S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 Glul ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a5 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI Ldhd GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Acat1 Acat2 Gcdh Echs1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Impa2 Ocrl Pten Impa1 Inpp5k Inpp1 Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5f Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk Bpnt2 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm1 Dut Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Dtymk Nme7 Nme6 Ntpcr Ctps2 Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Fads2 Acsl1 Acsm3 Acsbg1 Acsm4 Slc27a2 Acsm5 Acsbg2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Ggt5 Gstm4 Alox12 Gpx4 Alox5 Dpep1 Alox15 Ltc4s SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Ggps1 Acat1 Hmgcr Acat2 Mvd Hmgcs2 Fdps Idi1 Mvk Pmvk L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Gstz1 Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Tomt Aldh2 Aldh3a2 Adh4 Maoa Pnmt Comt Maob N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Gnpda1 Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Amdhd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Upb1 Dpys Dpyd SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Plcb2 Ip6k2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r4 Pip4k2a Pi4kb Inpp5d Pi4ka Itpka Plch2 Plch1 Inpp5a Plcd1 Plcd4 Synj1 Inpp5b Plcd3 Itpkc Itpk1 Itpkb Cdipt Ipmk Pik3cg Pik3cb Pik3cd Ocrl Pip4p2 Pip4p1 Pten Pik3ca Inpp5k Pi4k2b Plcz1 Pik3c2b Synj2 Inppl1 Plce1 Minpp1 Pik3c2a Pik3c2g Fig4 Pip5kl1 Mtmr3 Ppip5k1 Ppip5k2 Pip5k1c Pip5k1b Pip5k1a L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Aldh4a1 Prodh METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt2 Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss2 Acss1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 Paox L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Tgm1 Aloxe3 Slc27a4 Pnpla1 Cyp4f39 Alox12b Cers3 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis Carns1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Cad Umps Dhodh GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh Nt5c2 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Cat Sod3 Sod2 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Impa2 Impa1 Isyna1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Ndufa10 Cox7b Uqcrfs1 Ndufs1 Ndufs2 Ndufa13 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs8 Coxfa4l2 Uqcrq Coxfa4 Ndufa1 Ndufa3 Ndufa2 Ndufa5 Ndufa7 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cyc1 Ndufb2 Uqcrc2 Ndufb3 Uqcrc1 Ndufb6 Ndufb5 Ndufb8 mt-Nd4l Ndufb7 Ndufb9 Cox6b1 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcrb Uqcr10 mt-Co2 mt-Cytb mt-Co3 mt-Nd4 mt-Nd5 mt-Nd6 Ndufab1 Ndufc1 Ndufc2 mt-Co1 Sdhd Sdhc Sdhb mt-Nd1 Sdha mt-Nd2 mt-Nd3 Ndufa12 Cox6a1 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Nus1 Srd5a3 Dolk Dhrsx Dhdds PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Pfas Ak8 Atic Ppat Paics Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Adsl Impdh1 Guk1 Gart Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 Adss1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk2 Nmrk1 Nmnat3 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glul Glud1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pdx Pgls Pgd UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Coq6 Coq7 Pdss2 Pdss1 Coq2 Ubiad1 Coq3 Coq4 Coq5 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Impdh1 Nme4 Guk1 Nme1 Gmps Nme7 Nme6 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Vps29 Shmt2 Psat1 Shmt1 Phgdh Psph PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Nme3 Nme2 Nme5 Nme4 Guk1 Nme1 Nme7 Nme6 Ak5 Dguok Dck THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Dio1 Dio2 Ugt1a9 Sult1a1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Asns Gls2 Gls VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Nqo1 Ggcx Vkorc1l1 Vkorc1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Cyp1a2 Sult1a1 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Pnp Ada GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Gstz1 Gsta5 Gsta3 Anpep Gstm7 Gstm5 Ggt5 Gstk1 Gstm1 Nat8 Gstm2 Gsto2 Mgst3 Gstt2 Mgst2 Gstt1 Mgst1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Gart ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Alox5 Lta4h Ptgs2 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Azin2 Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Pcyt2 Cept1 Etnk1 Chkb Selenoi CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis Carns1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Tm7sf2 Hsd17b7 Sqle Nsdhl Ebp Lbr Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Dtymk Nme7 Nme6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Alox12 Gpx4 Alox15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Crym Aadat Pycr1 Pipox Dhtkd1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal5 Hyal4 Hyal1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp6v0b ATP6 Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp5pf Atp6v1c1 Atpaf2 Atp6v1a Atp6v1b2 Atp6v0d1 Vps9d1 Atp5mc3 Atp5mf Atp5me Atp6v0e1 Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Fpgs Shmt2 Shmt1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Vps29 Psat1 Phgdh Psph L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Pfas Ppat Gart PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Ggps1 Hmgcr Mvd Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Sqle Ebp Lbr Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Acat1 Acat2 Fdps Idi1 Mvk Pmvk PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Bdh1 Acat1 Hmgcs2 Hmgcl Bdh2 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Dcxr Cryl1 Akr1a1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pi4k2b Plcz1 Plce1 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Plcb4 Plcb3 Plcb2 Plcb1 Pi4k2a Plcg1 Plcg2 Pip4k2b Pip4k2c Pip4k2a Pi4kb Pi4ka Plch2 Plch1 Plcd1 Plcd4 Plcd3 Cdipt ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Aldh2 Aldh3a2 Acss2 Acss1 Cat CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Acat1 Acat2 Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Acadsb Echs1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Fads1 Fads2 Elovl7 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B3galt1 B3gnt5 B3gnt2 Fut2 Fut1 A4galt B4galt4 B4galt6 B4galnt1 Gbgt1 St3gal6 St3gal4 St3gal5 St3gal2 B4galt1 B4galt2 B4galt3 B3galnt1 St6gal1 B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B4galt2 B4galt3 St6gal1 St8sia2 St8sia3 Ugcg B3gnt5 B3gnt2 B4galt4 B4galt6 St3gal6 St3gal4 B4galt1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fpgt Fcsk GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Upb1 Dpys Dpyd S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation Mtap NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt Nadk CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Chdh Aldh7a1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Peds1 Agpat1 Pcyt2 Cept1 Etnk1 Chkb Selenoi Gnpat Pcyt1b Pcyt1a Agps Far2 Far1 Chka L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Afmid Haao Got2 Aldh8a1 Kyat3 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Dhtkd1 Aadat Kyat1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Hsd17b7 Cyp2a5 Cyp19a1 Hsd17b11 Hsd17b3 Hsd17b1 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 Elovl7 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St6gal1 B3galt4 B4galt6 Ugcg B4galnt1 St8sia1 St3gal5 St3gal2 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt1 Abo B3galt5 Fut2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Akr1b10 Cyp2e1 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat2b Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Dhodh Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ippk Itpk1 Ipmk GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Acot2 Scd1 Acot3 Acot4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Tbxas1 Hpgds Hpgd Akr1c18 Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 Cbr1 Ptgs2 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Pip4p2 Ocrl Pip4p1 Pten Inpp5k Synj2 Sacm1l Inppl1 Inpp5e Inpp4a Mtmr14 Mtmr3 Inpp4b Tpte Inpp5d Inpp5f Synj1 Inpp5b ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Tecr Hsd17b12 Elovl4 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcs Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Ephx3 Alox12 Gpx4 Alox5 Alox15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Tbxas1 Hpgds Hpgd Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 Ggt5 Ephx3 Alox8 Gstm4 Alox12 Dpep2 Cyp4f15 Gpx4 Alox5 Cyp2j6 Dpep1 Cyp4f3 Alox15 Cyp2d22 Ltc4s Lta4h Ptgs2 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi6 Padi2 Padi3 Padi4 Padi1 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Ocrl Pten Inpp5k Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k1 Ip6k2 Ip6k3 Ippk Ppip5k1 Ipmk Ppip5k2 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio1 Dio3 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd1 Txnrd3 Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Alox5 Ptgs2 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Bdh1 Acat1 Oxct1 Bdh2 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Dera Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox12 Alox5 Alox15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Maoa Cyp2c50 Cyp1a2 Sult1a1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Aldh8a1 Acmsd Dhtkd1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx3 Gsr Gpx7 Gpx4 Gpx2 Gpx1 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nampt Nmnat1 Nmnat3 Nmnat2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Abhd5 Mboat2 Agpat1 Agpat3 Lclat1 Agpat4 Agpat2 Cds2 Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam Mboat1 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm Minpp1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Aldh3a2 Fa2h Hacl1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Bpgm Gpi Tpi1 Pcx Mdh1 Mdh2 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc2 G6pc3 EG433182 Pgk1 Pgam2 Pgam1 Pgk2 Fbp1 Pck1 Fbp2 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Aoc2 Aldh2 Aldh3a2 Aoc3 Maoa Maob PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Tecr Elovl1 Hsd17b12 Elovl7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Fads1 Fads2 Acsl1 Elovl5 Acsm3 Hsd17b12 Acsbg1 Acsm4 Slc27a2 Acsm5 Elovl7 Acsbg2 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Itpk1 Ipmk &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Ggt5 Gclc Gss Cndp2 Gclm Oplah UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ntpcr Ctps2 Ctps1 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Pygm Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Pygb Mgam Hkdc1 Pygl L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Hibch Acad8 Bckdhb Hibadh Bckdha Aldh6a1 Dbt Bcat1 Dld Abat Bcat2 Echs1 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Ntan1 Ate1 Naa20 Naa25 Ntaq1 Metap1 Apeh Metap2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Alox5 Ptgs2 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1l1 Got1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Hkdc1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II Maoa TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Tsen34 Rtcb Tsen15 Ddx1 AI597479 Rtraf Tsen54 Fam98b Zbtb8os Tsen2 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tk2 Tk1 Dck Tyms PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Rrm1 Dut Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Dtymk Nme7 Nme6 Ntpcr L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Pycr2 Pycr1 Aldh18a1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gsta3 Gsta5 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Nt5c1a Nt5e Nt5c3a Impdh1 Pnp Gda Xdh Nt5c2 Ada L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Ahcy Mat2a Mat2b Mat1a Cbs Cth L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Mtap Mat2a Srm Mat2b Mat1a Enoph1 Adi1 Kyat1 Mri1 Apip D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Impa2 Ocrl Impa1 Inpp5k Inpp1 Synj2 Inppl1 Inpp5f Inpp5a Synj1 Inpp5b Bpnt2 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Bmpr2 Bmp2 Smad4 Acvr2a Bmpr1b Zfyve16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Ggt5 Gstm4 Dpep2 Alox5 Dpep1 Ltc4s Lta4h PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b6 Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Xdh Rbp4 Rbp1 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclc Gss Gclm DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Aldh3a2 Maoa Comt Maob MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Ephx3 Alox12 Alox15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1l1 Got1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis Gal3st1 Ugt8 St3gal5 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldha Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Aldh2 Aldh3a2 Aldh1b1 Aldh3b1 Aldh3a1 Maoa Sat2 Sat1 Maob CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckmt2 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Hmgcll1 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Mccc1 Auh Hmgcl Ivd Mccc2 GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Got1 Aga Aspg Asrgl1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Aldh2 Aldh3a2 Maoa Sult1a1 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Ak8 Adsl Ak1 Ak3 Ak2 Ak5 Adss2 Ak7 Adss1 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat3 Plaat1 Plaat5 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Afmid Haao Kmo Tdo2 Kynu Ido2 Ido1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Plcz1 Plce1 Plaat3 Plaat1 Plaat5 Pla2g2e Pla2g4f Pla2g2d Plcb4 Pla2g2f Plcb3 Pla2g4c Pla2g4e Pla2g4d Pld4 Pla2g4a Plcb2 Pld1 Plb1 Plcb1 Pld3 Pld2 Pla2g12a Pnpla8 Pla2g5 Plcg1 Pla2g3 Plcg2 Pla2g6 Pla2g1b Oc90 Pla2g10 Plch2 Plch1 Plcd1 Plcd4 Plcd3 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Tm7sf2 Hsd17b7 Sqle Nsdhl Ebp Lbr Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Got1 Gclc Gss Gclm COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Ppcs Pank3 Ppcdc Pank2 Coasy Pank1 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Aldob Aldoc Tkfc Aldoa Sis Khk Tpi1 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1 Prps2 Prps1l1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Tk2 Tk1 Tyms Nme3 Nme2 Nme5 Nme4 Cda Cmpk2 Nme1 Cmpk1 Dtymk Nme7 Nme6 Dck PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Cept1 Chkb Pcyt1b Pcyt1a Chpt1 Chka SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Afmid Haao Akr1a1 Nmnat1 Aldh8a1 Kmo Tdo2 Nmnat3 Nmnat2 Kynu Ido2 Acmsd Maoa Ido1 Dhtkd1 Maob Aldh2 Sult1a1 Aanat Tph2 Ddc Tph1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Cyp1a2 Gcdh Echs1 Acat1 Acat2 Aldh3a2 Qprt Nadsyn1 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Scp2 Hsd17b4 Acaa1a Hadh Hsd17b10 Acsbg1 Ehhadh Slc27a2 Acox1 Echs1 Acox2 Acsbg2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Ddc Akr1a1 Aldh3a2 Maob TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Lars2 Gars1 Qars1 Lars1 Vars1 Farsa Farsb Cars2 Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Iars2 Tars1 Ears2 Hars1 Pars2 Mars1 Mars2 Dars2 Yars2 Yars1 Hars2 Dars1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage Pdxk Pnpo N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Gnpda1 Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Ak8 Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Pnp Aprt Hprt1 Ada Adsl Impdh1 Guk1 Adk Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 Adss1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Lass1 Sptlc1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Rrm1 Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Dctd Nme1 Dtymk Nme7 Nme6 Ntpcr UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 Ctps2 Ctps1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Dmgdh Chdh Aldh7a1 Shmt2 Shmt1 Bhmt TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Aco2 Sucla2 Dld Mdh1 Mdh2 Fh Sdhd Idh3a Sdhc Dlst Sdhb Idh3b Sdha Cs Idh3g Suclg1 Suclg2 Ogdh N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 Tsr3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Scp2 Hadh Hadha Hsd17b10 Hadhb Acaa2 Eci1 Acsbg1 Slc27a2 Echs1 Acsbg2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Lass1 Sptlc1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Sord Adh1 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis B3galt1 B3gnt5 St6gal1 B3galt5 Fut2 B4galt6 Ugcg St3gal5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd2 Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Afmid Haao Aldh8a1 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Gcdh Dhtkd1 Echs1 Acat1 Acat2 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Ogt Oga CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Aldh1a2 Rdh16f2 Aldh1a1 Aldh1a3 Sdr16c5 Rbp4 Rbp1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide B4galt2 B4galt3 Abo Fut1 St8sia2 Fut9 Chst1 St3gal4 B4galt1 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Cda Upb1 Upp1 Dpys Upp2 Dpyd THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio1 Dio3 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4galt2 B4galt3 B3gnt2 Gcnt3 Gcnt2 B4galt1 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pfkp Bpgm Gpi Tpi1 Hk3 Hkdc1 Gapdhs Aldob Aldoc Hk2 Eno3 Gck Eno2 Hk1 Aldoa EG433182 Pgk1 Pgam2 Pgam1 Pklr Pgk2 Pfkl Pkm Pfkm HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4galt2 Lalba St6galnac6 St6gal1 B3gnt2 B3galt5 Fut2 B4galt4 Gcnt3 B4galt1 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Nt5e Impdh1 Pnp Xdh Nt5c2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Tyr Dct Trpc1 Tyrp1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Acsf3 Mcat Ndufab1 Oxsm ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation Faah FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd Adh5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galnt1 B3galt5 Fut2 Fut1 A4galt B4galt6 Ugcg Gbgt1 St3gal2 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Hk2 Gck Hk1 Treh Hk3 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Ephx3 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rbp2 Rbp3 Rdh5 Dhrs9 Lrat Rlbp1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 Rpe65 Rbp1 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Srd5a1 Srd5a2 Akr1c18 Cyp17a1 Hsd3b6 Hsd3b1 Hsd17b3 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Nme3 Nme2 Nme5 Impdh1 Nme4 Guk1 Nme1 Gmps Nme7 Nme6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 Rbp1 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Ephx3 Alox12 Gpx4 Alox5 Cyp2d22 Alox15 Ptgs2 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3cd Pik3ca Pi4k2b Pik3c2b Pik3c2a Pik3c2g Fig4 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Pikfyve Pik3c3 Sacm1l Pi4k2a Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pik3r2 Pik3r4 Pi4kb Pi4ka Cdipt Pik3cg Pik3cb UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Uap1 Pgm3 Hk2 Gnpda1 Gck Hk1 Gnpda2 Gpi Hk3 Gale Hkdc1 Gnpnat1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis Hkdc1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Got1 Cdo1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Elovl6 Acot7 Acsl1 Hsd17b12 Acsbg1 Acot2 Slc27a2 Acot3 Acot4 Elovl7 Acsbg2 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Aldh4a1 Got2 Hoga1 Prodh2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f15 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Acsl1 Ptgr1 Acsbg1 Slc27a2 Acsbg2 Acer1 Acer2 Asah2 Asah1 Sphk2 Sphk1 Sgpp2 Sgpp1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Pnp Pgm2 Ada PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Cda Upp1 Upp2 Tymp D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Pip4p2 Pip4p1 Plcb2 Plcz1 Plcb1 Plce1 Plcg1 Plcg2 Mtmr14 Mtmr3 Pip4k2c Pip4k2a Plch2 Plch1 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Srd5a1 Akr1c6 Srd5a2 Akr1c18 Akr1c21 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Mthfd2l Aldh1l1 Mthfsl Aldh1l2 Mthfd2 Mthfr Shmt2 Shmt1 Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat2b Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Pnp Hprt1 Ada REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Gpx3 Gpx7 Gpx6 Cat Gpx5 Gpx8 Sod3 Gpx2 Sod2 Gpx1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Nt5c1a Nt5e Nt5c3a Pnp Xdh Nt5c2 Ada ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Akr1b10 Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Aldh9a1 Shmt1 Tmlhe Bbox1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Ocrl Inpp5k Synj2 Inppl1 Ippk Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpk1 Itpkb Ipmk LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Alox8 Alox12 Gpx4 Alox5 Alox15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Daglb Cel Pnliprp2 Pnlip Lipc Pnpla2 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Nanp Nans Cmas Gne CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Ptpmt1 Crls1 Pgs1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Nmnat3 Nmnat2 Qprt Nadsyn1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis Cox10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Fads2 Elovl2 Elovl5 Hsd17b12 Elovl7 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4galt2 B4galt3 St6gal1 B3gnt2 St8sia2 Gcnt3 Gcnt2 St3gal4 B4galt1 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Aldh2 Aldh3a2 Cyp2e1 Acss2 Acss1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Aldh2 Aldh3a2 Acss2 Acss1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Mcee Dld Pcca Pccb Mmut LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1l3 Glb1 Lct NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Fmo3 Fmo2 Fmo5 Fmo4 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 Ugt1a5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Pgm1 Galt Galm Galk1 Pgm2 Gale UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Uap1 Pgm3 Hk2 Gck Hk1 Gfpt1 Gpi Gfpt2 Hk3 Hkdc1 Gnpnat1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt2 Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Atic Adsl Paics L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Aadat Aldh7a1 Aass Dhtkd1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sars2 Sars1 Pstk Sephs2 Sephs1 Sepsecs FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Phyh Acsm1 Aldh3a2 Hacl1 Slc27a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis Glul TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Ggps1 Fdps THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Tyw1 Lcmt2 Tyw3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Napepld Gde1 Plaat1 Enpp2 Plaat5 Pla2g1b VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Acat1 Acsm1 Acat2 Acadsb Echs1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Afmid Haao Nmnat1 Kmo Tdo2 Nmnat3 Kynu Nmnat2 Ido2 Qprt Ido1 Nadsyn1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsl3 Acsl1 Acsbg1 Slc27a2 Acsbg2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Dagla Plcb1 Daglb Ddhd1 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) Slc34a2 Aqp7 Slc2a1 Pnp Hemk2 Slc20a2 Slc20a1 Trmt112 Aqp9 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp2b10 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation Adh5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm1 Ugp2 Pgm2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Alox5 Lta4h Ptgs2 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 Papss1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Gmppb Gpi Pmm1 Mpi CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Tm7sf2 Hsd17b7 Sqle Nsdhl Ebp Lbr Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss UREA CYCLE%BIOCYC%PWY-4984 urea cycle Asl Cps1 Ass1 Otc GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Dmgdh Shmt2 Shmt1 Bhmt SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Suox Tst Sqor HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Alad Alas1 Alas2 Hmbs Fech Cpox Uros Urod Ppox PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Mcee Pcca Pccb Mmut L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Sds Bckdhb Bckdha Dbt Sdsl Dld GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Pnp Hprt1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Nos3 Nos2 Nos1 Asl Ass1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Got1 Bckdhb Bckdha Dbt Cbs Mcee Cth Dld Bhmt Pcca Bhmt2 Pccb Mtr Mmut Suox Cdo1 Ahcy Mat2a Mat2b Mat1a TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas1 Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Acat1 Hmgcr Acat2 Mvd Hmgcs2 Idi1 Mvk Pmvk TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Ppcs Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Agpat1 Plpp4 Plpp2 Plpp3 Plpp1 Mogat1 Dgat2 Plppr4 Dgat1 Plppr2 Plppr3 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam Mboat1 Abhd5 Mboat2 Agpat3 Lclat1 Agpat4 Agpat2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis Flad1 Rfk D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Minpp1 Itpk1 Ipmk CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh Pnmt 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw1 Tyw3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Cdo1 Fmo1 Csad ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Got1 Mdh1 Mdh2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor Bcar1 Fzr1 Ncoa1 Ap2b1 Arrb2 Fosb Cd44 Runx2 Kat2b Rb1 Mapk14 Tgfbr3 Prkar2a Pml Ski Map2k3 Mef2a Mef2c Brca1 Zfyve9 Rock1 E2f4 Tgfbr1 Cdkn1a E2f5 Tgfbr2 Atf2 Mapk8 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Ctnnb1 Map3k7 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Myc Cdc27 Akt1 Sox9 Cdc23 Skp1 Pdk1 Pard6a Dcp1a Rbx1 Prkcg Eid2 Prkcb Hgs Ube2d3 Prkcd Ube2d1 Nup153 Trp73 Btrc Cdc25a Atf3 Jund Sdc2 Pxn Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Ar Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Vdr Trp53 Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Ptk2 Stk11 Hspa8 Crebbp Smad2 Map4k1 Nup214 Smad3 Wwtr1 Sparc Smad4 Cdk6 Fnta Cdk4 Cdk2 Cul1 Cdc16 Cdk1 Tab1 Junb Daxx Smad6 Smad7 Hnf4a Rhoa Tgif1 Ing2 Xpo1 Xpo4 Ctcf Hdac1 Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Rbl2 Zeb2 Rbl1 Anapc10 Foxh1 Smurf2 Smurf1 Skil Pik3r1 Crk Pik3r2 Eng Lef1 Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Nfyc Prkar1b Ep300 Strap Map2k6 BDNF%IOB%BDNF BDNF Ptk2b Irs2 Elk1 Gsk3b Ntrk2 Ntrk1 Mapk3 Raf1 Akt1 Mapk9 Mapk8 Shc4 Mapk7 Shc1 Irs1 Mapk1 Foxo3 Plcg1 CCR1%IOB%CCR1 CCR1 Pxn Ptk2b Mapk3 Ccr1 Zap70 Creb3 Mapk14 Src Gna14 Rela Ccl7 Ccl5 Ccl4 Ccl3 Nfkb1 Stat1 Prkcd Ptk2 Mapk1 LEPTIN%IOB%LEPTIN Leptin Stat3 Grb2 Lepr Mapk3 Mapk14 Prkcd Irs1 Irs2 Sp1 Pik3r1 Pik3r2 Pde3a Itgav Socs7 Ncoa3 Ptpn11 Slc2a4 Jak3 Jak2 Egfr Ptk2 Khdrbs1 Itgb5 Mapk1 Lep Prkce THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin Stat3 Map2k1 Stat5b Atxn2l Mpl Mapk3 Gab1 Jak2 Shc1 Mapk1 Foxo3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor Akt1 Mapk14 Prkcb Shc1 Plcg1 Gsk3b Raf1 Src Rela Stat1 Jun Ptpn11 Jak3 Jak2 Grb2 Stat5b Socs1 Mitf Socs5 Socs4 Matk Socs6 Crkl Ptpru Gys1 Cltc Sh3kbp1 Cblb Mad2l1 Fgr Hck Dok1 Wipf1 Rps6ka1 Tnfrsf10b Kit Prkca Spred1 Il7r Sos1 Spred2 Inpp5d Grb7 Rasa1 Was Eif4ebp1 Cbl Mtor Epor Csf2rb2 Abl1 Fyn Grap Lyn Kitlg Pik3r1 Yes1 Crk Pik3ca Pik3r2 Stat5a Tec Fes Hras Atf2 Mapk8 Ep300 Mapk1 CCR7%IOB%CCR7 CCR7 Ptk2b Foxo1 Gsk3b Mapk3 Mtor Mapk14 Akt1 Rela Cfl1 Ccr7 Adrb2 Mapk8 Mapk1 Foxo3 Plcg1 WNT%IOB%WNT Wnt Ctnnb1 Pi4k2a Map3k7 Rac1 Ppp1ca Nfatc2 Sfrp2 Arrb2 Ppp2ca Sfrp1 Daam1 Rspo1 Prkaca Akt1 Dkk1 Mesd Pax2 Gsk3a Frzb Dixdc1 Chd7 Axin1 Prkcg Ror1 Ror2 Prkcb Gckr Lrp1 Arhgef4 Prkcd Lrp6 Csnk1a1 Nlk Lrp5 Wnt3a Dvl1 Dvl2 Gpc3 Dvl3 Wnt7a Wnt2 Wnt1 Gsk3b Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd3 Fzd5 Jup Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Fzd8 Smad1 Bcl9 Apc Jun Pin1 Tcf4 Pip5k1b Ccnd1 Cdk6 Rhoa Prkca Yes1 Lef1 Ilk Mark2 Mapk8 Sox1 Wnt5a Ctbp1 Cdh1 Setdb1 Ywhab FAS%IOB%FAS Fas Fas Rac1 Pkn2 Pkn1 Vim Dffa Cdk11b Mapk3 Cdc27 Akt1 Rock1 Prkcd Csnk1a1 Gsk3b Traf3 Psme3 Faf1 Eif2ak2 Arhgdib Stk24 Map3k5 Xpo5 Parp1 Traf2 Traf1 Dedd2 Plec Csnk2b Map2k1 Prkn Parg Rfc1 Mst1 Bcl2l1 Xiap Glrx Casp8ap2 Eif3j2 Eif4b Gtf3c3 Lck Tcp1 Daxx Btk Anxa4 Fadd Top1 Met Csnk1e Cast Dedd Cd59b Max Srf Aifm1 Uso1 Ptpn6 Uba7 Stk4 Stk3 Prkdc Rasa1 Ripk2 Fasl Numa1 Hspb1 Cflar Eif2s1 Bid Pak2 Fyn Casp8 Casp7 Lyn Tial1 Mbd4 Tia1 Casp9 Casp4 Casp3 Casp6 Fastk Satb1 Casp2 Casp1 Ripk1 Bmx Map2k2 Wee1 Diablo Pdcd6 Mapk1 Bax Bcl2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Rac1 Vim Erbb2 Clca1 Rpsa Ywhah Ywhae Akt1 Erbin Dsp Eif4e Lama5 Cd151 Itgb4 Lama2 Lama3 Mst1r Mylk3 Ywhaz Col17a1 Prkcd Itga6 Ntn1 Ephb2 Trp73 Pak1 Lamb2 Lamb3 Shc1 Pik3cg Irs1 Sfn Lamb1 Pik3cb Irs2 Pik3cd Rtkn Bad Eif6 Lamc1 Lamc2 Ar Src Ptpn11 Egfr Ptk2 Smad2 Grb2 Plec Smad3 Rhoa Met Prkca Eif4ebp1 Mtor Abl1 Fyn Pik3r1 Yes1 Pik3ca Pik3r2 Casp3 Ywhab NGF%IOB%NGF NGF Elk1 Map2k1 Mapk3 Creb1 Dnaja3 Prkci Frs2 Mapk1 Sp1 HEDGEHOG%IOB%HEDGEHOG Hedgehog Ctnnb1 Gas1 Kif27 Arrb2 Prkaca Ywhae Med23 Dhh Ihh Gli1 Gli3 Gli2 Shh Grk2 Ptch2 Ptch1 Dyrk1a Boc Med12 Med1 Hhip Stk36 Med6 Cdk8 Smo Sap18b Sufu GM-CSF%IOB%GM-CSF GM-CSF Bcar1 Mapk3 Akt1 Mapk14 Tgfbr3 Gsk3a Map2k3 Mapk9 Shc1 Plcg1 Pxn Elk1 Gsk3b Bad Raf1 Creb1 Tgfb1 Stat1 Jak2 Stat3 Grb2 Ikbkb Pdia3 Map2k1 Csf2ra Stat5b Slc2a1 Prdx3 Stam2 Gab1 Syk Rack1 Vav1 Sptan1 Rps6ka2 Ezr Crkl Pfn1 Csf2 Ganab Stam Cct5 Dpysl2 Ptprc Sh2b2 Hck Nfkbia Bcl3 Hnrnph1 Park7 Chuk Prkca Ptpn6 Cbl Csf2rb2 Lyn Pik3r1 Yes1 Pik3r2 Stat5a Fes Mapk8 Map2k2 Mapk1 Map2k6 CCR9%IOB%CCR9 CCR9 Ccl25 Foxo1 Itga4 Ccr9 Gsk3b Mapk3 Mapk14 Akt1 Ezr Mapk8 Rdx Madcam1 Msn Cdh1 Mapk1 Cd226 Itgb7 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK Grb7 Elk1 Nos3 Map2k1 Tie1 Stat5b Dok2 Mapk3 Tek Raf1 Nck1 Mapk14 Akt1 Stat5a Fes Bmx Pak1 Map2k2 Ptk2 Shc1 Mapk1 CCR5%IOB%CCR5 CCR5 Stat3 Grb2 Ikbkb Mapk3 Syk Akt1 Mapk14 Nfkbia Chuk Ptpn6 Ptk2b Psma5 C5ar1 Afp Ccl11 Cd4 Rela Ccl12 Ccl7 Ccl5 Ccl2 Ccl4 Ccr5 Pik3r1 Stat5a Stat1 Cfl1 Mapk1 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha Stat3 Stat5b Akt1 Vav1 Eif4b Crkl Map2k3 Nfkbia Prkcd Irs1 Foxo1 Irs2 Eif4ebp1 Cbl Mtor Zap70 Stat6 Crk Stat4 Stat5a Erbb3 Stat1 Pla2g4a Ifnar1 Ifnar2 Jak1 Arhgap30 Tyk2 Prkcq Map2k4 Rps6ka5 Stat2 Map2k6 TRAIL%IOB%TRAIL TRAIL Bex3 Ctnnb1 Chek2 Map3k7 Ikbkg Tnfrsf11b Prkaa1 Tradd Mapk3 Bak1 Bcl10 Mcl1 Xiap Vdac1 Akt1 Mapk14 Tnfsf10 Apaf1 Irf5 Atm Fadd Nfkbia Tnfrsf10b Aifm1 Prkdc Cbl Cflar Creb1 Bid Src Casp8 Casp7 Rela Nfkb1 Casp3 Casp2 Casp1 Ripk1 Diablo Ctsb H2ax Mapk1 Parp1 Bax Dap3 Traf2 NOTCH%IOB%NOTCH Notch Mapk3 Kat2b Skp1 App Sin3a Fhl1 Hivep3 Rbx1 Hdac2 Mfng Hey1 Numb Ccn3 Skp2 Sap30 Hes6 Tle1 Maml3 Notch4 Fbxw7 Notch1 Notch2 Notch3 Psen1 Pofut1 Gsk3b Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Dll1 Dll3 Rela Dll4 Itch Maml1 Ring1 Maml2 Smad1 Nfkb1 Hes1 Furin Jag2 Jag1 Cirsr Rbpj Yy1 Lfng Tcf3 Jak2 Stat3 Smad3 Smad4 Cul1 Hdac1 Lef1 Ep300 Mapk1 M-CSF%IOB%M-CSF M-CSF Gab3 Stat3 Pstpip2 Grb2 Dnm1 Csf1 Vim Stat5b Mitf Akt1 Fadd Prkcd Shc1 Ptk2b Inpp5d Cbl Casp8 Pik3r1 Stat5a Ptpn11 Ripk1 Ets2 Csf1r Myo18a Ptk2 Inppl1 Grap2 Tfe3 EGFR1%IOB%EGFR1 EGFR1 Mapk8 Mapk1 Mapk3 Myc Akt1 Prkcg Prkcb Hgs Prkcd Jund Pxn Dab2 Sp1 Jun Trp53 Cav1 Ptk2 Stk11 Smad2 Smad3 Cdk2 Cdk1 Rhoa Tgif1 Hdac1 Zfyve16 Foxo1 Fos Pik3r1 Crk Pik3r2 Bcar1 Ap2b1 Mapk14 Map2k3 Mapk9 Mapk7 Shc1 Plcg1 Ptk2b Irs2 Elk1 Gsk3b Raf1 Src Rela Nfkb1 Stat1 Ptpn11 Jak2 Egfr Khdrbs1 Stat3 Grb2 Map2k1 Stat5b Gab1 Socs1 Crkl Cltc Sh3kbp1 Cblb Dok1 Rps6ka1 Kit Prkca Sos1 Grb7 Rasa1 Eif4ebp1 Cbl Mtor Abl1 Fyn Lyn Pik3ca Stat5a Hras Cfl1 Ctbp1 Cdh1 Ywhab Rac1 Gsk3a Arhgef4 Jup Plec Lck Anxa4 Met Cd59b Ptpn6 Casp9 Ripk1 Map2k2 Bcl2 Pkn2 Vim Erbb2 Erbin Dsp Itgb4 Ywhaz Col17a1 Ephb2 Pak1 Pik3cg Pik3cb Pik3cd Bad Creb1 Prkci Frs2 Grk2 Dyrk1a Stam2 Vav1 Rps6ka2 Pfn1 Stam Nos3 Dok2 Nck1 Erbb3 Jak1 Tyk2 Rps6ka5 Stat2 Prkaa1 App Itch Inppl1 Dnm1 Myl12b Il17rd Pard3 Mprip Prkd1 Elk4 Eps8 Gja1 Tfg Ralb Otud6b Araf Plcg2 Arhgap5 Itsn2 Arap1 S100a14 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot2 Flot1 Errfi1 Myo6 Scrib Prkcz Tfrc Garem1 Pik3c2b mt-Co2 Antxr1 Arf4 Braf Shb Clta Pgam1 Cyld Ldha Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl1 Appl2 EG433182 Caskin2 Stx4 Pygb Gsn Pdzd11 Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Abi1 Ensa Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Socs3 Atxn2 Grb14 Grb10 Phpt1 Stip1 Map3k4 Pias3 Cdh3 Cdh2 Plekhn1 Eps15 Map3k3 Magi1 Map3k2 Map3k1 Hat1 Pkp2 Hnrnpdl Ldlr Pkp4 Pkp3 Flnb Anxa2 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Abl2 Serpinb3d Slc38a2 Ptpre Tnk2 Ptpra Cdk5 Alb Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Acp1 Sh3gl3 Adam9 Epha1 Epha2 Epha4 Itgb1 Pkm Dsg2 Sh3gl2 Sos2 Ctnnal1 Ubash3b Wbp2 Atp1a1 Sri Ephb1 Cebpb Cebpa Ephb3 Ephb4 Ahcyl1 Hnrnpa1 Ptpn1 Slitrk6 Csk Arhgap32 Arhgap35 Rbbp7 Tagln2 Pten Sh2b1 Ralbp1 Bcar3 Slc25a5 Spart Nectin1 Rps10 Ppp2r3a Prkaa2 Scamp3 Tns4 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Rin1 Tln1 Vasp Arhgef7 H3c8 Hnrnpr Sdc4 Sdc3 Insr Atp5f1c Usp6nl Pttg1ip Slc5a5 Snx5 Tollip Ptk6 Pdcd6ip Kirrel1 Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Dyrk1b Ptprk Dcbld2 Ptprf Git1 Rps27l Vav3 Laptm4a Cdv3 Plekha6 Plekha5 Vav2 Mink1 Actn1 Prpf4b Actn4 Plscr1 Gprc5a Aldoa Map2k7 Map2k5 Limd1 Cstb Git2 Krt18 Krt17 Racgap1 Wasl Cttn Mpzl1 Axl Ctnnd1 Nedd9 Huwe1 Tjp2 Cavin1 Cavin2 Sdcbp Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Sirpa Ralgds Dlg3 Crim1 Ddx6 Peak1 Afap1l2 Ddx3x Sfpq Pdpk1 Dapp1 Iqgap1 Asap1 Anks1 Asap3 Baiap2 Lsr Epn2 Epn1 Dyrk4 Rps6ka3 Epn3 Dock4 Usp31 Dyrk3 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Ptpn18 Rgs16 Ptpn12 Mta2 Egf Spry2 Spry3 Spry1 Reps2 Prag1 Spry4 Pebp1 Ptpn23 Zpr1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor Trim68 Bag1 Gtf2h1 Ncoa1 Psmc3ip Rbak Ccnd3 Cdk11b Nelfcd Pelp1 Runx2 Cdk9 Kat2b Xrcc6 Rb1 Cdk7 Hspa5 Xrcc5 Mdm2 Fhl2 Pias3 Pou2f1 Prmt1 Rac3 Rnf14 Brca1 Calr Nr0b2 Spdef Etv5 Efcab6 Lpxn Svil Ddc Il6st Tmf1 Arnt Hsp90b1 Zmiz2 Zmiz1 Rnf4 Foxa1 Gsk3b Magea13 Ncoa2 Ncoa6 Nsd2 Nsd1 Pnrc1 Pak6 Src Stub1 Tgfb1i1 Rela Slc25a4 Vip Rchy1 Ran Ncoa3 Egfr Stat3 Cebpa Rack1 Pten Park7 Ccne1 Ctnnb1 Ppp1ca Akt1 Sin3a Cdc25a Pxn Ar Ncor2 Sp1 Jun Tcf4 Ccnd1 Cav1 Esr1 Hspa8 Parp1 Smad3 Smad4 Prkd1 Daxx Top1 Tgif1 Hdac1 Brinp1 Nr2c2 Hspb1 Nr2c1 Nrip1 Ahr Hsp90aa1 Uxt Casp8 Pias4 Casp7 Kat5 Ube2i Kat7 Pik3r1 Gtf2f2 Gtf2f1 Pias1 Casp3 Sf1 Appl1 Ccnh Prdx1 Tle5 Patz1 Casp1 Dapk3 Flna Gsn Cdc37 Pa2g4 Ranbp9 Senp1 Ep300 Cdc25b Nono FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 Stat3 Cebpa Cbl Mapk3 Creb1 Gab1 Akt1 Lyn Flt3 Gab2 Stat5a Jun Cblb Atf2 Mapk1 CD40%IOB%CD40 CD40 Stat3 Ikbkb Map2k1 Mapk3 Syk Myc Mapk14 Akt1 Fyn Lyn Lck Pik3r1 Plcg2 Jun Fgr Nfkbia Jak3 Mapk9 Mapk8 Chuk Mapk1 TNFSF3%IOB%TNFSF3 TNFSF3 Rela Nfkb1 Traf5 Jun Relb Tnfrsf1b Tnfrsf1a Traf3 Nfkbia Nfkb2 Lta Ltb Ltbr Traf2 ID%IOB%ID ID Id4 Id3 Elk1 Myf5 Smad3 Tcf7l2 Rbl2 Rb1 Elk4 Rbl1 Cdk2 Hes1 Tcf3 Myod1 Psmd4 Pax5 Elk3 Atf3 Id2 Id1 G-CSF%IOB%G-CSF G-CSF Stat3 Grb2 Il3ra Csf3r Stat5b Pom121 Mapk3 Fth1 Pla2g1b Socs3 Syk Syp Rel Akt1 Mapk14 Cdk2 Cish Cdkn1b Csf3 Lck Hck Csnk1e Rps6ka1 Shc1 Inpp5d Cbl Prkci Lyn Gab2 Stat5a Stat1 Jak1 Ptpn11 Tyk2 Jak2 Mapk1 EPO%IOB%EPO EPO Stat3 Map2k1 Stat5b Mapk3 Gab1 Syk Akt1 Vav1 H2bc7 Gsk3a Crkl Hcls1 Sgk1 Sh2b2 Foxo4 Foxo3 Foxo1 Irs2 Bad Nos3 Braf Raf1 Mtor Epor Stat5a Jun Ptpn11 Jak2 Map2k2 Rps6ka5 Mapk1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma Stat3 Cebpb Mapk3 Akt1 Mapk14 Crkl Spi1 Plcg2 Ifngr1 Hoxa10 Irf1 Irf2 Irf8 Mapk11 Cbl Raf1 Stat6 Crk Stat5a Stat1 Pla2g4a Jak1 Prkcq Mapk8 Jak2 Egfr Mapk1 TNFSF1%IOB%TNFSF1 TNFSF1 Ikbkg Akt1 Rela Nfkb1 Traf5 Jun Relb Tnfrsf1b Tnfrsf1a Traf3 Nfkbia Nfkb2 Tnfrsf14 Lta Ltbr TNFALPHA%IOB%TNFALPHA TNFalpha Pkn1 Map3k14 Cdk9 Ywhah Rb1 Ywhae Mapk14 Pml Map3k3 Ywhaz Map3k2 Map3k1 Mapk9 Creb1 Src Rela Nfkb1 Traf5 Stat1 Relb Tnfrsf1b Tnfrsf1a Nfkb2 Ptpn11 Egfr Ikbkb Gab1 Syk Rel Rack1 Nfkbia Dok1 Bcl3 Rpl4 Nkiras1 Nkiras2 Chuk Tbkbp1 Trib3 Map3k8 Nlrp4e Rps11 Tnf Fbl Unc5cl Tbk1 Tnfrsf11a Akt2 Dpf2 Kcnq1 Azi2 Polr1b Ppp1r13l Polr1c Polr1a Usp2 Polr1d Polr1e Fbxw11 Txlna Stat5a Tank Gtf2i Hsp90ab1 Actl6a Smarce1 Tifa Cdc34 Rasa3 Mark2 Mapk8 Nfkbiz Papola Rps6ka5 Glg1 Bag4 Mapk1 Sec16a Ripk3 Ywhab Cradd Map3k7 G3bp2 Dcaf7 Ikbkg Cops3 Nfkbib Nfkbie Tradd Mapk3 Kpna6 Kpna3 Ccnt1 Tab3 Akt1 Tab2 Traf7 Traf4 Skp1 Pfdn2 Traf6 Birc2 Tnfrsf8 Ikbke Ywhag Hdac2 Psmd12 Copb2 Map2k5 Smarcb1 Ube2d3 Psmd13 Prkcd Alpl Rasal2 Akap8 Hdac6 Btrc Iqgap2 Psmb5 Peg3 Fbxw7 Bcl7a Ppp6c Nupr1 Fkbp5 Smarca4 Mcm5 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Psmd7 Psmd6 Mapkapk2 Fancd2 Psmd3 Jun Psmd2 Cops5 Elp1 Psmd1 Traf3 Ktn1 Spag9 Cav1 Faf1 Usp11 Glb1 Smarcc2 Prc1 Ddx3x Smarcc1 Rnf25 Map3k11 Crebbp Traf2 Tnfaip3 Traf1 Lrpprc Mtif2 Cul1 Tab1 Fadd Hdac1 Prkcz Brinp1 Nr2c2 Hspb1 Cflar Bid Hsp90aa1 Casp8 Casp7 Ube2i Casp3 Casp2 Ripk1 Flna Cdc37 Map2k6 GDNF%IOB%GDNF GDNF Pxn Ptk2b Bcar1 Ret Map2k1 Th Cdc25c Raf1 Gab1 Rps6ka3 Fyn Cdk1 Crk Jun Met Nfkbia Dok1 Map2k2 Ptk2 TNFSF8%IOB%TNFSF8 TNFSF8 Traf1 Tnfrsf8 Nfkb1 Relb Traf3 Nfkb2 Bcl3 Rel Akt1 Rela Mapk1 CXCR4%IOB%CXCR4 CXCR4 Bcar1 Rac1 Arrb2 Mapk3 Vav2 Map2k3 Prkcd Plcg1 Pxn Ptk2b Elk1 Gsk3b Bad Creb1 Zap70 Src Rela Nfkb1 Stat1 Ptpn11 Jak3 Jak2 Egfr Ptk2 Hspa8 Stat3 Ikbkb Map2k1 Stat5b Itk Cxcr4 Itgb2 Icam1 Gnai1 Vav1 Tff2 Lcp2 Rps6ka2 Cxcl12 Gna13 Crkl Grk6 Lck Fyb1 Plcg2 Ackr3 Esr2 Vcam1 Cblb Limk1 Rhoa Ptprc Usp14 Nfkbia Dok1 Chuk Foxo3 Ptpn6 Inpp5d Rasa1 Was Cbl Nck1 Fyn Lyn Sdc4 Ccr5 Pik3r1 Crk Stat4 Pik3r2 Cfl1 Map2k2 Stat2 Mapk1 Ywhab CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 Il4 Cabin1 Pou2f1 Ifng Fasl Cd40lg Akap5 Nfatc1 Csf2 Junb Nfatc3 Ptgs2 Nfatc2 Rcan1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Jun Fos Atf2 Il10 Sin3a Sin3b Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Tgif2 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Tfdp1 Foxo3 Foxo1 Creb1 Sap30 Col1a2 Tfe3 Dcp1a Rbl1 Itgb5 Sap18b Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Ncor1 Dlx1 Nr3c1 Myod1 Max Ep300 Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Cited1 Sp3 Runx3 Runx2 Kat2b Kat2a Cbfb Vdr Rbbp4 Rbbp7 Esr1 Hspa8 Crebbp Ski Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 E2f4 Tcf3 Cdkn1a E2f5 Smad7 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Nfkbia Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il12b Il18 Il18rap Il19 Cd3e Tnf Mpo Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Cxcl3 Jak2 Il12rb1 Pik3ca Tyk2 Nos2 Il24 Il17f Il23a Rela Il17a SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Hdac1 Ranbp2 Hdac4 Ube2i Mdm2 Pias1 Ran Pias2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Jun Pik3r1 Fos Mapk8 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Cd44 Vav3 Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Itgb3 Rock2 Chuk Pip5k1a Map3k14 Nfkb1 Pik3ca Rela ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Fkbp1a Mapk1 Mapk3 Smad4 Smad7 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Ppp1ca Csnk2b Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 Eng SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Irs1 Src Jun Pxn Irs2 Grb10 Gdnf Ptpn11 Prkaca Pik3r1 Gfra1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Mapk8 Dok5 Mapk1 Dok6 Grb2 Prkca Mapk3 Sos1 Rhoa Crk Bcar1 Hras Rac1 Creb1 Pik3ca Ret Grb7 Shank3 Shc1 Rasa1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Prkaca Mapk1 Mapk3 Fgf15 Col11a1 Col11a2 Cask Ccl5 Bsg Hpse Ppib Col2a1 Mmp9 Sdcbp Col3a1 Mmp7 Col1a1 Col6a1 Col5a2 Col4a3 Tgfb1 Col4a4 Col7a1 Col6a2 Hgf Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Col1a2 Fgf23 Fgfr3 Fgfr4 Mmp1a Lama5 Sdc1 Met REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Plce1 Lgals1 Lgals3 Rasgrf1 Nras Prkcb Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Sos2 Grb2 Prkca Sos1 Hras Rasa2 Rasa4 Rabgef1 Camk2b Rasal1 Nf1 Dab2ip Kras Prkcz Rasa1 Syngap1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Incenp Aurkb IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Stat5a Pik3r1 Il4 Cd40lg Socs1 Spi1 Stat6 Alox15 Ets1 Socs5 Myb Jak3 Il10 Aicda Jak1 Il13ra1 Il13ra2 Arg1 Bcl2l1 Fcer2a Mybl1 Dok2 Irf4 Itgb3 Lta Oprm1 Tff3 Inpp5d Ptpn6 Akt1 Thy1 Ccl17 Cbl Mtor Selp Ccl11 Gtf3a Pigr Col1a2 Mapk14 Egr2 Parp14 Il2rg Stat5b Bcl6 Fes Il4ra Hmga1 Retnlg Shc1 Irs1 Irs2 Cebpb Il5 Sp1 Grb2 Col1a1 Socs3 Jak2 Pik3ca IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Lck Bcl2 E2f1 Ugcg Il2ra Ptpn11 Pik3r1 Il2 Grb2 Sos1 Myb Rac1 Jak3 Jak1 Bcl2l1 Myc Akt1 Mtor Foxo3 Il2rg Nfkb1 Pik3ca Smpd1 Il2rb Eif3a Hsp90aa1 Sgms1 Shc1 Prkcz Gab2 Rela Tert SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Nras Il2ra Stat1 Prkaca Pik3r1 Il2 Ifng Rhoa Jak3 Jak1 Il2rg Il2rb Gab2 Shc1 Irs1 Lck Bdnf Afdn Kdr Ptpn11 Angpt1 Lmo4 Ngf Gab1 Frs3 Frs2 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Ntf4 Grb2 Ntf3 Sos1 Pdgfrb Ifngr1 Vegfa Hras Pdgfb Pag1 Arhgap35 Nos3 Egf Igf1 Ntrk2 Map2k2 Ntrk1 Map2k1 Il6ra Ntrk3 Tek Igf1r Il6 Jak2 Pik3ca Kras NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Cdkn1b Ep300 E2f1 Ar Stat3 Ncoa1 Kdr Runx2 Myb Crebbp Tcf3 Ctbp1 Spen Neurog3 Hdac1 Ncor2 Arnt Ptf1a Camk2d Ghr Hif1a Maml1 Hey2 Maml2 Cd4 Hey1 Parp1 Hes1 Twist1 Ascl1 Rb1 Hes6 Jak2 Tle1 Gaa Rbbp8 Kdm1a Rbpj Yy1 Ncor1 Notch1 Gata6 Gata4 Rcan1 Myod1 Gata1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itga7 Itga8 Itgax Itga5 Itga6 Itga9 Itgam Itga4 Itga1 Itga2 Itgae Itgal Itga10 Itga11 Itgad Itgb8 Itgb6 Itgav Itgb7 Itgb1 Itga2b Itgb4 Itgb2 Itgb3 Itga3 Itgb5 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Incenp Rhoa Golga2 Nudc Bora Kif2a Kif20a Fbxo5 Spc24 Ercc6l Ppp1r12a Fzr1 Pak1 Ect2 Rock2 Tubg1 Bub1 Cdc14b Cdc20 Ppp1cb Ppp2ca Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Wee1 Ppp2r1a Prc1 Cdk1 Bub1b Btrc Ninl Kiz Cdc25c Aurka Cenpe Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Cstf1 Bard1 Fancl Prkdc Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad51 Rad50 Pcna Fancd2 Ewsr1 Trp53 Topbp1 Xrcc6 Brca1 Ube2d3 Xrcc5 Atm Ube2l3 Cdk2 Rbbp8 Ccne1 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Rhoa Gna12 Gnaz Gnao1 Gnai2 Gnai1 S1pr5 Gnai3 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Src Stat5a Nras Pik3r1 Ngf Gab1 Grb2 Sos1 Hras Camk4 Ywhah Ntrk1 Ywhag Ywhae Pdpk1 Camk2a Ywhab Trpc3 Trpv1 Agap2 Akt1 Sfn Egr1 Bad Ccnd1 Foxo3 Plcg1 Gsk3b Creb1 Prkcd Ywhaz Pik3ca Kras Shc1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Jun Il18r1 Stat3 Il2ra Fos Il2 Ifng Pias2 Mapk8 Crebbp Stat4 Tgfb1 Il18 Il18rap Cd3e Mapk9 Cd4 H2-Eb1 Il13 Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Tbx21 Etv5 Irf1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Kif2c Ppp2r5d Smc4 Smc2 Birc5 Evi5 Ncaph Ppp1cc Cbx5 Npm1 Cdca8 Racgap1 Ncapd2 Septin1 Incenp Tacc1 Mylk Aurkb Des Nsun2 Pebp1 Klhl13 Rhoa Cul3 Vim Kif23 Kif20a Bub1 Sgo1 Aurka Psma3 Cenpa Stmn1 Ndc80 Rasa1 Klhl9 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Src Pik3r1 Nck1 Ptk2 Mapk1 Mapk3 Rhoa Bcar1 Ntn1 Rac1 Dock1 Elmo1 Fyn Yes1 Trio Dcc Map2k2 Map1b Wasl Map2k1 Dapk1 Pak1 Unc5b Camk2a Myo10 Unc5a Unc5c Agap2 Plcg1 Pik3ca S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gna13 S1pr4 Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Rhoa Gna12 Gnaz Gnao1 Gnai2 S1pr5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Mapk1 Pde3b Pik3cg Pik3r6 Map2k1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Cdkn1b Nras Ube2i Spi1 Ets1 Ptgs2 Myb Sin3a Pias3 Myc Adora2b Ccna1 Slc25a3 Birc3 Prtn3 Map3k7 Col1a2 Ets2 Clta Tfec Pim1 Iqgap1 Cdkn2a Rag2 Ppid Gata3 Atp2b1 Pax5 Zfpm1 Snd1 Maf Ncor1 Ptcra Kit Smarca2 Myod1 Mcm4 Cd34 Ep300 Bcl2 Lef1 Mat2a Cebpb Trim28 Cebpd Nlk Cebpa Elane Sp1 Csf1r Gstm2 Yeats4 Copa Wnt1 H2az1 Ppp3ca Kitlg Cbx4 Casp6 Anpep Mad1l1 Hspa8 Ca1 Hras Crebbp Zfhx3 Ski Cdk6 Lect2 Myf6 Tab2 Tab1 Hipk2 Ada Cdkn1a Ccnd1 Mpo Cd4 Hes1 Kras Gata1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Src Pxn Nras Rras Pik3r1 Nck1 Rap1a Ptk2 Mapk1 Grb2 Mapk3 Crk Hras Rac1 Ephb1 Ephb2 Wasl Map2k1 Ephb3 Map4k4 Pak1 Ephb4 Tf Efnb1 Efnb2 Efnb3 Rap1b Synj1 Dnm1 Itsn1 Rock1 Kalrn Efna5 Pik3ca Grb7 Kras Shc1 Rasa1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Mapk10 Src Mapk11 Pik3r1 Fasl Mapk8 Syk Map3k1 Pdpk1 Chuk Akt1 Birc3 Ikbkb Mapk9 Birc2 Mapk14 Ikbkg Map2k7 Map2k6 Cltc Cflar Faim2 Pik3cb Bid Casp8 Pik3ca Smpd1 Rfc1 Casp3 Ripk1 Btk Fas Fadd Ezr PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Nfkbia Bcl2 Smpd3 Ctsd Aifm1 Eif2ak2 Pawr Nsmaf Madd Asah1 Tnfrsf1a Bag4 Raf1 Tradd Mapk8 Cradd Mapk1 Pdgfa Traf2 Prkra Mapk3 Ksr1 Eif2a Map2k4 Sphk2 Bax Egf Igf1 Map2k2 Map3k1 Map2k1 Map4k4 Myc Akt1 Bad Tnf Birc3 Prkcd Nfkb1 Rb1 Bid Casp8 Smpd1 Ripk1 Prkcz Rela Fadd ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Lck Src Ppp2r5d Fkbp1a Ube2l3 Blk Pld1 Plcb2 Fyn Klk6 Yes1 Syk Pld2 Grk5 Ptk2b Th Tor1a Sncaip Slc6a3 Lyn Prkn Uchl1 Maob Stub1 Fgr Hck Bad Park7 Snca Prkcd ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Nfkbia Lck Src Pik3r1 Arrb2 Bcl3 Rel Ikbkb Mapk14 Nfkb1 Btrc Pik3ca Syk Rela RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Pkn1 Cdkn1b Jun Sh3gl2 Tln1 Pip5k1c Pip5k1b Vcl F2rl2 Fos Scai Mapk8 Itgb1 Rhoa Map2k4 Atf2 Pld1 Pld2 Ppp1r12a Rock2 Pip5k1a Rock1 Srf Ccn1 Slc9a1 Acta1 Mapk12 Map2k6 Pard6a Diaph1 Slc9a3 Rdx Cfl1 Msn Pten Cit Map2k3 Myl2 Limk1 Limk2 Prkcz Mrtfa Pkn2 Ezr SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Stat5a Stat3 Pik3r1 Rhoa Itga2b Bcar1 Blk Fyn Yes1 Itgb3 Lyn Akt1 Fgr Hck Cav1 Stat5b Shc1 Irs1 Lck Src Ins2 Prl Csf1r Ybx1 Prlr Egfr Cdh2 Fcgr3 Dok1 Csn2 Csf1 Insr Trpv6 Grb2 Txn Ptpn1 Pdgfrb Crk Csk Capn1 Pdgfb Spry2 Fer Lep Nox4 Egf Lat Lepr Socs3 Jak2 Pik3ca Tyk2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Src Prkaca Itga2 Mapk8 Sdc2 Mapk1 Csf2 Mapk3 Itgb1 Rhoa Hras Fgf15 Bax Cask Fn1 Mmp2 Kng2 Tnfrsf13b Ephb2 Sdcbp Cav2 Trappc4 Rack1 Epb41 Lama1 Lama3 Tgfb1 Prkcd Fgf23 Fgfr3 Fgfr4 Casp3 Nf1 Rasa1 Ezr RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Nras Ptpn7 Prkcb Braf Fos Map3k8 Elk1 Raf1 Mapk1 Prkca Mapk3 Hras Kras Map2k1 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Jun Mapk11 Fos Pou2f1 Ifng Mapk8 Mapk1 Mapk3 Junb Cul3 Atf2 Arg1 Mmp2 Bcl2l1 Th Plau Creb1 Mapk14 Atf3 Ep300 Bcl2 Ins2 Cbfb Prkca Brca1 Esr1 Cdk4 Socs3 Hrk Ccna2 Ccnd1 Hbb-bh1 Serpinb5 Kat5 Ache Il6 Mapk9 Macroh2a1 Ddit3 Col24a1 Hes1 Jdp2 Ruvbl2 Csrp2 Rb1 Jund Gadd45a Sele Dusp5 Tgfb2 Dusp1 Nos2 Pdgfra Nf1 Dusp10 Il23a Dusp8 Ppargc1a EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Efna2 Lck Efna3 Src Arhgef15 Crkl Ngef Epha1 Epha2 Epha3 Vav2 Epha4 Epha5 Epha6 Epha7 Cdk5 Epha8 Rhoa Crk Blk Vav3 Fyn Yes1 Lyn Fgr Pik3cg Hck Cbl Pik3r6 Plcg1 Rock1 Efna5 Efna1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Nfkbia Stat3 Prkaca Ranbp2 Hdac4 Ube2i Tnfrsf1a Ran Nr2c1 Smg5 Prmt5 Hdac3 Hdac5 Hdac7 Hdac6 Hdac9 Hdac8 Fkbp3 Sin3a Pparg Sin3b Chd3 Chd4 Sirt3 Sirt2 Sirt1 Hdac2 Smurf1 Wdr77 Sirt7 Gata2 Sirt6 Sirt5 Hdac1 Sirt4 Hdac11 Hdac10 Mta2 Tfcp2 Mbd3 Mbd2 Gatad2a Mxd1 Sap30 Gatad2b Sap18b Btrc Zfpm1 Ncor1 Max Ep300 Kat2b Rbbp4 Rbbp7 Crebbp Smad7 Ncor2 Tnf Nfkb1 Yy1 Rela Gata1 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Exoc1 Itga7 Nme1 Itga8 Exoc2 Dnm2 Pip5k1c Itga5 Spag9 Itga6 Avpr2 Itga9 Exoc7 Bin1 Ins2 Itga4 Ctnnd1 Itga1 Mapk8ip3 Itga2 Cpe Arf6 Itga10 Itga11 Itgav Itgb1 Pld1 Pld2 Ctnnb1 Klc1 Tshr Itga3 Cdh1 Asap2 Cltc Agtr1a Slc2a4 Adrb2 Scamp2 Acap1 Rala Exoc3 Exoc4 Ctnna1 Exoc5 Exoc6 Vamp3 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Cdkn1b Mapk10 Ep300 Csnk1a1 Csnk1g3 Ran Csnk1g1 Fasl Kat2b Mapk8 Bcl2l11 Csnk1g2 Zfand5 Skp2 Fbxo32 Ralb Mst1 Sod2 Crebbp Usp7 G6pc1 Rbl2 Cat Csnk1d Sgk1 Csnk1e Ywhah Cdk2 Sirt1 Ywhag Ywhae Ywhab Chuk Akt1 Sfn Foxo4 Plk1 Foxo3 Foxo1 Ikbkb Ywhaz Mapk9 Ctnnb1 Bcl6 Gadd45a Rala SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Gna15 Gna14 Abcc1 Gnaq Sphk1 Gna13 S1pr1 S1pr3 S1pr4 S1pr2 Sgpp1 Gnai1 Gnai3 Sphk2 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna11 Sgpl1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Cdkn1b Src Prkdc Prkaca Raf1 Bcl2l1 Ywhah Ywhag Ywhae Pdpk1 Cdkn1a Ywhab Chuk Akt1 Sfn Foxo4 Rictor Bad Mtor Map3k5 Akt3 Foxo3 Akt2 Foxo1 Gsk3b Casp9 Tbc1d4 Ywhaz Kpna1 Mapkap1 Gsk3a Mlst8 Slc2a4 Hsp90aa1 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Src Nme1 Pip5k1c Afdn Pik3r1 Vav2 Ctnnd1 Rap1a Itgae Arf6 Itgb7 Rhoa Crk Rac1 Akt1 Rap1b Ccnd1 Ctnnb1 Cdh1 Tiam1 Nckap1 Iqgap1 Klhl20 Ap1m1 Wasf2 Pik3ca Jup Cttn Tjp1 Dlg1 Ctnna1 Rapgef1 Cyfip2 Abi1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Dhh Hhip Ihh Lrp2 Gli2 Hhat Shh Pik3r1 Grk2 Akt1 Lrpap1 Ptch2 Smo Arrb2 Ptch1 Boc Gas1 Pthlh Cdon Pik3ca Tgfb2 Stil POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk3 Plk4 Plk2 Plk1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Jun Stat5a Stat3 Racgap1 Mapk8 Ncf1 Ncf2 Brk1 Arhgdia Noxa1 Bcar1 Map2k4 Baiap2 Atf2 Rac1 Iqgap3 Arpc1b Actr2 Plcb2 Actr3 Arhgap5 Pak2 Wasf1 Arpc3 Map3k1 Noxo1 Arpc2 Pak1 Cyba Abi2 Cybb Arpc5 Pip5k1a Arpc4 Map3k11 Nox1 Ctnnb1 Mapk14 Cdh1 Iqgap1 Cfl1 Map2k3 Ctnna1 Limk1 Pip5k1c Pip5k1b Crk Mapk9 Map2k7 Map2k6 Nckap1 Wasf2 Cyfip2 Abi1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Arr3 Cnga3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Rdh5 Gnb3 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Spata13 Arhgef9 Nme1 Fgd1 Git1 Ngef Dnmbp Mcf2 Arhgap17 Dock10 Dock11 Vav2 Ralbp1 Farp2 Racgap1 Dock6 Bcar3 Arhgef25 Apc Arhgap1 Itsn2 Arhgdia Vav3 Itsn1 Plcg1 Arhgef7 Mcf2l Arhgef6 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Ep300 Kdr Sp1 Adora2a Flt1 Epo Eif3e Ets1 Bhlhe40 Vegfa Hif1an Crebbp Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Pou5f1 Sirt1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn Arnt Elk1 Twist1 Serpine1 Efna1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Jun Mdm2 Pou2f1 Mapk8 Nr2c1 Hdac7 Map2k4 Sirt1 Gata2 Hdac1 Foxo1 Rel Mapk14 Hsp90aa1 Nr3c1 Smarca2 Pkn1 Src Ep300 Ar Ncoa2 Ncoa1 Cebpa Kat2b Crebbp Rack1 Hoxb13 Nr2c2 Kat7 Nr0b1 Egr1 Spdef Rxrb Rxra Gsk3b Smarce1 Kat5 Ehmt2 Rxrg Senp1 Carm1 Dnaja1 Zmiz2 Map2k6 Trim24 Appbp2 Pde9a Smarcc1 Tmprss2 Rchy1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Jun Crkl Pik3r1 Fos Elk1 Plcg1 Srf Cav1 Grb2 Itgav Sos1 Crk Pik3ca Cav3 Jak1 Shb Shf Pdgfra Rapgef1 Shc1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Ptn Src Mc4r Pomc Psen1 Agrp Egfr Fgf23 Fgfr3 Fgfr4 Fgf15 Cask Cttn Fyn Ncstn Aph1b Sdc3 Ncan SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Jun Mapk11 Cebpb Gdi1 Eif4ebp1 Pla2g4a Mitf Rab5a Elk4 Hspb1 Mapkapk3 Usf1 Mapkapk2 Krt8 Trp53 Eif4e Mapkapk5 Mef2a Rps6ka4 Esr1 Rps6ka5 Hbp1 Ptgs2 Mknk1 Atf2 Atf6 Mef2c Creb1 Slc9a1 Mapk14 Ddit3 Nos2 Ppargc1a ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Src Pxn Tln1 Git1 Prkaca Itga4 Arf6 Ptk2 Itgb1 Crk Bcar1 Spp1 Rac1 Prkar1a Dock1 Prkar1b Mdk Jaml Fn1 Jam2 Cd81 Ptk2b Ptpra Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Ywhaz Abi1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Dkk1 Ror2 Wnt1 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt7b Wnt3a Wnt7a Wnt2 Fzd10 Wnt3 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd7 Fzd6 Kremen1 Fzd9 Rspo1 Fzd8 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Fosl1 Cdkn1b Jun Fos Il2 Il4 Ifng Nfatc1 Csf2 Junb Ets1 Nfatc3 Myb Nfatc2 Atf2 Il10 Th Mmp9 Plau Gata2 Myc Tgfb1 Creb1 Ccn1 Ctnnb1 Col1a2 Acta1 Cdkn2a Cdk1 Pten Atf3 Maf Nr3c1 Ep300 Dmp1 Gja1 Edn1 Elf1 Penk Trip6 Il5 Dmtf1 Sp1 Mt2 Nts Mafg Crtc1 Bag1 Fosb Bcl2l11 Tcf7l2 Cops5 Cbfb Trp53 Fabp4 Timp1 Agt Esr1 Nppa Fosl2 H2-Q10 Egr1 Ccnd1 Hif1a Il6 Ccl12 Mmp1a Jund Dusp1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Stat5a Lyn Ptpn11 Pik3r1 Il5 Grb2 Stat5b Pim1 Jak2 Csf2rb2 Pik3ca Il5ra Cish Sdcbp INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Jun Pxn Ilk Rac1 Myl12a Ilkap Ruvbl1 Rhog Ppp1r14a Ppp1r12a Ppp1r14c Ppp1r14b Elmo2 Nck2 Tns1 Git2 Parvg Tacc3 Akt1 Snai1 Lims2 Rictor Zeb1 Ccnd1 Actn1 Parvb Gsk3b Zyx Creb1 Cdc37 Parva Ctnnb1 Ckap5 Parp1 Ruvbl2 Diaph1 Iqgap1 Aurka Hsp90aa1 Arhgef7 Arhgef6 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Gja1 Pip5k1c Ptpn11 Pik3r1 Ctnnd1 Cdh2 Mapk8 Ptpn1 Rhoa Rac1 Fer Gsn Lrp5 Plcg1 Rock1 Ctnnb1 Daglb Camk2g Mapre1 Dctn1 Gap43 Kif5b Cnr1 Fgfr1 Pik3ca Jup Gria2 Cttn Dagla Axin1 Myl2 Ctnna1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Thrb Thra Bcl2 Nr1h4 Nr1h3 Nr1h2 Ppard Ncoa1 Ppara Abca1 Srebf1 Nr4a1 Vdr Pparg Ncor2 Tgfb1 Rxrb Rxra Tnf Rxrg Fam120b Rara Rarb Med1 Rarg P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Trp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Jun Stat5a Ctsd Hdac4 Col18a1 Mpg Nrip1 Sra1 Ube2m Apbb1 Ebag9 Safb Phb2 Pdia2 Anp32a Ddx17 Ap1b1 Ddx54 Pou4f1 Lcor Pou4f2 Nr0b2 Cd82 Trim59 Dscam Pgr Axin2 Ncoa7 Atp5pf Chuk Myc C3 Hdac1 Mta1 Greb1 Hsf2 Ncoa3 Xbp1 Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Uba3 Nedd8 Ncor1 Ep300 Cebpb Ncoa2 Ncoa1 Lmo4 Prl Pcna Brca1 Esr1 Smad4 Ncor2 Nr0b1 Ccnd1 Med1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Stat5a Itga5 Pik3r1 Mapk8 Mapk1 Mapk3 Itgb1 Ets1 Rac1 Fyn Mmp2 Pld2 Dok2 Pak1 Akt1 Foxo1 Mapk14 Grb14 Fgf2 Angpt2 Stat5b Angpt4 Agtr1a F2 Fes Elf2 Tnip2 Plg Bmx Grb7 Shc1 Rasa1 Pxn Elf1 Ptpn11 Angpt1 Nck1 Ptk2 Grb2 Crk Nos3 Fn1 Tek Cdkn1a Elk1 Tnf Nfkb1 Pik3ca Rela DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Fosl1 Jun Nras Il2ra Prkcb Fos Prkce Il2 Ifng Fasl Mapk8 Mapk1 Nfatc1 Mapk3 Junb Nfatc3 Nfatc2 Il2rg Tnfrsf4 Il2rb Prkcq Tnfrsf9 Ifna16 B2m Gzmb Ifnar1 Eomes Ifnar2 Egr4 Cd8a Cd8b1 Tnfrsf18 Raf1 Prkca Hras H2-Q10 Map2k2 Map2k1 Ptpn7 Stat4 Braf Elk1 Egr1 Cd3e Tnf Mapk9 Cd3g Cd247 Prf1 Cd3d Kras SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Jun Itga5 Rras Pik3r1 Mapk8 Mapk1 Itgav Itgb1 Ets1 Rhoa Bcar1 Map2k4 Rac1 Dock1 Elmo1 Fyn Yes1 Wasl Pak1 Rock2 Acta1 Itgb5 Bmx Grb7 Arhgef7 Rasa1 Src Tln1 Pxn Vcl Arhgef11 Asap1 Nck1 Rap1a Arhgef28 Mapk8ip3 Sh3gl1 Arhgap26 Capn2 Ptk2 Raf1 Klf8 Ptpn21 Grb2 Sos1 Crk Arhgap35 Map2k1 Nck2 Git2 Braf Rap1b Actn1 Ccnd1 Plcg1 Mapk9 Pik3ca Rapgef1 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Lamb3 Lama2 Lamb1 Lama5 Lama1 Lamc2 Lama3 Itgb4 Itga6 Lamb2 Lamc1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Fancl Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad50 Fancd2 Topbp1 Brca1 H2ax Ube2t Blm Atm Chek1 Rad9a Top3a Wdr48 Fanci Fancm Usp1 Fancb Palb2 Rfc5 Rfc3 Faap100 Rfc2 Rpa1 Rpa2 Hus1 Rad17 Atrip Brip1 Cenps Brca2 Fbxw11 Xrcc3 Rad1 Faap24 Fan1 Hes1 Btrc VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Krt14 Wwp1 Rab38 Krt5 Nrg1 Cebpd Mre11a Adrm1 Il1a Axl Fbxw7 Perp Trp63 Top2a Mdm2 Vdr Hbp1 Fosl2 Atm Ada Rack1 Sfn Col5a1 Brca2 Gsk3b Yap1 Dlx5 Hes1 Bdkrb2 Itga3 Ppp2r5a Hells Igfbp3 Cdkn2a Itch Sec14l2 Stxbp4 T Fasn Tcf7l1 Pou2f2 Notch1 Ccnb2 Gpx2 Rrad CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Srebf1 Madd App Arhgdib Tnfrsf1a Slk Tradd Cfl2 Xiap Cradd Sptan1 Traf2 Lmna Apaf1 Gas2 Top1 Tfap2a Vim Numa1 Lmnb1 Bax Lmnb2 Pidd1 Casp7 Gsn Krt18 Casp4 Satb1 Casp2 Map3k1 Casp1 Diablo Dffa Dffb Birc3 Acta1 Limk1 Gzmb Bcl2 Ptk2 Casp6 Tnf Casp9 Birc2 Parp1 Prf1 Bid Casp8 Casp3 Ripk1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Spata13 Rasgrf1 Ngef Mcf2 Arhgap17 Vav2 Ralbp1 Racgap1 Dock6 Arhgef25 Arhgap1 Sos1 Arhgdia Rac1 Dock1 Elmo1 Vav3 Trio Tiam2 Arhgef2 Dock2 Abr Eps8 Def6 Rap1gds1 Prex1 Vav1 Bcr Kalrn Arhgap9 Tiam1 Arhgef7 Abi1 Arhgef6 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Tln1 Itgam Rap1a Rhoa Mst1 Itgb2 Jam2 Mmp2 Mmp9 Plau Myh2 Thy1 Rap1b Hck Selp Rock1 Tnf Lrp1 Il6 Selplg Ccn2 Jam3 Plat Ager Nfkb1 Icam1 Plaur Mst1r Apob Plg ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Nme1 Pip5k1a Arf6 Kalrn Mapk1 Tiam1 Mapk3 Rhoa Plaur Rac1 Arf1 Pld1 Rab11fip3 Rab11a Pld2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Jun Prkcb Pik3r1 Pla2g4a Fos Mapk8 Mapk1 Mapk3 Map2k4 Nfatc2 Fyn Syk Pld2 Pak2 Map3k1 Lyn Chuk Inpp5d Akt1 Cbl Vav1 Itk Plpp1 Fcer1a Klrg1 Gab2 Shc1 Hcls1 Rasa1 Cblb Wipf1 Fcer1g Pxn Lat2 Lcp2 Ptpn13 Ptpn11 Pla2g1b Ms4a2 Fcgr2b Ptk2 Dok1 Raf1 Grb2 Sos1 Hras Fer Lat Map2k2 Map2k1 Sphk1 S1pr1 Plcg1 Ikbkb Ikbkg Map2k7 Nfkb1 Pik3ca Dusp1 Btk Rela S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Src Cxcr4 Gnai1 Gnai3 Mapk1 Flt1 Mapk3 Pdgfrb Rhoa Vegfa Pdgfb Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Gna13 S1pr3 Akt1 Akt3 Jak2 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Vcam1 Pxn Itgb7 Itgb1 Rhoa Itga4 Madcam1 Ptk2 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Crkl Rasgrf1 Nras Stat3 Pik3r1 Mapk1 Mapk3 Rhoa Rac1 Dock1 Elmo1 Mcf2l Gab2 Shc1 Rasa1 Bdnf Ptpn11 Rap1a Ngf Gab1 Frs3 Matk Frs2 Sqstm1 Faim Prkci Maged1 Ngfr Dnaja3 Ntf4 Grb2 Shc3 Ntf3 Sos1 Shc2 Crk Gipc1 Rgs19 Hras Nedd4l Abl1 Arhgap32 Rit1 Rit2 Ehd4 Ntrk2 Rhog Ntrk1 Map2k1 Ntrk3 Rap1b Dnm1 Ccnd1 Plcg1 Tiam1 Pik3ca Rapgef1 Kras Prkcz CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Lck Src Nras Pik3r1 Rap1a Arf6 Rhoa Hras Rac1 Blk Fyn Lat Yes1 Syk Cyth2 Sgk1 Zap70 Cyth3 Cyth1 Dapp1 Pdpk1 Inppl1 Lyn Plekha2 Plekha1 Plcg2 Inpp5d Blnk Arap3 Fgr Adap1 Pik3cg Hck Arf5 Pik3r6 Foxo3 Plcg1 Pik3cb Arf1 Pik3ca Pten Itk Hsp90aa1 Btk Kras ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Wwp1 Stat5a Nrg1 Pik3r1 Prl Prlr Mdm2 Mapk1 Grb2 Mapk3 Fyn Tab2 Wwox Erbb2 Erbb4 Lrig1 Adam17 Hbegf Ereg Yap1 Nrg2 Btc Cbfa2t3 Stat5b Nrg4 Nrg3 Dlg4 Itch Pik3cb Jak2 Grin2b Pik3ca Ncor1 Shc1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Stat5a Nras Stat3 Stat1 Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk1 Grb2 Csf2 Mapk3 Sos1 Hras Csf2rb2 Cish Syk Map2k2 Prkacb Map2k1 Lyn Inpp5d Ikbkb Ywhaz Ccl12 Pim1 Stat5b Jak2 Csf2ra Pik3ca Osm Irf8 Kras Shc1 Gab2 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Pkn1 Mapk12 Map2k6 Mapk13 Map2k3 Ccnd1 Eef2k Map3k20 Snta1 Stmn1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Aqp5 Kifc3 Mgat3 Aqp3 Git1 Pip5k1c Nectin2 Lpp Afdn Vcl Myo6 Epha2 Stx4 Nck1 Plekha7 Ctnnd1 Camsap3 Egfr Arf6 Rhoa Egf Igf1 Igf1r Hgf Actn1 Rock1 Zyx Ctnnb1 Cdh1 Diaph1 Nckap1 Met Exoc3 Exoc4 Myl2 Ctnna1 Cyfip2 Lima1 Abi1 Vasp Efna1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Mapk11 Prkcb Prkaca Pik3r1 Myof Cdh5 Ptprj Camkk2 Akap1 Mapkapk2 Sh2d2a Mapk1 Hsp90ab1 Hgs Itgav Ptpn2 Mapk3 Vtn Rhoa Fyn Pak2 Ptk2b Itgb3 Ptpn6 Akt1 Cbl Fbxw11 Cav1 Ctnnb1 Mapk14 Iqgap1 Fes Arf1 Map2k3 Hsp90aa1 Ctnna1 Src Pxn Dnm2 Grb10 Vcl Kdr Ptpn11 Nck1 Gab1 Ptk2 Raf1 Grb2 Flt1 Prkca Vegfa Nos3 Map2k2 Map2k1 Pdpk1 Nck2 Braf Plcg1 Rock1 Prkcd Map2k6 Pik3ca Shb VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Fosl1 Birc5 Npm1 Eif4e Riox2 Peg10 Bmi1 Ndufaf2 Bax Bcat1 Ddx18 Trrap Shmt1 Taf12 Rcc1 Hspd1 Mmp9 Prdx3 Supt3 Cad Nme2 Taf4b Myc Mtdh Actl6a Mta1 Ldha Cdc25a Serpini1 Odc1 Taf9 Eif4g1 Gpam Rpl11 Id2 EG433182 Eif2s1 Supt7l Pfkm Pim1 Lin28b Myct1 Ccnd2 Tfrc Polr3d Hmga1 Pdcd10 Hspa4 Ireb2 Eif4a1 Hsp90aa1 Ubtf E2f3 Huwe1 Tert Tk1 Max Nme1 Ep300 Nbn Kat2a Trp53 Crebbp Smad3 Smad4 Slc2a1 Ruvbl1 Cdk4 Snai1 Kat5 Ruvbl2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Dusp16 Lck Src Traf6 Mapk11 Pak3 Prkg1 Map3k3 Ccm2 Map3k12 Ralb Map2k4 Rac1 Blk Fyn Yes1 Tab1 Pak2 Pak1 Lyn Fgr Hck Mapk14 Map2k6 Rala Dusp1 Map2k3 Ripk1 Dusp10 Dusp8 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Stat5a Crkl Stat3 Stat1 Pik3r1 Mitf Mapk8 Socs1 Mapk3 Lyn Ptpn6 Akt1 Cbl Foxo3 Vav1 Pten Kit Shc1 Bcl2 Grb10 Ptpn11 Stap1 Ptpro Spred1 Gab1 Spred2 Matk Epor Grap2 Dok1 Raf1 Pik3c2b Snai2 Sh2b2 Kitlg Sh2b3 Map4k1 Grb2 Tec Epo Sos1 Hras Crebbp Fer Map2k2 Map2k1 Pdpk1 Bad Gsk3b Jak2 Pik3ca GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Bmp4 Fgf7 Gpc3 Shh Furin Ptch1 Mapk9 Mapk8 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Src Pxn Itga9 Csf2 Itgb1 Bcar1 Vegfa Spp1 Tnc Rac1 Adam12 Adam15 Sat1 Vegfd Fn1 Vegfc Tgm2 Paox Adam2 F13a1 Adam8 Vcam1 Kcnj15 Csf2ra Nos2 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Pnkp Prkdc Polm Nhej1 Dntt Aptx Dclre1c Lig4 Aplf Xrcc4 Poll Xrcc6 Xrcc5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Jun Crkl Pik3r1 Eif4ebp1 Rab5a Ptprj Mapk8 Mapk1 Eif4e Hgs Ptpn2 Mapk3 Ets1 Rhoa Bcar1 Map2k4 Rac1 Pak2 Map3k1 Wasl Pak1 Inpp5d Akt1 Cbl Mtor Ctnnb1 Cdh1 Pard6a Ctnna1 Gab2 Shc1 Sh3gl2 Src Pxn Ptpn11 F2rl2 Nck1 Rap1a Gab1 Arf6 Ptk2 Raf1 Prkci Apc Grb2 Sos1 Ptpn1 Crk Hras Map2k2 Map2k1 Pdpk1 Inppl1 Nck2 Rap1b Snai1 Egr1 Hgf Bad Plcg1 Akt2 Rptor Kpnb1 Numb Sh3kbp1 Eps15 Mlst8 Ranbp9 Rin2 Arhgef4 Met Deptor Pak4 Akt1s1 Pik3ca Muc20 Ranbp10 Rapgef1 Prkcz EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Src Tln1 Pip5k1c Nras Stat3 Stat1 Ptpn11 Pik3r1 Nck1 Gab1 Egfr Ptk2 Gnai1 Gnai3 Mapk1 Grb2 Mapk3 Ptpn1 Sos1 Hras Gsn Egf Wasl Pak1 Nck2 Ptpn6 Plcg1 Pik3cb Pik3ca Kras Shc1 Rasa1 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Snx2 Pkn1 Gng2 Snx1 Arrb1 Dnm2 Akap13 Prkcg Prkcb Gnb1 Pik3r1 F2rl2 Gnai1 Gnai3 Prkca Arhgdia Rhoa Gna12 Gnaz Nos3 Gnao1 Plcb2 Gnai2 Gna11 Gna15 Gna14 Rock2 Gnaq Gna13 Dnm1 Rock1 Zyx Prkcd F2 Pik3ca Plcb3 F2r Myl2 Arhgef1 Plcb1 Trpc6 Vasp Grk3 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Dnm2 Itga5 Cxcl12 Sdc4 Fgf6 Cxcr4 Nudt16l1 Tfpi Ptk2 Prkca Itgb1 Gipc1 Rhoa Tnc Rac1 Adam12 Mdk Ccl5 Fn1 Tnfrsf13b Mmp9 Sdcbp Lama1 Lama3 Thbs1 Actn1 Prkcd Fgf2 F2 Fgfr1 Plg Fzd7 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Mdm2 Smyd2 Cse1l Kat8 Mapk8 Fbxo11 Ppp1r13l Prmt5 Kmt5a Dyrk2 Ptpa Rpl23 Ube2d1 Ccng1 Chek2 Setd7 Cop1 Ttc5 Pin1 Mdm4 E4f1 Ppm1d Daxx Akt1 Ppp2ca Rpl11 Mapk14 Nedd8 Cdkn2a Huwe1 Ep300 Trim28 Csnk1a1 Csnk1g3 Csnk1g1 Kat2b Csnk1g2 Trp53 Skp2 Crebbp Atm Usp7 Chek1 Abl1 Csnk1d Hipk2 Csnk1e Cdk2 Ccna2 Gsk3b Kat5 Prkcd Mapk9 Rchy1 Yy1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Fosl1 Cblb Jun E2f1 Egr4 Il2ra Il5 Fos Batf3 Il2 Il4 Pou2f1 Ifng Fasl Cd40lg Nfatc1 Csf2 Ptpn1 Junb Nfatc3 Ptgs2 Nfatc2 Pparg Cdk4 Rnf128 Ctla4 Irf4 Ptprk Dgka Slc3a2 Egr3 Ikzf1 Foxp3 Egr1 Tnf Egr2 Itch Gata3 Tbx21 Casp3 Prkcq Maf E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Cdh1 Jup Ctnnb1 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Gna15 Irs1 Jun Gna14 Pak1 Gnaq Gna13 Fos S1pr2 Elk1 Cdh5 Gnai1 Gnai3 Mapk14 Mapk8 Mapk1 Mapk3 Rhoa Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Src Gng2 Ar Gnb1 Pik3r1 Fos Ptk2 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Rac1 Gnaz Gnao1 Plcb2 Gnai2 Map2k2 Map2k1 Plcg2 Akt1 Gnrh1 Shbg Pelp1 Plcg1 Creb1 Pik3ca Plcb3 Plcb1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Plk3 Trp53 Chek2 Cdc25c Ccne1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Fosl1 Ep300 Jun Gja1 Dmtf1 Sp1 Nfatc1 Junb Nfatc3 Itgb4 Fosl2 Nfatc2 Nos3 Mmp2 Mmp9 Plau Lama3 Ccna2 Ccnd1 Hmox1 Txlng Usf2 Il6 Lif Col1a2 Dcn Ccl12 Thbd Mgp Mmp1a Atf4 Jund Cdkn2a Plaur ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Trim28 Mre11a Nbn Mdm2 Rad50 Fancd2 Brca1 H2ax Blm Atm Chek2 Abl1 Rad9a Top3a Cop1 Ctbp1 Ywhab Rad17 Cdc25a Dclre1c Xrcc4 Kat5 Mdc1 Terf2 Smc3 Ube2n Abraxas1 Bid Rbbp8 Uimc1 Trp53bp1 Smc1a Cdc25c HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Nfkbia Bcl2 Tnfrsf1a Bag4 Fasl Tradd Mapk8 Cradd Traf2 Casp6 Apaf1 Casp7 Casp2 Daxx Chuk Map3k14 Map3k5 Tnf Birc3 Casp9 Map2k7 Cd247 Nfkb1 Cflar Bid Casp8 Casp3 Traf1 Ripk1 Fas Rela Fadd ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Sftpa1 Myd88 Ly96 Tlr1 Chuk Vcan Cd14 Irak4 Ticam1 Tlr6 Tirap Tlr4 S100a9 S100a8 Tlr3 Tlr2 Ikbkb Ikbkg Rhoa Irak2 Irak1 Saa3 Hspd1 Bgn IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Stat5a Il1b Stat3 Stat1 Il2 Ifng Ebi3 Il6st Il12a Il12rb2 Il27 Il27ra Stat2 Jak1 Stat4 Tgfb1 Il12b Il18 Tnf Il6 Jak2 Il12rb1 Gata3 Tyk2 Tbx21 Il17a P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Mapk10 Psen1 Pik3r1 App Mapk8 Xiap Apaf1 Arhgdia Rhoa Rac1 Prkacb Diablo Chuk Akt1 Birc3 Plg Irak1 Shc1 Traf6 Myd88 E2f1 Bdnf Ngf Sqstm1 Prkci Bcl2l11 Maged1 Ngfr Trp53 Ntf4 Ntf3 Casp6 Rhoc Rhob Lingo1 Furin Mmp3 Omg Mag Mageh1 Smpd2 Bex3 Bex1 Nsmce3 Ntrk1 Rtn4 Ywhae Ripk2 Mmp7 Ndn Prdm4 Sort1 Zfp369 Bad Adam17 Casp9 Ikbkb Mapk9 Birc2 Ikbkg Pik3ca Casp3 Ncstn Aph1b Prkcz CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Pip5k1b Nkd2 Ranbp3 Dvl1 Lrp6 Klhl12 Dvl2 Dvl3 Pi4k2a Gsk3b Cav1 Csnk1g1 Apc Wnt3a Ctnnb1 Gsk3a Ppp2r5a Cul3 Fzd5 Axin1 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Src Jun Stat1 Ptpn11 Pik3r1 Fos Ctnnd1 Gab1 Frs2 Cdh2 Runx2 Sdc2 Mapk1 Grb2 Mapk3 Sos1 Fgf15 Spp1 Spry2 Ptk2b Mmp9 Plau Pdpk1 Camk2a Akt1 Cbl Plcg1 Klb Il17rd Fgf1 Ncam1 Fgf23 Fgfr3 Ssh1 Fgfr4 Fgfr2 Cdh1 Rps6ka1 Stat5b Plaur Pak4 Fgfr1 Pik3ca Cttn Shc1 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Smad1 Acvr1 Tlx2 Smad9 Amhr2 Fkbp1a Amh Bmp7 Smad5 Smad4 Bmpr2 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Cmtm2b Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Pawr Snurf Appl1 Ube2i Hnrnpa1 Ncoa6 Pias1 Ccnd3 Nrip1 Kdm3a Tgfb1i1 Tcf4 Vav3 Gsn Pias3 Ptk2b Tgif1 Pias4 Akt1 Pelp1 Srf Ctnnb1 Uba3 Cdkn2a Prkdc Ar Ncoa2 Xrcc6 Brca1 Xrcc5 Cdk6 Ccnd1 Carm1 Ranbp9 Hip1 Lats2 Tmprss2 Fhl2 Casp8 Kdm4c Kdm1a Znf318 Prdx1 Fkbp4 Patz1 Med1 Rps6ka3 Mak E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Src Pip5k1a Pik3r1 Akt1 Ctnnd1 Plcg1 Egfr Akt2 Zyx Ctnnb1 Casr Ajuba Cdh1 Rhoa Rac1 Pik3ca Jup Fyn Ctnna1 Vasp IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Jun Mapk11 Cebpb Stat3 Cebpd Stat1 Ptpn11 Pik3r1 Fos Mitf Lmo4 Gab1 Pias1 Il6st Grb2 Crp Timp1 Hsp90b1 Junb Sos1 Lbp Mcl1 Map2k4 Ptpre Rac1 Fgg Tnfsf11 Jak1 A2m Pias3 Bcl2l1 Il6ra Myc Socs3 Akt1 Hck Vav1 Foxo1 Prkcd Il6 Mapk14 Map2k6 Jak2 Pik3ca Tyk2 Irf1 Gab2 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha2 Epha3 Epha4 Epha5 Epha6 Epha7 Efna5 Epha8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Nbn Rad51 Mdm2 Fancd2 Topbp1 Chek1 Rad9a Mcm7 Smarcal1 Ppp2r2b Timeless Cep164 Cdk2 Cdc6 Rfc5 Tipin Rfc3 Mcm2 Ywhab Rfc2 Rpa1 Rpa2 Hus1 Rad17 Cdc25a Ppp2ca Atrip Plk1 Ccna2 Clspn Brca2 Fbxw11 Rad1 Ywhaz Ppp2r1a Btrc Cdc25c DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Axin2 Cul1 Skp1 Dvl1 Lrp6 Dvl2 Dvl3 Csnk1a1 Gsk3b Apc Wnt3a Ctnnb1 Gsk3a Fzd5 Btrc Axin1 Csnk1d Csnk1e IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Irs1 Pxn Irs2 Crkl Grb10 Ptpn11 Pik3r1 Ptk2 Raf1 Grb2 Ptpn1 Sos1 Crk Bcar1 Hras Igf1 Ywhae Pdpk1 Rack1 Nck2 Igf1r Prkd1 Akt1 Bad Prkcd Ywhaz Pik3ca Shc1 Prkcz CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Pgr Vcam1 Il1b Nlrp1a Antxr2 Antxr1 Il18 Tnf Mapk1 Map2k7 Map2k6 Mapk3 Map2k4 Map2k3 Map2k2 Casp1 Map2k1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Gnb1 Gngt1 Slc24a1 Rdh12 Pde6a Pde6b Rgs9bp Gnat1 Cnga1 Pde6g Rho Sag Grk1 Gucy2e Rpe65 Rdh5 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Ep300 Birc5 Fos Sp1 Gas1 Aurkb Skp2 Nfatc3 Esr1 Crebbp Chek2 Mmp2 Cdk4 Cdk2 Map2k1 Myc Plk1 Ccna2 Ccnd1 Brca2 Cenpb Gsk3a Hspa1a Onecut1 Nek2 Rb1 Cdkn2a Foxm1 Cdk1 Cks1b Tgfa Lama4 Xrcc1 Etv5 Cenpf Cenpa Ccnb2 Cdc25b Ccne1 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Gng2 Arrb1 Prkcg Prkcb Gnb1 Grk2 Prkce Rab5a Prkca Pld1 Plcb2 Gnai2 Gna15 Gna14 Pdpk1 Lyn Akt1 Fgr Pik3cg Hck Cbl Dnm1 Pik3r6 Arrb2 Plcb3 Cxcr1 Plcb1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Fga F10 Tgfbi Itgax F11r Icam4 Icam2 Itgam Itgal Fcgr3 Cd40lg Itgad Itgb2 Fgg Kng2 Plau Vcam1 C3 Thy1 Ccn1 Jam3 Plat Icam1 Plaur Spon2 Proc Gp1ba Fgb INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Gm14226 Gys1 Stx4 Ppp1cc Ins2 Lnpep Rhoq Trip10 Ppp1r3a Vamp2 Prkci Insr Ywhah Ywhag Ywhae Ywhab Akt1 Sfn Akt2 Gsk3b Tbc1d4 Ywhaz Slc2a4 Stxbp4 Prkcz PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Mapk10 Stat5a Stat3 Stat1 Pik3r1 Eif2ak2 Ptprj Mapk8 Mapk1 Itgav Ptpn2 Mapk3 Brk1 Ksr1 Arhgdia Rhoa Bcar1 Map2k4 Baiap2 Rac1 Arpc1b Blk Actr2 Actr3 Ppp2r2b Arpc3 Arpc2 Itgb3 Pak1 Lyn Arpc5 Arpc4 Fgr Ppp2ca Hck Srf Ppp2r1a Pten Shc1 Rasa1 Src Grb10 Ptpn11 Nck1 Rap1a Gab1 Sla Dok1 Arap1 Rab4a Usp6nl Grb2 Tagln Prkca Myocd Dock4 Sos1 Ptpn1 Actn4 Crk Csk Nherf2 Hras Nherf1 Sipa1 Ywhah Ywhag Ywhae Ywhab Braf Sfn Elk1 Plcg1 Prkcd Ywhaz Mapk9 Jund Kras Jun Nras Prkce Pla2g4a Fos Vav2 Rab5a Fyn Yes1 Pin1 Wasl Myc Eps8 Pik3cg Pik3r6 Cbl Lrp1 Stat5b Iqgap1 Lck Dnm2 Afdn Raf1 Pdgfrb Pdgfb Abl1 Pag1 Arhgap35 Map2k2 Map2k1 Nck2 Sphk1 S1pr1 Rap1b Map2k7 Nckap1 Pik3cb Jak2 Wasf2 Pik3ca Cttn Rapgef1 Cyfip2 Rps6ka3 Abi1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Src Tln1 F11r Pip5k1c Nectin2 Afdn Pik3r1 Vav2 Rap1a Farp2 Ptk2 Itgav Pdgfrb Crk Pdgfb Rac1 Nectin1 Nectin3 Ptprm Cldn1 Itgb3 Rap1b Ctnnb1 Cdh1 Iqgap1 Pik3ca Ctnna1 Rapgef1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Nfkbia Jun Pik3r1 Fos Vav2 Mapk8 Mapk1 Nfatc1 Mapk3 Ets1 Rac1 Syk Map3k1 Lyn Chuk Inpp5d Ptpn6 Akt1 Map3k7 Mapk14 Pten Shc1 Rasa1 Traf6 Fcgr2b Dok1 Raf1 Ppp3ca Map4k1 Grb2 Sos1 Csk Hras Pag1 Cd72 Cd22 Malt1 Card11 Map2k1 Dapp1 Cd79a Pdpk1 Cd79b Ibtk Bcl10 Plcg2 Ptprc Blnk Nfkbib Ppp3cc Ppp3cb Elk1 Cd19 Bcl2a1d Sh3bp5 Ikbkb Ikbkg Camk2g Nfkb1 Pik3ca Pou2f2 Btk Rela REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Cdkn1b Arhgef15 Ngef Akap13 Mcf2 Arhgef11 Vav2 Arhgef28 Arhgdib Arhgef25 Arap1 Arhgdia Rhoa Arhgap35 Vav3 Arhgap5 Trio Ect2 Arhgef2 Abr Arap3 Def6 Srgap1 Vav1 Arhgef3 Bcr Ophn1 Arhgap9 Arhgef17 Arhgdig Arhgef10 Arhgef12 Myo9b Arhgef18 Plekhg6 Arhgap6 Net1 Farp1 Arhgap4 Arhgef10l Dlc1 Arhgap8 Arhgef1 Mcf2l EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Syt1 Stx1a Stxbp1 Vamp2 Unc13b Chrna1 Snap25 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Mark2 Adam10 Neurl1a Notch4 Notch2 Notch3 Fbxw7 Dtx1 Dll1 Dll3 Il4 Mycbp Dll4 Mfap5 Jag2 Jag1 Mfap2 Dlk1 Mib1 Cntn1 Cntn6 Dner Lnx1 Cul1 Ctbp1 Skp1 Myc Hdac1 Cbl EG433182 Gata3 Btrc Rab11a Ncor1 Ptcra Ep300 Skp2 Furin Adam12 Cdkn1a Spen Ncor2 Dnm1 Ccnd1 Maml1 Maml2 Numb Eps15 Itch Rbbp8 Kdm1a Rbpj Yy1 Notch1 Ncstn Aph1b GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Lck Stat5a Bcl2 Il2ra Elf1 Ptpn11 Pik3r1 Sp1 Il2 Il4 Ccnd3 Fasl Grb2 Sos1 Jak3 Cdk6 Jak1 Bcl2l1 Lta Myc Foxp3 Ccna2 Il2rg Stat5b Prf1 Ccnd2 Pik3ca Il2rb Shc1 Gab2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Mapk10 Src Jun Nrg1 Nras Stat3 Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk8 Mapk1 Grb2 Mapk3 Sos1 Hras Rac1 Erbb3 Nfatc4 Nf2 Chrne Usp8 Rnf41 Map2k2 Dock7 Map2k1 Akt1 Ppp3cb Bad Erbb2 Mtor Mapk9 Nrg2 Pik3cb Jak2 Pik3ca Kras Shc1 Chrna1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Gng2 Arrb1 Prkcg Prkcb Gnb1 Rab5a Prkca Elmo1 Plcb2 Gnai2 Pld2 Rab7 Gna15 Cxcr2 Gna14 Pdpk1 Rac2 Lyn Dock2 Akt1 Fgr Pik3cg Ppp2ca Hck Cbl Dnm1 Pik3r6 Arrb2 Ppp2r1a Plcb3 Rab11a Plcb1 Vasp FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc2 Sdc1 Sdc4 Sdc3 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Fga Tgfbi F11r Kdr Sdc4 Itgav Lamb1 Vtn Pdgfrb Itga2b Vegfa Pdgfb Spp1 Tnc Fgg Fn1 Lamc1 Plau Itgb3 Col1a1 Sphk1 L1cam Col4a3 Thbs1 Pecam1 Col4a4 Thy1 Cd47 Edil3 Ibsp Col4a1 Fbn1 Col4a5 Ccn1 Col4a6 Col1a2 Sdc1 Plaur Lama4 Tgfbr2 Fgb THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Jun Stat5a Mapk11 Nras Stat3 Il2ra Prkcb Stat1 Pik3r1 Fos Prkce Il2 Ifng Mapkapk2 Mapk8 Socs1 Mapk1 Mapk3 Rhoa Jak3 Jak1 Fyn Syk Ptk2b Dok2 Myc Socs2 Stam2 Ikzf3 Stam Mapk14 Il2rg Stat5b Il2rb Gab2 Shc1 Rasa1 Irs1 Lck Bcl2 Irs2 Ptpn11 Raf1 Grb2 Sos1 Hras Cish Map2k2 Cdk2 Map2k1 Socs3 Mapk9 Pik3ca Kras GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc3 Gpc2 Gpc1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Npas2 Nr1d1 Nono Cry1 Cry2 Bhlhe40 Clock Bmal1 Chek1 Per1 Wdr5 Timeless Csnk1e IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Stat5a Il18r1 Il1b Stat3 Il2ra Stat1 Fos Il2 Il4 Ifng Fasl Socs1 Stat6 Sphk2 Atf2 Rab7 Mtor Mapk14 Il2rg Nfkb2 Il2rb Ccr5 Map2k3 Relb Gadd45g Gzma B2m Gadd45b Gzmb Hlx Lck Ccl4 Eomes Il1r1 Cd8a Cd8b1 Il12a Il12rb2 H2-Q10 Ripk2 Stat4 Il12b Il18 Il18rap Cd3e Cd4 H2-Eb1 Cd3g Map2k6 Cd247 Nfkb1 Cd3d Jak2 Il12rb1 Tyk2 Tbx21 Nos2 Rela BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Plau Vcam1 Edil3 Itga4 Madcam1 Fbn1 Ccn1 Itgb8 Itgb6 Itgav Itgb7 Vtn Itgb5 Sdc1 Plaur Tgfbr1 Fn1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Cdkn1b Pik3r1 Mapk1 Ilk Itgav Mapk3 Vtn Rhoa Bcar1 Spp1 Rac1 Vav3 Ptk2b Itgb3 Akt1 Edil3 Cbl Col1a2 Fgf2 Tgfbr2 Hsp90aa1 Irs1 Src Angptl3 Tln1 Pxn Mfge8 F11r Adgra2 Vcl Pi4kb Kdr Pi4ka Ptpn11 Pik3c2a Csf1r Ptk2 Csf1 Vegfa Col11a1 Col11a2 Igf1 Fn1 Col2a1 Col3a1 Col1a1 Col6a1 Igf1r Col5a2 Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Rock1 Col4a5 Col6a3 Col4a6 Sdc1 Casp8 Pik3ca SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Ep300 Tuba1b Mef2d Hdac4 Acss1 Acss2 Hoxa10 Tubb2a Kat2b H1-4 Trp53 Xrcc6 Crebbp Bax Sirt3 Sirt2 Sirt1 Sirt7 Cdkn1a Foxo4 Foxo3 Foxo1 Fhl2 Ppargc1a Myod1 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Ep300 Ncoa2 Prkcg Ncoa1 Prkaca Nrip1 Kat2b Mapk8 Mnat1 Mapk1 Ccnh Vdr Cdk7 Hdac3 Rbp1 Prkca Mapk3 Crebbp Hdac1 Ncor2 Akt1 Ncoa3 Rxrb Rxra Rxrg Mapk14 Cdk1 Rara Rarb Rarg HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Rack1 Eloc Arnt Hif1a Cops5 Trp53 Rbx1 Hif3a Os9 Cdkn2a Hif1an Naa10 Egln2 Cul2 Egln3 Hsp90aa1 Vhl FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Sftpa1 Cdkn1b Ep300 Jun Cebpb Ar Nkx3-1 Shh Fos Ins2 Sp1 Col18a1 Pou2f1 Nrip1 Vtn Brca1 Esr1 Crebbp Ap1b1 Pisd Sftpd Cyp2c55 Nfia Nfic Serpina1d Scgb1a1 Nr2f2 Dscam Gcg Foxa1 Atp5pf Foxa2 Foxa3 Ncoa3 Xbp1 Ndufv3 Prdm15 Apob NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Mapk10 Ror2 Nlk Csnk1a1 Mapk8 Rhoa Nfatc2 Rac1 Pparg Tab2 Yes1 Tab1 Setdb1 Camk2a Daam1 Chd7 Flna Dvl1 Dvl2 Arrb2 Dvl3 Wnt5a Rock1 Mapk9 Map3k7 Cthrc1 Fzd2 Fzd5 Fzd7 Fzd6 Prkcz PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Src Gng2 Mapk11 Nras Gnb1 Pik3r1 Gnai1 Gnai3 Grb2 Sos1 Rhoa Esr1 Bcar1 Hras Gnaz Nos3 Gnao1 Plcb2 Igf1 Gnai2 Mmp2 Gna11 Mmp9 Gna15 Gna14 Rock2 Gnaq Igf1r Gna13 Strn Akt1 Pelp1 Esr2 Hbegf Msn Pik3ca Plcb3 Plcb1 Kras Shc1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Ctnnbip1 Jun Klf4 Pitx2 Bcl9 mt-Co2 Myf5 Mitf Incenp Tcf4 Hbp1 Trrap Mmp2 Mmp9 Hdac2 Axin2 Cul1 Ctbp1 Skp1 Myc Hdac1 Ccn1 Id2 Ctnnb1 Cdh1 Cdkn2a Ccnd2 Btrc Tert Dkk1 Ep300 Lef1 Vcan Ar Ncoa2 Snai2 Apc Tcf7l2 Camk4 Ywhah Ywhag Ywhae Ywhab Neurog1 Cacna1g Sfn Myog Mdfic Igf2bp1 Dvl3 Ccnd1 Cby1 Fgf4 Zcchc12 Tbl1xr1 Ywhaz Kcnip4 Tnik Adcy7 Tle4 Med12 Ruvbl2 Tle2 Krt1 Tle1 Tle5 Dkk4 Chd8 Sall4 T Smarca4 Tcf7 Tcf7l1 Tbl1x Sp5 Cdx4 Cdx1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Stat5a Bcl2 Irs2 Crkl Stat1 Ptpn11 Pik3r1 Vav2 Rap1a Gab1 Epor Mapk8 Sh2b3 Grb2 Tec Epo Sos1 Hras Bcl2l1 Lyn Plcg2 Inpp5d Socs3 Ptpn6 Cbl Plcg1 Mapk14 Stat5b Nfkb1 Jak2 Rapgef1 Btk Shc1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Traf6 Mapk11 Map3k3 Ccm2 Map3k6 Map3k4 Taok1 Taok3 Map3k10 Traf2 Txn Atm Rac1 Tab2 Tab1 Map3k1 Map3k5 Map3k7 Mapk14 Map2k6 Gadd45a Camk2b Map2k3 Gadd45g Gadd45b C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Max Supt3 Myc Actl6a Ppp2ca Fbxw7 Taf9 Pml Gsk3b Kat5 Kat2a Supt7l Skp2 Ruvbl2 Ppp2r5a Hbp1 Cdkn2a Trrap Axin1 Pin1 Ruvbl1 Zbtb17 Taf12 Pak2 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Abcc1 Sphk1 S1pr1 Kdr Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Pdgfrb Rhoa Vegfa Ptgs2 Pdgfb Rac1 Gnaz Gnao1 Plcb2 Gnai2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Lck Src Lyn Lama1 Nrg1 Tgfb1 Fgr Tgfb3 Hck App Prnp Slit2 Serpinc1 Gpc1 Flt1 Fgf2 Vegfa Fgfr1 Blk Smad2 Tgfbr1 Tgfbr2 Fyn Yes1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Jun Prkcg Prkcb Pla2g4a Fos Prkce Mapk8 Ednrb Ednra Mapk1 Adcy3 Adcy4 Mapk3 Adcy1 Rhoa Adcy2 Adcy8 Bcar1 Adcy5 Rac1 Adcy6 Adcy9 Edn2 Plcb2 Edn3 Prkch Cysltr2 Cysltr1 Ptk2b Akt1 Col1a2 Slc9a1 Mapk14 Slc9a3 Prkcq Src Edn1 Gnai1 Raf1 Gnai3 Prkca Crk Hras Gna12 Gnaz Gnao1 Gnai2 Map2k2 Gna11 Map2k1 Col3a1 Gna15 Gna14 Gnaq Prkcd Adcy7 Mmp1a Jak2 Plcb3 Plcb1 Trpc6 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Flt4 Pgf Flt1 Vegfb Vegfa Kdr Vegfd Vegfc Nrp1 Nrp2 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Mapk10 Jun Pik3r1 F2rl2 Nck1 Prkci Mapk8 Grb2 Map2k4 Rac1 Fyn Wasl Nck2 Nphs2 Nphs1 Cd2ap Kirrel1 Akt1 Bad Arrb2 Plcg1 Mapk9 Pard6a Pik3cb Pik3ca Tjp1 Trpc6 Prkcz LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Nfkbia Gng2 Jun Pik3r1 Gnb1 Fos Prkce Adcy3 Adcy4 Adcy1 Rhoa Adcy2 Adcy8 Bcar1 Adcy5 Rac1 Adcy6 Adcy9 Mmp2 Pld2 Ptk2b Mmp9 Lyn Prkd1 Gna13 Akt1 Lpar4 Lpar3 Lpar2 Lpar1 Adra1b Src Pxn Trip6 Gab1 Egfr Gnai1 Ptk2 Gnai3 Crk Nherf2 Hras Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Plcg1 Gsk3b Prkcd Hbegf Adcy7 Tiam1 Nfkb1 Pik3cb Plcb3 Casp3 Arhgef1 Rela BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Itga7 Itga8 Itga5 Itga6 Itga9 Itga4 Itga1 Itga2 Col18a1 Itga10 Itga11 Itgav Itgb1 Vtn Spp1 Fgg Mdk Jam2 Cd81 Plau Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Fbn1 Npnt Nid1 Cspg4 Col1a2 Plaur Lama4 Fgb Fga Tgfbi Lamb2 Lamb3 Lama2 Lamb1 Lamc2 Vegfa Tnc Col11a1 Col11a2 Fn1 Tgm2 Col2a1 Lamc1 Col3a1 F13a1 Col1a1 Lama1 Col6a1 Col5a2 Lama3 Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Itga3 Lama5 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Fga Src Itga5 Itgam Elane Egfr Itgav Vtn Pdgfrb Itgb1 Crk Bcar1 Itgb2 Rac1 Fgg Mmp3 Dock1 Fn1 Mmp9 Plau Itgb3 Tgfb1 Hgf Lrp1 Ctsg Pdgfd Fpr1 Klk4 Itga3 Fpr2 Itgb5 Gpld1 Fpr-s1 Plaur Mmp12 Ctrc Plg Mmp13 Serpine1 Vldlr Fgb VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Cdkn1b Lgals1 Itga6 Spi1 Hdac3 Itgb1 Ptpa Itgb4 Myc Hdac1 Cdkn2b Wnt5a Foxo3 Creb1 Id2 Col1a2 Rbl1 Tmeff2 Gfi1 Aldh9a1 Clu Fth1 Tmem126a Sfrp1 Dkk1 Max Tbp Ep300 Bcl2 Csde1 Tsc2 Hmgcs2 Nfyb Cebpd Nfya Nfyc Cebpa Zfp36l1 Sp1 Dnmt3a Gtf2h2 Slc11a1 Sfxn3 Ndrg1 Ndrg2 Tjp2 Mxd4 Pdgfrb Brca1 Smad2 Smad3 Ccl5 Smad4 Zbtb17 Cdkn1a Dntt Erbb2 Ccnd1 Ddit3 Cflar Gadd45a Irf8 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Nrg1 Erbb2 Erbb4 Egfr Hbegf Ereg Nrg2 Areg Btc Nrg4 Nrg3 Tgfa Erbb3 Egf Hsp90aa1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Gng2 Gnb1 Grk2 Tuba1b Ranbp2 Hdac4 Ube2i Tubb2a Ran Ankra2 Hdac3 Hdac5 Bcor Hdac7 Esr1 Rfxank Hdac6 Hdac9 Mef2c Camk4 Ywhae Gata2 Ywhab Ncor2 Hdac11 Hdac10 Srf Bcl6 Hsp90aa1 Nr3c1 Gata1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Wwp1 Fkbp1a Pml Xiap Eif2a Smurf1 Daxx Tgfb1 Tgfb3 Ppp2ca Arrb2 Ppp1ca Cav1 Ctnnb1 Map3k7 Ccn2 Pard6a Tgfbr1 Tgfbr2 Shc1 Grb2 Sos1 Dynlrb1 Tgfbrap1 Nedd4l Zfyve16 Ppp2cb Smad2 Smurf2 Smad3 Strap Tab2 Dab2 Smad4 Tab1 Dact2 Tgfbr3 Sptbn1 Ppp2r2a Ywhae Rnf111 Pdpk1 Ppp1r15a Camk2a Zfyve9 Bambi Smad7 Yap1 Itch Axin1 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Cdh1 Itgb7 Itgae JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Jun Crkl Dbnl Lcp2 Prkcb Map3k8 Grap2 Mapk8 Map3k7 Map4k1 Crk Map2k4 Lat Map3k1 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Ep300 Bcl2 Chp1 Rcan2 Fkbp1a Prkcg Prkcb Prkaca Prkce Mef2d Nr4a1 Cabin1 Csnk1a1 Ran Mapk8 Akap5 Nfatc1 Prkca Mapk3 Nfatc3 Nfatc2 Crebbp Bax Prkch Camk4 Bcl2l1 Ywhah Ywhag Map3k1 Ywhae Ywhab Fkbp8 Nup214 Map3k8 Sfn Bad Gsk3b Prkcd Kpnb1 Ywhaz Mapk9 Mapk14 Pim1 Casp3 Prkcq Prkcz Rcan1 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Inpp5d Map3k14 Ptpn6 Akt1 Cbl Vav1 Pten Itk Prkcq Gab2 Shc1 Lck Traf6 Lcp2 Ptpn11 Nck1 Rap1a Grap2 Trpv6 Map4k1 Grb2 Prkca Sos1 Csk Hras Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Flna Ptprc Dbnl Map3k8 Sla2 Orai1 Stim1 Stk39 Plcg1 Rassf5 Cd3e Was Fyb1 Ikbkb Sh3bp2 Cd4 H2-Eb1 Ikbkg Cd3g Cd247 Cd3d Cd28 Cd86 Cd80 Kras VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Prkcb Ptpn11 Prkaca Pik3r1 Nck1 Mapk1 Flt1 Prkca Shc2 Mapk3 Vegfa Nos3 Nrp1 Nrp2 Pdpk1 Pgf Vegfb Cd2ap Akt1 Cbl Hif1a Plcg1 Cav1 Pik3ca Hsp90aa1 Rasa1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Ednra Grb2 Sos1 Edn1 Hras Egf Mtor Egfr Shc1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Gng2 Lgals3 Gli2 Shh Prkaca Gnb1 Smo Ptch1 Csnk1a1 Pias1 Gnai1 Csnk1g3 Csnk1g1 Gnai3 Csnk1g2 Rbbp4 Rbbp7 Crebbp Sin3a Gnaz Sin3b Gnao1 Gnai2 Csnk1d Csnk1e Hdac2 Map2k1 Foxa2 Hdac1 Akt1 Arrb2 Fbxw11 Gsk3b Prkcd Sap30 Rab23 Gli1 Gli3 Mtss1 Ift88 Kif3a Sap18b Stk36 Ift172 Sufu Btrc Spop INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Irs1 Exoc1 Exoc2 Grb10 Eif4ebp1 Ptpn11 Exoc7 Pik3r1 F2rl2 Ins2 Nck1 Rhoq Trip10 Dok1 Prkci Sh2b2 Insr Grb2 Ptpn1 Sos1 Crk Hras Sgk1 Ptpra Pdpk1 Nck2 Inpp5d Akt1 Cbl Foxo3 Akt2 Cav1 Grb14 Pard6a Pik3ca Sorbs1 Exoc3 Exoc4 Rapgef1 Exoc5 Shc1 Prkcz Exoc6 Rasa1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfd Pdgfa Pdgfrb Pdgfb Pdgfc Pdgfra EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Src Pak1 Inppl1 Epha2 Pik3r1 Vav2 Cbl Ptk2 Grb2 Tiam1 Rhoa Bcar1 Rac1 Arhgap35 Pik3ca Vav3 Acp1 Shc1 Efna1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Stat3 Stat1 Pik3r1 Mapk8 Sh2d2a Mapk1 Mapk3 Brk1 Ksr1 Map2k4 Baiap2 Rac1 Arpc1b Actr2 Pld1 Actr3 Pld2 Arpc3 Map3k1 Arpc2 Arpc5 Arpc4 Ppp2ca Srf Slc9a1 Smad1 Ppp2r1a Src F2rl2 Gab1 Capn2 Usp6nl Grb2 Prkca Sos1 Hras Ywhah Ppp2r2a Ywhag Ywhae Pdpk1 Ywhab Braf Sfn Elk1 Egr1 Bad Prkcd Ywhaz Mapk9 Dusp1 Mapk7 Zfp36 Kras Map3k2 Prkcz Mylpf Ralgds Jun Arf4 Ppp5c Diaph3 Nras Map2k5 Dusp6 Fos Vav2 Rab5a Rin1 Pebp1 Rps6ka4 Rps6ka5 Atf2 Bcl2l1 Wasl Eps8 Akt1 Mtor Creb1 Iqgap1 Rala Egfr Raf1 Egf Mef2c Map2k2 Map2k1 Rictor Mapkap1 Mlst8 Nckap1 Pik3cb Wasf2 Pik3ca Cyfip2 Rps6ka3 Abi1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Ywhae Ppp2r5d Clip1 Katna1 Pafah1b3 Lrpap1 Pafah1b2 Pafah1b1 Cdk5r2 Dab1 Dync1h1 Cdk5 Cdk5r1 Ndel1 Reln Dcx Pla2g7 Rhoa Iqgap1 Abl1 Rac1 Nudc Vldlr Map1b SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Src Cdkn1a Egr1 Tuba1b Itga1 Ccna2 Rock1 Mapk1 Ptp4a3 Mapk3 Agt Itgb1 Ptp4a2 Rhoc Rhoa Bcar1 Rabggta Rabggtb Rac1 Atf5 Cdk2 Ccne1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Lck Src Ptpn13 Pik3r1 Mapk8 Itga2b Map2k4 Rac1 Blk Rgs3 Fyn Yes1 Ephb1 Ephb2 Itgb3 Ephb4 Nck2 Lyn Efnb1 Efnb2 Fgr Hck Dnm1 Map3k7 Tiam1 Pik3ca VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Mapk11 Itga5 Pik3r1 Itga4 Itga1 Itga2 Mapk1 Grb2 Mapk3 Itgb1 Sos1 Crk Map2k4 Vegfd Fn1 Vegfc Flt4 Col1a1 Akt1 Creb1 Col1a2 Mapk14 Rps6ka1 Pik3ca Shc1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Src Pxn Arrb1 Git1 Epha2 Nck1 Egfr Arf6 Itga2b Gulp1 Fbxo8 Egf Ipcef1 Cyth2 Acap2 Kif13b Gna11 Cyth3 Lhcgr Iqsec1 Gna15 Arap2 Gna14 Itgb3 Gnaq Adap1 Hgf Arrb2 Tshr Agtr1a Met Adrb2 Acap1 Efna1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Mapk11 Trp63 Pml Mdm2 Jag2 Plk3 Bax Jak1 Pin1 Sirt1 Casp2 Prkacb Pfdn5 Fbxo45 Tuba1a Ccne2 Myc Bub1 Pea15 Il1rap Clca2 Ndufs2 Hagh Plk1 Gramd4 Foxo3 Aen Dcp1b Trp73 Rnf43 Dedd Mapk14 Flot2 Afp Hsf1 Wt1 Bak1 Bub3 Cdk1 Nsg1 Il4ra Gdf15 Serpine1 Plpp1 Ep300 Bin1 Sp1 Rad51 Bcl2l11 Nedd4l Chek1 Abl1 Cdk6 Serpina1d Ada Ntrk1 Cdk2 Rack1 Cdkn1a Sfn Wwox Ccna2 Brca2 Kat5 Hey2 Yap1 Rb1 Itch Rchy1 Fasn Fas Rela Gata1 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Src Gng2 Mapk11 Arrb1 Nras Gnb1 Pik3r1 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Gnaz Gnao1 Gnai2 Map2k2 Map2k1 Pdpk1 Akt1 Rictor Dnm1 Mtor Ccl11 Mapk14 Mapkap1 Cxcl9 Map2k6 Mlst8 Pik3cb Cxcl11 Pik3ca Cxcl10 Cxcr3 Map2k3 Pf4 Cxcl13 Kras IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Stat5a Cebpb Ptpn11 Prkaca Pik3r1 Grb2 Csf2rb2 Cish Bcl2l1 Ywhag Prkacb Inpp5d Hdac1 Id1 Ywhaz Pim1 Stat5b Jak2 Pik3ca Osm Il3ra Shc1 Cnksr1 Gab2 Srp9 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Gng2 Mapk11 Prkcg Prkcb Prkaca Gnb1 Prkce Grk2 Rhoa Rac1 Blk Plcb2 Fyn Syk Prkch Yes1 Lyn Vcam1 Gna13 Akt1 Fgr Hck Pik3cg Pik3r6 Arrb2 Arr3 Mapk14 Icam1 Gnb5 Rab11a Prkcq Ptgdr Lck Ptgir Src Tbxa2r Prkg1 Egfr Prkca Nherf1 Gna12 Nos3 Egf Gnai2 Tgm2 Gna11 Gna15 Gna14 Gnaq Dnm1 Rock1 Prkcd Sele Arhgef1 Prkcz Grk3 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Col17a1 Cd9 Itga6 Pmp22 Il1a Pik3r1 Egfr Lamb2 Lamb3 Lama2 Grb2 Lamb1 Prkca Itgb1 Lamc2 Mst1 Itgb4 Hras Rac1 Erbb3 Casp7 Egf Ywhah Ywhag Lamc1 Ywhae Ywhab Lama1 Lama3 Akt1 Sfn Erbb2 Rxrb Rxra Rxrg Ywhaz Cdh1 Lama5 Met Mst1r Pik3ca Lama4 Shc1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Nras Clip1 Eif4ebp1 Srebf1 Pml Mapk1 Eif4e Mapk3 Pld1 Pld2 Akt1 Mtor Fbxw11 Btrc Eif4a1 Ccne1 Irs1 Tsc2 Prr5 Rraga Ddit4 Rragb Rragc Rragd Tsc1 Eif4b Raf1 Ulk1 Ulk2 Rb1cc1 Rrn3 Prkca Poldip3 Pdcd4 Atg13 Eef2 Hras Sgk1 Map2k2 Ywhah Cdk2 Ywhag Map2k1 Ywhae Pdpk1 Ywhab Braf Sfn Rictor Rptor Ikbkb Ywhaz Mapkap1 Rps6ka1 Mlst8 Deptor Akt1s1 Eef2k Yy1 Kras Ppargc1a ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Chuk Nfkb1 Map3k14 Btrc Nfkb2 Relb DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Nlrc4 E2f2 Prdm1 Prkab1 Ppm1j Ctsd Trp63 Col18a1 Mdm2 Pml Plk3 Mcl1 Spp1 Bax Pou4f1 Edn2 Trrap Pou4f2 Mmp2 Cd82 Taf9 Cav1 Hspa1a Tgfa Pten E2f3 Tsc2 Nfyb Nfya Nfyc Pcna Ndrg1 Snai2 Apc Trp53 Sfn Hgf Bcl2a1d Serpinb5 Carm1 Bdkrb2 Met Igfbp3 Gadd45a Dusp5 Rchy1 Dusp1 Jun Epha2 Perp Cse1l Apaf1 Ccng1 Pidd1 Cop1 Bcl2l1 Hdac2 Casp1 Foxa1 Tfdp1 Trp73 Lif Afp Bcl6 Bak1 Gdf15 Serpine1 Atf3 Dkk1 Bcl2 Ep300 E2f1 Vcan Ddit4 Sp1 Egfr Kat2a Vdr Casp6 Drosha Crebbp Ccnk Pcbp4 Tap1 Hic1 Ppp1r13b Msh2 Tyrp1 Tnfrsf10b Sh2d1a Sesn1 Map4k4 Rgcc Steap3 Cdkn1a Jmy Fdxr Ddx5 Trp53bp2 Btg2 Rrm2b Ddb2 Prmt1 Bcl2l14 Rps27l Gpx1 Bcl2l2 Bnip3l Rnf144b Trp53inp1 Triap1 Irf5 Aifm2 Rb1 Dgcr8 Htt Scn3b Bid Zfp385a Arid3a Smarca4 Pms2 Cx3cl1 Pycard Mlh1 Fas Tigar Cebpz LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkaca Prkce Lpar4 Creb1 Adcy3 Adcy7 Adcy4 Adcy1 Rps6ka5 Adcy2 Adcy8 Adcy5 Adcy6 Adcy9 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Src Nme1 Snx1 Adam10 Dnm2 Bdnf Slit1 Gdnf Cbll1 Gfra1 Dsp Cables1 Ctnnd1 Rab5a Mep1b Igf2 Egfr Robo1 Arf6 Cdh2 Zbtb33 Hgs Ptpn1 Hras Crebbp Abl1 Rac1 Mmp3 Gna12 Fyn Egf Ntrk2 Rab7 Mmp7 Igf1r Gna13 Ptpn6 Ctnnb1 Cdh1 Tiam1 Rin2 Iqgap1 Met Jup Casp3 Ret Ctnna1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Nfkbia Ppp2r5d Git1 Birc5 Prkaca Mdm2 Aurkaip1 Ran Oaz1 Tacc1 Cpeb1 Ndel1 Aurkb Trp53 Dlgap5 Ajuba Tdrd7 Brca1 Fzr1 Pak1 Tacc3 Akt1 Gsk3b Tpx2 Ckap5 Gadd45a Aurka Arhgef7 Cenpa Cdc25b Rasa1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Cblb Nfkbia Mapk10 Traf6 Jun Stat5a Mapk11 Pik3r1 Il4 Mapk8 Cd40lg Traf2 Fcamr Traf3 Cd40 Map2k4 Tdp2 Tnfaip3 Jak3 Bcl2l1 Map3k1 Myc Map3k14 Akt1 Pik3cg Pik3r6 Birc3 Mapk9 Birc2 Mapk14 Nfkb1 Pik3cb Pik3ca Traf1 Rela VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network C3 Ncoa2 Ncoa1 Nr0b1 Ncoa3 Esr2 Smarce1 Ube2m Uba3 Nedd8 Smarcb1 Zfp709 Ddx54 Smarca4 Nr0b2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurka Aurkb LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Mark2 Tsc2 Ctsd Prkaca Tsc1 Trp53 Esr1 Stk11ip Stk26 Mark4 Smad4 Crtc2 Stradb Ywhah Smarcd3 Ywhag Strada Ywhae Cab39 Etv4 Stk11 Ywhab Sik3 Myc Sik2 Sik1 Psen2 Sfn Brsk2 Brsk1 Mtor Gsk3b Rptor Creb1 Cdc37 Ywhaz Mlst8 Akt1s1 Hsp90aa1 Ezr EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb3 Ephb4 Efnb1 Efnb2 Ephb1 Ephb2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Map2k5 Nras Fos Rap1a Cdk5 Raf1 Mapkapk2 Cdk5r1 Mapk1 Ntf3 Mapk3 Rps6ka5 Hras Rit1 Rit2 Mef2c Ehd4 Map2k1 Trpv1 Braf Rap1b Elk1 Egr1 Srf Creb1 Prkcd Mapk14 Map2k6 Rps6ka1 Map2k3 Mapk7 Kras Map3k2 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Map3k3 Stat1 Nsmaf Madd Tnfrsf1a Sqstm1 Bag4 Tradd Prkci Traf2 Txn Tnfaip3 Tab2 Smpd2 Tab1 Map3k1 Map4k4 Rack1 Chuk Nrk Map4k5 Map3k5 Map4k3 Tnf Tnfrsf1b Birc3 Adam17 Cav1 Cyld Ikbkb Map4k2 Birc2 Map3k7 Rffl Ikbkg Tnik Map2k7 Nfkb1 Casp8 Smpd1 Map2k3 Traf1 Ripk1 Prkcz Rela Fadd FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Foxf1 Abcc8 Kcnj11 Cebpb Alb Apoa1 Cebpd Hnf1a Cpt1b Cebpa Cpt1c Ins2 Sp1 Hadh Dlk1 G6pc1 Hnf4a Foxa1 Foxa2 Foxa3 Akt1 Creb1 Pklr Tat Afp Aldob Nkx2-1 Acadvl Alas1 F2 Ttr Tfrc Igfbp1 Ucp2 Slc2a2 Pck1 Nf1 Pdx1 Acadm Gck Nr3c1 Cpt1a Bdh1 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Jun Diaph3 Rasgrf1 Pik3r1 Prkce Vav2 Mapk8 Mapk1 Mapk3 Arhgdia Bcar1 Map2k4 Baiap2 Atf2 Rac1 Iqgap3 Arpc1b Actr2 Pld1 Actr3 Yes1 Pak2 Arpc3 Map3k1 Wasl Arpc2 Pak1 Arpc5 Arpc4 Map3k11 Eps8 Cbl Mtor Ctnnb1 Mapk14 Cdh1 Pard6a Iqgap1 Cfl1 Map2k3 Myl2 Ctnna1 Limk1 Arhgef7 Limk2 Arhgef6 Src Exoc7 F2rl2 Cdc42bpa Septin2 Pax6 Hes5 Raf1 Tnk2 Apc Hras Braf Gsk3b Mapk9 Map2k7 Map2k6 Tiam1 Pak4 Pik3ca Dlg1 Prkcz CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Gng2 Stat5a Stat3 Stat1 Pik3r1 Gnb1 Cxcl12 Grk2 Hgs Rhoa Bcar1 Rac1 Blk Plcb2 Fyn Yes1 Ptk2b Mmp9 Pak1 Lyn Inpp5d Gna13 Ptpn6 Akt1 Fgr Hck Pik3cg Pik3r6 Mtor Arrb2 Vav1 Foxo1 Arr3 Stat5b Cfl1 Limk1 Lck Src Pxn Ptpn11 Cxcr4 Gnai1 Ptk2 Rgs1 Gnai3 Ubqln1 Vps4a Vps4b Grk6 Stat2 Rhoc Ralb Crk Csk Rhob Pag1 Gnaz Gnao1 Gnai2 Pdpk1 Rack1 Ptprc Rap1b Rictor Dnm1 Bad Cd3e Cd4 H2-Eb1 Ssh1 Mapkap1 Mlst8 Cd3g Cd247 Cd3d Jak2 Itch Pik3cb Pik3ca Plcb3 Plcb1 Prkcz P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Ywhae Tcf3 Mapk11 Tsc2 Ywhab Sfn Hspb1 Mapkapk3 Creb1 Srf Raf1 Mapkapk2 Ywhaz Mapk14 Etv1 Lsp1 Cdc25b Ywhah Th Ywhag PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Dkk1 Ppp2r5d Jun Adam10 Psen1 Ppard Hnf1a Nlk Fos Dtx1 Dll1 Csnk1a1 Wnt1 Apc Mapk1 Mapk3 Nkd1 Dkk2 Crebbp Frat1 Tab1 Ctbp1 Myc Hdac1 Dvl1 Lrp6 Ccnd1 Wif1 Fbxw11 Gsk3b Ctnnb1 Map3k7 Fzd1 Tle1 Kremen2 Tle5 Btrc Rbpj Axin1 Ncstn Notch1 Aph1b VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Ep300 Wwp1 Mfge8 Shh Sp1 Cables1 Perp Trp63 Pml Mdm2 Jag1 Vdr Itgb4 Hbp1 Abl1 Bax Dhrs3 Traf4 Ogg1 Spata18 Tfap2c Nqo1 Ada Smarcd3 Evpl Ssrp1 Dicer1 Cdkn1a Chuk Fdxr Clca2 Plk1 Aen Serpinb5 Prkcd Ikbkb Flot2 Egr2 Itga3 Igfbp3 Cdkn2a Gadd45a Itch Gdf15 Btrc Fas Gpx2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Ep300 Cebpb Crkl Il1b Stat3 Stat1 Ptpn11 Pik3r1 Rap1a Pias1 Ifng Socs1 Mapk1 Ptpn2 Mapk3 Ifngr1 Crebbp Jak1 Casp1 Map3k1 Map2k1 Pias4 Dapk1 Ptges2 Camk2a Irf9 Smad7 Map3k11 Akt1 Rap1b Cbl Camk2d Mtor Prkcd Camk2g Jak2 Pik3ca Camk2b Irf1 Rapgef1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Ap2m1 Gbf1 Pip5k1a Uso1 Kdelr1 Gga3 Ap2a1 Asap1 Arfip2 Gosr2 Cltb Arfgap1 Copa Cd4 Clta Rac1 Arf1 Cyth2 Pld2 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Traf6 Jun Myd88 Il1r1 Il1b Map3k3 Irak4 Il1a Pik3r1 Sqstm1 Prkci Mapk8 Tab2 Tab1 Casp1 Chuk Il1rap Ube2v1 Ikbkb Ticam2 Map3k7 Irak3 Ikbkg Erc1 Tollip Map2k6 Il1r2 Il1rn Nfkb1 Ube2n Pik3ca Irak1 Prkcz Rela GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Krt14 Mapk10 Jun Stat5a Mapk11 Ppp5c Pomc Krt5 Stat1 Prkaca Fos Nr4a1 Il2 Il4 Mdm2 Pou2f1 Ifng Cdk5 Cdk5r1 Mapk8 Mapk1 Spi1 Nfatc1 Csf2 Mapk3 Fgg Bax Hdac2 Prkacb Hdac1 Akt1 Creb1 Mapk14 Afp Stat5b Icam1 Gata3 Hsp90aa1 Nr3c1 Tbp Ep300 Ncoa2 Ncoa1 Il5 Prl Csn2 Trp53 Crebbp Sgk1 Ywhah Cdkn1a Sfn Egr1 Gsk3b Il6 Mapk9 Il13 Mmp1a Nr1i3 Nfkb1 Tsg101 Kmt5b Smarcc1 Fkbp5 Sele Vipr1 Tbx21 Pou1f1 Smarca4 Smarcd1 Irf1 Cga Fkbp4 Pck2 Krt17 Rela Pbx1 Smarcc2 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Stambp Cblb Src Amph Sh3gl2 Chmp3 Epn1 Nras Zfyve28 Pik3r1 Rab5a Egfr Ptk2 Raf1 Hgs Grb2 Sos1 Ube2d3 Ube2d1 Hras Spry2 Egf Usp8 Synj1 Cbl Dnm1 Itsn1 Lrig1 Sh3kbp1 Eps15 Tsg101 Pik3cb Pik3ca Arhgef7 Kras Shc1 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Cdkn1b E2f2 Uxt Ces1d Tfdp2 Cdkn2c Cbx5 Tyms Mybl2 Sult2a1 Ranbp1 Ccnd3 Mcm3 Ces2h Ces4a Pola1 Prmt5 Dhfr Apaf1 Rybp Orc1 Ces3b Mcl1 Rrm1 Hbp1 Ces5a Rrm2 E2f6 E2f7 Trrap Casp7 Wasf1 Sirt1 Cdc6 Plau Ccne2 Myc Hdac1 Cdc25a Tfdp1 Trp73 Tfe3 Rbl1 Cdkn2a Cdk1 Serpine1 Xrcc1 E2f3 Ccne1 Smarca2 Tk1 Ep300 E2f1 Trim28 Cebpa Sp1 Kat2b Kat2a Topbp1 Rbbp4 Brca1 Crebbp Atm Rbl2 Hic1 Cdk2 E2f4 Cdkn1a E2f5 Ccna2 Rb1 Rbbp8 Yy1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Nfkbia Ripk2 Traf6 Bcl10 Chuk Tnf Tnfrsf1a Cyld Ran Ikbkb Birc2 Ikbkg Erc1 Prkca Ube2d3 Nfkb1 Atm Tnfaip3 Btrc Nod2 Rela Malt1 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Epha5 Fyn Efna5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Map3k14 Ptpn6 Akt1 Cbl Vav1 Prkcq B2m Shc1 Lck Traf6 Lcp2 Cd8a Cd8b1 Rap1a Grap2 Trpv6 Grb2 Prkca Sos1 Csk Hras H2-Q10 Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Ptprc Map3k8 Orai1 Stim1 Plcg1 Rassf5 Cd3e Ikbkb Ikbkg Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Kras REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Cdkn1b Jun Ube3a Fos Il2 Ifng Mapk1 Smg5 Mapk3 Sin3a Sin3b Terf1 Smg6 Tinf2 Parp2 Hdac2 Tnks Dkc1 Pot1 Pif1 Wrn Myc Acd Hdac1 Znfx1 Tgfb1 Terf2ip Akt1 Hnrnpc Pinx1 Mtor Mxd1 Sap30 Wt1 Terf2 Sap18b Hsp90aa1 Tert Max Ifnar2 E2f1 Mre11a Nbn Sp1 Egfr Sp3 Rad50 Rbbp4 Xrcc6 Rbbp7 Esr1 Xrcc5 Blm Atm Abl1 Rad9a Smad3 Egf Nr2f2 Ywhae Hus1 Ccnd1 Rad1 Nfkb1 Irf1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Cdkn1b Jun E2f2 Mapk11 Mitf Mdm2 Ccnd3 Spi1 Hdac3 Csf2 Atf2 Smarcb1 Pparg Sirt1 Ctbp1 Hdac1 Ppp2ca Suv39h1 Tfdp1 Brd2 Pax3 Aatf Rbp2 Atf7 Mapk14 Ckm Dnmt1 Taf1 Cdkn2a Ccnd2 Ubtf E2f3 Ccne1 Myod1 Tbp Ep300 E2f1 Cebpb Elf1 Cebpd Cebpa Gsc Raf1 Runx2 Cbx4 Skp2 Rbbp4 Crebbp Abl1 Cdk6 Sftpd Mef2c Cdk4 Cdk2 E2f4 Cdkn1a Ccna2 Ccnd1 Mapk9 Rb1 Met Tgfb2 Smarca4 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Pias4 Ctdsp1 Nup214 Ube2i Kpnb1 Mapk1 Ppm1a Mapk3 Nup153 Ctdspl Tgfbrap1 Smad2 Smad3 Smad4 Map3k1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Jun Fos Cxcl12 Npm1 Ets1 Hdac7 Mcl1 Itgb2 Hnf4a Gata2 Tff3 Ldha Akt1 Hmox1 Creb1 Id2 EG433182 Plin2 Adm Tfrc Cp Igfbp1 Pfkfb3 Serpine1 Nt5e Car9 Eng Pgm1 Fech Pkm Gck Aldoa Tert Abcb1a Pfkl Ep300 Rora Hk2 Hk1 Edn1 Bhlhe41 Ncoa2 Ncoa1 Sp1 Cxcr4 Ndrg1 Cops5 Epo Bhlhe40 Vegfa Furin Crebbp Egln3 Lep Smad3 Cited2 Pgk1 Smad4 Slc2a1 Abcg2 Tf Arnt Hif1a Nos2 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Crkl Grin2a Mapk8ip1 Pik3r1 Lrpap1 Rap1a Pafah1b1 Dab1 Cdk5 Cdk5r1 Mapk8 Reln Itgb1 Fyn Map1b Nck2 Arhgef2 Map3k11 Akt1 Cbl Gsk3b Map2k7 Itga3 Grin2b Pik3ca Vldlr Rapgef1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Chuk Pik3r1 Dap3 Tnfsf10 Ikbkb Tradd Mapk8 Mapk1 Ikbkg Traf2 Mapk3 Cflar Map2k4 Pik3cb Casp8 Pik3ca Smpd1 Ripk1 Tnfrsf10b Fadd Map3k1 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Gng2 Mapk11 Gnb1 Crh Mapk9 Mapk14 Mapk8 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Src Stat5a Stat3 Stat1 Kdr Pik3r1 Eif2ak2 Ins2 Csf1r Itga1 Lman1 Gab1 Egfr Pias1 Rab4a Csf1 Insr Grb2 Stat6 Ptpn2 Ptpn1 Pdgfrb Itgb1 Sos1 Eif2a Vegfa Pdgfb Crebbp Jak3 Jak1 Egf Hgf Kpnb1 Stat5b Met Pik3cb Pik3ca Shc1 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Ctdsp1 Grem1 Ahsg Sostdc1 Rgmb Rgma Xiap Mapk1 Hjv Chrd Cer1 Fst Bmp4 Nog Bmpr1a Bmp6 Zfyve16 Ski Bmp2 Smad6 Smurf2 Tab2 Smad4 Tab1 Smurf1 Ppp1r15a Bambi Smad7 Nup214 Ppp1ca Gsk3b Map3k7 Bmpr2 Smad1 Ppm1a Smad9 Ctdspl Bmp7 Smad5 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events Gna15 Gna14 Gng2 Rock2 Gnaq Gna13 Gnb1 F2rl2 Rock1 Rhoa F2 F2rl3 Plcb2 Myl2 Gna11 FSH%NETPATH%FSH FSH Map2k2 Grk4 Fshb Fshr Akt2 Grk6 Cga Appl1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Med23 Med12 Med1 Dhh Hhip Ihh Stk36 Prkaca Ctnnb1 Gli1 Med6 Gli2 Cdk8 Ywhae Grk2 Ptch2 Sap18b Ptch1 Dyrk1a Sufu Boc Arrb2 Gas1 Kif27 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Creb1 Ar Hdac1 Hspb1 Akt1 Pik3r1 Ptk2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Runx2 Rb1 Kat2b Tgfbr3 Prkar2a Trim33 Pml Ski Map2k3 Samd3 Mef2a Mef2c Brca1 Zfyve9 E2f4 Cdkn1a Tgfbr2 Arrb2 Ar Hdac1 Akt1 Pik3r1 Ptk2 Atf2 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Ube2i Myc Sox9 Skp1 Pdk1 Pard6a Ctnna2 Ctnna1 Dcp1a Rbx1 Eid2 Ube2d3 Ube2d1 Nup153 Trp73 Sik1 Btrc Cdc25a Atf3 Jund Pxn Sdc2 Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Pik3ca Ccnd1 Vdr Trp53 Cav1 Sptbn1 Esr1 Ppp2r2a Stk11 Hspa8 Map4k1 Ppp1r15a Nup214 Wwtr1 Sparc Cdk6 Smad4 Fnta Cdk4 Cul1 Cdc16 Tab1 Junb Daxx Smad6 Hnf4a Ing2 Xpo1 Xpo4 Pdpk1 Ctcf Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Gsk3b Rbl2 Zeb2 Anapc10 Smurf1 Crk Pik3r2 Eng Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Prkar1b Nfyc Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Fosb Runx3 Cd44 TCR%NETPATH%TCR TCR Map2k2 Ctnnb1 Dyrk1a Creb1 Akt1 Pik3r1 Ptk2 Atf2 Mapk1 Mapk3 Pxn Gsk3b Crk Pik3r2 Pard3 Prkd1 Prkd2 Eno2 Crkl Cd2ap Acta1 Plcg1 Cblb Plcg2 Ly9 Wipf1 Prkcd Itsn2 Rasgrp1 Rasgrp2 Vasp Arhgef7 Arhgef6 Rasa1 Txk Arhgef2 Unc119 Cabin1 Pttg1ip Pik3ap1 Bcl10 Grap Lnpep Pag1 Lyn Egr1 Nfkbib Fyb1 Tfrc Pik3c2b Cgn Homer3 Nfkbia Crebbp Kirrel1 Slamf6 Cyfip1 Grb2 Ada Ikbkb Itk Gdi2 Shb Tsg101 Dyrk1b Cltc Cd28 Nfkb1 Pgam1 Jak3 Ptprh Vav3 Rap1a Diaph1 Syk Skap2 Skap1 Gab2 Vav1 Vav2 Card11 Bdh1 Ldha Ldhb Tuba4a Prpf4b Icos Zdhhc17 Golga5 Ctla4 Was Cd3g Actr10 Cd3e Cd3d Dusp3 Def6 Pak1 Nfam1 Caskin2 Cct8 Dpysl2 Git2 Ahcy Grap2 Elp3 Mpzl1 Map2k1 Rapgef1 Hnrnph3 Nedd9 Stat1 Dbnl Mapk7 Sh2d3c Mapk8 Tuba1a Sla Map3k8 R3hcc1l Sit1 Dgka Erbin Cd86 Sdcbp Cd84 Sh2d2a Cd82 Cd80 Snrnp70 Lax1 Hsp90ab1 Rela Mtmr10 Dok1 Dok2 Hgs Fcrl5 Stk39 Pkp4 Flnb Anxa2 Raf1 Inpp5d Shc1 Pi4ka Stk4 Acly Ripk2 Elmo1 Abl1 Bmf Ptprc Tubb5 Ppp3cb Eprs1 Ptpra Pstpip1 Acbd6 Fer Ogn Cdk1 Lat Itpr1 Zap70 Wdr1 Arhgdib Ddx3x Txnrd1 Pecam1 Nfatc1 Hdac7 Acp1 Pgm1 Nck1 Nfatc2 Stam2 Anxa11 Msl2 Adam9 Dnm2 Epha3 Ddx49 Pkm Lck Evl Sos2 Lcp2 Sos1 Lpxn Ywhaz Eif3m Ubash3b Atp1a1 Src Atp1a3 Ptpn6 Trim25 Cbl Cebpb Dock2 Cd2 Muc1 Cd4 Trat1 Cd5 G6pdx Cd7 Ptpn11 Ptpn12 Mapk14 Arhgap35 Dnajb1 Ptk2b Sh2b3 Sh3bp2 Tec Khdrbs1 Ptpn22 Chuk Ran Mapk11 LEPTIN%NETPATH%LEPTIN Leptin Runx2 Esr1 Akt1 Src Ptk2 Jak3 Mapk1 Shc1 Plcg1 Plcg2 Khdrbs1 Chuk Crp Erbb2 Irs1 Irs4 Eif4ebp1 Pde3a Socs7 Gsk3b Prkaa1 Prkaa2 Gnaq Slc2a4 Fyn Jak1 Nos3 Cfl2 Sh2b1 Egfr Eif4e Stat1 Gsk3a Cdk5 Itgb5 Mapk8 Lep Nfkbia Limk1 Prkce Rps6ka2 Acacb Ncoa1 Igf1r Grb2 Ikbkb KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Matk Socs6 Ptpru Gys1 Akt1 Jak2 Sh3kbp1 Pik3r1 Mad2l1 Atf2 Rela Fgr Hck Prkcb Rps6ka1 Mapk1 Kit Tnfrsf10b Prkca Il7r Spred1 Ezr Raf1 Spred2 Inpp5d Grb7 Ep300 Mtor Crkl Epor Csf2rb2 Mapk12 Yes1 Cblb Abl1 Kitlg Rdx Msn Wipf1 Stat5a Stat5b Fes Cdk2 Hras Rasa1 Grap Jun Pik3ca Sos1 Cltc Src Jak3 Ptpn11 Mapk14 Tec Was Eif4ebp1 Gsk3b Crk Fyn Stat1 Mapk8 Socs1 Mitf Socs5 Socs4 BCR%NETPATH%BCR BCR Rb1 Hck Prkcb Rps6ka1 Prkd1 Crkl Plcg1 Prkcd Cdk2 Cd72 Stap1 Elk1 Sla2 Rasa1 Chst15 Malt1 Prkcq Gtf2i Tcl1 Rasgrp3 Btk Bcl10 Pip4k2b Pip4k2c Pip4k2a Cd79a Lyn Cd79b Pik3cg Cdk7 Bcl6 Btla Hnrnpk Itpr2 Bank1 Nfatc3 Cd22 Plekha2 Plekha1 Grb2 Hcls1 Lat2 Ikbkb Blnk Itk Ptpn18 Ccl4 Casp7 Mapkapk2 Casp9 Sh2b2 Fcgr2b Bax Stat3 Pip5k1c Pip5k1b Pip5k1a Vav1 Card11 Rapgef1 Ctnnb1 Nedd9 Stat1 Creb1 Akt1 Ptk2 Atf2 Rela Dok1 Mapk1 Shc1 Itpr1 Zap70 Nck1 Nfatc2 Jun Lck Sos2 Sos1 Map4k1 Ptpn6 Junb Mapk14 Pdpk1 Sh3bp2 Tec Foxo3 Chuk Fos Eif4ebp1 Gsk3b Crk Fyn Pik3r2 Gsk3a Bcar1 Fosb TNFALPHA%NETPATH%TNFALPHA TNFalpha Prkca Ep300 Stat5a Gtf2i Casp7 Mapkapk2 Bax Nkiras1 Rpl4 Nkiras2 Erbb3 Tbkbp1 Trib3 Rps11 Tbk1 Tnfrsf11a Dpf2 Kcnq1 Tax1bp1 Polr1b Polr1c Txnip Polr1a Polr1d Polr1e Actl6a Smarce1 Tifa Cdc37 Cdc34 Rffl Rasa3 Akt2 Nfkbiz Txn Glg1 Sec16a Cradd Dcaf7 Nfkbie Diablo Rel Faf1 Ikbkg Tnfrsf8 Ikbke Mark2 Tnfrsf1b Rfk Akap8 Psmb5 Ywhae Gab1 Bcl2l1 Rack1 Fkbp5 Fbxw7 Fadd Smpd3 Psmc2 Psmc1 Psmc3 Map2k5 Creb1 Itch Bid Hdac1 Commd1 Hspb1 Akt1 Trpc4ap Psmd7 Ptk2 Psmd6 Fancd2 Psmd3 Psmd2 Elp1 Psmd1 Mapk1 Ktn1 Pkn1 Map3k11 Lrpprc Mapk9 Brinp1 Mapk3 Nr2c2 Nlrp4e Ube2i Tnf Map3k5 Skp1 Hsp90aa1 Pdk1 Fbl Ppp1r12a Unc5cl Ppp1r13l Usp2 Xiap Fbxw11 Txlna Ube2d3 Tank Relb Map3k3 Map3k2 Btrc Rxra Flna Papola Bag4 Ripk3 G3bp2 Cops3 Kpna6 Kpna3 Cdk9 Zbtb17 Cyba Ccnt1 Trap1 Bcl3 Tab3 Tab2 Traf7 Mcm7 Traf4 Pfdn2 Traf6 Traf5 Birc3 Jun Birc2 Ywhah Ywhag Psmd12 Copb2 Hdac2 Cav1 Smarcb1 Ywhab Psmd13 Alpl Rasal2 Rnf11 Hdac6 Iqgap2 Peg3 Bcl7a Ppp6c Nupr1 Rps6ka5 Mcm5 Smarca4 Cul1 Tnip2 Polr2h Tab1 Pdcd2 Junb Nsmaf Zfand5 Cflar Casp3 Romo1 Casp2 Trim32 Spag9 Usp11 Glb1 Smarcc2 Prc1 Smarcc1 Rnf25 Foxo1 Mtif2 Map2k6 Rb1 Pml Nfkbia Crebbp Grb2 Nfkb1 Pak1 Stat1 Mapk8 Map3k8 Hsp90ab1 Dok1 Ddx3x Sos2 Sos1 Ywhaz Src Ptpn11 Mapk14 Irs1 Egfr ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Lamc2 Ar Vim Akt1 Pik3r1 Ptk2 Mapk1 Prkca Mapk3 Shc1 Mtor Yes1 Abl1 Prkcd Trp73 Pik3cg Jun Ywhah Pik3ca Grb2 Ywhab Ywhaz Src Ptpn11 Mapk14 Casp3 Clca1 Erbb2 Rpsa Irs1 Irs2 Fos Rhoa Pak1 Rac1 Eif4ebp1 Plec Dsp Lama5 Cd151 Itgb4 Lama2 Lama3 Fyn Mst1r Pik3r2 Met Mylk3 Col17a1 Egfr Itga6 Eif4e Ntn1 Ephb2 Lamb2 Ywhae Lamb3 Gab1 Sfn Lamb1 Pik3cb Pik3cd Rtkn Bad Smad2 Erbin Smad3 Eif6 Lamc1 WNT%NETPATH%WNT Wnt Map3k7 Sox1 Ctbp1 Akt1 Wnt5a Cdh1 Setdb1 Pi4k2a Ppp1ca Prkcb Sfrp2 Ppp2ca Sfrp1 Daam1 Prkca Dkk1 Mesd Pax2 Prkcg Frzb Dixdc1 Chd7 Axin1 Ror1 Lef1 Lrp1 Yes1 Arhgef4 Csnk1a1 Nlk Lrp5 Prkcd Gpc3 Dvl3 Wnt2 Wnt1 Tcf7l2 Wnt3 Fzd1 Jup Fzd5 Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Smad1 Bcl9 Pin1 Tcf4 Nfatc2 Jun Ccnd1 Ywhab Pip5k1b Cdk6 Rhoa Rac1 Prkaca Mark2 Mapk8 Arrb2 IL6%NETPATH%IL6 IL6 Ar Rb1 Map3k7 Hdac1 Hspb1 Akt1 Pik3r1 Fgr Hck Mapk1 Mapk3 Shc1 Ep300 Hsp90aa1 Plcg1 Nlk Stat5a Prkcd Stat5b Btk Cdk9 Socs3 Lyn Map3k4 Pias3 Cd40 Tyk2 Sgk1 Il6st Hnrnpa1 Il6 Bmx Crebbp Eif2a Jun Map2k4 Il6ra Grb2 Nfkb1 Stat3 Cbl Erbb3 Gab2 Vav1 Ptpn11 Daxx Mapk14 Ptk2b Foxo4 Foxo3 Foxo1 Map2k2 Erbb2 Fos Rac1 Eif4ebp1 Gsk3b Fyn Jak1 Pik3r2 Map2k1 Eif4e Stat1 Mapk8 Gab1 Map2k6 Ncoa1 Bad TSH%NETPATH%TSH TSH Creb1 Tshr Hspa5 Canx Gnai2 Atp1a1 Gnai1 Scrib Calr Gnai3 Map2k3 Gnaq Mapk3 Raf1 Lep Map2k6 Igf1r Gna12 Gna11 Ikbkb Gna13 Gnao1 EGFR1%NETPATH%EGFR1 EGFR1 Tjp2 Cavin1 Cavin2 Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Stambp Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Ripk1 Sirpa Ralgds Dlg3 Crim1 Ddx6 Afap1l2 Tgif1 Sfpq Dapp1 Asap1 Iqgap1 Asap3 Anks1 Baiap2 Lsr Epn1 Rps6ka3 Dyrk4 Epn3 Usp31 Dyrk3 Dock4 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Rgs16 Kras Mta2 Snrpd2 Egf Spry2 Spry3 Spry1 Reps2 Spry4 Pebp1 Ptpn23 Zpr1 Map2k2 Appl1 Dyrk1a Creb1 Hdac1 Pik3r1 Ptk2 Mapk1 Myc Jund Dab2 Sp1 Jun Pik3ca Trp53 Cav1 Stk11 Pdpk1 Foxo4 Zfyve16 Foxo1 Fos Gsk3b Crk Pik3r2 Ap2b1 Map2k3 Pard3 Prkd1 Crkl Plcg1 Cblb Plcg2 Prkcd Itsn2 Vasp Arhgef7 Pttg1ip Lyn Tfrc Pik3c2b Kirrel1 Shb Dyrk1b Cltc Nfkb1 Pgam1 Vav1 Vav2 Ldha Prpf4b Pak1 Caskin2 Git2 Mpzl1 Map2k1 Nedd9 Mapk7 Mapk8 Erbin Sdcbp Rela Dok1 Dok2 Pkp4 Flnb Raf1 Abl1 Ptpra Cdk1 Ddx3x Acp1 Nck1 Adam9 Pkm Lck Ywhaz Ubash3b Atp1a1 Ptpn6 Cebpb Ptpn12 Mapk14 Arhgap35 Ptk2b Khdrbs1 Erbb2 Eif4ebp1 Prkaa1 Prkaa2 Fyn Jak1 Nos3 Sh2b1 Egfr Gsk3a Cdk5 Rps6ka2 Socs1 Jak2 Sh3kbp1 Rps6ka1 Kit Prkca Grb7 Mtor Stat5a Stat5b Cdk2 Hras Elk1 Pik3cg Ptpn18 Casp9 Erbb3 Gab1 Itch Mapk9 Map3k3 Ywhab Rps6ka5 Irs2 Rhoa Rac1 Plec Dsp Itgb4 Met Col17a1 Ephb2 Pik3cb Pik3cd Bad Smad2 Smad3 Vim Ctbp1 Cdh1 Prkcg Arhgef4 Jup Socs3 Map3k4 Pias3 Tyk2 Hnrnpa1 Scrib Il17rd Myl12b Mprip Elk4 Gja1 Tfg Ralb Otud6b Araf Frs2 Frs3 Arhgap5 Prkci S100a14 Arap1 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot1 Errfi1 Myo6 Garem1 mt-Co2 Antxr1 Arf4 Braf Clta Cyld Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl2 EG433182 Stx4 Inppl1 Pygb Pdzd11 Gsn Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Ensa Stat2 Pkn2 Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Atxn2 Grb14 Rictor Grb10 Phpt1 Stip1 Cdh3 Cdh2 Plekhn1 Cfl1 Magi1 Hat1 Pkp2 Hnrnpdl Anxa4 Ldlr Pkp3 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Serpinb3d Abl2 Slc38a2 Ptpre Tnk2 Alb Bcl2 Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Sh3gl3 Epha1 Epha2 Epha4 Itgb1 Dsg2 Ctnnal1 Cd59b Wbp2 Sri Ephb1 Cebpa Ephb3 Ephb4 Ahcyl1 Ptpn1 Slitrk6 Csk Arhgap32 Rbbp7 Tagln2 Pten Ralbp1 Bcar3 Slc25a5 Arhgap42 App Spart Nectin1 Rps10 Tns4 Scamp3 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Pfn1 Tln1 Rin1 H3c8 Hnrnpr Sdc4 Sdc3 Insr Stam Atp5f1c Usp6nl Slc5a5 Snx5 Tollip Pdcd6ip Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Ptprk Ptprf Dcbld2 Rps27l Git1 Cdv3 Laptm4a Plekha6 Plekha5 Mink1 Actn1 Actn4 Plscr1 Gprc5a Map2k7 Aldoa Ncoa3 Limd1 Cstb Krt18 Krt17 Racgap1 Wasl Cttn Axl Ctnnd1 Huwe1 ID%NETPATH%ID ID Psmd4 Map2k2 Rb1 Fhl2 Tcf7l2 Pax5 Elk1 Elk3 Rbl1 Hes1 Atf3 Id3 Smurf2 Rbl2 Tcf3 Myf5 Mapk1 Elk4 Map2k1 Mapk3 Raf1 Smad3 Cdk2 IL9%NETPATH%IL9 IL9 Mapk3 Tyk2 Kat5 Stat6 Mapk1 Stat5a Il9r Stat5b IL3%NETPATH%IL3 IL3 Creb1 Ywhab Ywhaz Pik3r1 Nfkb1 Ptk2 Ptpn6 Dok1 Prkcb Mapk1 Ppp2ca Socs2 Prkca Bcl2l11 Kcnip3 Rara Gab2 Slc2a1 Inpp5d Gata2 Shc1 Crkl Csf2rb2 Ptprc Fes Foxo1 Hras Rxra Gsk3b Crk Pik3r2 Map2k1 Socs3 Lyn Prkaca Gsk3a Gab1 Bcl2l1 Rack1 Pik3cd Bad IL5%NETPATH%IL5 IL5 Ywhaz Nfkb1 Bax Atf2 Stat3 Hck Cbl Rps6ka1 Syk Raf1 Shc1 Alox5 Ptpn11 Il2rb Pla2g4a Crkl Mapk14 Il5 Sox4 Ptk2b Il5ra Stat5a Stat5b Prkcd Foxo3 Map2k2 Hras Elk1 Unc119 Gsk3b Jak1 Lyn Rapgef1 Ctnnb1 Pik3cg Stat1 Gsk3a Nfkbia Dnm2 Rack1 Jun Socs1 Hcls1 Grb2 Sdcbp Sos1 IL4%NETPATH%IL4 IL4 Akt1 Jak2 Ptk2 Atf2 Mapk1 Ets1 Mapk3 Inpp5d Shc1 Ep300 Plcg2 Prkcd Elk1 Rasa1 Cebpa Cd40 Tyk2 Nfkbia Crebbp Pik3ca Ikbkb Nfkb1 Ptpn6 Stat3 Cbl Cebpb Syk H3c8 Ptpn11 Mapk14 Stam Spi1 Il13 Cxcr4 Il13ra1 Snd1 Il4 Chuk Grk3 Il2rg Mapk11 H3c7 Irs2 Jak1 Ncoa3 Mapk8 Pik3cd Bad Socs1 IL-7%NETPATH%IL-7 IL-7 Akt1 Pik3r1 Stat3 Jak3 Mapk1 Il7r Mapk3 Shc1 Stam Cblb Stat5a Stat5b Foxo3 Foxo1 Map2k2 Il2rg Il7 Irs1 Irs2 Gsk3b Fyn Map2k1 Stat1 Gsk3a Bad NOTCH%NETPATH%NOTCH Notch Kat2b Akt1 Jak2 Pik3r1 Rela Mapk1 Mapk3 Ep300 Skp1 Lef1 Rbx1 Smad1 App Hdac2 Src Hes1 Nfkb1 Stat3 Tcf3 Cul1 Sin3a Fhl1 Mfng Ccn3 Skp2 Gsk3b Sap30 Hes6 Maml3 Notch4 Notch2 Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Dll3 Dll4 Maml1 Ring1 Maml2 Furin Fbxw7 Jag2 Cirsr Rbpj Yy1 Smad3 Lfng IL2%NETPATH%IL2 IL2 Stat4 Creb1 Il2ra Ybx1 Ets2 Plcb1 Akt1 Tert Pik3r1 Nr3c1 Atf2 Rela Itm2b Ccne1 Eif3b Il2 Prkcz Mapk1 Nmi Vil1 Mknk1 Ets1 Mapk3 Raf1 Shc1 Mtor Crkl Hsp90aa1 Stat5a Stat5b Cdk2 Bcl2 Elk1 Socs3 Lyn Pik3cg Stam2 Sgk1 Jun Lck Pik3ca Grb2 Sos1 Shb Nfkb1 Ptpn6 Jak3 Cbl Gab2 Vav1 Ptpn11 Il2rb Mapk14 Stam Ptk2b Foxo3 Map2k2 Il2rg Irs1 Irs2 Eif4ebp1 Crk Fyn Jak1 Pik3r2 Map2k1 Eif4e Mapk8 Pik3cb Pik3cd Il15 TSLP%NETPATH%TSLP TSLP Stat4 Relb Akt1 Nfkb1 Rela Stat3 Stat6 Mapk1 Map2k1 Nfkb2 Mapk9 Mapk3 Eif4e Stat1 Mapk14 Mapk8 Nfkbia Stat5a Stat5b RANKL%NETPATH%RANKL RANKL Map3k7 Ptk2 Nfkb1 Rel Nfkb2 Traf3 Tnfsf11 Atp6v1e1 Tab1 Sqstm1 Tab2 Tnfrsf11b Trem2 Mapk14 Traf2 Mapk8 Traf1 Traf6 Traf5 Spi1 Mitf Chuk IL1%NETPATH%IL1 IL1 Rb1 Akt1 Pik3r1 Nfkb1 Atf2 Rela Map2k3 Dok1 Ppp6c Elp1 Mapk1 Mapk9 Mapk3 Tab1 Pla2g4a Mapk14 Peli1 Ube2v1 Ube2n Irak4 Irak3 Irak2 Irak1 Tollip Myd88 Chuk Il1a Fbxw5 Il1b Map3k2 Peli2 Il1r2 Il1r1 Il1rn Rel Pik3r2 Tab3 Tab2 Mapk8 Traf6 Nfkbia Map2k6 Jun Ikbkb Map3k14 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Hacl2 Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Rpia Gpi Taldo1 Hkdc1 Pgd Tkt Hk2 Hk1 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation Faah FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Mthfd2 Dhfr Mthfd1l Tyms Mtr FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Gale Galt Aldob Aldoc Aldoa Hkdc1 Khk Hk2 Hk1 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Tab1 Mapk11 Traf6 Srf Mef2d Elk1 Map3k7 Map2k6 Map3k4 Hspb1 Mapk12 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Cryaa Rac2 Kdr Akt1 Rac3 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Pik3ca INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Nos3 Il10 Ikbkb Il11 Mapk7 Spi1 Il15 Irs1 Cxcr1 Stat6 Cxcr2 Stat4 Il13 Il18 Il2ra Il2rb Irs2 Il15ra Mapk6 Sla2 Elk3 Elk4 Pdpk1 Akt3 Myc Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Il20ra Fos Il23a Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Il5ra Sos2 Sos1 Il6st Shc1 Il10rb Il3ra Mtor Il2 Il4 Srf Il6 Il5 Elk1 Il7 Il9 Il21 Il12rb1 Mapk15 Il12rb2 Spic Il1a Stat5a Mapkapk2 Stat5b Il6ra Il4ra Stat3 Stat2 Stat1 Chuk Mknk2 Cdkn1a Mknk1 Cdkn1b Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 Pik3cb Pik3ca FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis Flad1 Rfk HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Rsad1 Hmbs Fech Eprs1 Cpox Urod Ppox Ears2 Cox10 Alad Qars1 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Cacna1g Cacna1c Chrnb4 Epb41l2 Kcnk3 Chrnb3 Clic6 Ppp1r1b Chrnb2 Gng2 Slc18a2 Adcy2 Drd2 Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Gnb1 Chrna4 Flna Gnai1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Sqle Fdps Mvk Pmvk Ggps1 Hmgcr Mvd Pdss1 Fdft1 Lss IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Grm2 Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc17a8 Slc1a6 Slc17a6 Vamp8 Vamp1 Gria4 Vamp3 Vamp2 Gria3 Snap29 Gria2 Snap25 Gria1 Grik5 Snap23 Stx19 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Stx11 Grin2b Grin2a Shank1 Shank3 Grm3 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 Pnpo CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Rpa3 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Mapk13 Mapk14 Pik3c2b Pik3c2a Hras Cdkn1a Mapk11 Pik3c3 Pdpk1 Akt3 Akt1 Akt2 Ccne1 Ccng1 Ctnnb1 Trp63 Kras Rb1 Ppp2cb Nras Ppp2ca Trp53 Tpte Pten Pik3c2g Rbl1 Cdk2 Pik3r5 Siah1a Pik3r1 Atm Pik3r2 Trp73 Pik3cg Pik3cb Pik3cd Mapk12 Pik3ca THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Plcb1 Hrh1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Gng12 Itpr2 Itpr1 Gng2 Plcg1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Gnb1 Prkce Prkca Plcb4 Plcb3 Gna11 Gng10 Gna14 Prkcz Plcd1 Plcb2 Plcd4 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Grin1 Gnaq Prkaca Prkcb Itpr1 Prkar1a Prkar1b Grik5 Prkx Prkacb Grina Grm1 Grik1 Plcb4 Grm5 Homer1 Gna11 Grin2d Grin2c Grin2a Grin2b OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Map2k3 Myc Mapk13 Bcl2 Mapk14 Eef2k Map2k4 Stat1 Mef2c Mknk2 Mknk1 Mapk11 Pla2g4a Mapk9 Elk1 Jun Mapk8 Map2k6 Ddit3 Max Mapk12 Txn 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Kcnk3 Gnao1 Gng2 Adcy7 Adcy2 Prkar2a Prkar2b Htr1d Htr1f Prkaca Gnai2 Kcnk9 Htr1b Htr1a Gng11 Gnai3 Gnb1 Gnai1 Gng10 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Gng2 Plcg1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Oxtr Prkcd Gnb1 Prkce Prkca Plcb4 Plcb3 Gna11 Gng10 Gna14 Prkcz Plcd1 Plcb2 Plcd4 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Gng3 Gng2 Gng4 Adcy7 Gng7 Adcy2 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Htr4 Gnb1 Gnal Gng12 Gng10 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Prkar1a Prkar1b Prkacb Cacna1g Gnao1 Adcy7 Adcy2 Prkar2a Prkar2b Prkaca Gng11 Gnai3 Gnb1 Cacna1a Cacna1b Gnai1 Gabbr1 Gabbr2 Adcy4 Adcy1 Adcy8 Adcy5 Adcy6 Adcy9 Kcnj3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2e3 Uba3 Ube2d1 Ube2e2 Ube2e1 Ube2g2 Ube2l6 Ube2g1 Ube2a Atg7 Sae1 Ube2l3 Ube2t Ube2v2 Ube2k Uba6 Uba7 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway App Erbb4 Apbb2 Nectin1 Apbb3 Trpc6 Afdn Trpc5 Cdh3 Trpc7 Kat5 Wnt5a Cdh1 Trpc1 Trpc4 Wnt5b Wnt9a Kat7 Wnt9b Fzd10 Ctnnb1 Wnt10a Bace2 Wnt10b Bace1 Acta1 Gsk3b Acta2 Actb Actr2 Notch4 Ern1 Notch1 Notch2 Notch3 Psen1 Wnt8b Wnt8a Psen2 Fstl1 Lrp1b Wnt16 Wnt11 Lef1 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Cd44 Actg1 Tcf7l2 Wnt3 Fzd1 Actbl2 Fzd3 Actc1 Fzd2 Trim3 Jup Fzd5 Trim2 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Rbpj Wnt2b 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh1b1 Maoa Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh4a1 Aldh1a3 Aldh2 Aldh3a1 Aldh16a1 Aldh8a1 Aldh7a1 Aldh9a1 Il4i1 Aldh1l1 Aldh1l2 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm2 Mdm4 Trp73 Cop1 Trp63 Trp53 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Hacl2 Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss2 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Pank3 Pank2 Pank4 Ppcs Pank1 Dcakd METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Aco1 Ireb2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Nfkbil1 Cd22 Vav3 Syk Vav1 Map2k2 Vav2 Map3k3 Map2k1 Map3k2 Hras Blnk Ikbkb Btk Cd79a Cd79b Ptpn6 Lyn Ptprc Ppp3ca Ppp3cb Nfkbia Cd19 Grb2 Mapk10 Fos Sos2 Sos1 Mapk12 Mapk13 Mapk14 Chuk Itpr3 Itpr2 Mapk11 Itpr1 Mapk1 Mapk9 Mapk3 Jun Mapk8 Rac2 Rac1 Araf Plcg2 Nras Prkcb Prkcd Raf1 Pik3cg Pik3cb Pik3cd Pik3ca P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Akt2 Trp63 Ppp2cb Ppp2ca Trp53 Trp73 Eif4ebp1 Tsc2 Tsc1 Igbp1 Prkaa1 Prkab2 Prkaa2 Rps6kb2 Prkab1 Akt3 Akt1 Prkag1 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Liph Plcb1 Dagla Lpl Pla1a Plcb3 Plcb2 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppa Pmm2 Gmds Mpi Gmppb Pmm1 MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrnp40 Zrsr2 Prpf3 Snrpb2 Snrpa HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Akt2 Rorc Arnt Txn2 Crebbp Egln2 Egln3 Mtor Vhl Hif1a Txn Akt3 Akt1 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Polr2e Creb3l1 Polr2f Ttf2 Creb3l2 Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Gtf2h4 Psmc3ip Gtf2f2 Gtf2h3 Gtf2f1 Brf2 Tbp Brf1 Prkar1a Tbpl2 Prkar1b Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Gtf2e1 Taf4 Taf2 Gtf2e2 Prkar2a Prkar2b Crebbp Gtf2a1l Polr2c Taf1c Taf9 Ep300 Creb3l3 Polr2h Creb3l4 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Oprd1 Pomc Gnao1 Gng3 Gng2 Gng4 Adcy7 Gng7 Adcy2 Gng8 Gngt2 Gnai2 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 Gnb1 Gng12 Gnai1 Gng10 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b10 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 Glul UNTITLED%PANTHER PATHWAY%P00019 untitled Nos3 Map2k2 Map2k1 Akt3 Akt2 Plcb4 Plcb3 Gna11 Gna14 Plcb2 Plcb1 Gnaq Itpr3 Itpr2 Itpr1 Prkar1a Mapk1 Prkar1b Pla2g4a Prkacb Mapk3 Akt1 Adcy7 Adcy2 Araf Prkar2a Prkcq Prkar2b Prkcg Prkaca Prkch Prkci Ednrb Prkcb Ednra Adcy3 Edn1 Prkcd Edn2 Gnal Edn3 Prkce Prkca Adcy10 Raf1 Gucy1b1 Prkg2 Adcy4 Prkg1 Adcy1 Gucy1a1 Adcy8 Gucy1a2 Adcy5 Adcy6 Adcy9 Prkcz HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Gch1 Fpgs Dhfr Tyms 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Gng2 Plcg1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Gng11 Prkcd Gnb1 Prkce Prkca Plcb4 Plcb3 Gna11 Htr2a Gng10 Htr2c Gna14 Htr2b Prkcz Plcd1 Plcb2 Plcd4 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Map3k3 Map3k2 Mapk10 Map3k4 Mapk13 Map2k4 Braf Pik3c3 Mapk9 Mapk3 Mapk8 Rac2 Map2k3 Rac1 Araf Nras Raf1 Pik3r1 Pik3r2 Pxn Pik3cg Col14a1 Pik3cb Map3k5 Pik3cd Itgbl1 Pik3ca Crkl Arfgap1 Col10a1 Pik3c2b Col1a2 Pik3c2a Col5a2 Ptk2 Col5a3 Map2k2 Dmbt1 Col5a1 Map2k1 Col9a2 Hras Col9a3 Col9a1 Arpc1b Lama5 Arpc1a Lama1 Lama2 Lama3 Lama4 Flnb Tln1 Vcl Vasp Col17a1 Col13a1 Fn1 Itga7 Mapk6 Arl1 Itga8 Itga5 Itga6 Itga9 Itga3 Itga4 Elmo2 Itga1 Itga2 Elmo1 Itga10 Itga11 Col4a3 Col4a4 Arpc3 Col4a1 Cav1 Actb Arpc2 Col4a2 Col8a1 Col4a5 Sos2 Col8a2 Sos1 Col4a6 Shc1 Arpc5 Parvb Parva Rap2b Col16a1 Rap2a Arf1 Rap2c Col12a1 Itgax Ilk Itgav Rnd2 Rhoc Rnd3 Rhoa Rnd1 Rhob Itgam Asap1 Itgae Itgal Arhgap10 Rap1a Col3a1 Rap1b Itgad Itgb8 Itgb6 Itgb7 Actg1 Itgb1 Itga2b Itgb4 Rras Actn2 Actbl2 Itgb5 Itgb2 Actn1 Col20a1 Actn4 Crk Arf6 Arpc5l Arhgap26 Col15a1 Col11a1 Col11a2 Src Ntn4 Dock1 Bcar1 Dnajc27 Lamb2 Lamb3 Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Col6a1 Col6a2 Flna Ptk2b Col6a3 Lims2 Lamc3 Rapgef1 Lamc1 Lamc2 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Arhgap9 Shc3 Rasa2 Rasa1 Vav3 Rasa4 Pdgfrb Vav1 Pdgfra Vav2 Pdgfa Map3k2 Pdgfrl Pdgfb Grap Fli1 Rps6kc1 Fev Gabpa Nck2 Jak2 Jak1 Nck1 Arhgap15 Grb2 Arhgap12 Gab1 Mapk10 Gab2 Etv3 Spdef Elf1 Elf2 Gsk3a Elf3 Rps6kb2 Elf4 Elf5 Ophn1 Mycbp Usf2 Grap2 Elp1 Rerg Nin Pkn2 Ninl Arhgap42 Pik3r5 Srf Elk1 Map3k4 Mapkapk2 Rps6ka4 Rps6ka5 Mknk2 Mknk1 Itpr3 Itpr2 Itpr1 Mapk1 Braf Ets1 Pik3c3 Mapk3 Jun Mapk8 Plcg1 Araf Plcg2 Nras Arhgap1 Prkca Raf1 Pik3r1 Pik3r2 Arhgap8 Shc2 Pik3cg Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Hras Ikbkb Mapk7 Stat6 Stat4 Mapk6 Elk4 Pdpk1 Myc Akt2 Jak3 Fos Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Shc1 Mapk15 Stat5a Stat5b Stat3 Stat2 Arhgap10 Stat1 Chuk Arhgap26 Ehf Srgap1 Srgap3 Rab11b Arhgap6 Arhgap5 Arhgap4 Erf Erg NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Slc44a3 Actr1a Acta1 Myo3a Acta2 Actr1b Actb Myo3b Chrnb1 Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh1 Myh2 Myh3 Myh15 Myh8 Myh9 Myh4 Myh6 Myh7 Myo1c Myo1b Myo1e Myo1d Myo5c Myo5b Myo1a Myh11 Myh14 Myh13 Myo1g Myo1f Plekhh3 Myh10 Myo18a Myo6 Myo18b Myo5a Myo9a Actg1 Slc5a7 Chrnd Chrne Chrng Actbl2 Chrna2 Chrna1 Actc1 Myo10 Chrna9 Myo15a Myo16 Chrnb4 Chrnb3 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Jak2 Stat6 Jak1 Stat5a Jak3 Stat5b Stat4 Stat3 Stat1 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism Sugct SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Phgdh Psph Psat1 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Pik3c2b Pik3c2a Vasp Ntn1 Rac2 Ntn3 Nfatc4 Rhou Rac1 Nfatc3 Ntn4 Nfatc2 Ablim1 Plcg1 Dcc Ntng1 Plcg2 Unc5b Unc5d Unc5c Pik3r5 Pik3r1 Pik3r2 Pik3cg Pik3cb Pik3cd Pik3ca ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc6a2 Slc6a3 Slc18a2 Slc6a19 Slc6a18 Slc6a15 Slc6a17 Slc6a20a Slc6a16 Slc18a1 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Fmo3 Ugt1a2 Cyp2a5 Inmt Ugt1a5 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism Sugct S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mat2a Mat1a Mtr CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Pfn1 Mylk3 Pfn3 Pfn2 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Pak5 Arpc1b Pak4 Tubb5 Arpc1a Tubb6 Tubb3 Tubb1 Wasl Mylk Limk1 Arpc4 Rock2 Tubb4b Rock1 Tubb4a Arpc3 Acta1 Myo3a Acta2 Actb Arpc2 Myo3b Arpc5 Myh1 Myh2 Myh3 Myh8 Myh9 Myh4 Myh6 Myh7 Rhoc Myh11 Myh14 Myh13 Myh10 Actg1 Actbl2 Actc1 Rac2 Rhou Rac1 Diaph2 Diaph1 Tubb2b Tubb2a Cfl1 Cfl2 Mylk2 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Rasa1 Map2k2 Rps6ka4 Map2k1 Rps6ka5 Irs1 Mapk1 Ins2 Irs2 Insr Irs4 Mapk3 Igf2r Igf2 Rps6kb2 Igf1 Insrr Igf1r Map2k3 Fos Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Raf1 Elk1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Ifng Jak2 Ifngr2 Jak1 Ifngr1 Stat1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Upp1 Upp2 Uprt Nme3 Nme2 Nme4 Uck1 Uck2 Uckl1 Adat2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc1a6 Vamp8 Vamp1 Gria4 Vamp3 Vamp2 Gria3 Snap29 Gria2 Snap25 Gria1 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Cacna1e Grm4 Grm7 Grm8 Vti1a Stx1b Cacnb1 Stx1a Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkar1a Prkar1b Prkx Prkacb Grm1 Grm5 Prkar2a Prkar2b Prkaca Gnai2 Gnai3 Gnb1 Cacna1a Cacna1b Gnai1 Adcy10 Grin2a APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Casp9 Ikbkb Nfkbia Mapk10 Igf2r Akt3 Akt2 Fos Trp53 Atf2 Eif2ak2 Birc3 Birc2 Tnf Madd Bcl2l11 Tnfrsf1b Tnfrsf1a Tradd Nfkb2 Nfkb1 Traf2 Bcl2l1 Xiap Map2k4 Endog Tnfsf10 Rela Chuk Relb Map3k1 Apaf1 Tnfrsf10b Lta Fadd Atf7 Ltb Atf6 Mapk1 Atf4 Atf3 Jdp2 Aifm1 Gzmb Map2k7 Gzmf Mapk9 Mapk3 Map4k4 Map4k3 Jun Mapk8 Fasl Atf6b Cradd Akt1 Bak1 Eif2s1 Map2k3 Casp8 Bcl2 Casp7 Prkra Casp3 Prkcq Bik Ripk1 Prkcg Map4k2 Prkch Diablo Bax Rel Prkcb Fas Daxx Map3k14 Prkcd Prkce Prkca Pik3cg Pik3cb Map3k5 Pik3cd Pik3ca LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Pak1 Map2k2 Map2k1 Pak3 Hras Pak2 Grb2 Mapk10 Gsk3a Pdpk1 Akt3 Kras Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Shc1 Atf2 Srf Elk1 Map2k6 Map3k4 Rhoc Mapk12 Mapkapk3 Rhoa Mapk13 Mapk14 Rhob Mapkapk2 Map2k4 Stat3 Stat1 Map3k1 Mapk11 Mapk1 Braf Ets1 Map2k7 Pik3c3 Mapk9 Mapk3 Jun Mapk8 Rac2 Akt1 Rac3 Map2k3 Rac1 Araf Nras Tiam1 Rala Ralb Exoc2 Raf1 Pld1 Pld2 Ralgds Rgl1 Pik3cg Pik3cb Pik3cd Pik3ca ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Plcb1 Gng3 Gng4 Gng7 Gnaq Map2k2 Gng8 Gngt2 Map2k1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Mapk1 Mapk3 Gng11 Gnb1 Prkca Raf1 Grk3 Grk2 Agtr1a Plcb3 Arrb2 Elk1 Arrb1 Gng10 Egr1 Agt Plcb2 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Polr2f Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Gtf2h4 Gtf2f2 Gtf2h3 Gtf2f1 Brf2 Brf1 Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Gtf2e1 Taf4 Taf2 Gtf2e2 Gtf2a1l Polr2c Taf1c Taf9 Polr2h P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Chek2 Gadd45b Gadd45a Wrn Hdac1 Traf2 Sfn Cdkn2a Mta2 Kat2b Gtse1 Pml Cdkn1a Cdk1 Sirt1 Cdc25c Pdpk1 Akt3 Akt1 Akt2 Ccne1 Trp63 Trp53 Tpte Pten Cdk2 Crebbp Mdm2 Atm Mdm4 Trp73 Ep300 Gadd45g Sin3a Sumo3 Pik3ca THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Vamp8 Vamp1 Vamp3 Vamp2 Trh Trhr Snap29 Stx3 Cga Snap25 Cacnb3 Cacnb4 Cacnb2 Snap23 Tshb Cacna1e Cacnb1 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Gng2 Plcg1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Gnb1 Cacna1a Prkce Cacna1b Prkca Prkcz ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b7 Hsd17b6 Hsd17b3 Soat2 Soat1 Hsd17b1 Hsd17b2 Lipa Cyp19a1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Ctnnb1 Cdh6 Pcdhgb6 Pcdhgb7 Cdh5 Cdh4 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Pcdh11x Cdh17 Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhgb1 Pcdhga5 Pcdhga6 Pcdhga7 Pcdhga8 Ctnnd2 Pcdhga1 Ctnnd1 Pcdhga2 Pcdhga3 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Acta1 Acta2 Actb Actr2 Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Wnt6 Wnt7b Wnt3a Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Actg1 Tcf7l2 Wnt3 Fzd1 Actbl2 Fzd3 Actc1 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b UNTITLED%PANTHER PATHWAY%P06664 untitled Tgif1 Skil Rela PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc2 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Pdha2 Suclg1 Mdh1 Ogdh Aco2 Sdhc Pdk2 Cs Fh Pdha1 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin2 Azin1 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 Mmut LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Dpysl2 Dpysl3 Cda Upb1 Nt5e Dpysl5 Aldh6a1 Dpys Abat Dpyd ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Gng3 Gng2 Gng4 Adcy7 Prkar2a Gng7 Adcy2 Prkar2b Gng8 Gngt2 Prkaca Gnb2 Gnb4 Gnb3 Gnb5 Gnb1 Gnal Gng12 Prkx Prkacb Adrb1 Gng10 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Foxo3 Gsk3b Tpte Pten Irs1 Mdm2 Mdm4 Tsc2 Ins2 Tsc1 Irs2 Insr Irs4 Gsk3a Igf2r Foxo1 Igf2 Igf1 Pdpk1 Insrr Pik3ca Igf1r HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gng3 Gng2 Gng4 Adcy7 Prkar2a Gng7 Adcy2 Prkar2b Gng8 Gngt2 Prkaca Gnb2 Gnb4 Gnb3 Gnb5 Gnb1 Gnal Gng12 Prkx Prkacb Gng10 Hrh2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gng3 Gng2 Gng4 Adcy7 Gng7 Adcy2 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gnb1 Gnal Gng12 Gng10 Adrb3 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Xdh Nt5e Ampd3 Gda METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Pomc Crh Gng3 Gng2 Crhr2 Gng4 Crhr1 Gng7 Gnaq Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gnb1 Gnal Gng12 Gna11 Gng10 Gna14 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Mapk13 Mapk14 Mapk7 Mapk11 App Mapk1 Cacnb2 Mapk10 Mapk9 Cacna1c Mapk6 Mapk3 Mapk8 Kat5 Cacna1f Cacna1d Prkcq Pkn3 Pkn2 Klc1 Bace2 Prkcg Adam17 Prkch Mapk4 Bace1 Prkci Klc4 Klc3 Prkcb Klc2 Cacna1s Apba1 Prkcd Apba2 Apba3 Prkce Prkca Pkn1 Psen1 Cacnb1 Psen2 Ncstn Prkcz Aph1b Mapk15 Mapk12 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Rac1 Ntn4 Dcc Ntng1 Cxcl12 Slit1 Slit2 Slit3 Robo1 Srgap1 Cxcr4 Abl1 Ntn1 Rac2 Ntn3 Rhoc DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Nme1 Nme3 Dscaml1 Nme2 Dhodh Nme4 Cad Ctps2 Ctps1 Cps1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Shc3 Rasa2 Pik3c2b Rasa1 Pik3c2a Rasa4 Map2k2 Map3k3 Map2k1 Map3k2 Hras Grap Stat6 Erbb4 Stat4 Gab1 Mapk10 Gab2 Akt3 Akt2 Sos2 Sos1 Pik3r5 Shc1 Map2k6 Map3k4 Mapk12 Erbb2 Mapk13 Erbb3 Mapk14 Stat5a Mras Stat5b Rasal2 Gab3 Egfr Map2k4 Stat3 Phldb2 Stat2 Nf1 Stat1 Rras2 Dab2ip Pebp4 Spry2 Spry3 Spry1 Spry4 Pebp1 Mapk11 Prkd3 Mapk1 Rras Prkd1 Braf Prkd2 Map2k7 Pik3c3 Mapk9 Mapk3 Mapk8 Rac2 Akt1 Map2k3 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Prkcd Prkce Prkca Raf1 Shc2 Pik3cg Prkcz Pik3cb Map3k5 Pik3cd Pik3ca PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Fgb Fga Mmp13 Fgg Mmp3 Plat Plg Mmp9 Mmp1a Plau Serpine1 Serpinf2 Plaur Serpinb2 PNAT%PANTHER PATHWAY%P05912 PNAT Gng3 Gng4 Gng8 Vamp8 Vamp1 Gnb2 Gnb4 Vamp3 Gnb3 Vamp2 Snap29 Stx3 Snap25 Prkx Snap23 Prkacb Epb41l2 Kcnk3 Epb41l3 Clic6 Ppp1r1b Drd1 Drd5 Ppp1cc Slc18a2 Adcy7 Gnaz Adcy2 Prkar2a Drd2 Prkar2b Drd4 Ppp1ca Prkaca Gnai2 Kcnk9 Epb41 Gng11 Gnai3 Gnb1 Flna Slc6a3 Gnai1 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Crebbp Shh Smo Ptch1 Sufu Fbxw11 Btrc Gli1 Gli3 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Slc5a7 Prkar1a Prkar1b Prkx Prkacb Gnao1 Prkar2a Prkar2b Prkaca Gnai2 Gng11 Kcnj9 Gnai3 Kcnj6 Kcnj5 Gnb1 Chrm2 Chrm4 Slc18a3 Adcy10 Gnat2 Gnai1 Slc6a8 Gnat1 Kcnj3 Gng10 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Gnpda1 Amdhd2 Gfpt1 Gnpda2 Gfpt2 Npl TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Jund Acvr1c Snip1 Lefty1 Tgfb2 Tgfb3 Gdnf Cited1 Acvrl1 Hras Cited2 Acvr1b Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Bmpr1b Gdf3 Gdf6 Bmp7 Gdf5 Bmp6 Mapk10 Bmp5 Gdf7 Bmp4 Bmpr2 Smad1 Bmp3 Smad2 Gdf9 Nodal Bmp2 Smad3 Smad4 Bmp1 Smad9 Acvr2a Tll2 Gdf15 Inhba Tll1 Inhbb Acvr2b Inhbc Tgfbr1 Smad5 Junb Tgfbr2 Smad6 Smad7 Crebbp Gdf11 Inhbe Gdf10 Atf2 Map3k7 Ep300 Mapk12 Mapk13 Mapk14 Tab1 Mapk11 Mapk1 Rras Mapk9 Mapk3 Jun Mapk8 Nras Bmp10 Bmp8a Bmp15 Skil Dcp1b Lefty2 Acvr1 Foxh1 Smurf2 Smurf1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation F10 F12 Proz Tfpi F2 Serpina10 F3 Thbd F7 F8 F9 Pros1 F2rl3 Fgb Itga2b Fga Fgg Plat Plg Plau Plaur F2r Klkb1 Kng2 Gp5 Proc Gp9 Gp1bb F13b Gp1ba Procr Vwf PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Casp9 Nos3 Gnaq Gngt2 Gnb2 Gnb4 Gnb3 Ptger1 Gnb5 Foxo4 Irs1 Gngt1 Ywhaz Insr Foxo1 Rps6kb2 Pdpk1 Akt3 Akt1 Akt2 Foxo3 Gnai2 Gsk3b Nras Gnai3 Gnb1 Sos2 Sos1 Gnat2 Gnai1 Pik3r5 Pik3r1 Pik3r2 Gna11 Gna14 Pik3cb Pik3ca HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Grm2 Gsk3a Crebbp Gng10 Ep300 Creb3l3 Creb3l4 Creb3l1 Hrh1 Gng3 Gng4 Creb3l2 Gng7 Gng8 Gngt2 Gnb2 Gngt1 Gng12 Adora2b Adora2a Prkar1a Adra2c Prkar1b Adra2b Htr6 Prkacb Htr7 Oprl1 Grm1 Phka1 Grm5 Phka2 Adrb2 Adra1b Adra1a Adra1d Sstr5 Sstr4 Oprd1 Sstr3 Sstr2 Sstr1 Oprm1 Adcy7 Htr5a Prkar2a Phkb Prkar2b Chrm1 Htr1d Chrm3 Htr1f Chrm5 Gnai2 Hrh4 Htr1b Hrh3 Htr1a Adora1 Adora3 Gnai3 Gnrhr Adcy3 Htr4 Gys1 Gnal Gys2 Clta Cltb Cltc Mtnr1a Adcy4 Creb1 Adcy1 Creb3 Adcy8 Phkg1 Adcy5 Phkg2 Adcy6 Mtnr1b Adcy9 Pygb Kcnj3 Htr2a Pygl Htr2c Pygm Htr2b Gpr50 Oprk1 Adrb1 Hrh2 Adrb3 Gsk3b Grm4 Grm7 Grm8 Rap1a Rap1b Drd1 Drd5 Gng2 Adcy2 Drd2 Drd4 Prkaca Kcnj9 Kcnj6 Gnb1 Kcnj5 Chrm2 Chrm4 Gnai1 Grm3 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Frs3 Shc3 Fgfr3 Rasa2 Pik3c2b Fgfr4 Rasa1 Pik3c2a Fgfr1 Rasa4 Fgfr2 Map2k2 Map3k3 Map2k1 Map3k2 Hras Grap Ptpn6 Mapk10 Akt3 Akt2 Sos2 Sos1 Shc1 Map2k6 Map3k4 Mapk12 Mapk13 Mapk14 Map2k4 Spry2 Spry3 Spry1 Spry4 Pebp1 Mapk11 Mapk1 Map2k7 Pik3c3 Mapk9 Mapk3 Mapk8 Rac2 Akt1 Map2k3 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Prkcd Prkce Prkca Raf1 Pik3cg Prkcz Pik3cb Map3k6 Map3k5 Pik3cd Frs2 Pik3ca ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Asl Nags Otc Ass1 Cad Cps1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gng3 Gng4 Gng7 Gng8 Gngt2 Cnga3 Pdc Gnb2 Cnga1 Gnb4 Grk1 Pde6g Gnb5 Calml3 Rho Gngt1 Gng12 Rgs9 Pde6a Pde6b Cngb3 Rcvrn Gng13 Gng2 Gnb1 Gnat1 Gng10 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Mapk14 Sfn Mapk7 Ywhaz Mapk1 Mapk10 Psma4 Psma3 Psma6 Psma5 Mapk9 Ccne2 Mapk3 Psma2 Mapk8 Psma1 Cask Ywhah Ywhag Ywhae Th Ccne1 Ywhab Psmb10 Sncaip Psmb7 Prkn Psmb1 Gpr37l1 Septin5 Septin4 Psmb3 Stx7 Septin2 Septin1 Stx12 Gpr37 Slc6a3 Ndufv2 Psma7 Pld2 Snca Elk1 Mapk15 Mapk12 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Gng3 Gng4 Gng7 Grin1 Gnaq Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Slc5a7 Itpr2 Itpr1 Grin2d Grin2c Grin2b Prkcq Pkn3 Chrm1 Pkn2 Chrm3 Prkcg Prkch Prkci Prkcb Gng11 Prkcd Gnb1 Slc18a3 Prkce Prkca Pkn1 Plcb4 Gna11 Gng10 Grin2a Gna14 Prkcz OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Oprd1 Gng3 Gng2 Gng4 Adcy7 Gng7 Adcy2 Gng8 Gngt2 Gnai2 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 Gnb1 Gng12 Gnai1 Pdyn Penk Gng10 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Rpa2 Top2b Prim1 Top2a Dna2 Top1 H3-3b Rfc5 Pold2 Pold1 H3c8 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pola1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Mcee Pcca Pccb Mmut DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Nme1 Rrm1 Nme3 Adsl Nme2 Rrm2 Nme4 Rrm2b Ak1 Gmps Ak3 Ak2 Nme5 Ak5 Adss2 Adss1 Ak8 Atic Nme7 Ppat Nme6 Dscaml1 Guk1 Gart VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Rxra F13b Vdr Rara Gc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Grm2 Gng13 Cacna1e Grm4 Grm7 Grm8 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Rhoa Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Rap1a Gnb2 Rap1b Gnb4 Gnb3 Itpr3 Gngt1 Gng12 Itpr2 Adora2b Itpr1 Adora2a Grm1 Oprl1 Grm5 Sstr5 Sstr4 Rap1gap Oprd1 Sstr3 Drd1 Sstr2 Rasgrp3 Drd5 Sstr1 Rasgrp4 Gnao1 Gng2 Oprm1 Rasgrp1 Rasgrp2 Prkcq Arhgef1 Dnajc27 Drd2 Garnl3 Chrm1 Drd4 Prkcg Bdkrb2 Chrm3 Prkch Bdkrb1 Chrm5 Prkci Gpr45 Prkcb Adora1 Adora3 Gnrhr Prkcd Gnb1 Chrm2 Cacna1a Clta Prkce Chrm4 Cacna1b Cltb Prkca Cltc Prkcz Oprk1 Grm3 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Ephb2 Ephb3 Dll3 Rasa1 Dll4 Dlk1 Pdgfrb Apc Pdgfra Tek Pdgfa Pdgfb Grap Nck2 Jak1 Nck1 Ctnnb1 F2r Hspb1 Mapkapk3 Mapk14 Mapkapk2 Map2k4 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Jun Cryab Mapk8 Cryaa Kdr Akt1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Frs2 Pik3ca Crkl Frs3 Casp9 Nos3 Pik3c2b Pik3c2a Fgfr1 Ptk2 Pak1 Map2k2 Tgfb1i1 Map2k1 Pak3 Hras Pak2 Wnt5a Akt3 Akt2 Wnt5b Wnt10a Fos Wnt10b Gsk3b Notch4 Sos2 Notch1 Sos1 Notch2 Shc1 Rhoc Rhoa Rhob Rbpjl Wnt7b Stat3 Dvl1 Dvl2 Stat1 Dvl3 Wnt7a Map3k1 Wnt2 Wnt1 Tcf7l2 Fzd1 Fzd3 Fzd2 Fzd5 Crk Rbpj Src Wnt2b Grb14 Fgf1 Dok1 Dok2 Dok3 Axin1 Grb7 Pdgfc Tcf7 Pld1 Pdgfd Pld2 Efnb1 Jag2 Efnb2 Jag1 Pla2g4c Pla2g4d Birc5 Angpt1 Apc2 Epha3 Ephb1 Dll1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Nme1 Dut Dtymk Rrm1 Nme3 Dscaml1 Nme2 Rrm2 Nme4 Rrm2b Tyms Adat2 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Syt5 Syt3 Vamp1 Syt2 Syt1 Syt11 Syt12 Syt7 Syt6 Rab3a Snap25 Stxbp1 Unc13c Unc13b Stx1b Syt15 Stx2 Stx1a Unc13d GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Lyn Ppp3ca Jak2 Nfkbia Grb2 Mapk10 Eif4ebp1 Nr2c2 Clu Ier3 Sp1 Sp3 Elavl1 Akt1s1 Yes1 Snai1 Tcf4 Ryr2 Ryr1 Hbegf Ryr3 Ctnnb1 Nos1 Hdac7 Akap1 Cckbr Pparg Gucy2e Arhgef28 Cd38 Ptgs2 Camk4 Map2k5 Ptpn11 Tpcn1 Tpcn2 Bad Cck Gast Traf6 Map3k11 Srf Mef2d Elk1 Map2k6 Hspb1 Mapk14 Eif4e Map2k4 Mef2c Itpr1 Mapk1 Pla2g4a Prkd1 Prkacb Braf Prkd2 Mapk9 Mapk3 Jun Mapk8 Akt1 Bcl2 Rac1 Nfatc2 Plcg1 Araf Prkcq Prkch Prkcb Prkcd Prkce Prkca Raf1 Pik3r1 Prkg1 Creb1 Adcy1 Pxn Pik3cb Ptk2 Pak1 Map2k2 Map2k1 Odc1 Mapk7 Irs1 Rock1 Foxo1 Elk4 Cdh1 Pdpk1 Ywhab Foxo3 Fos Rps6ka3 Gsk3b Rps6ka1 Sos1 Shc1 Atf2 Itgav Rhoa Bcl2l1 Stat3 Itgb1 Mmp3 Plau Crk Src Gng2 Slc18a2 Bcar1 Casp3 Prkaca Bax Map3k14 Gnb1 Ptk2b Arrb2 Egr1 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Pgam2 Pfkm Gpi Hkdc1 Hk2 Hk1 Aldoa Tpi1 Pklr Bpgm Eno2 Pfkl Pkm EG433182 Pgk1 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Rbpj Ncor2 Dll3 Cirsr Dll4 Dlk1 Rbpjl Maml1 Numb Notch4 Notch1 Notch2 Notch3 Jag2 Jag1 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Gad1 Abat Aldh5a1 Gad2 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Casp9 Map2k4 Faf1 Parp4 Parp3 Apaf1 Parp2 Parp1 Cflar Fadd Lmnb1 Lmnb2 Gsn Casp6 Capg Lmna Mapk10 Scin Dffb Mapk9 Jun Mapk8 Fasl Casp8 Casp7 Casp3 Fas Daxx Map3k5 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Jund Vav1 Grap Jak2 Kras Myo3a Myo3b Junb Myh1 Myh2 Myh3 Plcb4 Myh8 Plcb3 Myh9 Myh4 Gna11 Gng10 Myh6 Myh7 Gna14 Plcd1 Plcb2 Vwf Plcd4 Plcb1 Gng3 Gng4 Myh11 Gng7 Myh14 Gnaq Myh13 Gng8 Plcz1 Plce1 Myh10 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 Mapk1 Prkx Prkacb Cxcr3 Cxcr5 Mapk3 Cxcr6 Cxcl10 Jun C5ar1 Fpr1 Rac2 Ccr10 Akt1 Ccr1 Nfatc4 Xcr1 Ccrl2 Rac1 Nfatc3 Gnao1 Ltb4r2 Nfatc2 Plcg1 Rhog Araf Fpr-s1 Ccr9 Plcg2 Ccr8 Ccr7 Ccr6 Gnai2 Nfatc1 Nras Ccr5 Prkcb Ccr4 Ccr3 Gnai3 Ccr2 Cx3cr1 Ifnar1 Prkce Camk2d Ccl11 Raf1 Ccl12 Ccl7 Camk2a Ccl5 Ccl4 Adcy5 Ccl3 Adcy6 Ccl2 Pf4 Prex1 Pik3cg Cx3cl1 Prkcz Nfat5 Col14a1 Pik3cb Ccl22 Pik3cd Ccl20 Mylk2 Pik3ca Mylk3 Pak1 Pak6 Pak3 Pak2 Ikbkb Pak5 Arpc1b Pak4 Arpc1a Cxcr1 Mylk Cxcr2 Arpc4 Rock1 Cask Pdpk1 Akt3 Ifng Akt2 Arpc3 Acta1 Acta2 Actb Arpc2 Sos1 Shc1 Arpc5 Il2 Cxcr4 Col12a1 Rhoc Rhoa Nfkb2 Stat3 Itgal Rela Chuk Relb Itgb7 Actg1 Itgb1 Rras Actbl2 Actc1 Col20a1 Arpc5l Gng2 Adcy2 Prkaca Col6a1 Col6a2 Ptk2b Gnai1 Col6a3 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Hprt1 Pnp Gda HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Hip1 Bdnf Ift57 Dync1h1 Grin1 Dnal4 Dctn1 Rhoj Rhoq Dync1i2 Dync1i1 Arpc1b Ap2a2 Ap2a1 Tubb5 Arpc1a Hap1 Tubb6 Hip1r Tubb3 Kalrn Tubb1 Htt Gapdhs Dync1li2 Dync2h1 Grik5 Dync1li1 Dnai2 Tubb4b Dynll1 Grik2 Dynll2 Grik1 Tubb4a Capn9 Grik4 Cyc1 Grik3 Capn5 Grin2d Sp1 Capn7 Grin2c Capn6 Capn1 Grin2b Capn3 Capn2 Dnah3 Dlg4 Dnah5 Dnah8 Cyfip2 Cyfip1 Capns1 Trp63 Fos Capn10 Capns2 Capn11 Acta1 Acta2 Actb Trp53 Actr2 Crebbp Arpc5 Trp73 Ep300 Map2k4 Apaf1 Map3k10 Tbp Actg1 Actbl2 Actc1 Map2k7 Mapk9 Jun Arpc5l Rac2 Taf4 Rac1 Casp8 Rhog Casp3 Cltb Tubb2b Tubb2a Grin2a ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Pdha2 Pklr Acly Pcx Cs Pkm Me1 Clybl Pdha1 Pck1 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Vav3 Vav1 Pak1 Map2k2 Vav2 Map2k1 Pak3 Hras Pak2 Ikbkb Nck2 Ptprc Ppp3ca Ppp3cb Nck1 Nfkbia Akt3 Akt2 Grap2 Fos Sos2 Zap70 Sos1 Cd28 Cd86 Cd80 Lck Lcp2 Cd3g Cd247 Cd3e Cd3d Ppp3cc Lat Chuk Map3k1 Itpr1 Mapk1 Braf Pik3c3 Mapk9 Mapk3 Jun Mapk8 Akt1 Rac1 Plcg1 Araf Prkcq Nras Raf1 Pik3r1 Pik3r2 Pik3cg Pik3cb Pik3cd Pik3ca TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Irak4 Ticam1 Ecsit Mapk14 Nfkbie Tollip Irak1 Map2k2 Myd88 Tank Map2k1 Irf3 Tlr9 Chuk Ikbkb Tlr8 Tlr7 Tlr6 Tirap Tlr4 Tab1 Tlr3 Tlr2 Nfkbia Mapk9 Mapk3 Jun Mapk8 Map2k3 Traf6 Elk1 Map3k7 Map3k8 Ikbke Tbk1 Ticam2 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Pdxk Psat1 Pnpo WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Csnk1d Csnk1e Smarca5 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Smad1 Smad4 Ctnnb1 Ppp2cb Ppp2ca Smad5 Siah1a Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 Nfatc4 Nfatc3 Nfatc2 Gng13 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Lrp6 Lrp5 Wnt6 Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Tcf7l2 Wnt3 Fzd1 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Axin1 Arrb2 Arrb1 Hdac1 Ppp3ca Ppp3cb Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb6 Pcdhgb7 Cdh5 Cdh4 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Crebbp Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Ep300 Pcdha5 Pcdha4 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Pcdh11x Cdh17 Cdh16 Prkcq Cdh15 Cdh13 Prkcg Cdh12 Prkch Cdh11 Prkci Nfatc1 Cdh10 Prkcb Pcdh8 Pcdh7 Pcdh9 Prkcd Pcdhgb1 Pcdhga5 Prkce Pcdhga6 Prkca Pcdhga7 Pcdhga8 Pcdhga1 Pcdhga2 Pcdhga3 Prkcz Gsk3b Ppp3cc Arr3 Smarce1 Srcap Tbl1x Nlk Kremen2 Kremen1 Siah2 Ino80 Csnk2a2 Ep400 Hells Hltf Csnk1a1 Ppp2r5d Smarcal1 Ppp2r5c Gng2 Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Arid1a Fbxw11 Btrc Pygo2 Pygo1 Tle4 Tle3 Tle2 Tle1 Gnb1 Ctnna3 Ctnna2 Ctnna1 Tle6 Bcl9 Csnk1g3 Hdac3 Csnk1g2 Hdac2 Tbl1xr1 Smarcb1 Hdac8 Csnk2b Smarca2 Sag Smarca1 Smarca4 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Hprt1 Xdh Aprt Ada Pnp TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Grm2 Gng3 Gng4 Gng7 Gng8 Gngt2 Vamp8 Vamp1 Gnb2 Gnb4 Vamp3 Gnb3 Vamp2 Gnb5 Snap29 Snap25 Prkar1a Prkar1b Prkx Snap23 Prkacb Gnao1 Prkar2a Prkar2b Prkaca Gnai2 Gng11 Gnai3 Gnb1 Cacna1e Cacna1a Adcy10 Cacna1b Gnat2 Gnai1 Stx1b Cacnb1 Stx1a Gng10 Grm3 UNTITLED%PANTHER PATHWAY%P05916 untitled Gnao1 Gng3 Gng2 Gng4 Adcy7 Gng7 Adcy2 Gng8 Avp Gngt2 Oxt Gnai2 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 Gnb1 Gng12 Gnai1 Pdyn Gng10 Oprk1 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Rhoa Rac1 Arhgef1 Pak1 Fyn Dpysl2 Nrp1 Dpysl4 Plxnb1 Sema3a Sema4d Dpysl5 Cdk5 Fes Dpys Crmp1 Frk Rac2 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Plcb1 Gnao1 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gng11 Gnb3 Gnai3 Gnb1 Cacna1a Cacna1b Gnai1 Grm1 Grm5 Cacna1g Plcb3 Cnr1 Plcb2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Cavin1 Ubtf Ttf1 Psmc3ip Tbp Tbpl2 Tbpl1 Taf8 Rrn3 Taf1c Taf1a Polr1b Taf1b Polr1d Polr2k PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway Pdxk Pnpo SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Cda Tk1 Adat2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Gng3 Gng2 Gng4 Adcy7 Prkar2a Gng7 Adcy2 Prkar2b Gng8 Gngt2 Prkaca Gnb2 Gnb4 Gnb3 Gnb5 Gnb1 Gnal Gng12 Prkx Prkacb Adrb2 Gng10 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Oprd1 Gnao1 Gng2 Adcy7 Oprm1 Adcy2 Prkar2a Prkar2b Prkaca Gnai2 Gnai3 Gnb1 Gnal Gnai1 Pdyn Creb1 Penk Gng10 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Plcb1 Adra2a Prkcg Plce1 Prkcd Prkce Prkca Itpr1 Adra2c Adra2b Plcb4 Plcb3 Gna11 Adra1b Adra1a Plcb2 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Agt Ace ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway Kdr THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Pdha1 Idh3g Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Ikbkb Cd40 Mapk14 Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 Cd40lg Dusp1 Nfkb1 Chuk Tnfaip3 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Vac14 Sacm1l Inpp1 Pik3cb Pik3r4 Plcb4 Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Impa1 Mtor Isyna1 Becn1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Agt Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Gys1 Gaa Agl Ugp2 Pygl Amy1 Pgm1 Ugdh Gpi Ugt3a2 Gusb Pgm2l1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 Cyp2c65 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Gls2 Glud1 L2hgdh Pcx D2hgdh Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Gusb Ugt8 Hk1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Mapk8 Nfkbia Shc1 Map3k1 Ptpn7 Cd3g Cd247 Nfkb1 Elk1 Map2k7 Cd3d Mapk3 Ubc Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Fos Rela Nfat5 Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Nqo1 Nos3 Abcb1a Abcg2 Ralbp1 Por Abcc1 Abcc2 Slc22a16 Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 Cbr1 Akr1c18 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Amt Cps1 Glul Dld Gls2 Glud1 Hal Sds Gldc Aqp8 Asrgl1 Asns TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Map2k1 Itpr1 Raf1 Cacna1f Cacna1c Cacna1d Hras Mapk1 Cacna1s Nfkbia Nfkb1 Prkcb Mapk3 Prkca Rela Plcb1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Itpr1 Prkca Gnaq Plcb1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Synj1 Vac14 Inpp4b Pik3c2a Pten Pik3c3 Pik3r4 Egfr Pik3r1 Fig4 Cdipt Ambra1 Pik3cd Pip5k1a Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Erbb2 Plcb1 Becn1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Srm Odc1 Mat2b Mat2a ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Agt Ace MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Ldhd Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Gmds Pfkl Tpi1 Fbp1 Aldoa Gmppa Pmm1 Mpi Uxs1 Akr1b1 Sord Khk Pfkfb1 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Tyms Rrm2b Dck Cmpk1 Nme1 Dctd Nt5c Slc28a3 Slc29a1 Slc28a1 Ctps1 Rrm1 Rrm2 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Pdia2 Sdf2l1 Comt Hyou1 Cyp2e1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a5 Ugt1a1 Hspa5 Ephx1 Cyp3a16 Cyp2c50 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Nqo1 Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Hsd17b10 Acat1 Hadh Acadl Acads Acaa2 Echs1 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Cyp3a16 Cyp2d22 Sult1a1 Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Qars1 Rps15a Rps18 Rps19 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Aldh1a1 Cyp3a16 Cyp2b10 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Agt Ace DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Dct Tyr PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Gmds Pfkl Tpi1 Fbp1 Aldoa Gmppa Pmm1 Mpi Uxs1 Akr1b1 Sord Khk Pfkfb1 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway Cyp3a16 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Agt Ace INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Creb1 Gngt1 Fshr Prkacb Cga Gng12 Ppp1ca Gnb1 Adcy2 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Ddc Pnmt Th GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Acsm1 Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2b10 Ugt1a9 Slc22a1 Abcc2 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Per1 Npr1 Cry1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Map2k1 Lyn Lck Cd79b Grb2 Orai1 Blnk Raf1 Hras Mapk8 Shc1 Map3k1 Elk1 Prkcb Mapk3 Plcg1 Rac1 Prkca Ppp3ca Jun Ppp3cb Syk Fos Nfat5 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Tub Gngt1 Chrm1 Htr2c Gnaq Gnb1 Plcb1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Eprs1 Rpl4 Rps16 Rps15a Rps18 Rps19 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Farsa Farsb Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Agt Ace GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Bpgm Pgam1 G6pc1 Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Cyp3a16 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Cyp2e1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a1 Hspa5 Abcb1a Sult1e1 Sult2a1 Abcg2 Abcc4 Abcc5 Abcc1 Ugt2b36 Gstt1 Cyp2d22 Sult1a1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Pccb Mmut Dbt Dld Bckdhb Sds Pcca Bckdha METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp3a16 Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Ugt1a9 Cbr1 Cyp2d22 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Aars1 Rps16 Rps15a Rps18 Rps19 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Sdhd Sdhc Sdhb Sdha Ndufa1 ATP6 mt-Co1 Uqcrc1 Atp5f1d Atp5f1c Atp5pb Atp5f1b Atp5f1a Gpd2 Slc25a4 Slc37a4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Vkorc1 Nqo1 Ggcx LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Cyp3a16 Cyp1a2 Scn1b 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs Acacb Spcs1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Agt Ace OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Gaa Ugp2 B4galt1 G6pc1 Pgm1 Gale Glb1 Lct Gla Akr1b1 Hk1 Galt FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp3a16 Aldh3a1 Cyp2e1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpk1 Inpp4b Nudt3 Minpp1 Itpka Inpp4a Ipmk Ippk Impa1 Bpnt1 Ip6k1 Isyna1 Inpp5j BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Acat1 Hadh Acads Echs1 Acsm1 Hmgcl Oxct1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Fdps Hmgcr Acat1 Idi1 Mvd Mvk Fdft1 Lss Sqle Pmvk BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Gpi Pkm Pfkp Tpi1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Pgs1 Gpam Gpd1 Crls1 Cdipt Cds1 Pla2g2d Ptdss1 Ptdss2 Gde1 Plpp1 Pisd Phospho1 Pld2 Pcyt1a Pla2g15 Lypla1 Ptpmt1 Chat Dgka Pemt Chka Agpat1 Gpd2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C9 Cfp C8a Cfb Cfd C3 C5 C6 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Slc6a4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Sptlc1 Acer2 Cerk Sptlc2 Enpp1 Degs2 Gba1 B4galt2 Ugt8 Sphk2 Ugcg Sdr16c5 Gla HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Cat Sod3 Sod2 Tyrp1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Cyp3a16 Abcb1a Abcg2 Pdia2 Sdf2l1 Abcc1 Abcc2 Hyou1 Pdia6 Pdia4 Ppib Bche Dnajb11 Ces2h Ces1d Ugt1a9 Top1 Erp29 Ugt1a1 Hspa5 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Agt Ace WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Ireb2 Gsr Glud1 Pkm Sdhd Sdhc Hk1 Sdhb Sdha Cs EG433182 Idh3g Mdh1 Pgd Mpc1 Fh Idh1 Idh3a Slc2a13 Cad Gapdhs Bpgm Aco1 Rpia Gpi H6pd Tktl1 Taldo1 Pfkm Bckdhb Pdhx Aldoc Gls Acly Ogdh Pgk2 Sucla2 Slc16a1 PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway Cyp3a16 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Tubb1 Cdkn1a Abcc10 Cyp3a16 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Map2k1 Socs1 Irs1 Grb2 Insr Ptpn6 Raf1 Ghr Stat5a Stat5b Hras Mapk1 Rps6ka1 Slc2a4 Ins2 Sos1 Jak2 Shc1 Mapk3 Plcg1 Prkca KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Slc14a2 Atp1a2 Atp1a1 Atp1a3 Aqp3 Aqp2 Atp6v1b1 Ca1 Slc4a1 Scnn1a Scnn1b Scnn1g Atp1b1 Atp1b3 Atp1b2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Vac14 Pik3c3 Pik3r4 Ptpmt1 Pik3cd Prex1 Inpp5f Plce1 Inppl1 Zfyve16 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Vars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Mapk8 Map3k1 Jun Faf1 Arhgdib Map3k7 Pak1 Prkdc Ripk2 Fasl Parp1 Cflar Pak2 Lmnb1 Ptpn13 Lmnb2 Casp8 Rb1 Casp7 Casp3 Casp6 Sptan1 Lmna Map2k4 Fas Fadd Daxx Dffa Dffb ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Tubb1 Slco1b2 Abcb1a Abcg2 Abcc1 Tuba1b Abcc2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Agxt Gpt Mpc1 Pcx Aars2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Rpe Rpia Tpi1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Adam17 Prkca Erbb4 Erbb3 Psen1 Nrg2 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Agt Ace FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Alox15 Ugt1a2 Cyp4f17 Cyp4f15 Slc22a8 Ptgds Cyp3a16 Cyp2j6 Cyp4f3 Cyp2c50 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Pdia2 Ptgis Sdf2l1 Cyp2c65 Hyou1 Cyp2e1 Pdia6 Ephx2 Pdia4 Ptgs1 Ppib Alox12b Slc22a6 Dnajb11 Ptgs2 Ugt1a9 Erp29 Cbr1 Ugt1a1 Hspa5 Ugt2b1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Aqp1 Slc7a8 Slc7a9 Slc4a4 Slc6a20a Slc9a1 Ca1 Slc22a2 Slc22a6 Slc1a1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 Slc7a5 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Map2k1 Grb2 Ptpn6 Raf1 Epo Epor Stat5a Hras Sos1 Jak2 Mapk8 Shc1 Elk1 Mapk3 Plcg1 Jun Fos CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp3a16 Oprm1 Cyp2d22 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Rpe Rpia Pgm1 Dera Prps1 Gpi Pgls Pfkl G6pdx Tkt Fbp1 Aldob HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Rapgef4 Glp1r Camkk1 Itpr3 Abcc8 Cacna2d2 Cacna1a Slc2a2 Chrm3 Cacnb1 Prkca Gng2 Adcy10 Gnaq Vamp2 Gnb1 Plcb1 Rab3a LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Creb1 Htr6 Gngt1 Prkacb Ppp1ca Gnb1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Cyp3a13 Cyp3a16 Oprm1 Cyp2d22 Grin2a Cyp2c50 Cyp2b10 Grin1 Cyp2c65 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Cbs Cth Mettl6 Mars1 Scly Sephs2 Ggt1 Mat2b Slc39a8 Papss1 Mat2a GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Gngt1 Prkacb Gnb1 Adcy2 Ptgdr DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gys1 Ganab Hkdc1 Pgm2 Gpi Gbe1 Hk1 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Itpr1 Akt1 Adcy1 Rock1 Lpar4 Srf Gng2 Gnb1 Plcb1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Ntpcr Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Hsd17b1 Cyp19a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 Asns CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Map2k1 Itpr1 Nfkb1 Prkcb Raf1 Mapk3 Hras Mapk1 Prkca Nfkbia Rela Plcb1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Acss1 Haao Mif Dbh Tyr Fah Comt Cyp2e1 Dct Cat Aldh1b1 Aldh2 Acss2 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Map2k1 Irs1 Grb2 Ptpn6 Raf1 Ghr Stat5a Stat5b Hras Mapk1 Rps6ka1 Slc2a4 Ins2 Jak2 Shc1 Mapk3 Gh Plcg1 Prkca 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Agxt Gpt Mpc1 Pcx Aars2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Ugp2 Pgm1 Ugdh Galk1 Gale Gck Uxs1 Galt PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Akt1 Plcg1 Pik3cg Prkca Pik3r6 Vav1 Plcb1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Nmnat3 Nmnat2 Nadk Nqo1 Npr1 Nmnat1 Clock Nampt Ppargc1a Rora Sirt1 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Htr7 Creb1 Gngt1 Prkacb Ppp1ca Gnb1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Ugt1a2 Slc22a8 Cyp3a16 Cyp2c50 Pdia2 Sdf2l1 Cyp2c65 Hyou1 Pdia6 Ptgs1 Pdia4 Ppib Slc22a6 Dnajb11 Ptgs2 Ugt1a9 Ugt2b1 Erp29 Ugt1a1 Hspa5 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Pgam2 Galm Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Slc2a1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp1a2 Cyp2c50 Slc6a2 Slc6a4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Slc9a1 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Prkar1b Kcnj4 Chrm2 Prkar2a Kcnk1 Prkar2b Kcnq1 Atp1b4 Slc8a1 Mcu Adrb1 Atp1b1 Prkacb Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cyp1a2 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Chrna4 Chrna3 Cyp2b10 Ugt1a9 Cyp2a5 Fmo3 Chrnb2 Ugt1a5 Aox1 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Shmt1 Bbox1 Aldh9a1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Slc29a2 Paics Slc28a2 Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Nme2 Ak2 Ak1 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Slc29a2 Paics Slc28a2 Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Mpst Ctns Cdo1 Cth Cars1 Gclc Got1 Gclm Ldha MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Egfr Rasa1 Srf Stat6 Jak1 Egf Sos1 Stat3 Stat2 Mapk8 Stat1 Shc1 Map3k1 Elk1 Mapk3 Jun Fos Map2k1 Grb2 Raf1 Hras Map2k4 Prkcb Plcg1 Prkca FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Gmds Pfkl Tpi1 Fbp1 Aldoa Gmppa Pmm1 Mpi Uxs1 Akr1b1 Sord Khk Pfkfb1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Pdxp Pnpo Aox1 Pdxk Alpl NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Ugp2 Galk2 Pgm1 Ugdh Gale Uxs1 Hk1 Galt EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Agt Ace PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Mars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Tyms Ces1d Tymp Cda Slc28a1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Flad1 Rfk Acp1 Enpp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Ugt1a2 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Pdia2 Slc6a4 Sdf2l1 Slc6a3 Hyou1 Adra1a Pdia6 Scn10a Pdia4 Pcsk2 Ppib Chrna4 Dnajb11 Oprm1 Htr1a Ugt1a9 Erp29 Ugt1a1 Hspa5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Ugt2b36 Ugt2b1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Hsd17b10 Acat1 Hadh Acadl Acads Acaa2 Echs1 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Plpp1 Gnpat Cept1 Agps Agpat1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Sult1a1 Chst11 Sult2b1 Suox Papss2 Bpnt1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Agt Ace CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Ptgs1 Cyp3a16 Ptgs2 Cyp2d22 Ugt1a9 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Nme2 Ak2 Ak1 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Atp1a2 Atp1b1 Atp1a1 Atp1b3 Atp1a3 Gck Atp1b2 Treh Slc2a2 Slc5a1 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Cyp3a13 Maoa Cyp2d22 Cyp2c50 Aox1 Slc6a4 Maob ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Slc25a22 Gpt Slc1a4 Glud1 Slc38a4 Slc2a4 Slc2a2 Gpt2 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Tyms Rrm2b Dck Cmpk1 Nme1 Dctd Nt5c Slc28a3 Slc29a1 Slc28a1 Ctps1 Rrm1 Rrm2 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Gls2 Glud1 Pkm Pcx Sdhd Sdhc Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Pdha1 Idh3g Suclg1 Mdh1 Pgd Pklr Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Ldha Dlst Pdhb Aldob Idh3b Aco2 Dlat Aco1 Dld Rpia Gpi Pfkl G6pdx Pgk1 Taldo1 Tkt Slc2a2 Slc1a5 Hk2 Slc16a1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Gls2 Glud1 Pkm Pcx Pfkp Sdhb Sdha Cs EG433182 Dhtkd1 Suclg1 Mdh1 Pgd Mpc1 Suclg2 Fh Idh1 Idh3a Pdhb Idh3b Aco2 Dlat Tktl2 Aco1 Pdha2 Dld Slc16a4 Slc1a2 Rpia Gpi G6pdx Pgk1 Taldo1 Hk2 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Sc5d Cyp51a1 Hsd17b7 Nsdhl Msmo1 Dhcr7 Lbr Dhcr24 Ebp ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Tyk2 Mapk1 Jak1 Stat3 Mtor IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway Bche Oprm1 Ces2h Ces1d INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Vac14 Synj1 Plcb4 Pik3c3 Ptpmt1 Cct3 Pik3ca Ipmk Bpnt2 Impa1 Isyna1 Becn1 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Map2k1 Raf1 Hras Pik3ca Vav3 Rala Ralbp1 Casp9 Pld1 Rhoa Bad Ralgds Bcl2l1 Smad3 Elk1 Smad4 Chuk Apaf1 Akt1 Foxo4 Mapk3 Rac1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Cyp11a1 Agtr1a Hsd3b6 Gng2 Cyp21a1 Gnaq Gnb1 Cyp11b2 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Ddc Pnmt Th ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Egfr Abcb1a Abcg2 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Mpst Ctns Cdo1 Cth Cars1 Gclc Got1 Gclm Ldha ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b Itgb3 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Itpr1 Akt1 Adcy1 Rock1 Lpar5 Srf Gng2 Gnb1 Plcb1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Aldh1a1 Cyp3a16 Aldh3a1 Cyp2b10 Cyp2a5 Cyp2c65 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Glp1r Slc10a2 Gpbar1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Map2k1 Irs1 Grb2 Insr Raf1 Hras Mapk1 Slc2a4 Ins2 Sos1 Mapk8 Shc1 Akt1 Pik3cg Pik3r6 Irs2 Map2k2 Pdpk1 Foxo1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Lars1 Rps19 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Synj1 Nudt3 Ipmk Bpnt2 Impa1 Isyna1 Ip6k1 Ppip5k1 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Vac14 Synj1 Plcd4 Pik3c3 Pik3r4 Impa1 Becn1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b Itgb3 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Prkacb Drd1 Adcy2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Cyp3a13 Cyp3a16 Cyp2c50 Cyp2b10 Ephx1 Cyp2c65 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Cdkn1a Pcna Ccne1 Ccnd1 Gadd45b Cdk4 Cdk2 Bcl2 Cdk1 E2f1 Bax Rb1 Apaf1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C9 C8a Cfb C1qb C1qa C1rb Serping1 Masp2 C2 C4a C1s2 C1qc Mbl2 Cfd C3 C5 C6 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma4 Ubc Psmc6 Psma3 Psmc5 Psma6 Psma5 Psmc2 Psmc1 Psma2 Psmc4 Psmc3 Psma1 Ubd Psmd13 Ube2e1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmd4 Psmb2 Stub1 Uba1 Psma7 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Itpr1 Mapk8 Map3k1 Elk1 Map2k7 Jun Map2k1 Grb2 Raf1 Hras Mapk1 Pld1 Gna11 Src Fshb Lhb Gnrh1 Prkcb Gnrhr Hbegf Camk2a Cga Adcy5 Prkca Cdc42 Egr1 Mmp14 Erbb4 Lrrc7 Mmp2 Actn4 Plcb1 Atf4 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Nat1 Cyp3a16 Cyp1a2 Xdh Cyp2a5 Cyp2c65 Cyp2e1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Cyp3a16 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Gmds Gmppb Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Hk1 Fbp1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk Pfkfb1 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Gpi Hk2 Pkm Pfkp EG433182 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Cd79a Nfatc4 Nfatc1 Nfatc3 Nfatc2 Sos1 Ppp3cc Btk Mapk8 Shc1 Map3k1 Elk1 Mapk3 Rac1 Ppp3ca Jun Vav1 Ppp3cb Syk Fos Map2k1 Lyn Cd79b Grb2 Orai1 Blnk Raf1 Hras Prkcb Plcg1 Prkca LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Itpr1 Akt1 Adcy1 Rock1 Srf Gng2 Lpar1 Gnb1 Plcb1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Acat1 Hmgcl Bdh1 Oxct1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 Asns LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Mpo Cyp3a16 Top2a PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pcyt2 Pisd Pcyt1a Cept1 Pemt Chka HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Itpk1 Vac14 Sacm1l Inpp1 Minpp1 Pik3r4 Cct3 Ambra1 Pik3ca Plcd1 Itpka Miox Ptpmt1 Pi4ka Impa1 Isyna1 Becn1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Casp3 Gzmb Hmgb2 Endog Dffa Cad Casp7 Top2a GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b Itgb3 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Prkar1b Prkar2a Prkar2b Gngt1 Prkacb Prkar1a Adcy10 Prkaca Gnb1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Kars1 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Tktl2 Rpe Rpia Pgm1 Dera Prps1 Gpi G6pdx Taldo1 Pfkp Fbp1 Rbks TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Gusb Ugt8 Hk1 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C9 C2 C4a C8a C1s2 C1qc C1qb C3 C1qa C1rb C5 C6 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Pgam2 Bpgm Galm Pgam1 G6pc1 Gpi Pkm Pfkm Tpi1 Slc2a2 Aldob EG433182 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Fbp1 Hk1 Sord Aldoa CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Gusb Ugt8 Hk1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Nmnat2 Nt5c2 Nadk Enpp1 Pnp Nudt12 Nnmt Qprt Nmrk1 Bst1 Nampt Nnt Aox1 Nadsyn1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Gpi Hk1 Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Cyp3a16 Abcb1a Pdia2 Sdf2l1 Hyou1 Top2a Mpo Pdia6 Ptgs1 Pdia4 Ppib Dnajb11 Ptgs2 Erp29 Ugt1a1 Hspa5 Abcc3 Top2b IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Slc22a1 Abcb1a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Aanat Tph1 Kmo Inmt Aadat Wars2 Ddc Wars1 Tdo2 Kynu Cyp1a1 Acmsd Haao Ido1 Cat Aldh2 Afmid LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Ikbkb Traf6 Pfkp Slc25a1 Sdhd Ikbkg Sdhc Myd88 Sdhb Ly96 Nfkbia Sdha Cd14 Cs Tirap Tlr4 Nfkb1 Chuk Acaca Mdh1 Acly Me1 Rela HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Avpr2 Gngt1 Fshr Prkacb Gng12 Gnb1 Adcy2 COAGULATION%SMPDB%SMP0000586 Coagulation Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Cat Aldh1b1 Aldh2 Acss1 Acss2 Cyp2e1 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Gars1 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Gaa Ugp2 B4galt1 G6pc1 Pgm1 Gale Glb1 Lct Gla Akr1b1 Hk1 Galt BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Sc5d Cyp51a1 Hsd17b7 Nsdhl Msmo1 Dhcr7 Lbr Dhcr24 Ebp TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Tubb1 Slco1b2 Abcb1a Abcg2 Abcc1 Tuba1b Abcc2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nmnat3 Nmnat2 Aifm2 Nadk Cd38 Nqo1 Nmnat1 Nampt Trp53 Sirt1 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Gls2 Glud1 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh2 Idh3a Ldha Dlst Me1 Slc7a7 Pdhb Idh3b Aco2 Dlat Dld Got2 Mycbp Slc38a5 Slc1a5 Slc1a4 Acly Slc16a1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Rpe Rpia Tpi1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Atp1a2 Clcnkb Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Slc12a6 Slc12a1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Eprs1 Rpl4 Rps16 Rps15a Rps18 Rps19 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Ddc Pnmt Th SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Map2k1 Raf1 Hras Mapk1 Nfkbia Nfkb1 Gngt1 Mapk3 Cxcl12 Plcg1 Pxn Ptk2b Pik3c2g Crk Ptk2 Bcar1 Cxcr4 Gnai1 Gnaq Gnb1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Agt Agtr1a Ace DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Maoa Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Maob Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Aox1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Fbp2 Aldoc Pfkm Tpi1 Hk1 Aldob LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Cyp3a16 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cyp1a2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Agxt Gpt Mpc1 Pcx Aars2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Tnf Map2k6 Map4k2 Map2k3 Tradd Cradd Ikbkb Mapk14 Ikbkg Mapk8 Nfkbia Map3k1 Nfkb1 Chuk Map2k7 Map2k4 Jun Casp2 Ripk1 Tank TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Akt1 Plcg1 Prkca Pik3r6 Plcb1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Hadha Hadhb Hadh Acadl Cpt2 Acaa2 Cpt1a Slc25a20 Acsl1 Echs1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Inpp1 Itpka Nudt4 Ip6k2 Inpp4a Ipmk Impa1 Isyna1 Ppip5k1 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Bpgm Pck1 Pgam1 G6pc1 Gpi Pank3 Pcx Tpi1 Slc2a2 Fbp1 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Aldob PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Grin2a Kcnd2 Cyp2b10 Cyp2a5 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Ugt1a9 Ugt1a5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Chrna3 Atp1b1 Fmo3 Cacnb1 Atp1b3 Atp1b2 Aox1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Maoa Aldh3a1 Aoc1 Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Carns1 Hars2 Aldh2 Ftcd Hal Cndp1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Iars1 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Slc25a11 Got2 Slc25a12 Mdh2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Aldh7a1 Gnmt Mat2a Chdh Dmgdh Shmt2 Sardh Slc44a1 Bhmt Slc44a2 Mtr Shmt1 Mat2b PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C9 Masp2 C2 C4a C8a Mbl2 C3 C5 C6 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca Fasn CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Tyms Ces1d Tymp Cda Slc28a1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rars1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Mpo Cyp3a16 Top2a TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Slc25a11 Pdha1 Mdh1 Mpc1 Pcx Acly Me1 Pdhb CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway P2ry12 Cyp3a16 Cyp1a2 Cyp2c50 Cyp2b10 Pon1 Abcb1a CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Adra1a Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Hadha Hsd17b10 Hadhb Acaa2 Mecr Echs1 Ppt1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Tnf Map2k6 Map2k3 Mapk14 Sos1 Btk Mapk8 Gab2 Map2k7 Fyn Rac1 Il13 Syk Pla2g4a Fcer1a Il4 Il5 Map2k1 Kras Lyn Pdk1 Grb2 Ms4a2 Nras Raf1 Fcer1g Pik3r1 Csf2 Lat Lcp2 Hras Mapk1 Pik3ca Vav3 Akt1 Map2k4 Plcg1 Prkca Map2k2 Inpp5d DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Gls2 Glud1 L2hgdh Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Tktl2 Rpia Gpi Prps2 G6pdx Taldo1 Pfkp Fbp1 Rbks Rpe Pgm1 Dera Pgls SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Creb1 Mapk3 Ikbkb Mapk1 Prkca Nos3 Ikbkg Plcb1 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs Acacb Spcs1 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 Asns ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Gad1 Cdo1 Csad Ado Ggt6 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Slc29a2 Paics Slc28a2 Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Ngf Fgf1 Ccnd1 Chaf1a Hoxb9 Btg2 Rb1 Btg1 Prmt1 Trp53 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1b1 Nos3 Trpv4 Prkg2 Prkg1 Gucy1a1 Trpc7 Kcnq5 Kcnq4 Trpc4 Kcnq3 Gucy1a2 Trpc3 Kcnq2 Adcy10 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp3a16 Cyp2d22 Cyp1a2 Cyp2c50 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Dck Cmpk1 Nme1 Slc22a1 Nt5c Pgk1 Abcb1a Abcg2 Abcc4 Abcc1 Abcc2 Slc22a2 Pcyt2 Pcyt1a Sult1a1 Slc22a3 Abcc3 Chpt1 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Abcb1a Slc6a2 Slc6a4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Ugp2 Pgm1 Ugdh Galk1 Gale Gck Uxs1 Galt ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c65 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Cyp3a16 Abcb1a Pdia2 Sdf2l1 Hyou1 Top2a Mpo Pdia6 Ptgs1 Pdia4 Ppib Dnajb11 Ptgs2 Erp29 Ugt1a1 Hspa5 Abcc3 Top2b OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Gusb Ugt8 Hk1 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification Gsto1 Aqp9 Aqp7 Pnp Slc2a4 As3mt Slc2a1 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Itpk1 Inpp4b Nudt3 Inpp1 Minpp1 Itpka Impa1 Isyna1 Ip6k1 Ppip5k1 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Sars1 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Itpr1 Akt1 Lpar2 Adcy1 Rock1 Srf Gng2 Gnb1 Plcb1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Klb Fgf15 Nr1h4 Fgfr3 Slc10a2 Fgfr4 Fgfr1 Fgfr2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Galm Slc2a13 Pgk2 Aldob Gapdhs PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Sntb1 Abcc8 Cacnb1 Cacna2d2 Cacna1a Scn5a Gcg Slc2a2 Snta1 Sntb2 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Gmds Gmppb Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Hk1 Fbp1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk Pfkfb1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Gngt1 Prkacb Ptgir Myl3 Gnb1 Adcy2 Mylk CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Ikbkb Mapk14 Traf6 Ikbkg Mapk8 Nfkbia Map3k1 Ecsit Tollip Nfkb1 Irak1 Tlr1 Chuk Tlr9 Tab3 Tlr8 Tlr7 Tab2 Tlr6 Tab1 Tlr5 Tlr3 Tlr2 Rela Map3k7 Myd88 Ly96 Cd14 Tirap Tlr4 Map2k4 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Cyp3a16 Abcb1a Abcg2 Pdia2 Sdf2l1 Abcc1 Abcc2 Hyou1 Pdia6 Pdia4 Ppib Bche Dnajb11 Ces2h Ces1d Ugt1a9 Top1 Erp29 Ugt1a1 Hspa5 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Coasy Enpp1 Vnn1 Pank1 Ppcs Ppcdc METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Agt Ace 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Map2k6 Ikbkb Rps6ka1 Mapk8 Nfkbia Map3k1 Bad Nfkb1 Elk1 Chuk Map2k7 Jun Atf2 Arhgef7 Adora2a Pak1 Braf Map3k4 Nfkb2 Prkcz Hras Mapk1 Rap1a Pard6a Pik3ca Rapgef3 Rapgef2 Mapk11 Akt1 Creb1 Gngt1 Prkacb Map2k2 Pdpk1 Gnb1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Itpr1 Prkca Gnaq Plcb1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Hadha Hsd17b10 Hadhb Acaa2 Mecr Echs1 Ppt1 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Tars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Glud1 Pkm Sdhd Sdhc Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Suclg1 Mdh1 Pklr Mpc1 Fh Idh1 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Rpia Gpi Pfkl G6pdx Pgk1 Taldo1 Tkt Slc1a3 Hk2 Gls Slc16a1 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Ugp2 Pgm1 Ugdh Galk1 Gale Gck Uxs1 Galt PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps15 Rps17 Rpl15 Rpl8 Rps20 Rps24 Rps14 Rpl4 Aars1 Rps16 Rps15a Rps18 Rps19 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Tubb1 Cdkn1a Abcc10 Cyp3a16 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Adra1a Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Agt Ace BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Nudt11 Prex1 Ipmk Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Maoa Aldh3a1 Aoc1 Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Carns1 Hars2 Aldh2 Ftcd Hal Cndp1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Cyp3a16 Cyp2c50 Pde4d MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Hadha Hadhb Hadh Acadm Acaa2 Slc25a20 Echs1 Acsm1 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Sult1a1 Chst11 Sult2b1 Suox Papss2 Bpnt1 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Hsd11b1 Akr1d1 Srd5a1 Hsd17b3 Pdia2 Sdf2l1 Akr1c6 Cyp19a1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Cyp11b1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 Cyp2c65 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Pdha1 Idh3g Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Kdr Flt1 Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Ugt1a2 Pdia2 Sdf2l1 Ugt2b36 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Oprm1 Ugt1a9 Ugt2b1 Erp29 Ugt1a1 Hspa5 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Cyp3a16 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cyp1a2 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pcyt2 Pisd Cept1 Chka Ptdss1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Yars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Galm Slc2a13 Pgk2 Aldob Gapdhs LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Itpk1 Vac14 Inpp1 Minpp1 Pik3c3 Pik3r4 Fig4 Ambra1 Pik3ca Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Ippk Impa1 Plcd3 Isyna1 Becn1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2u1 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Hadha Ugt1a2 Hsd17b10 Hadhb Ivd Cyp2b10 Cyp2a5 Acadsb Acsm1 Ehhadh PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Dars1 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Atp1a2 Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Lct Slc2a2 Slc5a1 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Agt Ace METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Sntb1 Scn5a Snta1 Sntb2 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Aldh1a1 Abcc10 Cyp3a16 Cyp2d22 Cyp2b10 Ugt1a9 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Adam17 Egfr Prkca Erbb4 Erbb3 Psen1 Nrg2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Ccnd3 Wasf1 Cdkn1a Pcna Cfl1 Ppp1r12b Pak1 Ccnd1 Actb Cdk5 Myl2 Limk1 Pdgfra Arfip2 Vav3 Ralbp1 Pld1 Mylk Map3k1 Rac1 Cap1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Bpgm Pgam1 G6pc1 Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Gusb Ugt8 Hk1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Tnf Tradd Ikbkb Traf6 Tnfrsf1b Tnfrsf1a Ikbkg Ncoa3 Camkk2 Nfkbia Il1a Map3k1 Il1r1 Map3k14 Nfkb1 Irak1 Chuk Ubc Tab1 Rela Map3k7 Camkk1 Myd88 Tlr4 Fadd Ripk1 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Cyp2b10 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Cyp2c65 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Glud1 Pkm Pcx Sdhc Sdhb Cs EG433182 Pgam2 Pdha1 Idh3g Suclg1 Mdh1 Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Dlst Pdhb Aldob Idh3b Aco2 Aco1 Dld Rpia Gpi Pfkl G6pdx Pgk1 Tkt Slc2a2 Slc1a5 Pdhx Ogdh Slc16a1 CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl4 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Hsd17b1 Cyp19a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Aldh7a1 Bhmt Ahcy Mtr Pemt Mat2b Mat2a Chdh BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs Acacb Spcs1 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Agt Ace ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Cars1 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Agxt Gpt Mpc1 Pcx Aars2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Cyp3a16 Impdh1 Ces2h Ces1d Ugt1a9 Slco1b2 Abcb1a Abcg2 Cyp2c65 Abcc2 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Aldh1a1 Cyp3a16 Cyp2b10 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway P2ry12 Cyp3a16 Cyp1a2 Cyp2c50 Cyp2b10 Pon1 Abcb1a TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Duox1 Tpo Tg Cyba Cybb Nox4 Nox3 Duox2 Slc5a5 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Amigo3 Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Fbp1 Mpi Akr1b1 Sord Pmm2 Aldob Khk Tgds Pfkfb1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Map2k6 Ikbkb Rps6ka1 Mapk8 Nfkbia Map3k1 Bad Nfkb1 Elk1 Chuk Map2k7 Jun Atf2 Adora2b Arhgef7 Pak1 Braf Map3k4 Nfkb2 Prkcz Hras Mapk1 Rap1a Pard6a Pik3ca Rapgef3 Rapgef2 Mapk11 Adcy2 Akt1 Creb1 Gngt1 Prkacb Map2k2 Pdpk1 Gnb1 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Bpgm Pgam1 G6pc1 Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Sst Abcc8 Cacnb1 Cacna2d2 Cacna1a Slc2a2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Irs1 Tsc2 Insr Eif4ebp1 Tsc1 Eif4e Ins2 Akt1 Pik3cg Pik3r6 Irs2 Mtor Slc7a5 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Acat1 Hmgcl Bdh1 Oxct1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling P4ha3 Tlr4 Hif1a Il1b Sirt3 Nlrp3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Cyp3a16 Ugt1a9 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Oprk1 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Creb1 Gngt1 Prkacb Ppp1ca Htr4 Gnb1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Cyp1a1 Sult1e1 Pdia2 Sdf2l1 Hsd17b1 Comt Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Itpr1 Map2k3 Egfr Mapk14 Cacna2d2 Sos1 Mapk8 Map3k1 Elk1 Map2k7 Jun Map2k1 Grb2 Raf1 Cacna1f Cacna1c Cacna1d Hras Mapk1 Cacna1s Map3k2 Pld1 Gna11 Src Fshb Lhb Gnrh1 Adcy1 Prkcb Gnrhr Hbegf Camk2a Cga Cacnb1 Prkca Egr1 Mmp14 Mmp2 Prkaca Actn4 Plcb1 Atf4 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Vac14 Sacm1l Minpp1 Pik3c3 Pik3r4 Cct3 Ambra1 Plcd1 Itpka Miox Ptpmt1 Inpp4a Ipmk Ippk Impa1 Bpnt1 Isyna1 Inpp5j Becn1 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Map2k6 Map2k3 Ikbkb Mapk14 Traf6 Ikbkg Mapk8 Nfkbia Map3k1 Ecsit Tollip Nfkb1 Irak1 Elk1 Chuk Tlr9 Tlr7 Tab2 Tab1 Jun Tlr3 Tlr2 Fos Rela Map3k7 Myd88 Eif2ak2 Ly96 Ppara Cd14 Tirap Tlr4 Map2k4 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Nfatc4 Nfatc1 Nfatc3 Nfatc2 Sos1 Ppp3cc Mapk8 Nfkbia Shc1 Map3k1 Ptpn7 Cd3g Cd247 Nfkb1 Elk1 Cd3d Mapk3 Ubc Fyn Pik3cg Rac1 Ppp3ca Jun Vav1 Ppp3cb Fos Rela Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Pik3ca Zap70 Cd3e Map2k4 Prkcb Plcg1 Prkca MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Slc29a2 Slc28a2 Impdh1 Slc28a3 Slc29a1 Abcc4 Abcc5 Xdh Gmps Rac1 Hprt1 Aox1 Adk Ppat Tpmt FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacnb1 Cacna2d2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Itpr1 Dlg4 Nos1 Xdh Grin2a Aldh2 Prkacb Prkca Ppp3ca Grin1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Glud1 Pkm Pcx Pfkp Sdhd Sdhc Hk1 Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Pdha1 Suclg1 Mdh1 Pgd Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Dlst Pdhb Dlat Tktl2 Aco1 Dld Slc16a4 Rpia Gpi G6pdx Pgk1 Taldo1 Gls Slc2a1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Pdxp Pnpo Aox1 Pdxk Alpl PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Synj1 Vac14 Inpp4b Pik3c2a Pten Pik3c3 Pik3r4 Egfr Pik3r1 Fig4 Cdipt Ambra1 Pik3cd Pip5k1a Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Erbb2 Plcb1 Becn1 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Mpst Ctns Cdo1 Cth Cars1 Gclc Got1 Gclm Ldha BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Slco1a4 Nr1h4 Slc10a2 Gpbar1 Abcc4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Pex14 Crat Phyh Cpt2 Pex13 Abcd2 Aldh2 Hacl1 Slc25a20 Acsl1 Abcd1 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Cyp3a16 Cyp2b10 Pdia2 Sdf2l1 Cyp2c65 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Mc2r Gngt1 Prkacb Pomc Gnb1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Gusb Ugt8 Hk1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Aldh1a1 Cyp3a16 Aldh3a1 Cyp2b10 Cyp2a5 Cyp2c65 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Dlg4 Nos1 Grin2a Prkacb Prkca Ppp3ca Grin1 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Arnt Ahr Hsp90aa1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Map2k1 Grb2 Raf1 Stat5a Rasa1 Srf Hras Egf Stat3 Jak2 Mapk8 Shc1 Map3k1 Elk1 Map2k7 Prkcb Mapk3 Plcg1 Prkca Jun Erbb4 Fos LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Akt1 Adcy1 Rock1 Lpar6 Srf Gng2 Gnb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Gmds Gmppb Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Hk1 Fbp1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk Pfkfb1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Gusb Ugt8 Hk1 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp1a2 Cyp2c50 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a13 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Fbp2 Aldoc Pfkm Tpi1 Hk1 Aldob PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Hars1 Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Cyp2d22 Slc6a2 Slc6a4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Lhb Creb1 Gngt1 Prkacb Lhcgr Cga Ppp1ca Gnb1 Adcy2 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Atp1a2 Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Lct Slc2a2 Slc5a1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Gpi Pkm Pfkp Tpi1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Dgat1 Gpam Gpd1 Lpin1 Agpat1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Dhtkd1 Dld Aldh8a1 Acmsd Dlst BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Wars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Itpk1 Inpp4b Nudt3 Inpp1 Minpp1 Itpka Inpp4a Ipmk Ippk Impa1 Ip6k1 Isyna1 Ppip5k1 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Hsd17b1 Cyp19a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Slc12a3 Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp4a Aqp3 Atp4b Aqp2 Slc8a1 Atp1b1 Atp1b3 Trpv5 Atp1b2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Tnf Mapk8 Gab2 Map2k7 Fyn Rac1 Il13 Syk Fcer1a Il4 Map2k1 Kras Lyn Lck Grb2 Ms4a2 Nras Blnk Raf1 Pik3r1 Csf2 Lat Hras Mapk1 Akt1 Plcg1 Prkca Map2k2 Inpp5d SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Ikbkb Mapk1 Nos3 Ikbkg Mapk11 Nfkb1 Ptgs1 Chuk Creb1 Mapk3 Prkca Sucnr1 Plcb1 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Cyp3a16 Cyp2d22 Sult1a1 Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Casp3 Arhgdib Apaf1 Gzmb Parp1 Jun Arhgap5 Casp8 Casp9 Casp1 Prf1 Arhgap32 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Fbp2 Aldoc Pfkm Tpi1 Hk1 Aldob ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Nars1 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Galm Slc2a13 Pgk2 Aldob Gapdhs INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Hrh2 Creb1 Gngt1 Prkacb Ppp1ca Gnb1 Adcy2 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Lpar3 Itpr1 Akt1 Adcy1 Gng2 Gnb1 Plcb1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Dlat Aco1 Dld Gls2 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260211%WP175%MUS MUSCULUS Acetylcholine synthesis Pcyt1a Pdha1 Pdha2 Chat Pemt Chka Ache STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP55%MUS MUSCULUS Steroid biosynthesis Hsd17b7 Hsd17b3 Hsd17b4 Cyp17a1 Hsd3b6 Hsd3b5 Hsd3b4 Hsd3b3 Hsd3b2 Hsd3b1 Hsd17b1 Hsd17b2 F13b FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5128%MUS MUSCULUS Fibrin complement receptor 3 signaling pathway Ifnb1 Ticam2 Akt1 Irak4 Ccl2 Nfkb1 Ticam1 Lbp Cxcl3 Fgb Fga Pik3ca Syk Nos2 Irak2 Irak1 Fgg Plat Cblb Myd88 Rela Ly96 Irf3 Fcer1g Itgb2 Rel Cd14 Chuk Tlr4 Tirap Tlr3 Ikbkb Cxcl10 Rassf5 Src Tyrobp Traf6 Il12b Ikbkg Plg Tnf Rhoa Il6 Itgam AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260211%WP1262%MUS MUSCULUS Aflatoxin B1 metabolism Akr7a2 Ephx1 Cyp1a2 Gstt1 Gstm1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260211%WP2910%MUS MUSCULUS Mecp2 and associated Rett syndrome Gad1 Apoc2 Gabrr2 Tet1 Tap1 Nrep Myt1 Arhgef26 Mag Mef2c Bcl6 Sst E2f1 Hnrnph1 Hnrnpf Oprk1 Ezh2 Taf1 Cdon Gamt Ncor1 Mecp2 Cnp Gprin1 Sin3a Csrp1 Bdnf Dlx5 Prpf3 Ybx1 Cebpd Fgf2 Smc3 Fgf4 Fgf3 Rbfox1 Rest Fut8 Ctcf Sp1 Sp3 Nf1 Mbp Pou3f2 Grin1 Pou4f1 Creb1 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260211%WP543%MUS MUSCULUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Hmgcs2 Acat1 GPCRS OTHER%WIKIPATHWAYS_20260211%WP41%MUS MUSCULUS GPCRs other Oprk1 Or8g20 Ghsr Gpr165 Or1e1f Gpr162 Prokr1 Adgrg1 Ednra Or8c9 Vmn2r104 Rrh Or1a1b Or1ad8 Or3a1 Or1e35 Or1e34 Vmn1r148 Oprl1 Adrb2 Adrb1 Vmn1r29 Vmn1r25 Or8g19 Or4b1d Or7e178 Or8d1 Sstr5 Smo Or8u8 Or1e23 Or5g26 Vmn2r107 Oprm1 Tacr3 Or4c58 Or51a5 Calcr Casr Vmn1r15 Or1p1 Vmn1r13 Or1x2 Vmn1r14 Vmn1r11 Or2a7 Or6a2 Tas1r1 Vmn1r10 Or2z2 Ccr10 Or9s13 Or10p22 Vipr1 Gpr88 Gpr84 Gpr83 Drd1 Celsr3 Drd2 Or6z7 Celsr1 Or7a37 Drd5 Celsr2 Fzd1 Xcr1 Fzd2 Fzd5 Fzd7 Or6b9 Fzd9 Or13p10 Or2b6 Or1a1 Or7e165 Adora1 Adora3 Ltb4r2 Or2n1e Or2t1 Tmigd3 Grm1 Gabbr1 Or51a10 Or1j1 Ccr7 Or13a18 Or13a17 Gpr132 Or7a42 Or7a41 Or7a40 Or2ag2b Mtnr1b Vmn2r32 Vmn1r65 Vmn1r62 Vmn1r63 Gpr39 Htr1d Or2y1b Gpr34 Htr1a V1ra8 Or13a28 Or13a27 Gpr143 Adgre5 Vmn1r58 Or2v1 Vmn1r56 Vmn1r53 Vmn1r54 Vmn1r51 Vmn1r52 Gpr146 Vmn1r50 Or3a1c Mc4r Or1e17 Or1d2 Or1e16 S1pr1 Pth2r S1pr2 S1pr5 Trhr2 Or51a39 Adgrf4 Vmn1r48 Vmn1r49 Vmn1r46 Or2w1 Vmn1r47 Gpr37l1 Irx6 Vmn1r44 Cysltr1 Vmn1r45 Vmn1r42 Vmn1r43 Ackr1 Vmn1r40 Cnr1 Vmn1r41 Or1f19 Or1j21 Mrgprh Or2a57 Vmn1r171 Vmn1r172 Or1m1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260211%WP4820%MUS MUSCULUS GDNF RET signaling axis Gdnf Sox11 Fat4 Gata3 Gfra1 Sall1 Robo2 Ret Grem1 Eya1 Sox17 Ift27 Agtr2 Slit2 Ctnnb1 Spry1 Pax2 Ift25 Gli3 Foxc2 Bmp4 Lhx1 Foxc1 GPCRS ORPHAN%WIKIPATHWAYS_20260211%WP1398%MUS MUSCULUS GPCRs orphan Gpr137b Adgrf5 Gpr137c Slc52a2 Gpr161 Adgrf2 Gpr180 Gpr107 Gpr137 Gpr4 Gpr179 Gpr155 Tpra1 Gpr108 Gpr89 Gpr31 Wls Gpr165 PURINE METABOLISM%WIKIPATHWAYS_20260211%WP2185%MUS MUSCULUS Purine metabolism Gda Pde7b Pde7a Entpd1 Nt5c Entpd2 Nt5c1a Pnp Nt5e Nt5c1b Entpd5 Pde6g Entpd6 Pde6h Entpd3 Entpd8 Nt5m Allc Polr1b Polr1c Ak1 Polr1a Ak2 Ak5 Polr1d Ak4 Polr1e Hprt1 Pde8a Ak7 Pde8b Ak6 Polr1h Ak8 Cant1 Ampd3 Ampd2 Ampd1 Adcy10 Npr1 Pola2 Pnp2 Pola1 Npr2 Adprm Pde9a Gucy1b1 Gucy1b2 Nt5c3a Pnpt1 Itpa Dguok Adss2 Adss1 Gucy1a2 Pde1b Ppat Pde1c Pde1a Paics Ada Pde10a Rrm2b Urad Adk Pde3a Urah Nudt16l2 Guk1 Pde2a Adcy3 Adcy4 Pgm2 Adcy1 Adcy2 Adcy7 Gart Adcy8 Pgm1 Adcy5 Adcy6 Pold2 Pold1 Adcy9 Nudt16 Pold4 Pold3 Pde4a Nme3 Gmps Pde4b Prps1l3 Nme2 Gmpr Nme5 Prps1l1 Nme4 Fhit Dck Nme1 Prim2 Prps1 Gucy2e Gucy2d Prps2 Gmpr2 Gucy2c Atic Pkm Nme7 Nme6 Pde3b Prim1 Gucy2f Pole3 Pole2 Adsl Impdh2 Pklr Polr2c Polr2d Polr2a Impdh1 Polr2b Taf9 Pole4 Polr2g Enpp1 Polr2h Enpp3 Polr2e Polr2f Pde5a Polr2l Polr2i Aprt Polr2j Polr3gl Pde4c Pde4d Nudt2 Hddc3 Xdh Nudt5 Polr3a Rrm1 Nudt9 Pde11a Rrm2 Polr3d Polr3e Polr3b Prune1 Polr3c Pde6c Polr3h Pde6d Pde6a Polr3f Pde6b Polr3g Pfas Polr3k Papss2 Papss1 Nt5c2 Pole Uox MRNA PROCESSING%WIKIPATHWAYS_20260211%WP310%MUS MUSCULUS mRNA processing Polr2a Polr2g Afg3l2 Afg3l1 Phf5a Igf2bp3 Rbm15b Igf2bp1 Eif2ak2 Rpl37 Rpl38 Rpl8 Rpl39 Rpl9 Rpl7 Znf830 Rpl32 Abcb4 U2surp Lsm11 Vmn1r26 Trmt2a Clp1 Rpl26 Snrpb2 Trmt1l Mbnl1 Rpl22 Snu13 Fdx2 Raly Cfb Dcaf1 Rad21 Snrpa1 Bard1 Mettl3 Ptbp1 Cpeb1 Cpeb3 Cpeb4 Rpl39l Eif4a3 Rnpc3 Eif4a2 Mcts2 Wdr55 Scaf8 Pabpc1 Pabpc2 Nelfe Tmed10 Zfp638 Csad Srp68 Pabpc4 Pabpc5 Pabpc6 Stau1 Rbm12b1 Rbm12b2 Slbp Zfp740 Srp9 Dazl Tert Rbm8a Tut1 Nip7 Gatc Rpl19 Sf3a1 Sf3a2 Sf3a3 Rpl11 Rpl12 Dazap1 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Dnajc17 Sf3b5 Sf3b6 Akap17b Srp54 Adat1 Atxn1 Fmr1 Rnpepl1 Msi1 Msi2 Alyref2 Rbm31y Hnrnpa2b1 Supt5h Rps9 Rps7 Rnmt Snrnp70 Rps6 Ilf3 Ncl Hnrnpdl Spop Zcrb1 Virma Htatsf1 Tmem163 Oasl2 Snrnp40 Prpf18 Eftud2 Snrpf Snrpe Snrpg Snrpb Snrpa Snrpc Snrpn Alyref Ppp1r14b Ggcx G3bp1 Smn1 Elmod3 Mrpl23 Tia1 Col4a3 Fus Cnot4 Lsm2 Lsm4 Secisbp2 Qki Lsm1 Cdk9 Son Lsm7 Lsm8 Rbpms Safb2 Eral1 Synj2 Aco1 Sbno1 Hnrnpab Ilkap Mrpl11 Rnpep Clasrp Srsf1 Ptbp3 Ptbp2 Ddx19b Srsf9 Srsf7 Ddx19a Srsf6 Srsf5 Adam5 Srsf4 Dis3 Srsf3 Srsf2 Ankar Eif4h Tsn Eif4e Snrnp35 Hnrnpa3 Pcolce Sart3 Puf60 Wbp4 U2af1 Ppil4 Eif3g Eif3b Mrm3 Hnrnpa1 Hnrnpa0 Zfp385a U2af2 Bicc1 Cstf2t Ciz1 Ssb Celf6 Celf5 Celf4 Celf3 Celf2 Eif2d Celf1 Pabpn1 Pskh1 Ro60 Sfswap Mak16 Park7 Ppm1g Dicer1 Slc25a4 Rngtt Smc1a Enox1 Enox2 Rps14 Rnps1 Ltv1 Rps11 Rps13 Myef2 Rbfox2 Prpf40a Prpf40b Cirbp Uhmk1 Cdc40 Ddx39a Hnrnpll Esrp2 Pcbp2 Imp3 Pcbp1 Ddx39b Pcbp4 Esrp1 Pcbp3 Imp4 Xrn2 Alkbh8 Hnrnpr Dhx8 Dhx9 Hnrnpu Rbms1 Rbm11 Rbms3 Rbm10 Rbms2 Rbm12 Fxr1 Oas1g Fxr2 Oas1b Oas1a Dhx38 Dnd1 Elavl4 Elavl2 Adarb2 Elavl3 Elavl1 Tial1 Rps27 Rps28 Aimp1 Rps29 Rps20 Pum2 Pum3 Sugp1 Rps23 Sugp2 Pum1 Rps24 Srpk1 Zrsr2 Hnrnpc Hnrnpd Hnrnpk Hnrnpl Srpk2 Hnrnpm Adad1 Cstf1 Nudt21 Prmt1 Auh Sltm Prmt2 Dhx16 Cstf2 Cstf3 Dhx15 Rsrc2 Rnasel Akap1 Slc6a8 Csde1 Rbpms2 Srsf11 Srsf12 Srsf10 Srrm1 Boll Prpf4b Slu7 Tlr5 Raver1 Nol8 Rae1 Npm1 Bclaf1 Ppargc1a Ppargc1b Ergic2 Tardbp Znf346 Brca1 Rnaset2b Hnrnph2 Prpf4 Prpf6 Rbmxl2 Rbmxl1 Pspc1 Zmat4 Zmat2 Rdm1 Fbl Ppie Tarbp2 Syncrip Zbp1 Rbmx2 Matr3 Mrps28 Rbm4b Prpf8 D1Pas1 Brwd1 Papolg Ppp1r8 Nono Papolb Papola Grsf1 Nop9 Clk1 Clk2 Clk3 Clk4 Ralyl Cpsf4 Cpsf7 Srp14 Cpsf1 Cpsf2 Cpsf3 Ddx1 Tdrd7 Ddx4 Ddx5 Srp19 Ddx6 Eif4e2 Slirp Rbm33 Dnajc8 Dis3l2 Rbm34 Taf15 Rbm26 Rbm3 Ddx3x Rbm4 Nufip1 Rbm25 Rbm28 Sfpq Lingo1 Ddx56 Rbm7 Rbm5 Rbm6 Ewsr1 Txnl4a Adar Naa38 Rbm22 Rbm14 Rbm17 Rbm19 Oas2 Rbm18 Ankrd33b Oas3 Ddx41 Spen Nifk Eif4g2 Poldip3 Eif4g3 Rpp14 Trim21 Nxf1 Rbm47 Ncbp2 Cyp4f3 Rbmy Cd2bp2 Rbmx Nxf7 Rps4x Snrpd2 Tnrc6c Snrpd1 Tra2b Acin1 Rbm42 Rbm41 Rbm43 Snrpd3 Rbm45 Rbm39 Rbm38 Ttc14 Znf622 Eif4e3 Ddx25 Naa12 Rnaseh2a Ddx24 Ddx21 Ddx20 Ttc39a Traf6 Prpf3 Ybx1 Rbfox1 Hnrnph1 Hnrnpf EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260211%WP318%MUS MUSCULUS Eicosanoid synthesis Pla2g6 Ptgs2 Ltc4s Tbxas1 Alox8 Alox5ap Pla2g2a Alox12 Alox5 Dpep1 Lta4h Alox15 Ptges Ptgds Ptgis Ptges2 Pnpla8 Ptgs1 Ggt1 ROBO4 AND VEGF SIGNALING PATHWAYS CROSSTALK%WIKIPATHWAYS_20260211%WP3864%MUS MUSCULUS Robo4 and VEGF signaling pathways crosstalk Vegfa Kdr Rac1 Src Slit2 Robo4 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260211%WP509%MUS MUSCULUS Nuclear Receptors Nr2c2 Nr3c1 Nr2e1 Hnf4a Nr1i3 Nr1i2 Ar Esrra Esrrb Rara Rarb Nr2f6 Rarg Thrb Nr1d2 Thra Nr0b1 Vdr Nr2f2 Nr2f1 Nr1h3 Rorc Ppard Nr1h2 Rora Ppara Esr1 Pparg Esr2 Rxrb Rxra Ror1 Pgr Rxrg Nr5a2 Nr5a1 Nr4a2 Nr4a1 CELL CYCLE%WIKIPATHWAYS_20260211%WP190%MUS MUSCULUS Cell cycle E2f6 Atr Smc1b Ccna1 Ccna2 Mcm7 Ccne1 Ccne2 Dbf4 Ywhag Hdac3 Hdac2 Hdac5 Hdac4 Cdh1 Hdac1 Cdkn2a Hdac7 Tfdp1 Skp2 Hdac6 Pkmyt1 Cdc20 Ccnb2 Ccnb3 Mad2l2 Ccnb1 Pcna Ccnh Espl1 Mad2l1 Gsk3b Rbl1 Mcm3 Bub1b E2f1 Mcm4 Mcm5 Mcm6 Cdc25c Cdc25b Mcm2 Cdc25a Chek1 Chek2 Ep300 Gadd45a Orc5 Orc4 Tgfb1 Orc6 Prkdc Orc1 Orc3 Orc2 Abl1 Bub3 Cdc45 Mpeg1 Bub1 Cdc14b Cdc14a Rb1 Ccnd2 Ccnd3 Plk1 Trp53 Pttg1 Cdc7 Cdc6 Mad1l1 Smad3 Wee1 Cdk6 Smad4 Cdk4 Cdk2 Cdk1 Mdm2 E2f2 Tbc1d8 E2f3 Atm E2f4 Cdkn1a E2f5 Cdkn1b ESTROGEN SIGNALING%WIKIPATHWAYS_20260211%WP1244%MUS MUSCULUS Estrogen signaling Akt1 Mapk9 Mapk1 Ilk Nfkb1 Braf Elk1 Mnat1 Taf13 Taf12 Gtf2f2 Pik3ca Hdac8 Tbp Prkaca Fos Polr2c Gtf2a2 Gtf2b Polr2a Gtf2e1 Sos1 Polr2b Gtf2e2 Taf9 Shc2 Polr2g Polr2k Gnas Polr2h Gtf2h2 Gtf2h1 Polr2e Gtf2h4 Polr2f Gtf2h3 Chuk Gngt1 Jun Polr2i Mapk14 Ercc2 Polr2j Ccnd1 Gper1 Esr1 Ercc3 Crebbp Cdk7 Ncor1 Map2k1 Gnb1 Bcl2 Taf7 Sin3a Grb2 Taf6 Taf5 Hras Hdac3 Hdac2 Hdac5 Hdac4 Ak6 Sp1 Hdac1 Hdac7 Hdac6 Creb1 Ccnh Ep300 Ikbkb Src Ikbkg Brca1 ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP1261%MUS MUSCULUS ErbB signaling pathway Cblc Araf Nrg2 Nrg1 Mapk1 Areg Ptk2 Egfr Elk1 Btc Stat5a Gsk3b Nrg4 Nrg3 Pik3r5 Prkca Crk Sos1 Shc2 Jun Abl1 Map2k1 Grb2 Hras Mapk8 Erbb2 Erbb4 Erbb3 Eif4ebp1 Map2k7 Ereg Hbegf Mtor Src Camk2a Myc Akt3 Pak4 Nck1 Bad Egf Plcg1 Cdkn1a Gab1 Tgfa Cdkn1b SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260211%WP2140%MUS MUSCULUS Serotonin and anxiety related events Ppp3ca Plek Fos Plcd4 Nlgn1 Arc Prkcb Crh Htr2a Htr2c Crhr1 Grin2d Htr1a ELECTRON TRANSPORT CHAIN%WIKIPATHWAYS_20260211%WP295%MUS MUSCULUS Electron transport chain Sdhd Sdhc Sdhb Sdha Cox7a2l Cox6a1 Cox6a2 Uqcrfs1 Sco1 Uqcrq Coxfa4 ATP6 Atp5f1e Atp5f1d Atp5f1c mt-Atp8 Atp5mf Atp5me Cox8a Cox6b1 Ndufv2 Dmac2l Atp5mg Ndufv1 Surf1 Atp5f1b Cox15 Ndufv3 Atp5f1a Uqcrb Cox17 mt-Co2 mt-Co3 mt-Cytb Uqcrh mt-Nd4 mt-Nd5 mt-Nd6 Ndufab1 Ndufc1 mt-Co1 Ndufc2 mt-Nd1 mt-Nd2 mt-Nd3 Ndufa12 Ndufa10 Cox7b Ndufs1 Slc25a27 Ndufs3 Ndufs2 Ndufs5 Cox4i1 Slc25a4 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Atp5mc3 Atp5mc2 Cox5b-ps Slc25a14 Cox6c Ndufa1 Ucp1 Ndufa3 Ndufa2 Ndufa5 Atp5pb Ndufa7 Atp5pd Ndufa6 Ndufa9 Ndufa8 Atp5pf Ndufb10 Cox7a1 Cox7a2 Atp5po Ucp2 Ucp3 Cox5a Ndufb2 Ndufb4 Uqcrc2 Ndufb3 Ndufb6 Uqcrc1 Ndufb5 mt-Nd4l Ndufb7 Ndufb9 Atp5if1 Uqcr10 Uqcr11 Slc25a5 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2872%MUS MUSCULUS White fat cell differentiation Egr2 Mecom Ddit3 Ebf1 Gata3 Ctnna1 Klf4 Klf2 Stat5b Nr3c1 Stat5a Klf5 Zfp423 Irf4 Klf15 Gata2 Srebf1 Rara Irf3 Nr2f2 Nr1h3 Rora Pparg Cebpd Ins1 Cebpb Cebpa Tcf7l1 Wnt10b Foxo1 Creb1 Tle3 G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP298%MUS MUSCULUS G13 signaling pathway Rac1 Pik3ca Gna13 Arhgef1 Sra1 Was Arhgdib Map3k4 Arhgdig Rps6kb1 Iqgap1 Pak3 Pik3cb Pik3cd Iqgap2 Cdc42 Ppp1cb Rtkn Diaph1 Tnk2 Cfl1 Cfl2 Wasl Rhpn2 Sh3rf1 Cit Myl1 Limk1 Rock2 Mybph Pkn1 Rock1 Pfn1 Pik3r2 Mapk10 Pip4k2a Rhoa TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260211%WP1245%MUS MUSCULUS Transcriptional activation by Nfe2l2 in response to phytochemicals Pik3ca Prkca Mapk8 Nqo1 Aimp2 Gsta2 Hmox1 Nfe2l2 Ephb2 Gclc Maf Keap1 Gclm Cebpb MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP401%MUS MUSCULUS Mitochondrial long chain fatty acid beta oxidation Cpt2 Acads Acadvl Cpt1a Acsl1 Scp2 Acsl3 Acsl4 Slc25a20 Hadh Hadha Pecr Acadl Eci1 Ehhadh Acadm INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP458%MUS MUSCULUS Inflammatory response pathway Zap70 Fn1 Il2ra Il2rb Il2 Tnfrsf1b Il4 Vtn Tnfrsf1a Il5 Ifng Lamb2 Cd40lg Cd28 Lamb1 Cd86 Col1a2 Col3a1 Cd40 Col1a1 Cd80 Lama5 Il2rg Lck Il4ra Il5ra Lamc1 Lamc2 Thbs1 Thbs3 TGF BETA SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP113%MUS MUSCULUS TGF beta signaling pathway Mapk9 Nfkb1 Fos Ifng Jun Crebbp Thbs1 Fkbp1a Mapk3 Tgif1 Ltbp1 Jak1 Hras Fst Tfe3 Nog Itgb6 Zeb2 Foxh1 Serpine1 Skil Eng Lef1 Spp1 Runx3 Wnt1 Runx2 Tgfbr3 Egf Lif Smad1 Smad2 Zfyve9 Stat3 Smad9 Bambi Inhba Stat1 Tgfbr1 Smad5 Tgfbr2 Smad6 Zfp423 Smad7 Ep300 Tgfb1 Smad3 Smad4 Ctnnb1 Tnf Bmp4 FOLIC ACID NETWORK%WIKIPATHWAYS_20260211%WP1273%MUS MUSCULUS Folic acid network Xdh Fads2 Gpx2 Gpx1 Gpx4 Gpx3 Gpx6 Gsr Msrb1 Mtr Selenow Kmo Alox5 Txnrd1 Txnrd2 Cbs Cat Ptges Pnpo Ptgds Mthfr Ptgis Selenok ECTODYSPLASIN A SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260211%WP3652%MUS MUSCULUS Ectodysplasin A signaling in hair follicle development Edaradd Relb Edar Dkk4 Shh Ptch1 Nfkb1 Nfkb2 Ltb Rela Eda Sostdc1 Gli1 Dkk1 MIR 1 IN CARDIAC DEVELOPMENT%WIKIPATHWAYS_20260211%WP608%MUS MUSCULUS miR 1 in cardiac development Irx5 Hand2 Kcnd2 ELONGATION OF VERY LONG CHAIN FATTY ACIDS%WIKIPATHWAYS_20260211%WP4491%MUS MUSCULUS Elongation of very long chain fatty acids Fads2 Scd4 Fads1 Elovl2 Elovl3 Elovl4 Elovl5 Fasn Elovl1 Scd3 Scd2 Scd1 Elovl6 Elovl7 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP450%MUS MUSCULUS IL 2 signaling pathway Hsp90aa1 Crkl Akt1 Jak3 Mapk9 Foxo3 Mapk1 Jak2 Nfkb1 Stam2 Gab2 Rack1 Vav1 Nr3c1 Ifna1 Icam1 Pik3r1 Pik3ca Il2ra Syk Raf1 Il2rb Cd53 Shc1 Il2 Ptpn6 Itm2b Stam Cbl Sos1 Ptpn11 Rela Pik3cg Kras Fyn Prkcz Lyn Mapkapk2 Ptk2b Nmi Chuk Map2k2 Mknk1 Mapk14 Cish Il2rg Lck Map2k1 Bcl2 Mapk3 Grb2 Jak1 Mapk8 Ybx1 Mtor Creb1 Stat3 Stat1 Stat5b Stat5a Crk Rps6kb1 Pik3cb Pik3cd Eif4e Pik3r2 Eif3b Socs1 Socs3 Irs1 Irs2 Ets1 Shb Ets2 Plcb1 Tert SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260211%WP4344%MUS MUSCULUS Sphingolipid metabolism overview Sptlc1 Sgpl1 Cerk Sptlc2 Smpd1 Degs2 Degs1 Cers6 Plpp3 Cers4 Cers3 Plpp1 Cers2 Asah1 Sphk2 Sgms1 Sphk1 Sgms2 Kdsr Sgpp2 Ugcg Ugt8 Sgpp1 Lass1 METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260211%WP1251%MUS MUSCULUS Metapathway biotransformation Gpx5 Hs3st3a1 Chst1 Sult2a1 Chst3 Chst2 Chst5 Chst4 Chst7 Cyp24a1 Chst9 Naa30 Chst8 Cyp20a1 Gstp1 Cyp7a1 Gstz1 Hs3st4 Hs3st1 Hs3st2 Gsta3 Gsta4 Gsta1 Hs3st5 Cyp2s1 Hs3st6 Cyp4f39 Baat Naa20 Akr1d1 Kcnab1 Gstm1 Cyp51a1 Akr7a2 Kcnab2 Ephx1 Ugt1a10 Cyp1a2 Kcnab3 Gstt1 Sult1e1 Gal3st1 Cyp4v3 Cyp2r1 Gss Fmo1 Fmo3 Fmo2 Fmo5 Hs6st3 Hs6st2 Fmo4 Hs6st1 Cyp26c1 Akr1b10 Cyp21a1 Gal3st4 Gal3st3 Gpx2 Gpx1 Gpx4 Gpx3 Gsr Cyp4f3 Chst10 Chst11 Chst12 Cyp2u1 Chst13 Chst14 Cyp26b1 Gstk1 Comt Cyp1b1 Naa80 Ndst1 Ndst2 Cyp4x1 Sult1c2 Ndst3 Ndst4 Sult4a1 Cyp26a1 Cyp11b1 Cyp1a1 Cyp11b2 Gstt2 Cyp2w1 Sult1b1 Ugt1a6 Ugt1a9 Hs3st3b1 Gstm7 Ugt1a2 Gstm5 Cyp19a1 Ugt1a5 Gstm4 Cyp27b1 Cyp2f2 Gstcd Cyp11a1 Cyp4b1 Glyat Cyp8b1 Hs2st1 Tpmt Sult1a1 Hnmt Naa50 Cyp27a1 Cyp46a1 Ugt1a1 Nat8 Nat2 Cyp17a1 Cyp2e1 Ephx2 Akr1a1 Nat9 Sult2b1 Sult6b1 Ugt2a2 Nat8l Inmt Gsta2 Cyp39a1 Ugt2a3 Naa40 Gsto1 Mgst3 Gsto2 Nat10 Mgst2 Akr1b1 Mgst1 Nat14 Cyp7b1 Nnmt OXYLIPINS PATHWAYS%WIKIPATHWAYS_20260211%WP5140%MUS MUSCULUS Oxylipins pathways Ptgs2 Ltc4s Fads2 Ephx2 Gpx1 Fads1 Tbxas1 Alox8 Alox12 Cbr1 Alox5 Prxl2b Dpep1 Hpgds Lta4h Hpgd Alox15 Ptges Ptgds Ptgis Ggt1 TRANSLATION FACTORS%WIKIPATHWAYS_20260211%WP307%MUS MUSCULUS Translation factors Eif4ebp1 Eef1a2 Eef1d Eef1a1 Eef1g Eif2ak1 Eif2ak3 Eef1b Eif1a Eif5a Paip1 Eif4b Eif3j1 Etf1 Eif2ak2 Eif3i Eif4ebp2 Eif3f Eif3e Eif4g1 Eif3h Eif4g2 Eif4ebp3 Eif3a Eif4g3 Eif3d Eif3c Eif2b3 Eif2b2 Eif2b5 Eif2b4 Eif2s2 Eif2s1 Eef2k Eif2b1 Eef2 Eif1 Eif5 Eif6 Eif4a1 Eif2s3x Eif2s3y Eif4h Eif4a2 Eif4e Pabpc1 Pabpc2 Eif3g Eif3b NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2074%MUS MUSCULUS Neural crest differentiation Nfkb1 Hdac8 Dlx5 Fgf2 Wnt1 Mbp Smad1 Neurog1 Mitf Cdh7 Cdh6 Fgf8 Cdh2 Mpz Myb Nfkb2 Sox9 Sox5 Twist1 Mia Msx2 Msx3 Hoxb1 Isl1 Foxd3 Prtg Olig3 Axin1 Axin2 Olig2 Olig1 Phox2b Gfap Tfap2a Tfap2b Hdac11 Hdac10 Ets1 Wnt3a Id1 Dvl1 Dvl2 Dvl3 Sox10 Fzd3 Snai2 Snai1 Rbpj Fgfr3 Bmp7 Fgfr1 Fgfr2 Lhx2 Gjb1 Tlx2 Tcf4 Lhx5 Fgf15 Rhob Hey2 Ctbp2 Zic1 Hdac9 Ascl1 Dmbx1 Hand1 Pax3 Bmyc Notch4 Itgb1 Dct Notch1 Pax7 Notch2 Notch3 Wnt8a Col11a2 Hoxa1 Dll1 Dll3 Dll4 Gbx2 Hes1 Hes5 Col2a1 Pmp22 Zic5 Tbx6 Hdac3 Hdac2 Hdac5 Hdac4 Cdh1 Hdac1 Hdac7 Tcf7l1 Hdac6 Gsk3b Ctnnb1 Bmp4 Lhx1 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260211%WP2075%MUS MUSCULUS Alzheimer 39 s disease Mapk1 Tnfrsf1a Mapk3 Plcb4 App Plcb3 Cacna1f Cacna1c Atp2a1 Cacna1d Atp2a3 Atp2a2 Apbb1 Ide Adam17 Plcb2 Ryr3 Bad Hsd17b10 Cacna1s Grin1 Eif2ak3 Adam10 Nos1 Mapt Bace1 Mme Chp1 Chp2 Cdk5r1 Ern1 Psenen Apaf1 Gsk3b Psen1 Fadd Psen2 Atf6 Snca Grin2a Ppp3ca Ncstn Aph1a Ppp3r2 Lrp1 Ppp3r1 Calm4 Lpl Calm2 Gnaq Calml3 Grin2d Nae1 Bid Casp12 Casp8 Casp7 Ppp3cc Ppp3cb Casp9 Casp3 Capn1 Capn2 Cdk5 Il1b Fas Apoe Itpr3 Grin2c Itpr2 Trp53 Grin2b Itpr1 Tnf Plcb1 ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP252%MUS MUSCULUS Androgen receptor signaling pathway Ube3a Rad54l2 Akt1 Pxn Bag1 Mapk1 Hmgb2 Psmc3ip Cav1 Igf1 Mmp1a Fhl2 Ywhah Gtf2f2 Ghr Pou2f1 Rac3 Rnf14 Calr Pou2f2 Nr0b2 Plagl1 Spdef Rela Etv5 Svil Il6st Ncor2 Tmf1 Gtf2h1 Hspa1a Rnf4 Appl1 Ncoa2 Jun Ncoa1 Ncoa4 Ncoa3 Ccnd1 Nsd1 Pnrc1 Pak6 Crebbp Sry Cdk7 Runx1 Casp1 Map2k1 Pten Stub1 Tgfb1i1 Sin3a Rchy1 Tgif1 Ran Hipk3 Sp1 Runx2 Stat3 Egfr Cdk9 Nr2c2 Nr3c1 Raf1 Ar Slc25a4 Cox5b-ps Nr0b1 Esr1 Esr2 Nr5a1 Ccne1 Hdac1 Ccnh Cdc25b Ep300 Prmt1 Casp8 Casp7 Casp3 Rb1 Trp53 Atf2 Nrip1 Pias3 Uxt Smad3 Pias4 Ctdp1 Kat5 Smad4 Ube2i Kat7 Gtf2f1 Cdk1 Src Ctnnb1 Pias1 Mdm2 Pias2 Tle5 Patz1 Brca1 Flna Cdc37 Pa2g4 Ranbp9 Il6 Senp1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260211%WP1498%MUS MUSCULUS Dopaminergic neurogenesis Stat3 Ascl1 Tgfb1 Gli1 Fgf8 Shh Gbx2 Nr4a2 Ddc Neurog2 Aldh1a1 En2 Ret En1 Nkx2-2 Nkx6-1 Gli2 Sox2 Th Slc18a2 Otx2 Msx1 Wnt1 Slc6a3 Lmx1a Lmx1b Neurod1 Pitx3 Foxa2 Cdkn1c FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260211%WP3675%MUS MUSCULUS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling Jkamp Pld1 Igfbp3 Akt1 Igfbp2 Igfbp5 Ilk Igfbp4 Nfkb1 Igfbp1 Pdk1 Igf1 Mstn Igfbp7 Igfbp6 Tnfsf9 Trim63 Prkab1 Acvr2b Igf1r Tnfrsf1a Rps6kb1 Itgb1 Pten Smad3 Mtor Ppargc1a Irs1 Tnf Foxo1 Smad2 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP336%MUS MUSCULUS Fatty acid biosynthesis Acsl1 Acsl3 Acsl4 Hadh Mecr Pcx Fasn Ech1 Echdc3 Echdc1 Echdc2 Scd1 Decr1 Acly Echs1 Acss2 Acaa2 Pecr Acsl5 Acsl6 Acacb Acaca WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP539%MUS MUSCULUS Wnt signaling pathway Akt1 Mapk9 Mapk1 Sall1 Fhl2 Tbp Jun Ccnd1 Mapk3 Mapk8 Lef1 Camk2a Wnt1 Runx2 Prkca Prkcb Map3k7 Dkk1 Sox1 Wnt5a Tax1bp3 Cxxc4 Skp1 Ppp2ca Myb Daam1 Sox9 Magi3 Ror2 Crybb2 Btrc Senp2 Vangl2 Ruvbl1 Nlk Dab2 Wnt2 Wnt4 Axin1 Wnt3 Axin2 Jup Fzd4 Fzd6 Fzd8 Bcl9 Tfap2a Dlg1 Dlg2 Dlg4 Cul1 Wnt3a Pin1 Tcf3 Dvl1 Csnk2a2 Dvl2 Csnk2a1 Dvl3 Mark2 Ctbp1 Sfrp2 Sfrp1 Csnk2b Rac1 Csnk1d Csnk1e Sumo1 Lrp6 Csnk1a1 Lrp5 Camk2g Raf1 Nkd1 Tcf4 Camk2d Camk2b Arrb2 Arrb1 Wnt7a Ctbp2 Brd7 Map1b Ctnnbip1 Ankrd6 Apc Mapk8ip1 Fzd1 Frat2 Frat1 Fzd2 Hipk2 Fzd5 Fzd7 Fzd9 Nr5a1 Cdh1 Gsk3b Cdc25c Lrp1 Ep300 Smad3 Pias4 Smad4 Cdk1 Ctnnb1 Pax2 Rhoa G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260211%WP413%MUS MUSCULUS G1 to S cell cycle control E2f6 Mnat1 Prim1 Pole2 Tfdp2 Cdkn2b Cdkn2c Cdkn2d Ccng2 Ccnd1 Rpa1 Rpa2 Rpa3 Cdk7 Ccna1 Mcm7 Ccne1 Ccne2 Myc Cdkn2a Tfdp1 Pole Pkmyt1 Cdkn1c Pola2 Pcna Ccnh Rbl1 Mcm3 E2f1 Mcm4 Mcm5 Mcm6 Mcm2 Cdc25a Gadd45a Orc5 Orc4 Orc6 Orc1 Orc3 Orc2 Cdc45 Rb1 Ccnd2 Ccnd3 Trp53 Wee1 Cdk6 Cdk4 Cdk2 Cdk1 Mdm2 E2f2 E2f3 Atm Prim2 E2f4 Cdkn1a E2f5 Cdkn1b GLUTATHIONE AND ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP730%MUS MUSCULUS Glutathione and one carbon metabolism Gpx2 Gpx1 Gpx4 Gpx3 Gsr Mtr Cbs Mthfr Ahcyl2 Bhmt Shmt2 Dnmt3a Shmt1 Gss G6pdx Mat2b Ggt5 Ahcy Mtrr Idh1 Amt Chdh Anpep Dnmt3b Dnmt1 Cth Mat1a Oplah Gclc Gclm Ggt1 SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260211%WP108%MUS MUSCULUS Selenium metabolism selenoproteins Sars1 Sepsecs Fabp1 Selenom Selenon Nfkb1 Selenoo Selenop Dio1 Selenos Secisbp2 Selenot Dio2 Gpx2 Dio3 Pou2f1 Gpx1 Selenov Gpx4 Sephs2 Gpx3 Sephs1 Gpx6 Fos Trnau1ap Pstk Msrb1 Selenow Rela Txnrd1 Txnrd2 Selenok Jun Cth Nfe2l2 Selenbp2 Selenbp1 Txnrd3 Sp1 Rpl30 Sp3 Eefsec Crem Scly Sars2 Selenoh Selenoi FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP1269%MUS MUSCULUS Fatty acid beta oxidation Cpt2 Acads Acadvl Cpt1a Acsl1 Acsl3 Acsl4 Slc25a20 Hadh Hadhb Gk Pnpla2 Gcdh Lpl Crat Decr1 Tpi1 Acat1 Gk2 Echs1 Lipc Acss2 Gpd2 Lipe Lipf Acsl5 Acsl6 Cpt1b Chkb Dld Hadha Acadl Eci1 Acadm HYPOXIA DEPENDENT DIFFERENTIATION OF MYOBLASTS%WIKIPATHWAYS_20260211%WP5025%MUS MUSCULUS Hypoxia dependent differentiation of myoblasts Hif1an Bhlhe40 Egln1 Myh1 Vegfa Hif1a Myf6 Myf5 Notch1 Cdkn1a Mapk14 Myog Cdkn1b GPCRS PEPTIDE%WIKIPATHWAYS_20260211%WP234%MUS MUSCULUS GPCRs peptide Ccr2 Galr2 Galr3 Cckbr Galr1 Npy4r Cx3cr1 Lhcgr Avpr2 Sstr4 Ccr10 Sstr3 Sstr2 Mc1r Sstr1 Avpr1b Mc5r Tacr1 Avpr1a Tacr2 C5ar1 Fpr1 Nmbr Bdkrb2 Bdkrb1 Tshr Agtr1a Agtr1b Ccr1 Oxtr Npy2r Npy6r Grpr Mc3r Ccr1l1 Ccr7 Mc4r Oprk1 Ghsr Ednra Cckar Ednrb Cxcr2 Oprl1 Npy1r Cxcr3 Gnrhr Npy5r Ntsr2 Ntsr1 Trhr Brs3 Fpr-s1 Sstr5 Mc2r Oprd1 Fshr Agtr2 C3ar1 Ccr9 Cxcr4 Oprm1 Cxcr5 Tacr3 Ccr8 Cxcr6 Ccr6 Ccr5 Ccr4 Ccr3 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260211%WP6%MUS MUSCULUS Integrin mediated cell adhesion Akt1 Pxn Mapk1 Ilk Cav1 Braf Rac3 Sos1 Itgb2 Mapk7 Pak6 Mapk6 Mapk4 Akt2 Map2k1 Tns1 Mylk2 Sorbs1 Tln1 Grb2 Vcl Vasp Arhgef7 Hras Shc3 Itga7 Itga8 Itga5 Itgb6 Itga6 Itga9 Itga3 Itga4 Itga1 Itga2 Capn9 Akt3 Itga10 Itga11 Pak4 Capn5 Cav3 Cav2 Capn7 Capn6 Capn3 Itgax Araf Itgav Pdpk1 Rac2 Itgae Ptk2 Itgal Vav3 Rap1a Rap1b Itgad Itgb8 Itgb7 Vav2 Itga2b Crk Itgb4 Itgb5 Actn1 Itgb3 Dock1 Map2k6 Bcar1 Map2k5 Pak1 Rho Csk Pak2 Mapk12 Git2 Map2k3 Rapgef1 Zyx Capns1 Capn10 Capn11 Rac1 Raf1 Shc1 Fyn Itgb1 Map2k2 Selenop Pak3 Cdc42 Capn1 Capn2 Rock2 Rock1 Pik3r2 Mapk10 Src Itgam ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260211%WP240%MUS MUSCULUS Alanine and aspartate metabolism Gad1 Got1 Got2 Gad2 Gpt Abat Ass1 Carns1 Asl Aspa Agxt Adsl Dars1 Pcx Crat BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260211%WP522%MUS MUSCULUS Biogenic amine synthesis Gad1 Chat Gad2 Ddc Aanat Tph1 Maoa Pnmt Hdc Asmt Dbh Pah Th Ache Comt EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260211%WP544%MUS MUSCULUS Exercise induced circadian regulation Bmal1 Gstm3 Herpud1 Ppp1r3c Nckap1 Gfra1 Vapa Ugp2 Sumo1 Sf3a3 Pigf Erc2 Dazap2 Qki Cldn5 Ppp2cb Eif4g2 H2bc7 Nr1d1 Cbx3 H2-DMa Rbpms Zfr Etv6 Hspa8 Per1 Pura Nr1d2 Gstp2 Klf9 Tab2 Tubb4a Azin1 Ncoa4 Myf6 Ucp3 Psma4 Idi1 Btg1 Dnaja1 Sumo3 Cry1 Cebpb Cry2 Stbd1 G0s2 Clock Tob1 COMPLEMENT ACTIVATION CLASSICAL PATHWAY%WIKIPATHWAYS_20260211%WP200%MUS MUSCULUS Complement activation classical pathway C2 C3 C4a C5 C1s1 C6 C7 C9 Cd55 C1qc C1qb C1qa C1ra Masp1 C8b C8a SPINAL CORD INJURY%WIKIPATHWAYS_20260211%WP2432%MUS MUSCULUS Spinal cord injury Gdnf Ccr2 Mapk1 Ccl2 Nos2 Il2 Fos Tacr1 Il4 Ifng Tlr4 Ccnd1 Fkbp1a Mapk3 Bdnf Myc Mbp Grin1 Mag Prkca E2f1 Ppp3ca Sox9 Ltb Pla2g2a Gfap Pla2g6 Icam1 Rhob C5 Aqp4 Col2a1 Pdyn Gja1 Nr4a1 Zfp36 Omg Pirb Plxna2 Anxa1 Ngfr Prb1a Klk8 Rtn4 Selp Bcan Chst11 Egr1 Efnb2 Ptpra Col4a1 Cspg4 Nox4 Ltb4r1 Btg2 Nos1 Ptprz1 Slit1 Slit3 Rhoc Rgma Vcan Sema6a Mmp12 Tnfsf13b Gap43 Arg1 Mmp9 Epha4 Rtn4r Ccng1 Ntn1 Tnfsf13 Pla2g5 Cd47 Cxcl1 Cxcl2 Ncan Fcgr2b Gadd45a Acan Il1a Xylt1 Tgfb1 Vim Il1r1 Casp3 Il1b Rb1 Rock2 Trp53 Cxcl10 Cdk4 Cdk2 Cdk1 Slit2 Tnf Rhoa Il6 E2f5 ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP435%MUS MUSCULUS One carbon metabolism Atic Mtr Mthfr Mthfd1l Dhfr Mtfmt Folh1 Tyms Mthfd1 Mthfd2 Ahcyl2 Ftcd Bhmt Gart Tcn2 Shmt2 Ehmt2 Dnmt3a Aldh1l1 Shmt1 Ehmt1 Mthfs Mat2b Ahcy Mtrr Amt Dnmt3b Dnmt1 Mat1a BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260211%WP460%MUS MUSCULUS Blood clotting cascade Fgb F8a1 Fga F10 Vwf F12 F11 F2 F5 Fgg F7 Plat F8 F9 F13b Plau Serpine1 Serpinf2 Serpinb2 Plg SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260211%WP1266%MUS MUSCULUS SIDS susceptibility pathways Slc6a4 Cc2d1a Avp Gata3 Tph2 Phox2a Nfkb1 Nfya Nkx3-1 Vipr2 Nr3c1 Foxm1 Adcyap1r1 Cdca7l Il6ra Vipr1 Tlx3 Ar Fev Chrna4 Gnb3 Ascl1 Rora C4a Hes1 Hes5 Ddc Ybx1 En1 Nkx2-2 Rest Ctcf Sp1 Cav3 Lmx1b Pou3f2 Htr1a Creb1 Gata2 Htr2a Ep300 Tph1 Maoa Ret Ppargc1a Il10 Phox2b Ppargc1b Ryr2 Deaf1 Scn5a Ece1 Adcyap1 Tnf Kcnh2 Chrnb4 Chrnb2 Il6 Kcnq1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260211%WP164%MUS MUSCULUS Glutathione metabolism Gstt1 Gss G6pdx Ggt5 Gpx2 Gpx1 Gpx4 Idh1 Gstt2 Gpx3 Gsr Anpep Chac2 Ggct Gstm2 Gstm7 Oplah Gsta1 Dpep1 Gclc Gclm Ggt1 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260211%WP207%MUS MUSCULUS Nucleotide GPCRs Adora2b Adora1 Adora2a Adora3 Lpar6 P2ry6 P2ry4 P2ry2 Tmigd3 P2ry1 Lpar4 Ltb4r1 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260211%WP1983%MUS MUSCULUS Splicing factor NOVA regulated synaptic proteins Mapk9 Camk2g Prkcz Rap1gap Kcnma1 Clasp1 Cask Dab1 Kcnj6 Epb41l2 Clstn1 Stxbp2 Mapk4 Epb41l3 Cdh2 Cadm3 Epb41l1 Cadm1 Gabbr2 Gabrg2 Kcnq2 Stx2 Grin2b Map4 Neo1 Plcb4 Agrn Atp2b1 Chl1 Ank3 Gphn Terf2ip Snw1 Ntng1 Epb41 Csn3 Aplp2 Grik2 Ncdn Efna5 Cav2 Grin1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP201%MUS MUSCULUS Ptf1a related regulatory pathway Fgf10 Ptf1a Nkx6-1 Rbpj Ctnnb1 Hes1 Kat2b Rbpjl Notch1 Pdx1 Prox1 DELTA NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP265%MUS MUSCULUS Delta Notch signaling pathway Akt1 Mapk1 Jak2 Rbpj Pik3r1 Hey2 Rela Ascl1 Ncor2 Notch4 Notch1 Jun Notch2 Notch3 Lck Dll1 Ncor1 Dll4 Hes1 Sin3a Mapk3 Hes5 App Snw1 Hdac2 Lef1 Adam17 Hdac1 Egf Skp2 Smad1 Adam10 Stat3 Fhl1 Hivep3 Mfng Hey1 Numb Egfr Ccn3 Psenen Cntf Sap30 Gsk3b Psen1 Mef2c Hes6 Spen Tle1 Psen2 Maml3 Zfpm1 Numbl Fbxw7 Ncstn Cntfr Pofut1 Aph1b Dtx1 Itch Maml1 Ep300 Maml2 Ring1 Furin Jag2 Jag1 Cirsr Nfkbia Magea1 Cntn1 Yy1 Lfng Wdr12 Skp1 Trp53 Pik3r2 Smad3 Smad4 Cdk2 Cul1 Tcf3 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260211%WP1270%MUS MUSCULUS Endochondral ossification Akt1 Vegfa Fgfr3 Igf1 Bmp7 Fgfr1 Ghr Prkaca Plat Thra Enpp1 Col2a1 Fgf2 Hdac4 Spp1 Chst11 Runx3 Runx2 Cdkn1c Stat1 Stat5b Mef2c Mmp9 Igf1r Acan Tgfb1 Ddr2 Fgf18 Ihh Ctsl Ptch1 Hmgcs1 Alpl Sox9 Col10a1 Sox5 Sox6 Adamts1 Mmp13 Ift88 Adamts5 Adamts4 Scin Frzb Pth1r Pth Nkx3-2 Plau Tgfb2 Cab39 Slc38a2 Pthlh Kif3a Serpinh1 Igf2 Gli3 Bmpr1a Timp3 Bmp6 Cst5 Mgp ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260211%WP396%MUS MUSCULUS ACE inhibitor pathway Ren1 Ren2 Ace Nos3 Kng1 Agtr2 Agt Bdkrb2 Agtr1a ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260211%WP4265%MUS MUSCULUS Ethanol metabolism resulting in production of ROS by CYP2E1 Nfe2l2 Map2k1 Maff Mafg Sp1 Prkcd Mafk Cyp2e1 Map2k2 Mapk8 EICOSANOID LIPID SYNTHESIS MAP%WIKIPATHWAYS_20260211%WP4335%MUS MUSCULUS Eicosanoid lipid synthesis map Pla2g6 Pla2g5 Ptgs2 Alox5 Ptges Pgs1 Ptgds Pla2g4b Pla2g4a OXIDATIVE STRESS AND REDOX PATHWAY%WIKIPATHWAYS_20260211%WP4466%MUS MUSCULUS Oxidative stress and redox pathway Gpx5 Ptgs2 Gstm3 Rac1 Ncf1 Ncf2 Gstp1 Ncf4 Slco1a1 G6pd2 Ggct Gls Gstm2 Grxcr2 Grxcr1 Gsta3 Prdx2 Gstp2 Gsta4 Slc6a5 Gsta1 Prdx3 Prdx4 Prdx5 Slc6a9 Prdx1 Gpx8 Gpx7 Pgd Abcc2 Gstm1 Abcc5 Gstt3 Foxp3 Gstt1 Lap3 Ctla4 Nrf1 Slc7a11 Txn Gss Slco2a1 G6pdx Gstm6 Slc1a2 Ggt5 Slc1a5 Prdx6b Prdx6 Idh1 S100a9 S100a8 Cd44 Anpep Ggt7 Ggt6 Idh2 Sod3 Sod2 Oplah Sod1 Hpgds Cyba Txnrd3 Cybb Gstk1 Gpx2 Gpx1 Gpx4 Gstt2 Gpx3 Gpx6 Gsr Gstm7 Txnrd1 Gstm5 Txnrd2 Cbs Gstm4 Gsta2 Nfe2l2 Alox5 Gsto1 Gclc Mgst3 Gsto2 Keap1 Gclm Mgst2 Mgst1 Ptgs1 Ggt1 STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260211%WP216%MUS MUSCULUS Striated muscle contraction Tnnc1 Tcap Dmd Actg1 Acta1 Acta2 Jsrp1 Actc1 Tpm4 Smpx Tpm3 Tpm2 Tpm1 Neb Tnni3 Tnni2 Tnni1 Myl4 Myom1 Des Myh3 Actn2 Mybpc1 Actn3 Mybpc2 Myl2 Mybpc3 Vim Myl3 Myh8 Actn4 Myh4 Myl9 Myom2 Myh6 Myh7 Myh1 Myl1 Tnnt3 Tnnt2 Tnnt1 Casq2 Ttn Tnnc2 Tmod1 HEART DEVELOPMENT%WIKIPATHWAYS_20260211%WP2067%MUS MUSCULUS Heart development Fgf10 Vegfa Mapk1 Hey1 Mef2c Hey2 Ptpn11 Hand1 Notch1 Bhlhe40 Srf Fgf8 Tbx10 Shh Smyd1 Nkx2-5 Bmp10 Nfatc4 Nfatc1 Hand2 Vegfc Nfatc3 Vegfb Nfatc2 Tbx20 Isl1 Irx4 Erbb3 Tbx5 Pitx2 Tbx2 Foxh1 Bmpr2 Smad4 Bmp2 Gata6 Gata4 Ctnnb1 Bmpr1a Foxc2 Smad1 Bmp4 Foxa2 Foxc1 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260211%WP1258%MUS MUSCULUS Homologous recombination Rpa1 Pold2 Pold1 Pold4 Pold3 Rad51 Rad50 Rad52 Brca2 Nbn Atm Mre11a Rad54b EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260211%WP4347%MUS MUSCULUS Eicosanoid metabolism via cyclooxygenases COX Cyp4a12a Pla2g6 Cyp4f14 Ptgs2 Ptgfr Cyp4a12b Ptgdr2 Cyp4a10 Ptgr2 Ptgr1 Acox1 Acox2 Acox3 Pla2g4b Ptgir Pla2g4a Acaa1a Pla2g5 Cyp4f3 Ppard Tbxas1 Prxl2b Hpgd Ptges Ptgds Akr1b1 Ptgis Tbxa2r Ehhadh Ptgs1 Ptgdr EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP1249%MUS MUSCULUS EPO receptor signaling Stat3 Akt1 Mapk1 Jak2 Stat1 Pdk1 Stat5b Stat5a Raf1 Epo Shc1 Rasa1 Epor Ptpru Ptprc Sos1 Pik3cg Map2k2 Cish Map2k1 Mapk3 Grb2 Src Socs1 Irs1 Irs2 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260211%WP385%MUS MUSCULUS Myometrial relaxation and contraction pathways Nfkb1 Ywhah Gnb3 Fos Atf1 Prkd1 Rgs4 Rgs5 Rgs2 Rgs3 Gnas Rgs1 Crcp Slc8a1 Rgs9 Rgs6 Gngt1 Oxtr Rgs7 Jun Plcg2 Prkcq Actb Prkcg Prkch Prkce Rxfp2 Rxfp1 Atf5 Gnb1 Mylk2 Atf4 Atf3 Calm3 Pkib Calca Grk5 Atf6b Grk4 Pkia Grk6 Sfn Pkig Cnn1 Dgkz Gnb2 Gnb4 Camk2a Gabpb1 Sp1 Rln1 Gnb5 Gng11 Gng12 Gng13 Plcg1 Ryr1 Ywhaq Oxt Creb1 Adm Ramp1 Gabpa Igfbp3 Ywhae Igfbp2 Ywhab Igfbp5 Guca2b Igfbp4 Guca2a Igfbp1 Lpar1 Creb3 Cald1 Prkacb Igfbp6 Ywhaz Prkca Prkar1a Prkar1b Rgs20 Plcd1 Rgs17 Rgs18 Rgs19 Prkcb Gng3 Crh Gng2 Gng5 Gng4 Crhr1 Rgs14 Gng7 Rgs16 Gng8 Cacnb3 Prkar2a Prkar2b Adcy3 Ackr3 Adcy4 Rgs10 Rgs11 Adcy1 Ackr5 Adcy2 Corin Adcy7 Ramp3 Ramp2 Adcy8 Adcy5 Adcy6 Adcy9 Pde4b Ets2 Nos3 Maff Prkcd Camk2g Camk2d Camk2b Arrb2 Arrb1 Prkcz Pde4d Gja1 Plcb3 Ywhag Atp2a3 Atp2a2 Ryr3 Nos1 Actg1 Acta1 Actc1 Myl4 Gnaq Myl2 Il1b Itpr3 Itpr2 Itpr1 Atf2 Gsto1 Ryr2 Il6 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP407%MUS MUSCULUS Kit receptor signaling pathway Fes Crkl Akt1 Mapk1 Jak2 Vav1 Pik3r1 Raf1 Shc1 Rasa1 Ptpn6 Epor Ptpru Cblb Cbl Sos1 Ptpn11 Pik3cg Fyn Lyn Cish Map2k1 Grb2 Hras Bad Plcg1 Stat3 Stat1 Stat5b Stat5a Vav2 Prkca Crk Prkcb Ep300 Mitf Abl1 Stap1 Grb10 Socs5 Socs4 Socs6 Matk Csf2rb Cltc Sh3kbp1 Pik3r2 Fgr Hck Dok1 Rps6ka1 Tnfrsf10b Kit Btk Spred1 Mpdz Src Spred2 Socs1 Inpp5d Grb7 Grap Yes1 Kitlg Plce1 Sh2b2 Tec ALPHA 6 BETA 4 INTEGRIN SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP488%MUS MUSCULUS Alpha 6 beta 4 integrin signaling pathway Clca1 Clca2 Akt1 Rpsa Erbin Rac1 Plec Dsp Mmp7 Dst Prkcd Cd151 Ywhah Lama1 Lama2 Pik3r1 Pik3ca Lama3 Trp73 Ar Mst1r Shc1 Met Col17a1 Lamb3 Pik3cg Lamb2 Fyn Lamb1 Lama5 Lamc1 Lamc2 Grb2 Erbb2 Eif4ebp1 Itga6 Sfn Mtor Bad Smad2 Ywhae Ywhab Ptk2 Egfr Ywhaz Prkca Itgb4 Ntn1 Pak1 Pik3cb Pik3cd Vim Eif6 Rtkn Abl1 Casp3 Eif4e Pik3r2 Smad3 Src Irs1 Irs2 Yes1 Rhoa Cdkn1a G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260211%WP232%MUS MUSCULUS G protein signaling pathways Prkcd Prkaca Gnb3 Prkd3 Prkd1 Akap7 Akap8 Akap5 Kras Akap6 Akap3 Gnas Prkcz Akap4 Pde7b Gnaz Pde7a Akap10 Akap11 Akap12 Gngt1 Akap9 Akap13 Prkcq Kcnj3 Nras Prkcg Prkci Prkch Rras Pde4c Prkce Gnai2 Pde4d Gnai1 Gnai3 Gna12 Gnb1 Gna11 Gng10 Gna15 Gna14 Gnao1 Gnal Hras Slc9a1 Gngt2 Plcb3 Pde8a Gnb2 Pde8b Gnb5 Gng11 Gng12 Gng13 Prkacb Prkca Prkar1a Prkar1b Gna13 Ppp3ca Arhgef1 Pde1b Pde1c Pde1a Prkcb Gng3 Gng5 Gng4 Gnaq Gng7 Gng8 Prkar2a Prkar2b Adcy3 Ppp3cc Adcy4 Adcy1 Adcy2 Adcy7 Akap1 Adcy8 Adcy5 Adcy6 Adcy9 Itpr1 Pde4a Pde4b Rhoa BURN WOUND HEALING%WIKIPATHWAYS_20260211%WP5056%MUS MUSCULUS Burn wound healing Nos3 Vegfa Acta1 Lama1 Gja1 Nos2 Flii Nlrp3 Tgfbrap1 Pecam1 Prodh2 Hbegf Tgfb1 Tnf Col1a1 ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP1264%MUS MUSCULUS Estrogen metabolism Cyp1b1 Sult1a1 Cyp1a2 Sult1e1 Ugt1a1 Cyp1a1 Nqo1 Ugt1a6 Ugt1a9 Ugt1a2 Gsta1 Gstm1 Comt MIR 127 IN MESENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP3991%MUS MUSCULUS miR 127 in mesendoderm differentiation Smad4 Acvr1 Nodal T Acvr2a Cfc1 T2 Lefty2 Smad2 Foxa2 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260211%WP553%MUS MUSCULUS Calcium regulation in cardiac cells Ywhah Gnb3 Calr Prkd1 Rgs4 Rgs5 Rgs2 Rgs3 Gnas Rgs1 Slc8a1 Rgs9 Rgs6 Gngt1 Rgs7 Prkcq Prkcg Prkch Prkce Gnb1 Fkbp1a Calm3 Pkib Grk5 Grk4 Pkia Atp2b1 Grk6 Sfn Pkig Gnb2 Gnb4 Camk2a Gnb5 Gng11 Gng12 Gng13 Ryr1 Ywhaq Ywhae Ywhab Prkacb Ywhaz Prkca Prkar1a Prkar1b Rgs20 Rgs17 Rgs18 Rgs19 Prkcb Gng3 Gng2 Gng5 Gng4 Rgs14 Gng7 Rgs16 Gng8 Cacnb3 Prkar2a Prkar2b Adcy3 Adcy4 Rgs10 Rgs11 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adrb2 Adrb1 Adcy9 Prkcd Gjb1 Camk2g Camk2d Camk2b Arrb2 Arrb1 Prkcz Gnaz Kcnj3 Gnai2 Gnai1 Gnai3 Gna11 Gnao1 Gja1 Plcb3 Cacna1c Ywhag Cacna1d Atp2a3 Atp2a2 Cacna1e Ryr3 Cacna1a Casq2 Cacna1b Cacna1s Gja3 Gja5 Gja4 Gja8 Slc8a3 Adra1b Adra1a Adrb3 Adra1d Fxyd2 Gjc1 Chrm1 Chrm3 Chrm2 Gjc2 Chrm5 Chrm4 Gjb2 Gjb4 Gjb3 Gjb6 Gjb5 Casq1 Atp2b2 Atp2b3 Gnaq Gjd2 Camk4 Atp1a4 Anxa6 Camk1 Kcnb1 Kcnj5 Pln Atp1b1 Cacnb1 Atp1b3 Atp1b2 Itpr3 Itpr2 Itpr1 Ryr2 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP493%MUS MUSCULUS Mapk signaling pathway Traf2 Ecsit Akt1 Tmem37 Mapk9 Ngf Mapk1 Rps6ka3 Nfkb1 Mink1 Braf Sos2 Elk1 Ppm1b Acvr1c Ppm1a Ptpn7 Ptpn5 Ntf4 Dusp5 Rasa1 Prkaca Dusp4 Fos Dusp1 Acvr1b Dusp7 Dusp10 Dusp6 Mapk13 Taok2 Taok1 Casp6 Casp2 Hspa1a Gck Cd14 Mapkapk5 Mos Map2k4 Jun Ntrk1 Mapk14 Mapk8ip3 Il1r2 Map3k11 Prkcg Map3k12 Mapk7 Prkch Map3k13 Mapk6 Map3k14 Mapk4 Akt2 Casp1 Map2k1 Atf4 Mapk3 Grb2 Bdnf Mapk8 Fgf4 Map2k7 Myc Akt3 Nf1 Egf Rac2 Tgfbr1 Egfr Rap1a Tgfbr2 Rap1b Mef2c Crk Ppp3ca Prkcb Map2k6 Map2k5 Pak1 Pak2 Mapk12 Map3k7 Nlk Tgfb2 Crkl Rac1 Prkcd Raf1 Arrb2 Arrb1 Hspa8 Kras Prkcz Tab2 Mapkapk2 Map2k2 Nras Gna12 Nr4a1 Mapt Ddit3 Cdc25b Ppp3r2 Pla2g5 Map3k4 Ppp3r1 Gadd45a Il1a Tgfb1 Cdc42 Il1r1 Casp8 Casp7 Ppp3cc Ppp3cb Casp9 Casp3 Map3k8 Srf Map3k6 Map3k5 Il1b Map3k20 Fas Map3k1 Pla2g10 Rasgrp4 Rasgrp1 Jund Trp53 Rasa2 Atf2 Max Stmn1 Mapk10 Stk3 Map4k4 Map4k3 Tgfb3 Fasl Ikbkb Pdgfrb Hspb1 Hspb2 Pdgfb Rasgrf2 Traf6 Map4k1 Hspa5 Ikbkg Flna Tab1 Tnf Daxx Ppp5c Ptprr Mras MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP1560%MUS MUSCULUS MicroRNAs in cardiomyocyte hypertrophy Akt1 Mapk1 Nfkb1 Rac1 Agt Igf1 Lrp6 Fgfr2 Lrp5 Pik3r1 Pik3ca Raf1 Camk2d Hdac9 Pik3cg Il6st Myef2 Fzd1 Fzd2 Chuk Map2k4 Map2k2 Mapk14 Cish Mapk7 Map3k14 Rcan1 Mapk4 Cdk7 Ikbke Akt2 Map2k1 Edn1 Mylk3 Prkg1 Mapk3 Mylk Nppb Nppa Ctf1 Mapk8 Fgf2 Map2k7 Mtor Hdac5 Hdac4 Plcb2 Hdac7 Egf Lif Stat3 Pdpk1 Nrg1 Gsk3b Cdk9 Ppp3ca Igf1r Eif2b5 Prkcb Map2k6 Map2k5 Pik3cb Pik3cd Tgfb1 Map2k3 Ppp3cb Wnt5a Nfatc4 Rock2 Rock1 Pik3r2 Ikbkb Pla2g2a Gata4 Ctnnb1 Ikbkg Tab1 Tnf Wnt3a Rhoa Dvl1 FOCAL ADHESION%WIKIPATHWAYS_20260211%WP85%MUS MUSCULUS Focal adhesion Akt1 Pxn Mapk9 Mapk1 Ilk Cav1 Braf Elk1 Igf1 Fn1 Pik3ca Rac3 Vtn Sos1 Lamb2 Itgb2 Lamb1 Col1a2 Col3a1 Col1a1 Jun Lama5 Actb Ccnd1 Mapk7 Pak6 Mapk6 Mapk4 Lamc1 Akt2 Map2k1 Lamc2 Thbs1 Pten Mylk2 Thbs3 Bcl2 Tln1 Mylk Grb2 Vcl Vasp Mapk8 Tnc Shc3 Erbb2 Ppp1r12a Itga7 Tnn Itga8 Tnr Itga5 Itgb6 Tnxb Itga6 Col5a2 Itga9 Col5a3 Itga3 Hgf Itga4 Col5a1 Pgf Itga2 Arhgap5 Spp1 Akt3 Myl6 Itga10 Reln Itga11 Pak4 Lama4 Thbs2 Cav3 Bad Thbs4 Cav2 Egf Blk Srms Txk Pdgfc Itgax Araf Pdgfd Itgav Chad Pdpk1 Pdgfra Rac2 Pdgfa Itgae Col4a4 Ptk2 Itgal Egfr Tesk2 Tnk1 Rap1a Col4a2 Rap1b Ptk6 Itgad Col4a6 Itgb8 Ibsp Itgb7 Pik3r5 Parvb Pelo Itga2b Crk Flt1 Itgb4 Birc3 Itgb5 Birc2 Actn1 Itgb3 Pik3r4 Col11a1 Dock1 Map2k6 Vegfd Bcar1 Pak5 Map2k5 Col6a2 Pak1 Farp2 Lamc3 Styk1 Pak2 Pip5k1c Mapk12 Map2k3 Rapgef1 Zyx Fgr Hck Crkl Vegfa Rac1 Vav1 Lama1 Lama2 Pik3r1 Lama3 Raf1 Shc1 Met Rhob Lamb3 Pik3cg Fyn Itgb1 Map2k2 Col11a2 Col2a1 Col4a1 Actg1 Selenop Gsk3b Pak3 Pik3cb Pik3cd Cdc42 Diaph1 Tnk2 Capn1 Ccnd2 Rock2 Ccnd3 Vegfc Vwf Rock1 Vegfb Pik3r2 Pdgfrb Src Pdgfb Flna Rhoa Itgam HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP193%MUS MUSCULUS Hepatocyte growth factor receptor signaling Stat3 Crkl Pxn Mapk1 Ptk2 Elk1 Rap1a Rap1b Pik3ca Raf1 Crk Rasa1 Fos Met Dock1 Ptpn11 Sos1 Pak1 Ptk2b Itgb1 Map2k2 Jun Rapgef1 Map2k1 Pten Mapk3 Grb2 Hras Mapk8 Hgf Itga1 Src Map4k1 Gab1 IL 7 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP297%MUS MUSCULUS IL 7 signaling pathway Stat3 Akt1 Jak3 Foxo3 Mapk1 Stat1 Stam2 Stat5b Stat5a Gsk3b Pik3r1 Raf1 Shc1 Stam Cbl Cblb Sos1 Fyn Lyn Bcl2l11 Ptk2b Muc1 Mcl1 Map2k2 Irf1 Bax Il7r Il2rg Map2k1 Rb1 Ccnd2 Mapk3 Grb2 Cltc Jak1 Hras Ccna2 Cdk4 Cdk2 Irs1 Irs2 Bad Blk Foxo1 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1496%MUS MUSCULUS Oxidative damage response Traf2 Nfkb1 Pcna Apaf1 Tnfrsf1b C5ar1 Mapk13 Gadd45a C1qb C1qa Cdc42 C1ra Map2k4 Tnk2 Cr2 C2 Casp9 Traf3 Casp3 Map3k9 C5 Bag4 Bak1 C1s1 Traf1 Nfkbie Cycs Map3k1 Bcl2 Cyct Tdp2 C1qc Mapk10 C3ar1 Traf6 Bad Tnf Cdkn1a Cdkn1b Cdkn1c MIR 193A AND MVP IN COLON CANCER METASTASIS%WIKIPATHWAYS_20260211%WP3979%MUS MUSCULUS mir 193a and MVP in colon cancer metastasis Ccnd1 Myc Ccnd2 Mvp Caprin1 G3bp1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260211%WP2573%MUS MUSCULUS Primary focal segmental glomerulosclerosis FSGS Cldn1 Col4a5 Akt1 Synpo Lims1 Kirrel2 Ilk Kirrel3 Fat1 Parva Lrp6 Cd151 Lrp5 Camk2b Vtn Lamb2 Fyn Itgb1 Tlr4 Notch1 Cd80 Lama5 Tln1 Vcl Agrn Itga3 Nck1 Lmx1b Plcg1 Ywhaq Cdkn1c Itgav Mme Col4a3 Pcna Col4a4 Ptk2 Itgb4 Itgb3 Tgfb1 Jag1 Vim Actn4 Dkk1 Cdh2 Ctsl Mki67 Cr1l Trpc6 Utrn Ptpro Nphs2 Nphs1 Cd2ap Dag1 Krt8 Dnm1 Ctnnb1 Scarb2 Inf2 Pax2 Myh9 Irf6 Plaur Podxl Myo1e Plce1 Cdkn1a Smarcal1 Wt1 Cdkn1b TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260211%WP79%MUS MUSCULUS Tryptophan metabolism Cyp1b1 Ube3a Cyp4f14 Aldh1a2 Aldh3a2 Hadh Aldh2 Aldh9a1 Cyp1a1 Wars1 Tdo2 Cyp2j6 Cyp2c55 Aadat Ubr5 Aox1 Ogdh Afmid Gcdh Maob Cyp19a1 Aoc1 Acat1 Dhcr24 Haao Echs1 Cat Kynu Prmt1 Cyp2f2 Rnf25 Acmsd Ido1 Cyp1a2 Cyp2e1 Ddc Aanat Tph1 Aldh1a1 Inmt Asmt Mdm2 Hsd17b10 Cyp7b1 HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP116%MUS MUSCULUS Hedgehog signaling pathway Stk36 Ptch2 Sap18 Crebbp Sufu Ccnb1 Ihh Shh Dyrk1a Ptch1 Gas1 Sin3a Gli2 Smo Cdk1 Igf2 Gli3 Rab23 Dhh Gli1 Hhip IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP373%MUS MUSCULUS IL 3 signaling pathway Akt1 Pxn Mapk9 Mapk1 Nfkb1 Pik3ca Syk Prkaca Tnfrsf1b Atf1 Sos1 Mapk14 Lck Mapk7 Map2k1 Bcl2 Mapk3 Grb2 Vcl Jak1 Hras Mapk8 Bad Gab1 Creb1 Stat3 Rac2 Ywhab Stat1 Ptk2 Rap1a Stat5a Ywhaz Prkca Crk Prkcb Pak1 Bcl2l11 Rapgef1 Bax Ppp2ca Matk Csf2rb Hck Dnm1 Inpp5d Socs3 Id1 Tec Fes Crkl Jak2 Rac1 Gab2 Rack1 Vav1 Pik3r1 Raf1 Shc1 Ptpn6 Rara Cbl Ptpn11 Kras Fyn Lyn Mapkapk2 Cish Rxra Spi1 Socs2 Fcer2a Gata1 Il3ra Il3 Rps6kb2 Bmx Stat6 Birc5 Kcnip3 Slc2a1 Tyk2 Mmp2 Bcl2l1 Gsk3a Selp Foxo1 Stat5b Gsk3b Mmp9 Gata2 Chek1 Pik3cd Cdc42 Atf2 Pik3r2 Hspb1 Src Mras GLOBO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5305%MUS MUSCULUS Globo series sphingolipid metabolism B3galnt1 B3galt5 Fut2 Gbgt1 MIR302 367 PROMOTING CARDIOMYOCYTE PROLIFERATION%WIKIPATHWAYS_20260211%WP2904%MUS MUSCULUS miR302 367 promoting cardiomyocyte proliferation Yap1 Mob1b Lats2 Mst1 IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP387%MUS MUSCULUS IL 6 signaling pathway Akt1 Pxn Mapk1 Nfkb1 Il6ra Fos Sos1 Il6st Cd40 Map2k4 Jun Ncoa1 Mapk14 Crebbp Map2k1 Mapk3 Grb2 Jak1 Hras Mapk8 Erbb2 Erbb3 Eif4ebp1 Bad Plcg1 Gab1 Stat3 Stat1 Ptk2 Stat5a Cdk9 Map2k6 Map3k7 Ppp2ca Eif4e Nlk Fgr Hck Btk Inpp5d Socs3 Tec Hsp90aa1 Fes Foxo3 Jak2 Rac1 Gab2 Prkcd Vav1 Ppp2cb Pik3r1 Raf1 Ar Shc1 Ptpn11 Fyn Lyn Mapkapk2 Ptk2b Map2k2 Bmx Tyk2 Hdac1 Cebpb Ppp2r3a Foxo1 Ppp2r2c Ppp2r2b Mapt Ptpa Ppp2r2a Ppp2r1b Ppp2r1a Hnf1a Cdk5r1 Foxo4 Stat5b Rps6ka2 Sgk1 Gsk3b Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Inppl1 Eif2a Ppp2r5e Map3k4 Rps6kb1 Ep300 Casp9 Casp3 Cdk5 Rb1 Pik3r2 Hspb1 Daxx Il6 HYPOXIA DEPENDENT PROLIFERATION OF MYOBLASTS%WIKIPATHWAYS_20260211%WP5024%MUS MUSCULUS Hypoxia dependent proliferation of myoblasts Akt1 Vegfa Myf5 Igf1 Mstn Calca Trim63 Fbxo32 Smad3 Ddit4 Myod1 Tsc2 Hgf Tsc1 Fgf1 Mtor Rheb Smad2 Myog APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260211%WP166%MUS MUSCULUS Apoptosis modulation by HSP70 Casp9 Casp3 Nfkb1 Fas Map3k1 Apaf1 Fadd Mapk10 Tnfrsf1a Casp6 Aifm1 Casp2 Ripk1 Hspa1a Bid Casp8 Casp7 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP449%MUS MUSCULUS Complement and coagulation cascades Kng1 Fgb Plat C5ar1 Bdkrb1 C1qb C1qa C1ra Masp1 C2 C3 C5 C1s1 C6 C7 C9 Cd55 C1qc Serpine1 Serping1 Mbl1 C4bpa Masp2 Tfpi Cfb F3 Serpina5 Cr2 C8g Cfd Cd59a Cfh F2r Cfi Klkb1 Proc Serpind1 Cd46 F10 Thbd Vwf Pros1 F12 Serpinc1 Cr1l F11 A2m F2 Cpb2 F5 Cd55b F7 F8 F9 F13b Plau Serpinf2 C3ar1 Plaur Plg ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260211%WP1770%MUS MUSCULUS One carbon metabolism and related pathways Gpx5 Baat Gpx7 Bhmt Shmt2 Dnmt3a Shmt1 Gss Chdh Cth Sod3 Mat1a Sod2 Sod1 Gad1 Pld1 Gpx2 Gpx1 Gpx4 Gpx3 Gpx6 Gsr Mtr Cbs Mthfr Chkb Dhfr Pcyt1a Tyms Pemt Gad2 Chka Bcat1 Bcat2 Pcyt1b Pcyt2 Csad Dmgdh Bhmt2 Dnm1 Cept1 Gclc Mat2a Gnmt Ahcyl1 Gclm Etnk2 Etnk1 Chpt1 Agxt2 Sardh Cdo1 GENE REGULATORY NETWORK MODELLING SOMITOGENESIS %WIKIPATHWAYS_20260211%WP2852%MUS MUSCULUS Gene regulatory network modelling somitogenesis Mesp2 Lfng Hes7 Ripply2 Fgf8 Dll1 Hes1 Epha4 Wnt3a Notch1 Tbx6 GLYCOGEN METABOLISM%WIKIPATHWAYS_20260211%WP317%MUS MUSCULUS Glycogen metabolism Ppp2r2b Ptpa Ppp2r2a Gbe1 Ppp2r1b Phkb Ppp2r1a Gys1 Gys2 Ugp2 Phka1 Phka2 Ppp2r5d Gyg1 Gsk3b Ppp2r5c Pygb Ppp2r5b Ppp2cb Phkg1 Ppp2r5a Phkg2 Agl Pygl Pygm Ppp2r5e Calm2 Ppp2ca Pgm1 Calm3 Gsk3a Ppp2r3a Ppp2r2c BMP SIGNALING PATHWAY IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260211%WP3663%MUS MUSCULUS BMP signaling pathway in eyelid development Fgf10 Mapk9 Sfrp1 Shh Egfr Smad5 Map3k1 Mapk3 Fgfr2 Dkk2 Pitx2 Inhbb Smad4 Foxc2 Jun Smad1 Bmp4 Notch1 Tgfa Foxc1 IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP37%MUS MUSCULUS IL 1 signaling pathway Akt1 Irak4 Mapk1 Nfkb1 Irak2 Irak1 Il1rap Peli1 Ptpn11 Myd88 Sqstm1 Rela Irak3 Nfkbib Prkcz Tollip Tab2 Elp1 Il1a Sirpa Il1rn Chuk Il1r1 Nfkbia Map3k7 Il1r2 Capns1 Capn1 Map3k14 Casp1 Map2k1 Il1b Mapk3 Mapk8 Traf6 Tab1 Plcg1 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP18%MUS MUSCULUS Heme biosynthesis Cpox Uros Urod Ppox Alad Alas1 Alas2 Hmbs Fech AMINO ACID METABOLISM%WIKIPATHWAYS_20260211%WP662%MUS MUSCULUS Amino acid metabolism Pkm Hadh Wars1 Acaa1a Tdo2 Gls Ogdh Gsta4 Lars2 Bhmt Pdhx Tat Asns Gss Aldh7a1 Vars1 Acss1 Farsb Cs Ddc Suclg1 Idh1 Aldh1a1 Pdk4 Hibch Sds Arg2 Aldh18a1 Gpt2 Cth Cad Th Dlst Mccc1 Ldha Mars2 Sms Mpst Oat Glud1 Pycr1 Odc1 Cps1 Adh7 Prodh Adh5 Srm Rars1 Adh4 Tpo Adh1 Pck1 Aoc3 Arg1 Fh Mdh1 Mdh2 Eprs1 Iars1 Fah Gsr Hal Pcx G6pc2 Ppm1l Hmgcl P4ha2 Hibadh Aco2 Hmgcs2 Mmut Acly Cbs Glul Otc Sdhd Auh Sdha Dld Pdha1 Got1 Got2 Ftcd Hnmt Ass1 Asl Tph1 Maoa Bcat1 Pnmt Hdc Dbh Gclm Ehhadh Acadm PDGFR ALPHA AND STMN1 COOPERATE TO EXACERBATE CYTOTOXIC EFFECTS OF VINBLASTINE%WIKIPATHWAYS_20260211%WP4398%MUS MUSCULUS PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine Pdgfra Stmn1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260211%WP2084%MUS MUSCULUS SREBF and miR33 in cholesterol and lipid homeostasis Ppara Ppargc1a Mtor Srebf2 Hmgcr Nr1h3 Sirt1 Ldlr Med15 Srebf1 Sirt6 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260211%WP3857%MUS MUSCULUS Wnt signaling in kidney disease Dvl3 Fzd3 Mapk9 Csnk1a1 Gsk3b Lrp5 Wnt7a Apc Fzd1 Fzd2 Fzd5 Fzd7 Fzd9 Wnt11 Lrp4 Wnt6 Wnt5a Wnt7b Wnt5b Wnt9b Wnt10a Invs Wnt2b Wnt16 Btrc Mapk8 Mapk10 Wnt2 Nlrp3 Wnt4 Wnt3 Axin1 Fzd4 Fzd6 Fzd8 Ctnnb1 Wnt1 Wnt3a Kitlg Rhoa Wnt10b Dvl1 Dvl2 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260211%WP4345%MUS MUSCULUS Glycerolipids and glycerophospholipids Pcyt1a Pld1 Pemt Cds1 Ptdss1 Gpat4 Plpp1 Pla2g1b Ptdss2 Pnpla3 Pisd Dgat2 Cdipt Gpam Pnpla2 Pcyt2 Dgat1 Dgkz Agpat4 Crls1 Etnk1 Chpt1 Chkb CIRCULATING MONOCYTES AND CARDIAC MACROPHAGES IN DIASTOLIC DYSFUNCTION%WIKIPATHWAYS_20260211%WP4474%MUS MUSCULUS Circulating monocytes and cardiac macrophages in diastolic dysfunction Ccr2 Ccl2 Il10 Spp1 SEROTONIN RECEPTOR 2 AND STAT3 SIGNALING%WIKIPATHWAYS_20260211%WP2079%MUS MUSCULUS Serotonin receptor 2 and STAT3 signaling Stat3 Jak2 Htr2a Gnaq MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260211%WP3626%MUS MUSCULUS Microglia pathogen phagocytosis pathway Lat Rac2 Rac1 Vav3 Vav1 Pik3ca Pik3r1 Syk Vav2 Ncf1 Rac3 Ncf2 Ncf4 Ptpn6 Pik3cg Fcer1g Pik3cb Lyn Itgb2 Pik3cd C1qb C1qa Plcg2 C1qc Pik3r2 Hck Pik3c3 Tyrobp Siglec12 Cyba Fcgr1 Cybb Nckap1l Pik3c2a Arpc1b Trem3 Trem2 Pik3r6 Itgam Trem1 ADIPOGENESIS GENES%WIKIPATHWAYS_20260211%WP447%MUS MUSCULUS Adipogenesis genes Gata3 Igf1 Il6st Ncor2 Ncoa2 Ncoa1 Ncor1 Cebpd Serpine1 Sp1 Wnt1 Lif Creb1 Stat3 Stat1 Pck1 Stat5a Mef2c E2f1 Cntfr Wnt5b Twist1 Pnpla3 Frzb Scd1 Socs1 Socs3 Irs1 Irs2 Ptgis Dvl1 Gh Nampt Ins2 Irs4 Trib3 Celf1 Agt Ahr Irs3 Lifr Nr3c1 Prlr Bscl2 Agrp Mif Retn Lmna Ndn Id3 Rara Cisd1 Pck2 Nsg1 Bmp3 Wwtr1 Bmp1 Hmga1 Fzd1 Plin1 Plin2 Ucp1 Adipoq Nr2f1 Nr1h3 Epas1 Slc2a4 Sfrp4 Ppard Rbl2 Rora Gadd45b Ppara Mef2d Zmpste24 Pparg Fabp4 Osm Lpin3 Rxra Lpin2 Lpin1 Dlk1 Rxrg Mixl1 Mef2a Klf7 Klf6 Mef2b Lep Stat6 Spock1 Stat2 Agpat2 Gdf10 Ins1 Cebpb Cebpa Cyp26b1 Wnt10b Foxo1 Tle3 Egr2 Ddit3 Ebf1 Hnf1a Stat5b Klf5 Cyp26a1 Rbl1 Klf15 Gata2 Srebf1 Lpl Gadd45a Mbnl1 Tgfb1 Lipe Cfd Hif1a Fas Rb1 Nrip1 Smad3 Bmp2 Ppargc1a Gata4 Ctnnb1 Tnf Foxc2 E2f4 Bmp4 Il6 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP350%MUS MUSCULUS p38 Mapk signaling pathway Traf2 Ddit3 Stat1 Rac1 Tgfbr1 Elk1 Pla2g4a Shc1 Map2k6 Ripk1 Mapkapk2 Cdc42 Map2k4 Mknk1 Mapk14 Map3k7 Mef2d Map3k9 Map3k5 Map3k1 Grb2 Hras Atf2 Max Hmgn1 Tradd Tgfb2 Rasgrf1 Hspb1 Rps6ka5 Myc Daxx Creb1 GPCRS SMALL LIGAND%WIKIPATHWAYS_20260211%WP353%MUS MUSCULUS GPCRs small ligand Ptgfr Cnr1 Lpar1 Ptgir S1pr1 S1pr2 Mtnr1b Mtnr1a Cnr2 Ptger4 Ptger2 Ptafr Ptger3 Ptger1 S1pr3 Tbxa2r S1pr4 Ptgdr OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260211%WP454%MUS MUSCULUS Osteoclast signaling Ctsk Ifnb1 Tnfsf11 Ifnar1 Atp6v1g1 Tnfrsf11b Tnfrsf11a Gpr68 Acp5 Slc9a1 Itgb3 Pdgfb Spp1 Trpv5 EBV LMP1 SIGNALING%WIKIPATHWAYS_20260211%WP1243%MUS MUSCULUS EBV LMP1 signaling Hsp90aa1 Ifnb1 Map3k14 Mapk1 Nfkb1 Traf1 Nfkb2 Pdlim7 Map3k3 Ccl20 Ccl5 Mapk8 Irak1 Ikbkb Tradd Rela Traf6 Ikbkg Chuk Tnf Map3k7 POLYOL PATHWAY%WIKIPATHWAYS_20260211%WP1265%MUS MUSCULUS Polyol pathway Akr1b1 Sord Aldob Khk APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260211%WP3592%MUS MUSCULUS ApoE and miR 146 in inflammation and atherosclerosis Rela Spi1 Nfkb2 Apoe Traf6 Tlr4 Irak1 Tlr2 REGULATION OF PGC1A EXPRESSION BY A GSK3B TFEB SIGNALING AXIS IN SKELETAL MUSCLE%WIKIPATHWAYS_20260211%WP4763%MUS MUSCULUS Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle Tfeb Ppargc1a Gsk3b EGFR1 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP572%MUS MUSCULUS EGFR1 signaling pathway Rbbp7 Eps15l1 Akt1 Pxn Reps2 Ralbp1 Mapk1 Rps6ka3 Ctnnd1 Abi1 Cav1 Sos2 Pebp1 Elk1 Pkn2 Zpr1 Pik3ca Ptpn5 Rasa1 Fos Dusp1 Atf1 Cblb Prkd1 Sos1 Appl1 Jun Plcg2 Mapk14 Mapk7 Map3k14 Map2k1 Mapk3 Grb2 Sin3a Tgif1 Jak1 Hras Mapk8 Map2k7 Camk2a Myc Sp1 Nck1 Eef1a1 Cav2 Egf Plcg1 Smad2 Gab1 Creb1 Cblc Stat3 Araf Pld1 Ywhab Stat1 Egfr Vav3 Stat5a Ptk6 Prkca Vav2 Prkar1a Crk Prkcb Bcar1 Itch Map2k5 Pak1 Csk Rgs16 Snrpd2 Map2k3 Grb10 Sh3kbp1 Rps6ka1 Krt8 Dnm1 Socs1 Socs3 Grb7 Crkl Jak2 Rac1 Plec Gab2 Vav1 Pik3r1 Raf1 Shc1 Ptpn6 Cbl Ptpn11 Pik3cg Kras Prkcz Ptk2b Map2k2 Nras Prkci Gja1 Stat2 Rps6ka5 Hdac1 Cebpb Cebpa Foxo1 Stat5b Rps6ka2 Map3k3 Snca Inppl1 Sh2d3c Grb14 Map3k4 Stxbp1 Elk4 Eps8 Ralb Krt7 Eps15 Pik3cb Ripk1 Map3k2 Pik3cd Dok2 Ap2a1 Cdc42 Hat1 Pitpna Rab5a Pld2 Tnk2 Errfi1 Casp9 Usp6nl Pik3c2b Wasl Ralgds Wnk1 Rfxank Arf4 Map3k1 Hip1 Sh3bgrl Shoc2 Ndufa13 Jund H3f4 Nck2 Asap1 Pik3r2 Git1 Sh3gl3 Smad3 Epn1 Elf3 Klf11 Sh3gl2 Plscr1 Ceacam1 Tnip1 Src Htt Appl2 Ptpn12 Mta2 Krt18 Krt17 Mcf2 Ptprr Reps1 Spry2 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260211%WP456%MUS MUSCULUS GPCRs class B secretin like Adgre5 Vipr2 Ghrhr Adcyap1r1 Gipr Adgrg2 Gcgr Vipr1 Adgre1 Adgrl2 Sctr Adgrl3 Adgrl4 Pth1r Adgrl1 Glp2r Pth2r Calcrl Glp1r Crhr2 Crhr1 Calcr DEREGULATION OF RENIN ANGIOTENSIN SYSTEM BY SARS COV INFECTION%WIKIPATHWAYS_20260211%WP4965%MUS MUSCULUS Deregulation of renin angiotensin system by SARS CoV infection Ace Agtr2 Ace2 Agtr1a WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260211%WP723%MUS MUSCULUS Wnt signaling pathway and pluripotency Mapk9 Ctnnd1 Nfya Prkd1 Pafah1b1 Ppp2r2d Pou5f1 Fosl1 Nanog Jun Hnf1b Zbtb33 Prkcq Fbxw2 Ccnd1 Nkd2 Prkcg Racgap1 Prkch Ppm1j Prkce Crebbp Sox2 Lef1 Myc Wnt1 Prkca Prkcb Ldlr Map3k7 Wnt11 Wnt5a Wnt6 Wnt7b Wnt5b Wnt9b Wnt10a Ppp2ca Wnt2b Wnt16 Nlk Foxd3 Wnt2 Wnt4 Axin1 Wnt3 Axin2 Fzd4 Fzd6 Fzd8 Wnt3a Dvl1 Dvl2 Dvl3 Ctbp1 Fzd3 Csnk1e Mmp7 Prkcd Lrp6 Lrp5 Ppp2cb Nkd1 Tcf4 Wnt7a Ctbp2 Apc Prkcz Fzd1 Frat1 Fzd2 Fzd5 Fzd7 Ppard Fzd9 Prkci Cd44 Tcf7l1 Wnt10b Ppp2r2c Ppp2r2b Ptpa Ppp2r2a Ppp2r1b Ppp2r1a Hnf1a Gsk3b Ppp2r5c Ppp2r5e Ep300 Ccnd2 Ccnd3 Trp53 Mapk10 Plau Ctnnb1 Rhoa LUNG FIBROSIS%WIKIPATHWAYS_20260211%WP3632%MUS MUSCULUS Lung fibrosis Ccr2 Ccl2 Dsp Igf1 Bmp7 Il4 Il5 Eln Il13 Fgf7 Ccn2 Edn1 Mecp2 Atp11a Parn Sftpa1 Fam13a Csf2 Calca Csf3 Mt2 Ccl11 Elmod2 Fgf2 Dpp9 Sftpc Ccl4 Mmp2 Ccl3 Hgf Skil Cma1 Muc5b Stn1 Spp1 Cysltr2 Timp1 Rtel1 Cebpb Ptx3 Cxcl15 Egf Tgfa Pdgfa Smad7 Mmp9 Ccl5 Cxcl2 Fgf1 Tgfb1 Il1b Grem1 Hmox1 Plau Nfe2l2 Pdgfb Il12b Tnf Il6 Ccr3 Tert PROTEASOME DEGRADATION%WIKIPATHWAYS_20260211%WP519%MUS MUSCULUS Proteasome degradation Ifng H2ax Psma3 Psma6 Psma5 Psme3 Psma2 Psma1 Psme2 Psme1 Psmd12 Psmd11 Psmd10 Ube2b Psmd13 Psmb10 Uchl4 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Ube2d3 Ube2d1 Psma7 Psmc6 Psmc5 Psmc2 Rpn2 Psmc1 Psmc4 Psmc3 Rpn1 Uba7 Ubb Ubc Psmb9 Psmb8 Psmd7 H2az1 Psmd6 Psmd9 Uchl1 Psmd8 Psmd3 Psmd2 Psmd5 Psmd4 Ube2d2a Uba1 Hist1h2an H2-Q10 Psma4 B CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP274%MUS MUSCULUS B cell receptor signaling pathway Akt1 Mapk1 Braf Sos2 Elk1 Zap70 Syk Rasa1 Dusp4 Ptprc Cblb Prkd1 Sos1 Dusp6 Rela Rel Chuk Jun Plcg2 Mapk14 Prkcq Lck Prkce Mapk4 Cdk7 Map2k1 Rps6 Bcl2 Mapk3 Grb2 Mapk8 Nck1 Plcg1 Blk Gab1 Creb1 Stat3 Pdpk1 Stat1 Ptk2 Bcl6 Vav2 Crk Ppp3ca Prkcb Bcar1 Csk Pip5k1c Bcl2l11 Nfkbia Rapgef1 Bax Map3k7 Cr2 Stap1 Hck Dok1 Cd72 Rps6ka1 Sla2 Chst15 Pdk2 Btk Cd81 Gtf2i Actr2 Actr3 Inpp5d Dok3 Rasgrp3 Arpc1b Pip4k2b Pip4k2c Cd79a Cd79b Sh2b2 Bcl10 Tec Pik3ap1 Crkl Arpc3 Arpc2 Cd19 Arpc5 Arpc4 Itk Gab2 Rap2a Prkcd Dapp1 Vav1 Bank1 Cd22 Atp2b4 Pik3r1 Raf1 Plekha2 Plekha1 Shc1 Hcls1 Card11 Ptpn6 Lat2 Blnk Lime1 Cbl Lcp2 Ptpn11 Pik3cg Ptpn18 Cd5 Fyn Sh3bp2 Cmtm3 Lyn Nedd9 Mapkapk2 Pip5k1b Ptk2b Pip5k1a Map2k2 Ccna2 Ccne1 Gsk3a Hdac5 Hdac7 Foxo1 Gsk3b Was Hnrnpk Ppp3r1 Rps6kb1 Fcgr2b Casp7 Ppp3cb Casp9 Rb1 Ccnd2 Ccnd3 Nfatc1 Itpr2 Nfatc3 Itpr1 Atf2 Nfatc2 Pik3r2 Pip4k2a Cdk6 Ikbkb Cdk4 Cdk2 Ctnnb1 Map4k1 Ikbkg Rhoa KENNEDY PATHWAY%WIKIPATHWAYS_20260211%WP1771%MUS MUSCULUS Kennedy pathway Pcyt1a Sgpl1 Pemt Chka Ptdss1 Ptdss2 Pisd Pcyt1b Pcyt2 Cept1 Etnk2 Etnk1 Chpt1 Chkb MONOAMINE GPCRS%WIKIPATHWAYS_20260211%WP570%MUS MUSCULUS Monoamine GPCRs Adra1b Adra1a Adrb3 Adra1d Chrm1 Chrm3 Chrm2 Chrm5 Chrm4 Drd1 Drd2 Htr2a Htr2c Drd5 Adra2a Adra2c Adra2b Htr4 Hrh1 Htr6 Htr7 Hrh2 Htr2b Drd3 Drd4 Htr1f Htr1b Htr5b Htr5a Adrb2 Adrb1 Htr1d Htr1a OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260211%WP238%MUS MUSCULUS Osteoblast signaling Pth1r Tnfsf11 Pth Pdgfra Tnfrsf11b Pdgfrb Bglap2 Slc17a2 Fgf23 Col1a1 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260211%WP1274%MUS MUSCULUS Oxidation by cytochrome P450 Cyp1b1 Cyp4x1 Cyp24a1 Cyp26a1 Cyp11b1 Cyp1a1 Cyp11b2 Cyp20a1 Cyp2w1 Cyp7a1 Cyp4f3 Cyp19a1 Cyp2s1 Cyp27b1 Cyp4f39 Cyp2f2 Cyp11a1 Cyp4b1 Cyp51a1 Cyp8b1 Cyp1a2 Cyp4v3 Cyp27a1 Cyp2r1 Cyp46a1 Cyp17a1 Cyp2e1 Cyb5r4 Cyb5r3 Cyb5r2 Cyb5r1 Cyp26c1 Cyb5a Cyb5b Cyp21a1 Cyp39a1 Por Cyp2u1 Cyp26b1 Cyp7b1 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260211%WP1242%MUS MUSCULUS Non homologous end joining Xrcc6 Xrcc5 Xrcc4 Nhej1 Rad50 Prkdc Mre11a PARKINSON 39 S DISEASE%WIKIPATHWAYS_20260211%WP3638%MUS MUSCULUS Parkinson 39 s disease Prkn Septin5 Gpr37 Ube2l6 Ube2j2 Ube2l3 Ube2j1 Mapk11 Apaf1 Park7 Eprs1 Snca Mapk13 Casp6 Casp2 Mapk12 Casp7 Uba7 Mapk14 Ubb Casp9 Casp3 Uchl1 Cycs Ddc Uba1 Ccne1 Ccne2 Th Atxn2 Pink1 Slc6a3 Syt11 Lrrk2 Htra2 Ube2g2 Ube2g1 Sncaip BDNF PATHWAY%WIKIPATHWAYS_20260211%WP2152%MUS MUSCULUS BDNF pathway Mapk4 Rac1 Bcl2 Frs2 Ntrk2 Bdnf Trp53 Shc1 Plat Ngfr Serpine1 Plg Cdc42 Bax Creb1 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY %WIKIPATHWAYS_20260211%WP4690%MUS MUSCULUS Sphingolipid metabolism integrated pathway Cers5 Lass1 Sptlc1 Sgpl1 Cerk Sptlc2 Smpd1 Degs2 Degs1 Cers6 Plpp3 Cers4 Cers3 Plpp1 Cers2 Asah1 Sphk2 Sgms1 Sphk1 Sgms2 Kdsr Sgpp2 Ugcg Ugt8 Sgpp1 LAC PHE PATHWAY%WIKIPATHWAYS_20260211%WP5240%MUS MUSCULUS Lac Phe pathway Abcc5 Cndp2 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260211%WP683%MUS MUSCULUS Leptin and adiponectin Lepr Cpt1a Adipoq Adipor2 Adipor1 Lep Prkab1 Prkaa1 Acaca Prkag1 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260211%WP2141%MUS MUSCULUS Serotonin and anxiety Adra1a Grm1 Ppp3ca Camk2b Plek Fos Plcd4 Pomc Arc Gabra1 Prkcb Trpv1 Crh Htr2a Htr2c Eef2 Fmr1 Htr1a EICOSANOID METABOLISM VIA LIPOXYGENASES LOX %WIKIPATHWAYS_20260211%WP4348%MUS MUSCULUS Eicosanoid metabolism via lipoxygenases LOX Cyp4a12a Cyp4f14 Ltc4s Cyp4a12b Cyp4a10 Ptgr2 Ptgr1 Acox1 Acox2 Acox3 Gpx1 Acaa1a Gpx4 Dpep2 Cyp4f3 Ggt5 Ephx2 Alox12 Alox5 Dpep1 Lta4h Mgst3 Alox15 Hpgd Mgst2 Ehhadh Ggt1 HYPOXIA DEPENDENT SELF RENEWAL OF MYOBLASTS%WIKIPATHWAYS_20260211%WP5023%MUS MUSCULUS Hypoxia dependent self renewal of myoblasts Myh1 Hif1a Hey1 Myf5 Hes1 Hey2 Myod1 Hsp90b1 Notch1 Cdkn1a Pax7 Foxo1 Myog CHOLESTEROL BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP103%MUS MUSCULUS Cholesterol biosynthesis Msmo1 Hmgcs1 Fdps Idi1 Nsdhl Mvk Dhcr7 Fdft1 Hmgcr Lss Sqle Pmvk Sc5d Cyp51a1 Mvd SIGNAL TRANSDUCTION OF S1P RECEPTOR%WIKIPATHWAYS_20260211%WP57%MUS MUSCULUS Signal transduction of S1P receptor Smpd2 Racgap1 Mapk7 Pik3c2g Akt1 Mapk6 Asah2 Gnai2 Mapk1 Gnai1 Akt2 Gnai3 Mapk3 Sphk2 Plcb3 Sphk1 S1pr1 S1pr2 S1pr5 Akt3 Mapk12 S1pr3 COMPREHENSIVE IL 17A SIGNALING%WIKIPATHWAYS_20260211%WP5242%MUS MUSCULUS Comprehensive IL 17A signaling Rbbp4 Tjp1 Akt1 Atox1 Igf1 Fn1 Sqstm1 Rela Col1a1 Ccn2 Bcl2 Mylk Ccl4 Ccl3 Mtor Cxcl15 Gng12 Ppp1r14b Smad2 Stat3 Pdgfa Stat1 Egfr Adh1 Smad6 Smad7 Prkacb Psmc6 Mki67 Pik3c3 Plaur Arpc3 Ptgs2 Arpc2 Snai2 Snai1 Arpc5 Jak2 Rac1 Pura C3 Zmpste24 C7 Mcm7 Sod2 Acta1 Acta2 Pcna Tnfsf13b Gap43 Mmp9 Mcm3 Ccl5 Mcm4 Mcm5 Mcm6 Mcm2 Cxcl1 Cxcl2 Pak3 Tgfb1 Anxa6 Cdc42 Orc1 Orc2 Casp3 Serbp1 Hyou1 Il1b Cacybp Uggt1 Becn1 Plch1 Cpne1 Nasp Trp53 Nucks1 Rras2 Hmgb1 Fbn1 Smad3 Hbb-bh1 Blmh Angpt1 Plau Mmp14 Npm1 Mmp3 Upf1 Samhd1 Pdgfb Map1lc3a Map1lc3b Pon3 Atrx Hspa1b Hbb-bs Rhoa Cxcl5 Il6 Hbbt1 Rab10 DYSREGULATED MIRNA TARGETING IN INSULIN PI3K AKT SIGNALING%WIKIPATHWAYS_20260211%WP3855%MUS MUSCULUS Dysregulated miRNA targeting in insulin PI3K AKT signaling Crkl Flot2 Prkx Exoc7 Col4a2 Pik3r1 Raf1 Sos1 Rheb Bcl2l11 Col1a2 Col3a1 Prkar2a Col1a1 Acaca Bcl2 Ccnd2 Eif4e2 Mapk3 Fasn Col5a3 Mtor Socs1 Bad Cdkn1b MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260211%WP2928%MUS MUSCULUS miR 222 in exercise induced cardiac growth Hmbox1 Hipk1 Hipk2 Cdkn1b FOCAL ADHESION PI3K AKT MTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP2841%MUS MUSCULUS Focal adhesion PI3K Akt mTOR signaling pathway Ngf Igf1 Fn1 Il6ra Ghr Il2ra Il2rb Il2 Gnb3 Vtn Lpar6 Lamb2 Lamb1 Ppp2r2d Col1a2 Lpar4 Col3a1 Col1a1 Lama5 Il2rg Il4ra Lamc1 Fgf7 Lamc2 Thbs1 Pten Thbs3 Mapk3 Eif4e2 Jak1 Csf3 Tnc Tnn Tnr Itgb6 Tnxb Col5a2 Col5a3 Hgf Col5a1 Pgf Spp1 Reln Lama4 Thbs2 Efna5 Thbs4 Pdgfc Fgf10 Pdgfd Chad Pdgfra Pdgfa Col4a4 Col4a2 Col4a6 Ibsp Pelo Flt1 Igf1r Pik3r4 Col11a1 Vegfd Col6a2 Lamc3 Acaca Il7r Fgf18 Ppp2ca Cab39 Irs1 Irs2 Hsp90aa1 Jak3 Foxo3 Vegfa Nos3 Kdr Jak2 Ifna1 Pik3r1 Raf1 Pik3cg Kras Map2k2 Il3ra Rps6kb2 Slc2a1 Ppp2r3a Ppp2r2c Ppp2r2b Ppp2r1b Ppp2r1a Ppp2r5d Gsk3b Ppp2r5c Ppp2r5b Ppp2r5a Prkaa1 Ppp2r5e Ddit4 Tsc2 Tsc1 Hsp90b1 Fgf1 Rheb Lipe Pik3c2g Hif1a F2r Vegfc Vegfb Angpt1 Ikbkb Mdm2 Ikbkg Cdkn1a Cdkn1b Itgam Rab10 Ifnb1 Akt1 Mapk1 Gys1 Gys2 Prkaa2 Rab11b Phlpp1 Phlpp2 Pik3ca Ppp2r3d Ppp2r3c Epo Nos2 Tcl1 Ulk1 Epor Insr Mtcp1 Pik3ip1 Tbc1d1 Sos1 Lpar5 Fgfr4 Gng14 Fgf16 Rptor Itgb2 Fgf17 Fgf14 Ifnab Gngt1 Prl Osmr Fgf12 Fgf13 Fgf11 Hif3a Fgf20 Fgf21 Fgf22 Akt2 Ifna4 Map2k1 Ifna5 Gnb1 Atf4 Ifna6 Rps6 Ifna7 Grb2 Ifna2 Ifna9 Foxa1 Strada Hras Rab8a Atf6b Comp Itga7 Csf3r Itga8 Fgf2 Fgf6 Itga5 Rab2a Eif4ebp1 Itga6 Fgf4 Eif4e1b Itga9 Fgf3 Fgf9 Itga3 Hsp90ab1 Itga4 Csf1 Gnb2 Mtor Creb3l3 Itga2 Gnb4 Creb3l4 Akt3 Creb3l1 Itga10 Creb3l2 Itga11 Gng11 Crtc2 Gng12 Csf1r Bad Gng13 Akt1s1 Egf Stk11 Cab39l Efna4 Creb1 Efna1 Itgax Efna2 Itgav Efna3 Pdpk1 Flt4 Eif4b Pfkfb4 Itgae Ptk2 Pfkfb3 Itgal Egfr Pfkfb1 Slc2a2 Lpar1 Slc2a3 Creb3 Lpar3 Itgad Angpt2 Itgb8 Pik3r5 Lpar2 Itgb7 Angpt4 Creb5 Itga2b Epha2 Itgb4 Ifna13 Itgb5 Ifna14 Ifna11 Itgb3 Mlst8 Gng3 Ifnar2 Gng2 Tcl1b4 Gng5 Tcl1b1 Gng4 Rab14 Tek Gng7 Gng8 Fgf8 Eif4e Kit Pik3c2a Kitlg Gh Ins2 Irs4 Fgfr3 Irs3 Fgfr1 Fgfr2 Prlr Lama1 Ppp2cb Lama2 Lama3 Fgf15 Met Lamb3 Epas1 Itgb1 Slc2a4 Nras Col11a2 Osm Gng10 Col2a1 Gngt2 Ngfr Ins1 Col4a1 Foxo1 Nos1 Elavl1 Ifnar1 Chrm1 Chrm2 Srebf1 Rps6kb1 Pik3cb Pik3cd Casp9 Pik3c2b Vwf Atf2 Pik3r2 Pdgfrb Ppargc1a Pdgfb Cdc37 MACROPHAGE MARKERS%WIKIPATHWAYS_20260211%WP2271%MUS MUSCULUS Macrophage markers Rac2 Cd74 Cd86 Cd52 Lyz2 Cd14 Cd163 Cd83 Cd68 F3 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260211%WP1250%MUS MUSCULUS Arachidonate epoxygenase epoxide hydrolase Cox5a Cox8a Ephx2 LIPIDS MEASURED IN LIVER METASTASIS FROM BREAST CANCER%WIKIPATHWAYS_20260211%WP4627%MUS MUSCULUS Lipids measured in liver metastasis from breast cancer Lrat FATTY ACID BETA OXIDATION STREAMLINED %WIKIPATHWAYS_20260211%WP3588%MUS MUSCULUS Fatty acid beta oxidation streamlined Cpt2 Acads Acadvl Fabp1 Cpt1a Acsl1 Acsl3 Acsl4 Slc25a20 Hadh Hadhb Decr1 Acat1 Echs1 Acsl5 Acsl6 Cpt1b Slc27a1 Fabp2 Fabp3 Fabp4 Fabp7 Slc27a5 Slc27a4 Slc27a3 Cd36 Slc27a2 Slc27a6 Hadha Acadl Eci1 Acadm PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260211%WP374%MUS MUSCULUS Prostaglandin synthesis and regulation Ptgs2 Ptgfr Ptgir Pla2g4a Anxa6 Prl Cyp11a1 Ednra Edn1 Ednrb Anxa8 S100a6 Scgb1a1 Hsd11b1 Hsd11b2 Anxa5 Anxa4 Tbxas1 Anxa3 Anxa2 Anxa1 S100a10 Ptger4 Hpgd Ptger2 Ptgds Ptger3 Ptgis Ptger1 Ptgs1 Ptgdr PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260211%WP63%MUS MUSCULUS Pentose phosphate pathway Rpia Rpe Taldo1 Pgls Tkt G6pdx Pgd STATIN PATHWAY%WIKIPATHWAYS_20260211%WP1%MUS MUSCULUS Statin pathway Apoa4 Apoc2 Pltp Apoe Cyp7a1 Lrp1 Dgat1 Lpl Apoc1 Lipc Soat1 Mttp Hmgcr Lcat Abca1 Ldlr Scarb1 Apoc3 Apoa1 NOVEL JUN DMP1 PATHWAY%WIKIPATHWAYS_20260211%WP3654%MUS MUSCULUS Novel Jun Dmp1 pathway Araf Arf1 Dmp1 Mapk1 Junb Braf E2f1 Raf1 Fos Kras Map2k2 Jun Ccnd1 Nras Rras Map2k1 Rb1 Mapk3 Trp53 Hras Cdk4 Myc Mdm2 Cdkn2a Ets1 Ets2 TGF BETA RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP258%MUS MUSCULUS TGF beta receptor signaling pathway Nfya Cav1 Fos Jun Ncoa1 Mapk14 Ccnd1 Crebbp Fkbp1a Atf3 Tgif1 Mapk8 Zeb2 Foxh1 Snw1 Skil Eng Lef1 Camk2a Myc Ctcf Sp1 Runx2 Tgfbr3 Kat2b Stk11 Smad2 Zfyve9 Tgfbr1 Eif3i Tgfbr2 Smad6 Smad7 Mef2c Prkar1b Prkcb Ube2d3 Map2k6 Ube2d1 Prkar2a Map2k3 Map3k7 Skp1 Btrc Ube2d2a Dab2 Axin1 Axin2 Tgfb2 Cul1 Ets1 Dvl1 Foxo3 Erbin Junb Pard3 Stambpl1 Kpnb1 Sumo1 Cdc27 Prkcd Cdc23 Dcp1a Hnf4a Rbx1 Pik3r1 Camk2g Eid2 Hgs Trp73 Ar Camk2d Nup153 Camk2b Gipc1 Arrb2 Sdc2 Anapc5 Snip1 Hspa8 Anapc4 Anapc1 Anapc2 Snx4 Trap1 Snx2 Vdr Snx1 Anapc7 Cited1 Tfdp2 Snx6 Cops5 Nup214 Rbl2 Sparc Fnta Esr1 Cdc16 Xpo1 Foxg1 Zeb1 Anapc10 Smurf2 Stk11ip Hoxa9 Nfyb Mef2a Nfyc Strap Fzr1 Ap2b1 Acvrl1 Fosb Ccne1 Cd44 Hdac1 Yap1 Tfdp1 Foxo1 Ccnb2 Ppp2r2a Foxo4 Rbl1 Cdc25a Ep300 Tgfb1 Rb1 Jund Trp53 Rock1 Atf2 Pik3r2 Smad3 Tgfb3 Cdk6 Smad4 Cdk4 Cdk2 Cdk1 Ctnnb1 Pias1 Pias2 Tab1 Daxx E2f4 Cdkn1a E2f5 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260211%WP567%MUS MUSCULUS Eukaryotic transcription initiation Ilk Ccnh Mnat1 Taf13 Taf12 Gtf2f2 Tbp Polr2c Gtf2a2 Polr2a Gtf2b Gtf2e1 Polr2b Taf9 Gtf2e2 Polr2g Polr2k Polr2h Gtf2h2 Gtf2h1 Polr2e Gtf2h4 Gtf2h3 Polr2i Ercc2 Polr2j Ercc3 Cdk7 Taf7 Polr1b Taf6 Polr1c Taf5 Polr3d Polr1a Polr3e Polr3b Polr1d Polr3h Ak6 Polr3k ID SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP512%MUS MUSCULUS ID signaling pathway Ngf Vegfa Kdr Nfkb1 Elk1 Igf1 Id3 Rela Cd40lg Rbl2 Lck Atf3 Hes1 Tgif1 Ccna2 Acvrl1 Ccne1 Elk3 Pax5 Pax8 Id2 Tcf12 Id4 Msc Tcf7l2 Egf Smad1 Smad5 Rbl1 Srebf1 Flt1 Igf1r Myod1 Elk4 Myog Myf6 Myf5 Rb1 Psmd4 Smad3 Bmpr2 Smad4 Bmp2 Cdk2 Ctnnb1 Pax2 Irs1 Id1 Bmp6 Tcf3 Tert OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260211%WP1248%MUS MUSCULUS Oxidative phosphorylation Ndufc1 Ndufc2 mt-Nd1 mt-Nd2 mt-Nd3 Ndufa10 Ndufs1 Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Atp5mc3 Atp5mc2 Ndufa3 Ndufa2 Ndufa5 Atp5pb Ndufa7 Atp5pd Ndufa6 Ndufa9 Ndufa8 Atp5pf Ndufb10 Atp5po Ndufb2 Ndufb6 Ndufb5 mt-Nd4l Ndufb7 Ndufb9 Ndufa11 Coxfa4l2 Atp5mc1 Atp6ap2 Atp6ap1 Gzmb Ndufb8 Coxfa4 ATP6 Atp5f1e Atp5f1d mt-Atp8 Atp5mf Atp5me Ndufv2 Dmac2l Atp5mg Ndufv1 Atp5f1b Ndufv3 Atp5f1a mt-Nd4 mt-Nd5 mt-Nd6 CHEMOKINE SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP2292%MUS MUSCULUS Chemokine signaling pathway Ccr2 Akt1 Pxn Mapk1 Prkx Ccl2 Nfkb1 Braf Cx3cr1 Sos2 Pik3ca Prkaca Gnb3 Sos1 Rela Shc2 Nfkbib Gng14 Ccr1 Chuk Gngt1 Ccr1l1 Akt2 Map2k1 Gnb1 Mapk3 Grb2 Grk5 Hras Shc3 Grk4 Ccl11 Grk6 Ccl4 Ccl3 Gnb2 Gnb4 Akt3 Gnb5 Gng11 Cxcl15 Gng12 Gng13 Stat3 Rac2 Stat1 Ptk2 Vav3 Rap1a Rap1b Prkacb Pik3r5 Vav2 Crk Prkcb Gng3 Bcar1 Gng2 Gng5 Pak1 Gng4 Gng7 Csk Gng8 Nfkbia Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Fgr Hck Plcb1 Crkl Jak3 Foxo3 Jak2 Pard3 Rac1 Itk Prkcd Vav1 Ccr10 Pik3r1 Raf1 Ncf1 Shc1 Arrb2 Arrb1 Pik3cg Kras Prkcz Lyn Xcr1 Ptk2b Nras Gnai2 Gnai1 Gnai3 Gng10 Ccr7 Gngt2 Plcb4 Stat2 Plcb3 Gsk3a Plcb2 Tiam1 Tiam2 Cxcr1 Rasgrp2 Shc4 Ppbp Grk1 Grk2 Elmo1 Stat5b Ccl21a Cxcl16 Gsk3b Cxcl13 Ccl20 Cxcl14 Ccl5 Ccl27a Xcl1 Ccl19 Ccl17 Dock2 Was Ccl9 Ccl8 Ccl12 Cxcl1 Cxcl9 Cxcl2 Ccl7 Ccl6 Ccl1 Pik3cb Pf4 Pik3cd Prex1 Cx3cl1 Cdc42 Ccl28 Ccl26 Ccl24 Ccl25 Ccl22 Wasl Rock2 Cxcr2 Cxcr3 Rock1 Pik3r2 Ikbkb Cxcl10 Ccr9 Cxcr4 Cxcr5 Ikbkg Ccr8 Cxcr6 Ccr6 Rhoa Ccr5 Cxcl5 Ccr4 Ccr3 T CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP480%MUS MUSCULUS T cell receptor signaling pathway Cd2 Dusp3 Akt1 Pxn Def6 Cd4 Mapk1 Trat1 Nfam1 Abi1 Braf Sos2 Wasf2 Grap2 Sh2b3 Khdrbs1 Zap70 Ptpn22 Dbnl Syk Rasa1 Fos Ptprc Cblb Sos1 Jun Prkcq Lck Mapk7 Crebbp Map2k1 Mapk3 Ncl Grb2 Vasp Arhgef7 Nck1 Plcg1 Txk Creb1 Rac2 Stat1 Ptk2 Vav3 Rap1a Stat5a Vav2 Crk Dtx1 Pak1 Muc1 Git2 Rapgef1 Sla2 Cd2ap Dlg1 Grap Shb Bcl10 Lat Crkl Jak3 Itk Gab2 Vav1 Pik3r1 Shc1 Card11 Ptpn6 Lime1 Cbl Lcp2 Ptpn11 Cd5 Fyn Sh3bp2 Lyn Nedd9 Ptk2b Map2k2 Cish Cebpb Hdac7 Rasgrp2 Stat5b Dock2 Sh2d3c Was Arhgdib Cdc42 Ppp3cb Sla Abl1 Prkd2 Sit1 Sh2d2a Lax1 Wipf1 Stk39 Map3k1 Fcrl5 Arhgef6 Unc119 Cabin1 Ripk2 Pag1 Itpr1 Tubb5 Nfatc2 Pik3r2 Fyb1 Homer3 Pstpip1 Cd8a Enah Ptprj Acp1 Ptprh Skap2 Src Ctnnb1 Skap1 Dnm2 Map4k1 Tuba4a Ptpn12 Evl Cd247 Cd3g Cd3e Ptpn3 Cd3d TCA CYCLE%WIKIPATHWAYS_20260211%WP434%MUS MUSCULUS TCA cycle Pdk1 Fh Mdh1 Idh3g Mdh2 Suclg2 Pdk3 Sucla2 Idh3a Pcx Pdhb Idh3b Ogdh Pdp1 Pdp2 Aco2 Dlat Sdhd Sdhc Sdhb Sdha Dld Pdha1 Pdha2 Pdhx Cs Suclg1 Pdk4 Idh2 Pdk2 Dlst IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP151%MUS MUSCULUS IL 5 signaling pathway Crkl Akt1 Mapk9 Foxo3 Mapk1 Jak2 Nfkb1 Rac1 Elk1 Vav1 Prkcd Icam1 Pik3r1 Pla2g4a Syk Raf1 Il2rb Hcls1 Shc1 Ptpn6 Cbl Il5 Ptpn11 Pik3cg Shc2 Kras Pim1 Sox4 Sdcbp Itgb2 Lyn Ptk2b Rap1gap Map2k2 Jun Mapk14 Il5ra Mapk3 Grb2 Jak1 Hras Gsk3a Stat3 Stat1 Stat5b Stat5a Gsk3b Ywhaz Prkcb Nfkbia Rapgef1 Bax Unc119 Ccnd3 Csf2rb Atf2 Pik3r2 Hck Rps6ka1 Alox5ap Btk Alox5 Ctnnb1 Socs1 Dnm2 Sh2b2 Itgam Cdkn1b GPCRS ODORANT%WIKIPATHWAYS_20260211%WP1397%MUS MUSCULUS GPCRs odorant Ptgdr2 Gpr137b Adgrf5 Gpr137c Slc52a2 Gpr161 Adgrf2 Gpr180 Gpr107 Gpr137 Gpr4 Gpr179 Gpr155 Tpra1 Gpr108 Gpr89 Gpr31 Wls Adgrg5 Hcar1 Adgrg6 Adgrg7 Gpr160 Adgrg3 Mrgpra6 Tas2r39 Or5p52 Tas2r38 Gpr61 Gpr63 Mrgpra1 Or10d3 Mrgpra4 Gpr176 Gpr173 Gpr171 Or8g17 Vmn2r1 Cmklr1 Cmklr2 Or4c3d Or8u9 Or5g25 Gpr75 Or5ap2 Adgra2 Gpr183 Tas1r2 Or5g9 Or10n1 Or10d1b Gpr101 Tas1r3 Or5p76 Or10h28 Gpr87 Or5p4 Gpr85 Tas2r135 Tas2r134 Gpr82 Or7d11 Tas2r136 Or5ar1 Or5b21 Gpr19 Or5p58 Or5p57 Or2c1 Mrgprb8 Gpr12 Mrgprb1 Tas2r143 Mrgprb2 Adgra3 Mrgprb3 Mrgprb4 Mrgprb5 Tas2r117 Tas2r116 Opn1sw Rho Or8a1b Gpr26 Gpr165 Or5h19 Gpr25 Gpr162 Or5h17 Or5h18 Gpr27 Gpr22 Gpr21 Or5j3 Ackr5 Gpr20 Tas2r113 Or3a10 Tas2r114 Tas2r129 Adgrd1 Gpr139 Oprl1 Gpr135 Or5p79 ADGRF3 Gpr33 Taar6 Gpr35 Taar9 Or7e178 Taar3 Tas2r120 Or5p80 Taar2 Taar5 Taar4 Or5g26 Tas2r124 Tas2r125 Gpr142 Gpr141 Opn1mw Mrgprx1 Taar7e Or5t7 Or5t9 Gpr153 Tas2r106 Tas2r107 Gpr152 Gpr150 Or2a7 Adgrf1 Tas2r109 Tas1r1 Or8b8 Or5t17 Or5t15 Gpr3 Or9s13 Or8b3 Or10p22 Gpr157 Gpr158 Gpr88 Gpr156 Gpr84 Or5m5 Gpr83 Lgr4 Lgr5 Lgr6 Tas2r102 Or4b13 Mrgpre Tas2r104 Mrgprf Mrgprg Or6b9 Or2b6 Or1j1 Or7a40 Or2y1b Gpr34 V1ra8 Gpr37 Vmn1r53 Vmn1r54 Vmn1r51 Vmn1r52 Gpr146 Or1e16 Adgrf4 Vmn1r48 Vmn1r46 Vmn1r47 Gpr37l1 Vmn1r45 Vmn1r42 Vmn1r43 Mrgprh Or1m1 Brs3 TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260211%WP1253%MUS MUSCULUS Type II interferon signaling IFNG Ifnb1 Jak2 Tap1 Stat1 Eif2ak2 Prkcd Irf4 Icam1 Nos2 Ptpn11 Cxcl9 Ifng Hist2h4 Gbp2b Ifngr2 Ifngr1 Reg1 Ciita Irf1 Irf2 Irf8 Isg15 Psmb9 Irf9 Ifit2 Il1b Spi1 Jak1 Stat2 Cxcl10 Socs1 Cybb Socs3 TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP246%MUS MUSCULUS TNF alpha NF kB signaling pathway Traf2 Akt1 Fbl Nfkb1 Cav1 Pebp1 Ywhah Prkaca Tnfrsf1b Tnfrsf1a Rela Papola Nfkbib Elp1 Casp2 Rel Chuk Crebbp Map3k14 Akt2 Ikbke Polr1b Polr1c Polr1a Polr1d Polr1e Ddx3x Hsp90ab1 Gab1 Capn3 Ywhae Ywhab Stat1 Ptk2 Psmd12 Psmd13 Ywhaz Psmb5 Birc3 Birc2 Map2k5 Psmc2 Psmc1 Nfkbia Psmc3 Relb Traf3 Bag4 Psmd7 Skp1 Ppp2ca Traf1 Psmd6 Nfkbie Nfkb2 Alpl Psmd3 Btrc Gtf2i Cul1 Csnk2a2 Csnk2a1 Hsp90aa1 Mark2 Csnk2b Nr2c2 Rack1 Sumo1 Ptpn11 Akap8 Rps11 Rps13 Prkcz Tab2 Polr2h Rnf25 Nkiras1 Rpl4 Nkiras2 Nlrp4e Rpl6 Tbk1 Unc5cl Dpf2 Azi2 Ppp1r13l Rnf216 Usp2 Polr1g Mcm7 Fbxw11 Casp8ap2 Txlna Tank Ywhag Tradd Actl6a Smarce1 Hdac2 Rps6ka5 Tifa Cdc34 Traip Rpl30 Nfkbiz Hdac1 Glg1 Ripk3 Cradd G3bp2 Dcaf7 Hdac6 Cops3 Kpna6 Mcc Kpna3 Kpna2 Dap Tnfrsf11a Bcl3 Tab3 Ccar2 Traf4 Rpl8 Map3k3 Pfdn2 Gsk3b Traf5 Fadd Faf1 Tnfrsf8 Smarcb1 Rasal2 Mcm5 Peg3 Bcl7a Cyld Fkbp5 Smarca4 Tnip2 Rps6kb1 Pdcd2 Nsmaf Zfand5 Ripk1 Cflar Map3k2 Commd1 Iqgap2 Trpc4ap Fancd2 Casp8 Psmd1 Casp7 Pml Ktn1 Usp11 Smarcc2 Casp3 Smarcc1 Tnfaip3 Map3k8 Lrpprc Mtif2 Map3k1 Eif4a3 Pkn1 Ripk2 Pias3 Ikbkb Ube2i Hspb1 Tnip1 Src Traf6 Ikbkg Flna Tab1 Tnf Cdc37 Kcnq1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260211%WP273%MUS MUSCULUS Ovarian infertility Gja4 Lhcgr Prlr Tbp Cyp19a1 Vdr Esr2 Smpd1 Ncor1 Zp3 Inha Zp2 Pgr Syne2 Ccnd2 Bmpr1b Mlh1 Nr5a1 Gdf9 Dmc1 Msh5 Nrip1 Smad3 Cdk4 Fshr Egr1 Ptger2 Cebpb Atm Dazl Cdkn1b ESC PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260211%WP339%MUS MUSCULUS ESC pluripotency pathways Akt1 Mapk1 Braf Elk1 Fos Sos1 Fgfr4 Il6st Fgf16 Fgf17 Fgf14 Jun Fgf12 Fgf13 Fgf11 Mapk7 Fgf20 Mapk6 Fgf21 Mapk4 Fgf22 Fgf7 Akt2 Map2k1 Pten Grb2 Jak1 Hras Nog Fgf2 Fgf6 Fgf4 Fgf3 Fgf9 Mtor Myc Akt3 Wnt1 Lif Egf Smad1 Gab1 Fgf10 Stat3 Araf Smad9 Pdgfra Pdgfa Egfr Smad5 Smad6 Smad7 Map2k6 Map2k5 Mapk12 Map2k3 Wnt11 Wnt5a Wnt6 Wnt7b Fgf8 Wnt5b Fgf18 Wnt9b Wnt10a Wnt2b Wnt16 Wnt2 Wnt4 Axin1 Wnt3 Fzd4 Fzd6 Fzd8 Actr2 Bmpr1a Wnt3a Dvl1 Dvl2 Dvl3 Fzd3 Fgfr3 Lifr Fgfr1 Lrp6 Fgfr2 Lrp5 Raf1 Fgf15 Wnt7a Ptpn11 Apc Fzd1 Fzd2 Fzd5 Fzd7 Map2k2 Fzd9 Fgf23 Acvr1 Wnt10b Hnf1a Selenop Gsk3b Fgf1 Pik3cd Bmpr1b Pik3r2 Fgf5 Eras Smad4 Bmpr2 Pdgfrb Ctnnb1 Pdgfb Mdm2 Bmp4 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP88%MUS MUSCULUS Toll like receptor signaling Ticam2 Irak4 Ralbp1 Nfkb1 Abi1 Eif2ak2 Ticam1 Nr2c2 Fadd Irak2 Irak1 Tlr2 Map2k6 Myd88 Irak3 Irf3 Tab2 Chuk Casp8 Tlr4 Tirap Mapk14 Tlr3 Traf3 Casp3 Ikbke Nfkb2 Tbk1 Mal Mxd3 Ikbkb Traf6 Ikbkg HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260211%WP3673%MUS MUSCULUS Hfe effect on hepcidin production Tmprss6 Hjv Hfe Hamp Smad7 Id1 Bmp6 DISTAL CONVOLUTED TUBULE 1 DCT1 CELL%WIKIPATHWAYS_20260211%WP4183%MUS MUSCULUS Distal convoluted tubule 1 DCT1 cell Wnk1 Cab39 Stk39 Slc12a3 Wnk4 Kcnj16 Clcnkb CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260211%WP222%MUS MUSCULUS Cytokines and inflammatory response Ifnb1 Cd4 Pdgfa Cxcl3 Ifna1 Il2 Il4 Il5 Cxcl1 Ifng Il1a Tgfb1 Il13 Il1b Il3 Csf2 Csf3 Csf1 Il10 Il12b Il11 H2-Eb1 Il15 Tnf Il12a Il6 Il7 DRAVET SYNDROME SCN1A A1783V POINT MUTATION MODEL%WIKIPATHWAYS_20260211%WP5298%MUS MUSCULUS Dravet syndrome Scn1a A1783V point mutation model Rictor Scn1a Scn1b Akt1 Gabra4 Grm3 Kdr Ppp1r1b Nfkb1 Gabra3 Stxbp3 Gabra2 Pcdh19 Slc6a1 Slc16a7 Pik3ca Slc16a1 Slc12a5 Stx8 Kcna2 Gria4 Gria3 Gls Scn2b Gria1 Chd2 Maob Stx16 Ldhb Ctps2 Cacna2d3 Kcnj9 Scn3a Scn3b Slc1a3 Slc38a3 Slc17a7 Fgf13 Kcnj3 Cacnb4 Scn4b Mapkap1 Kcnj10 Gabrb1 Epb41l3 Gabrb3 Prr5l Gabbr2 Gabbr1 Slc1a2 Slc2a1 Rasgrf1 Mtor Camk2a Ldha Cacna1a Cacna1b Grin1 Gad1 Mapk11 Slc2a3 Grin2a Gabra1 Mlst8 Stxbp1 Glul Cacnb3 Cacnb1 Gad2 Maoa Gfap Tnf Prr5 NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP29%MUS MUSCULUS Notch signaling pathway Dvl3 Ctbp1 Mfng Rbpj Numb Psen1 Psen2 Maml3 Numbl Ncstn Aph1a Aph1b Ctbp2 Dtx1 Maml1 Ncor2 Jag2 Jag1 Notch4 Cirsr Notch1 Notch2 Notch3 Lfng Crebbp Dll1 Dll3 Dtx2 Dll4 Dtx3 Dtx4 Hes1 Dtx3l Hes5 Kat2a Rfng Ptcra Snw1 Hdac2 Adam17 Hdac1 Tnf Kat2b Rbpjl Dvl1 Dvl2 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4351%MUS MUSCULUS Omega 9 fatty acid synthesis Acsl1 Acsl3 Acsl4 Fads2 Fads1 Acot1 Elovl2 Acot2 Elovl3 Elovl5 Fasn Elovl1 Scd2 Elovl6 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260211%WP33%MUS MUSCULUS Fatty acid omega oxidation Adh7 Cyp1a2 Adh4 Adh1 Cyp2e1 Aldh2 Cyp1a1 Aldh1a1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP300%MUS MUSCULUS Histone modifications Hdac2 Ehmt2 Ehmt1 Hdac1 Hat1 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260211%WP578%MUS MUSCULUS Leptin insulin signaling overlap Stat3 Pdpk1 Akt1 Irs4 Jak2 Socs2 Irs3 Lep Insr Lepr Dgkz Pik3cg Socs1 Ins1 Socs3 Irs1 Irs2 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260211%WP412%MUS MUSCULUS Oxidative stress response Junb Nfkb1 Cyp1a1 Gpx1 Gstt2 Gpx3 Fos Gsr Txnrd1 Txnrd2 Cat Mapk14 Ugt1a1 Mapk10 Mt1 Maoa Txn2 Nqo1 Nfix Hmox1 Sod3 Sod2 Gclc Sod1 Cyba Gabpb1 Sp1 Mgst1 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260211%WP157%MUS MUSCULUS Glycolysis and gluconeogenesis Pkm Pklr Pdhb Dlat Ldhb Gck Slc2a4 Pdhx Slc2a1 Gpi Eno3 Eno2 Mpc1 Mpc2 Pgam2 Ldha Pgam1 Slc2a5 Gapdh Ldhc Fbp1 Fbp2 Ldhal6b Gapdhs Aldoc Aldoa Pfkl EG433182 Pgk1 Pgk2 Pfkm Slc2a2 Pfkp Slc2a3 Pck1 G6pc1 Hk2 Hk1 Mdh1 Hk3 Mdh2 Aldob Pcx Tpi1 Dld Pdha1 Pdha2 Got1 Got2 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260211%WP431%MUS MUSCULUS Nuclear receptors in lipid metabolism and toxicity Cyp24a1 Cyp26a1 Nr1i3 Nr1i2 Abcb1a Abcd2 Abcd3 Abcb4 Cyp2b10 Cyp7a1 Rara Nr1h4 Rarb Abcg1 Abcc3 Rarg Abcg5 Abcb11 Vdr Cyp27b1 Nr1h3 Cyp4b1 Ppard Cyp8b1 Abcc2 Ppara Pparg Cyp1a2 Cyp2e1 Abca1 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260211%WP3625%MUS MUSCULUS Tyrobp causal network in microglia Cd4 Sh2b3 Ncf2 Hcls1 Tnfrsf1b Rgs1 Itgb2 C3 C1qc Slc1a5 Gal3st4 Spp1 Runx3 Creb3l2 Itgax Tgfbr1 Stat5a Cxcl16 Gpx1 Plek Rbm47 Adap2 Il18 Sft2d2 Cytl1 Tmem106a Lyl1 Dpyd Il13ra1 Cd84 Kcne3 Abcc4 Bin2 Npc2 Elf4 Lhfpl2 Cd37 Samsn1 Ppp1r18 Il10ra Zfp36l2 Apbb1ip Fkbp15 Hlx Rnase6 Tcirg1 Loxl3 Gapt Slc7a7 Rps6ka1 Pycard Capg Igsf6 Nrros Maf Tyrobp Nckap1l Itgam PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260211%WP4835%MUS MUSCULUS Peroxiredoxin 2 induced ovarian failure Casp3 Prdx2 Star Cycs Cyp11a1 Hsd3b3 Bax NA K ATPASE SRC SIGNALING%WIKIPATHWAYS_20260211%WP5051%MUS MUSCULUS Na K ATPase Src signaling Crkl Akt1 Mapk9 Mapk1 Kdr Ilk Rac1 Braf Cav1 Elk1 Vav1 Pik3r1 Pik3ca Raf1 Rac3 Shc1 Met Sos1 Pik3cg Fyn Map2k2 Jun Ccnd1 Mapk7 Pak6 Mapk6 Mapk4 Akt2 Map2k1 Pten Bcl2 Grb2 Hras Mapk8 Shc3 Erbb2 Mtor Akt3 Pak4 Bad Cav3 Cav2 Blk Srms Txk Araf Rac2 Pdgfra Ptk2 Selenop Egfr Tesk2 Rap1a Tnk1 Rap1b Apaf1 Gsk3b Ptk6 Pik3r5 Crk Flt1 Birc3 Igf1r Birc2 Pik3r4 Dock1 Map2k6 Bcar1 Pak5 Map2k5 Pak1 Pak3 Pik3cb Styk1 Pak2 Pik3cd Mapk12 Map2k3 Rapgef1 Atp1b1 Tnk2 Casp9 Casp3 Cycs Cyct Ccnd2 Ccnd3 Pik3r2 Fgr Hck Pdgfrb Xiap Src Ctnnb1 Atp1a1 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260211%WP1272%MUS MUSCULUS Selenium micronutrient network mt-Co1 Selenop Xdh Fads2 Gpx2 Gpx1 Fads1 Gpx4 Gpx3 Gpx6 Tbxas1 Gsr Mtr Kmo Alox5 Cat mt-Co2 Ptges Pnpo Ptgds Mthfr Ptgis Selenok NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP1256%MUS MUSCULUS Nod like receptor NLR signaling pathway Ikbkb Erbin Rela Ephb2 Ikbkg Chuk Cd40 Mapk8 Map3k7 PPAR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP2316%MUS MUSCULUS PPAR signaling pathway Cpt2 Acaa1b Cyp4a12a Apoa2 Pltp Apoa5 Cyp4a12b Cyp4a14 Cpt1a Acsl1 Fabp5 Ilk Scp2 Cyp4a10 Fabp6 Acsl3 Acsbg1 Acsl4 Acsbg2 Acox1 Mmp1a Mmp1b Acox2 Me1 Acox3 Cpt1c Acaa1a Cyp7a1 Pck2 Plin1 Ucp1 Adipoq Nr1h3 Ppard Ppara Pparg Fabp4 Rxrb Rxra Sorbs1 Rxrg Pdpk1 Fabp1 Pck1 Fads2 Gk Lpl Hmgcs2 Gk2 Acsl5 Acsl6 Cpt1b Slc27a1 Cyp8b1 Ubc Fabp2 Fabp3 Fabp7 Slc27a5 Slc27a4 Cyp27a1 Cd36 Slc27a2 Slc27a6 Scd4 Scd3 Scd2 Scd1 Aqp7 Dbi Angptl4 Cyp4a30b Cyp4a32 Acadl Olr1 Cyp4a31 Ehhadh Apoc3 Cyp4a29 Apoa1 Acadm MISMATCH REPAIR%WIKIPATHWAYS_20260211%WP1257%MUS MUSCULUS Mismatch repair Rpa1 Pcna Pold1 Mlh1 Msh6 Lig1 Msh2 Rfc1 Exo1 FAS PATHWAY AND STRESS INDUCTION OF HSP REGULATION%WIKIPATHWAYS_20260211%WP571%MUS MUSCULUS FAS pathway and stress induction of HSP regulation Apaf1 Fadd Faf1 Lmna Parp1 Lmnb1 Arhgdib Ptpn13 Lmnb2 Mapkapk3 Sptan1 Pak1 Dffa Casp6 Dffb Cflar Il1a Pak2 Mapkapk2 Prkdc Casp8 Map2k4 Casp7 Jun Map3k7 Casp9 Casp3 Fas Rb1 Map3k1 Bcl2 Ripk2 Mapk8 Fasl Hspb1 Tnf Daxx GPCRS NON ODORANT %WIKIPATHWAYS_20260211%WP1396%MUS MUSCULUS GPCRs non odorant Vipr2 Ghrhr Adcyap1r1 Gipr Adgrg2 Gcgr Adgre1 Adgrl2 Sctr Adgrl3 Adgrl4 Adgrl1 Adora2b Glp2r Adora2a Calcrl Lpar6 Glp1r Crhr2 P2ry6 P2ry4 P2ry2 P2ry1 Lpar4 Gabbr2 Cysltr2 Pth1r Fzd4 Fzd6 Fzd8 Adra2a Adra2c Adra2b Htr4 Hrh1 Htr6 Htr7 Hrh2 Htr2b Drd3 Drd4 Htr1f Htr1b Htr5b Htr5a F2r Cckar Ednrb Cxcr2 Npy1r Cxcr3 Gnrhr Npy5r Ntsr2 Ntsr1 Trhr Mc2r Oprd1 Fshr C3ar1 Ccr9 Cxcr4 Cxcr5 Ccr8 Cxcr6 Ccr6 Tbxa2r Ccr4 Ptgdr Ccr3 Ccr2 Galr2 Ptgfr Cckbr Galr1 Grm3 Npy4r Cx3cr1 Lhcgr Avpr2 Sstr4 Sstr3 Sstr2 Ptgir Mc1r Sstr1 Avpr1b Mc5r Tacr1 Avpr1a Tacr2 C5ar1 Fpr1 Lpar5 Nmbr Bdkrb2 Bdkrb1 Tshr Agtr1a Agtr1b Ccr1 Oxtr Npy2r Npy6r Grpr Mc3r Gper1 Ccr1l1 Rxfp2 Rxfp1 Lpar1 Lpar3 Lpar2 Oprk1 Htr2a Htr2c Crhr1 Ghsr Prokr1 Adgrg1 Ackr3 Ednra Rrh Adrb2 Adrb1 Sstr5 Smo Oprm1 Tacr3 Calcr Casr Fzd3 Ccr10 Vipr1 Drd1 Celsr3 Drd2 Celsr1 Drd5 Celsr2 Gpr174 Fzd1 Rxfp3 Xcr1 Rxfp4 Fzd2 Tas2r16 Fzd5 Tas2r13 Fzd7 Tas2r137 Adgrb1 Fzd9 Adgrb2 Adgrb3 Gpr18 Gpr15 Gpr17 Adora1 Tas2r140 Adora3 Npbwr1 Ltb4r2 Gpbar1 Nmur2 Nmur1 Tmigd3 Tas2r4 Grm1 Tas2r7 Gabbr1 Mchr1 Rgr Ccr7 Taar1 Gprc5b Gprc5a Gpr132 Kiss1r Gprc5d Npffr2 Gprc6a Gpr6 Mtnr1b Npsr1 Mtnr1a P2ry10 P2ry13 Cnr2 Ptger4 P2ry12 Ptger2 P2ry14 Ptafr Mas1 Ptger3 Gpr50 Htr1d Ptger1 F2rl1 Tas2r40 S1pr3 Tas2r41 Ltb4r1 Htr1a S1pr4 F2rl2 F2rl3 Prokr2 Cxcr1 Gpr143 Hcar2 Gpr65 Adra1b Adgre5 Adra1a C5ar2 Adrb3 Ffar3 Gpr68 Adra1d Ffar4 Aplnr Ffar1 Ffar2 Chrm1 Chrm3 Hrh4 Chrm2 Hrh3 Opn4 Chrm5 Opn3 Mc4r Chrm4 Ccrl2 Oxgr1 Opn5 Sucnr1 Gpr119 S1pr1 Pth2r Tas2r119 Prlhr S1pr2 Grm2 S1pr5 Grm5 Grm4 Grm7 Grm6 Grm8 Tas2r110 Qrfpr Tas2r123 Adgre4 Hcrtr2 Hcrtr1 Cysltr1 Tas2r105 Ackr2 Uts2r Mrgprd Ackr1 Tas2r103 Cnr1 Agtr2 FATTY ACID OXIDATION%WIKIPATHWAYS_20260211%WP2318%MUS MUSCULUS Fatty acid oxidation Cpt2 Acads Acadvl Cpt1a Slc25a29 Echs1 Hadh Acaa2 Mttp Acadm MECHANISMS ASSOCIATED WITH PLURIPOTENCY%WIKIPATHWAYS_20260211%WP1763%MUS MUSCULUS Mechanisms associated with pluripotency Ddb1 Rbbp7 Ptprs Hells Suz12 Pbrm1 Xpo4 Sall1 Med12 Zfx Mtf2 Acvr1c Lyar H3-3b Stk40 Pou2f1 Rybp Leo1 Mbd3 Dpysl2 Cdx2 Acvr1b Mbd2 Satb2 Satb1 Elp4 Etv5 Wwp2 Il6st Zscan10 Pim1 Grsf1 Nr2c1 Rif1 Zfp42 Mpl Pou5f1 Ipo7 Nanog Mycn Ncoa1 Ipo9 Dgka Pim3 Tle4 Tle2 Fbxo15 Kdm1a Usp7 Hira Perp Pten Sall4 Sall3 Mapk3 Tcf7 Jarid2 Nppb Tfap2c Jak1 Niban1 Nedd4l Tfe3 Tfcp2l1 Jade1 Plet1 Zfp57 Nacc1 Kmt2d Sox2 P4ha1 Ogt Cdc73 Lef1 Spp1 Otx2 Kdm4c Zic2 Zic3 Gadd45gip1 Cdk2ap1 Lif Utf1 Smad1 Ewsr1 Eed Smad2 Mybl2 Npr1 Kdm5c Stat3 Kdm6a Rcn2 Chd4 Igfbp3 Smarca2 Smarca5 Dppa4 Tgfbr1 Trim28 Trim24 Epop Smad7 Rnf2 Zfp219 Mta1 Smarcad1 Arid3b Ercc5 Trim33 Kdm3a Tbx3 Ssrp1 Dkk1 Yy1 Wnt5a Relb Shh Hand2 Nme2 Irs1 Pin1 Ctbp1 Sumo1 Icam1 Lrp5 Nkd1 Raf1 Esrrb Nr2f6 Ptpn11 Apc Nr0b1 Nr2f2 Nr2f1 Dnmt3a Socs2 Nr5a2 Cers2 Cd44 Dnmt3b Dnmt1 Hdac2 Hdac4 Cdh1 Hdac1 Cdkn2a Kpna2 Ppp2r1a Sgk1 Gsk3b Myod1 Smarca4 Ep300 Gadd45a Tgfb1 Pml Smarcc1 Hif1a Gdf9 Trp53 Fgf5 Eras Smad3 Smad4 Bmpr2 Gata6 Cdk2 Mdm2 Atrx Cdkn1a Dazl Tert Rbbp4 Akt1 Mapk1 Nfkb1 Tcl1 Prkaca Fos Insr Inhbb Sos1 Rela Rel Ccnd1 Prkcg Crebbp Map2k1 Grb2 Ncl Sin3a Hras Fgf4 Cad Mtor Rest Myc Ctcf Sp1 Sp3 Gab1 Creb1 Tet1 Tpo Mef2c Ezh2 Mitf Twist1 Hck Foxd3 Axin1 Smo Tfap2a Wnt3a Id1 Dvl1 Rbpj Kpnb1 Fgfr1 Lifr Parp1 Ctbp2 Dffa Fzd1 Itgb1 Notch1 Rbl2 Mef2d Rras Gbx2 Dhx9 Hnrnpu Acvr1 Nodal T Ins1 T2 Tcf7l1 Klf4 Klf2 Klf5 Psen1 Rtn4r Tfeb Pik3cd Casp3 Ehmt2 Znf281 Ehmt1 Rcor2 Rock2 Thap11 Cer1 Cabin1 Sf1 Rock1 Skic8 Atf2 Uhrf1 Nobox Hcfc1 Zmym2 Znf143 Pias4 Kdm6b Kat5 Lefty1 Bcam Ube2i Ocln Dnmt3l Phc1 Ctnnb1 Ctr9 Pias2 Paf1 Tle5 Gatad2a Brca1 Mta2 Gatad2b Cubn Ezh1 Bmp4 Terf2 Ep400 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260211%WP189%MUS MUSCULUS GPCRs class A rhodopsin like Avp Adora2b Adora2a P2ry6 P2ry4 P2ry2 P2ry1 Gpr63 Or8g17 Cmklr1 Or10n1 Gpr87 Gpr19 Or5p57 Or2c1 Gpr12 Or13j1 Or8b12c Or10d1 Or8b12i Or8c15 Opn1sw Or8c16 Or8a1b Or2d3b Or8d2b Or8d1b Tcp10b Or11h4 Fpr2 Gpr27 Or8b12 Or8b40 Or8b39 Or8b101 Or6e1 Or10j5 Gpr45 Or2ag2 Or2ag1 Or8g23 Or8g24 Or8g26 Or8g27 Gpr33 Or8c8 Or8g28 Gpr35 Or8g18 Or10d4b Or10d4c Or10d1c Or8g2b Or2ag19 Or8g32 Or8g34 Or8g35 Or8g36 Or8g37 Or6b6 Opn1mw Or2ag20 Or13c7d Or13c7 Or13c7b Or8g30 Or2d2 Or2d4 Or2d3 Or8g53 Or8g55 Or13e8 Or8d23 Or8a1 Or8b8 Fpr-rs4 Fpr-rs3 Gpr3 Or8b4 Or2d36 Or10a4 Or10a5 Or10a2 Adra2a Adra2c Adra2b Htr4 Hrh1 Htr6 Htr7 Hrh2 Htr2b Drd3 Drd4 Htr1f Htr1b Htr5b Htr5a Gpr37 F2r Cckar Ednrb Cxcr2 Npy1r Cxcr3 Npy5r Ntsr2 Ntsr1 Trhr Brs3 Fpr-s1 Mc2r Oprd1 Fshr C3ar1 Ccr9 Cxcr4 Cxcr5 Ccr8 Ccr6 Ccr5 Tbxa2r Ccr4 Ptgdr Ccr3 Ccr2 Galr2 Galr3 Ptgfr Cckbr Galr1 Ptgdr2 Npy4r Cx3cr1 Lhcgr Avpr2 Sstr4 Sstr3 Sstr2 Ptgir Mc1r Sstr1 Avpr1b Mc5r Avpr1a C5ar1 Fpr1 Nmbr Bdkrb2 Bdkrb1 Tshr Agtr1a Agtr1b Ccr1 Oxtr Npy2r Npy6r Grpr Mc3r Gper1 Ccr1l1 Oxt Oprk1 Htr2a Htr2c Rho Or8g20 Ackr3 Rrh Oprl1 Adrb2 Adrb1 Or8g19 Sstr5 Oprm1 Or6a2 Gpr83 Or6b9 Adora3 Nmur1 Tmigd3 Gabbr1 Rgr Or7a40 Or2ag2b Mtnr1a P2ry13 Cnr2 Ptger4 P2ry12 Ptger2 P2ry14 Ptafr Mas1 Ptger3 Gpr50 Htr1d Ptger1 F2rl1 Gpr34 Ltb4r1 Htr1a F2rl2 F2rl3 Hcar2 Gpr65 Adra1b Adra1a Adrb3 Adra1d Aplnr Chrm1 Chrm3 Chrm2 Opn4 Opn3 Mc4r Chrm4 Ccrl2 Sucnr1 Trhr2 Gpr37l1 Cysltr1 Ackr2 Cnr1 Agtr2 MIRNAS AND TFS IN IPS CELL GENERATION%WIKIPATHWAYS_20260211%WP2375%MUS MUSCULUS miRNAs and TFs in iPS Cell Generation Phf5a Sox2 Ddx39b Sf3a3 Snrpa Pou5f1 Prpf4 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260211%WP1252%MUS MUSCULUS Amino acid conjugation of benzoic acid Acss2 Glyat RETINOL METABOLISM%WIKIPATHWAYS_20260211%WP1259%MUS MUSCULUS Retinol metabolism Adh4 Adh1 Aldh1a2 Cyp26a1 Dhrs3 Rdh8 Rdh12 Rara Aldh1a3 Rarb Rdh10 Bco2 Rarg Abcg5 Bco1 Lpl Npc1l1 Rbp7 Abcg8 Rpe65 Rbp4 Rbp2 Retsat Rbp1 Rdh5 Crabp1 Lrat Crabp2 Rlbp1 Sult1a1 Rxrb Rxra Cd36 Rxrg Cyp2e1 Aldh1a1 Sult2b1 Cyp26b1 Scarb1 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260211%WP327%MUS MUSCULUS GPCRs class C metabotropic glutamate pheromone Gprc5c Grm3 Gabbr2 Grm1 Gabbr1 Gprc5b Gprc5a Gprc5d Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 Casr CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260211%WP4346%MUS MUSCULUS Cholesterol metabolism with Bloch and Kandutsch Russell pathways Acsl1 Acsl3 Acsl4 Cyp7a1 Dhcr24 Nr1h3 Nr1h2 Cyp51a1 Ch25h Ggps1 Lbr Acat2 Soat2 Tm7sf2 Mylip Idi2 Ebp Acot1 Acot2 Fads2 Srebf1 Abcg1 Hmgcs2 Fdps Acat1 Nsdhl Mvk Dhcr7 Srebf2 Fdft1 Hmgcr Lss Sqle Pmvk Sc5d Mvd Msmo1 Cyp27a1 Hmgcs1 Hsd17b7 Cyp46a1 Fads1 Elovl2 Elovl3 Elovl4 Elovl5 Fasn Scd2 Scd1 Idi1 Soat1 Abca1 APOPTOSIS%WIKIPATHWAYS_20260211%WP1254%MUS MUSCULUS Apoptosis Traf2 Hells Akt1 Nfkb1 Igf1 Pik3r1 Trp73 Tnfrsf1b Tnfrsf1a Rela Irf3 Nfkbib Dffa Casp6 Dffb Casp2 Chuk Map2k4 Jun Irf2 Casp1 Bcl2 Hrk Prf1 Trp63 Bok Birc5 Bcl2l2 Tnfsf10 Bnip3l Scaf11 Tradd Pmaip1 Bcl2l1 Lta Irf7 Irf5 Myc Gzmc Tnfrsf21 Casp4 Tnfrsf25 Bad Diablo Cradd Apaf1 Irf4 Fadd Birc3 Igf1r Birc2 Cflar Ripk1 Bcl2l11 Bid Mcl1 Casp8 Nfkbia Irf1 Casp7 Bax Casp9 Traf3 Casp3 Bak1 Traf1 Nfkbie Fas Map3k1 Trp53 Mapk10 Tnfrsf10b Ikbkb Fasl Xiap Mdm2 Ikbkg Irf6 Igf2 Tnf CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260211%WP163%MUS MUSCULUS Cytoplasmic ribosomal proteins Rpsa Rps6ka3 Rpl19 Rpl11 Rpl12 Rps14 Rps11 Rps13 Rpl4 Rps7 Rpl6 Rps6 Rps6kb2 Rpl30 Rps15 Rps16 Rpl3 Rps17 Rps18 Rps15a Rps19 Rpl35 Rps27 Rpl36 Rps28 Rps27a Rps10 Rps29 Rpl37 Rps12 Rps6ka2 Rps20 Rpl38 Rpl31 Rpl8 Rpl34 Rpl39 Rpl36a Rpl9 Rps3a1 Rps23 Rpl7 Rps8 Rps5 Rpl32 Rpl37a Rps24 Rplp2 Rpl24 Rpl27 Rpl28 Rpl29 Rpl21 Rpl26 Rplp0 Rplp1 Rpl13a Rpl18a Rpl22 Rpl13 Rps4x Rpl15 Rpl17 Rpl18 Rpl10 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps26 Rpl27a Rps21 Rpl41 Rpl35a Fau Rpl23a Rps6ka1 MAPK CASCADE%WIKIPATHWAYS_20260211%WP251%MUS MUSCULUS Mapk cascade Araf Mapk1 Braf Elk1 Map3k3 Raf1 Map2k6 Kras Map3k2 Mapk12 Map2k4 Map2k3 Map2k2 Jun Mapk14 Nras Map3k12 Rras Map2k1 Map3k1 Mapk3 Rasa3 Map2 Sipa1 Hras Mapk10 Plcb3 Mbp MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260211%WP1263%MUS MUSCULUS Mitochondrial gene expression Gabpa Nrf1 Tfb1m Ppp3ca Tfb2m Esrra Mterf1a Hcfc1 Gabpb2 Mterf3 Tfam Pprc1 Polrmt Ppargc1a Ppargc1b Camk4 Myef2 Sp1 Creb1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260211%WP523%MUS MUSCULUS Regulation of actin cytoskeleton Baiap2 Diaph3 Pxn Apc2 Rassf7 Mapk1 Fgd1 Tmsb4x Braf Sos2 Arhgap35 Wasf2 Gsn Wasf1 Pip5kl1 Abi2 Fn1 Pik3ca Rac3 Sos1 Fgfr4 Bdkrb2 Bdkrb1 Fgf16 Fgf17 Cd14 Fgf14 Mos Fgf12 Fgf13 Actb Fgf11 Fgf20 Pak6 Mapk6 Fgf21 Mapk4 Fgf22 Fgf7 Map2k1 Mapk3 Mylk Vcl Arhgef7 Ppp1r12a Fgf2 Fgf6 Fgf4 Fgf3 Fgf9 Itga1 Pak4 Gng12 Egf Fgf10 Pdgfra Rac2 Pdgfa Ptk2 Egfr Pik3r5 Crk Actn1 Pik3r4 Dock1 Bcar1 Pak5 Pak1 Csk Pak2 Pip5k1c Fgf8 Fgf18 Pik3c3 Pik3c2a Pip4k2b Pip4k2c Ins2 Nckap1 Arpc5 Rac1 Fgfr3 Fgfr1 Vav1 Fgfr2 Pik3r1 Raf1 Fgf15 Pik3cg Kras Apc Pip5k1b Pip5k1a Map2k2 Nras Rras Gna12 Fgf23 Slc9a1 Ins1 Actg1 Chrm1 Chrm3 Chrm2 Chrm5 Chrm4 Gna13 Arhgef1 Was Fgf1 Iqgap1 Pak3 Pik3cb Pik3cd Myl3 Cdc42 Diaph1 Cfl1 Cfl2 Pik3c2b Pik3c2g F2r Myl1 Limk1 Arhgef6 Rock2 Rock1 Pfn1 Rras2 Pik3r2 Fgf5 Git1 F2 Pip4k2a Enah Pdgfrb Ezr Arhgef4 Myh10 Pdgfb Rdx Msn Ssh3 Ssh2 Ssh1 Vil1 Rhoa Cyfip2 Brk1 Mras EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES%WIKIPATHWAYS_20260211%WP4349%MUS MUSCULUS Eicosanoid metabolism via cytochrome P450 monooxygenases Ppara Cyp4a12a Cyp4f14 Cyp4a12b Cyp4a10 Cyp2c29 Ephx2 Cyp2c38 Cyp2c39 Cyp2c37 Cyp2c23 Cyp2c55 Cyp2j5 Cyp2c54 Cyp2c40 Cyp4f3 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260211%WP386%MUS MUSCULUS Triacylglyceride synthesis Plpp3 Plpp1 Dgat2 Agpat2 Gk Gpam Gnpat Pnpla2 Dgat1 Mogat1 Agpat4 Lpl Mogat2 Plpp2 Gk2 Agpat5 Lipc Agps Gpd1 Lipe Agpat3 Lipf Agpat1 IL 4 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP93%MUS MUSCULUS IL 4 signaling pathway Fes Akt1 Jak3 Mapk1 Jak2 Nfkb1 Elk1 Prkcd Pik3r1 Pik3ca Ncf1 Shc1 Rasa1 Ptpn6 Il4 Stam Prkd3 Cbl Sos1 Ptpn11 Rela Fyn Prkcz Hmga1 Pawr Grk3 Mapk14 Il2rg Prkci Lck Il4ra Crebbp Spi1 Mapk3 Grb2 Jak1 Stat6 Tyk2 Bcl2l1 Bad Plcg1 Stat1 Ptk2 Mapk11 Stat5a Rps6kb1 Ep300 Pik3cd Dok2 Il13ra1 Socs5 Atf2 Pik3r2 Src Socs1 Cxcr4 Inpp5d Socs3 Irs1 Irs2 Ets1 P53 SIGNALING%WIKIPATHWAYS_20260211%WP2902%MUS MUSCULUS p53 signaling Atr Igf1 Trp73 Zmat3 Adgrb1 Bbc3 Ccng2 Gadd45b Ddb2 Ccnd1 Serpinb5 Shisa5 Cd82 Ei24 Siah1b Perp Siah1a Thbs1 Pten Rprm Gadd45g Sesn2 Rchy1 Sesn1 Sesn3 Steap3 Rrm2 Pidd1 Gtse1 Cop1 Ccne1 Mdm4 Ccne2 Sfn Ppm1d Pmaip1 Serpine1 Cdkn2a Ccnb2 Ccnb3 Igfbp3 Ccnb1 Apaf1 Ccng1 Tsc2 Chek1 Chek2 Rrm2b Gadd45a Bid Casp8 Bax Casp9 Casp3 Fas Cycs Cyct Ccnd2 Ccnd3 Trp53 Cdk6 Cdk4 Cdk2 Cdk1 Mdm2 Atm Cdkn1a WNT SIGNALING%WIKIPATHWAYS_20260211%WP403%MUS MUSCULUS Wnt signaling Dvl3 Fzd3 Mapk9 Rac1 Csnk1e Prkcd Wnt7a Prkd1 Apc Prkcz Pafah1b1 Fzd1 Frat1 Fzd2 Fosl1 Fzd5 Fzd7 Sfrp4 Jun Fzd9 Prkcq Fbxw2 Ccnd1 Prkcg Prkci Prkch Prkce Fzd10 Myc Wnt1 Wnt10b Gsk3b Ppp2r5c Prkca Ppp2r5e Prkcb Ldlr Wnt11 Wnt5a Wnt6 Wnt7b Wnt5b Wnt10a Wnt2b Wnt16 Ccnd2 Ccnd3 Mapk10 Wnt2 Wnt4 Axin1 Wnt3 Plau Fzd6 Fzd8 Ctnnb1 Wnt3a Rhoa Dvl1 Dvl2 METHYLATION%WIKIPATHWAYS_20260211%WP1247%MUS MUSCULUS Methylation Pnmt Tpmt Inmt Hnmt Mat1a Mat2a Mat2b Nnmt Comt IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP10%MUS MUSCULUS IL 9 signaling pathway Il2rg Stat3 Akt1 Jak3 Mapk1 Stat1 Map2k1 Stat5b Stat5a Mapk3 Grb2 Pik3r1 Jak1 Shc1 Tyk2 Vcp Kat5 Ptpn11 Il9 Il9r Socs3 Irs1 Irs2 Map2k2 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4350%MUS MUSCULUS Omega 3 omega 6 fatty acid synthesis Pla2g6 Acsl1 Acsl3 Acsl4 Acox1 Fads2 Acox3 Pla2g4b Pla2g4a Fads1 Acot1 Elovl2 Acot2 Elovl5 Pla2g5 INSULIN SIGNALING%WIKIPATHWAYS_20260211%WP65%MUS MUSCULUS Insulin signaling Akt1 Mapk9 Flot2 Mapk1 Rps6ka3 Gys1 Mink1 Gys2 Sos2 Elk1 Stxbp3 Prkaa2 Gyg1 Pik3ca Fos Insr Cblb Sos1 Mapk13 Shc2 Map2k4 Jun Mapk14 Prkcq Map3k11 Map3k12 Mapk7 Prkch Map3k13 Mapk6 Stxbp2 Map3k14 Mapk4 Akt2 Map2k1 Pten Sorbs1 Mapk3 Grb2 Hras Mapk8 Shc3 Eif4ebp1 Map2k7 Mtor Cyth3 Stxbp4 Kif5b Flot1 Map4k5 Rab4a Xbp1 Tbc1d4 Ehd1 Gab1 Map4k2 Cblc Ehd2 Snap25 Snap23 Pdpk1 Pfkl Rhoj Rac2 Ptprf Rhoq Cap1 Pfkm Rrad Inpp4a Vamp2 Rps6ka4 Rps6ka6 Prkca Sgk3 Sgk2 Crk Arf6 Igf1r Myo1c Ptpn1 Pik3r4 Stx4 Arhgap33 Prkcb Map2k6 Ppp1cc Map3k10 Map2k5 Mapk12 Map2k3 Rapgef1 Map3k7 Map3k9 Grb10 Eif4e Rps6ka1 Pik3c3 Socs1 Kif3a Socs3 Irs1 Pik3c2a Sh2b2 Arf1 Foxo3 Irs4 Trib3 Rac1 Irs3 Prkcd Pik3r1 Raf1 Shc1 Cbl Ptpn11 Pik3cg Prkcz Enpp1 Slc2a4 Map2k2 Prkci Rps6kb2 Slc2a1 Rps6ka5 Egr1 Foxo1 Rps6ka2 Mapk11 Sgk1 Map3k3 Gsk3b Inppl1 Prkaa1 Grb14 Map3k4 Stxbp1 Tsc2 Tsc1 Rps6kb1 Rheb Pik3cb Map3k2 Pik3cd Lipe Pik3c2g Map3k8 Srf Map3k6 Map3k5 Map3k1 Pik3r2 Mapk10 Map4k4 Map4k3 Ikbkb Map4k1 HYPERTROPHY MODEL%WIKIPATHWAYS_20260211%WP202%MUS MUSCULUS Hypertrophy model Vegfa Zeb1 Mstn Atf3 Jund Eif4e Eif4ebp1 Hbegf Ifng Dusp14 Wdr1 Il18 Ankrd1 Il1a Ifrd1 Ccn1 Nr4a3 Il1r1 Adam10 Myog GLUCURONIDATION%WIKIPATHWAYS_20260211%WP1241%MUS MUSCULUS Glucuronidation Pgm2 Ugt2b34 Ugdh Ugt1a10 Ugp2 Pgm1 Ugt1a1 Hk1 Ugt2a2 Ugt1a2 Ugt2a3 Ugt1a5 Ugt1a8 Ugt2a1 Ugt2b1 Pgm3 Pgm5 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260211%WP441%MUS MUSCULUS Matrix metalloproteinases Mmp12 Mmp7 Mmp1a Mmp9 Mmp23 Mmp24 Mmp25 Mmp27 Mmp28 Bsg Mmp20 Mmp21 Mmp11 Mmp13 Mmp15 Mmp16 Mmp17 Mmp19 Timp2 Mmp8 Timp4 Tcf20 Mmp14 Mmp2 Mmp10 Mmp3 Timp1 Tnf Timp3 REGULATION OF CARDIAC HYPERTROPHY BY MIR 208%WIKIPATHWAYS_20260211%WP1526%MUS MUSCULUS Regulation of cardiac hypertrophy by miR 208 Myh7 Med13 Hopx Gata4 Mstn Gja5 IRON HOMEOSTASIS%WIKIPATHWAYS_20260211%WP1596%MUS MUSCULUS Iron homeostasis Il6ra Hjv Hfe Hamp Slc40a1 Ftl1 Il1a Hamp2 Tf Tfr2 Ireb2 Tnf Fth1 Il6}