep Clasrp Srsf1 Ptbp3 Ptbp2 Ddx19b Srsf9 Srsf7 Ddx19a Srsf6 Srsf5 Adam5 Srsf4 Dis3 Srsf3 Srsf2 Ankar Eif4h Tsn Eif4e Snrnp35 Hnrnpa3 Pcolce Sart3 Puf60 Wbp4 U2af1 Ppil4 Eif3g Eif3b Mrm3 Hnrnpa1 Hnrnpa0 Zfp385a U2af2 Bicc1 Cstf2t Ciz1 Ssb Celf6 Celf5 Celf4 Celf3 Celf2 Eif2d Celf1 Pabpn1 Pskh1 Ro60 Sfswap Mak16 Park7 Ppm1g Dicer1 Slc25a4 Rngtt Smc1a Enox1 Enox2 Rps14 Rnps1 Ltv1 Rps11 Rps13 Myef2 Rbfox2 Prpf40a Prpf40b Cirbp Uhmk1 Cdc40 Ddx39a Hnrnpll Esrp2 Pcbp2 Imp3 Pcbp1 Ddx39b Pcbp4 Esrp1 Pcbp3 Imp4 Xrn2 Alkbh8 Hnrnpr Dhx8 Dhx9 Hnrnpu Rbms1 Rbm11 Rbms3 Rbm10 Rbms2 Rbm12 Fxr1 Oas1g Fxr2 Oas1b Oas1a Dhx38 Dnd1 Elavl4 Elavl2 Adarb2 Elavl3 Elavl1 Tial1 Rps27 Rps28 Aimp1 Rps29 Rps20 Pum2 Pum3 Sugp1 Rps23 Sugp2 Pum1 Rps24 Srpk1 Zrsr2 Hnrnpc Hnrnpd Hnrnpk Hnrnpl Srpk2 Hnrnpm Adad1 Cstf1 Nudt21 Prmt1 Auh Sltm Prmt2 Dhx16 Cstf2 Cstf3 Dhx15 Rsrc2 Rnasel Akap1 Slc6a8 Csde1 Rbpms2 Srsf11 Srsf12 Srsf10 Srrm1 Boll Prpf4b Slu7 Tlr5 Raver1 Nol8 Rae1 Npm1 Bclaf1 Ppargc1a Ppargc1b Ergic2 Tardbp Znf346 Brca1 Rnaset2b Hnrnph2 Prpf4 Prpf6 Rbmxl2 Rbmxl1 Pspc1 Zmat4 Zmat2 Rdm1 Fbl Ppie Tarbp2 Syncrip Zbp1 Rbmx2 Matr3 Mrps28 Rbm4b Prpf8 D1Pas1 Brwd1 Papolg Ppp1r8 Nono Papolb Papola Grsf1 Nop9 Clk1 Clk2 Clk3 Clk4 Ralyl Cpsf4 Cpsf7 Srp14 Cpsf1 Cpsf2 Cpsf3 Ddx1 Tdrd7 Ddx4 Ddx5 Srp19 Ddx6 Eif4e2 Slirp Rbm33 Dnajc8 Dis3l2 Rbm34 Taf15 Rbm26 Rbm3 Ddx3x Rbm4 Nufip1 Rbm25 Rbm28 Sfpq Lingo1 Ddx56 Rbm7 Rbm5 Rbm6 Ewsr1 Txnl4a Adar Naa38 Rbm22 Rbm14 Rbm17 Rbm19 Oas2 Rbm18 Ankrd33b Oas3 Ddx41 Spen Nifk Eif4g2 Poldip3 Eif4g3 Rpp14 Trim21 Nxf1 Rbm47 Ncbp2 Cyp4f3 Rbmy Cd2bp2 Rbmx Nxf7 Rps4x Snrpd2 Tnrc6c Snrpd1 Tra2b Acin1 Rbm42 Rbm41 Rbm43 Snrpd3 Rbm45 Rbm39 Rbm38 Ttc14 Znf622 Eif4e3 Ddx25 Naa12 Rnaseh2a Ddx24 Ddx21 Ddx20 Ttc39a Traf6 Prpf3 Ybx1 Rbfox1 Hnrnph1 Hnrnpf EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260211%WP318%MUS MUSCULUS Eicosanoid synthesis Pla2g6 Ptgs2 Ltc4s Tbxas1 Alox8 Alox5ap Pla2g2a Alox12 Alox5 Dpep1 Lta4h Alox15 Ptges Ptgds Ptgis Ptges2 Pnpla8 Ptgs1 Ggt1 ROBO4 AND VEGF SIGNALING PATHWAYS CROSSTALK%WIKIPATHWAYS_20260211%WP3864%MUS MUSCULUS Robo4 and VEGF signaling pathways crosstalk Vegfa Kdr Rac1 Src Slit2 Robo4 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260211%WP509%MUS MUSCULUS Nuclear Receptors Nr2c2 Nr3c1 Nr2e1 Hnf4a Nr1i3 Nr1i2 Ar Esrra Esrrb Rara Rarb Nr2f6 Rarg Thrb Nr1d2 Thra Nr0b1 Vdr Nr2f2 Nr2f1 Nr1h3 Rorc Ppard Nr1h2 Rora Ppara Esr1 Pparg Esr2 Rxrb Rxra Ror1 Pgr Rxrg Nr5a2 Nr5a1 Nr4a2 Nr4a1 CELL CYCLE%WIKIPATHWAYS_20260211%WP190%MUS MUSCULUS Cell cycle E2f6 Atr Smc1b Ccna1 Ccna2 Mcm7 Ccne1 Ccne2 Dbf4 Ywhag Hdac3 Hdac2 Hdac5 Hdac4 Cdh1 Hdac1 Cdkn2a Hdac7 Tfdp1 Skp2 Hdac6 Pkmyt1 Cdc20 Ccnb2 Ccnb3 Mad2l2 Ccnb1 Pcna Ccnh Espl1 Mad2l1 Gsk3b Rbl1 Mcm3 Bub1b E2f1 Mcm4 Mcm5 Mcm6 Cdc25c Cdc25b Mcm2 Cdc25a Chek1 Chek2 Ep300 Gadd45a Orc5 Orc4 Tgfb1 Orc6 Prkdc Orc1 Orc3 Orc2 Abl1 Bub3 Cdc45 Mpeg1 Bub1 Cdc14b Cdc14a Rb1 Ccnd2 Ccnd3 Plk1 Trp53 Pttg1 Cdc7 Cdc6 Mad1l1 Smad3 Wee1 Cdk6 Smad4 Cdk4 Cdk2 Cdk1 Mdm2 E2f2 Tbc1d8 E2f3 Atm E2f4 Cdkn1a E2f5 Cdkn1b ESTROGEN SIGNALING%WIKIPATHWAYS_20260211%WP1244%MUS MUSCULUS Estrogen signaling Akt1 Mapk9 Mapk1 Ilk Nfkb1 Braf Elk1 Mnat1 Taf13 Taf12 Gtf2f2 Pik3ca Hdac8 Tbp Prkaca Fos Polr2c Gtf2a2 Gtf2b Polr2a Gtf2e1 Sos1 Polr2b Gtf2e2 Taf9 Shc2 Polr2g Polr2k Gnas Polr2h Gtf2h2 Gtf2h1 Polr2e Gtf2h4 Polr2f Gtf2h3 Chuk Gngt1 Jun Polr2i Mapk14 Ercc2 Polr2j Ccnd1 Gper1 Esr1 Ercc3 Crebbp Cdk7 Ncor1 Map2k1 Gnb1 Bcl2 Taf7 Sin3a Grb2 Taf6 Taf5 Hras Hdac3 Hdac2 Hdac5 Hdac4 Ak6 Sp1 Hdac1 Hdac7 Hdac6 Creb1 Ccnh Ep300 Ikbkb Src Ikbkg Brca1 ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP1261%MUS MUSCULUS ErbB signaling pathway Cblc Araf Nrg2 Nrg1 Mapk1 Areg Ptk2 Egfr Elk1 Btc Stat5a Gsk3b Nrg4 Nrg3 Pik3r5 Prkca Crk Sos1 Shc2 Jun Abl1 Map2k1 Grb2 Hras Mapk8 Erbb2 Erbb4 Erbb3 Eif4ebp1 Map2k7 Ereg Hbegf Mtor Src Camk2a Myc Akt3 Pak4 Nck1 Bad Egf Plcg1 Cdkn1a Gab1 Tgfa Cdkn1b SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260211%WP2140%MUS MUSCULUS Serotonin and anxiety related events Ppp3ca Plek Fos Plcd4 Nlgn1 Arc Prkcb Crh Htr2a Htr2c Crhr1 Grin2d Htr1a ELECTRON TRANSPORT CHAIN%WIKIPATHWAYS_20260211%WP295%MUS MUSCULUS Electron transport chain Sdhd Sdhc Sdhb Sdha Cox7a2l Cox6a1 Cox6a2 Uqcrfs1 Sco1 Uqcrq Coxfa4 ATP6 Atp5f1e Atp5f1d Atp5f1c mt-Atp8 Atp5mf Atp5me Cox8a Cox6b1 Ndufv2 Dmac2l Atp5mg Ndufv1 Surf1 Atp5f1b Cox15 Ndufv3 Atp5f1a Uqcrb Cox17 mt-Co2 mt-Co3 mt-Cytb Uqcrh mt-Nd4 mt-Nd5 mt-Nd6 Ndufab1 Ndufc1 mt-Co1 Ndufc2 mt-Nd1 mt-Nd2 mt-Nd3 Ndufa12 Ndufa10 Cox7b Ndufs1 Slc25a27 Ndufs3 Ndufs2 Ndufs5 Cox4i1 Slc25a4 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Atp5mc3 Atp5mc2 Cox5b-ps Slc25a14 Cox6c Ndufa1 Ucp1 Ndufa3 Ndufa2 Ndufa5 Atp5pb Ndufa7 Atp5pd Ndufa6 Ndufa9 Ndufa8 Atp5pf Ndufb10 Cox7a1 Cox7a2 Atp5po Ucp2 Ucp3 Cox5a Ndufb2 Ndufb4 Uqcrc2 Ndufb3 Ndufb6 Uqcrc1 Ndufb5 mt-Nd4l Ndufb7 Ndufb9 Atp5if1 Uqcr10 Uqcr11 Slc25a5 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2872%MUS MUSCULUS White fat cell differentiation Egr2 Mecom Ddit3 Ebf1 Gata3 Ctnna1 Klf4 Klf2 Stat5b Nr3c1 Stat5a Klf5 Zfp423 Irf4 Klf15 Gata2 Srebf1 Rara Irf3 Nr2f2 Nr1h3 Rora Pparg Cebpd Ins1 Cebpb Cebpa Tcf7l1 Wnt10b Foxo1 Creb1 Tle3 G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP298%MUS MUSCULUS G13 signaling pathway Rac1 Pik3ca Gna13 Arhgef1 Sra1 Was Arhgdib Map3k4 Arhgdig Rps6kb1 Iqgap1 Pak3 Pik3cb Pik3cd Iqgap2 Cdc42 Ppp1cb Rtkn Diaph1 Tnk2 Cfl1 Cfl2 Wasl Rhpn2 Sh3rf1 Cit Myl1 Limk1 Rock2 Mybph Pkn1 Rock1 Pfn1 Pik3r2 Mapk10 Pip4k2a Rhoa TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260211%WP1245%MUS MUSCULUS Transcriptional activation by Nfe2l2 in response to phytochemicals Pik3ca Prkca Mapk8 Nqo1 Aimp2 Gsta2 Hmox1 Nfe2l2 Ephb2 Gclc Maf Keap1 Gclm Cebpb MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP401%MUS MUSCULUS Mitochondrial long chain fatty acid beta oxidation Cpt2 Acads Acadvl Cpt1a Acsl1 Scp2 Acsl3 Acsl4 Slc25a20 Hadh Hadha Pecr Acadl Eci1 Ehhadh Acadm INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP458%MUS MUSCULUS Inflammatory response pathway Zap70 Fn1 Il2ra Il2rb Il2 Tnfrsf1b Il4 Vtn Tnfrsf1a Il5 Ifng Lamb2 Cd40lg Cd28 Lamb1 Cd86 Col1a2 Col3a1 Cd40 Col1a1 Cd80 Lama5 Il2rg Lck Il4ra Il5ra Lamc1 Lamc2 Thbs1 Thbs3 TGF BETA SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP113%MUS MUSCULUS TGF beta signaling pathway Mapk9 Nfkb1 Fos Ifng Jun Crebbp Thbs1 Fkbp1a Mapk3 Tgif1 Ltbp1 Jak1 Hras Fst Tfe3 Nog Itgb6 Zeb2 Foxh1 Serpine1 Skil Eng Lef1 Spp1 Runx3 Wnt1 Runx2 Tgfbr3 Egf Lif Smad1 Smad2 Zfyve9 Stat3 Smad9 Bambi Inhba Stat1 Tgfbr1 Smad5 Tgfbr2 Smad6 Zfp423 Smad7 Ep300 Tgfb1 Smad3 Smad4 Ctnnb1 Tnf Bmp4 FOLIC ACID NETWORK%WIKIPATHWAYS_20260211%WP1273%MUS MUSCULUS Folic acid network Xdh Fads2 Gpx2 Gpx1 Gpx4 Gpx3 Gpx6 Gsr Msrb1 Mtr Selenow Kmo Alox5 Txnrd1 Txnrd2 Cbs Cat Ptges Pnpo Ptgds Mthfr Ptgis Selenok ECTODYSPLASIN A SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260211%WP3652%MUS MUSCULUS Ectodysplasin A signaling in hair follicle development Edaradd Relb Edar Dkk4 Shh Ptch1 Nfkb1 Nfkb2 Ltb Rela Eda Sostdc1 Gli1 Dkk1 MIR 1 IN CARDIAC DEVELOPMENT%WIKIPATHWAYS_20260211%WP608%MUS MUSCULUS miR 1 in cardiac development Irx5 Hand2 Kcnd2 ELONGATION OF VERY LONG CHAIN FATTY ACIDS%WIKIPATHWAYS_20260211%WP4491%MUS MUSCULUS Elongation of very long chain fatty acids Fads2 Scd4 Fads1 Elovl2 Elovl3 Elovl4 Elovl5 Fasn Elovl1 Scd3 Scd2 Scd1 Elovl6 Elovl7 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP450%MUS MUSCULUS IL 2 signaling pathway Hsp90aa1 Crkl Akt1 Jak3 Mapk9 Foxo3 Mapk1 Jak2 Nfkb1 Stam2 Gab2 Rack1 Vav1 Nr3c1 Ifna1 Icam1 Pik3r1 Pik3ca Il2ra Syk Raf1 Il2rb Cd53 Shc1 Il2 Ptpn6 Itm2b Stam Cbl Sos1 Ptpn11 Rela Pik3cg Kras Fyn Prkcz Lyn Mapkapk2 Ptk2b Nmi Chuk Map2k2 Mknk1 Mapk14 Cish Il2rg Lck Map2k1 Bcl2 Mapk3 Grb2 Jak1 Mapk8 Ybx1 Mtor Creb1 Stat3 Stat1 Stat5b Stat5a Crk Rps6kb1 Pik3cb Pik3cd Eif4e Pik3r2 Eif3b Socs1 Socs3 Irs1 Irs2 Ets1 Shb Ets2 Plcb1 Tert SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260211%WP4344%MUS MUSCULUS Sphingolipid metabolism overview Sptlc1 Sgpl1 Cerk Sptlc2 Smpd1 Degs2 Degs1 Cers6 Plpp3 Cers4 Cers3 Plpp1 Cers2 Asah1 Sphk2 Sgms1 Sphk1 Sgms2 Kdsr Sgpp2 Ugcg Ugt8 Sgpp1 Lass1 METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260211%WP1251%MUS MUSCULUS Metapathway biotransformation Gpx5 Hs3st3a1 Chst1 Sult2a1 Chst3 Chst2 Chst5 Chst4 Chst7 Cyp24a1 Chst9 Naa30 Chst8 Cyp20a1 Gstp1 Cyp7a1 Gstz1 Hs3st4 Hs3st1 Hs3st2 Gsta3 Gsta4 Gsta1 Hs3st5 Cyp2s1 Hs3st6 Cyp4f39 Baat Naa20 Akr1d1 Kcnab1 Gstm1 Cyp51a1 Akr7a2 Kcnab2 Ephx1 Ugt1a10 Cyp1a2 Kcnab3 Gstt1 Sult1e1 Gal3st1 Cyp4v3 Cyp2r1 Gss Fmo1 Fmo3 Fmo2 Fmo5 Hs6st3 Hs6st2 Fmo4 Hs6st1 Cyp26c1 Akr1b10 Cyp21a1 Gal3st4 Gal3st3 Gpx2 Gpx1 Gpx4 Gpx3 Gsr Cyp4f3 Chst10 Chst11 Chst12 Cyp2u1 Chst13 Chst14 Cyp26b1 Gstk1 Comt Cyp1b1 Naa80 Ndst1 Ndst2 Cyp4x1 Sult1c2 Ndst3 Ndst4 Sult4a1 Cyp26a1 Cyp11b1 Cyp1a1 Cyp11b2 Gstt2 Cyp2w1 Sult1b1 Ugt1a6 Ugt1a9 Hs3st3b1 Gstm7 Ugt1a2 Gstm5 Cyp19a1 Ugt1a5 Gstm4 Cyp27b1 Cyp2f2 Gstcd Cyp11a1 Cyp4b1 Glyat Cyp8b1 Hs2st1 Tpmt Sult1a1 Hnmt Naa50 Cyp27a1 Cyp46a1 Ugt1a1 Nat8 Nat2 Cyp17a1 Cyp2e1 Ephx2 Akr1a1 Nat9 Sult2b1 Sult6b1 Ugt2a2 Nat8l Inmt Gsta2 Cyp39a1 Ugt2a3 Naa40 Gsto1 Mgst3 Gsto2 Nat10 Mgst2 Akr1b1 Mgst1 Nat14 Cyp7b1 Nnmt OXYLIPINS PATHWAYS%WIKIPATHWAYS_20260211%WP5140%MUS MUSCULUS Oxylipins pathways Ptgs2 Ltc4s Fads2 Ephx2 Gpx1 Fads1 Tbxas1 Alox8 Alox12 Cbr1 Alox5 Prxl2b Dpep1 Hpgds Lta4h Hpgd Alox15 Ptges Ptgds Ptgis Ggt1 TRANSLATION FACTORS%WIKIPATHWAYS_20260211%WP307%MUS MUSCULUS Translation factors Eif4ebp1 Eef1a2 Eef1d Eef1a1 Eef1g Eif2ak1 Eif2ak3 Eef1b Eif1a Eif5a Paip1 Eif4b Eif3j1 Etf1 Eif2ak2 Eif3i Eif4ebp2 Eif3f Eif3e Eif4g1 Eif3h Eif4g2 Eif4ebp3 Eif3a Eif4g3 Eif3d Eif3c Eif2b3 Eif2b2 Eif2b5 Eif2b4 Eif2s2 Eif2s1 Eef2k Eif2b1 Eef2 Eif1 Eif5 Eif6 Eif4a1 Eif2s3x Eif2s3y Eif4h Eif4a2 Eif4e Pabpc1 Pabpc2 Eif3g Eif3b NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2074%MUS MUSCULUS Neural crest differentiation Nfkb1 Hdac8 Dlx5 Fgf2 Wnt1 Mbp Smad1 Neurog1 Mitf Cdh7 Cdh6 Fgf8 Cdh2 Mpz Myb Nfkb2 Sox9 Sox5 Twist1 Mia Msx2 Msx3 Hoxb1 Isl1 Foxd3 Prtg Olig3 Axin1 Axin2 Olig2 Olig1 Phox2b Gfap Tfap2a Tfap2b Hdac11 Hdac10 Ets1 Wnt3a Id1 Dvl1 Dvl2 Dvl3 Sox10 Fzd3 Snai2 Snai1 Rbpj Fgfr3 Bmp7 Fgfr1 Fgfr2 Lhx2 Gjb1 Tlx2 Tcf4 Lhx5 Fgf15 Rhob Hey2 Ctbp2 Zic1 Hdac9 Ascl1 Dmbx1 Hand1 Pax3 Bmyc Notch4 Itgb1 Dct Notch1 Pax7 Notch2 Notch3 Wnt8a Col11a2 Hoxa1 Dll1 Dll3 Dll4 Gbx2 Hes1 Hes5 Col2a1 Pmp22 Zic5 Tbx6 Hdac3 Hdac2 Hdac5 Hdac4 Cdh1 Hdac1 Hdac7 Tcf7l1 Hdac6 Gsk3b Ctnnb1 Bmp4 Lhx1 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260211%WP2075%MUS MUSCULUS Alzheimer 39 s disease Mapk1 Tnfrsf1a Mapk3 Plcb4 App Plcb3 Cacna1f Cacna1c Atp2a1 Cacna1d Atp2a3 Atp2a2 Apbb1 Ide Adam17 Plcb2 Ryr3 Bad Hsd17b10 Cacna1s Grin1 Eif2ak3 Adam10 Nos1 Mapt Bace1 Mme Chp1 Chp2 Cdk5r1 Ern1 Psenen Apaf1 Gsk3b Psen1 Fadd Psen2 Atf6 Snca Grin2a Ppp3ca Ncstn Aph1a Ppp3r2 Lrp1 Ppp3r1 Calm4 Lpl Calm2 Gnaq Calml3 Grin2d Nae1 Bid Casp12 Casp8 Casp7 Ppp3cc Ppp3cb Casp9 Casp3 Capn1 Capn2 Cdk5 Il1b Fas Apoe Itpr3 Grin2c Itpr2 Trp53 Grin2b Itpr1 Tnf Plcb1 ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP252%MUS MUSCULUS Androgen receptor signaling pathway Ube3a Rad54l2 Akt1 Pxn Bag1 Mapk1 Hmgb2 Psmc3ip Cav1 Igf1 Mmp1a Fhl2 Ywhah Gtf2f2 Ghr Pou2f1 Rac3 Rnf14 Calr Pou2f2 Nr0b2 Plagl1 Spdef Rela Etv5 Svil Il6st Ncor2 Tmf1 Gtf2h1 Hspa1a Rnf4 Appl1 Ncoa2 Jun Ncoa1 Ncoa4 Ncoa3 Ccnd1 Nsd1 Pnrc1 Pak6 Crebbp Sry Cdk7 Runx1 Casp1 Map2k1 Pten Stub1 Tgfb1i1 Sin3a Rchy1 Tgif1 Ran Hipk3 Sp1 Runx2 Stat3 Egfr Cdk9 Nr2c2 Nr3c1 Raf1 Ar Slc25a4 Cox5b-ps Nr0b1 Esr1 Esr2 Nr5a1 Ccne1 Hdac1 Ccnh Cdc25b Ep300 Prmt1 Casp8 Casp7 Casp3 Rb1 Trp53 Atf2 Nrip1 Pias3 Uxt Smad3 Pias4 Ctdp1 Kat5 Smad4 Ube2i Kat7 Gtf2f1 Cdk1 Src Ctnnb1 Pias1 Mdm2 Pias2 Tle5 Patz1 Brca1 Flna Cdc37 Pa2g4 Ranbp9 Il6 Senp1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260211%WP1498%MUS MUSCULUS Dopaminergic neurogenesis Stat3 Ascl1 Tgfb1 Gli1 Fgf8 Shh Gbx2 Nr4a2 Ddc Neurog2 Aldh1a1 En2 Ret En1 Nkx2-2 Nkx6-1 Gli2 Sox2 Th Slc18a2 Otx2 Msx1 Wnt1 Slc6a3 Lmx1a Lmx1b Neurod1 Pitx3 Foxa2 Cdkn1c FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260211%WP3675%MUS MUSCULUS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling Jkamp Pld1 Igfbp3 Akt1 Igfbp2 Igfbp5 Ilk Igfbp4 Nfkb1 Igfbp1 Pdk1 Igf1 Mstn Igfbp7 Igfbp6 Tnfsf9 Trim63 Prkab1 Acvr2b Igf1r Tnfrsf1a Rps6kb1 Itgb1 Pten Smad3 Mtor Ppargc1a Irs1 Tnf Foxo1 Smad2 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP336%MUS MUSCULUS Fatty acid biosynthesis Acsl1 Acsl3 Acsl4 Hadh Mecr Pcx Fasn Ech1 Echdc3 Echdc1 Echdc2 Scd1 Decr1 Acly Echs1 Acss2 Acaa2 Pecr Acsl5 Acsl6 Acacb Acaca WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP539%MUS MUSCULUS Wnt signaling pathway Akt1 Mapk9 Mapk1 Sall1 Fhl2 Tbp Jun Ccnd1 Mapk3 Mapk8 Lef1 Camk2a Wnt1 Runx2 Prkca Prkcb Map3k7 Dkk1 Sox1 Wnt5a Tax1bp3 Cxxc4 Skp1 Ppp2ca Myb Daam1 Sox9 Magi3 Ror2 Crybb2 Btrc Senp2 Vangl2 Ruvbl1 Nlk Dab2 Wnt2 Wnt4 Axin1 Wnt3 Axin2 Jup Fzd4 Fzd6 Fzd8 Bcl9 Tfap2a Dlg1 Dlg2 Dlg4 Cul1 Wnt3a Pin1 Tcf3 Dvl1 Csnk2a2 Dvl2 Csnk2a1 Dvl3 Mark2 Ctbp1 Sfrp2 Sfrp1 Csnk2b Rac1 Csnk1d Csnk1e Sumo1 Lrp6 Csnk1a1 Lrp5 Camk2g Raf1 Nkd1 Tcf4 Camk2d Camk2b Arrb2 Arrb1 Wnt7a Ctbp2 Brd7 Map1b Ctnnbip1 Ankrd6 Apc Mapk8ip1 Fzd1 Frat2 Frat1 Fzd2 Hipk2 Fzd5 Fzd7 Fzd9 Nr5a1 Cdh1 Gsk3b Cdc25c Lrp1 Ep300 Smad3 Pias4 Smad4 Cdk1 Ctnnb1 Pax2 Rhoa G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260211%WP413%MUS MUSCULUS G1 to S cell cycle control E2f6 Mnat1 Prim1 Pole2 Tfdp2 Cdkn2b Cdkn2c Cdkn2d Ccng2 Ccnd1 Rpa1 Rpa2 Rpa3 Cdk7 Ccna1 Mcm7 Ccne1 Ccne2 Myc Cdkn2a Tfdp1 Pole Pkmyt1 Cdkn1c Pola2 Pcna Ccnh Rbl1 Mcm3 E2f1 Mcm4 Mcm5 Mcm6 Mcm2 Cdc25a Gadd45a Orc5 Orc4 Orc6 Orc1 Orc3 Orc2 Cdc45 Rb1 Ccnd2 Ccnd3 Trp53 Wee1 Cdk6 Cdk4 Cdk2 Cdk1 Mdm2 E2f2 E2f3 Atm Prim2 E2f4 Cdkn1a E2f5 Cdkn1b GLUTATHIONE AND ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP730%MUS MUSCULUS Glutathione and one carbon metabolism Gpx2 Gpx1 Gpx4 Gpx3 Gsr Mtr Cbs Mthfr Ahcyl2 Bhmt Shmt2 Dnmt3a Shmt1 Gss G6pdx Mat2b Ggt5 Ahcy Mtrr Idh1 Amt Chdh Anpep Dnmt3b Dnmt1 Cth Mat1a Oplah Gclc Gclm Ggt1 SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260211%WP108%MUS MUSCULUS Selenium metabolism selenoproteins Sars1 Sepsecs Fabp1 Selenom Selenon Nfkb1 Selenoo Selenop Dio1 Selenos Secisbp2 Selenot Dio2 Gpx2 Dio3 Pou2f1 Gpx1 Selenov Gpx4 Sephs2 Gpx3 Sephs1 Gpx6 Fos Trnau1ap Pstk Msrb1 Selenow Rela Txnrd1 Txnrd2 Selenok Jun Cth Nfe2l2 Selenbp2 Selenbp1 Txnrd3 Sp1 Rpl30 Sp3 Eefsec Crem Scly Sars2 Selenoh Selenoi FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP1269%MUS MUSCULUS Fatty acid beta oxidation Cpt2 Acads Acadvl Cpt1a Acsl1 Acsl3 Acsl4 Slc25a20 Hadh Hadhb Gk Pnpla2 Gcdh Lpl Crat Decr1 Tpi1 Acat1 Gk2 Echs1 Lipc Acss2 Gpd2 Lipe Lipf Acsl5 Acsl6 Cpt1b Chkb Dld Hadha Acadl Eci1 Acadm HYPOXIA DEPENDENT DIFFERENTIATION OF MYOBLASTS%WIKIPATHWAYS_20260211%WP5025%MUS MUSCULUS Hypoxia dependent differentiation of myoblasts Hif1an Bhlhe40 Egln1 Myh1 Vegfa Hif1a Myf6 Myf5 Notch1 Cdkn1a Mapk14 Myog Cdkn1b GPCRS PEPTIDE%WIKIPATHWAYS_20260211%WP234%MUS MUSCULUS GPCRs peptide Ccr2 Galr2 Galr3 Cckbr Galr1 Npy4r Cx3cr1 Lhcgr Avpr2 Sstr4 Ccr10 Sstr3 Sstr2 Mc1r Sstr1 Avpr1b Mc5r Tacr1 Avpr1a Tacr2 C5ar1 Fpr1 Nmbr Bdkrb2 Bdkrb1 Tshr Agtr1a Agtr1b Ccr1 Oxtr Npy2r Npy6r Grpr Mc3r Ccr1l1 Ccr7 Mc4r Oprk1 Ghsr Ednra Cckar Ednrb Cxcr2 Oprl1 Npy1r Cxcr3 Gnrhr Npy5r Ntsr2 Ntsr1 Trhr Brs3 Fpr-s1 Sstr5 Mc2r Oprd1 Fshr Agtr2 C3ar1 Ccr9 Cxcr4 Oprm1 Cxcr5 Tacr3 Ccr8 Cxcr6 Ccr6 Ccr5 Ccr4 Ccr3 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260211%WP6%MUS MUSCULUS Integrin mediated cell adhesion Akt1 Pxn Mapk1 Ilk Cav1 Braf Rac3 Sos1 Itgb2 Mapk7 Pak6 Mapk6 Mapk4 Akt2 Map2k1 Tns1 Mylk2 Sorbs1 Tln1 Grb2 Vcl Vasp Arhgef7 Hras Shc3 Itga7 Itga8 Itga5 Itgb6 Itga6 Itga9 Itga3 Itga4 Itga1 Itga2 Capn9 Akt3 Itga10 Itga11 Pak4 Capn5 Cav3 Cav2 Capn7 Capn6 Capn3 Itgax Araf Itgav Pdpk1 Rac2 Itgae Ptk2 Itgal Vav3 Rap1a Rap1b Itgad Itgb8 Itgb7 Vav2 Itga2b Crk Itgb4 Itgb5 Actn1 Itgb3 Dock1 Map2k6 Bcar1 Map2k5 Pak1 Rho Csk Pak2 Mapk12 Git2 Map2k3 Rapgef1 Zyx Capns1 Capn10 Capn11 Rac1 Raf1 Shc1 Fyn Itgb1 Map2k2 Selenop Pak3 Cdc42 Capn1 Capn2 Rock2 Rock1 Pik3r2 Mapk10 Src Itgam ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260211%WP240%MUS MUSCULUS Alanine and aspartate metabolism Gad1 Got1 Got2 Gad2 Gpt Abat Ass1 Carns1 Asl Aspa Agxt Adsl Dars1 Pcx Crat BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260211%WP522%MUS MUSCULUS Biogenic amine synthesis Gad1 Chat Gad2 Ddc Aanat Tph1 Maoa Pnmt Hdc Asmt Dbh Pah Th Ache Comt EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260211%WP544%MUS MUSCULUS Exercise induced circadian regulation Bmal1 Gstm3 Herpud1 Ppp1r3c Nckap1 Gfra1 Vapa Ugp2 Sumo1 Sf3a3 Pigf Erc2 Dazap2 Qki Cldn5 Ppp2cb Eif4g2 H2bc7 Nr1d1 Cbx3 H2-DMa Rbpms Zfr Etv6 Hspa8 Per1 Pura Nr1d2 Gstp2 Klf9 Tab2 Tubb4a Azin1 Ncoa4 Myf6 Ucp3 Psma4 Idi1 Btg1 Dnaja1 Sumo3 Cry1 Cebpb Cry2 Stbd1 G0s2 Clock Tob1 COMPLEMENT ACTIVATION CLASSICAL PATHWAY%WIKIPATHWAYS_20260211%WP200%MUS MUSCULUS Complement activation classical pathway C2 C3 C4a C5 C1s1 C6 C7 C9 Cd55 C1qc C1qb C1qa C1ra Masp1 C8b C8a SPINAL CORD INJURY%WIKIPATHWAYS_20260211%WP2432%MUS MUSCULUS Spinal cord injury Gdnf Ccr2 Mapk1 Ccl2 Nos2 Il2 Fos Tacr1 Il4 Ifng Tlr4 Ccnd1 Fkbp1a Mapk3 Bdnf Myc Mbp Grin1 Mag Prkca E2f1 Ppp3ca Sox9 Ltb Pla2g2a Gfap Pla2g6 Icam1 Rhob C5 Aqp4 Col2a1 Pdyn Gja1 Nr4a1 Zfp36 Omg Pirb Plxna2 Anxa1 Ngfr Prb1a Klk8 Rtn4 Selp Bcan Chst11 Egr1 Efnb2 Ptpra Col4a1 Cspg4 Nox4 Ltb4r1 Btg2 Nos1 Ptprz1 Slit1 Slit3 Rhoc Rgma Vcan Sema6a Mmp12 Tnfsf13b Gap43 Arg1 Mmp9 Epha4 Rtn4r Ccng1 Ntn1 Tnfsf13 Pla2g5 Cd47 Cxcl1 Cxcl2 Ncan Fcgr2b Gadd45a Acan Il1a Xylt1 Tgfb1 Vim Il1r1 Casp3 Il1b Rb1 Rock2 Trp53 Cxcl10 Cdk4 Cdk2 Cdk1 Slit2 Tnf Rhoa Il6 E2f5 ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP435%MUS MUSCULUS One carbon metabolism Atic Mtr Mthfr Mthfd1l Dhfr Mtfmt Folh1 Tyms Mthfd1 Mthfd2 Ahcyl2 Ftcd Bhmt Gart Tcn2 Shmt2 Ehmt2 Dnmt3a Aldh1l1 Shmt1 Ehmt1 Mthfs Mat2b Ahcy Mtrr Amt Dnmt3b Dnmt1 Mat1a BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260211%WP460%MUS MUSCULUS Blood clotting cascade Fgb F8a1 Fga F10 Vwf F12 F11 F2 F5 Fgg F7 Plat F8 F9 F13b Plau Serpine1 Serpinf2 Serpinb2 Plg SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260211%WP1266%MUS MUSCULUS SIDS susceptibility pathways Slc6a4 Cc2d1a Avp Gata3 Tph2 Phox2a Nfkb1 Nfya Nkx3-1 Vipr2 Nr3c1 Foxm1 Adcyap1r1 Cdca7l Il6ra Vipr1 Tlx3 Ar Fev Chrna4 Gnb3 Ascl1 Rora C4a Hes1 Hes5 Ddc Ybx1 En1 Nkx2-2 Rest Ctcf Sp1 Cav3 Lmx1b Pou3f2 Htr1a Creb1 Gata2 Htr2a Ep300 Tph1 Maoa Ret Ppargc1a Il10 Phox2b Ppargc1b Ryr2 Deaf1 Scn5a Ece1 Adcyap1 Tnf Kcnh2 Chrnb4 Chrnb2 Il6 Kcnq1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260211%WP164%MUS MUSCULUS Glutathione metabolism Gstt1 Gss G6pdx Ggt5 Gpx2 Gpx1 Gpx4 Idh1 Gstt2 Gpx3 Gsr Anpep Chac2 Ggct Gstm2 Gstm7 Oplah Gsta1 Dpep1 Gclc Gclm Ggt1 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260211%WP207%MUS MUSCULUS Nucleotide GPCRs Adora2b Adora1 Adora2a Adora3 Lpar6 P2ry6 P2ry4 P2ry2 Tmigd3 P2ry1 Lpar4 Ltb4r1 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260211%WP1983%MUS MUSCULUS Splicing factor NOVA regulated synaptic proteins Mapk9 Camk2g Prkcz Rap1gap Kcnma1 Clasp1 Cask Dab1 Kcnj6 Epb41l2 Clstn1 Stxbp2 Mapk4 Epb41l3 Cdh2 Cadm3 Epb41l1 Cadm1 Gabbr2 Gabrg2 Kcnq2 Stx2 Grin2b Map4 Neo1 Plcb4 Agrn Atp2b1 Chl1 Ank3 Gphn Terf2ip Snw1 Ntng1 Epb41 Csn3 Aplp2 Grik2 Ncdn Efna5 Cav2 Grin1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP201%MUS MUSCULUS Ptf1a related regulatory pathway Fgf10 Ptf1a Nkx6-1 Rbpj Ctnnb1 Hes1 Kat2b Rbpjl Notch1 Pdx1 Prox1 DELTA NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP265%MUS MUSCULUS Delta Notch signaling pathway Akt1 Mapk1 Jak2 Rbpj Pik3r1 Hey2 Rela Ascl1 Ncor2 Notch4 Notch1 Jun Notch2 Notch3 Lck Dll1 Ncor1 Dll4 Hes1 Sin3a Mapk3 Hes5 App Snw1 Hdac2 Lef1 Adam17 Hdac1 Egf Skp2 Smad1 Adam10 Stat3 Fhl1 Hivep3 Mfng Hey1 Numb Egfr Ccn3 Psenen Cntf Sap30 Gsk3b Psen1 Mef2c Hes6 Spen Tle1 Psen2 Maml3 Zfpm1 Numbl Fbxw7 Ncstn Cntfr Pofut1 Aph1b Dtx1 Itch Maml1 Ep300 Maml2 Ring1 Furin Jag2 Jag1 Cirsr Nfkbia Magea1 Cntn1 Yy1 Lfng Wdr12 Skp1 Trp53 Pik3r2 Smad3 Smad4 Cdk2 Cul1 Tcf3 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260211%WP1270%MUS MUSCULUS Endochondral ossification Akt1 Vegfa Fgfr3 Igf1 Bmp7 Fgfr1 Ghr Prkaca Plat Thra Enpp1 Col2a1 Fgf2 Hdac4 Spp1 Chst11 Runx3 Runx2 Cdkn1c Stat1 Stat5b Mef2c Mmp9 Igf1r Acan Tgfb1 Ddr2 Fgf18 Ihh Ctsl Ptch1 Hmgcs1 Alpl Sox9 Col10a1 Sox5 Sox6 Adamts1 Mmp13 Ift88 Adamts5 Adamts4 Scin Frzb Pth1r Pth Nkx3-2 Plau Tgfb2 Cab39 Slc38a2 Pthlh Kif3a Serpinh1 Igf2 Gli3 Bmpr1a Timp3 Bmp6 Cst5 Mgp ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260211%WP396%MUS MUSCULUS ACE inhibitor pathway Ren1 Ren2 Ace Nos3 Kng1 Agtr2 Agt Bdkrb2 Agtr1a ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260211%WP4265%MUS MUSCULUS Ethanol metabolism resulting in production of ROS by CYP2E1 Nfe2l2 Map2k1 Maff Mafg Sp1 Prkcd Mafk Cyp2e1 Map2k2 Mapk8 EICOSANOID LIPID SYNTHESIS MAP%WIKIPATHWAYS_20260211%WP4335%MUS MUSCULUS Eicosanoid lipid synthesis map Pla2g6 Pla2g5 Ptgs2 Alox5 Ptges Pgs1 Ptgds Pla2g4b Pla2g4a OXIDATIVE STRESS AND REDOX PATHWAY%WIKIPATHWAYS_20260211%WP4466%MUS MUSCULUS Oxidative stress and redox pathway Gpx5 Ptgs2 Gstm3 Rac1 Ncf1 Ncf2 Gstp1 Ncf4 Slco1a1 G6pd2 Ggct Gls Gstm2 Grxcr2 Grxcr1 Gsta3 Prdx2 Gstp2 Gsta4 Slc6a5 Gsta1 Prdx3 Prdx4 Prdx5 Slc6a9 Prdx1 Gpx8 Gpx7 Pgd Abcc2 Gstm1 Abcc5 Gstt3 Foxp3 Gstt1 Lap3 Ctla4 Nrf1 Slc7a11 Txn Gss Slco2a1 G6pdx Gstm6 Slc1a2 Ggt5 Slc1a5 Prdx6b Prdx6 Idh1 S100a9 S100a8 Cd44 Anpep Ggt7 Ggt6 Idh2 Sod3 Sod2 Oplah Sod1 Hpgds Cyba Txnrd3 Cybb Gstk1 Gpx2 Gpx1 Gpx4 Gstt2 Gpx3 Gpx6 Gsr Gstm7 Txnrd1 Gstm5 Txnrd2 Cbs Gstm4 Gsta2 Nfe2l2 Alox5 Gsto1 Gclc Mgst3 Gsto2 Keap1 Gclm Mgst2 Mgst1 Ptgs1 Ggt1 STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260211%WP216%MUS MUSCULUS Striated muscle contraction Tnnc1 Tcap Dmd Actg1 Acta1 Acta2 Jsrp1 Actc1 Tpm4 Smpx Tpm3 Tpm2 Tpm1 Neb Tnni3 Tnni2 Tnni1 Myl4 Myom1 Des Myh3 Actn2 Mybpc1 Actn3 Mybpc2 Myl2 Mybpc3 Vim Myl3 Myh8 Actn4 Myh4 Myl9 Myom2 Myh6 Myh7 Myh1 Myl1 Tnnt3 Tnnt2 Tnnt1 Casq2 Ttn Tnnc2 Tmod1 HEART DEVELOPMENT%WIKIPATHWAYS_20260211%WP2067%MUS MUSCULUS Heart development Fgf10 Vegfa Mapk1 Hey1 Mef2c Hey2 Ptpn11 Hand1 Notch1 Bhlhe40 Srf Fgf8 Tbx10 Shh Smyd1 Nkx2-5 Bmp10 Nfatc4 Nfatc1 Hand2 Vegfc Nfatc3 Vegfb Nfatc2 Tbx20 Isl1 Irx4 Erbb3 Tbx5 Pitx2 Tbx2 Foxh1 Bmpr2 Smad4 Bmp2 Gata6 Gata4 Ctnnb1 Bmpr1a Foxc2 Smad1 Bmp4 Foxa2 Foxc1 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260211%WP1258%MUS MUSCULUS Homologous recombination Rpa1 Pold2 Pold1 Pold4 Pold3 Rad51 Rad50 Rad52 Brca2 Nbn Atm Mre11a Rad54b EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260211%WP4347%MUS MUSCULUS Eicosanoid metabolism via cyclooxygenases COX Cyp4a12a Pla2g6 Cyp4f14 Ptgs2 Ptgfr Cyp4a12b Ptgdr2 Cyp4a10 Ptgr2 Ptgr1 Acox1 Acox2 Acox3 Pla2g4b Ptgir Pla2g4a Acaa1a Pla2g5 Cyp4f3 Ppard Tbxas1 Prxl2b Hpgd Ptges Ptgds Akr1b1 Ptgis Tbxa2r Ehhadh Ptgs1 Ptgdr EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP1249%MUS MUSCULUS EPO receptor signaling Stat3 Akt1 Mapk1 Jak2 Stat1 Pdk1 Stat5b Stat5a Raf1 Epo Shc1 Rasa1 Epor Ptpru Ptprc Sos1 Pik3cg Map2k2 Cish Map2k1 Mapk3 Grb2 Src Socs1 Irs1 Irs2 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260211%WP385%MUS MUSCULUS Myometrial relaxation and contraction pathways Nfkb1 Ywhah Gnb3 Fos Atf1 Prkd1 Rgs4 Rgs5 Rgs2 Rgs3 Gnas Rgs1 Crcp Slc8a1 Rgs9 Rgs6 Gngt1 Oxtr Rgs7 Jun Plcg2 Prkcq Actb Prkcg Prkch Prkce Rxfp2 Rxfp1 Atf5 Gnb1 Mylk2 Atf4 Atf3 Calm3 Pkib Calca Grk5 Atf6b Grk4 Pkia Grk6 Sfn Pkig Cnn1 Dgkz Gnb2 Gnb4 Camk2a Gabpb1 Sp1 Rln1 Gnb5 Gng11 Gng12 Gng13 Plcg1 Ryr1 Ywhaq Oxt Creb1 Adm Ramp1 Gabpa Igfbp3 Ywhae Igfbp2 Ywhab Igfbp5 Guca2b Igfbp4 Guca2a Igfbp1 Lpar1 Creb3 Cald1 Prkacb Igfbp6 Ywhaz Prkca Prkar1a Prkar1b Rgs20 Plcd1 Rgs17 Rgs18 Rgs19 Prkcb Gng3 Crh Gng2 Gng5 Gng4 Crhr1 Rgs14 Gng7 Rgs16 Gng8 Cacnb3 Prkar2a Prkar2b Adcy3 Ackr3 Adcy4 Rgs10 Rgs11 Adcy1 Ackr5 Adcy2 Corin Adcy7 Ramp3 Ramp2 Adcy8 Adcy5 Adcy6 Adcy9 Pde4b Ets2 Nos3 Maff Prkcd Camk2g Camk2d Camk2b Arrb2 Arrb1 Prkcz Pde4d Gja1 Plcb3 Ywhag Atp2a3 Atp2a2 Ryr3 Nos1 Actg1 Acta1 Actc1 Myl4 Gnaq Myl2 Il1b Itpr3 Itpr2 Itpr1 Atf2 Gsto1 Ryr2 Il6 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP407%MUS MUSCULUS Kit receptor signaling pathway Fes Crkl Akt1 Mapk1 Jak2 Vav1 Pik3r1 Raf1 Shc1 Rasa1 Ptpn6 Epor Ptpru Cblb Cbl Sos1 Ptpn11 Pik3cg Fyn Lyn Cish Map2k1 Grb2 Hras Bad Plcg1 Stat3 Stat1 Stat5b Stat5a Vav2 Prkca Crk Prkcb Ep300 Mitf Abl1 Stap1 Grb10 Socs5 Socs4 Socs6 Matk Csf2rb Cltc Sh3kbp1 Pik3r2 Fgr Hck Dok1 Rps6ka1 Tnfrsf10b Kit Btk Spred1 Mpdz Src Spred2 Socs1 Inpp5d Grb7 Grap Yes1 Kitlg Plce1 Sh2b2 Tec ALPHA 6 BETA 4 INTEGRIN SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP488%MUS MUSCULUS Alpha 6 beta 4 integrin signaling pathway Clca1 Clca2 Akt1 Rpsa Erbin Rac1 Plec Dsp Mmp7 Dst Prkcd Cd151 Ywhah Lama1 Lama2 Pik3r1 Pik3ca Lama3 Trp73 Ar Mst1r Shc1 Met Col17a1 Lamb3 Pik3cg Lamb2 Fyn Lamb1 Lama5 Lamc1 Lamc2 Grb2 Erbb2 Eif4ebp1 Itga6 Sfn Mtor Bad Smad2 Ywhae Ywhab Ptk2 Egfr Ywhaz Prkca Itgb4 Ntn1 Pak1 Pik3cb Pik3cd Vim Eif6 Rtkn Abl1 Casp3 Eif4e Pik3r2 Smad3 Src Irs1 Irs2 Yes1 Rhoa Cdkn1a G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260211%WP232%MUS MUSCULUS G protein signaling pathways Prkcd Prkaca Gnb3 Prkd3 Prkd1 Akap7 Akap8 Akap5 Kras Akap6 Akap3 Gnas Prkcz Akap4 Pde7b Gnaz Pde7a Akap10 Akap11 Akap12 Gngt1 Akap9 Akap13 Prkcq Kcnj3 Nras Prkcg Prkci Prkch Rras Pde4c Prkce Gnai2 Pde4d Gnai1 Gnai3 Gna12 Gnb1 Gna11 Gng10 Gna15 Gna14 Gnao1 Gnal Hras Slc9a1 Gngt2 Plcb3 Pde8a Gnb2 Pde8b Gnb5 Gng11 Gng12 Gng13 Prkacb Prkca Prkar1a Prkar1b Gna13 Ppp3ca Arhgef1 Pde1b Pde1c Pde1a Prkcb Gng3 Gng5 Gng4 Gnaq Gng7 Gng8 Prkar2a Prkar2b Adcy3 Ppp3cc Adcy4 Adcy1 Adcy2 Adcy7 Akap1 Adcy8 Adcy5 Adcy6 Adcy9 Itpr1 Pde4a Pde4b Rhoa BURN WOUND HEALING%WIKIPATHWAYS_20260211%WP5056%MUS MUSCULUS Burn wound healing Nos3 Vegfa Acta1 Lama1 Gja1 Nos2 Flii Nlrp3 Tgfbrap1 Pecam1 Prodh2 Hbegf Tgfb1 Tnf Col1a1 ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP1264%MUS MUSCULUS Estrogen metabolism Cyp1b1 Sult1a1 Cyp1a2 Sult1e1 Ugt1a1 Cyp1a1 Nqo1 Ugt1a6 Ugt1a9 Ugt1a2 Gsta1 Gstm1 Comt MIR 127 IN MESENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP3991%MUS MUSCULUS miR 127 in mesendoderm differentiation Smad4 Acvr1 Nodal T Acvr2a Cfc1 T2 Lefty2 Smad2 Foxa2 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260211%WP553%MUS MUSCULUS Calcium regulation in cardiac cells Ywhah Gnb3 Calr Prkd1 Rgs4 Rgs5 Rgs2 Rgs3 Gnas Rgs1 Slc8a1 Rgs9 Rgs6 Gngt1 Rgs7 Prkcq Prkcg Prkch Prkce Gnb1 Fkbp1a Calm3 Pkib Grk5 Grk4 Pkia Atp2b1 Grk6 Sfn Pkig Gnb2 Gnb4 Camk2a Gnb5 Gng11 Gng12 Gng13 Ryr1 Ywhaq Ywhae Ywhab Prkacb Ywhaz Prkca Prkar1a Prkar1b Rgs20 Rgs17 Rgs18 Rgs19 Prkcb Gng3 Gng2 Gng5 Gng4 Rgs14 Gng7 Rgs16 Gng8 Cacnb3 Prkar2a Prkar2b Adcy3 Adcy4 Rgs10 Rgs11 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adrb2 Adrb1 Adcy9 Prkcd Gjb1 Camk2g Camk2d Camk2b Arrb2 Arrb1 Prkcz Gnaz Kcnj3 Gnai2 Gnai1 Gnai3 Gna11 Gnao1 Gja1 Plcb3 Cacna1c Ywhag Cacna1d Atp2a3 Atp2a2 Cacna1e Ryr3 Cacna1a Casq2 Cacna1b Cacna1s Gja3 Gja5 Gja4 Gja8 Slc8a3 Adra1b Adra1a Adrb3 Adra1d Fxyd2 Gjc1 Chrm1 Chrm3 Chrm2 Gjc2 Chrm5 Chrm4 Gjb2 Gjb4 Gjb3 Gjb6 Gjb5 Casq1 Atp2b2 Atp2b3 Gnaq Gjd2 Camk4 Atp1a4 Anxa6 Camk1 Kcnb1 Kcnj5 Pln Atp1b1 Cacnb1 Atp1b3 Atp1b2 Itpr3 Itpr2 Itpr1 Ryr2 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP493%MUS MUSCULUS Mapk signaling pathway Traf2 Ecsit Akt1 Tmem37 Mapk9 Ngf Mapk1 Rps6ka3 Nfkb1 Mink1 Braf Sos2 Elk1 Ppm1b Acvr1c Ppm1a Ptpn7 Ptpn5 Ntf4 Dusp5 Rasa1 Prkaca Dusp4 Fos Dusp1 Acvr1b Dusp7 Dusp10 Dusp6 Mapk13 Taok2 Taok1 Casp6 Casp2 Hspa1a Gck Cd14 Mapkapk5 Mos Map2k4 Jun Ntrk1 Mapk14 Mapk8ip3 Il1r2 Map3k11 Prkcg Map3k12 Mapk7 Prkch Map3k13 Mapk6 Map3k14 Mapk4 Akt2 Casp1 Map2k1 Atf4 Mapk3 Grb2 Bdnf Mapk8 Fgf4 Map2k7 Myc Akt3 Nf1 Egf Rac2 Tgfbr1 Egfr Rap1a Tgfbr2 Rap1b Mef2c Crk Ppp3ca Prkcb Map2k6 Map2k5 Pak1 Pak2 Mapk12 Map3k7 Nlk Tgfb2 Crkl Rac1 Prkcd Raf1 Arrb2 Arrb1 Hspa8 Kras Prkcz Tab2 Mapkapk2 Map2k2 Nras Gna12 Nr4a1 Mapt Ddit3 Cdc25b Ppp3r2 Pla2g5 Map3k4 Ppp3r1 Gadd45a Il1a Tgfb1 Cdc42 Il1r1 Casp8 Casp7 Ppp3cc Ppp3cb Casp9 Casp3 Map3k8 Srf Map3k6 Map3k5 Il1b Map3k20 Fas Map3k1 Pla2g10 Rasgrp4 Rasgrp1 Jund Trp53 Rasa2 Atf2 Max Stmn1 Mapk10 Stk3 Map4k4 Map4k3 Tgfb3 Fasl Ikbkb Pdgfrb Hspb1 Hspb2 Pdgfb Rasgrf2 Traf6 Map4k1 Hspa5 Ikbkg Flna Tab1 Tnf Daxx Ppp5c Ptprr Mras MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP1560%MUS MUSCULUS MicroRNAs in cardiomyocyte hypertrophy Akt1 Mapk1 Nfkb1 Rac1 Agt Igf1 Lrp6 Fgfr2 Lrp5 Pik3r1 Pik3ca Raf1 Camk2d Hdac9 Pik3cg Il6st Myef2 Fzd1 Fzd2 Chuk Map2k4 Map2k2 Mapk14 Cish Mapk7 Map3k14 Rcan1 Mapk4 Cdk7 Ikbke Akt2 Map2k1 Edn1 Mylk3 Prkg1 Mapk3 Mylk Nppb Nppa Ctf1 Mapk8 Fgf2 Map2k7 Mtor Hdac5 Hdac4 Plcb2 Hdac7 Egf Lif Stat3 Pdpk1 Nrg1 Gsk3b Cdk9 Ppp3ca Igf1r Eif2b5 Prkcb Map2k6 Map2k5 Pik3cb Pik3cd Tgfb1 Map2k3 Ppp3cb Wnt5a Nfatc4 Rock2 Rock1 Pik3r2 Ikbkb Pla2g2a Gata4 Ctnnb1 Ikbkg Tab1 Tnf Wnt3a Rhoa Dvl1 FOCAL ADHESION%WIKIPATHWAYS_20260211%WP85%MUS MUSCULUS Focal adhesion Akt1 Pxn Mapk9 Mapk1 Ilk Cav1 Braf Elk1 Igf1 Fn1 Pik3ca Rac3 Vtn Sos1 Lamb2 Itgb2 Lamb1 Col1a2 Col3a1 Col1a1 Jun Lama5 Actb Ccnd1 Mapk7 Pak6 Mapk6 Mapk4 Lamc1 Akt2 Map2k1 Lamc2 Thbs1 Pten Mylk2 Thbs3 Bcl2 Tln1 Mylk Grb2 Vcl Vasp Mapk8 Tnc Shc3 Erbb2 Ppp1r12a Itga7 Tnn Itga8 Tnr Itga5 Itgb6 Tnxb Itga6 Col5a2 Itga9 Col5a3 Itga3 Hgf Itga4 Col5a1 Pgf Itga2 Arhgap5 Spp1 Akt3 Myl6 Itga10 Reln Itga11 Pak4 Lama4 Thbs2 Cav3 Bad Thbs4 Cav2 Egf Blk Srms Txk Pdgfc Itgax Araf Pdgfd Itgav Chad Pdpk1 Pdgfra Rac2 Pdgfa Itgae Col4a4 Ptk2 Itgal Egfr Tesk2 Tnk1 Rap1a Col4a2 Rap1b Ptk6 Itgad Col4a6 Itgb8 Ibsp Itgb7 Pik3r5 Parvb Pelo Itga2b Crk Flt1 Itgb4 Birc3 Itgb5 Birc2 Actn1 Itgb3 Pik3r4 Col11a1 Dock1 Map2k6 Vegfd Bcar1 Pak5 Map2k5 Col6a2 Pak1 Farp2 Lamc3 Styk1 Pak2 Pip5k1c Mapk12 Map2k3 Rapgef1 Zyx Fgr Hck Crkl Vegfa Rac1 Vav1 Lama1 Lama2 Pik3r1 Lama3 Raf1 Shc1 Met Rhob Lamb3 Pik3cg Fyn Itgb1 Map2k2 Col11a2 Col2a1 Col4a1 Actg1 Selenop Gsk3b Pak3 Pik3cb Pik3cd Cdc42 Diaph1 Tnk2 Capn1 Ccnd2 Rock2 Ccnd3 Vegfc Vwf Rock1 Vegfb Pik3r2 Pdgfrb Src Pdgfb Flna Rhoa Itgam HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP193%MUS MUSCULUS Hepatocyte growth factor receptor signaling Stat3 Crkl Pxn Mapk1 Ptk2 Elk1 Rap1a Rap1b Pik3ca Raf1 Crk Rasa1 Fos Met Dock1 Ptpn11 Sos1 Pak1 Ptk2b Itgb1 Map2k2 Jun Rapgef1 Map2k1 Pten Mapk3 Grb2 Hras Mapk8 Hgf Itga1 Src Map4k1 Gab1 IL 7 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP297%MUS MUSCULUS IL 7 signaling pathway Stat3 Akt1 Jak3 Foxo3 Mapk1 Stat1 Stam2 Stat5b Stat5a Gsk3b Pik3r1 Raf1 Shc1 Stam Cbl Cblb Sos1 Fyn Lyn Bcl2l11 Ptk2b Muc1 Mcl1 Map2k2 Irf1 Bax Il7r Il2rg Map2k1 Rb1 Ccnd2 Mapk3 Grb2 Cltc Jak1 Hras Ccna2 Cdk4 Cdk2 Irs1 Irs2 Bad Blk Foxo1 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1496%MUS MUSCULUS Oxidative damage response Traf2 Nfkb1 Pcna Apaf1 Tnfrsf1b C5ar1 Mapk13 Gadd45a C1qb C1qa Cdc42 C1ra Map2k4 Tnk2 Cr2 C2 Casp9 Traf3 Casp3 Map3k9 C5 Bag4 Bak1 C1s1 Traf1 Nfkbie Cycs Map3k1 Bcl2 Cyct Tdp2 C1qc Mapk10 C3ar1 Traf6 Bad Tnf Cdkn1a Cdkn1b Cdkn1c MIR 193A AND MVP IN COLON CANCER METASTASIS%WIKIPATHWAYS_20260211%WP3979%MUS MUSCULUS mir 193a and MVP in colon cancer metastasis Ccnd1 Myc Ccnd2 Mvp Caprin1 G3bp1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260211%WP2573%MUS MUSCULUS Primary focal segmental glomerulosclerosis FSGS Cldn1 Col4a5 Akt1 Synpo Lims1 Kirrel2 Ilk Kirrel3 Fat1 Parva Lrp6 Cd151 Lrp5 Camk2b Vtn Lamb2 Fyn Itgb1 Tlr4 Notch1 Cd80 Lama5 Tln1 Vcl Agrn Itga3 Nck1 Lmx1b Plcg1 Ywhaq Cdkn1c Itgav Mme Col4a3 Pcna Col4a4 Ptk2 Itgb4 Itgb3 Tgfb1 Jag1 Vim Actn4 Dkk1 Cdh2 Ctsl Mki67 Cr1l Trpc6 Utrn Ptpro Nphs2 Nphs1 Cd2ap Dag1 Krt8 Dnm1 Ctnnb1 Scarb2 Inf2 Pax2 Myh9 Irf6 Plaur Podxl Myo1e Plce1 Cdkn1a Smarcal1 Wt1 Cdkn1b TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260211%WP79%MUS MUSCULUS Tryptophan metabolism Cyp1b1 Ube3a Cyp4f14 Aldh1a2 Aldh3a2 Hadh Aldh2 Aldh9a1 Cyp1a1 Wars1 Tdo2 Cyp2j6 Cyp2c55 Aadat Ubr5 Aox1 Ogdh Afmid Gcdh Maob Cyp19a1 Aoc1 Acat1 Dhcr24 Haao Echs1 Cat Kynu Prmt1 Cyp2f2 Rnf25 Acmsd Ido1 Cyp1a2 Cyp2e1 Ddc Aanat Tph1 Aldh1a1 Inmt Asmt Mdm2 Hsd17b10 Cyp7b1 HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP116%MUS MUSCULUS Hedgehog signaling pathway Stk36 Ptch2 Sap18 Crebbp Sufu Ccnb1 Ihh Shh Dyrk1a Ptch1 Gas1 Sin3a Gli2 Smo Cdk1 Igf2 Gli3 Rab23 Dhh Gli1 Hhip IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP373%MUS MUSCULUS IL 3 signaling pathway Akt1 Pxn Mapk9 Mapk1 Nfkb1 Pik3ca Syk Prkaca Tnfrsf1b Atf1 Sos1 Mapk14 Lck Mapk7 Map2k1 Bcl2 Mapk3 Grb2 Vcl Jak1 Hras Mapk8 Bad Gab1 Creb1 Stat3 Rac2 Ywhab Stat1 Ptk2 Rap1a Stat5a Ywhaz Prkca Crk Prkcb Pak1 Bcl2l11 Rapgef1 Bax Ppp2ca Matk Csf2rb Hck Dnm1 Inpp5d Socs3 Id1 Tec Fes Crkl Jak2 Rac1 Gab2 Rack1 Vav1 Pik3r1 Raf1 Shc1 Ptpn6 Rara Cbl Ptpn11 Kras Fyn Lyn Mapkapk2 Cish Rxra Spi1 Socs2 Fcer2a Gata1 Il3ra Il3 Rps6kb2 Bmx Stat6 Birc5 Kcnip3 Slc2a1 Tyk2 Mmp2 Bcl2l1 Gsk3a Selp Foxo1 Stat5b Gsk3b Mmp9 Gata2 Chek1 Pik3cd Cdc42 Atf2 Pik3r2 Hspb1 Src Mras GLOBO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5305%MUS MUSCULUS Globo series sphingolipid metabolism B3galnt1 B3galt5 Fut2 Gbgt1 MIR302 367 PROMOTING CARDIOMYOCYTE PROLIFERATION%WIKIPATHWAYS_20260211%WP2904%MUS MUSCULUS miR302 367 promoting cardiomyocyte proliferation Yap1 Mob1b Lats2 Mst1 IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP387%MUS MUSCULUS IL 6 signaling pathway Akt1 Pxn Mapk1 Nfkb1 Il6ra Fos Sos1 Il6st Cd40 Map2k4 Jun Ncoa1 Mapk14 Crebbp Map2k1 Mapk3 Grb2 Jak1 Hras Mapk8 Erbb2 Erbb3 Eif4ebp1 Bad Plcg1 Gab1 Stat3 Stat1 Ptk2 Stat5a Cdk9 Map2k6 Map3k7 Ppp2ca Eif4e Nlk Fgr Hck Btk Inpp5d Socs3 Tec Hsp90aa1 Fes Foxo3 Jak2 Rac1 Gab2 Prkcd Vav1 Ppp2cb Pik3r1 Raf1 Ar Shc1 Ptpn11 Fyn Lyn Mapkapk2 Ptk2b Map2k2 Bmx Tyk2 Hdac1 Cebpb Ppp2r3a Foxo1 Ppp2r2c Ppp2r2b Mapt Ptpa Ppp2r2a Ppp2r1b Ppp2r1a Hnf1a Cdk5r1 Foxo4 Stat5b Rps6ka2 Sgk1 Gsk3b Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Inppl1 Eif2a Ppp2r5e Map3k4 Rps6kb1 Ep300 Casp9 Casp3 Cdk5 Rb1 Pik3r2 Hspb1 Daxx Il6 HYPOXIA DEPENDENT PROLIFERATION OF MYOBLASTS%WIKIPATHWAYS_20260211%WP5024%MUS MUSCULUS Hypoxia dependent proliferation of myoblasts Akt1 Vegfa Myf5 Igf1 Mstn Calca Trim63 Fbxo32 Smad3 Ddit4 Myod1 Tsc2 Hgf Tsc1 Fgf1 Mtor Rheb Smad2 Myog APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260211%WP166%MUS MUSCULUS Apoptosis modulation by HSP70 Casp9 Casp3 Nfkb1 Fas Map3k1 Apaf1 Fadd Mapk10 Tnfrsf1a Casp6 Aifm1 Casp2 Ripk1 Hspa1a Bid Casp8 Casp7 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP449%MUS MUSCULUS Complement and coagulation cascades Kng1 Fgb Plat C5ar1 Bdkrb1 C1qb C1qa C1ra Masp1 C2 C3 C5 C1s1 C6 C7 C9 Cd55 C1qc Serpine1 Serping1 Mbl1 C4bpa Masp2 Tfpi Cfb F3 Serpina5 Cr2 C8g Cfd Cd59a Cfh F2r Cfi Klkb1 Proc Serpind1 Cd46 F10 Thbd Vwf Pros1 F12 Serpinc1 Cr1l F11 A2m F2 Cpb2 F5 Cd55b F7 F8 F9 F13b Plau Serpinf2 C3ar1 Plaur Plg ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260211%WP1770%MUS MUSCULUS One carbon metabolism and related pathways Gpx5 Baat Gpx7 Bhmt Shmt2 Dnmt3a Shmt1 Gss Chdh Cth Sod3 Mat1a Sod2 Sod1 Gad1 Pld1 Gpx2 Gpx1 Gpx4 Gpx3 Gpx6 Gsr Mtr Cbs Mthfr Chkb Dhfr Pcyt1a Tyms Pemt Gad2 Chka Bcat1 Bcat2 Pcyt1b Pcyt2 Csad Dmgdh Bhmt2 Dnm1 Cept1 Gclc Mat2a Gnmt Ahcyl1 Gclm Etnk2 Etnk1 Chpt1 Agxt2 Sardh Cdo1 GENE REGULATORY NETWORK MODELLING SOMITOGENESIS %WIKIPATHWAYS_20260211%WP2852%MUS MUSCULUS Gene regulatory network modelling somitogenesis Mesp2 Lfng Hes7 Ripply2 Fgf8 Dll1 Hes1 Epha4 Wnt3a Notch1 Tbx6 GLYCOGEN METABOLISM%WIKIPATHWAYS_20260211%WP317%MUS MUSCULUS Glycogen metabolism Ppp2r2b Ptpa Ppp2r2a Gbe1 Ppp2r1b Phkb Ppp2r1a Gys1 Gys2 Ugp2 Phka1 Phka2 Ppp2r5d Gyg1 Gsk3b Ppp2r5c Pygb Ppp2r5b Ppp2cb Phkg1 Ppp2r5a Phkg2 Agl Pygl Pygm Ppp2r5e Calm2 Ppp2ca Pgm1 Calm3 Gsk3a Ppp2r3a Ppp2r2c BMP SIGNALING PATHWAY IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260211%WP3663%MUS MUSCULUS BMP signaling pathway in eyelid development Fgf10 Mapk9 Sfrp1 Shh Egfr Smad5 Map3k1 Mapk3 Fgfr2 Dkk2 Pitx2 Inhbb Smad4 Foxc2 Jun Smad1 Bmp4 Notch1 Tgfa Foxc1 IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP37%MUS MUSCULUS IL 1 signaling pathway Akt1 Irak4 Mapk1 Nfkb1 Irak2 Irak1 Il1rap Peli1 Ptpn11 Myd88 Sqstm1 Rela Irak3 Nfkbib Prkcz Tollip Tab2 Elp1 Il1a Sirpa Il1rn Chuk Il1r1 Nfkbia Map3k7 Il1r2 Capns1 Capn1 Map3k14 Casp1 Map2k1 Il1b Mapk3 Mapk8 Traf6 Tab1 Plcg1 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP18%MUS MUSCULUS Heme biosynthesis Cpox Uros Urod Ppox Alad Alas1 Alas2 Hmbs Fech AMINO ACID METABOLISM%WIKIPATHWAYS_20260211%WP662%MUS MUSCULUS Amino acid metabolism Pkm Hadh Wars1 Acaa1a Tdo2 Gls Ogdh Gsta4 Lars2 Bhmt Pdhx Tat Asns Gss Aldh7a1 Vars1 Acss1 Farsb Cs Ddc Suclg1 Idh1 Aldh1a1 Pdk4 Hibch Sds Arg2 Aldh18a1 Gpt2 Cth Cad Th Dlst Mccc1 Ldha Mars2 Sms Mpst Oat Glud1 Pycr1 Odc1 Cps1 Adh7 Prodh Adh5 Srm Rars1 Adh4 Tpo Adh1 Pck1 Aoc3 Arg1 Fh Mdh1 Mdh2 Eprs1 Iars1 Fah Gsr Hal Pcx G6pc2 Ppm1l Hmgcl P4ha2 Hibadh Aco2 Hmgcs2 Mmut Acly Cbs Glul Otc Sdhd Auh Sdha Dld Pdha1 Got1 Got2 Ftcd Hnmt Ass1 Asl Tph1 Maoa Bcat1 Pnmt Hdc Dbh Gclm Ehhadh Acadm PDGFR ALPHA AND STMN1 COOPERATE TO EXACERBATE CYTOTOXIC EFFECTS OF VINBLASTINE%WIKIPATHWAYS_20260211%WP4398%MUS MUSCULUS PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine Pdgfra Stmn1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260211%WP2084%MUS MUSCULUS SREBF and miR33 in cholesterol and lipid homeostasis Ppara Ppargc1a Mtor Srebf2 Hmgcr Nr1h3 Sirt1 Ldlr Med15 Srebf1 Sirt6 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260211%WP3857%MUS MUSCULUS Wnt signaling in kidney disease Dvl3 Fzd3 Mapk9 Csnk1a1 Gsk3b Lrp5 Wnt7a Apc Fzd1 Fzd2 Fzd5 Fzd7 Fzd9 Wnt11 Lrp4 Wnt6 Wnt5a Wnt7b Wnt5b Wnt9b Wnt10a Invs Wnt2b Wnt16 Btrc Mapk8 Mapk10 Wnt2 Nlrp3 Wnt4 Wnt3 Axin1 Fzd4 Fzd6 Fzd8 Ctnnb1 Wnt1 Wnt3a Kitlg Rhoa Wnt10b Dvl1 Dvl2 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260211%WP4345%MUS MUSCULUS Glycerolipids and glycerophospholipids Pcyt1a Pld1 Pemt Cds1 Ptdss1 Gpat4 Plpp1 Pla2g1b Ptdss2 Pnpla3 Pisd Dgat2 Cdipt Gpam Pnpla2 Pcyt2 Dgat1 Dgkz Agpat4 Crls1 Etnk1 Chpt1 Chkb CIRCULATING MONOCYTES AND CARDIAC MACROPHAGES IN DIASTOLIC DYSFUNCTION%WIKIPATHWAYS_20260211%WP4474%MUS MUSCULUS Circulating monocytes and cardiac macrophages in diastolic dysfunction Ccr2 Ccl2 Il10 Spp1 SEROTONIN RECEPTOR 2 AND STAT3 SIGNALING%WIKIPATHWAYS_20260211%WP2079%MUS MUSCULUS Serotonin receptor 2 and STAT3 signaling Stat3 Jak2 Htr2a Gnaq MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260211%WP3626%MUS MUSCULUS Microglia pathogen phagocytosis pathway Lat Rac2 Rac1 Vav3 Vav1 Pik3ca Pik3r1 Syk Vav2 Ncf1 Rac3 Ncf2 Ncf4 Ptpn6 Pik3cg Fcer1g Pik3cb Lyn Itgb2 Pik3cd C1qb C1qa Plcg2 C1qc Pik3r2 Hck Pik3c3 Tyrobp Siglec12 Cyba Fcgr1 Cybb Nckap1l Pik3c2a Arpc1b Trem3 Trem2 Pik3r6 Itgam Trem1 ADIPOGENESIS GENES%WIKIPATHWAYS_20260211%WP447%MUS MUSCULUS Adipogenesis genes Gata3 Igf1 Il6st Ncor2 Ncoa2 Ncoa1 Ncor1 Cebpd Serpine1 Sp1 Wnt1 Lif Creb1 Stat3 Stat1 Pck1 Stat5a Mef2c E2f1 Cntfr Wnt5b Twist1 Pnpla3 Frzb Scd1 Socs1 Socs3 Irs1 Irs2 Ptgis Dvl1 Gh Nampt Ins2 Irs4 Trib3 Celf1 Agt Ahr Irs3 Lifr Nr3c1 Prlr Bscl2 Agrp Mif Retn Lmna Ndn Id3 Rara Cisd1 Pck2 Nsg1 Bmp3 Wwtr1 Bmp1 Hmga1 Fzd1 Plin1 Plin2 Ucp1 Adipoq Nr2f1 Nr1h3 Epas1 Slc2a4 Sfrp4 Ppard Rbl2 Rora Gadd45b Ppara Mef2d Zmpste24 Pparg Fabp4 Osm Lpin3 Rxra Lpin2 Lpin1 Dlk1 Rxrg Mixl1 Mef2a Klf7 Klf6 Mef2b Lep Stat6 Spock1 Stat2 Agpat2 Gdf10 Ins1 Cebpb Cebpa Cyp26b1 Wnt10b Foxo1 Tle3 Egr2 Ddit3 Ebf1 Hnf1a Stat5b Klf5 Cyp26a1 Rbl1 Klf15 Gata2 Srebf1 Lpl Gadd45a Mbnl1 Tgfb1 Lipe Cfd Hif1a Fas Rb1 Nrip1 Smad3 Bmp2 Ppargc1a Gata4 Ctnnb1 Tnf Foxc2 E2f4 Bmp4 Il6 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP350%MUS MUSCULUS p38 Mapk signaling pathway Traf2 Ddit3 Stat1 Rac1 Tgfbr1 Elk1 Pla2g4a Shc1 Map2k6 Ripk1 Mapkapk2 Cdc42 Map2k4 Mknk1 Mapk14 Map3k7 Mef2d Map3k9 Map3k5 Map3k1 Grb2 Hras Atf2 Max Hmgn1 Tradd Tgfb2 Rasgrf1 Hspb1 Rps6ka5 Myc Daxx Creb1 GPCRS SMALL LIGAND%WIKIPATHWAYS_20260211%WP353%MUS MUSCULUS GPCRs small ligand Ptgfr Cnr1 Lpar1 Ptgir S1pr1 S1pr2 Mtnr1b Mtnr1a Cnr2 Ptger4 Ptger2 Ptafr Ptger3 Ptger1 S1pr3 Tbxa2r S1pr4 Ptgdr OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260211%WP454%MUS MUSCULUS Osteoclast signaling Ctsk Ifnb1 Tnfsf11 Ifnar1 Atp6v1g1 Tnfrsf11b Tnfrsf11a Gpr68 Acp5 Slc9a1 Itgb3 Pdgfb Spp1 Trpv5 EBV LMP1 SIGNALING%WIKIPATHWAYS_20260211%WP1243%MUS MUSCULUS EBV LMP1 signaling Hsp90aa1 Ifnb1 Map3k14 Mapk1 Nfkb1 Traf1 Nfkb2 Pdlim7 Map3k3 Ccl20 Ccl5 Mapk8 Irak1 Ikbkb Tradd Rela Traf6 Ikbkg Chuk Tnf Map3k7 POLYOL PATHWAY%WIKIPATHWAYS_20260211%WP1265%MUS MUSCULUS Polyol pathway Akr1b1 Sord Aldob Khk APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260211%WP3592%MUS MUSCULUS ApoE and miR 146 in inflammation and atherosclerosis Rela Spi1 Nfkb2 Apoe Traf6 Tlr4 Irak1 Tlr2 REGULATION OF PGC1A EXPRESSION BY A GSK3B TFEB SIGNALING AXIS IN SKELETAL MUSCLE%WIKIPATHWAYS_20260211%WP4763%MUS MUSCULUS Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle Tfeb Ppargc1a Gsk3b EGFR1 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP572%MUS MUSCULUS EGFR1 signaling pathway Rbbp7 Eps15l1 Akt1 Pxn Reps2 Ralbp1 Mapk1 Rps6ka3 Ctnnd1 Abi1 Cav1 Sos2 Pebp1 Elk1 Pkn2 Zpr1 Pik3ca Ptpn5 Rasa1 Fos Dusp1 Atf1 Cblb Prkd1 Sos1 Appl1 Jun Plcg2 Mapk14 Mapk7 Map3k14 Map2k1 Mapk3 Grb2 Sin3a Tgif1 Jak1 Hras Mapk8 Map2k7 Camk2a Myc Sp1 Nck1 Eef1a1 Cav2 Egf Plcg1 Smad2 Gab1 Creb1 Cblc Stat3 Araf Pld1 Ywhab Stat1 Egfr Vav3 Stat5a Ptk6 Prkca Vav2 Prkar1a Crk Prkcb Bcar1 Itch Map2k5 Pak1 Csk Rgs16 Snrpd2 Map2k3 Grb10 Sh3kbp1 Rps6ka1 Krt8 Dnm1 Socs1 Socs3 Grb7 Crkl Jak2 Rac1 Plec Gab2 Vav1 Pik3r1 Raf1 Shc1 Ptpn6 Cbl Ptpn11 Pik3cg Kras Prkcz Ptk2b Map2k2 Nras Prkci Gja1 Stat2 Rps6ka5 Hdac1 Cebpb Cebpa Foxo1 Stat5b Rps6ka2 Map3k3 Snca Inppl1 Sh2d3c Grb14 Map3k4 Stxbp1 Elk4 Eps8 Ralb Krt7 Eps15 Pik3cb Ripk1 Map3k2 Pik3cd Dok2 Ap2a1 Cdc42 Hat1 Pitpna Rab5a Pld2 Tnk2 Errfi1 Casp9 Usp6nl Pik3c2b Wasl Ralgds Wnk1 Rfxank Arf4 Map3k1 Hip1 Sh3bgrl Shoc2 Ndufa13 Jund H3f4 Nck2 Asap1 Pik3r2 Git1 Sh3gl3 Smad3 Epn1 Elf3 Klf11 Sh3gl2 Plscr1 Ceacam1 Tnip1 Src Htt Appl2 Ptpn12 Mta2 Krt18 Krt17 Mcf2 Ptprr Reps1 Spry2 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260211%WP456%MUS MUSCULUS GPCRs class B secretin like Adgre5 Vipr2 Ghrhr Adcyap1r1 Gipr Adgrg2 Gcgr Vipr1 Adgre1 Adgrl2 Sctr Adgrl3 Adgrl4 Pth1r Adgrl1 Glp2r Pth2r Calcrl Glp1r Crhr2 Crhr1 Calcr DEREGULATION OF RENIN ANGIOTENSIN SYSTEM BY SARS COV INFECTION%WIKIPATHWAYS_20260211%WP4965%MUS MUSCULUS Deregulation of renin angiotensin system by SARS CoV infection Ace Agtr2 Ace2 Agtr1a WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260211%WP723%MUS MUSCULUS Wnt signaling pathway and pluripotency Mapk9 Ctnnd1 Nfya Prkd1 Pafah1b1 Ppp2r2d Pou5f1 Fosl1 Nanog Jun Hnf1b Zbtb33 Prkcq Fbxw2 Ccnd1 Nkd2 Prkcg Racgap1 Prkch Ppm1j Prkce Crebbp Sox2 Lef1 Myc Wnt1 Prkca Prkcb Ldlr Map3k7 Wnt11 Wnt5a Wnt6 Wnt7b Wnt5b Wnt9b Wnt10a Ppp2ca Wnt2b Wnt16 Nlk Foxd3 Wnt2 Wnt4 Axin1 Wnt3 Axin2 Fzd4 Fzd6 Fzd8 Wnt3a Dvl1 Dvl2 Dvl3 Ctbp1 Fzd3 Csnk1e Mmp7 Prkcd Lrp6 Lrp5 Ppp2cb Nkd1 Tcf4 Wnt7a Ctbp2 Apc Prkcz Fzd1 Frat1 Fzd2 Fzd5 Fzd7 Ppard Fzd9 Prkci Cd44 Tcf7l1 Wnt10b Ppp2r2c Ppp2r2b Ptpa Ppp2r2a Ppp2r1b Ppp2r1a Hnf1a Gsk3b Ppp2r5c Ppp2r5e Ep300 Ccnd2 Ccnd3 Trp53 Mapk10 Plau Ctnnb1 Rhoa LUNG FIBROSIS%WIKIPATHWAYS_20260211%WP3632%MUS MUSCULUS Lung fibrosis Ccr2 Ccl2 Dsp Igf1 Bmp7 Il4 Il5 Eln Il13 Fgf7 Ccn2 Edn1 Mecp2 Atp11a Parn Sftpa1 Fam13a Csf2 Calca Csf3 Mt2 Ccl11 Elmod2 Fgf2 Dpp9 Sftpc Ccl4 Mmp2 Ccl3 Hgf Skil Cma1 Muc5b Stn1 Spp1 Cysltr2 Timp1 Rtel1 Cebpb Ptx3 Cxcl15 Egf Tgfa Pdgfa Smad7 Mmp9 Ccl5 Cxcl2 Fgf1 Tgfb1 Il1b Grem1 Hmox1 Plau Nfe2l2 Pdgfb Il12b Tnf Il6 Ccr3 Tert PROTEASOME DEGRADATION%WIKIPATHWAYS_20260211%WP519%MUS MUSCULUS Proteasome degradation Ifng H2ax Psma3 Psma6 Psma5 Psme3 Psma2 Psma1 Psme2 Psme1 Psmd12 Psmd11 Psmd10 Ube2b Psmd13 Psmb10 Uchl4 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Ube2d3 Ube2d1 Psma7 Psmc6 Psmc5 Psmc2 Rpn2 Psmc1 Psmc4 Psmc3 Rpn1 Uba7 Ubb Ubc Psmb9 Psmb8 Psmd7 H2az1 Psmd6 Psmd9 Uchl1 Psmd8 Psmd3 Psmd2 Psmd5 Psmd4 Ube2d2a Uba1 Hist1h2an H2-Q10 Psma4 B CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP274%MUS MUSCULUS B cell receptor signaling pathway Akt1 Mapk1 Braf Sos2 Elk1 Zap70 Syk Rasa1 Dusp4 Ptprc Cblb Prkd1 Sos1 Dusp6 Rela Rel Chuk Jun Plcg2 Mapk14 Prkcq Lck Prkce Mapk4 Cdk7 Map2k1 Rps6 Bcl2 Mapk3 Grb2 Mapk8 Nck1 Plcg1 Blk Gab1 Creb1 Stat3 Pdpk1 Stat1 Ptk2 Bcl6 Vav2 Crk Ppp3ca Prkcb Bcar1 Csk Pip5k1c Bcl2l11 Nfkbia Rapgef1 Bax Map3k7 Cr2 Stap1 Hck Dok1 Cd72 Rps6ka1 Sla2 Chst15 Pdk2 Btk Cd81 Gtf2i Actr2 Actr3 Inpp5d Dok3 Rasgrp3 Arpc1b Pip4k2b Pip4k2c Cd79a Cd79b Sh2b2 Bcl10 Tec Pik3ap1 Crkl Arpc3 Arpc2 Cd19 Arpc5 Arpc4 Itk Gab2 Rap2a Prkcd Dapp1 Vav1 Bank1 Cd22 Atp2b4 Pik3r1 Raf1 Plekha2 Plekha1 Shc1 Hcls1 Card11 Ptpn6 Lat2 Blnk Lime1 Cbl Lcp2 Ptpn11 Pik3cg Ptpn18 Cd5 Fyn Sh3bp2 Cmtm3 Lyn Nedd9 Mapkapk2 Pip5k1b Ptk2b Pip5k1a Map2k2 Ccna2 Ccne1 Gsk3a Hdac5 Hdac7 Foxo1 Gsk3b Was Hnrnpk Ppp3r1 Rps6kb1 Fcgr2b Casp7 Ppp3cb Casp9 Rb1 Ccnd2 Ccnd3 Nfatc1 Itpr2 Nfatc3 Itpr1 Atf2 Nfatc2 Pik3r2 Pip4k2a Cdk6 Ikbkb Cdk4 Cdk2 Ctnnb1 Map4k1 Ikbkg Rhoa KENNEDY PATHWAY%WIKIPATHWAYS_20260211%WP1771%MUS MUSCULUS Kennedy pathway Pcyt1a Sgpl1 Pemt Chka Ptdss1 Ptdss2 Pisd Pcyt1b Pcyt2 Cept1 Etnk2 Etnk1 Chpt1 Chkb MONOAMINE GPCRS%WIKIPATHWAYS_20260211%WP570%MUS MUSCULUS Monoamine GPCRs Adra1b Adra1a Adrb3 Adra1d Chrm1 Chrm3 Chrm2 Chrm5 Chrm4 Drd1 Drd2 Htr2a Htr2c Drd5 Adra2a Adra2c Adra2b Htr4 Hrh1 Htr6 Htr7 Hrh2 Htr2b Drd3 Drd4 Htr1f Htr1b Htr5b Htr5a Adrb2 Adrb1 Htr1d Htr1a OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260211%WP238%MUS MUSCULUS Osteoblast signaling Pth1r Tnfsf11 Pth Pdgfra Tnfrsf11b Pdgfrb Bglap2 Slc17a2 Fgf23 Col1a1 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260211%WP1274%MUS MUSCULUS Oxidation by cytochrome P450 Cyp1b1 Cyp4x1 Cyp24a1 Cyp26a1 Cyp11b1 Cyp1a1 Cyp11b2 Cyp20a1 Cyp2w1 Cyp7a1 Cyp4f3 Cyp19a1 Cyp2s1 Cyp27b1 Cyp4f39 Cyp2f2 Cyp11a1 Cyp4b1 Cyp51a1 Cyp8b1 Cyp1a2 Cyp4v3 Cyp27a1 Cyp2r1 Cyp46a1 Cyp17a1 Cyp2e1 Cyb5r4 Cyb5r3 Cyb5r2 Cyb5r1 Cyp26c1 Cyb5a Cyb5b Cyp21a1 Cyp39a1 Por Cyp2u1 Cyp26b1 Cyp7b1 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260211%WP1242%MUS MUSCULUS Non homologous end joining Xrcc6 Xrcc5 Xrcc4 Nhej1 Rad50 Prkdc Mre11a PARKINSON 39 S DISEASE%WIKIPATHWAYS_20260211%WP3638%MUS MUSCULUS Parkinson 39 s disease Prkn Septin5 Gpr37 Ube2l6 Ube2j2 Ube2l3 Ube2j1 Mapk11 Apaf1 Park7 Eprs1 Snca Mapk13 Casp6 Casp2 Mapk12 Casp7 Uba7 Mapk14 Ubb Casp9 Casp3 Uchl1 Cycs Ddc Uba1 Ccne1 Ccne2 Th Atxn2 Pink1 Slc6a3 Syt11 Lrrk2 Htra2 Ube2g2 Ube2g1 Sncaip BDNF PATHWAY%WIKIPATHWAYS_20260211%WP2152%MUS MUSCULUS BDNF pathway Mapk4 Rac1 Bcl2 Frs2 Ntrk2 Bdnf Trp53 Shc1 Plat Ngfr Serpine1 Plg Cdc42 Bax Creb1 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY %WIKIPATHWAYS_20260211%WP4690%MUS MUSCULUS Sphingolipid metabolism integrated pathway Cers5 Lass1 Sptlc1 Sgpl1 Cerk Sptlc2 Smpd1 Degs2 Degs1 Cers6 Plpp3 Cers4 Cers3 Plpp1 Cers2 Asah1 Sphk2 Sgms1 Sphk1 Sgms2 Kdsr Sgpp2 Ugcg Ugt8 Sgpp1 LAC PHE PATHWAY%WIKIPATHWAYS_20260211%WP5240%MUS MUSCULUS Lac Phe pathway Abcc5 Cndp2 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260211%WP683%MUS MUSCULUS Leptin and adiponectin Lepr Cpt1a Adipoq Adipor2 Adipor1 Lep Prkab1 Prkaa1 Acaca Prkag1 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260211%WP2141%MUS MUSCULUS Serotonin and anxiety Adra1a Grm1 Ppp3ca Camk2b Plek Fos Plcd4 Pomc Arc Gabra1 Prkcb Trpv1 Crh Htr2a Htr2c Eef2 Fmr1 Htr1a EICOSANOID METABOLISM VIA LIPOXYGENASES LOX %WIKIPATHWAYS_20260211%WP4348%MUS MUSCULUS Eicosanoid metabolism via lipoxygenases LOX Cyp4a12a Cyp4f14 Ltc4s Cyp4a12b Cyp4a10 Ptgr2 Ptgr1 Acox1 Acox2 Acox3 Gpx1 Acaa1a Gpx4 Dpep2 Cyp4f3 Ggt5 Ephx2 Alox12 Alox5 Dpep1 Lta4h Mgst3 Alox15 Hpgd Mgst2 Ehhadh Ggt1 HYPOXIA DEPENDENT SELF RENEWAL OF MYOBLASTS%WIKIPATHWAYS_20260211%WP5023%MUS MUSCULUS Hypoxia dependent self renewal of myoblasts Myh1 Hif1a Hey1 Myf5 Hes1 Hey2 Myod1 Hsp90b1 Notch1 Cdkn1a Pax7 Foxo1 Myog CHOLESTEROL BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP103%MUS MUSCULUS Cholesterol biosynthesis Msmo1 Hmgcs1 Fdps Idi1 Nsdhl Mvk Dhcr7 Fdft1 Hmgcr Lss Sqle Pmvk Sc5d Cyp51a1 Mvd SIGNAL TRANSDUCTION OF S1P RECEPTOR%WIKIPATHWAYS_20260211%WP57%MUS MUSCULUS Signal transduction of S1P receptor Smpd2 Racgap1 Mapk7 Pik3c2g Akt1 Mapk6 Asah2 Gnai2 Mapk1 Gnai1 Akt2 Gnai3 Mapk3 Sphk2 Plcb3 Sphk1 S1pr1 S1pr2 S1pr5 Akt3 Mapk12 S1pr3 COMPREHENSIVE IL 17A SIGNALING%WIKIPATHWAYS_20260211%WP5242%MUS MUSCULUS Comprehensive IL 17A signaling Rbbp4 Tjp1 Akt1 Atox1 Igf1 Fn1 Sqstm1 Rela Col1a1 Ccn2 Bcl2 Mylk Ccl4 Ccl3 Mtor Cxcl15 Gng12 Ppp1r14b Smad2 Stat3 Pdgfa Stat1 Egfr Adh1 Smad6 Smad7 Prkacb Psmc6 Mki67 Pik3c3 Plaur Arpc3 Ptgs2 Arpc2 Snai2 Snai1 Arpc5 Jak2 Rac1 Pura C3 Zmpste24 C7 Mcm7 Sod2 Acta1 Acta2 Pcna Tnfsf13b Gap43 Mmp9 Mcm3 Ccl5 Mcm4 Mcm5 Mcm6 Mcm2 Cxcl1 Cxcl2 Pak3 Tgfb1 Anxa6 Cdc42 Orc1 Orc2 Casp3 Serbp1 Hyou1 Il1b Cacybp Uggt1 Becn1 Plch1 Cpne1 Nasp Trp53 Nucks1 Rras2 Hmgb1 Fbn1 Smad3 Hbb-bh1 Blmh Angpt1 Plau Mmp14 Npm1 Mmp3 Upf1 Samhd1 Pdgfb Map1lc3a Map1lc3b Pon3 Atrx Hspa1b Hbb-bs Rhoa Cxcl5 Il6 Hbbt1 Rab10 DYSREGULATED MIRNA TARGETING IN INSULIN PI3K AKT SIGNALING%WIKIPATHWAYS_20260211%WP3855%MUS MUSCULUS Dysregulated miRNA targeting in insulin PI3K AKT signaling Crkl Flot2 Prkx Exoc7 Col4a2 Pik3r1 Raf1 Sos1 Rheb Bcl2l11 Col1a2 Col3a1 Prkar2a Col1a1 Acaca Bcl2 Ccnd2 Eif4e2 Mapk3 Fasn Col5a3 Mtor Socs1 Bad Cdkn1b MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260211%WP2928%MUS MUSCULUS miR 222 in exercise induced cardiac growth Hmbox1 Hipk1 Hipk2 Cdkn1b FOCAL ADHESION PI3K AKT MTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP2841%MUS MUSCULUS Focal adhesion PI3K Akt mTOR signaling pathway Ngf Igf1 Fn1 Il6ra Ghr Il2ra Il2rb Il2 Gnb3 Vtn Lpar6 Lamb2 Lamb1 Ppp2r2d Col1a2 Lpar4 Col3a1 Col1a1 Lama5 Il2rg Il4ra Lamc1 Fgf7 Lamc2 Thbs1 Pten Thbs3 Mapk3 Eif4e2 Jak1 Csf3 Tnc Tnn Tnr Itgb6 Tnxb Col5a2 Col5a3 Hgf Col5a1 Pgf Spp1 Reln Lama4 Thbs2 Efna5 Thbs4 Pdgfc Fgf10 Pdgfd Chad Pdgfra Pdgfa Col4a4 Col4a2 Col4a6 Ibsp Pelo Flt1 Igf1r Pik3r4 Col11a1 Vegfd Col6a2 Lamc3 Acaca Il7r Fgf18 Ppp2ca Cab39 Irs1 Irs2 Hsp90aa1 Jak3 Foxo3 Vegfa Nos3 Kdr Jak2 Ifna1 Pik3r1 Raf1 Pik3cg Kras Map2k2 Il3ra Rps6kb2 Slc2a1 Ppp2r3a Ppp2r2c Ppp2r2b Ppp2r1b Ppp2r1a Ppp2r5d Gsk3b Ppp2r5c Ppp2r5b Ppp2r5a Prkaa1 Ppp2r5e Ddit4 Tsc2 Tsc1 Hsp90b1 Fgf1 Rheb Lipe Pik3c2g Hif1a F2r Vegfc Vegfb Angpt1 Ikbkb Mdm2 Ikbkg Cdkn1a Cdkn1b Itgam Rab10 Ifnb1 Akt1 Mapk1 Gys1 Gys2 Prkaa2 Rab11b Phlpp1 Phlpp2 Pik3ca Ppp2r3d Ppp2r3c Epo Nos2 Tcl1 Ulk1 Epor Insr Mtcp1 Pik3ip1 Tbc1d1 Sos1 Lpar5 Fgfr4 Gng14 Fgf16 Rptor Itgb2 Fgf17 Fgf14 Ifnab Gngt1 Prl Osmr Fgf12 Fgf13 Fgf11 Hif3a Fgf20 Fgf21 Fgf22 Akt2 Ifna4 Map2k1 Ifna5 Gnb1 Atf4 Ifna6 Rps6 Ifna7 Grb2 Ifna2 Ifna9 Foxa1 Strada Hras Rab8a Atf6b Comp Itga7 Csf3r Itga8 Fgf2 Fgf6 Itga5 Rab2a Eif4ebp1 Itga6 Fgf4 Eif4e1b Itga9 Fgf3 Fgf9 Itga3 Hsp90ab1 Itga4 Csf1 Gnb2 Mtor Creb3l3 Itga2 Gnb4 Creb3l4 Akt3 Creb3l1 Itga10 Creb3l2 Itga11 Gng11 Crtc2 Gng12 Csf1r Bad Gng13 Akt1s1 Egf Stk11 Cab39l Efna4 Creb1 Efna1 Itgax Efna2 Itgav Efna3 Pdpk1 Flt4 Eif4b Pfkfb4 Itgae Ptk2 Pfkfb3 Itgal Egfr Pfkfb1 Slc2a2 Lpar1 Slc2a3 Creb3 Lpar3 Itgad Angpt2 Itgb8 Pik3r5 Lpar2 Itgb7 Angpt4 Creb5 Itga2b Epha2 Itgb4 Ifna13 Itgb5 Ifna14 Ifna11 Itgb3 Mlst8 Gng3 Ifnar2 Gng2 Tcl1b4 Gng5 Tcl1b1 Gng4 Rab14 Tek Gng7 Gng8 Fgf8 Eif4e Kit Pik3c2a Kitlg Gh Ins2 Irs4 Fgfr3 Irs3 Fgfr1 Fgfr2 Prlr Lama1 Ppp2cb Lama2 Lama3 Fgf15 Met Lamb3 Epas1 Itgb1 Slc2a4 Nras Col11a2 Osm Gng10 Col2a1 Gngt2 Ngfr Ins1 Col4a1 Foxo1 Nos1 Elavl1 Ifnar1 Chrm1 Chrm2 Srebf1 Rps6kb1 Pik3cb Pik3cd Casp9 Pik3c2b Vwf Atf2 Pik3r2 Pdgfrb Ppargc1a Pdgfb Cdc37 MACROPHAGE MARKERS%WIKIPATHWAYS_20260211%WP2271%MUS MUSCULUS Macrophage markers Rac2 Cd74 Cd86 Cd52 Lyz2 Cd14 Cd163 Cd83 Cd68 F3 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260211%WP1250%MUS MUSCULUS Arachidonate epoxygenase epoxide hydrolase Cox5a Cox8a Ephx2 LIPIDS MEASURED IN LIVER METASTASIS FROM BREAST CANCER%WIKIPATHWAYS_20260211%WP4627%MUS MUSCULUS Lipids measured in liver metastasis from breast cancer Lrat FATTY ACID BETA OXIDATION STREAMLINED %WIKIPATHWAYS_20260211%WP3588%MUS MUSCULUS Fatty acid beta oxidation streamlined Cpt2 Acads Acadvl Fabp1 Cpt1a Acsl1 Acsl3 Acsl4 Slc25a20 Hadh Hadhb Decr1 Acat1 Echs1 Acsl5 Acsl6 Cpt1b Slc27a1 Fabp2 Fabp3 Fabp4 Fabp7 Slc27a5 Slc27a4 Slc27a3 Cd36 Slc27a2 Slc27a6 Hadha Acadl Eci1 Acadm PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260211%WP374%MUS MUSCULUS Prostaglandin synthesis and regulation Ptgs2 Ptgfr Ptgir Pla2g4a Anxa6 Prl Cyp11a1 Ednra Edn1 Ednrb Anxa8 S100a6 Scgb1a1 Hsd11b1 Hsd11b2 Anxa5 Anxa4 Tbxas1 Anxa3 Anxa2 Anxa1 S100a10 Ptger4 Hpgd Ptger2 Ptgds Ptger3 Ptgis Ptger1 Ptgs1 Ptgdr PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260211%WP63%MUS MUSCULUS Pentose phosphate pathway Rpia Rpe Taldo1 Pgls Tkt G6pdx Pgd STATIN PATHWAY%WIKIPATHWAYS_20260211%WP1%MUS MUSCULUS Statin pathway Apoa4 Apoc2 Pltp Apoe Cyp7a1 Lrp1 Dgat1 Lpl Apoc1 Lipc Soat1 Mttp Hmgcr Lcat Abca1 Ldlr Scarb1 Apoc3 Apoa1 NOVEL JUN DMP1 PATHWAY%WIKIPATHWAYS_20260211%WP3654%MUS MUSCULUS Novel Jun Dmp1 pathway Araf Arf1 Dmp1 Mapk1 Junb Braf E2f1 Raf1 Fos Kras Map2k2 Jun Ccnd1 Nras Rras Map2k1 Rb1 Mapk3 Trp53 Hras Cdk4 Myc Mdm2 Cdkn2a Ets1 Ets2 TGF BETA RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP258%MUS MUSCULUS TGF beta receptor signaling pathway Nfya Cav1 Fos Jun Ncoa1 Mapk14 Ccnd1 Crebbp Fkbp1a Atf3 Tgif1 Mapk8 Zeb2 Foxh1 Snw1 Skil Eng Lef1 Camk2a Myc Ctcf Sp1 Runx2 Tgfbr3 Kat2b Stk11 Smad2 Zfyve9 Tgfbr1 Eif3i Tgfbr2 Smad6 Smad7 Mef2c Prkar1b Prkcb Ube2d3 Map2k6 Ube2d1 Prkar2a Map2k3 Map3k7 Skp1 Btrc Ube2d2a Dab2 Axin1 Axin2 Tgfb2 Cul1 Ets1 Dvl1 Foxo3 Erbin Junb Pard3 Stambpl1 Kpnb1 Sumo1 Cdc27 Prkcd Cdc23 Dcp1a Hnf4a Rbx1 Pik3r1 Camk2g Eid2 Hgs Trp73 Ar Camk2d Nup153 Camk2b Gipc1 Arrb2 Sdc2 Anapc5 Snip1 Hspa8 Anapc4 Anapc1 Anapc2 Snx4 Trap1 Snx2 Vdr Snx1 Anapc7 Cited1 Tfdp2 Snx6 Cops5 Nup214 Rbl2 Sparc Fnta Esr1 Cdc16 Xpo1 Foxg1 Zeb1 Anapc10 Smurf2 Stk11ip Hoxa9 Nfyb Mef2a Nfyc Strap Fzr1 Ap2b1 Acvrl1 Fosb Ccne1 Cd44 Hdac1 Yap1 Tfdp1 Foxo1 Ccnb2 Ppp2r2a Foxo4 Rbl1 Cdc25a Ep300 Tgfb1 Rb1 Jund Trp53 Rock1 Atf2 Pik3r2 Smad3 Tgfb3 Cdk6 Smad4 Cdk4 Cdk2 Cdk1 Ctnnb1 Pias1 Pias2 Tab1 Daxx E2f4 Cdkn1a E2f5 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260211%WP567%MUS MUSCULUS Eukaryotic transcription initiation Ilk Ccnh Mnat1 Taf13 Taf12 Gtf2f2 Tbp Polr2c Gtf2a2 Polr2a Gtf2b Gtf2e1 Polr2b Taf9 Gtf2e2 Polr2g Polr2k Polr2h Gtf2h2 Gtf2h1 Polr2e Gtf2h4 Gtf2h3 Polr2i Ercc2 Polr2j Ercc3 Cdk7 Taf7 Polr1b Taf6 Polr1c Taf5 Polr3d Polr1a Polr3e Polr3b Polr1d Polr3h Ak6 Polr3k ID SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP512%MUS MUSCULUS ID signaling pathway Ngf Vegfa Kdr Nfkb1 Elk1 Igf1 Id3 Rela Cd40lg Rbl2 Lck Atf3 Hes1 Tgif1 Ccna2 Acvrl1 Ccne1 Elk3 Pax5 Pax8 Id2 Tcf12 Id4 Msc Tcf7l2 Egf Smad1 Smad5 Rbl1 Srebf1 Flt1 Igf1r Myod1 Elk4 Myog Myf6 Myf5 Rb1 Psmd4 Smad3 Bmpr2 Smad4 Bmp2 Cdk2 Ctnnb1 Pax2 Irs1 Id1 Bmp6 Tcf3 Tert OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260211%WP1248%MUS MUSCULUS Oxidative phosphorylation Ndufc1 Ndufc2 mt-Nd1 mt-Nd2 mt-Nd3 Ndufa10 Ndufs1 Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Atp5mc3 Atp5mc2 Ndufa3 Ndufa2 Ndufa5 Atp5pb Ndufa7 Atp5pd Ndufa6 Ndufa9 Ndufa8 Atp5pf Ndufb10 Atp5po Ndufb2 Ndufb6 Ndufb5 mt-Nd4l Ndufb7 Ndufb9 Ndufa11 Coxfa4l2 Atp5mc1 Atp6ap2 Atp6ap1 Gzmb Ndufb8 Coxfa4 ATP6 Atp5f1e Atp5f1d mt-Atp8 Atp5mf Atp5me Ndufv2 Dmac2l Atp5mg Ndufv1 Atp5f1b Ndufv3 Atp5f1a mt-Nd4 mt-Nd5 mt-Nd6 CHEMOKINE SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP2292%MUS MUSCULUS Chemokine signaling pathway Ccr2 Akt1 Pxn Mapk1 Prkx Ccl2 Nfkb1 Braf Cx3cr1 Sos2 Pik3ca Prkaca Gnb3 Sos1 Rela Shc2 Nfkbib Gng14 Ccr1 Chuk Gngt1 Ccr1l1 Akt2 Map2k1 Gnb1 Mapk3 Grb2 Grk5 Hras Shc3 Grk4 Ccl11 Grk6 Ccl4 Ccl3 Gnb2 Gnb4 Akt3 Gnb5 Gng11 Cxcl15 Gng12 Gng13 Stat3 Rac2 Stat1 Ptk2 Vav3 Rap1a Rap1b Prkacb Pik3r5 Vav2 Crk Prkcb Gng3 Bcar1 Gng2 Gng5 Pak1 Gng4 Gng7 Csk Gng8 Nfkbia Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Fgr Hck Plcb1 Crkl Jak3 Foxo3 Jak2 Pard3 Rac1 Itk Prkcd Vav1 Ccr10 Pik3r1 Raf1 Ncf1 Shc1 Arrb2 Arrb1 Pik3cg Kras Prkcz Lyn Xcr1 Ptk2b Nras Gnai2 Gnai1 Gnai3 Gng10 Ccr7 Gngt2 Plcb4 Stat2 Plcb3 Gsk3a Plcb2 Tiam1 Tiam2 Cxcr1 Rasgrp2 Shc4 Ppbp Grk1 Grk2 Elmo1 Stat5b Ccl21a Cxcl16 Gsk3b Cxcl13 Ccl20 Cxcl14 Ccl5 Ccl27a Xcl1 Ccl19 Ccl17 Dock2 Was Ccl9 Ccl8 Ccl12 Cxcl1 Cxcl9 Cxcl2 Ccl7 Ccl6 Ccl1 Pik3cb Pf4 Pik3cd Prex1 Cx3cl1 Cdc42 Ccl28 Ccl26 Ccl24 Ccl25 Ccl22 Wasl Rock2 Cxcr2 Cxcr3 Rock1 Pik3r2 Ikbkb Cxcl10 Ccr9 Cxcr4 Cxcr5 Ikbkg Ccr8 Cxcr6 Ccr6 Rhoa Ccr5 Cxcl5 Ccr4 Ccr3 T CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP480%MUS MUSCULUS T cell receptor signaling pathway Cd2 Dusp3 Akt1 Pxn Def6 Cd4 Mapk1 Trat1 Nfam1 Abi1 Braf Sos2 Wasf2 Grap2 Sh2b3 Khdrbs1 Zap70 Ptpn22 Dbnl Syk Rasa1 Fos Ptprc Cblb Sos1 Jun Prkcq Lck Mapk7 Crebbp Map2k1 Mapk3 Ncl Grb2 Vasp Arhgef7 Nck1 Plcg1 Txk Creb1 Rac2 Stat1 Ptk2 Vav3 Rap1a Stat5a Vav2 Crk Dtx1 Pak1 Muc1 Git2 Rapgef1 Sla2 Cd2ap Dlg1 Grap Shb Bcl10 Lat Crkl Jak3 Itk Gab2 Vav1 Pik3r1 Shc1 Card11 Ptpn6 Lime1 Cbl Lcp2 Ptpn11 Cd5 Fyn Sh3bp2 Lyn Nedd9 Ptk2b Map2k2 Cish Cebpb Hdac7 Rasgrp2 Stat5b Dock2 Sh2d3c Was Arhgdib Cdc42 Ppp3cb Sla Abl1 Prkd2 Sit1 Sh2d2a Lax1 Wipf1 Stk39 Map3k1 Fcrl5 Arhgef6 Unc119 Cabin1 Ripk2 Pag1 Itpr1 Tubb5 Nfatc2 Pik3r2 Fyb1 Homer3 Pstpip1 Cd8a Enah Ptprj Acp1 Ptprh Skap2 Src Ctnnb1 Skap1 Dnm2 Map4k1 Tuba4a Ptpn12 Evl Cd247 Cd3g Cd3e Ptpn3 Cd3d TCA CYCLE%WIKIPATHWAYS_20260211%WP434%MUS MUSCULUS TCA cycle Pdk1 Fh Mdh1 Idh3g Mdh2 Suclg2 Pdk3 Sucla2 Idh3a Pcx Pdhb Idh3b Ogdh Pdp1 Pdp2 Aco2 Dlat Sdhd Sdhc Sdhb Sdha Dld Pdha1 Pdha2 Pdhx Cs Suclg1 Pdk4 Idh2 Pdk2 Dlst IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP151%MUS MUSCULUS IL 5 signaling pathway Crkl Akt1 Mapk9 Foxo3 Mapk1 Jak2 Nfkb1 Rac1 Elk1 Vav1 Prkcd Icam1 Pik3r1 Pla2g4a Syk Raf1 Il2rb Hcls1 Shc1 Ptpn6 Cbl Il5 Ptpn11 Pik3cg Shc2 Kras Pim1 Sox4 Sdcbp Itgb2 Lyn Ptk2b Rap1gap Map2k2 Jun Mapk14 Il5ra Mapk3 Grb2 Jak1 Hras Gsk3a Stat3 Stat1 Stat5b Stat5a Gsk3b Ywhaz Prkcb Nfkbia Rapgef1 Bax Unc119 Ccnd3 Csf2rb Atf2 Pik3r2 Hck Rps6ka1 Alox5ap Btk Alox5 Ctnnb1 Socs1 Dnm2 Sh2b2 Itgam Cdkn1b GPCRS ODORANT%WIKIPATHWAYS_20260211%WP1397%MUS MUSCULUS GPCRs odorant Ptgdr2 Gpr137b Adgrf5 Gpr137c Slc52a2 Gpr161 Adgrf2 Gpr180 Gpr107 Gpr137 Gpr4 Gpr179 Gpr155 Tpra1 Gpr108 Gpr89 Gpr31 Wls Adgrg5 Hcar1 Adgrg6 Adgrg7 Gpr160 Adgrg3 Mrgpra6 Tas2r39 Or5p52 Tas2r38 Gpr61 Gpr63 Mrgpra1 Or10d3 Mrgpra4 Gpr176 Gpr173 Gpr171 Or8g17 Vmn2r1 Cmklr1 Cmklr2 Or4c3d Or8u9 Or5g25 Gpr75 Or5ap2 Adgra2 Gpr183 Tas1r2 Or5g9 Or10n1 Or10d1b Gpr101 Tas1r3 Or5p76 Or10h28 Gpr87 Or5p4 Gpr85 Tas2r135 Tas2r134 Gpr82 Or7d11 Tas2r136 Or5ar1 Or5b21 Gpr19 Or5p58 Or5p57 Or2c1 Mrgprb8 Gpr12 Mrgprb1 Tas2r143 Mrgprb2 Adgra3 Mrgprb3 Mrgprb4 Mrgprb5 Tas2r117 Tas2r116 Opn1sw Rho Or8a1b Gpr26 Gpr165 Or5h19 Gpr25 Gpr162 Or5h17 Or5h18 Gpr27 Gpr22 Gpr21 Or5j3 Ackr5 Gpr20 Tas2r113 Or3a10 Tas2r114 Tas2r129 Adgrd1 Gpr139 Oprl1 Gpr135 Or5p79 ADGRF3 Gpr33 Taar6 Gpr35 Taar9 Or7e178 Taar3 Tas2r120 Or5p80 Taar2 Taar5 Taar4 Or5g26 Tas2r124 Tas2r125 Gpr142 Gpr141 Opn1mw Mrgprx1 Taar7e Or5t7 Or5t9 Gpr153 Tas2r106 Tas2r107 Gpr152 Gpr150 Or2a7 Adgrf1 Tas2r109 Tas1r1 Or8b8 Or5t17 Or5t15 Gpr3 Or9s13 Or8b3 Or10p22 Gpr157 Gpr158 Gpr88 Gpr156 Gpr84 Or5m5 Gpr83 Lgr4 Lgr5 Lgr6 Tas2r102 Or4b13 Mrgpre Tas2r104 Mrgprf Mrgprg Or6b9 Or2b6 Or1j1 Or7a40 Or2y1b Gpr34 V1ra8 Gpr37 Vmn1r53 Vmn1r54 Vmn1r51 Vmn1r52 Gpr146 Or1e16 Adgrf4 Vmn1r48 Vmn1r46 Vmn1r47 Gpr37l1 Vmn1r45 Vmn1r42 Vmn1r43 Mrgprh Or1m1 Brs3 TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260211%WP1253%MUS MUSCULUS Type II interferon signaling IFNG Ifnb1 Jak2 Tap1 Stat1 Eif2ak2 Prkcd Irf4 Icam1 Nos2 Ptpn11 Cxcl9 Ifng Hist2h4 Gbp2b Ifngr2 Ifngr1 Reg1 Ciita Irf1 Irf2 Irf8 Isg15 Psmb9 Irf9 Ifit2 Il1b Spi1 Jak1 Stat2 Cxcl10 Socs1 Cybb Socs3 TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP246%MUS MUSCULUS TNF alpha NF kB signaling pathway Traf2 Akt1 Fbl Nfkb1 Cav1 Pebp1 Ywhah Prkaca Tnfrsf1b Tnfrsf1a Rela Papola Nfkbib Elp1 Casp2 Rel Chuk Crebbp Map3k14 Akt2 Ikbke Polr1b Polr1c Polr1a Polr1d Polr1e Ddx3x Hsp90ab1 Gab1 Capn3 Ywhae Ywhab Stat1 Ptk2 Psmd12 Psmd13 Ywhaz Psmb5 Birc3 Birc2 Map2k5 Psmc2 Psmc1 Nfkbia Psmc3 Relb Traf3 Bag4 Psmd7 Skp1 Ppp2ca Traf1 Psmd6 Nfkbie Nfkb2 Alpl Psmd3 Btrc Gtf2i Cul1 Csnk2a2 Csnk2a1 Hsp90aa1 Mark2 Csnk2b Nr2c2 Rack1 Sumo1 Ptpn11 Akap8 Rps11 Rps13 Prkcz Tab2 Polr2h Rnf25 Nkiras1 Rpl4 Nkiras2 Nlrp4e Rpl6 Tbk1 Unc5cl Dpf2 Azi2 Ppp1r13l Rnf216 Usp2 Polr1g Mcm7 Fbxw11 Casp8ap2 Txlna Tank Ywhag Tradd Actl6a Smarce1 Hdac2 Rps6ka5 Tifa Cdc34 Traip Rpl30 Nfkbiz Hdac1 Glg1 Ripk3 Cradd G3bp2 Dcaf7 Hdac6 Cops3 Kpna6 Mcc Kpna3 Kpna2 Dap Tnfrsf11a Bcl3 Tab3 Ccar2 Traf4 Rpl8 Map3k3 Pfdn2 Gsk3b Traf5 Fadd Faf1 Tnfrsf8 Smarcb1 Rasal2 Mcm5 Peg3 Bcl7a Cyld Fkbp5 Smarca4 Tnip2 Rps6kb1 Pdcd2 Nsmaf Zfand5 Ripk1 Cflar Map3k2 Commd1 Iqgap2 Trpc4ap Fancd2 Casp8 Psmd1 Casp7 Pml Ktn1 Usp11 Smarcc2 Casp3 Smarcc1 Tnfaip3 Map3k8 Lrpprc Mtif2 Map3k1 Eif4a3 Pkn1 Ripk2 Pias3 Ikbkb Ube2i Hspb1 Tnip1 Src Traf6 Ikbkg Flna Tab1 Tnf Cdc37 Kcnq1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260211%WP273%MUS MUSCULUS Ovarian infertility Gja4 Lhcgr Prlr Tbp Cyp19a1 Vdr Esr2 Smpd1 Ncor1 Zp3 Inha Zp2 Pgr Syne2 Ccnd2 Bmpr1b Mlh1 Nr5a1 Gdf9 Dmc1 Msh5 Nrip1 Smad3 Cdk4 Fshr Egr1 Ptger2 Cebpb Atm Dazl Cdkn1b ESC PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260211%WP339%MUS MUSCULUS ESC pluripotency pathways Akt1 Mapk1 Braf Elk1 Fos Sos1 Fgfr4 Il6st Fgf16 Fgf17 Fgf14 Jun Fgf12 Fgf13 Fgf11 Mapk7 Fgf20 Mapk6 Fgf21 Mapk4 Fgf22 Fgf7 Akt2 Map2k1 Pten Grb2 Jak1 Hras Nog Fgf2 Fgf6 Fgf4 Fgf3 Fgf9 Mtor Myc Akt3 Wnt1 Lif Egf Smad1 Gab1 Fgf10 Stat3 Araf Smad9 Pdgfra Pdgfa Egfr Smad5 Smad6 Smad7 Map2k6 Map2k5 Mapk12 Map2k3 Wnt11 Wnt5a Wnt6 Wnt7b Fgf8 Wnt5b Fgf18 Wnt9b Wnt10a Wnt2b Wnt16 Wnt2 Wnt4 Axin1 Wnt3 Fzd4 Fzd6 Fzd8 Actr2 Bmpr1a Wnt3a Dvl1 Dvl2 Dvl3 Fzd3 Fgfr3 Lifr Fgfr1 Lrp6 Fgfr2 Lrp5 Raf1 Fgf15 Wnt7a Ptpn11 Apc Fzd1 Fzd2 Fzd5 Fzd7 Map2k2 Fzd9 Fgf23 Acvr1 Wnt10b Hnf1a Selenop Gsk3b Fgf1 Pik3cd Bmpr1b Pik3r2 Fgf5 Eras Smad4 Bmpr2 Pdgfrb Ctnnb1 Pdgfb Mdm2 Bmp4 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP88%MUS MUSCULUS Toll like receptor signaling Ticam2 Irak4 Ralbp1 Nfkb1 Abi1 Eif2ak2 Ticam1 Nr2c2 Fadd Irak2 Irak1 Tlr2 Map2k6 Myd88 Irak3 Irf3 Tab2 Chuk Casp8 Tlr4 Tirap Mapk14 Tlr3 Traf3 Casp3 Ikbke Nfkb2 Tbk1 Mal Mxd3 Ikbkb Traf6 Ikbkg HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260211%WP3673%MUS MUSCULUS Hfe effect on hepcidin production Tmprss6 Hjv Hfe Hamp Smad7 Id1 Bmp6 DISTAL CONVOLUTED TUBULE 1 DCT1 CELL%WIKIPATHWAYS_20260211%WP4183%MUS MUSCULUS Distal convoluted tubule 1 DCT1 cell Wnk1 Cab39 Stk39 Slc12a3 Wnk4 Kcnj16 Clcnkb CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260211%WP222%MUS MUSCULUS Cytokines and inflammatory response Ifnb1 Cd4 Pdgfa Cxcl3 Ifna1 Il2 Il4 Il5 Cxcl1 Ifng Il1a Tgfb1 Il13 Il1b Il3 Csf2 Csf3 Csf1 Il10 Il12b Il11 H2-Eb1 Il15 Tnf Il12a Il6 Il7 DRAVET SYNDROME SCN1A A1783V POINT MUTATION MODEL%WIKIPATHWAYS_20260211%WP5298%MUS MUSCULUS Dravet syndrome Scn1a A1783V point mutation model Rictor Scn1a Scn1b Akt1 Gabra4 Grm3 Kdr Ppp1r1b Nfkb1 Gabra3 Stxbp3 Gabra2 Pcdh19 Slc6a1 Slc16a7 Pik3ca Slc16a1 Slc12a5 Stx8 Kcna2 Gria4 Gria3 Gls Scn2b Gria1 Chd2 Maob Stx16 Ldhb Ctps2 Cacna2d3 Kcnj9 Scn3a Scn3b Slc1a3 Slc38a3 Slc17a7 Fgf13 Kcnj3 Cacnb4 Scn4b Mapkap1 Kcnj10 Gabrb1 Epb41l3 Gabrb3 Prr5l Gabbr2 Gabbr1 Slc1a2 Slc2a1 Rasgrf1 Mtor Camk2a Ldha Cacna1a Cacna1b Grin1 Gad1 Mapk11 Slc2a3 Grin2a Gabra1 Mlst8 Stxbp1 Glul Cacnb3 Cacnb1 Gad2 Maoa Gfap Tnf Prr5 NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP29%MUS MUSCULUS Notch signaling pathway Dvl3 Ctbp1 Mfng Rbpj Numb Psen1 Psen2 Maml3 Numbl Ncstn Aph1a Aph1b Ctbp2 Dtx1 Maml1 Ncor2 Jag2 Jag1 Notch4 Cirsr Notch1 Notch2 Notch3 Lfng Crebbp Dll1 Dll3 Dtx2 Dll4 Dtx3 Dtx4 Hes1 Dtx3l Hes5 Kat2a Rfng Ptcra Snw1 Hdac2 Adam17 Hdac1 Tnf Kat2b Rbpjl Dvl1 Dvl2 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4351%MUS MUSCULUS Omega 9 fatty acid synthesis Acsl1 Acsl3 Acsl4 Fads2 Fads1 Acot1 Elovl2 Acot2 Elovl3 Elovl5 Fasn Elovl1 Scd2 Elovl6 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260211%WP33%MUS MUSCULUS Fatty acid omega oxidation Adh7 Cyp1a2 Adh4 Adh1 Cyp2e1 Aldh2 Cyp1a1 Aldh1a1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP300%MUS MUSCULUS Histone modifications Hdac2 Ehmt2 Ehmt1 Hdac1 Hat1 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260211%WP578%MUS MUSCULUS Leptin insulin signaling overlap Stat3 Pdpk1 Akt1 Irs4 Jak2 Socs2 Irs3 Lep Insr Lepr Dgkz Pik3cg Socs1 Ins1 Socs3 Irs1 Irs2 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260211%WP412%MUS MUSCULUS Oxidative stress response Junb Nfkb1 Cyp1a1 Gpx1 Gstt2 Gpx3 Fos Gsr Txnrd1 Txnrd2 Cat Mapk14 Ugt1a1 Mapk10 Mt1 Maoa Txn2 Nqo1 Nfix Hmox1 Sod3 Sod2 Gclc Sod1 Cyba Gabpb1 Sp1 Mgst1 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260211%WP157%MUS MUSCULUS Glycolysis and gluconeogenesis Pkm Pklr Pdhb Dlat Ldhb Gck Slc2a4 Pdhx Slc2a1 Gpi Eno3 Eno2 Mpc1 Mpc2 Pgam2 Ldha Pgam1 Slc2a5 Gapdh Ldhc Fbp1 Fbp2 Ldhal6b Gapdhs Aldoc Aldoa Pfkl EG433182 Pgk1 Pgk2 Pfkm Slc2a2 Pfkp Slc2a3 Pck1 G6pc1 Hk2 Hk1 Mdh1 Hk3 Mdh2 Aldob Pcx Tpi1 Dld Pdha1 Pdha2 Got1 Got2 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260211%WP431%MUS MUSCULUS Nuclear receptors in lipid metabolism and toxicity Cyp24a1 Cyp26a1 Nr1i3 Nr1i2 Abcb1a Abcd2 Abcd3 Abcb4 Cyp2b10 Cyp7a1 Rara Nr1h4 Rarb Abcg1 Abcc3 Rarg Abcg5 Abcb11 Vdr Cyp27b1 Nr1h3 Cyp4b1 Ppard Cyp8b1 Abcc2 Ppara Pparg Cyp1a2 Cyp2e1 Abca1 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260211%WP3625%MUS MUSCULUS Tyrobp causal network in microglia Cd4 Sh2b3 Ncf2 Hcls1 Tnfrsf1b Rgs1 Itgb2 C3 C1qc Slc1a5 Gal3st4 Spp1 Runx3 Creb3l2 Itgax Tgfbr1 Stat5a Cxcl16 Gpx1 Plek Rbm47 Adap2 Il18 Sft2d2 Cytl1 Tmem106a Lyl1 Dpyd Il13ra1 Cd84 Kcne3 Abcc4 Bin2 Npc2 Elf4 Lhfpl2 Cd37 Samsn1 Ppp1r18 Il10ra Zfp36l2 Apbb1ip Fkbp15 Hlx Rnase6 Tcirg1 Loxl3 Gapt Slc7a7 Rps6ka1 Pycard Capg Igsf6 Nrros Maf Tyrobp Nckap1l Itgam PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260211%WP4835%MUS MUSCULUS Peroxiredoxin 2 induced ovarian failure Casp3 Prdx2 Star Cycs Cyp11a1 Hsd3b3 Bax NA K ATPASE SRC SIGNALING%WIKIPATHWAYS_20260211%WP5051%MUS MUSCULUS Na K ATPase Src signaling Crkl Akt1 Mapk9 Mapk1 Kdr Ilk Rac1 Braf Cav1 Elk1 Vav1 Pik3r1 Pik3ca Raf1 Rac3 Shc1 Met Sos1 Pik3cg Fyn Map2k2 Jun Ccnd1 Mapk7 Pak6 Mapk6 Mapk4 Akt2 Map2k1 Pten Bcl2 Grb2 Hras Mapk8 Shc3 Erbb2 Mtor Akt3 Pak4 Bad Cav3 Cav2 Blk Srms Txk Araf Rac2 Pdgfra Ptk2 Selenop Egfr Tesk2 Rap1a Tnk1 Rap1b Apaf1 Gsk3b Ptk6 Pik3r5 Crk Flt1 Birc3 Igf1r Birc2 Pik3r4 Dock1 Map2k6 Bcar1 Pak5 Map2k5 Pak1 Pak3 Pik3cb Styk1 Pak2 Pik3cd Mapk12 Map2k3 Rapgef1 Atp1b1 Tnk2 Casp9 Casp3 Cycs Cyct Ccnd2 Ccnd3 Pik3r2 Fgr Hck Pdgfrb Xiap Src Ctnnb1 Atp1a1 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260211%WP1272%MUS MUSCULUS Selenium micronutrient network mt-Co1 Selenop Xdh Fads2 Gpx2 Gpx1 Fads1 Gpx4 Gpx3 Gpx6 Tbxas1 Gsr Mtr Kmo Alox5 Cat mt-Co2 Ptges Pnpo Ptgds Mthfr Ptgis Selenok NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP1256%MUS MUSCULUS Nod like receptor NLR signaling pathway Ikbkb Erbin Rela Ephb2 Ikbkg Chuk Cd40 Mapk8 Map3k7 PPAR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP2316%MUS MUSCULUS PPAR signaling pathway Cpt2 Acaa1b Cyp4a12a Apoa2 Pltp Apoa5 Cyp4a12b Cyp4a14 Cpt1a Acsl1 Fabp5 Ilk Scp2 Cyp4a10 Fabp6 Acsl3 Acsbg1 Acsl4 Acsbg2 Acox1 Mmp1a Mmp1b Acox2 Me1 Acox3 Cpt1c Acaa1a Cyp7a1 Pck2 Plin1 Ucp1 Adipoq Nr1h3 Ppard Ppara Pparg Fabp4 Rxrb Rxra Sorbs1 Rxrg Pdpk1 Fabp1 Pck1 Fads2 Gk Lpl Hmgcs2 Gk2 Acsl5 Acsl6 Cpt1b Slc27a1 Cyp8b1 Ubc Fabp2 Fabp3 Fabp7 Slc27a5 Slc27a4 Cyp27a1 Cd36 Slc27a2 Slc27a6 Scd4 Scd3 Scd2 Scd1 Aqp7 Dbi Angptl4 Cyp4a30b Cyp4a32 Acadl Olr1 Cyp4a31 Ehhadh Apoc3 Cyp4a29 Apoa1 Acadm MISMATCH REPAIR%WIKIPATHWAYS_20260211%WP1257%MUS MUSCULUS Mismatch repair Rpa1 Pcna Pold1 Mlh1 Msh6 Lig1 Msh2 Rfc1 Exo1 FAS PATHWAY AND STRESS INDUCTION OF HSP REGULATION%WIKIPATHWAYS_20260211%WP571%MUS MUSCULUS FAS pathway and stress induction of HSP regulation Apaf1 Fadd Faf1 Lmna Parp1 Lmnb1 Arhgdib Ptpn13 Lmnb2 Mapkapk3 Sptan1 Pak1 Dffa Casp6 Dffb Cflar Il1a Pak2 Mapkapk2 Prkdc Casp8 Map2k4 Casp7 Jun Map3k7 Casp9 Casp3 Fas Rb1 Map3k1 Bcl2 Ripk2 Mapk8 Fasl Hspb1 Tnf Daxx GPCRS NON ODORANT %WIKIPATHWAYS_20260211%WP1396%MUS MUSCULUS GPCRs non odorant Vipr2 Ghrhr Adcyap1r1 Gipr Adgrg2 Gcgr Adgre1 Adgrl2 Sctr Adgrl3 Adgrl4 Adgrl1 Adora2b Glp2r Adora2a Calcrl Lpar6 Glp1r Crhr2 P2ry6 P2ry4 P2ry2 P2ry1 Lpar4 Gabbr2 Cysltr2 Pth1r Fzd4 Fzd6 Fzd8 Adra2a Adra2c Adra2b Htr4 Hrh1 Htr6 Htr7 Hrh2 Htr2b Drd3 Drd4 Htr1f Htr1b Htr5b Htr5a F2r Cckar Ednrb Cxcr2 Npy1r Cxcr3 Gnrhr Npy5r Ntsr2 Ntsr1 Trhr Mc2r Oprd1 Fshr C3ar1 Ccr9 Cxcr4 Cxcr5 Ccr8 Cxcr6 Ccr6 Tbxa2r Ccr4 Ptgdr Ccr3 Ccr2 Galr2 Ptgfr Cckbr Galr1 Grm3 Npy4r Cx3cr1 Lhcgr Avpr2 Sstr4 Sstr3 Sstr2 Ptgir Mc1r Sstr1 Avpr1b Mc5r Tacr1 Avpr1a Tacr2 C5ar1 Fpr1 Lpar5 Nmbr Bdkrb2 Bdkrb1 Tshr Agtr1a Agtr1b Ccr1 Oxtr Npy2r Npy6r Grpr Mc3r Gper1 Ccr1l1 Rxfp2 Rxfp1 Lpar1 Lpar3 Lpar2 Oprk1 Htr2a Htr2c Crhr1 Ghsr Prokr1 Adgrg1 Ackr3 Ednra Rrh Adrb2 Adrb1 Sstr5 Smo Oprm1 Tacr3 Calcr Casr Fzd3 Ccr10 Vipr1 Drd1 Celsr3 Drd2 Celsr1 Drd5 Celsr2 Gpr174 Fzd1 Rxfp3 Xcr1 Rxfp4 Fzd2 Tas2r16 Fzd5 Tas2r13 Fzd7 Tas2r137 Adgrb1 Fzd9 Adgrb2 Adgrb3 Gpr18 Gpr15 Gpr17 Adora1 Tas2r140 Adora3 Npbwr1 Ltb4r2 Gpbar1 Nmur2 Nmur1 Tmigd3 Tas2r4 Grm1 Tas2r7 Gabbr1 Mchr1 Rgr Ccr7 Taar1 Gprc5b Gprc5a Gpr132 Kiss1r Gprc5d Npffr2 Gprc6a Gpr6 Mtnr1b Npsr1 Mtnr1a P2ry10 P2ry13 Cnr2 Ptger4 P2ry12 Ptger2 P2ry14 Ptafr Mas1 Ptger3 Gpr50 Htr1d Ptger1 F2rl1 Tas2r40 S1pr3 Tas2r41 Ltb4r1 Htr1a S1pr4 F2rl2 F2rl3 Prokr2 Cxcr1 Gpr143 Hcar2 Gpr65 Adra1b Adgre5 Adra1a C5ar2 Adrb3 Ffar3 Gpr68 Adra1d Ffar4 Aplnr Ffar1 Ffar2 Chrm1 Chrm3 Hrh4 Chrm2 Hrh3 Opn4 Chrm5 Opn3 Mc4r Chrm4 Ccrl2 Oxgr1 Opn5 Sucnr1 Gpr119 S1pr1 Pth2r Tas2r119 Prlhr S1pr2 Grm2 S1pr5 Grm5 Grm4 Grm7 Grm6 Grm8 Tas2r110 Qrfpr Tas2r123 Adgre4 Hcrtr2 Hcrtr1 Cysltr1 Tas2r105 Ackr2 Uts2r Mrgprd Ackr1 Tas2r103 Cnr1 Agtr2 FATTY ACID OXIDATION%WIKIPATHWAYS_20260211%WP2318%MUS MUSCULUS Fatty acid oxidation Cpt2 Acads Acadvl Cpt1a Slc25a29 Echs1 Hadh Acaa2 Mttp Acadm MECHANISMS ASSOCIATED WITH PLURIPOTENCY%WIKIPATHWAYS_20260211%WP1763%MUS MUSCULUS Mechanisms associated with pluripotency Ddb1 Rbbp7 Ptprs Hells Suz12 Pbrm1 Xpo4 Sall1 Med12 Zfx Mtf2 Acvr1c Lyar H3-3b Stk40 Pou2f1 Rybp Leo1 Mbd3 Dpysl2 Cdx2 Acvr1b Mbd2 Satb2 Satb1 Elp4 Etv5 Wwp2 Il6st Zscan10 Pim1 Grsf1 Nr2c1 Rif1 Zfp42 Mpl Pou5f1 Ipo7 Nanog Mycn Ncoa1 Ipo9 Dgka Pim3 Tle4 Tle2 Fbxo15 Kdm1a Usp7 Hira Perp Pten Sall4 Sall3 Mapk3 Tcf7 Jarid2 Nppb Tfap2c Jak1 Niban1 Nedd4l Tfe3 Tfcp2l1 Jade1 Plet1 Zfp57 Nacc1 Kmt2d Sox2 P4ha1 Ogt Cdc73 Lef1 Spp1 Otx2 Kdm4c Zic2 Zic3 Gadd45gip1 Cdk2ap1 Lif Utf1 Smad1 Ewsr1 Eed Smad2 Mybl2 Npr1 Kdm5c Stat3 Kdm6a Rcn2 Chd4 Igfbp3 Smarca2 Smarca5 Dppa4 Tgfbr1 Trim28 Trim24 Epop Smad7 Rnf2 Zfp219 Mta1 Smarcad1 Arid3b Ercc5 Trim33 Kdm3a Tbx3 Ssrp1 Dkk1 Yy1 Wnt5a Relb Shh Hand2 Nme2 Irs1 Pin1 Ctbp1 Sumo1 Icam1 Lrp5 Nkd1 Raf1 Esrrb Nr2f6 Ptpn11 Apc Nr0b1 Nr2f2 Nr2f1 Dnmt3a Socs2 Nr5a2 Cers2 Cd44 Dnmt3b Dnmt1 Hdac2 Hdac4 Cdh1 Hdac1 Cdkn2a Kpna2 Ppp2r1a Sgk1 Gsk3b Myod1 Smarca4 Ep300 Gadd45a Tgfb1 Pml Smarcc1 Hif1a Gdf9 Trp53 Fgf5 Eras Smad3 Smad4 Bmpr2 Gata6 Cdk2 Mdm2 Atrx Cdkn1a Dazl Tert Rbbp4 Akt1 Mapk1 Nfkb1 Tcl1 Prkaca Fos Insr Inhbb Sos1 Rela Rel Ccnd1 Prkcg Crebbp Map2k1 Grb2 Ncl Sin3a Hras Fgf4 Cad Mtor Rest Myc Ctcf Sp1 Sp3 Gab1 Creb1 Tet1 Tpo Mef2c Ezh2 Mitf Twist1 Hck Foxd3 Axin1 Smo Tfap2a Wnt3a Id1 Dvl1 Rbpj Kpnb1 Fgfr1 Lifr Parp1 Ctbp2 Dffa Fzd1 Itgb1 Notch1 Rbl2 Mef2d Rras Gbx2 Dhx9 Hnrnpu Acvr1 Nodal T Ins1 T2 Tcf7l1 Klf4 Klf2 Klf5 Psen1 Rtn4r Tfeb Pik3cd Casp3 Ehmt2 Znf281 Ehmt1 Rcor2 Rock2 Thap11 Cer1 Cabin1 Sf1 Rock1 Skic8 Atf2 Uhrf1 Nobox Hcfc1 Zmym2 Znf143 Pias4 Kdm6b Kat5 Lefty1 Bcam Ube2i Ocln Dnmt3l Phc1 Ctnnb1 Ctr9 Pias2 Paf1 Tle5 Gatad2a Brca1 Mta2 Gatad2b Cubn Ezh1 Bmp4 Terf2 Ep400 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260211%WP189%MUS MUSCULUS GPCRs class A rhodopsin like Avp Adora2b Adora2a P2ry6 P2ry4 P2ry2 P2ry1 Gpr63 Or8g17 Cmklr1 Or10n1 Gpr87 Gpr19 Or5p57 Or2c1 Gpr12 Or13j1 Or8b12c Or10d1 Or8b12i Or8c15 Opn1sw Or8c16 Or8a1b Or2d3b Or8d2b Or8d1b Tcp10b Or11h4 Fpr2 Gpr27 Or8b12 Or8b40 Or8b39 Or8b101 Or6e1 Or10j5 Gpr45 Or2ag2 Or2ag1 Or8g23 Or8g24 Or8g26 Or8g27 Gpr33 Or8c8 Or8g28 Gpr35 Or8g18 Or10d4b Or10d4c Or10d1c Or8g2b Or2ag19 Or8g32 Or8g34 Or8g35 Or8g36 Or8g37 Or6b6 Opn1mw Or2ag20 Or13c7d Or13c7 Or13c7b Or8g30 Or2d2 Or2d4 Or2d3 Or8g53 Or8g55 Or13e8 Or8d23 Or8a1 Or8b8 Fpr-rs4 Fpr-rs3 Gpr3 Or8b4 Or2d36 Or10a4 Or10a5 Or10a2 Adra2a Adra2c Adra2b Htr4 Hrh1 Htr6 Htr7 Hrh2 Htr2b Drd3 Drd4 Htr1f Htr1b Htr5b Htr5a Gpr37 F2r Cckar Ednrb Cxcr2 Npy1r Cxcr3 Npy5r Ntsr2 Ntsr1 Trhr Brs3 Fpr-s1 Mc2r Oprd1 Fshr C3ar1 Ccr9 Cxcr4 Cxcr5 Ccr8 Ccr6 Ccr5 Tbxa2r Ccr4 Ptgdr Ccr3 Ccr2 Galr2 Galr3 Ptgfr Cckbr Galr1 Ptgdr2 Npy4r Cx3cr1 Lhcgr Avpr2 Sstr4 Sstr3 Sstr2 Ptgir Mc1r Sstr1 Avpr1b Mc5r Avpr1a C5ar1 Fpr1 Nmbr Bdkrb2 Bdkrb1 Tshr Agtr1a Agtr1b Ccr1 Oxtr Npy2r Npy6r Grpr Mc3r Gper1 Ccr1l1 Oxt Oprk1 Htr2a Htr2c Rho Or8g20 Ackr3 Rrh Oprl1 Adrb2 Adrb1 Or8g19 Sstr5 Oprm1 Or6a2 Gpr83 Or6b9 Adora3 Nmur1 Tmigd3 Gabbr1 Rgr Or7a40 Or2ag2b Mtnr1a P2ry13 Cnr2 Ptger4 P2ry12 Ptger2 P2ry14 Ptafr Mas1 Ptger3 Gpr50 Htr1d Ptger1 F2rl1 Gpr34 Ltb4r1 Htr1a F2rl2 F2rl3 Hcar2 Gpr65 Adra1b Adra1a Adrb3 Adra1d Aplnr Chrm1 Chrm3 Chrm2 Opn4 Opn3 Mc4r Chrm4 Ccrl2 Sucnr1 Trhr2 Gpr37l1 Cysltr1 Ackr2 Cnr1 Agtr2 MIRNAS AND TFS IN IPS CELL GENERATION%WIKIPATHWAYS_20260211%WP2375%MUS MUSCULUS miRNAs and TFs in iPS Cell Generation Phf5a Sox2 Ddx39b Sf3a3 Snrpa Pou5f1 Prpf4 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260211%WP1252%MUS MUSCULUS Amino acid conjugation of benzoic acid Acss2 Glyat RETINOL METABOLISM%WIKIPATHWAYS_20260211%WP1259%MUS MUSCULUS Retinol metabolism Adh4 Adh1 Aldh1a2 Cyp26a1 Dhrs3 Rdh8 Rdh12 Rara Aldh1a3 Rarb Rdh10 Bco2 Rarg Abcg5 Bco1 Lpl Npc1l1 Rbp7 Abcg8 Rpe65 Rbp4 Rbp2 Retsat Rbp1 Rdh5 Crabp1 Lrat Crabp2 Rlbp1 Sult1a1 Rxrb Rxra Cd36 Rxrg Cyp2e1 Aldh1a1 Sult2b1 Cyp26b1 Scarb1 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260211%WP327%MUS MUSCULUS GPCRs class C metabotropic glutamate pheromone Gprc5c Grm3 Gabbr2 Grm1 Gabbr1 Gprc5b Gprc5a Gprc5d Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 Casr CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260211%WP4346%MUS MUSCULUS Cholesterol metabolism with Bloch and Kandutsch Russell pathways Acsl1 Acsl3 Acsl4 Cyp7a1 Dhcr24 Nr1h3 Nr1h2 Cyp51a1 Ch25h Ggps1 Lbr Acat2 Soat2 Tm7sf2 Mylip Idi2 Ebp Acot1 Acot2 Fads2 Srebf1 Abcg1 Hmgcs2 Fdps Acat1 Nsdhl Mvk Dhcr7 Srebf2 Fdft1 Hmgcr Lss Sqle Pmvk Sc5d Mvd Msmo1 Cyp27a1 Hmgcs1 Hsd17b7 Cyp46a1 Fads1 Elovl2 Elovl3 Elovl4 Elovl5 Fasn Scd2 Scd1 Idi1 Soat1 Abca1 APOPTOSIS%WIKIPATHWAYS_20260211%WP1254%MUS MUSCULUS Apoptosis Traf2 Hells Akt1 Nfkb1 Igf1 Pik3r1 Trp73 Tnfrsf1b Tnfrsf1a Rela Irf3 Nfkbib Dffa Casp6 Dffb Casp2 Chuk Map2k4 Jun Irf2 Casp1 Bcl2 Hrk Prf1 Trp63 Bok Birc5 Bcl2l2 Tnfsf10 Bnip3l Scaf11 Tradd Pmaip1 Bcl2l1 Lta Irf7 Irf5 Myc Gzmc Tnfrsf21 Casp4 Tnfrsf25 Bad Diablo Cradd Apaf1 Irf4 Fadd Birc3 Igf1r Birc2 Cflar Ripk1 Bcl2l11 Bid Mcl1 Casp8 Nfkbia Irf1 Casp7 Bax Casp9 Traf3 Casp3 Bak1 Traf1 Nfkbie Fas Map3k1 Trp53 Mapk10 Tnfrsf10b Ikbkb Fasl Xiap Mdm2 Ikbkg Irf6 Igf2 Tnf CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260211%WP163%MUS MUSCULUS Cytoplasmic ribosomal proteins Rpsa Rps6ka3 Rpl19 Rpl11 Rpl12 Rps14 Rps11 Rps13 Rpl4 Rps7 Rpl6 Rps6 Rps6kb2 Rpl30 Rps15 Rps16 Rpl3 Rps17 Rps18 Rps15a Rps19 Rpl35 Rps27 Rpl36 Rps28 Rps27a Rps10 Rps29 Rpl37 Rps12 Rps6ka2 Rps20 Rpl38 Rpl31 Rpl8 Rpl34 Rpl39 Rpl36a Rpl9 Rps3a1 Rps23 Rpl7 Rps8 Rps5 Rpl32 Rpl37a Rps24 Rplp2 Rpl24 Rpl27 Rpl28 Rpl29 Rpl21 Rpl26 Rplp0 Rplp1 Rpl13a Rpl18a Rpl22 Rpl13 Rps4x Rpl15 Rpl17 Rpl18 Rpl10 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps26 Rpl27a Rps21 Rpl41 Rpl35a Fau Rpl23a Rps6ka1 MAPK CASCADE%WIKIPATHWAYS_20260211%WP251%MUS MUSCULUS Mapk cascade Araf Mapk1 Braf Elk1 Map3k3 Raf1 Map2k6 Kras Map3k2 Mapk12 Map2k4 Map2k3 Map2k2 Jun Mapk14 Nras Map3k12 Rras Map2k1 Map3k1 Mapk3 Rasa3 Map2 Sipa1 Hras Mapk10 Plcb3 Mbp MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260211%WP1263%MUS MUSCULUS Mitochondrial gene expression Gabpa Nrf1 Tfb1m Ppp3ca Tfb2m Esrra Mterf1a Hcfc1 Gabpb2 Mterf3 Tfam Pprc1 Polrmt Ppargc1a Ppargc1b Camk4 Myef2 Sp1 Creb1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260211%WP523%MUS MUSCULUS Regulation of actin cytoskeleton Baiap2 Diaph3 Pxn Apc2 Rassf7 Mapk1 Fgd1 Tmsb4x Braf Sos2 Arhgap35 Wasf2 Gsn Wasf1 Pip5kl1 Abi2 Fn1 Pik3ca Rac3 Sos1 Fgfr4 Bdkrb2 Bdkrb1 Fgf16 Fgf17 Cd14 Fgf14 Mos Fgf12 Fgf13 Actb Fgf11 Fgf20 Pak6 Mapk6 Fgf21 Mapk4 Fgf22 Fgf7 Map2k1 Mapk3 Mylk Vcl Arhgef7 Ppp1r12a Fgf2 Fgf6 Fgf4 Fgf3 Fgf9 Itga1 Pak4 Gng12 Egf Fgf10 Pdgfra Rac2 Pdgfa Ptk2 Egfr Pik3r5 Crk Actn1 Pik3r4 Dock1 Bcar1 Pak5 Pak1 Csk Pak2 Pip5k1c Fgf8 Fgf18 Pik3c3 Pik3c2a Pip4k2b Pip4k2c Ins2 Nckap1 Arpc5 Rac1 Fgfr3 Fgfr1 Vav1 Fgfr2 Pik3r1 Raf1 Fgf15 Pik3cg Kras Apc Pip5k1b Pip5k1a Map2k2 Nras Rras Gna12 Fgf23 Slc9a1 Ins1 Actg1 Chrm1 Chrm3 Chrm2 Chrm5 Chrm4 Gna13 Arhgef1 Was Fgf1 Iqgap1 Pak3 Pik3cb Pik3cd Myl3 Cdc42 Diaph1 Cfl1 Cfl2 Pik3c2b Pik3c2g F2r Myl1 Limk1 Arhgef6 Rock2 Rock1 Pfn1 Rras2 Pik3r2 Fgf5 Git1 F2 Pip4k2a Enah Pdgfrb Ezr Arhgef4 Myh10 Pdgfb Rdx Msn Ssh3 Ssh2 Ssh1 Vil1 Rhoa Cyfip2 Brk1 Mras EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES%WIKIPATHWAYS_20260211%WP4349%MUS MUSCULUS Eicosanoid metabolism via cytochrome P450 monooxygenases Ppara Cyp4a12a Cyp4f14 Cyp4a12b Cyp4a10 Cyp2c29 Ephx2 Cyp2c38 Cyp2c39 Cyp2c37 Cyp2c23 Cyp2c55 Cyp2j5 Cyp2c54 Cyp2c40 Cyp4f3 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260211%WP386%MUS MUSCULUS Triacylglyceride synthesis Plpp3 Plpp1 Dgat2 Agpat2 Gk Gpam Gnpat Pnpla2 Dgat1 Mogat1 Agpat4 Lpl Mogat2 Plpp2 Gk2 Agpat5 Lipc Agps Gpd1 Lipe Agpat3 Lipf Agpat1 IL 4 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP93%MUS MUSCULUS IL 4 signaling pathway Fes Akt1 Jak3 Mapk1 Jak2 Nfkb1 Elk1 Prkcd Pik3r1 Pik3ca Ncf1 Shc1 Rasa1 Ptpn6 Il4 Stam Prkd3 Cbl Sos1 Ptpn11 Rela Fyn Prkcz Hmga1 Pawr Grk3 Mapk14 Il2rg Prkci Lck Il4ra Crebbp Spi1 Mapk3 Grb2 Jak1 Stat6 Tyk2 Bcl2l1 Bad Plcg1 Stat1 Ptk2 Mapk11 Stat5a Rps6kb1 Ep300 Pik3cd Dok2 Il13ra1 Socs5 Atf2 Pik3r2 Src Socs1 Cxcr4 Inpp5d Socs3 Irs1 Irs2 Ets1 P53 SIGNALING%WIKIPATHWAYS_20260211%WP2902%MUS MUSCULUS p53 signaling Atr Igf1 Trp73 Zmat3 Adgrb1 Bbc3 Ccng2 Gadd45b Ddb2 Ccnd1 Serpinb5 Shisa5 Cd82 Ei24 Siah1b Perp Siah1a Thbs1 Pten Rprm Gadd45g Sesn2 Rchy1 Sesn1 Sesn3 Steap3 Rrm2 Pidd1 Gtse1 Cop1 Ccne1 Mdm4 Ccne2 Sfn Ppm1d Pmaip1 Serpine1 Cdkn2a Ccnb2 Ccnb3 Igfbp3 Ccnb1 Apaf1 Ccng1 Tsc2 Chek1 Chek2 Rrm2b Gadd45a Bid Casp8 Bax Casp9 Casp3 Fas Cycs Cyct Ccnd2 Ccnd3 Trp53 Cdk6 Cdk4 Cdk2 Cdk1 Mdm2 Atm Cdkn1a WNT SIGNALING%WIKIPATHWAYS_20260211%WP403%MUS MUSCULUS Wnt signaling Dvl3 Fzd3 Mapk9 Rac1 Csnk1e Prkcd Wnt7a Prkd1 Apc Prkcz Pafah1b1 Fzd1 Frat1 Fzd2 Fosl1 Fzd5 Fzd7 Sfrp4 Jun Fzd9 Prkcq Fbxw2 Ccnd1 Prkcg Prkci Prkch Prkce Fzd10 Myc Wnt1 Wnt10b Gsk3b Ppp2r5c Prkca Ppp2r5e Prkcb Ldlr Wnt11 Wnt5a Wnt6 Wnt7b Wnt5b Wnt10a Wnt2b Wnt16 Ccnd2 Ccnd3 Mapk10 Wnt2 Wnt4 Axin1 Wnt3 Plau Fzd6 Fzd8 Ctnnb1 Wnt3a Rhoa Dvl1 Dvl2 METHYLATION%WIKIPATHWAYS_20260211%WP1247%MUS MUSCULUS Methylation Pnmt Tpmt Inmt Hnmt Mat1a Mat2a Mat2b Nnmt Comt IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP10%MUS MUSCULUS IL 9 signaling pathway Il2rg Stat3 Akt1 Jak3 Mapk1 Stat1 Map2k1 Stat5b Stat5a Mapk3 Grb2 Pik3r1 Jak1 Shc1 Tyk2 Vcp Kat5 Ptpn11 Il9 Il9r Socs3 Irs1 Irs2 Map2k2 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4350%MUS MUSCULUS Omega 3 omega 6 fatty acid synthesis Pla2g6 Acsl1 Acsl3 Acsl4 Acox1 Fads2 Acox3 Pla2g4b Pla2g4a Fads1 Acot1 Elovl2 Acot2 Elovl5 Pla2g5 INSULIN SIGNALING%WIKIPATHWAYS_20260211%WP65%MUS MUSCULUS Insulin signaling Akt1 Mapk9 Flot2 Mapk1 Rps6ka3 Gys1 Mink1 Gys2 Sos2 Elk1 Stxbp3 Prkaa2 Gyg1 Pik3ca Fos Insr Cblb Sos1 Mapk13 Shc2 Map2k4 Jun Mapk14 Prkcq Map3k11 Map3k12 Mapk7 Prkch Map3k13 Mapk6 Stxbp2 Map3k14 Mapk4 Akt2 Map2k1 Pten Sorbs1 Mapk3 Grb2 Hras Mapk8 Shc3 Eif4ebp1 Map2k7 Mtor Cyth3 Stxbp4 Kif5b Flot1 Map4k5 Rab4a Xbp1 Tbc1d4 Ehd1 Gab1 Map4k2 Cblc Ehd2 Snap25 Snap23 Pdpk1 Pfkl Rhoj Rac2 Ptprf Rhoq Cap1 Pfkm Rrad Inpp4a Vamp2 Rps6ka4 Rps6ka6 Prkca Sgk3 Sgk2 Crk Arf6 Igf1r Myo1c Ptpn1 Pik3r4 Stx4 Arhgap33 Prkcb Map2k6 Ppp1cc Map3k10 Map2k5 Mapk12 Map2k3 Rapgef1 Map3k7 Map3k9 Grb10 Eif4e Rps6ka1 Pik3c3 Socs1 Kif3a Socs3 Irs1 Pik3c2a Sh2b2 Arf1 Foxo3 Irs4 Trib3 Rac1 Irs3 Prkcd Pik3r1 Raf1 Shc1 Cbl Ptpn11 Pik3cg Prkcz Enpp1 Slc2a4 Map2k2 Prkci Rps6kb2 Slc2a1 Rps6ka5 Egr1 Foxo1 Rps6ka2 Mapk11 Sgk1 Map3k3 Gsk3b Inppl1 Prkaa1 Grb14 Map3k4 Stxbp1 Tsc2 Tsc1 Rps6kb1 Rheb Pik3cb Map3k2 Pik3cd Lipe Pik3c2g Map3k8 Srf Map3k6 Map3k5 Map3k1 Pik3r2 Mapk10 Map4k4 Map4k3 Ikbkb Map4k1 HYPERTROPHY MODEL%WIKIPATHWAYS_20260211%WP202%MUS MUSCULUS Hypertrophy model Vegfa Zeb1 Mstn Atf3 Jund Eif4e Eif4ebp1 Hbegf Ifng Dusp14 Wdr1 Il18 Ankrd1 Il1a Ifrd1 Ccn1 Nr4a3 Il1r1 Adam10 Myog GLUCURONIDATION%WIKIPATHWAYS_20260211%WP1241%MUS MUSCULUS Glucuronidation Pgm2 Ugt2b34 Ugdh Ugt1a10 Ugp2 Pgm1 Ugt1a1 Hk1 Ugt2a2 Ugt1a2 Ugt2a3 Ugt1a5 Ugt1a8 Ugt2a1 Ugt2b1 Pgm3 Pgm5 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260211%WP441%MUS MUSCULUS Matrix metalloproteinases Mmp12 Mmp7 Mmp1a Mmp9 Mmp23 Mmp24 Mmp25 Mmp27 Mmp28 Bsg Mmp20 Mmp21 Mmp11 Mmp13 Mmp15 Mmp16 Mmp17 Mmp19 Timp2 Mmp8 Timp4 Tcf20 Mmp14 Mmp2 Mmp10 Mmp3 Timp1 Tnf Timp3 REGULATION OF CARDIAC HYPERTROPHY BY MIR 208%WIKIPATHWAYS_20260211%WP1526%MUS MUSCULUS Regulation of cardiac hypertrophy by miR 208 Myh7 Med13 Hopx Gata4 Mstn Gja5 IRON HOMEOSTASIS%WIKIPATHWAYS_20260211%WP1596%MUS MUSCULUS Iron homeostasis Il6ra Hjv Hfe Hamp Slc40a1 Ftl1 Il1a Hamp2 Tf Tfr2 Ireb2 Tnf Fth1 Il6}